ENSGT00760000118862_0 : Linker Region Query Results

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-----------------MGRPRP-RAAKTWMFLLLLGGAWAACGSLDLL--TKLYAENLP
CVHLNPQW-PSQPS---------HCP------RGWRSNPLPPAAGHSRAQEDKVLGGHEC
QPHSQPWQAALFQ----GQQLLCGG-VLVGGNWV------LTAAHCKKP-----------
KYTV---------------RLGDHSLQNKDGPEQEIPVVQSIPHPCYN-----SSDVEDH
NHDLMLLQLRDQASLGSKVKPISLADHCTQPG-QKCTVSGWGTVTSPRE-----------
-------NFPDTLN-CAEVK--------IFPQ-------KKCEDAYPG-QITDGMVCAGS
S-------KGADTC---QG---------DSGGP---------LV-CDGA-LQGIT--SWG
SD-PCGRSDKPGVYTNICRYLDWIKKIIGSKG----------------------------
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MRASV-LLL-------------------------CV-LALAPRL-SQADTEKIVNGVECV
PHSQ-PWQVGLFE-GTHLRCGGVLIDRRWVLTAAHCRGS---------------------
-----RYLVHLGEH-NLQRPDG--CEQTRTATESFPHPGFNNSLPNKDHRDDIMLVKMAS
PAFVTRAVRPLTLS-RHCVTAGTRCLISGWGTTSSPQLRLPHTLRCANISIIEHSECE--
SAYPGN-ITDTMLCASVEEGGKDSCQGDSGGPLVCNGSLQGIISWGQDPCAVTRKPGVYT
----KVCRY------VDWIQETMENN----------------------------------
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---------------CKS---V---------LFL---TLEGRGWAFARDDTDKMLGGEEC
EPHSQPWQVALFE----RGRFNCGA-SLISAHWV------LSAAHCQTR-------S---
-LRV---------------RLGEHNLRKRDGPEQLRTVARIIPHPRY--------EARSH
RHDVMLLRLTRPARLSRQARPVALPTRCPQPG-EACVVSGWGRPLSS-------------
-----PVSLPDTLH-CANIS--------VIPA-------TSCNEDYPG-RVMASMVCAGV
EG------GGTDSC---EG---------DSGGP---------LV-CGGV-LQGIV--SWG
DV-PCDTTTKPGVYTKVCSYLEWIKETIKRN-----------------------------
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-----MW---PLALV-IASLTAALSGGISQESSKVL------N--TNGTSGFLPGGYTCF
PQSQ-PWQAALLV-QGGLLCGGVLVHPKRVLTAAHCLND---------------------
-----GLKVYLGKH-ALGRVE--AGEQVREVVRSIPHPAYRRSPTHSNHDHDIMLLELQS
LAQLTGYIQTLPLSHNNCLTPGTTCQVSGWGTTTSPQVNYPKTLQCANIQLGSDEECH--
QVCPGK-ITDNMLCASTKEGGKDSREGDSGGPLVCNRTLYGTISWGDFPCGQPD------
-------QY------VLWIRETVRKYETQQQKWLKGPQ----------------------
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------------------------MF----LLLTALQVLAVGLARSQE-DDNKIIGGYTC
IQNSQPWQAALLAG--AGRRFFCGG-ILLSDRWV------ITAAHCARP-----------
TLQV---------------SLGKHNLRRWEATQQVLRVTRQVPHPGY--------RSRTH
ENDLMLLRLEKPARLGRAVRPIPVAQSCASPG-TSCLVSGWGTISSPVV-----------
-------RYPTVLQ-CVNVD--------ISSDQQ-------CRKAYPG-AITSGMVCAGV
PQ------GGKDSC---QG---------DSGGP---------LV-CGGQ-LQGLV--SWG
ME-HCGRPGYPGVYTNLCKYSNWIRETIRGG-----------------------------
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-----MW---PLVAA-IACLTVALSGGISRDYPKIL------NG-TNGTNGFLPGGYTCL
PHSQ-PWQAALLV-RGRLLCGGVLVHPKWILTAAHCRKD---------------------
-----GYTVHLGKH-ALGRVE--IGEQAMEVVRSIPHPEYQVSPTHLNHDHDIMLLELKS
PVQLSSHIRPLPLSPDDCLPTGTCCRVSGWGTTTSPQVNYPKTLQCANIELRSDEECR--
QVYPGK-ITANMLCAGTKEGGKDSCEGDSGGPLVCNGKLYGIISWGDFPCGQPNRPGVYT
----RVSKY------LHWIWETIRNTPKQ--RWTKNTQ----------------------
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-------------------------------MWLLLAFILLVSA--A-QDGDKVLEGEEC
VPHSQPWQVALFE----RGRFNCGA-FLISPHWV------LTAAHCQTR-----------
FMRV---------------RLGEHNLRKFDGPEQLRSVSRIIPHPGY--------EARTH
RHDIMLLRLFRPARLTPQVRPVALPTRCPLLG-EDCVVSGWGLLSDNSPGA-TG------
-SHKSQVRLPDTLH-CANIS--------IISE-------ASCNKDYPG-RVLPTMVCAGV
EG------GGTDSC---EG---------DSGGP---------LV-CGGA-LQGIV--SWG
DV-PCDTTTKPGVYTKVCSYMDWIRKNMRRN-----------------------------
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------MKL--------GF--------------IWA-LLSLLAG-CSWARTRAIGAKECT
RNSQ-PWQAGLFF-LTRLFCGATLISDRWLLTAAHCRK------P---------------
-----HLWVRLGEH-HLWRWEG--PEQLFLATDFFPHPGFNKDLSANDHNHDIMLIRLPR
PARLGPAVQPLNIS-KTCVSPGTKCLISGWGAVSSPKGTFPLTLQCANISILEPMLCH--
WAYPGH-ISDSMICAGRWEGGLGSCQGDSGGPLVCKGALAGVVSGGGEPCSKPRRPTVYT
----SVCHY------DEWIRKTIEANSP--------------------------------
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-------------------------------MWLLLTFSFLLASAVAQDDSDKVQTGEEC
VPHSQPWQVALFE----HGRVNCGA-SLISPQWL-------SAAHCQTR-----------
FLRV---------------RLGEHNLRKRDGPEQLRTVSRIIPHPRY--------EARNH
RQDLMLLRLTRPVRVTAEVLPVPLPARCPQAG-EACVVSGWGLVADKEPGA-TG------
-SPESQVRLPDTLH-CANIS--------IIST-------ASCNKDYAG-HLMDTMVCAGV
EG------GGIDSC---EG---------DSGGP---------LV-CGGV-LQGIV--SWG
DV-PCDPTTKPGVYSKVCSYLEWIKETMKRN-----------------------------
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--------------------------MF--LLLTALQVWAAASAQTQG--DNKIIGGYTC
IQNSQPWQAALLAG--PWNRFLCGG-ALLSERWA------ITAAHCARP-----------
ILRV---------------ALGKHNLNNWEATQQVLRVVRQVPHPQY--------NARTH
DNDLMLLRLERNARLGRAVRTIGLATSCAPNG-TSCRVSGWGTTSSPIA-----------
-------RYPNALQ-CLNIN--------IVSDQE-------CRQAYSN-AITPGMVCAGV
PQ------GGKDSC---Q------------------------------------------
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-----------MSLR---------------------------------------------
-----------VLGSS-TWPSAPKMF----LLLAALQVLAVAMTRSQD-DENKIIGGYTC
ARSSQPWQAALLAG--PGRRFLCGG-ALLSDQWV------ITAAHCGRP-----------
ILRV---------------ALGKHNLKRWEATQQVLRVVRQVTHPNY--------NSRTH
DSDLMLLQLQQPARIGRAIRPIEVAQACASPG-TSCRVSGWGTTSSPIA-----------
-------RYPTSLQ-CVNIN--------ISPDEV-------CGKAYPG-AIKPGMVCAGV
PQ------GGKDSC---QG---------DSGGP---------LV-CKGK-LQGLV--SWG
ME-RCALPGYPGVYTNLCKYRSWIEETMRGK-----------------------------
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------MKLG-------LT--------------L-V-LFSLLAG-HCGADTRAVGARECQ
RNSQ-PWQAGLFY-LTRQLCGATLINDQWLLTAAHCRK------P---------------
-----YLWVRLGEH-HLWQWEG--PEKLLLVTDFFPHPGFNPDLSANDHNDDIMLIRLPR
KVRLSPAVQPLNLS-QSLPSVGTQCLISGWGSVSSSKIQFPMTLQCANISILDNKLCR--
WAYPGH-ISEKMLCAGLWEGGRGSCQGDSGGPLVCKGTLAGIVSGGSEPCSRPQRPAVYT
----SVFHY------LDWIENTVEKYNHTNKLI---------------------------
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------MKLG--------F--------------ICV-LLSLLAG-HCWADTRAIGAQECH
PNSQ-PWQAGLFY-LTRLFCGATLISDRWLLTAAHCRK------P---------------
-----HLWVRLGEH-HLWKWEG--PEQLFRATDFFPHPGFNSDLSANDHNDDIMLIRLPR
RAQLSPAVQPLNLS-QTCVSPGTQCLISGWGAVSSPKALYPVTLQCANISILENKFCR--
WAYPGH-ISDSMLCAGLWEGGRGSCQGDSGGPLVCDGTLAGVVSGGAEPCSRPRRPAVYT
----SVCHY------GDWIRKTMEDN----------------------------------
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-----------------MGRPPPGA-AWTWILL----LLTWA------------------
--AWAGRG-KLHAE---------NFT------LGWHSSPLPPAAGRPRAQESKLLEGQEC
EPHSQPWQTALFQ----GQQLLCGG-VLVGAKWV------LTAAHCKKP-----------
KYTV---------------RLGDHSLQKKDGPEQEISVARSIPHPCYN-----SNDSDNH
NHDLMLLQLRDRASLGSKVKPISLADHCPQVG-QMCTISGWGTVTSPRE-----------
-------NFPDTLN-CAEIR--------IFPQ-------KKCEDAYPG-QVSDGMLCAGN
S-------NGADTC---QG---------DSGGP---------LV-CDGV-LQGIT--SWG
SD-PCGWPERPGVYTNICRYLDWIKKTMGSKG----------------------------
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-----------------------------------------------------M----RR
PRWLKS---DRKSPT---------------A--------------SREPGAHPAP-----
LQARMILHF-------------------------VA-LALVT-G-HVGGETRIIKGYECT
PHSQ-PWQVALFQ-KTRLLCGATLIAPKWLLTAAHCRKP---------------------
-----RYVVLLGEH-NLEKTDG--REQKRMATESFPHPGFNNSLPNKDHRNDIMLVKMSS
PAIITRAVRPLTLS-SHCVTAGTSCLISGWGTTSSPQLRLPHSLRCANVSIIEHQECE--
NSYPGN-ITDTMLCASVRKEGKDSCQGDSGGPLVCDGSLQGIISWGQDPCAVTKKPGVYT
----KVCKY------VDWIHETMRKN----------------------------------
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------------------------ML----LLLTVLQALALAMVQSQG--DHKIIGGYTC
IQNSQPWQVALQTG--PGRRLVCGG-VLLSDRWV------ITAAHCARP-----------
ILHA---------------ALGKHNLRRWEATQQMVRVIRQVPHPQY--------QPRAH
NNDLMLLQLQKRVRLGRAVRTIDVARSCASPG-TPCRVSGWGTTASPVA-----------
-------RYPNALQ-CVNVN--------IMSEEV-------CRRAYSA-TITSGMVCAGV
PE------GGKDSC---QG---------DSGGP---------LV-CGGQ-LQGIV--SWG
ME-RCAMPGYPGVYTNLCNYQNWIQRTMQGN-----------------------------
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-------------MQM-VSFPCTPMR------LLN-TALLLLVLTVAAQDESRIIGGQEC
PKHGQPYQVILSNSRKNGPDVQCGG-VLIDKDWV------LTAAHCDNQ----------G
TIHT---------------RMGDHSLRANEGSEQCIKSAQKFIHPAY--------NPSTH
DSDIMLIRLDNSANINEYVRPIELATQCTKPN-TRCEVSGWGTIKTPQS-----------
-------EFPDLLQ-CATVY--------TISN-------EECNKAYPN-AITENMLCATV
SG------GGVDSC---QG---------DSGGP---------LV-CNNK-LQGIV--SWG
MQ-VCAQAGKPGVYTNICQFTDWIQNTMRGNTGYRAADTC--------------------
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---------------------MERMF------SGRYSFLV-YVFTASAAEAERVPGGKAC
PAHSQPWQAGLFS----GFRLVCGG-TLIHKSWV------LSAAHCRRR----------S
PFPV---------------RLGEHDLKRLDWSEQLKLASKVIVHPNY--------DPQTK
NNDIMLVKLLTPVCLNNKVKILKLPTTCPVPG-TECLISGWGTTTSPEV-----------
-------NFPDVLH-CANIT--------VVDY-------EVCRSIYPN-YINENMVCAGK
ME------GGTDAC---QG---------DSGGP---------LA-CNGQ-LQGIV--SWG
PI-LCGQPNRPGVYVNVCKYVDWIRETIRHN-----------------------------
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-----MW---PLAAA-IASLTVALSGGISQEYPKIL------NG-TNGTSGFLPGGYTCL
PHSQ-PWQAALLV-RGRLLCGGVLVHPKWVLTAAHCLKD---------------------
-----GYRVYLGKH-ALGRAE--AGEQVREVVRSVPHPEYQISSTHLNHDHDIMLLELQS
PVQPTGHVRVLPLSHEDC--------------------SYPKTLQCANIELRSDKECH--
QVYPGK-ITPNMLCAGTKEGGKDSCEGDSGGPLVCNGSLHGIISWGDFPCGQPNRPGVYT
----RVSKY------VSWIQETIQKHNTPEHKWTKGPQ----------------------
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-------------------------------MWLLLTLSFLLASSAAQ-DGDKLLEGDEC
APHSQPWQVALYE----RGRFNCGA-SLISPHWV------LSAAHCQTR-----------
FMRV---------------RLGEHNLRKRDGPEQLRTASRVIPHPRY--------EARSH
RHDIMLLRLVQPARLTPQVRPVVLPTRCPHPG-EACVVSGWGLVSHIEPGT-TR------
-SPQSQVSLPDTLH-CANIS--------IISD-------TSCDKSYPG-RLTNTMVCAGA
EG------RGAESC---EG---------DSGGP---------LV-CGGV-LQGIV--SWG
DV-PCDNTTKPGVYTKVCHYLKWIRETMKRN-----------------------------
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-----MW---PLVAT-IACLTLALSEGISRDYPKIL------NG-TNGTSGFLPGGYTCL
PHSQ-PWQAALLI-RGRLLCGGVLVHPKWVLTAAHCRKD---------------------
-----GYTVHLGKH-ALGRVE--NGEQAMEVVRSIPHPEYQVTPTHLNHDHDIMLLELKS
PVQLSSHVRTLKLSADDCLPTGTCCRVSGWGTTTSPQVNYPKTLQCANIELRSDEECR--
QVYPGK-ITANMLCAGTKEGGKDSCEGDSGGPLICNGKLYGIISWGDFPCGQPNRPGVYT
----RVSKY------LRWIREIIRNTPEQ--RWTKGTQ----------------------
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------------------------MF----LLLIILQALAVAIAQSQG--DHKIIGGYTC
IRNSQPWQVALQAG--PGHRFLCGG-VLLSDQWV------ITAAHCARP-----------
ILHV---------------ALGKHNIRRWEATQQVVRVARQVPHPQY--------QPQAH
DNDLMLLKLQKKVRLGRAVKTIPVASSCASPG-TPCRVSGWGTIASPIA-----------
-------RYPTALQ-CVNVN--------IMSEQA-------CHRAYPG-IITSGMVCAGV
PE------GGKDSC---QG---------DSGGP---------LV-CGGQ-LQGLV--SWG
ME-RCAMPGYPGVYTNLCNYHSWIQRTMQSN-----------------------------
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-----QYLVHLGEH-NLQRPDG--CEQTRTATQSFPHPGFNNSLPNKDHRNDIMLVKMTT
AALITRAVQPLTLS-PHCVSAGTRCLISGWGTTSSPQXXXXXXXXXXXXNIIEHRECE--
DEYPGN-ITETMVCASVREEGKDSCQGDSGGPLVCNGSLQGIISWGQDPCAVSRKPGVYT
----KVCKY------VDWIQEVMKNN----------------------------------
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-----MW---PLAAA-VACLTVALSGGISREYPKIL------NG-TNGTSGFLPGGYTCL
PHSQ-PWQVALLV-KGRLLCGGVLVHPKWVLTAAHCLKV---------------------
-----GYTVHLGKH-VLGRVE--THEQVRAVARSVPHPKYQVSPTHLNHDNDIMLLELET
PVQLTGHIRTLPLSRSDCLPPGTCCRVSGWGTTTSPQVSYPKTLQCANIPLRSDEECH--
HVYPGK-ITTNMLCAGTKEGGKDSCEGDSGGPLVCNNTLYGIISWGDFPCGQPNRPGVYT
----RVSRY------VSWIHETIKDHKTREQKRTKSTQ----------------------
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---MRILRL-------------------------IT-LALVT-G-HVGGETRIIKGYECQ
PHSQ-PWQAALFQ-KTRLLCGAXXXXXXXXXXXXX-------------------------
-XXXXRYIVHLGEH-NLQRRDG--CEQVRTATESFPHPGFNNSLPNKDHRNDIMLVKMVA
PAFVTWAVRPLTVS-SRCVTAGTRCVISGWGSTSSPQLHLPHTLRCANISIIEHRECE--
NAYPGN-VTDTMVCASVQEEGKDSCQGDSGGPLVCNGSLQGIISWGQDPCAVTRKPGVYT
----KVCKY------VDWIQETMKSN----------------------------------
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-----------------MGCPPP-AAVWIWTFLLLL----LE------------------
--A---------------------------------------SAGHLRAQEPKVLEGQEC
QAHSQPWQTALFQ----GVRLLCGG-VLIDDHWV------LTAAHCKKE-----------
KYTV---------------HLGEHSLQNKDGPEQKMSVAQSIPHPCYN-----SS-SEDR
SHDLMLVRLRGRASLGPKVKPIKLADHCPQAG-QKCTISGWGTITSPQG-----------
-------RFWGPAG-M--------------------------------------------
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-------------------------------MWLLLTLSFLLASTAAQ-DGDKLLEGDEC
APHSQPWQVALYE----RGRFNCGA-SLISPHWV------LSAAHCQSR-----------
FMRV---------------RLGEHNLRKRDGPEQLRTASRVIPHPRY--------EARSH
RHDIMLLRLVQPARLTPQVRPAVLPTRCPHQG-EACVVSGWGLVSHNEPGT-TG------
-SPQSQVSLPDTLH-CANIS--------IISD-------TSCDKSYPG-RLTNTMVCAGA
EG------RGAESC---EG---------DSGGP---------LV-CGGI-LQGIV--SWG
DV-PCDNTTKPGVYTKVCHYLEWIRETMKRN-----------------------------
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-----------------MGRPRP-RAAKTWMFLLLLGGAWA-------------------
--------------------------------------------GHSRAQEDKVLGGHEC
QPHSQPWQAALFQ----GQQLLCGG-VLVGGNWV------LTAAHCKKP-----------
KYTV---------------RLGDHSLQNKDGPEQEIPVVQSIPHPCYN-----SSDVEDH
NHDLMLLQLRDQASLGSKVKPISLADHCTQPG-QKCTVSGWGTVTSPRE-----------
-------NFPDTLN-CAEVK--------IFPQ-------KKCEDAYPG-QITDGMVCAGS
S-------KGADTC---QG---------DSGGP---------LV-CDGA-LQGIT--SWG
SD-PCGRSDKPGVYTNICRYLDWIKKIIGSKG----------------------------
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-----MW---PLALV-IASLTVALSGGISQESSKVL------N--TNGTSGFLPGGYTCF
PHSQ-PWQAALLV-RGRLLCGGVLVHPKWVLTAAHCLKE---------------------
-----GLKVYLGKH-ALGRVE--AGEQVREVVYSIPHPEYRRSPTHLNHDHDIMLLELQS
PVQLTGYIQTLSLSHNNRLTPGTTCRVSGWGTTTSPQVNYPKTLQCANIQLRSDEECR--
QVYPGK-ITDNMLCAGTKEGGKDSCEGDSGGPLVCNRTLYGIISWGDFPCGQPDRPGVYT
----RVSRY------VLWIRETIRKYETQQQKWLKGPQ----------------------
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-------------------------------------------------IGFLPGGYTS-
----------LLV-QGGLLCGGVLVHPKRVLTAAHCLND---------------------
-----GLKVYLGKH-ALGRVE--AGEQVREVVRSIPHPAYRRSPTHSNHDHDIMLLELQS
LAQLTGYIQTLPLSHNNCLTPGTTCQVSGWGTTTSPQVNYPKTLQCANIQLGSDEECH--
QVCPGK-ITDNMLCASTKKGGKDSREGDSGGPLVCNRTLYGTISWGDFPCGQPD------
-------QY------VLWIRETVRKYETQQQKWLKGPQ----------------------
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--------------------------MF--FLLTAFQIVALAMAQSQR-DENKIIGGYTC
VQNSQPWQAALLAG--PFRRFLCGG-ALLSGKWA------ITAAHCARP-----------
ILHV---------------ALGKHNLKNWEATQQVLRVVRQVPHPQY--------NSRTH
NNDLMLLQLERPVRLGRAVRPITITSSCASPG-TPCHVSGWGTTSSPIV-----------
-------SYPNSLQ-CVNIN--------ISSDQE-------CRRAYSQ-AITAGMVCAGV
PQ------GGKDSC---QG---------DSGGP---------LV-CKGQ-LQGLV--SWG
ME-RCALPGYPGVYTNLCKYQTWIRKTIRGK-----------------------------
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--------------------------------MALFILALTLVAAAAATDKEKIIAGEKC
KEDGHPYQVAVYR----GGGLLCGG-VLIHPGWV------LTAAHCRKP-----------
QLQV---------------LLGKYNLHKQEEFQQLSPVAQPFPHPDY--------DRGRH
DNDIMLLRLAHPTPVSRHIKPLSLETDCNANS-SSCLISGWGKTD-REG-----------
-------QYPGRGGKCKPSQNRSGLGLPLPLETEMGRGSGSGKETLYN-RISRNVPCQRS
EQ------MGRDPC---LG---------DSGGP---------LV-CGGR-LRGLV--SWG
EV-PCGTGEKPGVYTNVCRYVDWIRETIRGN-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------R-----------
FLRV---------------SLGKHDLRWWEPTEQRRLVVRQIPHPSY--------NPRTQ
DSDLMLLRLDRPVQLTPAVQPLGLSPDCAAPG-TPCRVSGWGTISSPLASP--G------
-PSPSPVRYPDILQ-CVNIQ--------IVSDKA-------CQGAYPG-GITPSMVCAGD
WQ------GGKDSC---QG---------DSGGP---------LV-CRGK-LQGLV--SWG
LE-QCGLSNHPGVYTNLCKFTRWIQNTMRGK-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------ISQESSKIL------N--NNGTSGFLPGGYTCF
PHSQ-PWQAALLV-EGRLLCGGVLVHPKWVLTAAHCLKE---------------------
-----GLKVYLGKH-ALGRVE--AGEQVREVVRSVPHPEYRSSPTHLNHDHDIMLLELQS
PVQLTGYIQTLPLSHNNCITPGTTCRVSGWGTTTSPQVSYPKTLQCANIQLRSDEECH--
QVYPGK-ITANMLCAGTKEGGKDSCEGDSGGPLVCNRTLHGIISWGDFPCGQPDRPGVYT
----RVSRY------ILWIRETIRKHETQQQKWTNGPK----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------MEVVRSIPHPEYQVSPTHLNHDHDIMLLELKS
PVQLSSHIRTLPLSPDDCLPTGTCCRVSGWGTTTSPQVNYPKTLQCANIELRSDEECR--
QVYPGK-ITANMLCAGTK------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------MPPPL-PR---------------------------------------------
-----------QETSR-IQPPALRMFL----MLMALQILAVAVAQNQG-NENKIIGGYTC
IRSSQPWQAALLQG--PQRRFLCGG-SLLSDQWV------ITAAHCARL-----------
ILRV---------------ALGKHNLKIPEATQQVLRVVRQVPHPQY--------NSRTN
DNDLMLLQLERPARLGPGVQPISVASSCAGAG-TSCLVSGWGTTSSPVA-----------
-------RYPNSLQ-CVDIN--------IFSDQE-------CRRAYSG-AITPGMVCAGV
PQ------GGKDSC---QG---------DSGGP---------LV-CGGQ-LQGLV--SWG
ME-RCAQPGYPGVYTNLCKYHTWIQRTIQRRS----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------M----RK
LRCLKDWQASSRVHP---------------A--------------SKAPGACPAP-----
LQAAMILQF-------------------------LT-LALVT-G-HVGGETRIIKGYECK
PHSQ-PWQVALFQ-KTRLLCGATLIAPRWLLTAAHCRKP---------------------
-----RYLVLLGEH-NLQRQDG--CEQRRMATESFPHPGFNNSLPNKDHRNDIMLVKMTS
PAVITHSVRPLTLS-PHCVAAGTDCLISGWGTTSSPQLHLPHSLRCANISIIGHKECE--
SAYPGN-ITDTMLCASVRKGGKDSCQGDSGGPLVCDGSLQGIISWGQDPCAVTRKPGVYT
----KVCKY------VDWIHKTMKNN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------MKLG-------LT--------------L-V-LLSLLAG-HCGADTRAVGARECQ
RNSQ-PWQAGLFY-LTRQLCGATLISDRWLLTAAHCRK------P---------------
-----YLWVRLGEH-HLWQWEG--PEKLLLATDFFPHPGFNSDLSANDHNDDIMLIRLPR
KVQMSAAVQPLNLS-QSLPTVGSQCLISGWGSVSSSKLQYPMTLQCANISILDNRLCR--
WAYPGH-ISEKMLCAGLWEGGRGSCQGDSGGPLVCNGTLAGIVSGGSEPCSRPQRPAVYT
----SVCHY------RDWVQKTMEEN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------MA------MKMLTVALVLLAGAFAEEQEKLVHGGPC
HRDSHPYQAALYN----SGHLLCGG-VLIDPEWV------LTAAHCKKE-----------
KLHV---------------YLGKHNLRQSKNTE-DISVIKTVVHPGY--------NPATH
DQDIMLLRLSKPAKLSDWIQPLPLERDCGARS-PRCHILGWGKTE--QG-----------
-------VFPDTIQ-CAYVH--------IVPQ-------EKCDQAYPG-QITRNMVCAGD
PE------EGKDAC---QG---------DSGGP---------LV-CGGR-LRGLV--SWG
NV-PCGSKEKPGVYTDVCRYVSWIQRTMRGHWP---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------MKLG-------LP--------------F-A-LLSLLAG-HCGADTRTVGARECQ
RHSQ-PWQAGLFY-LTRQLCGATLISDRWLLTAAHCRK------P---------------
-----YLWVRLGEH-HLWQWEG--PEKLLLATDFFPHPGFNSDLSANDHNDDIMLIRLPR
RVQMSAAVQPLNLS-QSLPSVGSQCLISGWGSVSSSKLQYPMTLQCANISILDNKLCR--
WAYPGH-ISDKMLCAGLWEGGRGSCQGDSGGPLVCNGTLAGIVSGGSEPCSRPQRPAVYT
----SVCHY------RDWVQKTMEENSL--------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------MGAPPPV-AGWT--GLL-LLLLSSE------------------
--AWA---------------------------------------GHWRAQGSKVLQGQEC
EAHSQPWQTALFQ----GISLLCG--VLIAENWV------LTAAHCKKP-----------
KFTV---------------RLGDHSLKNKEGSEQELAVAESIPHPCYN-----RS-SEDH
SHDLMLVRLRGRVSFGPKVKPIRLPNRCAQVG-QKCTISGWGTVTSPRE-----------
-------NFPDTLN-CADVE--------IFSQ-------KKCENAYPG-QVTDGMVCAGD
S-------NGADTC---QG---------DSGGP---------LV-CDGI-LQGIT--SWG
SD-PCGRPEKPGVYTSTCRYVNWIKKTMGIRG----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------MWLLLTFSFLLASAVAQDDSDKVWRGEEC
VPHCQPWQVALFE----HGRFTGGA-SLISPQWFTRPLIFLSSPHSACC-----------
FLRV---------------RLGEHNLRKRDGPEQLRTVSRIIPHPRY--------EARNH
RHDLMLLRLTRPVRVTAEVRPVPLPARCPQAG-EACVVSGWGLGANKEPGA-TG------
-SPESQVRLPDTLH-CANIS--------IIST-------ASCNKDYAG-RLMDTMVCAGV
EG------GGTDSC---EG---------DSGGP---------LV-CGGV-LQGTV--SWG
DV-PCDTTTKPGVYTKVCSYLEWLKETMKRN-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------MF----LLLIILQALAVAIAQSQG--DHKIIGGYTC
VRNSQPWQVALQAG--PGRSLLCGG-VLLSDQWV------ITAAHCARP-----------
ILHV---------------ALGKHNIRRWEATQQLVRVVRQVPHPQY--------QPQAH
NNDLMLLKLQKKVRLGRAVKTISVASSCASPG-TPCLVSGWGTIASPVA-----------
-------RYPTALQ-CVNVN--------IMSEQA-------CHRAYPG-IITSGMVCAGV
PE------GGKDSC---QG---------DSGGP---------LV-CGGQ-LQGLV--SWG
ME-RCAMPGYPGVYTNLCNYHSWIQRTMRSN-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----MW---PLVAT-IASLTLALSGGISRDYPKIL------NG-TNGTSGFLPGGYTCL
PHSQ-PWQAALLI-RGRLLCGGVLVHPKWVLTAAHCRKD---------------------
-----GYTVHLGKH-ALGRVE--NGEQAMEVVRSIPHPEYQVTPTHLNHDHDIMLLELKS
PVQLSSHVRTLKLSADDCLPTGTCCRVSGWGTTTSPQVNYPKTLQCANIELRSDEECR--
QVYPGK-ITANMLCAGTKEGGKDSCEGDSGGPLICNGKLYGIISWGDFPCGQPNRPGVYT
----RVSKY------LRWIWQIIRNTPEQ--RQTKGTQ----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------MGRPRP-RAAKTWMFLLLLGEAWC-VDAWTSL--TKLYVENLL
CVHLN--------------------P------QGWRSNPLPPAAGHSRAQENKVLGGQEC
RPHSQPWQAALFQ----GKQLLCGG-VLIGGNWI------LTAAHCKKP-----------
KYTV---------------RLGDHSLQKKDGPEQEIPVVQSIPHPCYN-----SSDVEDH
NHDLMLLQLRDQASLGPKVKPISLADHCTQPG-QTCIISGWGTVTSPRE-----------
-------NFPDTLN-CAEVK--------IFPQ-------KKCEDAYPG-QITDGMVCAGS
S-------KGADTC---QG---------DSGGP---------LV-CNGA-LQGIT--SWG
SD-PCGRSDRPGVYTNICRYLDWIKKTIGSKG----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------Q-VSDKGLESEEC
APHSQPWQVALYE----RGRFNCGA-SLISPHWV------LTAAHCQTS-----------
FMRA---------------HLGEHNLHKREGPEQLRLVSLAIPHPRY--------EARSH
RHDVMLLRLARPARLTPQVRPVALPVHCPQPG-EPCVVSGWGLVSGDKPGT-TG------
-SPESQVTVPDTLH-CANIS--------VISR-------AACDKDYPG-RLMDTMVCAAA
EG------GGTDSC---EG---------DSGGP---------LI-CGGA-LQGIV--SWG
DV-PCDTTAKAGVYTKVCRYLQWIRETIRRN-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------MPMKMLT------MKMLALCLVLAKSAWSEEQEKVVHGGPC
LKDSHPFQAALYT----SGHLLCGG-VLIDPQWV------LTAAHCKKP-----------
NLEV---------------ILGKHNLRQTETSQRQISVDRTIVHPRY--------NPETH
DNDIMMVHLKNPVKFSKKIQPLPLKNDCSEEN-PNCQILGWGKME--NG-----------
-------DFPDTIQ-CADVH--------LVLR-------EQCERAYPG-KITQSMVCAGD
MK------EGNDSC---QG---------DSGGP---------LV-CGGR-LRGLV--SWG
DM-PCGSKEKPGVYTDVCTYIRWIQNILRNKWL---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------MKLG--------L--------------LCF-LLSLLAG-HGWADTRAIGAEECR
PNSQ-PWQAGLFH-LTRLFCGATLISDRWLLTAAHCHK------P---------------
-----YLWVRLGEH-HLWKWEG--PEQLFRVTDFFPHPGFNKDLSANDHNDDIMLIRLPR
QARLSPAVQPLNLS-QTCVSPGMQCLISGWGAVTSPKALFPVTLQCANISILENKLCH--
WAYPGH-ISDSMLCAGLWEGGRGSCQGDSGGPLVCNGTLAGVVSGGGEPCSRPRQPAVYT
----SVCHY------LDWIQETMEN-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------M----RK
LRWLEGWKSSGSGYP---------------A-----------------LKTCPVP-----
FQAMRILRL-------------------------IT-LALVT-G-HVGAETRIIKGHPCS
PHSQ-PWQVALFQ-KTRLLCGATLIAPSWLLTAAHCYKP---------------------
-----DYVALLGEY-DLHREDG--YEQRQKATKSFRHPGFNDSLPNKDHRNDIMLIKLPK
AATITRAVRPLALP-SQCVSPGTNCLISGWGTISSPQLRLPKILRCANISIIKHEECE--
RAYPSN-ITDTMVCASVQ-EGKDSCQGDSGGPLVCNGSLQGIISWGQDPCAVSRKPGVYT
----KVCKY------VDWIQKTIRNN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------MA------VKMLVVALVLVAAAQAEEQNKVLHGGPC
EQTSHPYQAALYT----SGHLLCGG-VLIHPLWV------LTAAHCKKP----------S
NLQV---------------YLGKHNLQQRELFQEESPVIRTVVHPGY--------NAATH
DQDIMLLRLSQPARFSEHIQPLALERDCSANH-TSCHILGWGKMA--DG-----------
-------EYPNTIQ-CAYIH--------LVSR-------EECEHAYPG-QITQNMVCAGD
EK------HGKDSC---QG---------DSGGP---------LV-CGDR-LRGLV--SWG
NV-PCGSKEKPGVYTDVCRYGHWIQRVIQAN-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------MWLLLAFVLLVVS--AAQDGDKVLEGEEC
VPHSQPWQVALFE----RGRFNCGA-ILISPRWV------LTAAHCQTR-----------
FMRV---------------RLGEHNLRKHDGPEQVRTVSRIIPHPRY--------EARTH
RHDIMLLRLLQPARLSSQVRPVPLPTRCPFTG-EDCVVSGWGLLSNNKPGA-TE------
-SHKSQVRLPDTLH-CANIS--------IISE-------ASCNKDYPG-RVLPTMVCAGV
EG------GGTDSC---EG---------DSGGP---------LV-CRGA-LQGIV--SWG
DV-PCDTTTKPGVYTKVCSYLKWIRENMNRN-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------FPLSGAV------MKRLIVALALIATAGAEEQDKVVHGGPC
D-NPHPYQAALYT----SGHLLCGG-VLIHPLWV------LTAAHCKKP-----------
NLQV---------------YLGKHNLRQRESSQEQSSVVRAIIHPGY--------DAATH
DEDIMLLRLAHRAKLSEHIQPLLLERDCSANH-TSCHILGWGKTA--DG-----------
-------DYPDTIQ-CAYIH--------LVPR-------DECERAYPG-QITQNMVCAGD
EK------YGKDSC---QG---------DSGGP---------LV-CGDR-LRGIV--SWG
NV-PCGSKEKPGVYTNVCRYNNWIRKTIQAN-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------MGRPRP-RAAKTWMFLLLLGEAWC-VDAWTSL--TKLYAENLL
CVHLN--------------------P------QGWRSNPLPPAAGHSRAQEDKVLGGQEC
RPHSQPWQAALFQ----GKQLLCGG-VLIGGNWI------LTAAHCKKP-----------
KYTV---------------RLGDHSLQKKDGPEQEIPVVQSIPHPCYN-----SSDVEDH
NHDLMLLQLRDQASLGPKVKPISLADHCTQPG-QTCIISGWGTVTSPRE-----------
-------NFPDTLN-CAEVK--------IFPQ-------KKCEDAYPG-QITDGMVCAGS
S-------KGADTC---QG---------DSGGP---------LV-CNGA-LQGIT--SWG
SD-PCGRSDRPGVYTNICRYLDWIKKTIGSKG----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------MSLR---------------------------------------------
-----------VLGSG-TWPSAPKMF----LLLTALQVLAIAMTRSQE-DENKIIGGYTC
TRSSQPWQAALLAG--PRRRFLCGG-ALLSDQWV------ITAAHCGRP-----------
ILQV---------------ALGKHNLRRWEATQQVLRVVRQVTHPNY--------NSRTH
DNDLMLLRLQQPARIGRAVRPIEVTQACASPG-TSCRVSGWGTISSPIA-----------
-------RYPASLQ-CVNIN--------VSPDEV-------CQKAYPR-TITPGMVCAGV
PQ------GGKDSC---QG---------DSGGP---------LV-CRGQ-LQGLV--SWG
ME-RCALPGYPGVYTNLCKYRSWIEETMRDK-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----MW---PLALA-IASLTVALSGGISQESSKIL------N--NNGTSGFLPGGYTCF
PHSQ-PWQAALLV-QGRLLCGGVLVHSKWVLTAAHCLKE---------------------
-----GLKVYLGKH-ALGRVE--AGEQVREVVRSVPHPEYRSSPTHLNHDHDIMLLELQS
PVQLTGYIQTLPLSHNNCIIPGTTCRVSGWGTTTSPQVSYPKTLQCANIQLRSDEECH--
