Query Results 

MAAVTMSVPGRKAPPRPGPVPEAAQPFLFTPRGPSAGG----GPG-SGTSPQVEWTAR

PF02736 // ENSGT00760000118919_8_Domain_0 (59, 98)

RL
VW--VPSELHGFEAAALRDEGEEEAEVELAESGRRLR

ENSGT00760000118919_8_Linker_0_1 (98, 115)

LPRDQIQRMNPPKFSKA

PF00063 // ENSGT00760000118919_8_Domain_1 (115, 982)

EDMAEL
TCLNEASVLHNLRERYYSGLIYTYSGLFCVVINPYKQLPIYTEAIVEMYRGKKRHEVPPH
VYAVTEGAYRSMLQDR-EDQSILCTGESGAGKTENTKK--V---IQ-------YLAHVAS
SPKGRKEP-------GVP-----------------------------ASVSTVSYGELER
QLLQANPILEAFGNAKTVKNDNSS-RFGK------FIRINFDVAGYIVGANI--ETYLLE
KSRAIRQAKDECSFHI----FYQLLGGAG--EQLKADLLLEPCSHYRFLTNGPSSSPGQE
RE-LFQETLESLRVLGFTHEEIISMLRMVSAVLQFGNITLKRERNTDQATMPDNTAAQKL
CRLLGLGVTDFSRALLTPRIK-VGRDYV----QKAQTKEQADFALEALAKATYERLFRWL
VLRLNRALDRSPRQGASFLGILDIAGFEIFQLNSFEQLCINY-TNEKLQQLFNHTMFVL-
-EQEEYQREGIPWTFLDFGLDLQPCIDLIER-------------PANPPGLLALLDEECW
FPKATDK-SFVEKVAQEQGGHPKFQRPRHLRDQADFSVLHYAGKVDYKANEWLMKNMDPL
NDNVAALLHQSTDRLTAEIWKDEHGGFQQFSFPGFFPPSPPGSAERCSSAISPPGV----
-------------EGIVGLEQVSSLGDG-P-P-GGRPRRGMFRTVGQLYKESLSRLMATL
SNTNPSFVRCIVPNHEKRAGKLEPR---------LVL-----DQLRCNGVLEGIRICRQG
FPNRI-------------------LF--QEFRQRYEILTPNA---IPKGFMDGKQACEKM
IQALELDPNL-YRVGQSKIFFRAGVLAQLEEERDLKVTDIIVSFQAAARG--YLARRAFQ
K-RQQQQSALRVMQRNCAAYLKLRHWQWWR-----------------LFTKV--KPLLQV
TR--QDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAE
A---EETRGRLAARKQ-ELELVVSEL----EAR-------VGEEEECSRQMQSEKKRLQQ
HIQELEAHL------------EAEEGARQKLQLEKVTTEAKMKKFEE-DLLLLE---DQN
SKLSKERKLLEDRLAEFSSQAAE--------EEEKVKSLNKLRLKYEATIADMEDRLRKE
EKGRQELEKLKRRLDGESSE-LQEQMVEQQQRAEE-LRAQLGR--KEEELQAALA-----
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----------AELENVSGALNEAESKTIRLSKELSSTEAQLHDAQ---------------
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--------------------

PF01576 // ENSGT00760000118919_8_Domain_13 (1881, 2504)

-LL----------AEEKAAVLRAVEERERAEAEGREREAR
ALSLTRALEEEQEAREE-----------------------LERQNRALRAELEALLSSKD
DVGKSVHELERACRVA--------EQAAN-DLRAQVTELED----ELTAA-EDAKLRLEV
TV---QALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEE-RKQRTLAVAARK-KL
EGELEELKAQMAS-----------A-GQGKEEAVKQL---RK------------------
-MQA-QMKELWREVEETRTS-REEIF-SQNRESEKRLKGLEAEVLRLQEELAASDRARRQ
AQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQ
VESLTT---------ELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARAR--HKM
TIAALESKLAQAEEQLEQET----------------------------------------
----------RERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKR
QLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLR---------------
------------------------------------RGPLTFTTRTVRQVFRLEEGVASD
EE--AEEAQPGSGPS-PEPEGSPPAHPQ--

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----

PF01576 // ENSGT00760000118919_8_Domain_13 (1685, 2464)

LEAE-------------------------------ATGLREQLEEEAAARERAGRE
----------LQTVQAQLSEWRRRQEEEAGALEAGEEARRRTAREAEALTQ-----RLAE
KTEAVD---RLERGRRR-----------LQQELDDA------------------TVDLE-
---QQRQLVGALEKKQRKFDQLL----------AEEKAAVLRAVEERERVEAEGREREAR
ALSLARALEEEQEAREE-----------------------LERQNRALRAELEALLSNKD
DVGKSVHELERARRVA--------EQSAS-ELRAQVTELED----ELTAA-EDAKLRLEV
TV---QALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEE-RKQRAQAVAARK-KL
EAELEELKAQMAA-----------A-GQGKEEAVKQL---RK------------------
-MQA-QVKELWREVEELRGS-KEETS-AQSREREKCFKGLEAEVLRLQEELAAY-HARRQ
AQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNAELLNDRYRKLLLQ
VESLTT---------ELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARAR--QKM
VIAALESKLAQAEEQLEQES----------------------------------------
----------RERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKR
QLEE--------------------------------------------------------
------------------------------------------------------------
------------------------------

MAAVTVSVPGRKAPPRPGPVPEAAQPFLFAPRGPGVGS----GPGGSGTSPQVEWTA

PF02736 // ENSGT00760000118919_8_Domain_0 (58, 102)

RRL
VW--VPSELHGFEAAALRHEGDEEAEVELAESGRRLRLPRD

ENSGT00760000118919_8_Linker_0_1 (102, 115)

QIQRMNPPKFSKA

PF00063 // ENSGT00760000118919_8_Domain_1 (115, 982)

EDMAEL
TCLNEASVLHNLRERYYSGLIYTYSGLFCVVINPYKQLPIYTEAIVEMYRGKKRHEVPPH
VYAVTEGAYRSMLQDR-EDQSILCTGESGAGKTENTKK--V---IQ-------YLAHVAS
SPKGRKEPGVP--------------------------------------------GELER
QLLQANPVLEAFGNAKTVKNDNSS-RFGK------FIRINFDVAGYIVGANI--ETYLLE
KSRAIRQAKDECSFHI----FYQLLGGAG--EQLKADLLLEPFSHYRFLTNGPSSSPGQE
RE-LFQETLESLRVLGFTHEEITSMLRMVSAVLQFGNIVLKRERNTDQASMPDNTAAQKL
CRLLGLGVTDFSRALLTPRIK-VGRDYV----QKAQTKEQADFALEALAKATYERLFRWL
VLRLNRALDRSPRQGASFLGILDIAGFEIFQLNSFEQLCINY-TNEKLQQLFNHTMFVL-
-EQEEYQREGIPWTFLDFGLDLQPCIDLIER-------------PANPPGLLALLDEECW
FPKATDK-SFVEKVAQEQGGHPKFQRPRHLRDQADFSVLHYAGKVDYKANEWLMKNMDPL
NDNVATLLHQSTDRLTAEIWKDEHGGLQQFSFLGSFPPSPPGS---------SGRHSSAI
SPSGGGCCCASTVEGIVGLEQVSSLGDG-P-P-GGRPRRGMFRTVGQLYKESLSRLMATL
SNTNPSFVRCIIPNHEKRAGKLDPR---------LVL-----DQLRCNGVLEGIRICRQG
FPNRI-------------------LF--QEFRQRYEILTPNA---IPKGFMDGKQACEKM
IQALELDPNL-YRVGQSKIFFRAGVLAQLEEERDLKVTDIIVSFQAAARG--YLARKAFQ
K-RQQQQSALRVMQRNCAAYLKLRHWQWWR-----------------LFIKV--KPLLQV
TR--QDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAE
A---EETRGRLAARKQ-ELELVVSEL----EAR-------VGEEEECSRQLQTEKKRLQQ
HIQELETHL------------EAEEGARQKLQLEKVTTEAKLKKLGE-DLLLLE---DQN
AKLSKERKLLEERLSEFSSQAAE--------EEEKVKSLNKLRLKYEATIADMEDRLRKE
EKSRQELEKLKRRLDVEGSE-LQEQMAE

PF01576 // ENSGT00760000118919_8_Domain_13 (1349, 2557)

QQQRAEE-LRAQLGR--KEEELQAALARAEEE
GGVRAQLLKSLREAQAGLAEAQEDLEAERAARAKAEKQRRDLGEELEALRGELEDTLDST
NAQQELRK-RSKREQEVTELKKALEEETRIHEVAVQELRQRHGQALGELAEQLEQARRS-
--KGTWEKTRLTLEAEVSELRTELSNLQTARQEGEQRRRRLESQLQ--------------
------------------EVQG------RVGDGERARAE---------------------
-AAEKLQRAQAELENVSGALSEAESKAIRLSKELTSMEAQLHDAQELLQEETRAKLALGS
RARALEAE-------------------------------AAGLREQLDEEAAARERAGRE
----------LQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALNQ-----RLAE
KAEVVE---RLERGRRR-----------LQQELDDA------------------TVDLE-
---QQRQLVSALEKKQRKFDQLL----------AEEKAAVLRAVEERERAEAEGREREAR
TLSLTRALEEEQEAREE-----------------------LERQNRALRAELEALLSSKD
DVGKSVHELERARRVA--------EQAAN-DLRTQVTELED----ELTAA-EDAKLRLEV
TV---QALKAQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEE-RKQRALAVAARK-KL
EAELEELKAQTTA-----------A-GQGKEEAVKQL---RK------------------
-MQA-QMKELWREVEETRSS-REEIF-AQNRESEKRLKGLEAEVLRLQEELAASDRARRQ
AQQERDEMADEVANGSLSKAAILDEKRQLEGRLGQMEEELEEEQSNAELLNDRYRKLLLQ
VESLTT---------ELSAERSFSAKAESGRQQLERQVQELRERLGEEDAGARAR--QKM
IIAALESKLAQAEEQLEQES----------------------------------------
----------RERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKR
QLEEAEEEASRAQAVRRRLQHELEDVTEASESMNRELNTLRNRLR---------------
------------------------------------RGPLTFTTRTVRQVFRLEEGVASD
EEVAAEEAEPGSGPPPPEPEGSAAAPPQ--

MAAATMTVPGRKVPPRPGPVPEAAQPFLFTPRGPGLGG----GPGGPGTSPQVEWTARRL
VW--VPSELHGFEAAALREEGQEEAEVXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXX

PF00063 // ENSGT00760000118919_8_Domain_1 (137, 982)

XXXXXXTYSGLFCVVINPYKQLPIYTEAIVEMYRGK-RHEVPPH
VYAVTEGAYRSMLQXXXXXXXXXXXXXXXXXXXXXXXX--X-------------------
------------------------------------XXXXXXXXXXXXXXXXXXXGELER
QLLQANPILEAFGNAKTVKNDNSS-RFGK------FIRINFDVAGYIVGANI--ETYLLE
KSRAIRQAKDECSFHI----FYQLLEGAG--EQLKGELLVEPYSNYRFLTNGPSCMPGQE
RE-LFHETLDSLRILGFLYDEIIXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXX-XXXXXX----XXXXXXXXADFALEALAKATYERLFRWL
VLRLNRALDRSPRQGASFLGILDIAGFEIFQLNSFEQLCINY-TNEKLQQLFNHTMFVL-
-EQEEYQREGIPWTFLDFGLDLQPCIDLIER-------------PANPPGLLALLDEECW
FPKATDK-SFVEKVAQEQGGHPKFQRPRQLRDQADFSVLHYAGKXXXXXXXXXMKNMDPL
NDSVAALLHQSTDRLTAEIWKDDLGGFQPFSLLGSLPPPEATGRRGPA------------
-------LSPVGVEGIVGLEQVSSLGDG-P-P-GGRPRRGMFRTVGQLYKESLSRLMATL
SNTNPSFVRCIVPNHEKRAGKLEPR---------LVL-----DQLRCNGVLEGIRICRQG
FPNRI-------------------LF--QEFRQRXXXXXXXX---XXXXXXXXXXXXXXX
IQALYLVPNL-YRVGQSKIFF

ENSGT00760000118919_8_Linker_1_12 (982, 998)

RAGVLAQLEEERDLKV

PF00612 // ENSGT00760000118919_8_Domain_12 (998, 1020)

TDIIVSFQAAARG--YLARRAFQ
K-RQQQQSALRVMQRNCAAYLKLRHWQWWR-----------------LFTKX--XXXXXX
XX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVEEERSRLAEQLRAEAELCAE
A---EETRGRLAARKQ-ELEMVVSEL----EAR-------VGEEEECSRQLQGEKKRLQQ
HIQXXXXXXX---------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX---XXX
XXX----XXXXXXXXXXXXXXXX--------XXXXXXXXXXXXXXXXXXXXXXXXRLRKE
EKNRQELEKLRRRLDGESSE-LQEQVA

PF01576 // ENSGT00760000118919_8_Domain_13 (1348, 2557)

EQQRLLQE-LRAQMGR--KEEELQASLVRVEEE
GGARAQLLKAIREAQAGLAETQEDLEAERLARAKAEKQRRDLGEELEALKSELEDTLDST
NAQQEMR---SKREQEVMELKKALEEEARGREAAVQELRQRHGQALGELMEQLEQARRG-
--KATWDKARSALEAEVSELRAELGTLQTARQDGEQRRRRLESQLT--------------
------------------EVQG------RAGDVERARVE---------------------
-AAEKLQRVQVELESVNGALSEAESRAIRLSKELSSAEAQLRDSQEMLDEESRLKHAAEA
RARALGAE-------------------------------ATGLREQLEEEAAACERAERE
----------L-TAQALLSEWRRRQEEEASAVEAGEEARRRAAREAETLAQ-----RLAE
KTEAAE---RLERGRRR-----------LQQELDDA------------------TMDLE-
---QQRQLVSSLEKKQRKFDQLL----------AEEKAAVLRAVEERERVEAEGREREAR
ALSLARALEEEQEAREE-----------------------LERQNRTLRAEMEALLSSKD
DVSKSVHELERARRVA--------EQVAS-DLRTQVTELED----ELTAA-EDAKLRLEV
TI---QALKAQHERDLQARDEAGEERRRQLAKQLRDAEVERDEE-RKQRALAVAARK-KV
ETELEELKAQMDT-----------A-GQGKEEAVKQL---RK------------------
-MQA-L-KELSREVK-ERSS-REEIF-ALNKESEKGVKGLEAELVRMQEELAAADRARRQ
ALQERDEMADEVASGSLSKAAILEEKRQLEGRLGQMEEELEEEQSNAELLGDRYRKLLLQ
VESLTS---------ELSAERSFSAKAESGRQQLERQIQELRERLGEEDAGARAR--QKM
TIASLESKLAQAEEQLEQET----------------------------------------
----------RERILSGKLVRRAEKRLKEVVLQVEEERRAADQLRDQLEKGNLRMKQLKR
QVEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVVTLRNRLR---------------
------------------------------------RGPLTFTTRTVREVFHLEEGVASD
EEA------DGADPAPQEPEGSPAAQPQ--

MAAVTMSVPGRKATPRPGPVPEAAQPFLFTPRGPSAGG----GPG-LGTSPQVEWTAR

PF02736 // ENSGT00760000118919_8_Domain_0 (59, 98)

RL
VW--VPSELHGFEAAALRDEGEEEAEVELAESGRRLR

ENSGT00760000118919_8_Linker_0_1 (98, 115)

LPRDQIQRMNPPKFSKA

PF00063 // ENSGT00760000118919_8_Domain_1 (115, 982)

EDMAEL
TCLNEASVLHNLRERYYSGLIYTYSGLFCVVINPYKQLPIYTEAIVEMYRGKKRHEVPPH
VYAVTEGAYRSMLQDR-EDQSILCTGESGAGKTENTKK--V---IQ-------YLAHVAS
SPKGRKEP-------GVP-------------------------------------GELER
QLLQANPILEAFGNAKTVKNDNSS-RFGK------FIRINFDVAGYIVGANI--ETYLLE
KSRAIRQAKDECSFHI----FYQLLGGAG--EQLKADLLLEPCSHYRFLTNGPSSSPGQE
RE-LFQETLESLRVLGFTHEEIISMLRMVSAVLQFSNIVLKRERNTDQATMPDNTAAQKL
CRLLGLGVTDFSRALLTPRIK-VGRDYV----QKAQTKEQADFALEALAKATYERLFRWL
VLRLNRALDRSPRQGASFLGILDIAGFEIFQLNSFEQLCINY-TNEKLQQLFNHTMFVL-
-EQEEYQREGIPWTFLDFGLDLQPCIDLIER-------------PANPPGLLALLDEECW
FPKATDK-SFVEKVAQEQGGHPKFQRPRHLRDQADFSVLHYAGKVDYKANEWLMKNMDPL
NDNVAALLHQSTDRLTAEIWKDEHGGFQQFSFLGSFPPSPPGSAGKCSSAVSPPGGG---
-CLCA----STVRLGIVGLEQVSSLGDG-P-P-GGRPRRGMFRTVGQLYKESLSRLMATL
SNTNPSFVRCIVPNHEKRAGKLEPR---------LVL-----DQLRCNGVLEGIRICRQG
FPNRI-------------------LF--QEFRQRYEILTPNA---IPKGFMDGKQACEKM
IQALELDPNL-YRVGQSKIFFRAGVLAQLEEERDLKVTDIIVSFQAAARG--YLARRAFQ
K-RQQQQSALRVMQRNCAAYLKLRHWQWWR-----------------LFTKV--KPLLQV

PF01576 // ENSGT00760000118919_8_Domain_13 (1081, 2505)

TR--QDEVLQARAQELQKVQELQQQSLREVGELRCRMAELEEERTRLAEQLRAEAELCAE
A---EETRGRLAARKQ-ELELVVSEL----EAR-------VGEEEECSRQLQTEKRRLQQ
HIQELEAHL------------EAEEGARQKLQLEKVTTEAKMKKFEE-DLLLLE---DQN
SKLSKERKLLEDRLAEFSSQAAE--------EEEKVKSLNKLRLKYEATIADMEDRLRKE
EKSRQELEKLKRRLDGESSE-LQEQMVEQQQRAED-LRSQLGR--KEEELQAALARAEDE
GGARAQLLKSLREVQAALAEAQEDLEAERVARTKAEKQRRDLGEELEALRGELEDTLDST
NAQQELR---SKREQEVTELKKALEEETRIHEAAVQELRQRHGQALGELAEQLEQARRG-
--KGAWEKTRLALEAEVSELRVELSSLQTARQEGEQRRRRLESQLQ--------------
------------------EVQG------RAGDGERARAE---------------------
-TAEKLQRAQAELENVSGALNEAESKAIRLSKELSSMDAQLHDAQELLQEETRAKLALGS
RVRAMEAE-------------------------------AAGLREQLEEEAAARERAGRE
----------LQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQ-----RLAE
KTETVD---RLERGRRR-----------LQQELDDA------------------TVDLE-
---QQRQLVSTLEKKQRKFDQLL----------AEEKAAVLRAVEERERAEAEGREREAR
ALSLTRALEEEQEAREE-----------------------LERQNRALRAELEALLSSKD
DVGKSVHELERACRVA--------EQAAN-DLRAQVTELED----ELTAA-EDAKLRLEV
TV---QALKTQHERDLQGRDEAGEERRRQLAKQLRDAELERDEE-RKQRALAVAARK-KL
EGELEELKAQLVS-----------A-GQGKEEAVKQL---RK------------------
-MQA-QMKELWREVEESRSS-REEIF-AQNRESDKRLKGLEAEVLRLQEELAASDRARRQ
AQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQ
VESLTS---------ELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARAR--QKM
TIAALESKLAQAEEQLEQES----------------------------------------
----------RERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKR
QLEEAEEEASRAQAGRRRLQRELEDVTESA--------------E---------------
------------------------------------RGPLTFTTRTVRQVFRLEEGVASD
EE--AEEAEPGSGPS-PEPEGSPSAHPQ--

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--------------HS

PF00063 // ENSGT00760000118919_8_Domain_8 (857, 982)

PQA--------GKL-EPRLVL-----DQLRCNGVLEGIRICRQG
FPNRI-------------------HF--QEFRQRFQWLDPGRGSGRDKGSEDDADATLKQ
IQALELDPNL-YRVGQSKIFF

ENSGT00760000118919_8_Linker_8_12 (982, 999)

RAGVLAQLEEERDLKVT

PF00612 // ENSGT00760000118919_8_Domain_12 (999, 1020)

DIIVSFQAAARG--YLARRAFQ
K-RQQQQSALRVMQRNCAAYLKLRHWQWWR-----------------LFTKV--KPLLQV
TR--QDEVLQARAQELQKVQELQQQSAREVGELRGRLTQLEEERSRLAEQLRAESELCAE
A---EETRGRLAARKQ-ELELVVSEL----EAR-------VGEEEECSRQLQSEKRRLQQ
HIQELETHL------------EAEEGARQKLQLEKVTTEAKLKKFEE-DLLLLE---DQN
ARLSKERKLLEERLAEFHSQAAE--------EEEKAKSLHKLRLKYEATIADMEGLQGAC
GRS--SGAS---------------------------LRPTGGPRRPRAHPSLS

PF01576 // ENSGT00760000118919_8_Domain_13 (1374, 2361)

APRVEDE
GGARAQLLKALREAQAGLAEAQEDLEAERAARAKAEKQRRDLGEELEALRGELEDTLDST
NAQQELRNKRSKREQEVTELKKALEEETRAHEAAVQELRQRHGQSLGELAEQLEQARRG-
--RGAWEKARQGLEAEVAELRAELSGLQAVRQEGEQRRRRLEAQLQ--------------
------------------EAQG------RAGDGERARAE---------------------
-AAERLQRVQVELEGAAAALSEAESRAIRLSKELSSAEAQLHDAQELLQEETRAKLALGA
RVRALEAE-------------------------------VAGLQEQLEEEAAARERTGRE
----------LQAAQGQLSEWRRRQEEEAGALEAGEEARRRAAREAEALAQ-----RLAE
RTEAAE---RLERGRRR-----------LQQELDDA------------------TVDLE-
---QQRQRVGTLEKKQRKFDQLL----------ADEKAAVLRAVEERERVEAEGREREAR
TLALTRALEEEQEAREE-----------------------LERQNRALRAELEALLSSKD
DVGKSVHELERAHRVA--------EQAAS-DLRAQVTELED----ELTAA-EDAKLRLEV
TV---QALKTQHERDLQGREESGEERRRQLAKQLRDAEVERDEE-RKQRALALAARK-KL
EAELEELKTQTAA-----------A-GQGKEEAVKQL---RK------------------
-MQSKFLYFF-LET-PSPHSPRSPGL-A--PHTHWDQGGFRAELSPPQQELAAADRARRQ
AQQERDEMADEVASGSLGKAAILEEKRQLEGRLGQMEEELEEEQSNAELLNDRYRKLLLQ
VESLTT---------ELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARAR--QKM
TIAGLESKLAQAEEQLEQESRLIDFAGLFGGVHSCVFDRLRSKSRTATGQDHWTERKVSA
SPDPSLTPLFRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQV------------
------------------------------------------------------------
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------------------------------

MAAVTLSVPGRKVPPRPGPVPEAAQPFLFAPCSPGSG---------AGSPPQVEWTAR

PF02736 // ENSGT00760000118919_8_Domain_0 (59, 98)

RL
VW--VPSELHGFEAAALRDEGDEEAEVELAESGRRLR

ENSGT00760000118919_8_Linker_0_1 (98, 115)

LPRDQIQRMNPPKFSKA

PF00063 // ENSGT00760000118919_8_Domain_1 (115, 572)

EDMAEL
TCLNEASVLHNLRERYYSGLIYTYSGLFCVVINPYKQLPIYTEAIVEMYRGKKRHEVPPH
VYAVTEGAYRSMLQG-------ECGGESGAGKTENTKK--V---IQ-------YLAHVAS
SPKGRKEPGVP--------------------------------------------GELER
QLLQANPVLEAFGNAKTVKNDNSS-RFGK------FIRINFDVAGYIVGANI--ETYLLE
KSRAIRQAKDECSFHI----FYQLLGGAG--EQLKADLLLEPFSHYRFLTSGPPSTASQE
RE-PFQETLESLRVLGFTPEEITSMLRMVSAVLQFGNVILKSERNTDQATMPDNTAAQKL
CRLLGLGVTDFSRALLTPRIK-VGRDYV----QKAQTKEQADFALEALAKATYERLFRWL
VLRLNRALDRSPRQGASFLGILDIAGFEIFQVCAGTAXXXXXXXX-----------XXXX
AGDGGY----------------EPGAG----------DLKLTLRQANPPGLLALLDEECW
FPKATDK-SFVEKVAQEQGGHPKFQRPRQLRDQADFSVLHYAGKVDYKANEWLMKNMDPL
NDNVAALLHQSTDRMTAEIWKDEHGDLPQASFLGSFP---------PLSPGSTGKCCSPS
SPPGGGCLLV-DVESIVGLEQVSSLGDG-P-P-GGRPRRGMFRTVGQLYKESLSRLMATL
SNTNPSFIRCIIPNHEKRAGKLEPR---------LVL-----EQLRCNGVLEGIRICRQG
FPNRI-------------------LF--QEFRQREALRGPGD---K-------------M
V---------------------------------------------------HAAKRCFP
RRRQQQQSALRVMQRNCAAYLKLRHWQWWR-----------------LFIKV--QRRGGR
----AGSVLG-----------------EYGE

PF01576 // ENSGT00760000118919_8_Domain_13 (1112, 1865)

DLLSRRPQLEEERTRLAEQLRAEAELCAE
A---EETRGRLATRKQ-ELELVVTEL----EAR-------MGEEEECSRQLQAEKRRLQL
HIQELETHL------------EAEEGARQKLQLEKVTTEARLKKFEE-DLLLLE---DQN
AKLGKERRLLEERLAEFSSAAAE--------EEEKIKSLNKLRLKYEATIADMEARLRKE
EKGRQELEKLKRRLDGESSE-LQEQDSR------E-FKASLGL--HS------ETLAEEE
GGARTQLLKSLREAQAGLAEAQEDLEAERAARAKAEKHRRDLGEELEALRGELEDTLDST
NAQQELR---TKREQEVTELKKTLEEETRIHEVAVQELRQRHGQALGELAEQLEQARRG-
--KGAWEKTRLALEAEVSELRAELSSLQSARQEGEQRRRRLESQLQ--------------
------------------EVQG------RAGDGERARVE---------------------
-AAEKLQRAQVSGVSVTARPAPRTP------------APRAPQPSELLQEETRAKLALGS
RVRALEAE-------------------------------ASGLREQIEEEAAARERAGRE
----------LQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALAQ-----RLAE
KTE-------------------------------------------------------A-
---Q

PF01576 // ENSGT00760000118919_8_Domain_14 (1112, 1865)

DLLSRRPQLEEERTRLAEQLRAEAELCAEA---EETRGRLATRKQ-ELELVVTEL----EAR-------MGEEEECSRQLQAEKRRLQLHIQELETHL------------EAEEGARQKLQLEKVTTEARLKKFEE-DLLLLE---DQNAKLGKERRLLEERLAEFSSAAAE--------EEEKIKSLNKLRLKYEATIADMEARLRKEEKGRQELEKLKRRLDGESSE-LQEQDSR------E-FKASLGL--HS------ETLAEEEGGARTQLLKSLREAQAGLAEAQEDLEAERAARAKAEKHRRDLGEELEALRGELEDTLDSTNAQQELR---TKREQEVTELKKTLEEETRIHEVAVQELRQRHGQALGELAEQLEQARRG---KGAWEKTRLALEAEVSELRAELSSLQSARQEGEQRRRRLESQLQ--------------------------------EVQG------RAGDGERARVE----------------------AAEKLQRAQVSGVSVTARPAPRTP------------APRAPQPSELLQEETRAKLALGSRVRALEAE-------------------------------ASGLREQIEEEAAARERAGRE----------LQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALAQ-----RLAEKTE-------------------------------------------------------A----QQRQLVSSLEKKQRKFDQLL----------AEEKAAVLRAAEERERVEAEGREREAR
ALSLTRALEEEQEAREE-----------------------LERQNRALRAEMEALLSSKD
DVGKSVHELERARRVA--------EQAAN-DLRAQVTELED----ELTAA-EDAKLRLEV
TV---QALKAQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEE-RKQRALALAARK-KL
EAELEELKAQMAA-----------A-GQGKEEAVKQL---RK------------------
-MQ---MKELWREVEESRTS-REEIF-VQNRESEKRLKGLEADVLRLQEELAASDRARRQ
AQQDRDEMADELANGSLSKAALLEEKRQLEGRLGQLEEELEEEQSNAELLNDRYRKLLLQ
VETLTT---------ELSAERSFSAKAESGRQQLERQIQELRGHLGEEDAGARAR--QKM
MIATLESKLAQAEEQLEQET----------------------------------------
----------RERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQVSGSQLYGTPELA
GVGKDR-------KGHPR---------------------------------VDASHQMGP
QGAPGHHPEPACPR----------------------------------------------
------------------------------

----------------------------------------------------------

PF02736 // ENSGT00760000118919_8_Domain_0 (59, 98)

RL
VW--VPSELHGFEAAALRDEGEEEAEVELAESGRRLR

ENSGT00760000118919_8_Linker_0_1 (98, 115)

LPRDQVQRMNPPKFSKA

PF00063 // ENSGT00760000118919_8_Domain_1 (115, 982)

EDMAEL
TCLNEASVLHNLRERYYSGLIYTYSGLFCVVINPYKQLPIYTEAIVEMYRGKKRHEVPPH
VYAVTEGAYRSMLQDR-EDQSILCTGESGAGKTENTKK--V---IQ-------YLAHVAS
SPKGRKEP-------GVP-----------------------------ASASTMSYGELER
QLLQANPVLEAFGNAKTVKNDNSS-RFGK------FIRINFDVTGYIVGANI--ETYLLE
KSRAIRQAKDECSFHI----FYQLLGGAG--EQLRADLLLEPSSHYRFLTNGPASTPSQE
RE-LFQETLESLRVLGFAPEEITSMLRMVSAVLQFGNVVLKSERNTDQATMPDNTAAQKL
CRLLGLGVTDFSRALLTPRIK-VGRDYV----QKAQTKEQADFALEALAKATYERLFRWL
VLRLNRALDRSPRQGASFLGILDIAGFEIFQLNSFEQLCINY-TNEKLQQLFNHTMFVL-
-EQEEYQREGIPWTFLDFGLDLQPCIDLIER-------------PANPPGLLALLDEECW
FPKATDK-SFVEKVAQEQGGHPKFQRPRHLRDQADFSVLHYAGKVDYKANEWLMKNMDPL
NDNVAALLHQSTD------------------------------------------RL---
-TAEI----WKDVEGIVGLEQVSSLGEG-P-P-GGRPRRGMFRTVGQLYKESLSRLMATL
SNTNPSFVRCIVPNHEKRAGKLEPR---------LVL-----DQLRCNGVLEGIRICRQG
FPNRI-------------------LF--QEFRQRYEILTPNA---IPKGFMDGKQACEKM
IQALELDPNL-YRVGQSKIFFRAGVLAQLEEERDLKVTDIIVSFQAAARG--YLARRAFQ
R-RQQQQSALRVMQRNCAAYLKLRHWQWWR-----------------LFIKV--KPLLQV

PF01576 // ENSGT00760000118919_8_Domain_13 (1081, 2504)

TR--QDEVLQARAQELQKVQELQQQSARQVGELQDRVAQLEEERARLAEQLRAEAELCAE
A---EETRGRLATRKQ-ELELVVTEL----EAR-------MGEEEECSRQLQAEKKRLQL
HIQELETHL------------EAEEGARQKLQLEKVTTEAKLKKFEE-DLLLLE---DQN
AKLGKERRLLEERLAEFSSQAAE--------EEEKIKSLNKLRLKYEATIADMEDRLRKE
EKGRQELEKLKRRLDGESSE-LQEQMAEQQQRAEE-LRAQLGR--KEEELQAALVRAEEE
GGARAQLLKSLREAQAGLAEAQEDLEAERVARAKAEKQRRDLGEELEALRGELEDTLDST
NAQQELR---TKREQEVTELKKALEEETRLHEVAVQELRQRHGQALGELMEQLEQARRG-
--KGAWEKMRLALEAEVSELRTELSSLQTSRQEGEQKRRRLESQLQ--------------
------------------EVQG------RAGDGERARVE---------------------
-AAEKLQRAQAELETVSGALSEAESRAIRLGKELSSTEGQLHDAQELLQEETRAKLALGS
RVRALEAE-------------------------------AAGLREQMEEEAAARERAGRE
----------LQAAQVQLSEWRRRQEEEAGALEAGEEARRRAAREAEALAQ-----RLAE
KTEAVE---RLERGRRR-----------LQQELDDV------------------TVDLE-
---QQRQLVSTLDKKQRKFDQLL----------AEEKAAVLRAVEERERVEAEGREREAR
ALSLTRALEEEQEAREE-----------------------LERQNRALRAELEALLSSKD
DVGKSVHELERARRVA--------DQAAN-DLRAQVTELED----ELTAA-EDAKLRLEV
TV---QALKAQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEE-RKQRALAVAARK-KL
EAELEELKAQTAA-----------A-GQGREEAVKQL---RK------------------
-MQV-QMKELWREVEESRTS-REEIF-VQNRESEKRLKGLEAEVLRLQEELAASDRARRQ
AQQDRDEMADEMANGSLSKAALLEEKRQLEGRLGQLEEELEEEQSNAELLNDRYRKLVLQ
VETLTT---------ELSAERSFSAKAESGRQQLERQIQELRGHLGEEDAGARAR--QKM
TIATLESKLAQAEEQLEQES----------------------------------------
----------RERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKANLRVKQLKR
QLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRL----------------
------------------------------------------------------------
------------------------------

MAAVTMSVSGRKVASRPGPVPEAAQSFLYAPRTPNVGG----PG-----GPQVEWTAR

PF02736 // ENSGT00760000118919_8_Domain_0 (59, 98)

RM
VW--VPSELHGFEAAALRDEGEEEAEVELAESGRRLR

ENSGT00760000118919_8_Linker_0_1 (98, 115)

LPRDQIQRMNPPKFSKA

PF00063 // ENSGT00760000118919_8_Domain_1 (115, 982)

EDMAEL
TCLNEASVLHNLRERYYSGLIYTYSGLFCVVINPYKQLPIYTEAIVEMYRGKKRHEVPPH
VYAVTEGAYRSMLQDR-EDQSILCTGESGAGKTENTKK--V---IQ-------YLAHVAS
SPKGRKEPGVPASVST------------------------------------MSYGELER
QLLQANPILEAFGNAKTVKNDNSS-RFGK------FIRINFDIAGYIVGANI--ETYLLE
KSRAIRQAKDECSFHI----FYQLLGGAG--EQLKADLLLEPCSHYRFLTNGPSSSPGQE
RE-LFQETLESLRVLGLLPEEITAMLRTVSAVLQFGNIVLKKERNTDQATMPDNTAAQKL
CRLLGLGVTDFSRALLTPRIK-VGRDYV----QKAQTKEQADFALEALAKATYERLFRWL
VLRLNRALDRSPRQGASFLGILDIAGFEIFQLNSFEQLCINY-TNEKLQQLFNHTMFVL-
-EQEEYQREGIPWTFLDFGLDLQPCIDLIER-------------PANPPGLLALLDEECW
FPKATDK-SFVEKVAQEQGSHPKFQRPRNLRDQADFSVLHYAGKVDYKASEWLMKNMDPL
NDNVAALLHQSTDRLTAEIWKD--------------------------------------
------------VEGIVGLEQVSSLGDG-P-P-GGRPRRGMFRTVGQLYKESLSRLMATL
SNTNPSFVRCIVPNHEKRAGKLEPR---------LVL-----DQLRCNGVLEGIRICRQG
FPNRI-------------------LF--QEFRQRYEILTPNA---IPKGFMDGKQACEKM
IQALELDPNL-YRVGQSKIFFRAGVLAQLEEERDLKVTDIIVSFQAAARG--YLARRAFQ
R-RQQQQSALRVMQRNCAAYLKLRNWQWWR-----------------LFIKV--KPLLQV

PF01576 // ENSGT00760000118919_8_Domain_13 (1081, 2504)

TR--QDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERTRLAEQLRAEAELCSE
A---EETRARLAARKQ-ELELVVTEL----EAR-------VGEEEECSRQLQSEKKRLQQ
HIQELESHL------------EAEEGARQKLQLEKVTTEAKMKKFEE-DLLLLE---DQN
SKLSKERRLLEERLAEFSSQAAE--------EEEKVKSLNKLRLKYEATISDMEDRLKKE
EKGRQELEKLKRRLDGESSE-LQEQMVEQKQRAEE-LLAQLGR--KEDELQAALLRAEEE
GGARAQLLKSLREAQAGLAEAQEDLEAERVARAKAEKQRRDLGEELEALRGELEDTLDST
NAQQELR---SKREQEVTELKKALEEESRAHEVSMQELRQRHSQALVEMAEQLEQARR--
-GKGVWEKTRLSLEAEVSELKAELSSLQTSRQEGEQKRRRLESQLQ--------------
------------------EVQG------RSSDSERARSE---------------------
-AAEKLQRAQAELESVSTALSEAESKAIRLGKELSSAESQLHDTQELLQEETRAKLALGS
RVRALEAE-------------------------------AAGLREQMEEEVVARERAGRE
----------LQSTQAQLSEWRRRQEEEAAVLEAGEEARRRAAREAETLTQ-----RLAE
KTEAVE---RLERARRR-----------LQQELDDA------------------TVDLG-
---QQKQLLSTLEKKQRKFDQLL----------AEEKAAVLRAVEDRERIEAEGREREAR
ALSLTRALEEEQEAREE-----------------------LERQNRALRAELEALLSSKD
DVGKNVHELERARKAA--------EQAAS-DLRTQVTELED----ELTAA-EDAKLRLEV
TV---QALKAQHERDLQGRDDAGEERRRQLAKQLRDAEVERDEE-RKQRALAMAARK-KL
ELELEELKAQTSA-----------A-GQGKEEAVKQL---KK------------------
-MQV-QMKELWREVEETRSS-RDEMF-TLSRENEKKLKGLEAEVLRLQEELAASDRARRQ
AQQDRDEMAEEVASGNLSKAATLEEKRQLEGRLSQLEEELEEEQNNSELLKDHYRKLVLQ
VESLTT---------ELSAERSFSAKAESGRQQLERQIQELRARLGEEDAGARAR--QKM
LIAALESKLAQAEEQLEQES----------------------------------------
----------RERILSGKLVRRAEKRLKEVVLQVDEERRVADQVRDQLEKSNLRLKQLKR
QLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLR---------------
------------------------------------RGPLTFTTRTVRQVFRLEEGVASD
EEE-AEGAEPGSAPG-QEPEAPPPATPQ--

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------

PF00063 // ENSGT00760000118919_8_Domain_7 (704, 860)

