ENSGT00760000118824_0 : Linker Region Query Results

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-----------------------------------------------------MSEQSKD
VCD---------------------------------------------------------
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--------PNF----------------------------A---------------ADA-S
HSEV--------------------------HSS-----------------PGVAGG---P
S--PPASQAAT----------LAGPEIPPVGP------------P---------------
----DAPLAS--------------------------------------------------
------PPP--------------QALSEEGD---------PKAL-QQA-A-EE--GR---
----------------------AHQAR----STAQPS-PAPPAPAQLVQKAHELM-----
-------WYVLVKDQKRMIIW-FPDMV--KDVIGSYK-----KWCRSILRRTSLI-----
----LARVFGLH---------LRL-TSLHT---------MEFS-----------------
-------L----------------------------------VKALAPEELD-----RVA
----LSNRMPMTGLL-------LMILSLIYVKGRG------ARES---AVWNVLRIL---
-----GLR-PWK----KHSTFGDVRKLITEEFVQQ------NYLKYQRV-PHVEPPEYEF
----FWGSRASREIT--KMQIMEFLARVFKKDPQ----A-WPSRYRE---ALEEARALRE
ANPTA----------------------------------HCPRNSVSED-----------
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-------------------------ML--EVVTESYK-----NEFPVIFNKASKC-----
----LQMIFGID---------VKE-VDPTG---------HSYV-----------------
-------L----------------------------------VNSLDL-TYS----EVLS
----DNQSMPKNGLL-------ITILGVIFIEGNC------ASEE---SIWEFLNMM---
-----GLY-AGE----EHFIYGDPRKLLTVDWVRE------NYLEYQQV-PLSDPPLYEF
----LWGPRARAETS--KMKVLEFLAKVKGSDAI----A-FSDWYEE---ALRDEEERAR
ARID-PMDRAT-SPSPS-------------------------------------------
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------------------------------MPR---------------------------
----------------------GNKSK---------------------------------
-SR-----------------SRAKRQ-QMRGEKPK---LQGAQPTGKEEGK------AA-
-SP-------------------ALD-QGD-GPSSSDRGTAQESQ-E-------------A
---------ASHI---S-------------PELNVSHPVHDVG---------AEG SFAGV
DERRANVSIIADAIQ-CARRDPL---TRKASKVLH------YLLEKY-QKDEQP--VE--
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----GEM---L KLIGRKYKVHFPQILEKATYQLELVYGLELKVDNPATHSYV-LVSKLPI
LPGADV-GGRREL-PKTG---LIL----------TILGM----------IF--------M
-KGNR----A-T--EEEVWQFLHMQGIY--PGRRHLIFGEPRNFITKVLVEQN-------
---------YVEYRQVPGSDP---P--THEFLWGPRAHEESTYRKVMDILAKIKSA---I
------PSYYPQQYEETLSNQAERAARRDE-AGGFHAA---RIPS----HAQASSSSHI-
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--------------------------------------MPRGQK---SKLRSREKR-RQA
-RS-----EIQRL-----------------------------------------------
-QG-------------AQATAAEE------------------------------------
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-DTV-------------------------SSSR---------------------------
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------------------------QRSNGGA---------------QS-Q-DG-ERA---
-----------------------------ST-SQALSTTDSSFTTRLDQKAVLLV-----
-------QFMLRKYNKRELIT-KKDLL--KYVTKKYK-----MHFDEILRKAAEL-----
----MVLAFGID---------VQE-VDSAK---------HYYA-----------------
-------L----------------------------------VRQLDH-TGD----PRMN
----G-EIMPRSGLL-------MTILCVIFIKGNS------APEE---DIWEVLNVM---
-----GIY-AGE----NHFIHGEPKKLITQDLVQE------RYLEYRQV-LNSDPPCYEF
----LWGPRAHAETS--KMKVLEFLAKMHNTVPT----A-FPAWYED---AVIDEEERMR
SR-FAA------------------------------------------------------
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---------------------------------------------REVRP--GLRGIELV
QKKRVS---QSMPGVEVMTIRLSPLCLLSCPVPPIRVIMSQN-Q----------------
-----------------ESP-LCTHE-Q----------------CLQA----HYE-TQG-
-------------LEFTQVLDTAE------------------------------------
-----------------------------------------------------------E
V-----------------------------------------------------------
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---SSLCSLSLI----SCT--LEDA---S---------------------VPG-------
----------E--------------------------------------PKN--------
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------------------------------------------------HKVDLLA-----
-------NLLLLKYQLNEPIT-KADML--TSVIKKYK-----DHFPEILRRTTDC-----
----MELLFGID---------VKE-VDPKS---------HCYL-----------------
-------L----------------------------------VNKLDL-TYD----GRLS
---GD-DGMPKTGLL-------ILILGVIFMKGNC------ATEE---EVWEVMNMM---
-----NIY-SGR----KHFLFGEPRKIITGNFVKE------KYLEYRQV-PNSDLPCYEF
----LWGPRAQAEAN--KMKLLEFLAKIHGTSPR----C-FLSQYEE---ALKDEQERGQ
ARIADKAGTTT-------------------------------------------------
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-----------------------LA--------T----------------ASS----TA-
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---------MFT---------------------SFSQ-----------------------
------------------P-----------------------------------------
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--------------------------------------MP--------------------
---------LFPSVL------FPNFE-E----------------DSQY----PVV-IED-
-------------W----------------------------------------------
-------------------------------------------------IDAQDP--TDE
EEEEAS----------------------SISS-STFYLV-FSPSSFS-------------
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------SSSSLI----LGG--PEE-VVP----------------SDVIPSLPESTP---S
S----PP------------------------------------------QSPP---QGPS
QSPQSSCC--------S-S--FSWSSFSE----------------ESSSQ-KEED-T---
------------S------TCQGL------------PDSESSFTHTLDEKVAELV-----
-------AFLLLRYKAEEPVT-EAEML--MIVI-KYK-----DYFPVILKRAREF-----
----MELLFGLA---------LIE-VGPD----------HFSV-----------------
-------F----------------------------------ANTVDL-TDE----GS--
---DD-EGMPENSLL-------IIILSVIFIKGSF------ASEE---VIWEVLNAI---
-----GVY-AGR----EHFIYGEPRELLTKVWVQG------QYLECREV-PNSSPPYYEF
----LWGPRAHSESI--KRKVLEFLAKLNNTVPS----S-FPSWYKD---ALKDVEERAQ
AMTDTTDDA-T-------------------------------------------------
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-----------------------VM------ATE----------------SLS--V----
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---------MSS---------------------NLPF-----------------------
------------------SE----------------------------------------
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---------------------------------------MSDP-----------------
---------------SE-SGA----------------------------GPTHLKAKASE
KGGS-LMKQTLL-------KASQ--DKEGSEAPKAT------------------KA----
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--------PEVSEAAKSS-------KASGVS---------------KAT-----------
-------------EV---------------------------SKAPEDPEAA-TTKASSA
-TQKTKTQIPAA----ES--KSAAADT--KEQKADLQ-------AVKVPAT---------
----QTKK-----VSC--------------------------------------------
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--------------------------------------------------------MA--
-------------------------------DPKV-------------------------
----S-T--KALDTEA--------SASQAWAD-D---------EPESKGAAVQVQENQDT
RPKDK--------------------V---------------------------------K
KARKVKHLEGEEDAN---------------SDQSQASGSPSGRRVSKALMASMARRASRG
PIAFWARRAS----RTRLA----A------------------------------------
------------------------------------WARRALL----SLRSPKTRRGKAR
CKS---------------------------------------------------------
-GKLQS-PQDPEAPP-PRDVALL---QGRANDLVK------YLLAKD-QTKIPI--KR--
------------------------------------------------------------
----EDM---LKDIIKEYTDVYPEIIERAGYSLEKVFGIQLKEIDKSDHLYI-LLSTLEP
TDAGIL-GTTKDS-PKLG---LLM----------VLLSI----------IF--------M
-NGNR----S-N--EAVIWEVLRKLGLR--PGIHHSLFGDVKKLITDEFVKQK-------
---------YLDYARVPNSNP---P--EYEFFWGLRSYYETSKMKVLKFACKVQKK---D
------PKEWAAQYREAMEADLKAAAEAAA--EAKAR----AEIRAQMGIGLGSE-----
----NAAGP--CNWD-------------EADIGPWA-KARIQAGAETKAQAQENG--SAS
AGASTSA--------GASTSASAGASA--SGGFSSSASLTATLTFGLFAGLGGAGASTSG
SSGACG-FSYK-------------------------------------------------
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--------------------------------------MPRP-R----------------
-----------------KRR-RCMVE-G----------------QPEG----QNE-TEG-
-------------QMSVAVSTE-E------------------------------------
-----------------------------------------------------------D
S-SS-------------------------SSTSSSSFPFSFSST----------------
-----------------------------------------------------------S
------SSYSQT----SGN--SEEG--C--------------------------------
----------A--------------------------------------ASRA---F---
-------S---SCTAMV-S--SPCSQVS-------------------ADP-EGEESP---
------------G------SSQTLL------------CGASLSTGEIDVKVDELV-----
-------KYLLFKYLMKEPVS-KAEIL--SNIIKNYQ-----DHFPVIFREASEC-----
----MQLVFGLE---------LKE-IDPAG---------HTYI-----------------
-------L----------------------------------AIALEL-TYD----GMMT
---DI-QGIPKTGLL-------IMVLSIIFMEGNC------IRED---MVWGVLNNI---
-----GLY-AGS----EHFIYGEPRKLITDDFVQE------GYLEYRQV-PGSHPPSYEF
----LWGPRAYAETT--KMKILTFLTSINGSDPR----S-YPVWYAE---ALRDEEERE-
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-------------------------------MPE----L-L-MHYHF-----------LS
F-RCPKHM-------LFCPDTCLLSQTTVIMPQ---------------------------
----------------------SKKNK-------------------------------PL
--------------------TPKKAS-HVQREAPR---LQEAQA--SKKKILP-SSSPP-
----------------------LGIISHT-KSTYQSRCPPKRSQ-R-------------A
---------V-ST---T-------------MSSDISTPRSDKG-------------ATCK
SKKKQHSSQPPKSII-QIPRDVL---TKMASRLVN------FIIRKY-KMKRLI--SK--
------------------------------------------------------------
----EGM---LKIIYKKYKNHFLEILRKASFNIEVVFGMDLKETDAISHSYT-LVDKMNL
PYNGKL-SRGRGF-PKTG---LLM----------NLLGV----------IF--------M
-KGNS----V-T--EEKIWEFLNKMRIY--DGQRHFLFGEPRKLITGDLVKLR-------
---------YLEYRQVPDSDP---P--LYEFLWGPRAYAETSKMKVLEFWAKINDT---T
------PTAFQGRYEEALRDEEERAKK---------------------------------
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--------------------------------------MSHSR-----------------
-----------------KRR-CFMLE-A----------------DPEA----QDD-NQG-
-------------HA---------------------------------------------
--------------------------------------------------------DTEE
EDSSLSSSN-----------------------CSSSFPS---------------------
---SSH---------------------------------------T----------SFSS
S-SFSGS-PPHL----SSS----EED----------------------------------
---------DT--------------------------------------AAGD---PVSP
ESPLGAYA---SLPAMV-S--APWSSSDA----------------CSVSS-PCGG-V---
------------N------ACQVLP------------GYQILPSGEGDNRVTNLV-----
-------NLLLFKYRMKELVT-EAEIL--NVI--QNY-----SDYAAIFSEVYEC-----
----MQLVFGIE---------LKD-VEPSN---------HAYV-----------------
-------L----------------------------------VSVLGI-SYD----GM--
LS-EV-QGVPKTGLL-------VLLLCTIFLRGGR------VPAE---DIWHMLNVM---
-----GIW-SGA----THFIYADPRNLILGDFLQE------QYLVYQQV-PNSCPARYEF
----LWGPRVCAETS--KMKIIEFLASLSGSDPK----S-FGARYEE---ALREEEERMQ
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-----------------------------------------MP-----------------
-----------------YYP-YFSLE-K----------------VFQD----AFE-IYI-
-------------LPDEEQEDDEEEMEEEGEEIEEEEEEMEEEEEEEEEEGEEE------
---DYDDEEEEEG----TGEE----------------EEIEVEEVEEELEEEEIEGDVEE
VEEEEEVEQ------EEYEEDIEEEEWETIDGDTVSFTLSATLKISL-------------
---PSC---------------------------------------------------PSP
PSTFSS--HPLI----WGN--PNGMEESV-------------------------------
-----AWMM------------------------------------------------NIS
QSHQSLYT----------F--TSCSNLDE----------------EYSSQ-EEES-----
-------------------------------------LNTFSWRKRQNQKVTELV-----
-------NLLILKYRKKEPIK-KVEML--TVVTEDYE-----NQFPIIFEEASKC-----
----LEMIFGID---------IKE-NDAVS---------SSYV-----------------
-------L----------------------------------TNTLGL-TYE----DT--
MT-DN-QRLPRNGFL-------IVILGVIFIEGNC------ASEE---SMWEFLNMM---
-----GIY-DGK----EHFIYGEPREFLTIDLVHQ------NYLKYQQV-PKSYPPRYQF
----LWGPRAYSETT--KMKVLEFLAKLTSRAPT----H-FSSLYSE---AFRDEEGRAG
I-----------------------------------------------------------
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------------------MSQ--LSKNLGDSSPPAEAPKPP-------------------
----------VYSRPTVLMRAP-----PASSRAPPVPWDPPPIDLQA-SLAAWQAPQPAW
EAPQGQLPAPV---VPMTQPPALGGPIVPAPPLGGPMGKPPT------------------
---------------PGVLMVHP-PPPGAPMAQPPTPGVLMVHPSAPGAPMAHPPP-PGT
PMSHPP-------------------------PPGTPMAH---------------------
-----P---------P------------------PPGTPM----A-------HPAPPGTP
------------------------MAHP--PPPGTPMVHPPPPGTPMVHPPPPGTPMAHP
PPPGTP--MA-------------------QPPPPGTPMAQP---PAPGVLMAQPLTPGVL
MVQPA-------------APGAPMVQPP----PAAVM-------------------TQPP
PSGAPMAKPPGPGVLMIHPPGARAPMTQPPASG---------------APMAQPTAPPAQ
PMAPPAQPMASWAPQAQPVILQIQSQVI----R-------APPQV---P-----------
-------Q---GPQAPPAQLATPPGWQATSPGWQATPQGWQATPLTWQTTQVTWQAPA--
----------ITWQVPPPV-RQGPPPIRP-------------GPPPIRPGPPPVR---QA
PPVIRQ---APPVIRQA--------PPVIRQAPPVLRQAPPVLRQAPPVIRQAPPVLRQA
-PP---------V-----------------------------------------------
--------IRQAPPLIRQAPP-PI------------------------------------
-----------------------------------------------------------R
--------------PAPQVLATQPPLWQALPPPP-----P---------------LRQAP
QARLPAPQVQA------------APQVPTAPPATQ-------VPAAPLAGPQVPQP---V
L--PAPLSAP----------------------------------------LSA-------
----------P-----------QAVH--CPSIIWQAPKGQPPVPHE--------------
------------------------------------------------------------
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---------IPTSMEFQEVQQ-TQ-AL--AWQAQKAP-----THFWQPLPAQEAQRQ---
----APPMVQLE-------QPFQGAPPCQKAVQIQL-PPQPPQTS--GPQAELPTLQLQP
SWQTPPAVLQAQPGPPLAAANFPLGSAKSLMTP-SGESRASSIDRRGSS-KE----RRTS
SK--ERRAPSKDRM----------IFAATFCAPKA----VSAARAHLPGAWKNLPATPET
FAPSSSVF-PAT----SQFQPASLNAFKGPSAASE----APKSLPYAL---QDPFACAEA
LPAVPWAPQPNMNASKASQAVPTLLM-ATAAAPQ----A-TATT-QE---ASKTSVEMPR
RS-----------------------GKA--------------------------------
--TRK-----KKHLEARE-DSRGHTLA-------------------------------FH
--D-WQGP----RPWENLN--LSDW--EVQSPVQ-V--LGDWEHPNTPRGLSGWEGPSTS
-RI---------------LSG---WEGPSTSWALSAWEGPSTSR-A--------------
---------LGLS---------------ESPRSPLPLVVSEVA-------------G---
VSPGSSATQDNSKVE-AQSLSPL---DERANALVQ------FLLVKD-QAKVPV--QR--
------------------------------------------------------------
----SEM---VKVIIREYKDECLDIINRANNKLECAFGYQLKEIDTQNHAYI-IINKLGY
PTGDLV-ASYLDR-PKFG---LLM----------VVLSL----------IF--------M
-KGNC----V-R--EDLIFNFLFRLGLD--VRETNGLFGNTRKLITEVFVRQK-------
---------YLEHRRIPYTEP---A--EYEFLWGPRAFLETSKMLVLRFLAKLHKK---D
------PRCWPFHYLEALAECEWEDTDEDE-PDS--SDSDSA-------RGP--------
---TSRPPPR--------------------------------------------------
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--------------------------------------MSLSQMN---------------
-----------------ELS---KQG-E----------------DDVD----PGE-RQG-
-------------LLEERVLGTEE------------------------------------
-----------------------------------------------------------E
EA----LS----------------------------------------------------
------------------------------------------------------------
------SFSSAL----SDS--LEE------------------------------------
---------VA--------------------------------------AGVA---SSPP
QSPEGACP---SPAARE-A--VPLSQPKE----------------ECPSN-EDEGAP---
------------G------RTP--------------DAESSQK-EAPHLKMGDLV-----
-------VFLLLKYRTKEPAT-RSEML--SRVNKEHQ-----DHFPEILSRASRC-----
----LRLLFGIE---------VEE-VDPSN---------NIYF-----------------
-------L----------------------------------GTTLGL-TYD----GT--
--------IPNTGLL-------VTFLCLILLEGDC------APEE---EVWKSLNVM---
-----GLY-DGR----EHCIYGEPRELITRVWVRE------QYVVYRQV-ANSDPARYEF
----LWGPRAHAETS--KLKVLEYLLNLKREPLP----E-VAQRHEE---EE--------
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--------------------------------------MPRGQK---STLRAREKC-QQT
-WG-----QIQGH-----------------------------------------------
-QG-------------AQMTATQK------------------------------------
-----------------------------------------------------------K
-KVS-------------------------FSCPL-----I---------------LGATI
QKKS-A------------------------GRSGS-------V-------LKKPQR---A
L--STT-TSV-D------------------------------------------------
------------------------------------------------------------
-----------------VY----HKKSYKGA---------------NS-K-IE-KKQ---
-----------------------------SF-SQGLSSTVRSRTDPLTIKTNMLV-----
-------QFLMEMYKMKKPIM-KADML--KIVQKRHE-----NHFPEILKKASFN-----
----MEVVFGVD---------LKK-VDSTK---------DSYV-----------------
-------L----------------------------------VSKMDL-PNN----GTVT
----RGRGFPKTGLL-------LNLLGVIFMKGNC------ATEE---KIWEFLNKM---
-----RIY-DGK----KHFIFGEPRKLITQDLVKL------KYLEYRQV-PNSDPACYEF
----LWGPRAHAETS--KMKVLEFWAKVNQTVPS----A-FQFWYEE---ALRDEEERVQ
AA-ATFNDGSS-AM----------------------------------------------
----------------------------------------------------------GR
--------------------KCSKVK-----------------------ASS---SSHA-
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---------------------------------------MSDT-----------------
---------------SE-SGA----------------------------GPACFQAKASE
KDSG-SVMQTLL-------IVTQ--NLEVSETPKAS------------------KA----
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--------PEISETTKVS-------KALGVL---------------KAM-----------
-------------KV---------------------------SKAPKAQEAP-AIQSSPA
-KQLTDTQGLTA----ES--KSPAADT--KTQNTDLR-------A--VPAT---------
----EAKK-----VSC--------------------------------------------
------------------------------------------------------------
--------------------------------------------------------VA--
-------------------------------DMKV-------------------------
----N-T--KASEKEA--------AASQPQADE-----------PEHEGAAAQAQENQDT
RPKVK--------------------A---------------------------------K
KARKVKHLEGEEDGS---------------SEQSQTSGTTGGRRVSKALMASMAKRASRG
PIAFWARRAS----RTRLA----A------------------------------------
------------------------------------WARRALL----SLRSPKARRGKAR
RRA---------------------------------------------------------
-AKLQS-SQEPETPP-PRDVALL---QGRANDLVK------YLLAKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LKDIIKEYTDVYPEIIERAGYSLEKVFGIQLKEIDKNDHLYI-LLSTLEP
TDAGIL-GTTKDS-PKLG---LLM----------VLLSI----------IF--------M
-NGNR----S-S--EAVIWEVLRKLGLR--PGIHHSLFGDVKKLITDEFVKQK-------
---------YLDYARVPNSNP---P--EYEFFWGLRSYYETSKMKVLKFACKVQKK---D
------PKEWAAQYREAMEADLKAAAEAAA--EAKAR----AEIRARMGIGLGSE-----
----NAAGP--CNWD-------------EADIGPWA-KARIQAGAEDKAKAQESG--GAS
ASA--ST------G----TSASAGASA--SGGFSANTSLTATLTFGLFAGLGGAGASTSG
SSGACG-FSYK-------------------------------------------------
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--------------------------------------MPRGLK---SKLRAREKR-RQA
-RE-----EPSGL-----------------------------------------------
-VE-------------AQAAAPEE------------------------------------
-----------------------------------------------------------E
-ESA-------------------------SSPSA-----H---------------FKDVP
QSSP-T------------------------TGTPS-------S-------LQVSAR---V
R--SATMTAA-G------------------------------------------------
------------------------------------------------------------
-----------------VS----NTRFNEGA---------------TN-Q-RE-ERA---
-----------------------------NA-IQAQDALEHWPKGPIDKKVAMLV-----
-------HYLLYKYQMKEPVT-KADML--RNVIQMYK-----NHFYEILRKASDH-----
----LELVFGLD---------VKE-VDPNR---------NTYV-----------------
-------L----------------------------------VNKLEL-SYD----SKLS
----DDREVPKTGLL-------MTVLGVIFTKGNR------ATEE---QVWEVLNMM---
-----GLY-AGR----NNFIYGEPRKLITKDLVQE------NYLEYRQV-PDSDPPRYEF
----LWGPRAHAETS--KMKVLEFVAKIHDTVPT----A-FPTWYEE---ALRDEEERAR
AR-AAARARTA-AI----------------------------------------------
----------------------------------------------------------AS
--------------------ARS--K-----------------------AIAS-SFSGPK
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-----------------------E-LEPKS---------HTYI-----------------
-------L----------------------------------VTPLEPVEED----AEVR
----GDQGTPTTGLL-------MTLLGLIFMKGNA------VKET---EVWDFLRRL---
-----GVH-PTK----KHLIFGDPKKLITEDFVRQ------RYLDYRRI-PHTDPVDYEF
----QWGPRTSLETS--KMKVLKFVAKVHNQDPK----D-WPAQYCE---ALADEEARRG
PRPG-GPALP--------------------------------------------------
------------------------------------------------------------
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------------------------------------------

------------------------------------------------------------
------------------MSL--VSQNSRRRRRRGAK---ATA-----------------
----------H-NS---EIQAPNAPGLPGDVPGSDVPQGPIDSQILQ-GLCAS-------
---EG-----------------PST------------SVLPT------------------
---------------SAEGPST---------FVPPTIS---EASSASGQPTV-SEG-TGT
SVLPTP---------------C-EG----LSTSGPPTMS---------------------
-----KGLCTSVTLAASEGQN------TSRPPTSSKKPST---SL-------PPTVSERR
-S----------------------TSVPPTPGEGTSTSVPPTA--------FEGPSTSVA
STLAEGPSTS-------------------VPPNPGEEASTS-------VP--LTATEGLN
ISVPATPDEGLS--------TS---VL-----P---TR------------LST---SVLP
T------VPEGLSTSVPSTPNEGPSTSVLPAAS---------------DKQSTS------
------------------------------------------------------------
------------------------------------------LVPTLSKGSSTSVLPTTT
EGLRTSV---------QPTPGEGLSTSVP---------------PIATEGPST-------
-------------------------------------------------------SNTSV
----------PPT----------------------------------------------A
SEGLSTS---------MATP-G--------------------------------------
-----------------------------------------------------------E
GPST------------------------SVLLTP-----T---------------PGEGT
ST-SVPP-TPG------E-----------------G--L---A-TVP---PI-PGE----
G--PSTLVQP----------------TSSNGP--------------GSSVLPTP------
---GEGPSTLFSSNA-----SMDRNPSKCS-VVLPSPGESKA------------------
----------------S------VDSDSEGP---------------K-------------
-------GAEGPIEFQVLRDCESPNSITIMGLSTSRVAITLKPQDPIEQNVAELL-----
-------QFLLVKDQSKYPIR-ESEMR--EYIVKEYR-----NQFPEILRRAAAH-----
----LECIFRFE---------LRE-LDPEA---------HTYI-----------------
-------L----------------------------------LNKLGPVPFE-----GLE
----ESPNGPKMGLL-------MMILGQIFLNGNQ------AKEA---EIWEMLWRM---
-----GVQ-RER----RLSIFGNPKRLLSVEFVWQ------RYLDYRPV-TDCKPVEYEF
----FWGPRSHIETT--KMKILKFMAKIYNKDPM----D-WPEQYNE---ALEEDAARAF
AEG---------------------------------------------------------
------------------------------------------------------------
----WQALPHFRRPFFEE----------VAGE------------------VAS-PD----
-SE---------------------------------------------------------
---------VSNY-------------------------S---------------------
---------SKYPPH-SWPESRL---ESKARKLVQ------LFLLMD-STKLPI--PK--
------------------------------------------------------------
----KGI---LYYIGRECSKVFPDLLNRAARTLNHVYGTELVVLDPRNHSYT-LYNRREM
EETEEI-VDSPNR-PGNN---FLM----------QVLSF----------IF--------I
-MGNH----A-R--ESAVWAFLRGLGVQ--SGRKHVI--------TCRYLSQR-------
---------YIDSLRVPDSDP---V--QYEFVWGPRARLETSKMKALRYVARIHRK---E
------PQDWPQQYREAMEDEANRADVGHR-QF----------FVHNFR-----------
------------------------------------------------------------
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-----------------------------------------------------MSEQSKD
VCN---------------------------------------------------------
------------------------------------------------------------
--------PNF----------------------------A---------------AEA-S
NSEV--------------------------HSS-----------------PGIPGE---P
S--SPGSQAAT----------LTESESPPLSP------------P---------------
----DAPLVS--------------------------------------------------
------LPP--------------QAPGEEGD---------PKAL-QQA-A-EE--GR---
----------------------PHQAP----STTQLS-PAPPAPAQLVQKAHELM-----
-------WYVLVKDQKRMIIW-FPDMV--KDVIGSYK-----KWCRSILRRTSLI-----
----LARVFGLH---------LRL-TSLHT---------MEFS-----------------
-------L----------------------------------VKALEPEELD-----RVA
----LSNRMPMTGLL-------LMILSLIYVKGRG------ARES---AVWNVLRIL---
-----GLR-PWK----KHSTFGDVRKLITEEFVQQ------NYLKYQRV-PHVEPPEYEF
----FWGSRASREIT--KMQIMEFLARVFKKTPQ----A-WPSRYRE---ALEEARALRA
AHPTA----------------------------------HCPRNSVSED-----------
------------------------------------------------------------
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--------------------------------------MPRGQK---SKLRAREKR-RRN
-RG-----ETQGL-----------------------------------------------
-NA-------------Q-ATTAGE------------------------------------
-----------------------------------------------------------E
-ETT-------------------------SSSSP-----A---------------PGDAP
SSSS-V-------------------------AGT----------------PHGPQK---A
P--AT-TSAAAG------------------------------------------------
------------------------------------------------------------
-----------------VT----RSRSEVGA---------------KG-Q-VE-ESK---
-----------------------------NS-TQASTSSESSHKDPLTRKVGMLV-----
-------QFMLFKYKMKDPIK-KAEML--KIINKRYR-----EHFPEIFRRASER-----
----MELVFGLK---------LKE-VKPNS---------HSYI-----------------
-------F----------------------------------VSNLDL-PND---ESP-G
----GSWGFPKNGLL-------MPLLGVIFLNGNR------ASEE---EIWEFLNIL---
-----GVY-DGR----KHFIFGEPRKLITEDLVQE------KYLEYRQV-PDSDPPCYEF
----LWGPKARAETS--KMKVLEFLAKVNDTVPS----A-FPPHYEE---ALRDEEERAQ
AR-AAARAGTG-AM----------------------------------------------
----------------------------------------------------------AS
--------------------ARS--R-----------------------ATSN-HSSR--
PY----------------------------------------------------------
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--------------------------------------MPRGQK---SKLRAREKR-RQA
-RT-----ETQGL-----------------------------------------------
-EV-------------AKASGAAA------------------------------------
-----------------------------------------------------------A
GKSP----------------------------SS-----V---------------FGDRP
ENLP-A------------------------AGTPS-------T-------PEAPEG---A
T--GATAA----------------------------------------------------
------------------------------------------------------------
-----------------SS----GTNSAENI---------------NS-P-KA-EST---
------------------------------S-F--PKGAESSLSEILNKKVVLLV-----
-------QFLLQKYQKKEPIR-KAEMM--KFVIKQYK-----SHYNEILKRASDH-----
----MELAFGVD---------LKE-VDPTR---------HCYT-----------------
-------L----------------------------------VNKLDL-SYD----SALN
----EYEHMPKTGIL-------MIVLGVIFMRGNC------APEE---AIWEVLNMM---
-----GVY-AER----KHFIYGDPKKVLTEDLVQL------KYLEYRQV-ANSEPPRYEF
----LWGPRAHAETS--KMKVLEFLAKVHDTVPT----A-FPSWYQE---ALRDEEERAR
AR-AAARARTA-AL----------------------------------------------
----------------------------------------------------------AS
--------------------ARS--R-----------------------ARAS-TSSQAK
------------------------------------------------------------
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---------------------------------------MDRRNDHGHRVPTFQ--G---
--------PLPPA--GSLGLP----------------------------FSPDVQSETTE
KDP-----------------------------PIASRSKK-------------NKNKKNS
IKPM----------DKT-TPA--PPPAPSANDNASNKPKVTLQALNLPMFTQISQASAT-
T------------------------------------------------EAPN-------
------IQASVTSQTQK--AKTMRVTP------KVSLTGSEDATTQLKPPLQALNLPVTT
PTIQT---PVANESANSLAS-TAVNKSKKAS---------------TAN-----------
-------------NAA----------------NKTVPSAAEISLASAATHTA-TTQGQAA
-KETGSIQTIAATARSKKNSKGKRTPA--KTTNTDNE-------YVEASNA---------
----IEAS--SRQIGASGRQTE------AS---------N-RQIEASSRQTEASNRQTEA
SS-------------------------R--QTE---------ASSRQTETSN----RQNG
AS--NRQIMASNRQI---------------GASNR--Q-IEASNR-QIGASNRQTEVSSR
-----QIE-A------SNRQIGASNRQTEASNRQIGASNRQTEASNRQIGAS----NRQT
DASNRQTEA---------------SSRQTEASSR---------QTE--A--SSRQTEASS
RQIEA--------------------S---------------------------------A
AAVRPKKPRGKKGNNKGS---------N------------SASEPSEAPPAIQTVTNHAL
SVTVRIRRGS----RARKA----ANKNRATESQA----QIAEQGAQAS----E-ASISAL
ETQ------------VA------------AAVQALADDYLAQL----SLEPTTRTRGKRN
RKS-----------------------------------------------KHPNGEERT-
GNNYRRIPWGRRLPP-PRDVAIL---QERANKLVK------YLLVKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LKDVIQEYEDYFPEIIERASYALEKMFRVNLKEIDKQNNLYI-LISTQES
SAG-IM-GTTKDT-PKLG---LLM----------VILSV----------IF--------M
-NGNK----A-S--EAVIWEVLRKLGLH--PGVKHSLFGEVKKLITDEFVKQK-------
---------YLEYKRVPNSRP---P--EYEFFWGLRSYHETSKMKVLKFACKVQKK---D
------PKDWAAQYREAVEMDIQAAAVAVA--EAKAR----AEARAQMGIGEEAV-----
------AGP--WNWDDMDINCLT-REELGDDAQAWS-RFSF----EIEPRAQENADPATN
VNFNQGATTRNSFSDGAGISFGGITNP--SGGFGGISNPSGG--------FGGIS----N
PSGGFGGISNPSGGFG--------------------------------------------
-------------------------------GISNPSGGFGGISNPSGGFGGISNPNGGF
GGISNPSGGFGGRNSITFGSVPNTSANFSSAPSISFGDTPNTSTSFSGGASSSFSGTPST
SAPFCNTASISFGGAPSTSTSFS-TASISFGGAPSTSTSLSTASISFGGAPSTSTSFSTA
SISFGGAPSTSTSFSSTASISFGGAPSINSS-SGGSSVSFGGAPT--TSTSFSGGPCISF
GGAPCTSASISGGASSGFGSTLCSTNPGFS-ALSTNTSFGSAPTTSTVFSGAVSTTTGFG
GTLSTSVCFGSSPYSGAGFGGTLSTSISFGGSPSTNTGFGG----TLSTSVSFGASSSTS
SDFGGTLSTSVSFGGSSGAN-AGFGGTLNSSTSFGGAISTSAGFGSALNNSASFGGAVST
SFSGVLNSSASFGGAINTSAGFGSTLNSSASFGSALSTSASFGGVLNGSAGFGGALNTNA
TFGGVLNGSAGFGGAMNTNATFGGALNSNAGFGGAISTSTNFGGALNNSAGFGGA-----
---------------MNTSASFGGALNNSAGFGGAISTNATFGGALNNSAAGFGGAISTN
ATFGGALNNSAGFGGAISTSASFGGTLNNSASFGGAINTSASFGGVLNNSAGFGGAINTS
ANFGGALTNSAGFGGAISTSASFGGALNNSAGFGGAISTSASFGGALNNSAGFGGAISTN
ASFGGAISNSPDFGGAFSTSVGFGGTLN-TTDFGSTHSNSISFGSAPTTSVSFGGSHSTN
LCFGGAPSTSLCFGSASNTNLCFGGSNST-NCFSGATSANFNEGHS----ISFGNGLSTS
AGFGNGLGTSAGFGSSLGTSTGFGGSLGPSASFNGGLGTSTGFGGGLGTSTDFSGGLNHN
ADFNGGLGNSAGFNGGLNTNTDFGGELGTSAGFGDGLGSSTSFGAGLVTSDGFAGNLGTN
TGFGGTLGTGAGFSVSLNNGNGFGNGPNASFNRGLNTIIGFGSGSNTSNGFTGEPNTGSS
FSNGPSSIVGFSGGPSTGAGFCSGPST-GGFGGGPSTGPGFGGPSTGP-GFGGPSTGGGF
GGPNTGGGFGGPSTGGGFGGPSTGGGFGGPSTGGGFGGPSTAAGFGSGLST---------
--STGFGGGLNTSAGFSGGPPSTGTGFGGGASSHGGCGFPYG

------------------------------------------------------------
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--------------------------------------------------------MAE-
----------------------------------------------------------RS
RS-----G-Q-------SGNSNSGDMDEGSQRAR--EEEMVGGNDYE----EFGAFGGYG
TLTSLDIHL--LRAFGSLG-----------------------------SGFRFLANEPWE
LENP-ALAQTLV-------EALQ--LDPDTLANETEARAA-------------NVARSAA
---S----------NRA-NRAA--------------------ASAARRSFNQA---ISNQ
M------------------------------------------------R-AA-------
------QQALVEDAQPMTYAE---AQ--------------------GATPETSHASQQTS
------QTLVASEGAAPGAPAP-STQPQTAF---------------LAQ-----------
-------------EAA----------------AEGPSTACAFTQAPSASERD-ATQPQTA
FLGQ----------------------------KDVFD-------FTQPAGV---------
----SGMAFPRPKRPAPAQEA--PTQGPSA---------AC-CVPQAAPAREGSATRPKT
T-----------------------------K-----------------------------
------------------------------------------------------------
--------------------------------------------------------SGKA
LAKTRWVEPQNVAAAA--------AAKA-KAATS---------IPEQEGAAA---TAQHS
AE-----------------------P---------------------------------W
TRMGGKRTKKSKHLVEDY--------ESSE-EEREPPAVPPTWRASQPPSL---------
---------A----Q---------------------------------------------
----------------------------------------AQSA----------------
-----------------PRPP-----------------------------V----A----
-PRSQIPSRHVLCLP-PRNVTLL---QERANKLVK------YLMIKD-YKKIPI--KR--
------------------------------------------------------------
----SDM---MKDVIREYDEHFPEIIERATYTLEKKFGIHLKEIDKEEHLYI-LICTRDS
SAR-LL-GKTKDT-PRLS---LLL----------VILGI----------IF--------M
-NGNR----A-S--EAILWEALRKMGLR--PGVRHPFLGDLRKLITDDFVKQK-------
---------YLEYKKIPNSSP---P--EYEFLWGLRARHETSKMRVLRFIAQNQNR---D
------PREWKAHFLEAVDDAFKTMDVEMA--EEHAR----AQMRAQMNIGDEAL-----
------IGR--WSWDDIQSELLT-WDEDGDFGDAWA-RIPF----AFWARYHQYILNSNR
ANRRA------TWRAGVSSGTNGGASTSILDGPSTS-ST---IRTRNAARVG--------
----ASFFSWIQQR----------------------------------------------
------------------------------------------------------------
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---------------------------------------MSDT-----------------
---------------SE-KGT----------------------------GPTRFQAEASE
-DSG-LKIQTLL-------TVTH--NLEVSEIPKTS------------------KA----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------LETSEAMKVS-------NAAGVS---------------KAT-----------
-------------EV---------------------------SKAPEAQEVA-ATQASPT
-TKLTDTQVLTV----EK--KSPAADT--KMQSADPQ-------PVTMPAT---------
----ETKK-----VSC--------------------------------------------
------------------------------------------------------------
--------------------------------------------------------VA--
-------------------------------DIKA-------------------------
----G-T--KALETEA--------PASQALADEP---------KP--DGAAAQAQENQDT
RPKVK--------------------A---------------------------------K
KARKVKHLNSEEDGN---------------SDQSQASGTTAGRRVSKALMASMARRASRG
PIAFWARRAS----RTRLA----A------------------------------------
------------------------------------WARRALL----SLRSPKARRGKAR
RRA---------------------------------------------------------
-AKLQS-SQEPETPI-PRDVALL---QGRANDLVK------YLLVKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LKDIIKEYTDVYPEIIERAGYSLEKVFGIQLKEIDKNDHLYI-LLSTLEP
TDAGIL-GTTKDS-PKLG---LLM----------VLLSI----------IF--------M
-NGNR----S-S--EAVIWEVLRKLGLR--PGIHHSLFGDVKKLITDEFVKQK-------
---------YLDYARVPNSNP---P--EYEFFWGLRSYYETSKMKVLKFACKVQKK---D
------PKEWAAQYREAMEADMKAAAEAAA--EAKVS----VELVLAPVAALVPVVS-PI
SEISDTPNP--SSLSL------------RARVHPQK-PTQIAL-----------------
------------------------------------------------------------
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------------------------------------------------------------
--------------------------------------MPRGQK---SKVCAREKH-HQA
-RS-----EIQVL-----------------------------------------------
-HD--------------QATTSRG------------------------------------
-----------------------------------------------------------E
-ETT-------------------------SSSLP-----D---------------SESAP
SSSS-A-------------------------AGT----------------PKGPQG---A
Q--GTTSAAAGAIPKRSGGGGT--------------------------------------
------------------------------------------------------------
--------ARSRS--------------GVGA---------------RG-Q-VQEGE----
-----------------------------NS-SQASAAAASSHRDLLTKKAQMLV-----
-------QHMLYKYKMRELIK-RSEML--KAIGRRYM-----KQFPEILSRASEH-----
----MEIVFGLV---------LKE-VRPNS---------HCYT-----------------
-------L----------------------------------VSNLDF-SDS----ESMR
----GDLGLPKNGLL-------MPLLSFIYLNGPR------ISEE---HIWKFLNIL---
-----GIY-DGR----RHFIFGDTRKLITEDLVQE------EYLEYRQV-PGSNPPRYEF
----LWGPKALTETN--KNKVMEFLAKVNDTVPD----A-CLAQYEE---SFRQEVESTG
ARAAA-RVGTSAS----------------GMAG---------------------------
-----------------------TSA----------------------------------
-S--------------------GMAGTFASGMAGM-----SA---------WVTACMSAS
VWD-----------------G---------------------PS-A-----AAQAEYLAS
---------ARPGISAAASAG-PSASASAHARAASSHS----------------------
------------------SRP---------------------------------------
------------------------------------------------------------
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------------------------------------------

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---------------------------------------MSDT-----------------
---------------SE-SGA----------------------------GSACFQTKASE
KDSG-SVMQTLL-------IVTQ--NLEVSETPKAS------------------KA----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------QEISEAAKIS-------KALGVS---------------KAM-----------
-------------KV---------------------------SKAPEAQEAP-TIQSSPT
-AQLTDTQVLTA----VN--KSPAADT--KTQNTDLQ-------AVTMPAT---------
----ETKK-----VSC--------------------------------------------
------------------------------------------------------------
--------------------------------------------------------VA--
-------------------------------DMKV-------------------------
----N-T--KASEIEA--------TASQPQVDE-----------PEHEGTTPQAQENQDT
RLKVK--------------------A---------------------------------K
KARKVKHLEGEEDGS---------------SDQSQTSGTTGGRRVSKALMASMAKRASRG
PIAFWARRAS----RTRLA----A------------------------------------
------------------------------------WARRALL----SLRSPKARRGKAR
RRA---------------------------------------------------------
-AKLQS-AQEPEALP-PRDVALL---QGRANDLVK------YLLAKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LKDIIKEYTDVYPEIIERAGYSLEKVFGIQLKEIDKNDHLYI-LLSTLEP
TDAGIL-GTTKDS-PKLG---LLM----------VLLSI----------IF--------M
-NGNR----S-S--EAVIWEVLRKLGLR--PGIHHSLFGDVKKLITDEFVKQK-------
---------YLDYARVPNSNP---P--EYEFFWGLRSYYETSKMKVLKFACKVQKK---D
------PKEWAAQYREAMEADLKAAAEAAA--EAKSR----AEIRAQMGIGHGSE-----
----NAAGP--CNWD-------------EADIGPWA-KARIQTGAEDKAKAQESG--GAS
TS--AST------G----TSTSAGASA--SGGFSASASLTATLTFGLFTGLGGSGASTSG
NSGACG-FSYK-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------

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------------------------------------------------------------
------------------------------------------------------------
------------------------------MDS------------------------KLL
F---TCFP-----------------------N----------SDLK--P-----------
------LGIQNLCLDTHPL---------------------------SL--PDPAG-----
-----------------------------------------------SHIR----HL---
-------------IHPHNQ-------------------------------------TPDT
PL-----PFRTFVLVLGHITPSSSSITPGSALARG-TEAMAQKMDCGAGLFGFQA-----
--------------------------------------------------------EASV
EDSA-LLMQTLM-------EAIQ--IS-EAPPTNQA--TA--------------------
------------------------------------------AASRPNASPQSSQPPTT-
N------------------------------------------------EMAD-------
------IQVVAAAARPKT------------------------------------------
-----------------------------AF---------------KAQ-----------
-------------NAT----------------PEGPNGACDFSQALNAKDMP-DTQPKAA
F-------------------KSQNDST--KGPNTAYD-------FSQAATT---------
----SELAVNKSEMAFKTQNTT-TNMGPNA---------T-YSFSQSLNAREKASIHPKT
------------------------------------------------------------
----------------------------------------------AFKALNDITMVPRG
-------------------------------DTQT-----------QDA-----------
----SQA---KMATSQ--------ADIETN--PG---------ISEPEGAAAQASADGSQ
AQNLE--------------------S---------------------------------R
TIIRGKRTRKINNLNM---------EENSSGDHRRAQLTTGTWRSATVPVTT-QNPPGAP
PNVLWQTPLA----WQNPS----GWQNQTTRQTP----M-ARQSPPVRQTPPAWQNPVAW
QNPVMWPNPVIWQNPVIWPNPI-VWSGPVVWPNPLAWQNPPGWQTPPSWQTPPGWQGPPD
WQG---LPDWPLPP--------DWLLP-TDWPLPPDWIPTDWPVPPDWQNLRPSPNLRP-
-SHNSRASQNPGVTQ-SRDVALL---QERANKLVK------YLMLKD-YTKVPI--KR--
------------------------------------------------------------
----SEM---LRDIIREYTDVYPEIIERACFVLEKKFGIQLKEIDKEEHLYI-LISTPE-
SLAGIL-GTTKDT-PKLG---LLL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPLLGDLRKLLTYEFVKQK-------
---------YLDYRRVPNSNP---P--EYEFLWGLRSYHETSKMKVLRFIAEVQKR---D
------PRDWTAQFMEAADEALDALDAAAA--EAEAR----AEARTRMGIGDEAV-----
------SGP--WSWDDIEFELLT-WDEEGDFGDPWS-RIPF----TFWARYHQNARSRFP
QTFAG---------------------P--IIGPSGAASA------NFAANFGAIGF----
--------FWVE------------------------------------------------
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--------------------------------------MEPTE-----------------
-----------------NNQ-SFNLL-D----------------IPEA----QIE-ERD-
-------------PGSAQDP----------------------------------------
------------------------------------------------------------
--------------------------------------IAEA------------------
------------------------------------------------------------
---GEVEAIATA----PGD--E--------------------------------------
----------P--------------------------------------AGGT---PSSP
QSAPRAPS---PPTAMG-S--IS-----------------------------GASFD---
------------N------PLSGMP------------DTEFPSQDGLNEKIIDLV-----
-------RFLLVKFRRMELTN-KEEMI--VKTMEGYE-----EHYSVIFSKAAEC-----
----MKLIFGVD---------MLE-VDPFV---------HSYF-----------------
-------L----------------------------------HPALGI-TYD----GM--
LH-GV-IGVPKTGLV-------IIVLCVIFIENNC------VREE---VFWHAMNIL---
-----GMQ-AGI----DHFIFGELRSLITEDFVEE------GYVEYRQV-ANSNPPCFEF
----LWGARAYAETT--KMKILEFYASIVRQDPR----S-YPEKYEE---ALREEQERA-
------------------------------------------------------------
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----------------------------------------MSQ-----------------
-----------------SSE-ECAAD-Q----------------G-QT----CEE-TQK-
-------------LQVAAAS----------------------------------------
-------------------------------------------------------I---D
VEEP----------------------------CSSPHLMAT------------------S
LKDQTS---------------------------------------EET------QVSKDV
EEPCSS-SQLLM----ASD---QD------------------------------------
---------DS--------------------------------------EDET---ASTS
SDLQHPYD---SSSEST-E--DLDDQEVQ----------------GSP-------VI---
------------P------PD--QS------------DSTDLPVMTVDGKVDFLV-----
-------NYMLYKYQVKEVMS-MNDIM--TLIVREDE-----DRFHEILMRASER-----
----MEMVFGLD---------VKE-VDPIN---------HCYA-----------------
-------L----------------------------------FIKLGL-TYD----GM--
RN-DE-YSFPKTGLL-------ILILGVVFMKGNR------ATEE---EIWEVLNPM---
-----GIY-AGM----THFMFGDPRELITDEFVRE------QYLEYQPI-ANSDPIQYEY
----VWGLRAKAETS--KMRVLEFVAKVHGSDPT----V-FLSQYEE---ALIEEEERTL
TMLLEHADSSS-------------------------------------------------
------------------------------------------------------------
-----------------------T-------SGE----------------SSS--D----
------------------------------------------------------------
---------TSS---------------------NF-------------------------
------------------SQV---------------------------------------
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--------------------------------------MDHMQ-----------------
-----------------NNQ-TCNLL-N----------------GSEV----QSE-AGD-
-------------LDSAQIP----------------------------------------
------------------------------------------------------------
--------------------------------------VAEE------------------
------------------------------------------------------------
-----AEATTTT----STE--M--------------------------------------
----------S--------------------------------------GGEA---PRSP
RSSPRSSC---PLAVTG-C--ISGK------------------------P-SDETSG---
------------N------QTEERK------------EAESPLNDEINTNVVRLV-----
-------EFLLLKYQRKELTT-KAEML--DCINRDYQ-----ECYPVIFSEASEC-----
----IKLFFGID---------MME-VDPAA---------RSYT-----------------
-------L----------------------------------VTALGI-TYD----GM--
HH-GP-QGMPNTGLI-------IMSLCIIFMEGNC------VSEE---KFWEVLNKL---
-----GLC-AGC----KHFIYDEPRKLITEDFVQE------GYLEYRLV-PDSDPPRHNF
----LWGPRAHAETT--KMKVLEFFAGITKKDPS----S-YPTRYAE---ALRDEGERA-
------------------------------------------------------------
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---------------------------------------MAQKMDCGEGLLGFQA-----
--------------------------------------------------------EASV
EDRT-LLMQTLM-------EAIQ--IS-EAPPTSQA--LA--------------------
------------------------------------------AAT----SPQCSQPPTA-
S------------------------------------------------ERVD-------
------IQVSAAAARPKT------------------------------------------
-----------------------------AF---------------KAQ-----------
-------------NAT----------------AKGSRGVYSFSKARNAKAIG-NTQPKTG
F-------------------KPRNATP--KCPNAAYD-------FSKAAAR---------
----SKLATSESEITLFKAQDVTTKVGPNP---------N-NSFSRSPNANEMVTDQPKT
------------------------------------------------------------
----------------------------------------------AFKAWNDTTKASVA
-------------------------------DTQT-------H--SQNV-----------
----NWA---KMATSQ--------ADTETN--PS---------IFEPDGAAAQTSADSSL
AQNLE--------------------S---------------------------------R
TIIHGKRTHKINNLNV---------EENICGDQMRAPLAAGTWRSAPVPVTT-QNPPGVP
PNVLWQTPLA----WQNPS----GWQNQTAGQTP----P-TRQNPPASQSPSSWQNLVAW
QNPVIWPSPIVWPGPVIWPHTFV-WPGPVVWPNPMAWQNPPGWHTQPGWQNTPGWQGPPD
WQG---PSDWPLPPDW-PLPP-DWPLP-TDWPLPPDRIPADWPILPDWQNLRPSPNLEP-
-SPNSRASQNMSASQ-PRDVALL---QERANKLVK------YLMLKD-YTKVPI--RR--
------------------------------------------------------------
----SEM---LRDIIREYTDVYPEIIERASFVLEKKFGIQLKEIDKEEHLYI-LISTPE-
SLAGIL-ATTKDI-PKLG---LLL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPLLGDLRKLLTYEFVKQK-------
---------YLEYRRVPNSHP---P--EYEFLWGLRSYHETSKMKVLRFIAEVQRK---D
------PRVWTAQFMEAAQEALDAMDAASA--EAEAR----AEARTRMGIGDEAV-----
------SGP--WSWDDIEFELLT-WDEEGDFDDPWS-RIPF----TFWPRYNQNGHSTIP
QTFAG---------------------P--IIGPGGTSTA------N----FSAIGF----
--------FWVE------------------------------------------------
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--------------------------------------------------MLQKPE---S
G--------------------------------------------------ALPIS----
-------QAE----------------------------REMDGSHDGETQALT-----A-
-SQEMAPSPLLQE----------RPEEDLGA---------------VREE-G--------
----------------ATEPSLTPKGA--RA-LAAKTLARRRACRRLDRTVAELV-----
-------QFLLLKDRKKSRIT-RSEMV--KYVIGDLK-----DLFPEIIARAAEH-----
----LRYVFGFE---------LKQ-LDRKH---------HTYI-----------------
-------L----------------------------------INKLKPIEDE--------
-EEALRGDGPRLGLL-------MMILGLIYMKGNS------AREA---QVWAMLRRL---
-----GVR-PSK----YHFLFGYPKRLIMEDFVQL------RYLNYRRV-PHTNPPECEF
----SWGPRSNLETS--KMKVLGFVAKLHKKEPQ----H-WPVQYRE---ALADEADRAR
AGAS-V----RA----------RS--------S---------------------------
------------------------------------------------------------
-TH----L------W---------------------------------------------
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--------------------------------------MSRY------------------
----------------GKHP-RLSLE-E-------------EGVNFQD----PPE-TD--
--------------ELPLVPTAEKEEREGEEEIKEE---DNN-----KLKNEED------
---NNEKQEDDES----KGE---------------------------KDGEEQGCDETGE
EENET----------GE-EENEQ-L--ATGLVPLPQAKRA-------------------D
---PHM---------------------------------------S-------S------
---S------------NCC--FSSAE----------------------------------
---------GY--------------------------------------SPGM---LSIF
QNAQSFFP---SS--------AIGGNLDE----------------GTSYQ-DES--V---
------------G------AIQSPE------------NPEALLNIVIQEKATDLV-----
-------FLFIYKYRMKEPIT-LSEIY--EVVTKDYE-----NHFPVIFMEASKC-----
----LEMTFGID---------IKE-SELLS---------SAYV-----------------
-------F----------------------------------VNSLNL-TYE----DMLS
---DN-DRLPRNAFL-------IVILGVIFIEGNC------ASEE---RIWEFLKLV---
-----GVH-DGE----EHFICGDPREFLTIDLVQQ------NYLEYRQV-PDSQPPCFEF
----LWGPRAYAETT--KMKVLEFLAKMNGCDPT----D-FSVWYEE---ALREEEERAW
AMNDSANGSPT-------------------------------------------------
------------------------------------------------------------
-----------------------SW------LVE----------------R---------
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--------------------------------------MPRGQK---SKIRAREKR-RQA
-RE-----EAQVG-----------------------------------------------
-PQ-------------APAAVAEE------------------------------------
------------------------------------------------------------
--AQ-------------------------ASCSP-----G---------------TKDIA
ESSP-P------------------------AWPPS-------P-------PQGLQR---G
S--STSTPAA-A------------------------------------------------
------------------------------------------------------------
-----------------VP----CTDSEEGA---------------NT-Q-EE-ESA---
-----------------------------KS-AQAQPVTARWLRGPVDIKVAMLV-----
-------HYLLHKYQMKEPIT-KGDML--KNVIQTYK-----SHYLEILKKASHH-----
----LELIFGLD---------VKE-VDTSK---------HTYV-----------------
-------L----------------------------------VNKLEM-SCE----GKTN
----EDRGLPKTGLL-------MAVLGVILTKGNC------ATEE---EVWEVLNLM---
-----GVY-AER----RHFIFGDPKQLLTKDMVQL------NYLEYRQV-PNSNPPCYEF
----LWGPRAHAETT--KMKVLEFLAKIHNTIPS----A-FPLLYEE---AMRDEEERAQ
AR-AAARAHMS-TT----------------------------------------------
----------------------------------------------------------AS
--------------------ARA--R-----------------------AIPS-S-SCPK
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--------------------------------------MADFH-----------------
-----------------NTQ-YCNLE-E----------------SAQA----QQE-----
-------------SDNDQET----------------------------------------
------------------------------------------------------------
--------------------------------------METS------------------
------------------------------------------------------------
---EEEE-DTTT----SNK--V--------------------------------------
----------Y--------------------------------------GSAI---PSPP
QSPQRAYS---PCVALA-S--IPDS------------------------P-SEEASI---
------------K------GSGGLE------------DPLYLLHSAQNTKVYDLV-----
-------DFLVLNYEMKAFPT-KAEML--ESIGREYE-----EYFPVIFSEASEC-----
----LKMVFGLD---------MVE-VDPSV---------HSYM-----------------
-------L----------------------------------VTALGI-TYD----GM--
MT-DV-QGMPKTGIL-------IAVLSVIFMKGNY------VSEE---VIWEMLNNI---
-----GLC-GGR----DPYIHKDPRKLISEEFVQE------GYLEYRQV-PNSDPPIYGF
----LWGPRALAETS--KMKVLQFFASINKTHPR----A-YPEKYAE---ALRDEIERTK
AWILSRCSNFS-------------------------------------------------
------------------------------------------------------------
-----------------------DH-------------------------SS---V----
------------------------------------------------------------
---------LPF------------------------------------------------
------------------PF----------------------------------------
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---------------------------------------MAQKPDGGAGLRGFQA-----
--------------------------------------------------------EASV
EDSA-LLVQTLM-------EAIQ--IS-EAPPTSQA--TA--------------------
------------------------------------------AASGPNASPQSSQPPTA-
N------------------------------------------------EKAD-------
------TEVSAAAARPKT------------------------------------------
-----------------------------GF---------------KAQ-----------
-------------NTT----------------TKGPN---DYSQARNAKEMP-KNQPKVA
F-------------------KSQNATS--KGPHAASD-------FSHAAST---------
----GKSAAKKSEMAFKGQNTT-TKAGPSA---------T-YNFTQSPSANEMTNNQPKT
------------------------------------------------------------
----------------------------------------------A-KAWNDTTKIPGA
-------------------------------DAQT-----------QNV-----------
----NQA---KMADVG--------T------SAG---------ISETDGAAAQTSADGSQ
AQNVE--------------------S---------------------------------R
TIIRGKRTRKINNLNV---------EENSNGDQRRASLASGNWRSAPVPVTT-QNPPGAP
PNVLWQTPLA----WQNPS----GWQNQTARQTP----P-ARQSPPARQTPSAWQNPVAW
QNPVIWPNPVIWQNPVIWPNPI-VWPGPIVWPNPMAWQSTPGWQSPPSWQAPPSWQSPQD
WQG---PPDWQLPPDW-SMPP-DWSFP-SDWPFPPDWIPADWPIPPDWQNLRPSPNLRS-
-SPNSRASQNQGPPQ-PRDVALL---QERANKLVK------YLMLKD-YTKVPI--KR--
------------------------------------------------------------
----SEM---LRDIIREYTDVYPEIIERACFVLEKKFGIQLKEIDKEEHLYI-LISTPE-
SLAGIL-GTTKDT-PKLG---LLL----------VILGI----------IF--------M
-NGNR----A-T--EAVLWEALRKMGLR--PGVRHPLLGDLRKLLTYEFVKQK-------
---------YLDYRRVPNSNP---P--EYEFLWGLRSYHETSKMKVLRFIAEVQKR---D
------PRDWTAQFMEAADEALDALDAAAA--EAEAR----AEARNRMGIGDEAV-----
------SGP--WSWDDIEFELLT-WDEEGDFGDPWS-RIPF----TFWARYHQNARSRFP
QAFTG---------------------P--IIGPSGTATA------NFAANFGAIGF----
--------FWVE------------------------------------------------
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--------------------------------------MSQD-Q----------------
-----------------ESP-RCTHD-Q----------------HLQT----FSE-TQS-
-------------LEVAQVFKALE------------------------------------
-----------------------------------------------------------K
T-----------------------------------------------------------
------------------------------------------------------------
---FLSSSHPLV----PGK--LKEA---P---------------------AAK-------
----------A--------------------------------------ESPL-------
EVPQSFCS---SSIAIT-T--TSSSESDE----------------ASSSQ-EEEDSP---
------------S------SSEDTS------------DPRNVPADALDQTVAFLV-----
-------NFMLHKYQMKKPIT-KADML--KIIIKDDE-----SHFSEILLRASER-----
----LEMIFGLD---------VME-VEPTT---------HCYG-----------------
-------L----------------------------------FIRLGL-TYD----GMLS
---GE-KGMPKTGLL-------ILVLGVIFMKGNR------ATEE---EVWEVLNLT---
-----GIY-SGK----KHFIFGEPRELITKDFVKE------KYLEYQQV-ANSDPARYEF
----LWDPRAKAETS--KMKVLEFVAKVHGSYPH----S-FPSQYAE---ALKEEGERAR
ARI---------------------------------------------------------
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---------------------M-------SLVSQNARQ----------------------
------------------------------------------------------------
------------------SSAETT------------------------------------
-----------------------------------------------------------A
-DY---------------------------------------------------------
-----------------------------------------------------------S
N--SQGEMQA----------------TNASGP------------A-T-------------
---------------------------------------------------SM------L
----------ALEAPQ----GPEIPNDPQGA---------------SASQ-AV-------
---------RDP----S--DIEV--LID-EQSRRLGA---LRVHDPLEERSVALV-----
-------NFMRMKSQNEGSIR--QSEM--LEFLKEYS-----DQFPEILRRASAH-----
----LDRVFGLN---------LRV-LDPQM---------DTYN-----------------
----------------------L-------------------ISKPGP-QTT----ERLA
----ETLDIPKAGLL-------ALVLGHILLNGNR------AREA---SIWDLLLKV---
-----DVI---DGSQRINNQFGNTRNLLTIDFVHM------RFLEYWPV-YGTNPLEFEF
----LWGSRAHS--EITKM-----------------------------------------
------------------------------------------------------------
--------------------------E-------------------------------AL
K-----------------------F---VA----------------EAHDEEP-------
------------------------WSWPE-EYN------------KALEADKAKER---S
---------------------------------------------------------QA-
AG---L--------E-FWSED---TMNDKANELVQ------LAIGVT-EELLPI--HQ--
------------------------------------------------------------
----DEL---FANTGKEFQDVFPNILSRATLILDLFYGFSLIEVDTSEHIYL-LVPQPES
EEEQVM-LESLGR-PTQE---YLM----------PILGL----------IF--------L
-MGNR----V-K--EAKIWNLLQRFSVD--VGRKHAI--------TCKLMRQR-------
---------YLECRPLSYSNP---V--EYELLWGPRAHHEITKMKALEYMARFYGK---Q
------PQDWPEQYREAVE-----------DEEARARSEATAMFF----FGS--------
---I--------------------------------------------------------
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-----------------------------------------------------------E
E-DT-----------------------SSSSTCSSSFPFSS-------------------
------------------------------------------------------------
S-SSSYSL---I----SSS--PGE--ELN---------------------VIPGPP---G
-PSQDPSQGPS--------------------------------------QDPS---QGPS
QSPPSSSL---SPTA-V-A--SPMSESGD----------------S-PSS-QKEESP---
------------S------TSQALP------------NAESLPRNVIDDRVADMV-----
-------EFLLLKYRTKELTT-KAEML--NVVIKDYQ-----DHFPEIFREASEC-----
----LQLAFGVD---------VKE-VDPSD---------DSYA-----------------
-------L----------------------------------VTTLGL-TCD----GLMS
---DG-ETMPKNGIL-------IVILSMIFMEGGC------VSEE---KVWEVLNVM---
-----GVY-DGT----EHFIYGEPRELITRVLVQE------QYFEYRQV-PNSDPARYEF
----LWGPRAHSEIY--KMTLLEFLAKISGSDPR----A-FPLWYEE---ALRQQEERAQ
SGLATMDDTSA-------------------------------------------------
------------------------------------------------------------
-----------------------VA--------S----------------ESS----SA-
------------------------------------------------------------
----------PS---------------------SSFC-----------------------
------------------P-----------------------------------------
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--------------------------------------MPRGQK---SKLRSCEKR-RQA
-RG-----GTRTV-----------------------------------------------
-TS-------------AQATVAEE------------------------------------
-----------------------------------------------------------E
-GSP-------------------------SSSSP-----P---------------SRDSP
NSSP-A------------------------AAGI----------------PQEPPK---V
P--PITTAA-AG------------------------------------------------
------------------------------------------------------------
-----------------AS----GTGAAGGA---------------EG-Q-DE-GGP---
-----------------------------GS-SEAPAPTERSQRDPLTRRVSMLL-----
-------QFLLHKYKMKEPIT-KAEML--KIINKRYK-----EHFSDILRRASEH-----
----MELVFGLD---------LKE-VDSTG---------QSYT-----------------
-------I----------------------------------VSKLEI-TKE---ENL-S
----GGRGFPKTRLL-------MPLLGIIYMNGNR------ATEE---EIWEFLSFL---
-----GIY-DGK----RHFIFGDPRKLITKDLVQE------EYLEYRKV-PNSDPPRYEF
----LWGPRAHAEAS--KMKVVEFLAKINDTDPH----A-FQNLYEE---TWVDEAKRAA
AG-EWAGAGPN-AR----------------------------------------------
----------------------------------------------------------AR
--------------------AHF--Q-----------------------AKST-RSSHP-
------------------------------------------------------------
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---------------------------------------S---------------PKL-A
PSPV--------------------------HASIA-------L-------FSCPRS---P
Q--PKRETPGS----------LSPQVKPSQGP------------S---------------
----PSGLRA--------------------------------------------------
------APP--------------AP------------------------------SR---
----------------------RHQAT------DPSI-SLHMSPAQLVQKAHELM-----
-------WYVLVKDQKKMIIW-FPDMV--KDVIGSYK-----KWCRSILRRTSLI-----
----LARVFGLH---------LRL-TSLHT---------MEFA-----------------
-------L----------------------------------VKALEPEELD-----RVA
----LSNRMPMTGLL-------LMILSLIYVKGRG------ARES---AVWNVLRIL---
-----GLR-PWK----KHSTFGDVRKLITEEFVQQ------NYLKYQRV-PYVEPPEYEF
----FWGSRASREIT--KLQIMEFLARVFKKDPQ----A-WPSRYRE---ALEEARALRE
ANPAA----------------------------------HCPRSSVSED-----------
------------------------------------------------------------
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------------------------------------------------------------
--------------------------------------MPRGQK---SKLRAREKR-RKA
-RD-----ETQGL-----------------------------------------------
-NV-------------PQVTEAEE------------------------------------
-----------------------------------------------------------E
-EAP-------------------------CCSSS-----V---------------SGGAA
SSSP-A-------------------------AGI----------------PQKPQR---A
P---TTAAAAAA------------------------------------------------
------------------------------------------------------------
----------------RVS----STKSKKGA---------------KSHQ-GE-KNA---
-----------------------------SS-SQASTSTESPSEDPLTRKSGLLL-----
-------QFLLYKYKIKESVT-KREML--KIVGKRFR-----EHFPEILKKASEG-----
----LSVVFGLE---------LNK-VNPNG---------HTYT-----------------
-------F----------------------------------NDMVDL-TDE---ELL-L
----SSWDFPGRKLL-------MPLLGVIFLNGNS------ATEE---EIWEFLNML---
-----GVY-DGE----EHSVFGEPRKLITKDLVQE------KYLEYKQV-PSSDPPRFQF
----LWGPRAYAETS--KMKVLEFLAKVNGTTPC----A-FPTHYEE---ALKDEKKAGV
------------------------------------------------------------
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-----------------------------------------------------MSEQSKD
LSD---------------------------------------------------------
------------------------------------------------------------
--------PNF----------------------------A---------------AEA-P
SSEV--------------------------HSS-----------------PGVPEG---V
P--PS-----ET---------LAEPQSPPLGP------------T---------------
----AAPQAA--------------------------------------------------
------QPP--------------QAPSDEDD---------PKAL-QQA-A-EE--GR---
----------------------AHQAP----SAAQPG-PAPPAPAQLVQKAHELM-----
-------WYVLVKDQKKMIIW-FPDMV--KDVIGSYK-----KWCRSILRRTSLI-----
----LARVFGLH---------LRL-TSLHT---------MEFA-----------------
-------L----------------------------------VKALEPEELD-----RVA
----LSNRMPMTGLL-------LMILSLIYVKGRG------ARES---AVWNVLRIL---
-----GLR-PWK----KHSTFGDVRKLITEEFVQQ------NYLKYQRV-PYVEPPEYEF
----FWGARASREIT--KLQIMEFLARVFKKDPQ----A-WPSRYRE---ALEEARALRE
ANPAA----------------------------------HCPRSSVSED-----------
------------------------------------------------------------
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-----------------------M----------VLLSI----------IF--------M
-NGNR----S-S--EAVIWEVLRKLGLR--PGIHHSLFGDVKKLITDEFVKQK-------
---------YLDYARVPNSNP---P--EYEFFWGLRSYYETSKMKVLKFACKVQKK---D
------PKEWAAQYREAMEADLKAAAEAAA--EAKAR----AEIRAQMGIGLGSE-----
----NAAGP--CNWD-------------EADIGPWA-KARIQAGAETKAKA--QESGGAS
ASASAGASTGASVGTGA--SAGASAGA--SGGFSTSSNLTATLTFGLFAGLSGAGASTSG
SSGACG-FSYK-------------------------------------------------
------------------------------------------------------------
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---------------------------------------MSDT-----------------
---------------SE-SGA----------------------------GLTSFQAEASE
KDSS-SMMQTLL-------TVTQ--NVEVPETPKAS------------------KA----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------PEVSEDVKVS-------KASGVS---------------KAT-----------
-------------EV---------------------------SKTPEAQEAP-ATEASST
-TQLTDTQVLAA----EN--QSLAADT--KKQNADPQ-------AVTMPAT---------
----ETKK-----VSC--------------------------------------------
------------------------------------------------------------
--------------------------------------------------------VA--
-------------------------------DTKV-------------------------
----N-T--KAQETEA--------AASQAPADEP---------EP--ESAAAQSQENQDT
RPKVK--------------------A---------------------------------K
KARKVKHLDGEEDGS---------------SDQSQASGTTGGRRVSKALMASMARRASRG
PIAFWARRAS----RTRLA----A------------------------------------
------------------------------------WARRALL----SLRSPKARRGKAR
RRA---------------------------------------------------------
-AKLQS-SQEPEAPP-PRDVALL---QGRANDLVK------YLLAKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LKDIIKEYTDVYPEIIERAGYSLEKVFGIQLKEIDKNDHLYI-LLSTLEP
TDAGIL-GTTKDS-PKLG---LLM----------VLLSI----------IF--------M
-NGNR----S-S--EAVIWEVLRKLGLR--PGIHHSLFGDVKKLITDEFVKQK-------
---------YLDYARVPNSNP---P--EYEFFWGLRSYYETSKMKVLKFACKVQKK---D
------PKEWAAQYREAMEADLKAAAEAAA--EAKAR----AEIRARMGIGLGSE-----
----NAAGP--CNWD-------------EADIGPWA-KARIQAGAEAKAKAQESG--SAS
TGASTSA------NNSA------SAST--SGGFSAGASLTATLTFGLFAGLGGAGASTSG
SSGACG-FSYK-------------------------------------------------
------------------------------------------------------------
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--------------------------------------------------MLQKPE---S
G--------------------------------------------------ALPIP----
-------QAE----------------------------G-KDGGRDGETQALT-----A-
-SQEE------------------SSKEDLGA---------------GREE-G--------
----------------AAEPALTPKGA--RT-LAAKALARRRAYRRLDRTVAELV-----
-------QFLLVKDKKKSPIT-RSEMV--KYVIGDLK-----DLFPEIIARAAEH-----
----LRYAFGFE---------LKQ-LGRKH---------HTYI-----------------
-------L----------------------------------INKLKPLEEE--------
-EEDLGGDGPRLGLL-------IMILGLIYMKGNS------ARET---QVWEMLRRL---
-----GMR-PSK----YHFLFGYPKRLILEDFVQQ------RYLNYRQV-PHTNPPECEF
----SWGPRSNLEIS--KMKVLGFVAKLHKKEPH----H-WPVQYRE---ALADEADRAR
AKAR-AEASMRA------------RARANQRAG---------------------------
------------------------------------------------------------
-IH----P------W---------------------------------------------
------------------------------------------------------------
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--------------------------------------MPRGQK---SKHRAREKR-RQA
-RG-----DTHSP-----------------------------------------------
-EG-------------VQATSAEG------------------------------------
-----------------------------------------------------------E
-GSP-------------------------SSSSP-----P---------------FEGFP
QGSY-A-------------------------ASI----------------LQGPQR----
------------------------------------------------------------
------------------------------------------------------------
----AHITS---SVAAGAS----GIGAVGGA---------------EG-Q-DA----G--
----------GA-----------------RS-SEAPPSTERSPRDPLTCRVSMLL-----
-------QFLLQKYHMNEPFT-KGGMM--KIVHRRFK-----EHFPEILKRASEH-----
----IELVFGLD---------LKE-VDAKS---------QSYI-----------------
-------I----------------------------------VNKLEL-TDE----ENLR
----GGRGVPRNALL-------LPILGLVCANGKQ------ATEM---EMWEFLNLL---
-----GVY-DGR----KHFIFGEPRKLITEDLVHA------QYLEYRQI-----------
------------------------------------------------------------
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---------------------------------------MAQKMDCGAGLLGFQA-----
--------------------------------------------------------EASV
EDSA-LLMQTLM-------EAIQ--IS-EAPPTNQA--TA--------------------
------------------------------------------A-----ASPQSSQPPTA-
N------------------------------------------------EMAD-------
------IEVSAAAARPKS------------------------------------------
-----------------------------AF---------------KVQ-----------
-------------NAT----------------TKGPNGVYDFSQAHNAKDVP-NTQPKAA
F-------------------KSQNATP--KGPNAAYD-------FSQAATT---------
----GELAANKSEMAFKAQNAT-TKVGPNA---------T-YNFSQSLNANDLANSRPKT
------------------------------------------------------------
----------------------------------------------PFKAWNDTTKAPTA
-------------------------------DTQT-----------QNV-----------
----NQA---KMATSQ--------ADIETD--PG---------ISEPDGATAQTSADGSQ
AQNLE--------------------S---------------------------------R
TIIRGKRTRKINNLNV---------EENSSGDQRRAPLAAGTWRSAPVPVTT-QNPPGAP
PNVLWQTPLA----WQNPS----GWQNQTARQTP----P-ARQSPPARQTPPAWQNPVAW
QNPVIWPNPVIWQNPVIWPNPI-VWPGPVVWPNPLAWQNPPGWQTPPGWQTPPGWQGPPD
WQG---PPDWPLPPDW-PLPP-DWPLP-TDWPLPPDWIPADWPIPPDWQNLRPSPNLRP-
-SPNSRASQNLGAAQ-PRDVALL---QERANKLVK------YLMLKD-YTKVPI--KR--
------------------------------------------------------------
----SEM---LRDIIREYTDVYPEIIERACFVLEKKFGIQLKEIDKEEHLYI-LISTPE-
SLAGIL-GTTKDT-PKLG---LLL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPLLGDLRKLLTYEFVKQK-------
---------YLDYRRVPNSNP---P--EYEFLWGLRSYHETSKMKVLRFIAEVQKR---D
------PRDWTAQFMEAADEALDALDAAAA--EAEAR----AEARTRMGIGDEAV-----
------SGP--WSWDDIEFELLT-WDEEGDFGDPWS-RIPF----TFWARYHQNARSRFP
QTFAG---------------------P--IIGPGGTASA------NFAANFGAIGF----
--------FWVE------------------------------------------------
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--------------------------------------MPRGQK---SKLRAREKR-QRT
-RA-----QTQDL-----------------------------------------------
-KV-------------GQATAAEK------------------------------------
-----------------------------------------------------------E
-ESP-------------------------SSSSS-----V---------------LGDTP
SSSL-A-------------------------LGI----------------PQKPQR---E
P--RTTPAAAAMSGTG--------------------------------------------
------------------------------------------------------------
--------------------------PDEGE---------------ES-Q-DEENA----
-----------------------------SS-SQASTSTERSLKDPLTRKTKMLV-----
-------QFLLYKYKMKEPTT-KAEML--KIISKKYK-----EHFPEIFRKVSQR-----
----TELVFGLA---------LKE-VNPTT---------HSYI-----------------
-------L----------------------------------VSMLGP-TND----GNQS
----SAWSLPRNGLL-------MPLLSVIFLNGNC------AGEE---EIWEFLNML---
-----GIY-DGK----RHLIFGEPRKLITQDLSLC------RNQQD-ES-PGV------F
----GQGE----------------------------------------------------
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--------------------------------------------------MLQKPR---N
R--------------------------------------------------GRSSG----
-------QAE----------------------------RDSDWSRGGNSGASR-----AG
EDARARRDGFAEE----------APSTSRGP---------------GGSQ-G--------
------------------SQGPSSQGA--RR-SQASPAVGSRTPKQQELKVSELV-----
-------QFLLIKDQKKIPIK-RADIL--KHVIGDYR-----DIFPDLLKWAAER-----
----LQYVFGYK---------LVE-LEPKS---------NTYI-----------------
-------L----------------------------------INTLEPVEED----AEVR
----GDQGTPTTGLL-------MIVLGLIFMKGNT------IKET---EVWDFLRRL---
-----GVY-PTK----KHFIFGDPKKLITEDFVRQ------RYLEYRRI-PHTDPVDYEF
----QWGPRTNLETS--KMKVLKFVAKVHNQDPK----D-WPAQYCE---ALADEENRAR
PQPS-GSAPS--S-----------------------------------------------
------------------------------------------------------------
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--------------------------------------------------------MAE-
----------------------------------------------------------GS
FS-----V-Q-------SENYSVEDMDEGSDEVG--EEEMVEGNDYE----EFGAFGGYG
TLTSFDIHI--LRAFGSLG-----------------------------PGLRILSNEPWE
LENP-VLAQTLV-------EALQ--LDPETLANETAARAA-------------NIARAAA
---S----------NRA-ARAA--------------------AAAARTAFSQV---VASH
R-------------------------------------------------VAT-------
------PQVSGEDTQPTTYAA--EAR--------------------GPTPEPPLASPQTS
------QMLVTSEMAAPGAPAT-SAQSQTGS---------------QAE-----------
-------------EAA----------------TEGPSSACAFSQAPCAREVD-ANRPSTA
FLGQ----------------------------NDVFD-------FTQPAGV---------
----SGMAFPRPKRPAPAQEA--ATEGPSA---------AS-GVPQTGPGREVAATRPKT
T-----------------------------K-----------------------------
------------------------------------------------------------
--------------------------------------------------------SGKA
LAKTRWVEPQNVVAAA--------AAKA-KMATS---------IPEPEGAAA--ATAQHS
AE-----------------------P---------------------------------W
ARMGGKRTKKSKHLDDEY--------ESSE-EEREPPAVPPTWRASQPSLT---------
---------V----R---------------------------------------------
----------------------------------------AQLA----------------
-----------------PRPP-----------------------------M----A----
-PRSQIPSRHVLCLP-PRNVTLL---QERANKLVK------YLMIKD-YKKIPI--KR--
------------------------------------------------------------
----ADM---LKDVIREYDEHFPEIIERATYTLEKKFGIHLKEIDKEEHLYI-LVCTRDS
SAR-LL-GKTKDT-PRLS---LLL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPFLGDLRKLITDDFVKQ--------
--------KYLEYKKIPNSNP---P--EYEFLWGLRARHETSKMRVLRFIAQNQNR---D
------PREWKAHFLEAVDDAFKTMDVDMA--EEHAR----AQMRAQMNIGDEAL-----
------IGR--WSWDDIQVELLT-WDEDGDFGDAWA-RIPF----AFWARYHQYILNSNR
ANRRA------TWRAGVSSGTNGGASTSVLDGPSTS-ST---IRTRNAARAG--------
----ASFFSWIQHR----------------------------------------------
------------------------------------------------------------
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--------------------------------------MPRGKK---SKRRARERR-RQA
-QL-----EAGRV-----------------------------------------------
-LS-------------AQTSTEEG------------------------------------
-----------------------------------------------------------D
-ESS-------------------------SSSSS-----S----------------EVSS
LGTP-E-------------------------PAL----------------SQEPQG---A
T--AA-------------------------------------------------------
------------------------------------------------------------
-----------------IT----SPRK---------------------------------
------------------------------------------RRSPLDQKAMLLA-----
-------QFMLRKYNMKQPIT-REDMM--KHVVRKHK-----SYFQEILKRATEL-----
----MVLAFGID---------VKE-ADPAG---------QSYV-----------------
-------L----------------------------------VSKLHH-RGD----SSLH
-----GKIMPKKGLL-------MTILCVIFMKGNC------ATEE---EIWDVLNAM---
-----GIH-AGK----EHNLHGEPTKLLTEDLVKE------GYLEYRLV-PHSDPPSHEF
----LWGPQAYAETS--KMEVLEFLAKLHDTQPS----A-FPHWYEE---ALQDELERTR
QRFA-AVI----------------------------------------------------
-----------------------------------------------------------R
--------------------AASPA------------------------------CD---
------------------------------------------------------------
------------L-----------------------------------------------
------------------SSTHF-----SNP-----------HMY---------------
------------------------------------------------------------
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---------------------M-------SLVSQNARR----------------------
------------------------------------------------------------
------------------CSAEIT------------------------------------
-----------------------------------------------------------A
-DY---------------------------------------------------------
-----------------------------------------------------------S
D--GRGEIQA----------------TNASGS------------P-T-------------
---------------------------------------------------SM------L
----------VVDAPQ----CPQAPINCQCV---------------NTSQ-AV-------
---------QDP----N--DLEV--LID-EQSRRLGA---LRVHDPLEDRSIALV-----
-------NFMRMKSQKEGSIQ--QSEM--LEFLREYS-----DQFPEILRRASAH-----
----LDQVFGLN---------LRV-IDPQA---------DTYN-----------------
----------------------L-------------------VSKRGS-QIT----DRIA
----ESLDMPKASLL-------ALVLGHILLNGNR------AREA---SIWDLLLKV---
-----DMW---DKPQRINNLFGNTRNLLTTDFVRM------RFLEYWPV-YGTNPLEFEF
----LWGSRAHR--EITKM-----------------------------------------
------------------------------------------------------------
--------------------------E-------------------------------AL
K-----------------------F---VS----------------DAHDEEP-------
------------------------WSWPE-EYN------------KALEADKTKER---S
---------------------------------------------------------LT-
AG---L--------E-FWSED---TMNDKANDLVQ------LAISVT-EEMLPI--HQ--
------------------------------------------------------------
----DEL---LAHTGKEFEVVFPNILNRATLILDMFYGLSLIEVDTSEHIYL-LVQQPES
EEEQVM-LESLGR-PTQE---YVM----------PILGL----------IF--------L
-MGNR----V-K--EANVWNLLQRFSVD--VGRKHAI--------TRKLMRQR-------
---------YLECRPLSYSNP---V--EYELLWGPRAHHETTKMKVLEYMARLYRK---R
------PQDWPEQYREAVE-----------DEEARAKSEATTMFF----LGP--------
---T--------------------------------------------------------
------------------------------------------------------------
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--------------------------------------MPLEQ-----------------
-----------------RSQ-HCKPE-E----------------GLEA----RGE-ALG-
-------------LVGAQAPATEE------------------------------------
-----------------------------------------------------------Q
H-T---------------------------------------------------------
------------------------------------------------------------
----ASSSSTLV----EVT--LGE------------------------------------
---------VP--------------------------------------AAES---PGPT
QSPQGASS---FSTTIN-Y--TLWSQSDE----------------GSSN--QEEEGP---
------------R------MFPDL---------------ESEFQAALSRKVTELV-----
-------HFLLLKYRAREPFT-MTEML--ESVMRNCQ-----YFFPVIFSKASEY-----
----LQLVFGIE---------VME-VVPVG---------HLYI-----------------
-------L----------------------------------VTCLGL-SYD----GLLG
---DN-QIMPKTGLL-------IIVLAIIAIEGDS------VPEE---KIWEELSVL---
-----EVF-DGR----EDSVFAHPRKLLTQDLVQE------NYLQYRQV-PGSDPACYEF
----LWGPRALVETS--YVEVLYHMLKISGEPHI----S-YPPLHEW---ALREAEE---
------------------------------------------------------------
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---------------------------------------------------MVTQVSR-R
VGSSPSRIKERKTREDSG--GLAFQISGDLGPGLLRST---QRPPSGRQT----------
---------QWSQDLPRVLVRNV----------RANPE---DRIPW-RSQR---------
----------STKEKICLWVPIAQLLPVLPPAALTRVVMSLEQ-----------------
-----------------KSQ-HCKPE-E----------------GVEA----QEE-ALG-
-------------LVGAQAPATEE------------------------------------
-----------------------------------------------------------Q
E-A---------------------------------------------------------
------------------------------------------------------------
---AASSSSPLV----PGT--LEE------------------------------------
---------VP--------------------------------------AAGS---TGPP
QSPQGASA---LPTTVN-F--TCWRQPNE----------------GSSS--QEEEGL---
------------S------TSPDP---------------ESLFREALSKKVDELV-----
-------HFLLLKYRAKELVT-KAEML--ERVIKNYK-----HCFPVIFGKAAES-----
----LKMIFGID---------VKE-VDPTS---------NTYT-----------------
-------L----------------------------------VTCLGL-SYD----GLLG
---GN--IFPKTGLL-------IIVLGTIAMEGDS------ASEE---EIWEELSVM---
-----DVY-DGR----EHIVYGEPRKLLTQEWVQE------NYLEYRKV-PGSDPARYEF
----LWGPRALAETS--YVKVLEHVVRVNARVRI----S-YPSLREA---ALREEEEGV-
------------------------------------------------------------
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------------------------------------------------------------
--------------------------------------MSSEQ-----------------
-----------------KSL-HCKPE-E----------------GLEA----QEE-ALG-
-------------LVGAQAPTTEE------------------------------------
-----------------------------------------------------------Q
E-A---------------------------------------------------------
------------------------------------------------------------
---AVSSSSPLV----PGT--LEE------------------------------------
---------VP--------------------------------------AAES---AGLP
QSPQGASA---LPTTIS-F--TRWRQPNE----------------GSSS--QEEEGP---
------------S------TSPDA---------------ESLFREALSNKVDELA-----
-------HFLLRKYRAKELVT-KAEML--ERVIKNYK-----RCFPVIFGKASES-----
----LKMIFGID---------VKE-VDPTS---------NTYT-----------------
-------L----------------------------------VTCLGL-SYD----GLVG
---NN-QIFPKTGLL-------IIVLGTIAMEGDS------ASEE---EIWEELGVM---
-----GVY-DGR----EHSVYGEPRKLLTQDWVQE------NYLEYRQV-PGSDPPRYEF
----LWGPRALAETS--YVKVLEHVVRVNARVRI----A-YPSLREA---ALLEEEEGV-
------------------------------------------------------------
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--------------------------------------------------MLQKPR---N
R--------------------------------------------------GRSSG----
-------HAE----------------------------RVRDASQN--------------
--SRAPRDCVAEE----------APSTSRGP---------------GGTQ-G--------
------------------ARGSSPQGA--RR-SLAAPTVGPRTQKQLELKVSELV-----
-------QFLLIKDQKKIPIK-RADIL--KHVVGDYK-----DIFPDLLKLAAER-----
----LQYVFGYK---------LVE-LEPKS---------NTYI-----------------
-------L----------------------------------INTLEPVEED----AEVR
----GDQGTPTTGLL-------MIVLGLIFMKGNT------IKET---EVWDFLRRL---
-----GVY-PTK----KHLVFGDPKKLITEDFVRQ------RYLEYRRI-PHTDPVDYEF
----QWGPRTNLETS--KMKVLKFVAKVHNQDPK----D-WPAQYCE---ALADEENRAR
SQPS-GPAPS--S-----------------------------------------------
------------------------------------------------------------
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--------------------------------------------------MLQKPR---G
R--------------------------------------------------GRPST----
-------QAD----------------------------PEPDWGGA--------------
----------GEE----------GPSTSRGA---------------GGSS-Q--------
------------------GSR---------A-SLSAPTVGPRTQKQLELKVAELV-----
-------QFLLIKDQKKIPIK-RTDIL--KHVVGDYR-----DVYPNLLKLAAER-----
----LQYVFGYK---------LVE-LEPKS---------HSYI-----------------
-------L----------------------------------INMLEPVEAD----AEMR
----GDQGTPISGLL-------MIVLGLIFMKGNT------ITET---EVWDFLRRL---
-----GVY-PTK----KHLIFGDPKKLITEDFVRQ------RYLEYRRI-PHTDPVDYEL
----QWGPRTNLETS--KMKVLKFVAKVHNQDPK----D-WPTQYCE---ALADEESRAR
PATA-SAPATSS------------------------------------------------
------------------------------------------------------------
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------------------------------------------

------------------------------------------------------------
------------------MSQ--LSKNLGDSSPPAEAPRLP-------------------
----------VYSRPTVLMRAP-----PASSRAPPVPWDPPPMDLQAASLPAWQAPQPAW
EAPQGQLPAPV---APLAQPPGLGGPLVQAPPLGGPMGKPPT------------------
---------------PGVLMVHHPPPPGAPMPQPPTPGVLMVHPS--GAPIAHPPP-PGT
PLA-----------------------------------R---------------------
-----P---------P------------------PPGTPM----A-------HPPPPGTP
------------------------MGHP--PPPGTPMAHPPPLGTPMVHPPPPGTPMAHP
PPPGTP--MA-------------------HPPPPGTPMAQP---PAPGVLMAQPLTPGVL
MVQPP-------------APGAPMPQPL---PPAALM-------------------TQPP
PSAASMAKPPGPSVLMMHPSASGAPITQPPVSG---------------APMGQPMAP---
----PAQPMASWGPQGQPVILQIQSQVI----R-------APPQV---P-----------
-------Q---GPQTPQVQLATTPGWQATSPGWQAPPQGWQATPLTWQTTQVT-------
------------WQAPPPM-RQGPPPIRR-------------GPPPIRPGPPPV------
------------------------------------------ARQVPSVTRQAPPVIRQV
-PP---------V-----------------------------------------------
--------IRQAPPLIRQAPP-PI------------------------------------
-----------------------------------------------------------R
--------------SGPQILATQPQLWQALPPPP-----P---------------LRQAP
QARLLAPQVQG------------APQVPTGPIVTQ-------VPAAPPAGPQVPQP---V
L--QAPLSVP----------------------------------------LPGPLP----
-GPQAAPSAVPRVPQ-------QAVH--CPSIIWQAPKGQALVPHE--------------
------------------------------------------------------------
------------------------------------------------------------
---------RPTSMEFQEVQQ-AQ-AL--AWQAPKAP-----THFWQPLPAQEAQGQ---
----PPRIFQLE-----Q-QPFRGALASQKGPQTQL-SPHQAQPM--GPQTEMPTMQLQP
SWQGPPPMLQTQPGAPVVGANFPRGQPKSLMTP-SGECRASSSEPKGSS-RE----RRTS
TK--EKKGPSKDRM----------IFAGTFYSPRA----VSVSRAHLPNAWKNLRATSDT
FSATSRVF-PST----SHFQPASSNAFTGPSATSE----SPKSLPFAL---QDPYACVDA
LPAVPWVPHPNGNVSKASKAEPKILM-ATAPSPQ----A-TATV-PE---TSNT-VEPPR
RS-----------------------GKV--------------------------------
--TRK-----KKHLEPEE-DKRGHRMT-------------------------------SQ
--N-WQGS----QLWGNSS--LSDW--EIQSSLQ-V--LGDWGCPSTSFGTNGWESSSMS
-RV---------------LSG---WEGPSTSWAQDPWEGPSTSR-G--------------
---------LGHC---------------EGSGNPQPFMASDVP-------------C---
LSHRLRATQENLRGE-TQQLSAL---DERANALVQ------FLLVRN-QTKVPI--QD--
------------------------------------------------------------
----SET---VNVITREYEDQCLDIISHANRKLTCNFGCQLNEIDTRTRSYI-IINKLGH
PQCDLL-ASFIDR-PKFG---LLM----------VVLSL----------IF--------M
-KGNC----V-R--ENLIFNLLFRLGLD--VRETNALFGNTKKLITEVFVRHK-------
---------YLEYRRIPCTEP---A--EYEFLWGPRAFLETSKMLVLRFLAKLHKR---D
------PQCWPFHYLEALAEFESEDSDEDE-PDV----SDDS-------DDP--------
---TSSAPPH--------------------------------------------------
------------------------------------------------------------
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--------------------------------------MRRA-P----------------
-----------------KRR-RYTLD-E----------------GLQS----QRE-EQE-
-------------RARAEVPEDEE------------------------------------
-----------------------------------------------------------E
D-AS-----------------------SSSSSCSSSFPSSFSSS----------------
-----------------------------------------------------------S
S-SSSSSCYPLV----SSN--PST--PEE---------------------AVG-------
---------ET--------------------------------------LSPP---QTP-
---PSACS---SSSVIT-S--TPR------------------------SS-QEEAGP---
------------S------NEQAVP------------PVEPSPRYIIDDRVGDLV-----
-------GFLLLKYRTKELTT-KAEML--SRIVEEYH-----NLFPVIFGEASEC-----
----MQLVFGIN---------VIE-VDPND---------HSYA-----------------
-------L----------------------------------ITNLDL-TYD----GIVD
---DE-HSLPKTGIL-------ILILCIIFMEGNR------VSEE---EIWEKLSFM---
-----GMH-DGR----EHCIYGEPRELLTNIWVQE------QYLEYRQV-PNSSPPRYEF
----LWGPRAHIETS--KMKVLEFLAKINDTEPR----S-FPLWYEE---ALRDEEERSQ
ARATIDD-TVA-------------------------------------------------
------------------------------------------------------------
-----------------------VA--------S----------------TSS----SA-
------------------------------------------------------------
---------MCS---------------------SFSC-----------------------
------------------HK----------------------------------------
------------------------------------------------------------
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--------------------------------------MPLEQ-----------------
-----------------RSQ-HCKPE-E----------------GLEA----RGE-ALG-
-------------LVGAQAPATEE------------------------------------
-----------------------------------------------------------Q
E-A---------------------------------------------------------
------------------------------------------------------------
----ASSSSTLV----EVT--LGE------------------------------------
---------VP--------------------------------------AAES---PDPP
QSPQGASS---LPTTMN-Y--PLWSQSYE----------------DSSN--QEEEGP---
------------S------TFPDL---------------ESEFQAALSRKVAELV-----
-------HFLLLKYRAREPVT-KAEML--GSVVGNWQ-----YFFPVIFSKASSS-----
----LQLVFGIE---------LME-VDPIG---------HLYI-----------------
-------F----------------------------------ATCLGL-SYD----GLLG
---DN-QIMPKAGLL-------IIVLAIIAREGDC------APEE---KIWEELSVL---
-----EVF-EGR----EDSILGDPKKLLTQHFVQE------NYLEYRQV-PGSDPACYEF
----LWGPRALVETS--YVKVLHHMVKISGGPHI----S-YPPLHEW---VLREGEE---
------------------------------------------------------------
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----------------------------------------------LTMKVGLLE-----
-------QFLLYKYKMKQPIV-KEDMM--NVIGQNYK-----NQYPEILKRASER-----
----IEVVFAVE---------LKE-VDSTR---------HSYD-----------------
-------L----------------------------------VSKVKL-PNN----GRVR
----AGRGLPKTGLL-------MTVLGVIFMKGNC------AAEE---DIWKFLEMR---
-----GK K-KSLNGKL------------------I----IQKEMSTWEK-QESK------
----IFCCPRGLRPLI--------------------------------------------
-SCL----LSV----T------LVSSCL--------------------------------
----------------------GD RRA-------------------------------SE
KRG------------------RARAEAQGEGAQ---------A----TVAVEE-------
------------------------ESTSS-SPPQSEDITQSLPP-AVSSSTFQGRRRAQA
---------ITIT------------------STANMCTRSDED-------------SNSQ
DEDRAS PFEVPYYTE-SAGEDSL---IRKPGLLEQ------FLLYKY-KMKQPI--LK--
------------------------------------------------------------
----EDM---LKIIGQNYEDQFPEILKKASERIEIVFAVDLKEIDSTKQSYD-LISKLKL
PNNGRV-RAGRGL-PKTG---LLM----------NILGM----------IF--------M
-KGNC----A-A--EEDIWKFL--------------GPKAQAE-----TSKMK-------
---------VLEFLAKVNDTI---P--SAFPSYYEEALKDEEKKVQTRAMVTAGTI---A
------KVLVPSRPMPQNIF------PP--------------------------------
------------------------------------------------------------
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---------------------------------------MSDT-----------------
---------------SE-SGT----------------------------GPTRFQAEASE
EDPG-LKMQTVL-------TVTQ--NLEASETPKGS------------------KT----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------PEVSKATKIS-------NAAGVS---------------KA------------
---------------------------------------------TEAQEVS-ATQASPT
-TKLTDTQFLAA----KK--KSLAADT--NMQHTDPQ-------AVTVPAT---------
----ETKK-----VSS--------------------------------------------
------------------------------------------------------------
--------------------------------------------------------VA--
-------------------------------DTKV-------------------------
----N-T--KTLETES--------TASQALADEP---------EP--EGAAGQAQENQDT
RPKIK--------------------A---------------------------------K
KARKVKHLNGEEDGS---------------SDQSQASGTTSGRRISKALMASMARRASRG
PIAFWARRAS----RTRLA----A------------------------------------
------------------------------------WARRALL----SLRSPKARRGKAR
RRA---------------------------------------------------------
-AKLQS-SQEPEAPP-PRDVALL---QGRANDLVK------YLLVKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LKDIIKEYTDVYPEIIERAGYSLEKVFGIQLKEIDKNDHLYI-LLSTLEP
TDAGIL-GTTKDS-PKLG---LLM----------VLLSI----------IF--------M
-NGNR----S-S--EAVIWEVLRKLGLR--PGIHHSLFGDVKKLITDEFVKQK-------
---------YLDYVRVPNSNP---P--EYEFFWGLRSYYETSKMKVLKFACKVQKK---D
------PKEWAAQYREAMEADMKAAAEAAA--EAKAR----AEIRAQMGIGLGSE-----
----NAAGP--CNWD-------------EADIGPWA-KARIQAGAEAKAKAQESG--GAS
AG------------------AS----A--GGNFGASTSLTATLTFGLFAGLGGAGASASG
SSGACG-FSYK-------------------------------------------------
------------------------------------------------------------
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--------AAP-----------QVRAAPQVQAAPQAPKGQPPVPHE--------------
------------------------------------------------------------
------------------------------------------------------------
---------LPTSMEFQEVQQ--------TWPAPKTP-----AHFWQPLPAQEVERQ---
----GPQLVQLE-------QPFQGAPPSQKVLQIQL-PTQQAETSGSGSQAELPPLQLQP
SWQAPPGAMQAQSAASLGAANFHRGSAKSLMTPPSGESKASSVDPRASS-KE----RRTS
SK--ERRTPSKDRM----------IFAGTFCAPRA----VSTARAYLPTAWKNPPGTSET
FTATSRVF-PAT----SPIYPASSVTFKGPTVTSE----TPKSLPLAL---QNPFACEEA
LPAVSWVPQPNSNASKAWKSAPTFLM-ASAAVPR----A-TATN-DE---VSKTS--QQR
RS-----------------------GKV--------------------------------
--ARK-----KKHLNAQE-DSSGHMLA-------------------------------LH
--D-WQAP----RPWSNLN--LSDW--EVQSPLQ-V--LGDWEGLSVSCGLSGWEGPSTS
-RI---------------LSG---WEGPSTSWALNAWECPSTSR-V--------------
---------LSVW---------------ESSGKPEPLIFSEVP-------------S---
LSQELGATQAEPKLE-TQPLSPL---DERANALVQ------FLLVKE-QAKLPI--KR--
------------------------------------------------------------
----SEM---VKVIIREYKDECLDIINRASHKLECAFGYQLKEIDPKNHSYI-IINKLAH
RKYEPV-ASYLDT-PKLG---LLM----------VVLSL----------IF--------M
-RGNC----V-K--DHLVFDFLTKLGLD--NGETHGFFGNTKKLITEVFVRQR-------
---------YLDYRRVPYTEP---A--EYVFLWGPRAFLETSKMLVLRFVARLHKR---D
------PQCWPFHYLEALAECEAEDLEDDE-AEA----GDNA-------GGP--------
---TSSSPPR--------------------------------------------------
------------------------------------------------------------
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--------------------------------------MPHGQK---SKHCAREKR-HQA
-RA-----ETQGL-----------------------------------------------
-HD--------------QATTSRG------------------------------------
-----------------------------------------------------------E
-ETT-------------------------SSSPP-----D---------------SESTP
SSWS-A-------------------------AGT----------------ATEPQG---A
Q--GTTSAAAGAIRKRSGVGGT--------------------------------------
------------------------------------------------------------
--------ARSRSAVPGTA----CSRSGVGA---------------EG-Q-VQEGE----
-----------------------------NS-SQASAAAASSHTDLLTRKAEILV-----
-------QYMLFKYKMRELIK-RSEML--QEINRRYK-----EQFPEILSRASEH-----
----MELVFGLV---------LKE-VRPNS---------HCYT-----------------
-------L----------------------------------VSHLDL-SAS----ESMR
----GDRGLPKNGLL-------MPLLGVIYLNGNH------APEE---KIWKFLNML---
-----GIY-DGR----SHFIFGEPRKLITEDLVRE------EYLEYRQV-PGSDPPRYEF
----LCGPKALTETG--KMKVLQFLAKVKDSVHP----A-LQPQYEE---AWREEVESTG
ARGAA-RA-------------G---TSASTRPG---------------------------
-----------------------TAA----------------------------------
-S--------------------ASAGTSASATVHP-----RAA-------SNRSSRP---
------------------------------------------------------------
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------------------------------------------

------------------------------------------------------------
------------------MSL--VSQNSRRRRRRVAK---ATA-----------------
----------H-NSSWGEMQAPNAPGLPADVPGSDVPQGPSDSQILQ-GLCAS-------
---EG-----------------PST------------SVLPT------------------
---------------SAEGPST---------FVPPTIS---EASSASGQPTI-SEG-PGT
SVLPTP---------------S-EG----LSTSGPPTIS---------------------
-----KGLCTSVTLAASEGRN------TSRPPTSSEEPST---SV-------PPTASEVP
-S----------------------TSLPPTPGEGTSTSVPPTA--------YEGPSTSVV
PTPDEGPSTS-------------------VLPTPGEGPGTS-------VP--LAATEGLS
TSVQATPDEGPS--------TS---VP-----PTATEG------------LST---PVPP
T------RDEGPSTSVPATPGEGPSTSVLPAAS---------------DGQSIS------
------------------------------------------------------------
------------------------------------------LVPTRGKGSSTSVPPTAT
EGLSTSV---------QPTAGEGSSTSVP---------------PTPGGGLS--------
---------------------------------------------------------T--
------------------------------------------------------------
------S---------VPPTAT--------------------------------------
-----------------------------------------------------------E
ELST--------------------------SVPP-----T---------------PGEGP
ST-SVLP-IPG------E-GLS-TSVPPT-ASD-GS--D---T-SVP---PT-PGE----
G--ASTLVQP----------------TAPDGP--------------GSSVLPNP------
---GEGPSTLFSSSA-----SVDRNPSKCS-LVLPSPRVTKA------------------
----------------S------VDSDSEGP---------------K-------------
-------GAEGPIEFEVLRDCESPNSISIMGLNTSRVAITLKPQDPMEQNVAELL-----
-------QFLLVKDQSKYPIR-ESEMR--EYIVKEYR-----NQFPEILRRAAAH-----
----LECIFRFE---------LRE-LDPEA---------HTYI-----------------
-------L----------------------------------LNKLGPVPFE-----GLE
----ESPNGPKMGLL-------MMILGQIFLNGNQ------AKEA---EIWEMLWRM---
-----GVQ-RER----RLSIFGNPKRLLSVEFVWQ------RYLDYRPV-TDCKPVEYEF
----FWGPRSHLETT--KMKILKFMAKIYNKDPM----D-WPEKYNE---ALEEDAARAF
AEG---------------------------------------------------------
------------------------------------------------------------
----WQALPHFRRPFFEE----------AAAE------------------VPS-PD----
-SE---------------------------------------------------------
---------VSSY-------------------------S---------------------
---------SKYAPH-SWPESRL---ESKARKLVQ------LFLLMD-STKLPI--PK--
------------------------------------------------------------
----KGI---LYYIGRECSKVFPDLLNRAARTLNHVYGTELVVLDPRNHSYT-LYNRREM
EETEEI-VDSPNR-PGNN---FLM----------QVLSF----------IF--------I
-MGNH----A-R--ESAVWAFLRGLGVQ--AGRKHVI--------TCRYLSQR-------
---------YIDSLRVPDSDP---V--QYEFVWGPRARLETSKMKALRYVARIHRK---E
------PQDWPQQYREAMEDEANRADVGHR-QI----------FVHNFR-----------
------------------------------------------------------------
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--------------------------------------RGRAA--------SQ-----G-
-LPERDCTASVE------------------P---------------GPSA-TPP------
------------------MPSTSSSSS--TS-SQAQKKPAKRTEAQIQQKVNELV-----
-------QFLLVKDQKKVPIR-RADMV--KTVLQDYK-----DMASVIIERAGQT-----
----LEEVFGLQ---------LTE-IDRKH---------HAYI-----------------
-------L----------------------------------INKLERLEGD-----GMK
----ADEGVAKMGLL-------MVILSLIFMKGNS------ARES---LVWDVLKKL---
-----RVD-PEK----RHKTFGDVKKLVKDEFVRQ------KYLEYIRV-PHSEPPEYEF
----LWGPRAAHETS--KMQVLRFVAKIQNREPS----S-WVSQYNE---ALQDELASAS
ASAS-ASASSG-------------------------------------------------
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--------------------------------------HPGG-Q----------------
-----------------KDP-QSSPD-Q----------------LPQT----HSE-TQG-
-------------LEVAQESKALE------------------------------------
-----------------------------------------------------------E
A-----------------------------------------------------------
------------------------------------------------------------
---SLS-SHPEM----PGN--LKEA---P---------------------DAA-------
----------I--------------------------------------PSTS-------
HSAQSSSS---SV--------SSSRKYGE----------------GSSS--EEEEED---
------------S------TLEADP------------DPKNVPVDAEDENVASLV-----
-------NFLLLKYQTKEIIT-KEDIL--QIISQEYK-----DHFAEMFLRASER-----
----LEIIFGLE---------VKE-VDPTN---------HCYA-----------------
-------I----------------------------------VIKLGL-TYD----GMQH
---GK-VGVPKTGIL-------ILILAVIFMKGNR------ATEQ---EIWDVLKVT---
-----GVY-SGR----KHHIFGEPRKLITKYFVKE------DYLKYQQV-PNSDPARFEF
----LWGPRAIAETT--KMQVLEFMAKVHGIDPS----S-FPSQYED---ALQDEKDRAQ
ARN---------------------------------------------------------
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--------------------------------------MPRGQK---SKLRAREKR-RQV
-RN-----ETQGL-----------------------------------------------
-AS-------------AQAIAAE-------------------------------------
-----------------------------------------------------------E
GES--------------------------TSAGP-----L---------------SGGKP
ENLP-D------------------------AEMPS-------T-------PTEPKG---T
P--STTNTTA-A------------------------------------------------
------------------------------------------------------------
-----------------VS----CANSGEGA---------------ND-Q-DE-ESS---
------------------------------K-S--SNSSEHFHRDPLNKKVVLLV-----
-------QFLLQKYQNKEPIM-KTDMI--KLVNKKYK-----VHFNEILKRASEH-----
----MELAFGVD---------LKE-VDPIR---------HCYA-----------------
-------L----------------------------------VNKLDI-AFD----ASVN
----EEENMPKTGLL-------MIVLGVIFMKSNC------ATEE---EIWEVLNMM---
-----GVY-ADR----KHFIYGDPKKVLTEDLVQL------KYLQSRQV-PDSDPPRLEF
----LWGPRAHAETS--KMRVLEFLAKIHDTIPS----A-FPAWYEE---ALRDEEERAR
AR-AAAKARIA-AM----------------------------------------------
----------------------------------------------------------AK
--------------------ARS--E-----------------------ALAS-SSSPTK
------------------------------------------------------------
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---------------------------------------MSDT-----------------
---------------SE-KGT----------------------------GPTRFQAEASE
KDSG-LKIQSLL-------TVTQ--NSEVSETQKTS------------------KA----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------PEVS----------------------------------KAT-----------
-------------EV---------------------------SKTPEVRETA-ATQASPT
-TKLTDTQVLAA----EK--KSLAADT--KMQSADPQ-------PVTLPAT---------
----ETKK-----VSC--------------------------------------------
------------------------------------------------------------
--------------------------------------------------------VA--
-------------------------------NTKV-------------------------
----N-I--KAQEPED--------PASQALADEP---------KP--EGAAAQVQENQDT
RPKVK--------------------A---------------------------------K
KARKVKPLNGEEDGS---------------SDQSQASGTTAGRRVSKALMASMARRASRG
PIAFWARRAS----RTRLA----A------------------------------------
------------------------------------WARRALL----SLRSPKARRGKAR
RRA---------------------------------------------------------
-AKLQS-SQEPETPP-PRDVALL---QGRANDLVK------YLLVKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LKDIIKEYTDVYPEIIERAGYSLEKVFGIQLKEIDKNDHLYI-LLSTLEP
TDAGIL-GTTKDS-PKLG---LLM----------VLLSI----------IF--------M
-NGNR----S-S--EAVIWEVLRKLGLR--PGIHHSLFGDVKKLITDEFVKQK-------
---------YLDYARVPNSNP---P--EYEFFWGLRSYYETSKMKVLKFACKVQKK---D
------PKEWAAQYREAMEADMKAAAEAAA--EAKAR----AEIRARMGIGLGSE-----
----NAAGP--CNWD-------------EADIGPWA-KARIQAGAEAKAKAQESG--GAS
SG------------------ASASASA--SGGFGASASLTATLTFGLFAGLGGAGASTSG
SSGACG-FSYK-------------------------------------------------
------------------------------------------------------------
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-------------------------ML--TNVISRYT-----GYFPVIFRKAREF-----
----IEILFGIS---------LRE-VDPD----------DSYV-----------------
-------F----------------------------------VNTLDL-TSE----GSLS
---D-EQGMPQNRLL-------ILILSIIFIKGTY------ASEE---VIWDVLSGI---
-----GVR-AGR----EHFAFGEPRELLTKVWVQE------RYLEYREV-PNSSPPRYEF
----LWGLRAHSEVI--KRKVVEFLAMLNNTVPI----T-FPSSYKD---ALKDVEERAQ
AIIDTTDDSTA-------------------------------------------------
------------------------------------------------------------
-----------------------TE--------S----------------ASS----SV-
------------------------------------------------------------
---------VSP---------------------SFSS-----------------------
------------------E-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------

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------------------------------------------------------------
---------------------------------------MSDT-----------------
---------------SE-SGA----------------------------GLTRFQAEASE
KDSS-PMMQTLL-------TVTQ--NVEVPETAKAS------------------KA----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------LEVSEDVKVS-------KASGVS---------------KAT-----------
-------------EV---------------------------SKTPEAQEAP-ATQASST
-TQLTDTQVLAA----EN--KSLAADT--KKQNADPQ-------AVTMPAT---------
----ETKK-----VSR--------------------------------------------
------------------------------------------------------------
--------------------------------------------------------VA--
-------------------------------DTKV-------------------------
----N-T--KAQETEA--------APSQAPADEP---------EP--ESAAAPSQENQDT
RPKVK--------------------A---------------------------------K
KARKVKHLDGEEDGS---------------SDQSQASGTTGGRRVSKALMASMARRASRG
PIAFWARRAS----RTRLA----A------------------------------------
------------------------------------WARRALL----SLRSPKARRGKAR
RRA---------------------------------------------------------
-AKLQS-SQEPEAPP-PRDVALL---QGRANDLVK------YLLAKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LKDIIKEYTDVYPEIIERAGYSLEKVFGIQLKEIDKNDHLYI-LLSTLEP
TDAGIL-GTTKDS-PKLG---LLM----------VLLSI----------IF--------M
-NGNR----S-S--EAVIWEVLRKLGLR--PGIHHSLFGDVKKLITDEFVKQK-------
---------YLDYARVPNSNP---P--EYEFFWGLRSYYETSKMKVLKFACKVQKK---D
------PKEWAAQYREAMEADLKAAAEAAA--EAKAR----AEIRARMGIGLGSE-----
----NAAGP--CNWD-------------EADIGPWA-KARIQAGAEAKAKAQESG--SAS
TGASAST------NNSA--S--ATAST--SGGFSAGASLTATLTFGLFAGLGGAGASTSG
SSGACG-FSYK-------------------------------------------------
------------------------------------------------------------
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--------------------------------------------------PK-------D
P--LTGKV----------------------------------------------------
------------------------------------------------------------
--------------GLL---------------------------------------V---
------------------------------Q-F---MLYKYKLKE---PIK---------
----------------------KAEML--KIINKRYR-----EHFPEIFKRTSER-----
----MELVFGLE---------LKE-IKPGG---------HSYT-----------------
-------L----------------------------------MSTLNL-TSD----SDVS
----NGWGFPKNGLL-------MPLLGVIFLNGNC------TSEE---GIWEFLNIL---
-----GIY-DGK----RHFIFGEPRKLITQDLVQE------KYLEYRQV-SGSDPPRYEF
----LWGPRAHAETS--KMKVLEFLAKVHDTVPS----V-FLPHYEE---ALRDEEERAQ
A-EPRLRL------------------PL--LPR---------------------------
----------------------PVRSN-------------------------------A-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------G-------------AKSR
VDGGKHSSQASTSPE-SARNDLL---TRKVGILMQ------FMLERY-AMKAPI--IR--
------------------------------------------------------------
----AEM---LKIINKRYKEDFPEIFGKASEHLELVFGLELKEIKPSGHSYT-LVSSLDI
TSDGDV-SNGWGP-PKNG---LLM----------PLLSV----------IF--------L
-SGNR----A-S--EEDIWEFMNILGVY--EGRKHVVFGEPRKLITQDLVQEK-------
---------YLEYRQVSGSDP---P--CYEFLWGPRAHAETSKMRVLEFLAKVHDT---V
------PSAFPFHYEEALRDEEERA-----------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------MSQ--LSTNPGDSSPPD-SPLPPVQ-----------------
----------VHSRPTVLMRAP-----PASSRAPPVPWDPPPVDLQA-PLASWQAPQPAW
EAPEGQLPAPV---AQLAQPPSLGAPMVQAPPLGGPMTQPPT------------------
---------------PGVLMLHP-SVPGGPLAHPTTPGTQMTHPQ---------------
-----P-------------------------PPGTPMAH---------------------
-----PLPGTPMAHPP----------------PPPPVTPM----A-------HPPPPGTS
------------------------MGHP--L----------VPGNPMVHHLTPGAPMVHP
PQPGTS--IP-------------------HAAI---PGTQP---PTPGVLMAQQLSPGVL
MVQPT-------------APGAPMVQPP---PQATLM-------------------TQPS
SSITQMAKPPGPGVVMIHPPGARAPNIQTPVSG---------------APTAQPVLP---
----PGQPLASWAPQSQPLILQIQSQLM----R-------TPQQV---P-----------
-------P---IPSTPQVQLATAPGWQATTPNWQVTPQGWQGTPLAWQTTQVTWQTPT--
----------LAWQT-PPV-RQGPSPIRS-------------GPTPIRPGPPPP------
------------------------------------------------VLRQMPPVVR--
------------------------------------------------------------
----------QTPPLTRQTTAAPI------------------------------------
-----------------------------------------------------------R
--------------QPLPGIASQPPLWMPGP-----------------------------
---------------------------QTAPQVTQ-------IHLVPQTGPQVSHP---M
L--SAPLSIP----------------------------------------IPVP------
-------QAASQSAS-------RAVH--CPSIIWQATRGQRQVPEEL----EV---PQEL
QMPEELEVPQEVEVPEELQ----VPQEVEVP---------------EELQ-ESEEVP---
----------VPQEVPVEREVQVPQQ------LQVPQELPVPQEVQVPQEVPVPQQLQVP
-RELPVQQERPVSLEFQEVQQ-AQ-AM--GWQAPKVP-----THFWQPASAQEAQEQ---
----ATPRTRVE-----QQQPFQGVQPSRKVLQTRR-AAHQAQPA--GMQAEQPSNQLQP
SWQGPAPTMQVQRGASRARTNFPRGSTRSLMT-PSGEPGPSSLEPRGPP-RD----RRGS
SR--GRRGPPKDRM----------IIGATFCAPRS----ASASRAYLPTAWGNVPATSET
LTATSRVF-PST----SHFQPASSNGFRGPSATSE----SPKSLPFAL---QDPYACVEA
LPAVPWVPYADVNSSSACKAVPTILM-VTAAAPE----A-SATI-AE---ASKS-AEPPR
RS-----------------------GKA--------------------------------
--TRK-----KKHLEPKE-DNGGQRMA-------------------------------SR
--D-WRGP----RPCENPR--QNDW--EMQRAMQ-L--LGEQEPLYTSQGLNGWGRPNNS
-RI---------------PRG---FDGP------------STSQ-D--------------
---------QRFC---------------GGSGGSQPWMVSEVP-------------S---
VSRGSSAVQEDPNGE-SQALSPL---DERANALVQ------FLLVKD-QARVPV--QL--
------------------------------------------------------------
----SEM---VNAVIREYKDDSLDIISRANAKLESSYGCQLKEIDTKTHTYI-IVKKTGH
PQCNML-TSYLDR-PKFN---LLI----------VVLSL----------IF--------M
-KGYC----I-R--ENLLFSFLFQLGLD--VHATSGLFRSTKQLITSVFVRHR-------
---------YLEYRQIPFTEP---A--EYELLWGPRAFLEANQMHIFRFLASLYEN---Q
------AQIWTGQYLQSLAQLEYTNTN-----EEPNDSDDDS-------HGT--------
---TSSAHPH--------------------------------------------------
------------------------------------------------------------
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--------------------------------------MPRGHK---SKLRAREKR-RQA
-RA-----KNAQ------------------------------------------------
--E-------------EEASPGPF------------------------------------
-----------------------------------------------------------Y
-GCP-------------------------H------------------------------
QAIP-G-------------------------ASM----------------PTSPNM---P
M--GE-------------------------------------------------------
------------------------------------------------------------
--------------QSTFS----HSYASTSD---------------QN-L-DE-------
-----------------------------KS-SDDSEDTEDWCKDPINHNVVLLV-----
-------QFLMEKYRKKEVIT-KADML--KYVVKTSK-----NHFNEILKRASEH-----
----MELAFGID---------LKE-VDPTR---------HCYA-----------------
-------L----------------------------------FNKLEH-TFD----GVMG
----E-EKMPSSGLL-------MIVLGVIFMNDNC------VSET---EIWNVLSMM---
-----GVY-ANR----KHFIYGDPKKVITEDMVQL------KYLEYQQV-PNSNPPSFEF
----TWGPRACAEIS--KMKILEFWAKIHDTTPD----S-FPTLYEA---ALKDEEERAQ
ARAI-ARA----------------------------------------------------
-----------------------------------------------------------H
--------------------TAAMA------------------------------SP---
------------------------------------------------------------
------------Y-----------------------------------------------
------------------SRAAM---CSSS--HTN------I------------------
------------------------------------------------------------
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---------------------M-------SLVSKNACH----------------------
------------------------------------------------------------
------------------RSAETT------------------------------------
-----------------------------------------------------------A
-DY---------------------------------------------------------
-----------------------------------------------------------S
D--FHGEMQA----------------TDASGL------------P-V-------------
---------------------------------------------------SM------I
----------VPDAPQ----GPQAPVDPQVA---------------SASQ-AA-------
---------QDP----K--DLDV--LID-EQSRRLGA---LRVHDPLEDRSIALV-----
-------NFMRMKSQIEGSIQ--QTEM--LEFLREYS-----DQFPEILRRASAH-----
----LDRVFGLN---------LRV-LDPQA---------DTYN-----------------
----------------------L-------------------ISKRGL-QTN----DWIA
----ESLDMPKAGLL-------ALVLGHILLNGNR------ARET---SIWDLLLKV---
-----DVL---GEPQRINIPFGNTRNLLTTDFVRM------RFLEYWPV-YGTNPLEFEF
----LWGSRAHK--EITKM-----------------------------------------
------------------------------------------------------------
--------------------------E-------------------------------AL
K-----------------------F---VA----------------EAHDEEP-------
------------------------WSWPE-EYN------------KALEADKAKER---S
---------------------------------------------------------QA-
AG---L--------E-FWSED---TMNDKANDLVQ------LAINVT-EELLPI--HQ--
------------------------------------------------------------
----DEL---LAHTGKEFEDVFPNILSRATLILDLFYGFSLIEVDTSEHIYL-LVQQPES
EEEQMM-LESLGR-PTQE---YVM----------PILGL----------IF--------L
-MGNR----V-K--EANVWNLLRRFGVD--VGRKHAI--------TCKLMRQR-------
---------YLECRPLSYSNP---V--EYELLWGPRAHLETTKMKALEYMARLYRK---Q
------PQDWPEQYREAVE-----------DEEARARSEATAMFF----FGP--------
---M--------------------------------------------------------
------------------------------------------------------------
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--------------------------------------MSLEQ-----------------
-----------------RSP-HCKPD-E----------------DLEA----QGE-DLG-
-------------LMGAQEPTGEE------------------------------------
-----------------------------------------------------------Q
E-T---------------------------------------------------------
------------------------------------------------------------
---TSSSDSK--------E--EEE------------------------------------
---------VS--------------------------------------AAGS---SSPP
QSPQGGAS---SSTSVY-Y--TLWSQFDE----------------GSSS--QEEEEP---
------------S------PSVDPA------------QLEFMFQEALKLKVAELV-----
-------HFLLHKYRVKEPVT-KAEML--ESVIKNYK-----HYFPVIFGKASEF-----
----MQLIFGTD---------VKE-VDPAG---------HSYI-----------------
-------L----------------------------------VTALGL-SCD----SMLG
---DG-HSMPKAALL-------IIILGVILTKDNC------APEE---VIWEALSVM---
-----GVY-VGK----EHIFYGEPRKLLTQDWVQE------NYLEYRQV-PGSDPARYEF
----LWGSKAHTETS--YEKVINYLVMVNGREPI----C-YPSLYEE---VLGEEQEGV-
------------------------------------------------------------
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--------------------------------------MSLEQ-----------------
-----------------RSQ-HCKPE-E----------------GLEA----QGD-ALG-
-------------LVGAQAPATEE------------------------------------
-----------------------------------------------------------Q
E-I---------------------------------------------------------
------------------------------------------------------------
----ASSSSTVV----EVT--QGE------------------------------------
---------VP--------------------------------------AAES---PGPP
QAVLREPP---PSP-------------------------------LPTT--HTLEVP---
------------S------TFPDL---------------GPASRQ-HSVGGAELV-----
-------HFLLLKYRAREP------------VMRNCQ-----YFFPL-------------
-------VFGIE---------LME-VDPVG---------HLYI-----------------
-------F----------------------------------VTCLGL-SYD----GLLG
---DN-QIMPKAGLL-------IIVLAIIAKEGDC------APEE---KIWEELSVL---
-----EVF-DEK----EDSIFADPRKLLTQDFVQE------NYLEYRQV-PGGDPACYEF
----LWGPRALLETS--YVKVLYHMLKISGGPHF----S-YPPLHEW---ALREGEE---
------------------------------------------------------------
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---------------------------------------MSDR-----------------
---------------SE-SGA----------------------------DVTCFQAEAAE
EDNS-LVMQTLL-------AVTQ--NLEVSELPKAS------------------KA----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------PEVSEALKVS-------NAPRCL---------------KDT-----------
-------------GV---------------------------SKAQEAQEGA-FTHTSPT
-TQLTDTQVLAA----KN--KSPAAV-----TNADLQ-------AVPVPGT---------
----ETKL-----VSC--------------------------------------------
------------------------------------------------------------
--------------------------------------------------------IA--
-------------------------------DTQL-------------------------
----N-T--KTLETEA--------AASQASTDEP---------EP--EGAAAETQENQDT
RPKVK--------------------A---------------------------------K
KARKVKHLSGEEDRS---------------SDQSQVSGNTGGRRVSKALMASMARRASRG
PIAFWARRAS----RTRLA----A------------------------------------
------------------------------------WARRALL----SLRSPKAHRGKAR
RRA---------------------------------------------------------
-AKVQS-SQEPEAPA-PRDVALL---QGRANDLVK------YLLVKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LNDIIKEYTDVYPEIIERAGYSLEKXXXXXXXXXXXXXXXXX-XXXXXXX
XXXXXX-XXTKDS-PKLG---LLM----------VLLSI----------IF--------M
-NGNR----S-S--EAVIWEVLRKLGLR--PGVHHSLFGDVKKLITDEFVKQK-------
---------YLDYTRVPNSNP---P--EYEFFWGLRSYYETSKMKVLKFACKVQKK---D
------PKDWAAQYREAMEADLKAAAEAAS--EAKAR----AETRAQMGIGVGSE-----
----NAAGP--CNWD-------------EADIGPWA-KARIQAGAEAKGKAEESG--GTS
AGT--------------------STSA--SGSFNASSSLTATLTFGLFAGLSGAGTSTNV
NSGACG-FSYK-------------------------------------------------
------------------------------------------------------------
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--------------------------------------MDNPH-----------------
-----------------NIL-HCNLQ-G----------------SAQG----QRE-----
-------------LDNAQAP----------------------------------------
------------------------------------------------------------
--------------------------------------MV-I------------------
------------------------------------------------------------
---DEEE-VTLA----SRK--V--------------------------------------
----------C--------------------------------------GSGI---PSLP
QSPQRASS---PSVALA-S--IPEG------------------------P-SEEAST---
------------N------QVEDLE------------DPLRMFYNALNIKVYDLV-----
-------DFLLFKYQMKAFTT-KAEML--ESIGREYD-----QYFSLIFSEASEC-----
----MKLVFGID---------MIE-VDPFV---------HSYI-----------------
-------L----------------------------------VIALGI-TYD----GM--
LT-DV-QGMPKTGLL-------IVVLGVIFMQGNC------VSED---IIWEMLNNI---
-----GLY-GGR----DAYIHQDPRKLISEEFVQE------GYLEYRQV-PNSDPHSYQF
----LWGPRAFVETT--KMNVLKFFASITKTDPR----A-FTEKYAE---ALRDEIERAQ
AWIAQEIAL---------------------------------------------------
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---------------------------------------MDRRNDYGYRLPPFQ--G---
--------PLPPP--GSLGLP----------------------------FPPDIQTETTE
EDSV-LLMHTLL-------AATK--DPLAMDPPVVNRPKK-------------SKTKKAP
IKAI----------TKA-APA--APPVPTASEIATKQPKITLQALNLPVITQISQASPT-
T------------------------------------------------EVAN-------
------TQASSVTSQSKKANKMKRVTAKSAQG-SQSPAGYEGVTTQLKSPLQVLNLPVIS
QNIHV---PIANESASSQAL-ITSIKPKKAF---------------KAK-----------
-------------KVA----------------NKAIASATEVSLAANATHTA-ITQGQIT
-SETASIHTTAASIRTKKASKAKKTTA--KVINTDTE-------HAEARNV---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------TEAAT
RQIEA--------------------S---------------------------------V
VAIRSKKSKGKKAASRGP---------N------------SLSEISEAPLATQMVTNQAL
AATLRVKRGS----RARKA----ATKSRATESQT----PVADQGSQAKMATAQ-TNVSAL
QTQ------------VA------------AAVQALADDCLAQL----SLEPTTRTRGKRN
RK-----------------------------------------------SKHLNGDERS-
GSNYRRIPWGWRPAP-PRDVAIL---QERANKLVK------YLLVKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LRDVIQEYDEYFPEIIERASYALEKMFRVNLKEIDKQSSLYI-LISTQES
SAG-IL-GTTKDT-PKLG---LLM----------VILSV----------IF--------M
-NGNK----A-S--EAVIWEVLRKLGLR--PGVRHSLFGEVRKLITDEFVKQK-------
---------YLEYKRVPNSRP---P--EYEFFWGLRSYHETSKMKVLKFACKVQKK---D
------PKDWAVQYREAVEMEVQAAAVAVA--EAEAR----AEARAQMGIGEEAV-----
------AGP--WNWDDMDIDCLT-REELGDDAQTWS-RFSF----EIEARTQENADASTN
VNFSRGASTRAGFSDGASISFNGAPSS--SGGFSG-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------GPGITFGGAPSTSASFSSTASISFGGTVNTSS----------------
--------------------SFS------------------N----------------AA
SISFGGAPSTSTSFSSEASISFGGMPCTSASFSGGVSSGFSGPLS--TSATFSGGTNSGF
GG------------------IL-STTAGFSGVLSTSTGFGSAPTTSTVFSSALSTSAGFG
GTLSTSVCFGGSPSSSGSFGGTLSTSICFDGSPCTSTGFGG----TLSTSVSFGGSSSTS
ANFGGTVSTSICFDGSPSTG-AGFGGALNTTASFGGALNTSA------------------
-------------------------------------------------AGFGGAMSTCA
DFGGTLSTNVCFGGSPCTSVSFGGALNTNAGFGGAISTSTDFGG----------------
------------------------------------------------------------
-----ILSTSVC------------------------------------------------
----------------------FGGSPSTSAGFGGALNTNASFGCAVSTGAGFSGAVSTS
AGFSGAPSANSGFGGAFSTSAGFSGALSTATDFGGTPSNSIGFGAAPSTSVSFGGAHSTS
LCFGGAPSTSLCFGSASNTNLCFGGPPSTSACFSGATSPSFGDGPSTSTGFSFGNGLSTS
AGFGGGLSTS--------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------

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------------------------------------------------------------
--------------------------------------MPRGQK---SKLRAREKR-RQA
-RS-----EPQDL-----------------------------------------------
-SV-------------AQAFAAEG------------------------------------
-----------------------------------------------------------K
-EIP-------------------------SSSSA-----I---------------NKGAS
QSTP-A-------------------------ASG----------------PGKSGK---G
R--ST-R-----------------------------------------------------
------------------------------------------------------------
----------------------------SGA---------------KS-Q-DE-ERP---
-----------------------------ST-SSA--LPQSLGNDPLTRKTGMLV-----
-------QFLLEKYKMKEPIR-RSDML--KLMNKKFR-----EHFPEILRKTTER-----
----MELVFGLE---------LKE-VDPKG---------RYFE-----------------
-------L----------------------------------SGKLSL-TSE---VGQ-S
----DGRGFPKNGLL-------MPLLSVIFMNGNR------ASEE---EMWEFLNVL---
-----GIY-DGI----KHFIFGEPRQLITKDLVQE------KYLEYQQV-PGSDPPRYEF
----LWGAKAHAETS--KMKVLEFLAKVNNTVPS----S-FQSRYEE---ALRDEEARAR
VS-ITAGARAT-AQAS--------------------------------------------
------------------------------------------------------------
--------------------TSA--T-----------------------ARAS-TSATAR
AS----------------------------------------------------------
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---------------------M-------SLVSQNARH----------------------
------------------------------------------------------------
------------------GSAETT------------------------------------
-----------------------------------------------------------A
-DY---------------------------------------------------------
-----------------------------------------------------------S
D--GRGEMQA----------------TNASGP------------P-T-------------
---------------------------------------------------SM------L
----------VPDTLQ----GSQVPMDPQGA---------------SASQ-AI-------
---------QDP----N--DIEV--LID-EQSRRLGA---LRVHDPLEDRSIALV-----
-------NFMRMKSQTEGSIQ--QSEM--LEFLREYS-----DQFPEILRRASAH-----
----LDRVFGLN---------LRV-LDPQA---------DTYN-----------------
----------------------L-------------------ISKPGP-QTT----DRLA
----ETLDVPKAGLL-------ALVLGHILLNGNR------AREA---SIWDLLLKV---
-----DVL---DEPQRINNLLGNTRNLLTTDFVRM------RFLEYWPV-YGTNPLEFEF
----LWGSRAHR--EITKM-----------------------------------------
------------------------------------------------------------
--------------------------E-------------------------------AL
K-----------------------F---VA----------------EAHDEEP-------
------------------------WSWPE-EYN------------KALEADKAKER---S
---------------------------------------------------------QA-
AG---L--------E-FWSED---TMNDKANDLVQ------LAINVT-EELLPI--HQ--
------------------------------------------------------------
----DEL---LAHTGKEFEDVFPNILSRATLILDLFYGFSLIEVDTSEHIYL-LVQQPES
EEEQVM-LESLGR-PTQE---YVM----------PILGL----------IF--------L
-MGNR----V-K--EANVWNLLRRFSVD--VGRKHAI--------TCKLMRQR-------
---------YLECRPLSYSNP---V--EYELLWGPRAHLETTKMKALEYMARLYRK---R
------PQDWPEQYREAME-----------DEEARARSEATAMFF----FGS--------
---M--------------------------------------------------------
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------------------------------------------------------------
--------------------------------------MDPTE-----------------
-----------------NSQ-SFNLP-V----------------SPQA----QRE-ARG-
-------------LESAQVP----------------------------------------
------------------------------------------------------------
--------------------------------------IAEA------------------
------------------------------------------------------------
---REAEATATT----PGD--M--------------------------------------
----------S--------------------------------------AGGM---LSSP
QSAQRASS---PPTVMG-G--AS----------------------------SAEASG---
------------N------PEGEVA------------EPEFPPQAVLNGRIVALV-----
-------RFLLTKFRRMELAT-KSEMM--QRAMRDYE-----EYYPVIFSKASEC-----
----MKLIFGID---------MME-VDPFV---------HSYF-----------------
-------L----------------------------------FPALGI-TYD----GL--
MH-GV-LGVPKTGLV-------IIVLCIIFIEDNC------VSEE---VFWDVLNSL---
-----GLY-ADM----DHFIFGEPKSLITEDFVQE------GYVEYRQV-PNSHPPRYEF
----LWGPRAYAETT--KMKVLEFYASIVKQDPR----S-YSEKYAE---ALREEQERA-
------------------------------------------------------------
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--------------------------------------------------RKHVAE---T
R--------------------------------------------------GRGCP----
-------QAE----------------------------AEKDGGHDGETQTGP-----P-
-RWRR-------------------------------------------------------
---------------------PRAPSC--RR-APAKALARRRLHRRLNRTVAELV-----
-------QFLLVKDKKKSPIT-RSETV--KYVIGDLK-----DLFPEIVAGAAEH-----
----LRYVFGFD---------LKQ-LERKH---------HTYI-----------------
-------L----------------------------------ISKLKSFEEE--------
EEEDLGGDGPRLGLL-------MMILGLIYLKGNS------VREA---QVWEMLRRL---
-----GAR-PSK----YHFLFGYPKRLIKEDFVQQ------RSLNYRRV--HTSPPEYEF
----SWGSRSNLETS--KMKVLGFVAKLH-------------------------------
------------------------------------------------------------
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---------------------------------------MDRRNDYGYRVPPFQ--G---
--------PLPPP--GSLGLP----------------------------FPPDIQTETTE
EDSV-LLMHTLL-------AATK--DSLAVDPPVVNRPKK-------------SKTKKAP
IKAI----------TKA-APA--APPVPTANEIATNKPKITLQALNLPVITQISQASPT-
T------------------------------------------------EVTN-------
------TQVSSVTVQPKKANKMKRVTAKAVQG-SQSPTGREGGATQLKSPLQVLNLPVIS
QNIHA---SIANESASSQTL-ITSVKPKKAS---------------KAK-----------
-------------KAA----------------NKAIASATEVSLAPTATHTA-TTQGQIT
-NETASIHTTAASIRTKKASKARKTIA--KVINTDTE-------HIQAANV---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------TETAT
RQIEA--------------------S---------------------------------V
IAIRPKKSKGKKAASRGP---------N------------SVSEISEALLATQMVTNQAL
AATLRVKRGS----RARKA----STKARATESQT----PNADQGAQAKMASAQ-TNVSAL
ETQ------------VA------------AAVQALADDYLAQL----SLEPTTRTRGKRN
RKM--------------------------------------------MKSKHLNGDERS-
GNNYRRIPWGRRPAP-PRDVAIL---QERANKLVK------YLLVKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LRDVIQEYDEYFPEIIERASYALEKMFRVNLKEIDKQSSLYI-LISTRES
SAG-IL-GTTKDS-PKLG---LLM----------VLLSI----------IF--------M
-NGNR----S-S--EAVIWEVLRKLGLR--PGVRHSLFGEVRKLITDEFVKQK-------
---------YLEYKRVPNSRP---P--EYEFFWGLRSYHETSKMKVLKFACKVQKK---D
------PKDWAVQYREAVEMEVQAAAVAVA--EAEAR----AEARAQMGIGEEAV-----
------AGP--WNWDDMDIDCLT-REELGDDAQAWS-RFSF----EIEARAQENADASTS
VNFSRGAGTRAGFSDGASISFNGAPSS--S----G-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------GPGITFGGAPSSSASFSNTASISFGGTLSTSS----------------
--------------------SFS------------------S----------------AA
SISFGGAPSTSTSFSSEASISFGGTPCTSASFSGGVSSSFSGPLN--TSATFSGAASSGF
GG------------------TL-STTAGFSSVLSTSTSFGSAPTTNTVFSSALSTSTGFG
GTLSTSVCFGGSPSSSGSFGGTLSTSICFGGSPCTSTGFGG----TLSTSVSFGGPSSTS
ANCGGTLSTSICFDGSPSTG-AGFGGALNTSASFGSVLNTS-------------------
-------------------------------------------------AGFGGAMSTSA
DFGSTLSTSVCFGGSPGTSVSFGGALNTSAGFGGAVSTSTDFGG----------------
------------------------------------------------------------
-----TLSTSVC------------------------------------------------
----------------------FGGSPSTSAGFSGALNTNASFGCAISTSAGFSGAVGTS
AGFSGVPSTNPGFGGAFNTSAGFGGALSTTTDFGGTPNNSIGFGAAPSTSVSFGGAHSTS
LCFGGAPSTSLCFGSASNTNLCFGGPPSTSACFSGATSPSFGDGPSTSTGFSFGNGLSTS
AGFGGGLNTSAGFGGGLGTSAGFSGD------------------------------LSTS
SGFDGGLGTSAGFSGGPGTSTGFGGGLGTSAGFSGGLGTGAGFGGGLVTSDGFGGGLGTN
ASFGSTLGTGAGFSSGLSTSDGFGSRPNASFDRGLSTIIGFGSGSNTSTGFIGEPRTSTG
FNSGPSSIVGFSGGPSTGVGFCSGPSI-SGFSGGPSTGAGFG------------------
------------------------------------------------------------
-------GGPNTGAGFGGG-PSTSAGFGSGATSLGACGFSYG

------------------------------------------------------------
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-----------------KRR-RYMFE-Q----------------DLQP----QGG-TQG-
-------------PEGGQFLVAEE------------------------------------
-----------------------------------------------------------E
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-SPQASCS---PSAAVA-A--SLSSNSAE----------------G-SSS-P-GE-----
----------------GPSTSQAQP------------DAEALLREAIDDKVADLV-----
-------QFLLLKYQTKELTT-KAEML--TTVIKEYQ-----DHFPVIFREASEC-----
----MQLVFGID---------MKE-VDPTS---------HSYV-----------------
-------L----------------------------------VNTLGL-TYD----GMLS
---G-DQGVPKTGIL-------ILILSIIFLEGNC------APEE---KIWEALSVM---
-----GVY-VGR----EHFIYGEPQKLITDDWVQE------KYLEYRQV-PDSSPARYEF
----LWGPRAHAETS--KMKVLEFLAKVNGSDPR----S-FPFWYEE---ALRDAEERAQ
ASVAATDATTA-------------------------------------------------
------------------------------------------------------------
-----------------------MA--------S----------------ESA----EA-
------------------------------------------------------------
---------MSG---------------------SFSC-----------------------
------------------PK----------------------------------------
------------------------------------------------------------
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------------------------------------------

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--------------------------------------MSSEQ-----------------
-----------------KSQ-HCKPE-E----------------GVEA----QEE-ALG-
-------------LVGAQAPTTEE------------------------------------
-----------------------------------------------------------Q
E-A---------------------------------------------------------
------------------------------------------------------------
---AVSSSSPLV----PGT--LEE------------------------------------
---------VP--------------------------------------AAGS---TGPP
QSPQGASA---LPTTVS-F--TCWRQPNE----------------GSSG--QEEEGP---
------------S------TSPDA---------------ESLFREALSKKVDELV-----
-------RFLLLKYRAKELVT-KAEML--ERVIKNYK-----RCFPVIFGKASES-----
----LKMIFGID---------VKE-VDPTS---------NTYT-----------------
-------L----------------------------------VTCLGL-SYD----GLLG
---NN-QIFPKTGLL-------IIVLGTIAMEGDS------ASEE---EIWEELSVM---
-----EVY-DGR----EHSVFGEPRKLLTQDWVQE------NYLEYRQV-PGSDPACYEF
----LWGPRALAETS--YVKVLEHVVRVNARVRI----S-YPSLREA---ALLEEGEGV-
------------------------------------------------------------
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-----------------------------------------------------MSEQSKD
LSD---------------------------------------------------------
------------------------------------------------------------
--------PNF----------------------------A---------------AEA-P
SSEV--------------------------HSS-----------------PGVPEG---V
P--PS-----ET---------LAEPQSPPLGP------------T---------------
----AAPQAA--------------------------------------------------
------QPP--------------QAPSDEDD---------PKAL-QQA-A-EE--GR---
----------------------AHQAP----SAAQPG-PAPPAPAQLVQKAHELM-----
-------WYVLVKDQKKMIIW-FPDMV--KDVIGSYK-----KWCRSILRRTSLI-----
----LARVFGLH---------LRL-TSLHT---------MEFA-----------------
-------L----------------------------------VKALEPEELD-----RVA
----LSNRMPMTGLL-------LMILSLIYVKGRG------ARES---AVWNVLRIL---
-----GLR-PWK----KHSTFGDVRKLITEEFVQQ------NYLKYQRV-PYVEPPEYEF
----FWGSRASREIT--KLQIMEFLARVFKKDPQ----A-WPSRYRE---ALEEARALRE
ANPAA----------------------------------HCPRSSVSED-----------
------------------------------------------------------------
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------------------------------------------

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--------------------------------------MSHRQ-----------------
-----------------QHE-QG-LK-E----------------GQV-------------
---------------W--------------------------------------------
---------------------------------------------------EMDP-----
--V---------------------------------------------------------
---------------------------------------------------------AKH
VGNPEE------------------RP----------------------------------
---------AA--------------------------------------VV---------
-SQKAS------------------SSAAP----------------IQPTL-PEGD-E---
------------S------TSKAYL------------YSKFLLNSQIRKKTTDLV-----
-------KFLSFKYTRNEPVT-EADIL--KNVVQEYK-----DYYSLIFKHACEC-----
----MEVVFGIE---------IKE-VDAFN---------HSYE-----------------
-------L----------------------------------LKILDL-TYD----GRLS
---ED-EGIPRTGLL-------ALILGVIFMEGNR------APEK---KIWEVLNMV---
-----GVY-PDQ----HDFICGNPRKFITEDLVLE------KYLECKLV-SRSYPPTYEF
----LWGPRAHAETS--KMKVLQFFSKVAGSNPT----S-FTALYKE---ALKDEEERAR
AILASTSIASP-------------------------------------------------
------------------------------------------------------------
-----------------------SA------PDN----------------SGS--G--E-
------------------------------------------------------------
---------KPS---------------------SFSH-----------------------
------------------PK----------------------------------------
------------------------------------------------------------
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------------------------------------------

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------------------------------------------------------------
--------------------------------------MPLER-----------------
-----------------RGQ-YCKPE-E----------------GLEA----QGE-SLG-
-------------LVGAQAPATEE------------------------------------
-----------------------------------------------------------Q
E-T---------------------------------------------------------
------------------------------------------------------------
----ATSSSTLV----EVT--LGE------------------------------------
---------VP--------------------------------------AAES---SSPP
HSPQGAST---LPTTIN-Y--TLWSQSDE----------------GSSN--QEQEGP---
------------S------TFPDL---------------ETSFQVALSRKMAELV-----
-------HFLLLKYRAREPFT-KAEML--ESVIRNCQ-----DFFPVIFSKAAEY-----
----LQLVFGIE---------VVE-VVPIG---------RLYI-----------------
-------I----------------------------------VTCLGL-SYD----GLLG
---DN-EIMPKTGLL-------IIVLAIIAIEGDC------APEE---KIWEELRVL---
-----EAS-DGR----EDSVFAHPRKLLTQDLVQE------NYLEYRQV-PGSDPACYEF
----LWGARALIETS--CVKVLHHMLKISGGPHI----S-YPPLHEW---ALREGEE---
------------------------------------------------------------
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------------------------------------------

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------------------------------------------------------------
--------------------------------------MPLEQ-----------------
-----------------RSQ-HCKPE-E----------------GLEA----RGE-ALG-
-------------LVGAQAPATEE------------------------------------
-----------------------------------------------------------Q
Q-T---------------------------------------------------------
------------------------------------------------------------
----ASSSSTLV----EVT--LGE------------------------------------
---------VP--------------------------------------AAES---PSPP
HSPQGASS---FSTTIN-Y--TLWSRSDE----------------GSSN--QEEEGP---
------------R------MFPDL---------------ESEFQAAVSRKMAELV-----
-------HFLLLKYRAREPFT-KAEML--ESVIRNCQ-----DFFPVIFSKASEY-----
----LQLVFGIE---------VVE-VVPIG---------RLYI-----------------
-------V----------------------------------VTCLGL-SYD----GLLG
---DN-EIMPKTGLL-------IIVLAIIAIEGDC------APEE---KIWEELSVL---
-----EVF-EGR----EDSVFAHPRKLLIQDLVQE------NYLEYRQV-PGSDPACYEF
----LWGPRALVETS--YVKVLHHIVKIDGEPHI----S-YPPLHEW---ALREGEE---
------------------------------------------------------------
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------------------------------------------

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------------------------------------------------------------
------------------------------------------------------------
--------------------------------------MPLEQ-----------------
-----------------RSQ-HCKPE-E----------------GLEA----RGE-ARG-
-------------LVGAQAPATEE------------------------------------
-----------------------------------------------------------Q
Q-I---------------------------------------------------------
------------------------------------------------------------
----ASSSSTLV----EVT--LGE------------------------------------
---------VP--------------------------------------AADS---PSPP
HSPQGASS---FSTTIN-Y--TLWRQSDE----------------GSSN--QEEEGP---
------------R------MFPDL---------------ESEFQAAISRKMVELV-----
-------HFLLLKYRAREPVT-KAEML--ESVIRNFQ-----DFFPVIFSKASEY-----
----LQLVFGIE---------VVE-VVPIS---------HLYI-----------------
-------L----------------------------------VTCLGL-SYD----GLLG
---DN-QIMPKTGLL-------IIVLAIIAIEGDC------APEE---KIWEELSML---
-----EVF-EVG----EDSVFEHPRKLLMQDLVQE------NYLEYRQV-PGSDPACYEF
----LWGPRALIETS--YVKVLHHTLKMGGEPHI----S-YPPLHEW---ALREGEE---
------------------------------------------------------------
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--------------------------------------MPRRHK---NKFHTSGKR-HQV
-WG-----DTQEA-----------------------------------------------
-QA-------------SAAATPKE------------------------------------
-----------------------------------------------------------E
-CP--------------------------SSPTS-----A---------------PQGSP
LSSP-A-------------------------AGD----------------HQELEG---A
M--APSSPDA-G------------------------------------------------
------------------------------------------------------------
-----------------PS----CAGSDEGA---------------QG-P-EE-ESA---
-----------------------------GA-SQAAPATQSTRKDPLARKARILV-----
-------EFLLEKYTKKEPIT-QKALM--KIVSRKYR-----QHFPEILSTACER-----
----VELVFGLE---------MKE-VDHSR---------NIYT-----------------
-------L----------------------------------ISKLNL-EGN---DCP-S
----GEGALPKSGLL-------MVLLGVIFMNGNH------ATEE---EIWEFLSML---
-----GIY-AGR----RHWIFGEPRRLITKDLVQK------EYLNYCQV-PNSDPPRYEF
----LWGPRACAETS--KMKVLEVLAKFHGRVPS----S-FPVLYDE---ALRDQVERAG
LR-DAARAPPM-AE----------------------------------------------
----------------------------------------------------------AS
--------------------APS--R-----------------------AKSR-SSSHI-
------------------------------------------------------------
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-------------MEFQEVQQ-AQ-AL--AWQAPKAP-----GQFWQPVPTQEAQRQ---
----GPPLVQME-------QPFQGVPASQKALQIQL-PTQQAQPS--GPQAELPTLQLQP
SWQGPPTALQGQPGAPIAAANFPMGSAKSLMTP-SGESRASSIERRTSS-KE----RRTS
SK--ERRAPSKDRM----------IFAATFCAPKA----VSAARAHLPTAWKNLPATSEN
FTATSRVF-PTT----SRFQPASSNAFQGPSAPSE----TPKSLPLAL---QDPYACVEA
LPAVPWVPQPNVNASKASQAVPTILM-ATAAAPK----A-MATI-QE---ASKTSAEPPR
RS-----------------------GKA--------------------------------
--TRK-----KKHLNTEE-DSSGQMLA-------------------------------LR
--D-WQAP----RPWENLN--LNDW--EIENPIQ-V--LGDWEGPSTSRGLSGWEGPSTS
-RI---------------LSG---WEGPSTTWALSAWEGPSTSR-A--------------
---------LGLW---------------ESPGSPQPLIISEFT-------------S---
LSQGFGATQNDPRLE-TQPLSPL---DERANALVQ------FLLVKD-QAKVPI--KR--
------------------------------------------------------------
----SEM---VKFIIREYKDECLDIINRANNKLECVFGYQLKEIDPENHSYI-IINKLGH
HKGEPV-ASYLDR-PKLG---LLM----------VVLSL----------IF--------M
-KGNC----V-R--ENMIFNFLYRLGLD--VRETHALFGNTKKLITEVFVRQK-------
---------YLEYRRIPYTEP---A--EYEFLWGPRAFLETSKMLVLRFLAKLHKR---D
------PRCWPFQYFEALAECESEDLDEDE-PGS----GDNA-------GDP--------
---TSSSPPR--------------------------------------------------
------------------------------------------------------------
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---------------------------------------MAQKPDGGAGLRGFQA-----
--------------------------------------------------------EASV
EDSA-LLVQTLM-------EAIQ--IS-EAPPTSQA--TA--------------------
------------------------------------------AASGPNASPQSSQPPTA-
N------------------------------------------------EKAD-------
------TEVSAAAARPKT------------------------------------------
-----------------------------GF---------------KAQ-----------
-------------NAT----------------TKGPN---DYSQARNAKEMP-KNQSKAA
F-------------------KSQNGTP--KGPHAASD-------FSQAAPT---------
----GKS-AKKSEMAFKGQNS--TKAGPGT---------T-YNFPQSPSANEMTNNQPKT
------------------------------------------------------------
----------------------------------------------A-KAWNDTTKVPGA
-------------------------------DAQT-----------QNV-----------
----NQA---KMADVG--------T------SAG---------ISEADGAAAQTSADGSQ
TQNVE--------------------S---------------------------------R
TIIRGKRTRKVNNLNV---------EENNSGDQRRASLASGNWRSAPVPVTTQQNPPGAP
PNVVWQTPLA----WQNPS----GWQNQTARQTP----PAARQSPPARQTPSAWQNPVAW
QNPVIWPNPVIWQNPVIWPNPI-VWPGPIVWPNPMAWQSTPGWQSPPSWQAPPSWQSPQD
WQG---PPDWQVPPDW-SMPP-DWSFP-SDWPFPPDWIPADWPIPPDWQNLRPSPNLRS-
-SSNSRASQNQGPPQ-PRDVALL---QERANKLVK------YLMLKD-YTKVPI--KR--
------------------------------------------------------------
----SEM---LRDIIREYTDVYPEIIERACFVLEKKFGIQLKEIDKEEHLYI-LISTPE-
SLAGIL-GTTKDT-PKLG---LLL----------VILGI----------IF--------M
-NGNR----A-T--EAVLWEALRKMGLR--PGVRHPLLGDLRKLLTYEFVKQK-------
---------YLDYRRVPNSNP---P--EYEFLWGLRSYHETSKMKVLRFIAEVQKR---D
------PRDWTAQFMEAADEALDALDAAAA--EAEAR----AEARNRMGIGDEAV-----
------SGP--WSWDDIEFELLT-WDEEGDFGDPWS-RIPF----TFWARYHQNARSRFP
QAFTG---------------------P--IIGPSGTATA------NFAANFGAIGF----
--------FWVE------------------------------------------------
------------------------------------------------------------
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------------------------------MPR---------------------------
----------------------GQKNK-------------------------------HH
RNRLKNKKHNQEKVHPQKDESQEKGH-HKRDDFQD---HKEAR-DNAAVEEKS-SCSSP-
-SV-------------------PGE-TLE-KPPASKTSS------D------------AG
---------WLSC---V-------------SSPATVC-GDELE---------FDDGTYFH
CGGNSLYSEYRTCQE-NPCKHCL---DMYVNLVEQ------YVLYKF-KMKKLI--DR--
------------------------------------------------------------
----NEL---IDLIEPKYRYNFSDIFKRAFENIEIVFAASVIEIDSTNHVYD-LVSKLKL
PNKGRV-CPGRGL-PKTG---LLM----------TILAM----------IF--------M
-NGNS----A-S--EEDIWKFLNYMQVY--PGRKHFIYREPRKLITQDFVKLK-------
---------YLEYKQISLSDP---P--CYRFQWGPKAYTETTKMKVLEFMAKGSGV---E
------PSTFSVQYTEALREENQKTKIRKW-YP---------ILA----QKHCPGHSH--
QHVQKVMKPQ--------------------------------------------------
------------------------------------------------------------
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--------------------------------------MSLG-H----------------
-----------------MSE-HCKPE-E----------------DPHA----PTE-AQG-
-------------LEGVQDPMVEK------------------------------------
-----------------------------------------------------------G
E-AT-----------------------ATTT----------PSL----------------
-----------------------------------------------------------T
SPSAPSPITPLI----LGT--PEEV---P---------------------ATG-------
----------A--------------------------------------LGPL-------
PSSKIVCF---SPTAAP-A--MPRSQSAE----------------S-SRR-EEEEGA---
------------CI------SQDPA------------DPESLLREELNKKMAELV-----
-------QFLTVKYVTKEPIT-EAEML--TNVIKEHK-----DHFPLIFSKVSEC-----
----MEIVFGIE---------VKE-VDPSS---------HSYV-----------------
-------L----------------------------------VRTLDL-TYD----GMLR
---DDDQSMPKTGLL-------IFILGVIFMEGNR------ASEE---KVWEVLSMM---
-----GVY-AGR----EDFIYGEPRKLITEDLVKE------QYLVYQEV-PDSDPPRYEF
----LWGPRAYAETS--KMKVLKFFAKISGTDPT----S-LPFWYEE---ALQDEKERGQ
AGAAAGDGATS-------------------------------------------------
------------------------------------------------------------
-----------------------TA--------S----------------GSS----SV-
------------------------------------------------------------
---------TSA---------------------ASPA-----------------------
------------------LSEA--------------------------------------
------------------------------------------------------------
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------------------------------MPR---------------------------
----------------------AHKRK-------------------------------GR
--------------------APKKSR-HTGQDAQA---HR-AAQGGTELAEEP-SSSSS-
---------------------VLEDIPRS-SSAAVSGTPPPRPS-S-------------P
---------P-ST---S------------TTSGRVPDTRPHEG------D-----DSQGE
EEQ QPPSSGVTPSAD-RSHSDAL---ATKVDLLEQ------FLLYKY-KMKQPI--MK--
------------------------------------------------------------
----ADM---LMVVNTKCPHLFAEILQGASRSIEALFAVEVKEINSTCQSYD-LVSKLKL
PNNGRV-RPGRGL-PKTG---LLM----------TLLGV----------IF--------M
-KGNR----A-T--EEDVWKFLNTMRIY--AGRKHFIYGEPRKLITKDLVRLQ-------
---------YLEYRRLPDTDP---A--RYEFLWGPKAHAETSKMKVLEFVAKARDT---V
------PTAFPSQYEEALRDQEERARVGTA-ATPGATARA------RLRSCTCPAASSLL
LKSKDICYPE-ENLSHHDRSCL--------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
-------------------------------------MMPHGQ-----------------
-----------------RSQ-DSNLE-G----------------DYST----QSG-AQV-
-------------FVDVQGLEETV------------------------------------
-----------------------------------------------------------E
EETAATAS----------------------------------------------------
--SASC------------------------------------------------------
------PSYNVI----RTT--PRE------------------------------------
---------AP--------------------------------------GLGT---LSCL
QNSQGISC---PPSATV-S--SQKNQCSE----------------GSSRQ-EKRGSR---
------------P------LWD-------------MDVPRFLRNVLLNDKLRKLV-----
-------SFLLCKYQKKEQTT-LEEML--HVVDDDYR-----EHLLLTFRELCES-----
----ICLGFGIE---------VKE-VDPPG---------HTYV-----------------
-------L----------------------------------VPVLGL-TYN----GILD
-D-DD-QIIAKFDLL-------IYTLTAVFMRGNQ------VSEK---VLKKQVIKW---
-----GML-ALR----EHIVIGEPWKFITEDLVRE------EYLVYQRV-PNSDPARYEF
----LWGPRAHAETT--QMKLLEHVAQLNRADPR----S-YPQLYNQ---ALREENGMFR
AHEGQNV-----------------------------------------------------
------------------------------------------------------------
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---------------------------------------MDRRNDYGYRVPPFQ--G---
--------PLPPP--GSLGLP----------------------------FPPDIQTETTE
EDSV-LLMHTLL-------AATK--DSLAMDPPVVNRPKK-------------SKTKKAP
IKAI----------TKA-APA--APPVPTASEIATNKPKITLQALNLPVITQISQASPT-
T------------------------------------------------EVTN-------
------TQVSSVTVQPKKANKMKRVTAKAAQG-SQSPTGREGGATQLKSPLEVLNLPVIS
QNIHA---PIANESASSQTL-ITSIKPKKAS---------------KAK-----------
-------------KAA----------------NKAIASATEVSLAPTATHTA-TTQGQIT
-NETASIHTTAACIRTKKASKARKTIA--KVINTDTE-------HIEAANV---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------TETAT
RQIEA--------------------S---------------------------------V
VAIRPKKSKGKKAASRGP---------N------------SVSEISEALLATQMVTNQAL
AATLRVKRGS----RAWKA----STKARATESQT----PNPDQGTQAKMASAQ-TNVSAL
ETQ------------VA------------AAVQALADDYLAQL----SLEPTTRTRGKRN
RK-----------------------------------------------SKHLNGDERS-
GNNYRRIPWGRRPAP-PRDVAIL---QERANKLVK------YLLVKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LRDVIQEYDEYFPEIIERASYALEKMFRVNLKEIDKQSSLYI-LISTRES
SAG-IL-GTTKDT-PKLG---LLM----------VILSV----------IF--------M
-NGNK----A-S--EAVIWEVLRKLGLH--PGVRHSLFGEVRKLITDEFVKQK-------
---------YLEYKRVPNSRP---P--EYEFFWGLRSYHETSKMKVLKFACKVQKK---D
------PKDWAVQYREAVEMEVQAAAVAVA--EAEAR----AEARAQMGIGEEAV-----
------AGP--WNWDDMDIDCLT-REEFGDDAQAWS-RFSF----EIEARAQENADASTN
INFSRGAGTRAGFSDGASISFNGAPSS--S----G-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------GPGITFGGAPSSSASFGNTASISFGGTLSTSS----------------
--------------------SFS------------------S----------------AA
RISFGGAPSTSTSFSSEASISFGGTPCTSASFSGGVSSSFSGPLN--S-ATFSGAASSGF
GG------------------TL-STTAGFSGVLSTSTSFGSAPTTNTVFSSALSTSTGFG
GTLSTSVCFGGSPSSSGSFGGTLSTSICFGGSPCTSTGFGG----TLSTSVSFGGSSSTS
ANCGGTLSTSICFDGSPSTG-AGFGGALNTSASFGGALNTS-------------------
-------------------------------------------------AGFGGAMSTST
NFGGTLSTSVCFGGSPGTSVSFGGALNTSAGFGGAVSTSTDFGG----------------
------------------------------------------------------------
-----TLSTSVC------------------------------------------------
----------------------FGGSPSTSAGFGGALNTNASFGCAISTSAGFSGAVGTS
AGFSGVPNTNPGFGGAFNTNAGFGGALSTTTEFGGTPSNSIGFGAAPSTSVSFGGAHSTS
LCFGGAPSTSLCFGSASNTNLCFGGPPSTSACFSGATSPSFGDGPSTSTGFSFGNGLSTS
AGFGGGLNTSAGFGGGLGTSAGFSGG------------------------------LSTS
SGFDGGLGTSAGFSGGPGTSTGFGGGLGTSAGFSGGLGTGAGFGGGLVTSDGFGGGLGTN
ASFSSTLGTGAGFSGGLSTSDGFGSRPNASFDRGLSTIIGFGSGSNTSTGFTGEPSTSTG
FNSGPSSIVGFSDGPSTGVGFCSGPSI-SGFSGGPSTGAGFG------------------
------------------------------------------------------------
-------GGPNTGAGFGGG-LSTSAGFSSGATSLGACGFSYG

------------------------------------------------------------
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-------------------------------------------M----------------
-------------HEDQRSQ-LYRPE-G----------------QPQA----QGE-APG-
-------------RLWTVIPIAGK------------------------------------
-----------------------------------------------------------H
E--S----------------------------T---------------------------
------------------------------------------------------------
---NSSFSS---------------------------------------------------
-------------------------------------------------PVSG---TQRE
VSAAGILS----PP----Q--FSKSLL------------------S-DCS-EFHDGT---
------------G------ACQDPT------------AHESSHLGTLEVKMGELL-----
-------QLLLHKYRMKEPIT-KVEML--SCVGKNYE-----DQFPAIFSKVCGC-----
----MQLALGID---------VKE-VDPVG---------HSYE-----------------
-------L----------------------------------NTALGL-TYD----GMLD
---DD-QSMPKTSLL-------IMILGLIFSEGNC------AFEK---ELWESLSVM---
-----GVY-ADR----EHHIYGEPRKLLTEEWVRE------GYLEYLQV-SHSDLACCVF
----LWGPRAHAETT--KMRVLEYLAKFSNTDAR----S-FASLYEE---ALRDEQARVQ
AGDAVGAGGGA-------------------------------------------------
------------------------------------------------------------
-----------------------RA-----------------------------------
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--------------------------------------MPRGQK---SKLRAREKR-RKA
-RD-----ETQRL-----------------------------------------------
-NV-------------PQVTEAEE------------------------------------
-----------------------------------------------------------E
-EAP-------------------------CCSSS-----V---------------SGGAA
SSSP-A-------------------------AGI----------------PQKPQR---A
P---TTAAAAAA------------------------------------------------
------------------------------------------------------------
----------------GVS----STKSKKGA---------------KSHQ-GE-KNA---
-----------------------------SS-SQASTSTKSPSEDPLTRKSGSLV-----
-------QFLLYKYKIKESVT-KGEML--KIVGKRFR-----EHFPEILKKASEG-----
----LSVAFGLE---------LNK-VNPNG---------HTYT-----------------
-------F----------------------------------IDKVNL-TDE---ESL-L
----SSWDFPRRKLL-------MPLLSVIFLNGNS------ATEE---EIWEFLNML---
-----GVY-DGE----EHSIFGEPRKLITKDLVRE------KYLEYKQV-PSSDPPRFEF
----LWGPRAYAETS--KMKVLEFLAKVNGTTPC----A-FPTRYEE---ALKDEEKAGV
------------------------------------------------------------
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---------------------------------------MSDT-----------------
---------------SE-SGA----------------------------GVTRFQTEASE
KDSS-LTMQTQL-------TVTQ--NAEAPETSKAS------------------KA----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------PEVSEDVKVS-------KASGVS---------------KAT-----------
-------------EV---------------------------SKTPEAQEAP-ATQASST
-TQLTDTPVLAA----EN--KSPAADT--KKQNADPQ-------AVTMPAT---------
----ETKK-----ASC--------------------------------------------
------------------------------------------------------------
--------------------------------------------------------VA--
-------------------------------DTKV-------------------------
----N-A--KAQETEA--------AASQAPADEP---------E--PESTAVQAQENQDT
RPKVK--------------------A---------------------------------K
KARKVKHLDGEEDGS---------------SDQSQTSGTTGGRRVSKALMASMARRASRG
PIAFWARRAS----RTRLA----A------------------------------------
------------------------------------WARRALL----SLRSPKARRGKAR
RRA---------------------------------------------------------
-AKLQS-SQEPEAPP-PRDVALL---QGRANDLVK------YLLAKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LKDIIKEYTDVYPEIIERAGYSLEKVFGIQLKEIDKNDHLYI-LLSTLEP
TDAGIL-GTTKDS--KLG---LLM----------VLLSI----------IF--------M
-NGNR----S-S--EAVIWEVLRKLGLR--PGIHHSLFGDVKKLITDEFVKQK-------
---------YLDYARVPNSNP---P--EYEFYWGLRSYYETSKMKVLKFACKVQKK---D
------PKEWAAQYREAMEADLKAAAEAAA--EAKAR----AEIRARMGIGLGAE-----
----NAAGP--CNWD-------------DADIGPWA-KARIQAGAEAKAKGQESG--SAS
TGTSTST------NNSA------SAST--SGGFSAGTSLTATLTFGLFAGLGGAGASTSG
SSGACG-FSYK-------------------------------------------------
------------------------------------------------------------
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--------------------------------------MLLRQ-----------------
-----------------KRQ-SCKAE-E----------------GRQA----QGD-APG-
-------------LMDVQILTTEE------------------------------------
-----------------------------------------------------------Q
K-A---------------------------------------------------------
------------------------------------------------------------
----ASSSSTLI----AGT--LEE------------------------------------
---------VP--------------------------------------DSGS---LSPA
QSPRGASS---SLTVTD-D--TLWSQSNE----------------VSSS--NEEEGP---
------------S------TSPDPA------------HLESLFREALDEKVAELV-----
-------HFLLRKYQIKEPVT-KAEML--ESVIKNYK-----NHFPEIFSKASEC-----
----MQVIFGID---------VKE-VDPAG---------HCYV-----------------
-------L----------------------------------VTCLGL-SYD----GLLG
---DD-QSTPKTGLL-------IIVLGMILMKGSC------APEE---AIWEALSVM---
-----GLY-DGR----EHSVYWKLRKLLTQDWVQE------NYLEYRQV-PGSDPVRYEF
----LWGPRALAETS--YVKVLEHVVRVNARVRI----S-YPSLHEE---ALGEEKEGV-
------------------------------------------------------------
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----MSQ-----------------RKRSRGS---------------GLTQ-G--------
----------------DDEDFSVVPTQ--SP-SQVQRNLESRSQEEINRKVTELV-----
-------QFLLVKDQKKIPIK-RVDIL--KKVIREYK-----DVYSEIVNRAGRT-----
----LQQVFGLQ---------MVE-IDTKH---------HIYI-----------------
-------L----------------------------------TSTLPRVEGE-----NLK
----QDIQTAKLGLL-------IVILSFIFMKGNS------AKDS---AVWEFLRRL---
-----RVH-PGE----KHEVFGDVKKLVMEEFVRQ------KYLEITPI-PLTDPPEFNF
----QWGPRAAKETS--KKDILSFVAKMQKKEPS----F-WISQYNE---AKANT-----
------------------------------------------------------------
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--------------------------------------MPRGQK---SKLRAREKR-HQA
-RC-----ENQDL-----------------------------------------------
-GA-------------TQAPVAE-------------------------------------
------------------------------------------------------------
GESS-------------------------SSANL-----L---------------FGDRP
QNLP-A------------------------AETLS-------I-------PEALQG---A
P--STTNTIA-P------------------------------------------------
------------------------------------------------------------
-----------------VS----CTSSNEGA---------------SN-Q-DE-KSL---
------------------------------G-S--SREAEGWQEDPLSKKVVSLV-----
-------HFLLQKYEKKEPIT-KGDMI--KFVIRKDK-----GHFNEILKRASEH-----
----IELAFGVD---------LKE-VDPIR---------HYYA-----------------
-------F----------------------------------FSKLDL-TYD----ETTS
----DEEKIPKTGLL-------MIALGVIFMNGNR------APEE---AVWEIMNVM---
-----GVY-ADR----KHFLYGDPRKVMTKDLVQL------KYLEYQQV-PDSDPPRYEF
----LWGPRAHAETS--KMKVLEFVAKMHDTVPS----A-FPSCYEE---ALRDEEQRAQ
AR-VAARAHTA-AM----------------------------------------------
----------------------------------------------------------AN
--------------------ARS--R-----------------------TTSS-SFSHAK
------------------------------------------------------------
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--------------------------------------MLHS-P----------------
-----------------KSQ-SGKLE-A----------------GLQV----QKE-AQG-
-------------LVGAQVPVAEE------------------------------------
-----------------------------------------------------------E
A-----------------------------------------------------------
------------------------------------------------------------
---ASSSLAPFI----QGT--PEVV---P---------------------AAG-------
----------T--------------------------------------PSVP-------
QSAERA---------LE-A--IPSSKSNE----------------G-FST-Q-EEDP---
------------SIF---------R------------SPEFLLGSVLNKKVVELV-----
-------QFLSVKYVTKEPIT-EAEML--RNVIKEQK-----NHFPLIFSKVCEC-----
----MEVVFGIE---------VKE-VDPTN---------HTYV-----------------
-------L----------------------------------IKTLDL-TYD----GMLS
---D-DQGMPKTGLL-------ILVLGVIFMEGNR------APEE---KVWEVLNSI---
-----GVY-AGQ----KDFIYGEPVKLITKDLVKE------KYLEYQQV-PNSDPPRYEF
----LWGPRAHAETS--KMKVLEFFAKVSGTDAT----S-FTSWYEE---ALRDEKERAQ
DKAAAGDNTAA-------------------------------------------------
------------------------------------------------------------
-----------------------MA--------S----------------GSS----GS-
------------------------------------------------------------
---------FES---------------------HM-------------------------
------------------------------------------------------------
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--------------------------------------------------MLQTPE---S
R--------------------------------------------------GLPVP----
-------QAE----------------------------GEKDGGHDGETRART-----A-
-SQQ-------------------RPKEELGA---------------GREE-G--------
----------------AAEPALTRKGA--RA-LAAKALARRRACRRLNRTVAELV-----
-------QFLLVKDKKKSPIT-RSEMV--KYVIGDLK-----ALFPDIIARAAEH-----
----LRYVFGFE---------LKQ-FDRKH---------HTYI-----------------
-------L----------------------------------INRLKPLEEE----E---
EEEDLGGDGPRLGLL-------MMILGLIYMRGNR------AREA---QVWEMLHRL---
-----GMQ-PSK----YHFLFGYPKRLIMEDFVQQ------RYLSYRRV-PHTSPPEYEF
----SWGPRSNLEIS--KMKVLGFVAKLHKKEPQ----H-WPVQYRE---ALADEADRAR
AKAR-AEASMRARA--------SARA------G---------------------------
------------------------------------------------------------
-IH----L------W---------------------------------------------
------------------------------------------------------------
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---------------------------------------MAQKMDCGAGLLGFQSPDA--
--CRAVCHPLPQPPASTLPLSAFPT-LCDPPYSQLRHPPAVLSCYCTPLGASPAPAEASV
EDSA-LLMQTLM-------EAIQ--IS-EAPPTNQA--TA--------------------
------------------------------------------A-----ASPQSSQPPTA-
N------------------------------------------------EMAD-------
------IQVSAAAARPKS------------------------------------------
-----------------------------AF---------------KVQ-----------
-------------NAT----------------TKGPNGVYDFSQAHNAKDVP-NTQPKAA
F-------------------KSQNATP--KGPNAAYD-------FSQAATT---------
----GELAANKSEMAFKAQNAT-TKVGPNA---------T-YNFSQSLNANDLANSRPKT
------------------------------------------------------------
----------------------------------------------PFKAWNDTTKAPTA
-------------------------------DTQT-----------QNV-----------
----NQA---KMATSQ--------ADIETD--PG---------ISEPDGATAQTSADGSQ
AQNLE--------------------S---------------------------------R
TIIRGKRTRKINNLNV---------EENSSGDQRRAPLAAGTWRSAPVPVTT-QNPPGAP
PNVLWQTPLA----WQNPS----GWQNQTARQTP----P-ARQSPPARQTPPAWQNPVAW
QNPVIWPNPVIWQNPVIWPNPI-VWPGPVVWPNPLAWQNPPGWQTPPGWQTPPGWQGPPD
WQG---PPDWPLPPDW-PLPP-DWPLP-TDWPLPPDWIPADWPIPPDWQNLRPSPNLRP-
-SPNSRASQNPGAAQ-PRDVALL---QERANKLVK------YLMLKD-YTKVPI--KR--
------------------------------------------------------------
----SEM---LRDIIREYTDVYPEIIERACFVLEKKFGIQLKEIDKEEHLYI-LISTPE-
SLAGIL-GTTKDT-PKLG---LLL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPLLGDLRKLLTYEFVKQK-------
---------YLDYRRVPNSNP---P--EYEFLWGLRSYHETSKMKVLRFIAEVQKR---D
------PRDWTAQFMEAADEALDALDAAAA--EAEAR----AEARTRMGIGDEAV-----
------SGP--WSWDDIEFELLT-WDEEGDFGDPWS-RIPF----TFWARYHQNARSRFP
QTFAG---------------------P--IIGPGGTASA------NFAANFGAIGF----
--------FWVE------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------

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------------------------------------------------------------
--------------------------------------MPPSP-----------------
-----------------KRP-RLSLE-A----------------DFQV----HND-IQ--
------------------------------------------------------------
-----------------------------------------------DLG----------
--TQT---N------EE---------------------EKE-------------------
---------------------------------------------------------DST
SSSLPS--SPVI----PNT--E-KK-----------------------------------
------GPV------------------------------------------------VAT
LNPQNSGR----------C--TSWGPSYG----------------GSSNP-QVKGAS---
-------------------SL-----------------------HILNEKVMELV-----
-------QLMILKYRLREPIT-RAEML--KVFLKGYR-----RRFPVIFKKASKC-----
----LEVIFGIE---------LKE-VDPTV---------HSYI-----------------
-------L----------------------------------VNSLGL-TYD----HM--
LS-NN-QSMPKIGLL-------IIILGLIFLEGNC------APEE---NIWDFLNMV---
-----GVG-VGR----DHFLCGDPWMLLTKEWVQE------NYLIYRQV-QNSNPLRYEF
----LWGPRALAETN--KMKVLEFLDKIKGTDPI----S-YSLWYEK---AVRDEEERAR
ARFVPTESTSP-------------------------------------------------
------------------------------------------------------------
-----------------------LS------TSQ----------------RNK--A----
------------------------------------------------------------
---------------------------------SCPS-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
---------------------M-------PLVSRNARP----------------------
------------------------------------------------------------
------------------GTAEAT------------------------------------
-----------------------------------------------------------A
-DY---------------------------------------------------------
-----------------------------------------------------------G
D--GRGEGQA----------------PCDSGS------------P-T-------------
---------------------------------------------------SM------L
----------AADAPQ----RPLAPVDPRGA---------------GAPQ-AA-------
---------QGA----N--DLEV--LID-EQSRRLGA---LRVHDPLEDKSIALV-----
-------NFMRMKNQAEGFIR--QTEM--LDFLREYS-----DQFPEILRRASAH-----
----LDQVFGLN---------LRV-LDPQA---------DTYN-----------------
----------------------L-------------------ISKRGL-QTA----DETA
----ESLDVPKAGLL-------ALVLGHILLNGNR------AREA---SIWDVLLKV---
-----NVL---DEPQRINSVFGNTKNVLIADLVHM------RFLEYWPV-YGTNPLEFEF
----LWGSRAHR--EITKT-----------------------------------------
------------------------------------------------------------
--------------------------E-------------------------------AL
K-----------------------F---VA----------------EAHDEEP-------
------------------------WSWPE-KYS------------KALEADKAKER---S
---------------------------------------------------------QA-
AG---L--------E-FWSED---TMTDKANDLVQ------LAINVT-EELLPI--HQ--
------------------------------------------------------------
----DEL---LARTGKEFEDVFPNILSRATLILDLFYGFSLIEVDTSEHIYL-LVQQPES
EEEQML-LESLGR-PTQD---YVM----------TILGL----------IF--------L
-MGNR----V-K--EANIWNLLCRFGMD--VGRKRAI--------TCKLMRQR-------
---------YLECRPLSYSNP---I--ECELLWGPRAHLETTKMKALEYMARIYRK---R
------PQDWPEQYREAVE-----------DEEARARSEATATFF----FGP--------
---M--------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------

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------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MSDT-----------------
---------------NK-SGS----------------------------GLTHFQAGAPE
EDGS-LVMQTLL-------AVTQ--NLEVSEAPKTV------------------NA----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------PEVLGGLKVS-------SIPGVS---------------KAS-----------
-------------EV---------------------------SKAQKAPEAF-ATQASPT
-TQQTDIQVLTA----EN--NSPATDI--KMQNADPQ-------AVPVHAT---------
----ETKK-----VGS--------------------------------------------
------------------------------------------------------------
--------------------------------------------------------VP--
-------------------------------DTQV-------------------------
----N-T--KALETEA--------SVSQIPTDEP---------GP--EGAAAETQENQDV
RPKVK--------------------A---------------------------------K
KALKXXXXXXXXXXXXXXXXXXXXXXX---------------XXXXXXXXXXXXXXXXXX
XXXXXXXXXX----XXXXX----X------------------------------------
------------------------------------XXXXXXX----XXXXXXTRRGKAH
RR----------------------------------------------------------
-AKLQS-FQNREAPL-SRDVDLM---QEKANDLVK------YLLAKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LKDIIKEYTDVYPEIIERAGYSLEKXXXXXXXXXXXXXXXXX-XXXXXXX
XXXXXX-XXXXXX---XX---XXX----------XXXXX----------XX--------X
-XXXX----X-X--XXXXXXXXXXXXXXXXXXIHHSLFGDVKKLITDEFVKQX-------
---------XXXXXXXXXXXX---X--XXXXXXXXXXXXXXXXXXXXXXXXXVQKK---D
------PKKRAAQYREAMEADLKAAAEAAT--EAKAR----AEIRAQMGIGLGSE-----
----NAAGS--CNWD-------------EADIGPWA-KARIQAGAEAKTKTQESG--GTS
------------------------AGA--SNGFSASASLTSTLTFNLFSGLSGAGTN--N
SSGACS-FSYK-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------

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------------------------------------------------------------
------------------------------------------------------------
--------------------------------------MPRGQK---SKLRAREKR-HQA
-RC-----ENQDL-----------------------------------------------
-GA-------------TQATVAE-------------------------------------
------------------------------------------------------------
GESS-------------------------SSAYL-----L---------------FGDRP
QNLP-A------------------------AETPS-------M-------PEVLQG---A
P--STTNAIA-P------------------------------------------------
------------------------------------------------------------
-----------------VS----CTSSNEGA---------------SS-Q-DE-KSL---
------------------------------G-S--SREAEGWKEDPLSKKVVSLV-----
-------RFLLQKYEKKEPIT-KGDMI--KFVIRKDK-----CHFNEILKRASEH-----
----IELAFGVD---------LKE-VDPIR---------HYYT-----------------
-------F----------------------------------FSKLDL-TYD----ETTS
----DEEKIPKTGLL-------MIALGVIFMNGNR------APEE---AVWEIMNMM---
-----GVY-ADR----KHFLYGDPRKVMTKDLVQL------KYLEYQQV-PNSDPPRYEF
----LWGPRAHAETS--KMKVLEFVAKMNDTVPS----A-FPSCYEE---ALRDEEQRTQ
AR-A------A-AM----------------------------------------------
----------------------------------------------------------AN
--------------------ARS--R-----------------------TTSS-SFSHAK
------------------------------------------------------------
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--------------------------------------MPRGHK---SKLRAQEKR-RQN
-RA-----EKQSD-----------------------------------------------
-KS-------------AQVAAEEE------------------------------------
-----------------------------------------------------------G
-EAA-------------------------CSSSS-----V---------------LGDAP
SSST-G-------------------------AGT----------------LQAPQS---A
P--AATSAAAGA--S---------------------------------------------
------------------------------------------------------------
---------ATTSGAAAAS----CEIPAVKA---------------KG-H-VRKSKS---
------------------------------S-SRASISTKNAGQDLINQKAIMLV-----
-------EYLLYQYKKNDLIK-KEDML--KIIHKWFR-----KDFPEILGRASER-----
----MDRFFGLQ---------VKE-VKPNS---------NSYT-----------------
-------L----------------------------------VDSEDE---------SLS
----SGFRFPTKGIL-------MPVLGVISLNGNS------ATEE---EIWKFLNMM---
-----SVY-DGK----SHFIFGEPRKLITQDLVQE------KYLVYQLV-PNSDPPRYEF
----LWGPRAHAETS--KMKVLEVLADLSDTLPT----A-YSPHYEE---ALQDEEERKQ
ARAQ-A------------------------------------------------------
------------------------------------------------------------
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--------------------------------------MPHSQK---SKGCSGD----KH
---------HQAPG-DT---------------------------------------KS--
IEG-------------DQATA-AE------------------------------------
-----------------------------------------------------------E
-DKP-------------------------SAPV---------------------------
------------------------------------------------------------
--------------------------------------------------PFSSSS-PNS
PE-------------------------------------------DG-PRVLE-----S-
-------LPCTVA----------AAEASCPK------------A-AEQSQ-DPR------
------------------GRCKCS--------CGRPKLCSGSPTDPIGWRFNILV-----
-------QLLLHKHKMKEPIS-KDM----MKIINKYQ-----QHYPEMLRKASLH-----
----MEMVFDLE---------MKE-VDS-S---------QTYF-----------------
-------L----------------------------------VSLLEITRED----RLL-
----NIRGFPKMGLL-------LPVLGLVYTNSYQ------VIEE---TMWGFLNAV---
-----GIF-DGR----SHFIFGEPRKLLTRELVQE------KNLEYRQV-PNSQPPSYES
----LWGPRAQVEA---KRTVLEFLEKLVKMDIK----E-FHDLYER---TWRDEERRVA
AGVA-ARAYFRAKT--------SKA-----------------------------------
------------------------------------------------------------
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---------------------M-------SLVSQNARR----------------------
------------------------------------------------------------
------------------GSAETA------------------------------------
-----------------------------------------------------------A
-DY---------------------------------------------------------
-----------------------------------------------------------S
D--CQGEMQA----------------SNASGA------------P-T-------------
---------------------------------------------------SM------L
----------VPQALQ----GSRTPISPQGA---------------SASQ-AA-------
---------QDP----N--DLEV--LIE-EQSQRLGA---LRVHDPLEDRSIALV-----
-------NFMRMKSQTEGSIQ--QAEM--LEFLREYS-----DQFPEILRRASAH-----
----LDQVFGLN---------LRV-LDPQA---------DIYN-----------------
----------------------L-------------------ISKRGF-QTT----DRIA
----ESLDVPKAGLL-------ALVLGHILLNGNR------AREA---SIWDLLLKV---
-----DLL---GDPQRINNLFGNTRNLLITDFVRM------RFLEYWPV-YGTNPLEFEF
----LWGSRAHR--EITKM-----------------------------------------
------------------------------------------------------------
--------------------------E-------------------------------AL
K-----------------------F---VA----------------EAHDEEP-------
------------------------WSWPE-EYN------------KALEADKAKER---R
---------------------------------------------------------QA-
AG---L--------E-FWSED---TMNDKANDLVQ------LAINVT-EELLPI--HQ--
------------------------------------------------------------
----DEL---LAHTGKEFEEVFPNILSRATLILDLFYGFSLIEVDTSEHIYL-LVQQPES
EEEQMM-LDSLGR-PPQE---YVM----------PILGL----------IF--------L
-MGNR----V-K--EANIWNMLRRFGVD--VGRKHAI--------TCKLMRQR-------
---------YLECRPLSYSNP---V--EYELLWGPRAHLETTKMKALEYMARLYRK---Q
------PQDWPEQYREAVE-----------DEEARARSEATAMFF----FGS--------
---M--------------------------------------------------------
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------------------------------------------

------------------------------------------------------------
------------------MSL--VSQNSRRRRRRVAK---ATA-----------------
----------H-NSSWGEMQAPNAPGLPADVPGSDVPQGPSDSQILQ-GLCAS-------
---EG-----------------PST------------SVLPT------------------
---------------SAEGPST---------FVPPTIS---EASSASGQPTI-SEG-PGT
SVLPTP---------------S-EG----LSTSGPPTIS---------------------
-----KGLCTSVTLAASEGRN------TSRPPTSSEEPST---SV-------PPTASEVP
-S----------------------TSLPPTPGEGTSTSVPPTA--------YEGPSTSVV
PTPDEGPSTS-------------------VLPTPGEGPGTS-------VP--LAATEGLS
TSVQATPDEGPS--------TS---VP-----PTATEG------------LST---PVPP
T------RDEGPSTSVPATPGEGPSTSVLPAAS---------------DGQSIS------
------------------------------------------------------------
------------------------------------------LVPTRGKGSSTSVPPTAT
EGLSTSV---------QPTAGEGSSTSVP---------------PTPGGGLS--------
---------------------------------------------------------T--
------------------------------------------------------------
------S---------VPPTAT--------------------------------------
-----------------------------------------------------------E
DLST--------------------------SVPP-----T---------------PGEGP
ST-SVLP-IPG------E-GLS-TSVPPT-ASD-GS--D---T-SVP---PT-PGE----
G--ASTLVQP----------------TAPDGP--------------GSSVLPNP------
---GEGPSTLFSSSA-----SVDRNPSKCS-LVLPSPRVTKA------------------
----------------S------VDSDSEGP---------------K-------------
-------GAEGPIEFEVLRDCESPNSISIMGLNTSRVAITLKPQDPMEQNVAELL-----
-------QFLLVKDQSKYPIR-ESEMR--EYIVKEYR-----NQFPEILRRAAAH-----
----LECIFRFE---------LRE-LDPEA---------HTYI-----------------
-------L----------------------------------LNKLGPVPFE-----GLE
----ESPNGPKMGLL-------MMILGQIFLNGNQ------AKEA---EIWEMLWRM---
-----GVQ-RER----RLSIFGNPKRLLSVEFVWQ------RYLDYRPV-TDCKPVEYEF
----FWGPRSHLETT--KMKILKFMAKIYNKDPM----D-WPEKYNE---ALEEDAARAF
AEG---------------------------------------------------------
------------------------------------------------------------
----WQALPHFRRPFFEE----------AAAE------------------VAS-PD----
-SE---------------------------------------------------------
---------VSSY-------------------------S---------------------
---------SKYAPH-SWPESRL---ESKARKLVQ------LFLLMD-STKLPI--PK--
------------------------------------------------------------
----KGI---LYYIGRECSKVFPDLLNRAARTLNHVYGTELVVLDPRNHSYT-LYNRREM
EETEEI-VDSPNR-PGNN---FLM----------QVLSF----------IF--------I
-MGNH----A-R--ESAVWAFLRGLGVQ--AGRKHVI--------TCRYLSQR-------
---------YIDSLRVPDSDP---V--QYEFVWGPRARLETSKMKALRYVARIHRK---E
------PQDWPQQYREAMEDEANRADVGHR-QI----------FVHNFR-----------
------------------------------------------------------------
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--------------------------------------MPRGQK---NKLNTPEKR-HQA
-PS-----GTPGL-----------------------------------------------
-KG-------------AQATATKK------------------------------------
-----------------------------------------------------------E
-SFS-------------------------SSPSP-----P---------------CGILS
QRKP-G------------------------AKSHS-------T-------LKRPQR---D
L--STTTLSA-G------------------------------------------------
------------------------------------------------------------
-----------------VS----HTRSYKGA---------------NG-K-IG-KEQ---
-----------------------------SS-SQAPLSIVQSQRDRLTKTTNILV-----
-------EFLMHMYKRKKPVM-KADML--KIINKKYK-----SRFIEILKRASFS-----
----MEVVFGID---------LKE-VDPTK---------HSYI-----------------
-------L----------------------------------VSKMSL-PNN----GTVS
----RGRGFPKTGLL-------MNLLGLIFMKGNC------ATEE---KIWEFLNKM---
-----RVY-AGK----RHFIFGEPKKLITHDLVKL------KYLEYRQV-PNSNPARYEF
----LWGPRAHAETS--KMRVLEFWAKINNTVPS----A-FQSWYEE---ALRDEAKRVQ
AT-VTARADAN-AM----------------------------------------------
----------------------------------------------------------AR
--------------------GCSSVL-----------------------SSS---SSHTY
------------------------------------------------------------
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------------------------------------------------------------
------------------LSL--VSQNSRR--RSSAK---ATA-----------------
----------HNSSIRGEMQAPNAPGLPAAMPGPDVPEGPSDPQILQ-GLCAP-------
---EG-----------------PGT------------SVPST------------------
---------------PGEGAST---------SVPPAAS---EGSSSSGPPTV-SEG-PNI
DLSIAA---------------S-ER----PNSPLPPTAS---------------------
-----EGSSTSEH-----------------------------------------------
----------------------------PSVAEGLHTTELPLF--------NEGPSSSVP
PTSGEGLSTY-------------------LSLTSGEGSSTSVP------P--IAASEGLS
ISVSPTSGEELN--------TL-----------------------------------LSP
T------VSEGSGIKVPPFSGEGLSTSAPPTPG---------------ESRS--------
------------------------------------------------------------
------------------------------------------------------------
----TSV---------LPPSDEGRSIFTP---------------PTPGEGP---------
------------------------------------------------------------
------------------------------------------------------------
----STS---------VAL----T------------------------------------
-----------------------------------------------------------A
FEKP-----------------------------IASVLLP---------------SGNSS
CV-LGLP--TS------GEGPS-TSRMSSATE--GF--G---T-SGM---HT-ASE----
N--PGALLS---------------------------------------------------
------------SRA-----SGSPHSSKCS-LA---------------------------
------------------------SVDSEGP---------------K-------------
-------GAEGPIEFQVLRDHKNSNSITIMGLGTSQVALTLKPQDPMEQNVAELL-----
-------QFLLVKDQSKYPIR-ESEMR--QHIVKEYR-----NQFPEILRRAAAH-----
----LECIFRFE---------LRE-LDPEE---------RTYI-----------------
-------L----------------------------------LNKLGPVPFE-----GLE
----DSPNGPKMGLL-------MMILGEIFLNGNQ------AKEA---EIWEMLWRM---
-----GVQ-RER----RLSIFGNPKRLLSVEFVWQ------RYLDYRPI-TDCTPVEYEF
----FWGPRSHLETT--KMKILKFMAKIYNKDPM----D-WPEQYNE---ALEEDAIRDA
ADD---------------------------------------------------------
------------------------------------------------------------
----WQAVPHFRRPFFEE----------IPAD------------------LLS-PD----
-AD---------------------------------------------------------
---------VSGY-------------------------P---------------------
---------SKYPPH-SWPESRM---EGKSRKLVQ------LFLLMD-STKLPI--PK--
------------------------------------------------------------
----KGI---LYYIGRECSKVFPDLLNRAARTLNHVYGTELVVLDPRNHSYT-LYNRREM
EDAEEI-VDSPNR-PGNN---FLM----------QVLSF----------IF--------I
-MGNH----A-R--ESAVWAFLRGLGVQ--TGRKHVI--------TCRYLSQR-------
---------YIDSLRVPDSDP---V--QYEFVWGPRARLETSKMKALRYVARIQRK---E
------PQDWPEQYREAMEEEANRAQAGHR-QI----------LIHNVR-----------
------------------------------------------------------------
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--------------------------------------MPRGQK---SKLRAREKR-RKA
-RE-----ETQGL-----------------------------------------------
-KV-------------AHATEAEK------------------------------------
-----------------------------------------------------------E
-ECP-------------------------SS-SP-----V---------------LGDIP
TSSL-A-------------------------AGI----------------PQKPQG---A
P--PTTTAAAA-------------------------------------------------
------------------------------------------------------------
-----------------VS----CTKSDEGA---------------KC-Q-GE-ENA---
-----------------------------SF-SQATTSTESSVKDPVAEEAGILM-----
-------HFMLHKYKMREPIM-KADML--KVVDEKYK-----DHFTEILNGASRR-----
----LELVFGLD---------LKE-DNPSG---------HTYT-----------------
-------L----------------------------------VSKLNL-TND---GNL-S
----NDWDFPRNGLL-------MPLLGVIFLNGNS------ATEE---EIWKFMNML---
-----GAY-DGE----EHIIYGEPRKFITQDLVQE------KYLKYKQV-PNSDPPRYQF
----LWGPRAYAETT--KMKVLEFLAKMNGSTPR----D-FPSHYEE---ALRDEEERAQ
VR-SSVRARHR-TTAT--------------------------------------------
--------------------------T-------------------------------FR
--------------------ARS--R-----------------------APFG-RSSHPM
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------------------DDFSLSQTQ--TH-SQVQRNLERRSRDEVNRKVSELV-----
-------QFLLVKDQKKIPIK-RVDIL--KKVIREYK-----DVYSEIVNQAGRI-----
----LQQVFGLQ---------LVE-IDTKH---------HIYI-----------------
-------L----------------------------------TSNLPRVEGE-----NLK
----RDNQTAKLGLL-------TIILSFIFMKGNS------AKDS---AVWEFLRRL---
-----RVH-PGE----KHEVFGDVKKLVTEEFVRQ------K------------------
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--------------------------------------MPRGQK---SKLRARKKR-QQA
-RA-----ETQKL-----------------------------------------------
-GD-------------AQAKAAAE------------------------------------
-----------------------------------------------------------G
-EGS-------------------------SSPPP-----V---------------AEGAS
QCSP-A-------------------------SGT----------------PQQPQR---A
P--VNTN--AAG------------------------------------------------
------------------------------------------------------------
-----------------VS----RRKRDVNA---------------KS-Q-DE-EKP---
-----------------------------ST-SRASTSTWSPRYDHLSRKEGMIV-----
-------QLMLCKYTMQEPIT-KADMM--KLINKKSR-----EHFPEIFRRASER-----
----LDIIFGLH---------LKK-IKPTG---------HSYI-----------------
-------V----------------------------------ISNLEL-NED---GTP-R
----RDSGCPKNGLL-------MPLLSMIFLNGNR------ASEE---EIWKFLNML---
-----GIF-DGK----VHFIFGEPRKLITQDLVQK------QYLEYRRV-PHSQPPRYEF
----LWGPRAQAEIS--KMKVLELLAKMNDITPD----A-LPTLYEE---ALRDEEERAR
------------------------------------------------------------
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---------------------------------------MAQKMDCGAGLLGFQA-----
--------------------------------------------------------EASV
EDSA-LLMQTLM-------EAIQ--IS-EAPPTNQA--TT--------------------
------------------------------------------A-----ASPQSSQPPTA-
N------------------------------------------------EMAD-------
------IQVSAAAARPKS------------------------------------------
-----------------------------AF---------------NVQ-----------
-------------NAT----------------TKGPNGVYDFSQAHNAKEVP-NTQPKAA
F-------------------KSQNATP--KGPNAAYD-------FSQAAAT---------
----GELAANKSEMAFKAQNAT-TKVGPTA---------T-YNFSQSLNANNMANNRPKT
------------------------------------------------------------
----------------------------------------------PFKAWNDTTKAPTA
-------------------------------DTQT-----------QNV-----------
----NQA---KMATSH--------ADIETD--PV---------ISEPDGATAQTSADGSQ
AQNLE--------------------S---------------------------------R
TIIRGKRTRKINNLNV---------EENGSGDQRWAPLAAGTWRSAPVPVTT-QNPPGAP
PNVLWQTPLA----WQNPS----GWQNQTARQTP----P-ARQSPPARQTPPAWQNPVAW
QNPVIWPNPVIWQNPVIWPNPI-VWPGPVVWPNPLAWQNPPGWQTPPGWQTPPGWQGPPD
WQG---PPDWPLPPDW-PLPP-DWPLP-TDWPLPPDWIPADWPIPPDWQNLRPSPNLRP-
-SPNSRASQNLGAAQ-PRDVALL---QERANKLVK------YLMLKD-YTKVPI--KR--
------------------------------------------------------------
----SEM---LRDIIREYTDVYPEIIERACFVLEKKFGIQLKEIDKEEHLYI-LISTPE-
SLAGIL-GTTKDT-PKLG---LLL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPLLGDLRKLLTYEFVKQK-------
---------YLDYRRVPNSNP---P--EYEFLWGLRSYHETSKMKVLRFIAEVQKR---D
------PRDWTAQFMEAADEALDALDAAAA--EAEAR----AEARTRMGIGDEAV-----
------SGP--WSWDDIEFELLT-WDEEGDFGDPWS-RIPF----TFWARYHQNARSRFP
QTFAG---------------------P--IIGPGGTASA------NFAANFGAIGF----
--------FWVE------------------------------------------------
------------------------------------------------------------
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---------------------W-------PDGT-----TPDLRT---LSEN------RQA
-HR-----ETQGL-----------------------------------------------
-AG-------------AQVTQAEN------------------------------------
-----------------------------------------------------------E
-ASS-------------------------SSSSS-----L---------------IPCPM
KGSS-I------------------------SGTPS-------S-------SQCSQS---A
S--FSSTVTT-G------------------------------------------------
------------------------------------------------------------
-----------------TS----LSRSTEGS---------------SS-Q-EEMEKS---
-----------------------------EG-GSTSQDLENLHIDLLDEKVELLI-----
-------SFLLQKYQMREPVT-KADMI--GNVVKEYK-----DDFLEILRSASER-----
----MELVFGLD---------VKE-VDPIS---------HSYT-----------------
-------L----------------------------------ANKLDL-TYN----GMLS
----DQQGMPKTGLL-------IIILGVVFMKGNC------ATEE---EVWKVLNMM---
-----DIY-SGR----KHFIFGEPRRLITSDLVKE------RYLEYQQV-PTSDPPRYEF
----LWGPRAHAEVS--KMKLLEFLAKIHGTNPK----S-FPSQYEE---ALRDEEERAR
AR-IEAAAGTS-AM----------------------------------------------
----------------------------------------------------------AS
--------------------ASS-------------------------------GFSYPY
------------------------------------------------------------
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--------------------------------------MPRGQK---SKRRAREKR-RQA
-RM-----ETKDL-----------------------------------------------
-GN-------------AQAAA---------------------------------------
------------------------------------------------------------
------------------------------TPTP-----T---------------SGSTP
PGSP-P-------------------------AGA----------------GQKPQG---A
A--ATSSLVA--------------------------------------------------
------------------------------------------------------------
----------------GAS----RPRSKARG---------------RR-Q-VKERKN---
------------------------------S-SQASTSAMIAPLGLLAKKAGMLI-----
-------HFMLQKFKLKQPIK-KIDML--KIVHKAFK-----AQFPEILKKATDR-----
----IELVFGLE---------LKE-IKPNG---------YSYT-----------------
-------L----------------------------------VSKERL-AKD----GVLG
----STLEVLKNGLL-------MPLLGVIFLNGNC------ASEA---EVWDFLNAL---
-----GIY-DGK----MHIIFGEPRKFITEELVQE------KYLVYRQI-PDSDPLSYEF
----LWGPRAHAETS--KMKVLEFVAKINSTVPS----A-FPFHYEE---ALREEEERAK
AKSA-SKA----------------------------------------------------
-----------------------------------------------------------R
--------------------GAAKA------------------------------TA---
------------------------------------------------------------
------------H-----------------------------------------------
------------------STVPL---S-DPSSPQ--------------------------
------------------------------------------------------------
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--------------------------------------MPR-----------------GQ
-KN-----ETQGL-----------------------------------------------
-NV-------------PQVTEAEG------------------------------------
-----------------------------------------------------------E
-EAP-------------------------CCSSS-----V---------------SGGAA
SSSP-N-------------------------SGPS-------E-------AQKPQR---A
S---TTAAVAAA------------------------------------------------
------------------------------------------------------------
----------------GVS----STKSKKGA---------------KSRQ-GE-KNA---
-----------------------------SS-SQTSTSTESSSEDPLTRKAGMLV-----
-------QLLLYKYKIKESVT-KGEML--KIVGKRFR-----EHFPEILKKASER-----
----LNLVFGLE---------LNK-VNPNG---------HTYT-----------------
-------F----------------------------------N-KVDL-TDE---ESL-L
----SSFDLPRSRLL-------MPLLGVIFLNGNS------ATEE---EIWEFLNML---
-----GVY-DGE----EHSVFGEPRKLITQDLVQE------KYLEYKQV-PNSDPPRFQF
----LWGPRAYAETS--KMKVLEFLAKVNGTIPC----A-FPTLYEE---ALKDEEKAGV
------------------------------------------------------------
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-------------------------------------MSSHG-Q----------------
-----------------KRQ-HHKDK-G----------------EPKA----QRE-APS-
-------------LNGVQVLRPEE------------------------------------
-----------------------------------------------------------E
G-SS-----------------------SA---CISSRSTPTLS-----------------
------------------------------------------------------------
----KVPC-------------PEPL-ICA-------------------------------
------------------------------------------------------------
QVPERSSA---LSVATA-P--TPGLPFFH----------------L-SSS-QEAEGR---
------------F------SWKNLK------------GHRSLLGDPLDEKMADLV-----
-------QFLLLKYRMKELTT-KAEML--SSVIKNNQ-----EDFPVVFSVASEC-----
----MHLVFGIH---------VEE-VDPSN---------HSYA-----------------
-------V----------------------------------VNALGL-TYD----GMQG
---DD-QSMPKTGLL-------VIILCIIFMVGDR------ACEQ---DVWEMLSVM---
-----GVY-PER----EHFIYGEPRKLITEDLVQE------QYLEYRRV-PGSDPACYEF
----LWGPRARAETS--KMKVLEYWTQVHGSDPR----S-YPFLYEK---ALRDEAECAK
VSNVARATRVP-------------------------------------------------
------------------------------------------------------------
-----------------------RG--------R----------------PRS-----R-
------------------------------------------------------------
---------KHG---------------------RXXX-----------------------
------------------XXXX------XXX-------------------------XX--
------------------------------------------------------------
----XXX-----------------------------------------------------
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--------------------------------------MPRGQK---STLHAREKC-QQT
-RG-----QTQDH-----------------------------------------------
-QG-------------AQITATNK------------------------------------
-----------------------------------------------------------K
-KVS-------------------------FSSPL-----I---------------LGPTI
QKKS-A------------------------GRPGS-------A-------LKKPQR---A
L--ATT-TSV-D------------------------------------------------
------------------------------------------------------------
-----------------VS----YKKSYKGA---------------NS-K-IE-KKQ---
-----------------------------SF-SQGLSSTVRSRTDPLTMKTNMLV-----
-------QFLMEMYKMKKPIM-EADML--KIVQKSHE-----NLFPEILKKAAFN-----
----MEVVFGVD---------LKK-VDSTK---------DSYV-----------------
-------L----------------------------------VSKMDL-PNN----GTVT
----RGRGFPKTGLL-------LNLLGVIFMKGNC------ATEE---KIWEFLNKM---
-----RIY-DGK----KHFIFGEPRKLITQDLVKL------KYLEYRQV-PNSNPARYEF
----LWGPRAHAETS--KMKVLEFWAKVNQTVPS----A-FQFWYEE---ALRDEEERVQ
AT-AMLNDGSS-AM----------------------------------------------
----------------------------------------------------------GR
--------------------KRSKAK-----------------------ASS---SSHA-
------------------------------------------------------------
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---------------------------------------------------METQFRRGG
LGCSPASIKRKKKREDSG--DLGLQVSTMFSEDDFQST---ERAPYGPQL----------
---------QWSQDLPRVQVFRE----------QANLE---DRSPR-RTQRITGGEQV--
-----------------LWGPITQIFPTVRPADLTRVIMPLEQ-----------------
-----------------RSQ-HCKPE-E----------------GLQA----QEE-DLG-
-------------LVG-AQALQAE------------------------------------
-----------------------------------------------------------E
Q-E---------------------------------------------------------
------------------------------------------------------------
---AAFFSSTLN----VGT--LEE------------------------------------
---------LP--------------------------------------AAES---PSPP
QSPQEESF---SPTAMD-A--IFGSLSDE----------------GSSS--QEKEGP---
------------S------TSPDLI------------DPESFSQDILHDKIIDLV-----
-------HLLLHKYRVKGLIT-KAEML--GSVIKNYE-----DYFPEIFREASVC-----
----MQLLFGID---------VKE-VDPTS---------HSYV-----------------
-------L----------------------------------VTSLSL-SYD----GIQC
---NE-QSMPKSGLL-------IIVLGVIFMEGNC------IPEE---VMWEVLSIM---
-----GVY-AGR----QHFLFGEPKRLLTQNWVQE------KYLVYRQV-PGTDPACYEF
----LWGPRAHAETS--KMKVLEYIANANGRDPT----S-YPSLYED---ALREEGEGV-
------------------------------------------------------------
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-----------------------------------------------------MSEQSKD
LSD---------------------------------------------------------
------------------------------------------------------------
--------RNF----------------------------A---------------AEV-P
SSEV--------------------------HSS-----------------PGVPEG---V
P--PS-----ET---------LAEPQSPPLGP------------T---------------
----AAPQAA--------------------------------------------------
------QPP--------------QVPSDEGD---------PKAL-QQA-A-EE--GR---
----------------------AHQAP----SAAQPG-PAPPAPAQLVQKAHELM-----
-------WYVLVKDQKKMIIW-FPDMV--KDVIGSYK-----KWCRSILRRTSLI-----
----LARVFGLH---------LRL-TSLHT---------MEFA-----------------
-------L----------------------------------VKALEPEELD-----RVA
----LSNRMPMTGLL-------LMILSLIYVKGRG------ARES---AVWNVLRIL---
-----GLR-PWK----KHSTFGDVRKLITEEFVQQ------NYLKYQRV-PYVEPPEYEF
----FWGSRASREIT--KLQIMEFLARVFKKDPQ----A-WPSRYRE---ALEEARALRE
ANPTA----------------------------------HCPRSSVSED-----------
------------------------------------------------------------
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---------------------------------------MSDT-----------------
---------------ND-SGA----------------------------GSACFQTKASE
KDSG-SVMQTLL-------IVTQ--NLEVSETPKVS------------------KT----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------PEISEAAKVS-------EALGVS---------------KAI-----------
-------------KV---------------------------SKAPEAQEAP-ANQSSPT
-TQLTDTQVPTA----EN--KSPAADT--KTQNTDLR-------AATVPAT---------
----ETKK-----VSC--------------------------------------------
------------------------------------------------------------
--------------------------------------------------------VA--
-------------------------------DMKV-------------------------
----N-T--KASETEA--------AASQSQADE-----------PEHEGATAQAQENQDT
RPKVK--------------------A---------------------------------K
KARKVKHLEEEEDGS---------------SDQSQTSGTTGGRRVSKALMASMAKRASRG
PIAFWARRAS----RTRLA----A------------------------------------
------------------------------------WARRALL----SLRSPKARRGKAR
RRA---------------------------------------------------------
-AKLQS-SQEPEAPP-PRDVALL---QGRANDLVK------YLLAKD-KTKIPI--KR--
------------------------------------------------------------
----SDM---LKDIIKEYTDVYPEIIERAGYSLEKVFGIQLKEIDKNDHLYI-LLSTLEP
TDAGIL-GTTKDS-PKLG---LLM----------VLLSI----------IF--------M
-NGNR----S-S--EAVIWEVLRKLGLR--PGIHHSLFGDVKKLITDEFVKQK-------
---------YLDYARVPNSNP---P--EYEFFWGLRSYYETSKMKVLKFACKVQKK---D
------PKEWAAQYREAMEADLKAAAEAAA--EAKAR----AEIRAQMGIGLGSE-----
----NAAGP--CNWD-------------EADIGPWA-KARIQAGAEDKAKAQESG--GAS
ASASAST------G----TSTSAGASA--SGGFSAGASLTATLTFGLFTGLGGAGASTSG
NSGACG-FSYK-------------------------------------------------
------------------------------------------------------------
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------------------------------------------

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------------------------------------------------------------
--------------------------------------MPRGQK---SKLRAREKR-QRT
-RA-----QTQDL-----------------------------------------------
-KV-------------GQATAAEK------------------------------------
-----------------------------------------------------------E
-ESP-------------------------SSSSS-----V---------------LGDTP
SSSL-A-------------------------LGI----------------PQKPQR---E
P--RTTPAAAAMSGTG--------------------------------------------
------------------------------------------------------------
--------------------------PDEGE---------------DS-Q-DEENA----
-----------------------------SS-SQASTSTERSLKDPLTRKTKMLV-----
-------QFLLYKYKMKEPTT-KAEML--KIISKKYK-----EHFPEIFRKVSQR-----
----TELVFGLA---------LKE-VNPTT---------HSYI-----------------
-------L----------------------------------VSMLGP-TND----GNQS
----SAWSLPRNGLL-------MPLLSVIFLNGNC------AGEE---EIWEFLNML---
-----GIY-DGK----RHLIFGEPRKLITQDLSLC------RNQQD-ES-PGV------F
----GQGE----------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
--------------------------------------------------------MAE-
----------------------------------------------------------GT
YS-----V-Q-------SGNSNVEDMDEGSHQVR--EEEMVGGNDYE----EFGAFGGYG
TLTSFDIHL--LRAFGTLG-----------------------------SGFHILANEPWE
LENP-VLAQTLV-------EALQ--LDPETLANETEARAA-------------NVARSAA
---S----------NRA-ARAA--------------------ATAARRSFTQV---VANH
L-------------------------------------------------VPT-------
------QLATGDSAQPMTYAE---AQ--------------------GPTPEAILASPPKS
QM---SQMSVISEMAAPGAPTI-STQSQTAS---------------LDHQ-AA-------
--------AEGPGT--------------------IPSTACVFSQAPSASETD-ATWPQAA
FLGQ----------------------------KDVFD-------FTQPAGV---------
----SGMAFTRPKRPAPSQEA--ATEDPSA---------AS-GVPQAASAKEVAATRPKT
T-----------------------------K-----------------------------
------------------------------------------------------------
--------------------------------------------------------SGKA
VAKTRWVEPQNVAATA--------ATNT-KMATS---------TPEPEGAAA---TAQQS
GE-----------------------P---------------------------------W
ARMGGKRTKKSKHLDDEC--------ESSE-EEREPPPVPATWRASQTPVT---------
---------A----R---------------------------------------------
----------------------------------------AQVG----------------
-----------------PRPI-----------------------------M----A----
-PRPQTPSRHILCLP-PRNVTLL---QERANKLVK------YLMIKD-YKKIPI--KR--
------------------------------------------------------------
----SDM---VKDVIREYDEHFPEIIERATYTLEKKFGIHLKEIDKEEHLYI-LVCTQDS
SAR-LL-GKTKDT-PRLS---LLL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPFLGDLRKLITDDFVKQK-------
---------YLEYKKVPNSSP---P--EYEFLWGLRACHETSKMRVLRFIAQNQNR---D
------PREWKAHFLEAVDDAFKTMDMDMA--EEHAR----AQMRARMNIGDEAL-----
------IGR--WSWDDIQAELLT-WDEDGDFGDAWA-RIPF----AFWARYHQYILNSSR
ANRRA------TWRAGVSSGTNGGASTSILDGPSTS-ST---IRTRNAARAG--------
----ASFFSWIQ------------------------------------------------
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---------------------------------------MAQKMDCGAGLLGFQ------
-------------------------------------------------------AEASV
EDST-LLMQTLM-------EAIQ--IS-EAPPTNQA--T---------------------
-------------------------------------------AAGPNASPQSSQPPTA-
S------------------------------------------------EMAD-------
------IQVLAAAARPKT------------------------------------------
-----------------------------AF---------------KAQ-----------
-------------NAT----------------TKGPNGAYDFSQALNAKDMP-NAPTKAA
F-------------------KSQNAAP--KGPNAAYD-------FSQAATT---------
----SELTANKSEMAFKAQSAT-TKVGQNN---------T-YSFSQSLSASEVANTQPKT
------------------------------------------------------------
----------------------------------------------AFKAWNDTTKAPTV
-------------------------------DTQI-----------QNI-----------
----NQA---KMATSQ--------TEVET--NPG---------IPESDGAAAQTSADGSQ
AQNLE--------------------S---------------------------------R
TIIRGKRTRKINNLNV---------DENSSGDQRRAPLTAGTWRSAPVPVTT-QNPPGAP
PNVLWQTPLA----WQNPS----GWQNQPARQTP----P-ARQSPPARQTPPAWQNPVAW
QNPVIWPNPVIWQNPVIWPNPI-VWPGPVVWPNPLAWQNPPGWQTPPGWQTPPGWQGPPD
WQG---PPDWPLPPDW-PLPP-DWPLP-TDWPLPPDWIPTDWPVPPDWQNLRPSPNLRP-
-SPNSRASQNLGASQ-PRDVALL---QERANKLVK------YLMLKD-YTKVPI--KR--
------------------------------------------------------------
----SEM---LRDIIREYTDVYPEIIERACFVLEKKFGIQLKEIDKEEHLYI-LISTPE-
SLAGIL-GTTKDT-PKLG---LLL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPLLGDLRKLLTYEFVKQK-------
---------YLDYRRVPNSNP---P--EYEFLWGLRSYHETSKMKVLRFIAEVQKR---D
------PRDWTAQFMEAADEALDALDAAAA--EAEAR----AEARTRMGIGDEAV-----
------SGP--WSWDDIEFELLT-WDEEGDFGDPWS-RIPF----TFWARYHQNARSRFP
QTFAG---------------------P--IIGPSGTASA------NFAANFGAIGF----
--------FWVE------------------------------------------------
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------------------------------------------

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------------------------------------------------------------
------------------------------------------------------------
--------------------------------------MLHS-W----------------
-----------------KSQ-CDVLE-V----------------GLQA----GKE-AQG-
-------------LVGAQVPVAEE------------------------------------
-----------------------------------------------------------E
A-----------------------------------------------------------
------------------------------------------------------------
---SASSLCPLT----QGP--SEAV---P---------------------AAG-------
----------T--------------------------------------RSVP-------
RRSQRAR----SSVAVA-A--IPLSKSNE----------------G-CSR-Q-AEGV---
------------ST----------------------------SQAVLNKKVAKLL-----
-------QFLSVKYVKQEPIT-KAEML--RNVIKEHK-----DHFPAIFSKACEC-----
----MEVVFGIE---------VKE-VDPTS---------HSYV-----------------
-------L----------------------------------VKTLDL-TYA----GMLS
---D-DQRVPKAGLV-------VLILGVIFMQGNR------APEE---KIWEVLSVI---
-----GMY-AGQ----EDFVYGETKKLITKELVEE------KYLE-RQV-PDSDPPHCEF
----LWGPRAHAESS--KMKVLEFFAKIDETDPT----A-FSRWYEE---ALRDEKKRAQ
ARAAAGANTSA-------------------------------------------------
------------------------------------------------------------
-----------------------MA--------S----------------GSS----SV-
------------------------------------------------------------
---------MPS---------------------SLSC-----------------------
------------------PE----------------------------------------
------------------------------------------------------------
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---------------------------------------MDRRNDYGYRVPPFQ--G---
--------PLPPP--GSLGLP----------------------------FPPDIQTETTE
EDSV-LLMHTLL-------AATK--DSLAMDPPVVNRPKK-------------SKTKKAP
IKAI----------TKA-APA--APPVPTANEIATNKPKITLQALNLPVITQISQASPT-
T------------------------------------------------EVTN-------
------TQVSSVTAQPKKANKMKRVTAKAAQG-SQSPTGREGGATQLNSPLQVLNLPVIS
QNIHV---PIANESASSQTL-ITSIKPKKAS---------------KAK-----------
-------------KAA----------------NKAIASVTEVSLAPTATHTA-TTQGQIT
-NETASIHTTAASIRTKKASKARKTIA--KVINTDTD-------HIEAANV---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------TETAA
RQIEA--------------------S---------------------------------V
VAIRPKKSKGKKAASRGP---------N------------SVSEISEALLATQMVTNQAL
AATLRVKRGS----RARKA----STKARATESQT----PNADQGTQAKMASAQ-TNVSAL
ETQ------------VA------------AAVQALADDYLAQL----SLEPTTRTRGKRN
RK-----------------------------------------------SKHLNGDERS-
GNNYRRIPWSRRPAP-PRDVAIL---QERANKLVK------YLLVKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LRDVIQEYDEYFPEIIERASYALEKMFRVNLKEIDKQSSLYI-LISTRES
SAG-IL-GTTKDT-PKLG---LLM----------VILSV----------IF--------M
-NGNK----A-S--EAVIWEVLRKLGLH--PGVRHSLFGEVRKLITDEFVKQK-------
---------YLEYKRVPNSRP---P--EYEFFWGLRSYHETSKMKVLKFACKVQKK---D
------PKDWAVQYREAVEMEVQAAAVAVA--EAEAR----AEARAQMGIGEEAV-----
------AGP--WNWDDMDIDCLT-REELGDDAQAWS-RFSF----EIEARAQENADASTN
VNFSRGAGTRAGFSDGASISFNGAPSS--S----G-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------GPGITFGGAPSSSASFGNTASISFGGTLSTSS----------------
--------------------SFS------------------S----------------AA
SISFGGAPSTSTSFSSEASISFGGTPCTSASFSGGVSSSFSGPLN--S-ATFSGAASSGF
GG------------------TL-STTAGFSGVLSTSTSFGSAPTTNTVFSSALSTNTGFG
GTLSTSVCFGGSPSSSGSFGGTLSTSICFGGSPCTSTGFGG----TLSTSVSFGGSSSTS
ANCGGTLSTSICFDGSPSTG-AGFGGALNTSASFGGALNTS-------------------
-------------------------------------------------AGFGGAMSTSA
NFGGTLSTSVCFGGSPGTSVSFGGALNTSAGFGGAVSTSTDFGG----------------
------------------------------------------------------------
-----TLSTSVC------------------------------------------------
----------------------FGGSPSTSAGFGGALNTNASFGCAISTSAGFSGAVGTS
AGFSGVPSTNPGFGGAFNTNAGFGGALSTTTDFGGTPSNSIGFGAAPSTSVSFGGAHSTS
LCFGGASSTSLCFGSASNTNLCFGGPPSTSACFSGATSPSFGDGPSTSTSFSFGNGLSTS
AGFGGGLNTSAGFGGGLATSAGFSGG------------------------------LSTS
SGFDGGLGTSAGFSGGPGTSTGFGGGLGTSAGFSGGLGTGAGFGGGLVTSDGFGGGLGTN
ASFSSTLGTGAGFSGGLSTSDGFGGRPNASFDRGLSTIIGFGSGSNTSTGFTGEPSTSTG
FNSGPSSIVGFNGGPSTGVGFCSGPSI-SGFSGGPSTGAGFG------------------
------------------------------------------------------------
-------GGPNTGVGFGGG-LSTSAGFSSGATSLGACGFSYG

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------MAE-
----------------------------------------------------------GC
R--------D-------PQSCKTEEMDPDSHGVLP-EDQVVGGQDCE----ELCALGEYE
SFLNFHMRL--PHNLGSLG-----------------------------AGLRLLSAEPWE
LDPG--LAQTL--------IALQ--LDPETLANEAEERAA-------------NVARTAA
---S----------SRA-TQA--------------------MAEAARATFHQV---VSEQ
L-------------------------------------------------MTP-------
------PQDPGHSAPDPTDRTAVQPQ--------------------GATPGTALACVHMS
------QMLVSGQVVALDTPAASCTQPQKAP---------------QAPQ-V--------
-------------QAA----------------GTGPCTVRAFSQAPWTSERA-ATRPLAA
FLSQ----------------------------SDVSD-------FNRPPGV---------
----SGVGFPRPKRPTLVQEA--ATQGPSA---------AS-AVPPASRAWEGPASGPKA
TR-------------------------S--R-----------------------------
------------------------------------------------------------
--------------------------------------------------------SRKA
LAKTWWMEPQKVAEAA--------SAKA-LMAPG---------LPQQAGAAS---STQHS
AE-----------------------P---------------------------------W
ISKGGKRTKKSKHLNSDT--------ENSE-EDREPPVIPPGWRTSEAPLA---------
---------A----L---------------------------------------------
----------------------------------------AQRA----------------
-----------------PWPP-----------------------------L----A----
-MRTQAPSRHVLCLP-TRNVALL---QDRANKLVK------YLMIKD-YKKIPI--KR--
------------------------------------------------------------
----SDM---LKDVIREYDDHFPEITERAAYTLEKKFGIHLKETDKEEHLYI-LVCTRDS
SAR-LL-GKTKDT-SRLS---LLL----------VILGV----------IF--------M
-NGNC----A-S--EAILWEALRKMGLR--PGVRHLLLGDLRKLITEEFVKQK-------
---------YLEYKRIPKSSP---P--EYVFLWGLRVCHKTSKMKVLKFIAQNQNR---D
------PRDWKAQYLEAVEEAFKMMDVGMT--EQQAR----ARMRAQLNIGEEAL-----
------AGR--WSWDDIQVELLT-WDEDGDFGDAWA-RIPF----AFWTRYHQYILNSNR
ASGNA------NWRADATGGTSGGFGAGILDGPSTS-ST---AQRRHATTIG--------
----ADFF-WIQHH----------------------------------------------
------------------------------------------------------------
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------------------------------------------

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------------------------------------------------------------
------------------------------------------------------------
-------------------------------MGNC------LSCQ---------------
-----AGE-ASDNTKRKSHTQ------------YT----QDTSFHLWDD-SEIV------
----SLDCETHAQGEHALM-------CSGSPGQQ----S-YAWSAEG---GNQD----LL
AIKG----LES----A------SPSS----------------------------------
----------------------YRRSY-------------------------------AI
ISA------------------LSK---LYGLEE------DSEDQSTIEMISVA-------
------------------------EMLDP-QCPEGGSS---LPN-TIDVAPPSQSHGA--
---------SSSG-----------------------------------------------
QGEGSFLLPSQEETESLMSGDSG---DNKMAALLQ------FLASKY-LKEEPT--TM--
------------------------------------------------------------
----AEM---QQC-ISKECDNFSVLFREATQSLKLYFGIDVKKVQPSSTFYV-LVPVLGL
TYDGMD-SNRKGY-PRTI---LLI----------IVLGI----------IF--------L
-QGNC----A-R--EEAIWEILSEIGVH--AGEEHCIYGEPRKFITEDLVQEQ-------
---------YISYLVVPNSDP---P--EYKFQWGPRAYAETSKKEVLLFLARLKAT---V
------LRDLPV--------------SEEEDSENEN------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------MSEQSKD
QSD---------------------------------------------------------
------------------------------------------------------------
--------PNF----------------------------V---------------AEA-P
NSGM--------------------------HCS-----------------PGAPVM---L
P--PPASAVAT----------LAGPPSAPEGP------------T---------------
----ASPQAA--------------------------------------------------
------PPP--------------RELGEEDD---------PKAM-QQA-A-EE--GR---
----------------------AHQPQ----SPAQPT-PAPPAPAQLVQKAHELM-----
-------WYVLVKDQKRMVIW-FPDMV--KDVIGSYK-----KWCRSILRRTSLI-----
----LARVFGLH---------LRL-TNLHT---------MEFA-----------------
-------L----------------------------------VKALSPEELD-----RVA
----LSNRMPMTGLL-------LMILSLIYVKGRG------ARES---AVWNVLRIL---
-----GLR-PWK----KHSTFGDVRKLITEEFVQQ------NYLKYQRV-PNLEPPEYEF
----FWGSRASREIT--KMQIMEFLARVFKKDPQ----A-WPSRYRE---ALEEARALRE
ANPAA----------------------------------HCPRSSVSED-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------MAE-
----------------------------------------------------------GS
FS-----V-Q-------SESYSVEDMDEGSDEVR--EEEMVEGNDYE----EFGAFGGYG
TLTSFDIHI--LRAFGSLG-----------------------------PGLRILSNEPWE
LENP-VLAQTLV-------EALQ--LDPDTLANETAARAA-------------NVARAAA
---S----------NRA-ARAA--------------------AAAARTAFTQV---VASH
R-------------------------------------------------VAT-------
------PQVSGEDTQPTTYAA--EAQ--------------------GPTPEPPLASPQTS
------QMLVTSEMAAPGAPVT-STKSQTGS---------------PAQ-----------
-------------EAA----------------TEGPSSACAFSQAPCAREVD-TTRPSTA
FLGQ----------------------------NDVFD-------FTQPAGV---------
----SGMAFPRPKRPAPAQEA--ATEGSSA---------AS-GVPQTGPGREVAATRPKT
T-----------------------------K-----------------------------
------------------------------------------------------------
--------------------------------------------------------SGKA
LAKTRWVEPQNVVAAA--------AAKA-KMATS---------IPEPEGAAA--ATAQHS
AE-----------------------P---------------------------------W
ARMGGKRTKKSKHLDDEY--------ESSE-EEREPPAVPPTWRASQPSLT---------
---------V----R---------------------------------------------
----------------------------------------AQLA----------------
-----------------PRRP-----------------------------V----A----
-PRSQIPSRHVLCLP-PRNVTLL---QERANKLVK------YLMIKD-YKKIPI--KR--
------------------------------------------------------------
----ADM---LKDVIREYDEHFPEIIERATYTLEKKFGIHLKEIDKEEHLYI-LVCTRDS
SAR-LL-GKTKDT-PRLS---LLL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPFLGDLRKLITDDFVKQKNLELREG
TPLSVAPSWYLEYKKIPNSNP---P--EYEFLWGLRARHETSKMRVLRFIAQNQNR---D
------PREWKAHFLEAVDDAFKTMDVDMA--EEHAR----AQMRAQMNIGDEAL-----
------IGR--WSWDDIQVELLT-WDEDGDFGDAWA-RIPF----AFWARYHQYILNSNR
ANRRA------TWRAGVSSGTNGGASTSVLDGPSTS-ST---IRTRNAARAG--------
----ASFFSWIQHR----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------