RVYPGK-ITANMLCAGTKEGGKDSCEGDSGGPLVCNRTLYGIISWGDFPCGQPDRPGVYT
----RVSRY------ILWIRETIRKYETQQQKWTKGPK----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------M----RR
PRRLKS---DWKLST---------------E--------------PREPGARPAL-----
LQAMMILRF-------------------------IA-LALVT-G-HVGGETRIIKGYECR
PHSQ-PWQVALFQ-KTRLLCGATLIAPKWLLTAAHCRKP---------------------
-----HYVILLGEH-NLEKTDG--CEQRRMATESFPHPGFNNSLPNKDHRNDIMLVKMSS
PAFITRAVRPLTLS-SLCVTAGTSCLISGWGTTSSPQLRLPHSLRCANVSIIGHKECE--
RAYPGN-ITDTMLCASVRKEGKDSCQGDSGGPLVCNGSLQGIISWGQDPCAVTRKPGVYT
----KVCKY------FDWIHEVMRNN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------MWLLLAFVLLVSA--A-QDGDKVLEGEEC
VPHSQPWQVALFE----RGRFNCGA-FLISPRWV------LTAAHCQTR-----------
FMRV---------------RLGEHNLRKFDGPEQLRSVSRIIPHPGY--------EARTH
RHDIMLLRLFKPARLTAYVRPVALPRRCPLIG-EDCVVSGWGLLSDNNPGA-TG------
-SQKSHVRLPDTLH-CANIS--------IISE-------ASCNKDYPG-RVLPTMVCAGV
EG------GGTDSC---EG---------DSGGP---------LV-CGGA-LQGIV--SWG
DV-PCDTTTKPGVYTKVCSYLEWIWENVRRY-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------VAMKTT------VKMLALCLVLVKSAWTEEQDKVVHGAPC
LKNSHPFQAALYT----SGHLLCGG-VLVDPQWV------LTAAHCKKP-----------
NLEV---------------RLGKHNLRQTESFQRHISVDRTIVHPRY--------NPDTH
DNDIMMLHLRNSVKFSQKIQPLPLKKDCSKES-RSCQILGWGKME--NG-----------
-------DFPDTLQ-CADVQ--------LVSR-------EECERAYPG-KITRSMVCAGD
KE------EGSDSC---QG---------DSGGP---------LV-CGDR-LRGLV--SWG
NL-PCGSKKKPGVYTDVCFHTKWIQNIIKTKWL---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------MKLG--------L--------------LCA-LLSLLAG-HGRADTRAIGAEECR
PNSQ-PWQAGLFH-LTRLFCGATLISDRWLLTAAHCHK------P---------------
-----YLWVRLGEH-HLWKWEG--PEQLFRVTDFFPHPGFNKDLSANDHNDDIMLIRLPR
QARLSPAVQPLNLS-QTCVSPGTQCLISGWGAVTSPKALFPVTLQCANISILENKLCH--
WAYPGH-ISDSMLCAGLWEGGRGSCQGDSGGPLVCNGTLAGVVSGGGEPCSRPRHPAVYT
----SVCHY------LDWIQATMEN-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------M----RR
PGRLKS---DWKLST---------------V--------------PREPGARPAL-----
LQAMVILRF-------------------------IT-LALVT-G-LVGGETRIIKGYECT
PHSQ-PWQVALFQ-KTRLLCGATLINPKWLLTAAHCRKP---------------------
-----RYVILLGEH-NLEKTDG--YEQKRMATESFPHPGFNNSLPNKDHRNDIMLVKMSS
PAILTRAVQPLTLS-SHCVTAGTSCLISGWGTTSSPQLRLPHSLRCANVSIIEHKECE--
NAYPGN-ITETMLCASVRKEGKDSCQGDSGGPLVCNGSLQGIISWGQDPCAVTRKPGVYT
----KVCKY------TDWIYEIMKNN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------GIPQDHPKII------NS-TNGTNGFLPGGYTCP
PHSQ-PWQAALLV-QGRLLCGAVLVHPRWVLTAAHCLKD---------------------
-----GYRVSLGKH-TLGHEE--AGEQVRDVARSIPHPLYRSSPTHLNHDHDIMLLELQS
PVRLSSHIRVLPLSHSDCLPAGTCCRVSGWGTTISPRVSFPQALQCANLQLRSDEECR--
QAYPGR-ITRNMVCAGSPEGGKDSCEGDSGGPLVCNGRLHGIISWGDFPCGQPNRPGVYT
----RVSQY------ISWIQETIRGQRPREQEWTKGPQ----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------LAEDKDKVVHGGPC
EKDSHPFQATLYT----SGHLLCGG-VLIHPLWV------LTAAHCDKP-----------
NLQV---------------YLGKHNLRQRENFQKRISVNRTVVHPHY--------NPTTH
DNDIMMVRLRFPARLSKTIQPLPLKRDCSQEN-PSCRILGWGKMR--DG-----------
-------DFPDTIQ-CAEVQ--------LVPH-------EECERAYPG-KITQNMLCAGD
RR------DGNDSC---QG---------DSGGP---------LV-CGDH-LRGLV--SWG
NI-PCGSKTKPGVYTDVCNYDKWIQNTIGHNA----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------MKKLMVVLSLIAAAWAEEQNKLVHGGPC
DKTSHPYQAALYT----SGHLLCGG-VLIHPLWV------LTAAHCKKP-----------
NLQV---------------FLGKHNLRQRESSQEQSSVVRAVIHPGY--------DAATH
DQDIMLLRLARPAKLSELIQPLPLERDCSANT-TSCHILGWGKTA--DG-----------
-------DFPDTIQ-CAYIH--------LVPR-------EECERAYPG-QITQNMLCAGD
EK------YGKDSC---QG---------DSGGP---------LV-CGDH-LRGLV--SWG
NI-PCGSKEKPGVYTNVCRYTNWIQKTIQAK-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------MWTVLL---LLLLA------------------
--SWA---------------------------------------GHTEAQGNKVLQGQEC
EPHSQPWQTALFQ----GERLLCGG-VLVGSRWV------LSAAHCKKT-----------
KYTV---------------RLGDHSLQSKDEPEQEISVAQSIQYPCYN-----NSNNEDH
SHDLMLIRLRKQASLGPKVKPIDLAEHCAKAG-QKCTISGWGTVSSPRE-----------
-------NFPDTLN-CAEVE--------IFSL-------KKCEKAYPG-QVTAGMICAGN
S-------NGADTC---QG---------DSGGP---------LV-CDGI-LQGIT--SWG
SD-PCGKPDKPGVYTSICRYHKWIKKTMGNRV----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------ISREYPKIL------NG-TNGTSGFLPGGYTCL
PHSQ-PWQVALLV-KGRLLCGGVLVHPKWVLTAAHCLKV---------------------
-----GYTVHLGKH-VLGRVE--THEQVRAVARSVPHPKYQVSPTHLNHDNDIMLLELET
PVQLTGHIRTLPLSRSDCLPPGTCCRVSGWGTTTSPQVSYPKTLQCANIPLRSDEECR--
HVYPGK-ITTNMLCAGTKEGGKDSCEGDSGGPLVCNNTLHGIISWGDFPCGQPNRPGVYT
----RVSRY------VSWIHETIKDHKTREQKRTKSTQ----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------CTRS-------------------
-----GYRVYLGKH-ALGRVE--TGEQVREVVRSIPHPEYQVSPTHLNHDHDIMLLELEA
PVQPTGHIRILPLSHDNCLPAGTCCLVSGWGTTTSPQVSYPKTLQCANIQLRSDEECR--
QVYPGK-ITPNMLCAGTQEGGKDSCEGDSGGPLVCNGTLHGIISWGDFPCGQPNRPGVYT
----RVPQY------VQWIRDTIRKHKAQGQKWTKGTD----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---MPLLTL-------------------------MV-LALV-TG-RGRAETRIIKGYECP
AHSQ-PWQVALFQ-KSRLHCGATLINRQWLLTAAHCKKP---------------------
-----QYWVYLGEH-NLQRPDS--CEQKRMATLSFPHPGFNGSLPNKDHRNDIMLVKMNS
PVMLTRGVKPLALP-EDCATAGSQCLISGWGTTTSPQLTLPHTLRCANITLIDHRECE--
GAYPGN-ITDTMVCAGVTKEGKDSCQGDSGGPLVCNGTLQGIISWGQDPCAVSRKPGVYT
----KVCKY------VDWIHETIKDNSP--------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------ML----LLLTILQALAVAIVQSQG--DDKILGGYTC
VQNSQPWQVALQAG--PGRRFLCGG-VLLSDQWV------ITAAHCARP-----------
LLHV---------------ALGKHNLRRWEATQQVLRVVRQVPHPQY--------RPQAH
DNDLMLLKLQRKVRLGRAVRTIPVARSCASPG-TPCRVSGWGTTASPIV-----------
-------RYPTALQ-CVNVN--------IMPEQV-------CHRAYPG-TITSGMVCAGV
PE------GGKDSC---QG---------DSGGP---------LV-CQGQ-LQGLV--SWG
ME-RCAMPGYPGVYTNLCNYHSWIQRTMQSN-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------MWLLLTLSFLLASSAAQ-DGDKLLEGDEC
TPHSQPWQVALYE----RGRFNCGA-SLISPHWV------LSAAHCQTR-----------
FMRV---------------RLGEHNLRKRDGPEQLRTASRVIPHPRY--------EARSH
RHDIMLLRLVQPARLTPQVRPVVLPTRCPHPG-EACVVSGWGLVSHIEPGT-TR------
-SPQSQVSLPDTLH-CANIS--------IISD-------TSCDKSYPG-RLTNTMVCAGA
EG------RGAESC---EG---------DSGGP---------LV-CGGV-LQGIV--SWG
DV-PCDNTTKPGVYTKVCHYLKWIRETMKRN-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------MSLR---------------------------------------------
-----------VLGSG-TWPSAPKMF----LLLTALQVLAIAMTQSQE-DENKIIGGHTC
TRSSQPWQAALLAG--PRRRFLCGG-ALLSGQWV------ITAAHCGRP-----------
ILQV---------------ALGKHNLRRWEATQQVLRVVRQVTHPNY--------NSRTH
DNDLMLLQLQQPARIGRAVRPIEVTQACASPG-TSCRVSGWGTISSPIA-----------
-------RYPASLQ-CVNIN--------ISPDEV-------CQKAYPR-TITPGMVCAGV
PQ------GGKDSC---QG---------DSGGP---------LV-CRGQ-LQGLV--SWG
ME-RCALPGYPGVYTNLCKYRSWIEETMRDK-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
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----MLIRLRGQASLGPKVKPINLADKCAHVG-QKCTISGWGTVTSPRE-----------
-------NFPDTLN-CAEVQ--------IFSQ-------NKCEDAYPG-QVSDGMICAGN
S-------NGADTC---QG---------DSGGP---------LV-CDGL-LQGIT--SWG
SD-PCGRPDRPGVYTNVCRYLDWIKKTMGKRG----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------MSLR---------------------------------------------
-----------VLGSG-TWPSAPKMF----LLLTALQVLAIDMTRSQE-DENKIIGGYTC
TRSSQPWQAALLAG--PGRRFLCGG-ALLSDQWV------ITAAHCGRP-----------
ILQV---------------ALGKHNLRRWEATQQVLRVVRQVTHPNY--------NSRTH
ENDLMLLRLQQPARIGRAVRPIEVAQACASPG-TSCRVSGWGTISSPIA-----------
-------RYPASLQ-CVNIN--------ISPDEV-------CQKAYSK-AITPGMVCAGV
PQ------GGKDSC---QG---------DSGGP---------LV-CRGQ-LQGLV--SWG
ME-RCALPGYPGVYTNLCKYRSWIEETMRHK-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---MRILWL-------------------------IT-LALVT-G-HVGGETRIIKGYPCL
PHSQ-PWQVALFQ-KTRLLCGATLIGPQWLLTAAHCRKP---------------------
-----HYRVLLGEH-NLNREDG--CEQRQTATESFPHPDFNNSLPNKDHRNDIMLVKLPR
PAVITQAVRPLSLP-SHCVTAGTNCLISGWGTTSSPQLHLPHTLRCTNISIMKHEECE--
RAYPGN-ITDTMVCASVRQEGKDSCQGDSGGPLVCNQSLQGIISWGQDPCAVSRKPGVYT
----KVCKY------VDWIQKIMHNN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----MW---PLALV-IASLTAALSG----------------------------GGYTCF
PQ---------------------------VLTAAHCLND---------------------
-----GLKVYLGKH-ALGRVE--AGEQVREVVHSIPHPAYRRSPTHSNHDHDVMLLELQS
LAQLTGYIQTLPLSHNNYLTPGTTCQVSGGGTTTSPQVNYSKTLQCANIQLGSDEECH--
QVYPGK-ITDNMLCASTKEGGKDSREGDSGGPLVCNRTLYGTISWGDFPCGQPD------
-------QY------VLWIRETVRKYETQQQKWLKGPQ----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------MRLG--------F--------------ICA-LLSLLEG-QSWADTRAIGGKECR
PNSQ-PWQVGLFF-LTRLFCGATLISDRWLLTAAHCRK------P---------------
-----FLWVRLGEH-HLWKWEG--TEQLFWATDFFPHPGFNKDLSAHDHNDDIMLIRLPR
KALLGPAVQPLKLS-RTCVSPGTQCLISGWGATSSPKVQYPLTLQCATISILEPKLCQ--
RAYPGH-ILYRMLCAGLWEGGRGPCQGDSGGPLVCNGALAGVVSGGSEPCSRPQRPAVYT
----SVCRY------LDWIRKTMEDN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------MGHPTA-AAVWIMFPL-LPLESRAAS-ASW----EANTEGGCV
CICLKPQW-FSWPL---------H-P------SGW-SNPLSPAAGHLRAQETEVLEGQEC
RPRYQPWQTAFLQ----GVQLICGD-VLIDDHCI------LTAAH---------------
NYTV---------------RLGDHGLQNEDGSEQETAVAQSIPHPCYN-----SS-NKDH
NHDLLLIPC-ERASLGPKVKPINLADHCPQVG-QKCTISSWSSVTSPQE-----------
-------NFPDTLN-CTEVE--------IIPQ-------KQCEDAYPG-QVTDSMVCANE
S-------SGADTC---Q------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------MKTLIVTLILVAAAQTEEQNKVLHGGPC
EQTSHPYQAALYA----SGHLLCGG-VLIHPLWV------LTAAHCKKP-----------
NLQV---------------YLGKHNLQQRESFQEESSVVRTVVHPGY--------NPATH
DQDIMLLRLSRPAKFSAHIQPLSLERDCAANH-TSCHILGWGKTA--DG-----------
-------DFPNIIQ-CAYLH--------LVPR-------EECERAYPG-EITQNMVCAGD
EK------LGKDSC---QG---------DSGGP---------LV-CGDR-LRGLV--SWG
NV-PCGSKEKPGVYTDVCRYGHWIRKTIQAN-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------MWLLLPLSFLLASTAAQ-DGDKLLEGEEC
APHSQPWQVALYE----RGRFNCGA-SLISPHWV------LSAAHCQSR-----------
FMRV---------------RLGEHNLRKRDGPEQLRTASRVIPHPRY--------EARSH
RHDIMLLRLVRPARLTPQVRPVVLPTRCPHPG-EACVVSGWGLVSHNEPGT-TG------
-SPQSQVNLPDTLH-CANIS--------IISD-------ASCDKNYPG-RLTNTMVCAGA
EG------RGAESC---EG---------DSGGP---------LV-CGGI-LQGIV--SWG
DV-PCDNTTKPGVYTKVCRYVKWIRETMKRN-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------MA------AKRLALTLALVMAAWAEEQNKVVHGGPC
NQTSHPFQAALFT----AGHLLCGG-VLIHPQWV------LTAAHCKKP-----------
NLQV---------------FLGKHNLQQQERAQHQSSVVQTVTHPGY--------NAAAH
DQDIMLLRLKHPVTLSKSIQPLALERDCSADQ-TSCYILGWGKTA--DG-----------
-------HFPDTIQ-CAYIH--------LVPR-------GECERAFPG-QITKNMLCAGD
EK------YGKDSC---QG---------DSGGP---------LV-CGGR-LRGLV--SWG
NL-PCGSKEKPGVYTNVCRYFNWIQKTIRTK-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------MKLG--------L--------------LCA-LLSLLAG-HGWADTRAIGAEECR
PNSQ-PWQAGLFH-LTRLFCGATLISDRWLLTAAHCRK------P---------------
-----YLWVRLGEH-HLWKWEG--PEQLFRVTDFFPLS----------------------
------------------------LCLPGWSALSSLTALFPVTLQCANISILENKLCH--
WAYPGH-ISDSMLCAGLWEGGRGSCQGDSGGPLVCNGTLAGVVSGGAEPCSRPRRPAVYT
----SVCHY------LDWIQEIMEN-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------MKKLMVVLSLIAAAWAEEQNKLVHGGPC
DKTSHPYQAALYT----SGHLLCGG-VLIHPLWV------LTAAHCKKP-----------
NLQV---------------FLGKHNLRQRESSQEQSSVVRAVIHPDY--------DAASH
DQDIMLLRLARPAKLSELIQPLPLERDCSANT-TSCHILGWGKTA--DG-----------
-------DFPDTIQ-CAYIH--------LVPR-------EECERAYPG-QITQNMLCAGD
EK------YGKDSC---QG---------DSGGP---------LV-CGDH-LRGLV--SWG
NI-PCGSKEKPGVYTNVCRYTNWIQKTIQAK-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----MW---PLALV-IASLTVALSGGISQESSKVL------N--TNGTSGFLPGGYTCF
PHSQ-PWQAALLV-QGRLLCGGVLVHPKWVLTAAHCLKE---------------------
-----GLKVYLGKH-ALGRVE--AGEQVREVVYSIPHPEYRRSPTHLNHDHDIMLLELQS
PVQLTGYIQTLSLSHNNRLTPGTTCRVSGWGTTTSPQVNYPKTLQCANIQLRSDEECR--
QVYPGK-ITDNMLCAGTKEGGKDSCEGDSGGPLVCNRTLYGIISWGDFPCGQPDRPGVYT
----RVSRY------ILWIRETIRKYETQQQKWLKGPQ----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------MFL----MLMALQILAVAVAQNQG-DE-KIIGGYTC
IRSSQPWQAALLQG--PQRRFLCGG-SLLSDQWV------ITAAHCARL-----------
ILRV---------------ALGKHNLKIPEATQQVLRVVRQVPHPQY--------NSRTN
DNDLMLLQLERPARLGPGVRPISVAS----AP-TSCLVWGWGTTSSPIA-----------
-------RYPNSLQ-CVDIN--------IFSDQE-------CRRAYSS-AITPGMVCAGV
PQ------GRKDSC---QG---------DSGGP---------LV-CGGQ-LQGLV--SWG
ME-RCAQPGYPGVYTNLCKYHTWIQRTIQRR-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------ML----LLLTALQVLAVAMVQSQE-DDNKIIGGYTC
IQNSQPWQVALLAG--PGRRFRCGG-ALLSDQWV------ITAAHCAHS-----------
TLHV---------------ALGKHNLRRWEATQQIVRVVRQVPYPQY--------QPRAH
NNDLMLLKLQRRARLGRAVRPITLASACASPG-TACRVSGWGTTSSPIA-----------
-------KYPTALQ-CVNVN--------IMSEQV-------CRQAYSG-AITSGMVCAGV
PE------GGKDSC---QG---------DSGGP---------LV-CGGK-LQGLV--SWG
ME-RCAMPGYPGVYTNLCNYHDWVQRTMQRN-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------MWLLFTFFVL-AS--TAQDGGKVLEDEEC
VPHSQPWQVALFE----HTRFNCGA-SLISPLWV------LSAAHCQTR-----------
FMRV---------------RLGEHNLRKYDGPEQLLAVSRIIPHPGY--------EARSH
LHDIMLLRLLRPVRLTPQVRPLALPTRCPRVG-EPCLVSGWGLISDNGPEN-PK------
-RPKPQVRLPDTLH-CANIS--------IISD-------ASCDKDYPG-RVMDTMVCAGV
EG------RGTDSC---EG---------DSGGP---------LV-CTGA-LQGIV--SWG
DV-PCDTTTKPGVYTKVCYYLKWIRETMKRN-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------MFL----LLTALQILAVATAQSQG-NENKIIGGYTC
IRNSQPWQAALLAG--PWHRFLCGG-ALLSDQWV------ITAAHCARP-----------
ILRV---------------ALGKHNLRTREAAQQVLRVVRQVPHPQY--------NSRTH
DNDLMLLQLERAARLGRTARPIAVASSCASPG-TPCRVSGWGTISSPIA-----------
-------RYPNSLQ-CVNIN--------VSPDQE-------CRQAYRG-AITPGMVCAGV
PQ------GGKDSC---QG---------DSGGP---------LV-CREQ-LQGLV--SWG
ME-RCAQPGYPGVYTNLCKYQAWIQETMQGRS----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MKLAVVLIVLAAAWAEEQDKVVHGGPC
ENTSHPYQAALYT----SGHLLCGG-VLIHPQWV------LTAAHCRKX----------X
XXXXXXXXXXXXXXX---------------XXXXXXXXXXXXXXXXX--------XXXXX
XXXXXX--XXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXX-XXX-----------
-------NFPDTIQ-CAYIH--------LVPR-------DKCERAYPG-QITRNMVCAGD
EK------FGRDSC---QG---------DSGGP---------LV-CGDR-LRGLV--SWG
NV-PCGSKEKPGVYTDVCRYISWIQRTIYTH-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------MKL--------VF--------------AGA-LLSLLAG-HSWADTRAIGAKECP
RNSQ-PWQAGLFF-LGRLFCGATLISDRWLLTAAHCRK------S---------------
-----HLWVRLGEH-HLWQWEG--PEQLFLARDFFPHPGFNSDLSANDHNHDIMLIRLPR
RARLGPAVRPLNVS-ETCVSPGTKCLISGWGAVSSPKVQFPLTLQCANISILEPTLCH--
WAYPGH-ISDTMICAGQWEGGRGSCRGDSGGPLVCNGALAGVVSGGSEPCSRPRRPAVYT
----GACHY------YDWIRKTIEEN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------MKLA--------L--------------VCS-LLSLLAX-XXXXXXXXXXXXXXX
-XXX-XXXXXXXX-XXXXXXXXXXISDRWLLTAAHCRQ------R---------------
-----YLWVRLGEH-HLWLWEG--PEQLFRVTDFFPHPGFNDDLSAQDHNDDIMLIRLPR
KARIGPAVKPLNLS-ETCVSPGAHCLISGWGAVSSPKVEYPKTLQCANISILEPILCH--
IAYPGH-ISYKMLCAGQWEGGRGSCQGDSGGP----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----MW---SLAAA-IACLTVALSGGISRDYPKIL------NG-TNGTSGFLPGGYTCL
PHSQ-PWQAALLV-RGLLLCGGVLVHPKWVLTAAHCMKD---------------------
-----GYTVHLGKH-VLGRVE--THEQVREVIHSIPHPAYQVSPTHLNHDNDIMLLELET
PVQLTGYVRTLPLSRSDCLPPGTCCRVSGWGTTTSPQVSYPKTLQCANIPLRSDAECR--
GVYPGK-ITTNMLCAGTKEGGKDSCEGDSGGPLVCNNTLHGIISWGDFPCGQPNRPGVYT
----RVSRY------VPWIHETIKNHKAQEKKWTKGAQ----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------M----QR
LRRLQDWKSSGRGLA---------------A--------------AKEPGARPSP-----
LQAMRILQL-------------------------IM-LALAT-G-LVGGETRIIKGFECK
PHSQ-PWQAALFE-KTRLLCGATLIAPSWLLTAAHCRKP---------------------
-----RYIVHLGEH-NLQKQDG--CEQTRTATESFPHPGFNNSLPNKDHRNDIMLVKMAS
PAFITWAVQPLTLS-SRCVTAGTSCLISGWGSTSSPQLRLPHSLRCANITIIEHQKCE--
NAYPSN-ITDTMVCASVQEGGKDSCQGDSGGPLVCNHSLQGIISWGQDPCAITRKPGVYT
----KVCKY------VDWIQETMKNN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------MKL--------GF--------------TWA-LLSLLAG-HSWADIRAIGAKECA
RNSQ-PWQAGLFF-LTRLFCGATLISDRWLLTAAHCRK------P---------------
-----YLWVRLGEH-HLWQWEG--PEKLFLATEFFPHPGFNKDLTANDHNHDIMLIRLPR
RARLGPAVQPLNIS-TTCVSPGTKCLISGWGAVSSPKVKFPLTLQCADITILEPMLCH--
WAYPGH-ISDNMICAGRWEGGLGSCQGDSGGPLVCNGALAGVVSGGGEPCSKPRRPTVYT
----SVCHY------NDWIRKTMEENSS--------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------QGAF----LL
HWQLKT---EW--AQ---------------E--------------PWEPGACPAL-----
LQAMMILRL-------------------------IA-LALVT-G-HVGGETRIIKGYECA
PHSQ-PWQVALFQ-KTRLLCGATLIAPKWLLTAAHCRKP---------------------
-----RYVILLGEH-NLEKTDG--YEQKRMATESFPHPGFNNSLPNKDHRNDIMLVKMSS
PAIITRAVQPLTLS-SHCVTAGTSCLISGWGTTSSPQLRLPHSLRCANVSIIEHKECE--
SAYPGN-ITETMLCASVRKEGKDSCQGDSGGPLVCNRSLQGIISWGQDPCAVTRKPGVYT
----KVCKY------IDWIYETMRNN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------QPCIFD----RSRYNCGA-TLISQRWV------LTAAHCHT-----------G
PIHV---------------RLGKYNLYTREGSEQHRAVAKALIHPGY--------NCTDH
NNDIMLLKLHTPAALNRYVQPLGLASRCAEPG-KQCSISGWSNAINAQE-----------
-------NVSVILY-CSTVH--------TISD-------EQCAADFPG-HVNGNMLCAGL
RG------GGTDSC---EG---------DSGGP---------LV-CDGK-LQGVV--SWG
DV-PCLSTLKPGVYMNVCKYYNWLLATMWAN-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------LLL--THMFMYVELSQGNDKVLGGEEC
PPHSQPWQVALFE----GRRFNCGA-SLISSQWL------LTAAHCYT-----------S
KMRV---------------RLGEHNLRVWDGMEQLRGVVYAFPHPRY--------QGHGH
HDDIMLLRLARPASLSDSVQPVALPVRCPRTG-EQCVVSGWGLVAESNNKTQRG------
LAPVPKVKLPDTLH-CANIS--------IISA-------ASCNRDYPG-QVTDTMVCAGV
EG------GGTDSC---EG---------DSGGP---------LV-CGGT-LQGIV--SWG
DV-PCDTTTKPGVYTKVCKYLTWIRDTMKNN-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------M----QR
LRWLQDGKSSGRGLA---------------A--------------AKEPGARPSP-----
LQAMRILQL-------------------------IM-LALVT-G-LAAGETRIIKGFECK
PHSQ-PWQAALFE-KTRLLCGATLIAPRWLLTAAHCRKP---------------------
-----RYIVHLGEH-NLQRRDG--CEQTRTATESFPHPGFNNSLPNKDHRNDIMLVKMAS
PAFITWAVRPLTLS-SRCVTAGTSCLISGWGSTSSPQLRLPHSLRCANITIIEHHECE--
HAYPNN-ITDTMVCASVQEGGKDSCQGDSGGPLVCNHSLQGIISWGQDPCAITRKPGVYT
----KVCKY------VDWIHETMSNN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------M----QR
LRWLQDWKSSGRGLA---------------A--------------AKEPGARPSP-----
LQAMRILQL-------------------------IM-LALAT-G-LVGGETRIIKGFECK
PHSQ-PWQAALFE-KTRLLCGATLIAPSWLLTAAHCRKP---------------------
-----RYIVHLGEH-NLQKQDG--CEQTRTATESFPHPGFNNSLPNKDHRNDIMLVKMAS
PAFITWAVRPLTLS-SRCVTAGTSCLISGWGSTSSPQLRLPHSLRCANITIIEHQKCE--
NAYPNN-ITDTMVCASVQEGGKDSCQGDSGGPLVCNHSLQGIISWGQDPCAITRKPGVYT
----KVCKY------VDWIQETMKNN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------

------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
-----------MSLR---------------------------------------------
-----------VLGSG-TWPSAPKMF----LLLTALQVLAIDMTRSQE-DENKIIGGYTC
TRSSQPWQAALLAG--PGRRFLCGG-ALLSDQWV------ITAAHCGRP-----------
ILQV---------------ALGKHDLRRWEATQQVLRVVRQVTHPNY--------NSRTH
ENDLMLLRLQQPARIGRAARPIEVAQACASPG-TSCRVSGWGTISSPIA-----------
-------RYPASLQ-CVNIN--------ISPDEV-------CQKAYSK-AITPGMVCAGV
PQ------GGKDSC---QG---------DSGGP---------LV-CRGQ-LQGLV--SWG
ME-RCALPGYPGVYTNLCKYRSWIEETMRHK-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------FAEEQEKLVHGGPC
DRDSHPYQAALYS----SGHLLCGG-VLIHPEWV------LTAAHCRKE-----------
KLHV---------------YLGKHNLRQSNNTE-EISVVKTVVHPGY--------NPATH
DQDIMLLRLSKPAKLSDWIQPLPLQWDCKARS-VRCHILGWGKTE--QG-----------
-------VFPDTIQ-CAYVH--------IVSQ-------ETCDQAYPG-QITRNMVCAGD
QE------GGKDAC---QG---------DSGGP---------LV-CGNH-LRGLV--SWG
NV-PCGSKEKPGVYTDVCRYVNWIQRTI-GNWP---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------LQTSSLIQTLPPSAWAEEKNKVMHGGPC
EQTSHPYQAVLYS----SGHLLCGG-VLIHPLWV------LTAAHCKKT-----------
DLQV---------------YLGKHNLQQRESFQEQSSVVRAVAHPGY--------NPATH
DQDIMLLRLARPTRFSEHIQPLSLERDCSANH-TSCHILGWGKTA--DG-----------
-------NYPDTIQ-CAYIH--------LVSR-------EECERAYPG-QITQNMVCAGD
EK------HGKDSC---QG---------DSGGP---------LV-CGDR-LRGLV--SWG
NV-PCGSKEKPGVYTDVCRYGHWIRKTIQAN-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------MGCPRP-RAAETWMFLLLLGEAWAVCGCLDLL--TKLYAENLP
CVHLNPQW-PSQPS---------HCP------RGWRPDPVPPAAGHSRAQEDKVLGGHEC
QPHSQPWQAALFQ----GQQLLCGG-VLVGGNWV------LTAAHCKKP-----------
KYTV---------------RLGDHSLQNKDGPEQEIPVVQSIPHPCYN-----SSDVEDH
NHDLMLLQLRDQASLGPKVKPISLADHCIQPG-QKCTISGWGTVTSPRE-----------
-------NFPDTLN-CADVN--------IFPQ-------KKCEDAYPG-QITDGMVCAGS
S-------KGADTC---QG---------DSGGP---------LV-CNGA-LQGIT--SWG
SD-PCGRSDRPGVYTNICRYLDWIKKIIGSKG----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------MWLL-TFSFLLTPAAAQHHSAKTLKGEAC
EPHSQPRQAALLE----RGRFNCGV-SLTPQ------------AGCCLL-----------
FMSV---------------HLGEHNLRKRDGPEVLRTVA-----------------PRSH
RHDVMLPRLTRPTCLFPQVRPVALPTRCPQPG-KACVVSGWGLVADDKPGT-KG------
-SARSQVSLPDMLH-CANIS--------VIPA-------TSCSKDYPG-RLMSTTCAEGR
TPVRSEPWGRRTGL---GG---------DSGGPH-----TGWLV-CGGV-LQGIV--SWG
GV-PCDTTNKPGVYTKVCSYLGWIRDTTKRN-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------M----QR
LRWLQDWKSSGRGLT---------------A--------------AKEPGARSSP-----
LQAMRILHL-------------------------IM-LALVT-G-LVGGETRIIKGFECK
PHSQ-PWQAALFE-KTRLLCGATLIAPRWLLTAAHCRKP---------------------
-----RYIVHLGEH-NLQKEEG--CEQTRTATESFPHPGFNNSLPNKDHRNDIMLVKMAS
PVSITWAVRPLTLS-SRCVTAGTSCLISGWGSTSSPQLRLPHTLRCANITIIEHQKCE--
NAYPGN-ITDTMVCASVQKGDKDSCQGDSGGPLVCNESLQGIISWGQDPCAITRKPGVYT
----KVCKY------VDWIQETMKNN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----MW---PLALV-IASLTLGLSGGVSQESSKVL------N--TSGTSGFLPGGYTCF
PHSQ-PWQAALLV-QGRLLCGGVLVHPKWVLTAAHCLKE---------------------
-----GLKVYLGKH-ALGRVE--AGEQVREVVHSIPHPEYRRSPTHLNHDHDIMLLELQS
LVQLTGYIQTLPLSHNNRLTPGTTCRVSGWGTTTSPQVNYPKTLQCANIQLRSDEECR--
QVYPGK-ITDNMLCAGTKEGGKDSCEGDSGGPLVCNRTLYGIVSWGDFPCGQPDRPGVYT
----RVSRY------VLWIRETIRKYETQQQKWLKGPQ----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
---------MWPLA-----------LVIASLTVALSGVNYPKTLQCANIQLRSDEECR--
QVYPGK-ITDNMLCAGTKEGGKDSCEGDSGGPLVCNRTLYGIISWGDFPCGQPDRPGVYT
----RVSRY------VLWIRETIRKYEAQQQQWLKCPQ----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------MKKLMVVLSLIAAAWAEEQNKLVHGGPC
DKTSHPYQAALYT----SGHLLCGG-VLIHPLWV------LTAAHCKKP-----------
NLQV---------------FLGKHNLRQRESSQEQSSVVRAVIHPDY--------DAASH
DQDIMLLRLARPAKLSELIQPLPLERDCSANT-TSCHILGWGKTA--DG-----------
-------DFPDTIQ-CAYIH--------LVSH-------EECEHAYPG-QITQNMLCAGD
EK------YGKDSC---QG---------DSGGP---------LV-CGDH-LRGLV--SWG
NI-PCGSKEKPGVYTNVCRYTNWIQKTIQAK-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------FAEDHEKLVQGEPC
NQRSHPYQAALYN----SGQLICGG-VLIHPEWV------LTVAHCKKE-----------
KLHV---------------CLGKHYRRGAEGTQ-SISVAKTVVHPGF--------NPATH
DQDIMLLRLAQPANISERIHALALEENCQASA-TSCHILGWGKTE--EG-----------
-------QFPNSLQ-CAHVQ--------IVPQ-------EACERAYPH-QITRNMVCAGD
PT------HGEDAC---EG---------DSGGP---------LV-CEGL-LRGLV--SWG
EV-PCGSKEKPGVYTDVCRYVNWIRKTIQDHL----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------MWLLLTFYFLLTSAASQDDSDKMLEDEEC
APHSQPWQAALFH----RGRFNCGA-SLISPRWV------LSATHCQPR-----------
SMRV---------------RLGEHNLRKRDGPEQLRAVSRVIVHPGY--------EARGH
IHDVMLLRLIRPALISEQVRPVALPTRCPQPG-DACLVSGWGLVSGGGPRT-TG------
-SSVPQVSLPDTLH-CANIS--------VISA-------ASCNKAYPG-CLMDTMVCAGV
EG------GGTNSC---EG---------GSRGP---------LV-CGGRSCKGIV--SWG
DV-PCDTNTKPGVYTKVCRYLEWIRETMESN-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------MF----LLLAALQVLAVATAQGPE-DDNKVIGGYTC
VQNSQPWQVALLAG--PGRRFLCGG-VLLSDQWV------ITAAHCARP-----------
ILHV---------------ALGKHNLKKWEATQQVLRVERQVPHPRY--------NARTH
DSDLMLLRLSQRARIGRAVRPISLAQSCASPG-TSCRVSGWGTTSSPIA-----------
-------RYPNALQ-CVNIN--------IISSPQ-------CQRAYPN--ITAGMVCAGV
PQ------GGKDSC---QG---------DSGGP---------LV-CGGQ-LQGLV--SWG
ME-RCALPGYPGVYTNLCKYRSWIQRTEQGQ-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------MWLLLTLSFLLASTAAQ-DGDKLLEGDEC
APHSQPWQVALYE----RGRFNCGA-SLISPHWV------LSAAHCQSR-----------
FMRV---------------RLGEHNLRKRDGPEQLRTASRVIPHPRY--------EARSH
RNDVMLLRLVQPARLTPQVRPAVLPTRCPHPG-EACVVSGWGLVSHNEPGT-AG------
-SPRSQVSLPDTLH-CANIS--------IISD-------TSCDKSYPG-RLTNTMVCAGA
EG------RGAESC---EG---------DSGGP---------LV-CGGI-LQGIV--SWG
DV-PCDNTTKPGVYTKVCHYLEWIRETMKRN-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------M----QR
LRWLQDRKSSGRGLA---------------A--------------AKEPGARPSP-----
LQAMRILQL-------------------------IM-LALVT-G-LVAGETRIIKGFECK
PHSQ-PWQAALFE-KTRLLCGATLIAPRWLLTAAHCRKP---------------------
-----RYIVHLGEH-NLQRREG--CEQTRTATESFPHPGFNNSLPNKDHRNDIMLVKMAS
PASITWAVRPLTLS-SSCVTAGTSCLISGWGSTSSPQLRLPHSLRCANITIIEHQECE--
HAYPNN-ITDTMVCASVQKGGKDSCQGDSGGPLVCNHSLQGIISWGQDPCAITRKPGVYT
----KVCKY------VDWIQETMNNN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------MWLLLTLSFLLASS-AQ-DGDKLLEGDEC
TPHSQPWQVALYE----RGRFNCGA-SLISPHWV------LSAAHCQTR-----------
FMRV---------------RLGEHNLRKRDGPEQLRTASRVIPHPRY--------EARSH
RHDIMLLRLVQPARLTPQVRPVMLPTRCPHPG-EACVVSGWGLVSHIEPGT-TR------
-SPQSQVSLPDTLH-CANIS--------IISD-------TSCDKSYPG-RLTNTMVCAGA
EG------RGAESC---EG---------DSGGP---------LV-CGGV-LQGIV--SWG
DV-PCDNTTKPGVYTKVCHYLKWIRETMKRN-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----MW---PLAAA-IASLTVALSRGISRDYPKIL------NG-TNGTSGFLPGGYTCL
PHSQ-PWQAALLV-RGRLLCGGVLVHPKWVLTAAHCMKD---------------------