QVDYKASEWLMKNMDPL
NDNVSALLHHSSDRLTAEIWR---------------------------------------
-----------DVESIVGLEQVSSLGEGSGVGPGGRPRRGMFRTVGQLYKESLSRLMSTL
NNTNPSFVRCIVPNHEKRVSDPRPHLPPAALGPTSPVAEAPQHPLEACG-----LPCAPP
PPSRAPPLCVTCPIAVDSIWALWLVFLDVTFAPGFPGFVPSASSAGSWSLT----GC---
---LDQGPGRGVEGGEGKMAL--------ERPPGLRVE--VDGREKAGDGA-------SG
D------------------VGGDQDGGFWRR----------GGVLRSMWRGAS---GVRV
R---------SR----------GFGLGPALIPISSLLRVLEKEKLSLVEQLRSEAALCAE
A---EELRVRLSNRKQ-ELEALVAGL----ETR-------MSEEEERSGQLLNEKRRLQQ
HVQVCPSSPNLTASPPPC---SSSRNSSHHL-----------SLLSPVSLFLLPL----Q
------------TLLSISSPSKTQGSPSSSNTGPSIDCIYRALRVYGEHCTEHLGEYR--
--TIQGYEKIDRPLDRRMGHPYLSNVGLEE

PF01576 // ENSGT00760000118919_8_Domain_14 (1351, 1665)

GSRKDKLQAQLGC--KEEELQAAVAEAEEE
GGARAGLLKSLREAQAGLAEAQEDLDVERAARAKAEQQRRDLGEELEALRGELEDTLDST
NAQQELR---SKRELELSELKKALEEEARNHEAVVQELRQRQTQALAELGEQLDQARRG-
--KAAWEKMRVTLEVEVSDLQSELKGLQAARQEGEQRRRRLEGQLA--------------
------------------ELQA------RAGDGERSRAE---------------------
-ATEKLQRAQAELESVSGALGEAESKAIKLSKELSGVEAQLRDTQVPPASVPRSGAS---
LVTIWVSPHPLVLSPFLPLSHRPPASPTSPAPPFPPSSSLTDRPRLPPPRSCCRRRPGPS
------------------SRWARGAWAGKRGRDLARL-----------------CPHLCL
HLS-------------------------LPSHLSAS-----------------LPPTLR-
----PRLPPSHLHPSLPPF-------DIPPKLLAEEKAAVQRAVKERYRAEAEGREREAR
ALALARALEEEKEQRED-----------------------LERQNRTLRAELEELVSSKD
DVGKSVHELERARRAA--------EQQAA-ELRAQLAELED----ELLLA-EDGKLRLEV
TA---QALKAQHERELQGRDEAGEERRKLLAKQLRETELERDEE-RKQRAAAVAARK-KA
ETELEELKAQTEGA------------IKGREEAGKQLK---K------------------
--LQLHMKELCLEVEESRTS-REEIF-TQSRDSEKRLKGLEAELLRLQE-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------

------------------------------------------------------------
---------HGFEAAALRDEGEEEAEVELAESGRRLRLPRDQVQRMNPPKFSKA

PF00063 // ENSGT00760000118919_8_Domain_1 (115, 982)

EDMAEL
TCLNEASVLHNLRERYYSGLIYTYSGLFCVVINPYKQLPIYTEAIVEMYRGKKRHEVPPH
VYAVTEGAYRSMLQDR-EDQSILCTGESGAGKTENTKK--V---IQ-------YLAHVAS
SPKGRKEPGVPV------------------------------------STRLSHPGPLER
QLLQANPVLEAFGNAKTVKNDNSS-RFGK------FIRINFDVAGYIVGANI--ETYLLE
KSRAIRQAKDECSFHI----FYQLLGGAG--EQLRADLLLEPSSHYRFLTNGPASTPSQE
RE-LFQETLESLRVLGFTPEEITSMLRMVSAVLQFGNVVLKSERNTDQATMPDNTAAQKL
CRLLGLGVTDFSRALLTPRIK-VGRDYV----QKAQTKEQADFALEALAKATYERLFRWL
VLRLNRALDRSPRQGASFLGILDIAGFEIFQLNSFEQLCINY-TNEKLQQLFNHTMFVL-
-EQEEYQREGIPWTFLDFGLDLQPCIDLIER-------------PANPPGLLALLDEECW
FPKATDK-SFVEKVAQEQGGHPKFQRPRHLRDQADFSVLHYAGKVDYKANEWLMKNMDPL
NDNVAALLHQSTDRLTAEIWKD--------------------------------------
------------VEGIVGLEQVSSLGDG-P-P-GGRPRRGMFRTVGQLYKESLSRLMATL
SNTNPSFVRCIVPNHEKRAGKLEPK---------LVL-----DQLRCNGVLEGIRICRQG
FPNRI-------------------LF--QEFRQRYEILTPNA---IPKGFMDGKQACEKM
IQALELDPNL-YRVGQSKIFFRAGVLAQLEEERDLKVTDIIVSFQAAARG--YLARRAFQ
R-RQQQQSALRVMQRNCAAYLKLRHWQWWR-----------------LFIKV--KPLLQV

PF01576 // ENSGT00760000118919_8_Domain_14 (1081, 1631)

TR--QDEVLQARAQELQKVQELQQQSARQVGELQDRVAQLEEERTRLAEQLRAEAELCAE
A---EETRGRLATRKQ-ELELVVTEL----EAR-------MGEEEECSRQLQAEKKRLQL
HIQELETHL------------EAEEGARQKLQLEKVTTEAKLKKFEE-DLLLLE---DQN
AKLGKERRLLEERLAEFSSQAAE--------EEEKIKSLNKLRLKYEATIADMEDRLRKE
EKGRQELEKLKRRLDGESSE-LQEQMVEQQQRAEE-LRAQLGR--KEEELQAALVRAEEE
GGARAQLLKSLREVQAGLAEAQEDLEAERVARAKAEKQRRDLGEELEALRGELEDTLDST
NAQQELR---TKREQEVTELKKALEEETRLHEVAVQELRQRHGQALGELVEQLEQARRG-
--KGAWEKTRLALEAEVSELRTELSSLQTSRQEGEQKRRRLESQLQ--------------
------------------EVQG------RAGDGERARVE---------------------
-AAEKLQRAQ

ENSGT00760000118919_8_Linker_14_13 (1631, 1664)

VRGVSPPAPAP--TPTPF--------TLTFPIH

PF01576 // ENSGT00760000118919_8_Domain_13 (1664, 1894)

LQELLQEETRAKLALGS
RVRALEAE-------------------------------AAGLREQMEEEAAARERAGRE
----------LQAAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAETLAQ-----RLGE
KTEAVE---RLERGRRR-----------LQQELDDV------------------TVDLE-
---QQRQLVSTLEKKQRKFDQVG----------ASVYPAG--------------R--SAR
PLSSL------------------------------------PLVARA---LL------LT
LVSLQVHELERARRVA--------DQAAN-DLRAQVTELED----ELTAA-EDAKLRLEV
TV---QALKAQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEE-RKQRALAVAARK-KL
EAELEELKAQAAA-----------A-GQGKEEAVKQL---RK------------------
-TQV-QMKELWREVEESRTS-REEIF-VQNRESEKRLKGLEAEVLRLQEELAASDRARRQ
AQQDRDEMADEMANGSLSKAALLEEKRQLEGRLGQLEEELEEEQSNAELLNDRYRKLLLQ
VETLST---------ELSAERSFSAKAESGRQQLERQIQELRGHLGEEDAGARAR--QKM
TIATLESKLAQAEEQLEQES----------------------------------------
----------RERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKANLRVKQLKR
QLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLR---------------
------------------------------------RGPLTFTTRTVRQVFRLEEGVASD
EEE-AEDKEPASA---PEPEGPPPAQPQ--

MAAVTVSVPGRKAPPRPGPVPEAAQPFLFAPRGPGVGS----GPGGSATSPQVEWTAR

PF02736 // ENSGT00760000118919_8_Domain_0 (59, 98)

RL
VW--VPSELHGFEAAALRHEGDEEAEVELAESGRRLR

ENSGT00760000118919_8_Linker_0_1 (98, 115)

LPRDQIQRMNPPKFSKA

PF00063 // ENSGT00760000118919_8_Domain_1 (115, 982)

EDMAEL
TCLNEASVLHNLRERYYSGLIYTYSGLFCVVINPYKQLPIYTEAIVEMYRGKKRHEVPPH
VYAVTEGAYRSMLQDR-EDQSILCTGESGAGKTENTKK--V---IQ-------YLAHVAS
SPKGRKEPGVP--------------------------------------------GELER
QLLQANPVLEAFGNAKTVKNDNSS-RFGK------FIRINFDVAGYIVGANI--ETYLLE
KSRAIRQAKDECSFHI----FYQLLGGAG--EQLKADLLLEPFSHYRFLTNGPSSSPGQE
RE-LFQETLESLRVLGFTHEEITSMLRMVSAVLQFGNIVLKRERNTDQASMPDNTAAQKL
CRLLGLGVTDFSRALLTPRIK-VGRDYV----QKAQTKEQADFALEALAKATYERLFRWL
VLRLNRALDRSPRQGASFLGILDIAGFEIFQLNSFEQLCINY-TNEKLQQLFNHTMFVL-
-EQEEYQREGIPWTFLDFGLDLQPCIDLIER-------------PANPPGLLALLDEECW
FPKATDK-SFVEKVAQEQGGHPKFQRPRHLRDQADFSVLHYAGKVDYKANEWLMKNMDPL
NDNVATLLHQSTDRLTAEIWKD--------------------------------------
------------VEGIVGLEQVSSLGDG-P-P-GGRPRRGMFRTVGQLYKESLSRLMATL
SNTNPSFVRCIIPNHEKRAGKLDPR---------LVL-----DQLRCNGVLEGIRICRQG
FPNRI-------------------LF--QEFRQRYEILTPNA---IPKGFMDGKQACEKM
IQALELDPNL-YRVGQSKIFFRAGVLAQLEEERDLKVTDIIVSFQAAARG--YLARKAFQ
K-RQQQQSALRVMQRNCAAYLKLRHWQWWR-----------------LFIKV--KPLLQV

PF01576 // ENSGT00760000118919_8_Domain_13 (1081, 2504)

TR--QDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRSEAELCAE
A---EETRGRLAARKQ-ELELVVSEL----EAR-------VGEEEECSRQLQTEKKRLQQ
HIQELETHL------------EAEEGARQKLQLEKVTTEAKLKKLGE-DLLLLE---DQN
AKLSKERKLLEERLSEFSSQAAE--------EEEKVKSLNKLRLKYEATIADMEDRLRKE
EKSRQELEKLKRRLDVEGSE-LQEQMAEQQQRAEE-LRAQLGR--KEEELQAALARAEEE
GGARAQLLKSLREAQAGLAEAQEDLEAERAARAKAEKQRRDLGEELEALRGELEDTLDST
NAQQELR---SKREQEVTELKKALEEETRIHEVAVQELRQRHGQALGELAEQLEQARRS-
--KGTWEKTRLTLEAEVSELRTELSNLQTARQEGEQRRRRLESQLQ--------------
------------------EVQG------RAGDGERARAE---------------------
-AAEKLQRAQAELENVSGALSEAESRAIRLSKELTSMEAQLHDAQELLQEETRAKLALGS
RARALEAE-------------------------------AAGLREQLDEEAAARERAGRE
----------LQAAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEVLNQ-----RLAE
KAEVVE---RLERGRRR-----------LQQELDDA------------------TVDLE-
---QQRQLVSALEKKQRKFDQLL----------AEEKAAVLRAVEERERAEAEGREREAR
TLSLTRALEEEQEAREE-----------------------LERQNRALRAELEALLSSKD
DVGKSVHELERARRVA--------EQAAS-DLRMQVTELED----ELTAA-EDAKLRLEV
TM---QALKAQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEE-RKQRALAMAARK-KL
EAELEELKSQTTA-----------A-GQGKEEAVKQL---RK------------------
-MQA-QMKELWREVEETRSS-REEIF-AQNRESEKRLKGLEAEVLRLQEELAASDRARRQ
AQQERDEMADEVANGSLSKAAILDEKRQLEGRLGQMEEELEEEQSNAELLNDRYRKLLLQ
VESLTT---------ELSAERSFSAKAESGRQQLERQVQELRDRLGEEDAGARAR--QKM
IIAALESKLAQAEEQLEQES----------------------------------------
----------RERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKR
QLEEAEEEASRAQAVRRRLQHELEDVTEASESMNRELNTLRNRLR---------------
------------------------------------RGPLTFTTRTVRQVFRLEEGVASD
EEAVAEEAEPGSGPPPPEPEGSAAAPPQ--

MAAATLSMSGRKAPPRPGPVPEAAQSFLYAPRSPGAGP----GA----GAPQVEWTARRL
VW--VPSELHGFEAAVLRHEGEEEAEVELAESGRRLRLPRDQIQRMNPPKFSKA

PF00063 // ENSGT00760000118919_8_Domain_1 (115, 982)

EDMAEL
TCLNEASVLHNLRERYYSGLIYTYSGLFCVVINPYKQLPIYTEAIVEMYRGKKRHEVPPH
VYAVTEGAYRSMLQDR-EDQSILCTGESGAGKTENTKK--V---IQ-------YLAHVAS
SPKGRKEPG-------VP-------------------------------------GELER
QLLQANPVLEAFGNAKTVKNDNSS-RFGK------FIRINFDVAGYIVGANI--ETYLLE
KSRAIRQAKDECSFHI----FYQLLGGAG--EQLKADLLLEPSSHYRFLTNGLASTPSQE
RE-LFQETLESLRVLGFTPEEITSMLRMVSAVLQFGNVILKSERNTDQATMPDNTAAQKL
CRLLGLGVTDFSRALLTPRIK-VGRDYV----QKAQTKEQADFALEALAKATYERLFRWL
VLRLNRALDRSPRQGASFLGILDIAGFEIFQLNSFEQLCINY-TNEKLQQLFNHTMFVL-
-EQEEYQREGIPWTFLDFGLDLQPCIDLIER-------------PANPPGLLALLDEECW
FPKATDK-SFVEKVAQEQGGHPKFQRPRHLRDQADFSVLHYAGKVDYKANEWLMKNMDPL
NDNVAALLHQSTDRLTAEIWKDGHGELPQASFLGSFP---------ALSPGSPGRCCSAS
HLPGGGRLC-SDVEGIVGLEQVSSLGDG-P-P-GGRPRRGMFRTVGQLYKESLSRLMATL
SNTNPSFVRCIVPNHEKRAGKLEPR---------LVL-----DQLRCNGVLEGIRICRQG
FPNRI-------------------LF--QEFRQRYEILTPNA---IPKGFMDGKQACEKM
IQALELDPNL-YRVGQSKIFFRAGVLAQLEEERDLKVTDIIVSFQAAARG--YLARRAFQ
R-RQQQQSALRVMQRNCAAYLKLRHWQWWR-----------------LFIKV--KPLLQV

PF01576 // ENSGT00760000118919_8_Domain_13 (1081, 2504)

TR--QDEVLQARAQELQKVQELQQQSARQVGELQDRVTQLEEERARLAEQLRAETELCAE
A---EETRGRLATRKQ-ELELVVTEL----EAR-------MSEEEECSRQLQAEKRRLQL
HIQELETHL------------EAEEGARQKLQLEKVTTEAKLKKFEE-DLLLLE---DQN
TKLGKERRLLEERLAEFSSQAAE--------EEEKIKSLNKLRLKYEATIADMEDRLRKE
EKGRQELEKLKRRLDGESSE-LQEQMAEQQQRAEE-LRAQLGR--KEEELQAALVRAEEE
GGARAQLLKSLREAQAGLAEAQEDLEAERAARAKAEKQRRDLSEELEALRGELEDTLDST
NAQQELR---TKREQEVTELKKALEEETRLHEVAVQELRQRQGQALGELVEQLEQARRG-
--KSAWEKTRLALEAEVSELRTELSNLQTSRQEGEQKRRRLESQLQ--------------
------------------EVQG------RAGDGERARVE---------------------
-ATEKLQRAQAELETVSGALSEAESKAIRLGKELSSTEGQLHDTQELLQEETRAKLALGS
RVRALEAE-------------------------------AAGLREQMEEEAAARERAGRE
----------LQAAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALAQ-----RLTE
KTEAVE---RLERGRHR-----------LQQELDDV------------------TVDLE-
---QQRQLVSTLEKKQRKFDQLL----------AEEKAAVLRAVEERERVEAEGREREAR
ALSLTRALEEEQEAREE-----------------------LERQNRALRAELEALLSSKD
DVGKSVHELERTRRVA--------EQAAN-DLRTQVTELED----ELTAA-EDAKLRLEV
TV---QALKAQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEE-RKQRALAVAARK-KL
ETELEELKAQTAA-----------A-GQGKEEAVKQL---RK------------------
-LQV-QMKELWREVEESRTS-REEIF-VQNRESEKRLKSLEAEVLRLQEELAASDRARRQ
AQQDRDEMADEMANGSLSKAALLEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQ
VDTLTT---------ELSTERSFSAKAESGRQQLERQIQELRGHLGEEDAGARAR--QKM
TIATLESKLSQAEEQLEQES----------------------------------------
----------RERILSGKLLRRAEKRLKEVVLQVEEERRVADQLRDQLEKANLRVKQLKR
QLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLGPCR------------
---------------------------------PPQARPLTFTTRTVRQVFRLRRAWFPT
RRA-RRRRNPAPSPRPP--ACSP-A-----

MAAVTLSVPGRKVAARAGPVPEAAQPFLFTPRTPNVGG----P-----GGPQVEWTAR

PF02736 // ENSGT00760000118919_8_Domain_0 (59, 98)

RL
VW--VPSELHGFEAAALRDEGEEEAEVELAESGRRLR

ENSGT00760000118919_8_Linker_0_1 (98, 115)

LPRDQIQRMNPPKFSKA

PF00063 // ENSGT00760000118919_8_Domain_1 (115, 982)

EDMAEL
TCLNEASVLHNLRERYYSGLIYTYSGLFCVVINPYKQLPIYTEAIVEMYRGKKRHEVPPH
VYAVTEGAYRSMLQGESRL---GPGWESGAGKTENTKK--V---IQ-------YLAHVAS
SPKGRKEP-------GVP-------------------------------------GELER
QLLQANPILEAFGNAKTVKNDNSS-RFGK------FIRINFDVAGYIVGANI--ETYLLE
KSRAIRQAKDECSFHI----FYQLLGGAG--EQLKADLLLEPCSHYRFLTNGPSSSPGQE
RE-LFQETLESLRVLGFLPDEITAMLRTVSAVLQFGNIVLKRERNTDQATMPDNTAAQKL
CRLLGLGVTDFSRALLTPRIK-VGRDYV----QKAQTKEQADFALEALAKATYERLFRWL
VLRLNRALDKSPRQGASFLGILDIAGFEIFQLNSFEQLCINY-TNEKLQQLFNHTMFVL-
-EQEEYQREGIPWTFLDFGLDLQPCIDLIER-------------PANPPGLLALLDEECW
FPKATDK-SFVEKVAQEQGSHPKFQRPRHLRDQADFSVLHYAGKVDYKASEWLMKNMDPL
NDNVAALLHQSTDRLTAEIWKDEQGGLQQFTLLGSFPSS---------PPGPAGTLSSGA
PPPGGGFLCAPTVEGIVGLEQVSSLGDG-P-P-GGRPRRGMFRTVGQLYKESLSRLMATL
SNTNPSFVRCIVPNHEKRAGKLEPR---------LVL-----DQLRCNGVLEGIRICRQG
FPNRI-------------------LF--QEFRQRYEILTPNA---IPKGFMDGKQACEKM
IQALELDPNL-YRVGQSKIFFRAGVLAQLEEERDLKVTDIIVSFQAAARG--YLARRAFQ
R-RQQQQSALRVMQRNCAAYLKLRNWQWWR-----------------LFIKV--KPLLQV

PF01576 // ENSGT00760000118919_8_Domain_13 (1081, 2504)

TR--QDEVLQARAQELQKVQELQQQSAREVGELQSRVAQLEEERSRLAEQLRAEAELCSE
A---EETRARLSARKQ-ELELVVSEL----EAR-------VGEEEECSRQLQGEKKRLQQ
HIQELESHL------------EAEEGARQKLQLEKVTTEAKMKKFEE-DLLLLE---DQN
AKLSKERRLLEERLSEFSSQAAE--------EEEKVKSLNKLRLKYEATIADMEDRLKKE
EKGRQELEKLKRRLDGESSE-LQEQMVEQKQRAEE-LLAQLGR--KEDELQAALVRAEEE
GGARAQLLKSLREAQAGLAEAQEDLETERAARAKAEKQRRDLGEELEALRGELEDTLDST
NAQQELR---SKREQEVTELKKTLEEETHAHEVAMQELRQRHGQALGELAEQLEQARRG-
--KGVWEKTRLTLEAEVTELRAELSSLRTSRQEGEQKRRRLESQLQ--------------
------------------EVQG------RASDVDRARTE---------------------
-AAEKLQRAQAELESVSTALSEAESKAIRLGKELSSAESQLHDTQELLQEETRAKLALGS
RVRALEAE-------------------------------AAGLREQMEEEVVARERAGRE
----------LQSAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAETLAQ-----RLAE
KTEAVE---RLERARRR-----------LQQELDDA------------------TVDLG-
---QQKQLLSTLEKKQRKFDQLL----------AEEKAAVLRAVEDRERVEAEGREREAR
ALSLTRALEEEQEAREE-----------------------LERQNRALRAELEALLSSKD
DVGKNVHELERARRVA--------EQAAN-DLRTQVTELED----ELTAT-EDAKLRLEV
TV---QALKAQHERDLQGRDDAGEERRKQLVKQLRDAEVERDEE-RKQRALAVAARK-KL
EAELEELKAQTSA-----------A-GQGKEEAVKQL---RK------------------
-MQV-QMKELWREVEETRSS-REEIF-TLNKESEKRLKGLEAEVLRLQEELAASDRARRQ
AQQDRDEMAEEVATGNLSKTAILEEKRQLEGRLGQLEEELEEEQNNSEILRDHYRKLLLQ
VESLTT---------ELSAERSFSAKAESGRQQLERQIQELKSRLGEEDAGARAR--QKM
LIAALESKLAQAEEQLEQES----------------------------------------
----------RERILSGKLVRRAEKRLKEVVLQVDEERRVADQLRDQLEKGNLRLKQLKR
QLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLR---------------
------------------------------------RGPLTFTTRTVRQVFRLEEGVASD
EE--EAEGAERGPAPPQEPEAPSLATPQ--

MAAVTLSVPGRKVPPRPGPVPEAAQPFLFAPCSPGSG---------AGSPPQVEWTAR

PF02736 // ENSGT00760000118919_8_Domain_0 (59, 98)

RL
VW--VPSELHGFEAAALRDEGDEEAEVELAESGRRLR

ENSGT00760000118919_8_Linker_0_1 (98, 115)

LPRDQIQRMNPPKFSKA

PF00063 // ENSGT00760000118919_8_Domain_1 (115, 982)

EDMAEL
TCLNEASVLHNLRERYYSGLIYTYSGLFCVVINPYKQLPIYTEAIVEMYRGKKRHEVPPH
VYAVTEGAYRSMLQG-------ECGGESGAGKTENTKK--V---IQ-------YLAHVAS
SPKGRKEPGVP--------------------------------------------GELER
QLLQANPVLEAFGNAKTVKNDNSS-RFGK------FIRINFDVAGYIVGANI--ETYLLE
KSRAIRQAKDECSFHI----FYQLLGGAG--EQLKADLLLEPFSHYRFLTSGPPSTASQE
RE-PFQETLESLRVLGFTPEEITSMLRMVSAVLQFGNVILKSERNTDQATMPDNTAAQKL
CRLLGLGVTDFSRALLTPRIK-VGRDYV----QKAQTKEQADFALEALAKATYERLFRWL
VLRLNRALDRSPRQGASFLGILDIAGFEIFQLNSFEQLCINY-TNEKLQQLFNHTMFVL-
-EQEEYQREGIPWTFLDFGLDLQPCIDLIER-------------PANPPGLLALLDEECW
FPKATDK-SFVEKVAQEQGGHPKFQRPRQLRDQADFSVLHYAGKVDYKANEWLMKNMDPL
NDNVAALLHQSTDRMTAEIWKDEHGDLPQASFLGSFP---------PLSPGSTGKCCSPS
SPPGGGCLLV-DVESIVGLEQVSSLGDG-P-P-GGRPRRGMFRTVGQLYKESLSRLMATL
SNTNPSFIRCIIPNHEKRAGKLEPR---------LVL-----EQLRCNGVLEGIRICRQG
FPNRI-------------------LF--QEFRQRYEILTPNA---IPKGFMDGKQACEKM
IQALELDPNL-YRVGQSKIFFRAGVLAQLEEERDLKVTDIIVSFQAAARG--YLARRAFQ
R-RQQQQSALRVMQRNCAAYLKLRHWQWWR-----------------LFIKV--KPLLQV

PF01576 // ENSGT00760000118919_8_Domain_13 (1081, 2504)

TR--QDEVLQARAQELQKVQELQQQSARQVGELQDRVAQLEEERTRLAEQLRAEAELCAE
A---EETRGRLATRKQ-ELELVVTEL----EAR-------MGEEEECSRQLQAEKRRLQL
HIQELETHL------------EAEEGARQKLQLEKVTTEARLKKFEE-DLLLLE---DQN
AKLGKERRLLEERLAEFSSAAAE--------EEEKIKSLNKLRLKYEATIADMEDRLRKE
EKGRQELEKLKRRLDGESSE-LQEQMAGQQQRAEE-LRAQLGR--KEEELQAALARAEEE
GGARTQLLKSLREAQAGLAEAQEDLEAERAARAKAEKHRRDLGEELEALRGELEDTLDST
NAQQELR---TKREQEVTELKKTLEEETRIHEVAVQELRQRHGQALGELAEQLEQARRG-
--KGAWEKTRLALEAEVSELRAELSSLQSARQEGEQRRRRLESQLQ--------------
------------------EVQG------RAGDGERARVE---------------------
-AAEKLQRAQVSGVSVTARPAPRTP------------APRAPQPSELLQEETRAKLALGS
RVRALEAE-------------------------------ASGLREQIEEEAAARERAGRE
----------LQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALAQ-----RLAE
KTEAAE---RLERGRRR-----------LQQELDDA------------------TVDLE-
---QQRQLVSSLEKKQRKFDQLL----------AEEKAAVLRAAEERERVEAEGREREAR
ALSLTRALEEEQEAREE-----------------------LERQNRALRAEMEALLSSKD
DVGKSVHELERARRVA--------EQAAN-DLRAQVTELED----ELTAA-EDAKLRLEV
TV---QALKAQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEE-RKQRALALAARK-KL
EAELEELKAQMAA-----------A-GQGKEEAVKQL---RK------------------
-MQA-QMKELWREVEESRTS-REEIF-VQNRESEKRLKGLEADVLRLQEELAASDRARRQ
AQQDRDEMADELANGSLSKAALLEEKRQLEGRLGQLEEELEEEQSNAELLNDRYRKLLLQ
VETLTT---------ELSAERSFSAKAESGRQQLERQIQELRGHLGEEDAGARAR--QKM
MIATLESKLAQAEEQLEQET----------------------------------------
----------RERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRLKQLKR
QLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLRYGGGGLCPGWGRLGP
AGTEGAEPRSRGVREELGHRHFRSPLFCHARVSARRRGPLTFTTRTVRQVFRLEEGVASD
EEE-VEGAEPGSAL-PQEPECPPPAQPQ--

MAAVTMSVPGRKAPPRPGPVPEAAQPFLFTPRGPSAGG----GPG-SGTSPQVEWTAR

PF02736 // ENSGT00760000118919_8_Domain_0 (59, 98)

RL
VW--VPSELHGFEAAALRDEGEEEAEVELAESGRRLR

ENSGT00760000118919_8_Linker_0_1 (98, 115)

LPRDQIQRMNPPKFSKA

PF00063 // ENSGT00760000118919_8_Domain_1 (115, 933)

EDMAEL
TCLNEASVLHNLRERYYSGLIYTYSGLFCVVINPYKQLPIYTEAIVEMYRGKKRHEVPPH
VYAVTEGAYRSMLQDR-EDQSILCTGESGAGKTENTKK--V---IQ-------YLAHVAS
SPKGRKEP-------GVP-----------------------------ASVSTVSYGELER
QLLQANPILEAFGNAKTVKNDNSS-RFGK------FIRINFDVAGYIVGANI--ETYLLE
KSRAIRQAKDECSFHI----FYQLLGGAG--EQLKADLLLEPCSQYRFLTNGPSSSPGQE
RE-LFQETLESLRVLGFTHEEIISMLRMVSAVLQFGNIALKRERNTDQATMPDNTAAQKL
CRLLGLGVTDFSRALLTPRIK-VGRDYV----QKAQTKEQADFALEALAKATYERLFRWL
VLRLNRALDRSPRQGASFLGILDIAGFEIFQLNSFEQLCINY-TNEKLQQLFNHTMFVL-
-EQEEYQREGIPWTFLDFGLDLQPCIDLIER-------------PANPPGLLALLDEECW
FPKATDK-SFVEKVAQEQGGHPKFQRPRQLRDQADFSVLHYAGKVDYKANEWLMKNMDPL
NDNVAALLHQSTDRLTAEIWKDEHGGFQQFSFLGSFPPSPPGSAERCSSAVSPPGV----
-------------EGIVGLEQVSSLGDG-P-P-GGRPRRGMFRTVGQLYKESLSRLMATL
SNTNPSFVRCIVPNHEKRAGKLEPR---------LVL-----DQLRCNGVLEGIRICRQG
FPNRI-------------------LF--QEFRQ---------------------------
IQALELDPNL-YRVGQSKIFFRAGVLAQLEEERDLKVTDIIVSFQAAARG--YLARRAFQ
K-RQQQQSALRVMQRNCAAYLKLRHWQWWR-----------------LFTKV--KPLLQV

PF01576 // ENSGT00760000118919_8_Domain_14 (1081, 1498)

TR--QDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERTRLAEQLRAEAELCAE
A---EETRGRLAARKQ-ELELVVSEL----EAR-------VGEEEECSRQLQTEKRRLQQ
HIQELEAHL------------EAEEGARQKLQLEKVTTEAKMKKFEE-DLLLLE---DQN
SKLSKERKLLEDRLSEFSSQAAE--------EEEKVKSLNKLRLKYEATIADMEDRLRKE
EKGRQELEKLKRRLDGESSE-LQEQMVEQQQRAEE-LRAQLGR--KEEELQAALARAEDE
GGARAQLLKSLREAQAALAEAQEDLEAERVARTKAEKQRRDLGEELEALRSELEDTLDST
NAQQELR---SKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARR--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------LL----------AEEKAAVLRAVEERERAEAEGREREAR
ALSLTRALEEEQEAREE-----------------------LERQNRALRAELEALLSSKD
DVGKSVHELERACRVA--------EQAAN-DLRAQVTELED----ELTAA-EDAKLRLEV
TV---QALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEE-RKQRTLAVAARK-KL
EGELEELKAQMAS-----------A-GQGKEEAVKQL---RK------------------
-MQA-QMKELWREVEETRSS-REEIF-SQNRESEKRLKGLEAEVLRLQEELAASDRARRQ
AAQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQ
VESLTT---------ELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARAR--HKM
TIAALESKLAQAEEQLEQET----------------------------------------
----------RERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKR
QLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLR---------------
------------------------------------RGPLTFTTRTVRQVFRLEEGVASD
EE--TEEAEPGSGPS-PEPEGSPPAHPQ--

MAAVTMSVPGRKAPPRPGPVPEAAQPFLFTPRGPSAGG----GPG-SGTSPQVEWTAR

PF02736 // ENSGT00760000118919_8_Domain_0 (59, 98)

RL
VW--VPSELHGFEAAALRDEGEEEAEVELAESGRRLRLPRDQIQRMNPPKFSKAEDMAEL
TCLNEASVLHNLRERYYSGLIYTYSGLFCVVINPYKQLPIYTEAIVEMYRGKKRHEVPPH
VYAVTEGAYRSMLQDR-EDQSILCTGESGAGKTENTKK--V---IQ-------YLAHVAS
SPKGRKEPGVPVST----------------------------------------PGELER
QLLQANPILEAFGNAKTVKNDNSS-RFGK------FIRINFDVAGYIVGANI--ETYLLE
KSRAIRQAKDECSFHI----FYQLLGGAG--EQLKGQYL-ASVARWVLLRSGSSSVPGLA
RGPQPHMT--S-------VLVSPAMLRMVSAVLQFGNIALKRERNTDQATMPDNTAAQKL
CRLLGLGVTDFSRALLTPRIK-VGRDYV----QKAQTKEQADFALEALAKATYERLFRWL
VLRLNRALDRSPRQGASFLGILDIAGFEIFQVRPRAGRGMPT-----------SSLRSW-
-SFL

PF00063 // ENSGT00760000118919_8_Domain_5 (605, 860)

EYQREGIPWTFLDFGLDLQPCIDLIER-------------PANPPGLLALLDEECW
FPKATDK-SFVEKVAQEQGGHPKFQRPRQLRDQADFSVLHYAGKVDYKANEWLMKNMDPL
NDNVAALLHQSTDRLTAEIWKDEHGGFQQFSFLGSFP---------PSPPGSAVRCSSAV
SP--------PGVEGIVGLEQVSSLGDG-P-P-GGRPRRGMFRTVGQLYKESLSRLMATL
SNTNPSFVRCIVPNHEKRA

ENSGT00760000118919_8_Linker_5_10 (860, 934)

GGSLEP-----------------------------------
----------------------------RRQRL

PF00063 // ENSGT00760000118919_8_Domain_10 (934, 982)

QYEILTPNA---IPKGFMDGKQACEKM
IQALELDPNL-YRVGQSKIFFRAGVLAQLEEERDLKVTDIIVSFQAAARG--YLARRAFQ
K-RQQQQSALRVMQRNCAAYLKLRHWQWWR-----------------LFTKV--KPLLQV

PF01576 // ENSGT00760000118919_8_Domain_13 (1081, 2449)

TR--QDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERTRLAEQLRAEAELCAE
A---EETRGRLAARKQ-ELELVVSEL----EAR-------VGEEEECSRQLQTEKKRLQQ
HIQELEAHL------------EAEEGARQKLQLEKVTTEAKMKKFEE-DLLLLE---DQN
SKLSKERKLLEDRLSEFSSQAAE--------EEEKVKSLNKLRLKYEATIADMEDRLRKE
EKGRQELEKLKRRLDGESSE-LQEQMVEQQQRAEE-LRAQLGR--KEEELQAALARAEDE
GGARAQLLKSLREAQAALAEAQEDLEAERVARTKAEKQRRDLGEELEALRSELEDTLDST
NAQQELR---SKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRG-
--KGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLESQLQ--------------
------------------EVQG------RAGDGERARAE---------------------
-AAEKLQRAQAELENVSGALNEAESKAIRLRKELSSTEAQLHDAQELLQEETRVKLALGS
RVRAMEAE-------------------------------AAGLREQLEEEAAARERAGRE
----------LQTTQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQ-----RLAE
KTETVD---RLERGRRR-----------LQQELDDA------------------TMDLE-
---QQRQLVSTLEKKQRKFDQLL----------AEEKAAVLRAVEERERAEAEGREREAR
ALSLTRALEEEQEAREE-----------------------LERQNRALRAELEALLSSKD
DVGKSVHELERACRVA--------EQAAN-DLRAQVTELED----ELTAA-EDAKLRLEV
TV---QALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEE-RKQRTLAVAARK-KL
EGELEELKAQMAS-----------A-GQGKEEAVKQL---RK------------------
-MQA-QMKELWREVEETRSS-REEIF-SQNRESEKRLKGLEAEVLRLQEELAASDRARRQ
AAQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQ
VESLTT---------ELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARAR--HKM
TIAALESKLA--------------------------------------------------
----------------------------------------------QLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLR---------------------------------------------------RGPLTFTTRTVRQVFRLEEGVASDEE--TEEAEPGSGPS-PEPEGSPPAHPQ

PF01576 // ENSGT00760000118919_8_Domain_19 (2447, 2504)

QLEKGNLRVKQLKR
QLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLR---------------
------------------------------------RGPLTFTTRTVRQVFRLEEGVASD
EE--TEEAEPGSGPS-PEPEGSPPAHPQ--

MAAVTMSASGRKVASRPGPVPEAAQSFLFAPRTPNVGG----PG-----GPQVEWTAR

PF02736 // ENSGT00760000118919_8_Domain_0 (59, 98)

RM
VW--VPSELHGFEAAALRDEGEEEAEVELAESGRRLR

ENSGT00760000118919_8_Linker_0_1 (98, 115)

LPRDQIQRMNPPKFSKA

PF00063 // ENSGT00760000118919_8_Domain_1 (115, 982)

EDMAEL
TCLNEASVLHNLRERYYSGLIYTYSGLFCVVINPYKQLPIYTEAIVEMYRGKKRHEVPPH
VYAVTEGAYRSMLQDR-EDQSILCTGESGAGKTENTKK--V---IQ-------YLAHVAS
SPKGRKEPGVPVSHTASGHSRHITSSIFYFGLHSTFTAGARPYVFLCYLSTYCVLGELER
QLLQANPILEAFGNAKTVKNDNSS-RFGK------FIRINFDTAGYIVGANI--ETYLLE
KSRAIRQAKDECSFHI----FYQLLGGAG--EQLKADLLLEPCSHYRFLTNGPSSSPGQE
RE-LFQETLESLRVLGLLPEEITAMLRTVSAVLQFGNIVLKKERNTDQATMPDNTAAQKL
CRLLGLGVTDFSRALLTPRIK-VGRDYV----QKAQTKEQADFALEALAKATYERLFRWL
VLRLNRALDRSPRQGASFLGILDIAGFEIFQLNSFEQLCINY-TNEKLQQLFNHTMFVL-
-EQEEYQREGIPWTFLDFGLDLQPCIDLIER-------------PANPPGLLALLDEECW
FPKATDK-SFVEKVAQEQGSHPKFQRPRNLRDQADFSVLHYAGKVDYKASEWLMKNMDPL
NDNVAALLHQSTDRLTAEIWK---------------------------------------
-----------DVEGIVGLEQVSSLGDG-P-P-GGRPRRGMFRTVGQLYKESLSRLMATL
SNTNPSFVRCIVPNHEKRAGKLEPR---------LVL-----DQLRCNGVLEGIRICRQG
FPNRI-------------------LF--QEFRQRYEILTPNA---IPKGFMDGKQACEKM
IQALELDPNL-YRVGQSKIFFRAGVLAQLEEERDLKVTDIIVSFQAAARG--YLARRAFQ
R-RQQQQSALRVMQRNCAAYLKLRNWQWWR-----------------LFIKV--KPLLQV

PF01576 // ENSGT00760000118919_8_Domain_13 (1081, 2504)