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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------LPLD-E----------------
-----------------KSS-QCTQD-Q----------------HLHT----QSE-TQR-
-------------LENAQVPKSME------------------------------------
-----------------------------------------------------------E
I-----------------------------------------------------------
------------------------------------------------------------
---FPSFSSLLM----PVR--LNKA---P---------------------AAK-------
----------T--------------------------------------LSTP-------
EGPESSFS---TSIAIT-A--TSSSQPDE----------------SSRTE-EEEKNL---
------------S------TSEDTA------------KPRNMSIDALEKKVAFLE-----
-------SFLLLKYRMKEVAT-KEDIL--KIIIKDDE-----DHFPEIFLRACEH-----
----MEMIYGLD---------VKE-VDPTS---------HCYG-----------------
-------I----------------------------------FIKLGL-TYD----GMLG
---PI-EGLPKTGLL-------ILMLCLIFMHGNR------VCEE---EVWRVLNIR---
-----EIY-SGQ----KHFIYGEPKEFLTNDLVKE------KYLEYRQV-ANSDPARYEF
----LWGPRAHAETR--KMEILEFLAKIHGTDPK----S-YPSQYEE---ALREEEERAQ
A-LSVRAASTS-------------------------------------------------
------------------------------------------------------------
-----------------------MA--------T----------------ASS----SA-
------------------------------------------------------------
---------VSG---------------------SFSE-----------------------
------------------T-----------------------------------------
------------------------------------------------------------
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---------------------------------------MAQKMDCGAGLLGFQSPDA--
--CRAVCHPLPQPPASTLPLSAFPT-LCDPPYSQLRDPPPVLSCYCTPLRASLAPAEASV
EDSA-LLMQTLM-------EAIQ--IS-EAPPTNQA--TA--------------------
------------------------------------------A-----ASPQSSQPPTA-
N------------------------------------------------EMAD-------
------IQVSAAAARPKS------------------------------------------
-----------------------------AF---------------KVQ-----------
-------------NAT----------------TKGPNGVYDFSQAHNAKDVP-NTQPKAA
L-------------------KSQNATP--KGPNAAYD-------FSQAATT---------
----GELAANKSEMAFKAQNAT-TKVGPNA---------T-YNFSQSLNANDLANSRPKT
------------------------------------------------------------
----------------------------------------------PFKAWNDTTKSPTA
-------------------------------DTQT-----------QNV-----------
----NQA---KMATSQ--------ADIETD--PG---------ISESDGATAQTSADGSQ
AQNLE--------------------S---------------------------------R
TIIRGKRTRKINNLNV---------EENSSGDQRRAPLAAGTWRSAPVPVTT-QNPPGAP
PNVLWQTPLA----WQNPS----GWQNQTARQTP----P-ARQSPPARQTPPAWQNPVAW
QNPVIWPNPVIWQNPVIWPNPI-VWPGPVVWPNPLAWQNPPGWQTPPGWQTPPGWQGPPD
WQG---PPDWPLPPDW-PLPP-DWPLP-TDWPLPPDWIPADWPIPPDWQNLRPSPNLRP-
-SPNSRASQNPGAAQ-PRDVALL---QERANKLVK------YLMLKD-YTKVPI--KR--
------------------------------------------------------------
----SEM---LRDIIREYTDVYPEIIERACFVLEKKFGIQLKEIDKEEHLYI-LISTPE-
SLAGIL-GTTKDT-PKLG---LLL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPLLGDLRKLLTYEFVKQK-------
---------YLDYRRVPNSNP---P--EYEFLWGLRSYHETSKMKVLRFIAEVQKR---D
------PRDWTAQFMEAADEALDALDAAAA--EAEAR----AEARTRMGIGDEAV-----
------SGP--WSWDDIEFELLT-WDEEGDFGDPWS-RIPF----TFWARYHQNARSRFP
QTFAG---------------------P--IIGPGGTAGA------NFAANFGAIGF----
--------FWVE------------------------------------------------
------------------------------------------------------------
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---------------------------------------MAQNPDGGAGLRGFQA-----
--------------------------------------------------------EAPV
EDGT-LLVQTLM-------EAIQ--IS-EAPPTNQA--MA--------------------
------------------------------------------AASGQNASPQSSQPPTA-
N------------------------------------------------EVAD-------
------TEVSTAAARPKT------------------------------------------
-----------------------------GF---------------KAQ-----------
-------------N------------------TKGPN---DFSQARHAKEMP-KNQSKAA
F-------------------KSQNGTA--KGPNAASE-------FSQAAGT---------
----GKSAAKKSEMAFKAQN---TKAGPSA---------A-YNFSQSPSANEMANNQPKK
------------------------------------------------------------
----------------------------------------------ATKAWNGTTKVSAA
-------------------------------DAQI-----------QNV-----------
----NQA---KMADIG--------T------SPG---------ISETDGAAAQTSADGSQ
AQNVE--------------------S---------------------------------R
TIIRGKRTRKINNLNV---------EENSSGDQRRASLASGNWRSAPVPVTT-QNPPGAP
QNVLWQTPLA----WQNPS----GWQNQTTRQTP----P-ARQSPPARQTASAWQNPVTW
QNPVIWPNPVIWQNPVIWPNPI-VWPGPIVWPNPMAWQNTAGWQSPPTWQAPPSWQNPQD
WQG---PPDWQLPHDW-SLPP-DWAVP-TDWPFPPDWIPADWPIPPDWQNLRPSPNLRS-
-SPNSRASQNQGPPQ-PRDVALL---QERANKLVK------YLMLKD-YTKVPI--KR--
------------------------------------------------------------
----SEM---LRDIIREYTDVYPEIIERACFVLEKKFGIQLKEIDKEEHLYI-LISTPE-
SLAGIL-GTTKDT-PKLG---LLL----------VILGI----------IF--------M
-NGNR----A-S--EAVLWDALRKMGLR--PGVRHPLLGDLRKLLTYEFVKQK-------
---------YLDYRRVPNSNP---P--EYEFLWGLRSYHETSKMKVLRFIAEVQKR---D
------PRDWTAQFMEAADEALDALDAAAA--EAEAR----AEARTRMGIGDEAV-----
------SGP--WSWDDIEFELLT-WDEEGDFGDPWS-RIPF----TFWARYHQNARSRFP
QAFTG---------------------P--IISPSGTATA------NFAANFGAIGF----
--------FWVE------------------------------------------------
------------------------------------------------------------
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--------------------------------------------------LQQK------
------------------------------------------------------------
------------------------------------------------------------
--------PLHHP----------LPSADAQR---------------QGSQ-E--------
------------------ARGTSSQGG--RR-AEASPEVGPRSQQQLELKVAELV-----
-------QFLLIKDQKKIPIK-RTDIV--KHVIGDYK-----DIFPDLLKLAAER-----
----LEYVFGYK---------LVE-LEPKS---------NTYI-----------------
-------L----------------------------------INTLEPVEED----AEVR
----GDQGTPTTGLL-------MIVLGLIFMKGNT------IKET---EVWDFLRRL---
-----GVY-PTK----KHLVFGDPKKLITEEFVRQ------RYLEYRRI-PHTDPVDYEF
----QWGPRTNLETS--KMKVLKFVAKVHNQDPK----D-WPAQYCE---ALADEEARAR
PETG-GPTPS--S-----------------------------------------------
------------------------------------------------------------
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--------------------------------------MPRGQA---SKRRAREKR-RQA
-RG-----EDQCL-----------------------------------------------
-GG-------------AQATAAEK------------------------------------
-----------------------------------------------------------E
-KLP-------------------------SSSSP-----A---------------CQSPP
QSFP-N-------------------------AGI----------------PQESQR---A
S--YP-SSPASA------------------------------------------------
------------------------------------------------------------
-----------------VS----LTSSDEGA---------------KG-Q-KG-ESP---
-----------------------------NS-FHGPSSSESTGRDLLNTKTGELV-----
-------QFLLNKYIRKEPIT-REAML--KVINRKYK-----QHFPEILRRSTEN-----
----VEVVFGLY---------LKE-MDPSR---------QSYV-----------------
-------L----------------------------------VGKLDF-PNQ---GSL-S
----DGGGFPLSGLL-------MVLLSTIFMHGNR------ATEE---EMWECLNAL---
-----GMY-KGR----KHFIYGEPQELVTKDLVRE------GYLEYQQV-PSSDPPRYEF
----LWGPRARAETS--KMKVLEFVAKLNDTVAS----T-YKSRYEE---ALREEEEQAR
AR-AVARDSAR-AR----------------------------------------------
----------------------------------------------------------AS
--------------------RSF--Q-----------------------P----------
------------------------------------------------------------
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--------------------------------------MSH--S----------------
-----------------ESQ-SHELE-V----------------GLKA----QRE-AQG-
-------------LVAAQVPATEE------------------------------------
-----------------------------------------------------------K
E-----------------------------------------------------------
------------------------------------------------------------
--TASSPLSPLI----QGA--PEVV---P---------------------AAG-------
----------N--------------------------------------PGVL-------
QQSGEACS---SSPAVE-A--TLSSKSNE----------------G-SGR-PRRD-----
-----------------AGASQAPP------------DPAILPDDVLDKMVAKLL-----
-------QFLSGKYVAKKPIT-KAEML--KS-IKEHK-----NHFPVIFKKACEC-----
----MEIVFGLK---------VKE-VDPIN---------HSYV-----------------
-------L----------------------------------IKTLDL-TYD----GMLS
---D-DQGMPKTGLL-------ILILGVIFMEGDH------APED---RIWRVLSEI---
-----GVY-AGR----KDFIYGEPRKLITEDLVQE------KYLVYQQV-PHSDPPRYEL
----LWGPRARAETS--KMKVLQFFSKVTGTDPT----S-FPYWYGE---ALRDERERAR
ATVATTDGTTV-------------------------------------------------
------------------------------------------------------------
-----------------------TA--------S----------------EGS----SV-
------------------------------------------------------------
---------PSG---------------------SFSR-----------------------
------------------PE----------------------------------------
------------------------------------------------------------
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--------------------------------------------------------MAE-
----------------------------------------------------------GS
FS-----V-Q-------SESYSVEDMDEGSDEVR--EEEMVEGNDYE----EFGAFGGYG
TLTSFDIHI--LRAFGSLG-----------------------------PGLRILSNEPWE
LENP-VLAQTLV-------EALQ--LDPDTLANETAARAA-------------NVARAAA
---S----------NRA-ARAA--------------------AAAARTAFTQV---VASH
R-------------------------------------------------VAT-------
------PQVSGEDTQPTTYAA--EAQ--------------------GPTPEPPLASPQTS
------QMLVTSEMAAPGAPVT-STKSQTGS---------------PAQ-----------
-------------EAA----------------TEGPSSACAFSQAPCAREVD-TTRPSTA
FLGQ----------------------------NDVFD-------FTQPAGV---------
----SGMAFPRPKRPAPAQEA--ATEGSSA---------AS-GVPQTGPGREVAATRPKT
T-----------------------------K-----------------------------
------------------------------------------------------------
--------------------------------------------------------SGKA
LAKTRWVEPQNVVAAA--------AAKA-KMATS---------IPEPEGAAA--ATAQHS
AE-----------------------P---------------------------------W
ARMGGKRTKKSKHLDDEY--------ESSE-EEREPPAVPPTWRASQPSLT---------
---------V----R---------------------------------------------
----------------------------------------AQLA----------------
-----------------PRRP-----------------------------V----A----
-PRSQIPSRHVLCLP-PRNVTLL---QERANKLVK------YLMIKD-YKKIPI--KRAG
RQPVPPSPSPSLWASLCLLGCCGWSPLSPQDGVLAAPPSAGLTKGLQLYDACSAQVLSPT
LPPPADM---LKDVIREYDEHFPEIIERATYTLEKKFGIHLKEIDKEEHLYI-LVCTRDS
SAR-LL-GKTKDT-PRLS---LLL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPFLGDLRKLITDDFVKQK-------
---------YLEYKKIPNSNP---P--EYEFLWGLRARHETSKMRVLRFIAQNQNR---D
------PREWKAHFLEAVDDAFKTMDVDMA--EEHAR----AQMRAQMNIGDEAL-----
------IGR--WSWDDIQVELLT-WDEDGDFGDAWA-RIPF----AFWARYHQYILNSNR
ANRRA------TWRAGVSSGTNGGASTSVLDGPSTS-ST---IRTRNAARAG--------
----ASFFSWIQHR----------------------------------------------
------------------------------------------------------------
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-----------------------------------------------------MSEQSKD
MSD---------------------------------------------------------
------------------------------------------------------------
--------PNF----------------------------A---------------AEA-S
NGEL--------------------------QSG-----------------SEIPAG---V
P--PPTSPAAI----------VAEAPIAPEGP------------M---------------
----EAPQAS--------------------------------------------------
------PPP--------------PERLEDID---------PKIL-QQA-I-EE--GR---
----------------------AHQPQ--SPARP--M-PAPPAPAQLVQKAHELM-----
-------WYVLVKDQKRMVLW-FPDMV--KDVMGSYK-----KWCRSILRRTSLI-----
----LARVFGLH---------LRL-TNIHT---------MEFA-----------------
-------L----------------------------------VKALSPADLD-----RVA
----LNNRMPMTGLL-------LMILSLIYVKGRG------AREG---AVWNVLRIL---
-----GLR-PWK----KHPTFGDVRKIITEEFVQQ------NYLKYQRV-PHVEPPEYEF
----FWGSRANREIT--KMQIMEFLARVFKKDPQ----A-WPSRYRE---ALEQARALRE
ANLAA----------------------------------HCPRSSVSED-----------
------------------------------------------------------------
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--------------------------------------MPRGQK---SKLRAREKR-RQA
-QI-----ETQRL-----------------------------------------------
-QD-------------AQATEAE-------------------------------------
-----------------------------------------------------------E
-GSP-------------------------SSPSP-----S---------------FGGSP
KSSP-S------------------------AGSGS-------K-------SQRSRR---A
P--PTTNTSA-G------------------------------------------------
------------------------------------------------------------
-----------------VS----CTRSDEGA---------------KN-Q-DE-ERP---
-----------------------------ST-SQASASTDDPHRTPLDQKAILLV-----
-------EFLLRKYNMRDPIT-KQDMM--RQVIKKHK-----AHFHVILKKASEL-----
----MVLAFGID---------VKE-VDPIR---------HRYV-----------------
-------L----------------------------------VSKLQR-TSD----DRLR
----GEKIMPKTGLL-------MTILCVIFMKANC------AAEE---DIWEVLNVM---
-----GIY-ADK----KHYIYGDANKLITEDFVQE------RYLEYRQV-PNSDPPRYAF
----LWGPRAHAETS--KMKVLEFLAKLHDTVPS----A-FPAWYEE---ALRDEEERAR
AR----------------------------------------------------------
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------------------------------MPR---------------------------
----------------------RHKNK---------------------------------
-YH-----------------ACVKCH-QVQGDTQR---PQEAQTTAAAAPK-E-ECPSS-
-SS-------------------SVP-HGS-PLSSLATGDHQELQ-G-------------A
---------MAPS---S-------------PDAGPSCAGSDEG---------AQG----P
EEESA GASQAAPATQ-STRKDPL---TRKASM LVE------FLLEKD-TKKEPI--SQ--
------------------------------------------------------------
----HAL---LKVVGRNL-----EILRRASKHMELVFGLKLTVVGRSMIIYA-LIYKLNL
GGDEGL--SEEAL-PKSG---FLM----------VLLGI----------IF--------R
-KSNH----A-P--GEDVWEFLSVLGVY--TGRSHWILGEPRRLITKDLVQKK-------
---------YLKYRQVPNGDP---P--HYKFLWGPRA-----------------------
------------------------------------------------------------
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---------------------------------------MAQKMDCGAGLLGFQA-----
--------------------------------------------------------EASV
EDST-LLMQTLM-------EAIQ--ISEAPPTSQAT--A---------------------
------------------------------------------AASGQNASPQCSQLPTA-
S------------------------------------------------EMAD-------
------VQVLAAAARPKT------------------------------------------
-----------------------------AF---------------KTQ-----------
-------------NAT----------------TKGPNDVYDFSQAHSAKEIS-NTQPKAP
F-------------------KPQNATP--KGPNAAYD-------FSQAAAT---------
----SELAASKSEVALFKAQDVTTKVGPNA---------T-SNFSRSPSANEMATNQPKT
------------------------------------------------------------
----------------------------------------------AFKAWNDTTEAPIA
-------------------------------DTQT-------H--SQNV-----------
----NRA---KLATSQ--------ADTETN--PS---------IFEPDGAAAQTSAEGSL
AQNLE--------------------S---------------------------------R
TIIRGKRTRKINNLNV---------EENSSGDQRRAPLAAGTWRAAPVPGTT-QNPPGAP
PNVLWQTPLA----WQNPS----GWQNQAARQTP----P-TRQNPPARQSPPSWQNPIAW
QNPVIWPNPVIWQNPVIWPNPI-VWPGPVVWPNPVAWQNLPGWHTPPGWQNTPGWHGPPD
WQG---PSDWPLPPDW-PLPP-DWPLS-TDWPLPPDWIPADWPIPPDWQNLRPSSNLRP-
-SPNSRASQNLAAPQ-PRDVALL---QERANKLVK------YLMLKD-YTKVPI--KR--
------------------------------------------------------------
----SEM---LRDIIREYTDVYPEIIERACFVLEKKFGIQLKEIDKEEHLYI-LISTPE-
SLAGIL-GTTKDT-PKLG---LLL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPLLGDLRKLLTYEFVKQK-------
---------YLDYRRVPNSNP---P--EYEFLWGLRSYHETSKMKVLRFIAEVQKR---D
------PRDWTAQFMEAADEALDALDAASA--EAEAR----AEARTRMGIGDEAV-----
------SGP--WSWDDIEFELLT-WDEEGDFGDPWS-RIPF----TFWARYHQNARSRFP
QTFAG---------------------P--IIGPSGTASA------NFTANFGAIGF----
--------FWVE------------------------------------------------
------------------------------------------------------------
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--------------------------------------MSQG-Q----------------
-----------------ESP-QDIYD-E-------------------S----FQA-CKA-
-------------LEEAQFSEASE------------------------------------
-----------------------------------------------------------E
A-----------------------------------------------------------
------------------------------------------------------------
---SLS-SSSFI----CGT--LEEA---S---------------------AAE-------
----------A--------------------------------------PSTP-------
QGLQSAYF---SSTAIT------ASKSDE----------------VFSSQ-EEQE-----
-------------------------------------STDNLPTDILGEKVALLV-----
-------QFLLLKYKMKEMIT-KEDML--KMVIKEHK-----DHFPEILSMASER-----
----MELVFGID---------VME-VDHNS---------HCYA-----------------
-------L----------------------------------LNKLGL-TYD----GMVS
---GD-GGIPKTGLM-------IFVLGVIFMKGSR------ATEE---EIWEVLNRL---
-----DIH-SGQ----NHFLYGEPRKFITEDLVRE------KYLEYRKV-FNSDPARYEF
----RWGPRAHAEIS--KVTLLEFLAKINDSDSP----I-FSSRYEE---ALRDEEKRAR
NAFISRVKSTT-------------------------------------------------
------------------------------------------------------------
-----------------------RT--------S----------------NHL----RR-
------------------------------------------------------------
---------MMGS--------------------SLSP-----------------------
------------------------------------------------------------
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------------------------------------------------------------
--------------------------------------------LRG---ASSGHEKEES
L-------------------ALPAVSVRTVRPE---------------------------
----------------------GTT----------------------------------H
--------------------TRVKANAQTEKPCSEG--IGLSQAAAATRQEPS-SSSSP-
---------------------RVKSTQRG-SRAAGTPSTPQGPQ-R-------------A
---------PSTS---T-------------PAAAIPNARSNEG-------------ASNQ
AQEIPSS SQAQSA-I-QLRRSPF---DEKIAL MVY------YLLYKY-QMKEPV--TK--
------------------------------------------------------------
----GDM---LRNVVLVYRNHFPEILKRAAHYLELIFGLDMKEVDPNRHTYV-LVNKLEL
GYNERL-SDDRGF-PKTG---FLM----------TILGL----------IF--------Y
-KGNS----A-T--GQQICEVLNMMGVH--VGRSHFIYGEPRKLI-IDMVKEK-------
---------YLEYQQVPNSDP---P--SYKFLWGPRAYAETSKMKVLEFLAKIYNT---V
------PTAFPVMYEEAVRDEEERI-----------------------------------
------------------------------------------------------------
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------------------------------------------

------------------------------------------------------------
------------------MSL--VSQNSRRRRGGRGN---SR------------------
--------------------NSKGKGLPAAVPGPDVPKDPSDPQILQ-GLCAS-------
---EG-----------------PGT------------SVMPT------------------
---------------PREGPNT---------SVSPTAS---EGSSATGQLII-SKG-LNT
SELPIS---------------G-EG----PGTSRPPAVS---------------------
-----AGLNTAMSITAAEGPS------TSVPPTAPRGSKA---SE-------HPDVSEGL
NI----------------------SE-QPRSDEGP--GVQPTL--------GEGLGTSVP
PTFSEESGIS-------------------VPLPSGKGLSAS-------VS--PTVSEGPG
INLPSPASEALS--------TS---VP-----PTASDG------------LG---INLLP
T------PAEGPSTSVLLSVLEEPDISASPPSA---------------EGLSIS------
------------------------------------------------------------
------------------------------------------MPPPSGEVQSTWVPPTIL
EGSRVKA---------PPTSKKGLRISVP---------------PAAPESLST-------
------------------------------------S---------------AKGGGTSR
----------RSI----------------------------------------------A
AEGFSIS---------A-AS----------------------------------------
------------------------------------------------------------
---C------------------------AAEGSATCGLLP---------------CIEGP
STSGLH---IL-------EEDH-TSQMPLGAEGLSA--S---G---M---ST--------
---------------------------AADNP----------------------------
------EA-PLSCGA-----AVGIDLCKCASLALQK------------------------
-----------------------DSGPVVRP---------------K-------------
-------RSEGFLDFQVLRDSKNSNSITIMGLGTAHVALTLKPQDPMEQNVAELL-----
-------QFLLVKDQTKYPIK-ESEMR--QFIVKEYR-----NQFPEILRRAAAH-----
----LECIFRFE---------LKE-LDTEE---------HTYI-----------------
-------L----------------------------------LNKLGPVPFE-----GLE
----DIPNGPKMGLL-------MMILGQIFLNGNQ------AREA---DIWEMLWRF---
-----GVQ-RER----RLSVFGNPKRLLSVEFVWQ------RYLDYRPI-TDCVPVEYEF
----YWGPRSHLETT--KMKILKFMAKIYNKDPM----D-WPAQYNE---ALEEDANR-V
GGD---------------------------------------------------------
------------------------------------------------------------
----WRAVPHFRRPFFEE----------VSPE------------------LLA-PD----
-SD---------------------------------------------------------
---------APGC-------------------------P---------------------
---------SKYSPH-SWPESRL---ESKSRKLVQ------LFLLMD-STKLPI--PK--
------------------------------------------------------------
----KGI---LYYIGRECSKVFPDLLNRAARTLNNVYGTELVVLDPRNHSYT-LYNRREM
EDIEEI-VDSPNR-PGNN---FLM----------QVLSF----------IF--------I
-MGNH----A-R--ESAVWAFLRGLGVQ--NGRKHVI--------TCRYLSQR-------
---------YLDSLRVPDSDP---V--QYDFVWGPRARLETSKMKALRYVARIHRK---E
------PQDWPDQYREALEDEANRAEA-HR-PL----------VVRNLR-----------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------MAE-
----------------------------------------------------------GS
YS-----V-Q-------SGSYAVEDMEEGRGEAGR-EEEMVEGNDYE----EFGAFGGYG
ALTSFDIHL--LRAFGSLG-----------------------------SGLRILSNEPWE
LENP-VLAQTLV-------EALQ--LDPDTLANETAARAA-------------NVARSAA
---S----------NRA-ARAA--------------------AAAARRSFNQV---MGNH
R-------------------------------------------------QPT-------
------PQASGRVSQPVPDAET------------------------------PPASPQIP
FPV-LWPLLLLLQGAGPPRPSRSLLPP-TPS---------------LLS-----------
--------------RV----------------SDGPPPSCAP------------------
-------------------------------------------------GL---------
----VG-----RKRPA---------QGPGI------------------------QRRAPA
QH-------------------------I--S-----------------------------
------------------------------------------------------------
--------------------------------------------------------RGRL
LRLLLWLLPAEGWGRG--------PGRSGTGSPG---------NPCVLSLCA--------
NE-----------------------C---------------------------------K
FQAPGTR---------NM--------R-AGEEEEESPVAGPTDLESKPPLP---------
---------A----R---------------------------------------------
----------------------------------------AQVA----------------
-----------------PRPP-----------------------------M----A----
-ATSQIPSRHVLCLP-PRNVTLL---QERANKLVK------YLMIKD-YKKIPI--KR--
------------------------------------------------------------
----SDM---MKDVIREYDEHFPEIIERATYTLEKKFGIHLKEIDKEEHLYI-LICTRDS
SAR-LL-GKTKDT-PRLS---LLL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGYDWPLG-SCPPVLNSSSITLR-------
---------YLEYKKIPNSSP---P--EYEFLWGLRARHETSKMRVLRFIAQ--------
------------------------------------------------------------
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------------------------------------------

------------------------------------------------------------
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-------------------------------------QSPPQIPVTSSFTS---------
TLLSVFQSSAESTQSTFEGF--PQSPPQIPVTSSFTSTLLSVFQSSPESSQSTFEGFPQS
PLQIPVTSSFPSTLLSVFQSSPDSTQSTFEGFPQSPLQIPLSSSSSSPLLSLFQSSPESS
QSTFEGFAESPLQIPQSPPEGDNSQSPLHSPQSSPEGEDS------EAPFQSPPEGENAL
SPLQIPQNPPEWEDS------LSRLQIHMCPPDGEDSQSPLQI----PESSPEGD-----
-DSQSPLQKPQSPPDGEDSLSPLQISQS---PPEGEDIQSPLQNPASSSISSTLL----S
LFHSSPESTQSP---FEGFPHSPLQIPVSPSFSSTLLSLFQSSPESSQSTFEGFVQSPLQ
IPQSSPV-TICSSSTSLSLPQSFPESPQSPPEGPAQSPLCSPQSLPEGTDSQSPLQRPQS
PPEGEDSLSPLYIPQSPPEGEDSLSSLQYPHSP----------------PVREASLSPLQ
I--HPCTTDGKDPQSPLQTPQSPPEWEVSLSPLRFPH-----SPPQGEDFQSSLQSPISI
CSSSTSLSLPQSFPESPQSPPEG-PAQSPVYSPPSLPEGTDSQSPVQRPQSPPEGEDSLS
PLYIPQ---CPPEGEDSLSSLQYPHSPP-------------------------------S
-T--PEWEVSLSPLRFP---HSPPQG-E----------------DSQSSLQSPVI-TCS-
-------------SS---------------TSLS-----------------LPQ------
---DFPERPQRP-----------------------------------PEGPAQSP--LQR
P-----------------------------LSSF-FYTLASLLQSPH----------GSP
Q--------------------------------------------SRPEGPDQSPLQRPV
SSFSSTSL-SLS----QSS--PRPV---------------SSSSSSTSLSLSQSSP----
----ESPQSPP--------------------------------------EGPA---QSPL
QSAVSSSS--------S-------------------------------------------
----------------------STLESESLTDRESFMESEPLFTYTLDEKVDELV-----
-------RFLLLRYQAKQPVT-KAEMV--TNVINRYT-----GYFPMIFRKAREF-----
----IEILFGIS---------LRE-VDPE----------DSYV-----------------
-------F----------------------------------VNTLAL-SCE----GS--
VS-DE-QGMPQNHLL-------FLVLSIIFMKGTC------ASEE---VIWDVLSGI---
-----GVR-AGR----EHFIFGEPRELLTKVWVQE------HYLEYREV-PNTAPPRYEF
----LWGPRAHSEIS--KRKVVEFLAMLNNTVPI----S-FPPSYKD---ALKDVEERAQ
ALIDTTDDS-T-------------------------------------------------
------------------------------------------------------------
-----------------------AT------DSA----------------SSS--V----
------------------------------------------------------------
---------VSP---------------------SFSS-----------------------
------------------E-----------------------------------------
------------------------------------------------------------
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-------------------------------------------------SKHLNGEERG-
GSNYRWIPWGWRPP--LLDVAIL---QERANKLVK------YLLVKD-QTQIPI--KR--
------------------------------------------------------------
----SDM---LKVVIQGYDEYFPEIIET-SYTLEKMFRVNLNEIDKQSSLYI-LISTQES
STG-IL-GTTKDT-PKLG---LLM----------VILSV----------IL--------M
-NGNK----A-N--EAVIWEVLHKLGLC--PGVRHSLFGEVRKLITDEFVKQK-------
---------YLEYKRVSNSRP---P--EYEFFWGLHSYHETSKMKVLKFACKVQKK---D
------PKDWAAQYREAVEMEVQAAAVAAA--EAEAR----VEARAQMGIGEEAV-----
------AGP--WNWDDMDIDCLT-REELGDDAQVWS-RISF----EIEARAQEKADASTN
IDFSRGASVGASFHDCASISFSDVPSP--SGGFSG-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------RAGISFGGTLSTNASFSSTASISFSGTPSTCSSFSGG-----------
-----------------------------------------------------------A
SLSFGGTSSTSSSFSSEASISFGGALCTSASFGGGVSSCFSGPLI--TSTSFSSGASSGF
GG------------------TL-STTADFSGMLIASTSFGSAHGTSAVFSGALSTSTGFG
GTLSTSVCFGGSPSSSASFGGTLNTNICFSGSPSTSTGFDS----ILSTSVSFGGNSSTT
ADFGGTLSTSVYFGGSLGTN-ASFGAL-STSVG---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------FSGALNTSAGFISAVSTSAGFIGVPPINSGFGSVFSTS
ADFSGALSTATDFGSAP----------------------------------------STS
IGFGGAPSTSLCFGNVSNTNLCFGGPPSTSNCFSGTTSASFGNGPNISVGFSFGNGLSTS
TGFSGGLSTSAGF-----------------------------------------------
---------------------------------GGGLGTSADFGGGLISSNGFGGGLGTN
DGISSTLGTSAGFSGRLSISDGFGGGPNTNFDGGLSAIIGFGSGFNTSIGFTGEPSTSTD
FNWGPSSIIGFSGGLCTSAGFSGGLSSGTGFGGGP-------------------------
------------------------------------------------------------
----------SSGAGFGGG-PSNGAGVGGGATSLGACSFYG-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------MPRGQK---SKLRAREKRRRQA
-PE-----KPQDL-----------------------------------------------
-VS-------------AQATTAVG------------------------------------
-----------------------------------------------------------E
-VFP-------------------------SLCCP-----H---------------FNSSP
TAGS-----------------------------YR-------A-------PQERQR---A
T--ATTTTPV-A------------------------------------------------
------------------------------------------------------------
-----------------LS----YTKSNEAA---------------NN-R-GE-ERP---
-----------------------------RS-SQVQPTALPFQRDLLDEKVVLLV-----
-------HYLLRKYQKKELIT-KAGML--RNVIQMYR-----NQFHETLKRASDH-----
----LELVFGLD---------LKE-ADPNR---------HIYV-----------------
-------L----------------------------------VNKLEP-SYD----AVLS
----DHGGVPKTGLL-------MTILGVIFTNRNR------AMEE---QVWQTLNVM---
-----GLY-EGR----QHFIFGEPRKLITKDFVKD------KYLEYRQV-SNSDPPRYEF
----LWGPRAHAETS--KMRVLEFLAKVHDTVPS----A-FPAWYEE---ALRDEEERAR
AR-AAARAHTA-AM----------------------------------------------
----------------------------------------------------------AS
--------------------ARA--R-----------------------ALTS-AHSKAT
TSA---------------RSR-AKT----------SVCTKAMPA-A-------------P
---------PTPN---K-----------------V-------------------------
------------------------------------------------------------
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--------------------------------------MPLEQ-----------------
-----------------RSQ-HYKPE-E----------------RLEA----RGE-ALG-
-------------LVGAQASATEE------------------------------------
-----------------------------------------------------------Q
E-T---------------------------------------------------------
------------------------------------------------------------
----PSSSSTVV----EVT--RGE------------------------------------
---------VP--------------------------------------AAES---LGPP
QSPPPFPL---PSATLS-G--A--------------------------------------
---------------------------------------------------NLMR-----
-------TPATKKRRAREPVT-KAEML--ESVMRNCQ-----FFFPVIFSKASDS-----
----LQLVFGIE---------LME-VDPIG---------HLYI-----------------
-------F----------------------------------VTCLGL-SYD----GLLG
---DN-QIMPKTGLL-------IILLA-ITKEGDC------APEE---KIWEELSVL---
-----EVF-EGR----EHSIFTDPRKLLTQDFVQE------NYLEYWQM-PSSDPACYEF
----LWGPRALVETS--HVKVLYHMLKISGGPHF----S-YSPLHEW---ALRDGEE---
------------------------------------------------------------
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------------------------------------------

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------------------------------------------------------------
-----------------------GAFALE---------------------RTVED-----
GSDPTEGTTPWRQREESRVL----------------PG-------V----------KPL-
-------------------GPVTLPRLL---SAPTPVIMSLVQ-----------------
-----------------MSE-LRQAV-E--------------------------------
------------------------------------------------------------
-------------------------------------------------------D----
LQDP--------------------------------------------------------
RDAQGL---------------------------------------VDVQQLEAEQEGAAS
------------------------------------------------------------
--------------------------------------------------------PGTP
APPQSP------------------------------------------------------
---------------------SYSA------------GAESLRQGAELSMMADLV-----
-------SFLLLKYHRKQPTT-RAEML--S-ILREYQ-----DHFPAVFSQASEC-----
----MQLVFGVD---------VKE-VDPKE---------HLYI-----------------
-------L----------------------------------VPTLGL-TCD----GM--
QG-GE-QSMPKNGLL-------VILLGVIVLGGGG------VPEE---EVWGALGVM---
-----GVY-PGR----EHFIYGEPRELITKAWVQE------GYLEYRQV-ANSDPARHEF
----LWGPRAHAETS--KLQVLEHLFRLNSEGPI----S-FPSLSEE---AVSNEEEGA-
------------------------------------------------------------
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--------------------------------------------------------MAE-
----------------------------------------------------------GS
YH-----K-E-------SEGYNVEDMDEGSDEVG--EEDMVEGNDYE----EFGAFGGYG
ALTSFDIRI--LRAFGSLG-----------------------------PGFRILANEPWE
LENP-MLARTLL-------EAFR--MDPETLANEPAARAA-------------NVARAAS
---S----------NQA-ARAA--------------------AAAARATYHQV---VANH
-------------------------------------------------SVAT-------
------DQGSGGDTQPMTSAAE--AQ--------------------AATLETSLASPHSS
------QMLVKSEMATPGAPAR-STQPQTSS---------------RAQ-----------
-------------EAA----------------AEGPSTACAFSQAPRASEMD-ATRPKTA
FLGQ----------------------------NDVFD-------FTQPAGV---------
----SGMAFPRPKRPAPAQEA--ATEGPSA---------AS-GGPQAASAGEGAATRPKT
T-----------------------------K-----------------------------
------------------------------------------------------------
--------------------------------------------------------SGKA
LAKTRWVEPQNVVAAA--------AAKA-KMATS---------IPEPEGAAA---TSQQS
AE-----------------------P---------------------------------W
TRMGGKRTKKSKHLDDEY--------ESSE-EEREPPAVPPTWRASQPPLTT--------
---------V----R---------------------------------------------
----------------------------------------PQMA----------------
-----------------PRPP-----------------------------M----A----
-LRSQVPSRHVLCLP-PRNVTLL---QERANKLVK------YLMIKD-YKKIPI--KR--
------------------------------------------------------------
----SDM---LKDVIREYDEHFPEIIERATYTLEKKFGIHLKEIDKEEHLYI-LVCTRDS
SAR-LL-GKTKDT-PRLS---LLL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPFLGDLRKLITEDFVKQK-------
---------YLEYKKIPNSSP---P--EYEFLWGLRARHETSKMRVLRFIAQYQNR---D
------PREWRAHFLEAVDDAFKTMDVDMA--EEHAR----AQMRAQMNIGEEAL-----
------IGR--WSWDDIQVELLT-WDEDGDFGDAWS-RIPF----AFWARYHQYILNSNR
ANRRG------SWRAGVSSGTNGAASTSMLDGPSTS-ST---IRTRNAARTS--------
----ASFFSWIQQR----------------------------------------------
------------------------------------------------------------
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------------------------------------------

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------------------MSQ--LSKNLGDSSPPAEAPKPP-------------------
----------VYSRPTVLMRAP-----PASSRAPPVPWDPPPIDLQA-SLAAWQAPQPAW
EAPQGQPPTPV---APMAQPPALGGPMVQAPPLGGPMGKPPT------------------
---------------PGVLMIHP-PPPGAPIAQPPTPGVLMMHPSAPGAPMAHPPP-PGT
PMAHPP-------------------------PPGTPLAH---------------------
-----P---------P------------------PPG---------------------TP
------------------------MAHP--PPPGTPMVHPPPPGTPMAHPPPPGTPMAHP
PPPGTP--MA-------------------HPPPPGTPMAQP---PTPGVLMAQPLTPGVL
MVQPP-------------APGAPMAQPP---PPGALM-------------------TQPP
PPGAPMAKPPGPGVLMIHPPGSRAPITQPAASG---------------APMAQPAA----
---PPAQPLASWAPQAQPLILQIQSQVI----R-------APPQV---P-----------
-------Q---GPQAPPAQLATPPGWQATSPGWQAPPQGWQATPLAWQATQVTWQAPT--
----------IAWQAPPPV-RQGPPPIRP-------------GPPPIRPGPPPVR---QA
PPP---------------------------------------------------------
------------------------------------------------------------
--------IRQAPPLIRQAPP-PI------------------------------------
-----------------------------------------------------------R
--------------PAPQVLATPPPLWQALPPPP-----P---------------LRQAP
QARLPTPQVRAAPQVR------AAPQVPTAPAATQ-------VPTAPPAGPQAPQA---V
L--S----AP----------------------------------------LSA-------
----------P-----------QAVH--CPPIIWQAPKGQAPVPHE--------------
------------------------------------------------------------
------------------------------------------------------------
---------LPTSMEFQEVQQ-AQ-AL--AWQASKAP-----GQFWQPVPTQEAQRQ---
----GPPVVQLE-------QPFQGVPASQKALQIQL-PTQQAQPT--GPQAELPTLQLQP
SWQGPPAALQGQPGAPLAAANFPMGSAKSLMTP-SGESRASSIERRTSS-KE----RRTS
SK--ERRAPSKDRM----------IFAATFCAPKA----VSAARAHLPTAWKNLPATSET
FTATSRVF-PTT----SRFQPASSNAFQGPSAPSE----TPKSLPLAL---QDPFACMEA
LPAVPWVPQPSVNASKASQAVPTILM-AKAAAPK----A-MATT-QE---ASKTPAEPPR
RS-----------------------GKA--------------------------------
--TRK-----KKHLNTEE-DSSGQMLP-------------------------------LR
--D-WQAP----RPWENLN--LNDW--EVENSIQ-V--LGDWEGPSTSRGLSGWEGPSTS
-RI---------------LSG---WEGPSTTWALSAWEGPSTSR-A--------------
---------LGLW---------------ESPGSPQPLIISEFT-------------N---
LSQGFGVTQNDPKLE-TQPLSPL---DERANALVQ------FLLVKD-QAKVPI--KR--
------------------------------------------------------------
----SEM---VKFIIREYKDECLDIINRANNKLECVFGYQLKEIDPENHSYI-IINKLGH
HRGEPV-ASYLDR-PKLG---LLM----------VVLSL----------IF--------M
-KGNC----V-R--EDMIFSFLYRLGLD--VRETHALFGNTKKLITEVFVRQK-------
---------YLEYRRIPYTEP---A--EYEFLWGPRAFLETSKMLVLRFLAKLHKR---D
------PRCWPLQYFEALAECEAEDLDEDE-PGS----GDNA-------GDP--------
---TSSSPPR--------------------------------------------------
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--------------------------------------MPRGQK---SKLRAREKR-QQT
-RA-----QNQAF-----------------------------------------------
-SV-------------PQAIPEEE------------------------------------
-----------------------------------------------------------E
-EEFSLFSPPFH------------------CTSV-----F---------------S-GDT
PGSL-D-------------------------VYM----------------SQASGE---G
P--GPSYLQG-A------------------------------------------------
------------------------------------------------------------
-----------------TA----ATKSDEES---------------ES-Q-DE-AIV---
-----------------------------SS-SQASLFTLRPARDPLTRKAGRLV-----
-------QFLLEKYKKGEPIL-KTDML--KVLHKRYK-----DHFPEILRRASER-----
----MEVVFGLE---------LKV-VDRVN---------VSYT-----------------
-------L----------------------------------VSKLAF-SGE---EGT-S
----GDNGLPKSGLL-------MMLLGVIFVKGNR------ATEE---QVWEFLDVL---
-----GLH-PGR----KHLIYGEPRKLITKDMVEQ------NYLEYRQV-PNSDPPTYEF
----LWGPRAYAETT--KMKVLEILAKINDTVPT----A-FPNLYDE---AVRDEEERGV
GR-RARR-----------------------------------------------------
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--------------------------------------MFHF-P----------------
-----------------KHP-HNMFE-Q----------------ECQA----QIE-TQE-
-------------LVEAQVPTTEE------------------------------------
-----------------------------------------------------------D
E--------------------------SSSPTSSFHF--FLPSS----------------
-----------------------------------------------------------S
--SPSCPSSPLI----PDT--PEEVKV---------------------------------
------PAAVI--------------------------------------PSTS-------
QNPQTTSS---HSSSSFST--TLSRTSDE----------------NSSSE-EQDKST---
------------S------TSQDPA------------GAVSLPRDPLGKKVNDLV-----
-------KFLLLKYRLKLPVT-KEEML--KVVDKKNK-----SQFPVIFQKACKC-----
----MEVICGID---------MKE-VDPTI---------QSYI-----------------
-------L----------------------------------VNSLDL-AYD----ENLS
---DD-QGMPKKGLL-------IIILGVIFIEGNC------VPEE---EIWDLLNMM---
-----GVH-TGR----DHFIFGEPRKLITRDWVQE------KYLTYRQV-PDSDPACYEF
----LWGPRAHMETS--KMKVLEFFAKVNGTYPS----S-FSTQYEE---ALRDEEERTK
SRIAPADSTAS-------------------------------------------------
------------------------------------------------------------
-----------------------TF--------L----------------APCW---PK-
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---------ASP---------------------GMSE-----------------------
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--------------------------------------------------------MAE-
----------------------------------------------------------GS
YS-----V-Q-------SANSSVEDMDEGSHQVR--EEEMVGGNDYE----EFGAFGGYG
TLTSFDIHL--LRAFDTLG-----------------------------SGFHILSNEPWE
LENP-VLAQTLV-------EALQ--LDPDTLANETEARAA-------------NVARSAA
---S----------NRA-ARAA--------------------ATAARRSFTQV---VANH
L-------------------------------------------------IPP-------
------LPATGDSAQPMTYAE---AQ--------------------GATPEAILASPQTS
------QVSVASEMAAPGAPTI-STQSQTAT---------------PDHQ-AA-------
--------AEGPGTAC----------------AEGPGTACAFCPAPSASETD-ATRPQAA
FLGQ----------------------------NDVFD-------FTQPAGV---------
----SGTAFTRPKRPAPAQEA--ATEAPSA---------AS-GMSQAVPAKEVAATRPKT
T-----------------------------K-----------------------------
------------------------------------------------------------
--------------------------------------------------------SGKA
VAKTRWVEPPNVGATA--------AANT-KMATS---------IPEPEGAAA---TAQHS
GE-----------------------P---------------------------------W
ARMGGKRTKKSKHLDDEY--------ESSE-EEREPPAVPATWRTSQQPPVT--------
---------A----R---------------------------------------------
----------------------------------------AQVA----------------
-----------------PRPP-----------------------------M----P----
-LRSQIPSRHVLCLP-PRNVTLL---QERANKLVK------YLMIKD-YKKIPI--KR--
------------------------------------------------------------
----SDM---VKDVIREYDEHFPEIIERATYTLEKKFGIHLKEIDKEEHLYI-LVCTRDS
SAR-LL-GKTKDT-PRLS---LLL----------VILGI----------VF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPFLGDLRKLITDDFVKQK-------
---------YLEYKKIPSSNP---P--EYEFLWGLRACHETSKMRVLRFIAQNQNR---D
------PREWKAHFLEAVDDAFKTMDMDMA--EEHAR----AQMRAQMNIGDEAL-----
------IGR--WSWDDIQAELLT-WDEDGDFGDAWA-RIPF----AFWARYHQYILNSSR
TNRRA------TWRAGVSSGTNPGASTSILDGPSTS-ST---IRTRNAARAG--------
----ASFFSWIQQR----------------------------------------------
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--------------------------------------MPRGQK---SKLRAREKR-RQA
-RE-----ESWNP-----------------------------------------------
-LD-------------AQATVSEE------------------------------------
-----------------------------------------------------------E
EESS-------------------------SSPSL-----D---------------VKDDP
RSSP-A------------------------SGTPS-------G-------PQVLGE---V
H--STTASAE-A------------------------------------------------
------------------------------------------------------------
-----------------AS----STRFAEGA---------------SD-Q-LE-ETL---
-----------------------------NA-LHANDIAEYWYRGPLDEKVVMLV-----
-------HYLLYKYQRKEPIT-KVDML--RNVIQVYK-----HNFHEIFKRASEH-----
----LELVFGLD---------MKE-MDPNR---------NTYV-----------------
-------L----------------------------------INKLEL-SCD----SR--
----EHRGVPKTGVL-------MTILGVIFMKGNC------ATEE---DVWKVLNMM---
-----GLH-DGR----NHFIFGDPKKLITEDLVKD------DYLVYRQV-PDRDPPCYEF
----LWGPRAYSETT--KMKVLEFVAKVNHTSPS----A-FSPYYEE---ALRDEKERAQ
AR-STARAQIA-AI----------------------------------------------
----------------------------------------------------------AS
--------------------ARS--K-----------------------AMAN-SLSLPK
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--------------------------------------MLHGQ-----------------
-----------------KGQ-QSTSP-D----------------GLVP----KD--IQG-
-------------LVD--------------------------------------------
---------------------------------------------------TDVP-----
--A---------------------------------------------------------
---------------------------------------------------------ARV
RKTISCSFCLLT----PDV-----S-----------------------------------
---------------------------------------------------------KAP
RSR--ARS----STASA-A--APSSKPLK----------------GPKRK-KTEA-P---
------------G------TS---------------------RASTIEKKVTDLV-----
-------VFLTHTYMTKKSTT-TEEML--KMVIKEDK-----DYFPVIFKKACES-----
----MEVVFGIE---------VKN-VNPTD---------GSYV-----------------
-------L----------------------------------TKMLDL-TYD----GMLR
---DQ-EGVPKTGLL-------ILILGVIFVEGNC------VPEK---KVWEVLSRL---
-----GMR-PGT----RDFLYGEPRQLITQDFVKE------GYLEYRQV-SDSNPTSYEV
----LWGPRAYVETS--KMQVLKCFAKVNGMDVS----D-FPTWYEE---ALRDEEERAR
GRNAATGG----------------------------------------------------
------------------------------------------------------------
-----------------------IV------IMD----------------SGS--R--A-
------------------------------------------------------------
---------FSV---------------------TFSH-----------------------
------------------SEE---------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
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--------------------------------------------------------MAE-
----------------------------------------------------------GS
YR-----K-E-------SEGYNVEDMDEGSDEVG--EEDMVEGNDYE----EFGAFGGYG
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---S----------NQA-ARAA--------------------ATAARATYNQV---VTNH
H------------------------------------------------PVAT-------
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T-----------------------------K-----------------------------
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SAR-LL-GKTKDT-PRLS---LLL----------VILGV----------IF--------M
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------PREWRAHFLEAVDDAFKTMDVDMA--EEHAR----AQMRAQMNIGEEAL-----
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ANRRG------TWRAGVSSGTNGAASASMLDGPSTS-ST---IRTRNAARTS--------
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AQ-PRVAARRG-TTAM--------------------------------------------
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---------------------------------------MSER-----------------
---------------RE-SGT----------------------------GSTHFQAEASE
KVTD-LRMQSQL-------TVNQ--NLEASKTPKAS------------------KT----
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--------PKISETKKVS-------NTTEVS---------------KVT-----------
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PIAFWARRAS----RTRLA----S------------------------------------
------------------------------------WARRALL----SLRSPKARRGKAR
RRA---------------------------------------------------------
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TDAGIL-GTTKDS-PKLG---LLM----------VLLSI----------IF--------M
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---------YLDYARVPNSNP---P--EYEFFWGLRSYYETSKMKVLKFACKVQKK---D
------PKEWAAQYREAMEADMKAAAEAAA--DAKAR----AEIRAQMGIGLGSE-----
----NAAGP--CNWD-------------EADIGPWA-KARIQAGAETKAKAQESG--GAS
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VSLQTF---------------------------------------KEPQSVEVEQASRDV
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----MEMLFGLE---------VKE-VDSIN---------HCYG-----------------
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QN-DE-YSFPKTGLL-------ILILGVIYMKGNR------ATEE---EMWEALNLM---
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E-----------------------------------------------------------
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--------------------------------------------------------MAE-
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FS-----V-Q-------SENYSVEDMDEGSDEVG--EEEMVEGNDYE----EFGAFGGYG
TLTSFDIHI--LRAFGSLG-----------------------------PGLRILSNEPWE
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R-------------------------------------------------VAT-------
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T-----------------------------K-----------------------------
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LAKTRWVEPQNVVAAA--------AAKA-KMATS---------IPEPEGAAA--ATAQHS
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------PREWKAHFLEAVDDAFKTMDVDMA--EEHAR----AQMRAQMNIGDEAL-----
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PMSHPP-------------------------PPGTPMAH---------------------
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PPPGTP--MA-------------------HPPPPGTPLAQP---PAPGVLMAQPLTPGVL
MVQPP-------------APGTPMAQPP---PPAALM-------------------TQPP
PSATPMAKPPGPGVVMIHPPG-RAPIIQPPVSG---------------APMAQPVPP---
----PSQPVATWAPQGQPLILQIQSQVI----R-------APPQV---P-----------
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---------LPTSMEYQEVQQ-AQ-AL--AWQAPKAP-----THFWQPLPAQEAQGQ---
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SWQGPPPILQAQPGAPVGGENFPRGSDKSLMTP-SGESRASSIEPRGSS-KD----RRTS
SK--EKRAPSKDRM----------IFGGTFCAPRA----VSATRAHLPTAWKNLPATSET
FTATSRVF-PST----SHFQPASSNAFKGPSATSE----SPRSLPFAL---QDPYACTEA
LPAVPWVPQPDVNASQASKAVPTILM-ATAAAPQ----A-AATV-QE---ASK-TVEPPR
RS-----------------------GKA--------------------------------
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--D-WQGP----RAWENPS--LYDW--EVPSSVQ-V--LGDWECPNTPRGMNGWECPSTS
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------------------------------------------------------------
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FQGGFF-ASYLDR-PKFG---LLM----------VVLSL----------IF--------M
-KGNC----I-R--ENLIFSFLFKLGFD--VLGTHGLLGDLKQLITEVFVRHK-------
---------YLEYRRIPCTEP---A--EYEFLWGPRAFLETSKMLVLRFLAKLHKK---D
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---VGT---EAQPVVKAVILYCLPSCPHSCLLPPTRVVI---------------------
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T-----------------------------------------------------------
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PPPGTP--MA-------------------HPPPPGTPMAQP---PTPGVLMAQPLTPGVL
MVQPP-------------APGAPMAQPP---PPGALM-------------------TQPP
PPGAPMAKPPGPGVLMIHPPGSRAPITQAPASG---------------APMAQPAA----
---PPAQPLASWAPQAQPLILQIQSQVI----R-------APPQV---P-----------
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PPP---------------------------------------------------------
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---------LPTSMEFQEVQQ-AQ-AL--AWQAPKAP-----GQFWQPVPTQEAQRQ---
----GPPLVQLE-------QPFQGVPASQKALQIQL-PTQQAQPS--GPQAELPTLQLQP
SWQGSPTALQGQPGAPIAAANFPVGSAKSLMTP-SGESRASSIERRTSS-KE----RRTS
SK--ERRAPSKDRM----------IFAATFCAPKA----VSAARAHLPTAWKNLPATSET
FTATSRVF-PTT----SRFQPASSNAFQGPSAPSE----TPKSLPLAL---QDPFACMEA
LPAAPWVPQPSVNASKAAQAVPTILM-ATAAAPK----A-MATT-QE---ASKTSAEPPR
RS-----------------------GKA--------------------------------
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--D-WQAP----RPWENLN--LNDW--EVENPIQ-V--LGDWEGPSTSRGLSGWEGPSTS
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HKGEPV-ASYLDR-PKLG---LLM----------VVLSL----------IF--------M
-KGNC----V-R--EDMIFSFLYRLGLD--VRETHALFGNTKKLITEVFVRQK-------
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S--PPASQAAI----------LAGPETPPLGP------------T---------------
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TDAGIL-GTTKES-PKLG---LLM----------VLLSI----------IF--------M
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------PKEWAAQYREAMEADLKAAAEAAA--EAKAR----AEIRAQMGIGLGSE-----
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----------------GAA----GAKSNEGA---------------KS-I-GNKSAH---
--------------------------------PSGKGAFQTGGADPISRKAGMLI-----
-------NYLLEKYKMQELIL-KEDML--KIVKRKYS-----GHFSEILRRASER-----
----MELVFGLY---------LKE-VKPGG---------HSFS-----------------
-------L----------------------------------VSEPDF-SSD----GYHS
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ASRS-FPL----------------------------------------------------
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--------------------------------------MPRGQK---SKLRAREKR-RQA
-HG-----ETPGL-----------------------------------------------
-QA-------------AQAPAAEE------------------------------------
-----------------------------------------------------------E
-ASTPPSSPPSGGTPQSSPVAGRPPSPTTPPSSP-----P---------------SGGTP
QSSP-A-------------------------AGR----------------PQGPRR---S
P--SPTTPTK-A------------------------------------------------
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----MELVFGLE---------LKE-VDPSG---------QSYS-----------------
-------L----------------------------------VSKLDL-TTE---GSL-G
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---------------------M-------IRGQ-----VRQVRT---LSEN------RQA
-HR-----ETQGL-----------------------------------------------
-AG-------------AQVTQAEN------------------------------------
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-ASY-------------------------SSSSS-----L---------------IPHPM
EDVS-I------------------------SGTPS-------S-------SQCPQS---A
S--FSSTVTT-G------------------------------------------------
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-----------------TS----LSRSTEGS---------------SI-Q-EEMEKS---
-----------------------------DG-GSTSQDLENLHIDLLDEKVELLI-----
-------NFLLQKYQMREPVT-KADMI--GNVVKEYK-----DDFLEILRSASER-----
----MELVFGLD---------VKE-VDPIN---------HSYT-----------------
-------L----------------------------------ANKLDL-TYN----GMLS
----DQQGMPKTGLL-------IIILGVIFMKGNC------ATEE---EVWKVLNMM---
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--------------------------------------MNPAE-----------------
-----------------NSRN-VN-Q-D----------------STRS----ERE-TRD-
-------------LEAGEEE----------------------------------------
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----------TT----SG------------------------------------------
---------------------------------------------------DV---LGSS
QGAQRA--------SLS-S--SAGV------------------------P-SVEASS---
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----LRLTFGLE---------IIE-RNPRV---------HSYS-----------------
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LH-GF-RGVPKIGLV-------IVVLCIIFIQDNC------ASEQ---ELWRILNNM---
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--------------------------------------MPRGQK---SKLRAREKR-RRA
Q-S-----KAQGL-----------------------------------------------
-G--------------AQAASAGE------------------------------------
-----------------------------------------------------------G
-ESP-------------------------SS-SP-----G---------------SGGAS
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A--AA-SS-AAA------------------------------------------------
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-----------------IS----CASSGESA---------------MS-Q-AE-GSP---
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----MELVFGLD---------LKE-VDPSN---------HLYV-----------------
-------L----------------------------------FSQLDL-PDE---ENT-S
----EGMSFPKNGLL-------MPLLGVIFLNGNR------ATEE---EMWEFLNVL---
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----LWGPRAYAETT--KMKVLEFWAKANDTVPS----A-FQARYEE---AMRDEEERAL
AR-ATARALSR-AMSR--------------------------------------------
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------------------MSQ--LSKNLGDSSPPAEAPKPP-------------------
----------VYSRPTVLMRAP-----PASSRAPPVPWDPPPTDLQA-SLAAWQAPQPAW
EAPQGQLPAPV---VPMTQPPALGGPIVPAPPLGGPMGKPPT------------------
---------------PGVLMVHP-PPPGAPMAQPPTPGVLMVHPSAPGAPMAHPPP-PGT
PMSHPP-------------------------PPGTPMAH---------------------
-----P---------P------------------PPGTP-MA----------HPPPPGTP
------------------------MVHP--PPPGTPMAHPPPPGTPMAHPPPPGTPMAHP
PPPGTP--MA-------------------HPPPPGTPMAQP---PAPGVLMAQPLTPGVL
MVQPA-------------APGAPMVQPP----PAAVM-------------------TQPQ
PSGAPMAKPPGPGVLMIHPPGARAPMTQPPASG---------------APMAQPAAPPAQ
PMAPPAQPMASWAPQAQPLILQIQSQVI----R-------APPQV---P-----------
-------Q---GPQAPPAQLATPPGWQATSPGWQAAQQGWQATPLTWQTTQVTWQAPA--
----------VTWQVPPPM-RQGPPPIRP-------------GPPPIRPGPPPVR---QA
PPLIRQ---APPVIRQAPP-VIRQAPPVIRQAPP-------VIRQAPPVIRQAPPVIRQA
-PP---------V-----------------------------------------------
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---------IPTSMEFQEVQQ-TQ-AL--AWQAQKAP-----THIWQPLPAQEAQRQ---
----APPLVQLE-------QPFQGAPPSQKAVQIQL-HPQQAQAS--GPQAEVPTLPLQP
SWQAPPAVLQAQPGPPVAAANFPLGSAKSLMTP-SGECRASSIDRRGSS-KE----RRTS
SK--ERRAPSKDRM----------IFAATFCAPKA----VSAARAHLPAAWKNLPATPET
FAPSSSVF-PAT----SQFQPASLNAFKGPSAASE----TPKSLPYAL---QDPFACVEA
LPAVPWVPQPNMNASKASQAVPTFLM-ATAAAPQ----A-TATT-QE---ASKTSVEPPR
RS-----------------------GKA--------------------------------
--TRK-----KKHLEAQE-DIRGHTRA-------------------------------FH
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-RI---------------LSG---WEGPSASWALSAWEGPSTSR-A--------------
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VPPGSSATQDNSKVE-AQPLSPL---DERANALVQ------FLLVKD-QAKVPV--QR--
------------------------------------------------------------
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HTGNLV-ASYLDR-PKFG---LLM----------VVLSL----------IF--------M
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------PQSWPFHYLEALAECEWEDTDEDE-PDT--GD--SA-------HGP--------
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------------------MSQ--LSKNLGDSSPPAEAPKPP-------------------
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EAPQGQLPAPV---APLAQPPALGG-LVQAPPPGGPMGKPPT------------------
---------------PGVLMLQPPPPPGAPMPQPPTPGALMVHPSASGNPIAHPPP-PGT
PMSHPP-------------------------PPGTPMAH---------------------
-----P---------P------------------PPGTPM----A-------HPPPPGTP
------------------------MAHP--PPPGTPMAHPPPPGTPMVHPPPPGTPMAHP
PTPGTP--MA-------------------HPPPPGTPMAQP---PAPGVLMAQPLTPGVL
MVRPPPAPPAPPAPPAPPAPPAPMVQPL---PPAALM-------------------TQPP
PSAVPMPKPPAPGVLMMHPSCSGVPITHPPVSG---------------APMAQPVAP---
----PAQPMASWAPQGQPLILQIQSQVL----R-------APPQV---P-----------
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------------------------------------------------------------
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---------LPTSMEFQEVQQ-SQ-AL--AWQAPKVP-----THTWQPLPAQEAQGQ---
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CWQGPPPILQAQPGAPLGGANFPRGQARSHMIP-SGECRAFSSEPKRSS-KE----RRTS
TK--EKKGPSKDRV----------IFAGTFCAPRA----MSASRAYLPNAWKNLPATSDT
FSATSRVF-PST----SHFQPASSHAFKGPSAISE----SPKSLPLVP---QDPYACAEA
LPAVPWVPQPNANVSKSSKAVPHILM-ATAAPPQ----A-TATA-PG---ASSV-VDPPR
RS-----------------------GKV--------------------------------
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T-----------------------------------------------------------
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PQNLE--------------------S---------------------------------R
TIIRGKRTRKINNLNV---------EESSSGDQRRAPLAPGTWRSAPVPVTT-QSPPGAP
PNVLWQTPLA----WQNPS----GWQNQPTRQTP----P-ARQSPPARQTPPAWQNPVAW
QNPVIWPNPVIWQNPVIWPNPI-VWPGPVVWPNPLAWQNPPGWQTPPGWQTPPGWQGPPD
WQG---PPDWPLPPDW-PLPP-DWPLP-TDWPLPPDWIPTDWPVPPDWQNLRPSPNLRP-
-SPNSRASQNLGASQ-PRDVALL---QERANKLVK------YLMLKD-YTKVPI--KR--
------------------------------------------------------------
----SEM---LRDIIREYTDVYPEIIERACFVLEKKFGIQLKEIDKEEHLYI-LISTPE-
SLAGIL-GTTKDT-PKLG---LLL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGYDWALSSLA----CYMILWQ--------
------------QRMVPGLHQ---PGSLRELVWGGTEPKN--------------------
------------------------------------------------------------
-----------VTWVDGEIVLVS-ASLISDFCAGKL-RIRF----FFWNSLAFSMIQVML
AV----------------------------------------------------------
------------------------------------------------------------
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--------------------------------------MPRSQK---SKLRYRE-KCRQA
-RE-----ETQGP-----------------------------------------------
-HG-------------AQASVEVK------------------------------------
-----------------------------------------------------------E
-EAP-------------------------SSPSA-----V---------------SGGSP
QSSP-A-------------------------AGH----------------PEEPPR---S
L--SPLTLAAAV----SGPRAEEEAE----RP-------------SSPEAPGSPQS-PGS
PEAPGSPQSP----------------------------GVPQ--SPGSPEALG-------
-SPEAP---GSPE----------APSSPEAT---------------GSPE-APGSP----
----------------EGPSFPEAPGS--PEAPGTWGATRHSRRDPLSRKAALVL-----
-------QFLLNKYKLKQPIL-KADML--KLIRRKYK-----EQFPEILRMCSER-----
----LELVFGLD---------LKE-HDASA---------QSYL-----------------
-------L----------------------------------VSKLDPSETN------LS
----GGWGLPRNGLL-------LPLLGVIFLNGNC------APEE---EIWQFLSLL---
-----GVY-KGR----RHFIFGDPWKLITRDLVRE------KYVEYR-------------
------------------------------------------------------------
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--------------------------------------MPRGQK---SKLRAREKR-RQA
-RA-----ETQGL-----------------------------------------------
-ED-------------AQATAAA-------------------------------------
-----------------------------------------------------------A
GESL-------------------------SLVHA-----L---------------TEDRP
QNLS-A------------------------AETPS-------T-------PEAPQG----
----TTDASA-A------------------------------------------------
------------------------------------------------------------
-----------------VS----CTNSDEGT---------------SS-Q-KE-ESS---
------------------------------K-S--SRGTEGSRRDPLNKKVVLLV-----
-------QFLLQKYQKKEPIT-KADML--KFVIKKYK-----YHFNEILKRASEH-----
----MELAFGVD---------LKE-VDPTR---------HCYA-----------------
-------L----------------------------------VSKLDL-TFD----GTMN
----EEENMPKTGLL-------MIVLGVIFMNGKC------APEE---EIWEVLNMM---
-----GVY-AER----KHFLYGDPKKVITEDLVQL------KYLEYRQV-PDSDPPRYEF
----LWGPRAHAETS--KMKVLEFLAKVHDTVPS----A-FPSWYEE---ALRDEEERAQ
AR-AAARARLA-AM----------------------------------------------
----------------------------------------------------------AS
--------------------VRS--R-----------------------ATAS-NLSHAK
------------------------------------------------------------
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--------------------------------------MENPD-----------------
-----------------NTH-YCNFQ-G----------------SARS----QRE-----
-------------LDNAQAT----------------------------------------
------------------------------------------------------------
--------------------------------------MAVV------------------
------------------------------------------------------------
---DEEE-ATPT----SKK--V--------------------------------------
----------Y--------------------------------------GSGI---RSPP
QSPQKASS---PLVILA-S--VPEG------------------------P-SEEASS---
------------N------QVEEWE------------DPLYILYNAHNIKVYELA-----
-------NFLLFNYQMKAFTT-KAEML--ESIGREYE-----EYYPLIFSEASES-----
----LKLVSDID---------MIE-VDPFV---------QSYI-----------------
-------L----------------------------------VTALGL-TYD----GM--
LT-DV-QGKPKTGNL-------IVVLGAIFMQGNC------VSEE---IIWKMLNNI---
-----ELC-GGR----HLYIHQDPRKLISEEFVQE------GYLEYRQV-PNSDPPSYEF
----LWGPRAFAETT--KMKVLEVFASITMTDPR----A-YTEKYAE---ALRDETERAQ
ARIIQQIVLQL-------------------------------------------------
------------------------------------------------------------
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--------------------------------------MPRSHK---SKLHAGEKR-LKA
-RR-----ETQSC-----------------------------------------------
-GG-------------AQVTAAAE------------------------------------
-----------------------------------------------------------E
-ESA-------------------------TSSSP-----Q---------------CGGIT
QSLP-A------------------------TGSCS-------T-------TQEPQR---A
L--TTTTTSV-G------------------------------------------------
------------------------------------------------------------
-----------------IS----YTRSDEAS---------------NG-Q-DE-DGV---
-----------------------------CA-YEVP--PFTERSDFLTRKAGLLE-----
-------QFLLYKYKMKQPIL-KEDML--KIIHQNHH-----DRFAEILKRASER-----
----IEIIFAVD---------LKE-VDSTR---------QCYD-----------------
-------L----------------------------------VSKLKL-PNN----GRVR
----GGRGLPKTGLL-------MNLLGMIFMKGNC------ATEE---DIWKFLSMM---
-----RVY-AGR----KHFIYGEPRKLITKDLVRL------KYLEYRQV-PDSDPPRYEF
----LWGPKAHIETS--KMKVLEFLAKVNETVPS----A-FPIYYEE---ALRDEEERSS
LL-PL-----S-HN----------------------------------------------
----------------------------------------------------------WN
--------------------SCTIFD-----------------------KLY---FQFIL
FKI---------------FFS-NF-------------S----------------------
------------------------------------------------------------
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------------------------------MPR---------------------------
----------------------GHKKK---------------------------------
-GH-----------------SRAKRH-HACGGSQG---LQGDHRMSGTG--------SA-
-SL-------------------PVS-QAN-SPSISEACTPWGAV-F-------------S
---------ASS-------------------GANTSSTGFDKG---------AEG AVGCG
DAECLGTFKAESIPQ-LISNDAL---TKNASML VE------FLLEKF-KKSEEF--TD--
------------------------------------------------------------
----ADM---QRVVSKKYKIQFSDILRKSSLRMEMIFGMQLKKINDSSETYA-IVSKLGL
STAEIL-SGKRGL-PKMG---LLM----------TILGL----------IF--------T
-KGNR----A-T--EEEIWKFLNILGVY--AGKKHLIFGEPRRFITKDLVEQK-------
---------YLEICKMSKGKS---P--KYDFLWGSRAHIETSKMKVLEVWAKINDT---I
------PSFFPTMYDEALKEKIERAERESV-VLVPTAAAGRDCPL----CMSCSFYK---
------------------------------------------------------------
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--------------------------------------MPHH------------------
-------------HDDQRNQ-CGSLE-K----------------GLQA----QRV-AQG-
-------------LVGAQAPGAQE------------------------------------
-----------------------------------------------------------E
---E-----------------------VATS-----------------------------
------------------------------------------------------------
--------STVI----PSI--LEEA---G---------------------AAE-------
----------T--------------------------------------PSPP---GS--
--PEGDSS---SPTSLA-S--K--HHSDE----------------G-SSS-EEEEGP---
------------S------TYKDPE------------D-------SASKRMSDLV-----
-------HFLLLKYRFKDPIT-KAEML--NIVLNDYQ-----DHFPEIFMKASEC-----
----MQMVFGVD---------VKE-VDPAG---------HSYV-----------------
-------L----------------------------------VTTLGL-TYY----EELN
---DD-QRFPKSGLL-------IIMLGLILFEGDC------APEE---VIWEALGGM---
-----GVH-AGS----EHYIYGEPRKLITQDWVQE------GYLEYRQV-PDSDPACYEF
----LWGPRAHAETS--KMKVLEYVLKVNRSDHR----S-FPLLYEE---SVRDEEE---
------------------------------------------------------------
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------------------------------------------------------------
------------------MSQ--LSKNLGDSSPPAEAPKPP-------------------
----------VYSRPTVLMRAP-----PASSRAPPVPWDPPPIDLQA-SLAAWQAPQPAW
EAPQGQLPAPV---VPMTQPPALGGPIVPAPPLGGPMGKPPT------------------
---------------PGVLMVHP-PPPGAPMAQPPTPGVLMVHPSAPGAPMAHPPP-PGT
PMSHPP-------------------------PPGTPMSH---------------------
-----P---------P------------------PPGTPM----A-------HPPPPG--
------------------------------------------------------TPMAHP
PPPGTP--MA-------------------QPPPPGTPMAQP---PAPGVLMAQPLTPGVL
MVQPA-------------APGAPMVQPP----PAAVM-------------------TQPP
PSGAPMAKPPGPGVLMIHPPGARAPMTQPPASG---------------APMAQPAAPPAQ
PMAPPAQPMASWAPQAQPLILQIQSQVI----R-------APPQV---P-----------
-------Q---GPQAPPAQLATPPGWQATSPGWQATPQGWQATPLTWQTTQVTWQAPA--
----------IAWQVPPPV-RQGPPPIRP-------------GPPPIRPGPPPVR---QA
PPVIRQ---APPVIRQAPP-VI----------------------------RQAPPVIRQA
-PP---------V-----------------------------------------------
--------IRQAPPLIRQAPP-PI------------------------------------
-----------------------------------------------------------R
--------------PAPQVLATQPPLWQALPPPP-----P---------------LRQAP
QARLPAPQVQA------------APQVPTAPPATQ-------VPAAPPAGPQVPQP---V
L--PAPLSAP----------------------------------------LS--------
---------AP-----------QAVH--CPSIIWQAPKGQPPVPHE--------------
------------------------------------------------------------
------------------------------------------------------------
---------IPTSMEFQEVQQ-TQ-AL--AWQAQKAP-----THFWQPLPAQEAQRQ---
----APPMVQLE-------QPFQGAPPSQKAVQIQL-PPQQAQAS--GPQAELPTLQLQP
SWQTPPAVLQAQPGPPLAAANFPLGSAKSLMTP-SGESRASSIDRRGSS-KE----RRTS
SK--ERRAPSKDRM----------IFAATFCAPKA----VSAARAHLPATWKNLPATPET
FAPSSSVF-PAT----SQFQPASLNAFKGPSAASE----TPKSLPYAL---QDPFACVEA
LPAVPWVPQPNMNASKASQAVPTLLM-ATAAAPQ----A-TATT-QE---ASKTSVEMPR
RS-----------------------GKA--------------------------------
--TRK-----KKHLEAQE-DSGGHTLA-------------------------------FH
--D-WQGP----RPWENLN--LSDW--EVQSPVQ-V--LGDWEHPNTPRGLSGWEGPSTS
-RI---------------LSG---WEGPSTSWALSAWEGPSTSR-A--------------
---------LGLS---------------ESPGSPLPLVVSEVA-------------G---
VSPGSSATQDNSKVE-AQSLSPL---DERANALVQ------FLLVKD-QAKVPV--QR--
------------------------------------------------------------
----SEM---VKAIIRESKDECLGIINRANSKLECAFGYQLKEIDAKNHAYI-IINKLGY
HAGDLV-ASCLDR-PKFG---LLM----------VVLSL----------IF--------M
-KGNC----V-R--EDLIFNFLFKLGLD--VRETNGLFGNTKKLITEVFVRQK-------
---------YLEYRRIPYTEP---A--EYEFLWGPRAFLETSKMLVLRFLAKLHKK---D
------PRCWPFHYLEALAECEWEDTDEDE-PDS--T--DSA-------RGP--------
---TSRPPPR--------------------------------------------------
------------------------------------------------------------
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--------------------------------------MPRGQK---SKLRAREKR-RQA
-RG-----GLEDL-----------------------------------------------
-ID-------------ALAILEEE------------------------------------
-----------------------------------------------------------E
-ASP-------------------------PSASA-----C---------------LKDVS
QS-S-L------------------------DGTSN-------N-------PHGLQE---A
Q--STSTSAT-A------------------------------------------------
------------------------------------------------------------
-----------------AS----HTRHPEGV---------------ND-Q-ME-ERP---
-----------------------------RC-TQDLEATDSFPRGPVDEKVIILV-----
-------HYLLYKYQMKEPIT-KADML--RNVTQMSK-----SQFPVILSRASEH-----
----LELIFGLD---------LKQ-VEPNK---------HIYV-----------------
-------L----------------------------------VNKLDL-GCD----AKLS
----DETGVPKTGLL-------MTVLGIIFTNGNC------VAEE---EVWKVFNTM---
-----GLY-DGI----EHFMFGEPRKLLTKDLVKE------NYLEYQQV-PNSDPPRYQF
----LWGPRAHAETS--KMKVLEFLAKVNNTAPS----E-FSNWYTE---ALQDEEERAR
AR-VAAKARIS-AT----------------------------------------------
----------------------------------------------------------AG
--------------------ARS--K-----------------------VKSS-KSSQLR
------------------------------------------------------------
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---------------------M-------SLVSQNACH----------------------
------------------------------------------------------------
------------------RNAETT------------------------------------
-----------------------------------------------------------V
-DY---------------------------------------------------------
-----------------------------------------------------------S
D--FHGEMQA----------------TNASGS------------P-T-------------
---------------------------------------------------SM------L
----------VPDAPQ----GLQAPIDSQGA---------------SASQ-AA-------
---------QDP----N--DFEV--LID-EQSRRLGA---LRVHDPLEDRSIALV-----
-------NFMRMKSQIEGSIQ--QTEM--LEFLREYS-----DQFPEILRRASAH-----
----LDQVFGLN---------LRV-LDPQA---------DTYK-----------------
----------------------L-------------------ISKRGL-QTT----DRIA
----ESLDMPKAGLL-------ALVLGHILLNGNR------AREA---SIWDLLLKV---
-----DVL---DEPQRINIPFGSTRNLLTTDFLHM------RFLEYWPV-YGTNPLEFEF
----LWGSRAHK--EITKM-----------------------------------------
------------------------------------------------------------
--------------------------E-------------------------------AL
K-----------------------F---VA----------------EAHDEEP-------
------------------------WSWPE-EYN------------KALEADKAKER---S
---------------------------------------------------------QA-
AG---L--------E-FWSED---TMNDKANDLVQ------LAINVT-EELLPI--HQ--
------------------------------------------------------------
----DEL---LAHTGKEFEDVFPNILSRATLILDLFYGFSLIEVDTSEHIYL-LVQQPES
EEEQMM-LESLGR-PTQE---YLM----------PILGL----------IF--------L
-MGNR----V-K--EASVWNLLWRFGVD--VGRKHAI--------TCKLMRQR-------
---------YLECRPLSYSNP---V--EYELLWGPRAHLETTKMKALEYMARLYRK---Q
------PQDWPEQYREAVE-----------DEEARARSEATAMFF----FGP--------
---M--------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
--------------------------------------MPRGQK---SKLRAREKR-RQA
-HG-----ETPGL-----------------------------------------------
-QA-------------AQAPAA--------------------------------------
------------------------------------------------------------
----------------------EPPSPTTPPSSP-----P---------------SGGTP
QSSP-A-------------------------AGR----------------PQGPRR---S
P--SPTTPTK-A------------------------------------------------
------------------------------------------------------------
-----------------FA----SLRVDDGA---------------RC-P-EE-THP---
-----------------------------GP-SQAAGPMESYRRDPLTRKASMLV-----
-------AFLIERFKSKEPIS-KAAML--KIVNRKYR-----DQFPEILRRATLR-----
----LELVFGLE---------LKE-VDPSG---------QSYL-----------------
-------L----------------------------------NSKLDL-TTE---GSL-G
----GGGDLPKTGLL-------MTLLAVIFMKGNR------ATEE---EVWEFLNAL---
-----GVF-AGR----KHLIFGEPHQLLTEDLVQE------KYLEYRQV-PRSDPPCYEF
----LWGSRAHAETT--KMKVLEVLAKINDTVPS----S-FPVLYEE---ALRDEQERAA
AG-IPGRASVT-TL----------------------------------------------
----------------------------------------------------------VR
--------------------RRA--R-----------------------ALAS-RHSHK-
------------------------------------------------------------
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---------------------------------------MAQKMDCGAGLLGFQA-----
--------------------------------------------------------EASV
EDST-LLMQTLM-------EAIQ--IS-EAPPTNQA--TA--------------------
------------------------------------------AASGQNASPQSSQPLTA-
N------------------------------------------------EMAD-------
------IQVSAAAARPKT------------------------------------------
-----------------------------AF---------------KAQ-----------
-------------NAT----------------TKGPNGVYDFSQAPNMKDMP-NTQSKAT
F-------------------KPQNATP--KGPNAAYD-------FSQAATT---------
----GELT-NKSEMAFKAQSAT-AKVGPNA---------T-YNFSQSLNGNEMANNQPKA
------------------------------------------------------------
----------------------------------------------AFKAWNDTTKAPVA
-------------------------------NTQT-----------QNL-----------
----DQA---KMATSQ--------ANLESD--PG---------ISEPDGAAAQTSADGSQ
AQNLE--------------------T---------------------------------R
TIIRGKRTRKINNLNV---------EENSSGDQRRAPLAAGTWRSAPVPVTT-QNPPGPP
PNVLWQTPLV----WQNPS----GWQNQTVRQTP----P-ARQSPPARQTPPTWQNPVAW
HNPVIWPNPVIWQNPVIWPNPI-VWPGPVVWPNPLAWQNPPGWQTPSGWQTPPGWQGAPD
WQG---PPDWPLPPDW-PLPP-DWPLP-TDWPLPPDWIPADWPIPPDWQNLRPSPNLRP-
-SPNSRASQNLGAAQ-PRDVALL---QERANKLVK------YLMLKD-YTKVPI--KR--
------------------------------------------------------------
----SEM---LRDIIREYTDVYPEIIERACFVLEKKFGIQLKEIDKEEHLYI-LISTPE-
SLAGIL-GTTKDT-PKLG---LLL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPLLGDLRKLLTYEFVKQK-------
---------YLDYRRVPNSNP---P--EYEFLWGLRSYHETSKMKVLRFIAEVQKR---D
------PRDWTAQFMEAADEALDALDAAAA--EAEAR----AEARTRMGIGDEAV-----
------SGP--WSWDDIEFELLT-WDEEGDFGDPWS-RIPF----TFWARYHQNARSRFP
QTFAG---------------------P--IISPGGTASA------NFAANFGAIGF----
--------FWVE------------------------------------------------
------------------------------------------------------------
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---------------------M-------SLVSQNALH----------------------
------------------------------------------------------------
------------------GSAETT------------------------------------
-----------------------------------------------------------A
-DY---------------------------------------------------------
-----------------------------------------------------------S
D--GRGEMRA----------------TNASRP------------L-T-------------
---------------------------------------------------SM------L
----------VPDSPQ----SPQTPIDTQGA---------------SASE-AT-------
---------QDP----N--DLEV--LID-EQSRRLGA---LRVHDPLEDRSIALV-----
-------NFMRMKSQTEGSIQ--QTEM--LEFLREYS-----DQFPEILRRASAH-----
----LDQVFGLN---------LRV-LDPQA---------DTYN-----------------
----------------------L-------------------ISKRGI-QTN----DRVA
----ESLDMQRAGLL-------ALVLGHILLNGNR------AREA---SIWDLLLKV---
-----DVF---DEPQRINNLFENTRNLLTTDFVRM------RFLEYWPV-YGTNPLEFEF
----LWGSRAHR--EITKM-----------------------------------------
------------------------------------------------------------
--------------------------E-------------------------------AL
K-----------------------F---VA----------------EAHDEEP-------
------------------------WSWPE-EYN------------KALEADKAKER---S
---------------------------------------------------------QA-
AG---L--------E-FWSED---TMNDKANDLVQ------LTINVT-EELLPI--HQ--
------------------------------------------------------------
----DEL---LAHTGKEFEDVFPNILSRATLILDLFYGFSLIEVDTSEHIYL-LIQQPES
EEEQMM-LESLGR-PTQE---YVM----------PILGL----------IF--------L
-MGNR----V-K--EASVWNLLRRFGVD--VGRKHAI--------TCKLMRQR-------
---------YLECRPLSYTNP---V--EYELLWGPRAHLETTKMKVLEYMARLYRK---R
------PQDWPEQYREAVE-----------DEEARARSEATAMFF----FGP--------
---M--------------------------------------------------------
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-----------------------------------------------------MSEPSKD
PRI---------------------------------------------------------
------------------------------------------------------------
--------PNF----------------------------A---------------GAA-P
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------RP--------------RALG------------------------NL--GG---
----------------------AVVDP--LLASPTPG-PAPPAPAQLVQKAHELM-----
-------WYVLVRDQRKMVIW-FPDMV--KDVIGSYK-----KWCRSILRRTSLI-----
----LARVFGLH---------LRL-VSLHT---------MEFA-----------------
-------L----------------------------------VKALDPEELD-----RMA
----LNSRMPMTGLL-------LMILSLIYVKGRG------ARES---AVWNVLRIL---
-----GLR-PWK----KHATFGDVRKLITEEFVQQ------NYLKYRRI-PYVEPPEYEF
----FWGSRASREIT--KMQIMLFLSRVFKKDPQ----A-WPTRYRE---ALEEARVLRE
ARGPA----------------------------------PCPRSVSGN------------
------------------------------------------------------------
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------------------------------------------------------------
-------------------------------------------MS---------------
-------------LCD-KFM-AFTLE-D----------------ENQD----PQD-DQH-
-------------LKNGQESGGGE------------------------------------
-----------------------------------------------------------E
------------------------------------------------------------
------------------------------------------------------------
------TASVLL----EDT--TGE------------------------------------
---------VA--------------------------------------AAGV---FSVP
KGPHQSSLPV-ISG----C--TPENHPLK----------------GSASS-RQEKGS---
------------M------VE---------------PAQLGPLQKALDDKISDLV-----
-------GFLLLKYRTKQLTT-KEAML--RTIPNNDE-----EDFSVILSQVSEC-----
----MHLVYGID---------VKE-VDPQS---------HSYA-----------------
-------L----------------------------------VTTLGL-TYD----GMVG
-P--Q-QTMPNTGLL-------VMVLGVILLEEDC------ASEQ---AVWEQLSLM---
-----GVY-PGR----KHFIYGEPRKLLTNVWVQE------QYLEYQQV-PGSIPARFQF
----LWGPRAHAETS--KMDVLDFLINVYISEQK----T-LQCVSQE---MLEEEKEWA-
------------------------------------------------------------
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--------------------------------------MPRA-P----------------
-----------------KRQ-RCMPE-E----------------DLQS----QSE-TQG-
-------------LEGAQAPVAVE------------------------------------
-----------------------------------------------------------E
D-AS-----------------------SSTS-TSSSFPSSFPSS----------------
-----------------------------------------------------------S
S-SSSSSWYPLI----PST--PEE--VSA---------------------ADE-------
----------T--------------------------------------PNPP---QSA-
---QIACS---SPSVVA-S--LPLDQSDE----------------G-SSS-QMEESP---
------------S------TLQALA------------DSESLPRSEIDEKVTDLV-----
-------QFLLFKYQTKEPIT-KAEIL--ESVIKNYE-----DHFPLLFSEASEC-----
----MLLVFGID---------VKE-VDPTG---------HSFV-----------------
-------L----------------------------------VTSLGL-TYD----GMLS
---DV-QSMPKTGIL-------ILILSIIFIEGYC------TPEE---VIWEALNMM---
-----GLY-DGM----EHLIYGEPRKLLTQDWVQE------NYLEYRQV-PGSDPARYEF
----LWGPRAHAEIR--KMSLLKFLAKVNGSDPR----S-FPLWYEE---ALKDEEERSQ
ERMATTDDTTA-------------------------------------------------
------------------------------------------------------------
-----------------------MA--------S----------------ASS----SA-
------------------------------------------------------------
---------TGS---------------------FSYP-----------------------
-------------------E----------------------------------------
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--------------------------------------MPLSDQA---------------
-----------------ELR---KME-E----------------DLQG----PEE-APG-
-------------LAGGQQVQGKA------------------------------------
-----------------------------------------------------------S
S-----------------------------------------------------------
------------------------------------------------------------
-----SSASALS----PDT--LLR------------------------------------
---------EA--------------------------------------ATGV---PGAL
ESPPRASC---SPRAAA-D--TEWRQPEE----------------DPRNA-EEESSF---
-------------------P--GR------------RQQEPHFQELLYTKMADLV-----
-------SFLLNKYRRREIST-QVEIL--NQVLDEEQ-----EHFPLIFRQAREC-----
----LQLVFGID---------VQE-VDPPG---------LSWV-----------------
-------L----------------------------------APTLGL-TYD----GLTE
-A--E-DSVPKTGLL-------VMVLGVIVLQGDC------ASEA---DMWESLNLM---
-----GLS-AGR----EHYIFGEPRELLTNEWVQE------QYLVYQRV-RGSRPAHYEF
----LWGPRAHAETS--RQRVLYRLFMVYAILDA----R-ALSGE---------------
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------------------MSQ--LSKNLGDSSPPAEAPKPP-------------------
----------VYSRPTVLMRAP-----PASSRAPPVPWDPPPIDLQA-SLAAWQAPQPAW
EAPQGQLPAPV---VPMTQPPALGGPIVPAPPLGGPMGKPPT------------------
---------------PGVLMVHP-PPPGAPMAQPPTPGVLMVHPSAPGAPMAHPPP-PGT
PMSHPP-------------------------PPGTPMAH---------------------
-----P---------P------------------PPGTPM----A-------HPAPPGTP
------------------------MAHP--PPPGTPMVHPPPPGTPMVHPPPPGTPMAHP
PPPGTP--MA-------------------QPPPPGTPMAQP---PAPGVLMAQPLTPGVL
MVQPA-------------APGAPMVQPP----PAAVM-------------------TQPP
PSGAPMAKPPGPGVLMIHPPGARAPMTQPPASG---------------APMAQPAAPPAQ
PMAPPAQPMASWAPQAQPVILQIQSQVI----R-------APPQV---P-----------
-------Q---GPQAPPAQLATPPGWQATSPGWQATPQGWQATPLTWQTTQVTWQAPA--
----------ITWQVPPPV-RQGPPPIRP-------------GPPPIRPGPPPVR---QA
PPVIRQ---APPVIRQA--------PPVIRQAPPVLRQAPPVLRQAPPVIRQAPPVLRQA
-PP---------V-----------------------------------------------
--------IRQAPPLIRQAPP-PI------------------------------------
-----------------------------------------------------------R
--------------PAPQVLATQPPLWQALPPPP-----P---------------LRQAP
QARLPAPQVQA------------APQVPTAPPATQ-------VPAAPLAGPQVPQP---V
L--PAPLSAP----------------------------------------LSA-------
----------P-----------QAVH--CPSIIWQAPKGQPPVPHE--------------
------------------------------------------------------------
------------------------------------------------------------
---------IPTSMEFQEVQQ-TQ-AL--AWQAQKAP-----THFWQPLPAQEAQRQ---
----APPMVQLE-------QPFQGAPPCQKAVQIQL-PPQPPQTS--GPQAELPTLQLQP
SWQTPPAVLQAQPGPPLAAANFPLGSAKSLMTP-SGESRASSIDRRGSS-KE----RRTS
SK--ERRAPSKDRM----------IFAATFCAPKA----VSAARAHLPGTWKNLPATPET
FAPSSSVF-PAT----SQFQPASLNAFKGPSAASE----APKSLPYAL---QDPFACAEA
LPAVPWAPQPNMNASKASQAVPTLLM-ATAAAPQ----A-TATT-QE---ASKTSVEMPR
RS-----------------------GKA--------------------------------
--TRK-----KKHLEARE-DSRGHTLA-------------------------------FH
--D-WQGP----RPWENLN--LSDW--EVQSPVQ-V--LGDWEHPNTPRGLSGWEGPSTS
-RI---------------LSG---WEGPSTSWALSAWEGPSTSR-A--------------
---------LGLS---------------ESPRSPLPLVVSEVA-------------G---
VSPGSSATQDNSKVE-AQSLSPL---DERANALVQ------FLLVKD-QAKVPV--QR--
------------------------------------------------------------
----SEM---VKVIIREYKDECLDIINRANNKLECAFGYQLKEIDTQNHAYI-IINKLGC
PTGDLV-ASYLDR-PKFG---LLM----------VVLSL----------IF--------M
-KGNC----V-R--EDLIFNFLFRLGLD--VRETNGLFGNTRKLITEVFVRQK-------
---------YLEHRRIPYTEP---A--EYEFLWGPRAFLETSKMLVLRFLAKLHKK---D
------PRCWPFHYLEALAECEWEDTDEDE-PDS--SDSDSA-------RGP--------
---TSRPPPR--------------------------------------------------
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--------------------------------------MLFVA-----------------
----------------------ARAE-E----------------GVGQ----ARV-HRG-
-------------LCVAVLSQTEE------------------------------------
-----------------------------------------------------------Q
K-A---------------------------------------------------------
------------------------------------------------------------
----ASSSSTLI----AGT--LEE------------------------------------
---------VP--------------------------------------DSGS---LSPA
QSPRGASS---SLTVTD-D--TLWSQSNE----------------VSSS--NEEEGP---
------------S------TSPDPA------------HLESLFREALDEKVAELV-----
-------HFLLRKYQIKEPVT-KAEML--ESVIKNYK-----NHFPEIFSKASEC-----
----MQVIFGID---------VKE-VDPAG---------HCYV-----------------
-------L----------------------------------VTCLGL-SYD----GLLG
---DD-QSTPKTGLL-------IIVLGMIVMEGSC------APEE---AIWEALSVM---
-----GLY-DGR----EHSAYWELRKLLTQDWVQE------NYLEYHQV-PGSDPVRYEF
----LWGPRALAETS--YVKVLEHVARVNARVRI----S-YPSQSNR---CEATGESGGV
YMP---------------------------------------------------------
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------------------------QLWRSPSGSP---HLQ---------------LS---
--D---------------------------------------------------------
--------FHF--------------GSQLEGR------------LSLRRASSVKQR----
----ELSQGWPLN---------KK---------------------------------RTL
SKDSD-----LPTRRGGAGCTLPLPAVSPGK---------------R-WG-E--------
------------------------------NSESLIESEPLF-TYTLDEKVDELV-----
-------RFLLLRYQAKQPVT-KAEMV--TNVINRYT-----GYFPMIFRKAREF-----
----IEILFGIS---------LRE-VDP-E---------DSYV-----------------
-------F----------------------------------VNTLAL-SCE----GSVS
----DEQGMPQNHLL-------FLVLSIIFMKGTC------ASEE---VIWDVLSGI---
-----GLW-SSPAGF------------------LD----VLSQLAPWES-EGPE------
----ALCEEARLSSAE--------------------------------------------
-RSL----R------P------GPSSSV--------------------------------
----------------------GPRQE-------------------------------NG
CRG------------------LRGPHD-RRSGP------EEDEVHSAGMSSLL-------
------------------------QSTPK-SPP----------------QGPSQCPPQNP
---------LSSC------------------SSPMN----EES-------------SSQ-
KEEDASTCPGLPESE-FFFTYTL---GEKVA---E------FLLLKY-QTKEPI--TE--
------------------------------------------------------------
----SEM---LTVVITKYQDYFPMILEKAGEFIKLLFGLALIEVGPD-HFYV-FANTVDL
TGEG---SDDKGR-SKNC---LLI----------LILSM----------IF--------I
-KGSC----A-S--EEVIWEVL--------------KAIGVYE-----STKQK-------
---------VLEFLAKLNNSI---P--ISFPSWYKNALKDVEERAQAIISTADDAT---A
------MPSASFSFMSSNFS------YPE-------------------------------
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-----------------------------------------SH-----------------
---------------------KASMF-D----------------EDQH----PHN-IWG-
-------------E---------E------------------------------------
-----------------------------------------------------------G
KWSPLVSSS------SS---ST-----SFFL----------------------PPFTS--
-----------------------------------------------------------S
SSFASSSSYPLL----PPP--PEDT-----------------------------------
---------AG--------------------------------------GEDS---PVIP
SAPPNSPTSVTSSESSA-E--IPEKLSEE----------------SC-SI-KAEGGQ---
------------E----------------------IAGIESSLQDAAFQKMIDLV-----
-------AFLNLKYHTSKTTT-KEEIL--RTIFSNDQ-----HLFPIVFTQACEY-----
----MLLVFGIE---------VQE-VDPQI---------LSYI-----------------
-------L----------------------------------VPALGL-TYD----GMVD
-A--E-QSVPKTGLL-------VMVLGIIIRDGNH------SLEN---DMWNALSRL---
-----GVY-PDM----EHFIYGNPRDLLTNVWVQE------QYLEYREI-PGSDPACYEF
----LWGPRAHAETS--RKKVIELWLKIHTRDPR----S-FGLLMAE---FRAKKRR-IQ
------------------------------------------------------------
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--------------------------------------MPYGQK---SKLRAREKR-RQA
-RS-----DTHSV-----------------------------------------------
-KG-------------AQTTTAEE------------------------------------
-----------------------------------------------------------E
-GSP-------------------------SSSSP-----P---------------SRDSP
ESSP-A------------------------AAGI----------------PQEPPR---V
Q--PITTATVVD------------------------------------------------
------------------------------------------------------------
-----------------AS----GTGASGGA---------------EG-Q-DE-GGP---
-----------------------------SS-SAAPAPTERSQRDPVTRRVSTLL-----
-------QFLLHKYKMKEPIT-KAEML--KIVNKRYK-----EHFSDILRRATEH-----
----MELVFGLD---------LKE-VDSTG---------QSYT-----------------
-------I----------------------------------VSKLEI-TKE---ENL-S
----GGRGFPKTRLL-------MPLLGIIILNGNR------ATED---EIWEFLSFL---
-----GIY-DGK----RHFMLGDPRRLITRDIVKE------TYLEYQEV-PNSYPPRYEF
----LWGPRAHAEAN--EEKVLEFLVKINDTDPR----A-FQALYEE---TWVDEAKRA-
------------------------------------------------------------
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--------------------------------------MSHA-P----------------
-----------------KHQ-HYTLE-Q----------------DHQA----QTE-AQG-
-------------LVAIQVPAAEN------------------------------------
-----------------------------------------------------------L
G-T---------------------------------------------------------
------------------------------------------------------------
-----------------QD--EVEV---P---------------------TAV-------
----------V--------------------------------------PSTH-------
QSPQKSFS---ISTSTS--------ISDE----------------D-SSS-P--------
---------------------EASV------------GAESSSRDPLEDTVTDLV-----
-------QLLLLRYQMRQPIT-KVEML--KVMSKRSK-----NQFPVIFKKACEC-----
----LEMVFGIN---------VKE-VGPPI---------HSYV-----------------
-------L----------------------------------VNSLDL-TYD----EVVI
---N-GQGMPKNGLL-------IIILGVIFLEGNR------IPEE---DIWELLNIM---
-----GVY-AGS----EHAIYGEPRQLITRDWVQE------KYLEYQEV-PNSDPARYEF
----LWGPRAHAETS--KMKVLEFLAKLNGTDPS----S-FSPWYEE---ALRDEQERAQ
ARIALTGSATE-------------------------------------------------
------------------------------------------------------------
-----------------------GL------LAQ--------------------------
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-------------------------------------------RDPLTKEVDTLV-----
-------QLMLQTYKTKKLVI-KEDML--KIVNKKYK-----SRFHEILRRASFS-----
----TEVVFGID---------LKE-IDSVK---------PSYA-----------------
-------L----------------------------------VSKMDL-PND----GRLS
----RGRGLPKTGVL-------MILLGVIFMKGNC------ASEE---KIWEFLNKM---
-----RIF-AGK----RHFIFGDPRKLITQDFVKL------KYLEYRQV-PNSDPPSYEF
----LWGPRAHAETI--KMKVLEFLAKINDTVPS----A-LPSLYEE---ALRDEEERAR
ATVP-DRADPT-AMASAHSNAFLCNVKNTVL-----------------------------
------------------------------------------------------------
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--------------------------------------------------------MAE-
----------------------------------------------------------GS
FS-----V-Q-------SESYSVEDMDEGSDEVR--EEEMVEGNDYE----EFGAFGGYG
TLTSFDIHI--LRAFGSLG-----------------------------PGLRILSNEPWE
LENP-VLAQTLV-------EALQ--LDPDTLANETAARAA-------------NVARAAA
---S----------NRA-ARAA--------------------AAAARTAFTQV---VASH
R-------------------------------------------------VAT-------
------PQVSGEDTQPTTYAA--EAQ--------------------GPTPEPPLASPQTS
------QMLVTSEMAAPGAPVT-STKSQTGS---------------PAQ-----------
-------------EAA----------------TEGPSSACAFSQAPCAREVD-TTRPSTA
FLGQ----------------------------NDVFD-------FTQPAGV---------
----SGMAFPRPKRPAPAQEA--ATEGSSA---------AS-GVPQTGPGREVAATRPKT
T-----------------------------K-----------------------------
------------------------------------------------------------
--------------------------------------------------------SGKA
LAKTRWVEPQNVVAAA--------AAKA-KMATS---------IPEPEGAAA--ATAQHS
AE-----------------------P---------------------------------W
ARMGGKRTKKSKHLDDEY--------ESSE-EEREPPAVPPTWRASQPSLT---------
---------V----R---------------------------------------------
----------------------------------------AQLA----------------
-----------------PRRP-----------------------------V----A----
-PRSQIPSRHVLCLP-PRNVTLL---QERANKLVK------YLMIKD-YKKIPI--KR--
------------------------------------------------------------
----ADM---LKDVIREYDEHFPEIIERATYTLEKKFGIHLKEIDKEEHLYI-LVCTRDS
SAR-LL-GKTKDT-PRLS---LLL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPFLGDLRKLITDDFVKQK-------
---------YLEYKKIPNSNP---P--EYEFLWGLRARHETSKMRVLRFIAQNQNR---D
------PREWKAHFLEAVDDAFKTMDVDMA--EEHAR----AQMRAQMNIGDEAL-----
------IGR--WSWDDIQVELLT-WDEDGDFGDAWA-RIPF----AFWARYHQYILNSNR
ANRRA------TWRAGVSSGTNGGASTSVLDGPSTS-ST---IRTRNAARAG--------
----ASFFSWIQHR----------------------------------------------
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------------------------------------------

MPLSPNIPCPSFEQGFQKPNFILELVDEASSIF-------SSSLHFLFPSSSSSSFSSSS
SSLILRSPGDKDMTAAGMPSLLQSSAESRQSRPE--------------------------
----------GEDSPSLLQSPPEGKDSQ---SPLQIPQSPPEGEDSLSPLQIPQS-----
-PPEGEDS-----LSPL--------QISQSPPEGEAVQSPLQNPASSLFPS---------
TLLSVFQSSPESTQSPFEGF--PQSPLQIPVTSSFPSTLLRVFQSSPESSQSPFEGFPQS
PPQIPVSSSFSSTLLSLFQSSSESSQSPFEGFPQSPLQIPVSASF-STLLRLFQSSPESS
QSPFEGFPQSPPQI----------------------------------------------
------------------------------------------------------------
--------------------------------------------PVTSSFPSTLL----S
LFQSSPESSQST---FEGFPQSPLQIPLSSSSSSPLLSLFQSSPESSQSTFEGFAQSPLE
IPQ----------------------------------------SPTEGDNSQSPLHSPRS
PPEGEDSLSPL-------------------------------------------------
--------------------QIPPEWEDSLSPLHFPH-----SPPQGEDSQSSLQS----
---------------------PG-PAQSPLYSPQSLPEGTDSQSPVKRPQSPPEGEDSLS
PLYIPQ---CPPEGEDSLSSLQFPHSPPVRKASLSPLQIPPCPPDGEDSQSPLQT--PQS
-P--PEWEVSLSPLRFP---HSPPQG-E----------------DSQSSLQSPVI-ICS-
-------------SS---------------TSLS-----------------LPQ------
---NFPERPQRP-----------------------------------PEGPAQSP--LQK
P-----------------------------LSSF-SYTLASLLQSPH----------GSP
Q--------------------------------------------SPPEGPAQSPLQRPV
SSFSSTSL-SLS----QSS--PESPESPPEGPAQRPLQSPVSSFSSTSLSLSQSSP----
----ECPQSPP--------------------------------------EGPA---QSPL
QSAVSSFS--------S----TSLSPVSE----------------ESSSP-VDED-T---
------------S------TSDTLLESESLTDSESLIESEPLFTYTLDEKVDELV-----
-------RFLLLKYQAKQPVT-KAEMV--TNVINRYR-----GYFPMIFRKAREF-----
----IEILFGIS---------LRE-VDPE----------DSYV-----------------
-------F----------------------------------VNTLEL-SCE----GS--
VS-DE-QGVPQNHLL-------FLVLSIIFMKGTC------ASEA---VIWDVLSGI---
-----GVR-AGR----EHFIFGEPRELLTKVWVQE------HYLEYREV-PNTAPPRYEF
----LWGPRAHSEIS--KRKVVEFLAMLNNTVPI----S-FPPSYKE---ALKDVEERAP
GHNLTPQMTPL-------------------------------------------------
------------------------------------------------------------
-----------------------PQ------TVQ----------------APS--V----
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---------VSP---------------------SFSS-----------------------
------------------E-----------------------------------------
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---------------------M-------SVVSQNARQ----------------------
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------------------GRAETT------------------------------------
-----------------------------------------------------------A
-DY---------------------------------------------------------
-----------------------------------------------------------S
D--SQGEMQA----------------TNASGP------------P-N-------------
---------------------------------------------------SM------L
----------VPEAAQGL----EIPDDPQGA---------------SAPQ-AA-------
---------QDP----R--DIEV--LID-EQSRRLGA---LRVHDPLEERSVALV-----
-------NFLRMKSQSEGSIR--QSEM--LEFLNEYS-----DQFPEILRRASAY-----
----LDRVFGLN---------LRV-LDPQT---------DTYN-----------------
----------------------L-------------------ISKPGP-QTT----ERLA
----ETLDMPKAGLL-------ALVLGHILLNGNR------AREA---SIWDLLLKV---
-----EVI---DETQRINNLFGNTRNLLTTDFVQM------RFLEYWPV-YGTNPLEFEF
----LWGSRAHR--EITKM-----------------------------------------
------------------------------------------------------------
--------------------------E-------------------------------AL
K-----------------------F---IA----------------EAHDEEP-------
------------------------WSWPE-EYN------------KALESDKAKER---S
---------------------------------------------------------QA-
AG---L--------E-FWSED---TMNDKANDVVQ------LAINGT-EELLPI--HQ--
------------------------------------------------------------
----DEL---LAHTGKEFEDVFPNILSRATLILDLFYGFSLIEVDASDHIYL-LVPQPES
EEEQVM-LESLGR-PTHE---YMM----------PILGL----------IF--------L
-MGNR----V-K--EAKIWNLLRRFNVD--VGRKHAI--------TCKLMRQR-------
---------YLECRPLSYSNP---V--EYELLWGPRAHLEITKMKALEYMARLYRK---Q
------PQDWPEQYREAVE-----------DEEARARSEATAMFF----FGS--------
---M--------------------------------------------------------
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------------------------------------------------------------
------------------MSL--VSQNSRRRRRRGAK---ATA-----------------
----------H-NS---EIQAPNAPGLPGDVAGSDVPQGSIDSQILQ-GLCAS-------
---EG-----------------PST------------SVLPT------------------
---------------SAEGPST---------FVPPNIS---EASSASGQPTV-SEG-TGT
SVLPTP---------------S-EG----LSTSGPPTMS---------------------
-----KGLCTSVTLAASEGQN------TSRLPTSSEEPST---SL-------PPTVSERP
-S----------------------TSVPPTPGEGTSTSVPPTA--------FEGPSTSVV
STVSDGPSTS-------------------VPPTPGEEASTS-------VS--LTATEGLS
ISVPATPDEGLS--------TS---VP-----PNVPEG------------LST---SVPP
T------PDEGPSTSVPATSNEGPSTSVLPAAS---------------DKQSTS------
------------------------------------------------------------
------------------------------------------LVPTFSKGSSTSVLPTAT
EGLSTSV---------QPTPGEGLSISVP---------------PTPGEGLSI-------
----------------------------------------------------------SV
----------PPT----------------------------------------------P
GEGLSTS---------VPPTAT--------------------------------------
-----------------------------------------------------------D
GPST--------------------------SVPP-----T---------------PSEGP
SN-SVPP-TAS------E-GPS-S-----------S--V---I-TVP---PT-PGE----
G--PSTLVQP----------------TASNGP--------------GSSVLPTP------
---GEGPSTLFSSSA-----SMDRNPSKCS-VVLPSPGESKA------------------
----------------S------VDSDSECP---------------K-------------
-------GAEGPIEFQVLRDCESPNSITIMGLSTSRVAITLKPQDPMEQNVAELL-----
-------QFLLVKDQSKYPIR-ESEMR--EYIVKEYR-----NQFPEILRRAAAH-----
----LECIFRFE---------LRE-LDPEA---------HTYI-----------------
-------L----------------------------------LNKLGPVPFE-----GLE
----ESPNGPKMGLL-------MMILGQIFLNGNQ------AKEA---EIWEMLWRM---
-----GVQ-RER----RLSIFGNPKRLLSVEFVWQ------RYLDYRPV-SDCKPVEYEF
----FWGPRSHIETT--KMKILKFMAKIYNKDPM----D-WPEQYNE---ALEEDAARAF
AEG---------------------------------------------------------
------------------------------------------------------------
----WQALPHFRRPFFEE----------VAGE------------------VAS-PD----
-SE---------------------------------------------------------
---------VSNY-------------------------S---------------------
---------SKYPPH-SWPESRL---ESKARKLVQ------LFLLMD-STKLPI--PK--
------------------------------------------------------------
----KGI---LYYIGRECSKVFPDLLNRAARTLNHVYGTELVVLDPRNHSYT-LYNRREM
EETEEI-VDSPNR-PGNN---FLM----------QVLSF----------IF--------I
-MGNH----A-R--ESAVWAFLRGLGVQ--SGRKHVI--------TCRYLSQR-------
---------YIDSLRVPDSDP---V--QYEFVWGPRARLETSKMKALRYVARIHRK---E
------PQDWPQQYREAMEDEANRADIGHR-QF----------FVHNFR-----------
------------------------------------------------------------
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--------------------------------------MSRGHQ---SKFRSREKR-RQA
-RG-----DTHSV-----------------------------------------------
-DG-------------AQATAVEE------------------------------------
-----------------------------------------------------------E
-GSP-------------------------PLLLL-----L---------------LGGSP
LSSP-A-------------------------AGI----------------PQGPQ-----
------------------------------------------------------------
------------------------------------------------------------
---SIPPIT---TAAAGAS----GTRAAGGA---------------EG-Q-DE----G--
----------GP-----------------SS-SAAPAPTERSQRDPVTRRVSMLL-----
-------QFLLYKYKMKEPIT-KAEMM--KIINKRYK-----EHFPDILRRASKC-----
----IELVFGLD---------MKK-VNSKG---------QSYA-----------------
-------L----------------------------------VSKLEI-TKE----ENLS
----GCRGFPKTRIL-------MPLLGMICRNGNR------ATEE---EMWEFLNVF---
-----GMY-DGK----RHFIFGEPRKLITKDLVQA------EYLEYRQV-PNSYPPRHEF
----LWDPRAHTEAN--KKKVIEFLAKISDTDPT----A-FQALYEE---IWRDREEQAA
GREW-ARA----------------------------------------------------
-----------------------------------------------------------G
--------------------LNIMA------------------------------RL---
------------------------------------------------------------
------------A-----------------------------------------------
------------------SGQNV---N-SSSCI---------------------------
------------------------------------------------------------
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--------------------------------------MPRGQK---SKLRAREKR-QRT
-RA-----QTQDL-----------------------------------------------
-KV-------------GQATAAEK------------------------------------
-----------------------------------------------------------E
-ESP-------------------------SSSSS-----V---------------LGDTP
SSSL-A-------------------------LGI----------------PQKPQR---E
P--PTTPAAAAMSGTG--------------------------------------------
------------------------------------------------------------
--------------------------PDEGE---------------ES-Q-DEENA----
-----------------------------SS-SQASASAESSLKDPLTRKTKMLV-----
-------QFLLYKYKMKEPTT-KAEML--KIISKKYK-----EHFPEIFRKVSQR-----
----TELVFGLA---------LKE-VNPTT---------HSYI-----------------
-------L----------------------------------VSMLGP-SND----GNES
----SAWSLPRNGLL-------MPLLSVIFLNGNC------AGEE---EIWEFLNML---
-----GIY-DGK----RHLIFGEPRKLITQDLSLC------RNQQD-ES-PGV------F
----GQGE----------------------------------------------------
------------------------------------------------------------
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---------------------------------------------------------PC-
SDSLSLL------SL-SSSNPTF---SPQACEVVH------YLLVKD-QTKLPI--HR--
------------------------------------------------------------
----TDI---VNTVIKEYKDMTTEIINRAGQMLEQVFGLELKEIDDKAPAYV-LLNKLEP
LEDDAP-RPKHDT-AKMG---LLM----------VILSL----------IF--------M
-KGNS----A-K--EGMVWDMLRKMRLN--PDKKHPLFGDVKKLVTDEFVHQR-------
---------YLEYNRIPYTDP---E--EYEFLWGPRAFLETSKMQVLRFVAKIQKR---D
------PRSWAVQYNEALREE---------------------------------------
------------------------------------------------------------
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--------------------------------------MPRPR-----------------
-----------------KRR-RCMVE-G----------------QPEA----QSV-AVS-
-------------MEEDSSSSSSTYSS---------------------------------
------------------------------------------------------------
--S-------------------------SSSTYSSSFPSSFS------------------
------------------------------------------------------------
---STSSSYALT----SGN--SEEG-----------------------------------
---------CA--------------------------------------ASRA---SSPS
HSPPGAGS---SCTDMI-S--SPRSQVSA-------------------DS-EGMESL---
------------G------SSQALP------------CGTSMSTGEMDAKVDELV-----
-------KYLLFKYLMKEPVS-KAEIL--SNIIRNYQ-----DYFAVIFREASEC-----
----MQLVFGLE---------LKE-IDPAS---------HTYI-----------------
-------L----------------------------------TVALEL-TYD----GM--
MT-DV-QGLPKTGLL-------IMVLSIIFMEGNC------VRED---MVWGILNNI---
-----GLY-AGT----EHFIYGDPRKLITDNFVQE------GYLEYRQV-PGSHPPSYEF
----LWGPRACAETT--KMKILTFLTSINGSDPR----S-YPVWYAE---ALRDEEQQE-
------------------------------------------------------------
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--------------------------------------MPRGQK---SKLRAREKR-QRT
-RA-----QTQDL-----------------------------------------------
-KV-------------GQATAAEK------------------------------------
-----------------------------------------------------------E
-ESP-------------------------SSSSS-----V---------------LGDTP
SSSL-A-------------------------LGI----------------PQKPQR---E
P--RTTPAAAAMSGTG--------------------------------------------
------------------------------------------------------------
--------------------------PDEGE---------------ES-Q-DEENA----
-----------------------------SS-SQASTSTERSLKDPLTRKTKMLV-----
-------QFLLYKYKMKEPTT-KAEML--KIISKKYK-----EHFPEIFRKVSQR-----
----TELVFGLA---------LKE-VNPTT---------HSYI-----------------
-------L----------------------------------VSMLGP-TND----GNQS
----GAWSLPRNGLL-------MPLLSVIFLNGNC------AGEE---EIWEFLNML---
-----GIY-DGK----RHLIFGEPRKLITQDLSLC------RNQQD-ES-PGV------F
----GQGE----------------------------------------------------
------------------------------------------------------------
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----------------MPA---A-----------------------GMPPLPQSPP---E
IPPQGPPKISP--------------------------------------QGPP---QSPP
QSPLNSCS--------S-P--LLWTRLDE----------------ESSSE-EEED-T---
------------A------IWQAL------------PESESLPRYALDEKVAELV-----
-------QFLLLKYQTKEPVP-KAEML--TTVIKKYN-----DYFPMIFGKAHEL-----
----IELIFGIA---------LTE-MDPDN---------HSYF-----------------
-------F----------------------------------EDPLGL-TYE----GS--
LM-DD-QGMPQNCLL-------ILILSMISIKGSC------VPEE---VLCEVLSAI---
-----GVC-AGR----EHFIYGNPRKLLIIDWVQR------KYLEYREV-PNNAPPRYEF
----LWGPRAHSEAS--KRKNKVRLIFAYPYHVTLLFLQ-IKDIYLALLGLFKKVAEIKS
------------------------------------------------------------
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--------------------------------------MDPPE-----------------
-----------------NSQN-AN-L-D----------------STQF----ERE-TKD-
-------------LEGAQ------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------TVATT----SE------------------------------------------
---------------------------------------------------NG---LDSS
QSAQRTSE---FSADIN-S--PAEV------------------------P-SVGAPG---
------------G------QVGEAF------------GPDSSRQDMLNSKVIDLI-----
-------LFLLLKYRRKQQTC-KAEIL--YMVIRGYE-----EHFPVIFAKASDC-----
----LRLTFGLE---------IVE-RNPRV---------HSYS-----------------
-------L----------------------------------VHALGL-TYD----VM--
QH-GF-PGVPKIGLL-------IIVLCIIFIEDNC------ASEQ---VLWRILNNV---
-----GLY-AGR----DHFVYGDPGVLITEHFVQE------GYLECRQV-ADSDPPTKEY
----LWGPRAHAETT--KMKLLKFFASIVKQDPR----S-YPTRYAE---ALKDEIERA-
------------------------------------------------------------
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------------------------------------------------------------
--------------------------------------MPRGQK---SKLRAREKR-RRV
-RS-----ETQGL-----------------------------------------------
-RG-------------AQATSAEI------------------------------------
-----------------------------------------------------------K
-SP--------------------------ESPSP-----V---------------SGGTR
LSTP-A-------------------------AGT----------------CQQPQR---A
P--AT-GSPDAR------------------------------------------------
------------------------------------------------------------
-----------------VS----RPGSDVGA---------------KS-Q-VQ-KSR---
-----------------------------NF-SRASTSSESSHTDPLTRRVGMLM-----
-------QFLLERYKMKEPII-KSDML--KLVNKKYK-----LHFPEILRRAAER-----
----MELVFGLD---------LKE-VKPNG---------HSYT-----------------
-------L----------------------------------VSKLDL-SDD---GTL-S
----GGWGLPKNGLL-------MPLLGVIFLNGNR------ASEE---EIWEFLNIL---
-----GVY-DGK----KHLIFGEPRKLITEDLVQE------KYLEYRQV-PNSDPPRYEF
----LWGPKARAETS--KMKVLEFLAKVNGTIPS----A-FPVHYEE---ALRDEEERAQ
AK-TAARARAA-AK----------------------------------------------
----------------------------------------------------------AS
--------------------ARS--K-----------------------ARAR-SKAAGI
PPA---------------PSE-V-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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----------------------MIVLGLIFMKGNT------VKET---EVWDFLRRL---
-----GVY-PTK----KHFIFGDPKKLITEDFVRQ------RYLEYRRI-PHTDPVDYEF
----QWGPRTNLETS--KMKVLKFVAKVHNQDPK----D-WPAQYCE---AGGRENEPRK
RISV-AFQCV--------------------------------------------------
------------------------------------------------------------
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---------------------------------------MSDT-----------------
---------------SE-SGA----------------------------GLTSFQAEASE
KDSS-SMMQTLL-------TVTQ--NVEVPETPKAS------------------KA----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------T-----------
-------------EV---------------------------SKTPEAQEAP-ATQASST
-TQLTDTQVLAA----EN--KSLAADT--KKQNADPQ-------AVTMPAT---------
----ETKK-----VSC--------------------------------------------
------------------------------------------------------------
--------------------------------------------------------VA--
-------------------------------DMKV-------------------------
----N-T--KAQETEA--------AASQAPADEP---------EP--ESAAAQSQENQDT
RPKVK--------------------A---------------------------------K
KARKVKHLDGEEDGS---------------SDQSQASGTTGGRRVSKALMASMARRASRG
PIAFWARRAS----RTRLA----A------------------------------------
------------------------------------WARRALL----SLRSPKARRGKAR
RRA---------------------------------------------------------
-AKLQS-SQEPEAPP-PRDVALL---QGRANDLVK------YLLAKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LKDIIKEYTDVYPEIIERAGYSLEKVFGIQLKEIDKNDHLYI-LLSTLEP
TDAGIL-GTTKDS-PKLG---LLM----------VLLSI----------IF--------M
-NGNR----S-S--EAVIWEVLRKLGLR--PGIHHSLFGDVKKLITDEFVKQK-------
---------YLDYARVPNSNP---P--EYEFFWGLRSYYETSKMKVLKFACKVQKK---D
------PKEWAAQYREAMEADLKAAAEAAA--EAKAR----AEIRARMGIGLGSE-----
----NAAGP--CNWD-------------EADIGPWA-KARIQAGAEAKAKAQESG--SAS
TGASTST------NNSA--SA--SAST--SGGFSAGASLTATLTFGLFAGLGGAGASTSG
SSGACG-FSYK-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------

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------------------------------------------------------------
--------------------------------------MSLEQ-----------------
-----------------RSL-HYKPE-E----------------ALEA----QQE-ALG-
-------------LVCVQA-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---AASSSSPLV----LGT--LEE------------------------------------
---------VP--------------------------------------TAGS---TDPP
QTPQGAST---FPTTIN-F--PRWRQPNE----------------SSSS--HEEEGP---
------------S------TSCVL---------------ESLFRAVLTKKVADLV-----
-------RFLLLKYRAREPVT-KAEIL--ERVIKNYK-----HCFPVIFGKASES-----
----LQLVFGID---------VKE-ADSTG---------HSYV-----------------
-------L----------------------------------VTCLGL-SYD----GLLG
---DN-QIMPKTGFL-------IIILVMIAMEGGR------APEE---EIWEELNVM---
-----EVY-DGR----EHSAYGEPRKLLTQDLVQE------NYLEYRQV-PYSDPACYEF
----LWGPRALAETS--YVKVLEYVIKVSARVRF----F-FPSLREA---ALREDEE--G
V-----------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
--------------------------------------MPRGHK---SKLRAREKR-RQN
-KT-----ENQDV-----------------------------------------------
-KS-------------AQAPAGEE------------------------------------
-----------------------------------------------------------G
-EAA-------------------------CSSSS-----I---------------LGEGP
STST-G-------------------------AGT----------------LQAPQG---A
P--ATTSAAA--------------------------------------------------
------------------------------------------------------------
----------------GAS----CERSAIKA---------------KC-H-VRKSKN---
------------------------------F-SQISTSTEIDGLDLISKKATLLV-----
-------EYLLYQYKVNEPIK-KGDML--KIIHKWYR-----KDFPEILKKVSEH-----
----MDMVYGLE---------LKE-VKPNS---------NYYT-----------------
-------L----------------------------------VDSQDD-TSN----GNLG
----SGFRFPNKGIL-------MPLLAVIFLNGNR------TPEE---EIWKFLNMM---
-----SVY-DGK----SHFIFGEPRKLITQDLVQE------KYLVYQPV-PNSHPPRYEF
----LWGPRAYAETT--KMKVLEFLAKLNDTMPS----A-FITQYEE---ALKDEEERAH
AALQ-AAA----------------------------------------------------
-----------------------------------------------------------P
----------------------SKA------------------------------SR---
------------------------------------------------------------
------------C-----------------------------------------------
------------------SRDTS---K-RYPQPE--------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------

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------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------METQIRREG
LGCSPASNKRKKKKEDSG--HLGLQVSTMFSEDDFQST---EGAPSGLQI----------
---------QWSQDLPRVQVFRE----------QANQE---DRSPR-RTQRITRG-EV--
-----------------LWGPITQIFPTVWPADLTGVIMPLEQ-----------------
-----------------RSQ-HCKPE-E----------------GLQA----QED-NPG-
-------------LVGGAQALQAE------------------------------------
-----------------------------------------------------------E
Q-E---------------------------------------------------------
------------------------------------------------------------
---AASFSSTLN----VGT--LEE------------------------------------
---------VP--------------------------------------ATES---PSPP
QSPQGESS---SPTAMD-S--IFGSLSDE----------------GSSS--QEEEGP---
------------S------TSPDLI------------DPESFSQDILHDKIIDLV-----
-------HLLLCKYRVKGLIT-KAEML--GSVIKNYE-----DYFPEIFREASEC-----
----MQLLFGID---------VKE-VDPTS---------HSYV-----------------
-------L----------------------------------VTSLSL-SYD----GIQG
---DE-QSMPKSGLL-------IIVLGVIFMEGNC------VPEE---VMWEVLSIM---
-----GVY-AGR----EHFLFGEPKKLLTHDWVQE------KYLVYRQV-PGTDPACYEF
----LWGPRAHAETS--KMKVLEYIANANGRDPS----S-YPSLYED---ALREEEEGV-
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
---------------------------------------MDRRNDYGYRVPLFQ--G---
--------PLPPP--GSLGLP----------------------------FPPDIQTETTE
EDSV-LLMHTLL-------AATK--DSLAMDPPVVNRPKK-------------SKTKKAP
IKTI----------TKA-TPA--APPVPTAKEIATNKPKITWQALNLPVITQISQALPT-
T------------------------------------------------EVTN-------
------TQASSVTAQPKKANKMKRVTAKAAQG-SQSPTGREGGTTQLKSPLQVLKLPVIS
QNIHV---PIANESASSQAL-ITSIKPKKAS---------------KAK-----------
-------------KAA----------------NKAIASATEVSLAPPATHTA-TTQGQIT
-NETASIHTTAASIRTKKVSKARKTIA--KVINTDTE-------HIEAPNV---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------TEAAT
RQIEA--------------------S---------------------------------V
VAIRPKKPKGKKAASRSP---------N------------SVSELSEAPLATQMVTNQAL
AATLRVKRGS----RARKA----ATKAQATESQT----PNADQGAQAKMAFAQ-TNVSAL
ETQ------------VA------------AAVQALADDYLAQL----SLEPTTRTRGKRN
RK-----------------------------------------------SKHLNGDERS-
GSNYRWIPWGRRPAP-PRDVAIL---QERANKLVK------YLLVKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LRDVIQEYDEYFPEIIERASYTLEKMFRVNLKEIDKQSSLYI-LISTRES
SAG-IL-GTTKDT-PKLG---LLM----------VILSV----------IF--------M
-NGNK----A-S--EAVIWEVLRKLGLR--PGVRHSLFGEVRKLITDEFVKQK-------
---------YLEYKRVPNSRP---P--EYEFFWGLRSYHETSKMKVLKFACKVQKK---D
------PKDWAVQYREAVEMEVQAAAVAVA--EAEAR----AEARAQMGIGEEAV-----
------AGP--WNWDDMDIDCLT-REELGDNAQAWS-RFSF----EIEARAQENADASTS
VNFSRGASTRAGFSDGASISFNGAPSS--SGGFSG-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------GPGITFGVAPSTSASFSNTASISFGGTLSTSS----------------
--------------------SFS------------------S----------------AA
SISFGGASSTSTSFSSEASISFGGMPCTSASFSSGVSSSFSGPFS--TSATFSGGASSGF
GG------------------TL-STTAGFSGVLSTSTSFGSAPTTSTVFSSALSTSTGFG
GTVSTSVCFGGSPSSSGSFGGTLSTSICFGGSPCTSTGFGG----TLSTSVSFDGSSSTS
ANFGGTLSTSICFDGSPSTG-AGFGGALN----------TS-------------------
-------------------------------------------------TGFGGAMSTSA
DFGGTLSTSVCFGGSPGTSVSFGSALNTNAGFGGAVSTSTDFGG----------------
------------------------------------------------------------
-----TLSTSVC------------------------------------------------
----------------------FGGSPSTSAGFGGALNTNASFGCAVSTSASFSGAVSTS
AGFSGTPSTNPGFGGAFSTSAGFGGALSTTTDFGGTPSNSIGFGAAPSTSVSFGGAHGTS
LCFGGAPSTSLCFGSASNTNLCFGGPPSTSACFSGATSPSFCDGPSTSTGFSFGNGLSTS
AGFGGGLNTSAGFGGGLGTSAGFSGG------------------------------LSTS
SGFDGGLDTSAGFGGGPGTSTGFGGGLG----------TSAGFGGGLVTSDGFGGGLGTN
ASFGSTLGTGAGFSGGLSTSDGFGSRPNASFDRGLSTIIGFGSGSNTSTGFTGEPSTSTG
FSSGPSSIVGFSGGPSTGVGFCSGPST-SGFSGGPSTGPGFG------------------
------------------------------------------------------------
-------GGPNTGAGFGGG-PSTSAGFGSGAASLGACGFSYG

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------MPLEQ-----------------
-----------------RSQ-HCKPE-E----------------GLEA----RGE-ALG-
-------------LVGAQAPATEE------------------------------------
-----------------------------------------------------------Q
E-A---------------------------------------------------------
------------------------------------------------------------
----ASSSSTLV----EVT--LGE------------------------------------
---------VP--------------------------------------AAES---PDPP
QSPQGASS---LPTTMN-Y--PLWSQSYE----------------DSSN--QEEEGP---
------------S------TFPDL---------------ESEFQAALSRKVAKLV-----
-------HFLLLKYRAREPVT-KAEML--GSVVGNWQ-----YFFPVIFSKASDS-----
----LQLVFGIE---------LME-VDPIG---------HVYI-----------------
-------F----------------------------------ATCLGL-SYD----GLLG
---DN-QIMPKTGFL-------IIILAIIAKEGDC------APEE---KIWEELSVL---
-----EVF-EGR----EDSIFGDPKKLLTQYFVQE------NYLEYRQV-PGSDPACYEF
----LWGPRALIETS--YVKVLHHMVKISGGPRI----S-YPLLHEW---ALREGEE---
------------------------------------------------------------
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------------------------------------------

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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------QRPT----------KAF-
--------------------------------ESVQASTARKE-----------------
-----------------KAN-SS----------------------TSS----SS--ITS-
-------------FFS--------------------------------------------
------------------------------------------------------------
--T---------------------------------------------------------
---------------------------------------------------------NFS
SSTPSSSLTPLI----SGI--PEEVP----------------------------------
---------AT--------------------------------------GALS---T-CQ
GSQ-GACF----SPAAT-Q--PLLSQSGE----------------NFRSQ-EEEG-P---
------------S------ISEAPP------------DPQFLLSHELNKQVTELV-----
-------QFLCVKYVTKESTP-KAEML--RSVIREHK-----D-LPVIFSKVCEC-----
----GEVVSGIE---------VKE-VDPTS---------HSYD-----------------
-------P----------------------------------VKSLNL-SYD----KRLS
---DD-RGTPKTSLL-------ILILGMTFMEGNC------APKE---KIWEVLNMM---
-----GLY-AGQ----KDFIYGESSKLINNDLMKE------QYLDYQQ--------DYGF
----LWGPRAYAETS--KMKVLEF------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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--------------------------------------MPRGQK---SKLRAQAKR-RKA
-RS-----ENQGL-----------------------------------------------
-GT-------------AQATETQG------------------------------------
------------------------------------------------------------
EEST-------------------------PSSYT-----F---------------FESRP
QNIS-N------------------------AGILG-------T-------PMLPQG---T
P--STTNITK-A------------------------------------------------
------------------------------------------------------------
-----------------DD----S------------------------------NMD---
------------------------------S-D--EDVTEGWRKDPLNKKVVLLV-----
-------QFLIDKYQKKELIT-KADML--KYVIKKYK-----YHFNEILRRASEH-----
----MELAFGVD---------LKE-VDPIR---------HYYA-----------------
-------L----------------------------------VSKLDY-TLD----GTMG
----HEENMPKMGLL-------MIVLGVIFMKGNC------ASEE---EIWKVLNMM---
-----GVY-ADR----KHFIYGEPRKVITEDLVQL------KYLESQQV-PNSDPPCYEF
----MWGPRAHAETS--KMKILEFLARIHDTTPN----A-FPSWYEE---ALKDEEDRAQ
AR-VAARARNT-AM----------------------------------------------
----------------------------------------------------------AS
--------------------SHSRAR-----------------------ERAS-SFSHAK
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------------------------------MPR---------------------------
----------------------SKKSQ-------------------------------AR
--------------------GGDKCP-QAQGQTQS---CGGAQAIAAAEEEST--TSSL-
---------------------QCEDTTQS-LPGAESCSTSQEPQ-R-------------I
---------PTIA-----------------AAAVFSYTRSSEA-------------FDG Q
YKYRALAYEVPPFTE-TPGTDCL---TRKASLLEQ------FLLYKY-KMKQLM--MK--
------------------------------------------------------------
----EDM---LKIIHQSHHDRFAEILKRASERIELVFAVELKEVDSVVPCYN-LVSKLKL
PNNGRV-RGGRGL-PKTG---LLM----------NLLGM----------IF--------L
-KGNC----A-A--EEDIWKYLGTMRVY--AGRKHLIYGEPRKLITKDLVRLK-------
---------YLEYRQVANSDP---P--RYEFLWGPKAHLETSKMKVLEFLAKVNDA---V
------PSDFPAYYEEALRDEEEKAQGMHA-ARPDTTVKVSTPPRDMLNIII-PP-----
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--------------------------------------MSLAQ-----------------
-----------------RSP-HRKPD-E----------------DLEA----QGE-DLG-
-------------LMGAQEPTGEE------------------------------------
-----------------------------------------------------------Q
E-T---------------------------------------------------------
------------------------------------------------------------
---TSSSDSE-----------EEE------------------------------------
---------VS--------------------------------------ASGS---SSPP
QSPQGGAS---SSFSVY-Y--TLWSQFDE----------------GSSS--QEEEEP---
------------S------PSVDPA------------QLEFMFQEALKLKVAELV-----
-------HFLLHKYRVKEPVT-KAEML--ESVIKNYK-----RYFPVIFGKASEF-----
----MQVIFGTD---------VKE-VDPAG---------HSYI-----------------
-------L----------------------------------VTALGL-SCD----SMLG
---DG-HSMPKAALL-------IIILGVILTKDNC------APEE---VIWEALSVM---
-----GVY-VGK----EHIFYGEPRKLLTQDWVQE------NYLEYRQV-PGSDPAHYEF
----LWGSKAHAETS--YEKVINYLVMLNAREPI----C-YPSLYEE---VLGEEQEGV-
------------------------------------------------------------
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-----------------IS----SASVRNAT---------------SS-Q-DE-EDS---
---------------------------------RSSSSTENTYRDTLNSMTSLLE-----
-------QFLLCKYKMKQPIM-KEDML--KIIHPRYH-----HRFAEILKRASEH-----
----IEAVFAVD---------LKE-VDSTI---------HSYD-----------------
-------L----------------------------------VSKLNL----------VW
----VGRGLPKTGLL-------MTVLGVIFVKGGC------AAEE---DIWKFLHMM---
-----GVY-AGR----KPIIYGEPRKLITRDLVTM------KYLEYGHV-AHSDPPRYEF
----LWGPRAHAETS--KMKVLEFLAKVNDTVPS----A-FSSQYEE---AFHSSSQACS
FS-HPTKDE-D-------------------------------------------------
----------------------------------------------------------F-
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----------------------------------MDRRNGYGYRMPAFQCKHLNGDERS-
GINYRRIPWGRRLPP-PRDVAIL---QERANKLVK------YLLVKD-QTKIPI--KR--
------------------------------------------------------------
----SEM---LKDVIQEYDEYFPEIIERASYALEKMFRVNLKEIDKQSSLYI-LISTQES
SAG-IL-GTTKDT-PKLG---LLM----------VILSV----------IF--------M
-NGNK----A-S--EGE-WLVMK----P--NGVRHSLFGEVRKLITDEFVKQK-------
---------YLEYKRVPNSRP---P--EYEFFWGLRSYHETSKMKVLKFACKVQKK---D
------PKDWAAQYREAVEMEVQAAAVAVA--EAEAR----AEARAQMGIGEEPR-----
------YRLG-----IFVHTAV--------------------------------------
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--------------------------------------MPLEQ-----------------
-----------------RSQ-HCKPE-E----------------GLEA----QGE-ALG-
-------------LVGAQAPATEE------------------------------------
-----------------------------------------------------------Q
E-T---------------------------------------------------------
------------------------------------------------------------
----ASSSSTLV----EVT--LRE------------------------------------
---------VP--------------------------------------AAES---PSPP
HSPQGAST---LPTTIN-Y--TLWSQSDE----------------GSSN--EEQEGP---
------------S------TFPDL---------------ETSFQVALSRKMAELV-----
-------HFLLLKYRAREPFT-KAEML--GSVIRNFQ-----DFFPVIFSKASEY-----
----LQLVFGIE---------VVE-VVRIG---------HLYI-----------------
-------L----------------------------------VTCLGL-SYD----GLLG
---DN-QIVPKTGLL-------IIVLAIIAKEGDC------APEE---KIWEELSVL---
-----EAS-DGR----EDSVFAHPRKLLTQDLVQE------NYLEYRQV-PGSDPACYEF
----LWGPRALVETS--YVKVLHHLLKISGGPHI----S-YPPLHEW---AFREGEE---
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--------------------------------------MPRGQK---SKLRAREKR-HQA
-RC-----ENQDL-----------------------------------------------
-GA-------------TQATVAE-------------------------------------
------------------------------------------------------------
GESP-------------------------SSAYL-----L---------------FGDRP
QNLP-A------------------------AETPS-------I-------PEALQG---A
P--STTNAIA-P------------------------------------------------
------------------------------------------------------------
-----------------VS----CS-SNEGA---------------SS-Q-DE-KSL---
------------------------------G-S--SREAEGWKENPLNKKVVSLV-----
-------HFLLQKYETKEPIT-KGDMI--KFVIRKDK-----CHFNEILKRASEH-----
----MELALGVD---------LKE-VDPIR---------HYYA-----------------
-------F----------------------------------FSKLDL-TYN----ETTS
----DEEKIPKTGLL-------MIALGVIFLNGNR------APEE---AVWEIMNMM---
-----GVY-ADR----KHFLYGDPRKVMTKDLVQL------KYLEYQQV-PNSDPPRYEF
----LWGPRAHAETS--KMKVLEFVAKMHDTVPS----A-FPSCYEE---ALRDEEQRTQ
AR-AAARAHTA-AM----------------------------------------------
----------------------------------------------------------AN
--------------------ARS--R-----------------------TTSS-SFSHAK
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-RAP-A-------------------------AGD----------------MLPKPR---S
R--------------------------------------------------GRPSS----
-------QAD----------------------------RDGG--RG--------------
GDSRAARSAVAEE----------APSTSRGA---------------GGSQ-D--------
------------------PRRSSSQGG--RP-ADAPLAVGPRSQKQLELKVAELV-----
-------QFLLIKDQRKIPIK-RADIV--KHVLGDYR-----DLFPDLLHRAAER-----
----LQYVFGYR---------LVE-LEPKS---------NTYI-----------------
-------L----------------------------------INSLEPVEED----AELR
----GDQGTPTTGLL-------MIVLGLIFMKGNA------VKET---EVWDFLRRL---
-----GVY-PTK----KHLIFGDPKKLLTEDFVRQ------RYLEYRRI-PHTDPVDYEL
----QWGPRTHLETS--KMKVLKFVAKVHNQDPK----D-WPAQYCE---ALAEEEDRAR
PQAS-APSQAS-------------------------------------------------
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------------------MSQ--LSTNLGDSSPPE-SPVPA-------------------
----------VHSRPTVLMRAP-----PASSRAPPVPWDPPPVDLQA-PMAAWQAPQPAW
EASEGQLSAPV---AXLAQPPTLGAPMVQAPSLGGAMAKPPT------------------
---------------PGVLMVHQ-PPPGAQMAQSSTPGVLMLHPSVQGGSLG--------
--AHPP-------------------------PPGTPMTH---------------------
-----P-PGTSMAHPPPPPP-----------PPPPPGTPM----T-------HPPPPGTP
------------------------MAH---PPPGNPMTHPPPPGNPMVQPLPPGTPMVHG
GPHGTP--MP-------------------HAPIAATPIAQQ---PTPGVLMAQQLTPGVL
MVQPP-------------APGAQMVQPP---PQTALM-------------------TQSP
ASITPMAKPSGPGVVMIHPPGARGPIIQTPVSG---------------APMAQTVLP---
----PGQPLATWAPQGQPLILQIQSQVI----R-------APQQV---P-----------
-------S---VPQTPQVQLATPPGWQATTPNWQVTPQGWPTTPLTWQATQVTWQAPT--
----------IAWQAAPPV-RQGPQPIRP-------------GPPPIRPGPPP-------
------------------------------------------------VLRQIPPVIRQI
-PT---------V-----------------------------------------------
--------MRQAPPLIRQA-PPPI------------------------------------
-----------------------------------------------------------R
--------------PAPHGIAGQPQLWQVLPPPP-----P---------------LRQAP
QARLLLPRVPG------------A-QVPTAPPVAQ-------IHLVPQSGPRVPQT---V
L--PAQLSIP----------------------------------------IPVP------
-------QVAPQSAP-------RAVH--CPSIIWQAPKGQAPVPQEL----PV---PQEL
PVPQDLPVSEELPVPQE-------------------------------------------
--------------------------------------LPVPQELQMPQELPVPQELQVQ
-QELQVPEGLQVPLEFQEVQQ-AQ-AM--GWRAPKVP-----THFWQSVPAQDTQEQ---
----PTQITHVE-----QQQPFQGAAASPKALQTQL-PTHQAQTT--GLQAELPSVQVQP
SWQGPPPILQAHPGTSATLTNFPRGSSRSRMT-PSGEPGPSSLEPRGPP-RE----RRAP
AK--DKKGPPKERM----------IIGATFCAPRG----APASKAYLPTAWKNLPASSET
FPATSRVF-PST----SHFQPASTDAFRGPSATSE----SPKSLPFAL---QDPYACVEA
LPAVPWVPYPDGNSSSACKAVPTILM-VTAAAPQ----A-SATD-AE---ASKS-SEPPR
RS-----------------------GKA--------------------------------
--TRK-----KKHLEPKE-DNCGHSMP-------------------------------SR
--D-RRGP----RSWENPS--QNDW--EIQRAMQ-L--LGDRESLYTPQGLNDWGYPNTS
-RM---------------PSS---LDGP------------STSR-D--------------
---------QGFC---------------GGSGGSQTWMASEVP------P------S---
VSRGSSTAQEDPDRE-TQPLSPL---DERANALVQ------FLLVKD-QAKVPV--QL--
------------------------------------------------------------
----SEM---VNVVIREYKDDSLDIINRANTKLECTFGCQLKEVDAKTHTYI-IVNKMAY
PQCNLL-ASYLER-PKFS---LLM----------VVLSL----------IF--------M
-KGYC----I-R--ENLLFSFLFQLGLD--VQETSSLFRITKKLITSVFVRHR-------
---------YLEYRQIPFTEP---A--EYELLWGPRAFLETNRVHILRFLAALYEN---Q
------PQIWSCQYLDSLAELEYKDAN----DEESHDSDDDS-------HDP--------
---TSSPHPH--------------------------------------------------
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--------------------------------------MPRGQK---SKHRAREKR-RQA
-RE-----EPTPS-----------------------------------------------
-TS-------------LH------------------------------------------
------------------------------------------------------------
-------------------------------------------------------SLDNP
EDS---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------NEDP---------------TS-Q-VE-EML---
-----------------------------K---DLQLTTKDYQEDSVDERVAILV-----
-------HYLLYKYQIKEPVT-KVEIL--KNVSQISK-----NQFVEVLKKASEH-----
----LELIFGLD---------VKE-VDPYK---------NIYV-----------------
-------L----------------------------------VNKLDL-DQV----AEVD
----DHGSVPTTGLL-------MTILGVIFTKGNR------ATEE---QIWEVLNMM---
-----GIY-AGS----LHFFFGDAKKLITKDLVKE------KYLQYQQV-PNSNPPRYEF
----TWGPRAHAETS--KMEVLEFLAKIHNCPPS----V-FTACYAE---ALKDQEERAQ
AR-AASRARLA-AV----------------------------------------------
----------------------------------------------------------AN
--------------------LRS--R-----------------------VSSS-S-----
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--------------------------------------MPRS-Q----------------
-----------------KSR-LCKLE-K----------------ILQA----QRE-AQG-
-------------LVGAQVPAPKE------------------------------------
-----------------------------------------------------------K
K--A--------------------------------------------------------
------------------------------------------------------------
--SSSCSTTPLV----QGT--SKEV---P---------------------PAG-------
----------I--------------------------------------PNTP-------
ESPQRACS---SSTAIA-A--TPLSKSGV----------------G-ASS-Q--------
---------------VGPSTSQAPP------------DTESSLTNVLEEKVADLV-----
-------RFLSCKYITKEPIT-KADIL--KSIIKEYK-----DHFPMIFKKASEC-----
----MQVVFGID---------VKE-ADPSG---------HSYM-----------------
-------L----------------------------------INTLDL-TYS----GMLS
---D-ERGMPKTGLL-------ILILGVIFMEGNC------ATEE---KMWEVLHTI---
-----GVY-AGR----KDFIYGEPRKLITRDLVQE------KYLEYRQV-AGSNPPCYEF
----LWGPRAYAETS--KMKVLEFFTKVSGTDPT----D-FPTLYEE---ALRDEKERAQ
ARSATTDETTA-------------------------------------------------
------------------------------------------------------------
-----------------------TA--------S----------------ESS----SA-
------------------------------------------------------------
---------TSS---------------------TF-------------------------
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--------------------------------------MPRP-R----------------
-----------------KRR-RCMVE-E----------------EPEA----Q-S-AP--
------------------VSIE-E------------------------------------
------------------------------------------------------------
V-DS-----------------------SSSSTCSSSFPSSFCSS----------------
-----------------------------------------------------------S
------SYYALT----SST--SEEG--L--------------------------------
----------A--------------------------------------ASRT---PSPS
HSPPRAGS---SCTAMI-S--SPCSQLS-------------------TDS-ETEESL---
------------G------SSEALP------------CAASLSKGEIDVKVDELV-----
-------KYLLFKYLMKEPVT-KAEML--NNIIRNYQ-----DHFPVIFREASEC-----
----MQLVFGID---------MKE-VE PAG---------HTYI-----------------
-------L----------------------------------VIALEL-TYD----GMMT
---DI-QGIP KTGLL-------IMVLSIIFMEGNC------ISED---MVWDVLNNI---
-----GLY-AGN----NHFIYGEPRKLITDDFVQE------GYLEYRQV-SGSHPPSYEL
----LWGPRAYAETT--KMKILMFLTSINGSDPR----S-YPIWYAE---ALRDEEERA-
------------------------------------------------------------
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---------------------------------------MAQKMDCGAGLLGFQSPNA--
--CRAVCHPLPQPPASTLPLSAFPT-QCDPPYSQLRDPPPVLSCCCMPLRASLAPAEASV
EDSA-LLMQTLM-------EAIQ--IS-EAPPTNQA--TA--------------------
------------------------------------------A-----ASPQSSQPPTA-
N------------------------------------------------EMAD-------
------IQVSAAAARPKS------------------------------------------
-----------------------------AF---------------KVQ-----------
-------------NAT----------------TKGPNGVYDFSQAHNAKDVP-NTQPKAA
F-------------------KSQNATP--KGPNAAYD-------FSQAATT---------
----GELAANKSEMAFKAQNAT-TKVGPNA---------T-YNFSQSLNANDLANSRPKT
------------------------------------------------------------
----------------------------------------------PFKAWNDTTKSPTA
-------------------------------DTQT-----------QNI-----------
----NQA---KMATSQ--------ADIETD--PG---------ISEPDGATAQTSADGSQ
AQNLE--------------------S---------------------------------R
TIIRGKRTRKINNLNV---------EENSSGDQRRAPLAAGTWRSAPVPVTT-QNPPGAP
PNVLWQTPLA----WQNPS----GWQNQTARQTP----P-ARQSPPARQTPPAWQNPVAW
QNPVIWPNPVIWQNPVIWPNPI-VWPGPVVWPNPLAWQNPPGWQTPPGWQTPPGWQGPPD
WQG---PPEWPLPPDW-PLPP-DWPLP-TDWPLPPDWIPADWPIPPDWQNLRPSPNLRP-
-SPNSRASQNPGAAQ-PRDVALL---QERANKLVK------YLMLKD-YTKVPI--KR--
------------------------------------------------------------
----SEM---LRDIIREYTDVYPEIIERACFVLEKKFGIQLKEIDKEEHLYI-LISTPE-
SLAGIL-GTTKDT-PKLG---LLL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPLLGDLRKLLTYEFVKQK-------
---------YLDYRRVPNSNP---P--EYEFLWGLRSYHETSKMKVLRFIAEVQKR---D
------PRDWTAQFMEAADEALDALDAAAA--EAEAR----AEARTRMGIGDEAV-----
------SGP--WSWDDIEFELLT-WDEEGDFGDPWS-RIPF----TFWARYHQNARSRFP
QTFAG---------------------P--IIGPGGTASA------NFAANFGAIGF----
--------FWVE------------------------------------------------
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-----------------------------MPRRQKNPQHS-------YDQQ------LQT
-FT-----KSQDL-----------------------------------------------
-EV-------------AQVSRALE------------------------------------
-----------------------------------------------------------E
-T-H-------------------------LSSHP-----L---------------MPGNL
KEAA-G------------------------TSVSG-------F-------PESPQS---F
Y--ASATAFT-P------------------------------------------------
------------------------------------------------------------
-----------------TS----SSKSDEGF---------------TS-P-GKEHSS---
-----------------------------GT-SQAVPDPQNVPIDALNKDVALVV-----
-------NFLLLKYQMKEPIT-EEEML--KI-VNNCQ-----VHFPEILMRASEH-----
----MEIIFGLD---------LKE-VDPAN---------HRYD-----------------
-------L----------------------------------LIKLGL-TYD----GMLP
----GEVGVPKTGFL-------LLILGVIFMKGNR------ATEA---EIWEVLNAT---
-----GIY-SGR----KHFIFGEPRKLITKDFVKE------KYLEYRQV-ADTDPAQFEF
----LWGPRAHAETT--KMKVLEFLAKVHGTDAS----S-FPSQYEE---ALQDEEEKAR
AR-IPGRAVSP-SL----------------------------------------------
----------------------------------------------------------AT
--------------------ASS--G-----------------------VKTG-SFFHT-
------------------------------------------------------------
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--------------------------------------MPRRHK---NKSHAHGKC-HQV
-RG-----DTQEA-----------------------------------------------
-QA-------------SAAAAPEE------------------------------------
-----------------------------------------------------------E
-CP--------------------------SSPSS-----A---------------PHGSP
LSSP-A-------------------------AGD----------------RQELQG---A
M--APSSADA-G------------------------------------------------
------------------------------------------------------------
-----------------PS----CAGSDEGA---------------QG-P-EE-ESA---
-----------------------------GA-SQAAPATQSTRKDPLARKARILV-----
-------EFLLEKYTKKEAIT-QNALM--KIVSRKYR-----QHFPEILSTARER-----
----VEVVFGLE---------MKE-VDRSR---------NIYT-----------------
-------L----------------------------------ISKLNL-GGN---DCP-S
----AEGALPKSGLL-------MVLLGVIFMNGNR------ATEE---EIWEFLSML---
-----GIY-AGR----RHWIFGEPRRLITKDLVQK------EYLNYRQV-PNSDPPRYEF
----LWGPRACADTS--KMKVLEGLAKFHGRVPS----S-FPDVYDE---ALRDQTERAG
LR-GAARAPTM-AE----------------------------------------------
----------------------------------------------------------AS
--------------------APS--K-----------------------AKSC-TSSHI-
------------------------------------------------------------
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-----------------------------------------------------MSEQSKD
VCD---------------------------------------------------------
------------------------------------------------------------
--------LVS----------------------------A---------------AEA-S
NSEA--------------------------HRS-----------------PGGPGE---P
S--PSASQAAT----------LAGPERRPSGP------------T---------------
----DGSLAS--------------------------------------------------
------PPP--------------QASSEEGD---------PKAL-QQA-T-EE--GR---
----------------------AHQAP----TAAQPA-PAPPAPAQLVQKAHELM-----
-------WYVLVKDQKRMIIW-FPDMV--KDVIGSYK-----KWCRSILRRTSLI-----
----LARVFGLH---------LRL-TSLHT---------MEFS-----------------
-------L----------------------------------VKALEPEELD-----RVA
----LSNRMPMTGLL-------LMILSLIYVKGRG------ARES---AVWNVLRIL---
-----GLR-PWK----KHSTFGDVRKLITEEFVRQ------NYLKYQRV-PHVEPPEYEF
----FWGSRASREIT--KMQIMEFLARVFKKDPQ----A-WPSRYRE---ALEEARALRE
ADPTA----------------------------------YCPRSSVSED-----------
------------------------------------------------------------
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-----------------------------------------S-S----------------
-----------------D-E-EQEEE-E----------------EKEE----EEE-EEE-
-------------EEEEEEKEEEE------------------------------------
-----------------------------------------------------------E
E-EE-----------------------E--------------------------------
------------------------------------------------------------
-----------------EE--EEEVVVHA---------------------AAG-------
----------A--------------------------------------PSPP---RSS-
---PSAHA---SPTAFAAA--APLSQ---------------------SSS-EEGEGP---
------------S------TSWALP------------GTESLPRSVINDKVADLV-----
-------EFLLLKYRTKELTT-RAEML--SSIIREHQ-----DHFAVIFREASEC-----
----MQLVYGIE---------VKE-VDPTS---------HTYV-----------------
-------L----------------------------------VTNLGL-TYD----GMVS
---DE-HSMPKTGLL-------ILILSIIFSEDDC------APEE---KIWEALNAM---
-----GVH-AGM----EHSIYGEPRELLTRDWVQE------QYLEYQQV-PNSDPARYEF
----LWGPRAYAETT--KLKILEFLAQVNGSDPR----S-YTHWYQK---ALREEEQRAQ
ARISTTDDTTA-------------------------------------------------
------------------------------------------------------------
-----------------------MA--------S----------------TS--------
------------------------------------------------------------
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--------------------------------------MPRGQK---SKHRAREKR-RQT
-QT-----ETQGV-----------------------------------------------
-HD--------------QATTSGG------------------------------------
-----------------------------------------------------------E
-ETT-------------------------SSSLP-----D---------------SESAP
SSSS-A-------------------------AGT----------------PKGPQG---A
H--GTTSAAAGAIRKRSGGGGA--------------------------------------
------------------------------------------------------------
------------------A----RSRSGVGA---------------EG-Q-VQEGE----
-----------------------------NS-SQASAAAESSHTDILTRKAELLV-----
-------PYMLYKYKMRELIK-RSEIL--KEINRRYK-----EQYPEILRRASEH-----
----MEMVFGLV---------LKE-IRPNS---------HCYT-----------------
-------L----------------------------------VSNLDL-SDS----ESMR
----GDWGLPKNGLL-------MPLLGVIYLNGNH------APEE---KIWKFLNML---
-----GIY-DGR----SHFIFGEPRKLITEDLVRE------EYLEYRQV-PGSDPPRYEF
----LWGPKALTEMS--KTKVLQFLAKVKDSVHP----A-FLLQYEE---AWREEVETTG
ARSEA-RA-------------G---TSASTRPG---------------------------
-----------------------TAA----------------------------------
-S--------------------AA------------------------------ACSSAS
TRP-----------------G-TA------------------------------------
---------------A--------------------------------------------
------------------------------------------------------------
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---------------------M-------SLVSQNARH----------------------
------------------------------------------------------------
------------------GSAETT------------------------------------
-----------------------------------------------------------A
-DY---------------------------------------------------------
-----------------------------------------------------------S
D--GRGEMQA----------------TNASGP------------S-T-------------
---------------------------------------------------SM------L
----------VPEAPQ----GPQIPIDPQGA---------------SAPQ-AA-------
---------QDP----N--DIEV--LID-EQSRRLGA---LRVHDPLEERSVALV-----
-------NFMRMKSQSEGSIR--QSDM--LEFLREYS-----DQFPEILRRASAH-----
----LDRVFGMN---------LRV-LDPQT---------DTYN-----------------
----------------------L-------------------VSKPGP-QST----ERLA
----ETLDMPKAGLL-------ALVLGHILLNGNR------AREA---SIWDLLLKV---
-----DVM---DEPQRINNLFGNTRSLLTTDFVRM------RFLEYWPV-YGTNPLEFEF
----LWGSRAHR--EITKM-----------------------------------------
------------------------------------------------------------
--------------------------E-------------------------------AL
K-----------------------F---VA----------------EAHDEEP-------
------------------------WSWPE-EYN------------KALEADKAKEK---S
---------------------------------------------------------QA-
AG---L--------E-FWSED---AMNDKANDLVQ------LAINVT-EELLPI--HQ--
------------------------------------------------------------
----DEL---LAHTGKEFEDVFPNILSRATLILDLFYGFSLIEVDTSEHIYL-LVQQPES
EEEQVM-LESLGR-PTQE---YVM----------PILGL----------IF--------L
-MGNR----V-K--EANIWNLLRRFSVD--VGRKHAI--------TCKLMRQR-------
---------YLECRPLSYSNP---V--EYELLWGPRAHLEITKMKALEYMARLYRK---R
------PQDWPEQYREAVE-----------EEEARARSEGTATFF----FGS--------
---M--------------------------------------------------------
------------------------------------------------------------
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------------------------------------------

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------------------------------------------------------------
--------------------------------------MLLRQ-----------------
-----------------KRQ-SCKAE-E----------------GRQA----QGD-APG-
-------------LMDVQIPTTEE------------------------------------
-----------------------------------------------------------Q
K-A---------------------------------------------------------
------------------------------------------------------------
----ASSSSTLI----AGT--LEE------------------------------------
---------VP--------------------------------------DSGS---LSPA
QSPRGASS---SLTVTD-D--TLWSQSNE----------------VSSS--NEEEGP---
------------S------TSPDPA------------HLESLFREALDEKVAELV-----
-------HFLLRKYQIKEPVT-KAEML--ESVIKNYK-----NHFPEIFSKASEC-----
----MQVIFGID---------VKE-VDPAG---------HCYV-----------------
-------L----------------------------------VTCLGL-SYD----GLLG
---DD-QSTPKTGLL-------IIVLGMILMEGSC------APEE---AIWEALSVM---
-----GLY-DGR----EHSAYWELRKLLTQDWVQE------NYLEYHQV-PGSDPVRYEF
----LWGPRALAETS--YVKVLEHVARVNARVRI----S-YPSQSNR---CEATGESGGV
YMP---------------------------------------------------------
------------------------------------------------------------
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-----------------TS----------------------------SSSSSSSSSSSSS
SSSSSSSSS------SSTSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS
SSSSSS---------------------------------------S----------SSSS
SSSSSSSPHPTS----SSCFVTQGTIIEV-------------------------------
-----PGTA------------------------------------------GT---PSPS
QASQRVWT---LPTALA-T--TPSIISDQ----------------ESGST--KRKRP---
------------S------TSQAQP------------DGGYLLRDAIDDKVGDLL-----
-------KFLLLRYHRKEVAT-KAEML--SVI-KDYQ-----DLFPMILSQATYC-----
----MTLVFGID---------VKA-LDPTG---------LVYV-----------------
-------L----------------------------------VNTLGL-TYN----DSL-
RG-DE-ESMPMAGLL-------VNTLSIIFIDGNC------TSEE---KIWEMLGIV---
-----GLY-AGM----NHSIYGDPRELLTQVWVQH------GYLEYRQV-PNSDPACYEF
----LWGPRTYAETT--KMKVLEFLAKVHDTTPS----A-FPSLYEE---ALQSEKPGPQ
ATVVARA-----------------------------------------------------
------------------------------------------------------------
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--------------------------------------------------MLQKPR---G
R--------------------------------------------------GRPST----
-------QAD----------------------------PERDWGGA--------------
----------GEE----------GPSTSRAA---------------GGSS-Q--------
------------------GSR---------A-SLSAPTVGPRTQKQLELKVAELV-----
-------QFLLIKDQKKIPIK-RTDIL--KHVVGDYR-----DVYPNLLKLAAER-----
----LQYVFGYK---------LVE-LEPKS---------HSYI-----------------
-------L----------------------------------INMLEPVEAD----AEMR
----GDQGTPISGLL-------MIVLGLIFMKGNT------ITET---EVWDFLRRL---
-----GVY-PTK----KHLIFGDPKKLITEDFVRQ------RYLEYRRI-PHTDPVDYEL
----QWGPRTNLETS--KMKVLKFVAKVHNQDPK----D-WPTQYCE---ALADEESRAR
PATA-SAPATSS------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
---------------------------------------MSDT-----------------
---------------SE-SGA----------------------------DLTRFQAEASE
EDSS-LVMQTLL-------AVTQ--NLEVSEAPKAS------------------KT----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------PGVSQRLKVS-------NAPGGS---------------KAI-----------
-------------EV---------------------SKATVVSKAQEAQEAA-VTHTSPT
-PQLTDTQVLVA----EN--NSPAADT--KMQNADLQ-------GVPMPAT---------
----KTKK-----VSC--------------------------------------------
------------------------------------------------------------
--------------------------------------------------------VA--
-------------------------------NTQV-------------------------
----S-T--KSLETEV--------AASQAPTDEP---------EP--KGTATETQENQDT
RPKVK--------------------A---------------------------------K
KARKVKHLNGEEDGS---------------SDQSQTSGNTGGRRVSKALMASMARRASRG
PIAFWARRAS----RTRLA----A------------------------------------
------------------------------------WARRALL----SLRSPKARRGKVR
RRA---------------------------------------------------------
-AKLQS-SQEPEAPP-PRDVALL---QGRANDLVK------YLLVKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LKDIIKEYTDVYPEIIERAGYSLEKVFGIQLKEIDKNDHLYI-LLSTLEP
TDAGIL-GTTKDS-PKLG---LLM----------VLLSI----------IF--------M
-NGNR----S-S--EAVIWEVLRKLGLR--PGVHHSLFGDVKKLITDEFVKQK-------
---------YLDYTRVPNSNP---P--EYEFFWGLRSYYETSKMKVLKFACKVQKK---D
------PKEWAAQYREAMEADLKAAAEAAT--EAKAR----AEIRAQMGIGLGSE-----
----NAAGP--CNWD-------------EADIGPWA-KARIQAGAEAKAKARESG--GTS
EGANTS--------------------A--SSGFNASSSLTATLTFGLFAGLSGAGTSTNG
SSGACG-FSYK-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------MPR---------------------------
----------------------GNKSK---------------------------------
-SR-----------------SRAKRQ-QMRGERAN---LQGAQPTVEE-EK------AA-
-SP-------------------ALV-QGD-APSSPNTGTAQ----E-------------A
---------ASHS---A-------------PELNVSHPAREVG---------AEG SFADV
DERRTNVSTIADAIQ-SARRDPL---TRKATKLLH------YLLEKY-QKDE QP--VQ--
------------------------------------------------------------
----AEM---LKLISRKYKGHFPRILEKATYQLELVYGLELKVDNPTTCSYA-LVSKLPI
RPGANV-GGKREL-PKTG---LIL----------TLLGM----------IF--------M
-KDNH----A-T--EEEVWQFLHMQGIY--PGRRHLIFGEPRNFITKELVDQN-------
---------YVEYRQVPGSDP---P--TYEFLWGPRAHEEHTSRKVMEILTKIKNA---I
------PTYYPRQYEEALSNQDESAARRDE-AVGFHAA---RIPS----HAQPSSSSHI-
------------------------------------------------------------
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------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------M-------SLVSQNARR----------------------
------------------------------------------------------------
------------------CSAEIT------------------------------------
-----------------------------------------------------------A
-DY---------------------------------------------------------
-----------------------------------------------------------G
D--GRGEIQA----------------TNASGS------------P-T-------------
---------------------------------------------------SM------L
----------VVDAPQ----CPQTPINSQCV---------------NTSQ-AV-------
---------QDP----N--DLEV--LID-EQSRRLGA---LRVHDPLEDRSIALV-----
-------NFMRMKSQKEGSIQ--QSEM--LEFLREYS-----DQFPEILRRASAH-----
----LDQVFGLN---------LRV-IDPQA---------DTYN-----------------
----------------------L-------------------VSKRGF-QIT----DRIA
----ESLDMPKASLL-------ALVLGHILLNGNR------AREA---SIWDLLLKV---
-----DMW---DKPQRINNLFGNTRNLLTTDFVCM------RFLEYWPV-YGTNPLEFEF
----LWGSRAHR--EITKM-----------------------------------------
------------------------------------------------------------
--------------------------E-------------------------------AL
K-----------------------F---VS----------------DAHDEEP-------
------------------------WSWPE-EYK-------------ALEADKTKER---S
---------------------------------------------------------LT-
AG---L--------E-FWSED---TMNDKANDLVQ------LAISVT-EEMLPI--HQ--
------------------------------------------------------------
----DEL---LAHTGKEFEDVFPNILNRATLILDMFYGLSVIEVDTSEHIYL-LVQQPES
EEEQVM-LESLGR-PTQE---YVM----------PILGL----------IF--------L
-MGNR----V-K--EANVWNLLRRFSVD--VGRKHSI--------TRKLMRQH-------
---------YLECRPLSYSNP---V--EYELLWGPRAHHETTKMKVLEYMARLYRK---R
------PQNWPEQYREAVE-----------DEEARAKSEATIIFF----LDP--------
---T--------------------------------------------------------
------------------------------------------------------------
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------------------------------------------

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------------------------------------------------------------
------------------------------------------------------------
--------------------------------------MPRGQK---SKQRAREKR-RQA
-RG-----QQESV-----------------------------------------------
-EH-------------TQATVVEE------------------------------------
-----------------------------------------------------------E
-ESP-------------------------SFSAS-----N---------------TEDII
EEPL-A------------------------AGAPS-------N-------EQEPET---A
-----TGAAA-V------------------------------------------------
------------------------------------------------------------
-----------------VS----YARSKEGT---------------NN-P-GR-ERP---
-----------------------------SA-SQARAAMKHLQSGPLAERVAMLV-----
-------HYLLYKYQVRESVT-KADML--KNVVQMYK-----HHFPEILKKASER-----
----LELVFGLD---------IKE-VDPNR---------SIYV-----------------
-------L----------------------------------VNKLEP-NYN----ARVT
----DNRGVPKTGLL-------MIILGVIFTKGNC------ATEE---QVWEVLNMM---
-----GVY-EDS----IHFIFGDPKKLVTEDLVQD------RYLEYRQV-PDSDPPRYEL
----LWGPRSYAETS--KMRVLEFLAKIHDTVPS----A-FPDWYEE---ALQDEEERAQ
AR-VAARARIS-AL----------------------------------------------
----------------------------------------------------------AR
--------------------ARS--K-----------------------ALTS-SLPCPK
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------MPR---------------------------
----------------------SQKSK-------------------------------LQ
--------------------ASEKRR-QAQAEAQA---GENAQATAAVEKEST-PSFPP-
---------------------QYEDTAQI-LPPVRASSTSQWYR-R-------------A
---------QATT----------------FTSVGASWARSDAE-------------YNNQ
DYDRA NAYEAAYYTE-NVGEDSL---TRKPGLLEQ------FLLYKY-KMKQPI--LK--
------------------------------------------------------------
----EDM---LKIIGHHYEDQFPEILKKASERIEIVFAVDLKEIDSTRQSYD-LISKLKL
PNNGRV-RAGRGL-PKTG---LLM----------NILGM----------IF--------M
-KGNC----A-A--EEDIWKFLGMMQVY--AGRKHFIYGEPRKLITKDLVRLQ-------
---------YLEYRQVSNSDP---P--RYELLWGPKAQAETSKMQVLEFLAKVNDT---I
------PSAFPSYYEEALRDEEARASAI---------AKVIASSRAMPWNIFPPLVKPEL
------YTPY-S------KYISG-STKA--------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------MSEQSKD
LSD---------------------------------------------------------
------------------------------------------------------------
--------PNF----------------------------A---------------AEA-P
NSEV--------------------------HSS-----------------PGVSEG---V
P--PS-----AT---------LAEPQSPPLGP------------T---------------
----AAPQAA--------------------------------------------------
------PPP--------------QAPNDEGD---------PKAL-QQA-A-EE--GR---
----------------------AHQAP----SAAQPG-PAPPAPAQLVQKAHELM-----
-------WYVLVKDQKKMIIW-FPDMV--KDVIGSYK-----KWCRSILRRTSLI-----
----LARVFGLH---------LRL-TSLHT---------MEFA-----------------
-------L----------------------------------VKALEPEELD-----RVA
----LSNRMPMTGLL-------LMILSLIYVKGRG------ARES---AVWNVLRIL---
-----GLR-PWK----KHSTFGDVRKLITEEFVQM------NYLKYQRV-PYVEPPEYEF
----FWGSRASREIT--KMQIMEFLARVFKKDPQ----A-WPSRYRE---ALEEARALRE
ANPTA----------------------------------HYPRSSVSED-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------

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------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MAQNMDRGAGLLGFQRPDA--
--CKAGCCPLPQPPTSTLPLSVFPTC-CGSASAQLLALPRILSVHPV---PFLNPAEASV
EDNT-LLMQTLM-------EAIQ--IS-EAPPTNQA--TA--------------------
------------------------------------------AASGPNASPQSSQPPTA-
N------------------------------------------------EMAD-------
------NQVSTAAARPKT------------------------------------------
-----------------------------AF---------------KGQ-----------
-------------KAT----------------TKGPNGVYDFSQAPNAKEKP-NAQPKAG
F-------------------KSQSAAP--KGASAAYD-------FSQAAAT---------
----EELVAGKSEMAFKAQNGT-TKVGPNA---------T-YNFSQSFSANEMANNRPKT
------------------------------------------------------------
----------------------------------------------AFKAWNDTTKAPTA
-------------------------------DSQT-----------QNV-----------
----NQT---KMATSP--------EDIENN--PG---------VAEPDVAAAQTSADGPQ
AQN-E--------------------S---------------------------------R
TIIRGKRTRKXXXXXX---------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXX----XXXXX----XXXXXXXXXXX----XXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXX---XXXXXXXXXX-XX---XXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-
-XXXXXXXXXXXXXX-XXXXXXX---XXXANKLVK------YLMLKD-YTKVPI--KR--
------------------------------------------------------------
----SEM---LRDIIREYTDVYPEIIERACFVLEKKFGIQLKE-DKDEHLYI-LISTPE-
SLAGIL-GTTKDT-PKLG---LLL----------VILGV----------IF--------M
-NGNR----A-T--EAVLWEALRKMGLR--PGVRHPLLGDLRKLLTYEFVKQK-------
---------YLDYRRVPNSNP---P--EYEFLWGLRSYHETSKMKVLRFIAE--------
------------------------------------------------------------
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------------------------------------------

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------------------------------------------------------------
-----------------------------------------------------LVQQPES
EEEQVM-LESLGR-PTQE---YVM----------PILGL----------IF--------L
-MGNR----V-K--ESNVWNLLRRFSVD--VGRKHAI--------TCKLMRQR-------
---------YLECRPLSYSNP---V--EYELLWGPRAHLETTKMKALEYMARLYRK---R
------PQDWPEQYREAVE-----------DEEARARSEATAMFF----FGA--------
---M--------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------MSEQSKD
LSD---------------------------------------------------------
------------------------------------------------------------
--------PNF----------------------------A---------------AEA-P
SSEV--------------------------HSS-----------------PGVPEG---V
P--PS-----ET---------LAEPQSPPLGP------------T---------------
----AAPQAA--------------------------------------------------
------QPP--------------QAPSDEDD---------PKAL-QQA-A-EE--GR---
----------------------AHQAP----SAAQPG-PAPPAPAQLVQKAHELM-----
-------WYVLVKDQKKMIIW-FPDMV--KDVIGSYK-----KWCRSILRRTSLI-----
----LARVFGLH---------LRL-TSLHT---------MEFA-----------------
-------L----------------------------------VKALEPEELD-----RVA
----LSNRMPMTGLL-------LMILSLIYVKGRG------ARES---AVWNVLRIL---
-----GLR-PWK----KHSTFGDVRKLITEEFVQQ------NYLKYQRV-PYVEPPEYEF
----FWGSRASREIT--KLQIMEFLARVFKKDPQ----A-WPSRYRE---ALEEARALRE
ANPAA----------------------------------HCPRSSVSED-----------
------------------------------------------------------------
------------------------------------------------------------
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--------------------------------------------------MLQKPG---S
G--------------------------------------------------GLPVP----
-------EAE----------------------------AEKDGGHDDETEALT-----A-
-SQE-------------------SPREDLGA---------------VREA-A--------
----------------AAEPALTPKSA--RA-SASKALARRRVYRLLDRRVAELV-----
-------QFLLVKDKKKSPIT-LSERV--KYVI-DLK-----DLFPEIIARAAEH-----
----LRYVFGFE---------L-Q-LDRKH---------HTYI-----------------
-------L----------------------------------INKVKPLDEE--------
-KEVLGGDGPRLGLL--------MILSLIYMKGNS------TREA---QVWEMLRRL---
-----GVH-PSK----YHLLFGYPKSLIMEDFVQQ------RYLNYSRV-PQTNPPEYEF
----SWGPRSNLEIS--KMKVLGFVAKLHKKEPH----Y-WRVQYRE---ALADEADRAR
AKAR-AEASMRVRA--------RARA------V---------------------------
------------------------------------------------------------
-MR----L------WW--------------------------------------------
------------------------------------------------------------
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--------------------------------------MLLGQ-----------------
-----------------KSQ-RYKAE-E----------------GLQA----QGE-APG-
-------------LMDVQIPTAEE------------------------------------
-----------------------------------------------------------Q
K-A---------------------------------------------------------
------------------------------------------------------------
----ASSSSTLI----MGT--LEE------------------------------------
---------VT--------------------------------------DSGS---PSPP
QSPEGASS---SLTVTD-S--TLWSQSDE----------------GSSI--NEEEGP---
------------S------TSPDPA------------HLESLFREALDEKVAELV-----
-------RFLLRKYQIKEPVT-EAEML--ESVIKNYK-----NHFPDIFSKASEC-----
----MQVIFGID---------VKE-VDPAG---------HSYI-----------------
-------L----------------------------------VTCLGL-SYD----GLLG
---DD-QSTPKTGLL-------IIVLGMILMEGSR------APEE---AIWEALSVM---
-----GLY-DGR----EHSVYWKLRKLLTQEWVQE------NYLEYRQV-PGSDPVRYEF
----LWGPRALAETS--YVKVLEHVVRVNARVRI----S-YPSLHEE-----ALGEEKGV
------------------------------------------------------------
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------------------------------------------

------------------------------------------------------------
------------------MSL--VSQNSRRRRGGRAN---AR------------------
--------------------RNNGKGHPAAVPGPDVPRDRNDPKILQ-GLRAS-------
---EG-----------------PGT------------SMLPT------------------
---------------PREGPSA---------SVPPTAS---EGS------II-SVG-PNT
SEMPTS---------------R-KG----RGASRPPAVS---------------------
-----AGLNTAMSITASEGPS------SPVPPTAPKGSKA---YE-------HLAVSEGL
AI----------------------SE-QRHSDGGP--NMEPIL--------AEGPGISVP
PTFSEESGIS-------------------VPLPSDEGLSIF-------MS--PNISEGPG
IHEPYSVSEDPS--------TS---VP-----PTDSNG------------LG---INLPP
T------FGEGLSISMLFSALEEPDIFAPPPSA---------------EGLFTS------
------------------------------------------------------------
------------------------------------------MSPPSGEIQSSWVSPIIM
EGCNVNV---------PPTSKKGLRTSVP---------------SAACESPST-------
------------------------------------S---------------AEGLSSSL
----------SSI----------------------------------------------S
AEGFCSS---------LAP-----------------------------------------
------------------------------------------------------------
---C------------------------AAEG--SCELLP---------------CGEGR
STSE---LHCL------GEGSS-TSQMSLAAEGPSA--S---G---M---PT--------
---------------------------EANNP----------------------------
------EEALSCCA------SER--RNKSTSRALQK------------------------
-----------------------AKDPSVRP---------------K-------------
-------REDRFLDFQVLRDSKNSNSITIMGLGTSRVALTLKPQDPMEQNVAELL-----
-------QFLLLKDQTKYPIK-ESDMR--EFIDKDYR-----HQFPEILRRAAVH-----
----LECIFRFE---------LKE-LDTEE---------HIYI-----------------
-------L----------------------------------LNKLGPVPFE-----GLE
----DVPNGPKMGLL-------MMILGHILLNGNQ------AREA---DIWEMLWRF---
-----GVQ-RER----RLSVFGNVKRLLSVEFVWQ------RYLDYRPL-TDCVPVEYEF
----YWGPRSRAETT--KMKILKFMAKIYNKDPM----D-WPALYNE---ALEEDADRVV
VNN---------------------------------------------------------
------------------------------------------------------------
----FRVARPFRRPLFAE----------VAPE------------------LDA-S-----
------------------------------------------------------------
--------------------------------------G---------------------
---------SKYSPH-SWPESRL---ESKSRKLVQ------LFLLMD-STKLPI--PK--
------------------------------------------------------------
----KGI---LYYIGRECAKVFPDLLNRAARTLNHVYGTELVVLDPRNHSYT-LYNRREM
EDTEEI-MDSPNR-PGNN---FLM----------QVLSF----------IF--------I
-MGNH----A-R--ESAVWAFLRGLGVQ--NGRKHVI--------TCRYLSQR-------
---------YLDSLRVPDSDP---V--QYDFVWGPRARLETSKMKALRYVARIHRK---E
------PEDWPEQYREAMEDEANRAEAGRR-PL----------IVRNLR-----------
------------------------------------------------------------
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--------------------------------------MLLGQ-----------------
-----------------KSQ-RYKAE-E----------------GLQA----QGE-APG-
-------------LMDVQIPTAEE------------------------------------
-----------------------------------------------------------Q
K-A---------------------------------------------------------
------------------------------------------------------------
----ASSSSTLI----MGT--LEE------------------------------------
---------VT--------------------------------------DSGS---PSPP
QSPEGASS---SLTVTD-S--TLWSQSDE----------------GSSS--NEEEGP---
------------S------TSPDPA------------HLESLFREALDEKVAELV-----
-------RFLLRKYQIKEPVT-KAEML--ESVIKNYK-----NHFPDIFSKASEC-----
----MQVIFGID---------VKE-VDPAG---------HSYI-----------------
-------L----------------------------------VTCLGL-SYD----GLLG
---DD-QSTPKTGLL-------IIVLGMILMEGSR------APEE---AIWEALSVM---
-----GLY-DGR----EHSVYWKLRKLLTQEWVQE------NYLEYRQA-PGSDPVRYEF
----LWGPRALAETS--YVKVLEHVVRVNARVRI----S-YPSLHEE-----ALGEEKGV
------------------------------------------------------------
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---------------------------------------MAQKMDRGAGLLGFQA-----
--------------------------------------------------------EASV
EDSA-LLMQTLM-------EAIQ--IS-EAPPTNQA--TA--------------------
------------------------------------------A-----ASPQSSQPPTA-
N------------------------------------------------EMAD-------
------IQVSAAAARPKS------------------------------------------
-----------------------------AL---------------NVQ-----------
-------------NAT----------------TKGPNGVYDFSQAHNAKEVP-NTQPKAA
F-------------------KSQNATP--KGPNAVYD-------FSQAATT---------
----GELAATKSEMAFKAQNAT-TKVGPTA---------T-YNFSQSLNANDMANNRPKT
------------------------------------------------------------
----------------------------------------------PFKAWNDTTKAPTA
-------------------------------DTQT-----------QNV-----------
----NPA---KMATSH--------ADIETD--PV---------ISEPDGATAQTSADGSQ
AQNLE--------------------S---------------------------------R
TIIRGKRTRKINNLNV---------EENNSGDQRWAPLAAGTWRSAPVPVTT-QNPPGAP
PNVLWQTPLA----WQNPS----GWQNQTARQTP----P-ARQSPPARQTPPAWQNPVAW
QNPVIWPNPVIWQNPVIWPNPI-VWPGPVVWPNPLAWQNPPGWQTPPGWQTPPGWQGPPD
WQG---PPDWPLPPDW-PLPP-DWPLP-TDWPLPPDWIPADWPIPPDWQNLRPSPNLRP-
-SPNSRASQNPGAAQ-PRDVALL---QERANKLVK------YLMLKD-YTKVPI--KR--
------------------------------------------------------------
----SEM---LRDIIREYTDVYPEIIERACFVLEKKFGIQLKEIDKEEHLYI-LISTPE-
SLAGIL-GTTKDT-PKLG---LLL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPLLGDLRKLLTYEFVKQK-------
---------YLDYRRVPNSNP---P--EYEFLWGLRSYHETSKMKVLRFIAEVQKR---D
------PRDWTAQFMEAADEALDALDAAAA--EAEAR----AEARTRMGIGDEAV-----
------SGP--WSWDDIEFELLT-WDEEGDFGDPWS-RIPF----TFWARYHQNARSRFP
QTFAG---------------------P--IIGPGGTASA------NFAANFGAIGF----
--------FWVE------------------------------------------------
------------------------------------------------------------
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---------------------------------------HGSEKGVGMGLLHLQA-----
--------------------------------------------------------KASI
EDNT-VLTQTLM-------RASR--VRRIHLPTRPH--TW--------------------
------------------------------------------IT--DXXXXXXXQPPTA-
S------------------------------------------------EMAD-------
------IQVLAAAARPKT------------------------------------------
-----------------------------AF---------------KAQ-----------
-------------NAT----------------TKGPNGAYDFSQALNAKDMP-NAPTKAA
F-------------------KSQNAAP--KGPNAAYD-------FSQAATT---------
----SELTANKSEMAFKAQSAT-TKVGQNN---------T-YSFSQSLSASEVANTQPKT
------------------------------------------------------------
----------------------------------------------AFKAWNDTTKAPTV
-------------------------------DTQI-----------QNI-----------
----NQA---KMATSQ--------TEVETN--PG---------IPESDGAAAQTSADGSQ
AQNLE--------------------S---------------------------------R
TIIRGKRTRKINNLNV---------DENSSGDQRRAPLTAGTWRSAPVPVTT-QNPPGAP
PNVLWQTPLA----WQNPS----GWQNQPARQTP----P-ARQSPPARQTPPAWQNPVAW
QNPVIWPNPVIWQNPVIWPNPI-VWPGPVVWPNPLAWQNPPGWQTPPGWQTPPGWQGPPD
WQG---PPDWPLPPDC-LLPP-DWPLS-TDGPLPPD-----WSISPDWQNLT--------
------------------------------NKLIQ------YLMLKY-YTKKCC--G---
------------------------------------------------------------
----------------------ISGINALMFILEKKFGIQLKEIDKSTFP----------
---SWH-TGDKDT-PKLG---VLL----------VALGI----------IF--------M
-NGNC----A-S--EAVLWETLSKMGPS--SGVRYSLLRDLRKLLVYEFVKQK-------
---------YLDYRQMLNSNP---L--EYEFLWGLCSYHKASEMKVLRFIAKVQKR---N
------PCHWTASFMEAEKEALNALNTASA--EAED--------------QDEAV-----
------SGP--RTWDDIEFG------------------------------YHQNAHSRFP
QTFPM---------------------P--L----------------FSANFGVIGF----
--------FWVE------------------------------------------------
------------------------------------------------------------
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--------------------------------------MPRGQK---SKLRARERR-RQA
-RE-----GSQD------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------LGPRT---A
T--FTATTAA-A------------------------------------------------
------------------------------------------------------------
-----------------VS----YMRSNEGT---------------S--E-VQ-GRP---
-----------------------------RS-FQNPIATEPFHRSPLGEKVFILV-----
-------YYLLYKYQTKEPIT-KADML--RNVIQIYR-----NYFHVILRKASDH-----
----LELVFGLD---------MKE-VDPNR---------HIYV-----------------
-------L----------------------------------VNKLEP-SYD----GRLS
----NESSVPETGLL-------MTVLGVIFTKGNC------ATEE---QVWEVLNMM---
-----GLY-PGR----KHFIYGEPRKLITRDLVKE------NYLEYRQV-VNSDPPRYEF
----LWGPRAHAETS--KMRVLEFLAKIHDTIPS----A-FPSYYEE---ALRDEEERAQ
AR-AAAKALIA-AR----------------------------------------------
----------------------------------------------------------AN
--------------------ARS--K-----------------------AMAS-ARSRAT
ASS---------------SSH-P-------------------------------------
------------------------------------------------------------
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------------------------------------------

------------------------------------------------------------
------------------MSQ--LSKNLGDSSPPAEAPKPP-------------------
----------VYSRPTVLMRAP-----PASSRAPPVPWDPPPIDLQA-SLAAWQAPQPAW
EAPQGQLPAPV---PPMAQPPALGAPLVQAPPLGGPMGKPPT------------------
---------------PGVLMVHP-PPPGAPLAQPPTPGVLMVHPSAPGAPMAHPPP-PGT
PMAHPP-------------------------P----------------------------
------------------------------------------------------------
--------------------------------PGTPMAHPPPPGTPMAHPPPPGTPMVHP
PPPGTP--MA-------------------HPPPPGTPMAQP---PAPGVLMAQPLTPGVL
MVQPA-------------APGTPMAQPP---PPTAVM-------------------TQPP
PAGAPLAKPPGPGVLMMHPPGPRVPITQPPASG---------------AAMAQPAAP---
----PAQPMASWAQQAQPLILQIQSQVI----R-------APPQV---P-----------
-------Q---G------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------P-----------QAVH--CPSIIWQAPKGQPPVPHE--------------
------------------------------------------------------------
------------------------------------------------------------
---------MPSSMEYQEVQP-TQ-AV--TWQAPKAP-----THFWQPLPAQEAQRQ---
----GPPLVQLE-------QPFPGAPPSQKALQIQL-PSQQAQPS--GPQAELPQLQLQS
SWQAPPAVLQAQPGAPVAAANFPRGSAKSLMTP-SGDSRASSVEGRATS-KE----RRTS
SK--DRRAPPKDRM----------IFAATFCAPKA----VSPARAHQPAAWKNLPATSET
FTATPRVF-PAT----SQFQPASSNAFKGPSATSE----TPKSLPFAL---QDPFACVEA
LPAVPWVPQPHVNA---SQAVPTILM-ATAAAPQ----A-TAAV-PE---ASKTSLEPPR
RS-----------------------GKA--------------------------------
--TRK-----KKHLEAEE-DSRGHALA-------------------------------FR
--D-WQGP----RAWENPN--VSGW--EVQSPLQ-V--LGDRACPNAPHSLSGWEGPRTS
-RI---------------LSG---WEGPSTSWVLSAWEGLSTLR-A--------------
---------CGLS---------------EVPGSPQPLTTSEVP-------------S---
VTQGPSATQDGPKGE-AQPLSPL---NERANTLVQ------FPLVKD-QAKVPL--QR--
------------------------------------------------------------
----SEM---VKLIIREYKDECLDIINRANNKLECAFGYQLKGIDTQNHAYM-IINKLGQ
PKSEAV-ASLLDK-PKLG---LLM----------VVLSL----------IF--------M
-KGNC----V-R--EDLIFDFLFKLGLD--VRETSGLFGNTKKLITEVFVRQK-------
---------YLECRRIPYTEP---A--EYEFLWGPRAFLETSKMLVLRFLARLHTK---D
------PRCWPFHYLEALAECESEDVDEDE-PEA--GD--SA-------GSS--------
---TSSPRPH--------------------------------------------------
------------------------------------------------------------
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------------------------------------------

------------------------------------------------------------
------------------MSL--VSQNSRRRRRRVAK---ATA-----------------
----------H-NSSWDEMQAPNAPGLPADMPGSDVPQGPSDSQILQ-GLCAS-------
---EG-----------------PNT------------SVLPT------------------
---------------SAEGPST---------FVPPTIS---EASSASGQPTV-SEG-PGT
SLLATP---------------S-EG----LSTSGPPTIS---------------------
-----KGLCTSVTLAASEGRN------TSRPPTSSEEPST---S----------------
--------------------------V-----------------------------TSVV
PTPDEGPSTS-------------------V------------------------------
--------------------TS---VP-----PTATEG------------LST---PVPP
T------PDKGPSTSMPATPGEGPSTSVLPAAS---------------DGQSIS------
------------------------------------------------------------
------------------------------------------LVPTPGKGSSTSGPPTAT
EGLSTSV---------QPTAGEGLST----------------------------------
----------------------------------------------------------SV
----------PPT----------------------------------------------P
GEGLSTS---------VPPTAT--------------------------------------
-----------------------------------------------------------E
GLST--------------------------SVPP-----T---------------PGEGP
ST-SVLP-TPG------E-GRS-TCVPPT-ASD-VS--D---T-SVP---PT-PGE----
G--PSTLVQP----------------TASDRP--------------GSSVLPNP------
---GEGRSTLFSSSA-----SVDRNPSKCS-IVLPSPRVTKA------------------
----------------S------VDSDSEGP---------------K-------------
-------GAEGPVEFEVLRDCESPNSITIMGLSTSRVAITLKPQDPMEQNVAELL-----
-------QFLLVKDQSKYPIR-ESEMR--EYIVKEYR-----NQFPEILRRAAAH-----
----LECIFRFE---------LRE-LDPEA---------HTYI-----------------
-------L----------------------------------LNKLGPVPFE-----GLE
----ESPNGPKMGLL-------MMILGQIFLNGNQ------AKEA---EIWEMLWRM---
-----GVQ-RER----RLSIFGNPKRLLSVEFVWQ------RYLDYRPV-TDCKPVEYEF
----FWGPRSHLETT--KMKILKFMAKIYNKDPM----D-WPEKYNE---ALEEDAARAF
AEG---------------------------------------------------------
------------------------------------------------------------
----WQALPHFRRPFFEE----------AAAE------------------VAS-PD----
-SE---------------------------------------------------------
---------VSSY-------------------------A---------------------
---------SKYAPH-SWPESRL---ESKARKLVQ------LFLLMD-STKLPI--PK--
------------------------------------------------------------
----KGI---LYYIGRECSKVFPDLLNRAARTLNHVYGTELVVLDPRNHSYT-LYNRREM
EETEEI-VDSPNR-PGNN---FLM----------QVLSF----------IF--------I
-MGNH----A-R--ESAVWAFLRGLGVQ--SGRKHVI--------TCRYLSQR-------
---------YIDSLRVPDSDP---V--QYEFVWGPRARLETSKMKALRYVARIHRK---E
------PQDWPQQYREAMEDEANRADVGHR-QF----------FVHNFR-----------
------------------------------------------------------------
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--------EWPLPPRYWPPAT-PVGHL-PIRPFPPDWIPTDWPVPPDWQNLRPSPNLRP-
-SPNSRASHNLGASQ-TRDVALL---QERANKLVK------YLMLKD-YTKVPI--KR--
------------------------------------------------------------
----SEM---LRDIIREYTDVYPEIIERACFVLEKKFGIQLKEIDKEEHLYI-LISTPE-
SLAGIL-GTTKDT-PKLG---LLL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPLLGDLRKLLTYEFVKQK-------
---------YLDYRRVPNSNP---P--EYEFLWGLRSYHETSKMKVLRFIAEVQKR---D
------PRDWTAQFMEAADEALDALDAAAA--EAEAR----AEARTRMGIGDEAV-----
------SGP--WSWDDIEFELLT-WDEEGDFGDPWS-RIPF----TFWARYHQNARSRFP
QTFTG---------------------P--IIGPGGTASA------NFAANFGAIGF----
--------FWVE------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------

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------------------------------------------------------------
--------------------------------------MLLRQ-----------------
-----------------KRQ-SCKAE-E----------------GRQA----QGD-APG-
-------------LMDVQILTTEE------------------------------------
-----------------------------------------------------------Q
K-A---------------------------------------------------------
------------------------------------------------------------
----ASSSSTLI----AGT--LEE------------------------------------
---------VP--------------------------------------DSGS---LSPA
QSPRGASS---SLTVTD-D--TLWSQSNE----------------VSSS--NEEEGP---
------------S------TSPDPA------------HLESLFREALDEKVAELV-----
-------HFLLRKYQIKEPVT-KAEML--ESVIKNYK-----NHFPEIFSKASEC-----
----MQVIFGID---------VKE-VDPAG---------HCYV-----------------
-------L----------------------------------VTCLGL-SYD----GLLG
---DD-QSTPKTGLL-------IIVLGMIVMEGSC------APEE---AIWEALSVM---
-----GLY-DGR----EHSAYWELRKLLTQDWVQE------NYLEYHQV-PGSDPVRYEF
----LWGPRALAETS--YVKVLEHVARVNARVRI----S-YPSQSNR---CEATGESGGV
YMP---------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------MPRA-P----------------
-----------------KRQ-RCMPE-E----------------DLQS----QSE-TQG-
-------------LEGAQAPLAVE------------------------------------
-----------------------------------------------------------E
D-AS-----------------------SSTS-TSSSF----PSS----------------
-----------------------------------------------------------S
S-SSSSSCYPLI----PST--PEE--VSA---------------------ADE-------
----------T--------------------------------------PNPP---QSA-
---QIACS---SPSVVA-S--LPLDQSDE----------------G-FSS-QKEESP---
------------S------TLQALP------------DSESLPRSEIDEKVTDLV-----
-------QFLLFKYQTKEPIT-KAEIL--ESVIKNYE-----DHFPLLFSEASEC-----
----MLLVFGID---------VKE-VDPTG---------HSFV-----------------
-------L----------------------------------VTSLGL-TYD----GMLS
---DV-QSMPKTGIL-------ILILSIIFIEGYC------TPEE---VIWEALNMM---
-----GLY-DGM----EHLIYGEPRKLLTQDWVQE------NYLEYRQV-PGSDPARYEF
----LWGPRAHAEIR--KMSLLKFLAKVNGSDPR----S-FPLWYEE---ALKDEEERAQ
DRIATTDDTTA-------------------------------------------------
------------------------------------------------------------
-----------------------MA--------S----------------ASS----SA-
------------------------------------------------------------
---------TGS---------------------FSYP-----------------------
-------------------E----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
---------------------------------------SHS-Q----------------
-----------------KSE-HCKLE-E----------------DLQD----PRE-AQG-
-------------LESLQAPMAEE------------------------------------
-----------------------------------------------------------E
A-TT--------------------------------------------------------
------------------------------------------------------------
--TTSSSLSPLV----QGT--PEAM---P---------------------AAG-------
----------T--------------------------------------PSVP-------
QSSQRACS---SPTATI-A--TPSSQSDE----------------S-SRS-QEEEGP---
------------STPQ---------------------------PPVLHKKVAELV-----
-------QFLSVKYITKEPIT-KAEML--KSILKEHK-----DHFPVVFKKVCEC-----
----MEVVFGIE---------VKE-MDPTS---------HSYV-----------------
-------L----------------------------------VKTLDL-TYD----GMLS
---D-DQGMPKTGLL-------ILILGIIFMEGNR------APEE---KIWEVLNMM---
-----GVF-AGK----KDFIYGEPRKLITKDLVQE------KYLEYRQV-PNSDPARYEF
----LWGPRAHAETT--KMKVLQFFAKISGTDPA----S-FPYWYEE---ALRDERERAQ
AGVAVDDT-TA-------------------------------------------------
------------------------------------------------------------
-----------------------MA--------S----------------VSS----SV-
------------------------------------------------------------
---------MSS---------------------SFSC-----------------------
------------------PE----------------------------------------
------------------------------------------------------------
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------------------------------------------

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------------------------------------------------------------
------------------------------------------------------------
--------------------------------------MPRGQK---SKLRAREKR-RQA
-RS-----EAQDL-----------------------------------------------
-ER-------------AQATAPA-------------------------------------
-----------------------------------------------------------A
GESF-------------------------STACA-----L---------------SGGHP
ENFP-A------------------------AATAS-------S-------PQAPKG---A
S--GSTSASV-A------------------------------------------------
------------------------------------------------------------
-----------------VS----CTDSDEGA---------------KS-E-DE-GSP---
------------------------------N-S--SSGTEVSRRDPLNKKVVLLV-----
-------QFLLQKYQNKEPIT-KADML--KLVIKKYR-----CHFNEILKRASEH-----
----MELAFGVD---------LKE-VDPIR---------HCYA-----------------
-------L----------------------------------VSKLDL-TFD----GTMR
----EEENMPKTGLL-------MIVLGVIFMKDNC------AAEE---EVWEVLNMM---
-----GVY-ANR----KHFIYGDPRKVITEDLVQL------RYLEYRQA-PDSFPPRYEF
----LWGPRAHAETS--KMRVLEFLAKVHDTVPT----A-FPAWYEE---ALKDEEERAQ
TR-AAARAQTA-AL----------------------------------------------
----------------------------------------------------------VR
--------------------ARA--R-----------------------ALAG-GVSHTN
ASN---------------PYL-APKHPQ---------CA---------------------
------------------------------------------------------------
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---------------------------------------------------METQIRREG
LGCSPASIKRKKKKEDSG--HLGLQVSTMFSEDDFQST---EGAPSGPQI----------
---------QWSQDLPRVQVFRE----------QANQE---DRSPR-RTQRITGG-EV--
-----------------LWGPITQIFPTVWPADLTGVIMPLEQ-----------------
-----------------RSQ-HCKPE-E----------------GLQA----QED-NPG-
-------------LVGGAQALQAE------------------------------------
-----------------------------------------------------------E
Q-E---------------------------------------------------------
------------------------------------------------------------
---AASFSSTLN----VGT--LEE------------------------------------
---------VP--------------------------------------ATES---PSPP
QSPQGESS---SPTAMD-S--IFGSLSDE----------------GSSS--QEEEGP---
------------S------TSPDLI------------DPESFSQDILHDKIIDLV-----
-------HLLLRKYRVKGLIT-KAEML--GSVIKNYE-----DYFPEIFREASEC-----
----MQLLFGID---------VKE-VDPTS---------HSYV-----------------
-------L----------------------------------VTSLSL-SYD----GIQG
---DE-QSMPKSGLL-------IIVLGVIFMEGNC------VPEE---VMWEVLSIM---
-----GVY-AGR----EHFLFGEPKKLLTHDWVQE------KYLVYRQV-PGTDPACYEF
----LWGPRAHAETS--KMKVLEYIANANGRDPS----S-YPSLYED---ALREEEEGV-
------------------------------------------------------------
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--------------------------------------MSLEQ-----------------
-----------------RSP-HCKPD-E----------------DPEA----QRE-DLG-
-------------LMGAQDPTGEE------------------------------------
-----------------------------------------------------------Q
E-A---------------------------------------------------------
------------------------------------------------------------
---SSSS-D---------E--EEE------------------------------------
---------VS--------------------------------------AAGS---SSPP
QSPQGGSS---SSTSVY-Y--TLWSQFDE----------------GSSS--QEDEGP---
------------S------TSVDLA------------HLEFMFQEALKLKVAELV-----
-------RFLLHKYRVKKPVT-KAEML--ESVIKNYK-----HYFPVIFGKASEF-----
----MQLIFGTE---------VKE-VDPAG---------PSYI-----------------
-------L----------------------------------VTALGL-SCD----SMLG
---ND-HSMPKAALL-------IIILGVILTKDNC------APEE---VIWEALSVM---
-----GVY-VGM----EHVFYGEPRKLLTQDWVQE------NYLEYRQV-PGSDPAHYEF
----LWGSKAHAETN--YEKVINYLVMVNAREPI----C-YPSLYEE---AFGGEQEGV-
------------------------------------------------------------
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--------------------------------------MPRGQK---SKLRAREKR-RQN
-RA-----EAQGL-----------------------------------------------
-KS-------------AQAATAEG------------------------------------
-----------------------------------------------------------E
-AT--------------------------ASSPP-----V---------------TGDGA
SSSS-D-------------------------AGS----------------LQAPAS---V
S--AA-TSATAG------------------------------------------------
------------------------------------------------------------
-----------------VS----CKSSDVRG---------------KS-H-VQ-KSK---
-----------------------------KS--QAAHCSESSGQDLLTRKAGILA-----
-------NYLLCKYKMNEPIK-KGDML--KVIHRRYR-----EHFPEILKKASER-----
----MDLFFGLE---------VKE-VKPNS---------HSYS-----------------
-------L----------------------------------VCKLDD-TSE---GSV-S
----FAWQFPTKGIL-------MPLLGLIFLNGNR------ASEE---EIWELLNIL---
-----GVY-AGK----THFIFGEPRKLITQDLVQE------NYLEYRQV-PGSDPPRFEF
----LWGPRAQAETT--KAKVLDFLSKVKDTVST----D-FPPRYEE---ILRDEQERAR
AT-EATMAGAT-DK----------------------------------------------
----------------------------------------------------------AR
--------------------ARS--R-----------------------ATSS-RDPP--
-PE---------------------------------------------------------
------------------------------------------------------------
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---------------------------------------MDRRNDYGYRVPPFQ--G---
--------PLPPP--GSLGLP----------------------------LPPDIQTETTE
EDSV-LLMHTLL-------AATK--DSLAVDPPVVSRPKK-------------SKTKKAP
IKAI----------TKA-APA--APPVPTANEIATNKPKITLQALNLPVITQISQASPT-
T------------------------------------------------EVTN-------
------TQVSSVTAQPKKANKMKRVTAKAAQG-SQSPTGREGGATQLKSPLQVLNLPVIS
QNIHA---SIANESASSQTL-ITSIKPKKAS---------------KAK-----------
-------------KAA----------------NKAIASATEVSLAPTATHTA-TTQGQIT
-NETASIHTTAASIRTKKASKARKIIA--KVINTDTE-------HIQAANV---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------TETAT
RQIEA--------------------S---------------------------------V
IAIRPKKSKGKKAASRGP---------N------------SVSEISEALLATQMVTNQAL
AATLRVKRGS----RARKA----STKARATESQT----PNADQGAQAKMASAQ-TNVSAL
ETQ------------VA------------AAVQALADDYLAQL----SLEPTTRTRGKRN
RK-----------------------------------------------SKHLNGDERS-
GNNYRRIPWGRRPAP-PRDVAIL---QERANKLVK------YLLVKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LRDVIQEYDEYFPEIIERASYALEKMFRVNLKEIDKQSSLYI-LISTRES
SAG-IL-GTTKDT-PKLG---LLM----------VILSV----------IF--------M
-NGNK----A-S--EAVIWEVLRKLGLH--PGVRHSLFGEVRKLITDEFVKQK-------
---------YLEYKRVPNSRP---P--EYEFFWGLRSYHETSKMKVLKFACKVQKK---D
------PKDWAVQYREAVEMEVQAAAVAVA--EAEAR----AEARAQMGIGEEAV-----
------AGP--WNWDDMDIDCLT-REELGDDAQAWS-RFSF----EIEARAQENADASTS
VNFSRGAGTRAGFSDGASISFNGAPSS--S----G-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------GPGITFGGAPSSSASFSNTASISFGGTLSTSS----------------
--------------------SFS------------------S----------------AA
SISFGGAPSTSTSFSSEASISFGGTPCTSASFSGGVSSSFSGPLN--TSATFSGAASSGF
GG------------------TL-STTAGFSSVLSTSTSFGSAPTTNTVFSSALSTSTGFG
GTLSTSVCFGGSPSSSGSFGGTLSTSICFGGSPCTSTGFGG----TLSTSVSFGGPSSTS
ANCGGTLSTSICFDGSPSTG-AGFGGALNTSASFGSALNTS-------------------
-------------------------------------------------AGFGGAMSTSA
DFGSTLSTSVCFGGSPGTSVSFGSALNTSAGFGGAVSTSTDFGG----------------
------------------------------------------------------------
-----TLSTSVC------------------------------------------------
----------------------FGGSPSTSAGFSGALNTNASFGCAISTSAGFSGAVGTS
AGFSGVPSTNPGFGGAFNTSAGFGGALSTTTDFGGTPNNSIGFGAAPSTSVSFGGAHSTS
LCFGGAPSTSLCFGSASNTNLCFGGPPSTSACFSGATSPSFGDGPSTSTGFSFGNGLSTS
AGFGGGLNTSAGFGGGLGTSAGFSGD------------------------------LSTS
SGFDGGLGTSAGFSGGPGTSTGFGGGLGTSAGFSGGLGTGAGFGGGLVTSDGFGGGLGTN
ASFGSTLGTGAGFSGGLSTSDGFGSRPNASFDRGLSTIIGFGSGSNTSTGFIGEPSTSTG
FHSGPSSIVGFSGGPSTGVGFCSGPSI-SGFSGGPSTGAGFG------------------
------------------------------------------------------------
-------GGPNTGAGFGGG-PSTSAGFGSGATSLGACGFSYG

------------------------------------------------------------
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--------------------------------------MSRD-Q----------------
-----------------KIP-QCTPD-Q----------------HLQT----QSE-TQG-
-------------LESAQVPKPME------------------------------------
-----------------------------------------------------------E
A-----------------------------------------------------------
------------------------------------------------------------
---LPSSSLLPM----SDN--LKEA---P---------------------AAK-------
----------V--------------------------------------LSAP-------
EGPQSFCS---SSGDNT-A--TSSSKPDD----------------DSSSK-EEKKSL---
------------S------TSEATE------------NPENTLIDALEKKVAFLV-----
-------NFLLLKYRMEALVT-KADIL--NIIIKDDE-----EHFSEIFLRASER-----
----MEMIFGLD---------VKE-VDPTS---------HCYA-----------------
-------I----------------------------------YIKLGL-TYD----GKLC
---PP-EGLPKTGLL-------ILMLGVIFMNDNC------VSEE---EVWRVLNIT---
-----GIF-SDQ----KHFIFGDPKEFITKDLVKE------KYLEYRQV-ADSDPAQYEF
----LWGPRAHAEVR--KMEILEFLAKVHGTDPK----S-YPSQYED---ALRNEEERAQ
GRISVSAASTS-------------------------------------------------
------------------------------------------------------------
-----------------------MA--------T----------------ESS----SA-
------------------------------------------------------------
---------MSD---------------------SISH-----------------------
------------------T-----------------------------------------
------------------------------------------------------------
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--------------------------------------MPRGQK---SKLRAREKR-RQA
-QS-----EAQGV-----------------------------------------------
-QD-------------AQATTAAE------------------------------------
-----------------------------------------------------------E
-QPL-------------------------TFPFP-----P---------------FGGNA
QSSL-A------------------------AGSGR-------K-------SQGPHT---A
P--ST-TISA-G------------------------------------------------
------------------------------------------------------------
-----------------VS----HTRSDEGA---------------QS-Q-DE-ERP---
-----------------------------ST-SQAQPSTDHYRRTLLDDKAILLV-----
-------QFLLRKYNIREPIT-KEDMM--KYVIRKHK-----EHFHEILRKASEL-----
----MVLAFGID---------LKE-VDPTR---------HCYA-----------------
-------L----------------------------------VSKFQS-TYD----DRLR
----GEEIMPKTGLL-------MTILCVIFMKGNC------ATEE---DIWEVLNVM---
-----GIY-AER----KHLIYGDPKKLITQDLVQE------RYLQYQQV-ANSDPPRFEF
----LWGPRAHAETS--KMKVLEFLAKIHDTVPS----A-FPSWYEE---ALRDEEERTR
AR-FAALLRTG-AL----------------------------------------------
----------------------------------------------------------AN
--------------------VSP--R-----------------------VNFG-SFFHL-
------------------------------------------------------------
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--------------------------M-DRRQQSFSPGDSVPSFFMMMKSKHLNGDERS-
GINYRRIPWGRRLPP-PRDVAIL---QERANKLVK------YLLVKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LKDVIQEYDEYFPEIIERASYALEKMFRINLKEIDKQSSLYI-LISTRES
SAG-IL-GTTKDT-PKLG---LLM----------VILSV----------IF--------M
-NGNK----A-S--EAVIWEVLRKLGLH--PGVRHSLFGEVRKLITDEFVKQK-------
---------YLEYKRVPNSRP---P--EYEFFWGLRSYHETSKMKVLKFACKVQKK---D
------PKDWATQYREAVEMEVQAAAVAVA--EAEAR----AEARAQMGIGEEPM-----
------YS-----LEICPHSSL--------------------------------------
------------------------------------------------------------
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---------------------------------------MDRRNDYGYRVPLFQ--G---
--------PLPPP--GSLGLP----------------------------FPPDIQTETTE
EDSV-LLMHTLL-------AATK--DSLAMDPPVVNRPKK-------------SKTKKAP
IKTI----------TKA-APA--APPVPAANEIATNKPKITWQALNLPVITQISQALPT-
T------------------------------------------------EVTN-------
------TQASSVTAQPKKANKMKRVTAKAAQG-SQSPTGHEGGTIQLKSPLQVLKLPVIS
QNIHA---PIANESASSQAL-ITSIKPKKAS---------------KAK-----------
-------------KAA----------------NKAIASATEVSLAATATHTA-TTQGQIT
-NETASIHTTAASIRTKKASKARKTIA--KVINTDTE-------HIEALNV---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------TDAAT
RQIEA--------------------S---------------------------------V
VAIRPKKSKGKKAASRGP---------N------------SVSEISEAPLATQIVTNQAL
AATLRVKRGS----RARKA----ATKARATESQT----PNADQGAQAKIASAQ-TNVSAL
ETQ------------VA------------AAVQALADDYLAQL----SLEPTTRTRGKRN
RK-----------------------------------------------SKHLNGDERS-
GSNYRRIPWGRRPAP-PRDVAIL---QERANKLVK------YLLVKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LRDVIQEYDEYFPEIIERASYTLEKMFRVNLKEIDKQSSLYI-LISTQES
SAG-IL-GTTKDT-PKLG---LLM----------VILSV----------IF--------M
-NGNK----A-S--EAVIWEVLRKLGLR--PGVRHSLFGEVRKLITDEFVKQK-------
---------YLEYKRVPNSRP---P--EYEFFWGLRSYHETSKMKVLKFACRVQKK---D
------PKDWAVQYREAVEMEVQAAAVAVA--EAEAR----AEARAQMGIGEEAV-----
------AGP--WNWDDMDIDCLT-REELGDDAQAWS-RFSF----EIEARAQENADASTN
VNFSRGASTRAGFSDGASISFNGAPSS--SGGFSG-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------GPGITFGVAPSTSASFSNTASISFGGTLSTSS----------------
--------------------SFS------------------S----------------AA
SISFGCAHSTSTSFSSEASISFGGMPCTSASFSGGVSSSFSGPLS--TSATFSGGASSGF
GG------------------TL-STTAGFSGVLSTSTSFGSAPTTSTVFSSALSTSTGFG
GILSTSVCFGGSPSSSGSFGGTLSTSICFGGSPCTSTGFGG----TLSTSVSFGGSSSTS
ANFGGTLSTSICFDGSPSTG-AGFGGALNTSASFGSVLNTS-------------------
-------------------------------------------------TGFGGAMSTSA
DFGGTLSTSVCFGGSPGTSVSFGSALNTNAGYGGAVSTNTDFGG----------------
------------------------------------------------------------
-----TLSTSVC------------------------------------------------
----------------------FGGSPSTSAGFGGALNTNASFGCAVSTSASFSGAVSTS
ACFSGAPITNPGFGGAFSTSAGFGGALSTAADFGGTPSNSIGFGAAPSTSVSFGGAHGTS
LCFGGAPSTSLCFGSASNTNLCFGGPPSTSACFSGATSPSFCDGPSTSTGFSFGNGLSTN
AGFGGGLNTSAGFGGGLGTSAGFSGG------------------------------LSTS
SGFDGGLGTSAGFGGGPGTSTGFGGGLGTSAGFSGGLGTSAGFGGGLVTSDGFGGGLGTN
ASFGSTLGTSAGFSGGLSTSDGFGSRPNASFDRGLSTIIGFGSGSNTSTGFTGEPSTSTG
FSSGPSSIVGFSGGPSTGVGFCSGPST-SGFSGGPSTGAGFG------------------
------------------------------------------------------------
-------GGPNTGAGFGGG-PSTSAGFGSGAASLGACGFSYG

------------------------------------------------------------
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---------------------------------------INRRNDCGYRMLPFQ--G---
--------PMLPS--GILERH----------------------------FPLDTQTETTE
EDSV-LLMPTLL-------AATK--DPLAMGPPVANWPKK-------------SKTKKAP
IKSI----------TKA-IPA--APTVSSANEIATNKLKVTLQALNLPIIPQINQASVT-
T------------------------------------------------KT-N-------
------TQASSVTAQPKKANKTRRVTAKVAQA-SQYPTRKEGVTTQTKSSL---------
-AIQA---PLTSGSANSQAL-IVPTKPKKVS---------------KAK-----------
-------------KAA----------------NKAITSAVDIPLAPTTTHTT-TTQGQIN
-NEAATTHATTTCIRLI-ASKAKKPTV--KGINTDTE-------LLEAPNA---------
----ER------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------PS
RQTKA------------------------------------------------------S
IVARPPKFKGKKAANIDP---------N------------SACEVSEAPL-AQMITNQAL
AAALQVKRGS----RVHKS----VTKTQAAENQM----KIVDQGLQAKIATFR-TNMSAI
ETQ------------VA------------AAVQALADDYLAQL----SLEPTTSTWGKRK
QKVRSLTSPSL---------------------------------------------KFS-
LLFHSYLPRDWRLLP-PRDVAIL---QKRANKLVK------YLLVKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LKDVIQEYDEYFPEIIERASYALEKMFRVILKEIDKQSRLYI-LISTQES
SAG-IL-GTEART-SGAY---LTK----------NHLAS----------SF--------I
-GTAA----C-S--R-EVSSMFR-NVSS-LIWVRHSLFGEVRKLITDKFVKQK-------
---------YLEYKRVPNSKP---P--EYEFFWGLRSYHETSKMKVLKFAFKIEPQSPLY
------AKDWAAQCQEAVEMEVQAAAVAVA--ETEAR----AEARAQMGIGEEAV-----
------AGP--WNWDDMDIDCLT-REELGDDAQSWN-RFSF----EIETRAQENAEASTN
IDFSRGVSTRATFSDSACISFNGVPSP--SGGFGG-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------RAGTSFGGTPRTSASFSSTASICFSGIPSTSTSFSG------------
----------------------------------------------------------AA
SISFSGAASTSSSFNSEACISFGGTPCTSAGFGGGVSSSFSIPLS--SSPGFSGGASSGF
GG------------------TL-STTAGFSGALITSSSFGSLPRTSTVFSGALSTSTGFG
GTLSTSVCFGGSPSSGASFGGTLNTSICFGSSPSTTNGFDG----VLSTSVSFGGSSSTS
ADFGGTLSTSICFGGSPSTG-ASFGGAFSTSVGFGGALNTSAGFNST-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------SAISTSASFSSTPSTISGFGSVFSTS
ADFSGALTTTTDFG--------------------ITP--------------------STN
IGFGGVPSTSLCFGSVSNANLCFGGPPSTSACFSGPTTASFGDGSSTTAGFIFGSGLNSS
AGFSGGLSTSAGFSSGLG------------------------------------------
----------------------------TSAIFGSGLSTSAGFGGGLISSDGFGDGLGTN
AGFSSTLGTSAGFSGGLSISDGFGAGFNNSFNGGPSTIIGFGSGSNTSTGFIGEPCTSTS
FNGGPSSIIGFSSGPSTGAGFSSGPSSGAGFGGGPR------------------------
------------------------------------------------------------
----------------------NGAGFGGGATSLGACSFSYG

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------MLNQKSLQ-------CSNDPPLQ----P-HSNDQED-----------SQ
VTKT----LEL----S------SSDS----------------------------------
------------------------------------------------------------
--------------------------------------------------LVP-------
------------------------VSVKE-ASGAGIASTPEVPQ-GIGISATSMIATS--
---------SSSC------------------S------DDDDD-------------DDDE
DEEDNIHLSQPD---PRNARVSQ---DRDMDFLVN------FVLFSC-QIEEPM--VK--
------------------------------------------------------------
----EEI---LRIIIK----GYEDQFLKASEHMEITFGLDVGKIDFINHCYS-FLIKFSL
TYDGIP-SGEVGI-PKAG---ILI----------LVL------------VV--------F
-EGSC----A-T--E-KILEVLGVRGSY--PGVKHFIFGEPMKFFTNDFMKEE-------
---------YLVYGKVASSNP---T--RFEFLWGQRAHAETTRMKVQ-FLVKVCGI---D
------PSSFPV--------------CEEALQDEEV-------RV----QAS--------
----------------------------TS------------------------------
------------------------------------------------------------
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------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------MQAPNVPGLPAAMPGPDVPEGPSDPQILQ-GLCAP-------
---EG-----------------PGT------------SVPST------------------
---------------PGEGPST---------SVLPAAS---EGSCASGPPTV-SEG-PNI
DLSIAA---------------S-ER----PNNPLPPTAS---------------------
-----EGSSASEH-----------------------------------------------
----------------------------PSVTEGLNTSELPLS--------NEGPSCFVP
PTSGEGLSTY-------------------LPPTSGEGPSTSVP------P--T-TSEGLS
ISAPPTSGEELS--------IL-----------------------------------MRP
T------VSEGPGINMPPFSGQGLSTSVPPTPD---------------ESPSTS------
------------------------------------------------------------
------------------------------------------VS----------------
DAPGTSV---------LPPSDEGRSIFTP---------------PTPDEGR---------
------------------------------------------------------------
------------------------------------------------------------
----STS---------LAL----T------------------------------------
-----------------------------------------------------------A
FEEP-----------------------------VASVLLL---------------SGNSS
KI-SGLQ--TS------GEGPS-TSRVSSATE--GL--G---L-SGM---PT-ASE----
N--PGALLS---------------------------------------------------
------------SSA-----SGSPNSSKCS-VALPNLGVAKA------------------
------------------------SADSEGP---------------K-------------
-------GAEGPVEFQVLRDHKNSNSITIMGLSTSQVALTLKPQDPMEQNVAELL-----
-------QLLLVKDQSKYPIR-ESEMR--QHIVKEYR-----NQFPEILRRVAAH-----
----LECIFRFE---------LRE-LDPEE---------RTYI-----------------
-------L----------------------------------LNKLGPVPFE-----GLE
----DSPNGPKMGLL-------MMILGEIFLNGNQ------AKEA---EIWEMLWRM---
-----GVQ-RER----RLSIFGNPKRLLSVEFVWQ------RYLDYRPI-TDCTPVEYEF
----FWGPRSHLETT--KMKILKFMAKIYNKDPM----D-WPEQYNE---ALEEDAIRAA
ADD---------------------------------------------------------
------------------------------------------------------------
----WQAVPQFRRPFFEE----------IPAD------------------LLS-PD----
-AE---------------------------------------------------------
---------VSGY-------------------------P---------------------
---------SKYPPH-SWPESRM---ESKARKLVQ------LFLLMD-STKLPI--PK--
------------------------------------------------------------
----KGI---LYYIGRECSKVFPDLLNRAARTLNHVYGTELVVLDPRNHSYT-LYNRREM
EDAEEI-IDSPNR-PGNN---FLM----------QVLSF----------IF--------I
-MGNH----A-R--ESAVWAFLRGLGVQ--TGRKHVI--------TCRYLSQR-------
---------YIDSLRVPDSDP---V--QYEFVWGPRARLETSKMKALRYVARIQRK---E
------PQDWPEQYREAMEDEANRAQAGHR-QI----------LIHNVR-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------

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------------------------------------------------------------
---------------------------------------MAQKMDCGAGLLGFQSPDA--
--CRAVCHPLPQPPAATLPLSCIPH-P--CDPPYSPQLLQAAPLLCHFLPLY-LQAEASV
EDST-LLMQTLM-------EAIQ--IS-EAPPTNQA--T---------------------
-------------------------------------------AAGPNASPQSSQPPTA-
S------------------------------------------------EMAD-------
------IQVLAAAARPKT------------------------------------------
-----------------------------AF---------------KAQ-----------
-------------NAT----------------TKGPNGAYDFSQALNAKEMP-NAPPKAA
F-------------------KAQNATP--KGPNAAYD-------FSQAATT---------
----SELTANKSEMAFKAQNAT-TKVGPNA---------T-YNFSQSLSASEMANTQPKT
------------------------------------------------------------
----------------------------------------------AFKAWNDTTKAPTV
-------------------------------DTQT-----------QNI-----------
----NQA---KMAASQ--------TEVET--SPG---------IPESDGAAAQTSADGSQ
AQNLE--------------------S---------------------------------R
TIIRGKRTRKINNLNV---------DENSGGDQRRAPLATGTWRSAPVPVTT-QNPPGAP
PNVLWQTPLA----WQNPS----GWQNQPARQTP----P-ARQSPPARQTPPAWQNPVAW
QNPVIWPNPVIWQNPVIWPNPI-VWPGPVVWPNPLAWQNPPGWQTPPGWQNPPGWQGPAD
WQG---PPDWPLPPDW-PLPP-DWPLP-TDWPLPPDWIPTDWPVPPDWQNLRPSPNLRP-
-SPNSRASQNLGASQ-PRDVALL---QERANKLVK------YLMLKD-YTKVPI--KR--
------------------------------------------------------------
----SEM---LRDIIREYTDVYPEIIERACFVLEKKFGIQLKEIDKEEHLYI-LISTPE-
SLAGIL-GTTKDT-PKLG---LLL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPLLGDLRKLLTYEFVKQK-------
---------YLDYRRVPNSNP---P--EYEFLWGLRSYHETSKMKVLRFIAEVQKR---D
------PRDWTAQFMEAADEALDALDAAAA--EAEAR----AEARTRMGIGDEAV-----
------SGP--WSWDDIEFELLT-WDEEGDFGDPWS-RIPF----TFWARYHQNARSRFP
QTFAG---------------------P--IIGPGGTASA------NFAANFGAIGF----
--------FWVE------------------------------------------------
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------------------MSL--VSQNSRRRRGGRAN---GR------------------
--------------------NSSGKGLPAAVP--DVPEGPSDPKVLQ-GPSAS-------
---DG-----------------PGS------------SVLPI------------------
---------------PREGPST---------SVPPTAP---EGSSASGQLII-SEG-PNT
SELPIS---------------GEEG----PGTSRPPAVS---------------------
-----AGLNTAMSITAAEGLS------TSVPPTAPNGSKA---SE-------HLDVSEGL
NI----------------------SE-QPHSDEGP--GVQPTL--------GEGLGTTVP
PTFSEESGIS--------------------------GLSTP-------VS--PTISEGPG
INVPSPASEAPS--------TS---VP-----PTATDG------------LG---INLPP
T------SAKGRSASVLLLASEEPDISVSPPSA---------------KGRSTS------
------------------------------------------------------------
------------------------------------------MPPPSGEVRSTWVLPTIL
EGSSVNM---------PPTSKKGLRTSVR---------------PAARENPST-------
------------------------------------S---------------AGGRGTPL
----------QSI----------------------------------------------A
AAGFGIS---------V-AS----------------------------------------
------------------------------------------------------------
---C------------------------AAEGSATCGLLP---------------CGEGP
S--------TS------GEGPN-TSQMPLAAEGRGA--S---A---M---ST--------
---------------------------AADNP----------------------------
------A--AVSCGA-----SAGMNLFKCTSLGLPK------------------------
-----------------------ASAPSVRP---------------K-------------
-------RSEGPLEFQVLRDSENSNSITIMGLGTAHVALTLKPQDPMEQNVAELL-----
-------QFLLVKDQSKYPIK-ESEMR--EFIVKEYR-----HQFPEILRRAAAH-----
----LECIFRFE---------LKE-LDPEE---------RTYI-----------------
-------L----------------------------------LNKLGPVPYD-----GLE
----DIPNGPKMGLL-------MMILGKIFLNGNQ------AREA---DIWEMLWRF---
-----GVQ-RER----RLSVFGNPKRLLSVEFVWQ------RYLDYRPI-TDCGPVEYEF
----YWGPRSHIETT--KMKILRFMARIYNKDPM----D-WPEQYNE---ALEEDALRNA
EDD---------------------------------------------------------
------------------------------------------------------------
----WRPVAPFRRPFFEE----------VPPE------------------LLA-PD----
-SD---------------------------------------------------------
---------APGY-------------------------S---------------------
---------SKYSPH-SWPESRL---ESKSRKLVQ------LFLLMD-STKLPI--PK--
------------------------------------------------------------
----KGI---LYYIGRECSKVFPDLLNRAARTLNHVYGTELVVLDPRNHSYT-LFNRREM
EDTEEI-VDSPNR-PGNN---FLM----------QVLSF----------IF--------I
-MGNH----A-R--ESAVWAFLRGLGVQ--NGRKHVI--------TCRYLSQR-------
---------YIDSLRVPDSDP---V--QYDFVWGPRARLETSKMKALRYVARIHRK---E
------PQDWPEQYREALEEEANRADAGNR-AL----------VVRNFR-----------
------------------------------------------------------------
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--------------------------------------MPRGQK---SKLRAREKR-HQA
-RC-----ENQDL-----------------------------------------------
-GA-------------TQATVAE-------------------------------------
------------------------------------------------------------
GESP-------------------------SSAYL-----L---------------FGDRP
QNLP-A------------------------AETPS-------I-------PEALQG---A
P--STTNAIA-P------------------------------------------------
------------------------------------------------------------
-----------------VS----CS-SNEGA---------------SS-Q-DE-KSL---
------------------------------G-S--SREAEGWKENPLNKKVVSLV-----
-------HFLLQKYETKEPIT-KGDMI--KFVIRKDK-----CHFNEILKRASEH-----
----MELALGVD---------LKE-VDPIR---------HYYA-----------------
-------F----------------------------------FSKLDL-TYN----ETTS
----DEEKIPKTGLL-------MIALGVIFLNGNR------APEE---AVWEIMNMM---
-----GVY-ADR----KHFLYGDPRKVMTKDLVQL------KYLEYQQV-PNSDPPRYEF
----LWGPRAHAETS--KMKVLEFVAKMHDTVPS----A-FPSCYEE---ALRDEEQRTQ
AR-AAARAHTA-AM----------------------------------------------
----------------------------------------------------------AN
--------------------ARS--R-----------------------TTSS-SFSHAK
------------------------------------------------------------
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----------------------CKLE-E----------------GLQA----QSE-TQD-
-------------Q-GAQVPGTEE------------------------------------
-----------------------------------------------------------E
VFSP---FF------CS-------------------------------------------
------------------------------------------------------------
----SFFTSFLI----PGN--LEE------------------------------------
---------VS--------------------------------------AAEM---PSTP
QGPQSAYS---CSSAQA-A--APWSLSDQ----------------GSSR--QGKESP---
------------G------TSQLQP------------DAESLLRDEIGDKVAEMV-----
-------TFLL----VKEPFT-RAEML--EAVIQNQK-----DHFSVIFGEASEC-----
----LQLVFGID---------VKK-VDPAG---------QCYV-----------------
-------L-----------------------------------AMLGL-TYD----GTLS
-D--G-HSMPKTGLL-------VMVLGVIFLEDNC------IPET---EIWEFLSVM---
-----GVY-PGR----KLFSCREPRKLLTRNWVRE------QYLEYQQV-PGSEPAC---
-----WGPRAHAKAR--RIKVLEGLAKVYGPVLS----T-FPTLYEE---VLRDEEDR--
------------------------------------------------------------
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------------------------------MPQ---------------------------
----------------------SKKSK-------------------------------AH
--------------------GGDKCP-QAQGKTQS---CGGAQAIATAEEEST--TSSL-
---------------------QCEDITQS-LPGAESCSTSRERQ-R-------------V
---------PTIA-----------------TTALFSYTRSCEA-------------FDG Q
S----LAYEVPPFTE-TPGTDCL---TRKPSLLEQ------FLLYKY-KMKQLM--VK--
------------------------------------------------------------
----EDI---LKIIHQSHHDRFAEILKRASECTELVFAVDLKEVDSVVPCYN-LVSKLKL
PNNGRV-RGRRGL-PKTG---VLM----------NLLGM----------IF--------L
-KGNC----A-P--EEDIWKYLGTMRVY--AGRKHIIYGEPRKLITKDLVRLK-------
---------YLEYHQVANSDP---P--PYEFLWGPKAHLETREMKVLEFLAKVNDA---V
------PSDFPAYYEEALRDEEEKAQGMHA-ARPDTTVKVSIPPRDMLNIII-PPIKK--
------SPPG-AGK--EGVLCSR-SSA---------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------MSQ--LSKNLGDSSPPAEAPKPP-------------------
----------VYSRPTVLMRAP-----PASSRAPPVPWDPPPIDLQA-SLAAWQAPQPAW
EAPQGQLPAPV---VPMTQPPALGGPIVPAPPLGGPMGKPPT------------------
---------------PGVLMVHP-PPPGAPMAQPPTPGVLMVHPSAPGAPMAHPPP-PGT
PMSHPP-------------------------PPGTPMAH---------------------
-----P---------P------------------PPGTPM----A-------HPPPPGTP
------------------------MVHP--PPPGTPMAHPPPPGTPMAHPPPPGTPMAHP
PPPGTP--MA-------------------HPPPPGTPMAQP---PAPGVLMAQPLTPGVL
MVQPA-------------APGAPMVQPP----PAAVM-------------------TQPQ
PSGAPMAKPPGPGVLMIHPPGARAPMTQPPVSG---------------APMAQPAAPPAQ
PMAPPAQPMASWAPQAQPLILQIQSQVI----R-------APPQV---P-----------
-------Q---GPQAPPAQLATPPGWQATSPGWQATPQGWQTTPLTWQTTQVTWQAPA--
----------ITWQVPPPM-RQGPPPIRP-------------GPPPIRPGPPPVR---QA
PPLIRQ---APPVIRQAPP-VIRQAPPVIRQA-------PPVIRQAPPVIRQAPPVIRQA
-PP---------V-----------------------------------------------
--------IRQAPPLIRQAPP-PI------------------------------------
-----------------------------------------------------------R
--------------PAPQVLGTQPPLWQALPPPP-----P---------------LRQAP
QARLPAPQVQA------------V-----------------------------PQP---V
L--PAPLSAP----------------------------------------LS--------
---------AP-----------QAVH--CPSIIWQAPKGQPPVPHE--------------
------------------------------------------------------------
------------------------------------------------------------
---------IPTSMEFQEVQQ-TQ-AL--AWQAQKAP-----THIWQPLPAQEAQRQ---
----APPLVQLE-------QPFQGAPPSQKAVQIQL-PPQQAQAS--GPQAEVPTLPLQP
SWQAPPAVLQAQPGPPVAAANFPLGPAKSLMTP-SGECRASSIDRRGSS-KE----RRTS
SK--ERRAPSKDRM----------IFAATFCAPKA----VSAARAHLPAAWKNLPATPET
FAPSSSVF-PAT----SQFQPASLNAFKGPSAASE----TPKSLPYAL---QDPFACVEA
LPAVPWVPQPNMNASKASQAMPTLLV-ATAAAPQ----A-TATT-QE---ASKTSVEPPR
RS-----------------------GKA--------------------------------
--TRK-----KKHLEAQE-DSRGHTLA-------------------------------FH
--D-WQGP----RPWENLN--LSDW--EVQSPVQ-V--LGDWEHPNTPCGLSGWEGPSTS
-RI---------------LSG---WEGPSTSWALSAWEGPSTSR-A--------------
---------LGLS---------------ESPGSSLPVVVSEVA-------------S---
VSPGSSATHDNSKVE-ARPLSPL---DERANALVQ------FLLVKD-QAKVPV--QR--
------------------------------------------------------------
----SEM---VKVIIREYKDECLDIINRANNKLECAFGYQLKEIDTKNHAYI-IINKLGY
HTGNLV-ASYLDR-PKFG---LLM----------VVLSL----------IF--------M
-KGNC----V-R--EDLIFNFLFKLGLD--VRETNGLFGNTKKLITEVFVRQK-------
---------YLEYRRIPYTEP---A--EYEFLWGPRAFLETSKMLVLRFLAKLHKK---D
------PQSWPFHYLEALAECEWEDTDEDE-PDT--G--DSA-------HGP--------
---TSRPPPR--------------------------------------------------
------------------------------------------------------------
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---------------------------------------MAQKMDCGAGLLGFQA-----
--------------------------------------------------------ETSV
EDST-LLMQTLM-------EAIQ--ISEAQPTSQAT--AA--------------------
------------------------------------------AASGQNASPQCSQLPTA-
S------------------------------------------------EMAD-------
------VQVSAAAARPKT------------------------------------------
-----------------------------AF---------------KTQ-----------
-------------NAT----------------TKVPDGVHSLSQAHDATEIS-STQPKAA
F-------------------KPQNATP--KGPNAAYD-------FCQAAAT---------
----GELATSKSEVALSEGQDVTTKVGPNA---------T-SSFSRSPCANEMATNQPKT
------------------------------------------------------------
----------------------------------------------AFKAWNDTTKAPTA
-------------------------------DTQT-------H--SQNI-----------
----NQA---KSATSQ--------ADTETN--PS---------IFEPDGAAAQTSADGSL
AQNLE--------------------S---------------------------------R
TIIRGKRTRKINNLNV---------EENSSSDQRRAPLAAGTWRSAPVPMTT-QNPPGAP
PNVLWQTPLA----WQNPS----GWQNQAARQTP----P-TRQNPPARQTPPSWQNPIAW
QNPVIWPNPVIWQNPVIWPNPI-VWPGPVVWPNPMAWQNPPGWHTPPGWQNTPGWHGPPD
WHG---PSDWPLPPDW-PLPP-DWPFP-TDWPLPPDWIPADWPIPPDWQNLRPSPNLRH-
-SPNSRASQNLAAPQ-PRDVALL---QERANKLVK------YLMLKD-YTKVPI--KR--
------------------------------------------------------------
----SEM---LRDIIREYTDVYPEIIERACFVLEKKFGIQLKEIDKEEHLYI-LISTPE-
SLAGIL-GTTKDT-PKLG---LLL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPLLGDLRKLLTYEFVKQK-------
---------YLDYRRVPNSNP---P--EYEFLWGLRSYHETSKMKVLRFIAEVQKR---D
------PRDWTAQFMEAADEALDALDAASA--EAEAR----AEARTRMGIGDEAV-----
------SGP--WSWDDIEFELLT-WDEEGDFGDPWS-RIPF----TFWARYHQNARSRFP
QTFAG---------------------P--IIGPGGTTSA------NFTANFGAIGF----
--------FWVE------------------------------------------------
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---------------------------------------MSDT-----------------
---------------SE-SGA----------------------------GLTSFQAEASE
KDSS-SMMQTLL-------TVTQ--NVEVPETPKAS------------------KA----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------PEVSEDVKVS-------KTSGVS---------------KAT-----------
-------------EV---------------------------SKTPEAQEAP-ATQASST
-TQLTDTQVLAA----EN--KSLAADT--KKQNADPQ-------AVTMPAT---------
----ETKK-----VSC--------------------------------------------
------------------------------------------------------------
--------------------------------------------------------VA--
-------------------------------DTKV-------------------------
----N-T--KA-----------------------------------------QSQENQDT
RPKVK--------------------A---------------------------------K
KARKVKHLDGEEDGS---------------SDQSQASGTTGGRRVSKALMASMARRASRG
PIAFWARRAS----RTRLA----A------------------------------------
------------------------------------WARRALL----SLRSPKARRGKAR
RRA---------------------------------------------------------
-AKLQS-SQEPEAPP-PRDVALL---QGRANDLVK------YLLAKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LKDIIKEYTDVYPEIIERAGYSLEKVFGIQLKEIDKNDHLYI-LLSTLEP
TDAGIL-GTTKDS-PKLG---LLM----------VLLSI----------IF--------M
-NGNR----S-S--EAVIWEVLRKLGLR--PGIHHSLFGDVKKLITDEFVKQK-------
---------YLDYARVPNSNP---P--EYEFFWGLRSYYETSKMKVLKFACKVQKK---D
------PKEWAAQYREAMEADLKAAAEAAA--EAKAR----AEIRARMGIGLGSE-----
----NAAGP--CNWD-------------EADIGPWA-KARIQAGAEAKAKAQESG--SAS
SGASTST------NNSA--SA--SAST--SGGFSAGASLTATLTFGLFAGLGGAGASTSG
SSGACG-FSYK-------------------------------------------------
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--------------------------------------MPRSQK---SKLRYREKR-HQA
-RE-----ETQGP-----------------------------------------------
-HG-------------AQASVEVK------------------------------------
-----------------------------------------------------------E
-GAP-------------------------SSPSA-----V---------------SGGSP
QSSP-A-------------------------AGH----------------PEEPPR---S
L--SPLTLAAVV--S--GPRAEEEA----ERP------------SSP-EAPGSPQ-SPGS
PEAPGSPQS--PG---------------------------VPQSPGS----PE-----TL
GSPEAPGSPEAPGSPEATG----SPEAPGSP---------------EG-L-SSPEALGSP
EATGSFQTCSAPQMWRSLQTWSSPQTC--SP-LQTWGATRHSRRDPLSRKAALVL-----
-------QFLLNKYKLKQPIL-KADML--KLIRRKYK-----EQFPEILRMCSER-----
----LELVFGLD---------LKE-HDASA---------QSYL-----------------
-------L----------------------------------VSKLDP--SE----TNLS
----GGWGLPRNGLL-------LPLLGVIFLNGNC------APEE---EIWQFLSLL---
-----GVY-KGR----RHFIFGDPWKLITRDLVRA------KYVEYRQV-AQSSPPRYEF
----LWGPRAHAVTS--KMKVLEFLAKVNDTVPS----A-FHSHYEE---ALKDEEERAQ
ARAA--------------------------------------------------------
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--------------------------------------MPRGQK---SKLRAREKR-RQA
-RS-----EAQGV-----------------------------------------------
-QD-------------AQATAAAE------------------------------------
-----------------------------------------------------------E
-QPP-------------------------TSPFP-----P---------------FGGAK
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------S-Q-DE-ERP---
-----------------------------ST-SQAQPSTDHYRRTPLDEKAILLV-----
-------QFLLRKYNMREPLT-KEDMM--KYVIKKHK-----EHFHEILRKASEL-----
----MVLGFGID---------LKE-VNPTR---------HCYA-----------------
-------L----------------------------------VSKFQC-TCD---DDRLR
----GEEIMPKTGLL-------MTILCVIFMKGNH------ATEE---DIWEVLNVM---
-----GIY-AER----KHFIYGDPKMFITQDLVRE------RYLQYHQV-ANSDPPRCEF
----LWGPRAHAETS--KMKVLEFLAKIHDTVRS----A-FPSWYEE---ALREEEEQAR
DR-FAALLHTG-AL----------------------------------------------
----------------------------------------------------------AS
--------------------VRP--R-----------------------ANFG-SFSHM-
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---------------------M-------SLVSQNARQ----------------------
------------------------------------------------------------
------------------SSAETT------------------------------------
-----------------------------------------------------------A
-DY---------------------------------------------------------
-----------------------------------------------------------S
N--SQGEMQA----------------TNASGP------------A-T-------------
---------------------------------------------------SM------L
----------ALEAPQ----GPEIPNDPQGA---------------SASQ-AV-------
---------RDP----S--DIEV--LID-EQSRRLGA---LRVHDPLEERSVALV-----
-------NFMRMKSQNEGSIR--QSEM--LEFLKEYS-----DQFPEILRRASAH-----
----LDRVFGLN---------LRV-LDPQM---------DTYN-----------------
----------------------L-------------------ISKPGP-QTT----ERLA
----ETLDIPKAGLL-------ALVLGHILLNGNR------AREA---SIWDLLLKV---
-----DVI---DGSQRINNQFGNTRNLLTIDFVHM------RFLEYWPV-YGTNPLEFEF
----LWGSRAHS--EITKM-----------------------------------------
------------------------------------------------------------
--------------------------E-------------------------------AL
K-----------------------F---VA----------------EAHDEEP-------
------------------------WSWPE-EYN------------KALEADKAKER---S
---------------------------------------------------------QA-
AG---L--------E-FWSED---TMNDKANELVQ------LAIGVT-EELLPI--HQ--
------------------------------------------------------------
----DEL---FANTGKEFQDVFPNILSRATLILDLFYGFSLIEVDTSEHIYL-LVPQPES
EEEQVM-LESLGR-PTQE---YLM----------PILGL----------IF--------L
-MGNR----V-K--EAKIWNLLQRFSVD--VGRKHAI--------TCKLMRQR-------
---------YLECRPLSYSNP---V--EYELLWGPRAHHEITKMKALEYMARFYGK---Q
------PQDWPEQYREAVE-----------DEEARARSEATAMFF----FGS--------
---I--------------------------------------------------------
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------------------------------MPR---------------------------
----------------------GQKSK-------------------------------LN
ARE--------------------RRH-RARNYAQA---SEGAEETVVATEESS-PKSCG-
--------------------------------------TSEMPE-K------------KS
---------VSTV---T-------------VDLFSIS--D-DS---------FIDL----
EDAEDLFRD--YHTI-S-HQDIL---TQKVFVLVQ------ILLKNY-KTKQLT--TI--
------------------------------------------------------------
----EDM---MQVIDEEEMDDFPEILRKAAERLADVFAVELREVESSRRVYD-LISKLKL
PNNGRV-RAGQGF-PKTG---FLM----------TVLGI----------IF--------M
-NGNC----A-G--EEDIWRTLRSMGIY--SGKKHQIFGEPRKLITQNFVKLK-------
---------YVECRQVANSKP---P--RYEFLWGPKAYAETNKMAILKFVAKVNEI---S
------PSYFKDLYKEALKDDQGKNQGNHN-VSSAIHLKD-RAFS----FVMCPRLAFSN
VEV---------------------------------------------------------
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----------------------------------------SDT-----------------
---------------SE-SGV----------------------------GSACFQTKASE
KDN-----------------VIQ--NLEVSETPKAL------------------KA----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------PEISETAKVS-------KALGVL---------------KAM-----------
-------------KV---------------------------SKAPEAQEAP-ATPSSST
-TQLTDTQVLTA----ET--KSPAADT--KTQNTDLQ-------AVTMPAT---------
----ETKK-----VRE--------------------------------------------
------------------------------------------------------------
--------------------------------------------------------SG--
-------------------------------YSAQ-------------------------
----GQG-----------------------------------------------------
------------------------------------------------------------
----------------------------------------QESPKGEALMASMAKRASKG
PIDFWAHRVA--------------------------------------------------
-----------------------------------------LV----SLRSPKAHRVKAH
------------------------------------------------------------
-------CRAPKVLP-PRDVALL---QGRANDLVK------YLLAKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LKDINKKYTNVYPEIIEQAGHSLEKVFGIQLKETEKNDHLYI-LLSTLEP
TDAGIL-GTTKDS-PKLS---PFM----------VLLSI----------IF--------M
-NGNW----S-N--EALIWEVLRKLGLR--PEIHHSLFGDVKKLITDEFLQ---------
--------------------S---P--EYEFFRGLRSYYEISKMKVLKFACKVQKK---D
------PKEWAAQYREAMEANLKAAAEAAV--EAKVR----AEIRAQMGIEHGSE-----
----NAAGP--CNWD-------------EADIGPLG-KAWIQAGAEDKAKAQESG--GAS
ASASTGM------------STSASTSA--SGASSASASLTATLTFGLFMGLGGACVSTSG
NSG--G-FSYK-------------------------------------------------
------------------------------------------------------------
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------------------------------------------