-----GYTVHLGKH-VLGHVE--SREQVRQVVHSIPHPEYQVSPTHLNHDNDIMLLELES
PVQLTGSVRTLPLSRSNCLPPGTCCRVSGWGTTTSPQVSYPKTLQCANIPLRSDEECR--
RVYPGK-ITTNMLCAGTKEGGKDSCEGDSGGPLVCNNTLYGIISWGDFPCGQPNRPGVYT
----RVSQY------VLWIHETIKNHKTPERKWTKGTQ----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------MSLR---------------------------------------------
-----------ALGSG-TWPSAPKMF----LLLTALQVLAIDMTRSQE-DENKIIGGYTC
TRSSQPWQAALLAG--PGRRFLCGG-ALLSDQWV------ITAAHCGRP-----------
ILQV---------------ALGKHNLRRWEATQQVLRVVRQVTHPNY--------NSRTH
ENDLMLLRLQQPARIGRAVRPTEVAQACASPG-TSCRVSGWGTISSPIA-----------
-------RYPASLQ-CVNIN--------ISPDEV-------CQKAYSK-AITPGMVCAGV
PQ------GGKDSC---QG---------DSGGP---------LV-CRGQ-LQGLV--SWG
ME-RCALPGYPGVYTNLCKYRSWIEETMRHK-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------MGRLRP-RAAQTWMFLLLLGAAWAACGRLDLL--TKLYAENLP
CVHLNLQW-PSQPW---------HCP------RGWRSNPLPPAAGHSRAQEEKVLGGQEC
RPHSQPWQAALFQ----GKQLLCGG-VLIGGNWI------LTAAHCKKP-----------
KYTV---------------RLGDHSLHNKDGPEQEIPVVQSIPHPCYN-----SSDVDDH
NHDLMLLQLRDQASLGPKVKPINLADHCTQPG-QTCIISGWGTVTSPRE-----------
-------NFPDTLN-CAEVK--------IFPQ-------KKCEDAYPG-QITDGMVCAGS
S-------KGADTC---QG---------DSGGP---------LV-CNGA-LQGIT--SWG
SD-PCGRSDRPGVYTNICRYLDWIKKTIGSKG----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------FYLYLST--A-QDGDKVLEGEEC
VPHSQPWQVALFE----RGRFNCGA-FLISPHWV------LTAAHCQTR-----------
FMRV---------------RLGEHNLRKFDGPEQLRSVSRIIPHPGY--------EARTH
RHDIMLLRLFRPARLTPQVRPVALPTRCPLLG-EDCVVSGWGLLSDNSPGA-TG------
-SHKSQVRLPDTLH-CANIS--------IISE-------ASCNKDYPG-RVLPTMVCAGV
EG------GGTDSC---EG---------DSGGP---------LV-CGGA-LQGIV--SWG
DV-PCDTTTKPGVYTKVCSYMDWIRKNMRRN-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------MKLG--------L--------------LCA-LLSLLAG-HGWADTRAIGAEECR
PNSQ-PWQAGLFH-LTRLFCGATLISDRWLLTAAHCRK------P---------------
-----YLWVRLGEH-HLWKWEG--PEQLFRATDFFPHPGFNKDLSANDHNDDIMLIRLPR
QARLSPAVQPLNLS-QTCVSPGTQCLISGWGAVSSPKALFPVTLQCANISILENKLCH--
WAYPGH-ISDSMLCAGLWEGGRGSCQGDSGGPLVCNGTLAGVVSGGAEPCSRPRRPAVYT
----SVCHY------LDWIQEIMES-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------MKKLMVALVLMATAWAQEQNKVVQGEPC
E-NSHPYQAALYT----AGHLLCGG-VLIHREWV------LTAAHCRKQ-----------
NLQV---------------YLGKHNLRQRESFQEQSSVVQAVTHPGY--------DPATH
DQDIMLLHLARPARLSEHIQPLPLERDCSASH-TSCHILGWGKTA--DG-----------
-------IFPDTIQ-CARVH--------LVPR-------EKCELAYPG-QITQNMVCAGD
EK------HGKDSC---QG---------DSGGP---------LV-CGDR-LRGLV--SWG
NI-PCGSKEKPGVYTNVCRYFSWIRRTIQSKGS---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------MGRPPP-CATQTWILLFLLMGAWA-------------------
--------------------------------------------GLTRAQGSKVLEGQEC
APHSQPWQTALFQ----GPRLVCGG-VLVGDNWV------LTAAHCKKQ-----------
KYSV---------------RLGDHSLQSRDEPEQEIQVAQSIQHPCYN-----SSNPEDH
SHDVMLVRMRRSAKLGNKVKAINLTNECPRVG-QKCTISGWGTVTSPRE-----------
-------NFPDTLN-CAQVE--------IFSQ-------NKCERAYPG-KVNEGMVCAGS
S-------NGADTC---QG---------DSGGP---------LV-CNGM-LQGIT--SWG
SD-PCGKPDKPGVYTNICRYIDWITKTMNIRD----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---MRILQL-------------------------IM-LALAT-G-LVGGETRIIKGFECK
PHSQ-PWQAALFE-KTRLLCGATLIAPSWLLTAAHCRKPWVSLTSPNHVSPDLS-SSNYR
LSHLSRYIVHLGEH-NLQKQDG--CEQTRTATESFPHPGFNNSLPNKDHRNDIMLVKMAS
PAFITWAVRPLTLS-SRCVTAGTSCLISGWGSTSSPQLRLPHSLRCANITIIEHQKCE--
NAYPSN-ITDTMVCASVQEGGKDSCQGDSGGPLVCNHSLQGIISWGQDPCAITRKPGVYT
----KVCKY------VDWIQETMKNN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
FMKV---------------RLDEHNLRQHDGREQLRMVSRVIPHPRY--------KARSH
LHDLMLLRLVRPARLSAQVHPVALPARCPRAG-EACLVSGWGLVSNDKQSHKGG------
-SGSSQVILPDTLH-CANIS--------VISD-------ESCNKDYPG-RLTKTMVCAGV
EG------GGTDSC---E------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
MRRLKS---DWKLST---------------E--------------TREPGARPAL-----
LQARMILRL-------------------------IA-LALVT-G-HVGGETRIIKGYECR
PHSQ-PWQVALFQ-KTRLLCGATLIAPKWLLTAAHCRKP---------------------
-----HYVILLGEH-NLEKTDG--CEQRRMATESFPHPDFNNSLPNKDHRNDIMLVKMSS
PVFFTRAVQPLTLS-PHCVAAGTSCLISGWGTTSSPQLRLPHSLRCANVSIIEHKECE--
KAYPGN-ITDTMLCASVRKEGKDSCQGDSGGPLVCNGSLQGIISWGQDPCAVTRKPGVYT
----KVCKY------FNWIHEVMRNN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------MWLLLAFVLL-VS--AAQDGDKVLEGEEC
APHSQPWQVALFE----RGRFNCGA-FLISPHWV------LTAAHCQTR-----------
FMRV---------------RLGEHNLRKHDGPEQVRSVSRIIPHPGY--------EARTH
RHDIMLLRLLHPARLSSQVHPVALPTRCPFTG-EDCVVSGWGLLSANKPGD-SE------
-SHKSQVRLPDTLH-CANIS--------IISE-------ASCNKDYPG-RVLPTMVCAGV
EG------RGTDSC---EG---------DSGGP---------LV-CRGA-LQGIV--SWG
DV-PCDTTTKPGVYTKVCSYLKWIRENMKRN-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------M----RR
PRRLKS---DWRFST---------------V--------------PRDPGAHPAL-----
LRAMTILRF-------------------------IA-LALVT-G-HVGGETRIIKGYECT
PHSQ-PWQVALFQ-KTRLLCGATLITPKWLLTAAHCRKP---------------------
-----HYLVLLGEH-NLEKTDG--YEQKRTATESFPHPGFNNSLPNKDHRNDIMLVKMSS
PAVVTRAVRPLTLS-SHCVTAGTSCLISGWGTTSSPQLRLPHSLRCANVSIIEHKECE--
SAYPGN-ITETMLCASVRKEGKDSCQGDSGGPLVCDGSLQGIISWGQDPCAVTRKPGVYT
----KVCKY------IDWIHETMRNN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------MSLR---------------------------------------------
-----------VLGSG-TWPSAPKMF----LLLTALQVLAIDMTRSQE-DENKIIGGYTC
TRSSQPWQAALLAG--PGRRFLCGG-ALLSDQWV------ITAAHCGRP-----------
ILQV---------------ALGKHNLRRWEATQQVLRVVRQVTHPNY--------NSRTH
ENDLMLLRLQQPARIGRAVRPIEVAQACASSG-TSCRVSGWGTISSPIA-----------
-------RYPASLQ-CVNIN--------ISPDEV-------CQKAYSK-AITPGMVCAGV
PQ------GGKDSC---QG---------DSGGP---------LV-CRGQ-LQGLV--SWG
ME-RCALPGYPGVYTNLCKYRSWIEETMRHK-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------MGRPRP-RAAKTWMFLLLLGEAWC-VDAWTSL--TKLYAENLL
CVHLN--------------------P------QGWRSNPLPPAAGHSRAQENKVLGGQEC
RPHSQPWQAALFQ----GKQLLCGG-VLIGGNWI------LTAAHCKKP-----------
KYTV---------------RLGDHSLQKKDGPEQEIPVVQSIPHPCYN-----SSDVEDH
NHDLMLLQLRDQASLGPKVKPISLADHCTQPG-QMCIISGWGTVTSPRE-----------
-------NFPDTLN-CAEVK--------IFPQ-------KKCEDAYPG-QITDGMVCAGS
S-------KGADTC---QG---------DSGGP---------LV-CNGA-LQGIT--SWG
SD-PCGRSDRPGVYTNICRYLDWIKKTIGSKG----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----RILRL-------------------------IT-LALVT-G-QVGGETRIIKGFPCP
PHSQ-PWQVALFQ-KTRLLCGATLIAPQWLLTAAHCRKP---------------------
-----NYRVLLGEH-NLHREDG--YEQRQTATESFPHPGFNNSLPNKDHRNDIMLVKLPR
AADITQAVRPLSLP-SHCVTAGTNCLISGWGTTSSPQLRLPNTLRCANISIIRHGECE--
RAYPGN-ITDTMVCASVRKEGKDSCQGDSGGPLVCNGSLQGIISWGQDPCAVSRKPGVYT
----KVCKY------VDWIQKIMHNN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----MW---ALAAA-VACLTVALSRGISQDYPKIL------NG-TNGTHGFLPGGYTCV
PHSQ-PWQAALLV-QGRLLCGGVLVDPKWILTAAHCRKE---------------------
-----GYRVHLGKH-ALGRLE--SGEQVREVVHSIPHPEYQVSPTHLNHDHDIMLLELES
PVQLNSHVRTLPLSQDDCLPPGTCCRVSGWGTTTSPQVNYPKTLQCANIELRSDEECR--
QVYPGK-ITANMLCAGTKEGGKDSCEGDSGGPLVCNHKLYGIISWGDFPCGQPNRPGVYT
----RVSKY------LRWIRETIRNTSEQ--RWTKGTP----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------T----RK
LSWLGFGKS-SDLRH---------------R--------------AKEPGACPAP-----
LQAMMILQL-------------------------IM-FALVT-G-HVGGETRINKGYECS
PHSQPPWQAALFQ-KTQLLCGA-LIALKWLLTAAHCHRP---------------------
------YVAHLGEH-SLH-RDG--CEHTRGATESFPHPDFNSSLPNTAHCDDITLLNMVA
PAFVIWAVRPR-VS-SHCVTAGTRCLISDWGTTSCPQLHFPHT-RCTNMTIIEHKEYE--
DAYPGD-ITDTMGCTSVREEGKESCQGDSGGPLVYNGSLQGITSWGQDPCAVSRKPRVYT
----KVC-Y------VVRIQKTIENN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----MW---PLALV-ITSLT--------VESSKVP------N--TNGTSGFLPGGYTS-
----------LLV-QGWLLCGGVLD-HKWVLTAAHCLND---------------------
-----GLKVYLGKH-ALGHVE--AGEQVREVVHSIPHPAYRRSPTHLNHDHDIMLLGLHP
NPA--PF-------PQQLPNPGTTCRVSGWGTTTSPQVNYSKTLQCANIQLGSDEECH--
QVYPGK-ITDNMLCASTKEGGKDSREGDSGGLLVCNRTLYGIISWGDFPCGQPDQPGVCT
----RVSRY------ILWIRETVRKYETQQQKCLKGPQ----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------MWLLLIFSILVTS--AAQDRDKALEGEEC
VPHSQPWQVALFE----RGRFNCGA-SLISPRWV------LSAAHCLTR-----------
FMRV---------------RLGEHNLRKRDGPEQLRMVSRIIPHPQY--------EARSH
RHDVMLVRLARPARLTPQVRPVALPTRCPDPG-EACRVSGWGLVSNKESGT-TG------
-SPESQVSLPDTLH-CANIS--------IISD-------ASCNKDYPG-RLTSAMVCAGV
EG------GGTDSC---EG---------DSGGP---------LI-CRGA-LQGIV--SWG
DV-PCDTTTKPGVYTKVCRYLKWIRETMKRN-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------FPFSGMG------MKKLIVALILMAAAWAEEQNKVLHGGPC
EQTSHPYQAALYT----SGHLLCGG-VLIHPLWV------LTAAHCKKP-----------
NLQV---------------YLGKHNLQQRESFQEQSSVLRAVAHPGY--------NAATH
DQDIMLLRLAQPAQFSECIQPLSLAEDCSANH-TSCHILGWGKTA--DG-----------
-------GFPNTIQ-CAYIH--------LVSR-------EECERAYPS-QITQNMVCAGD
EK------YGKDSC---QG---------DSGGP---------LV-CGDR-LRGLV--SWG
NV-PCGSKEKPGVYTDVCRYGHWIRKTIQAN-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------M----QR
LRRLQDWKSSGRGLA---------------A--------------AKEPGARPSP-----
LQAMRILQL-------------------------IM-LALAT-G-LVGGETRIIKGFECK
PHSQ-PWQAALFE-KTRLLCGATLIAPSWLLTAAHCRKP---------------------
-----RYIVHLGEH-NLQKQDG--CEQTRTATESFPHPGFNNSLPNKDHRNDIMLVKMAS
PAFITWAVRPLTLS-SRCVTAGTSCLISGWGSTSSPQLRLPHSLRCANITIIEHQKCE--
NAYPSN-ITDTMVCASVQEGGKDSCQGDSGGPLVCNHSLQGIISWGQDPCAITRKPGVYT
----KVCKY------VDWIQETMKNN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------AWLPAHF---------------QTLSASAKWHFPIGGERIVPGGKPCI
PGSR-PYQVALVK-DGHIHCGGSLVEKKWVLTAAHCNKD---------------------
---LGSVRVHLGDY-NLRTNE--GTEQFRRVKNVIVHPEYNRR----PRDNDFMLLELDE
PAELNNDVKTISLA-TQCPAPGTKCIMSGWGSITSPQLTFPNELQCVELYSVSQDSCK--
ERYRGL-ITENMLCAGVEEGGRDSCEGDSGGPLVCDGILQGVVSWGTDVCALPKRPGVYA
----NVCKA------VQWVTDTIRDRP---------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------MEWLGVAL-LLVTAVSGFNPRIIGGAPC
EPHSKPWQAALFV----GSQLSCGG-TLIDKNWV------ITAAHCNI-----------S
ILTV---------------RLGEHNIRKLDFTEQLRLSAKMIIHPKY--------NSASK
DNDIMLIKLLTPANINRNVQPLALPTSCPTAG-QDCVVSGWGTTKSPEL-----------
-------RFPPVLY-CGNIS--------VFSQ-------EQCRSIYPR-YFTNNMFCAGL
PQ------GGVDSC---QG---------DSGGP---------LV-CNGV-LQGIV--SWG
TQ-TCALPNKPGVYVNICNYIDWIRETINNN-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------MF----LLLAALQVLAVATAQGPE-DDNKVIGGYTC
VQNSQPWQVALLAG--PGRRFLCGG-VLLSDQWV------ITAAHCARP-----------
ILHV---------------ALGKHNLKKWEATQQVLRVERQVPHPRY--------NARTH
DSDLILLRLSQRARIGRAVRPISLAQSCASPG-TSCRVSGWGTTSSPIA-----------
-------RYPNALQ-CVNIN--------IISSPQ-------CQRAYPN--ITAGMVCAGV
PQ------GGKDSC---QG---------DSGGP---------LV-CGGQ-LQGLV--SWG
ME-RCALPGYPGVYTNLCKYRSWIQRTEQGQ-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------VTVKMLT------VKTLVLCLVLAKSAWTEEKDKVVHGGPC
LKNSHPFQAALYT----SGHLLCGG-VLIHPQWV------LTAAHCKKT-----------
NLEV---------------RLGKHNLRQTENYQRQIFVDRTIIHPRY--------NPDTH
DNDIMMVHLKNAVKFSQNIQPLPLKKDCSEEN-LSCRILGWGKME--NG-----------
-------DFPDTIQ-CADVQ--------LVSR-------EECERAYPG-KITRSMVCAGD
KI------EGNDTC---QG---------DSGGP---------LV-CGDH-LRGLV--SWG
NM-PCGSKKKPGVYTDVCIHIRWIQNVIKNKWL---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------MKKLMVVLSLIAAAWAEEQNKLVHGGPC
DKTSHPYQAALYA----SGHLLCGG-VLIHPLWV------LTAAHCKKP-----------
NLQV---------------FLGKHNLRQRESSQEQSSVVRAVIHPGY--------DAATH
DQDIMLLRLARPAKLSELIQPLPLERDCSANT-TSCHILGWGKTA--DG-----------
-------DFPDTIQ-CAYIH--------LVPR-------EECERAYPG-QITQNMLCAGD
EK------YGKDSC---QV---------R-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------MGRLRP-RAAKTWMFLLLLGEAWAACGCLDLL--TKLYAENLP
CVHLNPQW-PSQPW---------HCP------RGWRSNPLPPAAGHSRAQEDKVLGGQEC
RPHSQPWQAALFQ----GKQLLCGG-VLIGGNWI------LTAAHCKKP-----------
KYTV---------------RLGDHSLHNKDGPEQEIPVVQSIPHPCYN-----SSDVDDH
NHDLMLLQLRDQASLGPKVKPINLADHCTQPG-QTCIISGWGTVTSPRE-----------
-------NFPDTLN-CAEVK--------IFPQ-------KKCEDAYPG-QITDGMVCAGS
S-------KGADTC---QG---------DSGGP---------LV-CNGA-LQGIT--SWG
SD-PCGRSDRPGVYTNICRYLDWIKKTIGSKG----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------MRLG--------F--------------LCA-LLSLLEG-QGWADTRAIGAKECR
PNSQ-PWQAGLFY-LTHLFCGATLISDRWLLTAAHCRK------W---------------
-----YLWVRLGEH-HLWKWEG--PEQLFRATDFFPHPGFNQDLTAQDHNNDIMLVRLPR
KAHLGPAVQPLNLS-QTCVSPGTQCLISGWGAVSSPKVEYPLTLQCANISILEPRLCR--
RAYPGH-ISDSMLCAGLWEGGRGSCQGDSGGPLVCNGTLAGVVSGGSEPCSRPRRPAVYT
----SVCHY------LDWIQETMEDN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------MWLLLAFVLLVSA--A-QDGDKVLEGEEC
VPHSQPWQVALFE----RGRFNCGA-FLISPRWV------LTAAHCQTR-----------
FMRV---------------RLGEHNLRKFDGPEQLRSVSRIIPHPGY--------EARTH
RHDIMLLRLFKPARLTAYVRPVALPRRCPLIG-EDCVVSGWGLLSDNNPGA-TG------
-SQKSHVRLPDTLH-CANIS--------IISE-------ASCNKDYPG-RVLPTMVCAGV
EG------GGTDSC---EG---------DSGGP---------LV-CGGA-LQGIV--SWG
DV-PCDTTTKPGVYTKVCSYLEWIWENVRRY-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------NLQVFLGKHNLHKSESSQEHISVVQTVSHPGY--------TAATH
DQDIMLLRLARPAHLSDLIKPLALERDCSSSE-TSCQILGWGKTA--DX-----------
-------XXXXXXX-XXXXX--------XXXX-------XXXXXXXXX-XXXXXXXXXGD
EK------YGRDSC---QG---------DSGGP---------LV-CGDR-LRGLI--SWG
NI-PCGSKEKPGVYTNICRYFNWIQNIIQGRR----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------MWLV-LTSFLL-MSAAQ-D-----NDEEC
VPHSQPWQVALFA----GGRFNCGA-SLISFQWV------LTAAHCRTR-----------
FMRV---------------RLGEHNLRKRDGPEQLRLVSRIIPHPGY--------EARSH
RHDIMLLQLARPARLTRQVRPVPLPTRCPHPG-EPCVVSGWGLVSDNKPET-TG------
-SSKSQVTLPDTLH-CANIS--------VISQ-------ASCSKDYPG-RLMDTMVCATV
EG------GGTDSC---EG---------DSGGP---------LV-CEGA-LQGIV--SWG
DV-PCDTTTKAGVYTKVCRYLQWIRETM--------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------MEVT--------KLLATFLLLQLSFALSFRTRIIGGEIC
AEDGHPWLAWIYG----SNGLQCSG-VLINQDWV------LTAAHCYER----------S
GMQL---------------KLGVHNREVPREGEQLRTSAEAKCYPDAASSDSNSCAQNTF
INDIMLVKLNAPVDYNDNVQPVPLSTAVPEEG-TICKVMGWGSINASED-----------
-------IYPLVPY-CVDIE--------ILNN-------GVCEAAYPWCTAYDKLLCAGV
LE------GGKDSC---HG---------DSGGP---------LM-CGDE-LQGIL--SFG
GH-PCAKPLEPGVYVKVDSYLDWIQSIIENNTPETS------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
ILRV---------------ALGKHNLKKREATQQVLRVARQVPHPQY--------NPRTH
DNDLMLLRLERPARLGSAVRPIPVARTCAGPQ-TPCRVSGWGTTSSPIA-----------
-------RYPNALQ-CVNIS--------ITSRQQ-------CQQAYSG-AITDGMVCAGT
PE------GGKDSC---QG---------DSGGP---------LV-CHGK-LQGLV--SWG
ME-RCALPGYPGVYTNLCKYYDWIQQTILGA-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----MW---PLVAT-IACLTLALSGGISRDYPKIL------NG-TNGTSGFLPGGYTCL
PHSQ-PWQAALLI-RGRLLCGGVLVHPKWVLTAAHCRKD---------------------
-----GYTVHLGKH-ALGHVE--KGEQAMEVVRSIPHPEYQVSPTHLNHDHDIMLLELKS
PVQLSSHIRTLQLSADDCLPTGTCCRVSGWGTTTSPQVNYPKTLQCANIELRSDEECR--
QVYPGK-ITANMLCAGTKEGGKDSCEGDSGGPLICNGKLYGIISWGDFPCGQPNRPGVYT
----RVSKY------LHWIQKIIRNTPEQ--RWTKGTQ----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----MW---PLALV-IASLTLALSGGVSQESSKVL------N--TNGTSGFLPGGYTCF
PHSQ-PWQAALLV-RGRLLCGGVLVHPKWVLTAAHCLKE---------------------
-----GLKVYLGKH-ALGRVE--AGEQVREVAI-LSPPEYKRSPTHLCS----------L
GVQLTGCIQTLPLSHNNRLTPGTTCRVSGWGTTTSPQVNYPKTLQCANIQLRSDEECH--
QVYPGK-ITDNMLCAGTKEGGKDSCEGDSGGPLVCNRTLYGIVSWGDFPCGQPDRPGVYT
----RVSRY------VLWIRETIRKYETQQQKWLEGPQ----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------MF----LLLTILQALAVALAQSQG--DHKIIGGYTC
VRNSQPWQVALQAG--PQRSLLCGG-VLLSNEWV------ITAAHCARP-----------
ILYV---------------ALGKHNIRRWEATQQVVRVVRQVPHPQY--------RPQAH
DNDLMLLKLQTKVRLGRAVKTISTASSCASPG-TPCRVSGWGTIASPIA-----------
-------RYPTALQ-CVNVN--------IMPEQA-------CHRAYPG-IITSGMVCAGV
PE------GGKDSC---QG---------DSGGP---------LV-CGGQ-LQGLV--SWG
ME-RCATPGYPGVYTNLCNYHGWIQRTMQSN-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------FAEEQEKLVHGGPC
DRHAHPYQAALYS----SDHLLCGG-VLIHEDWV------LTAAHCKKE-----------
KLYI---------------RLGEHNLRNSINTQ-RRSVVKAVAHPGF--------NPATH
DQDIMLLRMSKPANFSAWIKPLALERDCQARS-TSCHILGWGRTE--EG-----------
-------VFPDTIQ-CAYVQ--------LVPR-------DECEHAYPG-QITRNMVCAGD
PK------EGTDAC---QG---------DSGGP---------LV-CGGR-LRGLV--SWG
NV-PCGSKEKPGVYTDVCRYVSWIQRTIRGN-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------MGRPPP-CAIQPWILLLLFMGAWA-------------------
--------------------------------------------GLTRAQGSKILEGREC
IPHSQPWQAALFQ----GERLICGG-VLVGDRWV------LTAAHCKKQ-----------
KYSV---------------RLGDHSLQSRDQPEQEIQVAQSIQHPCYN-----NSNPEDH
SHDIMLIRLQNSANLGDKVKPVQLANLCPKVG-QKCIISGWGTVTSPQE-----------
-------NFPNTLN-CAEVK--------IYSQ-------NKCERAYPG-KITEGMVCAGS
S-------NGADTC---QG---------DSGGP---------LV-CDGM-LQGIT--SWG
SD-PCGKPEKPGVYTKICRYTTWIKKTMDNRD----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------MP-SQALVWTTLLLL----LG------------------
-----------------------------------------GQAGRSRAQGSKILEGQEC
KPHSQPWQAGLFQ----GQRLICGG-VLVGTNWV------LTAAHCKKM-----------
KYTV---------------RLGDHSLQSRNEGEQEMYVARSIQHPCYN-----NSNPEDH
SHDLMLIRLRKQADLGPTVKPIDLAYHCTHQG-QKCTISGWGTVTSPQE-----------
-------NFPDTLN-CANVE--------IFSQ-------KKCEEAYPG-KINDGMVCAGN
S-------NGADTC---QG---------DSGGP---------LV-CGGV-LQGIT--SWG
SD-PCGRPERPGVYTNLCRYHDWMKKTMGNRD----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------LSLG-------LL--------------APF-LGVSAPG-HGQADTRAIGAEECP
RHSQ-PWQAGLFH-LTRLFCGATLIRERWVLTAAHCRK------P---------------
-----FLWVRLGEH-HLWKWEG--SEQLFRATEFFPHPGFNSDLRANDHNNDIMLIHLPR
PARLGPAVQPLNVS-ETCVDPGNQCLISGWGAVSSPKGTYPLTLQCANISILNTMLCH--
WAYPGH-ISESMLCAGLWEGGRGSCQGDSGGPLVCNGTLAGVVSGGSEPCSRPRRPAVYT
----SVCHF------SDWIQKTIEENQ---------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------MKKLMVVLSLIAAAWAEEQNKLVHGGPC
DKTSHPYQAALYT----SGHLLCGG-VLIHPLWV------LTAAHCKKP-----------
NLQV---------------FLGKHNLRQRESSQEQSSVVRAVIHPDY--------DAASH
DQDIMLLRLARPAKLSELIQPLPLERDCSANT-TSCHILGWGKTA--DG-----------
-------DFPDTIQ-CAYIH--------LVSR-------EECEHAYPG-QITQNMLCAGD
EK------YGKDSC---QG---------DSGGP---------LV-CGDH-LRGLV--SWG
NI-PCGSKEKPGVYTNVCRYTNWIQKTIQAK-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----MW---PLAAA-VACLTLALSGGISQEYPKIL------NG-TNGTSGFLPGGYTCL
PHSQ-PWQAALLV-RRRLLCGGVLVHPKWVLTAAHCMKA---------------------
-----GYTVHLGKH-VLGRVE--TREQVREVARSVPHPEYQVSPTHLNHDNDIMLLELAS
PVQLTGHIRTLPLSRSDCLPPGTCCRVSGWGTTTSPQVSYPKTLQCANIPLRSDEECR--
RVYPGK-ITANMLCAGSKEGGKDSCEGDSGGPLVCNGTLHGIISWGDFPCGQPNRPGVYT
----RVSKY------VSWIHETIKKHKTQEQKWTKGAQ----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------AQDNDKVLGGEEC
APHSQPWQVALFE----HGRFNCGA-SLIAPYWV------LSAAHCQTR-----------
FMRA---------------RLGEHNLRKRDGPEQFLTISRVIPHPNY--------EARDH
HHDVMLVRLHQPARISRQVRPIALPTRCPNPG-EACLVSGWGLVSDNKPAS-TG------
-HPKPQVNLPDTLH-CANIS--------IIST-------ASCNKEYPG-RLTDTMVCAGV
EG------GGTDSC---EG---------DSGGP---------LV-CGGV-LQGIV--SWG
DV-PCDTTTKPGVYTKVCHYMEWIRETMKRN-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------MG------MKTLIVAVILMAAAWAEEQNKVLHGGPC
EQTSHPYQAALYT----SGHLLCGG-VLIHPLWV------LTAAHCKKP----------W
QEVIHTTPCPSTRPSDNQVHLGSTMITSSNSLL--WGEERGLITQGY--------GLNKY
PQDG----LPHPQGDLALLPPF-------------SQLRSAGTVE--AG-----------
-------DFPNTIQ-CAYIH--------LVPR-------EECERAYPS-QITQNMVCAGD
EK------YGKDSC---QG---------DSGGP---------LV-CGDR-LRGLV--SWG
NV-PCGSKEKPGVYTDVCRYGHWIRKTIQAN-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------MKKLMVVLSLIAAAWAEEQNKLVHGGPC
DKTSHPYQAALYT----SGHLLCGG-VLIHPLWV------LTAAHCKKP-----------
NLQV---------------FLGKHNLRQRESSQEQSSVVRAVIHPGY--------DAATH
DQDIMLLRLARPAKLSELIQPLPLERDCSANT-TSCHILGWGKTA--DG-----------
-------DFPDTIQ-CAYIH--------LVPR-------EECERAYPG-QITQNMLCAGD
EK------YGKDSC---QG---------DSGGP---------LV-CGDH-LRGLV--SWG
NI-PCGSKEKPGVYTNVCRYRNWIQKTIQAK-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------MKLG--------L--------------LCA-LLSLLAG-HGWADTRAIGAEECR
PNSQ-PWQAGLFH-LTRLFCGATLISDRWLLTAAHCRK------P---------------
-----YLWVRLGEH-HLWKWEG--PEQLFRVTDFFPHPGFNKDLSANDHNDDIMLIRLPR
QARLSPAVQPLNLS-QTCVSPGMQCLISGWGAVSSPKALFPVTLQCANISILENKLCH--
WAYPGH-ISDSMLCAGLWEGGRGSCQGDSGGPLVCNGTLAGVVSGGAEPCSRPRRPAVYT
----SVCHY------LDWIQETMEN-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----MW---PLALV-IACLTLALSGGVSQESSKVL------N--TNGTSGFLPGGYTCF
PHSQ-PWQAALLV-QGRLLCGGVLVHPKWVLTAAHCLKD---------------------
-----GLKVYLGKH-ALGRVE--AGEQVREVVHSIPHPEYRRSPTHLNHDHDIMLLELQS
PVQLTGYIQTLPLSHNNRLTPGTTCRVSGWGTTTSPQVNYPKTLQCANIQLRSDEECH--
QVYPGK-ITDNMLCAGTKEGGKDSCEGDSGGPLVCNRTLCGIVSWGDFPCGQPDRPGVYT
----RVSRY------VLWIRETIRKYETQQQKWLKGPQ----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------MSLR---------------------------------------------
-----------VLGSG-TWPSAPKMF----LLLTALQVLSIAMTRSQE-DENKIIGGYTC
TRSSQPWQAALLAG--PRHRFLCGD-TLLSDQWV------ITAAHCGRP-----------
ILQV---------------ALGKHNLRRWEATQQVLRVVRQVTHPNY--------KSRTH
DNDLMLLRLKQPARIGRAVRPIEVTQ----------------------A-----------
-------RYPASLQ-CVNIN--------ISPDEV-------CQKAYPR-AITPGMVCAGV
AQ------GGKDSC---QG---------DSGGP---------LV-CRGQ-LQGLV--SWG
ME-RCALPGYPGVYTNLCKYRSWIEETMRDK-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------MWLLLVSIVL-VS--AAQDGDKMLEGEEC
VPHSQPWQVALFE----RGRFNCGA-SLISPYWV------LSAAHCQTR-----------
FMRV---------------RLGEHNLRRRDGPEQLRAVSRIIPHPNY--------EARSH
RHDVMLIRLLQPARLSPQVHPVALPTRCPRPG-ESCVVSGWGLVSDKEPGA-TG------
-SPESQVSVPDTLH-CANIS--------IISE-------ASCNKEYPG-RVLRTMVCAGI
EG------GGTDSC---EG---------DSGGP---------LV-CSGA-LQGIV--SWG
DV-PCDTTTKPGVYTKVCSYLEWIRETMKRN-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------MGRPRP-RAAKTWMFLLLLGEAWR-VDAWTSL--TKLYAENLL
CVHLN--------------------P------QGWRSNPLPPAAGHSRAQEDKVLGGQEC
RPHSQPWQAALFQ----GKQLLCGG-VLIGGNWI------LTAAHCKKP-----------
KYTV---------------RLGDHSLQKKDGPEQEIPVVQSIPHPCYN-----SSDVEDH
NHDLMLLQLRDQASLGPKVKPISLADHCTQPG-QTCIISGWGTVTSPRE-----------
-------NFPDTLN-CAEVK--------IFPQ-------KKCEDAYPG-QITDGMVCAGS
S-------KGADTC---QG---------DSGGP---------LV-CNGA-LQGIT--SWG
SD-PCGRSDRPGVYTNICRYLDWIKKTIGSKG----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------MQL--------------A--------AKLRTRASYRGPARPAP
HPGAAMW---PLAAV-IAFLMVALSGGISQEYPKIL------NG-SNGTSGFLPGGYTCR
PHSQ-PWQAALLV-QGRLFCGGVLVHPKWVLTAAHCLKE---------------------
-----GYRVYLGKH-ALGRVE--AGEQVREVVRSIPHPQYQISPTHLNHDHDIMLLELQS
PVQLTSHIRVLPLSHNDCLPAGTCCRVSGWGTTTSPQVTYPQTLQCANIQLRSDEECC--
QVYPGK-ITPNMLCAGSKEGGKDSCEGDSGGPLICNGTLHGIISWGDFPCGQPNRPGVYT
----RVSQY------VLWIRDTIRKHRTQEQKWTKSPQ----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------MGRPLP-CAGLMWAVL----LLLLA------------------
--SWA---------------------------------------GRTEAQESKVLQGHEC
EAHSQPWQTALFQ----GQRLLCGG-VLVDPMWV------LSAAHCKKI-----------
KYTV---------------RLGDHSLLS--KPDQEISVARSIQHPCFN-----HSNNEDH
SHDLMLIRLSKQAALGPKVKPINLAKQCARVG-QKCTISGWGTVTSPRE-----------
-------NFPDTLN-CAEVE--------IFSQ-------KKCEEAYPG-KVNDGMICAGN
S-------NGADTC---QG---------DSGGP---------LV-CGGV-LQGIT--SWG
SD-PCGRPKKPGVYTNICRYLNWIKKTMGNRS----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------MWLLLCFSILLTSAGAQ-DGDTGLQDEEC
APHSQPWQVALFE----GGRFNCGA-SLISPQWV------LSAAHCQSR-----------
FMRV---------------RLGEHNLHKREGSEQLRAVSRVIPHPNH--------EARTH
NHDVMLLKLARPVRLTREVCPLALPGRCPRPG-EACVVSGWGLVLEDESKS-RG------
-SLKSQVSLPDSLH-CANIS--------IVST-------ESCNKEYPG-RLRNTMVCAGV
EG------RGTDSC---E------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------ML----LLLTVLQALALAMVQSQG--DHKIIGGYTC
IQNSQPWQVALQTG--PGRRLVCGG-VLLSDRWV------ITAAHCARP-----------
ILHA---------------ALGKHNLRRWEATQQMVRVIRQVPHPQY--------QPRAH
NNDLMLLQLQKRVRLGRAVRTIDVARSCASPG-TPCRVSGWGTTASPVA-----------
-------RYPNALQ-CVNVN--------IMSEEV-------CRRAYSA-TITSGMVCAGV
PE------GGKDSC---QG---------DSGGP---------LV-CGGQ-LQGIV--SWG
ME-RCAMPGYPGVYTNLCNYQNWIQRTMQGN-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------Y----LA
HPDSASQQ-DTGLGP---------------T--------------PPTPSLFSPP-----
--PLLPEPL-------------------------FC-PHSPP-G-HVGGETRIIKGYECS
PHSQ-PWQVALFQ-KTRLLCGATLIAPKWLLTAAHCRKP---------------------
-----RYLVHLGEH-NLQRRDG--CEQTRTATESFPHPDFNNSLPNKDHRNDIMLVKMTT
AAFITRAVRPLTLS-SRCVAPGTRCLISGWGTTSSPQLHLPHTLRCANITIIKHEECE--
NAYPGN-ITDTMVCASVREEGKDSCQGDSGGPLVCDGSLQGIISWGQDPCAVTRKPGVYT
----KVCKY------VDWIQKTMEDN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----MKLGF--------GF--------------TWV-LLSLLAG-HSWADTRAIGAKECP
RNSQ-PWQAGLFF-LTRLFCGATLISDRWLLTAAHCRK------P---------------
-----YLWVRLGEH-HLWQWEG--PEQLFRVTDFFPHPGFNSDLSANDHNHDIMLIRLPR
RVSLGPVVQPLNIS-RTCVSPGTKCLISGWGAVSSPKVRFPLTLQCANISILEPIFCH--
LAYPGH-ISDNMICAGRWEGGLGSCQGDSGGPLVCDGALAGVVSGGGEPCSRPRRPTVYT
----RICHY------HDWIRKTMKENSP--------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----MW---PLALV-IASLTVALSGGISQESSKVL------N--TNGTSGFLPGGYTCF
PHSQ-PWQAALLV-RGRLLCGGVLVHPKWVLTAAHCLKE---------------------
-----GLKVYLGKH-ALGRVE--A------------------------------------
-------------------------------------VNYPKTLQCANIQLRSDEECR--
QVYPGK-ITDNMLCAGTKEGGKDSCEGDSGGPLVCNRTLYGIISWGDFPCGQPDRPGVYT
----RVSRY------VLWIRETIRKYETQQQKWLKGPQ----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------MF----FLLTALQVMAIAMAQSPE-DDNKIIGGYTC