TR--QDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERTRLAEQLRAEAELCSE
A---EETRARLAARKQ-ELELVVTEL----EAR-------VGEEEECSRQLQSEKKRLQQ
HIQELESHL------------EAEEGARQKLQLEKVTTEAKMKKFEE-DLLLLE---DQN
SKLSKERRLLEERLAEFSSQAAE--------EEEKVKSLNKLRLKYEATISDMEDRLKKE
EKGRQELEKLKRRLDGESSE-LQEQMVEQKQRAEE-LLLQLGR--KEDELQAALLRAEEE
GGARAQLLKSLREAQAGLAEAQEDLEAERVARAKAEKQRRDLGEELEALRGELEDTLDST
NAQQELR---SKREQEVTELKKALEEESRAHEVSMQELRQRHSQALVEMAEQLEQARRG-
--KGVWEKTRLALEAEVSELKAELSSLQTSRQEGEQKRRRLESQLQ--------------
------------------EVQG------RSSDSERARSE---------------------
-AAEKLQRAQAELESVSTALSEAESKAIRLGKELSSAESQLHDTQELLQEETRAKLALGS
RVRALEAE-------------------------------AAGLREQMEEEVVARERAGRE
----------LQSMQAQLSEWRRRQEEEASVLEAGEEARRRAAREAETLAQ-----RLAE
KTEAVE---RLERARRR-----------LQQELDDA------------------TVDLG-
---QQKQLLSTLEKKQRKFDQLL----------AEEKAAVLRAVEDRERIEAEGREREAR
ALSLTRALEEEQEAREE-----------------------LERQNRALRAELEALLSSKD
DVGKNVHELERARKVA--------EQAAS-DLRTQVTELED----ELTAA-EDAKLRLEV
TV---QALKAQHERDLQGRDDAGEERRRQLAKQLRDAEVERDEE-RKQRALAMAARK-KL
ELELEELKAQTSA-----------A-GQGKEEAVKQL---KK------------------
-MQA-QMKELWREVEETRTS-RDEMF-TLSRENEKRLKGLEAEVLRLQEELAASDRARRQ
AQQDRDEMAEEVASGNLSKAATLEEKRQLEVRLGQLEEELEEEQNNSELLKDHYRKLVLQ
VESLTT---------ELSAERSFSAKAESGRQQMERQIQELRARLGEEDAGARAR--QKM
LIAALESKLAQAEEQLEQES----------------------------------------
----------RERILSGKLVRRAEKRLKEVVLQVDEERRVADQVRDQLEKSNLRLKQLKR
QLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLR---------------
------------------------------------RGPLTFTTRTVRQVFRLEEGVASD
EEE-AEGAEPGSTPA-QESEAPPPATPQ--

MAAVSGTVPGWKAPPRPGPVPEAAQPFLFAPRGPGAGI----GPGGSATSPQVEWTA

PF02736 // ENSGT00760000118919_8_Domain_0 (58, 102)

RRL
VW--VPSELHGLEAAALRDEGEEEAEVELAESGRRLRLPRD

ENSGT00760000118919_8_Linker_0_1 (102, 114)

QIQRINPPKFSK

PF00063 // ENSGT00760000118919_8_Domain_1 (114, 982)

AEDMAEL
TCLNEASVLHNLRERYYSGLIYTYSGLFCVVINPYKQLPIYTEAIVEMYRGKKRHEVPPH
VYAVTEGAYRSMLQDR-EDQSILCTGESGAGKTENTKK--V---IQ-------YLAHVAS
SPKGRKEPGVP--------------------------------------------GELER
QLLQANPILEAFGNAKTVKNDNSS-RFGK------FIRINFDVAGYIVGANI--ETYLLE
KSRAIRQAKDECSFHI----FYQLLGGAG--EQLKADLLLEPCSHYRFLTNGPASSPGQE
RE-LFQETLESLRVLGFTHEEITSMLRMVSAVLQFGNIVLKKERNTDQASMPDNTAAQKL
CRLLGLGVTDFSRALLTPRIK-VGRDYV----QKAQTKEQADFALEALAKATYERLFRWL
VLRLNRALDRSPRQGASFLGILDIAGFEIFQLNSFEQLCINY-TNEKLQQLFNHTMFIL-
-E-EEYQREGIPWTFLDFDLDLQPCIDLIER-------------PANPPGLLALLDEECW
FPKATDK-SFVEKVAQEQGGHPKFQRPRHLRDQADFSVLHYAGKVDYKANEWLMKNMDPL
NDSVAALLHQSTDRLTAEIWKDARGGFQRFSLLGSFP---------PSPPGSSGRCSSAI
SP--------PGVEGIVGLEQVSSLGDG-P-P-GGRPRRGMFRTVGQLYKESLSRLMATL
SNTNPSFVRCIVPNHEKRXXXXXXX---------XXX-----XXXXXXXXXXXXXXXXXX
XXXXX-------------------XX--XXXXXXYELLTPNA---IPKGFMDGKQACEKM
IQALELDPNL-YRV-QSKIFFRAGVLTQLGGERDL-VTDIIVSFQAAARXXXXXXXXXXX
----XXXXXXXXXMQRCAAYLKLRHWQWWR-----------------LFIKV--KPLLQV
TR--QDEVLQARAQELQKVQELQQQSAREVGELQGRLAQLEEERARLAEQLRAEAELCSE
A---EETRGRLAARKQ-ELELVVAEL----EAR-------VGEEEECSRQLQSEKKRLQQ
HIQELETHL------------EAEEGARQKLQLEKVTTEAKLKKFEE-DLLLLE---DQN
AKLSKERRLLEDRLSEFSSQAAE--------EEEKIKSLNKLRLKYEATMADMEDRLRKE
EKGRQELEKLKRRLDGESSE-LQEQMA

PF01576 // ENSGT00760000118919_8_Domain_13 (1348, 2557)

EQQQRVEE-LRAQLGR--KEEELQAALTRAEEE
GGARAQLLKSLREAQAGLAEAQEDLEAERLARAKAEKQRRDLGEELEALRGELEDTLDST
NAQQELR---SKREQEVTELKKALEEETRIHEVTVQELRQRHGQALGELAEQLEQARRG-
--KGVWEKTRLALETEVSELRTELSNLQSTRQEGEQRRRRLESQLQ--------------
------------------EAQG------RAGDGERARAE---------------------
-LAEKLQRAQTELENVSGALNEAESRAIRLSKELSSTEVQLHDGQELLQEETRAKLALGS
RVRALEAE-------------------------------VAGLREQLEEEAAARERAGRE
----------LQTAQVQLSEWRRRQEEEAGALEAGEEARRRAAREAEALAQ-----RLTE
KTETVE---RLERGRRR-----------LQQELDDA------------------TVDLE-
---QQRQLVGSLEKKQRKFDQLL----------AEEKAAVLRAVEERERAEAEGREREAR
ALSLARALEEEQEARGE-----------------------LERQTRALRAELEALLSSKD
DVGKSVHELERARRVA--------EQAAS-DLRTQVTELED----ELMAA-EDAKLRLEV
TV---QALKAQHERDLQGRDEAGEERRRQLAKQLDAXXXXXXXX-XXXXXXXXXXXX-XX
X-XXXXXXXXXXX-----------X-XXXXXXXXXXX---XX------------------
-XXA-QMKELWREVEESRSS-REEIF-AQNRESDKRLKGLEAEVLRLQEELAASDRARRQ
AQQERDEMADEVANGNLSKAALLDEKRQLEGRLGQMEEDLEEEQSNAELLGDRYRKLLLQ
VESLTT---------ELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARAR--QKM
TIAALESKLAQAEEQLEQES----------------------------------------
----------RERILSGKLVRRAEKRLKEVVLQAEEERRVGDHLRDQLEKGNLRVKQLKR
QLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLR---------------
------------------------------------RGPLTFTTRTVRQVFRLEEGVASK
EEA---EAYPGSGPA-PEPNWAPEAQPH--

MAAVTMSVPGRKAPPRPGPVPEAAQPFLFTPRGPSAGG----GPG-SGTSPQVEWTA

PF02736 // ENSGT00760000118919_8_Domain_0 (58, 102)

RRL
VW--VPSELHGFEAAALRDEGEEEAEVELAESGRRLRLPRD

ENSGT00760000118919_8_Linker_0_1 (102, 115)

QIQRMNPPKFSKA

PF00063 // ENSGT00760000118919_8_Domain_1 (115, 982)

EDMTEL
TCLNEASVLHNLRERYYSGLIYTYSGLFCVVINPYKQLPIYTEAIVEMYRGKKRHEVPPH
VYAVTEGAYRSMLQDR-EDQSILCTGESGAGKTENTKK--V---IQ-------YLAHVAS
SPKGRKEP-------GVP-----------------------------ASVSTVSYGELER
QLLQANPILEAFGNAKTVKNDNSS-RFGK------FIRINFDVAGYIVGANI--ETYLLE
KSRAIRQAKDECSFHI----FYQLLGGAG--EQLKADLLLEPCSQYRFLTNGPSSSPGQE
RE-LFQETLESLRVLGFTHEEIISMLRMVSAVLQFGNIALKRERNTDQATMPDNTAAQKL
CRLLGLGVTDFSRALLTPRIK-VGRDYV----QKAQTKEQADFALEALAKATYERLFRWL
VLRLNRALDRSPRQGASFLGILDIAGFEIFQLNSFEQLCINY-TNEKLQQLFNHTMFVL-
-EQEEYQREGIPWTFLDFGLDLQPCIDLIER-------------PANPPGLLALLDEECW
FPKATDK-SFVEKVAQEQGGHPKFQRPRQLRDQADFSVLHYAGKISGKASQKKICSISNL
SQGPANVFCKGSDIFTQEIGKQEHGGFQQFSFLGSFPPSPPGSAERCSSAVSPPGV----
-------------EGIVGLEQVSSLGDG-P-P-GGRPRRGMFRTVGQLYKESLSRLMATL
SNTNPSFVRCIVPNHEKRAGKLEPR---------LVL-----DQLRCNGVLEGIRICRQG
FPNRI-------------------LF--QEFRQRYEILTPNA---IPKGFMDGKQACEKM
IQALELDPNL-YRVGQSKIFFRAGVLAQLEEERDLKVTDIIVSFQAAARG--YLARRAFQ
K-RQQQQSALRVMQRNCAAYLKLRHWQWWR-----------------LFTKV--KPLLQV
TR--QDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERTRLAEQLRAEAELCAE
A---EETRGRLAARKQ-ELELVVSEL----EAR-------VGEEEECSRQLQTEKRRLQQ
HIQELEAHL------------EAEEGARQKLQLEKVTTEAKMKKFEE-DLLLLE---DQN
SKLSKERKLLEDRLSEFSSQAAE--------EEEKVKSLNKLRLKYEATIADMEDRLRKE
EKGRQELEKLKRRLDGESSE-LQEQMVE

PF01576 // ENSGT00760000118919_8_Domain_13 (1349, 2557)

QQQRAEE-LRAQLGR--KEEELQAALARAEDE
GGARAQLLKSLREAQAALAEAQEDLETERVARTKAEKQRRDLGEELEALRSELEDTLDST
NAQQELR---SKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRG-
--KGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLESQLQ--------------
------------------EVQG------RAGDGERARAE---------------------
-AAEKLQRAQAELENVSGALNEAESKAIRLSKELSSTEAQLHDAQELLQEETRAKLALGS
RVRAMEAE-------------------------------AAGLREQLEEEAAARERAGRE
----------LQSTQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQ-----RLAE
KTETVD---RLERGRRR-----------LQQELDDA------------------TMDLE-
---QQRQLVSTLEKKQRKFDQLL----------AEEKAAVLRAVEERERAEAEGREREAR
ALSLTRALEEEQEAREE-----------------------LERQNRALRAELEALLSSKD
DVGKSVHELERACRVA--------EQAAN-DLRAQVTELED----ELTAA-EDAKLRLEV
TV---QALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEE-RKQRTLAVAARK-KL
EGELEELKAQMAS-----------A-GQGKEEAVKQL---RK------------------
-MQA-QMKELWREVEETRSS-REEIF-SQNRESEKRLKGLEAEVLRLQEELAASDRARRQ
AQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQ
VESLTT---------ELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARAR--HKM
TIAALESKLAQAEEQLEQET----------------------------------------
----------RERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKR
QLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLR---------------
------------------------------------RGPLTFTTRTVRQVFRLEEGVASD
EE--TEEAEPGSGPS-PEPEGSPPAHPQ--

------------------------------------------------------------
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---------------------------

PF00063 // ENSGT00760000118919_8_Domain_1 (148, 744)

FCVVINPYKQLPIYTEAIVEMYRGKKRHEVPPH
VYAVTEGAYRSMLQG-------ECGGESGAGKTENTKK--V---IQ-------YLAHVAS
SPKGRKEP-------GVP-------------------------------------GELER
QLLQANPILEAFGNAKTVKNDNSS-RFGK------FIRINFDVAGYIVGANI--ETYLLE
KSRAIRQAKDECSFHI----FYQLLGGAG--EQLKADLLLEPCSNYRFLTNGPSSSPGQE
RE-LFQETLESLRVLGFAPEEITSMLRTVSAVLQFGNVVLKSERNTDQATMPDNTAAQKL
CRLLGLGVTDFSRALLTPRIK-VGRDYV----QKAQSKEQADFALEALAKATYERLFRWL
VLRLNRALDRSPRQGASFLGILDIAGFEIFQLNSFEQLCINY-TNEKLQQLFNHTMFVL-
-EQEEYQREGIPWTFLDFGLDLQPCIDLIER-------------PANPPGLLALLDEECW
FPKATDK-SFVEKVAQEQGSHPKFQRPRHLRDQADFSVLHYAGKVDYKANEWLMKNMDPL
NDNVAALLHQSTDRLTAEIWKDE

ENSGT00760000118919_8_Linker_1_9 (744, 892)

HGGLQQLSFLGSFP---------PSPPGSAGRRGSDT
PLPGGGCPCASTGEAAGQ--------------------GGWTVGLGTWFEHHPAPLL---
-----------------SAGGLSLP---------LPP-----CRPLLHNLP

PF00063 // ENSGT00760000118919_8_Domain_9 (892, 982)

KGIRICRQG
FPNRI-------------------LF--QEFRQRYEILTPNA---IPKGFMDGKQACEKM
IQALELDPNL-YRVGQSKIFFRAGVLAQLEEERDLKVTDIIVSFQAAARG--YLARRAFQ
R-RQQQQSALRVMQRNCAAYLKLRHWQWWR-----------------LFIKV--KPLLQV

PF01576 // ENSGT00760000118919_8_Domain_14 (1081, 1473)

TR--QDEVLQARAQELQKVQELQQQSARE----------LEEERTRLAEQLRAEAELCAE
A---EETRGRLAARKQ-ELELVVSEL----EAR-------MGEEEECSRQLQTEKKRLQQ
HIQELETHL------------EAEEGARQKLQLEKVTTEAKLKKFEE-DLLLLE---DQN
AKLSKERRLLEERLAEFSSQAAE--------EEEKVKSLNKLRLKYEATIADMEDRLRKE
EKGRQELEKLKRRLDGESSE-LQEQMVEQQQRAEE-LRAQLGR--KEEELQAALARAEEE
GGARAQLLKSLREAQAGLAEAQEDLEAERAARAKAEKQRRDLGEELEALRGELEDTLDST
NAQQELR---SKREQEVTELKKALEEETRVHEV---------------------------
--------------AEVSELRAELSSLQTARQEGEQKRRRLESQLQ--------------
------------------EVQG------RAGDGERARVE---------------------
-AAEKLQRAQAELENVSGALSEAESKAIRLGKELSSTEAQLHDTQELLQEETRAKLALGS
RVRAVEAE-------------------------------VAGLREQLEEEAAARERAGRE
----------LQTAQAQLADWRRRQEEEAGALEAGEEARRRAAREAEALAQ-----RLAE
KTEAVE---RLERGRRR-----------LQQELDDV------------------TVDLE-
---QQRQLVSTLEKKQRKFDQLL----------AEEKAAVLRAVEERERVEAEGREREAR
ALSLTRALEEEQEAREE-----------------------LERQNRALRAELEALLSSKD
DVGKSVHELERARRVA--------EQAAS-DLRTQVTELED----ELTAA-EDAKLRLEV
TV---QALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEE-RKQRALAVAARK-KL
EAELEELKAQTTA-----------A-GQGKEEAVKQL---RK------------------
-MQA-QMKELWREVEESRSS-REEIF-VQSRESEKRLKALEAEVLRLQEELAASDRARRQ
AQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQMEEELEEEQSNAELLNDRYRKLLLQ
VETLTT---------ELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARAR--QKM
VIAALESKLAQAEEQLEQES----------------------------------------
----------RERILSGKLVRRAEKRLKEVVMQVEEERRVADQLRDQLEKGNLRVKQLKR
QLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLR---------------
------------------------------------RGPLTFTTRTVRQVFRLEKGVASD
EEE-AQEAEPGSGPPPPEPEGPPPAQPQ--

MAAVTLSVPGRKVVSRPGPVPEAAQPFLFAPRTPNVGG----PG-----GPQVEWTAR

PF02736 // ENSGT00760000118919_8_Domain_0 (59, 98)

RL
VW--VPSELHGFEAAALRDEGEEEAEVELAESGRRLR

ENSGT00760000118919_8_Linker_0_1 (98, 115)

LPRDQIQRMNPPKFSKA

PF00063 // ENSGT00760000118919_8_Domain_1 (115, 982)

EDMAEL
TCLNEASVLHNLRERYYSGLIYTYSGLFCVVINPYKQLPIYTEAIVEMYRGKKRHEVPPH
VYAVTEGAYRSMLQDR-EDQSILCTGESGAGKTENTKK--V---IQ-------YLAHVAS
SPKGRKEPGVPASIST------------------------------------MSYGELER
QLLQANPILEAFGNAKTVKNDNSS-RFGK------FIRINFDVAGYIVGANI--ETYLLE
KSRAIRQAKDECSFHI----FYQLLGGAG--EQLKADLLLEPCSHYRFLTNGPSSSPGQE
RE-LFQETLESLRVLGFLPDEITAMLRTVSAVLQFGNVVLKRERNTDQATMPDNTAAQKL
CRLLGLGVTDFSRALLTPRIK-VGRDYV----QKAQTKEQADFALEALAKATYERLFRWL
VLRLNRALDRSPRQGASFLGILDIAGFEIFQLNSFEQLCINY-TNEKLQQLFNHTMFVL-
-EQEEYQREGIPWTFLDFGLDLQPCIDLIER-------------PANPPGLLALLDEECW
FPKATDK-SFVEKVAQEQGSHPKFQRPRHLRDQADFSVLHYAGKVDYKANEWLMKNMDPL
NDNVAALLHQSTDRLTAEIWKD--------------------------------------
------------VEGIVGLEQVSSLGDG-P-P-GGRPRRGMFRTVGQLYKESLSRLMATL
SNTNPSFVRCIVPNHEKRAGKLEPR---------LVL-----DQLRCNGVLEGIRICRQG
FPNRI-------------------LF--QEFRQRYEILTPNA---IPKGFMDGKQACEKM
IQALELDPNL-YRVGQSKIFFRAGVLAQLEEERDLKVTDIIVSFQAAARG--YLARRAFQ
R-RQQQQSALRVMQRNCAAYLKLRNWQWWR-----------------LFIKV--KPLLQV

PF01576 // ENSGT00760000118919_8_Domain_13 (1081, 2504)

TR--QDEVLQARAQELQKVQELQQQSAREVEELQSRVVQLEEERSRLAEQLRAEAELCSE
A---EETRARLSARKQ-ELELVVSEL----EAR-------VGEEEECSRQLQGEKKRLQQ
HIQELETHL------------EAEEGARQKLQLEKVTTEAKMKKFEE-DLLLLE---DQN
AKLSKERRLLEERLAEFSSQAAE--------EEEKVKSLNKLRLKYEATITDMEDRLKKE
EKGRQELEKLKRRLDGESSE-LQEQMVEQKQRAEE-LLAQLGR--KEDELQAALVRAEEE
GSARAQLLKSLREAQAGLAEAQEDLEAERTARAKAEKQRRDLGEELEALRGELEDTLDST
NAQQELR---SKREQEVTELKKTLEEEARAHEVAMQELRQRHGQALGELAEQLEQARR--
-GKGVWEKTRLTLEAEVSELRAELSGLQTSRQEGEQKRRRLESQLQ--------------
------------------EVQG------RASDVERARTE---------------------
-AAEKLQRAQAELESVSTALSEAESKAIRLGKELSSAESQLHDAQELLQEETRAKLALGS
RVRALEAE-------------------------------AAGLREQMEEEVVARERAGRE
----------LQSAQAQLSEWRRRQEEEAGVLEAGEEARRRAAREAEALAQ-----RLAE
KTEAVE---RLERARRR-----------LQQELDDA------------------TVDLG-
---QQKQLLSTLEKKQRKFDQLL----------AEEKAAVLRAVEDRERVEAEGREREAR
ALSLTRALEEEQEAREE-----------------------LERQNRALRAELEALLSSKD
DVGKNVHELERARRVA--------EQAAS-DLRTQVTELED----ELTAA-EDAKLRLEV
TV---QALKAQHERDLQGRDDAGEERRRQLAKQLRDAEVERDEE-RKQRALAVAARK-KL
EAELEELKAQTSA-----------A-GQGKEEAVKQL---RK------------------
-MQA-QMKELWREVEETRSS-REEIF-TLNKESEKRLKGLEAEVLRLQEELAASDRARRQ
AQQDRDEMAEEVANGNLSKAAVLEEKRQLEGRLGQLEEELEEEQNNSELLKDHYRKLLLQ
VESLTT---------ELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGTRAR--QKM
LIAALESKLAQAEEQLEQES----------------------------------------
----------RERILSGKLVRRAEKRLKEVVLQVDEERRVADQLRDQLEKGNLRLKQLKR
QLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLR---------------
------------------------------------RGPLTFTTRTVRQVFRLEEGVASD
EEE-AEGAESGPAPP-QEPEAPPPATPQ--

MAAMTLSVPGRKAPPRPGPVPEAAQPFLFAPRGPA--G----GPGALGASPPVEWTA

PF02736 // ENSGT00760000118919_8_Domain_0 (58, 102)

RRL
VW--VPSELHGFEAAALRDEGEEEAEVELAESGRRLRLPRD

ENSGT00760000118919_8_Linker_0_1 (102, 115)

QVQRMNPPKFSKA

PF00063 // ENSGT00760000118919_8_Domain_1 (115, 860)

EDMAEL
TCLNEASVLHNLRERYYSGLIYTYSGLFCVVINPYKQLPIYTEAIVEMYRGKKRHEVPPH
VYAVTEGAYRSMLQDR-EDQSILCTGESGAGKTENTKK--V---IQ-------YLAHVAA
SPKGRKDPGVPASTSTL------------------------------------SYGELER
QLLQANPVLEAFGNAKTVKNDNSS-RFGK------FIRINFDVAGYIVGANI--ETYLLE
KSRAIRQATDECSFHI----FYQLLGGAG--EQLKADLLLEPCSQYRFLTNAPAASPGQE
RE-LFQETLESLRVLGFTHEEITSMLRTVSAVLQFGNVALRKERNTDQATMPDNTAAQKL
CRLLGLGVTDFSRALLTPRIR-VGRDYV----QKAQTKEQADFALEALAKATYERLFRWL
VLRLNRALDRSPRQGASFLGILDIAGFEIFQLNSFEQLCINY-TNEKLQQLFNHTMFVL-
-EQEEYQREGIPWTFLDFGLDLQPCIDLIER-------------PANPPGLLALLDEECW
FPKATDK-SFVEKVAQEQGGHPKFQRPRHLRDQADFSVLHYAGKVDYKANEWLMKNMDPL
NDNVAALLHQSTDRLTAEIWK---------------------------------------
-----------DVEGIVGLEQVSSLGDG-P-P-GGRPRRGMFRTVGQLYKESLSRLMATL
SNTNPSFVRCIVPNHEKRVSDSACG---------Q--------GAVGRGPAPGLAECRLP
APDLP-------------------RL--RALW-KYSPVHSTC---IY-------------
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MAAVTMSVPGRKAPPRPGPVPEAAQPFLFTPRGPSAGG----GPG-SGTSPQVEWTAR

PF02736 // ENSGT00760000118919_8_Domain_0 (59, 98)

RL
VW--VPSELHGFEAAALRDEGEEEAEVELAESGRRLR

ENSGT00760000118919_8_Linker_0_1 (98, 115)

LPRDQIQRMNPPKFSKA

PF00063 // ENSGT00760000118919_8_Domain_1 (115, 965)

EDMAEL
TCLNEASVLHNLRERYYSGLIYTYSGLFCVVINPYKQLPIYTEAIVEMYRGKKRHEVPPH
VYAVTEGAYRSMLQGIGEDQSILLSGSWGNGKH---RK--V---IQ-------YLPNPGV
SRK----P-------PQP------------------------------WDTPLGPGTLER
QLLQANPILEAFGNAKTVKNDNSS-RFGK------FIRINFDVAGYIVGANI--ETCILS
------QAKRRVRLHI----FYQLLRGGAGESSSKADLLLEPCSQYRFLTNGPSSSPGQE
RE-LFQETLESLRVLGFTHEEIISMLRMVSAVLQFGNIALKRERNTDQATMPDNTAAQKL
CRLLGLGVTDFSRALLTPRIK-VGRDYV----QKAQTKEQADFALEALAKATYERLFRWL
VLRLNRALDRSPRQGASFLGILDIAGFEIFQLNSFEQLCINY-TNEKLQQLFNHTMFVL-
-EQEEYQREGIPWTFLDFGLDLQPCIDLIER-------------PANPPGLLALLDEECW
FPKATDK-SFVEKVAQEQGSHPKFQRPRQLRDQADFSVLHYAGKVDYKASEWLMKNMDPL
NDNVAALLHQSTDRLTAEIWKDEHGGFQQFSFLGSFP---------PSPPGSAERCS---
-SAVS----PPGVEGIVGLEQVSSLGDG-P-P-GGRPRRGMFRTVGQLYKESLSRLMATL
SNTNPSFVRCIVPNHEKRAGKLEPR---------LVL-----DQLRCNGVLEGIRICRQG
FPNRI-------------------LF--QEFRQRYEILTPNA---IPKGFMDGKQACEKM
VSGTEP---------GSKIFFRAGVLAQLEEERDLKVTDIIVSFQAAARG--YLARRWAA
TLAQQPAECLRVMQRNCAAYLKLRHWQWWR-----------------LFTKV--KPLLQV

PF01576 // ENSGT00760000118919_8_Domain_13 (1081, 2504)

TR--QDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERTRLAEQLRAEAELCAE
A---EETRGRLAARKQ-ELELVVSEL----EAR-------VGEEEECSRQLQTEKRRLQQ
HIQVWPPACP---------LEAEEGGARQKLQLEKVTTEAKMKKFEE-DLLLLE---DQN
SKLSKERKLLEDRLSEFSSQAAE--------EEEKVKSLNKLRLKYEATIADMEDRLRKE
EKGRQELEKLKRRLDGESSE-LQEQMVEQQQRAEE-LRAQLGR--KEEELQAALARAEDE
GGARAQLLKSLREAQAALAEAQEDLEAERVARTKAEKQRRDLGEELEALRSELEDTLDST
NAQQELR---SKREQEVTALKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRG-
--KGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLESQLQ--------------
------------------EVQG------RAGDGERARAE---------------------
-AAEKLQRAQAELENVSGALNEAESKAIRLSKELSSTEAQLHDAQELLQEETRAKLALGS
RVRAMEAE-------------------------------AAGLREQLEEEAAARERAGRE
----------LQTTQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQ-----RLAE
KTETVD---RLERGRRR-----------LQQELDDA------------------TMDLE-
---QQRQLVSTLEKKQRKFDQLL----------AEEKAAVLRAVEERERAEAEGREREAR
ALSLTRALEEEQEAREE-----------------------LERQNRALRAELEALLSSKD
DVGKSVHELERACRVA--------EQAAN-DLRAQVTELED----ELTAA-EDAKLRLEV
TV---QALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEE-RKQRTLAVAARK-KL
EGELEELKAQMAS-----------A-GQGKEEAVKQL---RK------------------
-MQA-QMKELWREVEETRSS-REEIF-SQNRESEKRLKGLEAEVLRLQEELAASDRARRQ
AAQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQ
VESLTT---------ELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARAR--HKM
TIAALESKLAQAEEQLEQET----------------------------------------
----------RERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKR
QLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLR---------------
------------------------------------RGPLTFTTRTVRQVFRLEEGVASD
EE--TEEAEPGSGPS-PEPEGSPPAHPQ--

MAAVTMSVAGRKVPPRPGPVPEVAQPFLFTPRGPSAGG----GPGGSGTSPQVEWTAR

PF02736 // ENSGT00760000118919_8_Domain_0 (59, 98)

RL
VW--VPSELHGFEAAALRDEGEEEAEVELAESGRRLR

ENSGT00760000118919_8_Linker_0_1 (98, 115)

LPRDQIQRMNPPKFSKA

PF00063 // ENSGT00760000118919_8_Domain_1 (115, 993)

EDMAEL
TCLNEASVLHNLRERYYSGLIYTYSGLFCVVINPYKQLPIYTEAIVEMYRGKKRHEVPPH
VYAVTEGAYRSMLQDR-EDQSILCTGESGAGKTENTKK--V---IQ-------YLAHVAS
SPKGRKEP-------GVP-----------------------------VS----DPGELER
QLLQANPILEAFGNAKTVKNDNSS-RFGK------FIRINFDVAGYIVGANI--ETYLLE
KSRAIRQAKDERSFHI----FYQLLGGAG--EQLKADLLLEPSSRYRFLTDGPPPSPSQE
RE-LFQETLESLRVLGFTHEEITSMLRTVSAVLQFGNVVLKSERNTDQATMPDNTAAQKL
CRLLGLGVTDFSRALLTPRIK-VGRDYV----QKAQTKEQADFALEALAKATYERLFRWL
VLRLNRALDRSPRQGASFLGILDIAGFEIFQLNSFEQLCINY-TNEKLQQLFNHTMFVL-
-EQEEYQREGIPWTFLDFGLDLQPCIDLIER-------------PANPPGLLALLDEECW
FPKATDK-SFVEKVAQEQGGHPKFQLPRHLRDQADFSVLHYAGKVDYKANEWLMKNMDPL
NDNVAALLHQSADRLTAEIWKDEHGGFQQFSFLDSFP---------PSPPGCAGRFG---
-SAVS----ASGVEGIVGLEQVNSLGDG-P-P-GGRPRRGMFRTVGQLYKESLSRLMATL
SNTNPSFVRCIVPNHEKRAGKLEPR---------LVL-----DQLRCNGVLEGIRICRQG
FPNRI-------------------LF--QEFRQ---------------------------
----------------RKIFFRAGVLAQLEEERDLKVTDIIVSFQAAARG--YLARRAFQ
K-RQQQQSALRVMQRNCAAYLKLRHWQWWR-----------------LFTKV--KPLLQV

PF01576 // ENSGT00760000118919_8_Domain_13 (1081, 2504)

TR--QDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERTRLAEQLRAEAELCAE
A---EETRERLAARKQ-ELELVVSEL----ETR-------MGEEEECSRQLQTEKKRLQQ
HIQELETHL------------EAEEGARQKLQLEKVTTEAKLKKFEE-DLLLLE---DQN
AKLSKERRLLEERLAEFSSQAAE--------EEEKVKSLNKLRLKYEATIADMEDRLRKE
EKSRQELEKLKRRLDGESSE-LQEQMVEQQQRAEE-LRGQLGR--KEEELQAALARAEDE
GGARAQMLKSLREAQAALAEAQEDLDAERAARAKAEKQRRDLGEELEALRGELEDTLDST
NAQQELR---SKREQEVTELKKALEEETRVHEVAVQELRQRHGQALGELAEQLEQARRG-
--KGAWEKTRLALEAEVSELRVELSNLQTARQEGEQRRRRLESQLQ--------------
------------------EVQG------RAGDGERARVE---------------------
-AAEKLQRAQAELENVSGALSEAESRAIRLGKELSSTEAQLHDAQEVLQEETRVKLALGS
RVRALEAE-------------------------------LAGLREQLEEEAAARERAGRE
----------LQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQ-----RLAE
KTETVD---RLERGRRR-----------LQQELDDA------------------TMDLE-
---QQRQLVSTLEKKQRKFDQLL----------AEEKTAVLRAVEDRERAEAEGREREAR
ALSLTRALEEEQEAREE-----------------------LERQNRALRAELEALLSSKD
DVGKSVHELERARRVA--------EQAAS-DLRTQVTELED----ELTAA-EDAKLRLEV
TV---QALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEE-RKQRALAVAARK-KL
EAELEELKAQTAA-----------A-GQGKEEAVKQL---RK------------------
-MQA-QMKELWREVEETRSS-RDDIF-GQNRESEKRLKALEEEVLRLQEELAASDRARRQ
AQQDRDEMADEVANGNLSKAAILDEKRQLEGRLGQMEEELEEEQSNAELLNDRYRKLLLQ
VESLTT---------ELSAERSFSAKAESGRQQLERQMQELRGRLGEEDAGARAR--QKM
VIAALESKLAQAEEQLEQES----------------------------------------
----------RERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKR
QLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLR---------------
------------------------------------RGPLTFTTRTVRQVFRLEEGVASD
EE--MEEAEPGSGPPPPEPEGSPQAQPQ--

MAAVTMSVPGRKATPRPGPVPEAAQPFLFTPRGPSAGG----GPG-SATSPQVEWTAR

PF02736 // ENSGT00760000118919_8_Domain_0 (59, 98)

RL
VW--VPSELHGFEAAALRDEGEEEAEVELAESGRRLR

ENSGT00760000118919_8_Linker_0_1 (98, 115)

LPRDQIQRMNPPKFSKA

PF00063 // ENSGT00760000118919_8_Domain_1 (115, 982)

EDMAEL
TCLNEASVLHNLRERYYSGLIYTYSGLFCVVINPYKQLPIYTEAIVEMYRGKKRHEVPPH
VYAVTEGAYRSMLQDR-EDQSILCTGESGAGKTENTKK--V---IQ-------YLAHVAS
SPKGRKEPAGLPWP-APF-------------------------SLTSCIISCAWQGELER
QLLQANPILEAFGNAKTVKNDNSS-RFGK------FIRINFDVAGYIVGANI--ETYLLE
KSRAIRQAKDECSFHI----FYQLLGGAG--EQLKADLLLEPCSHYRFLTNGPSSSPGQE
RE-LFQETLESLRVLGFTHEEIISMLRMVSAVLQFGNVVLKRERNTDQATMPDNTAAQKL
CRLLGLGVTDFSRALLTPRIK-VGRDYV----QKAQTKEQADFALEALAKATYERLFRWL
VLRLNRALDRSPRQGASFLGILDIAGFEIFQLNSFEQLCINY-TNEKLQQLFNHTMFVL-
-EQEEYQREGIPWTFLDFGLDLQPCIDLIER-------------PANPPGLLALLDEECW
FPKATDK-SFVEKVAQEQGGHPKFQRPRHLRDQADFSVLHYAGKVDYKANEWLMKNMDPL
NDNVAALLHQSTDRLTAEIWKDEHGGLQQFSFLGSFP---------PSPPGSAGKCSSAV
--------SPPGVEGIVGLEQVSSLGDG-P-P-GGRPRRGMFRTVGQLYKESLSRLMATL
SNTNPSFVRCIVPNHEKRAGKLEPR---------LVL-----DQLRCNGVLEGIRICRQG
FPNRI-------------------LF--QEFRQRYEILTPNA---IPKGFMDGKQACEKM
IQALELDPNL-YRVGQSKIFFRAGVLAQLEEERDLKVTDIIVSFQAAARG--YLARRAFQ
K-RQQQQSALRVMQRNCAAYLKLRHWQWWR-----------------LFTKV--KPLLQV
TR--QDEVLQARAQELQKVQELQQQSLREVGELRGRMAELEEERTRLAEQLRAEAELCAE
A---EETRGRLAARKQ-ELELVVSEL----EAR-------VGEEEECSRQLQTEKRRLQQ
HIQELEAHL------------EAEEGARQKLQLEKVTTEAKMKKFEE-DLLLLE---DQN
SKLSKERKLLEDRLAEFSSQAAE--------EEEKVKSLNKLRLKYEATIADMEDRLRKE
EKSRQELEKLKRRLDGESSE-LQEQMVEQQQRAED-LRSQLGR--KEEELQAALARAEDE
GGARAQLLKSLREVQAALAEAQEDLEAERVARTKAEKQRRDLGEELEALRGELEDTLDST
NAQQELR---SKREQEVTELKKALEEETRIHEAAVQELRQRHGQALGELAEQLEQARRG-
--KGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLESQLQ--------------
------------------EVQG------RAGDGERARAE---------------------
-TAEKLQRAQAELENVSGALNEAESKAIRLSKELSSMDAQLHDAQVTLPALRCCRRRPGL
FILEMECH-------------------------------QLTPG---------SLTALTT
----------NHPLSPQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQ-----RLAE
KTETVD---RLERGRRR-----------LQQELDDA------------------TVDLE-
---QQRQLVSTLEKKQRKFDQLL----------AEEKAAVLRAVEERERAEAEGREREAR
ALSLTRALEEEQEAREE-----------------------LERQNRALRAELEALLSSKD
DVGKSVSRVSQPSEWS--------ECSPHPPLRPSFVHPPK----YI-------------
-----YG-----SRPGTQAALTDDGSPSR

PF01576 // ENSGT00760000118919_8_Domain_13 (2070, 2504)

LPLQLRDAEVERDEE-RKQRTLAMAARK-KL
EGELEELKAQLVS-----------A-GQGKEEAVKQL---RK------------------
-MQA-QMKELWREVEESRSS-REEIF-AQNRESDKRLKGLEAEVLRLQEELAASDRARRQ
AQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQ
VESLTS---------ELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARAR--QKM
TIAALESKLAQAEEQLEQES----------------------------------------
----------RERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKR
QLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLR---------------
------------------------------------RGPLTFTTRTVRQVFRLEEGVASD
EE--AEEAEPGSGPS-PEPEGSPSAHPQ--

MAAATLSVPGRKVAPRPSPVPEAAQPYLFTPSGPGMGG----APGGAGTSPQVEWTARRL
VW--VPSELHGFEAAALRHEGEEEAEVELAESGRRLRLPRDQIQRMNPPKFSKA

PF00063 // ENSGT00760000118919_8_Domain_1 (115, 982)