------------------------------------------------------------
------------------MSL--VSQNSRRRRGGRAN---AR------------------
--------------------RNNGKGHPAAVPGPDVPRDRNDPKILQ-GLRAS-------
---EG-----------------PGT------------SMLPT------------------
---------------PREGPSA---------SVPPTAS---EGSSAPRQFII-SQG-PNT
SEMPTS---------------R-KG----RGASRPPAVS---------------------
-----AGLNTAMSITASEGPN------SPVPPTAPKGSKA---YE-------HLPVSEGL
AI----------------------SE-QRHSDGGP--NMEPTL--------GEGPGISVP
PTFSEESGIS------------------------DEGLSIF-------MS--PNISEGPG
INEPYSVSEDPS--------TS---VP-----PTDSNG------------LG---INLPP
T------FGEGLSISMLFSALEEPDIFAPPPSA---------------EGLFAS------
------------------------------------------------------------
------------------------------------------MSPPSGEIQSSWVSPIIM
EGCNVNV---------PPTSKKGLRTSVP---------------SAACESPST-------
------------------------------------S---------------AEGLSSSL
----------SSI----------------------------------------------S
AEGFCSS---------LAP-----------------------------------------
------------------------------------------------------------
---C------------------------AAEG--SCELLP---------------CGEGR
STSE---LHCL------GEGSS-TSQMSLAAEGPSA--S---G---M---PT--------
---------------------------EANNP----------------------------
------EEALSCCA------SER--RNKSTSRALQK------------------------
-----------------------AKDPSVRP---------------K-------------
-------REDRFLDFQVLRDSKNSNSITIMGLGTSRVALTLKPQDPMEQNVAELL-----
-------QFLLLKDQTKYPIK-ESDMR--EFIDKDYR-----HQFPEILRRAAVH-----
----LECIFRFE---------LKE-LDTEE---------HIYI-----------------
-------L----------------------------------LNKLGPVPFE-----GLE
----DVPNGPKMGLL-------MMILGHILLNGNQ------AREA---DIWEMLWRF---
-----GVQ-RER----RLSVFGNVKRLLSVEFVWQ------RYLDYRPL-TDCVPVEYEF
----YWGPRSRAETT--KMKILKFMAKIYNKDPM----D-WPALYNE---ALEEDADRVV
VNN---------------------------------------------------------
------------------------------------------------------------
----FRVARPFRRPLFAE----------VAPE------------------LDA-S-----
------------------------------------------------------------
--------------------------------------G---------------------
---------SKYSPH-SWPESRL---ESKARKLVQ------LFLLMD-STKLPI--PK--
------------------------------------------------------------
----KGI---LYYIGRECTKVFPDLLNRAARTLNHVYGTELVVLDPRNHSYT-LYNRREM
EDTEEI-MDSPNR-PGNN---FLM----------QVLSF----------IF--------I
-MGNH----A-R--ESAVWAFLRGLGVQ--NGRKHVI--------TCRYLSQR-------
---------YLDSLRVPDSDP---V--QYDFVWGPRARLETSKMKALRYVARIHRK---E
------PEDWPEQYREAMEDEANRAEAGRR-PL----------IVRNLR-----------
------------------------------------------------------------
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------------------------------------------

------------------------------------------------------------
------------------MSQ--LSKNLGDSSPPAEAPKPP-------------------
----------VYSRPTVLMRAP-----PASSRAPPVPWDPPPIDLQA-SLAAWQAPQPAW
EAPQGQLPAPV---VPMTQPPALGGPIVPAPPLGGPMGKPPT------------------
---------------PGVLMVHP-PPPGAPMAQPPTPGVLMVHPSAPGAPMAHPPP-PGT
PMSHPP-------------------------PPGTPMAH---------------------
-----P---------P------------------PPGTPM----A-------HPPPPGTP
------------------------MVHP--PPPGTPMAHPPPPGTPMAHPPPPGTPMAHP
PPPGTP--MA-------------------HPPPPGTPMAQP---PAPGVLMAQPLTPGVL
MVQPA-------------APGAPMVQPP----PAAMM-------------------TQPQ
PSGAPMAKPPGPGVLMIHPPGARAPMTQPPASG---------------APMAQPAAPPAQ
PMAPPAQPMASWAPQAQPLILQIQSQVI----R-------APPQV---P-----------
-------Q---GPQAPPAQLATPPGWQATSPGWQATQQGWQATPLTWQTTQVTWQAPA--
----------VTWQVPPPM-RQGPPPIRP-------------GPPPIRPGPPPVR---QA
PPLIRQ---APPVIRQAPP-VIRQAPPVIRQAPA-------VIRQAPPVIRQAPPVIRQA
-PP---------V-----------------------------------------------
--------IRQAPPLIRQAPP-PI------------------------------------
-----------------------------------------------------------R
--------------PAPQVLATQPPLWQALPPPP-----P---------------LRQAP
QARLPAPQVQA------------APQVPTAPPATQ-------VPAAPPAGPQVPQP---V
L--PAPLSAP----------------------------------------LSA-------
----------P-----------QAVH--CPSIIWQAPKGQPPVPHE--------------
------------------------------------------------------------
------------------------------------------------------------
---------IPTSMEFQEVQQ-TQ-AL--AWQAQKAP-----THIWQPLPAQEAQRQ---
----APPLVQLE-------QPFQGAPPSQKAVQIQL-PPQQAQAS--GPQAEVPTLPLQP
SWQAPPAVLQAQPGPPVAAANFPLGSAKSLMTP-SGECRASSIDRRGSS-KE----RRTS
SK--ERRAPSKDRM----------IFAATFCAPKA----VSAARAHLPAAWKNLPATPET
FAPSSSVF-PAT----SQFQPASLNAFKGPSAASE----TPKSLPYAL---QDPFACVEA
LPAVPWVPQPNMNASKASQAVPTFLM-ATAAAPQ----A-TATT-QE---ASKTSVEPPR
RS-----------------------GKA--------------------------------
--TRK-----KKHLEAQE-DSRGHTLA-------------------------------FH
--D-WQGP----RPWENLN--LSDW--EVQSPIQ-V--SGDWEHPNTPRGLSGWEGPSTS
-RI---------------LSG---WEGPSASWALSAWEGPSTSR-A--------------
---------LGLS---------------ESPGSSLPVVVSEVA-------------S---
VSPGSSATQDNSKVE-AQPLSPL---DERANALVQ------FLLVKD-QAKVPV--QR--
------------------------------------------------------------
----SEM---VKVILREYKDECLDIINRANNKLECAFGYQLKEIDTKNHAYI-IINKLGY
HTGNLV-ASYLDR-PKFG---LLM----------VVLSL----------IF--------M
-KGNC----V-R--EDLIFNFLFKLGLD--VRETNGLFGNTKKLITEVFVRQK-------
---------YLEYRRIPYTEP---A--EYEFLWGPRAFLETSKMLVLRFLAKLHKK---D
------PQSWPFHYLEALAECEWEDTDEDE-PDT--GD--SA-------HGP--------
---TSRPPPR--------------------------------------------------
------------------------------------------------------------
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---------------------------------------MSDT-----------------
---------------SE-SGA----------------------------GLTSFQAEASE
KDSS-SMMQTLL-------TVTQ--NVEVPETPKAS------------------KA----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------T-----------
-------------EV---------------------------SKTPEAQEAP-ATQASST
-TQLTDTQVLAA----EN--KSLAADT--KKQNADPQ-------AVTMPAT---------
----ETKK-----VSC--------------------------------------------
------------------------------------------------------------
--------------------------------------------------------VA--
-------------------------------DTKV-------------------------
----N-T--KAQETEA--------AASQAPADEP---------EP--ESAAAQSQENQDT
RPKVK--------------------A---------------------------------K
KARKVKHLDGEEDGS---------------SDQSQASGTTGGRRVSKALMASMARRASRG
PIAFWARRAS----RTRLA----A------------------------------------
------------------------------------WARRALL----SLRSPKARRGKAR
RRA---------------------------------------------------------
-AKLQS-SQEPEAPP-PRDVALL---QGRANDLVK------YLLAKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LKDIIKEYTDVYPEIIERAGYSLEKVFGIQLKEIDKNDHLYI-LLSTLEP
TDAGIL-GTTKDS-PKLG---LLM----------VLLSI----------IF--------M
-NGNR----S-S--EAVIWEVLRKLGLR--PGIHHSLFGDVKKLITDEFVKQK-------
---------YLDYARVPNSNP---P--EYEFFWGLRSYYETSKMKVLKFACKVQKK---D
------PKEWAAQYREAMEADLKAAAEAAA--EAKAR----AEIRARMGIGLGSE-----
----NAAGP--CNWD-------------EADIGPWA-KARIQAGAEAKAKAQESG--SAS
TGASTST------NNSA--SASASTST--SGGFSAGASLTATLTFGLFAGLGGAGASTSG
SSGACG-FSYK-------------------------------------------------
------------------------------------------------------------
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---------------------------------------MSEA-----------------
---------------SE-SGT----------------------------DQTCFQTKASE
KVSG-LEMKTSL-------SATQ--NLEVSKTTKTS------------------KA----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------PEVSEVMKVL-------NAAGVS---------------KVT-----------
-------------EV---------------------------SKAPEAQKAA-ATQASPT
-TKLTDTQVLAA----EK--KSPAADT--KTQNADPK-------AVKMPVT---------
----ETKK-----DSC--------------------------------------------
------------------------------------------------------------
--------------------------------------------------------VT--
-------------------------------DKKV-------------------------
----N-A--KTLETEA--------TAAQAPADES---------EP--EGAAVQAQETLDT
RPKVK--------------------A---------------------------------K
KARKXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-------X-XXXXXXXXXXXXXX-XXX
XXXXXXXXXX----XXXXX----X------------------------------------
------------------------------------X----XX----XXXXXXXXXXXXX
XXX---------------------------------------------------------
-XXXXX-----XXXX-XXXXXXX---XXXXXXXXX------XXXXXX-XXXXXX--XX--
------------------------------------------------------------
----XXX---XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXX
XXXXXX-XXXXXX-XXXX---XXX----------XXXXX----------XX--------X
-XXXX----X-X--XXXXXXXXXXXXXXXXXXIHHSLFGDVKKLITDEFVKQK-------
---------YLDYARVPNSSP---P--EYEFFWGLRSYYETSKMKVLKFACKVQKK---D
------PKEWAAQYREAMEADMKAAAEAAA--EAKAR----AEIRAQMGIGLGSE-----
----NAAGP--CNWD-------------EADIGPWA-KSRIQAGAEAKAKAQESGEA--S
--------------------AGASVSP--NGGFTANTSLTATLTLGLFSGLGGAGASTSG
SSGACG-FSYK-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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--------------------------------------MPRGQK---SKLRAREKR-QET
-HG-----QPQGL-----------------------------------------------
-TG-------------PQATAEKQ------------------------------------
-----------------------------------------------------------E
-ESH-----------------------SSSSSSH-----D---------------CLGTR
RRSS----------------------------DAS-------V-------PQESQG---V
S--PTGSPDAVVSCSKSDVAA----KGQDEKS------------ASTSLEASIPQESQ-G
ASPTGSPDADVSC---------SKS--------DVAVKGQDEKSPSTSPDASI-----SQ
ESQGASPTG---FPDAGVS----GSKYDAAA---------------KDQ---DEESV---
-----------------------------RA-SQKAIIFKRLTQDPLKRKACALV-----
-------QLLQEKFEKKESIL-KADML--RRVGKRYK-----HYFPEILNRTSER-----
----LAVAFGVE---------LKE-MDSSG---------ESYT-----------------
-------L----------------------------------VSKLGL-SSE----GILN
----DAKGLQKSGLL-------MSVLSVIFMKGNR------ATEE---EVWEFLSCL---
-----GIY-AGM----THPIYGDPQKLITEDLVQD------KYVVYRQV-CNSDPPRYEF
----LWGPRAHAETT--KMRVLHVLAKSNKTSPG----L-HPHLYED---ALMDEVERAL
RLRA--------------------------------------------------------
------------------------------------------------------------
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--------------------------------------MPHGQ-----------------
-----------------KHD-QG-LQ-A----------------QREP----Q-----D-
-------------MAD--------------------------------------------
---------------------------------------------------EQIR-----
--V---------------------------------------------------------
---------------------------------------------------------ANE
VGTEEV------------------PT----------------------------------
---------AE--------------------------------------TP---------
-SPHESAQ------KAC-S--SSTTKSSE----------------VSKVL-KEQD-P---
------------R------TSQARP------------HSHFLFH-ILMQKVAEVV-----
-------KFLGVKYTTKEPIT-KAEIM--KKVIKEHK-----YYFPMIFKNVCDY-----
----MEVVFGIE---------VKE-VDATN---------HAYE-----------------
-------L----------------------------------VKIIDL-TYD----GRFS
---DD-QGIPKTGLL-------MLILGVIFMEGNR------APEE---KIWEVLRKI---
-----DIY-SDK----HDFMCTNPKKFIFEELVQE------QYLECNLV-PESDPPCFEL
----LWGPRAHAEAS--KMKVLKFFSKITGSNPT----E-YVALYRE---ALRDEEERAH
QAAA--AMADP-------------------------------------------------
------------------------------------------------------------
-----------------------AA------KGS----------------DGS--S--A-
------------------------------------------------------------
---------KPR---------------------TK-------------------------
------------------------------------------------------------
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--------------------------------------MPRGQK---SKLRAREKR-HQA
-RI-----EAQRA-----------------------------------------------
-QD-------------AQATAAEE------------------------------------
-----------------------------------------------------------E
-QPS-------------------------TSSFS-----P---------------SGGSA
Q-----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------S-Q-DE-EKP---
-----------------------------ST-SQAQPNTGRYHRTPLDDKAILLV-----
-------QFLLRKYNMREPIT-QEDMI--KHVIKKHK-----VHFREILRKASEL-----
----MVLAFGID---------LKE-VDPTR---------HHYA-----------------
-------L----------------------------------ISKLQR-TND----DRLR
----GEEIMPQTGLL-------MTVLCVIFMKGNC------ATEK---DMWEVLNVM---
-----GIY-ANK----KHFIYGDPKKLITEVWVQE------RYLLYRQV-SNSNPPCREF
----LWGPRAYAETS--KMKVLEFLATVHDTVPS----A-FPSWYEE---ALQDEEERAQ
AR-FTAQVHTG-AL----------------------------------------------
----------------------------------------------------------AT
--------------------GPS--M-----------------------ANSG-SFSHLY
------------------------------------------------------------
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--------------------------------------MSHI-P----------------
-----------------KSQ-GLEIP-G----------------ARKT----EES-AQS-
-------------WLDTMVSSAEE------------------------------------
-----------------------------------------------------------E
E-KG-----------------------T--------------------------------
------------------------------------------------------------
----------SL----EST--SEEE---Y---------------------VLE-------
----------T--------------------------------------PSAP-------
QNSPEVYH---IYTLIQ-A--IPCSHPGE----------------S-SSS-QEGEGS---
------------A------S----------------------QADQLDKKVAELV-----
-------KFLSFKYRIKEPIT-KAEML--TNVIKEQE-----AHFPIIFNKVCEC-----
----MEVVFGLE---------VKE-VDASS---------HSYE-----------------
-------L----------------------------------HKILDL-TYD----GMLN
---D--NSLPKTGLL-------ILILGVIFMEGNV------ASEE---KVWEVLSMI---
-----GVC-AGR----RDFIYGEPRKLITKDLVQE------RYLEYRQV-ADSDPPSYEF
----LWGPRACAETT--KMKVLQFFSKVSGTVPT----S-FPSRYEE---ALRDELERAQ
ARIAALHLTGP-------------------------------------------------
------------------------------------------------------------
-----------------------RE--------D----------------SSSVESGSE-
------------------------------------------------------------
---------SGG---------------------AKSC-----------------------
------------------PE----------------------------------------
------------------------------------------------------------
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--------------------------------------MSLG-Q----------------
-----------------KSE-CCKLE-E----------------DLQA----PKE-AQG-
-------------LECVQASMAQK------------------------------------
-----------------------------------------------------------E
E-AT-----------------------SCP------------------------------
------------------------------------------------------------
KSTISSSLTLLI----PGT--TEEV---P---------------------ATG-------
----------A--------------------------------------LIVV-------
QNSQGACS---SPTATS-A--TPLSQSDE----------------N-SSS-QEEKEP---
------------SN------CKTPP------------DPESSLGGELNNKVAELV-----
-------QFLCIKYVTKEPTT-KAEML--RSVIREHK-----DNFPEIFSKVCKC-----
----MEVVFGIE---------VKE-VDPMG---------HSYE-----------------
-------L----------------------------------VKTLNL-TYD----GMLI
---N-DGGMPKTGFL-------ILILGMIFMEGNC------APEE---NIWKALNMM---
-----GVY-AGQ----EDFIYGEPRKLITKDLVEE------QYLQYRQV-PHSDPPRYEF
----LWGPRAYAETS--KMKVLEFFAKISGADPT----S--LFWYEE---ALRDER--AQ
ARTVPWDDTTT-------------------------------------------------
------------------------------------------------------------
-----------------------MA--------S----------------ENS----SA-
------------------------------------------------------------
---------MSS---------------------NLFC-----------------------
------------------PE----------------------------------------
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--------------------------------------------------MLQKPE---S
E--------------------------------------------------ALPIL----
-------QAE----------------------------GEKDGGR-GETQALT-----A-
-SQKEVPNPLLQE----------TPKENLGA---------------RREE-G--------
----------------AAESALTPKGV--RT-LAAKALARRRAYRRLDRTVAELV-----
-------QFLLVKDKKKSPIT-RSEMV--KYVIGDLK-----DLFPEIIARAAEH-----
----LRYVFGFE---------LKQ-FGRKH---------HTYI-----------------
-------L----------------------------------INKLKPLEEE----EE--
EEDDLGGDGPRLGLL-------IMILGLIYMKGNS------ARET---QVWEMLRRL---
-----GVR-PSK----YHFLFGYPKRLIMEDFVQQ------RYLNYRQV-PHTNPPECEF
----SWGPRSNLEIS--KMKVLGFVAKLHKKEPQ----H-WPVQYRE---ALADEADRAR
AKAR-AERKKTDLH----------------------------------------------
------------------------------------------------------------
-LY---------------------------------------------------------
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--------------------------------------------------------MAE-
----------------------------------------------------------GS
SP-----M-E-------SECCNVEDMEDGLEEVR--EYEMFDGNEYE----EFGAFGGYG
TFTSFDIHL--LRAFGSLG-----------------------------TSLRVLANEPWE
LDHP-MLARTLV-------DAFR--ADPEPAPNEEDDQSG-------------NAGRGDS
NRAA----------RTA-ARAAA----------------RAAAAAARALYNQV---VTS-
R------------------------------------------------PMAT-------
------DQASREDTQAMASS------------------------------------PH-S
-----SQMPGNSEMAASGAPAT-SSQPQPGS---------------QAR-----------
-------------EA-------------------------ASSRAPGASEVD-ATQPKKP
FLGQ----------------------------NDGFD-------FTQPAGV---------
----SGIAFPRPKRPAPAPEP--APEGPSA---------------QAASAGEGAATRPKT
A-----------------------------K-----------------------------
------------------------------------------------------------
--------------------------------------------------------SGKA
LAKTRWVEPQNVVAAA--------AAKA-KMATS---------APEPEGAAAT--AQNNR
DE-----------------------P---------------------------------W
ARMGGKRTKK-KHLDDEY--------ESSE-EEREPPVVPPTWRASQPPLTVRAQMA---
---------P----R---------------------------------------------
----------------------------------------AQMG----------------
-----------------PRPP-----------------------------M----A----
-VRPQVPSRHILCLP-PRNVALL---QDRANKLVK------YLMIKD-YKKIPI--KR--
------------------------------------------------------------
----SDM---MKDVIREYDEHFPEIIERATYTLEKKFGIHLKEIDKEEHLYI-LTCTRDS
SAR-LL-GKTKDT-PRLS---LLL----------VILGV----------IF--------M
-NGNR----V-S--EAVLWEALRKMGLR--PGVRHPFLGDLKKLITNDFVRQK-------
---------YLEYKKVPNSSP---P--EYEFFWGLRARYETSKMRVLRFIAQYQNR---D
------PRDWKAHFLEAVDDAFKTMDADMA--EEHAR----AQMRARMNIGDEAL-----
------IGR--WSWDDVQVELLT-WDEDGDFGDAWA-RIPF----AFWARYHQYILNSNR
ANRRT------TWRAGVSSGNIGAANASLIDGPSTS-ST---IRSRNAARTT--------
----ANFFSWIQ------------------------------------------------
------------------------------------------------------------
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--------------------------------------------------------MAE-
----------------------------------------------------------GS
FG-----V-Q-------SESYSVEDMDEGSDEVR--EEEMVEGNDYE----EFGAFGGYG
TLTSFDIHI--LRAFGSLG-----------------------------PGLRILSNEPWE
LENP-VLAQTLV-------EALQ--LDPDTLANETAARAA-------------NVARAAA
---S----------NRA-ARAA--------------------AAAARTAFTQV---VASH
R-------------------------------------------------VAT-------
------PQVSGEDTQPTTYAA--EAQ--------------------GPTPEPPLASPQTS
------QMLVTSEMAAPGAPVT-STKSQTGS---------------PAQ-----------
-------------EAA----------------TEGPSSACAFSQAPCAREVD-TTRPSTA
FLGQ----------------------------NDVFD-------FTQPAGV---------
----SGMAFPRPKRPAPAQEG--ATEGSSA---------AS-GVPQTGPGREVAATRPKT
T-----------------------------K-----------------------------
------------------------------------------------------------
--------------------------------------------------------SGKA
LAKTRWVEPQNVVAAA--------AAKA-KMATS---------IPEPEGAAA--ATAQHS
AE-----------------------P---------------------------------W
ARMGGKRTKKSKHLDDEY--------ESSE-EEREPPAVPPTWRASQPSLT---------
---------V----R---------------------------------------------
----------------------------------------AQLA----------------
-----------------PRRP-----------------------------V----A----
-PRSQIPSRHVLCLP-PRNVTLL---QERANKLVK------YLMIKD-YKKIPI--KR--
------------------------------------------------------------
----ADM---LKDVIREYDEHFPEIIERATYTLEKKFGIHLKEIDKEEHLYI-LVCTRDS
SAR-LL-GKTKDT-PRLS---LLL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPFLGDLRKLITDDFVKQK-------
---------YLEYKKIPNSNP---P--EYEFLWGLRARHETSKMRVLRFIAQNQNR---D
------PREWKAHFLEAVDDAFKTMDVDMA--EEHAR----AQMRAQMNIGDEAL-----
------IGR--WSWDDIQVELLT-WDEDGDFGDAWA-RIPF----AFWARYHQYILNSNR
ANRRA------TWRAGVSSGTNGGASTSVLDGPSTS-ST---IRTRNAARAG--------
----ASFFSWIQHR----------------------------------------------
------------------------------------------------------------
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--------------------------------------MPRGQK---SKHRAREKH-RQA
-RA-----ETQGL-----------------------------------------------
-HD--------------QATTSGG------------------------------------
-----------------------------------------------------------E
-ETT-------------------------SSSPP-----D---------------SESGP
SSSS-A-------------------------AGT----------------SKGPQG---A
Q--GTTSAAAGAVRKRSGVGRA--------------------------------------
------------------------------------------------------------
--------ARSRSGVGAAA----CSRSGIGA---------------EG-Q-VREGE----
-----------------------------NS-SQASAAAESSHTDLLTRKAGVLV-----
-------QYMLYKYQVRERIK-RSEML--KAVTRRYR-----EQFPEILSRASER-----
----MELVFGLV---------LKE-VRPNS---------HCYT-----------------
-------L----------------------------------VSNLDL-SDS----ESMR
----GDWGLPKNGLL-------MPLLGVIYLNGHH------ASEE---EIWKFLNIL---
-----GIY-DGR----SHFIFGEPRKLITEDLVQE------GYLEYNLV-PGSDPPRYEF
----LWGPKALTETS--KTKVLQFLTKVNDLVPN----A-LLPYYEE---AWREEIESTR
ARAAA-GTGPSALAS-----TG---PSASARSG---------------------------
-----------------------TSA----------------------------------
-P--------------------ARAGPSVSARAGP-----LA------------------
------------------------------------------------------------
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---------------------------------------MAQKPDGGAGLRGYQA-----
--------------------------------------------------------EASV
EDSA-LLVQTLM-------EAIQ--IS-EAPPTNQA--TA--------------------
------------------------------------------AASGQNVSPQSSQPPTA-
N------------------------------------------------QVAD-------
------TGVSTAAARPKT------------------------------------------
-----------------------------GF---------------RAQ-----------
-------------NTF----------------SKGPN---DFSHARNAKEMS-KNQSKAA
Y-------------------KSHNGTS--KGPNAASN-------FSHGATT---------
----GKSAAKKSEIAFKVQNTT-TKAGPGA---------T-YNFSQSPSANEMINNQPKT
------------------------------------------------------------
----------------------------------------------ATKAWNDTTKVPAA
-------------------------------DAQI-----------QNV-----------
----NQA---KMANVG--------T------SPG---------ISETGGAAAQTSADGSQ
AQNVE--------------------S---------------------------------R
TIIRGKRTRKINNLNV---------EENSSGDQRRASLASGNWRSAPVPVTT-QNPPGAP
PNVLWQTPLA----WQNPS----GWQNQTARQAQ----P-ARQNPPARQTATAWQNPVAW
QNPVIWPNPVIWQNPVIWPNPI-VWPGPIVWPNPMAWQNAPGWQTPPSWQAPPSWQGPQD
WQG---PPDWQIPPDW-SLPP-DWSFS-TDWPFPPDWIPADWPIPPDWQNLRPSPNLRS-
-TPNARASQNQGAPQ-PRDVALL---QERANKLVK------YLMLKD-YTKVPI--KR--
------------------------------------------------------------
----SEM---LRDIIREYTDVYPEIIERACFVLEKKFGIQLKEIDKEEHLYI-LISTPE-
SLAGIL-GTTKDT-PKLG---LLL----------VILGI----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPLLGDLRKLLTYEFVKQK-------
---------YLDYRRVPNSNP---P--EYEFLWGLRSYHETSKMKVLRFIAEVQKR---D
------PRDWTAQFMEAADEALDALDAAAA--EAEAR----AEARTRMGIGDEAV-----
------SGP--WSWDDIEFELLT-WDEEGDFGDPWS-RIPF----TFWARYHQNARSRFP
QAFTG---------------------P--IIGPSGTATA------NFAANFGAIGF----
--------FWVE------------------------------------------------
------------------------------------------------------------
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-----------------------------------SCAGSDEG-------------AQGP
EEESAGASHAAPATQ-SPHKNPL---TRRASMLVE------FLLEKY-TQKEPI--L---
------------------------------------------------------------
----------LKVVGRKYKQHFHEILRRACKHMELVFGLEMMEVDCSRNIYA-LIKKLNL
WGDEGP-SEEGGL-PKSG---FLM----------VLLGI----------IF--------M
-KGNH----A-P--GEEAWEL-SVLGVY--TGRKHCIFGEPRKLITKDLVQKK-------
---------YLKYRQVPNSDP---P--RYEFLWGPRACARTPKFFLLGLLREVRGA---M
------SISYTYLYDEALRHQAERVGLRGM-ARAPTMAEASAPSRAKSY------SSSH-
------------------------------------------------------------
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----------------------------------MDRRKDYGYRMPTFQSKHPNGEERS-
GSNYRRIPWGRRPPP-PRDVAIL---QERANKLVK------YLLVKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LKDVIQEYDEYFPEIIERASYALEKMFRVNLKEIDKQSSLYI-LISTQES
SAG-IL-GTTKDT-PKLG---LLM----------VILSV----------IF--------M
-NGNK----A-S--EAVIWEVLRKLGLR--PGVRHSLFGEVRKLITDEFVKQK-------
---------YLEYKRVPNSRP---P--EYEFFWGLRSYHETSKMKVLKFACKVQKK---D
------PKDWASQYREAVEMEVQAAAVAVA--EAEAR----AEARGHPPLQIPLI-----
------SSSS-ISME--------------------S-RYSF----GIFIHS---------
------------------------------------------------------------
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---------------------------------------------------METQIRREG
LGCSPASIKRKK-KEDSG--HLGLQVSTMFSEDDFQST---EGAPSGPQI----------
---------QWSQDLPRVQVFRE----------QANQE---DRSPR-RTQRITGG-EV--
-----------------LWGPITQVFPTVWPADLTGVIMPLEQ-----------------
-----------------RSQ-HCKPE-E----------------GLQA----QED-NPG-
-------------LVGGAQALQAE------------------------------------
-----------------------------------------------------------E
Q-E---------------------------------------------------------
------------------------------------------------------------
---AASFSSTLN----VGT--LEE------------------------------------
---------VP--------------------------------------ATES---SGPP
QSPQGESS---SPTAMD-S--IFGSLSDE----------------GSSS--QEEEGP---
------------S------TSPDLI------------EPESFSQDILHDKIINLV-----
-------HLLLRKYRVKGLIT-KAEML--GSVIKNYE-----DYFPEIFREASEC-----
----MQLLFGID---------VKE-VDPTS---------HSYV-----------------
-------L----------------------------------VTSLSL-SYD----GIQG
---DE-QSMPKSGLL-------IIVLGVIFMEGNC------VPEE---VMWEVLSIM---
-----GVY-AGR----EHFLFGEPKKLLTHDWVQE------KYLVYRQV-PATDPACYEF
----LWGPRAHAETS--KMKVLEYIAKANGRDPS----S-YPSLYED---ALREEEERV-
------------------------------------------------------------
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--------------------------------------MSLEQ-----------------
-----------------RSP-HCKPD-E----------------DPEA----QRE-DLG-
-------------LMGAQDPTGEE------------------------------------
-----------------------------------------------------------Q
E-A---------------------------------------------------------
------------------------------------------------------------
---TSSS-D---------E--EEE------------------------------------
---------VS--------------------------------------AAGS---SSPP
QSPQGGSS---SSTSVY-Y--TLWSQFDE----------------GSSS--QEDEGP---
------------S------TSVDLA------------HLEFMFQEVLKLKVAELV-----
-------RFLLHKYRVKKPVT-KAEML--ESVIKNYK-----HYFPVIFGKASEF-----
----MQLIFGTE---------VKE-VDPAG---------PSYI-----------------
-------L----------------------------------VTALGL-SCD----SMLG
---ND-HSMPKAALL-------IIILGVILTKDDC------APEE---VIWEALSVM---
-----GVY-VGM----EHVFYGEPRKLLTQDWVQE------NYLEYRQV-PGSDPAHYEF
----LWGSKAHAETN--YEKVINYLVMVNAREPI----C-YPSLYEE---AFGGEQEGV-
------------------------------------------------------------
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--------------------------------------MSLEQ-----------------
-----------------RSP-HCKPD-E----------------DLEA----QGE-DLG-
-------------LMGAQDPTGEE------------------------------------
-----------------------------------------------------------Q
E-T---------------------------------------------------------
------------------------------------------------------------
---TSSSDNK-----------EEE------------------------------------
---------VS--------------------------------------AAGS---SSPP
QSPQGGAS---SSTSIY-Y--TLWSQFDE----------------GSSS--QEEEGP---
------------S------TSVDPA------------HLEFMFQEALKLKVAELV-----
-------RFLLHKYRVKEPVT-KAEML--ESVIKNYK-----HYFPVIFGKASEF-----
----LQLIFGTD---------VKE-VDPAG---------HSYI-----------------
-------L----------------------------------VTALGL-SCD----SMLG
---DG-HSMPKAALL-------IIILGVILTKDNC------APEE---VIWEALSVM---
-----GVY-VGT----EHIFYGEPRKLLTQDWVQE------NYLEYRQV-PGSDPAHYEF
----LWGSKAHAETS--YENVINYLVMVNAREPI----C-YPSLYEE---VLGEEQEGV-
------------------------------------------------------------
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--------------------------------------MPRGHK---SKLRSREKR-RQA
-FG-----DTHSV-----------------------------------------------
-NS-------------AQATAAEE------------------------------------
-----------------------------------------------------------E
-RSP-------------------------SSSSP-----S---------------FGGPP
QSFP-A-------------------------VRT----------------PQGSQR---G
P--STTTAA-AG------------------------------------------------
------------------------------------------------------------
-----------------TS----GRRAPRGA---------------EG-Q-DE-GGP---
-----------------------------S---SARAPNERSRRDPLTRRVIMLS-----
-------QFLLSKYEMQERIT-KGKMM--KIINKRYK-----EHFPEILRRASEY-----
----IELVFGLD---------VKE-VDSKG---------QSYT-----------------
-------L----------------------------------VSKLEI-TEE---ENL-S
----GGRGFPKTGLL-------MPLLAMISMNGNR------ATEE---EMWEFLNVF---
-----GMY-DGK----THFIFGEPRKLLTKDLVQA------KYLEYRQV-PNSDPPCYEF
----LWGPRAQAEAS--KTKVLEFSDKVQDTNSG----A-FQALYKE---AWGDEEETAT
GG-EWAGACPE-AR----------------------------------------------
----------------------------------------------------------AG
--------------------SSD--R-----------------------ESAA-GPPILS
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--------------------------------------MEPTD-----------------
-----------------NSQ-NFNLW-D----------------IPQA----QIE-DRG-
-------------PEDAQGP----------------------------------------
------------------------------------------------------------
--------------------------------------IAEA------------------
------------------------------------------------------------
---GEVEAIATI----SGD--V--------------------------------------
----------S--------------------------------------AGEE---PSSP
Q---RASS---PPTAMG-F--IG-----------------------------EASFG---
------------N------PLAGMP------------GTEFPVHGELNGKIVDLV-----
-------RFLLVKFRRMEITS-KEEMI--HRTMRDYE-----EHYSVIFSKAAEC-----
----MKLIFGVD---------MME-VDPFV---------HSYF-----------------
-------L----------------------------------YPALGI-TYD----GM--
LH-GV-VGVPKTGLV-------IIVLCIIFIEDNC------VSEE---VFWHVMNSL---
-----GMY-AGV----DHFIFGDPRSLITEDFVQE------GYVEYRQV-PNSHPPRFEF
----LWGPRAYAETT--KMKILEFYASIVRQDPR----S-YPEKYAE---ALREEQERA-
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--------------------------------------------------MLQTPE---S
G--------------------------------------------------GLPVP----
-------QAE----------------------------GEKDGGHDGETRAPT-----A-
-SQE-------------------RPKEELGA---------------GREE-G--------
----------------AAEPALTRKGA--RA-LAAKALARRRAYRRLNRTVAELV-----
-------QFLLVKDKKKSPIT-RSEMV--KYVIGDLK-----ILFPDIIARAAEH-----
----LRYVFGFE---------LKQ-FDRKH---------HTYI-----------------
-------L----------------------------------INKLKPLEEE----EE-E
EEEDLGGDGPRLGLL-------MMILGLIYMRGNS------AREA---QVWEMLRRL---
-----GVQ-PSK----YHFLFGYPKRLIMEDFVQQ------RYLSYRRV-PHTNPPEYEF
----SWGPRSHLEIS--KMKVLGFVAKLHKKEPQ----H-WPVQYRE---ALADEADRAR
AKAR-AEASMRARA--------SARA------G---------------------------
------------------------------------------------------------
-IH----L------W---------------------------------------------
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--------------------------------------MSQD-Q----------------
-----------------ESP-RCTHD-Q----------------HLQT----FSE-TQS-
-------------LEVAQVSKALE------------------------------------
-----------------------------------------------------------K
T-----------------------------------------------------------
------------------------------------------------------------
---LLSSSHPLV----PGK--LKEA---P---------------------AAK-------
----------A--------------------------------------ESPL-------
EVPQSFCS---SSIAVT-T--TSSSESDE----------------ASSNQ-EEEDSP---
------------S------SSEDTS------------DPRNVPADALDQKVAFLV-----
-------NFMLHKCQMKKPIT-KADML--KIIIKDDE-----SHFSEILLRASEH-----
----LEMIFGLD---------VVE-VDPTT---------HCYG-----------------
-------L----------------------------------FIKLGL-TYD----GMLS
---GE-KGVPKTGLL-------IIVLGVIFMKGNR------ATEE---EVWEVLNLT---
-----GVY-SGK----KHFIFGEPRMLITKDFVKE------KYLEYQQV-ANSDPARYEF
----LWGPRAKAETS--KMKVLEFVAKVHGSYPH----S-FPSQYAE---ALKEEEERAR
ARI---------------------------------------------------------
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--------------------------------------------K---------------
-------------PCTQKSQ-ACKLE-E----------------GLQA----QSE-TQG-
-------------Q----------------------------------------------
------------------------------------------------------------
-WLC---RF------CS-------------------------------------------
------------------------------------------------------------
----SFSTSFLI----SGN--LEE------------------------------------
---------VS--------------------------------------AAEM---LSTP
QGPQCAYS---CSTVQA-A--APYQVS--------------------SL--QGEEGP---
------------C------NLQIQP------------ESESLLRDEIDDKVVDLV-----
-------MFLLQ---VKKPFT-RAEIL--EAIIKNHQ-----DHFSVIFGEASEC-----
----LQLVFGID---------VKK-VDPAS---------QCYV-----------------
-------L----------------------------------ISMLGL-IYN----GILS
-D--S-QSMPKTGLL-------VTILGVILLEGNC------PTEK---EIWELLSVM---
-----GVY-PGR----KHCIYGKPRKLLIRDWVWE------GYLEYQQV-PGSEPVCSEI
----LWGPRAHAEAR--KMKVLEVLAKVYGTIPS----T-FPTWYEE---ALKDEEDRAM
S-----------------------------------------------------------
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--------------------------------------MPLRHTS---------------
-----------------QLW---KL--------------------EED----PGE-AQG-
-------------LVNAQLPEAED------------------------------------
-----------------------------------------------------------E
DEVSSPPYL------CS---------SSS----------------------------SSP
SSSSSC------------------------------------------------------
-SSPSLSSSGLF----FVP--PEEG-----------------------------------
---------SE----------------------------------------TA---WSPP
QSPQSAGP---SPSGRA-P--SGWSQVEF----------------AGPSG-PEEEIW---
------------N------PWEVPE----------YAQPSAQGGDTMLMSGADLV-----
-------GFLLRKYLNKQPTS-QAEVL--EVLSPDMQ-----DAWPEIWGQACEC-----
----MQLVFGVE---------VKE-VDPIA---------HSYV-----------------
-------L----------------------------------VTVLGL-SYD----GMLS
-G--E-QGLPTTGLL-------VLLLGVILLEGDR------APEQ---EVWEALGVM---
-----GVF-AGR----QHVIYGEPRELLTHVWVQE------GYVEYRQV-AGSNPARYEF
----LWGPRAHEETS--KLRVMEYVLWVNSRWPV----S-SLAPFDE---EEWA------
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--------------------------------------MPLSP-----------------
-----------------KRP-RFSFE-L----------------DFEA----PFE-FQ--
------------------------------------------------------------
-----------------------------------------------EWDQVHIP----S
SEEVSSSSS------SS---------------TSSSYSSSS-------------------
---------------------------------------------------------SSS
SSSSPS--ILVL----ESS--EEEEF-SD-------------------------------
-----KILS------------------------------------------------PPQ
ISSSICSS----------S--ISWSISDE----------------EPNNQ-NVEVCS---
------------S------TLQSLI------------DTEYFLKDPLEGKVTDLV-----
-------HFLIVKYRSKEHIT-KEEML--QVIA-QSH-----SQFPVILKKASKC-----
----LQVIFGID---------VEE-VDLTG---------HSFA-----------------
-------L----------------------------------VNSLNL-TYV----EVPG
VG-DN-PGMPKNGLL-------IIVLGVIFIEGNC------ASEE---SIWDFLNMM---
-----GLY-AGS----EHFIYGEPRKLITVDWVQE------NYLEYRQV-LYSDPPQYEF
----LWGPRAHAETS--KMKVLEFLARVKGSDPT----S-FSGWYEE---ALMDEQERAQ
AEVSSVHSDAS-------------------------------------------------
------------------------------------------------------------
-----------------------TS------SVQ----------------YWS--E----
------------------------------------------------------------
----------AS---------------------SCSN-----------------------
------------------EE----------------------------------------
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--------------------------------------MPRGQK---SKLRAREKR-RQA
-RG-----ETQSL-----------------------------------------------
-RG-------------AQATGAAA------------------------------------
-----------------------------------------------------------E
-E---------------------------SPSSP-----V---------------SGGTP
PSSP-A-------------------------AGT----------------PQEPQG---A
P--VTSSPDA-G------------------------------------------------
------------------------------------------------------------
-----------------VS----CPRSDEGA---------------KS-Q-DE-QNA---
-----------------------------ST-SQAATSTQSTHKDPLTRKVSMLV-----
-------QFLLEKYKMKEPIV-QAALL--KIVNKKYK-----EHFPEILRRSSEH-----
----LELVFGLE---------LKE-VDPSN---------HVYI-----------------
-------L----------------------------------VSKLGL-LG---NESL-S
----SDKGLPKTSLL-------MTLLGVIFMKGNR------ATEE---EIWEFLNVL---
-----GVY-AER----KNLIFGEPRKLITKDFVQE------KYLEYRQV-PNSDPPCYEF
----LWGPRAYAETN--KMKVLEVLAKINDTVPT----A-FPNLYEE---ALRDEEERAG
V-----------------------------------------------------------
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---------------------------------------MSET-----------------
---------------SE-SGA----------------------------GPTRFQGKASE
KDSG-SMMQDLL-------PATQ--NLEVSETPKAE------------------KA----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------PEVSEAAKVP-------KASGNP---------------KAT-----------
-------------EV---------------------------SKAPEDSEAA-ATQPSTT
-TQLTDTQVLAA----EN--KSPAADT--KTQKADLQ-------AMTMPAT---------
----QTKK-----VSC--------------------------------------------
------------------------------------------------------------
--------------------------------------------------------VT--
-------------------------------DPKV-------------------------
----S-T--KAPETEA--------ADSQAGADEP---------EP--EGAAVQVQENQDT
RPKVK--------------------A---------------------------------K
NTQKVKHLDGEEDGNSGNSGNSGNSGNSGNSDQSQASETTGGRRVSKALMASMARRASRG
PIAFWARRAS----RTRLA----A------------------------------------
------------------------------------WARRALL----SLRSPRARRGKAR
RRA---------------------------------------------------------
-AKLQSASQEPEAPP-PRDVALL---QGRANELVK------YLLAKD-QTKIPI--RR--
------------------------------------------------------------
----SDM---LKDIIKEYTDVYPEIIERAGYSLEKVFGIQLKEIDKSDHLYI-LLSTLEP
TDAGIL-GTTKDS-PKLG---LLM----------VLLSI----------IF--------M
-NGNR----S-S--EAVIWEVLRKLGLR--PGIHHSLFGDVKKLITDEFVKQK-------
---------YLDYARVPNSNP---P--EYEFFWGLRSYYETSKMKVLKFACKVQKK---D
------PKEWAAQYREAMEADLKAAAEAAA--EAKAR----AEIRAQMGIGLGSE-----
----NAAGP--CNWD-------------EADIGPWA-KARIQAGAETKAKA--QESGGAS
AGASTG----TSVGTGASASASASAGA--SGGFSTSSNLTATLTFGLFAGLSGAGASSSS
SSGACG-FSYK-------------------------------------------------
------------------------------------------------------------
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------------------------------MPP---------------------------
----------------------GQKSK-------------------------------LH
DRE--------------------KCH-QTCGENQN---LETAQATVAEGDSLS-SAN---
-LL-------------------EGGRPHN-LPTSGTTSIPKELQ-G-------------A
---------PSTT---S-------------TTVTVLCTNSNED-------------I---
NSKDEKSSNSSRKTE-DTFKDPF---SKKVVLLVQ------FLLQKY-QEKEPI--TK--
------------------------------------------------------------
----GGM---LKYVIK-HYKYFNEIHKRASEHIELVFGVDLREVDPIRHCYT-FFNKLDT
TYDVLM-SDEESM-PKTG---LLM----------IVLGV----------IF--------M
-NGNC----A-P--EEAIWEVLNLMGVY--ADRKHFVYGDPRKVITEDLYYPQ-------
---------CLPI-------P---G--SYSCH--GQQHSRVTASNFSHAK----------
------------------------------------------------------------
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--------------------------------------MLLRQ-----------------
-----------------KRQ-SCKAE-E----------------GRQA----QGD-APG-
-------------LMDVQILTTEE------------------------------------
-----------------------------------------------------------Q
K-A---------------------------------------------------------
------------------------------------------------------------
----ASSSSTLI----AGT--LEE------------------------------------
---------VP--------------------------------------DSGS---LSPA
QSPRGASS---SLTVTD-D--TLWSQSNE----------------VSSS--NEEEGP---
------------S------TSPDPA------------HLESLFREALDEKVAELV-----
-------HFLLRKYQIKEPVT-KAEML--ESVIKNYK-----NHFPEIFSKASEC-----
----MQVIFGID---------VKE-VDPAG---------HCYV-----------------
-------L----------------------------------VTCLGL-SYD----GLLG
---DD-Q------------------------------------KE---AIWEALSVM---
-----GLY-DGR----EHSAYWELRKLLTQDWVQE------NYLEYHQV-PGSDPVRYEF
----LWGPRALAETS--YVKVLEHVARVNARVRI----S-YPSQSNR---CEATGESGGV
YMP---------------------------------------------------------
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-------------------------------------------MS---------------
-------------LCD-KFM-AFTLE-D----------------ENQD----PQD-DQH-
-------------LKNGQESPS-S------------------------------------
-----------------------------------------------------------S
------------------------------------------------------------
------------------------------------------------------------
------TASVLL----EDT--TGE------------------------------------
---------VA--------------------------------------AAGV---FSVP
KGPHQSSQPV-ISRTMA-A--TPENHPLE----------------GASSR-QE--KR---
------------L------RS---------------QPKLGCLQKALDDKISDLV-----
-------GFLLLKYRTKQLTT-KEAML--RTIPNNDE-----EDFSVILSQVSEC-----
----MHLVYGID---------VKE-VDPI----------HSYA-----------------
-------L----------------------------------VTTLGL-TYD----GMVG
-P--Q-QTMPNTGLL-------VMVLGVILLEEDC------ASEQ---AVWEQLSLM---
-----GVY-PGR----KHFIYGEPRKLLTNVWVQE------QYLEYQQV-PGSIPARFQF
----LWGPRAHAETS--KMDVLDFLINVYISEQK----S-LQCVSQA---MLEEEKEWA-
------------------------------------------------------------
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--------------------------------------MPPPPKR---------------
-------------LCYKKCW-CCILK-D----------------NLQS----QSE-NWG-
-------------LWNAQVPQCEE------------------------------------
-----------------------------------------------------------E
REHTSSSSS------SS---SSSSSSSSSSSSSSSSSSSSS--SSS---SSSSSSSSSSS
SPSSSC---------------------------------------SSS---SSSSSSSSS
SPHPTSSFCFLT----PGT--TIEV-----------------------------------
---------PD--------------------------------------TAGT---PSPF
QASQRVWT---LPTALA-T--TPSIISDQ----------------GSGS--RKRKRP---
------------S------TSQALP----------D--GGHLLRDAIDGKVGDLV-----
-------SFLLVRYHRKEVAT-KAEML--S-VIKDYQ-----DLFPMILSQATDC-----
----MNLVFGID---------VKA-LDPTG---------LFYV-----------------
-------L----------------------------------VNTLGL-TYN----DSLS
-G-DE-ESMPMAGLL-------VNTLSIIFIAGNC------APEE---KIWEMLGIM---
-----GLY-AGM----NHFIYGDPRELLTQVWVQQ------GYLEYRQV-PNSDPACYEF
----LWGPRTYAETT--KMKVLEFLAKVHDTIPS----A-FPSLYEE---ALQSEKTGPQ
ARVVARARARD-------------------------------------------------
------------------------------------------------------------
-----------------------GT------CAR----------------TRA--YSKA-
------------------------------------------------------------
---------TSN---------------------SFFC-----------------------
------------------PN----------------------------------------
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-------------------------------------------MNQGL-TYD----GMMH
----GEAGVPKVGIL-------ILILGVIFMKGNC------ATEE---EVWEVLNVT---
-----GLY-PGK----KHFIFGEPKQLITEDFVRE------GYLEFRQV-ASADPAQSEF
----LWGPRAHAETT--KMKVLKFIAKVHGTDPS----S-FPSQYEE---ALQDEKEKAQ
ARIS-AKGLRH-SKF---------------------------------------------
------------------------------------------------------------
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--------------------------------------------------MLQKPR---G
R--------------------------------------------------GRPST----
-------QAD----------------------------REREWGDA--------------
----------GEE----------APSTSRGT---------------GGTS-Q--------
------------------GSR---------A-SLSSPAVGPRTQKQLEVKVAELV-----
-------QFLLIKDQKKIPIK-RTDIL--KHVVGDYR-----DVYPNLLRLAAER-----
----LQYVFGYK---------LVE-LEPKS---------HTYI-----------------
-------L----------------------------------INMLEPVEED----AEVR
----GDQGTPTTGLL-------MIVLGLIFMKGNT------ITET---EVWDFLRRL---
-----GVE-ATK----KHLIFGDPKKLITEDFVRQ------RYLEYRRI-PHTDPVDYEL
----QWGPRTNLETS--KMKVLKFVAKVHNQDPK----D-WPTQYCE---ALADEENRAR
PAAS-APTTSS-------------------------------------------------
------------------------------------------------------------
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---------------------------------------MAQKPDGGAGLRGFQA-----
--------------------------------------------------------EASV
EDSA-LLVQTLM-------EAIQ--IS-EAPPTSQA--TA--------------------
------------------------------------------AASGPNASPQSSQPPTA-
N------------------------------------------------EKAD-------
------TEVSAAAARPKT------------------------------------------
-----------------------------GF---------------KAQ-----------
-------------NAT----------------TKGPN---DYSQARNAKEMP-KNQSKAA
F-------------------KSQNGTS--KGPHAASD-------FSQAAPT---------
----GKS-AKKSEMAFKGQNST-TKAGPGA---------T-YNFPQSPSANEMTNNQPKT
------------------------------------------------------------
----------------------------------------------A-KAWNDTTKVPGA
-------------------------------DAQT-----------QNV-----------
----NQA---KMADVG--------T------SAG---------ISEADGAAAQTSADGSQ
AQNVE--------------------S---------------------------------R
TIIRGKRTRKVNNLNV---------EENNSGDQRRASLASGNWRSAPVPVTTQQNPPGAP
PNVVWQTPLA----WQNPS----GWQNQTARQTP----PAARQSPPARQTPSAWQNPVAW
QNPVIWPNPVIWQNPVIWPNPI-VWPGPIVWPNPMAWQSTPGWQSPPSWQAPPSWQSPQD
WQG---PPDWQVPPDW-SMPP-DWSFP-SDWPFPPDWIPADWPIPPDWQNLRPSPNLRS-
-SSNSRASQNQGPPQ-PRDVALL---QERANKLVK------YLMLKD-YTKVPI--KR--
------------------------------------------------------------
----SEM---LRDIIREYTDVYPEIIERACFVLEKKFGIQLKEIDKEEHLYI-LISTPE-
SLAGIL-GTTKDT-PKLG---LLL----------VILGI----------IF--------M
-NGNR----A-T--EAVLWEALRKMGLR--PGVRHPLLGDLRKLLTYEFVKQK-------
---------YLDYRRVPNSNP---P--EYEFLWGLRSYHETSKMKVLRFIAEVQKR---D
------PRDWTAQFMEAADEALDALDAAAA--EAEAR----AEARNRMGIGDEAV-----
------SGP--WSWDDIEFELLT-WDEEGDFGDPWS-RIPF----TFWARYHQNARSRFP
QAFTG---------------------P--IIGPSGTATA------NFAANFGAIGF----
--------FWVE------------------------------------------------
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----------------TLPQ----------------A-------RG----------SSS-
-------------------PIFCPHSVT----VRARVIMPGHHMN---------------
-----------------EPL---KPE-E----------------DFPY----PIE-IPH-
-------------LMAEQLFWAMQ------------------------------------
-----------------------------------------------------------E
EEEEEEED-------VL---SLSS------------------------------------
------------------------------------------------------------
------SPSVLF----IDN--LEE------------------------------------
---------VS--------------------------------------AAET---PSPP
QSPERACP---SPHAME-A--FPCSQPED----------------GSSSI-QDEEGP---
------------N------TEGGPE----------DDADSLLH-KALRSKMMEML-----
-------KFLLLKYRAKEPTT-KAEIL--SSVIKEHQ-----DHFPELFSAAVES-----
----IELVFGIV---------VTE-VDPST---------HTYV-----------------
-------L----------------------------------ATALGL-TYD----GMVS
-D--E-QKFPNTSLL-------VTLLCVIASQGDC------APEE---KIWAVLNDL---
-----GVH-DGK----VHWLYGEPRELITKVWVQE------QYLVYRQV-PNSNPARYEF
----LWGPRAHAETT--RAKALQFVAMAN-------------------------------
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------------------------------------------

------------------------------------------------------------
------------------MSL--VSQNSRRRRRRVAK---ATA-----------------
----------H-NSSWDEMQAPNAPGFPADMPGSDVPQGPSDSQILQ-GLCAS-------
---EG-----------------PST------------SVLPT------------------
---------------SAEGPST---------FVPPTIS---EASSASGQPTV-SEG-PGT
SLLATP---------------S-EG----LSTSGPPTIS---------------------
-----KGLCTSMTLAASEGRN------TSRPPTSSEEPST---S----------------
--------------------------V-----------------------------TSVV
PTPDEGPSTS-------------------V------------------------------
--------------------TS---VP-----PTATEG------------LST---PVPP
T------PDEGPSTSMPATPGEGRSTSMLPAAS---------------DGQSIS------
------------------------------------------------------------
------------------------------------------LVPNPGKGSSTSGPPTAT
EGLSTSV---------QPTAGEGQSTSV--------------------------------
---------------------------------------------------------TSV
----------PPT----------------------------------------------P
GEGLSTS---------VPPNAT--------------------------------------
-----------------------------------------------------------E
GLST--------------------------SVPP-----T---------------PGEGP
ST-SVLP-TPG------E-GRS-TSVPPT-ASD-GS--D---T-SVP---PT-PGE----
G--PSTLVQP----------------TASDRP--------------GSSVLPNP------
---GEGPSTLFSCSA-----SVDRNPSKCS-IVLPSPRVTKA------------------
----------------S------VDSDSEGP---------------K-------------
-------GAEGPIEFEVLRDCESPNSITIMGLSTSRVAITLKPQDPMEQNVAELL-----
-------QFLLVKDQSKYPIR-ESEMR--EYIVKEYR-----NQFPEILRRAAAH-----
----LECIFRFE---------LRE-LDPEA---------HTYI-----------------
-------L----------------------------------LNKLGPVPFE-----GLE
----ESPNGPKMGLL-------MMILGQIFLNGNQ------AKEA---EIWEMLWRM---
-----GVQ-RER----RLSIFGNPKRLLSVEFVWQ------RYLDYRPV-TDCKPVEYEF
----FWGPRSHLETT--KMKILKFMAKIYNKDPM----D-WPEQYNE---ALEEDAARAF
AEG---------------------------------------------------------
------------------------------------------------------------
----WQALPHFRRPFFEE----------AAAE------------------VAS-PD----
-SE---------------------------------------------------------
---------VSSY-------------------------S---------------------
---------SKYAPH-SWPESRL---ESKARKLVQ------LFLLMD-STKLPI--PK--
------------------------------------------------------------
----KGI---LYYIGRECSKVFPDLLNRAARTLNHVYGTELVVLDPRNHSYT-LYNRREM
EETEEI-VDSPNR-PGNN---FLM----------QVLSF----------IF--------I
-MGNH----A-R--ESAVWAFLRGLGVQ--SGRKHVI--------TCRYLSQR-------
---------YIDSLRVPDSDP---V--QYEFVWGPRARLETSKMKALRYVARIHRK---E
------PQDWPQQYREAMEDEANRADVGHR-QF----------FVHNFR-----------
------------------------------------------------------------
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----------------------------------MDRRNDYGYRVPTFQSKHPNGEERT-
GSNYRRIPWGRRPPP-PRDVAIL---QERANKLVK------YLLVKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LKDVIQEYDEYFPEIIERASYALEKMFRVNLKEIDKQSSLYI-LISTQES
SAG-IL-GTTKDT-PKLG---LLM----------VILSV----------IF--------M
-NGNK----A-S--EAVIWEVLRKLGLR--PGVRHSLFGEVRKLITDEFVKQK-------
---------YLEYKRVPNSRP---P--EYEFFWGLRSYHETSKMKVLKFACKVQKK---D
------PKDWAAQYREAVEMEVQAAAVAVA--EAEAR----AEARAQM------------
---------G-IGEE--------------------P-RYSF----GIFVHTAA-------
------------------------------------------------------------
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------------------------MNIE----LQASRN-MLSLPPAPAPPLRDP---TYE
R--MQCSSFSAS-------------------------------------KARSAVGSSSV
CSAEVV---YRTCPE-----------------------------------------PRCQ
HHLLAC----LLP---C-L-LC------------LLIVMPRGQK---SKRRAREKR-RQA
-RM-----ETKDL-----------------------------------------------
-GD-------------AQAAA---------------------------------------
------------------------------------------------------------
------------------------------SPAP-----T---------------SGSVP
PGPP-T-------------------------ADA----------------GQKPQG---A
E--ATTSPVA--------------------------------------------------
------------------------------------------------------------
----------------EAS----PPRSKARG---------------RR-Q-VKEHKN---
------------------------------S-SQASTSAKTTPPDLLAKKAGVLM-----
-------HFMLEKFKMKEPIR-KIDML--KIVRKMFK-----AQFPEILKKATDR-----
----IELVFGLE---------LKE-VKPNG---------YSYT-----------------
-------L----------------------------------VSKEGL-AKD----GVLG
----STLEVPKNGLL-------MPLLGVIFLNGNC------ASEA---EIWEFLNVL---
-----GIY-DGK----THIIFGEPRKFITEELVQE------KYLVYRQI-PDSDPLSYEF
----VWGPRAHAETS--KMEVLEFVAKINSTDPS----A-FPFHYEE---ALRDEEERAK
ARSA-GKA----------------------------------------------------
-----------------------------------------------------------H
--------------------AAAKA------------------------------TA---
------------------------------------------------------------
------------H-----------------------------------------------
------------------PKVPP---S-DPSSPQ--------------------------
------------------------------------------------------------
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---------------------------------------MDRRNDYGYRVPPFQ--G---
--------PLPPP--GSLGLP----------------------------LPPDIQTETTE
EDSV-LLMHTLL-------AATK--DSLAVDPPVVSRPKK-------------SKTKKAP
IKAI----------TKA-APA--APPVPTANEIATNKPKITLQALNLPVITQISQASPT-
T------------------------------------------------EVTN-------
------TQVSSVTAQPKKANKMKRVTAKAAQG-SQSPTGREGGATQLKSPLQVLNLPVIS
QNIHA---SIANESASSQTL-ITSIKPKKAS---------------KAK-----------
-------------KAA----------------NKAIASATEVSLAPTATHTA-TTQGQIT
-NETASIHTTAASIRTKKASKARKIIA--KVINTDTE-------HIQAANV---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------TETAT
RQIEA--------------------S---------------------------------V
IAIRPKKSKGKKAASRGP---------N------------SVSEISEALLATQMVTNQAL
AATLRVKRGS----RARKA----STKARATESQT----PNADQGAQAKMASAQ-TNVSAL
ETQ------------VA------------AAVQALADDYLAQL----SLEPTTRTRGKRN
RK-----------------------------------------------SKHLNGDERS-
GNNYRRIPWGRRPAP-PRDVAIL---QERANKLVK------YLLVKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LRDVIQEYDEYFPEIIERASYALEKMFRVNLKEIDKQSSLYI-LISTRES
SAG-IL-GTTKDT-PKLG---LLM----------VILSV----------IF--------M
-NGNK----A-S--EAVIWEVLRKLGLH--PGVRHSLFGEVRKLITDEFVKQK-------
---------YLEYKRVPNSRP---P--EYEFFWGLRSYHETSKMKVLKFACKVQKK---D
------PKDWAVQYREAVEMEVQAAAVAVA--EAEAR----AEARAQMGIGEEAV-----
------AGP--WNWDDMDIDCLT-REELGDDAQAWS-RFSF----EIEARAQENADASTS
VNFSRGAGTRAGFSDGASISFNGAPSS--S----G-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------GPGITFGGAPSSSASFSNTASISFGGTLSTSS----------------
--------------------SFS------------------S----------------AA
SISFGGAPSTSTSFSSEASISFGGTPCTSASFSGGVSSSFSGPLN--TSATFSGAASSGF
GG------------------TL-STTAGFSSVLSTSTSFGSAPTTNTVFSSALSTSTGFG
GTLSTSVCFGGSPSSSGSFGGTLSTSICFGGSPCTSTGFGG----TLSTSVSFGGPSSTS
ANCGGTLSTSICFDGSPSTG-AGFGGALNTSASFGSALNTS-------------------
-------------------------------------------------AGFGGAMSTSA
DFGSTLSTSVCFGGSPGTSVSFGSALNTSAGFGGAVSTSTDFGG----------------
------------------------------------------------------------
-----TLSTSVC------------------------------------------------
----------------------FGGSPSTSAGFSGALNTNASFGCAISTSAGFSGAVGTS
AGFSGVPSTNPGFGGAFNTSAGFGGALSTTTDFGGTPNNSIGFGAAPSTSVSFGGAHSTS
LCFGGAPSTSLCFGSASNTNLCFGGPPSTSACFSGATSPSFGDGPSTSTGFSFGNGLSTS
AGFGGGLNTSAGFGGGLGTSAGFSGD------------------------------LSTS
SGFDGGLGTSAGFSGGPGTSTGFGGGLGTSAGFSGGLGTGAGFGGGLVTSDGFGGGLGTN
ASFGSTLGTGAGFSGGLSTSDGFGSRPNASFDRGLSTIIGFGSGSNTSTGFIGEPSTSTG
FHSGPSSIVGFSGGPSTGVGFCSGPSI-SGFSGGPSTGAGFG------------------
------------------------------------------------------------
-------GGPNTGAGFGGG-PSTNAGFGSGATSLGACGFSYG

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------MSLEQ-----------------
-----------------RSQ-HCKPE-E----------------GLEA----QGD-ALD-
-------------LVGAQAPAPEE------------------------------------
-----------------------------------------------------------Q
E-T---------------------------------------------------------
------------------------------------------------------------
----ASSSSTVV----EVT--RGE------------------------------------
---------VP--------------------------------------AAES---LGPP
QSPQGAST---LPTTNN-Y--TLWSQSDE----------------DSSS--QEEEGP---
------------S------TFPDL---------------ESGFQAALSRKVAELV-----
-------HFLLLKYRAREPVT-KAEML--ESVMRNCQ-----YSFPVIFSKASDS-----
----LQLVFGIE---------LME-V DPVS---------HLYI-----------------
-------F----------------------------------ATCLGL-TYD----GLLD
---DN-QIMP KAGLL-------IIVLAIIAKEGDC------APEE---KIWEELNVL---
-----EVF-DER----QDGIFADPRKLLTQDFVQE------NYLEYRQV-PGSDPACYEF
----LWGPRALVETS--YVKVLYHMLKISGGPHF----S-YPPLHEW---ALREGEE---
------------------------------------------------------------
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------------------------------------------------------------
--------------------------------------MPRP-C----------------
-----------------KRR-RCMAE-G----------------ELEA----QSD-AP--
------------------VSIE-E------------------------------------
------------------------------------------------------------
V-DS-----------------------SSSSTCSSSFPSSFSSS----------------
-----------------------------------------------------------S
------SSYALT----SST--SEEG--F--------------------------------
----------V--------------------------------------ASRT---SSPS
HSPPGACS---SCTAMI-S--SPCSQFS-------------------AAS-EPEEGS---
------------G------SSEVMP------------CAASLSKGEIDVKVDELV-----
-------KYLLFKYLMKEPVT-KAEML--SNIIRNYQ-----DHFPLIFREASEC-----
----MQLVFGID---------MKE-VQPAG---------HTYI-----------------
-------L----------------------------------VTSLEL-TYD----GMMT
---DV-QGIPKTGLL-------IMVLSIIFMEGNC------ISED---MVWGVLNNI---
-----GLY-AGN----EHFIYGEPRKLITDDFVQE------GYLEYRQV-SGSHPPSYEF
----LWGPRAYAETT--KMKILTFLTNINGSDPR----S-YPVWYAE---ALRDEEERA-
------------------------------------------------------------
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---------------------------------------MSDT-----------------
---------------SE-SGA----------------------------DPARSQGKASE
KDSG-SVMQDLL-------TVTQ--NLEVSETPKAE------------------KA----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------PEVSEAAKAP-------KASGNP---------------KAT-----------
-------------EV---------------------------SKAPEASEAA-ATQASPT
-TQLSETQVLAT----EN--KSPAADT--KTQKSDLQ-------AMTMPTT---------
----PTKK-----VSC--------------------------------------------
------------------------------------------------------------
--------------------------------------------------------GT--
-------------------------------DPKV-------------------------
----N-T--KAPETEA--------PASQAGTDEP---------EP--EGTAVQVQENQDT
RPKVK--------------------A---------------------------------K
NTQKGKHPDGEEDGN---------------SDQSQASEATGGRRVSKALMASMARRASRG
PIAFWARRAS----RTRLA----A------------------------------------
------------------------------------WARRALL----SLRSPRARRGKAR
RRA---------------------------------------------------------
-AKLQS-SQEPEAPP-PRDVALL---QGRANDLVK------YLLAKD-QTKIPI--RR--
------------------------------------------------------------
----SDM---LKDIIKEYTDVYPEIIERAGYSLEKVFGIQLKEIDKNDHLYI-LLSTLEP
TDAGIL-GTTKDS-PKLG---LLM----------VLLSI----------IF--------M
-NGNR----S-S--EAVIWEVLRKLGLH--PGIHHSLFGDVKKLITDEFVKQK-------
---------YLDYARVPNSNP---P--EYEFFWGLRSYYETSKMKVLKFACKVQKK---D
------PKEWAAQYREAMEADLKAAAEAAA--EAKAR----AEIRAQMGIGLGSE-----
----NAAGP--CNWD-------------EADIGPWA-KARIQAGAETKAKAQGSGGANAS
AGAG--ASTGTSVGASA--SAGASAGA--SGGFSNNSSLTASLTFGLFAGLSGAGASTNS
SSGACG-FSYK-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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--------------------------------------MPHTQK---SNLCVREKR-QQK
-QA---------------------------------------------------------
-----------------------K------------------------------------
-----------------------------------------------------------E
-KFP-------------------------SSSAP-----P---------------FGCTT
QRKP-G------------------------AKSRS-------T-------LQGPQR---A
L--STRTTSP-G------------------------------------------------
------------------------------------------------------------
-----------------AS----RAKS----------------------K-GK-KRR---
-----------------------------SS-SQDQPSTKRSRRDPLTEKVGTLV-----
-------QFLVQKYKMKKLVM-KKDML--KIVNKKYK-----KRFLEILRRASFS-----
----MEVVFGIA---------LKE-IDSIK---------HSYA-----------------
-------L----------------------------------VSKMDL-PNN----GRLN
----CGRGLPKTGLL-------MILLGVIFMKGNC------ASEE---KIWEFLNKM---
-----KIF-AGK----RHFMFGEPRKLITQDFVKL------KYLEYRQV-PNSDPPSYEF
----LWGPRAHAETS--KMKILEFLAKINDTVPS----A-LPSLYEE---ALRDEEERAR
AT-VPDRADPT-AM----------------------------------------------
----------------------------------------------------------AS
--------------------VVRAPV-----------------------PGP---AAPPR
------------------------------------------------------------
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------------------------------MPR---------------------------
----------------------KHKNK-------------------------------QH
--------------------ARGKCH-QVQGDTQE---VQAS--AAAAPE-----EECT-
-SC---------------PSSAPQGSPPS-SP---AAADHQELQ-G-------------A
---------MAPS---S-------------PVAEASCAGSEEG-------------AQGP
EEES AYAARAALLAR-SIRKDPL---MRKASL VMD------FLLERY-TKKEPI--TQ--
------------------------------------------------------------
----SGM---LEIIGRKYKQHFPEILSRASERVELVFGLELKEVDCNKNIYT-LVNKFSL
GVEEGS-TDEEEL-PKSG---LLM----------ALLGI----------IF--------M
-KGNR----A-T--EEEIWDFLNVLGIY--AGKKHSIFGEPRKLITKDLVQKG-------
---------YLNYRQVPNSVP---P--GYEFLWGPRAYAETTKMKVLEVLAKIQDK---V
------PSSFPDLYDEALRDQVERAALRGV-ARIPIMAEASAPTRAKSY------SSSHI
------------------------------------------------------------
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--------------------------------------MPLEQ-----------------
-----------------RSQ-HCKPE-E----------------GLEA----RGE-ALG-
-------------LVGAQVPVTEK------------------------------------
-----------------------------------------------------------Q
E-S---------------------------------------------------------
------------------------------------------------------------
----ASSSSTLV----EVT--LGE------------------------------------
---------VS--------------------------------------AAD------PQ
----GAST---LPTIIN-C--TLWSQSDE----------------GSSN--QEEEGP---
------------S------TFPDL---------------ETGFQAALSRKVAELV-----
-------HFLLLK----EQFT-MAEIL--E-----------SYFFPVIFSKASEY-----
----LQLVFGIE---------VME-VVPIS---------HLYI-----------------
-------L----------------------------------VTCLGL-SYN----GLLG
---EN-QIMPTTDLL-------IIILATVAIEGDG------APEE---KVWEELSVL---
-----ELS-GRR----EDSVLANPSKLLTQVLVQE------NYLEYQQV-PFSDHACYEF
----LWGPRALVETN--YVKVLYHMLKITGEPRI----S-YPPLHEW---AWREGEE---
------------------------------------------------------------
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--------------------------------------MPVVQ-----------------
-----------------MGD-LHQTE-A--------------------------------
------------------------------------------------------------
-------------------------------------------------------D----
FQDP--------------------------------------------------------
R---------------------------------------------EAEDVVVAQEMANH
------------------------------------------------------------
--------------------------------------------------------EFCT
TXXXXXXX---XXXXXX-X--XXXXXXXXXXXXXXXXX-XXXXXXXXXXX-XXXXXX---
------------X------XXXXXX------------XXXXXXXXXFHLKAADLV-----
-------GFLLLKYRTKEPTT-KEDML--NAVLRADQ-----DHFPVVLSQASEC-----
----LQLLFGVD---------VKE-VDPRE---------HLYV-----------------
-------L----------------------------------VPTLGL-TCD----GM--
LG-GG-QSLPKNGLL-------VMLLGVILLEGEC------ATEE---KMWEALSVM---
-----GVY-PGR----EHCIYGEPRELITNVWVRE------EYVDYQQV-PSSDPPRYEL
----LWGPRAHAETS--KLQVLEHFLRVNTRNLC----S-FLSLSEE---VLSDEEEW--
------------------------------------------------------------
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--------------------------------------MAFPQ-----------------
-----------------KNP-QSSP-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------D
QLPQTH---------------------------------------SETQGLEVAQESKAL
EEASLS-SHPEM----PGN--LKE------------------------------------
---------AP--------------------------------------DAAI---PSTS
QSAQSSS----SSIVTT-V--SSSRKYGE----------------GSSRE-EEGD-----
------------S------TLEADP------------DPKNVPKDAEDENVASLV-----
-------NYLLFKYQIKAITT-IEDML--KIISKEYE-----DHFIEMFQRACER-----
----LEIIFGLD---------VKE-VDPYN---------HCYA-----------------
-------I----------------------------------FIKLGL-TYD----GM--
QH-GE-VGVPKTGIL-------ILILAVIFMRGNR------ATEQ---EIWDVLSVM---
-----GLY-SGK----KHYIFGEPRELITKYFVEE------EYLNYRKV-ANSDPAQFEF
----LWGPRAHAETT--KMQVLKFLAKVHGTIPC----G-FPSQYEE---ALRDEEERTR
AKPGSSSHTLD-------------------------------------------------
------------------------------------------------------------
-----------------------MY------SNI----------------GFS--I----
------------------------------------------------------------
---------SLS---------------------SF-KI----------------------
------------------SK----------------------------------------
------------------------------------------------------------
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--------------------------------------MPRGQK---SKHRAREKR-RQA
-RA-----EIQGL-----------------------------------------------
-HD--------------QATTSRG------------------------------------
-----------------------------------------------------------E
-ETT-------------------------SSSPP-----D---------------SESAP
SSLS-A-------------------------AGT----------------PKGPPG---A
Q--GTTSAAAGAIRKRSGGGGT--------------------------------------
------------------------------------------------------------
--------ARSRSGA---------------------------------------------
-----------------------------------SAAAESSHTDLLTMESENLV-----
-------KYMLLKYKMRELIK-RSEMV--KVIHRRYK-----VQFSEILSRASEH-----
----MEMVFGLV---------LKE-VRPNS---------HCYT-----------------
-------L----------------------------------VSNLDL-SDS----ESMR
----GDWGLPKNGLL-------MPLLGVIYLNGHR------ASEE---EVWKFLNIL---
-----GIY-DGR----MHFIFGDTRKLITENLVQE------EYLEYNQV-PGSNPPRYEF
----LWGPKALTENS--KTKVLQFLTKVNDLVPD----A-LLPHYEE---ALREEAERTG
ARAAT-GTGPSASAS-----AD---PSASARPG---------------------------
-----------------------TSA----------------------------------
-A----------------------------------------------------------
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--------------------------------------MPRGQM---STLHAREKR-QQT
-RG-----QTQDH-----------------------------------------------
-QG-------------AQITATNK------------------------------------
-----------------------------------------------------------K
-KVS-------------------------FSLPL-----I---------------LGATI
QKKS-A------------------------GRSGS-------A-------LKKPQR---A
L--STT-TSV-D------------------------------------------------
------------------------------------------------------------
-----------------VS----YKKSYKGA---------------NS-K-IE-KKQ---
-----------------------------SF-SQGLSSTVRSRTDPLTMETNMLV-----
-------QFLMEMYKMKKPIM-KADML--KIVQKSHK-----NRFPEILKKASFN-----
----MEVVFGVD---------LKK-VDSTK---------DSYV-----------------
-------L----------------------------------VSKMDL-PNN----GTVT
----RGRGFPKTGLL-------LNLLGMIFMKGNC------ATEE---KIWEFLNKM---
-----RIY-DGK----KHFIFGEPRKLITQDLVKL------KYLEYRQV-PNSNPARYEF
----LWGPRAHAETS--KMKVLEFWAKVNQSVPS----A-FQFWYEE---ALRDEEERVQ
AA-AMLNDGSS-AM----------------------------------------------
----------------------------------------------------------GR
--------------------KCSKAK-----------------------AGS---SSHA-
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--------------------------------------MSLEQ-----------------
-----------------RSL-HYKPE-E----------------AFEA----QQE-ALG-
-------------LVCVQA-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---AAASSSPLV----LGT--LEE------------------------------------
---------VP--------------------------------------TAGS---TDPP
QTPQGASA---FPTTIN-F--PRWRQPNE----------------SSSS--HEEEGP---
------------S------TSRVL---------------ESLFRAVLTKKVADLV-----
-------RFLLLKYRAREPVT-KAEML--ERVIKNYK-----HCFPVIFGKASES-----
----LQLVFGID---------VKE-ADSTG---------HSYV-----------------
-------L----------------------------------VTCLGL-SYD----GLLG
---DN-QIMPKTGFL-------IIILVMIAMEGGR------APEE---EIWEELNVM---
-----EVY-DGR----EHSAYGEPRKLLTQDLVQE------KYLEYRQV-PYSDPARYEF
----LWGPRALTETS--YVKVLEYVIKVSARVRF----F-FPSLREA---ALRQEGDEEG
V-----------------------------------------------------------
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------------------------------------------

------------------------------------------------------------
------------------MSL--VSQNSRRRRRRVAK---ATA-----------------
----------H-NSSWGEMQAPNAPGLPADVPGSDVPQGPSDSQILQ-GLCAS-------
---EG-----------------PST------------SVLPT------------------
---------------SAEGPST---------FVPPTIS---EASSASGQPTI-SEG-PST
SVLPTP---------------G-EG----LSTSEPPTIS---------------------
-----KGLCTSVTLAASEGRN------TSRPPTSSEEPST---SV-------PPTASEVP
-S----------------------TSLPPTPGKGTSTSVPPTA--------YEGPSTSVV
PTPDEGPSTS-------------------VPPTPGEGPGTS-------VP--LTATEGLS
TSVPATPDEGPS--------TS---VP-----PTATEG------------LST---PVPP
T------RDEGPSTSVPATPGEGPSTSVLPAAS---------------DGQSIS------
------------------------------------------------------------
------------------------------------------LVPTPGKGSSTSVPPTAT
EGLSTSV---------QPTAGEGPSTSVP---------------PTPGGGLS--------
---------------------------------------------------------T--
------------------------------------------------------------
------S---------VPPTAT--------------------------------------
-----------------------------------------------------------E
DLST--------------------------SVPP-----T---------------PGEGP
ST-SVLP-TPG------E-GLS-TSVPPT-ASD-GS--D---T-SVP---PT-PGE----
G--PSTLVQP----------------TAPDGP--------------GSSVLPNP------
---GEGPSTLFSSSA-----SVDRNPSKCS-LVLPSPRVTKA------------------
----------------S------VDSDSEGP---------------K-------------
-------GAEGPIEFEVLRDCESPNSISIMGLNTSRVAITLKPQDPMEQNVAELL-----
-------QFLLVKDQSKYPIR-ESEMR--EYVVKEYR-----NQFPEILRRAAAH-----
----LECIFRFE---------LRE-LDPEA---------HTYI-----------------
-------L----------------------------------LNKLGPVPFD-----GLE
----ESPNGPKMGLL-------MMILGQIFLNGNQ------AKEA---EIWEMLWRM---
-----GVQ-RER----RLSIFGNPKRLLSVEFVWQ------RYLDYRPV-TDCKPVEYEF
----FWGPRSHLETT--KMKILKFMAKIYNKDPM----D-WPEKYNE---ALEEDAARAF
AEG---------------------------------------------------------
------------------------------------------------------------
----WQALPHFRRPFFEE----------AAAE------------------VAS-PD----
-SE---------------------------------------------------------
---------VSSY-------------------------S---------------------
---------SKYAPH-SWPESRL---ESKARKLVQ------LFLLMD-STKLPI--PK--
------------------------------------------------------------
----KGI---LYYIGRECSKVFPDLLNRAARTLNHVYGTELVVLDPRNHSYT-LYNRREM
EETEEI-VDSPNR-PGNN---FLM----------QVLSF----------IF--------I
-MGNH----A-R--ESAVWAFLRGLGVQ--AGRKHVI--------TCRYLSQR-------
---------YIDSLRVPDSDP---V--QYEFVWGPRARLETSKMKALRYVARIHRK---E
------PQDWPQQYREAMEDEANRADVGHR-QI----------FVHNFR-----------
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--------------------------------------MPRGQK---SKLRAREKR-QRT
-RA-----QTQDL-----------------------------------------------
-KV-------------GQATAAEK------------------------------------
-----------------------------------------------------------E
-ESP-------------------------SSSSS-----V---------------LGDTP
SSSL-A-------------------------LGI----------------PQKPQR---E
P--RTTPAAAAMSGTG--------------------------------------------
------------------------------------------------------------
--------------------------PDEGE---------------ES-Q-DEENA----
-----------------------------SS-SQASTSTERSLKDPLTRKTKMLV-----
-------QFLLYKYKMKEPTT-KAEML--KIISKKYK-----EHFPEIFRKVSQR-----
----TELVFGLA---------LKE-VNPTT---------HSYI-----------------
-------L----------------------------------VSMLGP-TND----GNQS
----SAWSLPRNGLL-------MPLLSVIFLNGNC------AGEE---EIWEFLNML---
-----GIY-DGK----RHLIFGEPRKLITQDLSLC------RNQQD-ES-PGV------F
----GQGE----------------------------------------------------
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-----------------MPS-CQKHE-G----------------GLQD----QGE-EPD-
-------------IDEQIFESEEE------------------------------------
-----------------------------------------------------------S
E-EE-----------------------FF-ATY---------------------------
------------------------------------------------------------
---SSSSSSPLI----LSN--PDDF---F---------------------A---------
--------IQT--------------------------------------PSPP---QSPP
QSPHSISS----PT----A--FPWSQSDD----------------S-CSS-QEEEGP---
------------S------TWQDPE------------NAESLLQNALDEKVEELV-----
-------QLLLHKYRMKEPIT-KAEML--SCVIKDYE-----DYFTVIFSKVSRC-----
----LQMVFGID---------VKE-VDPMG---------HSYV-----------------
-------L----------------------------------DTALGL-TYD----GMLD
---DD-QSMPKTGLL-------IIILGVIFTEGNC------VPEE---ELWEALSVM---
-----GVH-VGS----EHHIYGEPWKLITEDWVLE------GYLEYLQV-PHSDPPHYVF
----LWGPRAYAETS--KMRVLEYLAKFNGGDAT----S-FPLCYEE---ALRDEEERAQ
GRFATSRGNSA-------------------------------------------------
------------------------------------------------------------
-----------------------MA--------R----------------TSS-----S-
------------------------------------------------------------
---------TTS---------------------RSFP-----------------------
------------------------------------------------------------
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--------------------------------------MPLEQ-----------------
-----------------RSQ-HCKPE-E----------------GLEA----QGE-ALG-
-------------LVGAQAPAIEE------------------------------------
-----------------------------------------------------------Q
E-T---------------------------------------------------------
------------------------------------------------------------
----ASSSSTLV----EVT--LGE------------------------------------
---------VP--------------------------------------AAES---PSPP
HSPQGAST---LPTTIN-Y--TLWSHSDE----------------GSSN--EEQEGP---
------------S------TFPDL---------------ETSFQVALSRKMAELV-----
-------HFLLLKYRAREPFT-KAEML--GSVIRNFQ-----DFFPVIFSKASEY-----
----LQLVFGIE---------VVE-VVRIG---------HLYT-----------------
-------L----------------------------------VTCLGL-SYD----GLLG
---DN-QIVPKTGLL-------IIVLAIIAKEGDC------APEE---KIWEELSVL---
-----EAS-DGR----EDSVFAHPRKLLTQDLVQE------NYLEYRQV-PGSDPACYEF
----LWGPRALVETS--YVKVLHHLLKISGGPHI----S-YPPLHEW---AFREGEE---
------------------------------------------------------------
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------------------------------------------------------------
--------------------------------------MPRGQK---SKLRAREKR-RQA
-RS-----EKEDL-----------------------------------------------
-GD-------------AQATAAA-------------------------------------
------------------------------------------------------------
DASH-------------------------SPTCP-----V---------------CEGGS
QNLS-G------------------------SEKPS-------T-------SKMSQE---T
P--STSRATE-A------------------------------------------------
------------------------------------------------------------
-----------------V--------ANEGA---------------NS-Q-DE-T-----
------------------------------S-S--SRASEKFRKDPLNKNVVLLV-----
-------QFLLQKYQKKEPIT-KADMM--KFIIKKYK-----CQFNEILRRASEH-----
----MELAFGVD---------LKE-VDPVR---------HCYA-----------------
-------L----------------------------------VNKLDI-STD----GSVG
----EEENMPKTGLL-------MIVLGVIFMKGNC------APEE---DIWEVLNMM---
-----GVY-ADK----KHFIYGDPRKVIAEDLVQL------RYLKSQQV-PDSDPPRYEF
----MWGPRSYAETS--KMKVLEFLAKVHNTVPS----A-FPSWYEE---ALQDEEERAQ
AR-TAARARSARL-----------------------------------------------
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------------------------------------------------------------
--------------------------------------MPRGQK---SKLRAREKR-RQA
-RG-----DAHSV-----------------------------------------------
-QG-------------AQATAAEE------------------------------------
------------------------------------------------------------
-ESP-------------------------SSSSP-----P---------------FGESP
PSSP-A-------------------------AGV----------------SQGPQS---I
P--PTTTAA-AG------------------------------------------------
------------------------------------------------------------
-----------------AS----GTGAAGGA---------------EG-Q-DE-GGP---
-----------------------------GS-SEAPGPTERPQKDPLSRQAGMLM-----
-------QFLLHKYRMKESLT-KTEMM--KSIGKKYK-----QHFPEILRRAAER-----
----VELVFGLD---------LKE-VDPSS---------QTYA-----------------
-------L----------------------------------VSKLHI-TNE---NAM-N
----DGGEFPKNGLL-------MPLLGVIFMKGNR------ATEE---EIWEFLNIL---
-----GVY-DGR----RHLIYGEPRKLITKDLVQE------KYLEYRQV-PNSDPPRYEF
----LWGPRAHAETS--KMKVLEFVAKVNDTVPS----A-FPLQYEE---ALRDEERRAR
AR-AAA---RA-AR----------------------------------------------
----------------------------------------------------------AS
--------------------AHS--R-----------------------ATSS-TSSHP-
------------------------------------------------------------
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------------------------------------------

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------------------------------------------------------------
--------------------------------------MEPTE-----------------
-----------------NNQ-NFNLW-D----------------IPRA----QTE-ERG-
-------------PGSTQDP----------------------------------------
------------------------------------------------------------
--------------------------------------IAEA------------------
------------------------------------------------------------
---EEVEAIATA----PGD--V--------------------------------------
----------P--------------------------------------AGGT---PSSP
QSAQGDPS---PPTAMG-S--IS-----------------------------GASFE---
------------N------PLSEVS------------GAESPSQDGLNEKIIDLV-----
-------RFLLVKFRRMELTN-KEEMI--VKTMGDYE-----EHYSVIFSKAAEC-----
----MKLIFGVD---------MLE-VDPFV---------HSYF-----------------
-------L----------------------------------HPALGI-TYD----GM--
LH-GV-IGVPKTGLV-------ILVLCVIFIENNC------VREE---VFWHAMNIL---
-----GMQ-AGI----DHFIFGEPRSLITEDFVEE------GYVEYRQV-PNSNPPCFEF
----LWGARAYAETT--KMKILEFYASIVRQDPR----S-YPEKYAE---ALREEQERA-
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------QQEGKEQ-----------------
-----------------KEE-KEE----------------------------QE--EE--
------------------------------------------------------------
-----------------------------------------------EEEQEE-------
-EKQQEVET------EQ---------------------QEE-------------------
---------------------------------------------------------EEM
EQEEEK--VH--------E--EEKQQ-EE-------------------------------
-----EEEQ------------------------------------------------EPP
ESPGSFFS----------S--TSCSTSDE----------------DSSSQ-EEEGTG---
-------------------FHQASE------------DTKSLPRDLLNEKVANLV-----
-------HLMILKYQQKEPIT-KAEML--KVAIKRDN-----KQFLVTFEKACKC-----
----LEVISGID---------VKE-MDPKT---------HCYV-----------------
-------L----------------------------------FNSLGL-THD----KI--
VS-DD-QNMPTNGLL-------IIILGVIFIEGNC------VPEE---NIWNFLNMI---
-----GIK-AGR----KHFIYGEPRKLITRNWVQE------NSLEYRMV-SNSDPSRCEF
----RWGPRSYAETS--KLKVLEFLAKIKGIDLI----S-FSDCYEE---ALRDEEERAG
ARNNSMDSNTA-------------------------------------------------
------------------------------------------------------------
-----------------------MF------IVQ----------------HLL--V----
------------------------------------------------------------
---------------------------------IPDP-----------------------
------------------TEET--------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
-------------------------------------MPPPP-P----------------
-----------------KRR-RFSLE-E----------------GLGP----QGE-TLG-
-------------TVGIQVPLNVE------------------------------------
-----------------------------------------------------------E
D-AS-----------------------SSNCSS---FPSL-P------------------
------------------------------------------------------------
--SFSSSGYPPD----LST--SEEVAAAA---------------------A---------
----------A--------------------------------------ATVT---LNPL
QYPQRACC---SPTAMT-S--ALFLESEE----------------G-SRC-QEEEGL---
------------S------SSQALP------------EAESSLENEIEGKVSDLV-----
-------HFLLHKYRVKEPTT-KEEML--SSVIQNYQ-----DFFPEILSKASEC-----
----LLLVFGID---------VKE-VDPIG---------QSYH-----------------
-------L----------------------------------ATTLGL-AYD----GMPS
---DD-NCMPKTGLL-------VIVMGVILMQGNR------ATEG---EVWEVLNMM---
-----EVY-AGI----EHVIYGEPGKLLTEEWVRE------NYLEYRQV-PGSDPACYEF
----LWGPRAHAETS--KMKVLEYLAKIYGSEPT----A-FPLWYEE---ALREEEERAQ
ATMAIADDSTA-------------------------------------------------
------------------------------------------------------------
-----------------------MA--------A----------------PSS-----S-
------------------------------------------------------------
---------ATG---------------------SFSC-----------------------
------------------PE----------------------------------------
------------------------------------------------------------
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--------------------------------------MPCS-S----------------
-----------------KHL-HLTFE-P----------------DIQA----QSE-IQD-
-------------LEVSHVLIAEV------------------------------------
-----------------------------------------------------------K
E-ET-----------------------SSMSFCSFNF--SYPST----------------
-----------------------------------------------------------A
---SSLCSSPVI----PVS--LEEEKEE--------------------------------
-----K-PAAT--------------------------------------LSPL-------
QSPQSS-C---SLSTSWST-------SEG----------------V-SDS-SGEEDT---
------------S------SLKTSI------------DIASLPRDPLNEKVADLV-----
-------HFMILKHQLKEPIT-KVEVL--KVVIKRYK-----KQFPVIFKKASKF-----
----LEVISGID---------AKE-VDPTT---------HFYV-----------------
-------L----------------------------------VNSLEL-THE----EMLS
---NN-QSMPKNGLL-------IIILGVIFMEDNC------ALEE---DIWYFLNVM---
-----GVY-AGR----EHFLYGEPRKLITRDWVQE------NYLEYRQT-PNRDPPCYEF
----LWGPRAHADTS--KMKVLEFLAKVKGTNST----S-VSCWYEG---ALRDEEVRAQ
TRIGSMDNTTA-------------------------------------------------
------------------------------------------------------------
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--------------------------------------MPRGQK---SKLRAREKR-RQA
-RS-----ETQGP-----------------------------------------------
-GS-------------AQATAAEV------------------------------------
-----------------------------------------------------------E
-ES---------------------------CSSP-----V---------------SEGTP
SSPP-A-------------------------AGT----------------PQEPQG---A
P--AT-SSPAAG------------------------------------------------
------------------------------------------------------------
-----------------VS----RPRSHVGA---------------KS-Q-VV-ESE---
-----------------------------NS-SQASASTESSRKALLTRKAEMLV-----
-------QFLLYKYKMKEPIK-QAHML--KVVNKRYR-----EDFPEILKRASER-----
----IELIFGLE---------LKE-VKPNS---------QSYT-----------------
-------L----------------------------------VSKLDL-SND---GSL-S
----SGWGFPKNGLL-------MPLLGVIFLNGNR------TSEE---KIWEFLNML---
-----GVY-DGM----NHFIFGEPRKLITQDLVQE------KYLEYRQM-PDSDPPCYEF
----LWGPRAHAETS--KMEVLEFLAKVNDTVPS----A-FLSHYEE---ALRDEEERAQ
AR-AAARAATP-AT----------------------------------------------
----------------------------------------------------------AS
--------------------ARS--R-----------------------ATSS-RYSD--
P-----------------------------------------------------------
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--------------------------------------MPLEQ-----------------
-----------------RSQ-HCKPE-E----------------GLEA----RGE-ALG-
-------------LVGAQAPATEE------------------------------------
-----------------------------------------------------------Q
Q-T---------------------------------------------------------
------------------------------------------------------------
----ASSSSTLV----EVT--LGE------------------------------------
---------VP--------------------------------------AADS---PSPP
HSPQGASS---FSTTIN-Y--TLWRQSDE----------------GSSN--QEEEGP---
------------R------MFPDL---------------ESEFQAAISRKMVELV-----
-------HFLLLKYRAREPVT-KAEML--ESVLRNCQ-----DFFPVIFSKASEY-----
----LQLVFGIE---------VVE-VVPIS---------HLYI-----------------
-------L----------------------------------VTCLGL-SYD----GLLG
---DN-QVMP KTGLL-------IIVLAIIAIEGDC------APEE---KIWEELSML---
-----EVF-EGR----EDSVFAHPRKLLMQDLVQE------NYLEYRQV-PGSDPACYEF
----LWGPRALIETS--YVKVLHHTLKIGGEPHI----S-YPPLHER---ALREGEE---
------------------------------------------------------------
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--------------------------------------------------MLQKPR---G
R--------------------------------------------------GRPST----
-------QAD----------------------------PERDWGGA--------------
----------GEE----------GPSTSRAA---------------GGSS-Q--------
------------------GSR---------A-SLSAPTVGPRTQKQLELKVAELV-----
-------QFLLIKDQKKIPIK-RTDIL--KHVVGDYR-----DVYPNLLKLAAER-----
----LQYVFGYK---------LVE-LEPKS---------HSYI-----------------
-------L----------------------------------INMLEPVEAD----AEMR
----GDQGTPISGLL-------MIVLGLIFMKGNT------ITET---EVWDFLRRL---
-----GVY-PTK----KHLIFGDPKKLITEDFVRQ------RYLEYRRI-PHTDPVDYEL
----QWGPRTNLETS--KMKVLKFVAKVHNQDPK----D-WPTQYCE---ALADEENRAR
PATA-SAPATSS------------------------------------------------
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-----------------------------------------------------MSEQSKD
LSD---------------------------------------------------------
------------------------------------------------------------
--------PNF----------------------------A---------------CEA-P
NSEV--------------------------HDS-----------------PGVPVG---I
P--AYDSPAATP---------AAQPQSPPLGP------------T---------------
----AAPQAE--------------------------------------------------
------PEP--------------QDPSDEGD---------PKAQ-QQA-A-EQ--GR---
----------------------AHQSP----SAAQPG-PAPPAPAQLVQKAHELM-----
-------WYVLVKDQKRMIIW-FPDMV--RDVIGSYK-----KWCRSILRRTSLI-----
----LARVFGLH---------LRL-TSLHT---------MEFA-----------------
-------L----------------------------------VKALDPEELD-----RMA
----LNNRMPMTGLL-------LMILSLIYVKGRG------ARES---AVWNVLRIL---
-----GLR-PWK----KHSTFGDVRKLITEDFVQQ------NYLKYQRV-PFVEPPEYEF
----FWGSRARREIT--KMQIMEFLARVFKKDPQ----A-WPSRYRE---ALEEARALRE
ANPSV----------------------------------QYPRNSVSED-----------
------------------------------------------------------------
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--------------------------------GD----------------MPQKPR---I
R--------------------------------------------------ARPSA----
-------P----------------------------------------------------
---SPRGGGVAEE----------APSTSRGP---------------GGSQ-E--------
------------------ARCPSSQGG--RR-AEASPAVGPRSQKQLELKVAELV-----
-------QFLLIKDQKKIPIK-RTDIL--KHVVGDYK-----DIFPDLLKLAAQR-----
----LEYVFGYK---------LVE-LEPKS---------NSYI-----------------
-------L----------------------------------INTLEPVEED----AEVR
----GDQGTPTTGLL-------MIVLGLIFMKGNT------IKET---EVWDFLRRL---
-----GVS-PTK----KHLIFGDPKKLITEDFVRQ------RYLEYRRI-PHTDPVDYEF
----QWGPRTNLETS--KMKVLKFVAKVHNQDPK----D-WPAQYCE---ALADEEARAR
PETG-GPAPS--S-----------------------------------------------
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--------------------------------------MPRGQK---SKLRAREKR-RKA
-RE-----ETQDL-----------------------------------------------
-KV-------------AHATAAEK------------------------------------
-----------------------------------------------------------E
-ECP-------------------------SS-SP-----V---------------LGDTP
TSSP-A-------------------------AGI----------------PQKPQG---A
P--PTTTAAAA-------------------------------------------------
------------------------------------------------------------
-----------------VS----CTKSDEGA---------------KC-Q-GE-ENA---
-----------------------------SF-SQATTSTESSVKDPVAWEAGMLM-----
-------HFILRKYKMREPIM-KADML--KVVDEKYK-----DRFIEILNGASRR-----
----LELVFGLD---------LKE-DNPSG---------HTYT-----------------
-------L----------------------------------VSKLNL-TND---GNL-S
----NDWDFPRNGLL-------MPLLGVIFLKGNS------ATEE---EIWKFMNVL---
-----GAY-DGE----EHLIYGEPRKFITQDLVQE------KYLKYEQV-PNSDPPRYQF
----LWGPRAYAETT--KMKVLEFLAKMNGATPR----D-FPSHYEE---ALRDEEERAQ
VR-STVRARRR-TTAT--------------------------------------------
--------------------------T-------------------------------FR
--------------------ARS--R-----------------------APFG-RSSHPM
------------------------------------------------------------
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--------------------------------------MSHK-Q----------------
-----------------Q------YE-K----------------EL-----------EG-
-------------QLWEEFPGATD------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------VGT--PEEV---P---------------------AAG-------
------------------------------------------------------------
-VSQEACS---SSASIQ-A--TPPRKANE----------------G-SGG-EAEGDQ---
------------S------PSKAYL------------FSKFLLNSELRKKITDVV-----
-------KFLSVKYMANEPVT-KEEIL--KNVVQEYK-----NYYELVFKHACEC-----
----MEVVFGIE---------VKE-VDAFN---------HSYK-----------------
-------L----------------------------------IKILDL-TYD----GQLS
---D-DEGIPKTGLL-------VLILGVIYMEGNR------APEK---KIWEVLNIV---
-----GVY-PDQ----HDFICGNPRKFITEDLVLE------KYLEYQLV-PGSDPLCYEF
----LWGPRAHAETS--KMKVLQFFCKVSGSNPT----S-FAALYME---ALKDEEERAQ
AVLATDANPSA-------------------------------------------------
------------------------------------------------------------
-----------------------PD--------N----------------SGS----GD-
------------------------------------------------------------
---------KPS---------------------SFSG-----------------------
------------------PE----------------------------------------
------------------------------------------------------------
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--------------------------------------MPRGKK---SKLRARGKR-RET
-HD-----QLQGL-----------------------------------------------
-TG-------------PQATAEKQ------------------------------------
-----------------------------------------------------------E
-ESR-----------------------SSSSSSA-----V---------------CRGAR
RRSS----------------------------GSS-------V-------PQESQG---A
S--PTGYPDAGASCSKYDVAA----MGQDEKS------------PSTSRDASISQESQ-G
ASPIGPPDAGISC---------SKS--------DEAAKGQNEKSPSTSRDASV-----PQ
ESQGASPTG---SPDADVS----GSKSDVAA---------------KGQ---DEESL---
-----------------------------SS-SKRAALFTTTDGDPLKRKANKMV-----
-------QFLQEKFEKKEPIL-KADML--KRLRRQYK-----PCFPEILKRTSER-----
----LTVFFGVE---------LKE-TDSSG---------ESYT-----------------
-------L----------------------------------VSKLGL-SSE----GILS
----GDNALPKSGLL-------MSILGLIFMRGNR------ATEE---EAWKFLGLL---
-----GIY-DGI----LHSIYGDARKIITEDLVQD------KYVVYRQV-YNSDPPCYEF
----LWGPRAHAETT--KMRVLRVLTEINNTSPG----L-YPHLYED---ALTDEVERAL
RLRA--------------------------------------------------------
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---------------------------------------MSDT-----------------
---------------SE-SGA----------------------------GPACFQAKASE
KDSG-SMIQTLL-------IVTK--NLEVSETPKAS------------------KA----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------QEISETAKVS-------KALGVL---------------KTM-----------
-------------KV---------------------------SKAPKAQAAS-AIQSSPA
-KQLTDTQVLTA----EN--KSPAGDS--KTQNTDLR-------AVAMPAT---------
----ETKK-----VSC--------------------------------------------
------------------------------------------------------------
--------------------------------------------------------VA--
-------------------------------DMKV-------------------------
----N-T--KASEIEA--------TASQAQADE-----------PEHEGTAVQAQENQDT
RPKVK--------------------A---------------------------------K
KARKVKHLEGEEDGS---------------SDQSQTSGTTGGRRVSKALMASMAKRASRG
PIAFWARRAS----RTRLA----A------------------------------------
------------------------------------WARRALL----SLRSPKARRGKAR
RRA---------------------------------------------------------
-AKLQS-SQEPETPP-PRDVALL---QGRANDLVK------YLLAKD-KTKIPI--RR--
------------------------------------------------------------
----SDM---LKDIIKEYTDVYPEIIERAGYSLEKVFGIQLKEIDKNDHLYI-LLSTLEP
TDAGIL-GTTKDS-PKLG---LLM----------VLLSI----------IF--------M
-NGNR----S-S--EAVIWEVLRKLGLR--PGIHHSLFGDVKKLITDEFVKQK-------
---------YLDYARVPNSNP---P--EYEFFWGLRSYYETSKMKVLKFACKVQKK---D
------PKEWAAQYREAMEADLKAAAEAAA--EAKAR----AEIRARMGIGLGSE-----
----NAAGP--CNWD-------------EADIGPWA-KARIQAGAEDKAKVQESG--SAS
TSA--SP------S----TGTSASASA--SGGFSASTSLTATLTFGLFAGLGGAGASTSG
SSGACG-FSYK-------------------------------------------------
------------------------------------------------------------
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------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------MPRGQK---SKLRAREKR-QRT
-RA-----QTQDL-----------------------------------------------
-KV-------------GQATAAEK------------------------------------
-----------------------------------------------------------E
-ESP-------------------------SSSSS-----V---------------LGDTP
SSSL-A-------------------------LGI----------------PQKPQR---E
P--PTTPAAAAMSGTG--------------------------------------------
------------------------------------------------------------
--------------------------PDEGE---------------ES-Q-DEENA----
-----------------------------SS-SQASASTERSLKDPLTRKTKMLV-----
-------QFLLYKYKMKEPTT-KAEML--KIISKKYK-----EHFPEIFRKVSQR-----
----TELVFGLA---------LKE-VNPTT---------HSYI-----------------
-------L----------------------------------VSMLGP-SND----ENES
----SAWSLPRNGLL-------MPLLSVIFLNGNC------AGEE---EIWEFLNML---
-----GIY-DGK----RHLIFGEPRKLITQDLSLC------RNQQD-ES-PGV------F
----GQGE----------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
-----------------KPVR-KAHML--KFIAKKYQ-----NRFPEILRRASFS-----
----MEMLFGVD---------LKE-VDRTK---------HTYT-----------------
-------F----------------------------------VSKMAL-PND----GTMS
----RGSGLPKTGLL-------MYILAVILMKGNC------ATEE---NIWEFLNKM---
-----RVY-AGK----RHFIFGEPKKLITQDWVKL------KYLEYRQV-ANSDPARYEF
----LWGPRAHAETS--KMKVLEFLAKVNHTVPS----A-FQSWYEE---ALKDEEERAQ
ASGC-SSVLSS----SSHT-----------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------MSEQSKD
LSD---------------------------------------------------------
------------------------------------------------------------
--------PNF----------------------------A---------------PDA-A
NSEV--------------------------QES-----------------SEIPVG---V
P--PPTSPAAI----------VAEAPEAPEGP------------M---------------
----AARQAS--------------------------------------------------
------PPP--------------PERLEDID---------PKIL-EQA-I-EE--GR---
----------------------AHNPD--SPVRQ--L-PTPPAPAQVVQKAHELM-----
-------WYVLVKDQKRMVLW-FPDMV--KDVMGSYK-----KWCRSILRRTSLI-----
----LARVFGLH---------LRL-TNIHT---------MEFA-----------------
-------L----------------------------------VKALSPAELD-----RVA
----LNNRMPMTGLL-------LMILSLIYVKGRG------AREG---AVWNVLHIL---
-----GLR-PWK----KHSTFGDVRKIITEEFVQQ------NYLKYQLV-PHSDPPEYEF
----FWGSRANREIT--KMQIMEFLARVFKKDPQ----A-WPSRYRE---ALEQARALRE
ANLAA----------------------------------HCPRSSVSGD-----------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------MAE-
----------------------------------------------------------GS
YR-----T-E-------SETYNVEDMDEGSDEVG--EEEMVEGNDYE----EFGAFGGYG
TLTSFDIRI--LRAFGSLG-----------------------------PGLRILSNEPWE
LENP-MLARTLM-------EAFQ--LDPETLANEAAARAA-------------NVARAAA
---S----------NRA-ARAA--------------------AAAARATYNQV---VANH
-------------------------------------------------PVTT-------
------DQASGEDPRPMTYGAQ--GQ--------------------AATPETIRAAPHIS
------QMLVNSEMAAPGAPAT-STQPHTAS---------------QAQ-----------
-------------EAA----------------NEGPSSACAFSQAPCASEMD-ATRPKTA
FLGQ----------------------------NDIFD-------FTQPAGV---------
----SGMAFPRPKRPAPAQEA--ATEGPSA---------ASSGVPQAAPAREGAATRPKT
T-----------------------------K-----------------------------
------------------------------------------------------------
--------------------------------------------------------SGKA
LAKTRWVEPQNVVAAA--------AAKAKMATTS---------IPEPEGAAA---TAQRS
AE-----------------------P---------------------------------W
VRMGGKRTKKSKHLDDEY--------ESSE-EEREPPAVPPTWRAPQPPLT---------
---------V----R---------------------------------------------
----------------------------------------AQVA----------------
-----------------PRPS-----------------------------M----A----
-LRSQVPSRHVLCLP-PRNVTLL---QERANKLVK------YLMIKD-YKKIPI--KR--
------------------------------------------------------------
----SDM---MKDVIREYDEHFPEIIERATYTLEKKFGIHLKEIDKEEHLYI-LVCTRDS
SAR-LL-GKTKDT-PRLS---LLL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPFLGDLKKLITEDFVKQK-------
---------YLEYKKVPNSSP---P--EYEFFWGLRARHETSKMRVLRFIAQNQNR---D
------PREWKAHFLEAVDDAFKTMDVDMA--EEHAR----AQMRAQMNIGDEAL-----
------IGR--WSWDDIQVELLT-WDEDGDFGDAWA-RIPF----AFWARYHQYILNSNR
ANRRA------TWRAGVSSGTNGGASTSILDGPSTS-ST---IRTRNAARTS--------
----ANFFSWIQQR----------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
---------------------------------------MAQKMDCGAGLLGFQA-----
--------------------------------------------------------EASM
EDST-LLMQTLM-------EAIQ--IS-EAPPTNQA--PA--------------------
------------------------------------------AAFGQNSCPQSSQPPTT-
---------------------------------------------------AD-------
------YQVSAAAARPRA------------------------------------------
-----------------------------AF---------------RAQ-----------
-------------NAT----------------TKGPNAAYDFSQALHAKET----SPKPA
F-------------------VTQTATP--NSPNTAYD-------FSQAAT----------
----KELTANKSEITFKAQNAT-TKVGPNA---------T-YNFSQSLNASEMSNTQPKT
------------------------------------------------------------
----------------------------------------------AFKAWNHVTKAPTA
-------------------------------DTQT-----------QNV-----------
----NQT---KMATSK--------ADIEAN--PV---------ISVSDGAAAQTSADGSQ
AQNLE--------------------S---------------------------------R
TIIRGKRTRKINNLNV---------EENSSGDQRRAPLPAGTWRSAPIPVTT-QNPPCAP
PNVLWQTPLA----WQNPS----GWQNQPVRQIP----P-ARQSPPARQTPLAWQNPVAW
QNPVIWQSPVIWQSPVIWPNPI-VWPGPVVWPNPLAWQNPPGWQAPPGWQNPPGWQGPPD
WQG---HPDWPLPHNW-PQPP-DWPLP-TDWQLPHEWIPTNWPVPPDRQNLRPSSNLRP-
-SPNPRAPQNMRASQ-PRDVALL---QERANKLVK------YLMLKD-YTKVPI--KR--
------------------------------------------------------------
----SEM---LRDIIREYTDVYPEIIERACFVLEKKFGIQLKEIDKEEHLYI-LISTPE-
SLAGIL-GTTKDT-PKLG---LLL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPLLGDLRKLLTYEFVKQK-------
---------YLDYRRVPNSNP---P--EYEFLWGLRSYHETSKMKVLRFIAEVQKR---D
------PRDWTAQFMEAADEALDALDAAAA--EAEAR----AEARTRMGIGDEAV-----
------SGP--WSWDDIEFELLT-WDEEGDFGDPWS-RIPF----TFWARYHQNSRSRFP
QTFTG---------------------P--IIGSGGTASA------NFAANFGAIGF----
--------FWVE------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------MPR---------------------------
----------------------GQKSK-------------------------------LN
ARR--------------------RRR-RARNDAQA---SEGAQKAVEATEESS-PESCG-
--------------------------------------ASEMPE-K------------QS
---------VSSI---T-------------TGVLSFSISDESS---------IDDL----
DDEENLLRN--YHSI-NLHQDIL---ARKVFVLSQ------ILLDNY-KMRKLT--TM--
------------------------------------------------------------
----EDM---MQVIDKEEINAFPEILKKAAERLSDFFAVEVREVESSRQVYD-LISKLKL
PNNGRV-RPGQGL-PKTA---FVM----------TVLGM----------IF--------M
-NGNC----V-R--EEDIWRMLRSMEVY--PGKKHRIFGEPRKLMTQYLVKLE-------
---------YLEYRQVAGSDP---P--HYEFLWGPKAYAETNKITVLKFVAKIYKI---P
------PRYFSDLYEQALKEDKEKDQGNHE-I----------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------

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--------------------------------------MPRGQK---SKLRAREKR-RDT
-HG-----QPQSL-----------------------------------------------
-PG-------------PQTTVEKQ------------------------------------
-----------------------------------------------------------K
-EPP-----------------------TSTIS-S-----D---------------YRGAH
PKSS----------------------------DAS-------V-------PQESQG---A
S--PTGSPDAGVSCSKSDVAA----KGQDDKS------------AGTSPDASVPQESQ-G
TSPTESPDADASC---------SKS--------DVAAKGQDDKSAGTSPDASV-----PQ
ESQGASPTE---SPDAGAS----CSKSDVAA---------------KGE---DEESA---
-----------------------------HA-SQRAMYFKSLGRDPINKKSWELV-----
-------QFLQEKFEKNESIL-KADML--KLVSKRYK-----EYFPEILKQTSEH-----
----LVVTFGVE---------LKE-MDSSG---------ESYT-----------------
-------L----------------------------------VSKLGL-SSE----GSLS
----GYNGLAKSGIL-------MSALGLIFMKGNR------ATEE---EVWDFLTFL---
-----GIS-SRM----THPLYGDPEKVLTEDLVQA------KYLEYRQV-CNSDPPRYEF
----LWGPRAHFETS--KMRVLDVFAKINNTVPG----F-YPHLYEE---ALVDEVQKAL
RVNF--------------------------------------------------------
------------------------------------------------------------
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------------------------------------------

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------MK-----------------------G----------RRLTGRN-----------
------GDPLWRRKEAGPL---------------------------P----AREG-----
-----------------------------------------------DRLRHKE-RLGES
----------RRLLDSRRR-----------------------------------------
-----------------------GPFPSDSAVTRP-PRKMDRRNDYGYRVPPFQ--G---
--------PLPPP--GSLGLP----------------------------FPPDIQTETTE
EDSV-LLMHTLL-------AATK--DSLAMDPPVVNRPKK-------------SKTKKAP
IKAI----------TKA-APA--APPVPTASEIATNKPKITLQALNLPVITQISQASPT-
T------------------------------------------------EVTN-------
------TQVSSVTVQPKKANKMKRVTAKAAQG-SQSPTGREGGATQLKSPLQVLNLPVIS
QNIHA---PIANESASSQTL-ITSIKPKKAS---------------KAK-----------
-------------KAA----------------NKAIASATEVSLAPTATHTA-TTQGQIT
-NETASIHTTAACIRTKKASKARKTIA--KVINTDTE-------HIEAANV---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------TETAT
RQIEA--------------------S---------------------------------V
VAIRPKKSKGKKAASRGP---------N------------SVSEISEALLATQMVTNQAL
AATLRVKRGS----RAWKA----STKARATESQT----PNADQGTQAKMASAQ-TNVSAL
ETQ------------VA------------AAVQALADDYLAQL----SLEPTTRTRGKRN
RK-----------------------------------------------SKHLNGDERS-
GNNYRRIPWGRRPAP-PRDVAIL---QERANKLVK------YLLVKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LRDVIQEYDEYFPEIIERASYALEKMFRVNLKEIDKQSSLYI-LISTRES
SAG-IL-GTTKDT-PKLG---LLM----------VILSV----------IF--------M
-NGNK----A-S--EAVIWEVLRKLGLH--PGVRHSLFGEVRKLITDEFVKQK-------
---------YLEYKRVPNSRP---P--EYEFFWGLRSYHETSKMKVLKFACKVQKK---D
------PKDWAVQYREAVEMEVQAAAVAVA--EAEAR----AEARAQMGIGEEAV-----
------AGP--WNWDDMDIDCLT-REELGDDAQAWS-RFSF----EIEARAQENADASTN
VNFSRGAGTRAGFSDGASISFNGAPSS--S----G-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------GPGITFGGAPSSSASFGNTASISFGGTLSTSS----------------
--------------------SFS------------------S----------------AA
RISFGGAPSTSTSFSSEASISFGGTPCTSASFSGGVSSSFSGPLN--S-ATFSGAASSGF
GG------------------TL-STTAGFSGVLSTSTSFGSAPTTNTVFSSALSTSTGFG
GTLSTSVCFGGSPSSSGSFGGTLSTSICFGGSPCTSTGFGG----TLSTSVSFGGSSSTS
ANCGGTLSTSICFDGSPSTG-AGFGGALNTSASFGGALNTS-------------------
-------------------------------------------------AGFGGAMSTST
NFGGTLSTSVCFGGSPGTSVSFGGALNTSAGFGGAVSTSTDFGG----------------
------------------------------------------------------------
-----TLSTSVC------------------------------------------------
----------------------FGGSPSTSAGFGGALNTNASFGCAISTSAGFSGAVGTS
AGFSGVPNTNPGFGGAFNTNAGFGGALSTTTEFGGTPSNSIGFGAAPSTSVSFGGAHSTS
LCFGGAPSTSLCFGSASNTNLCFGGPPSTSACFSGATSPSFGDGPSTSTGFSFGNGLSTS
AGFGGGLNTSAGFGGGLGTSAGFSGG------------------------------LSTS
SGFDGGLGTSAGFSGGPGTSTGFGGGLGTSAGFSGGLGTGASFGGGLVTSDGFGGGLGTN
ASFSSTLGTGAGFSGGLSTSDGFGSRPNASFDRGLSTIIGFGSGSNTSTGFTGEPSTSTG
FNSGPSSIVGFSDGPSTGVGFCSGPSI-SGFSGGPSTGAGFG------------------
------------------------------------------------------------
-------GGPNTGAGFGGG-LSTSAGFSSGATSLGACGFSYG

------------------------------------------------------------
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------------------------------------------------------------
--------------------------------------MPRGHK---SKLRAQEKR-RQN
-RA-----EKQGD-----------------------------------------------
-KS-------------AQAP----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--ST-G-------------------------AGT----------------LQAPQG---A
P--ATTSAAA--------------------------------------------------
------------------------------------------------------------
----------------GAS----GERSAVKA---------------EG-Q-VQQSKK---
------------------------------S-PQASTSAESSGKRLLSKKATMLV-----
-------EYLLYQYKRNQPIK-KRDML--KIIHKWFR-----KDFPEILKKASER-----
----MDLFFGLE---------LKE-VEPNG---------NTYT-----------------
-------L----------------------------------VIIEDE---------SLS
----SGFSFPNKGIL-------MPVLGFILLNGNR------VSEA---DTWVFLNTL---
-----GIF-DGK----SHLIFGEPRKLITQELVQG------KYLVYQPV-PNSHPPRYEF
----LWGPRAHAETS--KMKVLEFWAELNDTVPT----T-FGLHYEE---ALKDEEERAR
AEAA-PTA----------------------------------------------------
-----------------------------------------------------------A
--------------------------------------------------------T---
------------------------------------------------------------
------------S-----------------------------------------------
------------------LEATS---S-CYPQPE--------------------------
------------------------------------------------------------
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------------------------------MPR---------------------------
----------------------SQRSN-------------------------------LC
--------------------VREKRQ-QKQA-----------------KEEFP-SSSTP-
--------------------P-FGCTTQR-KPGAKSCSTLQGPQ-R-------------H
---------LFTP-----------------TTPGASRTRSHAG-------------IKNK
DK--KSSSEDQPSTK-QSHRDPL---TKKVGTLVQ------FLLETY-KTKKPV--MK--
------------------------------------------------------------
----ENM---MKIVNKKHKSRFLEILRRASFSLEVVFGIDLKEIDSIKPSYT-LVSKMDL
PNNGRQ-NRGRGL-PKTG---LLM----------ILLGV----------IF--------M
-KGNC----A-S--EEKIWEFQNKIRIF--AGKRHFTFGEPRKLITQDFVKLK-------
---------YLEYHQVPNSDP---P--SYEFLWGPRAHAETSKMK-LEFLAKINDT---V
------PSALPSLYEEALRDEEERARATVP-DRADPTAMAS-------------------
------------------------------------------------------------
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---------------------------------------MSDT-----------------
---------------SE-SGA----------------------------DPARSQGKASE
KDSG-SVMQDLL-------TVTQ--NLEVSETPKAE------------------KA----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------PEVSEAAKAP-------KASGNP---------------KAT-----------
-------------EV---------------------------SKAPEASEAA-ATQASPT
-TQLSETQVLAT----EN--KSPAADT--KTQKSDLQ-------AMTMPTT---------
----PTKK-----VSC--------------------------------------------
------------------------------------------------------------
--------------------------------------------------------GT--
-------------------------------DPKV-------------------------
----N-T--KAPETEA--------PASQAGTDEP---------EP--EGTAVQVQENQDT
RPKVK--------------------A---------------------------------K
NTQKGKHPDGEEDGN---------------SDQSQASEATGGRRVSKALMASMARRASRG
PIAFWARRAS----RTRLA----A------------------------------------
------------------------------------WARRALL----SLRSPRARRGKAR
RRA---------------------------------------------------------
-AKLQS-SQEPEAPP-PRDVALL---QGRANDLVK------YLLAKD-QTKIPI--RR--
------------------------------------------------------------
----SDM---LKDIIKEYTDVYPEIIERAGYSLEKVFGIQLKEIDKNDHLYI-LLSTLEP
TDAGIL-GTTKDS-PKLG---LLM----------VLLSI----------IF--------M
-NGNR----S-S--EAVIWEVLRKLGLR--PGIHHSLFGDVKKLITDEFVKQK-------
---------YLDYARVPNSNP---P--EYEFFWGLRSYYETSKMKVLKFACKVQKK---D
------PKEWAAQYREAMEADLKAAAEAAA--EAKAR----AEIRAQMGIGLGSE-----
----NAAGP--CNWD-------------EADIGPWA-KARIQAGAETKAKAQGSGGANAS
AGAG--ASTGTSVGASGSASAGASAGA--SGGFSNNSSLTASLTFGLFAGLSGAGASTNS
SSGACG-FSYK-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-SIS-P-------------------------PGH----------------MLQKTR---S
R--------------------------------------------------SHPGA----
-------QLG----------------------------GGSGCCP---------------
--------SVSGE----------IPSVAGHP---------------DASL-D--------
------------------TLGARSLS---SQ-AQATSTRELRTQKQLELKVAELV-----
-------QFLLIKDQKKIPIK-RSGIL--KHVIRDYK-----DIFPDLLKLAAER-----
----LHYVFGYK---------LVE-LEPKS---------NAYI-----------------
-------L----------------------------------INALEPVEED----GELR
----GYQGTPTTGLL-------MIILGLIFMNGHS------IPEA---DVWDFLRRL---
-----GVC-PTK----KHSVFGDPKKLITEDFVRQ------RYLESRRI-PHTDPVDCEL
----QWGPRANLETS--KMKVLKFVAKIHNQDPK----D-WPTQYCE---ALADEQRRLR
PEPS-GPVPTS-------------------------------------------------
------------------------------------------------------------
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------------------------------------------

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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------MPRGHK---SKLRAREKR-RKA
-RE-----ETQGL-----------------------------------------------
-KV-------------AEATAAEK------------------------------------
-----------------------------------------------------------E
-ECP-------------------------SS-SP-----V---------------LGDTP
ASSL-A-------------------------AGI----------------PQKPQG---A
S--PTTTAAAA-------------------------------------------------
------------------------------------------------------------
-----------------VS----CTESDEGA---------------KG-Q-GE-ENA---
-----------------------------SS-SQGTTSTEKSVKDPVAWEAGMLM-----
-------HFMLHKYKMREPIM-KADML--KFVDEKYK-----DHFPEILNRASHR-----
----LELVFGLD---------LKE-DNPSG---------HTYT-----------------
-------L----------------------------------VSKLNL-TND---GNL-S
----NDWDFPRNGLL-------MPLLGVIFLNGNS------ATEE---EIWKFMNML---
-----GAY-DGE----EHLIYGEPRKFITQDLVKE------KYLKYKRV-PNSDPPRYQF
----LWGPRAYTETT--KMKVLEFLAKVNGTTPR----D-FPSHYEE---ALRDEEERAR
VR-SSVRARRR-TTAA--------------------------------------------
--------------------------S-------------------------------FR
--------------------GRS--R-----------------------AAFS-NSSQPM
------------------------------------------------------------
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------------------------------------------------------------
--------------------------------------------------MSQKPK---S
R--------------------------------------------------GRPSS----
-------QVE----------------------------REPG------------------
--------GGGEE----------APSTSRGP---------------GGAA-S--------
------------------Q----------RR-AQASPAPGPRSQKQLELKVAELV-----
-------QFLLIKDQRKIPIR-RTDIL--RHVVGDYK-----DVLPELLRRAAER-----
----LEYVFGYR---------LVE-LEPRS---------NTYI-----------------
-------L----------------------------------VNTLEPVEED----AEVR
----GDQGTPTTGLL-------MIVLGLIFMKGNS------IKET---EVWDFLRRL---
-----GVH-PTK----KHLIFGDPKKLITEDFVRQ------RYLDYRRI-PHTDPVDYEL
----QWGPRTNLETS--KMKVLKFVAKIHHQDPK----D-WPAQYCE---ALADEEARAR
PQPA-GPSPATAPA--------PTLSPVS-------------------------------
------------------------------------------------------------
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-----------------------------MTSAGVFNAGSDER-------------ANSR
DEEYPCSSEVSPSTE-SSCSNFI---NIKVGLLEQ------FLLYKF-KMKQRI--LK--
------------------------------------------------------------
----EDM---LKIVNPRYQNQFAEIHRRASEHIEVVFAVDLKEVNPTCHLYD-LVSKLKL
PNNGRI-HVGKVL-PKTG---LLM----------TFLVV----------IF--------L
-KGNC----A-N--KEDTWKFLDMMQIY--DGKKYYIYGEPRKLITQDFVRLT-------
---------YLEYHQVPCSYP---A--HYQFLWGPRAYTETSKMKVLEYLAKVNDI---A
------PGAFSSQYEEALQDEEESPSQRCS-RNW----------------HYCSGQDCLR
AKFSSFSQPY--------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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---------------------------------------MSDT-----------------
---------------SE-SGA----------------------------GLTSFQAEASE
KDSS-SMMQTLL-------TVTQ--NVEVPETPKAS------------------KA----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------PEVSEDVKVS-------KTSGVS---------------KAT-----------
-------------EV---------------------------SKTPEAQEAP-ATQASST
-TQLTDTQVLAA----EN--KSLAADT--KKQNADPQ-------AVTMPAT---------
----ETKK-----VSC--------------------------------------------
------------------------------------------------------------
--------------------------------------------------------VA--
-------------------------------DTKV-------------------------
----N-T--KALETEA--------AASQAPADEP---------EP--ESAAAQSQENQDT
RPKVK--------------------A---------------------------------K
KARKVKHLDGEEDGS---------------SDQSQASGTTGGRRVSKALMASMARRASRG
PIAFWARRAS----RTRLA----A------------------------------------
------------------------------------WARRALL----SLRSPKARRGKAR
RRA---------------------------------------------------------
-AKLQS-SQEPEAPP-PRDVALL---QGRANDLVK------YLLAKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LKDIIKEYTDVYPEIIERAGYSLEKVFGIQLKEIDKNDHLYI-LLSTLEP
TDAGIL-GTTKDS-PKLG---LLM----------VLLSI----------IF--------M
-NGNR----S-S--EAVIWEVLRKLGLR--PGIHHSLFGDVKKLITDEFVKQK-------
---------YLDYARVPNSNP---P--EYEFFWGLRSYYETSKMKVLKFACKVQKK---D
------PKEWAAQYREAMEADLKAAAEAAA--EAKAR----AEIRARMGIGLGSE-----
----NAAGP--CNWD-------------EADIGPWA-KARIQAGAEAKAKAQESG--SAS
TGASTST------NNSA--SA--SAST--SGGFSAGASLTATLTFGLFAGLGGAGASTSG
SSGACG-FSYK-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------

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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------MPRGQN---HKLCICEKR-HQA
-RY-----EPQSQ-----------------------------------------------
-KG-------------VQPAAVME------------------------------------
-----------------------------------------------------------E
-LLS-------------------------TSSL----------------------LEDNS
QSSS-A------------------------TGSNS-------T-------SQGSSE---A
P--STTSTFS-T------------------------------------------------
------------------------------------------------------------
-----------------TS----DTKSDEED---------------TS-Q-DE-EDS---
-----------------------------GS-SDVSSSTENTYSDTLNSMTSLLE-----
-------QFLLHKYKMKQPII-KENML--KIIHPRYH-----NRFAEILKRASEH-----
----IEAVFAVD---------LKE-VDSTI---------HSYD-----------------
-------L----------------------------------ISKLNL-PNN----GRVW
----DGRGLPKTGLL-------MTVLAVIFVKGNC------ASEE---DIWKFLNMM---
-----QVY-AGR----KHFIYGEPRKLITKDFVTM------KYLEYRQV-ANSDPPRYVF
----LWGPRAHAETS--KMKVLEFLAKVNDTVPS----A-FSSQYEE---ALRDEEERAR
VT-VPARPG-T-T-----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------MPW---------------------------
----------------------RHNSK-------------------------------YH
--------------------ACVKRY-QVRRDTQC---PQEAQASAAAAA-----EECP-
-SF---------------PFSGPQGSLPS-SP---AAGET--------------------
-----------TS---S-------------PDAGPSCAGSDEG-------------AQGP
EEESA GASQAAPATQ-STRKDPL---ARKASM LVE------FLLEKD-TKKEPI--MQ--
------------------------------------------------------------
----NAL---LTVINRKYRQHFSEILRRASERMELVFGLELKEVNHSRNIYV-LISKLSL
GGDEGP-NDEKGL-PKSG---LPM----------VLLGF----------IF--------M
-KGNR----A-T--EEEVWEFLSVLGVY--AGRKHPIFGEPRRLITKDLVQKK-------
---------SLKYLQVPNSDP---L--CYEFLWGPRACAETSKMKVLEVLAKIHDM---V
------LSSFQDLYDEALRDQAERAGLRGA-TQDPAMAEASAPSRAKSC------SSSHI
--------K---------------------------------------------------
------------------------------------------------------------
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------------------------------------------

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------------------------------------------------------------
--------------------------------------MSQE-Q----------------
-----------------ESL-NCTSE-Q----------------CLQV----YYE-TQG-
-------------LEFAQVPETAD------------------------------------
-----------------------------------------------------------Y
I-----------------------------------------------------------
------------------------------------------------------------
---SSFSSLSLV----PCT--LEDT---S---------------------APG-------
----------A--------------------------------------PKNL-------
QGHESACH---SSSIFR-A--ISSIQSNE----------------GSSSQ-EEDDGR---
------------S------TAEFPQ------------GIENMSRDPLKERVDLLV-----
-------NFLLLKYQLNEPIT-KADML--KSVIKKYK-----DYFPEILRRTTDC-----
----MELLFGID---------VKE-VDPKS---------HCYL-----------------
-------L----------------------------------VNKLDL-TYD----GRLS
---GD-DGMPKTGLL-------ILILGVIFMKGNC------ATEE---EVWEVMNMM---
-----NIY-SGR----KHFLFGEPRKIITGDFVKE------KYLEYRQV-PNSDPPRYEF
----LWGPRAQAEAN--KMKLLEFLAKIHGTSPR----C-FLSQYEE---ALKDEQERGQ
ARIADKAGTTT-------------------------------------------------
------------------------------------------------------------
-----------------------LA--------T----------------ASS----TA-
------------------------------------------------------------
---------RFT---------------------SFSQ-----------------------
------------------P-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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--------------------------------------MSRY------------------
----------------GKHP-RLSLE---------------EGVNFQN----PTE-TDD-
-----------DDVVFPVLPTAEKDEREGEEEVLKEDE-DGN-----KQETEED------
---NVEKEDEDEE----KEK---------------------------EEEKEESGDEVNE
EEDET----------RE-EEDISSMILSSSNVSLAAFSPPSPSS---------------S
---SSS---------------------------------------S-------I-F---S
SSSSSSSLFSLF----QSN--LVENE----------------------------------
---------GF--------------------------------------AIGM---LGLF
QNAQSFFP---LP--------TLGGNLDE----------------AAGYQ-EES--S---
------------G------VIASPE------------DPDSLLDTVIQEKATDLV-----
-------FLFIYKYRVKEPIT-LTEMH--EVVTKEYE-----NHFPVIFIEASKC-----
----LEMTFGID---------IKE-SDLVS---------SAYV-----------------
-------L----------------------------------VNSLNL-TYE----DTLS
---DS-DRLPRNAFL-------IVILGVIFIEGNC------ASED---RIWEFLKLV---
-----GVY-DGE----EHFICGDPREFLTIHLVQQ------NYLEYREV-PNSQPPCFEF
----LWGPRAYAETT--KMKVLEFLAKMNGCDPS----D-FSIWYEE---ALRDEEERAW
ALNDSANTSPN-------------------------------------------------
------------------------------------------------------------
-----------------------AW------FVE----------------R---------
------------------------------------------------------------
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---------------------------------------MSDT-----------------
---------------SE-SGV----------------------------GSACFQTKASE
KDN-----------------VIQ--NLEVSETPKAL------------------KA----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------PEISETAKVS-------KALGVL---------------KAM-----------
-------------KV---------------------------SKAPEAQEAP-ATPSSST
-TQLTDTQVLTA----ET--KSPAADT--KTQNTDLQ-------AVTMPAT---------
----ETKK-----VSR--------------------------------------------
------------------------------------------------------------
--------------------------------------------------------VA--
-------------------------------DVKV-------------------------
----NTK-----------------------------------------------------
------------------------------------------------------------
----------------------------------------ASETEAA---------ASQP
QADESEHEGR--------------------------------------------------
-----------------------------------------TA----QAQENQDTQLKVK
------------------------------------------------------------
-------AKKPKVLP-PRDVALL---QGRANDLVK------YLLAKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LKDINKKYTNVYPEIIEQAGHSLEKVFGIQLKETEKNDHLYI-LLSTLEP
TDAGIL-GTTKDS-PKLS---PFM----------VLLSI----------IF--------M
-NGNW----S-N--EALIWEVLRKLGLR--PEIHHSLFGDVKKLITDEFLQ---------
--------------------S---P--EYEFFRGLRSYYEISKMKVLKFACKVQKK---D
------PKEWAAQYREAMEANLKAAAEAAV--EAKVR----AEIRAQMGIEHGSE-----
----NAAGP--CNWD-------------EADIGPLG-KAWIQAGAEDKAKAQESG--GAS
ASASTGM------------STSASTSA--SGASSASASLTATLTFGLFMGLGGACVSTSG
NSG--G-FSYK-------------------------------------------------
------------------------------------------------------------
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--------------------------------------MPRGQK---SKLRAREKR-RQA
-RE-----EPEPL-----------------------------------------------
-MD-------------AQATARVG------------------------------------
-----------------------------------------------------------I
-EFS-------------------------SSSSA-----H---------------FGSAI
QSST-A------------------------PKTTS-------N-------PHGPQR---A
T--STTTTAA-A------------------------------------------------
------------------------------------------------------------
-----------------VS----YLRSNEST---------------NN-Q-TE-ERP---
-----------------------------RS-SQALAASEHMTRSPVDEKVFILV-----
-------HYLLYKYQMKELII-KAAML--RDIVQIPR-----RYFSEILRKVSDH-----
----LEMVFGLD---------LKE-VDPDR---------HIYF-----------------
-------L----------------------------------INKLVP-TYD----AKLS
----DDRCVPRTGLL-------MTILGVIFTNGNC------ATEE---QIWQVLNVM---
-----GLY-EGR----RHFIFGEPKKIITQDFVRE------NYLQYQQV-PNSDPPCYQF
----LWGPRAHVETT--KMKVLEFLAKIHDTVPS----A-FPTWYEE---ALKDEEERAQ
AR-LAARARIR-AV----------------------------------------------
----------------------------------------------------------VN
--------------------ARS--Q-----------------------AIFS-RFSHP-
------------------------------------------------------------
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--------------------------------------MSHIQ-----------------
-----------------RHD-PG-FE-D-----------------QL-------------
---------------E--------------------------------------------
---------------------------------------------------EEVP-----
--A---------------------------------------------------------
---------------------------------------------------------AEE
VGTWEK------------------VA----------------------------------
---------AT--------------------------------------ES---------
-SQETASS----SASSQ-A--SASSKASE----------------GSGGK-AEGG-Q---
------------S------TSKACL------------RTKLLLNSKFQKKVIDLV-----
-------KFLSSKYVTNEPVT-EAEIL--KSVGKKHK-----GYYSLIFKHACEC-----
----LEVVCGIE---------VKE-VDALN---------HTYL-----------------
-------L----------------------------------LKVLDL-TYD----GRIS
---NK-EGIPKTGLL-------VLVLGIIFMEGNR------ASEK---KIWEVLNIV---
-----GVY-PDQ----HDFICGNPRKFITEDLVLE------NYLVYQPV-PYSDPPSYEF
----LWGPRAQAETS--KMKVLQFFCKVAGSNPA----S-FTALYKE---ALEDEEERAR
ALLASTAIS---------------------------------------------------
------------------------------------------------------------
-----------------------TA------VDN----------------SGS--G--D-
------------------------------------------------------------
---------KPE---------------------DSHS-----------------------
------------------E-----------------------------------------
------------------------------------------------------------
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---------------------------------------------------MLKPE---S
G--------------------------------------------------GLPIP----
-------RAE----------------------------GEMDGGHDSETQALT-----A-
-SQE-------------------SLEEDLGA---------------VREE-E--------
----------------AAEPSITLKGA--RA-LAAKTLARRGARLRLDRTVAELV-----
-------QFLLVKDRKKSPIT-LSEMV--KYIIRDLK-----DLFPEIIARAAEH-----
----LPYVFGFK---------LKQ-LDRKH---------HTYV-----------------
-------L----------------------------------TNKLKPLEEE--------
-----GGDGPRLGLL-------MMMLGFIYMKGNS------AREA---QVWEMLCRL---
-----EVR-PSK----YHPLFGCPRRLIMEDFVQL------RYLNYRLV-SHTNPPACEF
----SD-PRSDLKTS----EVLGFVSL--HKKNQ----H-WPVQYRE---AL--------
------------------------------------------------------------
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------------------------------------------------------------
--------------------------------------MPRGHK---SKARAREKR-RLV
-QD-----EAQEL-----------------------------------------------
-KD-------------AQAKAGEK------------------------------------
-----------------------------------------------------------G
-ESP-------------------------SCSXH-----D---------------SGDAV
ASTS-T-------------------------AGF----------------PEKSKS---Q
G--EAP------------------------------------------------------
------------------------------------------------------------
----------TTKARKGGA----CRRSRKST---------------RG-P-REESAS---
------------------------------C-SRVPRFSENPQNDLLTRKTGILM-----
-------QYLLCKYKMKKPAY-KGEML--KVINRRFK-----EQLPEILKKASER-----
----IQLVFGLE---------VKE-IKPSG---------GYYT-----------------
-------L----------------------------------VSKLDP-SVG----NSLT
----TSLPFPQNGLL-------MPLLGVIFLNGNR------ASEA---KIWEFLNVL---
-----GIY-DGK----VHIIFGEPRKLITRDLVKE------KYLVYQKE-ANSDPPSFEF
----LWGPRAYAETT--KMKILEFLAKVNETVPQ----A-FPTHYEE---ALRDQEERAQ
AEAL-GSP----------------------------------------------------
-----------------------------------------------------------G
--------------------PGAKD------------------------------EA---
------------------------------------------------------------
------------E-----------------------------------------------
------------------AKVTL---G-DPSCTDQ------VE-SKV-TLVDPD--CK--
------------------------------------------------------------
----DQAE----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
--------------------------------------MPRGQK---SKLRARKKR-QQT
-RS-----VAQGA-----------------------------------------------
-KA-------------AHAVGEEE------------------------------------
-----------------------------------------------------------E
-ES--------------------------PSSSP-----V---------------REGTP
PSSP-R-------------------------SCA----------------AQGGLR---G
R--ASSSPEA-G------------------------------------------------
------------------------------------------------------------
-----------------SS----DASSDVDE---------------G-------------
---------------------------------YRAGSSQVSLRDPLNRKASMLV-----
-------QFIMEKYKKREPIV-QADML--KVVKRKYK-----KHFPEILRRTSER-----
----VELIFGLE---------LEE-VDPIS---------RSYV-----------------
-------L----------------------------------INKLSL-SSE---DEV-S
----GERVLPKTGLV-------MTLLAVIFMKGNR------ATEA---EMWEFLNAR---
-----GIY-AGR----RHSIFGEPRKLITEDLVQE------NYLEYRQV-RFRSPPVYEF
----VWGPRAHAETT--KMKVLEVLAKINDTVPR----C-YPDLYEE---ALRDEQERAE
LQ-AVARASTV-AR----------------------------------------------
----------------------------------------------------------SR
--------------------VGS--R-----------------------AKSR-RSSHT-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------

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------------------------------------------------------------
------------------------------------------------------------
--------------------------------------MPRA-P----------------
-----------------KRQ-RCMPE-E----------------DLQS----QSE-TQG-
-------------LEGAQAPLAVE------------------------------------
-----------------------------------------------------------E
D-AS-----------------------SSTS-TSSSFPSSFPSS----------------
-----------------------------------------------------------S
S-SSSSSCYPLI----PST--PEE--VSA---------------------DDE-------
----------T--------------------------------------PNPP---QSA-
---QIACS---SPSVVA-S--LPLDQSDE----------------G-SSS-QKEESP---
------------S------TLQVLP------------DSESLPRSEIDEKVTDLV-----
-------QFLLFKYQMKEPIT-KAEIL--ESVIRNYE-----DHFPLLFSEASEC-----
----MLLVFGID---------VKE-VDPTG---------HSFV-----------------
-------L----------------------------------VTSLGL-TYD----GMLS
---DV-QSMPKTGIL-------ILILSIVFIEGYC------TPEE---VIWEALNMM---
-----GLY-DGM----EHLIYGEPRKLLTQDWVQE------NYLEYRQV-PGSDPARYEF
----LWGPRAHAEIR--KMSLLKFLAKVNGSDPR----S-FPLWYEE---ALKDEEERAQ
DRIATTDDTTA-------------------------------------------------
------------------------------------------------------------
-----------------------MA--------S----------------ASS----SA-
------------------------------------------------------------
---------TGS---------------------FSYP-----------------------
-------------------E----------------------------------------
------------------------------------------------------------
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---------------------------------------MSDT-----------------
---------------SE-SGA----------------------------GLTRFQAEASE
KDSS-SMMQTLL-------TVTQ--NVEVPETPKAS------------------KA----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------LEVSEDVKVS-------KASGVS---------------KAT-----------
-------------EV---------------------------SKTPEAQEAP-ATQASST
-TQLTDTQVLAA----EN--KSLAADT--KKQNADPQ-------AVTMPAT---------
----ETKK-----VSH--------------------------------------------
------------------------------------------------------------
--------------------------------------------------------VA--
-------------------------------DTKV-------------------------
----N-T--KAQETEA--------APSQAPADEP---------EP--ESAAAQSQENQDT
RPKVK--------------------A---------------------------------K
KARKVKHLDGEEDGS---------------SDQSQASGTTGGRRVSKALMASMARRASRG
PIAFWARRAS----RTRLA----A------------------------------------
------------------------------------WARRALL----SLRSPKARRGKAR
RRA---------------------------------------------------------
-AKLQS-SQEPEAPP-PRDVALL---QGRANDLVK------YLLAKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LKDIIKEYTDVYPEIIERAGYSLEKVFGIQLKEIDKNDHLYI-LLSTLEP
TDAGIL-GTTKDS-PKLG---LLM----------VLLSI----------IF--------M
-NGNR----S-S--EAVIWEVLRKLGLR--PGIHHSLFGDVKKLITDEFVKQK-------
---------YLDYARVPNSNP---P--EYEFFWGLRSYYETSKMKVLKFACKVQKK---D
------PKEWAAQYREAMEADLKAAAEAAA--EAKAR----AEIRARMGIGLGSE-----
----NAAGP--CNWD-------------EADIGPWA-KARIQAGAEAKAKAQESG--SAS
TGASTST------NNSA--SASASAST--SGGFSAGASLTATLTFGLFAGLGGAGASTSG
SSGACG-FSYK-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MAQKMDCGEGLLGFQA-----
--------------------------------------------------------EASV
EDRT-LLMQTLM-------EAIQ--IS-EAPPTSQA--LA--------------------
------------------------------------------AASGQTASPQCSQPPTA-
S------------------------------------------------ERAD-------
------IQVSAAAARPKT------------------------------------------
-----------------------------AF---------------KAQ-----------
-------------NAT----------------TKGSRGVYSFSKARNAKAIG-NTQPKTG
F-------------------KPRNATP--KCPNAAYD-------FSKAAAR---------
----SKLATSESEITLFKAQDVTTKVGPNP---------N-NSFSRSPNANEMVTDQPKT
------------------------------------------------------------
----------------------------------------------AFKAWNDTTKASVA
-------------------------------DTQT-------H--SQNV-----------
----NWA---KMA------------DTETN--PS---------IFEPDGAAAQTSADSSL
AQNLE--------------------S---------------------------------R
TIIHGKRTHKINNLNV---------EENICGDQMRAPLAAGTWRSAPVPVTT-QNPPGVP
PNMLWQTPLA----WQNPS----GWQNQTAGQTP----P-TRQNPPASQSPSSWQNLVAW
QNPMIWPSPIVWPGPVIWHILLLAWP----------------------------------
----------------------------------------NWPILP--------------
----------DCASQ-PRDVALL---QERANKLVK------YLMLKD-YTKVPI--RR--
------------------------------------------------------------
----SEM---LRDIIREYTDVYPEIIERASFVLEKKFGIQLKEIDKEEHLYI-LISTPE-
SLAGIL-ATTKDI-PKLG---LLL----------VILGV----------IF--------M
-NDNR----A-S--EAVLWEALRKMGLR--PGVRHPLLGDLRKLLTYEFVKQK-------
---------YLEYRRVPNSHP---P--EYEFLWGLRSYHETSKMKVLRFIAEVQRK---D
------PRVWTAQFMEAAQEALDAMDAASA--EAEAR----AEARTRMGIGDEAV-----
------SGP--WSWDDIEFELLT-WDEEGDFDDPWS-RIPF----TFWPRYNQNGHSTIP
QTFAG---------------------P--IIGPGGTSTA------N----FSAIGF----
--------FWVE------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------

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------------------------------------------------------------
---------------------------------------MSDT-----------------
---------------SE-SGT----------------------------GPTCFQAEASE
EDPG-LKMQTIL-------TVTQ--NLEASETPKAS------------------KT----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------PEVSKATKIS-------DAAGVS---------------KT------------
---------------------------------------------TAAQEVS-ATQASPT
-TKLTDTQFLAA----KK--KSLAADT--NMQHTDPQ-------AVTVSAT---------
----ETKK-----VSS--------------------------------------------
------------------------------------------------------------
--------------------------------------------------------VA--
-------------------------------DTKV-------------------------
----N-T--KTLETES--------TASQALADEP---------EP--EGAAGQAQENQDT
RPKIK--------------------A---------------------------------K
KARKVKHLNGEEDGS---------------SDQSQASGTTGGRRISKALMASMARRASRG
PIAFWARRAS----RTRLA----A------------------------------------
------------------------------------WARRALL----SLRSPKARRGKAR
RRA---------------------------------------------------------
-AKLQS-SQEPEAPP-PRDVALL---QGRANDLVK------YLLVKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LKDIIKEYTDVYPEIIERAGYSLEKVFGIQLKEIDKNDHLYI-LLSTLEP
TDAGIL-GTTKDS-PKLG---LLM----------VLLSI----------IF--------M
-NGNR----S-S--EAVIWEVLRKLGLR--PGIHHSLFGDVKKLITDEFVKQK-------
---------YLDYVRVPNSNP---P--EYEFFWGLRSYYETSKMKVLKFACKVQKK---D
------PKEWAAQYREAMEAD-----------EAKAR----AEIRAQMGIGLGSE-----
----NAAGP--CNWD-------------EADIGPWA-KARIQAGAEAKAKAQESG--GAS
AG------------------AS----T--GGNFGASTSLTATLTFGLFAGLGGAGASASG
SSGACG-FSYK-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------METQFRRGA
LGCSPASIKRKKKREDSG--DLGLQVSTMFSEDDFQST---ERAPYGPQI----------
---------QWSQDLPRVQVFRE----------QANLE---DRSPR-RTQRITGGEQV--
-----------------LWGPITQIFPTVWPADLTRVIMPLDQ-----------------
-----------------RSQ-HCKPE-E----------------GLQA----QEE-DLG-
-------------LVG-AQALQAE------------------------------------
-----------------------------------------------------------E
Q-E---------------------------------------------------------
------------------------------------------------------------
---AAFFSSTLN----VGT--LEE------------------------------------
---------LP--------------------------------------AAES---LSPP
QSPQEESF---SPTAMD-A--IFGSLSDE----------------GSSS--QEKEGP---
------------S------TLPDLI------------DPESFSQHILHDKIIDLV-----
-------HLLLRKYRVKGLIT-KAEML--GSVIKNYE-----DYFPEIFREASVC-----
----MQLLFGID---------VKE-VDPTS---------HSYV-----------------
-------L----------------------------------VTSLNL-SYD----GIQC
---NE-QSMPKSGLL-------IIVLGVIFMEGNC------IPEE---VMWEVLSTM---
-----GVY-AGR----EHFLFGEPKRLLTQDWVQE------KYLVYRQV-PGTDPACCEF
----LWGPRAHTETS--KMKVLEYIANANGRDPT----S-YPSLYED---ALREEGEGV-
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------MSEQSKD
LSD---------------------------------------------------------
------------------------------------------------------------
--------PNF----------------------------A---------------AEA-P
NSEM--------------------------HSS-----------------PGVPVG---V
P--PPASPPAT----------LAGPSSPPVGP------------T---------------
----ASPQAA--------------------------------------------------
------LPP--------------QALSEEED---------PKIL-QQA-A-EE--GR---
----------------------VYHPP----EPAQPL-PPPPAPAQLVQKAHELM-----
-------WYVLVKDQKKMIIW-FPDMV--KDVIGSYK-----KWCRSILRRTSLI-----
----LARVFGLH---------LRL-TSLHT---------MEFA-----------------
-------L----------------------------------VKALNPEELD-----RVA
----LNNRMPMTGLL-------LMILSLIYVKGRG------ARES---AVWNVLRIL---
-----GLR-PWK----KHSTFGDVRKLITEEFVQQ------NYLKYQRV-PFVEPPEYEF
----FWGSRASREIT--KMQIMEFLARVFKKDPQ----A-WPSRYRE---ALEEARALRE
ANPSA----------------------------------HCPRSSVSED-----------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
--------------------------------------MSLEQ-----------------
-----------------RSL-HYKPE-E----------------ALEA----QQE-ALG-
-------------LVCVQA-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---AASSSSPLV----LGT--LEE------------------------------------
---------VP--------------------------------------TAGS---TDPP
QTPQGASA---FPTTIN-F--PRWRQPNE----------------SSSS--HEEEGP---
------------S------TSRVL---------------ESLFRAVLTKKVADLV-----
-------RFLLLKYRAREPVT-KAEML--ERVIKNYK-----HCFPVIFGKASES-----
----LQLVFGID---------VKE-ADSTG---------HSYV-----------------
-------L----------------------------------VTCLGL-SYD----GLLG
---DN-QIMPKTGFL-------IIILVMIAMEGGR------APEE---EIWEELNVM---
-----EVY-DGR----EHSAYGEPRKLLTQDLVQE------KYLEYRQV-PYSDPARYEF
----LWGPRALAETS--YVKVLEYVIKVSARVRF----F-FPSLREA---ALREDEE--G
V-----------------------------------------------------------
------------------------------------------------------------
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------------------------------------------

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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------MPRGKK---SKLRARGKR-RET
-HD-----QLQGL-----------------------------------------------
-TG-------------PQATAEKQ------------------------------------
-----------------------------------------------------------E
-ESR-----------------------SSSSSSA-----V---------------CRGAR
RRSS----------------------------GSS-------V-------PQESQG---A
S--PTGYPDAGASCSKYDVAA----MGQDEKS------------PSTSRDASVSQESQ-G
ASPIGPPDAGISC---------SKS--------DEAAKGQNEKSPSTSRDASV-----PQ
ESQGASPTG---SPDADVS----GSKSDVAA---------------KGQ---DEESL---
-----------------------------SS-SKRAALFTTTDGDPLKRKANKMV-----
-------QFLQEKFEKKEPIL-KADML--KRLRRQYK-----PCFPEILKRTSER-----
----LTVFFGVE---------LKE-TDSSG---------ESYT-----------------
-------L----------------------------------VSKLGL-SSE----GILS
----GDNALPKSGLL-------MSILGLIFMRGNR------ATEE---EAWKFLGLL---
-----GIY-DGI----LHSIYGDARKIITEDLVQD------KYVVYRQV-CNSDPPCYEF
----LWGPRAHAETT--KMRVLRVLTEINNTSPG----L-YPHLYED---ALTDEVERAL
RLRA--------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
-------MQTLM-------EAIQ--IS-EAPPTNQA--TA--------------------
------------------------------------------AATGQNASPQSSQPPTV-
N------------------------------------------------EVAD-------
------TEASAAATRPKI------------------------------------------
-----------------------------AF---------------KAQ-----------
-------------NTT----------------TKGPNGVYDFSQAYNAKEKP-NTQAKAA
F-------------------KPQKANP--KGPNAASD-------FSQAATT---------
----GKSGAKKSEMAFKPQNTT-TKMGSSA---------P-YNFSQSASANEMASNQPKT
------------------------------------------------------------
----------------------------------------------AIKARNETTKTPTA
-------------------------------DAQP-----------QNV-----------
----NQA---KMVTSQ--------SDVEAK--PG---------ISEPDGAAAQTSADGSQ
AQNLE--------------------S---------------------------------R
TIIRGKRTRKINNLNV---------EENSSGDPRRASLASGNWRSAPVPVTT-QNPPGAP
PNVLWQTPLA----WQNPS----GWQNQTARQTP----P-ARQSPPARQTPSAWQNPVAW
QNPVIWPNPVIWQNPVIWPNPI-IWPGPIVWPNPMAWQNAPGWQTQPGWQTPPGWQGPPD
WQG---PPEWPLPPDW-PMPP-DWSFP-TDWPFPPDWIPADWPIPPDWQNLRPSPNLRP-
-SPNSRASQNQGAPQ-PRDVTLL---QERANKLVK------YLMLKD-YTKVPI--KR--
------------------------------------------------------------
----SEM---LRDIIREYTDVYPEIIERACFVLEKKFGIQLKEIDKEEHLYI-LISTPE-
SLAGIL-GTTKDT-PKLG---LLL----------VILGI----------IF--------M
-NGNR----A-T--EAVLWEALRKMGLR--PGVRHPLLGDLRKLLTYEFVKQK-------
---------YLDYRRVPNSNP---P--EYEFLWGLRSYHETSKMKVLRFIAEVQKR---D
------PRDWTAQFMEAADEALDALDAAAA--EAEAR----AEARTRMGIGDEAV-----
------SGP--WSWDDIEFELLT-WDEEGDFGDPWS-RIPF----TFWARYHQNARSRFP
QTFTG---------------------P--IIGPGGTASA------NFAANFGAIGF----
--------FWVE------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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--------------------------------------------------------MAE-
----------------------------------------------------------GS
FS-----V-Q-------SESYSVEDMDEGSDEVR--EEEMVEGNDYE----EFGAFGGYG
TLTSFDIHI--LRAFGSLG-----------------------------PGLRILSNEPWE
LENP-VLAQTLV-------EALQ--LDPDTLANETAARAA-------------NVARAAA
---S----------NRA-ARAA--------------------AAAARTAFTQV---VASH
R-------------------------------------------------VAT-------
------PQVSGEDTQPTTYAA--EAQ--------------------GPTPEPPLASPQTS
------QMLVTSEMAAPGAPVT-STKSQTGS---------------PAQ-----------
-------------EAA----------------TEGPSSACAFSQAPCAREVD-TTRPSTA
FLGQ----------------------------NDVFD-------FTQPAGV---------
----SGMAFPRPKRPAPAQEA--ATEGSSA---------AS-GVPQTGPGREVAATRPKT
T-----------------------------K-----------------------------
------------------------------------------------------------
--------------------------------------------------------SGKA
LAKTRWVEPQNVVAAA--------AAKA-KMATS---------IPEPEGAAA--ATAQHS
AE-----------------------P---------------------------------W
ARMGGKRTKKSKHLDDEY--------ESSE-EEREPPAVPPTWRASQPSLT---------
---------V----R---------------------------------------------
----------------------------------------AQLA----------------
-----------------PRRP-----------------------------V----A----
-PRSQIPSRHVLCLP-PRNVTLL---QERANKLVK------YLMIKD-YKKIPI--KR--
------------------------------------------------------------
----ADM---LKDVIREYDEHFPEIIERATYTLEKKFGIHLKEIDKEEHLYI-LVCTRDS
SAR-WE----------SS---FLF----------VILGV----------IF--------M
-NAQT----V----------------PR--GGVRHPFLGDLRKLITDDFVKQKNLELREG
TPLSVAPSWYLEYKKIPNSNP---P--EYEFLWGLRARHETSKMRVLRFIAQNQNR---D
------PREWKAHFLEAVDDAFKTMDVDMA--EEHAR----AQMRAQMNIGDEAL-----
------IGR--WSWDDIQVELLT-WDEDGDFGDAWA-RIPF----AFWARYHQYILNSNR
ANRRA------TWRAGVSSGTNGGASTSVLDGPSTS-ST---IRTRNAARAG--------
----ASFFSWIQHR----------------------------------------------
------------------------------------------------------------
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-----------------------------------------------------MSEQSKD
LSD---------------------------------------------------------
------------------------------------------------------------
--------PDL----------------------------T---------------AET-P
SREV--------------------------HSS-----------------PGVPAG---G
P--APVSPAAT----------LAGPQSPPPGP------------T---------------
----ALSQPE--------------------------------------------------
------PPP--------------QAPSDEDD---------PKAL-LQA-A----------
--------------------------------------------EQLVQKAHELM-----
-------WYVLVKDQKKMIIW-FPDMV--KDVIGSYK-----KWCRSILRRTSLI-----
----LARVFGLH---------LRL-TSLHT---------MEFA-----------------
-------L----------------------------------VKALDPEELD-----RVA
----LSNRMPMTGLL-------LMILSLIYVKGRG------ARES---AVWNVLRIL---
-----GLR-PWK----KHSTFGDVRKLITEEFVQQ------NYLKYQRV-PYVEPPEYEF
----FWGSRATQEIT--KMQIMEFLARVFKKDPQ----A-WPSRYRE---ALEEARALRE
ASPSV----------------------------------HCPRSSVSED-----------
------------------------------------------------------------
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---------------------M-------SLVSQNARR----------------------
------------------------------------------------------------
------------------GSAETT------------------------------------
-----------------------------------------------------------G
-DY---------------------------------------------------------
-----------------------------------------------------------S
D--GQGEMQA----------------SNASGS------------P-T-------------
---------------------------------------------------SM------L
----------VPQALQ----GPHAPINPQGA---------------SASQ-AA-------
---------QDP----N--DLEV--LIE-EQSQRLGA---LRVHDPLEDRSIALV-----
-------NFMRMKSQTEGSIQ--QAEM--LEFLREYS-----DQFPEILRRASAH-----
----LDQVFGLT---------LRV-LDPQA---------DIYN-----------------
----------------------L-------------------ISKRGY-QNT----DRIA
----ESLDVPKAGLL-------ALVLGHILLNGNR------ARES---SIWDLLLKV---
-----DLL---GDPQRINNLFGNTRNLLITDFVRM------RFLEYWPV-YGTNPLEFEF
----LWGSRAHR--EITKM-----------------------------------------
------------------------------------------------------------
--------------------------E-------------------------------AL
K-----------------------F---VA----------------EAHDEEP-------
------------------------WSWPE-EYN------------KALEADKAKER---R
---------------------------------------------------------QA-
AG---L--------E-FWSED---TMNDKANDLVQ------LAINVT-EELLPI--HQ--
------------------------------------------------------------
----DEL---LAHTGKEFEEVFPNILSRATLILDLFYGFSLIEVDTSEHIYL-LVQQPES
EEEQMM-LESLGR-PTQE---YVM----------PILGL----------IF--------L
-MGNR----V-K--EANIWNLLRRFGVD--VGRKHAI--------TCKLMRQR-------
---------YLECRPLSYSNP---V--EYELLWGPRAHLETTKMKALEYMAGLYRK---R
------PQDWPEQYREAVE-----------DEEARARSEATAMFF----FGP--------
---M--------------------------------------------------------
------------------------------------------------------------
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-----------------------------------------------------P------
-------VSAP-----------QGVP--CPSIIWQAPKGQPPIPHE--------------
------------------------------------------------------------
------------------------------------------------------------
---------LPTSMEFQEVQP-TQ-AV--AWQAPKAP-----AHFWQPIPAQEVQRQ---
----APTVVQLE-------QPFQGAPPSQKVLQVQL-PAQQAQPS--GPEAELPVLQHQP
SWEGPPAVLQAQAGAPVASTNFPRGSSKSLMTP-SGESRASSVEHRGSSSKE----RKTS
SK--DRRGPPKDRV----------ILAATFCAPRA----MPATRAHLPNTWRNVPGTSET
FTATSRAF-PAT----SPFQPASSYAFPGPSLTPE----APRSLPFPL---QDPFACAEG
LPAGAWAPQPHVNASQASKAVPTILM-ATAAAPE----A-TATS-PE---ASKT-VEPPR
RS-----------------------GKA--------------------------------
--TRK-----KKHLEAAE-DSRGHTLA-------------------------------FR
--D-WQGH----RPWENVN--LSAW--EVQSPIR-A--LGEWEHPGISHGLNGWEGPSTS
-RV---------------LSG---WEGPSTSWALSAWEGPSTSR-A--------------
---------LVAS---------------EGPGSPHSLIMSEVP-------------C---
LSQGSS--QDNPKVE-TQHLSPL---DERADALVQ------FLLVKD-QAKVPI--QR--
------------------------------------------------------------
----SEM---VKVIIREYKDECLDIINRANNKLECAFGCQLKEIDTINHSYV-IVNKLGH
PKGNLV-SSCLHK-PKLG---LLV----------VVLSL----------IF--------M
-KGNC----V-R--EDLIFSFLYRLGVD--VREVNGLFGNTKKLITEVFVRQK-------
---------YLEYRRIPHTDP---A--EYELLWGPRAFLETSKMLVLRLLAKFHKK---T
------PQCWPLHYLEALAECESEDDDGDG-DDD-SDSGDNP-------GNP--------
---TSSPPPS--------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
---------------------M-------SLVSQNARR----------------------
------------------------------------------------------------
------------------GSAETT------------------------------------
-----------------------------------------------------------A
-DY---------------------------------------------------------
-----------------------------------------------------------S
D--GQGEMQA----------------SNASGS------------P-T-------------
---------------------------------------------------SM------L
----------VPQALQ----GPHAPINPQGA---------------SAFQ-AA-------
---------QDP----N--DLEV--LIE-EQSQRLGA---LRVQDPLEDRSIALV-----
-------NFMRMKSQTEGSIQ--QAEM--LEFLREYS-----DQFPEILRRASAH-----
----LDQVFGLN---------LRV-LDPQA---------DIYN-----------------
----------------------L-------------------ISKRGF-QTS----DQLA
----ESLDVPKAGLL-------ALVLGHILLNGNR------AREA---SIWDLLLKV---
-----DLL---GDPQRINNLFANTRNLLITDFVRM------RFLEYWPV-YGTNPLEFEF
----LWGSRAHR--EITKM-----------------------------------------
------------------------------------------------------------
--------------------------E-------------------------------AL
K-----------------------F---VA----------------EAHDEEP-------
------------------------WSWPE-EYN------------KALEADKAKER---R
---------------------------------------------------------QA-
AG---L--------E-FWSEE---TMNDKANDLVQ------LAINVT-EELLPI--HQ--
------------------------------------------------------------
----DEL---LAHTGKEFEEVFPNILSRATLILDLFYGFSLIEVDTSEHIYL-LVQQPES
EEEQMM-LDSLGR-PTQE---YVM----------PILGL----------IF--------L
-MGNR----V-K--EANIWNMLRRFGVD--VGRKHAI--------TCKLMRQR-------
---------YLECRPLSYSNP---V--EYELLWGPRAHLETTKMKALEYMARLYRK---R
------PQDWPEQYREAVE-----------DEESRARSEATAMFF----FSP--------
---M--------------------------------------------------------
------------------------------------------------------------
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------------------------------------------

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------------------------------------------------------------
--------------------------------------MPRGQK---SKHRAHEKH-RQA
-QA-----ETQGL-----------------------------------------------
-HD--------------QATTSGE------------------------------------
-----------------------------------------------------------E
-ETT-------------------------SSSPP-----D---------------SESSP
STLS-A-------------------------AGI----------------SKGPQG---A
Q--GTTSAAAGAIRKRSGVRRA--------------------------------------
------------------------------------------------------------
--------ARSRSVV------------GVGA---------------EG-Q-VQEGE----
-----------------------------NS-SQASAAAESSHTDLLTWKAEMLV-----
-------QYMLCKYKARELIK-RSEML--KAVTRRYR-----EQFPEILSRASER-----
----MELVFGLV---------LKE-VRPNS---------HCYT-----------------
-------L----------------------------------VSNLDL-SDS----ESMR
----GDWGLPKNGLL-------MPLLGVIYLNGHH------ASEE---EIWKFLNIL---
-----GIY-DGR----SHFIFGEPRKLITEDLILA------KVK--DLV-PDALLPHYEE
----AWREEV--ESS--RTRGLALLAKVKDLVPD----A-LLPHYEE---AWREEVESSR
TRAVA-GTSPSALAS-----VG---PSASASVG---------------------------
-----------------------PSA----------------------------------
-S--------------------ASAGPSARPVLAL-----LP------------------
------------------------------------------------------------
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------MHSQLNLERAKDK-----------------------------------------
------------------------------------------------------------
------------------G-------------------------------------I---
---------QEEIL----LGEQRRENETGSALARG-TGAMAQKMDCGAGLLGFQ------
-------------------------------------------------------AEASV
EDST-LLMQTLM-------EAIQ--IS-EAPPTNQA--T---------------------
-------------------------------------------AAGPNASPQNSQPPTA-
S------------------------------------------------EMAD-------
------IQALAAAARPKT------------------------------------------
-----------------------------AF---------------KAQ-----------
-------------NAP----------------TKGPNGAYDFSQALNAKEMP-NAPPKAA
F-------------------KSQNPTP--KGPNAAYD-------FSQAATT---------
----SELTANKSETAFKAQNA--TKVGPNT---------T-YNFSQSLSASEMANTQPKT
------------------------------------------------------------
----------------------------------------------AFKAWNDTTKTPTV
-------------------------------DTQT-----------QNI-----------
----NQA---KMATNQ--------PEVET--NPG---------IPESDGAAAQTSADGSQ
AQNLE--------------------S---------------------------------R
TIIRGKRTRKINNLNV---------DENSSGDQRRAPLATGTWRSAPVPVTT-QNPPGAP
PNVLWQTPLA----WQNPS----GWQNQPARQTP----P-ARQSPPARQTPPAWQNPVAW
QNPVIWPNPVIWQNPVIWPNPI-VWPGPVVWPNPLAWQNPPGWQTPPGWQNPPGWQGPPD
WQG---PPDWPLPPDW-PLPP-DWPIP-TDWPLPPDWIPTDWPVPPDWQNLRPSPNLRP-
-SPNSRASQNLGASQ-PRDVALL---QERANKLVK------YLMLKD-YTKVPI--KR--
------------------------------------------------------------
----SEM---LRDIIREYTDVYPEIIERACFVLEKKFGIQLKEIDKEEHLYI-LISTPE-
SLAGIL-GTTKDT-PKLG---LLL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPLLGDLRKLLTYEFVKQK-------
---------YLDYRRVPNSNP---P--EYEFLWGLRSYHETSKMKVLRFIAEVQKR---D
------PRDWTAQFMEAADEALDALDAAAA--EAEAR----AEARTRMGIGDEAV-----
------SGP--WSWDDIEFELLT-WDEEGDFGDPWS-RIPF----TFWARYHQNARSRFP
QTFAG---------------------P--IIGPGGTASA------NFAANFGAIGF----
--------FWVE------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
--------------------------------------MPRGQK---SKLRAREKR-RQN
-RA-----EAQGL-----------------------------------------------
-KS-------------AQAATAEE------------------------------------
-----------------------------------------------------------E
-AT--------------------------ASSPP-----V---------------TGDGA
SSSS-V-------------------------AGS----------------LQAPAR---V
S--AA-ASAAAG------------------------------------------------
------------------------------------------------------------
-----------------VS----CRRSDVHA---------------KS-R-VQ-KSE---
-----------------------------NS--QAAPSSESSGHDLLTRKAGMLM-----
-------HFLLCKYKMNEPIK-KGDML--KVIHKRYR-----EHFPEILKKASER-----
----MDLVFGLE---------LKE-VKPNG---------HSYS-----------------
-------L----------------------------------VCKLDD-SRD---EST-S
----NALRFPTKVIL-------MPLLGLIFLNGNR------ASEE---EIWELLNIL---
-----GVY-DEE----THCILGEPRDIITQNLVQE------KYLEYRQV-PGSDPPRFEF
----LWGPRAQAETT--KGKVLDFLCKVNDTFPT----D-FPPHYEE---LLRDEKERAR
------------------------------------------------------------
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------------------------------------------------------------
------------------------------MPR---------------------------
----------------------KHKNK-------------------------------NH
--------------------AHGKRY-QVQGDTQE---AQAS--AAAAPG-----EECL-
-SS---------------PSFVPQVSSQS-SV---AAGNHQELQ-G-------------A
---------MAPS---S-------------TVAEASCAGSEEG-------------TQGP
KEES ADAAQAALVTR-SIRKDTL---IKKASM VMD------FLLERY-IMKEPI--TQ--
------------------------------------------------------------
----DAM---LEVIGSKFKQHFPEILSRASERVELLFGLELKEVDCSRNIYT-LVNKFSL
GVEEGS-SDEEEL-PKSG---LLM----------ALLGI----------IF--------M
-KGNR----A-T--EEEIWEFLNVLGIH--AGKKHSIFGEPRKLITKDLVQKG-------
---------YLNYRQVPNSDP---P--GYEFLWGPRAYAETTKMKVLEVLAKIQET---V
------PSSFPDLYDEALRDQVERAALGGT-ARAPAMAEASASTRAKSY------SSSHI
------------------------------------------------------------
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------------------------------------------------------------
---------------------------------------MAQKMDCGEGLLGFQA-----
--------------------------------------------------------EASV
EDRT-LLMQTLM-------EAIQ--IS-EAPPTSQA--LA--------------------
------------------------------------------AAS----GPQCSQPPTA-
S------------------------------------------------ERAD-------
------IQVSAAAARPKT------------------------------------------
-----------------------------AF---------------KAH-----------
-------------NAT----------------TKGSRGVYSFSKARNAKAIG-NTQPKTG
F-------------------KPRNATP--KCLNAAYD-------FSKAAAR---------
----SKLATSESEITLFKAQDVTTKVGPNP---------N-NSFSRSPNANEMVTDQPKT
------------------------------------------------------------
----------------------------------------------AFKAWNT-TKASVA
-------------------------------DTQT-------H--SQNV-----------
----NWA---KMATSQ--------ADTETN--PS---------IFEPDGAAAQTSADSSL
AQNLE--------------------S---------------------------------R
TIIHGKRTHKINNLNV---------EENICGDQMRAPLAAGTWRSAPVPVTT-QNPPGVP
PNMLWQTPLA----WQNPS----GWQNQTAGQTP----P-TRQNPPASQSPSSWQNLV--
------------------------------------------------------------
------------------------------------------------------------
---------NMSASQ-PRDVALL---QERANKLVK------YLMLKD-YTKVPI--RH--
------------------------------------------------------------
----SEM---LRDIIREYTDVYPEIIERASFVLEKKFGIQLKEIDKEEHLYI-LISTPE-
SLAGIL-ATTKDI-PKLG---LLL----------VILGV----------IF--------M
-NDNR----A-S--EAVLWEALRKMGLR--PGVRHPLLGDLRKLLTYEFVN---------
-------------------HP---P--EYEFLWGLRSYHETSKMKVLRFIAEVQRK---D
------PRVWTAQFMEASQEALDAMDAASA--EAEAR----AEARTRMGIGDEAV-----
------SGP--WSWDDIEFELLT-WDEEGDFDDPWS-RIPF----TFWPRYNQNGHSTIP
QTFAG---------------------P--IIGPGGTSTA------N----FSAIGF----
--------FWVE------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------M-------SLVSQNARR----------------------
------------------------------------------------------------
------------------GSAETT------------------------------------
-----------------------------------------------------------A
-DY---------------------------------------------------------
-----------------------------------------------------------G
D--RQGEMQA----------------SDASGS------------P-T-------------
---------------------------------------------------SM------L
----------VPQALQ----GPHALINPQDA---------------SASQ-TA-------
---------QDP----N--DLEV--LIE-EQSQRLGA---LRVHDPLEDRSIALV-----
-------NFMRMKSQTEGSIQ--QAEM--LEFLREYS-----DQFPEILRRASAH-----
----LDQVFGLN---------LRV-LDPQA---------DVYN-----------------
----------------------L-------------------ISKRGF-QTT----DRIT
----ESLDVPKAGLL-------ALVLGHILLNGNR------AREA---SIWDLLLKV---
-----DLL---GDPQRINNLFGNTRNLLITDFVRM------RFLEYWPV-YGTNPLEFEF
----LWGSRAHM--EITKM-----------------------------------------
------------------------------------------------------------
--------------------------E-------------------------------AL
K-----------------------F---VA----------------EAHDEEP-------
------------------------WSWPE-EYN------------KALEADKAKER---R
---------------------------------------------------------QA-
AG---L--------E-FWSED---TMNDKANDLVQ------LAINVT-EELLPI--HQ--
------------------------------------------------------------
----DEL---LAHTGKEFEEVFPNILSRATLILDLFYGFSLIEVDTSEHIYL-LVQQPES
EEEQMM-LDSLGR-PTQE---YVM----------PILGL----------IF--------L
-MGNR----V-K--EANIWNMLRRFGVD--VGRKHAI--------TCKLMRQR-------
---------YLECRPLSYSNP---V--EYELLWGPRAHLETTKMKALEYMARLYRK---R
------PQDWPEQYREAVE-----------DEEARVRSEATAVFF----FGP--------
---M--------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
-------------------------------------------------------DEASV
EDSA-LLMQTLM-------EAIQ--IS-EAPPTNQA--TA--------------------
------------------------------------------AASRQNASPQSSQPPTV-
C------------------------------------------------EMAD-------
------IQVSTADARPKT------------------------------------------
-----------------------------AF---------------KAQ-----------
-------------NAI----------------TKGSNGAYDFSQALHAKEMP-NIPPNAA
Y-------------------KYQNA-------NAAYD-------FSQAATT---------
----NELTANKSEIAFKVQNTA-TMVGPSA---------T-YNFSPSLSASEMANTQPKA
------------------------------------------------------------
----------------------------------------------AFKAWNDSSKVPVA
-------------------------------DAQA-----------QII-----------
----NQG---KMISSQ--------ADIEAD--PG---------VSESDGATAQTPTDGSQ
AQNLE--------------------S---------------------------------R
TIIRGKRTRKINNLNV---------EDNNSGDQRRAPLSTGTWRSAPVPITT-QNPPGAP
PNVLWQTPLA----XXXXX----XXXXXXXXXXX----XXXXXXXXXXXXXXXXXXXXXX
XXXXX--XXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXX-XXXXX-X-XXX-XXXXX-X
XXX---XXXXXXXXXX-XX---XXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-
-XXXXXXXXXXXXXX-XXXXXXX---XXXXXXXXX------XXXXXXXXXXXXX--XX--
------------------------------------------------------------
----XXX---XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXX----------XXXXX----------XX--------X
-XXXX----X-X--XXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXXXXX-------
---------YLDYRRVPNSNP---P--EYEFLWGLRSYHETSKMKVLRFIAEVQKR---D
------PRDWTAQFMEAADEALDALDAAAA--EAEAR----AEARTRMGIGDEAV-----
------SGP--WSWDDIEFELLT-WDEEGEFGDPWA-RIPF----TFWARYHQNARSRFP
QTFAG---------------------P--IVGPSSTASA------NFAANFGAIGF----
--------FWVE------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------MPR---------------------------
----------------------GNKSK---------------------------------
-SR-----------------SRAKRQ-QARVESQN---LQGTRPTAEEE--------AA-
-AP-------------------PRG-QGE-APSSPDVCTPQASQ-E-------------A
---------ASLD---F-------------PELDIPYSGYDAG---------AEGSVAGV
DEKRANACIIAEAID-SARRDPM---TRKASKVLH------YLLEKY-QKDEQP--TE--
------------------------------------------------------------
----ADM---LKLISRKYKVHFPWILEKATYQLEVVYGLELKADKHNSQSYV-LVSKLPI
PPGDNE-GGMRDL-PKTG---LIL----------TLLGM----------IL--------M
-KGER----A-S--EEEVWQFLHMQGIY--PGRRHLIFGEPRKFITEELVEQN-------
---------YVEYRQVPGSNP---P--SYEFLWGSRARNEETKMKVLDVLAKIRNA---M
------PSFYPQQYEEALSNQAERAASRDE-ASGYHAA---RVPA----HAHSSSYSHT-
------------------------------------------------------------
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-----------------------------MGLSTSRVAITLKPQDPMEQNVAELL-----
-------QFLLVKDQSKYPIR-ESEMR--EYIAKEYR-----SQFPEILRRAAAH-----
----LECIFRFE---------LRE-LDPET---------RTYI-----------------
-------L----------------------------------LNKLGPVPFE-----GLE
----ESPNGPKMGLL-------MMILGQIFLNGNQ------AKEA---EIWEMLWRM---
-----GVQ-RER----RLSIFGNPKRLLSVEFVCT------CPRIQG-----LGRI----
------------------------------------------------------------
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--------------------------------------MPRGQK---SKLRAREKR-RRN
-RG-----ETQGL-----------------------------------------------
-VS-------------AQATTGEG------------------------------------
-----------------------------------------------------------E
-KAT-------------------------PSSSP-----V---------------SGDAS
SGSP-V-------------------------PGT----------------SQEPQK---G
L--AT-TSAAAH------------------------------------------------
------------------------------------------------------------
-----------------VS----RPRSNGGA---------------KR-Q-VK-ERK---
-----------------------------NS-FQASTSIESVRKDPLTKKVGMLV-----
-------QFLLYKYKLQEPIK-KADML--KIIHKRYR-----EHFPEILRKASER-----
----MELVFGLE---------LKE-VKPGG---------HSYT-----------------
-------L----------------------------------VSSLDL-TAD---GRV-S
----SAWGFPKNGLL-------MPLLGVIFLNGNR------TSEE---EIWEFLNIL---
-----GIH-DGR----RHFIFGEPRKLITQDLVQE------KYLEYRQV-ANSDPPRYEF
----LWGPRAHAETS--KMRVLEFLAKIHDTVPS----A-FPPHYEE---ALRDEEERAR
AR-ATAGAAST-TR----------------------------------------------
----------------------------------------------------------AG
--------------------ARS--Q-----------------------AKSG-LSSP--
P-----------------------------------------------------------
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--------------------------------------------------MLQTPE---S
G--------------------------------------------------GLPVP----
-------QAE----------------------------GEKDGGHDGETRAPT-----A-
-SQE-------------------RPKEELGA---------------GREE-G--------
----------------AVEPALTRKGA--RA-LAAKALARRRAFRRLNRTVAELV-----
-------QFLLVKDKKKSPIT-RSEMV--KYVIGDLK-----ILFPDIIARAAEH-----
----LRYVFGFE---------LKQ-FDRKH---------HTYI-----------------
-------L----------------------------------INKLKPLEEE--------
EEEDLGGDGPRLGLL-------MMILGLIYMRGNS------AREA---QVWEMLRRL---
-----GVQ-PSK----YHFLFGYPKRLIMEDFVQQ------RYLSYRRV-PHTNPPEYEF
----SWGPRSNLEIS--KMKVLGFVAKLHKKEPQ----H-WPVQYRE---ALADEADRAR
AKAR-AEASMRARA--------SARA------G---------------------------
------------------------------------------------------------
-IH----L------W---------------------------------------------
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--------------------------------------MPRGHK---SKLRTCEKR-QET
-NG-----QPQGL-----------------------------------------------
-TG-------------PQATAEKQ------------------------------------
-----------------------------------------------------------E
-ESH-----------------------SSSSSSR-----A---------------CLGDC
RRSS----------------------------DAS-------I-------PQESQG---V
S--PTGSPDAVVSYSKSDVAA----NGQDEKS------------PSTSRDASVPQESQ-G
ASPTGSPDAGVSG---------SKY--------DVAANGQDEKSPSTSHDVSV-----PQ
ESQGASPTG---SPDAGVS----GSKYDVAA---------------EGE---DEESV---
-----------------------------SA-SQKAIIFKRLSKDAVKKKACTLA-----
-------QFLQKKFEKKESIL-KADML--KCVRREYK-----PYFPQILNRTSQH-----
----LVVAFGVE---------LKE-MDSSG---------ESYT-----------------
-------L----------------------------------VSKLGL-PSE----GILS
----GDNALPKSGLL-------MSLLVVIFMNGNC------ATEE---EVWEFLGLL---
-----GIY-DGI----LHSIYGDARKIITEDLVQD------KYVVYRQV-CNSDPPCYEF
----LWGPRAYAETT--KMRVLRVLADSSNTSPG----L-YPHLYED---ALIDEVERAL
RLRA--------------------------------------------------------
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--------------------------------------MSRY------------------
----------------GKHP-RLSLE-Q-------------NG-SFQI----PDE-PD--
--------------EFPLVPTAEKEERQEKEEVKEEEKEDTN-----TQKNEED------
---NNEKEEE----------------------------------------EEECGDEVHE
EENEK----------EEEESDTASIFTPPSPSSSSSSSSSSSSS---------------S
---SSS---------------------------------------S-------SSSSSSS
SSSSSSSIYSLF----QSN--LEGNA----------------------------------
---------GY--------------------------------------APGI---LSIF
QNAQSFFP---SS--------ILGVDLDE----------------TSSND-EES--S---
------------G------ASQSSE------------DPEALLDAVIQEKATDLV-----
-------FLFIYKYRMKEPIT-LSEIH--EVVTKDYE-----NHFPVIFMEASKC-----
----LEMTFGID---------IKQ-SDLLS---------SAYV-----------------
-------F----------------------------------VNSLNL-TYE----DTLS
---DN-DRLPRNAFL-------IVILGVIFIEGNC------ASEE---RIWEFLKLV---
-----GVH-DGE----EHFICGDPREFLTINLVQE------NYLEYRQV-PNSQPPCFEF
----LWGPRAYAETT--KMKVLEFLAKMNGCDPT----D-FSVWYEE---ALRDEEERAW
ATRDSEDGSPT-------------------------------------------------
------------------------------------------------------------
-----------------------MW------LAE----------------R---------
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------------------------------------------MA----------------
-----------------PRPP-----------------------------M----A----
-LRSQVPSRHVLCLP-PRNVTLL---QERANKLVK------YLMIKD-YKKIPI--KR--
------------------------------------------------------------
----SDM---MKDVIREYDEHFPEIIERATYTLEKKFGIHLKEIDKEEHLYI-LVCTRDS
SAR-LL-GKTKDT-PRLS---LLL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPFLGDLRKLITEDFVKQK-------
------------------------------------------------------------
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--------------------------------------------------MLQTPE---S
R--------------------------------------------------GLPVP----
-------QAE----------------------------GEKDGGHDGETRAPT-----A-
-SQE-------------------RPKEELGA---------------GREE-G--------
----------------AVEPALTRKGA--RA-LAAKALARRRAYRRLNRTVAELV-----
-------QFLLVKDKKKSPIT-RSEMV--KYVIGDLK-----ALFPDIIARAAEH-----
----LRYVFGFE---------LKQ-FDRKH---------HTYI-----------------
-------L----------------------------------INKLKPLEEE--------
EEEDLGGDGPRLGLL-------MMILGLIYMRGNS------AREA---QVWEMLRRL---
-----GMQ-PSK----YHFLFGYPKRLIMEDFVQQ------RYLSYRRV-PHTSPPEYEF
----SWGPRSNLEIS--KMKVLGFVAKLHKKEPQ----H-WPVQYRE---ALADEADRAR
AKAR-AEASMRARA--------SARA------G---------------------------
------------------------------------------------------------
-IH----L------W---------------------------------------------
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--------------------------------------MP--------------------
---------LFPTLP------GLSFE-A----------------DFPN----PSV-IQD-
-------------L----------------------------------------------
-------------------------------------------------VDAQDS--IDE
EEEDAS----------------------STSPSSFHFSFPSSSSSSS----------S--
------------------------------------------------------------
------SPSTLI----LGA--PE-----------------------DEDMPAASPP---E
IPPQGPPKISP--------------------------------------QGPP---QSPP
QSPLNSCS--------S-P--LLWTRLDE----------------ESSSE-EEED-T---
------------A------TWQAL------------PESESLPRYALDEKVAELM-----
-------QFLLLKYQTKEPVP-KAEML--ATAIKQYN-----DYFPMIFGKAREL-----
----IELIFGIS---------LTE-MDPDN---------HSYF-----------------
-------F----------------------------------EDRLGL-TYE----GS--
LI-DD-QGMPQNCLL-------ILILSMISIKGSC------VPEE---VLWEVLSAI---
-----GVC-AGR----EHFIYGNPRKLLTIDWVQR------KFLEYREV-PNSAPPRYEF
----LWGPRAHSEAS--KRKVLEFLAKLSSIIPS----S-FPSGYMD---ALKDVEDRAQ
AIIDTTDDA-T-------------------------------------------------
------------------------------------------------------------
-----------------------AT------ASA----------------SPS--V----
------------------------------------------------------------
---------TST---------------------NVCP-----------------------
------------------E-----------------------------------------
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----------------------------------MDRRNDYGYRMPTFQSKHSNGEEKS-
GNNYRRIPWGRRPPP-PRDVAIL---QERANKLVK------YLLVKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LKDVIQEYEEYFPEIIERASYALEKMFRVNLKEIDKQNSLYI-LISTQES
SAG-IL-GTTKDT-PKLG---LLM----------VILSV----------IF--------M
-NGNK----A-S--EAVIWEVLRKLGLR--PGVRHSLFGEVRKLITDEFVKQK-------
---------YLEYKRVPNSRP---P--EYEFFWGLRSYHETSKMKVLKFACKVQKK---D
------PKDWAAQYREAVEMEVQAAAVAVA--EAEAR----AEIYS--PRLRILL-----
------VAAV-FPLE--------------------P-CYSL----GIFVCTAV-------
------------------------------------------------------------
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--------------------------------------MPRGQK---SKHRARDKR-RET
-HG-----QPQGL-----------------------------------------------
-TG-------------PQTTAEKQ------------------------------------
-----------------------------------------------------------E
-EPH-----------------------SSTVSSP-----D---------------YRGAH
PKSS----------------------------DAS-------F-------PQESQG---A
S--PTGSPDAAVSCSKSDVAA----KGQDEKN------------ASTSPNASVPQESQ-R
ASPAGSLDAGASC---------SKS--------DVAAKGQDEKNASTSPNASV-----PQ
ESQRASPTG---SLDAGAS----CSKSDVAA---------------KGQD-EKNESA---
-----------------------------IA-SHRAAFFKTTDRDPLNRKARVLV-----
-------QFLQEKFEKKEIIL-KADML--KRINRKYK-----VYLPEILKKTSNH-----
----LAVVFGVE---------LKE-MDSSG---------ESYT-----------------
-------L----------------------------------VSMLGL-SSE----GILS
----GVNGLAKSGIL-------MSLLSFIFIRGNC------AIEK---EVWDFLSVL---
-----GIY-DGV----VHSIYGEPRKIIMEDLVQD------KYLEYWQV-CDGDPPCYGF
----LWGPRAHAETS--KMSVLRALANINNTVPG----F-YPHLYEE---ALIDEAQRAL
RLRA--------------------------------------------------------
------------------------------------------------------------
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------------------------------MPR---------------------------
----------------------GQKSK-------------------------------LR
--------------------ARKKRQ-QTRSVAQG---AKAAHAVGEEEEESP-SSSPV-
---------------------LLEDIPRS-SSAAVSGTPPPRPS-S-------------P
---------P-ST---S------------TTSGRVPDTRPHEG------D-----DSQGE
EEQ QPPSSGVTPSAD-RSHSDAL---ATKVDLLEQ------FLLYKY-KMKQPI--MK--
------------------------------------------------------------
----ADM---LMVVNTKCPHLFAEILQGASRSIEALFAVEVKEINSTCQSYD-LVSKLKL
PNNGRV-RPGRGL-PKTG---LLM----------TLLGV----------IF--------M
-KGNR----A-T--EEDVWKFLNTMRIY--AGRKHFIYGEPRKLITKDLVRLQ-------
---------YLEYRRLPDTDP---A--RYEFLWGPKAHAETSKMKVLEFVAKARDT---V
------PTAFPSQYEEALRDQEERARVGTA-ATPGATARA------RLRSCTCPAASSLL
------------------------------------------------------------
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--------------------------------------MPRGHK---SKARAREKR-RQL
-QD-----EAQGL-----------------------------------------------
-KD-------------AQAKADEN------------------------------------
-----------------------------------------------------------E
-EST-------------------------SSSAH-----D---------------SGDAV
ASTS-T-------------------------ASF----------------PQKSKS---L
G--EAP------------------------------------------------------
------------------------------------------------------------
----------PITAGKRVA----RRRSGKGA---------------KG-R-REQSAS---
-----------------------------CC-SKAPQSAESLQNELVTRKAGLLM-----
-------QYLLCMYKMKQPMN-KGEML--KVINKRFR-----EQFPEILKKASER-----
----IELVFGLE---------VKQ-LKPNG---------SYYT-----------------
-------L----------------------------------VRKLDP-SIG----GTLA
----TGLPFPQNGLL-------MPLLSVIFLNGNR------ASEV---EIWEFLNIL---
-----GIY-DGK----VHTIFGEPRHLITKVLVKE------KYLEYRRV-ADSEPPGYEF
----LWGPRAYAETT--KMKVLEFLAKVNETVPQ----S-FPSHYEE---ALRDEEERAK
AEAV-GKC----------------------------------------------------
-----------------------------------------------------------G
--------------------TTATN------------------------------KA---
------------------------------------------------------------
------------E-----------------------------------------------
------------------SKVTP---G-DSSC----------------------------
------------------------------------------------------------
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------------------------------------------

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--------------------------------------MSHSS-----------------
-----------------KRP-RLTFE-P----------------NFQA----QSE-VM--
------------------------------------------------------------
-----------------------------------------------FPIPED-------
-EN-SSISS------CS---------------------FSF-------------------
---------------------------------------------------------SYP
STSPPS--SPVI----QGS--LEEEE-EK-------------------------------
-----DATS------------------------------------------------RRP
QSPQ---R----------S--MAWSTSGG----------------GSSNQ-DNEDTS---
-------------------SLQTSA------------FPESLCRDRIDDNVTNLV-----
-------HAMILRYRLRKPIT-KAEML--QVVNKRDK-----SQFSVIFKKACKS-----
----LEVICGID---------VKE-VVPAT---------HSYV-----------------
-------L----------------------------------VNSLDL-TYD----EM--
LS-DP-QSMPKNGLL-------IIILGMIFLEGNC------APEE---DIWEFLNMM---
-----GVY-AGR----EHFIYGEPRNLITRTWVQE------NYLEYQQV-LNSDPPRYQF
----MWGPRAHAETS--KLQVLEFLAKIKGTDPI----S-FSCWYEE---ALRDEQERAQ
ARIGPVGHAAA-------------------------------------------------
------------------------------------------------------------
-----------------------MF------MAQ----------------PLL--P----
------------------------------------------------------------
---------------------------------QRKN-----------------------
------------------EHE---------------------------------------
------------------------------------------------------------
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------------------------------MPR---------------------------
----------------------GNKSK---------------------------------
-SR-----------------SRAKRQ-QARGESQS---LQGALPTAKEE-----------
---------------------------GD-APSSPDVIGAES------------------
--------------------------------SDAGAE GSDVG---------AELSVAGV
DEKRANACTIAEAID-SARRDPM---TRKASKVLH------YLLEKY-QKDEQP--LE--
------------------------------------------------------------
----A DM---LKLISRKYKVHFPWILEKATYQLEVVYGLELKADKQNPQSYV-LVSKLPI
LPGANE-GGRKEL-PKTG---LIL----------TLLGM----------IM--------M
-KGDR----A-S--EEEVWQFLHMQGIY--PGRRHLIFGEPRKFITKELVEQN-------
---------YVEYRQVPGSNP---P--SYEFLWGSRARNEDTKMKVLDVLTKIRNA---M
------PSYYPQQYEEALSNQAERAARRGE-ASGYHAA---RVPS----HFHSTSSSHT-
------------------------------------------------------------
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------------------------------------------

------------------------------------------------------------
------------------MSL--VSQNPRRRRNAKAA-----------------------
----------ARNGSGDEMQAPSARSLPAAMPGPDVPQDRSDPQLLQ-GLGAE-------
---EG-----------------AGT------------SALPT------------------
---------------PGEGPST---------SVQSTAA---EGSSACGQLSI-SEG-PNT
SELPGP---------------S-QG----PSTFGPPAVS---------------------
-----EGPNTAVSITASEGPS------TSGPPTAAEGSKA---SE-------HLTVSEGL
TI----------------------S-EVPRSDEGLSALAQSTL--------GAGPSTSVP
PTFAEESGIS-------------------LLLASGEGPSTS-------LP--PTVSEGLG
IYVPSPTSEVSS--------SS---VL-----PTASDG------------QG---ISMLP
T------SGEGPSAPVPLPVSEEPGVSMRPSSG---------------EGLSTS------
------------------------------------------------------------
------------------------------------------GLPPSGDGHSTWVPPTIL
KGSGVYV---------PPTSVEGLSTAVP---------------PTACESASA-------
------------------------------------S---------------AEGQSTFM
----------QSS----------------------------------------------A
AEGCSTS---------VQPR----------------------------------------
------------------------------------------------------------
----------------------------AVEGPGTCMLLP---------------CGEGP
ST-SQMP--LA------AEGPS-TSGMPTAAES---------------------------
---PDAVLD---------------------------------------------------
------------CGA------VGTDFCKCASLALPK------------------------
-----------------------PPAPSVRP---------------K-------------
-------RSDGPVEFQVLRDSENSNAITIMGLGTAHVALTLKPQDPMEQNVAELL-----
-------QFLLVKDQSKYPIR-ESEMR--QFIVKEYR-----NQFPEILRRAAAH-----
----LECIFRFE---------LRE-LDPEE---------HTYI-----------------
-------L----------------------------------LNKLGPVPFE-----GLE
----DSPNGPKMGLL-------MMILGQIFLNGNQ------AKEA---DIWEMLWRF---
-----GVQ-RER----RLSIFGNPKRLLSVEFVWQ------RYLDYRPI-TDCTPVEYEF
----YWGPRSHLETT--KMKILKFMAKIYNRDPM----D-WPAQYNE---ALEEDAIRAA
ADD---------------------------------------------------------
------------------------------------------------------------
----WQPVPHFRRPFFEE----------VSPE------------------LLA-PD----
-SD---------------------------------------------------------
---------LPGY-------------------------P---------------------
---------SKYPPH-SWPESRL---ESKSRKLVQ------LFLLMD-STKLPI--PK--
------------------------------------------------------------
----KGI---LYYIGRECSKVFPDLLNRAARTLNHVYGTELVVLDPRNHSYT-LYNRREM
EDTEEI-VDSPNR-PGNN---FLM----------QVLSF----------IF--------I
-MGNH----A-R--ESSVWAFLRGLGVQ--NGRKHVI--------TCRYLSQR-------
---------YIDSLRVPDSDP---V--QYDFVWGPRARLETSKMKALRYVARIHRK---D
------PQDWPEQYREAMEDEANRAEAGHR-QL----------LVHNLR-----------
------------------------------------------------------------
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------------------------------------------------------------
----------MSPHP------FPNDG-D----------------DPEN----PGA-IED-
-------------S----------------------------------------------
-------------------------------------------------ADAQIP--TDD
EDSS-------------------------MSS-SYTYVFPLSPC----------------
------------------------------------------------------------
------L-SSED----EEG--EK-EEEL----------------SAGMSSLPPSTP---S
S----PPQNPS--------------------------------------QGSP---QSPP
QNPMSSSS--------S-S--VSWSPVSG----------------ESSSQ-KEED-T---
------------S------TFQCL------------SDSESLFTNTLDEKVAEVV-----
-------QFLLLKYEAKEPVT-EAEML--MIVL-SYQ-----DYFPIILEKAREF-----
----MELLFGLA---------LIE-VDPD----------HSYA-----------------
-------F----------------------------------ADTVDP-TDQ----GS--
-S-DD-QGTPKYSLL-------ILILSIIFIKDGC------ASEE---AIWEVLNAI---
-----GVY-AGR----EHFVYGEPGELLTKVWVEE------QYLEYREV-PNSSPPRYDF
----LWGPRAHSESR--KRKVLEFLAKLNNTVPN----S-FPSWYKD---ALKNVGERAQ
AIISTKDDA-T-------------------------------------------------
------------------------------------------------------------
-----------------------QG------Q----------------------------
------------------------------------------------------------
------------------------------------------------------------
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----------------------------------------------------------RS
LLNPRYSLPGSTVVITGCH-CYPCRFLFFTMPR---------------------------
----------------------GQKSK-------------------------------SR
--------------------SRAKRQ-QARSELQG---LPAVHH--TAAEAAS-PPA---
----------------------DQSDGSS-FP---VGCTLQGVK-T-------------P
---------GSLS---A----------------DVSCTGSGVG---------VRNAVVLA
DKQSSDTTQVVSSIQ-HSLKDPI---MRKASVLIE------FLLDKF-KMKEAV--TR--
------------------------------------------------------------
----SEM---LAVVNKKYKEQFPEILRRTSARLELVFGIELKEIDPNTHTYM-LVGKLGL
STEGSL-SSNWGL-PRTG---LLM----------SILGV----------IF--------M
-KGNR----A-S--EQEVWQFLNGVGVY--AGKKHLIFGDPEEFINKDLVQEN-------
---------YLEYRQVPGSDP---P--TFEFLWGPRAHAETTKMKVLEVLAKVNGT---V
------PSAFPNLYQLALRDQAGGARRRDQ-SR-SR-------------SHK--------
------------------------------------------------------------
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--------------------------------------MPRGQK---SKLRAREKR-RQA
-HG-----ETLGL-----------------------------------------------
-QG-------------AQAPAAAE------------------------------------
-----------------------------------------------------------D
-KIL-------------------------S-SSL-----V---------------FEGTP
QNSS-Y-------------------------AGS----------------PQGPQR---S
P--FTTTS----------------------------------------------------
------------------------------------------------------------
--------------AAAIS----CITSDEGA---------------KG-Q-DEESPS---
------------------------------S-FQVPASTKSSRKDPLTRKA---------
----------------------EADML--KIVNRKYK-----DHFPEILKRTSER-----
----MELIFGLD---------LKQ-EDSRG---------QSYA-----------------
-------L----------------------------------VSKLDL-TNE----ENLS
----GAWGFPKSGLL-------MPLLGVIFINGNC------ATEE---EIWEFLNML---
-----GIY-DGK----RHFIFGDTRKLITRDLVRE------KYLEYRQV-PNTDPPRYEF
----LWGPRAHAETS--KMKVLEFLAKVNDTVPS----A-FQSRYEE---ALRDEEARAG
A-RVAGRA-------GSIAISCLLSLTIFSMPR---------------------------
----------------------GKKSK-------------------------------LR
--------------------TREKHR-NTHNKTQS---LKDAQATAAKGEKFP-SSSPP-
--------------------V-LEGTPQN-S---LAASICRGPQ-R-------------P
---------PSTT---T-------------LTVAISYTSADEA-------------AKGW
DEESPSS SQAQSSTE-ISHKDPL---TRKASM LVQ------FLLYKY-KMKEPN--MK--
------------------------------------------------------------
----SDL---LKIVNRKYKDHFSEILRRTSEHMEVVFGIDLKKDDSTRHLYT-LASKMNL
PNNGRL-NRDRGL-PKTG---LLM----------TLLGV----------IF--------M
-KGNH----A-A--EEEIWEFLNKMKIY--EGKRHFLFGDARKLIMEDLVQER-------
---------YLEYQQVCHSSP---P--RYEFLWGPRAYAETSKMKVLEFLAKINHT---V
------PSTFLSRYEEALRDEEERSGVRVA-ARTDTTEGIF-----NMLFLLSKGLFSII
--------IY--------------------------------------------------
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--------------------------------------------------MSQIPR---S
R--------------------------------------------------GRPSA----
-------FAL----------------------------ADRERERGR------------G
GDHPSPSADVSEE----------APSTSRGP---------------DA------------
-----------------------------RA-VPAAPAVGPRTQKQLELKVAELV-----
-------QFLLVKDQKKIPIK-RTDIL--KHVVGDYK-----DVFPELLRLAAGR-----
----LRDVFGYE---------LVE-LEPRS---------NAYI-----------------
-------L----------------------------------VNTLEPVEED----AEVR
----GDQGTPAAGLL-------MIVLGLIFMKGNT------ITET---EVWDFLRRL---
-----GVY-PTK----RHLIFGDPKKLITEDFVRQ------RYLEYRRI-PHTDPVDYEL
----QWGPRTNLETS--KMKVLKFVAKIHNQDPK----D-WPVQYCE---ALMDEENRAR
PPSS-APAPSS-------------------------------------------------
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------------------MSQ--LSKNLGDSSPPAEAPKPP-------------------
----------VYSRPTVLMRAP-----PASSRAPPVPWDPPPMDLQAASLAAWQAPQPAW
EPPQGQLPAPV---ASLVQPPALGG-LVQAPPLGGPMGKPPT------------------
---------------PGVLMVQPPPPPGAPMPQPPAPGVLMVHPSATGAPVAHPPP-PGN
PMSHPP-------------------------PPGAPM-----------------------
--------------------------------------------A-------HAPPPGTP
------------------------MAHP--PPPGTPMAHAPPPGTPMVPPPPPGTPMAHP
PPPGTP--MA-------------------HPPPPGTPMAQP---PAPGVLMAQPLTPGVL
MVQPP-------------APGAPMAQPL---PPAALM-------------------SQPP
PSAAPMAKPPGPGVLMIHPSGAGAPITQPPVSG---------------APMAQTVPP---
----PTQPMASWAPQGQPLILQIQSQVI----R-------APPPV---P-----------
-------Q---GPPTPQVQLATTPGWQATAPGWQGPPQGWQATPLTWQATQVTWQAPT--
----------IAWQAPPPI-RQGPPPIRP-------------GPPPIRPGPPPV------
------------------------------------------GRQTPPV-------IRQA
-AP---------V-----------------------------------------------
--------IRQAAPLIRQAPP-PI------------------------------------
-----------------------------------------------------------R
--------------SAPQVLATQPQLWQALPPPP-----P---------------LRQAP
QARLLAPQVQG------------APLVPTAPMLTP-------VPAGPGAGPQVPQP---V
L--PTPLSVP----------------------------------------LPAPLP----
-APQTAPQAAPQASQ-------QAVQ--CPSIIWQAPKGQSPVQHE--------------
------------------------------------------------------------
------------------------------------------------------------
---------LPTSMEFQEVQQ-AQ-EM--AWQAPKVP-----THFWQPLPAQEGQEQ---
----PPSIVQLE-----Q-QPFRGALASQKGLQTQL-PTHEAQPT--GPQAEMPAMQLQS
SWQGPPTMLQAPPGAPVAGENFPRGQAKSLLTP-SGECRASSSEPKGSS-KE----RRTS
SK--EKKGPPKDRM----------IFTGTFCAPRA----MSASRAHLPNAWKNLPTTSGA
FYATSRVF-PST----SHFQP----AFKGPSATTA----SPKSRPLAL---QDPYPCIEA
LPAAPWMLQPNGDVSKSSKAASSIPM-ATEAVPQ----A-SA---TE---ASKT-VDPPR
RS-----------------------GKV--------------------------------
--TRK-----KKHLEPKE-DNRGPRVA-------------------------------SR
--E-WQGS----WSWENSS--PSDW--EFQSSVQ-V--LGDWEGPSTSYGLNGW------
-------------------------EEPSTSWALSPWEGPSTSK-G--------------
---------LGHC---------------EGSGSPQPFTVSEVP-------------C---
LSHRHWASQEDPMEE-TQQLSPL---EERANALVQ------FLLVRD-RAKGPI--LR--
------------------------------------------------------------
----SEM---VNVIIREYKDEYLEIISRANTKLECNFGCQLKEIDSNTHSYV-IVNKLGH
PQCDLW-ASFIDK-PKFG---LLM----------VVLSL----------IF--------M
-KGNC----V-R--ENLIFNFLFRLGLD--VRETNSLFGNMKKLITEVFVRHR-------
---------YLEYRRIPCTEP---A--EYELLWGPRAFLETSKMLVLRFLAKLHNR---D
------PRCWPFHYLEALAEFESEVSDEDE-PDT----SGDT-------GDP--------
---TSRRPPR--------------------------------------------------
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--------------------------------------MPRGQK---SKLRAREKR-QET
-HG-----QPQGL-----------------------------------------------
-TG-------------PQVTAEKQ------------------------------------
-----------------------------------------------------------E
-ESH-----------------------SSSSSSH-----D---------------CLGTR
RRSS----------------------------DAS-------V-------PQESQG---V
S--PTGSPDAVVSCLKSDVAA----KGQDEKS------------PSTSPDASISQESQ-G
ASPTGSPDAGVSC---------SKS--------EVAVKGQDEKSPSTSPDASI-----SQ
ESQGASPTG---FADAGVS----GSKYDVAA---------------KGQ---DEESV---
-----------------------------RA-SQKAIIFKRLSQDPLKRKACALV-----
-------QLLQEKFEKKESIL-KADML--KRVGKRYK-----HYFPEILNRTSER-----
----LAVAFGVE---------LKE-MDSSG---------ESYT-----------------
-------L----------------------------------VSKLGL-SSE----GILN
----DAKGLRKSGLL-------MSVLGVIFMKGNC------ATEE---EVWEFLSCL---
-----GIY-AGM----THPIYGDPQKLITEDLVQD------KYVVYRQV-RNSDPPRYEF
----LWGPRAHAETT--KMRVLRVLAKSNNTSPG----L-YPHLYED---ALMDEVERAL
RLRA--------------------------------------------------------
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--------------------------------------MADSH-----------------
-----------------NIQ-YCNLQ-E----------------SAQA----QQE-----
-------------LDNDQET----------------------------------------
------------------------------------------------------------
--------------------------------------MVTS------------------
------------------------------------------------------------
---QEEE-VTTT----SNK--V--------------------------------------
----------Y--------------------------------------GSGI---PSPP
QSPQRAYS---PCVALA-S--IPDS------------------------P-SEEASI---
------------K------GSEGLE------------DPLYLLHNAQNTKVYDLV-----
-------DFLVLNYEMKAFPT-KAEML--ESIGREYE-----EYYPLIFSEASEC-----
----LKMVFGLD---------MVE-VDPFV---------HSYM-----------------
-------L----------------------------------VTALGI-TYD----GM--
MT-DV-QGMPKTGIL-------IAVLSVIFMKGNY------VSEE---IIWEMLNNI---
-----GLC-GGR----NPYIHKDPRKLISEEFVQE------GYLEYRQV-PNSDPPSYGF
----LWGPRAFAETS--KMKVLQFFASINKTHPR----A-YPEKYAE---ALQDEIDRTK
AWILNRCSNFS-------------------------------------------------
------------------------------------------------------------
-----------------------DL-------------------------LT---F----
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--------------------------------------MSQG-Q----------------
-----------------EIP-SCTQE-Q-----------------HDA----PSE-IQG-
-------------LEAAQVSKAVE------------------------------------
-----------------------------------------------------------E
T-----------------------------------------------------------
------------------------------------------------------------
---SPS-PCPVM----PGN--MEEA---V---------------------AAG-------
----------T--------------------------------------SSTA-------
QSPQSAYP---SYAVLT-A--VSPSKSDE----------------GSSSQ-EKEDSS---
------------S-------SSSLS------------DFENFPIDPLDEKVTMLV-----
-------QLLLHKYRTKEPIT-RADMI---DVIKVCN-----DDFPEILRKAAER-----
----MELVFGID---------MNE-VDPTS---------HTYV-----------------
-------L----------------------------------VNKLGL-TYY----PSLS
---GE-DNMPKTSLL-------IIVLGVIFMKGNC------ATEE---EIWEVLNMM---
-----DLY-CGR----KHFIFGEPGKFITQDLVQE------EYLEYRQV-ANSDPPRCEF
----LWGPRAHAEAS--KMKLLEFLTRIHESDPR----C-FPSQYQE---ALRDEAMRAR
ARSATKAGTSA-------------------------------------------------
------------------------------------------------------------
-----------------------EA--------G----------------TSA----KA-
------------------------------------------------------------
---------GTS---------------------AMGS-----------------------
------------------TQPS------AGS-------------------------GS--
------------------------------------------------------------
----SSQ---P-------------------------------------------------
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--------------------------------------MPRGQK---SKQRAREKH-QHV
-QG-----ETQGL-----------------------------------------------
-KG-------------AQATAVEE------------------------------------
-----------------------------------------------------------E
-EF--------------------------PSSST-----V---------------LGDTP
QSSP-I-------------------------ASI----------------LQEPQR---V
P--ATTTLAAAA------------------------------------------------
------------------------------------------------------------
-----------------TL----CEEPDESA---------------KS-Q-DE-ESP---
-----------------------------SP-SQATPSTVSSRKDPLARKTNKLV-----
-------QFLIEKFKKKEPIM-KADMV--KVINKKYE-----EQFPEILKRTTKH-----
----MELVFGLG---------LKE-TDPSD---------NSYD-----------------
-------L----------------------------------ISKLDS-TQG---GSL-C
----SGGGLPKTGLL-------MTLLGLIFLKGNR------LTEK---AIWEYLNVL---
-----GIY-AAR----RHLIFGEPRKSITRDLVQE------KYLEYQQV-PNSDPPCYEF
----LWGPRAQAEAT--KMKALEFLAKMNDTVPS----S-FPALYEE---ALRDEEERAG
AI-VAATAGPT-AT----------------------------------------------
----------------------------------------------------------AS
--------------------ASS--R-----------------------AKSS-SF----
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--------------------------------------------------QKPPPP---A
R--------------------------------------------------GRPGR----
------------------------------------------------------------
-SAQTPPTRRKVE----------GPGTPWGP---------------DGAG-A--------
------------------G----------------GRPRRRRSQKQLEVKVAELV-----
-------QFLLIKDQKKMPVK-RTELL--RHVVGDYK-----DVFPDLLRLAAQR-----
----LEYVFGYR---------LVE-LEPKS---------STYV-----------------
-------L----------------------------------VNTLEPVEED----AEVR
----GDQGTPGAGLL-------MIVLGLIFMRGHT------IKET---EVWDFLRRL---
-----GVH-PTK----RHSVFGDPKKLITEDFVRQ------RYLEYRRL-PHTDPVDYEL
----QWGPRTNLETT--KMKVLKFVAKIHNQDPK----D-WPVQYCE---ALADEAARAR
PQPG-VPAPSS-------------------------------------------------
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--------------------------------------MDQAS-----------------
-----------------KKS-CKKNN-S--------------------------------
------------------------------------------------------------
-------------------------------------------------------K----
FEEG----------------------------VA-------------------------Q
RKMEGF---------------------------------------LDAQDLKAKKEVATS
------------------------------------------------------------
--------------------------------------------------------VFPS
SPMLLXXX---XXXXXX-X--XXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXX---
------------X------XXXXXX------------XXXXXXXXXXXXXXXXXX-----
-------XXXXXXYRMKQPVS-KAEVL--NRIVKNYT-----NYFPVIFRRAYEC-----
----MQLVFGID---------IKE-MGPSG---------HSYV-----------------
-------L----------------------------------VPTMGL-TYD----GR--
VG-DI-LNMPKIGLL-------INILGVIFVDGNC------APEE---DIWEVLNAM---
-----GVY-AGQ----EHFIYGEPRKLITQHWVQE------GYLVYRQV-HNSNPPRYEF
----LWGPRAHAETS--KMKILTFLAKVNDTIPS----A-LPTWFEE---ALKDEEAR--
------------------------------------------------------------
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--------------------------------------MPRGQK---SKLRAREKR-QRT
-RG-----QTQDL-----------------------------------------------
-KV-------------GQPTAAEK------------------------------------
-----------------------------------------------------------E
-ESP-------------------------SSSSS-----V---------------LRDTA
SSSL-A-------------------------FGI----------------PQEPQR---E
P--PTTSAAAA-------------------------------------------------
------------------------------------------------------------
-----------------MS----CTGSDEGD---------------KS-Q-DE-ENA---
-----------------------------SS-SQASTSTERSLKDSLTRKTKMLV-----
-------QFLLYKYKMKEPTT-KAEML--KIISKKYK-----EHFPEIFRKVSQR-----
----TELVFGLA---------LKE-VNPTT---------HSYI-----------------
-------L----------------------------------VSMLGP--ND---GNQ-S
----SAWTLPRNGLL-------MPLLSVIFLNGNC------AREE---EIWEFLNML---
-----GIY-DGK----RHLIFGEPRKLITQDLVQE------KYLEYQQV-PNSDPPRYQF
----LWGPRAHAETS--KMKVLEFLAKVNDTTPN----N-FPLLYEE---ALRDEEERAG
AW-PRVAARHG-TIAM--------------------------------------------
--------------------------T--------------------------------S
--------------------AYS--R-----------------------ATSS-SSSHPM
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---MGT----EAPVVKAVILHCLPSCPHSCLLTPTRVIMSQD-Q----------------
-----------------ESP-RCTHD-Q----------------HLQT----FSE-TQS-
-------------LEVAQVSKALE------------------------------------
-----------------------------------------------------------K
T-----------------------------------------------------------
------------------------------------------------------------
---FLSSSHPLV----PGK--LKEA---P---------------------VAK-------
----------A--------------------------------------ESPL-------
EVPQSFCS---SSIAIT-A--TSSSESDE----------------ASSSQ-EEEDSP---
------------S------SSEDTS------------DPRNVPADALDQKVAFLV-----
-------NFMLHKYQMKKLIT-KADML--KIIIKDDE-----SHFSEILLRASQC-----
----LEMIFGLD---------VIE-VDPTT---------HCYG-----------------
-------L----------------------------------FIKLGL-TYD----GMLS
---GE-KGMPKTGLL-------ILILGVIFMKGNR------ATEE---EVWEVLNLT---
-----GVY-SGK----KHFIFGEPRELITKDFVKE------KYLEYQQV-ANSDPARYEF
----LWGPRAKAETS--KMKVVEFVAKVHGSYPH----S-FPSQYAE---ALKDEEERAR
ARI---------------------------------------------------------
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--------------------------------------MPRGQK---SKLRAREKR-RET
-HC-----QLQDL-----------------------------------------------
-TG-------------PQVTAEKQ------------------------------------
-----------------------------------------------------------E
-ESR-----------------------SSSSSSA-----V---------------CRSAC
RRSS----------------------------DSS-------V-------PQESQG---A
S--PTGSPDARVSCSKSDVAA----KGQDEKI------------PSTSPDTSLPQESQ-G
ASPTGSPDAGVSC---------SKS--------DMAAKGQDEKSPSTSPDASV-----PQ
ETQGASPTG---SPDAGIS----GSKYDVAA---------------KGQ---DEESL---
-----------------------------RA-SQKAIIFKRLSQDPLKRKACALV-----
-------QLLQEKFEKKESIL-KADML--KRVGKRYK-----HYFPEILNTTSER-----
----LAVAFGVE---------LKE-MDSSG---------ESYT-----------------
-------L----------------------------------VSKLGL-SSE----GILN
----DANGLQKSGLL-------MSVLCVIFMEGNR------ATEE---EVWEFLSCL---
-----GIY-AGM----THPIYGDPQKLITEDLVQD------KYVVYRQV-GNSDPPRYEF
----LWGPRAHAETT--KMKVLRVLAKSNKTSPG----L-YPHLYED---ALMDEVERAL
RLRA--------------------------------------------------------
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--------------------------------------MSRY------------------
----------------GKHP-RLSLE---------------EGVNLQN----PTE-T---
-----------DEVMFPVVPTPEEEEREGDEEVQQEEEENTN-----EQENEDD------
---NNEKEEE-EE----EEK---------------------------EEEKEESDDQVNE
EEDET----------GE--EDLTSIFLSSSNVSLATFSPPSPSS---------------S
---SSC---------------------------------------S-------S-FSSSS
SSSSSSSLFSLF----QSN--LVENE----------------------------------
---------GF--------------------------------------AVGM---LGIF
QNAHSFFP---SP--------TLGGNLDE----------------GVDSE-EES--S---
------------G------VISSPE------------DPGSLLDTIIQEKATDLV-----
-------FLFIYKYRMKEPIT-LSEIH--EVVTKEYE-----NHFPVIFTEASKC-----
----LEMTFGID---------IKE-SDLLS---------SAYV-----------------
-------F----------------------------------VNSLNL-TYE----DVLG
---DT-DRLPRNAFL-------IVILGVIFIEGNC------ASEE---RIWEFLKLV---
-----GVY-DGE----EHFICGDPREFLTTHLVQQ------NYLEYREV-PNTQPPCFEF
----LWGPRAYAETT--KMKVLEFLAKMNGCDPS----D-FSVWYEE---ALRDEEERAW
ALNNSANRSPN-------------------------------------------------
------------------------------------------------------------
-----------------------MW------FVE----------------R---------
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------------------------------------------------------------
------------------MSQ--LGTNTGDSSPPE-SPIPP-------------------
----------AHNRPTVLMRAP-----PASSRAPPVPWDPPPVDLQA-PLAAWQAPQPSW
EAAEGQLPASM---AQLAQPPALGAPMVQAPPLGGAMARPPT------------------
---------------PGVLMVHQ-PPPGAQVAQPSTPGVLMLHPSVPGAPLAHPPP-PGT
PMTHPP-------------------------SPGTPMAH---------------------
-----PLPGTPMAHPPS---------------------------------------PGTP
------------------------MTHP--PSPGTPMAHPLSPGNPMVHPLSPGTSMVHP
PQPGTSLPLT-------------------HAPIPGTPMAQP---ATPGVLMAQQLSPGVL
MVQPA-------------APAAPMVQPP---PQPALM-------------------S-HS
TASLTTMAKTGPGVVVIHSPGARAPIIQPPVSV---------------APMAQPVLS---
----PGQTLASWAPQSQPLILQIQSQVI----R-------TPQQV---P-----------
-------P---IPSTPQIQLATTPGWQALTPSWQVTPQGWQSTPLNWQATQLTWQAPA--
----------IAWQASSPG-RQGSQTVRP-------------GPTPIRPGPPP-------
------------------------------------------------IHRQIPPVIRQT
-PQ---------V-----------------------------------------------
--------MRQTP-LLRQSHT-AI------------------------------------
-----------------------------------------------------------R
--------------SATHGIASQHQLWQILPPPP-----P---------------LRQAP
QARLLIPRMPG------------TSHVPTASQVTQ-------IHLVPQAGPQVAQT---V
L--PGSLSIP----------------------------------------IPVP------
-------QAIPQPAP-------RAVH--CPSIIWQAPKGQPPVPQEL----PV---LEEL
PAPQEPPVPEELPVPEELP----VPEELQVS---------------EELP-VPEELP---
----------VPEELPEPEELQVPQQ------LQVP------------QEVPVPQQIQVP
-QEVPVPQQIQVPQEVPVPQQ-IQ-----------AP-----THFWQARQ----------
---------------------------------AHL-PTHQAQPT--GLQAELPSVQAQP
SW-------------------------------------------QGPP-QS----LQAQ
PG--ASRGPPKERM----------IIGATFSAPRA----ASASRAYLPAAWRNVTAPSES
LTAASRVF-PST----SHFQPASSDAFSGPSATSE----SPKSLPLPL---QDPYACVEA
LPAVPWVPYADVNAPSACNAVPTFLM-VAASAPQ----A-TATG-AE---ASKS-AEPPR
RS-----------------------GKA--------------------------------
--TRK-----KKHLEPKE-EDGGHRTA-------------------------------SR
DCD-WRGP----RPCENPR--QSDW--EIQRAMQ-L--LQDQEALNTPQGHDGWGCPNNS
-RV---------------PRG---FDGP------------STSQ-D--------------
---------QRFS---------------GGSGGSQSWMVSEVP-------------G---
VSWGPSAALEDPNGE-SQPMSPL---DERADALVQ------FLLVKD-QAKVPV--QL--
------------------------------------------------------------
----SEM---VNAVIREYKDESFDIISRANAKLEFNFGCQLKEIDTRTHTYV-IVK-TGP
PQCNMM-ASYLDR-PKFN---LLM----------VVLSL----------IF--------M
-KGYC----I-R--ENLLFSFLYQLGLD--VHETSGLFRSTKKLITSVFVRHR-------
---------YLEYRQIPFTEP---A--EYELLWGPRAFLEANRMHILRFLSTLYEN---Q
------AQTWTCQYLESLSELEYRDTN-----EEPNDSDDDS-------HDP--------
---TSSPHPH--------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------MSQ--LSKNLGDSSPPAEAPQPP-------------------
----------VYSRPTVLMRAP-----PASSRAPPA------------------------
--PPGQLPAPV---APLAQPPALGG-LVQAPPLGGPMGKPPN------------------
---------------PGVLMVQPPPPPGAPVPQPPTPGVLMVPPSASGAPIAHPPP-PGT
PLSHPP-------------------------PPGTPLAH---------------------
-----------------------------------------------------PPPPGTP
------------------------MAHP--PPPGTPIVPPPPPGTPIVPPPPPGTPIGHP
STPGTP--MA-------------------HPPPPGTPMAQP---PAPGVLMAQSMTPGVL
MVQPP-------------APGAPMTQPL---PPAALM-------------------TQPA
PSPALMAKPPAP------------------------------------------------
----VSAPVPSWVPQNQPLILQIQSQVI----R-------PPPQI---P-----------
-------Q---GPQHPQLQLPTVPGWQAASTGWQAPLQSWQATPLTWQTTQVTWQAPS--
----------IAWQAPPPM-RQGPPPIRP-------------GPPPIRPGPPPV------
------------------------------------------PRQIPPMMHQA-------
-PP---------M-----------------------------------------------
--------MRQIPPAIRQAPP-PI------------------------------------
-----------------------------------------------------------R
--------------SAQQVLTTQPQLWHGLPPPP-----P---------------LRQAP
HARLMASQVQG------------APQVPMAPIVTQ-------VPAMPPIGPQVPQP---V
L--PTPLSVP----------------------------------------LPAP------
-----------QAHH-------QAVY--CPSIIWQAPKGHPPMPHE--------------
------------------------------------------------------------
------------------------------------------------------------
---------LPTSMEFQEVQQ-AQ-AL--AWQAPKVP-----THVQQALSAQEVQGQ---
----PTRIIQVE-----Q-QPFRGALASQKGLQTQL-PTHQAQPT--GPQAEMPAIQL--
-WQGPPPTLQAQPGAPVAGANFPRDEAKSLMTP-AGECGASSSEPKGSS-KE----RRTT
AK--AKKGPPKDRT----------LFAGTFCAPRA----MSASRAHLPNAWKYLPTTSDT
FPPTSRVF-PST----SHFQPVSSNAFNGPSATSE----TLESLPLAL---QYPYACVEA
LPAVPWVLQPNENVSNSSKAEPSILM-ATEAAPA----A-TTTV-PE---TSKA-VEPPR
RS-----------------------GKA--------------------------------
--TRK-----KKHLEPEE-DNSRHRMD-------------------------------SQ
--D-WQNS----WPWENSS--LCNW--EIPNSVQGV--WGDWECPSTSYGLSSW------
-------------------------EGPSTSWARSIWEGPSTSR-G--------------
---------LDHG---------------EGSGFPQPFIASEVP-------------C---
LSHRCGDNQEDQRGE-TQQFSPL---DERANALVQ------FLLVRD-QERVPI--LR--
------------------------------------------------------------
----SEM---VNVVIQEYKDECLEIISRANTKLECNFGCQLKEIDSQTHSYI-IINNLGN
PQCDLP-ASVIDK-PKFG---LLM----------VVLSM----------IY--------M
-NGNC----I-R--ENMIFNFLFKLGLD--VRETNVLFGNLKTLITDVFVRHK-------
---------YLEYRRIPCTNP---A--EYELLWGPRAFLETSKLLVLRFLAKLHQR---D
------PQCWQFHYLEALAEFGVQNSRAHE-SEA----SDDS-------DDP--------
---TSRNRPS--------------------------------------------------
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---------------------------------------MSDA-----------------
---------------RE-NGA----------------------------GLTRFQAEASE
RDSG-SMMQTLL-------TVTQ--NLEVSETLKTA------------------KA----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------PEVSEDVKVS-------KAPGIS---------------KAT-----------
-------------EV---------------------------SKTPKAQEAA-ATQASPT
-TQLTDTQVLTA----EN--ESPTADT--TKQNPDRQ-------AVTMPAT---------
----ETKK-----VSC--------------------------------------------
------------------------------------------------------------
--------------------------------------------------------VA--
-------------------------------DMK--------------------------
----------ATETED--------IASQAPADEP---------EP--ESTAPQVQENQDT
RPKIK--------------------A---------------------------------K
KARKVKHLDGEEDGS---------------SDQSQSSGTTGGRRVSKALMASMARRASRG
PIAFWARRAS----RTRLA----A------------------------------------
------------------------------------WARRALL----SLRSPKARRGKAR
RRA---------------------------------------------------------
-AKLQA-SQEPEAPP-TRDVALL---QGRANDLVK------YLLAKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LKDIIKEYTDVYPEIIERAGYSLEKVFGIQLKEIDKNDHLYI-LLSTLEP
TDAGIL-GTTKDS-PKLG---LLM----------VLLSI----------IF--------M
-NGNR----S-S--EAVIWEVLRKLGLR--PGIHHSLFGDVKKLITDEFVKQK-------
---------YLDYARVPNSNP---P--EYEFFWGLRSYYETSKMKVLKFACKVQKK---D
------PKEWAAQYREAMEADLKAAAEAAA--EAKTR----AEIRAQMGIGLGSE-----
----NAAGP--CNWD-------------EADIGPWA-KARIQAGAEAKAKAQESG--GAS
AGASAGA------N------TSTSASA--GSSLSASASLTATLTFGLFAGLSGAGASTSG
NSGACG-FSYK-------------------------------------------------
------------------------------------------------------------
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---------------------------------------MAQKMDCGAGLLGFQSPDA--
--CRAVCHPLPQPPASTLPLSAFPT-LCDPPYSQLRDPPPVLSCYCTPLRASLAPAEASV
EDSA-LLMQTLM-------EAIQ--IS-EAPPTNQA--TA--------------------
------------------------------------------A-----ASPQSSQPPTA-
N------------------------------------------------EMAD-------
------IQVSAAAARPKS------------------------------------------
-----------------------------AF---------------KVQ-----------
-------------NAT----------------TKGPNGVYDFSQAHNAKDVP-NTQPKAA
L-------------------KSQNATP--KGPNAAYD-------FSQAATT---------
----GELAANKSEMAFKAQNAT-TKVGPNA---------T-YNFSQSLNANDLANSRPKT
------------------------------------------------------------
----------------------------------------------PFKAWNDTTKSPTA
-------------------------------DTQT-----------QNV-----------
----NQA---KMATSQ--------ADIETD--PG---------ISESDGATAQTSADGSQ
AQNLE--------------------S---------------------------------R
TIIWGKRTRKINNLNV---------EENSSGDQRRAPLAAGTWRSAPVPVTT-QNPPGAP
PNVLWQTPLA----WQNPS----GWQNQTARQTP----P-ARQSPPARQTPPAWQNPVAW
QNP------------VIWPNPI-VWPGPVVWPNPLAWQNPPGWQTPPGWQTPPGWQGPPD
WQG---PPDWPLPPDW-PLPP-DWPLP-TDWPLPPDWIPADWPIPPDWQNLRPSPNLRP-
-SPNSRASQNPGAAQ-PRDVALL---QERANKLVK------YLMLKD-YTKVPI--KR--
------------------------------------------------------------
----SEM---LRDIIREYTDVYPEIIERACFVLEKKFGIQLKEIDKEEHLYI-LISTPE-
SLAGIL-GTTKDT-PKLG---LLL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPLLGDLRKLLTYEFVKQK-------
---------YLDYRRVPNSNP---P--EYEFLWGLRSYHETSKMK---------------
------------------------------------------------------------
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--------------------------------------MPLEQ-----------------
-----------------RSQ-HCKPE-E----------------GLQA----QGE-SLG-
-------------LVGAQAPAPEE------------------------------------
-----------------------------------------------------------Q
E-T---------------------------------------------------------
------------------------------------------------------------
----ASSSSTVV----EVT--LGE------------------------------------
---------VP--------------------------------------AAES---PGPP
QSPQGAST---LRTTIR-Y--TLWSQSDE----------------DSSS--QEEEGP---
------------S------TFPDL---------------ESGFQAALSRKVAELV-----
-------RFLLLKYRAREPVT-KAEML--ESVMRNCQ-----YFFPVIFSKAFES-----
----LQLVFVIE---------LIE-VDPVG---------HLYI-----------------
-------F----------------------------------VTCLGL-SYN----GLLG
---DN-QMMPKTGLL-------IIVLAIIAKEGDC------APEE---KIWEELSVL---
-----EVF-EGR----EHSIFADPRKLLTQDFMQE------NYLEYRQV-PGGDPACYEF
----LWGPRALLETS--YVKVLYHMLKISGGPHF----S-YPPLHEW---ALREGEE---
------------------------------------------------------------
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--------------------------------------MSHSR-----------------
-----------------KRR-CFMLE-A----------------DPEA----QDD-NQG-
-------------HA---------------------------------------------
--------------------------------------------------------DTEE
EDSSLSSSN-----------------------CSSSFPS---------------------
---SSH---------------------------------------T----------SFSS
S-PFSGS-PPHL----SSS----EED----------------------------------
---------DT--------------------------------------AAGD---PVSP
ESPLGAYA---SLPAMV-S--APWSSSDA----------------CSVSS-PCGG-V---
------------N------ACQVLP------------GYQILPSGEGDNRVTNLV-----
-------NLLLFKYRMKELVT-EAEIL--NVI--QNY-----SDYAAIFSEVYEC-----
----MQLVFGIE---------LKD-VEPSN---------HAYV-----------------
-------L----------------------------------VSVLGI-SYD----GM--
LS-EV-QGVPKTGLL-------VLLLCTIFLRGGR------VPAE---DIWHMLNVM---
-----GIW-SGA----THFIYGDPRNLILGDFLQE------QYLVYQQV-PNSCPARYEF
----LWGPRVCAETS--KMKIIEFLASLSGSDPK----S-FGARYEE---ALREEEERMQ
------------------------------------------------------------
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------------------LSFRR-------------------------------------
-----------------------------------------------------------S
-EAR----------------------------------------------------GAER
RAHG-P-------------------------R-L----------------EQEAAE---G
L--------------------------------------------------TRSTS----
---PAARRAA----------------------------AAHAAQAGP----SQ-----A-
-DDVMEEAECEE------------------P---------------GPTA-TPP------
------------------MPSTSSSSS--SS-SQAQKKPAKRTEAQIQQKVNELV-----
-------QFLLVKDQKKLPIR-RADMV--KTILQDYK-----DLASVIIERAGRI-----
----LEEVFGLQ---------LRE-IDQKY---------HAYI-----------------
-------L----------------------------------INKLERLEGD-----GMK
----MDESVAKMGLL-------MVILSLIFMKGNS------ARES---LVWDVLKKL---
-----RVD-PEK----RHKTFGDVKKLVKDEFVRQ------KYLEYNRV-PHTEPPEYEF
----LWGPRAAHETS--KMQVLRFVAKIQNREPS----S-WVPQYNE---ALQDETASAS
A-----------------------------------------------------------
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--------------------------------------MSYT-N----------------
-----------------KLK-RKRVE-S----------------CFLI----PNK-KYI-
-------------LVCPKLPVIEE------------------------------------
-----------------------------------------------------------E
A-V---------------------------------------------------------
------------------------------------------------------------
------------------F--TEET---A---------------------VTH-------
----------S--------------------------------------PSMA-------
QIPQDACC---SSAVTA-A--TPRSKPGE----------------G-ASG-QEEVPS---
------------T----------------------------SRVSVLDKKAAQLV-----
-------KFLSIKYIMNESVT-QEEML--KMIIKEYK-----EHFPVIFKKACKC-----
----LEVVFGIN---------VKE-VDAIS---------HSYV-----------------
-------L----------------------------------TKILDL-TYD----GMLS
---DD-QGMPKTGLL-------IVILGVILMEGSC------VPEE---KIWKVLDML---
-----GVY-AGN----QDFICGEPRKLITRDLVQE------KYLEYHQV-PNSNPVRYEF
----LWGPRAYAETS--KMKVLKFVARVTGTDSS----S-FPSLYRG---PLMDKED-SL
ARIATEAGSSS-------------------------------------------------
------------------------------------------------------------
-----------------------CS--------T----------------S---------
------------------------------------------------------------
-----------------------------------ST-----------------------
------------------PK----------------------------------------
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--------------------------------------------------MLQKPE---S
G--------------------------------------------------ALPIP----
-------QAE----------------------------REMDGSHDGETQPLT-----A-
-SQEMS------------------PEEDLGA---------------VREE-G--------
----------------ASEPSLTPKGA--RA-LAAKTLARRRACRRLDRTVAELV-----
-------QFLLLKDRKKSPIT-RSEMV--KYVIGDLK-----DLFPEIIARAAEH-----
----LRYVFGFE---------LKQ-LDRKH---------HTYI-----------------
-------L----------------------------------INKLKPIEHE--------
-EEALRGDGPRLGLL-------MMILGLIYMKGNS------AREA---QVWAMLRRL---
-----GVR-PSK----YHFLFGYPKRLIMEDFVQL------RYLNYRRV-PHTNPPECEF
----SWGPRSNLETS--KMKVLGFVAKLHKKEPQ----H-WPVQYRE---ALADEADRAR
AGAS-V----RA----------RA--------S---------------------------
------------------------------------------------------------
-TH----L------W---------------------------------------------
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-----------------------------------------------------MSEQSKD
LSD---------------------------------------------------------
------------------------------------------------------------
--------PNF----------------------------A---------------AED-P
DTEM--------------------------QVS-----------------DAVPVG---V
P--PPAPLAAN----------LSGPSCAPEGP------------M---------------
----AAPQAS--------------------------------------------------
------PPP--------------AERFEEVD---------PKIL-QQA-A-EE--GR---
----------------------AHQPQ--SPARP--I-PAPPAPAQLVQKAHELM-----
-------WYVLVKDQKRMVLW-FPDMV--KEVMGSYK-----KWCRSILRRTSVI-----
----LARVFGLH---------LRL-TNLHT---------MEFA-----------------
-------L----------------------------------VKALSPEELD-----RVA
----LNNRMPMTGLL-------LMILSLIYVKGRG------AREG---AVWNVLRIL---
-----GLR-PWK----KHSTFGDVRKIITEEFVQQ------NYLKYQRV-PHIEPPEYEF
----FWGPRANREIT--KMQIMEFLARVFKKDPQ----A-WPSRYRE---ALEQARALRE
ANLVA----------------------------------QAPRSSVSED-----------
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--------------------------------------MPRGHK---SKLRAREKR-RKA
-CT-----EIQGL-----------------------------------------------
-ED-------------AQATAAA-------------------------------------
-----------------------------------------------------------A
GESP-------------------------SSFCP-----P---------------FEDRP
QNVP-A------------------------SGTPS-------I-------PQAAQG----
----TSSATA-A------------------------------------------------
------------------------------------------------------------
-----------------VS----CTDSGEGA---------------NG-Q-KE-ESS---
------------------------------K-S--SKGTEGSQTDPLNKQVVLLV-----
-------QFLLQKYQKKEPIT-KADML--KFVIKRSK-----CHFNEILKRASEH-----
----MELAFGVD---------LKE-VDPTR---------HCYA-----------------
-------L----------------------------------VSKLDL-AFD----STVN
----EEEIMLKTGLL-------MIVLGVVFMKGNC------APEE---AVWEVLNMM---
-----GVY-AER----KHFIYGDPKKVITEDLVQL------EYLQYRQV-PDSDPPRYEF
----LWGPRAHAETS--KMRVLEFLAKVHDTVPS----A-FPSCYEE---AVRDEEERAQ
AR-ASARAAIA-------------------------------------------------
-----------------------------------------------------------S
--------------------VRS--G-----------------------AMAS-NFPEAK
------------------------------------------------------------
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------------------------------------------------------------
------------------MSL--VSQNSRRRRRRVAK---ATA-----------------
----------H-NSSWDEMQAPNAPGLPADMPGSDVPQGPSDSQILQ-GLCAS-------
---EG-----------------PST------------SVLPT------------------
---------------SAEGPST---------FVPPTIS---EASSASGQPTV-SEG-PGT
SLLATP---------------S-EG----LSTSGPPTIS---------------------
-----KGLCTSVTLAASEGRN------TSRPPTSSEEPST---S----------------
--------------------------V-----------------------------TSLV
PTPDEGPSTS-------------------V------------------------------
--------------------TS---VP-----PTATEG------------LST---PVPP
T------PDEGPSTSMPATPGEGPSTSVLSAAS---------------DGQSIS------
------------------------------------------------------------
------------------------------------------LVPTPGKESSTSGPLTAT
EGLSTSV---------QPTAGEGLST----------------------------------
----------------------------------------------------------SV
----------PPT----------------------------------------------P
GEEPSTS---------VPPTAT--------------------------------------
-----------------------------------------------------------E
GLST--------------------------SVPP-----T---------------PGEGP
ST-SVLP-TPS------E-GRS-TCVPPT-ASD-GS--D---T-SVP---PT-PGE----
G--PSTLVQP----------------TASDRP--------------GSSVLPNP------
---GEGPSTLFSSSA-----SADRNPSKCS-IVLPSPRVTKA------------------
----------------S------VDSDSEGP---------------K-------------
-------GAEGPIEFEVLRDCESPNSITIMGLSTSRVAITLKPQDPMEQNVAELL-----
-------QFLLVKDQSKYPIR-ESEMR--EYIVKEYR-----NQFPEILRRAAAH-----
----LECIFRFE---------LRE-LDPEA---------HTYI-----------------
-------L----------------------------------LNKLGPVPFE-----GLE
----ESPNGPKMGLL-------MMILGQIFLNGNQ------AKEA---EIWEMLWRM---
-----GVQ-RER----RLSIFGNPKRLLSVEFVWQ------RYLDYRPV-TDCKPVEYEF
----FWGPRSHLETT--KMKILKFMAKIYNKDPM----D-WPEKYNE---ALEEDAARAF
AEG---------------------------------------------------------
------------------------------------------------------------
----WQALPHFRRPFFEE----------AAAE------------------VAS-PD----
-SE---------------------------------------------------------
---------VSSY-------------------------A---------------------
---------SKYAPH-SWPESRL---ESKARKLVQ------LFLLMD-STKLPI--PK--
------------------------------------------------------------
----KGI---LYYIGRECSKVFPDLLNRAARTLSHVYGTELVVLDPRNHSYT-LYNRREM
EETEEI-VDSPNR-PGNN---FLM----------QVLSF----------IF--------I
-MGNH----A-R--ESAVWAFLRGLGVQ--SGRKHVI--------TCRYLSQR-------
---------YIDSLRVPDSDP---V--QYEFVWGPRARLETSKMKALRYVARIHRK---E
------PQDWPQQYREAMEDEANRADVGHR-QF----------FVHNFR-----------
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---------------------------------------MAQKMDCGAGLLGFQACTAVC
CPFPQPPTSTFPLSCIPHPLDLYFS----------------------------PPAEASV
EDSA-LLMQTLM-------EAIQ--IS-EAPPTNQA--MA--------------------
------------------------------------------AASG----PQSSQPPTA-
N------------------------------------------------EMAD-------
------TEVSAAAARPKT------------------------------------------
-----------------------------TF---------------KTQ-----------
-------------NAT----------------TKGPHGVYDFSQAHNAKEMP-NTQPKAA
F-------------------KPQNGTL--KGPNTAYD-------FSQAATT---------
----GELTANKSEMAFKAQNAT-TKVGPNA---------T-YNFSQSLNANEMANNQPKT
------------------------------------------------------------
----------------------------------------------AFKAWNDTTKAPIA
-------------------------------ETQT-----------QNI-----------
----NQG---KTAASQ--------TDIETD--LG---------ISEPDGAAAQTSADSSQ
AQNLE--------------------S---------------------------------R
TIIRGKRTRKINNLNV---------EESSSGDQRRAPLAAGTWRSAPVPLTT-QNTPSTP
PSVLWQTPLA----WQNPS----GWQNQTARQTP----P-ARQSPPARQTPPTWQNPVAW
QNAVIWPNPVIWQNPVIWPNPI-VWPGPVVWPNPMAWQNPPGWQTPPGWQTPPGWQGPPD
WQG---PPDWPLPPDW-PLPP-DWPLP-TDWPLPPDWIPADWPIPPDWHNLRPSPNLRP-
-SPNSRASQNPGAAQ-PRDVALL---QERVKLAKR------LLLCEPCSVQVSL--SP--
------------------------------------------------------------
----TEM---LRDIIREYTDVYPEIIERACFVLEKKFGIQLKEIDKEEHLYI-LISTPE-
SLAGIL-GTTKDT-PKLG---LLL----------VILGI----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPLLGDLRKLLTYEFVKQK-------
---------YLDYRRVPNSNP---P--EYEFLWGLRSYHETSKMKVLRFIAEVQKR---D
------PRDWTAQFMEAADEALDALDAAAA--EAEAR----AEARTRMGIGDEAV-----
------SGP--WSWDDIEFELLT-WDEEGDFGDPWS-RIPF----TFWARYHQNARSRFP
QTFAG---------------------P--IIGPGGTASA------NFAANFGAIGF----
--------FWVE------------------------------------------------
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--------------------------------------------------MLQTPE---S
R--------------------------------------------------GLPVP----
-------QAE----------------------------GEKDGGHDGETRAPT-----A-
-SQE-------------------RPKEELGA---------------GREE-G--------
----------------AAEPALTRKGA--RA-LAVKALARRRAYRRLNRTVAELV-----
-------QFLLVKDKKKSPIT-RSEMV--KYVIGDLK-----ALFPDIIARAAEH-----
----LRYVFGFE---------LKQ-FDRKH---------HTYI-----------------
-------L----------------------------------INKLKPLEEE--------
EEEDLGGDGPRLGLL-------MMILGLIYMRGNS------AREA---QVWEMLRRL---
-----GMQ-PSK----YHFLFGYPKRLIMEDFVQQ------RYLSYRRV-PHTSPPEYEF
----SWGPRSNLEIS--KMKVLGFVAKLHKKEPQ----H-WPVQYRE---ALADEADRAR
AKAR-AEASMRARA--------SARA------G---------------------------
------------------------------------------------------------
-IH----L------W---------------------------------------------
------------------------------------------------------------
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--------------------------------------MPRR-Q----------------
-----------------KSQ-LCKLE-N----------------ILQA----QRK-KQR-
-------------LVGAQLPTAEE------------------------------------
-----------------------------------------------------------K
K-AS-----------------------SFS------------------------------
------------------------------------------------------------
-----CFLSPLI----PGT--LAKV---P---------------------AAG-------
----------T--------------------------------------ANTL-------
QGPQRACS---SSTAIA-A--TPLSKSGE----------------G-SSK-QEGKRP---
------------S------TSQA---------------PLDPSSDVLYKKVGSLM-----
-------QFLGIKYITKEPVT-KADIL--RSVIKEYK-----DHYPVIFKATSEF-----
----MEVVFGID---------VKE-ADPSG---------HSYV-----------------
-------L----------------------------------TNTLNL-TYN----KMLR
---DE-RDMPKTGLL-------ILILGLIFMEGDC------APEE---KIWEVLHMM---
-----KVY-DGM----QDIVYGEPRKLITQDFVRK------KYLVYQQV-AGSDPPRYEF
----LWGPRAHAETS--KMKVLEYFTRINGIGTS----T-FPTLYEE---ALRDEKERAW
SRIITRSHATA-------------------------------------------------
------------------------------------------------------------
-----------------------MT--------S----------------ALF----RA-
------------------------------------------------------------
---------ISS---------------------RI-------------------------
------------------------------------------------------------
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--------------------------------------MPLEQ-----------------
-----------------RSQ-HCKPE-E----------------GLEA----RGE-ARG-
-------------LVGAQAPATEE------------------------------------
-----------------------------------------------------------Q
Q-I---------------------------------------------------------
------------------------------------------------------------
----ASSSSTLV----EVT--LGE------------------------------------
---------VP--------------------------------------AADS---PSPP
HSPQGASS---FSTTIN-Y--TLWRQSDE----------------GSSN--QEEEGP---
------------R------MFPDL---------------ESEFQAAISRKMVELV-----
-------HFLLLKYRAREPVT-KAEML--ESVIRNFQ-----DFFPVIFSKASEY-----
----LQLVFGIE---------VVE-VVPIS---------HLYI-----------------
-------L----------------------------------VTCLGL-SYD----GLLG
---DN-QIMPKTGLL-------IIVLAIIAIEGDC------APEE---KIWEELSML---
-----EVF-EVG----EDSVFEHPRKLLMQDLVQE------NYLEYRQV-PGSDPACYEF
----LWGPRALIETS--YVKVLHHTLKMGGEPHI----S-YPPLHEW---ALREGEE---
------------------------------------------------------------
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-------------------------------------MMPHGQ-----------------
-----------------RSQ-DSNLE-G----------------DYST----QSG-AQV-
-------------FVDVQGLEETV------------------------------------
-----------------------------------------------------------E
EETAATAS----------------------------------------------------
--SASC------------------------------------------------------
------PSYNVI----RTT--PRE------------------------------------
---------AP--------------------------------------GLGT---LSCL
QNSQGISC---PPSATV-S--SQKNQCSE----------------GSSRQ-EKRGSR---
------------P------LWD-------------MDVPRFLRNVLLNDKLRKLV-----
-------SFLLCKYQKKEQTT-LEEML--HVVDDDYR-----EHLLLTFRELCES-----
----ICLGFGIE---------VKE-VDPPG---------HTYV-----------------
-------L----------------------------------VPVLGL-TYN----GILD
-D-DD-QIIAKFDLL-------IYTLTAVFMRGNQ------VSEK---VLKKQVIKW---
-----GML-ALR----EHIVIGEPWKFITEDLVRE------EYLVYQRV-PNSDPARYEF
----LWGPRAHAETT--QMKLLEHVAQLNRADPR----S-YPQLYNQ---ALREENGMFR
AHEGQNV-----------------------------------------------------
------------------------------------------------------------
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---------------------------------------MAQKMDRGAGLLGFQVRSPNH
FFFHTVCHPLPQPPASTLPPSAFPT-LCDPPYSQPRDPPSLLSCYCTPRYS----AEASV
EDSA-LLMQTLM-------EAIQ--IS-EAPPTNQA--TA--------------------
------------------------------------------A-----ASPQSSQPPTA-
N------------------------------------------------EMAD-------
------IQVSAAAARPKS------------------------------------------
-----------------------------AF---------------NVQ-----------
-------------NAT----------------TKGPNGVYDFSQAHNAKEVP-NTQPKAA
F-------------------KSQNATP--KGPNAAYD-------FSQAATT---------
----GELAATKSEMAFKAQNAT-TKVGPTA---------T-YNFSQSLNANDMANNRPKT
------------------------------------------------------------
----------------------------------------------PFKAWNDTTKAPTA
-------------------------------DTQT-----------QNV-----------
----NQA---KMATSH--------ADIETD--PV---------ISEPDGATAQTSADGSQ
AQNLE--------------------S---------------------------------R
TIIRGKRTRKINNLNV---------EENSSGDQRWAPLAAGTWRSAPVPVTT-QNPPGAP
PNVLWQTPLA----WQNPS----GWQNQTARQTP----P-ARQSPPARQTPPAWQNPVAW
QNPVIWPNPVIWQNPVIWPNPI-VWPGPVVWPNPLAWQNPPGWQTPPGWQTPPGWQGPPD
WQG---PPDWPLPPDW-PLPP-DWPLP-TDWPLPPDWIPADWPIPPDWQNLRPSPNLRP-
-SPNSRASQNPGAAQ-PRDVALL---QERANKLVK------YLMLKD-YTKVPI--KR--
------------------------------------------------------------
----SEM---LRDIIREYTDVYPEIIERACFVLEKKFGIQLKEIDKEEHLYI-LISTPE-
SLAGIL-GTTKDT-PKLG---LLL----------VILGV----------IF--------M
-NGNR----A-S--EGEW--------LD--LQVRHPLLGDLRKLLTYEFVKQK-------
---------YLDYRRVPNSNP---P--EYEFLWGLRSYHETSKMKVLRFIAEVQKR---D
------PRDWTAQFMEAADEALDALDAAAA--EAEAR----AEARTRMGIGDEAV-----
------SGP--WSWDDIEFELLT-WDEEGDFGDPWS-RIPF----TFWARYHQNARSRFP
QTFAG---------------------P--IIGPGGTASA------NFAANFGAIGF----
--------FWVE------------------------------------------------
------------------------------------------------------------
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------------------------------------------