VQNSQPWQAALWVG--P-RRFLCGG-ALLSSQWV------ITAAHCARP-----------
YLEV---------------ALGKHHLRRWEATQQVLRVARQVPHPEY--------NARTH
NNDLMLLRLAKPARLGRAVRPIPLATSCASPG-TACHVSGWGTTSSPIV-----------
-------RYPQTLQ-CVNIK--------ISSDQA-------CQQAYSG-AITPGMICAGV
PQ------GGKDSC---Q------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
---------------------------------------ME---------RLVPRGK--G
CKP-ASR-SPEVGV----GA---GVCTPPL-----PLY--------LHPPPAHPSKDGTW
GGDADSRVKVFPSKGESRL-----------------------------GNAERGVEAGRG
GPWMEFSARP----HDLL------------------------------QCHRLRPPAPSP
DHKVTMW---PLAAL-IGFLTVAFSGGISREYPKIL------NG-TNGTSGFLPGGYTCL
PHSQ-PWQAALLV-KGRLLCGGVLIHPRWVLTAAHCLKN---------------------
-----KYSVYLGKH-TLGRVE--AGEQVKEVARSIPHPQYQISPSHLNHDHDIMLLELES
PVQLSRHIGVLPLSHHDCLHPGTCCRVSGWGTTTSPQGMHPRSWRGTLGRVGRKTSLFFF
FFFFGF-L----------------------------------------------------
-------RP------HLWHIEVLRLG---VQWDLKSPAH----TT----ATAV-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----MW---PLALV-IASLTLALSGGVSQESSKVL------N--TNGTSGFLPGGYTCF
PHSQ-PWQAALLV-QGRLLCGGVLVHPKWVLTAAHCLKE---------------------
-----GLKVYLGKH-ALGRVE--AGEQVREVVHSIPHPEYRRSPTHLNHDHDIMLLELQS
PVQLTGYIQTLPLSHNNRLTPGTTCRVSGWGTTTSPQVNYPKTLQCANIQLRSDEECR--
QVYPGK-ITDNMLCAGTKEGGKDSCEGDSGGPLVCNRTLYGIVSWGDFPCGQPDRPGVYT
----RVSRY------VLWIRETIRKYETQQQKWLKGPQ----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------MTF----VHLLPTHLFPLAIAQSQG--DHKIIGGYTC
IQNSQPWQVALLAG--PGRRFVCGG-VLLSDKWV------ITAAHCARP-----------
ILHA---------------ALGKHNLRRWEATQQVVRVGRQVPHPQY--------QPRAH
NNDLMLLQLQKRVRLGRAVRTIGVARLCASPG-TPCRVSGWGTTASPVA-----------
-------RYPNALQ-CVNVN--------IMSEEA-------CRRAYSG-AITSGMVCAGV
LE------GGKDSC---QG---------DSGGP---------LV-CGGQ-LQGLV--SWG
ME-RCAMPGYPGVYANLCNYQNWIQRTMQGN-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----RLLRL-------------------------IT-LALVT-G-HVGGETRIIKGQPCP
PHSQ-PWQVALFQ-KTRLLCGATLIAPRWLLTAAHCRKP---------------------
-----HYRVLLGEH-NLHREDG--CEQKQTAKESFPHPSFNNSHPNKDHRNDIMLVKLPK
AAVITRAVRPLALP-SRCVAAGTSCRISGWGTTSSPQLRLPHVLRCANISVIKHEECE--
HAYPGN-ITDTMVCASVQ-TGKDSCQGDSGGPLVCNGSLQGIISWGQDPCAVSRKPGVYT
----KVCKY------VDWIRKVMQDN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------RTEAQESKVLQGHEC
EAHSQPWQTALFQ----GQRLLCGG-VLVDPMWV------LSAAHCKKI-----------
KYTV---------------RLGDHSLLS--KPDQEISVARSIQHPCFN-----HSNNEDH
SHDLMLIRLSKQAALGPKVKPINLAKQCARVG-QKCTISGWGTVTSPRE-----------
-------NFPDTLN-CAEVE--------IFSQ-------KKCEEAYPG-KVNDGMICAGN
S-------NGADTC---QG---------DSGGP---------LV-CGGV-LQGIT--SWG
SD-PCGRPKKPGVYTNICRYLNWIKKTMGNRS----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----MW---PLALV-IASLTVALSGGISQESSKVL------N--TNGTSGFLPGGYTCF
PHSQ-PWQAALLV-RGRLLCGGVLVHPKWVLTAAHCLKE---------------------
-----GLKVYLGKH-ALGRVE--AGEQVREVVYSIPHPEYRRSPTHLNHDHDIMLLELQS
PVQLTGYIQTLSLSHNNRLTPGTTCRVSGWGTTTSPQVNYPKTLQCANIQLRSDEECR--
QVYPGK-ITDNMLCAGTKEGGKDSCEGDSGGPLVCNRTLYGIISWGDFPCGQPDRPGVYT
----RVSRY------VLWIRETIRKYETQQQKWLKGPQ----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------MKKLLVVLSLMAAAWAEEQNKLVHGGPC
EKTRHPYQAALYT----SGHLLCGG-VLIHPLWV------LTAAHCKKP-----------
NLQV---------------FLGKHNLRQRESSQEQSSVVQAVIHPGY--------DASTH
DQDIMLLRLAHPAKLSELIQPLPLERDCSANY-TSCHILGWGKTA--DG-----------
-------DFPDTIQ-CAYIH--------LVSR-------EECEHAYPG-QITQNMLCAGD
EK------YGKDSC---QG---------DSGGP---------LV-CGDR-LRGLV--SWG
NI-PCGSKEKPGVYTNVCRYTNWIQKTIQAK-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---MMILQL-------------------------IM-LALVT-G-HVGGETRIIKGYQCS
PHSQ-PWQVALFQ-KTRLLCGATLIAPKWLLTAAHCRKP---------------------
-----RYVVHLGEH-NLQRRDG--CEQTRTATESFPHPDFNNSLPNKDHRNDIMLVKMAT
AAFITRAVRPLTLS-SRCVTAGTRCLISGWGTTSSPQLHLPHTLRCANITIIKHEECE--
KAYPGN-ITDTMVCASVREEGKDSCQGDSGGPLVCDGSLQGIISWGQDPCAVTRKPGVYT
----KVCKY------VDWIQKTMDNN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------MKLG-------LT--------------L-V-LFSLLAG-HCGADTRAVGARECV
RNSQ-PWQAGLFY-LTRQLCGATLINDQWLLTAAHCRK------P---------------
-----YLWVRLGEH-HLWRWEG--PEQLLLVTDFFPHPGFNPDLSANDHNDDIMLIRLPR
KVRLTPAVQPLNLT-ESRPPVGTQCLISGWGSVSSSKLQYPMTLQCANISILDNKLCR--
WAYPGH-ISEKMLCAGLWEGGRGSCQGDSGGPLVCEGTLAGIVSGGSEPCSRPRRPAVYT
----NVFDY------LEWIESTMEKN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
MRRLKS---DWKLST---------------E--------------TREPGARPAL-----
LQARMILRL-------------------------VA-LALVT-G-HVGGETRIIKGYECR
PHSQ-PWQVALFQ-KTRLLCGATLIAPKWLLTAAHCRKP---------------------
-----HYVILLGEH-NLEKTDG--CEQRRMATESFPHPDFNNSLPNKDHRNDIMLVKMSS
PVFLTRAVQPLTLS-PHCVAAGTSCLISGWGTTSSPQLRLPHSLRCANVSIIEHKECE--
KAYPGN-ITDTMLCASVRKEGKDSCQGDSGGPLVCNGSLQGIISWGQDPCAVTRKPGVYT
----KVCKY------FNWIHEVMRNN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------M-SAAAQ-D-----SDEEC
APHSQPWQVALFG----RGRFNCGA-SLISPRWV------LTAAHCQTR-----------
FMTV---------------RLGEHNLRKRDGPEQLRLVSRIIPHPGY--------KARSH
RHDVMLLQLARPARLTRQVRPVPLPTRCPQPG-EPCVVSGWGLVSDNKPET-TG------
-SSESQVTLPDTLH-CANIS--------VISQ-------ASCNKDYPG-YLMDTMVCATV
EG------RGTDSC---EG---------DSGGP---------MV-CGGA-LQGIV--SWG
DV-PCDTTTKAGVYTKVCRYLQWIRETMKRN-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----MW---PLALV-ITSLT--------MESSKVL------N--TNGTSGFLPGGYTS-
----------LLV-QGWLLCGGVLVHPKWVLTAAHCLND---------------------
-----GLKVDLGKH-ALGRVE--AGE----------------SPTHLNHDHDIMLLELQS
LVQLTGYIQTLPLSHNNCLTPGTTCRVSGWGTTTSPQVNYSKTLQCANIQLGSDEECH--
QVYPGK-ITDNMLCASTKEGGKDSREGDSGGPLVCNRTLDGIISWGDFPCGQPDQPGVCT
----RVSRY------VLWIRETQQKCLKDPQ-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------ISREFPKIL------NG-TNGTNGPLPGGYTCL
PYSQ-PWQAALLV-RGRLLCGGVLVHPKWVLTAAHCRKD---------------------
-----GYRVYLGKH-ALGRVE--TGEQVREVVRSIPHPEYQVSATHLNHDHDIMLLELET
PVXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXSYPKTLQCANIQLRSDEECH--
QVYPGK-ITPNMLCAGTQEGGKDSCEGDSGGPLVCNGTLHGIISWGDFPCGQPNRPGVYT
----RVPQY------VQWIRDTIRRHKAQAQEWTKDTQ----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------VTMKTTTMT------VKMLALCLVLAKSAWTEEQDKVVHGVPC
MKNSHPFQAALYT----SGHLLCGG-VLIDPQWV------LTAAHCKKP-----------
NLEV---------------HLGKHNLRQTESFQRRISVDRTIVHPRY--------NPDTH
DNDIMMLHLRNPVKFSRKIMPLPLKKDCSKEN-PSCQILGWGKTE--NG-----------
-------DFPDTLQ-CADVQ--------LVSR-------DECERAYPG-KITRNMVCAGN
KK------EGNDSC---QG---------DSGGP---------LV-CGDR-LRGLV--SWG
DL-PCGSKKKPGVYTDVCSYTRWIQNIIKNKWL---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------MGRPLP-RASLMWAVL----LLLLA------------------
--SWA---------------------------------------GRTEAQGSKVLQGHEC
EAHSQPWQTALFQ----GERLLCGG-VLVGPRWV------LSAAHCKKR-----------
RYTV---------------RLGDHSLQSKDKPEQDISVAQSIQHPCYN-----NSNKDDH
DHDLMLIRLSKQASLGSKVKPIDLAKQCAKVG-QKCTISGWGTVTSPRE-----------
-------NFPDTLN-CAEVE--------IISQ-------KKCEEAYPG-QVTDGMICAGN
S-------DGADSC---QG---------DSGGP---------LV-CNGV-LQGIT--SWG
SD-PCGRPKKPGVYTNICRYLNWIKKTMGNKG----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-ISLPPSA-FLQ-------------G------SLVTTSFSLATSGSFMAEDSRVLGAEPC
NPHSQPWQAGLFQ----GVKLLCGG-VLVAPQWI------LTAAHCQKP-----------
RYTV---------------RLGDHSLQNPEGSEQEVKVVRSIPHPCHN-----SSK--SN
NHDLMLLKLQKPIKVNDNVKPIGLPSHCPQPD-QKCTVSGWGTTTSPRE-----------
-------TFPDILH-CADVY--------IWSQ-------RRCEKAYPE-KISDGMVCAGS
N-------TGADTC---QG---------DSGGP---------LV-CEGV-LQGIT--SWG
AD-PCGRQDKPGVYSSVCRYTQWIKKFINAN-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------MPIMKMLT------MKMLTLCLVLAKSAWSEEQEKVVHGGPC
LKDSHPFQAALYT----SGHLLCGG-VLIGPQWV------LTAAHCKKP-----------
NLEV---------------SLGKHNLRQTETFQRQISVDRTITHPLY--------NPTTH
DNDIMMVHLKNPVKFSKKIQPMPLKKDCFEEN-PHCQILGWGKME--NG-----------
-------DFPDTIQ-CADVQ--------LVSR-------EECERAYPG-KITRSMVCAGD
SK------EGNDSC---QG---------DSGGP---------LV-CGGH-LRGLV--SWG
DM-PCGSKKKPGVYTDICTHVRWIQNNLRSKWL---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------MGRPPP-CAIQPWILLLLLMGAWA-------------------
--------------------------------------------GLTRAQGSKILEGREC
KPHSQPWQAALFQ----GERLICGG-VLVGNRWV------LTAAHCKKE-----------
KYSV---------------RLGDHSLQSRDQPEQEIQVAQSIRHPCYN-----SSNPEDH
SHDIMLVRLRNSANLGDKVKPVELANLCPKVG-QKCIISGWGTVTSPQE-----------
-------NFPNTLN-CAEVK--------IYSQ-------NRCERAYPG-KVTEGMVCAGS
S-------NGADTC---QG---------DSGGP---------LV-CDGM-LQGIT--SWG
SD-PCGKPEKPGVYTKICRYSTWIKKTMNNRD----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------M----QR
LRWLQDGKSSGRGLA---------------A--------------AKEPGACPSP-----
LQAMRILQL-------------------------IM-LALVT-G-LVAGETRIIKGFECK
PHSQ-PWQAALFE-KTRLLCGATLIAPRWLLTAAHCRKP---------------------
-----RYIVHLGEH-NLQRRDG--CEQTRTATESFPHPGFNNSLPNKDHRNDIMLVKMAS
PAFITWAVRPLTLS-SRCVTAGTSCLISGWGSTSSPQLRLPHSLRCANITIIEHRECE--
HAYPNN-ITDTMVCASVQEGGKDSCQGDSGGPLVCNHSLQGIISWGQDPCAITRKPGVYT
----KVCKY------VDWIHETMSNN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------MGRPRP-RAAKTWMFLLLLGGAWA-------------------
--------------------------------------------GHSRAQEDKVLGGHEC
QPHSQPWQAALFQ----GQQLLCGG-VLVGGNWV------LTAAHCKKP-----------
KYTV---------------RLGDHSLQNKDGPEQEIPVVQSIPHPCYN-----SSDVEDH
NHDLMLLQLRDQASLGSKVKPISLADHCTQPG-QKCTVSGWGTVTSPRE-----------
-------NFPDTLN-CAEVK--------IFPQ-------KKCEDAYPG-QITDGMVCAGS
S-------KGADTC---QG---------DSGGP---------LV-CDGA-LQGIT--SWG
SD-PCGRSDKPGVYTNICRYLDWIKKIIGSKG----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------PLVFT------MRTLSLWLLLLASAWAEEQDKVVHGSPY
HLDAHPFQAALFT----SGHLFCGG-VLVDRQWV------LTAAHCKKP-----------
QLQV---------------YLGKHNLHHRESSEEE----FTVVHPNY--------HPQTR
DNDLMLLHLARPVKTSHRIQPLPKEPNCSAHK-SHCQTLGWDKTE-ETG-----------
-------VFPDTIN-CAEVH--------LVPK-------TDCEGAYPG-HFTRTMVCASS
DQ------EGADSC---QG---------DSEGP---------LI-CDNH-LRGIM--AWG
DS-PSGSKNKLGVYTDICMHLQWVKNVIR-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------MW-LLPLSFLLTSTAAQ-DGGKLLEGEEC
VPHSQPWQVALYE----RGRFNCGA-SLISPHWV------LSAAHCQSR-----------
FMRV---------------RLGEHNLRKRDGPEQLRTASRVIPHPRY--------EKRSH
RHDIMLLRLVQPARLTPQVRPVVLPMRCPHPG-EACVVSGWGLVSHNEPGT-TG------
-RPQSQVSLPDTLH-CANIS--------IISD-------ASCDKNYPG-RLTNTMVCAGA
EG------RGAKSC---EG---------DSGGP---------LV-CGGV-LQGIV--SWG
DV-PCDNTTKPGVYTKVCRYVKWIRETMKRN-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------M----QR
LRWLQDWKSSGRGLT---------------A--------------AKEPGARSSP-----
LQAMRILQL-------------------------IL-LALAT-G-LVGGETRIIKGFECK
PHSQ-PWQAALFE-KTRLLCGATLIAPGWLLTAAHCRKP---------------------
-----RYIVHLGQH-NLQKEEG--CEQTRTATESFPHPGFNDSLPNKDHRNDIMLVKMAS
PVSITWAVRPLTLS-SRCVTAGTSCLISGWGSTSSPQLRLPHTLRCANITIIEHQKCE--
NAYPGN-ITDTMVCASVREGGKDSCQGDSGGPLVCNESLQGIISWGQDPCAITRKPGVYT
----KVCKY------VDWIQETMKNN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------MF----LLLIILQALAVAIAQSQG--DHKIIGGYRC
VRNSQPWQVALQAG--PGHRFLCGG-VLLSDQWV------ITAAHCARP-----------
ILHV---------------ALGKHNIRRWEATQQVVRVARQVPHPQY--------QPQAH
DNDLMLLKLQKKVRLGRAVKTISVASSCASPG-TPCRVSGWGTIASPIA-----------
-------RYPTALQ-CVNVN--------IMSEQA-------CHRAYPG-IITSGMVCAGV
PE------GGKDSC---QG---------DSGGP---------LV-CGGQ-LQGLV--SWG
ME-RCAMPGYPGVYANLCNYHSWIQRTMQSN-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------ML--LLLTALQIMALAMAQSQE-DKDKILGGYTC
IQNSQPWQAALLAG--PFRSFLCGG-VLLSGQWV------ITAAHCARP-----------
ILHV---------------ALGKHNLKNWEATQQVLRVVRQVRHPQY--------NSRTH
NNDLMLLRLERPVRLGRAVKPIAVANTCMSPG-TPCLVSGWGTTSSPIA-----------
-------RYPNSLQ-CVNIN--------IFSDQE-------CQGAYPG-AITAGMVCAGV
PQ------GGKDSC---QG---------DSGGP---------LV-CKGQ-LQGLV--SWG
ME-RCALPGYPGVYTNLCKYQTWIQKTIRRR-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------MWLLLTLSSF---------LDKVREGEEC
VSHTQPWQVVLYE----HSRFNCGA-PLISPHWV------LTAAHCRTR-------Y---
AVRA---------------RLGEHNLRKRDGPEQLRAVSRSIPHPHY--------EARSH
RHDVMPLRLARPARLTPQVRPVALPTHCPLPG-EPCVVSGWGLVSDNKPGATGMYGYGYP
YPLSSPVTVPDTLH-CANIR--------IICQ-------ASCSKGYPG-HLMDTMVCTRQ
------------RV---EG---------DSGGP---------LI-CGGA-LWGIV--SWG
DA-PCDTTTKAGIHTKVCRYLQWIRDTMKRN-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---MMTLQL-------------------------IM-FALVT-G-HVGGETRIIKGYECP
PHSQ-PWQAALFQ-KTRLLCGATLIAPRWLLTAAHCRKPWVRGPGRGREGRRLEMERRRR
VSHFSRYVVHLGAH-SLGRQDG--CEQTRTATKSFPHPDFNNSLPNKDHRNDIMLVKMVT
PAHLTWAVRPLTVS-PRCVPAGANCLISGWGTMSSPQLHLPHTLRCANVTIIKHRECE--
DAYPGN-ITDTMVCASVRKEGKDSCQGDSGGPLVCNGSLQGIISWGQDPCAVSKKPGVYT
----KVCKY------VDWIQKTMENN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------M----QR
LRRLQDWKSSGRGLA---------------A--------------AKEPGARPSP-----
LQAMRILQL-------------------------IM-LALAT-G-LVGGETRIIKGFECK
PHSQ-PWQAALFE-KTRLLCGATLIAPSWLLTAAHCRKP---------------------
-----RYIVHLGEH-NLQKQDG--CEQTRTATESFPHPGFNNSLPNKDHRNDIMLVKMAS
PAFITWAVRPLTLS-SRCVTAGTSCLISGWGSTSSPQLRLPHSLRCANITIIEHQKCE--
NAYPSN-ITDTMVCASVQEGGKDSCQGDSGGPLVCNHSLQGIISWGQDPCAITRKPGVYT
----KVCKY------VDWIQETMKNN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------MKLG--------L--------------LCA-LLSLLAG-HGWADTRAIGAEECR
PNSQ-PWQAGLFH-LTRLFCGATLISDRWLLTAAHCRK------P---------------
-----YLWVRLGEH-HLWKWEG--PEQLFRVTDFFPHPGFNKDLSANDHNDDIMLIHLPR
QAHLSPAVQPLNLS-QTCVSPGTQCLISGWGAVSSPKALFPVTLQCANISILENKLCH--
WAYPGH-ISDSMLCAGLWEGGRGSCQGDSGGPLVCNGTLAGVVSGGAEPCSRPRRPAVYT
----SVCHY------LDWIQEIMEN-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------MGRPRP-RAAKTWMFLLLLGEAWL-VDAWTSL--TKLYAENLL
CVHLN--------------------P------QGWRSNPLPPAAGHSRAQEDKVLGGQEC
RPHSQPWQAALFQ----GKQLLCGG-VLIGGNWI------LTAAHCKKP-----------
KYTV---------------RLGDHSLQKKDGPEQEIPVVQSIPHPCYN-----SSDVEDH
NHDLMLLQLRDQASLGPKVKPISLADHCTQPG-QTCIISGWGTVTSPRE-----------
-------NFPDTLN-CAEVK--------IFPQ-------KKCEDAYPG-QITDGMVCAGS
S-------KGADTC---QG---------DSGGP---------LV-CNGA-LQGIT--SWG
SD-PCGRSDRPGVYTNICRYLDWIKKTIGSKG----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----SF---PCEPQ-FS-NTFSPLPGISREYPKIL------NG-TNGTNGFLPGGYTCT
PHSQ-PWQAALQV-HGRLLCGGVLVHPRWVLTAAHCLK--E-------------------
-----GYRVYLGKH-VLAHVE--AGEQVREVARAIPHPQYQSSPTHLNHDHDIMLLELKS
SVQLTRHIQTLPLSRQHCLPPGTCCRVSGWGTTTSPQVTYPQTLQCANIELRSDEECH--
RVYPGK-ITPNMLCAGTKEGGNDSCEGDSGGPLVCNGKLHGIISWGDFPCGQPNRPGVYT
----RVSQY------VPWIQETIRKGKTWQQEWAKGPQ----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------MGRPRP-RAAKTWMFLLLLGEAWR-VDAWTSL--TKLYAENLL
CVHLN--------------------P------QGWRSNPVPPAAGHSRAQEDKVLGGQEC
RPHSQPWQAALFQ----GKQLLCGG-VLIGGNWI------LTAAHCKKP-----------
KYTV---------------RLGDHSLQKKDGPEQEIPVVQSIPHPCYN-----SSDVEDH
NHDLMLLQLRDQASLGPKVKPINLADHCTQPG-QTCIISGWGTVTSPRE-----------
-------NFPDTLN-CAEVK--------IFPQ-------KKCEDAYPG-QITDGMVCAGS
S-------KGADTC---QG---------DSGGP---------LV-CNGA-LQGIT--SWG
SD-PCGRSDRPGVYTNICRYLDWIKKTIGSKG----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------KNEEKIIGGHMC
IPNSQPWQAALLTN----RQFRCGG-VLLSNRWV------LTAAHCNHW-----------
NLLV---------------VLGKHNIRPLEPSQQSVGVERRVPHLSY--------NPRTS
NNDIMLLYLEKPVKLTNQVQPIQLAKNCASPG-TDGLVSSWGTVSSPF------------
------------------------------------------------------------
------------------G---------NSGGP---------LV-CNGV-LQGLV--SWD
ME-HCTLPGYPGVYTNLCHYQTWILNEMQKN-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------TTV-KMPATKTLA------TRALAVWL-LLVTARAEEQDKVVHGGPC
DSDSHPFQAALYN----SGHLLCGG-VLIHPSWV------LTAAHCKKP-----------
NLQV---------------YLGKHNLQQREASQQQISVAHTVIHPRY--------DPASH
DNDIMMVQLEVPVKLSEKIHPLPLSRNCTAKD-SSCSILGWGKME--NG-----------
-------DLPDTIQ-CANVK--------LVSH-------SECERAYPG-HITRNMVCAGD
EK------EGMDSC---QG---------DSGGP---------LL-CGGR-LRGIV--SWG
NI-PCGSEKKPGVYTDVCRYRGWIRNTIRSKP----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------MKLG--------L--------------LCA-LLSLLAG-HGWADTRAIGAEECR
PNSQ-PWQAGLFH-LTRLFCGATLISDRWLLTAAHCHK------P---------------
-----YLWVRLGEH-HLWKWEG--PEQLFRVMDFFPHPGFNKDLSANDHNDDIMLIRLPR
QARLSPAVQPLNLS-QTCVSPGMQCLISGWGAVTSPKALFPVTLQCANISILENKLCH--
WAYPGH-ISDSMLCAGLWEGGRGSCQGDSGGPLVCNGTLAGVVSGGGEPCSRPRRPAVYT
----SVCHY------FDWIQETMEN-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------MKNLLVVLSLMAAAWAEEQNKLVHGGPC
EKTRHPYQAALYT----AGHLLCGG-VLIHPLWV------LTAAHCKKP-----------
NLQV---------------FLGKHNLRQRESSQEQSSVVRAVIHPGY--------DASTH
DQDIMLLRLAHPAKLSELIQPLPLERDCSANY-TSCHILGWGKTA--D------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----MW---PLAAA-IASLTVALSGGISQEYPKIL------NG-TNGTSGFLPGGYTCL
PHSQ-PWQAALLV-RGRLLCGGVLVHPKWVLTAAHCLKD---------------------
-----GYKVYLGKH-ALGRVE--AGEQVREVVRSIPHPEYQISSTHLNHDHDIMLLELES
PVQPTGHVRVLPLSHHDCLPPGTCCRVSGWGTTTSPQVSYPKTLQCANIELRSDGECR--
QVYPGK-ITPNMLCAGTKEGGKDSCEGDSGGPLVCNGTLHGIISWGDFPCGQPNRPGVYT
----RVSKY------VLWIRETIRKHNTPEHKWTKGPQ----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------MGRPPP-CAIQKWIFLFLLMGTWA-------------------
--------------------------------------------GLTKAQGSKVLEGQEC
KPHSQPWQTALFQ----GPRLVCGG-VLVGDKWI------LTAAHCKKQ-----------
KYSV---------------RLGDHSLQSRDKPEQEIQVAQSIQHPCYN-----SSNPEDH
SHDVMLIRMRHSANIGDKVKSIKLAEECPKVG-QKCTISGWGTVTSPRE-----------
-------NFPDTLN-CAEVE--------IFSQ-------SKCEKAYPG-KVTEGMVCAGS
S-------NGADTC---QG---------DSGGP---------LV-CNGV-LQGIT--SWG
SD-PCGKPEKPGVYTNICYYSDWIHKTMNNRD----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------MRLA--------F--------------LCA-LLSLLGG-QGWADTRAIGAKECR
PNSQ-PWQAGLFH-LTHLFCGATLISDRWLLTAAHCRK------R---------------
-----YLWVRLGEH-HLWKWEG--LEQLFRATDFFPHPGFNQDLTAQDHNNDIMLVRLPR
KAHLGPAVQPLNLS-QTCVSPGTQCLISGWGAVSSPKVEYPLTLRCANISILEPRLCR--
RAYPGH-ISDSMLCAGLWEGGRGSCQGDSGGPLVCNGTLAGVVSGGSEPCSRPRRPAVYT
----SVCHY------LDWIQETMEDN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----KGRG--------LC--------------CSP-LWFLSPR-HSWADTRAIGAKECP
RNSQ-PWQAGLFF-LTRLFCGATLISDRWLLTAAHCRK------S---------------
-----RLWVRLGEH-HLWQWEG--PEQLFLARDFFPHPGFNSDLSANDHNHDIMLIRLPR
RARLGPAVQPLNIS-KTCISPGTKCLISGWGAVSSPKAQFPLTLQCANINILEPTLCH--
WAYPGH-ISDTMICAGQWEGGRGSCQGDSGGPLVCNGTLAGVVSGGGEPCSRPQRPAVYT
----GTCHY------YDWIKKTMEEN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------MA------LKTLTVVLVLLAGALAEEQEKLVHGGPC
DRHSHPYQAALYS----SDHLLCGG-VLIHPEWV------LTAAHCKKE-----------
KLHI---------------YLGKHSLRNSLNTE-KISVVKTVVHPGF--------NPATH
DQDIMLLRLSEPAKLSDLIQPLALQKDCRARS-TSCHILGWGKTE--EG-----------
-------VFPDTIQ-CAYVQ--------LVSR-------EVCEHAYPG-QITRNMVCAGD
QK------EGKDAC---QG---------DSGGP---------LV-CGGL-LRGLV--SWG
NV-PCGSKEKPGVYTDVCRYVSWIQRIIRGD-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------MSLRVSVF---------------------------------------------
-----------LFLPE-PKARVPRML----LLLTALQIWALAGVQSQE-DENKIIGGYSC
IQHSQPWQAALLAG--PARRLHCGG-ALLSEHWA------ITAAHCSRP-----------
ILRV---------------ALGKHNLKKREATQQVLRVARQVPHPQY--------NPRTH
DNDLMLLRLERPARLGSAVRPIPVARTCAGPQ-TPCRVSGWGTTSSPIA-----------
-------RYPNALQ-CVNIS--------ITSRQQ-------CQQAYSG-AITDGMVCAGT
PE------GGKDSC---Q------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------MGHPPP-QAAQAWIFLLLLVGAWA-------------------
--------------------------------------------GLSRAQGSKVLEGQEC
EPHSQPWQTALFQ----GDRLVCGG-VLVGARWI------LTAAHCKKQ-----------
KYSV---------------RLGDHSLQSRDEPEQEIQVAESIQHPCFN-----SSNPEDH
RHDLMLVRMRRPASIGAKVRPIKLSNRCPHVG-QKCTISGWGTVTSPRE-----------
-------NFPDTLN-CAEVD--------IFSQ-------NKCKDAYPG-KITAGMVCAGN
S-------NGADTC---QG---------DSGGP---------LV-CDGR-LQGIT--SWG
SD-PCGRPERPGVYTNVCRYTDWIQKTMGNRP----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------SGLC--L----------S
HIQL---------------RLGEHSLSSFSGCEQFSAAQNITPHCKFYASG---LDSRNY
ENDIMLIRISPPAVYTDCVQPLSLTDTCPTPG-THCTVMGWGTTTSPEE-----------
-------TYPDTPQ-CVDID--------IVSG-------EDCQAEYPG-KVTENMLCAGV
PE------GGKDSC---QG---------DSGGP---------LV-CDGK-LQGLV--SWG
DH-PCAQANKPGVYTSICKYLDWIQKIIAGQ-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------MKLG--------L--------------LCA-LLSLLAG-HGWADTRAIGAEECR
PNSQ-PWQAGLFH-LTRLFCGATLISDRWLLTAAHCRK------P---------------
-----YLWVRLGEH-HLWKWEG--PEQLFRVTDFFPHPGFNKDLSANDHNDDIMLIRLPR
QARLSPAVQPLNLS-QNCVSPGTQCLISGWGAMSSPKALFPVTLQCANISILENKLCH--
WAYPGH-ISDSMLCAGLWEGGRGSCQGDSGGPLVCNGTLAGVVSGGAEPCSRPRRPAVYT
----SVCHY------LDWIQEIMEN-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------G-QVGGETRIIKGYECQ
PHSQ-PWQAALFQ-KSRLLCGATLIAPSWLLTAAHCRKPWVRGLGRRHAP-LPPSSSDHH
LSHLSRYIVHLGEH-NLQRWEG--CEQIRIATESFPHPGFNNSLPNKDHRHDIMLVKMVA
PALITWAVRPLSLS-SHCVTAGTRCLISGWGTTSSPQLHLPHSLRCANISIIEHKECE--
DAYPGN-ITDTMVCASVREEGKDSCQGDSGGPLVCNGSLQGIISWGQDPCAVTKKPGVYT
----KVCKY------VDWVQETMKNN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------TAAQGGDKVLGGKEC
APGSQPWQVALFD----FGRFNCGG-TLLTPRWV------LTAAHCLTR-----------
PIRV---------------RLGEHNLKVLEGQEQLRGVSRAIPHPRY--------RERDH
EDDIMLLKLALPARLTPSVRPLSLPTRCPQPG-DRCVVSGWGLVANSKGEEAGGTDR---
-----------WVG-C--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------VKTLVVALFLTTAACTEFQEKVLYGDPC
EELAHPYQAAVYT----SGHLLCGG-VLVHPQWV------VTAAHCKKP-----------
NLQV---------------FLGKHNLRQRESSQEQSSVTRMVPHPHY--------KPATH
DQDIMMLRLARRPLVSQHIQPLALESNCRANH-STCHILGWGKTA--DG-----------
-------HFPDTIQ-CAYVH--------LVSR-------EXXXXXXXX-XXXXXXXXXXX
XX------XXXXXX---XG---------DSGGP---------LV-CGEH-LRGIV--SWG
NI-PCGSKEKPGVYTDICKYGGWIRSVIRTYG----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------MWLLLTLSFLLASS-AQ-DGDKLLEGDEC
APHSQPWQVALYE----RGRFNCGA-SLISPHWV------LSAAHCQTR-----------
FMRV---------------RLGEHNLRKRDGPEQLRTASRVIPHPRY--------EARSH
RHDIMLLRLVQPARLTPQVRPVVLPTRCPHPG-EACVVSGWGLVSHIEPGT-TR------
-SPQSQVSLPDTLH-CANIS--------IISD-------TSCDKSYPG-RLTNTMVCAGA
EG------RGAESC---EG---------DSGGP---------LV-CGGV-LQGIV--SWG
DV-PCDNTTKPGVYTKVCHYLKWIRETMKRN-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------MGRPSP-AAVWIWMLLLLLSES---------------------
------------------------------------------RAGHLRAQESKVLEGKEC
KPHSQPWQTALFQ----GVRLICGG-VLIEDNWV------LTAAHCQKK-----------
KYTV---------------RVGEHSLKNKDESEQERAVAQSIPHPCYN-----SS-NNDH
SYDLMLIQLRGRVPLGPKVKPIKLADHCPQAG-QKCTISGWGTVTSPRE-----------
-------NFPDTLN-CAEVK--------IIPQ-------HQCEKAYPG-QVTDSMVCASD
S-------SGADTA---FGNSLFYLFIFDSGGP---------LV-CNGV-LQGIT--SWG
SD-PCGRPEKPGVYSKVCHSLDWIKKTIGSRG----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----MW---PLAAV-IAFLTVALSGGISQEYPKIL------NG-TNGTSGFLPGGYTCR
PHSQ-PWQAALLV-QGRLLCGGVLVHPKWVVTAAHCLKDHS-------------------
-----GYRVYLGKH-ALGRAE--AGEQVREVVRSIPHPQYQISSTHLNHDHDIMLLELQS
PVQPTNHIRVLPLSHNDGLPAGTCCRVSGWGTTTSPQVSYPQTLQCANIQLRSDEECR--
QVYPGK-ITPNMLCAGTKEGGKDSCEGDSGGPLICNGTLHGIISWGDFPCGQPNRPGVYT
----RVSRY------VLWIRDTIRKHKTQEQKWTKGPQ----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------TANGREDEEKIIGGYTC
IPNSQPWQAALLAN----RQFRCGG-VLLSNRWV------LTAAHCNHW-----------
NLRV---------------VLGKHNIRLLEPSQQSVGVERRVPHPSY--------SPRTS
NNDLMLLYLEKPVKLTNQVKPIQLAKNCANPG-TDCLVSGWGTVSSPFA-----------
-------RYPSTLQ-CLKIS--------IFSEES-------CKNAYYGKAITPGMVCAGD
KK------GGKDSC---QG---------DSGGP---------LV-CNGV-LQGLV--SWG
ME-HCALPGYPGVYTNLCRYRTWILNEMQKN-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------S---------------------------------------------
-----------QTS---ERVGGWRAFVH--LLSPPHLCLFLAMAQSQG-DENKIIGGYTC
IQNSQPWQAALLAG--PFRRFLCGG-ALLSGRWA------ITAAHCARP-----------
VLHV---------------ALGKHNLRNWEATQQVLRVVRQVPHPQY--------SPRTH
NNDLMLLQLERPARLGRAVRPIAIASSCAGPG-TPCHVSGWGTTSSPIV-----------
-------RYPNSLQ-CVNIN--------ISSDQE-------CRQAYSQ-AITAGMVCAGS
PQ------GGKDSC---QG---------DSGGP---------LV-CKGQ-LQGLV--SWG
ME-RCALPGYPGVYTNLCKYQTWIQKTIQSN-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------ISQDHPKII------NG-TNGTSGFLPGGFTCQ
PHSQ-PWQAALQV-HGQLLCGGVLVHPKWVLTAAHCQKX---------------------
-----XXXXXXXXX-XXXXXX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXSYPQTLQCVNIQLRSDAECR--
QVYPGK-ITPNMLCAGTDEGGKDSCEGDSGGPLLCNGTLHGIISWGDFPCGQPNRPGVYT
----RVSRY------VPWIRGIIRKHTAPDGKGVKGS-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------MGRPPPG-AVMTWLFLFLLWEAW-TA-CGSVL--GCVHAENVW
CVHLNPRW-SSRPC---------HCP------RGRRSNTLPPAAGRARAQMSKVLGGQEC
KPHSQPWQTALFQ----GEQLLCGG-VLVGANWV------LTAAHCKKP-----------
KYTV---------------RLGDHSLQSKDGPEQEMSVLRSFPHPCYD-----SS-SKDN
SHDLMLLRLRGRASLGPKVKPINLTDHCPQAG-QKCTISGWGTVTSPRE-----------
-------NFPDTLN-CADVN--------IINK-------KKCEDAYPG-QVTDSMVCAGN
N-------NGADTC---QG---------DSGGP---------LV-CDGV-LQGIT--SWG
SD-PCGLPHKPGVYSNICRYLDWIKKTMGTKV----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-RNVQFW-------AHLH------------AVPLPV-------LAQTQTFHRIIGGEECV
PHSQ-PWQVALYY-FSDFICGGVLINEWWVLTAAHCIQS---------------------
-----HLQVALGAH-NKTNPM--GHIQYTYAAKICPHRDFDWS----TYNNDIMLLKLAS
QADINDRVAPIPLA-SYLVADNTKCLASGWGSTTSPQETYPDNLKCVSITTASNSVCQ--
ASYPRDTVTDNMLCAGNMAGGEDTCVGDSGGPLVCNGELHGITSWGDFVCGSPNKPGIFA
----KVFNY------IDWINNIMQNEAPCRVVG---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------AQGDGDKVMRGAEC
EPHSQPWQVALFE----RGRFNCGA-SLIAPSWV------LSAAHCQTR-----------