EDMAEL
TCLNEASVLHNLRERYYSGLIYTYSGLFCVVINPYKQLPIYTEAIVEMYRGKKRHEVPPH
VYAVTEGAYRSMLQDR-EDQSILCTGESGAGKTENTKK--V---IQ-------YLAHVAS
SPKGRKEPG-------VP-----------------------------VSDLPQDTGELER
QLLQANPILEAFGNAKTVKNDNSS-RFGK------FIRINFDVAGYIVGANI--ETYLLE
KSRAIRQAKDECSFHI----FYQLLGGAG--EHLKAELLLEPCSNYRFLTNGPSSSPGQE
RE-LFHETLESLKVLGFTPEEITSMLRMVSAVLQFGNIVLKRERNKDQASMPDNTAAQKL
CRLLGVGVTDFSRALLTPRIK-VGRDYV----QKAQTKEQADFALEALAKATYERLFRWL
VLRLNRALDRSPRQGASFLGILDIAGFEIFQLNSFEQLCINY-TNEKLQQLFNHTMFIL-
-EQEEYQREGIPWTFLDFGLDLQPCIDLIER-------------PANPPGLLALLDEECW
FPKATDK-SFVEKVAQEQGSHPKFQRPRNLRDQADFSVLHYAGKVDYKANEWLMKNMDPL
NDNVAALLHMSTDKLTAEIWKDEHGGFQQFSFLGSLP---------PSPPGSSGRHGSAI
SP--------TGVEGIVGLEQVSSLGDG-P-P-GGRPRRGMFRTVGQLYKESLSRLMATL
SNTNPSFVRCIVPNHEKRAGKLEPR---------LVL-----DQLRCNGVLEGIRICRQG
FPNRI-------------------LF--QEFRQRYEILTPNA---IPKGFMDGKQACEKM
IQALELDPNL-YRVGQSKIFFRAGVLAQLEEERDLKVTDIIVSFQAAARG--YLARRAFQ
K-RQQQQSALRVMQRNCAAYLKLRHWQWWR-----------------LFIKV--KPLLQV
TR--QDEVLQARAQELQKVQELQQQSAREVGELQGRLAQLEEERTRLAEQLRAEAELCAE
A---EETRGRLAARKQ-ELELVVSEL----EAR-------VGEEEECTRQLQSDKKRLQQ
HIQDLESHL------------EAEEGARQKLQLEKVTTEAKLKKFEE-DLLLLE---DQN
AKLSKERKLLEERLAEFSSQAAE--------EEEKVKSLNKLRLKYEATIADMEDRLRKE
EKGRQELEKLKRRLDGESSE-LQEQMAEQ

PF01576 // ENSGT00760000118919_8_Domain_13 (1350, 2557)

QQRGEE-LRAQLGR--KEEELQAALARVEEE
GGARAQLLKSLREAQAGLAEAQEDLEAERAARAKAEKQRRDLGEELEALRSELEDTLDST
NAQQELR---SKREQEVTELKKALEEETRVHEVAVQELRQRHGQALGELAEQLEQARRS-
--KGTWEKTRLALETEVSELRSELSSLQASRHEGEQRRRRLESQLQ--------------
------------------EVQG------RAGDGERARAE---------------------
-AAEKLQRAQAELENVSGALSEAESRAIRLSKELSSSEAQLHDAQEMLQEESRAKLALGS
KARALEAE-------------------------------VAGLREQLEEEAAARERAGRE
----------LQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALSL-----RLAE
KTEAVE---RLERGRRQ-----------LRQELDDA------------------TVDLE-
---QQRQLVSTLEKKQRKFDQLL----------AEEKAAVLRAVEERERVEAEGREREAR
TLSLTRALEEEQEAREE-----------------------LERQNRALRAEMEALLSSKD
DVGKNAHELERSRRAA--------EQTAN-DLRAQVTELED----ELTAA-EDAKLRLEV
TV---QALKAQHERDLQSRDEAGEERRRQLAKQLRDAEVERDEE-RKQRALAVAARK-KL
EAEVEDLRAQNAM-----------G-VQGKEEAVKQL---RK------------------
-MQT-QMKELWREVEETRSS-REEIF-AQNRENEKRLKALEAEVLRLQEELAASDRARRQ
IQQERDEMADEVANGSLSKTAILEEKRQLEGRLGQMEEELEEEQSNAELLNDRYRKLLLQ
VESLTT---------ELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARAR--QKM
VIAALESKLAQAEEQLEQES----------------------------------------
----------RERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKSNLRVKQLKR
QLEEAEEEASRAQSVRRRLQHELEDVTEASESMNRELNTLRNRLR---------------
------------------------------------RGPLTFTTRTVRQVFRLEEGVASE
EE--VEEAEPGAGPP-PEPEGPPVSQPQ--

MAAVTLSVPGRKASLKPGPVPEAAQPFLFAPRTPSVGG----P-G----GPQVEWTAR

PF02736 // ENSGT00760000118919_8_Domain_0 (59, 98)

RL
VW--VPSELHGFEAAALRDEGEEEAEVELAESGRRLR

ENSGT00760000118919_8_Linker_0_1 (98, 115)

LPRDQVQRMNPPKFSKA

PF00063 // ENSGT00760000118919_8_Domain_1 (115, 982)

EDMAEL
TCLNEASVLHNLRERYYSGLIYTYSGLFCVVINPYKQLPIYTEAIVEMYRGKKRHEVPPH
VYAVTEGAYRSMLQDR-EDQSILCTGESGAGKTENTKK--V---IQ-------YLAHVAS
SPKGRKEP-------GVP-----------------------------TSVSTMSYGELER
QLLQANPILEAFGNAKTVKNDNSS-RFGK------FIRINFDVAGYIVGANI--ETYLLE
KSRAIRQAKDECSFHI----FYQLLGGAG--EQLKADLLLEPCSHYRFLTNGPSSSPGQE
RE-LFQETLESLRVLGFVPEEITSMLRMVSAVLQFGNIVLKRERNTDQATMPDNTAAQKL
CRLLGLGVTDFSRALLTPRIK-VGRDYV----QKAQTKEQADFALEALAKATYERLFRWL
VLRLNRALDRSPRQGASFLGILDIAGFEIFQLNSFEQLCINY-TNEKLQQLFNHTMFVL-
-EQEEYQREGIPWTFLDFGLDLQPCIDLIER-------------PANPPGLLALLDEECW
FPKATDK-SFVEKVAQEQGGHPKFQRPRHLRDQADFSVLHYAGKVDYKANEWLMKNMDPL
NDSVAALLHQSTDRLTAEIWKD--------------------------------------
------------VEGIVGLEQVSSLGEG-P-P-GGRPRRGMFRTVGQLYKESLSRLMATL
SNTNPSFVRCIVPNHEKRAGKLEPR---------LVL-----DQLRCNGVLEGIRICRQG
FPNRI-------------------LF--QEFRQRYEILTPNA---IPKGFMDGKQACEKM
IQALELDPNL-YRVGQSKIFFRAGVLAQLEEERDLKVTDIIVSFQAAARG--YLARRAFQ
R-RQQQQSALRVMQRNCAAYLKLRNWQWWR-----------------LFIKV--KPLLQV

PF01576 // ENSGT00760000118919_8_Domain_13 (1081, 2504)

TR--QDEVLQARAQELQKVQELHQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCSE
A---EETRVRLAARKQ-ELEAVVSEL----EAR-------VGEEEECSRQLQSEKKRLQL
HIQELETHL------------EAEEGARQKLQLEKVTTEAKMKKFEE-DLLLLE---DQN
AKLSKERRLLEERLAEFSSQAAE--------EEEKVKSLNKLRLKYETTIADMEDRLRKE
EKGRQELEKLKRQLDGESSE-LQEQMAEQQQRAEE-LRAQLGR--KEDELQAALARAEEE
GGARAQLLKSLREAQAGLAEAQEDLEAERAARAKAEKQRRDLGEELEALRSELEDTLDST
NAQQELR---SKREQEVTELKKALEEEARTHEVAVQELRQRHGQALGELAEQLEQARRS-
--KGVWEKSRLALEAEVSELRSELNSLQTARQEGEQKRRRLESQLQ--------------
------------------EVQG------RASDKEQARAE---------------------
-AAEKLQRAQAELESISAALSEAESKAIRLGKELSSTESQLHDTQEQLQEETRAKLALGS
RIRAVEAE-------------------------------AAGLREQLEEEAAARERAGRE
----------LQSAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALAQ-----RLAE
KTEAVE---RLERGRRR-----------LQQELDDV------------------TVDLE-
---QQRQLVSTLEKKQRKFDQLL----------AEEKAAVLRAVEDRERVEAEGREREAR
ALSLTRALEEEQEAREE-----------------------LERQNRALRAELEALLSSKD
DVGKNVHELERARRVA--------EQAAN-DLRAQVTELED----ELTAA-EDAKLRLEV
TV---QALKAQHERDLQGHDEAGEERRRQLAKQLRDAEVERDEE-RKQRALAVSARK-KL
EGELEELKAQIAS-----------A-GQGKEEAVKQL---RK------------------
-MQA-QMKELWREVEETRSS-REEIF-AQNKESEKRLKGLEAEVLRLQEELAASDRARRQ
AQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQMEEELEEEQNNAELLNDRYRKLLLQ
VESLTT---------ELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARAR--QKM
LIAALESKLAQAEEQLEQES----------------------------------------
----------RERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKR
QLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLR---------------
------------------------------------RGPLTFTTRTVRQVFRLEEGVASD
EE--AEEAPPESAPP-QEPEAPPLITPQ--

MAAVTMSVPGRKAPPRPGPVPEAAQPFLFTPRGPSAGG----GPG-SGTSPQVEWTAR

PF02736 // ENSGT00760000118919_8_Domain_0 (59, 98)

RL
VW--VPSELHGFEAAALRDEGEEEAEVELAESGRRLR

ENSGT00760000118919_8_Linker_0_1 (98, 115)

LPRDQIQRMNPPKFSKA

PF00063 // ENSGT00760000118919_8_Domain_1 (115, 982)

EDMAEL
TCLNEASVLHNLRERYYSGLIYTYSGLFCVVINPYKQLPIYTEAIVEMYRGKKRHEVPPH
VYAVTEGAYRSMLQDR-EDQSILCTGESGAGKTENTKK--V---IQ-------YLAHVAS
SPKGRKEP-------GVP-----------------------------ASISTVSYGELER
QLLQANPILEAFGNAKTVKNDNSS-RFGK------FIRINFDVAGYIVGANI--ETYLLE
KSRAIRQAKDECSFHI----FYQLLGGAG--EQLKADLLLEPCSHYRFLTNGPSSSPGQE
RE-LFQETLESLRVLGFTHEEIISMLRMVSAVLQFGNIALKRERNTDQATMPDNTAAQKL
CRLLGLGVTDFSRALLTPRIK-VGRDYV----QKAQTKEQADFALEALAKATYERLFRWL
VLRLNRALDRSPRQGASFLGILDIAGFEIFQLNSFEQLCINY-TNEKLQQLFNHTMFVL-
-EQEEYQREGIPWTFLDFGLDLQPCIDLIER-------------PANPPGLLALLDEECW
FPKATDK-SFVEKVAQEQGGHPKFQRPRHLRDQADFSVLHYAGKVDYKANEWLMKNMDPL
NDNVAALLHQSTDRLTAEIWKDEHGGFQQFSFLGSFPPSPPGSAERCSSASSPPGV----
-------------EGIVGLEQVSSLGDG-P-P-GGRPRRGMFRTVGQLYKESLSRLMATL
SNTNPSFVRCIVPNHEKRAGKLEPR---------LVL-----DQLRCNGVLEGIRICRQG
FPNRI-------------------LF--QEFRQRYEILTPNA---IPKGFMDGKQACEKM
IQALELDPNL-YRVGQSKIFFRAGVLAQLEEERDLKVTDIIVSFQAAARG--YLARRAFQ
K-RQQQQSALRVMQRNCAAYLKLRHWQWWR-----------------LFTKV--KPLLQV

PF01576 // ENSGT00760000118919_8_Domain_13 (1081, 2504)

TR--QDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAE
A---EETRGRLAARKQ-ELELVVSEL----EAR-------VGEEEECSRQMQTEKKRLQQ
HIQELEAHL------------EAEEGARQKLQLEKVTTEAKMKKFEE-DLLLLE---DQN
SKLSKERKLLEDRLAEFSSQAAE--------EEEKVKSLNKLRLKYEATIADMEDRLRKE
EKGRQELEKLKRRLDGESSE-LQEQMVEQQQRAEE-LRAQLGR--KEEELQAALARAEDE
GGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDST
NAQQELR---SKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRG-
--KGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQ--------------
------------------EVQG------RAGDGERARAE---------------------
-AAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGS
RVRAMEAE-------------------------------AAGLREQLEEEAAARERAGRE
----------LQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQ-----RLAE
KTETVD---RLERGRRR-----------LQQELDDA------------------TMDLE-
---QQRQLVSTLEKKQRKFDQLL----------AEEKAAVLRAVEERERAEAEGREREAR
ALSLTRALEEEQEAREE-----------------------LERQNRALRAELEALLSSKD
DVGKSVHELERACRVA--------EQAAN-DLRAQVTELED----ELTAA-EDAKLRLEV
TV---QALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEE-RKQRTLAVAARK-KL
EGELEELKAQMAS-----------A-GQGKEEAVKQL---RK------------------
-MQA-QMKELWREVEETRTS-REEIF-SQNRESEKRLKGLEAEVLRLQEELAASDRARRQ
AQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQ
VESLTT---------ELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARAR--HKM
TIAALESKLAQAEEQLEQET----------------------------------------
----------RERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKR
QLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLR---------------
------------------------------------RGPLTFTTRTVRQVFRLEEGVASD
EE--AEEAQPGSGPS-PEPEGSPPAHPQ--

MAAMTLSMPGRKVAPKPGPVPEAAQPYLFTPHTPSMGG----PG-----GPQVEWTAR

PF02736 // ENSGT00760000118919_8_Domain_0 (59, 98)

RL
VW--VPSELHGFEAAALRDEGEEEAEVELAESGRRLR

ENSGT00760000118919_8_Linker_0_1 (98, 115)

LPRDQIQRMNPPKFSKA

PF00063 // ENSGT00760000118919_8_Domain_1 (115, 982)

EDMAEL
TCLNEASVLHNLRERYYSGLIYTYSGLFCVVINPYKQLPIYTEAIVEMYRGKKRHEVPPH
VYAVTEGAYRSMLQG---------DGESGAGKTENTKK--V---IQ-------YLAHVAS
SPKGRKEP-------GVP-------------------------------------GELER
QLLQANPILEAFGNAKTVKNDNSS-RFGK------FIRINFDVTGYIVGANI--ETYLLE
KSRAIRQAKDECSFHI----FYQLLGGAG--EQLKADLLLEPCSHYRFLTNGPSSTPGQE
RE-LFHETLESLRVLGFLPEEITAILRTVSAVLQFGNIVLKKERNTDQATMPDNTAAQKL
CRLLGLGVTDFSRALLTPRIK-VGRDYV----QKAQTKEQADFALEALAKATYERLFRWL
VLRLNRALDRSPRQGASFLGILDIAGFEIFQLNSFEQLCINY-TNEKLQQLFNHTMFVL-
-EQEEYQREGIPWTFLDFGLDLQPCIDLIER-------------PANPPGLLALLDEECW
FPKATDK-SFVEKVAQEQGGHPKFQRPRHLRDQADFSVLHYAGKVDYKANEWLMKNMDPL
NDSVAALLHQSTDRLTAEIWKDEQGGIRHFSSLDCSPLP---------PPGPAGRSDLDP
SVSLS----PHTVEGIVGLEQVSSLGDG-P-P-GGRPRRGMFRTVGQLYKESLSRLMATL
SNTNPSFVRCIVPNHEKRAGKLEPK---------LVL-----DQLRCNGVLEGIRICRQG
FPNRI-------------------LF--QEFRQRYEILTPNA---IPKGFMDGKQACEKM
IQALELDPNL-YRVGQSKIFFRAGVLAQLEEERDLKVTDIIVSFQAAARG--YLARRAFQ
R-RQQQQSALRVMQRNCAAYLKLRNWQWWR-----------------LFIKV--KPLLQV

PF01576 // ENSGT00760000118919_8_Domain_13 (1081, 2504)

TR--QDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERLRLAEQLRAEAELCSE
A---EETRARLAARKQ-ELELVVSEL----EAR-------VGEEEECSRQLQGEKKRLQQ
HIQELETHL------------EAEEGARQKLQLEKVTTEAKMKKFQE-DLLILE---DQN
AKLSKERKLLEERLAEFSSQAAE--------EEEKVKSLNKLRLKYEATIADMEDRLRKE
ERGRQELEKTKRRLDGESSE-LQEQMAEQQQRAEE-LRVQLGR--KEDELQAALARAEEE
GGARAQLLKSLREAQAGLAEAQEDLEAERVARAKAEKQRRDLGEELEALRGELEDTLDST
NAQQELR---SKREQEVTELKKALEEEARAHEVTVQELRQRHGQALGELAEQLEQARRG-
--KGVWEKARLALEAEVSELRTELSSLQTSRQEGEQKRRRLESQLQ--------------
------------------EVQG------RAGDGERARAE---------------------
-AAEKLQRAQAELESVSTALSEAESKSIRLSKELSSTESQLHDTQELLQEETRAKLALGS
RVRAVEAE-------------------------------AAGLREQMEEEAAARERAARE
----------LQSAQAQLSEWRRRQEEEAGALEAGEEARRKVAREAEALTQ-----RLTE
KTEVVE---RLERGRRR-----------LQQELDDA------------------VVDLE-
---QQRQLVSTLEKKQRKFDQLL----------AEEKAAVLRAVEERERVEAEGREREAR
ALSLTRALEEEQEAREE-----------------------LERQNRALRAELEALLSSKD
DVGKSVHELERARRVA--------EQAAS-DLRTQVTELED----ELTAA-EDAKLRLEV
TV---QALKAQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEE-RKQRALAVAARK-KL
EAELEELKAQTSA-----------A-GQGKEEAVKQL---RK------------------
-MQV-QMKELWREVEETRTS-REEIF-SLNKESEKRLKGLEEEVLRLQEELAASDRARRQ
AQQDREEMADEVANGNLSKAAILEEKRQLEGRLGQMEEELEEEQSNAELLNDRYRKLLLQ
VESLTT---------ELSAERSFSAKAESGRQQLEKQIQELRGRLGEEDAGARAR--QKM
VIAALESKLAQAEEQLEQES----------------------------------------
----------RSRMLSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRLKQLKR
QLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLR---------------
------------------------------------RGPLTFTTRTVRQVFRLEEGVASD
EE--GEEAQSGSAPT-PEPEAPPPATSQ--

MAAVTLSVPGRKAAPRPSPVPEAAQPYLFTPRGPGVGG----GPGGAGTSPQVEWTAR

PF02736 // ENSGT00760000118919_8_Domain_0 (59, 98)

RL
VW--VPSELHGFEAAALRDEGEEEAEVELAESGRRLR

ENSGT00760000118919_8_Linker_0_1 (98, 115)

LPRDQIQRMNPPKFSKA

PF00063 // ENSGT00760000118919_8_Domain_1 (115, 982)

EDMADL
TCLNEASVLHNLRERYYSGLIYTYSGLFCVVINPYKQLPIYTEAIVEMYRGKKRHEVPPH
VYAVTEGAYRSMLQDR-EDQSILCTGESGAGKTENTKK--V---IQ-------YLAHVAS
SPKGRKEPGVP--------------------------------------------GELER
QLLQANPILEAFGNAKTVKNDNSS-RFGK------FIRINFDVAGYIVGANI--ETYLLE
KSRAIRQAKDECSFHI----FYQLLGGAG--EQLKADLLLEPCSHYRFLTNGSSSPPGQE
RE-LFHETLESLRVLGFTPEEITSMLRMVSAVLQFGNIVLKRERNNDQASMPDNTEFRRA
MGVGGWEVGQSEPMLEVSRIQLLGRGLCLSPGPHMRPAPQADFALEALAKATYERLFRWL
VLRLNRALDRSPRQGASFLGILDIAGFEIFQLNSFEQLCINY-TNEKLQQLFNHTMFVL-
-EQEEYQREGIPWTFLDFGLDLQPCIDLIERARPPPRPPPGDTPPANPPGLLALLDEECW
FPKATDK-SFVEKVAQEQGGHPKFQRPRNLRDQADFSVLHYAGKVDYKANEWLMKNMDPL
NDNVAALLHQSTDRLTAEIWKDVHLKLTPDPLLSLHL-----------------------
-------FPLPVVEGIVGLEQVSSLGDG-P-P-GGRPRRGMFRTVGQLYKESLSRLMATL
SNTNPSFVRCIIPNHEKRVSDWPGDGAGAL-FPWGCFDGETSLMLSCNGY-DTLPCCHRH
FFTNA-------------------IE--RDRTENTGILTPNA---IPKGFMDGKQACEKM
IQALELDPNL-YRVGQSKIFFRAGVLAQLEEERDLKVTDIIVSFQAAARG--YLARRAFQ
K-RQQQQSALRVMQRNCAAYLKLRHWQWWR-----------------LFIKV--KPLLQV
TR--QDEVLQARAQELQKVQELQQQSAREVGELQGRLAQLEEERTRLAEQLRAEAELCAE
A---EETRGRLAARKQ-ELELVVSEL----EAR-------VGEEEECSRQLQTEKKRLQQ
HIQELENHL------------EAEEGARQKLQLEKVTTEAKLKKFEE-DLVLLE---DQN
AKLSKERRLLEERLAEFSSQAAE--------EEEKIKSLNKLRLKYEATIADMEDRLRKE
EKGRQELEKLKRRLDGESSE-LQEQMAEQQQRAEE-LRAQLGR--KEVELQAALARAEEE
GGARAQLLKSLREAQAGLAEAQEDLETERAARAKAEKQRRDLGEELEALRSELEDTLDST
NAQQELR---SKREQEVTELKKALEEETRVHEVAVQELRQRHGQALGELAEQLEQARRS-
--KGTWEKTRMALEAEVSELRAELSSLQTSRQEGEQRRRRLESQLQ--------------
------------------EVQG------RAGDGERARAE---------------------
-ATEKLQRAQAELENVSGALSEAESRAIRLSKELSSTEAQLHDAQEAV------------
----------------------------------------------------ARERAGRE
----------LQTAQAQNSPPQPSSEAEEPRA--ASLFPLQASVPSMLLSS----KSLEN
RTPIHPDLCLLSQNNCW-----------LKYIVKND------------------VPAL--
------CYDHPRRKKHPFVCW

PF01576 // ENSGT00760000118919_8_Domain_13 (1882, 2504)

LL----------AEEKAAVLRAVEERERVEAEGREREAR
TLSLTRALEEEQEAREE-----------------------LERQNRALRAEMEALLSSKD
DVGKNVHEMERARRVA--------EQTVS-DLRTQVTELED----ELTAA-EDAKLRLEV
TV---QALKAQHERDLQGRDEVGEERRRQLAKQLRDAEVEREEE-RKQRTQAVAARK-KL
EVELEDLKAQNAA-----------A-AQGKEDAVKQL---RK------------------
-MQA-QMKELWREVEESRTS-REEIF-AQNRESEKRLKALEAEVLRLQEELAASDRARRQ
VQQERDEMADEVANGSLSKAAILEEKRQLEGRLGQMEEELEEEQSNAELLGDRYRKLLLQ
VDSLTT---------ELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARAR--QKM
IIAALESKLSQAEEQLEQES----------------------------------------
----------RERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQVEKGNLRVKQLKR
QLEEAEEEASRAQAVRRRLQHELEDVTESSEAMNRELNALRNRLR---------------
------------------------------------RGPLTLTTRKVRQVFRLEEGVPLE
EE--MEEEEAGSGPPPPEPDEPPAAAPQPQ

MAAVTLSVPGRKAPPRPGPVPEAAQPFLFAPRSGGSGG----P--TAGGGPQVEWTAR

PF02736 // ENSGT00760000118919_8_Domain_0 (59, 98)

RL
VW--VPSELHGFEAAALRDEGEEEAEVELAESGRRLR

ENSGT00760000118919_8_Linker_0_1 (98, 115)

LPRDQIQRMNPPKFSKA

PF00063 // ENSGT00760000118919_8_Domain_1 (115, 982)

EDMAEL
TCLNEASVLHNLRERYYSGLIYTYSGLFCVVINPYKQLPIYTEAIVEMYRGKKRHEVPPH
VYAVTEGAYRSMLQG---------DGESGAGKTENTKK--V---IQ-------YLAHVAS
SPKGRKEP-------GVP-------------------------------------GELER
QLLQANPILEAFGNAKTVKNDNSS-RFGK------FIRINFDVAGYIVGANI--ETYLLE
KSRAIRQAKDECSFHI----FYQLLGGAS--EQLKADLLLEPCSQYRFLTNGPASSPGQE
RE-LFQETLASLRVLGFTPEEITSMLRTVSAVLQFGNVVLKRERNTDQATMPDNTAAQKL
CRLLGLGVTDFSRALLTPRIK-VGRDFV----QKAQTKEQADFALEALAKATYERLFRWL
VLRLNRALDRSPRQGASFLGILDIAGFEIFQLNSFEQLCINY-TNEKLQQLFNHTMFVL-
-EQEEYQREGIAWTFLDFGLDLQPCIDLIER-------------PANPPGLLALLDEECW
FPKATDK-SFVEKVAQEQGGHPKFQRPRHLRDQADFSVLHYAGKVDYKANEWLMKNMDPL
NDSVASLLHQSTDRLTAEIWKDEHGGLQQFASLGSFPPSS---------PGSPGRCSSAP
SPPGG----GCVLEGIVGLEQVSSLGDG-P-P-GGRPRRGMFRTVGQLYKESLSRLMATL
SNTNPSFVRCIVPNHEKRAGKLEPR---------LVL-----DQLRCNGVLEGIRICRQG
FPNRI-------------------LF--QEFRQRYEILTPNA---IPKGFMDGKQACEKM
IQALELDPNL-YRVGQSKIFFRAGVLAQLEEERDLKVTDIIVSFQAAARG--YLARRAFQ
R-RQQQQSALRVMQRNCAAYLKLRNWQWWR-----------------LFIKV--KPLLQV

PF01576 // ENSGT00760000118919_8_Domain_13 (1081, 2504)

TR--QDEVLQARAQELQKVQELQQQSAREVGELQIRVTQLEEERTRLAEQLRAEAELCAE
A---EETRGRLAARKQ-ELELVVTEL----EAR-------VGEEEECSRQLQAEKKRLQQ
HIQELETHL------------EAEEGARQKLQLEKVTTEAKMKKFEE-DLLALE---DQN
TKLSKERRLLEERLAESSSQAAE--------EEEKIKSLNKLRLKYEATIADMEDRLRKE
EKGRQELEKLKRRLDGESSE-LQEQMLEQQQRAEE-LRVQLGR--KEEELQAALLKAEEE
SGARTQLVKSLREVQAGLAEAQEDLEAERAARAKAEKQRRDLGEELEALRGELEDTLDST
NAQQELR---SKREQEVTELKKALEEEARVHEVAIQELRQRHGQALGELAEQLEQARRG-
--KGAWEKTRLTLETEVSELRTELSSLQTVRQESEQKRRRLESQLQ--------------
------------------EMQG------RAGDGERARAE---------------------
-AAEKLQRAQAELENVSGALSEAESKAIRLAKELSSTEAQLHDAQELLQEETRAKLALGS
RVRAMEAE-------------------------------AAGLREQLEEEAAARERAARE
----------LQSAQAQLSEWRKRQEEEAGALEAGEEARRRAAREAETLAQ-----RLAE
KTEAAE---RLERGRRR-----------LQQELDDA------------------IMDLE-
---QQRQLVSSLEKKQRKFDQLL----------AEEKAAVLRAVEDRERVEAEGREREAR
ALSLTRALEEEQEAREE-----------------------LERQNRALRAELEALLGSKD
DVGKNVHELERTCRVA--------EQAAS-DLRTQVTELED----ELTAA-EDAKLRLEV
TV---QALRAQHERDLQGRDEASEERRRHLAKQLRDAEVERDEE-RKQRALAVAARK-KL
EAELEELKAQTAA-----------A-GQGKEEAVKQL---RK------------------
-MQA-QMKELWREVEETRSS-REEIF-AQNRESEKRLKGLEAEVLRLQEELAASDRARRQ
AQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQMEEELEEEQSNAELLGDRYRKLLLQ
VESLTT---------ELSAERSFSAKAESGRQQLERQMQELRGRLGEEDAGARAR--QKM
VIAALESKLAQAEEQLEQES----------------------------------------
----------RSRILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKR
QLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLR---------------
------------------------------------RGPLTFTTRTVRQVFRLEEGVASD
EE--AEGAEPGQEAPPQAQEAPPQ------

MAAVTLSVPGRKAAPRPGPGAGAPQPYLFAPSGPGVGG----SPGGAGTSPQVEWTA

PF02736 // ENSGT00760000118919_8_Domain_0 (58, 102)

RRL
VW--VPSELHGFEAAALRDEDEEEAEVELAESGRRLRLPRD

ENSGT00760000118919_8_Linker_0_1 (102, 114)

QIQRMNPPKFSK

PF00063 // ENSGT00760000118919_8_Domain_1 (114, 982)

AEDMAEL
TCLNEASVLHNLRERYYSGLIYTYSGLFCVVINPYKQLPIYTEAIVEMYRGKKRHEVPPH
VYAVTEGAYRSMLQDR-EDQSILCTGESGAGKTENTKK--V---IQ-------YLAHVAS
SPKGRKEPG-------VP-----------------------------VSALSQDMGELER
QLLQANPILEAFGNAKTVKNDNSS-RFGK------FIRINFDVAGYIVGANI--ETYLLE
KSRAIRQAKDECSFHI----FYQLLGGAG--EQLRAELLLEPCSHYRFLTNGPSSSPSQE
RE-LFHETLESLRVLGFTPDEITSMLRIVSAVLQFGNIVLKRERNNDQASMPDNTAAQKL
CRLLGLGVTDFSRALLTPRIK-VGRDYV----QKAQTKEQADFALEALAKATYERLFRWL
VLRLNRALDRSPRQGASFLGILDIAGFEIFQLNSFEQLCINY-TNEKLQQLFNHTMFIL-
-EQEEYQREGIPWTFLDFGLDLQPCIDLIER-------------PANPPGLLALLDEECW
FPKATDK-SFVEKVAQEQGGHPKFQRPRNLRDQADFSVLHYAGKVDYKANEWLMKNMDPL
NDSVAALLHMSTDKLTAEIWKDEHGGFQQFSFLGSFP---------PSPPGSSGRRGSAI
SP--------SGVEGIVGLEQVSSLGDG-P-P-GGRPRRGMFRTVGQLYKESLSRLMATL
SNTNPSFVRCIVPNHEKRAGKLEPR---------LVL-----DQLRCNGVLEGIRICRQG
FPNRI-------------------LF--QEFRQRYEILTPNA---IPKGFMDGKQACEKM
IQALELDPNL-YRVGQSKIFF

ENSGT00760000118919_8_Linker_1_12 (982, 998)

RAGVLAQLEEERDLKV

PF00612 // ENSGT00760000118919_8_Domain_12 (998, 1020)

TDIIVSFQAAARG--YLARRAFQ
K-RQQQQSALRVMQRNCAAYLKLRHWQWWR-----------------LFIKV--KPLLQV
TR--QDEVLQARAQELQKVQELQQQSAREVGELQGRLAQLEEERTRLAEQLRAEAELCAE
A---EETRGRLAARKQ-ELELVVAEL----EAR-------VGEEEECSRQLQSDKKRLQQ
HIQELESHL------------EAEEGARQKLQLEKVTTEAKLKKFEE-DLLLLE---DQN
AKLSKERKLLEERLAEFSSQAAE--------EEEKVKSLNKLRLKYEATIADMEDRLRKE
EKGRQELEKLKRRLDGESSE-LQEQMA

PF01576 // ENSGT00760000118919_8_Domain_13 (1348, 2557)

EQQQRREE-LRAQLGR--KEEELQAALARVEEE
DGARALLLKSLREAQAGLAEAQEDLEAERVARAKAEKQRRDLGEELEALRSELEDTLDST
NTQQELR---SKREQEVTELKKALEEETRVHEVAVQELRQRHGQALGELVEQLEQARRS-
--KGTWEKTRLALETEVSELRSELSSLQASRHEGEQRRRRLESQLQ--------------
------------------EVQG------RAGDGERARAE---------------------
-ATEKLQRVQAELENVSGALSEAESRAIRLSKELSSSEAQLHDAQEMLQEESRAKLALGS
RARALEAE-------------------------------MVGLREQLEEEAAARERAGHE
----------LQTTQAQLSEWRRRQEEEAGALEAGEEARRRAAREVEALTL-----RLAE
KTEA------XERGRRQ-----------LGQELEDA------------------IMDLE-
---QQRQLVSTLEKKQRKFDQLL----------ADEKAAVLRAVEERERVEAEGREREAR
ALSLTRALEEEQEAREE-----------------------LERQNRALRAEMETLLSSKD
DAGKTAHEQERSRRAA--------EQIAS-DLRAQVTELED----ELTAA-EDAKLRLEV
TL---QALKAQHERDLQGRDEAGEERRRQLAKQLRDAEVERE-E-RKQRALAVAARK-KL
EAELEDLRAQNAA-----------A-AQGKEEAGKQL---RK------------------
-MQA-QMKELWREVEESRSS-REEIF-AQNRESEKRLKALETEVLRLQEELAASDRARRQ
IQQERDEMADELANGSLSKAAVLEEKRQLEGRLGQMEEELEEEQSNSELLNDRYRKLLLQ
VESLTT---------ELSAERSFSAKAESGRQQLERQMQELRGRLGEEDAGVRAR--QKM
VIAALESKLAQAEEQLEQES----------------------------------------
----------RERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKSNLRVKQLKR
QLEEAEEEASRAQSVRRRLQHELEDVTEASESMNRELNTLRNRLR---------------
------------------------------------RGPLTFTTRTVRQVFRLEEGVVSE
EE--AEEAEPGAGPPPPEPHGPPASQPQ--

MAAVTMSVPGRKAPPRPGPVPEAAQPFLFTPRGPSAGG----GPG-SGTSPQVEWTAR

PF02736 // ENSGT00760000118919_8_Domain_0 (59, 98)

RL
VW--VPSELHGFEAAALRDEGEEEAEVELAESGRRLR

ENSGT00760000118919_8_Linker_0_1 (98, 115)

LPRDQIQRMNPPKFSKA

PF00063 // ENSGT00760000118919_8_Domain_1 (115, 982)

EDMAEL
TCLNEASVLHNLRERYYSGLIYTYSGLFCVVINPYKQLPIYTEAIVEMYRGKKRHEVPPH
VYAVTEGAYRSMLQDR-EDQSILCTGESGAGKTENTKK--V---IQ-------YLAHVAS
SPKGRKEP-------GVP-------------------------------------GELER
QLLQANPILEAFGNAKTVKNDNSS-RFGK------FIRINFDVAGYIVGANI--ETYLLE
KSRAIRQAKDECSFHI----FYQLLGGAG--EQLKADLLLEPCSQYRFLTNGPSSSPGQE
RE-LFQETLESLRVLGFTHEEIISMLRMVSAVLQFGNIALKRERNTDQATMPDNTAAQKL
CRLLGLGVTDFSRALLTPRIK-VGRDYV----QKAQTKEQADFALEALAKATYERLFRWL
VLRLNRALDRSPRQGASFLGILDIAGFEIFQLNSFEQLCINY-TNEKLQQLFNHTMFVL-
-EQEEYQREGIPWTFLDFGLDLQPCIDLIER-------------PANPPGLLALLDEECW
FPKATDK-SFVEKVAQEQGGHPKFQRPRQLRDQADFSVLHYAGKVDYKANEWLMKNMDPL
NDNVAALLHQSTDRLTAEIWKDEHGGFQQFSFLGSFPPSPPGSAERCSSAVSPPGV----
-------------EGIVGLEQVSSLGDG-P-P-GGRPRRGMFRTVGQLYKESLSRLMATL
SNTNPSFVRCIVPNHEKRAGKLEPR---------LVL-----DQLRCNGVLEGIRICRQG
FPNRI-------------------LF--QEFRQRYEILTPNA---IPKGFMDGKQACEKM
IQALELDPNL-YRVGQSKIFFRAGVLAQLEEERDLKVTDIIVSFQAAARG--YLARRAFQ
K-RQQQQSALRVMQRNCAAYLKLRHWQWWR-----------------LFTKV--KPLLQV

PF01576 // ENSGT00760000118919_8_Domain_13 (1081, 2504)

TR--QDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERTRLAEQLRAEAELCAE
A---EETRGRLAARKQ-ELELVVSEL----EAR-------VGEEEECSRQLQTEKKRLQQ
HIQELEAHL------------EAEEGARQKLQLEKVTTEAKMKKFEE-DLLLLE---DQN
SKLSKERKLLEDRLSEFSSQAAE--------EEEKVKSLNKLRLKYEATIADMEDRLRKE
EKGRQELEKLKRRLDGESSE-LQEQMVEQQQRAEE-LRAQLGR--KEEELQAALARAEDE
GGARAQLLKSLREAQAALAEAQEDLEAERVARTKAEKQRRDLGEELEALRSELEDTLDST
NAQQELR---SKREQEVTALKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRG-
--KGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLESQLQ--------------
------------------EVQG------RAGDGERARAE---------------------
-AAEKLQRAQAELENVSGALNEAESKAIRLSKELSSTEAQLHDAQELLQEETRAKLALGS
RVRAMEAE-------------------------------AAGLREQLEEEAAARERAGRE
----------LQTTQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQ-----RLAE
KTETVD---RLERGRRR-----------LQQELDDA------------------TMDLE-
---QQRQLVSTLEKKQRKFDQLL----------AEEKAAVLRAVEERERAEAEGREREAR
ALSLTRALEEEQEAREE-----------------------LERQNRALRAELEALLSSKD
DVGKSVHELERACRVA--------EQAAN-DLRAQVTELED----ELTAA-EDAKLRLEV
TV---QALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEE-RKQRTLAVAARK-KL
EGELEELKAQMAS-----------A-GQGKEEAVKQL---RK------------------
-MQA-QMKELWREVEETRSS-REEIF-SQNRESEKRLKGLEAEVLRLQEELAASDRARRQ
AAQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQ
VESLTT---------ELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARAR--HKM
TIAALESKLAQAEEQLEQET----------------------------------------
----------RERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKR
QLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLR---------------
------------------------------------RGPLTFTTRTVRQVFRLEEGVASD
EE--TEEAEPGSGPS-PEPEGSPPAHPQ--

MAAVTMSVPDRKAPPRPGPVPEAAQSYLFTARGSGGGS----GP-GLGASPQVEWTA

PF02736 // ENSGT00760000118919_8_Domain_0 (58, 102)

RRL
VW--VPSELHGFEAAALRDEGEEEAEVELAESGRRLRLPRD

ENSGT00760000118919_8_Linker_0_1 (102, 114)

QIQRMNPPKFSK

PF00063 // ENSGT00760000118919_8_Domain_1 (114, 938)

