ENSGT00760000118796_0 : Linker Region Query Results

------------------------------------------------------------
---------------------------------------------------------YSI
G--GYQKSCK--VS--ISAPRAFSSRSYSSRPS-----AHI-SSSSF-------------
---------------------------------------------------------S-V
G---------------------SS-----------SFLSG------------LGTGL---
--------------GLGG------------------------------------------
-----------------GYNGAG-------DMGGI------TAVTVNQNLLSSL----NL
EVDPNIQA--LCTQEKEEIETLNNKFASF------SDK--MH------------------
----LLEQKNK-MLETKWNLLQQ-KKM-----DRSNR--DSMFE-SYINNLLRQLDTLGQ
EKRKLEAELGN-MQGRVEDFKNK-YEEKINK-NE---MENEFVLIK--K---DVDEVYMN
KVVLESRLEGLTDEINFLRQLYEE-----EICGLQ-QISNT----SVVLSVDNSHSLDMD
RIIA-EVCTQYKEIAN-HSWAEAESVYQTK--YEELQVQAGKH-DDLRRMKTEISDMN--
WNISWLQNE-I--EALKS------------------------------------------
-----Q-RA--TLNASIADAEQ-GGELTL-KDANAKL----ARPEAALHQAKQGKARQLR
-YQDLMNVKLALDMEIATYGKLLEGEES---------------------------RLE-S
---GI---Q--------NMSIHSKTTSG--------------------------------
---------------YSG---------------------GLSL-----------------
---AYG------------------------------GLISPDLSYGLS------------
----------------------------------------------------------SL
SFSHT--------------------SSRAVVVKKI------ETREGKLVSESSDVLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MIARQQCVR-----G-GPRGFSCGSAIVGSG----KRG--AFSSVS---VSGGA----
-----------------------------------------GRCS-SGGFGSRSLYNLGG
N-KSISLSVAGSRQ-GA-CFGGAGG-----------FGT---------------------
---------------------------------------GGFG-----------------
---GGFGG----SFS--GKGGPGFP-VC--PAGGI------QEVTINQSLLTPL----HV
EIDPEIQK--VRT EEREQIKLLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWKLLQQQTTST----SSKNL--EPLFE-TYLSVLRKQLDTLVN
DKGRLQSELKT-MQDSVEDFKTK-YEEEINKRTA---AENDFVVLK--K---DVDAAYMN
KVELEAKVDSLNDEINFLKVLYDA-----ELSQMQTHVSDM----SVVLSMDNNRNLDLD
SVIA-EVRAQYEEIAQ-RSKAEAEALYQTK--VQQLQISVDQHGDNLKNTKSEIAELN--
RMIQRLRAE-I--ENIKK------------------------------------------
-----Q-CQ--TLQASVADAEQ-RGENAL-KDAHSKR----IELETALQQAKEELARMLR
EYQELMSVKLALDIEIATYRKLLEGEE--------------------------C-RMS-G
ECQSA---V--------SISVVGGSTSTGG------------------------------
---------------ISG-G---LGS-----------------------------GS---
---GFGL------------------------SSGFGSG--SGSGFGF--G-GS-------
----VSGSSSSKIISTTTLNKRR-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSM
R--VTQKSYK--VST--SGPRAFSSHSYTSRPG-----SRI-SSSSF-------------
-------------------------------------------------------SRAGS
S---------------------SS------------------------------------
------------------------------------------------------------
-------------------------------FGAA------WAVQVNQSLLNPL----NL
EVDPNIQA--VHI QEKEQIKNLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQQ-QKT-----SRSNM--DNMFK-SYINNLRRQLDTLGQ
EKLKLEAELGN-TQGMGEDFKSK-YEDEINKRTE---MENEFVLIK--K---DVDEAYMN
KVELESRLEGLTDEINFLRQLYEE-----EIRELQSQISDT----SVVLSMDNSRSLDLD
GIIA-EIKVQYEEIAN-RSRAEVESMYQIK--YEELQTLAGKHGDDLRRTKSEISEMN--
RSISRLQAE-I--EALKG------------------------------------------
-----Q-RA--ALEAAIANAGQ-RGEMAI-KDANAKL----AQLESALQKAKQDMAQQLR
KYQELMNVKLALDIEIATYCKLLEGEEN---------------------------RLE-A
---GM-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQSSVS--FR-SGGSRSFSAASAITPS-----VSRT-SFTSV---SRSGGGGGGS
---RIS--------------------------FG-------GV-SGLGSYGSRSLYNVGS
S-KRISINSG----GG--AFRGR-------------SIGG--A----GAGYGFGSGA-G-