FMRV---------------RLGKHNLRKREVSEPLRTVVQVIPHPGY--------EPLSH
RHDLMLLRLAQPARLSRQVRPVTLPSHCPRPG-EACVVSGWGLVSSNRPGI-TG------
-SSKSKVSLPDTLH-CANIS--------IISD-------ATCSKDYPG-RVWNSMVCAGV
EG------GGTDSC---EG---------DSGGP---------LV-CGGV-MQGIV--SWG
DV-PCNTTTKPGVYTKVCDYLEWIRDTMKRN-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------MGRPPP-AAVWTWMFLL----LLLE------------------
--AWA---------------------------------------GHFLAQENKILDGHEC
KAHSQPWQAGLFQ----GIRLQCGG-VLIGDSWV------LTAAHCKKT-----------
KYTV---------------RLGDHSLQNKERTEQEMAVAQSIPHPCYN-----IS-SGDH
NHDLMLIRLRGRACLGPKVKPIKLTDRCPQVG-QNCTISGWGSITSPRE-----------
-------NFPDTLN-CAEVE--------IFPQ-------KRCEDVYPG-QVTDGMICAGS
N-------SGADTC---QG---------DSGGP---------LV-CGGV-LQGIT--SWG
SD-PCGRPEKPGVYTNICRYLDWIKKTIGSRGRF--------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------M-SP--AAQDGDKVLKGEEC
APHSQPWQVALYE----RGRFNCGA-FLISPRWV------LTAAHCQTR-----------
FMRV---------------RLGEHNLRKRDGPEQVRAVSHIIPHPGY--------EARTH
LHDIMLLRLLQPVRLSSQVRPVPLPTRCPFAG-EGCVVSGWGLLSDNKPGA-TG------
-SRKSQVRLPDALH-CANIS--------IISE-------ASCNKDYPG-RVLPTMVCAGV
EG------GGTDSC---EG---------DSGGP---------LV-CSGA-VQGIV--SWG
DV-PCDTTTKPGVYTKVCSYTEWIRENMKTRN----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MAQSPE-NDNKIIGGYTC
IQNSQPWQVALLAG--AGRQFLCGG-VLLSDQWV------ITAAHCARP-----------
ILYV---------------AVGKHNLRRWEATQQILPVQRQVPHPGY--------NSRTH
NNDLMLLRLRQPLRIGRAVRPIPLAQSCASKG-TPCLVSGWGTISSPIA-----------
-------RYPNALQ-CVNIN--------IMSDQQ-------CQQAYPG-AITAGMVCAGV
PQ------GGKDSC---QG---------DSGGP---------LV-CGGK-LQGLV--SWG
ME-RCALTGYPGVYTNLCKYRSWIQRTMQGQRP---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------MKLG--------L--------------LCA-LLSLLAG-HGWADTRAIGAEECR
PNSQ-PWQAGLFH-LTRLFCGATLISDRWLLTAAHCRK------P---------------
-----YLWVRLGEH-HLWKWEG--PEQLFRATDFFPHPGFNKDLSANDHNDDIMLIRLPR
QARLSPAVQPLNLS-QTCVSPGTQCLISGWGAVSSPKALFPVTLQCANISILENKLCH--
WAYPGH-ISESMLCAGLWEGGRGSCQGDSGGPLVCNGTLAGVVSGGAEPCSRPRRPAVYT
----SVCHY------LDWIQEIMES-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------ISL--------------------------------------------------
-----------RVLCG-TLSPLLRMF----FLLTILQILAVAVVQSQE-DNNKIIGGSPC
IQNSQPWQAALLAG--PGHRFICGA-VLLSDQWA------VTAAHCARP-----------
ILRV---------------ALGKNNLKRWEATQQVLRVVRQVPHPQY--------DSRTH
NNDLMMLQLRAAAWEAVRL-----TVAV---C-SPGSCSGSGGTIASPA-----------
-------RYPDSLQ-CVNIS--------ILSAQM-------CRQSYSE-AITPGMVCAGV
PE------GGKDSC---QG---------DSGGP---------LV-CRGQ-LQGLV--SWG
ME-RCALPGYPGVYTNLCRYQNWIQERIRGK-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----MW---PLAAV-IAFLTVALSGGISQEYPKIL------NG-TNGTSGFLPGGYTCR
PHSQ-PWQAALLV-QKRLLCGGVLVDPKWVLTAAHCLKE---------------------
-----GYRVYLGKH-ALGRVE--AGEQVREVVRSIPHPQYQISPTHLKHDHDIMLLELHS
PVQLTNHIRVVPLS-QDCLPAGTCCRVSGWGTTTSPQVSYPPTLQCANIQLRSDEECH--
QVYPGK-ITPNMLCAGTEEGGKDSCEGDSGGPLICNGTLHGIISWGDFPCGQPNRPGVYT
----RVSQY------VVWIRETIQKHRTQEWKRTKGKGP----Q----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
-------------------PSTPKML----LLLAALQILAVGMAQNQM-DENKIIGGYTC
TQNSQPWQAALLAG--PGRRFLCGA-VLLSEQWA------ITAAHCAHP-----------
ILRV---------------ALGKHNLRRWEATEQVLNVARQVIYPSY--------NAQTH
DNDLMLLQLQPPARLGKAVQPISVANSCARAG-TTCRVSGWGTISSPV------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------MPTKMLT------VKTLALCLILAKSAWSEDQDKVVHGGPC
LKNSHPFQAALYT----SGHLLCGG-VLVGPQWV------LTAAHCKKP-----------
NLEV---------------YLGKHNLRQTETFQRQISVDRTIVHPRY--------NPQTH
DNDIMMVHLKRPVKFSQRIQPLPLKKDCSEKN-PDCQILGWGKME--NG-----------
-------EFPDTIQ-CADVQ--------LVSR-------EECERAYPG-KITRSMVCAGD
KR------EGNDSC---QG---------DSGGP---------LV-CGGH-LRGIV--SWG
DM-PCGSKEKPGVYTDVCTHIRWIQNIIRNK-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------MPMKMLT------MKMLALCLVLAKSAWSEEQDKVVHGGPC
LKDSHPFQAALYT----SGHLLCGG-VLIGPQWV------LTAAHCKKP-----------
NLEV---------------FLGKHNLRQTETFQRQISVDTTIVHPRY--------NPETH
DNDIMMVHLKTPVKFSRKIQPLPLKKDCFEEN-SNCQILGWGKME--NG-----------
-------DFPDTIQ-CADVH--------LVPR-------EQCERAYPG-KITQSMVCAGD
MK------EGNDSC---QG---------DSGGP---------LV-CGGH-LRGLV--SWG
DM-PCGSKEKPGVYTDVCTQIRWVQSVLRNKWL---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------MKPG-------LT--------------L-V-LFSLLAG-HCGADTRAVGARECV
RNSQ-PWQAGLFY-LTRQLCGATLISDQWLLTAAHCRK------P---------------
-----YLWVRLGEH-HLWQWEG--PEQLLLATDFFPHPGFNPDLSANDHNDDIMLIRLPR
KVRLTPAVQPLNLT-ESRPSVGTQCLISGWGSVSSSKLQYPMTLQCANISILDNKLCR--
WAYPGH-ISEKMLCAGLWEGGRGSCQGDSGGPLVCEGTLAGIVSGGSEPCSRPRRPAVYT
----NVFDY------LEWIESTMEKN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------MGRPPP-CAIQPWILLLLFMGAWA-------------------
--------------------------------------------GLTRAQGSKILEGREC
IPHSQPWQAALFQ----GERLICGG-VLVGDRWV------LTAAHCKKQ-----------
KYSV---------------RLGDHSLQSRDQPEQEIQVAQSIQHPCYN-----NSNPEDH
SHDIMLIRLRNSANLGDKVKPVQLANLCPKVG-QKCIISGWGTVTSPQE-----------
-------NFPNTLN-CAEVK--------IYSQ-------NKCERAYPG-KITEGMVCAGS
S-------NGADTC---QG---------DSGGP---------LV-CDGM-LQGIT--SWG
SD-PCGKPEKPGVYTKICRYTTWIKKTMDNRD----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------MKKLMVVLSLIAAAWAEEQNKLVHGGPC
DKTSHPYQAALYT----SGHLLCGG-VLIHPLWV------LTAAHCKKP-----------
NLQV---------------FLGKHNLRQRESSQEQSSVVRAVIHPGY--------DAATH
DQDIMLLRLARPAKLSELIQPLPLERDCSANT-TSCHILGWGKTA--DG-----------
-------DFPDTIQ-CAYIH--------LVPR-------EECEHAYPG-QITQNMLCAGD
EK------YGKDSC---QG---------DSGGP---------LV-CGDH-LRGLV--SWG
NI-PCGSKEKPGVYTNVCRYTNWIQKTIQAK-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------MGRPPP-CAIQTWILLFLLMGAWA-------------------
--------------------------------------------GLTRAQGSKILEGQEC
KPHSQPWQTALFQ----GERLVCGG-VLVGDRWV------LTAAHCKKD-----------
KYSV---------------RLGDHSLQKRDEPEQEIQVARSIQHPCFN-----SSNPEDH
SHDIMLIRLQNSANLGDKVKPIELANLCPKVG-QKCIISGWGTVTSPQE-----------
-------NFPNTLN-CAEVK--------IYSQ-------NKCERAYPG-KITEGMVCAGS
S-------NGADTC---QG---------DSGGP---------LV-CNGV-LQGIT--SWG
SD-PCGKPEKPGVYTKICRYTNWIKKTMGKRD----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------MGHPSP-AAVWTWMFLLLLLEAWA-------------------
--------------------------------------------GHLRAQESKVLGGQEC
KPHSQPWQTALFQ----GIRLLCGG-VLIDDNWV------LTAAHCKKQ-----------
KYTV---------------RLGDHSLKNKDRSEQEMAVAQSIQHPCYN-----GS-NEDH
SHDLMLIRLRGRASLGPTVKPISLTDHCPEVG-QKCTISGWGTVTSPRE-----------
-------NFPDTLN-CAEVE--------IFPQ-------KKCKDVYPG-EVTDAMICAGD
S-------NGADSC---QP---------TQERP---------LL-CLAA-PGEAQRGHHG
RI-PSLVPAVP--ATNLSPAICWPRR----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------MSLR---------------------------------------------
-----------VLGSS-TWPSAPKMF----LLLAALQVLAVAMTRSQG-DENKIIGGYTC
ARSSQPWQAALLVG--PGRRFLCGG-ALLSDQWV------ITAAHCGRP-----------
ILRV---------------ALGKHNLKRWEATQQVLRVVRQVTHPSY--------NSRTH
DNDLMLLQLQQPARIGRAVRPIEVAQACASPG-TSCRVSGWGTTSSPVA-----------
-------RYPTSLQ-CVNIN--------ISPDEV-------CGKAYPG-AIKPGMVCAGV
PQ------GGKDSC---QG---------DSGGP---------LV-CKGK-LQGLV--SWG
ME-RCALPGYPGVYTSLCKYRSWIEETMRGK-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------MG------MKTLIVALVLMAAAWAEEQNKVLHGGPC
EQTSHPYQAALYM----SGHLLCGG-VLIHPLWV------LTAAHCKKP-----------
NLQV---------------YLGKHNLQQRESFQEQSSVVRAVVHPGY--------NAATH
DQDIMLLRLARPARFSERIQPLPLEEDCWANH-ASCHILGWGKTA--DG-----------
-------GFPNTIQ-CAYIH--------LVSR-------EECERAYPN-QITQNMVCAGD
EK------YGKDSC---QG---------DSGGP---------LV-CGDR-LRGLV--SWG
NV-PCGSKEKPGVYTDVCRYGRWIRKTIQGN-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------M----QR
LRRLQDWKSSGTGLA---------------A--------------AKEPGARPSP-----
LQAMRILQL-------------------------IM-LALAT-G-LVGGETRIIRGFECK
PHSQ-PWQAALFE-KTRLLCGATLIAPSWLLTAAHCRKP---------------------
-----RYIVHLGEH-NLQKQDG--CEQTRTATESFPHPGFNNSLPNKDHRNDIMLVKMAS
PAFITWAVRPLTLS-SRCVTAGTSCLISGWGSTSSPQLRLPHSLRCANITIIEHQKCE--
NAYPSN-ITDTMVCASVQEGGKDSCQGDSGGPLVCNHSLQGIISWGQDPCAITRKPGVYT
----KVCKY------VDWIQETMKNN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------M----RR
LRWLKDWKSSGPGPA---------------A--------------VKEPGPCPAP-----
LQAMMILRF-------------------------IT-LALVT-G-HVRGETRIIKGYECP
PHSQ-PWQVALFQ-KTRLLCGATLIAPRWLLTAAHCRKP---------------------
-----SYEVILGEH-NLQRQDG--CEQRRTATESFPHPGFNNSLPNKDHRNDIMLVKMSA
PALITRAVRPLSLP-SHCVTAGTRCLISGWGTTSSPQLRLPHTLRCANISIIEHQECE--
SAYPGN-ITDTMLCASVKKEGKDSCQGDSGGPLVCNGSLQGIISWGQDPCAVTRKPGVYT
----KVCKY------VDWIQETMNNN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------MWLLLTLSFLLASS-AQ-DGDKLLEGDEC
APHSQPWQVALYE----RGRFNCGA-SLISPHWV------LSAAHCQTR-----------
FMRV---------------RLGEHNLRKRDGPEQLRTASRVIPHPRY--------EARSH
RHDIMLLRLVQPARLTPQVRPVVLPTRCPHPG-EACVVSGWGLVSHIEPGT-TR------
-SPQSQVSLPDTLH-CANIS--------IISD-------TSCDKSYPG-RLTNTMVCAGA
EG------RGAESC---EG---------DSGGP---------LV-CGGV-LQGIV--SWG
DV-PCDNTTKPGVYTKVCHYLKWIRETMKRN-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---MTILRL-------------------------IT-LALVT-G-HVGGETRIIKGYECK
PHSQ-PWQVALFQ-KTRLLCGATLIAPRWLLTAAHCRKPWVSLTSPPPHV-SLCLSCSDH
GLSLSNYIVHLGEH-NLQRRDG--CEQTRTATESFPHPGFNDSLPNKDHRNDIMLVKMAA
PAAITWAVRPLTLS-SRCVTAGTRCLISGWGTTSSPQLLLPHSLRCAKISIIEHRECE--
DAYPGN-ITDTMVCASVKEEGKDSCQGDSGGPLVCNNSLQGIISWGQDPCAVTKKPGVYT
----KVCKY------VDWIQETMKNN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------MSLR---------------------------------------------
-----------VLVSV-TSP---PMF----LLLTALQVLAIGMTQSQE-DDNKIIGGYTC
IQNSQPWQVALLAG--AGRRFLCGG-ALLSDQWV------ITAAHCARP-----------
ILRV---------------ALGKHNLRRWEATQQVLRVTRQVAHPSY--------NPRAH
NNDLMLLRLERPARLGRAVKTIPVAQSCASPG-TPCLVSGWGTTSSPIA-----------
-------RYPNSLQ-CVNIN--------VFQNQT-------CQQAYPG-AITAGMVCAGV
PQ------GGKDSC---QG---------DSGGP---------LV-CRGQ-LQGLV--SWG
ME-RCALPGYPGVYTNLCKYQNWIQETMEGRW----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------MA------MKMLMVALVLVAAARAEEQNKVLHGGPC
EQTSHPYQVALYV----SGHLLCGG-VLIHPLWV------LTAAHCKKP-----------
NLQV---------------YLGKHNLQQRESFQEQSSVVRTVVHPGY--------NAATH
DQDIMLLRLSHPARLSEHIQPLALERDCSANY-TSCHILGWGKTA--EG-----------
-------DFPNTIQ-CAYLH--------LVPR-------KECERAYPG-QITQNMVCAGD
EK------YGKDSC---QG---------DSGGP---------LV-CRDH-LRGLV--SWG
NV-PCGSKEKPGVYTDVCRYGHWIQKTIQAN-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------ISRDYPKIL------NG-TNGTNGFLPGGYTCL
PHSQ-PWQAALLV-RGRLLCGGVLVHPKWILTAAHCRKD---------------------
-----GYTVHLGKH-ALGRVE--IGEQAMEVVRSIPHPEYQVSPTHLNHDHDIMLLELKS
PVQLSSHIRPLPLSPDDCLPTGTCCRVSGWGTTTSPQVNYPKTLQCANIELRSDEECR--
QVYPGK-ITANMLCAGTKEGGKDSCEGDSGGPLVCNGKLYGIISWGDFPCGQPNRPGVYT
----RVSKY------LHWIWETIRNTPKQ--RWTKNTQ----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------VTMKTTTMT------VKMLALCLVLAKSAWTEEQDKVVHGVPC
MKNSHPFQAALYT----SGHLLCGG-VLIDPQWV------LTAAHCKKP-----------
NLEV---------------HLGKHNLRQTESFQRRISVDRTIVHPRY--------NPDTH
DNDIMMLHLRNPVKFSRKIMPLPLKKDCSKEN-PSCQILGWGKTE--NG-----------
-------DFPDTLQ-CADVQ--------LVSR-------DECERAYPG-KITRNMVCAGN
KK------EGNDSC---QG---------DSGGP---------LV-CGDR-LRGLV--SWG
DL-PCGSKKKPGVYTDVCSYTRWIQNIIKNKWL---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------M----QR
LRWLQDWKSSGRGLA---------------A--------------AKEPGARPSP-----
LQAMRILQL-------------------------IM-LALAT-G-LVGGETRIIKGFECK
PHSQ-PWQAALFE-KTRLLCGATLIAPSWLLTAAHCRKP---------------------
-----RYIVHLGEH-NLQKQDG--CEQTRIATESFPHPGFNNSLPNKDHRNDIMLVKMAS
PAFITWAVRPLTLS-SRCVTAGTSCLISGWGSTSSPQLRLPHSLRCANITIIEHQKCE--
NAYPGN-ITDTMVCASVQEGGKDSCQGDSGGPLVCNHSLQGIISWGQDPCAITRKPGVYT
----KVCKY------VDWIQETMKNN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------MGCPRP-RAAKTWMFLLLLGEAWA-------------------
--------------------------------------------GHSRAQENKVLGGQEC
RPHSQPWQAALFQ----GKQLLCGG-VLIGGNWI------LTAAHCKKP-----------
KYTV---------------RLGDHSLQNKDGPEQEIPVAQSIPHPCYN-----SSDVEDH
NHDLMLLQLREQASLGPKVKPISLADHCTQPG-QMCIISGWGTVTSPRE-----------
-------NFPDTLN-CAEVK--------IFPQ-------KKCEDAYPG-QITDGMVCAGS
S-------KGADTC---QG---------DSGGP---------LV-CNGA-LQGIT--SWG
SD-PCGRSDRPGVYTNICRYLDWIKKTIGSKG----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------MKLG--------L--------------LCA-LLSLLAG-HGWADTRAIGAEECR
PNSQ-PWQAGLFH-LTRLFCGATLISDRWLLTAAHCRK------P---------------
-----YLWVRLGEH-HLWKWEG--PEQLFRVTDFFPHPGFNKDLSANDHNDDIMLIRLPR
KARLSPAVQPLNLS-QTCVSPGTQCLISGWGAVSSPKALFPVTLQCANISILENKLCH--
WAYPGH-ISDSMLCAGLWEGGRGSCQGDSGGPLVCNGTLAGVVSGGAEPCSRPRRPAVYT
----SVCHY------LDWIQEIMEN-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------MGHPLP-RTALNWMLLLSLLGAWARGGVCW-------HVGSLP
A-----PQ-APWLW---------HRL------PGQSPTPVPSATGLCTAQGSKVLEGQEC
EAHSQPWQTALFQ----GGRLICGG-VLVGAGWV------LTAAHCKK------------
KYMV---------------RLGDHSLQSKDEPEQTMSVAQSIQHPCYN-----SSNVEDH
SHDLMLVRLGRQASLGAKVKPIQLADRCAQVG-QTCTVSGWGTVTSPRE-----------
-------NFPDTLN-CAQVQ--------IFSQ-------KR-------------------
------------------G---------DSGGP---------LV-CDGR-LQGIT--SWG
SD-PCGRPEKPGVYTNICRYRDWIIKTMGSG-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------MKKLMVVLSLVAAAWAEEQNKLVHGGPC
DKTSHPYQAALYT----SGHLLCGG-VLIHPLWV------LTAAHCKKP-----------
NLQV---------------FLGKHNLRQRESSQEQSSVVRAVIHPGY--------DAATH
DQDIMLLRLARPAKLSELIQPLPLERDCSANT-TSCHILGWGKTA--DG-----------
-------DFPDTIQ-CAYIH--------LVPR-------EECERAYPG-QITQNMLCAGD
EK------YGKDSC---QG---------DSGGP---------LV-CGDH-LRGLV--SWG
NI-PCGSKEKPGVYTNVCRYTNWIQKTIQAK-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------PLVPL---------------V--------------PRRTWGLPSP-----
LQAMMTLQL-------------------------IM-FALVT-G-HVGGETRIIKGYECP
PHSQ-PWQAALFQ-KTRLLCGATLIAPRWLLTAAHCRKP---------------------
-----RYVVRLGAH-SLQRQEG--CEQTRTATESFPHPDFNN-----NHRNDIMLVKMRT
PAHLTWALRPLTVS-PCCVPAGANCLISGWGTMSSPQLHLPRTLRCANVTIIKHGECE--
DAYPGN-ITDTMVCASVRKEGKDSCQGDSGGPLVCNGSLQGIISWGQDPCAVSKKPGVYT
----KVCKY------VDWIQKTMENN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------MSLR---------------------------------------------
-----------VLGSG-TRPSAPKML----LLLAALQVLAVAMTRSQE-DENKIIGGYTC
ARSSQPWQAALLAG--PGRRFLCGG-TLLSDRWV------ITAAHCGRL-----------
ILRV---------------ALGKHNLKRWEATQQELRVVRQVTHPNY--------NSRTH
DNDLMLLQLQQPARMGRAIRPIEVAQACASPG-TSCRVSGWGTTSSPIA-----------
-------RYPTSLQ-CLNIN--------ISPDEV-------CRKAYPG-AITPGMVCAGV
AQ------GGKDSC---QG---------DSGGP---------LV-CKGK-LQGLV--SWG
ME-RCALPGYPGVYTNLCKYRSWIEETMRGK-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------MKKLMVVLSLVAAAWAEAQNKLVHGGPC
DKTSHPYQAALYT----SSHLLCGG-VLIHPLWV------LTAAHCKKP-----------
NLQV---------------FLGKHNLRQRESSQEQSSVVRAVIHPGY--------DAATH
DQDIMLLRLARPAKLSELIQPLPLERDCSANT-TSCHILGWGKTA--DG-----------
-------DFPDTIQ-CAYIH--------LVPR-------EECEHAYPG-QITQNMLCAGD
EK------YGKDSC---QG---------DSGGP---------LV-CGDH-LRGLV--SWG
NI-PCGSKEKPGVYTNVCRYTNWIQKTIQAK-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------M----QR
LRWLQDWKSSGRGLA---------------A--------------AKEPGARPSP-----
LQAMRILQL-------------------------IM-LALAT-G-LVGGETRIIKGFECK
PHSQ-PWQAALFE-KTRLLCGATLIAPSWLLTAAHCRKP---------------------
-----RYIVHLGEH-NLQKQDG--CEQTRTATESFPHPGFNNSLPNKDHRNDIMLVKMAS
PAFITWAVRPLTLS-SRCVTAGTSCLISGWGSTSSPQLRLPHSLRCANITIIEHQKCE--
NAYPNN-ITDTMVCASVQEGGKDSCQGDSGGPLVCNHSLQGIISWGQDPCAITRKPGVYT
----KVCKY------VDWIQETMKNN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----MW---PLALV-IASLTVALSGGISQESSKVL------N--TNGTSGFLPGGYTCF
PHSQ-PWQAALLV-RGRLLCGGVLVHPKWVLTAAHCLKE---------------------
-----GLKVYLGKH-ALGRVE--AGEQVREVVYSIPHPEYRRSPTHLNHDHDIMLLELQS
PVQLTGYIQTLSLSHNNRLTPGTTCRVSGWGTTTSPQVNYPKTLQCANIQLRSDEECR--
QVYPGK-ITDNMLCAGTKEGGKDSCEGDSGGPLVCNRTLYGIISWGDFPCGQPDRPGVYT
----RVSRY------VLWIRETIRKYETQQQKWLKGPQ----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------MRLG--------C--------------IWA-LLSLLTG-HGWADTRAIGAEECG
PHSQ-PWQAGLFY-HTHLFCGATLISDRWLLTAAHCRK------P---------------
-----YLWVRLGEH-HLWRWEG--PEQLFRVTNFFPHPGFNNDLSANDHNDDIMLIRLPR
PARLSAAVQPLGLS-PTCVRPGTPCLISGWGAVSSPKVRYPMALQCANIRVLEPRLCH--
WAYPGH-ISASMICAGLWEGGRGSCQGDSGGPLVCNGTLAGVVSGGAEPCSRPRRPAVYT
----SVCHY------EAWIRKTMEDN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------MGRPPP-RAALTWMFLLLLGKSWAGEEGCGGLRRGGLYAENLP
C------W-PSQPW---------HCP------RGWRSNPLPPAAGHSRAQENKVLGGQEC
QPHSQPWQAALFQ----GEQLLCGG-VLIGRNWV------LTAAHCKKL-----------
KYTV---------------RLGDHSLQKKDGPEQEIAVVQSIPHPCYN-----SSNVDNH
NHDLMLLQLRDQASLGPKVKPIGLADHCIQPG-QKCTISGWGTTTSPQE-----------
-------NFPDTLN-CAEVK--------IFPQ-------KKCEDAYPE-QITDAMICAGN
N-------NGADTC---QG---------DSGGP---------LV-CDGA-LQGIT--SWG
SD-PCGRPNRPGVYTNICRYLDWIKKIIGSKG----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------MWLLLTLSFLLASTAAQ-DGDKLLEGDEC
APHSQPWQVALYE----RGRFNCGA-SLISPHWV------LSAAHCQSR-----------
FMRV---------------RLGEHNLRKRDGPEQLRTTSRVIPHPRY--------EARSH
RNDIMLLRLVQPARLNPQVRPAVLPTRCPHPG-EACVVSGWGLVSHNEPGT-AG------
-SPRSQVSLPDTLH-CANIS--------IISD-------TSCDKSYPG-RLTNTMVCAGA
EG------RGAESC---EG---------DSGGP---------LV-CGGI-LQGIV--SWG
DV-PCDNTTKPGVYTKVCHYLEWIRETMKRN-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
NLQV---------------YLGKHDLQQQEESQEQSSVAQVVVHPRY--------NSATH
DQDIMLLRLAHPARLSQHVQPLPLEKNCSARH-TSCHIVGWGKTA--DG-----------
-------GFPNTLQ-CAYIH--------LVPH-------EECERAYPG-QITNNMVCAGD
EK------LGKDSC---Q------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------ISQESSKVL------N--TNGTSGFLPGGYTCF
PHSQ-PWQAALLV-QGRLLCGGVLVHPKWVLTAAHCLKE---------------------
-----GLKVYLGKH-ALGRVE--AGEQVREVVYSIPHPEYRRSPTHLNHDHDIMLLELQS
PVQLTGYIQTLSLSHNNRLTPGTTCRVSGWGTTTSPQGMHPHRWLEAPQ-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------MWLLLTLSFLLASTAAQ-DGDKLLEGDEC
APHSQPWQVALYE----RGRFNCGA-SLISPHWV------LSAAHCQSR-----------
FMRV---------------RLGEHNLRKRDGPEQLRTASRVIPHPRY--------EARSH
RNDIMLLRLVQPARLTPQVRPAVLPTRCPHPG-EACVVSGWGLVSHNEPGT-AG------
-SPRSQVSLPDTLH-CANIS--------IISD-------TSCDKSYPG-RLTNTMVCAGA
EG------RGAESC---EG---------DSGGP---------LV-CGGI-LQGIV--SWG
DV-PCDNTTKPGVYTKVCHYLEWIRETMKRN-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------MGRPPP-RAALTWMFLLLLGKSWAACGHPGPL--TKLYAENLP
CVHLSPQW-PSQPW---------HCP------RGWRSNPLPPAAGHSRAQENKVLGGQEC
QPHSQPWQAALFQ----GEQLLCGG-VLIGRNWV------LTAAHCKKP-----------
KYTV---------------RLGDHSLQKKDGPEQEIAVAQSIPHPCYN-----SSDVDDH
NHDLMLLQLRRQASLGSKVKPIGLADHCIQPG-QKCTISGWGTITSPQE-----------
-------NFPDALN-CAEVN--------IFPQ-------KKCEDAYPG-QITDAMVCAGN
N-------NGADTC---QG---------DSGGP---------LV-CDGA-LQGIT--SWG
SD-PCGRPNRPGVYANICRYLDWIKKITGSKG----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------LN------------DVPLPV-------LAQTQAFHRIIGGEECV
PHSQ-PWQVALYY-FSDFICGGVLINKWWVLTAAHCNQS---------------------
-----NLQVLLGAH-NRTKPT--GHKQYTYAAKICPHEEFDWS----TYNNDIMLLKLAS
QADINTRVAPIPLA-SYLVADNTECLASGWGSTTSPQETYPDNLKCVNITTVSNSVCQ--
ACYPSDIITDNMLCAGNMAGGEDTCVGDSGGPLVCNGELHGITSWGDYVCGCPNKPGIFA
----KVFNY------LNWISDIIQNESPCRVVG---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------MA------VKMLVIALVLVAAAQAEEKDKVLHGGPC
EQTSHPYQAALYT----AGHLLCGG-VLIHPLWV------LTAAHCKKP-----------
NLQV---------------FLGKHNLQQREFFQEESSVIRTVAHPGY--------NAATH
DQDIMLLRLSRPPRLSDHIQPLALERDCSANH-TSCHILGWGKMA--DG-----------
-------EYPDTIQ-CAYVH--------LVSR-------EKCDHAYPG-QITQNMVCAGD
EK------HGKDSC---QG---------DSGGP---------LV-CGDR-LRGLV--SWG
NV-PCGSKEKPGVYTDVCRYGHWIQRVIQAN-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------MGRPSP-AAVWIWMLLLLLLES---------------------
------------------------------------------QAGHVRAQENKVLEGKEC
KPHSQPWQTALFQ----GVRLICGG-VLIEDNWV------LTAAHCQKK-----------
KYVV---------------RMGEHSLKKKDESEQERAVARSIPHPCYN-----NS-KNDH
SYDMMLIQLRGRVSLGPKVKPIKLADHCPQVG-QKCTISGWGTVTSPRE-----------
-------KFPDTLN-CAEVK--------IIPQ-------DQCEKAYPG-QVTDSMVCASD
S-------SGADTC---QG---------DSGGP---------LV-CNGV-LHGIT--SWG
SD-PCGRPEKPGVYSKVCRSLDWIKKTIGRRG----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------MWLLLTLSFLLASTAAQ-DGDKLLEGDEC
APHSQPWQVALYE----RGRFNCGA-SLISPHWV------LSAAHCQSR-----------
FMRV---------------RLGEHNLRKRDGPEQLRTASRVIPHPRY--------EARSH
RNDIMLLRLVQPARLTPQVRPAVLPTRCPHPG-EACVVSGWGLVSHNEPGT-AG------
-SPRSQVSLPDTLH-CANIS--------IISD-------TSCDKSYPG-RLTNTMVCAGA
EG------RGAESC---EG---------DSGGP---------LV-CGGI-LQGIV--SWG
DV-PCDNTTKPGVYTKVCHYLEWIRETMKRN-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------MSLR---------------------------------------------
-----------GLVSV-TQPLAPRMF----LLLTALQVLAVGMTQSQE-DENKIIGGYTC
TQNSQPWQAALLAG--PGRRFTCGG-ALLSSQWV------ITAAHCGRP-----------
TLWV---------------ALGKHNLRRWEATQQVLRVARQVTYPNY--------DARKH
NNDLMLLKLEKPARLGRAVKTIPIAQSCASPG-TLCRVSGWGTTSSPIV-----------
-------RYPSTLQ-CVSIY--------IAQNQT-------CQQAYPG-AITAGMVCAGV
PQ------GGKDSC---QG---------DSGGP---------LV-CGGQ-LQGLV--SWG
ME-HCAQPGYPGVYTNLCKYQNWIQEVMQGR-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----MW---PLALV-IASLTVALSGGISQESSKVL------N--TNGTSGFLPGGYTCF
PHSQ-PWQAALLV-RGRLLCGGVLVHPKWVLTAAHCLKE---------------------
-----GLKVYLGKH-ALGRVE--AGEQVREVVYSIPHPEYRRSPTHLNHDHDIMLLELQS
PVQLTGYIQTLSLSHNNHITPGTTCRVSGWGTTTSPQVNYPKTLQCANIQLRSDEECR--
QVYPGK-ITDNMLCAGTKEGGKDSCEGDSGGPLVCNRTLYGIISWGDFPCGQPDRPGVYT
----RVSRY------VLWIRETIRKYETQQQKWLKGPQ----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------MGRPPP-CAIQPWILLLLFMGAWA-------------------
--------------------------------------------GLTRAQGSKILEGREC
IPHSQPWQAALFQ----GERLICGG-VLVGDRWV------LTAAHCKKQ-----------
KYSV---------------RLGDHSLQSRDQPEQEIQVAQSIQHPCYN-----NSNPEDH
SHDIMLIRLQNSANLGDKVKPVQLANLCSKVG-QKCIISGWGTVTSPQE-----------
-------NFPNTLN-CAEVK--------IYSQ-------NKCERAYPG-KITEGMVCAGS
S-------NGADTC---QG---------DSGGP---------LV-CDGM-LQGIT--SWG
SD-PCGKPEKPGVYTKICRYTTWIKKTMDNRD----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------MKKLILTLVLITAAWTEDQNKLVHGDPC
SKNSHPFQAALYT----EGHLLCGG-VLIHPQWV------LTAAHCKNT-----------
NLQV---------------FLGKHNLQQRESSQQQSSVVKTVIHTGY--------NAATH
DQDIMLLYLKHPVTLSEHIQPLPLERDCSADN-TNCHILGWGKTA--D------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------MKLG-------LT--------------L-V-LFSLLAG-HCGADTRAVGARECV
RNSQ-PWQAGLFY-LTRQLCGATLINDQWLLTAAHCRK------P---------------
-----YLWVRLGEH-HLWRWEG--PEQLLLVTDFFPHPGFNPDLSANDHNDDIMLIRLPR
KVRLTPAVQPLNLT-ESRPPVGTQCLISGWGSVSSSKLQYPMTLQCANISILDNKLCR--
WAYPGH-ISEKMLCAGLWEGGRGSCQGDSGGPLVCEGTLAGIVSGGSEPCSRPRRPAVYT
----NVFDY------LEWIESTMEKN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
MRRLKS---DWKLST---------------E--------------TREPGARPAL-----
LQARMILRL-------------------------IA-LALVT-G-HVGGETRIIKGYECR
PHSQ-PWQVALFQ-KTRLLCGATLIAPKWLLTAAHCRKP---------------------
-----HYVILLGEH-NLEKTDG--CEQRRMATESFPHPDFNNSLPNKDHRNDIMLVKMSS
PVFFTRAVQPLTLS-PHCVAAGTSCLISGWGTTSSPQLRLPHSLRCANVSIIEHRECE--
KAYPGN-ITDTMLCASVRKEGKDSCQGDSGGPLVCNGSLQGIISWGQDPCAVTRKPGVYT
----KVCKY------FNWIHEVMRNN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------MKLG-------LT--------------V-V-LFSLLAG-HCGADTRTVGARECE
RNSQ-PWQAGLFY-LTRQLCGATLINDQWLLTAAHCRK------P---------------
-----YLWVRLGEH-HLWRWEG--PEQLLLVTDFFPHPGFNPDLSANDHNDDIMLIRLPR
KVRLTPAVQPLNLT-ESQPPVGSQCLISGWGSVSSSKLQYPMTLQCANISILDNKLCR--
WAYPGH-ISEKMLCAGLWEGGRGSCQGDSGGPLVCEGTLAGIVSGGSEPCSRPRRPAVYT
----SVSDY------LEWIESTMEKN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------MKLG--------L--------------VCA-LLAVLAG-TSRADTRAIGAQECQ
PNSQ-PWQAGLFY-RTHLLCGASLISDRWLLTAAHCHK------R---------------
-----QLWARLGEH-HLWRWEG--PEQLFRVKDFFPHPGFNKDLSAQDHNDDIMLIRLPR
QARLGPAVQPLNLS-QTCVSPGTQCLISGWGAVSSPLVQYPLTLQCANISILEPILCH--
WAYPGH-ITKSMLCAGLWEGGRGSCQGDSGGPLVCNGTLAGVVSGGSEPCSRPRRPAVYT
----SVCHY------VDWIRKTMEDN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
MRRPKS---DWKLST---------------E--------------TREPGARPAL-----
LQATMILRF-------------------------IA-LALVT-G-HVGGETRIIKGYECK
PHSQ-PWQVALFQ-KTRLLCGATLIAPKWLLTAAHCRKP---------------------
-----HYVILLGEH-NLEKTDG--CEQRRMATESFPHPDFNNSLPNKDHRNDIMLVKMSS
PVFFTRAVQPLTLS-PHCVTAGTSCLISGWGTTSSPQLRLPHSLRCANVSIIEHKECE--
KAYPGN-ITDTMLCASVRKEGKDSCQGDSGGPLVCNGSLQGIISWGQDPCAVTRKPGVYT
----KVCKY------IDWIHEVMRNN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------MF----LLLMAFHILAVATAQSQG-NENKIIGGYTC
IQNSQPWQAALLAG--PGRSFLCGG-ALLSAQWV------ITAAHCARP-----------
ILRV---------------ALGKHNLRKWEATQQVLRVVRQVPHPSY--------SSRTH
DHDVMLLQLEKPARLGRAVRPIALAQSCASPG-TSCRVSGWGTTSSPIG-----------
-------EDTHSLE-CISMF--------LQCFFFWG---GGGEREMDA-QFLSKRAHEEV
PA------LGSDICLPLQG---------DSGGP---------LV-CEGR-LQGVV--SWG
ME-RCALPGYPGVYANLCRYQNWIQKTMQGK-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------LKTLMAALVLMAAV-RAEQEKVLHGGPC
EQMSHPYQAALYT----SGHLLCGG-VLIHPLWV------LTAAHCKKP-----------
NLRV---------------YLGKHNIHERESFQEESSVVRAVPHPRF--------NAATH
DQDIMLLRLRRPASLSDRIHPLTLETDCSANH-TTCHILGWGKTQ--DG-----------