AEDMAEL
TCLNEASVLHNLRERYYSGLIYTYSGLFCVVINPYKQLPIYTEAIIDMYRGKKRHEVPPH
VYAVTEGAYRSMLQXXXXXXXXXXXXXXXXXXXXXXXXXXX---XX-------XXXXXXX
XXX-----XXXXXXXXXX----------------------------XX-----XXXXX-X
-XXXX-XXXXXXXXXXXXXXX-XX-XX--------XXXXXXXX--XXXX-XX--XXXXXX
------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXDLLLEPCSNYRFLTNGPSSSPGQE
RE-LFQETLESLRVLGFTHEEIIXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXX-XXXXXX----XXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXLGILDIAGFEIFQLNSFEQLCINY-TNEKLQQLFNHTMFVL-
-EQEEYQREGIPWTFLDFGLDLQPCIDLIER-------------PANPPGLLALLDEECW
FPKATDK-SFVEKVAQEQGGHPKFQRPRQLRDHADFSVLHYAGKVDYKANEWLMKNMDPL
NDSVAALLHQSTDRLTAEIWKDGPGGFQQFSLLAAFQPPQPFSGSAAE------------
--RHGPATSSSGVEGIVGLEQVSSLGDG-P-P-GGRPRRGMFRTVGQLYKESLSRLMATL
SNTNPSFVRCIVPNHEKRAGKLEPR---------LVL-----DQLRCNGVLEGIRICXXX
XXXXX-------------------XX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXX--XXXX-XX---XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXAFQ
K-RQQQQSALKVMQRNCAAYLKLRHWQWWR-----------------LFIKV--KPLLQV
TR--QDEVLQARVQELQKVQELQQQSARQLGELQDRLVQLEEERSRLSEQLRAEAELCAE
A---EETRGHLAARKQ-ELELVVSEL----EAR-------VGEEEECSRQLQMEKKRLQQ
HIQELETHL------------EAEEGVWQKLQLEKVTTEARLKKFEE-SLVLLE---DQN
AKLSKERKLLEERLAEFSSQAAE--------EEEKVKSLNKLRLKYEATITDMEXXXXXX
XXXXXXXXXXXXXXXXXXXX-XXXXXX--XXXXXX-XXXXXXXXXXXXXXXXXXXX

PF01576 // ENSGT00760000118919_8_Domain_15 (1377, 1447)

AEEE
GGARAQLLKSLREAQAGMAEAQEDLEAERVARAKAEKQRRDLGEELEALRGELEDTLDST
NVQLEL

ENSGT00760000118919_8_Linker_15_16 (1447, 1503)

RXXXXXXXXXXXXXXXXXXXXXXX------XXXXXXXXXXXXXXXXXXXXXXXX
XG

PF01576 // ENSGT00760000118919_8_Domain_16 (1503, 1628)

KGAWDKTRLVLEAEVAELRAELGNLQAARQEGEQRRRRLESQLQ--------------
------------------EVQG------RAGDGERARAE---------------------
-TAEKLQRAQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX----XXX-
---XXXXX---------------------------------------------XXXXXXX
----------XXXXXXXXXXXXXXXXXXXX----X-------------XXX-----XXX-
-XX-XX---X--XXXXX-----------XXXXXXXX------------------XXXXX-
------XXXXXXXXXXXXXXXXX----------XX-XXXXXXXX--------------XX
XXXXXXX---XXXXXXX-----------------------XXXXXXXXXXXXXXXXXXXS
SKNM

PF01576 // ENSGT00760000118919_8_Domain_13 (1985, 2280)

SVHELERARRVA--------EQAAS-DLRTQVTELED----ELTAA-EDAKLRLEV
TV---QALKAQHERDLQGRDEAGEERRRQLAKQLRDAELERDEE-RKQRAMAVAARK-KL
EAELEELKAQTAA-----------A-GQGREEAGKQL---RK------------------
-MQA-QMKELWREVEDYRTS-REEIF-AQNKESEKRLKGLEAEVLRLQEELAASDRARRH
AQQERDEMADEVASGNLSKAALLEEKRQLEVRLGQMEEELDEEQSNAELVNDRYHKLLLQ
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------

MAAVTVSVPGRKAPPRPGPVPEAAQPFLFAPXE---------------------------
------------------------AEVELAESGRRLRLPRDQIQRMNPPKFSKA

PF00063 // ENSGT00760000118919_8_Domain_1 (115, 982)

EDMAEL
TCLNEASVLHNLRERYYSGLIYTYSGLFCVVINPYKQLPIYTEAIVEMYRGKKRHEVPPH
VYAVTEGAYRSMLQDR-EDQSILCTGESGAGKTENTKK--V---IQ-------YLAHVAS
SPKGRKEPGVPASAGAV------------------------------------SYGELEQ
QLLQANPVLEAFGNAKTVKNDNSS-RFGK------FIRINFDVAGYIVGANI--ETYLLE
KSRAIRQAKDECSFHI----FYQLLGGAG--EQLKADLLLEPFSHYRFLTNGPSSSPGQE
RE-LFQETLESLRVLGFTHEEITSMLRMVSAVLQFGNIVLKRERNTDQASMPDNTAAQKL
CRLLGLGVTDFSRALLTPRIK-VGRDYV----QKAQTKEQADFALEALAKATYERLFRWL
VLRLNRALDRSPRQGASFLGILDIAGFEIFQLNSFEQLCINY-TNEKLQQLFNHTMFVL-
-EQEEYQREGIPWTFLDFGLTASPCS--VNG-------------QANPPGLLALLDEECW
FPKATDK-SFVEKVAQEQGGHPKFQRPRHLRDQADFSVLHYAGKVDYKANEWLMKNMDPL
NDNVATLLHQSTDRLTAEIWKD--------------------------------------
------------VEGIVGLEQVSSLGDG-P-P-GGRPRRGMFRTVGQLYKESLSRLMATL
SNTNPSFVRCIIPNHEKRAGKLDPR---------LVL-----DQLRCNGVLEGIRICRQG
FPNRI-------------------LF--QEFRQRYEILTPNA---IPKGFMDGKQACEKM
IQALELDPNL-YRVGQSKIFFRAGVLAQLEEERDLKVTDIIVSFQAAARG--YLARKAFQ
K-RQQQQSALRVMQRNCAAYLKLRHWQWWR-----------------LFIKV--KPLLQV
TR--QDEVLQARAQELQKVLELQQQSARGVGELQGRVAQLEEERARLAEQLRSEAELCAE
A---EETRGRLAARKQ-ELELVVSEL----EAR-------VGEEEECSRQLQTEKKRLQQ
HIQELETHL------------EAEEGARQKLQLEKVTTEAKLKKLGE-DLLLLE---DQN
AKLSKERKLLEERLSEFSSQAAE--------EEEKVKSLNKLRLKYEATIADMEDRLRKE
EKSRQELGKLKRRLDVEGSE-LQEQMAE

PF01576 // ENSGT00760000118919_8_Domain_13 (1349, 2557)

QQQRAEE-LRAQLGR--KEEELQAALARAEEE
GGARAQLLKSLREAQAGLAEAQEDLEAERAARAKAEKQRRDLGEELEALRGELEDTLDST
NAQQELRK-RSKREQEVTELKKALEEETRIHEVAVQELRQRHGQALGELAEQLEQARRS-
--KGTWEKTRLTLEAEVSELRTELSNLQTARQEGEQRRRRLESQLQ--------------
------------------EVQG------RAGDGERARAE---------------------
-AAEKLQRAQAELENVSGALSEAESRAIRLSKELTSMEAQLHDAQELLQEETRAKRALGS
RARALEAEE------------------------------AAGRREQLDEEAAARERAGRE
----------LQAAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEVLNQ-----RLAE
KAEVVE---RLERGRRR-----------LQQELDDA------------------TVDLE-
---QQRQLVSALEKKQRKFDQLL----------AEEKAAVLRAGEERERA-----GREAR
TLSLTRALEEEQEAREE-----------------------LERQNRALRAELEALLSSKD
DVGKSVHELERARRVA--------EQAAS-DLRMQVTELED----ELTAA-EDAKLRLEV
TM---QALKAQHERGG-----AGGGGRRQLAKQLRDAEVERDEE-RKQRALAMAARK-KL
EAELEELKSQTTA-----------A-GQGKEEAVKQL---RK------------------
-MQA-QMKELWREVEETRSS-REEIF-AQNRESEKRLKLTTCL-FCSLQELAASDRARRQ
AQQERDEMADEVANGSLSKAAILDEKRQLEGRLGQMEEELEEEQSNAELLNDRYRKLLLQ
VESLTT---------ELSAERSFSAKAESGRQQLERQVQELRERLGEEDAGARAR--QKM
IIAALESKLAQAEEQLEQES----------------------------------------
----------RERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKR
QLEEAEEEASRAQAVRRRLQHELEDVTEASESMNRELNTLRNRLR---------------
------------------------------------RGPLTFTTRTVRQVFRLEEGVASD
EEAAAEEAEPRSGPPPPEPEGSAAAPPQ--

MAAVTMSVPGRKAPPRPGPVPEAAQPFLFTPRGPSAGG----GPG-SGTSPQVEWTAR

PF02736 // ENSGT00760000118919_8_Domain_0 (59, 98)

RL
VW--VPSELHGFEAAALRDEGEEEAEVELAESGRRLR

ENSGT00760000118919_8_Linker_0_1 (98, 115)

LPRDQIQRMNPPKFSKA

PF00063 // ENSGT00760000118919_8_Domain_1 (115, 982)

EDMAEL
TCLNEASVLHNLRERYYSGLIYTYSGLFCVVINPYKQLPIYTEAIVEMYRGKKRHEVPPH
VYAVTEGAYRSMLQDR-EDQSILCTGESGAGKTENTKK--V---IQ-------YLAHVAS
SPKGRKEP-------GVP-----------------------------ASVSTVSYGELER
QLLQANPILEAFGNAKTVKNDNSS-RFGK------FIRINFDVAGYIVGANI--ETYLLE
KSRAIRQAKDECSFHI----FYQLLGGAG--EQLKADLLLEPCSHYRFLTNGPSSSPGQE
RE-LFQETLESLRVLGFSHEEIISMLRMVSAVLQFGNIALKRERNTDQATMPDNTAAQKL
CRLLGLGVTDFSRALLTPRIK-VGRDYV----QKAQTKEQADFALEALAKATYERLFRWL
VLRLNRALDRSPRQGASFLGILDIAGFEIFQLNSFEQLCINY-TNEKLQQLFNHTMFVL-
-EQEEYQREGIPWTFLDFGLDLQPCIDLIER-------------PANPPGLLALLDEECW
FPKATDK-SFVEKVAQEQGGHPKFQRPRHLRDQADFSVLHYAGKVDYKANEWLMKNMDPL
NDNVAALLHQSTDRLTAEIWKDEHGGFQQFSFLGSFPPSPPGSAERCSSAISPPGV----
-------------EGIVGLEQVSSLGDG-P-P-GGRPRRGMFRTVGQLYKESLSRLMATL
SNTNPSFVRCIVPNHEKRAGKLEPR---------LVL-----DQLRCNGVLEGIRICRQG
FPNRI-------------------LF--QEFRQRYEILTPNA---IPKGFMDGKQACEKM
IQALELDPNL-YRVGQSKIFFRAGVLAQLEEERDLKVTDIIVSFQAAARG--YLARRAFQ
K-RQQQQSALRVMQRNCAAYLKLRHWQWWR-----------------LFTKV--KPLLQV

PF01576 // ENSGT00760000118919_8_Domain_13 (1081, 2504)

TR--QDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAE
A---EETRGRLAARKQ-ELELVVSEL----EAR-------VGEEEECSRQMQTEKKRLQQ
HIQELEAHL------------EAEEGARQKLQLEKVTTEAKMKKFEE-DLLLLE---DQN
SKLSKERKLLEDRLAEFSSQAAE--------EEEKVKSLNKLRLKYEATIADMEDRLRKE
EKGRQELEKLKRRLDGESSE-LQEQMVEQQQRAEE-LRAQLGR--KEEELQAALARAEDE
GGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDST
NAQQELR---SKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRG-
--KGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQ--------------
------------------EVQG------RAGDGERARAE---------------------
-AAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGS
RVRAMEAE-------------------------------AAGLREQLEEEAAARERAGRE
----------LQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQ-----RLAE
KTETVD---RLERGRRR-----------LQQELDDA------------------TMDLE-
---QQRQLVSTLEKKQRKFDQLL----------AEEKAAVLRAVEERERAEAEGREREAR
ALSLTRALEEEQEAREE-----------------------LERQNRALRAELEALLSSKD
DVGKSVHELERACRVA--------EQAAN-DLRAQVTELED----ELTAA-EDAKLRLEV
TV---QALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEE-RKQRTLAVAARK-KL
EGELEELKAQMAS-----------A-GQGKEEAVKQL---RK------------------
-MQA-QMKELWREVEETRTS-REEIF-SQNRESEKRLKGLEAEVLRLQEELAASDRARRQ
AQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQ
VESLTT---------ELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARAR--HKM
TIAALESKLAQAEEQLEQET----------------------------------------
----------RERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKR
QLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLR---------------
------------------------------------RGPLTFTTRTVRQVFRLEEGVASD
EE--AEEAQPGSGPS-PEPEGSPPAHPQ--

MAAVTMSVPGRKAASRPGPVPEAAQPYLA-PHASGTGGGPGSWPGGAGTSPHVEWTARRM
VW--VPSELHGFEAALMDEDEDAEL--LL-----WRLLPRD-QQRMN-PKFSKAXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXX

PF00063 // ENSGT00760000118919_8_Domain_1 (193, 982)

XXXXREDQSILCTGESGAGKTENTKK--V---IQ-------YLAHVAS
SPKGRKEPGVP--------------------------------------------GELER
QLLQANPILEAFGNAKTVKNDNSS-RFGK------FIRINFDVAGYIVGANI--ETYLLE
KSRAIRQAKDECSFHI----FYQLLGGAG--EQLRXXXXXXXXXXXXXXXXXXXXXXX-X
XXXXXXXXXXXXXXXXXXXXXXXXMLRMVSAVLQFGNIVLKKERNTDQATMPDNTAAQKL
CRLLGLGVTDFSRALLTPRIK-VGRDYV----QKAQTKEQADFALEALAKATYERLFRWL
VLRLNRALDRSPRQGASFLGILDIAGFEIFQLNSFEQLCINY-TNEKLQQLFNHTMFIL-
-EQEEYQREGIPWTFLDFGLDLQPCIDLIER-------------PANPPGLLALLDEECW
FPKATDK-SFVEKVAQEQGGHPKFQRARQLRDQADFSVLHYAGKVDYKANEWLMKNMDPL
NDTVAALLHQSTDRLTAEIWKDEHGGFQQFSLLGSFSPSPPGS---------AERCSSAV
SP--------SGVEGIVGLEQVSSLGDG-P-P-GGRPRRGMFRTVGQLYKESLSRLMATL
SNTNPSFVRCIVPNHEKRAGKLEPR---------LVL-----DQLRCNGVLEGIRICRQG
FPNRI-------------------LF--QEFRQRYEILTPNA---IPKGFMDGKQACEKM
IQALELDPNL-YRVGQSKIFF

ENSGT00760000118919_8_Linker_1_12 (982, 998)

RAGVLAQLEEERDLKV

PF00612 // ENSGT00760000118919_8_Domain_12 (998, 1020)

TDIIVSFQAAARG--YLARRAFQ
K-RQQQQSALRVMQRNCAAYLKLRHWQWWR-----------------LFTKV--KPLLQV
TR--QDEVLQAQVQELQKVQELQQQSAREVGELQARLAQVEEERARLADQLRAEAELCSE
A---EEMRGRLAARKQ-ELELVVSEL----ETR-------VGEEEECSRQLQTEKKRLQQ
HIQXXXXXXXXXXXXXXXXXXXXXX-------------XXXXXXXXXXXXXXXX---XXX
XXXXXERKLLEERLTEFSSQAAE--------EEEKVKSLNKLRLKYEATIADMEDRLRKE
EKGRQELEKLKRRMDGESSE-LQEQMV

PF01576 // ENSGT00760000118919_8_Domain_13 (1348, 2557)

EHKQRAEE-MRAQLGR--KEEELQAALARAVEE
GGARAQLLKSLREAQAGLAEAQEDLEAERVARAKAEKQRRDLGEELEALRSELEDTLDST
NAQQELR---SKREQEVTELKKALEDETRAHEVAVQDLRQRHGQALGELSEQLEQARRG-
--KSVWEKARVALEAEVSELRTELSSLQTTRQEGEQRRRRLESQLQ--------------
------------------EVQG------RASDGERARAE---------------------
-AAEKLQRAQAELENVSGALNEAESRAIRLSKELSSTEAQLHDAQEMLQEETRAKLALGS
RVRALESE-------------------------------AVGLREQLEEEAASRERAGRE
----------LQAAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQ-----RLAE
KTEAVE---RLDRGRRQ-----------LQQELDDA------------------TMDLE-
---QQRQLVSTLEKKQRKFDQXX----------XXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXX-----------------------XXXXXXXXXXXXXXXXXXXX
XXXXXVHELERARRVA--------EQAAS-DLRTQVTELED----ELTAA-EDAKLRLEV
TV---QALKSQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEE-RKQRALAVATRK-KL
EAELEELKAQMAS-----------A-GQGKEEAVKQL---RK------------------
-MQA-QMKELWREVEESRTS-REEIF-VQNRESEKRLKGLEAEVLRLQEELAASDRARRQ
AQQERDEMADEVASGNLGRAAILEEKRQLEGR-GQLEEELEEEQSNAELVNDRYRKLLLQ
VESLTT---------ELSAERGFSAKAESGRQQLERQIQELRGRLGEEDAGTRAR--QKM
VIAALESKLAQAEEQLEQET----------------------------------------
----------RERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQMEKGNLRVKQLKR
QLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLR---------------
------------------------------------RGPLTFTTRTVRQVFRLEEGVASD
EE--AEEAEPGAGATQAEPDGPGQAPPQ--

MAAVTVSVPGRKAPPRPGPVPEAAQPFLFAPRGPGVGS----GPGGSATSPQVEWTAR

PF02736 // ENSGT00760000118919_8_Domain_0 (59, 98)

RL
VW--VPSELHGFEAAALRDEGEEEAEVELAESGRRLR

ENSGT00760000118919_8_Linker_0_1 (98, 115)

LPRDQIQRMNPPKFSKA

PF00063 // ENSGT00760000118919_8_Domain_1 (115, 982)

EDMAEL
TCLNEASVLHNLRERYYSGLIYTYSGLFCVVINPYKQLPIYTEAIVEMYRGKKRHEVPPH
VYAVTEGAYRSMLQDR-EDQSILCTGESGAGKTENTKK--V---IQ-------YLAHVAS
SPKGRKEPGVPASASTV------------------------------------SYGELER
QLLQANPVLEAFGNAKTVKNDNSS-RFGK------FIRINFDVAGYIVGANI--ETYLLE
KSRAIRQAKDECSFHI----FYQLLGGAG--EQLKADLLLEPFSHYRFLTNGPSSSPGQE
RE-LFQETLESLRVLGFTHEEITSMLRMVSAVLQFGNIVLKRERNTDQASMPDNTAAQKL
CRLLGLGVTDFSRALLTPRIK-VGRDYV----QKAQTKEQADFALEALAKATYERLFRWL
VLRLNRALDRSPRQGASFLGILDIAGFEIFQLNSFEQLCINY-TNEKLQQLFNHTMFVL-
-EQEEYQREGIPWTFLDFGLDLQPCIDLIER-------------PANPPGLLALLDEECW
FPKATDK-SFVEKVAQEQGGHPKFQRPRHLRDQADFSVLHYAGKVDYKANEWLMKNMDPL
NDNVASLLHQSTDKLTAEIWKD--------------------------------------
------------VEGIVGLEQVSSLGEG-P-P-GGRPRRGMFRTVGQLYKESLSRLMATL
SNTNPSFVRCIVPNHEKRAGKLEPR---------LVL-----DQLRCNGVLEGIRICRQG
FPNRI-------------------LF--QEFRQRYEILTPNA---IPKGFMDGKQACEKM
IQALELDPNL-YRVGQSKIFFRAGVLAQLEEERDLKVTDIIVSFQAAARG--YLARKAFQ
K-RQQQQSALRVMQRNCAAYLKLRHWQWWR-----------------LFIKV--KPLLQV

PF01576 // ENSGT00760000118919_8_Domain_13 (1081, 2504)

TR--QDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERTRLAEQLRAEAELCAE
A---EETRGRLAARKQ-ELELVVSEL----EAR-------VGEEEECSRQLQTEKKRLQQ
HIQELEAHL------------EAEEGARQKLQLEKVTTEAKLKKFGE-DLLLLE---DQN
AKLSKERKLLEERLAEFSSQAAE--------EEEKVKSLNKLRLKYEATIADMEDRLRKE
EKSRQELEKLKRRLDVEGSE-LQEQMVEQQQRTEE-LRAQLGR--KEEELQAALARVEEE
GGARAQMLKSLREAQAGLAEAQEDLEAERAARAKAEKQRRDLGEELEALRGELEDTLDST
NAQQELR---SKREQEVTELKKALEEETRIHEVAVQELRQRHGQALGELAEQLEQARRS-
--KGTWEKTRLALEAEVSELRTELSNLQTARQEGEQRRRRLESQLQ--------------
------------------EVQG------RAGDGERARAE---------------------
-ATEKLQRAQAELENVSGALSEAESKAIRLSKELTSMEAQLHDAQELLQEETRAKLALGS
RARALEAE-------------------------------AAGLREQLEEEAAARERAGRE
----------LQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREVEALTQ-----RLTE
KTEVVE---RLERGRRR-----------LQQELDDA------------------TVDLE-
---QQRQLVSALEKKQRKFDQLL----------AEEKAAVLRAVEERERVEAEGREREAR
TLSLTRALEEEQEAREE-----------------------LERQNRALRAELEALLSSKD
DVGKSVHELERARRVA--------EQAAS-DLRTQVTELED----ELTSA-EDAKLRLEV
TV---QALKAQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEE-RKQRALAVAARK-KL
EADLEELKAQTVA-----------A-GQGKEEAVKQL---RK------------------
-MQA-QMKELWREVEESRSS-REEIF-AQNRESEKRLKGLEAEVLRLQEELAASDRARRQ
AQQERDEMADEVANGSLSKAAILDEKRQLEGRLGQLEEELEEEQSNAELLNDRYRKLLLQ
VESLTT---------ELSAERSFSAKAESGRQQLERQMQELRGRLGEEDAGARAR--QKM
IIAALESKLAQAEEQLEQES----------------------------------------
----------RERILSGKLVRRAEKRLKEVVLQVEEERRAADQLRDQLEKGNLRVKQLKR
QLEEAEEEASRAQAVRRRLQHELEDVTEASESMNRELNTLRNRLR---------------
------------------------------------RGPLTFTTRTVRQVFRLEEGVASD
EEAAEEEAEPGSGPPPPEPDGSPAAVPQ--

MAAVTMSVPGRKAAPRPGPVPEAAQPFLFTPRGPSAGG----GPG-SGTSPQVEWTAR

PF02736 // ENSGT00760000118919_8_Domain_0 (59, 98)

RL
VW--VPSELHGFEAAALRDEGEEEAEVELAESGRRLR

ENSGT00760000118919_8_Linker_0_1 (98, 115)

LPRDQIQRMNPPKFSKA

PF00063 // ENSGT00760000118919_8_Domain_1 (115, 982)

EDMAEL
TCLNEASVLHNLRERYYSGLIYTYSGLFCVVINPYKQLPIYTEAIVEMYRGKKRHEVPPH
VYAVTEGAYRSMLQGECWVGK----------------T--V---I--------AYGHTDT
QPAGDTPP-------APF-------------------------SLTSCIISCARQGELER
QLLQANPILEAFGNAKTVKNDNSS-RFGK------FIRINFDVAGYIVGANI--ETYLLE
KSRAIRQAKDECSFHI----FYQLLGGAG--EQLKADLLLEPCSHYRFLTNGPSSSPGQE
RE-LFQETLESLRVLGFTHEEIISMLRMVSAVLQFGNIALKRERNTDQATMPDNTAAQKL
CRLLGLGVTDFSRALLTPRIK-VGRDYV----QKAQTKEQADFALEALAKATYERLFRWL
VLRLNRALDRSPRQGASFLGILDIAGFEIFQLNSFEQLCINY-TNEKLQQLFNHTMFVL-
-EQEEYQREGIPWTFLDFGLDLQPCIDLIER-------------PANPPGLLALLDEECW
FPKATDK-SFVEKVAQEQGGHPKFQRPRHLRDQADFSVLHYAGKVDYKANEWLMKNMDPL
NDNVAALLHQSTDRLTAEIWKDEHGGFQQFSFLGSFP---------PSPPGSAERCS---
-SAIS----PPGVEGIVGLEQVSSLGDG-P-P-GGRPRRGMFRTVGQLYKESLSRLMATL
SNTNPSFVRCIVPNHEKRAGKLEPR---------LVL-----DQLRCNGVLEGIRICRQG
FPNRI-------------------LF--QEFRQRYEILTPNA---IPKGFMDGKQACEKM
IQALELDPNL-YRVGQSKIFFRAGVLAQLEEERDLKVTDIIVSFQAAARG--YLARRAFQ
K-RQQQQSALRVMQRNCAAYLKLRHWQWWR-----------------LFTKV--KPLLQV

PF01576 // ENSGT00760000118919_8_Domain_14 (1081, 1666)

TR--QDEVLQARAQELQKVQELQQQSAREVRELQGRVAQLEEERARLAEQLRAEAELCAE
A---EETRGRLAARKQ-ELELVVSEL----EAR-------VGEEEECSRQMQTEKKRLQQ
HIQELEAHL------------EAEEGARQKLQLEKVTTEAKMKKFEE-DLLLLE---DQN
SKLSKERKLLEDRLAEFSSQAAE--------EEEKVKSLNKLRLKYEATITDMEDRLRKE
EKGRQELEKLKRRLDGESSE-LQEQMVEQQQRAEE-LRSQLGR--KEEELQAALARAEDE
GGARAQLLKSLREAQAALAEAQEDLEAERVARTKAEKQRRDLGEELEALRGELEDTLDST
NAQQELR---SKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRG-
--KGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLESQLQ--------------
------------------EVQG------RAGDGERARAE---------------------
-AAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQVTLPALRCCKRRPGR
NWP-WG------------------------------------------------PGCEPW
----------RLRQPGCLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQ-----RLAE
KTEAVD---RLERGRRR-----------LQQELDDA------------------SVDLE-
---QQRQLVSTLEKKQRKFDQLL----------AEEKAAVLRAVEERERAEAEGREREAR
ALSLTRALEEEQEAREE-----------------------LERQNRALRAELEALLSSKD
DVGKSVHELERACRVA--------EQAAN-DLRAQVTELED----ELTAA-EDAKLRLEV
TV---QALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEE-RKQRALAVAARK-KL
EGELEELKAQMAS-----------A-GQGKEEAVKQL---RK------------------
-MQA-QMKELWREVEETRSS-REEIF-SQNRESEKRLKGLEAEVLRLQEELAASDRARRQ
AQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQ
VESLTT---------ELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARAR--HKM
TIAALESKLAQAEEQLEQET----------------------------------------
----------RERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQVST-------AKR
QPEESEEEVFRDQADRRRMQREREDLTESSESRNHEVTTLRNRIR---------------
------------------------------------RGPLTFTSRTVRQVFRLEEGVASD
EE--AEEAEPGSGPS-PEPEGSPPAHPQ--

MAAATLSMSGRKAXXXXXXXXXXXXXXXXXXXXXXXXX----XXXXX----XXXXXXXXX
XX--XXXXXXXXXXXXXXXXXXXEAEVELAESGRRLRLPRDQIQRMNPPKFSKA

PF00063 // ENSGT00760000118919_8_Domain_1 (115, 982)

EDMAEL
TCLNEASVLHNLRERYYSGLIYTYSGLFCVVINPYKQLPIYTEAIVEMYRGKKRHEVPPH
VYAVTEGAYRSMLQDR-EDQSILCTGESGAGKTENTKK--V---IQ-------YLAHVAS
SPKGRKEPGVPVSHL--------------------------------------PWGELER
QLLQANPVLEAFGNAKTVKNDNSS-RFGK------FIRINFDVAGYIVGANI--ETYLLE
KSRAIRQAKDECSFHI----FYQLLGGAG--EQLKADLLLEPSSHYRFLTNGLASTPSQE
RE-LFQETLESLRVLGFTPEEITSMLRMVSAVLQFGNVILKSERNTDQATMPDNTAAQKL
CRLLGLGVTDFSRALLTPRIK-VGRDYV----QKAQTKEQADFALEALAKATYERLFRWL
VLRLNRALDRSPRQGASFLGILDIAGFEIFQLNSFEQLCINY-TNEKLQQLFNHTMFVL-
-EQEEYQREGIPWTFLDFGLDLQPCIDLIER-------------PANPPGLLALLDEECW
FPKATDK-SFVEKVAQEQGGHPKFQRPRHLRDQADFSVLHYAGKVDYKANEWLMKNMDPL
NDNVAALLHQSTDRLTAEIWKD--------------------------------------
------------VEGIVGLEQVSSLGDG-P-P-GGRPRRGMFRTVGQLYKESLSRLMATL
SNTNPSFVRCIVPNHEKRAGKLEPR---------LVL-----DQLRCNGVLEGIRICRQG
FPNRI-------------------LF--QEFRQRYEILTPNA---IPKGFMDGKQACEKM
IQALELDPNL-YRVGQSKIFFRAGVLAQLEEERDLKVTDIIVSFQAAARG--YLARRAFQ
R-RQQQQSALRVMQRNCAAYLKLRHWQWWR-----------------LFIKV--KPLLQV
TR--QDEVLQARAQELQKVQELQQQSARQVGELQDRVTQVRGGME-----SGGRRELC--
-----------GRGKQ-ELELVVTEL----EAR-------MSEEEECSRQLQAEKRRLQL
HIQVHSDVGL---------PCK------------HLT---SFYSMGSNSCPAAP---DTA
S

PF01576 // ENSGT00760000118919_8_Domain_13 (1262, 2499)

WHSQERRLLEERLAEFSSQAAE--------EEEKIKSLNKLRLKYEATIADMEDRLRKE
EKGRQELEKLKRRLDGESSE-LQEQMAEQQQRAEE-LRAQLGR--KEEELQAALVRAEEE
GGARAQLLKSLREAQAGLAEAQEDLEAERAARAKAEKQRRDLSEELEALRGELEDTLDST
NAQQELR---TKREQEVTELKKALEEETRLHEVAVQELRQRQGQALGELVEQLEQARR--
-GKNAWEKTRLALEAEVSELRTELSNLQTSRQEGEQKRRRLESQLQ--------------
------------------EVQG------RAGDGERARVE---------------------
-ATEKLQRAQAELETVSGALSEAESKAIRLGKELSSTEGQLHDTQELLQEETRAKLALGS
RVRALEAE-------------------------------AAGLREQMEEEAAARERAGRE
----------LQAAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALAQ-----RLTE
KTEAVE---RLERGRHR-----------LQQELDDV------------------TVDLE-
---QQRQLVSTLEKKQRKFDQLL----------AEEKAAVLRAVEERERVEAEGREREAR
ALSLTRALEEEQXAREE-----------------------LERQNRALRAELEALLSSKD
DVGKSVHELERTRRVA--------EQAAN-DLRTQVTELED----ELTAA-EDAKLRLEV
TV---QALKAQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEE-RKQRALAVAARK-KL
ETELEELKAQAAP-----------A-THS-----------IL------------------
-PQV-QMKELWREVEESRTS-REEIF-VQNRESEKRLKSLEAEVLRLQEELAASDRARRQ
AQQDRDEMADEMANGSLSKAALLEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQ
VDTLTT---------ELSTERSFSAKAESGRQQLERQIQELRGHLGEEDAGARAR--QKM
TIATLESKLSQAEEQLEQES----------------------------------------
----------RERILSGKLLRRAEKRLKEVVLQVEEERRVADQLRDQLEKANLRVKQLKR
QLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTRAARARIHTHTPARAGPVLGQ
WRP---------------------------------EFPRPFLPRCLIER----------
------------------------------

---------------------------------------------------QVEWTA

PF02736 // ENSGT00760000118919_8_Domain_0 (58, 102)

RRL
VW--VPSEVHGFEAAALRDESEEEAEVELAESGKRLRLPRD

ENSGT00760000118919_8_Linker_0_1 (102, 114)

QIQRMNPPKFSK

PF00063 // ENSGT00760000118919_8_Domain_1 (114, 982)

AEDMAEL
TCLNEASVLHNLRERYYSGLIYTYSGLFCVVINPYKQLPIYTEAIVEMYRGKKRHEVPPH
VYAVTEGAYRSMLQDR-EDQSILCTGESGAGKTENTKK--V---IQ-------YLAHVAS
SPKGRKEPGVPXXXXXXXXXXXXXXX----------------------------------
----------------XXXXXXXX-XXXXXXXXGKFIRINFDIAGYIVGANIETXXXXXX
XXXXXXXXXXX--------XXXXXXXXXXXXXXXXXDLLLEPCSHYRFLTNGPSSSPGQE
RE-LFQETLESLRVLGFTHEEITSMLRTVSAVLQFGNVVLKRERNTDQATMPDNTAALKL
CRLLGLGVTDFSRALLTPRIK-VGRDYV----QKAQTKEQXXXALEALAKATYERLFRWL
VLRLNRALDRSPRQGASFLGILDIAGFEIFQLNSFEQLCINY-TNEKLQQLFNHTMFVL-
-EQEEYQREGIPWTFLDFGLDLQPCIDLIERPXXXXXXXXXXXXXXXXXXXXXXXX----
----X------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVDYKANEWLMKNMDPL
NDNVAALLHQSTDRLTAEIWKDEHGGFQQFSFLGSFP---------PSPPGPAGRCSSAL
S--------PSGVEGIVGLEQVSSLGDG-P-P-GGRPRRGMFRTVGQLYKESLSRLMATL
SNTNPSFVRCIVPNHEKRXXXXXXXXXX--------------XXXXXXXXLEGIRICRQG
FPNRI-------------------LF--QEFRQRYEILTPNA---IPKGFMDGKQACEKM
IQALELDPNL-YRVGQSKIFF

ENSGT00760000118919_8_Linker_1_12 (982, 998)

RAGVLAQLEEERDLKV

PF00612 // ENSGT00760000118919_8_Domain_12 (998, 1020)

TDIIVSFQAAARG--YLARXXX

ENSGT00760000118919_8_Linker_12_13 (1020, 1145)

X
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-----------------XXXXX--XXXXXX
XX--XXXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
A---

PF01576 // ENSGT00760000118919_8_Domain_13 (1145, 2557)

EETRGRLAA-KQ-ELELVVSEL----EAR-------VGEEEECSRQLQSEKKRLQQ
HIQELETHF------------EAEEGARQKLQLEKVTMEAKLKKFEE-DLLLVE---DQN
AKLSKERRLLEERLAEFSSQAAE--------EEEKIKSLNKLRLKYEATIADMEDRLRKE
EKGRQELEKLKRRLDGESSE-LQEQMVEQQQRAEE-LRAQLGR--KEEELQAALARVEDE
GGARAQLLKSLREAQAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XX-XXXX---XX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XGKSAWEKTRLALEAEVSELRAELSNLQTSRQEGEQRRRRLESQLQ--------------
------------------EVQG------RAGDGERARAE---------------------
-ATEKLQRAQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXX-------------------------------XXXXXXXXXX-X-XXXXXXXX
----------XXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXX-----XXXX
XXXXXXXXXXXXXXXXX-----------XXXXXXXX------------------XXXXX-
---XXXXXXXXXXXXXXXXXXLL----------AEEKAAVLRAVEERERVEAEGREREAR
ALSLTRALEEEQEAREE-----------------------LERQNRALRAELEALLSSKD
DVGKSVHELERARRVA--------EQAAN-DLRTQVTELED----ELTAA-EDAKLRLEV
TV---QALKAQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEE-RKQRAVAVAARK-KL
EAELEELKAQTEA-----------A-GQGREEAVKQL---RK------------------
-MQXXXXXXXXXXXXXXXXXXX--XX-XXXXXXXXXXXXXXXXXXXXXXELAASDRARRQ
AQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNAELLNDRYRKLLLQ
VESLTT---------ELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARAR--QKM
VIAALESKLAQAEEQLEQES----------------------------------------
----------RERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRLKQLKR
QLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLR---------------
------------------------------------RGPLTFTTRTVRQVFRLEEGVASD
EE--VEEAEPGSGPPPTEPEGPQPAQPQ--

------------------------------------------------------------
-----------------------------------------QIQRMNPPKFS

PF00063 // ENSGT00760000118919_8_Domain_1 (113, 982)

KA-EMAEL
TCLNESV-L-HNRERYYSGLIYTYSGLFCVVINPYKQLPIYTEAIVEMYRGKKRHEVPPH
VYAVTEGAYRSMLQDR-EDQSILCTGESGAGKTENTKK--V---IQ-------YLAHVAS
SPKGRKEPGVP--------------------------------------------GELER
QLLQANPILEAFGNAKTVKNDNSS-RFGK------FIRINFDVAGYIVGANI--ETYLLE
KSRAIRQAKDECSFHI----FYQLLGGAG--EQLKADLLLEPFSHYRFLTNGPSSSPGQE
RE-LFQETLESLRVLGFTHEEITSMLRMVSAVLQFGNIVLKRERNTDQASMPDNTAAQKL
CRLLGLGVTDFSRALLTPRIK-VGRDYV----QKAQTKEQADFALEALAKATYERLFRWL
VLRLNRALDRSPRQGASFLGILDIAGFEIFQLNSFEQLCINY-TNEKLQQLFNHTMFVL-
-EQEEYQREGIPWTFLDFGLDLQPCIDLIER-------------PANPPGLLALLDEECW
FPKATDK-SFVEKVAQEQGGHPKFQRPRTLRDQADFSVLHYAGKVDYKASEWLMKNMDPL
NDSVAALLHQSTDRLTAEIWKDEHGGLQQFSFLGSFP---------PSPPGSSGRRGSAI
--------SPSGVEGIVGLEQVNSLGDG-P-P-GGRPRRGMFRTVGQLYKESLSRLMATL
SNTNPSFVRCIIPNHEKRAGKLEPR---------LVL-----DQLRCNGVLEGIRICRQG
FPNRI-------------------LF--QEFRQRYEILTPNA---IPKGFMDGKQACEKM
IQALELDPNL-YRVGQSKIFF

ENSGT00760000118919_8_Linker_1_12 (982, 998)

RAGVLAQLEEERDLKV

PF00612 // ENSGT00760000118919_8_Domain_12 (998, 1020)

TDIIVSFQAAARG--YLARKAFQ
K-RQQQQSALRVMQRNCAAYLKLRHWQWWR-----------------LFIKX--XXXXXX
XX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
X---XXXXXXXXXXXX-XXXXXXXXX----XXX-------XXXXXXXXXXXXXXXXXXXX
XXXELETHL------------EAEEGARQKLQLEKVTTEAKLKKFGE-DLLLLE---DQN
AKLSKERKLLEERLVEFSSQXXX--------XXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXX-XXXXXX

PF01576 // ENSGT00760000118919_8_Domain_13 (1348, 2557)