------------------------------------------------------------
------------------MSL--VSQNSRRRRRRVAK---ATA-----------------
----------H-NSSWDEMQAPNAPGLPADMPGSDVPQGPSDSQILQ-GLCAS-------
---EG-----------------PST------------SVLPT------------------
---------------SAEGPST---------FVPPTIS---EVSSASGQPTV-SEG-PGT
SLLATL---------------S-EG----LSTSGPPTIS---------------------
-----KGLCTSVTLAASEGRN------TSRPPTSSEEPST---S----------------
--------------------------V-----------------------------TSLV
PTPDEGPSTS-------------------VQSTPGEGPSTS-------V-----------
----------------------------------------------------T---PVPP
T------PDEGPSTSMPATPGEGPSTSVLSAAS---------------DGQSIS------
------------------------------------------------------------
------------------------------------------LVPTPGKESSTSGPLTAT
EGLSTSV---------QPTAGEGLS-----------------------------------
---------------------------------------------------------TSV
----------PPT----------------------------------------------P
GEEPSTS---------VPPTAT--------------------------------------
-----------------------------------------------------------E
GLST--------------------------SVPP-----T---------------PGEGP
ST-SVLP-TPS------E-GRS-TCVPPT-ASD-GS--D---T-SVP---PT-PGE----
G--PSTLVQP----------------TASDRP--------------GSSVLPNP------
---GEGPSTLFSSSA-----SADRNPSKCS-IVLPSPRVTKA------------------
----------------S------VDSDSEGP---------------K-------------
-------GAEGPIEFEVLRDCESPNSITIMGLSTSRVAITLKPQDPMEQNVAELL-----
-------QFLLVKDQSKYPIR-ESEMR--EYIVKEYR-----NQFPEILRRAAAH-----
----LECIFRFE---------LRE-LDPEA---------HTYI-----------------
-------L----------------------------------LNKLGPVPFE-----GLE
----ESPNGPKMGLL-------MMILGQIFLNGNQ------AKEA---EIWEMLWRM---
-----GVQ-RER----RLSIFGNPKRLLSVEFVWQ------RYLDYRPV-TDCKPVEYEF
----FWGPRSHLETT--KMKILKFMAKIYNKDPM----D-WPEKYNE---ALEEDAARAF
AEG---------------------------------------------------------
------------------------------------------------------------
----WQALPHFRRPFFEE----------AAAE------------------VAS-PD----
-SE---------------------------------------------------------
---------VSSY-------------------------A---------------------
---------SKYAPH-SWPESRL---ESKARKLVQ------LFLLMD-STKLPI--PK--
------------------------------------------------------------
----KGI---LYYIGRECSKVFPDLLNRAARTLSHVYGTELVVLDPRNHSYT-LYNRREM
EETEEI-VDSPNR-PGNN---FLM----------QVLSF----------IF--------I
-MGNH----A-R--ESAVWAFLRGLGVQ--SGRKHVI--------TCRYLSQR-------
---------YIDSLRVPDSDP---V--QYEFVWGPRARLETSKMKALRYVARIHRK---E
------PQDWPQQYREAMEDEANRADVGHR-QF----------FVHNFR-----------
------------------------------------------------------------
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---------------------------------------MSDT-----------------
---------------SE-SGA----------------------------GSTSFQATASE
KGSG-SRMPTLL-------TVTQ--NSEVPETLKAS------------------KA----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------PEVSEATKGS-------KASGVS---------------KAT-----------
-------------KV---------------------------SKATEAPEAA-TTKASPA
-TQLTDTQVLET----AN--KSPAADS--KAQKADLK-------AVTTPAT---------
----ETKK-----VSC--------------------------------------------
------------------------------------------------------------
--------------------------------------------------------VA--
-------------------------------DTKA-------------------------
----N-T--KVPETEA--------AASQAPKDEP---------EP--EVAAAQVQENQDT
RPKVK--------------------A---------------------------------K
KVRKVKHLDGEEDGN---------------SEQNQDSGTTGGHRVSKALMASMARRASRG
PIAFWARRAS----RTRLA----A------------------------------------
------------------------------------WARRALL----SLRSPKARRGKAR
RRA---------------------------------------------------------
-AKLQS-SQEPEAAP-PRDVALL---QGRANDLVK------YLLAKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LKDIIKEYTDVYPEIIERAGYSLEKVFGIQLKEIDKNDHLYI-LLSTLEP
TDAGIL-GTTKDS-PKLG---LLM----------VLLSI----------IF--------M
-NGNR----S-S--EAVIWEVLRKLGLR--PGIHHSLFGDVKKLITDEFVKQK-------
---------YLDYARVPNSNP---P--EYEFFWGLRSYYETSKMKVLKFACKVQKK---D
------PKEWAAQYREAMEADLKAAAEAAA--EAKAR----AEIRARMGIGLGSE-----
----NAAGP--CNWD-------------EADIGPWA-KARIQSGAEAKAKVQESG--GAS
ASTTTST------NA----STSTGASA--SGGFTANNSLSATLTFGLFAGLGGAGASSSG
SSGACG-FSYK-------------------------------------------------
------------------------------------------------------------
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----------------------------------------------LDEKVISLV-----
-------NFMLFKYHMKEPVT-EADM---KVVIKEYE-----DHFTEIFLRACEH-----
----IEMVFGLD---------VKR-VDPTN---------HCYG-----------------
-------L----------------------------------FIKLGL-TYD----GV--
LD-GE-EGMPKTGIL-------IFILGVIFMKGNS------ATEE---EVWEVLNLT---
-----GIY-AGQ----KHAIFGEPRELITKDFVKE------KYLEYRQV-ANSDPAQFEF
----LWGPRAHAETT--KMKVLEFLAKVHGTDPS----S-FPSSYEE---ALQDEEESAR
LHM----A----------------------------------------------------
------------------------------------------------------------
------------------------V------LGF----------------WK---L----
------------------------------------------------------------
---------SEL---------------------NFQKL-SEL------------------
----------------NFLSVE------GNR---A------T------EEEICI--SQ--
------------------------------------------------------------
----KEV---QSNTIKEYEDHFTEIFLRACEHIEMVFGLDVKRVDPTNHCYG-LFIKLGL
TYDGVL-DGEEGM-PKTG---ILI----------FILGV----------IF--------M
-KGNS----A-T--EEEVWEVLNLTGIY--AGQKHAIFGEPRELITKDFVKEK-------
---------YLEYRQVANSDP---A--QFEFLWGPRAHAETTKMKVLEFLAKVHGT---D
------PSSFPSSYEEALQDEEESARARIS-AWSTSTSGAT-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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--------------------------------------MPRGQK---SKLRAREKR-RQN
-RA-----EAQGL-----------------------------------------------
-KS-------------AQAATAEG------------------------------------
-----------------------------------------------------------E
-AT--------------------------ASSPP-----V---------------TGDGA
SSSS-D-------------------------AGS----------------LQAPAS---V
S--AA-TSATAG------------------------------------------------
------------------------------------------------------------
-----------------VS----CKRSDVRG---------------KS-H-VQ-KSK---
-----------------------------KS--QAAHCSESSGQDLLTRKAGILA-----
-------NYLLCKYKMNEPIK-KGDML--KVIHKRYR-----EHFPEILKKASER-----
----MDLFFGLE---------VKE-VKPNS---------HSYS-----------------
-------L----------------------------------VCKLDD-TSE---GSV-S
----FAWQFPTKGIL-------MPLLGLIFLNGNR------ASEE---EIWELLNIL---
-----GVY-AGK----THFIFGEPRKLITQDLVQE------NYLEYRQV-PGSDPPRFEF
----LWGPRAQAETT--KAKVLDFLSKVKDTVST----D-FPPRYEE---ILRDEQERAR
AT-AATMAGAT-DK----------------------------------------------
----------------------------------------------------------AR
--------------------ARS--R-----------------------ATSS-RDPP--
-PE---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------QTEASM
EDSA-LLMQTLM-------EAIQ--IS-EAPPTNQA--TA--------------------
------------------------------------------AVSRLNASPPSSQPPSA-
K------------------------------------------------EMTD-------
------IHVVAAATRPKT------------------------------------------
-----------------------------AL---------------KAQ-----------
-------------NAT----------------TKGPNGAYDFSQAVNAKEMP-NTQPKAS
F-------------------KPQNATT--KGPNVAYD-------FSQAATT---------
---------NKSEMGFKAQNAT-TTVGPNA---------T-YNFSQSPNASEMTNSQTRT
------------------------------------------------------------
----------------------------------------------AFK-WNDTTKASTA
-------------------------------DTQT-----------QNT-----------
------------ATSQ--------ADIET--NPG---------ISEPEGA-AQASADGSQ
AQNLE--------------------S---------------------------------R
TIIRGKRTRKINNLNV---------EENSSGDQRWVPLTSGTWRSAPVPVTT-QNPPGAP
PNVLWQTPLA----WQNPS----GWQNQTARQTP----L-AHQSPPARQTLPTWQNPVAW
QNPVIWQNPVIWQNPVIWPNPI-VWPGPVVWPNPLAWQNPPGWQTSPGWQTPPSWQGTPD
WQG---PLDWPLPPDW-PLPP-DWPLP-TDWPLPHDWIPTDWPIPPDWQNLRPSPNLRP-
-SPNSRASQNLGASQ-PRDVALL---QERANKLVK------YLMLKD-YTKVPI--KR--
------------------------------------------------------------
----SEM---LRDIIREYTDVYPEIIERACFVLEKKFGIQLKEIDKEEHLYI-LISTPE-
SLAGIL-GTTKDT-PKLG---LLL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPLLGDLRKLLTYEFVKQK-------
---------YLDYRRVPNSNP---P--EYEFLWGLRSYHETSKMKVLRFIAEVQKR---D
------PRDWTAQFMEAADEALDALDAAAA--EAEAR----AEARTRMGIGDEAV-----
------SGP--WSWDDIEFELLT-WDEEGDFGDPWS-RIPF----TFWARYHQNARSRFP
QTFAS---------------------P--IIGPGGAPSA------NFAANFGAIGF----
--------FWVE------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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---------------------------------------MNRRNGYGYRTPALQ--A---
--------PLPPS--GSLGLP----------------------------FPLDVQTETKE
EDNV-LLMRSLL-------AATK--DP-----PVANRPKK-------------SKTKKTP
VKAI----------AKS-TSA--APAVPSATEI-ATKPKITLQALNLPIFAQISQGSAT-
I------------------------------------------------EAAN-------
------IQTSSGPAPPKKANKMKRITAKAALVSQCCPSGSEGVTAQLKSPLQAPNLPVIS
QTIQA---PVASELANSPAF-IASTKPKKTP---------------KSK-----------
-------------KAA----------------NKAVGSANEISLAI-----G-TTQGQIN
-NETANIQATAATIRTKKASKAKRTTA--KATNTDTE-------HLESLNA---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------TETAT
RQTET--------------------S---------------------------------A
AVLWPKKPKGKKVASKGP---------N------------SAFEVSEAPPATQMVTNQAL
VATLRVKRGS----RARKA----ATKVQVTESQT----QIADQGSPAKMATSQ-MSINAL
ETQ------------VA------------TAVQALADDYLAQL----SLEPTTRTRGKRN
RKS-----------------------------------------------KHLNGDERS-
SINYRRIPWGRRLSP-PRDVAIL---QERANKLVK------YLLVKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LKDVIQEYDEYFPEIIERASYALEKMFRVNLKEIDKQSSLYI-LISTQES
SAG-IL-GTTKDT-PKLG---LLM----------VILSV----------IF--------M
-NGNK----A-N--EAVIWEVLRKLGLH--PGVRHSLFGEVRKLITDEFVKQK-------
---------YLEYKRVPNSRP---P--EYEFFWGLRSYHETSKMKVLKFACKVQKK---D
------PKDWAAQYREAVEMEVQAAAVAVA--EAEAR----AEARAQMGIGEEAV-----
------AGP--WNWDDMDIDCLT-REELGDDTQAWN-RFSF----EIEARTQENADETTN
VNFNQEDSTRDSFSDGASISFNGAPSS--SGGFGGGGG----------------------
------------------------------------------------------------
---------------------------------------------------------ITF
GDAPSTSAGFSSVASISFGGTPSTSASFSSVASISFGSALNTSTSFTGGASINFGDTPST
SASFCSTASISFGGTPSTITSFSGGASISFDGAPSTSTSFSS----------------TA
SISFGGTPSTSTSFSGGASISFGGAPNISTNFSGGASISFDGAPN--SSTSFSGGASISF
GGTPCTSASFSAGASSSFGGTLNSITTGFSGALSSSTSFGSASTTSTVFSGALNTSTGFG
GTLSTSVCFGGSPISGSSFGGTLSTSICFGGCPSTSIGFGCASTSILSTSVSFGGSSSTS
SDFGGTLSTSVCFGGSPSTS-ANFDGALNSSAGFGGAISTSVGFGDAVNTSASFGS----
------------------------TLNSSAGFGSAISTGASFSGAFSSSAG---------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------FSSAINTSAGFDGAVSTCTGFGSALNSS
ASFGSVISTSASFGGALNSSSGFGSTLSTSAGFGNAHNTSASFDGVLNTSAGYGGAISTT
AGFSGAPSTNPGFGSAFSTSAGFSGALSITTNFGGTPSSNIGFDSAPSTSVSFDGAHSTS
LCFGGAPSTGLCFGSASNTNLCFGGSPSTSACFSGATSASFSDGPSTSAGFSFGNGLSTS
AGFGGGLSTSAGFGGSLSTSTGFGGSLGTSTSFDSGLGTSTDFSGGLSTSAGFGGGLSTS
AGFGGGLGTNADFGGGLGTVAGFGGRLGTGAGFGGGLGTSTGFGGGLVTTDGFGGGLGTS
AAFGSTLGTCSGFSGSLSTSDGFGSGPNASFDRGLSSIIGFGSGSNTSTGFPGEPSTGTS
FSSGPSSIVGFSGGPSTGAGFCSEPST-GGYGGGLSTGASFAGSSPGA-GFGVGLS----
------------------------------TSIGFSGGPSSSANFGGGLNTSAGFSGEP-
STSSGFGG----------G-PSTGDGFGGGATSLGACGFSYS

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------MPRGQK---SKLRAREKR-RQA
-RS-----ENQDP-----------------------------------------------
-KG-------------AEATAAEE------------------------------------
-----------------------------------------------------------G
-KSP-------------------------SSSSH-----V---------------SGKES
QSTS-A-------------------------AGI----------------LQGSQA---A
R--ST-S-----------------------------------------------------
------------------------------------------------------------
-----------------TS----RSSSGEGA---------------KI-Q-EK----G--
----------NP-----------------RS-TRAQAASRHPRKDPLTEKVDMLM-----
-------QLLLHKYKMKEPIL-KADML--SMISKKYK-----KHFPKVLQRITER-----
----MELVFGLD---------LKE-VSGSD---------PSYT-----------------
-------L----------------------------------VCKLEL-SSE----ECLD
----DGRGFPKTGLL-------LPLLGMIFMNDHR------VTEE---EMWAFLNVL---
-----GVF-DGR----QHFIFGEPRKLITKDLVEE------KYLEYQQV-PNSDPPRYEL
----LWGAKAHNEIN--KMKVLEFLARIKGTAPS----T-FQSRYEE---ALRDEENRSR
ARNA-AKG----------------------------------------------------
-----------------------------------------------------------G
--------------------ATTPP------------------------------GA---
------------------------------------------------------------
------------T-----------------------------------------------
------------------GARVQ---KSCQPSKQ--------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------

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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------MSLAQ-----------------
-----------------RSP-HRKPD-E----------------DLEA----QGE-DLG-
-------------LMGAQEPTGEE------------------------------------
-----------------------------------------------------------Q
E-T---------------------------------------------------------
------------------------------------------------------------
---TSSSDSE-----------EEE------------------------------------
---------VS--------------------------------------ASGS---SSPP
QSPQGGAS---SSFSVY-Y--TLWSQFDE----------------GSSS--QEEEEP---
------------S------PSVDPA------------QLEFMFQEALKLKVAELV-----
-------HFLLHKYRVKEPVT-KAEML--ESVIKNYK-----RYFPVIFGKASEF-----
----MQVIFGTD---------VKE-VDPAG---------HSYI-----------------
-------L----------------------------------VTALGL-SCD----SMLG
---DG-HSMPKAALL-------IIILGVILTKDNC------APEE---VIWEALSVM---
-----GVY-VGK----EHIFYGEPRKLLTQDWVQE------NYLEYRQV-PGSDPAHYEF
----LWGSKAHAETS--YEKVINYLVMLNAREPI----C-YPSLYEE---VLGEEQEGV-
------------------------------------------------------------
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------------------------------------------------------------
------------------------------M---------------GIAV-R--------
------------------QEW---------------RT---FFGSETAHERSKST-----
-------TKKKTTLHAHIHTH-CCDIL--KNIIKDYK-----GVYSEIIKRASRT-----
----LQQVFGLQ---------LVE-IDTKH---------HIYI-----------------
-------L----------------------------------VSNLPRLEGE-----DLK
----QDDSTAKLGLL-------TVILSFLFMKGNA------AKES---AVWEMLRRL---
-----RID-PGM----RHEVFGDVKKLVTEEFVRQ------KYLEYNRI-PHTDPPEFEF
----QWGARAAKETS--KMQILRFVAKIQSKDPE----A-WSTQYNE---AAAEVTATGG
LFQD-TRPL-GDTG--------GASQ----------------------------------
------------------------------------------------------------
GAR--RRN------RSAHSQPE----RPVS------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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--------------------------------------MADSH-----------------
-----------------NTQ-YCNLE-E----------------SAQA----QQE-----
-------------LDNDQET----------------------------------------
------------------------------------------------------------
--------------------------------------METS------------------
------------------------------------------------------------
---EEEE-DTTT----SNK--V--------------------------------------
----------Y--------------------------------------GSAI---PSPP
QSPQRAYS---PCVALA-S--IPDS------------------------P-SEEASI---
------------K------GSEGLE------------DPLHLLHNAQNTKVYDLV-----
-------DFLVLNYQMKAFTT-KAEML--ENIGREYE-----EYYPLIFSEASEC-----
----LKMVFGLD---------MVE-VDSSV---------HTYM-----------------
-------L----------------------------------VTALGI-TYD----GM--
MT-DV-QGMPKTGIL-------IAVLSVIFMKGNY------VSEE---IIWEMLNNI---
-----GLC-GGR----DPYIHKDPRKLISEEFVQE------GYLEYRQV-PNSDPPSYGF
----LWGPRAFAETS--KMKVLQFFASINKTHPR----A-YPEKYAE---ALQDEIDRTK
TWILNRCSNSS-------------------------------------------------
------------------------------------------------------------
-----------------------DL-------------------------HT---F----
------------------------------------------------------------
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--------------------------------------MSLEQ-----------------
-----------------RSL-HCKPE-E----------------ALEA----QQE-ALG-
-------------LVCVQA-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---AASSSSPLV----LGT--LEE------------------------------------
---------VP--------------------------------------TAGS---TDPP
QSPQGAST---FPTTIN-F--TRQRQPNE----------------GSSS--REEEGP---
------------S------TSRIL---------------ESLFRAVLTKKVADLV-----
-------SFLLLKYRAREPVT-KAEML--ESVIKDYK-----HCFPVIFGKASES-----
----LQLVFGID---------VKE-ADPTG---------HSYV-----------------
-------L----------------------------------VTCLGL-SYD----GLLG
---DN-QIMPKTGFL-------IIVLVMIAMEGGH------APEE---EIWEELSVM---
-----EVY-DGR----EHCAYGEPRKLLTQDLVQE------KYLEYRQV-PDSDPARYEF
----LWGPRALAETS--YVKVLEYVIKVSARVRF----F-FPSLREA---ALREEEEGV-
------------------------------------------------------------
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---------------------------------------MDSQSPLQRPQSPPEGEDSLS
PLYIPQ---CPPEGEDSLSSLQFPHSPPVRKASLSPLQIPPCPPDGEDSQSPLQT--PQS
-P--PEWEVSLSPLRFP---HSPPQG-E----------------DSQSSLQSPVI-ICS-
-------------SS---------------TSLS-----------------LPQ------
---SFPERPQRP-----------------------------------PEGPAQSP--LQK
P-----------------------------LRSF-SYTLASLLQSSH----------GSP
Q--------------------------------------------SPPEGPAQSPLQRPV
SSFSSTSL-SLS----QSS--PESP----EGPAQRPLQSRVSSSSSTSLSLSQSSP----
----ESPQSPS--------------------------------------EGPA---QSPL
QSAVSSFS--------S-S--TSLSPVSE----------------ESSSP-VDED-T---
------------S------TSDTLLESESLTDSESLIESEPLFTYTLDEKVDELV-----
-------RFLLLKYQAKQPVT-KAEMV--TNVINRYT-----GYFPMIFRKAREF-----
----IEILFGIS---------LRE-VDPE----------DSYV-----------------
-------F----------------------------------VNTLEL-SCE----GS--
VS-DE-QGVPQNHLL-------FLVLSIIFMKGTC------ASEE---VIWDVLSGI---
-----GVR-AGR----EHFIFGEPRELLTKVWVQE------HYLEYREV-PNTAPPRYEF
----LWGPRAHSEIS--KRKVVEFLAMLNNTVPI----S-FPPSYKE---ALKDVEERAQ
AIIDTTDDS-T-------------------------------------------------
------------------------------------------------------------
-----------------------AT------DSA----------------SSS--V----
------------------------------------------------------------
---------VSP---------------------SFSS-----------------------
------------------E-----------------------------------------
------------------------------------------------------------
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--------------------------------------MPRA-P----------------
-----------------KRQ-RYMLE-E----------------DLQA----QM------
------------------ATAVDE------------------------------------
-----------------------------------------------------------E
D-TS-----------------------SSSSTCSSSFPGSSS-S----------------
-----------------------------------------------------------T
----SSSCYPLL----SSS--PEE--DFG---------------------YDE-------
----------L--------------------------------------LSPS---QSPL
T--AS--S---SHTATT-S--TPCSQSD-------------------VSS-QGEEGP---
------------S------TSQSLT------------GSKSLSRSEIDEKVNDLV-----
-------EFLLLKYRMKELTT-EAEML--NSVIKNYQ-----EHFPVIFSEASEC-----
----MQLVFGID---------LKE-VDPSS---------HSYV-----------------
-------L----------------------------------VTTLGL-TYD----GMLS
---EV-QGMPKVGLL-------VLILSIIFMEGNC------ASEE---VVWEALSVM---
-----GVC-AGR----EHFIYGDPRKLITHDWVQE------EYLVYRQV-PNSDPAHYEF
----LWGPRAHNETS--KMSLLEFLAKVNGSDPR----A-FPVWYEE---ALRDEEEKAQ
------------------------------------------------------------
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--------------------------------------MPRGQK---SKLRAREKR-RET
-HG-----QPQGL-----------------------------------------------
-TG-------------PQVTGEKQ------------------------------------
-----------------------------------------------------------E
-ESR-----------------------SSSSSSA-----V---------------CRSAR
RRSS----------------------------DSS-------V-------PQESQG---A
S--PTGSPDAGVSCSKSDVAA----KGQDEKS------------PSTSRDASVSQESQ-G
ASPTGSPDAGISC---------SKS--------DVAAKGQDEKIPSTSPDTSL-----PQ
ESQGASPTG---FPDAGVS----GSKSDVAA---------------MGQ---EGESI---
-----------------------------SP-SERTVFLTTADRDPLNRKASKMV-----
-------QFLQKKFEKKESIL-KADML--RRVRRQYK-----PCFPEILKRTSER-----
----LAVAFGVE---------LKE-MDSSG---------ESYT-----------------
-------L----------------------------------VSKLGL-SSE----GSLS
----GDNALPKSGLL-------MSLLSLIFMKGNR------ATEE---EVWEFLGVL---
-----GIY-DGI----LHSIYGDTRKIITEDLVQD------KYVVYRQV-RNSDPPRYVF
----LWGPRAHAETT--KMKVLRVLAEINNTSPG----L-YPHLYED---ALIDEVERAL
RLRA--------------------------------------------------------
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---------------------------------------------------METQIRREG
LGCSPASIKRKKKKEDSG--HLGLQVSTMFSEDDFQST---EGAPSGPQI----------
---------QWSQDLPRVQVFRE----------QANQE---DRSPR-RTQRITGG-EV--
-----------------LWGPITQIFPTVWPADLTRVIMPLEQ-----------------
-----------------RSQ-HCKPE-E----------------GLQA----QED-NPG-
-------------LVGGAQALQAE------------------------------------
-----------------------------------------------------------E
Q-E---------------------------------------------------------
------------------------------------------------------------
---AASFSSTLN----VGT--LEE------------------------------------
---------VP--------------------------------------ATES---PSPP
QSPQGESS---SPTAMD-S--IFGSLSDE----------------GSSS--QEEEGP---
------------S------TSPDLI------------DPESFSQDILHDKIIDLV-----
-------HLLLRKYRVKGLIT-KAEML--GSVIKNYE-----DYFPEIFREASEC-----
----MQLLFGID---------VKE-VDPTS---------HSYV-----------------
-------L----------------------------------VTSLSL-SYD----GIQG
---DE-QSMPKSGLL-------IIVLGVIFMEGNC------VPEE---VMWEVLSIM---
-----GVY-AGR----EHFLFGEPKKLLTHDWVQE------KYLVYRHV-PGTDPACYEF
----LWGPRAHAETS--KMKVLEYIANANGRDPS----S-YPSLYED---ALREEEEGV-
------------------------------------------------------------
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------------------MEKPTS------------------------------------
-----------------------------------------------------------D
-EER----------------------------------------------------EETR
RSVP-P-------------------------E-E----------------EEEEEE---Q
E--------------------------------------------------AAAA-----
----AAAAAA----------------------------AAAAAGAGA----GA-----G-
-AG---------------------------A---------------GAGA-GAG------
------------------AGAGAGAGA--GA-GAASRNPLQRSQSRIEKKVCEVV-----
-------QYLLVKDQTKIPIK-RTDIV--NTIIKEYK-----EMTTEIINRAGQM-----
----LEQVFGIE---------LKE-IDDKA---------PAYV-----------------
-------L----------------------------------LNKLEPLEED----DTMR
----PKHDTAKMGLL-------MVILSLIFMKGNS------AREA---VVWDMLRKM---
-----RLN-PDK----KHPLFGDVKKLVTDEFVRQ------RYLEYNRI-PYTDPEEFEF
----LWGPRAFLETS--KMQVLRFVAKIQRRDPR----S-WAVQYNE---ALQDEAATAS
ASAA-SASASTASA--------SASASASASAS---------------------------
--------------------------A-------------------------------AS
GSG--SAS------ASASASASASASASALAEPDV---LAETD-----------------
----------------------------------------SESD-T-------------E
---------A------------------------EACASASAS-------------FLG-
------------------------------------------------------------
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------------------------------------------------------SPDV--
--CRAVCHPLPQPPNSTLRLSSFPA-LCDPPYPQILALSPVQSSYCTPPSPP-VPAEASV
EDST-LLMQTLM-------EAIQ--IS-EAPPTSQA--PA--------------------
------------------------------------------AACGLNSSPQSSQPPEA-
S------------------------------------------------EMAD-------
------NQVSAAAAKPKT------------------------------------------
-----------------------------AF---------------KAQ-----------
-------------NAT----------------TKDPNAAYDFSQAVNAKET----LPKAA
F-------------------MTQKATP--KGPNAAYD-------FSQAATT---------
----SELTANNSEMAFKTQNAT-TKVGPNA---------T-YNFSQSLNASEMANTQPKT
------------------------------------------------------------
----------------------------------------------AFKAWNDTTKATMA
-------------------------------DTQT-----------QNV-----------
----NQA---KMATSQ--------ADIEAD--PG---------TSESDGAAAQTSADGSQ
AQNLE--------------------S---------------------------------R
TIIRGKRTRKINNLNV---------EENSSGDQRRAPLASGTWRSAPIPVTT-QNPPGAP
PNVLWQTPLA----WQNPS----GWQNQPARQTP----P-ARQSPPARQNPPAWQNPVAW
QNPVIWPNPVIWQNPVIWPNPI-VWPGPVVWPNPLAWQNPPGWQTPPGWQTPPGWQGPTD
WQG---PPDWPLPPDW-PLPP-DWPLP-TDWPLPPDWIPTDWPVPPDWQNLRPSPNLRP-
-SPNSRASQNLGASQ-PRDVALL---QERANKLVK------YLMLKD-YTKVPI--KR--
------------------------------------------------------------
----SEM---LRDIIR-YTDVYPEIIERAXXXXXXXXXXXXXXXXXXXXXXX-XXXXXX-
XXXXXX-XXTKDT-PKLG---LLL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPLLGDLRKLLTYEFVKQR-------
---------YLDYRRVPNSNP---P--EYEFLWGLRSYHETSKMKVLRFIAEVQKR---D
------PRDWTAQFMEAADEALDALDAAAA--EAEAR----AEARTRMGIGDEAV-----
------SGP--WSWDDIEFELLT-WDEEGDFGDPWS-RIPF----TFWARYHQNARSRFP
QTFTG---------------------P--IIGPGGTATA------NFAANFGAIGF----
--------FWVE------------------------------------------------
------------------------------------------------------------
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--------------------------------------MPQGQK---SKRCAREKR-RHA
-RG-----ESQGP-----------------------------------------------
-GG-------------AQATAAEK------------------------------------
-----------------------------------------------------------E
-ESS-------------------------SSSLP-----V---------------CEGAP
LSSP-A-------------------------TGP----------------LQKSQR---A
R--TT-SSPDAT------------------------------------------------
------------------------------------------------------------
-----------------IS----SSSSDEGA---------------KS-Q----------
----------------------------------------SSHKDPLARKAGTLV-----
-------HFLLYKYKMKEPIT-EAEML--KVINKKYT-----EQFPEILKRTTER-----
----LELVFGLE---------LKE-VDPSS---------HSYE-----------------
-------F----------------------------------VSKVGL-PTK---GRL-S
----DGVGFPKNGLL-------MPLLGVIFMNDNR------ATEE---KMWEFLN-W---
-----GVY-AGR----RHLIFGEPRKLITQDLVQE------KYLEYRQV-PDSDPPRYEF
----LWGPRAHAETS--KMKVLEFLAKVSDTVPT----A-FLGRYEE---ALRDEEERAQ
AR-DETKAAPG-AP----------------------------------------------
----------------------------------------------------------AS
--------------------DC--------------------------------------
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--------------------------------------MPRPQ-----------------
-----------------KRR-RVMVE-D----------------L-EA----QSE-T---
------------------------------------------------------------
--------------------------------------------------------VLIG
EEDSSSSST-----------------------CSSSFPS---------------------
---SFS---------------------------------------S----------TSSY
ITQMSD-----------NP----EEN----------------------------------
---------IA--------------------------------------VSEA---LNPS
QSPQIACS---SLGMAS-S--SDSQSRED----------------SESKE-SSRS-S---
------------Q------AAWAGL------------CVAFLSKSEMDVKVNELV-----
-------NFLLFKYLMKEPVT-KAEML--SNAIGDYQ-----EHFHVIFTKASLY-----
----MQMVFGID---------IKV-VKPAS---------QTYI-----------------
-------L----------------------------------VTALEL-TYD----GM--
MP-GS-LGFPKTGLL-------VMVICIIFTEGNS------VSEE---KLWEMLSNV---
-----GLY-AGK----DHFIYGEPRKLIYENFVQE------GYLEFRWV-PGSDPARYEF
----LWGLRTLAETS--KMKVLEFLTNINGSDPR----S-YPSQYAE---ALREEKERA-
------------------------------------------------------------
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--------------------------------------------------MLQTPE---S
R--------------------------------------------------GLPVP----
-------QAE----------------------------GEKDGGHDGETRART-----A-
-SQE-------------------RPKEELGA---------------GREE-G--------
----------------AAEPALTRKGA--RA-LAAKALARRRACRRLNRTVAELV-----
-------QFLLVKDKKKSPIT-RSEMV--KYVIGDLK-----ALFPDIIARAAEH-----
----LRYVFGFE---------LKQ-FDRKH---------HTYI-----------------
-------L----------------------------------INKLKPLEEE----E---
EEEDLGGDGPRLGLL-------MMILGLIYMRGNR------AREA---QVWEMLHRL---
-----GMQ-PSK----YHFLFGYPKRLIMEDFVQQ------RYLSYRRV-PHTSPPEYEF
----SWGPRSNLEIS--KMKVLGFVAKLHKKEPQ----H-WPVQYRE---ALADEADRAR
AKAR-AEASMRARA--------SARA------G---------------------------
------------------------------------------------------------
-IH----L------W---------------------------------------------
------------------------------------------------------------
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--------------------------------------MPRGHK---SKARAREKR-RLV
-QD-----EAKGL-----------------------------------------------
-KD-------------AHAKAGEK------------------------------------
------------------------------------------------------------
-ESP-------------------------SCSNH-----E---------------SGDAV
ASTS-T-------------------------AGF----------------PQKSKS---R
G--EAP------------------------------------------------------
------------------------------------------------------------
----------TSPDINGGA----YRRSRKST---------------RG-P-REESTS---
------------------------------C-SRVPRFNANPQNDILTRKTGILM-----
-------QYLLCKYKMKQPAN-KGEMI--KVINRRFK-----EHLPEILKKASER-----
----IQLVFGLE---------VKE-IKPSG---------GYYT-----------------
-------L----------------------------------VSKLDP-SVG----NALT
----TSLPFPQNGLL-------MPLLGVIFLNGNR------ASEA---EIWEFLNIL---
-----GIY-DGK----VHIIFGEPRKLITRDLVKE------RYLVYQKE-AGSNPPSFEF
----LWGPRAYAETT--KMKILEFLAKVNETVPQ----A-FPTHYEE---ALRDQEERAQ
AEAI-GNP----------------------------------------------------
-----------------------------------------------------------D
--------------------TSAKD------------------------------KA---
------------------------------------------------------------
------------E-----------------------------------------------
------------------AKVTL---I-RLSLKSH------LL-TPL-AKIRPS--LK--
------------------------------------------------------------
----SHLAPL-ANIRPSLKSHLLT---------------------PL-AK----IRQSKV
VPVDFS-CSWRD------------------------------------------------
------------------------------------------------------------
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--------------------------------------MPRGQK---SKLRAREKR-QRT
-RA-----QTQDL-----------------------------------------------
-KV-------------GQATAAEK------------------------------------
-----------------------------------------------------------E
-ESP-------------------------SSSSS-----V---------------LGDTP
SSSL-A-------------------------LGI----------------PQKPQR---E
P--PTTPAAAA-------------------------------------------------
------------------------------------------------------------
-----------------MS----GTGPDEGE---------------ES-Q-DE-ENA---
-----------------------------SS-SQASASAESSLKDPLTRKTKMLV-----
-------QFLLYKYKMKEPTT-KAEML--KIISKKYK-----EHFPEIFRKVSQR-----
----TELVFGLA---------LKE-VNPTT---------HSYI-----------------
-------L----------------------------------VSMLGP-SND---GNE-S
----SAWSLPRNGLL-------MPLLSVIFLNGNC------AGEE---EIWEFLNML---
-----GIY-DGK----RHLIFGEPRKLITQDLVQE------KYLKYQQV-PNSDPPRYQF
----LWGPRAYAETS--KMKVLEFWP--------------------------RDEEERTG
AR-PRVAARRG-TTAV--------------------------------------------
--------------------------T--------------------------------S
--------------------AYS--R-----------------------ATSS-SSSHPM
------------------------------------------------------------
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------------------------------MPR---------------------------
----------------------GNKSK-------------------------------GR
--------------------SRAKRQ-QTRGGESQI--LQGAQPTVKEEETAP-PSL---
----------------------VQGDAPS-SP---EVGTPQESQ-E-------------P
---------ASYG---S-------------PELGAKGSDA--G------V---KGSVADA
EDRSAHFSKVAAAIQ-SARRDPL---TRKANVLIE------FMMEKF-K VKEPF--TQ--
------------------------------------------------------------
----ADM---LRVINKKYKVHFTEILRRISVRLELVFGLELKVVDPSSQSYM-LVGKLGL
STEGSL-SGSSGL-PKTG---LLM----------TLLGV----------IF--------M
-KGNH----A-T--EEEVWEFLKVVGIY--PGKSHVIFGEPQEFITKDLVEEN-------
---------YVVYQQVPGSEP---P--SYEFRWGPRAYAETTKMKVLEVIAKINNT---S
------PSFFTSMYEEAMIDEANRAARR--------------------------------
------------------------------------------------------------
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------------------------------------------------------------
-----------RQRG-----------------------------------------PGCP
SLSIPC---ANTP---C-L-LS-------L-----TTVMPRGQK---SKLRSRAKR-QQA
-RD-----ETQGL-----------------------------------------------
-RG-------------AQATAEEE------------------------------------
-----------------------------------------------------------V
-GS--------------------------PCSSP-----L---------------DEGAL
PSSP-A-------------------------AGI----------------SQVSQR---A
P--PSSSLGA-G------------------------------------------------
------------------------------------------------------------
-----------------DS----CKSSEAGA---------------QE-R-----MP---
-----------------------------GS-SQAAASPESSRRDPLTRKASLLV-----
-------QYLLEKYKTKEPIT-QADML--KVVNKKYK-----EYFPEILRRTSER-----
----VELVFGLE---------LKE-VDPNS---------HSYV-----------------
-------L----------------------------------ISKLGL-SSE---GSL-S
----GSRGLPKTGLL-------MTLLGVIFMKGNR------ATEA---EIWEFLNVL---
-----GIY-AGR----RHLIFGEPRKLITKDLVQE------KYLEYRQV-PGSDPPSFEF
----LWGPRAHAETS--KMKVLEVLAKINDTNPN----A-FPNLYEE---ALKDEEEKAG
EK-AVGRVGAP-TR----------------------------------------------
----------------------------------------------------------PR
--------------------AVS--K-----------------------VLPH-RPSHI-
------------------------------------------------------------
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---------------------------------------MAQKMDCGAGLLGFQSPDA--
--CRAVCHPLPKPPASTLPLSAFPT-LCDPPYSQLRDPPAVLSCYCTPLGASPAPAEASV
EDSA-LLMQTLM-------EAIQ--IS-EAPPTNQA--TT--------------------
------------------------------------------A-----ASPQSSQPPTA-
N------------------------------------------------EMAD-------
------IQVSAAAARPKS------------------------------------------
-----------------------------AF---------------KVQ-----------
-------------NAT----------------TKGPNGVYDFSQAHNAKDVP-NTQPKAA
F-------------------KSQNATP--KGPNAAYD-------FSQAATT---------
----GELAANKSEMAFKAQNAT-TKVGPNA---------T-YNFSQSLNANDLANSRPKT
------------------------------------------------------------
----------------------------------------------PFKAWNDTTKAPTA
-------------------------------DTQT-----------QNV-----------
----NQA---KMSTSQ--------ADIETD--PG---------ISEPDGATAQTSADGSQ
AQNLE--------------------S---------------------------------R
TIIRGKRTRKINNLNV---------EENSSGDQRRAPLAAGTWRSAPVPVTT-QNPPGAP
PNVLWQTPLA----WQNPS----GWQNQTARQTP----P-ARQSPPARQTPPAWQNPVAW
QNPVIWPNPVIWQNPVIWPNPI-VWPGPVVWPNPLAWQNPPGWQTPPGWQTPPGWQGPPD
WQG---PPDWPLPPDW-PLPP-DWPLP-TDWPLPPDWIPADWPIPPDWQNLRPSPNLRP-
-SPNSRASQNPGAAQ-PRDVALL---QERANKLVK------YLMLKD-YTKVPI--KR--
------------------------------------------------------------
----SEM---LRDIIREYTDVYPEIIERACFVLEKKFGIQLKEIDKEEHLYI-LISTPE-
SLAGIL-GTTKDT-PKLG---LLL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPLLGDLRKLLTYEFVKQK-------
---------YLDYRRVPNSNP---P--EYEFLWGLRSYHETSKMKVLRFIAEVQKR---D
------PRDWTAQFMEAADEALDALDAAAA--EAEAR----AEARTRMGIGDEAV-----
------SGP--WSWDDIEFELLT-WDEEGDFGDPWS-RIPF----TFWARYHQNARSRFP
QTFAG---------------------P--IIGPGGTASA------NFAANFGAIGF----
--------FWVE------------------------------------------------
------------------------------------------------------------
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--------------------------------------MPRGQK---SKVRAREKR-RLV
-QD-----EAQEL-----------------------------------------------
-KD-------------AQAKAGEK------------------------------------
-----------------------------------------------------------G
-ESP-------------------------SCSNQ-----D---------------SGDAV
ASTS-T-------------------------AGF----------------PQKSKS---Q
G--EAP------------------------------------------------------
------------------------------------------------------------
----------TTTARKGGA----CRRSRKST---------------RG-P-REESTS---
------------------------------C-TRVPRFSENPQNDLLTRKTGILM-----
-------QYLLCKYKMKQPAY-KGEML--KVINRRFK-----EQLPDILKKASER-----
----IQLVFGLE---------VKE-IKPNG---------GNYT-----------------
-------L----------------------------------VSKLDP-SVG----NALT
----TSLPFPQNGLL-------MPLLGVIFLNGNR------ASEA---EMWQFLNVL---
-----GIY-DGK----VHIIFGEPRKLITRDLVKE------KYLVYQKE-ANSDPPSFEF
----RWGPRAYAETT--KMKILEFLAKVNETVPQ----A-FPTHYEE---ALRDQEERAQ
AEAV-GSP----------------------------------------------------
-----------------------------------------------------------G
--------------------TSAKD------------------------------KA---
------------------------------------------------------------
------------E-----------------------------------------------
------------------AKVTL---V-DSS-------------------------CK--
------------------------------------------------------------
----DQAESKVTLVDPSCKDIAKSK-------VTL---------GSS-HK----------
------------------------------------------------------------
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---------------------------------------MAQKMDCGAGLLGFQA-----
--------------------------------------------------------EASV
EDST-LLMQTLM-------EAIQ--ISEAPPTSQAT--A---------------------
------------------------------------------AASGQNASPQCSQLPTA-
S------------------------------------------------EMAD-------
------VQVLAAAARPKT------------------------------------------
-----------------------------AF---------------KTQ-----------
-------------NAT----------------TKGPNDVYDFSQAHSAKEIS-NTQPKAP
F-------------------KPQNATP--KGPNAAYD-------FSQAAAT---------
----SELAASKSEVALFKAQDVTTKVGPNA---------T-SNFSRSPSANEMATNQPKT
------------------------------------------------------------
----------------------------------------------AFKAWNDTTEAPIA
-------------------------------DTQT-------H--SQNV-----------
----NRA---KLATSQ--------ADTETN--PS---------IFEPDGAAAQTSAEGSL
AQNLE--------------------S---------------------------------R
TIIRGKRTRKINNLNV---------EENSSGDQRRAPLAAGTWRAAPVPGTT-QNPPGAP
PNVLWQTPLA----WQNPS----GWQNQAARQTP----P-TRQNPPARQSPPSWQNPIAW
QNPVIWPNPVIWQNPVIWPNPI-VWPGPVVWPNPVAWQNLPGWHTPPGWQNTPGWHGPPD
WQG---PSDWPLPPDW-PLPP-DWPLS-TDWPLPPDWIPADWPIPPDWQNLRPSSNLRP-
-SPNSRASQNLAAPQ-PRDVALL---QERANKLVK------YLMLKD-YTKVPI--KR--
------------------------------------------------------------
----SEM---LRDIIREYTDVYPEIIERACFVLEKKFGIQLKEIDKEEHLYI-LISTPE-
SLAGIL-GTTKDT-PKLG---LLL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPLLGDLRKLLTYEFVKQK-------
---------YLDYRRVPNSNP---P--EYEFLWGLRSYHETSKMKVLRFIAEVQKR---D
------PRDWTAQFMEAADEALDALDAASA--EAEAR----AEARTRMGIGDEAV-----
------SGP--WSWDDIEFELLT-WDEEGDFGDPWS-RIPF----TFWARYHQNARSRFP
QTFAG---------------------P--IIGPSGTASA------NFTANFGAIGF----
--------FWVE------------------------------------------------
------------------------------------------------------------
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--------------------------------------MPRGQK---SKLRAREKR-RQN
-RA-----EAQGL-----------------------------------------------
-KS-------------AQAATAEE------------------------------------
------------------------------------------------------------
-EAT-------------------------ASSPP-----V---------------TGDGA
SSSS-V-------------------------AGS----------------LQAPAR---V
S--AAASAAA--------------------------------------------------
------------------------------------------------------------
----------------GVS----CRRSDVRA---------------KS-R-VQKSEN---
--------------------------------SQAAPSSESSGHDLLTRKAGMLM-----
-------HFLLCKYKMNEPIK-KGDML--KVIHKRYR-----EHFPEILKKASER-----
----MDLVFGLE---------LKE-VKPNG---------HSYS-----------------
-------L----------------------------------VCKLDD-SRD----ESTS
----NALRFPTKVIL-------MPLLGLIFLNGNR------ASEE---EIWELLNIL---
-----GVY-DEE----THCILGEPRDIITQNLVQE------KYLEYRQV-PGSDPPRFEF
----LWGPRAQAETT--KGKVLDFLCKVNDTFPT----D-FPPHYEE---LLRGEKERAR
ATAA-TMA----------------------------------------------------
-----------------------------------------------------------G
--------------------ATDKA------------------------------RA---
------------------------------------------------------------
------------R-----------------------------------------------
------------------SRATS---S-RDPPHE--------------------------
------------------------------------------------------------
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--------------------------------------MPRGQK---SKLRAREKR-QQA
-RS-----EAQHL-----------------------------------------------
-QD-------------AQASAVEE------------------------------------
-----------------------------------------------------------E
-EFP-------------------------FFPTP-----L---------------LGGNV
QSSP-A------------------------SGSDR-------K-------SQGSGR---A
P--ST--TSA-G------------------------------------------------
------------------------------------------------------------
-----------------AS----CTRSNDGA---------------KS-Q-D--EKP---
-----------------------------ST-SQALPSTEFSCRTPLDEKAILLV-----
-------QFLLHKYNLRESIT-KEDMI--KHVIKKYK-----KHFTVILKKASEL-----
----MVLAFGIE---------VKE-VNPTT---------HCYA-----------------
-------L----------------------------------VSKFQC-TSD----GRLR
----GEEIMPKTGLL-------MTILCVIFMKGNC------ATEE---DVWEVLNVM---
-----GIY-AGR----KHFIHGEPKKLITKDLVQE------RYLEYRQV-PNSDPPRYEF
----LWGPRAHAETS--KMKVLEFLANIHDTVPS----A-FPSWYEE---ALRDEEERAR
AR-FATMLRTS-AL----------------------------------------------
----------------------------------------------------------AS
--------------------VHS--G-----------------------ASGQGSFPHL-
------------------------------------------------------------
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--------------------------------------MPRGQK---SKHRAREKR-RQA
-RA-----ETQGL-----------------------------------------------
-HD--------------QATTSGG------------------------------------
-----------------------------------------------------------E
-ETT-------------------------SSSPP-----D---------------SESGP
SSSS-A-------------------------AGT----------------SKGPQG---A
Q--GTTSAASGAIRKRSGVGRA--------------------------------------
------------------------------------------------------------
--------ARSRS--------------GVGA---------------EG-Q-VQEGE----
-----------------------------NS-SQASAAAESSHTDLLTWKAEMLV-----
-------QYMLFKYNTRELIK-RSEML--KVVHRRYR-----EQFPEILSRASEH-----
----MEMVFGMV---------LKE-VRPN S---------HCYT-----------------
-------L----------------------------------VSNLDL-SDS----ES MR
----GDWGLPKNGLL-------MPLLGVIYLNGHR------TSEE---EIWKFLNIL---
-----GIF-DGR----SHFIFGDTRKLITEDLVRE------EYLEYNLV-PGSDPPRYEF
----LWGPKALTETC--KTKVLQFLTKVNDLVPD----A-LLPHYLE---ASREEVENTG
AGAAA-GTGPSASAS-----AD---PSSLAIP----------------------------
------------------------------------------------------------
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------------------------------MPR---------------------------
----------------------GKKSK-------------------------------LN
ARE--------------------RRH-RARNYAQA---SEGAEETVVATEESS-PKSCG-
--------------------------------------TS EMPE-K------------KS
---------VSTI---T-------------VDLFSLS--D-DS---------FIDL----
EDAEDLFRD--YHTI-S-HQDIL---TQKVFVLVQ------I LLKNY-KTKQLT--TI--
------------------------------------------------------------
----EDM---MQVIDEEEMDDFPEILRKAAERLADVFAVELREVESSRRVYD-LISKLKL
PNNGRV-RAGQGF-PKTG---FLM----------TVLGI----------IF--------M
-NGNC----A-D--EEDIWRTLRSMGIY--SGKKHQIYGEPRKLITQNFVKLK-------
---------YVECRQVANTNP---P--RYEFLWGPKAYAETNKMAILKFVAKVNEI---S
------PSYFKDLYKEALKDDQGKNQGNHN-VSSAIHPKD-RAFS----FVMCPRLAFSN
VEV---------------------------------------------------------
------------------------------------------------------------
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------------------------------MPR---------------------------
----------------------GNKSK---------------------------------
-SR-----------------SRAKRQ-QIRGEKPK---LQGAQPTVKEEGK------AA-
-SP-------------------ALD-QGD-APSSSDRGTAQESQ-E-------------A
---------ASHI---S-------------PELNVSHPVHDVG---------AEG SFAGV
DERRANVSIIADAIQ-CARRDPL---TRKASKVLH------YLLEKY-QKDEQP--VE--
------------------------------------------------------------
----GEM---L KLIGRKYKVHFPQILEKATYQLELVYGLELKVDNPATHSYV-LVSKLPI
LPGANV-GGRREL-PKTG---LIL----------TILGM----------IF--------M
-KGNR----A-T--EEEVWQFLHMQGIY--PGRRHLIFGEPRNFITKELVEQK-------
---------YVEYRQVPGSDP---P--TYEFLWGPRAHEESTYRKVMDILAKIKSA---I
------PNYYPQQYEETLSNQAERAARRDE-AGGFHAA---RIPS----HAQASSSSHI-
------------------------------------------------------------
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------------------------------MPR---------------------------
----------------------NHRNK-------------------------------HH
--------------------ARGKCH-QVEGDTQE---AQAS--AAAAPG-----EECP-
-SS---------------PSSAPQGSPPS-SP---AAGDHQELQ-G-------------A
---------VAPS---S-------------PVAEASWAGSEEG-------------AQGP
EEES ADAARAALLAR-SIRKDPL---TRKASM VMD------FLLERY-TKKEPI--TQ--
------------------------------------------------------------
----NSM---LRVISRKYKQHFPEILSRASERVELVFGLELKEVDSSRNIYT-IVNKFSL
RVEEGS-SDEEEL-PKSG---LLM----------ALLGI----------IF--------M
-KGNR----A-T--KEEIWDFLSVLGIY--AGKKHSIFGEPRKLITKDLVQKG-------
---------YLNYRQVPNSDP---P--GYKFLWGPRAYAETTKMKVLEVLAKIQDK---V
------PSSFPDLYDEALRDQVERAGLRGT-ARPPIMAEASAPTRAKSC------SSSCI
------------------------------------------------------------
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--------------------------------------MPRGQK---SKLRAREKR-QRT
-RA-----QTQDL-----------------------------------------------
-KV-------------GQATAAEK------------------------------------
-----------------------------------------------------------E
-ESP-------------------------SSSSS-----V---------------LGDTP
SSSL-A-------------------------LGI----------------PQKPQR---E
P--RTTPAAAAMSGTG--------------------------------------------
------------------------------------------------------------
--------------------------PDEGE---------------DS-Q-DEENA----
-----------------------------SS-SQASTSTERSLKDPLTRKTKMLV-----
-------QFLLYKYKMKEPTT-KAEML--KIISKKYK-----EHFPEIFRKVSQR-----
----TELVFGLA---------LKE-VNPTT---------HSYI-----------------
-------L----------------------------------VSMLGP-TND----GNQS
----SAWSLPRNGLL-------MPLLSVIFLNGNC------AGEE---EIWEFLNML---
-----GIY-DGK----RHLIFGEPRKLITQDLSLC------RNQQD-ES-PGV------F
----GQGE----------------------------------------------------
------------------------------------------------------------
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--------------------------------------------------------MAE-
----------------------------------------------------------GS
FS-----V-Q-------SENYSVEDMDEGSDEVG--EEEMVEGNDYE----EFGAFGGYG
TLTSFDIHI--LRAFGSLG-----------------------------PGLRILSNEPWE
LENP-VLAQTLV-------EALQ--LDPETLANETAARAA-------------NVARAAA
---S----------NRA-ARAA--------------------AAAARTAFSQV---VASH
R-------------------------------------------------VAT-------
------PQVSGEDTQPTTYAA--EAQ--------------------GPTPEPPLASPQTS
------QMLVTSKMAAPGAPAT-SAQSQTGS---------------PAQ-----------
-------------EAA----------------TEGPSSACAFSQAPCAREVD-ANRPSTA
FLGQ----------------------------NDVFD-------FTQPAGV---------
----SGMAFPRPKRPAPAQEA--ATEGPSA---------AS-GVPQTGPGREVAATRPKT
T-----------------------------K-----------------------------
------------------------------------------------------------
--------------------------------------------------------SGKA
LAKTRWVEPQNVVAAA--------AAKA-KMATS---------IPEPEGAAA--ATAQHS
AE-----------------------P---------------------------------W
ARMGGKRTKKSKHLDDEY--------ESSE-EERETPAVPPTWRASQPSLT---------
---------V----R---------------------------------------------
----------------------------------------AQLA----------------
-----------------PRPP-----------------------------M----A----
-PRSQIPSRHVLCLP-PRNVTLL---QERANKLVK------YLMIKD-YKKIPI--KR--
------------------------------------------------------------
----ADM---LKDVIREYDEHFPEIIERATYTLEKKFGIHLKEIDKEEHLYI-LVCTRDS
SAR-LL-GKTKDT-PRLS---LLL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPFLGDLRKLITDDFVKQKNPELREG
TPLSMAPSWYLEYKKIPNSNP---P--EYEFLWGLRARHETSKMRVLRFIAQNQNR---D
------PREWKAHFLEAVDDAFKTMDVDMA--EEHAR----AQMRAQMNIGDEAL-----
------IGR--WSWDDIQVELLT-WDEDGDFGDAWA-RIPF----AFWARYHQYILNSNR
ANRRA------TWRAGVSSGTNGGASTSVLDGPSTS-ST---IRTRNAARAG--------
----ASFFSWIQHR----------------------------------------------
------------------------------------------------------------
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MSVS-P-------------------------PGH----------------MLQKTR---S
R--------------------------------------------------SHPGA----
-------QLW----------------------------SPSDCCP---------------
--------GVSRE----------IARASGHP---------------DASQ-D--------
------------------TPGTPSPSF--RQ-VQATSAPELWTQKQLELKVAELV-----
-------QFLLIKDQRKIPIK-QSGIM--KHVVRDYK-----NIFPDLLKLAAER-----
----LHYVFGYK---------LVE-LDPKS---------NAYI-----------------
-------L----------------------------------INALEPVGKD----GELR
----GYQRTPTTGLL-------MIILGLILMNGHS------IPEN---DVWCFLRRL---
-----GVY-PTK----KHSVFGYPKKLITEDFVKQ------RYLEYRRI-PHTDPVDCEL
----QWGPRANLETS--KMKVLKFVAKIHNQDPK----D-WPTQYCE---ALADEQRRVR
PEPN-GPALTS-------------------------------------------------
------------------------------------------------------------
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---------------------------------------MAQKMDCGAGLLGFQS-----
--------------------------------------------------------EASV
EDSA-LLMQTLM-------EAIH--IS-EAPPTNPA--TA--------------------
------------------------------------------VASSQTASPQSLQPLTA-
N------------------------------------------------AVVD-------
------TEVSVAATRPKT------------------------------------------
-----------------------------AF---------------RAQ-----------
-------------NAT----------------TKGPNGVYDFSQTHNAKEMP-NTQPKAA
V-------------------KYHNTTL--RGPNTACD-------FSHAGST---------
----GELVTTKSELAFKAQKAT-TKVGPND---------N-YNLSPSPKANEIANNRPKT
------------------------------------------------------------
----------------------------------------------TFKVWNDTTKAPTA
-------------------------------DSQS-----------QNL-----------
----IDA---KMANSQ--------GDIETN--LG---------IYEPDGAAAQT-SDGSQ
AQNLE--------------------S---------------------------------R
TIIRGKRTRKINNLNV---------EEN-SGDQRQPPLAAGTWRSPPVPVTT-QNAPGVP
PHVLWQTPLA----WQNPS----GWQNQTARQNP----A-ARQSPVARQTPPAWQNPVAW
QNPVIWPSPVIWQNPVIWPNPI-VWPGPVVWPNPVPWQNPPGWQAPSGWQTPASWQGPPD
WPL---PPDW-------PLPP-DWSLP-TDWPIPPDWITPDWPIPPDWQNLRPSPNLRP-
-SPNSRASQNLGTPQ-PRDVALL---QERANKLVK------YLMLKD-YTKVPI--KR--
------------------------------------------------------------
----SEM---LRDIIREYTDVYPEIIERACFVLEKKFGIQLKEIDKEEHLYI-LISTPE-
SLAGIL-GTTKDT-PKLG---LLL----------VILGI----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPLLGDLRKLLTYEFVKQK-------
---------YLDYRRVPNSNP---P--EYEFLWGLRSYHETSKMKVLRFIAEVQKR---D
------PRDWTAQFMEAADEALDALDAAAA--EAEAR----AEARTRMGIGDEAV-----
------SGP--WSWDDIEFELLT-WDEEGDFGDPWS-RIPF----TFWARYHQNARSRFP
QTFTG---------------------P--IIGPGGTASA------NFAASFGAIGF----
--------FWVE------------------------------------------------
------------------------------------------------------------
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---------------------M-------SLVSKNACH----------------------
------------------------------------------------------------
------------------RSAETT------------------------------------
-----------------------------------------------------------A
-DY---------------------------------------------------------
-----------------------------------------------------------S
D--FHGEMQA----------------TDASGL------------P-A-------------
---------------------------------------------------SM------I
----------VPDAPQ----GPQAPVDPQVA---------------SASQ-AA-------
---------QDP----K--DLDV--LID-EQSRRLGA---LRVHDPLEDRSIALV-----
-------NFMRMKSQIEGSIQ--QTEM--LEFLREYS-----DQFPEILRRASAH-----
----LDRVFGLN---------LRV-LDPQA---------DTYN-----------------
----------------------L-------------------ISKRGL-QTN----DWIA
----ESLDMPKAGLL-------ALVLGHILLNGNR------ARET---SIWDLLLKA---
-----DVL---GEPQRINIPFGNTRNLLTTDFVRM------RFLEYWPV-YGTNPLEFEF
----LWGSRAHK--EITKM-----------------------------------------
------------------------------------------------------------
--------------------------E-------------------------------AL
K-----------------------F---VA----------------EAHDEEP-------
------------------------WSWPE-EYN------------KALEADKAKER---S
---------------------------------------------------------QA-
AG---L--------E-FWSED---TMNDKANDLVQ------LAINVT-EELLPI--HQ--
------------------------------------------------------------
----DEL---LAHTGKEFEDVFPNILSRATLILDLFYGFSLIEVDTSEHIYL-LVQQPES
EEEQMM-LESLGR-PTQE---YVM----------PILGL----------IF--------L
-MGNR----V-K--EANVWNLLRRFGVD--VGRKHAI--------TCKLMRQR-------
---------YLECRPLSYSNP---V--EYELLWGPRAHLETTKMKALEYMARLYRK---Q
------PQDWPEQYREAVE-----------DEEARARSEATAMFF----FGP--------
---M--------------------------------------------------------
------------------------------------------------------------
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------------------------------------------

-----------MRHG----N--THLLEAAFWVYSAGRNPLSSHVGILFSLEEK-------
-AQQLSDEKAHQLSEQRDMSQ--LSKNLGDSSPPAEAPKPP-------------------
----------VYSRPTVLMRAP-----PASSRAPPVPWDPPPIDLQA-SLAAWQAPQPAW
EAPQGQPPAPV---APMAQPPSLGAPMVQAPPLGGPMGKPPT------------------
---------------PGVLMIHP-PPPGAPIPQPPTPGVLMMHPSAPGAPMAHPPP-PGT
PMAHPP-------------------------PPGTPMAH---------------------
-----P---------P------------------PPG---------------------TP
------------------------MAHP--PPPGTPMVHPPPPGTPMAHPPPPGTPMAHP
PPPGTP--MA-------------------HPPPPGTPMAQP---PAPGVLMAQSLTPGVL
MVQPP-------------APGAPMAQPP---PPAALM-------------------AQPP
PPVAPMAKPPGPGVLMIHPAGSRAQITQPPATG---------------APMVQPAA----
---PPAQQMASWAPQAQPLILQIQSQVI----R-------APPQV---P-----------
-------Q---GPQAPPAQLATPPGWQATSPGWQAPPQGWQATPLGWQATQVTWQAPT--
----------IAWQAPPPV-RQGPPPIRP-------------GPPPIRPGPPPVR---QA
PPP---------------------------------------------------------
------------------------------------------------------------
--------IRQAPPLIRQAPP-PI------------------------------------
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--------------PAPQVLATPPPLWQALPPPP-----P---------------LRQAP
QARLPTPQLRAAPQVRAVPPIRAAPQVPTAPPAPQ-------MPTAPPAGPQAPQP---V
M--PAPLPAP----------------------------------------LSA-------
----------P-----------QAAH--CPPIIWQAPKGQAPVPHE--------------
------------------------------------------------------------
------------------------------------------------------------
---------MPSSMEFQEVQQ-AQ-AL--AWQAPKAP-----GHFWQPLPTQEAQRQ---
----APPLVQLE-------QPFQGAPASQKALQIQL-PTQQAQPS--GSQAELPSLQPQP
SWQGPPAALQGQPGAPLAGANFPMGSAKSLMTP-SGESRASSIDRRTSS-KE----RRTS
SKEKERRAPSKDRM----------IFGGTFCLPRA----LP---GALPTPWKNLPATSET
FTATPRVF-PST----SQFQPASSNAFKVPSSTSD----TPKSLPLAL---QDPFACIEA
LPAIPWVPQPNVNASKASRAVPTILM-ATAAAPK----A-MATT-QE---ASKTSDEPPR
RS-----------------------GKA--------------------------------
--TRK-----KKHLNTEE-EGSGQMLA-------------------------------MR
--H-WQAP----RHWESLD--LSDW--EVQTPVQ-V--LGDWEGPSTSRGLSGWEGPSTS
-RI---------------LSG---WEGPSTSWALSAWEGPSTSR-A--------------
---------LGLW---------------ESPVSPPSLIISELP-------------N---
LAQGFSATQDDPKLE-TQPLSPL---DERANALVQ------FLLVKD-QAKLPI--KR--
------------------------------------------------------------
----SEM---VRFIIREYKDECLEIISRASHKLECIFGYQLKEIDPKTHSYI-IVNKG--
QKGDSA-APYFDR-PKLG---LLM----------VVLSL----------IF--------M
-KGNC----V-R--QDLIFNFLYKLGLD--VRETHGLFGNTRKLITEVFVREK-------
---------YLEYRRIPFTEP---A--EYEFLWGPRAFLETSKMLVLKFLARLHKK---D
------PRCWPAQYYEALAECESEDLDEDE-PGP----GDNA-------DDP--------
---TSSPPPH--------------------------------------------------
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--------------------------------------MPRRQK---SKSHARRKR-HEV
-QG-----DTQEA-----------------------------------------------
-QA-------------SAAAAPKE------------------------------------
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-CP--------------------------SSHSS-----V---------------PQGSP
PSSP-A-------------------------AVD----------------GQELQG---A
M--APSSPDA-G------------------------------------------------
------------------------------------------------------------
-----------------PS----CAGSDEGA---------------QG-P-AE-ESS---
-----------------------------GA-SQAAPSTQSTRKDPLARKARKLV-----
-------EFLLEKYTEQEPIT-QNALM--KIVSRKYR-----QHFPEIFSTARER-----
----VELVFGLE---------MKE-IDRRG---------NIYT-----------------
-------L----------------------------------IRKLNL-RGN---DCR-R
----DEGALPKSRLL-------MVLLGVIFMNGNR------ATEE---EIWEFLSML---
-----GIY-AGR----RHCIFGEPRRLITKDLVQK------EYLNYRQV-PNSDLPRYEF
----LWGPRACAETS--KMKVLEVLAKFHGRVPS----S-FPDLYDE---ALRDQVERAG
R-----------------------------------------------------------
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--------------------------------------MPRGQK---SKLRAREKR-RQA
-RC-----ETQAL-----------------------------------------------
-KE-------------AQATAAA-------------------------------------
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AGES-------------------------PSACA-----L---------------SGGRP
A--------------------------------AA-------A-------PRRPQG---A
A--SFTGADA-A------------------------------------------------
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-----------------LS----GTDSDEGA---------------RS-Q-DE-GSP---
------------------------------R-S--SKGSEVSHRDPLNKKVVLLV-----
-------QFLLQKYQKREPIS-KADML--KFAVKKYR-----HQFNEILKRASEH-----
----MELAFGLD---------LKE-VDPIR---------HCYT-----------------
-------L----------------------------------VNKLDL-T-D----GSMH
----EDENMPKTGLL-------MIVLGVIFMKGNC------APEE---EVWEVLNMM---
-----GVY-AER----KHFIYGEPKKVITQDLVQL------QYLQYRQV-ANSDPPRFEF
----LWGQRAYAETS--KMRVLEFLAKIHDTVPS----A-FPSWYEE---ALRDEEERAR
AR-AAARARTA-AM----------------------------------------------
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--------------------------------------MSQNQK---SPCG------TPE
-HH-----SCSEI-----------------------------------------------
-QV-------------FKAM---E------------------------------------
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-SCP-------------------------SSSYS-----L---------------MPGSL
KDAP-A------------------------AETPS-------T-------SEGPQS---T
C--LSSVVPT-T------------------------------------------------
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-----------------IL----LSDSSESS---------------SS-H----------
--------------------------------DEDSVSLSEMRVDPLDGKVALLV-----
-------QFLLQKYKMKEPIT-KADML--DTVIKECK-----DDFLEILKRTSEG-----
----MELVFGVD---------VKE-VDPTS---------HSYA-----------------
-------L----------------------------------VNKLGL-TFD----ARLS
----SDESVPKTSLL-------IIVLGVIFMKGNR------ATEE---EIWEVLKML---
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AR-IVTEA----------------------------------------------------
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--------------------------------------MPRGHK---SKLRAREKR-RQA
-HG-----DTHSV-----------------------------------------------
-QG-------------AQATAAEE------------------------------------
-----------------------------------------------------------E
-GSP-------------------------SSSSP-----P---------------FGGPP
QSSP-A-------------------------AHT----------------PQRSQR---A
P--STTTPA-AG------------------------------------------------
------------------------------------------------------------
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-----------------------------SS-SSARAPSERPHRDPLTRRVTMLS-----
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----IELVFGLD---------LKE-ADSKG---------QCYV-----------------
-------L----------------------------------VSKLEI-TKE---ESL-S
----GGREFPKTGLL-------MPLLAMIYRNGNR------ATEE---EMWKFLNVF---
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GR-EWAGAGPH-AR----------------------------------------------
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---------------------------------------MSDT-----------------
---------------SE-SGA----------------------------GSACFQTKASE
KDSG-SVMQTLL-------IVTQ--NLEVSETPKAS------------------KA----
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--------QEISEAAKIS-------KALGVS---------------KAM-----------
-------------KV---------------------------SKAPEAQEAP-TIQSSPT
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--------------------------------------------------------VA--
-------------------------------DMKV-------------------------
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RLKVK--------------------A---------------------------------K
KARKVKHLEGEEDGS---------------SDQSQTSGTTGGRRVSKALMASMAKRASRG
PIAFWARRAS----RTRLA----A------------------------------------
------------------------------------WARRALL----SLRSPKARRGKAR
RRA---------------------------------------------------------
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TDAGIL-GTTKDS-PKLG---LLM----------VLLSI----------IF--------M
-NGNR----S-S--EAVIWEVLRKLGLR--PGIHHSLFGDVKKLITDEFVKQK-------
---------YLDYARVPNSNP---P--EYEFFWGLRSYYETSKMKVLKFACKVQKK---D
------PKEWAAQYREAMEADLKAAAEAAA--EAKSR----AEIRAQMGIGHGSE-----
----NAAGP--CNWD-------------EADIGPWA-KARIQTGAEDKAKAQESG--GAS
TS--AST------G----TSTSAGASA--SGGFSASASLTATLTFGLFTGLGGSGASTSG
NSGACG-FSYK-------------------------------------------------
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--------------------------------------MSMEQNN---------------
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-------------LVDAQLSGAEE------------------------------------
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TSSSFSSSS------SS---SSSSSSSSSFSSSSSSFSCCSSSSSS---SSFSSTSTSSS
TPSSSS------------------------------------------------------
-SSPSSSCSALF----LIP--MEEG-----------------------------------
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QGSQSADA---SPSSGE-A--TAWSQPRH----------------GS-SI-PDEQGS---
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-------VFLLFKYCTKQPTN-KAEML--EIVSKEYQ-----DDFPIILGQASEC-----
----MRLVFGID---------VKE-VDSSE---------HSYV-----------------
-------L----------------------------------ITILGL-SCD----GMLS
-G--E-RGLPKTSLL-------VLLLGVILLEDGC------APEE---EVWEALRVM---
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---MQCPSFSAF-------------------------------------KARIAAGSCGV
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--------------------------------------MSRY------------------
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EAGE------------A-IADIASIIFPSSNVSLPSFTPS-------------------S
---PSS---------------------------------------S-------S------
--SSSSSFLSLI----QSN--LGGNV----------------------------------
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QNAQSFFP---SS--------ALGGNLNE----------------ATSYQ-EAS--L---
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-HG-----QPQGL-----------------------------------------------
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ESQGASPTG---FPDAGVS----GSKYDVAA---------------KGQ---DEESV---
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EAPEGQLPAPV---PQLAQPPALGAPMVQAPQLGGAMAKPPT------------------
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PMTHPP-------------------------PPGTPMAH---------------------
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PQPGTSLPLP-------------------HAPIPVAPMAQQ---PTPGVLMAQQLTPGVL
MVQPP-------------AQGAPMIQHP---PAALMS-------------------Q-HP
ASITPMGKHPGPGVMMIHPPGARAPIIQPPVSG---------------APMAQPVLP---
----PAQPLVSWSPQGQPLILQIQSQVI----R-------TPQQV---P-----------
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-QEHPVPQELPVPLEIQEAQQ-AQ-----------AP-----THYWQPEPAQEAQEQ---
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QQ------QQQQQQQPQAPTNFPRGPTRSHMTPPSGEPGPSSLEPRGPP-RD----RRTS
GR--GRKGPPKERM----------IIGATFSAPRG----ASASRAYLPAAWANVSGPSET
LTATSGVF-PST----SHFQPASSNAFRGPSATSE----SPKSLPLPL---QDPYACVEA
LPAVPWVPYADANASSACNAVPTILM-VTATAPQ----A-SAPG-AE---ASKT-AEPPR
RS-----------------------GKA--------------------------------
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DCD-WRGP----RPCENPR--QSDW--EVQRAMQ-L--LGDQESLYTPQGRNDWACPNNS
-RV---------------PRG---FDGP------------STSQ-D--------------
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ISWGPSAALEDPNGE-SQPLSPL---DERANALVQ------FLLVKD-QAKVPV--QL--
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PEYNEL-TTHLDR-PKFN---LLM----------VVLSL----------IF--------M
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---------YLEYRQIPFTEP---A--EYELLWGPRAFLETNRMHILRFLSELYDN---Q
------AQTWTCQYLESLSELEYRDIN-----EETTDSDDDS-------YGP--------
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V-DS-----------------------SSSSTCSSSFPSSFSSS----------------
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HSPPGACS---SCTAMI-S--SPCSQFS-------------------AAS-EPEEGS---
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---DV-QGIPKTGLL-------IMVLSIIFMEGNC------ISED---MVWGVLNNI---
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--------------------------------------MPRGQK---SKLRAREKR-QET
-HG-----QPQGL-----------------------------------------------
-TG-------------PQVTAEKQ------------------------------------
-----------------------------------------------------------E
-ESH-----------------------SSSSSSH-----D---------------CLGTR
RRSS----------------------------DAS-------V-------PQESQG---V
S--PTGSPDAVVSCLKSDVAA----KGQDEKS------------ASTSPKASIPQESQ-G
VSPTGSPDAGISC---------SKS--------DVAAKGQDEKSASTSLEASI-----PQ
ESQGASPTG---SPDAGIS----GSKYDVAA---------------KGQ---DEESV---
-----------------------------RA-SQKAIIFKRLSQDPLKRKACALV-----
-------QLLQEKFEKKESIL-KADML--KRVGKRYK-----HYFPEILNRTSER-----
----LAVAFGVE---------LKE-MDSSG---------ESYT-----------------
-------L----------------------------------VSKLGL-SSE----GILN
----DAKGLRKSGLL-------MSVLGVIFMKGNR------ATEE---EVWEFLSCL---
-----GIY-AGM----THPIYGDPQKLITEDLVQD------KYVVYRQV-RNSDPPRYEF
----LWGPRAHAETT--KMKVLRVLAKSNNTSPG----L-YPHLYED---ALMDEVERAL
RLRA--------------------------------------------------------
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--------------------------------------MSHF-P----------------
-----------------KCP-RYMFE-Q----------------DLEA----ESE-THD-
-------------LIDAQVAVAEE------------------------------------
-----------------------------------------------------------E
E--------------------------VSSSPISFHF--SYLSS----------------
-----------------------------------------------------------S
-----PPSSPLL----PET--PEEVEM---------------------------------
------PTDVI--------------------------------------PSSP-------
QSPEITSS---HSSSSFST--IL-RTSDE----------------SSNTE-VEDEST---
------------S------TSQDTI------------DTVSLSKDPIEKKVTDLV-----
-------KFLLLKYRLRLPVT-KKEML--KVVKKRYK-----IQFPIIFRKACKC-----
----MEVVCGID---------MKE-VDPTT---------HSYI-----------------
-------F----------------------------------VNSLNL-TCD----EMVS
---GD-QGIPKNGLL-------IIILGVIFMEGNS------ASEE---EIWDLLNMM---
-----GVY-EGK----EHFIYGEPRKLITQDLVKK------KYLEYRQV-PGSDPARYEF
----LWGPKALVEIS--KMKVLEFFAKVNGTHPR----S-FSTWYEK---ALKDEEERA-
------------------------------------------------------------
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---------------------------------------MSDT-----------------
---------------SE-SGA----------------------------GVTRFQAEASE
RDSG-LTMQTLL-------TVTQ--NLEVSETLKTS------------------KA----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------PEVSEDVKVS-------KATGVS---------------KAT-----------
-------------EV---------------------------SKTPEAQEAA-ATQASAT
-TQLTDTQVLTA----EK--KSPTADT--KKPNADPQ-------AVTMPAT---------
----ETKK-----VTC--------------------------------------------
------------------------------------------------------------
--------------------------------------------------------VA--
-------------------------------DTKV-------------------------
----N-A--KATETEV--------AASKAPADEP---------EP--EGAAAQAQENQDT
RPKVK--------------------A---------------------------------K
KARKVKHLDGEEDGS---------------SDQSQASGTTGGRRVSKALMASMARRASRG
PIALWARRAS----RTRLA----A------------------------------------
------------------------------------WARRALL----SLRSPKARRGKAR
RRA---------------------------------------------------------
-AKLQS-SQEPEAPP-PRDVALL---QGRANDLVK------YLLAKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LKDIIKEYTDVYPEIIERAGYSLEKVFGIQLKEIDKNDHLYI-LLSTLEP
TDAGIL-GTTKDS-PKLG---LLM----------VLLSI----------IF--------M
-NGNR----S-S--EAVIWEVLRKLGLR--PGIHHSLFGDVKKLVTDEFVKQK-------
---------YLDYARVPNSNP---P--EYEFFWGLRSYYETSKMKVLKFACKVQKK---D
------PKEWAAQYREAMEADLKAAAEAAA--EAKAR----AEIRAQMGIGLGSE-----
----NAAGP--CNWD-------------EADIGPWA-KARIQAGAEAKAKAQESG--GAS
TGASTST------S------T--SASA--SSGFSASASLTATLTFGLFAGLSGAGASTGG
SSGACG-FSYK-------------------------------------------------
------------------------------------------------------------
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--------------------------------------------------------MAE-
----------------------------------------------------------GS
FS-----V-Q-------SESYSVEDMDEGSDEVR--EEEMVEGNDYE----EFGAFGGYG
TLTSFDIHI--LRAFGSLG-----------------------------PGLRILSVRPPA
--------------------GLG--LSPEGCVGKDCPASP-------------NLSSPAR
---K----------KRI-WEG-----------------------------------LGMF
R-------------------------------------------------ADC-------
------WEEAGQHRQANT------------------------------------------
-------------SVSPGNWKX--------------------------------------
-----------------------------------XXXXXXXXXXXXXXXXVDTTRPSTA
FLGQ----------------------------NDVFD-------FTQPAGV---------
----SGMAFPRPKRPAPAQEA--ATEGSSA---------AS-GVPQTGPGREVAATRPKT
T-----------------------------K-----------------------------
------------------------------------------------------------
--------------------------------------------------------SGKA
LAKTRWVEPQNVVAAA--------AAKA-KMATS---------IPEPEGAAA--ATAQHS
AE-----------------------P---------------------------------W
ARMGGKRTKKSKHLDDEY--------ESSE-EEREPPAVPPTWRASQPSLT---------
---------V----R---------------------------------------------
----------------------------------------AQLA----------------
-----------------PRRP-----------------------------V----A----
-PRSQIPSRHVLCLP-PRNVTLL---QERANKLVK------YLMIKD-YKKIPI--KR--
------------------------------------------------------------
----ADM---LKDVIREYDEHFPEIIERATYTLEKKFGIHLKEIDKEEHLYI-LVCTRDS
SAR-LL-GKTKDT-PRLS---LLL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPFLGDLRKLITDDFLTATL------
---TRASLVYLEYKKIPNSNP---P--EYEFLWGLRARHETSKMRVLRFIAQNQNR---D
------PREWKAHFLEAVDDAFKTMDVDMA--EEHAR----AQMRAQMNIGDEAL-----
------IGR--WSWDDIQVELLT-WDEDGDFGDAWA-RIPF----AFWARYHQYILNSNR
ANRRA------TWRAGVSSGTNGGASTSVLDGPSTS-ST---IRTRNAARAG--------
----ASFFSWIQHR----------------------------------------------
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--------------------------------------MEPTE-----------------
-----------------NNQ-SFNLW-D----------------IPQA----QME-ERG-
-------------PGSAQDP----------------------------------------
------------------------------------------------------------
--------------------------------------IAEA------------------
------------------------------------------------------------
---GEVEAIATA----PGD--V--------------------------------------
----------P--------------------------------------AGGT---PSSP
QSAQRAPS---PPTAMG-S--IS-----------------------------GASFG---
------------D------PLAGVP------------GTEFPSQDGLNGKIIDLV-----
-------RFLLVKFRRMELTN-KEEMI--VKTMRDYE-----EHYSVIFSKAAEC-----
----MKLIFGVD---------MLE-VDPFV---------HSYF-----------------
-------L----------------------------------HPALGI-TYD----GM--
LH-GV-IGVPKTGLV-------IIVLCVIFIENNC------VSEE---AFWYAMNIL---
-----GMQ-AGM----DHFIFGDPKSLITENFVEE------GYVEYRQV-PNSSPPRFEF
----LWGPRAYAETT--KMKILEFYASIVRQDPR----S-YPEKYAE---ALREEQERA-
------------------------------------------------------------
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---MGT---EAQPVVKAVILHCLPSCPHSCLLPPTRVIMSQD-Q----------------
-----------------ESP-RCTHD-Q----------------HLQT----FSE-TQS-
-------------LEVAQVSKALE------------------------------------
-----------------------------------------------------------K
S-----------------------------------------------------------
------------------------------------------------------------
---FLSSSHPLV----PGE--VKEA---P---------------------AAK-------
----------A--------------------------------------ESPL-------
DVPQSFCS---SSIAVT-T--TSSSESDE----------------ASSNQ-EEEDSP---
------------S------SSEDTS------------DPRNVPADALDQKVAFLV-----
-------NFMLHKYQMKKPIT-KADML--KIIIEDDE-----SHFSEILLRASER-----
----LEMIFGLD---------VVE-VDPTT---------HCYG-----------------
-------L----------------------------------FIKLGL-SYD----GMLS
---GE-KGVPRTGLL-------ILVLGVIFMKGNR------ATEE---EVWEVLNLT---
-----GVY-SGK----KHFIFGEPRELITKDFVKE------KYLEYQQV-ANSDPARYEF
----LWGPRAKAETS--KMKVLEFVAKVHGSYPH----S-FPSQYAE---ALKEEEERAR
ARI---------------------------------------------------------
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----VAQTNAQRR-----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------ENP----PSSPASG-------
------------------------DSHPG--FL------------LMHQKPCEAVPPSRD
---------VTD----------------------VLCAKAAKG-------------AQS-
QH---VGRPNAPKST-PSAEK---SQRDPLTRRVSLLLQ--FLLLKY-KMKEPI--TK--
------------------------------------------------------------
----AKE---M-KIITKRYKQFSEVLRRASEHMELVFGLELKAVNSNSQTYA-LVSQLEV
SKEEIL-IGKCGF-PKSG---LLV----------PLLGM----------LY--------M
N--------D-N--REEMWEFLNEFI------ALHFIFGDTRKLLTEDLVQEK-------
---------YLEYQQVPKSDP------PYEFLWGARAHTKACKKKVMEYFEKIKFI---N
------ITTFQDMYEETGEV------QERARGQSNVKAKVNARHV----KGR--------
---FSRSS-----HST--------------------------------------------
------------------------------------------------------------
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---------------------------------------MAQKMDCGAGLLGFQSPDA--
--CRAVCHPLPQPPASTLPLSAFPT-LCDPPYSQLRDPPAVLSCYCTPLGASPAPAEASV
EDSA-LLMQTLM-------EAIQ--IS-EAPPTNQA--TA--------------------
------------------------------------------A-----ASPQSSQPPTA-
N------------------------------------------------EMAD-------
------IQVSAAAARPKS------------------------------------------
-----------------------------AF---------------KVQ-----------
-------------NAT----------------TKGPNGVYDFSQAHNAKDVP-NTQPKAA
F-------------------KSQNATP--KGPNAAYD-------FSQAATT---------
----GELAANKSEMAFKAQNAA-TKVGPNA---------T-YNFSHSLNANDLANSRPKT
------------------------------------------------------------
----------------------------------------------PFKAWNDTTKAPTA
-------------------------------DTQT-----------QNV-----------
----NQA---KMSTSQ--------ADIETD--PG---------ISEPDGATAQTSADGSQ
AQNLE--------------------S---------------------------------R
TIIRGKRTRKINNLNV---------EENSSGDQRRAPLAAGTWRSAPVPVTT-QNPPGAP
PNVLWQTPLA----WQNPS----GWQNQTARQTP----P-ARQSPPARQTPPAWQNPVAW
QNPVIWPNPVIWQNPVIWPNPI-VWPGPVVWPNPLAWQNPPGWQTPPGWQTPPGWQGPPD
WQG---PPDWPLPPDW-PLPP-DWPLP-TDWPLPPDWIPADWPIPPDWQNLRPSPNLRP-
-SPNSRASQNPGAAQ-PRDVALL---QERANKLVK------YLMLKD-YTKVPI--KR--
------------------------------------------------------------
----SEM---LRDIIREYTDVYPEIIERACFVLEKKFGIQLKEIDKEEHLYI-LISTPE-
SLAGIL-GTTKDT-PKLG---LLL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPLLGDLRKLLTYEFVKQK-------
---------YLDYRRVPNSNP---P--EYEFLWGLRSYHETSKMKVLRFIAEVQKR---D
------PRDWTAQFMEAADEALDALDAAAA--EAEAR----AEARTRMGIGDEAV-----
------SGP--WSWDDIEFELLT-WDEEGDFGDPWS-RIPF----TFWARYHQNARSRFP
QTFAG---------------------P--IIGPGGTASA------NFAANFGAIGF----
--------FWVE------------------------------------------------
------------------------------------------------------------
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------------------------------------------

------------------------------------------------------------
------------------MSQ--LSTNLGDSSPPE-SPVPP-------------------
----------VHSRPTVLMRAP-----PASSRAPPVPWDPPPVDLQA-PLASWQAPQAAW
EAPEGQLP-------------------------------PPT------------------
---------------PGVLMVHP-PPPGAPMAQPSTPGVLMLHPSVPGAPLAHPPP-PGS
QMTHPP---------------P---------PPGTPMAH---------------------
-----PLPGTPMAHPPPPPPPPPP--PPPPPPPPPPGTPM----A-------HPPPPGTP
------------------------MAHP--PPPGTPMAHPLPPGNPMVHPLSPGTPMVHP
PPPGTS--MP-------------------HAPIPGTAIAQQ---PTPGVLMAQQLTPGVL
MVQPP-------------APGAQMVQPA---PPAALM-------------------TQPS
PSITTMAKPPGPGVVMIHSPGSRAPVIQPPVSG---------------APMAQPVLP---
----PGQPLTS-----------------------------APQQV---P-----------
-------P---APSTPQVQLGTGPSWQATTPNWQVTPQGWQGTPLNWQGTQVSLQAPA--
----------IAWQAP-PM-RQGFPPIRP-------------GPAPIRPGAPA-------
------------------------------------------------ILRQMPPVIRQA
-PS---------L-----------------------------------------------
--------MRQIPPLIRQAPL-PI------------------------------------
-----------------------------------------------------------R
--------------QATHGIASQTHLWQ--------------------------------
------------------------------------------IHLVPQAGLQVPQT---L
F--PASLSIT----------------------------------------IPVP------
-------QAVPQSGP-------RGMH--CPTIIWQAPKGQPPAPQEL----QV---PQEL
QVPQELQVPEELQVPEEVP----VPEEAPVP---------------EEVP-VPEEAP---
----------VPEEAPVPEEVPVPEE------VPVPEEVPVPEEVPVPQQLPVPQEVQVP
-QEVPEPQEVPGSFEFQEVQQ-AR-AM--GWQARKAP-----THFWQPAPAREAQEQ---
----ATPLTH-------QQQPFRGVPSSHRTRQTRR-PTHQAQAT--GLQAELPSVQPQP
SWQGPPPTAQAQPGASRAPTNFPRGPTRSHMT-PSGEPGPSSLEPRGPP-RD----RRSS
AR--DRKGPPKDRM----------IIGATFCAPRA----ASASRAYLPTAWRNLPATSEN
LAATARVF-PPT----SHFQAASSNAFRGPSATSE----SPKSLPFAL---QDPYACVEA
LPAVPWVPFPEVNASSACKAVPAILM-VTAAAPQ----A-SATI-PE---ASKS-AEPPR
RS-----------------------GKA--------------------------------
--TRK-----KKHLEPKE-EDCGHRMT-------------------------------SR
--D-WRGP----RPCEGTR--QNDW--EIQRAMQ-L--LGDRDSFYTPQGMNGLGSPHKI
-RG---------------------------------------------------------
-----------SV---------------VNQGGSQPWAVSEVP-------------S---
VSWGSR--------A-SQPLSPL---DERADALVQ------FLLAKD-QAKVPV--QL--
------------------------------------------------------------
----SEM---VNV--------SLDIISGANAKLECTFGCQLREVDTKTHSYI-IVRKTGL
PP------FYLDR-PKFN---LLM----------VVLSP----------IF--------M
-KGCC----I-R--ENPLFNFLSQLELD--VHETSGLVRSMRKLTTRVFVKRR-------
---------YLEHRQVPFTES---A--EYELLWGPRAFLETNQVHVLRFSAALDAN---Q
------AQTWTSQDLESLTALEYKDTY-----ETSHDSDDDT-------PNP--------
---TSSPHPH--------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
---------------------------------------MDRRNDHGHRVPTFQ--G---
--------PLPPA--GSLGLP----------------------------FSPDVQSETTE
KDP-----------------------------PIASRSKK-------------NKNKKNS
IKPM----------DKT-TPA--PPPVPSANDNASNKPKVTLQALNLPMFTQISQASAT-
T------------------------------------------------EAPN-------
------IQASVTSQTQK--AKTMRVTP------KVSLTGSEDATTQLKPPLQALNLPVTT
PTIQT---PVANESANSLAS-TAVNKSKKAS---------------TAN-----------
-------------NAA----------------NKTVPSAAEISLASAATHTV-TTQGQAA
-KETGSIQTIAATARSKKNSKGKRTPA--KTTNTDNE-------YVEASNA---------
----IEAS--SRQIGASGRQTE------AS---------N-RQIEASSRQTEASNRQTEA
SS-------------------------R--QTE---------ASSRQTETSN----RQIG
AS--NRQIMASNRQI---------------GASNR--Q-IEASNR-QIGASNRQTEVSSR
-----QIE-A------SNRQIGASNRQTEASNRQIGASNRQTEASNRQIGAS----NRQT
DASNRQTDASNRQTEA--------SSRQTEASSR---------QTE--A--SSRQTEASS
RQIEA--------------------S---------------------------------A
AAVRPKKPRGKKGNNKGS---------N------------SASEPSEAPPAIQTVTNHAL
SVTVRIRRGS----RARKA----ANKNRATESQA----QIAEQGAQAS----E-ASISAL
ETQ------------VA------------AAVQALADDYLAQL----SLEPTTRTRGKRN
RKS-----------------------------------------------KHPNGEERT-
GNNYRRIPWGRRLPP-PRDVAIL---QERANKLVK------YLLVKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LKDVIQEYEDYFPEIIERASYALEKMFRVNLKEIDKQNNLYI-LISTQES
SAG-IM-GTTKDT-PKLG---LLM----------VILSV----------IF--------M
-NGNK----A-S--EAVIWEVLRKLGLH--PGVKHSLFGEVKKLITDEFVKQK-------
---------YLEYKRVPNSRP---P--EYEFFWGLRSYHETSKMKVLKFACKVQKK---D
------PKDWAAQYREAVEMDIQAAAVAVA--EAKAR----AEARAQMGIGEEAV-----
------AGP--WNWDDMDINCLT-REELGDDAQAWS-RFSF----EIEPRAQENADPTTN
VLFNQGATTRNSFSDGAGISFGGITNP--SGGFGGISNPSGG--------FGGIS----N
PSGGFGGISNPSGGFGGISNPS----------GGFGGIS-----NPSGGFGGISNPSGGF
GGISNPSGGFGGISNPSGGFGGISNPSGGFGGISNPSGGFGGISNPSGGFGGISNPSGGF
GGISNPSGGFGGRNSITFGSVPNTSANFSSAPSISFGDTPNTSTSFSGGANSSFSGTPST
SAPFCNTASISFGGAPSTSTSFS-TASISFGGAPSTSTSLSTASISFGGAPSTSTSFSTA
SISFGGAPSTSTSLS-TASISFGGAPSINSS-SGGSSVSFGGAPT--TSTSFSGGPCISF
GGAPCTTASISGGASSGFGSTLCSTNPGFS-ALSTNTSFGSAPTTSTVFSGAVSTTTGFG
GTLSTSVCFGSSPYSGAGFGGTLSTSISFGGSPSTNTGFGG----TLSTSVSFGASSSTS
SDFGGTLSTSVSFGGSSGAN-AGFGGTLNSSTSFGGAISTSTGFGSALNNSANFGGAIST
SFSGVLNSSASFGGAINTSAGFGSTLNSSASFGSALSTSASFGGVLNGSAGFGGALNTNA
TFGGVLNGSAGFGGAMNTNATFGGALNSNAGFGGAISTSTNFGGALNNSAGFGGA-----
---------------MNTSASFGGALNNSAGFGGAISTNATFGGALNNS-AGFGGAISTN
ATFGGALNNSAGFGGAISTSASFGGTLNNSASFGGAINTSASFGGVLNNSAGFGGAINTS
ANFGGALTNSAGFGGAISTSASFGGALNNSAGFGGAISTSASFGGALNNSAGFGGAISTN
ASFGGAISNSPDFGGAFSTSVGFGGTLN-TTDFGSTHSNSISFGSAPTTSVSFGGSHSTN
LCFGGAPSTSLCFGSASNTNLCFGGSNST-NCFSGATSANFNEGHS----ISFGNGLSTS
AGFGNGLGTSAGFGSSLGTSTGFGGSLGPSASFNGGLGTSTGFGGGLGTSTDFSGGLNHN
ADFNGGLGNSAGFNGGLNTNTDFGGELGTSAGFGDGLGSSTSFGAGLVTSDGFAGNLGTN
TGFGGTLGTGAGFSVSLNNGNGFGNGPNASFNRGLNTIIGFGSGSNTSNGFTGEPNTGSS
FSNGPSSIVGFSGGPSTGAGFCSGPST-GGFGGGPSTGPGFGGPSTGP-GFGGPSTGGGF
GGPNTGGGFGGPSTGGGFGGPSTGGGFGGPSTGGGFGGPSTAAGFGSGLST---------
--STGFGGGLNTSAGFSGGPPSTGTGFGGGASSHGGCGFPYG

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------MAE-
----------------------------------------------------------GS
YR-----M-E-------SESYNVEDMDEGSDEVG--EEEMVEGNDYE----EFGAFGGYG
TLTSFDIRI--LRAFGSLG-----------------------------PGLRILSNEPWE
LENP-MLARTLI-------EAFQ--LDPETLANEAAARAA-------------NVARAAA
---S----------NRA-ARAA--------------------AAAARATYNQV---VASH
-------------------------------------------------LVAT-------
------DQASGEDTRPMTCPAE--AQ--------------------RATTETTLASPHSS
------QMLLNSEMAAPKAPAT-STQPQTAS---------------QAQ-----------
-------------EAA----------------TEGPSTACAFSQAPGASEME-ATRPKTA
FLGQ----------------------------NDVFD-------FTQPAGV---------
----SGMAFPRPKRPAPAQEA--ATEGPSA---------AS-GVPQAASAREGAATRPKT
T-----------------------------K-----------------------------
------------------------------------------------------------
--------------------------------------------------------SGKA
LAKTRWVEPQNVVAAP--------AAKA-KMATS---------IPEPEGAAA---PAQHS
AE-----------------------P---------------------------------W
ARMGGKRTKKSKHLDDEY--------ESSE-EEREPPAVPPTWRASQPPLA---------
---------V----R---------------------------------------------
----------------------------------------AQMA----------------
-----------------PRPP-----------------------------M----A----
-LRSQVPSRHVLCLP-PRNVTLL---QERANKLVK------YLMIKD-YKKIPI--KR--
------------------------------------------------------------
----SDM---LKDVIREYDEHFPEIIERATYTLEKKFGIHLKEIDKEEHLYI-LVCTRDS
SAR-LL-GKTKDT-PRLS---LLL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPFLGDLRKLITDDFVKQK-------
---------YLEYKKIPNSSP---P--EYEFLWGLRARHETSKMRVLRFIAQNQNR---D
------PREWKAHFLEAVDDAFKTMDVDMA--EEHAR----AQMRAQMNIGDEAL-----
------IGR--WSWDDIQVELLT-WDEDGDFGDAWA-RIPF----AFWARYHQYILNSNR
ANRRA------TWRAGVSSGTNGGASTSILDGPSTS-ST---IRTRNAARTS--------
----ANFFSWIQ------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------MPRGQA---SKRRAREKR-RQA
-RG-----EDQCL-----------------------------------------------
-RG-------------AQATAAEK------------------------------------
-----------------------------------------------------------E
-KLP-------------------------SSSSP-----A---------------CQSPP
QSFP-N-------------------------AGI----------------PQESQR---A
S--YP-NSLASA------------------------------------------------
------------------------------------------------------------
-----------------IS----LTSSDEGA---------------KG-Q-KG-ESP---
-----------------------------NS-FHGPSSSESTGRDLLNTKTGELV-----
-------QFLLNKYIRKEPIT-REAML--KVINRKYK-----QHFPEILRRSTEN-----
----VEVVFGLY---------LKE-MDPSR---------QSYV-----------------
-------L----------------------------------VSKLDF-PNQ---GSL-S
----DGRGFPLSGLL-------MVLLSTIFMHGNR------ATEE---EMWECLNAL---
-----GMY-KGR----KHFIYGEPQELVTKDLVRE------GYLEYQQV-PSSDPPRYEF
----LWGPRARAETS--KMKVLEFVAKLNDTVAS----T-YKSRYEE---ALREEEEQAR
AR-AAARASAR-AR----------------------------------------------
----------------------------------------------------------AS
--------------------RYF--Q-----------------------P----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------

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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------MPRGQK---SKLRAREKR-HQA
-RR-----ETQNL-----------------------------------------------
-GG-------------AQATAAQR------------------------------------
-----------------------------------------------------------E
-ESP-------------------------SCPSS-----P---------------SRGTP
PSSP-A-------------------------AGT----------------RQEPQG---A
P--AT-SSRAAG------------------------------------------------
------------------------------------------------------------
-----------------VS----GPGSDVRA---------------KV-R-VE-ARK---
-----------------------------NS-SQASASGESFQRDPLIKKVGMVI-----
-------EFLLEKYTVEEPII-KADLL--KLVNKRYK-----RKFPEILRRAAEC-----
----VQLVFGLE---------LKE-VKPGG---------DSYA-----------------
-------L----------------------------------VSKLHV-SDD---GRQ-S
----SGGRFRKNGLL-------MLVLGVIFLHGDR------ASEE---EIWEFLNGL---
-----GVY-VGR----CHIIFGEPRKLITEDLVQE------KYLVYRQV-CDSDLPCYEL
----LWGRRAHAETS--KMKVLEFMAKVTGTVPS----A-LPDLYEE---ALKDEEERAR
AR-ARARAAAR-AGTC--V-----------------------------------------
--------------------------K-------------------------------AS
--------------------APS--K-----------------------VMSS-SSSH--
P-----------------------------------------------------------
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---------------------------------------MSDT-----------------
---------------SE-SGA----------------------------GITRFQAEASE
KDSS-LMMQTQL-------TVTQ--NVEAPETPKAS------------------KA----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------PEVSEDVKDS-------KASGVS---------------KAT-----------
-------------EV---------------------------SKTPEAQEAP-ATQASST
-TQLTDTPVPAA----EN--KSPAADT--KKQNVDPQ-------AVTMPAT---------
----ETKK-----ASC--------------------------------------------
------------------------------------------------------------
--------------------------------------------------------VA--
-------------------------------DMKV-------------------------
----S-A--KAQETEA--------AASQAPADEP---------EPEPESTAVQAPENQDT
RPRVK--------------------A---------------------------------K
KARKVKHLHGEEDGS---------------SDQSQASGTIGGRSVSKALMASMAHRASRS
PIAFWARRAS----RTRLA----A------------------------------------
------------------------------------WARRALL----SLRSPKARRSKAR
RRA---------------------------------------------------------
-AKLQS-FQEPEAPP-PGDVALL---QGRANDLVK------YLLAKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LKDIIKEYTDVYPEIIERAGYSLEKVFGIQLKEIDKNDHLYI-LLSTLEP
TDAGIL-GTTKDS-PKLG---LLM----------VLLSI----------IF--------M
-NGNR----S-S--EAVIWEVLRKLGLR--PGIHHSLFGDVKKLITDEFVKQK-------
---------YLDCARVPSSNP---P--EYEFYWGLRSYYETSKMKVLKFACKVQKK---Y
------PKEWAAHYREAMEVDLKAAAEAAA--EAKAR----TEIRARMGIELGAE-----
----NAAGP--CNWD-------------DADIGPWA-KARIQAGAEAKAKGQESG--SAS
TGTSTST------NNSA------SASI--SDGFSAGTSLTATLTVGLFAGLGGA------
--GACG-FSYK-------------------------------------------------
------------------------------------------------------------
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------------------------------MPR---------------------------
----------------------GQKSK-------------------------------TR
--------------------SRAKRQ-QSRRE------VPVVQP--TAEEAGS-SPV---
----------------------DQSAGSS-FP---GGSAPQGVK-T-------------P
---------GSFG---A----------------GVSCTGSGIG---------GRNAAVLP
DTKSSDGTQAGTSIQ-HTLKDPI---MRKASVLIE------FLLDKF-KMKEAV--TR--
------------------------------------------------------------
----SEM---LAVVNKKYKEQFPEILRRTSARLELVFGLELKEIDPSTHSYL-LVGKLGL
STEGSL-SSNWGL-PRTG---LLM----------SVLGV----------IF--------M
-KGNR----A-T--EQEVWQFLHGVGVY--AGKKHLIFGEPEEFI-RDVVREN-------
---------YLEYRQVPGSDP---P--SYEFLWGPRAHAETTKMKVLEVLAKVNGT---V
------PSAFPNLYQLALRDQAGGVPRRRV-QGKGV-------------HSKAPSQKSSN
M-----------------------------------------------------------
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--------------------------------------MPLEQ-----------------
-----------------RSQ-HYKPE-E----------------RLEA----RGE-ALG-
-------------LVGAQASATEE------------------------------------
-----------------------------------------------------------Q
E-T---------------------------------------------------------
------------------------------------------------------------
----PSSSSTVV----EVT--RGE------------------------------------
---------VP--------------------------------------AS---------
---SGAST---LPTTIS-Y--TLWSQSDE----------------DSSN--QEEEGP---
------------S------AFSDL---------------ESSFQAALSRKVAELV-----
-------HFLLLK----EPVT-KAEML--ESVMRNCQ-----YFFPVIFCKASDS-----
----LQLVFGIE---------LME-VDPIG---------HLYI-----------------
-------F----------------------------------VTCLGL-SYD----GLLG
---DN-QIMPKAGLL-------IILLA-ITKEGDC------APEE---KIWEELSVL---
-----EVF-EGR----EHSIFADPRKLLTHDFVQE------NYLEYWQV-PGSDPACYEF
----LWGPRALVETS--YVKVLYHMLKISGGPHF----S-YSPLHEW---ALRDREE---
------------------------------------------------------------
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--------------------------------------------------------MAE-
----------------------------------------------------------GS
FG-----V-Q-------SENYSVEDMDEGSDEVG--EEEMVEGNDYE----EFGAFGGYG
TLTSFDIHI--LRAFGSLG-----------------------------PGLRILSNEPWE
LENP-VLAQTLV-------EALQ--LDPETLANETAARAA-------------NVARAAA
---S----------NRA-ARAA--------------------AAAARSAFNQV---MASH
R-------------------------------------------------VAT-------
------PQVSGEDTQPSTYSA--AAQ--------------------GPTPEAPLASPQTS
------QMLVTSEMAAPGAPAT-SAQSQTGS---------------SAQ-----------
-------------EAA----------------TEGPSSACAFSRAPSASEVDTATRPNTA
FLGP----------------------------NDVFD-------FTQPAGV---------
----SGMAFPRPKRPAPAQEA--ATEGPSA---------AS-GVSQMGPGREVAATRPKT
T-----------------------------K-----------------------------
------------------------------------------------------------
--------------------------------------------------------SGKA
LAKTRWVEPQNVVAAA--------AAKA-KMATS---------IPEPEGAAA--ATAQHS
AE-----------------------P---------------------------------W
ARMGGKRTKKSKHLDDEY--------ESSE-EEREPPAVPPTWRASPPSLT---------
---------V----R---------------------------------------------
----------------------------------------AQLA----------------
-----------------PRPP-----------------------------V----A----
-PRSQIPSRHVLCLP-PRNVTLL---QERANKLVK------YLMIKD-YKKIPI--KR--
------------------------------------------------------------
----SDM---LKDVIREYDEHFPEIIERATYTLEKKFGIHLKEIDKEEHLYI-LVCTRDS
SAR-LL-GKTKDT-PRLS---LLL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPFLGDLRKLITDDFVKSQVSF----
----PLTPRYLEYKKIPNSNP---P--EYEFLWGLRARHETSKMRVLRFIAQNQNR---D
------PREWKARFLEAVDDAFKKMDVDMA--EEHAR----AQMRAQMNIGDEAL-----
------IGR--WSWDDIQVELLT-WDEDGDFGDAWA-RIPF----AFWARYHQYILNSNR
ANRRA------TWRAGVSSGTNGGASTSVLDGPSTS-ST---IRTRNAARAG--------
----ASFFSWIQHR----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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---------------------M-------SLVSQNARR----------------------
------------------------------------------------------------
------------------CNAEIT------------------------------------
-----------------------------------------------------------A
-DY---------------------------------------------------------
-----------------------------------------------------------S
D--GRGEIQA----------------TNASGP------------P-T-------------
---------------------------------------------------PM------L
----------VVDAPQ----CPQAPINPQCV---------------NTSQ-AV-------
---------QDT----N--DLEV--LID-EQSRRLGA---LRVHDPLEDRSIALV-----
-------NFMRMKSQKEGSIQ--QSEM--LEFLREYS-----DQFPEILRRASAH-----
----LDRVFGLN---------LRV-IDPQA---------DTYN-----------------
----------------------L-------------------VSKRGS-QIT----DRIA
----ESLDMPKASLL-------ALVLGHILLNGNR------AREA---SIWDLLLKV---
-----DMW---DKPQRINNLFGNTRNLLTTDFVRM------RFLEYWPV-YGTNPLEFEF
----LWGSRAHR--EITKM-----------------------------------------
------------------------------------------------------------
--------------------------E-------------------------------AL
K-----------------------F---VS----------------DAHDEEP-------
------------------------QSWPE-EYN------------KALEADKTKER---S
---------------------------------------------------------LT-
AG---L--------E-FWSED---TMNDKANDLVQ------LAISVS-EELLPI--HQ--
------------------------------------------------------------
----DEL---LAHTGKEFEDVFPNILNRATLILDMFYGLSLIEVDTSEHIYL-LVQQPES
EEEQVM-LESLER-PTQE---YVM----------PILGL----------IF--------L
-MGNR----V-K--EANVWNLLRRFSVD--VGRKHAI--------TCRLMRQR-------
---------YLECRPLSYSNP---V--EYELLWGPRAHHETTKMKVLEYMARLYRK---R
------PQDWPEQYREAVE-----------DEEARAKSEATTMFF----LGP--------
---M--------------------------------------------------------
------------------------------------------------------------
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--------------------------------------------------------MAE-
----------------------------------------------------------GS
YS-----M-E-------SESFTVEDMDEGSDEVG--EEEMVEGNDYE----EFGAFGGYG
TLTSFDIRV--LRAFGSLG-----------------------------PGLRILSNEPWE
LENP-VLAQTLV-------DALQ--LDPETLANETATRAA-------------NIARAAA
---S----------NRA-ARAA--------------------AAAARTASNDQ---VAFN
Q------------------------------------------------PVDT-------
------DQASGEDTQPMIYTK---SQ--------------------GATPETTPASSQIS
------QMQINSDMAAPGAPAT-PTQPQTAS---------------QAQ-----------
-------------EAA----------------TEGPSTTRTSSQALYASELD-ATQPKTA
FPGH----------------------------NDVFD-------FTQPAGV---------
----SGMAFTRPKRPAMAQEA--ATEGPSA---------AS-GVPQAASAREVAATQPKT
N-----------------------------K-----------------------------
------------------------------------------------------------
--------------------------------------------------------SGKA
LAKTRWVEPQNVVTAA--------AAKA-KMATG---------IPEPEGAAA---TIQHS
AE-----------------------P---------------------------------W
ARMGGKRTKKSKHLDDEY--------ESSE-EEREPPTVPPTWRASQPPLM---------
---------A----R---------------------------------------------
----------------------------------------SQVA----------------
-----------------PRPP-----------------------------M----A----
-LTSQIPSRHVLCLP-PRNVTLL---QERANKLVK------YLMIKD-YKKIPI--KC--
------------------------------------------------------------
----SDM---LKDVIREYDEHFPEIIERATYTLEKKFGIHLKEIDKEEHLYI-LVCTRDS
SAR-LL-GKTKDT-PRLS---LLL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLH--PGVRHPFLGDLRKLITDDFVKQK-------
---------YLEYKKIPNSSP---P--EYEFLWGLRARHETSKMRVLRFIAQNQKR---D
------PREWKAHFLEAVDDTFKTMDVDMA--EEHAR----AQMRAQMNIGDEAL-----
------VGR--WSWDDIQVELLT-WDEDGDFGDAWA-RIPF----AFWARYHQYILNSNR
ANRRA------TWRAGVSSGTNGGVSTSILDGPSTS-ST---IRTRNAARAG--------
----ANFFSWIQHR----------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
--------------------------------------MPQDQ-----------------
-----------------KSE-HCEPE-Q----------------GLQA----QRE-THG-
-------------QEGAQVPGGEE------------------------------------
-----------------------------------------------------------E
EAMKALSAS------AA-------------------------------------------
-TSSSC------------------------------------------------------
------SPLTLR----SLI--TEE------------------------------------
---------GS--------------------------------------AAGA---RSAP
QSPQGACP---SLTAIS-P--APSTLSAE----------------GPSSQ-IEEGAS---
------------S------QVEEG---------TSSQDTEPWRRNRLGQKVIHLV-----
-------KFLLLKNRRKEPTM-KAEIL--ALVIRNYN-----SHFPVIFRRALEV-----
----MQLIFGID---------MKP-AGPTG---------HSYV-----------------
-------L----------------------------------VPTLGL-AYD----GMPP
-G-GV-PSAPKSSLL-------ILVLGVMFLEGNC------AREE---KIWETLGMI---
-----GVY-AEQ----EHFIYSEPRRLLTQDWVQE------KYLVYQRG-SSSLPGCSEL
----LWGLRAHAETS--KMKVLGFLAKASGTDPS----S-FPSHYAE---ALREEEERGR
APVAARARTRA-------------------------------------------------
------------------------------------------------------------
-----------------------VG------CIH----------------SRA-------
------------------------------------------------------------
---------TSS---------------------TFSC-----------------------
------------------PL----------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
--------------------------------------MPRGQK---SKLRAREKR-RKA
-RD-----ETQGL-----------------------------------------------
-SV-------------PQVTEAEE------------------------------------
-----------------------------------------------------------E
-EAP-------------------------CCSSS-----V---------------SGGAA
SSPP-A-------------------------AGI----------------PQKPQR---A
P---TTAAAAAA------------------------------------------------
------------------------------------------------------------
----------------GVS----STKSKKGA---------------KGRQ-GE-KNA---
-----------------------------SS-SQASTSTESSSEDPLTRKSGMLV-----
-------QFLLYKYKIKESVT-KGEML--KIVGKRFR-----EHFPEILKKASER-----
----LNVAFGIE---------LNK-VNPNG---------HTYT-----------------
-------F----------------------------------NK-VDL-TDE---ESM-L
----SSWDFPRSRLL-------MPLLGVIFLNGNS------ATEE---EIWEFLNML---
-----GVY-DGE----EHSVFGEPRKLITQDLVQE------KYLEYKQV-PNSDPPCFQF
----LWGPRAYAETS--KMKVLEFLAKVNGTTPC----A-FPTHYEE---ALKDEEKAGV
------------------------------------------------------------
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-----------------RH--------------QE----MKEMNLNWND-EELV------
----LMDV----------------------------------------------------
--------LSS----S------SSSS----------------------------------
------------------------------------------------------------
---------------------------LSDLEV------TEE-VVS-GELIVP-------
------------------------KHLQS-TSPAGDNT------------AEMQAQGE--
---------SSSH-----------------------------------------------
AEEGPSSVQGAEVSE-PCGLEVL---YGKVAEMVG------FLLLKY-VSQELL--SE--
------------------------------------------------------------
----ADM---LSVVCPDEPGLWPVLFPQARECLQLTFGIEVVEVDPSSTY-V-LVTAVGF
RHAGLH-APTLAL-Q-SC---LLL----------FILGV----------II--------Q
-EGDC----A-S--EEAIWSALSMLGLQ--AGEQHAIFGDPRELLSKVWVQEQ-------
---------YLECRQVLGSDP---P--RSVFLLGPSAHAATHKVKVLEFLISARSR---A
------QDSFHL--------------LDETEQEVA-------------------------
------------------------------------------------------------
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---------------------------------------MDRRNDHGHRVPTFQ--G---
--------PLPPP--GSLGLP----------------------------FSPDVQSETTE
KDP-----------------------------PIASRSKK-------------NKNKKNS
IKPM----------DKT-TPT--PPPVPSANDNASNKPKVTLQALNLPMFTQISQASAT-
T------------------------------------------------EAPN-------
------IQASVTSQTQK--AKTMRVTP------KVSLTGSEDATTQLKPPLQALNLPVTI
PTIQT---PVANESANSLAS-TAVNKSKNAS---------------KAN-----------
-------------NAA----------------NKTAPSATEISLASAATHTA-TTQGQAA
-KETGSIQATAATVRSKKNSKGKRTPA--KTTNTDNE-------YASNR-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------QTGASNRQIGASNRQTETSS--------------
-----------RQTEA--------SNRQTEASNR---------QTE--A--SNRQTEASN
RQTEA--------------------S---------------------------------A
VAVRPKKPRGKKGNNKGS---------N------------SAPEPSEAPPAIQPATNHAL
SVTVRIRRGS----RARKA----ANKNRATESQA----QTTEPGAQAS----E-ASISAL
ETQ------------VA------------AAVQALADDYLAQL----SLEPTTRTRGKRN
RKS-----------------------------------------------KHPNGEERT-
GNNYRRIPWGRRLPP-PRDVAIL---QERANKLVK------YLLVKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LKDVIQEYEDYFPEIIERASYALEKMFRVNLKEIDKQNNLYI-LISTQES
SAG-IM-GTTKDT-PKLG---LLM----------VILSV----------IF--------M
-NGNK----A-S--EAVIWEVLRKLGLH--PGVKHSLFGEVKKLITDEFVKQK-------
---------YLEYKRVPNSRP---P--EYEFFWGLRSYHETSKMKVLKFACKVQKK---D
------PKDWAAQYREAVEMDIQAAAVAVA--EAEAR----AEARAQMGIGEEAV-----
------AGP--WNWDDMDINCLT-REELGDDAQAWS-RFSF----EIEPRAQENADPTTN
VNFNQGASTRNSFSDGVSISFGGIPNP---------------------------------
------------------------------------------------------------
----------------------------------------------SGGFGGISNPSGGF
GGIPNPSDGFGGRNSITFGSVPNTSANFSSAPSISFGDTPNTSTSFSGGAGSSFSGTPST
SAPFCNTASISFGGAPSTSTSFS-TANISFGGAPSTSTSFSTASISFGGAPSTSTSFSTA
SISFGGAPSTSTSFSSTP-ISFGGAPSISSS-SGGSSVSFGGAPT--TSTSFSGGTSISF
GGAPCTSASFNGGASSGFGGTLSTTSPGCN-ALSTSTSFGSAPTTSTVFSGAVSTTTGFG
GTLSTSVCFGSSPYSGAGFGGTLSTSISFGGSPSTNTGFGG----TLSTSVSFGASSSTS
SDFGGTLSTSVSFGGSSGAN-AGFGGTLNSSTSFGGAISTSAGFGNALNSSASFGGAINT
SFSGVLNSNASFGGAINTSAGFGSTLNSSASFGSALSTSASFGGVLNGSAGFGGAMNTNA
TFGGVLNGSAGFGGAMNTNATFGGALNSNAGFGGS-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------NSTNCFSGATSANFSEGHS----ISFGNGLSTS
AGFGNGLGTSAGFGSSLGTSTGFGGSLGPSASFNGGLGTSTGFGGGLGASTDFGGGLNHN
ADFNGGLGTSAGFNGGLNTNTDFGGELGNSAGFGDGLGSSTSFGGGLVTSDGFAGNLGNN
TGFGGTLGTGAGFSVSLNTGNGFGNGPNASFNRGLNTIIGFGSGSNTSNGFTGEPNTGSS
FSNGSSSIVGFSGGPSTGAGFCSGPST-GGFGGGPSTGPGFGGPSTGP-GFGGPSTGPGF
GGPSTGGGFGGPNTGGGFGGPSTGGGFGGPSTGGGFGGPSTAAGFGTGLSTNAGFGSGP-
STSTGFGGGLNTSAGFSGGPPSTGTGFGGGASSHGGCGFSYG

------------------------------------------------------------
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------------------------------------------------------------
-----MWVFPVSASLPLGSGSKRSVCGILLTRGDFQGSVWSPGKS---HLWSYSESC---
-----LLS----------------------------------------------------
------------------------------------------------------------
-------------------------LTIAIMPR---------------------------
---------------------GGQKSK---------------------------------
-LR-----------------AREKHQ-QARGQTRS---LQGAQVI---AAQEG-ESPSC-
-PC-------------------PVS-GD-------AAGPPQKSP-G------------VP
------------------------------PTSAA--AAPAVS------SRRLGKGAKSR
RPEGATSSKVPRSTE-SSQKELV---VRKAEVLMQ------YLMYKY-KTKDPI--LK--
------------------------------------------------------------
----REM---LKTVHKRFREHFPEILKIASRHMELVFGLELKELKPGGSSYT-LASLLDL
TYDK---SPSGDF-PKTG---LLL----------ALLGL----------IL--------H
--GYC----A-T--EDDVWEFLSTLGVT--DRSMHFAFGDVKKLLTEDLVQEK-------
---------YLEYHQVPGTDP---P--RYQFLWGSGAQIETGKIKVLEFLAKVTCS---D
------VSDFALYYEEALRDEKEKTQAKVA-AGSGATA----------------------
------------------------------------------------------------
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------------------------------------------

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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------MPRGQK---SKLRAKEKR-RQA
-RG-----GLEDL-----------------------------------------------
-ID-------------ALAILEEE------------------------------------
-----------------------------------------------------------E
-EYP-------------------------PSASA-----C---------------LKDVS
QS-S-L------------------------GGTSN-------N-------PHGLWE---A
Q--STSTSAT-A------------------------------------------------
------------------------------------------------------------
-----------------AS----HTRQPEGV---------------SH-Q-ME-ERP---
-----------------------------RC-TQDLAAADSFLRGPVGEKIIMLV-----
-------HYLLYKYQMKEPIT-KADML--RNVTQMSK-----SQFPVILRRASEH-----
----LELIFGLD---------LKE-VEPNK---------HIYV-----------------
-------L----------------------------------VNKLDL-GCD----AKLS
----DEAGVPKTGLL-------MTVLGIIFTNGNC------VAEE---EIWKVFNMM---
-----GLY-DGI----EHFMFGEPRKLLTKDLVKE------NYLEYQQV-PNSDPPRYQF
----LWGPRAHAETS--KMKVLEFLAKVNNTAPS----E-FSTWYTE---ALQDEEERAR
AR-VAAKARIS-AT----------------------------------------------
----------------------------------------------------------AG
--------------------ARS--K-----------------------VNSS-NSS---
------------------------------------------------------------
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------------------------------------------

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------------------------------------------------------------
----------MLPLSVGLWVPIAQLLPALLPAALTRVIMSSEQ-----------------
-----------------KSL-HCKPE-E----------------GLEA----QEE-ALG-
-------------LVGAQAPTTEE------------------------------------
-----------------------------------------------------------Q
E-A---------------------------------------------------------
------------------------------------------------------------
---AVSSSSPLV----PGT--LEE------------------------------------
---------VP--------------------------------------AAES---AGLP
QSPQGASA---LPTTIS-F--TRWRQPNE----------------GSSS--QEEEGP---
------------S------TSPDA---------------ESLFREALSNKVDELA-----
-------HFLLRKYRAKELVT-KAEML--ERVIKNYK-----RCFPVIFGKASES-----
----LKMIFGID---------VKE-VDPTS---------NTYT-----------------
-------L----------------------------------VTCLGL-SYD----GLVG
---NN-QIFPKTGLL-------IIVLGTIAMEGDS------ASEE---EIWEELGVM---
-----GVY-DGR----EHSVYGEPRKLLTQDWVQE------NYLEYRQV-PGSDPPRYEF
----LWGPRALAETS--YVKVLEHVVRVNARVRI----A-YPSLREA---ALLEEEEGV-
------------------------------------------------------------
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-----------------------SGCEDCEANKP--MAEGNS-T----------------
-----------------VPL-PCCQS-L----------------EAQG----ISQ-SQG-
-------------LEVTQVSRALE------------------------------------
-----------------------------------------------------------E
T-----------------------------------------------------------
------------------------------------------------------------
---HLS-SHSVM----PGS--LKED---P---------------------NAG-------
----------V--------------------------------------PYTP-------
QGPQT----------------TSPSKSDE----------------GPSSK-EREDSL---
------------S------TSQPLP------------DPENVLLDAVDTKAAMLV-----
-------NFLMFKYQMKEPVT-KADML--KIVIREHE-----VHFPEILLRASER-----
----MEMVFGID---------LKE-VDPAN---------HRYD-----------------
-------L----------------------------------LIKLGL-TYD----GMLP
---GE-VGMPKTGVL-------ILILAVIFMKGNR------ATEA---EIWEVLNVT---
-----GIY-SGR----KHFIFGEPRKLITEDFVKE------KYLEYRQV-ANTDPAQFEF
----LWGPRAHAETT--KMKVLEFLAKVHGTDPS----S-FPSQYEE---ALQDEEEKAR
ARIPGRAVSPS-------------------------------------------------
------------------------------------------------------------
-----------------------LA--------T----------------ASS----GV-
------------------------------------------------------------
---------KTG---------------------SFSH-----------------------
------------------T-----------------------------------------
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--------------------------------------------------MLQTPE---S
G--------------------------------------------------GLPVP----
-------QAE----------------------------GEKDGGHDGETRAPT-----A-
-SQE-------------------RPKEELGA---------------GREE-G--------
----------------AAEPALTRKGA--RA-LAAKALARRRAYRRLNRTVAELV-----
-------QFLLVKDKKKSPIT-RSEMV--KYVIGDLK-----ILFPDIIARAAEH-----
----LRYVFGFE---------LKQ-FDRKH---------HTYI-----------------
-------L----------------------------------INKLKPLEEE----E---
EEEDLGGDGPRLGLL-------MMILGLIYMRGNS------AREA---QVWEMLRRL---
-----GVQ-PSK----YHFLFGYPKRLIMEDFVQQ------RYLSYRRV-PHTNPPEYEF
----SWGPRSHLEIS--KMKVLGFVAKLHKKEPQ----H-WPVQYRE---ALADEADRAR
AKAR-AEASMRARA--------SARA------G---------------------------
------------------------------------------------------------
-IH----L------W---------------------------------------------
------------------------------------------------------------
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--------------------------------------------------MLQTPE---S
R--------------------------------------------------GLPVP----
-------QAE----------------------------WEKDGGHDGETRART-----A-
-SQE-------------------RPKEELGA---------------GREE-G--------
----------------AAEPALTRKGA--RA-LAAKALARRRACRRLNRTVAELV-----
-------QFLLVKDKKKSPIT-RSEMV--KYVIGDLK-----ALFPDIIARAAEH-----
----LRYVFGFE---------LKQ-FDRKH---------HTYI-----------------
-------L----------------------------------INKLKPLEEE----E---
EEEDLGGDGPRLGLL-------MMILGLIYMRGNR------AREA---QVWEMLHRL---
-----GMQ-PSK----YHFLFGYPKRLIMEDFVQQ------RYLSYRRV-PHTSPPEYEF
----SWGPRSNLEIS--KMKVLGFVAKLHKKEPQ----H-WPVQYRE---ALADEADRAR
AKAR-AEASMRARA--------SARA------G---------------------------
------------------------------------------------------------
-IH----L------W---------------------------------------------
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--------------------------------------MPRP-R----------------
-----------------KRR-RCMVE-G----------------QPEA----QSV-----
-----------------AVTME-E------------------------------------
------------------------------------------------------------
D-SS-----------------------SSSSTYSSSFPSSFSST----------------
-----------------------------------------------------------S
------SSYALT----SGN--SEEG--C--------------------------------
----------A--------------------------------------ASRA---SSP-
HSPPGAGS---SCTAMI-S--SPRSQVS-------------------ADS-EGEDSP---
------------G------SSQALP------------CGTSLSTGEIDVKVDELV-----
-------KYLLLKYLMQEPVS-KAEIL--SNIIRNYQ-----DHFAVIFREALEC-----
----MQLVFGLE---------LKE-IDPAS---------HTYI-----------------
-------L----------------------------------TIALEL-TYD----GMMT
---DV-QGIPKTGLL-------IMVLSIIFMEGNC------VSED---MVWSILNNI---
-----GLY-AGN----EHFIYGEPRKLITDNFVQE------GYLEYRHV-PGSNPPFYEF
----LWGPRAYAETT--KMKILTFLTSINGSDPR----S-FPVWYAE---ALRDEEQQE-
------------------------------------------------------------
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--------------------------------------MPRGHK---SKLRAREKR-RQA
-HG-----GTHSV-----------------------------------------------
-NN-------------AQATAAEE------------------------------------
-----------------------------------------------------------E
-RSP-------------------------SSSSP-----S---------------FGGPP
QSFP-A-------------------------VRT----------------PQGSQR---G
P--STTTAA-AG------------------------------------------------
------------------------------------------------------------
-----------------TS----GRRAPRGA---------------EG-Q-DE-GGP---
-----------------------------S---SARAPNERSRRDPLTRRVIMLS-----
-------QFLLSKYEMQERIT-KGKMM--KIINKRYK-----EHFPEILRRASEY-----
----IELVFGLD---------VKE-VDSKG---------QSYT-----------------
-------L----------------------------------VSKLEI-TEE---ENL-S
----GGRGFPKTGLL-------MPLLAMISMNGNR------ATEE---EMWEFLNVF---
-----GMY-DGK----THFIFGEPRKLLTKDLVQA------KYLEYRQV-PNSDPPCYEF
----LWGPRAQAEAS--KTKVLEFSDKVQDTNSG----A-FQALYKE---AWGDEEETAT
GG-EWAGACPE-AR----------------------------------------------
----------------------------------------------------------AG
--------------------SSD--R-----------------------ESAA-GPPI--
------------------------------------------------------------
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--------------------------------------MPRGQK---SKLRAREKR-QRT
-RG-----QTQDL-----------------------------------------------
-KV-------------GQPTAAEK------------------------------------
-----------------------------------------------------------E
-ESP-------------------------SSSSS-----V---------------LGDTP
SSSL-A-------------------------FGI----------------PQEPQR---E
P--PTTPAAAA-------------------------------------------------
------------------------------------------------------------
-----------------MS----CTGSDEGD---------------GS-Q-DE-ENA---
-----------------------------SS-SQASTSTERSLKDPLTRKTKMLV-----
-------QFLLYKYKMKEPTT-KAEML--KIISKKYK-----KHFPEIFRKVSQR-----
----TELVFGLA---------LKE-VNPTT---------HSYI-----------------
-------L----------------------------------VSMLGP-TND---GNQ-S
----SAWTLPRNGLL-------MPLLSVIFLNGNC------AREE---EIWEFLNML---
-----GIY-DGK----RHLIFGEPRKLITQDLVQE------KYLEYQQV-PNSDPPRYQF
----LWGPRAYAETS--KMKVLEFLAKVNDTTPN----N-FPLLYEA---ALRDEEERAG
AR-PRVAARRG-TTAM--------------------------------------------
--------------------------T--------------------------------S
--------------------AYS--R-----------------------ATSS-SSSHPM
------------------------------------------------------------
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----------------AVILYCLPSCPHSCLLPPTRVVMSQD-Q----------------
-----------------GSP-RSTHD-Q----------------HLQT----LSE-TQS-
-------------LEVAQVFKAME------------------------------------
-----------------------------------------------------------E
T-----------------------------------------------------------
------------------------------------------------------------
---FLSSSHPLV----PVN--LKEA---P---------------------TAK-------
----------T--------------------------------------ESSL-------
EGPQSSCS---SSIAIT-T--TSSSESDE----------------GSSSQ-EEEE-----
----------------------ATS------------DPENMPADALDQKV---------
-------------YQMKEPIS-KADVL--KIIIKDDE-----SHFSEIFLRASKR-----
----LEMILGLY---------VKE-VDPTT---------CSYG-----------------
-------L----------------------------------FIKLDL-TYD----GMLS
---GK-KGMPKTGLL-------IRVLGAIFMKGNR------ATEE---EVWEVL------
------IY-SGK----KHFIFGEPRELITKDFVKE------KYLEYQQV-ANSDPAQYEF
----LCGPRAKAETS--KMKVLEFLAKIHGTHPD----S-YPSQYEE---ALKDEEERAG
AKI---------------------------------------------------------
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------------------------------------------

------------------------------------------------------------
------------------MSL--VSQNSRRRRGGRAN---GR------------------
--------------------NSSGKGLPAAVPGPDVPQDPSDPKLLQ-GHSAS-------
---DG-----------------PGT------------SVLPT------------------
---------------PREGPST---------SVPPTAP---GGSSASGQLII-SEG-PNT
SELPIS---------------GEEG----PGTSRPPAVS---------------------
-----AGLNTAMSIPAAEGLS------TSVPPTAPKGSKA---SE-------HLDVSEGL
NI----------------------SE-QPHSDEGP--GVQPTL--------GEGLGTTVP
ATFSEESGIS-------------------VPLPSDEGLSTP-------VS--PTISEGPG
INVPSPASEAPS--------TS---VP-----PTASDG------------LG---INLPP
T------SAEGPSTSVLLSASEEPDISVSPPSA---------------EGLSTS------
------------------------------------------------------------
------------------------------------------MLPPSGEVQSTWVPPTIL
EGSSVNM---------PPTSKKGLRTSVR---------------PAARESPST-------
------------------------------------S---------------AEGRVTSL
----------QSI----------------------------------------------S
AEGFGIS---------AAAS----------------------------------------
------------------------------------------------------------
---C------------------------AAEGSATCGLLP---------------CGEGP
STSGTSGLHTL------GEGPS-PSQIPLGAEGLGA--S---A---M---ST--------
---------------------------AADNP----------------------------
------AAAALSCGA-----SAGMNLCKCTSLGLQK------------------------
-----------------------ASAPSVRP---------------K-------------
-------RSEGPLEFQVLRDSENSNSITIMGLGTAHVALTLKPQDPMEQNVAELL-----
-------QFLLVKDQSKYPIK-ESEMR--QFIVKEYR-----NQFPEILRRAAAH-----
----LECIFRFE---------LKE-LDHEE---------HTYI-----------------
-------L----------------------------------LNKLGPVPFE-----GLE
----DTPNGPKMGLL-------MMILGQIFLNGNQ------AREA---DIWEMLWRF---
-----GVQ-RER----RLSVFGNPKRLLSVEFVWQ------RYLDYRPI-TDCVPVEYEF
----YWGPRSHLETT--KMKILKFMAKIYNKDPM----D-WPAQYNE---ALEEDAVRDV
ADD---------------------------------------------------------
------------------------------------------------------------
----WRPVPHFRRPFFEE----------VSPE------------------LLA-PD----
-SD---------------------------------------------------------
---------APGY-------------------------P---------------------
---------SKYSPH-SWPESRL---ESKSRKLVQ------LFLLMD-STKLPI--PK--
------------------------------------------------------------
----KGI---LYYIGRECSKVFPDLLNRAARTLNHVYGTELVVLDPRNHSYT-LYNRREM
EDTEEI-VDSPNR-PGNN---FLM----------QVLSF----------IF--------I
-MGNH----A-R--ESAVWAFLRGLGVQ--NGRKHVI--------TCRYLSQR-------
---------YIDSLRVPDSDP---V--QYDFVWGPRARLETSKMKALRYVARIHRK---E
------PQDWPEQYREALEDEANRAEAGHR-PL----------VVRNLR-----------
------------------------------------------------------------
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--------------------------------------MSQLQ-----------------
-----------------KNP-ECTAD-Q----------------G-QT----CEE-TQG-
-------------LQVAAVPSNVEEPCPSSQSLMASSL-------------KSQ------
---NYEK-------------A----------------QSLQV---------SAISD---D
KEEP----------------------------CPSSHLMAS------------------S
LKDQTC---------------------------------------EETQGLE--------
-GPCPS-SHSLM----ASH---QD------------------------------------
---------DP--------------------------------------EDET---PSTS
GGLQSPCA---SSSESN-D--NLSNQEKQ----------------GYP-------VN---
------------P------PS--QS------------VTRDAPVMNINNKVDFLV-----
-------NYMLYKYQTKEIMS-MTDIL--TLIVKEDE-----GHFQEILTKAAQR-----
----MEMVFGLE---------VKE-IDPVN---------HCYA-----------------
-------L----------------------------------FIKLGL-TYD----GM--
HS-DQ-YSFPKTGLL-------ILILGIVFMKGNR------ATEE---EIWEVLNPM---
-----GIY-AGM----NHFIFGDPRQLITDEFVKE------QYLMYQPV-ANSDPVQYEY
----VWGPRTHLETS--KMKVLEFVAKVHGTDPT----F-FPSQYEE---ALIEEEERTL
AMILERAGPSF-------------------------------------------------
------------------------------------------------------------
-----------------------L-------SGE----------------NSG--A----
------------------------------------------------------------
---------MSS------------------------------------------------
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------------------------------------------

------------------------------------------------------------
------------------MSL--VSQNSRRRRRRRGA---KAT-----------------
----------AHNSSWGEMQALNAPGLPATIPGLDAPQGSSDPQILQ-SLCTF-------
---EG-----------------QNT------------SVLLT------------------
---------------PGEGPST---------SALPLAS---EGSNTSRQPTV-SER-SST
SLLLTP---------------S-GG----PITSKTPAVS---------------------
-----EGLSVLVPLTPSEGLS------ISVPPTPGESSST---FV-------PPTASDGH
ST-----------------------SGLITPNEGPHTTRLPNT--------SEGPGISGP
PSTSQGLIVS-------------------VLPTPGEGQSTS-------WL--STASEGSH
IS----------------------------------------------------------
---------------VPPTHREVLSTSLLPTAS---------------EGSHIS------
------------------------------------------------------------
------------------------------------------VPSTHREL-STLMPTASX
XXXXXXX---------XXXXXXXXXXXXX---------------XXXXXXXXX-------
------------------------------------X------------------XXXXX
----------XXX----------------------------------------------X
XXXXXXX---------XXXXXXXX------------------------------------
-----------------------------------------------------------X
XXXX------------------------XXXXXXXXXXXX---------------XXXXX
XXXXXXXXXXX------XXXXXXXXXXXXXXXXXXX--X---XXXXX---XXXXXXX--X
X--XXXXXXX----------------XXXXXX------------XXXXXXXXXX------
---XXXXXXXXXXXX-----XXXXXXXXAL-FVFPPPNFLK-------------------
------------------------ALLDEGP---------------T-------------
-------GAEGPMEFTHLRDCGQSHSLTIRGFSRSRIN-NLKPWDPMEQNVAELL-----
-------QFLLVKDQSKYSIR-ESEML--QYVVKEYH-----NQFPEILRRVAAH-----
----LDCIFRFE---------LRE-LDPEQ---------RTYI-----------------
-------L----------------------------------LNKLGPVPFE-----GLE
----ESPNGPKMGLL-------MMILGQIFLNGNQ------AKET---EIWEMLWRM---
-----GVQ-RER----RLSIFGNPKRLLSVEFVWQ------RYLDYRPI-TDCDPVEYEF
----FWGPRSHVETT--KMKILKFMAKVYNKDPM----D-WPEQYNE---ALEEDASRGA
AEG---------------------------------------------------------
------------------------------------------------------------
----WQALPHYRRHFFEE----------AAAE------------------VAT-PD----
-SE---------------------------------------------------------
---------ISTY-------------------------S---------------------
---------SKYPPH-SWPESRL---ESKARKLVQ------LFLLMD-STKLPI--PK--
------------------------------------------------------------
----KGI---LYYIGRECSKVFPDLLNRAARTLNHVYGTELVVLDPRNHSYT-LYNRREM
EEIEEI-VDSPNR-PGNN---FLM----------QVLSF----------IF--------I
-MGNH----A-K--ESAVWAFLRGLGVQ--SGRKHVI--------TCRYLSQR-------
---------YIDSLRVPDSDP---V--QYEFVWGPRARLETSKMKALRYMARIHRK---E
------PQDWPQQYREALEDEANRANVEHR-QF----------FVHNFR-----------
------------------------------------------------------------
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--------------------------------------MPRGQA---SKRRAREKR-RQA
-RG-----EDRCL-----------------------------------------------
-MG-------------AQATAAEK------------------------------------
-----------------------------------------------------------E
-KLP-------------------------S-SSP-----A---------------CQSPP
QSFP-N-------------------------AGI----------------PQESQR---A
S--YP-SSPASA------------------------------------------------
------------------------------------------------------------
-----------------VS----LTSSDEGA---------------KG-Q-KG-ESP---
-----------------------------NS-FHGPSSSESTGRDLLNTKTGELV-----
-------QFLLNKYIRKEPIT-REAML--KVINRKYK-----QHFPEILRRSTEN-----
----VEVVFGLY---------LKE-MDPSR---------QSYV-----------------
-------L----------------------------------VSKLDF-PNQ---ESL-S
----DGRGFPLSELL-------MVLLSTIFMHGNH------ATEE---EMWECLNAL---
-----GMY-KGR----KHFIYGEPQELVTKDLVRE------GYLEYRQV-PSSDPPRYEF
----LWGPRARAETS--KMKVLEFVAKLNDTVAS----T-FKSQYKE---ALREQEEQAR
AR-AAARASAR-AR----------------------------------------------
----------------------------------------------------------AS
--------------------RSF--Q-----------------------PY---------
------------------------------------------------------------
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------------------------------------------

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------------------------------------------------------------
---------------------------------------------------METQIRREG
LGCSPASIKRKKKKEDSG--HLGLQVSTMFSEDDFQST---EGAPSGPQI----------
---------QWSQDLPRVQVFRE----------QANQE---DRSPR-RTQRITGG-EV--
-----------------LWGPITQIFPTVWPADLTGVIMPLEQ-----------------
-----------------RSQ-HCKPE-E----------------GLQA----QED-NPG-
-------------LVGGAQALQAE------------------------------------
-----------------------------------------------------------E
Q-E---------------------------------------------------------
------------------------------------------------------------
---AASFSSTLN----VGT--LEE------------------------------------
---------VP--------------------------------------ATES---PSPP
QSPQGESS---SPTAMD-S--IFGSLSDE----------------GSSS--QEEEGP---
------------S------TSPDLI------------DPESFSQDILHDKIIDLV-----
-------HLLLRKYRVKGLIT-KAEML--GSVIKNYE-----DYFPEIFREASEC-----
----MQLLFGID---------VKE-VDPTS---------HSYV-----------------
-------L----------------------------------VTSLSL-SYD----GIQG
---DE-QSMPKSGLL-------IIVLGVIFMEGNC------VPEE---VMWEVLSIM---
-----GVY-AGR----EHFLFGEPKKLLTHDWVQE------KYLVYRQV-PGTDPACYEF
----LWGPRAHAETS--KMKVLEYIANANGRDPS----S-YPSLYED---ALREEEEGV-
------------------------------------------------------------
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------------------------------------------------------------
---------------------------------------MSDT-----------------
---------------SE-SGA----------------------------GPTRFQVKASE
KGG--NSMQNLL-------TVTQ--KLEVSEMPKAT------------------KA----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------PKVSEAAKVS-------KASGIS---------------KAT-----------
-------------EV---------------------------SKSPEAPEAA-ATQTSTT
-TQQTDTQVLAA----EN--KSPAADP--KVQKADLQ-------AMAMPAT---------
----QTKK-----VDC--------------------------------------------
------------------------------------------------------------
--------------------------------------------------------VA--
-------------------------------DLKV-------------------------
----N-T--KVPETEG--------AASQAGADE-----------PESEGAAVQVQINQDT
RPKVK--------------------A---------------------------------K
NAQKVKHLEGEEDAS---------------SDQSQASGTTGGRRVSKALMASMARRASRG
PIAFWARRAS----RTRLA----A------------------------------------
------------------------------------WARRALL----SLRSPRARRGKAR
RRA---------------------------------------------------------
-AKLQS-SQEPEVPP-PRDVALL---QGRANDLVK------YLLAKD-QTKIPI--RR--
------------------------------------------------------------
----SDM---LKDIIKEYTDVYPEIIERAGYSLEKVFGIQLKEIDKSDHLYI-LLSTLEP
TDAGIL-GTTKDS-PKLG---LLM----------VLLSI----------IF--------M
-NGNR----S-S--EAVIWEVLRKLGLR--PGIHHSLFGDVKKLITDEFVKQK-------
---------YLDYARVPNSNP---P--EYEFFWGLRSYYETSKMKVLKFACKVQKK---D
------PKEWAAQYREAMEADLKAAAEAAA--EAKAR----AEIRAQMGIGLGSE-----
----NAAGP--CNWD-------------EADIGPWA-KARIQAGAEAKAKGEESD--GAS
ASAGASA------------STSAGASA--SGGFSTRPSLTATLTFGLFAGLSGAGARTSG
SSGACG-FSYK-------------------------------------------------
------------------------------------------------------------
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------------------------------MPR---------------------------
----------------------ARKST---------------------------------
-FR-----------------AREKRH-QTQGDTHS---VKGARAT---ATEEE-GFPSS-
-SP-------------------SG--R-----------SRQSSL-T------------AP
---------ISQD---P-------------PRAHPTADAAGAR------SLRATRRAQGQ
GEGGPSSSGASAPAA-RSGEDPL---NQKKAMLLR------LLLKKY-SMNQPI--KK--
------------------------------------------------------------
----AEM---MKIVTRKYKEHFPELLRRVAQHMVLVYGLELQEADSKGENYI-LVDKVET
TEEEVM-GGGRVF-PKEG---ILL----------PLLGM----------MY--------T
-NGER----A-T--EEEVWGYLRKLGVY--RGEKHDIYGELRRLITNDLVEEK-------
---------YLEYRQVPNSDP---P--RYEFLWGPRAHTEATKIAVLEYVAECIDT---D
------PSAKSKVKKP-PKEEGEQASASAS-ARYCLRAKPRSC-------SHSS------
------------------------------------------------------------
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------------------------------------------

------------------------------------------------------------
------------------MSL--VSQNSRRRRRRVAK---ATA-----------------
----------H-NSSWGEMQAPNAPGLPADVPGSDVPQGPSDSQILQ-GLCAS-------
---EG-----------------PST------------SVLPT------------------
---------------SAEGPST---------FVPPTIS---EASSASGQPTI-SEG-PGT
SVLPTP---------------S-EG----LSTSGPPTIS---------------------
-----KGLCTSVTLAASEGRN------TSRPPTSSEEPST---SV-------PPTA----
-------------------------------SEGTSTSVPPTA--------YEGPSTSVV
PTPDEGPSTS-------------------VLPTPGEGPGTS-------VP--LAATEGLS
TSVQATPDEGPS--------TS---VP-----PTATEG------------LST---PVPP
T------RDEGPSTSVPATPGEGPSTSVLPAAS---------------DGQSIS------
------------------------------------------------------------
------------------------------------------LVPTRGKGSSTSVPPTAT
EGLSTSV---------QPTAGEGSSTSVP---------------PTPGGGLS--------
---------------------------------------------------------TSV
----------PPT----------------------------------------------P
GEGLSTS---------VPPTAT--------------------------------------
-----------------------------------------------------------E
DLST--------------------------SVPP-----T---------------PGEGP
ST-SVLP-IPG------E-GLS-TSVPPT-ASD-GS--D---T-SVP---PT-PGE----
G--ASTLVQP----------------TAPDGP--------------GSSVLPNP------
---GEGPSTLFSSSA-----SVDRNPSKCS-LVLPSPRVTKA------------------
----------------S------VDSDSEGP---------------K-------------
-------GAEGPIEFEVLRDCESPNSISIMGLNTSRVAITLKPQDPMEQNVAELL-----
-------QFLLVKDQSKYPIR-ESEMR--EYIVKEYR-----NQFPEILRRAAAH-----
----LECIFRFE---------LRE-LDPEA---------HTYI-----------------
-------L----------------------------------LNKLGPVPFE-----GLE
----ESPNGPKMGLL-------MMILGQIFLNGNQ------AKEA---EIWEMLWRM---
-----GVQ-RER----RLSIFGNPKRLLSVEFVWQ------RYLDYRPV-TDCKPVEYEF
----FWGPRSHLETT--KMKILKFMAKIYNKDPM----D-WPEKYNE---ALEEDAARAF
AEG---------------------------------------------------------
------------------------------------------------------------
----WQALPHFRRPFFEE----------AAAE------------------VAS-PD----
-SE---------------------------------------------------------
---------VSSY-------------------------S---------------------
---------SKYAPH-SWPESRL---ESKARKLVQ------LFLLMD-STKLPI--PK--
------------------------------------------------------------
----KGI---LYYIGRECSKVFPDLLNRAARTLNHVYGTELVVLDPRNHSYT-LYNRREM
EETEEI-VDSPNR-PGNN---FLM----------QVLSF----------IF--------I
-MGNH----A-R--ESAVWAFLRGLGVQ--AGRKHVI--------TCRYLSQR-------
---------YIDSLRVPDSDP---V--QYEFVWGPRARLETSKMKALRYVARIHRK---E
------PQDWPQQYREAMEDEANRADVGHR-QI----------FVHNFR-----------
------------------------------------------------------------
------------------------------------------------------------
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---MGT---EAQPVVKVVILHCLPSCPHSCLLPPTRVIMSQD-Q----------------
-----------------ESP-RCTHD-Q----------------HLQT----FSE-TQS-
-------------LEVAQVSKPLE------------------------------------
-----------------------------------------------------------K
T-----------------------------------------------------------
------------------------------------------------------------
---FLSSSHPLV----PGK--VKEA---P---------------------AAK-------
----------A--------------------------------------ESPL-------
EVPQSFCS---SSIAVT-T--TSSSESDE----------------ASSNQ-QEEDSP---
------------S------SSEDTS------------DPRNVPADALDQKVAFLV-----
-------NFMLHKYQMKKPIT-KADML--KIIIKDDE-----SHFSEILLRASER-----
----LEMIFGLD---------VVE-VDPTT---------HCYG-----------------
-------L----------------------------------FIKLGL-TYD----GMLS
---GE-KGVPKTGLL-------ILVLGVIFMKGNR------ATEE---EVWEVLNLT---
-----GVY-SGK----KHFIFGEPRELITKDFVKE------KYLEYQQV-ANSDPARYEF
----LWGPRAKAEAS--KMKVLEFVAKVHGSHPH----S-FPSQYAE---ALKEEEERAR
ARI---------------------------------------------------------
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---------------------M-------SLVSQNARQ----------------------
------------------------------------------------------------
------------------SSAETT------------------------------------
-----------------------------------------------------------A
-DY---------------------------------------------------------
-----------------------------------------------------------S
D--SQGEMQA----------------TNASGP------------A-T-------------
---------------------------------------------------SM------L
----------ALEAPH----GPEIPNDPQGA---------------GAPQ-AV-------
---------RDP----S--DIEV--LID-EQSRRLGA---LRVHDPLEERSVALV-----
-------NFMRMKSQSEGSIR--QSEM--LEFLKEYS-----DQFPEILRRASAH-----
----LDRVFGLN---------LRV-LDPQT---------DTYN-----------------
----------------------L-------------------ISKSGP-QTT----ERLA
----ETLDIPKAGLL-------ALVLGHILLNGNR------AREA---SIWDLLLKV---
-----DVI---DGSQRINNHFGNTRNLLTIDFVHM------RFLEYWPV-YGTNPLEFEF
----LWGSRAHR--EITKM-----------------------------------------
------------------------------------------------------------
--------------------------E-------------------------------AL
K-----------------------F---VA----------------EAHDEEP-------
------------------------WSWPE-EYN------------KALEADKAKER---S
---------------------------------------------------------QA-
AG---L--------E-FWSED---TMNDKANELVQ------LAISVA-EELLPI--HQ--
------------------------------------------------------------
----DEL---FANTGKEFQDVFPNILSRATLILDLFYGFSLIEVDTSEHIYL-LVPQPES
EEEQVM-LESLGR-PTQE---YLM----------PILGL----------IF--------L
-MGNR----V-K--EAKIWNLLQRFSVD--VGRKHAI--------TCKLMRQR-------
---------YLECRPLSYSNP---V--EYELLWGPRAHHEITKMKALEYMARFYGK---Q
------PQDWPEQYREAVE-----------DEEARARSEATAMFF----FGS--------
---I--------------------------------------------------------
------------------------------------------------------------
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-----------------------------------------MHTLLA-ATKDPL------
------------------------------------------------------------
-----AM---NPPVVKHP-----------------------KKTRPR-------------
-KPLLM-LLMKDT-PKLG---L-M----------VILTV----------IF--------M
-NNNK----D-S--EAVICEVLCKLGLH--PQAQHSLFGKVRKLITDQFVKQK-------
---------YLEYKKIPNSRP---P--EYELFWGLRSYNETIKMKVLKYAPQCTEE---R
------PKDWAVQYQEAVEMEIQAA--AVAVAEAEARAKARAQMG----IGE--------
---EDVAGPW--NWD-MDIGCLT-REELDDEAQAWS-RFSF----EIEPRAQKNADPSPN
INFSRIDSTTASFSDGASISFEGAPNP--SGGFGSGDGIT--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------CFGSCSTSTSFSNAVSISFDSIPSTS-----------------------
-----------------------------SRFSGGTSISIGGAPSASASDSFSGGANSSF
SGPSNTSTSVNDGASSGFGGTLN-ITSGFSDTLSISTSFTTASSTSTVLSGTLSTNAGFS
GTFS--------------------TSIRFSGSPSTNTAFDS----MLSTSVSFSGSSGTK
AYLSGTVSTRVCFDGSPSTS----------------------------------------
-----------------------------------------------------------A
SFGGIVNTSAGFSS----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------VVSTS
TGFSGSLYTTAEFAG------------------------------TPSNSMGFGGALNTS
LCFGGAPSTSVSFGGTPNTSLCFSGAPSTMPAWLK---------DCTSTGFKFGRGLSTS
AGFRGRLSTSTGFSGK--------------------------------------------
------------------------------------LGNTTGFGGRVGTSDGFGGRLGTN
VSFDSILDTSAGFSSGLSTSDGFGDGPNACFNGGLSTIIGFGSG-NTSTGFTGEPRISTG
FNGAPGSLVGFSSGPSNHAGFSGGPSS-SASFGGGV------------------------
------------------------------------------------------------
------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
--------------------------------------MPRGHK---SKLRAREKR-RQT
-QG-----DTHSA-----------------------------------------------
-DG-------------AQATAAEE------------------------------------
-----------------------------------------------------------E
-GSS-------------------------SSSSP-----P---------------FGGSP
PSSP-A-------------------------AAV----------------PQGPHS---I
P--PITTAAAGASGTR--------------------------------------------
------------------------------------------------------------
--------------------------AAGGA---------------EG-Q-DEGGP----
-----------------------------SS-SAAPAPTERSQRDPVTRRVSMLL-----
-------QLLLYKYKMKEPIT-KAEMM--KIVNKRYK-----EHFPDILRRASVH-----
----LEVVFGLE---------LKE-VDSKG---------QSYV-----------------
-------L----------------------------------VSKLEI-TKE----ENFI
----GSRGFPKNGLL-------MPLLGMIYGNGNW------ATEE---EMWAFLNVL---
-----GIY-DGK----RHFMFGEPRKL---------------------------------
------------------------------------------------------------
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----------------------------------MDRRNDYGYRMLPFQPKHLNGDERG-
GDNYRLVPWGWRPPP-PRDVALL---QERANKLVK------YLLVKD-QRS------P--
------------------------------------------------------------
----SNM---LKDVIKEYDEYFPEIIERASYALEKMFRVNLKEIDKQISLYI-LISTQES
SAG-IL-GTTKDT-PKLG---LLM----------VILSV----------IF--------M
-NGNK----A-S--EAVIWEVLRKLGLH--PGVRHSLFGEVRKLITDEFVKQK-------
---------YLECKKVPNSRP---P--EYEFFWGLRSYHETSKMKVLKFACKVQKK---D
------PKDWAAQYREAVEMEVQAAAVAEA--EAEAR----AEIPGLQ------------
---------------IMLINCSS--SSRGSKVHPWN-LCPY----SSISRYYQSAEGDTL
------------------------------------------------------------
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--------------------------------------MPRR-Q----------------
-----------------KSQ-LCKLE-N----------------ILQA----QRK-KQR-
-------------LVGAQLPTAEE------------------------------------
-----------------------------------------------------------K
K-AS-----------------------SFS------------------------------
------------------------------------------------------------
-----CFLSPLI----PGT--LAKV---P---------------------AAG-------
----------T--------------------------------------ANTL-------
QGPQRACS---SSTAIA-A--TPLSKSGE----------------G-SSK-QEGKRP---
------------S------TSQA---------------PLDPSSDVLYKKVGSLM-----
-------QFLGIKYITKEPVT-KADIL--RSVIKEYK-----DHYPVIFKATSEF-----
----MEVVFGID---------VKE-ADPSG---------HSYV-----------------
-------L----------------------------------TNTLNL-TYN----KMLR
---DE-RDMPKTGLL-------ILILGLIFMEGDC------APEE---KIWEVLHMM---
-----KVY-DGM----QDIVYGEPRKLITQDFVRK------KYLVYQQV-AGSDPPRYEF
----LWGPRAHAETS--KMKVLEYFTRINGIGTS----T-FPTLYEE---ALRDEKERAW
SRIITRSHATA-------------------------------------------------
------------------------------------------------------------
-----------------------MT--------S----------------ALF----RA-
------------------------------------------------------------
---------ISS---------------------RI-------------------------
------------------------------------------------------------
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-------MT--TN---------RKI--------TFYSL----------EEMCL-----PL
------------------G----DTHSVQGA---------------QA-T-ASEAPST--
----------SP-----------------LI-QMTVTPSQNFQRDPIVRRMRLLV-----
-------QFLLHKYKMKEPIT-KAEMM--KIINKKYK-----EHYPEMLRRVSEH-----
----MEMVFGLE---------MKE-VDSRS---------QSYV-----------------
-------L----------------------------------TSILEI-TSE----GHLN
----GTRGFPKIGLL-------LPILGMTYRNGCQ------ATEQ---EMWEFLNAL---
-----GIV-DGK----RHFIFGEPRKFITRDLVWE------KYLEYRQM-PNSDPPEYEF----LWGPRAYTETS--KKKVLEFLVKVNNIDTY----A-FHVLYEG---TWGYEERSADTVGW-GGF---------------------------------------------------------------------------------------------------------------N--------------------ARARA------------------------------RF---------------------------------------------------------------------------R-----------------------------------------------------------------AKSSK---A-SHPS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TN---------RKI--------TFYSL----------EEMCL-----PL------------------G----DTHSVQGA---------------QA-T-ASEAPST------------SP-----------------LI-QMTVTPSQNFQRDPIVRRMRLLV------------QFLLHKYKMKEPIT-KAEMM--KIINKKYK-----EHYPEMLRRVSEH---------MEMVFGLE---------MKE-VDSRS---------QSYV------------------------L----------------------------------TSILEI-TSE----GHLN----GTRGFPKIGLL-------LPILGMTYRNGCQ------ATEQ---EMWEFLNAL--------GIV-DGK----RHFIFGEPRKFITRDLVWE------KYLEYRQM-PNSDPPEYEF----LWGPRAYTETS--KKKVLEFLVKVNNIDTY----A-FHVLYEG---TWGYEERSADTVGW-GGF---------------------------------------------------------------------------------------------------------------N--------------------ARARA------------------------------RF---------------------------------------------------------------------------R-----------------------------------------------------------------AKSSK---A-SHPS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TN---------RKI--------TFYSL----------EEMCL-----PL------------------G----DTHSVQGA---------------QA-T-ASEAPST------------SP-----------------LI-QMTVTPSQNFQRDPIVRRMRLLV------------QFLLHKYKMKEPIT-KAEMM--KIINKKYK-----EHYPEMLRRVSEH---------MEMVFGLE---------MKE-VDSRS---------QSYV------------------------L----------------------------------TSILEI-TSE----GHLN----GTRGFPKIGLL-------LPILGMTYRNGCQ------ATEQ---EMWEFLNAL--------GIV-DGK----RHFIFGEPRKFITRDLVWE------KYLEYRQM-PNSDPPEYEF
----LWGPRAYTETS--KKKVLEFLVKVNNIDTY----A-FHVLYEG---TWGYEERSAD
TVGW-GGF----------------------------------------------------
-----------------------------------------------------------N
--------------------ARARA------------------------------RF---
------------------------------------------------------------
------------R-----------------------------------------------
------------------AKSSK---A-SHPS----------------------------
------------------------------------------------------------
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-------------------------------GPHHQPEMSQSRE---IPHC------TQE
-QH-----CAQGL-----------------------------------------------
-EA-------------AQASK-DP------------------------------------
-----------------------------------------------------------E
-EAS-------------------------LSSHS-----L---------------MPGNQ
EGAL-A------------------------AGAPS-------T-------SQGPQS---A
C--VAYAVTT-A------------------------------------------------
------------------------------------------------------------
-----------------LL----SGKLGEHS---------------SS-Q----------
---------------------------------EKEGEAENLPIDPLDEKVNLLV-----
-------QFLLQKYQKREPIT-KADMI--NDVIREHK-----DDFLEILRRVSER-----
----IELVFGVD---------LKE-VDPTS---------HTYA-----------------
-------L----------------------------------VNKLDL-TYD----ARLS
----DDEGMPKTSLL-------IIILGVIFMKGNR------ATEE---EIWEVLNMM---
-----DLH-SGR----DHFIFGEPRKFITKDLVRE------KYLEYRQV-PNSDPPRYEF
----LWGPRAHAEAS--KMKLLEFLTKIHESDPT----C-FPSQYEE---ALRDEAERAR
AR-VATEASTS-AK----------------------------------------------
----------------------------------------------------------AK
--------------------SCS--N-----------------------PRSS-SSSHP-
------------------------------------------------------------
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--------------------------------------MPRGQK---SKLRAREKR-RQA
-RE-----ELKEL-----------------------------------------------
-AG-------------AQATAPEE------------------------------------
-----------------------------------------------------------E
-ESP-------------------------SSPSP-----S---------------FKDVP
QSSS----------------------------ATE-------T-------PSNPQR---T
T--STTTNAA-T------------------------------------------------
------------------------------------------------------------
-----------------VS----YTRSNDGA---------------SN----E-EGP---
-----------------------------RS-SQDPTATEPLHRSPLDEKVFILV-----
-------YYLLYKYQMKEPIT-KADML--RNVIQNYR-----NHFHEILKRASDH-----
----LELIFGLD---------TRE-LDPYK---------HIYV-----------------
-------L----------------------------------INKLEP-NCD----GRVS
----DGSSLPKSGLL-------MLVLGVIFMKDNC------ATEE---QMWEVLNMM---
-----GIF-AGR----RHYIYGEPRKLLTQDLVKE------NYLEYRQV-PNSNPPRYEF
----LWGPRAHAETS--KMRVLEFVAKVHNTVPS----A-FPTWYEE---ALQDEEERAR
AR-AAARARTA-AM----------------------------------------------
----------------------------------------------------------AS
--------------------ARS--R-----------------------AMAG-VRSRAT
------------------------------------------------------------
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-----------------------------------------------------------G
I-----------------------------------------------------------
------------------------------------------------------------
----------F----------------------------P---------------LNW--
PLLQ--------------------------YASIS-------L-------LSCPRS---S
Q--PKQ------------------------------------------------------
------------------------------------------------------------
-----------------------------ET---------PRSL-SQQ-V----------
--------------------------------KPRHG-PSPSGP----------------
----------RAAPPKKMIIW-FPDMV--KDVIGSYK-----KWCRSILRRTSLI-----
----LARVFGLH---------LRL-TSLHT---------MEFA-----------------
-------L----------------------------------VKALEPEELD-----RVA
----LSNRMPMTGLL-------LMILSLIYVKGRG------ARES---AVWNVLRIL---
-----GLR-PWK----KHSTFGDVRKLITEEFVQM------NYLKYQRV-PYVEPPEYEF
----FWGSRASREIT--KMQIMEFLARVFKKDPQ----A-WPSRYRE---ALEEARALRE
ANPTA----------------------------------HYPRSSVSED-----------
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------------------------------MPQ---------------------------
----------------------RHKNK-------------------------------FY
--------------------THGKPH-QVWGDTQE---AQAS--AAAAPK-----EECP-
-SS---------------PSSAPHGSPLS-SP---AAGDRQELQ-G-------------A
---------MAPS---S-------------PDAGPSCAGSDEG-------------AQGL
EEESAGASQAAPATQ-STRKDPL---ARKARILVE------FLLEKY-TKKEPI--TQ--
------------------------------------------------------------
----NAL---MKIVSRKYRKHFPEILSTARECVELVFGLEMKEVDRSRNIYT-LISKLNL
GGN--------DC-PSSG---LLM----------VLLRV----------IF--------M
-NGNR----A-T--EEEIWEFLSMLGIY--AGRRHWIFGEPRRLITKDLVQKE-------
---------YLNYCQVPNSDP---L--RYEFLWGPRACADTSKMKVLEGPAKFHGR---V
------PSSFPDLYDEVLRDQAERAGLRGE-ARAPPMAEAFAPSRAKSR------SSSHI
------------------------------------------------------------
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--------------------------------------MPRKHK---NKSHGRLKR-HQV
-WR-----DTQEA-----------------------------------------------
-QA-------------SAAAAPKE------------------------------------
-----------------------------------------------------------E
-CP--------------------------SSPSS-----A---------------PQGSP
LSSP-A-------------------------AGD----------------RQELQG---A
M--APSSPDA-G------------------------------------------------
------------------------------------------------------------
-----------------PS----CAGSDEGA---------------QG-P-EE-ESA---
-----------------------------GA-SQAAPATQSTRKDPLARKARILV-----
-------EFLLEKYTKKEPIT-QNALM--KIVSRKYR-----QHFPEILSAALEC-----
----LELVFGLE---------MKE-VDRSR---------NIYT-----------------
-------L----------------------------------ISKLNL-GGN---DCP-S
----GEGGLPKSGLL-------MVLLGVIFMNGNR------ATEE---EIWEFLSML---
-----GIY-AGR----RHWIFGEPRRLITKDLVQK------EYLNYRQV-PNSDPPHYEF
----LWGPRACAETS--KMKVLEVLAKFHSRLPS----S-FPDLY---------------
------------------------------------------------------------
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--------------------------------------MPRGHK---SKHRAREKR-RET
-HG-----QSQDL-----------------------------------------------
-TG-------------PQTTAEKQ------------------------------------
-----------------------------------------------------------E
-EPR-----------------------SSPSSYP-----V---------------CQGAR
RKTS----------------------------DSS-------V-------PQESQG---A
S--PTASPDAGVSCSKSDVAA----KGQDEKS------------A---------------
---------SVSC---------SKS--------DVAAKGQDEENASTSPDASV-----PQ
GSQGVSLTA---SLDAGVS----CSKSDIAG---------------LNQ---DEESA---
-----------------------------VT-SQRAAFFKTTDRDPLNRKASALV-----
-------QFLQEKFEKKEIIL-KADML--KRVSKKYK-----EHLPEILKKTSNH-----
----LAVVFGVE---------LKE-MDSSG---------ESYT-----------------
-------L----------------------------------VSKLGL-SGE----GILS
----GVNGLAKSGIL-------VSLLSFIFMRGNR------ATEK---EVWDFLGVL---
-----GIY-DGI----MHSVYGEPRKIIMEDLVQD------KYLEYRQV-YNSDPPCYEF
----LWGPRAHAETS--KMRVLRALASINNTAPG----S-YPHLYEE---ALIDEVERAL
RLRY--------------------------------------------------------
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--------------------------------------------------MLQKHK---S
R--------------------------------------------------IRPSS----
-------QGE----------------------------RDREWSRG--------------
-----------EE----------APSTSRGA---------------GGSQ-E--------
------------------PRGSASQGS--RR-SEAAPAVGPRTQKQLELKVAELV-----
-------QFLLIKDQRKIPIK-RADIV--KHVLGDYK-----DMFADLLRRAAER-----
----LQYVFGYK---------LVE-LEPKS---------HSFI-----------------
-------L----------------------------------INTLEPVEED----AEVR
----GDQGTPTTGLL-------MIVLGLIFMKGNT------IKET---EVWDFLRRL---
-----GVY-PTK----KHLIFGDPKKLITEEFVRQ------RYLEYRRI-PHTDPVDYEL
----QWGPRTNLETS--KMKVLKFVAKVHNQDPK----D-WPAQYCE---ALAEEEARAR
PQPQ-PSAPAPSS-----------------------------------------------
------------------------------------------------------------
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---------------------------------------MDRRNDSDCKMPLFQ--G---
--------PLPPP--GSLGLH----------------------------FPPDIQAETTE
EDSV-LLMHTLL-------AATK--DPLAMDPPVANRPKK-------------SKTKKAP
IKAI----------TKT-IPA--APPVPSANVITTNKPKITFHALNLPVIPQINQASAT-
I------------------------------------------------EASN-------
------TQASSSTTQPKKASKTKRITAKAVQG-SQFPAGSESVTIQIKSSLQALNLPVIP
QAIQA---PVASESANSQAL-LASTRPKKAY---------------KAK-----------
-------------KAD----------------NKGVASAAEISLAPSTAYTA-TIQGQIT
-ST-----------QTKNASKAKKATI--KGTNTDPE-------LLESPDA---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------TETAT
RQIEA--------------------S---------------------------------T
AAIWPKKSKGKKAANKGP---------N------------SVCEISDAPPATQMVTNQAL
AATLRVKRGF----RAQKV----ATKAWTTESQN----QI-EQGARAKMATSQ-TNVSAL
ETQ------------VA------------AAVQALADDYLAQL----SLEPTTRTQGKRK
QKY-----------------------------------------------KYLNGDERG-
GGIYRRIQWGRRPPL-SRDVAIL---QERANKLVK------YLLVKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LKDVIQEYDEYFPEIIERASYALEKMFRVNLKEIDKQSSLYI-LISIQES
SAG-IL-GTTKDT-PKLG---LLM----------VILSV----------IF--------M
-NGNK----A-N--EAIIWEVLRKLGLH--PGVRHSLFGEVRKLITDEFVKQK-------
---------YLEYKRVPNSRP---P--EYEFFWGLRSYHETSKMKVLKFACKVQKK---D
------PKDWAAQYREAVEMEVQAAAVAVA--EAEAR----AEARAQMGIGEEAV-----
------AGP--WNWDDMDIDCLT-REELGDDAQAWS-RFSF----EIEARDQENANASTN
IDFSRGASTRANFSDGASICFSGAPSP--SDG----------------------------
------------------------------------------------------------
------------------------------------------------------------
---------FGGRDGISFGSTCSTSATFSSTASISFGGTH--------------------
----------------YTSGSFSSAANICFGGMPNTCSTFSG----------------GA
SISFGGAASTSSSFSSEASISFGGTPCTSANFAGGVSPSFSGPLN--TSTSFSGGASSGF
GG------------------TL-SATAGFNDALITTTSFGSTLGTSAVFSGALSTSTAFG
GTLSTSVYFGGSPSSSASFGGTLSTSICFSGSPSTSTGFDG----VFSTSVSFGGSSSTS
TDFSGTLSTSVCFGDSLSTS-SSFGGALSTSVGFGGALSTSVGFGGALNTSAGF------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------SSAVSINTGFNSVPSTNSGFSSVFSTS
ADFSGALNTTTDFGSASS----------------------------------------TS
IGFGGAPSTSFCFGSLSNTNLCFGGPPSTNTCFSGPTNASFGDGLSTGAGFSFGDGLNTS
TGFSGGLSSSSSF-----------------------------------------------
---------------------------------GGGLSTSTGFGGGLISSDVFGGGLGTS
AGFGSTLGTRANFCSSLSISDGFGSEPNTSFDGGLSTIIGFASSSNTSTGFTGEPSTSTS
FIGGPSSIVGFGSGLSTDAGFNSGPSN---------------------------------
------------------------------------------------------------
-----------------------AAGFGGGGTSLGACSFSYG

------------------------------------------------------------
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------------------------------------------------------------
--------------------------------------MPRGQK---SKLRAREKR-QRT
-RA-----QTQDL-----------------------------------------------
-KV-------------GQATAAEK------------------------------------
-----------------------------------------------------------E
-ESP-------------------------SSSSS-----V---------------LGDTP
SSSL-A-------------------------LGI----------------PQKPQR---E
P--RTTPAAAAMSGTG--------------------------------------------
------------------------------------------------------------
--------------------------PDEGE---------------ES-Q-DEENA----
-----------------------------SS-SQASTSTERSLKDPLTRKTKMLV-----
-------QFLLYKYKMKEPTT-KAEML--KIISKKYK-----EHFPEIFRKVSQR-----
----TELVFGLA---------LKE-VNPTT---------HSYI-----------------
-------L----------------------------------VSMLGP-TND----GNQS
----SAWSLPRNGLL-------MPLLSVIFLNGNC------AGEE---EIWEFLNML---
-----GIY-DGK----RHLIFGEPRKLITQDLSLC------RNQQD-ES-PGV------F
----GQGE----------------------------------------------------
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------------------------------------MSRCYG-W----------------
-----------------RNQ-PCRPV-K----------------GLQV----HRK-APG-
-------------LV---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------DAQ--ALVV---S---------------------AAG-------
----------M--------------------------------------LSPP-------
QGPHRACS---CPTSIK-A--TPSIKSDQ----------------S-SSR-QQEEGP---
------------S------TLQAQP------------DGKSLIRDVTDDKVAHLV-----
-------LFLLLKYRTKEPIT-KTEML--NSVIKDYK-----DNFPVIFSEASEC-----
----MQLVFGID---------VKE-VDPVG---------HSYV-----------------
-------L----------------------------------VTALGL-TYD----GMLN
---D-FQSMPKTGLL-------INILGVIFLEGDC------APEE---VIWEVLGVM---
-----GVR-AGS----EHFIYGEPRKLITQDWVQE------GYLEYRQV-PDSDPTCYEF
----LWGPRAHAETS--KMKVLEFLAKGNDIIPN----A-FLIWYKE---AVRHEGKG--
------------------------------------------------------------
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---------------------------------RKYK-----EHFPEILRRDSER-----
----LELVFGLE---------LKE-VNPSS---------HSYA-----------------
-------L----------------------------------VCKLGL-PSD----ENLS
----GDRGLPKSGLL-------MTLLGVIFLKGNR------ATEE---EVWEFLGAL---
-----GVH-PGK----RHLIFGEPRRLITKDLVQQ------KYLEYRQV-PDSDPPRYEF
----LWGPKAHAETT--KMKVLEVVAKINGTVPR----A-FPKLYEE---ALKDEQERAG
VRAA-VRAAAR-AKALACSKAKSCSSSQVG------------------------------
------------------------------------------------------------
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------------------------------------------

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--------------------------------------MPHG-Q----------------
-----------------KSD-SCNLK-E----------------DLQA----PRE-AQG-
-------------LVGLQVPIVEE------------------------------------
-----------------------------------------------------------E
E-AT-----------------------STTT-----------------------------
------------------------------------------------------------
--TSFSSLSPLI----PGS--PEDL---P---------------------APG-------
----------I--------------------------------------LSLF-------
QSFQRACS---SSTAHT-V--TLSSLQ--------------------------EED----
-----------------PSTLQTPP------------NPESLFTEVLQNKVYDLV-----
-------QYLSIKYATKEPTT-KAEML--ESVIREHK-----DHFPVIFKKACEC-----
----LEVIFGIE---------VKE-VDPTS---------HSYV-----------------
-------L----------------------------------VKSLDL-TYD----GMLS
---D-DQVMPKTGIL-------ILILGIIFMEGNR------ASEE---RILEIMNMV---
-----GVR-DGK----NNFIYGDPRKLITKDLVQE------KYLEYQQV-PNSDPPRYEV
----LWGPRAHAETT--KMKVLKFLARINGTDPT----S-FTNLYEE---ALRDEREKAQ
AEVSSDD-TIA-------------------------------------------------
------------------------------------------------------------
-----------------------TT--------D----------------ESS----GV-
------------------------------------------------------------
---------LSS---------------------SFSC-----------------------
------------------PE----------------------------------------
------------------------------------------------------------
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---------------------------------------MDKRNDYSYRMPPFQ--G---
--------PLPPP--GSLGLP----------------------------FPPDVQTETTE
EDSV-LLMHTLL-------AATK--DPLAMDSSVANQPKK-------------SRTKKAP
IKTI----------TKA-APA--APPVPTANEIATNKPRITLQVLNLPIITQISQVSAI-
T------------------------------------------------GAAN-------
------IQASSITAQPKKANRMKRVTAKAAQG-SQSPTGSQVVTTQLKSPLQVLNLPVIS
QTIQA---PTASESANSQAL-IASTKPKKAS---------------KAK-----------
-------------KVA----------------NKAIANATEMSPAPIATYTA-TTPGQII
-SETVNIQATAASIRTKKSCKAKKTTA--KTTNTDTE-------HIGAPN----------
-------I----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------T
RQIEA--------------------S---------------------------------A
AAIRPKKSKGKKAANKGP---------N------------FASEIFKAPPATQMVTNQAL
AANLWVKRGS----RAQNT----ATKAQVTESLT----QISDQGAKAKMATAQ-TTISAL
ETQ------------VA------------AAVQALADDYLAHL----SLEPTTRTQGKRN
QKF-----------------------------------------------RHLNGDERS-
GSNYRRIPWGRRPPP-HRDVAIL---QERANKLVK------YLLVKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LKDVIQECDEYFPEIIERASYALEKMFRVNLKEIDKQSSLYI-LINNQES
SAG-IL-GTTKDT-PKLG---LLM----------VILSV----------IF--------M
-NGNK----A-S--EAVIWEVLRKLGLR--PGVKHSLFGEVRKLITDEFVKQK-------
---------YLEYKRVPNSRP---P--EYEFFWGLRSYHETSKMKVLKFACKVQKK---D
------PKDWAAQYREAVEMEVQAAAVAVA--EAEAR----AEARAQMGIGEEAV-----
------AGP--WNWDDMDIDCLT-REELGDDAQAWS-RFSF----EIEGRAQENADASTN
VNFSRGASTRASFSDGASISLSGAPSP--SGGFGGG------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------AGITF------------------------------------------
------------------------------SGVSSTSPSFSS----------------TA
CISFGGAPSTSSSFSSQASISFGGTPCTSTSFSDGVSSSFSGPLN--TSATFSGGASSGF
GG------------------TL-STTAGFSAVLSTSTSFGNVPTTSTVFSGALSTSTGFG
GTLSTSVCFGGSPSSGASFGGTLTTSICFGGSPNTNT--GG----TLSTSVSFCGSPNTS
ANFGGTLSTSVCFGGSPSTS-TDFGRI----AGFGGAVFTSTDFGSMLT-----------
----------------------------------------------NNSAGFGSAVCTST
NFGSTLSTSVCFGGSSSTSAGFGGGLNTGAG-----------------------------
----------------------------------------------------FGGSVCTR
TDFGSTLSTSVCFG------------------------------GSPSTSAGFG------
-----GLNTS----------ASFGSALNTSASFGGAVSTSAGFSVAPSNDSGFGSAFSTS
ADFSGALSTTTDFGGTPRNNMGFGGA----------PSMNISFGGAPSTSVRFGGAHSTS
LCFGGAPSTSLCFGSASNTNLCFGGPPSTSACFSGATCASFGDGPSTSAGFNFGNVLSTS
AGFGGGLST----------STGFSGGLGTNASFDDGLGTSTGFGGGLGTSSGFGGGLGTS
IGFGGGLGT------------------------------SAGFSGGLVTGDGFGGGLGTN
ADFGSTLGTSADFGGGLSTSDGFGSGPNASFNRGLSTIIGFGSGSNTSNGFTGEPSTSTG
FSSRPSSIVGFSGGPSTGAGFCSGPST-SGFGSGLNTGAGFS------------------
------------------------------------------------------------
-------SGPSTGVGFGGG-PSTGTGFS--ATSLGACGFSYG

------------------------------------------------------------
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--------------------------------------MPRFA-----------------
-----------------KCP-RLTLE-Q----------------EFQD----SDE-TQ--
------------------------------------------------------------
-----------------------------------------------QLSVEEVS----A
AEEEENIST------I------------------SSFSFSS-----L-------------
---SSC---------------------------------------S----------LPLT
LSASSS--SSLI----PST--PETDDKPA-------------------------------
-----SGLLN-----------------------------------------------LSH
CPQTFYSS----------S--ISCSISEQ----------------PSSL---AEESS---
------------S------IWQASQ------------DTDFLPKDSVEEKATQLM-----
-------NFLILKYRLKEAVT-KAEML--EFVIEDYQ-----DQFPGIFERASKC-----
----LEVIFGID---------IRE-VDPPS---------DFYV-----------------
-------L----------------------------------VNSLGL-TSC----EM--
LS-DD-FNMPKTGLL-------IVILGVIFIEDNR------ASED---SIWEFLSML---
-----GVY-PGR----EHFIYGEPWKLITNDWVQE------NYLQYQQV-PDSDPPKYEF
----LWGPRAYVETS--KMKVLEFLAKVNESDVI----S-FTYWYDE---ALRDEQERSQ
DKEGCVDSTTA-------------------------------------------------
------------------------------------------------------------
-----------------------CS------LLS----------------TDQ--Q--F-
------------------------------------------------------------
---------VLS---------------------QVNS-----------------------
------------------EADP------SPSLWRE------W------LEESCQ--VS--
------------------------------------------------------------
----K-------------------------------------------------------
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--------------------------------------------------MLREPE---S
R--------------------------------------------------GLPSP----
-------QAA----------------------------GEQHGGQDGETVALT-----V-
-SQEL------------------SIKEGLGA---------------M-RE-G--------
----------------AAEPAPTRQGA--RT-LAAKALARRRAYRRLNRTVAEVV-----
-------QFLLVKDKKKSPVT-RFEMV--KYVVGDLK-----DLFPEIIARAAEH-----
----LRYVFGFE---------LKQ-LDRKH---------HTYI-----------------
-------L----------------------------------IHKLKPLEE---------
-EEDLGGDGPRLGLL-------MMILGLIYMKGNS------VREA---QVWDMLRRL---
-----GVL-PSK----YHFLFGYPKRLIMEEFVQQ------RYLNYRRV-PHTNPLEYEF
----SWGPRSSLEIS--KMKVLGFVARLHKKEPQ----H-WTVQYRE---ALADEADRAR
AEAS-MRARVRARA--------SARA------G---------------------------
------------------------------------------------------------
-LH----H----------------------------------------------------
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-----------------GP--LEEV---D---------------------DSG-------
----------T--------------------------------------PRAP-------
KSPRGVFS---FPTADDAA--PPWSQSED----------------DTSSS-QDEERP---
------------S------TGLDPA------------DAKSSHPDPFHLKAADLV-----
-------GFLLLKYRTKEPTT-KEDML--NAVLRADQ-----DHFPVVLSQASEC-----
----LQLVFGVD---------VKK-VDPRE---------HLYV-----------------
-------L----------------------------------VPTLGL-TSD----GMLG
---GG-QSLPKNGLL-------VMLLGVILLEGEC------ATEE---KMWEALSVM---
-----GVY-PGR----EHFIYGEPRELITKAWVQE------GYLEYRQV-ANSDPARHEF
----LWGPRAHAETS--KLQVLEHFLRVNTRNLC----S-FLSLSEE---VLSNEENWP-
------------------------------------------------------------
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----------------------CKRE-E----------------DHQD----PRE-AQG-
-------------LVDAQLSGAEE------------------------------------
-----------------------------------------------------------E
E-AI-----------------------SPSSSPSVPFLGTL-------------------
------------------------------------------------------------
---------------------EE----VA---------------------VAA-------
----------T--------------------------------------TSPE---QG--
H--PSAQP---SPTAMA-A--TPWSQSRD----------------NGSSI-QDEEGP---
------------R------VWEDPG------------DAKSSLQDALRLKVSDLV-----
-------GFLLLKYRTKEPTT-KAEML--NTVLRDYQ-----DHFPVIFRQASEH-----
----MQLVFGID---------VKE-VDPSD---------HSYV-----------------
-------L----------------------------------VTTLGL-TYD----GMLS
---GE-QSMPKTGLL-------VMLLGVIHLQGDC------VPEE---DVWEALSVM---
-----GVR-AGR----EHFIYGEPRELITKVWVRE------QYVEYRQV-PSSDPARYEF
----LWGPRAHAETS--KMKVLEYFLRVSSR-----------------------------
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------------------------------MPR---------------------------
----------------------GNKSK-------------------------------GR
--------------------SRAKRQ-QTRGE-RQN--LQGAQSAAEE-EATS-PPL---
----------------------GQGDGPS-SP---EGCTPQGSQ-E-------------A
---------MPHG---S-------------PELDVPRSIYDVG------AEG SGSGAGAD
DDRRAHASKIAAAIL-SARRDPL---TRKANVLIE------FMLEKF-KVKKAF--TQ--
------------------------------------------------------------
----ADM---LRKISRKYKVHFTEILRRISVRLELVFGLELKEVDPSSQSYM-LVSKLGL
STEGSL-SNSTGL-PKTG---LLM----------TLLGV----------IF--------M
-KGNH----A-T--EEDISEFLKVVGIY--PGKSHVIFGEPWEFITKDLVKEN-------
---------YVIYRQVLGSDP---P--RYEFRWGPRAYAETTKMKVLEVVAKINNT---F
------PSFFPSMYEEAMLDEANRAARRFT-AVPGNAVDISDIREVRAHHRKCMTHSSSH
I-----------------------------------------------------------
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------------------------------------------

------------------------------------------------------------
------------------MSL--VSQNSRRRRRRGST---ATA-----------------
----------HNSGSWGEIQAPNASGLPAVMAGPDVPQGLSDPRILQ-GLCAS-------
---EG-----------------P-------------------------------------
------------------------------------------------------------
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-------------------NYESPNSITIMGLSTSQVAITLKPQDPMEQNVAELL-----
-------QFLLVKDQSKYPIR-ESEMR--EYIVKEYR-----SQFPEILRRAAAH-----
----LECIFRFE---------LRE-LDPEA---------HTYI-----------------
-------L----------------------------------LNKLGPVPFE-----GLE
----ENPNGPKMGLL-------MMILGQIFLNGNQ------AKEA---EIWEMLWRM---
-----GVQ-RER----RLSIFGNPKRLLSVEFVWQ------RYLDYRPI-TDCNPVEYEF
----FWGPRSHLETT--KMKILKFMAKIYNKDPM----D-WPEQYNE---ALEEDAARAL
AE----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------EYPPH-SWPESRL---ESKARKLVQ------LFLLMD-STKLPI--PK--
------------------------------------------------------------
----KGI---LYYIGRECSKVFPDLLNRAARTLNHVYGTELVVLDPRNHSYT-LYNRREM
EETEEI-VDSPNR-PGNN---FLM----------QVLSF----------IF--------I
-MGNH----A-R--ESAVWAFLRGLGVQ--SGRKHVI--------TCRYLSQR-------
---------YIDSLRVPDSDP---V--QYEFVWGPRARLETSKMKALRYVARIHRK---E
------PQDWPQQYREAMEDEANRADVGHR-QF----------FVHNF------------
------------------------------------------------------------
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----------------------------------------------------P-------
----------L--------------------------------------SELP-------
KLPQRAYF---SPTVMA-V--TPSIKSYQ----------------G-SSS-QEKEGP---
------------ST------SQALL------------DTGSLLRDAIEDKVADLV-----
-------GFLLLKYKTKEPIT-KAEVL--SSVIKEYK-----DHFPMIFDQVSEC-----
----MQLVFGID---------VKE-VDPTS---------HTYV-----------------
-------L----------------------------------VNTLGL-TCN----GMLN
---D-EQSVPKTGLL-------INILGVIFMNGNC------APEE---VIWKMLSVM---
-----GVY-DGR----EHFIYGEPRELLTRVWVQE------QYLEYRQV-PKSDPARYEF
----LWGPRAHVETT--KLKVLEFLTQINDTIPM----A-FPHCYEE---ALKDEEERSQ
GRFIVSENGAA-------------------------------------------------
------------------------------------------------------------
-----------------------RT------RVW----------------AYS----RA-
------------------------------------------------------------
---------TSI---------------------SFPC-----------------------
------------------PK----------------------------------------
------------------------------------------------------------
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--------------------------------------MPRGQA---SKRRAREKR-RQA
-RG-----EDRCL-----------------------------------------------
-TA-------------AQATAAEK------------------------------------
-----------------------------------------------------------E
-KLP-------------------------SSSSP-----A---------------CQSPP
QSFP-A-------------------------AGI----------------PHESQR---A
S--YP-SSPAAA------------------------------------------------
------------------------------------------------------------
-----------------VS----LTSSDEGA---------------KG-Q-KG-ESP---
-----------------------------NS-FHGPSSSESTGRDLLNTKTGELV-----
-------QFLLNKYIRKEPIT-REAML--KVINRKYK-----RHFPEILRRSTEN-----
----VEVVFGLY---------LKE-MDPSR---------QSYV-----------------
-------L----------------------------------VSKLDF-PNQ---GSL-S
----DGGGFPLSGLL-------MVLLSTIFMRGNR------ATEE---EIWECLNAL---
-----GMY-KGR----KHFIYGEPQALVTKDLVRE------GYLEYRQV-PSSDPPRYEF
----LWGPRARAETS--KMKVLEFVAKLNDTVAS----T-YKSRYEE---ALREEEEQAR
AR-AAARASAR-AK----------------------------------------------
----------------------------------------------------------AS
--------------------RSF--Q-----------------------P----------
------------------------------------------------------------
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------------------------------------------

------------------------------------------------------------
------------------LSL--VSQNSRR--LSSAK---ATE-----------------
----------HYSSSWGEMQAPKASGLLAAMLDPDAPEGSSDPQILQ-GLCVP-------
---EG-----------------PGT------------SILST------------------
---------------LGEGPRT---------AVPPAAS---KGSRASGSPTV-SEG-SNI
ALSVAA---------------S-EL----PNNPLPPTAP---------------------
---------------------------------------------------------EGA
SA----------------------SKHP----------SLPLS--------NEGPSISVP
PTFSEGLSTY-------------------LPPSSGEDRSAS-------LP--PTTSEGLS
ISVP--------------------------------------------------------
-----------------LTSGEEFSTTVLLTVS---------------EGPGIN------
------------------------------------------------------------
------------------------------------------VAFFSGEGPRTSVPPTVS
EESSPSR---------PPTPDKGLSTSEL---------------SAVSERPST-------
----------------------------------------------------------SM
----------LPL----------------------------------------------S
DEGPSIF---------IPTSFALP------------------------------------
-----------------------------------------------------------A
FEEQ------------------------VATLPP-----P---------------SGNNS
SI-SVLH-ISG------E-GSS-TSQMAN-ATE-GF--G---T-SGM---PT-ASE----
N--LGALLSS----------------NACGSQ----------------------------
-------------------------------------NSSNY------------------
----------------S------APADSKGP---------------K-------------
-------GADGPVEFQVLREHKNSNSITVMGLGTSQVALTLKPQDPMERNVAELL-----
-------QFLLVKDQSKYPIR-ESEMR--LHIVKEYR-----NQFPEILRRAAAH-----
----LECIFRFE---------LRE-LDPEE---------HTYI-----------------
-------L----------------------------------LNKLGPVPFE-----GLE
----DTPNGPKMGLL-------MMILGEIFLNGNQ------AKEA---EIWEMLWRM---
-----GIQ-RER----RLSIFGNPKRLLSVEFVWQ------RYLDYRPI-TDCTPVEYEF
----FWGPRSHLETT--KMKILKFMAKIYNKDPM----D-WPEQYNE---ALEEDAIRAA
ADD---------------------------------------------------------
------------------------------------------------------------
----WQAVPHFRRPFFEE----------I-------------------------------
--P---------------------------------------------------------
---------VSGY-------------------------P---------------------
---------SKYPPH-SWPESRM---ESKARKLVQ------LFLLMD-STKLPI--PK--
------------------------------------------------------------
----KGI---LYYIGRECSKVFPDLLNRAARTLNHVYGTELVVLDPRNHSYT-LYNRREM
EDAEEI-VDSPNR-PGNN---FLM----------QVLSF----------IF--------I
-MGNH----A-R--ESAVWAFLRGLGVQ--TGRKHVI--------TCRYLSQR-------
---------YIDSLRVPDSDP---V--QYEFVWGPRARLETSKMKALRYVARIHRK---E
------PQDWPEQYREAMEDEANRVDAGHR-QF----------LIHNIR-----------
------------------------------------------------------------
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--------------------------------------MPRGHK---SKVRAREKR-RQT
-RG-----DAQG------------------------------------------------
----------------AQATAAEE------------------------------------
-----------------------------------------------------------E
-RPC-------------------------TSSSL-----L---------------CDSNA
QGSS-A------------------------AG----------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------SRA---------------MS-Q-DG-ERP---
-----------------------------ST-SQALPTDDLSDGTPLDNRAIVLV-----
-------QFLLRKYNLKEPIT-KADML--KCVTKKYK-----KHFDEILKKASDL-----
----MVLAFGID---------VQE-VDSSR---------HHYA-----------------
-------L----------------------------------ISKLGP-SSD----ARLS
----GEEIMPKTGFL-------MTILCVIFMKGNR------ASED---EIWEVLNVM---
-----EIY-DGR----RHFIFGDARKLLTQDLVRE------EYLVYRRV-ANSDPPRFEF
----LWGPRAHAETS--KMKVLEFLAKIHNTVPS----A-FPILYEE---ALRDEEARTR
AR-FAAMIIAS-AR----------------------------------------------
----------------------------------------------------------VV
--------------------ALS--R-----------------------ANSG-NFSQ--
------------------------------------------------------------
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--------------------------------------MSHIQ-----------------
-----------------RHD-QG-FE-D-----------------QL-------------
---------------E--------------------------------------------
---------------------------------------------------EEVP-----
--A---------------------------------------------------------
---------------------------------------------------------AEE
VGTWEK------------------VA----------------------------------
---------AA--------------------------------------ES---------
-SQETASS----SASSQ-A--SASSKASE----------------GSGGE-AEGG-Q---
------------S------TSKACL------------RTKLLLNSKFQKKVIDLV-----
-------KFLSSKYITNEPVT-EAEIL--KSVGKKHK-----GYYSLIFKHACEC-----
----LEVVCGIE---------VKE-VDALN---------HTYL-----------------
-------L----------------------------------VKVLDL-TYD----GRIS
---NE-EGIPKTGLL-------VLVLGIIFMEGNR------ASEK---KIWEVLNIV---
-----GVY-PDQ----HDFICGNPRKFITEDLVLE------NYLVYQPV-PYSDPPSYEF
----LWGPRAQAETS--KMKVLQFFCKVAGSNPA----S-FAALYKE---ALEDEEERAR
ALLASTAIS---------------------------------------------------
------------------------------------------------------------
-----------------------TA------VDN----------------SGS--G--D-
------------------------------------------------------------
---------KPS---------------------GVSH-----------------------
------------------SE----------------------------------------
------------------------------------------------------------
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--------------------------------------MPHS-K----------------
-----------------KSQ-CCKLE-A----------------SHEA----QRR-AQN-
-------------PVDAQVPVTEK------------------------------------
-----------------------------------------------------------E
T-----------------------------------------------------------
------------------------------------------------------------
---ITSSLSPLI----QGT--PKVV---P---------------------AAG-------
----------K--------------------------------------PSVC-------
QSSQGVCS---SPSTIK-G--APLSKPNE----------------G-SSS-H-KEGP---
------------ST------SQAPP------------DPDSLLSEVLNQKVAELV-----
-------QFLSVKYVTKKPTM-AAEML--QSVIREHK-----GHFPVIFKKACEC-----
----MEVVFGIE---------VKE-VDPVN---------HSYE-----------------
-------L----------------------------------VKILNL-TYD----GMLS
---N-EQGMPKTGLL-------ILILGVIFMEGNC------APEE---KIWDMLNKI---
-----GVF-AGK----KDFIYGEPRKLITKDLVQE------KYLEYRQV-PNSDLPRYEF
----LWGPRAHAETS--KMQVLQFLAKVSGTAPT----S-FSSWYEE---AMRDERARAE
ARVAATDDTTA-------------------------------------------------
------------------------------------------------------------
-----------------------MA--------R----------------E---------
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------------------------------------------------------------
--------------------------------------MPRGQK---SKLRAREKR-RKA
-RE-----ETQGL-----------------------------------------------
-KV-------------AHATTAEK------------------------------------
-----------------------------------------------------------E
-ECP-------------------------SS-SP-----V---------------LGDTP
TSSP-A-------------------------TGI----------------PQKPQG---A
P--PTTTAAAA-------------------------------------------------
------------------------------------------------------------
-----------------VS----CTESDEGA---------------KC-Q-GE-ENA---
-----------------------------SF-SQATTSTQSSVKDPVAWEAGMLM-----
-------HFILRKYKMREPIM-KADML--KVVDEKYK-----DHFTEILNGASRR-----
----LELVFGLD---------LKE-DNPSG---------HTYT-----------------
-------L----------------------------------VSKLNL-TND---GNL-S
----NDWDFPRNGLL-------MPLLGVIFLNGNS------ATEE---EIWKFMNVL---
-----GAY-DGE----EHLIYGEPRKFITQDLVQE------KYLKYEQV-PNSDPPRYQF
----LWGPRAYAETT--KMKVLEFLAKMNGATPR----D-FPSHYEE---ALRDEEERAQ
VR-SSVRARRR-TTAT--------------------------------------------
--------------------------T-------------------------------FR
--------------------VRS--R-----------------------APFS-RSSHPM
------------------------------------------------------------
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--------------------------------------MPRGQK---SKLRAREKR-RQA
-RA-----KNAQ------------------------------------------------
--E-------------KEASPGPF------------------------------------
-----------------------------------------------------------Y
-GCP-------------------------H------------------------------
QASP-V-------------------------ASM----------------PTSPNM---P
M--GE-------------------------------------------------------
------------------------------------------------------------
--------------QSTFS----HSYTSTSD---------------QN-L-DE-------
-----------------------------KS-SDDSEDTEDWCKDPINHKVVLLV-----
-------QFLMEKYQKKEVIT-KADML--KYVIKTSK-----NHFNEILKRASEH-----
----MELAFGID---------LKE-VDPNR---------HCYA-----------------
-------L----------------------------------FNKLEH-TFD----GVMG
----E-EKMPSSGLL-------MIVLGVIFMNDNC------VSET---EIWNVLSMM---
-----GVY-ANR----KHFIYGDPKKVITEDMVQL------KYLEYQQV-PNSNPPSFEF
----TWGPRACAEIS--KMKILEFWAKIHDTTPD----S-FPTLYEA---ALKDEEERAQ
ARAV-ARA----------------------------------------------------
-----------------------------------------------------------H
--------------------TAAMA------------------------------SP---
------------------------------------------------------------
------------Y-----------------------------------------------
------------------SRATV---CSSS--HTN------I------------------
------------------------------------------------------------
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--------------------------------------MTLG-R----------------
-----------------MGE-LCKRE-E----------------DHQD----PRE-AQG-
-------------LVDAQLSGAEE------------------------------------
-----------------------------------------------------------E
E-AI-----------------------SPSSSPSVPFLSTL-------------------
------------------------------------------------------------
---------------------EE----VA---------------------AAV-------
----------T--------------------------------------RSPD---QG--
S--QSAWP---SPTAMA-A--TPWSQYGD----------------NGSSS-QDEEGP---
------------N------AWEDPG------------DTDSSLQDALRLKVTDLV-----
-------GFLLLKYRTKEPTT-KAEML--NTVLRDYQ-----DHFPVIFSEASEC-----
----MQLVFGVD---------VKE-VDPSD---------HAYV-----------------
-------L----------------------------------VTTLGL-TYD----GMLR
---GE-QIMPRTGLL-------AMLLGVILLEGNC------PPEE---GIWEALSVM---
-----GVR-AGR----EHFIYGEPRELLTHVWVQE------QYVEYRQV-PSSDPACYKF
----LWHPRAHAETS--KMKVLEYLLRVS-------------------------------
------------------------------------------------------------
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--------------------------------------MPHS-Q----------------
-----------------KNQ-SHKLE-V----------------GLQA----EKE-AQG-
-------------LMGSQVPVAEE------------------------------------
-----------------------------------------------------------K
K-A---------------------------------------------------------
------------------------------------------------------------
---TASLLSSLI----QGT--PEVS---V-------------------------------
----------------------------------------------------P-------
QSSQGGQQ---PRRESK-Q--LP-------------------------------------
-------------------------------------------------GSHILA-----
-------PVMWVKYVTKEPIT-KAEIL--ENVIKEHE-----DHFPLIFNKACEC-----
----MEIVFGIE---------AKE-VDPTS---------HSYV-----------------
-------L----------------------------------QKTLGL-TYD----GMLN
---D-GQSMPKTGFL-------IYILGVIFMEGN--------------------------
------LC-AGQ----KDFIYGEPRKLITKDLVEE------RYLEYQQV-PNSDPPCYEF
----RWGPRAHAETS--KMKILKFFSKVNGVDPT----S-FPSWYEE---ALRDEKEKAQ
ERAATGDATSA-------------------------------------------------
------------------------------------------------------------
-----------------------MA--------S----------------I---------
------------------------------------------------------------
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---------------------------------------------------METQIRREG
LGCSPAGIKRK-KKEDSG--HLGLQVSTMFSEDSFQST---EGAPSGPQI----------
---------QWSQDLPRVQVFRE----------QANQE---DRSPR-KTQRITGG-KV--
-----------------LWGPITQIFPTARPADLTGVIMPLEQ-----------------
-----------------RSQ-HYKPA-E----------------GLQA----QEE-DLG-
-------------LVGGAQALQAE------------------------------------
-----------------------------------------------------------E
Q-E---------------------------------------------------------
------------------------------------------------------------
---AASFSSTLN----MGT--LEE------------------------------------
---------VP--------------------------------------AAES---PSPP
QSPQGESS---SPTAMD-S--IFGSLSDE----------------GSNS--QEEEGP---
------------S------TSPSLI------------DPESFSQDTLHDKIIDLV-----
-------HLLLRKYRVKGLIT-KAEML--GSVIKNYE-----DYFPEIFREASEC-----
----MRLLFGID---------VKE-VDPAS---------HSYV-----------------
-------L----------------------------------VTSLSL-SYD----GIRG
---DE-QSMPKSGLL-------IIVLGVIFMEGNC------VPEE---VMWEVLSIM---
-----GVY-AGR----EHFLFGEPKKLLTHDWVQE------KYLVYRQV-AGTDPACYEF
----LWGPRTHIETS--KMKVLEYIANANGRDPT----S-YPSLYED---ALREEEEGV-
------------------------------------------------------------
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--------------------------------------MPRGQK---SKLRAREKR-RQA
-HG-----ETPGL-----------------------------------------------
-QA-------------AQAPAAEE------------------------------------
-----------------------------------------------------------E
-ASTPPSSPPSGGTPQSSPAAGRPPSPTTPPSSP-----P---------------SGGTP
QSSP-A-------------------------AGR----------------PQGPRR---S
P--SPTTPTK-A------------------------------------------------
------------------------------------------------------------
-----------------FA----SLRVDDGA---------------RC-P-EE-THP---
-----------------------------GP-SQAAGPMESYRRDPLTRKASMLV-----
-------AFLIERFKSKEPIS-KAAML--KIVNRKYR-----DQFPEILRRATLR-----
----LELVFGLE---------LKE-VDPSG---------QSYL-----------------
-------L----------------------------------ISKLDL-TTE---GSL-G
----GGGDLPKTGLL-------MTLLAVIFMKGNR------ATEE---EVWEFLNAL---
-----GVF-AGR----KHLIFGEPHQLLTEDLVQE------KYLEYRQV-PRSDPPCYEF
----LWGSRAHAETT--KMKVLEVLAKINDTVPS----S-FPVLYEE---ALRDEQERAA
AG-IPGRASLT-TL----------------------------------------------
----------------------------------------------------------VR
--------------------RRA--R-----------------------PSAS-SSF---
------------------------------------------------------------
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-----------------------------------------------------LV-----
-------KYMLLKYKMRELIK-RSEMV--KVIHRRYK-----AQFPEILSRASEH-----
----MEMVFGLV---------LKE-VRRNS---------HCYT-----------------
-------L----------------------------------VSNLDL-SDS----ESMR
----GDWGLPKNGLL-------MPLLGVIYLNGHR------ASEE---EVWKFLNIL---
-----GI-----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------YDGRMH-FIFGDTRK---LITEDLVQEEYLEYN-QVPGS-
-DP-------------------PRY-EF-------LWGPKALTE-NSK---TK VLQFLTK
---------VNNL---V-------------PDALLPHYE----------------EALRE
EAERTGARAASAAAE-ISHTDLL---TMESEN LVK------YMLLKY-KMRELI--KR--
------------------------------------------------------------
----SEM---VKVIHRRYKAQFPEILSRASEHMEMVFGLVLKEVRRNSHCYT-LVSNLDL
SDSESM-RGDWGL-PKNG---LLM----------PLLGV----------IY--------L
-NGHR----A-S--EEEVWKFLNILGIY--DGRMHFIFGDTRKLITEDLVQEE-------
---------YLEYNQVPGSDP---P--RYEFLWGPKALTENSKTKVLQFLTKVNNL---V
------PDALLPHYEEALREEAERTGARAA-TGTGPSAS---------------------
------------------------------------------------------------
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--------------------------------------MP--------------------
---------PVPGVP------FRNAD-N----------------NSPT----SVE-LED-
-------------W----------------------------------------------
-------------------------------------------------LDAQDP--TDE
EEEETS----------------------SISS-STFYLV-FSPSSFS-------------
------------------------------------------------------------
------PSSSLI----LGG--PEEEEVP----------------SGLIPSLAESIP---S
S----PPQSPP--------------------------------------QGPP---QGPS
QSPLSSGC--------S-S--FSWSSFSE----------------ESSSQ-KGED-T---
------------S------TCQGL------------PDSESSFTYALDEKVAELV-----
-------EFLLLRYEAEEPVT-EAEML--MIVI-KYK-----DYFPVILKRAREF-----
----MELLFGLA---------LIE-VGPD----------HFCV-----------------
-------F----------------------------------ANTVGL-TDE----GS--
---DD-EGRPENSLL-------IIILSVIFIKGNC------ASEE---VIWEVLNAV---
-----GVY-AGR----EHFVYGEPRELLTKVWVQG------HYLEYREV-PHSSPPYYEF
----LWGPRAHSESI--KRKVLEFLAKLNNTVPS----S-FPSWYKD---ALKDVEERVQ
AIIDTADDA-T-------------------------------------------------
------------------------------------------------------------
-----------------------VM------ASE----------------SLS--V----
------------------------------------------------------------
---------MSS---------------------NVSF-----------------------
------------------SE----------------------------------------
------------------------------------------------------------
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--------------------------------------------------------MAE-
----------------------------------------------------------GS
FG-----V-Q-------SENYSVEDMDEGSDEVG--EEEMVEGNDYE----EFGAFGGYG
TLTSFDIHI--LRAFGSLG-----------------------------PGLRILSNEPWE
LENP-VLAQTLV-------EALQ--LDPETLANETAARAA-------------NVARAAA
---S----------NRA-ARAA--------------------AAAARSAFNQV---MASH
R-------------------------------------------------VAT-------
------PQVSGEDTQPSTYSAA-ASQ--------------------GPTPEPPLASPQTS
------QMLVTSEMAAPGAPAT-SAQSQTGS---------------PAQ-----------
-------------EAA----------------TEGPSSACAFSRAPSASEVD-ATRPSTA
FLGP----------------------------NDVFD-------FTQPAGV---------
----SGMAFPRPKRPAPAQEA--ATEGPRA---------AS-GVSQMGPGREVAATRPKT
T-----------------------------K-----------------------------
------------------------------------------------------------
--------------------------------------------------------SGKA
LAKTRWVEPQNVVAAA--------AAKA-KMATS---------IPEPEGAAA--ATAQHS
AE-----------------------P---------------------------------W
ARMGGKRTKKSKHLDDEY--------ESSE-EEREPPAVPPTWRASPPSLT---------
---------V----R---------------------------------------------
----------------------------------------AQLA----------------
-----------------PRPP-----------------------------V----A----
-PRSQIPSRHVLCLP-PRNVTLL---QERANKLVK------YLMIKD-YKKIPI--KR--
------------------------------------------------------------
----SDM---LKDVIREYDEHFPEIIERATYTLEKKFGIHLKEIDKEEHLYI-LVCTRDS
SAR-LL-GKTKDT-PRLS---LLL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPFLGDLRKLITDDFVKQK-------
---------YLEYKKIPNSNP---P--EYEFLWGLRARHETSKMRVLRFIAQNQNR---D
------PREWKARFLEAVDDAFKKMDVDMA--EEHAR----AQMRAQMNIGDEAL-----
------IGR--WSWDDIQVELLT-WDEDGDFGDAWA-RIPF----AFWARYHQYILNSNR
ANRRA------TWRAGVSSGTNGGASTSVLDGPSTS-ST---IRTRNAARAG--------
----ASFFSWIQHR----------------------------------------------
------------------------------------------------------------
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--------------------------------------MSLEQ-----------------
-----------------RSL-HCKPE-E----------------ALEA----QQE-ALG-
-------------LVCVQA-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---AASSSSPLV----LGT--LEE------------------------------------
---------VP--------------------------------------TAGS---TDPP
QSPQGASA---FPTTIN-F--TRQRQPIE----------------GSSS--REEEGP---
------------S------TSRIL---------------ESLFRAVITKKVADLV-----
-------GFLLLKYRAREPVT-KAEML--ESVIKNYK-----HCFPVIFGKASES-----
----LQLVFGIE---------VKE-ADPTG---------HSYV-----------------
-------L----------------------------------VTCLGL-SYD----GLLG
---DN-QIMPKTGFL-------IIVLVMIAMEGGH------APEE---EIWEELSVM---
-----EVY-DGR----EHSAYGEPRKLLTQDLVQE------KYLEYRQV-PDSDPARYEF
----LWGPRALAETS--YVKVLEYVIKVSARVRF----F-FPSLREA---ALREEEEGV-
------------------------------------------------------------
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----------MPPKKKRKLPA-PKKHC--PVQ-----------GETQILQKAPAP-----
----KKQYQGKG-----KTQVLQESPAPKK---------HCPS-----------------
-------Q----------------------------------GKT-QV-LQE----GP-A
----PKKHCPGKGKT-------QVLQEGPAPKKHCPGQGETQVHQ---EGPATKKHC---
-----PGK----------------------------------------------------
------------------------------------------------------------
-------------------------GKIQVLQKGPAPKKHCPGQGETQVHQEAQAPKKHR
PVQGKTKVLQKSQVPKKHGPSQGKTQI-------------------------------LQ
ESQ-----------------APKKHG-RVQRKTQV---IQEAQAPATKKKILQ-SS-SA-
-SP-------------------LVV-TPG-TDSDS--HSQSSPE-E-------------A
---------VST-------------------------APA--------------------
-TNKSNPRSDETTKR-KKKKPAL---SKTVSTLVN------YIIEMY-KMKKTI--RK--
------------------------------------------------------------
----KDM---LMIINKKFKKHFPELLKRASFNIEVVFGMELKEVDATKHSYT-LVGKMNL
PYNGML-SRGRGF-PKTG---ILM----------NLLGV----------IF--------M
-KGNS----A-P--EEKIWEFLNKMKIY--DGQRHFLFGEPRKLITRDLVQLK-------
---------YLEHRQIPDSDP---P--QYEFLWGPRAYAETSKMKVLEFWAKINDI---T
------PTAFQSKYEEALKDEEEKADPIII-PSESSKDTKKKCSI----PGVEILPTIIE
VDEEE------DS-----------------------------------------------
------------------------------------------------------------
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------------------------------------------

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------------------------------------------------------------
---------------------MERRGLS----QQKKSYDWSPGRESEGTPVNRRRVPAST
T--VK--EGRPV-------------------------------------LRRAASSEQ--
---REE---SQTLPG-----------------------------------------I---
KVVVLC---HPPS---C-P-HS-------FPLPPREVSMSQGQE---IPFC------TQE
-QY-----SAHNE-----------------------------------------------
-IT-------------AISPS-KP------------------------------------
-----------------------------------------------------------D
-KGS--------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------SSQ-EKED---------------SS-A----------
--------------------------------SLSKSGTENLPVDPLDEKVTSLV-----
-------QFLLHKYQTKEPIT-KAEVL--DVVVKECK-----DHFLEILRRASKH-----
----MEVVFGVD---------VKE-VDPTR---------HTYA-----------------
-------L----------------------------------VNKLGL-TYD----ARLS
----GEEGMPKTSLL-------IIVLGVIFMKGNR------ATEE---EIWKVLNMM---
-----DLY-SGR----NHFIFGEPRKFITKDLVQE------RYLEYQQV-ANSDPPCYEF
----LWGPRAHAEAS--KMKLLEFFTEIHESDPR----C-FPSQYEE---ALRDEAERAQ
AR-LAARASTN-AM----------------------------------------------
----------------------------------------------------------SR
--------------------AHP--R-----------------------SRSL-SSSHP-
------------------------------------------------------------
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--------------------------------------MS--H-----------------
-----------------RHE-QG-R--E----------------GQL-------------
---------------S--------------------------------------------
---------------------------------------------------EEVP-----
--V---------------------------------------------------------
---------------------------------------------------------AKE
VGTSEG------------------ES----------------------------------
---------AA--------------------------------------QV---------
-PC---SS----SAPAQ------ATLPNE----------------GSAGQ-AGRR-Q---
------------S------VSKAYL------------FSRFLLNSQLQYKVTELV-----
-------KFLSFKYTTKQPVT-EAEIL--S-IVKEYK-----HYYQVIFKHACEC-----
----MEMVFGIE---------VKE-VDAIS---------HSYE-----------------
-------L----------------------------------LKVLDL-TYD----GRSS
GD-DD-EGIPKLGLL-------VFILGAIFMEGNR------APEK---KIWDMLNTV---
-----GVF-PDQ----HDFICGNPRKFITEELVSE------KYLEYQLV-PGSDPPCYEF
----LWGPRAHAETS--KMKVLQFFSRIVQSSPT----A-FTALYRE---ALKDEEERAQ
AALAS--MASP-------------------------------------------------
------------------------------------------------------------
-----------------------VA------PED----------------SGS--T--D-
------------------------------------------------------------
---------KPS---------------------SFSR-----------------------
------------------PE----------------------------------------
------------------------------------------------------------
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--------------------------------------MLLRQ-----------------
-----------------KRQ-SCKAE-E----------------GRQA----EGD-APG-
-------------LMDVQIPTTEE------------------------------------
-----------------------------------------------------------Q
K-A---------------------------------------------------------
------------------------------------------------------------
----ASSSSTLI----TGT--LEE------------------------------------
---------VP--------------------------------------DSGS---LSPP
QSPQGASS---SLTITN-D--TLWSQSNE----------------VSSS--NEEEGP---
------------S------TSPDLA------------HLESLFREALDEKVAELV-----
-------HFLLRKYQIKEPVT-KAEML--ESVIKNYK-----NHFPEIFSKASEC-----
----MQVIFGID---------VKE-VDPVG---------HCYV-----------------
-------L----------------------------------VTCLGL-SYD----GLLG
---DD-QSTPKTGLL-------IIVLSMILMKGSC------APEA---AIWEALSVM---
-----GLY-DGR----EHGVYWELRKLLTQEWVQE------NYLEYRQV-PGSDPVRYEF
----LWGPRALAETS--YVKVLEHVVRVNARVRI----S-YPSLHEE---ALGEEKGV--
------------------------------------------------------------
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--------------------------------------MPLEQ-----------------
-----------------RSQ-HCEPE-E----------------GLEA----RGE-ALG-
-------------LVGAQAPATEE------------------------------------
-----------------------------------------------------------Q
H-T---------------------------------------------------------
------------------------------------------------------------
----ASSSSTLV----EVT--LGE------------------------------------
---------VP--------------------------------------AAES---PGPT
QSPQGASS---FSTTIN-Y--TLWSQSDE----------------DSSN--QEEEGP---
------------R------MFPDL---------------ESEFQAALSRKVTELV-----
-------HFLLLKYRAREPFT-MAEML--ESVTRNCQ-----YFFPVIFSKASEY-----
----LQLVFGIE---------VME-VGPVG---------HLYI-----------------
-------L----------------------------------VTCLGL-SYD----GLLG
---DN-QIMPKTGLL-------IIVLAIIAIEGDC------APEE---KIWEELSVL---
-----EVF-DGR----EDSVFAHPRELLTQDLVQE------NYLQYRQV-PGSDPACYEF
----LWGPRALVETS--YVKVLYHMLKISEEPHI----S-YPPLHEW---ALREGEE---
------------------------------------------------------------
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--------------------------------------MSLEQ-----------------
-----------------RSQ-HCKPE-E----------------GLEA----QGE-ALG-
-------------LVGAQAPATEE------------------------------------
-----------------------------------------------------------Q
E-T---------------------------------------------------------
------------------------------------------------------------
----ASSSSTVV----EVT--LGE------------------------------------
---------VP--------------------------------------AAES---PGPP
QSPQGAST---LPTTNN-Y--TLWSQFDE----------------DSSN--QEEEGP---
------------S------TFPDL---------------ESGFQAALSRKVAELV-----
-------HFLLLKYRAREPVT-KTEML--GSVMRNCQ-----YFFPVIFSKASDS-----
----LQLVFGIE---------LME-VDPVG---------HLYI-----------------
-------L----------------------------------VTCLGL-SYD----GLLG
---DN-QIMPKAGLL-------IIVLAIIAKEGDC------APEE---KIWEELNVL---
-----EVF-DER----GDSIFADPRKLLTQDFVQE------NYLDYRQV-PGSDPACYEF
----LWGPRALVETS--YVKVLYHMLKISGGPHF----S-YPPLHEW---ALREGEE---
------------------------------------------------------------
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--------------------------------------MPLEQ-----------------
-----------------RSQ-HYKPE-E----------------GLEA----RGE-ALG-
-------------LVGAQASATEE------------------------------------
-----------------------------------------------------------Q
E-T---------------------------------------------------------
------------------------------------------------------------
----ASSSSTVV----EVT--LGE------------------------------------
---------VP--------------------------------------AAES---PGPP
QSPQGAST---LPTTNN-Y--TLWSQFDE----------------DSSN--QEEEGP---
------------S------TFPDL---------------ESGFQAALSRKVAELV-----
-------HFLLLKYRVREPVT-KAEML--GSVMRNCQ-----YFFPVIFSKASDS-----
----LQLVFGIE---------LME-VDPVG---------HLYI-----------------
-------L----------------------------------VTCLGL-SYD----GLLG
---DN-QIMPKAGLL-------IIVLAIIAKEGDC------APEE---KIWEELNVL---
-----EVF-DGR----EHSIFADPRKLLTQDFVQE------NYLDYRQV-PGSDPACYEF
----LWGPRALVETS--YVKVLYHMLKISGGPHF----S-YPPLHEW---ALREGEE---
------------------------------------------------------------
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--------------------------------------MPLEQ-----------------
-----------------RSQ-HCKPE-E----------------GLEA----RGE-ALG-
-------------LVGAQAPATEE------------------------------------
-----------------------------------------------------------Q
Q-T---------------------------------------------------------
------------------------------------------------------------
----ASSSSTLV----EVT--LGE------------------------------------
---------VP--------------------------------------AADS---PSPP
HSPQGASS---FSTTIN-Y--TLWRQSDE----------------GSSN--QEEEGP---
------------R------MFPDL---------------ESEFQAAISRKMVELV-----
-------HFLLLKYRAREPVT-KAEML--ESVLRNCQ-----DFFPVIFSKASEY-----
----LQLVFGIE---------VVE-VVPIS---------HLYI-----------------
-------L----------------------------------VTCLGL-SYD----GLLG
---DN-QVMP KTGLL-------IIVLAIIAIEGDC------APEE---KIWEELSML---
-----EVF-EGR----EDSVFAHPRKLLMQDLVQE------NYLEYRQV-PGSDPACYEF
----LWGPRALIETS--YVKVLHHTLKIGGEPHI----S-YPPLHER---ALREGEE---
------------------------------------------------------------
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--------------------------------------MPRGQK---SKLRAREKR-RKA
-RE-----ETQDL-----------------------------------------------
-KV-------------AHATAAEK------------------------------------
-----------------------------------------------------------E
-ECP-------------------------SS-SP-----V---------------LGDTP
TSSP-A-------------------------AGI----------------PQKPQG---A
P--PTTTAAAA-------------------------------------------------
------------------------------------------------------------
-----------------VS----CTKSDEGA---------------KC-Q-GE-ENA---
-----------------------------SF-SQATTSTESSVKDPVAWEAGMLM-----
-------HFILRKYKMREPIM-KADML--KVVDEKYK-----DRFIEILNGASRR-----
----LELVFGLD---------LKE-DNPSG---------HTYT-----------------
-------L----------------------------------VSKLNL-TND---GNL-S
----NDWDFPRNGLL-------MPLLGVIFLKGNS------ATEE---EIWKFMNVL---
-----GAY-DGE----EHLIYGEPRKFITQDLVQE------KYLKYEQV-PNSDPPRYQF
----LWGPRAYAETT--KMKVLEFLAKMNGATPR----D-FPSHYEE---ALRDEEERAQ
VR-STVRARRR-TTAT--------------------------------------------
--------------------------T-------------------------------FR
--------------------ARS--R-----------------------APFG-RSSHPM
------------------------------------------------------------
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------------------------------------------