-------DFPNTIQ-CAYVH--------LVPR-------EKCMQAYPD-QITRNMVCAGD
EK------YGKDSC---Q------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------MKLG--------L--------------LCA-LLSLLAG-HGWADTRAIGAEECR
PNSQ-PWQAGLFH-LTRLFCGATLISDRWLLTAAHCRK------P---------------
-----YLWVRLGEH-HLWKWEG--PEQLFRVTDFFPHPGFNKDLSANDHNDDIMLIRLPR
QARLSPAVQPLNLS-QTCVSPGMQCLISGWGAVSSPKALFPVTLQCANISILENKLCH--
WAYPGH-ISDSMLCAGLWEGGRGSCQGDSGGPLVCNGTLAGVVSGGAEPCSRPRRPAVYT
----SVCHY------LDWIQEIMEN-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------MGHPPP-GAARTWIILLLLLGAWA-------------------
--------------------------------------------GLSRAQGSKVLSGQEC
YPHSQPWQTALFQ----GERLICGG-VLVGAKWV------LTAAHCKKS-----------
KYTV---------------RLGDHSLESKDEPEQEIAVARSIQHPCYN-----SSNPEDH
NHDLMLIELRHRASLGSKVKPINLAPQCAYVG-QKCTISGWGTVTSPR------------
------------------------------------------------------------
------------------G---------DSGGP---------LV-CDEV-LQGIT--SWG
SD-PCGRPDRPGVYTNLCRYTEWVEKTMGNRD----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------LSLSLCIC---------------------------------------------
-----------QNL---TPV--PR--MF--LLLTALQIIALAMAQSQR-DENKIIGGYTC
IQNSQPWQAALLAG--PFRRFLCGG-ALLSRQWV------ITAAHCARP-----------
ILRI---------------ALGKHNLKNWEATQQVLRVVRQVPHPQY--------NSQTH
NNDLMLLQLERPIQLGRAVRPITIASSCARPG-TSCLVSGWGTTSSPIV-----------
-------RYPNSLQ-CVNIN--------ISSDQE-------CRQAYSQ-AITVGMVCAGV
PQ------GGKDSC---QG---------DSGGP---------LV-CKGQ-LQGLV--SWG
ME-HCALPGYPGVYTNLCKYRTWIQNTIWSK-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----MW---PLVAA-IAFLMVALSSGISQEYPKIL------NG-TNGTSGFLPGGYTCR
PHSQ-PWQAALLV-QGRLFCGGVLVHPKWVLTAAHCLKD---------------------
-----GYRVYLGKH-ALGRVE--AGEQVREVVRSIPHPQYQISPTHLNHDHDIMLLELQS
PVQPTNHIRVLPLSHNNCLPAGTCCRVSGWGTTTSPQVSYPQTLQCANIQLRSDEECR--
QVYPGK-ITPNMLCAGTKEGGKDSCEGDSGGPLICNGTLHGIISWGDFPCGQPNRPGVYT
----RVSQY------VLWIRETIRNHKTQEQKWTKGSQ----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------W----LG
LRWARGKTCSQMHLA---------------G--------------AEEPGACPSP-----
LQAMMILRL-------------------------IM-FALVT-G-HVRAETRIIKGYECS
PHSQ-PWQVALFQ-KTRLLCGATLIAPKWLLTAAHCRKP---------------------
-----RYVVHLGEH-NLQRRDG--CEQTLSATESFPHPDFNNSLPNKDHRNDIMLVKMTR
AAFITWAVRPLTLS-SHCVTPGTRCLVSGWGSTSSPQLQLPHTLRCANITIINHEECE--
KAYPGN-ITNTMVCASVLESGKDSCQGDSGGPLVCDGSLQGIISWGQDPCAVTRKPGVYT
----KVCKY------VDWIRKTMENN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----MW---PLAAV-TALLSVTLSGGISQESPKIL------NNTTNGTNGFLPGGYTCL
PHSQ-PWQAALVV-QGRLLCGGILVHPKWVLTAAHCLKE---------------------
-----GYRVYLGKH-ALGRVE--AGEQVREVARSIPHPQYQISPTHLNHDHDIMLLELKS
PVQLTSRACVLPLSHTDCLPPGTCCRVSGWGTTTSPQVNYPQTLQCANIQLRSDEECR--
QVYPGK-ITPNMLCAGSKEGGKDSCEGDSGGPLVCNGTLYGVISWGDFPCGQPNRPGVYT
----RVSRY------VSWIQETIRQQKTQQQKWTKGPQ----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------QF-------PL--------------TLD-LISISLG-QGWTDTRAIGAEECT
PNSQ-PWQAGLFF-LTRLFCGATLLNDQWLLTAAHCRK------P---------------
-----YLWVRLGEH-HLWKWEG--PEQLFRVTDFFPHPGFNSDLSAHDHNHDIMLIRLKR
PAKLGPAVQPLNIS-NNCVRPGTTCLISGWGATSSPEVEYPLSLQCANISVLDPRLCH--
KAYPGR-ITSNMVCAGLWEGGRGSCQGDSGGPLVCNGALAGVVSGGAEPCSKPKRPSVYT
----SVCQY------RKWISKTMREN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------MWLLLAFVLL-VS--AAQDGDKVLEGEEC
APHSQPWQVALFE----RGRFNCGA-FLISPHWV------LTAAHCQTR-----------
FMRV---------------RLGEHNLRKHDGPEQVRSVSRIIPHPGY--------EARTH
RHDIMLLRLLHPARLSSQVHPVALPTRCPFTG-EDCVVSGWGLLSANKPGD-SE------
-SHKSQVRLPDTLH-CANIS--------IISE-------ASCNKDYPG-RVLPTMVCAGV
EG------RGTDSC---EG---------DSGGP---------LV-CRGA-LQGIV--SWG
DV-PCDTTTKPGVYTKVCSYLKWIRENMKRN-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------MSLR---------------------------------------------
-----------VLGSG-TWPSAPKMF----LLLTALQVLAIDMTRSQE-DENKIIGGYTC
TRSSQPWQAALLAG--PGRRFLCGG-ALLSDQWV------ITAAHCGRP-----------
ILQV---------------ALGKHNLRRWEATQQVLRVVRQVTHPNY--------NSRTH
ENDLMLLRLQQPARIGRAVRPIEVAQACASSG-TSCRVSGWGTISSPIA-----------
-------RYPASLQ-CVNIN--------ISPDEV-------CQKAYSK-AITPGMVCAGV
PQ------GGKDSC---QG---------DSGGP---------LV-CRGQ-LQGLV--SWG
ME-RCALPGYPGVYTNLCKYRSWIEETMRHK-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------M----QR
LRWLRDWKSSGRGLT---------------A--------------AKEPGARSSP-----
LQAMRILQL-------------------------IL-LALAT-G-LVGGETRIIKGFECK
PHSQ-PWQAALFE-KTRLLCGATLIAPRWLLTAAHCLKP---------------------
-----RYIVHLGQH-NLQKEEG--CEQTRTATESFPHPGFNNSLPNKDHRNDIMLVKMAS
PVSITWAVRPLTLS-SRCVTAGTSCLISGWGSTSSPQLRLPHTLRCANITIIEHQKCE--
NAYPGN-ITDTMVCASVQEGGKDSCQGDSGGPLVCNQSLQGIISWGQDPCAITRKPGVYT
----KVCKY------VDWIQETMKNN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------MPRPRPGRAGLMWTVLLLLLLLLLA------------------
--SWP---------------------------------------GRTEAQVSKVLQGSEC
EPHSQPWQTALFQ----GERLLCGG-VLVGT-----------------R-----------
KYTV---------------RLGDHSLQSKDEPEQEISVAQSIQHPCYN-----SSNSEDR
NHDLMLIRLRKQASLGPKVQPIDLAKHCAKVG-QKCTISGWGTVTSPRE-----------
-------NFPDTLN-CAEVE--------IFSL-------RKCEEAYPG-QVTDGMVCAGN
S-------NGADTC---QG---------DSGGP---------LV-CDGV-LQGIT--SWG
SD-PCGRPKKPGVYTSICHYRKWIKKTMGNRG----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------MKLG-------LA--------------L-T-LLSLLAG-HGLADTRAIGAKECP
RHSQ-PWQAGLFY-LTRPFCGATLISDRWLLTAAHCLK------S---------------
-----HLWVRLGEH-HLWQWEG--PEKLFLATDFFPHPGFNQDLTANDHNDDIMLIRLPR
RVPLSDAVQPLNLS-HDCVTPGTQCLISGWGAVSSPKAQYPLTLQCANISILSNSLCH--
WAYPGH-ISEKMLCAGLWEGGRGSCQGDSGGPLVCNGTLAGVVSGGSEPCSRPRRPAVYT
----SVCHY------VDWVEKTMKEN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------MKSG--------F--------------VCA-LLSLLAG-HSWADTRTIGGKECA
PNSQ-PWQAGLFH-LPRLFCGATLISDHWLLTAAHCRK------P---------------
-----FLWVRLGEH-HLWKWEG--PEQLFRVTDFFPHPGFNKDLSANDHNDDIMLIRLPR
EAQLGPAVQPLNLS-QNCVIPGTECLISGWGAVSSPKARYPLTLQCANISILEPTLCH--
RAYPGH-ISDSMLCAGLWEGGRGSCQGDSGGPLVCNGTLAGVVSGGAEPCSRPGRPAVYT
----NTCYY------LDWIQETMEKT----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------M---------QLLL-TSSFLL-IAAAQ-VSDKGLESEEC
APHSQPWQVALYE----RGRFNCGA-SLISPHWV------LTAAHCRTS-----------
FMRA---------------HLGEHNLHKREGPEQLRLVSLAIPHPRY--------EARSH
RHDVMLLRLARPARLTPQVRPVALPVHCPQPG-EPCVVSGWGLVSGDKPGT-TG------
-SPESQVTVPDTLH-CANIS--------VISR-------AACDKDYPG-RLMDTMVCAAA
EG------GGTDSC---EG---------DSGGP---------LI-CGGA-LQGIV--SWG
DV-PCDTTAKAGVYTKVCRYLQWIRETIRRN-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------MWL-LTLSFLLASAAAQ-DGDK-LEGDEC
APHSQPWQVALYE----RGRFNCGA-SLISPHWV------LSAAHCQSR-----------
FMRV---------------RLGEHNLRKRDGPEQLRTASRVIPHPRY--------EARSH
RHDIMLLRLVQPARLTPQVRPAVLPTRCPHPG-EACVVSGWGLVSHNEPGT-TG------
-SPQSQVSLPDTLH-CANIS--------IISD-------TSCDKSYPG-RLTNTMVCAGA
EG------RGAESC---E------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----MW---PLVAA-VACLTVALSRGISRDYPKIL------NG-TNGTHGFLPGGYTCL
PHSQ-PWQAALLV-HGRLLCGGVLVHPKWILTAAHCRKD---------------------
-----GYTVHLGKH-ALGRVE--NGEQAMEVVRSIPHPEYQVSPTHLNHDHDIMLLELKS
PVQLSSHIRPLPLSPEDCLPTGTCCRVSGWGTTTSPQVNYPKTLQCANIELRSDEECR--
QVYPGK-ITANMLCAGTKEGGKDSCEGDSGGPLVCNGKLYGIISWGDFPCGQPNRPGVYT
----RVSKY------LHWIWHTIKNTPKQ--RWTKSTQ----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------MWLLLTLSFLLASSATQ-DGDKSLEGDEC
APHSQPWQVALYE----RGRFNCGA-SLISPHWV------LSAAHCQTR-----------
FMRV---------------RLGEHNLRKRDGPEQLRTASRVIPHPRY--------EARSH
RHDIMLLRLVQPARLTPQVRPVVLPTRCPHPG-EACVVSGWGLVSHMEPGT-TR------
-SPQSQVSLPDTLH-CANIS--------IISD-------TSCDKSYPG-RLTNTMVCAGA
EG------RGAESC---EG---------DSGGP---------LV-CGGI-LQGIV--SWG
DV-PCDNTTKPGVYTKVCHYLKWIRETMKRN-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---MRILQL-------------------------IM-LALAT-G-LVGGETRIIKGFECK
PHSQ-PWQAALFE-KTRLLCGATLIAPSWLLTAAHCRKPWVSLTSPNHVSPDLS-SSNYC
LSHLSRYIVHLGEH-NLQTQDG--CEQTRTATESFPHPGFNNSLPNKDHRNDIMLVKMAS
PASITWAVRPLTLS-SRCVTAGTSCLISGWGSTSSPQLRLPHSLRCANITIIEHQKCE--
NAYPNN-ITDTMVCASVQEGGKDSCQGDSGGPLVCNHSLQGIISWGQDPCAITRKPGVYT
----KVCKY------VDWIQETMKNN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------MKKLMVVLSLIAAAWAEEQNKLVHGGPC
DKTSHPYQAALYA----SGHLLCGG-VLIHPLWV------LTAAHCKKP-----------
NLQV---------------FLGKHNLRQRESSQEQSSVVRAVIHPGY--------DAATH
DQDIMLLRLARPAKLSELIQPLPLERDCSANT-TSCHILGWGKTA--DG-----------
-------DFPDTIQ-CAYIH--------LVPR-------EECERAYPG-QITQNMLCAGD
EK------YGKDSC---QG---------DSGGP---------LV-CGDH-LRGLV--SWG
NI-PCGSKEKPGVYTNVCRYTNWIQKTIQAK-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------MWLLLTLSFLLASSAAQ-DGDKLLEGDEC
TPHSQPWQVALYE----RGRFNCGA-SLISPHWV------LSAAHCQTR-----------
FMRV---------------RLGEHNLRKRDGPEQLRTASRVIPHPRY--------EARSH
RHDIMLLRLVQPARLTPQVRPVVLPTRCPHPG-EACVVSGWGLVSHIEPGT-TR------
-SPQSQVSLPDTLH-CANIS--------IISD-------TSCDKSYPG-RLTNTMVCAGA
EG------RGAESC---EG---------DSGGP---------LV-CGGV-LQGIV--SWG
DV-PCDNTTKPGVYTKVCHYLKWIRETMKRN-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------MF----LLLSALQVLAVAIAQNPG-DDNKVIGGYSC
IRNSQPWQVALLAG--AGRRFLCGG-VLLLDQWV------LTAAHCARP-----------
ILYV---------------SLGKHNLRRWEATQQVLHVQRQVPHPSY--------NARTH
DSDLMLLRLRQRARIGRAVRPIGLARSCASPG-TSCLVSGWGTTSSPIA-----------
-------RYPSALQ-CVNIN--------IFSDQA-------CQQAYPN-AITEGMVCAGV
PQ------GGRDSC---QG---------DSGGP---------LV-CGGQ-LQGLV--SWG
ME-RCAMAGYPGVYTNLCKYRSWIQRTMQGQ-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------MRLG--------L--------------VCA-LLSLLTG-EAPAVHLAHSGSY-R
DDGG-P----------GTVCGLWSTQAWWTP----SLTSEACPNR---------------
-----YLWVRLGEH-HLWRWEG--PEQLFRVTDFFPHPGFNKDLRAHDHNDDIMLIRLPR
KAHLGPAVQPLNLS-QTCVSPGTQCLISGWGAVSSPKVQYPLTLQCANISILEHKLCH--
RAYPGH-ISDSMLCAGLWEGGRGSCQGDSGGPLVCEGTLAGVVSGGAEPCSRPRRPAVYT
----SVCHY------VDWIRKTMEDN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------K----RQ
LRWPRDWTSLGPGHT---------------A--------------AKEPGACSSP-----
LQAMTILRL-------------------------IT-LALVT-G-HVRGETRIIKGYECK
PHSQ-PWQAALFQ-KTRLLCGATLIAPSWLLTAAHCRKP---------------------
-----HYIVHLGEH-NLQRRDG--CEQTRTATESFPHPGFNNSLPNKDHRNDIMLVKMAA
PALITWAVRPLTLS-SRCVTAGTRCLISGWGTTSSPQLHLPHTLRCAKISIIEHRECE--
DAYPGN-ITDTMVCASVKEEGKDSCQGDSGGPLVCNDSLQGIISWGQDPCAVTKKPGVYT
----KVCKY------VDWIQETMKNN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------MGHPP-AAAVWIWTFL----LLVLE------------------
--AWT---------------------------------------GHLRAQESKVLGGQEC
EAHSQPWQTALFQ----GVRLLCGG-VLIDDNWV------LTAAHCKKQ-----------
KYTV---------------RLGEHSLKKKDSSEQEMAVAQSIPHPCYN-----SS-SEDH
SHDLMLIRLRGQASLGPQVKPINLADHCPQAG-QKCTISGWGTVTSPRE-----------
-------NFPDTLN-CAEVQ--------IFPL-------KKCKDVYPG-EVTDGMICAGD
S-------NGADSC---QG---------DSGGP---------LV-CGGV-LQGIT--SWG
SD-PCGRPERPGIYTNICRYLDWIKKTIGSRG----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------MGRPPP-CAIQKWIFLFLLMGTWA-------------------
--------------------------------------------GLTKAQGSKVLEGQEC
KPHSQPWQTALFQ----GPRLVCGG-VLVGDKWI------LTAAHCKKQ-----------
KYSV---------------RLGDHSLQSRDKPEQEIQVAQSIQHPCYN-----SSNPEDH
SHDVMLIRMRHSANIGDKVKSIKLAEECPKVG-QKCTISGWGTVTSPRE-----------
-------NFPDTLN-CAEVE--------IFSQ-------SKCEKAYPG-KVTEGMVCAGS
S-------NGADTC---QG---------DSGGP---------LV-CNGV-LQGIT--SWG
SD-PCGKPEKPGVYTNICYYSDWIHKTMNNRD----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----MKLGF--------GF--------------TWV-LLSLLAG-HSWADTRAIGAKECP
RNSQ-PWQAGLFF-LTRLFCGATLISDRWLLTAAHCRK------P---------------
-----YLWVRLGEH-HLWQWEG--PEQLFRVTDFFPHPGFNSDLSANDHNHDIMLIRLPR
RVSLGPVVQPLNIS-RTCVSPGTKCLISGWGAVSSPKVRFPLTLQCANISILEPIFCH--
LAYPGH-ISDNMICAGRWEGGLGSCQGDSGGPLVCDGALAGVVSGGGEPCSRPRRPTVYT
----RICHY------HDWIRKTMKENSP--------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------MWLLLTFSFLLTSTAAQ-HGGKLLKGEEC
VPHSQPWQVALYE----RGRFNCGA-SLISPHWV------LSAAHCWTG-----------
SMRV---------------RLGEHNLRKRDGPEQVRAVSRVIPHPQY--------EVRSH
RHDIMLLQLAQPASLTPQVHPVALPTHCPHSG-EACVVSGWGLVSNNETRT-TG------
-RPKSQVSLPDTLH-CANIS--------IISD-------TSCDKDYPG-HLMNTMVCAGA
EG------GGTDSC---EG---------DSGGP---------LV-CRGV-LQGIV--SWG
DV-PCDTTTKPGVYTKVCSYLEWIREVMERN-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------MSRVRRT-CRLEWRGGGG---GWEEG--P------------GA
GVGL------RQRLRS-IWLPFSGMG------TKTLV-VLILMAAAWAEEQNKVLHGGPC
EQTSHPYQAALYT----SDHLLCGG-VLIHPLWV------LTAAHCKKP-----------
NLQV---------------YLGKHNLQQRESFQEQSSVVRAVVHPGY--------NAATH
DQDIMLLRLSHPAKFSERIQPLPLEQDCSANH-TSCHILGWGKTA--DG-----------
-------GFPNTIQ-CAYIH--------LVSH-------EECERAYPS-QITRNMVCAGD
EK------YGKDSC---QG---------DSGGP---------LV-CGDR-LRGLV--SWG
NV-PCGSKEKPGVYTDVCRYGHWIRKTIQAN-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------MWLLLAFVLLVSA--AQQDRDKVLEGEEC
VPHSQPWQVALFE----RGRFNCGA-FLISPRWV------LTAAHCQTR-----------
FMRV---------------RLGEHNLRKFDGPEQLRSVSRIIPHPGY--------EARTH
RHDIMLLRLFQPARLTAYVRPVALPTRCPLIG-EDCVVSGWGLLSDNNPGA-TG------
-SQKSQVRLPDTLH-CANIS--------IISE-------ASCNKDYPG-RVLPTMVCAGV
EG------GGTDSC---EG---------DSGGP---------LV-CGGA-LQGIV--SWG
DV-PCDTTTKPGVYTKVCSYMEWIWENVRRG-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------MWLLLTFSFLLTST-AQ-EGDKLLKGEEC
APHSQPWQVALYE----RGRFNCGA-SLISPHWV------LSAAHCQTR-----------
SMRV---------------RLGEHNLRKWDGPEQLWAVSRVIPHPGY--------EARSH
RHDVMLLRLARPARLTTQVRPVMLPTRCPSPS-EACVVSGWGLVTNNEPGT-TG------
-SPESQVSLPDTLH-CANIS--------IISD-------TSCNKDYPG-HLMSTMVCAGA
EG------GGTDSC---EG---------DSGGP---------LV-CSGV-LQGIV--SWG
DV-PCDTTKKPGVYTKVCHYLEWIREIMKRN-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------MGRPPP-CATQTWILLFLLMGAWA-------------------
--------------------------------------------GLTRAQGSKVLEGQEC
EPHSQPWQTALFQ----GPRLVCGG-VLVGDKWV------LTAAHCKKQ-----------
KYSV---------------RLGDHSLQNRDAPEQEIQVAQSIQHPCYN-----NSNPEDH
SHDVMLVRMRRSANLGSKVKPIKLANLCPKVG-QKCVISGWGTVTSPRE-----------
-------NFPDTLN-CAEVE--------IFSQ-------NKCEKAYPG-KVTEGMVCAGS
S-------NGADTC---QG---------DSGGP---------LV-CNGV-LQGIT--SWG
SD-PCGKPEKPGVYTRVCRYVDWIKKTMNYRD----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------MGRPPP-RAGLKWMFLLLLGKIWAACGHPGPL--TKLYAENLP
CVHSTPQW-PSQPW---------HCP------RGWQSNPLPPAAGHSRAQENKVLGGQEC
QPHSQPWQAALFQ----GEQLLCGG-VLIGRNWV------VTAAHCKKP-----------
KYTV---------------RLGDHSLQKKDGPEQEIAVVQSIPHPCYN-----SSNVDDH
NHDLMLLQLRSQASLGSKVKPISLADHCIHPG-QKCTISGWGTTTSPQE-----------
-------NFPDTLN-CAEVK--------IFPQ-------KKCEDAYPE-QITDAMICAGN
N-------NGADTC---QG---------DSGGP---------LV-CDGA-LQGIT--SWG
SD-PCGRPNRPGVYTNICRYLDWIKKTIGSKG----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------MKLG--------L--------------LCA-LLSLLAG-HGWADTRAIGAEECR
PNSQ-PWQAGLFH-LTRLFCGATLISDRWLLTAAHCRK------P---------------
-----YLWVRLGEH-HLWKWEG--PEQLFRVTDFFPHPGFNKDLSANDHNDDIMLIRLPR
QARLSPAVQPLNLS-QTCVSPGMQCLISGWGAVSSPKALFPVTLQCANISILENKLCH--
WAYPGH-ISDSMLCAGLWEGGRGSCQGDSGGPLVCNGTLAGVVSGGAEPCSRPRRPAVYT
----SVCHY------LDWIQEIMEN-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------RK------SGIFFSAAIHVMDYPFDTGERIIGGTEC
LAHSQPWQVFLYT----SKLSRCGG-ALIDTFWV------LTAAHCWRR----------G
-LTV---------------HIGEHDLRKHDDGEQSSKVAKLIRHPEY--------EPNTL
KNDIMLVRLDTPAILGEYVKTVPVAKECIPVG-AKCVVSGWGTTTFPAV-----------
-------NYAYRLQ-CLEIS--------ILSK-------NICNATYGS-LFNDNHICAGA
IE------GGKDSC---RG---------DSGSS---------LV-CNGT-LHGVV--SWG
PK-NCGEKNKPAAYTEICKFSKWIEETMQIN-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------MGRPRP-RAAKTWMFLLLLGGAWA-------------------
--------------------------------------------GHSRAQEDKVLGGHEC
QPHSQPWQAALFQ----GQQLLCGG-VLVGGNWV------LTAAHCKKP-----------
KYTV---------------RLGDHSLQNKDGPEQEIPVVQSIPHPCYN-----SSDMEDH
NHDLMLLQLRDQASLGSKVKPISLADHCTQPG-QKCTVSGWGTVTSPRE-----------
-------NFPDTLN-CAEVK--------IFPQ-------KKCEDAYPG-QITDGMVCAGS
S-------KGADTC---QG---------DSGGP---------LV-CDGA-LQGIT--SWG
SD-PCGRSDKPGVYTNICRYLDWIKKIVGSKG----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------MWLLLTFSILLTSAGAQ-DGEKVLRDEEC
APHSQPWQVALFE----RGRFNCGA-SLISPQWV------VSAAHCQSR-----------
FMRM---------------LLGEHNLRKRDGPEQLQAVSRVIPHPSH--------EARSH
RQDVMLLKLARPARLTRQVRLVALPRRCPRAG-EACVVSGWGLVSDDEPRN-RG------
-SPEPQVSLPDTLH-CANIS--------IIST-------DSCNKEYPG-RLMNTMVCAGV
EG------GGTNSC---EG---------DSGGP---------LV-CGGV-LQGIV--SWG
DV-PCDTTTKPGVYTKVCSYLEWIRETMRRN-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------MRLG--------F--------------VWA-LLSLLAG-HGWADTRTIGAEECR
PNSQ-PWQAGLFY-LTHLFCGATLISDRWLLTAAHCRK------R---------------
-----HLWVRLGEH-HLWKWEG--PEQLFRATDFFPHPGFNQDLSAQDHNDDIMLIRLPR
KANLGPTVQPLNLS-QTCFSPGTQCLISGWGAVSSPKVQYPLTLQCANISILEPKLCH--
QAYPGH-ISDSMLCAGLWEGGRGSCQGDSGGPLVCNGTLAGVVSGGSEPCSRPQRPAVYT
----SVCRY------LDWIRKTMEDN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------GGGWESFCLPASPTLAHRCLLLAMAQNQG-N-EKIIGGYTC
TQGSQPWQAALLQG--PQRRFLCGG-SLLSDQWV------ITAAHCARP-----------
ILRV---------------ALGKHNLKIPEATQQVLRVVRKVPHPRY--------NSRTN
DNDLMLLQLERPARLGPRVRPISVASSCARVG-SSCLVSGWGTISSPVA-----------
-------RYPNSLQ-CVNIN--------ISSDQE-------CRRAYSG-AITPGMVCAGV
PQ------GGKDSC---QG---------DSGGP---------LV-CGGQ-LQGLV--SWG
ME-RCAQPGYPGVYTNLCKYHTWIQGTIRRR-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----MW---PLAAA-VACLTLALSGGISQEYPKIL------NG-TNGTSGFLPGGYTCL
PHSQ-PWQAALLV-RRRLLCGGVLVHPKWVLTAAHCMKA---------------------
-----GYTVHLGKH-VLGRVE--TREQVREVARSVPHPEYQVSPTHLNHDNDIMLLELAS
PVQLTGHIRTLPLSRSDCLPPGTCCRVSGWGTTTSPQVSYPKTLQCANIPLRSDEECR--
RVYPGK-ITANMLCAGSKEGGKDSCEGDSGGPLVCNGTLHGIISWGDFPCGQPNRPGVYT
----RVSKY------VSWIHETIKKHKTQEQKWTKGAQ----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------MEVVRSIPHPEYQVSPTHLNHDHDIMLLELKS
PVQLSSHIRALPLSPDDCLPTGTCCRVSGWGTTTSPQVNYPKTLQCANIELRSDEECR--
QVYPGK-ITANMLCAGTK------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------MDL------KKTLTVALTLVAAAWAEEQNKLVHGGPC
EKTSHPYQAALYT----SGHLLCGG-VLIHPQWV------LTAAHCKKP-----------
KLQV---------------YLGKHNLRQRENSQEQSHVVRAVAHPGY--------NAATH
DQDIMLLRLEYPVKLSEWIQPLPLEKNCLANH-TSCHILGWGKTA--DG-----------
-------DFPDTIQ-CAYIH--------LVPP-------EECERAYPG-QITPNMVCAGD
EK------YGKDSC---QG---------DSGGP---------LV-CGNR-LRGLV--SWG
NV-PCGSKEKPGVYTDVCRYTHWIRKTIQAK-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------RIIKGYECS
PHSQ-PWQVALFQ-KTRLLCGATLIAPKWLLTAAHCRKP---------------------
-----RYIVHLGEH-NLQRQDG--SEQTRTATESFPHPEFNYSLPNKDHRNDIMLVKMAS
PAMITWAVRPLTLS-SRCVTPGTQCLISGWGTTSSPQLHLPHTLRCANITIIEHKECE--
KAYPGD-ITDTMVCASVQEEGKDSCQGDSGGPLVCNGSLQGIISWGQDPCAVSRKPGVYT
----KVCKY------VDWIQETMQNN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
FMRA---------------RLGEHNLRKHDGPEQLLPISRIIPHPAY--------EARSH
LHDVMLLRLARPAHQTRQVRPVRLPTRCPYPG-EACLVSGWGLVSDNRPET-TG------
-RPGPQVSLPDTLH-CANIS--------IIST-------AACNKEYPG-RLRDTMVCAGV
AG------GGTDSC---E------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------MF----LLLTVLQVMAVAVVQSQE-DDNKIIGGYPC
AQYSQPWQVALLAG--PGRRFLCGG-ALLSDQWV------ITAAHCARP-----------
TLHV---------------ALGKHNLRRWEATQQVIRVVRQVPHPQY--------QPRAH
NNDLMLLRLQRKVRMGRAVRPIILTSSCASPG-TACRVSGWGTISSPIV-----------
-------RYPNRLQ-CVNIN--------IMPEQV-------CRNAYPG-AITEGMVCAGV
PQ------GGKDSC---QG---------DSGGP---------LV-CGGQ-LQGLV--SWG
ME-HCARPGYPGVYSNLCKYHTWIRRTIQAW-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------M----QR
LRWLQDWKSSGRGLT---------------A--------------AKEPGARSSP-----
LQAMRILQL-------------------------IL-LALAT-G-LVGGETRIIKGFECK
PHSQ-PWQAALFE-KTRLLCGATLIAPRWLLTAAHCRKP---------------------
-----RYIVHLGQH-NLQKEEG--CEQTQTATESFPHPGFNDSLPNKDHRNDIMLVKMAS
PVSITWAVRPLTLS-SRCVTAGTSCLISGWGSTSSPQLRLPHTLRCANITIIEHQKCE--
NAYPGN-ITDTMVCASVREGGKDSCQGDSGGPLVCNESLQGIISWGQDPCAITRKPGVYT
----KVCKY------VDWIQETMKNN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------CAEEQDKLVHGGPC
ERTSHPYQAALYT----SGHLLCGG-VLIHPLWV------LTAAHCRKP-----------
KLQV---------------YLGKHNLRQTESSQEKTPVVRTVTHPGY--------DAATH
DQDIMLLRLARPANLSESIQPLPLERDCSAHH-SSCHILGWGKTA--HG-----------
-------DFPDTIQ-CAYIH--------LVPR-------EECERAYPG-QITQSMLCAGD
EK------YGTDSC---Q------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------T
EETRPSYLFFLFL----SQNSLPTNILQILPLLI------LP----PSE-----------
NLQV---------------FLGKHNLQQRESSQEQSSVVRAVIHPGY--------DASTH
DQDIMLLRLAHPAKLSELIQPLPLERDCSANY-TSCHILGWGKTA--DG-----------
-------DFPDTIQ-CAYIH--------LVSR-------EECERAYPG-QITQNMLCAGD
EK------YGKDSC---QG---------DSGGP---------LV-CGDR-LRGLV--SWG
NI-PCGSKEKPGVYTNVCRYTNWIRKTIQAK-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------MKLG--------L--------------LCA-LLSLLAG-HGWANTRAIGAEECR
PNSQ-PWQAGLFH-LTRLFCGATLISDRWLLTAAHCRK------P---------------
-----YLWVRLGEH-HLWKWEG--PEQLFRVTDFFPHPGFNKDLSANDHNDDIMLIRLPR
QAHLSPAVQPLNLS-QTCVSPGTQCLISGWGAVSSPKALFPVTLQCANISILENKLCH--
WAYPGH-ISDSMLCAGLWEGGRGSCQGDSGGPLVCNGTLAGVVSGGAEPCSRPRRPAVYT
----SVCHY------LDWIQEIMEN-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------MGCPPP-CATQKWIFVSLLMGTWA-------------------
--------------------------------------------GLTRAQGSKVLEGREC
KPHSQPWQTALFQ----GPRLVCGG-VLVGDKWV------LTAAHCKKQ-----------
KYSV---------------RLGDHSLQSRDRPEQEIQVVQSIQHPCYN-----SSNPEDH
SHDIMLIRMRRSANLGDKVKSIKLANECPKVG-QKCTISGWGTVTSPRE-----------
-------NFPDTLN-CAEVE--------IYSQ-------NKCEKAYPG-KVTEGMVCAGS
S-------NGADTC---QG---------DSGGP---------LV-CNGV-LQGIT--SWG
SD-PCGKPEKPGVYTNIYHYRDWIHKTMNNRD----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------SQDNDMVLGGEEC
RPHSQPWQAALFE----GSRFNCGA-SLISNQWL------LTAAHCITG-------FSGS
KMQV---------------RLGEHNLRVREGVEQLRGVSYAIPHPRY--------KSHGH
HDDIMLLRLTRPARLSDSVRPVPLPTRCPRQG-EQCVVSGWGLVAESKTGAG--------
----RRVKLPDTLH-CANIS--------IIST-------ASCDKDYRG-QVTDTMVCAGV
AG------GGTDSC---EG---------DSGGP---------LV-CGGM-LQGIV--SWG
DV-PCDTTAKPGVYTKVCKYLGWIHDVMK-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------ARDGDKVLEGEEC
PPHSQPWQVALYE----RGRFNCGA-SLISPRWV------LSAAHCQTR-----------
FMSV---------------HLGEHNLRKHEGPEQLRAVLRTIPHPGY--------EPRSH
LHDIMLLRLARPVNLTPQVRPLALPTRCPHPG-EACVVSGWGLVSDNESGT-TG------
-SPTSQVSLPDTLH-CANIS--------IIPD-------TSCNKDYPG-RLRDTMVCAGV
EG------GGTDSC---EG---------DSGGP---------LV-CGGV-LQGVV--SWG
DV-PCDTTTKPGVYSKVCCYLDWIRETMRRN-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------MCLLLTFSFLLASAVAQDDSDKVRRDEEC
VPHSQPWQVALFE----HGRFNCGA-SLISPQWVL------SAAHCQTR-----------
FLRV---------------RLGEHNLRKRDGPEQLRTVSRIIPHPRY--------KALNH
RHDLMLLRLTRPVRVTAEVRPIPLPARCPQAG-EACVVSGWGLVANKEPGA-TG------
-SPESQVRLPDRLH-CANIS--------IIST-------ASCNKDYAG-RLMDTMVCAGV
EG------GGINSC---EG---------DSGGP---------LV-CGGV-LQGIV--SWG
DV-PCDTTTKPGVYTKVCSYLEWIKETMKRS-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------VSLR---------------------------------------------
-----------VLVSV-TRPPAPRMF----LLLTALQILATAMTQSQE-DENKIIGGYTC
VQNSQPWQAALMAG--PWRHFLCGG-ALLSDQWV------ITAAHCARP-----------
ILRV---------------YLGKHNLRRWEATQQLLRVTRQVTHPYY--------NSRTH
DNDLMLLRLEKPVTLGRAVRPISLPKDCPSPG-TPCIASGWGTISSPIA-----------
-------RYPHSLQ-CVNIN--------ITPDQV-------CRRAYPG-AITPGMVCAGV
PQ------GGKDSC---QG---------DSGGP---------LV-CRGE-LQGLV--SWG
ME-RCALPGYPGVYTNLCKYQDWIKQTMRSQ-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----MW---PLALV-IASLTLGLSGGVSQESSKVL------N--TNGTSGFLPGGYTCF
PHSQ-PWQAALLV-QGRLLCGGVLVHPKWVLTAAHCLKE---------------------
-----GLKVYLGKH-ALGRVE--AGEQVREVVHSIPHPEYRRSPTHLNHDHDIMLLELQS
PVQLTGYIQTLPLSHNNRLTPGTTCRVSGWGTTTSPQVNYPKTLQCANIQLRSDEECR--
QVYPGK-ITDNMLCAGTKEGGKDSCEGDSGGPLVCNRTLYGIVSWGDFPCGQPDRPGVYT
----RVSRY------VLWIRETIRKYETQQQKWLKGPQ----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------MKLG--------L--------------LCA-LLSLLAG-HGWADTRAIGAEECR
PNSQ-PWQAGLFH-LTRLFCGATLISDRWLLTAAHCRK------P---------------
-----YLWVRLGEH-HLWKWEG--PEQLFRATDFFPHPGFNKDLSANDHNDDIMLIRLPR
QARLSPAVQPLNLS-QTCVSPGTQCLISGWGAVSSPKALFPVTLQCANISILENKLCH--
WAYPGH-ISDSMLCAGLWEGGRGSCQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
----XXXXX------XXXXXXXXES-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----TMW---TLAAV-VASLTVALSKGISREHPKIL------NG-TDGANGFLPGGYTCL
PHSQ-PWQAALLV-QGRLLCGGVLVHPKWVLTAAHCLKD---------------------
-----EYRVYLGKH-ALGRVE--TGEQVREVARSIPHPQYRISPTHMNHDHDIMLLELQS
PVQLTGYVRVLPLSHEDCFPPGTCCRVSGWGTTTSPQVSYPQTLQCANIQLRSDEECR--
QVYPGK-ITRNMLCAGTKEGGKDSCEGDSGGPLVCNGTLHGIISWGDFPCGQPDRPGVYT
----RVSQY------VPWIHETIRKHKTEEQKWTRDPQ----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------M----QR
LRWLQDWKSSGRGLT---------------A--------------AKEPGARSSP-----
LQAMRILQL-------------------------IL-LALAT-G-LVGGETRIIKGFECK
PHSQ-PWQAALFE-KTRLLCGATLIAPRWLLTAAHCRKP---------------------
-----RYIVHLGQH-NLQKEEG--CEQTQTATESFPHPGFNDSLPNKDHRNDIMLVKMAS
PVSITWAVRPLTLS-SRCVTAGTSCLISGWGSTSSPQLRLPHTLRCANITIIEHQKCE--
NAYPGN-ITDTMVCASVREGGKDSCQGDSGGPLVCNESLQGIISWGQDPCAITRKPGVYT
----KVCKY------VDWIQETMKNN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----MLIRLRKEASLGSKVKPIDLPDRCAKVG-QKCTISGWGTVTSPRE-----------