XXXXXXXX-XXXXXXX--XXXXXXXXXXXAEDE
GGARAQLLKSLREAQAGLAEAQEDLEAERAARAKAEKQRRDLGEELEALRSELEDTLDST
NAQQELR---SKREQEVTELKKALEEETRVHEVAVQELRQRHGQALGELAEQLEQARRS-
--KGTWEKTRLALEAEVSELRTELSNLQTARQEGEQRRRRLESQLQ--------------
------------------EVQG------RAGDGERARAE---------------------
-AAEKLQRAQAELEIVSGALSEAESKAIRLSKELTSMEAQLHDAQELLQEETRAKLTLGS
RARALEAE-------------------------------AAGLREQLDEEAAARERAGRE
----------LQAAQAQLSEWRRRQEEEAGALEAGEEARRRATREVEALTQ-----RLAE
KTEVVE---RLERGRRR-----------LQQELDDA------------------TVDLE-
---QQRQLVSALEKKQRKFDQLL----------AEEKAAVLRAVEERERVEAEGREREAR
ALSLTRALEEEQEAREE-----------------------LERQNRALRAELEALLSSKD
DVGKSVHELERARRVA--------EQAAN-DLRTQVTELED----ELTAA-EDAKLRLEV
TV---QALKAQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEE-RKQRALAVAARK-KL
EAELEELKAQTAA-----------S-GQGKEEAVKQL---RK------------------
-MQA-QMKELWREVEESRSS-REEIF-AQNRESEKRLKGLEAEVLRLQEELAASDRARRQ
AQQERDEMADEVANGSLSKAAILDEKRQLEGRLGQMEEELEEEQSNAELLNDRYRKLLLQ
XXXXXX---------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXLGEEDAGARTR---QM
IIAALESKLAQSEEQLEQES----------------------------------------
----------RERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKR
QLEEAEEEASRAQAVRRRLQHELEDVTEASESMNRELNTLRNRLR---------------
------------------------------------RGPLTFTTRSVRQVFRLEEGVVSD
EEAAAEEAEPGAGPLPAEPEGSPAAPTQ--

MAAVTLSVPGRKVAARPGPVPEAAQSFLFTPRTPSVGG----PG-----GPQVDWTAR

PF02736 // ENSGT00760000118919_8_Domain_0 (59, 98)

RL
VW--VPSELHGFEAAALRDEGEEEAEVELAESGRRLR

ENSGT00760000118919_8_Linker_0_1 (98, 115)

LPRDQIQRMNPPKFSKA

PF00063 // ENSGT00760000118919_8_Domain_1 (115, 982)

EDMAEL
TCLNEASVLHNLRERYYSGLIYTYSGLFCVVINPYKQLPIYTEAIVEMYRGKKRHEVPPH
VYAVTEGAYRSMLQDR-EDQSILCTGESGAGKTENTKK--V---IQ-------YLAHVAS
SPKGRKEPGVPVSHAALG---------------------------------HPRPGELER
QLLQANPILEAFGNAKTVKNDNSS-RFGK------FIRINFDVAGYIVGANI--ETYLLE
KSRAIRQAKDECSFHI----FYQLLGGAG--EQLKADLLLEPCSNYRFLTNGPSSFPGQE
RE-LFQETLESLRVLGFPPDEITAMLRMVSAVLQFGNIVLKKERNTDQATMPDNTAAQKL
CRLLGLGVTDFSRAILTPRIK-VGRDYV----QKAQTKEQADFALEALAKATYERLFRWL
VLRLNRALDRSPRQGASFLGILDMAGFEIFQLNSFEQLCINY-TNEKLQQLFNHTMFVL-
-EQEEYQREGIPWTFLDFGLDLQPCIDLIER-------------PANPPGLLALLDEECW
FPKATDK-SFVEKVAQEQGSHPKFQRPRHLRDQADFSILHYAGKVDYKVNEWLMKNMDPL
NDSVAALLHQSTDRLTAEIWKD--------------------------------------
------------VEGIVGLEQVSSLGDG-P-P-GGRPRRGMFRTVGQLYKESLSRLMATL
SNTNPSFVRCIVPNHEKRAGKLEPR---------LVL-----DQLRCNGVLEGIRICRQG
FPNRI-------------------LF--QEFRQRYEILTPNA---IPKGFMDGKQACEKM
IQALELDPNL-YRVGQSKVFFRAGVLAQLEEERDLKVTDIIVSFQAAARG--YLARRAFQ
R-RQQQQSALRVMQRNCAAYLKLRNWQWWR-----------------LFIKV--KPLLQV

PF01576 // ENSGT00760000118919_8_Domain_13 (1081, 2504)

TR--QDEVLQARAQELQKVQELHQQSAREVGELQSRVAQLEEERSRLAEQLRAEAELCSE
A---EETRARLSARKQ-ELELVVSEL----EAR-------VGEEEECSRQLQSEKKRLH-
-------HL------------EAEEGARQKLQLEKVTTEAKMKKFEE-DLLLLE---DQN
AKLSKERRLLEERLSEFSSQAAE--------EEEKVKSLNKLRLKYEATIADMEDRLKKE
EKGRQELEKLKRRLDGESSE-LQEQMLEHKQRAEE-LLAQLGR--KEDELQAALLRAEEE
GGARAQLLKSLREAQAGLAEAQEDLEAERAARAKAEKQRRDLGEELEALRGELEDTLDST
NAQQELR---SKREQEVTELKQTLEEETRAHEVAMQELRQRHGQALGELAEQLEQARR--
-GKGVWEKTRITLEAEVTELKTELSSLRTSRQEGEQKRRRLESQLQ--------------
------------------EVQG------RASDVDRARTE---------------------
-VAEKLQKAQAELETVSTALSEAESKAIRLSKELSSAESQLHDTQELLQEETRAKLALGS
RVRALEAE-------------------------------AAGLREQMEEEVVARERTARE
----------LQSAQVQLSEWRRRQEEEAGALEAGEEARRRAAREAEALAQ-----RLAE
KTEAVE---RLERARRR-----------LQQELDDA------------------TVDLG-
---QQKQLLSTLEKKQRKFDQLL----------AEEKAAVLRAVEDRERVEAEGREREAR
ALSLTRALEEEQEAREE-----------------------LERQNRALRAELDALLSSKD
DVGKNVHELERARRVA--------EQAAN-DLRTQVTELED----ELTAT-EDAKLRLEV
TV---QALKAQHERDLQGRDDAGEERRRQLAKQLRDAEVERDEE-RKQRALAVAARK-KL
EAELEELKAQMSA-----------------------------------------------
---T-QMKELWLEVEETRSS-REEIF-TLNRESEKRLKGLEAEVLRLQEELAASDRARRQ
AQQDRDEMAEEVATGNLSKAATLEEKRQLEGRLGQLEEELEEEQNNSEILRDHYRKLLLQ
VESLTT---------ELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARAR--QKM
LIAALESKLAQAEEQLEQES----------------------------------------
----------RERILSGKLVRRAEKRLKEVVLQVDEERRVADQLRDQLEKGNLRLKQLKR
QLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLR---------------
------------------------------------RGPLTFTTRTVRQVFRLEEGVASD
EEE-AEGAEPGPAPP-QEPEAPPLATPQ--

MAAVTMSVPGRKAPPRPGPVPEAAQPFLFTPRGPSAGG----GPG-SGTSPQVEWTAR

PF02736 // ENSGT00760000118919_8_Domain_0 (59, 98)

RL
VW--VPSELHGFEAAALRDEGEEEAEVELAESGRRLR

ENSGT00760000118919_8_Linker_0_1 (98, 115)

LPRDQIQRMNPPKFSKA

PF00063 // ENSGT00760000118919_8_Domain_1 (115, 982)

EDMAEL
TCLNEASVLHNLRERYYSGLIYTYSGLFCVVINPYKQLPIYTEAIVEMYRGKKRHEVPPH
VYAVTEGAYRSMLQDR-EDQSILCTGESGAGKTENTKK--V---IQ-------YLAHVAS
SPKGRKEP-------GVP-----------------------------TSVSTVSYGELER
QLLQANPILEAFGNAKTVKNDNSS-RFGK------FIRINFDVAGYIVGANI--ETYLLE
KSRAIRQAKDECSFHI----FYQLLGGAG--EQLKADLLLEPCSQYRFLTNGPSSSPGQE
RE-LFQETLESLRVLGFTHEEIISMLRMVSAVLQFGNIALKRERNTDQATMPDNTAAQKL
CRLLGLGVTDFSRALLTPRIK-VGRDYV----QKAQTKEQADFALEALAKATYERLFRWL
VLRLNRALDRSPRQGASFLGILDIAGFEIFQLNSFEQLCINY-TNEKLQQLFNHTMFVL-
-EQEEYQREGIPWTFLDFGLDLQPCIDLIER-------------PANPPGLLALLDEECW
FPKATDK-SFVEKVAQEQGGHPKFQRPRQLRDQADFSVLHYAGKVDYKANEWLMKNMDPL
NDNVAALLHQSTDRLTAEIWKDEHGGFQQFSFLGSFPPSPPGSAERCSSAVSPPGV----
-------------EGIVGLEQVSSLGDG-P-P-GGRPRRGMFRTVGQLYKESLSRLMATL
SNTNPSFVRCIVPNHEKRAGKLEPR---------LVL-----DQLRCNGVLEGIRICRQG
FPNRI-------------------LF--QEFRQRYEILTPNA---IPKGFMDGKQACEKM
IQALELDPNL-YRVGQSKIFFRAGVLAQLEEERDLKVTDIIVSFQAAARG--YLARRAFQ
K-RQQQQSALRVMQRNCAAYLKLRHWQWWR-----------------LFTKV--KPLLQV

PF01576 // ENSGT00760000118919_8_Domain_13 (1081, 2504)

TR--QDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERTRLAEQLRAEAELCAE
A---EETRGRLAARKQ-ELELVVSEL----EAR-------VGEEEECSRQLQTEKKRLQQ
HIQELEAHL------------EAEEGARQKLQLEKVTTEAKMKKFEE-DLLLLE---DQN
SKLSKERKLLEDRLSEFSSQAAE--------EEEKVKSLNKLRLKYEATIADMEDRLRKE
EKGRQELEKLKRRLDGESSE-LQEQMVEQQQRAEE-LRAQLGR--KEEELQAALARAEDE
GGARAQLLKSLREAQAALAEAQEDLEAERVARTKAEKQRRDLGEELEALRSELEDTLDST
NAQQELR---SKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRG-
--KGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLESQLQ--------------
------------------EVQG------RAGDGERARAE---------------------
-AAEKLQRAQAELENVSGALNEAESKAIRLSKELSSTEAQLHDAQELLQEETRAKLALGS
RVRAMEAE-------------------------------AAGLREQLEEEAAARERAGRE
----------LQTTQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQ-----RLAE
KTETVD---RLERGRRR-----------LQQELDDA------------------TMDLE-
---QQRQLVSTLEKKQRKFDQLL----------AEEKAAVLRAVEERERAEAEGREREAR
ALSLTRALEEEQEAREE-----------------------LERQNRALRAELEALLSSKD
DVGKSVHELERACRVA--------EQAAN-DLRAQVTELED----ELTAA-EDAKLRLEV
TV---QALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEE-RKQRTLAMAARK-KL
EGELEELKAQMAS-----------A-GQGKEEAVKQL---RK------------------
-MQA-QMKELWREVEETRSS-REEIF-SQNRESEKRLKGLEAEVLRLQEELAASDRARRQ
AAQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQ
VESLTT---------ELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARAR--HKM
TIAALESKLAQAEEQLEQET----------------------------------------
----------RERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKR
QLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLR---------------
------------------------------------RGPLTFTTRTVRQVFRLEEGVASD
EE--TEEAEPGSGPS-PEPEGSPPAHPQ--

MAAA------SMVRKAAGTVPEAAQPFLFTPRRPRAGE--------QHGAPQVEWAA

PF02736 // ENSGT00760000118919_8_Domain_0 (58, 102)

RRL
VW--VPSELHGFEAAALRDEGPEEVEVELAESGRRLRLPGD

ENSGT00760000118919_8_Linker_0_1 (102, 114)

QVQRMNPPKFSK

PF00063 // ENSGT00760000118919_8_Domain_1 (114, 982)

AEDMADL
TCLNEASVLHNLRERYYSSLIYTYSGLFCVVINPYKQLPIYTEAIVEMYRGKKRHEVPPH
VYAVTEAAYRSMLQDR-EDQSILCTGESGAGKTENTKK--V---IQ-------YLAHVAS
SPKGRREQGAP--------------------------------------------GELER
QLLQANPILEAFGNAKTVKNDNSS-RFGK------FIRINFDVAGYIVGANI--ETYLLE
KSRAIRQAKDECSFHI----FYQLLGGAG--EQL-KDLLLQPCSEYRFLTNGPASSPGQE
RE-LFHETLESLRVLGFTHDEIVXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXAQKL
CRLLGLGVTDFSRALLSPRIK-VGRDYV----QKAQTKEQADFALEALAKATYERLFRWL
VLRLNRALDRSPRQGASFLGILDIAGFEIFQLNSFEQLCINY-TNEKLQQLFNHTMFVL-
-EQEEYQREGIPWTFLDFGLDLQPCIDLIER-------------PANPPGLLALLDEECW
FPKATDK-SFVEKVAQEQGSHPKFQRPRQLRDQADFSVLHYAGKVDYKANEWLMKNMDPL
NDSVAALLHQSTDKLTAEIWKDXXXXXXXXXXXXXXXXXX-----------------XXX
XXXXXXXXXXXXXEGIVGLEQVSSLGDGGT-P-GGRPRRGMFRTVGQLYKESLSRLMATL
SNTNPSFVRCIIPNHEKRAGKLEPR---------LVL-----DQLRCNGVLEGIRICRQG
FPNRI-------------------LF--QEFRQRYEILTPNA---IPKGFMDGKQACEKM
IQALELDPNL-YRVGQSKIFF

ENSGT00760000118919_8_Linker_1_12 (982, 998)

RAGVLAQLEEERDLKI

PF00612 // ENSGT00760000118919_8_Domain_12 (998, 1020)

TDIIVSFQAAARG--YLARRAFH
R-RQQQQSALRVMQRNCAAYLKLRHWQWWR-----------------LFTKV--KPLLQV
TR--QDEVLQARAQELQKVQELQQQSARELDQLQGRLVQLEEERARLSEQLRAEAELCAE
A---EETRGRLAARKQ-ELETVVGML----EAR-------VGEEEERSVQLETEKKRLQQ
HVQELEQHL------------EAEEGARQKLQLXXXXXXXXXXXXXXXXXXXXX---XXX
XXXXXXXXXXXXXXXXXXXXXXX--------XXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXX-XXXXXX--XXXXXXX-XXXXXXXX

PF01576 // ENSGT00760000118919_8_Domain_13 (1350, 2557)

XXXXXX-XXXXXXXXXXXXXXXXXXXXAEEE
GGARATLLKSLREAQAGLAEAQEDLEAERAARTKAEKQRRDLGEELEALRGELEDTLDST
NAQQELR---TKREQEVSELKQALEEETRSHEAVVQELRQRHGQALGELGEQLEQARRG-
--KGAWEKTRLALEAEVSELRAELSSLQASRQEGDQRRRRLEGQLQ--------------
------------------ELQA------RAGDGERSRAE---------------------
-VADKLQRAQAELDSVSGALSEAESKVIRLSKELSSAEVQLHDAQEVLQEETRAKLALGS
RVRGLESE-------------------------------AAGLREQLEEEAVARERVGRE
----------LQTAQAQLAEWRRRQEEEAGALEAGEEARRRAAREAEALAQ-----RLAE
KTEVAE---RLERGRRQ-----------LQQELDDV------------------SMDLE-
---QQRHLVCSLEKKQKKFDQLL----------AEEKAVSQRAVEERERAEAEGREREAR
ALALTRALEEEREAREE-----------------------LERQNRALRAELEELLSRKD
DVGKSVHEMERARRAA--------EQAAA-DLRTQVTELED----ELMAA-EDAKLRLEV
TA---QALKAQHERELQGRDEAGEEKRRLLAKQLRDAEVERDEE-RKQRALALAARK-KA
ELELEELKAQVGS-----------A-GQGKEEAMKQL---RK------------------
-TQA-QMKELWREVEESRTS-REEIF-AQNRESEKRLKSLEAELLRLQEELAASDRARRQ
AQQDRDDMADEAANGNLARVALVEEKRNLEGRLXXXXXXXXXXXXXXXXXXXXXXXXXXX
VETLTT---------ELSAERSFSAKAESGRQQLERQLQELRGRLGEEDAGVRAR--HKM
LIAALESRLAQAEEQLEQESXXXXXXXXXXXXXXXXX-----------------------
---------------------------XXXXXXXXXXXXXXXXXXXXLEKGNLRLKQLKR
QLEEAEEEASRAQAGRRRLQRELDDVTESAESMNREVTTLRNRLR---------------
------------------------------------RGPLTFTTRTVRQVFRLEEGVGSD
EEEGEEA--GEAGPPPPEPDVPPQSQPQ--

------------------------------------------------------------
----------------------------------------DQVQRMNPPKFSKA

PF00063 // ENSGT00760000118919_8_Domain_2 (115, 146)

EDMADL
TCLNEASVLHNLRERYYSGLIYVSV

ENSGT00760000118919_8_Linker_2_1 (146, 326)

GLGPRAPDPSP--------------GEKRG-----
----------------------SCPAGSGPGQAPVPPGHSVSPSINGLPDSDNLWGPPLL
RPQSPASPGSGSSQEP--------PPQGGRLQNTGGDL--------VPSLPRSPHPPM-N
QEPPLRPSLEDKGVGQFWGDSASAL

PF00063 // ENSGT00760000118919_8_Domain_1 (326, 610)

KGSSSPSQGKFIRINFDVAGYIVGANI--ETYLLE
KSRAIRQAKDECSFHI----FYQLLGGAG--EQLKEDLLLQPCSEYRFLTNGPASSPGQE
RE-LFHETLESLRVLGFTHEEIISMLRVVSAVLQFGNISLKKERHSDQATMPDNTAAQKL
CRLLGLGVTDFSRALLSPRIK-VGRDYV----QKAQTKEQADFALEALAKASYERLFRWL
VLRLNRALDRSPRQGASFLGILDIAGFEIFQLNSFEQLCINY-TNEKLQQLFNHTMFVL-
-EQEEYQXEGGAGPGANGD------------DAPPP---------SSGPCGGGCR---DW
GRRFGAP--VAEPERQESVASPRV------RDLSPAPPPLRSPQVDYKANEWLMKNMDPL
NDSVAALLHQSTDKLTAEIWK---------------------------------------
-----------DVEGIVGLEQVSGLGDGTV-PGGGRPRRGMFRTVGQLYKESLSRLMATL
SNTNPSFVRCIIPNHEKRAGKLEPR---------LVL-----DQLRCNGVLEGIRICRQG
FPNRI-------------------LF--QEFRQRYEILTPNA---IPKGFMDGKQACEKM
VRGRAWSGRC-LE---GRGFGAAGVGGAGL-----------------------EGESCCP
PPPA----CLP-PNILCPSSDIPCSVSWDPATFH---VLSPGTPRRSMFCLLRPPPMFRV
LS--PPPTFHVLSPETPPNVPCSVPWDPPDV--PCSV-SWDPPNILFPEIPPRHSTFCVL
EHSFQRANGAVAPPRP-PPSLT------------------HGDGWPC-------------
-------HWP-------------RPGPR-----------------------SVG---DPH
GCLGLCRPSGK-------------------------R--PFLLLSTTSSAPIPIERLKLE
EKSRQELEKTKRRLDGESSE-LQEQMLE

PF01576 // ENSGT00760000118919_8_Domain_13 (1349, 1993)

QQRRADE-LRAQLGR--KEDELQAALARAEEE
SSSRATLLKSLREAQAGLAEAQEDLEAERVARAKAEKQRRDLGEELEALRGELEDTLDST
NAQQELR---TKREQEVSELKQALEEEARSHEAAVQELRQRHSQAVGELGEQLEQARRG-
--KGIWEKSRLALEAEVSELRSELGSLQASRQEGEQRRRRIEAQLQ--------------
------------------ELEA------RAGDGERARAE---------------------
-AADKLQRAQAELDSVSGSLSEAESKVIRLSKELSSAEVQLHDTQELLQEETRAKLALGS
RVRGLESE-------------------------------AAGLREQLEEEAAARERAARE
----------LQSAQAQVRH--KGTEGGAGALRAGEEARRRAAREAEALTQ-----RLAE
KTEVAE---RLERGRRQ-----------LQQELDDV------------------SMDLE-
---QQRHLVSSLEKKQKKFDQLL----------AEEKAVSLRAVEERERAEAEGREREAR
ALALARALEEEREAREE-----------------------LERQNRALRAEMEELLSSKD
DVGKSFNTLRFLKHAG--------REKSEQSGEPWERETRD----KECRE-QADSVSLDH
FL---SYTLMVYTRDMEWRRAQGTLSAHA---PLTATTML---------GKALYKPK-PW
EASALMLKDTMPRKTPGCAREVREA-SPGCM-TLASS---RP------------------
-SLQAQMKELWREVEESRTS-REEIF-AQNRENEKRLKSLEAELLRLQE-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------

MAAVTMSLPGRKATPRPGPVPEAAQPFLFTPRGPSAGV----GPG-SGTSPQVEWTAR

PF02736 // ENSGT00760000118919_8_Domain_0 (59, 98)

RL
VW--VPSELHGFEAAALRDEGEEEAEVELAESGRRLR

ENSGT00760000118919_8_Linker_0_1 (98, 115)

LPRDQIQRMNPPKFSKA

PF00063 // ENSGT00760000118919_8_Domain_1 (115, 993)

EDMAEL
TCLNEASVLHNLRERYYSGLIYTYSGLFCVVINPYKQLPIYTEAIVEMYRGKKRHEVPPH
VYAVTEGAYRSMLQDR-EDQSILCTGESGAGKTENTKK--V---IQ-------YLAHVAA
SPKGRKEPGVPASASTV------------------------------------SYGELER
QLLQANPILEAFGNAKTVKNDNSS-RFGK------FIRINFDVAGYIVGANI--ETYLLE
KSRAIRQAKDECSFHI----FYQLLGGAG--EQLKADLLLEPCSHYRFLTNGPSSSPGQE
RE-LFQETLESLRVLGFTHEEIILLMGSW---------------------CLSPSAAQKL
CHLLGLGVTDFSRALLTPRIK-VGRDYV----QKAQTKEQADFALEALAKATYERLFRWL
VLRLNRALDRSPRQGASFLGILDIAGFEIFQLNSFEQLCINY-TNEKLQQLFNHTMFVL-
-EQEEYQREGIPWTFLDFGLDLQPCIDLIER-------------PANPPGLLALLDEECW
FPKATDK-SFVEKVAQEQGGHPKFQRPRHLRDQADFSVLHYAGKVDYKANEWLMKNMDPL
NDSVAALLHQSTDRLTAEIWKDEHGGFQQFAFLGSFP---------PSPPGSAGKCSSAV
SP--------PGVEGIVGLEQVSSLGDG-P-P-GGRPRRGMFRTVGQLYKESLSRLMATL
SNTNPSFVRCIVPNHEKRAGKLEPR---------LVL-----DQLRCNGVLEGIRICRQG
FPNRI-------------------LF--QEFRQR--------------------------
-----------------KIFFRAGVLAQLEEERDLKVTDIIVSFQAAARG--YLARRAFQ
K-RQQQQSALRVMQRNCAAYLKLRHWQWWR-----------------LFTKV--KPLLQV

PF01576 // ENSGT00760000118919_8_Domain_13 (1081, 1882)

TR--QDDVLQARAQELQKAQELQQQSLREVGELRSRMAELEEERTRLAEQLRAEAELCAE
A---EETRGRLAARKQ-ELELVVSEL----EAR-------VGEEEECSRQLQTEKRRLQQ
HIQVWPPACPADPSVHPHLCFSKPCGARQKLQLEKVTTEAKMKKFEE-DLLLLE---DQN
SKLSKERKLLEDRLAEFSSQAAE--------EEEKVKSLNKLRLKYEATIADMEDRLRKE
EKSRQELEKLKRRLDGESSE-LQEQMAEQQQRAED-LRSQLGR--KEEELQAALARAEDE
GGARAQLLKSLREVQAALAEAQEDVEAERVARAKAEKQRRDLGEELEALRGELEDTLGST
NAQQELR---SKREQEVTELKKALEEETRIHEAAVQELRQRHGQALGELAEQLEQARRG-
--KGAWEKTRLALEAEVSELRVELSSLQTARQEGEQRRRRLESQLQ--------------
------------------EVQG------RAGDGERARAE---------------------
-TAEKLQRAQAELENVSGALNEAESKAIRLSKELSSMDAQLHDAQELLQEETRAKLALGS
RVRAMEAE-------------------------------AAGLREQLEEEAAARERAGRE
----------LQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQ-----RLAE
KTETVD---RLERGRRR-----------LQQELDDA------------------TVDLE-
---QQRQLVSTLEKKQRKFDQ

PF01576 // ENSGT00760000118919_8_Domain_14 (1081, 1882)

TR--QDDVLQARAQELQKAQELQQQSLREVGELRSRMAELEEERTRLAEQLRAEAELCAEA---EETRGRLAARKQ-ELELVVSEL----EAR-------VGEEEECSRQLQTEKRRLQQHIQVWPPACPADPSVHPHLCFSKPCGARQKLQLEKVTTEAKMKKFEE-DLLLLE---DQNSKLSKERKLLEDRLAEFSSQAAE--------EEEKVKSLNKLRLKYEATIADMEDRLRKEEKSRQELEKLKRRLDGESSE-LQEQMAEQQQRAED-LRSQLGR--KEEELQAALARAEDEGGARAQLLKSLREVQAALAEAQEDVEAERVARAKAEKQRRDLGEELEALRGELEDTLGSTNAQQELR---SKREQEVTELKKALEEETRIHEAAVQELRQRHGQALGELAEQLEQARRG---KGAWEKTRLALEAEVSELRVELSSLQTARQEGEQRRRRLESQLQ--------------------------------EVQG------RAGDGERARAE----------------------TAEKLQRAQAELENVSGALNEAESKAIRLSKELSSMDAQLHDAQELLQEETRAKLALGSRVRAMEAE-------------------------------AAGLREQLEEEAAARERAGRE----------LQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQ-----RLAEKTETVD---RLERGRRR-----------LQQELDDA------------------TVDLE----QQRQLVSTLEKKQRKFDQVG----------TSVHPAAE-------------------
---------------------------------------------------------PAS
PSVLPVHELERACRVA--------EQAAN-DLRAQVTELED----ELTAA-EDAKLRLEV
TV---QALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEE-RKQRALAVAARK-KL
EGELEELKAQLVS-----------A-GQGKEEAVKQL---RK------------------
-MQA-QMKELWREVEESRSS-REEIF-AQNRESDKRLKGLEAEVLRLQEELAASDRARRQ
AQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQ
VESLTS---------ELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARAR--QKM
TIAALESKLAQAEEQLEQES----------------------------------------
----------SSGLSRREE-----------VMAVPGDVT-WAPALAKLEKGNLRVKQLKR
QLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLR---------------
------------------------------------RGPLTFTTRTVRQVFRLEEGVASD
EE--AEDAEPGSGPS-PEPEGSPSAHPQ--

MAAVTLSVPGRKVAARAGPVPEAAQPFLFTPRTPNVGG----PG-----GPQVEWTAR

PF02736 // ENSGT00760000118919_8_Domain_0 (59, 98)

RL
VW--VPSELHGFEAAALRDEGEEEAEVELAESGRRLR

ENSGT00760000118919_8_Linker_0_1 (98, 115)

LPRDQIQRMNPPKFSKA

PF00063 // ENSGT00760000118919_8_Domain_1 (115, 982)

EDMAEL
TCLNEASVLHNLRERYYSGLIYTYSGLFCVVINPYKQLPIYTEAIVEMYRGKKRHEVPPH
VYAVTEGAYRSMLQDR-EDQSILCTGESGAGKTENTKK--V---IQ-------YLAHVAS
SPKGRKEPGVPASIST------------------------------------MSYGELER
QLLQANPILEAFGNAKTVKNDNSS-RFGK------FIRINFDVAGYIVGANI--ETYLLE
KSRAIRQAKDECSFHI----FYQLLGGAG--EQLKADLLLEPCSHYRFLTNGPSSSPGQE
RE-LFQETLESLRVLGFLPDEITAMLRTVSAVLQFGNIVLKRERNTDQATMPDNTAAQKL
CRLLGLGVTDFSRALLTPRIK-VGRDYV----QKAQTKEQADFALEALAKATYERLFRWL
VLRLNRALDKSPRQGASFLGILDIAGFEIFQLNSFEQLCINY-TNEKLQQLFNHTMFVL-
-EQEEYQREGIPWTFLDFGLDLQPCIDLIER-------------PANPPGLLALLDEECW
FPKATDK-SFVEKVAQEQGSHPKFQRPRHLRDQADFSVLHYAGKVDYKASEWLMKNMDPL
NDNVAALLHQSTDRLTAEIWKD--------------------------------------
------------VEGIVGLEQVSSLGDG-P-P-GGRPRRGMFRTVGQLYKESLSRLMATL
SNTNPSFVRCIVPNHEKRAGKLEPR---------LVL-----DQLRCNGVLEGIRICRQG
FPNRI-------------------LF--QEFRQRYEILTPNA---IPKGFMDGKQACEKM
IQALELDPNL-YRVGQSKIFFRAGVLAQLEEERDLKVTDIIVSFQAAARG--YLARRAFQ
R-RQQQQSALRVMQRNCAAYLKLRNWQWWR-----------------LFIKV--KPLLQV

PF01576 // ENSGT00760000118919_8_Domain_13 (1081, 2504)

TR--QDEVLQARAQELQKVQELQQQSAREVGELQSRVAQLEEERSRLAEQLRAEAELCSE
A---EETRARLSARKQ-ELELVVSEL----EAR-------VGEEEECSRQLQGEKKRLQQ
HIQELESHL------------EAEEGARQKLQLEKVTTEAKMKKFEE-DLLLLE---DQN
AKLSKERRLLEERLSEFSSQAAE--------EEEKVKSLNKLRLKYEATIADMEDRLKKE
EKGRQELEKLKRRLDGESSE-LQEQMVEQKQRAEE-LLAQLGR--KEDELQAALVRAEEE
GGARAQLLKSLREAQAGLAEAQEDLETERAARAKAEKQRRDLGEELEALRGELEDTLDST
NAQQELR---SKREQEVTELKKTLEEETRAHEVAMQELRQRHGQALGELAEQLEQARR--
-GKGVWEKTRLTLEAEVTELRAELSSLRTSRQEGEQKRRRLESQLQ--------------
------------------EVQG------RASDVDRARTE---------------------
-AAEKLQRAQAELESVSTALSEAESKAIRLGKELSSAESQLHDTQELLQEETRAKLALGS
RVRALEAE-------------------------------AAGLREQMEEEVVARERAGRE
----------LQSAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAETLAQ-----RLAE
KTEAVE---RLERARRR-----------LQQELDDA------------------TVDLG-
---QQKQLLSTLEKKQRKFDQLL----------AEEKAAVLRAVEDRERVEAEGREREAR
ALSLTRALEEEQEAREE-----------------------LERQNRALRAELEALLSSKD
DVGKNVHELERARRVA--------EQAAN-DLRTQVTELED----ELTAT-EDAKLRLEV
TV---QALKAQHERDLQGRDDAGEERRKQLVKQLRDAEVERDEE-RKQRALAVAARK-KL
EAELEELKAQTSA-----------A-GQGKEEAVKQL---RK------------------
-MQV-QMKELWREVEETRSS-REEIF-TLNKESEKRLKGLEAEVLRLQEELAASDRARRQ
AQQDRDEMAEEVATGNLSKTAILEEKRQLEGRLGQLEEELEEEQNNSEILRDHYRKLLLQ
VESLTT---------ELSAERSFSAKAESGRQQLERQIQELKSRLGEEDAGARAR--QKM
LIAALESKLAQAEEQLEQES----------------------------------------
----------RERILSGKLVRRAEKRLKEVVLQVDEERRVADQLRDQLEKGNLRLKQLKR
QLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLR---------------
------------------------------------RGPLTFTTRTVRQVFRLEEGVASD
EEE-AEGAERGPAPP-QEPEAPSLATPQ--

------------------------------------------------------------
------------------------------------------------------------
---------------------TYSV

PF00063 // ENSGT00760000118919_8_Domain_1 (146, 982)

VVICVVINPYKQLPIYTEAIVEMYRGKKRHEVPPH
VYAVTEGAYRSMLQGD---------GESGAGKTENTKK--V---IQ-------YLAHVAS
SPKGRK-----E-----------------------------------PGVPVSTPGELER
QLLQANPILEAFGNAKTVKNDNSS-RFGK------FIRINFDVAGYIVGANI--ETYLLE
KSRAIRQAKDECSFHI----FYQLLGGAG--EQLKADLLLEPCSQYRFLTNGPSSSPSQE
RE-LFQETLESLRVLGFTHEEIILLIGSWC---------------------LSPSAAQKL
CRLLGLGVTDFSRALLTPRIK-VGRDYV----QKAQTKEQADFALEALAKATYERLFRWL
VLRLNRALDRSPRQGASFLGILDIAGFEIFQLNSFEQLCINY-TNEKLQQLFNHTMFVL-
-EQEEYQREGIPWTFLDFGLDLQPCIDLIER-------------PANPPGLLALLDEECW
FPKATDK-SFVEKVAQEQGGHPKFQRPRQLRDQADFSVLHYAGKVDYKANEWLMKNMDPL
NDNVAALLHQSTDRLTAEIWKDEHGGFQQFSFLGSFP---------PSPPGSAERCSSAI
SPPG--------VEGIVGLEQVSSLGDG-P-P-GGRPRRGMFRTVGQLYKESLSRLMATL
SNTNPSFVRCIVPNHEKRAGKLEPR---------LVL-----DQLRCNGVLEGIRICRQG
FPNRI-------------------LF--QEFRQRYEILTPNA---IPKGFMDGKQACEKM
IQALELDPNL-YRVGQSKIFFRAGVLAQLEEERDLKVTDIIVSFQAAARG--YLARRAFQ
K-RQQQQSALRVMQRNCAAYLKLRHWQWWR-----------------LFTKV--KPLLQV

PF01576 // ENSGT00760000118919_8_Domain_13 (1081, 2504)

TR--QDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERTRLAEQLRAEAELCAE
A---EETRGRLAARKQ-ELELVVSEL----EAR-------VGEEEECSRQLQTEKKRLQQ
HIQELEAHL------------EAEEGARQKLQLEKVTTEAKMKKFEE-DLLLLE---DQN
SKLSKERKLLEDRLSEFSSQAAE--------EEEKVKSLNKLRLKYEATIADMEDRLRKE
EKGRQELEKLKRRLDGESSE-LQEQMVEQQQRAEE-LRAQLGR--KEEELQAALARAEDE
GGARAQLLKSLREAQAALAEAQEDLEAERVARTKAEKQRRDLGEELEALRSELEDTLDST
NAQQELR---SKREQEVTELKKTLEEETRIHEVAVQELRQRHGQALGELAEQLEQARRG-
--KGAWEKTRLALEAEVSELRVELSSLQTARQEGEQRRRRLESQLQ--------------
------------------EVQG------RAGDGERARAE---------------------
-AAEKLQRAQAELENVSGALNEAESKAIRLSKELSSTEAQLHDAQELLQEETRAKLALGS
RVRAMEAE-------------------------------AAGLREQLEEEAAARERAGRE
----------LQTTQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQ-----RLAE
KTETVD---RLERGRRR-----------LQQELDDA------------------TMDLE-
---QQRQLVSTLEKKQRKFDQLL----------AEEKAAVLRAVEERERAEAEGREREAR
ALSLTRALEEEQEAREE-----------------------LERQNRALRAELEALLSSKD
DVGKSVHELERACRVA--------EQAAN-DLRAQVTELED----ELTAA-EDAKLRLEV
TV---QALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEE-RKQRTLAVAARK-KL
EGELEELKAQMAS-----------A-GQGKEEAVKQL---RK------------------
-MQA-QMKELWREVEETRSS-REEIF-SQNRESEKRLKGLEAEVLRLQEELAASDRARRQ
AQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQ
VESLTT---------ELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARAR--HKM
TIAALESKLAQAEEQLEQET----------------------------------------
----------RERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKR
QLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLR---------------
------------------------------------RGPLTFTTRTVRQVFRLEEGVASD
EE--TEEAEPGSGPS-PEPEGSPPAHPQ--

MAAVTMSVPGRKAPPRPGPVPEAAQPFLFTPQGPGGGS----------GPPQVEWTA

PF02736 // ENSGT00760000118919_8_Domain_0 (58, 102)

RRM
VW--VPSELHGFEAAALRDEGEEEAEVELAESGRRLRLPRD

ENSGT00760000118919_8_Linker_0_1 (102, 114)

QIQRMNPPKFSK

PF00063 // ENSGT00760000118919_8_Domain_1 (114, 982)

AEDMAEL
TCLNEASVLHNLRERYYSGLIYTYSGLFCVVINPYKQLPIYTEAIIEMYRGKKRHEVPPH
VYAVTEGAYRSMLQDR-EDQSILCTGESGAGKTENTKK--V---IQ-------YLAHVAS
SPKGRKEP-------GVP-------------------------ASY----PTPWQGELER
QLLQANPILEAFGNAKTVKNDNSS-RFGK------FIRINFDVAGYIVGANI--ETYLLE
KSRAIRQAKDECSFHI----FYQLLGGAG--EQLQADLLLEPFSHYRFLTNGPSSSPGQE
RE-LLQETLESLRVLGFTHEEITSMLRVVSAVLQFGNIVLKKERNTDQATMPDNTAAQKL
CRLLGLGVTDFSRALLAPRIK-VGRDYV----QKAQTKEQADFALEALAKATYERLFRWL
VLRLNRALDRSPRQGASFLGILDIAGFEIFQLNSFEQLCINY-TNEKLQQLFNHTMFVL-
-EQEEYQREGIPWTFLDFGLDLQPCIDLIER-------------PANPPGLLALLDEECW
FPKATDK-SFVEKVAQEQGGHPKFQRPRQLRDQADFSVLHYAGKVDYKANEWLMKNMDPL
NDNVAALLHQSTDRLTAEIWKD--------------------------------------
------------VEGIVGLEQVNSLGDG-P-P-GGRPRRGMFRTVGQLYKESLSRLMATL
SNTNPSFVRCIIPNHEKRAGKLEPR---------LVL-----DQLRCNGVLEGIRICRQG
FPNRI-------------------LF--QEFRQRYEILTPNA---IPKGFMDGKQACEKM
IQALELDPNL-YRVGQSKIFF

ENSGT00760000118919_8_Linker_1_12 (982, 998)

RAGVLAQLEEERDLKV

PF00612 // ENSGT00760000118919_8_Domain_12 (998, 1020)