------------------------------------------------------------
------------------MSL--VSQNSRR--CRGAT---ATE-----------------
----------HNGSSWGEIQAPNASGFPAAVPDPDAPQDHSDPQILQ-GLCAS-------
---EG-----------------PSA------------SVLPT------------------
---------------PGEGPST---------SGPPTIS---EGSSAYRQPTI-SEG-PST
SVLPTP---------------G-EG----PSTSGPPTVS---------------------
-----KGPNTSVLLTASERRS------ASGPPTSSEKPSA---SM-------PPNPGEGP
TS----------------------TSMPSTPGEGPSTSVPPTA--------SAGPGTSVP
PPLGEGPSTS-------------------VPPPLGERPSTS-------VP--PSLEEGLS
TSVPPPLGEGPS--------TS---VP-----PPLGEG------------PST---SVPP
P------LGEGPSTSVPPPLGEGPSTSMLSSAS---------------EGSGIS------
------------------------------------------------------------
------------------------------------------VPPPMGEGPSTSVPPTGP
S---TS-----------VPPTEGLSTSVP---------------PPLGEGPST-------
-------------------------------------------------------SVISV
----------PPP----------------------------------------------L
GEGPST------------------------------------------------------
------------------------------------------------------------
------------------------------SVPP-----P---------------LGEGP
ST-SVLP-PLG------E-GPS-TSVLPT-SSK-GS--S---T-SML---PA-RAQ----
G--LSAFMLP----------------TACEKP--------------SNSVPPIP------
---PEGHSTLLSSGA-----FAGRKPSKCS-SVLPNRSMAKA------------------
----------------S------ADSDSEGP---------------K-------------
-------GAEGPLEFQVLRDRESPNSITIMGLSTSRVAITLKPQDPMEQNVADLL-----
-------QFLLVKDQSKYPIR-VSEMR--QHIAKEYR-----SQFPEILRRAAAQ-----
----LECIFRFE---------LRE-LDPEA---------RTYI-----------------
-------L----------------------------------LNKLGPVPFE-----GLE
----ESPNGPKMGLL-------MMILGQILLSGNQ------AKEA---EIWEMLWRM---
-----GVQ-RER----RLSIFGNPKRLLSVEFVWQ------RYLDYRPL-TDCDPVEYEF
----YWGPRSHLETT--KMKILKFMARIYNKDPM----D-WPEQYNE---ALEEDAARAV
ADG---------------------------------------------------------
------------------------------------------------------------
----WQALPHFRRPFFEE----------VVAD------------------MPF-LD----
-SE---------------------------------------------------------
---------ASNY-------------------------S---------------------
---------SKYPPH-SWPESRL---ESKARKLVQ------LFLLMD-STKLPI--PK--
------------------------------------------------------------
----KGI---LYYIGRECSKVFPDLLNRAARTLNLVYGTELVVLDPRNHSYT-LYNRREM
EDTEEI-MDSPNR-PGNN---FLM----------QVLSF----------IF--------I
-TGNH----A-R--ESAVWAFLRGLGVQ--SGRKHVI--------TCRYLSQR-------
---------YIDSLRVPDTDP---V--QYEFVWGPRARLETSKMKALRYVARIHRR---D
------PQDWPEQYREAMEDEANRADVGHR-QF----------FVHNF------------
------------------------------------------------------------
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-----------------------------------------------------MSEQSKD
LSD---------------------------------------------------------
------------------------------------------------------------
--------PNF----------------------------A---------------AEV-P
DCEM--------------------------QDS-----------------DAVPVG---I
P--PPASLAAN----------LAGPPCAPEGP------------M---------------
----AAQQAS--------------------------------------------------
------PPP--------------EERIEDVD---------PKIL-QQA-A-EE--GR---
----------------------AHQPQ--SPARP--I-PAPPAPAQLVQKAHELM-----
-------WYVLVKDQKRMVLW-FPDMV--KEVMGSYK-----KWCRSILRRTSVI-----
----LARVFGLH---------LRL-TNLHT---------MEFA-----------------
-------L----------------------------------VKALSPEELD-----RVA
----LNNRMPMTGLL-------LMILSLIYVKGRG------AREG---AVWNVLRIL---
-----GLR-PWK----KHSTFGDVRKIITEEFVQQ------NYLKYQRV-PHIEPPEYEF
----FWGSRANREIT--KMQIMEFLARVFKKDPQ----A-WPSRYRE---ALEQARALRE
ANLAA----------------------------------QAPRSSVSED-----------
------------------------------------------------------------
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--------------------------------------MEPTE-----------------
-----------------NNQ-NFNLW-D----------------IPQA----QTE-ERG-
-------------PGSTQDP----------------------------------------
------------------------------------------------------------
--------------------------------------IAEA------------------
------------------------------------------------------------
---EEVEAIATA----PGD--V--------------------------------------
----------P--------------------------------------AGGT---PSSP
QSAQRAPS---PPTAMG-S--IS-----------------------------GASFE---
------------N------PLSEVP------------DAESPSQGGLNEKIIDLV-----
-------RFLLVKFRRMELTN-KEEMI--VKTMGDYE-----EHYSEIFSKAAEC-----
----MKLIFGVD---------MLE-VDPFV---------HSYF-----------------
-------L----------------------------------HPALGI-TYD----GM--
LH-GV-IGVPKTGLV-------ILVLCVIFIENNC------VREE---VFWHAMNIL---
-----GMQ-AGI----DHFIFGEPRSLITEDFVEE------GYVEYRQV-PNSNPPCFEF
----LWGARAYAETT--KMKILEFYASIVRQDPR----S-YPEKYAE---ALREEQERA-
------------------------------------------------------------
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---------------------M-------PQGNKGKRRTRKKH------QKT------SN
-PT---------------------------------------------------------
-----------------QDPADAQ------------------------------------
-----------------------------------------------------------A
-PE---------------------------------------------------------
-----------------------------------------------------------G
V--QQGEWSHH-------------LSPDFVGA------------LPSSPAHA--------
--------------------------------------------------QQG------S
----------LRGRPLGTP-GPGVPSNSEGA---------------KGRD-EA-------
---------SSX----X--XXXX--XXX-XXXXXXXX---XX------------------
------------------------------------------------------------
----XXXXXXXX---------XXX-XX------------XXXX-----------------
----------------------X-------------------XXX-----XX----XXX-
------------------------------------------------------------
-------------------------XXXXXXXXXX-------X-----X-XX------XX
----XXXXXXXX--XXXXX-----------------------------------------
------------------------------------------------------------
--------------------------X-------------------------------XX
X-----------------------X---XX----------------XXXXXXX-------
------------------------XX--X-XXX------------XXXXXXXXX------
---------------------------------------------------------XX-
XX---X--------X-XX------XXXXXXXXXXX------XXXXXX---XX-X--X---
------------------------------------------------------------
-----XX---XXXXX-------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-LVNKLSL
SSEDSL-TGERSL-PKTG---LVM----------TLLAV----------IF--------M
-KGSR----A-S--EEEMWQFLSSMGVY--AGRNHPIYGEPKKFLTQDLVEEQ-------
---------YLEYRQVPHRRP---P--AYEFLWGPKAYAETSKMEVLEMLAKINDT---A
------PYCFPVLYEEALR-----------DQQERAELCAV-------------------
------------------------------------------------------------
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--------------------------------------MSQD-Q----------------
-----------------ERL-QYAHY-Q----------------QLHS----FSE-SQD-
-------------LEVSQISQALE------------------------------------
-----------------------------------------------------------V
T-----------------------------------------------------------
------------------------------------------------------------
---FLSSSHSIM----SDN--MKEA---S---------------------PSK-------
----------K--------------------------------------TSTP-------
DSPQSFCS---SSIANA-V--TSSNKPDE----------------ISSSQ-DEEDVP---
------------S------ISQAVS------------DPENVPMDALDKKVALLV-----
-------NFMLLKYQTKESIR-KEDML--KMVIREDE-----DHFSEIFLRATER-----
----MEMIFGLD---------VKE-VDSIS---------HCYG-----------------
-------L----------------------------------FIKLGL-TYD----GML-
---GE-DSQPKTGLL-------ILILGVIFMKGNR------ATEE---EIWEVLNLM---
-----GIY-SGR----KHFIFGDVKKFITKELVKE------KYLEYRKV-ANNDIAQYEF
----LWGPRTYAETS--KMRVLEFLAKLHGTDLS----A-FPSQYKE---ALKDEGERAQ
ARNSIRDDSTS-------------------------------------------------
------------------------------------------------------------
-----------------------MG--------I----------------ASS----AA-
------------------------------------------------------------
---------VSS---------------------NFSR-----------------------
------------------I-----------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
--------------------------------------MPRGQK---SKLRAREKR-RKA
-RD-----ETRGL-----------------------------------------------
-NV-------------PQVTEAEE------------------------------------
-----------------------------------------------------------E
-EAP-------------------------CCSSS-----V---------------SGGAA
SSSP-A-------------------------AGI----------------PQEPQR---A
P---TTAAAAAA------------------------------------------------
------------------------------------------------------------
----------------GVS----STKSKKGA---------------KSHQ-GE-KNA---
-----------------------------SS-SQASTSTKSPSEDPLTRKSGSLV-----
-------QFLLYKYKIKKSVT-KGEML--KIVGKRFR-----EHFPEILKKASEG-----
----LSVVFGLE---------LNK-VNPNG---------HTYT-----------------
-------F----------------------------------IDKVDL-TDE---ESL-L
----SSWDFPRRKLL-------MPLLGVIFLNGNS------ATEE---EIWEFLNML---
-----GVY-DGE----EHSVFGEPWKLITKDLVQE------KYLEYKQV-PSSDPPRFQF
----LWGPRAYAETS--KMKVLEFLAKVNGTTPC----A-FPTHYEE---ALKDEEKAGV
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
--------------------------------------MPRGQK---SKLRAREKR-HQA
-RC-----ENQDL-----------------------------------------------
-GA-------------TQATVAE-------------------------------------
------------------------------------------------------------
GESP-------------------------SSAYL-----L---------------FGDRP
QNLP-A------------------------AETPS-------I-------PEALQG---A
P--STTNAIA-P------------------------------------------------
------------------------------------------------------------
-----------------VS----CS-SNEGA---------------SS-Q-DE-KSL---
------------------------------G-S--SREAEGWKENPLNKKVVSLV-----
-------HFLLQKYETKEPIT-KGDMI--KFVIRKDK-----CHFNEILKRASEH-----
----MELALGVD---------LKE-VDPIR---------HYYA-----------------
-------F----------------------------------FSKLDL-TYN----ETTS
----DEEKIPKTGLL-------MIALGVIFLNGNR------APEE---AVWEIMNMM---
-----GVY-ADR----KHFLYGDPRKVMTKDLVQL------KYLEYQQV-PNSDPPRYEF
----LWGPRAHAETS--KMKVLEFVAKMHDTVPS----A-FPSCYEE---ALRDEEQRTQ
AR-AAARAHTA-AM----------------------------------------------
----------------------------------------------------------AN
--------------------ARS--R-----------------------TTSS-SFSHAK
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
---------------------M-------SLVSQNARQ----------------------
------------------------------------------------------------
------------------SSAETT------------------------------------
-----------------------------------------------------------A
-DY---------------------------------------------------------
-----------------------------------------------------------S
D--SQGEMQA----------------TNASGP------------A-T-------------
---------------------------------------------------SM------L
----------ALEAPQ----GPEIPNDPQGA---------------SASQ-AV-------
---------RDP----S--DIEV--LID-EQSRRLGA---LRVHDPLEERSVALV-----
-------NFMRMKSQNEGSIR--QSEM--LEFLKEYS-----DQFPEILRRASAH-----
----LDRVFGLN---------LRV-LDPQM---------DTYN-----------------
----------------------L-------------------ISKPGP-QTT----ERLA
----ETLDIPKAGLL-------ALVLGHILLNGNR------AREA---SIWDLLLKV---
-----DVI---DGSQRINNQFGNTRNLLTIDFVHM------RFLEYWPV-YGTNPLEFEF
----LWGSRAHR--EITKM-----------------------------------------
------------------------------------------------------------
--------------------------E-------------------------------AL
K-----------------------F---VA----------------EAHDEEP-------
------------------------WSWPE-EYN------------KALEADKAKER---S
---------------------------------------------------------QA-
AG---L--------E-FWSED---TMNDKANELVQ------LAIGVT-EELLPI--HQ--
------------------------------------------------------------
----DEL---FANTGKEFQDVFPNILSRATLILDLFYGFSLIEVDTSEHIYL-LVPQPES
EEEQVM-LESLGR-PTQE---YLM----------PILGL----------IF--------L
-MGNR----V-K--EAKIWNLLQRFSVD--VGRKHAI--------TCKLMRQR-------
---------YLECRPLSYSNP---V--EYELLWGPRAHHEITKMKALEYMARFYGK---Q
------PQDWPEQYREAVE-----------DEEARARSEATAMFF----FGS--------
---I--------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
-------------------------------MPE----L-L-MHYHF-----------LS
F-RCPKHM-------LFCPDTCLLSQTTVIMPQ---------------------------
----------------------SKKNK-------------------------------PL
--------------------TPKKAS-HVQREAPR---LQEAQA--SKKKILP-SSSPP-
----------------------LGIISHT-KSTYQSRCPPKRSQ-R-------------A
---------V-ST---T-------------MSSDISTPRSDKG-------------ATCK
SKKKQHSSQPPKSII-QIPRDVL---TKMASRLVN------FIIRKY-KMKRLI--SK--
------------------------------------------------------------
----EGM---LKIIYKKYKNHFLEILRKASFNIEVVFGMDLKETDAISHSYT-LVDKMNL
PYNGKL-SRGRGF-PKTG---LLM----------NLLGV----------IF--------M
-KGNS----V-T--EEKIWEFLNKMRIY--DGQRHFLFGEPRKLITGDLVKLR-------
---------YLEYRQVPDSDP---P--LYEFLWGPRAYAETSKMKVLEFWAKINDT---T
------PTAFQGRYEEALRDEEERAKK---------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------MSQ--LSKNLGDSSPPAEAPRLP-------------------
----------VYSRPTVLMRAP-----PASSRAPPVPWDPPPMDLQAASLPAWQAPQPAW
EAPQGQLPAPV---APLAQPPGLGGPLVQAPPLGGPMGKPPT------------------
---------------PGVLMVHHPPPPGAPMPQPPTPGVLMVHPS--GAPIAHPPP-PGT
PLA-----------------------------------R---------------------
-----P---------P------------------PPGTPM----A-------HPPPPGTP
------------------------MGHP--PPPGTPMAHPPPLGTPMVHPPPPGTPMAHP
PPPGTP--MA-------------------HPPPPGTPMAQP---PAPGVLMAQPLTPGVL
MVQPP-------------APGAPMPQPL---PPAALM-------------------TQPP
PSAASMAKPPGPSVLMMHPSASGAPITQPPVSG---------------APMGQPMAP---
----PAQPMASWGPQGQPVILQIQSQVI----R-------APPQV---P-----------
-------Q---GPQTPQVQLATTPGWQATSPGWQAPPQGWQATPLTWQTTQVT-------
------------WQAPPPM-RQGPPPIRR-------------GPPPIRPGPPPV------
------------------------------------------ARQVPSVTRQAPPVIRQV
-PP---------V-----------------------------------------------
--------IRQAPPLIRQAPP-PI------------------------------------
-----------------------------------------------------------R
--------------SGPQILATQPQLWQALPPPP-----P---------------LRQAP
QARLLAPQVQG------------APQVPTGPIVTQ-------VPAAPPAGPQVPQP---V
L--QAPLSVP----------------------------------------LPGPLP----
-GPQAAPSAVPRVPQ-------QAVH--CPSIIWQAPKGQALVPHE--------------
------------------------------------------------------------
------------------------------------------------------------
---------RPTSMEFQEVQQ-AQ-AL--AWQAPKAP-----THFWQPLPAQEAQGQ---
----PPRIFQLE-----Q-QPFRGALASQKGPQTQL-SPHQAQPM--GPQTEMPTMQLQP
SWQGPPPMLQTQPGAPVVGANFPRGQPKSLMTP-SGECRASSSEPKGSS-RE----RRTS
TK--EKKGPSKDRM----------IFAGTFYSPRA----VSVSRAHLPNAWKNLRATSDT
FSATSRVF-PST----SHFQPASSNAFTGPSATSE----SPKSLPFAL---QDPYACVDA
LPAVPWVPHPNGNVSKASKAEPKILM-ATAPSPQ----A-TATV-PE---TSNT-VEPPR
RS-----------------------GKV--------------------------------
--TRK-----KKHLEPEE-DKRGHRMA-------------------------------SQ
--N-WQGS----QLWGNSS--LSDW--EIQSSLQ-V--LGDWGCPSTSFGTNGWESSSMS
-RV---------------LSG---WEGPSTSWAQDPWEGPSTSR-G--------------
---------LGHC---------------EGSGSPQPFMASDVP-------------C---
LSHRLRATQENLRGE-TQQLSAL---DERANALVQ------FLLVRN-QTKVPI--QD--
------------------------------------------------------------
----SET---VNVITREYEDQCLDIISHANRKLTCNFGCQLNEIDTRTRSYI-IINKLGH
PQCDLL-ASFIDR-PKFG---LLM----------VVLSL----------IF--------M
-KGNC----V-R--ENLIFNLLFRLGLD--VRETNALFGNTKKLITEVFVRHK-------
---------YLEYRRIPCTEP---A--EYEFLWGPRAFLETSKMLVLRFLAKLHKR---D
------PQCWPFHYLEALAEFESEDSDEDE-PDV----SDDS-------DDP--------
---TSSAPPH--------------------------------------------------
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----------------------------------------FPQ-----------------
-----------------KNP-QCSP-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------D
QLLQTH---------------------------------------RETQGLEVAQESKVL
EEACLS-SHPEM----PGN--LKE------------------------------------
---------AP--------------------------------------DAGI---PSTS
ESAQSSCS---SSVVTT-V--SLSGKYGE----------------GSSSE-EEED-----
------------S------TLEADP------------DPRMCPLHAVDENVASLV-----
-------NFLLLTYQMTEIIP-----K--KIVSKKSE-----DYFTEMFLRASER-----
----MEIIFGLD---------VKE-VDPTN---------HCYT-----------------
-------I----------------------------------FIDLGL-TYD----GI--
QH-GE-VGVPKTGIL-------ILILALIFMKGNR------ATEE---DIWDVLKVT---
-----GVY-SGR----KYHIFGEPRKLITKYFVKE------EYLKYQQV-PNSDPAQFEF
----LWGPRAHAETT--KMQVLEFMAKVHGIDPS----C-FPSQYED---ALQDEKDRVQ
ARI---------------------------------------------------------
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--------------------------------------MPRRK-----------------
-----------------KSP-RCPP-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------D
QHLQTQ---------------------------------------SETQGLESAQVTKPV
EEALPSSSLLPM----SGN--LKE------------------------------------
---------AP--------------------------------------AAKL---LSAP
EGPQSFCS---SSGDNT-A--MSSSKSDE----------------DARSE-EEKKSL---
------------S------TVEATA------------NPENVPIDALDRKVAVLV-----
-------NFLLVKYRRKDLVR-KADIW--KMIIQDDE-----DHFHEIFLRACEH-----
----MEMIFGLD---------VKE-VDPTR---------YCYG-----------------
-------I----------------------------------SIKLGL-TYD----GM--
MH-PP-VGLPKTSLL-------ILILAEIFMNDNC------VSEE---EVWKVLSKL---
-----KIY-SGQ----MHFIYGHPKELVTKYLVME------KYLEYRQV-ANSDPARYEF
----LWGPRAHAEVR--KMEILEFLAKVHGTEPQ----S-YRSQYED---ALRDEEERAQ
ARNYSRLPLP--------------------------------------------------
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------STFS-T------------------------------------------------
------------------------------------------------------------
-----------------TS----DTTSDEED---------------TS-Q-DE-EDS---
-----------------------------RS-SDVSSSTENTYSDTLNSMTSLLE-----
-------EFLLHKYKMKQPIM-KEDML--MIIHPKYH-----NRFAEILKTASEH-----
----IEAVFAVD---------LKE-VDSTI---------HSYD-----------------
-------L----------------------------------VSKLNL-PNN----GRVW
----DGRGLPKTGLL-------MTVLGVIFVKGNC------AAEE---DIWKFLNMM---
-----RVY-AGR----KHFIYGEPRKLITKDFVTM------KYLEYRQV-ANSDPPCYEF
----LWGPRAHVETS--KMKVLEFLAKVNDTVPG----A-FSSQYEE---ALRDEEESSS
HS-SSQAWH-H-SH----------------------------------------------
----------------------------------------------------------FQ
--------------------ACSMAR-----------------------SSC---FSYPY
------------------------------------------------------------
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--------------------------------------MPRGQK---SKLRAREKR-RQN
-RA-----EAQGL-----------------------------------------------
-KS-------------AQAATAEE------------------------------------
------------------------------------------------------------
-EAT-------------------------ASSPP-----V---------------TGDGA
SSSS-V-------------------------AGS----------------LQAPAR---V
S--AAASAAA--------------------------------------------------
------------------------------------------------------------
----------------GVS----CRRSDVRA---------------KS-R-VQKSEN---
--------------------------------PQAAPSSESSGHDLLTRKAGMLM-----
-------HFLLCKYKMNEPIK-KGDML--KVIHKRYR-----EHFPEILKKASER-----
----MDLVFGLE---------LKE-VKPNG---------HSYS-----------------
-------L----------------------------------VCKLDD-SRD----ESTS
----NALRFPTKVIL-------MPLLGLIFLNGNR------ASEE---EIWELLNIL---
-----GVY-DEE----THFILGEPRDIITQNLVQE------KYLEYRQV-PGSDPPRFEF
----LWGPRAQAETT--KGKVLDFLCKVNDTFPT----D-FPPHYEE---LLRGEKERAR
ATAA-TMA----------------------------------------------------
-----------------------------------------------------------G
--------------------ATDKA------------------------------RA---
------------------------------------------------------------
------------R-----------------------------------------------
------------------SRATS---S-RDPPHE--------------------------
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--------------------------------------MPRGHK---SKLRACEKR-QQA
-RG-----ETQGL-----------------------------------------------
-QD-------------AQATTAAE------------------------------------
-----------------------------------------------------------E
-EST-------------------------PSPSP-----Q---------------PGAVV
QSPPAA------------------------AGSCS-------T-------SQGPRR---A
P--ATTTASA-S------------------------------------------------
------------------------------------------------------------
-----------------VS----YTTSGKAS---------------DS-Q-DE-ARA---
-----------------------------ST-PKAQPSTESSGLDSLSKKAVLLE-----
-------QYLLYKYKMKQPAM-KADML--KIINPNYE-----DRFAEILKKASEH-----
----IEAVFALE---------LKE-VDLPS---------RSYD-----------------
-------L----------------------------------VSKLKL-PNN----GRVR
----GGRGLPKTGLL-------MNILGMIFIKGNC------ASEE---DIWKFLSMM---
-----QVY-AGR----KHYIYGEPRKLITKDLVRL------QYLESRQV-PNSDPPRYEF
----LWGPKAHAETS--KMEVLKFMAKISDTVPS----A-FPCYYEE---ALQDEEEKAR
AI-DAARAT-A-K-----------------------------------------------
------------------------------------------------------------
--------------------VCAPSG-----------------------AV----PSNIY
PPL---------------LKS-E-------------------------------------
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--------------------------------------MPRGQK---SKLRARAKR-RQA
-RQ-----EPSDL-----------------------------------------------
-VE-------------AQPTEPEE------------------------------------
-----------------------------------------------------------E
-EFP-------------------------SSPSP-----S---------------FEDVP
QSSA-A------------------------TGTSS-------S-------LQVPGK---V
C--STTTVAA-S------------------------------------------------
------------------------------------------------------------
-----------------VS----DAKFSEGA---------------TD-Q-GK-ERP---
-----------------------------KV-SQSKDTTEQSSKDLVDEKVPLLV-----
-------NYLLYKYQMKEPVT-KRDML--RKVIHKHK-----NLFSEILKKASEH-----
----LELLFGLD---------VKE-TDPNR---------GIYV-----------------
-------L----------------------------------VNKLEL-GCD----EKTG
----NDREIPKTGLL-------MIVLGVILTKGNC------ATEE---QVWKVLNLM---
-----ELY-EEK----KDRIYGDVKRLITKDLVQK------KYLEYRQV-ANSDPPVYEF
----LWGPRAYSETT--KMKVLEFVARIHGKVPA----A-FPSLYEE---ALKDEEERAQ
AR-ASARARTA-AL----------------------------------------------
----------------------------------------------------------AR
--------------------ART--W-----------------------AKAH-SSSSTK
------------------------------------------------------------
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--------------------------------------MPRGQK---SKHRAREKR-RQV
-RS-----DTHSV-----------------------------------------------
-KG-------------AQATAAEE------------------------------------
-----------------------------------------------------------E
-GSP-------------------------SSSSP-----P---------------SRDSP
ESSP-A------------------------AAGI----------------PQEPPR---V
Q--PI-TTAAVR--AASGTGASGGAEGQYEGR------------SSPSEAPAPSERSQRD
PVTRREVDT--TG---------QSY--------TIVSKLEITNSGSLQAEVAS-----PQ
GAPRPPPTT---TAAAGAS----GRRAPRGA---------------KG-Q-GE----G--
----------GP-----------------RS-SSALAPNERSRRDPLTRRVTMLS-----
-------QFLLSKYEKQERIM-KGKMM--KIINKRYK-----EQFPEILRGSSEH-----
----IEMVFGLD---------VKE-VDSKG---------QSYS-----------------
-------L----------------------------------VSKLEI-TEE----ENLN
----GGRGFPKKGLL-------MPLLAMISMNGNR------ATEE---EMWEFLNMV---
-----GMY-DGK----THFIFGEPRKLITKDLVQA------KYLEYRQV-PNSDPPCYQF
----LWGPRAQAKAS--KTKVLEFLAKGNNTCSS----A-FQPLYEE---TCRDEEKRAT
GREC--------------------------------------------------------
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---------SP--------------------------------------QGPP---QSPP
RSPLNSCS--------S-P--LLWTRLDE----------------ESSSE-EEED-T---
------------A------TWQAL------------PESESLPRC-----VAELM-----
-------QFLLLKYQKKEPVP-KAEML--TTVIKKYS-----DYFPMVFGKAHEL-----
----MELIFGIA---------LTD-MDPDN---------HSYF-----------------
-------F----------------------------------EDTLDL-TYE----GS--
LI-DD-QGMPQNCLL-------ILILSMISIKGSC------VPEE---VLWEVLSAI---
-----GVC---------HFIYGNPRKLLTIDWVQR------KYLEYWEV-PNNAPPRYEF
----LWGPRAHSEKS--PRVFSQAIQY----HP---------------------------
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--------------------------------------MPRGQK---SKLRAREKR-RQA
-RA-----KNAQ------------------------------------------------
--E-------------EEASPGPF------------------------------------
-----------------------------------------------------------Y
-GCP-------------------------H------------------------------
QAIP-V-------------------------ASM----------------PTSPNM---P
M--GE-------------------------------------------------------
------------------------------------------------------------
--------------QSTFS----HSYTSTSD---------------QN-L-DE-------
-----------------------------KS-SDDSQDTEDWCKDPINHKVVLLV-----
-------QFLMEKYQKKEVIT-KADML--KYVIKTSK-----NHFNEILKRASEH-----
----MELAFGID---------LKE-VDPNR---------HCYA-----------------
-------L----------------------------------FNKLEH-TFD----GVMG
----E-EKMPSSGLL-------MIVLGVIFMNDNC------VSET---EIWNVLSMM---
-----GVY-ANR----KHFIYGDPKKVITEDMVQL------KYLEYQQV-PNSNPPSFEF
----TWGPRACAEIS--KMKILEFWAKIHDTTPD----S-FPTLYEA---ALKDEEERAQ
ARAV-ARA----------------------------------------------------
-----------------------------------------------------------H
--------------------TAAMA------------------------------SP---
------------------------------------------------------------
------------Y-----------------------------------------------
------------------SRATV---CSSS--HTN------I------------------
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------------------------------MPR---------------------------
----------------------GQKNK-------------------------------HH
RNRLKNKKHNQEKVHPQKDESQEKGH-HKRDDFQD---HKEAR-DNAAVEEKS-SCSSP-
-SV-------------------PGE-TLE-KPPASKTSS------D------------A G
---------WLSC---V-------------SSPATVC-GDELE---------FDDGTYCH
CGGNSLYSEYRTCQE-NPCKHCL---DMYVNLVEQ------YVLYKF-KMKKLI--DR--
------------------------------------------------------------
----NEL---IDLIEPKYRYNFSDIFKRAFENIEIVFAASVIEIDSTNHVYD-LVSKLKL
PNKGRV-CPGRGL-PKTG---LLM----------TILAM----------IF--------M
-NGNS----A-S--EEDIWKFLNYMQVY--PGRKHFIYREPRKLITQDFVKLK-------
---------YLEYKQVSLSDP---P--CYRFQWGPKAYTETTKMKVLEFMAKGSGI---E
------PSTFSVQYAEALREENQKAKIRKW-YP---------ILA----QKHCPGHSH--
QHVQKVMKPQ--------------------------------------------------
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---------------------------------------------------MKTQLSRLG
WGPSLPGVKGRKKREEHG--GLGIQVSVSLHPED---P---LIPLLGAPG----------
---------TWRSCLISLQILRG----------QADQE---DRNPT-EVSH---------
----------TLPLFPDLWIPITQLLPTLPSAALTRVIMPLGQ-----------------
-----------------RSQ-HYMPE-E----------------GREA----QGE-TPG-
-------------LVGGQDPVPEE------------------------------------
-----------------------------------------------------------E
E-A---------------------------------------------------------
------------------------------------------------------------
---A-SSSSSPI----MGT--LE-------------------------------------
---------LC--------------------------------------APGA---LSPP
QSMQGASS---SPTTID-N--TLGSQSDE----------------GSSN--QEKKEP---
------------I------TLPSPS------------VMESLS-EKHSDKVSDLV-----
-------SVLLHKFQIKESIT-KPEMV--DSVIKNYK-----DYFPFIFKESSEY-----
----MQLIFGID---------VKG-VVPPG---------HSYV-----------------
-------L----------------------------------VTSLGL-SYD----GMLV
---DD-LSKPKTDLL-------VIVLCVIYMEGNC------APEE---VMWEALNVI---
-----EVY-AGW----EHFIYGEPRKLLTQDWVQE------NYLEYWQV-PRSDPACYEF
----LWGPRAHAETS--KKKVLEYVTKISGRELT----S-YPFLYEE---DLREEEERV-
------------------------------------------------------------
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--------------------------------------AEGWSPGPLNKKVAEAV-----
-------QFLSVKYITKEPVT-KAEML--KSIIREHQ-----GHFPAIFRKVCEC-----
----MEVVFGIE---------VKE-VDPTS---------HSYV-----------------
-------L----------------------------------IKTLDL-TYD----GMLT
---D-DQGMPKTGLL-------ILILGVIFIEGNR------GPEK---RIWEVLNMI---
-----EVY-AGR----KDFIYGEPRKLITKDLVQE------KYLEYWQM-PNSNTPCYKF
----LWGPRAHAETS--KRKVLEFFAKVSGADPT----S-FQSWYEE---ALRDEKERAQ
TKVATTDGTTA-------------------------------------------------
------------------------------------------------------------
-----------------------IA--------S----------------ESS----SV-
------------------------------------------------------------
---------TSS---------------------GFS------------------------
------------------------------------------------------------
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--------------------------------------MADFH-----------------
-----------------NTQ-YCNLQ-E----------------SAQA----QQE-----
-------------LDNDQET----------------------------------------
------------------------------------------------------------
--------------------------------------METS------------------
------------------------------------------------------------
---EEEE-DTTT----SNK--V--------------------------------------
----------Y--------------------------------------GSGI---PSPP
QSPQRAYS---PCVALA-S--IPDS------------------------P-SEEASI---
------------K------GSEGLE------------DPLYLLHNAQNTKVYDLV-----
-------DFLVLKYQMKAFTT-KAEML--ESIGREYE-----EYYPLIFSEASEC-----
----LKMVFGLD---------MVE-IDPSV---------HSYI-----------------
-------L----------------------------------VTALGI-TYD----GM--
MT-DV-QGMPKTGIL-------IAVLSVIFMKGNY------VSEE---IIWEMLNNI---
-----GLY-GGR----NPYIHKDPRKLISEEFVQE------GYLEYRQV-PNSDPPSYGF
----LWGPRAFAETS--KMKVLQFFASINKTHPR----A-YPEKYAE---ALQDEIDRTK
AWILNRCSNSS-------------------------------------------------
------------------------------------------------------------
-----------------------DL-------------------------LT---F----
------------------------------------------------------------
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------------------------------MPR---------------------------
----------------------GNKSK---------------------------------
-SR-----------------SRAKRQ-QARGESQN---LQGAKPTSEKE--------AA-
-SP-------------------TLG-QGD-APSSPDICTPQGSQ-E-------------A
---------ASHG---S-------------PELNVSHSVSNVS---------AEGSVAGV
DVKRSNACIIAEAID-SARRDPL---SRKASKILH------YLLEKY-QKDEQP--VE--
------------------------------------------------------------
----AEM---LKLINRKYKVHFPWILEKATYQLEMVYGLELKVDH--THSYV-LVNKLPI
PPGAKQ-GGKKEL-PKTG---LIL----------TLLGM----------IM--------M
-KGNR----A-T--EEEVWQFLHMQGIY--PGRRHLIFGEPRKFITKELVEQN-------
---------YVEYRQVPGSHP---P--TYEFLWGSRAHDETIKAKVLDVLAKIKNA---I
------PGFYPQQYEEALSNQAERAARRGE-ASGHHGA---RIPS----HAQSSSSSHT-
------------------------------------------------------------
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------------------------------------------------------------
--------------------------------------------------------MAE-
----------------------------------------------------------GS
FG-----V-Q-------SENYSVEDMDEGSDEVG--EEEMVEGNDYE----EFGAFGGYG
TLTSFDIHI--LRAFGSLG-----------------------------PGLRILSNEPWE
LENP-VLAQTLV-------EALQ--LDPETLANETAARAA-------------NVARAAA
---S----------NRA-ARAA--------------------AAAARSAFNQV---MASH
R-------------------------------------------------VAT-------
------PQVSGEDTQPSTYAA--EAQ--------------------GPSPEPPLASPQTS
------QMLVTSEMAAPGALAT-SAQSQTGS---------------PAQ-----------
-------------EAA----------------TEGPSSACAFSRAPSASEVD-ATRPSTA
FLGP----------------------------NDVFD-------FTQPAGV---------
----SGMAFPRPKRPAPAQEA--ATEGPSA---------AS-GVSQTGPGREMAATRPKT
T-----------------------------K-----------------------------
------------------------------------------------------------
--------------------------------------------------------SGKA
LAKTRWVEPQNVVAAA--------AAKA-KMATS---------IPEPEGAAA--ATAQHS
AE-----------------------P---------------------------------W
ARMGGKRTKKSKHLDDEY--------ESSE-EEREPPAVPPTWRASPPSLT---------
---------V----R---------------------------------------------
----------------------------------------AQLA----------------
-----------------PRPP-----------------------------A----A----
-PRSQIPSRHVLCLP-PRNVTLL---QERANKLVK------YLMIKD-YKKIPI--KR--
------------------------------------------------------------
----SDM---LKDVIREYDEHFPEIIERATYTLEKKFGIHLKEIDKEEHLYI-LVCTRDS
SAR-LL-GKTKDT-PRLS---LLL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPFLGDLRKLITDDFVKQKNPGLTEG
APLSGAHSWYLEYKKIPNSNP---P--EYEFLWGLRARHETSKMRVLRFIAQNQNR---D
------PREWKARFLEAVDDAFKKMDVDMA--EEHAR----AQMRAQMNIGDEAL-----
------IGR--WSWDDIQVELLT-WDEDGDFGDAWA-RIPF----AFWARYHQYILNSNR
ANRRA------TWRAGVSSGTNGGASTSVLDGPSTS-ST---IRTRNAARAG--------
----ASFFSWIQHR----------------------------------------------
------------------------------------------------------------
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--------------------------------------MSLS-Q----------------
-----------------KSE-CCKLE-E----------------DLQA----SRE-AQG-
-------------PVGVQGPVAEE------------------------------------
-----------------------------------------------------------E
E-AT--------------------------------------------------------
------------------------------------------------------------
--STSFSLYPLI----PGT--PGEA---P---------------------ATG-------
----------T--------------------------------------LSPL-------
QSSQTACL---SPTAVT-T--VPSSQSDE----------------S-SRS-QEEEGL---
------------ST------SQSPS------------DPESLLTDVLDKNIADLL-----
-------QFLSVKYITKEPIT-KAEML--KTIIREHQ-----GHFPVIFRKVCER-----
----MEVVFGIE---------VKE-VDPTS---------HSYV-----------------
-------L----------------------------------VRALDL-TYD----GLLS
---D-EQGVPKTGLL-------ILILGVIIMKGDC------APEE---KIWEVLSMM---
-----GVY-AGR----KDFIYGDPRKLITKDFVQE------KYLEYRQV-PNSDPPHYEF
----LWGPRAHAETS--KRRVLEFFAKISGTDPS----S-FPSWYKE---ALRDEKEKA-
------------------------------------------------------------
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--------------------------------------MRRG-E----------------
-----------------RSQ-HRELE-E----------------ALQA----QGE-APG-
-------------PAAGQAPAAEE------------------------------------
-----------------------------------------------------------E
E-AG-----------------------TASLSA---------------------------
------------------------------------------------------------
-------APALI----PGT--ADEV--LA---------------------A-G-------
--------------------------------------------------S-----PS--
--PQEASS---LLSTIA-F--ILCSQSDE----------------S--------------
-----------------------SS------------GPGSLLQETLGEKIAHLV-----
-------YFLLHKYRNKEPLT-KAEML--SAVIKSEE-----EHFPAIFEEASEC-----
----MRLVFGIE---------VKE-ADPTG---------HSYV-----------------
-------L----------------------------------APSLGL-SYD----GMLG
---DD-QSKPKTGLL-------ITVLGTIFMAGDC------ASEE---IMWESLSVL---
-----GVW-PGR----EHCMYGEPRKLLTQDWVQE------AYLEYRRV-PGSDPARYEF
----LWGPRAHAETS--KMKVLEHVAKVSGRDAA----S-YPSLYEE---GEG-------
------------------------------------------------------------
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--------------------------------------------------MLQKPE---S
G--------------------------------------------------GLPVP----
-------QAK----------------------------GEKDGGHDGEPQALT-----A-
-SQE-------------------SPKEDLRS---------------VREE-G--------
----------------SAEPALTRKGA--RA-LAARALARRRAYRRLNRTVAELV-----
-------QFLLVKDKKKSPIT-RSEMV--KYVIGDLK-----ALFPEIIARAAEH-----
----LRYVFGFR---------LKQ-FDRKH---------HTYI-----------------
-------L----------------------------------INKLKPLEEE--------
EKEDLGGDGPKLGLL-------MMILGLIYMKGNS------AREA---QVWEMLRRL---
-----GVH-PSK----YHFLFGYPKRLIMEDFVQQ------RYLNYRRQ-PHSNPPEYEF
----SWGPRSNLEIS--KMKVLGFVAKLHKKEPQ----H-WPAQYGE---ALADEADRAR
AKAR-AEASMRARA--------RANA------R---------------------------
------------------------------------------------------------
-AT----V------H---------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
-----------------------------------------------------VGKKVKD
LGY---------------------------------------------------------
------------------------------------------------------------
--------SRF----------------------------A---------------AEA-S
HAEV--------------------------CIS-----------------PGVPME---G
P--PPASQAAT----------LGEPQSLPFSP------------M---------------
----DAPQAS--------------------------------------------------
------PSP--------------QALSDEGD---------MRAL-LLE-E-EE--DC---
----------------------ACQAQ--SAAQAQPG-LAPPTPAQLVQKAHELM-----
-------WYVLVKDQRKMVIW-FPDIV--KDVIGSYK-----KWCRSILKRTSII-----
----LARVFGLH---------LRL-TNLHT---------MEFS-----------------
-------L----------------------------------VKALEPEELD-----RMA
----LSNHMPMTGLL-------LMILSLIYVKGRG------ARES---AVWNVLRIL---
-----GLR-PWR----KHSTFADVRKVITEEFVQQ------NYLKYQRV-PYVEPPEYEF
----FWGPRACREIT--KMQIMEFLSRVFKKDPQ----A-WPSRYRE---ALQEARALRE
AETIA----------------------------------HAFRSSISED-----------
------------------------------------------------------------
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---------------------------------------MSDT-----------------
---------------SE-SGA----------------------------GLTSFQAEASE
KDSS-SMMQTLL-------TVTQ--NVEVPETPKAS------------------KA----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------PEVSEDVKVS-------KASGVS---------------KAT-----------
-------------EV---------------------------SKTPEAQEAP-ATQASST
-TQLTDTQVLAA----EN--KSLAADT--KKQNADPQ-------AVTMPAT---------
----ETKK-----VSR--------------------------------------------
------------------------------------------------------------
--------------------------------------------------------VA--
-------------------------------DMKV-------------------------
----N-T--KAQETEA--------AASQAPADEP---------EP--ESAAAQSQENQDT
RPKVK--------------------A---------------------------------K
KARKVKHLDGEEDGS---------------SDQSQASGTTGGRRVSKALMASMARRASRG
PIAFWARRAS----RTRLA----A------------------------------------
------------------------------------WARRALL----SLRSPKARRGKAR
RRA---------------------------------------------------------
-AKLQS-SQEPEAPP-PRDVALL---QGRANDLVK------YLLAKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LKDIIKEYTDVYPEIIERAGYSLEKVFGIQLKEIDKNDHLYI-LLSTLEP
TDAGIL-GTTKDS-PKLG---LLM----------VLLSI----------IF--------M
-NGNR----S-S--EAVIWEVLRKLGLR--PGIHHSLFGDVKKLITDEFVKQK-------
---------YLDYARVPNSNP---P--EYEFFWGLRSYYETSKMKVLKFACKVQKK---D
------PKEWAAQYREAMEADLKAAAEAAA--EAKAR----AEIRARMGIGLGSE-----
----NAAGP--CNWD-------------EADIGPWA-KARIQAGAEAKAKAQESG--SAS
TGASTST------NNSA--SA--SAST--SGGFSAGASLTATLTFGLFAGLGGAGASTSG
SSGACG-FSYK-------------------------------------------------
------------------------------------------------------------
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------------------------------------------

------------------------------------------------------------
-------MGDKDMPAAGMPSLLQSSSESPQSCPEGEDSQSPLQIPRSSPESDDTLDDTLY
PLQSPQSCSEGEDSSDPLQRPPEGKDSQ---SPLQIPQSSPEGDDTQSPLQNSQS-----
-SPEGKDS-----LSPL--------EISRSPPEGEDVQSPLQNPASSFFSSIPVSSSSSS
TLLSLFESSPERTQSTFEGF--PQSPLQIPVSPSFSSTLLSLFQSSPERTQSTFEGFAQS
PLQIPMTSSFSSTLLSIFQSSPESVQSTFEGFPQSPLQIPVSPSSSSTLLSLFQSSPERT
QSTFEGFPQSPLQI----------------------------------------------
------------------------------------------------------------
--------------------------------------------PVSRSFSSTLL----S
IFQSSPERGQRT---SEGFAQSPLQIPVSSSSSSTLLSLFQSSPERTQSTFEGFPQSPLQ
IPSPPQG-EDSLSP------DYFPQSPQG---EDSLSPHYFP-QSPQGEDSLSPDYFPQS
PPQGEDSLSPHYFPQSPPQGADSLSPHYFPQSP-QGEDSLSPHYFPQS-PQGEDSLSPHY
F--PQSPPQGEDSLSPHYFPQSPPQGEDSMSPLYFPQ-----SPLQWEEFQSSLQSPVSI
CSSSTPSSLPQSFPESPQSSPEG-PVQSPLYSPQSPPEGTHSQSPLQSPESAPEGEDSLS
PLQIPQ---SPLEGEDSLSSLQFPQSPP-------------------------------D
-P--PKWKDSMSPLHFP---QNPPQG-E----------------DFQSSLQSPVS-ICS-
-------------SS---------------TSLS-----------------LPQ------
---SFPESPQSP-----------------------------------PEGPAQSP--LQR
P-----------------------------VSSFFSYTLASLLQSSH----------ESP
Q--------------------------------------------SPPEGPAQSPLQSPV
SSFPSSTSSSLS----KSS--PES------------------------------------
----------------------------------------------------P---QSSL
QSPVSSFS--------S-S--TSLSPFSE----------------ESSSP-VDEY-T---
------------S------SSDTLLESDSLTDSESLIESEPLFTYTLDEKVDELA-----
-------RFLLLKYQGKQPIT-KAEML--TNVISRYT-----GYFPVIFRKAREF-----
----IEILFGIC---------LRE-VDPD----------DSYV-----------------
-------F----------------------------------VNTLDL-TSE----GS--
LS-DE-QGMPQNRLL-------ILILSIIFIKGTY------ASEE---VIWDVLSGI---
-----GVR-AGR----EHFAFGEPRELLTKVWVQE------HYLEYREV-PNSSPPRYEF
----LWGPRAHSEVI--KRKVVEFLAMLNNTVPI----T-FPSSYKY---ALKDVEERAQ
AIIDTTDDS-T-------------------------------------------------
------------------------------------------------------------
-----------------------AT------ESA----------------SSS--V----
------------------------------------------------------------
---------VSP---------------------SFSS-----------------------
------------------E-----------------------------------------
------------------------------------------------------------
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--------------------------------------------------MLQKPR---N
R--------------------------------------------------GRSSG----
-------QAE----------------------------RDRDWSHGGNPGASR-----AG
EDARVLRDGFAEE----------APSTSRGP---------------G-------------
------------------VAGPSPQGA--RR-AQA---------KQLELKVSELV-----
-------QFLLIKDQKKIPIK-RADIL--KHVIGDYK-----DIFPDLFKRAAER-----
----LQYVFGYK---------LVE-LEPKS---------NTYI-----------------
-------L----------------------------------INTLEPVEED----AEMR
----GDQGTPTTGLL-------MIVLGLIFMKGNT------IKET---EVWDFLRRL---
-----GVY-PTK----KHLIFGDPKKLITEDFVRQ------RYLEYRRI-PHTDPVDYEF
----QWGPRTNLETS--KMKVLKFVAKVHNQDPK----D-WPAQYCE---ALADEENRAR
PQPS-GPAPS--S-----------------------------------------------
------------------------------------------------------------
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------------------------------------------

------------------------------------------------------------
------------------MSL--VSQNSRRRRRRVAK---ATA-----------------
----------H-NSSWDEMQAPNAPGFPADMPGSDVPQGPSDSQILQ-GLCAS-------
---EG-----------------PST------------SVLPT------------------
---------------SAEGPST---------FVPPTIS---EVSSASGQPTV-SEG-PGT
SLLATP---------------S-EG----LSTSGPPIIS---------------------
-----KGLCTSVTLAASEGRN------TSRPPTSSEEPST---S----------------
--------------------------V-----------------------------TSVV
PTPDEGPSTS-------------------V------------------------------
--------------------TS---VP-----PTATEG------------LST---PVPP
T------PDEGPSTSMPATPGEGRSTSMLPAAS---------------DGQSIS------
------------------------------------------------------------
------------------------------------------LVPTPGKGSSTSGPPTAT
EGLSTSV---------QPTAGEGQSTSV--------------------------------
---------------------------------------------------------TSV
----------PPT----------------------------------------------P
SEGLSTS---------VPPTAT--------------------------------------
-----------------------------------------------------------E
GLST--------------------------SVPP-----T---------------PGEGP
ST-SVLP-TPG------E-GRS-TSVPPT-ASD-GS--D---T-SVP---PT-PSE----
G--PSTLVQP----------------TASDRP--------------GSSVLPNP------
---GEGPSTLFSCSA-----SVDRNPSKCS-IVLPSPRVTKA------------------
----------------S------VDSDSEGP---------------K-------------
-------GAEGPIEFEVLRDCESPNSITIMGLSTSRVAITLKPQDPMEQNVAELL-----
-------QFLLVKDQSKYPIR-ESEMR--EYIVKEYR-----NQFPEILRRAAAH-----
----LECIFRFE---------LRE-LDPEA---------HTYI-----------------
-------L----------------------------------LNKLGPVPFE-----GLE
----ESPNGPKMGLL-------MMILGQIFLNGNQ------AKEA---EIWEMLWRM---
-----GVQ-RER----RLSIFGNPKRLLSVEFVWQ------RYLDYRPV-TDCKPVEYEF
----FWGPRSHLETT--KMKILKFMAKIYNKDPM----D-WPEQYNE---ALEEDAARAF
AEG---------------------------------------------------------
------------------------------------------------------------
----WQALPHFRRPFFEE----------AAAE------------------VAS-PD----
-SE---------------------------------------------------------
---------VSSY-------------------------S---------------------
---------SKYAPH-SWPESRL---ESKARKLVQ------LFLLMD-STKLPI--PK--
------------------------------------------------------------
----KGI---LYYIGRECSKVFPDLLNRAARTLNHVYGTELVVLDPRNHSYT-LYNRREM
EETEEI-VDSPNR-PGNN---FLM----------QVLSF----------IF--------I
-MGNH----A-R--ESAVWAFLRGLGVQ--SGRKHVI--------TCRYLSQR-------
---------YIDSLRVPDSDP---V--QYEFVWGPRARLETSKMKALRYVARIHRK---E
------PQDWPQQYREAMEDEANRADVGHR-QF----------FVHNFR-----------
------------------------------------------------------------
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--------------------------------------MPRGQK---SKLRAREKR-DKA
-RG-----ETQGL-----------------------------------------------
-GG-------------AQASAAA-------------------------------------
------------------------------------------------------------
EEPP-------------------------SFTSN-----P---------------LGDIN
QNSP-A------------------------PGTPS-------T-------PKVPQG---V
H--SATTTSA-A------------------------------------------------
------------------------------------------------------------
-----------------IS----CTNSAEGA---------------NS-Q-DE-S-S---
------------------------------E-F--SQVAETLYKDPLNKKVVLLV-----
-------QFLLQKYQKREPIT-KADML--KFVIKKYK-----HHFNEILKRTSEH-----
----MELAFGVD---------LKE-VDPIR---------HYYA-----------------
-------L----------------------------------VSKLDF-SMD----GPLS
----DEENMPKTGLL-------MITLGVVFMRGNC------APEE---EIWEVLNMM---
-----GVY-AEK----KHLIYGDPKKVITEDLVQL------KYLEYRQV-LNSDPPRYEF
----LWGPRAHAETS--KMKVLEFWAKIHDTVPR----A-FPSWYEE---AVRDEEERAQ
AR-MAARARTA-AM----------------------------------------------
----------------------------------------------------------AS
--------------------ARF--R-----------------------AMSS-TLSRPS
------------------------------------------------------------
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----------MSPHP------FPSDG-K----------------DPQN----PGA-IED-
-------------S----------------------------------------------
-------------------------------------------------ADAEIP--SDE
EASS-------------------------MSS-SYTYLFPLSPS----------------
------------------------------------------------------------
------L-PSSP----SSD--EEEEGE---------------------------------
-----EREVGG--------------------------------------RGRG---ESPP
QNPISSSS--------S-S--ASWSPVSG----------------ESSSQ-KEED-P---
------------S------TCQGL------------SDSDSLFTNTLDEKVAEVV-----
-------QFLLLKYEAKEPVT-EAEML--MIVL-SYQ-----DYFPIILQKAREF-----
----MELLFGLA---------LIE-VDPD----------HLYA-----------------
-------F----------------------------------ANTVDP-TDK----GS--
-S-DD-QGMPKNSLL-------VLILSIIFIKDGC------ACEE---VIWEVLNAI---
-----GVY-AGR----EHFIYGEPRELLTKVWVQE------QYLEYRQV-PNTSPPYYDF
----LWGPRAHSESS--KRKVLEFLAKLNSTVPN----S-FPSWYKD---ALKNVGERAQ
AIISTKDDA-T-------------------------------------------------
------------------------------------------------------------
-----------------------DK------ASE----------------SLS--D----
------------------------------------------------------------
---------I--------------------------------------------------
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-------------------RAA--------------------AAAARTAFTQV---VASH
R-------------------------------------------------VAT-------
------PQVSGEDTQPTTYAA--EAQ--------------------RPTPEPPLASPQTS
------QMLVTSEMAAPGAAVT-STQSQAGS---------------PAQ-----------
-------------EAA----------------TEGPSRACAFSQAPCAREVD-TTRPSTA
FLGQ----------------------------NDVFD-------FTQPAGV---------
----SGMAFPRPKRPAPAQEA--ATEGPSA---------GS-GVPQTGPGREVAATRPKT
T-----------------------------K-----------------------------
------------------------------------------------------------
--------------------------------------------------------SGKA
LAKTRWVEPQNVVAAA--------AAKA-KMATS---------IPEPEGAAA--ATAQHS
AE-----------------------P---------------------------------W
ARMGGKRTKKSKHLDDEY--------ESSE-EEREPPAVPPTWRASQPSLT---------
---------V----P---------------------------------------------
----------------------------------------AQLA----------------
-----------------PRRP-----------------------------V----A----
-PRSQIPSRHVLCLP-PRNVTLL---QERANKLVK------YLMIKD-YKKIPI--KR--
------------------------------------------------------------
----ADM---LKDVIREYDEHFPEIIERATYTLEKKFGIHLKEIDKEEHLYI-LVCTRDS
SAR-LL-GKTKDT-PRLS---LLL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPFLGDLRKLITDDFVKQK-------
---------YLEYKKIPNSNP---P--EYEFLWGLRARHETSKMRVLRFIAQ--------
------------------------------------------------------------
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--------------------------------------MPRRHK---SKSHARRKR-HEV
-QG-----DTQEA-----------------------------------------------
-QA-------------SAAAAPKE------------------------------------
-----------------------------------------------------------E
-CP--------------------------SSHSS-----A---------------PQGSP
ASSP-A-------------------------AGD----------------GQELQG---A
M--APSSPDA-G------------------------------------------------
------------------------------------------------------------
-----------------PS----CAGSDEGA---------------QG-P-EE-ASA---
-----------------------------GA-SQAAPSTQSTRKDPLARKARILV-----
-------EFLLEKYTKQEPIT-QNALM--KIVSRKYR-----QHFPEVLSTARER-----
----MELVFGLE---------MKE-VDRRG---------NIYT-----------------
-------L----------------------------------IRKLNL-GGN---DCR-R
----DEGALPKSRLL-------MVLLGVIFMNGNR------ATEE---EIWEFLSML---
-----GIY-AGR----RHCIFGEPRRLITKDLVQK------EYLNYRQV-PNSDLPRYEF
----LWGPRACAEIS--KMKVLEVLAKFHGRVPS----S-FPDLYDE---ALRDQAERAG
RR-RAARAPTM-AE----------------------------------------------
----------------------------------------------------------AS
--------------------APS--R-----------------------AKSC-SSSHI-
------------------------------------------------------------
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--------------------------------------MPRGQK---SKLRARGKR-RET
-HD-----QPQGL-----------------------------------------------
-TG-------------PQATAEKQ------------------------------------
-----------------------------------------------------------E
-ESR-----------------------SSSSSSA-----V---------------CQGAR
RRSS----------------------------GSS-------V-------PQESQG---A
S--PTGYPDAGASCSKYDVAA----MGQDEKS------------PSTSRDASVSQESQ-G
ASPIGPPDAGISC---------SKS--------DEAAKGQNEKSPSTSRDASV-----PQ
ESQGASPTG---SPDADVS----GSKSDVAA---------------KGQ---DEESL---
-----------------------------SS-SKRAAFFTTTDGDPIKRKANKMV-----
-------QFLQKKFEKKEPIL-KADML--KRLRRQYK-----PCFPEILKRTSEH-----
----LTVFFGVE---------LKE-TDSSG---------ESYT-----------------
-------L----------------------------------VSKLGL-SNE----GSLS
----GDNALPKSGLL-------MSILGLIFMRGNR------ATEE---EVWKFLGLL---
-----GIY-DGI----LHSIYGDARKIITEDLVQD------KYVVYRQV-CNSDPPCYEF
----LWGPRAYAETT--KMRVLRVLAEINNTSPG----L-YPHLYED---ALTDEVERAL
RLRA--------------------------------------------------------
------------------------------------------------------------
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--------------------------------------MPRGQK---NKLHAREKR-QET
-HG-----QPQDL-----------------------------------------------
-TG-------------PQATAEKQ------------------------------------
-----------------------------------------------------------E
-ESH-----------------------SSSSSSQ-----A---------------CLGTR
RRSS----------------------------DVS-------V-------PQESQG---V
S--PTGSPDAVVSCSKSDVAA----KGQDEKS------------ASTSPEASIPQESQ-G
ASPTGSPDAGVSC---------SKS--------DVAAKGQDEKSPGTSPDAST-----SQ
ESQGASPTG---FPDADVS----GSKYDVAA---------------KGQ---DEESA---
-----------------------------RA-SQKAIIFKRLSQDPLKRKSCALV-----
-------QLLQEKFEKKESIL-KADML--KRIGKRYK-----HYFPEILNRTSER-----
----LAVAFGVE---------LKE-MDSRG---------ESYT-----------------
-------F----------------------------------VSKLGL-SSE----GILS
----DANGLQKSGLL-------MSVLAVIFMKGNR------ATEE---EVWEFLSCL---
-----GIY-AGM----THAIYGDPQKLITEDLVQD------KYVVYRQV-PNSDPPCYEF
----LWGPRAHAETT--KMRVLHVLAKSNNSSPG----L-YPHLYED---ALMDEVERAL
RLRD--------------------------------------------------------
------------------------------------------------------------
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----------------------------------------MSQ-----------------
-----------------KNP-EYAAD-H----------------D-HT----REE-MQN-
-------------LQVAPAS----------------------------------------
-------------------------------------------------------S---D
VEEP----------------------------CSSSHLMAS------------------S
LKGHTS---------------------------------------EET------QVPEDM
EEPCSS-SQLST----AST---QE------------------------------------
---------DP--------------------------------------AYET---PSTS
RGLQHPYV---SSSESA-K--GLGNKEMQ----------------GNS-------VI---
------------P------PD--QP---------------DLPVMTIDGKVNFLV-----
-------NYMLYKYQVKEMMS-MNDIM--TLIVREDE-----HHFHEILMRASER-----
----MEMVFGLE---------VRE-VDPVN---------HFYA-----------------
-------L----------------------------------FIKLGL-TYD----GM--
RA-DE-YSFPKTGLL-------ILILGVVFMKGNR------ATEE---EIWEVLNPM---
-----GIY-AGM----NHFIFGDPRELLTDDFVRE------QYLAYQPI-ANSDPIQYEY
----VWGPRAKAETS--KMKVLEFVAKVHGSDPT----V-FPSQYEE---ALIEEEERTL
AMILEQAGPSS-------------------------------------------------
------------------------------------------------------------
-----------------------A-------SGE----------------SSS--D----
------------------------------------------------------------
---------MGS---------------------NV-------------------------
------------------PHI---------------------------------------
------------------------------------------------------------
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---------SWTRRGCGCR---------------------------AE------------
-------------------------------------------------------NC---
-------------NPDPLS-------------------------------------R---
---------EEGRL----RGGWGWGLRQGSALARG-TRIMSQKMDCGAGLLGFQA-----
--------------------------------------------------------EASV
EDST-LLMQTLM-------EAIQ--IS-EAPPTSQA--TA--------------------
------------------------------------------AASAPNASPQSSQPPAV-
S------------------------------------------------EMAD-------
------TQALATATKPKT------------------------------------------
-----------------------------AF---------------TVQ-----------
-------------NAT----------------TKGPNAAYDFSQAFNAKETP-NMLPTAH
F-------------------KSQNAPP--KGPNAAYD-------FSQAAPT---------
----GELTANKSDMAFKAQNTT-TKVVPNA---------A-YNFSQSLNASEVVNTQPKT
------------------------------------------------------------
----------------------------------------------AFKAWNDTTT----
------------------------------------------------------------
-------------------------------VPS---------ICESDGAAAQTSADGSQ
PQNLE--------------------S---------------------------------R
TIIRGKRTRKINNLNV---------EESSSGDQRRAPLAPGTWRSAPVPVTT-QSPPGAP
PNVLWQTPLA----W-NPS----GWQNQPTRQTP----P-ARQSPPARQTPPAWQNPVAW
QNPVIWPNPVIWQNPVIWPNPI-VWPGPVVWPNPLAWQNPPGWQTPPGWQTPPGWQGPPD
WQG---PPDWPLPPDWT---P-DWPLP-TDWPLPPDWIPTDWPVPPDWQNLRPSPNLRP-
-SPNSRASQNLGASQ-PRDVALL---QERANKLVK------YLMLKD-YTKVPI--KR--
------------------------------------------------------------
----SEM---LRDIIREYTDVYPEIIERACFVLEKKFGIQLKEIDKEEHLYI-LISTPE-
SLAGIL-GTTKDT-PKLG---LLL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPLLGDLRKLLTYEFVKQK-------
---------YLDYRRVPNSNP---P--EYEFLWGLRSYHETSKMKVLRFIAEVQKR---D
------PRDWTAQFMEAADEALDALDAAAA--EAEAR----AEARTRMGIGDEAV-----
------SGP--WSWDDIEFELLT-WDEEGDFGDPWS-RIPF----TFWARYHQNARSRFP
QTFAG---------------------P--IIGPGGTASA------NFAANFGAIGF----
--------FWVE------------------------------------------------
------------------------------------------------------------
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---------------------------------------------------------MSS
----------QLNL------------------------------------------ERAK
DK-----GIQEAV-F---LDEKRTENDPGSALARG-TGAMAQKMDCGAGLLGFQ------
-------------------------------------------------------TEASV
EDST-LLMQTLM-------EAIQ--IS-EAPPTNQA--TA--------------------
------------------------------------------AASGPNASPQSSQPPTA-
N------------------------------------------------EIAD-------
------IQVSAAAARPKT------------------------------------------
-----------------------------AF---------------KVQ-----------
-------------SAT----------------PKGPSGVYDFSQTHNAKEMP-SAQPKAA
F-------------------KSQNGTP--KGPNAAYD-------FSQAAAT---------
----GELAANKSEMAFKAQNAT-TKVGPNA---------T-YNFSQSFNVNEMANNRPKT
------------------------------------------------------------
----------------------------------------------AFKAWNDTTKVPTA
-------------------------------DSQT-----------QNV-----------
----NQA---KMANSQ--------ADIETN--PG---------ITESDGAAAQTSADGPQ
AQNLE--------------------S---------------------------------R
TIIRGKRTRKINNLNV---------EENSSGDQRRAPLSAGTWRSAPVPVTT-QNPPGAP
PNVLWQTPLA----WQNPS----GWQNQTTRQTA----P-ARQSPPARQTPPAWQSPVAW
QNPVIWPNPVIWQNPVIWPNPI-VWPGPVVWPNPLAWQNPPGWQTPPGWQTSPGWQGPPD
WQG---PPDWPLPPDW-PLPT-DWPLP-PDWPLPPDWIPADWPIPPDWQNLRPSPNLRP-
-SPNSRASQNPGASQ-PRDVALL---QERANKLVK------YLMLKD-YTKVPI--KR--
------------------------------------------------------------
----SEM---LRDIIREYTDVYPEIIERACFVLEKKFGIQLKEIDKEEHLYI-LISTPE-
SLAGIL-GTTKDT-PKLG---LLL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPLLGDLRKLLTYEFVKQK-------
---------YLDYRRVPNSNP---P--EYEFLWGLRSYHETSKMKVLRFIAEVQKR---D
------PRDWTAQFMEAADEALDALDAAAA--EAEAR----AEARTRMGIGDEAV-----
------SGP--WSWDDIEFELLT-WDEEGDFGDPWS-RIPF----TFWARYHQNARSRFP
QTFAG---------------------P--IIGPGGTASA------NFAANFGAIGF----
--------FWVE------------------------------------------------
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--------------------------------------MPRGQK---SKLRAREKR-RQA
-RE-----ELEDL-----------------------------------------------
-ID-------------ALAFLEEE------------------------------------
-----------------------------------------------------------E
-ESP-------------------------PSASA-----C---------------LKDVS
QS-S-L------------------------DGASN-------N-------PHGLGE---A
Q--STSTSAT-A------------------------------------------------
------------------------------------------------------------
-----------------AS----HTRHPEGV---------------ND-Q-ME-ERP---
-----------------------------RC-TEDLEATDSFPRGPVDEKVIILV-----
-------HYLLYKYQMKEPIT-KADML--RNVTQMSK-----SQFPVILSRASEH-----
----LELIFGLD---------LKQ-VEPNK---------HIYV-----------------
-------L----------------------------------VNKLDL-GCD----AKLS
----DETGVPKTGLL-------MTVLGIIFTNGNC------VAEE---EVWKVFNTM---
-----GLY-DGI----EHFMFGEPRKLLTKDLVKE------NYLEYQQV-PNSDPPRYQF
----LWGPRAHAETS--KMKVLEFLAKVNNTAPS----E-FSDWYTE---ALQDEEERAR
AR-VAAKARIS-AT----------------------------------------------
----------------------------------------------------------AG
--------------------ARS--K-----------------------VKSS-KSSQLQ
------------------------------------------------------------
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----------------------------------------LS-A----------------
-----------------LRD-LCKME-A----------------ELQA----PAQ-PQT-
-------------LAEALP-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------FGS--EEEA---E---------------------TPS-------
----------T--------------------------------------PSPS-------
S--------------SSVP-----------------------------------------
--------------------PPSSV------------EAEASLWDIRRVMMADLV-----
-------GYLLLKYRAKEPIT-KAEML--GVVPRDAQ-----DQFPDVFCRASAC-----
----MLLAFGLD---------LKE-VDPGE---------HTYA-----------------
-------L----------------------------------VPTLGL-TWD----GVLS
---DDELSLPKTGLL-------VVVLVVIFLQGDC------SLEE---EIWRALGRM---
-----GVC-AGK----VHYIYGEPRALLTQVWVQE------GYLEYRQV-PHSDPARYEF
----LWGPRAHAETS--KVKILEHLLRVNGRVPR----S-CRFLPEE---VVNEEEEGP-
------------------------------------------------------------
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------------------------------------------------------------
------------------MSQ--LSKNLGDSSPPAEAPKPP-------------------
----------VYS----------------------LPWDPPPIDLQA-SLAAWQAPQPAW
EAPQGQLPAPV---VPMTQPPALGGPIVP----------PPT------------------
---------------PGVLMVHP-PPPGAPMAQPPTPGVLMVHPSAPGAPMAHPPP-PGT
PMSHPP-------------------------PPGTPMAH---------------------
-----P---------P------------------PPGTPM----A-------HPAPPGTP
------------------------MAHP--PPPGTPMVHPPPPGTPMVHPPPPGTPMAHP
PPPGTP--MA-------------------QPPPPGTPMAQP---PAPGVLMAQPLTPGVL
MVQPA-------------APGAPMVQPP----PAAVM-------------------TQPP
PSGAPMAKPPGPGVLMIHPPGARAPMTQPPASG---------------APMAQPAAPPAQ
PMAPPAQPMASWAPQAQPVILQIQSQVI----R-------APPQV---P-----------
-------Q---GPQAPPAQLATPPGWQATSPGWQATPQGWQATPLTWQTTQVTWQAPA--
----------IAWQVPPPV-RQGPPPIRP-------------GPPPIRPGPPPVR---QA
PPVIRQ---APPVIRQAPP-VIRQAPPVIRQAPPVIRQAPPVLRQAPPVLRQAPPVIRQA
-PP---------V-----------------------------------------------
--------IRQAPPLIRQAPP-PI------------------------------------
-----------------------------------------------------------R
--------------PAPQVLATQPPLWQALPPPP-----P---------------LRQAP
QARLPAPQVQA------------APQVPTAPPATQ-------VPAAPLAGPQVPQP---V
L--PAPLSAP----------------------------------------LSA-------
----------P-----------QAVH--CPSIIWQAPKGQPPVPHE--------------
------------------------------------------------------------
------------------------------------------------------------
---------IPTSMEFQEVQQ-TQ-AL--AWQAQKAP-----THFWQPLPAQEAQRQ---
----APPMVQLE-------QPFQGAPPCQKAVQIQL-PPQPPQTS--GPQAELPTLQLQP
SWQTPPAVLQAQPGPPLAAANFPLGSAKSLMTP-SGESRASSIDRRGSS-KE----RRTS
SK--ERRAPSKDRM----------IFAATFCAPKA----VSAARAHLPGTWKNLPATPET
FAPSSSVF-PAT----SQFQPASLNAFKGPSAASE----APKSLPYAL---QDPFACAEA
LPAVPWAPQPNMNASKASQAVPTLLM-ATAAAPQ----A-TATT-QE---ASKTSVEMPR
RS-----------------------GKA--------------------------------
--TRK-----KKHLEARE-DSRGHTLA-------------------------------FH
--D-WQGP----RPWENLN--LSDW--EVQSPVQ-V--LGDWEHPNTPRGLSGWEGPSTS
-RI---------------LSG---WEGPSTSWALSAWEGPSTSR-A--------------
---------LGLS---------------ESPRSPLPLVVSEVA-------------G---
VSPGSSATQHNSKVE-AQSLSPL---DERANALVQ------FLLVKD-QAKVPV--QR--
------------------------------------------------------------
----SEM---VKVIIREYKDECLDIINRANNKLECAFGYQLKEIDTQNHAYI-IINKLGY
PTGDLV-ASYLDR-PKFG---LLM----------VVLSL----------IF--------M
-KGNC----V-R--EDLIFNFLFRLGLD--VRETNGLFGNTRKLITEVFVRQK-------
---------YLEHRRIPYTEP---A--EYEFLWGPRAFLETSKMLVLRFLAKLHKK---D
------PRCWPFHYLEALAECEWEDTDEDE-PDS--SDSDSA-------RGP--------
---TSRPPPR--------------------------------------------------
------------------------------------------------------------
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--------------------------------------MPRA-P----------------
-----------------KRR-RYMLE-E----------------GLQS----QSE-TQG-
-------------PVGALLPVAVE------------------------------------
-----------------------------------------------------------E
D-TS-----------------------SS-STCSSSFPSSFPSS----------------
-----------------------------------------------------------S
----SSSCYPLL----SST--PEE--VDD---------------------VAG-------
----------A--------------------------------------PSPP---QSS-
---QSACP---SPTAMA-S--PPLSQSED----------------DSSSS-RGEEGP---
------------S------TSQALP------------YTASFPRNVIDDKVAELV-----
-------EFLLVKYRTKEPTT-KAEML--NTVLRDHQ-----DHFPVIFSEASER-----
----MNLIFGVD---------VKE-VDPSD---------HAYV-----------------
-------L----------------------------------VTTLGL-TYD----GMLS
---DE-QSMPNTGLL-------VMLLGVILLQGDC------APEE---DVWEALSVM---
-----GVR-AGR----EHFIYGEPRELITKVWVQE------QYVEYRQV-PNSDPARYEF
----LWGPRAHAETS--KMSLLEFLASAIGSDPR----S-FPVSYEE---ALRDQEERVQ
ARIASTDNATD-------------------------------------------------
------------------------------------------------------------
-----------------------TA--------S----------------ASC----ST-
------------------------------------------------------------
---------VPS---------------------SSSC-----------------------
------------------PE----------------------------------------
------------------------------------------------------------
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---------------------------------------MSDT-----------------
---------------SE-SGA----------------------------GLTSFQAEASE
KDSS-SMMQTLL-------TVTQ--NVEVPETPKAS------------------KA----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------PEVSEDVKVS-------KTSGVS---------------KAT-----------
-------------EV---------------------------SKTPEAQEAP-ATQASST
-TQLTDTQVLAA----EN--KSLAADT--KKQNADPQ-------AVTMPAT---------
----ETKK-----VSC--------------------------------------------
------------------------------------------------------------
--------------------------------------------------------VA--
-------------------------------DTKV-------------------------
----N-T--KAQETEA--------AASQAPADEP---------EP--ESAAAQSQENQDT
RPKVK--------------------A---------------------------------K
KARKVKHLDGEEDGS---------------SDQSQASGTTGGRRVSKALMASMARRASRG
PIAFWARRAS----RTRLA----A------------------------------------
------------------------------------WARRALL----SLRSPKARRGKAR
RRA---------------------------------------------------------
-AKLQS-SQEPEAPP-PRDVALL---QGRANDLVK------YLLAKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LKDIIKEYTDVYPEIIERAGYSLEKVFGIQLKEIDKNDHLYI-LLSTLEP
TDAGIL-GTTKDS-PKLG---LLM----------VLLSI----------IF--------M
-NGNR----S-S--EAVIWEVLRKLGLR--PGIHHSLFGDVKKLITDEFVKQK-------
---------YLDYARVPNSNP---P--EYEFFWGLRSYYETSKMKVLKFACKVQKK---D
------PKEWAAQYREAMEADLKAAAEAAA--EAKAR----AEIRARMGIGLGSE-----
----NAAGP--CNWD-------------EADIGPWA-KARIQAGAEAKAKAQESG--SAS
TGASTST------NNSA--SA--SAST--SGGFSAGASLTATLTFGLFAGLGGAGASTSG
SSGACG-FSYK-------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
--------------------------------------MPRGQK---SKLRAREKR-HKA
-RE-----ETQGL-----------------------------------------------
-KV-------------AHATAAEK------------------------------------
-----------------------------------------------------------E
-ECP-------------------------SS-SP-----V---------------LGDTP
TSSP-A-------------------------AGI----------------PQKPQG---A
P--PTTTAAAA-------------------------------------------------
------------------------------------------------------------
-----------------VS----CTESDEGA---------------KC-Q-GE-ENA---
-----------------------------SF-SQATTSTESSVKDPIAWEAGILM-----
-------HFMLRKYKMREPIM-KADML--EVVDEKYK-----DRFTEILNGASRR-----
----LELVFGLD---------LKE-DNPSG---------HTYT-----------------
-------L----------------------------------VSKLNL-TND---GNL-S
----NDWDFPRNGLL-------MPLLGVIFLNGNS------ATEE---EIWKFMNML---
-----GAY-DGE----EHLIYGEPRKFITQDLVQE------KYLKYEQV-PNSDPPCYQF
----LWGPRAYAETT--KMKVLEFLAKMNGITPR----D-CPSHYEE---ALRDEEERAR
VR-SSVRARHR-TTAT--------------------------------------------
--------------------------T-------------------------------FR
--------------------ARS--R-----------------------APFS-RSSYPM
------------------------------------------------------------
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--------------------------------------MLLRQ-----------------
-----------------EAQ-SSKAEGR----------------PFQA----QGQ-APG-
-------------LPQL-----RS------------------------------------
-----------------------------------------------------------R
R-P---------------------------------------------------------
------------------------------------------------------------
----ASPPATLI----MGT--VEE------------------------------------
---------VP--------------------------------------DSGS---LSPA
QSPQGASS---SLTITN-D--TPWSQSNE----------------VSSS--NEEEGP---
------------S------TSPDPA------------HLESIFREALDEKVAELV-----
-------HFLLRKYQIKERVT-KAEML--ES-----------NHFPEIFSKASEC-----
----MQVIFGID---------VKE-VDPAG---------HCYV-----------------
-------L----------------------------------VTCLGL-SYD----GLLG
---DD-QSTPKTGLL-------IIVLGMILMEGSC------APEE---AIWEALSVM---
-----GLY-DGR----EHSVYWKLRKLLTQEWVQE------NYLD--------DPVRYEF
----LWGPRALAETS--YVKVLEHVVRVNARVRI----S-YPSLHEE---ALGEEKEGI-
------------------------------------------------------------
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------------------------------------------------------------
---------------------------------------MSDT-----------------
---------------RE-SGA----------------------------GRTRFQAETSE
KDSG-SAIQTLL-------TVTQ--NLEVSETPKAS------------------KA----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------PEVSKDVNVS-------KAPGVS---------------QAT-----------
-------------EI---------------------------SKTPEVQEGA-ATQTSPT
-TQVTDTQ--AA----EN--KSPATDT--KKQNADPQ-------AVTMPAT---------
----ETKK-----VSC--------------------------------------------
------------------------------------------------------------
--------------------------------------------------------VA--
-------------------------------DKKV-------------------------
----N-A--KVPETEA--------AASQAPAVEP---------EP--ESAAAQAQENQDT
RPKVK--------------------A---------------------------------K
KARKVKHLDGEEDGS---------------SDQSQASGTTVGRRVSKALMASMARRASRG
PIAFWARRAS----RTRLA----A------------------------------------
------------------------------------WARRALL----SLRSPKARRGKAR
RRA---------------------------------------------------------
-AKLQS-SQEPEASP-PRDVALL---QGRANDLVK------YLLAKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LKDIIKEYTDVYPEIIERAGYSLEKVFGIQLKEIDKNDHLYI-LLSTLEP
TDAGIL-GTTKDS-PKLG---LLM----------VLLSI----------IF--------M
-NGNR----S-S--EAVIWEVLRKLGLR--PGIHHSLFGDVKKLITDEFVKQK-------
---------YLDYARVPNSNP---P--EYEFFWGLRSYYETSKMKVLKFACKVQKK---D
------PKEWAAQYREAMEADLKAAAEAAA--EAKAR----AEIRARMGIGLGSE-----
----NAAGP--CNWD-------------EADIGPWA-KARIQAGAEAKAKAQESG--SAT
AGASTST------NT--------STST--GSGFSAGASLTATLTFGFFAGLGGAGASTSS
SSGACG-FSYK-------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
--------------------------------------MPRGHK---SKHRAREKR-RET
-HG-----QSQDL-----------------------------------------------
-TG-------------PQTTAEKQ------------------------------------
-----------------------------------------------------------E
-EPR-----------------------SSPSSYP-----V---------------CQGAR
RKTS----------------------------DSS-------V-------PQESQG---A
S--PTASPDAGVSCSKSDVAA----KGQDEKS------------ASTSPNASVPQGSQ-R
XXXXXXXXXXXXX---------XXX--------XXXXXXXXXXXASTSPDASV-----PQ
GSQGASPTA---SLNAGVS----CSKSDVAA---------------KGE---DEESA---
-----------------------------HA-SQRAMYFKSLGRDPISKKSWELV-----
-------QFLQEKFEKNESIL-KADML--KLVSKRYK-----EYFPEILKQTSEH-----
----LVVTFGVE---------LKE-MDSSG---------ESYN-----------------
-------L----------------------------------VSKLGL-SSE----GSLS
----GHNGLAKSGIL-------MSALGLIFMKGNR------ATEE---DVWDFLTFL---
-----GIS-ARM----THPLYGDPEKILTEDLVQA------KYLEYQQV-HNSDPPRYEF
----LWGPRAHFETS--KMKVLNVFAKINNTVPG----F-YPHLYEE---ALIDEVEKAL
RVNF--------------------------------------------------------
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---------------------M-------SLVSQNARR----------------------
------------------------------------------------------------
------------------CNAEIT------------------------------------
-----------------------------------------------------------A
-DY---------------------------------------------------------
-----------------------------------------------------------S
D--GRGEIQA----------------TNASGP------------P-T-------------
---------------------------------------------------PM------L
----------VVDVPQ----CPQAPINPQCV---------------NTSQ-AV-------
---------QDT----N--DLEV--LID-EQSRRLGA---LRVHDPLEDRSIALV-----
-------NFMRMKSQKEGSIQ--QSEM--LEFLREYS-----DQFPEILRRASAH-----
----LDRVFGLN---------LRV-IDPQA---------DTYN-----------------
----------------------L-------------------VSKRGS-QIT----DRIV
----ESLDMPKASLL-------ALVLGHILLNGNR------AREA---SIWDLLLKV---
-----DMW---DKPQRINNLFGNTRNLLTTDFVRM------RFLEYWPV-YGTNPLEFEF
----LWGSRAHS--EITKM-----------------------------------------
------------------------------------------------------------
--------------------------E-------------------------------AL
K-----------------------F---VS----------------DAHDEEP-------
------------------------QSWPE-EYN------------KALEADKTKER---S
---------------------------------------------------------LT-
AG---L--------E-FWSED---TMNDKANDLVQ------LAISVS-EELLPI--HQ--
------------------------------------------------------------
----DEL---LAHTGKEFEDVFPNILNRATLILDMFYGLSLIEVDTSEHIYL-LVQQPES
EEEQVM-LESLGR-PTQE---YVM----------PILGL----------IF--------L
-MGNR----V-K--EANVWNLLRRFSVD--VGRKHAI--------TCKLMRQR-------
---------YLECRPLSYSNP---V--EYELLWGPRAHHETTKMKVLEYMARLYRK---R
------PQDWPEQYREAVE-----------DEEARAKSEATTMFF----LGP--------
---M--------------------------------------------------------
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--------------------------------------------------RWQKSE---S
R--------------------------------------------------GFPTP----
-------QAG----------------------------GEKDGSHDGETQALA-----S-
-Q----------E----------GPEEDLGA---------------GREE-G--------
----------------PARE-------------------GARVWRRQSRTVGEPV-----
-------QLLLVKDKRKSPST-RSEIA--KHVLGG-K-----DLFPA------EH-----
----LR-CVGFE---------LKQ-LDRKH---------HI-------------------
-------L----------------------------------INRLQPPE----------
-EEDLGGDGPKLGLL-------VMILGFIYMKGNS------AREV---QVWEMQRRL---
-----GMR-PSK----YRFLFGYPKRLIMEDFVQE------PDLGYRRV-PLTNPLEYAF
----SWGPSSL--IS--KIKVWGFGAKLHKEVPN----Q-WPVQYRE---ALADKTDRAR
AEVS-IRRASAGI-----------------------------------------------
------------------------------------------------------------
--R----H----------------------------------------------------
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------------------------------------------------FRQASAC-----
----MQLVFGVD---------VQE-LEPDS---------NIFT-----------------
-------L----------------------------------VNTLGL-TLD--------
---ST-DSLPKMGIL-------VLVLSVIYMEGER------ASEE---EVWDALRVM---
-----GVY-SGQ----KHDIYGEPRELLTRVWVQE------RYLQYEQA-AGSWPPRYDF
----LWGSRAHTETN--KLKILQFLANINESDPR----A-FPLWYEK---ALKERQDQSQ
DKVDELPS----------------------------------------------------
------------------------------------------------------------
------------------------T------VGA----------------SP---G----
------------------------------------------------------------
---------VPS-----------------------RSL----------------------
---------------------S------PK------------------------------
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------------------------------MPR---------------------------
----------------------GNKSK---------------------------------
-SR-----------------SRAKRQ-QMRGEKPK---LQGAQPTGKEEGK------AA-
-SP-------------------ALD-QGD-GPSSSDRGTAQESQ-E-------------A
---------ASHI---S-------------PELNVSHPVHDVG---------AEG SFAGV
DERRANVSIIADAIQ-CARRDPL---TRKASKVLH------YLLEKY-QKDEQP--VE--
------------------------------------------------------------
----GEM---L KLIGRKYKVHFPQILEKATYQLELVYGLELKVDNPATHSYV-LVSKLPI
LPGADV-GGRREL-PKTG---LIL----------TILGM----------IF--------M
-KGNR----A-T--EEEVWQFLHMQGIY--PGRRHLIFGEPRNFITKVLVEQN-------
---------YVEYRQVPGSDP---P--THEFLWGPRAHEESTYRKVMDILAKIKSA---I
------PSYYPQQYEETLSNQAERAARRDE-AGGFHAA---RIPS----HAQASSSSHI-
------------------------------------------------------------
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------------------------------------------------------------
------------------MSQ--LSKNLGDSSPPAEAPKPP-------------------
----------VYSRPTVLMRAP-----PASSRAPPVPWDPPPIDLQA-SLAAWQAPQPAW
EAPQGQLPAPV---VPMTQPPALGGPIVPAPPLGGPMGKPPT------------------
---------------PGVLMVHP-PPPGAPMAQPPTPGVLMVHPSAPGAPMAHPPP-PGT
PMSHPP-------------------------PPGTQLGP---------------------
-----T---------P------------------PSLRGPRTGPT-------PPSLRDPG
------------------------LVHP--PPPGTPMAHPPPPGTPMAHPPPPGTPMAHP
PPPGTP--MA-------------------HPPPPGTPMAQP---PAPGVLMAQPLTPGVL
MVQPA-------------APGAPMVQPP----PAAVM-------------------TQPQ
PSGAPMAKPPGPGVLMIHPPGARAPMTQPPASG---------------APMAQPAAPPAQ
PMAPPAQPMASWAPQAQPLILQIQSQVI----R-------APPQV---P-----------
-------Q---GPQAPPAQLATS-------PGWQAAQQGWQATPLTWQTTQVTWQAPA--
----------VTWQVPPPM-RQGPPPIRP-------------GPPPIRPGPPPVR---QA
PPLIRQ---APPVIRQAPP-VIRQAPPVIRQAPP-------VIRQAP-------------
------------------------------------------------------------
-----------------PAPP-PI------------------------------------
-----------------------------------------------------------R
--------------PAPQVLATQPPLWQALPPPP-----P---------------LRQAP
QARLPAPQVQA------------APQVPTALPATQ-------VPAAPPAGPQVPQP---V
L--PAPLSAP----------------------------------------LSA-------
----------P-----------QAVH--CPSIIWQAPKGQPPVPHE--------------
------------------------------------------------------------
------------------------------------------------------------
---------IPTSMEFQEVQQ-TQ-AL--AWQAQKAP-----THIWQPLPAQEAQRQ---
----APPLVQLE-------QPFQGAPPSQKAVQIQL-HPQQAQAS--GPQAEVPTLPLQP
SWQAPPAVLQAQPGPPVAAANFPLGSAKSLMTP-SGECRASSIDRRGSS-KE----RRTS
SK--ERRAPSKDRM----------IFAATFCAPKA----VSAARAHLPAAWKNLPATPET
FAPSSSVF-PAT----SQFQPASLNAFKGPSAASE----TPKSLPYAL---QDPFACVEA
LPAVPWVPQPNMNASKASQAVPTFLM-ATAAAPQ----A-TATT-QE---ASKTSVEPPR
RS-----------------------GKA--------------------------------
--TRK-----KKHLEAQE-DSRGHTRA-------------------------------FH
--D-WQGP----RPWENLN--LSDW--EVQSPIQ-V--SGDWEHPNTPRGLSGWEGPSTS
-RI---------------LSG---WEGPSASWALSAWEGPSTSR-A--------------
---------LGLS---------------ESPGSSLPVVVSEVA-------------S---
VPPGSSATQDNSKVE-AQPLSPL---DERANALVQ------FLLVKD-QAKVPV--QR--
------------------------------------------------------------
----SEM---VKVIIREYKDECLDIINRANNKLECAFGYQLKEIDTKNHAYI-IINKLGY
HTGNLV-ASYLDR-PKFG---LLM----------VVLSL----------IF--------M
-KGNC----V-R--EDLIFNFLFKLGLD--VRETNGLFGNTKKLITEVFVRQK-------
---------YLEYRRIPYTEP---A--EYEFLWGPRAFLETSKMLVLRFLAKLHKK---D
------PQSWPFHYLEALAECEWEDTDEDE-PDT--GD--SA-------HGP--------
---TSRPPPR--------------------------------------------------
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--------------------------------------MPRGQK---NKLHAREKH-QET
-HG-----QPQDL-----------------------------------------------
-TG-------------PQATAEKQ------------------------------------
-----------------------------------------------------------E
-ESH-----------------------SSSSSSQ-----A---------------CLGTR
RRSS----------------------------DVS-------V-------PQESQG---V
S--PTGSPDAVVSCSKSDVAA----KGQDEKS------------ASTSPEASIPQESQ-G
VSPTGSPDAGISC---------SKS--------DVAAKGQDEKSASTSLEASI-----PQ
ESQGASPTG---SPDAGVS----GSKYDVAA---------------EGQ---DEESA---
-----------------------------RA-SQKAIIFKRLSQDPLKRKSCALV-----
-------QLLQEKFEKKESIL-KADML--KRIGKRYK-----HYFPEILNRTSER-----
----LAVAFGVE---------LKE-MDSRG---------ESYT-----------------
-------F----------------------------------VSKLGL-SSE----GILS
----GANGLQKSGLL-------MSVLAVIFMKGNR------ATEE---EVWEFLSCL---
-----GIY-AGM----THAIYGDPQKLITEDLVQD------KYVVYRQV-PNSDPPCYEF
----LWGPRAHAETT--KMRVLRVLAKSNNSSPG----L-YPHLYED---ALMDEVERAL
RLRD--------------------------------------------------------
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------------------------------------------------------------
------------------MSL--VSQNSRRRRRRCAR---AT------------------
--------------------APNAPDLSAAVTGPDGPQGPNEPQILQ-GFNAS-------
---EG-----------------PGI------------SVPPT------------------
---------------SGEGPST---------FVLLPAA---ESSSASGQFSI-SEG-PNT
SKLPTP---------------S-EC----PGISGPPTVS---------------------
-----DALSGAMSITASQGPS------SSVPRTASEGSRA---PQ-------HPTVCEGL
-----------------------------------SPSVPSAS--------GEGPSTSVS
PTGSKALGIS----------------VFSVPPTLGEGLNTS-------EP--PTDADSPG
INV-------------------------------------------------------PP
S------SQEGPSSSMPVTPGEGLSISVLSTDS---------------EGPGIH------
------------------------------------------------------------
------------------------------------------MPPLSGEDPSSAVLPTAC
EGSSASV---------QPPIGEGGSSSMP---------------PTGGEGLST-------
------------------------------------CALPSGCE-----SRGICGLIPSV
----------ASP----------------------------------------------S
GEGPSAF---------LLPGD---------------------------------------
------------------------------------------------------------
-----------------------------CEALESCALPP---------------CGEGR
HNYASH---IP------EEVP-CTSRMPTAAEDPS-------I-SGM---PT--------
---------------------------ACEN-----------------------------
------PDALLSLSA------MGPNSSKAS------------------------------
------------------------PRMNRIS---------------N-------------
-------GAEGPLGFQVLRDRENSNCITIMGLGTGQVVLTLKPQDPMEHNVAELL-----
-------QFLLVKDQSKYPIR-ESEMR--DFIVKEYR-----SQFPEILRRAAAH-----
----LECIFRFE---------LKE-LDPED---------RTYI-----------------
-------L----------------------------------LNKLGPVPFD-----GLE
----DRPNGPKMGLL-------MLILGQILLNGNQ------AREA---EIWEMLWRL---
-----GVQ-RER----RLSIFGNPKRLLSVEFVWQ------RYLDYRPI-TDCSPVEYEF
----FWGPRSHVETT--KMKILKFMAKIYNKDPR----D-WPEQYHE---AVEEEAIRAA
AGD---------------------------------------------------------
------------------------------------------------------------
----WPAVHHYRRPYFEE----------AAAE------------------IAI-HD----
-AD---------------------------------------------------------
---------ISGY-------------------------S---------------------
---------SKYAPH-SWPESRL---ESKSRKLVQ------LFLLMD-ATKLPI--PK--
------------------------------------------------------------
----KGI---LYYIGRECSKVFPDLLNRAARTLNHVYGTELVVLDPRNHSYT-LYNRREM
EDTEEI-MDSPNR-PGNN---FLM----------QVLSF----------IF--------I
-MGNH----A-R--ESAVWAFLRGLGVQ--SGRKHAI--------TCRYLSQR-------
---------YIDSLRVPDSDP---V--QYDFVWGPRARLETSKMKALRYVARIHRK---D
------PQEWPEQYREALEDEANRADAGHR-QF----------LVHNFR-----------
------------------------------------------------------------
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------------------------------MPR---------------------------
----------------------AHKRK-------------------------------GR
--------------------APKKSR-HTGQDPQA---HR-AAQGGTELAEEP-SSSSP-
---------------------VLEDIPRS-SSAAVSGTPPPRPS-S-------------P
---------P-ST---S------------TTSGRVPDTRPHEG------D-----DSQGE
EEQ QPPSSGVTPSAD-RSHSDAL---ATKVDLLEQ------FLLYKY-KMKQPI--MK--
------------------------------------------------------------
----ADM---LMVVNTKCPHLFAEILQGASRSIEALFAVEVKEINSTCQSYD-LVSKLKL
PNNGRV-RPGRGL-PKTG---LLM----------TLLGV----------IF--------M
-KGNR----A-T--EEDVWKFLNTMRIY--AGRKHFIYGEPRKLITKDLVRLQ-------
---------YLEYRRLPDTDP---A--RYEFLWGPKAHAETSKMKVLEFVAKARDT---V
------PTAFPSQYEEALRDQEERARVGTA-ATPGATARA------RLRSCTCPAASSLL
LKSKDICYPE-ENLSHHDRSCL--------------------------------------
------------------------------------------------------------
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---------------------------------------MSDT-----------------
---------------SE-TGT----------------------------GPTRSQAETSE
KESD-LKAQTVL-------TVTQ--NLEVSETPKAS------------------KA----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------PEVSEAEKVS-------KAAGVS---------------KAT-----------
-------------EV---------------------------SKAPEAPEAA-DTKESST
-TKQTDTQSLAA----EK--KSPAAAT--EVQKADPP-------ERSAEWL---------
----IL--------RS--------------------------------------------
------------------------------------------------------------
--------------------------------------------------------IQ--
-------------------------------RPR--------------------------
-----------RLRLM--------PLRLRKADEP---------EP--EGTVAQAQENQDT
RPKVK--------------------A---------------------------------K
KARKVKHLNGEEEGS---------------SDQSQASGTTGGRRVSKALMASMARRASRG
PIAFWARRAS----RTRLA----A------------------------------------
------------------------------------WARRALL----SLRSPKARRGKAR
RRA---------------------------------------------------------
-AKLQA-SEEPEAPP-SRDVALL---QGRANELVK------YLLAKD-QTKIPI--KR--
------------------------------------------------------------
----ADM---LKDIIKEYTDVYPEIIERAGYSLEKVFGIQLKEIDKNDHLYI-LLSTLEP
TDAGIL-GTTKDS-PKLG---LLM----------VLLSI----------IF--------M
-NGNR----S-S--EAVIWEVLRKLGLR--PGIHHSLFGDVKKLITDEFVKQK-------
---------YLDYARVPNSNP---P--EYEFFWGLRSYHETSKMKVLKFACKVQKK---D
------PKEWAAQYREAMEADIKAAAEAAA--EAKAR----AEIRARMGIGLGSE-----
----NAAGP--CNWD-------------EADIGPWA-KARIQAGAEAKAKAQ--ESGGAS
TGASAGASAGASA------SAGASASA--SGSFGASASLPTTLTFGLFSGLSGTGANSSG
SSGACG-FSYK-------------------------------------------------
------------------------------------------------------------
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--------------------------------------------DPLTKEVDTLV-----
-------QLVLQTYKLKKLVI-KEDML--KIVNKKYK-----SRFHEILRRASFS-----
----TEVVFGID---------LKE-IDSVK---------PSYA-----------------
-------L----------------------------------VSKMDL-PND----GRLS
----RGRGLPKTGVL-------MILLGVIFMKGNC------ASEE---KIWEFLNKM---
-----RI-----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------FAGKRH-FIFGEPRK---LITQDFVKLKYLEYR-QVPNS-
-DP-------------------PSY-EF-------LWGPRAHAE-TSK---MK TLEFLAK
---------INDT---V-------------PSALPSLCE----------------EALRV
NKEKVRK--YSAIMA-FWGGDPL---TRRVTM LLQ------FLLSKY-EMREHI--TK--
------------------------------------------------------------
----GKM---LKIINKRYKEHFPEILRRASKCIELVFGLDVKEVDSKGQSYT-IVSKLEI
TEEEKL-SGGRGI-PKTG---ILM----------PLLSM----------IY--------K
-NGNR----A-T--EEKMWEFLNVFGMY--DG-------EPRKLITKDLVQAK-------
---------YLEYRQVPNSDP---P--RYEFLWGPEAQAEASKTKVLEFLAKVKDT---N
------SSALQALYKETWGDEEETASGREW-AGAC-------------------------
------------------------------------------------------------
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--------------------------------------MPRGQK---SKLRAREKR-RET
-HG-----QPQGL-----------------------------------------------
-TG-------------PQVTAEKQ------------------------------------
-----------------------------------------------------------E
-ESR-----------------------SSSSSSA-----V---------------CRSAR
RRSS----------------------------DSS-------V-------PQESQG---A
S--PTGSPDAGVSCSKSDVAA----KGQDEKS------------PSTSRDASVSQESQ-G
ASPTGSPDAGVSC---------SKS--------DMAAKGQDEKSPSTSPDASV-----PQ
ETQGASPTG---SPDADVS----GSKSDVAA---------------KGQ---EGESI---
-----------------------------SP-SERIVFFTTADRDPLNRKASKMV-----
-------QFLQKKFEKKESIL-KADML--RRVRREYK-----PCFPEILKRTSER-----
----LAVAFGVE---------LKE-MDSSG---------ESYT-----------------
-------L----------------------------------VSKLGL-SSE----GSLS
----GDNALPKSGLL-------MSLLGLIFMKGNR------ATEE---EVWEFLGVL---
-----GIY-DGI----LHSIYGDTRKIITEDLVQD------KYVVYRQV-RNSDPPRYEF
----LWGPRAHAETT--KMKVLRVLAEINNTSPG----L-YPHLYED---ALIDEVERAL
RLRA--------------------------------------------------------
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-----------------------S------------------------------------
-----------------------------------------------------------S
------------------------------------------------------------
------------------------------------------------------------
-------YSVLF----LGT--GEEA---A---------------------DSG-------
----------T--------------------------------------PSPT-------
QSPQGVCP---SPTA-VAA--PPWSQSED----------------NGLRS-QGEEGP---
------------S------SGQDPA------------DAESRLQDALHLMMAELM-----
-------GFLLHKYRTKQPTS-KEEML--NAVLRDDQ-----DHFPVVLSQASEC-----
----LQLVFGVD---------VKE-VDPRE---------HLYV-----------------
-------L----------------------------------VPTLGL-TYD----GMQD
---DG-QSMPNTGLL-------VILLGVIVLEGDF------APEE---AVWRALSKM---
-----GLC-AGR----EHFIYGEPRELITNVWVQE------GYVEYRQV-ANSDPARYEF
----LWGPRAYTETS--KLQVLEHFLRVNRKGPS----S-FPSLSEE---RVSDEEEGA-
------------------------------------------------------------
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--------------------------------------------------------MAE-
----------------------------------------------------------GS
FS-----V-Q-------SESYSVEDMDEGSDEVR--EEEMVEGNDYE----EFGAFGGYG
TLTSFDIHI--LRAFGSLG-----------------------------PGLRILSNEPWE
LENP-VLAQTLV-------EALQ--LDPDTLANETAARAA-------------NVARAAA
---S----------NRA-ARAA--------------------AAAARTAFTQV---VASH
R-------------------------------------------------VAT-------
------PQVSGEDTQPTTYAA--EAQ--------------------GPTPEPPLASPQTS
------QMLVTSEMAAPGAPVT-STKSQTGS---------------PAQ-----------
-------------EAA----------------TEGPSSACAFSQAPCAREVD-TTRPSTA
FLGQ----------------------------NDVFD-------FTQPAGV---------
----SGMAFPRPKRPAPAQEA--ATEGSSA---------AS-GVPQTGPGREVAATRPKT
T-----------------------------K-----------------------------
------------------------------------------------------------
--------------------------------------------------------SGKA
LAKTRWVEPQNVVAAA--------AAKA-KMATS---------IPEPEGAAA--ATAQHS
AE-----------------------P---------------------------------W
ARMGGKRTKKSKHLDDEY--------ESSE-EEREPPAVPPTWRASQPSLT---------
---------V----R---------------------------------------------
----------------------------------------AQLA----------------
-----------------PRRP-----------------------------V----A----
-PRSQIPSRHVLCLP-PRNVTLL---QERANKLVK------YLMIKD-YKKIPI--KR--
------------------------------------------------------------
----ADM---LKDVIREYDEHFPEIIERATYTLEKKFGIHLKEIDKEEHLYI-LVCTRDS
SAR-LL-GKTKDT-PRLS---LLL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPFLGDLRKLITDDFVKQK-------
---------YLEYKKIPNSNP---P--EYEFLWGLRARHETSKMRVLRFIAQNQNR---D
------PREWKAHFLEAVDDAFKTMDVDMA--EEHAR----AQMRAQMNIGDEAL-----
------IGR--WSWDDIQVELLT-WDEDGDFGDAWA-RIPF----AFWARYHQYILNSNR
ANRRA------TWRAGVSSGTNGGASTSVLDGPSTS-ST---IRTRNAARAG--------
----ASFFSWIQHR----------------------------------------------
------------------------------------------------------------
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----------------------------------------RGKKE--VNPRAREKP-DRP
-KL-----EAGRV-----------------------------------------------
-LM-------------P-TSSEEG------------------------------------
-----------------------------------------------------------D
-ESS-------------------------SSSFS-----S----------------EVSS
LGTP-E-------------------------PAL----------------SQEPQG---A
T--AA-------------------------------------------------------
------------------------------------------------------------
-----------------IS----SPRKAGAS---------------GG-G-AS----G--
---------------------GGASGA--GA-SGAGSWSDEPRRSPLDQKAMLLA-----
-------QFMLRKYNMKQPIT-REDMM--KHVVRKHK-----SYFQEILKRATEL-----
----MVLVFGID---------VKE-ADPAG---------QSYV-----------------
-------L----------------------------------VSKLHH-RGD----SSLH
-----GKIMPKKGLL-------MTILCVIFMKGNC------ATEE---EIWDVLNAM---
-----GIH-AGK----EHNLHGEPTKLITEDLVKE------GYLEYRLV-PHSDPPSHEF
----LWGPQAYAETS--KMEVLEFLAKLHDTQPS----A-FPHWYEE---ARQDELERTR
QR----------------------------------------------------------
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--------------------------------------MSLEQ-----------------
-----------------RSL-HYKPE-E----------------ALEA----QEE-ALG-
-------------LVCVQA-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---AASSSSPLV----LGT--LEE------------------------------------
---------VP--------------------------------------TAGS---TDPP
QTPQGASA---FPTTIN-F--SRQRQTNE----------------SSSS--YEEERL---
------------S------TSRIL---------------EFLFRAVLTKKVDNLV-----
-------HFLLLKYRAREPVT-KAEML--ESVIKNYK-----HCFPVIFGKASES-----
----LKMIFGID---------VKE-ADPTG---------HSYV-----------------
-------L----------------------------------VTCLGL-SYD----GLLG
---DN-QIMPKTGFL-------IIILVMIAMEGGH------APEE---AIWEELNVM---
-----EVY-DGR----EHSAYGEPKKLLTQDLVQE------KYLEYRQV-PYSDPARYEF
----LWGPRALAETS--YVKVLEYVIKVSARVRF----F-FPSLREA---ALREDKEGF-
------------------------------------------------------------
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------------------MS----------------------------------------
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--V---------------------------------------------------------
------------------------------------------------------------
-----------------------------------------PCREGG----LK-----S-
-AGKMSQKKKMKR----------RPGTQSEL---------------HQSQ-GEDMD----
----------------VEEDQCPTQTQ--TA-SQMRPNLEKPSMAQVDQKVNELV-----
-------QYLLVKDQKKLPIK-RADIL--RNVIKEYK-----GVSSEIVKGAGQV-----
----LEKVFGLH---------LKE-IDQKN---------HVYI-----------------
-------I----------------------------------VNMLERLEGD-----NMR
----VDDNTAKMGLL-------MVILSLIFMKGSA------TNES---VIWETLRKL---
-----RVD-TRE----RHEVFGDVKKLVTEEFVRQ------KYLEYNRI-PHTEPVEFEF
----QWGARATKETT--KMQVLNFVAKIQKKDPK----S-WTVQYSQ---ATEGASASGA
------PLR-H-------------------------------------------------
------------------------------------------------------------
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------------------------------MPR---------------------------
----------------------GQKSR-------------------------------HH
--------------------GRAKRR-HDQNKAQS---CRDGQQTATAAEAPP-P-----
-------------------------SLQS-LPVAESCSTPQEPQ-G-------------A
---------AHAT---A-------------ASAADSYTASGNN-------------PTGQ
DKERKS TYNTLIPTH-S-LDREL---CGMIVLLEQ------FLLYKY-KMKQPI--FR--
------------------------------------------------------------
----ADM---LKLIKRSHLHKFDEILKKASEHIDIVFALEMKEGDSAFRSYD-LVSKLKL
PNNGRV-RPGRGL-PKTG---LVM----------NILGM----------IF--------M
-KGNR----A-T--EEDVWKLLSMMGVY--AGRKHFIYGEPRKLITRDLVRLQ-------
---------YLEYQQVPDTDP---A--RYEFLWGPKAHAETSKMKVLEFVAKINDT---V
------PAAFPSQYEDALRDEEERARTKHA-AMPSNVARASGALKFR--CSVCSSTHS--
------------------------------------------------------------
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--------------------------------------MPHS-P----------------
-----------------KRL-RLAFE-P----------------DFQT----QIE-IQG-
-------------LKVADVLIAED------------------------------------
-----------------------------------------------------------K
E-ET-----------------------SSVSSCSFNF--SYPST----------------
-----------------------------------------------------------S
---SSPPSSPVI----PLS--PEKEEEE--------------------------------
-----E-PAAT--------------------------------------LSPP-------
QSPQSSFC---SFSASWNT-------SEE----------------V-SNS-QEVEDT---
------------G------SLETST------------DNESLPRDPLDEGVADLV-----
-------HFMILKYRLKEPIT-KAEML--KVVVEKYK-----EKFPVIFKKASKC-----
----LEVISGID---------VKE-VDPTT---------HSYV-----------------
-------L----------------------------------VNSLDL-THD----EMLS
---DN-QSMPKNGLL-------IIILGVIFIEGNC------APEE---DIWDFLNMI---
-----GIY-AGR----EHFIYGEPRKLITTDWVQE------NYLEYRQV-LNSHPPRYEF
----LWGPRAHAETS--KMKVLEFLAKIKGTDPI----S-FSCWYEE---ALRDEEGRAQ
ARTESVDNTAT-------------------------------------------------
------------------------------------------------------------
-----------------------TF--------I----------------AQHW---SA-
------------------------------------------------------------
---------ASS---------------------APTE-----------------------
--------------------E---------------------------------------
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----------------------------------------MDT-----------------
---------------SQ-SGT----------------------------GPTRVQTEASE
KDSS-LKTQTLL-------TVTQ--NLEVSETPKAS------------------KA----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------PVVSKAVKVS-------NAAGVS---------------KAT-----------
-------------EV---------------------------SKATEAQEVT-ATQSSPT
--TLTDTQVLAA----ER--KSLAADT--KMQNADPQ-------AVTMPAT---------
----ETKK-----VSC--------------------------------------------
------------------------------------------------------------
--------------------------------------------------------VA--
-------------------------------DTKV-------------------------
----N-T--KVLETEA--------SASQAPGDEE--------------PEGAQAQENQDT
RPKVK--------------------A---------------------------------K
ARKXXXXXXXXXXXXXXXXXXXXXXXXX------------XXXXXXXXXXXXXXXXXXXX
XXXXXXXXXX----XXXXX----X------------------------------------
------------------------------------XXXX-XX----XXXXXXXXXXXXX
XXX---------------------------------------------------------
-XXXXX-X---XXXX-XXXXXXX---XXXXXXXXX------XXXXXX-XXXXXX--XX--
------------------------------------------------------------
----XXX---XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXX
XXXXXX-XXTKDS-PKLG---LLM----------VLLNI----------IF--------M
-NGNR----S-S--EAVIWEVLRKLGLR--PGIHHSLFGDVKKLITDEFVKQX-------
---------XXXXXXXXXXXX---X--XXXXXXXXXXXXXXXXXXXXXXACKVQKK---D
------PKEWAAQYREAMEADMKAAAEAAA--EAKAR----AEIRARMGIGLGSE-----
----NAAGP--CNWD-------------EADIGPWA-KARIQAGAEAKAKAQESG--GAS
AG----------------------ASA--GSSFSASTSLTATLTFGLFSGLGGAGASTSG
GSGACG-FSYK-------------------------------------------------
------------------------------------------------------------
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--------------------------------------MDDAH-----------------
-----------------NIQ-YCNLQ-D----------------NAQA----EQK-----
-------------LDNAQAT----------------------------------------
------------------------------------------------------------
--------------------------------------MAAA------------------
------------------------------------------------------------
---EEEE-ATTT----SKA--E--------------------------------------
----------Y--------------------------------------GSGI---PSPL
QSPERACS---PSVALA-S--IPEG------------------------P-SEEASI---
------------R------QLQALE------------DPLFLLHNAQNVKVYDLV-----
-------DFLLFKYQTKAFTT-KAEML--ETIGREYD-----EYYPLIFSEASEC-----
----MKLVFGLD---------IVE-VDPSV---------HSYV-----------------
-------L----------------------------------VTALGI-TYD----GM--
LT-DV-QGMPKTGVL-------IVVLGVIFMKGNY------VSED---IIWEMLNNI---
-----GLC-GGM----DPYIHRDPRKLISEEFVQE------GYLEYRQV-PNSDPPSHVF
----LWGPRAFAETT--KLKILQFFASITKTHPR----A-YPEKYAE---ALRDEIDRVE
AWIFQQM-----------------------------------------------------
------------------------------------------------------------
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--------------------------M--VDVIGSYK-----KWCRSILRRSSLI-----
----LARVFGLH---------LRL-TSLHT---------MEFS-----------------
-------L----------------------------------VRALGPEELD-----RMA
----LSNRMPMTGLL-------LMILSLIYVKGRG------ARES---AVWNVLRIL---
-----GLR-PWK----KHSTFAEVRRLITEDFVQQ------NYLKYQRV-PHVEPPEFEF
----FWGSRASREIT--KMQIMEFLARVFKKDPQ----A-WPSRYRE---ALEEARALRE
ADLAA----------------------------------HYPHASVSQD-----------
------------------------------------------------------------
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--------------------------------------------------MLQTPE---S
R--------------------------------------------------GLPVP----
-------QAE----------------------------GEKDGGHDGETRAPT-----A-
-SQE-------------------RPKEELGA---------------GREE-G--------
----------------AAEPALTRKGA--RA-LAAKALARRRAYRRLNRTVAELV-----
-------QFLLVKDKKKSPIT-RSEMV--KYVIGDLK-----ILFPDIIARAAEH-----
----LRYVFGFE---------LKQ-FDRKH---------HTYI-----------------
-------L----------------------------------INKLKPLEEE--------
EEEDLGGDGPRLGLL-------MMILGLIYMRGNS------AREA---QVWEMLRRL---
-----GVQ-PSK----YHFLFGYPKRLIMEDFVQQ------RYLSYRRV-PHTNPPEYEF
----SWGPRSNLEIS--KMEVLGFVAKLHKKEPQ----H-WPVQYRE---ALADEADRAR
AKAR-AEASMRARA--------SARA------G---------------------------
------------------------------------------------------------
-IH----L------W---------------------------------------------
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--------------------------------------------------MLQTPE---S
R--------------------------------------------------GLPVP----
-------QAE----------------------------GEKDGGHDGETWART-----A-
-SQE-------------------RPKEELGA---------------GREE-G--------
----------------AAEPALTRKGA--RA-LAAKALARRRACRRLNRTVAELV-----
-------QFLLVKDKKKSPIT-RSEMV--KYVIGDLK-----ALFPDIIARAAEH-----
----LRYVFGFE---------LKQ-FDRKH---------HTYI-----------------
-------L----------------------------------INKLKPLEEE----E---
EEEDLGGDGPRLGLL-------MMILGLIYMRGNR------AREA---QVWEMLHRL---
-----GMQ-PSK----YHFLFGYPKRLIMEDFVQQ------RYLSYRQV-PHTSPPEYEF
----SWGPRSNLEIS--KMKVLGFVAKLHKKEPQ----H-WPVQYRE---ALADEADRAR
AKAR-AEASMRARA--------SARA------G---------------------------
------------------------------------------------------------
-IH----L------W---------------------------------------------
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------------------------------SEDAFEPT---KGAPSSPQI----------
---------KWSLDLPR------------------------DRSPR-RPERITGGEDLLS
MVHISAESALTLPLSPGLWFPITQILPTVLPADLTRVTMPLGQ-----------------
-----------------RSH-HCKPE-E----------------GLQA----QEE-APG-
-------------LVG-AQALSVE------------------------------------
-----------------------------------------------------------Q
Q-E---------------------------------------------------------
------------------------------------------------------------
---TASLSCTVN----AGT--LEE------------------------------------
---------VP--------------------------------------AAES---PSPS
QSPQGASS---SPTAMD-S--ISWVLSDE----------------GCCS--QEEEGP---
------------S------TSPDLA------------DPESFLQDTLHEKIIDLV-----
-------HLLLHKYRVKKLIT-KAEML--ESVIKNYE-----EYFPEIFREASEC-----
----TKLLFGID---------VKE-VDPIS---------HSYV-----------------
-------L----------------------------------ITSLGL-SYD----GILG
---DK-HSMPKSGLL-------IIVLGIIFMEGNC------ASEK---VMWEVLSIM---
-----GVY-AGR----EHFLFGEPKKLLTQDWVEE------KYLVYRQV-PGSNPTCYEF
----LWGPRAHVETS--KMKVLEYIANANGRDPT----S-YPSLYEE---ALRVEGEGV-
------------------------------------------------------------
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--------------------------------------LPLEQ-----------------
-----------------RSQ-HCKPE-E----------------GLEA----RGE-ALG-
-------------LVGAQVPVTEE------------------------------------
-----------------------------------------------------------Q
E-S---------------------------------------------------------
------------------------------------------------------------
----ASSSSTLV----EVT--LGE------------------------------------
---------VS--------------------------------------AAD------PQ
----GAST---LPTIIN-C--TLWSQSDE----------------GSSN--QEEEGP---
------------S------TFPDL---------------ETGFQAALSRKVAELV-----
-------HFLLLKYRAREQFT-MAEIL--E-----------SYFFPVIFSKASEY-----
----LQLVFGIE---------VME-VVPIG---------HLYI-----------------
-------L----------------------------------VTCLGL-SDN----GLLG
---EN-QIMPTTDLL-------IIILATVAIEGDG------APEE---KVWEELSVL---
-----ELS-GRR----EDSVLANPRKLLTQVLVQE------NYLEYRQV-PFSDHACYEF
----LWGPRALVETS--YVKVLYHMLKITGEPRI----S-YPPLHEW---AWREGEE---
------------------------------------------------------------
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------------------------------------------------------------
--------------------------------------MPRGQK---SKLRAREKR-CQA
-RG-----EPQSL-----------------------------------------------
-EG-------------PQATAANV------------------------------------
-----------------------------------------------------------E
-E---------------------------SSDSP-----V---------------SGDTL
PSPP-A-------------------------ADT----------------SQEPRG---S
P--AT-SSPTAG------------------------------------------------
------------------------------------------------------------
-----------------VS----CPRSNVDA---------------KS-Q-AE-KMK---
-----------------------------NS-SQASTSPESAHKDLLTRKVGVLM-----
-------QFLLEKYTMGAPIL-KSDML--KIIHRRYK-----EHFPEILRKASEH-----
----MELVFGLE---------LKE-VKPGG---------HSYI-----------------
-------L----------------------------------VSSLDL-TAD---GSV-S
----SAWGFPKNGLL-------MPLLSVIFLSGNR------ASEK---DIWEFLNIL---
-----GIY-DGR----KHSVFGDPRKLITQDLVQE------KYLEYRQA-PDSDPPRFEF
----LWGPRAHAETS--KMRVLEFLAKVHDTVPS----A-FPFHYEE---ALRDEEERAR
AR-ATAAAASP-TQ----------------------------------------------
----------------------------------------------------------AD
--------------------ARS--Q-----------------------VKSS-LSSP--
P-----------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
--------------------------------------------------MLQTPE---S
R--------------------------------------------------GLPVP----
-------QAE----------------------------GEKDGGHDGETRAPT-----A-
-SQE-------------------RPKEELGA---------------GREE-G--------
----------------AAEPALTRKGA--RC-LAAKALARRRAYRRLNRTVAELV-----
-------QFLLVKDKKKSPIT-RSEMV--KYVIGDLK-----ALFPDIIARAAEH-----
----LRYVFGFE---------LKQ-FDRKH---------HTYI-----------------
-------L----------------------------------INKLKPLEEE----E---
EEEDLGGDGPRLGLL-------MMILGLIYMRGNS------AREA---QVWEMLHRL---
-----GMQ-PSK----YHFLFGYPKRLIMEDFVQQ------RYLSYRRV-PHTSPPEYEF
----SWGPRSNLEIS--KMKVLGFVAKLHKKEPQ----H-WPVQYRE---ALADEADRAR
AKAR-AEASMRARA--------SARA------D---------------------------
------------------------------------------------------------
-IH----L------W---------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------MAE-
----------------------------------------------------------GS
YS-----V-Q-------SENHSVEDMDEGSHEVR--EGGMAEGNDYE----EFGAFGGYG
TFTSFDIHI--LRAFGSLG-----------------------------PGLRILANEPWE
LENP-VLAQTLV-------EALQ--LDPETLANETAARAA-------------NVARSAA
---S----------NRA-ARAAA----------------RAAAAAARASFNQV---VTDH
-------------------------------------------------RVAT-------
------PQASGDNAQPTTYTE---AQ--------------------GATPETPLASPQIS
------QMFVTSEVAVPAAPAT-STQSQTAS---------------AAQ-----------
-------------EAA----------------TEGPSTACAFSQAPRASEVD-AARPKTA
FLGQ----------------------------NDVFD-------FTQPAGV---------
----SGMAFPRPKRPAPAQEA--ATEGPSA---------AS-GVPQAAPAREAAATRPKA
T-----------------------------K-----------------------------
------------------------------------------------------------
--------------------------------------------------------SGKA
LAKTRWVEPQNVVAAA--------AAKA-KMATS---------IPEPEGAAATAATAQHS
AE-----------------------P---------------------------------W
TRMGGKRTKKSKHLDDEY--------ESSE-EEREPPTVPQTWRASQPSVT---------
---------A----R---------------------------------------------
----------------------------------------TQLA----------------
-----------------PRPP-----------------------------V----A----
-PRSQIPSRHVLCLP-PRNVTLL---QERANKLVK------YLMIKD-YKKIPI--KR--
------------------------------------------------------------
----SDM---LKDVIREYDEHFPEIIERATYTLEKKFGIHLKEIDKEEHLYI-LICTRDS
SAR-LL-GKTKDT-PRLS---LLL----------VILGI----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPFLGDLRKLITDEFVKQK-------
---------YLEYKKIPNSSP---P--EYEFLWGLRARHETSKMRVLRFIAQNQNR---D
------PREWKAHFLEAVDDAFKTMDVDMA--EEHAR----AQMRAQMNIGDEAL-----
------IGR--WSWDDIQAELLT-WDEDGDFGDAWA-RIPF----AFWARYHQYILNSNR
ANRSA------TWRAGVSSGTNGGASTSVLDGPSTS-ST---IRTRNAARIG--------
----ASFFSWIQHR----------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
----------------------LGQVSTMFSEDDFQST---EGAPSGPQI----------
---------QWSQDLPRVQVFRE----------QANQE---DRSPR-RTQRITGG-EV--
-----------------LWGPITQIFPTVWPADLTGVIMPLEQ-----------------
-----------------RSQ-HCKPE-E----------------GLQA----QED-NPG-
-------------LVGGAQALQAE------------------------------------
-----------------------------------------------------------E
Q-E---------------------------------------------------------
------------------------------------------------------------
---AASFSSTLN----VGT--LEE------------------------------------
---------VP--------------------------------------ATES---PK--
--SSGESS---SPTAMD-S--IFGSLSDE----------------GSSS--QEEEGP---
------------S------TSPDLI------------DPESFSQDILHDKIIDLV-----
-------HLLLCKYRVKGLIT-KAEML--GSVIKNYE-----DYFPEIFREASEC-----
----MQLLFGID---------VKE-VDPTS---------HSYV-----------------
-------L----------------------------------VTSLSL-SYD----GIQG
---DE-QSMPKSGLL-------IIVLGVIFMEGNC------VPEE---VMWEVLSIM---
-----GVY-AGR----EHFLFGEPKKLLTHDWVQE------KYLVYRQV-PGTDPACYEF
----LWGPRAHAETS--KMKVLEYIANANGRDPS----S-YSSLYED---ALREEEEGV-
------------------------------------------------------------
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------------------------------------------------------------
--------------------------------------MPRGQK---SKLRAREKR-RQA
-RG-----ETQAL-----------------------------------------------
-EA-------------AQAMG---------------------------------------
------------------------------------------------------------
-ESS-------------------------SAACP-----P---------------SGGRC
---------------------------------AA-------T-------PCPAQG---T
P--SSVSADA-A------------------------------------------------
------------------------------------------------------------
-----------------LS----CTDSDEGA---------------RN-Q-DE-GSP---
------------------------------S-S--SDGAEVLCRDPLNKKVVLLV-----
-------QFLLHKYQKREPIT-KADML--KFVIKKYK------YFNEILKRASEH-----
----MELAFGVD---------LKE-VDPVR---------HCYT-----------------
-------L----------------------------------ISKLDL-TFE----STMH
----EEENTPKTGLL-------MIVLGVIFMKGSC------APEE---EVWEVLNMM---
-----GVY-AER----KHFIYGDPKKVITQDLVRL------KYLEYRQA-PGSEPPRFEF
----LWGPQAYAETS--KMRVLEFLAKVHDTVPS----A-FPSWYEE---ALKDEEERAR
AR-AAARAQTA-AM----------------------------------------------
----------------------------------------------------------AS
--------------------ARA--R-----------------------GLGR-QLLPV-
------------------------------------------------------------
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------------------------------------------

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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------MPRGQK---SKLRAREKR-RQA
-RT-----ETQGL-----------------------------------------------
-EV-------------AKATGAAA------------------------------------
-----------------------------------------------------------A
GKPH----------------------------SP-----V---------------FGDRP
ENLP-A------------------------AGTPS-------T-------PEAREG---A
T--GATAA----------------------------------------------------
------------------------------------------------------------
-----------------SS----GTNSAENI---------------NS-P-KA-ESA---
------------------------------S-F--PRGAESSLSEILSKKVVLLV-----
-------QFLLQKYQKREPIK-KADML--KFVIKQYK-----NHFNEILKRASDH-----
----MELAFGVD---------LKE-VDPTR---------HCYT-----------------
-------L----------------------------------VNKLDL-SYD----SALN
----EYEHMPKTGIL-------MIVLGVIFMRGNC------APEE---AIWEVLNMM---
-----GIY-AER----KHFIYGDPKKVLTEDLVQL------KYLEYRQV-ANSEPPCYEF
----LWGPRAHAETS--KMKVLEFLAKVHDTVPT----A-FPSWYQE---ALRDEEERAR
AR-AAARARTA-AL----------------------------------------------
----------------------------------------------------------AS
--------------------ARS--R-----------------------ARAS-TSSQAK
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------------------------------------------

------------------------------------------------------------
------------------MSL--VSQNSRRRRRRVAK---ATA-----------------
----------H-NSSWGEMQAPNAPGLPADVPGSDVPQGPSDSQILQ-GLCAS-------
---EG-----------------PST------------SVLPT------------------
---------------SAEGPST---------FVPPTIS---EASSASGQPTI-SEG-PGT
SVLPTP---------------S-EG----LSTSGPATIS---------------------
-----KGLCTSVTLAASEGRN------TSRPPTSSEEPST---SV-------PPTASEVP
-S----------------------TSLPPTPGEGTSTSVPPTA--------CEGPSTSVV
TTPDEAPRTS-------------------VPPTPGEGPGTS-------VP--LTAAEGLS
TSVPATPDEGPS--------TS---VP-----PTATEG------------LST---PVPP
T------RDEGPSTSVPATPGEGPSTSVLPAAS---------------DGQSIS------
------------------------------------------------------------
------------------------------------------LVPTPGKGSSTSVPPTAT
EGLSTSV---------QPTAGEGPSTSVP---------------PTPGGGLS--------
---------------------------------------------------------TSV
----------T-------------------------------------------------
------S---------VPPTAT--------------------------------------
-----------------------------------------------------------E
DLST--------------------------SVPP-----T---------------PGEGP
ST-SVLP-TPG------E-GLS-TSVPPT-ASD-GS--D---T-SVP---PT-PGE----
G--PSTLVQP----------------TAPDGP------------GPGSSVLPNP------
---GEGPSTLFSSSA-----SVDRNPSKCS-LVLPSPRVTKA------------------
----------------S------VDSDSEGP---------------K-------------
-------GAEGPIEFEVLRDCESPNSVSIMGLNTSRVAITLKPQDPMEQNVAELL-----
-------QFLLVKDQSKYPIR-ESEMR--EYIVKEYR-----NQFPEILRRAAAH-----
----LECIFRFE---------LRE-LDPEA---------HTYI-----------------
-------L----------------------------------LNKLGPVPFE-----GLE
----ESPNGPKMGLL-------MMILGQIFLNGNQ------AKEA---EIWEMLWRM---
-----GVQ-RER----RLSIFGNPKRLLSVEFVWQ------RYLDYRPV-TDCKPVEYEF
----FWGPRSHLETT--KMKILKFMAKIYNKDPM----D-WPEKYNE---ALEEDAARAF
AEG---------------------------------------------------------
------------------------------------------------------------
----WQALPHFRRPFFEE----------AAAE------------------VAS-PD----
-SE---------------------------------------------------------
---------VSSY-------------------------S---------------------
---------SKYAPH-SWHESRL---ESKARKLVQ------LFLLMD-STKMPI--PK--
------------------------------------------------------------
----KGI---LYYIGRECSKAFPTS-----------------------------------
------------------------------------------------------------
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--------------------------------------MTLGERN---------------
-----------------ELP---KHE-E----------------DHQD----PRE-VQR-
-------------PVDAQLSEAEE------------------------------------
-----------------------------------------------------------E
EEGLSPPSS------TY---------SPLFSG-------------------------SSP
SSSSS-------------------------------------------------------
-----SSYFALY----PGT--PEEG-----------------------------------
---------SA---------------------------------------AGS---PSPP
QSPLRACP---SPSALA-G--PPWSQSED----------------SF-ST-SDEERW---
------------G------TGVERE----------VAPPVAQEG--FHVKAVDLV-----
-------AFLLHKYRAKQPTS-KAEML--EVITPEYQ-----DDFPVIWGQASEC-----
----MQLVFGLD---------LIE-VDPIA---------HSYV-----------------
-------L----------------------------------VTVLGL-SYD----GMLS
-G--E-QGLPKTGLL-------VLLLGVILLEGDC------VPEE---KVWEAVGVI---
-----GVF-AGK----QHLIYGEPGDLLTHVWVQE------GYVEYRQV-AGSDPTRYEF
----LWGPRAYEETS--KLRVMEYLLHINSRQPA----Y-SPAQSKE---ERRSDEEEGA
------------------------------------------------------------
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--------------------------------------MENPD-----------------
-----------------NTH-YCSLQ-G----------------SARS----QRE-----
-------------LDNVQAT----------------------------------------
------------------------------------------------------------
--------------------------------------IAVV------------------
------------------------------------------------------------
---DEEE-ATPT----SKK--V--------------------------------------
----------Y--------------------------------------SSGI---PSPP
QSPQRASS---PLVILA-S--VPEG------------------------P-SEEAST---
------------N------QVEEQE------------DPLCMLYNAQNIKLYELA-----
-------TFLFFKYQMKAFTT-KAEML--ESIGREYE-----EYYPLIFSEASEC-----
----FKLVSGIG---------MIE-VDPFV---------QSYI-----------------
-------L----------------------------------VPALGL-TYD----GM--
LT-DV-QSKPKTGIL-------IVVLGAIFTQGNC------VSEE---IIWKMLNNI---
-----GLY-GGR----HLYIHQDPRKFISEEFVQE------GYLEYRQV-PNSDPPSYEF
----LWDPRAFAETT--KMKVLEIFASITMTDPR----A-YTEKYAE---ALRDETERAQ
ARIIQQIVLQL-------------------------------------------------
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---------------------------------------MDRRNDYGYRVPPFQ--G---
--------PLPPP--GSLGLP----------------------------FPPDIQTETTE
EDSV-LLMHTLL-------AATK--DSLAVDPPVVNRPKK-------------SKTKKAP
IKAI----------TKA-APA--APPVPTANEIATNKPKITLQALNLPVITQISQASPT-
T------------------------------------------------EVTN-------
------TQVSSVTAQPKKANKMKRVTAKAAQG-SQSPTGCEGGATQLKSPLQVLNLPVIS
QNIHA---SIANESASSQTL-ITSIKPKKAS---------------KAK-----------
-------------KAA----------------NKAIASATEVSLAPTATHTA-TTQGQIT
-NETASIHTTAASIRTKKASKARKIIA--KVINTDTE-------HIQAANV---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------TETAT
RQIEA--------------------S---------------------------------V
IAIRSQKSKGKKAASRGP---------N------------SVSEISEALLATQMVTNQAL
AATLRVKRGS----RARKA----STKARATESQT----PNADQGAQAKMASAQ-TNVSAL
ETQ------------VA------------AAVQALADDYLAQL----SLEPTTRTRGKRN
RK-----------------------------------------------SKHLNGDERS-
GNNYRRIPWGRRPAP-PRDVAIL---QERANKLVK------YLLVKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LRDVIQEYDEYFPEIIERASYALEKMFRVNLKEIDKQSSLYI-LISTRES
SAG-IL-GTTKDT-PKLG---LLM----------VILSV----------IF--------M
-NGNK----A-S--EAVIWEVLRKLGLH--PGVRHSLFGEVRKLITDEFVKQK-------
---------YLEYKRVPNSRP---P--EYEFFWGLRSYHETSKMKVLKFACKVQKK---D
------PKDWAVQYREAVEMEVQAAAVAVA--EAEAR----AEARAQMGIGEEAV-----
------AGP--WNWDDMDIDCLT-REELGDDAQAWS-RFSF----EIEARAQENADASTS
VNFSRGAGTRAGFSNGASISFNGAPSS--S----G-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------GPGITFGGAPSSSASFSNTASISFGGTLSTSS----------------
--------------------SFS------------------S----------------AA
SISFGGAPSTSTSFSSEASISFGGTPCTSASFSGGVSSSFSGPLN--TSATFSGAASSGF
GG------------------TL-STTAGFSSILSTSTSFGSAPTTNTVFSSALSTSTGFG
GTFSTSVCFGGSPSSSGSFGGTLSTSICFGGSPCTSTGFGG----TLSTSVSFGGPSSTS
ANCGGTLSTSICFDGSPSTG-AGFGGALNTSASFGSALNTS-------------------
-------------------------------------------------AGFGGAMSTSA
DFGSTLSTSVCFGGSPGTSVSFGSALNTSAGFGGAVSTSTDFGG----------------
------------------------------------------------------------
-----TLSTSVC------------------------------------------------
----------------------FGGSPSTSAGFSGALNTNASFGCAISTSAGFSGAVGTS
AGFSGVPSTNPGFGGAFNTSAGFGGALSTTTDFGGTPNNSIGFGAAPSTSVSFGGAHSTS
LCFGGAPSTSLCFGSASNTNLCFGGPPSTSACFSGATSPSFGDGPSTSTGFSFGNGLSTS
AGFGGGLNTSAGFGGGLGTSAGFSGD------------------------------LSTS
SGFDGGLGTSAGFSGGPGTSTGFGGGLGTSAGFSGGLGTGAGFGGGLVTSDGFGGGLGTN
ASFGSTLGTGAGFSGGLSTSDGFGSRPNASFDRGLSTIIGFGSGSNTSTGFIGEPSTSTG
FHSGPSSIVGFSGGPSTGVGFCSGPSI-SGFSGGPSTGAGFG------------------
------------------------------------------------------------
-------GGPNTGAGFGGG-PSTSAGFGSGATSLGACGFSYG

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------------------------------MPR---------------------------
----------------------GKKSK-------------------------------LH
--------------------TCDKRR-QAEHGTQD---LRGAQVTATTMEALS-SSSNP-
--------------------G-PGVDAKG-RSGARSGNHLKRPR-G-------------A
---------LTTT---P-------------VPASVSPTRSSKR-------------AIGE
TGKTHN SSLAPVSNV-RSGKHSL---TRPTNL LVQ------FLLRMY-KTRKPI--RK--
------------------------------------------------------------
----VNM---LKIIDKKYHNRFLRILKRASDSMEVVFGIDVKKDNTAKHSYV-LVSKMSL
PRNGIV-HRGRGF-PKTG---LLM----------NLLGV----------IF--------M
-KGNC----A-T--EEYIWDFLSKMNIY--AGKRHFIFGEPKKLITQDLVQLK-------
---------YLEYRQVPGSDP---A--CYEFLWGPRAHAETSKMRVLEFLARINRL---D
------PSAFHFWYEEALKDEEERAQANGC-PSVPPAVPSTP-SEAEANSALC-GS----
------------------------------------------------------------
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------------------------------MPR---------------------------
----------------------GKKAK-------------------------------LH
--------------------TCEKRR-QAQHGTQD---LRGTQVTATTMEALS-SSSSP-
--------------------G-PGVDAKR-KSGARSGNHLKRPR-G-------------A
---------LVTT---T-------------VPAGVSPTRSSKR-------------ALGK
IGKTRN SSQAPLSNV-RSGKHSL---TRPANL LVQ------FLLRMY-KTKKPI--RK--
------------------------------------------------------------
----ANM---LKIIDKKYHNRFLRILKRASDSMEVVFGIDVKKDNTAKHSYV-LVSKMNL
PRNGIV-HRGRGF-PKTG---LLM----------NLLGV----------IF--------M
-KGNC----A-T--EEDIWDFLGKMNIY--AGKRHFLFGEPKKLITQDLVQLK-------
---------YLEYRQVPGSDP---A--CYELLWGPRAHAETSKMRVLEFLARINRL---D
------PSAFHFWYEEALKDEEERAQASGC-PSVPPAVPSTP-SEAEANSALR-G-----
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--------------------------------------MPLG-K----------------
-----------------KNQ-CPEPK-Q----------------SLQA----QTE-APS-
-------------LGAAQVPLTEE------------------------------------
-----------------------------------------------------------G
A-----------------------------------------------------------
------------------------------------------------------------
---AFPSLSALI----QSI--TEAA---L---------------------AAG-------
----------I--------------------------------------SSVA-------
QNSQRACS---SSTAIK-A--TPSSKSTE----------------A-SSS-RE-EG----
-----------------PTTLQPPP------------NPGSLSTEVLQNKMTELV-----
-------RFLRNKYVTKEPIT-KAEML--ASVLSEHK-----DHFPEVFTRACDC-----
----METVFGIE---------VKE-VDPPG---------HSYE-----------------
-------L----------------------------------VKLLDL-TYD----GMLS
---D-DQGMPKTGLL-------VFILCIILVHGNS------APEE---VIWEMLNSL---
-----GVH-AGK----NDFIYGEPRKLITEDLVQE------KYLECRQV-PGSDPPRYEF
----LWGPRARAETT--KMKVLEFLARATGNEPT----A-FADCYED---ALKDERERAE
AGAGPGDG----------------------------------------------------
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--------------------------------------MPRGQK---SKLRAREKR-RQA
-RG-----GLEDL-----------------------------------------------
-ID-------------ALAILEEE------------------------------------
-----------------------------------------------------------E
-EYP-------------------------PSPSS-----C---------------LKDVS
QS-S-L------------------------DGTAN-------N-------PHGLWE---A
L--SISTSAT-A------------------------------------------------
------------------------------------------------------------
-----------------AS----HTRHTEGV---------------ND-Q-ME-ERP---
-----------------------------RC-TQDLAATDNFPRGPLGEKVIMLV-----
-------HYLLYKYQMKEPIT-KADML--RNVTHMCK-----SQFPVILRRASEH-----
----LELIFGLD---------LKE-VEPNK---------HIYV-----------------
-------L----------------------------------INKLDL-DCD----ARLS
----DETSVPKTGLL-------MTVLGIIFTKGNC------AAEE---EIWKVFNMM---
-----GLY-DGI----EHFIFGEPRKLLTKDLVKE------NYLEYQQV-PNSDPPRYQF
----LWGPRAHAETS--KMKVLEFLAKVNNTVPS----E-FSTWYTE---ALQDEEERAR
AR-VAAKARIS-AT----------------------------------------------
----------------------------------------------------------AG
--------------------ARS--K-----------------------VKSS-NSSQLQ
------------------------------------------------------------
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--------------------------------------MPRRHK---NKSHAHGKC-HQV
-QG-----NTQEA-----------------------------------------------
-QA-------------SAAAAPKE------------------------------------
-----------------------------------------------------------E
-CL--------------------------SSPYS-----A---------------PQGSL
PSSP-A-------------------------AGD----------------HQELQG---A
M--APSSPDA-G------------------------------------------------
------------------------------------------------------------
-----------------PS----CAGSDEGA---------------QG-P-EE-ESA---
-----------------------------GA-SQAAPATQSTRKDPLARKARILV-----
-------EFLLEKYTKKEPIT-QNAL---KIVSRKYR-----QHFPEILSTALER-----
----VELVFGLE---------MKE-VDRSR---------NICT-----------------
-------L----------------------------------ISKLNL-GGN---DCP-S
----GGGGVPKSGLL-------MVLLGVIFINGNR------ATEE---EIWEFLSML---
-----GIY-AGR----RHWIFGEPRRLITKDLVQK------GYLNYCQV-PNSDPPRYEF
----LWGPRACADTS--KMKVLEVLAKFHGRVPS----S-FPDLYDE---ALRDQAERTG
LR-GAARAPTM-AE----------------------------------------------
----------------------------------------------------------AS
--------------------APS--K-----------------------AKSR-SSSHI-
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--------------------------------------MPLEQ-----------------
-----------------RSQ-HCKPE-E----------------GLEA----QGE-ALG-
-------------LVGAQAPAIEE------------------------------------
-----------------------------------------------------------Q
E-T---------------------------------------------------------
------------------------------------------------------------
----ASSSSTLV----EVT--LGE------------------------------------
---------VP--------------------------------------AAES---PSPP
HSPQGAST---LPTTIN-Y--TLWSHSDE----------------GSSN--EEQEGP---
------------S------TFPDL---------------ETSFQVALSRKMAELV-----
-------HFLLLKYRAREPFT-KAEML--GSVIRNFQ-----DFFPVIFSKASEY-----
----LQLVFGIE---------VVE-VVRIG---------HLYT-----------------
-------L----------------------------------VTCLGL-SYD----GLLG
---DN-QIVPKTGLL-------IIVLAIIAKEGDC------APEE---KIWEELSVL---
-----EAS-DGR----EDSVFAHPRKLLTQDLVQE------NYLEYRQV-PGSDPACYEF
----LWGPRALVETS--YVKVLHHLLKISGGPHI----S-YPPLHEW---AFREGEE---
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--------------------------------------------------------MAE-
----------------------------------------------------------GS
FG-----V-Q-------SENYSVEDMDEGSDEVG--EEEMVEGNDYE----EFGAFGGYG
TLTSFDIHI--LRAFGSLG-----------------------------PGLRILSNEPWE
LENP-VLAQTLV-------EALQ--LDPETLANETAARAA-------------NVARAAA
---S----------NRA-ARAA--------------------AAAARSAFNQV---MASH
R-------------------------------------------------VAT-------
------PQVSGEDTQPSTYAT--EAQ--------------------GPTPEAPLASPQTS
------QMLVTSEMAAPGAPAT-SAQSQTGS---------------SAQ-----------
-------------EAA----------------TEGPSSACAFSRAPSASEVDTATRPNTA
FLGP----------------------------NDVFD-------FTQPAGV---------
----SGMAFPRPKRPAPAQEA--ATEGPSA---------AS-GVSQMGPGREVAATRPKT
T-----------------------------K-----------------------------
------------------------------------------------------------
--------------------------------------------------------SGKA
LAKTRWVEPQNVVAAA--------AAKA-KMATS---------IPEPEGAAA--ATAQHS
AE-----------------------P---------------------------------W
ARMGGKRTKKSKHLDDEY--------ESSE-EEREPPAVPPTWRASPPSLT---------
---------V----R---------------------------------------------
----------------------------------------AQLA----------------
-----------------PRPP-----------------------------V----A----
-PRSQIPSRHVLCLP-PRNVTLL---QERANKLVK------YLMIKD-YKKIPI--KR--
------------------------------------------------------------
----SDM---LKDVIREYDEHFPEIIERATYTLEKKFGIHLKEIDKEEHLYI-LVCTRDS
SAR-LL-GKTKDT-PRLS---LLL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPFLGDLRKLITDDFVKQKNLGLTEG
APLSVAHSWYLEYKKIPNSNP---P--EYEFLWGLRARHETSKMRVLRFIAQNQNR---D
------PREWKARFLEAVDDAFKKMDVDMA--EEHAR----AQMRAQMNIGDEAL-----
------IGR--WSWDDIQVELLT-WDEDGDFGDAWA-RIPF----AFWARYHQYILNSNR
ANRRA------TWRAGVSSGTNGGASTSVLDGPSTS-ST---IRTRNAARAG--------
----ASFFSWIQHR----------------------------------------------
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--------------------------------------MPVG-R----------------
-----------------RNE-LRKLE-E----------------APQD----PRE-AQR-
-------------LADAELLSVSS------------------------------------
------------------------------------------------------------
---S-----------------------S--------------------------------
------------------------------------------------------------
---SSSSYFVLF----PNT--PEE--ESA---------------------AG--------
----------G--------------------------------------SSPP---QSP-
---QRAFP---APSAME-A--SPWSLSED----------------S-SSS-AMEEGS---
------------G------TGGEPG------------VAEPVLHAALHVRAVSLV-----
-------GFLLQKFRTKQPTS-QAEML--AIVGEDEQ-----DAFPGILGQASEC-----
----MRLVFGVE---------VKE-VDPSE---------HSYV-----------------
-------L----------------------------------VTVLGL-TCD----AMLS
---GE-QGLPKTGLL-------VVLLGVILLEGDR------APEE---VVWEALGVM---
-----GVY-AGE----EHIIFGEPRELLTNVWVQE------GYLEYQQV-PGGDPARYEF
----LWGPRAHMETS--RVQVLEY------------------------------------
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-----------A--AETRE-----------------------------------------
------------------------------------------------------------
--------------------------G-------------------------------GL
P-----------------------I---LQ----------------AETEETP-------
------------------------GPHLQ-ESP------------HLQESPHLQESPQEN
---------LGA----------------------R-----VGG-------------APE-
PG---LTGKGA---R-VSAAQ-ALAQGPVVAELVR------FLLVKD-KRKSPT--PR--
------------------------------------------------------------
----SEM---GKYVIRDLEDLFPEISARAGHLR-YAFEFELKTAGPQA-TQI-LINKLKP
PEEEED-L-GGGG-PRLG---PLM----------MVLGF----------IH--------M
NQGNS----A-R--EAQVWEMLRRWRVW--PSRHLCLLGHPKRIIMEEFMQQQ-------
---------YLSYRQAPRTNP---L--LGCSFSWPLRNLETSKLEILGFVAKLHEK---E
------PQHWQVQYHEALA-----------GQVNRVRARARASAR----AGT--------
---HPC------------------------------------------------------
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------------------------------------------------------------
--------------------------------------MPRGQK---SKLRARERR-RQA
-RA-----EDQGF-----------------------------------------------
-GG-------------AQATAAVE------------------------------------
-----------------------------------------------------------E
-ESS-------------------------SSSLP-----V---------------SGGTP
SSSP-A-------------------------AGT----------------PQKSQR---A
Q--TA-SSSAAA------------------------------------------------
------------------------------------------------------------
-----------------TF----RTSSDES-------------------A-HE-ENA---
-----------------------------SS-SQAPPSSESSCKDPLIRKTGELV-----
-------KFLLYKYKIKEPIT-KAEML--KIVNNKYK-----KHFPEILQRTTEH-----
----LELVFGLD---------LKE-VNPSG---------RCYA-----------------
-------L----------------------------------VSKLDL-SDE---GGL-S
----GSTGFPKNGLL-------MPLLGMIFMNGNR------TTEE---EMWKFLNLL---
-----GVY-EGR----RHFIFGEPRKLITQDLVEQ------KYLEYRLV-PNSDPPCYEF
----LWGPRAHDETS--KMKVLEFWAKVNHSAPS----S-FQAQYEE---ALRDEEERAR
AR-AAARAAAS-AR----------------------------------------------
----------------------------------------------------------IR
--------------------SRA-------------------------------------
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--------------------------------------MPLEQ-----------------
-----------------RSQ-HCKPE-E----------------GLEA----QGE-ALG-
-------------LVGAQAPAIEE------------------------------------
-----------------------------------------------------------Q
E-T---------------------------------------------------------
------------------------------------------------------------
----ASSSSTLV----EVT--LGE------------------------------------
---------VP--------------------------------------AAES---PSPP
HSPQGAST---LPTTIN-Y--TLWSHSDE----------------GSSN--EEQEGP---
------------S------TFPDL---------------ETSFQVALSRKMAELV-----
-------HFLLLKYRAREPFT-KAEML--GSVIRNFQ-----DFFPVIFSKASEY-----
----LQLVFGIE---------VVE-VVRIG---------HLYT-----------------
-------L----------------------------------VTCLGL-SYD----GLLG
---DN-QIVPKTGLL-------IIVLAIIAKEGDC------APEE---KIWEELSVL---
-----EAS-DGR----EDSVFAHPRKLLTQDLVQE------NYLEYRQV-PGSDPACYEF
----LWGPRALVETS--YVKVLHHLLKISGGPHI----S-YPPLHEW---AFREGEE---
------------------------------------------------------------
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---------------------------------------MAQKMDCGAGLLGFQNPDA--
--CRAVCHPLPQPPASTLPLSAFPT-LCDPPYSQLRDPPPVLSCCCTPLRASLAPAEASV
EDSA-LLMQTLM-------EAIQ--IS-EAPPTNQA--TA--------------------
------------------------------------------A-----ASPQSSQPPTA-
N------------------------------------------------EMAD-------
------IQVSAAAARPKS------------------------------------------
-----------------------------AF---------------KVQ-----------
-------------NAT----------------TKGPNGVYDFSQAHNAKDVP-NTQPKAA
V-------------------KSQNATP--KGPNAAYD-------FSQAATT---------
----GELAANKSEMAFKAQNAT-TKVGPNA---------T-YNFSQSLNANDLANSRPKT
------------------------------------------------------------
----------------------------------------------PFKAWNDTTKSPTA
-------------------------------DTQT-----------QNV-----------
----NQA---KMATSQ--------ADIETD--PG---------ISESDGATAQTSADGSQ
AQNLE--------------------S---------------------------------R
TIIRGKRTRKINNLNV---------EENSSGDQRRAPLAAGTWRSAPVPVTT-QNPPGAP
PNVLWQTPLA----WQNPS----GWQNQTARQTP----P-ARQSPPARQTPPAWQNPVAW
QNPVIWPNPVIWQNPVIWPNPI-VWPGPVVWPNPLAWQNPPGWQTPPGWQTPPGWQGPPD
WQG---PPDWPLPPDW-PLPP-DWPLP-TDWPLPPDWIPADWPIPPDWQNLRPSPNLRP-
-SPNSRASQNPGAAQ-PRDVALL---QERANKLVK------YLMLKD-YTKVPI--KR--
------------------------------------------------------------
----SEM---LRDIIREYTDVYPEIIERACFVLEKKFGIQLKEIDKEEHLYI-LISTPE-
SLAGIL-GTTKDT-PKLG---LLL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPLLGDLRKLLTYEFVKQK-------
---------YLDYRRVPNSNP---P--EYEFLWGLRSYHETSKMKVLRFIAEVQKR---D
------PRDWTAQFMEAADEALDALDAAAA--EAEAR----AEARTRMGIGDEAV-----
------SGP--WSWDDIEFELLT-WDEEGDFGDPWS-RIPF----TFWARYHQNARSRFP
QTFAG---------------------P--IIGPGGTASA------NFAANFGAIGF----
--------FWVE------------------------------------------------
------------------------------------------------------------
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---------------------M-------SLVSQNACH----------------------
------------------------------------------------------------
------------------RSLETT------------------------------------
-----------------------------------------------------------A
-DY---------------------------------------------------------
-----------------------------------------------------------S
D--FQVDMRS----------------TNASGP------------P-T-------------
---------------------------------------------------SM------L
----------VPNAPQ----GPQGPIGPQDA---------------STSQ-AA-------
---------QDP----N--DLEV--LID-EQSRRLGA---LRVHDPLEDRSIALV-----
-------NFMRMKSQIEGSIQ--QTEM--LEFLREYS-----DQFPEILRRASAH-----
----LDEVFGLN---------LRV-LDPQA---------DTYN-----------------
----------------------L-------------------ISKRGL-QTT----DRIA
----ESLDMPKASLL-------ALVLGHILLNGNR------SREA---SIWDLLLKV---
-----DVL---DEPQRINIPFGNTRNLLTTDFVRM------GFLEYWPV-YGTNPLEFEF
----LWGSRAHR--EITKM-----------------------------------------
------------------------------------------------------------
--------------------------E-------------------------------AL
K-----------------------F---VA----------------EAHDEEP-------
------------------------WSWPE-EYN------------KALEADKAKER---S
---------------------------------------------------------EA-
AG---L--------E-FWSED---TMNDKANDLVQ------LAINVT-EELLPI--HQ--
------------------------------------------------------------
----DEL---LAHTGKEFEDVFPNILSRAILILDLFYGFSLIEVDTSEHIYL-LVQQPES
EEEQMM-LESLGR-PTQE---YVM----------PILGL----------IF--------L
-MGNR----V-K--EANVWNLLRRFGVD--VGRKHAI--------TCKLMRQR-------
---------YLECRPLSYSNP---V--EYELLWGPRAHLETTKMKALEYMAKLYKK---R
------PQDWPEQYREAVE-----------DEEARARSEATAMFF----FSP--------
---M--------------------------------------------------------
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---------------------------------------MDRRNDYGYRVPLFQ--G---
--------PLPPP--GSLGLP----------------------------FPPDIQTETTE
EDSV-LLMHTLL-------AATK--DSLAMDPPVVNRPKK-------------SKTKKAP
IKTI----------TKA-APA--APPVPTANEIATNKPKITWQALNLPVITQISQALPT-
T------------------------------------------------EVTN-------
------TQASSVTAQPKKANKMKRVTAKAAQG-SQSPTGHEGGTIQLKSPLQVLKLPVIS
QNIHA---PIANESASSQAL-ITSIKPKKAS---------------KAK-----------
-------------KAA----------------NKAIASATEVSLAATATHTA-TTQGQIT
-NETASIHTTAASIRTKKASKARKTIA--KVINTDTE-------HIEALNV---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------TDAAT
RQIEA--------------------S---------------------------------V
VAIRPKKSKGKKAASRGP---------N------------SVSEISEAPLATQMVTNQAL
AATLRVKRGS----RARKA----ATKARATESQT----PNADQGAQAKMASAQ-TNVSAL
ETQ------------VA------------AAVQALADDYLAQL----SLEPTTRTRGKRN
RK-----------------------------------------------SKHLNGDERS-
GSNYRRIPWGRRPAP-PRDVAIL---QERANKLVK------YLLVKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LRDVIQEYDEYFPEIIERASYTLEKMFRVNLKEIDKQSSLYI-LISTQES
SAG-IL-GTTKDT-PKLG---LLM----------VILSV----------IF--------M
-NGNK----A-S--EAVIWEVLRKLGLR--PGVRHSLFGEVRKLITDEFVKQK-------
---------YLEYKRVPNSRP---P--EYEFFWGLRSYHETSKMKVLKFACKVQKK---D
------PKDWAVQYREAVEMEVQAAAVAVA--EAEAR----AEARAQMGIGEEAV-----
------AGP--WNWDDMDIDCLT-REELGDDAQAWS-RFSF----EIEARAQENADASTN
VNFSRGASTRAGFSDGASISFNGAPSS--SGGFSG-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------GPGITFGVAPSTSASFSNTASISFGGTLSTSS----------------
--------------------SFS------------------S----------------AA
SISFGGAPSTSTSFSSEASISFGGMPCTSASFSGGVSSSFSGPLS--TSATFSGGASSGF
GG------------------TL-STTAGFSGVLSTSTSFGSAPTTSTVFSSALSTSTGFG
GILSTSVCFGGSPSSSGSFGGTLSTSICFGGSPCTSTGFGG----TLSTSVSFGGSSSTS
ANFGGTLSTSICFDGSPSTG-AGFGGALNTSASFGSALNTS-------------------
-------------------------------------------------TGFGGAMSTSA
DFGSTLSTSVCFGGSPGTSVSFGSALNTNAGFGGAATYDLTFVV----------------
------------------------------------------------------------
-----LLSTSVC------------------------------------------------
----------------------FGGSPSTSAGFGGALNTNASFGCAVSTSASFSGAVSTS
ACFSGAPITNPGFGGAFSTSAGFGGALSTAADFGGTPSNSIGFGAAPSTSVSFGGAHGTS
LCFGGAPSTSLCFGSASNTNLCFGGPPSTSACFSGATSPSFCDGPSTSTGFSFGNGLSTS
AGFGGGLNTSAGFGGGLGTSAGFSGG------------------------------LSTS
SGFDGGLGTSAGFGGGPGTSTGFGGGLGTSAGFSGGLGTSAGFGGGLVTSDGFGGGLGTN
ASFGSTLGTSAGFSGGLSTSDGFGSRPNASFERGLSTIIGFGSGSNTSTGFTGEPSTSTG
FNSGPSSIVGFSGGPSTGVGFCSGPST-SGFSGGPSTGAGFG------------------
------------------------------------------------------------
-------GGPNTGAGFGGG-PSTSAGFGSGAASLGACGFSYG

------------------------------------------------------------
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---------------------------------------MSDT-----------------
---------------SK-SGA----------------------------GPARFQAKASE
KNSS-STMQTLL-------TVTQ--NLDVSETPKGS------------------EA----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------AKVSKASGVS-------KATEVS---------------KAT-----------
-------------EI---------------------------SKASKAQESA-TTKASPT
TTKLTDAQVLAA----EK--KSPAADT--KTQNADLQ-------AVTVPAT---------
----ETKK-----ASC--------------------------------------------
------------------------------------------------------------
--------------------------------------------------------VA--
-------------------------------DTKV-------------------------
----N-T--KALETET--------ATSQAPADEP---------EP--EGAAAQVQENQDT
RPKVK--------------------A---------------------------------K
KARKVKHLDGEEDGN---------------SDQSQASGTTGGRRVSKALMASMARRASRG
PIAFWARRAS----RTRLA----A------------------------------------
------------------------------------WARRALL----SLRSPKARRGKAR
RRA---------------------------------------------------------
-AKLQS-SQEPEAPP-PRDVALL---QGRANDLVK------YLLSKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LKDIIKEYTDVYPEIIERAGYSLEKVFGIQLKEIDKNDHLYI-LLSTLEP
TDAGIL-GTTKDS-PKLG---LLM----------VLLSI----------IF--------M
-NGNR----S-S--EAVIWEVLRKLGLR--PGIHHSLFGDVKKLITDEFVKQK-------
---------YLDYARVPNSNP---P--EYEFFWGLRSYYETSKMKVLKFACKVQKK---D
------PKEWAAQYREAMEADLKAAAEAAA--EAKAR----AEIRARMGIGLGSE-----
----NAAGP--CNWD-------------EADIGPWA-KARIQAGAEAKAKAQESG--GAS
AAASTST----------GTGAGASASA--SGGFSASASLTATLTFGLFAGLGGAGASTSS
SSGACG-FSYK-------------------------------------------------
------------------------------------------------------------
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--------------------------------------MSLEQ-----------------
-----------------KSQ-HCKPE-E----------------GVEA----QEE-ALG-
-------------LVGAQAPATEE------------------------------------
-----------------------------------------------------------K
E-A---------------------------------------------------------
------------------------------------------------------------
---AASSSSPLV----PGT--LEE------------------------------------
---------VP--------------------------------------AAGS---TGPP
QSPQGASA---LPSTVN-F--TCWRQPNE----------------GSSS--QEEEGP---
------------S------TSPDP---------------ESLFREALSKKVDELV-----
-------HFLLLKYRAKELVT-KAEML--ERVIKNYK-----HCFPVIFGKASES-----
----LKMIFGID---------VKE-VDPTS---------NTYT-----------------
-------L----------------------------------VTCLGL-SYD----GLLG
---GN-HIFPKTGLL-------IIVLGTIAMEGDS------ASEE---EIWEELSVM---
-----DVY-DGR----EHSVYGEPRKLLTQEWVQE------NYLEYRKV-PGSDPARYEF
----LWGPRALAETS--YVKVLEHVVRVNARVRI----S-YPSLREA---ALREEEEGV-
------------------------------------------------------------
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------------------------------------------

------------------------------------------------------------
------------------MSL--VSQNSRRRRRRGAK---ATA-----------------
----------QSSSSWGEIQATNAPGLPAAMPGPDIPQDPSDPQSLQ-GLCAS-------
---ES-----------------PST------------SVLPT------------------
---------------PSKGPRT---------SVPPTAS---EGSSTSRPPTI-SKG-PN-
------------------------------------------------------------
---------TSVTLTASEGQS------ASGPRTCTEEPSS---FV---------------
---------------------------LPIPG--------------------EGPSTFVL
LTATEGSGTS-------------------VPPLPGEGLNTS-------VP--LTGSEGPG
TS-------------------------------------------------------MRP
P------PAEGPSTSVPPTSGESPSTSVLPIAS---------------EAPGT-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------SVPP-----P---------------PGEGP
SN-SVLP-IAF------E-GIS-G--LPT-ASE-GP--G---I-FVP---PP-PGE----
D--PSTSVLP----------------TASEGP--------------STSKPPTP------
---GEGPSTPLNSSA-----SVGRNPSKCP-VVLPSTREAKA------------------
----------------S------VDSDSEGP---------------R-------------
-------GAVGPVEFEVVRDCERPNSITIMGLSTSRVAVTLKPQDPIEQNVAELL-----
-------QFLLVKDQSKYPIR-ESEMR--EYIVKEYR-----SQFPEILRRAAAH-----
----LECIFRFE---------LRE-LDPEA---------HTYI-----------------
-------L----------------------------------LNKLGPVPFE-----GLE
----ESPNGPKMGLL-------MMILGQIFLSGNQ------AKEA---EIWEMLWRM---
-----GVQ-RER----RLSIFGNPKRLLSVEFVWQ------RYLDYRPV-TDCNPVEYEF
----FWGPRSHLETT--KMKILKFMAKIYNKDPM----D-WPEQYNE---ALEEDAARAL
AEG---------------------------------------------------------
------------------------------------------------------------
----WQALPHFRRPFFEE----------AAAE------------------VAS-AD----
-SE---------------------------------------------------------
---------VSNY-------------------------S---------------------
---------SKYPPH-SWPESRL---ESKARKLVQ------LFLLMD-STKLPI--PK--
------------------------------------------------------------
----KGI---LYYIGRECSKVFPDLLNRAARTLNHVYGTELVVLDPRNHSYT-LYNRREM
EEIEEI-VDSPNR-PGNN---FLM----------QVLSF----------IF--------I
-MGNH----A-R--ESAVWAFLRGLGVQ--SGRKHVI--------TCRYLSQR-------
---------YIDSLRVPDSDP---V--QYEFVWGPRARLETSKMKALRYVARIHRK---E
------PQDWPEQYREALEDEANRADVGHR-QF----------FVHNFR-----------
------------------------------------------------------------
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------------------------------------------

------------------------------------------------------------
------------------MSQ--LSKNLGDSSPPAEAPKPP-------------------
----------VYSRPTVLMRAP-----PASSRAPPVPWDPPPIDLQA-SLAAWQAPQPAW
EAPQGQLPAPV---VPMTQPPALGGPIVPAPPLGGPMGKPPT------------------
---------------PGVLMVHP-PPPGAPMAQPPTPGVLMVHPSAPGAPMAHPPP-PGT
PMSHPP-------------------------PPGTPMAH---------------------
-----P---------P------------------PPGTPM----A-------HPPPPGTP
------------------------MAHP--PPPGTPMVHPPPPGTPMVHPPPPGTPMAHP
PPPGTP--MA-------------------QPLPPGTPMAQP---PAPGVLMAQPLTPGVL
MVQPA-------------APGAPMVQPP----PAAVM-------------------TQPP
PSGAPMAKPPGPGVLMIHPPGARAPMTQPPASG---------------APMAQPAAPPAQ
PMAPPAQPMASWAPQAQPLILQIQSQVI----R-------APQQV---P-----------
-------Q---GPQAPPAQLATPPGWQATSPGWQATPQGWQATPLTWQTTQVTWQAPA--
----------IAWQVPPPV-RQGPPPIRP-------------GPPPIRPGPPPVR---QA
PPVIRQ---APPVIRQA--------PPVIRQAPPVIRQAPPVIRQAPPVIRQAPPVIRQA
-PP---------V-----------------------------------------------
--------IRQAPPVIRQAPP-PI------------------------------------
-----------------------------------------------------------R
--------------RAPQVLATQPPLWQALPPPP-----P---------------LRQAP
QARLPAPQVQA------------APQVPTAPPATQ-------VPAAPLAGPQVPQP---V
L--PAPLSAP----------------------------------------LSA-------
----------P-----------QAVH--CPSIIWQAPKDQPPVPHE--------------
------------------------------------------------------------
------------------------------------------------------------
---------IPTSMEFQEVQQ-TQ-AL--AWQAQKAP-----THFWQPLPAQEAQRQ---
----APPMVPLE-------QPFQGAPPCQKAVQIQL-PPQPPQTS--GPQAELPTLQLQP
SWQTPPAVLQAQPGPPLAAANFPLGSAKSLMTP-SGESRASPIDRRGSS-KE----RRTS
SK--ERRAPSKDRM----------IFAATFCAPKA----VSAARAHLPGTWKNLPATPET
FAPSSSVF-PAT----SQFQPASLNAFKGPSAASE----APKSLPYAL---QDPFACVEA
LPAVPWAPQPNMNASKASQAVPTLLM-ATAAAPQ----A-TATT-QE---ASKTSVEMPR
RS-----------------------GKA--------------------------------
--TRK-----KKHLEARE-DSRGHTLA-------------------------------FH
--D-WQGP----RPWENLN--LSDW--EVQSPVQ-V--LGDWEHPNTPRGLSGWEGPSTS
-RI---------------LSG---WEGPSTSWALSAWEGPSTSR-A--------------
---------LGLS---------------ESPRSPLPLVVSEVA-------------G---
VSPGSSATQDNSKVE-AQSLSPL---DERANALVQ------FLLVKD-QAKVPV--QR--
------------------------------------------------------------
----SEM---VKVIIREYKDECLEIINRANNKLECAFGYQLKEIDTKNHAYI-IINKLGY
PTGDLV-ASYLDR-PKFG---LLM----------VVLSL----------IF--------M
-KGNC----V-R--EDLIFNFLFRLGLD--VRETNGLFGNTRKLITEVFVRQK-------
---------YLEYRRIPYTEP---A--EYEFLWGPRAFLETSKMLVLRFLAKLHKK---D
------PRCWPFHYLEALAECEWEDTDEDE-PDS--S--DSA-------RGP--------
---TSRPPPR--------------------------------------------------
------------------------------------------------------------
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--------------------------------------MPRGQK---STLHAREKR-QQT
-RG-----QTQDH-----------------------------------------------
-QG-------------AQITATNK------------------------------------
-----------------------------------------------------------K
-KVS-------------------------FSSPL-----I---------------LGATI
QKKS-A------------------------GRSRS-------A-------LKKPQR---A
L--STT-TSV-D------------------------------------------------
------------------------------------------------------------
-----------------VS----YKKSYKGA---------------NS-K-IE-KKQ---
-----------------------------SF-SQGLSSTVQSRTDPLIMKTNMLV-----
-------QFLMEMYKMKKPIM-KADML--KIVQKSHK-----NCFPEILKKASFN-----
----MEVVFGVD---------LKK-VDSTK---------DSYV-----------------
-------L----------------------------------VSKMDL-PNN----GTVT
----RGRGFPKTGLL-------LNLLGVIFMKGNC------ATEE---KIWEFLNKM---
-----RIY-DGK----KHFIFGEPRKLITQDLVKL------KYLEYRQV-PNSNPARYEF
----LWGPRAHAETS--KMKVLEFWAKVNKTVPS----A-FQFWYEE---ALRDEEERVQ
AA-AMLNDGSS-AM----------------------------------------------
----------------------------------------------------------GR
--------------------KCSKAK-----------------------ASS---SSHA-
------------------------------------------------------------
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---------------------------------------MAQKPDGGAGLRGYQA-----
--------------------------------------------------------EASV
EDSA-LLVQTLM-------EAIQ--IS-EAPPTNQA--TA--------------------
------------------------------------------AASGQNVSPQSSQPPTA-
N------------------------------------------------QVAD-------
------TGVSTAAARPKT------------------------------------------
-----------------------------GF---------------RAQ-----------
-------------NTF----------------SKGPN---DFSHARNAKEMS-KNQSKAA
Y-------------------KSHNGTS--KGPNAASN-------FSHGATT---------
----GKSAAKKSEIAFKVQNTT-TKAGPGA---------T-YNFSQSPSANEMINNQPKT
------------------------------------------------------------
----------------------------------------------ATKAWNDTTKVPAA
-------------------------------DAQI-----------QNV-----------
----NQA---KMANVG--------T------SPG---------ISETGGAAAQTSADGSQ
AQNVE--------------------S---------------------------------R
TIIRGKRTRKINNLNV---------EENSSGDQRRASLASGNWRSAPVPVTT-QNPPGAP
PNVLWQTPLA----WQNPS----GWQNQTARQAQ----P-ARQNPPARQTATAWQNPVAW
QNPVIWPNPVIWQNPVIWPNPI-VWPGPIVWPNPMAWQNAPGWQTPPSWQAPPSWQGPQD
WQG---PPDWQIPPDW-SLPP-DWSFS-TDWPFPPDWIPADWPIPPDWQNLRPSPNLRS-
-TPNARASQNQGAPQ-PRDVALL---QERANKLVK------YLMLKD-YTKVPI--KR--
------------------------------------------------------------
----SEM---LRDIIREYTDVYPEIIERACFVLEKKFGIQLKEIDKEEHLYI-LISTPE-
SLAGIL-GTTKDT-PKLG---LLL----------VILGI----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPLLGDLRKLLTYEFVKQK-------
---------YLDYRRVPNSNP---P--EYEFLWGLRSYHETSKMKVLRFIAEVQKR---D
------PRDWTAQFMEAADEALDALDAAAA--EAEAR----AEARTRMGIGDEAV-----
------SGP--WSWDDIEFELLT-WDEEGDFGDPWS-RIPF----TFWARYHQNARSRFP
QAFTG---------------------P--IIGPSGTATA------NFAANFGAIGF----
--------FWVE------------------------------------------------
------------------------------------------------------------
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--------------------------------------MLPGQ-----------------
-----------------KSQ-PYKAE-E----------------GLQA----QGE-APG-
-------------LMDVQIPTAEE------------------------------------
-----------------------------------------------------------Q
K-A---------------------------------------------------------
------------------------------------------------------------
----ASSSSTLI----MGT--LEE------------------------------------
---------VP--------------------------------------DSGS---PSPP
QSPEGASS---SMTVTD-S--TLWSQSNE----------------DSSS--NEEEGP---
------------S------TSPDPA------------HLESLFREALDEKVAELV-----
-------RFLLRKYQIKEPVT-KAEML--ESVIKNYK-----NHFPDIFSKASEC-----
----MQVIFGID---------MKE-VDPAG---------HSYI-----------------
-------L----------------------------------VTCLGL-SYD----GLLG
---DD-QSTPKTGLL-------IIVLGMILMEGSR------APEE---AIWEALSVM---
-----GLY-DGR----EHSVYWELRKLLTQEWVQE------NYLEYRQA-PGSDPVRYEF
----LWGPRALAETS--YVKVLEHVVRVNARIRI----S-YPSLHEE-----ALGEEKGV
------------------------------------------------------------
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--------------------------------------MPRGQK---SKLRAREKR-RQA
-RE-----EPGHL-----------------------------------------------
-VA-------------AQATVPEE------------------------------------
-----------------------------------------------------------E
-ESS-------------------------SSLSP-----H---------------FKDAP
QSSP-A------------------------TGTPS-------K-------PQVTGR---V
H--STSTTAA-A------------------------------------------------
------------------------------------------------------------
-----------------AS----NTSFNEGA---------------NN-Q-VE-EKP---
-----------------------------NA-SQARNTTEHWQRGPLDKKVTMLV-----
-------YYLLYKYQMKEPIT-KADML--RNVIQTYK-----NHFHEILQKASEH-----
----LELVFGLD---------VKE-VDPNR---------NTYV-----------------
-------L----------------------------------VNKLES-SCD----GSIN
----DNGGVPKTGLL-------MTVLGVIFTKGNC------ATEE---QVWEVLNMM---
-----GVY-DGM----KNFIYGEPRKLITEDWVKE------EYLKYRQV-ANSDPPRYEF
----LWGPRAHAETS--KMKVLEFVAKIHDTVPS----A-FPAWYEE---ALRDEEEQTQ
AR-VVAKACTA-GM----------------------------------------------
----------------------------------------------------------AS
--------------------ARS--R-----------------------AMPS-SFSSPK
------------------------------------------------------------
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------------------------------------------------------------
--------------------------------------MSHS-Q----------------
-----------------KRQ-HS------------------------------KN-KQG-
-------------LVDTEVPAAGT------------------------------------
-----------------------------------------------------------S
E-----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------V--------
-SDPGAC----SSTALA-A--ASTSTPGE----------------G-SRY-KEEEVP---
------------------STSRKSP------------ESEALLGDTLDKKVVDLV-----
-------QFLSVKYITKKPIT-KAEML--KMAGKEYE-----DQFPVIFKKACEC-----
----LEVVFGID---------VKK-VDPAS---------HSYV-----------------
-------L----------------------------------TKTLDL-TYD----GILS
---D-DQGIPKTGFL-------ILILGVIFIEGNR------VPEE---KLWEVLNMI---
-----GVY-SGT----KDFLYGEPRKFITKDLVQE------GYLDYQQV-PNSDPPCYEF
----LWGPRAYAETS--KMKVLKFFAKVNGVDAS----A-FPPWYEE---ALRDEEERAR
ARIAATGGTTA-------------------------------------------------
------------------------------------------------------------
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---------------------------------------MDRRNDYGYRLPPFQ--G---
--------PLPPP--GSLGLP----------------------------FPPDLQTETTE
EDSV-LLMHTLL-------AATK--DPLAMDPPVVNRPKK-------------SKTKKAP
IKAI----------TRA-APA--APPVPTASEIATNKPKITLQALNLPVITQISQASPT-
T------------------------------------------------EVAN-------
------TQASSVTSQPKKANKMKRVTAKSAQG-SQSPAGYEGVTTQFKSPLQVLNLPVIS
QNIHV---PVANESASSQAL-ITSIKPKKAF---------------KAK-----------
-------------KVA----------------NKAIASATEVSLTPNATHTA-ITQGQIT
-SETASIHTTAASIRTKKASKAKKTTA--KVINTDTE-------HVEARNV---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------TEAAT
RQIEA--------------------S---------------------------------V
VAIRPKKSKGKKAASRGP---------N------------SLSEISEAPLATQMVTNQAL
AATLRVKRGS----RARKA----ATKSRATESQT----PVADQGSQAKMATAQ-TNVSAL
QTQ------------VA------------AAVQALADDYLAQL----SLEPTTRTRGKRN
RK-----------------------------------------------SKHLNGDERS-
GSNYRRIPWGWRPAP-PRDVAIL---QERANKLVK------YLLVKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LRDVIQEYDEYFPEIIERASYALEKMFRVNLKEIDKQSSLYI-LISTQES
SAG-IL-GTTKDT-PKLG---LLM----------VILSV----------IF--------M
-NGNK----A-S--EAVIWEVLRKLGLR--PGVRHSLFGEVRKLITDEFVKQK-------
---------YLEYKRVPNSRP---P--EYEFFWGLRSYHETSKMKVLKFACKVQKK---D
------PKDWAVQYREAVEMEVQAAAVAVA--EAEAR----AEARAQMGIGEEAV-----
------AGP--WNWDDMDIDCLT-REELGDDAQTWS-RFSF----EIEARAQENADASTN
VNFSRGASTRAGFSDGASISFNGAPSS--SGGFSG-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------GPGITFGGAPSTSASFSSTASISFGGTLSTSS----------------
--------------------SFS------------------N----------------AA
SSSFGGAPSTSTSFSSESSISFGGMPCTSASFSGGVSSSFSGPLS--TSATFSGGVNSGF
GG------------------IL-STTAGFSGVLSTSTSFGSAPTTSTVFSSALSTSTGFG
GTLSTSVCFGGSPSSSGSFGGTLSTSICFGGSPCTSTGFGG----TLSTSVSFGGSSSTS
ANFGGTVSTSICFDGSPSTG-AGFGGALNTSASFGGALNTS-------------------
-------------------------------------------------AGFGGAMSTCA
DFGGTLSTSVCFGGSPCTSVSFGGALNTNAGFGGAISTSTDFGG----------------
------------------------------------------------------------
-----ILSTSVC------------------------------------------------
----------------------FGGSPSTSAGFGGALNTNASFGCAVSTGAGFSGAVSTS
AGFSGAPSTNPGFGGAFSTSAGFSGALSTTTDFGGTPSNSIGFGAAPSTSVSFGGAHSTS
LCFGGAPSTSLCFGSASNTNLCLGGPPSTSACFSGATSPSFGDGPSTSTGFSFGNGLSTS
AGFGGGLSTSAGFGGGLGTSAGFSGS------------------------------VSTS
SGLDGGLGTSAGFSGGPGTSTGFGGGLGTSAGFSGGLGTSAGFGGGLVTSGAFGGGLGTN
ASFGSTLGTSAGFSGGLSTSDGFGSRPNASFNRGLSTIIGFGSGSNTSTGFTGEPSTSTG
FNSGPSSIVGFSGGPSTGVGFCSGPST-SGFSGGPSTGAGFG------------------
------------------------------------------------------------
-------GGPNTGAGFGGG-PSTSVGFGSGAASLGACGFSYG

------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------MAE-
----------------------------------------------------------GS
FS-----V-Q-------SESYSVEDMDEGSDEVR--EEEMVEGNDYE----EFGAFGGYG
TLTSFDIHI--LRAFGSLG-----------------------------PGLRILSNEPWE
LENP-VLAQTLV-------EALQ--LDPDTLANETAARAA-------------NVARAAA
---S----------NRA-ARAA--------------------AAAARTAFTQV---VASH
R-------------------------------------------------VAT-------
------PQVSGEDTQPTTYAA--EAQ--------------------GPTPEPPLASPQTS
------QMLVTSEMAAPGAPVT-STKSQTGS---------------PAQ-----------
-------------EAA----------------TEGPSSACAFSQAPCAREVD-TTRPSTA
FLGQ----------------------------NDVFD-------FTQPAGV---------
----SGMAFPRPKRPAPAQEA--ATEGSSA---------AS-GVPQTGPGREVAATRPKT
T-----------------------------K-----------------------------
------------------------------------------------------------
--------------------------------------------------------SGKA
LAKTRWVEPQNVVAAA--------AAKA-KMATS---------IPEPEGAAA--ATAQHS
AE-----------------------P---------------------------------W
ARMGGKRTKKSKHLDDEY--------ESSE-EEREPPAVPPTWRASQPSLT---------
---------V----R---------------------------------------------
----------------------------------------AQLA----------------
-----------------PRRP-----------------------------V----A----
-PRSQIPSRHVLCLP-PRNVTLL---QERANKLVK------YLMIKD-YKKIPI--KR--
------------------------------------------------------------
----ADM---LKDVIREYDEHFPEIIERATYTLEKKFGIHLKEIDKEEHLYI-LVCTRDS
SAR-LL-GKTKDT-PRLS---LLL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPFLGDLRKLITDDFVKQKNLELREG
TPLSVAPSWYLEYKKIPNSNP---P--EYEFLWGLRARHETSKMRVLRFIAQNQNR---D
------PREWKAHFLEAVDDAFKTMDVDMA--EEHAR----AQMRAQMNIGDEAL-----
------IGR--WSWDDIQVELLT-WDEDGDFGDAWA-RIPF----AFWARYHQYILNSNR
ANRRA------TWRAGVSSGTNGGASTSVLDGPSTS-ST---IRTRNAARAG--------
----ASFFSWIQHR----------------------------------------------
------------------------------------------------------------
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------------------------------------------

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--------------------------------------MADSR-----------------
-----------------NTQ-YCSLQ-E----------------SAQA----QQE-----
-------------LDNDQET----------------------------------------
------------------------------------------------------------
--------------------------------------METS------------------
------------------------------------------------------------
---EEEE-DTTT----SNK--V--------------------------------------
----------Y--------------------------------------GSGI---PSPP
QSPQRAYS---PCVALA-S--IPDS------------------------P-SEEASI---
------------K------GSGGLE------------DPLYLLHNAQNTKVYDLV-----
-------DFLVLNYQMKAFTT-KAEML--ESIGREYE-----EYYPLIFSEASEC-----
----LKMVFGLD---------MVE-VDPSV---------HSYI-----------------
-------L----------------------------------VTALGI-TYD----GM--
MT-DV-QGMPKTGIL-------IAVLSVIFMKGNY------VSEE---IIWEMVNNI---
-----GLC-GGR----DPYIHKDPRKLISEEFVQE------GCLKYRQV-PNSDPPSYGF
----LWGPRAFAETS--KMKVLQFFASINKTHPR----A-YPEKYAE---ALRDEIYRTK
AWILNRCSNFS-------------------------------------------------
------------------------------------------------------------
-----------------------DL-------------------------LT---F----
------------------------------------------------------------
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------------------------------------------

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------------------------------------------------------------
--------------------------------------MPPP-E----------------
-----------------KRR-RYE---E----------------GSLS----GSE-MQD-
-------------FGGP--RTTVE------------------------------------
-----------------------------------------------------------E
D-TS-----------------------SSSSTCSSSFPSSFPSS----------------
-----------------------------------------------------------S
S-STSSSYYPLM----SST--PEE--ISD---------------------LVG-------
----------I--------------------------------------SSPS---QSPQ
A----AGL---PIPLIT-S--TPVSQSDE----------------G-SSS-RQQESP---
------------N------PLQTLA------------AIEPLPRREIDEKVADLV-----
-------EFLLTKYRIKELFT-EAEML--AAVFKNEK-----QHFPLIFSEASEC-----
----MQIVFGIE---------VKE-IDPTE---------HSFI-----------------
-------L----------------------------------ITNLGL-TYD----GMLD
---DV-ESMPKTGIL-------ILILSIIFLEGNC------ASEE---IIWETLNVL---
-----GVY-SGM----EHFIYGEPQKLLTHDWVHE------KYLVYRQV-PQSDPVRYEF
----LWGPRAHAETS--KMTLLKFLAKVNGSDPK----S-FPVWYEE---ALREERERAK
ARISPTDDTD--------------------------------------------------
------------------------------------------------------------
-----------------------MA--------S----------------ASP----GA-
------------------------------------------------------------
---------TCS---------------------SFYS-----------------------
------------------N-----------------------------------------
------------------------------------------------------------
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--------------------------------------------------------MAE-
----------------------------------------------------------GS
FS-----V-Q-------SESYSVEDMDEGSDEVG--EEEMVEGNDYE----EFGAFGGYG
TLTSFDIHI--LRAFGSLG-----------------------------PGLRILSNEPWE
LENP-VLAQTLV-------EALQ--LDPETLANETAARAA-------------NVARAAA
---S----------NRA-ARAA--------------------AAAARTAFSQV---VASH
R-------------------------------------------------VAT-------
------PQVSGEDTQPTTYAA--EAQ--------------------GPTPEPPLASPQTS
------QMLVTSKMAAPEAPAT-SAQSQTGS---------------PAQ-----------
-------------EAA----------------TEGPSSACAFSQAPCAREVD-ANRPSTA
FLGQ----------------------------NDVFD-------FTQPAGV---------
----SGMAFPRPKRPAPAQEA--ATEGPSA---------AS-GVPQTGPGREVAATRPKT
T-----------------------------K-----------------------------
------------------------------------------------------------
--------------------------------------------------------SGKA
LAKTRWVEPQNVVAAA--------AAKA-KMATS---------IPEPEGAAA--ATAQHS
AE-----------------------P---------------------------------W
ARMGGKRTKKSKHLDDEY--------ESSE-EERETPAVPPTWRASQPSLT---------
---------V----R---------------------------------------------
----------------------------------------AQLA----------------
-----------------PRPP-----------------------------M----A----
-PRSQIPSRHVLCLP-PRNVTLL---QERANKLVK------YLMIKD-YKKIPI--KR--
------------------------------------------------------------
----ADM---LKDVIREYDEHFPEIIERATYTLEKKFGIHLKEIDKEEHLYI-LVCTRDS
SAR-LL-GKTKDT-PRLS---LLL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPFLGDLRKLITDDFVKQKNPELREE
TPLSMAPSWYLEYKKIPNSNP---P--EYEFLWGLRARHETSKMRVLRFIAQNQNR---D
------PREWKAHFLEAVDDAFKTMDVDMA--EEHAR----AQMRAQMNIGDEAL-----
------IGR--WSWDDIQVELLT-WDEDGDFGDAWA-RIPF----AFWARYHQYILNSNR
ANRRA------TWRAGVSSGTNGGASTSVLDGPSTS-ST---IRTRNAARAG--------
----ASFFSWIQHR----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------

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-------------ANAAVS----CTNSDEGT---------------NS-Q-KKESS----
-----------------------------KS-S---KGIEDLRRDPLHMKVALLV-----
-------HYLLHKYQKKEPIT-KSDML--KFVIKKYK-----YRFNEILKRASEH-----
----MELAFGLD---------LKE-VDPTR---------HCYA-----------------
-------L----------------------------------VSKLDL-TSN----GTMN
----EEENPPKTGLL-------MIVLGVIFINGNC------ATEE---EIWEVLNMM---
-----GVH-AER----KHFIYGDPKKVITEDLVQL------KYLEYRQV-ANSDPPRYEF
----LWGPRAHVETS--KMKVLEFLAKIYDTVPS----A-FPFWYEE---ALRDEEERAQ
ARMA-ARARAA-AMASARSRATASNFSQAK------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
---------------------------------------MAQKPDGGAGLRGFQA-----
--------------------------------------------------------EASV
EDSA-LLVQTLM-------EAIQ--IS-EAPPSSQA--TA--------------------
------------------------------------------AASGPNASPQSSQPPTA-
N------------------------------------------------EKAG-------
------TEVSAAAARPKT------------------------------------------
-----------------------------GF---------------KAQ-----------
-------------NAT----------------TKGPN---DYSQARNAKEMP-KNQSKAA
F-------------------KSQNGTP--KGPHAASD-------FSQAAPT---------
----SKS-AKKSEMAFKGQNST-TKAGPGT---------T-YNFPQSPSANEMTNNQPKT
------------------------------------------------------------
----------------------------------------------A-KAWNDTTKVPGA
-------------------------------DAQT-----------QNV-----------
----NQA---KMADVG--------T------SVG---------ISEADGAAAQTSADGSQ
TQNVE--------------------S---------------------------------R
TIIRGKRTRKVNNLNV---------EENNSGDQRRASLASGNWRSAPVPVTTQQNPPGAP
PNVVWQTPLA----WQNPS----GWQNQTARQTP----PAARQSPPARQTPAAWQNPVAW
QNPVIWPNPVIWQNPVIWPNPI-VWPGPIVWPNPMAWQSTPGWQSPPSWQAPPSWQSPQD
WQG---PPDWQVPPDW-SMPP-DWSFP-SDWPFPPDWIPADWPIPPDWQNLRPSPNLRS-
-SSNSRASQNQGPPQ-PRDVALL---QERANKLVK------YLMLKD-YTKVPI--KR--
------------------------------------------------------------
----SEM---LRDIIREYTDVYPEIIERACFVLEKKFGIQLKEIDKEEHLYI-LISTPE-
SLAGIL-GTTKDT-PKLG---LLL----------VILGI----------IF--------M
-NGNR----A-T--EAVLWEALRKMGLR--PGVRHPLLGDLRKLLTYEFVKQK-------
---------YLDYRRVPNSNP---P--EYEFLWGLRSYHETSKMKVLRFIAEVQKR---D
------PRDWTAQFMEAADEALDALDAAAA--EAEAR----AEARNRMGIGDEAV-----
------SGP--WSWDDIEFELLT-WDEEGDFGDPWS-RIPF----TFWARYHQNARSRFP
QAFTG---------------------P--IIGPSGTATA------NFAANFGAIGF----
--------FWVE------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------

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--------------------------------------MPRGQK---SKLRAREKR-RQA
-HG-----ETPGL-----------------------------------------------
-QA-------------AQAPAAEE------------------------------------
-----------------------------------------------------------E
-AST-------------------------PPSSP-----P---------------SGGTP
QSSP-A-------------------------AGR----------------PPSPTT---P
P--SSPPS----------------------------------------------------
------------------------------------------------------------
--------------GG-TP----HLRVDDGA---------------RC-P-EETHPG---
------------------------------P-SQAAGPMESYRRDPLTRKAN--------
--------------------I-KAAML--KIVNRKYK-----DQFPEILRRVCER-----
----MELVFGLE---------LKE-VDPSG---------QSYS-----------------
-------L----------------------------------VSKLDL-TTE----GSLG
----GGGDLPKTGLL-------MTLLAVIFMKGNR------ATEE---EVWEFLNAL---
-----GVF-AGR----KHLIFGEPHQLLTIDLVQE------KYLEYRQV-PRSDPPCYEF
----LWGSRAHAETT--KMK VLEILAKINDTVPS----S-FPVLYEE---ALRDEQERA-
AARI---PGRASVTTL---CCYLLSPNRAIMPR---------------------------
----------------------GRKSK-------------------------------LH
--------------------TREKRC-QTHGKAKG---SL--------------LLSSP-
---------------------PVGDIAQS-SPAAGLSSTPQEAQ-K-------------L
---------PIAT---T------------HSKGPS-CTSAGEA-------------ANS-
RDKEKSS SQAPFSTK-SSRRDPL---TRKVGLLKQ------FILHKF-KMREPI--MK--
------------------------------------------------------------
----KDM---MKIVNQKYKDQFPEILQRASESIEVVFGVDVKEVDSTSHTYD-LVSKMDL
PNNGRV-SGSRGL-PKTG---LLM----------TLLGM----------IF--------V
-KGNC----A-T--EKEIWKFLNMMHIY--AGRKHFFYGEPQKLITGDLVKLK-------
---------YLEYRRVPHSDP---P--LYEFLWGPRAKQETSKMKVLEFLAKVNNT---V
------PGAFSSQYEEAMREEEERAQARMA-ARAGTHACPNEA------PGPCPAAPLTP
GEV---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------

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------------------------------------------------------------
-------------------I----------------A-----------------------
------------------------HCCQ---MPPIRIKLSKRF-----------------
-----------------KNS-RRAQ-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------Y
QSRRAS---------------------------------------TQSQDLEIAQLSRAL
EETHLF-LCPQM----PGN--LKA------------------------------------
---------AP--------------------------------------GGDN---PSSP
QGPQSFSA---SSIGIT-A--SASSKSSE----------------VSMNQ-EAVP-----
------------G------TSEAVP------------DFMNVPVHSVDSKVAVLV-----
-------NFLLLKYRMKEPVT-KVDML--QVIN-DCE-----VHFPEILLRASER-----
----IEMLFGLD---------LKE-VDPTN---------HCYG-----------------
-------I----------------------------------FIKSGL-TYD----GM--
MH-GE-AGVPKTGIL-------ILILGVIFMKGNH------ATEE---EIWEVLNVT---
-----GLY-SGK----KHFIFGEPKQLITEDFVRE------GYLEFRQV-ASADPAQSEF
----LWGPKAHAETT--KMKVLEFIAKVHGTDPS----S-FPSQYEE---ALQDEKEKAQ
ARI---------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
---------------------------------------MAQNMDCGAGLLGFQACRAAC
RPLPQPPASTLPLSCIPQPARPPTYSPQLLDPPCPSCFCTNPPLLRCSLPSPAPALEASV
EDSA-LLMQTLM-------EAIQ--IS-EAPPTNQK--AA--------------------
------------------------------------------A-----SGPQSSQPPTA-
N------------------------------------------------EMAD-------
------IQVSAAAARPKT------------------------------------------
-----------------------------AF---------------KTQ-----------
-------------NAT----------------TKGPNGVYDFSQAHNAKEMP-NTQPKAA
F-------------------KPQNATP--KGPNAAYD-------FSQAATT---------
----GELAANKSEMAFKAQNAT-AKVGPNA---------T-YNFSQSLNANEMANNRPKT
------------------------------------------------------------
----------------------------------------------AFKAWNDTTKAPIT
-------------------------------DTQT-----------QNV-----------
----NQV---RTAASQ--------TDIETD--LG---------ISEPDGAAAQTSADGSQ
AQNLE--------------------S---------------------------------R
TIIRGKRTRKINNLNV---------EESSSGDQRRAPLAAGTWRSAAVPVTT-QNPPSAP
PNVLWQTPLA----WQNPS----GWQNQTARQTP----P-ARQSPPARQTPPTWQNPVAW
QNPVIWPNPVIWQNPVIWPNPI-VWPGPVVWPNPLAWQNPPGWQTPPGWQTPPGWQGPPD
WQG---PPDWPLPPDW-PLPP-DWPLP-TDWPLPPDWIPADWPIPPDWHNLRPSPNLRP-
-SPNSRASQNPGAAQ-PRDVALL---QERANKLVK------YLMLKD-YTKVPI--KR--
------------------------------------------------------------
----SEM---LRDIIREYTDVYPEIIERACFVLEKKFGIQLKEIDKEEHLYI-LISTPE-
SLAGIL-GTTKDT-PKLG---LLL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPLLGDLRKLLTYEFVKQK-------
---------YLDYRRVPNSNP---P--EYEFLWGLRSYHETSKMKVLRFIAEVQKR---D
------PRDWTAQFMEAADEALDALDAAAA--EAEAR----AEARTRMGIGDEAV-----
------SGP--WSWDDIEFELLT-WDEEGDFGDPWS-RIPF----TFWARYHQNARSRFP
QTLAG---------------------P--IIGPGGTASA------NFAANFGAIGF----
--------FWVE------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------

------------------------------------------------------------
------------------MSL--VSQNSRRRRGGRAN---AR------------------
--------------------KNNGKGHPAAVPGPDVPRDRNDPKIHQ-GLRAS-------
---EG-----------------PGT------------SMLPT------------------
---------------PREGPRA---------SVPPTAS---EGSSAPGQFII-SEG-PNT
SELPTS---------------R-KG----RGASRPPAVS---------------------
-----AGLNTAVSITASEGPS------SPVPPTAPKSSKA---YE-------HFTVSEGL
AI----------------------SE-QRHYDGGP--NMEPTL--------GEGPGISVP
PTFSEESGIS-------------------VPLPSDEGLGIF-------MS--PTISEGPG
INVPYPASEDPS--------TS---VP-----PTASNG------------LG---INLPP
T------FGEGLSISMLFSALEEPDIFAPPPSA---------------EGLFTS------
------------------------------------------------------------
------------------------------------------MSPPSGDIQSSWVPPIIL
EGCSVNV---------PPTSRNGLRTSVP---------------SAACESPST-------
------------------------------------S---------------AEGLSTSL
----------SSI----------------------------------------------S
AEGFCSS---------LAP-----------------------------------------
------------------------------------------------------------
---C------------------------AAEG--SCELLP---------------CGEGQ
STSG---LHSL------GEGSS-TSQMPLAAEGPSA--S---G---M---PT--------
---------------------------EADNP----------------------------
------EEALSCCA------SER--RNKSTSRALQK------------------------
-----------------------AKDPSVRP---------------K-------------
-------REDRFLDFQVLRDSKNSNSITIMGLGTSRVALTLKPQDPMEQNVAELL-----
-------QFLLLKDQTKYPIK-ESDMR--EFIDKDYR-----HQFPEILRRAAVH-----
----LECIFRFE---------LKE-LDTEE---------HIYI-----------------
-------L----------------------------------LNKLGPVPFE-----GLE
----DVPNGPKMGLL-------MMILGHILLNGNQ------AREA---DIWEMLWRF---
-----GVQ-RER----RLSVFGNVKRLLSVEFVWQ------RYLDYRPL-TDCVPVEYEF
----YWGPRSRAETT--KMKILKFMAKIYNKDPM----D-WPALYNE---ALEEDADRVV
VNN---------------------------------------------------------
------------------------------------------------------------
----FRVARPFRRPLFAE----------VSPE------------------LDA-S-----
------------------------------------------------------------
--------------------------------------G---------------------
---------SKYSPH-SWPESRL---ESKSRKLVQ------LFLLMD-STKLPI--PK--
------------------------------------------------------------
----KGI---LYYIGRECTKVFPDLLNRAARTLNHVYGTELVVLDPRNHSYT-LYNRREM
EDTEEI-MDSPNR-PGNN---FLM----------QVLSF----------IF--------I
-MGNH----A-R--ESAVWAFLRGLGVQ--NGRKHVI--------TCRYLSQR-------
---------YLDSLRVPDSDP---V--QYDFVWGPRARLETSKMKALRYVARIHRK---E
------PEDWPEQYREAMEDEANRAEAGRR-PL----------IVRNLR-----------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------

------------------------------------------------------------
------------------MSL--VSQNSRRRRRRVAK---ATA-----------------
----------H-NSSWDEMQAPNAPGFPADMPGSDVPRGPSDSQILQ-GLCAS-------
---ED-----------------PST------------SVLPT------------------
---------------SAEGPST---------FVPPTIS---EASSASGQPTV-SEG-PGT
SLLATP---------------S-EG----LSTSGPPTIS---------------------
-----KGLCTSVTLAVSEGRN------TSRPPTSSEEPST---S----------------
--------------------------VPATPGEGTSTSVPPTA--------SEGPSTSVV
PTPDEGPSTS-------------------VQSTAGEGPSTS-------VP--LTATEGLS
TSVPDTPDEGLS--------TS---VP-----PTATEG------------LST---PVPP
T------PDEGPSTSMPATPGEGRSTSMLPAAS---------------DGQSIS------
------------------------------------------------------------
------------------------------------------LVPTPGKGSSTSGPPTAT
EGLSTSV---------QPTAGEGPSTSVP---------------PTPCGGLS--------
---------------------------------------------------------TSV
----------PPT----------------------------------------------P
GEGLSTS---------VPPTAT--------------------------------------
-----------------------------------------------------------E
GLST--------------------------SVPP-----T---------------PGEGP
ST-SVLP-TPG------E-GRS-TSVPPT-ASD-GS--D---T-SVP---PT-PGE----
G--PSTLVQP----------------TASDRP--------------GSSVLPNP------
---GEGPSTLFSSSA-----SVDRNPSKCS-IVLPSPRVTKA------------------
----------------S------VDSDSEGP---------------K-------------
-------GAEGPLEFEVLRDCESPNSITIMGLSTSRVAITLKPQDPMEQNVAELL-----
-------QFLLVKDQSKYPIR-ESEMR--EYIVKEYR-----NQFPEILRRAAAH-----
----LECIFRFE---------LRE-LDPEA---------HTYI-----------------
-------L----------------------------------LNKLGPVPFE-----GLE
----ESPNGPKMGLL-------MMILGQIFLNGNQ------AKEA---EIWEMLWRM---
-----GVQ-RER----RLSIFGNPKRLLSVEFVWQ------RYLDYRPV-TDCKPVEYEF
----FWGPRSHLETT--KMKILKFMAKIYNKDPM----D-WPEQYNE---ALEEDAARAF
AEG---------------------------------------------------------
------------------------------------------------------------
----WQALPHFRRPFFEE----------AAAE------------------VAS-PD----
-SE---------------------------------------------------------
---------VSSY-------------------------S---------------------
---------SKYAPH-SWPESRL---ESKARKLVQ------LFLLMD-STKLPI--PK--
------------------------------------------------------------
----KGI---LYYIGRECSKVFPDLLNRAARTLNHVYGTELVVLDPRNHSYT-LYNRREM
EETEEI-VDSPNR-PGNN---FLM----------QVLSF----------IF--------I
-MGNH----A-R--ESAVWAFLRGLGVQ--SGRKHVI--------TCRYLSQR-------
---------YIDSLRVPDSDP---V--QYEFVWGPRARLETSKMKALRYVARIHRK---E
------PQDWPQQYREAMEDEANRADVGHR-QF----------FVHNFR-----------
------------------------------------------------------------
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--------------------------------------MPHGQ-----------------
-----------------ESQ-RCKSE-G----------------GLQA----PGE-AAW-
-------------LSKVGE-----------------------------------------
------------------------------------------------------------
--------------------------------------EEA-------------------
TAAGSC---------------------------------------P----------SSD-
----------LI----PGT--PQG------------------------------------
---------EP--------------------------------------GAAV---PRPP
KSPQPA---S-STTSSS-S--SGCSQSDD----------------SPSSQ-EEEG-P---
------------A------PWQCLE------------DAEFLLQDALDEKMAKLV-----
-------KLLLLKYLRKELIS-VEEML--SCVTIYYE-----DYFPGIFCKAFEC-----
----IHLIFGIE---------MKQ-ADLTG---------HLYG-----------------
-------L----------------------------------VPALGL-TCH----DV--
LG-GD-QTMPKTGLL-------ISILGLVFIGGRC------VPEL---QIWEALSVM---
-----GLY-AGS----EHCIFGEPRKLITEEWVQA------GYLEYRQV-PQSDPARFEF
----LWGPRAHAETS--EMRVLQYLARFNRNDPR----F-HPSVNQG---AVGDEKE---
------------------------------------------------------------
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--------------------------------------MSRY------------------
----------------GKHP-RLSLE-E-------------EGVNFQD----PPE-TD--
--------------ELPLVPTAEKEEREGEEEIKEE---DNN-----KLKNEED------
---NNEKQEDDES----KGE---------------------------KDGEEQGCDEVDE
EKNET----------GE-EEDIA-SIFFSSNVSLPSFTPP-------------------S
---PSS---------------------------------------S-------S------
---SSSSFFSLL----QSN--LGGSE----------------------------------
---------GY--------------------------------------SPGM---LSIF
QNAQSFFP---SS--------AIGGNLDE----------------GTSYQ-DES--V---
------------G------AIQSPE------------NPEALLNIVIQEKATDLV-----
-------FLFIYKYRMKEPIT-LSEIY--EVVTKDYE-----NHFPVIFMEASKC-----
----LEMTFGID---------IKE-SELLS---------SAYV-----------------
-------F----------------------------------VNSLNL-TYE----DMLS
---DN-DRLPRNAFL-------IVILGVIFIEGNC------ASEE---RIWEFLKLV---
-----GVH-DGE----EHFICGDPREFLTIDLVQQ------NYLEYRQG-ADSQPPCFEF
----LWGPRAYAETT--KMKVLEFLAKMNGCDPT----D-FSVWYEE---ALREEEERAW
AMNDSANGSPT-------------------------------------------------
------------------------------------------------------------
-----------------------SW------LVE----------------R---------
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-----------------------------------------------------MSEQSKD
LSD---------------------------------------------------------
------------------------------------------------------------
--------PNF----------------------------A---------------GEA-P
SPGA--------------------------HTS-----------------PGEPVG---V
P--LPASPAA-P---------LAQPPSPPAGP------------S---------------
----A----S--------------------------------------------------
------PSP--------------RDEMEEVD---------PKIL-RQA-A-EE--GL---
----------------------VYHPL----SAPQPG-PAPPAPAQLVQKAHELM-----
-------WYVLVKDQNKVVIW-FPDMV--KDVIGSYK-----KWCRSILRRTSLI-----
----LARVFGLH---------LRL-ISLHT---------MEFA-----------------
-------L----------------------------------VKALSPEELD-----RVA
----LNNRMPMTGLL-------LMILSLIYVKGRG------ARES---AVWNVLRIL---
-----GLR-PWK----KHSTFGDVRKLITEEFVQQ------KYLKYQRI-PYTEPPEYEF
----FWGSRASQEIT--KMQIMQFLARVFKKDPQ----A-WPSRYRE---ALEEARALQE
ANAPV----------------------------------HCPRSSVSED-----------
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--------------------------------------MPHS-L----------------
-----------------KSE-CNKLE-L----------------SLQA----QNE-APD-
-------------L-----MDAEE------------------------------------
-----------------------------------------------------------E
A-TT--------------------------------------------------------
------------------------------------------------------------
--TTSSSLSPLV----QGT--PEAM---P---------------------AAG-------
----------T--------------------------------------PSVP-------
QSSQRACS---SPTAII-A--TPSSQSDE----------------S-SRN-QEEEGP---
------------STPQ---------------------------PPVLHKKVAELV-----
-------QFLTEKYMTKEPIT-KAEML--KSILKEHR-----DHFPVVFKKVCEC-----
----MEVVFGIE---------VKE-MDPTS---------HSYV-----------------
-------L----------------------------------VKTLDL-TYD----GMLS
---D-DQGMPKTGLL-------ILILGIIFMEGNR------APEE---KIWEVLNMM---
-----GVF-AGK----KDFIYGEPRKLITKDLVQE------RYLEYRQV-PNSDPACYEF
----LWGPRAHAETT--KMKVLKFFTKAIGTDPT----S-FPIWYEE---ALRDEKERAD
TRVATSNG-TT-------------------------------------------------
------------------------------------------------------------
-----------------------DT-------------------------ASS----SV-
------------------------------------------------------------
---------MSS---------------------E--------------------------
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-----------------MENESIMQTQ--SL-SQAQRNLQNHSQEQINLKVGEVV-----
-------QYLLIKDQKKLPIK-RADIV--RNVVKEYK-----DIYPEIFRRAQIA-----
----LQQVFGFQ---------LEE-IDTKS---------HIYI-----------------
-------L----------------------------------TNKLQRVQGD-----GMR
----VDENTSKLGLL-------MVILSLIFMKGNT------AKES---AVWEMLRRL---
-----RIE-PAE----KHSDFGDVKKLITEEFVKQ------KYLEYSKV-LHTDPVEYEF
----RWGQRAFKETS--KMQVLEFVSKIQQKDPK----S-WTTQYKD---AQEQTQVAAR
------------------------------------------------------------
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--------------------SNHHLLPSSLPATLNSITMPHS-Q----------------
-----------------KNQ-SHKLE-V----------------GLQA----EKE-AQG-
-------------LMGSQVPVAEE------------------------------------
-----------------------------------------------------------K
K-AT-----------------------A--------------------------------
------------------------------------------------------------
-----SLLSSLI----QGT--PEVV---P---------------------TAG-------
----------T--------------------------------------QSVP-------
QSSQGACS---SFTTIE-A--IPLSKSNE----------------G-SSQ-EE-------
-------------------SPSSFQ------------APTFLLGDVLNKKLAQLV-----
-------QLMRVKYVTKEPIT-KAEIL--ENV----------------------T-----
----MEIVFGIE---------AKE-VDPTS---------HSYV-----------------
-------L----------------------------------QKTLGL-TYD----GMLN
---DG-QSMPKTGFL-------IYILGVIFMEGNR------VTEE---RIWKVLNMI---
-----GVC-AGQ----KDFIYGEPRKLITKDLVEE------RYLEYQQV-PNSDPPCYEF
----RWGPRAHAETS--KMKILKFFSKVNGVDPT----S-FPSWYEE---ALRDEKEKA-
------------------------------------------------------------
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--------------------------------------MSLEQ-----------------
-----------------RSP-HCKPD-E----------------DLEA----QGE-DLG-
-------------LMGAQEPTGEE------------------------------------
-----------------------------------------------------------E
E-T---------------------------------------------------------
------------------------------------------------------------
---TSSSDSK-----------EEE------------------------------------
---------VS--------------------------------------AAGS---SSPP
QSPQGGAS---SSISVY-Y--TLWSQFDE----------------GSSS--QEEEEP---
------------S------SSVDPA------------QLEFMFQEALKLKVAELV-----
-------HFLLHKYRVKEPVT-KAEML--ESVIKNYK-----RYFPVIFGKASEF-----
----MQVIFGTD---------VKE-VDPAG---------HSYI-----------------
-------L----------------------------------VTALGL-SCD----SMLG
---DG-HSMPKAALL-------IIVLGVILTKDNC------APEE---VIWEALSVM---
-----GVY-VGK----EHMFYGEPRKLLTQDWVQE------NYLEYRQV-PGSDPAHYEF
----LWGSKAHAETS--YEKVINYLVMLNAREPI----C-YPSLYEE---VLGEEQEGV-
------------------------------------------------------------
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--------------------------------------MPRGQK---SKLRAREKR-RQA
-RA-----KNAPK-----------------------------------------------
--E-------------GEASSGPF------------------------------------
-----------------------------------------------------------S
-EFP-------------------------D------------------------------
QADP-D-------------------------TGM----------------PTPPNM---P
Q--GA-------------------------------------------------------
------------------------------------------------------------
--------------HYNFT----HTYESTGP---------------EN-Q-DE-------
-----------------------------KN-SDDSDELEAWSKDPINRKVVLLV-----
-------QFLMEKYHKKEVIT-KADMQ--KCVVKTSK-----GHFNEILKRASEH-----
----MELAFGVD---------LKE-VDPVR---------HSYA-----------------
-------L----------------------------------FNKLDH-TFD----VMRG
----E-EIMPNTGLL-------MMVLGVIFKKNNC------ASEK---DVWEVLNMM---
-----GVY-ANR----KHFIYGDPTKVITEDLVNL------KYLEYRKV-PDSNPPSFEF
----TWGSRAQAEIS--KMKVLEFWAKIHDTTPD----A-FVPLYEI---ALKDEEERAQ
ARSA-ARA----------------------------------------------------
-----------------------------------------------------------R
--------------------TAATA------------------------------SS---
------------------------------------------------------------
------------H-----------------------------------------------
------------------SKAMV---SSFS--HAK-------------------------
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---------------------------------------MAQKPDGGAGLRGFQA-----
--------------------------------------------------------EASV
EDSA-LLVQTLM-------EAIQ--IS-EAPPTRQA--TA--------------------
------------------------------------------AASGQNASPRSSQPPTA-
N------------------------------------------------EVAN-------
------TEVSTAAARPKT------------------------------------------
-----------------------------GF---------------KAQ-----------
-------------NTT----------------TKGPN---DFSQARNAKEMP-KNQSKMA
F-------------------KSQNGTS--KGPNAASE-------FYQAANA---------
----GKSAAKKSEMAYRAHNAT-TKPGPSG---------A-YNFSQCPSANEMINKQPKT
------------------------------------------------------------
----------------------------------------------AAKAWNGTTKVPAA
-------------------------------DAQI-----------QNV-----------
----NQV---KMADVG--------T------SPG---------ISETDGAAAQTLADGSQ
AQNVE--------------------S---------------------------------R
TIIRGKRTRKINNLNV---------EENGSGDQRRASLASGNWRSAPVPVTT-QNPPGAP
PNVLWQTPLA----WQNPS----GWQNQTARQTP----P-ARQSPPARQTPSAWQNPVAW
QNPVIWPNPVIWQNPVIWPNPI-VWPGPIVWPNPMAWQNAPGWQTPPSWQAPPSWQGPQD
WQG---PPDWQLPPDW-SLPP-DWSFP-TDWPFPPDWIPTDWPIPPDWQNLRPSPNLRS-
-SPNSRASQNQGAPQ-PRDVALL---QERANKLVK------YLMLKD-YTKVPI--KR--
------------------------------------------------------------
----SEM---LRDIIREYTDVYPEIIERACFVLEKKFGIQLKEIDKEEHLYI-LISTPE-
SLAGIL-GTTKDT-PKLG---LLL----------VILGI----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPLLGDLRKLLTYEFVKQK-------
---------YLDYRRVPNSNP---P--EYEFLWGLRSYHETSKMKVLRFIAEVQKR---D
------PRDWTAQFMEAADEALDALDAAAA--EAEAR----AEARTRMGIGDEAV-----
------SGP--WSWDDIEFELLT-WDEEGDFGDPWS-RIPF----TFWARYHQNARSRFP
QAFTG---------------------P--IIGPSGTATA------NFAANFGAIGF----
--------FWVE------------------------------------------------
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----------------------LGQVSTMFSEDDFQST---EGAPSGPQM----------
---------QWSQDLPRVQVFRE----------QANQE---DRSPR-RTQRITGG-EV--
-----------------LWGPITQIFPTVWPADLTGVIMPLEQ-----------------
-----------------RSQ-HCKPE-E----------------AFSP-----RR-QPG-
-------------LGGGAQALQAE------------------------------------
-----------------------------------------------------------E
Q-E---------------------------------------------------------
------------------------------------------------------------
---AASFSSTLN----VGT--LEE------------------------------------
---------VP--------------------------------------ATES---PSPP
QSPQGESS---SPTAMD-S--IFGSLSDE----------------GSSS--QEEEGP---
------------S------TSPDLI------------DPESFSQDILHDKIIDLV-----
-------HLLLCKYRVKGLIT-KAEML--GSVIKNYE-----DYFPEIFREASEC-----
----MQLLFGID---------VKE-VDPTS---------HSYV-----------------
-------L----------------------------------VTSLSL-SYD----GIQG
---DE-QSMPKSGLL-------II--------GNC------VPEE---VMWEVLSIM---
-----GVY-AGR----EHFLFGEPKKLLTHDWVQE------KYLVYRQV-PGTDPACYEF
----LWGPRAHAETS--KMKVLEYIANANGRDPS----S-YSSLYED---ALREEEEGV-
------------------------------------------------------------
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----------------------------------------------------ELM-----
-------WYVLVKDQKRMIIW-FPDMV--KDVIGSYK-----KWCRSILRRTSLI-----
----LARVFGLH---------VRL-TSLHT---------MEFS-----------------
-------L----------------------------------VKALEPEELD-----RVA
----LSNSMPMTGLL-------LMILSLIYVKGRG------ARES---AVWNVLRIL---
-----GLR-PWK----KHSTFGDVRKLITEEFVQQ------NYLKYQRV-PHVEPPEYEF
----FWGSRASREIT--KMQIMEFLARVFKKDPQ----A-WPSRYRE---ALEEARALRE
ANPTA----------------------------------HCPRNSVSED-----------
------------------------------------------------------------
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--------------------------------------------------------MAE-
----------------------------------------------------------GS
FS-----V-Q-------SENYSVEDMDEGSDEVR--EEEMVEGNDYE----EFGAFGGYG
TLTSFDIHI--LRAFGSLG-----------------------------PGLRILSNEPWE
LENP-VLAQTLV-------EALQ--LDPDTLANETAARAA-------------NVARAAA
---S----------NRA-ARAA--------------------AAAARTAFTQV---VASH
R-------------------------------------------------VAT-------
------PQVSGEDTQPTTYAA--EAQ--------------------GPTPEPPLASPQTS
------QMLVTSEMAAPGAPVT-STQSQTGS---------------PAQ-----------
-------------EAA----------------TEGPSRACAFSQAPCAREVD-TTRPSTA
FLGQ----------------------------NDVFD-------FTQPAGV---------
----SGMAFPRPKRPAPAQEA--ATEGPSA---------AS-GVPQTGPGREVAATRPKT
T-----------------------------K-----------------------------
------------------------------------------------------------
--------------------------------------------------------SGKA
LAKTRWVEPQNVVAAA--------AAKA-KMATS---------IPEPEGAAA--ATAQHS
AE-----------------------P---------------------------------W
ARMGGKRTKKSKHLDDEY--------ESSE-EEREPPAVPPTWRASQPSLT---------
---------V----R---------------------------------------------
----------------------------------------AQLA----------------
-----------------PRRP-----------------------------V----A----
-PRSQIPSRHVLCLP-PRNVTLL---QERANKLVK------YLMIKD-YKKIPI--KR--
------------------------------------------------------------
----ADM---LKDVIREYDEHFPEIIERATYTLEKKFGIHLKEIDKEEHLYI-LVCTRDS
SAR-LL-GKTKDT-PRLS---LLL----------VILGI----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPFLGDLRKLITDDFVKQKNLELREG
TPLSMAPSWYLEYKKIPNSNP---P--EYEFLWGLRARHETSKMRVLRFIAQNQNR---D
------PREWKAHFLEAVDDAFKTMDVDMA--EEHAR----AQMRAQMNIGDEAL-----
------IGR--WSWDDIQVELLT-WDEDGDFGDAWA-RIPF----AFWARYHQYILNSNR
ANRRA------TWRAGVSSGTNGGASTSVLDGPSTS-ST---IRTRNAARAG--------
----ASFFSWIQHR----------------------------------------------
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--------------------------------------MDPPN-----------------
-----------------NSRN-VN-Q-D----------------STHS----ERE-TRD-
-------------LEAGEEE----------------------------------------
------------------------------------------------------------
--------------------------------------S---------------------
------------------------------------------------------------
----------TT----SG------------------------------------------
---------------------------------------------------DV---LGSS
QGAQRA--------SFP-S--TAGV------------------------P-SVEASG---
------------S------QI-E-F------------YPDILRQQILNSKTIDLI-----
-------LFLILKYRRKQQTC-KAEIL--YMVIRGYE-----DHFPAIFTKASEC-----
----LRLTFGLE---------IIE-RNPRV---------HSYS-----------------
-------L----------------------------------VNALGL-TYD----GM--
LH-GF-RGVPKIGLL-------IIVLCIIFIQDNC------ASEQ---ELWRILNNM---
-----GLY-AGR----DHFIYGDPGVLITEHFVQE------GYLECRQV-PGSDPPTREY
----LWGPRAHAETT--KMKVLKHFASIVKQDPR----S-YPTRYAD---ALKDEIDRT-
------------------------------------------------------------
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---------------------------------------------------MP-------
QSPQRACS---FSAAIA-A--APPSKPYE----------------G-PSS-Q--------
---------------EVPGTLRVLP------------GIEALSCDALDKKVADLV-----
-------QFLSIKYVTKEPIT-ETEML--KVVIRENN-----DHFPVIFKKACEC-----
----MEVVFGIS---------VEK-MDPMG---------HSYI-----------------
-------L----------------------------------VKTLDL-TYD----GMLS
---N-DQGMPKTGVL-------ILILGVIFMEGNH------ASEE---KIWEVLNMI---
-----GVY-SGS----KDFIYGEPGKLITRDLVQE------RYLEYRQV-PNSDPACYEF
----LWGPRAYAETS--KMKVLNFFAKVTGTYPS----S-FPSLYQE---ALRDEKERAQ
FGTLGNCSSF--------------------------------------------------
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---------------------------------------MSDT-----------------
---------------SE-SGT----------------------------GTTHFQAEASE
KDSG-LNMQTLL-------TVTK--NMEVSETLEAS------------------KA----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------PEVSETVKVS-------NAAGVS---------------KTT-----------
-------------EV---------------------------SKTPEAQEAT-ATQVSPT
-TKSTDTQVLAA----EK--KSPAGDT--KKQNADPQ-------AVTVPAT---------
----ETRK-----ISC--------------------------------------------
------------------------------------------------------------
--------------------------------------------------------VA--
-------------------------------DMKV-------------------------
----N-T--KALKTEA--------AASQAPEDES---------EP--EGTAA-AQESQDT
QPEVK--------------------A---------------------------------K
KAWKVKHLNGEEDGN---------------SDQSQASGTTGGRRVSKALMASVACRASRG
PIAFCAHRVS----RTWLA----A------------------------------------
------------------------------------WAWRALF----SLRSPKAYRGKAR
HR----------------------------------------------------------
-------GQEPEVPP-PYEVALL---QGKANDLVK------YLLVKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LKDIIKEYTDVYPEIIERAGYSLEKVFGIQLKEIDKNDHLYI-LLSTLEP
TDAGIL-GTTKDS-PKLG---LLM----------VLLSI----------IF--------M
-NGNR----S-S--EAVIWEVLRKLGLR--PGIHHSLFGDVKKLITDEFVKQK-------
---------YLDYARVPNSNP---P--EYEFFWGLRSYYETSKMKVLKFACKVQKK---D
------PKEWAAQYREAMEADMKAAAEAAA--EAKAR----AEIRARMGIGLGSE-----
----NAAGP--CNWD-------------EADIGPWA-KARIQAGAEAKAKAQESG--GAS
NGAN----------------------A--SGSFGASASLTPTFTFGLFTGLSGAGASSSG
SSGACG-FSYK-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------

------------------------------------------------------------
------------------MSL--VSQNSRRRRRRVAK---ATA-----------------
----------H-NSSWDEMQAPNAPGFPADMPGSDVPQGPSDSQILQ-GLCAS-------
---EG-----------------PST------------SVLPT------------------
---------------SAEGPST---------FVPPTIS---EASSASGQPTV-SEG-PGT
SLLATP---------------S-EG----LSTSGPPTIS---------------------
-----KGLCTSVTLAASEGRN------TSRPPTSSEEPST---S----------------
--------------------------VPATPGEGTSTSVPPTA--------SEGPSTSVV
PTPDEGPSTS-------------------VQSTAGEGPSTS-------VP--LTATEGLS
TSVPDTPDEGLS--------TS---VP-----PTATEG------------LST---PVPP
T------PDEGPSTSMPATPGEGRSTSMLPAAS---------------DGQSIS------
------------------------------------------------------------
------------------------------------------LVPTPGKGSSTSGPPTAT
EGLSTSV---------QPTAGEGLST----------------------------------
----------------------------------------------------------SV
----------PPT----------------------------------------------P
GEGLSTS---------VPPTAT--------------------------------------
-----------------------------------------------------------E
GLST--------------------------SVPP-----T---------------PGEGP
ST-SVLP-TPG------E-GRS-TSVPPT-ASD-GS--D---T-SVP---PT-PGE----
G--PSTLVQP----------------TASDRP--------------GSSVLPNP------
---GEGPSTLFSCSA-----SVDRNPSKCS-IVLPSPRVTKA------------------
----------------S------VDSDSEGP---------------K-------------
-------GAEGPIEFEVLRDCESPNSITIMGLSTSRVAITLKPQDPMEQNVAELL-----
-------QFLLVKDQSKYPIR-ESEMR--EYIVKEYR-----NQFPEILRRAAAH-----
----LECIFRFE---------LRE-LDPEA---------HTYI-----------------
-------L----------------------------------LNKLGPVPFE-----GLE
----ESPNGPKMGLL-------MMILGQIFLNGNQ------AKEA---EIWEMLWRM---
-----GVQ-RER----RLSIFGNPKRLLSVEFVWQ------RYLDYRPV-TDCKPVEYEF
----FWGPRSHLETT--KMKILKFMAKIYNKDPM----D-WPEQYNE---ALEEDAARAF
AEG---------------------------------------------------------
------------------------------------------------------------
----WQAIPHFRRPFFEE----------AAAE------------------VAS-PD----
-SE---------------------------------------------------------
---------VSSY-------------------------S---------------------
---------SKYAPH-SWPESRL---ESKARKLVQ------LFLLMD-STKLPI--PK--
------------------------------------------------------------
----KGI---LYYIGRECSKVFPDLLNRAARTLNHVYGTELVVLDPRNHSYT-LYNRREM
EETEEI-VDSPNR-PGNN---FLM----------QVLSF----------IF--------I
-MGNH----A-R--ESAVWAFLRGLGVQ--SGRKHVI--------TCRYLSQR-------
---------YIDSLRVPDSDP---V--QYEFVWGPRARLETSKMKALRYVARIHRK---E
------PQDWPQQYREAMEDEANRADVGHR-QF----------FVHNFR-----------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------

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------------------------------------------------------------
------------------------------------------------------------
--------------------------------------MPRKHK---NKQHAHGKR-HQV
-QG-----DTPEA-----------------------------------------------
-QA-------------SAAAAPGE------------------------------------
-----------------------------------------------------------E
-CP--------------------------SSPSS-----A---------------PQGSP
PSSP-A-------------------------AGD----------------GQELQG---A
M--APSSPVA-E------------------------------------------------
------------------------------------------------------------
-----------------AS----WAGSEEGA---------------QG-P-EE-ESA---
-----------------------------DA-ARAALLARSIRKDPLMRKASLVM-----
-------DFLLERYTKKEPIT-QNGML--NVIGRKYK-----QHLPEILSRASER-----
----VELVFGLE---------LKE-VDCSR---------NIYT-----------------
-------L----------------------------------VNKFSL-GVE---EGS-S
----DEEELPKSGLL-------MALLGIIFTKGNR------ASEE---EIWDFLNVL---
-----GIH-AGK----KHSIFGEPRKLITKDLVQK------GYLIYRRV-PNSDPPGYEF
----LWGPRAYAETT--KMKVLEVLAKIQDKVPS----S-FPDLYDE---ALRDQVERAA
LR-GA-------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------MSEQSKD
LSD---------------------------------------------------------
------------------------------------------------------------
--------RNF----------------------------A---------------AEA-P
SSEV--------------------------HSS-----------------PGVPEG---V
P--PS-----ET---------LAEPQSPPLGP------------T---------------
----AAPQAA--------------------------------------------------
------QPP--------------QVPSDEGD---------PKAL-QQA-A-EE--GR---
----------------------AHQAP----SAAQPG-PAPPAPAQLVQKAHELM-----
-------WYVLVKDQKKMIIW-FPDMV--KDVIGSYK-----KWCRSILRRTSLI-----
----LARVFGLH---------LRL-TSLHT---------MEFA-----------------
-------L----------------------------------VKALEPEELD-----RVA
----LSNRMPMTGLL-------LMILSLIYVKGRG------ARES---AVWNVLRIL---
-----GLR-PWK----KHSTFGDVRKLITEEFVQQ------NYLKYQRV-PYVEPPEYEF
----FWGSRASREIT--KLQIMEFLARVFKKDPQ----A-WPSRYRE---ALEEARALRE
ANPTA----------------------------------HCPRSSVSED-----------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
--------------------------------------------------MLQKPE---S
G--------------------------------------------------VLPVP----
-------QVE----------------------------GEMDGSHDGETQALT-----V-
-SQEE------------------APKEDLDA---------------VKEE-G--------
----------------AAEPALTPKGA--RA-LAAKTLARRRACRRLDRTVAELV-----
-------QFLLVKDKKKSPIT-RSEMV--KYVIGDLK-----DLFPEIIARAAEH-----
----LRYVFGFE---------LKQ-LDRKH---------HTYI-----------------
-------L----------------------------------MNKLKPPEDK--------
-EEDLGGDGPRLGLL-------MMILGLIYMKGNS------AREA---QVWEMLRRL---
-----GVR-PSK----YHFLFGYPKRLIMEDFVQL------RYLNYRRV-PHTNPPECEF
----SWGPRSNLETS--KMKVLGFVAKLHKKEPQ----H-WPVLYRE---ALADEADRAR
AEAS-I----RP----------RARARANARAG---------------------------
------------------------------------------------------------
-NH----R------W---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
---------------------------------------MSDT-----------------
---------------SE-SGT----------------------------GPTCFQAEASE
EDPG-LKMQTIL-------TVTQ--NLEASETPKAS------------------KT----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------PEVPKATKTS-------NAAGVS---------------KT------------
---------------------------------------------TAAQEVS-ATQASPT
-TKLTDTQFLAA----KK--KSLAADT--NMQHTDPQ-------AVTVSPT---------
----ETKK-----ASS--------------------------------------------
------------------------------------------------------------
--------------------------------------------------------VA--
-------------------------------DTKV-------------------------
----N-T--KTLETES--------TASQALADEP---------EP--EGAAGQAQENQDT
RPKIK--------------------A---------------------------------K
KARKVKHLNGEEDGS---------------SDQSQASGTTGGRRISKALMASMARRASRG
PIAFWARRAS----RTRLA----A------------------------------------
------------------------------------WARRALL----SLRSPKARRGKAR
RRA---------------------------------------------------------
-AKLQS-SQEPEAPP-PRDVALL---QGRANDLVK------YLLVKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LKDIIKEYTDVYPEIIERAGYSLEKVFGIQLKEIDKNDHLYI-LLSTLEP
TDAGIL-GTTKDS-PKLG---LLM----------VLLSI----------IF--------M
-NGNR----S-S--EAVIWEVLRKLGLR--PGIHHSLFGDVKKLITDEFVKQK-------
---------YLDYVRVPNSNP---P--EYEFFWGLRSYYETSKMKVLKFACKVQKK---D
------PKEWAAQYREAMEADMKAAAEAAA--EAKAR----AEIRAQMGIGLGSE-----
----NAAGP--CNWD-------------EADIGPWA-KARIQAGAEAKAKAQESG--GAS
AG------------------AS----T--GGNFGASTSLTATLTFGLFAGLGGAGASASG
SSGACG-FSYKYS-----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------MPR---------------------------
----------------------GQKSK---------------------------------
-QR-----------------SRVKRR-QARAHTQR---VEGAQAT---AAEEA-GAPSS-
-SS-------------------PTA-R-----------VPWEAL-R------------VP
------------------------------PIT-TVVYASGAG---------AFGGAWAR
DAGGPSTSEPPPSAG-GSQKDSL---GRQAGILLQ------FLLNRY-KMKAPV--TK--
------------------------------------------------------------
----AEM---LKRVCRKYQRHFPEILRRTTERMEMVFGLDLKEVDRSAQSFA-VVSNLDI
KDEERL-TAAGEI-PKNG---LLM----------PLLGV----------IF---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------IMPRGQR---SKQRSRGKR-RNI
-PV-----ENGSP-----------------------------------------------
-MD-------------NEATPIET------------------------------------
-----------------------------------------------------------E
-EDP-------------------------SAASS-----P---------------VENQA
ESVS-I-------------------------DDI----------------PSSSEM---P
------------------------------------------------------------
------------------------------------------------------------
---------------------------EAGA---------------QS-Q-ED-------
-----------------------------MT-PDLSRITDSWRRDPLNRMVVLLV-----
-------QFLIDKYQNKETIM-KSEML--KLVIKKHK-----PQFNEILKRASEH-----
----MELAFGVD---------LKE-VDPVR---------HCYT-----------------
-------L----------------------------------VNKLDH-SID----GPMS
----EEDNIPKTGLL-------MIVLGLIFMNENY------APEE---EVWEVLNLM---
-----GVY-ANR----RHFIYGNPKKVITQDLVEL------QYLKYQQV-PNSDPPRYEF
----TWGPRSLAEVS--KMKILEFLAKIHDSSPS----A-FPYWYEE---ALKDEEERAQ
ARIA-ARA----------------------------------------------------
-----------------------------------------------------------R
--------------------NTAVMP-----------------------------RA---
------------------------------------------------------------
------------D-----------------------------------------------
------------------SKASS---SSFS--QTK------I------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------M-------SLVSQNACH----------------------
------------------------------------------------------------
------------------CSAETT------------------------------------
-----------------------------------------------------------A
-DY---------------------------------------------------------
-----------------------------------------------------------S
D--FQGEMQA----------------TNASGS------------P-T-------------
---------------------------------------------------SM------L
----------VPDALQ----GPQAPVDPQGA---------------SAPQ-AA-------
---------QDP----N--DLEV--LID-EQSRRLGA---LRVYDPLEDKSIALV-----
-------NFMRMKSQIEGSIQ--QTEM--LEFLREYS-----DQFPEILRRASAH-----
----LDQVFGLN---------LRV-LDPQA---------DTYN-----------------
----------------------L-------------------ISKRGH-QTT----DRIA
----ESLDMPKAGLL-------ALVLCHILLNDNR------AREA---SIWDLLLKV---
-----DVL---DEPQRINIPFGNTRNLLTTDFVRM------RFLEYWPV-YGTNPLEFEF
----LWGSRAHK--EITKM-----------------------------------------
------------------------------------------------------------
--------------------------E-------------------------------AL
K-----------------------F---VA----------------QAHDEEP-------
------------------------WSWPE-EYN------------KALEADKAKER---S
---------------------------------------------------------QA-
AG---L--------E-FWSED---TMNDKANDLVQ------LAINVT-EELLPI--HQ--
------------------------------------------------------------
----DEL---LAHTGKEFEDVFPNILSRATLILDLFYGFSLIEVDTSEHIYL-LVQQPES
EEEQMM-LESLGR-PTQE---YVM----------PILGL----------IF--------L
-MGNR----V-K--EANVWNLLRRYGVD--VGRKHAI--------TCKLMRQR-------
---------YLECRPLSYSNP---V--EYELLWGPRAHLETTKMKALEYMARLYRK---R
------PQDWPEQYREAVE-----------DEEARARSEATAMFF----FGP--------
---M--------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------LTSAIMSHR-C----------------
-------------QRNK---------------------------RRTL----EEV-LQS-
-------------LVAAQGQRAQE------------------------------------
-----------------------------------------------------------E
A-AA-----------------------AATA-----------------------------
------------------------------------------------------------
--------SAVI----PGI--PEEM---P---------------------AAA-------
----------A--------------------------------------SSPP---QS--
--PQGASS---LPTGLA-S--PPGSQYDE----------------S-SSR--QEGEP---
------------S------TLQEPA------------NLEPLLRRTLEEKMSNLV-----
-------HFLLLKYRIKEPIT-KDEML--SIVIQEYG-----DHFPEIFKEASEC-----
----MQLVFGVD---------VKE-VDPAN---------HCYV-----------------
-------L----------------------------------VTALGL-SYD----EMLN
---DF-HSLPKVGLL-------IIIMGLIFLEGDC------AREE---VIWEALSMM---
-----GVH-DGW----EHFIYGEPRKLITHHWVQE------GYLVYQQV-PQSDPARYEF
----LWGPRAHAETT--KMKVLEYVARINGHDPR----S-FPRLYEE---ALRDEER---
------------------------------------------------------------
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------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------MHSQLNLERSKDK-----------------------------------------
------------------------------------------------------------
------------------G-------------------------------------I---
---------EEEIL----LG---------SALARG-TGAMAQKMDCGAGLLGFQ------
-------------------------------------------------------AEASV
EDST-LLMQTLM-------EAIQ--IS-EAPPTNQA--T---------------------
-------------------------------------------AAGLNASAQSSQPPTS-
S------------------------------------------------EMAD-------
------IQVLAAATRPKT------------------------------------------
-----------------------------AF---------------KAQ-----------
-------------NAT----------------TKGPNGAYDFSQALNAKEMP-NVPPKAA
F-------------------KSQNATL--KGPNAAYD-------FSQAATT---------
----SELTANKSEMAFKAQNAT-TKVGPNA---------T-YNFSQSLSATEMVNAQPKT
------------------------------------------------------------
----------------------------------------------AFKAWNDTTKAPTV
-------------------------------DTQT-----------QNI-----------
----NQA---KMATSQ--------TEVET--NPG---------IPESDGAAAQTSADGSP
AQNLE--------------------S---------------------------------R
TIIRGKRTRKINNLNV---------DENSNGDQRRAPLATGTWRSAPVPVTT-QNPPGAP
PNVLWQTPLA----WQNPS----GWQNQPARQTP----P-ARQSPPARQTPPAWQNPVAW
QNPVIWPNPVIWQNPVIWPNPI-VWPGPVVWPNPLAWQNPPGWQTPPGWQNPPGWQGPPD
WQG---PPDWPLPPDW-PLPP-DWPLP-TDWPLPPDWIPTDWPVPPDWQNLRPSPNLRP-
-SPNSRASQNLGASQ-PRDVALL---QERANKLVK------YLMLKD-YTKVPI--KR--
------------------------------------------------------------
----SEM---LRDIIREYTDVYPEIIERACFVLEKKFGIQLKEIDKEEHLYI-LISTPE-
SLAGIL-GTTKDT-PKLG---LLL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPLLGDLRKLLTYEFVKQK-------
---------YLDYRRVPNSNP---P--EYEFLWGLRSYHETSKMKVLRFIAEVQKR---D
------PRDWTAQFMEAADEALDALDAAAA--EAEAR----AEARTRMGIGDEAV-----
------SGP--WSWDDIEFELLT-WDEEGDFGDPWS-RIPF----TFWARYHQNARSRFP
QTFTG---------------------P--IIGPGGTAST------NFAANFGAIGF----
--------FWVE------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------MSEQSKD
LSD---------------------------------------------------------
------------------------------------------------------------
--------PNF----------------------------A---------------AEA-P
SSEV--------------------------HSS-----------------PGVPEG---V
P--PS-----ET---------LAEPQSPPLGP------------T---------------
----AAPQAA--------------------------------------------------
------QPP--------------QAPSDEDD---------PKAL-QQA-A-EE--GR---
----------------------AHQAP----SAAQPG-PAPPAPAQLVQKAHELM-----
-------WYVLVKDQKKMIIW-FPDMV--KDVIGSYK-----KWCRSILRRTSLI-----
----LARVFGLH---------LRL-TSLHT---------MEFA-----------------
-------L----------------------------------VKALEPEELD-----RVA
----LSNRMPMTGLL-------LMILSLIYVKGRG------ARES---AVWNVLRIL---
-----GLR-PWK----KHSTFGDVRKLITEEFVQQ------NYLKYQRV-PYVEPPEYEF
----FWGSRASREIT--KLQIMEFLARVFKKDPQ----A-WPSRYRE---ALEEARALRE
ANPAA----------------------------------HCPRSSVSED-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------PSPNLLHTLLLLPPTQVIMPLS-K----------------
-----------------KSQ-CPKPK-Q----------------SLQA----QTE-APS-
-------------LMASQVPLTEE------------------------------------
-----------------------------------------------------------G
A-----------------------------------------------------------
------------------------------------------------------------
---ASPSLSPLI----QGS--TEVV---L---------------------AAG-------
----------T--------------------------------------PSVP-------
QNSQRACP---SSTAIK-A--TPSSKSNE----------------A-SSS-QD-EV----
-----------------PTTLQAPP------------NPESLFTEVLQNKVSELV-----
-------HFLSIKYITKEPIT-KAEML--ESVIREHK-----DHFPVVFKKACEC-----
----MEIVFGIE---------VKE-VDPTS---------HSYV-----------------
-------L----------------------------------IKLLDL-TYD----GMLS
---D-DQGMPKTGLL-------VFILGIIFMHGNR------ASEE---RIWEVLNMI---
-----GVH-AGK----NDFISGEPRKLITEDLVQE------KYLEYQQV-PNSDPPCYEF
----LWCPRAHAETT--KMKVLKFFTRVTGNDPT----A-LPHWYGD---ALKDERESA-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------