--------------GGFGFG--GGSFGLGAG-FGG-----------------GA----GF
G-----GGYGG-GFGGPGFP------VC--PPGGI------QEVTINQSLLTPL----NL
EIDPTIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVRQNL--EPLFE-QYINNLRRQLDGVLG
ERGRLDSELRN-MQDLVEDFKNK-YEDEINKRTT---AENEFVMLK--K---DVDAAYMN
KVELEAKVDALMDEINFLKMFFDA-----ELSQMQTHISDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEDIAN-RSRTEAESWYQTK--YEELQQTAGRHGDDLRNTKHEISEMN--
RMIQRLRAE-I--DNVKK------------------------------------------
-----Q-CA--NLQNAIADAEQ-RGELAL-KDARNKL----TELEEALQKAKQDMARLMR
DYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VG-PV-------N-ISVVTNSL----------------------------------
------------SSGYGGSS----------------FGG--GYGGGIGGG----------
----------------------------------IGGGYGGGIGGGG-SG----SYYSS-
-----------------------SSGG-------GLG--GGLSVGG-------------S
GFSAS---SGRGI----------GGG-SSSSVKFV----STTS-S---------------
------------------------------------------------------------
-------------SRRSFKS----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--M-SRQSTIT--FHSG-SRKSFSTASATMPAG----AGHS-RFSSIS-VARSTG--GSG
GLGRIS--------------------------SA------------GTNFGSRSLYNLGG
T-KRVSIGGC-GSS-----FRSG-------------FGG--RA----STGFGI-----S-
--------------NGCGYG--GGIGGSF-------------------------------
--------------GGSGLP------VC--PSGGI------QEVTINQSLLTPL----NL
QIDPSIQR--VRK EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQEQGSR----TVRQSL--EPLFE-AYINDLRRQLDTITT
ERGRMEAELKN-MQEVVEDFKVR-YEDEINKRTA---AENEFVALK--K---DVDGAYMN
KVDLEAKVDALTDQINFHRMIFEA-----ELSQMQTQVSDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEDIAN-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEISEVN--
RMIQRLRAE-I--DSVKK------------------------------------------
-----Q-CS--SLQTAIADAEQ-RGELAL-KDARAKL----VDLEEALQKAKQDMARLLR
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VS-PVNIS--------VVTSTV----------------------------------
------------SSGYGSGG--GIA-----------------------------------
---------------------------------------GGSLGLGGGSS----YSFTT-
-----------------------SG-------GHSLN--T--GLGS-------------S
GFTTS---SSRGPAG------------SGSSIKFI----STTS-----------------
------------------------------------------------------------
------------SSRKNYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSR
QCS-NRSSCRI--G----GGRGFSSGSAGLVS-----FHRK-STSSS--VRRSGGG----
GGGRFS------------------------GGFCGSSGG------SGSGFGSKSLVNLGG
G-RSISMSVAGGGH-CGGM--GGG-----------SFGGGSFGG------GGFGG-----
--------------G--------------------GFGGGGF------------GGGFG-
S---------G-GYGGGRFGGGFGP-VC--PPGGI------QEVTINQSLLQPL----NM
EVDPEIQK--VKS QEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNQ-VLQTKWELLQQVDTTT----RTHNL--DPYFE-TYIANLRKQVDQLKS
DQSRMDSELKN-MQDMVEDYRNK-YEDEINKRTN---AENEFVTIK--K---DVDSAYMN
KVELQAKLDNLQQEIDFLTALYRE-----ELSQMQTHISET----NVILSMDNNRTLDLD
SIIS-EVKAQYDDICQ-RSKAEAETFYQSK--YEELQITAGKHGDSVKTSKMEISELN--
RVIQRIRSE-I--DSVKK------------------------------------------
-----Q-IA--HMQQNISEAEQ-RGENAL-KDAQKKL----NELEEAMTQAKEELARLLR
DYQELMNTKLALDMEIATYRTLLEGEE--------------------------I-R----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

-------------------------------------------MHREQ----SG------
-----------------VGVHS-----QPPGLEWKQLLAPSLVSSWFGPPASTPASIMSI
R--VTQKSYK--MST--SGPRAFSSRSYTSGPS-----ARI-SSSGF-------------
-------------------------------------------------------SRVGS
S----------------------S-----------GFRSG------------LGLGL---