TDIIVSFQAAARG--YLARRAFQ
K-RQQQQSALRVMQRNCAAYLKLRHWQWWR-----------------LFTKV--KPLLQV
TR--QDEVLQARAQELQKVQELQQQSARQVGELQDRLAQLEEERTRLAEQLRAEAELCSE
A---EEMRGRLAARKQ-ELELVVTEL----ETR-------VGEEEECSRQLQTEKKRLQQ
HIQELETHL------------EAEEGARQKLQLEKVTTEAKLKKFQE-DLLHLE---DQN
AKLGKERKLLEERLAEFSSQATE--------EEEKVKSLNKLRLKYEATIADMEDRLRKE
EKGRQELEKLKRRMDGESSE-LQEQMV

PF01576 // ENSGT00760000118919_8_Domain_13 (1348, 2557)

EHKQRAEE-LRVQLDR--KEEELQAALARAVEE
GGARAQLLKSLREAQAGLAESQEDLEAERAARAKAEKQRRDLGEELEALRSELEDTLDST
NAQQELR---SKREQEVTELKKALEEETRTHEVAVQELRQRHGQALGELAEQLEQARRG-
--KSVWEKTRMSLEAEVSELRAELSSLQSTRQESEQRRRRLESQLQ--------------
------------------EVQG------RAGDGERARVE---------------------
-AAEKLQRAQAELENVSGALSEAESRAIRLSKELSSTEVQLHDAQELLQEETRAKLALGS
RVRALESE-------------------------------ATGLREQLEEEAAARERAGRE
----------LQAAQAQLSEWRRRQEEEAGALEAGEEARRRVAREAEALTQ-----RLAE
KTEAVE---RLDRGRRR-----------LQQELDDA------------------TMDLE-
---QQRQLVSTLEKKQRKFDQLL----------AEEKAAVLRVVEERERVEAEGREREAR
ALALTRALEEEQEAREE-----------------------LERQNRALRAEMEALLSSKD
DVGKSVHELERARRVA--------EQAAS-DLRTQVTELED----ELTAA-EDAKLRLEV
TM---QALKAQHERDLQGHDEAGEERRRQLAKQLRDAEVERDEE-RKQRALAVATRK-KL
EAELEELKAQMET-----------A-GQGKEEAVKQL---RK------------------
-MQT-QMKELWREVEESRTS-REEIF-VQNRESEKRLKGLEAEVLRLQEELAASDRARRQ
AQQERDEMADEVASGNLGKAAILEEKRQLEGRLGQMEEELEEEQSNAELVNDRYRKLLLQ
VETMTT---------ELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARAR--QKM
VIAALESKLAQAEEQLEHES----------------------------------------
----------RERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRLKQLKR
QLEEAEDEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLR---------------
------------------------------------RGPLTFTTRTVRQVFHLEEGVASD
EE--AEEAEPGAGAPHPESDGPVQAPPQ--

MAAVRLSVPGRKAPPKPGPE----------------------------------------
------------------------AEVELAESGRRLWLPRDQVQRMNPPKFSKA

PF00063 // ENSGT00760000118919_8_Domain_1 (115, 646)

EDMAEL
TCLNEASVLHNLRERYYSGLIYTYSGLFCVVINPYKQLPIYTEAIVEMYRGKKRHEVPPH
VYAVTEGAYRSMLQGD---------GESGAGKTENTKK--V---IQ-------YLAHVAS
SPKGRKEPGVPVSHLLGS------------------------------------------
------PRPAAASAAGRLRSDPSQ-QC-----------------------GRLRVPYLLE
KSRAIRQAKDECSFHI----FYQLLGGAG--EQLKADLLLEPSSHYRFLTNGPSSTPSQE
RE-LFQETLEALRVLGFAPEEITSMLRMVSAVLQFGNVVLKSF------QDPGISSAQKL
CRLLGLGVTDFSRALLTPRIK-VGRDYV----QKAQTKEQADFALEALAKATYERLFRWL
VLRLNRALDRSPRQGASFLGILDI------------------------------------
---------------------------------------------ANPPGLLALLDEECW
FPKATDK-SFVEKVAQEQGGHPKFQRPRQLRDQADFSVLHYAGKVDYKANEWLMKNMDPL
NDNVAALLHQSTDRMTAEIWKDEHGDLPQASFLGSFP---------LLSPGSAGRCCSAS
SPPGGGCLCG-NVESIVGLEQVSSLGDG-P-L-GGRPRRGMFRTVGQLYKESLSRLMATL
SNTNPSFVRCIVPNHEKRAGKLEPR---------LVL-----DQLRCNGVLEGIRICRQG
FPNRI-------------------LF--QEFRQRYEILTPNA---IPKGFMDGKQACEKM
IQALELDPNL-YRVGQSKIFFRAGVLAQLEEERDLKVTDIIVSFQAAARG--YLARRAFQ
R-RQQQQSALRVMQRNCAAYLKLRHWQWWR-----------------LFTKV--KPLLQV
TR-

PF01576 // ENSGT00760000118919_8_Domain_14 (1084, 1581)

-QDEVLQARAQELQK---------------------LEEERARLAEQLRAEAELCAE
A---EETRGRLASRKQ-ELELVVTEM----EAR-------MGEEEESSRQLQAEKRRLQL
HIQELETHL------------EAEEGARQKLQMEQVTTEAKLKKFEE-DLLLLE---DRN
ARLGKERRLLEERLAEFSSQAAE--------EEEKIKSLSKLRLKYEATIADMEGERH--
---------------PGSSE-LQEQMAEQQQRAEE-LRAQLGR--KEEELQMALARAEEE
GGARAQLLKSLREAQAGPKFDPQY-------------KKKELNTSLEQARK---GAI---
---TSSPVSQTKREQEVTELKKTLEEETRVHEVAVQELRQRHGQALGELTEQLEQARRG-
--KGAWEKMRLALEAEVSELRAELSSLQTSRQEGEQRRRRLESQLQ--------------
------------------EVTR------PRGFAALGYVL---------------------
-L------------SESSCL-------------------SLQECRDYLPEP---------
----PQPAE------------------------------ATGLREQIEEEAAARERAGRE
----------LQTAQVQVGPRRP-------------------------------------
--------SRLERGRHR-----------LQQELDDT------------------TVDLE-
---QQRQLVSSLEKKQRKFDQLL----------AEEKAAVLRAVEERERVEAEGREREAR
ALSLTRALEEEQEARLE-----------------------LERQNRALRAEMEALLSSKD
DVGKSVHELERARRVA--------EQAAS-DLRAQVTELED----ELTAA-EDAKLRLEV
TV---QALKAQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEE-RKQRALAVAARK-KL
EAELEELKAQTAA-----------A-GQGKEEAVKQL---RK------------------
-MQVRRRSVLWKEIEQTGESVRP--------ESPW-LPSPWGPPAAVPQELAASDRGRRQ
AQQDRDEMADELANGSLSKAALQEEKRQLEGRLGQLEEELEEEQSNAELLNDRYRKLLLQ
VETLTT---------ELCAERSFSAKAESGRQQLERQIQELRGHLGEEDAGARAR--QKM
TIATLESKLAQAEEQLEQEA----------------------------------------
----------RERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRAKQLKR
QLE---------------------------------------------------------
------------------------------------------------------------
------------------------------

MAAVTMSVPGRKVPPRPGPVPEAAQPFLFTPRGPSTGG----GPGGSGTSPQVEWTA

PF02736 // ENSGT00760000118919_8_Domain_0 (58, 102)

RRL
VW--VPSELHGFEAAALRDEGEEEAEVELAESGRRLRLPRD

ENSGT00760000118919_8_Linker_0_1 (102, 115)

QIQRMNPPKFSKA

PF00063 // ENSGT00760000118919_8_Domain_1 (115, 982)

EDMAEL
TCLNEASVLHNLRERYYSGLIYTYSGLFCVVINPYKQLPIYTEAIVEMYRGKKRHEVPPH
VYAVTEGAYRSMLQDR-EDQSILCTGESGAGKTENTKK--V---IQ-------YLAHVAS
SPKGRKEP-------GVP-----------------------------ASTSTMSYGELER
QLLQANPVLEAFGNAKTVKNDNSS-RFGK------FIRINFDVAGYIVGANI--ETYLLE
KSRAIRQAKDECSFHI----FYQLLGGAG--EQLKADLLLEPSSHYRFLTNGPSSSPSQE
RE-LFQETLESLRVLGFTHEEITSMLRMVSAVLQFGNIVLKRERNTDQATMPDNTAAQKL
CRLLGLGVTDFSRALLTPRIK-VGRDYV----QKAQTKEQADFALEALAKATYERLFRWL
VLRLNRALDRSPRQGASFLGILDIAGFEIFQLNSFEQLCINY-TNEKLQQLFNHTMFVL-
-EQEEYQREGIPWTFLDFGLDLQPCIDLIER-------------PANPPGLLALLDEECW
FPKATDK-SFVEKVAQEQGGHPKFQRPRHLRDQADFSVLHYAGKVDYKANEWLMKNMGPL
NDNVAALLHQSTD------------------------------------------RL---
-TAEI----WKDVEGIVGLEQVSSLGEG-P-P-GGRPRRGMFRTVGQLYKESLSRLMATL
SNTNPSFVRCIVPNHEKRAGKLEPR---------LVL-----DQLRCNGVLEGIRICRQG
FPNRI-------------------LF--QEFRQRYEILTPNA---IPKGFMDGKQACEKM
IQALELDPNL-YRVGQSKIFFRAGVLAQLEEERDLKVTDIIVSFQAAARG--YLARRAFQ
K-RQQQQSALRVMQRNCAAYLKLRHWQWWR-----------------LFTKV--KPLLQV
TR--QDEVLQARAQELQKVQELQQQSAREVGELQGRVTQLEEERTRLTEQLRAEAELCAE
A---EETRERLAARKQ-ELELVVSEL----EAR-------VGEEEECSRQLQTEKKRLQQ
HIQELESHL------------EAEEGARQKLQLEKVTTEAKLKKFEE-DLLLLE---DQN
AKLGKERRLLEERLAEFSSQAAE--------EEEKVKSLNKLRLKYEATIADMEDRLRKE
EKGRQELEKLKRRLDGESSE-LQEQMVEQ

PF01576 // ENSGT00760000118919_8_Domain_13 (1350, 2557)

QQRVEE-LRAQLGR--KEDELQAALARAEDE
GGARAHMLKSLREAQAALAEAQEDLEAERVARAKAEKQRRDLGEELEALRGELEDTLDST
NAQQELRK-RSKREQEVTELKKALEDETRIHEAAVQELRQRHGQALGELAEQLEQARRG-
--KGAWEKTRLALEAEVSELRAELSSLQSARQEGEQRRRRLESQLQ--------------
------------------EVQG------RAGDGERARVE---------------------
-AAEKLQRAQAELENVSGALSEAESKAIRLSKELSSTEAQLHDAQELMQEETRAKLALGS
RVRALEAE-------------------------------AAGLREQLEEEATARERVGRE
----------LQAAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEVLTQ-----RLAE
KTETVD---RLERGRRR-----------LQQELDDA------------------TMDLE-
---QQRQLVSTLEKKQRKFDQLL----------AEEKAAVLRAVEERERVEAEGREREAR
ALSLTRALEEEQEAREE-----------------------LERQNRALRAELEALLSNKD
DVGKSVHELERARRVA--------EQAAN-DLRTQVTELED----ELTAA-EDAKLRLEV
TV---QALKTQHERDLQGRDEAGEERRRQLAKQLRDAELERDEE-RKQRALAVAARK-KL
EAELEELKAQMAA-----------A-GQGKEEAVKQL---RK------------------
-MQA-QMKELWREVEESRSS-REEIF-TQNRENEKRLKGLEEEVLRLQEELAASDRARRQ
AQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNAELLNDRYRKLLLQ
VESLTT---------ELSAERSFSAKAESGRQQLERQVQELRGRLGEEDAGARAR--QKM
IIAALESKLAQAEEQLEQES----------------------------------------
----------RERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQMEKGNLRVKQLKR
QLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLR---------------
------------------------------------RGPLTFTTRTVRQVFRLEEGVASD
EE--AEEAEPGSGPPALEPEGSPPAQPQ--

MAAMTMSVPGRKAPPRPGPVPEAAQPFLFTPRGPSAGG----GPG-SGTSPQVEWTAR

PF02736 // ENSGT00760000118919_8_Domain_0 (59, 98)

RL
VW--VPSELHGFEAAALRDEGEEEAEVELAESGRRLR

ENSGT00760000118919_8_Linker_0_1 (98, 115)

LPRDQIQRMNPPKFSKA

PF00063 // ENSGT00760000118919_8_Domain_1 (115, 982)

EDMAEL
TCLNEASVLHNLRERYYSGLIYTYSGLFCVVINPYKQLPIYTEAIVEMYRGKKRHEVPPH
VYAVTEGAYRSMLQGD---------GESGAGKTENTKK--V---IQ-------YLAHVAS
SPKGRK-----E-----------------------------------PGV----PGELER
QLLQANPILEAFGNAKTVKNDNSS-RFGK------FIRINFDVAGYIVGANI--ETYLLE
KSRAIRQAKDECSFHI----FYQLLGGAG--EQLKADLLLEPCSQYRFLTNGPSSSPGQE
RE-LFQETLESLRVLGFTHEEIISMLRMVSAVLQFGNIALKRERNTDQATMPDNTAAQKL
CRLLGLGVTDFSRALLTPRIK-VGRDYV----QKAQTKEQADFALEALAKATYERLFRWL
VLRLNRALDRSPRQGASFLGILDIAGFEIFQLNSFEQLCINY-TNEKLQQLFNHTMFVL-
-EQEEYQREGIPWTFLDFGLDLQPCIDLIER-------------PANPPGLLALLDEECW
FPKATDK-SFVEKVAQEQGGHPKFQRPRQLRDQADFSVLHYAGKVDYKANEWLMKNMDPL
NDSVAALLHQSTDRLTAEIWKDEHGGFQQFSFLGSFP---------PSPPGSAERCSSAI
SPPGGGCLCASMVEGIVGLEQVSSLGDG-P-P-GGRPRRGMFRTVGQLYKESLSRLMATL
SNTNPSFVRCIVPNHEKRAGKLEPR---------LVL-----DQLRCNGVLEGIRICRQG
FPNRI-------------------LF--QEFRQRYEILTPNA---IPKGFMDGKQACEKM
IQALELDPNL-YRVGQSKIFFRAGVLAQLEEERDLKVTDIIVSFQAAARG--YLARRAFQ
K-RQQQQSALRVMQRNCAAYLKLRHWQWWR-----------------LFTKV--KPLLQV

PF01576 // ENSGT00760000118919_8_Domain_13 (1081, 2504)

TR--QDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERTRLAEQLRAEAELCAE
A---EETRGRLAARKQ-ELELVVSEL----EAR-------VGEEEECSRQLQTEKKRLQQ
HIQELEAHL------------EAEEGARQKLQLEKVTTEAKMKKFEE-DLLLLE---DQN
SKLSKERKLLEDRLSEFSSQAAE--------EEEKVKSLNKLRLKYEATIADMEDRLRKE
EKGRQELEKLKRRLDGESSE-LQEQMVEQQQRAEE-LRAQLGR--KEEELQAALARAEDE
GGARAQLLKSLREAQAALAEAQEDLEAERVARTKAEKQRRDLGEELEALRSELEDTLDST
NAQQELR---SKREQEVTELKKTLEEETRIHEVAVQELRQRHGQALGELAEQLEQARRG-
--KGAWEKTRLALEAEVSELRVELSSLQTARQEGEQRRRRLESQLQ--------------
------------------EVQG------RAGDGERARAE---------------------
-AAEKLQRAQAELENVSGALNEAESKAIRLSKELSSTEAQLHDAQELLQEETRAKLALGS
RVRAMEAE-------------------------------AAGLREQLEEEAAARERAGRE
----------LQTTQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQ-----RLAE
KTETVD---RLERGRRR-----------LQQELDDA------------------TMDLE-
---QQRQLVSTLEKKQRKFDQLL----------AEEKAAVLRAVEERERAEAEGREREAR
ALSLTRALEEEQEAREE-----------------------LERQNRALRAELEALLSSKD
DVGKSVHELERACRVA--------EQAAN-DLRAQVTELED----ELTAA-EDAKLRLEV
TV---QALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEE-RKQRTLAVAARK-KL
EGELEELKAQMAS-----------A-GQGKEEAVKQL---RK------------------
-MQA-QMKELWREVEETRSS-REEIF-SQNRESEKRLKGLEAEVLRLQEELAASDRARRQ
AQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQ
VESLTT---------ELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARAR--HKM
TIAALESKLAQAEEQLEQET----------------------------------------
----------RERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKR
QLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLR---------------
------------------------------------RGPLTFTTRTVRQVFRLEEGVASD
EE--TEEAEPGSGPS-PEPEGSPPAHPQ--

MAAATMSVSGRKVASRPGPVPEAAQSFLFAPRTPNVGG----PG-----GPQVEWTAR

PF02736 // ENSGT00760000118919_8_Domain_0 (59, 98)

RM
VW--VPSELHGFEAAALRDEGEEEAEVELAESGRRLR

ENSGT00760000118919_8_Linker_0_1 (98, 115)

LPRDQIQRMNPPKFSKA

PF00063 // ENSGT00760000118919_8_Domain_1 (115, 982)

EDMAEL
TCLNEASVLHNLRERYYSGLIYTYSGLFCVVINPYKQLPIYTEAIVEMYRGKKRHEVPPH
VYAVTEGAYRSMLQDR-EDQSILCTGESGAGKTENTKK--V---IQ-------YLAHVAS
SPKGRKEPGVPVSHTALGHSRHV------------------TSSIFYFGLHSTFTGELER
QLLQANPILEAFGNAKTVKNDNSS-RFGK------FIRINFDIAGYIVGANI--ETYLLE
KSRAIRQAKDECSFHI----FYQLLGGAG--EQLKADLLLEPYSHYRFLTNGPSSSPGQE
RE-LFQETLESLRVLGLLPEEITAMLRTVSAVLQFGNIVLKKERNTDQATMPDNTAAQKL
CRLLGLGVTDFSRALLTPRIK-VGRDYV----QKAQTKEQADFALEALAKATYERLFRWL
VLRLNRALDRSPRQGASFLGILDIAGFEIFQLNSFEQLCINY-TNEKLQQLFNHTMFVL-
-EQEEYQREGIPWTFLDFGLDLQPCIDLIER-------------PANPPGLLALLDEECW
FPKATDK-SFVEKVAQEQGSHPKFQRPRNLRDQADFSVLHYAGKVDYKASEWLMKNMDPL
NDNVAALLHQSTDRLTAEIWK---------------------------------------
-----------DVEGIVGLEQVSSLGDG-P-P-GGRPRRGMFRTVGQLYKESLSRLMATL
SNTNPSFVRCIVPNHEKRAGKLEPR---------LVL-----DQLRCNGVLEGIRICRQG
FPNRI-------------------LF--QEFRQRYEILTPNA---IPKGFMDGKQACEKM
IQALELDPNL-YRVGQSKIFFRAGVLAQLEEERDLKVTDIIVSFQAAARG--YLARRAFQ
R-RQQQQSALRVMQRNCAAYLKLRNWQWWR-----------------LFIKV--KPLLQV

PF01576 // ENSGT00760000118919_8_Domain_13 (1081, 2504)

TR--QDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERMRLAEQLRAEAELCSE
A---EETRARLAARKQ-ELELVVTEL----EAR-------VGEEEECSRQLQSEKKRLQQ
HIQELESHL------------EAEEGARQKLQLEKVTTEAKMKKFEE-DLLLLE---DQN
SKLSKERRLLEERLAEFSSQAAE--------EEEKVKSLNKLRLKYEATISDMEDRLKKE
EKGRQELEKLKRRLDGESSE-LQEQMVEQKQRAEE-LLAQLGR--KEDELQAALLRVEEE
GGARAQLLKSLREAQAGLAEAQEDLEAERVARAKAEKQRRDLGEELEALRGELEDTLDST
NAQQELR---SKREQEVTELKKALEEESHAHEVSMQELRQRHSQALVEMAEQLEQARRG-
--KGVWEKTRLSLEAEVSELKAELSSLQTSRQEGEQKRRRLESQLQ--------------
------------------EVQG------RSSDSERARSE---------------------
-AAEKLQRAQAELESVSTALSEAESKAIRLGKELSSAESQLHDTQELLQEETRAKLALGS
RVRALEAE-------------------------------AAGLREQMEEEVVARERAGRE
----------LQSTQAQLSEWRRRQEEEAAVLEAGEEARRRAAREAETLTQ-----RLAE
KTEAVE---RLERARRR-----------LQQELDDA------------------TVDLG-
---QQKQLLSTLEKKQRKFDQLL----------AEEKAAVLRAVEDRERIEAEGREREAR
ALSLTRALEEEQEAREE-----------------------LERQNRALRAELEALLSSKD
DVGKNVHELERARKVA--------EQAAS-DLRTQVTELED----ELTAA-EDAKLRLEV
TV---QALKAQHERDLQGRDDAGEERRRQLAKQLRDAEVERDEE-RKQRALAMAARK-KL
ELELEELKAQTSA-----------A-GQGKEEAVKQL---KK------------------
-MQV-QMKELWREVEETRSS-RDEMF-TLSRENEKKLKGLEAEVLRLQEELAASDRARRQ
AQQDRDEMAEEVASGNLSKAATLEEKRQLEGRLSQLEEELEEEQNNSELLKDHYRKLVLQ
VESLTT---------ELSAERSFSAKAESGRQQLERQIQELRARLGEEDAGARAR--QKM
LIAALESKLAQAEEQLEQES----------------------------------------
----------RERILSGKLVRRAEKRLKEVVLQVDEERRVADQVRDQLEKSNLRLKQLKR
QLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLR---------------
------------------------------------RGPLTFTTRTVRQVFRLEEGVASD
EEE-AEGAEPGSAP-GQEPEAPPPATPQ--

MAAMTMSVPGRKAPPRPGPVPEAAQPFLFTPRGPSAGG----GPG-SGTSPQVEWTAR

PF02736 // ENSGT00760000118919_8_Domain_0 (59, 98)

RL
VW--VPSELHGFEAAALRDEGEEEAEVELAESGRRLR

ENSGT00760000118919_8_Linker_0_1 (98, 115)

LPRDQIQRMNPPKFSKA

PF00063 // ENSGT00760000118919_8_Domain_1 (115, 859)

EDMAEL
TCLNEASVLHNLRERYYSGLIYTYSGLFCVVINPYKQLPIYTEAIVEMYRGKKRHEVPPH
VYAVTEGAYRSMLQDR-EDQSILCTGESGAGKTENTKK--V---IQ-------YLAHVAS
SPKAG-----LAWPPAP-------------------------FSLISCIISCAWQGELER
QLLQANPILEAFGNAKTVKNDNSS-RFGK------FIRINFDVAGYIVGANI--ETYLLE
KSRAIRQAKDECSFHI----FYQLLGGAG--EQLKADLLLEPCSRYRFLTNGPSSSPGQE
RE-LFQETLESLRVLGFTHEEIISMLRMVSAVLQFGNIALKRERNTDQATMPDNTAAQKL
CRLLGLGVTDFSRALLTPRIK-VGRDYV----QKAQTKEQADFALEALAKATYERLFRWL
VLRLNRALDRSPRQGASFLGILDIAGFEIFQLNSFEQLCINY-TNEKLQQLFNHTMFVL-
-EQEEYQREGIPWTFLDFGLDLQPCIDLIER-------------PANPPGLLALLDEECW
FPKATDK-SFVEKVAQEQGGHPKFQRPRQLRDQADFSVLHYAGKVDYKANEWLMKNMDPL
NDNVAALLHQSTDRLTAEIWKDEHGGFQQFSFLGSFP---------PSPPGSAERCSSAI
--------SPPGVEGIVGLEQVSSLGDG-P-P-GGRPRRGMFRTVGQLYKESLSRLMATL
SNTNPSFVRCIVPNHEKR

ENSGT00760000118919_8_Linker_1_11 (859, 934)

VSDS---------------------------AWGGRDGCGRG
--------------------------------L

PF00063 // ENSGT00760000118919_8_Domain_11 (934, 982)

RYEILTPNA---IPKGFMDGKQACEKM
IQALELDPNL-YRVGQSKIFFRAGVLAQLEEERDLKVTDIIVSFQAAARG--YLARRWAA
-------TKERLFHRIAAATVHSASWMWRD-----------------P--LV--KPLLQV

PF01576 // ENSGT00760000118919_8_Domain_14 (1081, 1316)

TR--QDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERTRLAEQLRAEAELCAE
A---EETRGRLAARKQ-ELELVVSEL----EAR-------VGEEEECSRQLQTEKKRLQQ
HIQELEAHL------------EAEEGARQKLQLEKVTTEAKMKKFEE-DLLLLE---DQN
SKLSKERKLLEDRLSEFSSQAAE--------EEEKVKSLNKLRLKYEATIADMEGELPPS
QWGAVGVCV------------------------------------CSDGGLQASSMAEDE
GGARAQLLKSLREAQAALAEAQEDLEAERVARTKAEKQRRDLGEELEALRSELEDTLDST
NAQQELR---SKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARR--
-GKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLESQLQ--------------
------------------EVQG------RAGDGERARAE---------------------
-AAEKLQRAQAELENVSGALNEAESKAIRLSKELSSTEAQLHDAQELLQEETRAKLALGS
RVRAMEAE-------------------------------AAGLREQLEEEAAARERAGRE
----------LQTTQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQ-----RLAE
KTETVD---RLERGRRR-----------LQQELDDA------------------TMDLE-
---QQRQLVSTLEKKQRKFDQLL----------AEEKAAVLRAVEERERAEAEGREREAR
ALSLTRALEEEQEAREE-----------------------LERQNRALRAELEALLSSKD
DVGKSVHELERACRVA--------EQAAN-DLRAQVTELED----ELTAA-EDAKLRLEV
TV---QALKTQHERDLQGHDEAGEERRRQLAKQLRDAEVERDEE-RKQRTLAVAARK-KL
EGELEELKAQMAS-----------A-GQGKEEAVKQL---RK------------------
-MQV-RAGRELRGETRA------QIA-----SPH----PHWPPLSLSSQELAASDRARRQ
AQQDRDEMADEVANGNLGKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQ
VESLTT---------ELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARAR--HKM
TIAALESKLAQAEEQLEQET----------------------------------------
----------RERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKR
QLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLR---------------
------------------------------------RGPLTFTTRTVRQVFRLEEGVASD
EE--TEEAEPGSGPS-PEPEGSPPAHPQ--

MAAVTMSVPGRKAPPRPGPVPEAAQPFLFTPRGPSAGG----GPG-SGTSPQVEWTAR

PF02736 // ENSGT00760000118919_8_Domain_0 (59, 98)

RL
VW--VPSELHGFEAAALRDEGEEEAEVELAESGRRLR

ENSGT00760000118919_8_Linker_0_1 (98, 115)

LPRDQIQRMNPPKFSKA

PF00063 // ENSGT00760000118919_8_Domain_1 (115, 982)

EDMAEL
TCLNEASVLHNLRERYYSGLIYTYSGLFCVVINPYKQLPIYTEAIVEMYRGKKRHEVPPH
VYAVTEGAYRSMLQDR-EDQSILCTGESGAGKTENTKK--V---IQ-------YLAHVAS
SPKGRKEP-------GVP-----------------------------ASVSTVSYGELER
QLLQANPILEAFGNAKTVKNDNSS-RFGK------FIRINFDVAGYIVGANI--ETYLLE
KSRAIRQAKDECSFHI----FYQLLGGAG--EQLKADLLLEPCSQYRFLTNGPSSSPGQE
RE-LFQETLESLRVLGFTHEEIISMLRMVSAVLQFGNIALKRERNTDQATMPDNTAAQKL
CRLLGLGVTDFSRALLTPRIK-VGRDYV----QKAQTKEQADFALEALAKATYERLFRWL
VLRLNRALDRSPRQGASFLGILDIAGFEIFQLNSFEQLCINY-TNEKLQQLFNHTMFVL-
-EQEEYQREGIPWTFLDFGLDLQPCIDLIER-------------PANPPGLLALLDEECW
FPKATDK-SFVEKVAQEQGGHPKFQRPRQLRDQADFSVLHYAGKVDYKANEWLMKNMDPL
NDNVAALLHQSTDRLTAEIWKDEHGGFQQFSFLGSFPPSPPGSAERCSSAVSPPGV----
-------------EGIVGLEQVSSLGDG-P-P-GGRPRRGMFRTVGQLYKESLSRLMATL
SNTNPSFVRCIVPNHEKRAGKLEPR---------LVL-----DQLRCNGVLEGIRICRQG
FPNRI-------------------LF--QEFRQRYEILTPNA---IPKGFMDGKQACEKM
IQALELDPNL-YRVGQSKIFFRAGVLAQLEEERDLKVTDIIVSFQAAARG--YLARRAFQ
K-RQQQQSALRVMQRNCAAYLKLRHWQWWR-----------------LFTKV--KPLLQV

PF01576 // ENSGT00760000118919_8_Domain_13 (1081, 2504)

TR--QDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERTRLAEQLRAEAELCAE
A---EETRGRLAARKQ-ELELVVSEL----EAR-------VGEEEECSRQLQTEKKRLQQ
HIQELEAHL------------EAEEGARQKLQLEKVTTEAKMKKFEE-DLLLLE---DQN
SKLSKERKLLEDRLSEFSSQAAE--------EEEKVKSLNKLRLKYEATIADMEDRLRKE
EKGRQELEKLKRRLDGESSE-LQEQMVEQQQRAEE-LRAQLGR--KEEELQAALARAEDE
GGARAQLLKSLREAQAALAEAQEDLEAERVARTKAEKQRRDLGEELEALRSELEDTLDST
NAQQELR---SKREQEVTALKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRG-
--KGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLESQLQ--------------
------------------EVQG------RAGDGERARAE---------------------
-AAEKLQRAQAELENVSGALNEAESKAIRLSKELSSTEAQLHDAQELLQEETRAKLALGS
RVRAMEAE-------------------------------AAGLREQLEEEAAARERAGRE
----------LQTTQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQ-----RLAE
KTETVD---RLERGRRR-----------LQQELDDA------------------TMDLE-
---QQRQLVSTLEKKQRKFDQLL----------AEEKAAVLRAVEERERAEAEGREREAR
ALSLTRALEEEQEAREE-----------------------LERQNRALRAELEALLSSKD
DVGKSVHELERACRVA--------EQAAN-DLRAQVTELED----ELTAA-EDAKLRLEV
TV---QALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEE-RKQRTLAVAARK-KL
EGELEELKAQMAS-----------A-GQGKEEAVKQL---RK------------------
-MQA-QMKELWREVEETRSS-REEIF-SQNRESEKRLKGLEAEVLRLQEELAASDRARRQ
AAQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQ
VESLTT---------ELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARAR--HKM
TIAALESKLAQAEEQLEQET----------------------------------------
----------RERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKR
QLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLR---------------
------------------------------------RGPLTFTTRTVRQVFRLEEGVASD
EE--TEEAEPGSGPS-PEPEGSPPAHPQ--

MAAVTMSVPGRKAPPRPGPVPEAAQPFLFTPRGPSAGG----GPG-SGTSPQVEWTA

PF02736 // ENSGT00760000118919_8_Domain_0 (58, 102)

RRL
VW--VPSELHGFEAAALRDEGEEEAEVELAESGRRLRLPRD

ENSGT00760000118919_8_Linker_0_3 (102, 115)

QIQRMNPPKFSKA

PF00063 // ENSGT00760000118919_8_Domain_3 (115, 195)

EDMAEL
TCLNEASVLHNLRERYYSGLIYTYSGLFCVVINPYKQLPIYTEAIVEMYRGKKRHEVPPH
VYAVTEGAYRSMLQ

ENSGT00760000118919_8_Linker_3_1 (195, 358)

D---------------------------------------------
------------------------------------------------------------
---------------------------------------------------------

PF00063 // ENSGT00760000118919_8_Domain_1 (358, 982)

LLE
KSRAIRQAKDECSFHI----FYQLLGGAG--EQLKADLLLEPCSHYRFLTNGPSSSPGQE
RE-LFQETLESLRVLGFTHEEIISMLRMVSAVLQFGNIALKRERNTDQATMPDNTAAQKL
CRLLGLGVTDFSRALLTPRIK-VGRDYV----QKAQTKEQADFALEALAKATYERLFRWL
VLRLNRALDRSPRQGASFLGILDIAGFEIFQLNSFEQLCINY-TNEKLQQLFNHTMFVL-
-EQEEYQREGIPWTFLDFGLDLQPCIDLIER-------------PANPPGLLALLDEECW
FPKATDK-SFVEKVAQEQGSHPKFQRPRHLRDQADFSVLHYAGKVDYKANEWLMKNMDPL
NDSVAALLHQSTDRLTAEIWKDEHGGFQQFSFLGSFP---------PSPPGSAERCSSAM
SPPG--------VEGIVGLEQVSSLGDG-P-P-GGRPRRGMFRTVGQLYKESLSRLMATL
SNTNPSFVRCIVPNHEKRAGKLEPR---------LVL-----DQLRCNGVLEGIRICRQG
FPNRI-------------------LF--QEFRQRYEILTPNA---IPKGFMDGKQACEKM
IQALELDPNL-YRVGQSKIFFRAGVLAQLEEERDLKVTDIIVSFQAAARG--YLARRAFQ
K-RQQQQSALRVMQRNCAAYLKLRHWQWWR-----------------LFTKV--KPLLQV
TR--QDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAE
A---EETRGRLAARKQ-ELELVVSEL----EAR-------VGEEEECSRQMQTEKKRLQQ
HIQELEAHL------------EAEEGARQKLQLEKVTTEAKMKKFEE-DLLLLE---DQN
SKLSKERKLLEDRLAEFSSQAAE--------EEEKVKSLNKLRLKYEATIADMEDRLRKE
EKGRQELEKLKRRLDGESSE-LQEQMVEQQQRAEE-LRAQLGR--KEEELQAALARAEDE
GGARAQLLKSLREAQAALAEAQEDLESERLARTKAEKQRRDLGEELEALRGELEDTLDST
NAQQELR---SKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRG-
--KGAWEKTRLALEAEVSELRAELSSLQTARQESEQRRRRLESQLQ--------------
------------------EVQG------RAGDGERARAE---------------------
-AAEKLQRAQAELDNVSGALNEAESKTIRLSKELSSIEAQLHDAQELLQEETRAKLALGS
RVRAMEAE-------------------------------AAGLREQLEEEAAARERAGRE
----------LQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQ-----RLAE
KTETVD---RLERGRRR-----------LQQELDDA------------------TMDLE-
---QQRQLVSTLEKKQRKFDQLL----------AEEKAAVLRAVEERERAEAEGREREAR
ALSLTRALEEEQEAREE-----------------------LERQNRALRAELEALLSSKD
DVGKSVHELERACRVA--------EQAAN-DLRAQVTELED----ELTAA-EDAKLRLEV
TV---QALKTQHERDLQGHDEAGEERRRQLAKQLRDAEVERDEE-RKQRTLAVAARK-KL
EGELEELKAQMAS-----------A-GQGKEEAVKQL---RK------------------
-MQ----------------------------------------------

PF01576 // ENSGT00760000118919_8_Domain_17 (2210, 2557)

ELAASDRARRQ
AQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQ
VESLTT---------ELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARAR--HKM
TIAALESKLAQAEEQLEQET----------------------------------------
----------RERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKR
QLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLR---------------
------------------------------------RGPLTFTTRTVRQVFRLEEGVASD
EE--AEEAQPGSGPS-PEPEGSPPAHPQ--

MATVTLSVLXXXXXXRPGPVPEAAQPYLFALNTPGVGG----GPGGSGASPQVEWTA

PF02736 // ENSGT00760000118919_8_Domain_0 (58, 102)

RRL
VW--VPSELHGFEAAALRDEGEEEAEVELAESGRRLRLPRD

ENSGT00760000118919_8_Linker_0_1 (102, 114)

QIQRMNPPKFSK

PF00063 // ENSGT00760000118919_8_Domain_1 (114, 982)

AEDMAEL
TCLNEASVLHNLRERYYSGLIYTYSGLFCVVINPYKQLPIYTEAIVEMYRGKKRHEVPPH
VYAVTEGAYRSMLQDR-EDQSILCTGESGAGKTENTKK--V---IQ-------YLAHVAS
SPKGRKEPGVP--------------------------------------------GELER
QLLQANPILEAFGNAKTVKNDNSS-RFGK------FIRINFDVAGYIVGANI--ETYLLE
KSRAIRQAKDECSFHI----FYQLLGGAG--EQLKADLLLEPYSHYRFLTNGPSSSPGQE
RE-LFQETLESLRVLGFSHEEITSMLRMVSAVLQFGNVVLKQERNTDQATMPDNTAAQKL
CRLLGLGVTDFSRALLTPRIK-VGRDYV----QKAQTKEQADFALEALAKATYERLFRWL
VLRLNRALDRSPRQGASFLGILDIAGFEIFQLNSFEQLCINY-TNEKLQQLFNHTMFVL-
-EQEEYQREGIPWTFLDFGLDLQPCIDLIER-------------PANPPGLLALLDEECW
FPKATDK-SFVEKVAQEQGSHPKFQRPRQLRDQADFSVLHYAGKVDYKANEWLMKNMDPL
NDNVAGLLHQSTDRMTAEIWKDAHGAFQPLSLLGAFP---------PAPPGA--------
--------APAGVEGIVGLEQVSSLGDG-P-P-GGRPRRGMFRTVGQLYKESLSRLMATL
SNTNPSFVRCIVPNHEKRSGKLEPK---------LVL-----DQLRCNGVLEGIRICRQG
FPNRI-------------------LF--QEFRQRYEILTPNA---IPKGFMDGKQACEKM
IQALELDPNL-YRVGQSKIFF

ENSGT00760000118919_8_Linker_1_12 (982, 998)

RAGVLAQLEEERDLKV

PF00612 // ENSGT00760000118919_8_Domain_12 (998, 1020)

TDIIVSFQAAARG--YLARRAFQ
K-RQQQQSALRVMQRNCAAYLKLRHWQWWR-----------------LFIKV--KPLLQV
TR--QDEVLQARAQELQKVQELQQQSAREVGELQVRVAQLEEERTRLAEQLRAEAELCAE
A---EETRGRLATRKQ-ELELVVAEL----EAR-------VGEEEECSRQLQTEKRRLQQ
HIQELETHL------------EAEEGARQKLQLEKVTTEARLKKFEE-DLVLLE---DQN
TKLSKXXXXXXXXXXXXXXXXXX--------XXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXX-XXXXXXX--XXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXX
XXXXXXX---XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
X-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--------------
------------------XXXX------

PF01576 // ENSGT00760000118919_8_Domain_13 (1589, 2557)