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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MSDT-----------------
---------------SE-SGT----------------------------GPTGFQAEASE
KDSG-LKMQTLL-------TVTQ--NLEVSETPKAP------------------KA----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------PEVSEAVKVL-------NAAGVS---------------KAT-----------
-------------EV---------------------------SKAPEAQEAA-ATQASPT
-TKLTDTQVLAA----EK--KSPAADT--KMQNADPE-------AVTVPAT---------
----ETKK-----VSC--------------------------------------------
------------------------------------------------------------
--------------------------------------------------------VA--
-------------------------------DTKV-------------------------
----N-T--KALETEA--------AASQAPADEP---------EP--EGAAAQARENQDT
RPKVK--------------------T---------------------------------K
KARKVKHLNGEEDGS---------------SDQSQASGTTGGRRVSKALMASMARRASRG
PIAFWARRAS----RTRLA----A------------------------------------
------------------------------------WARRALL----SLRSPKARRGKAR
RRA---------------------------------------------------------
-AKLQS-SQEPEAPP-PRDVALL---QGRANDLVK------YLLVKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LKDIIKEYTDVYPEIIERAGYSLEKVFGIQLKEIDKTDHLYI-LLSTLEP
TDAGIL-GTTKDS-PKLG---LLM----------VLLSI----------IF--------M
-NGNR----S-S--EAVIWEVLRKLGLR--PGIHHSLFGDVKKLITDEFVKQK-------
---------YLDYARVPNSNP---P--EYEFFWGLRSYYETSKMKVLKFACKVQKK---D
------PKEWAAQYREAMEADMKAAAEAAA--EAKAR----AEIRARMGIGLGSE-----
----NAAGP--CNWD-------------EADIGPWA-KARIQAGAEAKAKAQESG--GAT
AG------------------ASA--SA--SGGFGASASLTATLTFGLFAGLGGAGASASG
SSGACG-FSYK-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------

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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------MSQH-Q----------------
-----------------KNP-QCLYG-Q----------------CFQT----CSE-IED-
-------------MEVVQVSKALE------------------------------------
-----------------------------------------------------------E
T-----------------------------------------------------------
------------------------------------------------------------
---HLS-SYPLM----PGN--SKEA---P---------------------DAG-------
----------R--------------------------------------PCTP-------
ESQQSFCS---SSFALT-T--TSSSEMNE----------------GFSSQ-EEENST---
--------------------SWAGP------------DSRSVPTNALDEKVISLV-----
-------NFMLFKYHMKEPMT-KADM---KIVINECE-----DHFTEIFLRASEH-----
----MEMVFGLD---------MKR-VDPTN---------HCYG-----------------
-------L----------------------------------FIKLGL-TYD----GVLD
---GE-EGMPKTGIL-------IFILGVIFMKGNS------ATEE---EVWKVLSLM---
-----GIH-AGR----KHVIFGEPRKLITKDFVKE------KYLEYRQV-ANSDPARFEF
----LWGPRAHAETT--KMRVLEFLAKIHGTDPS----S-FPSQYEE---ALQDEEERAR
ARISARSVSTS-------------------------------------------------
------------------------------------------------------------
-----------------------VA--------T----------------ASS----R--
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--------------------------------------MFHR-Q----------------
-----------------K------HE-Q----------------GL-----------ES-
-------------QLREEVPVAK-------------------------------------
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-----------------------EV---P---------------------AAE-------
------------------------------------------------------------
-VSQETSS---SSASIQ-A--TLPSKANE----------------G-SGA-QAEGGQ---
------------S------TSKAYL------------YSKVLLNAKLRKKVTELV-----
-------KFLSFKYITKEPVT-EAEIL--KNVVKEYK-----NYYALIFKHACEC-----
----MEVVFGIE---------VKE-VDAPN---------HSYE-----------------
-------L----------------------------------LKILDL-TYD----GRMS
---N-DEGIPKTGLL-------VLILGVIFMEGNR------ASEK---KIWEVLNVV---
-----GVY-PDQ----HDFICGNPRKFITEDLVSE------KYLEYQLV-PGSDPVCYEF
----LWGPRAHAETS--KMKVLQFFSKVAGSSPT----S-FTALYKD---ALKDEEERAR
ALLASVAIPTT-------------------------------------------------
------------------------------------------------------------
-----------------------PD--------N----------------SGS----GD-
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---------KPS---------------------SFSH-----------------------
------------------PE----------------------------------------
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---------------------------------------------------METQIRRKG
LGCSPADIKRKKKKEDSG--HLGLQVSTMFSEDDFQST---EGAPSGPQI----------
---------QWSQDLPRVQVFRE----------QANQE---DRSPR-RTQRITGG-KV--
-----------------LWGPITQIFPTVRPADLTGVIMPLEQ-----------------
-----------------RSQ-HYKPE-E----------------GLQA----QEE-DPG-
-------------LVGGAQALQAE------------------------------------
-----------------------------------------------------------E
Q-E---------------------------------------------------------
------------------------------------------------------------
---AASFSSTLN----MGT--LEQ------------------------------------
---------VP--------------------------------------AAES---PSPP
QGPQGESS---SPTAMD-S--IFGSLSDE----------------GSSS--QEEKGP---
------------S------TSPDLI------------DPESFSQDILHDKIIDLV-----
-------HLLLRKYRVKELIT-KAEML--GSVIKNYE-----DYFPEIFREASEC-----
----IQLLFGID---------VKE-VDPTS---------HSYV-----------------
-------L----------------------------------VTSLSL-SYD----GIRG
---TE-QSMPKSGLL-------IIVLGVIFMEGNC------VPEE---VMWEVLSIM---
-----GVY-AGR----EHFLFGEPKKLLTHDWVQE------KYLVYRQV-PGTDPACYEF
----LWGPRAHAETS--KMKVLEYIANANGRDPT----S-YPSLYED---ALREEEEGV-
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--------------------------------------------------MLQKPE---S
G--------------------------------------------------ALPSP----
-------QAE----------------------------GEKDGSRDGETQTLT-----A-
-SQKEVPSPFLQE----------SPNEDLGA---------------RREE-G--------
----------------ATASSLTPKGA--RT-LAAKALARRRAYRRLDRTVAELV-----
-------QFLLVKDKKKSPIT-RSEMV--KYVIGDLK-----DLFPEIIARAAEH-----
----LRYVFGFE---------LKQ-FGRKH---------HTYI-----------------
-------L----------------------------------VNKHKPLEEE----EEEV
EEEDLGGDGPRLGLL-------IMILGLIYMKGNS------ARET---QVWEMLRRL---
-----GVR-PSK----YHFLFGYPKRLIMEDFVQQ------RYLNYRQV-PHTNPPECEF
----SWGPRSNLEIS--KMKVLGFVAKLHKKEPQ----H-WPVQYRE---ALADEADRAR
AKAR-AEASMRARA--------RARARATDRAG---------------------------
------------------------------------------------------------
-IY----P------W---------------------------------------------
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--------------------------------------MTLGERN---------------
-----------------ELP---KHE-E----------------DHQD----PRE-VQR-
-------------PVDAQLSEAEE------------------------------------
-----------------------------------------------------------E
EEGLSPPSS------TY---------SPLFSG-------------------------SSP
SSSSS-------------------------------------------------------
-----SSYFALY----PGT--PEEG-----------------------------------
---------SA---------------------------------------AGS---PSPP
QSPLRACP---SPSALA-G--PPWSQSED----------------SF-ST-SDEERW---
------------G------TGVERE----------VAPPVAQEG--FHVKAVDLV-----
-------AFLLHKYRAKQPTS-KAEML--EVITPEYQ-----DDFPVIWGQASEC-----
----MQLVFGLD---------LIE-VDPIA---------HSYV-----------------
-------L----------------------------------VTVLGL-SYD----GMLS
-G--E-QGLPKTGLL-------VLLLGVILLEGDC------VPEE---KVWEAVGVI---
-----GVF-AGK----QHLIYGEPGDLLTHVWVQE------GYVEYRQV-AGSDPTRYEF
----LWGPRAYEETS--KLRVMEYLLHINSRQPA----Y-SPAQSKE---ERRSDEEEGA
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---------------------------------------MSDT-----------------
---------------SE-RGT----------------------------GPTRFQAETSV
KDSG-LKIQTLL-------TVTQ--NLEVSETLKTS------------------KA----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------PEVSEAMKVS-------NAAGVS---------------KAT-----------
-------------GV---------------------------SKAPEAQEAA-ATQASPT
-TKLTDTQVLAV----EK--KNPAADT--KMQSADPQ-------PVTMPAT---------
----ETKK-----VSC--------------------------------------------
------------------------------------------------------------
--------------------------------------------------------VA--
-------------------------------DTKV-------------------------
----N-S--KALETEA--------SASQALADEA---------KP--EGAAAQAQENQDT
RPKVK--------------------A---------------------------------K
KARKVKHLNGEEDGN---------------SDQSQASGTTAGRRVSKALMASMARRASRG
PIAFWARRAS----RTRLA----A------------------------------------
------------------------------------WARRALL----SLRSPKARRGKAR
RRA---------------------------------------------------------
-AKLQS-SQEPEAPP-PRDVALL---QGRANDLVK------YLLVKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LKDIIKEYTDVYPEIIERAGYSLEKVFGIQLKEIDKNDHLYI-LLSTLEP
TDAGIL-GTTKDS-PKLG---LLM----------VLLSI----------IF--------M
-NGNR----S-S--EAVIWEVLRKLGCALAIRIHHSLFGDVKKLITDEFVKQK-------
---------YLDYARVPNSNP---P--EYEFFWGLRSYYETSKMKVLKFACKVQKK---D
------PKEWAAQYREAMEADMKAAAEAAA--EAKAR----AEIRARMGIGLGSE-----
----NAAGP--CNWD-------------EADIGPWA-KARIQAGAEAKAKAQESG--GAS
SG------------------ASA--SA--SGGFGASASLTATLTFGLFAGLSGAGASTSG
SSGACG-FSYK-------------------------------------------------
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---------------------M-------SLVSQNARH----------------------
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------------------CSAEIT------------------------------------
-----------------------------------------------------------A
-DY---------------------------------------------------------
-----------------------------------------------------------G
D--GRGEIQA----------------TNASGS------------P-T-------------
---------------------------------------------------SL------L
----------VADAPQ----CPQAPINPQCV---------------NTSQ-AV-------
---------QDP----N--NLEV--LID-EQSRRLGA---LRVHDPLEDRSIALV-----
-------NFMRMKSQTEGSIE--QSEM--LEFLREDS-----DQFPEILRRASAH-----
----LDRVFGLN---------LRI-IDPQA---------DIYN-----------------
----------------------L-------------------VSKRGS-LTT----DRIA
----GSLDMPKAGLL-------SLVLGHILLNGNR------ARED---SIWDLLIKV---
-----DMW---DEPQRNNNLFGNTRNLLTTDFVCM------RFLEYWPV-FGTNPLEFEF
----LWGSRAHR--EITKM-----------------------------------------
------------------------------------------------------------
--------------------------E-------------------------------AL
K-----------------------F---VS----------------DAHDEEP-------
------------------------WSWPE-QYN------------KALEADKTKER---S
---------------------------------------------------------LT-
AG---L--------E-FWSED---TMNDKANDLVQ------LAISVT-EELLPI--HQ--
------------------------------------------------------------
----DEL---LAHTGKEFEDVFPNILNRATLILDMFYGLSLIEADTSEHIYL-LVQQPES
E-EQVM-LESLGR-PTQE---YVM----------PILGL----------IF--------L
-MGNR----V-K--EGNVWNMLRRFNVD--VGRKHAI--------TCKLMRQR-------
---------YLECRPLSYSNP---V--EYELLWGPRAHLETTKMKILEYMARLYRK---R
------PQDWPEQYREAVE-----------DEEARAKSEANAMFF----LGP--------
---M--------------------------------------------------------
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--------------------------------------MPRGHK---SKLRAREKR-RKA
-RE-----ETQGL-----------------------------------------------
-KV-------------AEATAAEK------------------------------------
-----------------------------------------------------------E
-ECP-------------------------SS-SP-----V---------------LGDTP
ASSP-A-------------------------AGI----------------PQKPQG---A
S--PTTTAAAA-------------------------------------------------
------------------------------------------------------------
-----------------VS----CTESDEGA---------------KS-Q-GE-ENA---
-----------------------------SS-SQGTTSTEKSVKDPIAWEAGMLM-----
-------HFMLHKYKMREPIM-KADML--KFVDEKYK-----DHFPEILNRASHR-----
----LELVFGLD---------LKE-DNPSG---------HTYT-----------------
-------L----------------------------------VSKLNL-TND---GNL-S
----NDWDFPRNGLL-------MPLLGVIFLNGNS------ATEE---EIWKFMNML---
-----GIY-DGE----EHLIYGEPRKFITRDLVKE------KYLKYKRV-PNSDPPRYQF
----LWGPRAYTETT--KMKVLEFLAKVNGTTPR----D-FPFHYEE---ALRDEEERAR
VR-SSIRARRR-TTAA--------------------------------------------
--------------------------T-------------------------------FR
--------------------GRS--R-----------------------AAFS-NSSQPM
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--------------------------------------MPRGQK---SKLRAREKR-QRT
-RA-----QTQDL-----------------------------------------------
-KV-------------GQATAAEK------------------------------------
-----------------------------------------------------------E
-ESP-------------------------SSSSS-----V---------------LGDNP
SSSL-A-------------------------LGI----------------PQKPQR---E
P--RTTPAAAT-------------------------------------------------
------------------------------------------------------------
-----------------MS----GTGPDEGD---------------ES-Q-DE-ENA---
-----------------------------SS-SQASTSTERSLKDPLTRKTKMLV-----
-------QFLLYKYKMKEPTT-KAEML--KIISKKYK-----EHFPEIFRKVSQR-----
----TELIFGLA---------LKE-VNPTT---------HSYI-----------------
-------L----------------------------------VSMLGP-TND---GNQ-S
----SAWNLPRNGLL-------MPLLSVIFLNGNC------AGEE---EIWEFLNML---
-----GIY-DGK----RHLIFGEPRKLITQDLVQE------KYLEYQQV-PNSDPPRYQF
----LWGPRAYAETS--KMKVLEFLAKVNDTTPN----N-FPLLYEE---ALRDEEERTG
AR-PRVAARRG-TTAV--------------------------------------------
--------------------------T--------------------------------S
--------------------TYS--R-----------------------ATSS-SSSHPM
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------------------MSQ--LSKNLGDSSPPAEAPKPP-------------------
----------VYSRPTVLMRAP-----PASSRAPPVPWDPPPIDLQA-SLAAWQAPQPAW
EAPQGQLPAPV---VPMTQPPALGGPIVPAPPLGGPMGKPPT------------------
---------------PGVLMVHP-PPPGAPMAQPPTPGVLMVHPSAPGAPMAHPPP-PGT
PMSHPP-------------------------PPGTPMAH---------------------
-----P---------P------------------PPGTPM----A-------HPPPPGTP
------------------------MV------------HPPPPGTPMAHPPPPGTPMAHP
PPPGTP--MA-------------------HPPPPGTPMAQP---PAPGVLMAQPLTPGVL
MVQPA-------------APGAPMVQPP----PAAVM-------------------TQPQ
PSG---------------------------------------------------------
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------------------------ALWQALPPPP-----P---------------LRQAP
QARLPAPQVQA------------APQVPTAPPATQ-------VPAAPPAGPQVPQP---V
L--PAPLSAP----------------------------------------LS--------
---------AP-----------QAVH--CPSIIWQAPKGQPPVPHE--------------
------------------------------------------------------------
------------------------------------------------------------
---------IPTPMEFQEVQQ-TQ-AL--AWQAQKVP-----THIWQPLPAQEAQRQ---
----APPLVQLE-------QPFQGAPPSQKAVQIQL-PPQQAQAS--GPQAEVPTLPLQP
SWQAPPAVLQAQPGPPVAAANFPLGSAKSLMTP-SGECRASSIDRRGSS-KE----RRTS
SK--ERRAPSKDRM----------IFAATFCAPKA----VSAARAHLPAAWKNLPATPET
FALSSGVF-PAT----SQFQPASLNAFKGPSAASE----TPKSLPYAL---QDPFACVEA
LPAVPWVPQPNMNASKASQAVPTFLM-ATAAAPQ----A-TATT-QE---ASKTSVEPPR
RS-----------------------GKA--------------------------------
--TRK-----KKHLEAQE-DSHGHTLA-------------------------------FH
--D-WQAP----RPWENLN--LSDW--EVQSPIQ-V--SGDWEHPNTPRGLSGWEGPSTS
-RI---------------LSG---WEGPSASWALSAWEGPSTSR-A--------------
---------LGLS---------------ESPGSSLPVVVSEVA-------------S---
VSPGSTATQDNSKVE-AQPLSPL---DERANALVQ------FLLVKD-QAKVPV--QR--
------------------------------------------------------------
----SEM---VKVIIREYKDECLDIINRANNKLECAFGYQLKEIDTKNHAYI-IINKLGY
HTGNLV-ASYLDR-PKFG---LLM----------VVLSL----------IF--------M
-KGNC----V-R--EDLIFNFLFKLGLD--VRETNGLFGNTKKLITEVFVRQK-------
---------YLEYRRIPYTEP---A--EYEFLWGPRAFLETSKMLVLRFLAKLHKK---D
------PQSWPFHYLEALAECEWEDTDEDE-PDT--G--DSA-------HGP--------
---TSRPPPR--------------------------------------------------
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---------------------------------------MAQKPDGGAGLRGFQA-----
--------------------------------------------------------EASV
EDSA-LLVQTLM-------EAIQ--IS-EAPPTSQA--TA--------------------
------------------------------------------AASGPNASPQSSQPPTA-
N------------------------------------------------EKAD-------
------TEVSAAAARPKT------------------------------------------
-----------------------------GF---------------KAQ-----------
-------------NAT----------------TKGPN---DYSQARNAKEMP-KNHSKAA
F-------------------KSQNGTP--KGPHAASD-------FSQAAPT---------
----GKS-AKKSEMAFKGQNST-TKAGPGT---------T-YNFPQSPSANEMTNNQPKT
------------------------------------------------------------
----------------------------------------------A-KAWNDTTKVPGA
-------------------------------DAQT-----------QNV-----------
----NQA---KMADVG--------T------SAG---------ISEADGAAAQTSADGSQ
TQNVE--------------------S---------------------------------R
TIIRGKRTRKVNNLNV---------EENNSGDQRRASLASGNWRSAPVPVTTQQNPPGAP
PNVVWQTPLA----WQNPS----GWQNQTARQTP----PAARQSPPARQTPSAWQNPVAW
QNPVIWPNPVIWQNPVIWPNPI-VWPGPIVWPNPMAWQSTPGWQSPPSWQAPPSWQSPQD
WQG---PPDWQVPPDW-SMPP-DWSFP-SDWPFPPDWIPADWPIPPDWQNLRPSPNLRS-
-SSNSRASQNQGPPQ-PRDVALL---QERANKLVK------YLMLKD-YTKVPI--KR--
------------------------------------------------------------
----SEM---LRDIIREYTDVYPEIIERACFVLEKKFGIQLKEIDKEEHLYI-LISTPE-
SLAGIL-GTTKDT-PKLG---LLL----------VILGI----------IF--------M
-NGNR----A-T--EAVLWEALRKMGLR--PGVRHPLLGDLRKLLTYEFVKQK-------
---------YLDYRRVPNSNP---P--EYEFLWGLRSYHETSKMKVLRFIAEVQKR---D
------PRDWTAQFMEAADEALDALDAAAA--EAEAR----AEARNRMGIGDEAV-----
------SGP--WSWDDIEFELLT-WDEEGDFGDPWS-RIPF----TFWARYHQNARSRFP
QAFTG---------------------P--IIGPSGTATA------NFAANFGAIGF----
--------FWVE------------------------------------------------
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--------------------------------------MPCA-P----------------
-----------------KRW-CYMLE-E----------------GLQS----QSE-TQG-
-------------PVGALLPVAVE------------------------------------
-----------------------------------------------------------E
D-TS-----------------------SS-STCSSSFPSSFPSS----------------
-----------------------------------------------------------S
----SSSCYPLL----LST--PEE--VDD---------------------VTG-------
----------A--------------------------------------PSPP---QSP-
---QSAHP---SPTAMA-S--PPLSQSED----------------DSSSS-RGEEGP---
------------S------TSQALP------------YTASFPRNVIDGKVAELV-----
-------EFLLVKFHTKEPTT-KAEML--NTVLRDYQ-----DHFPVIFSEASEC-----
----MQLVFGVD---------VKE-VDPSD---------HAYV-----------------
-------L----------------------------------VTTLGL-TYD----GMLS
---DE-QSMPKTGLL-------VMLLGVILLQGDC------APEE---DVWEALSVM---
-----GVR-AGR----EHFIYGEPRELITKVWVQE------QYVEYRQV-PNSDRARYEF
----LWGPRAHAETS--KMSVLEFFASAIGSDLR----S-FPVWYEE---ALRDQEERVQ
ARIASTDNATD-------------------------------------------------
------------------------------------------------------------
-----------------------TA--------S----------------ASC----ST-
------------------------------------------------------------
---------VPS---------------------SSSC-----------------------
------------------PE----------------------------------------
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--------------------------------------MPRGQK---SKLRAREKR-RQA
-RG-----GLEDL-----------------------------------------------
-ID-------------ALAILEEE------------------------------------
-----------------------------------------------------------E
-EYP-------------------------PSPSS-----C---------------LKDVS
QS-S-L------------------------DGAAN-------N-------PHGLWE---A
L--SISTSAT-A------------------------------------------------
------------------------------------------------------------
-----------------AS----HTRHTEGV---------------ND-Q-ME-ERP---
-----------------------------RC-MQDLAATDNFPRGPLGEKVIMLV-----
-------HYLLYKYQMKEPIT-KADML--RNVTHMCK-----SQFPVILRRASEH-----
----LELIFGLD---------LKE-VEPNK---------HIYV-----------------
-------L----------------------------------INKLDL-DCD----ARLS
----DETSVPKTGLL-------MTVLGIIFTKGNC------AAEE---EIWKVFNMM---
-----GLY-DGI----EHFIFGEPRKLLTKDLVKE------NYLEYQQV-PNSDPPRYQF
----LWGPRAHAETS--KMKVLEFLAKVNNTVPS----E-FSTWYTE---ALQDEEERAR
AR-VAAKARIS-AM----------------------------------------------
----------------------------------------------------------AG
--------------------ARS--K-----------------------VKSS-NSSQLQ
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--------------------------------------MPRGHK---SKLRAREKR-RQA
-QS-----DTHSV-----------------------------------------------
-QG-------------AQATAAEE------------------------------------
-----------------------------------------------------------E
-GSP-------------------------SSSSP-----P---------------FGGPP
QSSP-A--------------------------CT----------------PQGSQR---A
P--STTTPP-AA------------------------------------------------
------------------------------------------------------------
-----------------AS----GRRAPRGV---------------EG-Q-DE-GGP---
-----------------------------SS-SISRAPSERSRRDPLTRRVIMLS-----
-------QFLLSKYEMQERVT-KGKMM--KIINKRYK-----EHFPEILRRASEY-----
----IEVAFGLD---------VKE-VDSKG---------QSYT-----------------
-------L----------------------------------VSKLEI-TEE---ENL-S
----GGNGFPKTGLL-------MPLLAMIYTSGNR------ATEE---EMWEFLNAL---
-----GVY-DGK----THFIFGEPRKLITKDLVQE------KYLEYRQV-PNSDPPCYEF
----LWGPRAQSEAT--KRKVLEFSAKVKDTYSN----A-FQVFYEE---TWGDEEERAA
GR-EWAGTSV--------------------------------------------------
------------------------------------------------------------
-------------------------T-----------------------ESPA-GPPNPT
EV----------------------------------------------------------
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---------------------------------------------------------SRS
LLNPRYCLPDSTVVLTGCH---------FIMPR---------------------------
----------------------GQKSK-------------------------------SR
--------------------SRAKRQ-QARTELQG---LPEVHH--SAEEAAS--PV---
----------------------DQSDGSN-FP---DGCAPQGVK-S-------------P
---------GSLS---A----------------AVSSTG SVLG---------VRNAVVLA
SKQSSDASQAATSIQ-HTLKDPI---MRKASVLIE------FLLD KF-KMKEAV--TR--
------------------------------------------------------------
----SEM---LAIVNKKFKEQFPEILRRTSARLELVFGLELKEIDPSTQSYL-LVGKLGL
STEGSL-SSNWGL-PRTG---LLM----------SILGV----------IF--------M
-KGNR----A-T--EQEVWQFLNGVGVY--AGKKHLIFGEPEEFI-KDLVQEN-------
---------YVEYHQIPGSDP---P--SYEFLWGPRAYAETTKMKVLEVLAKVNGT---V
------PSAFPNLYQLALRDQAGGARRRAQ-A--RV-------------HSKPLSQK---
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--------------------------------------MPRGQK---SKLRAREKR-RQA
-RA-----ETKGL-----------------------------------------------
-EG-------------AQATAAA-------------------------------------
-----------------------------------------------------------E
GESP-------------------------SSACL-----P---------------FGGEP
QNLP-A------------------------ADIPS-------T-------PLAPQG---A
P--STTNTMA-A------------------------------------------------
------------------------------------------------------------
-----------------DS----CTYPDEDS----------------S-Q-DE-KNA---
------------------------------T-S--SKGTKGRSGDPLNDKVVLMV-----
-------QFLLQKYQKKEPIT-KADML--KLVTKNYK-----PHFNEILRRSSEY-----
----MELAFGVD---------LKE-VDPIR---------HWYA-----------------
-------L----------------------------------VNKLEL-TFD----GTMN
----NEEGMPKTSLL-------MIVLSVIFMQGNC------APEE---EVWKVLNMM---
-----GVY-ADR----KHFIYGEPRKIITEDLVQL------NYLEYQQV-PNSDPPRYEF
----LWGPRAHAETS--KMKVLEFLARLHDTIPS----A-FPSWYEE---ALKDEEERAR
AR-AAARARTAAAM----------------------------------------------
----------------------------------------------------------AS
--------------------ARS--R-----------------------AMAR-NFSHTK
------------------------------------------------------------
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--------------------------------------MPRG-K----------------
-----------------MSP-KCTPD-E----------------HLHT----QSE-TQG-
-------------LESAQVPKPVE------------------------------------
-----------------------------------------------------------E
T-----------------------------------------------------------
------------------------------------------------------------
---LPSSSLLPI----SGN--LKEV---P---------------------AAK-------
----------V--------------------------------------LSAP-------
EGPQSFCS---SPGDIT-A--TSSNKPDE----------------GTRSK-EEKKSL---
------------S------TSEVTA------------NPKNVPIDALDRKVAFLV-----
-------NFLLMKYRVKELVR-KADIC--KIIIKDDE-----DHFHEIFLRASER-----
----MEMIFGLD---------VKE-VDPTC---------HCYG-----------------
-------I----------------------------------VIKLGL-TYD----GMMY
---PP-LGLPKTGLL-------IVMLGVIFMNDNC------ASEE---EVWKVLNIT---
-----EIY-SGQ----KHFIYGNPKKFITQHLVKE------KYLEYRRV-ADSDPARYEF
----LWGPRAHAEVR--KMEFLEYLAKVHGTEPQ----S-YPSQYED---ALQDEERAE-
------------------------------------------------------------
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-----------------------------------------------------MSEQSKD
LSD---------------------------------------------------------
------------------------------------------------------------
--------PNF----------------------------A---------------AED-P
NSEM--------------------------QVS-----------------PADPVA---V
P--PPVSPAET----------PAGPPSAPEGP------------V---------------
----AAPQAS--------------------------------------------------
------PPP--------------AERFEEVD---------PKIL-QQA-A-EE--GR---
----------------------AHQPQ--SPARQ--M-PAPPAPAQLVQKAHELM-----
-------WYVLVKDQKRMVLW-FPDMV--KDVMGSYK-----KWCRSILRRTSLI-----
----LARVFGLH---------LRL-TNLHT---------MEFA-----------------
-------L----------------------------------VKALSPEELD-----RVA
----LNNRMPMTGLL-------LMILSLIYVKGRG------AREG---AVWNVLRIL---
-----GLR-PWK----KHPTFGDVRKIITEEFVQQ------NYLKYQRV-PHLEPPEYEF
----FWGSRANREIT--KMQIMEFLARVFKKEPQ----A-WPSRYRE---ALEQARALRQ
ANLAA----------------------------------HCPRSSVSED-----------
------------------------------------------------------------
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---------------------------------------MDRRNDYGYRMPTFQ--G---
--------PLPPP--GSLGLP----------------------------FSSDVQTETTE
KDNV-LLMRTLL-------STSK--DT-----PIASRSKK-------------SKTKKTS
IKAI----------TKT-TPT--PPPVPPANDIAGNKPKVTLQALNLPMFTQISQASST-
T------------------------------------------------EAAN-------
------IQASVTA-QTKKA-KTKRVTP------KLSLNGTEDVTTQLKSPLKALNLPVTS
PTIQS---PIANESANSLAL-IAVSKPKKAP---------------KAK-----------
-------------KAA----------------NKTIPSATEISLASTATHTA-TTQGQTA
-KETASIQATAATIRAKKTSKAKRTTA--KTTNTDTE-------YVESSNA---------
----LEGS----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------S
RQIEA--------------------S---------------------------------T
VGLRPKKPKGKKVANKGP---------N------------SASELSEAPPAIQMVTNHAL
SVTVRIRRGS----RARKA----ATKTRAQESQA----QITDQGAQAKMATPQ-ASISAL
ETQ------------VA------------AAVQALADDYLAQL----SLEPTTRTRGKRN
RKVRSKPRATPLCKGE-SRPTKSMELC-GRNSNLFHFVTPDIFFFSLMKSKHPNGEERT-
GSNYRRIPWGRRPPP-PRDVAIL---QERANKLVK------YLLVKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LKDVIQEYDEYFPEIIERASYALEKMFRVNLKEIDKQSSLYI-LISTQES
SAG-IL-GTTKDT-PKLG---LLM----------VILSV----------IF--------M
-NGNK----A-S--EAVIWEVLRKLGLR--PGVRHSLFGEVRKLITDEFVKQK-------
---------YLEYKRVPNSRP---P--EYEFFWGLRSYHETSKMKVLKFACKVQKK---D
------PKDWAAQYREAVEMDVQAAAVAVA--EAEAR----AEARAQMGIGEEAV-----
------AGP--WNWDDMDIDCLT-REELGDDAQAWN-RFSF----EIDSRAQENADSTNN
LNFNQGPSTRNSFSDGANISFGGITNP--SGGFGGMPNSNGG--------FGGIP----N
SN----------------------------------------------------------
-------------------------------------GGFGGIPNSNGGFGGIPNSNGGF
GGIPNSNGGFGGRNGITFGSAPNTSANFSSAASISFGDTSNSSTSFSGGASISFSGTPST
SATFCNTASISFGSASSTSTSFSSGASISFGGAPNTSTSFSS----------------TA
TISFGGAPSTNTSFSSTASISFGGAPSISSSFSGGSSISFGGSPS--TSTSFSGGASISF
GGAPCTSASF-----NGFGGTLSSTAAGFSGALSTSTNFGSAPTTSTVFSGAVSTTTGFG
GTLSTSVCFGSSPCSGAGFGGTLSTSICFGGSPSTNNGFGG----TLSTSVSFGASSSTS
SDFGGTLSTSVSFGGSSGTS-AGFGGALNSSTSFGGAISTSAGFGNALNSSASFGSAIST
GFGGALNSSASFGGAINTSTGFGGALNSSASF----------GGAISTSAGFGNALSTSA
SFGSVLNGSSGFGGAISTSASFGNALNNSAGFGGAISTSASFGGA---------------
-------------------------LNGSSGFGGAISTSASFGGALNGS-AGFGGAISTS
ASFGGALNGSAGFGGAISTSASFDGALSNNAGFGSAISTSASFDGALNNSAGFGSAISTS
ATFGGGLNNSAGFGGAISTSASFGGGLNNSAGFGSAISTSASFGGGLNNSAGFGGAISTS
ASFGGAISTNPDFGGAFSTSVGFGGALS-TTDFGSTHSNSISFGSAPTTSVSFGSSHSTN
LCFGGAPSNSLCFGSASNTNLCFGGSSSTNSCFSGATSANYSEGHSTSAIFSFGNGLSTN
AGFGNGLGTSAGFGSSLGTSTGFGGSLGPSASFNGGLGTSNGFGGGLGTSTDFGGGLSPN
ADFGGGLGTSAGFDGGLNTSTDFGGGLGTNAGFGDGLGSNTGFGGGLVTNDGFAGDLSAN
NGFGSTLGTGAGFGVSLSTGDGFGNGSNASFDRGLNTIIGFGSDSNTSSSFTGEPSTGSS
FSNGPSSIVGFSGGPSTGAGFCNGPST-GSFGGGPSTGAGFGGPSTGG------------
----------------------------------GFGGPSTAAGFGGGLSGSAGFG----
-------GGLNSSAGFSGG-PSTGTGFGGGGTNLGACGFSYG

------------------------------------------------------------
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------------------------------------------------------------
--------------------------------------------------------MAE-
----------------------------------------------------------GS
YS-----V-Q-------SGSYAVEDMEEGRGEAGR-EEEMVEGNDYE----EFGAFGGYG
ALTSFDIHL--LRAFGSLG-----------------------------SGLRILSNEPWE
LENP-VLAQTLV-------EALQ--LDPDTLANETAARAA-------------NVARSAA
---S----------NRA-ARAA--------------------AAAARRSFNQV---MGNH
R------------------------------------------------Q-PT-------
------PQASGRVSQPVPDA---RAP--------------------GAAPETPPASPQIS
-----PPMSGPSTMAAPGAPAASSAPSPAAS---------------QAQ-----------
-------------EAA----------------AEGPSAARTSSQAPSAAETD-ATRAPTA
FLGQ----------------------------NDVFD-------FTQPAGV---------
----SGMAFPRPKRPAPAQEA--ATEGPSD---------TS-GGPQAASAGEVEATRPKM
T-----------------------------K-----------------------------
------------------------------------------------------------
--------------------------------------------------------SGKA
LAKTRWVEPQNVVAAA--------AAKA-KTATS---------APEPEGAAA---SAQHS
AD-----------------------P---------------------------------W
ARMGGKRTKKSKHLDEEH--------ESSE-EEREPVAVPQTWRASQPPLP---------
---------A----R---------------------------------------------
----------------------------------------AQVA----------------
-----------------PRPP-----------------------------M----A----
-ATSQIPSRHVLCLP-PRNVTLL---QERANKLVK------YLMIKD-YKKIPI--KR--
------------------------------------------------------------
----SDM---MKDVIREYDEHFPEIIERATYTLEKKFGIHLKEIDKEEHLYI-LICTRDS
SAR-LL-GKTKDT-PRLS---LLL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPFLGDLRKLITDDFVKQK-------
---------YLEYKKIPNSSP---P--EYEFLWGLRARHETSKMRVLRFIAQNQNR---D
------PREWKARFLEAVDDAFKTMDVDMA--EEHAR----AQLRAQMNIGDEAL-----
------VGR--WSWDDIQAELLT-WDEDGDFGDAWA-RIPF----AFWARYHQYILNSNR
ANRRATFFSWIQHR----------------------------------------------
------------------------------------------------------------
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---------------------------------------MDRRNDYGYRVPPFQ--G---
--------PLPPP--GSLGLP----------------------------LPPDIQTETTE
EDSV-LLMHTLL-------AATK--DSLAVDPPVVSRPKK-------------SKTKKAP
IKAI----------TKA-APA--APPVPTANEIATDKPKITLQALNLPVITQISQASPT-
T------------------------------------------------EVTN-------
------TQVSSVTAQPKKANKMKRVTAKAAQG-SQSPTGREGGATQLKSPLQVLNLPVIS
QNIHA---SIANESASSQTL-ITSIKPKKAS---------------KAK-----------
-------------KAA----------------NKAIASATEVSLAPTATHTA-TTQGQIT
-NETASIHTTAASIRTKKASKARKIIA--KVINTDTE-------HIQAANV---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------TETAT
RQIEA--------------------S---------------------------------V
IAIRPKKSKGKKAACRGP---------N------------SVSEISEALLATQMVTNQAL
AATLRVKRGS----RARKA----STKARATESQT----PNADQGAQAKMASAQ-TNVSAL
ETQ------------VA------------AAVQALADDYLAQL----SLEPTTRTRGKRN
RK-----------------------------------------------SKHLNGDERS-
GNNYRRIPWGRRPAP-PRDVAIL---QERANKLVK------YLLVKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LRDVIQEYDEYFPEIIERASYALEKMFRVNLKEIDKQSSLYI-LISTRES
SAG-IL-GTTKDT-PKLG---LLM----------VILSV----------IF--------M
-NGNK----A-S--EAVIWEVLRKLGLH--PGVRHSLFGEVRKLITDEFVKQK-------
---------YLEYKRVPNSRP---P--EYEFFWGLRSYHETSKMKVLKFACKVQKK---D
------PKDWAVQYREAVEMEVQAAAVAVA--EAEAR----AEARAQMGIGEEAV-----
------AGP--WNWDDMDIDCLT-REELGDDAQAWS-RFSF----EIEARAQENADASTS
VNFSRGAGTRAGFSDGASISFNGAPSS--S----G-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------GPGITFGGAPSSSASFSNTASISFGGTLSTSS----------------
--------------------SFS------------------S----------------AA
SISFGGAPSTSTSFSSEASISFGGTPCTSASFSGGVSSSFSGPLN--TSATFSGAASSGF
GG------------------TL-STTAGFSSVLSTSTSFGSAPTTNTVFSSALSTSTGFG
GTLSTSVCFGGSPSSSGSFGGTLSTSICFGGSPCTSTGFGG----TLSTSVSFGGPSSTS
ANCGGTLSTSICFDGSPSTG-AGFGGALNTSASFGSALNTS-------------------
-------------------------------------------------AGFGGAMSTSA
DFGSTLSTSVCFGGSPGTSVSFGSALNTSAGFGGAVSTSTDFGG----------------
------------------------------------------------------------
-----TLSTSVC------------------------------------------------
----------------------FGGSPSTSAGFSGALNTNASFGCAISTSAGFSGAVGTS
AGFSGVPSTNPGFGGAFNTSAGFGGALSTTTDFGGTPNNSIGFGAAPSTSVSFGGAHSTS
LCFGGAPSTSLCFGSASNTNLCFGGPPSTSACFSGATSPSFGDGPSTSTGFSFGNGLSTS
AGFGGGLNTSAGFGGGLGTSAGFSGD------------------------------LSTS
SGFDGGLGTSAGFSGGPGTSTGFGGGLGTSAGFSGGLGTGAGFGGGLVTSDGFGGGLGTN
ASFGSTLGTGAGFSGGLSTSDGFGSRPNASFDRGLSTIIGFGSGSNTSTGFIGEPSTSTG
FHSGPSSIVGFSGGPSTGVGFCSGPSI-SGFSGGPSTGAGFG------------------
------------------------------------------------------------
-------GGPNTGAGFGGG-PSTSAGFGSGATSLGACGFSYG

------------------------------------------------------------
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------------------MLPLSSGL----RTPLTRSIMSDH-Q----------------
-------------DQQ------------------------------------NQG-LQA-
-------------QREVQNPRAQE------------------------------------
-----------------------------------------------------------E
--EA-----------------------AASF-----------------------------
------------------------------------------------------------
--------SAGI----PGP--LEEG---A---------------------AAA-------
----------G--------------------------------------ASP--------
----------------A-S--GEGHQPDE----------------G-SSS-QGAEGP---
------------A------PPQELE------------DP-EVLRDALEDKMSDLI-----
-------HLMLLKYRIKEPIT-KEEMM--SSVVQQYG-----DHFAEIFREATDC-----
----LELVFGID---------VKE-VDPPS---------NCYI-----------------
-------L----------------------------------VTSMGL-SYH----EELD
---DE-NCLPKVGLL-------IIILGFIFLEGNS------APEE---VIWAALGMM---
-----GVH-DGW----EHFIYGEPRQLITHHWVQE------GYLVYQQV-PQSDPARYEF
----LWGPRAHAETT--KMKVLEYVAKINKRDPR----S-FPYLYEE---ALRDEEEEE-
------------------------------------------------------------
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-------------------------------------SQKIS-K----------------
-----------------KSK-IFKLE-E----------------ALHS----QCK-VQG-
-------------LVNARDLEAKK------------------------------------
-----------------------------------------------------------E
A-AT-----------------------SFFPSCST-------------------------
------------------------------------------------------------
---SSASCSYLT----SSN--TKGV--SV---------------------AGG-------
--------------------------------------------------------QISC
HGPHRASC---SATS--VV--TPSVELDQ----------------G-SSS-QEEKNP---
------------C------TLKILP------------DAESLIRDTIDDKVADLV-----
-------QLLLLKYRMKEPVT-KAEMQ--NCIIKIYE-----NYFPVIFNKVYEC-----
----MQLVFGID---------IKK-VDSSG---------QSYV-----------------
-------L----------------------------------VPSLGL-TYD----GMLG
---DI-LSMPKVGLL-------INILGVIFLDGNC------APEE---DVWEVLNAM---
-----GVY-DGK----EHFIYGEPRKLLTEDWVRE------GYLECRQV-PHSDPARYEY
----LWGPRAHAETT--KMKILEFLAKINDTVPS----A-LPIWYEE---ALRDEEARAK
VKVRATEWAE--------------------------------------------------
------------------------------------------------------------
--------------------------------------------------ANS----RA-
------------------------------------------------------------
---------M-F---------------------SCFF-----------------------
------------------PK----------------------------------------
------------------------------------------------------------
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---------------------------------------MSDT-----------------
---------------SE-SGA----------------------------GLTSFQAEASE
KDSS-SMMQTLL-------TVTQ--NVEVPETPKAS------------------KA----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------PEVSEDVKVS-------KTSGVS---------------KAT-----------
-------------EV---------------------------SKTPEAQEAP-ATQASST
-TQLTDTQVLAA----EN--KSLAADT--KKQNADPQ-------AVTMPAT---------
----ETKK-----ISC--------------------------------------------
------------------------------------------------------------
--------------------------------------------------------VA--
-------------------------------DTKV-------------------------
----N-T--KAQETEA--------AASQAPADEP---------EP--ESAAAQSQENQDT
RPKVK--------------------A---------------------------------K
KARKVKHLDGEEDGS---------------SDQSQASGTTGGRRVSKALMASMARRASRG
PIAFWARRAS----RTRLA----A------------------------------------
------------------------------------WARRALL----SLRSPKARRGKAR
RRA---------------------------------------------------------
-AKLQS-SQEPEAPP-PRDVALL---QGRANDLVK------YLLAKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LKDIIKEYTDVYPEIIERAGYSLEKVFGIQLKEIDKNDHLYI-LLSTLEP
TDAGIL-GTTKDS-PKLG---LLM----------VLLSI----------IF--------M
-NGNR----S-S--EAVIWEVLRKLGLR--PGIHHSLFGDVKKLITDEFVKQK-------
---------YLDYARVPNSNP---P--EYEFFWGLRSYYETSKMKVLKFACKVQKK---D
------PKEWAAQYREAMEADLKAAAEAAA--EAKAR----AEIRARMGIGLGSE-----
----NAAGP--CNWD-------------EADIGPWA-KARIQAGAEAKAKAQESG--SAS
TGASTST------NNSA--SA--SAST--SGGFSAGASLTATLTFGLFAGLGGAGASTSG
SSGACG-FSYK-------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
----------------------------------SRVIMPRGHQ---SKLRTRGKR-RQA
-QG-----DTHSV-----------------------------------------------
-QG-------------AQPSQSSH------------------------------------
-----------------------------------------------------------A
-A----------------------------------------------------------
--------------------------------PT--------------------------
------------------------------------------------------------
----------------------------------------------------------TQ
GSQRAPSTS---TGAIAAS----GRRAPSGA---------------EG-Q-DE----G--
----------GP-----------------SS-SSARARNERSQRVRLTSRVIMLS-----
-------QFLMYKYEMQRQIT-KREML--KFINKRYK-----EHFPEILRRTSEY-----
----LELVFGLD---------VKK-VDSKV---------KNYA-----------------
-------L----------------------------------VSKLDL-PNN----GRVR
----AGRGLPKTGLL-------MTLLGVILLKGNC------ATEK---EIWEFLNMM---
-----RVF-AGR----KHLIYGEPRKLITKDLVKL------KYLEYRPV-PNSDPPRYEF
----LWGPRAHAETS--KIKILEFLAKVNDIVPS----A-LSCLYEE---AVRREKGQHR
KD-F-SHA----------------------------------------------------
-----------------------------------------------------------K
--------------------YWIRV------------------------------HS---
------------------------------------------------------------
------------Q-----------------------------------------------
------------------SNKNI---K-INEMDEQ------FLLYKY-KMKQPI--TK--
------------------------------------------------------------
----ADM---LKIVKQKYKDQFPEILKRAAERIEIVFAADVKEVDPITQSYA-LVSKMDL
PNDGRV-CGRKGL-PKTG---LLM----------TLLGV----------IF--------L
-KGNR----A-T--EEEIWEFLKTMRVF--AGKKHFIYGEPRKLITKDLVKLK-------
---------YLEYRQVPNSDP---P--SYEFLWGPRAHAETTKMKVLEFLAKINDT---D
------PSAFASRYEEALRDEEERAQAIDA-ARAGSSAT---------------------
------------------------------------------------------------
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------------------------------------------

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---------------------------------------------------METQFRRGG
LGCSPASIKRKKKREDSG--DFGLQVSTMFSEDDFQST---ERAPYGPQL----------
---------QWSQDLPRVQVFRE----------QANLE---DRSPR-RTQRITGGEQV--
-----------------LWGPITQIFPTVRPADLTRVIMPLEQ-----------------
-----------------RSQ-HCKPE-E----------------GLQA----QEE-DLG-
-------------LVG-AQALQAE------------------------------------
-----------------------------------------------------------E
Q-E---------------------------------------------------------
------------------------------------------------------------
---AAFFSSTLN----VGT--LEE------------------------------------
---------LP--------------------------------------AAES---PSPP
QSPQEESF---SPTAMD-A--IFGSLSDE----------------GSGS--QEKEGP---
------------S------TSPDLI------------DPESFSQDILHDKIIDLV-----
-------HLLLRKYRVKGLIT-KAEML--GSVIKNYE-----DYFPEIFREASVC-----
----MQLLFGID---------VKE-VDPTS---------HSYV-----------------
-------L----------------------------------VTSLNL-SYD----GIQC
---NE-QSMPKSGLL-------IIVLGVIFMEGNC------IPEE---VMWEVLSIM---
-----GVY-AGR----EHFLFGEPKRLLTQNWVQE------KYLVYRQV-PGTDPACYEF
----LWGPRAHAETS--KMKVLEYIANANGRDPT----S-YPSLYED---ALREEGEGV-
------------------------------------------------------------
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--------------------------------------MPHS-Q----------------
-----------------KSQ-SHKLQ-V----------------GLQA----EKE-AQG-
-------------LVGSQVPVAEE------------------------------------
-----------------------------------------------------------K
--A---------------------------------------------------------
------------------------------------------------------------
---TASLLSSLI----QGT--PEVV---P---------------------TAG-------
----------A--------------------------------------QSVP-------
QSSQGACS---SSTTIE-A--IPLSKSNE----------------G-SSQ-E--ESP---
------------SSF---------Q------------APMFLLSDVLNKKLAQLV-----
-------QLMRVKYVTKEPVT-KAEIL--ENVMKEHE-----DHFPVIFSKACEC-----
----MEIVFGIE---------AKE-VDPTS---------HSYV-----------------
-------L----------------------------------QKTLGL-TYD----GMLN
---D-GQSMPKTGLL-------IYILGVIFMEGNR------ATEE---RIWKVLNMI---
-----GVC-AGQ----KDFIYGEPKKLITKDLVEE------KYLEYHQV-PNSDPPCYEF
----QWGPRAHAETS--KMKILKFFSKVNGVDPT----S-FPYWYEE---ALRDEKER--
--AAAGDATSA-------------------------------------------------
------------------------------------------------------------
-----------------------MA--------S----------------V---------
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----LRYDFGFD---------LQL-LDLEH---------HTYA-----------------
-------L----------------------------------VNSPRATAAA-------D
KDRDLGAESAKLGLL-------MVILGLIYMKGNC------VREA---QVWDLLGRL---
-----GVW-PLK----HYHHFGYPKKLLTEEFVEQ------QFLNYRQV-PYSSPPEYEF
----TWGLRSSRDIS--KMQVLNFVARLQKKEPQ----H-WPAQYQE---ALADEAYRER
VRAR-EEAFFTARA--------RAVARYATATR---------------------------
------------------------------------------------------------
-LG---------------------------------------------------------
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------------------------------------------------------------
--------------------------------------MPRGQK---SKLRACKKR-RQV
-RE-----ELQDL-----------------------------------------------
-VG-------------AQATAAVG------------------------------------
-----------------------------------------------------------E
-VFH-------------------------SPSSL-----C---------------FKSSP
AAGS-----------------------------YS-------V-------SQGPQG---A
I--STSTTAA-S------------------------------------------------
------------------------------------------------------------
-----------------VS----HTRSNESA---------------DN-Q-VE-ERP---
-----------------------------RS-SQAQPTAEPFPRGPLDEKVVKLV-----
-------HYLLYKYQMKELIS-KAGML--RNVIQMYR-----NHFHEILKRASEH-----
----LELVFGLD---------LKE-VDPNR---------HIYV-----------------
-------L----------------------------------VNKLEL-SYD----AMLS
----DDEGVPKTGLL-------MTILGVIFTKGNC------AAEE---QVWQVLNVI---
-----GLY-AGM----EHFIFGEPRKLITEDLVKE------EYLEYRQV-ANSDPPRYEF
----LWGPRAYAETS--KMKVLEFLAKVHYTVPS----A-FPAWYEE---ALQDEEERAQ
AR-AAARAHTA-AM----------------------------------------------
----------------------------------------------------------AS
--------------------ARA--R-----------------------AMTS-AHSKGI
TNE---------------HSR-AMTNVHS-RA-IASVRSKATQT-I-------------P
---------PTPN---K-----------------V-------------------------
------------------------------------------------------------
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----------------------LGQVSTMFSEDDFQST---EGAPSGPQI----------
---------QWSQDLPRVQVFRE----------QANQE---DRSPR-RTQRITGG-EV--
-----------------LWGPITQIFPTVWPADLTGVIMPLEQ-----------------
-----------------RSQ-HCKPE-E----------------GLQA----QED-NPG-
-------------LVGGAQALQAE------------------------------------
-----------------------------------------------------------E
Q-E---------------------------------------------------------
------------------------------------------------------------
---AASFSSTLN----VGT--LEE------------------------------------
---------VP--------------------------------------ATES---PSPP
QSPQGESS---SPTAMD-S--IFGSLSDE----------------GSSS--QEEEGP---
------------S------TSPDLI------------DPESFSQDILHDKIIDLV-----
-------HLLLCKYRVKGLIT-KAEML--GS----------------IFREASEC-----
----MQLLFGID---------VKE-VDPTS---------HSYV-----------------
-------L----------------------------------VTSLSL-SYD----GIQG
---DE-QSMPKSGLL-------IIVLGVIFMEGNC------VPEE---VMWEVLSIM---
-----GVY-AGR----EHFLFGEPKKLLTHDWVQE------KYLVYRQV-PGTDPACYEF
----LWGPRAHAETS--KMKVLEYIANANGRDPS----S-YSSLYED---ALREEEEGV-
------------------------------------------------------------
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--------------------------------------MSKLQ-----------------
-----------------KNP-ECAAD-Q----------------G-QT----CEK-THS-
--------------QIAAVC----------------------------------------
-------------------------------------------------------R---D
VEEP----------------------------CISSHLMAT------------------S
LKDQTC---------------------------------------EGT------KVSRDV
EEPCHS-SHSLM----ASN---QN------------------------------------
---------DP--------------------------------------ADET---PSTS
GGLQSPCD---SLRNSG-G--D-LSNQEQ----------------GSP-------VN---
------------P------PC--QP------------ATMNVPVMSVDSKVDFLV-----
-------NYMLYKYQMKEMMS-KIDIL--RLIVREDE-----NRFHEILMRSAER-----
----MEMVFGIG---------VKE-VDPVN---------HVYA-----------------
-------L----------------------------------FIKLGL-TYD----GM--
RS-DE-FSFPKTGLL-------IIILGVVFLKGNR------ATEE---EIWEALNPM---
-----GIY-AGV----NNFIFGDPRQLITNEFVKE------QYLVYQPV-ADSDPVRYEY
----VWGPRARAETS--KMKVLEFVAKVYGTHPA----T-FQSQYQE---ALIEEEERAL
ALILDSAGLSS-------------------------------------------------
------------------------------------------------------------
-----------------------R-------SRA----------------SSS--A----
------------------------------------------------------------
---------MGC---------------------SF-------------------------
------------------PRM---------------------------------------
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--------------------------------------MPRGQK---SKLRAREKR-RQA
-RE-----EPRDV-----------------------------------------------
-TG-------------AQANVEGE------------------------------------
-----------------------------------------------------------E
-ESP-------------------------SSSSP-----Q---------------VGDTL
QKSS-T------------------------TEAPG-------G-------QQEAES---G
P--PAAAAAA-V------------------------------------------------
------------------------------------------------------------
-----------------PH----ARSNDEGA---------------SN-Q-VE-ERP---
-----------------------------SA-SQGREATLYYLRGPLERKVAMLV-----
-------HYLLYKYQMKEPIT-KADML--RNVIQMYK-----NHFSEILRRASDH-----
----LELVFGLD---------MKE-VDPNR---------NVYV-----------------
-------L----------------------------------INKLEL-GCD----GRSG
----DIRGVPKTGLL-------MTVLGVIFTKGNR------ATEE---QVWEVLNMM---
-----GVY-DGR----KHFIYGEPRKLLTKDLVKE------KYLEYRQV-ANSDPPRYEF
----LWGPRSYAETS--KMKVLEFLAKIHDTVPS----A-YPGWYEE---ALKDEEERSR
AR-AAAKARTA-AM----------------------------------------------
----------------------------------------------------------AS
--------------------ARS--K-----------------------VPSS-PK----
------------------------------------------------------------
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--------------------------------------MSQD-Q----------------
-----------------ESP-QCTDD-Q----------------HLQK----HGE-AQG-
-------------SQDAQGSKAVE------------------------------------
-----------------------------------------------------------E
T-----------------------------------------------------------
------------------------------------------------------------
---SHYSSHTLM----PAN--LSEA---A---------------------SAE-------
----------A--------------------------------------PSAP-------
EGPRGFFT---SSIAII-A--TLWRRCDV----------------GFSSE-E-EESS---
------------S------TSEDES------------DDENVPADALDQKVALLV-----
-------NFMLIKYRMKEPIR-KADML--KIVVQ--------EEFPEILLRASER-----
----IEMVFGLD---------VKE-IDHSS---------QRYG-----------------
-------L----------------------------------FIKLGL-TYD----GMES
---GE-DSMPKTGIL-------ILILGVIFMKGNR------ATEE---EVWEVLNMT---
-----GIY-SGE----EHFIFGDLRKLITHDLVKE------NYLEYQQV-ANSDPPRYEF
----LWGPRAHAETT--KMKILEFVAKVHGTDPS----S-FPSQYEE---AMRDEEER--
------------------------------------------------------------
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------------------------------------------

------------------------------------------------------------
------------------MSL--VSQNSRRRRGGRAN---AR------------------
--------------------RNNGKGHPAAVPGPDVPRDRNDPKILQ-GLRAS-------
---EG-----------------PGT------------SMLPT------------------
---------------PREGPSA---------SVPPTAS---EGSSAPRQFII-SQG-PNT
SEMPTS---------------R-KG----RGASRPPAVS---------------------
-----AGLNTAMSITASEGPN------SPVPPTAPKGSKA---YE-------HLPVSEGL
AI----------------------SE-QRHSDGGP--NMEPTL--------GEGPGISVP
PTFSEESGIS------------------------DEGLSIF-------MS--PNISEGPG
INEPYSVSEDPS--------TS---VP-----PTDSNG------------LG---INLPP
T------FGEGLSISMLFSALEEPDIFAPPPSA---------------EGLFAS------
------------------------------------------------------------
------------------------------------------MSPPSGEIQSSWVSPIIM
EGCNVNV---------PPTSKKGLRTSVP---------------SAACESPST-------
------------------------------------S---------------AEGLSSSL
----------SSI----------------------------------------------S
AEGFCSS---------LAP-----------------------------------------
------------------------------------------------------------
---C------------------------AAEG--SCELLP---------------CGEGR
STSE---LHCL------GEGSS-TSQMSLAAEGPSA--S---G---M---PT--------
---------------------------EANNP----------------------------
------EEALSCCA------SER--RNKSTSRALQK------------------------
-----------------------AKDPSVRP---------------K-------------
-------REDRFLDFQVLRDSKNSNSITIMGLGTSRVALTLKPQDPMEQNVAELL-----
-------QFLLLKDQTKYPIK-ESDMR--EFIDKDYR-----HQFPEILRRAAVH-----
----LECIFRFE---------LKE-LDTEE---------HIYI-----------------
-------L----------------------------------LNKLGPVPFE-----GLE
----DVPNGPKMGLL-------MMILGHILLNGNQ------AREA---DIWEMLWRF---
-----GVQ-RER----RLSVFGNVKRLLSVEFVWQ------RYLDYRPL-TDCVPVEYEF
----YWGPRSRAETT--KMKILKFMAKIYNKDPM----D-WPALYNE---ALEEDADRVV
VNN---------------------------------------------------------
------------------------------------------------------------
----FRVARPFRRPLFAE----------VAPE------------------LDA-S-----
------------------------------------------------------------
--------------------------------------G---------------------
---------SKYSPH-SWPESRL---ESKARKLVQ------LFLLMD-STKLPI--PK--
------------------------------------------------------------
----KGI---LYYIGRECTKVFPDLLNRAARTLNHVYGTELVVLDPRNHSYT-LYNRREM
EDTEEI-MDSPNR-PGNN---FLM----------QVLSF----------IF--------I
-MGNH----A-R--ESAVWAFLRGLGVQ--NGRKHVI--------TCRYLSQR-------
---------YLDSLRVPDSDP---V--QYDFVWGPRARLETSKMKALRYVARIHRK---E
------PEDWPEQYREAMEDEANRAEAGRR-PL----------IVRNLR-----------
------------------------------------------------------------
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--------------------------------------MPLRHTS---------------
-----------------QLW---KL--------------------EED----PGE-AQG-
-------------LVNAQLPEAED------------------------------------
-----------------------------------------------------------E
DEVSSPPYL------CS---------SSS----------------------------SSP
SSSSSC------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------PP
QSPQSAGP---SPSGRA-P--SGWSQVEF----------------AGPSG-PEEEIW---
------------N------PWEVPE----------YAQPSAQGGDTMLMSGADLV-----
-------GFLLRKYLNKQPTS-QAEVL--EVLSPDMQ-----DAWPEIWGQACEC-----
----MQLVFGVE---------VKE-VDPIA---------HSYV-----------------
-------L----------------------------------VTVLGL-SYD----GMLS
-G--E-QGLPTTGLL-------VLLLGVILLEGDR------APEQ---EVWEALGVM---
-----GVF-AGR----QHVIYGEPRELLTHVWVQE------GYVEYRQV-AGSNPARYEF
----LWGPRAHEETS--KLQVMEYVLWVNSRWPV----S-SLAPFDE---EEWA------
------------------------------------------------------------
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QSSQGACF---SPTATS-A--TPLSQSDE----------------N-SRS-QEEEEP---
------------ST------SQTPP------------DPESSLSDELNNKVAELV-----
-------QFLCVKHVTKKPTT-KAEML--RSVMRKHK-----DNFPEIFSKVCEC-----
----MEVVFGIE---------EKD-MDPTR---------RSYE-----------------
-------L----------------------------------VKTFNL-TCN----GMLS
---N-EGGMPKTGFL-------ILILGMILMEGNC------APEE---KIWKALNTM---
-----GVY-AGQ----EDFIYGEPRKLITNDLVEE------QYLQYRQV-PHSDPPHYES
----LWGPRAYAETS--KMKVLEFFAKISGTDPT----S-FLFWYEE---ALRDER--AQ
ARTVPRD-TSA-------------------------------------------------
------------------------------------------------------------
-----------------------MA--------S----------------ENS----SV-
------------------------------------------------------------
---------VSS---------------------SLFC-----------------------
------------------PE----------------------------------------
------------------------------------------------------------
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--------------------------------------MPRGQE---SKRRAREKR-RQA
-RG-----EDRCL-----------------------------------------------
-RG-------------AQATAAEK------------------------------------
-----------------------------------------------------------E
-KLP-------------------------SSSSP-----A---------------CQSAP
QSFP-A-------------------------AGI----------------PQESQR---A
S--YP-SSPAAA------------------------------------------------
------------------------------------------------------------
-----------------VS----LTSSEEGA---------------KG-Q-KG-ESP---
-----------------------------NS-FHGPSSSESTERDLLNRKTGELV-----
-------QFLLNKYIRKEPIT-REAML--KVINRTYK-----QHFPEILRRSAEN-----
----VEVVFGLY---------LKE-MDPSR---------QSYV-----------------
-------L----------------------------------VSKLDF-PDQ---GSL-G
----DDGGFPRSGLL-------MVLLSTIFMHGNR------ATEE---EMWECLNAL---
-----GMY-KGR----KHFLYGEPQELVTKDLVRE------GYLEYRQV-PSSDPPRCEF
----LWGPRAHAETS--KMKVLEFVAKLNDTVAS----T-YKSQYEE---ALREEEEQAR
AR-AAARASAR-AR----------------------------------------------
----------------------------------------------------------VS
--------------------RSS--Q-----------------------P----------
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--------------------------------------MPRGRK---SKLRARAKR-RQA
-QK-----EPQNL-----------------------------------------------
-VG-------------AQATAGVT------------------------------------
-----------------------------------------------------------E
-RAH-------------------------SSSSN-----R---------------VRSAP
QRST-A------------------------SG----------------------------
---ATTTTAA-A------------------------------------------------
------------------------------------------------------------
-----------------VS----HAR----Y---------------NN-Q-VR-ERP---
-----------------------------TS-SQAQVAFGHLCSAPLDEKVVTLV-----
-------QYLLLKYQMKERIW-EADVM--RNIIRLPK-----SHFYEILMKASEY-----
----MELIFGLD---------IRK-LDPNR---------HIYI-----------------
-------L----------------------------------VNKLDI-SYD----AKLG
----DDEGIPKTGLL-------MTILGVIFARGNC------ATEE---QIWQILNIM---
-----GIY-DGR----RHFIFGDPRKLITKDLVKA------KYLIYREV-PNTIPPRHEF
----LWGPRAHAETS--KMKVLEFLAKVHDIVPT----A-LTSWYAE---ALRDEEERAQ
TR-AAARARIR-AI----------------------------------------------
----------------------------------------------------------AD
--------------------ARS--R-----------------------ALLI-RPSHTS
KV----------------------------------------------------------
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--------------------------------------LPLEQ-----------------
-----------------RSQ-HCKPK-E----------------GLEA----RGE-ALG-
-------------LVGAQAPATEE------------------------------------
-----------------------------------------------------------Q
E-T---------------------------------------------------------
------------------------------------------------------------
----ASSSSTVV----EVT--PGE------------------------------------
---------VP--------------------------------------ATES---LGPP
----QTST---LPTTIN-C--TLWSQSDE----------------DSSN--QEEEGS---
------------S------AFPDL---------------ETRFQAALSRKVAELV-----
-------HILLLKYRAREQFT-TAEIL--ESVMRNCQYWPGTYFFPIIFSKASEY-----
----LQLVFSIE---------VME-VVPIG---------HLCI-----------------
-------L----------------------------------VTCLGL-SYS----GLLG
---DN-QIMPTTDLL-------IIILAIMAREGNS------APEE---KVWEELSVL---
-----ELS-GRR----EDSVLANPSKLLTQVLVQE------NYLEYRQV-PFSDPACYEF
----LWGPRALIETS--YVKVLHHMLKMSEGPRI----S-YPPLHEW---ALREGEE---
------------------------------------------------------------
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--------------------------------------MLLGQ-----------------
-----------------KSQ-RYKAE-E----------------GLQA----QGE-APG-
-------------LMDVQIPTAEE------------------------------------
-----------------------------------------------------------Q
K-A---------------------------------------------------------
------------------------------------------------------------
----ASSSSTLI----MGT--LEE------------------------------------
---------VT--------------------------------------DSGS---PSPP
QSPEGASS---SLTVTD-S--TLWSQSDE----------------GSSI--NEEEGP---
------------S------TSPDPA------------HLESLFREALDEKVAELV-----
-------RFLLRKYQIKEPVT-EAEML--ESVIKNYK-----NHFPDIFSKASEC-----
----MQVIFGID---------VKE-VDPAG---------HSYI-----------------
-------L----------------------------------VTCLGL-SYD----GLLG
---DD-QSTPKTGLL-------IIVLGMILMEGSR------APEE---AIWEALSVM---
-----GLY-DGR----EHSVYWKLRKLLTQEWVQE------NYLEYRQV-PGSDPVRYEF
----LWGPRALAETS--YVKVLEHVVRVNARVRI----S-YPSLHEE-----ALGEEKGV
------------------------------------------------------------
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--------------------------------------MSHLQ-----------------
-----------------KSP-ECEAD-P----------------G-QT----FEE-TQG-
-------------LRVAAVS----------------------------------------
-------------------------------------------------------Y---D
TGEP----------------------------CSSSHFMAS------------------S
LKDQTC---------------------------------------EETQGLEIKQVSRDV
EEPGPS-SYSLM----ASN---QD------------------------------------
---------DL--------------------------------------ADQI---PSTS
GGL--------------------SDQENQ----------------GNP-------VN---
------------P------PC--QP------------DTTNTPVMSIDSKVDFLV-----
-------NYMLYKYQMKEIMS-MTDIL--KLIVKEDE-----DRFPEILMRATER-----
----MEMVFGLD---------VKE-IDPVN---------HCYA-----------------
-------L----------------------------------FIKLGL-TYD----GM--
RS-DQ-YSFPKTGLL-------ILILGIVFMKGNR------STEE---EIWEVLNPM---
-----GIY-AGM----NHFVFGDPRQLITDEFVRE------QYLTYQPV-ANSDPVQYEY
----VWGPRTRAETS--KMKVLEYVAKVHGTDPI----A-FRSQYEE---ALIEEEERAL
TMILDRAGSSS-------------------------------------------------
------------------------------------------------------------
-----------------------L-------SGA----------------SSG--A----
------------------------------------------------------------
---------MGS---------------------SF-------------------------
------------------PDI---------------------------------------
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--------------------------------------MPHA-P----------------
-----------------KRR-RYMLE-E----------------GHEA----QGE-AQG-
-------------LVCAQAPVADE------------------------------------
-----------------------------------------------------------E
D-TS-----------------------SSSSTSSSSFPSSFLSS----------------
-----------------------------------------------------------S
----SSSCYPLI----SST--PEE--AYA---------------------LPG-------
----------T--------------------------------------SSSS---QSP-
---QSSCP---SPMAVA-S--APLSQADD----------------G-SCS-QKEEGL---
------------S------TSQPLP------------DTESFPKNVIDDKVSELV-----
-------EFLLHKYRTKELTT-KAEML--NIIIKDVQ-----GHFPVIFSEASEC-----
----MQLVFGID---------VKE-VDPSN---------HSYV-----------------
-------L----------------------------------VTTLGL-TYD----GMLS
---DE-QSMPKTGIL-------ILILSIIFMEGGC------APEK---VVWEALNVM---
-----GVY-AGR----EHFIYGEPRELITKVLVQE------GYLEYQQV-PNSEPDRYEF
----QWGPRAHMETS--KMSLLEFLASVNGSDPR----S-FPVWYEE---ALRDQEGRAQ
ARMTTTDNTTA-------------------------------------------------
------------------------------------------------------------
-----------------------MA--------S----------------TSS----SA-
------------------------------------------------------------
---------MSS---------------------SCFC-----------------------
------------------PE----------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
--------------------------------------MADSH-----------------
-----------------NTQ-YCSLQ-E----------------SAQA----QQE-----
-------------LDNDQET----------------------------------------
------------------------------------------------------------
--------------------------------------METS------------------
------------------------------------------------------------
---EEEE-DTTT----SNK--V--------------------------------------
----------Y--------------------------------------GSGI---PSPP
QSPQRAYS---PCVALA-S--IPDS------------------------P-SEEASI---
------------K------GSGGLE------------DPLYLLHNAQNTKVYDLV-----
-------DFLVLNYQMKAFTT-KAEML--ESIGREYE-----EYYPLIFSEASEC-----
----LKMVFGLD---------MVE-VDPSV---------HSYI-----------------
-------L----------------------------------VTALGI-TYD----GM--
MT-DV-LGMPKTGIL-------IAVLSVIFMKGNY------VSEE---IIWEMVNNI---
-----GLC-GGR----DPYIHKDPRKLISEEFVQE------GCLKYRQV-PNSDPPSYGF
----LWGPRAFAETS--KMKVLQFFASINKTHPR----A-YPEKYAE---ALQDEIDRTK
AWILNRCSNSS-------------------------------------------------
------------------------------------------------------------
-----------------------DL-------------------------LT---F----
------------------------------------------------------------
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---------------------------------------MDRRNDHGYRMPPVQ--G---
--------PLPTP--GSLGLH----------------------------FPPDVHAETTE
EDSV-LLMHTLL-------AATK--DPLAMDPPVANRPKK-------------SKTKKAP
IKAV----------TKT-IPVAPPPPVPSSNVITINKPKIPLQVLKLPISPQISQASAT-
T------------------------------------------------EAAN-------
------IQASSVTTQSKKANKTKRAAAKAAQG-PQSPTGSESVTTQIKSPLKALYLSVIP
QTTQA---PLASESANSQAL-VASIKPKKAS---------------KAK-----------
-------------KAA----------------DKAIYNSTEISLASNTIHTA-TTQGQMT
-NEATNTQATTASVRTKKASKDKRATV--KGTNTDTV-------LGAPD-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------TTERGI
RQIEA--------------------S---------------------------------A
AAIRAKKSKGKKAANEGI---------H------------FAYEISEAPPAVQMVTNQAL
AATLQVKRGS----RAQKT----SPKAQVAKTQI----QIVDQGAQAKMASSQ-TNLSTL
ETQ------------VA------------AAVQALADDYLAQL----SLEPTTRTRGKRN
RKF-----------------------------------------------KHLIGHERG-
GRNYRWNPWGQRPPP-PRDVAIL---QERANKLVK------YLLVKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LKDVIQEYDEYFPEIIERASYALEKMFRVNLKEIDKQSSLYI-LISTKES
SAG-IL-GTTKDT-PKLG---LLM----------VILSV----------IF--------M
-NGNK----A-N--EAVIWEVLRKLGLR--PGVRHSLFGEVRKLITDEFVKQK-------
---------YLEYKRVPNSRP---P--EYEFFWGLRSYHETSKMKVLKFACKVQKK---D
------PKDWAAQYREAVEMEVQAAAVAVA--EAEAR----AEARAQMGIGEEAV-----
------AGP--WNWDDMDIDCLT-REELGDDAQAWS-RFSF----EIEARAHENADASTN
IDFSRGAGTAASFHNGASISFSGAPSP--SGG----------------------------
------------------------------------------------------------
------------------------------------------------------------
--------GFGGRT----------------------------------------------
------------------------------------------------------------
GISFGGTPSTSASFSSTASVSFGGTPYTSASFGGGVSSSFSGPLI--TTTSFSGGASPGF
------------------GGTL-STTAGFSGALMTSTSFGSAPSTGAVFSGALSTSTGFG
GTLSTSVCFGGSPNSGASFGGTLSTSIYFGGSPSTSTGFDS----ILSTSVSFSGSSSTI
ADFGSTLSTSICFSGSPNPS-ASFGGAISTSVGFGGALNTSAGFSSA-------------
------------------------------------------------------------
-----VGGSPG-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------FGGAPTTNSGFGGMFSTS
ADFTGALSTTTDFASAPSASIGFGAGPS--------------------------------
---------TSFFGNVPNTNLCFGGPPSTSACFSGATSASFGNGLSTSVGFNFGDGLSAG
TGFGGGLSTSTGF--------------------NGGLGTSTGFNGG--------------
------------------------------------LGTSAGFGGGLISSDGFGGGLGTN
AGFGSTLGTSAGFSGSLNISDGFGGGPNTSFDGGLSTIIGFGSGSNTSIGFTGEPSTSIG
FNGGPSSIVGFGGGLNTGAGFSGGPSN---------------------------------
------------------------------------------------------------
-----------------------GAPFGGGATSLGACSFSYG

------------------------------------------------------------
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-----------------KSP-QCTPD-Q----------------HLQT----QSE-TQG-
-------------LESAQVTKPVE------------------------------------
-----------------------------------------------------------E
T-----------------------------------------------------------
------------------------------------------------------------
---LSSLSALLI------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------SATA------------NPENVLIDALDRKVAFLV-----
-------NFLLMKYRMKELVR-KADIW--KMIIQDDE-----DHFHEIFLRACEH-----
----MEMIFGLD---------VKE-VDPTR---------HCYG-----------------
-------I----------------------------------SIKLGL-TYD----GMMH
---PP-EGLPKTGLL-------ILILAEIFMNDNC------VSEE---EVWKVLSKT---
-----KIY-SGQ----MHFIYGHPKELVTKYLVME------KYLEYRQV-ADSDPARYEF
----LWGPRAHAEVR--KMEILEFLARVHGTEPQ----S-YPSQYED---ALRDEE----
------------------------------------------------------------
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--------------------------------------MPRGQK---SKLRAREKR-RQA
-RE-----GPGHL-----------------------------------------------
-VA-------------AQATVPEE------------------------------------
-----------------------------------------------------------E
-ESH-------------------------P-SPS-----H---------------VEDAP
QSSP-A------------------------TETPG-------N-------PQVTGK---V
S--TSTTAAA-A------------------------------------------------
------------------------------------------------------------
-----------------AP----NTKFNEGA---------------SN-Q-ME-EKP---
-----------------------------NA-SQAKDTTEQWRKGPVDKKVAMLV-----
-------YYLLYKYQMKEPIT-KADML--RNVIQMYK-----NQFHEILRKASEH-----
----LELVFGLD---------VKE-VDPNR---------NTYV-----------------
-------L----------------------------------VNKLES-SCD----DKVN
----YNSGVPKTGLL-------MTVLGVIFTKGNC------ATEE---QVWEVLNMM---
-----GLY-DGI----KNFIYGEPRKLITNDWVKE------EYLEYRQV-ANSDPPRYEF
----LWGPRAYAETS--KMKVLEFVAKIHDTVPT----A-FPVWYEE---ALKDEEERAR
AR-VVAKACTA-AV----------------------------------------------
----------------------------------------------------------AS
--------------------ARG--K-----------------------AMAS-SFSCPK
------------------------------------------------------------
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--------------------------------------------------QVCEC-----
----LEIVFGIE---------VKE-VDPTS---------HTYV-----------------
-------L----------------------------------VKILDL-TYD----GMLS
----DARGMPKTGLL-------VLILGMIFLEGNR------ASEE---KVWDMLSVI---
-----GVH-AGQ----EDFIYGEPRKLITEDLVRE------KYLEYRQV-PDSDPPCYEF
----LWGPRAYAETS--KMKVLQFFAKVSGADCA----S-FPSWYEE---ARRDDEERAQ
LAVD-DAAMAS-A-SPSVTSSSLSGPE---------------------------------
------------------------------------------------------------
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-----------------------------------------------------MSEQSKD
LSD---------------------------------------------------------
------------------------------------------------------------
--------PNF----------------------------A---------------PDA-A
NSEV--------------------------QES-----------------SEIPVG---V
P--PPTSPAAI----------VAEAPEAPEGP------------M---------------
----AARQAS--------------------------------------------------
------PPP--------------PERLEDID---------PKIL-EQA-I-EE--GR---
----------------------AHNPD--SPVRQ--L-PTPPAPAQVVQKAHELM-----
-------WYVLVKDQKRMVLW-FPDMV--KDVMGSYK-----KWCRSILRRTSLI-----
----LARVFGLH---------LRL-TNIHT---------MEFA-----------------
-------L----------------------------------VKALSPAELD-----RVA
----LNNRMPMTGLL-------LMILSLIYVKGRG------AREG---AVWNVLHIL---
-----GLR-PWK----KHSTFGDVRKIITEEFVQQ------NYLKYQLV-PHSDPPEYEF
----FWGSRANREIT--KMQIMEFLARVFKKDPQ----A-WPSRYRE---ALEQARALRE
ANLAA----------------------------------HCPRSSVSGD-----------
------------------------------------------------------------
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---------------------------------------------------METQFRRKG
LGCSPANIKRKKKREDSG--DLGLQVSTMFSEDDFQST---ERAPYGPQI----------
---------QWSQDRPRVRIFRE----------QANQE---DRSPR-RTQRIPGGEQV--
-----------------LWGPITQIFPTVRPADLTRVIMPLEQ-----------------
-----------------RSQ-HCKPE-E----------------GLQA----QKE-DLG-
-------------LVG-AQALQAE------------------------------------
-----------------------------------------------------------E
K-E---------------------------------------------------------
------------------------------------------------------------
---AAFFSSILN----VGT--LEE------------------------------------
---------LP--------------------------------------AAES---PSPP
QNPQE-EF---SPTAMG-A--IFGSLYDE----------------GSSS--QEKEGP---
------------S------TSPDLI------------DPESFSQDILHDKIIDLV-----
-------HLLLRKYRVKGLIT-KAEML--GSVIKNYE-----NYFPEIFREASAC-----
----MQLLFGID---------VKE-VDPTS---------HSYV-----------------
-------L----------------------------------VTSLNL-SYD----GIQC
---NE-QNMPKSGLL-------IIVLGVIFMEGNC------IREE---VMWEVLSIM---
-----GVY-AGR----EHFLFGEPKRLLTQDWVQE------KYLVYRQV-PGTDPACYEF
----LWGPRAHAETS--KMKVLEYIANANGRDPT----S-YPSLYED---ALREEGEGV-
------------------------------------------------------------
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--------------------------------------MSRY------------------
----------------GKHP-RLSLE---------------EGVNFQN----PTE-MD--
--------------EFPLVPTPEKEEREEEEV--KEEEEDNN-----KQKNKED------
---NKEKKEEEEE----KGK---------------------------EDEKEECGDEVND
EENEK----------GEEEADLASIFFSSSNVSFPTFTPP-------------------S
---PSS---------------------------------------S-------SSSSSSS
SSSSSSSFFSLF----QSN--LGGNE----------------------------------
---------DY--------------------------------------AAGM---LSIF
QNAQSFFP---SP--------TLGENLDE----------------ATSHQ-EES--S---
------------G------AIQSPE------------DPEALLNIVIQEKATDLV-----
-------FLFIYKYRMKEPIT-LSEIY--EVVTKDYE-----DHFAVIFIEASKC-----
----LEMTFGID---------IKE-SDLLS---------SAYV-----------------
-------F----------------------------------VNSLNL-TYE----DMLN
---DN-DRLPRNAFL-------IVILGVIFIEGNC------ASEE---RIWEFLKLV---
-----GVY-DGE----VHFICGDPREFLTVDLVQQ------NYLEYRQV-PDSQPPCFEF
----LWGSRAYAETT--KMKVLEFLAKMNGCDPT----D-FSIWYEE---ALRDEEERAW
AINDSADGSPT-------------------------------------------------
------------------------------------------------------------
-----------------------TW------FLE----------------R---------
------------------------------------------------------------
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--------------------------------------MPRGQK---SKLRAREKR-RDT
-HG-----QPQSL-----------------------------------------------
-PG-------------PQTTVEKQ------------------------------------
-----------------------------------------------------------K
-EPP-----------------------TSTIS-S-----D---------------YRGAH
PKSS----------------------------DAS-------V-------PQESQG---A
S--PTGSPDAGVSCSKSDVAA----KGQDDKS------------AGTSPDASVPQESQ-G
TSPTDSLDAGASC---------SKS--------DVAAKGQDEKNASTSPDASV-----PQ
GSQGVSSTA---SLDAGIS----CSKSDMAG---------------LNQ---DGESA---
-----------------------------IT-SQRAAFFKTTDRDPLNRKASALV-----
-------HFLQEKFEKKEIIL-KADML--KRISRKYK-----EYLPEILKKTSNH-----
----LAVVFGVE---------LKE-MDSSG---------ESYT-----------------
-------L----------------------------------VNKLGL-SGE----GILS
----GVNGLAKSGIL-------VSLLSFIFMRGNR------ATEK---EVWDFLGVL---
-----GIY-DGI----THSIYGEPRKIITEDLVQD------KYLEYRQV-CNSDPPCYEF
----LWGPRAHAETS--KMRVLRALASINNTAPG----S-YPHLYEE---ALVDEVQKAL
RVNF--------------------------------------------------------
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--------------------------------------MSHIQ-----------------
-----------------RHD-PG-FE-D-----------------QL-------------
---------------E--------------------------------------------
---------------------------------------------------EEVP-----
--A---------------------------------------------------------
---------------------------------------------------------AEE
VGTWEK------------------VA----------------------------------
---------AA--------------------------------------ES---------
-SQETASS----SASSQ-A--SASSKASE----------------GSGGE-AEGG-Q---
------------S------TSKACL------------RTKLMLNSKFQKKVIDLV-----
-------KFLSSKYVTNEPVT-EAEIL--KSVGKKHK-----GYYSLIFKHACEC-----
----LEVVCGIE---------VKE-VDALN---------HTYL-----------------
-------L----------------------------------LKVLDL-TYD----GRIS
---NE-EGIPKTGLL-------VLVLGIIFMEGNR------ASEK---KIWEVLNIV---
-----GVY-PDQ----HDFICGNPRKFITEDLVLE------NYLVYQPV-PYSDPPSYEF
----LWGPRAQAETS--KMKVLQFFCKVAGSNPA----S-FTALYKE---ALEDEEERAR
ALLASTAIS---------------------------------------------------
------------------------------------------------------------
-----------------------TA------VDN----------------SGS--G--D-
------------------------------------------------------------
---------KPS---------------------SVSH-----------------------
------------------SE----------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------MSQ--LSKNLGDPSPPEEAPKPA-------------------
----------VYSRPTVLMRAP-----PASSRAPPVPWDPPPIDLQA-SLAAWQAPQPAW
EAPQGQPPAPV---APMSQPPSLGGPMVQAPPLGGPMGKPPT------------------
---------------PGVLMIHP-PPPGAPLAQPPTPGVLMMHPSAPGAPMAHPPP-PGT
PMAHPP-------------------------PPGTPMAH---------------------
-----P---------P------------------PPG---------------------TP
------------------------MVHP--PPPGTPMAHPPPPGTPMAHPP---------
PPPATP--MA-------------------HPPPPGTPMAQP---PAPGVLIPQPLTPGVL
MVQPP-------------APGAPIAQPP---PPAPLM-------------------AQPP
PLGAPMAKPPGPGVLMIHPAGSRPPITQPPATG---------------APIVQPPAP---
--APPAQPMASWAPQAQPLILQIQSQVI----R-------APPPV---P-----------
-------Q---GPQAPPAQLATPPGWQSTSPGWQAPPQGWPATPLGWSTTQVTWPGPT--
----------IAWQAPLSV-RPGPPPIRP-------------GPPPIRPGPPPIR---QA
PPP---------------------------------------------------------
------------------------------------------------------------
--------IRQAPPLIRQAPP-PI------------------------------------
-----------------------------------------------------------R
--------------PAPQVLATPPPLWQALPPPP-----P---------------LRQAP
QTRLPTPQLRAA------PPIRAAPQVPTAPPAPQ-------MPTAPPAVPQAPPT---V
M--PAPLPVP----------------------------------------LSA-------
----------P-----------QAVH--CPPIIWQAPKGQPPAPQE--------------
------------------------------------------------------------
------------------------------------------------------------
---------MPTSMEFQEVQQ-AQASL--AWQAPKAQ-----GQFWQSLTTQEAQRQ---
----GPPLVQLE-------QPFQGAPASQKALQIQL-PTQQAQLS--GSQAELPSMQLQP
SWQGPPAALQGQPGAPVAGANFPMGSAKSLMTP-SGESRASSIDRRTSS-KD----RRTS
SK--ERKAPLKDRM----------IFGGTFCAPRA----MPPAGAHLPAPWKNLPATSET
FNATARVF-PST----SQFQPASSNAFKGPSATSE----APRSLPFTL---QDPFACIEA
LPAVPWVPQPNANSSKASKAGPSILM-ATAAAPQ----V-MAIT-QE---ASKTSAEPPR
RS-----------------------GKA--------------------------------
--TRK-----KKHLNTEEGDSSGKMLS-------------------------------MR
--H-WQAP----RRWENLD--LNDW--EVQTPIR-F--LCDWEGPSTSRILSGWEGLSTS
-QI---------------LSG---WEGPSTSWALSAWEGPSTSR-A--------------
---------LGFW---------------ESPVSPPSLIISELP-------------T---
LAQGFGATQYDPKLE-TQPLSPL---DERANALVQ------FLLVKD-QAKVPI--KR--
------------------------------------------------------------
----SEM---VKFIIREYKDECLEIISRASHKLECVFGYQLKEIDPQNHSYI-LINKG--
RKGDTG-ASSLDR-PKLG---LLM----------VVLSL----------IF--------M
-KGNC----V-R--EDLIFTFLCKLGLN--IRETHGLFGNTKKLITEVFVREK-------
---------YLEYRRIPFTEP---E--EHEFLWGPRAFLETSKMIVLKFLARLYKK---D
------PRCWPYQYYEALAECESEDLDEDE-SGP----DDKT-------DDP--------
---TSSPPPH--------------------------------------------------
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--------------------------------------MPRGQK---SKLRAREKR-HQA
-RG-----DTHSV-----------------------------------------------
-QG-------------AQAPAAEE------------------------------------
-----------------------------------------------------------E
-GSP-------------------------SSYSP-----P---------------FGGSP
PSSP-A-------------------------AHI----------------PQGCQR---V
P--PTTTAI-VA------------------------------------------------
------------------------------------------------------------
-----------------AL----GTRAIGGA---------------EG-Q-GE-GGP---
-----------------------------SS-SEATAPTERSQRDPLIRRVSMFL-----
-------QFLLHKYKMKEPVT-KAEMM--KIINKRYK-----EHFPDILRRASEH-----
----MEVVFGLD---------LKE-VDSKS---------QSYV-----------------
-------L----------------------------------VSKLEI-TKE---ENF-I
----GARGFPKIGLL-------LPLLGIIYMNGNR------ATEE---KIWETLNVL---
-----GIY-DGK----RHFIFGEPRKLITKDLVQE------KYLEYRQV-PNSDPPCYEF
----LWGPRAHIEAN--KTKVLEFLAKISATDSR----A-FQALYEE---TWVDEAKRAA
AG-EWAGAGLN-AR----------------------------------------------
----------------------------------------------------------AR
--------------------ARF--R-----------------------AKSS-RS----
------------------------------------------------------------
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---------------------------------------------------METQIRRKG
LGCSPADIKRKKKKEDSG--HLGLQVSTMFSEDDFQST---EGAPSGPQI----------
---------QWSQDLPRVQVFRE----------QANQE---DRSPR-RTQRITGG-KV--
-----------------LWGPITQIFPTVRPADLTGVIMPLEQ-----------------
-----------------RSQ-HYKPE-E----------------GLQA----QEE-DPG-
-------------LVGGAQALQAE------------------------------------
-----------------------------------------------------------E
Q-E---------------------------------------------------------
------------------------------------------------------------
---AASFSSTLN----MGT--LEQ------------------------------------
---------VP--------------------------------------AAES---PSPP
QGPQGESS---SPTAMD-S--IFGSLSDE----------------GSSS--QEEKGP---
------------S------TSPDLI------------DPESFSQDILHDKIIDLV-----
-------HLLLRKYRVKELIT-KAEML--GSVIKNYE-----DYFPEIFREASEC-----
----IRLLFGID---------VKE-VDPTS---------HSYV-----------------
-------L----------------------------------VTSLSL-SYD----GIRG
---TE-QSMPKSGLL-------IIVLGVIFMEGNC------VPEE---VMWEVLSIM---
-----GVY-AGR----EHFLFGEPKKLLTHDWVQE------KYLVYRQV-PGTDPACYEF
----LWGPRAHAETS--KMKVLEYIANANGRDPT----S-YPSLYED---ALREEEEGI-
------------------------------------------------------------
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----------------------------------------------INDKVADLV-----
-------DFLLLKYRTKELTT-RAEML--SSIIREHQ-----DHFAVIFREASEC-----
----MQLVYGIE---------VKE-VDPTS---------HTYV-----------------
-------L----------------------------------VTNLGL-TYD----GM--
VS-DE-HSMPKTGLL-------ILILSIIFSEDDC------APEE---KIWEALNAM---
-----GVY-AGM----EHSIYGEPRELLTRDWVQE------QYLEYRQV-PNSDPARYEF
----LWGPRAYAETT--KLKILEFLAQVNGSDPR----S-YTHWYQE---ALREEEQRAQ
EGTVNQSG----------------------------------------------------
------------------------------------------------------------
------------------------G------LLM----------------WS---A----
------------------------------------------------------------
---------VL----------------------KSDEQ-NKL------------------
----------------VWPDVE------PPQ---V------L--------LETT--TK--
------------------------------------------------------------
----AEM---LSKVIKEHQDHFPEIFSAASECMQLVFGIDVKEVDPRAHTYV-LVATLGL
TYDGMV-GDGHRF-PNTG---LLV----------TLLWL----------IA--------A
-EGDC----A-S--EEEVWKALHVRGVH--DGKEHWLYGEPRELLTNVWVQEK-------
---------YLEYRQVPNSNP---A--RYQFLWGPRAHAETTKLKVLEFLLRVYRR---D
------PTSNLSLSEEALSGEE--------------------------------------
------------------------------------------------------------
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--------------------------------------MPRGQK---SKLRAREKR-RKA
-RD-----EIQNL-----------------------------------------------
--G-------------AQAAAAEK------------------------------------
-----------------------------------------------------------E
-ESA-------------------------ASS----------------------------
---------------------------------------------------SSALG---S
T--PPSSL--AA------------------------------------------------
------------------------------------------------------------
----------------GAS----CTKSKKCG---------------KS-K-RQ-ERK---
-----------------------------MA-SQAAAAAERAQRDPIIRKAGILV-----
-------QFMLYKYKMQEPIT-KVEML--KVVHKRYR-----EHFPEIFKRASER-----
----VQLVFGLD---------LKE-VNPGG---------QSYT-----------------
-------L----------------------------------VSKLDF-EDD---GSL-S
----SLWSFPKNGLL-------MPLLGVIFLNGNS------ASEE---EIWEFLNIL---
-----GVY-DGK----KHFIFGEPRQLITEELVQD------EYLVYQQV-PNSDPPRFEF
----LWGPRAHAETS--KMKVLEFLAKINDTVPS----A-FPSHYEE---ALKEEQEKCG
AE-AAAE--P--STSS--------------------------------------------
--------------------------E-------------------------------AR
------------------------------------------------------------
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--------------------------------------MPRGQK---SKHRAREKH-RQA
-QA-----ETQGL-----------------------------------------------
-HD--------------QATTSGE------------------------------------
-----------------------------------------------------------E
-ETT-------------------------SSSPP-----D---------------SESGP
SSSS-A-------------------------AGI----------------SKGPQG---A
Q--GTTSAASGAIRKRSGVGRA--------------------------------------
------------------------------------------------------------
--------ARSRSVV------------GVGA---------------EG-Q-VQEGE----
-----------------------------NS-SQASAAAESSHTDLLTWKAEMLV-----
-------QYMLCKYKARELIK-RSEML--KAVTRRYR-----EQFPEILSRASEH-----
----MEMVFGLV---------LKE-VRPN S---------HCYT-----------------
-------L----------------------------------VSNLDL-SDS----ES MR
----GDWGLLKNGLL-------MPLLGVIYLNGHR------ASEE---EIWKFLNIL---
-----GIY-DGR----RHFIFGDTRKLITEDLVRE------GYLEYRQV-PGSDPPRYEF
----LWGPKALSETS--KTKVLQILAKVKDLVPN----A-LLPHYEE---AWREEVESSR
TRAVA-GTSPSASASV--ASGS---PSASARPG---------------------------
-----------------------PSA----------------------------------
-L--------------------ARPGPSAASSAGP-----SA---------SASGSPSAS
ARP-----------------G-PSASASG-SPSAS---ARPGPS-A-----SASGSPSAS
---------ARPGPSASASGS-LSALASAHSRATSSCS----------------------
------------------SRP---------SVV---------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------MQAPNVPGLPAAMPGPDVPEGPSDPQILQ-GLCAP-------
---EG-----------------PGT------------SVPST------------------
---------------PGEGPST---------SVLPAAS---EGSCASGPPTV-SEG-PNI
DLSIAA---------------S-ER----PNNPLPPTAS---------------------
-----EGSSASEH-----------------------------------------------
----------------------------PSVTEGLNTSELPLS--------NEGPSCFVP
PTSGEGLSTY-------------------LPPTSGEGPSTSVP------P--T-TSEGLS
ISAPPTSGEELS--------IL-----------------------------------MRP
T------VSEGPGINMPPFSGQGLSTSVPPTPD---------------ESPSTS------
------------------------------------------------------------
------------------------------------------VS----------------
DAPGTSV---------LPPSDEGRSIFTP---------------PTPDEGR---------
------------------------------------------------------------
------------------------------------------------------------
----STS---------LAL----T------------------------------------
-----------------------------------------------------------A
FEEP-----------------------------VASVLLL---------------SGNSS
KI-SGLQ--TS------GEGPS-TSRVSSATE--GL--G---L-SGM---PT-ASE----
N--PGALLS---------------------------------------------------
------------SSA-----SGSPNSSKCS-VALPNLGVAKA------------------
------------------------SADSEGP---------------K-------------
-------GAEGPVEFQVLRDHKNSNSITIMGLSTSQVALTLKPQDPMEQNVAELL-----
-------QLLLVKDQSKYPIR-ESEMR--QHIVKEYR-----NQFPEILRRVAAH-----
----LECIFRFE---------LRE-LDPEE---------RTYI-----------------
-------L----------------------------------LNKLGPVPFE-----GLE
----DSPNGPKMGLL-------MMILGEIFLNGNQ------AKEA---EIWEMLWRM---
-----GVQ-RER----RLSIFGNPKRLLSVEFVWQ------RYLDYRPI-TDCTPVEYEF
----FWGPRSHLETT--KMKILKFMAKIYNKDPM----D-WPEQYNE---ALEEDAIRAA
ADD---------------------------------------------------------
------------------------------------------------------------
----WQAVPQFRRPFFEE----------IPAD------------------LLS-PD----
-AE---------------------------------------------------------
---------VSGY-------------------------P---------------------
---------SKYPPH-SWPESRM---ESKARKLVQ------LFLLMD-STKLPI--PK--
------------------------------------------------------------
----KGI---LYYIGRECSKVFPDLLNRAARTLNHVYGTELVVLDPRNHSYT-LYNRREM
EDAEEI-IDSPNR-PGNN---FLM----------QVLSF----------IF--------I
-MGNH----A-R--ESAVWAFLRGLGVQ--TGRKHVI--------TCRYLSQR-------
---------YIDSLRVPDSDP---V--QYEFVWGPRARLETSKMKALRYVARIQRK---E
------PQDWPEQYREAMEDEANRAQAGHR-QI----------LIHNVR-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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--------------------------------------------------MLQKPR---N
R--------------------------------------------------GRSGG----
-------QAE----------------------------RDRDWSHSGNPGASR-----AG
EDARVLRDGFAEE----------APSTSRGP---------------GGSQ-G--------
------------------SQGPSPQGA--RR-AQAAPAVGPRSQKQLELKVSELV-----
-------QFLLIKDQKKIPIK-RADIL--KHVIGDYK-----DIFPDLFKRAAER-----
----LQYVFGYK---------LVE-LEPKS---------NTYI-----------------
-------L----------------------------------INTLEPVEED----AEMR
----GDQGTPTTGLL-------MIVLGLIFMKGNT------IKET---EAWDFLRRL---
-----GVY-PTK----KHLIFGDPKKLITEDFVRQ------RYLEYRRI-PHTDPVDYEF
----QWGPRTNLETS--KMKVLKFVAKVHNQDPK----D-WPAQYCE---ALADEENRAR
PQPS-GPAPS--S-----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
---------------------M-------SLVSQNARR----------------------
------------------------------------------------------------
------------------CSAEIT------------------------------------
-----------------------------------------------------------A
-DY---------------------------------------------------------
-----------------------------------------------------------G
D--GRGEIQA----------------TNASGS------------P-T-------------
---------------------------------------------------SM------L
----------VVDAPQ----CPQTPINSQCV---------------NTSQ-AV-------
---------QDP----N--DLEV--LID-EQSRRLGA---LRVHDPLEDRSIALV-----
-------NFMRMKSQKEGSIQ--QSEM--LEFLREYS-----DQFPEILRRASAH-----
----LDQVFGLN---------LRV-IDPQA---------DTYN-----------------
----------------------L-------------------VSKRGF-QIT----DRIA
----ESLDMPKASLL-------ALVLGHILLNGNR------AREA---SIWDLLLKV---
-----DMW---DKPQRINNLFGNTRNLLTTDFVCM------RFLEYWPV-YRTNPLEFEF
----LWGSRAHR--EITKM-----------------------------------------
------------------------------------------------------------
--------------------------E-------------------------------AL
K-----------------------F---VS----------------DAHDEEP-------
------------------------WSWPE-EYK-------------ALEADKTKER---S
---------------------------------------------------------LT-
AG---L--------E-FWSED---TMNDKANDLVQ------LAISVT-EEMLPI--HQ--
------------------------------------------------------------
----DEL---LAHTGKEFEDVFPNILNRATLILDMFYGLSLIEVDTSEHIYL-LVQQPES
EEEQVM-LESLGR-PTQE---YVM----------PILGL----------IF--------L
-MGNR----V-K--EANVWNLLRRFSVD--VGRKHSI--------TRKLMRQH-------
---------YLECRPLSYSNP---V--EYELLWGPRAHHETTKMKVLEYMARLYRK---R
------PQNWPEQYREAVE-----------DEEARAKSEATIIFF----LDP--------
---T--------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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---------------------------------------MAQKMDCGAGLLGFQSPDA--
--CRAVCHPLPQPPASTLPLSAFPT-LCDPPYSQLRDPPPVLSCYCTPLRASLAPAEASV
EDSA-LLMQTLM-------EAIQ--IS-EAPPTNQA--TA--------------------
------------------------------------------A-----ASPQSSQPPTA-
N------------------------------------------------EMAD-------
------IQVSAAAARPKS------------------------------------------
-----------------------------AF---------------KVQ-----------
-------------NAT----------------TKGPNGVYDFSQAHNAKDVP-NTQPKAA
L-------------------KSQNATP--KGPNAAYD-------FSQAATT---------
----GELAANKSEMAFKAQNAT-TKVGPNA---------T-YNFSQSLNANDLANSRPKT
------------------------------------------------------------
----------------------------------------------PFKAWNDTTKSPTA
-------------------------------DTQT-----------QNV-----------
----NQA---KMATSQ--------ADIETD--PG---------ISESDGAAAQTSADGSQ
AQNLE--------------------S---------------------------------R
TIIRGKRTRKINNLNV---------EENSSGDQRRAPLAAGTWRSAPVPVTT-QNPPGAP
PNVLWQTPLA----WQNPS----GWQNQTARQTP----P-ARQSPPARQTPPAWQNPVAW
QNPVIWPNPVIWQNPVIWPNPI-VWPGPVVWPNPLAWQNPPGWQTPPGWQTPPGWQGPPD
WQG---PPDWPLPPDW-PLPP-DWPLP-TDWPLPPDWIPADWPIPPDWQNLRPSPNLRP-
-SPNSRASQNPGAAQ-PRDVALL---QERANKLVK------YLMLKD-YTKVPI--KR--
------------------------------------------------------------
----SEM---LRDIIREYTDVYPEIIERACFVLEKKFGIQLKEIDKEEHLYI-LISTPE-
SLAGIL-GTTKDT-PKLG---LLL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPLLGDLRKLLTYEFVKQK-------
---------YLDYRRVPNSNP---P--EYEFLWGLRSYHETSKMKVLRFIAEVQKR---D
------PRDWTAQFMEAADEALDALDAAAA--EAEAR----AEARTRMGIGDEAV-----
------SGP--WSWDDIEFELLT-WDEEGDFGDPWS-RIPF----TFWARYHQNARSRFP
QTFAG---------------------P--IIGPGGTAGA------NFAANFGAIGF----
--------FWVE------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------

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------------------------------------------------------------
----------------------------------------NY-P----------------
-----------------KVP-RHSVE-E----------------GLQA----QGE-AQG-
-------------PVGAQGARARE------------------------------------
-----------------------------------------------------------G
A-AA-----------------------APSSSTLSSCPSS--------------------
------------------------------------------------------------
--SSSFSSYSLI----LDT--TREV--FA---------------------A-G-------
----------M--------------------------------------LSPI-------
KGPQRSFS---FSTCMK-A--TASLKSDQ----------------G-SSR-REEASP---
------------S------TSEDRP------------VAKTLIREGINDKVADLV-----
-------RFLLLKYRTKELIT-KEEML--NDVIKDYR-----DHFSEIFKEASEC-----
----MNLVFGID---------VKE-VDPDG---------HSYD-----------------
-------L----------------------------------VIALGL-TYD----GMLD
---DY-QSLPKTGLL-------INVLGVIFLEGNC------AAEE---VIWEVLGVM---
-----GVQ-AGQ----EHSIYGEPRKLITHDWVQE------GYLVYRQV-PFSDPVRYEF
----LWGPRVCAETS--KMKILEFVAKVNDTVPS----A-FPVWYEE---ALRDEEARRQ
AKVEVRPSWGA-------------------------------------------------
------------------------------------------------------------
-----------------------WP--------R----------------ALC-----R-
------------------------------------------------------------
---------ATT---------------------KRPC-----------------------
------------------PK----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------

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--------------------------------------------------------TAQ-
----------------------------------------------------------GS
YS-----M-E-------SEGYNVEDMDEGSQGVG--EEEMIEGNDYE----EFGAFGGYG
TLTSFDIHI--LRAFGSLG-----------------------------AGFRILSNEPWE
LENP-VLAQTLM-------EALQ--LDPETLASEAAARAT-------------NIARPAA
---S----------NWA-TPAI--------------------AATAHITSNNR---AAAN
H------------------------------------------------PVAR-------
------DQASGDDTEPMTYAE---AQ--------------------GVTPRTTPAFPQTS
------KMPVNSEMTAPGAPAT-STEPQTAS---------------QAQ-----------
-------------EAA----------------TEGPSTASAFSQAPRASELD-TTRPKTV
FLGQ----------------------------NDVFD-------FTQPAGV---------
----SGMAFPRPKRPTPAQEA--ATDGLSA---------AS-RVHQAASAKEVAATQPKT
T-----------------------------K-----------------------------
------------------------------------------------------------
--------------------------------------------------------SGKA
LAKTRWVEPQNVVAVT--------AAEA-KMATS---------IPEPEGAAA---TVQHS
AE-----------------------P---------------------------------R
ARMGGKRTKKSKHLDDEY--------ESSE-EEREPPAVPPTWRASQPPLT---------
---------A----R---------------------------------------------
----------------------------------------TPMA----------------
-----------------PRPP-----------------------------M----T----
-LRSQIPSRHVLCLP-PRNVVLL---QERANKLVK------YLMIKD-YKKIPI--KR--
------------------------------------------------------------
----SDM---LKDVIREYDEHFPEIIERATYTLEKKFGIHLKEIDKEEHLYI-LVCTQDS
SAR-LL-GKTKDT-PRLS---LVL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLH--PGVRHPFLGDLRKLLTDDFVKQK-------
---------YLEYKKIPNSSP---P--EYEFLWGLRARHETSKMRVLRFIAQNQNR---D
------PREWKAHFLEAVDDAFKTMDVDMA--EEHAR----AQMRAQMNIGDEAL-----
------IGR--WSWDDIQVELLT-WDEDGDFGDAWA-RIPF----AFWARYHQYLLNSNR
ANRRA------TWRAGVSSGTNGGASTSILDGPSTS-ST---IRTRNAARAG--------
----ANFFSWIQ------------------------------------------------
------------------------------------------------------------
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------------------------------MPR---------------------------
----------------------GQKSK-------------------------------LR
ARE--------------------KRK-QARSEHAG---EE------------S-SSN---
-YP-------------------FYGCPHQ-TP-PGTPSFPKRPQ-G-------------A
---------QLSF----------------------LNTFLDGG-------------A---
CSKEDESSYSSENVE-DWCKDHL---NHKVVLLA-------------------I--SK--
------------------------------------------------------------
----ADM---LKSVTKSSKNDFIEILKRATDHMELAFGVDLKEVDPIKHVYA-LFNKLKH
SLEGVM-G-EERM-PNSG---LLM----------IVLGV----------IF--------T
-KNKC----V-S--ETEIWEVLNMMGVY--ANRKHFIYGDPKKVITEDLMKLK-------
---------YLEYYQVLNSNP---P--CYEFMWGSRAHAEISKM----------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
--------------------------------------MFLGQ-----------------
-----------------KSQ-PYKAE-E----------------GLQA----QGE-APG-
-------------LVDVQIPTAEE------------------------------------
-----------------------------------------------------------Q
K-A---------------------------------------------------------
------------------------------------------------------------
----ASSSSTLI----MGT--LEE------------------------------------
---------VP--------------------------------------DSGS---PSPP
QSPEGASS---SLTVTD-S--TLWSQSDE----------------GSSS--NEEEGP---
------------S------TSSDPA------------HLESLFREALDEKVAELV-----
-------RFLLRKYQIKELVT-KAEML--ESVIKNYK-----NHFPDIFSKASEC-----
----MQVIFGID---------VKE-VDPAG---------HSYI-----------------
-------L----------------------------------VTCLGL-SYD----GLLG
---DD-QSTPKTGLL-------IIVLGMILMEGSR------APEE---AIWEALSVM---
-----GLY-DGR----EHSVYWKLRKLLTQEWVQE------NYLEYRQA-PGSDPVRYEF
----LWGPRALAETS--YVKVLEHVVRINARVRI----S-YPSLHEE-----ALGEEKGV
------------------------------------------------------------
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--------------------------------------MSSEQ-----------------
-----------------KSQ-HCKPE-E----------------GVEA----QEE-ALG-
-------------LVGAQAPTTEE------------------------------------
-----------------------------------------------------------Q
E-A---------------------------------------------------------
------------------------------------------------------------
---AVSSSSPLV----PGT--LEE------------------------------------
---------VP--------------------------------------AAES---AGPP
QSPQGASA---LPTTIS-F--TCWRQPNE----------------GSSS--QEEEGP---
------------S------TSPDA---------------ESLFREALSNKVDELA-----
-------HFLLRKYRAKELVT-KAEML--ERVIKNYK-----RCFPVIFGKASES-----
----LKMIFGID---------VKE-VDPAS---------NTYT-----------------
-------L----------------------------------VTCLGL-SYD----GLLG
---NN-QIFPKTGLL-------IIVLGTIAMEGDS------ASEE---EIWEELGVM---
-----GVY-DGR----EHTVYGEPRKLLTQDWVQE------NYLEYRQV-PGSNPARYEF
----LWGPRALAETS--YVKVLEHVVRVNARVRI----A-YPSLREA---ALLEEEEGV-
------------------------------------------------------------
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----------------------LGQVSTMFSEDDFQST---EGAPSGPQI----------
---------QWSQDLPRVQVFRE----------QANQE---DRSPR-RTQRITGG-EV--
-----------------LWGPITQIFPTVWPADLTGVIMPLEQ-----------------
-----------------RSQ-HCKPE-E----------------GLQA----QED-NPG-
-------------LVGGAQALQAE------------------------------------
-----------------------------------------------------------E
Q-E---------------------------------------------------------
------------------------------------------------------------
---AASFSSTLN----VGT--LEE------------------------------------
---------VP--------------------------------------ATES---PSPP
QSPQGESS---SPAAMD-S--IFGSLSDE----------------GSSS--QEEEGP---
------------S------TSPDLI------------DPESFSQDILHDKIIDLV-----
-------HLLLRKYRVKGLIT-KAEML--GSVIKNYE-----DYFPEIFREASEC-----
----MQLLFGID---------VKE-VDPTS---------HSYV-----------------
-------L----------------------------------VTSLSL-SYD----GIRG
---DE-QSMPKSGLL-------IIVLGVIFMEGNC------VPEE---VMWEVLSIM---
-----GVY-AGR----EHFLFGEPKKLLTHDWVQE------KYLVYRQV-PGTDPACYEF
----LWGPRAHAETS--KMKVLAYIANANGRDPS----S-YPSLYED---ALREEEEGV-
------------------------------------------------------------
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------------------------------------------

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------------------------------------------------------------
--------------------------------------------------------MAE-
----------------------------------------------------------GS
FR-----M-E-------SESYNAEDMDEGSDEVR--EEEMVEGNDYE----EFGAFGGYG
TFTSFDMRL--LRAFGSLG-----------------------------PAFRILSNEPWE
LENP-TLAQTLV-------EAFQ--LDPETLANEAAAHAA-------------NVVRAAA
---S----------NRA-ARAA--------------------AAAARAAYNQV---VANH
L-------------------------------------------------LAT-------
------DQASGEDTQPTTYAATEAQG--------------------TATPETTLASPHSS
------QMPVNSEMAASGVPAT-SSQPQPAS---------------QAQ-----------
-------------EVA----------------TEGPSAACTSSQAPCASEVD-ATQPEMA
FLGR----------------------------KDVFD-------FGQPAGV---------
----SGMAFPRPKRPAPTQEA--AAEGPSA---------ASGVPQAAASSGEGAATRPKT
T-----------------------------K-----------------------------
------------------------------------------------------------
--------------------------------------------------------SGKA
LAKTRWVEPQNVVAAA--------AAKA-KMATS---------TPEQEGAAT---TAQNS
AE-----------------------P---------------------------------W
ARMGGKRTKKSKHLDDEY--------ESSE-EEREPLAVPXXXXXXXXXXXXXXXXX---
---------X----X---------------------------------------------
------------------------------------------------------------
-------------------XX-----------------------------X----X----
-XXXXXXXXXXXXXX-XXXXXXX---XXXANKLVN------YLMIKD-YKKIPI--KR--
------------------------------------------------------------
----SDM---LKDVIREYDEHFPEIIERATYTLEKKFGIHLKEIDKEEHLYI-LVCTRDS
SAR-LL-GKTKDT-PRLS---LLL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGMRHPFLGDLRKLITDDFVKQK-------
---------YLEYKKIPNSSP---S--EYEFLWGLRARHETSKMRVLRFIAQNQNR---D
------PQEWKAHFLEAVDDAFKTMDVDMA--EEHAR----AQMRAQMNIGDEAL-----
------IGR--WSWDDIQVELLS-WDEDGDFGDAWA-RIPF----AFWARYHQYILNSNR
ANRRA------TWRAGVSSGTDGGTNTIVLDGPSTS-ST---IRTRNAARTS--------
----ASFFSWIQQR----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
--------------------------------------------------------MAE-
----------------------------------------------------------GS
FS-----V-Q-------SESYSVEDMDEGSDEVG--EEEMVEGNDYE----EFGAFGGYG
TLTSFDIHI--LRAFGSLG-----------------------------PGLRILSNEPWE
LENP-VLAQTLV-------EALQ--LDPETLANETAARAA-------------NVARAAA
---S----------NRA-ARAA--------------------AAAARTAFSQV---VASH
R-------------------------------------------------VAT-------
------PQVSGEDTQPTTYAA--EAQ--------------------GPTPEPPLASPQTS
------QMLVTSKMAAPEAPAT-SAQSQTGS---------------PAQ-----------
-------------EAA----------------TEGPSSACAFSQAPCAREVD-ANRPSTA
FLGQ----------------------------NDVFD-------FTQPAGV---------
----SGMAFPRPKRPAPAQEA--ATEGPSA---------AS-GVPQTGPGREVAATRPKT
T-----------------------------K-----------------------------
------------------------------------------------------------
--------------------------------------------------------SGKA
LAKTRWVEPQNVVAAA--------AAKA-KMATS---------IPEPEGAAA--ATAQHS
AE-----------------------P---------------------------------W
ARMGGKRTKKSKHLDDEY--------ESSE-EERETPAVPPTWRASQPSLT---------
---------V----R---------------------------------------------
----------------------------------------AQLA----------------
-----------------PRPP-----------------------------M----A----
-PRSQIPSRHVLCLP-PRNVTLL---QERANKLVK------YLMIKD-YKKIPI--KR--
------------------------------------------------------------
----ADM---LKDVIREYDEHFPEIIERATYTLEKKFGIHLKEIDKEEHLYI-LVCTRDS
SAR-LL-GKTKDT-PRLS---LLL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPFLGDLRKLITDDFVKQKNPELREE
TPLSMAPSWYLEYKKIPNSNP---P--EYEFLWGLRARHETSKMRVLRFIAQNQNR---D
------PREWKAHFLEAVDDAFKTMDVDMA--EEHAR----AQMRAQMNIGDEAL-----
------IGR--WSWDDIQVELLT-WDEDGDFGDAWA-RIPF----AFWARYHQYILNSNR
ANRRA------TWRAGVSSGTNGGASTSVLDGPSTS-ST---IRTRNAARAG--------
----ASFFSWIQHR----------------------------------------------
------------------------------------------------------------
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------------------------------------------

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------------------------------------------------------------
---------------------------------------MSDT-----------------
---------------SE-SGT----------------------------GPTHFQAEASE
EDRG-LKMQTLL-------TVTQ--NLEVSEAPKAS------------------KA----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------PEVSKAMKVS-------NAAGVS---------------KTT-----------
-------------EV---------------------------SKATEAQEVS-ATQASAT
-TKLTDTQVLAA----ET--KNPAADT--KMQNTDPQ-------AVTMPAT---------
----ETKK-----VSC--------------------------------------------
------------------------------------------------------------
--------------------------------------------------------GA--
-------------------------------DTKV-------------------------
----N-T--KTLETEA--------AASQALADEP---------EP--EGAAAQAQENQDT
RPKVK--------------------A---------------------------------K
KARKVKHLNGEEDGS---------------SDQSQASGTTGGRRISKALMASMARRASRG
PIAFWARRAS----RTRLA----A------------------------------------
------------------------------------WARRALL----SLRSPKARRGKAR
RRA---------------------------------------------------------
-AKLQS-SQEPETPP-PRDVALL---QGRANDLVK------YLLVKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LKDIIKEYTDVYPEIIERAGYSLEKVFGIQLKEIDKNDHLYI-LLSTLEP
TDAGIL-GTTKDS-PKLG---LLM----------VLLSI----------IF--------M
-NGNR----S-S--EAVIWEVLRKLGLR--PGIHHSLFGDVKKLITDEFVKQK-------
---------YLDYARVPNSNP---P--EYEFFWGLRSYYETSKMKVLKFACKVQKK---D
------PKEWAAQYREAVEADMKAAAEAAA--EAKAR----AEIRARMGIGLGSE-----
----NAAGP--CNWD-------------EADIGPWA-KARIQTGAEAKAKAQESG--GAS
AG------------------AS----A--SGSFGASTSLTATLTFGLFAGLGGAGASTSG
SSGACG-FSYK-------------------------------------------------
------------------------------------------------------------
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------------------------------------------

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------------------------------------------------------------
------------------------------MPR---------------------------
----------------------GQKSK-------------------------------SR
--------------------SRAKRQ-QSRRE------VQVVQP--TAEEAGS-SPV---
----------------------DLSAGSS-FP---GGSAPQGVK-N-------------P
---------GSFG---A----------------GVSCTGSGIG---------GRNATVLP
DTKSSDGTQAGTSIQ-HTLKDPI---MRKASVLIE------FLLDKF-KMKEAV--TR--
------------------------------------------------------------
----SEM---LAVVNKKYKEQFPEILRRTSARLELVFGLELKEIDPSTHSYL-LVGKLGL
STEGSL-SSNWGL-PRTG---LLM----------SVLGV----------IF--------M
-KGNR----A-T--EQEVWQFLHGVGVY--AGKKHLIFGEPEEFI-RDVVQEN-------
---------YLEYRQVPGSDP---P--SYEFLWGPRAHAETTKMKVLKVLAKVNGT---V
------PSAFPNLYQLALRDQAGGVPRSRV-QGKGV-------------HSKAPSQKSSN
V-----------------------------------------------------------
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--------------------------------------MPRGQK---SKLRARERR-HQA
-QV-----EPQNP-----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------G-LQRATNTESIQRGHIDEKVVIMV-----
-------YYLLYKYNLKEPIR-KAEML--REVIQMYR-----SHYLEILQRAAEH-----
----MEMIFGLD---------LKE-VDPYR---------HIYI-----------------
-------L----------------------------------VNKMEV-SCD----ARLI
----NRIEIPKTGLL-------MAILGVIFMQGNC------ASEE---RVWQTLNVM---
-----GLF-NGR----KHFIFGEPKKLITKDLVQQ------KYLEYRQV-ANSDPPCYEF
----LWGLRAHAETT--KMKVLEFMAKIHNMVPT----A-FPSLYEE---ALRDEEERAQ
AR-ASAKARTA-AL----------------------------------------------
----------------------------------------------------------AK
--------------------ARS--S-----------------------AIAS-SSSHSK
RV----------------------------------------------------------
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RSVS-P-------------------------PGH----------------MLQIPR---S
R--------------------------------------------------SHPGA----
-------QLW----------------------------SSSDCCP---------------
--------GVSGE----------IPRASGHP---------------DASQ-D--------
------------------TPGAPTPNF--GQ-AQVTSAPELCTQKQLELKVAELV-----
-------QFLLIKDQRKIPIK-RSGIM--KHVVQDYK-----NIFPELLKLAAER-----
----LHYVFGYK---------LVE-LDPKS---------NAYI-----------------
-------L----------------------------------INALEPVHMD----GELR
----GCQRTPTTGLL-------MIILGLIFMNGHS------IPEN---DVWVFLRRL---
-----GVY-PTK----KHSVFGDPKKLITEDFVRQ------RYLEYRPI-PHTDPVDCEL
----QWGPRANLETS--KMKVLMFVAKIHNQDPK----H-WPTQYCE---ALMDEQRRVN
PEPQ-PQP----------------------------------------------------
------------------------------------------------------------
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------------------------------MPR---------------------------
----------------------GQKSK-------------------------------LH
ARK--------------------KRS-QARSNAQG---GENAKETATMSRAK----SRS-
--------------------------------------TPKVSQ-K------------KT
---------SASV---V-------------PAHTVL---STTS---------IDTS----
KDVTN---------E-FSHLDLM---SREVRFLEQ------FILYRF-NLKRLT--TK--
------------------------------------------------------------
----EDM---IRITSQKYKKDFEEIFRKACEHLSAVFAVEVREVS--PETYN-LVTKLKL
PNNGRV-RSGRGY-PKAG---FVM----------NVLAM----------IF--------L
-KGNC----A-T--EEEIWKFLKLMRVY--PGKKHYIFGEPKKLITQDLVRLK-------
---------YLEYRQVSNSDP---P--RYEFLWGPQAFAETSKMEVLQFLANVNET---S
------PSFFASLYEEALEEEKERG--VHP-VESKSL-----------------------
------------------------------------------------------------
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-------------------------------LQIQL-PPQQAQPS--GSQAELPAMQLQP
SWQAPPAALQAQPGAPVAGANFHRGSTKSLMTP-SGECRASSIEHRGSS-KE----RRTS
SK--ERRAPSKDRM----------IFAATFCAPKA----MSAARAHLPTTWKAFPATSET
FTATSRVF-PST----SQFQPASSNAFKSPSATSE----TLKPLPFAL---QDPYTCVEA
LPAVSWVLQPNVSASKASTAVPTILM-ATAAAPQ----T-TATT-QE---ATKT-AEQPH
RP-----------------------CKA--------------------------------
--TQK-----KKHLETEE-DNGGHVIA-------------------------------LR
--D-WQGL----RPWENLN--LSDW--EVQSPVQ-V--LGDWECPNTPCGLNGWECPSTS
-RI---------------LSG---WEGPSTSWALSAWEGPSTSQ-A--------------
---------LGLC---------------EAPGSPQPFIISEVL-------------C---
LSQGSSVMQDAATVE-TRPLYPF---NERANALVQ------FLLVKD-QAKVPI--QR--
------------------------------------------------------------
----SEM---VKVIIREYKNECLDIINCANNKLECAFGYHLKEADTKIHSYI-VINKLEC
PQGDEM-ACYLDR-PQLG---LLM----------VVLSL----------IF--------M
-KGNC----V-R--EDLIFNFLFRLGLD--VRETNGLFGNMRKLITEVFVRHK-------
---------YLEYRRIPCTEP---A--EYEFLWGPRAFLETSKMLILRFLAKLHRK---E
------PQCWPFHYLEALAECESEDADDDE-PDA----SDNG-------DDP--------
---TSSPPPS--------------------------------------------------
------------------------------------------------------------
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------------------------------------------

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--------------------------------------MSVAK-----------------
-----------------KSQ-QCKPV-E----------------GLET----AEE-APC-
-------------LVGAQA-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----AASSTLL----LGT--LWE------------------------------------
---------VP--------------------------------------TAGS---TGPP
QSPQEASA---FPTTIS-Y--TLWRQSDE----------------GCSG--QEEEGP---
------------S------TSPDP---------------ESVVRAAFTNKVAGLV-----
-------HFLLLKYKAKKPVT-KAEIL--ESVIQNYK-----RYFPVIFCKTSES-----
----LKLIFGID---------MKE-VDP TG---------HSYV-----------------
-------L----------------------------------ITCLGF-SCN----GLLG
---DN-QIFP KTGLL-------IIVLGMIAMEGDC------ASEE---EVWEELSVM---
-----EVY-DGR----EHNVYGEPWKLLTQY-------------LYRQV-PSSDPARYEF
----LWGPRALTETS--YMKVLEHVVRVSARVCI----S-YPSLHEA---ALREEEEGV-
------------------------------------------------------------
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--------------------------------------MNPTE-----------------
-----------------NSQSLFNLP-A----------------SPQA----QRE-ERG-
-------------LESAQFP----------------------------------------
------------------------------------------------------------
--------------------------------------IAEG------------------
------------------------------------------------------------
---NQVAATAST----SGE--V--------------------------------------
----------S--------------------------------------GGGT---LSSP
QSAERASS---PPAAMG-G--ES----------------------------SGR------
-------------------PLAEVA------------EPEYPSQGVLNEKIVDLV-----
-------RFLLIKFRRMELAT-KSEMM--TRAMRDYE-----EYYAVIFSKASEC-----
----MRLIFGIE---------MME-VDPFV---------HSYF-----------------
-------L----------------------------------YPALGI-TYD----GM--
LH-GV-VGVPKTGLV-------IIVLCIIFIEDNC------VSEE---VFWDVLNSL---
-----GLY-AGM----DHFIFGEPRSLITEDFVQE------GYVEYRQV-PNSCPPRYEF
----LWGPRAYAETT--KMKVLEFYASIVKQDPR----S-YPEKYAE---ALREQQERA-
------------------------------------------------------------
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--------------------------------------------------------MAE-
----------------------------------------------------------GS
YS-----V-E-------SENHSVEDMDEGSHEVR--EGGMAEGNDYE----EFGAFGGYG
TFTSFDIHI--LRAFGSLG-----------------------------PGLRILANEPWE
LENP-VLAQTLV-------EALQ--LDPETLANETAARAA-------------NVARSAA
---S----------NRA-ARAAA----------------RAAAAAARVV---------TD
H------------------------------------------------RVAT-------
------PQASGDNAQPTIYTE---AQ--------------------GATPETPLASPQIS
------QMFVTREVAVHGAPAM-STQSQTAS---------------VAQ-----------
-------------EAA----------------TEGPSTACAFSQAPRASEVD-ATGPKTA
FLGQ----------------------------NDVFD-------FTQPAGV---------
----SGMAFPRPKRPAPVQEA--ATEGPSA---------AS-GVPRAAPAREAAATRPKA
A-----------------------------K-----------------------------
------------------------------------------------------------
--------------------------------------------------------SGKA
LAKTRWVEPQNLVAAA--------AAKA-KMATS---------IPEPEGAAA---TAHHS
AE-----------------------P---------------------------------W
TRMGGKRTKKSKHLDDEY--------DSCE-EEREPPTVPQTWRASQPSVT---------
---------V----Q---------------------------------------------
----------------------------------------AQLA----------------
-----------------PRPP-----------------------------M----A----
-PRSQIPSRHVLCLP-PRNVTLL---QERANKLVK------YLMIKD-YKKIPI--KR--
------------------------------------------------------------
----SDM---LKDVIREYDEHFPEIIERATYTLEKKFGIHLKEIDKEEHLYI-LICTQDS
SAR-LL-GKTKDT-PRLS---LLL----------VILGI----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPFLGDLRKLITDEFVKQKL---REG
SSVITACSWYLEYKKIPNSSP---P--EYEFLWGLRARHETSKMRVLRFIAQNQNR---D
------PREWKAHFLEAVDDAFKTMDVDMA--EEHAR----AQMRAQMNIGDEAL-----
------IGR--WSWDDIQAELLT-WDEDGDFGDAWA-RIPF----AFWARYHQYILNSNR
ANRRA------TWRAGVSSGTNGGASTSVLDGPSTS-ST---IRTRNAARIG--------
----ASFFSWIQHR----------------------------------------------
------------------------------------------------------------
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------------------------------------------

------------------------------------------------------------
-----------------MSQQ--PSKNMGDSSPPPESPKPP-------------------
----------VYSRPTVLMRAP-----PASSRAPPVPWDPPPMDLQA-PLAAWQAPQPAW
EAPQGQLPAPLGSVCPLPQPPALGAPMVQAPPLGAPMAKPPA------------------
---------------PGVLMVHP-PPPGAPMAQPATPGVLMLHPSAPGAAMAHPPP-PVT
PMAHPP-------------------------PPGTPMGH---------------------
-----P---------P------------------PPGTPM----G-------HPPPPGTP
------------------------MGHP--PPPGTPMAHPPALGAPMVHPPPPVTPLVPP
PPPGTP--MA-------------------HVPLPGTPMAQP---PAPGVLMAQPLTPGVL
MVQPP-------------APGAPMVQPP---PPAALM-------------------TQPP
PSITPIVKPPGPGVVMIHPPSARAPIIQPQVSG---------------SPMAHPVPP---
----PGQPLASWAPQGQPFILQIQSQVI----R-------APPQV---P-----------
-------T---VPQVPQVQLATTPGWQATSHTWQGGPQGWQTTPLTWQTTQVTWQAPT--
----------ITWQAPPPI-RQGPPPIRP-------------GPPPIRPGPPPV------
-----------------------------------VRQMPHVIRQAPQVIRQAPQVIRPA
-PP---------V-----------------------------------------------
--------IRQAPPLIRPAPP-PI------------------------------------
-----------------------------------------------------------R
--------------PAPHGMASQPQLWQALPPPP-----P---------------LRQAP
QARLLAPQVQG------------VPQMPMAPPVTQ-------VVAAPPAGPQVPQP---V
L--PTPLSVP----------------------------------------MPAP------
-------QAAPQSGS-------QAVH--CPSIIWQAPKEQPPVPEE--------------
------------------------------------------------------------
------------------------------------------------------------
---------LPMSLEFQEVQQ-AQ-VM--GWQAPKVP-----THFWQPGPDQEEEEE---
----DTEVVQVE-----QQQPFRGSPASPKALQTQL-STHQAQPT--GPQAEMPAMQMEP
SWEGPPPILQAQPGASIMPTNFPRGSDRSVVTP-SRESRASSREHRGSS-KG----RRTS
AK--EKKGPPKERM----------IIGATFCAPRA----ASASRAHLPTAWKNLPATSEP
FPATSRVF-PST----SHFQPASSNAFRGPSATSE----SPRSLPFAL---QDPYACVEA
LPAVPWVQYPDVNASPACKAVPTILM-VAAAAPQ----A-AATI-PE---ASKT-TEPPR
RS-----------------------GKA--------------------------------
--TRK-----KKHLEPKE-DSCGQRMA-------------------------------TR
--D-WRAT----RPWENPS--QNDW--EIQRAVQ-L--LGDWEYLYTPQGMNAWECPSTS
-RI---------------LSG---WEGPSTSWVLSAWEHPSTSQ-A--------------
---------LGLC---------------DGSGVPQPRIFSEVP-------------S---
LSQGSIATQEDPNRE-AQPLSPL---DERANALVQ------FLLVKD-QAKVPI--QR--
------------------------------------------------------------
----SEM---VNIIIREYKGECLDIISRANTKLECAFGCQLKEIDTKTHTYI-IINKLGY
AQDSLL-VSYLKR-PMFS---LLM----------MILSF----------IF--------V
-KGYC----I-R--ENLLFSFLFRLGLD--IQETNGHFKCMKKLITNVFVRHR-------
---------YLQYRQIPSSEP---A--EYELLWGPRVFLETNKILVLRFLAKLYEK---Q
------PQISPCHYVEPQVEFECKDKDEEP-DDS----DDDS-------KEP--------
---TSSPH----------------------------------------------------
------------------------------------------------------------
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---VGT---EAQPVVKAVILYCLPSCPHSCLLPPTRVIMSQY-Q----------------
-----------------GSP-RSTHD-Q----------------HLQT----LSE-TQS-
-------------LEVSQVSKAME------------------------------------
-----------------------------------------------------------K
T-----------------------------------------------------------
------------------------------------------------------------
---ILSSSHPLV----PGN--LKEA---P---------------------AAK-------
----------T--------------------------------------VSSL-------
EGPQSSCS---SSIAIT-A--TSSGESDE----------------GSSSQ-EEEE-----
----------------------ATS------------DPENMPADALDQKVAFLV-----
-------NFILQKYQMKEPIT-KADVMKTKIIIKDDE-----SHLSEIFLRASEC-----
----LEMIFGLD---------VKK-VDPTA---------CRYG-----------------
-------L----------------------------------FIKLGL-TYD----GMLS
---GK-KGKPKTGLL-------ILVLGAIFIKGNC------ATEE---EVWEVLSLT---
-----GVY-SGK----KHFISGEPRELITKDFVKE------EYLEYQQV-ANSDPAGYEF
----PWGPRAKAETS--KMKVLEFVAKIHGTHPD----S-YPSQYEE---ALKDERARAK
I-----------------------------------------------------------
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-----------------------------QG-Q---PDIESVLKDTLDEKVADLV-----
-------DFLLLKYQSKEPIT-KAEML--MTVIRQYE-----DYFPMILKRACEC-----
----MELVFGVD---------VKE-EDPFG---------NSYV-----------------
-------F----------------------------------HNTLDL-TCD--------
-----YQGMPKTGLL-------VLILGMIFMEGNC------VTEE---KIWEMLNST---
-----GVY-AGT----EHVIYGEPSQFITRDLVKE------KYLEYRQV-PNSDPPRFEF
----LWGPRAHAETS--KMKVLEFLAKVNGSIPS----A-FPSWYED---ALRDEEERAK
VGAL-GNCSSF-LDSHVF------------------------------------------
------------------------------------------------------------
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--------------------------------------MPLEQ-----------------
-----------------RSQ-HCKPE-E----------------GLEA----RGE-ALG-
-------------LVGAQVPVTEE------------------------------------
-----------------------------------------------------------Q
E-S---------------------------------------------------------
------------------------------------------------------------
----ASSSSTLV----EVT--LGE------------------------------------
---------VS--------------------------------------AAD------PQ
----GAST---LPTIIN-C--TLWSQSDE----------------GSSN--QEEEGP---
------------S------TFPDL---------------ETGFQAALSRKVAELV-----
-------HFLLLKYRAREQFT-MAEIL--E-----------SYFFPVIFSKASEY-----
----VQLVFGIE---------VME-VVPIS---------HLYI-----------------
-------L----------------------------------VTCLGL-SYN----GLLG
---EN-QIMPTTDLL-------IIILATVAIEGDG------APEE---KVWEELSVL---
-----ELS-GRR----EDSVLANPSKLLTQVLVQE------NYLEYRQV-PFSDHACYEF
----LWGPRALVETN--YVKVLYHMLKITGEPRI----S-YPPLHEW---AWREGKE---
------------------------------------------------------------
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--------------------------------------MPRSQK---SKLRYREKC-RQA
-RE-----ESQGP-----------------------------------------------
-HG-------------AQASVEVK------------------------------------
-----------------------------------------------------------E
-EAP-------------------------SSPSA-----V---------------SGGSP
QSSP-A-------------------------AGH----------------PEEPPR---S
L--SPLTLAAAV--S--GPRAEEEA----ERP------------SSP-EAPGSPQ-SPGS
PEAPGSPQS--PG---------------------------VPQSPGS----PE-----AL
GSPEAPGSPEAPGSPEATG----FPEAPGSP---------------EG-L-SSPEALGSP
EALGYPQSQGSP-----------------EG-PSTWGATRHSRRDPLSRKAALVL-----
-------QFLLNKYKLKQPIL-KADML--KLIRRKYK-----EQFPEILRMCSER-----
----LELVFGLD---------LKE-HDASA---------QSYL-----------------
-------L----------------------------------VSKLDP--SE----TNLS
----GGWGLPRNGLL-------LPLLGVIFLNGNC------APEE---EIWQFLSLL---
-----GVY-KGR----RHFIFGDPWKLITRDLVRE------KYVEYRQV-AQSSPPRYEF
----LWGPRAHAVTS--KMKVLEFLAKVNDTVPS----A-FHSHYEE---ALKDEEERAQ
ARAA--------------------------------------------------------
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------------------------------------------------------------
--------------------------------------MPRGQK---SKLRAREKR-RET
-HG-----QPQDL-----------------------------------------------
-TG-------------PQVTAEKE------------------------------------
-----------------------------------------------------------E
-ESR-----------------------SSSSSSA-----V---------------CRGAR
RRSS----------------------------DSS-------V-------PQESQG---A
S--PTDSPDAGASCSKSDVAA----KGKDEKS------------PSASRDASVSQESQ-G
ASPIGSPDAGISC---------SKS--------DVAAKGQDEKIPSTSPDASL-----PQ
ESQGASPTG---SPDADVS----GSKSDVAA---------------KGQ---EEESI---
-----------------------------SP-SLRTAFFTTTDRDPLNRKANKMV-----
-------QFLQKKFEKKESIL-KADML--RHVRRQHK-----PCFPEILKRTSER-----
----LVVVFGVE---------LKE-MDSSG---------ESYT-----------------
-------L----------------------------------VSKLGL-SSE----GSLS
----GDNALPKSGVL-------MALLSLIFIKGNR------ATEQ---EVWEFLGGW---
-----AIC-DGI----LHSIYGDVRKIITEDLVQD------KYVVYRQV-RNSDPPRYEF
----LWGPRAHAETT--KMRVLRVLAEINKTSPG----L-YPHLYED---ALIDEVERAL
RLRV--------------------------------------------------------
------------------------------------------------------------
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--------------------------------------MPRGQK---SKLRAREKR-RQN
-RA-----EAQGL-----------------------------------------------
-KS-------------AQAATAEE------------------------------------
-----------------------------------------------------------E
-AT--------------------------ASSPP-----V---------------TGDGA
SSSS-V-------------------------AGS----------------LQAPAR---V
S--AA-ASAAAG------------------------------------------------
------------------------------------------------------------
-----------------VS----CRRSDVRA---------------KS-R-VQ-KSE---
-----------------------------NS--QAAPSSESSGHDLLTRKAGMLM-----
-------HFLLCKYKMNEPIK-KGDML--KVIHKRYR-----EHFPEILKKASER-----
----MDLVFGLE---------LKE-VKPNG---------HSYS-----------------
-------L----------------------------------VCKLDD-SRD---EST-S
----NALRFPTKVIL-------MPLLGLIFLNGNR------ASEE---EIWELLNIL---
-----GVY-DEE----THCILGEPRDIITQNLVQE------KYLEYRQV-PGSDPPRFEF
----LWGPRAQAETT--KGKVLDFLCKVNDTFPT----D-FPPHYEE---LLRDEKERAR
------------------------------------------------------------
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--------------------------------------MPRGRK---SKLRTRERR-CQA
-QS-----GTQGL-----------------------------------------------
-TG-------------AQATAAEE------------------------------------
-----------------------------------------------------------E
-AA--------------------------SSSCP-----S---------------LGVTT
RRKP-G------------------------AKSRS-------T-------LKSPQR---A
L--ATTTNPA-G------------------------------------------------
------------------------------------------------------------
-----------------VS----PARSNKGA---------------KG-Q-MK-KKH---
-----------------------------SS-SQAPVSAVRSRKGPLRRTASVLV-----
-------QFLVHMYKMKKPVR-KAHML--KFIAKKYQ-----NRFPEILRRASFS-----
----MEMLFGVD---------LKE-VDRTK---------HTYT-----------------
-------F----------------------------------VSKMAL-PND----GTMS
----RGSGLPKTGLL-------MYILAVILMKGNC------ATEE---NIWEFLNKM---
-----RVY-AGK----RHFIFGEPKKLITQDWVKL------KYLEYRQV-ANSDPARYEF
----LWGPRAHAETS--KMKVLEFLAKVNHTVPS----A-FQSWYEE---ALKDEEERAQ
------------------------------------------------------------
----------------------------------------------------------AS
--------------------GCSSVL-----------------------SSS---SHT--
------------------------------------------------------------
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------------------------------------------------------------
------------------MSQ--LSKNLGDPSPPEEAPKPA-------------------
----------VYSRPTVLMRAP-----PASSRAPPVPWDPPPIDLQA-SLAAWQAPQPAW
EAPQGQPPAPI---APMSQPPSLGGPMVQAPPLGGPMGKPPT------------------
---------------PGVLMIHP-PPPGAPLAQPPTPGVLMMHPSAPGAPMAHPPP-PGT
PMAHPP-------------------------PPGTPMAH---------------------
-----P---------P------------------PPG---------------------TP
------------------------MVHP--PPPGTPMTHPPPPGTPMAHPP---------
PPPATP--MA-------------------HPPPPGTPMAQP---PAPGVLIPQPLTPGVL
MVQPP-------------APGAPIAQPP---PPAPLM-------------------AQPP
PLGAPMAKPPGPGVLMIHPAGSRPPITQPPATG---------------APIVQPPAP---
--APPAQPMASWAPQAQPLILQIQSQVI----R-------APPPV---P-----------
-------Q---GPQAPPAPLATPPGWQATSPGWQAPPQGWPATPLGWSTTQVTWPGPT--
----------IAWQAPLSV-RPGPPPIRP-------------GPPPIRPGPPPIR---QA
PPP---------------------------------------------------------
------------------------------------------------------------
--------IRQAPPLIRQAPP-PI------------------------------------
-----------------------------------------------------------R
--------------PAPQVLATPPPLWQSLPPPP-----P---------------LRQAP
QTRLPTPQLRAA------PPIRAAPQVPTAPPAPQ-------MPTAPPAVPQAPPT---V
M--PAPLPVP----------------------------------------LSA-------
----------P-----------QAVH--CPPIIWQAPKGQPPVPQE--------------
------------------------------------------------------------
------------------------------------------------------------
---------MPTSMEFQEVQQ-AQASL--AWQAPKAQ-----GQFWQSLPTQEAQRQ---
----GPPLVQLE-------QPFQGAPASQKALQIQL-PTQQAQLS--GSQAELPSMQLQP
SWQGPSAALQGQPGAPLTGANFPMGSAKSLMTS-SGESRASSMDRRTSS-KD----RRTS
SK--ERKAPLKDRM----------IFGGTFCAPRA----MPTAGAHLPTPWKNLPTTSET
FNATPRVF-PST----SQFQPASSNAFKGPSATSE----APKSLPFTL---QDPFACIEA
LPAIPWVPQPNVNSSKASKAGPSILM-ATAAAPQ----V-MAIT-QE---ASKTSAEPPR
RS-----------------------GKA--------------------------------
--TRK-----KKHLNTEEEDSSGKMLN-------------------------------MC
--H-WQAP----RRWESLD--LNDW--EVQTPIQ-F--LCDWEGPSTSRILSGWEGLSTS
-QI---------------LSG---WEGPSTSWALSAWEGPSTSR-A--------------
---------LGLW---------------ESPVSPPSLIISELP-------------T---
LAQGCGATQYDPKLE-TQPLSPL---DERANALVQ------FLLVKD-QAKVPI--KR--
------------------------------------------------------------
----SEM---VKFIIREYKDECLEIISRASHKLECVFGYQLKEIDPQNHSYI-LINKG--
RKGDTG-VSYLDR-PKLG---LLM----------VVLSL----------IF--------M
-KGNC----V-R--EDLIFTFLCKLGLN--IRETHGLFGNTKKLITEVFVREK-------
---------YLEYRRIPFTEP---E--EHEFLWGPRAFLETSKMIVLKFLARLYKK---D
------PRCWPYQYYEALAECESEDLDEDE-SGP----DDKT-------DDP--------
---TSSPPPH--------------------------------------------------
------------------------------------------------------------
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------------------------------MPR---------------------------
----------------------GQKSK-------------------------------QN
NRG--------------------RRR-RARNDTQA---SESAQQTIEAAEESF-PESGG-
--------------------------------------AFEMPD-E------------ES
---------VAII---I-------------ADVLSLIVSDESS---------IDDQ----
DVEESLFRN--YHAF-TIHQDIL---AGKVAVLLQ------FLLDNY-KMKQLT--SM--
------------------------------------------------------------
----KDM---MQVIGEQEINNFPEILRTTAERLEDIFAVELREVESSRPAYD-LISKLKL
PNNGRV-RAGKGF-PKTG---FLM----------TVLGM----------IF--------M
-NGNC----A-R--EGDIWRMLRSMGVY--PGKKHPIYGEPRKLITQDFVKLK-------
---------YLEYQQVANSDP---P--LYEFQWGPKAYAETNKMTVLKFVAKINKV---S
------PSSFRDLYEEALKTEQGKNPNNHK-VSRDTPAKA-SAFS----MMTGPWFPILP
KFENGLFS----------------------------------------------------
------------------------------------------------------------
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--------------------------------------MPRGQK---SKVRAREER-RRN
-RD-----ETQGL-----------------------------------------------
-NA--------------QATTAGV------------------------------------
-----------------------------------------------------------E
-ETT-------------------------SSPVS-----V---------------SQGTP
PSSA-A-------------------------AGT----------------CQEPQG---A
P--AT-SSRDAG------------------------------------------------
------------------------------------------------------------
-----------------VS----CPGYDVHA---------------KG-Q-VE-ESK---
-----------------------------NS-SQASTSRD-PGKDLVTRKAGMLV-----
-------QFMLYKYKIKEPIK-KGEKL--KIVNKRYR-----EHFPEIPRRASEC-----
----MELVFGLE---------LKE-VKPNS---------HSYA-----------------
-------L----------------------------------VGKLDL-TDD---GRR-S
----SGGRFRKNGPL-------MPVLGVI-LHGDR------ASEE---EIWESLNVL---
-----GVF-DGR----RHFILVEPRKVITEDLVQE------RCLEYRQV-PSSNPPCSEF
----LWGLRARAETS--KMKVLEVLAKIHNTVPT----A-FPPHNEE---ALRDEGERAR
------------------------------------------------------------
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--------------------------------------MSLEQ-----------------
-----------------RSL-HCKPE-E----------------ALEA----QQE-ALG-
-------------LVCVQA-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---ATSSSSPLV----LGT--LEE------------------------------------
---------VP--------------------------------------TAGS---TDPP
QSPQGASA---FPTTIN-F--TRQRQPSE----------------GSSS--REEEGP---
------------S------TSCIL---------------ESLFRAVITKKVADLV-----
-------GFLLLKYRAREPVT-KAEML--ESVIKNYK-----HCFPEIFGKASES-----
----LQLVFGID---------VKE-ADPTG---------HSYV-----------------
-------L----------------------------------VTCLGL-SYD----GLLG
---DN-QIMPKTGFL-------IIVLVMIAMEGGH------APEE---EIWEELSVM---
-----EVY-DGR----EHSAYGEPRKLLTQDLVQE------KYLEYRQV-PDSDPARYEF
----LWGPRALAETS--YVKVLEYVIKVSARVRF----F-FPSLREA---ALREEEEGV-
------------------------------------------------------------
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--------------------------------------MPRGQK---SKHCACEKR-RQA
-RA-----ETQGL-----------------------------------------------
-HD--------------QATTSGG------------------------------------
-----------------------------------------------------------E
-ETT-------------------------SSSPP-----D---------------SESGP
SSSS-A-------------------------AGT----------------SKGPQG---A
Q--GTTSAAAGAVRKRSGVGRA--------------------------------------
------------------------------------------------------------
--------ARSRS--------------GVGA---------------EG-Q-VQEGE----
-----------------------------NS-SQASAAAESSHTDLLTRKAGVLV-----
-------QYMLYKYQVRERIK-RSEML--KAITRRYR-----EQFPEILSRASER-----
----MEMVFGLV---------LKE-VRPNS---------HCYT-----------------
-------L----------------------------------VSNLDL-SDS----ESMR
----GNWGLPKNGLL-------MPLLGVIYLNGHR------ASEE---EIWKFLNIL---
-----GIY-DGR----SHFIFGEPRKLITEDLVRE------GYLEYRQV-PGSDPPRYEF
----LWGPKALTETS--KTKVLQFLTKVNDLVPN----A-LLPYYEE---AWREEIETSA
RADM------SVSARA--ARAG---PVASARPG---------------------------
-----------------------TSA----------------------------------
-E--------------------TRAGTSSLARPDM-----FA---------SASADPSAL
ARD-----------------G-TS---------------------A-----AARADMSAL
---------ASAGPSPSARAG-TSASANAHSRAASSCS----------------------
------------------TRP---------------------------------------
------------------------------------------------------------
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---------------------------------------------------QDEER----
-----------------PSTGLDPA------------DAKSSHPDPFHLKAADLV-----
-------GFLLLKYRTKEPTT-KEDML--NAVLRADQ-----DHFPVVLSQASEC-----
----LQLVFGVD---------VKK-VDPRE---------HLYV-----------------
-------L----------------------------------VPTLGL-TSD----GMLG
---G-GQSLPKNGLL-------VMLLGVILLEGEC------ATEE---KMWEALSVM---
-----GVY-PGR----EHFIYGEPRELITKAWVQE------GYLEYRQV-ANSDPARHEF
----LWGPRAHAETS--KLQVLEHFLRVNTRNLC----S-FLSLSEE---VLSNEENWP-
------------------------------------------------------------
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--------------------------------------------------------MAE-
----------------------------------------------------------GS
YS-----M-E-------SESFTVEDMDEGSDEVG--EEEMVEGNDYE----EFGAFGGYG
TLTSFDIRV--LRAFGSLG-----------------------------PGLRILSNEPWE
LENP-VLAQTLV-------DALQ--LDPETLANETATRAA-------------NIARAAA
---S----------NRA-ARAA--------------------AAAARTASNDQ---VAFN
Q------------------------------------------------PVDT-------
------DQASGEDTQPMIYTK---SQ--------------------GATPETTPASSQIS
------QMQINSDMAAPGAPAT-PTQPQTAS---------------QAQ-----------
-------------EAA----------------TEGPSTTRTSSQALYASELD-ATQPKTA
FPGH----------------------------NDVFD-------FTQPAGV---------
----SGMAFTRPKRPAMAQEA--ATEGPSA---------AS-GVPQAASAREVAATQPKT
N-----------------------------K-----------------------------
------------------------------------------------------------
--------------------------------------------------------SGKA
LAKTRWVEPQNVVTAA--------AAKA-KMATG---------IPEPEGAAA---TIQHS
AE-----------------------P---------------------------------W
ARMGGKRTKKSKHLDDEY--------ESSE-EEREPPTVPPTWRASQPPLM---------
---------A----R---------------------------------------------
----------------------------------------SQVA----------------
-----------------PRPP-----------------------------M----A----
-LTSQIPSRHVLCLP-PRNVTLL---QERANKLVK------YLMIKD-YKKIPI--KC--
------------------------------------------------------------
----SDM---LKDVIREYDEHFPEIIERATYTLEKKFGIHLKEIDKEEHLYI-LVCTRDS
SAR-LL-GKTKDT-PRLS---LLL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLH--PGVRHPFLGDLRKLITDDFVKQK-------
---------YLEYKKIPNSSP---P--EYEFLWGLRARHETSKMRVLRFIAQNQKR---D
------PREWKAHFLEAVDDTFKTMDVDMA--EEHAR----AQMRAQMNIGDEAL-----
------VGR--WSWDDIQVELLT-WDEDGDFGDAWA-RIPF----AFWARYHQYILNSNR
ANRRA------TWRAGVSSGTNGGVSTSILDGPSTS-ST---IRTRNAARAG--------
----ANFFSWIQHR----------------------------------------------
------------------------------------------------------------
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--------------FLEPVC-PCKLE-E----------------DFEM----FRE-AQG-
-------------PQGWQPPLDEH------------------------------------
-----------------------------------------------------------Q
EAEHLSSSS------AS-------------------------------------------
------------------------------------------------------------
-----------------MR--QEEG-----------------------------------
---------AE----------------------------------------------S--
---------------------STRSLGEQ----------------G--------------
---------------------VAPP-----------QEEAPRPQEVPSRLVATVV-----
-------AFLLQKYRSREPTT-KAEIL--SRLFPGQQ-----QLFPTVFAKACEC-----
----MQVVFGIE---------VRE-ADPQA---------QSYD-----------------
-------L----------------------------------AIALGL-SYD----GMLG
-P--E-QSVPKTGLL-------LMVLGLILLHGDC------APEE---AVWEALAMM---
-----GIY-ACG----DHFLFGDPWELLTQEWVLE------QYLVYQHV-PGSWPAHYHF
----HWGPRAHHEVC--KLRLLL-WLKVSSTEPT----S-FLYPYEL---REE-------
------------------------------------------------------------
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--------------------------------------MP--------------------
---------LFPNLS------HLSFE-Q----------------DFQN----PTV-IED-
-------------L----------------------------------------------
-------------------------------------------------VDVQDS--IDE
EEEDAS----------------------ST--SSFHFLLPSSSSSSS----------S--
------------------------------------------------------------
------SLCTLF----LSA--SEDEEMP----------------LI----PPHCPP---E
I-PQGVPQSPP--------------------------------------QSHL---QNPP
QSSLNSCS--------S-P--FLWTPLEE----------------ESSSE-EEEE-T---
------------P------LWQAF------------PDSQSLSRYVLDEKVAELV-----
-------QFFLLKYQKKEPVT-KAEML--TTVTKKYK-----DYFPLIFGKAHEF-----
----IELIFGIS---------LTD-VDPDN---------HCYF-----------------
-------F----------------------------------EDTLDL-TCE----GS--
LI-DD-LGMPQNCLL-------ILILSMIFIKGSC------VPEE---VIWEVLSAI---
-----GVY-PGR----EHFIYGEPRELLTKDWVQR------KYLEYREV-PNSAPPQYEF
----LWGPKAHSEKS--PRVFVQVIHYHP-------------------------------
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--------------------------------------MPHS-P----------------
-----------------KRP-RLTFE-P----------------GFQT----LSE-IES-
-------------LLVTQIPTAE-------------------------------------
-----------------------------------------------------------E
E-DT-----------------------TSISSCSFTF--SYPST----------------
------------------------------------------------------------
----SPPSSPLI----PGM--LEEKQEQE---------------------EQEQQE---E
QEPEQEPATVM--------------------------------------LGPP-------
QSPQ---N---SSSTSWST-------SDG----------------G-WSS-QEEKDT---
------------Y------FVQASA------------GTESLPRDLLDGKVADLV-----
-------HFMILKYRLKEPIT-KAEML--KVVIKRYK-----SQFPMIFKKASKC-----
----LEVISGID---------VKE-VDPQI---------HSYV-----------------
-------L----------------------------------VNSLDL-THD----EMLS
---DD-QSMPKNGLL-------IIILGVIFIEGNC------APEE---SIWDFLNII---
-----GVY-AGR----EHFIYGEPRKLITRDWVQE------NYLEYRKV-PNSDPPLYEF
----LWGKRAHAETS--KVKVMEFLAKIKGTDPI----S-FSFWYEV---ALRDEEERTG
AINGHVDSNTG-------------------------------------------------
------------------------------------------------------------
-----------------------MF--------I----------------VVSH---GS-
------------------------------------------------------------
---------FDL---------------------HFSY-----------------------
--------------------NQ------RC------------------------------
------------------------------------------------------------
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--------------------------------------------------------MAE-
----------------------------------------------------------GS
YS-----V-Q-------SGPSSVEDMDEGSHQVR--EEEMVGGNAFE----EFGAFGGYG
TLTTFDIHL--LRAFDTLG-----------------------------SGFRILSAP---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------SASETD-ATRPRAA
FLGQ----------------------------NDVFD-------FTQPAGV---------
----SGMAFMRPKRPAPAQEP--ATGAS-S---------AASGVPQAVSAKEAAATRPKA
T-----------------------------K-----------------------------
------------------------------------------------------------
--------------------------------------------------------SGKA
AAKTRWVEPPNAVATA--------AANT-KMATS---------IPEPEGPAA---TAQHS
GE-----------------------P---------------------------------W
ARMGGKRTKKSKHLDDEY--------ESSE-EEREPPAVPATWRALQQPPVS--------
---------A----Q---------------------------------------------
----------------------------------------AQVA----------------
-----------------PRPP-----------------------------M----A----
-PRSQIPSRHVLCLP-PRNVTLL---QERANKLVK------YLMIKD-YKKIPI--KR--
------------------------------------------------------------
----SDM---VKDVIREYDEHFPEIIERATYTLEKKFGIHLKEIDKEEHLYI-LVCTRDS
SAR-LL-GKTKDT-PRLS---LLL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWDALRKMGLR--PGVRHPFLGDLRKLITDDFVKQK-------
---------YLEYKKIPSSNP---P--EYEFLWGLRACHETSKMRVLRFIAQNQNR---D
------PREWKAHFLEAVDDAFRTMDMDMA--EEHAR----AQMRAQMNIGDEAL-----
------IGR--WSWDDIQAELLT-WDEDGDFGDAWA-RIPF----AFWARYHQYILNSSR
ANRRA------TWRAGVSSGPNPGASTSILDGPSTS-ST---IRTRNAARAG--------
----ASFFSWIQQR----------------------------------------------
------------------------------------------------------------
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--------------------------------------MPRGQK---SKLRAREKR-RQA
-RE-----ETQGV-----------------------------------------------
-KG-------------AQATVAAE------------------------------------
-----------------------------------------------------------E
-EPT-------------------------SSSSD-----C---------------CKDPT
QSSS-A------------------------AETPS-------T-------PQGPPS---A
L--PPTTSEA-A------------------------------------------------
------------------------------------------------------------
-----------------VS----CTRANEGA---------------NY-Q-GN-ESP---
-----------------------------SS-AQAEPTTEHSQE-GLDKKVVILV-----
-------HYLLYKYQVREPVT-KADML--RNIMQIYK-----NQFPEILRRASEH-----
----LELVFGLD---------LKE-VDPIR---------HTYV-----------------
-------L----------------------------------VNKLDS-SSS----GRIS
----DDVGVPTTGLL-------MTVLGVIFTKGNC------ATEE---EVWEVLNTM---
-----GLH-AGR----DHFIFGEPKKLITRDMVKQ------KYLEYRQV-PNTDPPRYEF
----LWGPRAYAETT--KMKVLEFVAKVHDTTPS----A-FPSCLEE---AIKDEEERAQ
AR-VESRARSS-AM----------------------------------------------
----------------------------------------------------------SG
--------------------THS--R-----------------------ATPS-SSSCP-
------------------------------------------------------------
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-----------------------------------------------------MSEQSKD
VCD---------------------------------------------------------
------------------------------------------------------------
--------PDS----------------------------A---------------PQA-S
NSEV--------------------------HIS-----------------PGVPGG---P
S--QPASQAAT----------LAAPESPPLGP------------I---------------
----EAPLPS--------------------------------------------------
------PPP--------------QAPSEEGD---------PKAL-QQA-A-EE--GR---
----------------------RPSXX-------XXX-XXPPAPAQLVQKAHELM-----
-------WYVLVKDQKRMIIW-FPDMV--KDVIGSYK-----KWCRSILRRTSLI-----
----LARVFGLH---------LRL-TSLHT---------MEFS-----------------
-------L----------------------------------VKALEPEELD-----RVA
----LSNRMPMTGLL-------LMILSLIYVKGRG------ARES---AVWNVLRIL---
-----GLR-PWK----KHSTFGDVRKLITEEFVQQ------NYLKYQRV-PHVEPPEYEF
----FWGSRASREIT--KMQIMEFLARVFKKDPQ----A-WPSRYRE---ALEEARALRE
ADPTA----------------------------------HCPRSSVSED-----------
------------------------------------------------------------
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-----------------------------------------------------MSEQSKD
LSD---------------------------------------------------------
------------------------------------------------------------
--------PNF----------------------------A---------------AEA-P
NSEV--------------------------HSS-----------------PGVPEG---V
P--PS-----AT---------LAEPQSPPLGP------------T---------------
----AAPQAA--------------------------------------------------
------PPP--------------QAPNDEGD---------PKAL-QQA-A-EE--GR---
----------------------AHQAP----SAAQPG-PAPPAPAQLVQKAHELM-----
-------WYVLVKDQKKMIIW-FPDMV--KDVIGSYK-----KWCRSILRRTSLI-----
----LARVFGLH---------LRL-TSLHT---------MEFA-----------------
-------L----------------------------------VKALEPEELD-----RVA
----LSNRMPMTGLL-------LMILSLIYVKGRG------ARES---AVWNVLRIL---
-----GLR-PWK----KHSTFGDVRKLITEEFVQM------NYLKYQRV-PYVEPPEYEF
----FWGSRASREIT--KMQIMEFLARVFKKDPQ----A-WPSRYRE---ALEEARALRE
ANPTA----------------------------------HYPRSSVSED-----------
------------------------------------------------------------
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-----------------------------------------------------MSEQSKA
LGD---------------------------------------------------------
------------------------------------------------------------
--------PSF----------------------------A---------------AEA-P
DSEA--------------------------CDS-----------------PGVPMG---A
P--PPTPQAAT----------LAGPENPAPGQ------------T---------------
----DVPQAP--------------------------------------------------
------PQP--------------QPTSEKGD---------AKAL-QQA-A-EE--GC---
----------------------ARQAL--NAAQAQPG-PAPPAPAQLVQKAHELM-----
-------WYVLVKDQKKMIIW-FPDMV--KDVIGSYK-----KWCRSILRRTSLI-----
----LARVFGLH---------LRL-TSLHT---------MEFS-----------------
-------L----------------------------------VKALEPEELD-----RVA
----LSNHMPMTGLL-------LMILSLIYVKGRG------ARES---AVWNVLRIL---
-----GLR-PWK----KHSTFGDVRKLITEEFVQQ------NYLKYQRV-PYLEPPEYEF
----FWGSRASREIT--KMQIMEFLARVFKKDPQ----A-WPSRYRE---ALEEARALRE
AEAAA----------------------------------HFPRSSVSED-----------
------------------------------------------------------------
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--------------------------------------MPLR-Q----------------
-----------------QNE-LRKME-N----------------ELED----PIE-DHS-
-------------LVEAQLHWGEE------------------------------------
-----------------------------------------------------------E
------------------------------------------------------------
------------------------------------------------------------
-------PTLPS----SSS--SSVS---S---------------------SYS-------
----------T--------------------------------------PSPP-------
QDPQGVCP---SPAP-VAP--TPLSQSKD----------------DASGS-QDDEGP---
------------S------PSHDQE------------HADASQSGSLHLKVADLV-----
-------EFLLLKYCAKEPTT-QAEML--SVVLRDAQ-----DHFPEVLSQASEL-----
----IQLVFGLD---------VKE-VDPSE---------HTYV-----------------
-------L----------------------------------VPTLGL-TWD----GVLS
---DG-QSLPKTGLL-------VVLLGVILLQGEC------APEE---EVWAALDRM---
-----GVC-AGK----EHCIYGEPRELLTQVWVQE------GYLEYHQV-PHSDPARYEF
----LWGPRAHAETS--KLQVLERMFTVSEKDPR----S-CPSLSEE---AMIEEEEGS-
------------------------------------------------------------
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--------------------------------------MPRGHK---SKLRAREKR-Q--
--------EPQGL-----------------------------------------------
-TS-------------PQATAEKQ------------------------------------
-----------------------------------------------------------E
-ESH-----------------------SSSSSSC-----A---------------CLGDC
RRSS----------------------------DAS-------V-------PQESQG---V
S--PTGSPDAVVSYSKSDVAA----NGQDEKS------------PSTSRDASIPQESQ-G
ASPTGSPDAGV-------------------------------------------------
------------------S----GSKYDVAA---------------KGQ---DKESL---
-----------------------------SS-SQKAIIFKRLSRDPVKTKACTLV-----
-------QFLQEKFEKKESIL-KADML--KRVRREYK-----PYFPEILNRTSEH-----
----LAVAFGVE---------LKE-MDSSG---------ESYT-----------------
-------L----------------------------------VSKLGL-SSE----GILS
----GDKGLRKSGLL-------MSLLVVIFMNGNR------ATEE---AVWEFLGVL---
-----GVY-DGI----LHSIYGDARKIITEDLVQD------KYLLYRQV-CNSDPPCYEF
----LWGPRAYAETT--KMRVLRVLAESSNTSPG----S-YPHLYED---ALIDEVERAL
RLRD--------------------------------------------------------
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--------------------------------------MPRGQK---SKLRARGKR-RET
-HD-----QPQGL-----------------------------------------------
-TG-------------PQATAEKQ------------------------------------
-----------------------------------------------------------E
-ESR-----------------------SSSSSSA-----V---------------CRGAR
RRSS----------------------------GSS-------V-------PQESQG---A
S--PTGYPDAGASCSKYDVAA----MGQDEKS------------SRTSRDASVPQESQ-G
ASPTGSPDTGVSG---------SKY--------DVAANGQDEKSPSTSHDVSV-----PQ
ESQGASPTG---SPDAGVS----GSKYEVAA---------------ESE---DEESV---
-----------------------------SA-SQKAIIFKRLSKDAVKKKACTLV-----
-------QFLQKKFEKKESIL-KADML--KRLRGEYK-----PHFPQILNRTSEH-----
----LAVAFGVE---------LKE-MDSSG---------ESYT-----------------
-------L----------------------------------VSKLGL-PSE----GILS
----GDKGLQKSGLL-------MSLLVVIFMNGNR------ATEE---EVWEFLGLL---
-----GIY-DGI----LHSIYGDARKIITEDLVQD------KYVVYRQV-CNGDPPCYEF
----LWGPRAYAETT--KMRVLRVLAEINNTSPG----F-YPHLYED---ALTDEVERAL
RLRA--------------------------------------------------------
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--------------------------------------------------------MAE-
----------------------------------------------------------GS
FS-----V-Q-------SENYSVEDMDEGSDEVG--EEEMVEGNDYE----EFGAFGGYG
TLTSFDIHI--LRAFGSLG-----------------------------PGLRILSNEPWE
LENP-VLAQTLV-------EALQ--LDPETLANETAARAA-------------NVARAAA
---S----------NRA-ARAA--------------------AAAARTAFSQV---VASH
R-------------------------------------------------VAT-------
------PQVSGEDTQPTTYAA--EAQ--------------------GPTPEPPLASPQTS
------QMLVTSKMAAPEAPAT-SAQSQTGS---------------PAQ-----------
-------------EAA----------------TEGPSSACAFSQAPCAREVD-ANRPSTA
FLGQ----------------------------NDVFD-------FTQPAGV---------
----SGMAFPRPKRPAPAQEA--ATEGPSA---------AS-GVPQTGPGREVAATRPKT
T-----------------------------K-----------------------------
------------------------------------------------------------
--------------------------------------------------------SGKA
LAKTRWVEPQNVVAAA--------AAKA-KMATS---------IPEPEGAAA--ATAQHS
AE-----------------------P---------------------------------W
ARMGGKRTKKSKHLDDEY--------ESSE-EERETPAVPPTWRASQPSLT---------
---------V----R---------------------------------------------
----------------------------------------AQLA----------------
-----------------PRPP-----------------------------M----G----
-PRSQIPSRHVLCLP-PRNVTLL---QERANKLVK------YLMIKD-YKKIPI--KR--
------------------------------------------------------------
----ADM---LKDVIREYDEHFPEIIERATYTLEKKFGIHLKEIDKEEHLYI-LVCTRDS
SAR-LL-GKTKDT-PRLS---LLL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPFLGDLRKLITDDFVKQKNPELREE
TPLSMAPSWYLEYKKIPNSNP---P--EYEFLWGLRARHETSKMRVLRFIAQNQNR---D
------PREWKAHFLEAVDDAFKTMDVDMA--EEHAR----AQMRAQMNIGDEAL-----
------IGR--WSWDDIQVELLT-WDEDGDFGDAWA-RIPF----AFWARYHQYILNSNR
ANRRA------TWRAGVSSGTNGGASTSVLDGPSTS-ST---IRTRNAARAG--------
----ASFFSWIQHR----------------------------------------------
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--------------------------------------------------MLSKPR---G
R--------------------------------------------------GRPSP----
-------HTD----------------------------RDRGGGGR--------------
----------GDE----------TPSTSRGP---------------GSAQ-E--------
------------------TPGSSWS-----L-SASAPAPGARTQKQLELKVAELV-----
-------QFLLIKDQKKIPIK-RTDIL--KHVIGDYR-----DIYPNLLKLAAER-----
----LQYVFGYE---------LVE-LEPKS---------NSYI-----------------
-------L----------------------------------VNTLEPMEDD----AEVR
----GDQGTPTTGLL-------MIVLGLIFMKGNT------ITET---EVWDFLRRL---
-----GVY-PTK----KHLVFGDPKKLITEDFVRQ------RYLEYRRI-PHTDPVDYEL
----QWGPRTNLETS--KMKVLKFVAKIHKQDPK----D-WPAQYCE---ALADEEKRAR
PAIN-APASLLN------------------SEM---------------------------
----------------------GSEGL-------------------------------GQ
GSG--TQR------HRAKE-----------------------------------------
------------------------------------------------------------
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--------------------------------------MPRGQK---STLRAREKC-QRT
-WG-----QIQGH-----------------------------------------------
-QG-------------AQMTATQK------------------------------------
-----------------------------------------------------------K
-KVS-------------------------FSSPL-----I---------------LEATI
QKKS-A------------------------GRSGS-------V-------LKKPQR---A
L--STT-TSV-D------------------------------------------------
------------------------------------------------------------
-----------------AY----HKKSYKGA---------------NS-K-IE-KKQ---
-----------------------------SF-SQGLSSTVRSRTDPLTIKTNMLV-----
-------QFLMEMYKMKKPIM-KADML--KIVQKRHE-----NHFPEILKKASFN-----
----MEVVFGVD---------LKK-VDSTK---------DSYV-----------------
-------L----------------------------------VSKMDL-PNN----GTVT
----RGRGFPKTGLL-------LNLLGVIFMKGNC------ATEE---KIWEFLNKM---
-----RIY-DGK----KHFIFGEPRKLITQDLVKL------KYLEYRQV-PNSDPARYEF
----LWGPRAHAETS--KMKVLEFWAKVNQTVPS----A-FQFWYEE---ALRDEEERVQ
AA-ATFNDGSS-AM----------------------------------------------
----------------------------------------------------------GR
--------------------KCSKVK-----------------------ASS---SSHA-
------------------------------------------------------------
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---------------------------------------MDRRNDYGYRVPLFQ--G---
--------PLPPP--GSLGLP----------------------------FPPDIQTETTE
EDSV-LLMHTLL-------AATK--DSLAMDPPVVNRPKK-------------SKTKKAP
IKTI----------TKA-APA--APPVPTANEIATNKPKITWQALNLPVITQISQALPT-
T------------------------------------------------EVTN-------
------TQASSVTAQPKKANKMKRVTAKAAQG-SQSPTGHEGGTIQLKSPLQVLKLPVIS
QNIHA---PIANESASSQAL-ITSIKPKKAS---------------KAK-----------
-------------KAA----------------NKAIASATEVSLAATATHTA-TTQGQIT
-NETASIHTTAASIRTKKASKARKTIA--KVINTDTE-------HIEALNV---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------TDAAT
RQIEA--------------------S---------------------------------V
VAIRPKKSKGKKAASRGP---------N------------SVSEISEAPLATQMVTNQAL
AATLRVKRGS----RARKA----ATKARATESQT----PNADQGAQAKMASAQ-TNVSAL
ETQ------------VA------------AAVQALADDYLAQL----SLEPTTRTRGKRN
RK-----------------------------------------------SKHLNGDERS-
GSNYRRIPWGRRPAP-PRDVAIL---QERANKLVK------YLLVKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LRDVIQEYDEYFPEIIERASYTLEKMFRVNLKEIDKQSSLYI-LISTQES
SAG-IL-GTTKDT-PKLG---LLM----------VILSV----------IF--------M
-NGNK----A-S--EAVIWEVLRKLGLR--PGVRHSLFGEVRKLITDEFVKQK-------
---------YLEYKRVPNSRP---P--EYEFFWGLRSYHETSKMKVLKFACKVQKK---D
------PKDWAVQYREAVEMEVQAAAVAVA--EAEAR----AEARAQMGIGEEAV-----
------AGP--WNWDDMDIDCLT-REELGDDAQAWS-RFSF----EIEARAQENADASTN
VNFSRGASTRAGFSDGANISFNGAPSS--SGGFSG-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------GPGITFGVAPSTSASFSNTASISFGGTLSTSS----------------
--------------------SFS------------------S----------------AA
SISFGGAPSTSTSFSSEASISFGGMPCTSASFSGGVSSSFSGPLS--TSATFSGGTSSGF
GG------------------TL-STTAGFSGVLSTSTSFGSAPTTSTVFSSALSTSTGFG
GILSTSVCFGGSPSSSGSFGGTLSTSICFGGSPCTSTGFGG----TLSTSVSFGGSSSTS
ANFGGTLSTSICFDGSPSTG-AGFGGALNTSASFGSALNTS-------------------
-------------------------------------------------TGFGGAMSTSA
DFGGTLSTSVCFGGSPGTSVSFGSALNTNAGFGGAVSTNTDFGG----------------
------------------------------------------------------------
-----TLSTSVC------------------------------------------------
----------------------FGGSPSTSAGFGGALNTNASFGCAVSTSASFSGAVSTS
ACFSGAPITNPGFGGAFSTSAGFGGALSTAADFGGTPSNSIGFGAAPSTSVSFGGAHGTS
LCFGGAPSTSLCFGSASNTNLCFGGPPSTSACFSGATSPSFCDGPSTSTGFSFGNGLSTS
AGFGGGLNTSAGFGGGLGTSAGFSGG------------------------------LSTS
SGFDGGLGTSAGFGGGPGTSTGFGGGLGTSAGFSGGLGTSAGFGGGLVTSDGFGGGLGTN
ASFGSTLGTSAGFSGGLSTSDGFGSRPNASFDRGLSTIIGFGSGSNTSTGFTGEPSTSTG
FNSGPSSIVGFSGGPSTGVGFCSGPST-SGFSGGPSTGAGFG------------------
------------------------------------------------------------
-------GGPNTGAGFGGG-PSTSAGFGSGAASLGACGFSYG

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------------------------------MPR---------------------------
----------------------GNKSK---------------------------------
-SR-----------------SRAKRQ-QARGESQS---LQGALPTAKEE--------AA-
-AT-------------------PLG-QGD-APSSPDVSTPQGSQ-K-------------A
---------ASHG---S-------------PELDMPCSGYEVG---------AESS VAGV
DEKRANACTIAEAID-SARRDPM---TRKASKVLH------YLLEKY-QKDEQP--LE--
------------------------------------------------------------
----ADM---LKLISRKYKVHFPWILEKATYQLEVVYGLELKADKQNPQSYV-LVSKLPI
LPGANE-GGRKEL-PKTG---LIL----------TLLGM----------IM--------M
-KGDR----A-S--EEEVWQFLHMQGIY--PGRRHLIFGEPRKFITKELVEQN-------
---------YVEYRQVPGSNP---P--SYEFLWGSRARNEDTKMKVLDVLTKIRNA---M
------PSYYPQQYEEALSNQAERAARRGE-ASGYHAA---RVPS----HFHSTSSSHT-
------------------------------------------------------------
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--------------------------------------MPRGQK---SKLRAREKR-RKA
-RD-----ETQGL-----------------------------------------------
-NV-------------PQVTEAEE------------------------------------
-----------------------------------------------------------E
-EAP-------------------------CCSSS-----V---------------SGGAA
SSSP-A-------------------------AGI----------------PQKPQR---A
P---TTAAAAAA------------------------------------------------
------------------------------------------------------------
----------------GVS----STKSKKGA---------------KS-Q-GE-KNA---
-----------------------------SS-SQASTSTESSSEDPLTRKAGMLV-----
-------QFLLYKYKIKESVT-KGEML--KIVGKRFR-----EHFPEILKKASER-----
----LSLVFGLE---------LNK-VKPNG---------HTYT-----------------
-------F----------------------------------NSKVDL-TDE---ECL-L
----STWDFPRSGLL-------MPLLGVIFLNGNS------ATEE---EIWEFLNML---
-----GVY-DGE----EHLVFGEPRKLITQDLVEE------KYLEYKQV-PNSDPPRYQF
----LWGPRAYAETS--KMKVLEFLAKVNGTTPC----A-FPAHYEE---ALRDEGKAGV
------------------------------------------------------------
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-------------------------------------QSPLQIPVSASFSS---------
TLLSIFQSSPDSTQSTFEGF--PQSPLQIPVSPSISSTLLSLFHSSPERTQSTFEGFPQS
PLQIPVSPSISSTLLSIFQSSPERTQSTFEGFPQSPLQIPVSPSFSSTLLSLFHSSPERT
QSTFEGFPQSPLQIPVSPSISSTLLSLFQS---SPERTQSTFEGFPQSPLQIPVSPSFSS
TFLSIFHSSPERTQSTFEGFPQSPLQIPVSP---SFSSTLLSL----FQSSPERTQSTFE
GFPQSPLQIPVSPSFSSTFLSIFQSSPESTQSTFEGFPESPLQIPVSASFSSTLL----S
IFQSSPDSTQST---FEGFPQSPLQIPVSPSISFTLLSLFQSSPERTQSTFEGFPPSPLQ
IPVSPS-----ISSTLLSIFQSSPERTQSTFEGFPQSPLQIPQSPPEGENTHSPLQIAQS
IPEWEDSLSPHYFPQSPPEGEDSLPPHYFPQSPPQGEDSLSPHYIPQSPPQGEDSLSPHY
F--PQSPPQGEDSLSPHYFPQNPPEGEDSLSPHYIPQ-----SPPEGEDSLSPHYIP---
-----------------QSPPQGEDSLSPHYIPQSPPQGEDSLSPHYFPQSPPQGEDSLS
PHYFPQ---NPPEGEDSLSPHYIPQSPPEGEDSLSPHYIPQSPPQGEDSLSPHYF--PQS
-P--PEGEDSLSPHYIPQSPQSPPEG-E----------------DFQSSLQSPVS-ICS-
-------------SS---------------TSLS-----------------LPQ------
---SFPESPQSP-----------------------------------PEGPAQSP--LQR
P-----------------------------VSSFFSYTLASLLQSSY----------ESP
Q--------------------------------------------SPPEGPAPSPLQSPV
S-----------------------------------------------------------
------------------------------------------------------------
-----SFS--------S-S--ASLSPFSE----------------QSSNP-VDED-T---
------------S------TSDTLLESDSLTESESLIESEPLFTHTLDEKVDELV-----
-------QFLSLKYQAKQPVT-KAEML--TNVISRYT-----GYFPVIFRKAREY-----
----MEILFGIS---------LRE-VDPD----------DSYV-----------------
-------F----------------------------------VNTLDL-TSE----GS--
LS-DE-QGMPQNPLL-------IFVLSIIFMKGTC------ASEE---VIWYVLNGM---
-----GVY-AGR----EHFVFGEPRELLTKVWVQE------HYLEYQEV-PNTSPPCYEF
----LWGPRAHSEII--KRKVVEFLAMLNNTVPV----S-FPSSYKD---ALKDAEKRAQ
AIIDTTDDS-T-------------------------------------------------
------------------------------------------------------------
-----------------------AT------ESA----------------SSS--V----
------------------------------------------------------------
---------MSP---------------------SFSS-----------------------
------------------E-----------------------------------------
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--------------------------------------MSQRQ-----------------
-----------------KNP-ECAAD-Q----------------G-QT----CDE-TQG-
-------------LQVAAVS----------------------------------------
-------------------------------------------------------N---D
MEEP----------------------------CSSSHLMAS------------------S
LKSQPC---------------------------------------K------------DA
EEPCTS-SHSLM----ASY---QN------------------------------------
---------YP--------------------------------------ADET---PSTS
RGLQSPCA---SSG--A-G--L-SNQQVQ----------------GYP-------LY---
------------P------TF--QQ------------DTMNVPMMSVDNKVDFLV-----
-------NYMLYKYQMREIMS-MTDIL--RRIVREDE-----YRYHEILMRAAER-----
----MEMVFGLD---------LKE-VDPVN---------HCYA-----------------
-------L----------------------------------FIKLGL-TYD----GM--
RS-DQ-YSFPKTGFL-------ILILGVVFMKGNR------ATED---EIWEVLNPM---
-----GIY-SGM----NNFVFGDPRKLITEEFVKE------QYLVYQPV-ANSNPVQYEY
----VWGPRARFETS--KMKVLEFVAKVHGTDPT----A-FQSQYEE---ALIEEEERTL
TMILNSAGPRS-------------------------------------------------
------------------------------------------------------------
-----------------------S-------SGA----------------SSS--A----
------------------------------------------------------------
---------MGS---------------------SF-------------------------
------------------PHI---------------------------------------
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-----------------------------------------------------MSEQSKD
LSD---------------------------------------------------------
------------------------------------------------------------
--------PNL----------------------------A---------------AEA-L
NSQM--------------------------HDS-----------------PGVPAG---V
P--PPPESPAAT---------LGGPSTAPVGP------------T---------------
----ASPQAA--------------------------------------------------
------PPP--------------EERFEDID---------PKIL-QQA-A-EE--GR---
----------------------AHQPQ----SPPQPL-PAPPAPAQLVQKAHELM-----
-------WYVLVKDQKRMILW-FPDMV--KDVMGSYK-----KWCRSILRRTSLI-----
----LARVFGLH---------LRL-TNLHT---------MEFA-----------------
-------L----------------------------------VKALSPEDLD-----RVA
----LNNRMPMTGLL-------LMILSLIYVKGRG------ARES---AVWNVLRIL---
-----GLR-PWK----KHSTFGDVRKLITEEFVQQ------NYLKYQRV-PHVEPPEYEF
----FWGSRARREIT--KMQIMEFLARVFRKDPQ----A-WPSRYRE---ALEEARALRE
ANPAA----------------------------------HCPRSSVSDD-----------
------------------------------------------------------------
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--------------------------------------MPRGQK---SKQRSRVKR-RQA
-RA-----HTQRV-----------------------------------------------
-EG-------------AQATAAEE------------------------------------
-----------------------------------------------------------A
-GAP-------------------------SS-SP-----A---------------LRGLP
RSSP-T-------------------------ARV----------------PWEALR---V
P--PITTVV---------------------------------------------------
------------------------------------------------------------
-----------------AS----GAGAFGGA---------------WA-R-DA-GGP---
-----------------------------ST-SEPPPSAGGSQKDSLGRQAGILL-----
-------QFLLNRYKMKAPVT-KAEML--KRVCRKYQ-----RHFPEILRRTTER-----
----MEMVFGLD---------LKE-VDRSA---------QSFA-----------------
-------V----------------------------------VSNLDI-KDE---ERL-T
----AAGEIPKNGLL-------MPLLGVIFMKGNR------ASEE---DIWEFLNSL---
-----GVY-DGK----WHAIYGEPRRLITKDFVQR------KYLVYQQV-PSSDPPRFEF
----LWGPRAHAETS--KMKVLRFLAKALDVIPS----A-FPEQYDE---ALRDEEMRAQ
ARRAAAGAGPA-AG----------------------------------------------
----------------------------------------------------------AR
--------------------AGY--R-----------------------ATPS-SFH-PF
------------------------------------------------------------
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--------------------------------------------------MLQKPE---S
G--------------------------------------------------ALPIP----
-------QAE----------------------------REMDGSHDGETQPLT-----A-
-SQEMAPSPLLQE----------SPEEDLGA---------------VREE-G--------
----------------ASEPSLTPKGA--RA-LAAKTLARRRACRRLDRTVAELV-----
-------QFLLLKDRKKSPIT-RSEMV--KYVIGDLK-----DLFPEIIARAAEH-----
----LRYVFGFE---------LKQ-LDRKH---------HTYI-----------------
-------L----------------------------------INKLKPIEHE--------
-EEALGGDGPRLGLL-------MMILGLIYMKGNS------AREA---QVWAMLRRL---
-----GVR-PSK----YHFLFGYPKRLIMEDFVQL------RYLNYRRV-PHTNPPECEF
----SWGPRSNLETS--KMKVLGFVAKLHKKEPQ----H-WPVQYRE---ALADEADRAR
AGAS-V----RA----------RA--------S---------------------------
------------------------------------------------------------
-TH----L------W---------------------------------------------
------------------------------------------------------------
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----------------------------------------PESTDILTMKLSLLE-----
-------QFLLYKYKMKQPIT-KEDLL--KIIGQNYK-----DQYPEILKKASER-----
----IEVVFAVD---------LKE-VDSTR---------QSYD-----------------
-------L----------------------------------VSKVKL-PNN----GRVR
----AGRGLPKTGLL-------MTVLGVIFMKGNC------ATEE---DIWKFLGSM---
-----LGL-EML----RSIC----------DVISK------HAVVYNSH-PEAD------
------------------------------------------------------------
-----------------CKNGGLMKLSGSACFL---------------------------
----------------------CHKSK-------------------------------LQ
ASE--------------------RRR-RARGEAQA---KA-AQATAAVEEESA-TSSSP-
-QC-------------------EDA-AQS-LPPAGSSSTSQERQ-G------------AQ
---------ATTI---T-------------HTAV-SCTKSDED---------SNSQ----
DEERVSPCEALYYIE-NPGEDSL---TRKPGLLEQ------FLLYKY-KMKQPI--LK--
------------------------------------------------------------
----EDM---LKIIGQNYEDRFPEIIKKASERIEIVFAVDMKEIDSTRQSYN-LISKLKL
PNNGRV-RAGRGL-PKTG---LVM----------NILGM----------IF--------M
-KGNC----A-A--EEDIWKFL--------------------------------------
---------------------------------GPKALAETSKMKVLEFLAKVNDT---I
------PTAFPSYYEEALQDEKERVQTKAM-VRASNIAKV-IIPA----RATS-------
---QNIFPP---------------------------------------------------
------------------------------------------------------------
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--------------------------------------MPRP-C----------------
-----------------KRR-RCMVE-G----------------EPEA----QS--ET--
------------------VSIG-E------------------------------------
------------------------------------------------------------
V-DS-----------------------SSSSTCSSSFPSSFSSS----------------
-----------------------------------------------------------S
------SYSGST----ASP--SEEA--F--------------------------------
----------V--------------------------------------DSRT---SGPS
HSPPGADS---SCTAMI-S--FPCSQFS-------------------ADS-ETEESP---
------------D------SSEVLP------------CVCSLSRDEIDAKVDELV-----
-------KYLLFKYLMKEPVT-KAEML--NNIIRNYQ-----DHFPVIFREALEC-----
----MQLIFGIE---------VKK-VGPDD---------HTYI-----------------
-------L----------------------------------VIALEL-TYD----GMMT
---DV-QGIPKTGLL-------IMVLSIIFMKGNC------ISED---MIWAMLSNI---
-----GLY-AGN----DHFIYGEPRKLITNDFVQE------GYLEYRQV-SGSYPPSYEF
----LWGPRAYAETT--KMKILMFLASISGNDPR----S-YSVLYAE---ALREEEERA-
------------------------------------------------------------
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----------------------LGQVSTMFSEDDFQST---ERAPYGPQL----------
---------QWSQDLPRVQVFRE----------QANLE---DRSPR-RTQRITGGEQV--
-----------------LWGPITQIFPTVRPADLTRVIMPLEQ-----------------
-----------------RSQ-HCKPE-E----------------GLQA----QEE-DLG-
-------------LVG-AQALQAE------------------------------------
-----------------------------------------------------------E
Q-E---------------------------------------------------------
------------------------------------------------------------
---AAFFSSTLN----VGT--LEE------------------------------------
---------LP--------------------------------------AAES---PSPP
QSPQEESF---SPTAMD-A--IFGSLSDE----------------GSSS--QEKEGP---
------------S------TSPDLI------------DPESFSQDILHDKIIDLV-----
-------HLLLHKYRVKGLIT-KAEML--GSVIKNYE-----DYFPEIFREASVC-----
----MQLLFGID---------VKE-VDPTS---------HSYV-----------------
-------L----------------------------------VTSLSL-SYD----GIQC
---NE-QSMPKSGLL-------IIVLGVIFMEGNC------IPEE---VMWEVLSIM---
-----GVY-AGR----QHFLFGEPKRLLTQNWVQE------KYLVYRQV-PGTDPACYEF
----LWGPRAHAETS--KMKVLEYIANANGRDPT----S-YPSLYED---ALREEGEGV-
------------------------------------------------------------
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--------------------------------------MPRGQK---SKLRAREKR-RQN
-RA-----EAQGL-----------------------------------------------
-KS-------------AQAATAEE------------------------------------
------------------------------------------------------------
-EAT-------------------------ASSPP-----V---------------TGDGA
SSSS-V-------------------------AGS----------------LQAPAR---V
S--AAASAAA--------------------------------------------------
------------------------------------------------------------
----------------GVS----CRRSDVRA---------------KS-R-VQKSEN---
--------------------------------SQAAPSSESSGHDLLTRKAGMLM-----
-------HFLLCKYKMNEPIK-KGDML--KVIHKRYR-----EHFPEILKKASER-----
----MDLVFGLE---------LKE-VKPNG---------HSYS-----------------
-------L----------------------------------VCKLDD-SRD----ESTS
----NALRFPTKVIL-------MPLLGLIFLNGNR------ASEE---EIWELLNIL---
-----GVY-DEE----THCILGEPRDIITQNLVQE------KYLEYRQV-PGSDPPRFEF
----LWGPRAQAETT--KGKVLDFLCKVNDTFPT----D-FPPHYEE---LLRDEKERAR
ATAA-TMA----------------------------------------------------
-----------------------------------------------------------G
--------------------ATDKA------------------------------RA---
------------------------------------------------------------
------------R-----------------------------------------------
------------------SRATS---S-RDPPHE--------------------------
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-------------------------------------------MFKD---RLAGRKESQA
TVGAKGKIGRGPHLLILFPGLPPVPDRGAIMPR---------------------------
----------------------RRKNK-------------------------------SK
--------------------ARERGH-QAQGEAQG---REDAQAKAAAEAEST-PSSTA-
---------------------QCEDTTQS-VPTTGSSGASQRRR-R-------------R
---------ARAA---A--AA-AAAAAAAATSGAVPGTKSDEE-------------SNNQ
DGERASPYEAPVYAE-GPGEDSL---SRKPGLLEQ------YLLYKY-KMKQPI--LK--
------------------------------------------------------------
----EDM---LKIIGPNYEERFPEILKKVAERIEIVFAVDLQEIDSTR--YD-LISKLKL
PNNGRV-RPGRGL-PKTG---LLM----------NILGM----------IY--------M
-KGNC----A-A--EEDIWKFLGLMRIY--PGRKHFIYGEPRKLITKDLVRLQ-------
---------YLEYRQVANSDP---P--RHEFLWGPNALAETTKMKVLQFLSKVNDT---I
------PTAFPSYYEEALREEGERAQARGA-TGVGLPARVLIPSSVMARSIFPPLLRSDG
------SNPF-D------KILQG-RSKN--------------------------------
------------------------------------------------------------
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--------------------------------------MPRGQK---SKRRGREKR-RQA
-RM-----ETKDL-----------------------------------------------
-GN-------------AQAAA---------------------------------------
------------------------------------------------------------
------------------------------SPTP-----T---------------SGSTP
PGSP-P-------------------------AGA----------------GQKPQG---A
A--ATSSPVA--------------------------------------------------
------------------------------------------------------------
----------------GAA----RPRSKARG---------------RG-Q-VEEHEN---
------------------------------S-SQASTSAKTAPPDPLTKKAGDLV-----
-------NFLLDKFKMKEPIM-RIDML--KLFHKRYK-----TRFPEILRRATEC-----
----MELAFGLE---------LKE-VKPNG---------YSYT-----------------
-------L----------------------------------VSKIGL-ISN----EVLS
----SSSEVPKNGLL-------MPLLSVIYLNGNR------ASEA---DVWKFLNVL---
-----GIY-DGK----QHVIFGDPRKLITEEWVQQ------NYLVYRQI-PDSDPLSYEF
----LWGSRAYAETS--KMKVLEFLAKINSTVPS----A-FSLHYAE---ALRE-EKRSR
GRSL-VRS----------------------------------------------------
-----------------------------------------------------------R
--------------------GAARA------------------------------TA---
------------------------------------------------------------
------------R-----------------------------------------------
------------------SRVPP---R-YLSSA---------------------------
------------------------------------------------------------
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---------P----------------------------------------LSA-------
----------P-----------QAVH--CPPIIWQAPKGQAPVPHE--------------
------------------------------------------------------------
------------------------------------------------------------
---------LPTSMEFQEVQQ-AQ-AL--AWQAPKAP-----GQFWQPVPTQEAQRQ---
----GPPLVQLE-------QPFQGVQASQKALQIQL-PTQQAQPS--GPQAELPTLQLQP
SWQGPPAALQGQPGAPLAAANFPVGSAKSLMTP-SGESRASSIERRTSS-KE----RRTS
SK--ERRAPSKDRM----------IFAATFCAPKA----VSAARAHLPTAWKNLPATSET
FTATSRVF-PTT----SRFQPASSNAFQGPSAPSE----TPKSLPLAL---QDPFACVEA
LPAVPWVPQPNVNASKAAQAVPTILM-ATAAAPK----A-MATT-QE---GSKTSAEPPR
RS-----------------------GKA--------------------------------
--TRK-----KKHLNTEE-DSNGQMLA-------------------------------LR
--D-WQAP----RPWENLN--LNDW--EVENPIQ-V--LGDWEGPSTSRGLSGWEGPSTS
-RI---------------LSG---WEGPSTTWALSAWEGPSTSR-A--------------
---------LGLW---------------ESPGSPQPLIISEFT-------------N---
LSQGFGATQNDPKLE-TQQLSPL---DERANALVQ------FLLVKD-QAKVPI--KR--
------------------------------------------------------------
----SEM---VKFIIREYKDECLDIINRANNKLQCVFGYQLKEIDPENHSYI-IINKLGH
HKGEPV-ASYLDR-PKLG---LLM----------VVLSL----------IF--------M
-KGNC----V-R--EDLIFSFLYRLGLD--VRETHALFGNTKKLITEVFVRQK-------
---------YLEYRQIPYTEP---A--EYEFLWGPRAFLETSKMLVLRFLAKLHKR---D
------PRCWPLQYFEALAECESEDLDEDE-PGS----GDNA-------GDP--------
---TSSSPPR--------------------------------------------------
------------------------------------------------------------
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------ME-----------------------G----------RRLTGRN-----------
------RDPLWRRKEAGPL---------------------------P----AREG-----
-----------------------------------------------DRLRRKE-RLGES
----------RRLLDSRRR-----------------------------------------
-----------------------GPFPSDSTVTRP-PRKMDRRNDYGYRVPPFQ--G---
--------PLPPP--GSLGLP----------------------------FPPDIQTETTE
EDSV-LLMHTLL-------AATK--DSLAVDPPVVNRPKK-------------SKTKKAP
IKAI----------TKA-APA--APPVPTANEIATNKPKITLQALNLPVITQISQASPT-
T------------------------------------------------EVTN-------
------TQVSSVTAQPKKANKMKRVTARAAQG-SQSPTGREGDATQLKSPLQVLNLPVIS
QNIHA---SIANESASSQTL-ITSIKPKKAS---------------KAK-----------
-------------KAA----------------NKAIASATEVSLAPTATHTA-TTQGQIT
-NETASIHTTAASIRTKKASKARKIIA--KVINTDTE-------HIQAANV---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------TETAT
RQIEA--------------------S---------------------------------V
IAIRPKKSKGKKAASRGP---------N------------SVSEISEALLATQMVTNQAL
AATLRVKRGS----RARKA----STKARATEIQT----PNADQGAQAKMASAQ-TNVSAL
ETQ------------VA------------AAVQALADDYLAQL----SLEPTTRTRGKRN
RK-----------------------------------------------SKHLNGDERS-
GNNYRRIPWGRRPAP-PRDVAIL---QERANKLVK------YLLVKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LRDVIQEYDEYFPEIIERASYALEKMFRVNLKEIDKQSSLYI-LISTRES
SAG-IL-GTTKDT-PKLG---LLM----------VILSV----------IF--------M
-NGNK----A-S--EAVIWEVLRKLGLH--PGVRHSLFGEVRKLITDEFVKQK-------
---------YLEYKRVPNSRP---P--EYEFFWGLRSYHETSKMKVLKFACKVQKK---D
------PKDWAVQYREAVEMEVQAAAVAVA--EAEAR----AEARAQMGIGEEAV-----
------AGP--WNWDDMDIDCLT-REELGDDAQAWS-RFSF----EIEARAQENADASTS
VNFSRGAGTRAGFSDGASISFNGAPSS--S----G-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------GPGITFGGAPSSSASFSNTASISFGGTLSTSS----------------
--------------------SFS------------------S----------------AA
SISFGGAPSTSTSFSSEASISFGGTPCTSASFSGGVSSSFSGPLN--TSATFSGAASSGF
GG------------------TL-STTAGFSSVLSTSTSFGSAPTTNTVFSSALSTSTGFG
GTLSTSVCFGGSPSSSGSFGGTLSTSICFGGSPCTSTGFGG----TLSTSVSFGGPSSTS
ANCGGTLSTSICFDGSPSTG-AGFGGALNTSASFGSALNTS-------------------
-------------------------------------------------AGFGGAMSTSA
DFGSTLSTSVCFGGSPGTSVSFGSALNTSAGFGGAVSTSTDFGG----------------
------------------------------------------------------------
-----TLSTSVC------------------------------------------------
----------------------FGGSPSTSAGFSGALNTNASFGCAISTSAGFSGAVGTS
AGFGGVPSTNPGFGGAFNTSAGFGGALSTTTDFGGTPNNSIGFGAAPSTSVSFGGAHSTS
LCFGGAPSTSLCFGSASNTNLCFGGPPSTSACFSGATSPSFGDGPSTSTGFSFGNGLSTS
AGFGGGLNTSAGFGGGLGTSAGFSGD------------------------------LSTS
SGFDGGLGTSAGFSGGPGTSTGFGGGLGTSAGFSGGLGTGAGFGGGLVTSDGFGGGLGTN
ASFGSTLGTGAGFSGGLSTSDGFGSRPNASFDRGLSTIIGFGSGSNTSTGFIGEPSTSTG
FHSGPSSIVGFSGGPSTGVGFCSGPSI-SGFSGGPSTGAGFG------------------
------------------------------------------------------------
-------GGPNTGAGFGGG-PSTSAGFGSGATSLGACGFSYG

------------------------------------------------------------
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------------------------------------------------------------
--------------------------------------MPRGQK---SKLRAREKR-HQA
-RC-----ENQDL-----------------------------------------------
-GA-------------TQATVAE-------------------------------------
------------------------------------------------------------
GESP-------------------------SSASL-----L---------------FGDRP
QNLP-A------------------------AETLS-------I-------PEALQG---A
P--STTNTIA-P------------------------------------------------
------------------------------------------------------------
-----------------VS----CTSSNEGA---------------GN-Q-DE-KSL---
------------------------------G-S--SREAEGWQEDPLSKKVVSLV-----
-------HFLLQKYEKKEPIT-KGDMI--KFVIRKDK-----GHFNEILKRASEH-----
----IELAFGVD---------LKE-VDPIR---------HYYA-----------------
-------F----------------------------------FSKLDL-TYD----ETTS
----DEEKIPKTGLL-------MIALGVIFMNGNR------APEE---AVWEIMNVM---
-----GIY-ADR----KHFLYGDPRKVMTKDLVQL------KYLEYQQV-PDSDPPRYEF
----LWGPRAHAETS--KMKVLEFVAKMHDTVPS----A-FPSRYEE---ALRDEEQRAQ
AR-VAARAHTA-AM----------------------------------------------
----------------------------------------------------------AN
--------------------ARS--R-----------------------TTSS-SFSHAK
------------------------------------------------------------
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---------------------------------------MSDT-----------------
---------------SE-SGA----------------------------GLTRFQAEASE
KDSS-SMMQTLL-------TVTQ--NVEVPETPKAS------------------KA----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------LEVSEDVKVS-------KASGVS---------------KAT-----------
-------------EV---------------------------SKTPEAREAP-ATQASST
-TQLTDTQVLAA----EN--KSLAADT--KKQNADPQ-------AVTMPAT---------
----ETKK-----VSH--------------------------------------------
------------------------------------------------------------
--------------------------------------------------------VA--
-------------------------------DTKV-------------------------
----N-T--KAQETEA--------APSQAPADEP---------EP--ESAAAQSQENQDT
RPKVK--------------------A---------------------------------K
KARKVKHLDGEEDGS---------------SDQSQASGTTGGRRVSKALMASMARRASRG
PIAFWARRAS----RTRLA----A------------------------------------
------------------------------------WARRALL----SLRSPKARRGKAR
RRA---------------------------------------------------------
-AKLQS-SQEPEAPP-PRDVALL---QGRANDLVK------YLLAKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LKDIIKEYTDVYPEIIERAGYSLEKVFGIQLKEIDKNDHLYI-LLSTLEP
TDAGIL-GTTKDS-PKLG---LLM----------VLLSI----------IF--------M
-NGNR----S-S--EAVIWEVLRKLGLR--PGIHHSLFGDVKKLITDEFVKQK-------
---------YLDYARVPNSNP---P--EYEFFWGLRSYYETSKMKVLKFACKVQKK---D
------PKEWAAQYREAMEADLKAAAEAAA--EAKAR----AEIRARMGIGLGSE-----
----NAAGP--CNWD-------------EADIGPWA-KARIQAGAEAKAKAQESG--SAS
TGASTST------NNSA--S--ASAST--SGGFSAGASLTATLTFGLFAGLGGAGASTSG
SSGACG-FSYK-------------------------------------------------
------------------------------------------------------------
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------------------------------------------

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------------------------------------------------------------
--------------------------------------MPLEQ-----------------
-----------------RSQ-HCKPE-E----------------GLEA----RGE-ALG-
-------------LVGAQVPVTEK------------------------------------
-----------------------------------------------------------Q
E-T---------------------------------------------------------
------------------------------------------------------------
----ASSSSTLV----EVT--LGE------------------------------------
---------VS--------------------------------------AAD------PQ
----GAST---LPTIIN-C--TLWSQSDE----------------GSSN--QEEEGP---
------------S------TFPDL---------------ETGFQAALSRKVAELV-----
-------HFLLLKYRAREQFT-MAEIL--E-----------SYFFPVIFSKASEY-----
----LQLVFGIE---------VME-VVPIS---------HLYI-----------------
-------L----------------------------------VTCLGL-SYN----GLLG
---EN-QIMPTTDLL-------IIILATVAIEGDG------APEE---KVWEELSVL---
-----ELS-GRR----EDSVLANPSKLLTQVLVQE------NYLEYRRV-PFSDHACYEF
----LWGPRALVETN--YVKVLYHMLKITGEPRI----S-YPPLHEW---AWREGEE---
------------------------------------------------------------
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---------------------------------------MSDT-----------------
---------------SE-SGA----------------------------GVTRFQAEASE
KDSS-LTMQTQL-------TVTQ--NVEAPETPKAS------------------KA----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------PEISEDVKVS-------KASGVS---------------KAT-----------
-------------EV---------------------------SKTPEAQEAP-ATQASST
-TQLTDTPVLAA----EN--KSPAADT--KKQNADPQ-------AVTVPAT---------
----ETKK-----ASC--------------------------------------------
------------------------------------------------------------
--------------------------------------------------------VA--
-------------------------------DTKV-------------------------
----N-A--KAQETEA--------AASQAPADEP---------E--PESTAVQAQENQDT
RPKVK--------------------A---------------------------------K
KARKVKHLDGEEDGS---------------SDQSQASGTTGGRRVSKALMASMARRASRG
PIAFWARRAS----RTRLA----A------------------------------------
------------------------------------WARRALL----SLRSPKARRGKAR
RRA---------------------------------------------------------
-AKLQS-SQEPEAPP-PRDVALL---QGRANDLVK------YLLAKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LKDIIKEYTDVYPEIIERAGYSLEKVFGIQLKEIDKNDHLYI-LLSTLEP
TDAGIL-GTTKDS-PKLG---LLM----------VLLSI----------IF--------M
-NGNR----S-S--EAVIWEVLRKLGLR--PGIHHSLFGDVKKLITDEFVKQK-------
---------YLDYARVPNSNP---P--EYEFYWGLRSYYETSKMKVLKFACKVQKK---D
------PKEWAAQYREAMEADLKAAAEAAA--EAKAR----AEIRARMGIGLGAE-----
----NAAGP--CNWD-------------DADIGPWA-KARIQAGAEAKAKGQESG--SAS
TGTSTST------NNSA------SAST--GGGFSAGTSLTATLTFGLFAGLGGAGASTSG
SSGACG-FSYK-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------

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------------------------------------------------------------
------------------------MWAVS---------------------TSILESARLL
FLKALPLEVPWKSRGSPVEV----------------AGGGKALRPV----------GSI-
-------------------TLAYPHSCQ---LSPIQSMMPHSQ-----------------
-----------------KHQ-QYKLQ-D----------------ERKT----Q-----A-
-------------LVD--------------------------------------------
---------------------------------------------------GQVP-----
--A---------------------------------------------------------
---------------------------------------------------------AEE
VDTTAAASSTLM----PGT--PDNVP----------------------------------
---------AA--------------------------------------TPRT---PSLP
KSLQKSSS----STARK-A--TPSSKSNK----------------GSRGQ-VGKH-Q---
------------S------TSQARP------------YPEFLLTNILEKKVIELV-----
-------KFLSVKYATKELVT-EVDMV--KNVIREHK-----DDLPEIFKNACEW-----
----MRMIFGID---------VKQ-VDPIS---------HSYV-----------------
-------L----------------------------------VKALEL-TYD----GRLS
---ED-QCIPKTGLL-------ILVLGIIFMEGNC------APEE---KIWEMLQKI---
-----GVY-PEK----KDFICANPRKFITKELVQE------RYLKYRQI-PNSDPARYEF
----LWGPRAYAETT--KMKILEFFSNAIGSSPT----D-FPSLYRE---ALRDEEEKAQ
PVTAAEDCTTA-------------------------------------------------
------------------------------------------------------------
------------------------P------VGT----------------QAS--T--K-
------------------------------------------------------------
---------HSS-----------------------SG-----------------------
------------------PQ----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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--------------------------------------MPPS-P----------------
-----------------KRL-RLTFE-P----------------DFQT----QSE-IQG-
-------------LEVADVLITED------------------------------------
-----------------------------------------------------------K
D-ET-----------------------SSVSSCSFNF--SYPST----------------
-----------------------------------------------------------S
---ASPPSSPVI----PVS--PEEEEER--------------------------------
-----E-PAAT--------------------------------------LSPP-------
QSPQSS-H---SFSASWST-------SEG----------------V-SNS-QEEEDT---
------------S------SLQTSI------------DTESLPRDPLHEMVADLV-----
-------HFMVLKYRLKEPIT-EAEML--KVVIKRYK-----KQFPVIFKKASKC-----
----LEVICGID---------VKE-VDPTT---------HSYV-----------------
-------L----------------------------------VNSLDL-THD----EVLS
---DN-HSMPKNGLL-------IIILGVIFIEGNC------AHEE---DIWDFLNMM---
-----GVY-AGR----EHFIYGEPRKLITRDWVQE------NYLEYRQV-PNSDPPRYEF
----LWGPRAYAETS--KMKVLEFLAKIKGTDPI----S-FSCWYEE---ALRDEEGRAQ
PRIHSVDNTNA-------------------------------------------------
------------------------------------------------------------
-----------------------MY--------S----------------SNAV---FL-
------------------------------------------------------------
---------NRS---------------------FISF-----------------------
--------------------RI--------------------------------------
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--------------------------------------------------MLQTPE---S
R--------------------------------------------------GLPVP----
-------QAE----------------------------GQKDGGHDGETRAPT-----A-
-SQE-------------------RPKEELGA---------------GREE-G--------
----------------AAEPALARKGA--RA-LAAKALARRRAYRRLNRTVAELV-----
-------QFLLVKDKKKSPIT-RSEMV--KYVIGDLK-----ALFPDIIARAAEH-----
----LRYVFGFE---------LKQ-FDRKH---------HTYI-----------------
-------L----------------------------------INKLKPLEEE----EE--
EEEDLGGDGPRLGLL-------MMILGLIYMRGNS------AREA---QVWEMLRRL---
-----GVQ-PSK----YHFLFGYPKRLIMEDFVQQ------RYLSYRRV-PHTNPPEYEF
----SWGPRSNLEIS--KMKVLGFVAKLHKKEPQ----H-WPVQYRE---ALADEADRAR
AKAR-AEASMRARA--------SARA------G---------------------------
------------------------------------------------------------
-VH----L------W---------------------------------------------
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--------------------------------------MPRA-P----------------
-----------------KRQ-RCMPE-E----------------DLQS----QSE-TQG-
-------------LEGAQAPLAVE------------------------------------
-----------------------------------------------------------E
D-AS-----------------------SSTS-TSSSF----PSS----------------
-----------------------------------------------------------S
S-SSSSSCYPLI----PST--PEE--VSA---------------------ADE-------
----------T--------------------------------------PNPP---QSA-
---QIACS---SPSVVA-S--LPLDQSDE----------------G-FSS-QKEESP---
------------S------TLQALP------------DSESLPRSEIDEKVTDLV-----
-------QFLLFKYQTKEPIT-KAEIL--ESVIKNYE-----DHFPLLFSEASEC-----
----MLLVFGID---------VKE-VDPTG---------HSFV-----------------
-------L----------------------------------VTSLGL-TYD----GMLS
---DV-QSMPKTGIL-------ILILSIIFIEGYC------TPEE---VIWEALNMM---
-----GLY-DGM----EHLIYGEPRKLLTQDWVQE------NYLEYRQV-PGSDPARYEF
----LWGPRAHAEIR--KMSLLKFLAKVNGSDPR----S-FPLWYEE---ALKDEEERAQ
DRIATTDDTTA-------------------------------------------------
------------------------------------------------------------
-----------------------MA--------S----------------ASS----SA-
------------------------------------------------------------
---------TGS---------------------FSYP-----------------------
-------------------E----------------------------------------
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---------------------M-------SLVSQNARR----------------------
------------------------------------------------------------
------------------CNAEIT------------------------------------
-----------------------------------------------------------A
-DY---------------------------------------------------------
-----------------------------------------------------------S
D--GRGEIQA----------------TNASGP------------P-T-------------
---------------------------------------------------PM------V
----------VVDAPQ----CPQAPINLQCV---------------NTSQ-AV-------
---------QDT----N--DLEV--LID-EQSRRLGA---LRFHDPLEDRSIALV-----
-------NFMRMKSQKEGSIQ--QSEM--LEFLREYS-----DQFPEILRRASAH-----
----LDRVFGLN---------LRV-IDPQA---------DTYN-----------------
----------------------L-------------------VSKRGS-QIT----DRIV
----ESLDMPKASLL-------ALVLGHILLNGNR------AREA---SIWDLLLKV---
-----DMW---DKPQRINNLFGNTRNLLTTDFVRM------RFLEYWPV-YGTNPLEFEF
----LWGSRAHR--EITKM-----------------------------------------
------------------------------------------------------------
--------------------------E-------------------------------AL
K-----------------------F---VS----------------DAHDEEP-------
------------------------QSWPE-EYN------------KALEADKTKER---S
---------------------------------------------------------LT-
AG---L--------E-FWSED---TMNDKANDLVQ------LAISVS-EELLPI--HQ--
------------------------------------------------------------
----DEL---LAHTGKEFEDVFPNILNRATLILDMFYGLSLIEVDTSEHIYL-LVQQPES
EEEQVM-LESLGR-PTQE---YVM----------PILGL----------IF--------L
-MGNR----V-K--EANVWNLLRRFSVD--VGRKHAI--------TCKLMRQR-------
---------YLECRPLSYSNP---V--EYELLWGPRAHHETTKMKVLEYMARLYRK---R
------PQDWPEQYRQAVE-----------DEEARAKSEATTMFF----LGP--------
---M--------------------------------------------------------
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----------------------------------------MSQ-----------------
-----------------SSK-ECAAD-Q----------------G-QT----CEE-TQK-
-------------LQVAAAS----------------------------------------
-------------------------------------------------------V---D
VEEP----------------------------CSSSHLMAT------------------S
LKDQTS---------------------------------------EET------QVSKDV
EEPCSS-SQLLM----ASN---QD------------------------------------
---------DP--------------------------------------EDEI---PSTS
RGLQHPYD---SSSESA-E--GLDNQEVQ----------------GNP-------VI---
------------P------PD--QS------------DSTDLPVMTVDGKVDFLV-----
-------NYMLYKYQVKEMMS-MSDIM--TLIVREDE-----DRFHEILMRASER-----
----MEMVFGLD---------VKE-VDPIN---------HCYA-----------------
-------L----------------------------------FIKLGL-TYD----GM--
RN-DE-YSFPKTGLL-------ILILGVVFMKGNR------ATEE---EIWEVLNPM---
-----GIY-AGM----THFMFGDPRELITDEFVRE------QYLEYQPI-ANSDPIQYEY
----VWGLRAKAETS--KMRVLEFVAKVHGSDPT----A-FLSQYEE---ALIEEEERTL
TMLLEHASSSS-------------------------------------------------
------------------------------------------------------------
-----------------------T-------SGE----------------SSS--D----
------------------------------------------------------------
---------TSS---------------------NF-------------------------
------------------SYV---------------------------------------
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--------------------------------------MPRA-P----------------
-----------------KRR-RYMLE-E----------------DHQA----QS------
------------------VPTAEE------------------------------------
-----------------------------------------------------------E
D-DS-----------------------SSSSTCSSLSF----------------------
------------------------------------------------------------
------S-CSLS----LSS--PEG--LFT---------------------LSD-------
----------T--------------------------------------LSPS---QSLS
S--ASPSP---SPTAVV-S--TPLSQSDN----------------G-SSS-QKEEGP---
------------S------TSQALP------------DAESFPRNAINDKVGDLI-----
-------AFLLLKYRTKEMVT-ETEML--NIITEDYK-----DHFPVIFSEASEC-----
----MQLVFGID---------VKE-VDPSD---------HSYV-----------------
-------L----------------------------------VTTLGL-TYD----GMLS
---DG-QSMPKNGLL-------IFILSIIFMKGDS------VPEE---EVWEVLSAM---
-----GVY-VGR----EHFVYGEPRELLTKVWVQE------GYLEYRQV-PNSDPACYEF
----LWGPRAHAETS--KMSFLEFLAKINGSDPR----S-FPLWYEE---ALRDQEETDQ
SRIATTDNTTS-------------------------------------------------
------------------------------------------------------------
-----------------------MA--------S----------------ASS----SA-
------------------------------------------------------------
---------MSS---------------------SLFN-----------------------
------------------PE----------------------------------------
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--------------------------------------MPRGQK---SKRRAQEKR-RQA
-RSIAQ-----SP-----------------------------------------------
-QS-------------ALVTMVAE------------------------------------
-----------------------------------------------------------A
IESM----------------------------SL-----T---------------EEGG-
------------------------------AQPSA-------F-------SQERQG---G
P--PATNTPE-T------------------------------------------------
------------------------------------------------------------
-----------------GS----ESDSEEDA---------------QV-Q-DA-GRR---
-----------------------------GG-R--CRRAKCQREDPLNKRVVLLV-----
-------QFLLHKYHRKELIT-KADML--KIVVKKYK-----CHFNEIFRRASEH-----
----MELAFGVD---------VKE-VDPIR---------HCYA-----------------
-------L----------------------------------VNKLEF-TFD----NTAS
----EDDTMPRTGLL-------MIVLGVIFMKGNC------AREA---DIWEVLNMM---
-----GVY-ADK----QHFIYGNPKKTITEDMVRL------NYLEYREV-PNTNPPVFQF
----YWGPRAYAETS--KMKVLEFLAKIHDTVPS----A-FPTWYEE---ALRDEEARAR
AR-AEARARIA-AF----------------------------------------------
----------------------------------------------------------SS
--------------------ARA-AR-----------------------LSAG-NFGHAE
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-----------------------------MGLSTSRVAITLKPQDPMEQNVAELL-----
-------QFLLVKDQSKYPIR-ESEMR--EYIVKEYR-----NQFPEILRRAAAH-----
----LECIFRFE---------LRE-LDPEA---------HTYI-----------------
-------L----------------------------------LNKLGPVPFE-----GLE
----ESPNGPKMGLL-------MMILGQIFLNGNQ------AKEA---EIWEMLWRM---
-----GVQ-RER----RLSIFGNPKRLLSVEFVCT------CPRIQG-----LDRVQWEV
----I-------------------------------------------------------
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--------------------------------------MPFNQMG---------------
-----------------ELF---ELG-E----------------DYQD----PRE-NQG-
-------------LLVGHFFESDD------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------EETPSF----SDS--QEE------------------------------------
---------VS--------------------------------------DALI---PSYP
QNPHCAGP---SPAAME-D--IPWSESED----------------EGSSS-QDEEEP---
------------S------TLEVPE-----------DAESLLK-HALRLKVAKLV-----
-------VFLLLKYRAKEPTT-KEEML--SSVIEECQ-----DHFPEIFSEAVQC-----
----MQLLFGID---------VKE-VNSSN---------HTYV-----------------
-------L----------------------------------VTSLGL-TYD----GMVS
-N--G-PSMPKTGLL-------VMLLCVILVEGGC------ASEE---KVWAVLNDM---
-----EVY-DGR----EHFIYGDPRALITNIWVQE------QYVKYQQV-PNSDPARYEF
----LWGPRAHAETT--KFKVLEFLLRIHSGDAS----S-FASLSKG---PERDAEEKS-
------------------------------------------------------------
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-----------------------------------------------------MLEQSKA
LSD---------------------------------------------------------
------------------------------------------------------------
--------PTS----------------------------A---------------AEN-P
GSEA--------------------------PGS-----------------PGAPAG---V
L--PATPA---------------APPSPAAGR------------G---------------
----GGPCP---------------------------------------------------
------------------------------------------------------------
-------------------------------PAPQRGPARPASPEQLVQKAHELM-----
-------WYVLVKDQKKMVIW-FPDMV--KDVISSYK-----K---------CLI-----
----LARVFGLH---------LRL-TSLHT---------MEFA-----------------
-------L----------------------------------VKALEPEELN-----RVA
----LSNRMPMTGLL-------LMILSLIYVKGRG------TRES---AVWNVLRIL---
-----GLR-PWK----KHFTFGDVRKLITEEFVRQ------NYLKYQR------PPEYEF
----FWGSRASREIT--KMQIMEFLAKVFKKDPQ----A-WPSRYRE---ALEEARALRE
ANPTA----------------------------------HYPRSSVSED-----------
------------------------------------------------------------
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---------------------------------------MDRRNDSDYKMTPFQ--X---
--------XXXXX--XXXXXX----------------------------XXXXXXXXXXX
XXXX-XXXXXXX-------XXXX--X------XXX---XX--------------XXXXXX
XXXX----------XXX-XXX-----X----XXXXXXXXXXXXXXXXXXXXXXXX-----
----------------------------------------------------X-------
------XXXXXXXXXXXXXXXXXXXXX------XXXX----XXXXXXXXXXXXXXXXXXX
XXXXX---XXX------XXX-XXXXXXXXX----------------XXX-----------
-------------XX-----------------XXXXX--XXXXXXXXXXXXX-XXXXXXX
-XXXXXXX------XXXXXXXXXXXXX--XXXXXXXX-------XXXXXXX---------
----XXXX----------------------------------XXX---------------
---------------------------------------------------------X--
----XXXXXXXXXXX-------------------X--X-XXX-XX-X------------X
-----XXX-X----------------XXXX-XXX--------------------------
------------------------------------------------------XXXXXX
XXXXX--------------------X---------------------------------X
XXXXXXXXXXXXXXXX-X---------X------------XXXXXXXXXXXXXXXXXXXX
XXXXXXXX------XXXXX------XXXXXXXXX----XX-XXXXXXX----X-XXX-XX
XXX------------XX------------XXXXXXXXXXXXXX----XXXX--------X
XXX----------------XXXXXXXX-XXXXXXXXXXXXXXXXXXDRKSKHLNGDERG-
GGNYRWIPWGRRPP--LSDVAIL---QERANKFMK------YLLVKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LKDVI-EYDEYFPEIIERASYALEKMFRVNLKEIDKQSSLYI-LISIQES
SAG-IL-GTTKDT-PKID---LLM----------VILSV----------IF--------M
-NGNK----A-N--EAVIWELLPKLGLH--PGVRHSLFGEVRKLITDEFVKQK-------
---------YLEYKRVPNSRP---P--EYEFFWGLCSYHETSKMKVLKFACKVQKK---D
------PKDWAVQYREAVEMEVQAAAVAVA--EAEAR----AEARAQMGIGEEAV-----
------AGP--WNWDDMDINCLT-REELGNDAQAWG-RFSL----EIEARAQENANASTN
IDFSRGSSTRASYSDGASTSFSGVPSP--SNVFGD-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------RA----------------------------------------------
------------------------------------------------------------
GISFGGTCSTSASFSSVASISFGG-PCTSTNFSGGVSSSFSGPLN--TSTSFSGGASSGF
GG------------------IL-STPAGFSDALSMSTSFGSTLGTSAVFSGALSTSTGFG
GTLSTSVYFGGSPSSSARFGGKLSTSICFGGFPSTSTGFDG----VLSTSAGLAGAFSNS
TDFGGTPSTSFCFGDSPSTS-ASFGGTLSTSLGL--------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------LGGALNTSAGFSSAVSISIAFNSAPSANSGFGSVFSTS
TDFSGAPNTTTDFGSA----------------------------------------PSTS
ISFGGAPSTRFCFGSVSNTNLCFGGPPSTSTCFSGPTSASFGDGLSTSAGFSFCDGLSTS
TGFGGGLST---------------------------------------------------
---------------------------------------NSGFGGGLISSDIFGGGLGTN
AGFGSTLGTSADFSSGLSISDGFGGGPNTSFDGRLSTMIGFGSGSNTSTGFIGRPT----
------SIVGFGSGLSTDADFNGGPSS---------------------------------
------------------------------------------------------------
--SAGYGSG-----------PSNAAGFSGGATSLGACSFSYG

------------------------------------------------------------
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---------------------------------------MDRRNDYGYRVPLFQ--G---
--------PLPPP--GSLGLP----------------------------FPPDIQTETTE
EDSV-LLMHTLL-------AATK--DSLAMDPPVVNRPKK-------------SKTKKAP
IKTI----------TKA-APA--APPVPTANEIATNKPKITWQALNLPVITQISQTLPT-
T------------------------------------------------EVTN-------
------TQASSVTAQPKKANKMKRVTAKAAQG-SQSPTGREGGTIQLKSPLQVLKLPVIS
QNIHA---PIANESASSQAL-ITSIKPKKAS---------------KAK-----------
-------------KAA----------------NKAIASVTEVSLAATATHTA-TTQGQIT
-NETASIHTTAASIRTKKASKARKTIA--KVINTDTE-------HIEAPNV---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------TDAAT
RQIEA--------------------S---------------------------------V
VAIRPKKSKGKKAASRGP---------N------------SVSEISEAPLATQMVTNQAL
AATLRVKRGS----RARKA----ATKARVTESQT----PNADQGAQAKMASAQ-TNVSAL
ETQ------------VA------------TAVQALADDYLAQL----SLEPTTRTRGKRN
RK-----------------------------------------------SKHLNGDERS-
GSNYRRIPWGRRPAP-PRDVAIL---QERANKLVK------YLLVKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LRDVIQEYDEYFPEIIERASYTLEKMFRVNLKEIDKQISLYI-LISTQES
SAG-IL-GTTKDT-PKLG---LLM----------VILSV----------IF--------M
-NGNK----A-S--EAVIWEVLRKLGLR--PGVRHSLFGEVRKLITDEFVKQK-------
---------YLEYKRVPNSRP---P--EYEFFWGLRSYHETSKMKVLKFACKVQKK---D
------PKDWAVQYREAVEMEVQAAAVAVA--EAEAR----AEARAQMGIGEEAV-----
------AGP--WNWDDMDIDCLT-REELGDDAQAWS-RFSF----EIEARAQENADASTN
VNFSGGASTRAGFSDGASISFNGAPSS--SGGFSG-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------GPGITFGVAPSTSASFSNTASISFGGTLSTSS----------------
--------------------SFS------------------S----------------AA
SISFGGAPSTSTSFSSEASISFGGMPCTSASFSGGVSSSFSGPLS--TSATFSGGASSGF
GG------------------TL-STTAGFSGVLSTSNSFGSVPTTSTVFSSALSTSTGFG
GILSTSVCFGGSPSSSGSFGGTLSTSICFGGSPCTSTGFGG----TLSTSVSFGGSSSTS
ANFGGTLSTSICFDGSPSTS-AGFGGALNTSASFGSALNTS-------------------
-------------------------------------------------TGFGGAMSTSA
DFGGTLSTSVCFGGSPGTSVSFGSALNTNAGFGGAVSTNTDFGG----------------
------------------------------------------------------------
-----TLSTSVC------------------------------------------------
----------------------FGGSPSTSAGFGGALNTNASFGCAVSTSASFSGAVSTS
ACFSGAPSTNPGFGSAFSTSAGFGGALSTAADFGGTPSNSIGFGAAPSTSVSFGGAHGTS
LCFGGAPSTSLCFGSASNTNLCFGGPPSTSACFSGATSPSFCDGPSTSTGFSFGNGLSTS
AGFGGGLNTSAGFGGGLGTSAGFSGG------------------------------LSTS
SGFDGGLGTSAGFGGGPGTSTGFGGGLGTSAGFSGGLGTSAGFGGGLVTSDGFGGGLGTN
ASFGSTLGTGAGFSGGLSTSDGFGSRPNASFDRGLSTIIGFGSGSNTSTGFTGEPSTSTG
FNSGPSSIVGFSGGPSTRVGFCSGPST-SGFSGGPSTGAGFG------------------
------------------------------------------------------------
-------GGPNTGAGFGGG-PSTSAGFGSGAASLGACGFSCG

------------------------------------------------------------
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---------------------------------------MNRRNGYGYRTPALQ--A---
--------PLPPS--GSLGLP----------------------------FPLDVQTETKE
EDNV-LLMRSLL-------AATK--DP-----PVANRPKK-------------SKTKKTP
VKAI----------AKS-TSA--APAVPSATEI-ATKPKITLQALNLPIFAQISQGSAT-
I------------------------------------------------EAAN-------
------IQTSSGPAPPKKANKMKRITAKAALVSQCCPSGSEGVTAQLKSPLQAPNLPVIS
QTIQA---PVASELANSPAF-IASTKPKKTP---------------KSK-----------
-------------KAA----------------NKAVGSANEISLAI-----G-TTQGQIN
-NETANIQATAATIRTKKASKAKRTTA--KATNTDTE-------HLESLNA---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------TETAT
RQTET--------------------S---------------------------------A
AVLWPKKPKGKKVASKGP---------N------------SAFEVSEAPPATQMVTNQAL
VATLRVKRGS----RARKA----ATKVQVTESQT----QIADQGSPAKMATSQ-MSINAL
ETQ------------VA------------TAVQALADDYLAQL----SLEPTTRTRGKRN
RKS-----------------------------------------------KHLNGDERS-
SINYRRIPWGRRLSP-PRDVAIL---QERANKLVK------YLLVKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LKDVIQEYDEYFPEIIERASYALEKMFRVNLKEIDKQSSLYI-LISTQES
SAG-IL-GTTKDT-PKLG---LLM----------VILSV----------IF--------M
-NGNK----A-N--EAVIWEVLRKLGLH--PGVRHSLFGEVRKLITDEFVKQK-------
---------YLEYKRVPNSRP---P--EYEFFWGLRSYHETSKMKVLKFACKVQKK---D
------PKDWAAQYREAVEMEVQAAAVAVA--EAEAR----AEARAQMGIGEEAV-----
------AGP--WNWDDMDIDCLT-REELGDDTQAWN-RFSF----EIEARTQENADETTN
VNFNQEDSTRDSFSDGASISFNGAPSS--SGGFGGGGG----------------------
------------------------------------------------------------
---------------------------------------------------------ITF
GDAPSTSAGFSSVASISFGGTPSTSASFSSVASISFGSALNTSTSFTGGASINFGDTPST
SASFCSTASISFGGTPSTITSFSGGASISFDGAPSTSTSFSS----------------TA
SISFGGTPSTSTSFSGGASISFGGAPNISTNFSGGASISFDGAPN--SSTSFSGGASISF
GGTPCTSASFSAGASSSFGGTLNSITTGFSGALSSSTSFGSASTTSTVFSGALNTSTGFG
GTLSTSVCFGGSPISGSSFGGTLSTSICFGGCPSTSIGFGCASTSILSTSVSFGGSSSTS
SDFGGTLSTSVCFGGSPSTS-ANFDGALNSSAGFGGAISTSVGFGDAVNTSASFGS----
------------------------TLNSSAGFGSAISTGASFSGAFSSSAG---------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------FSSAINTSAGFDGAVSTCTGFGSALNSS
ASFGSVISTSASFGGALNSSSGFGSTLSTSAGFGNAHNTSASFDGVLNTSAGYGGAISTT
AGFSGAPSTNPGFGSAFSTSAGFSGALSITTNFGGTPSSNIGFDSAPSTSVSFDGAHSTS
LCFGGAPSTGLCFGSASNTNLCFGGSPSTSACFSGATSASFSDGPSTSAGFSFGNGLSTS
AGFGGGLSTSAGFGGSLSTSTGFGGSLGTSTSFDSGLGTSTDFSGGLSTSAGFGGGLSTS
AGFGGGLGTNADFGGGLGTVAGFGGRLGTGAGFGGGLGTSTGFGGGLVTTDGFGGGLGTS
AAFGSTLGTCSGFSGSLSTSDGFGSGPNASFDRGLSSIIGFGSGSNTSTGFPGEPSTGTS
FSSGPSSIVGFSGGPSTGAGFCSEPST-GGYGGGLSTGASFAGSSPGA-GFGVGLS----
------------------------------TSIGFSGGPSSSANFGGGLNTSAGFSGEP-
STSSGFGG----------G-PSTGDGFGGGATSLGACGFSYS