--------------G---------------------------------------------
------------------GGYA------------G------AAVTVNQSLLSPL----NL
EVDPNIQA--VRNQEKEEIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQQ-QKT-----ARSNM--DGMFE-NYISNLRRQLDTLGQ
DKLKLEAELGN-MQGLVEDFKNK-YEDEINKRTE---MENEFVLIK--K---DVDEAYMN
KVELESRLDGLTDEINFLRQLHEE-----EIRELQSQISDT----SVVLSMDNSRSLDMD
SIIA-EVRAQYEDIAN-RSRAEAESMYQTK--YEELEVLAGKHGDDLRRTKTEISDMN--
RNISRLQAE-I--EGLKG------------------------------------------
-----Q-RA--SLEAAIADAEQ-RGKLAV-EDAKAKV----DELNAALQRAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEES---------------------------RWV-W
---GS---L--------TGP--GVGRVD--------------------------------
---------------TAC---------------------GLSS-----------------
---AYG------------------------------GLTSPGLSYGLS--------SF--
--------------------------------PP--------SFGSGG---------SSG
SFSRT-------------------SSSRAVVVKKI------ETRDGKLVSESSDVLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MIARQQGVR-----S-GSRAFSSGSAV-VGG----GKRV-AFSSAS---VSGGA----
-----------------------------------------GRCS-SGGFGSRSLYNFRG
N-KNI-CSVAGSRQ-GA-GFGYAGG-----------FGG---------------------
-------------AGSFG----------------AGFGAGGFG-----------------
---GGFGG----SFN--GRGGSGFP-VC--PAGGI------QEVTINQSLLTPL----QV
EIDPEIQK--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWKLLQQQTTTT----SPRNL--DPFFE-AYISALRKQLDALAS
EKGRMLSELKM-MQDSVEDFKTK-YEDEINKRTA---AENDFVVLK--K---DVDAAYMI
KVDLEAKVDSINDEINFLRVLYEA-----ELSQMQSHVSDT----SVVLSMDNNRDLDLD
SIIA-EVRAQYEEIAQ-RSKAEVEAWYQTK--VQQLQTSVDQHGDNLKSTKNEISELN--
RMIQRLRAE-I--ENVKK------------------------------------------
-----Q-CQ--TLQTSVADAEQ-RGELAL-KDAYSKR----TELEAALQKAKEELTRMLR
EYQELLSVKLALDVEIATYRKLLEGEE--------------------------C-RMS-G
ECQSA---V--------SISVVGGSISTGG------------------------------
--------------------------------------------------------I---
---GFGL------------------------GSGFGSG--CGSGFGF--S-GG-------
----VSGSSGNKIISTTS-LT-RRSQL---------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSV
H-------------Y---SAQVFSSRSAALPRR----GAQG-RLNAG----RQGG-----
----------------------------------------------FA--SSHSLYSLG-
------------TS-RPRMPV--GS-----------------------------------
---------------VYG------------------------------------------
----------------G-------A-----VGAGI------REVTINQNLLAPL----RS
NIDPSIRH--VRQ EEREQIKTLNNKFASF------IDK--VQ------------------
----FLEQQNK-MLETKWALLQEQKSA-----KSSSL--PRIFE-AQIAGLRGQLEKLQL
DRGRLEAELRS-IQDVVEDFKNK-YEEEMNHRMA---AENEFVMLK--K---DVDTAFMN
KVDLQAKVDGLCDEINFLKTLHET-----ELAELQSQISDT----SVVLSMDNNRSLDMD
SIIA-EVKAQYEEMAN-RSRAEAEALYQKK--FEILQAQSGKHGEDLRNTRNEIVEMN--
RAIQRLQAE-I--DNIKN------------------------------------------
-----Q-RA--KLEAAIAEAEE-RGELAL-QDAHGKQ----RELEAALQQAKQDMARQLR
EYQELMNIKLALDIEIATYRKLLEGEE--------------------------S-RLT-R
DGVGA---A--------NISV---------------------------------------
----MNSS-G--------GG----------------GGIGLVFGG-----TMGSNALRFS
S------GGTGS------------------------------------------------
--------VKAYSIRTTSTTRESTLH----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSV
R--VTQKSYK--VS--TSGPRAFSSHSYTSGPG-----DHI-SSSSF-------------
-------------------------------------------------------SQVGS
-----------------------S-----------SFRGG------------LGG-----
---------------GYG------------------------------------------
-----------------GASG----------MGGI------TAITVNQSLLSPL----NL
EMDPNIQA--VHT QEKQQIKTLNNKFASF------IDK----------------------