-------NFPDTLN-CAEVE--------IFSQ-------KKCEEAYPG-QVTDGMVCAGN
S-------DGADTC---QG---------DSGGP---------LV-CGGV-LQGIT--SWG
SD-PCGRPKKPGVYTNICRYLDWIKKTMGNRC----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------PSP-----
LQAMMTLQL-------------------------IM-FALVT-G-HVGGETRIIKGYECP
PHSQ-PWQAALFQ-KTRLLCGATLIAPRWLLTAAHCRKP---------------------
-----RYVVRLGAH-SLQRQEG--CEQTRTATESFPHPDFNNSLPNRDHRNDIMLVKMRT
PAHLTWAVRPLTVS-PCCVAAGANCLISGWGTMSSPQLHLPRNLRCANVTIIKHGECE--
DAYPGN-ITDTMVCASVRKEGKDSCQGDSGGPLVCNGSLQGIISWGQDPCAVSKKPGVYT
----KVCKY------VDWIQKTMENN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------VSIA
MAAMQLLVLA------------------------VLVAGAAAGCDSGGVKERLFIGYPCR
NGSR-PYQAALLK-NGTTYCAGSLIHPKWVLTAAHCSRN---------------------
---ISSVQVHLGDY-NLQVKE--GTEQIRRIRSYFMHPKYNLR----RLDYDFMLLELDK
PVRLNNFVKTIRLA-TRCPAPGTRCRVSGWGITNFPKNHTLGNLQCADLRTISRTRCL--
EPYPGR-ITENMLCAGMERGSIRSCQGDSGGPLVCKGRLQGLVSWGGPICVLPEKPGVYA
----KVCKA------VRWVRDTIRRRC---------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----MW---PLAAA-ISFLMVAWSGGISREYPKIL------NG-TNGTNGFLPGGYTCI
PHSQ-PWQAALKV-QGRLLCGGVLVHPKWVLTAAHCLKDRR-------------------
-----GYRVYLGKH-VLARVE--AGEQVREVARAIPHPRYQSSPTHLNHDHDIMLLELKS
SVQLTRHIQTLPLSHHHCLPPGTCCRVSGWGTTTSPQVTFPQTLQCANIELRSDEECR--
QVYPGK-ITPNMLCAGTKEGGKDSCEGDSGGPLVCNGTLHGIISWGDFPCGQPNRPGVYT
----RVSQY------VPWIQETIQKRKTCKQEWTKGPQ----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------MSLR---------------------------------------------
-----------VLGSG-TWPSAPKMF----LLLTALQVLAIDMTRSQE-DENKIIGGYTC
TRSSQPWQAALLAG--PGRRFLCGG-ALLSDQWV------VTAAHCGRP-----------
ILQV---------------ALGKHNLRRWEATQQVLRVVRQVTHPDY--------NSRTH
ENDLMLLRLQQPARIGRAVRPIEVAQACASSG-TSCRVSGWGTISSPIA-----------
-------RYPASLK-CVNIN--------ISPDEV-------CQRAYSK-AITPGMVCAGV
PQ------GGKDSC---QG---------DSGGP---------LV-CRGQ-LQGLV--SWG
ME-RCALPGYPGVYTNLCKYRSWIEETMRHK-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---MRILQL-------------------------IM-LALAT-G-LVGGETRIIKGFECK
PHSQ-PWQAALFE-KTRLLCGATLIAPSWLLTAAHCRKPWVSLTSPNHVSPDLS-SSNYC
LSHLSRYIVHLGEH-NLQKQDG--CEQTRTATESFPHPGFNNSLPNKDHRNDIMLVKMAS
PAFITWAVRPLTLS-SRCVTAGTSCLISGWGSTSSPQLRLPHSLRCANITIIEHQKCE--
NAYPSN-ITDTMVCASVQEGGKDSCQGDSGGPLVCNHSLQGIISWGQDPCAITRKPGVYT
----KVCKY------VDWIQETMKNN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------MKKLIAALLLVAAAWAEEQDKVVHGGPC
E-TSHPYQAALYT----SGHLLCGG-VLIHPLWV------LTAAHCKKP-----------
NLQV---------------YLGKHNLRQRESSQEQSSVVRSVTHPGY--------DAATH
DQDIMLLRLAHRAKLSEHIQPLLLEKDCSANH-TSCHILGWGKTA--DG-----------
-------DFPDTIQ-CAYIH--------LVPR-------EECERAYPG-QITQNMVCAGD
EK------HGKDSC---QG---------DSGGP---------LV-CGDR-LRGLV--SWG
NV-PCGSKEKPGVYTNVCRYNNWIRKTIQAN-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----NLQVLLGAH-NRTKPT--GHKQYTYAAKICPHEEFDWS----TYNNDIMLLKLAS
QADINTRVAPIPLA-SYLVADNTECLASGWGSTTSPQETYPDNLKCVNITTVSNSVCQ--
ACYPSDIITDNMLCAGNMAGGKDTCVGDSGGPLVCNGELHGITSWGDLVCGSPNKPGIFA
----KVFNY------LNWISDIIQNEAPCRVVG---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------MSLR---------------------------------------------
-----------VLGSG-TWPSAPKMF----LLLTALQVLAIAMTQSQE-DENKIIGGYTC
TQSSQPWQAALLAG--PRRRFLCGG-ALLSDQWV------ITAAHCGRP-----------
ILQV---------------ALGKHNLRRWEATQQVLRVVRQVTHPNY--------NSRTH
DNDLMLLRLQQPTRIGRAVRPIEVTQACASPG-TSCRVSGWGTISSPIA-----------
-------RYPASLQ-CVNIN--------ISPDEV-------CQKAYPR-TITPGMVCAGV
PQ------GGKDSC---QG---------DSGGP---------LV-CRGQ-LQGLV--SWG
ME-RCALPGYPGVYTNLCKYRSWIEETMRDK-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------IIGGEECV
PHSQ-PWQVALYY-FSDFICGGALINQWWVLTAAHCIQSSE-------------------
--SFRNLQVLLGAH-NRTSPT--GDEQYTYAAKICPHQDFEPV----TYDNDIMLLKLAS
EADINTWVAPIPLA-SYLVDDNSECLASGWGSTTSPEETYPGELQCVNITTVSNSDCQ--
DYYPRDTITDNMLCAGDVAGGKDTCGGDSGGPLVCNEELHGITSWGDLVCGSPDKPGVFA
----KVSNY------IDW ISDVMENEAPCNTDISNNNQFLSLIFS----FIYSTYMCADG
TQLYLSTPPLSS--CPFPSKKRPP-ALSNMIGSNP----HSAN---------------VL
TLSSTANS-TSHFFST-----CKSPS------SL--QRTYLPTCSFQARYYDR IIGGTEC
RPNSQPWQCSLYY----FDQHVCGG-VLIDENWV------LTAAHCQLSVHNALYSFFSR
SLQV---------------RLGEHNLAVYEGKEQFSYAEKMCPHSGF--------NPITF
DNDIMLLKLVSPVTINDYVQTIPLGCPTVGDG-ETCLVSGWGTTTSPEE-----------
-------TFPDELQ-CVEVQ--------TVSQ-------DYCQGAFPTDEITDNMLCAGV
ME------GGKDSC---QG---------DSGGP---------LV-CNSM-VHGIT--SWG
NT-PCGVANKPGIYTKICNYIAWI------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------MKLP-------LS--------------L-M-LLSLLAG-HSEADTRAIGARECP
RHSQ-PWQAGLFY-LTRPLCGATLVSDRWLLTAAHCRK------S---------------
-----HLWVRLGEH-NIWQVEG--PEKLLLATDFFPHPGFNSDLTANDHNDDIMLIRLPR
RVQLSPAVQPLNLS-QSLPTPGTQCLISGWGSVSTPKMKYPLTLQCANISILDNRLCR--
RAYPGH-ISDKMLCAGLWEGGRGSCQGDSGGPLVCNGTLAGIVSGGSDPCSRPQRPAVYT
----SVYHY------IDWVQKTMDDNY---------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------M----RR
PGRLKS---DWKLST---------------V--------------PREPGVRPAL-----
LQAMVILRF-------------------------IA-LALVT-G-LVGGETRIIKGYECT
PHSQ-PWQVALFQ-KTRLLCGATLIAPKWLLTAAHCRKP---------------------
-----HYVILLGEH-NLEKTDG--YEQKRVATESFPHPGFNNSLPNKDHRNDIMLVKMSS
PAIITRAVRPLTLS-SHCVAAGTSCLISGWGTTSSPQLRLPHSLRCANVSIIEHRECE--
SAYPGN-ITETMLCASVRKEGKDSCQGDSGGPLVCNGSLQGIISWGQDPCAVTRKPGVYT
----KVCKY------TDWIHEIMKNN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
-----------------MGRPPPG-AVLIWMFLLLPLEAWAASGSQGLR--IERQVDNLS
CVHLNKQS--FSSC---------CCR------REWQSNSLLLAVGHLRAQEPKILEGKEC
EPHSQPWQVALFQ----GVRLLCGG-VLIDDNWV------ITAAHCKKS-----------
NYTV---------------HLGEHSLQSKDRLEQEIAVAESIPHPCYN-----RG-SEDH
RHDVMLIRLRSQAFLGPEVKAIKLADRCPQAG-QHCTISGWGTVTSPRE-----------
-------NFPDTLN-CAEIQ--------IIPQ-------KQCKDAYPG-KITDSMVCAGD
S-------SGADTC---QG---------DSGGP---------LV-CDGV-LQGIT--SWG
SD-PCGRPEKPGVYTSLCRYLDWIKKTIGKRV----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------MKLG-------LT--------------L-V-LLSLLAG-HCGADTRAVGARECQ
RNSQ-PWQAGLFY-LTRQLCGATLISDRWLLTAAHCRK------P---------------
-----YLWVRLGEH-HLWQWEG--PEKLLLATDFFPHPGFNSDLSANDHNDDIMLIRLPR
KVQMSAAVQPLNLS-QSLPTVGSQCLISGWGSVSSSKLQYPMTLQCANISILDNRLCR--
WAYPGH-ISEKMLCAGLWEGGRGSCQGDSGGPLVCNGTLAGIVSGGSEPCSRPQRPAVYT
----SVCHY------RDWVQKTMEEN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------MA------MELLNIVLLLVPAALAQTDTRIVGGYPC
EK-PQPWQAAIFN----EHQLYCGG-VLINKEWV------MTAAHCVLR----------G
TTSI---------------RVGEYNLRQMDESEQVKMAAKSVAHPNY--------NPATK
DNDIMLIKLSSPVQLNNNVHPIALASSAAPAG-IVCLVSGWGTTTTPKP-----------
-------SFPALLQ-CANLE--------IISD-------SDCRRTYPG-LITDNMLCAGV
PQ------GGTDSC---QG---------DSGGP---------LV-CGRS-LQGIV--SWG
LE-ECAQPNKPGVYSKVSKYLDWIQQTIRAG-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------MF--VLLTALQILAVAMIQSQA-DESKIIGGHPC
IQNSQPWQVALLAG--PGRRFLCGG-ALLSDRWA------ITAAHCARR-----------
ILWV---------------ALGKHNLKKWEATQQVLRVVRQVPHPQY--------NSRTH
NNDLMLLQLGQPARLGRAVRPIPVANSCASPG-TPCRVSGWGTTSSPNA-----------
-------RYPNSLQ-CVNIN--------IISDQD-------CRQAYSR-AITSGMVCAGV
PQ------GGKDSC---QG---------DSGGP---------LV-CREQ-LQGLV--SWG
ME-RCAQPGYPGVYTNLCKYQNWIQGTIRSR-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----MW---PLAAA-LTCLTVALSGGISQDYPKIL------NG-TNGTSGFLPGGYTCL
PHSQ-PWQAALLV-RGRLLCGGVLVHPKWILTAAHCRKP---------------------
-----GYKVYLGKH-SLRRVE--NGEQSREVVRSVPHPEYQVSPTHMNHDHDIMLLELES
PVQLSGHIRTLPLSEDDCLPAGTCCRVSGWGTTTSPQVSYPQTLQCANIELRSDEECR--
QVYPGK-ITANMLCAGTKEGGKDSCEGDSGGPLVCNHRLHGIISWGDFPCGQPNRPGVYT
----RVSKY------LHWIHETIEQNQPQEERRTKGTQ----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------MA------MKMLTVALVLLAGAFAEEQEKLVHGGPC
HRDSHPYQAALYN----SGHLLCGG-VLIDPEWV------LTAAHCKKE-----------
KLHV---------------YLGKHNLRQSKNTE-DISVIKTVVHPGY--------NPATH
DQDIMLLRLSKPAKLSDWIQPLPLERDCGARS-PRCHILGWGKTE--QG-----------
-------VFPDTIQ-CAYVH--------IVPQ-------EKCDQAYPG-QITRNMVCAGD
PE------EGKDAC---QG---------DSGGP---------LV-CGGR-LRGLV--SWG
NV-PCGSKEKPGVYTDVCRYVSWIQRTMRGHWP---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------MPMKMLT------MKMLALCLVLAKSAWSEEQEKVVHGGPC
LKDSHPFQAALYT----SGHLLCGG-VLIDPQWV------LTAAHCKKP-----------
NLQV---------------ILGKHNLRQTETFQRQISVDRTIVHPRY--------NPETH
DNDIMMVHLKNPVKFSKKIQPLPLKNDCSEEN-PNCQILGWGKME--NG-----------
-------DFPDTIQ-CADVH--------LVPR-------EQCERAYPG-KITQSMVCAGD
MK------EGNDSC---QG---------DSGGP---------LV-CGGR-LRGLV--SWG
DM-PCGSKEKPGVYTDVCTHIRWIQNILRNKWL---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------M----QR
LRWLQDRKSSGRGLA---------------A--------------AKEPGARPSP-----
LQAMRILQL-------------------------IM-LALVT-G-LVAGETRIIKGVECK
PHSQ-PWQAALFE-KTRLLCGATLIAPRWLLTAAHCRKP---------------------
-----RYIVHLGEH-NLQRRDG--CEQTRTATESFPHPGFNNSLPNKDHRNDIMLVKMAS
PAFITWAVRPLTLS-SRCVTAGTSCLISGWGSTSSPQLRLPHSLRCANITIIEHHECE--
HAYPNN-ITDTMVCASVQEGGKDSCQGDSGGPLVCNHSLQGIISWGQDPCAITRKPGVYT
----KVCKY------VDWIQETMNNN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------MRRLIAALVLVAAAWAEEQEKVVQGGPC
EETSHPYQAALYT----SGHLLCGG-VLIHPLWV------LTAAHCKKP-----------
NLQV---------------YLGKHNLQQRESSQEQSSVVRAVTHPGY--------DAATH
DQDIMLLRLAHRAKLSEHIQPILLEKDCSANH-TSCHILGWGKTA--DG-----------
-------DFPDTIQ-CAYIH--------LVPR-------EECERAYPG-QITQNMVCAGD
EK------HGKDSC---QG---------DSGGP---------LV-CGDR-LRGLV--SWG
NI-PCGSKEKPGVYTNVCRYNNWIRKIIQAN-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----MW---PLAVV-ISLLTVTLSGGISREYPKII------NS-TNGTSGLLPGGYTCQ
PHSQ-PWQVALLV-QGRLLCGGVLVHPKWVLTAAHCLKE---------------------
-----GYRVYLGKH-ALGRVE--AGEEVREVVRSIPHPKYQVSPTHLNHDHDIMLLELQA
PVQFSSHIRAMPLSHRDCLPPGTCCRVSGWGTTTSPQXXXXXXXXXXXXXXXXXXXXX--
XXXXXX-XXXXXXXXXXXXXXXXXXXGDSGGPLICNGTLHGIISWGDFPCGQPSRPGVYT
----RVSRY------VQWIRDTIRRHKSREQKWTQGSE----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------MRTWVRSL-------------------ASPCG--
-------L-RILRCCGCGCGCG--CGCGIGGQR---NRIGGI------SANRTTSRQVRS
PAALLLCRPQQQLRSDLWNSNGRAARK--------EKTDRERVSR----WDEL-------
-----------------------------VFGGIQVGA----GGS----------RLNQF
ILSRPQTS-APSPGSSSTMGLL---------LTSHLIFSFLLTCAGAQDDSD-KARGEEC
APHSQPWQVALFE----HGRFNCGA-SLISPNWV------LTAAHCQTR-----------
GMRV---------------RLGEHNLRKRDGPEQLRAVARIIPHPRY--------EERSH
RHDVMLLRLLRPAHLSAKVHPIPLPTRCPRPG-EACVVSGWGLVSGKEPGA-TG------
-RPESQVSLPDTLH-CGNIS--------VIST-------ASCNKDYPG-CLLNTMVCAGV
EG------GGTDSC---EV---------RAERERWKEEGGGTGLEVGMG-PGGLL-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------MWLLLAFVLLVSA--A-QDGDKVLEGEEC
VPHSQPWQVALFE----RGRFNCGA-FLISPRWV------LTAAHCQTR-----------
FMRV---------------RLGEHNLRKFDGPEQLRSVSRIIPHPGY--------EARTH
RHDIMLLQLFQPARLTAYVRPVALPRRCPLIG-EDCVVSGWGLLSDNNPGA-TG------
-SQKSQVRLPDTLH-CANIS--------IISE-------ASCNKDYPG-RVLPTMVCAGV
KG------GGTDSC---EG---------DSGGP---------LV-CGGA-LQGIV--SWG
DV-PCDTTTKPGVYTKVCSYLEWIWENVRRY-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----MW---LLSLA----LVLALSQASSQEFPKIL------NS-SNGSQGALPGIQACA
PHSQ-PWQAALLV-NQRLLCGGILIHPCWVLTAAHCLKD---------------------
-----QYTVFLGKH-SLNYRE--AGEQVRRVVHSIPHPLYRRSPTHHNHDHDIMLLYLQK
PAQLNRHVQVLPLPSQDCLPPGTNCTVSGWGTTTSPQVTYPTTLQCAEIQLRSDEECH--
LNYPGK-ITPNMLCAGSEEGGKDSCEGDSGGPLVCNGTLQGVISWGDFPCGQPNRPGVYT
----RVSRY------VKWIQNTIKAGDPRRNKWDGIKSQ----S----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------XXXXXXXSGGISQDYPKIL------NG-TNGTSGFLPGGYTCH
PHSQ-PWQAALLV-KGRLLCGGVLVHTKWVLTAAHCLKD---------------------
-----GYRVYLGKH-ALGRAE--TGEQVKEVVRSIPHPEYQSSPTHLNHDHDIMLLEMET
PVKLTNHIRVLALSHSNCLPPGTCCRVSGWGTTTSPQVSYPKTLQCANIELRSDKECH--
QVYPGK-ITSNMLCAGTKEGGKDSCEGDSGGPLVCNKTLHGIISWGDFPCGQPNRPGVYT
----RVSKY------VPWIRETIRKYETREQKWTKGPQ----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------GGGPGGPDED
GALSSPWQVALFE----RGRFNFGA-SLISSRWG------LAAAHCQTL-----------
FMRA---------------RLGEHNLRKRDGPEQLIAVSRLIPHPGY--------ESRSH
LHDIMLVRLARPARLSRQVRPVALPTHCPHQG-EPCVVSGWGLVSNSKPDT-PG------
-SSHSQVNPPDTLH-CANIS--------IISD-------ASCNKDYPG-RLTDTMVCAGV
XX------XXXXXX---XG---------DSGGP---------LI-CRGA-LQGIV--SWG
DV-PCDTTTKPGVYTKVCRYIGWIQETMRIN-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------M----RK
PRWLKDGKSFH-GGH---------------T--------------EKEPGACPSL-----
FQGMTILQL-------------------------IM-LALGT-G-HVGGETRIIKGYECT
PHSQ-PWQVALFQ-KTRLLCGATLIAPKWLLTAAHCRKP---------------------
-----LYAVHLGXX-XXXXXXX--XXXTRMATESFPHPGFNNILPNKDHRNDIMLVKMTT
PAKITRAVRPITLS-SHCVTAGTRCLISGWGTTSSPQLHLPHSLRCANITIIEHKQCE--
DAYPGN-ITDTMLCASVQEEGKDSCQGDSGGPLVCNDSLQGIISWGQDPCAVTRKP-VYT
----KVC-Y------VNWIQKTMENN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----MW---PLAAA-ISFLTVAWSGGISREYPKIL------NG-TNGTNGFLPGGYTCT
PHSQ-PWQAALQV-HGRLLCGGVLVHPRWVLTAAHCLK--E-------------------
-----GYRVYLGKH-VLARVE--AGEQVREVARAIPHPQYQSSPTHLNHDHDIMLLELKS
SVQLTRHIQTLPLSRQHCLPPGTCCRVSGWGTTTSPQVTYPQTLQCANIELRSDEECH--
RVYPGK-ITPNMLCAGTKEGGNDSCEGDSGGPLVCNGKLHGIISWGDFPCGQPNRPGVYT
----RVSQY------VPWIQETIRKGKTWQQEWAKGPQ----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------MWPLLAVSFLLTCAAAQD-GDKMPEGEEC
APHSQPWQVALFE----RGRFNCGG-SLISPDWV------LSAAHCQTR-----------
FMTA---------------RLGEHNLRKRDGPEQLRAISRIIPHPGY--------EARSH
RHDVMLLRLVRPARLTSQVRPVPLPRRCPSPG-EACVVSGWGLVSDNDPGD-TG------
-SPESQVKIPDTLH-CANIS--------IISD-------ASCDKDYPG-RLMSAMVCAGV
PG------GGTDSC---E------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------ISRESSKIL------KG-TNGTSGFLPGGYTCL
PHSQ-PWQAALLV-RGRLLCGGVLVHPKWVLTAAHCMKD---------------------
-----GYTVHLGKH-VLGHVE--TREQVREVARSVPHPEYQVSPTHLNHDNDIMLLELET
PVQLTAHIRTLPLSRSDCLPPGTCCRVSGWGTTTSPQVSYPKTLQCANIPLRSDEECR--
RVYPGK-ITTNMLCAGSKEGGRDSCEGDSGGPLVCNGTLHGIISWGDFPCGQPNRPGVYT
----RVSKY------VSWIHETIKKHKTQGLRWTKSTQ----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------MKLG--------L--------------LCA-LLSLLAG-HGWADTRAIGAEECR
PNSQ-PWQAGLFH-LTRLFCGATLISDRWLLTAAHCRK------P---------------
-----YLWVRLGEH-HLWKWEG--PEQLFRATDFFPHPGFNKDLSANDHNDDIMLIRLPR
QARLSPAVQPLNLS-QTCVSPGTQCLISGWGAVSSPKALFPVTLQCANISILENKLCH--
WAYPGH-ISESMLCAGLWEGGRGSCQGDSGGPLVCNGTLAGVVSGGAEPCSRPRRPAVYT
----SVCHY------LDWIQEIMES-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------MNQG-------IW--------------VSL-LMLLWTG-QGWTDTRTIGAEECT
PNSQ-PWQAGLFF-LTRLFCGATLLSDRWLLTAAHCRK------P---------------
-----YLWVRLGEH-HLWQWEG--PEQLFRVTDFFPHPGFNSDLSARDHNHDLMLIRLKR
PARLNPAVQPLNIS-KSCVRPGTTCLISGWGAISSPDVEYPLTLQCANISVLEPRLCH--
RAYPGR-ISSNMICAGLWEGGRGSCQGDSGGPLVCNGALEGVVSGGAEPCSKPKRPAVYT
----SVCRY------RDWIHQTMKEN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----MW---PLALV-IASLTVALSGGISQESSKVL------N--TNGTSGFLPGGYTCF
PHSQ-PWQAALLV-RGRLLCGGVLVHPKWVLTAAHCLKE---------------------
-----GLKVYLGKH-ALGRVE--AGEQVREVVYSIPHPEYRRSPTHLNHDHDIMLLELQS
PVQLTGYIQTLSLSHNNRLTPGTTCRVSGWGTTTSPQVNYPKNLQCANIQLRSDEECH--
QIYPGK-ITDNMLCAGTKEGGKDSCEGDSGGPLVCNRTLYGIISWGDFPCGQPDRPGVYT
----RVSRY------VLWIRETIRKYETQQQKWLKGPQ----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------MSLR---------------------------------------------
-----------VLGSG-TWPSAPKMF----LLLTALQVLAIDMTRSQE-DENKIIGGYTC
TRSSQPWQAALLVG--PGRRFLCGG-ALLSDQWV------ITAAHCGRP-----------
ILQV---------------ALGKHNLRRWEATQQVLRVVRQVTHPDY--------NSRTH
ENDLMLLRLQQPARIGRAVRPIEVAQACASPG-TSCRVSGWGTISSPIA-----------
-------RYPASLQ-CVNIN--------ISPDEV-------CQKAYSK-AITPGMVCAGV
PQ------GGKDSC---QG---------DSGGP---------LV-CRGQ-LQGLV--SWG
ME-RCALPGYPGVYTNLCKYRSWIEETMRHK-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----MW---SLTAV-IASLTVALSGGISQEYPKII------NS-TNGTNGFLPGGYTCL
PHSQ-PWQAALLV-RGRLLCGGVLVHPRWVLTAAHCLKE---------------------
-----GYKVYLGKH-ALGRVE--ASEQVREVVRSIPYPEYRSSPTHLNHDHDIMLLELQS
PVQLTGHVRILPLSHNDYPLPGTCCRVSGWGTTTSPQVSYPKTLQCANIQLRSDEECR--
QVYPGK-ITPNMLCAGTKEGGKDSCEGDSGGPLVCNGTLHGIISWGDFPCGQPDRPGVYT
----RVSRY------VSWIRETIQKHKTQEQIRTKDP-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----MILRL-------------------------IL-LALVI-G-HVGGETRIIKGYECR
PHSQ-PWQVALFQ-KTRLLCGATLIAPKWLLTAAHCRKP---------------------
-----QYLVHLGEH-NLQRWDG--YEQTRTATKSFPHPHFNNSLPNKDHRNDIMLVKMSS
AAVITRAVRPLTLS-SQCVTAGTSCLISGWGTTSSPQLRLPHTLRCANITIIEHQECK--
KAYPGN-ITDTMVCASVGEEGKDSCQGDSGGPLVCNGSLQGIISWGQDPCAVTRKPGVYT
----KVCKY------VDWIRDTMENN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----MW---PLVAT-IACLTLALSEGISRDYPKIL------NG-TNGTSGFLPGGYTCL
PHSQ-PWQAALLI-RGRLLCGGVLVHPKWVLTAAHCRKD---------------------
-----GYTVHLGKH-ALGRVE--NGEQAMEVVRSIPHPEYQVTPTHLNHDHDIMLLELKS
PVQLSSHVRTLKLSADDCLPTGTCCRVSGWGTTTSPQVNYPKTLQCANIELRSDEECR--
QVYPGK-ITANMLCAGTKEGGKDSCEGDSGGPLICNGKLYGIISWGDFPCGQPNRPGVYT
----RVSKY------LRWIREIIRNTPEQ--RWTKGTQ----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------MGQPPPAAACT-PTLLLLL----GE------------------
--AWA---------------------------------------GHLRTQGSKVLEGQEC
NAHSQPWQTALFQ----GISLLCGG-VLIDENWV------LTAAHCQKR-----------
KYSV---------------RLGDHSLKNNDGTEQEMTVAQSIPHPCYN-----RS-SEDH
SHDIMLVRLRGRATIGPSVKPIRLPDRCPEAG-QKCTISGWGTVTSPQE-----------
-------NFPDTLN-CANVE--------IFPQ-------KQCKEAYPG-QVTDGMVCAGD
S-------TGADTC---QG---------DSGGP---------LV-CNNH-LQGIT--SWG
SD-PCGRPERPGVYTNVCRYLDWIKKTIGSRG----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------MKKLMVVLSLIAAAWAEEQNKLVHGGPC
DKTSHPYQAALYA----SGHLLCGG-VLIHPLWV------LTAAHCKKP-----------
NLQV---------------FLGKHNLRQRESSQEQSSVVRAVIHPGY--------DAATH
DQDIMLLRLARPAKLSELIQPLPLERDCSANT-TSCHILGWGKTA--DG-----------
-------DFPDTIQ-CAYIH--------LVPR-------EECEHAYPG-QITQNMLCAGD
EK------YGKDSC---QG---------DSGGP---------LV-CGDH-LRGLV--SWG
NI-PCGSKEKPGVYTNVCRYTNWIQKTIQAK-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------M----RR
LRWFKG---DRKSPT---------------A--------------AREPGARPAP-----
LQAMMILRF-------------------------VT-LALVT-G-HVGGETRIIKGYECT
PHSQ-PWQVALFQ-KTRLLCGATLIAPKWLLTAAHCRKP---------------------
-----QYVVLLGEH-NLQRADG--CEQKRTATKSFPHPDFNNSLPNKDHRNDIMLIKLSS
AAFITRAVRPLTLS-SHCVKAGTRCLISGWGTTSSPQLRLPHSLRCANISIIGHEECE--
KAYPGN-ITDTMLCASVGKEGKDSCQGDSGGPLVCDGSLQGIISWGQDPCAVTRKPGVYT
----KVCKY------VDWIHHTMRNN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------MGRPSP-AAVWIWMLLLLLSES---------------------
------------------------------------------RAGHLRAQESKVLEGKEC
KPHSQPWQTALFQ----GVRLICGG-VLIDDNWV------LTAAHCQKK-----------
KYTV---------------RVGEHSLKNKDESEQERAVAQSIPHPCYN-----SS-NNDH
SYDLMLIQLRGRVPLGPKVKPIKLADHCPQVG-QKCTISGWGTVTSPRE-----------
-------NFPDTLN-CAEVK--------IISQ-------HQCEKAYPG-QVTDSMVCASD
S-------SGADTC---QG---------DSGGP---------LV-CNGV-LQGIT--SWG
SD-PCGRPEKPGVYSKVCHSLDWIKKTIGSRG----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------MWLLLPLSFLLASTAAQ-DGDKLLEGEEC
APHSQPWQVALYE----RGRFNCGA-SLISPHWV------LSAAHCQSR-----------
FMRV---------------RLGEHNLRKRDGPEQLRTASRVIPHPRY--------EARSH
RHDIMLLRLVQPARLTPQVRPVVLPTRCPHPG-EACVVSGWGLVSHNEPGT-TG------
-SPQSQVSLPDTLH-CANIS--------IISD-------ASCDKNYPG-RLTNTMMCAGA
NG------RGAESC---EG---------DSGGP---------LV-CGGI-LQGIV--SWG
DV-PCDNTTKPGVYTKVCRYVKWIRETMKRN-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------MRLG--------F--------------VCA-LFSLLAG-HGWADTRAIGAEECR
PNSQ-PWQAGLFY-LTHLFCGASLISDRWLLTAAHCHK------P---------------
-----YLWVRLGEH-HLWQWEG--PEQLFRATDFFPHPGFNKDLRAHDHSDDIMLIRLPR
KAHLGPAVQPLNLS-QTCVSPGTQCLISGWGAVSSPKVQYPLTLQCANISILDHNLCR--
WAYPGH-ISDSMLCAGLWEGGRGSCQGDSGGPLVCDGTLAGVVSGGAEPCSRPWRPAVYT
----SVCHY------VDWIRKTMEDN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------MKLG--------L--------------LCA-LLSLLAG-HGWADTRAIGAEECR
PNSQ-PWQAGLFH-LTRLFCGATLISDRWLLTAAHCRK------P---------------
-----YLWVRLGEH-HLWKWEG--PEQLFRVTDFFPHPGFNKDLSANDHNDDIMLIRLPR
QARLSPAVQPLNLS-QTCVSPGMQCLISGWGAVTSPKALFPVTLQCANISILENKLCH--
WAYPGH-ISDSMLCAGLWEGGRGSCQGDSGGPLVCNGTLAGVVSGGGEPCSRPRHPAVYT
----SVCHY------LDWIQETMEN-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------ML----LLFSALQVLAVAMAQSPE-NDNKIIGGYTC
IQNSQPWQVALLAG--AGRQFLCGG-VLLSDQWV------ITAAHCARP-----------
ILYV---------------AVGKHNLRRWEATQQILPVQRQVPHPGY--------NARTH
NNDLMLLRLRQPLRIGRAVRPIPLAQSCASKG-TPCLVSGWGTISSPIA-----------
-------RYPNALQ-CVNIN--------IMSDQQ-------CQQAYPG-AITAGMVCAGV
PQ------GGKDSC---QG---------DSGGP---------LV-CGGK-LQGLV--SWG
ME-RCALTGYPGVYTNLCKYRSWIQRTMQ-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------MPL--------------------------------------------------
-----------RLVSV-IRPPALRMF----LLLMALQILAVATAQNQG---DKIIGGSRC
IRNSQPWQAALLAG--PHRSFLCGG-SLLSDEWV------ITAAHCARP-----------
NLRV---------------ALGKHNLRIWEVTQQVLRVVRQVPHPQY--------NPWTI
ANDLMLLQLEQPARLRRAVRPIAVASSCASAG-TPCLVSGWGTTSSPNA-----------
-------RFPKFLQ-CVNIN--------ISSDRD-------CQWAYPG-AITAGMVCAGV
PQ------GGKNSC---QG---------DSGGP---------LV-CRGE-LQGLV--SWG
ME-NCAQ-DYPSVYT-LCKYQTWMQETIQSRS----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------MKLG-------LT--------------FLV-LLSLLAD-HCGADTRAVGARECQ
RHSQ-PWQAGLFY-LTRQLCGATLISDRWLLTAAHCRK------P---------------
-----YLWVRLGEH-HLWQWEG--PEKLLLATDFFPHPGFNADLSANDHNDDIMLIRLPR
KVQMSAAVQPLNLS-QSLPNVGSQCLISGWGSVSSSKLQYPMTLQCAYISILDNKLCR--
WAYPGH-ISEKMLCAGLWEGGRGSCQGDSGGPLVCNGTLAGIVSGGSEPCSRPQRPAVYT
----SVCHY------RDWIQKTMEEN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------MWLLLPLSFLLAST-AQ-DGDKLLEGEEC
APHSQPWQVALYE----RGRFNCGA-SLISPHWV------LSAAHCQSR-----------
FMRV---------------RLGEHNLRKRDGPEQLRTASRVIPHPRY--------EARSH
RNDIMLLRLVQPARLTPQVRPVVLPTRCPHPG-EACVVSGWGLVSHNEPGT-TG------
-SPRSQVSLPDTLH-CANIS--------IISD-------ASCDKNYPG-RLTNTMVCAGA
EG------RGAESC---EG---------DSGGP---------LV-CGGI-LQGIV--SWG
DV-PCDNTTKPGVYTKVCHYVKWIRETMKRN-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------VKMLVIALVLFAAAQAEEQNKVLHGGPC
EQTSHPYQAALYT----SGHLLCGG-VLIHPLWV------LTAAHCKKP-----------
NLQV---------------YLGKHNLQQRELFQEESPVIRTMVHPGY--------NAATH
DQDIMLLRLSRPARFSEHIQPLALERDCSANH-TSCHILGWGKMA--DG-----------
-------EYPNTIQ-CAYIH--------LVSR-------EECEHAYPG-QITQNMVCAGD
EK------HGKDSC---QG---------DSGGP---------LV-CGDR-LRGLV--SWG
NV-PCGSKEKPGVYTDVCRYGHWIQRVIQAN-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------MKKLMVVLSLIAAAWAEEQNKLVHGGPC
DKTSHPYQAALYT----SGHLLCGG-VLIHPLWV------LTAAHCKKP-----------
NLQV---------------FLGKHNLRQRESSQEQSSVVRAVLHPGY--------DAATH
DQDIMLLRLARPAKLSELIQPLPLERDCSANT-TSCHILGWGKTA--DG-----------
-------DFPDTIQ-CAYIH--------LVPR-------EECERAYPG-QITQNMLCAGD
EK------YGKDSC---QG---------DSGGP---------LV-CGDH-LRGLV--SWG
NI-PCGSKEKPGVYTNVCRYTNWIQKTIQAK-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------MGYPPP-AAMWTWMFLLLLEACTACE-SQGPH--TRVCAENLG
C-VWNARW-FSPPL---------HCP------REWQPNTLPPAAGHWRAQEPKVLGGKEC
EAHSQPWQSALFQ----GDRLVCGG-VLIDNNWI------ITAAHCKKP-----------
RYTV---------------RLGDHSLHKKDEPEQEKAVAQSIPHPCYN-----SG-SDNH
NHDLMLIRLRSPASLGPKVKPINLTDHCPRVG-QKCTISGWGTVTSPQE-----------
-------NFPDTLN-CAEVE--------VFPL-------KRCEDVYPG-QVSEGMICAGD
T-------RGADSC---QG---------DSGGP---------LV-CDGV-LQGIT--SWG
SD-PCGKPQRPGVYTNLCRYLDWIKKTIGSKG----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------MWLLLTLSFLLASSAAQ-DGDKSLEGDEC
APHSQPWQVALYE----RGRFNCGA-SLISPHWV------LSAAHCQTR-----------
FMRV---------------RLGEHNLRKRDGPEQLRTASRVIPHPRY--------EARSH
RHDIMLLRLVRPARLTPQVRPVVLPTRCPHPG-EACVVSGWGLVSHIEPGT-TR------
-SPQSQVSLPDTLH-CANIS--------IISD-------TSCDKSYPG-RLTNTMVCAGA
DG------RGAESC---EG---------DSGGP---------LV-CGGT-LQGIV--SWG
DV-PCDNTTKPGVYTKVCHYLKWIRETMKRN-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----MW---PLVAT-IACLTLALSGGISRDYPKIL------NG-TNGTSGFLPGGYTCL
PHSQ-PWQAALLV-RGRLLCGGVLVHPKWVLTAAHCRKD---------------------
-----GYTVHLGKH-ALGRVE--NGEQAMEVVRSIPHPEYQVSPTHLNHDHDIMLLELKS
PVQLSNHVRTLQLSADDCLPTGTCCRVSGWGTTTSPQVNYPKTLQCANIELRSDEECR--
QVYPGK-ITANMLCAGTKEGGKDSCEGDSGGPLICNGKLYGIISWGDFPCGQPNRPGVYT
----RVSKY------LRWIQGTIRNTPEQ--GWTKGTQ----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------MKLG--------L--------------LCA-LLSLLAG-HGWADTRAIGAEECR
PNSQ-PWQAGLFH-LTRLFCGATLISDRWLLTAAHCRK------P---------------
-----YLWVRLGEH-HLWKWEG--PEQLFRATDFFPHPGFNKDLSANDHNDDIMLIRLPR
QARLSPAVQPLNLS-QTCVSPGTQCLISGWGAVSSPKALFPVTLQCANISILENKLCH--
WAYPGH-ISDSMLCAGLWEGGRGSCQGDSGGPLVCNGTLAGVVSGGAEPCSRPRRPAVYT
----SVCHY------LDWIQEIMES-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------ATMEKLV------VKMLAMCLVLANPAWTEEQEKVVHGGPC
LKNSHPFQAALYT----SGHLLCGG-VLVDAQWV------LTAAHCKKP-----------
NLEV---------------FLGKHNLRQTENFQRQISVDQTIIHPRY--------NPDTH
DNDIMMVHLKNKVKFSQKIQPLPLRRDCFEEK-PSCQILGWGKME--NG-----------
-------DFPDTIQ-CADVQ--------LVSR-------KECERAYPG-KITQNMVCAGD
KE------EGNDSC---QG---------DSGGP---------LV-CGGH-LRGLV--SWG
NM-PCGSKEKPGVYTDVCTYIRWIQNIIKNKQL---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------M----RR
PGRLKS---DWKLST---------------V--------------PREPGARPAL-----
LQAMVILRF-------------------------IT-LALVT-G-LVGGETRIIKGYECT