------------------------------------------------------------
-------MGDKDMPTAGMPSLLQSSSESPQSCPEGEDSQSPLQIPQSSPESD----DTLY
PLQSPQSRSEGEDSSDPLQRPPEGKDSQ---SPLQIPQSSPEGDDTQSPLQNSQS-----
-SPEGKDS-----LSPL--------EISQSPPEGEDVQSPLQNPASSFFSS---------
ALLSIFQSSPESTQSPFEGF--PQSVLQIPVSAASSSTLVSIFQSSPESTQSPFEGFPQS
PLQIPVSRSFSSTLLSIFQSSPERTQSTFEGFAQSPLQIPVSPSSSSTLLSLFQSFSERT
QSTFEGFAQSSLQIPVSPSFSSTLVSLFQSS---PERTQSTFEGFPQSPLQIPVSSSSSS
TLLSLFQSSPERTHSTFEGFPQSLLQIPMTS---SFSSTLLSI----FQSSPESAQSTFE
GFPQSPLQIPGSPSFSSTLLSLFQSSPERTHSTFEGFPQSPLQIPMTSSFSSTLL----S
ILQSSPESAQSA---FEGFPQSPLQIPVSSSFSYTLLSLFQSSPERTHSTFEGFPQSPLQ
IPVSSSS----SSSTLLSLFQSSPECTQSTFEGFPQSPLQIPQSPPEGENTHSPLQIVPS
LPEWEDSLSPHYFPQSPPQGEDSLSPHYFPQSP----------------PQGEDSLSPHY
---FPQSPQGEDSLSPHYFPQSPPQGEDSMSPLYFPQ-----SPLQGEEFQSSLQSPVSI
CSSSTPSSLPQSFPESSQSPPEG-PVQSPLHSPQSPPEGMHSQSPLQSPESAPEGEDSLS
PLQIPQ---SPLEGEDSLSSLHFPQ----------------------------------S
-P--PEWEDSLSPLHFP---QFPPQG-E----------------DFQSSLQSPVS-ICS-
-------------SS---------------TSLS-----------------LPQ------
---SFPESPQSP-----------------------------------PEGPAQSP--LQR
P-----------------------------VSSFFSYTLASLLQSSH----------ESP
Q--------------------------------------------SPPEGPAQSPLQSPV
SSFPSSTSSSLS----QSS--PVSS-----------------FPSSTSSSLSKS------
---------------------------------------------------SP---ESPL
QSPVISFS--------S-S--TSLSPFSE----------------ESSSP-VDEY-T---
------------S------SSDTLLESDSLTDSESLIESEPLFTYTLDEKVDELA-----
-------RFLLLKYQVKQPIT-KAEML--TNVISRYT-----GYFPVIFRKAREF-----
----IEILFGIS---------LRE-VDPD----------DSYV-----------------
-------F----------------------------------VNTLDL-TSE----GC--
LS-DE-QGMSQNRLL-------ILILSIIFIKGTY------ASEE---VIWDVLSGI---
-----GVR-AGR----EHFAFGEPRELLTKVWVQE------HYLEYREV-PNSSPPRYEF
----LWGPRAHSEVI--KRKVVEFLAMLKNTVPI----T-FPSSYKD---ALKDVEERAQ
AIIDTTDDS-T-------------------------------------------------
------------------------------------------------------------
-----------------------AT------ESA----------------SSS--V----
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--------------------------------------MPRGQK---SKLRAREKR-QQA
-RS-----EAQHL-----------------------------------------------
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P--STTTTSA-G------------------------------------------------
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----MVLAFGIE---------VKE-VNPTT---------HCYA-----------------
-------L----------------------------------VSKFQR-TSD----GRLR
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-----GIY-AGR----KHFIHGDPKKLITQDLVQE------RYLEYRQV-PNSDPPHYEF
----LWGPRAHAETS--KMKVLEFLANIHDTVPS----A-FPSWYEE---ALRDEEERAR
AR-FAAMLRTS-AL----------------------------------------------
----------------------------------------------------------AN
--------------------VHS--G-----------------------GSGRHSFSHLQ
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YR-----K-E-------SEGYNVEDMDEGSDEVG--EEDMVEGNDYE----EFGAFGGYG
ALTSFDIRI--LRAFGSLG-----------------------------PGFRILANEPWE
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---S----------NQA-ARAA--------------------ATAARATYNQV---VANH
H------------------------------------------------PVAT-------
------HQASGGDTQPMTSAAQ--AP--------------------AATPETSIASPHSS
------QMLVNSEMAAPGAPAR-SPQPQTSS---------------QAQ-----------
-------------EAA----------------AEGPSTACAFPQASRAGEMD-ATRPKTA
FLGQ----------------------------NDAFD-------FSQPAGV---------
----SGMAFPRPKRPAPAQEA--ATEGPSV---------AS-RGTQAASAGEGAATRPKT
T-----------------------------K-----------------------------
------------------------------------------------------------
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LAKTRWVEPQNVVAAA--------AAKA-KMATS---------IPEPESAAA---TSQQS
AE-----------------------P---------------------------------W
ARMGGKRTKKSKHLDDEY--------ESSE-EEREPPAVPPTWRASQPLLTT--------
---------A----R---------------------------------------------
----------------------------------------PQMA----------------
-----------------PRPS-----------------------------M----A----
-LRSQVPSRHVLCLP-PRNVTLL---QERANKLVK------YLMIKD-YKKIPI--KR--
------------------------------------------------------------
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SAR-LL-GKTKDT-PRLS---LLL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPFLGDLRKLITEDFVKQK-------
---------YLEYKKVPNSSP---P--EYEFLWGLRACHETSKMRVLRFIAQYQNR---D
------PREWRAHFLEAVDDAFKTMDVDMA--EEHAR----AQMRAQMNIGEEAL-----
------IGR--WSWDDIQERYLEGWCQQW---HQWRGQRQH----ARWPQHQLHHPDQKR
CQNQCQLLLLDSVRLEAALRSCGSPP------PSQSASA---ARSPTEHSRP--------
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G-SEQPA-----DLSPAGTGGGL-------------------------------------
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-------------LLEERVLGTEE------------------------------------
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EEVEEEAA----------------------------------------------------
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QSPEGACP---SPAARE-A--VPLSQPKE----------------ECPSN-EDEGAR---
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-------VFLLLKYRTKEPAT-RSEML--SRVNKEHQ-----DHFPEILSRASRC-----
----LRLLFGIE---------VEE-VDPSN---------NIYF-----------------
-------L----------------------------------GTTLGL-TYD----GT--
--------IPNTGLL-------VTFLCLILLEGDC------APEE---EVWKSLNVM---
-----GLY-DGR----EHCIYGEPRELITRVWVRE------QYVVYRQV-ANSDPARYEF
----LWGPRAHAETS--KLKVLEYLLNLKREPLP----E-VAQRHEE---EE--------
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--------------------------------------MPRGQK---SKLRAREKR-QET
-HG-----QPQGL-----------------------------------------------
-TG-------------PQVTAEKQ------------------------------------
-----------------------------------------------------------E
-ESH-----------------------SSSSSSH-----D---------------CLGTR
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S--PTGSPDAVVSCLKSDVAA----KGQDEKS------------PSTSPDASISQESQ-G
ASPTGSPDAGVSC---------SKS--------EVAVKGQDENSPSTSPDASI-----SQ
ESQGASPTG---FPDAGIS----GSKYDVAA---------------KGQ---DEESV---
-----------------------------RA-SQKAIIFKRLSQDPLKRKACALV-----
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----LAVAFGVE---------LKE-MDSSG---------ESYT-----------------
-------L----------------------------------VSKLGL-SSE----GILN
----DAKGLRKSGLL-------MSVLGVIFMKGNR------ATEE---EVWEFLSCL---
-----GIY-AGM----THPIYGDPQKLITEDLVQD------KYVVYRQV-RNSDPPRYEF
----LWGPRAHAETT--KMRVLRVLAKSNNTSPG----L-YPHLYED---ALMDEVERAL
RLRA--------------------------------------------------------
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RSIS-P-------------------------PGH----------------MLQKTR---S
R--------------------------------------------------SHPGA----
-------QLW----------------------------SPSDCCP---------------
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------------------TPGTPSPSF--RQ-IQATSAPELWTQKQLELKVAELV-----
-------QFLLIKDQRKIPIK-QSGIM--KHVVRDYK-----NIFPDLLKLAAER-----
----LHYVFGYK---------LVE-LDPKS---------NAYI-----------------
-------L----------------------------------INALEPVGKD----GELR
----GYQRTPTTGLL-------MIILGLILMNGHS------IPEN---DVWCFLRRL---
-----GVY-PTK----KHSVFGYPKKLITEDFVKQ------RYLEYRRI-PHTDPVDCEL
----QWGPRANLETS--KMKVLKFVAKIHNQDPK----D-WPTQYCE---ALADEQRRVR
PEPN-GPALTS-------------------------------------------------
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------------------------------------------------------QDP---
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---DG-HSMPKSGLL-------VTVLGVIFLQGNP------VPEK---EIWEVLSVM---
-----GMY-PGR----EHFSYGEPWKLLTRDWERE------KYLL---------------
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--------------------------------------MPRPR-----------------
-----------------KRR-RCMVE-G----------------QPEA----QSV-AVT-
-------------MEEDSSSSS--------------------------------------
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------------------------------STYSSSFPSSFS------------------
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---STSSSYALT----SGN--SEEG-----------------------------------
---------CA--------------------------------------ASRA---SSPS
HSPPGAGS---SCTARI-S--SPRSQVSA-------------------DS-EGEESP---
------------G------SLQALP------------CGTSLSTGEIDVKVDELV-----
-------KYLLLKYLMQEPVS-KAEIL--SNIIRNYQ-----DHFAVIFREALEC-----
----MQLVFGLE---------LKE-IDPAS---------HTYI-----------------
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MT-DV-QGIPKTGLL-------IMVLSIVFMEGNC------VSED---MVWSILNNI---
-----GLY-AGN----EHFIYGEPRKLITDNFVQE------GYLEYRHV-PGSHPPSYEF
----LWGPRAYAETT--KMKILTFLTSINGSDPR----S-FPVWYAE---ALRDEEQQE-
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--------------------------------------------------MLPKPE---T
E--------------------------------------------------GLPIL----
-------QTE----------------------------GENS-GLDGETQTLT-----A-
-SQE-------------------QPQGDIGA---------------VREE-G--------
----------------AAHPALTPKAA--RA-LAAKTLARRRVRRHVDQTVAELV-----
-------QFLLVKDQ-KSPIT-RSEVV--KHVIGDLK-----DLFPEIIARASES-----
----LRHVFGSE---------LKK-LDCKH---------HTYI-----------------
-------L----------------------------------INKLKPLEEE----ED--
-----LGDGPRLGLM--------MILGLIYMKGNS------AREA---QVSEMLRLL---
-----RVR-PSK----YHFFSGYPKRLIIDLLYKL------RYLSNRRM-PHTNPPECEF
----S-GPRSNLETS--KVKVLGFLPKLHKKEPH----H-RPVQYRE---ALADDADRAR
DEAT-MRART--------------RARASARAG---------------------------
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------------------MSQ--LSKNLGDSSPPAEAPKPP-------------------
----------VYSRPTVLMRAP-----PASSRAPPVPWDPPPIDLQA-SLAAWQAPQPAW
EAPQGQLPAPV---VPMTQPPALGGPIVPAPPLGGPMGKPPT------------------
---------------PGVLMVHP-PPPGAPMAQPPTPGVLMVHPSAPGAPMAHPPP-PGT
PMSHPP-------------------------PPGTPMAH---------------------
-----P---------P------------------PPGTPM----A-------HPPPPGTP
------------------------MAHP--PPPGTPMVHPPPPGTPMVHPPPPGTPMAHP
PPPGTP--MA-------------------QPPPPGTPMAQP---PAPGVLMAQPLTPGVL
MVQPA-------------APGAPMVQPP----PAAVM-------------------TQPP
PSGAPMAKPPGPGVLMIHPPGARAPMTQPPASG---------------APMAQPAAPPAQ
PMAPPAQPMASWAPQAQPLILQIQSQVI----R-------APPQV---P-----------
-------Q---GPQAPPAQLATPPGWQATSPGWQATPQGWQATPLTWQTTQVTWQAPA--
----------IAWQVPPPV-RQGPPPIRP-------------GPPPIRPGPPPVR---QA
PPVIRQ---APPVIRQAPP-VIRQAPPV-------IRQAPPVIRQAPPVIRQAPPVIRQA
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QARLPAPQVQA------------APQVPTAPPATQ-------VPAAPPAGPQVPQP---V
L--PAPLSAP----------------------------------------LSA-------
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------------------------------------------------------------
---------IPTSMEFQEVQQ-TQ-AL--AWQAQKAP-----THFWQPLPAQEAQRQ---
----APPMVQLE-------QPFQGAPPSQKAVQIQL-PPQQAQAS--GPQAELPTLQLQP
SWQTPPAVLQAQPGPPLAAANFPLGSAKSLMTP-SGESRASSIDRRGSS-KE----RRTS
SK--ERRAPSKDRM----------IFAATFCAPKA----VSAARAHLPATWKNLPATPET
FAPSSSVF-PAT----SQFQPASLNAFKGPSAASE----TPKSLPYAL---QDPFACVEA
LPAVPWVPQPNMNASKASQAVPTLLM-ATAAAPQ----A-TATT-QE---ASKTSVEMPR
RS-----------------------GKA--------------------------------
--TRK-----KKHLEAQE-DSRGHTLA-------------------------------FH
--D-WQGP----RPWENLN--LSDW--EVQSPVQ-V--LGDWEHPNTPRGLSGWEGPSTS
-RI---------------LSG---WEGPSTSWALSAWEGPSTSR-A--------------
---------LGLS---------------ESPGSPLPLVVSEVA-------------G---
VSPGSSATQDNSKVE-AQSLSPL---DERANALVQ------FLLVKD-QAKVPV--QR--
------------------------------------------------------------
----SEM---VKAIIRESKDECLGIINRANSKLECAFGYQLKEIDAKNHAYI-IINKLGY
HAGDLV-ASCLDR-PKFG---LLM----------VVLSL----------IF--------M
-KGNC----V-R--EDLIFNFLFKLGLD--VRETNGLFGNTKKLITEVFVRQK-------
---------YLEYRRIPYTEP---A--EYEFLWGPRAFLETSKMLVLRFLAKLHKK---D
------PRCWPFHYLEALAECEWEDTDEDE-PDS--T--DSA-------RGP--------
---TSRPPPR--------------------------------------------------
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-------QFLLVKDQKKIPIK-RADIL--KHVIKDYK-----DIFPEILKRANNI-----
----FQQVFGLE---------LAE-VDPKN---------HSYI-----------------
-------L----------------------------------ISKLPPLQDD-----GMK
----EDENTPKMGLL-------IIILSLIYMKGNV------VKDS---VVWEMLRRL---
-----QVECSGR----KHKIFGDVKKLVTEEFVKQ------KYLEYIRL-PHTDPLEHEF
----RWGSRAAKELS--KRQILQFVAKMQKKNPK----T-WMSQYNE---AEAEASGTGR
------H-----------------------------------------------------
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------------------MSQ--LSTNLGDSSPPE-SPVPA-------------------
----------VHSRPTVLMRAP-----PASSRAPPVPWDPPPVDLQA-PMAAWQAPQPAW
EAPEGQLPAPV---AQLAQPPGLGAPMVQAPPLGGGMAKPPT------------------
---------------PGVLMVHQ-PPPGAPMAQSSTPGVLMLHPSVTGAPL---------
--AHPP-------------------------PPGTPMTH---------------------
-----P-PGTSMAHPPPPP-----------PPPPPPGTPM----T-------HPPPPGTP
------------------------MGHH--PPPGNPMTHP-PPGNPMVHPLPHGAPMVHG
GPHGTP--MP-------------------HVPITGTPIAQQ---PTPGVLMAQQLTPGVL
MVQSP-------------APGAPMVQPP---PQAALM-------------------TQPA
PSLTPMAKPPGPGVVMIHPPGARGPIIQTPVSG---------------APMAQTVLP---
----PGQPLATWAPQGQPLILQIQSQVI----R-------APPQV---P-----------
-------S---VPQVPQVQLATPPGWQATTPNWQVTPQGWPATPLTWQATQVTWQAPT--
----------IAWQATQPV-RQGHSTIRT-------------GHTPIRPGPAP-------
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L--PAQLSIP----------------------------------------IPVP------
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PVPQELPVPQEIPVPQE--------------------------------------IP---
----------VSQEIPVPQELPVPQE------LPIPQELPVPQELPVPQELPVPQELPVP
-QELPVPQELPVPLEFQEVQQ-AQ-AV--GWRAPKVP-----THFWQPVSAQEAQEQ---
----ATQIAHVE-----QQQPFQGAPASSKAPQTQL-PPHQAQAT--GLQAELPSVQLQP
SWQGPLPMLQAQPGASATLANYPRGSSRSRMA-PSGEPGPSSLEPRGPP-RE----RRAP
AR--DKKGPPKERM----------FIGATFCAPRG----ASASRAYVPTAWKNLPATSET
FPATSRAF-PST----SHFQPASSNAFRGPSDASE----SPKSLPFAL---QDPYACVEA
LPAVPWVPYPDGNASSACKSVPAILM-VTAAAPQ----A-SATA-AE---ASKS-SEPPR
RP-----------------------GKA--------------------------------
--TRK-----KKHLEPKE-DNCGHRLS-------------------------------SH
--D-WRGP----RTWGNPS--HSDW--EIQRAMQ-L--LGDRESLYTPQGLNDWGCPNTS
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------------------------------------------------------------
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PQCNLL-ASYFER-PKFS---LLM----------VVLSL----------IF--------M
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---------YLEYRQIPFTEP---A--EYELLWGPRAFLETNRVHILRFLAALYEN---Q
------PQIWSCQYLDSLAELEYKDANAA--ANESHDSDDDS-------HDP--------
---TSSPHPH--------------------------------------------------
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---------------------------------------MDRRNDYGYRVPPFQ--G---
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EHSV-LLMHTLL-------AATK--DSLAVDPPVVNRPKK-------------SKTKKAP
IKAI----------TKV-APA--APPVPTANEIATNKPKITLQALNLPVITQISQASPT-
T------------------------------------------------EVTN-------
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QNIHA---SIANESASSQTL-ITSIKPKKAS---------------KAK-----------
-------------KAA----------------NKAIASAPEVSLAPTATHTA-TTQGQIT
-NETASIHTTAASIRTKKASKARKIIA--KVINTDTE-------HIQAANV---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------TETAT
RQIEA--------------------S---------------------------------V
IAIRPKKSKGKKAASRGP---------N------------SVSEISEALLATQMVTNQAL
AATLRVKRGS----RARKA----STKARATESQT----PNADQGAQAKMASAQ-TNVSAL
ETQ------------VA------------AAVQALADDYLAQL----SLEPTTRTRGKRN
RK-----------------------------------------------SKHLNGDERS-
GNNYRRIPWGRRPAP-PRDVAIL---QERANKLVK------YLLVKD-QTKIPI--KR--
------------------------------------------------------------
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SAG-IL-GTTKDT-PKLG---LLM----------VILSV----------IF--------M
-NGNK----A-S--EAVIWEVLRKLGLH--PGVRHSLFGEVRKLITDEFVKQK-------
---------YLEYKRVPNSRP---P--EYEFFWGLRSYHETSKMKVLKFACKVQKK---D
------PKDWAVQYREAVEMEVQAAAVAVA--EAEAR----AEARAQMGIGEEAV-----
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VNFSRGAGTRAGFSDGASISFNGAPSS--S----G-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------GPGITFGGAPSSSASFSNTASISFGGTLSTSS----------------
--------------------SFS------------------S----------------AA
SISFGGAPSTSTSFSSEASISFGGTPCTSASFSGGVSSSFSGPLN--TSATFSGAASSGF
GG------------------TL-STTAGFSSVLSTSTSFGSAPTTNTVFSSALSTSTGFG
GTLSTSVCFGGSPSSSGSFGGTLSTSICFGGSPCTSTGFGG----TLSTSVSFGGPSSTS
ANCGGTLSTSICFDGSPSAG-AGFGGALNTSASFGSALNTS-------------------
-------------------------------------------------AGFGGAMSTSA
DFGSTLSTSVCFGGSPGTSVSFGSALNTSAGFGGAVSTSTDFGG----------------
------------------------------------------------------------
-----TLSTSVC------------------------------------------------
----------------------FGGSPSTSAGFSGALNTNASFGCAISTSAGFSGAVGTS
AGFSGVPSTNPGFGGAFNTSAGFGGALSTTTDFGGTPNNSIGFGAAPSTSVSFGGAHSTS
LCFGGAPSTSLCFGSASNTNLCFGGPPSTSACFSGATSPSFGDGPSTSTGFSFGNGLSTS
AGFGGGLNTSAGFGGGLGTSAGFSGD------------------------------LSTS
SGFDGGLGTSAGFSGGPGTSTGFGGGLGTSAGFSGGLGTGAGFGGGLVTSDGFGGGLGTN
ASFGSTLGTGAGFSGGLSTSDGFGSRPNASFDRGLSTIIGFGSGSNTSTGFIGEPSTSTG
FHSGPSSIVGFSGGPSTGVGFCSGPSI-SGFSGGPSTGAGFG------------------
------------------------------------------------------------
-------GGPNTGAGFGGG-PSTSAGFGSGATSLGACGFSYG

------------------------------------------------------------
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--------------------------------------------------------MAE-
----------------------------------------------------------GS
YS-----V-Q-------SANSSVEDMDEGSHQVR--EEEMVGGNDYE----EFGAFGGYG
TLTSFDIHL--LRAFDTLG-----------------------------SGFHILSNEPWE
LENP-VLAQTLV-------EALQ--LDPDTLANETEARAA-------------NVARSAA
---S----------NRA-ARAA--------------------ATAARRSFTQV---VANH
L-------------------------------------------------IPP-------
------LPATGDSAQPMTYAE---AQ--------------------GATPEAILASPQTS
------QVSVASEMAAPGAPTI-STQSQTAT---------------PDHQ-A--------
---------------------------------AGPGTACAFCPAPSASETD-ATRPQAA
FLGQ----------------------------NDVFD-------FTQPAGV---------
----SGTAFTRPKRPAPAQEA--ATEAPSA---------AS-GMSQAVPAKD--------
G-----------------------------R-----------------------------
------------------------------------------------------------
--------------------------------------------------------SGKA
VAKTRWVEPPNVGATA--------AANT-KMATS---------IPEPEGAAA---TAQHS
GE-----------------------P---------------------------------W
ARMGGKRTKKSKHLDDEY--------ESSE-EEREPPAVPATWRTSQQPPVT--------
---------A----R---------------------------------------------
----------------------------------------AQVA----------------
-----------------PRPP-----------------------------M----P----
-LRSQIPSRHVLCLP-PRNVTLL---QERANKLVK------YLMIKD-YKKIPI--KR--
------------------------------------------------------------
----SDM---VKDVIREYDEHFPEIIERATYTLEKKFGIHLKEIDKEEHLYI-LVCTRDS
SAR-LL-GKTKDT-PRLS---LLL----------VILGI----------VF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPFLGDLRKLITDDFVKQK-------
---------YLEYKKIPSSNP---P--EYEFLWGLRACHETSKMRVLRFIAQNQNR---D
------PREWKAHFLEAVDDAFKTMDMDMA--EEHAR----AQMRAQMNIGDEAL-----
------IGR--WSWDDIQAELLT-WDEDGDFGDAWA-RIPF----AFWARYHQYILNSSR
TNRRA------TWRAGVSSGTNPGASTSILDGPSTS-ST---IRTRNAARAG--------
----ASFFSWIQ------------------------------------------------
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------------------------------------------------------------
------------------MSQ--LSTNLGDSSPPE-SPVPA-------------------
----------VHSRPTVLMRAP-----PASSRAPPVPWDPPPVDLQA-PMAAWQAPQPAW
EAPEGQLPAPV---AQLAQPPGLGAPMVQAPPLGGGMAKPPT------------------
---------------PGVLMVHQ-PPPGAPMAQSSTPGVLMLHPSVTGAPL---------
--AHPP-------------------------PPGTPMTH---------------------
-----P-PGTSMAHPPPPPPP--------PPPPPPPGTPM----T-------HPPPPGTP
------------------------MGHH--PPPGNPMTHP-PPGNPMVHPLTHGAPMVHG
GPHGTP--MP-------------------HVPITGTPIAQQ---PTPGVLMAQQLTPGVL
MVQPP-------------APGAPMVQPP---PQAALM-------------------TQPA
PSITPMAKPPGPGVVMIHPPGARGPIIQTPVSG---------------APMAQTVLP---
----PGQPLATWAPQGQPLILQIQSQVI----R-------APPQV---P-----------
-------S---VPQAPQVQLATPPGWQATTPNWQVTPQGWPATPLTWQATQVTWQAPT--
----------IAWQATQPG-RQGHSTIRT-------------GHTPIRPGPAP-------
------------------------------------------------LLRQIPPMIRQI
-QP---------V-----------------------------------------------
--------MRQAPPLIRQV---PI------------------------------------
-----------------------------------------------------------R
--------------PAPHGIASQPQLWQVLPPPP-----P---------------LRQAP
QARLLLPRVPG------------TGQVSTVPPVAQ-------IHLVPQSGPQVPQT---V
L--PAQLSIP----------------------------------------IPVP------
-------QAAAQSAP-------RTVH--CPPIIWQAPKGQAPVPQEL----PV---PQEL
PVPQELPVPQEVPVPQE--------------------------------------IP---
----------VPQEIPVPQELPVPQE------LPVPQELPVPQELPVPQELPVPQELPVP
-QELPVPQELPVPLEFQEVQQ-AQ-AV--GWRAPKVP-----PHFWQPVSAQEAQEQ---
----ATQIAHVE-----QQQPFQGAPASSKALQTQL-PTHQAQAS--GLQAELPSVQLQP
SWQGPLPMLQAQPGASATLANFPRGSTRSRMA-PSGEPGPSSLEPRGPP-RE----RRAP
AR--DKKGPPKERM----------FIGATFCAPRG----ASASRAYVPTAWKNLPATSET
FPATSRVF-PST----SHFQPASSNAFRGPSAASE----SPKSLPFAL---QDPYACVEA
LPAVPWVPYPDGNASSACKSVPAILM-VAAAAPQ----A-SATA-AE---ASKS-SEPPR
RP-----------------------GKA--------------------------------
--TRK-----KKHLEPKE-DNCGHRLS-------------------------------SR
--D-WRGP----RTWGNPS--HSDW--EIQRAMQ-L--LGDRESLYTPQGLNDWGCPNTS
-RM---------------PRS---LEGP------------STSR-D--------------
---------QEFC---------------GDSGGSQTWMASEVP-------------S---
VSRGSSAAQEDPDRE-SQPLSPL---DERANALVQ------FLLVKD-QAKVPV--QL--
------------------------------------------------------------
----SEM---VNVVIREYKDDSLDIINRANTKLECTFGCQLKEVDTKTHTYI-IVNKMAY
PQCNLL-ASYLER-PKFS---LLM----------VVLSL----------IF--------M
-KGYC----I-R--ENLLFSFLFQLGLD--VQETSGLFRITKKLITSVFVRHR-------
---------YLEYRQIPFTEP---A--EYELLWGPRAFLETNRVHILRFLAALYEN---Q
------PQIWSCQYLDSLAELEYKDANAA--AEESHDSDDDA-------HDP--------
---TSSPHPH--------------------------------------------------
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---------PLT----SGT--PEEV---P---------------------ATG-------
----------A--------------------------------------LSAC-------
QGSQGVCF---SSAATT-A--SLLSQSDE----------------N-IRS-QEEEGP---
------------S------IAEAPP------------DPQFLLSHELNQKVTELV-----
-------QFLCVKYVTKESTP-KA------SVIREHK-----DNFPVIFSKVCEC-----
----MEVVSGIE---------VKE-VDPTS---------HSYD-----------------
-------L----------------------------------VKSLNL-SYD----KRLS
---DD-RGMPKTSLL-------ILLLGMTFMEGNC------APKE---KIWEVLNMM---
-----GLY-AGQ----KDSIYGESSKLINNDLMKE------QYLDYQQL---------SF
----LWGPRAYAETS--KMKVLEF------------------------------------
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---------------------------------------MAQKMDCGAGLLGFQSPDA--
--CRAVCHPLPQPPASTLPLSAFPT-LC----------------CCTPLRASLAPAEASV
EDSA-LLMQTLM-------EAIQ--IS-EAPPTNQA--TA--------------------
------------------------------------------A-----ASPQSSQPPTA-
N------------------------------------------------EMAD-------
------IQVSAAAARPKS------------------------------------------
-----------------------------AF---------------KVQ-----------
-------------NAT----------------TKGPNGVYDFSQAHNAKDVP-NTQPKAA
F-------------------KSQNATP--KGPNAAYD-------FSQAATT---------
----GELAANKSEMAFKAQNAT-TKVGPNA---------T-YNFSQSLNANDLANSRPKT
------------------------------------------------------------
----------------------------------------------PFKAWNDTTKSPTA
-------------------------------DTQT-----------QNV-----------
----NQA---KMATSQ--------ADVETD--PG---------ISEPDGATAQTSADGSQ
AQNLE--------------------S---------------------------------R
TIIRGKRTRKINNLNV---------EENSSGDQRRAPLATGTWRSAPVPVTT-QNPPGAP
PNVLWQTPLA----WQNPS----GWQNQTARQTP----P-ARQSPPARQTPPAWQNPVAW
QNPVIWPNPVIWQNPVIWPNPI-VWPGPVVWPNPLTWQNPPGWQTPPGWQTPPGWQGPPD
WQG---PPDWPLPPDW-PLPP-DWPLP-TDWPLPPDWIPADWPIPPDWQNLRPSPNLRP-
-SPNSRASQNPSAAQ-PRDVALL---QERANKLVK------YLMLKD-YTKVPI--KR--
------------------------------------------------------------
----SEM---LRDIIREYTDVYPEIIERACFVLEKKFGIQLKEIDKEEHLYI-LISTPE-
SLAGIL-GTTKDT-PKLG---LLL----------VILGV----------IF--------M
-NGNR----A-S--EGEW--------LD--LQVRHPLLGDLRKLLTYEFVKQK-------
---------YLDYRRVPNSNP---P--EYEFLWGLRSYHETSKMKVLRFIAEVQKR---D
------PRDWTAQFMEAADEALDALDAAAA--EAEAR----AEARTRMGIGDEAV-----
------SGP--WSWDDIEFELLT-WDEEGDFGDPWS-RIPF----TFWARYHQNARSRFP
QTFAG---------------------P--IIGPGGTASA------NFAANFGAIGF----
--------FWVE------------------------------------------------
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--------------------------------------MPRGQK---SKVRAHEKC-HQA
-RS-----ETQVL-----------------------------------------------
-HD--------------QATTSRG------------------------------------
-----------------------------------------------------------E
-ETT-------------------------SSSLP-----D---------------SESPP
SSSS-A-------------------------AGT----------------PKGRQG---A
Q--GTTSAAAGAIPKRSGGGGT--------------------------------------
------------------------------------------------------------
--------ARSRS--------------GA-------------------------------
-----------------------------------SAAAASSHRDLLTKKAQMLV-----
-------QHMLYKYKMRELIK-RSEML--KAIGRRYM-----KQFPEILSRASEH-----
----MEIVFGLV---------LKE-VRPNS---------HCYT-----------------
-------L----------------------------------VSNLDL-SDS----ESMR
----GDLGLPKNGLL-------MPLLSFIYLNGPR------ISEE---HIWKLLNIL---
-----GIY-DGR----RHFIFGDTRKLITEDLVQE------EYLEYNQV-PGSDPPRYEF
----LWGPKALTETN--KNKVMEFWAKVNDTVPD----A-CLAQYEE---SFRQEVESTG
ARAAA-RVGTSAS----------------GMAG---------------------------
-----------------------TSA----------------------------------
-S--------------------GMAATSAS------------------------------
------------------------------------------------------------
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--------------------------------------MPRGQK---SKLRAREKR-RKA
-RE-----ETQGL-----------------------------------------------
-NV-------------PQVTEAKE------------------------------------
-----------------------------------------------------------E
-EAP-------------------------CCSSS-----V---------------SGGAA
SSSP-A-------------------------AGI----------------PQKPQR---A
P---TTAAAAAA------------------------------------------------
------------------------------------------------------------
----------------GVS----STKSKKGA---------------KS-Q-GE-KNA---
-----------------------------SS-SQASTSTESSSEDPLTRKAGMLV-----
-------QFLLYKYKIKESVT-KGEML--KIVGKRFR-----EHFPEILKKASER-----
----LSLVFGLE---------LNK-VKPNG---------HTYT-----------------
-------F----------------------------------NSKV----DE---ECL-L
----STWDFPRSGLL-------MPLLGVIFLNGNS------AAEE---EIWEFLNMM---
-----GVY-DGE----EHLVFGEPRKLITQDLVEE------KYLEYKQV-PNSDPPRYRF
----LWGPRAYAETS--KMKVLEFLAKVNGTTPS----A-FPAHYEE---ALRDEGKAGV
------------------------------------------------------------
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-----------------------M----------VLLSI----------IF--------M
-NGNW----S-S--EAVIWEVLRKLGLR--PGVRHSLFGEIRKLIPDEFVKQK-------
---------YLEYKRVPNSRS---P--EYE-FWGLHSYHETSKMKVLKFSCKMQKK---D
------IKDWA-----AVEMEVQAAAVAVA--EAEARAEARAEARSQMRIGEEAV-----
------AGP--WNWDDMAIDCLT-KEELGGSSSTST-DFGG----TLSTSICFGGSSSTG
ASFGGSFSTSAGFSSAVSTSFSSGPSS--SAGFGGGLRNGAG--------FSGGA----T
RLGACS---F---SYG--------------------------------------------
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--------------------------------------MPRGHK---SRLRAREKR-HEA
-RG-----DTHDV-----------------------------------------------
-KG-------------AQATAAEE------------------------------------
-----------------------------------------------------------A
-GSP-------------------------SS--P-----P---------------SEGSR
ESSP-A-------------------------ARI----------------PWESLR---V
------------------------------------------------------------
------------------------------------------------------------
-----PPIT---TVVSATW----FPRATAGA---------------QA-G-GE----G--
----------GS-----------------RS-SEASGPTGKCYKDLLNRKEVLLL-----
-------QLLLKKYKMKEPIK-KAEMM--KIVNKRYK-----ELFPELLRRVSEH-----
----MEIVFGLD---------LKQ-ADSKG---------ETYT-----------------
-------L----------------------------------VSTLEF-TNE----EIMV
----GGRGLPKNGLL-------MPLLGMIYASGKR------ATEE---AVWKYLNEL---
-----GIY-DGE----RHYIYGEPRKLITKDLVRE------KYLEYQQV-PNSDPPRYEF
----LWGPKACTEAN--KKKVLTFLAKVSHTDPY----F-FQALCEE---AWRNDEERAA
GR----------------------------------------------------------
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---------------------------------------------------METQFRRGG
LGCSPASIKRKKKREDSG--DLGLQVSTMFSEDDFQST---ERAPYGPQL----------
---------QWSQDLPRVQVFRE----------QANLE---DRSPR-RTQRITGGEQV--
-----------------LWGPITQIFPTVRPADLTRVIMPLEQ-----------------
-----------------RSQ-HCKPE-E----------------GLQA----QEE-DLG-
-------------LVG-AQALQAE------------------------------------
-----------------------------------------------------------E
Q-E---------------------------------------------------------
------------------------------------------------------------
---AAFFSSTLN----VGT--LEE------------------------------------
---------LP--------------------------------------AAES---PSPP
QSPQEESF---SPTAMD-A--IFGSLSDE----------------GSSS--QEKEGP---
------------S------TSPDLI------------DPESFSQDILHDKIIDLV-----
-------HLLLHKYRVKGLIT-KAEML--GSVIKNYE-----DYFPEIFREASVC-----
----MQLLFGID---------VKE-VDPTS---------HSYV-----------------
-------L----------------------------------VTSLSL-SYD----GIQC
---NE-QSMPKSGLL-------IIVLGVIFMEGNC------IPEE---VMWEVLSIM---
-----GVY-AGR----QHFLFGEPKRLLTQNWVQE------KYLVYRQV-PGTDPACYEF
----LWGPRAHAETS--KMKVLEYIANANGRDPT----S-YPSLYED---ALREEGEGV-
------------------------------------------------------------
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--------------------------------------MNPTE-----------------
-----------------NSQSLFNLP-A----------------SPQA----QRE-ERG-
-------------LESAQFP----------------------------------------
------------------------------------------------------------
--------------------------------------IAEG------------------
------------------------------------------------------------
---NQVAATAST----SGE--V--------------------------------------
----------S--------------------------------------GGGT---LSSP
QSAERASS---PPAAMG-G--ES----------------------------SGEASG---
------------N------QAGEVA------------EPEYPSQGVLNEKIVDLV-----
-------RFLLIKFRRMELAT-KSEMM--TRAMRDYE-----EYYAVIFSKASEC-----
----MRLIFGIE---------MME-VDPFV---------HSYF-----------------
-------L----------------------------------YPALGI-TYD----GM--
LH-GV-VGVPKTGLV-------IIVLCIIFIEDNC------VSEE---VFWDVLNSL---
-----GLY-AGM----DHFIFGEPRSLITEDFVQE------GYVEYRQV-PNSCPPRYEF
----LWGPRAYAETT--KMKVLEFYASIVKQDPR----S-YPEKYAE---ALREQQERA-
------------------------------------------------------------
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--------------------------------------MPRGQK---SKLRAREKR-RLA
-RS-----ENQSL-----------------------------------------------
-EG-------------AQAIAAA-------------------------------------
------------------------------------------------------------
-EEA-------------------------DSVYS-----L---------------FEGML
QNMS-V------------------------AETES-------P-------PQSPQR---A
P--YTSNTTA-A------------------------------------------------
------------------------------------------------------------
-----------------FS----GATPDEGV---------------RS-P-TV-ESL---
------------------------------N-F--SQGTEGIRKDPLNKKVVLLV-----
-------QFLLQKYQKKEPIT-KADML--KYVIKKYK-----GHFDEILKRTSEH-----
----LELTFGVD---------LKE-VDPIM---------HCYT-----------------
-------L----------------------------------VSKLNL-TSD----GMM-
----SEESMPKTGLL-------MIVLSVIFMKGNC------ALEE---EIWEVLNMM---
-----GVY-ADR----RHFIYGEPRKIINEDLVQL------KYLECQQV-PNSDPPRYEF
----LWGPRAHAETT--KMKVLEFLAKIHDAVPS----D-FPLWYEE---ALREEEERAK
AR-VAALARTS-AM----------------------------------------------
----------------------------------------------------------FS
--------------------KRNR-------------------------MEKS-SLAHSF
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--------------------------------------MSLEQ-----------------
-----------------RSL-HCKPE-E----------------ALEA----QQE-ALG-
-------------LVCVQA-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---AASSSSPLV----LGT--LEE------------------------------------
---------VP--------------------------------------TAGS---TDPP
QSPQGASA---FPTTIN-F--THQRQPNE----------------GSSN--HEEEGP---
------------S------TSRIL---------------ESLFRAVLTKKVADLV-----
-------HFLLLKYRAKEPVT-KAEML--ESVIKNYK-----RCFPVIFGKASES-----
----LQLVFGID---------VKD-ADPTG---------HSYV-----------------
-------L----------------------------------VTCLGL-SYD----GLLG
---DN-LIMPKTGFL-------IIVLVMIVMKGGR------ATEE---EIWEELSVM---
-----EVY-DGR----EHSAYGEPRKLLTQDLVQE------KYLEYRQV-PDSDPARYEF
----LWGPRALAETS--YVKVLEYVIKVSARVRF----F-FPSPREA---ALRRE-----
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--------------------------------------MPRGQK---SKLRAREKR-RQA
-RQARAKTQTQVL-----------------------------------------------
-EG-------------AEAIAAE-------------------------------------
------------------------------------------------------------
EGEL-------------------------SSAHP-----V---------------LEDSP
QNEL-A------------------------AETPS-------T-------STEPQE---T
P--SNT--TG-A------------------------------------------------
------------------------------------------------------------
-----------------AS----GTDSNAGA---------------SK-Q-DE-ASS---
------------------------------E-S--AKALESFRRDPLNKKVVLLV-----
-------QFLLKKYQSKEPIT-KADML--RLVIKKYK-----MHFSEILRRASEH-----
----MELAFGID---------LKE-VDPIR---------HSYA-----------------
-------L----------------------------------VSKLDL-TLD----GMA-
----NEENLPKTGLL-------MIVLGVIFMKGNC------APEE---AIWEVMNMM---
-----GVY-ADK----KHLIYGEPKKVITEDLVQL------RYLEYRQV-PDSDPPRYEL
----LWGPRAHAETS--KMKVLEFLAKIYDTVPS----A-FPVWYEE---ALRDEEERAQ
AR-AAARARIAM------------------------------------------------
-----------------------------------------------------------T
--------------------AHS--R-----------------------AVTS-SSSHIK
------------------------------------------------------------
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--------------------------------------MPLEQ-----------------
-----------------RSQ-HCKPE-E----------------GLEA----RGE-ALG-
-------------LVGAQAPATEE------------------------------------
-----------------------------------------------------------Q
E-T---------------------------------------------------------
------------------------------------------------------------
----ASSSSIVV----EVT--RGR------------------------------------
---------CL--------------------------------------LLSH-------
------------------------------------------------------------
------------------------------------------------------------
-------RVLPRVLRTREPVT-KAEML--ESVMRNCQ-----YFFPVIFSKASDS-----
----LQLVFGIE---------LME-VDLIG---------HLYI-----------------
-------F----------------------------------VTCLGL-SYD----GLLG
---DN-QIMPKTGLL-------IIVLAIIAKEGDC------APEE---KIWEELSVL---
-----EVF-EGR----QHSIFADPRKLLTQDFVQE------NYLEYQQV-PSSDPACYKF
----LWGPRALVETS--YVKGLYHMLKISRGPHF----S-YSPLHEW---ALREGEE---
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------------------------------------------------------------
------------------MSL--VSQNSRRRRRRVAK---ATA-----------------
----------H-NSSWDEMQAPNAPGFPADMPGSDVPQGPSDSQILQ-GLCAS-------
---EG-----------------PST------------SVLPT------------------
---------------SAEGPST---------FVPPTIS---EASSASGQPTV-SEG-PGT
SLLATP---------------S-EG----LSTSGPPTIS---------------------
-----KGLCTSVTLAASEGRN------TSRPPTSSEEPST---S----------------
--------------------------V-----------------------------TSVV
PTPDEGPSTS-------------------V------------------------------
--------------------TS---VP-----PTATEG------------LST---PVPP
T------PDEGPSTSMPATPGEGRSTSMLPAAS---------------DGQSIS------
------------------------------------------------------------
------------------------------------------LVPTPGKGSSTSGPPTAT
EGLSTSV---------QPTAGEGPSTSV--------------------------------
---------------------------------------------------------TSV
----------PPT----------------------------------------------P
GEGLSTS---------VPPTAT--------------------------------------
-----------------------------------------------------------E
GLST--------------------------SVPP-----T---------------PGEGP
ST-SVLP-TPG------E-GRS-TSVPPT-ASD-GS--D---T-SVP---PT-PGE----
G--PSTLVQP----------------TASDRP--------------GSSVLPNP------
---GEGPSTLFSSSA-----SVDRNPSKCS-IVLPSPRVTKA------------------
----------------S------VDSDSEGP---------------K-------------
-------GAEGPIEFEVLRDCESPNSITIMGLSTSRVAITLKPQDPMEQNVAELL-----
-------QFLLVKDQSKYPIR-ESEMR--EYIVKEYR-----NQFPEILRRAAAH-----
----LECIFRFE---------LRE-LDPEA---------RTYI-----------------
-------L----------------------------------LNKLGPVPFE-----GLE
----ESPNGPKMGLL-------MMILGQIFLNGNQ------AKEA---EIWEMLWRM---
-----GVQ-RER----RLSIFGNPKRLLSVEFVWQ------RYLDYRPV-TDCKPVEYEF
----FWGPRSHLETT--KMKILKFMAKIYNKDPM----D-WPEQYNE---ALEEDAARAF
AEG---------------------------------------------------------
------------------------------------------------------------
----WQALPHFRRPFFEE----------AAAE------------------VAS-PD----
-SE---------------------------------------------------------
---------VSSY-------------------------S---------------------
---------SKYAPH-SWPESRL---ESKARKLVQ------LFLLMD-STKLPI--PK--
------------------------------------------------------------
----KGI---LYYIGRECSKVFPDLLNRAARTLNHVYGTELVVLDPRNHSYT-LYNRREM
EETEEI-VDSPNR-PGNN---FLM----------QVLSF----------IF--------I
-MGNH----A-R--ESAVWAFLRGLGVQ--SGRKHVI--------TCRYLSQR-------
---------YIDSLRVPDSDP---V--QYEFVWGPRARLETSKMKALRYVARIHRK---E
------PQDWPQQYREAMEDEANRADVGHR-QF----------FVHNFR-----------
------------------------------------------------------------
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----------------------------------MNRRNGHGYRMPAFQSRHPNGDERS-
GINYRRIPWGRRLPP-PRDVAIL---QERANKLVK------YLLVKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LKDVIQEYDEYFPEIIERASYALEKMFRVNLKEIDKQSSLYI-LISTRES
SAG-IL-GSTKDT-PKLG---LLM----------VILSV----------IF--------M
-NGNK----A-S--EAVIWEVLRKLGLH--PGVRHSLFGEVRKLITDEFVKQK-------
---------YLEYKRVPNSRP---P--EYEFFWGLRSYHETSKMKVLKFACKVQKK---D
------PKDWAAQYREAVEMEVQAAAVAVA--EAEAR----AE-----------------
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-------------------------------------MMPLS-Q----------------
-----------------KSQ-PGKNE-Q----------------GLQA----QKE-AQG-
-------------LVGAQVPAAEK------------------------------------
-----------------------------------------------------------V
S-S---------------------------------------------------------
------------------------------------------------------------
---TASSSSALI----PST--LEAV---S---------------------AVG-------
----------T--------------------------------------PDAP-------
KSPQKTCS---SSTTMK-A--TPWSQPEE----------------G-SSS-QEKNDP---
------------S------TSQFLP------------YPECLFSNMLEKKVAELV-----
-------KFLSVKYTTKEPVT-EAEML--KNVIKEYK-----DHFPGIFMKACEC-----
----MEMVFGIE---------VKK-VDPIS---------RSYV-----------------
-------L----------------------------------TKMLDL-TYD----GRLS
---D-DEGIPKTGLL-------ILILGVIFMEGNR------APEE---KIWKVLNMI---
-----GVY-AEG----KDFIYGECRKLITKDLVQE------KYLEYRQV-PNSDPPSYEF
----LWGPRAHAETS--KKKVLEFFSKVSGSEAT----A-FTSLYKE---ALRDEEERAQ
AKIANKAKFSS-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------FC-----------------------
------------------PE----------------------------------------
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--------------------------------------MPLEQ-----------------
-----------------RSQ-HCKPE-E----------------GLQA----QGE-ALG-
-------------LVGAQAPAPEE------------------------------------
-----------------------------------------------------------Q
E-T---------------------------------------------------------
------------------------------------------------------------
----ASSSSTVV----EVT--LGE------------------------------------
---------VP--------------------------------------AAES---PGPP
QSPQGAST---LRTTIS-Y--TLWSQSDE----------------DSSS--QEEEGP---
------------S------TFPDL---------------ESGFQAALSRKVAELV-----
-------HFLLLKYRAREPVT-KAEML--ESVMRNCQ-----YFFPVIFSKAFES-----
----LQLVFVIE---------LME-VDPVG---------HLYI-----------------
-------F----------------------------------VTCLGL-SYD----GLLG
---DN-QMMPKTGLL-------IIVLAIIAKEGDC------APEE---KIWEELSVL---
-----EVF-EGR----EHSIFADPRKLLTQDFVQE------NYLEYRQV-PGSDPACYEF
----LWGPRALLETS--YVKVLYHMLKISGGPHF----S-YPPLHEW---ALREGEE---
------------------------------------------------------------
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--------------------EVEE------------------------------------
-----------------------------------------------------------E
-TSS-------------------------SSSSS-----P---------------TPSNL
EEDT-T------------------------AEIPS-------S-------AQDSQT---S
S-----------------------------------------------------------
------------------------------------------------------------
-----------------------EGTSDEDS---------------SS-E-EDEETS---
-----------------------------RT-SESPLDIENLPRNPVEEKVAMLV-----
-------NFLLFKYQIKEPVT-KADML--DTVIKEYE-----DHFTEILLKASER-----
----IEMVFGLD---------VKE-VDPVS---------HCYV-----------------
-------L----------------------------------LIKLDL-TYD----GMLI
----ETEGMPKSGLL-------ILILGVIFMKGNR------ITEE---EIWEVLNTM---
-----DIY-AGR----KHFIFGEPGNLVTKELVQE------KYLEYRQL-PDSDPPRYEF
----LWGPRAHAEIS--KMKLLEFLARVHGVDPP----S-FSQQYRE---ALKEEEEKAQ
AG-ASASSGAT-AT----------------------------------------------
----------------------------------------------------------AM
--------------------ESS--S-----------------------GTSS-SCSHP-
------------------------------------------------------------
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--------------------------------------MSRSR-----------------
-----------------KRR-CFMLE-E----------------GSET----QDE-GQC-
-------------PSG--------------------------------------------
---------------------------------------------------RRIAVPVEE
EGSSSSSSS-----------------------CSSSFPS---------------------
---STC---------------------------------------S----------SPSS
-----------------SS----EDN----------------------------------
---------AL--------------------------------------TAGN---PVCP
DSPQGACS---SFSALA-L--ASRVQSG-------------------------EG-A---
------------G------SSQELP------------GVVVMSDRERDEKVNTLV-----
-------SFLLLKYQRKEPVT-QAEIM--GVI--NSH-----SQFSVIFSEVFEC-----
----LQLIFGLD---------FKE-VESSN---------QSYV-----------------
-------L----------------------------------VTVLGI-SYD----GL--
FS-EV-QGMPKTGLL-------VLILSIIFLQGDS------ASEE---EVWQTLNAM---
-----GIW-AGI----EHFVYGDPGKLVFEDFVQE------QYLVHQQV-PDSNPPSYEF
----LWGPRTFAETS--KMKLIEFLASISRVDPR----A-FGQRYEE---AQREEEER--
------------------------------------------------------------
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--------------------------------------MPRRHK---NKSHARGKR-HQV
-RG-----DTQEA-----------------------------------------------
-QA-------------SAAAAPKE------------------------------------
-----------------------------------------------------------E
-CP--------------------------SSPSS-----A---------------PQGSP
LSSP-A-------------------------AGD-----------------QELQG---A
M--APSSADA-G------------------------------------------------
------------------------------------------------------------
-----------------PS----CAGSDEGA---------------QG-P-EE-ESA---
-----------------------------GA-SQAAPATQSTRKDPLARKARILV-----
-------EFLLEKYTKKEPIT-QNALM--KIVSRKYR-----QHFPEILSTALER-----
----VELVFGLE---------MKE-VDRSR---------NIYT-----------------
-------L----------------------------------ISKLNL-GGN---DCP-S
----GEGGLPKSGLL-------MVLLGVVFMNGNR------ATEE---QIWEFLSML---
-----GIY-AGR----RHWIFGEPRRLITKDLVQK------EYLNYRQV-PNSDPPRYEF
----LWGRRACAETS--KMKVLEVLAKFHGRVPS----S-FPDLYDE---VLRDQAERAG
LR-GEARAPPM-AD----------------------------------------------
----------------------------------------------------------AF
--------------------APS--K-----------------------AKSR-SSSHI-
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---------------------------------------MSDT-----------------
---------------SE-SGA----------------------------GLTSFQAEASE
KDSS-SMMQTLL-------TVTQ--NVEVPETPKAS------------------KA----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------PEVSEDVKVS-------KTSGVS---------------KAT-----------
-------------EV---------------------------SKTPEAQEAP-ATQASST
-TQLTDTQVLAA----EN--ESLAADT--KKQNADPQ-------AVTMPAT---------
----ETKK-----VSC--------------------------------------------
------------------------------------------------------------
--------------------------------------------------------VA--
-------------------------------DTKV-------------------------
----N-T--KAQETEA--------AASQAPADEP---------EP--ESAAAQSQENQDT
RPKVK--------------------A---------------------------------K
KARKVKHLDGEEDGS---------------SDQSQASGTTGGRRVSKALMASMARRASRG
PIAFWARRAS----RTRLA----A------------------------------------
------------------------------------WARRALL----SLRSPKARRGKAR
RRA---------------------------------------------------------
-AKLQS-SQEPEAPP-PRDVALL---QGRANDLVK------YLLAKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LKDIIKEYTDVYPEIIERAGYSLEKVFGIQLKEIDKNDHLYI-LLSTLEP
TDAGIL-GTTKDS-PKLG---LLM----------VLLSI----------IF--------M
-NGNR----S-S--EAVIWEVLRKLGLR--PGIHHSLFGDVKKLITDEFVKQK-------
---------YLDYARVPNSNP---P--EYEFFWGLRSYYETSKMKVLKFACKVQKK---D
------PKEWAAQYREAMEADLKAAAEAAA--EAKAR----AEIRARMGIGLGSE-----
----NAAGP--CNWD-------------EADIGPWA-KARIQAGAEAKAKAQESG--SAS
TGASTST------NNSA--SA--SAST--SGGFSAGASLTATLTFGLFAGLGGAGASTSG
SSGACG-FSYK-------------------------------------------------
------------------------------------------------------------
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--------------------------------------MPRA-P----------------
-----------------KRQ-RCMPE-E----------------DLQS----QSE-TQG-
-------------LEGAQAPLAVE------------------------------------
-----------------------------------------------------------E
D-AS-----------------------SSTS-TSSSF----PSS----------------
-----------------------------------------------------------S
S-SSSSSCYPLI----PST--PEE--VSA---------------------ADE-------
----------T--------------------------------------PNPP---QSA-
---QIACS---SPSVVA-S--LPLDQSDE----------------G-FSS-QKEESP---
------------S------TLQALP------------DSESLPRSEIDEKVTDLV-----
-------QFLLFKYQTKEPIT-KAEIL--ESVIKNYE-----DHFPLLFSEASEC-----
----MLLVFGID---------VKE-VDPTG---------HSFV-----------------
-------L----------------------------------VTSLGL-TYD----GMLS
---DV-QSMPKTGIL-------ILILSIIFIEGYC------TPEE---VIWEALNMM---
-----GLY-DGM----EHLIYGEPRKLLTQDWVQE------NYLEYRQV-PGSDPARYEF
----LWGPRAHAEIR--KMSLLKFLAKVNGSDPR----S-FPLWYEE---ALKDEEERAQ
DRIATTDDTTA-------------------------------------------------
------------------------------------------------------------
-----------------------MA--------S----------------ASS----SA-
------------------------------------------------------------
---------TGS---------------------FSYP-----------------------
-------------------E----------------------------------------
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--------------------------------------MPLEQ-----------------
-----------------RSQ-HCKPE-E----------------GLEA----RGE-ARG-
-------------LVGAQAPATEE------------------------------------
-----------------------------------------------------------Q
Q-I---------------------------------------------------------
------------------------------------------------------------
----ASSSSTLV----EVT--LGE------------------------------------
---------VP--------------------------------------AADS---PSPP
HSPQGASS---FSTTIN-Y--TLWRQSDE----------------GSSN--QEEEGP---
------------R------MFPDL---------------ESEFQAAISRKMVELV-----
-------HFLLLKYRAREPVT-KAEML--ESVIRNFQ-----DFFPVIFSKASEY-----
----LQLVFGIE---------VVE-VVPIS---------HLYI-----------------
-------L----------------------------------VTCLGL-SYD----GLLG
---DN-QIMPKTGLL-------IIVLAIIAIEGDC------APEE---KIWEELSML---
-----EVF-EVG----EDSVFEHPRKLLMQDLVQE------NYLEYRQV-PGSDPACYEF
----LWGPRALIETS--YVKVLHHTLKMGGEPHI----S-YPPLHEW---ALREGEE---
------------------------------------------------------------
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RSVS-P-------------------------PGH----------------ML--------
----------------------------------------------------HPDA----
-------QLW----------------------------SSSDCCP---------------
--------GVSGE----------IARASGDP---------------DALQ-D--------
------------------PPGARSPSF--RQ-AQATSAPELWTQKQLELKVAELV-----
-------QFLLIKDQRKIPIK-QSGIM--KHVIRDYK-----NIFPDLLKLAAER-----
----LHYVFGYK---------LVE-LDPKS---------NAYI-----------------
-------L----------------------------------INALEPVDKD----SELR
----GYQRTPTTGLL-------MIILGLILMNGHS------IPEN---DVWCFLRRL---
-----GVY-PTK----KHSVFGYPKKLITEDFVRQ------RYLEYRRI-PHTDPVDCEL
----QWGPRANLETS--KMKVLKFVAKIHNQDPK----D-WPTQYCE---ALAEEQRRVR
PEPN-GPAPTS-------------------------------------------------
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----------------------------------MDRRNDYGYRTTVFQSKHPNGDERS-
GSNYRRIPWGRRPTP-PRDVAIL---QERANKLVK------YLLVKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LKDVIQEYDEYFPEIIERASYALEKMFRVNLKEIDKQSSLYI-LISTQES
SAG-IL-GTTKDT-PKLG---LLM----------VILSV----------IF--------M
-NGNK----A-S--EAVIWEVLRKLGLR--PGVRHSLFGEVRKLITDEFVKQK-------
---------YLEYKRVPNSRP---P--EYEFFWGLRSYHETSKMKVLKFACKVQKK---D
------PKDWAAQYREAVEMEVQAAAVAVA--EAEAR----AEARAQM------------
---------G-IGEE--------------------P-RYSL----GIFVHTAI-------
------------------------------------------------------------
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------------------------------SSHP-----P---------------VPGNS
KEAP-G------------------------AGTPR-------T-------PKGPQR---S
H--SSSTATA-A------------------------------------------------
------------------------------------------------------------
-----------------TS----LSKSDEGS------------------G-GQKGNA---
-----------------------------ST-SWAGPGPKNVPIDAIDKNAALLV-----
-------NFMLFKYQTKEPIT-KTDML--KSVIKEYE-----DHFVEIFQKACEY-----
----MEMIFGFD---------VKE-VDPTN---------HCYV-----------------
-------F----------------------------------LIKMGL-TYD----GMLH
----GEKGVPKTGIL-------ILILGVIFMRGNR------ATEE---EVWEVLSLT---
-----GIR-SRR----KHFIFGEPRELITKDFMKK------KYLKYRRV-ANSDPAKFEF
----LWGPRAHAEVT--KMQVLEFLAKVHGTDPS----S-FPSQYEE---ALQDEEERAR
AR-IS-------------------------------------------------------
------------------------------------------------------------
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--------------------------------------MSF-------------------
---------------HKKYL-DCKLE-K----------------KIQN----LSE-AHG-
-------------LEDVQLYRNDQ------------------------------------
-----------------------------------------------------------E
------------------------------------------------------------
------------------------------------------------------------
--MPTSSPSVLF----PGT--LEE------------------------------------
---------EV--------------------------------------DGGL---PYNP
QKPLRALL---SPRAMA-D--SPQSQLEG----------------NDRS---KEEGP---
------------R------SHQELG----------EMK-YSLPEKALFGKMVD-------
---------LVIKYRSKKPTS-EAEIQ--CRVLASYK-----DYFPIIFNQASEC-----
----LQLIFGIK---------VQE-ADPQD---------HSYV-----------------
-------A----------------------------------VTNLDF-ISD----GMGD
-P--E-QDMPKTGLL-------VMVLAVIFLEGDC------SSEE---NVWESLTLL---
-----GVK-PGK----KHSIYGEPRELLTKVWVLE------QYLEYRQV-PGSHPVHYMF
----LWGPRAHAETS--KRKVLELWVKLTAWIPD----A-SL------------------
------------------------------------------------------------
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---------------------------------------MAQKMDCGAGLLGFQNPDA--
--CRAVCHPLPQPPASTLPLSAFPT-LCDPPYSQLRDPPAVLSCYCTPLGASPAPAEASV
EDSA-LLMQTLM-------EAIQ--IS-EAPPTNQA--TA--------------------
------------------------------------------A-----ASPQSSQPPTA-
N------------------------------------------------EMAD-------
------IQVSAAAARPKS------------------------------------------
-----------------------------AF---------------KVQ-----------
-------------NAT----------------TKGPNGVYDFSQAHNAKDVP-NTQPKAA
F-------------------KSQNATP--KGPNAAYD-------FSQAATT---------
----GELAANKSEMAFKAQNAT-TKVGPNA---------T-YNFSQSLNANDLANSRPKT
------------------------------------------------------------
----------------------------------------------PFKAWNDTTKAPTA
-------------------------------DTQT-----------QNV-----------
----NQA---KMATSQ--------ADIETD--PG---------ISEPDGATAQTSADGSQ
AQNLE--------------------S---------------------------------R
TIIRGKRTRKINNLNV---------EENSSGDQRRAPLAAGTWRSAPVPVTT-QNPPGAP
PNVLWQTPLA----WQNPS----GWQNQTARQTP----P-ARQSPPARQTPPAWQNPVAW
QNPVIWPNPVIWQNPVIWPNPI-VWPGPVVWPNPLAWQNPPGWQTPPGWQTPPGWQGPPD
WQG---PPDWPLPPDW-PLPP-DWPLP-TDWPLPPDWIPADWPIPPDWQNLRPSPNLRP-
-SPNSRASQNPGAAQ-PRDVALL---QERANKLVK------YLMLKD-YTKVPI--KR--
------------------------------------------------------------
----SEM---LRDIIREYTDVYPEIIERACFVLEKKFGIQLKEIDKEEHLYI-LISTPE-
SLAGIL-GTTKDT-PKLG---LLL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPLLGDLRKLLTYEFVKQK-------
---------YLDYRRVPNSNP---P--EYEFLWGLRSYHETSKMKVLRFIAEVQKR---D
------PRDWTAQFMEAADEALDALDAAAA--EAEAR----AEARTRMGIGDEAV-----
------SGP--WSWDDIEFELLT-WDEEGDFGDPWS-RIPF----TFWARYHQNARSRFP
QTFAG---------------------P--IIGPGGTASA------NFAANFGAIGF----
--------FWVE------------------------------------------------
------------------------------------------------------------
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--------------------------------------MPRGHK---SKLRAREKR-RQA
-RG-----EPQGL-----------------------------------------------
-GA-------------AEAIAAGG------------------------------------
-----------------------------------------------------------E
-EAP-------------------------SSSSA-----V---------------SEGAS
RSAP-A-------------------------AGN----------------PRKSRR---A
R--AT-CSSAAA------------------------------------------------
------------------------------------------------------------
-----------------VS----GTRAEQGA---------------QG-Q-DG-ERP---
-----------------------------SS-SRVSRSSERSTKDPLAKKVSMLV-----
-------QFVLQKYKMKEPIT-KADML--KIVTKRYR-----EHFPEILRKTTLR-----
----MELVFGLQ---------LKE-VDPRG---------RSFE-----------------
-------L----------------------------------VSKLHL-SSD---RSQ-T
-----EDSFPKNGLL-------MPLLSVIFMNGDR------ASEE---EIWEFLNVL---
-----GLH-DGR----EHFIYGEPRKLITKNFVQE------KYLEYRLV-PDSDPPCYEF
----LWGSKAHAETS--KMKVLEFLAKVTKTVPS----T-FQSQYEE---ALKDEEERSQ
TR-VGARAGAT-AQAS--------------------------------------------
------------------------------------------------------------
--------------------SSS--Q-----------------------P----------
------------------------------------------------------------
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---------------------------------------PHGQK---SKIHAREKC-C--
----------KGL-----------------------------------------------
-LD-------------AQTTAAEE------------------------------------
------------------------------------------------------------
-EDS-------------------------SSYSP-----V---------------SGGAV
LSSP-T-------------------------AGI----------------FQKPQR---A
P--PTTTAVA--------------------------------------------------
------------------------------------------------------------
----------------AVS----CTKSKNDS---------------KR-Q-GEESKN---
------------------------------S-STVSTSIEMLHKEVVTEAMWILL-----
-------QYLVQMYKMNQPIT-KGEML--KAARKRCR-----SHFPEIFRRASEL-----
----IEQQFGLG---------LKK-ISPSG---------NTYI-----------------
-------F----------------------------------VSKVNH-TKD----ESLS
----GKWDFPKNGLL-------VPLLGVIFLNGNS------TTEE---EIWEYLNTL---
-----AVF-DGE----WDFIYGEPQKVITEDLVQE------KYLEYQQV-PNSEPPCYQF
----LWGPRAFVETS--KIKVLEFWAKVNDTIPS----T-FPSQYEE---ALRDQEERAQ
ARDT-VRP----------------------------------------------------
-----------------------------------------------------------S
--------------------TTTKV------------------------------SE---
------------------------------------------------------------
------------Y-----------------------------------------------
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-------M-E-------SETYTFEDMDEGSDEVG--EEEMVEGNDYE----EFGAFGGYG
TLTSFDIRI--LRAFGSLG-----------------------------PGLRILSNEPWE
LENP-MLARTLM-------EAFQ--LDPETLANEAAAHAV-------------NVARAAA
---S----------NRA-ARAA--------------------AAAARATYNQV---VTNR
-------------------------------------------------PVAT-------
------DQASGEDTQPMTYAAQ--AQ--------------------AATPEATLAAPHIS
------QMLVTSEMATPGAPAK-STQPQTGS---------------QAQ-----------
-------------EAA----------------TEGPSAACGFSQAPCASEMD-ATRPKTA
FLGQ----------------------------NDLFD-------FTQPAGV---------
----SGMAFSRSKRPAPAQEA--ATEGPSA---------AS-GVLQAAPAREGAATRPKT
T-----------------------------K-----------------------------
------------------------------------------------------------
--------------------------------------------------------SGKA
LAKTRWVEPQNAVTAA--------AAKT-KMATS---------IPEPEGAAA---PAQHS
AE-----------------------P---------------------------------W
VRMGGKRTKKSKHLDDEY--------ESSE-EEREPPAVPPTWRPSQPPMT---------
---------V----R---------------------------------------------
----------------------------------------AHMV----------------
-----------------PRPP-----------------------------M----A----
-LRSQVPSRHVLCLP-PRNVTLL---QERANKLVK------YLMIKD-YKKIPI--KR--
------------------------------------------------------------
----SDM---MKDVIREYDEHFPEIIERATYTLEKKFGIHLKEIDKEEHLYI-LVCTRDS
SAR-LL-GKTKDT-PRLS---LLL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPFLGDLRKLITEDFVKQK-------
---------YLEYKKVPNSSP---P--EYEFLWGLRARHETSKMRVLRFIAQNQNR---D
------PREWKAHFLEAVDDAFKTMDVDMA--EEHAR----AQMRAQMNIGDEAL-----
------IGR--WSWDDIQVELLT-WDEDGDFGDAWA-RIPF----AFWARYHQYILNSNR
ANRRA------TWRAGVSSGTNGGASTSILDGPSTS-ST---IRTRNAARTS--------
----ANFFSWIQQR----------------------------------------------
------------------------------------------------------------
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--------------------------------------------------------MAE-
----------------------------------------------------------GS
FS-----V-Q-------SENYSVEDMDEGSDEVG--EEEMVEGNDYE----EFGAFGGYG
TLTSFDIHI--LRVLGTGKLTQVCRR----------------VACLPQPLSLALQNEPWE
LENP-VLAQTLV-------EALQ--LDPETLANETAARAA-------------NVARAAA
---S----------NRA-ARAA--------------------AAAARTAFSQV---VASH
R-------------------------------------------------VAT-------
------PQVSGEDTQPTTYAA--EAQ--------------------GPTPEPPLASPQTS
------QMLVTSKMAAPEAPAT-SAQSQTGS---------------PAQ-----------
-------------EAA----------------TEGPSSACAFSQAPCAREVD-ANRPSTA
FLGQ----------------------------NDVFD-------FTQPAGV---------
----SGMAFPRPKRPAPAQEA--ATEGPSA---------AS-GVPQTGPGREVAATRPKT
T-----------------------------K-----------------------------
------------------------------------------------------------
--------------------------------------------------------SGKA
LAKTRWVEPQNVVAAA--------AAKA-KMATS---------IPEPEGAAA--ATAQHS
AE-----------------------P---------------------------------W
ARMGGKRTKKSKHLDDEY--------ESSE-EERETPAVPPTWRASQPSLT---------
---------V----R---------------------------------------------
----------------------------------------AQLA----------------
-----------------PRPP-----------------------------M----G----
-PRSQIPSRHVLCLP-PRNVTLL---QERANKLVK------YLMIKD-YKKIPI--KR--
------------------------------------------------------------
----ADM---LKDVIREYDEHFPEIIERATYTLEKKFGIHLKEIDKEEHLYI-LVCTRDS
SAR-LL-GKTKDT-PRLS---LLL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPFLGDLRKLITDDFVKQK-------
---------YLEYKKIPNSNP---P--EYEFLWGLRARHETSKMRVLRFIAQNQNR---D
------PREWKAHFLEAVDDAFKTMDVDMA--EEHAR----AQMRAQMNIGDEAL-----
------IGR--WSWDDIQVELLT-WDEDGDFGDAWA-RIPF----AFWARYHQYILNSNR
ANRRA------TWRAGVSSGTNGGASTSVLDGPSTS-ST---IRTRNAARAG--------
----ASFFSWIQHR----------------------------------------------
------------------------------------------------------------
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--------------I---------------------------------------------
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----------------PGN--LEEV---S---------------------AAE-------
----------M--------------------------------------PSTS-------
QGPQSAYS---CSTAQA-A--APWSLSDQ----------------G-SSR-QGEEGP---
------------G------TSQLQP------------DAESMLRDEIFDKVAELV-----
-------TFLLVKYRMKEPFT-RAEVL--EAVIQDHQ-----DHFSVIFGEASEC-----
----LQLVFGID---------VKK-VDPAG---------QCYV-----------------
-------L----------------------------------VSTLGL-TYD----ETLS
---D-SHSMPKTGLL-------VTVLGVIFLEGNR------VPEK---EIWKLLSVM---
-----GVY-PGR----EHFIYGEPRKLLTRDWVQE------QYLEYRQI-PGSEPACYEF
----LWGPRAHAETS--KMKVLEGLAKVYGTVPS----A-FSTWYEE---ALRDEEERA-
------------------------------------------------------------
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---------------------------------------YSP-P----------------
-----------------QNS-LELGT-E----------------DSSA----QRE-THG-
-------------QEGAQVPGGEE------------------------------------
-----------------------------------------------------------E
E-AM-----------------------RALSAS---------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------A---ANSS
SSPQRTCT---FLSAIS-A--AQATMSAE----------------G-PSS-QIEEE----
-------------------ASRALP------------DTEPWRRNRLGQKVIHLV-----
-------KFLLLKNRRKEPTT-KAEIL--SLVIRNYN-----SHFPVIFRRALEV-----
----MQLIFGID---------MKP-AGPTG---------HSYV-----------------
-------L----------------------------------VPTLGL-TYD----GMPP
---GGVPSAPKTSLL-------ILVLGVIFLEGNC------AREE---KIWKVLGMI---
-----GVY-AEQ----EHFIYGEPRRLLTQDWVQE------RYLVYRQG-SSSLPGCSEL
----LWGPRAHAETS--KMKVLGFLAKASGTDPS----S-FPSHYAE---ALREEEERG-
------------------------------------------------------------
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--------------------------------------MPRGQK---SKLRAREKR-RQA
-RG-----GLEDL-----------------------------------------------
-ID-------------ALDILEEE------------------------------------
-----------------------------------------------------------E
-ESP-------------------------PSASA-----C---------------LKDVF
QS-S-L------------------------DGASN-------N-------PHGLRE---A
Q--STSTSAT-A------------------------------------------------
------------------------------------------------------------
-----------------AS----HTRHPEGV---------------ND-Q-ME-ERP---
-----------------------------IC-TQDLEATDSFPRGPVDEKVIILV-----
-------HYLLYKYQMKEPIT-KADML--RNVTQMSK-----SQFPVILSRASEH-----
----LELIFGLD---------LKE-VEPNK---------HIYV-----------------
-------L----------------------------------VNKLDL-GCD----AKLS
----DETGVPKTGLL-------MTVLGIIFTNGNC------VAEE---EVWKVFNTM---
-----GLY-DGI----EHFMFGEPRKLLTKDLVKE------NYLEYQQV-PNSDPPRYQF
----LWGPRAHAETS--KMKVLEFLAKVNDTAPS----E-FSNWYTE---ALQDEEERAR
AR-VAAKARVS-AT----------------------------------------------
----------------------------------------------------------AG
--------------------ARS--K-----------------------VKSS-KSSQLQ
------------------------------------------------------------
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--------------------------------------MPRGQK---STLHAREKC-QQT
-WG-----QIQGR-----------------------------------------------
-QG-------------AQITATQK------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-KKS-A------------------------GRSGS-------V-------LKKPQR---A
L--STT-TSV-D------------------------------------------------
------------------------------------------------------------
-----------------VY----HKKSYKGA---------------NS-K-TE-KKQ---
-----------------------------SF-SQGLSSTVQSRTDPLTIKTKMLV-----
-------QFLMEMYKMKKPIM-KADML--KIVQKRHE-----NHFPEILKKASFN-----
----MEVVFGVD---------LKK-VDSTK---------DSYV-----------------
-------L----------------------------------VSKMDL-PNN----GAVT
----RGRGFPKTGLL-------LNLLGMIFMKGNC------ATEE---KIWEFLNKM---
-----RIY-DGK----KHFIFGEPRKLITQDLVKL------KYLEYRQV-PNSNPARYEF
----LWGPRAHAETS--KMKVLEFWAKVNQTVPS----A-FHFWYEE---ALRDEKERVE
AA-ATFNDGSS-AM----------------------------------------------
----------------------------------------------------------GR
--------------------KCSKVK-----------------------ASS---SSHA-
------------------------------------------------------------
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--------------------------------------MSSEQ-----------------
-----------------RSQ-HCKPE-E----------------GLEA----QGEGALG-
-------------LVCAQASAT-E------------------------------------
-----------------------------------------------------------E
H-E---------------------------------------------------------
------------------------------------------------------------
----AASSSTLV----EGT--LEE------------------------------------
---------VP-------------------------------------------------
---AGSSS---SLTISD-N--TLWSQSSE----------------GISS--REEEG----
-------------------TSPDPA------------HLESLFREALDEKVAELV-----
-------HFLLRKYQIKEPVT-KAEML--ESVIKNYK-----NHFPEIFSKASEC-----
----MQVIFGID---------VKE-VDPAG---------HCYV-----------------
-------L----------------------------------VTCLGL-FYD----GLLG
---DD-QSTPKTGLL-------IIVLGMIVMEGSC------APEE---AIWEALSVM---
-----GLY-DGR----EHSVYWELRKLLTQDWVQE------NYLEYRQV-PGSDPVRYEF
----LWGPRALAETS--YVKVLEHVARVNARVCI----S-YPS-----------------
------------------------------------------------------------
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--------------------------------------MPRGQK---SKLRAREKR-QRT
-RG-----QTQDL-----------------------------------------------
-KV-------------GQPTAAEK------------------------------------
-----------------------------------------------------------E
-ESP-------------------------SSSSS-----V---------------LRDTA
SSSL-A-------------------------FGI----------------PQEPQR---E
P--PTTSAAAA-------------------------------------------------
------------------------------------------------------------
-----------------MS----CTGSDKGD---------------ES-Q-DE-ENA---
-----------------------------SS-SQASTSTERSLKDSLTRKTKMLV-----
-------QFLLYKYKMKEPTT-KAEML--KIISKKYK-----EHFPEIFRKVSQR-----
----TELVFGLA---------LKE-VNPTT---------HSYI-----------------
-------L----------------------------------VSMLGP--ND---GNQ-S
----SAWTLPRNGLL-------MPLLSVIFLNGNC------AREE---EIWEFLNML---
-----GIY-DGK----RHLIFGEPRKLITQDLVQE------KYLEYQQV-PNSDPPRYQF
----LWGPRAHAETS--KMKVLEFLAKVNDTTPN----N-FPLLYEE---ALRDEEERAG
AR-PRVAARRG-TTAM--------------------------------------------
--------------------------T--------------------------------S
--------------------AYS--R-----------------------ATSS-SSSQPM
------------------------------------------------------------
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--------------------------------------------------MLQTPE---S
R--------------------------------------------------GLPVP----
-------QAE----------------------------GEKNGGHDGETRART-----A-
-SQE-------------------RPKEELVS---------------GREE-G--------
----------------AAEPALTRKGA--RA-LAAKALARRRACRRLNRTVAELV-----
-------QFLLVKDKKKSPIT-RSEMV--KYVIGDLK-----ALFPDIIARAAEH-----
----LRYVFGFE---------LKQ-FDRKH---------HTYI-----------------
-------L----------------------------------INKLKPLEEE----E---
EEEDLGGDGPRLGLL-------MMILGLIYMRGNR------AREA---QVWEMLHRL---
-----GMQ-PSK----YHFLFGYPKRLIMEDFVQQ------RYLSYRRV-PHTSPPEYEF
----SWGPRSNLEIS--KMKVLGFVAKLHKKEPQ----H-WPVQYRE---ALADEADRAR
AKAR-AEASMRARA--------SARA------G---------------------------
------------------------------------------------------------
-IH----L------W---------------------------------------------
------------------------------------------------------------
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---------------------------------------MAQKMDCGAGLLGFQSPDA--
--CRAVCHPLPQPPASTLPLSAFPT-LCDPPYSQLRDPPPVLSCYCTPLRASLAPAEASV
EDSA-LLMQTLM-------EAIQ--IS-EAPPTNQA--TA--------------------
------------------------------------------A-----ASPQSSQPPTA-
N------------------------------------------------EMAD-------
------IQVSAAAARPKS------------------------------------------
-----------------------------AF---------------KVQ-----------
-------------NAT----------------TKGPNGVYDFSQAHNAKDVP-NTQPKAA
L-------------------KSQNATP--KGPNAAYD-------FSQAATT---------
----GELAANKSEMAFKAQNAT-TKVGPNA---------T-YNFSQSLNANDLANSRPKT
------------------------------------------------------------
----------------------------------------------PFKAWNDTTKSPTA
-------------------------------DTQT-----------QNV-----------
----NQA---KMATSQ--------ADIETD--PG---------ISESDGATAQTSADGSQ
AQNLE--------------------S---------------------------------R
TIIRGKRTRKINNLNV---------EENSSGDQRRAPLAAGTWRSAPVPVTT-QNPPGAP
PNVLWQTPLA----WQNPS----GWQNQTARQTP----P-ARQSPPARQTPPAWQNPVAW
QNPVIWPNPVIWQNPVIWPNPI-VWPGPVVWPNPLAWQNPPGWQTPPGWQTPPGWQGPPD
WQG---PPDWPLPPDW-PLPP-DWPLP-TDWPLPPDWIPADWPIPPDWQNLRPSPNLRP-
-SPNSRASQNPGAAQ-PRDVALL---QERANKLVK------YLMLKD-YTKVPI--KR--
------------------------------------------------------------
----SEM---LRDIIREYTDVYPEIIERACFVLEKKFGIQLKEIDKEEHLYI-LISTPE-
SLAGIL-GTTKDT-PKLG---LLL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPLLGDLRKLLTYEFVKQK-------
---------YLDYRRVPNSNP---P--EYEFLWGLRSYHETSKMKVLRFIAEVQKR---D
------PRDWTAQFMEAADEALDALDAAAA--EAEAR----AEARTRMGIGDEAV-----
------SGP--WSWDDIEFELLT-WDEEGDFGDPWS-RIPF----TFWARYHQNARSRFP
QTFAG---------------------P--IIGPGGTAGA------NFAANFGAIGF----
--------FWVE------------------------------------------------
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--------------------------------------MPRGQK---SKLRARERR-HQA
-QV-----EPQNP-----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------G-LQRATNTESIQRGHIDEKVVIMV-----
-------YYLLYKYNLKEPIR-KAEML--REVIQMYR-----SHYLEILRRAAEH-----
----MEMIFGLD---------LKE-VDPYR---------HIYI-----------------
-------L----------------------------------VNKMEV-SCD----ARLI
----NRIEIPKTGLL-------MAILGVIFMQGNC------ASEE---RVWQTLNVM---
-----GLF-NGR----KHFIFGEPKKLITKDLVQQ------KYLEYRQV-ANSDPPCYEF
----LWGLRAHAETT--KMKVLEFMAKIHNMVPT----A-FPSLYEE---ALRDEEERAQ
AR-ASARARTA-AL----------------------------------------------
----------------------------------------------------------AK
--------------------ARS--S-----------------------AIAS-SSSHSK
RV----------------------------------------------------------
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--------KGRKKREDS--RDLGVQISGDLSPGRFQR-----VTEVN-------------
---------------------TG----SPSFLQTQHSESQD-LTRVQVIR--GQRDQEVK
SCGTPQ---SSTEREDRLWVPIAQLLPTLPPATLIRVIMPRA-P----------------
-----------------KRQ-RCMPE-E----------------DLQS----QSE-TQG-
-------------LEGAQAPPAVE------------------------------------
-----------------------------------------------------------E
D-AS-----------------------SSTST----------------------------
------------------------------------------------------------
----------SL----PST--PEE--VSA---------------------DEG-------
----------T--------------------------------------PNPP---QSA-
---QVACS---SPSVIA-S--LPLDQSDE----------------G-FGS-QKEESP---
------------S------TLQALP------------DNESLPRSEIDEKVTDLV-----
-------EFLLFKYQTKEPIT-KAEIL--ESVIKNYE-----EHFPVMFSEASEC-----
----MLLVFGID---------VKE-LDPTG---------DSFV-----------------
-------L----------------------------------VTSLGL-TYD----GMLS
---DV-QSMPKTGIL-------ILILSIIFIEGYC------TPEE---VIWEALNMM---
-----GLY-DGM----EHFIYGEPRKLLTQDWVQE------NYLEYRQV-PGSDPARYEF
----LWGPRAHAEIR--KMSLLKFLAKVNGSDPR----S-FPLWYEE---ALKDEEERA-
------------------------------------------------------------
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--------------------------------------MPHS-Q----------------
-----------------KSR-HCELE-Q----------------GLQA----PKE-AQG-
-------------LVGVQVAEAEK------------------------------------
-----------------------------------------------------------V
N-TT-----------------------A-S------------------------------
------------------------------------------------------------
-----SSSSTLI----QGT--LEKV---S---------------------ASG-------
----------T--------------------------------------PGTP-------
QSSQKVCS---SCTTIK-A--TPWNQSDE----------------S-SRS-LEKKDP---
------------G------ASQALP------------EPESLLGSMLEKKVDELV-----
-------KFLSVKYTTKQPIT-EAEMV--KGVIKEHK-----DHFPPIFMQAHEC-----
----MQIVFGID---------MKE-VDPIS---------HSCV-----------------
-------L----------------------------------LKSLDL-TYD----RRLS
---DD-QGMPKSGLL-------ILILGVILMEANC------ASEE---KIWEVLNII---
-----RVY-AGW----EDFIYGEPRKLITRDLVQE------KYLECCQV-SNSDPPRYKF
----PWGPRAHAETT--KMKVLEFFSRVSGNDAS----S-FPLLYEE---ALRDEKEKAQ
AIIATMGGTTL-------------------------------------------------
------------------------------------------------------------
-----------------------MA--------S----------------AHS----RA-
------------------------------------------------------------
---------KSS---------------------SFSC-----------------------
------------------PK----------------------------------------
------------------------------------------------------------
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--------------------------------------MSLEQ-----------------
-----------------RSL-HYKPE-E----------------ALEA----QQE-ALG-
-------------LVCVQA-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---AASSSSPLV----LGT--LEE------------------------------------
---------VP--------------------------------------TAGS---TDPP
QTPQGAST---FPTTIN-F--PRWRQPNE----------------SSSS--HEVKGP---
------------S------TSRVL---------------ESLFRAVLTKKVADLV-----
-------RFLLLKYRAREPVT-KAEML--ESVIKNYK-----HCFPVIFGKASES-----
----LQLVFGID---------VKE-ADSTG---------HSYV-----------------
-------L----------------------------------VTCLGL-SYD----GLLG
---DN-QIMPKTGFL-------IIILVMIAMEGGH------APEE---EIWEELNVM---
-----EVY-DGR----EHSAYGEPRKLLTQDLVQE------KYLEYRQV-PYSDPARYEF
----LWGPRALAETS--YVKVLEYVIKVSARVRF----F-FPSLREA---ALRQEGAAL-
------------------------------------------------------------
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------------------------------MPR---------------------------
----------------------GQKSK-------------------------------SR
--------------------SRAKRQ-QARSELQG---LPAVHH--TAEEAAS-LSV---
----------------------DRRDGSN-FP---DGCTPQGMK-T-------------P
---------GSLS---A----------------AVSGIGSVLG---------VSNAVVVA
GKQSSDATQAATSIQ-HTLKDPI---MRKASVLIE------FLLDKF-KMKEAV--TR--
------------------------------------------------------------
----SEM---LAIVNKKFKEQFPEILRRTSARLELVFGLELKEIDPSTHSYL-LVGKLGL
STEGSL-SSNWGL-PRTG---LLM----------SILGV----------IF--------M
-KGNR----A-T--EQEVWQFLNGVGVY--AGKKHLIFEEPGEFI-KDLVQEN-------
---------YLEYHLIPGSDP---P--NYEFLWGPRAYAETTKMKVLEVLAKVNGT---V
------PSAFPNLYQLALRDQARGARRRPQ-GR-RV-------------HSKPLSQ----
------------------------------------------------------------
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--------------------------------------MPWRHK---NKLHAHGKC-HLV
-RS-----DTQEA-----------------------------------------------
-QA-------------SAAAAPKE------------------------------------
-----------------------------------------------------------E
-CP--------------------------SSRSS-----A---------------PQGSP
LSSP-A-------------------------AGN----------------RQELQG---A
M--APSSADA-G------------------------------------------------
------------------------------------------------------------
-----------------PS----CAGSDEGA---------------QG-P-EE-ESA---
-----------------------------GA-SQAAPATQSTRKDPLARKARILV-----
-------EFLLEKYTKKEPIT-QNALM--KIVSRKYR-----KHFPEILSTAREC-----
----VELVFGLE---------MKE-VDRSR---------NIYT-----------------
-------L----------------------------------ISKLNL-GGN---DCP-S
----GEVGLPKSGLL-------MVLLGVIFMNGNR------ATEE---EIWEFLSML---
-----GIY-AGR----RHWIFGEPRRLITKDLVQK------EYLNYRQV-PNSDPPRYEF
----LWGPRACADTS--KMKVLEVLAKFHGRLPS----S-FPDLYEE---ALRDQAERTG
LR-GAARAPTM-AK----------------------------------------------
----------------------------------------------------------AS
--------------------APS--K-----------------------AKSG-SSSHI-
------------------------------------------------------------
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--------------------------------------------------------MAE-
----------------------------------------------------------GS
YR-----V-E-------SESYNVEDMDEGGDEVG--EEDMVEGNDYE----EFGAFGSYG
TLTSFDIHL--LRAFGSLG-----------------------------PGLHILSNEPWE
LENP-VLAQTLV-------EALQ--LDPETANETXXXXXX-------------XXXXXXX
---X----------XXX-XXXX--------------------XXXXXXXXXXX---XXXX
X------------------------------------------------XXXX-------
------XXXXXXXXXXXXXXX---XX--------------------XXXXXXXXXXXXXX
------XXXXXXXXXXXX--XX-XXXXXXXX---------------XXX-----------
-------------XXX----------------XXXXXXXXXXXXXXXXXXXX-XXXXXXX
XXXX----------------------------XXXXX-------XXXXXXX---------
----XXXXXXXXXXXXXXXXX--XXXXXXX---------XXXXXXXXXXXXXXXXXXXXX
X-----------------------------K-----------------------------
------------------------------------------------------------
--------------------------------------------------------SGKA
LAKTRWVEPQNVMTAA--------AAKA--KVTS---------IPEPESAIA---TTQPG
AD-----------------------P---------------------------------W
ARLGGKRTKKSKHLDDEY--------ESSE-EERETPTVPPTWRASQPSLT---------
---------V----R---------------------------------------------
----------------------------------------AQLA----------------
-----------------PGPP-----------------------------T----T----
-QRSQIPSRHVLCLP-PRNVTLL---QERANKLVK------YLMIKD-YKKIPI--KR--
------------------------------------------------------------
----SDM---LKDVIREYDEHFPEIIERATYTLEKKFGIHLKEIDKEEHLYI-LVCTRDS
SAR-LL-GKTKDT-PRLS---LLL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPFLGDLRKLITDDFVKQK-------
---------YLEYKKIPNSSP---P--EYEFLWGLRARHETSKMRVLRFIAQNQNR---D
------PREWKAHFLEAVDDAFKTMDVDMA--EEHTR----AQMRAQMNIGDEAL-----
------VGR--WSWDDIQVELLT-WDEDGDFGDAWA-RIPF----AFWARYHQYILNSNR
ANRRA------TWRAGVSSGTNGGASTSVLDGPSTS-ST---IRTRNAARAG--------
----ASFFSWIQHR----------------------------------------------
------------------------------------------------------------
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--------------------------------------MPRGQK---SKHRAREKR-RQA
-RA-----EIQGL-----------------------------------------------
-HD--------------QATTSRG------------------------------------
-----------------------------------------------------------E
-ETT-------------------------SFSPP-----D---------------SESAP
SSSS-A-------------------------AGT----------------ATGPPG---A
Q--GTTSAAAGAIRKRSGGGGA--------------------------------------
------------------------------------------------------------
--------ARSRSGVGGIA----RLKSGGGA---------------EG-Q-VQGGE----
-----------------------------NS-SQASAAAESSHTDLLTMESENLV-----
-------KYMLLKYKMRELIK-RSEMV--KVIHRRYK-----AQFPEILSRASEH-----
----MEMVFGLV---------LKE-VRPNS---------HCYT-----------------
-------L----------------------------------VSNLDL-SDS----ESMR
----GDWGLPKNGLL-------MPLLGVIYLNGHR------ASEE---EVWKFLNIL---
-----GIY-DGR----MHFIFGDTRKLITEDLVQE------EYLEYNQV-PGSDPPHYEF
----LWGPKALTENS--KTKVLQFLTKVNDLVPD----A-LLPHYEE---ALREEAERTG
ARAAT-GTGPSASAS-----PG---PSASARPG---------------------------
-----------------------TSA----------------------------------
-A--------------------ARAGTSASARADM-----SA---------LASGGPSAS
ARD-----------------G-TSAAAR--------------------------------
-------------------AG-TSASTSAHSRATSSHS----------------------
------------------SGP---------------------------------------
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--------------------------------------MPRGQK---SKRRAREKR-RQA
-RS-----KTQGP-----------------------------------------------
-GS-------------AQATAAEV------------------------------------
-----------------------------------------------------------E
-ES---------------------------PSSP-----V---------------PGGTP
SSSA-A-------------------------AGT-------------------SQG---V
P--AP-SSPAAG------------------------------------------------
------------------------------------------------------------
-----------------VS----RPRSRVGA---------------KS-R-VK-KSE---
-----------------------------NF-SQASTSTESARNDLLTRKASMLM-----
-------EFLLEKYKMKEPIR-KVDML--KLVHKRYK-----EDFPEILRRASER-----
----IELVFGLD---------LKE-VKPNG---------QSYT-----------------
-------L----------------------------------VSKLDV-CDD---GSM-S
----DDWEYPKSGLL-------MPLLGVIFLNGNC------ASEE---EIWGFLNIL---
-----GIY-DGR----EHLIFGEPRKLITKDLVQQ------KYLEYRQI-PDSDPPRFEF
----LWGPRAHAETS--KMKVLEFLAKINGTTPS----A-FPFHYEE---ALREEEERAP
AR-AAA------------------------------------------------------
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---------------------------------------MAQKPDGGAGLRGFQA-----
--------------------------------------------------------EASV
EDSA-LLVQTLM-------EAIQ--IS-EAPPTNQA--TA--------------------
------------------------------------------AASGQNASPQSSQPPTA-
N------------------------------------------------EVAD-------
------TELSTAAARPKT------------------------------------------
-----------------------------GF---------------KAQ-----------
-------------NTT----------------AKGPN---DFSQARNAKEMP-KNQSKVG
F-------------------KSQNGTS--KGPNAASD-------FPQAAST---------
----GKS-AKKSEMAFKAQNTT-TKAGPSA---------A-YNFSQPPSANEMTNNQPKT
------------------------------------------------------------
----------------------------------------------ATKAWNDTTKVPAA
-------------------------------DAQI-----------QNV-----------
----NQA---KMADIG--------T------SPG---------ISETDGAAAQTSADGSQ
AQNVE--------------------S---------------------------------R
TIIRGKRTRKINNLNV---------EESSSGDQRRASLASGNWRSAPVPVTT-QNPPGAP
PNVLWQTPLA----WQNPS----GWQNQTARQTP----P-ARQSPPARQTPSAWQNPVAW
QNPVIWPNPVIWQNPVIWPNPI-VWPGPIVWPNPMAWQNTPGWQSPPSWQAPPSWQGPQD
WQG---PPDWQLPPDW-SLPP-DWSFP-TDWPFPPDWIPADWPIPPDWQNLRPSPNLRS-
-SSNSRASQNQGAPQ-PRDVALL---QERANKLVK------YLMLKD-YTKVPI--KR--
------------------------------------------------------------
----SEM---LRDIIREYTDVYPEIIERACFVLEKKFGIQLKEIDKDEHLYI-LISTPE-
SLAGIL-GTTKDT-PKLG---LLL----------VILGI----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPLLGDLRKLLTYEFVKQK-------
---------YLDYRRVPNSNP---P--EYEFLWGLRSYHETSKMKVLRFIAEVQKR---D
------PRDWTAQFMEAADEALDALDAAAA--EAEAR----AEARTRMGIGDEAV-----
------SGP--WSWDDIEFELLT-WDEEGDFGDPWS-RIPF----TFWARYHQNARSRFP
QAFTG---------------------P--IIGPSGTATA------NFAANFGAIGF----
--------FWVE------------------------------------------------
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--------------------------------------MPCGQK---SKHCAREKC-PQA
-RA-----ETQGL-----------------------------------------------
-HD--------------QATTSGG------------------------------------
-----------------------------------------------------------E
-ETT-------------------------SSSPP-----D---------------SESAL
SSLS-A-------------------------AGT----------------SKGPPG---A
Q--GTTSAAAGAIRKRCGGGGA--------------------------------------
------------------------------------------------------------
------------------A----CSRSGVGA---------------EG-Q-VQEGE----
-----------------------------NS-SQASAAAESSHTDLLTRKAELLV-----
-------QYMLYKYKMRERIK-RSEML--QEINRRYK-----ERFPEILSRASER-----
----MELVFGLV---------LKE-VRPNS---------HCYT-----------------
-------L----------------------------------VSNLDL-SDT----ECMR
----GDLGLPKNGLL-------MPLLGVIYLNGNH------APEE---KIWKFLNLL---
-----GIY-DGR----SHFIFGEPRKLITEDLVRE------EYLEYRQV-PGSDPPRYEF
----LWGPKALTETS--KTKVLQFLAKVKDSVHP----A-LQPQYEE---AWREEVESTG
ARGAA-RA-------------G---TSASTRPG---------------------------
-----------------------AAA----------------------------------
-S--------------------AAAGRSASATAHP-----RAA-------SSHSSCA---
------------------------------------------------------------
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--------------------------------------MSLEQ-----------------
-----------------RSP-HCKPD-E----------------DLEA----QGE-DLG-
-------------LMGAQEPTGEE------------------------------------
-----------------------------------------------------------E
E-T---------------------------------------------------------
------------------------------------------------------------
---TSSSDSK-----------EEE------------------------------------
---------VS--------------------------------------AAGS---SSPP
QSPQGGAS---SSISVY-Y--TLWSQFDE----------------GSSS--QEEEEP---
------------S------SSVDPA------------QLEFMFQEALKLKVAELV-----
-------HFLLHKYRVKEPVT-KAEML--ESVIKNYK-----RYFPVIFGKASEF-----
----MQVIFGTD---------VKE-VDPAG---------HSYI-----------------
-------L----------------------------------VTALGL-SCD----SMLG
---DG-HSMPKAALL-------IIVLGVILTKDNC------APEE---VIWEALSVM---
-----GVY-VGK----EHMFYGEPRKLLTQDWVQE------NYLEYRQV-PGSDPAHYEF
----LWGSKAHAETS--YEKVINYLVMLNAREPI----C-YPSLYEE---VLGEEQEGV-
------------------------------------------------------------
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-----------------------------------------------------MSEQSKD
VCD---------------------------------------------------------
------------------------------------------------------------
--------PNF----------------------------T---------------AEP-S
NSEV--------------------------YGS-----------------PGVPGG---P
S--PPASQAAT----------LAGPESPPLGP------------T---------------
----DASLAL--------------------------------------------------
------PPS--------------QAPSEEGD---------PKAL-QQA-A-EE--GR---
----------------------AHQAP----SAAQPS-PTPPAPAQLVQKAHELM-----
-------WYVLVKDQKRMIIW-FPDMV--KDVIGSYK-----KWCRSILRRTSLI-----
----LARVFGLH---------LRL-TSLHT---------MEFS-----------------
-------L----------------------------------VKALEPEELD-----RVA
----LSNRMPMTGLL-------LMILSLIYVKGRG------ARES---AVWNVLRIL---
-----GLR-PWK----KHSTFGDVRKLITEEFVQQ------NYLKYQRV-PHVEPPEYEF
----FWGSRASREIT--KMQIMEFLARVFKKDPQ----A-WPSRYRE---ALEEARALRE
ADPTA----------------------------------HCPRSSVSED-----------
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-----RSPPKSPQRAASVS----CADSDKGA---------------TG-Q-NEEGP----
-----------------------------SS-S---QASESSCEDPLNKKVVLLV-----
-------QFLLRKYHDKEPIT-RAEML--KSVVKKYR-----CHFPEILKRAAEH-----
----MELALGVD---------LKE-VDPIR---------HCYA-----------------
-------F----------------------------------VSKLDF-TAD----DMVI
----DEENVPKTGLL-------MIVLGVIFTKGNC------ATEE---EVWEVLNMM---
-----GVY-ADR----QHFLYGEPKKVITQELVQM------KYLEYRQV-PNSDPPRYEF
----LWGPRAHAETS--KMKVLEFLAKVNDTTPS----A-FPSWYEE---ALKDEEERAR
ARIE-ARARSS-AKASARSKAMPS------------------------------------
------------------------------------------------------------
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--------------------------------------MSHRQ-----------------
-----------------QHE-QG-LK-A----------------LKE-------------
------------------------------------------------------------
---------------------------------------------------KEGP-----
--V---------------------------------------------------------
---------------------------------------------------------AKH
VGNPEE------------------RP----------------------------------
---------AA--------------------------------------VV---------
-SQKAS------------------SSAAP----------------IQPTX-XXX--X---
------------X------XXXAYL------------YSKFLLNSQIRKKTTDLV-----
-------KFLSFKYTRNEPVT-EADIL--KNVVQEYK-----DYYSLIFKHACEC-----
----MEVVFGIE---------IKE-VDAFN---------HSYE-----------------
-------L----------------------------------LKILDL-TYD----GRLS
---ED-EGIPRTGLL-------ALILGVIFMEGNR------APEK---KIWEVLNMV---
-----GVY-PDQ----HDFICGNPRKFITEDLVLE------KYLECKLV-SRSYPPTYEF
----LWGPRAHAESS--KMKVLQFFSKVAGSNPT----S-FTALYKE---ALKDEEERAR
AILASTSIASP-------------------------------------------------
------------------------------------------------------------
-----------------------SA------PDN----------------SGS--G--E-
------------------------------------------------------------
---------KPS---------------------SFSH-----------------------
------------------PK----------------------------------------
------------------------------------------------------------
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---------------------------------------MDRRNDYGYGLPPFQ--G---
--------PLPPP--GSLGLP----------------------------FPPDIQTETTE
EDSF-LLMHTLL-------AATK--DPLAMDPPVVNRPKK-------------SKTKKAP
IKAI----------TKA-APA--APPVLTASEIATNKPKITLQALNLPVITQISQASPT-
T------------------------------------------------EVAN-------
------TQASSVTSQPKKASKMKRFTAKSAQG-SQSPAGYEGVTTQLKSPLQVLNLPVIS
QNIHV---PIASESASSQAL-ITSIKPKKAF---------------KTK-----------
-------------KFV----------------NKAIASATEVSLAPNATHTA-ITQGQIT
-SETASIHTTAASIRTKKASKAKKTTA--KVINTDTE-------HIEARNV---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------TEAAT
RQIEA--------------------S---------------------------------V
VAIRPKKSKSKKAASRGQ---------N------------SLSEISEVPLATQMVTNQAL
AATLRVKRGS----RARKS----ATKSRATESQT----PVADQGSQAKMATAQ-TNVSAL
QTQ------------VA------------AAVQALADDYLAQL----SLEPTTRTRGKRN
RK-----------------------------------------------SKHLNGDERS-
GSNYRRIPWGWRPAP-PRDVAIL---QERANKLVK------YLLVKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LRDVIQEYDEYFPEIIERASYALEKMFRVNLKEIDKQSSLYI-LISTQES
SAG-IL-GTTKDT-PKLG---LLM----------VILSV----------IF--------M
-NGNK----A-S--EAVIWEVLRKLGLR--PGVRHSLFGEVRKLITDEFVKQK-------
---------YLEYKRVPNSRP---P--EYEFFWGLRSYHETSKMKVLKFACKVQKK---D
------PKDWAVQYREAVEMEVQAAAVAVA--EAEAR----AEARAQMGIGEEAV-----
------AGP--WNWDDMDIDCLT-REELGDDAQAWS-RFSF----EIEARAQENADASTN
VNFSRGASTRAGFSDGASISFNGAPSS--SGGFSG-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------GPGITFGGAPSTSASFSSTASISFGGTLSTSS----------------
--------------------SFS------------------S----------------AA
SISFGGAHSTSTSFSSEASISFGGMPCTSANFSGGVSSSFSGPLS--TSATFSGGANSGF
GG------------------IL-STTAGFSGVLSTSTSFDSAPTMSTVFSSALSTSTGFG
GTLSTSVCFGGSPSSSGSFGGTLSTSICFDGSPCTSTGFGG----TLSTSVSFGGSSSTS
ANFGGTVSTSICFDGSPSTG-AGFGGALNTSASFGGALNSS-------------------
-------------------------------------------------ADFGGAMSTCA
DFGGTLSTSVCFGGSPCTSVSFGGALNTNAGFGGAVSTSTDFGG----------------
------------------------------------------------------------
-----ILSTSVC------------------------------------------------
----------------------FGGSPSTSAG----------FGCAVSTGAGFSGAVSTS
AGFTGAPSTNSGFGGAFSTSAGFSGALSTTTDFGGTPSNNIGFGAAPSTSVSFGGAHSTS
LCFGGAPSTSLCFGSASNTNLCFGGPPSTSACFSGATSPGFGDGPSISTGFSFGNGLSTS
AGFGGGLSTSAGFGGGLGTSAGFSGG------------------------------LSTS
CGLDGGLGTSAGFGGGPGTSTGFGGGLGTSAGFSGGLGTSAGFGGGLVTSGAFGGGLGTN
ASFGSTLGTSAGFSGGLSTSDGFGSRPNASFDRGLSTIIGFGSGSNTSTGFTGEPSTSTG
FNSGPGSIVGFSGGPSTGVGFCSGPST-SGFSGGPSTGAGFG------------------
------------------------------------------------------------
-------GGPNTGAGFGGG-PSTSVGFGSGAASLGACGFSYG

------------------------------------------------------------
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------------------------------------------------------------
-----------------------------------------------------MSEQSKD
LSD---------------------------------------------------------
------------------------------------------------------------
--------PSF----------------------------A---------------AEA-P
SSEA--------------------------QSS-----------------PGVPGG---V
P--PS----AT----------LAEPQSPPLGP------------T---------------
----AAPQAA--------------------------------------------------
------QPP--------------QAPIEEVD---------PKAL-LEA-A-EE--GR---
----------------------AHQAP----SAAQPG-PAPPAPAQLVQKAHELM-----
-------WYVLVKDQKKMIIW-FPDMV--KDVIGSYK-----KWCRSILRRTSLI-----
----LARVFGLH---------LRL-TSLHT---------MEFA-----------------
-------L----------------------------------VKALEPEELD-----RVA
----LSNRMPMTGLL-------LMILSLIYVKGRG------ARES---AVWNVLRIL---
-----GLR-PWK----KHSTFGDVRKLITEEFVQQ------NYLKYQRV-PYVEPPEYEF
----FWGSRASREIT--KMQIMEFLARVFKKDPQ----A-WPSRYRE---ALEEARALRE
ANPAA----------------------------------HCPRNSVSED-----------
------------------------------------------------------------
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-----------------------------------------------------------R
SVSP-P-------------------------PGH----------------MLQKPR---S
R--------------------------------------------------SRPGA----
-------QPE----------------------------S---------------------
--------GTSWE----------VPSRSGHP---------------DAKQ-D--------
------------------TTGTLSSSS--RL-VQATPAPELRTQKQLELKVAELV-----
-------QFLLIKDQRKIPIK-RTGIL--KHVIRDYK-----DIFPDLLKLAAER-----
----LHYVFGYK---------LVE-LEPKS---------NAYI-----------------
-------L----------------------------------INALEPVEED----SEVR
----GNQGAPTTGLL-------MIILGLIFMNGHS------IPET---EVWDFLRRL---
-----GVY-PTK----KHSVFGDPKKLITEDFVRQ------RYLESRRI-PHTDPVDCEL
----QWGPRANLETS--KMKVLKFVAKVHNQDPK----V-WPTQYCE---ALADEQSRVG
LKPS-GSAPTS-------------------------------------------------
------------------------------------------------------------
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--------------------------------------MPCFQ-----------------
-----------------NGK-FFRHE-G----------------GLDQ----GEE-PDV-
-------------HEEIFESDKE-------------------------------------
------------------------------------------------------------
-EDKE-F-----------------------------FTTYS-------------------
SFTSSC---------------------------------------S----------PSSS
S-------PSLI----MST--TDE------------------------------------
---------FF--------------------------------------HVET---PSPA
QGPPECSPPL-STSSPY-A--FPWSQSDD----------------SCSTL-EWET-P---
------------T------TCQDPA------------DAESLLRGGMDAKMEELA-----
-------QLLLLRYRMEEPVT-KTEML--SCVIADYE-----DYYPVIFSKVSQC-----
----LLMVFGID---------VKD-ADSIS---------HCYV-----------------
-------L----------------------------------ETALGL-TYN----GM--
QD-HD-RSMPKTSFL-------IMVLGLIFSNGNR------VSEE---ELWEALSAL---
-----EVY-DGR----EHYIYGEPRRLLTEEWVRE------RYIEYRQV-PCSDPARYEF
----LWGPRTHAETT--KMRVLDFLARFSGGDIT----H-FPLCYEE---ALRDEEEKAQ
ARIDTSRGTSP-------------------------------------------------
------------------------------------------------------------
-----------------------MA------KTS----------------PSA--T--D-
------------------------------------------------------------
---------I--------------------------------------------------
-------------------------------FYRQ-------------------------
------------------------------------------------------------
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--------------------------------------MPRGQK---SKLRAREKR-RET
-HG-----PPQGL-----------------------------------------------
-TG-------------PQVTAEKQ------------------------------------
-----------------------------------------------------------E
-ESR-----------------------SSSSSSA-----V---------------CRSAR
RRSS----------------------------DSS-------V-------PQESQG---A
S--PTGSPDTGASCSKSDVAA----KGQDEKS------------PSTSRDASVSQEFQ-G
ASPTGSPDAGVSC---------SKS--------DMAAKGQDEKSPSTSPDASV-----PQ
ESQGASPTG---SPDADVS----GSKSDVAA---------------KGQ---EGESI---
-----------------------------SP-SERTVFFTTADRDPLNRKASKMV-----
-------QFLQEKFEKKESIL-KADML--RRVRRQYK-----PCFPEILKRTSER-----
----LAVVFGVE---------LKE-MDSSG---------ESYT-----------------
-------L----------------------------------VSKLGL-SSE----GSLS
----GDNALPKSGLL-------MSLLGLIFMKGNR------ATEE---EVWEFLGVL---
-----GIY-DGI----LHSIYGDTRKIITEDLVQD------KYVVYRQV-RNSDPPRYEF
----LWGPRAHAETT--KMKVLRVLAEINNTSPG----L-YPHLYED---ALIDEVERAL
RLRA--------------------------------------------------------
------------------------------------------------------------
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------------------------------MPR---------------------------
----------------------GRKSK-------------------------------LN
ARG--------------------RRL-RARNYAQA---SEGAEETVVATEESS-PKSCG-
--------------------------------------TSEMPE-K------------KS
---------DSSI---T-------------VDLFSIS--D-GS---------FIDL----
DDAEDLFMY--YHTI-N-HQDIL---TQKVLVLVQ------ILLKNY-RTKQLT--TM--
------------------------------------------------------------
----EDM---MQVIDEEEMNDFPEILRKAAERLADVFAVELREVESSRRLYD-LISKLKL
PNNGRV-RAGQGF-PKTG---FLM----------TVLGI----------IF--------M
-KGNC----A-S--EEDIWKTLRSLGIY--SGKKHRIYGEPRKLITQNFVKLK-------
---------YVEYRQVANSNP---P--RYEFLWGPKAYAETNKMTILKFVAKVNEV---S
------PSYFTGLYKETLKDDLGKNQGNRK-VSSAIHPKA-REFS----FVMCPGLAFSS
AEV---------------------------------------------------------
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--------------------------------------MPRGHK---SKLRAREKR-RLA
-RG-----QSQDL-----------------------------------------------
-GG-------------AQATVAEE------------------------------------
-----------------------------------------------------------E
-GAP-------------------------SSSSS-----V---------------VEGSP
QSLP-A------------------------AKPRG-------N-------PQGPRR---G
P--STTTTSA-G------------------------------------------------
------------------------------------------------------------
-----------------VS----RTQSDEGA---------------KC-Q-DE-ESP---
-----------------------------ST-SQGLFTTDRSGKNPLDQKAILLV-----
-------QFLLRKYNMKEPIT-KEDML--KCVIKKHR-----YYFHEILRRASEL-----
----MVLAFGID---------VKE-VDPTR---------HYYA-----------------
-------L----------------------------------VSKLQR-NSD----GRLN
----G-EIMPKTGLL-------MTILCVIFMKGNC------ATEE---EVWEVLNVM---
-----GIY-AGK----KHVIHGEPKKLITVDLVRE------RYLEYRQV-PDSDPPRYEF
----LWGPRAHAETS--KMKILEFLAKIHDTVPS----A-FPAWYEE---AVRDEEERAR
AR-FAAMFRTT-VV----------------------------------------------
----------------------------------------------------------AN
--------------------ARF--R-----------------------ANSS-SFSHP-
------------------------------------------------------------
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--------------------------------------MPRGQK---SKLRAREKR-RQA
-RQ-----ESSDR-----------------------------------------------
-VE-------------AQPTEPKE------------------------------------
-----------------------------------------------------------E
-EFP-------------------------SSPSP-----S---------------FEDVP
QSSA-A------------------------TGTSS-------S-------LQVPGK---I
C--STT-VAA-S------------------------------------------------
------------------------------------------------------------
-----------------VS----DAKFSEGA---------------TD-Q-GE-EKP---
-----------------------------KV-SQSQDTTKRCPKDPVDKKVALLV-----
-------NYLLIKYQMKEPVT-KRDML--RNVIHKYK-----NHFSEILRKASEH-----
----LELLFGLD---------VKE-TDPNK---------GTYV-----------------
-------L----------------------------------VNKMEL-GSD----EKLG
----DDREIPKTGLL-------MIVLGVILTKGNC------ATEE---QVWEVLNMM---
-----ELY-EEK----KDAIYGDVKQLITKDLVQE------KYLEYRQV-ANSDPPRYEF
----LWGPRAYTETT--KMKVLEFVAKIHDTVPA----A-FPSLYKE---ALRDEEERAQ
AR-ASARAHTA-AL----------------------------------------------
----------------------------------------------------------AS
--------------------ARS--W-----------------------ATAR-GFSCTK
------------------------------------------------------------
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--------------------------------------MPYI-E----------------
-----------------ESQ-QCKTD-Q----------------DLEA----QGK-AQG-
-------------LEDSQVPAVEK------------------------------------
-----------------------------------------------------------E
K-A---------------------------------------------------------
------------------------------------------------------------
---TACSSTPI-----SGT--SEKV---S---------------------AP--------
------------------------------------------------------------
-GTSGTCE---STTPVE-A--TPCSQSEE----------------G-SSS-QGKKKP---
------------G------ASQFLQ------------DPDSLLSNMLEKKVSDLV-----
-------KFLSVKYTKKESLT-KAEML--KSISKEHK-----DHFPWIFMKACEC-----
----MEVVFGID---------VKE-VDPIH---------HSYV-----------------
-------L----------------------------------GKTLDL-TYD----GRLS
---D-DQGIPRTGLL-------ILILGVIFMEGNR------APEA---KIWEVLNMI---
-----GVN-AEK----KDFIYGEPRKFITKDLVQE------KYLEYQQV-PNSDPPSYEF
----RWGPRAHAETS--KRKVLEFFCKVTGSDPS----S-FPSLYEE---VLRDDEERAQ
AKLASSAKSGS-------------------------------------------------
------------------------------------------------------------
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--------------------------------------MDPPE-----------------
-----------------NSQS-AN-L-D----------------STQF----ERE-TKD-
-------------LEGAQVP----------------------------------------
------------------------------------------------------------
--------------------------------------RVEA------------------
------------------------------------------------------------
---E-IETVATT----SE------------------------------------------
---------------------------------------------------NG---LDSS
QSAQRTSE---FSAAIN-S--PAEV------------------------P-SVGAPG---
------------G------PVGEAF------------GPDSSRQDMLNSKVIDLI-----
-------LFLLLKYRRKQQTC-KAEIL--YMVIRGYE-----EHFPVIFAKASDC-----
----LRLTFGLE---------IVE-RNPRV---------HSYS-----------------
-------L----------------------------------VHALGL-TYD----GM--
QH-GF-PGVPKTGLL-------IIVLCIIFIEDNC------ASEQ---VLWRILNNV---
-----GLY-AGR----DHFVYGDPGVLITEHFVQE------GYLECRQV-ADSDPPTKEY
----LWGPRAHAETT--KMKLLKFFASIVKQDPK----S-YPTRYAE---ALKDEIERA-
------------------------------------------------------------
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--------------------------------------MPHG-Q----------------
-----------------KSD-SCNLK-E----------------DLQA----PRE-AQG-
-------------LVGLQVPIVEE------------------------------------
-----------------------------------------------------------E
E-AT-----------------------STTN-----------------------------
------------------------------------------------------------
--TSFSSLSPLT----PGS--PEDL---P---------------------TTG-------
----------I--------------------------------------LSLF-------
QSFQIAGS---SSTANT-V--TLSSHQ--------------------------EED----
-----------------PSTLQTPP------------NPESLFTEVLQNKVYDLV-----
-------QYLSIKYATKEPIT-KAEML--ESVIREHK-----DHFPVIFKKACES-----
----LETIFGIE---------VKE-VDPTS---------HSYV-----------------
-------L----------------------------------VKSLDL-TYD----GMLS
---D-DQVMPKTGIL-------ILVLGIIFMEGNR------ASVE---RILEIMNMV---
-----GVH-DGK----NNFIYGDPRKLITEDLVQE------KYLEYQQV-PNSDPPRYEV
----LWGPRAHAETT--KMKVLKFLARINGTDPT----S-FTNLYEE---ALRDEREKAQ
AEVSSDD-TTA-------------------------------------------------
------------------------------------------------------------
-----------------------TT--------D----------------ESS----SV-
------------------------------------------------------------
---------LSS---------------------SFSC-----------------------
------------------PE----------------------------------------
------------------------------------------------------------
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--------------------------------------------------------Y---
PY-QLH---PYPH---C------------CLLSLTSVIMPRGQK---SKIRAREKR-RQA
-RE-----EAQVG-----------------------------------------------
-PQ-------------APAAVAEE------------------------------------
------------------------------------------------------------
--AQ-------------------------ASCSP-----G---------------TKDIA
ESSP-P------------------------AWPPS-------P-------PQGLQR---G
S--STSTPAA-A------------------------------------------------
------------------------------------------------------------
-----------------VP----CTGSEEGT---------------NT-Q-EE-ESA---
-----------------------------KS-AQAQPATAHWLRGPVDMKVAMLV-----
-------HYLLHKYQMKEPIT-KGDML--KNIIQTSK-----SHYPEILKKASHH-----
----LELIFGLD---------VKE-VDTIK---------HTYV-----------------
-------L----------------------------------VNKLEM-SCE----GKTN
----EDRGLPKTGLL-------MTVLGVILTKGNC------ATEE---EVWEVLNLM---
-----GVY-AER----RHFIFGDPKQLLTKDMVQL------NYLEYRQV-PNSNPPCYEF
----LWGPRAHAETT--KMKVLEFLAKIHNTIPS----A-FPLLYEE---AMRDEEERAQ
AR-A--------------------------------------------------------
------------------------------------------------------------
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------------------------------------------

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------------------------------------------------------------
--------------------------------------MPLRHTS---------------
-----------------QLW---KL--------------------EED----PGE-AQG-
-------------LVNAQLPEAED------------------------------------
-----------------------------------------------------------E
DEVSSPPYL------CS-------------------------------------------
------------------------------------------------------------
--------SGLF----FVP--PEEG-----------------------------------
---------SE----------------------------------------TA---WSPP
QSPQSAGP---SPSGRA-P--SGWSQVEF----------------AGPSG-PEEEIW---
------------N------PWEVPE----------YAQPSAQGGDTMLMSGADLV-----
-------GFLLRKYLNKQPTS-QAEVL--EVLSPDMQ-----DAWPEIWGQACEC-----
----MQLVFGVE---------VKE-VDPIA---------HSYV-----------------
-------L----------------------------------VTVLGL-SYD----GMLS
-G--E-QGLPTTGLL-------VLLLGVILLEGDR------APEQ---EVWEALGVM---
-----GVF-AGR----QHVIYGEPRELLTHVWVQE------GYVEYRQV-AGSNPARYEF
----LWGPRAHEETS--KLQVMEYVLWVNSRWPV----S---------------------
------------------------------------------------------------
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------------------------------------------------------------
--------------------------------------------DYGFGMPAFQSVG---
--------TAASP--GSLGLL----------------------------FPPDIQTKTAE
EDNV-LLMHTLL-------AATK--DFLT----VTNKPKK-------------NKTKKAP
IKAI----------SKA-VPV--APSVPNANEIATTKPKITLQALNLSIITQVNQTSAT-
T------------------------------------------------EAAN-------
------TQASSVTTQ----TKMKRVTAKAAQG-FQSATGSEDVSTQLKSPLQVLNLPVIL
QTIQTIQAPSASESAN-------------------------------SH-----------
-------------TAA----------------NKAIFNVTEMSLTPTTTHTA-TIQ--TT
-NDTTNIQATTVSIQTKKAFNAKKTTA--KAINIDTE-------HLEVPDV---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------TEAAT
RQIEA--------------------S---------------------------------V
AAVWPPKSKGEKTANKSP---------N------------SASEISEALLATQMVTNQS-
--------------RAWKA----VTKAWATESQI----QIADQGVQAKMATIQ-TSISAL
ETQ------------AA------------DAVQALADDYLAQL----SLEPTTRIQGKRN
RKS-----------------------------------------------KHLSGDERC-
GSNYKWNPWSRRSSP-PQDVAIL---QESANKLVK------YLLVKD-QRS------P--
------------------------------------------------------------
----SNM---LKDVIQESDKYFPEIIEQASYALEKVK---------GHNLYI-LISTQES
S--------TKDT-PKLG---LLM----------VILSV----------IF--------M
-NGNK----A-VRVSAVIWKVLRKFGLH--PGVRHSLFGEVRKLITDKFVKQK-------
---------YLAYKGVPNSRP---S--EYEFFWGLHSYHETSKMKVLKFACKVQKK---D
------LKDWVAQFWEAVEMEVQAAAMAVA--EAEAR----AEARVQMGIGEEAV-----
------AGP--WNWDDMDIYCLK-REELHSDAQAWR-RFSF----EIEARVQENADASTD
IDFSRGASARAGFNNGASISFSGSLSP--GSGFGGG------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------A
GIAFGGAPSTSTSFSGAASISFGGIPSISTSFSVGASISFGGALS--TSSSFSSEACSGF
GG------------------TI-STTAGFSSALSTSTSFSSAPTTSTIFSGALSTSIGFG
GTLSTSICFGGSPSTIASFGGALSTSICFSDCPSTIAGFSR----GLNTSTNFSSAISTC
IDFGSALSTSVCLDGCPSTS-AGSGNAISTSASLGGTVNTVLAS----------------
----VVHS----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------TPTLALAAGFNEALSTTTD--------------------FGSTHSNS
IGFGGAPSTSLCFGSTSNNNLCFGGPPSTSACFSSATSASFGDGLSTGASFSFGNGLSTS
SGFGSRLGTSTGFHCG--------------------------------------------
----------------------------------------------LGTNTGFGGGLGTS
AGFGSMLGTSAGFSGGFSISDGFGGRPNDSFDRGLSTIIGFGSGSNTSTGFTGESSPSTG
FNSGPSSIVGFSGRPSTVG-----PST-S-------------------------------
----------------------------------DFDGRPSTSGFSSRLSIGAGFGGGP-
STSADFGGK-----------PSTSVGFSSGTTSLGACGFSFG

------------------------------------------------------------
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------------------------------------------------------------
------------------------------MLH---------------------------
----------------------GQKSN-------------------------------PG
--------------------ECEKSQ-PNEGETKV---LSG-------SEAME-QKRCP-
-PL---------------PFF-LGATSQK-KSRAKSRSTRRGPR-R-------------A
---------QCTP---A-------------AAPGPSRKRSHEG-------------AKKK
DEKKQSSSRGKPSAV-KTRKDPL---ADNMDTLVQ------FLLQRY-KMKKLT--KE--
------------------------------------------------------------
----EDM---LEVINKKYKKRFVEIFRRASFSMEVVFGIDVKEVDSTEHTYA-LVSKMNL
PNNGVV-NRGRGL-PKTG---LLM----------TLLGV----------IF--------M
-SGNC----A-R--EERIWKFLNQMRIF--AGKRHFILGEPRKLLTQDFVKLK-------
---------YLEYRQVPNRYP---P--CYEFLWGPRASAETTKMKVLEFLAKINNT---V
------PSAFLGLYEEALRDESERARATEA-EPADPTATAC-----SACSPSRS-SSSCH
--------P---------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------EEEGQGE-----------------
-----------------KEE-E-----------------------KKA----EK--EL--
------------------------------------------------------------
-----------------------------------------------WEEEEG-------
-EK-EEEEE------EE---------------------EEE-------------------
---------------------------------------------------------EEE
EEEKKK--LEKQ----EKQ--EQQEQ-PA-------------------------------
-----SETS------------------------------------------------RPP
QSPQ---R----------S--MAWSTSGG----------------GSSNQ-DSEDTS---
-------------------SLQTSA------------FPESLCRDRIDENVTNLV-----
-------HAMILRYRLRKPIT-KAEML--QVVNKRDK-----SQFSVIFKKACKS-----
----LEVICGID---------VKE-VVPAT---------HSYV-----------------
-------L----------------------------------VNSLDL-TYD----EM--
LS-DP-QSMPKNGLL-------IIILGMIFLEGNC------APEE---DIWEFLNMM---
-----GVY-AGR----EHFIYGEPRNLITRTWVQE------NYLEYQQV-LNSDPPRYQF
----MWGPRAHAETS--KLQVLEFLAKIKGTDPI----S-FSCWYEE---ALRDEQERAQ
ARIGPVGHAAA-------------------------------------------------
------------------------------------------------------------
-----------------------MF------MAQ----------------PLL--P----
------------------------------------------------------------
---------------------------------QRKN-----------------------
------------------EHES--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------

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------------------------------------------------------------
------------------------------------------------------------
--------------------------------------MPRGQK---SKLRAREKC-RET
-HG-----QPQGL-----------------------------------------------
-TG-------------PQATAEKQ------------------------------------
-----------------------------------------------------------E
-ESR-----------------------SSSSSST-----V---------------CRGAR
RRSS----------------------------GSS-------V-------PQESQG---A
P--PTGYPDAGASCSKSDVAA----MGQDEKS------------PSTSRDVSVSQESQ-G
ASPIGPPDAGVSC---------SKS--------DMAAKGQNEKSPSTSRDASV-----PQ
ESQGASPTG---SPDADVS----GSKSDVAA---------------KGQ---DEESL---
-----------------------------SP-SERAAFFTTTHQDPLERKANKMV-----
-------QFLQEKFEKKESIL-KADML--KRVGRQYK-----PCFPEILNRTSEH-----
----LAVAFGVE---------LKE-TDSSG---------ESYT-----------------
-------L----------------------------------VSKLGL-SSE----GILS
----GDNALLKSGLL-------MSLLCVIFMNGNR------ATEE---EVWEFLGVL---
-----GIY-DGI----LHSIYGDARKIITEDLVQD------KYVLYRQV-HNSDPPRYEF
----LWGPRATAETT--KMRVLRVLAESNNTSPG----L-YPHMYED---ALIDEVERAL
RLRA--------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
---------------------------------------MSDT-----------------
---------------SE-SGS----------------------------GLTRFQAEASE
KDSG-SMMQTLL-------TVTQ--NLEVSDTPKAS------------------KA----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------PKVSEVVKVS-------KAPGGS---------------KAT-----------
-------------EV---------------------------SKAPEAQEAA-ATQGSST
-AQLTDTQVVAA----ES--KSPAADS--KTQNADPQ-------AVTMPAA---------
----ETKK-----VSC--------------------------------------------
------------------------------------------------------------
--------------------------------------------------------VA--
-------------------------------EKKV-------------------------
----K-A--KASESET--------PASQAPAEER---------EP--EGAAAPTQENQDT
RPKVK--------------------A---------------------------------K
KARKVKHLDGEEDGN---------------SDQSQASGATAGRRVSKALMASMARRASRG
PIAFWARRAS----RTRLA----A------------------------------------
------------------------------------WARRALL----SLRSPKARRGKAR
RRA---------------------------------------------------------
-AKLQS-SQEPEAPP-PRDVALL---QGRANDLVK------YLLAKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LKDVIKEYTDVYPEIIERAGYSLEKVFGIQLKEIDKNDHLYI-LLSTLEP
TDAGIL-GTTKDS-PKLG---LLM----------VLLSI----------IF--------M
-NGNR----S-S--EAVIWEVLRKLGLR--PGIHHSLFGDVKKLITDEFVKQK-------
---------YLDYARVPNSNP---P--EYEFFWGLRSYYETSKMKVLKFACKVQKK---D
------PKEWAAQYREAMEADLKAAAEAAA--EAKAR----AEIRARMGIGLGSE-----
----NAAGP--CNWD-------------EADIGPWA-KARIQAGAEAKAKAQESG--GAS
ASASTST------STSASTSTGASASA--SSGFSASASLTATLTFGLFAGLGGAGASTSG
SSGACG-FSYK-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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----------------------------------MDRRNDYGYRMPTFQSKHPNGEERT-
GSNYRRIPWGRRPPP-PRDVAIL---QERANKLVK------YLLVKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LKDVIQEYDEYFPEIIERASYALEKMFRVNLKEIDKQSSLYI-LISTQES
SAG-IL-GTICSM-----------------------------------------------
-LG------N-T--SAFIWVVLGMENFS--PGICL--FR-----SKFHFLSPR-------
---------YLEYKRVPNSRP---P--EYEFFWGLRSYHETSKMKVLKFACKVQKK---D
------PKDWAAQYREAVEMDVQAAAVAVA--EAEAR----AEARAQMGIGEEPM-----
------CSFG-IRPHSS-------------------------------------------
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--------------------------MATKDP------------LAMEPPVA-NQS----
----K------GN---------KVKKTPI-QAIIKAP--------STSPTT-V------N
----E-----ITKPKITLQ-ALNLPGITI-S---------------QASA-TT-------
---------EAA----ETTSLVTIQPKV-NKTKQVISKAAHNSYSPTGSEGINTK-----
-------F----------KLK--SLNL--LVISQTIQ-----API----SSESANSAMIV
S-TKSKKASKAK-----KV-TNKA-IAGATETSHVLTATHIATIQG---HVTNTVIQ---
---ATAAFSQT--------KKFSKAKK---------------ITAKVT-NTD----TEPL
----EDPNA-----------------SEVATRQIE------GSAA---TIHPKKSKG---
-----NNI-FHNGSNAPYETSESSESQPATQMVTN----QARAMTLVNR--GSR------
---------AQKADAKSQA-----------------------------------------
------------------------------------------------------------
--------------------------T-------------------------------ES
QTQ------------------IADQGAQVVTASQNNISLETQGLHAAAVQALK-------
------------------------DNKVA-LXX------------X-----XXXX-----
----------XX----------------------X-----XXX-------------XXP-
KH---PNGDGRSVSN-YRIPW---GQRLSPSRNLTILQERANVYLLD-QT---KMPIC--
------------------------------------------------------------
----SDM---LKDVFQEYDEYFPEIIEQVSYALEKIFQVNPKEIDKQSSFYI-LISTQES
S-AGIL-GTTKDT-PKLG---ILM----------VILIF----------VN--------S
N---K----A-S--ESVIWEMLCKFGLH--LGVXXXXXXXXXXXXXXXXXXXX-------
---------XXXXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXXXXKKKKNSK---D
------ITQFQEAVEMKVQT------VAVAVTKAEVKAEARAQMG----MRE--------
---KAMPW-----NDDMDTDCLT-REELGNNIWAWN-IFLL----EIEVRAQENADTSTN
IDFKRGASSRNSFSDGGSISFSGAS-----GGFMGGSG----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------INSGGALNTSTNFSSAANIIFGGTPSTSTSFSS----------------RA
NISFHGVPSTNSSFS-------------------GEANSFGGTPC--INVSFNDGVSCSF
SGPLNTNATFSGRAGSGFGGIFS-TTPGISGAL--------VPTTSTVFSGALSTNAGFG
STLSTNVCFSDSPSSGTSFGG---------------------------------------
------------------------------------------------------------
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--------------------------------------MPRGQK---SKLRARKKR-QQT
-RS-----VAQGA-----------------------------------------------
-KA-------------AHAVGEEE------------------------------------
-----------------------------------------------------------E
-ES--------------------------PSSSP-----V---------------REGTP
PSSP-R-------------------------SCA----------------AQGGLR---G
R--ASSSPEA-G------------------------------------------------
------------------------------------------------------------
-----------------SS----DASSDVDE---------------G-------------
---------------------------------YRAGSSQVSLRDPLNRKASMLV-----
-------QFIMEKYKKREPIV-QADML--KVVKRKYK-----KHFPEILRRTSER-----
----VELIFGLE---------LEE-VDPIS---------RSYV-----------------
-------L----------------------------------INKLSL-SSE---DEV-S
----GERVLPKTGLV-------MTLLAVIFMKGNR------ATEA---EMWEFLNAL---
-----GIY-AGR----RHSIFGEPRKLITEDLVQE------NYLEYRQV-RFRSPPVYEF
----VWGPRAHAETT--KMKVLEVLAKINDTVPR----C-YPDLYEE---ALRDEQERAE
LQ-AVARASTV-AR----------------------------------------------
----------------------------------------------------------SR
--------------------VGS--R-----------------------AKSR-RSSHT-
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--------------------------------------------------------MAE-
----------------------------------------------------------GS
YR-----K-E-------SEGYNVEDMDEGSDEVG--EEDMVEGNDYE----EFGAFGGYG
ALTSFDIRI--LRAFGSLG-----------------------------PGFRILANEPWE
LENP-VLARTLL-------EAFR--MDPETLANETAARAA-------------NVARAAA
---S----------NQA--RAA--------------------ATAARATYNQV---VANH
H------------------------------------------------PVAT-------
------HQASGGDTQPVTSAAQ--AP--------------------AATPETSIASPHSS
------QMLVNSEMAAPGAPAR-SPQPQTSS---------------QAQ-----------
-------------EAA----------------AEGPSTACAFPQASRAGEMD-ATRPKTA
FLGQ----------------------------NDAFD-------FSQPAGV---------
----SGMAE-----PAPAQEA--ATEGPSV---------AS-RGTQAASAGEGAATRPKT
T-----------------------------K-----------------------------
------------------------------------------------------------
--------------------------------------------------------SGKA
LAKTRWVEPQNVVAAG--------GPQGQRGTTS---------IPEPESAAA---TSQQS
AE-----------------------P---------------------------------W
ARMGGKRTKKSKHLDDEY--------ESSE-EEREPPAVPPTWRASQPLLTT--------
---------A----R---------------------------------------------
----------------------------------------PQMA----------------
-----------------PRPS-----------------------------M----A----
-LRSQVPSRHVLCLP-PRNVTLL---QERANKLVK------YLMIKD-YKKIPI--KR--
------------------------------------------------------------
----SDM---LKDVIREYDEHFPEIIERATYTLEKKFGIHLKEIDKEEHLYI-LVCTRDS
SAR-LL-GKTKDT-PRLS---LLL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPFLGDLRKLITEDFVKQK-------
---------YLEYKKVPNSSP---P--EYEFLWGLRACHETSKMRVLRFIAQYQNR---D
------PREWRAHFLEAVDDAFKTMDVDMA--EEHAR----AQMRAQMNIGEEAL-----
------IGR--WSWDDIQVELLT-WDEDGDFGDAWS-RIPF----AFWARYHQYILNSNR
ANRRG------TWRAGVSSGTNGAASASMLDGPSTS-ST---IRTRNAARTS--------
----ASFFSWIQQP----------------------------------------------
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---------------------------------------------------METQIRREG
LGCSPASIKRKKKKEDSG--HLGLQVSTMFSEDDFQST---EGAPSGPQI----------
---------QWSQDLPRVQVFRE----------QANQE---DRSPR-RTQRITGG-EV--
-----------------LWGPITQIFPTVWPADLTGVIMPLEQ-----------------
-----------------RSQ-HCKPE-E----------------GLQA----QED-NPG-
-------------LVGGAQALQAE------------------------------------
-----------------------------------------------------------E
Q-E---------------------------------------------------------
------------------------------------------------------------
---AASFSSTLN----VGT--LEE------------------------------------
---------VP--------------------------------------ATES---PSPP
QSPQGESS---SPTAMD-S--IFGSLSDE----------------GSSS--QEEEGP---
------------S------TSPDLI------------DPESFSQDILHDKIIDLV-----
-------HLLLCKYRVKGLIT-KAEML--GSVIKNYE-----DYFPEIFREASEC-----
----MQLLFGID---------VKE-VDPTS---------HSYV-----------------
-------L----------------------------------VTSLSL-SYD----GIQG
---DE-QSMPKSGLI--------IVLGVIFMEGNC------VPEE---VMWEVLSIM---
-----GVY-AGR----EHFLFGEPKKLLTHDWVQE------KYLVYRQV-PGTDPACYEF
----LWGPRAHAETS--KMKVLEYIANANGRDPS----S-YSSLYED---ALREEEEGV-
------------------------------------------------------------
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--------------------------------------MPRGQE---SKRRAREKR-RQA
-RG-----EDRCL-----------------------------------------------
-RG-------------AQATAAEK------------------------------------
-----------------------------------------------------------E
-KLP-------------------------SSSSP-----A---------------CQSAP
QSFP-A-------------------------AGI----------------PQESQR---A
S--YP-SSPAAA------------------------------------------------
------------------------------------------------------------
-----------------VS----LTSSEEGA---------------KG-Q-KG-ESP---
-----------------------------NS-FQGPSSSESTGRDLLNRKTGELV-----
-------QFLLNKYIRKEPIT-REAML--KVINRTYK-----QHFPEILRRSAEN-----
----VEVVFGLY---------LKE-MDPSR---------QSYV-----------------
-------L----------------------------------VSKLDF-PDQ---GSL-G
----DDGGFPRSGLL-------MVLLSTIFMHGNR------ATEE---EMWECLNAL---
-----GMY-KGR----KHFIYGEPQELLTKDLVRE------GYLEYRQV-PSSDPPRCEF
----LWGPRAHAETS--KMKVLEFVAKLNDTVAS----T-YKSQYEE---ALREEEEQAR
AR-AAARASAR-AR----------------------------------------------
----------------------------------------------------------VS
--------------------RSS--Q-----------------------P----------
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-----------------------------------------RQK---RGRFAQEKR-RQL
-RG-----ESRFL-----------------------------------------------
-KT-------------AQASVAG-------------------------------------
------------------------------------------------------------
--RE-------------------------SVAKP-----Q---------------AEDRS
HNFP-P------------------------IGTSC-------E-------HKVPQE---T
P--ATIGAAS-A------------------------------------------------
------------------------------------------------------------
-----------------IA----CC-SEEGA---------------KS-Q-DV-APP---
------------------------------R-T--SSIPELWRRDPLNKKVILLV-----
-------QFLLQRYQKKEPIT-KADML--KFVIKKYK-----YHFNEIIKRASDH-----
----MELAFGVD---------LKE-VDPIR---------HCYT-----------------
-------L----------------------------------VNKLNL-SSD----GTMN
----DEENMPKTGLL-------MIVLGVIFMKGNC------ASEE---EIWEVLNMM---
-----GVH-ADR----KHFIYGEPRKVITEDLVQL------NYLEYRQV-RHSEPPRYEF
----LWGPKAKAETS--KMRVLEFLAKVHDTVPS----A-FPFWYEE---ALRDEEERAQ
AR-AAARARTT-AV----------------------------------------------
----------------------------------------------------------VS
--------------------VRFRNG-----------------------N-----FYPKQ
------------------------------------------------------------
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-----------------------------MGLNTSRVAITLKPQDPMEQNVAELL-----
-------QFLLVKDQSKYPIR-ESEMR--EYIVKEYR-----NQFPEILRRAAAH-----
----LECIFRFE---------LRE-LDPEA---------HTYI-----------------
-------L----------------------------------LNKLGPVPFE-----GLE
----ESPNGPKMGLL-------MMILGQIFLNGNQ------AKEA---EIWEMLWRM---
-----GVQ-RER----RLSIFGNPKRLLSVEFVCT------CPRIQR-----LDRVQGEV
----I-------------------------------------------------------
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----------------------------------GPNGVYNFSQAHNAKEIP-NTQSKAA
F-------------------KSQNAIP--KGPDTAYD-------FSQAAIT---------
----GELTTNKSEMAFKAQNAT-TKVGPNA---------T-YNFSQSLSANEMANNRPKA
------------------------------------------------------------
----------------------------------------------AFKAWNDTTKASIA
-------------------------------DTQT-----------QNV-----------
----NQV---KMASSQ--------ADIETD--PG---------ISEPDGAAAQTSADGTQ
AQNLE--------------------S---------------------------------R
TIIRGKRTRKXXXXXX---------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXX----XXXXX----XXXXXXXXXXX----X-XXXXXXXXXX-----XXXXX
XXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXX
XXX---XXXXXXXXXX-X----XXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-
-XXXXXXXXXXXXXX-XXXXXXX---XXXXXXXXX------XXXXXXXXXXXXX--XX--
------------------------------------------------------------
----XXX---XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXX----------XXXXX----------XX--------X
-XXXX----X-X--XXXXXXXXXXXXXX--XXVRHPLLGDLRKLLTYEFVKQK-------
---------YLDYRRVPNSNP---P--EYEFLWGLRSYHETSKMKVLRFIAEVQKR---D
------PRDWTAQFMEAADEALDALDAAAA--EAEAR----AEARTRMGIGDEAV-----
------SGP--WSWDDIEFELLT-WDEEGDFGDPWS-RIPF----TFWARYHQNARSRFP
QTFAG---------------------P--IIGPSGTASA------NFAANFGAIGF----
--------FWVE------------------------------------------------
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-----------------------------MGLSTSRVAITLKPQDPMEQNVAELL-----
-------QFLLVKDQSKYPIR-ESEMR--EYIVKEYR-----NQFPEILRRAAAH-----
----LECIFRFE---------LRE-LDPEA---------RTYI-----------------
-------L----------------------------------LNKLGPVPFE-----GLE
----ESPNGPKMGLL-------MMILGQIFLNGNQ------AKEA---EIWEMLWRM---
-----GVQ-RER----RLSIFGNPKRLLSVEFVCT------CPRIQR-----LDRVQGEV
----I-------------------------------------------------------
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------------------------------------------

------------------------------------------------------------
------------------MSQ--LSKNLGDSSPPAEAPKPP-------------------
----------VYSRPTVLMRAP-----PASSRAPPVPWDPPPMDLQAASLAAWQAPQPAW
EPPQGQLPAPV---ASLVQPPALGG-LVQAPPLGGPMGKPPT------------------
---------------PGVLMVQPPPPPGAPMPQPPAPGVLMVHPSATGAPVAHPPP-PGN
PMSHPP-------------------------PPGAPM-----------------------
--------------------------------------------A-------HAPPPGTP
------------------------MAHP--PPPGTPMAHAPPPGTPMVPPPPPGTPMAHP
PPPGTP--MA-------------------HPPPPGTPMAQP---PAPGVLMAQPLTPGVL
MVQPP-------------APGAPMAQPL---PPAALM-------------------SQPP
PSAAPMAKPPGPGVLMIHPSGAGAPITQPPVSG---------------APMAQTVPP---
----PTQPMASWAPQGQPLILQIQSQVI----R-------APPPV---P-----------
-------Q---GPPTPQVQLATTPGWQATAPGWQGPPQGWQATPLTWQATQVTWQAPT--
----------IAWQAPPPI-RQGPPPIRP-------------GPPPIRPGPPPV------
------------------------------------------GRQTPPV-------IRQA
-AP---------V-----------------------------------------------
--------IRQAAPLIRQAPP-PI------------------------------------
-----------------------------------------------------------R
--------------SAPQVLATQPQLWQALPPPP-----P---------------LRQAP
QARLLAPQVQG------------APLVPTAPMLTP-------VPAGPGAGPQVPQP---V
L--PTPLSVP----------------------------------------LPAPLP----
-APQTAPQAAPQASQ-------QAVQ--CPSIIWQAPKGQSPVQHE--------------
------------------------------------------------------------
------------------------------------------------------------
---------LPTSMEFQEVQQ-AQ-EM--AWQAPKVP-----THFWQPLPAQEGQEQ---
----PPSIVQLE-----Q-QPFRGALASQKGLQTQL-PTHEAQPT--GPQAEMPAMQLQS
SWQGPPTMLQAPPGAPVAGENFPRGQAKSLLTP-SGECRASSSEPKGSS-KE----RRTS
SK--EKKGPPKDRM----------IFTGTFCAPRA----MSASRAHLPNAWKNLPTTSGA
FYATSRVF-PST----SHFQP----AFKGPSATTA----SPKSRPLAL---QDPYPCIEA
LPAAPWMLQPNGDVSKSSKAASSIPT-ATEAVPQ----A-SA---TE---ASKT-VDPPR
RS-----------------------GKV--------------------------------
--TRK-----KKHLEPKE-DNRGPRVA-------------------------------SR
--E-WQGS----WSWENSS--PSDW--EFQSSVQ-V--LGDWEGPSTSYGLNGW------
-------------------------EEPSTSWALSSWEGPSTSK-G--------------
---------LGHC---------------EGSGSPQPFTVSEVP-------------C---
LSHRHWASQEDPMEE-TQQLSPL---EERANALVQ------FLLVRD-RAKGPI--LR--
------------------------------------------------------------
----SEM---VNVIIREYKDEYLEIISRANTKLECNFGCQLKEIDSNTHSYV-IVNKLGH
PQCDLW-ASFIDK-PKFG---LLM----------VVLSL----------IF--------M
-KGNC----V-R--ENLIFNFLFRLGLD--VRETNSLFGNMKKLITEVFVRHR-------
---------YLEYRRIPCTEP---A--EYELLWGPRAFLETSKMLVLRFLAKLHNR---D
------PRCWPFHYLEALAEFESEVSDEDE-PDT----SGDT-------GDP--------
---TSRRPPR--------------------------------------------------
------------------------------------------------------------
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------------------------------MPR---------------------------
----------------------GQKSK-------------------------------NR
--------------------SRAKRQ-QARRE------VPEVQP--TAEKAGS--SV---
----------------------DESVGSS-FP---DGSAPQGVK-T-------------P
---------GSFG---A----------------GVSCAGSGIG---------VRNAAGFA
DQKSSDGTQAGASVQ-HTLKDPI---MRKASVLIE------FLLDKF-KMKEAV--TK--
------------------------------------------------------------
----SEM---LAVVNKKYKEHFSEILRRTSARLELVFGLELKEIDASTQSYL-LVGKLGL
STEGSL-SSNWGL-PKTG---LLM----------SILGV----------IF--------M
-KGNR----A-T--VQEVWQFLNGVGVY--AGKKHLIFGEPEAFI-TDLVQEN-------
---------YLAYRQVPSSDP---P--SYEFLWGPRAHAETTKMKVLEVLAKVNGT---V
------PSAFPNLYQLALRDQAEGTKKKSS-RQGC-------------------------
------------------------------------------------------------
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--------------------------------------MPRA-P----------------
-----------------KRR-RYMLE-E----------------GLQS----QSE-TQG-
-------------PVGALLPVAVE------------------------------------
-----------------------------------------------------------E
D-TS-----------------------SS-STCSSSFPSSFPSS----------------
-----------------------------------------------------------S
----SSSCYPLL----LST--PEE--VDD---------------------VTG-------
----------A--------------------------------------PSPP---QSP-
---QSAHP---SPTAMA-S--PPLSQSED----------------DSSSS-RGEEGP---
------------S------TSQAQP------------DTASFPRNVIDGKVAELV-----
-------EFLLVKFHTKEPTT-KAEML--NTVLRDYQ-----DHFPVIFSEASEC-----
----MQLVFGVD---------VKE-VDPSD---------HAYV-----------------
-------L----------------------------------VTTLGL-TYD----GMLS
---GE-QSMPKTGLL-------VMLLGVIHLQGDC------APEE---DVWEALSVM---
-----GVR-AGR----EHFIYGEPRELITKVWVRE------QYVEYRQV-PSSDPAPYES
----LWGPRAHAETS--KMKVLEYLLRVSSRDPN----P-FLHLCEE---AVSDEE----
------------------------------------------------------------
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--------------------------------------MPRGHK---SKLHAREKR-RQT
-QG-----NCSR------------------------------------------------
-----------------------G------------------------------------
-----------------------------------------------------------G
-GSP-------------------------SSSFS-----P---------------FGASP
PSSP-A-------------------------AGI----------------PQRPQ-----
------------------------------------------------------------
------------------------------------------------------------
---SIPPIT---TGAAGAS----GTRAAGGA---------------EG-Q-DE----G--
----------GP-----------------SS-SAAPAPTERSQRDPVTRRVSTLL-----
-------QFLLYKYKMKEPIT-KAEMM--KIINKRHK-----EHFPDILRRASVH-----
----LEVVFGLE---------LKE-VDSKG---------ESYA-----------------
-------L----------------------------------VSHLEI-SKE----ENFI
----GSRGFPKNGLL-------MPLLGMIYRNGDR------ATEE---EMWAFLNVL---
-----GIY-DGK----WHFMFGEPRKLITKDLVQE------KYLEYRQV-PNSDPPRYEF
----LWGPRAHTEAN--KKKVLEFLAKISATDPG----A-FQAVYEE---IWRLKKRETQ
AENA-PGP----------------------------------------------------
-----------------------------------------------------------V
------------------------------------------------------------
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---------------------M-------SLVSQNARH----------------------
------------------------------------------------------------
------------------CSAEIT------------------------------------
-----------------------------------------------------------A
-DY---------------------------------------------------------
-----------------------------------------------------------G
D--GRGEIQA----------------TNASGS------------P-T-------------
---------------------------------------------------SM------L
----------VVDAPQ----CPQAPINSQCV---------------NTSQ-AV-------
---------QDP----N--DLEV--LID-EQSRRLGA---LRVHDPLEDRSIALV-----
-------NFMRMKSQTEGSIQ--QSEM--LEFLREYS-----DQFPEILRRASAH-----
----LDQVFGLN---------LRV-IDPQA---------DTYN-----------------
----------------------L-------------------VSKRGF-QIT----DRIA
----ESLDMPKASLL-------ALVLGHILLNGNR------AREA---SIWDLLLKV---
-----DMW---DKPQRINNLFGNTRNLLTTDFVCM------RFLEYWPV-YGTNPLEFEF
----LWGSRAHR--EITKM-----------------------------------------
------------------------------------------------------------
--------------------------E-------------------------------AL
K-----------------------F---VS----------------DAHDEEP-------
------------------------WSWPE-EYN------------KALEGDKTKER---S
---------------------------------------------------------LT-
AG---L--------E-FWSED---TMNDKANDLVQ------LAISVT-EEMLPI--HQ--
------------------------------------------------------------
----DEL---LAHTGKEFEDVFPNILNRATLILDMFYGLSLIEVDTSEHIYL-LVQQPES
EEEQVM-LESLGR-PTQE---YVM----------PILGL----------IF--------L
-MGNR----V-K--EANVWNLLRRFSVD--VGRKHSI--------TRKLMRQR-------
---------YLECRPLSYSNP---V--EYELLWGPRAHHETIKMKVLEYMARLYRK---R
------PQNWPEQYREAVE-----------DEEARAKSEATIMFF----LDP--------
---T--------------------------------------------------------
------------------------------------------------------------
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---------IQGP-----------------------------------------------
-EV-------------AQVSGAVE------------------------------------
-----------------------------------------------------------A
-PST-------------------------SSSQL-----L---------------MPGNL
SEAP-G------------------------ALTSS-------T-------PSTPED---L
Q--NSYG-----------------------------------------------------
------------------------------------------------------------
------------------S----LIQSSEGS---------------GS-K-EEESVP---
-----------------------------NT-SAMVADPEHVPKSALDEKVAFLV-----
-------NFLLLKYQMKEPAR-KADML--KFIMEDDE-----VRFCEILLRASER-----
----LEMVFGLD---------VKE-MDPIN---------QCYG-----------------
-------L----------------------------------SIKLGL-TYD----GMLS
----DEENIPKTGLL-------ILMLGVIFMKGNR------ATEE---EIWDVLKMT---
-----GIH-RDQ----KHFIFGDARQLIAHDFVNE------KYLEYHQV-ANSDPVQYEF
----QWGPRAHAETS--KMKVLEFLAKVHGTNPR----D-FSAQYEE---ALLEEEERAL
AR-ISIESASS-SL----------------------------------------------
----------------------------------------------------------AT
--------------------ASS--S-----------------------AMGG-SSSSI-
------------------------------------------------------------
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---------------------------------------MDRRNEYGYRMSPFQ--G---
--------PLPPP--GSLGLP----------------------------FPPDVQTETTE
EDS-----------------------------PVANRPKK-------------SKTKKTP
IKVV----------TKV------TPPVPSANEIATHKPKITLQALNLPIITQISQDSAT-
T------------------------------------------------EAAN-------
------IQGPLVSVQPKKANKTKRVTVKAAQS-SQSSVGSEAVTTQLKSPIQALSLPVVS
QSIQA---PIASDSANSLNL-IASTKPKKAS---------------KAK-----------
-------------KAA----------------NKAMTSATEISQALTATHTA-TTQGQII
-SETTNIHATATSIRAKKAPKAKKTTS--KATNTELE-------HVEAPHI---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------TEAAT
RQTET--------------------S---------------------------------A
AAIRPKKAKSKKAANKGL---------N------------SAGEISEAQPTTHMVTNQTL
AATLRVKRGS----RTRKA----AAKGRALESQT----PIADQGTQAKTATSQ-TSMSAL
ETQ------------IA------------AAVQALADDYLAQL----SLEPTARTRGKRN
RKM--------------------------------------------MKAKHPNGDERS-
SSNYRRIPWGRRPSP-PRDVAIL---QERANKLVK------YLLVKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LKDVIQEYDEYFPEIIERASYALEKMFRVNLKEIDKQSSLYI-LISTQES
SAG-IL-GTTKDT-PKLG---LLM----------VILSV----------IF--------M
-NGNK----A-S--EAVIWEVLRKLGLR--PGVRHSLFGEVRKLITDEFVKQK-------
---------YLEYKRVPNSRP---P--EYEFFWGLRSYHETSKMKVLKFACKVQKK---D
------PKDWAAQYREAVEMEVH-------------------------------------
---------------DMDIDCLT-REELGDDAQAWS-RFSF----EIEARSQENTDANTN
IDFSRGASTRSSFSDGASVSFSGAPSP--SGGFSG-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------GAGITFGGAPCTSASFSSAASISFGSIPSTSNTFTGGASISFGGAPST
SASFSSA----------------------------------------------------A
SISFGGAPSTITSFSGGASISFGGAPSTSTSFSSTASISFGGAPS--TSTSFSGGASISF
GGTPCTSASFNSGASSGFGSTL-STTAGFGGALTTSTSFSSAPATSTVFSEALTTSTGFG
GTLSTSVCFGGSPSSGASFGGTLSTSICFGGSPTASTGFGG----TLSTSVSFGGCSSTS
ADFGGTLSTSVCFGGSPGTN-VSFGGALSS-ASFGGALNSSASCDGALNTS---------
-------------------------------------ASASFGGTVSTSAGFGSALNPNT
SFGGVLNSTTGFDGALNTSASFGGAVSTSASFGGTLNTSAG-------------------
------------------------------------------------------------
--FGSALNNSAGFVGAVSTSAGF-------------------------------------
-------------GGTLS-SAGFGNALNTSAGFGGAVSTSAGFGGAL-TSAGFGSAISTS
ASFSGTPSTNPGFGGAFSSSAGFS---T-TTDFGGSPSNSIGFGGAPSTSISFGGAHSTS
LCFG-APSTSLCFGSASNTNLCFGGPPSTSACFSGVTSASFSDGPSNSAGFSFGSGLSTS
AGFGG-LSTSA----------GFGGSLGTSAGFSGGLGTSTGFDGSLGTAAGFSGGLSTS
SGFSGGLGTSTGFGGGLGTSAGFGGGLGTSAGFSGGLGTSAGFGGGLVTSDGFGGGLGTN
AGFGSTLGTSAGFSGGLSTSDGFGGGPNASFDRGLSTIIGFGSGSNTSTGFTGEPSTSAG
FSSGPSSIIGFSGGPGTGAGFCSGQGT-SGFGGGPSTRAGFSGLSTGA-GFGSGPN----
------------------------------------------------------------
--SAGFGGGPSTGPGFSGG-PSTDAGFGGGATSLGACGFSYG

------------------------------------------------------------
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---------------------------------------MSDT-----------------
---------------SE-SGA----------------------------GLTSFQAEASE
KDSS-SMMQTLL-------TVTQ--NVEVPETPKAS------------------KA----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------PEVSEDVKVS-------KTSGVP---------------KAT-----------
-------------EV---------------------------SKTPEAQEAP-ATQASST
-TQLTDTQVLAA----EN--KSLAADT--KKQNADPQ-------AVTMPAT---------
----ETKK-----VSC--------------------------------------------
------------------------------------------------------------
--------------------------------------------------------VA--
-------------------------------DTKV-------------------------
----N-T--KAQETEA--------AASQAPADEP---------EP--ESAAAQSQENQDT
RPKVK--------------------A---------------------------------K
KARKVKHLDGEEDGS---------------SDQSQASGTTGGRRVSKALMASMARRASRG
PIAFWARRAS----RTRLA----A------------------------------------
------------------------------------WARRALL----SLRSPKARRGKAR
RRA---------------------------------------------------------
-AKLQS-SQEPEAPP-PRDVALL---QGRANDLVK------YLLAKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LKDIIKEYTDVYPEIIERAGYSLEKVFGIQLKEIDKNDHLYI-LLSTLEP
TDAGIL-GTTKDS-PKLG---LLM----------VLLSI----------IF--------M
-NGNR----S-S--EAVIWEVLRKLGLR--PGIHHSLFGDVKKLITDEFVKQK-------
---------YLDYARVPNSNP---P--EYEFFWGLRSYYETSKMKVLKFACKVQKK---D
------PKEWAAQYREAMEADLKAAAEAAA--EAKAR----AEIRARMGIGLGSE-----
----NAAGP--CNWD-------------EADIGPWA-KARIQAGAEAKAKAQESG--SAS
TGASTST------NNSA--SA--SAST--SGGFSAGASLTATLTFGLFAGLGGAGASTSG
SSGACG-FSYK-------------------------------------------------
------------------------------------------------------------
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--------------------------------------MPLR-Q----------------
-----------------QIE-LHKIE-D----------------EPED----PAE-AQD-
-------------LVETQLHWVSS------------------------------------
-----------------------------------------------------------S
------------------------------------------------------------
------------------------------------------------------------
-------YSVLF----LET--LEEE---A---------------------DPE-------
----------T--------------------------------------PSPP-------
QDPQGVCP---SPAP-VAP--TPLSQSKD----------------DASGS-QDDEGP---
------------S------PSHDQE------------HADASQSGSLHLKVADLV-----
-------EFLLLKYCAKEPTT-QAEML--SVVLRDAQ-----DHFPEVLSQASEL-----
----IQLVFGLD---------VKE-VDPSE---------HTYA-----------------
-------L----------------------------------VPTLGL-TWD----GVLS
---DG-QSLPKTGLL-------VVLLGVILLKGEC------APEE---EVWGALGKM---
-----GVC-AGR----EHCIYGEPRELLTQVWVQE------GYLEYHQV-PHSNPAHYEF
----LWGPRAHAETS--KLQVLEHMLRVSERDPR----S-FLSLSEE---AVIEEEGS--
------------------------------------------------------------
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------------------------------MPR---------------------------
----------------------SKKSK-------------------------------AR
--------------------GGDKCP-QAQGKTQS---CGGAQAIATAEEEST--TSSL-
---------------------QCEDITQS-LPGAESCSTSRERQ-R-------------V
---------PTIT-----------------TTALFSYTRSCEA-------------FNGQ
S KYRALAYEVPPFTE-TPGTDCL---TRKPSLLEQ------FLLYKY-NMKQLM--MK--
------------------------------------------------------------
----EDI---LNIIHQSHHDRFAEILKRASERIELVFAVDLKEVDSVVPCYN-LISKLKL
PNNGRV-RGGRGL-PKTG---LLM----------NLLGM----------IF--------L
-KGNC----A-A--EEDIWKYLDTMRVY--AGRKHFIFGEPRKLITKDLVRLK-------
---------YLEYRQVANSDP---P--RYEFLWGPKAHLETSKMKVLEFLAKVNDA---V
------PSDFPTYYEEALQDEEEKAQGMHA-ARPDTNVKVSIPPRDMLNIII-PPIRQ--
------TAAT-NYFGIVDKLEKN-------------------------------------
------------------------------------------------------------
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---------------------------------------MPRRK---SKLRTRERR-CQA
-QS-----GTQGL-----------------------------------------------
-TG-------------AQATAAEE------------------------------------
-----------------------------------------------------------E
-AA--------------------------SSSCP-----S---------------LGVTT
RRKP-G------------------------AKSRS-------T-------LKSPQR---A
L--ATTTNPA-G------------------------------------------------
------------------------------------------------------------
-----------------VS----PARSNKGA---------------KG-Q-MK-KKH---
-----------------------------SS-SQAPVSAVRSRKGPLRRTASVLV-----
-------QFLVHMYKMKKPVR-KAHML--KFIAKKYQ-----NRFPEILRRASFS-----
----MEMLFGVD---------LKE-VDRTK---------HTYT-----------------
-------F----------------------------------VSKMAL-PND----GTMS
----RGSGLPKTGLL-------MYILAVILMKGNC------ATEE---NIWEFLNKM---
-----RVY-AGK----RHFIFGEPKKLITQDWVKL------KYLEYRQV-ANSDPARYEF
----LWGPRAHAETS--KMKVLEFLAKVNHTVPS----A-FQSWYEE---ALKDEEERAQ
------------------------------------------------------------
----------------------------------------------------------AS
--------------------GCSSVL-----------------------SSS---SHT--
------------------------------------------------------------
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----------SKHLDDEY--------ESSE-EEREPPAVPPTWRASPPSLT---------
---------V----R---------------------------------------------
----------------------------------------AQLA----------------
-----------------PRPP-----------------------------L----A----
-PRSQIPSRHVLCLP-PRNVTLL---QERANKLVK------YLMIKD-YKKIPI--KR--
------------------------------------------------------------
----SDM---LKDVIREYDEHFPEIIERATYTLEKKFGIHLKEIDKEEHLYI-LVCTRDS
SAR-LL-GKTKDT-PRLS---LLL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPFLGDLRKLITDDFVKQKNPGLTEG
APLSVAHSWYLEYKKIPNSNP---P--EYEFLWGLRARHETSKMRVLRFIAQNQNR---D
------PREWKARFLEAVDDAFKKMDVDMA--EEHAR----AQMRAQMNIGDEAL-----
------IGR--WSWDDIQVELLT-WDEDGDFGDAWA-RIPF----AFWARYHQYILNSNR
ANRRA------TWRAGVSSGTNGGASTSVLDGPSTS-ST---IRTRNAARAG--------
----ASFFSWIQHR----------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
--------------------------------------MPRGQK---SKLRAREKR-RKA
-RE-----ETQGL-----------------------------------------------
-KV-------------AHATAAEK------------------------------------
-----------------------------------------------------------E
-ECP-------------------------SS-SP-----V---------------LGDTP
TSSP-A-------------------------AGI----------------PQKPQG---A
P--PTTTAAAA-------------------------------------------------
------------------------------------------------------------
-----------------VS----CTESDEGA---------------KC-Q-GE-ENA---
-----------------------------SF-SQATTSTESSVKDPVAWEAGMLM-----
-------HFILRKYKMREPIM-KADML--KVVDEKYK-----DHFTEILNGASRR-----
----LELVFGLD---------LKE-DNPSG---------HTYT-----------------
-------L----------------------------------VSKLNL-TND---GNL-S
----NDWDFPRNGLL-------MPLLGVIFLKGNS------ATEE---EIWKFMNVL---
-----GAY-DGE----EHLIYGEPRKFITQDLVQE------KYLKYEQV-PNSDPPRYQF
----LWGPRAYAETT--KMKVLEFLAKMNGATPR----D-FPSHYEE---ALRDEEERAQ
VR-SSVRARRR-TTAT--------------------------------------------
--------------------------T-------------------------------FR
--------------------ARS--R-----------------------APFS-RSSHPM
------------------------------------------------------------
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------MLFGLD---------LKE-VDPTN---------HCYG-----------------
-------I----------------------------------FIKSGL-TYD----GMMH
----GEAGVPKTGIL-------ILILGVIFMKGNH------ATEE---EVWEVLNVT---
-----GLY-SGK----KHFIFGEPKQLITEDFVRE------GYLEFRQV-ASADPAQSEF
----LWGPKAHAETT--KMKVLEFIAKVHGTDPS----S-FPSQYEE---ALQDEKEKAQ
ARIS-AKCLYH-SKF---------------------------------------------
------------------------------------------------------------
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------------------------------------------

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--------------------------------------MSLG-Q----------------
-----------------KSE-CCKLE-E----------------DLQA----PKE-AQG-
-------------LECVQAPMAQK------------------------------------
-----------------------------------------------------------E
E-AT-----------------------SCP------------------------------
------------------------------------------------------------
KSTISSSLTPLI----PGT--TEEV---P---------------------ATG-------
----------A--------------------------------------LSAV-------
QSSQGACF---SPTATS-A--TPLSQTDE----------------N-SRS-QLEEEP---
------------SI------SQTPP------------DPESSLSGELNNKVAELM-----
-------QFLCVKYVTKEPIT-KAEML--RSVIREHK-----ENFPEIFSKVCEC-----
----MEVVFGIE---------VKE-VDPTG---------HSYE-----------------
-------L----------------------------------VKTLNL-TYD----GMLS
---N-DGGMPKTGFL-------ILILGMIFMEGNC------APEE---KIWKALNTM---
-----GVY-AGQ----EDFIYGEPRKLITKDLVEE------QYLQYRQV-PHSDPPRYEF
----LWGPRAYAETS--KMKVLEFFAKISGTDPT----S-FLFWYEE---ALRDER--AQ
ARTAPGDDTTG-------------------------------------------------
------------------------------------------------------------
-----------------------HG--------Q--------------------------
------------------------------------------------------------
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--------------------------------------MPRGKK---SKLRAHEKR-HQA
-RE-----EPENL-----------------------------------------------
-VG-------------VQATEGVR------------------------------------
-----------------------------------------------------------E
-EFR-------------------------SSSSL-----P---------------LKSLP
AAGS-----------------------------YS-------N-------PQGPQR---A
T--STATTTA-A------------------------------------------------
------------------------------------------------------------
-----------------VS----YTRSNEGA---------------KD-Q-VE-ERP---
-----------------------------RS-SQAQPITEPFHRGPLDEKVVTLV-----
-------HYLLYKYKMKEPIT-KADML--RKVIQTHR-----NHFHQLLKRASEH-----
----LELVFGLD---------MKE-VDPNR---------HIYI-----------------
-------L----------------------------------VNKLEG-SYD----GRLS
----DDRGVPKTGLL-------MTVLGVIFTKGNC------ATEE---QVWQTLNVI---
-----GLY-EGR----KHFIFGEPRKLITKDLVKE------NYLEYRQV-PNSDPACYEF
----LWGPRAHAETS--KMKVLEFLAKVHNTVPS----A-FPFWYEE---ALRDEEERAR
AR-AAATAHTA-AT----------------------------------------------
----------------------------------------------------------AS
--------------------VHS--S-----------------------AMAR-ARSRAM
DGT---------------CSR-AM------------------------------------
------------------------------------------------------------
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--------------------------------------MSRY------------------
----------------GKHP-RLSLE---------------EGVNFQN----PTE-TDD-
-----------DDVVFPVLPTAEKDEREGEEEVLKEDE-DGN-----KQETEED------
---NVEKEDEDEE----KEK---------------------------EEEKEESGDEVNE
EEDET----------RE-EEDISSMILSSSNISLAAFSPPSPSS---------------S
---SSS---------------------------------------S-------I-F---S
SSSSSSSLFSLF----QSN--LVENE----------------------------------
---------GF--------------------------------------AIGM---LGLF
QNAQSFFP---LP--------TLGGNLDE----------------AAGYQ-VES--S---
------------G------VIASPE------------DPDSLLDTVIQEKATDLV-----
-------FLFIYKYRVKEPIT-LTEMH--EVVTKEYE-----NHFPVIFIEASKC-----
----LEMTFGID---------IKE-SDLVS---------SAYV-----------------
-------L----------------------------------VNSLNL-TYE----DTLS
---DS-DRLPRNAFL-------IVILGVIFIEGNC------ASED---RIWEFLKLV---
-----GVY-DGE----EHFICGDPREFLTIHLVQQ------NYLEYREV-PNSQPPCFEF
----LWGPRAYAETT--KMKVLEFLAKMNGCDPS----D-FSIWYEE---ALRDEEERAW
ALNDSANTSPN-------------------------------------------------
------------------------------------------------------------
-----------------------AW------FVE----------------R---------
------------------------------------------------------------
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-----------------------------------------------------MSEQSKD
LSD---------------------------------------------------------
------------------------------------------------------------
--------PNF----------------------------A---------------AEA-P
SSEV--------------------------QSS-----------------PGVPAG---V
P--PS----AT----------LAEPQSPPLGP------------T---------------
----AAPQAA--------------------------------------------------
------PPP--------------QAPSDEDD---------PKAL-LEA-A-EE--GR---
----------------------AHQAP----SAAQPG-PAPPAPAQLVQKAHELM-----
-------WYVLVKDQKKMIIW-FPDMV--KDVIGSYK-----KWCRSILRRTSLI-----
----LARVFGLH---------LRL-TSLHT---------MEFA-----------------
-------L----------------------------------VKALEPEELD-----RVA
----LSNRMPMTGLL-------LMILSLIYVKGRG------ARES---AVWNVLRIL---
-----GLR-PWK----KHSTFGDVRKLITEEFVQQ------NYLKYQRV-PYVEPPEYEF
----FWGSRASREIT--KMQIMEFLARVFKKDPQ----A-WPSRYRE---ALEEARALRE
ANPTA----------------------------------HCPRNSVSED-----------
------------------------------------------------------------
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---------------------------------------MSET-----------------
---------------SE-SGV----------------------------GPTRFQGKASE
KDSG-SVMQDLL-------PVTQ--NLEVSETPKAE------------------KA----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------PESSEAAKVP-------KASGNP---------------KAT-----------
-------------EV---------------------------SKAPEAPEAA-ATQPSTT
-TQLTDTQALAA----EN--KSPAADT--KTPKADLQ-------AMTMPAT---------
----QTKK-----VSC--------------------------------------------
------------------------------------------------------------
--------------------------------------------------------VT--
-------------------------------DPKV-------------------------
----S-T--KAPETEA--------ADSQAGADEP---------EP--EGAAVQVQENQDT
RPKVK--------------------A---------------------------------K
NTQKVKHVDGEEDGNSD---------------QSQASETTAGRRVSKALMASMARRASRG
PIAFWARRAS----RTRLA----A------------------------------------
------------------------------------WARRALL----SLRSPRARRGKAR
RRA---------------------------------------------------------
-AKLQSVSQEPEAPP-PRDVALL---QGRANDLVK------YLLAKD-QTKIPI--RR--
------------------------------------------------------------
----SDM---LKDIIKEYTDVYPEIIERAGYSLEKVFGIQLKEIDKSDHLYI-LLSTLEP
TDAGIL-GTTKDS-PKLG---LLM----------VLLSI----------IF--------M
-NGNR----S-S--EAVIWEVLRKLGLR--PGIHHSLFGDVKKLITDEFVKQK-------
---------YLDYARVPNSNP---P--EYEFFWGLRSYYETSKMKVLKFACKVQKK---D
------PKEWAAQYREAMEADLKAAAEAAA--EAKAR----AEIRAQMGIGLGSE-----
----NAAGP--CNWD-------------EADIGPWA-KARIQAGAETKAKA--QESGGAS
AGASTG----TSVGTGGSA--SASAGA--SGGFSTSSNLTATLSFGLFAGLSGAGASTSS
SSGACG-FSYK-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------

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------------------------------------------------------------
--------------------------------------MSLEQ-----------------
-----------------RSQ-HCKPE-E----------------GLEA----QEA-ALG-
-------------LVGAQAPATEG------------------------------------
-----------------------------------------------------------Q
E-A---------------------------------------------------------
------------------------------------------------------------
----AASSSTLV----EVT--LGE------------------------------------
---------VP--------------------------------------AAGS---PSPP
QGPQGAST---FPTTR--------------------------------------REP---
------------S------TSPDL---------------ESMFLAALSRKVAELV-----
-------HFLLLKCQAGELVT-KAEML--ECVIPDCM-----YFFPVIFRKASDS-----
----LQLIFGID---------VME-INPTC---------NLYI-----------------
-------L----------------------------------VTCLGL-SYD----GLLG
---DD-QIMPKTGLL-------ILVLDMIATEGNC------APEE---KIWKELSAM---
-----EVF-DGR----EHSVFAEPRKLLTQDLVQE------NYPEYRQL-RGSDSACYEF
----LWGPRALLETS--YMKVLQHMLSTSGGRHI----S-YLSLHEL---ALRQGEE---
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----------------------------------------MSQ-----------------
-----------------SSE-ECAAD-Q----------------G-QT----CEE-TQK-
-------------LQVAAAS----------------------------------------
-------------------------------------------------------V---N
VEEP----------------------------CSSSHLMAT------------------S
LKDQTS---------------------------------------EET------QVSKDV
EEPCSS-SQLLM----ASN---QD------------------------------------
---------DP--------------------------------------EDET---PSTS
RGLQHPSD---SSSESA-E--DLGNQEVQ----------------SNP-------VI---
------------P------PD--QS------------DSTDLPVMTIDGKVDFLV-----
-------NYMLYKYQVKEMMS-MHDIM--TLIVKEDK-----DHFHDILMRASER-----
----MEMVFGLD---------VKE-VDPVN---------HCYA-----------------
-------L----------------------------------FIKLGL-TYD----GM--
RN-DE-YSFPKTGLL-------ILILGVVFMKGDS------ATEE---EIWEVLNPM---
-----GIY-AGM----THFMFGDPRELITDEFVRE------QYLAYQPI-ANSDPIQYEY
----VWGLRAKAETS--KMRVLEFVAKVHGSDPT----A-FPSQYEE---ALIEEEERTF
TMLLEHGGLSS-------------------------------------------------
------------------------------------------------------------
-----------------------T-------SCE----------------SSS--D----
------------------------------------------------------------
---------TSS---------------------NF-------------------------
------------------SHV---------------------------------------
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--------------------------------------MPRGRK---SKLRAREKR-RQA
-RG-----EKQGL-----------------------------------------------
-ES-------------AEATAAG-------------------------------------
------------------------------------------------------------
GGIS-------------------------SSANL-----F---------------SKDTI
QNSP-A------------------------SVTPD-------T-------PKVPQK---V
P--STANTTA-A------------------------------------------------
------------------------------------------------------------
-----------------VS----YNSSDEDV---------------NS-Q-PE-GSP---
------------------------------N-S--STSTESLHKDPLNKKVVLLV-----
-------QFLLQKYQKKELIT-KADML--KFVVKKYK-----SQFNEILKRASDH-----
----MELAFGVD---------LKE-VDPIR---------HRYT-----------------
-------L----------------------------------VSKLDI-AID----GLIS
----DEESMPKTGLL-------MIVLGVIFMKGNC------APEE---DVWEVLNMM---
-----GVY-ADR----KHFIYGEPKKVITEDLVQL------KYLEYRQV-PNSDPLRYEF
----LWGPRAQEETS--KMKILEFLARVHGTIPT----A-FPSLYEE---ASKDEEERAQ
AR-AAARARTA-AM----------------------------------------------
----------------------------------------------------------AS
--------------------ARS--R-----------------------TLAS-GFSHAK
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--------------------------------------------------MLQKPR---S
R--------------------------------------------------GRFSS----
-------PAE----------------------------KDRDSGRGG-------------
-DVRAHRGGVSEE----------TPSTSRGP---------------AG------------
---------------------SSSQGA--RR-SQAAPTVGPRTQKQLELKVAELV-----
-------QFLLIKDQKKIPIK-RTDIL--KHVIGDYK-----DIFPDLLKLAAER-----
----LQYVFGYK---------LVE-LEPKS---------NTYI-----------------
-------L----------------------------------INTLEPVEED----AEVR
----GDQGTPTTGLL-------MIVLGLIFMKGNT------IKET---EVWDFLRRL---
-----GVY-PTK----KHLIFGDPKKLITEDFVRQ------RYLEYRRI-PHTDPVDYEF
----QWGPRTNLETS--KMKVLKFVAKVHNQDPK----D-WPAQYCE---ALADEENRAR
PEPS-GPTPS--S-----------------------------------------------
------------------------------------------------------------
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------------S---C-L-QS-------L----TTAIMPRGQK---SKHRACEKH-RQA
-RA-----ETQGL-----------------------------------------------
-HD--------------QATTSGG------------------------------------
-----------------------------------------------------------E
-ETT-------------------------SSSPP-----D---------------SESAP
SSSS-A-------------------------AGT----------------SKGPQG---A
Q--GTTSAAAGA------------------------------------------------
------------------------------------------------------------
-----------------AA----RSRSGVGV---------------EG-Q-VR-EGE---
-----------------------------NS-SQASAAAESSHTDLLTWKAEVLV-----
-------QYMLCKYKMRALIK-RSEML--KAVTRRYR-----EQFPEILSRASER-----
----MELVFGLV---------LKE-VRPNS---------HCYT-----------------
-------L----------------------------------VSNLDL-SDS---ESM-R
----GDWGLPKNGLL-------MPLLGVIYLNGNH------APEE---KIWKFLNML---
-----GIY-DGR----SHFIFGEPRKLITEDLVRE------GYVEYRQV-PGSDPPRYEF
----LWGPKLLTETS--KTKVLQFLAKVKDSGHT----A-FLPQNEE---AWREEVE---
------------------------------------------------------------
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------------------MQAPNAPGLPAAMPGPDVPEGPVDPQILQ-GLCAP-------
---EG-----------------PGT------------SMPSI------------------
---------------PGEGPRT---------AVPPAAS---KGSSASGPPTV-SEG-PNI
ALSIAA---------------S-AL----PNNPLPPTAS---------------------
-----EGPSASEHPFVTEGLN------TSEL-----------------------------
----------------------------PLSNEGPSTSVPPTS--------GEGPSTSVP
PTASEGPSIS-------------------VPPTSGEERSTV-------VP--PAVSEGPG
INVASLSREGPS--------TS-----------------------------------TPR
T------VSEGPSTSVPPTPGEGPSTSVLPTAF---------------EGPSTS------
------------------------------------------------------------
------------------------------------------TLPPSDEGP---------
------------------------SIFI--------------------------------
------------------------------------------------------------
----------RPI----------------------------------------------P
GDGPSTS-------------LALT------------------------------------
-----------------------------------------------------------A
FQEP------------------------VASLPP-----P---------------SGNSS
NI-SGLH-TPW------E-GPS-TSRMSN-AAE-GL--G---T-SGM---PT-APE----
N--PGALLSA--------------------------------------------------
-------------SA-----SGSQNSSQCS-VALPDLGGAKA------------------
------------------------SADSEGP---------------K-------------
-------GAEGPLEFQVLRDHENSNSITIMGLGTAQVALTLKPQDPMEQNVAELL-----
-------QFLLVKDQSKYPIR-ESEMR--LHIAKEYR-----SQFPEILRRAAAH-----
----LECIFRFE---------LRE-LDPEQ---------RTYI-----------------
-------L----------------------------------LNKLGPVPFE-----GLE
----DSPNGPKMGLL-------MMILGEIFLNGNQ------AKEA---EIWEMLWRM---
-----GVQ-RER----RLSIFGNPKRLLSVEFVWQ------RYLDYRPI-TDCTPVEYEF
----FWGPRSHLETT--KMKILQFMAKIYNKDPM----D-WPEQYNE---ALEEDAIRDA
ADD---------------------------------------------------------
------------------------------------------------------------
----WQAVPHFRRPFFEE----------IPAD------------------LLS-PD----
-SD---------------------------------------------------------
---------VSGY-------------------------P---------------------
---------SKYPPH-SWPESRM---ESKSRKLVQ------LFLLMD-STKLPI--PK--
------------------------------------------------------------
----KGI---LYYIGRECSKVFPDLLNRAARTLNQVYGTELVVLDPRNHSYT-LYNRREM
EDAEEI-MDSPNR-PGNN---FLM----------QVLSF----------IF--------I
-MGNH----A-R--ESAVWAFLRGLGVQ--TGRKHVI--------TCRYLSQR-------
---------YIDSLRVPDSDP---V--QYEFVWGPRARLETSKMKALRYVARIHRK---D
------PQDWPEQYREAMEDEANRADAGRR-QF----------LIQNVR-----------
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--------------------------------------MPRGHK---SKLRAREKC-HQA
-KG-----DTHSV-----------------------------------------------
-DG-------------AQAIAAEE------------------------------------
-----------------------------------------------------------K
-GSP-------------------------SSSSP-----P---------------FGGSP
PSSP-A-------------------------AGI----------------PQGPQS---I
P--PITSAA-AG------------------------------------------------
------------------------------------------------------------
-----------------AS----GTRAAGRA---------------EG-Q-DE-GGP---
-----------------------------SS-SAAPAPTERSQRDPITRRVSTLL-----
-------QLLLYKYKMKEPIT-KAEMM--KIINERYK-----EHFPDILRRASVH-----
----MEVVFGLD---------LKE-VDSKG---------QSYA-----------------
-------L----------------------------------ISKLEI-SKE---ENF-I
----GDRGFPKNGLL-------MPLLGMIYRNGNR------ATEE---EMWEFLNVL---
-----GVY-DGK----WHFMFGEPRKLITKDLVQE------EYLEYRQV-PNSDPPRYEF
----LWGPRAHTEAN--KKKVLEFWAKISATDPS----A-FQALYEE---IWRLKKRETQ
AE-NV-------------------------------------------------------
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--------------------------------------MPLEQ-----------------
-----------------RSQ-HYKPE-E----------------RLEA----RGE-ALG-
-------------LVGAQASATEE------------------------------------
-----------------------------------------------------------Q
E-T---------------------------------------------------------
------------------------------------------------------------
----PSSSSTVV----EVT--RGE------------------------------------
---------VP--------------------------------------AS---------
---SGAST---LPTTIS-Y--TLWSQSDE----------------DSSN--QEEEGP---
------------S------AFSDL---------------ESSFQAALSRKVAE LV-----
-------HFLLLKYRAREPVT-KAEML--ESVMRNCQ-----YFFPVIFSKASDS-----
----LQLVFGIE---------LME-VDPIG---------HLYI-----------------
-------F----------------------------------VTCLGL-SYD----GLLG
---DN-QIMPKTGLL-------IILLA-IAKEGDC------APEE---KIWEELSVL---
-----EVF-EGR----EHSIFADPRKLLTQDFVQE------NYLEYWQV-PGSDPACYEF
----LWGPRALVETS--YVKVLYHMLKISGGPHF----S-YSPLHKW---ALGDGEE---
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----------MLHLSPGLWVSIVQLLPTLLPAVLTRVSLPLEQ-----------------
-----------------RSQ-HCKPE-E----------------GLEA----RGE-ALG-
-------------LVGAQVPVTEE------------------------------------
-----------------------------------------------------------Q
E-T---------------------------------------------------------
------------------------------------------------------------
----ASSSSTLV----EVT--LGE------------------------------------
---------VS--------------------------------------AAD------PQ
----GAST---LPTTNN-Y--TPWSQSDE----------------DSSS--QEEEGP---
------------S------TFPDL---------------ESGFQAALSRKVAELV-----
-------HFLLLKYRARERVT-KAEML--E-----------SYFFPVIFSKASEY-----
----LQLVFGIE---------VME-VVPVG---------HLYI-----------------
-------L----------------------------------VTCLGL-SYN----GLLG
---EN-QIMPTTDLL-------IIILATVAIEGDG------APEE---KVWEELSVL---
-----ELS-GRR----EDSVLANPSKLLTQVLVQE------NYLEYRQV-PFSDHACYEF
----LWGPRALVETS--YVKVLYHMLKITGEPQI----S-YPPLHEW---AWREGEE---
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---------------------M-------SLVSQNARR----------------------
------------------------------------------------------------
------------------CNAEIT------------------------------------
-----------------------------------------------------------A
-DY---------------------------------------------------------
-----------------------------------------------------------S
D--GRGEIQA----------------TNASGP------------P-T-------------
---------------------------------------------------PM------L
----------VVDVPQ----CPQAPINPQCV---------------NTSQ-AV-------
---------QDT----N--DLEV--LID-EQSRRLGA---LRVHDPLEDRSIALV-----
-------NFMRMKSQKEGSIQ--QSEM--LEFLREYS-----DQFPEILRRASAH-----
----LDRVFGLN---------LRV-IDPQA---------DTYN-----------------
----------------------L-------------------VSKRGS-QIT----DRIV
----ESLDMPKASLL-------ALVLGHILLNGNR------AREE---SIWDLLLKV---
-----DMW---DKPQRINNLFGNTRNLLTTDFVRM------RFLEYWPV-YGTNPLEFEF
----LWGSRAHS--EITKM-----------------------------------------
------------------------------------------------------------
--------------------------E-------------------------------AL
K-----------------------F---VS----------------DAHDEEP-------
------------------------QSWPE-EYN------------KALEADKTKER---S
---------------------------------------------------------LT-
AG---L--------E-FWSED---TMNDKANDLVQ------LAISVS-EELLPI--HQ--
------------------------------------------------------------
----DEL---LAHTGKEFEDVFPNILNRATLILDMFYGLSLIEVDTSEHIYL-LVQQPES
EEEQVM-LESLGR-PTQE---YVM----------PILGL----------IF--------L
-MGNR----V-K--EANVWNLLRRFSVD--VGRKHAI--------TCKLMRQR-------
---------YLECRPLSYSNP---V--EYELLWGPRAHHETTKMKVLEYMARLYRK---R
------PQDWPEQYREAVE-----------DEEARAKSEATTMFF----LGP--------
---M--------------------------------------------------------
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--------------------------------------MSHLQ-----------------
-----------------KSP-ECEAD-P----------------G-QT----FEE-TQG-
-------------LRVAAVS----------------------------------------
-------------------------------------------------------Y---D
TGEP----------------------------CSSSHFMAS------------------S
LKDQTC---------------------------------------EETQGLEIKQVSRDV
EEPGPS-SYSLM----ATN---QD------------------------------------
---------DL--------------------------------------ADQI---PSTS
GGL--------------------SDQENQ----------------GNP-------VN---
------------P------PC--QP------------DTTNTPVMSIDSKVDFLV-----
-------NYMLYKYQMKEIMS-MTDIL--KLIVKEDE-----DRFPEILMRATER-----
----MEMVFGLD---------VKE-IDPVN---------HCYA-----------------
-------L----------------------------------FIKLGL-TYD----GM--
RS-DQ-YSFPKTGLL-------ILILGIVFMKGNR------STEE---EIWEVLNPM---
-----GIY-AGM----NHFVFGDPRQLITDEFVRE------QYLTYQPV-ANSDPVQYEY
----VWGPRTRAETS--KMKVLEYVAKVHGTDPI----A-FRSQYEE---ALIEEEERAL
TMILDRAGSSS-------------------------------------------------
------------------------------------------------------------
-----------------------L-------SGA----------------SSG--A----
------------------------------------------------------------
---------MGS---------------------SF-------------------------
------------------PDI---------------------------------------
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------------------------------------------------------GDERS-
GSNY-------RPHH-PRDVAIL---QERANKLVK------YLLVRT-KDP--H--QA--
------------------------------------------------------------
----LRC---AEGCHPECEEYYPEIMN------EQMFRVNLKEIDKQSSLYI-LISNQES
STG-IL-GTTKES-PKLG---LLM----------VLLSI----------IF--------M
-NGNR----S-S--GAVIWEVLRKLGLR--PGVKHSLFGEVRKLITDEFVKQK-------
---------YLEYKRVPNSRP---P--EYEFFWGLRSYHETSKMKVLKFACKVQKK---D
------PKDWASQYREAVEMEVQAAAVAVA--VAEAEARAEVYS----------------
--------PH-LQ--IPLMNCN--SPSHGVKIHPWN-LCPH----ISLSSHDQTAEDDM-
------------------------------------------------------------
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------------------------------------------

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-----------------------------------------TL--------GEGLGTTVP
PTFSEESGIS-------------------VPLPSNEGLSTP-------VS--PTISEGPG
INVPSPASEAPS--------TS---SP-----SGLH-------------------I----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------LGKGP---------------SISGL
H--------SL------REGPN-TSQMPLAAEGRGA--S---A---M---ST--------
---------------------------AADTP----------------------------
------A--AVSCGA-----SAGMNLFKCTSLGLPK------------------------
-----------------------ASAPSVRP---------------K-------------
-------RSEGPLEFQVLRDSENSNSITIMGLGTAHVALTLKPQDPMEQNVAELL-----
-------QFLLVKDQSKYPIK-ESEMR--EFIVKEYR-----HQFPEILRRAAAH-----
----LECIFRFE---------LKE-LDPEE---------RTYI-----------------
-------L----------------------------------LNKLGPVPYD-----GLE
----DIPNGPKMGLL-------MMILGKIFLNGNQ------AREA---DIWEMLWRF---
-----GVQ-RER----RLSVFGNPKRLLSVEFVWQ------RYLDYRPI-TDCGPVEYEF
----YWGPRSHIETT--KMKILRFMARIYNKDPM----D-WPEQYNE---ALEEDALRNA
EDD---------------------------------------------------------
------------------------------------------------------------
----WRPVAPFRRPFFEE----------VPPE------------------LLA-PD----
-SD---------------------------------------------------------
---------APGY-------------------------S---------------------
---------SKYSPH-SWPESRL---ESKSRKLVQ------LFLLMD-STKLPI--PK--
------------------------------------------------------------
----KGI---LYYIGRECSKVFPDLLNRAARTLNHVYGTELVVLDPRNHSYT-LFNRREM
EDTEEI-VDSPNR-PGNN---FLM----------QVLSF----------IF--------I
-MGNH----A-R--ESAVWAFLRGLGVQ--NGRKHVI--------TCRYLSQR-------
---------YIDSLRVPDSDP---V--QYDFVWGPRARLETSKMKALRYVARIHRK---E
------PQDWPEQYREALEEEANRADAGNR-AL----------VVRNFRR----------
------------------------------------------------------------
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--------------------------------------------------MLQKPR---G
R--------------------------------------------------GRPSK----
-------QAD----------------------------PERDWGGA--------------
----------CEE----------GPSTSRGA---------------GGSS-Q--------
------------------GSR---------A-SLSAPTVGPRTQKQLELKVAELV-----
-------QFLLIKDQKKIPIK-RTDIL--KHVVGDYR-----DVYPNLLKLAAER-----
----LQYVFGYK---------LVE-LEPKS---------HTYI-----------------
-------L----------------------------------TNMLEPVEAD----AEVR
----GDQGTPISGLL-------MIVLGLIFMKGNT------ITET---EVWDFLRRL---
-----GVY-PTK----KHLIFGDPKKLITEDFVRQ------RYLEYRRI-PHTDPVDYEL
----QWGPRTNLETS--KMKVLKFVAKVHNQDPK----D-WPAQYCE---ALADEESRAR
PAAP-SAPATSS------------------------------------------------
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--------------------------------------------------------MAE-
----------------------------------------------------------GS
YR-----V-Q-------PGNSSVEDMDEGGSQVR--EEEMVGGNEYE----EFGAFGGYG
TLTSFDIHL--LRAFDTLG-----------------------------SGLHILSNEPWE
LENP-VLAQTLV-------EALQ--LDPDTLANETEARAA-------------NIARSAA
---S----------NRA-SRAA--------------------AAAARRAFTQV---VANH
L-------------------------------------------------VTP-------
------PQAPGVDAQPRTHAE---AQ--------------------QATPETTLASPQTP
------LVLVNSEVAR-----ATSTQSPAAS---------------LAQ-----------
-------------EVA----------------VEGPSTACAFSQAPSAREMD-VTPPQTA
FLDK----------------------------KDVFD-------FTQPAGV---------
----SGMAFPCPKRPASVPEA--TTGGSST---------AS-SVPLATPAREEAALQPKT
T-----------------------------R-----------------------------
------------------------------------------------------------
--------------------------------------------------------SGKA
LAKTRWVEPPNVTSAA--------AAKA-KMATS---------IPEPEGAAA---TAQQG
TE-----------------------P---------------------------------W
ARMGGKRTKKSKHLDDEY--------ESSEEEEREPPVAPPTWRVLQPPLT---------
---------V----Q---------------------------------------------
----------------------------------------AQLA----------------
-----------------PEPP-----------------------------M----G----
-SRSQIPSRHVLSLP-PRNVTLL---QERANKLVK------YLMIKD-YKKIPI--KR--
------------------------------------------------------------
----SDM---LKDVIREYDEHFPEIIERATYTLEKKFGIHLKEIDKEEHLYI-LVCTRDS
SAR-LL-GKTKDT-PRLS---LLL----------VILGI----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPFLGDLRKLITDDFVKQK-------
---------YLEYKKIPNSSP---P--EYEFTWGLRACHETSKMRVLRFIAQNQNR---D
------PREWKAHFLEAVDDAFKTMDLDMA--EEHAR----AQMRAQMNIGNEAL-----
------IGR--WSWDDIQAELLT-WDEDGDFGDAWA-RIPF----AFWARYHQYILNTSR
ANRRA------TWRAGVSSGTNVGASTSLLDGPSTS-ST---IRTRNAARAG--------
----ASFFSWVQ------------------------------------------------
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-------------MEFQEVQQ-TQ-AL--AWQAQKAP-----THFWQPLPAQEAQRQ---
----APPMVQLE-------QPFQGAPPSQKAVQIQL-PPQPPQTT--GPQAELPTLQLQP
SWQTPPAVLQAQPGPPLAAANFPLGSAKSLMTP-SGESRASSIDRRASS-KE----RRTS
SK--ERRAPSKDRM----------IFAATFCAPKA----VSAARAHLPATWKNLPATPET
FAPSSSVF-PAT----SQFQPASLNAFKGPSAASE----APKSLPYAL---QDPFACVEA
LPAVPWAPQPNMNASKASQAVPTLLM-ATAAAPQ----A-TATT-QE---ASKTSVEMPR
RS-----------------------GKA--------------------------------
--TRK-----KKHLEARD-DSRGHTLA-------------------------------FH
--D-WQGP----RPWENLN--LSDW--EVQSPVQ-V--LGDWEHPNTPRGLSGWEGPSTS
-RI---------------LSG---WEGPSTSWALSAWEGPSTSR-A--------------
---------LGLS---------------ESPRSPLPLVVSEVA-------------G---
VSPGSSATQDNSKVE-AQSLSPL---DERANALVQ------FLLVKD-QAKVPV--QR--
------------------------------------------------------------
----SEM---VKVIIREYKDECLDIISRANNKLECAFGYQLKEIDTKNHAYI-IINKLGY
PTGDLV-ASYLDR-PKFG---LLM----------VVLSL----------IF--------M
-KGNC----V-R--EDLIFNFLFKLGLD--VRETNGLFGNTRKLITEVFVRQK-------
---------YLEYRRIPYTEP---A--EYEFLWGPRAFLETSKMLVLRFLAKLHKK---D
------PRCWPFHYLEALAECEWEDTDEDE-PDS--S--DSA-------RGP--------
---TSRPPP---------------------------------------------------
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-----------------------------------------------------MSEQSKD
LSD---------------------------------------------------------
------------------------------------------------------------
--------PNF----------------------------A---------------AEA-P
SSEV--------------------------HSS-----------------PGVPEG---V
P--PS-----ET---------LAEQQSPPLGP------------T---------------
----AAPQAA--------------------------------------------------
------QPP--------------QAPSDEDD---------PKAL-QQA-A-EE--GR---
----------------------AHQAP----SAAQPG-PAPPAPAQLVQKAHELM-----
-------WYVLVKDQKKMIIW-FPDMV--KDVIGSYK-----KWCRSILRRTSLI-----
----LARVFGLH---------LRL-TSLHT---------MEFA-----------------
-------L----------------------------------VKALEPEELD-----RVA
----LSNRMPMTGLL-------LMILSLIYVKGRG------ARES---AVWNVLRIL---
-----GLR-PWK----KHSTFGDVRKLITEEFVQQ------NYLKYQRV-PYVEPPEYEF
----FWGSRASREIT--KLQIMEFLARVFKKDPQ----A-WPSRYRE---ALEEARALRE
ANPTA----------------------------------HCPRSSVSED-----------
------------------------------------------------------------
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--------------------------------------------------MLQTPE---S
R--------------------------------------------------GLPVP----
-------QAE----------------------------GEKDGGHDGETRAPT-----A-
-SQE-------------------RPKEELGA---------------GREE-G--------
----------------AAEPALTRKGA--RA-LAAKALARRRAYRRLNRTVAELV-----
-------QFLLVKDKKKSPIT-RSEMV--KYVIGDLK-----ALFPDIIARAAEH-----
----LRYVFGFE---------LKQ-FDRKH---------HTYI-----------------
-------L----------------------------------INKLKPLEEE----E---
EEEDLGGDGPRLGLL-------MMILGLIYMRGNS------AREA---QVWEMLRRL---
-----GVQ-PSK----YHFLFGYPKRLIMEDFVQQ------RYLSYRRV-PHTNPPEYEF
----SWGPRSNLEIS--KMKVLGFVAKLHKKEPQ----H-WPVQYRE---ALADEADRAR
AKAR-AEASMRARA--------SARA------G---------------------------
------------------------------------------------------------
-IH----L------W---------------------------------------------
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FFF---------------------------------------------------------
------------------------------------------------------------
--------FFF----------------------------E---------------TE---
-SRS--------------------------VTQ-----------------AG---V---P
W--P------D----------LSSLQAPPPGF------------T---------------
----PFSCLS--------------------------------------------------
------L------------------------------------------------PG---
----------------------SWDYR----RRHLPG-PAPPAPAQLVQKAHELM-----
-------WYVLVKDQKKMIIW-FPDMV--KDVIGSYK-----KWCRSILRRTSLI-----
----LARVFGLH---------LRL-TSLHT---------MEFA-----------------
-------L----------------------------------VKALEPEELD-----RVA
----LSNRMPMTGLL-------LMILSLIYVKGRG------ARES---AVWNVLRIL---
-----GLR-PWK----KHSTFGDVRKLITEEFVQQ------NYLKYQRV-PYVEPPEYEF
----FWGSRASREIT--KLQIMEFLARVFKKDPQ----A-WPSRYRE---ALEEARALRE
ANPTA----------------------------------HCARSSVSED-----------
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--------------------------------------HRHH-H----------------
-------------TRNH-----RRRR-E----------------RHRA----ERE-VQG-
-------------PAGAQGPSAQE------------------------------------
-----------------------------------------------------------E
--EA-----------------------AASS-----------------------------
------------------------------------------------------------
--------SAVV----PGT--PEEV---P---------------------AGA-------
----------I--------------------------------------ASPP---QS--
--PPRASS---SHTGLA-S--PPGGDSNE----------------G-SSS-QGAEGP---
------------S------ALQEPE------------NRESLLREAIEDKIADLI-----
-------HLLLFKYRMKEPIT-KEEML--NSVIRDYR-----DHFSEIFSEASDC-----
----MQLIFGVD---------VKE-VEPAS---------HCYV-----------------
-------L----------------------------------ITSVGL-TYQ----EELN
---DE-HYLPKVGLL-------IMILGLIFMENNC------APEE---AIWDSLRIM---
-----GVE-ADR----EHYIYQEPRKLITHDWVQE------GYLVYQPV-PQSDPVRYEF
----LWGPRARAETT--KMKVLEYVSKVNGTDCR----A-FPRLYEE---ALRDEEGGE-
------------------------------------------------------------
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------------------------------------------

------------------------------------------------------------
------------------MSQ--LSKNLGDSSPPAEAPKPP-------------------
----------VYSRPTVLMRAP-----PASSRAPPVPWDPPPIDLQA-SLAAWQAPQPAW
EAPPGQLPAPV---APMVQPPALGGPIVPAPPLGGPMGKPPT------------------
---------------PGVLMVHP-PPPGAPMAQPPTPGVLMVHPSAPGAPIAHPPP-PGT
PMSHPP-------------------------PPGTPMPH---------------------
-----P---------P------------------PPGTPM----V-------HPPPPGTP
------------------------MAHP------------PPPGTPMAHPPPPGTPMAHP
PPPGTP--MA-------------------HPPPPGTPMAQP---PAPGVLMAQPLTPGVL
MVQPA-------------PPGAPMAQPP----PAAVM-------------------TQPP
PSGAPMPKPPGPGVLMIHPPGVRAPMTQPPASG---------------APMVQPAAP---
----PAQPMASWAPQGQPLILQIQSQVI----R-------APPQV---P-----------
-------QVPQVPQAPPAQLATPPGWQATSPGWQATPQGWQATPLTWQTTQVTWQAPA--
----------IAWQAPPPM-RQGPPPIRP-------------SPPPIRPGPLPVR---QA
PPVIRQ---APPVIRQAPP-VIRQA--------------PPVIRQAPPVIRQAPPVIRQA
-PP---------V-----------------------------------------------
--------IRQAPPLIRQAPP-PI------------------------------------
-----------------------------------------------------------R
--------------PAPQVMATQPPLWQPLPPPP-----P---------------LRQAP
QARLPAPQVQA------------APQVPTAPPATQ-------VPAAPPAGPQVPQP---V
L--PAPLSAP----------------------------------------LSA-------
----------P-----------QAVP--CPSIIWQAPKGQPPVPHE--------------
------------------------------------------------------------
------------------------------------------------------------
---------MPTSMEYQEVQQ-TQ-AL--AWQAPKAP-----THFWQPLPAQEAQRQ---
----PPPMVQLE-------QPFQGGPPSQKAVQIQL-PPQQAQAS--GPQAELPTLPIQP
PWQAPPAVLQAQPGAPVAASNFPPGCAKSLMTP-SGECRASSIDRRGSS-KE----RRTS
SK--ERRAPSKDRM----------IFAATFCAPKA----VSAARAHPPGSWKSLPAAPET
FAASSRVF-PAT----SQFQPASLNSFKGPSAASE----TPKSLPYAL---QDPFACVEA
LPAVPWVPQPNMNASKASQAVPTLLM-ATAAAPQ----A-AATT-QE---ASKTSIEPPR
RS-----------------------GKA--------------------------------
--TRK-----KKHLEAEE-NSRGHTLP-------------------------------FH
--D-WQGP----RPWEN----LSDW--EVQSPVQ-V--LGDWERPNTPRGLSGWEGSSTS
-RM---------------LSG---WEGPSTSWALSAWEGPSTSR-A--------------
---------LGFS---------------EGSGSPLPLIVSEVP-------------S---
VSPGSSATQHDSKVE-ARPLSPL---DERANALVQ------FLLVKD-QAKVPV--QR--
------------------------------------------------------------
----SEM---VKVIIREYKDECLDIINRANSKLERAFGYRLKEIDTKSHAYI-VINKLSY
PIGDLV-ASYLDR-PKFG---LLM----------VVLSL----------IF--------M
-KGNC----V-R--EDLIFHFLFKLGFD--VRETNGLFGNMKKLITEVFVREK-------
---------YLEYRRIPYTEP---A--EYEFLWGPRAFLETSKMLVLRFLAKLHKK---D
------PQSWPFHYLEALAECEWEDTDEDE-PDT--GDSD---------HDP--------
---ASRPPPR--------------------------------------------------
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--------------------------------------MPRGQK---SKLRAREKR-RQA
-RE-----ETQDL-----------------------------------------------
-ES-------------TQAPAAEE------------------------------------
-----------------------------------------------------------K
-ESL-------------------------CCSSS-----V---------------LGDAA
PRSP-A-------------------------AGS----------------PQEPKS---A
P--PITTAAAAG------------------------------------------------
------------------------------------------------------------
-----------------DS----HKKSNKGA---------------KR-Q-SK-KNI---
-----------------------------RS-SEAPSAIENLEKDPLNRKAVMLV-----
-------QFLLYKYKMQEPIR-KGDMQ--KVVNRRYK-----EDFPEILKRASER-----
----IELIFGLE---------LKE-TDPRG---------QSYA-----------------
-------F----------------------------------VIKPDL-TDD---GDV-S
----SGLAFPRKGLL-------MPLLGVIFLNGNQ------ATEE---EIWEFLNIL---
-----GVY-DGE----KHFIFGEPRKLITEDLVQE------QYLEYCEV-PNSHPPRYQF
----LWGPRAHAETS--KMRVLEFLAKVNDTIPR----A-FPSSYEE---ALRDEEERAQ
------------------------------------------------------------
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----------------------------------MDRRNDYGFRVPTFQSKHPNGEERT-
GGSFRRIPWGRRPPP-PRDVAIL---QERANKLVK------YLLVKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LKDVIQEYDEYFPEIIERASYALEKMFRVNLKEIDKQSSLYI-LISTQES
SAG-IL-GTTKDT-PKLG---LLM----------VILSV----------IF--------M
-NGNK----A-S--EAVIWEVLRKLGLR--PGVRHSLFGEVRKLITDEFVKQK-------
---------YLEYKRVPNSRP---P--EYEFFWGLRSYHETSKMKVLKFACKVQKK---D
------PKDWAAQYREAVEMDVQAAAVAVA--EAEAR----AEVCYVCYPCLQVT-----
------LAAV-LPME--------------------P-MCSF----GIFVRTAA-------
------------------------------------------------------------
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---------------------------------------MSDT-----------------
---------------SE-SGA----------------------------GLTRFQAEASE
KDSS-SMMQTLL-------TVTQ--NVEVPETLKAS------------------KA----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------LEVSEDVKVS-------KASGVS---------------KAT-----------
-------------EV---------------------------SKTPEAQEAP-ATQASST
-TQLTDTQVLAT----EN--KSVAADT--KKQNADPQ-------AVTMPAT---------
----ETKK-----VSH--------------------------------------------
------------------------------------------------------------
--------------------------------------------------------VA--
-------------------------------DTKV-------------------------
----N-T--KAQETEA--------APSQASADEP---------EP--ESAAAQSQENQDT
RPKVK--------------------A---------------------------------K
KARKVKHLDGEEDGS---------------SDQSQASGTTGGRRVSKALMASMARRASRG
PIAFWARRAS----RTRLA----A------------------------------------
------------------------------------WARRALL----SLRSPKARRGKAR
RRA---------------------------------------------------------
-AKLQS-SQEPEAPP-PRDVALL---QGRANDLVK------YLLAKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LKDIIKEYTDVYPEIIERAGYSLEKVFGIQLKEIDKNDHLYI-LLSTLEP
TDAGIL-GTTKDS-PKLG---LLM----------VLLSI----------IF--------M
-NGNR----S-S--EAVIWEVLRKLGLR--PGIHHSLFGDVKKLITDEFVKQK-------
---------YLDYARVPNSNP---P--EYEFFWGLRSYYETSKMKVLKFACKVQKK---D
------PKEWAAQYREAMEADLKAAAEAAA--EAKAR----AEIRARMGIGLGSE-----
----NAAGP--CNWD-------------EADIGPWA-KARIQAGAEAKAKAQESG--SAS
TGASTST------NNSA--S--ASAST--SGGFSAGASLTATLTFGLFAGLGGAGASTSG
SSGACG-FSYK-------------------------------------------------
------------------------------------------------------------
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---------------------------------------MAQKMDCGAGLLGFQA-----
--------------------------------------------------------EASV
EDSA-LLMQTLM-------EAIQ--IS-EAPPTNQA--TA--------------------
------------------------------------------A-----ASPQSSQPPTA-
N------------------------------------------------EMAD-------
------IQVSAAAARPKS------------------------------------------
-----------------------------AF---------------NVQ-----------
-------------NAT----------------TKGPNGVYDFSQAHNAKEVP-NTQPKAA
F-------------------KSQNATP--KGPNAAYD-------FSQAATT---------
----GELAANKSEMAFKAQNAT-TKVGPTA---------T-YNFSQSLNANDMANNRPKT
------------------------------------------------------------
----------------------------------------------PFKAWNDTTKAPTA
-------------------------------DTQT-----------QNV-----------
----NQT---KMATSH--------ADIETD--PV---------ISEPDGATAQTSADGSQ
AQNLE--------------------S---------------------------------R
TIIRGKRTRKINNLNV---------EENSSGDQRWAPLAAGTWRSAPVPVTT-QNPPGAP
PNVLWQTPLA----WQNPS----GWQNQTARQTP----P-ARQSPPARQTPPAWQNPVAW
QNPVIWPNPVIWQNPVIWPNPI-VWPGPVVWPNPLAWQSPPGWQTPPGWQTPPGWQGPPD
WQG---PPDWPLPPDW-PLPP-DWPLP-TDWPLPPDWIPADWPIPPDWQNLRPSPNLRP-
-SPNSRASQNPGAAQ-PRDVALL---QERANKLVK------YLMLKD-YTKVPI--KR--
------------------------------------------------------------
----SEM---LRDIIREYTDVYPEIIERACFVLEKKFGIQLKEIDKEEHLYI-LISTPE-
SLAGIL-GTTKDT-PKLG---LLL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPLLGDLRKLLTYEFVKQK-------
---------YLDYRRVPNSNP---P--EYEFLWGLRSYHETSKMKVLRFIAEVQKR---D
------PRDWTAQFMEAADEALDALDAAAA--EAEAR----AEARTRMGIGDEAV-----
------SGP--WSWDDIEFELLT-WDEEGDFGDPWS-RIPF----TFWARYHQNARSRFP
QTFAG---------------------P--IIGPGGTASA------NFAANFGAIGF----
--------FWVE------------------------------------------------
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--------------------------------------MPRKHK---NKHHAHGKC-HQV
-RE-----DTQEA-----------------------------------------------
-QA-------------SAAAAPGE------------------------------------
-----------------------------------------------------------E
-CP--------------------------SSPSS-----V---------------PQGSP
PSFS-A-------------------------AGN----------------RQELQG---A
M--APSSPDA-E------------------------------------------------
------------------------------------------------------------
-----------------AS----CAGSDQGA---------------QG-P-KE-ESA---
-----------------------------DA-ARAALLARSIRKDPLMRKASMVM-----
-------DFLLERYTKKEPIT-KNAML--NVIGRKYK-----EHFPEILSRASER-----
----VELVFGLE---------LKE-VDCSR---------NIYA-----------------
-------L----------------------------------VNKFTL-GVE---EGS-S
----DEEALPKSGLL-------MALLGVIFMKGNR------ATEE---EIWDFLNVL---
-----GIY-AGR----KHSIFGEPRKLITKDLVQK------GYLNYRQV-PNSDPPLYEF
----LWGPRSYAETN--KMKVLEVLAKIQDTVPS----S-FPDLYDE---ALRDQAFRAG
LR-GIPISPAM-AE----------------------------------------------
----------------------------------------------------------AS
--------------------APS--R-----------------------AKSY-SSSHI-
------------------------------------------------------------
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------------------------------------------

------------------------------------------------------------
------------------MSQ--LSKNLGDSSPPAEAPKPP-------------------
----------VYSRPTVLMRAP-----PASSRAPPVPWDPPPIDLQA-SLAAWQAPQPAW
EAPQGQLPAPV---VPMTQPPALGGPIVPAPPLGGPMGKPPT------------------
---------------PGVLMVHP-PPPGAPMAQPPTPGVLMVHPSAPGAPMAHPPP-PGT
PMSHPP-------------------------PPGTPMAH---------------------
-----P---------P------------------PPGTPM----A-------HPPPPGTP
------------------------MAHP--PPPGTPMVHPPPPGTPMVHPPPPGTPMAHP
PPPGTP--MA-------------------QPPPPGTPMAQP---PAPGVLMAQPLTPGVL
MVQPA-------------APGAPMVQPP----PAAVM-------------------TQPP
PSGAPMAKPPGPGVLMIHPPGARAPMTQPPASG---------------APMAQPAAPPAQ
PMAPPAQPMASWAPQAQPLILQIQSQVI----R-------APPQV---P-----------
-------Q---GPQAPPAQLATPPGWQATSPGWQATPQGWQATPLTWQTTQVTWQAPA--
----------IAWQVPPPVLRQAPPVIRQ-------------APPVIRQAPPVIR---QA
PPVIRQ---APPVIRQA--------PPVIRQAPPVIRQAPPVIRQAPPVIRQAPPVIRQA
-PP---------V-----------------------------------------------
--------IRQAPPLIRQAPP-PI------------------------------------
-----------------------------------------------------------R
--------------PAPQVLATQPPLWQALPPPP-----P---------------LRQAP
QARLPAPQVQA------------APQVPTAPPATQ-------VPAAPLAGPQVPQP---V
L--PAPLSAP----------------------------------------LSA-------
----------P-----------QAVH--CPSIIWQAPKGQPPVPHE--------------
------------------------------------------------------------
------------------------------------------------------------
---------IPTSMEFQEVQQ-TQ-AL--AWQAQKAP-----THFWQPLPAQEAQRQ---
----APPMVQLE-------QPFQGAPPCQKAVQIQL-PPQPPQTS--GPQAELPTLQLQP
SWQTPPAVLQAQPGPPLAAANFPLGSAKSLMTP-SGESRASCIDRRGSS-KE----RRTS
SK--ERRAPSKDRM----------IFAATFCAPKA----VSAARAHLPGTWKNLPATPET
FAPSSSVF-PAT----SQFQPASLNAFKGPSAASE----APKSLPYAL---QDPFACVEA
LPAVPWPPQPNMNASKASQAVPTLLM-ATAAAPQ----A-TATT-QE---ASKTSVEMPR
RS-----------------------GKA--------------------------------
--TRK-----KKHLEARE-DSRGHTLA-------------------------------FH
--D-WQGP----RPWENLN--LSDW--EVQSPVQ-V--LGDWEHPNTPRGLSGWEGPSTS
-RI---------------LSG---WEGPSTSWALSAWEGPSTSR-A--------------
---------LGLS---------------ESPRSPLPLVVSEVA-------------G---
VSPGSSATQDNSKVE-AQSLSPL---DERANALVQ------FLLVKD-QAKVPV--QR--
------------------------------------------------------------
----SEM---VKVIIREYKDECLEIINRANNKLECAFGYQLKEIDTKSHAYI-IINKLGY
PTGDLV-ASYLDR-PKFG---LLM----------VVLSL----------IF--------M
-KGNC----V-R--EDLIFNFLFRLGLD--VRETNGLFGNTRKLITEVFVRQK-------
---------YLEYRRIPYTEP---A--EYEFLWGPRAFLETSKMLVLRFLAKLHKK---D
------PRCWPFHYLEALAECEWEDTDEDE-PDS--S--DSA-------RGP--------
---TSRPPPR--------------------------------------------------
------------------------------------------------------------
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---------------------------------------------------METWVRREG
LRCSPASIKRKKKREDSG--YLGLQVSTMFSEDDFQST---ERAPYGPQIQ---------
---------QWSQDLARVQVFRE----------QANQE---DRSPR-RTQRITGGEEV--
-----------------LWGPITQMFPTVWPADLTRVIMPLEQ-----------------
-----------------RSQ-HCKPE-E----------------GLQA----QEE-DLG-
-------------LVG-AQALQAE------------------------------------
-----------------------------------------------------------E
Q-E---------------------------------------------------------
------------------------------------------------------------
---AAFFSSTLN----VGT--LED------------------------------------
---------VP--------------------------------------AAES---PSPP
QSLQEESS---SPTAMA-A--IFGSLSDE----------------GFSS--QGKEGP---
------------S------TSPDLI------------DPESFSQDILHDKIIDLV-----
-------HLLLRKYRVKGLIT-KAEML--GSVIKNYA-----DYFPEIFREASAC-----
----MQLLFGID---------VKE-VDPTS---------HSYV-----------------
-------L----------------------------------VTSLNL-SYD----GIQC
---NE-QSMPKSGLL-------IIVLGVIFMEGNC------IPEE---VMWEVLSIM---
-----GVY-AGR----EHFLFGEPKKLLTQDWVQE------KYLVYRQV-PGTDPACYEF
----LWGPRAHAETS--KMKVLEYIANANGRDPT----S-YPSLYED---ALREEGEGV-
------------------------------------------------------------
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--------------------------------------MPRP-R----------------
-----------------KRR-RCMVE-G----------------QPEA----QSG-TEG-
-------------QMSAAVSIE-E------------------------------------
-----------------------------------------------------------D
S-SS-----------------------SSSSTYSSSFPSSFSST----------------
-----------------------------------------------------------S
------SSYALT----SGN--SEEG--C--------------------------------
----------A--------------------------------------ASRA---SSPS
HSPPGAGS---SCTAMI-S--SPRSQVS-------------------ADS-EGEETP---
------------D------SSQALQ------------CGTSLSTGEIDVKVDELV-----
-------KYLLFKYLMKEPVS-KAEIL--SNIIRNYQ-----DHFAVIFREASEC-----
----MQLVFGLE---------LKE-IDPDG---------HTYI-----------------
-------L----------------------------------TIALEL-TYD----GMMT
---DV-QGIPKTGLL-------IMVLSIIFMEGNC------ISED---MVWGILNNI---
-----GLY-AGN----EHFIYGEPRKLITDNFVQE------GYLEYRQV-PGSHPPSYEF
----LWGPRAYAETS--KMKILIFLTSINGSDPR----S-YPVWYAE---ALRDEEQQE-
------------------------------------------------------------
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--------------------------------------MPRGQK---SKLRAREKR-QRT
-RG-----QTQDL-----------------------------------------------
-KV-------------GQPTAAEK------------------------------------
-----------------------------------------------------------E
-ESP-------------------------SSSSS-----V---------------LRDTA
SSSL-A-------------------------FGI----------------PQEPQR---E
P--PTTSAAAA-------------------------------------------------
------------------------------------------------------------
-----------------MS----CTGSDEGD---------------KS-Q-DE-ENA---
-----------------------------SS-SQASTSTERSLKDSLTRKTKMLV-----
-------QFLLYKYKMKEPTT-KAEML--KIISKKYK-----EHFPEIFRKVSQR-----
----TELVFGLA---------LKE-VNPTT---------HSYI-----------------
-------L----------------------------------VSMLGP--ND---GNQ-S
----SAWTLPRNGLL-------MPLLSVIFLNGNC------AREE---EIWEFLNML---
-----GIY-DGK----RHLIFGEPRKLITQDLVQE------KYLEYQQV-PNSDPPRYQF
----LWGPRAHAETS--KMKVLEFLAKVNDTTPN----N-FPLLYEE---ALRDEEERAG
AW-PRVAARRG-TIAM--------------------------------------------
--------------------------T--------------------------------S
--------------------AYS--R-----------------------ATSS-SSSHPM
------------------------------------------------------------
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--------------------------------------MPRRK-----------------
-----------------KSP-PCTP-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------D
QHLQTQ---------------------------------------SETQGLENAQVTNAA
EEALPSSSLLPM----SGN--LKE------------------------------------
---------AP--------------------------------------AAKV---LSAP
EGPQSFCS---SSGDST-A--TSSSKPDE----------------GTRSK-EEKKSL---
------------T------TAVAAA------------NPENVLIDALDRKVAFLV-----
-------NFLLVKYQMKELIR-KADIW--EMIIKDDE-----DHFHEIFLRASER-----
----MEMIFGLD---------VKE-VEPTR---------HCYD-----------------
-------I----------------------------------SIKLGL-TYD----GM--
MH-PP-VGLPKTGLL-------ILILAEIFINDNC------VSEE---EVWKVLSKA---
-----KIY-SGQ----MHFIYGHPKELVTKYLVME------KYLEYRQV-ANSDPARYEF
----LWGPRAHAEVR--KMEILKFLAKVRGTEPQ----S-YPSQYED---ALRDEEERAQ
VTSTLVKAAST-------------------------------------------------
------------------------------------------------------------
-----------------------S-------TAT----------------GSS--G----
------------------------------------------------------------
---------AV----------------------SD-GI----------------------
------------------SHT---------------------------------------
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------------------MSQ--LSTNLGDSSPPE-SPVPA-------------------
----------VHSRPTVLMRAP-----PASSRAPPVPWDPPPVDLQA-PMAAWQAPQPAW
EAPEGQLPAPV---AQLPQPPGLGAPMVQAPPLGGGMAKPPT------------------
---------------PGVLMVHQ-PPPGAPMAQSSTPGVLMLHPSVTGAPL---------
--APP-------------------------------------------------------
---------------------------------PPPGTPM----T-------HPPPPGTP
------------------------MGHH--PPPGNPMTHP-PPGNPMVHPLTHGAPMVHG
GPHGTP--MP-------------------HVPITGTPIAQQ---PTPGVLMAQQLTPGVL
MVQPP-------------APGAPMVQPP---PQAALM-------------------TQPA
PSITPMAKPPGPGVVMIHPPGARGPIIQTPVSG---------------APMAQTVLP---
----PGQPLATWAPQGQPLILQIQSQVI----R-------APPQV---P-----------
-------S---VPQAPQVQLATPPGWQATTPNWQVTPQGWPATPLTWQATQVTWQAPT--
----------IAWQATQPV-RQGHSTIRT-------------GHTPIRPGPAP-------
------------------------------------------------VLRQIPPMIRQI
-QP---------V-----------------------------------------------
--------MRQAPPLIRQV---PI------------------------------------
-----------------------------------------------------------R
--------------PAPHGIASQPQLWQVLPPPP-----P---------------LRQAP
QARLLLPRVPG------------TGQVSTVPPVAQ-------IHLVPQSGPQVPQT---V
L--PAQLSIP----------------------------------------IPVP------
-------QAAAQSAP-------RTVH--CPPIIWQAPKGQPPVPQEL----PV---PQEL
PVPQELPVPQEVPVPQE--------------------------------------IP---
----------VSQEIPVPQEIPVPQ------------------EIPVPQELPVPQELPVP
-QELPVPQELPVPLEFQEVQQ-AQ-AV--GWRAPKVP-----PHFWQPVSAQEAQEQ---
----ATQIAHVE-----QQQPFQGAPASSKALQTQL-PTHQAQAT--GLQAELPSVQLQP
SWQGPLPMLQAQPGASATLANFPRGSTRSRMA-PSGEPGPSSLEPRGPP-RE----RRAP
AR--DKKGPPKERM----------FIGATFCAPRG----ASASRAYVPTAWKNLPATSET
FPATSRVF-PST----SHFQPASSNAFRGPSAASE----SPKSLPFAL---QDPYACVEA
LPAVPWVPYPDGNASSACKSVPAILM-VAAAAPQ----A-SATA-AE---ASKS-SEPPR
RP-----------------------GKA--------------------------------
--TRK-----KKHLEPKE-DNCGHRLS-------------------------------SR
--D-WRGP----RTWGNPS--HSDW--EIQRAMQ-L--LGDRESLYTPQGLNDWGCPNTS
-RM---------------PRS---LEGP------------STSR-D--------------
---------QEFC---------------GDSGGSQTWMASEVP-------------S---
VSRGSSAAQEDPDRE-SQPLSPL---DERANALVQ------FLLVKD-QAKVPV--QL--
------------------------------------------------------------
----SEM---VNVVIREYKDDSLDIINRANTKLECTFGCQLKEVDTKTHTYI-IVNKMAY
PQCNLL-ASYLER-PKFS---LLM----------VVLSL----------IF--------M
-KGYC----I-R--ENLLFSFLFQLGLD--VQETSGLFRITKKLITSVFVRHR-------
---------YLEYRQIPFTEP---A--EYELLWGPRAFLETNRVHILRFLAALYEN---Q
------PQIWSCQYLDSLAELEYKDANAA--ADESHDSDDDS-------HDP--------
---TSSPHPH--------------------------------------------------
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-----------------------------------------------------MSEQSKD
LSD---------------------------------------------------------
------------------------------------------------------------
--------PNF----------------------------A---------------AEA-P
DCEM--------------------------QDS-----------------DAVPVG---I
P--PPASLAAN----------LAGPPCAPEGP------------M---------------
----AAPQAS--------------------------------------------------
------PPP--------------EERIEDVD---------PKIL-QQA-A-EE--GR---
----------------------AHQPQ--SPARP--I-PAPPAPAQLVQKAHELM-----
-------WYVLVKDQKRMVLW-FPDMV--KEVMGSYK-----KWCRSILRRTSVI-----
----LARVFGLH---------LRL-TNLHT---------MEFA-----------------
-------L----------------------------------VKALSPEELD-----RVA
----LNNRMPMTGLL-------LMILSLIYVKGRG------AREG---AVWNVLRIL---
-----GLR-PWK----KHSTFGDVRKIITEEFVQQ------NYLKYQRV-PHIEPPEYEF
----FWGSRANREIT--KMQIMEFLARVFKKDPQ----A-WPSRYRE---ALEQARALRE
ANLAA----------------------------------QAPRSSVSED-----------
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--------------------------------------MSFEQ-----------------
-----------------RSP-HCKPD-E----------------DPEA----QRE-DLG-
-------------LMGAQDPTGEE------------------------------------
-----------------------------------------------------------Q
E-A---------------------------------------------------------
------------------------------------------------------------
---TSSSDD---------E--EEE------------------------------------
---------VS--------------------------------------AAGS---SSPP
QSPQGGSS---SSTSVY-Y--TLWSQFDE----------------SSSS--QEEEGP---
------------S------TSVDLA------------HLEFMFQEVLKLKVAELV-----
-------RFLLHKYRVKEPVT-KAEML--ESVIKNYK-----HYFPVIFGKASEF-----
----MQLIFGTE---------VKE-VDPAG---------PSYI-----------------
-------L----------------------------------VTALGL-SCD----SMLG
---ND-HSMPKAALL-------IIILGVILTKDNC------APEE---VIWEALSVM---
-----GVY-VGM----EHVFYGEPRKLLTQDWVQE------NYLEYRQV-PGSDPAHYEF
----LWGSKAHAETS--YEKVVNYLGMVNAREPI----C-YPSLYEE---AFGGEQEGV-
------------------------------------------------------------
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--------------------------------------MPRGHK---SKLRAREKR-RQT
-QG-----DAHSA-----------------------------------------------
-DG-------------AQAIAAEE------------------------------------
-----------------------------------------------------------E
-GSP-------------------------SSSSP-----P---------------FEGSP
PSSP-A-------------------------TAV----------------PQGPQS---I
P--PITTGA-AG------------------------------------------------
------------------------------------------------------------
-----------------AS----STRAAGGA---------------EG-Q-DE-GGP---
-----------------------------SS-SAAPAPTERSQRDPVTRRVSMLL-----
-------QFLLYKYKMKEPIT-KAEMM--KIVNKRHK-----EHFPDILRRASVH-----
----LEVVFGLE---------LKE-VDSKG---------ESYA-----------------
-------L----------------------------------VSQLEI-SKE---ENF-I
----GSRGFPKNGLL-------MPLLGMIYRNGDR------ATEE---EMWAFLNVL---
-----GIY-IGK----WHFMFGEPRKLITKDLVQE------EYLEYRQV-PSSDPPRYEF
----LWGPRAHTEAN--KKKVLEFLAKISATDPG----A-FQAVYE--------------
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---------------------------------------MSET-----------------
---------------SE-SGA----------------------------GPTRFQGKASE
KDSG-SMMQDLL-------TVTQ--NLEVSETPKAE------------------KT----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------AEVSEAPKDP-------KASGNP---------------KAT-----------
-------------EV---------------------------SKAPEASEAA-VTQASPT
-TQQTDTQVLAS----EK--KSPAADT--KTQKADLQ-------ATTVPET---------
----QTKK-----VSC--------------------------------------------
------------------------------------------------------------
--------------------------------------------------------VT--
-------------------------------DPKV-------------------------
----N-T--KDPETEA--------AASQAGGDEP---------EP--EGAAVQVQENQDT
RPKVK--------------------A---------------------------------K
NTQKAKHLDGEEDGN---------------SDQSQASETTGGRRVSKALMASMARRASRG
PIAFWARRAS----RTRLA----A------------------------------------
------------------------------------WARRALL----SLRSPRARRGKAR
RRA---------------------------------------------------------
-AKLQS-SQEPEAPP-PRDVALL---QGRANDLVK------YLLAKD-QTKIPI--RR--
------------------------------------------------------------
----SDM---LKDIIKEYTDVYPEIIERAGYSLEKVFGIQLKEIDKSDHLYI-LLSTLEP
TDAGIL-GTTKDS-PKLG---LLM----------VLLSI----------IF--------M
-NGNR----S-S--EAVIWEVLRKLGLR--PGIHHSLFGDVKKLITDEFVKQK-------
---------YLDYAQVPNSNP---P--EYEFFWGLRSYYETSKMKVLKFACKVQKK---D
------PKEWAAQYREAMEADLKAAAEAAA--EAKAR----AEIRAQMGIGLGSE-----
----NAAGP--CNWD-------------EADIGPWA-KARIQAGAGTKAKAQAQESGGAS
----AGASTGTSVGTGAS--ASASAGA--SGGFSTSSNLTATLTFGLFAGLSGAGASTSS
SSGACG-FSYK-------------------------------------------------
------------------------------------------------------------
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---------------------------------------MAQKMDRGAGLLGYQ------
-------------------------------------------------------AEASV
EDSA-LLMQTLM-------EAIQ--IS-EAPPTNQA--TA--------------------
------------------------------------------AASMPNASPQSSQPPTA-
N------------------------------------------------EMAD-------
------IQVSAAAARPKT------------------------------------------
-----------------------------AF---------------KAQ-----------
-------------NAT----------------TKGPNGVYDFSQAHNANEMP-NNHPKAA
F-------------------KSQNATP--KGPNAAYD-------FSQAATT---------
----GELATNKSEMAFKGQNAT-TKVGPNT---------T-YNFSQPPNASEVANNRPKT
------------------------------------------------------------
----------------------------------------------AFKAWNDTTKAPTA
-------------------------------DTQN-----------QNV-----------
----NQT---KMAASP--------PDIETN--PS---------ISEPDGAAAQTSADGSQ
AQNLE--------------------S---------------------------------R
TIIRGKRTRKINNLNV---------EENSSGDQRRAPLPAGTWRSAPVPVTT-QNPPGAP
PNVLWQTPLA----WQNPS----GWQNQTARQTP----P-ARQSPPARQTPPAWQNPVAW
QNPVIWPNPVIWQNPVIWPNPI-VWPGPVVWPNPLAWQNPPGWQTPPGWQTPPGWQGPPD
WQG---PPDWPLPPDW-PLPP-DWPLP-TDWPLPPDWIPADWPIPPDWQNLRPSPNLRP-
-SPNSRASQNPGAPQ-PRDVALL---QERANKLVK------YLMLKD-YTKVPI--KR--
------------------------------------------------------------
----SEM---LRDIIREYTDVYPEIIERACFVLEKKFGIQLKEIDKEEHLYI-LISTPE-
SLAGIL-GTTKDT-PKLG---LLL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPLLGDLRKLLTYEFVKQK-------
---------YLDYRRVPNSNP---P--EYEFLWGLRSYHETSKMKVLRFIAEVQKR---D
------PRDWTAQFMEAADEALDALDAAAA--EAEAR----AEARTRMGIGDEAV-----
------SGP--WSWDDIEFELLT-WDEEGDFGDPWS-RIPF----TFWARYHQNARSRFP
QTFAG---------------------P--IIGPSGTASA------NFAANFGAIGF----
--------FWVE------------------------------------------------
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--------------------------------------MPRGHK---SKLRGSEKR-RQA
-KG-----DTHSV-----------------------------------------------
-DG-------------AQATVAQE------------------------------------
-----------------------------------------------------------E
-RSP-------------------------SS-SS-----P---------------FGGFP
PSSP-A-------------------------TAV----------------PQGPQS---I
P--PITTAA-AG------------------------------------------------
------------------------------------------------------------
-----------------AS----GTRAAGGA---------------EG-Q-DE-GGP---
-----------------------------SS-SAAPAPTERSQRDPVTRRVSTLL-----
-------QFLLYKYKMKEPIT-KAEMM--KIINKRHK-----EHFPDILRRASVH-----
----LEVVFGLD---------LKE-VDSKG---------QSYA-----------------
-------V----------------------------------VSKFEI-SKE---ENF-I
----GSRGFPKNGLL-------MPLLGMIYRNGDR------ATEE---EMWAFLNVL---
-----GIY-DGK----WHFMFGEPRKLITKDLVQE------KYLEYRQV-PNSDPPCYEF
----LWGPRAHTEAN--KKKVLEFLAKISATDPS----A-FQALYE--------------
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--------------------------------------MH--------------------
--------------YRERRQ-HCKLE-E----------------DLQA----QGE-SLG-
-------------LMSVQSLAAEE------------------------------------
-----------------------------------------------------------E
EAATFFS-----------------------------------------------------
------------------------------------------------------------
------ASPALI----SGT--VEE------------------------------------
---------VL--------------------------------------ATGS---PDHR
QNPQEICS---FLSAII-S--ILCSQTD--------------------------------
----------------------------------------ESSSKALDKKMAHLV-----
-------YFLLHKYRNKEQLT-KAEML--SAVIKNDE-----EHFPAIFSGASEC-----
----MRL--------------------------------HSHV-----------------
-------F----------------------------------VSSLDL-SYN----GVLD
-D----HSKPTAGLL-------ITVLGMIFMEGNC------VPEE---TIWEALRVL---
-----GVC-PRR----EHCLYGEPRKFLTQDWVQE------EYLEYRQV-PGGDPAHYEF
----LWGPRAYAETS--KMKVLEHVG----RDAT----S-YPSLFEK---ALRERRAR--
------------------------------------------------------------
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--------------------------------------LLLPCHWVLDATFSDGSLGQWL
K--NTCA-----------------------------------------------------
------------------------------------------------------------
--------------------TY-------ALSPVVLTPQPQPQKK---------------
--------------------------------------------------------PDKD
FSDFHLGHLREVRLFLRGGTSDQQ------------------------------------
-----------------------------------------------------------M
-DSLVL-YSTYF------------KLWRSPSGSP---DLQ---------------LS---
--D---------------------------------------------------------
--------LHF--------------GSQPEGK------------FSLRRAVSVKQR----
----EEPQDWPLN---------EK---------------------------------RTL
WKDSD-----LPTWRGGAGCTLPLPAVSPGK---------------RMWG-E--------
------------------------------KAG---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------DKDMPAAGMPPLP-------
------------------------QSPPE-IPPQG-------PP-KISPQGPPQSPPQSP
---------LNSC------------------SSPLLWTRLDEE-------------SGS-
EEEDTATWHALPESE-SLPRYAL---DEKVAELLQ------FLLLKY-QTKEPV--TK--
------------------------------------------------------------
----AEM---LMTVIKKYKDYFPMVFGKAHEFI-LIFGIALTDMGPDNKCFF---EDLDL
IYEGSL-IDDQGM-PQNC---LLI----------LILSM----------IF--------I
-KSSC----A-P--EEVIWEVL--------------SAIGPIQ-----RPARE-------
---------VLEFLSKLSSII---P--SSFPSWYMDALKDMEDRAQAIIDTTDDAT---A
------MASASPSVMSTNFC------PE--------------------------------
------------------------------------------------------------
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---------------------------------------MSQKMDCGAGLLGFQSPEA--
--CRALRRPLPQPPASTLPFSALPT-PCDPLSPQLLNPPPLLSSNLTPPRSA-PPAEASV
EDST-LLMQTLM-------EAIQ--IS-EAPPTNQA--TA--------------------
------------------------------------------AASAPNASPQSSQSPTA-
S------------------------------------------------EMAD-------
------MQALAAATKPKT------------------------------------------
-----------------------------AF---------------KAQ-----------
-------------NAT----------------TKGPNAAYDFSQALNAKETP-NTPPTAA
F-------------------KSQNAPP--KGPNAAYD-------FSQAATT---------
----SELTANKSEMAFKAQNTT-TTVGPNA---------T-YNFSQSLSASEMVSTQPKT
------------------------------------------------------------
----------------------------------------------AFRAWNDTTKAPVA
-------------------------------DTQT-----------QNV-----------
----NQA---KIATSQ--------ADIEADPCPG---------ICESDGAAAQTSADGSQ
AQNLE--------------------S---------------------------------R
TIIRGKRTRKINNLNV---------EESSSGDQRRAPLAPGTWRSAPVPVTT-QSPPGAP
PNVLWQTPLA----WQNPS----GWQNQPARQTP----P-ARQSPPARQTPPAWQNPVAW
QNPVIWPNPVIWQNPVIWPNPI-VWPGPVVWPNPLAWQNPPGWQTPPGWQTPPGWQGPPD
WQG---PPDWPLPPDW-PLPP-DWPLP-TDWPLPPDWIPTDWPVPPDWQNLRPSPNLRP-
-SPNSRASQNLGASQ-PRDVALL---QERANKLVK------YLMLKD-YTKVPI--KR--
------------------------------------------------------------
----SEM---LRDIIREYTDVYPEIIERACFVLEKKFGIQLKEIDKEEHLYI-LISTPE-
SLAGIL-GTTKDT-PKLG---LLL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPLLGDLRKLLTYEFVKQK-------
---------YLDYRRVPNSNP---P--EYEFLWGLRSYHETSKMKVLRFIAEVQKR---D
------PRDWTAQFMEAADEALDALDAAAA--EAEAR----AEARTRMGIGDEAV-----
------SGP--WSWDDIEFELLT-WDEEGDFGDPWS-RIPF----TFWARYHQNARSRFP
QTFAG---------------------P--IIGPGGTASA------NFAANFGAIGF----
--------FWVE------------------------------------------------
------------------------------------------------------------
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--------------------------------------MWLILTSA----LEAR------
--------TAAS-------------------------------------IRGVASGQP--
---RVN---SQDWSG-----------------------------------------VKAP
HLLPFC----PHS---C-L-FG-------L----TTAIMPRGHK---SKLRAREKR-RKA
-RE-----ETQGL-----------------------------------------------
-KV-------------AEATAAEK------------------------------------
-----------------------------------------------------------E
-ECP-------------------------SS-AP-----V---------------LGDTP
ASSP-A-------------------------AGI----------------PQKPQG---A
S--PATTAAAA-------------------------------------------------
------------------------------------------------------------
-----------------VS----CTESDEGA---------------KS-Q-GE-ENA---
-----------------------------SS-SQGTTSTEKSAKDPVAWEAGMLM-----
-------HFMLHKYKMREPIM-KADML--KFVDGKYK-----DHFPEILNRASHR-----
----LELVFGLD---------LKE-DNPSD---------HTYK-----------------
-------L----------------------------------VSKLNL-TND---GNL-T
----NDWDFPRNGLL-------MPLLGVIFLNGNS------ATEE---EIWKFMNML---
-----GAY-DGE----EHLIYGEPRKFITQDLVRE------KYLKYKRV-PNSDPPRYQF
----LWGPRAYTETS--KMKVLEFLAKVNGTTPR----D-FPSHYEE---ALRDEEERAR
VR-ASIRARRR-RTAT--------------------------------------------
--------------------------T-------------------------------FR
--------------------ARS--R-----------------------AAFS-NSSQPM
------------------------------------------------------------
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--------------------------------------MSQIQ-----------------
-----------------ENP-EGTAV-Q----------------G-EI----FEE-TQG-
-------------LEVAQVPKEAEESCSSPHPLVPTSR-------------KGE------
---TWKE-------------T----------------RDLKV---------AQVSE---H
VEET----------------------------GSPHTLMPS------------------S
PEGEIY---------------------------------------KETQGLEVTEVSKDV
EEPFSS-SNPLL----PSN--KKA------------------------------------
---------DP--------------------------------------IDET---PSTS
WASSA-------------E--GPSRQQAQ----------------VSP-------FN---
------------I------VQGIPF------------NLAPLPI----MKVDFMV-----
-------NYMLYKYQVRELMS-MEDMI--RTVIREDE-----SHFHEILSLANDR-----
----MEMVFGLE---------VKK-VDPIN---------HFYG-----------------
-------L----------------------------------FIKLGL-TYD----GM--
HH-HE-YSFPKTGLL-------ILILGVVFMKGNR------ATEE---EIWRVLNPM---
-----GII-AGV----PHFLFGEPRKLVTEEFVWE------QYLECQPV-PNSFPVRYEY
----VWGPRARAETS--KMKVLEYVAKIHGVHPS----I-FQAQYQE---ALLEEEERTL
AMLLDRAASSS-------------------------------------------------
------------------------------------------------------------
-----------------------M-------VAE----------------SSS--A----
------------------------------------------------------------
---------IPS---------------------RF-------------------------
------------------PPR---------------------------------------
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---------------------------------------MDRRNDYGYRMPTFQ--G---
--------PLPPP--GSLGLP----------------------------FSSDVQTETTE
KDNV-LLMRTLL-------STSK--DT-----PIASRSKK-------------SKTKKTS
IKAI----------TKT-TPT--PPPVPPANDIAGNKPKVTLQALNLPMFTQISQASST-
T------------------------------------------------EAAN-------
------IQASVTA-QTKKA-KTKRVTP------KLSLNGTEDVTTQLKSPLKALNLPVTS
PTIQS---PIANESANSLAL-IAVSKPKKAP---------------KAK-----------
-------------KAA----------------NKTIPSATEISLASTATHTA-TTQGQTA
-KETASIQATAATIRAKKTSKAKRTTA--KTTNTDTE-------YVESSNA---------
----LEGS----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------S
RQIEA--------------------S---------------------------------T
VGLRPKKPKGKKVANKGP---------N------------SASELSEAPPAIQMVTNHAL
SVTVRIRRGS----RARKA----ATKTRAQESQA----QITDQGAQAKMATPQ-ASISAL
ETQ------------VA------------AAVQALADDYLAQL----SLEPTTRTRGKRN
RKVRSKPRATPLCKGE-SRPTKSMELC-GRNSNLFHFVTPDIFFFSLMKSKHPNGEERT-
GSNYRRIPWGRRPPP-PRDVAIL---QERANKLVK------YLLVKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LKDVIQEYDEYFPEIIERASYALEKMFRVNLKEIDKQSSLYI-LISTQES
SAG-IL-GTTKDT-PKLG---LLM----------VILSV----------IF--------M
-NGNK----A-S--EAVIWEVLRKLGLR--PGVRHSLFGEVRKLITDEFVKQK-------
---------YLEYKRVPNSRP---P--EYEFFWGLRSYHETSKMKVLKFACKVQKK---D
------PKDWAAQYREAVEMDVQAAAVAVA--EAEAR----AEARAQMGIGEEAV-----
------AGP--WNWDDMDIDCLT-REELGDDAQAWN-RFSF----EIDSRAQENADSTNN
LNFNQGPSTRNSFSDGANISFGGITNP--SGGFG--------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------GINGITFGSAPNTSANFSSAASISFGDTSNSSTSFSGGASISFSGTPST
SATFCNTASISFGSASSTSTSFSSGASISFGGAPNTSTSFSS----------------TA
TISFGGAPSTNTSFSSTASISFGGAPSISSSFSGGSSISFGGSPS--TSTSFSGGASISF
GGAPCTSASF-----NGFGGTLSSTAAGFSGALSTSTNFGSAPTTSTVFSGAVSTTTGFG
GTLSTSVCFGSSPCSGAGFGGTLSTSICFGGSPSTNNGFGG----TLSTSVSFGASSSTS
SDFGGTLSTSVSFGGSSGTS-AGFGGALNSSTSFGGAISTSAGFGNALNSSASFGSAIST
GFGGALNSSASFGGAINTSTGFGGALNSSASF----------GGAISTSAGFGNALSTSA
SFGSVLNGSSGFGGAISTSASFGNALNNSAGFGGAISTSASFGGALNDSAGFGGAISTSA
SFGGALNGSSGFGGAISTSASFGGALNGSSGFGGAISTSASFGGALNGS-AGFGGAISTS
ASFGGALNGSAGFGGAISTSASFDGALSNNAGFGSAISTSASFDGALNNSAGFGSAISTS
ATFGGGLNNSAGFGGAISTSASFGGGLNNSAGFGSAISTSASFGGGLNNSAGFGGAISTS
ASFGGAISTNPDFGGAFSTSVGFGGALS-TTDFGSTHSNSISFGSAPTTSVSFGSSHSTN
LCFGGAPSNSLCFGSASNTNLCFGGSSSTNSCFSGATSANYSEG----AIFSFGNGLSTN
AGFGNGLGTSAGFGSSLGTSTGFGGSLGPSASFNGGLGTSNGFGGGLGTSTDFGGGLSPN
ADFGGGLGTSAGFDGGLNTSTDFGGGLGTNAGFGDGLGSNTGFGGGLVTNDGFAGDLSAN
NGFGSTLGTGAGFGVSLSTGDGFGNGSNASFDRGLNTIIGFGSDSNTSSSFTGEPSTGSS
FSNGPSSIVGFSGGPSTGAGFCNGPST-GSFGGGPSTGAGFGGPSTGG------------
----------------------------------GFGGPSTAAGFGGGLSGSAGFG----
-------GGLNSSAGFSGG-PSTGTGFGGGGTNLGACGFSYG