--------LNK-MLETKWSLLQQ-QKT-----AQRNM--DNMFE-SYINNLRQQLKTLGQ
EKLKLEAELGN-TQGLGEDFKNK-YEDENHKRAE---VENEI------------------
-VELESRLEGLPDEINFLKQLYEE-----EIWELQSQISDT----SVVLSMDNSLSLGMN
SIIS-EVKAPYEEIAN-S-----ESMYQIK--YEELQMLAGKHKDDLWCTETEISEMN--
RNISRHQAE-T--EGLKG------------------------------------------
-----H-RA--SLEACIADAEQ-RGELAI-KDANAKL----SDLEVSLQWAKQDM-----
---ELMNVKLALDIEIATYRKLLEGEES---------------------------WLE-S
---GM---Q--------NMSIYTKTTSG--------------------------------
---------------YAG---------------------GLNS-----------------
---AYG------------------------------GLTSP-------------------
------------------------------------------RFGSGV---------GST
SFSCT-------------------STTRAVFSSDI------LPK----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MIARQQCVR-----G-GPRGFSCGSAIVGGG----KRG--AFSSVS---VSGGA----
-----------------------------------------GRCS-SGGFGSRSLYNLGG
N-KSISMSVAGSRQ-GA-CFGGAGG-----------FGT---------------------
---------------------------------------GGFG-----------------
---GGFGG----SFS--GKGGPGFP-VC--PAGGI------QEVTINQSLLTPL----HV
EIDPEIQK--VRT EEREQIKLLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWKLLQQQTTST----SSKNL--EPLFE-TYLSVLRKQLDTLVN
DKGRLQSELKT-MQDSVEDFKTK-YEEEINKRTA---AENDFVVLK--K---DVDAAYMN
KVELEAKVDSLNDEINFLKVLYDA-----ELSQMQTHVSDM----SVVLSMDNNRNLDLD
SIIA-EVRAQYEEIAQ-RSKAEAEALYQTK--VQQLQISVDQHGDNLKNTKSEIAELN--
RMIQRLRAE-I--ENIKK------------------------------------------
-----Q-CQ--TLQASVADAEQ-RGENAL-KDAHSKR----IELEAALQQAKEELARMLR
EYQELMSVKLALDIEIATYRKLLEGEE--------------------------C-RMS-G
ECQSA---V--------SISVVGGSTSTGG------------------------------
---------------ISG-G---LGS-----------------------------GS---
---GFGL------------------------SSGFGSG--SGSGFGF--G-GS-------
----VSGSSSSKIISTTTLNKRR-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
-------------------------------MT------QRSS---VTIKSGGTRNF---
-------------------SAASASLLPACRPG----FSSF-SVSQS----G--------
---------------------------------------KSLG----GGFGTRSLHSFGG
S-KRIS---GYRSS-R-ASFGGAAC-----------------------------------
---------------GLGIG-------SMGYRVGG-------------------------
------------AFGGYGFGGGMAP-----GAGGI------HEVTVNQSLLTPL----HL
EIDPSLQR--VRK EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWSLLQEYKTT-----RT-NL--EPMFE-AYITNLRRQLDCLGG
ERGRLETELKS-MQDVVEDFKNK-YEEEIHKRTA---AENEFVVLK--K---DVDAAYMN
KVELEAKMDALMDEINFLRAFYEA-----ELAQLHAQISET----SVVLSMDNNRSLDLD
SIIA-EVKAQYEDIAN-RSRAEAESWYQTK--YEELQRSAGRHGDDLRTTKMEISELN--
RAMQRLRSE-I--DNLKK------------------------------------------
-----Q-CA--SLQASIADAEQ-RGELAL-KDAKNKL----AELEEALQKAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEE--------------------------C-RLT-G
EGVGA---V--------NISVVSSSGGTGYSGGG--------------------------
-G----LC-MGGGTGYS-------------------G----GGGLCMGGGGYSGGSLSYS
SASGR-SVSGSS------------------------------------------------
--------SSMRIVSKTSSSKKSYRS----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
-----------------------------PGLPAQLPSGLRT-----GDTAGPAAAMS--
--------------R----SVSFSSRSVAVP-G----VSQI-RVSSV-------------
-----------------------------------SSVRGGSGLGKAGGFGSSSLYNLGS
ANKRISLGGS--------SSYSVRS-----------------------------------
---------------GYGYG-------GV-------------------------------
------------GF------GGAIA-----PGAGI------QEVTVNQSLLTPL----NL
EIDPNIQR--VRKEEKEQIKTLNNRFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQDQKTT-----RS-NI--VPMFE-AYISNLRRQLDGLLN