PHSQ-PWQVALFQ-KTRLLCGATLIAPKWLLTAAHCRKP---------------------
-----RYVILLGEH-NLEKTDG--YEQKRMATESFPHPGFNNSLPNKDHRNDIMLVKMSS
PAILTRAVQPLTLS-SHCVTAGTSCLISGWGTTSSPQLRLPHSLRCANVSIIEHKECE--
NAYPGN-ITETMLCASVRKEGKDSCQGDSGGPLVCNGSLQGIISWGQDPCAVTRKPGVYT
----KVCKY------TDWIYEIMKNN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------MWLLLTLSFLLASSAAQ-DGDKLLEGDEC
TPHSQPWQVALYE----RGRFNCGA-SLISPHWV------LSAAHCQTR-----------
FMRV---------------RLGEHNLRKRDGPEQLRTASRVIPHPRY--------EARSH
RHDIMLLRLVQPARLTPQVRPVVLPTRCPHPG-EACVVSGWGLVSHIEPGT-TR------
-SPQSQVSLPDTLH-CANIS--------IISD-------TSCDKSYPG-RLTNTMVCAGA
EG------RGAESC---EG---------DSGGP---------LV-CGGV-LQGIV--SWG
DV-PCDNTTKPGVYTKVCHYLKWIRETMKRN-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---MRILRL-------------------------IT-LALVT-G-HVGGETRIIKGYPCR
PHSQ-PWQVALFQ-KTRLLCGATLIAPRWLLTAAHCRKP---------------------
-----HYQVLLGGH-NLHQDDG--CEQRQTATESFPHPHFNNSLPNKDHRNDIMLVKLPK
AASITRAVRPLALP-SRCVTAGTSCLISGWGTTSSPQLRLPHTLRCANISIIQHEECE--
GAYPGN-ITDTMVCASVQ-KGKDSCQGDSGGPLVCNGYLQGIISWGQDPCAVSRKPGVYT
----KVCKY------VDWIQKIMHNN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----MW---PLALV-IASLTVALSGGISQESSKVL------N--TNGTSGFLPGGYTCF
PHSQ-PWQAALLV-QGRLLCGGVLVHPKWVLTAAHCLKE---------------------
-----GLKVYLGKH-ALGRVE--AGEQVREVVYSIPHPEYRRSPTHLNHDHDIMLLELQS
PVQLTGYIQTLSLSHNNRLTPGTTCRVSGWGTTTSPQVNYPKTLQCANIQLRSDEECR--
QVYPGK-ITDNMLCAGTKEGGKDSCEGDSGGPLVCNRTLYGIISWGDFPCGQPDRPGVYT
----RVSRY------VLWIRETIRKYETQQQKWLKGPQ----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------MKLG-------LT--------------L-V-LLSLLAG-HCGANTRAVGARECQ
LHSQ-PWQAGLFY-FTRQLCGATLISDRWLLTAAHCRK------P---------------
-----YLWVRLGEH-HLWQWEG--SEKLLLARDFFPHPGFNSDLSANDHNDDIMLIRLPR
KVQMSAAVQPLNLS-RSLPTVGSQCLISGWGSVSSSKLQYPMTLQCANISILDNKLCH--
WAYPGH-ISEKMLCAGLWEGGRGSCQGDSGGPLVCNGTLAGIVSGGAEPCSRPQRPAVYT
----SVFHY------RDWVQKTIEEN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------MSLR---------------------------------------------
-----------ALGSG-TWPSAPKMF----LLLTALQVLAIDMTRSQE-DENKIIGGYTC
TRSSQPWQAALLAG--PGRRFLCGG-ALLSDQWV------ITAAHCG R------------
------------------------------------------------------------
------------------------------------------------------------
-------R YPASLQ-CVNIS--------ISPDEV-------CQKAYSK-AIAPGMVCAGA
PQ------GGKDSC---QG---------DSGGP---------LV-CRGQ-LQGLV--SWG
ME-RCALPGYPGVYTNLCKYRSWIEETMRHK-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----MW---PLALV-IASLTAALSGGISQESSKVL------N--TNGTSGFLPGGYTS-
----------LLV-QGGLLCGGVLVHPKRVLTAAHCLND---------------------
-----GLKVYLGKH-ALGRVE--AGEQVREVVHSIPHPAYRRSPTHSNHDHDIMLLELQS
LAQLTGYILTLPLSHNNCLTPGTTCQVSGWGTATSPQVNYSKTLQCANIQLGSDEECH--
QVYPGK-ITDNMLCASTKEGGKDSREGDSGGPLVCNRTLYGIISWGDFPCGQPD------
-------QC------VLWIRETVRKYETQQQKWLKGPQ----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------QCGEDEEKIIGGHMW
IPNSQPWQAALLAN----GNFHCEG-L-LSNCWV------LTAAHCNHW-----------
NLRV---------------VLGKHNIRCLEPSQQSVGVERRVPHPSY--------SPRTS
NNDLMLLYLEKPVKLTNQVKPIQLAKNCANLG-TDCLVSGWGTVSSPF------------
-------------Q-CLKIS--------IFSEET-------CKNAYYGKAITPGMVCAGD
KK------GGKDSC---QG---------DSGGP---------LV-CSGV-LQGLV--SWG
ME-HCALPGYPGVYTNLCHYRTWILNEMQKN-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------EPGACPPP-----
LQAMTILGL-------------------------IT-LALVTXX-XXXXXXXXXXXXXXX
XXXX-XXXXXXXX-XX--------X-------------------XXXXXXXXXXXXXXXX
XXXXXXXXVLLGEH-NLQRQDG--YEQTRLATESFPHPDFNDSLPNKDHRNDIMLVKLAT
PAVFTWAVRPLTLS-SHCVTPGTRCLISGWGTTSSPQIHLPHTLRCANITIIDHEQCE--
DAYPGN-ITDTMVCASVKKEGKDSCQGDSGGPLVCNGSLQGIISWGQDPCAVTKKPGVYT
----KVCKY------VDWIHKTMKNN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----TW---PLASA-MAFLTVALSGGMSQEYPKIL------NG-TNGTNGFLPGGYTCP
PHSQ-PWQAALLV-QGRLLCGGVLVHPRWVLTAAHCLKT---------------------
-----GFRVYLGKH-ALGRVE--AGEQVRDVVRHIRHPQYQSSPTHLHHDHDIMLLELRS
PVQSTSYIRVLPLSYRDCLPPGTGCRVSGWGTTTSPQVSYPKTLQCADIQLRSDEECR--
QKYPGK-ITPNMLCAGTKEGGQDSCEDFDGPP--CDGMLCGIFSCRDFSFGQPKHPGVYT
----V--SY------VLWIETI----KTQEQKWKSPQ-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------MSLR---------------------------------------------
-----------APVSA-TRRPGPRML----LPLMALQLLAVAVAQSQT-DENKIIGGYTC
IQHSQPWQAALLAG--PMHRFLCGG-VLLSDRWA------ITAAHCARM-----------
ILWV---------------ALGKHNLRRREATQQVLRVARQVLHPQY--------NSRTH
DNDLMLLRLERPARLGRAVRPIAVAQTCASPD-TPCRVSGWGTTSSPAA-----------
-------RYPNPLQ-CVNIN--------ISSDQQ-------CQRAYPG-AITPGMVCAGV
SQ------GGKDSC---QG---------DSGGP---------LV-CGGQ-LQGLV--SWG
ME-RCAQPGYPGVYTNLCKYHTWIQQTMQSK-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------MWLLLGFSLLLASAAAQEDD----KPRGC
VPYSQPWQVALFE----RGRFNCGA-SLISPFWV------LSAAHCQTR-----------
FMRV---------------RLGEHNLRQHDGREQLRMVSRVIPHPRY--------KARSH
LHDLMLLRLVRPARLSAQVHPVALPARCPRAG-EACLVSGWGLVSNDKQSHKGG------
-SGSSQ------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------MF----LLLAALRVLAVAMAQSPE-DDNKIIGGYTC
VQNSQPWQVALLSG--PGRRFLCGG-VLLSDQWV------ITAAHCARP-----------
ILHV---------------ALGKSNLRRWEATQQVLRVERQVPHPRY--------NARTH
DSDLMLLWLSRRARIGRAVRPIGLAGSCASPG-TSCHVSGWGTTSSPIA-----------
-------RYPNALQ-CVNIN--------IVSDGE-------CQRAYPS-TITAGMVCAGV
PQ------GGKDSC---QG---------DSGGP---------LV-CGGQ-LQGLV--SWG
ME-RCAMAGYPGVYTNLCKYRSWVQRTVQG------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------MKKLMVVLSLIAAAWAEEQNKLVHGGPC
DKTSHPYQAALYT----SGHLLCGG-VLIHPLWV------LTAAHCKKP-----------
NLQV---------------FLGKHNLRQRESSQEQSSVVRAVIHPDY--------DAASH
DQDIMLLRLARPAKLSELIQPLPLERDCSANT-TSCHILGWGKTA--DG-----------
-------DFPDTIQ-CAYIH--------LVSR-------EECEHAYPG-QITQNMLCAGD
EK------YGKDSC---QG---------DSGGP---------LV-CGDH-LRGLV--SWG
NI-PCGSKEKPGVYTNVCRYTNWIQKTIQAK-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------MWLLLTLSFLLASSATQ-DGDKSLEGDEC
APHSQPWQVALYE----RGRFNCGA-SLISPHWV------LSAAHCQTR-----------
FMRV---------------RLGEHNLRKRDGPEQLRTASRVIPHPRY--------EARSH
RHDIMLLRLVQPARLTPQVRPVVLPTRCPHPG-EACVVSGWGLVSHMEPGT-TR------
-SPQSQVSLPDTLH-CANIS--------IISD-------TSCDKSYPG-RLTNTMVCAGA
EG------RGAESC---EG---------DSGGP---------LV-CGGI-LQGIV--SWG
DV-PCDNTTKPGVYTKVCHYLKWIRETMKRN-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------MF----LLLSALQVLAVAMAQSPA-DDSKIIGGYPC
IRNSQPWQVALLAG--AGRRFLCGG-VLLSDQWV------ITAAHCARP-----------
ILHV---------------SLGKHNLRRWEATQQVLRVQRQVPHPSY--------NGRTH
DSDLMLLQLRHPARIGRAVRPIGLAQSCASPG-TPCRVSGWGTTSSPIA-----------
-------RYPNALQ-CVNIN--------IFSDQA-------CQQAYPG-AITAGMVCAGV
PQ------GGKDSC---QG---------DSGGP---------LV-CEGQ-LQGLV--SWG
ME-RCALAGYPGVYTNLCKYQSWIQRTMRGQGP---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------MF----LLLTILQVLALALVQGQG--DDKILGGYTC
IPNSQPWQVALQAG--PGRRLVCGG-VLLSDQWV------ITAAHCARP-----------
ILFV---------------AVGKHNLRRWEATQQVVRVVRQVPHPQY--------QPRAH
NNDLMLLQLQKKVRLGRAVRALPVARNCASPG-TPCRVSGWGTTSSPVV-----------
-------RYPNALQ-CVNVN--------IMSEEV-------CRRAYSG-IITSGMVCAGV
PQ------GGKDSC---QG---------DSGGP---------LV-CGGQ-LQGLV--SWG
ME-RCAMPGFPGVYTNLCNYQNWIQKTMQGN-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------MKLG--------L--------------LCA-LLSLLAG-HGWADTRAIGAEECR
PNSQ-PWQAGLFH-LTRLFCGATLISDRWLLTAAHCRK------P---------------
-----YLWVRLGEH-HLWKWEG--PEQLFRVTDFFPHPGFNKDLSANDHNDDIMLIRLPR
QARLSPAVQPLNLS-QTCVSPGMQCLISGWGAVSSPKALFPVTLQCANISILENKLCH--
WAYPGH-ISDSMLCAGLWEGGRGSCQGDSGGPLVCNGTLAGVVSGGAEPCSRPRRPAVYT
----SVCHY------LDWIQEIMEN-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------MSVPVWQRVGAWTSL--TKLYAENLP
CVHLNLQW-PSQPW---------HCP------RGWRSNPLPPAAGHSRAQEEKVLGGQEC
QPHSQPWQAALFQ----GKQLLCGG-VLIGGNWI------LTAAHCKKP-----------
KYTV---------------RLGDHSLHNKDGPEQEIPVVQSIPHPCYN-----SSDVDDH
NHDLMLLQLRDQASLGPKVKPINLADHCTQPG-QTCIISGWGTVTSPRE-----------
-------NFPDTLN-CAEVK--------IFPQ-------KKCEDAYPG-QITDGMVCAGS
S-------KGADTC---QG---------DSGGP---------LV-CNGA-LQGIT--SWG
SD-PCGRSDRPGVYTNICRYLDWIKKTIGSKG----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------MGRPPPG-SVMTWLFLLLLWEAW-TA-CGSVL--GCVHAENLW
CVHLNPQW-SSRPW---------HCP------RGWRSNALPPAAGRARAQTDKVLGGQEC
APHSQPWQTALFQ----GEQLLCGG-VLVGANWV------LTAAHCKKP-----------
KYTV---------------RLGDHSLQSKDGPEQEMSVLQSIPHPCYN-----NS-NDDH
SHDLMLLRLRGRASLGPKVKPINLTDHCPQAG-QKCTVSGWGTVTSPRE-----------
-------NFPDTLN-CAKVN--------IINQ-------KKCEDAYPG-QVTDSMVCAGS
S-------NGADTC---QG---------DSGGP---------LV-CDGV-LQGIT--SWG
SD-PCGLPHKPGVYSNICRYLNWIKKTMGPKG----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------AQ-DAEKVLKGEEC
VPHSQPWQVALFE----KGRFNCGA-SLISPQWV------LSAAHCQSR-----------
SIRV---------------RLGEHNLRKHEGPEQLRVVSRIIAHPGH--------EAHSH
RNDIMLLKLARPVRLTQNVRPVPLPWRCPRPG-QACVVSGWGLVSNNESGT-KG------
-SPESQ------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------FAEDHEKLVQGEPC
NQRSHPYQAALYN----SGQLICGG-VLIHPEWV------LTVAHCKKE-----------
KLHV---------------CLGKHYRRGAEGTQ-SISVAKTVVHPGF--------NPATH
DQDIMLLRLAQPANISERIHALALEENCQASA-TSCHILGWGKTE--EG-----------
-------QFPNSLQ-CAHVQ--------IVPQ-------EACERAYPH-QITRNMVCAGD
PT------HGEDAC---EG---------DSGGP---------LV-CEGL-LRGLV--SWG
EV-PCGSKEKPGVYTDVCRYVNWIRKIIHDHL----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------TPSLALSGSLMAEDSRVLGAQPC
EPHSQPWQAGLLK----DVKLLCGG-VLVAPQWV------LTAAHCQKP-----------
KYTV---------------HLGVQNLQNPESSEQKFKVVKSVPHPCHN-----ESN--GN
SHDLMLLRLRNQS--KTTVKPVGLPSHCPQPA-QKCIVSGWGTTTSPRE-----------
-------NFPDTLQ-CAELK--------IWSQ-------DLCEQAYPG-KISDGMVCAGD
S-------NGVDTC---QG---------DSGGP---------LV-CEGV-LQGIT--SWG
AD-PCGKPDKPGVYAKVCRYTEWIKKIIKAN-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------WTEEQTRLWDGYSC
KVGERPYQVALFY----SNHLLCGG-VLIHPQWV------LTAAHCQKP-----------
SLQV---------------LLGKHNIRRWEQSQQLSPVLKAIPHPAY--------NKVRH
DNDIMLLKLPRARLCLIQPLTLPWESDCMDNSTSPCVISGWGKTX-XXX-----------
-------XXXXXXXXXXXXX-------------------XXXXXXXXX-XXXXXXXXXXX
XX------XXXXXX---XG---------DSGGP---------LV-CQGR-LRGLV--SWG
EV-PCGSTQKPGVYTDVCRYCDWIQRTIQAN-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------MPRPRPGRAGLMWTVLLLLLLLLLA------------------
--SWP---------------------------------------GRTEAQVSKVLQGSEC
EPHSQPWQTALFQ----GERLLCGG-VLVGT-----------------R-----------
KYTV---------------RLGDHSLQSKDEPEQEISVAQSIQHPCYN-----SSNSEDR
NHDLMLIRLRKQASLGPKVQPIDLAKHCAKVG-QKCTISGWGTVTSPRE-----------
-------NFPDTLN-CAEVE--------IFSL-------RKCEEAYPG-QVTDGMVCAGN
S-------NGADTC---QG---------DSGGP---------LV-CDGV-LQGIT--SWG
SD-PCGRPKKPGVYTSICHYRKWIKKTMGNRG----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------MWLLLAFILL-VS--AAQDGDKVLKGEEC
APHSQPWQVALYE----RGRFNCGA-FLISPRWV------LTAAHCQTR-----------
FMRV---------------RLGEHNLRKRDGPEQVRAVSHIIPHPGY--------EARTH
LHDIMLLRLLQPVRLSSQVRPVPLPTRCPFAG-EGCVVSGWGLLSDNKPGA-TG------
-SRKSQVRLPDALH-CANIS--------IISE-------ASCNKDYPG-RVLPTMVCAGV
EG------GGTDSC---EG---------DSGGP---------LV-CSGA-VQGIV--SWG
DV-PCDTTTKPGVYTKVCSYTEWIRENMKTRN----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------MWLLLTFSFLLTSTAAQ-EGDKLLKDEEC
VPHSQPWQVALYE----RGRFNCGA-SLISPHWV------LSAAHCQSR-----------
SMRV---------------RLGEHNLRKRDGPEQLRAVSRVIPHPGY--------EARSH
RHDVMLLRLARPARLTPQVHPVALPTRCPSPG-EVCVVSGWGLVSNNEPGT-TG------
-SPESQVSLPDTLH-CANIS--------IISD-------TSCNKDYPG-HLMSTMVCAGA
ED------GGTDSC---EG---------DSGGP---------LV-CRGV-LQGVV--SWG
DV-PCDTTTKPGVYTKVCHYLEWIREIMKRN-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------MKKLLVVLSLMAAAWAEEQNKLVHGGPC
EKTRHPYQAALYT----SGHLLCGG-VLIHPLWV------LTAAHCKKP-----------
NLQV---------------FLGKHNLRQRESSQEQSSVVRAVIHPGY--------DASTH
DQDIMLLRLAHPAKLSELIQPLPLERDCSANY-TSCHILGWGKTA--DG-----------
-------DFPDTIQ-CAYIH--------LVSL-------DECERAYPG-QITQNMLCAGD
EK------YGKDSC---QG---------DSGGP---------LV-CGDR-LRGLV--SWG
NV-PCGSKEKPGVYTNVCRYTNWIRKTIQAK-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------MGRPRP-RAAKTWMFLLLLGEAWAACGCLDLL--TKLYAENLP
CVHLNPQW-PSQSL---------HCP------RAWRFNPLPPAAGHSRAQEDKVLGGQEC
QPHSQPWQAALFQ----GQQLLCGG-VLIGGNWV------LTAAHCKKP-----------
KYTV---------------RLGDHSLQNKDGPEQEIPVVQSIPHPCYN-----SSDVEDH
NHDLMLLQLRDQASLGSKVKPISLADHCTQPG-QKCTISGWGTVTSPRE-----------
-------NFPDTLN-CAEVK--------IFPQ-------KKCEDAYPG-QITDGMVCAGS
S-------KGADTC---QG---------DSGGP---------LV-CDGA-LQGIT--SWG
SD-PCGRSDKPGVYTNICRYLDWIKKIIGSKG----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------MSLR---------------------------------------------
-----------VLGSG-TWPSAPKMF----LLLTALQVLAIAMTRSQE-DENKIIGGYTC
NRSSQPWQAALLAG--PRRRFLCGG-ALLSDQWV------ITAAHCGRP-----------
ILQV---------------ALGKHNLRRWEATQQVLRVVRQVTHPNY--------NSRTH
DNDLMLLRLQQPARIGRAVRPIEVAQACASPG-TSCRVSGWGTISSPIA-----------
-------RYPASLQ-CVNIN--------ISLDEV-------CQKAYPR-AITPGMVCAGV
PQ------GGKDSC---QG---------DSGGP---------LM-CRGQ-LQGLV--SWG
ME-RCALPGYPGVYTNLCKYRSWIEETMRDK-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------HGQAETRIIKGYECP
AHSQ-PWQVALFQ--NRLHCGATLINRQWLLTAAHCK-P---------------------
-----QYWAHLGVH-NLQQPDN--CEQRRVATISIPHPDFNGSLPNKDHRNDIMLVKLKA
PVRLTRAVQPLPLT-ERCVTPGSQCLISGWGTTTSPQLTLPHTLRCANITIIDHRECE--
GAYPGN-ITDTMVCASVKEAGKDSCQGDSGGPLVCNGTLQGIISWGQDPCAVTRKPGVYT
----KVCKY------VDWVQQTIKDN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------MKKLMVVLSLIAAAWAEEQNKLVHGGPC
DKTSHPYQAALYT----SGHLLCGG-VLIHPLWV------LTAAHCKKP-----------
NLQV---------------FLGKHNLRQRESSQEQSSVVRAVIHPGY--------DAASH
DQDIMLLRLARPAKLSELIQPLPLERDCSA-T-TSCHILGWGKTA--DG-----------
------------------------------------------------------------
----------------------------DSGGP---------LV-CGDH-LRGLV--SWG
NI-PCGSKEKPGVYTNVCRYTNWIQKTIQAK-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------C--------------SVG-LPVALAW-QGWADTRTIGAEECQ
RNSQ-PWQAGLFY-LTRLFCGATLISDRWLLTAAHCRK------P---------------
-----YLWVRLGEH-HLWQWEG--PEQLFRVTDFFPHPGFNEDLSANDHNDDIMLIRLPR
RARLGPAVQPLSLS-QTYLAPGTQCFISGWGAVSSPKVRYPLTLQCANISILDAKLCH--
WAYPGH-ISDSMICAGLWEGGRGSCQGDSGGPLVCNGTLAGVVSGGAEPCSRPRRPTVFT
----SVRHY------VDWIRKTIEEN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------GGPPPLLVPSPAVALLGASLLSWLPVAQRDGDKIIGGYTC
IPHSQPWQAALFAS----RKFHCGG-VLLSNRWV------LTAAHCGHW-----------
NLRV---------------ALGKHNLQRLEPSQQMLRVNRQVVYPRY--------NQRTN
DHDLMLLHLERPVKLTREIQPIQVARNCASPG-TSCLVSGWGTISSPHV-----------
-------RYPSTLQ-CVNID--------ILSDER-------CRNSYPG-AITRGMVCAGD
QK------GEKDSC---QG---------DSGGP---------LV-CNGA-LQGLV--SWG
SE-QCAQAKYPGVYTNLCRYWTWIQNEVRKRQ----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------LSCSPAASQEFSKII------NS-SNGTQSALPGVKECI
PHSQ-PWQAVLLV-NGRLLCGGILIHPSWVLTAAHCLKN---------------------
-----KYTVYLGKH-ALGYSE--AGEQARRVTCSVPHPLYRGIPTHQSHDHDIMLLHLHK
PAQLNNQVQVLPLPSQEYLPPGTCCTVSGWGTTTSPQVNYPKTLQCAEIQLRSDEECH--
QSYPGK-ITPNMLCAGSQEGGKDSCEGDSGGPLVCNGILQGVISWGDFPCGQPNRPGVYT
----RVSRY------VDWIQNVIQTRDPWRKKGME-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------MKLG--------L--------------LCA-LLSLLAG-HGWADTRAIGAEECR
PNSQ-PWQAGLFH-LTRLFCGATLISDRWLLTAAHCRK------P---------------
-----YLWVRLGEH-HLWKWEG--PEQLFRATDFFPHPGFNKDLSANDHNDDIMLIRLPR
QARLSPAVQPLNLS-QTCVSPGTQCLISGWGAVSSPKALFPVTLQCANISILENKLCH--
WAYPGH-ISDSMLCAGLWEGGRGSCQGDSGGPLVCNGTLAGVVSGGAEPCSRPRRPAVYT
----SVCHY------LDWIQEIMES-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------L----SV
LRRGRDSE-GRGLNP---------------V--------------SEEPGACPSP-----
LQAMMILRL-------------------------IM-LALLT-G-HVGGETRIIKGYECS
PHSQ-PWQVALFQ-KTRLLCGATLIAPKWLLTXHLSHLS---------------------
-----RYVVHLGEH-NLQRRDG--CEQTRTATESFPHPDFNNSLPNKDHRNDIMLVKMAT
AAFITRAVRPLTLS-SRCVTPGTRCLISGWGTTSSPQLHLPHTLRCANITIIKHEECE--
TAYPGN-VTDTMVCASVREEGKDSCQGDSGGPLVCDGSLQGIISWGQDPCAVTKKPGVYT
----KVCKY------VDWIQKTMENN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------MSLR---------------------------------------------
-----------VLVSV-TPPPAPRMF----LLLTALQVLAIGMTQSQE-DENKIIGGYTC
IQNSQPWQVALLAG--PGRRFLCGG-ALLSDQWV------ITAAHCARP-----------
ILRV---------------ALGKHNLKRWEATQQVLRVTRQVTHPSY--------NTRAH
DNDLMLLRLERPARLGRAVNTIPIAQSCASPG-TPCRVSGWGTISSPIA-----------
-------RYPTSLQ-CVNIN--------ISQNQT-------CRQAYPG-AITAGMVCAGV
PQ------GGKDSC---QG---------DSGGP---------LV-CQGQ-LQGLV--SWG
ME-RCALPGYPGVYTNLCKYQNWIQETMQGRWRSP-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------MGRPPP-RAALTWMFLLLLGKSWAACGHPGPL--TKLYAENFP
CVHLTPQW-PSQPW---------HCP------RGWRSNPLPPAAGHSRAQENKVLGGQEC
QPHSQPWQAALFQ----GEQLLCGG-VLIGRNWV------VTAAHCKKS-----------
KYTV---------------RLGDHSLQKKDGPEQEIAVAQSIPHPCYN-----SSDVEEH
NHDLMLLQLRDQASLGSKVKPISLADHCIQPG-QKCTISGWGTITSPQE-----------
-------NFPDTLN-CAEVK--------IFPQ-------KECEDAYPG-QITDAMICAGN
S-------NGADTC---QG---------DSGGP---------LV-CDGA-LQGIT--SWG
SD-PCGRPNRPGVYTNICRYLDWIKKIMGNKG----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------MRLA--------F--------------LCA-LLSLLGG-QGWADTRAIGAKECR
PNSQ-PWQAGLFH-LTHLFCGATLISDRWLLTAAHCRK------R---------------
-----YLWVRLGEH-HLWKWEG--PEQLFRATDFFPHPGFNQDLTAQDHNNDIMLVRLPR
KAHLGPAVQPLNLS-QTCVSPGTQCLISGWGAVSSPKVEYPLTLHCANISILEPRLCR--
RAYPGH-ISDSMLCAGLWEGGRGSCQGDSGGPLVCNGTLAGVVSGGSEPCSRPRRPAVYT
----SVCHY------LDWIQETMEDN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------MKLG--------F--------------ICA-LLSVLAG-HGWADTRAVGAQECR
PNSQ-PWQAGLFF-LTRLFCGASLISDRWLLTAAHCRK------P---------------
-----YLWVRLGEH-HLWKWEG--PEQLFRVTDFFPHPGFNEDLSANDHNDDIMLIRLPR
QAQLGPAVQPLNLS-HTCVSPGTQCLISGWGAVSSPKVQYPLTLQCANISILERKLCH--
RAYPGH-ISDSMLCAGLWEGGRGSCQGDSGGPLVCDGTLAGVVSGGAEPCSRPRRPAVYT
----SVCHY------VDWIRKTMEDN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------MSLR---------------------------------------------
-----------VLGSA-TWPSAPKMF----LLLTALQVLAVAMTRSQE-DENKIIGGYTC
ARNSQPWQVALLAG--PGRRFLCGG-ALLSDQWV------ITAAHCGRP-----------
ILRV---------------ALGKHNLKRWEATQQVLRVVRQVTHPNY--------NSRTH
DNDLMLLQLQQPARIGRAIRPIEVAQACASPG-TSCRVSGWGMTSSPIA-----------
-------RYPTSLQ-CVNIN--------ISPDEV-------CRKAYSG-AIKPGMVCAGV
PQ------GGKDSC---QG---------DSGGP---------LV-CKGK-LQGLV--SWG
ME-RCALPGYPGVYTNLCKYRSWIEETMRGK-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----MW---PLALV-IASLTAALSGGISQESSKIL------N--NNGTSGFLPGGYTCF
PHSQ-PWQAALLV-QGRLLCGGVLVHPKWVLTAAHCLKE---------------------
-----GLKVYLGKH-ALGRVE--AGEQVREVVRSVPHPEYRSSPTHLNHDHDIMLLELQS
PVQLTGYIQTLPLSHNNRTTPGASCRVSGWGTTTSPQVSYPKTLQCANIQLRSDEECH--
QVYPGK-ITANMLCAGTKEGGKDSCEGDSGGPLVCNRTLHGIISWGDFPCGQPDRPGVYT
----RVSRY------IVWIRETIRKYEIQ-QQWTKGPK----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------CSRAQEPKVLQGHEC
EPHSQPWQVGLFQ----STQLLCGG-VLIDDYWV------ITAAHCKKP-----------
KYTV---------------RLGEHSLQSEDSQEQEVAVARSIPHPCYN-----SS-SENH
SHDLMLIRLRRRPNLGSKVKPIELADQCPQAG-QNCTISGWGTISSPRE-----------
-------SFPDTLI-CAEIK--------IFPQ-------KRCEDAYPG-KVTDGMVCAGH
S-------NGADTC---QG---------DSGGP---------LV-CNGV-LQGIT--SWG
SD-PCGQPERPGVYTNLCRYRDWIRKTIGKTG----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------MKLG--------F--------------ICA-LLSLLAG-HCWAGIRAIGAQECR
PNSQ-PWQAGLFY-LTRLFCGATLISDRWLLTAAHCRK------P---------------
-----YLWVRLGEH-HLWKWEG--PEQLFRATDFFPHPGFNSDLSANDHNDDIMLIRLPR
QAQLSSAVQPLNLS-QTCVSPGTQCLISGWGAVSSPKAQYPVTLQCANISILENRLCR--
WAYPGH-ISDSMLCAGLWEGGRGSCQGDSGGPLVCDGTLAGVVSGGSEPCSRPRRPAVYT
----SVCHY------GDWIRKTMQDN----------------------------------
------------------------------------------------------------
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------------------------

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-----KGRG--------LC--------------CSP-LWFLSPR-HSWADTRAIGAKECP
RNSQ-PWQAGLFF-LTRLFCGATLISDRWLLTAAHCRK------S---------------
-----RLWVRLGEH-HLWQWEG--PEQLFLARDFFPHPGFNSDLSANDHNHDIMLIRLPR
RARLGPAVQPLNIS-KTCISPGTKCLISGWGAVSSPKAQFPLTLQCANINILEPTLCH--
WAYPGH-ISDTMICAGQWEGGRGSCQGDSGGPLVCNGTLAGVVSGGGEPCSRPQRPAVYT
----GTCHY------YDWIKKTMEEN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------

------------------------------------------------------------
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-----MW---PLALV-IASLTLALSGGVSQESSKVL------N--TNGTSGFLPGGYTCF
PHSQ-PWQAALLV-QGRLLCGGVLVHPKWVLTAAHCLKE---------------------
-----GLRVYLGKH-ALGHVE--AGEQVREVVHSIPHPEYRRSPTHLNHDHDIMLLELQS
PVQLTGYIQTLPLSHNNRLTPGTTCRVSGWGTTTSPQVNYPKTLQCANIQLRSDEECR--
HVYPGK-ITDNMLCAGTKEGGKDSCEGDSGGPLVCNRTLYGIVSWGDFPCGQPDRPGVYT
----RVSRY------VLWIRETIRKYETQQQKWLKGPQ----------------------
------------------------------------------------------------
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------------------------

------------------------------------------------------------
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-----MW---PLALV-IASLTVALSGGISQESSKIL------N--NNGTSGFLPGGYTCF
PHSQ-PWQAALLV-QGRLLCGGVLVHPKWVLTAAHCLKE---------------------
-----GLKVYLGKH-ALGRVE--AGEQVREVVRSVPHPEYRSSPTHLNHDHDIMLLELQS
PVQLTGYIQTLPLSHNNCITPGTTCRVSGWGTTTSPQVSYPKTLQCANIQLRSDEECH--
QVYPGK-ITANMLCAGTKEGGKDSCEGDSGGPLVCNRTLHGIISWGDFPCGQPDRPGVYT
----RVSRY------ILWIRETIQKYETQQQKWTKGPK----------------------
------------------------------------------------------------
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------------------------

------------------------------------------------------------
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-----MW---SLAAI-MACLTLALSGGISRDYPKIL------NG-TNGTSGFLPGGYTCL
PHSQ-PWQAALLV-RGRLLCGGVLVHARWVLTAAHCRKE---------------------
-----GYTVHLGKH-ALGRTE--RGEQVREVVRSIPHPEYQVSPTHLNHDHDIMLLELRD
PVQLTGQVRVLPLSRDPCLPVGTCCRVSGWGTTTSPQVSYPKTLQCANIELRSDEECR--
QVYPGK-ITANMLCAGTKEGGKDSCEGDSGGPLVCNHTLHGIISWGDFPCGQPNRPGVYT
----RVSKY------VDWILRTIQKHQPQKQRWTKGPQ----------------------
------------------------------------------------------------
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------------------------

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------------------------MF----LLLAALHILAGARAQSPVDDDHRIIGGYEC
NKNSQPWQAALLAG--PGRRFLCGG-SLLSDKWV------LTAAHCARP-----------
ILHV---------------ALGKHNLRRWEATQQIRRVVRQVPHPQY--------NPRTH
DNDLMLLQLQRAVPLGRAVRPIALASACASPG-TPCRVSGWGTTSSPIA-----------
-------NFPPTLR-CADIS--------VFPEQT-------CRQAYSG-AITPNMVCAGV
PQ------GGKDSC---QG---------DSGGP---------LV-CGGQ-LQGLV--SWG
ME-RCAMRGYPGVYTNLCKHIGWIQTTLRGP-----------------------------
------------------------------------------------------------
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------------------------

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-------------------------------MWLLLIFSFLLTSAAAQEDDGKVLRGEEC
VPHSQPWQVALFE----RGRFNCGA-SLISPYWV------LSAAHCQTR-----------
NMRV---------------RLGEHNLRKRDGPEQLRAVSRFIPHPRY--------EARSH
RHDVMLVRLQRPARLSPQVRPVALPARCPHPG-EACVVSGWGLVSDNEPGT-TG------
-SPESQVNLPDTLH-CANIS--------IIST-------ASCDKDYPG-RLMDTMVCAGV
EG------GGTDSC---EX---------XXXXX---------XV-CGG--VQGIV--SWG
DV-PCDTTTK-GVYTKVCSYLEWIRDTMRRN-----------------------------
------------------------------------------------------------
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------------------------

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--------------------------------MKKLMVVLSLIAAAWAEEQNKLVHGGPC
DKTSHPYQAALYT----SGHLLCGG-VLIHPLWV------LTAAHCKKP-----------
NLQV---------------FLGKHNLRQRESSQEQSSVVRAVIHPGY--------DAATH
DQDIMLLRLARPAKLSELIQPLPLERDCSANT-TSCHILGWGKTA--DG-----------
-------DFPDTIQ-CAYIH--------LVPR-------EECEHAYPG-QITQNMLCAGD
EK------YGKDSC---PI---------GTSWP---------GN-VPQG-AVGGY--NSG
LV-PRAQEEAVA-------------RKVQA------------------------------
------------------------------------------------------------
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------------------------

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------------------------MF----LLLTVLQALALAMVQSQG--DHKIIGGYTC
IQNSQPWQVALQAG--PGRRFLCGG-VLLSDEWV------ITAAHCARP-----------
ILHV---------------ALGKHNLRRWEATQQVVRVARQVPHPQY--------QPRAH
NNDLMLLKLQKKVRMGRAVKAIALATSCASPG-TPCRVSGWGTTASPVA-----------
-------RYPNALQ-CVNVN--------IMSEEV-------CRRAYPG-TITSGMVCAGV
PQ------GGKDSC---QG---------DSGGP---------LV-CGEQ-LQGLV--SWG
ME-RCAMPGYPGVYANLCNYQNWIQRTMQGN-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
-----MW---PLALV-VASLTVALSGGVSQESSKVL------N--TNGTSGFLPGGYTCF
PHSQ-PWQAALLV-RGRLLCGGVLVHPKWVLTAAHCLKE---------------------
-----GLKVYLGKH-ALGRVE--AGEQVREVVYSIPHPEYRRSPTHLNHDHDIMLLELQS
PVQLTGYIQTLSLSHNNRLTPGTTCRVSGWGTTTSPQVNYPKTLQCANIQLRSDEECR--
QVYPGK-ITDNMLCAGTKEGGKDSCEGDSGGPLVCNRTLYGIISWGDFPCGQPDRPGVYT
----RVSRY------VLWIRETIRKYETQQQKWLKGPQ----------------------
------------------------------------------------------------
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------------------------

Query Results

"ENSGT00760000118862_0"

ENSGT00760000118862_0