------------------------------------------------------------
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-----------------------------MTSAGVFNAGSDER-------------ANSR
DEEYPCSSEVSPSTE-SSCSNFI---NIKVGLLEQ------FLLYKF-KMKQRI--LK--
------------------------------------------------------------
----EDM---LKIVNPRYQNQFAEIHRRASEHTEVVFAVDLKEVNPTCHLYD-LVSKLKL
PNNGRI-HVGKGL-PKTG---LLM----------TFLVV----------IF--------L
-KGNC----A-N--KEDTWKFLDMMQIY--DGKKYYIYGEPRKLITQDFVRLK-------
---------YLEYHQVPCSYP---A--HYQFLWGPRAYTETSKMKVLEYLAKVNDI---A
------PGAFSSQYEEALQDEEESPSQRCS-RNW----------------HYCSGQDCLR
AKFSSFSQPY--------------------------------------------------
------------------------------------------------------------
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--------------------------------------MPNDQK---NIRSPKQ------
---------------DT---------------------------------------N---
------------------------------------------------------------
-----------------------------------------------------------N
-EAP-------------------------R------------------------------
-LTN-V-------------------------TNE----------------VVTISE---A
T--KTIYFV--S----SHIQLERNAV----NF-------------------SMPAR----
-------HHT----------------------------RITQFT-SGNIITVS-------
--------------------------FGRLA---------------NGFH-NPKMN----
----------------ETP----------RS-AQTISERSNVSADIIESKVASLV-----
-------KLMLLKYQMKEPIT-KEEMI--QTVIKNYE-----QHFNEIFFKAHKR-----
----MEMIFGLD---------VKE-INETN---------HCYV-----------------
-------F----------------------------------IISLGLTFDG-----MGC
----GKEGVPKTGIL-------ILILGIIFMKDNS------ATEE---DIWDILNQI---
-----GIY-ENE----HHFVFGDTKDLITNHFVRE------NYLVYRRR-A-NESSCFEF
----LWGKRAHAETS--KMKVLEFMAMVNETVPS----D-FGYKYEE---ALEDE-----
------------------------------------------------------------
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--------------------------------------MPRGQK---SKHCAREKR-RQA
-RA-----ETQGL-----------------------------------------------
-HD--------------QATTSRG------------------------------------
-----------------------------------------------------------E
-ETT--------------------------SSPP-----D---------------SESTP
SSSS-A-------------------------AGT----------------ATGPQG---A
Q--GTTSAAAG-------------------------------------------------
------------------------------------------------------------
----------------GAA----RSRSGVGA---------------EG-Q-VQEGE----
-----------------------------NS-SRASAAAESSHTDLLTMESENLV-----
-------QYMLFQYKMRELIK-RSEMV--QVIHKRYR-----EQFPEILSRASEQ-----
----MEMVFGMV---------LKE-VRPNS---------HCYT-----------------
-------L----------------------------------VSNLDL-SDS----ESMR
----SDWGLMKNGLL-------MPLLGVIYLNGHR------ASEE---EVWKFLNIL---
-----GIY-DGR----MHFIFGDTRKLITEDLVQE------EYLEYNQV-PGSDPPHYEF
----LWGPKALTENS--KTKVLQFLTKVNDLVPD----A-LLPHYEE---ALREEAERTG
ARAAT-GTRAGTSAS-----TC---A----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------HSRATSSRS----------------------
------------------SGP---------------------------------------
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---------------------M-------SLVSQNARR----------------------
------------------------------------------------------------
------------------CNAEIT------------------------------------
-----------------------------------------------------------A
-DY---------------------------------------------------------
-----------------------------------------------------------S
D--GRGEIQA----------------TNASGP------------P-T-------------
---------------------------------------------------PM------L
----------VVDAPQ----CPQAPINPQCV---------------NTSQ-AV-------
---------QDT----N--DLEV--LID-EQSRRLGA---LRVHDPLEDRSIALV-----
-------NFLRMKSQKEGSIQ--QSEM--LEFLREYS-----DQFPEILRRASAH-----
----LDRVFGLN---------LRV-IDPQA---------DTYN-----------------
----------------------L-------------------VSKRGS-QIT----DRIA
----ESLDMPKASLL-------ALVLGHILLNGNR------AREA---SIWDLLLKV---
-----DMW---DKPQRINNLFGNTRILLTTDFVRM------RFLEYWPV-YGTNPLEFEF
----LWGSRAHR--EVTKM-----------------------------------------
------------------------------------------------------------
--------------------------E-------------------------------AL
K-----------------------F---VS----------------DAYDEEP-------
------------------------QSWPE-EYN------------KALEADKTKER---S
---------------------------------------------------------LT-
AG---L--------E-FWSED---TMNDKANDLVQ------LAIGVS-EELLPI--HQ--
------------------------------------------------------------
----DEL---LAHTGKEFEDVFPNILNRATLILDMFYGLSLIEVDTSEHIYL-LVQQPES
EEEQVM-LESLGR-PTQE---YVM----------PILGL----------IF--------L
-MGNR----V-K--EANVWNLLRRFSVD--VGRKHAI--------TCKLMRQR-------
---------YLECRPLSYSNP---V--EYELLWGPRAHHETTKMKVLEYMARLYRK---L
------PQDWPEQYREAVE-----------DEEARAKSEATTMFF----LGP--------
---M--------------------------------------------------------
------------------------------------------------------------
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------------------------------------------

------------------------------------------------------------
------------------MSQ--LSKNLGDSSPPAEAPKPP-------------------
----------VYSRPTVLMRAP-----PASSRAPPVPWDPPPIDLQA-SLAAWQAPQPAW
EAPQGQLPAPV---VPMTQPPALGGPIVPAPPLGGPMGKPPT------------------
---------------PGVLMVHP-PPPGAPMAQPPTPGVLMVHPSAPGAPMAHPPP-PGT
PMSHPP-------------------------PPGTPMAH---------------------
-----P---------P------------------PPGTPM----V-------HPPPPGTP
------------------------MAHP--PPPGTPMVHPPPPGTPM------------P
PPPGTP--MA-------------------QPPAPGVLMAQP---LTPGVLMVQPAAPGAP
MVQPA-------------APGAPMVQPP----PAAVM-------------------TQPP
PSGAPMAKPPGPEVLMIHPPGARAPMTQPPASG---------------APMAQPAAPPAQ
PMAPPAQPMASWAPQAQPLILQIQSQVI----R-------APPQV---P-----------
-------Q---GPQAPPAQLATPPGWQATSPGWQATPQGWQVP-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------QP---V
L--PAPLSAP----------------------------------------L---------
--------SAP-----------QAVH--CPSIIWQAPKGQPPVPHE--------------
------------------------------------------------------------
------------------------------------------------------------
---------IPTSMEFQEVQQ-TQ-AL--AWQAQKAP-----THFWQPLPAQEAQRQ---
----APPMVQLE-------QPFQGAPPSQKAVQIQL-PPQQAQAS--GPQAELPTLQLQP
SWQTPPAVLQAQPGPPLAAANFPLGSAKSLMTP-SGESRASSIDRRGSS-KE----RRTS
SK--ERRAPSKDRM----------IFAATFCAPKA----VSAARAHLPATWKNLPATPET
FAPSSSVF-PAT----SQFQPASLNAFKGPSAASE----TPKSLPYAL---QDPFACVEA
LPAVPWVPQPNMNASKASQAVPTLLM-ATAAAPQ----A-TATT-QA---ASKTSVEMPR
RS-----------------------GKA--------------------------------
--TRK-----KKHLEAQE-DSRGHTLA-------------------------------FH
--D-WQGP----RPWENLN--LSDW--EVQSPVQ-V--LGDWEHPNTPRGLSGWEGPSTS
-RI---------------LSG---WEGPSTSWALSAWEGPSTSR-A--------------
---------LGLS---------------ESPGTPLPLVVSEVA-------------G---
VSPGSSATQDNSKVE-AQSLSPL---DERANALVQ------FLLVKD-QAKVPV--QR--
------------------------------------------------------------
----SEM---VKVIIREYKDECLDIINRANNKLECAFGYQLKEIDTKNHAYI-IINKLGY
QAGDLM-ASCLDR-PKFG---LLM----------VVLSL----------IF--------M
-KGNC----V-R--EDLIFHFLFKLGLD--VRETNGLFGNTKKLITEVFVRQK-------
---------YLEYRRVPYTEP---A--EYEFLWGPRAFLETSKMLVLRFLAKLHKK---D
------PRCWPFHYLEALAECEWEDTDEDE-PDG--S--DSA-------RGP--------
---TSRPPPR--------------------------------------------------
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----------------------------------MDRRNGYGYRMPAFQSKHLSGEERS-
GINYRRIPWGRRLPP-PRDVAIL---QERANKLVK------YLLVKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LKDVIQEYDEYFPEIIERASYALEKMFRVNLKEIDKQSSLYI-LISTRES
SAG-IL-GTTKDT-PKLG---LLM----------VILSV----------IF--------M
-NGNK----A-S--EAVIWEVLRKLGLH--PGVRHSLFGEVRKLITDEFVKQK-------
---------YLEYKRVPNSRP---P--EYEFFWGLRSYHETSKMKVLKFACKVQKK---D
------PKDWAAQYREAVEMEVQAAAVAVA--EAEAR----AEARAQM------------
---------G-IGEE--------------------P-RYSL----GICPHSSL-------
------------------------------------------------------------
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--------------------------------------MPLEQ-----------------
-----------------RSQ-HCKPE-E----------------GLEA----RGE-ALG-
-------------LVGAQAPATEE------------------------------------
-----------------------------------------------------------Q
E-A---------------------------------------------------------
------------------------------------------------------------
----ASSSSTLV----EVT--LGE------------------------------------
---------VP--------------------------------------AAES---PDPP
QSPQGASS---LPTTMN-Y--PLSSQSYE----------------GSSN--QEEEGP---
------------S------TFPDL---------------ESEFQAALSSKVAELV-----
-------HFLLLKYRARELVT-KAEML--GTVVGNWQ-----YFFLVIFSKASDS-----
----LQLVFGIE---------LME-VDPIS---------HVYI-----------------
-------F----------------------------------ATCLGL-SYD----GLLG
---NN-QIMPKTGFL-------IIILAIIAKEGDC------APEE---KIWEELSVL---
-----EVF-EGR----EDSIFGDTKKLLTQYFVQE------NYLEYRQV-PGSDPACYEF
----LWGPRALIETS--YVKVLHHMVKISGGPPI----S-YTLLREW---VLREGEE---
------------------------------------------------------------
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--------------------------------------MPRGQK---SKLRARERR-RQA
-RS-----GTQEP-----------------------------------------------
-KG-------------AQATAAED------------------------------------
-----------------------------------------------------------A
-ELP-------------------------STSSA-----D---------------VGVAS
PSSS-A-------------------------SGL----------------PQGLQR---A
P--PTTTTR-RG------------------------------------------------
------------------------------------------------------------
----------------HVS----RKRSGKGA---------------KR-Q-GE-ESE---
-----------------------------NP-LQASASHESASRDPLSRKAGLLM-----
-------QFMLYKYKLKEPIK-RVELL--KIISRQFR-----QHFPEILKKASER-----
----LELVFGLE---------LQE-DKPKG---------QLYT-----------------
-------L----------------------------------VPKLEV-SKD---GSQ-S
----SVWGFPRNGLL-------MPLLGVIFLNENC------ASEE---EIWEFLNVL---
-----GVY-DGK----KHLIFGEPRKLITKDLVQE------EYLEYQQV-PNSDPPRYQF
----LWGPRAHAETS--KMKVLQFLARVNNTDPT----A-FPSLYEE---AVNDEKEKAR
AR-A-AA--T--SAIT--------------------------------------------
--------------------------K-------------------------------AG
--------------------QGP--R-----------------------AKAD-SSSHP-
------------------------------------------------------------
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---------------------------------------MSDT-----------------
---------------SE-SGA----------------------------GVTRFQAEASE
KDSS-LTMQTQL-------TVTQ--NVEAPETPKAS------------------KA----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------PEVSEDVKVS-------EASGVS---------------KAT-----------
-------------EV---------------------------SKTPEAQEAP-ATQASST
-TQLTDTPVPAA----EN--KSPAADT--KKQNADPQ-------AVTMPAT---------
----ETKK-----ASC--------------------------------------------
------------------------------------------------------------
--------------------------------------------------------VA--
-------------------------------DTKV-------------------------
----N-A--KAQETEA--------AASQAPADEP---------EPEPESTAVQAPENQDT
RPKVK--------------------A---------------------------------K
KARKVKHLDGEEDGS---------------SDQSQASGTTGGRRVSKALMASMARRASRG
PIAFWARRAS----RTRLA----A------------------------------------
------------------------------------WARRALL----SLRSPKARRGKAR
RRA---------------------------------------------------------
-AKLQS-SQEPEAPP-PRDVALL---QGRANDLVK------YLLAKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LKDIIKEYTDVYPEIIERAGYSLEKVFGIQLKEIDKNDHLYI-LLSTLEP
TDAGIL-GTTKDS-PKLG---LLM----------VLLSI----------IF--------M
-NGNR----S-S--EAVIWEVLRKLGLR--PGIHHSLFGDVKKLITDEFVKQK-------
---------YLDYARVPNSNP---P--EYEFYWGLRSYYETSKMKVLKFACKVQKK---D
------PKEWAAQYREAMEADLKAAAEAAA--EAKAR----AEIRARMGIGLGAE-----
----NAAGP--CNWD-------------DADIGPWA-KARIQAGAEAKAKGQESG--SAS
TGTSTST------NNSA------SAST--SGGFSAGTSLTATLTFGLFAGLGGAGTSTSG
SSGACG-FSYK-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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--------------------------------------------------------MAE-
----------------------------------------------------------GS
YR-----M-E-------SETYNVEDMDEGSDEVG--EEEMVEGNDYE----EFGAFGGYG
TLTSFDIRI--LRAFGSLG-----------------------------PGLRILSNEPWE
LENP-MLARTLM-------EAFQ--LDPETLANEAAAHAV-------------NVARAAA
---S----------NRA-ARAA--------------------AAAARATYNQV---VTNR
-------------------------------------------------PVAT-------
------DQASGEDTQPMTYAAQ--AQ--------------------AATPEATLAAPHIS
------QMLVTSEMATPGAPAK-STQPQTGS---------------QAQ-----------
-------------EAA----------------TEGPSAACGFSQAPCASEMD-ATRPKTA
FLGQ----------------------------NDLFD-------FTQPAGV---------
----SGMAFSRSKRPAPAQEA--ATEGPSA---------AS-GVLQAAPAREGAATRPKT
T-----------------------------K-----------------------------
------------------------------------------------------------
--------------------------------------------------------SGKA
LAKTRWVEPQNAVTAA--------AAKT-KMATS---------IPEPEGAAA---PAQHS
AE-----------------------P---------------------------------W
VRMGGKRTKKSKHLDDEY--------ESSE-EEREPPAVPPTWRPSQPPMT---------
---------V----R---------------------------------------------
----------------------------------------AHMV----------------
-----------------PRPP-----------------------------M----A----
-LRSQVPSRHVLCLP-PRNVTLL---QERANKLVK------YLMIKD-YKKIPI--KR--
------------------------------------------------------------
----SDM---MKDVIREYDEHFPEIIERATYTLEKKFGIHLKEIDKEEHLYI-LVCTRDS
SAR-LL-GKTKDT-PRLS---LLL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPFLGDLRKLITEDFVKQK-------
---------YLEYKKVPNSSP---P--EYEFLWGLRARHETSKMRVLRFIAQNQNR---D
------PREWKAHFLEAVDDAFKTMDVDMA--EEHAR----AQMRAQMNIGDEAL-----
------IGR--WSWDDIQVELLT-WDEDGDFGDAWA-RIPF----AFWARYHQYILNSNR
ANRRA------TWRAGVSSGTNGGASTSILDGPSTS-ST---IRTRNAARTS--------
----ANFFSWIQ------------------------------------------------
------------------------------------------------------------
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---------------------M-------SLVSQNARR----------------------
------------------------------------------------------------
------------------CNAEIT------------------------------------
-----------------------------------------------------------A
-DY---------------------------------------------------------
-----------------------------------------------------------S
D--GRGEIQA----------------TNASGP------------P-T-------------
---------------------------------------------------PM------L
----------VVDAPQ----CPQAPINPQCV---------------NTSQ-AV-------
---------QDT----N--DLEV--LID-EQSRRLGA---LRVHDPLEDRSIALV-----
-------NFLRMKSQKEGSIQ--QSEM--LEFLREYS-----DQFPEILRRASAH-----
----LDRVFGLN---------LRV-IDPQA---------DTYN-----------------
----------------------L-------------------VSKRGS-QIT----DRIA
----ESLDMPKASLL-------ALVLGHILLNGNR------AREA---SIWDLLLKV---
-----DMW---DKPQRINNLFGNTRNLLTTDFVRM------RFLEYWPV-YGTNPLEFEF
----LWGSRAHR--EVTKM-----------------------------------------
------------------------------------------------------------
--------------------------E-------------------------------AL
K-----------------------F---VS----------------DAHDEEP-------
------------------------QSWPE-EYN------------KALEADKTKER---S
---------------------------------------------------------LT-
AG---L--------E-FWSED---TMNDKANDLVQ------LAIGVS-EELLPI--HQ--
------------------------------------------------------------
----DEL---LAHTGKEFEDVFPNILNRATLILDMFYGLSLIEVDTSEHIYL-LVQQPES
EEEQVM-LESLGR-PTQE---YVM----------PILGL----------IF--------L
-MGNR----V-K--EANVWNLLRRFSVD--VGRKHAI--------TCKLMRQR-------
---------YLECRPLSYSNP---V--EYELLWGPRAHHETTKMKVLEYMARLYRK---L
------PQDWPEQYREAVE-----------DEEARAKSEATTMFF----LGP--------
---M--------------------------------------------------------
------------------------------------------------------------
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------------------------------------------

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------------------------------------------------------------
--------------------------------------MPRGQK---SKLRAREKR-RQA
-RA-----KNAL------------------------------------------------
--E-------------GQASPSPF------------------------------------
-----------------------------------------------------------F
-GCP-------------------------H------------------------------
QTIP-V-------------------------AGM----------------PTPPNM---P
M--GA-------------------------------------------------------
------------------------------------------------------------
--------------YSTYS----DTYANTHA---------------QN-L-DE-------
-----------------------------KS-SDDSEDVEDWCKDPINHKVVLLV-----
-------QFLIEKYQKKEVIT-KADML--KSVIKTSK-----NHFNEILKRASEH-----
----MELAFGVD---------LKE-VDPNR---------HCYA-----------------
-------L----------------------------------FNKLEH-TFD----GVMG
----E-EKVPNSGLL-------MIVLGVIFMKDNC------APET---EIWNVLSMM---
-----GVY-ANR----KHFIYGDPKKVITEDMVQL------KYLEYRQV-PNSNPPSFEF
----MWGPRARAEIS--KMKILEFWAKIHDTTPD----S-FATLYKA---ALKDDEERAQ
ARAA-ARA----------------------------------------------------
-----------------------------------------------------------R
--------------------TATTA------------------------------SS---
------------------------------------------------------------
------------Y-----------------------------------------------
------------------SRAMM---HSSP--PY--------------------------
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---------------------------------------MAQKMDCGAGLLSFQA-----
--------------------------------------------------------ETSV
EDST-MLMQTLM-------EAIQ--ISSEAPPTNQA--TA--------------------
------------------------------------------AASGQNASLQSSQPPTA-
K------------------------------------------------EMAD-------
------IEVSAAAARPKT------------------------------------------
-----------------------------AF---------------KAQ-----------
-------------NTT----------------TKGPNGVYDFSQAHNAKEMP-NTQPKTT
F-------------------KCQNASP--KSPNAACD-------FSQAATT---------
----GELAAKKCEMALKARNTT-TDVGSST---------A-YSFSQFPNGSEMTNNQPKM
------------------------------------------------------------
----------------------------------------------AANAWNDTTKVPVA
-------------------------------DTQT-----------QNV-----------
----NQA---KMATSQ--------AEVETS--PV---------LSESNGAAAQTSADGSQ
AQNLE--------------------S---------------------------------R
TIIRGKRTRKINNLNV---------EDNGSGDQRRASLASGNWRSAPVPGTT-QNPPGAP
SHVLWQTPLA----WQNPS----GWQNQTARQTP----P-ARQSPPTRQTPPAWQNPVAW
QNPVIWPNPVIWQNPVIWPNPI-VWPGPIVWPNPMAWQNVPGWQSPPGWQTPPGWQGPPD
WQG---PPDWPLPPDW-PLPP-DWSLP-TDWPFPPDWIAADWPIPPDWQNLRPSPNLRP-
-SPNSRASQNPSAPQ-PRDVTLL---QERANKLVK------YLMLKD-YTKVPI--KR--
------------------------------------------------------------
----SEM---LRDIIREYTDVYPEIIERACFVLEKKFGIQLKEIDKDEHLYI-LISTPE-
SLAGIL-GTTKDT-PKLG---LLL----------VILGI----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPLLGDLRKLLTYEFVKQK-------
---------YLDYRRVPNSNP---P--EYEFLWGLRSYHETSKMKVLRFIAEVQKR---D
------PRDWTAQFMEAADEALDALDAAAA--EAEAR----AEARTRMGIGDEAV-----
------SGP--WSWDDIEFELLT-WDEEGDFGDPWS-RIPF----TFWARYHQNARSRFP
QTFTG---------------------P--IIGPGGTAGA------NFAANFGAIGF----
--------FWVE------------------------------------------------
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----------------------------------MDRRNDYGYRMPTFQSKHLNGEERT-
GNNFRRIPWGRRPPP-PRDVAIL---QERANKLVK------YLLVKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LKDVIQEYDEYFPEIIERASYALEKMFRVNLKEIDKQSSLYI-LISTQES
SAG-IL-GTTKDT-PKLG---LLM----------VILSV----------IF--------M
-NGNK----A-S--EAVIWEVLRKLGLR--PGVRHSLFGEVRKLITDEFVKQK-------
---------YLEYKRVPNSRP---P--EYEFFWGLRSYHETSKMKVLKFACKVQKK---D
------PKDWAAQYREAVEMDVQAAAVAVA--EAEAR----AEV---CYPCLQIP-----
------LAAV-LPME--------------------P-MCSF----GISVHTAA-------
------------------------------------------------------------
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--------------------------------------IMPSHMN---------------
-----------------EPW---KLE-E----------------DRQY----PIE-MPN-
-------------LVAEELFWAMQ------------------------------------
-----------------------------------------------------------E
EEEEDALSL------SS---SLSS------------------------------------
------------------------------------------------------------
------SPSVLF----IDS--LEE------------------------------------
---------VS--------------------------------------AAEA---PSPP
QSSQRACP---SPHAME-A--FPWSHSED----------------ESSSI-RDEEGP---
------------N------TEGGSE----------DDADSLLH-KALHSKIMEMV-----
-------EFLLLKYRAKEPTT-KAEIL--SSAIKDHQ-----DHFPEIFSAATEC-----
----IQLVFGIV---------VME-MDPSA---------HTYF-----------------
-------L----------------------------------VIALGL-TYD----GMVS
-N--G-HKYPNTGLL-------VTLLCVIASEGDC------DPEE---KVWEALKVL---
-----GVQ-DGK----VHWLYGEPRELITKVWVQE------QYLVYRQV-PNSYPARYEF
----LWGPRAHTETT--MLKAIKFVLMVNHRDSH----F-VPSLPEG---PECNENHY--
------------------------------------------------------------
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--------------------------------------------------------TAQ-
----------------------------------------------------------GS
YS-----M-E-------SEGYNVEDMDEGSQGVG--EEEMIEGNDYE----EFGAFGGYG
TLTSFDIHI--LRAFGSLG-----------------------------AGFRILSNEPWE
LENP-VLAQTLM-------EALQ--LDPETLASEAAARAT-------------NIARPAA
---S----------NWA-TPAI--------------------AATAHITSNNR---AAAN
H------------------------------------------------PVAR-------
------DQASGDDTEPMTYAE---AQ--------------------GVTPRTTPAFPQTS
------KMPVNSEMTAPGAPAT-STEPQTAS---------------QAQ-----------
-------------EAA----------------TEGPSTASAFSQAPRASELD-TTRPKTV
FLGQ----------------------------NDVFD-------FTQPAGV---------
----SGMAFPRPKRPTPAQEA--ATDGLSA---------AS-RVHQAASAKEVAATQPKT
T-----------------------------K-----------------------------
------------------------------------------------------------
--------------------------------------------------------SGKA
LAKTRWVEPQNVVAVT--------AAEA-KMATS---------IPEPEGAAA---TVQHS
AE-----------------------P---------------------------------R
ARMGGKRTKK-KHLDDEY--------ESSE-EEREPPAVPPTWRASQPPLT---------
---------A----R---------------------------------------------
----------------------------------------TPMA----------------
-----------------PRPP-----------------------------M----T----
-LRSQIPSRHVLCLP-PRNVVLL---QERANKLVK------YLMIKD-YKKIPI--KR--
------------------------------------------------------------
----SDM---LKDVIREYDEHFPEIIERATYTLEKKFGIHLKEIDKEEHLYI-LVCTQDS
SAR-LL-GKTKDT-PRLS---LVL----------VILGL----------KA--------S
-ISEA-----------------KTLGVS--LGVEKSPSRRLEA-----------------
KISFPLSLRYLEYKKIPNSSP---P--EYEFLWGLRARHETSKMRVLRFIAQNQNR---D
------PREWKAHFLEAVDDAFKTMDVDMA--EEHAR----AQMRAQMNIGDEAL-----
------IGR--WSWDDIQVELLT-WDEDG-FGDAWA-RIPF----AFWARYHQYLLNSNR
ANRRA------TWRAGVSSGTNGGASTSILDGPSTS-ST---IRTRNAARAG--------
----ANFFSWIQ------------------------------------------------
------------------------------------------------------------
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--------------------------------------MPHA-P----------------
-----------------KYQ-RYAPG-E----------------DIQA----QTE-VQD-
-------------LVDAQVPAAEE------------------------------------
-----------------------------------------------------------E
E-EQ-----------------------NLGTQ----------------------------
------------------------------------------------------------
------------------------------------------------------------
-DGVEVPAAVA--------------------------------------PSTH-------
QSPERSFS---VS-TSLSI-------SDE------------------------DSSN---
------------P------QEEASV------------GTESLPSNLLEEKIMDLV-----
-------QLLLRKYQMRQPIT-KAEML--NIVIKTYK-----SQFSVIFQRACKC-----
----MAMVFGID---------VKE-VDPTI---------HSYA-----------------
-------H----------------------------------VNSLDL-TYV----GMLS
---DD-QSMPKNGLL-------ILILGMIFLEGNC------TSEE---EMY----MM---
-----EVY-AGR----EHYIYEEPSQLTARDWVQE------NYLEYQQV-PSSDPAHYEF
----LWGPRAHAETS--KMKVLEFLAEV--------------------------------
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------------------------------------------------------------
------------------MSL--VSQNSRRRRRRSAK---ATA-----------------
----------Q-NSSWGEIF-------SAAMPGPDVPQGPSDLETLQ-GLCAS-------
---ED-----------------PGT------------SVPPT------------------
---------------PDEGPTT---------SEPPTVS---EGSIASEQPTV-SEG-PNT
SELPTP---------------I-EG----PSTSGPPAVS---------------------
-----EGLNTAVLINAYEGLS------PPVSPSASEGSSV---S----------------
--------------------------EQPTVTEGLNTSELPLS--------DEGPSTSVL
TTTAEGLGIS-------------------VSPTPAEGPSTS-------VL--TTVSEGLG
ISVPPTSSEGLS--------NL-----------------------------------MPP
T------LSEGPGINVPPPSGEGPSTSVPPTTS---------------EGPDTS------
------------------------------------------------------------
------------------------------------------VLPPSGEGPSISVPPPSS
KGQSTSV---------LPSSGEGPITSVP---------------PTDSEGPAA-------
-------------------------------------------------------ETPST
----------S-------------------------------------------------
---------------------GII------------------------------------
-----------------------------------------------------------S
EMAA------------------------AAECPSTSGMAA---------------AAECP
ST-SGMA-AAA------A-GPS-TSGMAA-AAD-GP--S---T-SGM---LA-ASA----
N--PAPVLSL----------------GASVGP----------------------------
------------------------TSS----------NSCVA------------------
----------------R------SSSDSKRP---------------K-------------
-------GAEGPMEFQVLRDRENSNSITIMGLGTTQVALTLKPQDPMEQNVAELL-----
-------QFLLVKDQSKYPIR-ESEMR--QYIVKEYR-----SQFPEILRRAAAH-----
----LECIFRFE---------LRE-LDPEE---------RTYI-----------------
-------L----------------------------------LNKLGPVPFE-----GLE
----ENPNGPKMGLL-------MMILGQILLNGNQ------AKEA---EIWEMLWRM---
-----GVQ-RER----RLSIFGNPKRLLSVEFVWQ------RYLDYRPI-TDRTPVEYEF
----FWGPRSHIETS--KMKILKFMAKIYNKDPS----D-WPEPYNE---ALEEEAARAY
AEG---------------------------------------------------------
------------------------------------------------------------
----WQALPPFRRPFFEE----------A-AE------------------VAS-PD----
-FD---------------------------------------------------------
---------VSAY-------------------------P---------------------
---------SKYPPH-SWPESRM---ESKSRKLVQ------LFLLMD-STKLPI--PK--
------------------------------------------------------------
----KGI---LYYIGRECSKVFPDLLNRAARTLNHVYGTELVVLDPRNHSYT-LYNRREM
EDTEEI-VDSPNR-PGNN---FLM----------QVLSF----------IF--------I
-MGNH----A-R--ESAVWAFLRGLGVQ--AGRKHVI--------TCRYLSQR-------
---------YIDSLRVPDSDP---V--QYEFVWGPRARLETSKMKALRYVARIHRK---E
------PQDWPEQYREAMEDEANRADAGHR-QF----------LVHNFR-----------
------------------------------------------------------------
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---MGT---EAQPVVKVVILHCLPSCPHSCLLPPTRVIMSQD-Q----------------
-----------------ESP-RCTHD-Q----------------HLQT----FSE-TQS-
-------------LEVAQVSKPLE------------------------------------
-----------------------------------------------------------K
T-----------------------------------------------------------
------------------------------------------------------------
---FLSSSHPLV----PGK--VKEA---P---------------------AAK-------
----------A--------------------------------------ESPL-------
EVPQSFCS---SSIAVT-T--TSSSESDE----------------ASSNQ-QEEDSP---
------------S------SSEDTS------------DPRNVPADALDQKVAFLV-----
-------NFMLHKYQMKKPIT-KADML--KIIIKDDE-----SHFSEILLRASER-----
----LEMIFGLD---------VVE-VDPTT---------HCYG-----------------
-------L----------------------------------FIKLGL-TYD----GMLS
---GE-KGVPKTGLL-------ILVLGVIFMKGNR------ATEE---EVWEVLNLT---
-----GVY-SGK----KHFIFGEPRELITKDFVKE------KYLEYQQV-ANSDPARYEF
----LWGPRAKAEAS--KMKVLEFVAKVHGSHPH----S-FPSQYAE---ALKEEEERAR
ARI---------------------------------------------------------
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--------------------------------------HASEAQ---EQSHARGKC-RQV
-RG-----DTQEA-----------------------------------------------
-QA-------------SAAEAPKE------------------------------------
-----------------------------------------------------------E
-CP--------------------------SSPSS-----A---------------PQGSL
PSSP-A-------------------------AGD----------------HQQLQG---A
M--VPSSPDA-G------------------------------------------------
------------------------------------------------------------
-----------------PS----CAASDEGA---------------QG-P-EE-ESA---
-----------------------------GA-SQEAPATQSTRKDPLARKARILV-----
-------EFLLEKYTKKEPIT-QSALM--KIISRKYR-----QHFSEILSTARER-----
----VELVFGLE---------MKE-VDRSR---------NIYT-----------------
-------L----------------------------------ISKLNL-GAN---DCP-S
----DDGGLPKSGLL-------MVLLGVIFMNGNC------ATEE---EIWEFLSML---
-----GIY-AGR----RHCIFGEPRRLITKDLVQK------EYLNYRRV-PNSDPPCYEF
----LWGPRACAETS--KMKVLEVLAKLHGRVPS----S-FPDLYDE---ALRDQAERAG
WR-GVARAPTM-AE----------------------------------------------
----------------------------------------------------------AS
--------------------APS--R-----------------------AKSC-SSSHI-
------------------------------------------------------------
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--------------------T-RAEML--SYVIREHK-----GHFREIFGKVLNC-----
----LQVALGID---------LRV-VDPIQ---------HCYV-----------------
-------L----------------------------------ETALGL-TYD----GMQD
---H-DQSMPKTSFL-------IMVLGLIFSKGNC------APEE---ELWESLSVM---
-----DVY-DGR----EHHLYGEPRKLLTEEWVRE------GYVEYRLV-PHSDPARYKF
----LWGPRAHAETT--KMRVLQHLAKFNQVDPR----S-FSSLYDE---ALRDENERAQ
------------------------------------------------------------
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------------------------------------------------------------
------------------MSL--VSQNSRRRRRRSAK-----------------------
--------------------APNAPGLPAAMPGPDVPQDPSDPQILP-GLCAS-------
---KG-----------------PGT------------SVLPT------------------
---------------PEEGPST---------SVPPTAS---EGSSSSGELTI-SEG-LNT
SELPTP---------------S-EE----PSTSGPPTVS---------------------
-----AGPCTAVSVTALEGPS------TPVLPTVSEGSKA---SE-------HPTASEG-
----------------------------------PNISELCLS--------DEGPSTSAQ
LTPGEGLSTS-------------------VPPTFSEESGISVPT---SVP--HTVSEGPG
IIVSLPSNEVPG--------I-----------------------------------SVLP
I------ASEGLGINVPPTSSEGPNTSVPLIIS---------------EEPGMA------
------------------------------------------------------------
------------------------------------------VPPPSGEELSTSMPLTTS
EESGVNT---------PPTSIEELSTSVP---------------PTACEGPTE-------
------------------------------------G------------------ESTSV
----------QPT----------------------------------------------P
GEDPSAS---------VLASAS--------------------------------------
------------------------------------------------------------
------------------------------EGLGTCGLLP---------------CGEGP
ST-STQC-PLG------E-GPS-TSQMPA-AAA-GA--S---A-CEI---PA-AAE----
N--PAALLRS----------------SASAGP----------------------------
------------------------SASECA-IAL--------------------------
-----------------------ASSASVRP---------------K-------------
-------GAEGPMEFQVLRDSENANSITIMGLGTAQVALTLKPQDPMEQNVAELL-----
-------QFLLVKDQSKYPIR-ESEMR--QYIVKEYR-----SQFPEILRRAAAH-----
----LECIFRFE---------LRE-LDPEE---------HTYI-----------------
-------L----------------------------------LNKLGPVPFE-----GLE
----DSPNGPKMGLL-------MMILGQIFLNGNQ------AREA---DIWEMLWRM---
-----GVQ-RER----RLSIFGNPKRLLSVEFVWQ------RYLDYRPI-TDCTPVEYEF
----FWGPRSHLETT--KMKILKFMAKIYNKDPM----D-WPEQYNE---ALEEDAIRAA
ADD---------------------------------------------------------
------------------------------------------------------------
----WQAVPHFRRPFFEE----------VSPE------------------L---------
--L---------------------------------------------------------
---------LPGY-------------------------P---------------------
---------SKYPPH-SWPESRL---ESKSRKLVQ------LFLLMD-STKLPI--PK--
------------------------------------------------------------
----KGI---LYYIGRECSKVFPDLLNRAARTLNHVYGTELVVLDPRNHSYT-LYNRREM
EDTEEI-VDSPNR-PGNN---FLM----------QVLSF----------IF--------I
-MGNH----A-R--ESAVWAFLRGLGVQ--NGRKHVI--------TCRYLSQR-------
---------YIDSLRVPDSDP---V--QYDFVWGPRARLETSKMKALRYVARIHRK---E
------PQDWPEQYREAMEDEANRADVGHR-QL----------LVQNLR-----------
------------------------------------------------------------
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--------------------------------------MSLEQ-----------------
-----------------RSL-HYKPE-E----------------ALEA----QQE-ALG-
-------------LVCVQA-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---AASSSSPLV----LGT--LEE------------------------------------
---------VP--------------------------------------TAGS---TDPP
QTPQGASA---FPTTIN-F--PRWRQPNE----------------SSRS--HEEEGP---
------------S------TSRVL---------------ESLFRAVLTKKVADLV-----
-------HFLLLKYRAREPVT-KAEML--ESVIKNYK-----HCFPVIFGKASES-----
----LQLIFGID---------VKE-ADSTG---------HSYV-----------------
-------L----------------------------------VTCLGL-SYD----GLLG
---DN-QIMPKTGFL-------IIILVMIAMEGGR------APEE---EIWEELNVM---
-----EVY-DGR----EHSAYGEPRKLLTQDLVQE------KYLEYRQV-PYSDPARYEF
----LWGPRALAETS--YVKVLEYVIKVSARVRF----F-FPSLREA---ALREDEE--G
V-----------------------------------------------------------
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--------------------------------------MSHA-S----------------
-----------------KRR-RCVLE-E----------------GSET----QS------
-------------------VLAVV------------------------------------
-----------------------------------------------------------E
E-DT-----------------------SSSSTCSSSFPSSS-------------------
------------------------------------------------------------
S-SSSSSFCPLI----LSS--PEE--E---------------------------------
----------L--------------------------------------NDPS---QGPS
QNPPSSFL---SPTA-V-A--SPMSQSED----------------G-SSS-QKEESL---
------------S------TSEALP------------NAESLPRNVINDKVADLV-----
-------EFLLLKYRTKELTT-KAEML--NVVIQDYQ-----DHFPEIFREASEC-----
----LQLAFGVD---------VKE-VDPSD---------DSYV-----------------
-------L----------------------------------VTTLGL-TCD----GMMS
---DG-ETMPKNGIL-------IVILSMIFMEGDC------VSEE---KVWEVLNVM---
-----GVY-DGT----DHFIYGEPRELITRVLVQE------QYFEYRQV-PNSDPARYEF
----LWGPRAHAEIC--KMTLLEFLAKISGSDPR----A-FPLWYEE---ALRQQEERAQ
SGITTTDDTSA-------------------------------------------------
------------------------------------------------------------
-----------------------MA--------S----------------ESS----SA-
------------------------------------------------------------
----------PS---------------------SSFC-----------------------
------------------PE----------------------------------------
------------------------------------------------------------
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--------------------------------------MPRGHK---SKLRAREKR-RQA
-HG-----EDPDL-----------------------------------------------
-RG-------------SQTSAVEE------------------------------------
-----------------------------------------------------------E
-EFP--------------------------PSLS-----P---------------CGSAS
QSAS-A-------------------------AGL----------------PQESQR---A
R--FT-SPPASA------------------------------------------------
------------------------------------------------------------
-----------------SS----CADSDEGA---------------KS-Q-DA-ES L---
-----------------------------SS-FHTGASSEGSDHDPLYRKTGK LV-----
-------RFLLDKYKTKESIT-EAEML--KIVNRKYK-----RHFSEILKRASES-----
----LELVFGLD---------LKQ-VDPSN---------HTYA-----------------
-------L----------------------------------VPKLAP-SDE---GNL-S
----HGRGLPKNGIL-------MPLLAMIFMNGNR------VSEE---KMWEFLEDM---
-----GLH-DGR----KHFLYGEPRKLVTIDLVQA------KYLEYQQV-PNSDPPCYEF
----LWGPRAHAETS--KMKVLEFLAKINNTVPS----T-FQSRYEE---ALRDEEERSR
VR-AATRAGAT-AVAR--A-----------------------------------------
--------------------------S---------------------------------
--------------------RCS--Q-----------------------P----------
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--------------------------------------MPHG-Q----------------
-----------------KTW-LWKCE-Q----------------CLQA----QRE-TQG-
-------------WRSPSPP----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------PSYALM----PGI--PEMM---P---------------------ATG-------
----------I--------------------------------------LSNP-------
QDPWGPCS---T--A-LAA--APWSPSDQ----------------D-SSR-QGEEGP---
------------G------MSQFQP------------DAESLFRDETDDKVADLV-----
-------KFLLLKYRMKEPFT-GAEIT-------THR-----DHFSVIFGEASEC-----
----LQLVFGIN---------VKK-VDPTS---------QWYV-----------------
-------L----------------------------------VSILGL-TYD----WILS
---DG-HSMPKTSL--------VMVLGVILLKGNC------LLEE---EIWKLLSVM---
-----GVY-PRR----EHFILGEPRKLLTRDCVWE------KYLKYRQV-PDSEPICYEF
----LWGPRVHGETS--KMKVLEVLAKVYGTVPS----A-FPTQYEE---ALRDEEE---
------------------------------------------------------------
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---------------------------------------MSDT-----------------
---------------SE-SGA----------------------------GLTRFQAEASE
KDSS-SMMQTLL-------AVTQ--NVEVPETPKAS------------------KA----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------LEVSEDVKVS-------KASGVS---------------KAT-----------
-------------EV---------------------------SKTPEAQEAP-ATQASST
-TQLTDTQVLAA----EN--KSLAADT--KKQNADPQ-------AVTMPAT---------
----ETKK-----VSH--------------------------------------------
------------------------------------------------------------
--------------------------------------------------------VA--
-------------------------------DTKV-------------------------
----N-T--KAQETEA--------SPSQAPADEP---------EP--ESAAAQSQENQDT
RPKVK--------------------A---------------------------------K
KARKVKHLDGEEDGS---------------SDQSQASGTTGGRRVSKALMASMARRASRG
PIAFWARRAS----RTRLA----A------------------------------------
------------------------------------WARRALL----SLRSPKARRGKAR
RRA---------------------------------------------------------
-AKLQS-SQEPEAPP-PRDVALL---QGRANDLVK------YLLAKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LKDIIKEYTDVYPEIIERAGYSLEKVFGIQLKEIDKNDHLYI-LLSTLEP
TDAGIL-GTTKDS-PKLG---LLM----------VLLSI----------IF--------M
-NGNR----S-S--EAVIWEVLRKLGLR--PGIHHSLFGDVKKLITDEFVKQK-------
---------YLDYARVPNSNP---P--EYEFFWGLRSYYETSKMKVLKFACKVQKK---D
------PKEWAAQYREAMEADLKAAAEAAA--EAKAR----AEIRARMGIGLGSE-----
----NAAGP--CNWD-------------EADIGPWA-KARIQAGAEAKAKAQESG--SAS
TGASTST------NNSA--S--ASAST--SGGFSAGASLTATLTFGLFAGLGGAGASTSG
SSGACG-FSYK-------------------------------------------------
------------------------------------------------------------
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--------------------------------------------------------MAE-
----------------------------------------------------------GS
FS-----V-Q-------SESYSVEDMDEGSDEVR--EEEMVEGNDYE----EFGAFGGYG
TLTSFDIHI--LRAFGSLG-----------------------------PGLRILSNEPWE
LENP-VLAQTLV-------EALQ--LDPDTLANETAARAA-------------NVARAAA
---S----------NRA-ARAA--------------------AAAARTAFTQV---VASH
R-------------------------------------------------VAT-------
------PQVSGEDTQPTTYAA--EAQ--------------------GPTPEPPLASPQTS
------QMLVTSEMAAPGAPVT-STKSQTGS---------------PAQ-----------
-------------EAA----------------TEGPSSACAFSQAPCAREVD-TTRPSTA
FLGQ----------------------------NDVFD-------FTQPAGV---------
----SGMAFPRPKRPAPAQEA--ATEGSSA---------AS-GVPQTGPGREVAATRPKT
T-----------------------------K-----------------------------
------------------------------------------------------------
--------------------------------------------------------SGKA
LAKTRWVEPQNVVAAA--------AAKA-KMATS---------IPEPEGAAA--ATAQHS
AE-----------------------P---------------------------------W
ARMGGKRTKKSKHLDDEY--------ESSE-EEREPPAVPPTWRASQPSLT---------
---------V----R---------------------------------------------
----------------------------------------AQLA----------------
-----------------PRRP-----------------------------V----A----
-PRSQIPSRHVLCLP-PRNVTLL---QERANKLVK------YLMIKD-YKKIPI--KR--
------------------------------------------------------------
----ADM---LKDVIREYDEHFPEIIERATYTLEKKFGIHLKEIDKEEHLYI-LVCTRDS
SAR-LL-GKTKDT-PRLS---LLL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPFLGDLRKLITDDFVKQKNLELREG
TPLSVAPSWYLEYKKIPNSNP---P--EYEFLWGLRARHETSKMRVLRFIAQNQNR---D
------PREWKAHFLEAVDDAFKTMDVDMA--EEHAR----AQMRAQMNIGDEAL-----
------IGR--WSWDDIQVELLT-WDEDGDFGDAWA-RIPF----AFWARYHQYILNSNR
ANRRA------TWRAGVSSGTNGGASTSVLDGPSTS-ST---IRTRNAARAG--------
----ASFFSWIQHR----------------------------------------------
------------------------------------------------------------
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--------------------------------------------------------MAE-
----------------------------------------------------------GS
FS-----V-Q-------SESYSVEDMDEGSDEVR--EEEMVEGNDYE----EFGAFGGYG
TLTSFDIHI--LRAFGSLG-----------------------------PGLRILSNEPWE
LENP-VLAQTLV-------EALQ--LDPDTLANETAARAA-------------NVARAAA
---S----------NRA-ARAA--------------------AAAARTAFTQV---VASH
R-------------------------------------------------VAT-------
------PQVSGEDTQPTTYAA--EAQ--------------------GPTPEPPLASPQTS
------QMLVTSEMAAPGAPVT-STKSQTGS---------------PAQ-----------
-------------EAA----------------TEGPSSACAFSQAPCAREVD-TTRPSTA
FLGQ----------------------------NDVFD-------FTQPAGV---------
----SGMAFPRPKRPAPAQEA--ATEGSSA---------AS-GVPQTGPGREVAATRPKT
T-----------------------------K-----------------------------
------------------------------------------------------------
--------------------------------------------------------SGKA
LAKTRWVEPQNVVAAA--------AAKA-KMATS---------IPEPEGAAA--ATAQHS
AE-----------------------P---------------------------------W
ARMGGKRTKKSKHLDDEY--------ESSE-EEREPPAVPPTWRASQPSLT---------
---------V----R---------------------------------------------
----------------------------------------AQLA----------------
-----------------PRRP-----------------------------V----A----
-PRSQIPSRHVLCLP-PRNVTLL---QERANKLVK------YLMIKD-YKKIPI--KR--
------------------------------------------------------------
----ADM---LKDVIREYDEHFPEIIERATYTLEKKFGIHLKEIDKEEHLYI-LVCTRDS
SAR-LL-GKTKDT-PRLS---LLL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPFLGDLRKLITDDFVKQK-------
---------YLEYKKIPNSNP---P--EYEFLWGLRARHETSKMRVLRFIAQNQNR---D
------PREWKAHFLEAVDDAFKTMDVDMA--EEHAR----AQMRAQMNIGDEAL-----
------IGR--WSWDDIQVELLT-WDEDGDFGDAWA-RIPF----AFWARYHQYILNSNR
ANRRA------TWRAGVSSGTNGGASTSVLDGPSTS-ST---IRTRNAARAG--------
----ASFFSWIQHR----------------------------------------------
------------------------------------------------------------
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-----------------------------------------------------MSEQSKD
VCD---------------------------------------------------------
------------------------------------------------------------
--------PNF----------------------------A---------------AEA-S
NSEV--------------------------HSS-----------------PGITGG---P
S--PPGSQAAT----------LTEPESPPLSP------------P---------------
----DAPLVS--------------------------------------------------
------LPP--------------QAPGEEGD---------PKAL-QQA-A-DE--GR---
----------------------PHQAP----STTQLS-PAPPAPAQLVQKAHELM-----
-------WYVLVKDQKRMIIW-FPDMV--KDVIGSYK-----KWCRSILRRTSLI-----
----LARVFGLH---------LRL-TSLHT---------MEFS-----------------
-------L----------------------------------VKALEPEELD-----RVA
----LSNRMPMTGLL-------LMILSLIYVKGRG------ARES---AVWNVLRIL---
-----GLR-PWK----KHSTFGDVRKLITEEFVQQ------NYLKYQRV-PHVEPPEYEF
----FWGSRASREIT--KMQIMEFLARVFKKNPQ----A-WPSRYRE---ALEEARALRE
AHPTA----------------------------------HCPRNSVSED-----------
------------------------------------------------------------
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--------------------------------------MPRGQK---SKLRAREKR-HQA
-RC-----ENQDL-----------------------------------------------
-GA-------------TQATVAE-------------------------------------
------------------------------------------------------------
GESP-------------------------SSAYL-----L---------------FGDRP
QSLP-A------------------------AETPS-------I-------PEALQG---A
P--STTNAIA-P------------------------------------------------
------------------------------------------------------------
-----------------VS----CS-SNEGA---------------SS-Q-DE-KSL---
------------------------------G-S--SREAEGWKEDPLNKKVVSLV-----
-------HFLLQKYETKEPIT-KGDMI--KFVIRKDK-----CHFNEILKRASEH-----
----MELALGVD---------LKE-VDPIR---------HYYA-----------------
-------F----------------------------------FSKLDL-TYD----ETTS
----DEEKIPKTGLL-------MIALGVIFLNGTR------APEE---AVWEIMNMM---
-----GVY-ADR----KHFLYGDPRQVMTKDLVQL------KYLVYQQV-PNSDPPRYEF
----LWGPRAHAETS--KMKVLEFVAKMHDTVPS----A-FPSCYEE---ALRDEEQRTQ
AR-AAARAHTA-AM----------------------------------------------
----------------------------------------------------------AN
--------------------ACS--R-----------------------TTSS-SFSHAK
------------------------------------------------------------
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-------------------------------------------------------AEASV
EESA-LLMQTLM-------EAIQ--IS-ETPPPNQA--TA--------------------
------------------------------------------AASGQNASLQSSQPPTV-
S------------------------------------------------EMAD-------
------IQLSAAAARPKP------------------------------------------
-----------------------------TF---------------KVP-----------
-------------NAN----------------TKGPNGAYDFSQAINAKEMS-NTLPQAA
Y-------------------MSPNAPP--KGPNAAYN-------FSQAAIT---------
----TELTANSAEMTFKAHNATNTQVGPNA---------T-YNFSKPLNASEIANSQPKT
------------------------------------------------------------
----------------------------------------------TFKAWNNTTKVPVV
-------------------------------STQI-----------QNV-----------
----NQA---KMTSSQ--------ADIQAD--SG---------ITESNGAAAQTPADGSQ
AQNLE--------------------S---------------------------------R
TIIRGKRTRKINNLNV---------EDNINGDQRRAPLSAGPWRSAPVPVTN-LNPPGAP
PNVLWQTPLA----WQNPS----GWQNQTARQTP----P-ARQSPPARQTPPAWQNPVAW
QNPVIWQNPVIWQNPVIWPNHI-VWPGPVVWPNPLGWQNPPGWQASPGWQTPPGWQSPPD
WQA---PPEWSLPPDW-PQPP-DWPLP--EWSLPPDWITTDWPIPPEWQNLRPSPNLRP-
-TPNPRASQNLGVSQ-PRDVVLL---QERANKLVK------YLMLKD-YTKVPI--KR--
------------------------------------------------------------
----SEM---LRDIIREYTDVYPEIIERACFVLEKKFGIQLKEIDKEEHLYI-LISTPE-
SLAGIL-GTTKDT-PKLG---LLL----------VILGI----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPLLGDLRKLLTYEFVKQK-------
---------YLDYRRVPNSNP---P--EYEFLWGLRSYHETSKMKVLRFIAEVQKR---D
------PRDWTAQFMEAADEALDALDAAAA--EAEAR----AEARTRMGIGDEAV-----
------SGP--WSWDDIEFELLT-WDEDGDFGDPWS-RIPF----TFWARYHQNARSRFP
QTFAG---------------------P--IIGPGGTASA------NFAANFGAIGF----
--------FWVE------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
--------------------------------------MPRGQK---SKLRAREKR-HQA
-RC-----ENQDL-----------------------------------------------
-GA-------------TQATVAE-------------------------------------
------------------------------------------------------------
GESP-------------------------SPAYL-----L---------------FGDRP
QNLP-A------------------------AETPS-------I-------PEALQG---A
P--STTNAIA-P------------------------------------------------
------------------------------------------------------------
-----------------VS----CS-SNEGA---------------SS-Q-DE-KSL---
------------------------------G-S--SREAEGWKEDPLNKKVVSLV-----
-------HFLLQKYETKEPIT-KGDMI--KFVIRKDK-----CHFNEILKRASEH-----
----MELALGVD---------LKE-VDPIR---------HYYA-----------------
-------F----------------------------------FSKLDL-TYD----ETTS
----DEEKIPKTGLL-------MIALGVIFLNGNR------APEE---AVWEIMNMM---
-----GVY-ADR----KHFLYGDPRKVMTKDLVQL------KYLEYQQV-PNSDPPRYEF
----LWGPRAHAETS--KMKVLEFVAKIHDTVPS----A-FPSCYEE---ALRDEEQRTQ
AR-AAARAHTA-AM----------------------------------------------
----------------------------------------------------------AN
--------------------ARS--R-----------------------TTSS-SFSHAK
------------------------------------------------------------
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---------------------------------------MDRRNDYGYRLPPFQ--G---
--------PLPPP--GSLGLP----------------------------FPPDTQTETTE
EDSV-LLMHTLL-------AATK--DPLAMDPPVVNRPKK-------------SKTKKAP
IKAI----------TKA-TPA--APPVPTASEIATNKPEITLQALNLPVITQISQASST-
T------------------------------------------------EVAN-------
------TQASSVTSQPKKANKMRRVTAKSAQG-SQSPAGYEGVTTQLKSPLQVLNLPAIS
QNSHV---PIANESASSQAL-ITSVKPKKAF---------------KAK-----------
-------------KVA----------------NKAIASATEVSPAPNATHTA-ITQGQIT
-SETASIHTTAASIRTKKASKAKKTTA--KVINIDTG-------HVEARNV---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------TEAAT
RQIEA--------------------S---------------------------------V
VALRPKKSKGKKAASRGP---------N------------SLSEISEAPLATHMVTNQAL
AATLRVKRGS----RARKA----ATKSRATESQT----PVADQGSQAKMATAQ-TNVSAL
QTQ------------VA------------AAVQALADDYLAQL----SLEPTTRTRGKRN
RK-----------------------------------------------SKHLNGDERS-
GSNYRRIPRGWRPAP-PRDVAIL---QERANKLVK------YLLVKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LRDVIQEYDEYFPEIIERASYALEKMFRVNLKEIDKQCSLYI-LISTQES
SAG-IL-GTTKDT-PKLG---LLM----------VILSV----------IF--------M
-NGNK----A-S--EAVIWEVLCKLGLR--PGVRHSLFGEVRKLITDEFVKQK-------
---------YLEYKRVPNSRP---P--EYEFFWGLRSYHETSKMKVLKFACKVQKK---D
------PKDWAVQYREAVEMEVQAAAVAVA--EAEAR----AEARAQMGIGEEAV-----
------AGP--WNWDDMDIDCLT-REELGDDAQAWS-RFSF----EIEARAQENADASTN
VNFSRGASTRAGFSDGASISFNGASSS--SGGFSG-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------GPGITFGGAPSTSASFSSTASISFGGTLSTSS----------------
--------------------SFS------------------S----------------AA
SISFGGAPSTSTSFSSEASISFGGMPCTSANFSGGVSSSFSGPLS--TSTTFSGGANSGF
GG------------------IL-STTAGFSGVLSTSTSFGSAPTTSTVFSSALSTGTGFG
GTLSTSVCFGGSPSSSGSFGGTLSTSICFDGSPCTSTGFGG----TLSTSVSFGGSSSTS
ANFGGTVSTSICFDGSPSTS-AGFGGALNTS-----------------------------
-------------------------------------------------ADFGGAMSTCA
DFGGTLSTSVCFGGSPCTSVSFGGALNTNAGFGSAVSTSTDFGG----------------
------------------------------------------------------------
-----ILSTSVC------------------------------------------------
----------------------FGGSTSTSAGFGDALNTNASFGCAVSTGAGF-------
---SGAPSTNPGFGGAFSTSAGFSGALSTTTDFGGTPSNSIGFGAAPSTSVSFGGAHSTS
LCFGGAPSTSLCFGSASNTNLCFDGPPSTSACFSGATSPSFGDGPSTSTGFSFGNGLTTS
AGFGGGLST-----GGLGTSAGFSGG------------------------------LSSS
SGLDGGLGTSAGFGGGPGTSTGFGGGLGTSAGFSGGLGTSAGFGGGLVTSGAFGGGLGTN
ASFGSTLGTSAGFSGGLSTSDGFGSRPNASFDRGLSTIIGFGSGSNTSTGFTGEPSTSTG
FNSGPSSIVGFSGGPSTGVGFCSGPST-SGFSGGPSTGAGFG------------------
------------------------------------------------------------
-------GGPNTGAGFGGG-PSTSVGFSSGAASLGACGFSYG

------------------------------------------------------------
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------------------------------MPR---------------------------
----------------------RHKN----------------------------------
--K--------------------KRH-HARSEPQS---HGNAQATAEAGEEST-PSFST-
-QH-------------------EGI-SQG-LPMAESRNTSQDPQ-G------------AQ
---------TTTT-----------------ASVAVSCPGSDEA---------FSSQ----
EDDEAVSSEIPLFTE-VSDVDDF---QTRIVSLEQ------FILNRY-KLKKPI--LK--
------------------------------------------------------------
----ADM---LRIVGEDYQDRFAEMLTKVSEQIETFFALDMNEVDSIRHSYA-LVSKLKL
PNNGRV-RPGKGF-PKSG---LLM----------HILGM----------IF--------M
-NGNC----V-S--EEEIWRDLRLMHVY--PRRKHFIFGEPRKLLT-DFVRLK-------
---------YLECRQVPHSDP---P--RSEFLWGPKAHLETSKMEVLEFCAKVNGT---H
------PSAFPYCYQEALQDEKDRAEARDA-ARAATTAQV-TALS----RAMAS-TTFLP
VEKSKAFRPSDQNIEHLNRD----------------------------------------
------------------------------------------------------------
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--------------------------------------MPRGQK---SKLRAREKR-RQA
-RE-----ESGHL-----------------------------------------------
-VD-------------AQATVPEK------------------------------------
-----------------------------------------------------------E
-KPS-------------------------SSPPP-----H---------------FKDAP
QSSP-A------------------------TGAHS-------N-------PQITGR---V
H--STSTTAE-A------------------------------------------------
------------------------------------------------------------
-----------------AP----NTRFNEGA---------------KK-Q-VE-EKP---
-----------------------------NA-SQAKDTTEHWPRGPIDKKVAMLV-----
-------YYLLYKYQMKESIT-KADML--KNVIQIYK-----NHFHEILWKASEH-----
----LELVFGLD---------VKE-VDPNR---------NIYV-----------------
-------L----------------------------------VNKLES-SYN----GRVN
----ENGGVPKTGLL-------MTVLGVIFTKGNC------ATEE---QVWEVLNMM---
-----GLY-DGM----KNFIYGEPRKLITKDWVKE------EYLEYRQV-ADSDPPRYEF
----LWGPRAHAETS--KMRVLEFVAKIHNTVPS----A-FPTWYEE---ALRDEEERAR
AR-VVAKACTA-AM----------------------------------------------
----------------------------------------------------------AS
--------------------ARS--R-----------------------AMAS-SFSCPK
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------

------------------------------------------------------------
------------------MSL--VSQNSRRRRRRGAK---ATA-----------------
----------H-NS---EIQVPNAPGLPGDVPGSDVPQGPIDSQILQ-GLCAS-------
---EG-----------------PNT------------SVLPT------------------
---------------SAEGPST---------FVPPTIS---EASSASGQPTV-CEG-PGT
SVLLTL---------------S-EG----LSTSGPPTMS---------------------
-----KGLCTSVTLAALEGQN------TSRPPTSSEEPST---SL-------PPTVSERP
-S----------------------TSVPPTPGEGTSTSVLPTA--------FEGPSTSVV
STLAEGPSTS-------------------VPPTPGEEASTS-------VP--LTVPEGLS
TSVPPTPDEGPS--------TSATSVL-----PTATEG------------LSTSVISVPP
I------PGEGLSTSVPPTPSEGLSTSVPPTAS---------------EGPSSS------
------------------------------------------------------------
------------------------------------------VLPTPGEGKSTSVPPT--
----------------------GPSTSVL---------------PTASDGQS--------
---------------------------------------------------------TSF
----------VPT----------------------------------------------P
SKGSSTS---------VPPITT--------------------------------------
-----------------------------------------------------------E
GLST--------------------------SVQP-----T---------------PGEGP
ST-SVPP-TPG------E-GLS-TSVSPT-ATE-GL--S---T-TVP---PT-PGE----
G--LSILVQP----------------TASNGP--------------GSSVLPTP------
---YESPSALFSSSA-----SMNRNPSKCS-VVLPSPGESKA------------------
----------------S------VDSDSEGP---------------K-------------
-------GAEGPIEFQVLRDCESPNSITIMGLSTSRVAITLKPQDPMEQNVAELL-----
-------QFLLVKDQSKYPIR-ESEMR--EYIVKEYR-----NQFPEILRRAAAH-----
----LECIFRFE---------LRE-LDPEA---------HTYI-----------------
-------L----------------------------------LNKLGPVPFE-----GLE
----ESPNGPKMGLL-------MMILGQIFLNGNQ------AKEA---EIWEMLWRM---
-----GVQ-RER----RLSIFGNPKRLLSVEFVWQ------RYLDYRPV-TDCKPVEYEF
----FWGPRSHIETT--KMKILKFMAKIYNKDPM----D-WPEQYNE---ALEEDAARAF
AEG---------------------------------------------------------
------------------------------------------------------------
----WQALPHFRRPFFEE----------VAGE------------------VAS-PD----
-SE---------------------------------------------------------
---------VSNY-------------------------S---------------------
---------SKYPPH-SWPESRL---ESKARKLVQ------LFLLMD-STKLPI--PK--
------------------------------------------------------------
----KGI---LYYIGRECSKVFPDLLNRAARTLNHVYGTELVVLDPRNHSYT-LYNRREM
EETEEI-VDSPNR-PGNN---FLM----------QVLSF----------IF--------I
-MGNH----A-R--ESAVWAFLRGLGVQ--SGRKHVI--------TCRYLSQR-------
---------YIDSLRVPDSDP---V--QYEFVWGPRARLETSKMKALRYVARIHRK---E
------PQDWPQQYREAMEDEANRADVGHR-QF----------FVHNFR-----------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
---------------------------------------MSET-----------------
---------------SE-SGA----------------------------GPTRFQGKASE
KDSG-SMMQDLL-------PATQ--NLEVSETPKAE------------------KA----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------PEVSEAAKVP-------KASGNP---------------KAT-----------
-------------EV---------------------------SKAPEDSEAA-ATQPSTT
-TQLTDTQVLAA----EN--KSPAADT--KTQKADLQ-------AMTMPAT---------
----QTKK-----VSC--------------------------------------------
------------------------------------------------------------
--------------------------------------------------------VT--
-------------------------------DPKV-------------------------
----S-T--KAPETEA--------ADSQAGADEP---------EP--EGAAVQVQENQDT
RPKVK--------------------A---------------------------------K
NTQKVKHLDGEEDGNSG---------------QSQASETTGGRRVSKALMASMARRASRG
PIAFWARRAS----RTRLA----A------------------------------------
------------------------------------WARRALL----SLRSPRARRGKAR
RRA---------------------------------------------------------
-AKLQSASQEPEAPP-PRDVALL---QGRANELVK------YLLAKD-QTKIPI--RR--
------------------------------------------------------------
----SDM---LKDIIKEYTDVYPEIIERAGYSLEKVFGIQLKEIDKSDHLYI-LLSTLEP
TDAGIL-GTTKDS-PKLG---LLM----------VLLSI----------IF--------M
-NGNR----S-S--EAVIWEVLRKLGLR--PGIHHSLFGDVKKLITDEFVKQK-------
---------YLDYARVPNSNP---P--EYEFFWGLRSYYETSKMKVLKFACKVQKK---D
------PKEWAAQYREAMEADLKAAAEAAA--EAKAR----AEIRAQMGIGLGSE-----
----NAAGP--CNWD-------------EADIGPWA-KARIQAGAETKAKA--QESGGAS
AGASTG----TSVGTGASASASASAGA--SGGFSTSSNLTATLTFGLFAGLSGAGASSSS
SSGACG-FSYK-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------

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------------------------------------------------------------
--------------------------------------MSCS-K----------------
-----------------KSH-SHTLE-A----------------GLND----QRE-AQG-
-------------PGDAQVPATEK------------------------------------
-----------------------------------------------------------E
T-----------------------------------------------------------
------------------------------------------------------------
---ASSSLSPSI----QGT--PEVV---P---------------------AAG-------
----------K--------------------------------------PNVH-------
QSPQEALS---SSTTIK-A--TPWSKPQE----------------G-SSG-P-KQGP---
------------SA------SQAPP------------DAESLLSDVLNQKMVELV-----
-------QFLSTKYVTKEPIT-KAEML--KSVIKEHK-----GHFPVIFGKACEC-----
----MEIVFGIE---------VKE-ADPIN---------HSYV-----------------
-------L----------------------------------VKTLDL-TYD----GMLS
---D-DHGMPKTGLL-------ILILGVIFVEGNR------APEK---KIWEVLSKI---
-----GVC-AGK----KDFIYGEPRKLITNDFVQE------KYLEYRQV-PSSDPPCYEF
----LWGPRAHAETS--KMKVLQFFAKVSGTDPS----S-FSSWYEE---ALRDERERAQ
AKVAATDATRA-------------------------------------------------
------------------------------------------------------------
-----------------------TA--------S----------------ESS----SV-
------------------------------------------------------------
---------PSS---------------------SVSC-----------------------
------------------PE----------------------------------------
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------------------MSQ--LSTNLGDSSPPE-SPVPA-------------------
----------VHSRPTVLMRAP-----PASSRAPPVPWDPPPVDLQA-PLAAWQAPQPAW
EAPEGQLPAPV---AQLAQPPGLGAPMVQAPPLGGGMAKPPT------------------
---------------PGVLMVHQ-PPPGAPMAQSSTPGVLMLHPSVTGGPL---------
--AHPP-------------------------PPGTPMTH---------------------
-----P-PGTSMAHPPPPP-----------PPPPPPGTPM----T-------HPPPPGTP
------------------------MGHH--PPPGNPMTHP-PPGNPMVHPLPHGTPMVHG
GPHGTP--MP-------------------HVPITATPIAQQ---STPGVLMAQQLTPGVL
MVQPP-------------APGAPMVQPP---PQAALM-------------------TQPA
PSITPMAKPPGPGVVMIHPPGARGPIIQTPVSG---------------APMAQTVLP---
----PGQPLATWAPQGQPLILQIQSQVI----R-------APPQV---P-----------
-------S---VPQVPQVQLATPPGWQATTPNWQVTPQGWPTTPLTWQATQVTWQAPT--
----------IAWQATQPV-RQGHSTIRT-------------GHTPIRPGPAP-------
------------------------------------------------LLRQIPPMIRQI
-QP---------V-----------------------------------------------
--------MRQAPPLIRQV---PI------------------------------------
-----------------------------------------------------------R
--------------PAPHGIASQPQLWQVLPPPP-----P---------------LRQAP
QARLLLPRVPG------------TGQVSTVPPVAQ-------IHLVPQSGPQVPQT---V
L--PAQLSIP----------------------------------------IPVP------
-------QAAAQSVP-------RAVH--CPSIIWQAPKGQPPVPQEL----PV---PQEL
PVPQEIPVPQELPVPQE--------------------------------------IP---
----------VPQEIPVPQEIPVPQE------LPIPQELPVPQELPVPQELPVPQELPVP
-QELPVPQELPVPLEFQEVQQ-AQ-AV--GWRAPKVP-----THFWQPVPAQEAQEQ---
----ATQIAHVE-----QQQPFQGAPASPKALQTQL-PTHQAQAT--GLQAELPSVQLQP
SWQGPLPMLQAQPGASATLANFPRGSTRSRMA-PSGEPGPSSLEPRGPP-RE----RRAP
AR--DKKGPPKERM----------FIGATFCAPRG----ASASRAYVPTAWKNLPATSET
FPATSRVF-PST----SHFQPASSNAFRGPSATSE----SPKSLPFAL---QDPYACVEA
LPAVPWVPYPDGNASSACKSVPAILM-VAAAAPQ----A-SATA-AE---ASKS-SEPPR
RP-----------------------GKA--------------------------------
--TRK-----KKHLEPKE-DNCGHRMP-------------------------------SH
--D-WRGP----RTWGNPS--HSDW--EIQRAMQ-L--LGDRESLYTPQGLNDWGCPNTS
-RM---------------PRS---LEGP------------STSR-D--------------
---------QGFC---------------GASGGSQTWMASEVP-------------S---
VSRGSSAAQEDPDRE-SQPLSPL---DERANALVQ------FLLVKD-QAKVPV--QL--
------------------------------------------------------------
----SEM---VNVVIREYKDDSLDIINRANTKLECTFGCQLKEVDTKTHTYI-IVNKMAY
PQCNLL-ASYLER-PKFS---LLM----------VVLSL----------IF--------M
-KGYC----I-R--ENLLFSFLFQLGLD--VQETSGLFRITKKLITSVFVRHR-------
---------YLEYRQIPFTEP---A--EYELLWGPRAFLETNRVHILRFLAALYEN---Q
------PQIWSCQYLDSLAELEYKDANAAA-ADESHDSDDDS-------HDP--------
---TSSPHPH--------------------------------------------------
------------------------------------------------------------
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-----------------------------------------------------MSEQSKD
LSD---------------------------------------------------------
------------------------------------------------------------
--------PNF----------------------------A---------------AEA-P
DCEM--------------------------QDS-----------------DAVPVG---I
P--PPASLAAN----------LAGPPCAPEGP------------M---------------
----AAPQAS--------------------------------------------------
------PPP--------------EERIEDVD---------PKIL-QQA-A-EE--GR---
----------------------AHQPQ--SPARP--I-PAPPAPAQLVQKAHELM-----
-------WYVLVKDQKRMVLW-FPDMV--KEVMGSYK-----KWCRSILRRTSVI-----
----LARVFGLH---------LRL-TNLHT---------MEFA-----------------
-------L----------------------------------VKALSPEELD-----RVA
----LNNRMPMTGLL-------LMILSLIYVKGRG------AREG---AVWNVLRIL---
-----GLR-PWK----KHSTFGDVRKIITEEFVQQ------NYLKYQRV-PHIEPPEYEF
----FWGSRANREIT--KMQIMEFLARVFKKDPQ----A-WPSRYRE---ALEQARALRE
ANLAA----------------------------------QAPRSSVSED-----------
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-------------------------------------------------------SP---
---------------------GW-----------------SPWPCPVETRVAILV-----
-------KFLLLEYQTKEPIT-GAEML--KNGS-LDR-----QGQPLVSGEASEG-----
----LQLVSGID---------VEK-VDPAG---------QCYV-----------------
-------L----------------------------------VSTLGL-TYD----GTLS
---DG-HSMPKSGLL-------VTVLGVIFLQGNP------VPEK---EIWEVLSVM---
-----GMY-PGR----EHFSYGEPWKLLTRDWVRE------KYLLYRQV-PGN----KEF
----LWGPRAHAKTS--KMEVLELLAKINNTVPS----A-FPC-YED---ALRDEEARAQ
TRITTTVIEGL-------------------------------------------------
------------------------------------------------------------
-----------------------LA--------S----------------ESSL---LM-
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---------TLI---------------------TH-------------------------
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------------------MSQ--LSTNTGDSSPPE-SPMPA-------------------
----------VHSRPTVLMRAP-----PASSRAPPVPWDPPPVDLQA-PLTAWQAPQPSW
EAPEGQLPAPV---PQLAQPPALGAPMVQAPQLGGAMAKPPT------------------
---------------PGVLMVHP-PPPGAPVAQPSTPGVMMLHPSVPGAPLAHPPP-QGT
PMTHPP-------------------------PPGTPMAH---------------------
-----PLPGTPMAHPPPPPPP--------P---PPP----------------PPPPPGTP
------------------------MAHPPPPPPGTPMAHPLPPVNPMVHPLSPGTPMVHP
PQPGTSLPLP-------------------HAPIPGAPMAQQ---PTPGVLMAQQLTPGVL
MVQPP-------------AQGAPMIQHP---PAALMS-------------------Q-HP
ASITPMGKHPGPGVMMIHPPGARAPIIQPPVSG---------------APMAQPVLP---
----PAQPLVSWSPQGQPLILQIQSQVI----R-------TPQQV---P-----------
-------T---VPSTPQVQLATTPGWQVTTPNWQVTPQGWQGTPLNWQAAQLAWQAPT--
----------IAWQPP-PM-RQGHSSLRS-------------GHTPIRPGPPP-------
------------------------------------------------ILRQIQPVIRQT
-PA---------L-----------------------------------------------
--------LRHIPPLIRQTPA-AL------------------------------------
-----------------------------------------------------------R
--------------QASHA-ISQHPLWQVLPSQP-----S---------------LRQAQ
QARLLIPRTPG------------THHLPAAPQITQ-------IHLVPQAGP---------
------LSIP----------------------------------------IPLP------
-------QAAPQSAP-------RAVH--CPSIIWHAPKSQPQVPEEL----PG---PEEL
PVPEELPVPEELPVPQEVP----VPEEVPVP---------------EEVP-VPEEVP---
----------VPEEVPVPEEVPVPEE------VPVPEEVPVPEEVPVPEEVPVPEEVLSP
-EEAPAPEEAPAPEEAPAPEE-AP-----------GP-----QQLQV--------AR---
----GARQ-------------------------AHR-ATQQAQPT--GLQAELPSWQGPP
QV------LQAQPGASRAPTNFPRGPTRSHMTPPSGEPGPSSLEPRGPP-RD----RRTS
GR--GRKGPPKERM----------IIGATFSAPRG----ASASRAYLPAAWANVSGPSET
LTATSGVF-PST----SHFQPASSNAFRGPSATSE----SPKSLPLPL---QDPYACVEA
LPAVPWVPYADANASSACNAVPTILM-VTATAPQ----A-SAPG-AE---ASKT-AEPPR
RS-----------------------GKA--------------------------------
--TRK-----KKHLEPKE-EDCGHSMA-------------------------------SR
DCD-WRGP----RPCENPR--QSDW--EVQRAMQ-L--LGDQESLYTPQGRNDWACPNNS
-RV---------------PRG---FDGP------------STSQ-D--------------
---------QRFC---------------GASGGSQSWMVSELP-------------S---
ISWGPSAALEDPNGE-SQPLSPL---DERANALVQ------FLLVKD-QAKVPV--QL--
------------------------------------------------------------
----SEM---VNAVIREYRDESLDIISRANAKLERDFGCQLKEIDTRTHTYV-IVQKTDP
PEYNEL-TTHLDR-PKFN---LLM----------VVLSL----------IF--------M
-KGYS----I-R--ENLLFSFLYQLGLD--VHETSSLFRNTKKLITRVFVRHR-------
---------YLEYRQIPFTEP---A--EYELLWGPRAFLETNRMHILRFLSELYDN---Q
------AQTWTCQYLESLSELEYRDIN-----EETTDSDDDS-------YGP--------
---TSNPHPH--------------------------------------------------
------------------------------------------------------------
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--------------------------------------MPRGQK---SKRRAREKR-RQA
-RM-----ETKDL-----------------------------------------------
-GD-------------AQAAA---------------------------------------
------------------------------------------------------------
------------------------------SPAS-----T---------------SGSCP
PGPP-T-------------------------ADA----------------GQKPQG---A
E--ATTSPVA--------------------------------------------------
------------------------------------------------------------
----------------EAS----PPRSKARG---------------RR-Q-VKEHKN---
------------------------------S-SQASTSAKTAPPDPLTKKAAVLI-----
-------HFLLEKFKMKEPIR-RIDML--KLFHKRYK-----TRFPEILRRAAEC-----
----MELAFGLE---------LKE-VKPNG---------YSYT-----------------
-------L----------------------------------VSKIGL-VSD----EVLS
----SSCELPKNGLL-------MPLLSVIYLNGNR------ASEA---DVWEFLNVL---
-----GIY-DGK----QHVIFGDPRKLITEEWVQQ------NYLVYRQI-PDSDPLSYEF
----LWGSRAYTETS--KMKVLEFLAKINSTIPS----A-FPFHYAE---ALREEEKRSR
GRSL-VRS----------------------------------------------------
-----------------------------------------------------------R
--------------------AVARA------------------------------TA---
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------------C-----------------------------------------------
------------------SKFPP---R-DPSSAQ--------------------------
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--------------------------------------MPQDQ-----------------
-----------------KSE-HCKLE-Q----------------GLQA----QRE-THG-
-------------QEGAQVPGGEE------------------------------------
-----------------------------------------------------------E
EAMKAL------------------------------------------------------
------------------------------------------------------------
----------------SLI--TEE------------------------------------
---------GS--------------------------------------AAGA---QSAP
QSPQGACL---SPTAIS-A--TPATIKL------------------------EEGAV---
------------S------QLEERAI-----ALRALQDTEPWRRNRLGQKVIHLV-----
-------KFLLLKNRRKEPTM-KAEIL--ALVIRNYN-----SHFPVIFRRALEV-----
----MQLIFGID---------MKP-AGPTG---------HSYV-----------------
-------L----------------------------------VPTLGL-TYD----GMPP
-G-GV-PSAPKSSLL-------ILVLGVMFLEGNC------AREE---KIWETLGMI---
-----GVY-AEQ----EHFIYSEPRRLLTQDWVQE------KYLVYQRG-SSSLPGCSEL
----LWGLRAHAETS--KMKVLGFLAKASGTGPS----S-FPSHYAE---ALREEEERGR
APVAVRARTRA-------------------------------------------------
------------------------------------------------------------
-----------------------VG------CIH----------------SRA-------
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---------TSS---------------------TFSC-----------------------
------------------PL----------------------------------------
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--------------------------------------MPRGQK---SKLRAREKR-RQA
-RE-----ELEDL-----------------------------------------------
-ID-------------ALAFLEEE------------------------------------
-----------------------------------------------------------E
-ESP-------------------------PSASA-----C---------------LKDVS
QS-S-L------------------------DGASN-------N-------PHGLGE---A
Q--STSTSAT-A------------------------------------------------
------------------------------------------------------------
-----------------AS----HTRHPEGV---------------ND-Q-ME-ERP---
-----------------------------RC-TEDLEATDSFPRGPVDEKVIILV-----
-------HYLLYKYQMKEPIT-KADML--RNVTQMSK-----SQFPVILSRASEH-----
----LELIFGLD---------LKQ-VEPNK---------HIYV-----------------
-------L----------------------------------VNKLDL-GCD----AKLS
----DETGVPKTGLL-------MTVLGIIFTNGNC------VAEE---EVWKVFNTM---
-----GLY-DGI----EHFMFGEPRKLLTKDLVKE------NYLEYQQV-PNSDPPRYQF
----LWGPRAHAETS--KMKVLEFLAKVNNTAPS----E-FSDWYTE---ALQDEEERAR
AR-VAAKARIS-AT----------------------------------------------
----------------------------------------------------------AG
--------------------ARS--K-----------------------VKSS-KSSQLQ
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---------------------------------------MSDT-----------------
---------------SE-SGA----------------------------GLTRFQAEASE
KDSS-SMMQTLL-------AVTQ--NVEVPETPKAS------------------KA----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------LEVSEDVKVS-------KASGVS---------------KAT-----------
-------------EV---------------------------SKTPEAQEAP-ATQASST
-TQLTDTQVLAA----EN--KSLAADT--KKQNADPQ-------AVTMPAT---------
----ETKK-----VSH--------------------------------------------
------------------------------------------------------------
--------------------------------------------------------VA--
-------------------------------DTKV-------------------------
----N-T--KAQETEA--------SPSQAPADEP---------EP--ESAAAQSQENQDT
RPKVK--------------------A---------------------------------K
KARKVKHLDGEEDGS---------------SDQSQASGTTGGRRVSKALMASMARRASRG
PIAFWARRAS----RTRLA----A------------------------------------
------------------------------------WARRALL----SLRSPKARRGKAR
RRA---------------------------------------------------------
-AKLQS-SQEPEAPP-PRDVALL---QGRANDLVK------YLLAKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LKDIIKEYTDVYPEIIERAGYSLEKVFGIQLKEIDKNDHLYI-LLSTLEP
TDAGIL-GTTKDS-PKLG---LLM----------VLLSI----------IF--------M
-NGNR----S-S--EAVIWEVLRKLGLR--PGIHHSLFGDVKKLITDEFVKQK-------
---------YLDYARVPNSNP---P--EYEFFWGLRSYYETSKMKVLKFACKVQKK---D
------PKEWAAQYREAMEADLKAAAEAAA--EAKAR----AEIRARMGIGLGSE-----
----NAAGP--CNWD-------------EADIGPWA-KARIQAGAEAKAKAQESG--SAS
TGASTST------NNSA--S--ASAST--SGGFSAGASLTATLTFGLFAGLGGAGASTSG
SSGACG-FSYK-------------------------------------------------
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--------------------------------------MSRSR-----------------
-----------------KRR-CTVLE-D----------------DPET----QSD-IQQ-
-------------LIE--------------------------------------------
---------------------------------------------------SRV--PVDV
EEDSSSSST-----------------------CSSSFPL---------------------
---STC---------------------------------------S----------SSLT
PSTSFSH-SPVV----SSS----SED----------------------------------
---------FA--------------------------------------VAGS---PVLP
ESTQGACS---SFSTLA-S--TPWSSPDE----------------GSFSQ-SRED-P---
------------S------TSQLLP------------SAEGLSSFEKDAMVTNLV-----
-------NFLLFKYYMKELVS-KAEIL--NII--KSC-----NCYSQVFSEASEC-----
----MQLIFGID---------LRD-VDNLG---------HTYD-----------------
-------L----------------------------------VTCLGI-SYD----GM--
SS-KV-QGFPKTGLL-------ILILSIIFLQDDS------VPEE---DIWQTLNVM---
-----GIW-AGM----EHFIYGEPRRLILEDFVQE------QYLVYWQV-PNSEPARYEF
----VWGPRAHAETS--KMKVLKFLASISKADPR----S-FGERYEE---ALRDEDQRAL
STFMATTLADA-------------------------------------------------
------------------------------------------------------------
-----------------------SS------SAS----------------GGF-------
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--------------------------------------------------------MAE-
----------------------------------------------------------GS
FS-----V-Q-------SENYSVEDMDEGSDEVR--EEEMVEGNDYE----EFGAFGGYG
TLTSFDIHI--LRAFGSLG-----------------------------PGLRILSNEPWE
LENP-VLAQTLV-------EALQ--LDPDTLANETAARAA-------------NVARAAA
---S----------NRA-ARAA--------------------AAAARTAFTQV---VASH
R-------------------------------------------------VAT-------
------PQVSGEDTQPTTYAA--EAQ--------------------GPTPEPPLASPQTS
------QMLVTSEMAAPGAPVT-STQSQTGS---------------PAQ-----------
-------------EAA----------------TEGPSRACAFSQAPCAREVD-TTRPSTA
FLGQ----------------------------NDVFD-------FTQPAGV---------
----SGMAFPRPKRPAPAQEA--ATEGPSA---------AS-GVPQTGPGREVAATRPKT
T-----------------------------K-----------------------------
------------------------------------------------------------
--------------------------------------------------------SGKA
LAKTRWVEPQNVVAAA--------AAKA-KMATS---------IPEPEGAAA--ATAQHS
AE-----------------------P---------------------------------W
ARMGGKRTKKSKHLDDEY--------ESSE-EEREPPAVPPTWRASQPSLT---------
---------V----R---------------------------------------------
----------------------------------------AQLA----------------
-----------------PRRP-----------------------------V----A----
-PRSQIPSRHVLCLP-PRNVTLL---QERANKLVK------YLMIKD-YKKIPI--KR--
------------------------------------------------------------
----ADM---LKDVIREYDEHFPEIIERATYTLEKKFGIHLKEIDKEEHLYI-LVCTRDS
SAR-LL-GKTKDT-PRLS---LLL----------VILGI----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPFLGDLRKLITDDFVKQKNLELREG
TPLSMAPSWYLEYKKIPNSNP---P--EYEFLWGLRARHETSKMRVLRFIAQNQNR---D
------PREWKAHFLEAVDDAFKTMDVDMA--EEHAR----AQMRAQMNIGDEAL-----
------IGR--WSWDDIQVELLT-WDEDGDFGDAWA-RIPF----AFWARYHQYILNSNR
ANRRA------TWRAGVSSGTNGGASTSVLDGPSTS-ST---IRTRNAARAG--------
----ASFFSWIQHR----------------------------------------------
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--------------------------------------MPRGQK---SKLRAREKR-RKA
-RD-----ETQRL-----------------------------------------------
-NV-------------PQVTEAEE------------------------------------
-----------------------------------------------------------E
-EAP-------------------------CCSSS-----V---------------SGGAA
SSSP-A-------------------------AGI----------------PQKPQR---A
P---TTAAAAAA------------------------------------------------
------------------------------------------------------------
----------------GVS----STKSKKGA---------------KSHQ-GE-KNA---
-----------------------------SS-SQASTSTKSPSEDPLTRKSGSLV-----
-------QFLLYKYKIKESVT-KGEML--KIVGKRFR-----EHFPEILKKASEG-----
----LSVAFGLE---------LNK-VNPNG---------HTYT-----------------
-------F----------------------------------IDKVNL-TDE---ESL-L
----SSWDFPRRKLL-------MPLLSVIFLNGNS------ATEE---EIWEFLNML---
-----GVY-DGE----EHSIFGEPRKLITKDLVRE------KYLEYKQV-PSSDPPRFEF
----LWGPRAYAETS--KMKVLEFLAKVNGTTPC----A-FPTRYEE---ALKDEEKAGV
------------------------------------------------------------
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---------------------------------------MSDT-----------------
---------------SE-SGA----------------------------GLTRFQAEASE
KDSS-SMMQTLL-------TVTQ--NVEVPETPKAS------------------KA----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------LEVSEDVKVS-------KASGVS---------------KAT-----------
-------------EV---------------------------SKTPEAQEAP-ATQASST
-TQLTDTQVLAA----EN--KSLAADT--KKQNADPQ-------AVTMPAT---------
----ETKK-----VSH--------------------------------------------
------------------------------------------------------------
--------------------------------------------------------VA--
-------------------------------DTKV-------------------------
----N-T--KAQETEA--------APSQAPADEP---------EP--ESAAAQSQENQDT
RPKVK--------------------A---------------------------------K
KARKVKHLDGEEDGS---------------SDQSQASGTTGGRRVSKALMASMARRASRG
PIAFWARRAS----RTRLA----A------------------------------------
------------------------------------WARRALL----SLRSPKARRGKAR
RRA---------------------------------------------------------
-AKLQS-SQEPEAPP-PRDVALL---QGRANDLVK------YLLAKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LKDIIKEYTDVYPEIIERAGYSLEKVFGIQLKEIDKNDHLYI-LLSTLEP
TDAGIL-GTTKDS-PKLG---LLM----------VLLSI----------IF--------M
-NGNR----S-S--EAVIWEVLRKLGLR--PGIHHSLFGDVKKLITDEFVKQK-------
---------YLDYARVPNSNP---P--EYEFFWGLRSYYETSKMKVLKFACKVQKK---D
------PKEWAAQYREAMEADLKAAAEAAA--EAKAR----AEIRARMGIGLGSE-----
----NAAGP--CNWD-------------EADIGPWA-KARIQAGAEAKAKAQESG--SAS
TGASTST------NNSA--S--ASAST--SGGFSAGASLTATLTFGLFAGLGGAGASTSG
SSGACG-FSYK-------------------------------------------------
------------------------------------------------------------
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---------------------------------------MAQKMDCGAGLLGFQSPDA--
--CRAVCHPLPQPPASTLPLSAFPT-QCDPPYSQLRDPPPVLSCCCMPLRASLAPAEASV
EDSA-LLMQTLM-------EAIQ--IS-EAPPTNQA--TA--------------------
------------------------------------------A-----ASPQSSQPPTA-
N------------------------------------------------EMAD-------
------IQVSAAAARPKS------------------------------------------
-----------------------------AF---------------KVQ-----------
-------------NAT----------------TKGPNGVYDFSQAHNAKDVP-NTQPKAA
F-------------------KSQNATP--KGPNAAYD-------FSQAATT---------
----GELAANKSEMAFKAQNAT-TKVGPNA---------T-YNFSQSLNANDLANSRPKT
------------------------------------------------------------
----------------------------------------------PFKAWNDTTKSPTA
-------------------------------DTQT-----------QNI-----------
----NQA---KMATSQ--------ADIETD--PG---------ISEPDGATAQTSADGSQ
AQNLE--------------------S---------------------------------R
TIIRGKRTRKINNLNV---------EENSSGDQRRAPLAAGTWRSAPVPVTT-QNPPGAP
PNVLWQTPLA----WQNPS----GWQNQTARQTP----P-ARQSPPARQTPPAWQNPVAW
QNPVIWPNPVIWQNPVIWPNPI-VWPGPVVWPNPLAWQNPPGWQTPPGWQTPPGWQGPPD
WQG---PPEWPLPPDW-PLPP-DWPLP-TDWPLPPDWIPADWPIPPDWQNLRPSPNLRP-
-SPNSRASQNPGAAQ-PRDVALL---QERANKLVK------YLMLKD-YTKVPI--KR--
------------------------------------------------------------
----SEM---LRDIIREYTDVYPEIIERACFVLEKKFGIQLKEIDKEEHLYI-LISTPE-
SLAGIL-GTTKDT-PKLG---LLL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPLLGDLRKLLTYEFVKQK-------
---------YLDYRRVPNSNP---P--EYEFLWGLRSYHETSKMKVLRFIAEVQKR---D
------PRDWTAQFMEAADEALDALDAAAA--EAEAR----AEARTRMGIGDEAV-----
------SGP--WSWDDIEFELLT-WDEEGDFGDPWS-RIPF----TFWARYHQNARSRFP
QTFAG---------------------P--IIGPGGTASA------NFAANFGAIGF----
--------FWVE------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------MSL--VSQNSRRRRRRVAK---ATA-----------------
----------H-NSSWDEMQAPNAPGFPADMPGSDVPQGPSDSQILQ-GLCAS-------
---EG-----------------PST------------SVLPT------------------
---------------SAEGPST---------FVPPTIS---EASSASGQPTV-SEG-PGT
SLLATP---------------S-EG----LSTSGPPTIS---------------------
-----KGLCTSVTLAASEGRN------TSRPPTSSEEPST---S----------------
--------------------------V-----------------------------TSVV
PTPDEGPSTS-------------------V------------------------------
--------------------TS---VP-----PTATEG------------LST---PVPP
T------PDEGPSTSMPATPGEGRSTSMLSAAS---------------DVQSIS------
------------------------------------------------------------
------------------------------------------LVPTPGKGSSTSGPPTAT
EGLSTSV---------QPTAGEGPST----------------------------------
----------------------------------------------------------SV
----------PPT----------------------------------------------P
GEGLSTS---------VPPTAT--------------------------------------
-----------------------------------------------------------E
GLST--------------------------SVPP-----T---------------PGEGP
ST-SVLP-TPG------E-GRS-TSVPPT-ASD-GS--D---T-SVP---PT-PGE----
G--PSTLVQP----------------TASDRP--------------GSSVLPNP------
---DEGPSTLFSSSA-----SVDRNPSKCS-IVLPSPRVTKA------------------
----------------S------VDSDSEGP---------------K-------------
-------GAEGPIEFEVLRDCESPNSITIMGLSTSRVAITLKPQDPMEQNVAELL-----
-------QFLLVKDQSKYPIR-ESEMR--EYIVKEYR-----NQFPEILRRAAAH-----
----LECIFRFE---------LRE-LDPEA---------RTYI-----------------
-------L----------------------------------LNKLGPVPFE-----GLE
----ESPNGPKMGLL-------MMILGQIFLNGNQ------AKEA---EIWEMLWRM---
-----GVQ-RER----RLSIFGNPKRLLSVEFVWQ------RYLDYRPV-TDCKPVEYEF
----FWGPRSHLETT--KMKILKFMAKIYNKDPM----D-WPEQYNE---ALEEDAARAF
AEG---------------------------------------------------------
------------------------------------------------------------
----WQALPHFRRPFFEE----------AAAE------------------VAS-PD----
-SE---------------------------------------------------------
---------VSSY-------------------------S---------------------
---------SKYAPH-SWPESRL---ESKARKLVQ------LFLLMD-STKLPI--PK--
------------------------------------------------------------
----KGI---LYYIGRECSKVFPDLLNRAARTLNHVYGTELVVLDPRNHSYT-LYNRREM
EETEEI-VDSPNR-PGNN---FLM----------QVLSF----------IF--------I
-MGNH----A-R--ESAVWAFLRGLGVQ--SGRKHVI--------TCRYLSQR-------
---------YIDSLRVPDSDP---V--QYEFVWGPRARLETSKMKALRYVARIHRK---E
------PQDWPQQYREAMEDEANRADVGHR-QF----------FVHNFR-----------
------------------------------------------------------------
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--------------------------------------MPRGQK---SKLRARERR-RQA
-RS-----GTQEP-----------------------------------------------
-KG-------------AQATAAEE------------------------------------
-----------------------------------------------------------A
-ESS-------------------------SSSSS-----V---------------VGGTP
PSSP-A-------------------------SGF----------------PQESQR---A
P--PATVAG-A-------------------------------------------------
------------------------------------------------------------
----------------GVS----FKRSDKGA---------------KS-Q-GE-ERE---
-----------------------------NP-LRASASSEGSGKDPINRKAGILM-----
-------QFLLEKYRKKEPIM-KAEML--KVVNRRYQ-----EHFPEILRKASER-----
----LELVFGLD---------LKE-VNPSN---------NSYA-----------------
-------I----------------------------------VSKLEL-NDD---GSQ-S
----TCWGFPRNGLL-------MPLLAVIFLNNNC------APEE---KIWEFLNIL---
-----GVY-DGR----KHLIFGEPRKLITQNLVQE------EYLEYQQV-PNSDPPCYQF
----LWGPRAYIETS--KMKVLEFLAKVNDTVPT----A-FPLHYEE---ALRDEVRGQA
RA-A-AR--S--GNMA--------------------------------------------
--------------------------T-------------------------------AS
--------------------GSS--R-----------------------ATPS-SSGRHL
------------------------------------------------------------
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------------------------------------------

------------------------------------------------------------
------------------MSL--VSQNSRRRRGGRAN---GR------------------
--------------------KNSGKGRPAAVPGPAVPRDRSDPQILQ-GLGAT-------
---EG-----------------PGT------------SVLPT------------------
---------------PRGGSST---------SVPPTAS---EGSSAPGQLIT-SEG-RNT
SQLPTS---------------R-KG----RGTRRPPAVS---------------------
-----AGLNAAASITASEGAS------TPVLPTAPKGSKA---SE-------HLTISEGA
SI----------------------SE-QPQSHEGP--NVQPTL--------GEGSGTSVP
PTFSEESGIS-------------------EPLPSGEGLSIS-------VS--PTISEGAG
INEPSPASKAPS--------TS---VP-----PTASNG------------LG---INLPP
T------SSEGLSISVLFSASEESDISVPPPSA---------------EGLSTS------
------------------------------------------------------------
------------------------------------------MPPPSGEVQSTWVPPIIL
EGCSVKV---------RSTSRKGRRTPVR---------------SAACESPSP-------
------------------------------------S---------------AECLSTSL
----------SSI----------------------------------------------S
AEGFCSS---------LA------------------------------------------
------------------------------------------------------------
---P------------------------CAEGSDTCELLP---------------CGEGP
STSGLH---DL------EEESS-ISQMPLAAEGPSA--S---G---S---SI--------
---------------------------EDENP----------------------------
------EE-ALSCGA-----SVGMNLCKCTSLALQK------------------------
-----------------------ADDPSVRP---------------K-------------
-------RAEGFLDFQVLRDSENSNSITIMGLGTAHVALTLKPQDPMEQNVAELL-----
-------QFLLLKDQTKYPIK-ESEMR--EFIVQEYR-----NQFPEILRRAAAH-----
----LECIFRFE---------LKE-LDPEE---------HTYI-----------------
-------L----------------------------------LNKLGPVPFE-----GLE
----DIPNGPKMGLL-------MMILGQIFLNGNQ------AREA---DIWEMLWRF---
-----GVQ-RER----RLSVFGNPKRLLSVEFVWQ------RYLDYRPI-TDCVPVEYEF
----YWGPRSHVETT--KMKILKFMARIYNKDPM----D-WPAQYNE---ALEEEAERDV
PNN---------------------------------------------------------
------------------------------------------------------------
----WRAVPHFRRPLFQE----------VSPE------------------LLA-SD----
-SD---------------------------------------------------------
---------APGC-------------------------P---------------------
---------SKYSPH-SWPESRL---ESKSRKLVQ------LFLLMD-STKLPI--PK--
------------------------------------------------------------
----KGI---LYYIGRECSKVFPDLLNRAARTLNHVYGTELVVLDPRNHSYT-LYNRREM
EDMEEI-MDSPNR-PGNN---FLM----------QVLSF----------IF--------I
-MGNH----A-R--ESAVWAFLRGLGVQ--NGRKHVI--------TCRYLSQR-------
---------YIDSLRVPDSDP---V--QYDFVWGPRARLETSKMKALRYVARIHRK---E
------PQDWPDQYREALEDEANRAEAGRR-PL----------VVRNLR-----------
------------------------------------------------------------
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---------------------M-------SLVSKNACH----------------------
------------------------------------------------------------
------------------RSAETT------------------------------------
-----------------------------------------------------------A
-DY---------------------------------------------------------
-----------------------------------------------------------S
D--FHGEMQA----------------TDASGL------------P-V-------------
---------------------------------------------------SM------I
----------VPDAPQ----GPQAPVDPQVA---------------SASQ-AA-------
---------QDP----K--DLDV--LID-EQSRRLGA---LRVHDPLEDRSIALV-----
-------NFMRMKSQIEGSIQ--QTEM--LEFLREYS-----DQFPEILRRASAH-----
----LDRVFGLN---------LRV-LDPQA---------DTYN-----------------
----------------------L-------------------ISKRGL-QTN----DWIA
----ESLDMPKAGLL-------ALVLGHILLNGNR------ARET---SIWDLLLKV---
-----DVL---GEPQRINIPFGNTRNLLTTDFVRM------RFLEYWPV-YGTNPLEFEF
----LWGSRAHK--EITKM-----------------------------------------
------------------------------------------------------------
--------------------------E-------------------------------AL
K-----------------------F---VA----------------EAHDEEP-------
------------------------WSWPE-EYN------------KALEADKAKER---S
---------------------------------------------------------QA-
AG---L--------E-FWSED---TMNDKANDLVQ------LAINVT-EELLPI--HQ--
------------------------------------------------------------
----DEL---LAHTGKEFEDVFPNILSRATLILDLFYGFSLIEVDTSEHIYL-LVQQPES
EEEQMM-LESLGR-PTQE---YVM----------PILGL----------IF--------L
-MGNR----V-K--EANVWNLLRRFGVD--VGRKHAI--------TCKLMRQR-------
---------YLECRPLSYSNP---V--EYELLWGPRAHLETTKMKALEYMARLYRK---Q
------PQDWPEQYREAVE-----------DEEARARSEATAMFF----FGP--------
---M--------------------------------------------------------
------------------------------------------------------------
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--------------------------------------MPHGQK---SKHCAHEKR-QQD
-RA-----ETQGL-----------------------------------------------
-HD--------------HATTFGE------------------------------------
-----------------------------------------------------------E
-ETT-------------------------SFSPP-----D---------------SESTP
SSSS-A-------------------------AGT----------------LKGRQG---A
Q--GTTSAAAGAICKRSGVGGT--------------------------------------
------------------------------------------------------------
--------ADSRS--------------GVGA---------------KG-Q-VQEGE----
-----------------------------NS-SQASAAAERCHTDL-TRDSESLL-----
-------WYMLFKYMMRELIK-RSEML--KVIHRSYR-----EEFPEIFRRDSEC-----
----MELEFSLV---------LKE-VRPNS---------HCYT-----------------
-------L----------------------------------VSNLDL-SDS----ESMR
----GNWGLPKNGLL-------MPLLGVTYLNGHR------ASEE---DIWKFLNML---
-----NIY-DGR----RHFIFGDTEKLITQDLVQE------VYLEYRQV-PSSDPPRYEF
----LWGPKALTQNS--KTKVLQILTRVNDSAPD----T-LQPRYED---SWREEVESSG
ARAAA-GTGPSASAST--G------PSAL-------------------------------
------------------------------------------------------------
------------------------------PVLAF-----LPQ-----------------
------------------------------------------------------------
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--------------------------------------MSLEQ-----------------
-----------------RSL-HYKPE-E----------------ALEA----QQE-ALG-
-------------LVCVQA-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---AASSSSPLV----LGT--LEE------------------------------------
---------VP--------------------------------------TARS---TDPP
QTPQGASA---FPTTIN-F--PRWRQPNE----------------SSSS--HEEEGP---
------------S------TSRVL---------------ESLFRAVLTKKVADLV-----
-------HFLLLKYRAREPVT-KAEML--ESVIKNYK-----HCFPVIFGKASES-----
----LQLIFGID---------VKE-ADSTG---------HSYV-----------------
-------L----------------------------------VTCLGL-SYD----GLLG
---DN-QIMPKTGFL-------IIILVMIAMEGGR------APEE---EIWEELNVM---
-----EVY-DGR----EHSAYGEPRKLLTQDLVQE------KYLEYRQV-PYSDPARYEF
----LWGPRALAETS--YVKVLEYVIKVSARVRF----F-FPSLREA---ALREDEE--G
V-----------------------------------------------------------
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--------------------------------------MPRGQK---SKLRAREKR-HQA
-RS-----EAQGA-----------------------------------------------
-PD-------------AQVTAAAE------------------------------------
-----------------------------------------------------------E
-QPS-------------------------AAPFP-----P---------------LGGNA
QR----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------S-Q-DE-ERP---
-----------------------------ST-SQAQPSTDHYRKTPLDDKAILLV-----
-------QFLLRKYNMREAIT-KEDMM--KYVIKKHK-----EHFHEILRKASEL-----
----MVLAFGID---------LKE-IDPTR---------HYYA-----------------
-------L----------------------------------VSKFQH-TCD----DRLR
----GEEIMPRTGLL-------MTILCVIFMKGNR------ATEE---DIWEVLNVM---
-----GIY-ADR----KHFIYGDPKKLITQDLVQE------RYLQYQQV-ANSDPPRYEF
----LWGRRAHAETS--KMKVLEFLAKIHNTVPS----A-FPSWYEE---ALRDEEERAR
AR-FAARLRMG-AL----------------------------------------------
----------------------------------------------------------AS
--------------------VHS--R-----------------------AHFG-SFSHL-
------------------------------------------------------------
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--------------------------------------MPRGQK---SKHRAREKR-RQA
-RA-----ETQGV-----------------------------------------------
-HD--------------QATTSRG------------------------------------
-----------------------------------------------------------E
-ETT-------------------------SSSPP-----D---------------SESAP
SSLS-A-------------------------AGT----------------PKGPQG---A
Q--GTTSAAEGAIRKRSRGGGA--------------------------------------
------------------------------------------------------------
------------------A----RSRSGVGA---------------EG-Q-VQEGE----
-----------------------------NS-SQASAAAASSHTDLLTMKAELLV-----
-------QYMLYKYKMREFIK-RSKML--QKINRRYK-----EQFPEILSKASEH-----
----MEMVFGLV---------LKE-VRPNS---------HCYT-----------------
-------L----------------------------------VSNLDL-SDS----ESMR
----GDLGLPKNGLL-------MPLLGVIYLNGNH------APEE---KIWKFLNML---
-----GIY-DGR----SHFIFGEPRKLITEDLVRE------EYLEYHQV-PGSDPPRYEF
----LCGPKALTETS--KTKILQFLAKVKDSVHP----A-LQPQYEE---AWREEIESTG
ARSEA-RA-------------G---TSASTRPG---------------------------
-----------------------TAA----------------------------------
-S--------------------AAAGRSASTRP-------GTA-------A---------
------------------------------------------------------------
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------------------------------------------------------------
------------------MSQ--LSKNLGDSSPPAEAPKPP-------------------
----------VYSRPTVLMRAP-----PASSRAPPVPWDPPPVDLQA-SLAAWQAPQPAW
EAPQGQLPAPV---VPMTQPPALGGPIVPAPPLGGPMGKPPT------------------
---------------PGVLMVHP-PPPGAPMAQPPTPGVLMVHPSAPGAPMAHPPP-PGT
PMSHPP-------------------------PPGTPMAH---------------------
-----P---------P------------------PPGTPM----A-------HPPPPGTP
------------------------MAHP--PPPGTPMVHPPPPGTPMVHPPPPGTPMAHP
PPPGTP--MA-------------------QPPPPGTPMAQP---PAPGVLMAQPLTPGVL
MVQPA-------------APGAPMVQPP----PAAVM-------------------TQPP
PSGAPMAKPPGPGVLMIHPPGARAPMTQPPASG---------------APMAQPAAPPAQ
PMAPPAQPMASWAPQAQPLILQIQSQVI----R-------APPQV---P-----------
-------Q---GPQAPPAQLATPPGWQATSPGWQATPQGWQATPLTWQTTQVTWQAPA--
----------IAWQVPPPV-RQGPPPIRP-------------GPPPIRPGPPPVR---QA
PPVIRQ---APPVIRQA--------PPVIRQAPPVIRQAPPVIRQAPPVIRQAPPVIRQA
-PP---------V-----------------------------------------------
--------IRQAPPLIRQAPP-PI------------------------------------
-----------------------------------------------------------R
--------------PAPQVLATQPPLWQALPPPP-----P---------------LRQAP
QARLPAPQVQA------------APQVPTAPPATQ-------VPAAPLAGPQVPQP---V
L--PAPLSAP----------------------------------------LSAP------
-------QAAP-----------QAVH--CPSIIWQAPKGQPPVPHE--------------
------------------------------------------------------------
------------------------------------------------------------
---------IPTSMEFQEVQQ-TQ-AL--AWQAQKAP-----THFWQPLPAQEAQRQ---
----APPMVQLE-------QPFQGAPPCQKAVQIQL-PPQPPQTS--GPQAELPTLQLQP
SWQTPPAVLQAQPGPPLAAANFPLGSAKSLMTP-SGESRASCTDRRGSS-KE----RRTS
SK--ERRAPSKDRM----------IFAATFCAPKA----VSAARAHLPGTWKNSPATPET
FVPSSSVF-PAT----SQFQPASLNAFKGPSAASE----APKSLPYAL---QDPFACVEA
LPAVPWAPQPNMNASKASQAVPTLLM-ATAAAPQ----A-TATT-QE---ASKTSVEMPR
RS-----------------------GKA--------------------------------
--TRK-----KKHLEARE-DSRGHTLA-------------------------------FH
--D-WQGP----RPWENLN--LSDW--EVQSPVQ-V--LGDWEHPNTPRGLSGWEGPSTS
-RI---------------LSG---WEGPSTSWALSAWEGPSTSR-A--------------
---------LGLS---------------ESPRSPLPLVVSEVA-------------G---
VSPGSSATQDNSKVE-AQSLSPL---DERANALVQ------FLLVKD-QAKVPV--QR--
------------------------------------------------------------
----SEM---VKVIIREYKDECLEIINRANNKLECAFGYQLKEIDTKNHAYI-IINKLGY
PTGDLV-ASYLDR-PKFG---LLM----------VVLSL----------IF--------M
-KGNC----V-R--EDLIFNFLFRLGLD--VRETNGLFGNTRKLITEVFVRQK-------
---------YLEYRRIPYTEP---A--EYEFLWGPRAFLETSKMLVLRFLAKLHKK---D
------PRCWPFHYLEALAECEWEDTDEDE-PDS--S--DSA-------RGP--------
---TSRPPPR--------------------------------------------------
------------------------------------------------------------
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---------------------------------------MSDT-----------------
---------------SESVGA----------------------------GLTRFQAEASE
EDNS-LMMQTLL-------TVTQ--NLEVSEAPKSS------------------KA----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------SEVSETLNVS-------NPSEVS---------------KTT-----------
-------------EV---------------------------SEAPGSQDAA-VTQASAT
-TQLTDTQILTA----EN--KSPAADT--KVQNADPQ-------ALTISAT---------
----ETKK-----VSC--------------------------------------------
------------------------------------------------------------
--------------------------------------------------------VA--
-------------------------------GTQV-------------------------
----I-T--KSLETGA--------DASQGLADK-----------PESEAAAAQAQENQDT
RPKVK--------------------A---------------------------------K
KARKVKHLNGEEDGS---------------SDQ--ATGTTGGRRVSKALMTSMARRASRG
PIAFWARRAS----RTRLA----A------------------------------------
------------------------------------WARRALL----SLRSPKARRGKAR
RRA---------------------------------------------------------
-TKLQS-SQEPQVPP-PQDVALL---QGRANDLVK------YLLVKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LKDIIKEYTDVYPEIIERAGYSLEKVFGIQLKEIDKNDHLYI-LLSTLEP
TDAGIL-GTTKDS-PKLG---LLM----------VLLSI----------IF--------M
-NGNR----S-S--EAVIWEVLRKLGLR--PGVHHSLFGDVKKLITDEFVKQK-------
---------YLDYARVPNSNP---P--EYEFFWGLRSYYETSKMKVLKFACKVQKK---D
------PKEWAAQYREAMEADLKAAAEAAA--EAKAR----AEIRARMGIGLGSE-----
----NAAGP--CNWD-------------EADIGPWA-KARIQAGAEAKAKAQESG--GAS
AGANDSD----------------------------SASLTTTLTFGLFASFSGAGTSTSS
SSGACG-FSYK-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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---------------------------------------MSDT-----------------
---------------SE-SDA----------------------------SLTRFQAKASD
KDSD-SMMQTLL-------TVTQ--SLEFSETPKAS------------------KA----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------PEVSEAVKVS-------KGPAVA---------------KAT-----------
-------------KV---------------------------SKAPEAQEAT-AAQALPT
-TQLTDTQVLAA----ET--KNPIADT--KTQNANPR-------SVTVPAT---------
----ETKK-----VSC--------------------------------------------
------------------------------------------------------------
--------------------------------------------------------VT--
-------------------------------DTKV-------------------------
----N-T--KAPETEV--------TASQSPKDEP---------EP--EGTAAQAQENQDT
RPKVK--------------------A---------------------------------K
KARKVKHLDGEEDGN---------------SDQSQASGTTGGRRVSKALMASMARRASKG
PIAFWARRAS----RTRLA----A------------------------------------
------------------------------------WARRALL----SLRSPKA-RGKAR
RRA---------------------------------------------------------
-AKLQS-SQEPETSP-PRDVALL---QGRANDLVK------YLLAKD-QTKIPI--KR--
------------------------------------------------------------
----ADM---LKDIIKEYTDVYPEIIERAGYSLEKVFGIQLKEIDKNDHLYI-LLSTLEP
TDAGIL-GTTKDS-PKLG---LLM----------VLLSI----------IF--------M
-NGNR----S-S--EAVIWEVLRKLGLR--PGIHHSLFGDVKKLITDEFVKQK-------
---------YLDYARVPNSNP---P--EYEFFWGLRSYYETSKMKVLKFACKVQKK---D
------PKNWAAQYREPMEA-LKAAAEAAA--EAKAR----AEIRAQMGIGLGSE-----
----NAAGP--CNWD-------------EADIGPWA-KARIQAGAEAKAKAQDSG--GAS
TGANTS--------------TSANASA--SGGFSAGTGLTGTLTFGLFTGLGGSGASSND
SSGACG-FSYK-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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--------------------------------------------------------MAE-
----------------------------------------------------------GS
FS-----V-Q-------SENYSVEDMDEGSDEVG--EEEMVEGNDYE----EFGAFGGYG
TLTSFDIHI--LRAFGSLG-----------------------------PGLRILSNEPWE
LENP-VLAQTLV-------EALQ--LDPETLANETAARAA-------------NVARAAA
---S----------NRA-ARAA--------------------AAAARTAFSQV---VASH
R-------------------------------------------------VAT-------
------PQVSGEDTQPTTYAA--EAQ--------------------GPTPEPPLASPQTS
------QMLVTSKMAAPEAPAT-SAQSQTGS---------------PAQ-----------
-------------EAA----------------TEGPSSACAFSQAPCAREVD-ANRPSTA
FLGQ----------------------------NDVFD-------FTQPAGV---------
----SGMAFPRPKRPAPAQEA--ATEGPSA---------AS-GVPQTGPGREVAATRPKT
T-----------------------------K-----------------------------
------------------------------------------------------------
--------------------------------------------------------SGKA
LAKTRWVEPQNVVAAA--------AAKA-KMATS---------IPEPEGAAA--ATAQHS
AE-----------------------P---------------------------------W
ARMGGKRTKKSKHLDDEY--------ESSE-EERETPAVPPTWRASQPSLT---------
---------V----R---------------------------------------------
----------------------------------------AQLA----------------
-----------------PRPP-----------------------------M----G----
-PRSQIPSRHVLCLP-PRNVTLL---QERANKLVK------YLMIKD-YKKIPI--KR--
------------------------------------------------------------
----ADM---LKDVIREYDEHFPEIIERATYTLEKKFGIHLKEIDKEEHLYI-LVCTRDS
SAR-LL-GKTKDT-PRLS---LLL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPFLGDLRKLITDDFVKQKNPELREE
TPLSMAPSWYLEYKKIPNSNP---P--EYEFLWGLRARHETSKMRVLRFIAQNQNR---D
------PREWKAHFLEAVDDAFKTMDVDMA--EEHAR----AQMRAQMNIGDEAL-----
------IGR--WSWDDIQVELLT-WDEDGDFGDAWA-RIPF----AFWARYHQYILNSNR
ANRRA------TWRAGVSSGTNGGASTSVLDGPSTS-ST---IRTRNAARAG--------
----ASFFSWIQHR----------------------------------------------
------------------------------------------------------------
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--------------------------------------------------------MAE-
----------------------------------------------------------GS
FS-----V-Q-------SENYSVEDMDEGSDEVG--EEEMVEGNDYE----EFGAFGGYG
TLTSFDIHI--LRAFGSLG-----------------------------PGLRILSNEPWE
LENP-VLAQTLV-------EALQ--LDPETLANETAARAA-------------NVARAAA
---S----------NRA-ARAA--------------------AAAARTAFSQV---VASH
R-------------------------------------------------VAT-------
------PQVSGEDTQPTTYTA--EAQ--------------------GPTPEPPLASPQTS
------QMLVTSEMAAPGAPAT-SAQSQTGS---------------PAQ-----------
-------------EAA----------------TEGPSSACAFSQAPCAREVD-ANLPSTA
FLGQ----------------------------NDVFD-------FTQPAGV---------
----SGMAFPRPKRPAPAQEA--ATEGPSA---------AS-GVPQTGPGREVAAARPKT
T-----------------------------K-----------------------------
------------------------------------------------------------
--------------------------------------------------------SGKA
LAKTRWVEPQNVVAAA--------AAKA-KMATS---------IPEPEGAAA--ATAQHS
AE-----------------------P---------------------------------W
ARMGGKRTKKSKHLDDEY--------ESSE-EEREPPAVPPTWRASQPSLT---------
---------V----R---------------------------------------------
----------------------------------------AQLA----------------
-----------------PRPP-----------------------------M----A----
-LRSQIPSRHVLCLP-PRNVTLL---QERANKLVK------YLMIKD-YKKIPI--KR--
------------------------------------------------------------
----ADM---LKDVIREYDEHFPEIIERATYTLEKKFGIHLKEIDKEEHLYI-LVCTRDS
SAR-LL-GKTKDT-PRLS---LLL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPFLGDLRKLITDDFVKQKNPELREG
TSLSMAPSRYLEYKKIPNSNP---P--EYEFLWGLRARHETSKMRVLRFIAQNQNR---D
------PREWKAHFLEAVDDAFKTMDVDMA--EEHAR----AQMRAQMNIGDEAL-----
------IGR--WSWDDIQVELLT-WDEDGDFGDAWA-RIPF----AFWARYHQYILNSNR
ANRRA------TWRAGVSSGTNGGASTSVLDGPSTS-ST---IRTRNAARAG--------
----ASFFSWIQHR----------------------------------------------
------------------------------------------------------------
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---------------------M-------SLVSQNARR----------------------
------------------------------------------------------------
------------------GSADTA------------------------------------
-----------------------------------------------------------A
-DS---------------------------------------------------------
-----------------------------------------------------------S
D--LRDDMQA----------------PNTSGP------------P-T-------------
---------------------------------------------------SM------L
----------VPDARQGLG-GPQVPIYPQGG---------------RDSQ-AA-------
---------SDP----N--DLEV--LID-EQSRRLGA---LRFHDPLEDRSMALV-----
-------NFMRMKSQTEGSIQ--QTEM--LEFLREYS-----DQFPEILRRASAH-----
----LDQVFGLN---------LRV-LDPQT---------HTYN-----------------
----------------------L-------------------ISKRDP-QTT----GQMV
----ESLDIPKAGLL-------ALVLGHILLNGNR------AREA---SIWDLLLKV---
-----NML---NESQRINSHFGNTRNLLTTDFVRM------RFLEYWPV-YGTNPLEFEF
----LWGSRAHK--EITKM-----------------------------------------
------------------------------------------------------------
--------------------------E-------------------------------AL
K-----------------------F---VA----------------EAHDEEP-------
------------------------WSWLE-EYN------------KAMEADKAKER---S
---------------------------------------------------------QV-
AG---L--------E-FWSED---TMNDKANDLVQ------LAINVT-EELLPI--HQ--
------------------------------------------------------------
----DEL---LAHTGKEFEDVFPNILSRATLILDLFYGFSLIEVDTSEHIYL-LVQQPES
EEEQVM-LESLGR-PTQE---YVM----------PILGL----------IF--------L
-MGNR----V-K--EANVWNLLCRFGVD--VGRKHAI--------TCKLMRQR-------
---------YLECRPLSYSNP---V--EYELLWGPRAHLETTKMKALEYMARLYRK---R
------PQDWPEQYREAVE-----------DEEVRARSEANAMFF----FDP--------
---V--------------------------------------------------------
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--------------------------------------MPRGQK---SKHRAREKH-RQA
-RA-----ETQGL-----------------------------------------------
-HD--------------QATTSGG------------------------------------
-----------------------------------------------------------E
-ETT-------------------------SSSPP-----D---------------SESGP
SSSS-A-------------------------AGT----------------SKGPQG---A
Q--GTTSAAAGAVRKRSGVGRA--------------------------------------
------------------------------------------------------------
--------ARSRSGVGAAA----CSRSGIGA---------------EG-Q-VR-EGE---
-----------------------------NS-SQASAAAESSHTDLLTWKAEVLV-----
-------QYMLCKYKMRALIK-RSEML--KAVTRRYR-----EQFPEILSRASER-----
----MELVFGLV---------LKE-VRPNS---------HCYT-----------------
-------L----------------------------------VSNLDL-SDS---ESM-R
----GDWGLPKNGLL-------MPLLGVIYLNGNH------APEE---KIWKFLNML---
-----GIY-DGR----SHFIFGEPRKLITEDLVRE------GYLEYRQV-PGSDPPRYEF
----LWGPKLLTETS--KMKVLQFLAKVKDSGHT----A-FLSQYED---AWREEVESTG
DR-GAARAGPS-ASLR--P-----------------------------------------
--------------------------G-------------------------------TA
--------------------A---------------------------------------
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------------------------------------------

------------------------------------------------------------
------------------MSQ--LSKNLGDSSPPAEAPKPP-------------------
----------VYSRPTVLMRAP-----PASSRAPPVPWDPPPMDLQA-SLAAWQAPQPAW
EGPPGQLPAPV---APMVQPPALGGPIVPAPPLGGPMGKPPT------------------
---------------PGVLMVHP-PPPGAPMAQPPTPGVLMVHPSAPGAPIAHPPP-PGT
PMSHPP-------------------------PPGTPMPH---------------------
-----P---------P------------------PPGTPM----V-------HPPPPG--
--------------------------------------------TPMAHPPPPGTPMAHP
PPPGTP--MA-------------------HPPPPGTPMAQP---PAPGVLMAQPLTPGVL
MVQPA-------------PPGAPMAQPP----PAAVM-------------------TQPP
PSGAPMPKPPGPGVLMIHPPGVRAPMTQPPASG---------------APMGQPVAP---
----PAQPMASWGPQGQPLILQIQSQVI----R-------APPQV---P-----------
-------QV---PQAPPAQLGTPPGWQATSSGWQATPQGWQATPLTWQTTQVTWQAPA--
----------IAWQGPPPM-RQGPPPIRP-------------SPPPIRPGPLPVR---QA
PPVIRQ---APPVIRQAPP-VIRQAPPVI--------------RQAPPVIRQAPPVIRQA
-PP---------V-----------------------------------------------
--------IRQAPPLIRQAPP-PI------------------------------------
-----------------------------------------------------------R
--------------PAPQVMATQPPLWQPLPPPP-----P---------------LRQAP
QARLPAPQVQA------------APQVPTAPPATQ-------VPAAPPAGPQVPQP---V
L--PAPLSAP----------------------------------------LSA-------
----------P-----------QAVP--CPSIIWQAPKGQPPVPHE--------------
------------------------------------------------------------
------------------------------------------------------------
---------MPTSMEYQEVQQ-TQ-AL--AWQAPKAP-----THFWQPLPAQEAQRQ---
----PPPMVQLE-------QPFLGGPPSQKAVQIQL-PSQQAQAS--GPQAELHALPIQP
PWQAPPAVLQAQPGAPVAASNFPPGSAKSLMTP-SGECRASSIDRRGSS-KE----RRTS
SK--ERRGPSKDRM----------IFAATFCAPKA----VSAARAQPPGSWTSLPAAPET
FAASSGVF-PAT----SQFQPASLNSFKGPSVASE----TPKSLPYAL---QDPFACVEA
LPAVPWVPQANMNASKASQAVPTLLM-ATAAAPQ----A-AATT-QE---ASKTTIEPPR
RS-----------------------GKA--------------------------------
--TRK-----KKHLEAKD-NSRGHRLP-------------------------------FR
--D-WQGP----RPWEN----LSGW--EVQSPVQ-V--LGDWEHPNTPRGLSGWEGSSTS
-RI---------------LSG---WEGPSTSWA---------------------------
---------LGFS---------------EGPGSPLPWIVSEVP-------------S---
VSPGSSATQDDSKVG-ARPLSPL---DER--ALVQ------LLLVKD-QAKVPV--QR--
------------------------------------------------------------
----SEM---VKVIIREYKDECLDIINRANSKLGCAFGYQLKEIDTKSHAYI-IINKLGY
PTGNLV-ASYLDR-PKFG---LLM----------VVLSL----------IF--------M
-KGNC----V-R--EDLIFHFLFKLGLD--VRETNGLFGNMKKLITEVFVREK-------
---------YLEYRRIPYTEP---A--EYEFLWGPRAFLETSKMLVLRFLAKLHKK---D
------PQSWPFHYLEALAECEWEDTDEDE-SDT--GDSD---------HDP--------
---ASRPPPR--------------------------------------------------
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-----------------------------------------------------MSEQSKD
LSD---------------------------------------------------------
------------------------------------------------------------
--------PNF----------------------------A---------------GEA-P
DCEM--------------------------QDS-----------------DAVPVG---I
P--PPASLAAN----------LAGPPCAPEGL------------M---------------
----AAPQAS--------------------------------------------------
------PPP--------------EERIEDVD---------PKIL-QQA-A-EE--GR---
----------------------AHQPQ--SPARP--I-PAPPAPAQLVQKAHELM-----
-------WYVLVKDQKRMVLW-FPDMV--KEVMGSYK-----KWCRSILRRTSVI-----
----LARVFGLH---------LRL-TNLHT---------MEFA-----------------
-------L----------------------------------VKALSPEELD-----RVA
----LNNRMPMTGLL-------LMILSLIYVKGRG------AREG---AVWNVLRIL---
-----GLR-PWK----KHSTFGDVRKIITEEFVQQ------NYLKYQRV-PHIEPPEYEF
----FWGSRANREIT--KMQIMEFLARVFKKDPQ----A-WPSRYRE---ALEQARALRE
ANLAA----------------------------------QAPRSSVSED-----------
------------------------------------------------------------
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--------------------------------------MPHAS-----------------
-----------------KRL-CLAFR-W----------------LCVL-----NE-EQ--
------------------------------------------------------------
-----------------------------------------------ELMDAEIP----T
TE-------------------------------------DE-------------------
---------------------------------------------------------DIP
STSSAS--SPVI----PGT--PEEEEVPD-------------------------------
-----PGIQNS--------------------------------------PQKS---PQGV
CSPQTSLR----------A--PPWSIADK----------------KSSSQ-EDESSS---
------------S------SL----------------------SFPLSEKVTELV-----
-------HFLIFKYRLKEPIT-KAEML--EVVIKTYN-----NHFPVIFTRACRC-----
----LDVIFGID---------VNE-MDPTS---------HSYV-----------------
-------L----------------------------------VNSLDV-TYD----DM--
VG-DY-QSMPKNGLL-------VMILGLIFIEGNH------ASEE---DIWGFLNMM---
-----GMY-PGR----EHYIYGDPSE-FTRDWVQE------NYLEYRQM-PNSDPPRFEF
----L-GPRAYAETS--KVNVLK-------------------------------------
------------------------------------------------------------
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----MEIIFGLD---------LQK-VDPAN---------HRYD-----------------
-------L----------------------------------LIKLGL-TYD----GMLH
----GEVGVPKTGFL-------LLILGVIFMKGNR------ATED---EVWEVLSVI---
-----GVY-SGR----KHFMFGEPRKLITEDFVKE------KYLEYRQV-ANTDPAQFEF
----LWGPRAHAETT--KMKLLEFLAKVHGIDPS----S-FPSQYEE---ALQDEEERAQ
ASSA-RGLSFH-GYPKF-------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
--------------------------------------------------------MAE-
----------------------------------------------------------GS
FS-----V-Q-------SESYSVEDMDEGSDEVR--EEEMVEGNDYE----EFGAFGGYG
TLTSFDIHI--LRAFGSLG-----------------------------PGLRILSNEPWE
LENP-VLAQTLV-------EALQ--LDPDTLANETAARAA-------------NVARAAA
---S----------NRA-ARAA--------------------AAAARTAFTQV---VASH
R-------------------------------------------------VAT-------
------PQVSGEDTQPTTYAA--EAQ--------------------GPTPEPPLASPQTS
------QMLVTSEMAAPGAPVT-STKSQTGS---------------PAQ-----------
-------------EAA----------------TEGPSGACAFSQAPCAREVD-TTRPSTA
FLGQ----------------------------NDVFD-------FTQPAGV---------
----SGMAFPRPKRPAPAQEA--ATEGSSA---------AS-GVPQTGPGREVAATRPKT
T-----------------------------K-----------------------------
------------------------------------------------------------
--------------------------------------------------------SGKA
LAKTRWVEPQNVVAAA--------AAKA-KMATS---------IPEPEGAAA--ATAQHS
AE-----------------------P---------------------------------W
ARMGGKRTKKSKHLDDEY--------ESSE-EEREPPAVPPTWRASQPSLT---------
---------V----R---------------------------------------------
----------------------------------------AQLA----------------
-----------------PRRP-----------------------------V----A----
-PRSQIPSRHVLCLP-PRNVTLL---QERANKLVK------YLMIKD-YKKIPI--KR--
------------------------------------------------------------
----ADM---LKDVIREYDEHFPEIIERATYTLEKKFGIHLKEIDKEEHLYI-LVCTRDS
SAR-LL-GKTKDT-PRLS---LLL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPFLGDLRKLITDDFVKQKNLELREG
TPLSVAPSWYLEYKKIPNSNP---P--EYEFLWGLRARHETSKMRVLRFIAQNQNR---D
------PREWKAHFLEAVDDAFKTMDVDMA--EEHAR----AQMRAQMNIGDEAL-----
------IGR--WSWDDIQVELLT-WDEDGDFGDAWA-RIPF----AFWARYHQYILNSNR
ANRRA------TWRAGVSSGTNGGASTSVLDGPSTS-ST---IRTRNAARAG--------
----ASFFSWIQHR----------------------------------------------
------------------------------------------------------------
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------------------------------MPR---------------------------
----------------------SKKSK-------------------------------AR
--------------------GGDKCP-QAQGQTQS---CGGAQAIAAAEEEST--TSSL-
---------------------QCEDTTQS-LPGAESCSTSQEPQ-R-------------I
---------PTIA-----------------AAAVFSYTRSSEA-------------FDGQ
YKYRALAYEVPPFTE-TPGTDCL---TRKASLLEQ------YLLYKY-KMKQLM--MK--
------------------------------------------------------------
----EDM---LKIIHQSHHDRFAEILKRASERIELVFAVELKEVDSVVPCYN-LVSKLKL
PNNGRV-RGGRGL-PKTG---LLM----------NLLGM----------IF--------L
-KGNC----A-A--EEDIWKYLGTMRVY--AGRKHLIYGEPRKLITKDLVRLK-------
---------YLEYRQVANSDP---P--RYEFLWGPKAHLETSKMKVLEFLAKVNDA---V
------PSDFPTYYEEALRDEEEKAQGMHA-ARPDTTVKVSTPPRDMLSIII-PPVRK--
------YVKF---LPPDRKI----------------------------------------
------------------------------------------------------------
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--------------------------------------MPRAQK---SKLCTGEKR-HQA
-QG-----GTQPQ-----------------------------------------------
-RG-------------AQTPAATE------------------------------------
-----------------------------------------------------------Q
-AFP-------------------------SSASP-----P---------------FEVLT
QRNP-A------------------------ARSRS-------A-------PKRSQR---A
V--SATTKSA-G------------------------------------------------
------------------------------------------------------------
-----------------VS----RTRSYKGA---------------DC-Q-VE-KKQ---
-----------------------------SS-VQSPLSIVQSQGDPVSKTASVLV-----
-------EFLLHMSRMKRPIM-KADML--KFINKKHK-----HRFVEILKRASFS-----
----LEVVFGVD---------LKE-VDPTK---------HSYV-----------------
-------L----------------------------------VSKMNL-PNN----GTIN
----RGRGFPKTGLL-------MNLLGVIFLKGNC------AAEE---KIWEFLSKM---
-----RVY-AGK----RHFIFGEPKKLITQDLVKL------KYLEYRQV-PNSDPPRYEF
----LWGPRAHAETN--KMRVLEFWAKINQTVPS----A-FQPWYEE---ALRDEQERAE
AT-VTLQAETD-AT----------------------------------------------
----------------------------------------------------------AS
--------------------ACSRAC-----------------------PAA---PPTPS
EVE---------------PDP-SH-------------CD---------------------
------------------------------------------------------------
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--------------------------------------------------------MAE-
----------------------------------------------------------GT
YS-----V-Q-------SGNSNVEDMDEGSHQVR--EEEMVGGNDYE----EFGAFGGYG
TLTSFDIHL--LRAFGTLG-----------------------------SGFHILANEPWE
LENP-VLAQTLV-------EALQ--LDPETLANETEARAA-------------NVARSAA
---S----------NRA-ARAA--------------------ATAARRSFTQV---VANH
L-------------------------------------------------VPT-------
------QLATGDSAQPMTYSE---AQ--------------------GPTPEAILASPPKS
QM---SQMSVISEMAAPGAPTI-STQSQTAS---------------LDHQ-AA-------
--------AEGPGTAR----------------AEIPSTACVFSQAPSASETD-ATWPQAA
FLGQ----------------------------KDVFD-------FTQPAGV---------
----SGMAFTRPKRPAPSQEA--ATEDPST---------AS-GVPQAASAKEVAATRPKT
T-----------------------------K-----------------------------
------------------------------------------------------------
--------------------------------------------------------SGKA
VAKTRWVEPQNVAATA--------ATNT-KMATS---------TPEPEGAAA---TAQQS
GE-----------------------P---------------------------------W
ARMGGKRTKKSKHLDDEC--------ESSE-EEREPPPVPATWRASQTPVT---------
---------A----R---------------------------------------------
----------------------------------------AQVG----------------
-----------------PRPI-----------------------------M----A----
-PRPQTPSRHILCLP-PRNVTLL---QERANKLVK------YLMIKD-YKKIPI--KR--
------------------------------------------------------------
----SDM---VKDVIREYDEHFPEIIERATYTLEKKFGIHLKEIDKEEHLYI-LVCTQDS
SAR-LL-GKTKDT-PRLS---LLL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPFLGDLRKLITDDFVKQK-------
---------YLEYKKVPNSSP---P--EYEFLWGLRACHETSKMRVLRFIAQNQNR---D
------PREWKAHFLEAVDDAFKTMDMDMA--EEHAR----AQMRARMNIGDEAL-----
------IGR--WSWDDIQAELLT-WDEDGDFGDAWA-RIPF----AFWARYHQYILNSSR
ANRRA------TWRAGVSSGTNGGASTSILDGPSTS-ST---IRTRNAARAG--------
----ASFFSWIQQR----------------------------------------------
------------------------------------------------------------
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--------------------------------------MPRGQK---SKLRAREKR-RQA
-RG-----ETQHL-----------------------------------------------
-RD-------------AQATAAEG------------------------------------
-----------------------------------------------------------E
-E----------------------------SPSP-----P---------------PGDNL
QSSP-A------------------------YGSGR-------K-------SQGSRK---A
P--STTTTSA-G------------------------------------------------
------------------------------------------------------------
-----------------VS----CTRSDEGA---------------KS-H-DE-EQP---
-----------------------------GT-SLAMPSTDYSCRSPLDQKAILLV-----
-------QFLLRKYNMREPIT-KKDMM--KHVIKRYK-----EHFHEILRKASEL-----
----MVLAFGID---------VKE-VDPTR---------HCYV-----------------
-------L----------------------------------ISKFQR-TSD----ERLR
----GEEIMPKTGLL-------MTILCVIFMKSNC------ATEE---EIWEVLNVM---
-----GIY-AGK----NHFIYGEPKKLITKDLVQE------RYLVYRQV-ANSNPPRYEF
----LWGPRAHAETS--KMKVLEFLAKIHDTVPS----A-FPSWYEE---ALRDEEMRAR
AR-FAAMVRTG-AL----------------------------------------------
----------------------------------------------------------AN
--------------------MHS--G-----------------------ANF--------
------------------------------------------------------------
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--------------------------------------MPRGQK---SKLRAREKR-RQA
-RE-----DIQDL-----------------------------------------------
-VD-------------AQATAASE------------------------------------
-----------------------------------------------------------E
-EIP-------------------------SSSSL-----S---------------FKGIP
QSLP-A------------------------AGTHS-------M-------PQEPHR---A
L--STSIHAV-T------------------------------------------------
------------------------------------------------------------
-----------------VS----YKTSDKDD---------------NS-K-DE-ESP---
-----------------------------NF-SLAQLATENLHRGPIDEKMIILV-----
-------HYLLHKYEMKEPIT-KADML--RNVIQVYR-----SHYPEILSKASEH-----
----LELVYGLD---------LKE-VDPNR---------HTYI-----------------
-------L----------------------------------VNKLEL-SCS----RTLP
----DDRGLPKTGLL-------MTILGVIFTKGNC------ATEE---EVWEVLNVM---
-----GIY-AGR----EHLIFGEPRKLITKDLVKE------KYLEYWQV-PHSNPPRYEF
----LWGPRAYTETT--KMKVLEFLAKVHHTVPS----A-FPFWYEE---ALRDEEERAQ
AR-VAARARIS-AM----------------------------------------------
----------------------------------------------------------AS
--------------------ARS--R-----------------------AMFS-VSSCPK
------------------------------------------------------------
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--------------------------------------------------MLQKPE---S
G--------------------------------------------------ALPIL----
-------RAE----------------------------GEKDGGRDGETQALA-----A-
-SQE-------------------TPGEHLGA---------------RREE-G--------
----------------PAEPALAPRGA--RT-LAAKASARRRAYRRLDRTVAELV-----
-------QFLLVKDKKKSPIT-RSEMV--KYVIGDQK-----DLSPEIIARAAEH-----
----LRHVFGFE---------LKQ-LGRKQ---------HTYI-----------------
-------L----------------------------------INKLKPLEEE----EE--
-EEDLGGGGPRLGLL-------IMILGLIYMKGNS------ARET---QVWEMLRRL---
-----GVR-PSK----YHFLFGYPKRLIMEDFVQQ------RYLSYRQV-PHSNPPECEF
----SWGPRSNLEIS--KMKVLGFVAKLHKKEPQ----H-WPVQYRE---ALADEADRAR
AKAR-AEASMRARA--------R--ARATETAG---------------------------
------------------------------------------------------------
-IS----P------W---------------------------------------------
------------------------------------------------------------
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---------------------------------------MSDT-----------------
---------------SE-SGA----------------------------DPARSQGKASE
KDSG-SMMQDLL-------TVTQ--NLEVSETPKAK------------------KA----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------PEVSEAAKVP-------KASGNP---------------KAT-----------
-------------EV---------------------------SKAPEASEAA-ATQASPT
-TQLSETQVLAA----EN--KSPAADT--KTQKADLQ-------AMTMPAT---------
----QTKT-----VSS--------------------------------------------
------------------------------------------------------------
--------------------------------------------------------VT--
-------------------------------DSKV-------------------------
----N-T--KTPETEA--------PASQSGADEP---------EP--EGAAVQVQENQDT
RPKVK--------------------A---------------------------------K
NTEKGKHLEGEEDGN---------------SDQSQTSETTGGRRVSKALMASMARRASRG
PIAFWARRAS----RTRLA----A------------------------------------
------------------------------------WARRALL----SLRSPRARRGKAR
RRA---------------------------------------------------------
-AKLQS-SQEPEAPP-PRDVALL---QGRANDLVK------YLLAKD-QTKIPI--RR--
------------------------------------------------------------
----SDM---LKDIIKEYTDVYPEIIERAGYSLEKVFGIQLKEIDKNDHLYI-LLSTLEP
TDAGIL-GTTKDS-PKLG---LLM----------VLLSI----------IF--------M
-NGNR----S-S--EAVIWEVLRKLGLR--PGIHHSLFGDVKKLITDEFVKQK-------
---------YLDYARVPNSNP---P--EYEFFWGLRSYYETSKMKVLKFACKVQKK---D
------PKEWAAQYREAMEADLKAAAEAAA--EAKAR----AEIRAQMGIGLGSE-----
----NAAGP--CNWD-------------EADIGPWA-KARIQAGAETKAKAQESSGASAG
TGAGASASAGTSVSTSGTAGSGANAGA--SGGFSTNPSLTASLTFGLFAGLSGAGASNSS
SSGACG-FSYK-------------------------------------------------
------------------------------------------------------------
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---------------------------------------MSEKMDCGAGLLGFQA-----
--------------------------------------------------------EASV
EDST-LLMQTLM-------EAIQ--IS-EAPPTSQA--TA--------------------
------------------------------------------AASAPNASPQSSQPPAV-
S------------------------------------------------EMAD-------
------TQALATATKPKT------------------------------------------
-----------------------------AF---------------KVQ-----------
-------------NAT----------------TKGPNAAYDFSQAFNAKETP-NILPTAH
F-------------------KSQNAPA--KGPNAAYD-------FSQAAPT---------
----GELTANKSDMAFKAQNTT-TKVVPNA---------A-YNFSQSLNASEMVNPQPKT
------------------------------------------------------------
----------------------------------------------AFKAWNDTTTAPTA
-------------------------------DPQT-----------QNV-----------
----NPA---KMATSH--------TDIEADPSPG---------ICESDGAAAQTSADGSQ
AQNLE--------------------S---------------------------------R
TIIRGKRTRKINNLNV---------EESSSGDQRRAPLAPGTWRSAPVPVTT-QSPPGAP
PNVLWQTPLA----WQNPS----GWQNQPTRQTP----P-ARQSPPTRQTPPAWQNPVAW
QNPVIWPNPVIWQNPVIWPNPI-VWPGPVVWPNPLAWQNPPGWQTPPGWQTPPGWQGPPD
WQG---PPDWPLPPDW-PLPP-DWPLP-ADWPLPPDWIPTDWPVPPDWQNLRPSPNLRP-
-SPNSRASQNLGASQ-PRDVALL---QERANKLVK------YLMLKD-YTKVPI--KR--
------------------------------------------------------------
----SEM---LRDIIREYTDVYPEIIERACFVLEKKFGIQLKEIDKEEHLYI-LISTPE-
SLAGIL-GTTKDT-PKLG---LLL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPLLGDLRKLLTYEFVKQK-------
---------YLDYRRVPNSNP---P--EYEFLWGLRSYHETSKMKVLRFIAEVQKR---D
------PRDWTAQFMEAADEALDALDAAAA--EAEAR----AEARTRMGIGDEAV-----
------SGP--WSWDDIEFELLT-WDEEGDFGDPWS-RIPF----TFWARYHQNARSRFP
QTFAG---------------------P--IIGPGGTASA------NFAANFGAIGF----
--------FWVE------------------------------------------------
------------------------------------------------------------
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--------------------------------------------------------MAHP
PPPGTP--MA-------------------QPPLPGTPMAQP---PAPGVLMAQPLTPGVL
MVQPP-------------APGVPMPQPL---PPAALM-------------------TQPP
PSAAPLAKPPGPSVLMMHPSGSGAPITQPPVSG---------------ALMAQPVAP---
----PAQPMASWAPQGQPLILQIQSQVI----R-------APPQV---S-----------
-------Q---GPHTHQVQLATTPGWQATSPGWQAPPQAWQATPLTWQTTQVTWPAPT--
----------IAWQAPPPM-RQGPPPIRP-------------GPPPIRPGPPPM------
------------------------------------------ARQAPSVTRQVQPVTRQA
-PS---------V-----------------------------------------------
--------SRQAPPLTRQAPP-LI------------------------------------
-----------------------------------------------------------R
--------------PGQQILATQPQLWQALPPPP-----P---------------LRQAP
QARLLAPQVQG------------VPQVPTASIVTQ-------VPAAPPAGPQVPQP---V
L--PGPLSVS----------------------------------------LPGPLP----
-GPQAA-SAVPQASQ-------QAVH--CPSIIWQAPKGQAPVPHE--------------
------------------------------------------------------------
------------------------------------------------------------
---------LPTSMEFQEVQQ-AQ-AL--AWQTPKAP-----THFWQPLPAQETQGQ---
----PPRIVQLE-----Q-QPFRGVWASQKGPQTQL-HPHQAQPM--GPQAEMPTMQLHP
SWQGPPPMLQAQPGAPVAGASFPRGQPKSLMTP-SGEGRASSSEHKGPS-RE----RRTS
TK--EKKGPSKDRM----------IFAGTFCGPRA----VPASRAHLPNAWKNLPGTSYT
FPATSRVF-PST----SHFQPASSNAFTGPSATSE----SPKALPLAL---QDPYACVET
LTAAPWAPQPNGNVSNASKAEPRILM-ATAPATQ----A-TATV-PE---ASKT-VEPPR
RS-----------------------GKV--------------------------------
--TRK-----KKHLEPKE-DNRGHRMA-------------------------------PR
--D-WHGS----QPWEGSS--LSDW--EIQSSLQ-A--LGDWGYPSTSYGPSGWESSSMS
-RV---------------LSG---WEGPSTSWAQGTWEGPSTSR-G--------------
---------LGHC---------------ESSDSPQPLVASEVP-------------C---
LFHSLRATQEDPRGE-TQQLCPL---DVRANALVQ------FLLVRN-QVKVPI--QR--
------------------------------------------------------------
----SEM---VSAIIREYEDQCSDIISRANRKLECNFGCQLKEIDAKAHSYV-VINQLGH
HRCDFL-APFTDR-PKFG---LLM----------VVLSL----------IF--------M
-KGNC----V-R--ENLIFSLLFRLGLD--VRETNAVFGNMKKLITDVFVRHR-------
---------YLEYRRVPCTEP---A--EYELLWGPRAFLETSKFLVLRFLAKLHKR---D
------PQCWPFHYLEALAEFESEDSDADE-PDA----SDDC-------DDP--------
---TSSAPPH------L-------------------------------------------
------------------------------------------------------------
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--------------------------------------MPRGQK---SKLRAREKR-RQA
-QG-----EPQGL-----------------------------------------------
-VG-------------TQSTAAKV------------------------------------
-----------------------------------------------------------E
-E---------------------------SPDSP-----V---------------SGDTP
PSFR-A-------------------------AGT----------------SQEPQG---S
P--AT-SSPAAG------------------------------------------------
------------------------------------------------------------
-----------------VS----RRKSNVGA---------------KG-Q-VE-KNK---
-----------------------------NS-SRASTSSESARQDLLTRKVGMLM-----
-------QFLLEKHTMRAPIR-RADML--KLVNKRYR-----EHFPEILRRASEH-----
----MELVFGLE---------LKE-VKPGS---------CSYI-----------------
-------L----------------------------------ISSLDL-SSD---GSV-S
----SGHDFPKNGLL-------MPLLGVIFLTGNR------ASEE---DIWEFLNIL---
-----GIY-DGR----RHLVFGDPRKLITQDLVQE------KYLEYRQV-ANSDPPRYEF
----LWGPRARAEIS--KMRVLEFLAKVHDTVPS----A-FPFHYEE---ALRDEEERAR
AR-AAAGAAST-TE----------------------------------------------
----------------------------------------------------------AG
--------------------ARS--R-----------------------AKSS-RSAP--
PP----------------------------------------------------------
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-----------------------------------------EPSWKA---AKGAFIESRR
FSSSWSCHSP-PSRFVSCQLFCPNSCLEVIMPR---------------------------
----------------------GQKSK-------------------------------SR
--------------------SRAKRH-QAREEEAA---SP---------------PV---
----------------------SQGNPP---------RESQGIA-T-------------C
---------GSPD---A----------------GVSSIASGVG---------R--SVVRA
EKKISNPSQAAASTH-PTHKDPF---MKKTGMLVE------FLLDKF-KMKEPV--TQ--
------------------------------------------------------------
----DEM---LKIVNKKYKQHFSEILRRVSARLELVFGLELKEVDPNTHSYV-LVGKLGL
STEGSL-IGIWGL-PKTG---LLM----------LILGV----------IF--------M
-KGNR----A-T--EQEIWQFLNGMGIR--AGKKHLIYGDPGEFITKDLVQEN-------
---------YLEYCQVPGSDP---P--CYEFIWGPRAHAETTKMKVLELLAKINGT---T
------ASAFPNLYKLALRDQAKGEGRSIA-R---V-------------HPKATSNISSH
K-----------------------------------------------------------
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------------------------------------------

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--------------------------------------MSHG-Q----------------
-----------------KSD-SCNLK-E----------------DLQA----PRE-AQG-
-------------LVGLQVPIVEE------------------------------------
-----------------------------------------------------------E
E-AT-----------------------STTN-----------------------------
------------------------------------------------------------
--TSFSSLSPLT----PGS--PEDL---P---------------------ATG-------
----------I--------------------------------------LSLF-------
QSFQIAGS---SSTANT-V--TLSSHQ--------------------------EED----
-----------------PSTLQTPL------------NPESLLTEVLQNKVYDLV-----
-------QYLSIKYATKEPIT-KAEML--ESVIREHK-----DHFPVIFKKACES-----
----LETIFGIE---------VKE-VDPTS---------HSYV-----------------
-------L----------------------------------VKSLDL-TYD----GMLS
---D-DQVMPKTGIL-------ILILGIIFMEGNR------ASEE---RILEIMNMV---
-----GVH-DGK----NNFIYGDPRKLITEDLVQE------KYLEYQQV-PNSDPPRYEV
----LWGPRAHAETT--KMKVLKFLARLNGTDPT----S-FTNLYEE---ALRDEREKAQ
AEVSSDD-TTA-------------------------------------------------
------------------------------------------------------------
-----------------------TT--------D----------------ESS----SV-
------------------------------------------------------------
---------LSS---------------------SFSC-----------------------
------------------PE----------------------------------------
------------------------------------------------------------
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--------------------------------------MPRGHK---SKLRAREKR-RHN
-RG-----ETQGL-----------------------------------------------
-TS-------------AQATTAEE------------------------------------
-----------------------------------------------------------E
-ETT-------------------------PASSP-----V---------------LGDAP
SSSP-V-------------------------PGT----------------SQEPQE---A
L--AT-TSAAAA------------------------------------------------
------------------------------------------------------------
-----------------VS----RPRSNVGA---------------KG-Q-VE-KNK---
-----------------------------NS-SRASTSPESARKDLLTRKVGMLV-----
-------QFLLYKYKLRAPIR-RADML--KLVNKRYR-----EDFPEILRRASEH-----
----MELVYGLE---------LKE-VKPGS---------CSYI-----------------
-------L----------------------------------ISSLDL-SSD---GSV-S
----SGHDLPKNGLL-------MPLLGVIFLRGNC------ASEE---DIWKFLNIL---
-----GIY-DGR----RHLVFGEPRKLITHDFVQE------KYLEYRQV-ANSDPPRYEF
----LWGPRARAEIS--KMRVLEFLAKIHDTVPS----A-FPCHYEE---ALRDEEERAR
AR-AAAGAAST-TK----------------------------------------------
----------------------------------------------------------AG
--------------------ARS--R-----------------------AKSS-RSAP--
PP----------------------------------------------------------
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-------------------M----------------SG----------------------
------------------------------------VYRPKRQ-----------------
-----------------RYT-LEQSP-Q--------------------------------
------------------------------------------------------------
-------------------------------------------------------D---E
VEEH----------------------------VA-------------------------A
----------------------------------------------APSSMRIQSVGLSA
------------------------------------------------------------
--------------------------------------------------------PGTP
SESQNPEQ---TTTTSS-V-----------------------------------LIT---
------------V------DEESTQ------------EEGNSSSAILQKKVAEMM-----
-------EFLLTKYQTKEPTV-KIDM---HRIVEGYE-----ACFPIIFQRACEC-----
----IELVFGLT---------VKE-DDHLD---------NGYV-----------------
-------F----------------------------------CSTLGL-TCE----GI--
LK-ND-HGVPKGGLL-------MVVLSTIFREGNC------ATEE---RVWKVLSRI---
-----GVY-PGI----EHAIYGEPRKFLTQELVQA------KYLEYRRV-PNCHPALYEF
----LWGPRAHEETS--KMKFIEFWAQVNDTIPS----A-FPDYYEE---ALKEERAKAM
ASSSASPTAAE-------------------------------------------------
------------------------------------------------------------
-----------------------DS------CAK----------------WS---L----
------------------------------------------------------------
---------SSP---------------------KI-------------------------
------------------------------------------------------------
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--------------------------------------------------MLQKPT---I
R--------------------------------------------------GRP------
------------------------------------------------------------
--------GSGEE----------APSTSRVT---------------GGSQ-G--------
------------------SMSASFRGT--RT-SQATPAAGPRTQKQLELKVVELV-----
-------QFLVIKDQKKIPIK-RTDIV--KHVIGDYK-----DIFSDLLKLAAQR-----
----LEYVFGYK---------LVE-LEPKS---------NSYI-----------------
-------L----------------------------------INTLEPVEED----AEVR
----GDQGTPTTGLL-------MIVLGLIFMKGNT------VKET---EVWDFLRRL---
-----GVY-PTK----KHLIFGDPKKLITEEFVRQ------RYLEYRRI-PHTDPIDYEF
----QWGPRTSLETS--KMKVLKFVAKVHNQDPK----D-WPAQYCE---ALAEEEGRAR
PQSG-GPAPS--S-----------------------------------------------
------------------------------------------------------------
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--------------------------------------MPLEQ-----------------
-----------------RSQ-HYKPE-E----------------GLEA----RGE-ALG-
-------------LVGAQAPATEE------------------------------------
-----------------------------------------------------------Q
E-T---------------------------------------------------------
------------------------------------------------------------
----ASSSSTVV----EVT--RGE------------------------------------
---------VL--------------------------------------AAES---PGPP
QSPQGAST---LPTTNN-Y--TLWSQSDE----------------DSSS--QEEEGP---
------------S------TFPDL---------------ESGFQAALSRKVAE LV-----
-------HFLLLKYRAREPVT-KAEML--ESVMRNCQ-----YFFPVIFSKASDS-----
----LQLVFGIE---------LME-VDPVG---------HLYI-----------------
-------F----------------------------------VTCLGL-SYD----GLLG
---DN-QIMPKAGLL-------IIVLAIIAKEGDC------APEE---KIWEELSVL---
-----EVF-EGR----EHSIFADPRKLLTQDFVQE------NYLEYRQV-PGGDPACYEF
----LWGPRALLETS--YVKVLYHMLKISGGPHF----S-YPPLHEW---ALREGEE---
------------------------------------------------------------
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--------------------------------------MNPSE-----------------
-----------------NSRN-VN-Q-D----------------STQS----QRE-TRD-
-------------LEAGEEQ----------------------------------------
------------------------------------------------------------
--------------------------------------A---------------------
------------------------------------------------------------
--------TATT----SG------------------------------------------
---------------------------------------------------DV---LDSS
---QRA--------SFP-Y--IAGV------------------------P-SVEASS---
------------S------QIREDF------------DPDAPSQHILNSKTIDLI-----
-------LFLLLKYRRKQQTC-KAEIL--YMVIRGYE-----DYFPAIFTKASDC-----
----LRLTFGLE---------VIE-RNPRV---------HSYS-----------------
-------L----------------------------------VNALGL-TYD----GM--
HH-GF-LGVPKIGLV-------IIVLCIIFIEDNC------ASEQ---ELWRILNNM---
-----GLY-AGR----DHFIYGDPGVLITEHFVQE------GYLECRQV-PGSDPPTREY
----LWGPRAHAETT--KMKVLKHFASIVKQDPR----S-YPTRYAD---ALKDEIDRV-
------------------------------------------------------------
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------------------------------------------------------------
--------------------------------------VPGGQK---KGD-Y--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---K-I-------------------------KGN----------------LQSKSK---K
Q------------------------------------------------GVGDTSV----
PTAEKATSHS----------------------------VIPDFSLE--ILAIT-----MQ
SNIQS-----SQQ----------TGSSSAAA---------------ASSS-KPVMG----
-----------------------------SY-NEDEEMPSTSYISTLKKKAVELL-----
-------YFLNFKLQ-KEPIT-KDEVL--KMAVREYK-----DHYYEIFKRAWGS-----
----MQMIFDMD---------AKE-EDPSG---------NSHS-----------------
-------L----------------------------------TKIFNLTYDG-----LL-
----NSCGTPKTGLL-------ILILGVIYVEGNC------ASEE---RIWEVLNMM---
-----DIY-SGS----NDFFLGEPRKLITKDLVEE------SYLVYRQV-LNSEPPRYKF
----LWGPRAYLEIS--MMEVFDFFSKSNTMYAS----A-LSYQHEE---RDEEE--KTP
PM-------FSDRD--------DTFSTISSNP----------------------------
------------------------------------------------------------
--T---TP------FSSIS------------K----------------------------
------------------------------------------------------------
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--------------------------MKYPSSN------------------------HSF
I---SCSA----------------------------------ARFS--T-----------
------LIPSWICKEAKDR-----------------------------------------
------------------------------------------------------------
------------------G-------------------------------------T---
---------QEEIL----L---------GSALARG-TRTMAQKMDCGAGLLGFQA-----
--------------------------------------------------------EASV
EDST-LLMQTLM-------EAIQ--IS-EAPPTNQA--TA--------------------
------------------------------------------AASGPNASPQSSQPPSA-
N------------------------------------------------EVAD-------
------IQALAAATKPKT------------------------------------------
-----------------------------AF---------------KAQ-----------
-------------NAT----------------TKGPNAAYDFSQALNAKEIP-STPPTVA
F-------------------KAPNAPS--KGPNAAYD-------FSQAATT---------
----SELTA-KPEMAFKAQNAT-TKVGPNA---------T-YNFSPSLNANEMVNTQPKT
------------------------------------------------------------
----------------------------------------------AFKAWNDTTKAPTA
-------------------------------ETQT-----------QNI-----------
----NQA---KMATSQ--------ADIEADPGPG---------ICESDGAAAQTSADGSQ
AQNLE--------------------S---------------------------------R
TIIRGKRTRKINNLNV---------EESSSGDQRRAPLAPGTWRSAPVPITT-QSPPGAP
PNVLWQTPLA----WQNPS----GWQNQPARQTP----P-ARQSPPARQTPPAWQNPVAW
QNPVIWPNPVIWQNPVIWPNPI-VWPGPVVWPNPLAWQNPPGWQTPPGWQTPPGWQGPPD
WQG---PPDWPLPPDW-PLPP-DWPLP-TDWPLPPDWIPTDWPVPPDWQNLRPSPNLRP-
-SPNSRASQNLGASQ-PRDVALL---QERANKLVK------YLMLKD-YTKVPI--KR--
------------------------------------------------------------
----SEM---LRDIIREYTDVYPEIIERACFVLEKKFGIQLKEIDKEEHLYI-LISTPE-
SLAGIL-GTTKDT-PKLG---LLL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPLLGDLRKLLTYEFVKQK-------
---------YLDYRRVPNSNP---P--EYEFLWGLRSYHETSKMKVLRFIAEVQKR---D
------PRDWTAQFMEAADEALDALDAAAA--EAEAR----AEARTRMGIGDEAV-----
------SGP--WSWDDIEFELLT-WDEEGDFGDPWS-RIPF----TFWARYHQNARSRFP
QTFAG---------------------P--IIGPGGTASA------NFAANFGAIGF----
--------FWVE------------------------------------------------
------------------------------------------------------------
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--------------------------------------MPPEQ-----------------
-----------------RSQ-HYKTE-E----------------GLEA----QGE-ALG-
-------------LVGAQAPATEE------------------------------------
-----------------------------------------------------------Q
E-T---------------------------------------------------------
------------------------------------------------------------
----ASFSSILV----EVT--RGR------------------------------------
---------SS--------------------------------------PE---------
--SSGAST---LPTTIS-Y--TLWSQSDE----------------DSSN--QEEEGP---
------------S------AFPDL---------------ESSFQAALSRKVAELV-----
-------HFLLLKYRAREPVT-KAEML--ESVMRNCQ-----YFFPVIFSKASDS-----
----LQLVFGIE---------LME-VDLIG---------HLYI-----------------
-------F----------------------------------VTCLGL-SYD----GLLG
---DN-QIMPKTGPL-------IIVLAIIAKEGDC------APEE---KIWEELSVL---
-----EVF-EGR----QHGIFADPRKLLTQNFVRE------NYLEYQQV-PSSDPACYEF
----LWGPRALIETS--YVKVLYHMLKISGGPHF----S-YSLLHEW---ALREGEE---
------------------------------------------------------------
------------------------------------------------------------
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--------------------------------------MHRA-P----------------
-----------------KRR-RYTIE-E----------------GLQS----QSE-AQE-
-------------RARAEVPEAEE------------------------------------
-----------------------------------------------------------E
D-TA-----------------------ASSSSSPISSI----------------------
------------------------------------------------------------
---------------------IKV--LSA---------------------AAG-------
----------G--------------------------------------SSPL---QSP-
---ERVCV---SPSVAI-V--TPSIESHQ----------------G-SSS-QKEEDP---
------------S------TLQALS------------DTGPLLIDAIYHKVSNLV-----
-------NFLLLKYRTKEPVT-KGEML--SSVIKEYQ-----DHFPKIFSQTSEC-----
----MQLVFGID---------VKE-VDPSN---------HSYV-----------------
-------L----------------------------------VNTLGL-TYN----EMLS
---DE-QSIPKAGLL-------IHILGVIFMDGNR------SSEE---HIWEVLRIM---
-----GVY-DGK----EHFIYGEPRELITKVWVQE------QYLEYRQV-PNSDPAQYEF
----LWGPRAHAETS--KMKLLEILANINDTTPD----A-FPVCYEE---ALRDEEMRSQ
------------------------------------------------------------
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--------------------------------------MPRGQK---SKLRAREKR-RQA
-QK-----DPQNL-----------------------------------------------
-VD-------------AQRSE---------------------------------------
------------------------------------------------------------
--YS-------------------------PSSSA-----H---------------SNDIP
QS-S-L------------------------TGTLS-------N-------PQGPKT---V
T--FPTTTAA-A------------------------------------------------
------------------------------------------------------------
-----------------AP----ATRSNEN----------------------T-ARP---
-----------------------------GS-TQSPSAMENFPNGPVDEKVVMLV-----
-------HYLLYKYQMKEPIS-KAEML--KNIIQVYR-----NQFHEILRKASDH-----
----LELIFGLD---------LKE-VDPNK---------HIYV-----------------
-------L----------------------------------INKLES-NCD----VSLS
----DEIRVPKTGLL-------MTILGVIFTNGNC------ATEE---KIWEVLNMM---
-----GLY-DGS----VHFVYGDPRKLITKDLVKE------KYLEYRQV-PHSDPPRYEF
----LWGPRAHAETS--KMKVLEFLAKIHSTVPS----A-FVSEHEE---ALRDEEERAQ
AR-IAARARVS-ER----------------------------------------------
----------------------------------------------------------AN
--------------------ARS--T-----------------------AMPG-STSNP-
------------------------------------------------------------
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---------------------CLDKVPPHPLLSDHRREVAQQSL----------------
-----------------TPP-AYSQM-REFSGWVSWLQPVEHSHFLFQ----VLR-GHS-
-------------TQEDRVLESMK------------------------------------
-----------------------------------------------------------E
T-----------------------------------------------------------
------------------------------------------------------------
---CLPSSHPVM----LGN--PQAA---S---------------------AAG-------
----------V--------------------------------------VNTP-------
QGPQT----------------ISLSKSDE----------------SSSSQ-EEEDSS---
------------S------SSQSPS------------DTENVPRDPLDEKAALLV-----
-------NFLLLKYQMKEPIT-KADML--NAVIGEYE-----DHFPEIILKASER-----
----MEMIFGLD---------LKE-VDPIS---------HKYA-----------------
-------L----------------------------------LIKLGL-TYD----GMLS
---GE-DGMPKTGIL-------ILILGVIFMKGNR------ATEE---EVWEVLNVT---
-----GIY-SGQ----KHFIFGNPTKLITKELVQE------KYLKYQQV-PNSDPAQYEF
----LWGPRAYAETT--KMKVLEFVAKVHGTDPS----S-FPSQYEE---ALKDEEEKAQ
A-----------------------------------------------------------
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-------------------------------------MMPRGR-----------------
-----------------KHR-LCKFE-G----------------GLQA----QGE-DAH-
-------------LPAYGE-----------------------------------------
------------------------------------------------------------
--------------------------------------EEA-------------------
TTAG-C---------------------------------------S----------PSA-
----------LI----QGT--HKE------------------------------------
---------EP--------------------------------------AAGV---PSPP
ENPHGA---S-SSTAKS-S--SAYSQSDE----------------SCTWQ-EEEG-R---
------------S------TWQYLE------------DTESKLRGALAEKMAELV-----
-------RLLLLRYLSREPIT-VEGML--SCVTENYE-----DYFPGIFCKAFEC-----
----IHLIFGIE---------MKQ-ADPTG---------HLYV-----------------
-------L----------------------------------VPALGL-TCH----DV--
LG-GD-QCIPKTGLL-------IAILGIVFIGGGR------VHEG---QIWEALSVM---
-----GLF-VGV----DHCIYGEPRQLVTKDWVQA------GYLEYRRQASKSSSAHYEF
----LWGPRAHAETS--TMRVLQYLAKCSRNDPR----F-HPAVKGK---AVRDEEGGMP
ATGAGGASGSE-------------------------------------------------
------------------------------------------------------------
-----------------------GG------RQG--------------------------
------------------------------------------------------------
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--------------------------------------MPRGQN---SKHRAREKR-RQT
-QT-----ETQGL-----------------------------------------------
-HD--------------QATTSGG------------------------------------
-----------------------------------------------------------E
-ETT-------------------------SSSLP-----D---------------SESAP
SSSS-A-------------------------AGT----------------PKGPQG---A
H--GTTSAAAGAIRKRSGGGGA--------------------------------------
------------------------------------------------------------
------------------A----RSRSGVGA---------------EG-Q-VQEGE----
-----------------------------NS-SQASAAAVSSHTDILTRKAELLV-----
-------PYMLYKYKMRELIK-RSEIL--KEINRRYK-----EQYPEILRRASEH-----
----MEMVFGLV---------LKE-VRPNG---------HCYI-----------------
-------L----------------------------------VSNLDL-SDS----ESMR
----SDLGLPKNGLL-------MPLLGVIYLNGNH------APEE---KIWKFLNML---
-----GIY-DGR----SHFIFGEPRKLITEDLVRD------EYLEYRQV-PGSDPPRYEF
----LWGPKALTETS--KMKVLQFLAKVKDSVHP----A-FLLQYEE---AWREEVETTG
ARSEA-RA-------------G---TSASTRPG---------------------------
-----------------------TAA----------------------------------
-S--------------------AAAGPSALARP-------GTA-------ASAAACSSAS
TRP-----------------G-TA------------------------------------
---------------ASTSAG-PSALATARPRATSSRS----------------------
------------------SRP---------------------------------------
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------M---LKDVIQEYDEYFPEVIEQASYTVEKMKGLNLKETYKQSSLYI-LISTQES
SSG-IL-GMTKDT-PKLG---LLM----------VILSV----------IF--------M
-NGNK----A-S--EAVIWEVLRKLGCA-LVMVRLSLFGEVRRLITDEFVKQK-------
---------YLEYKRVPNSRP---P--EYEFFWGLRSYHETSKMKVLKFACKVQKK---D
------RKEWAAQYQKAVEMEVQAAAVAAA--EAEAR----AEARAQMGIGEEAV-----
------AGP--WNWDDMDIDCLT-REELGDDAQSWN-RFSF----EIETRAQENAEASTN
IDFSRGAS-RATFSDSASISFSGAPSP--GGGFGG-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------RAGISFGGTPRTSASFSSIASICFSGIPSTSTSFSG------------
----------------------------------------------------------AA
SISFSGAASTSSSFNSEACISFDGTPCTSAGFGGGVSSSFSVPLS--SSSSFSGGASSGF
GG------------------TL-STTAGFSGTLITSSSFGSIPRTSTVFSGALSTSAGFG
GTLSTSVCFGGSPSSGASFGGTLNTSICFGSSPSTTTGFDG----MLSTSVSFGGSSSTS
TDFGGTVSTSISFGGSPSTG-ASFGGAFSTSVGFGGALNTSASFNS--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------AVSTSASFSSAPSTISGFGSVFSTS
ADFSGALSTTTDFG--------------------IAP--------------------STT
NGFGGVPSTSLSFGSVSNTNLCFGGPPSTSTCFSGATSASFGDGSSTTAGFIFGNGLSTS
AGFSGGLSTSAVFGSGLG------------------------------------------
----------------------------TSAIFGNGLSTSAGFGGGLISSNGFGDGLGTN
AGFNSTLGTSAGFSGGLSISDGFRAGPNNIFSGGPSTIIGLGSGSNTSTGFTGEPCTSTS
FSGGPSSIIGFSSGPSTGAGFS----------SGPR------------------------
------------------------------------------------------------
----------------------NGAGFGGGATSLGACSFSYG

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----------------GAS----STRAAGGA---------------EG-Q-DEGGP----
-----------------------------SS-SAAPAPTERSQRDPVTRRVSMLL-----
-------QFLLYKYKMKEPIT-KAEMM--KIINKRHK-----EHFPDILRRASVH-----
----LEVVFGLE---------LKE-VDSKG---------ESYA-----------------
-------L----------------------------------VSQLEI-SKE----ENFI
----GSRGFPKNGLL-------MPLLGMIYRNGDR------ATEE---EMWAFLNVL---
-----GIY-DGK----WHFMFGEPRKLITKDLVQE------KYLEYRQV-PNSDPPHYEF
----LWGPSAHAETS--KMKVLEFLDKEYDPAPS----A-FPLHYEE---ALRDEERRAP
ARAD-PTARAS-------------------------------------------------
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-----PLPVP----------------------------------------LSA-------
----------P-----------QAVH--CPPIIWQAPKGQPPAPQE--------------
------------------------------------------------------------
------------------------------------------------------------
---------MPTSMEFQEVQQ-AQASL--AWQAPKAQ-----GQFWQSLTTQEAQRQ---
----GPPLVQLE-------QPFQGAPASQKALQIQL-PTQQAQLS--GSQAELPSMQLQP
SWQGPPAALQGQPGAPLAGANFPMGSAKSLMTP-SGESRASSIDRRTSS-KD----RRTS
SK--ERKAPPKDRM----------IFGGTFCAPRA----MPPAGAHLPTPWKNLPATSET
FNATARVF-PST----SQFQPASSNAFKGPSAISE----APRSLPFTL---QDTFACIEA
LPAIPWVPQPNANSSKASKAGPSILM-ATAAAPQ----V-MAIT-QE---ASKTSAEPPR
RS-----------------------GKA--------------------------------
--TRK-----KKHLNTEEGDSSGKMLN-------------------------------MC
--H-WQAP----RRWENLD--LNDW--EVQTPIQ-F--LCDWEGPSTSRILSGWEGLSTS
-QI---------------LSG---WEGPSTSWALSAWEGPSTSR-A--------------
---------LGFW---------------ENPVSPPSLIISELP-------------T---
LAQGFGATQYDPKLE-TQPLSPL---DERANALVQ------FLLVKD-QAKVPI--KR--
------------------------------------------------------------
----SEM---VKFIIREYKDECLEIISRASHKLECVFGYQLKEIDPQNHSYI-LINKG--
RKGDTG-TSSLDR-PKIG---LLM----------VVLSL----------IF--------M
-KGNC----V-R--EDLIFTFLCKLGLN--IRETHGLFGNTKKLITEVFVREK-------
---------YLEYRRIPFTEP---E--EHEFLWGPRAFLETSKMIVLKFLARLYKK---D
------PRCWPYQYYEALAECESEDLDEDE-SGP----DDKT-------DDP--------
---TSSPPPH--------------------------------------------------
------------------------------------------------------------
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-----------RQRG-----------------------------------------PGCP
SLSIPC---ANTP---C-L-LS-------L-----TTVMPRGQK---SKLRSRAKR-QQA
-RD-----ETQGL-----------------------------------------------
-RG-------------AQATAEEE------------------------------------
-----------------------------------------------------------V
-GS--------------------------PCSSP-----L---------------DEGAL
PSSP-A-------------------------AGI----------------SQVSQR---A
P--PSSSLGA-G------------------------------------------------
------------------------------------------------------------
-----------------DS----CKSSEAGA---------------QE-R-----MP---
-----------------------------GS-SQAAASPESSRRDPLTRKASLLV-----
-------QYLLEKYKTKEPIT-QADML--KVVNKKYK-----EYFPEILRRTSER-----
----VELVFGLE---------LKE-VDPNS---------HSYV-----------------
-------L----------------------------------ISKLGL-SSE---GSL-S
----GSRGLPKTGLL-------MTLLGVIFMKGNR------ATEA---EIWEFLNVL---
-----GIY-AGR----RHLIFGEPRKLITKDLVQE------KYLEYRQV-PGSDPPSFEF
----LWGPRAHAETS--KMKVLEVLAKINDTNPN----A-FPNLYEE---ALKDEEEKAG
EK-AVGRVGAP-TR----------------------------------------------
----------------------------------------------------------PR
--------------------AVS--K-----------------------VLPH-RPSHI-
------------------------------------------------------------
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----MAPKRCSK-----------WPDPSQEE---------------GLAQ-E-EEE----
----------------EEEEEDFALTQ--RS-SQVQRNLQRLSGAQVDQKVSELV-----
-------QFLLVKDQKKIPIK-RADIL--KNIIKDYK-----DVYPEIINRAGRT-----
----LQQVFGLR---------LVE-IDTKH---------HVYI-----------------
-------L----------------------------------VSDLVRLEGE-----NLK
----QDHLTARLGLL-------TVILSFIYMRGNS------AKES---DVWDMLKRL---
-----GVE-PRK----PHKLFGDVKKLVTVEFVQQ------KYLEYNRL-PSTDPAEFEL
----QWGPRAAKETS--RMQILQFVAKIQSKDPK----T-WSAQYSE---AAAEVLSCSS
------SPP-GDVG--------GDSQ----------------------------------
------------------------------------------------------------
GPR--RRK------PSVSSSSP----HGAL------------------------------
------------------------------------------------------------
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------------------------------------------

------------------------------------------------------------
------------------LSL--VSQNSRR--LSSAK---ATA-----------------
----------HNSSSWGEMQAPNAPGVPAAMAGPDVPEGT--------------------
-------------------------------------SMPST------------------
---------------PGEGPST---------AVPPAAT---KGSSASGAPTV-SEG-PNI
ALSIAA---------------S-EL----PNSPLPPTAS---------------------
-----EGASASEHPSVTEGLN------ISEF-----------------------------
----------------------------PLSNESPSTSVPPTS--------GEGQSTSVL
LTACEGLSIS-------------------VPPTSGEELRTL-------VP--AAVSEGQG
LNAESRSGEGPS--------IS-----------------------------------VLP
T------VSKGQSTSVPPTPREGPSTSVLPTAS---------------ERPSTS------
------------------------------------------------------------
------------------------------------------VLPLSNERQSIFI-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------SSLALT------------------------------------
-----------------------------------------------------------A
FEEP------------------------VASLPP-----P---------------SGNSS
SM-SVLH--AS------WDGPS-TSRMPNAAESLGR--------SGM---PT--------
-----------------------------------------------------A------
---PGNPGALWSSGA-----SGSQNSSNCLF-----------------------------
-----------------------ASANSEGP---------------K-------------
-------GAEGPMEFQVLRDHKNSNSITIMGLGTAQVALTLKPQDPMEENVAELL-----
-------QFLLVKDQSKYPIR-ESEMQ--LHIAKEYS-----HQFPEILRRAAAH-----
----LECIFRFE---------LKE-LDAEE---------HTYI-----------------
-------L----------------------------------LNKLGPVPFE-----GLE
----DSPNGPKMGLL-------MMILGEIFLNGNQ------AKEA---EIWEMLWRM---
-----GVQ-RER----RLSIFGNPKRLLSVEFVWQ------RYLDYRPI-TDCTPVEYEF
----FWGPRSHLETT--KMKILKFMAKIYNKDPM----D-WPEQYSE---ALEEDAIRDA
ADD---------------------------------------------------------
------------------------------------------------------------
----WQAVPHFRRPFFEE----------IPAE------------------LLS-PD----
-SD---------------------------------------------------------
---------VSGY-------------------------P---------------------
---------SKYPPH-SWPESRM---ESKARKLVQ------LFLLMD-STKLPI--PK--
------------------------------------------------------------
----KGI---LYYIGRECSKVFPDLLNRAARTLNQVYGTELVVLDPRNHSYT-LYNRREM
EDAEEI-VDSPNR-PGNN---FLM----------QVLSF----------IF--------I
-MGNH----A-R--ESAVWAFLRGLGVQ--TGRKHVI--------TCRYLSQR-------
---------YIDSLRVPDSDP---V--QYEFVWGPRARLETSKMKALRYVARIHRK---D
------PQDWPEQYREAMEDEANRVDEERR-QI----------LIQNVR-----------
------------------------------------------------------------
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--------------------------------------MPRGQK---SKLRAREKR-QET
-HG-----QPQGL-----------------------------------------------
-TG-------------PQATAEKQ------------------------------------
-----------------------------------------------------------E
-ESH-----------------------SSSSSSH-----D---------------CLGTR
RRSS----------------------------DAS-------V-------PQESQG---V
S--PTGSPDAVVSCSKSDVAA----KGQDEKS------------ASTSLEASIPQESR-G
ASPTGSPDAGVSC---------SKS--------DVAVKGQDEKSLSTSPDASI-----SQ
ESQGASPTG---FPDAGVS----GSKYDVAA---------------KGQ---DEESV---
-----------------------------RA-SQKAIIFKRLSRDPLKRKACALV-----
-------QLLQEKFEKKESIL-KADML--KRVGKRYK-----HYFPEILNRTSER-----
----LAVAFGVE---------LKE-MDSSG---------ESYT-----------------
-------L----------------------------------VSKLGL-SSE----GILN
----DAKGLQKSGLL-------MSVLSVIFMKGNR------ATEE---EVWEFLSYL---
-----GIY-AGM----THPIYGDPQKLITEDLVQD------KYVVYRQV-CNSDPPHYEF
----LWGPRAHAETT--KMRVLHVLAKSNNTSPG----L-HPHLYED---ALMDEVERAL
RLRA--------------------------------------------------------
------------------------------------------------------------
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--------------------------------------------------MLQKPR---G
R--------------------------------------------------GRPST----
-------QTD----------------------------RERESEDA--------------
----------GEE----------APSTSRGT---------------GGSS-Q--------
------------------GSC---------S-SL------QRTQKQLDLKVADLV-----
-------QFLLIKDQKKIPIK-RADIL--KHVMGDYR-----DVYPHMLNLAAER-----
----LQYVFGYK---------LVE-LEPKS---------HTYI-----------------
-------L----------------------------------INMLEPVEED----AEVR
----GDQGTPTTGLL-------MIVLGLIFMKGNT------ITET---EVWDFLRRL---
-----GVY-PTK----KHLIFGDPKKLITEDFVRQ------RYLEYRRI-PHTDPVDYEL
----QWGPRTNLETS--KMKVLKFVAKVHNQDPK----D-WPTQYCE---ALADEENRAR
PAAS-APTTPLELL--------SSYYLLLFSFM---------------------------
----------------------GGREK-------------------------------E-
-------S------F---------------------------------------------
------------------------------------------------------------
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--------------------------ME-------------------------------F
L---SHLE-----------------------G----------M-----------------
------DLIYWLKDDRKML---------------------------KR--PPSVV-----
-----------------------------------------------VFVK----QIRET
----------HILLRDRRG-------------------------------------SQG-
-R-----VIQNIILFL---------KGHCSALARG-TGAMAQKMDCGAGLLGFQA-----
--------------------------------------------------------EASV
EERT-LLMQNLM-------EAIQ--IS-EAPPTSQA--VA--------------------
------------------------------------------AVSGQNVSPQCSQPPAA-
N------------------------------------------------EMAD-------
------VQVSAAATRPKT------------------------------------------
-----------------------------AF---------------KAR-----------
-------------NAT----------------TKDPNDVNDFAKAHNAKELA-STRPKAA
F-------------------KLQNAIL--KGPNAAYD-------FSKAAAT---------
----GEMATSDCEIALFKAQDVTTKVGSYP---------N-SSFSGSPNANEMVANQPQT
------------------------------------------------------------
----------------------------------------------AFKAWNNTTKAPVA
-------------------------------ASQT-------Y--SHNV-----------
----NRA---RMATSQ--------TN------AS---------IFEPDGAAAQTSADGFL
AQNLE--------------------S---------------------------------R
T--RGKRARKINNLNV---------EEN-SSDQRRAPLAAGTWRSAPVPVTT-PNPPGAP
PNVLWQTPLA----WQNPS----GWQNQPGRQAP----P-TRQSPPARQALPSWQNPVAW
QNPVIWPSPIIWPGPVVWPHPI-VWPGPVIWPHPVAWQNPPGWHTPPGWQNTPGWRGPPN
WQG---PSDWPLPPNW-PLPP-ECPLP-TEWPLPPDWIPADWPVAPDRQNLRPSPNLRP-
-TPNSRASQNLGAPP-PRDAALL---QERANKLVK------YLMLKD-YTKVPI--RR--
------------------------------------------------------------
----SEM---LRDIIREYTDVYPEIIERASFVLEKKFGIQLKEIDKEEHLYI-LISTPE-
SLAGVL-GTTKDT-PKLG---LLL----------VVLGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPLLGDLRKLLTYEFVKQK-------
---------YLDYRRVPNSNP---P--EYEFLWGLRSYHETSKMKVLRFIAEVQKR---D
------PRDWTAQFMEAADEALDALDAASA--EAEAR----AEARTRMGIGDEAI-----
------SGP--WSWDDIEFELLT-WDEEGDVGDPSS-RIPF----TLWTRHHQNAHSRFP
QTPAG---------------------P--IIGPGVTPTA------NFAANFGAIGF----
--------FWVE------------------------------------------------
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--------------------------------------MPRGQK---SKARAREKR-RLV
-QD-----EAQEL-----------------------------------------------
-QD-------------AQAKAGEK------------------------------------
-----------------------------------------------------------G
-KSP-------------------------SCSNQ-----D---------------SGDAV
ASTS-T-------------------------AGF----------------PQKSKS---Q
G--EAP------------------------------------------------------
------------------------------------------------------------
----------TTTARKGGA----CRRSRKST---------------RG-P-REESTS---
------------------------------C-TRVPRFSENPQNDLLTRKTGMLM-----
-------QYLLCKYKMKQPAS-KGEML--KVINRRFK-----EQLPEILKKASER-----
----IQLVFGLE---------VKE-IKPNG---------GYYT-----------------
-------L----------------------------------VSKLDP-SVG----NALT
----TSLPFPQNGLL-------MPLLGVIFLNGNR------ASEA---EIWEFLNVL---
-----GIY-DGK----VHIIFGEPRKLITRDLVKE------KYLVYQKE-ANSDPPSFEF
----LWGPRAYAETT--KMKILEFLAEVNETVPQ----A-FPTHYEE---ALRDQEERAQ
AEAV-GSP----------------------------------------------------
-----------------------------------------------------------G
--------------------TSAKD------------------------------KA---
------------------------------------------------------------
------------E-----------------------------------------------
------------------AKVTL---V-DSSCKYQ------AE-SKV-TLVDSS--CK--
------------------------------------------------------------
----DQAESKVTLVDPSCKDNAKSK-------VTL---------GSS-RKY---KAKSKV
PLVDSS-CKDQAE-SKVT---LVDSCKDQAESKVTLVDSSCKDQAESKVTL--------V
-DSSC----KDQ--AESKVTLVDPSCKD--KAKSKVTLGSSHKYKAKSKVTLV-------
---------DSSCKDQAESK--------VTLVDSSCKDQAESKVTLVDPSCKDNAK---S
KVTLGSSRKYKAKSKVPLVDSSGKDKAV--------------------------------
------------------------------------------------------------
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--------------------------------------MPRR-K----------------
-----------------KNH-SCKSE-A----------------GLKA----PKG-AQG-
-------------AVGAPVPVTGK------------------------------------
-----------------------------------------------------------E
A-----------------------------------------------------------
------------------------------------------------------------
---AASSLSPSI----QGT--PEVV---S---------------------AAG-------
----------K--------------------------------------PRVR-------
KSSQKA-G---SSTMVK-A--TPSSKPEE----------------G-SSS-P-KQGP---
------------STPQAPSTSQAPP------------DPESSLSDALNQKMAELV-----
-------QFLSAKYVTKEPIT-EAEML--ESVLKEHK-----GHFPVIFRKACEC-----
----MEIVFGIE---------VKE-GDPIN---------RSYV-----------------
-------L----------------------------------VRTLDL-TYD----GLLS
---D-DLGMPKTGLL-------ILILGVIFVEGNR------ASEK---RIWEVLKKI---
-----GVR-AGR----KDFIYGEPRKLITKDFVQE------KYLEYRQV-PNSNPPRYEF
----LWGPRAHSETS--KMKVLQYFAKVSGTDPT----S-FPSWYEE---ALRDERERAE
ARVAATNDSGG-------------------------------------------------
------------------------------------------------------------
-----------------------KA--------S----------------ESS----SD-
------------------------------------------------------------
---------PLG---------------------SCSR-----------------------
------------------PK----------------------------------------
------------------------------------------------------------
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--------------------------------------MPRRQK---SKCCARVKR-HQT
-RG-----ETQSL-----------------------------------------------
-KA-------------AEEES---------------------------------------
------------------------------------------------------------
-P---------------------------SSPSS-----V---------------SQGAP
PSSP-A-------------------------AGT----------------RQRPQA---G
P--APSSPEA-G------------------------------------------------
------------------------------------------------------------
-----------------VS----RPGAEAGA---------------QS-Q-DE-NGA---
-----------------------------SA-SQAAPSTQSTRKDPLTRKASMLV-----
-------QFLLEKYKMKEPIM-QTALL--KIINKKYK-----EHFPEILRRASER-----
----MELIFGLE---------LKE-VNRSN---------HTYT-----------------
-------L----------------------------------VSKLSL-PSDGGHGGQ-S
----DERGLPRSGLL-------MTLLGVIFMKGNR------ATEE---EVWEFLNTL---
-----GVY-AGR----RHLIFGEPRRLITKDLVQQ------KYLKYRQV-PHSDPPHHEF
----LWGPRAHAETT--KMKVLEVLAKINDTVPS----A-FPNLYEE---ALKDEEERAG
VR-AEAKATAL-AE----------------------------------------------
----------------------------------------------------------AR
--------------------APS--R-----------------------AKSR-SSTHI-
------------------------------------------------------------
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--------------------------------------MLLGK-----------------
-----------------THQ-SCKAE-E----------------GRQA----QGD-APG-
-------------LMDVQTPTTEE------------------------------------
-----------------------------------------------------------Q
K-A---------------------------------------------------------
------------------------------------------------------------
----ASSSSTLI----VGT--LEE------------------------------------
---------VP--------------------------------------DSGS---LSPA
QSPQGASS---SQTVTD-N--TLWSQSNE----------------VSSS--NEEEGP---
------------S------TSPDPA------------HLESLFREALDEKVAELV-----
-------HFLLRKYQIKERVT-KAEML--ESVIKNYK-----NHFPEIFSKASEC-----
----MQVIYGID---------VKE-VDPAG---------HCYV-----------------
-------L----------------------------------VTCLGL-SYD----GLLG
---DD-QSTPKTGLL-------IIVLGMIVMEGIC------APEE---AIWEALSVM---
-----GLY-DGR----EHSVYWKLRKLLTQEWVQE------NYLEYRQA-PGSDPVRYEF
----LWGPRALAETS--YVKVLEHVVRVNARVRI----S-YPSLHEE---ALGEEKEGV-
------------------------------------------------------------
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------------------------------MPR---------------------------
----------------------GKKAK-------------------------------LH
--------------------TCEKHH-QAQHGTQD---LRGAQVTATTMEALS-SSSSP-
-GP-------------------GVD-AKG-KSSARSWNHLKCPQ-G-------------A
---------FAT-----------------------TTVPAGVS------PTRSSKRALGK
IGKKRNS SQSPVSNV-RSGKHSL---TRQTGL LVQ------FLLCMY-KKK-PF--KK--
------------------------------------------------------------
----ANI---LKIIDK----KYQKILKRASDSMEVVFGIDVKKDNTAKHSYV-LVSKMNL
PHNGIV-HRGRGF-SKTG---LLM----------NLLGV----------IF--------M
-KGNC----T-T--EEDILDFLGKMNIY--AGKRHFIFGEPKKLITQDLVQMK-------
---------YLEYQQVPGNDP---A--CYELLWGPRXHA---------------------
------------------------------------------------------------
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--------------------------------------MPRGQK---SKLQAREKR-HQA
-RC-----KSHDT-----------------------------------------------
-GG-------------AQATAAAA------------------------------------
-----------------------------------------------------------A
-AKE-------------------------SPPEE-----S---------------P--PE
----ES------------------------PPSPS-------L-------SEGPQE---T
P--STTTTSE-V------------------------------------------------
------------------------------------------------------------
-----------------IS----CTRSDEDS---------------NV-Q-DE-TKE---
-----------------------------SN-AEASPCSEKSCNDPLASNIKVLE-----
-------QFLLFKYKTKQPIL-KADML--KVVSWRYK-----DHFPEIFKKACEH-----
----IELVFAVD---------VQE-IDSTR---------QLYD-----------------
-------L----------------------------------VSKLKL-PNK----GRVR
----AGRGLPKGGLL-------MNILGMIFMKDNC------ATEE---DVWRYLSMM---
-----RIY-AGR----KHFVYGEPKKLITKDFVRL------KYLEYRQV-PDSDPACYEF
----LWGPRAHAETS--KMEVLKFLAKINETEPS----A-FPSQYEE---ALRDEETRAQ
AQ-TVGVAKRG-AT----------------------------------------------
----------------------------------------------------------AK
--------------------ACALCK-----------------------AMR---S----
------------------------------------------------------------
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-----------------------------------------------------------V
GMSP-V-------------------------PGA----------------MLQKAR---S
R--------------------------------------------------GRSSS----
-------QAD----------------------------RDGGR-----------------
--------GAAEE----------TPSTSRGP---------------GGSQ-E--------
------------------AL--------------SAPSVGPRTQKQLELKVAELV-----
-------QFLLVKDQKKIPIK-RTDIA--KHVLGDYK-----DVLPDLLRLAGER-----
----LQYVFGYK---------LVE-LEPRS---------NAYI-----------------
-------L----------------------------------VNTLEPVEED----AAVR
----GDQGTPTTGLL-------MIVLGLIFMKGNA------VKET---EVWDFLRRL---
-----GVH-PTK----RHVVFGDPKKLLTEDFVRQ------RY-EYRRI-PHTDPVDYEV
----PVGP----------------------------------------------------
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--------------------------------------MSHR-Q----------------
-----------------K------HD-Q----------------GL-----------EG-
-------------QLGEEVPAAK-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------EV---S---------------------AAE-------
------------------------------------------------------------
-ESQDTSS---SSASVQ-A--TAPSKASK----------------V-SGD-QAAGGQ---
------------S------TSKAYL------------YSKFLLNSNLQKKVTDLV-----
-------KFLSFKYITNEPVT-EAEIQ--KHVVKEYK-----GYYALIFRHACEC-----
----MEVVFGIE---------VKE-VDSLN---------HTYK-----------------
-------L----------------------------------LKILDL-TYD----GRIS
---N-EEGIPKTGLL-------VLILGVIFMEGNR------ASEK---KIWDVLSVV---
-----GMY-PDR----HDFICGDPRKFITEDLVLE------NYLVYQPI-PNSDPTSYEF
----LWGPRAQAETS--KMKVLQFFSKVAGSSPT----S-FTALYKE---ALKDEEERAR
ALLASTAISTA-------------------------------------------------
------------------------------------------------------------
-----------------------AD--------N----------------LGS----GE-
------------------------------------------------------------
---------KPS---------------------SVSH-----------------------
------------------PE----------------------------------------
------------------------------------------------------------
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---------------------------------------MAQKMDCGAGLLGFQSPDA--
--CRAVCHPLPQPPASTLPLSAFPT-LCDPPYSQLRDPPPVLSCYCTPLRASLAPAEASV
EDSA-LLMQTLM-------EAIQ--IS-EAPPTNQA--TA--------------------
------------------------------------------A-----ASPQSSQPPTA-
N------------------------------------------------EMAD-------
------IQVSAAAARPKS------------------------------------------
-----------------------------AF---------------KVQ-----------
-------------NAT----------------TKGPNGVYDFSQAHNAKDVP-NTQPKAA
L-------------------KSQNATP--KGPNAAYD-------FSQAATT---------
----GELAANKSEMAFKAQNAT-TKVGPNA---------T-YNFSQSLNANDLANSRPKT
------------------------------------------------------------
----------------------------------------------PFKAWNDTTKSPTA
-------------------------------DTQT-----------QNV-----------
----NQA---KMATSQ--------ADIETD--PG---------ISESDGATAQTSADGSQ
AQNLE--------------------S---------------------------------R
TIIRGKRTRKINNLNV---------EENSSGDQRRAPLAAGTWRSAPVPVTT-QNPPGAP
PNVLWQTPLA----WQNPS----GWQNQTARQTP----P-ARQSPPARQTPPAWQNPVAW
QNPVIWPNPVIWQNPVIWPNPI-VWPGPVVWPNPLAWQNPPGWQTPPGWQTPPGWQGPPD
WQG---PPDWPLPPDW-PLPP-DWPLP-TDWPLPPDWIPADWPIPPDWQNLRPSPNLRP-
-SPNSRASQNPGAAQ-PRDVALL---QERANKLVK------YLMLKD-YTKVPI--KR--
------------------------------------------------------------
----SEM---LRDIIREYTDVYPEIIERACFVLEKKFGIQLKEIDKEEHLYI-LISTPE-
SLAGIL-GTTKDT-PKLG---LLL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPLLGDLRKLLTYEFVKQK-------
---------YLDYRRVPNSNP---P--EYEFLWGLRSYHETSKMKVLRFIAEVQKR---D
------PRDWTAQFMEAADEALDALDAAAA--EAEAR----AEARTRMGIGDEAV-----
------SGP--WSWDDIEFELLT-WDEEGDFGDPWS-RIPF----TFWARYHQNARSRFP
QTFAG---------------------P--IIGPGGTASA------NFAANFGAIGF----
--------FWVE------------------------------------------------
------------------------------------------------------------
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---------------------------------------MSDT-----------------
---------------SE-RAT----------------------------GPTRFQTEASE
KDSG-LKIQTLL-------TVTQ--NLEVSETLKTS------------------KA----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------PEVSEAMKVS-------NAAGVS---------------KAT-----------
-------------EV---------------------------SKAPEAQKAA-ATQASPT
-TKLTDTQVLAV----EK--KSPAADT--KMQSADPQ-------PVTMPAT---------
----ETKK-----VSC--------------------------------------------
------------------------------------------------------------
--------------------------------------------------------VA--
-------------------------------DTKV-------------------------
----V-T--KALDTEA--------PASQALADEP---------KP--EGAAAQVQENQDT
RPKVK--------------------A---------------------------------K
KARKVKHLNGEDDGN---------------SDQSQASETAAGRRVSKALMASMARRASRG
PIAFWARRAS----RTRLA----A------------------------------------
------------------------------------WARRALL----SLRSPKARRGKAR
RRA---------------------------------------------------------
-AKLQS-SQEPEAPP-PRDVALL---QGRANDLVK------YLLVKD-QTKIPI--KR--
------------------------------------------------------------
----SDM---LKDIIKEYTDVYPEIIERAGYSLEKVFGIQLKEIDKNDHLYI-LLSTLEP
TDAGIL-GTTKDS-PKLG---LLM----------VLLSI----------IF--------M
-NGNR----S-S--EAVIWEVLRKLGLR--PGIHHSLFGDVKKLITDEFVKQK-------
---------YLDYARVPNSNP---P--EYEFFWGLRSYYETSKMKVLKFACKVQKK---D
------PKEWAAQYREAMEADMKAAAEAAA--EAKAR----AEIRARMGIGLGSE-----
----NAAGP--CNWD-------------EADIGPWA-KARIQAGAEAKAKGQESG--GAS
SG------------------ASASTSA--SGGFSASASLTATLTFGLFAGLSGAGASTSG
SSGACG-FSYK-------------------------------------------------
------------------------------------------------------------
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--------------------------------------MPRGKK---SKLRAREKR-HHQ
AQS-----EDQGH-----------------------------------------------
-RI-------------AHTTTAGE------------------------------------
-----------------------------------------------------------E
-ESP-------------------------SSPSL-----T---------------LEGSP
PSSP-A-------------------------AGT----------------PQQSQR---G
L--AS-NS-AAT------------------------------------------------
------------------------------------------------------------
-----------------IS----CESSGEGA---------------KS-Q-RK-ERP---
-----------------------------SS-SQAPPSSESSREDLLANKVSMLV-----
-------KALLYKYEMKEPIT-KEEML--KVINKRYK-----AHFPEILQRASER-----
----LELTFGLD---------LKE-VDPSR---------HCYI-----------------
-------L----------------------------------VSQLDL-HNE---ESRSD
----GGMVLPKNGLL-------MPLLGMIFLNGNH------ATEE---EVWEFLNMM---
-----GVY-AER----RHFIFGEPRKLITIDLVQQ------KFLEYRQV-PHSDPPRYEF
----LWGPKAYAETS--KMKVLEFWAKINNILPT----S-FQTQYKE---ALRDEEERAR
VR-AAARAHSR-AMTS--------------------------------------------
------------------------------------------------------------
--------------------SSC--Q-----------------------QR---------
------------------------------------------------------------
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----------MSPHP------FPNDG-E----------------DSQN----PDV-IED-
-------------S----------------------------------------------
-------------------------------------------------ANAQIP--LDE
EASS-------------------------MSS-SYAYIFPSSPS----------------
------------------------------------------------------------
------L-ASLN----LSG--SDEEEVL----------------SAGMSSLTWSTP---S
S----PP-------------------------------------------------QSPP
QNPMSSYS--------S-S--VSWSSVSG----------------ESSSQ-KEED-T---
------------S------TCQGL------------SDSESLFTNTLDEKVAEVV-----
-------QFLLLKYEAKEPIT-EAEML--MIAL-SYH-----DYFPIILEKAHEF-----
----MELLFGLA---------LIE-VDPD----------HLYA-----------------
-------F----------------------------------ADTVDP-TNK----GS--
-S-DD-QGMPKNSLL-------ILILSIIFIKDGC------ASEE---AIWEVLNAI---
-----GVY-AGR----EHFVYGEPGELLTKVWVQE------QYLEYQEV-PNSSPPCYDF
----LWGPRAHSESS--KRKVLEFLAKLNDTVPN----S-FPSWYKD---ALKNVGERAQ
AIISTKDDA-T-------------------------------------------------
------------------------------------------------------------
-----------------------DK------ASE----------------SLS--D----
------------------------------------------------------------
---------IQH---------------------PLLF-----------------------
------------------------------------------------------------
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--------------------------------------MPRCQK---NKLHTREKH-HQA
-QG-----ETQGL-----------------------------------------------
-RG-------------AKE-----------------------------------------
-----------------------------------------------------------K
-ALP-------------------------SSPSA-----P---------------LQAVS
QSKP-A------------------------RMSCR-------I-------RRCSHK---A
P--ST--ITK-S------------------------------------------------
------------------------------------------------------------
-----------------AS----HTKLSKGV---------------NC-K-TE-NKQ---
-----------------------------SS-SKTSPSKAKSQRDPLTEMSNILV-----
-------QFLMQMYKKKKPIK-KADML--KIIHKKYK-----NSFSEILSRASFN-----
----IEVVFGVD---------LKE-VDGMK---------HLYN-----------------
-------L----------------------------------VNKMDL-PNN----GRVH
----RGRGFPKTGLL-------MTILGVIFMKGNC------ATEQ---KIWEFLNKM---
-----KIY-AGK----RHFIFGEPKKLITQDFVKL------KYLEYRQV-PGSDPPCYEF
----LWGPRAYAETS--KMKVLQFFAKINQTIPS----A-FTSWYEE---ALQDEKERAQ
AP-IPLRADTN-AM----------------------------------------------
----------------------------------------------------------A-
------------------------------------------------------------
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--------------------------------------MPRGQK---SKLRAREKR-RKA
-RD-----EIRSA-----------------------------------------------
--Q-------------ATVE--EK------------------------------------
-----------------------------------------------------------K
-ESA-------------------------PPTF------A---------------LRTAP
PRPP-T-------------------------VSG----------------LQTLQK---A
P--PPITA--AA------------------------------------------------
------------------------------------------------------------
----------------DVS----CTRCNKVI---------------ES-Q-GQ-ENA---
-----------------------------SF-SQASTSTETSRKDPLTRKAGVLM-----
-------HFLMEKYKLKKPFT-KAEML--KVVSKRYR-----DQFPEILKLASER-----
----VELVFGLD---------LKE-LNPGS---------QSYT-----------------
-------L----------------------------------ISKLDL-NDD---GSL-K
----SDWEFPKNGLL-------MPLLGVIFLNGNC------ASEE---EIWEFLNIL---
-----GVY-DGR----KHLIFGEPRKLITQDLVHD------KYLVYQQV-PNSDPPSYEF
----LWGPRAHAETS--KMKVLEFLAKINDTVPS----A-FPFHYEE---ALRDEEDRAR
AR-VASR--S--GNFA--------------------------------------------
--------------------------K-------------------------------SR
--------------------GRA--R-----------------------ATGG-SSSHP-
------------------------------------------------------------
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--------------------------------------MPRA-P----------------
-----------------KRQ-RCMPE-E----------------ELQS----QSE-TQG-
-------------LQGAQAPLAVE------------------------------------
-----------------------------------------------------------E
Y-AS-----------------------SSTS-TSSSFPSSFPSS----------------
-----------------------------------------------------------S
S-SSSSSCYPLI----PST--PEE--VSA---------------------DEE-------
----------T--------------------------------------PNPP---QNA-
---QIACS---SPSVVA-S--LPLDQSDE----------------G-SSG-QKEESP---
------------S------TLQALP------------DNESLPRSEIDEKVTDLV-----
-------QFLLFKYQTKEPIT-KAEIL--ESVIKNYE-----DHFPLLFSEASEC-----
----MLLVFGID---------VKE-VDPTG---------HSFV-----------------
-------L----------------------------------VTSLGL-TYD----GMLS
---DV-QSMPKTGIL-------ILILSIIFIEDYC------IPEE---VIWEALNMM---
-----GLY-DGM----EHFIYGEPRKLLTQDWVQE------NYLEYRQV-PGSDPARYEF
----LWGPRAHAEIR--KMSLLKFLAKVNGSDPR----S-FPLWYEE---ALKDEEERAQ
ARIATTDDTTA-------------------------------------------------
------------------------------------------------------------
-----------------------MA--------S----------------ASS----SA-
------------------------------------------------------------
---------TGS---------------------FSYP-----------------------
-------------------E----------------------------------------
------------------------------------------------------------
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--------------------------------------MPLG-Q----------------
-----------------KSE-LWKLE-E----------------DP-------GE-AQG-
-------------LVNAQLSGAEE------------------------------------
------------------------------------------------------------
---S-----------------------S--------------------------------
------------------------------------------------------------
---PSSSCSALF----LIP--VDN--RSA---------------------AG--------
----------S--------------------------------------LSPP---QSL-
---QHACL---SPTAMA-S--TAGNQPYQ----------------G-SSS-SDEGGL---
------------S------TWGELE------------VTQPFLQEKLRMKVADLV-----
-------EFLLLKFRTKQPTS-QAEML--EIVSKDYH-----DYFPVILGQAFEC-----
----MQLVFGVD---------VKE-VDPSE---------HFYV-----------------
-------L----------------------------------VTVLGL-TCD----EMLS
---GE-QGPPKTGLL-------VVLLGVILLEGDR------APEE---VVWEALGVM---
-----GVY-AGE----EHIIYGEPRELLTNVWVQE------GYLEYRQV-PGSDPARYEF
----LWGPRAHAETS--RLQVLEYLLRVNRGLPV----SSWPHL----------------
------------------------------------------------------------
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----------------------LGQVSTMFSEDDFQST---EGAPSGPQI----------
---------QWSQDLPRVQVFRE----------QANQE---DRSPR-RTQRITRG-EV--
-----------------LWGPITQIFPTVWPADLTGVIMPLEQ-----------------
-----------------RSQ-HCKPE-E----------------GLQA----QED-NPG-
-------------LVGGAQALQAE------------------------------------
-----------------------------------------------------------E
Q-E---------------------------------------------------------
------------------------------------------------------------
---AASFSSTLN----VGT--LEE------------------------------------
---------VP--------------------------------------ATES---PSPP
QSPQGESS---SPTAMD-S--IFGSLSDE----------------GSSS--QEEEGP---
------------S------TSPDLI------------DPESFSQDILHDKIIDLV-----
-------HLLLCKYRVKGLIT-KAEML--GSVIKNYE-----DYFPEIFREASEC-----
----MQLLFGID---------VKE-VDPTS---------HSYV-----------------
-------L----------------------------------VTSLSL-SYD----GIQG
---DE-QSMPKSGLL-------IIVLGVIFMEGNC------VPEE---VMWEVLSIM---
-----GVY-AGR----EHFLFGEPKKLLTHDWVQE------KYLVYRQV-PGTDPACYEF
----LWGPRAHAETS--KMKVLEYIANANGRDPS----S-YPSLYED---ALREEEEGV-
------------------------------------------------------------
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------------------------------------------------------------
-----------------------------------------------------MSEQSKD
LSD---------------------------------------------------------
------------------------------------------------------------
--------PNF----------------------------A---------------AEAAA
NSEV--------------------------HGS-----------------PAVPVG---V
P--PPASPAET----------LAGPPSAPEGP------------V---------------
----AAPQAL--------------------------------------------------
------PPQ--------------EERLEDID---------PKIL-QQA-I-EE--GR---
----------------------AHQPQ--SPARQ--M-PPPPAPAQLVQKAHELM-----
-------WYVLVKDQKRMVLW-FPDMV--KDVMGSYK-----KWCRSILRRTSLI-----
----LARVFGLH---------LRL-TNLHT---------MEFA-----------------
-------L----------------------------------VKALSPEELD-----RVA
----LNNRMPMTGLL-------LMILSLIYVKGRG------AREG---AVWNVLRIL---
-----GLR-PWK----KHSTFGDVRKIITEEFVQQ------NYLKYQRV-PHIEPPEYEF
----FWGSRANREIT--KMQIMEFLARVFKKDPR----A-WPSRYRE---ALEQARALRL
ASLAA----------------------------------HFPRRSVSED-----------
------------------------------------------------------------
------------------------------------------------------------
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--------------------------------------MPRR-H----------------
-------------RQHHRIQ-RRRLE-E----------------GLRA----QRE-VQG-
-------------LVGAQAPGAEE------------------------------------
-----------------------------------------------------------E
---G-----------------------AAAF-----------------------------
------------------------------------------------------------
--------SS------------TEA---A---------------------AAA-------
----------P--------------------------------------PSPP---QS--
--PQGASS---SPTGLA-S--NPMCHSNE----------------G-SSN-QEEEGP---
------------S------TSQDLA------------DPASVMQDTLEEKMSDLI-----
-------HFLLLKYRIKELIT-KEEML--NTVIKDYQ-----DHFPEIFREASDC-----
----MQVVFGVD---------VKE-VDPTS---------QSYI-----------------
-------L----------------------------------VTSVGL-TYY----EELN
---DA-QRFPKAGLL-------IIILGLIYLEGDC------AQEE---VIWDALGAM---
-----GVH-AGM----EHYIYGEPRKLITQDWVQE------GNLEYRQL-PNSDPACNEF
----LWGPRAHAETS--KLKVLEYVAKVSGCDPR----S-FPFLYEE---ALRDEEEEA-
------------------------------------------------------------
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------------------------------------------------------------
--------------------------------------MPRGQK---SKLRAREKR-RET
-HG-----PPQGL-----------------------------------------------
-TG-------------PQVTAEKQ------------------------------------
-----------------------------------------------------------E
-ESR-----------------------SSSSSSA-----V---------------CRSAR
RRSS----------------------------DSS-------V-------PQESQG---A
S--PTGSPDTGVSCSKSDVAA----KGQDEKS------------PSTSRDASVSRESQGG
ASPTGSPDAGVSC---------SKS--------DMAAKGQDEKSPSTSPDASV-----PQ
ESQGASPTG---SPDADVS----GSKSDVAA---------------KGQ---EGESI---
-----------------------------SP-SERTVFFTTADRDPLNRKASKMV-----
-------QFLQEKFEKKESIL-KADML--RRVRRQYK-----PCFPEILKRTSER-----
----LAVVFGVE---------LKE-MDSSG---------ESYT-----------------
-------L----------------------------------VSKLGL-SSE----GSLS
----GDNALPKSGLL-------MSLLGLIFMKGNR------ATEE---EVWEFLGVL---
-----GIY-DGI----LHSIYGDTRKIITEDLVQD------KYVVYRQV-RNSDPPRYEF
----LWGPRAHAETT--KMKVLRVLAEINNTSPG----L-YPHLYED---ALIDEVERAL
RLRA--------------------------------------------------------
------------------------------------------------------------
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------------------------------------------

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------------------------------------------------------------
--------------------------------------MPRGQK---SKLRARERR-RQA
-RG-----DTHSV-----------------------------------------------
-EG-------------AQAAAAEE------------------------------------
-----------------------------------------------------------E
-GSP-------------------------SSSSP-----P---------------FGESP
SSSP-A-------------------------AGI----------------PQGPQS---I
P--PTTTAA-AG------------------------------------------------
------------------------------------------------------------
-----------------AS----GTRAAGGA---------------EG-Q-DE-GGP---
-----------------------------SS-SAAPAPTERSQRDPLTRKVSMLL-----
-------QFLLHKYKMKEPIT-KAEMM--KIINKRYK-----EHFPDILRRATEH-----
----MELVFGLD---------LKE-VDSKG---------QYYT-----------------
-------I----------------------------------VSKLEI-TKE---ENF-I
----GARGFPKNGLL-------MPLLGIIYRNGNR------ATEE---EMWEFLNVL---
-----GIY-DGK----RHFMFGEPRKLITKDLVQE------GYLEYRQV-PNSDPPRYEF
----LWGPRAHAEAN--KKKVLEFLAKIGATDSS----G-FQAVYE--------------
------------------------------------------------------------
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------------------------------MPR---------------------------
----------------------GQKNK-------------------------------H-
RKRLKNKKHNQEKGHPEKDESQDKGH-HKRDDSQD---HKEAAQDSAAIEEMP-PCSSS-
-SV-------------------PGK-ILE-TPPVSETNS------D------------VG
---------WPSC---I-------------PSPVTIC-SDDLD---------FDDEIYCQ
CGGNSLYSEYRTCQN-IPCKHCL---DMYVAFVEQ------YVLYKF-KMKQLI--VR--
------------------------------------------------------------
----KDL---INVIEPKYQYRFNEISKRAFENIETVFGVSVIEIDSTNHIYD-LVSNLKL
PNKGRV-CAGRGL-PKTG---LLM----------TILAM----------IF--------M
-KGNS----V-S--EEDIWKFLNFMQVY--PGRKHFIYREPRKLITQDFVRLK-------
---------YLEYGQIPNSDP---P--CYQFQWGPKAYAETTKMKVLEFMAKGSGV---E
------PSTFSVQYAEALKEENQKIKIRKW-YP---------ILA----QKHCLGHGH--
HHIHKVMTPQ--------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------MPR---------------------------
----------------------GQKSK-------------------------------SR
--------------------SRAKRQ-QARSELQG---LPAVHH--TAEEAAS-LSV---
----------------------DRRDGSN-FP---DGCTPQGMK-T-------------P
---------GSLS---A----------------AVSGIGSVLG---------VSNAVVVA
GKQSSDATQAATSIQ-HTLKDPI---MRKASVLIE------FLLDKF-KMKEAV--TR--
------------------------------------------------------------
----SEM---LAIVNKKFKEQFPEILRRTSARLELVFGLELKEIDPSTHSYL-LVGKLGL
STEGSL-SSNWGL-PRTG---LLM----------SILGV----------IF--------M
-KGNR----A-T--EQEVWQFLNGVGVY--AGKKHLIFGEPGEFI-KDLVQEN-------
---------YLEYHLIPGSDP---P--NYEFLWGPRAYAETTKMKVLEVLAKVNGT---V
------PSAFPNLYQLALRDQARGARRRPQ-GR--V-------------HSKPLSQ----
------------------------------------------------------------
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---------------------AYTSKG--------------------------EENL---
------------D----LRDFDSNQ------------QSESFLRSKIEEKVSNLV-----
-------EFLLFKYQTNAPTT-KEEML--MCVIQNYQ-----DHFPVILSEASEC-----
----MQLVFGID---------VKE-VDPTN---------HSYA-----------------
-------L----------------------------------VISLGL-TYD----GLLS
---D-VQGMPKTGLL-------ILILSVIFMSGNY------APEE---EIWDVLIGM---
-----GLS-LGE----RHYIYGKPEKLLTEDWVQE------GYLEWRQV-PNSDPARYEF
----LWGPRAHAEIS--KMSLLEFLAKINGSDPR----S-FPVWYEE---ALRDEAERAQ
ARIATVDT-TA-------------------------------------------------
------------------------------------------------------------
-----------------------MA--------S----------------ASS----IA-
------------------------------------------------------------
---------SI-------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
---------------------------------------MAQKMDCGAGLLGYQA-----
--------------------------------------------------------EASV
EDSA-LLMQTLM-------EAIQ--IS-EAPPTNQA--TA--------------------
------------------------------------------A-----ASPQSSQPPTA-
N------------------------------------------------EMAD-------
------IQVSAAAARPKS------------------------------------------
-----------------------------AF---------------KVQ-----------
-------------NAT----------------TKGPNGVYDFSQAHNAKDVP-NTQPKAA
L-------------------KSQNATP--KGPNAAYD-------FSQAATT---------
----GELAANKSEMAFKAQNAT-TKVGPNA---------T-YNFSQSLNANDLANSRPKT
------------------------------------------------------------
----------------------------------------------PFKAWNDTTKSPTA
-------------------------------DTQT-----------QNV-----------
----NQA---KMATSQ--------ADIETD--PG---------ISESDGATAQTSADGSQ
AQNLE--------------------S---------------------------------R
TIIRGKRTRKINNLNV---------EENSSGDQRRAPLAAGTWRSAPVPVTT-QNPPGAP
PNVLWQTPLA----WQNPS----GWQNQTARQTP----P-ARQSPPARQTPPAWQNPVAW
QNPVIWPNPVIWQNPVIWPNPI-VWPGPVVWPNPLAWQNPPGWQTPPGWQTPPGWQGPPD
WQG---PPDWPLPPDW-PLPP-DWPLP-TDWPLPPDWIPADWPIPPDWQNLRPSPNLRP-
-SPNSRASQNPGAAQ-PRDVALL---QERANKLVK------YLMLKD-YTKVPI--KR--
------------------------------------------------------------
----SEM---LRDIIREYTDVYPEIIERACFVLEKKFGIQLKEIDKEEHLYI-LISTPE-
SLAGIL-GTTKDT-PKLG---LLL----------VILGV----------IF--------M
-NGNR----A-S--EAVLWEALRKMGLR--PGVRHPLLGDLRKLLTYEFVKQK-------
---------YLDYRRVPNSNP---P--EYEFLWGLRSYHETSKMKVLRFIAEVQKR---D
------PRDWTAQFMEAADEALDALDAAAA--EAEAR----AEARTRMGIGDEAV-----
------SGP--WSWDDIEFELLT-WDEEGDFGDPWS-RIPF----TFWARYHQNARSRFP
QTFAG---------------------P--IIGPGGTASA------NFAANFGAIGF----
--------FWVE------------------------------------------------
------------------------------------------------------------
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------------------------------------------

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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------MSEQSKD
LSD---------------------------------------------------------
------------------------------------------------------------
--------PNF----------------------------A---------------AEA-P
SSEV--------------------------HSS-----------------PGVPEG---V
P--PS-----ET---------LAEPQSPPLGP------------T---------------
----AAPQAA--------------------------------------------------
------QPP--------------QAPSDEDD---------PKAL-QQA-A-EE--GR---
----------------------AHQAP----SAAQPG-PAPPAPAQLVQKAHELM-----
-------WYVLVKDQKKMIIW-FPDMV--KDVIGSYK-----KWCRSILRRTSLI-----
----LARVFGLH---------LRL-TSLHT---------MEFA-----------------
-------L----------------------------------VKALEPEELD-----RVA
----LSNRMPMTGLL-------LMILSLIYVKGRG------ARES---AVWNVLRIL---
-----GLR-PWK----KHSTFGDVRKLITEEFVQQ------NYLKYQRV-PYVEPPEYEF
----FWGSRASREIT--KLQIMEFLARVFKKDPQ----A-WPSRYRE---ALEEARALRE
ANPAA----------------------------------HCPRSSVSED-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------MRG-
-------------PSSSQASRGSR------------------------------------
-----------------------------------------------------------N
W-----------------------------------VIGPWP------------------
------------------------------------------------------------
------QCKTCI----LRS--KS---------------------------RGGPGN---A
-RSQGTTKISA--------------------------------------ASGS---PGLL
QSPQRACS---SPTAME-V--TPSIRSDQ----------------G-SRS-QEEEEP---
------------N------TLQALP------------ETVLLLEDAIDDKVADLV-----
-------AFLLLKYRTKELTT-QAEML--KTVSQDYQ-----ELFPVIFSQAFEC-----
----MQLVFGVD---------VRE-VDSSD---------HAYV-----------------
-------L----------------------------------VTALGL-TCN----EMPS
---SE-QSVPKTGLL-------INILGVIFMDGNC------APEE---DVWEVLGVM---
-----GVY-DSQ----EHFIYGEPRELLTKIWVQE------GYLEYWQV-AGSDPACYEF
----LWGSRAHAETS--KMKILEFLAKVNDTIPS----A-FPVWYEE---ALRDEEVRSQ
ARVAARDVVGG-------------------------------------------------
------------------------------------------------------------
-----------------------PG--------P----------------GSVL---GP-
------------------------------------------------------------
---------YPA---------------------ASLA-----------------------
------------------PREV--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------

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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------MPRGKK---SKLRARGKR-RET
-HD-----QLQGL-----------------------------------------------
-TG-------------PQATAEKQ------------------------------------
-----------------------------------------------------------E
-ESR-----------------------SSSSSSA-----V---------------CRGAR
RRSS----------------------------GSS-------V-------PQESQG---A
S--PTGYPDAGASCSKYDVAA----MGQDEKS------------PSTSRDASVSQESQ-G
ASPIGPPDAGISC---------SKS--------DEAAKGQNEKSPSTSRDASV-----PQ
ESQGASPTG---SPDADVS----GSKSDVAA---------------KGQ---DEESL---
-----------------------------SS-SKRAALFTTTDGDPLKRKANKMV-----
-------QFLQEKFEKKEPIL-KADML--KRLRRQYK-----PCFPEILKRTSER-----
----LTVFFGVE---------LKE-TDSSG---------ESYT-----------------
-------L----------------------------------VSKLGL-SSE----GILS
----GDNALPKSGLL-------MSILGLIFMRGNR------ATEE---EAWKFLGLL---
-----GIY-DGI----LHSIYGDARKIITEDLVQD------KYVVYRQV-CNSDPPCYEF
----LWGPRAHAETT--KMRVLRVLTEINNTSPG----L-YPHLYED---ALTDEVERAL
RLRA--------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------MPRGQK---SKLRAREKR-RET
-HG-----PPQGL-----------------------------------------------
-TG-------------PQVTAEKQ------------------------------------
-----------------------------------------------------------E
-ESR-----------------------SSSSSSA-----V---------------CRSAR
RRSS----------------------------DSS-------V-------PQESQG---A
S--PTGSPDAGVSCSKSDVAA----KGQDEKS------------PSTSRDASVSQESQ-G
ASPTGSPDAGVSC---------SKS--------DMAAKGQDEKSPSTSPDASV-----PQ
ETQGASPTG---SPDADVS----GSKSDVAA---------------KGQ---EGESI---
-----------------------------SP-SERTVFFTTADRDPLNRKASKMV-----
-------QFLQEKFEKKESIL-KADML--RRVRRQYK-----PRFPEILKRTSER-----
----LAVVFGVE---------LKE-MDSSG---------ESYT-----------------
-------L----------------------------------VSKLGL-SSE----GSLS
----GDNALPKSGLL-------MSLLGLIFMKGNR------ATEE---EVWEFLGVL---
-----GIY-DGI----LHSIYGDTRKIITEDLVQD------KYVVYRQV-RNSDPPRYEF
----LWGPRAHAETT--KMKVLRVLAEINNTSPG----L-YPHLYED---ALIDEVERAL
RLRA--------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------MFSWK------------------------------------------------
----------------------------------------------AS-KAR----SPLS
----PRYSLPGSTEV---------LTGCH-------------SYP---SRFLSASSF---
-----TSA----------------------------------------------------
------------------------------------------------------------
-------------------------LSTVNMPR---------------------------
----------------------GQKSK---------------------------------
-TR-----------------SRAKRQ-QSRREVPV---VQPTAE----E--------AG-
-SS-------------------PVD-QSA-GSSFPGGSAPQGVK-T-------------P
---------GSF-------------------GAGVSCTGSGIG---------GRNAAVLP
DTKSSDGTQAGTSIQ-HTLKDPI---MRKASVLIE------FLLDKF-KMKEAV--TR--
------------------------------------------------------------
----SEM---LAVVNKKYKEQFPEILRRTSARLELVFGLELKEIDPSTHSYL-LVGKLGL
STEGSL-SSNWGL-PRTG---LLM----------SVLGV----------IF--------M
-KGNR----A-T--EQEVWQFLHGVGVY--AGKKHLIFGEPEEFIR-DVVREN-------
---------YLEYRQVPGSDP---P--SYEFLWGPRAHAETTKMKVLEVLAKVNGT---V
------PSAFPNLYQLALRDQAGGVPRRRV-QGKGV---HSKAPS----QKSSNM-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------METQIRREG
LGCSPASIKRKK-KKDSG--HLGLQVSTMFSEDDFQST---EGAPSGPQI----------
---------QWSQDLPRVQVFRE----------QANQE---DRSPR-RTQRITGG-EV--
-----------------LWGPITQIFPTVWPADLTGVIMPLEQ-----------------
-----------------RSQ-HCKPE-E----------------GLQA----QED-NPG-
-------------LVGGAQALQAE------------------------------------
-----------------------------------------------------------E
Q-E---------------------------------------------------------
------------------------------------------------------------
---AASFSSTLN----VGT--LEE------------------------------------
---------VP--------------------------------------ATES---PSPP
QSPQGESS---SPAAMD-S--IFGSLSDE----------------GSSS--QEEEGP---
------------S------TSPDLI------------DPESFSQDILHDKIIDLV-----
-------HLLLRKYRVKGLIT-KAEML--GSVIKNYE-----DYFPEIFREASEC-----
----MQLLFGID---------VKE-VDPTS---------HSYV-----------------
-------L----------------------------------VTSLSL-SYD----GIRG
---DE-QSMPKSGLL-------IIVLGVIFMEGNC------VPEE---VMWEVLSIM---
-----GVY-AGR----EHFLFGEPKKLLTHDWVQE------KYLVYRQV-PGTDPACYEF
----LWGPRAHAETS--KMKVLAYIANANGRDPS----S-YPSLYED---ALREEEEGV-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------MPRGQK---NKHHRNRLKNKKH
-NQ-----EKVHPQKDE---------------------------------------SQEK
GHH-------------KRDDFQDH------------------------------------
-----------------------------------------------------------K
-EAR-------------------------DNAAV-----E---------------EKSSC
SSPS-V-------------------------PGE----------------TLEKPP---A
S--------------------------------------------------KTSSD----
----------------------------------------AGWLSC--------------
-----------VS----------SPATVCGD---------------ELEF-D--------
----------------DGTYFHCGGNS--LY-SEYRTCQENPCKHCLDMYVNLVE-----
-------QYVLYKFKMKKLID-RNKLI--DLIEPKYR-----YNFSDIFKRAFEN-----
----IEIVFAAS---------VIE-IDSTN---------HVYD-----------------
-------L----------------------------------VSKLKLPNKG-----RVC
----PGRGLPKTGLL-------MTILAMIFMNGTS------ASEE---DIWKFLNYM---
-----QVY-PGR----KHFIYREPRKLITQDFVKL------KYLEYKQI-SLSDPPCYRF
----QWGPKAYTETT--KMKVLEFMAKGSGVEPS----T-FSVQYTE---ALREENQKTK
IRKW-YPILAQKHC--------PGHS----------------------------------
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--H----Q------HVQK-----------VMKPQ--------------------------
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--------------------------------------MPVD-Q----------------
-----------------LSD-LRKV-----------------------------------
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----------------VNQ--LFLS---E---------------------EAA-------
----------T--------------------------------------PSPS-------
S--------------ASSP-----------------------------------------
--------------------PPSSV------------EAEALLQDALLAMMADLV-----
-------EFLLLKYCTKEPIT-KAEML--NVVLRDAQ-----DRFPDVLSRASEC-----
----MLLVFGLD---------LKE-VDPEE---------HTYT-----------------
-------L----------------------------------FPTLGL-TWD----GVLS
---DHELSLPKTGLL-------VVVLVVISLQGDR------APEE---VVWETLGVM---
-----GVC-AGM----VHCIYGEPRALLTQVCVQE------GYLEYRQV-PHSDPARYEF
----LWGPRAHAETS--RLKILEHLLRVNGRVPR----S-CRFLAAV---AVNEEEEGP-
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--------------------------------------MPRGRK---SKLRAREKR-RQA
-RS-----ETEGL-----------------------------------------------
-KS-------------AQATAAKE------------------------------------
-----------------------------------------------------------E
-GSP-------------------------SSSTH--------------------------
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------------------------ERSDERA---------------TM-Q-DE-ERP---
-----------------------------GT-SQASSTTDRSGRTPLDQKAILLV-----
-------QFLLRKYNMKETIT-KEDML--KYVIKKHK-----DHFHEILRRASEL-----
----MVLAFGID---------VKE-VDTTR---------HCYA-----------------
-------L----------------------------------ISKLQR-NRD----ERLS
----G-EIMPKTGLL-------MTVLCVIFMKGNC------ATEE---DIWEVLNVM---
-----GIY-AGK-----HFIYGEPKKLIT-EWVQE------KYLEYRQV--NSDPPRYEF
----LWGPRAHAETS--KMKVLEFLAKVHDTTPN----A-FPYWYEE---ALREEEERAR
NR-FAALARTN-AI----------------------------------------------
----------------------------------------------------------VS
--------------------AHI--R-----------------------VPSS-YFH---
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Query Results

"ENSGT00760000118824_0"

ENSGT00760000118824_0