XXXXXXXXXXX---------------------
-XXXXXXXXXAELETMSGALSEAESKAIRLGKELSSTEAQLHDAQELMQEETRAKLALGS
RVRAE--AE------------------------------AAGLREQLEEEVAAREVA-RE
----------LQAAQVQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-----XXXX
XXXXXX---XXXXXXXX-----------XXXXXXXX------------------XXXXX-
---XXXXXXXXXXXXXXXXXXLL----------AEEKAAVLRVVEERERVEAEGREREAR
ALALTRALEEEQEAREE-----------------------LERQNRALRAELEALLSSKD
DVGQSVHELERARRMA--------EQATN-DLRTQVTELED----ELTAA-EDAKLRLEV
TV---QALKXXXXXXXXXXXXXXXXXXXXXXXXLRDAEVERDEE-RKQRALAVAARK-KL
EAELEELKAQTES-----------A-GQGKEEAVKQL---RK------------------
-MQT-QMKELWREVEETRTS-REEIF-VQSRESEKRLKWLEAEVLRLQEELAASDRARRQ
AQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSSAELLNDRYRKLVLQ
VETLTT---------ELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARAR--QKM
VIAALESKLAQAEEQLEQES----------------------------------------
----------RERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKR
QLEEAEEEASRAHAGRRRLQRELEDVTESAESMNREVTTLRNRLR---------------
------------------------------------RGPLTFTTRTVRQVFRLKEGVVSD
EE--AEEAEPGSGQPGPESEGPLPAQPQ--

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----

PF01576 // ENSGT00760000118919_8_Domain_13 (1685, 2322)

MEAE-------------------------------AAGLREQLEEEAAARERAGRE
----------LQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQ-----RLAE
KTETVD---RLERGRRR-----------LQQELDDA------------------TVDLE-
---QQRQLVSTLEKKQRKFDQLL----------AEEKAAVLRAVEERERAEAEGREREAR
ALSLTRALEEEQEAREE-----------------------LERQNRALRAELEALLSSKD
DVGKSVHELERACRVA--------EQAAN-DLRAQVTELED----ELTAA-EDAKLRLEV
TV---QALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEE-RKQRTLAVAARK-KL
EGELEELKAQLVS-----------S-GQGKEEAVKQL---RK------------------
-MQA-QMKELWREVEESRSS-REEIF-AQNRESDKRLKGLEAEVLRLQEELAASDRARRQ
AQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLPYL
GQ-LTQ---------DCSYGR----------VKV------L

ENSGT00760000118919_8_Linker_13_18 (2322, 2411)

RARKSAKDSSRPALGAGTI
IL----GGTPPLRLLLLPVC----------------------------------------
----------

PF01576 // ENSGT00760000118919_8_Domain_18 (2411, 2504)

RERILSGKLVRRAEKRLKEVVLQVEEERRGADQLRDQLEKGNLRVKQLKR
QLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLR---------------
------------------------------------RGPLTFTTRTVRQVFRLEEGVASD
EE--AEEAEPGSGPS-PEPEGSPSAHPQ--

MATVTLSVPGRKVASRPGPVPEAAQPFLFAPRTPNVGG----PG-----GPQVEWTAR

PF02736 // ENSGT00760000118919_8_Domain_0 (59, 98)

RM
VW--VPSELHGFEAAALRDEGEEEAEVELAESGRRLR

ENSGT00760000118919_8_Linker_0_1 (98, 115)

LPRDQIQRMNPPKFSKA

PF00063 // ENSGT00760000118919_8_Domain_1 (115, 982)

EDMAEL
TCLNEASVLHNLRERYYSGLIYTYSGLFCVVINPYKQLPIYTEAIVEMYRGKKRHEVPPH
IYAVTEGAYRSMLQDR-EDQSILCTGESGAGKTENTKK--V---IQ-------YLAHVAS
SPKGRKEPGVPASVST------------------------------------MSYGELER
QLLQANPILEAFGNAKTVKNDNSS-RFGK------FIRINFDIAGYIVGANI--ETYLLE
KSRAIRQAKDECSFHI----FYQLLGGAG--EQLKADLLLEPYSHYRFLTNGPSSSPGQE
RE-LFQETLESLRVLGLLPEEITAMLRTVSAVLQFGNIVLKKERNTDQATMPDNTAAQKL
CRLLGLGVTDFSRALLTPRIK-VGRDYV----QKAQTKEQADFALEALAKATYERLFRWL
VLRLNRALDRSPRQGASFLGILDIAGFEIFQLNSFEQLCINY-TNEKLQQLFNHTMFVL-
-EQEEYQREGIPWTFLDFGLDLQPCIDLIER-------------PANPPGLLALLDEECW
FPKATDK-SFVEKVAQEQGSHPKFQRPRNLRDQADFSVLHYAGKVDYKANEWLMKNMDPL
NDNVAALLHQSTDRLTAEIWKD--------------------------------------
------------VEGIVGLEQVSSLGDG-P-P-GGRPRRGMFRTVGQLYKESLSRLMATL
SNTNPSFVRCIVPNHEKRAGKLEPR---------LVL-----DQLRCNGVLEGIRICRQG
FPNRI-------------------LF--QEFRQRYEILTPNA---IPKGFMDGKQACEKM
IQALELDPNL-YRVGQSKIFFRAGVLAQLEEERDLKVTDIIVSFQAAARG--YLARRAFQ
R-RQQQQSALRVMQRNCAAYLKLRNWQWWR-----------------LFIKV--KPLLQV

PF01576 // ENSGT00760000118919_8_Domain_13 (1081, 2504)

TR--QDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCSE
A---EETRARLAARKQ-ELELVVTEL----EAR-------VGEEEECSRQLQSEKKRLQQ
HIQELETHL------------EAEEGARQKLQLEKVTTEAKMKKFEE-DLLLLE---DQN
SKLSKERRLLEERLAEFSSQAAE--------EEEKVKSLNKLRVKYEATIADMEDRLKKE
EKGRQELEKLKRRLDGESSE-LQEQMMEQKQRAEE-LLIQLGR--KEEELQSALVRAEEE
GGARAQLLKSLREAQAGLAEAQEDLEAERVARAKAEKQRRDLGEELEALRGELEDTLDST
NAQQELR---SKREQEVTELKKTLEEEARTHEVAMQELRQRHSQALVELTEQLEQARR--
-GKSVWEKTRLSLEAEVSELKTELSSLQTSRQEGEQKRRRLESQLQ--------------
------------------EVQG------RSSDSERARAE---------------------
-AAEKLQRAQVELESVSTALSEAESKAIRLSKELSSAESQLHDTQELLQEETRAKLALGS
RVRALEAE-------------------------------AAGLREQMEEEVVARERAGRE
----------LQTTQAQLSEWRRRQEEEAAVLEAGEEARRRAAREAETLAQ-----RLAE
KTEAVE---RLERARRR-----------LQQELDDA------------------TVDLG-
---QQKQLLSTLEKKQRKFDQLL----------AEEKAAVLRAVEDRERVEAEGREREAR
ALSLTRALEEEQEAREE-----------------------LERQNRALRAELEALLSSKD
DVGKNVHELERARRVA--------EQAAS-DLRTQVTELED----ELTAA-EDAKLRLEV
TV---QALKAQHERDLQGRDDAGEERRRQLAKQLRDAEVERDEE-RKQRALAMAARK-KL
ELELEELKAQTSA-----------A-GQGKEEAVKQL---KK------------------
-MQA-QMKELWREVEETRSS-REEMF-TLSRESEKRLKGLEAEVLRLQEELAASDRARRQ
AQQDRDEMAEEVASGNLSKAATLEEKRQLEGRLGQLEEELEEEQNNSELLKDHYRKLVLQ
VETLTT---------ELSAERSFSAKAESGRQQLERQIQELRARLGEEDAGARAR--QKM
LIAALESKLAQAEEQLEQES----------------------------------------
----------RERILSGKLVRRAEKRLKEVVLQVDEERRVADQLRDQLEKSNLRLKQLKR
QLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLR---------------
------------------------------------RGPLTFTTRTVRQVFRLEEGVASD
EEE-AEGAEPGSAPT-QEPEAPPPAAPQ--

MAAVTMSVPGRKAPPRPGPVPEAAQPFLFTPRGPSAGG----GPG-SGTSPQVEWTAR

PF02736 // ENSGT00760000118919_8_Domain_0 (59, 98)

RL
VW--VPSELHGFEAAALRDEGEEEAEVELAESGRRLR

ENSGT00760000118919_8_Linker_0_1 (98, 115)

LPRDQIQRMNPPKFSKA

PF00063 // ENSGT00760000118919_8_Domain_1 (115, 973)

EDMAEL
TCLNEASVLHNLRERYYSGLIYTYSGLFCVVINPYKQLPIYTEAIVEMYRGKKRHEVPPH
VYAVTEGAYRSMLQGD---------GESGAGKTENTKK--V---IQ-------YLAHVAS
SPKAGL-----AWPPAPF-------------------------SLTSCIISCARQGELER
QLLQANPILEAFGNAKTVKNDNSS-RFGK------FIRINFDVAGYIVGANI--ETYLLE
KSRAIRQAKDECSFHI----FYQLLGGAG--EQLKADLLLEPCSHYRFLTNGPSSSPGQE
RE-LFQETLESLRVLGFTHEEIISMLRMVSAVLQFGNIALKRERNTDQATMPDNTAAQKL
CRLLGLGVTDFSRALLTPRIK-VGRDYV----QKAQTKEQADFALEALAKATYERLFRWL
VLRLNRALDRSPRQGASFLGILDIAGFEIFQLNSFEQLCINY-TNEKLQQLFNHTMFVL-
-EQEEYQREGIPWTFLDFGLDLQPCIDLIER-------------PANPPGLLALLDEECW
FPKATDK-SFVEKVAQEQGGHPKFQRPRHLRDQADFSVLHYAGKVDYKANEWLMKNMDPL
NDNVAALLHQSTDRLTAEIWKDEHGGFQQFSFLGSFP---------PSPPGSAERCSSAS
SPPG--------VEGIVGLEQVSSLGDG-P-P-GGRPRRGMFRTVGQLYKESLSRLMATL
SNTNPSFVRCIVPNHEKRAGKLEPR---------LVL-----DQLRCNGVLEGIRICRQG
FPNRI-------------------LF--QEFRQRYEILTPNA---IPKGFMDGKQACEKM
IQALELDPNL-YHLL------PGWVLAQLEEERDLKVTDIIVSFQAAAPGDTWLAGGAFQ
K-RQQQQSALRVMQRNCAAYLKLRHWQWWR-----------------LFTKV--KPLLQV

PF01576 // ENSGT00760000118919_8_Domain_13 (1081, 2504)

TR--QDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAE
A---EETRGRLAARKQ-ELELVVSEL----EAR-------VGEEEECSRQMQTEKKRLQQ
HIQELEAHL------------EAEEGARQKLQLDKVTTEAKMKKFEE-DLLLLE---DQN
SKLSKERKLLEDRLAEFSSQAAE--------EEEKVKSLNKLRLKYEATIADMEDRLRKE
EKGRQELEKLKRRLDGESSE-LQEQMVEQQQRAEE-LRAQLGR--KEEELQAALARAEDE
GGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDST
NAQQELR---SKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRG-
--KGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLESQLQ--------------
------------------EVQG------RAGDGERARAE---------------------
-AAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGS
RVRAMEAE-------------------------------AAGLREQLEEEAAARERAGRE
----------LQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQ-----RLAE
KTETVD---RLERGRRR-----------LQQELDDA------------------TMDLE-
---QQRQLVSTLEKKQRKFDQLL----------AEEKAAVLRAVEERERAEAEGREREAR
ALSLTRALEEEQEAREE-----------------------LERQNRALRAELEALLSSKD
DVGKSVHELERACRVA--------EQAAN-DLRAQVTELED----ELTAA-EDAKLRLEV
TV---QALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEE-RKQRTLAVAARK-KL
EGELEELKAQMAS-----------A-GQGKEEAVKQL---RK------------------
-MQA-QMKELWREVEETRTS-REEIF-SQNRESEKRLKGLEAEVLRLQEELAASDRARRQ
AQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQ
VESLTT---------ELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARAR--HKM
TIAALESKLAQAEEQLEQET----------------------------------------
----------RERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKR
QLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLR---------------
------------------------------------RGPLTFTTRTVRQVFRLEEGVASD
EE--AEEAQPGSGPS-PEPEGSPPAHPQ--

---------------------------------------------------QVEWTARRL
VW--VPSELHGFEAAALRHEGEVEAEVELAESGRRLRLPRDQIQRMNPPKFSKA

PF00063 // ENSGT00760000118919_8_Domain_1 (115, 982)

EDMAEL
TCLNEASVLHNLRERYYSGLIYTYSGLFCVVINPYKQLPIYTEAIVEMYRGKKRHEVPPH
VYAVTEGAYRSMLQDR-EDQSILCTGESGAGKTENTKK--V---IQ-------YLAHVAS
SPKGRKEPGVPQQQKKPV--------------------------------SRAPQGELER
QLLQANPILEAFGNAKTVKNDNSS-RFVSAGGEQRLAAGSWELWGWILGLTPRGHPDLLE
KSRAIRQAKDECSFHI----FYQLLGGAG--EQLKVALILDTKPEYMYLAHCALRLPGTS
DRHSGQEGATFVHYSNFMLEELLSMLRIVSAVLQFGNIVLKRERNNDQASMPDNTAAQKL
CRLLGLGVTDFSRALLTPRIK-VGRDYV----QKAQTKEQADFALEALAKATYERLFRWL
VLRLNRALDRSPRQGASFLGILDIAGFEIFQLNSFEQLCINY-TNEKLQQLFNHTMFVL-
-EQEEYQREGIPWTFLDFGLDLQPCIDLIER-------------PANPPGLLALLDEECW
FPKATDK-SFVEKVAQEQGGHPKFQRPRNLRDQADFSVLHYAGKVDYKANEWLMKNMDPL
NDNVAALLHLSTDKLTAEIWKDGELSCCNK--AHSF------------WNGLSGR-----
------HGAQPPMEGIVGLEQVSSLGDG-P-P-GGRPRRGMFRTVGQLYKESLSRLMATL
SNTNPSFVRCIVPNHEKRAGKLEPR---------LVL-----DQLRCNGVLEGIRICRQG
FPNRI-------------------LF--QEFRQRYEILTPNA---IPKGFMDGKQACEKM
IQALELDSNL-YRVGQSKIFFRAGVLAQLEEERDLKVTDIIVSFQAAARG--YLARKAFQ
K-RQQQQSALRVMQRNCAAYLKLRHWQWWR-----------------LFIKV--KPLLQV
TR--QDEVLQARAQELQKVQELQQQSAREVCELQGRLTQLEEERARLAEQLRAEAELCAE
A---EETRGRLAARKQ-ELELVVTEL----EAR-------VGEEEECSRQLQSDKKRLQQ
HIQELESHL------------EAEEGARQKLQLEKVTTEAKLKKFEE-DLLLLE---DQN
AKLSKERKLLEERLAEFSSQAAE--------EEEKVKSLNKLRLKYEATIADMEDRLRKE
EKGRQELEKLKRRLDGESSE-LQEQMAEQ

PF01576 // ENSGT00760000118919_8_Domain_13 (1350, 2557)

QQRGEE-LRAQLGR--KEEELQAALARVEEE
GGARALLLKSLREAQAGLAEAQEDLEAERAARAKAEKQRRDLGEELEALRSELEDTLDST
NAQQELR---SKREQEVTELKKALEEETRIHEVAVQELRQRHGQALGELTEQLEQARRS-
--KGTWEKTRLALETEVSELRSELSSLQASRHEGEQRRRRLESQLQ--------------
------------------EVQG------RAGDGERARAE---------------------
-ATEKLQRVQAELENMSAALSEAESKVIRLSKELGSSETQLHDTQEMLQEETRAKLACGS
RARALEAE-------------------------------VVGLREQLEEEAVARERMARE
----------LQTAQAQLSEWRRRQEEEAGALEAGEEARRRATREAEALTQ-----RLAE
KTE---------AGRRQ-----------LGQELDDA------------------LMDLE-
---QQRQLVSTLEKKQRKFDQLL----------AEEKAAVLRAVEERERVEAEGREREAR
TLSLTRALEEEQEAREE-----------------------LERQNRALRAEMEALLSSKD
DAGKTAHEQERSRRAA--------EQIAS-DLRAQVTELED----ELTAA-EDAKLRLEV
TL---QALKAQQERDLQSRDEAGEERRRQLAKQLRDAEVERDEE-RKQRALAVAARK-KL
EAELEDLRAQNAA-----------A-QQGKEEAGKQL---RK------------------
-MQA-QMKELWREVEESRTS-REEIF-GQNRESEKRLKALEAEVLRLQEELAASDRARRQ
IQQERDEMADELANGSLSKAAILEEKRQLEGRLGQMEEELEEEQSNSELLNDRYRKLLLQ
VESLTT---------ELSAERSFSAKAESGRQQLERQMQELRGRLGEEDAGARAR--QKM
IIAALESKLAQAEEQLEQES----------------------------------------
----------RERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKR
QLEEAEEEASRAQSVRRRLQHELEDVTEASESMNRELNTLRNRLR---------------
------------------------------------RGPLTFTTRTVRQVFRLEEGVVSE
EE--AEEAEPGAGPAPPEPDGPPVSQPQ--

MAAVTMSVSGRKVSSRPGPVPEAAQSFLYAPRTPNVGG----PG-----GPQVEWTAR

PF02736 // ENSGT00760000118919_8_Domain_0 (59, 98)

RM
VW--VPSELHGFEAAALRDEGEEEAEVELAESGRRLR

ENSGT00760000118919_8_Linker_0_1 (98, 115)

LPRDQIQRMNPPKFSKA

PF00063 // ENSGT00760000118919_8_Domain_1 (115, 982)

EDMAEL
TCLNEASVLHNLRERYYSGLIYTYSGLFCVVINPYKQLPIYTEAIVEMYRGKKRHEVPPH
VYAVTEGAYRSMLQDR-EDQSILCTGESGAGKTENTKK--V---IQ-------YLAHVAS
SPKGRKEPGVPVSHTALGHSRHV------------------TNSILYFGLHSTFTGELER
QLLQANPILEAFGNAKTVKNDNSS-RFGK------FIRINFDIAGYIVGANI--ETYLLE
KSRAIRQAKDECSFHI----FYQLLGGAG--EQLKADLLLEPCSHYRFLTNGPSSSPGQE
RE-LFQETLESLRVLGLLPEEITAMLRTVSAVLQFGNIVLKKERNTDQATMPDNTAAQKL
CRLLGLGVTDFSRALLTPRIK-VGRDYV----QKAQTKEQADFALEALAKATYERLFRWL
VLRLNRALDRSPRQGASFLGILDIAGFEIFQLNSFEQLCINY-TNEKLQQLFNHTMFVL-
-EQEEYQREGIPWTFLDFGLDLQPCIDLIER-------------PANPPGLLALLDEECW
FPKATDK-SFVEKVAQEQGSHPKFQRPRNLRDQADFSVLHYAGKVDYKASEWLMKNMDPL
NDNVAALLHQSTDRLTAEIWK---------------------------------------
-----------DVEGIVGLEQVSSLGDG-P-P-GGRPRRGMFRTVGQLYKESLSRLMATL
SNTNPSFVRCIVPNHEKRAGKLEPR---------LVL-----DQLRCNGVLEGIRICRQG
FPNRI-------------------LF--QEFRQRYEILTPNA---IPKGFMDGKQACEKM
IQALELDPNL-YRVGQSKIFFRAGVLAQLEEERDLKVTDIIVSFQAAARG--YLARRAFQ
R-RQQQQSALRVMQRNCAAYLKLRNWQWWR-----------------LFIKV--KPLLQV

PF01576 // ENSGT00760000118919_8_Domain_13 (1081, 2504)

TR--QDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERTRLAEQLRAEAELCSE
A---EETRARLAARKQ-ELELVVTEL----EAR-------VGEEEECSRQLQSEKKRLQQ
HIQELESHL------------EAEEGARQKLQLEKVTTEAKMKKFEE-DLLLLE---DQN
SKLSKERRLLEERLAEFSSQAAE--------EEEKVKSLNKLRLKYEATISDMEDRLKKE
EKGRQELEKLKRRLDGESSE-LQEQMVEQKQRAEE-LLAQLGR--KEDELQAALLRAEEE
GGARAQLLKSLREAQAGLAEAQEDLEAERVARAKAEKQRRDLGEELEALRGELEDTLDST
NAQQELR---SKREQEVTELKKALEEESRAHEVSMQELRQRHSQALVEMAEQLEQARRG-
--KGVWEKTRLSLEAEVSELKAELSSLQTSRQEGEQKRRRLESQLQ--------------
------------------EVQG------RSSDSERARSE---------------------
-AAEKLQRAQAELESVSTALSEAESKAIRLGKELSSAESQLHDTQELLQEETRAKLALGS
RVRALEAE-------------------------------AAGLREQMEEEVVARERAGRE
----------LQSTQAQLSEWRRRQEEEAAVLEAGEEARRRAAREAETLTQ-----RLAE
KTEAVE---RLERARRR-----------LQQELDDA------------------TVDLG-
---QQKQLLSTLEKKQRKFDQLL----------AEEKAAVLRAVEDRERIEAEGREREAR
ALSLTRALEEEQEAREE-----------------------LERQNRALRAELEALLSSKD
DVGKNVHELERARKAA--------EQAAS-DLRTQVTELED----ELTAA-EDAKLRLEV
TV---QALKAQHERDLQGRDDAGEERRRQLAKQLRDAEVERDEE-RKQRALAMASRK-KL
ELELEELKAQTSA-----------A-GQGKEEAVKQL---KK------------------
-MQV-QMKELWREVEETRSS-RDEMF-TLSRENEKKLKGLEAEVLRLQEELAASDRARRQ
AQQDRDEMAEEVASGNLSKAATLEEKRQLEVRLSQLEEELEEEQNNSELLKDHYRKLVLQ
VESLTT---------ELSAERSFSAKAESGRQQLERQIQELRARLGEEDAGARAR--QKM
LIAALESKLAQAEEQLEQES----------------------------------------
----------RERILSGKLVRRAEKRLKEVVLQVDEERRVADQVRDQLEKSNLRLKQLKR
QLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLR---------------
------------------------------------RGPLTFTTRTVRQVFRLEEGVASD
EEE-AEGAEPGSAP-GQEPEAPPPATPQ--

MAAVTMSVPGRKVPPRPGPVPEAAQPFLFTPRGPSMGG----GPGGSGTSPQVEWTAR

PF02736 // ENSGT00760000118919_8_Domain_0 (59, 98)

RL
VW--VPSELHGFEAAALRDEGEEEAEVELAESGRRLR

ENSGT00760000118919_8_Linker_0_1 (98, 115)

LPRDQIQRMNPPKFSKA

PF00063 // ENSGT00760000118919_8_Domain_1 (115, 982)

EDMAEL
TCLNEASVLHNLRERYYSGLIYTYSGLFCVVINPYKQLPIYTEAVWDYP---------WL
SLTTVSGDVSLLVPTDREDQSILCTGESGAGKTENTKK--V---IQ-------YLAHVAS
SPKGRKEPGVPASASTM------------------------------------SYGELER
QLLQANPILEAFGNAKTVKNDNSS-RFGK------FIRINFDVAGYIVGANI--ETYLLE
KSRAIRQAKDECSFHI----FYQLLGGAG--EQLKADLLLEPSSHCRFLTHGPPPAPSQE
RE-LFQETLESLRVLGFTHEEITSMLRTVSAVLQFGNVVLKSERNTDQATMPDNTAAQKL
CRLLGLGVTDFSRALLTPRIK-VGRDYV----QKAQTKEQADFALEALAKATYERLFRWL
VLRLNRALDRSPRQGASFLGILDIAGFEIFQLNSFEQLCINY-TNEKLQQLFNHTMFVL-
-EQEEYQREGIPWTFLDFGLDLQPCIDLIER-------------PANPPGLLALLDEECW
FPKATDK-SFVEKVAQEQGGHPKFQRPRHLRDQADFSVLHYAGKVDYKANEWLMKNMDPL
NDNVAALLHQSTDRLTAEIWKDEHGGFQHFSFLDSFP---------PAAPGSAGRFGSAV
S--------ASGVEGIVGLEQVSSLGDG-P-P-GGRPRRGMFRTVGQLYKESLSRLMATL
SNTNPSFVRCIVPNHEKRAGKLEPR---------LVL-----DQLRCNGVLEGIRICRQG
FPNRI-------------------LF--QEFRQRYEILTPNA---IPKGFMDGKQACEKM
IQALDLDPNL-YRVGQSKIFFRAGVLAQLEEERDLKVTDIIVSFQAAARG--YLARRAFQ
K-RQQQQSALRVMQRNCAAYLKLRHWQWWR-----------------LFTKV--KPLLQV

PF01576 // ENSGT00760000118919_8_Domain_14 (1081, 1499)

TR--QDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAE
A---EETRERLAARKQ-ELELVVSEL----EAR-------MGEEEECSRQLQTEKRRLQQ
HIQELETHL------------EAEEGARQKLQLEKVTTEAKLKKFEE-DLLLLE---DQN
AKLSKERRLLEERLAEFSSQAAE--------EEEKIKSLNKLRLKYEAMIADMEEPLGAG
RS---PGLEKLRALDGESSS-CSRWRSTTEARLRR-AAEAAGR--RSLQAACQVAAAEDE
GGARAQMLKSLREAQAALAEAQEDLEAERAARAKAEKQRRDLGEELEALRGELEDTLDST
NAQQELR---SKREQEVTELKKALEEETRVHEVAVQELRQRHGQALGELAEQLEQARRVG
RGRGAGEGTRQASTARF----------LQPRPRGE----------R--------------
------------------RVGG------EGGEG--SLAG---------------------
-GLILLPSPQAELENVSGALSEAESKAIRLSKELSSTEAQLHDAQEVLQEETRAKLALGS
RVRALEAE-------------------------------AAGLREQLEEEAAARERAGRE
----------LQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQ-----RLAE
KTETAD---RLERGRRR-----------LQQELDDA------------------TMDLE-
---QQRQLVSTLEKKQRKFDQLL----------AEEKAAALRAVEERERAEAEGREREAR
ALALARALEEEQEAREE-----------------------LERQNRALRAELEALLSSKD
DVGKSVHELERARRVA--------EQAAS-DLRTQVTELED----ELTAA-EDAKLRLEV
TV---QALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEE-RKQRALAVAARK-KL
EAELEELRAQTAA-----------A-GQGKEEAVKQL---RK------------------
-MQA-QMKELWREVEETRSS-RDDIF-GLNRESEKRLKALEAEVLRLQEELAASDRARRQ
AQQDRDEMADEVANGNLSKAAILDEKRQLEGRLGQMEEELEEEQSNAELLNDRYRKLLLQ
VESLTT---------ELSAERSFSAKAESGRQQLERQIQELRGRLSEEDAGARAR--QKM
AIAALESKLAQAEEQLEQES----------------------------------------
----------RERILSGKLLRRAEKRIKEVVLQVEEERRGADQLRDQLEKGNIRVKQLKR
QLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLR---------------
------------------------------------RGPLTFTTRTVRQVFRLEEGVASD
EE--TEEAEPGAGPPAPEADGSPQAQPQ--

MAAMTLSVSGRKVAARPGPVPESAQPFLFAPRTPNVGG----PG-----GPQVEWTAR

PF02736 // ENSGT00760000118919_8_Domain_0 (59, 98)

RM
VW--VPSELHGFEAAALRDEGEEEAEVELAESGRRLR

ENSGT00760000118919_8_Linker_0_1 (98, 115)

LPRDQIQRMNPPKFSKA

PF00063 // ENSGT00760000118919_8_Domain_1 (115, 982)

EDMAEL
TCLNEASVLHNLRERYYSGLIYTYSGLFCVVINPYKQLPIYTEAIVEMYRGKKRHEVPPH
VYAVTEGAYRSMLQDR-EDQSILCTGESGAGKTENTKK--V---IQ-------YLAHVAS
SPKGRKEPGVPASVST------------------------------------MSYGELER
QLLQANPILEAFGNAKTVKNDNSS-RFGK------FIRINFDVAGYIVGANI--ETYLLE
KSRAIRQAKDECSFHI----FYQLLGGAS--EQLKADLLLEPCSHYRFLTNGPSSSPGQE
RE-LFQETLESLRVLGFLPDEITAMLRTISAVLQFGNIVLKRERNTDQATMPDNTAAQKL
CRLLGLGVTDFSRALLTPRIK-VGRDYV----QKAQTKEQADFALEALAKATYERLFRWL
VLRLNRALDRSPRQGASFLGILDIAGFEIFQLNSFEQLCINY-TNEKLQQLFNHTMFVL-
-EQEEYQREGIPWTFLDFGLDLQPCIDLIER-------------PANPPGLLALLDEECW
FPKATDK-SFVEKVAQEQGGHPKFQRPRHLRDQADFSVLHYAGKVDYKANEWLMKNMDPL
NDSVAALLHQSTDRLTAEIWKD--------------------------------------
------------VEGIVGLEQVSSLGDG-P-P-GGRPRRGMFRTVGQLYKESLSRLMATL
SNTNPSFVRCIVPNHEKRAGKLEPR---------LVL-----DQLRCNGVLEGIRICRQG
FPNRI-------------------LF--QEFRQRYEILTPNA---IPKGFMDGKQACEKM
IQALELDPNL-YRVGQSKIFFRAGVLAQLEEERDLKVTDIIVSFQAAARG--YLARRAFQ
R-RQQQQSALRVMQRNCAAYLKLRNWQWWR-----------------LFTKV--KPLLQV

PF01576 // ENSGT00760000118919_8_Domain_13 (1081, 2504)

TR--QDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEKERLRLTEQLRAEAELCSE
A---EETRARLSARKQ-ELELVVSEL----EAR-------VGEEEECSRQLQSEKKRLQQ
HIQELESHL------------EAEEGARQKLQLEKVTTEAKIKKFEE-DLLLLE---DQN
AKLSKERRLLEERLAEFSSQAAE--------EEEKVKSLNKLRLKYEATIADMEDRLKKE
EKGRQELEKLKRRLDGESSE-LQEQMVEQKQRAEE-LLAQLGR--KEDELQAALVRAEEE
GGARAQLLKSLREAQAGLAEAQEDLEAERAARAKAEKQRRDLGEELEALRGELEDTLDST
NAQQELR---SKREQEVTELKKTLEEEARVHEVAMQELRQRHGQALGELAEQLEQARR--
-GKSVWEKTRITLEAEVSELRAELSSLQTSRQEGEQKRRRLESQLQ--------------
------------------EVQG------RANDVEWSRTE---------------------
-AAEKLQRTQAELESVSTALSEAESKAIRLGKELSSAESQLHDTQELLQEETRAKLALGS
RVRALEAE-------------------------------AAGLREQMEEEVVARERAGRE
----------LQSAQAQLSEWRRRQEEEAGVLEAGEEARRRAAREAEALAQ-----RLAE
KTEAVE---RLERARRR-----------LQQELDDA------------------TVDLG-
---QQKQLVSTLEKKQRKFDQLL----------AEEKAAVLRAVEDRERVEAEGREREAR
ALSLTRALEEEQEAREE-----------------------LERQNRALRAELEALLSSKD
DVGKNVHELERARRVA--------EQAAN-DLRTQVTELED----ELTAT-EDAKLRLEV
TV---QALKAQHERDLQGRDDAGEERRRQLAKQLRDAEVERDEE-RKQRALAVAARK-KL
EAELEELKAQTSA-----------A-GQGKEEAVKQL---KK------------------
-MQA-QMKELWREVEETRSS-REEIF-TLNKESEKRLKGLEAEVLRLQEELAASDRARRQ
AQQDRDEMAEEVANSNLSKTAILDEKRQLEGRLGQLEEELEEEQNNSELLKDHYRKLLLQ
VETLTT---------ELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARAR--QKM
LIAALESKLAQAEEQLEQES----------------------------------------
----------RERILSGKLVRRAEKRLKEVVLQVDEERRVADQLRDQLEKSNLRLKQLKR
QLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLR---------------
------------------------------------RGPLTFTTRTVRQVFRLEEGVASD
EEE-AEGAEPGHAPP-QEPEAPPPVTPQ--

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VWCGSPSETHGFEAAALRDEGPEEAEVELAESGRRLRLPRDQVQRMNPPKFSKA

PF00063 // ENSGT00760000118919_8_Domain_1 (115, 523)

EDMADL
TCLNEASVLHNLRERYYSDLIYTYSGLFCVVINPYKQLPIYTEAIVEMYRGKKRHELPPH
VYAVTEGAYRSMLQDR-EDQSILCTGESGAGKTENTKKV-----IQ-------YLAHVAS
SPKGRREQGGPTAGVV-------------------------------------SYGELEK
QLLQANPILEAFGNAKTVKNDNSS-RFGK------FIRINFDVAGYIVGANI--ETYLLE
KSRAIRQAKDECSFHI----FYQLLEGAG--EKLKDDLLLEPCSQYRFLTNGPGPGSAQQ
ERELFQETLESLRVLGFTHEEITSMLRIVSAVLQFGNITLRKERNTDQATMPDNTAAQKL
CCLLGLGVTDFSRALLSPRIK-VGRDYV----QKAQTKEQARLGFGSQVAILVERAWAWD
SEVLG------SRPGSTTCLLCDLRGLVIWHLPQHLAQCLVQ-----TRLLVNATMFLIS
LPPNR--KIGTESRGVQTG------PDR----------IQLRPDPASEPGLQGFQKITII
I-------MVV---------------------------------LLLNSPKCLERRSAPS
KHSVCAIDIGKTEKGSSERR--------------------------------------DR
DPTRGPVVCGE------------GLGEA---SRGGGLAAPFPSSLGEPDPSALSFIHSFL
PSFLPSFLPSFLPSFLP-----------SF-LPSIVFIEHLLRAEHCAKHL--------G
EYNII-------------------II--MVFVKRLL--YARTHSLIPHFTDEVTEAQRSE
IKALDLDPNL-YRVGQSKIFFRAGVLAQLEEERDLKVTDIIVSFQAAARG--YLARRSGT
WKEHTHTH-----THTHTYSLSLAHTHSYSFTICASAELDTKSALRTVSAQL--IPLINR
SSPIPHRVLGSLSLSLNP-LACSFPLCP-------------PPVPGTAEQVPSPKP----
------APPAAAAAGQ-SPSVFTSS-----PTR-------VRRTQDPI--TSLTSKAQPQ
QGKELESHL------------EAEEGARQKLQLEKVTTEAKLKELEE-QLLLLE---DQN
AKLGK-------------------------------------------------------
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MAAVTFSVAGRKAPPPAGPVPA-EQPYMFAPRASSV--------GGPGAAPQVEWTARRL
VW--VPSELHGFEA-ALRDEGEEEAEVELAESGRRLRLPRDQIQRMNPPKFSKA

PF00063 // ENSGT00760000118919_8_Domain_4 (115, 243)

EDMAEL
TCLNEASVLHNLRERYYSGLIYTYSGLFCVVINPYKQLPIYTEAIVEMYRGKKRHEVPPH
VYAVTEGAYRSMLQDR-EDQSILCTGESGAGKTENTKK--V---IQ-------YLAHVAS
SPKGRKEPGVPVSDLPRDVLWTLPPALAG------------------------SRGRAD-
-AETRGPVLGLVGPG----------------------NPAW----HIVGASIPEHPLCAG
------PGLGTCGAQVCFLKTECVAGGVG--SQRKGSIAPAPCISPCPAPTEPAGSPVCL
ST-FHVLCLRQLRVLWPMLPFAAVLLCVCSCTLLFLSALLYGAHRHQEFTQPGDPHSHFL
CRRRSPSVSAQSKSLLILAASRGAMRGVVGTGPSD-------ARLPA-YSATRARSLDGL
ARNINKCIEVSYTHGLTFIEHLPCAWGPLTFLNQVPSHNIVFFSADHL---SSATKFSLY
EQQAASQGQVPGWEWLSRLSCPQPCAGLGVRRGLWPRGAP------------DCRGEHVW
RIMQTGHVTGVERLRKEAVADEVVERAKGGRPGGGGCSSG

PF00063 // ENSGT00760000118919_8_Domain_6 (701, 860)

YGHKVDYKANEWLMKNMDPL
NDSVATLLHQSTDRLTAEIWK---------------------------------------
-----------DVEGIVGLEQVSSLGDG-P-P-GGRPRRGMFRTVGQLYKESLSRLMATL
SNTNPSFVRCIIPNHEKRVNHKIRC-------PRLTLSSE-----SSGGSWVGGCVCASP
FPHLQ-------------------I---PYFTKSETLISPTL---FPWGSFDWWQGGHQW
LQAFILPPQL-YSLGEVVKFVCSALAAQGSPVRIL-GTDLHTTRQAMAVAAK-KKEEDWQ
QMLAQGQSSSP--KKKKKKKKKNRNIQTVA-----------------LFIYL--LPTLLV
TD--THSLREAVSRHRDAHEGCTQEWCVQAAAVGGRLHSNKRVSAMSTPGIRTGEPRASK
A---EHAHLTAAPPGR-PLNLFLNRL----QKN-------SWLDERCPRPPAPRSSPRPP
PSQELETHL------------EAEEAARQKLELERVTTEAKLKKFEE-DLLLLE---DQN
AKLSKERKLLEDRLSEFSSQAAE--------EEEKVKSLNKLRLKYEATIADMEDRLRKE
EKGRQEMEKLKRRLDVESSE-LQEQMGE

PF01576 // ENSGT00760000118919_8_Domain_13 (1349, 2448)

QQQRAEE-LRAQLGR--KEEELQAALARAEEE
GGARAQLLKSLREAQAGLAEAQEDLEAERAARAKAEKQRRDLGEELEALRGELEDTLDST
NAQQELR---SKREQEVTELKKALEEETRVHEVAVQELRQRHGQALGELAEQLEQARRG-
--KSAWEKTRLALEAEVSELRGELNSLQTSRQEGEQKRRRLESQLQ--------------
------------------EVQG------RAGDGERARAE---------------------
-AAEKLQRAQAELENVSGALSEAESRAIRLSKELSSTEAQLHDAQELLQEETRAKLALGS
RARALEAE-------------------------------AAGLREQLEEEASARERAGRE
----------LQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAETLTQ-----RLAE
KTEVVD---RLERGRRR-----------LQQELDDA------------------TMDLE-
---QQRQLVSTLEKKQRKFDQLL----------AEEKAAVLRAVEERERVEAESREREAR
ALSLARALEEEQEAREE-----------------------LERQNRALRAELEALLSSKD
DVGKSVHELERARRVA--------EQAAN-DLRTQVTELED----ELTAA-EDAKLRLEV
TM---QALKAQHERDLQGRDETGEERRRQLAKQLRDAEVERDEE-RKQRALAVAARK-KL
EAELEELKAQMSA-----------A-GQGKEEAVKQA---RK------------------
-MQVTKVRDLWRGQEEVNTSPRDALF-TCRQETCRPVTTADHPLSLSPQELAASDRARRQ
AQQERDEMADEVANGSLGKAAILEEKRQLEVRLGKMEEELEEEQSNAELLNDRYRKLLLQ
VESLTT---------ELSAERSFSAKAESGRQQLERQIQELRARLGEEDAGARAR--QKM
VIAALESKLAQAEEQLEQES----------------------------------------
----------RERILSGKLVRRAEKRLKEVVLQVEEERRAADQLRDQV------------
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