DKGRLEGELRN-MQDLVEDFKAK-YEDEINKRTT---AENEFVVLK--K---DVDAAYMN
KVELEAKVDALTDEINFLRSLYEA-----ELRELQAQISDT----SVVLSMDNSRNLDLD
SIIA-EVKAQYEDIAN-RSRAEAESWYQSK--FEALQVTAGKHGDDLRNTKNEITEIN--
RVIQRLQGE-I--ENAKA------------------------------------------
-----Q-RA--KLEAAIAEAEE-RGELAI-KDARTKL----EELEAALQKAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEE--------------------------S-RLA-G
DGVGS---V--------NISMVTSSGGG----SS--------------------------
-G----FL-G----------------------------GGVRGGLALGAGM-GSGALGFS
S-------G-GS------------------------------------------------
--------SKSYTVTTTSS-TRSFRK----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTQKSYK--VS--TSGPLAFSSHSYTSGPG-----ACI-SSLS--------------
-------------------------------------------------------SRVGS
-----------------------S-----------SFRGG------------LGR-----
---------------GYG------------------------------------------
-----------------GASG----------MGGI------TTVTVNQSLLSPL----NL
EVDPSIQA----------IKTLNNKFASF------IDK------------------------------QNK-MLETKWSLLQQ-QKT-----AQSNM--DNMFQ-SYINNLRRQLETVDQEKLKLEAELGN-IQGLVEDFKNK-YEDETNKCRE---MENEFVLIK--K---DVDEAYMNKVELESRLEGLTDEINFLRQLYEE-----DIPELQSQISDT----SVVLSMDNSSSLDMDSIIA-EVKAQYEITNR--------SRYQIE--YEELQ-----TLDDLRHTKAEISEMN--RNISQLQAE-I--EGLKG-----------------------------------------------Q-RA--SLEAAIADAEQ-RGDLAI-KDANAKL----SQLQAALQRAKQDMVRQLREYQELMNAKLALDIEIATYRKLLEGEES---------------------------RLE-S---GM---R--------NMSIHTKTTSS-----------------------------------------------YAG---------------------GLSS--------------------AYG------------------------------GLTSPGLSYDLG---------------------------------------------S--------SFGSGT---------GSSSFSCT-------------------SYTRAVVVKKI------ETCDGKLVSKSSEVLSK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IKTLNNKFASF------IDK----------------------
--------QNK-MLETKWSLLQQ-QKT-----AQSNM--DNMFQ-SYINNLRRQLETVDQ
EKLKLEAELGN-IQGLVEDFKNK-YEDETNKCRE---MENEFVLIK--K---DVDEAYMN
KVELESRLEGLTDEINFLRQLYEE-----DIPELQSQISDT----SVVLSMDNSSSLDMD
SIIA-EVKAQYEITNR--------SRYQIE--YEELQ-----TLDDLRHTKAEISEMN--
RNISQLQAE-I--EGLKG------------------------------------------
-----Q-RA--SLEAAIADAEQ-RGDLAI-KDANAKL----SQLQAALQRAKQDMVRQLR
EYQELMNAKLALDIEIATYRKLLEGEES---------------------------RLE-S
---GM---R--------NMSIHTKTTSS--------------------------------
---------------YAG---------------------GLSS-----------------
---AYG------------------------------GLTSPGLSYDLG------------
---------------------------------S--------SFGSGT---------GSS
SFSCT-------------------SYTRAVVVKKI------ETCDGKLVSKSSEVLSK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQACKK--SF-SCGSQGFSGHSAVVSG------SSR-S-SC---VARSGAA-S--
-----GG-------------------------ASGFR----SG---AGSLGSHSLYSLGG
S-KSISISVAAGGS-RAGSFSGGRS------SCGSGFGSGYGGSFGGSRG----------
------MGA-------------------------------------------GFGGTSGF
GGAG--------GFGR---PGSFGP-GS--CPGGI------QEVTINQSLLQPL----NV
EIDPQIGQ--VKA QEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWELLQQQTTRSG--SGPQSL--EPFFE-SYISCLRKQLDTLLG
AKGSLEGELKS-MQDLVEDFKKK-YEEEINRRTA---AENEFVGLK--K---DVDGAFMN
KVDLQAKVDSLTDEINFLRTLYDM-----ELSQMQSHVSDT----SVVLSMDNNRCLDLD
SIIA-EVKAQYEDIAQ-KSKAEAEALYQTK--LGELQTTAGRHGDDLRSTKSEIMDLN--
RMIQRLRAE-I--ENVKK------------------------------------------
-----Q-NT--NMQTSIAEAEQ-RGERAL-KDADTKL----QDLQVALQKAKEDMARLLK
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
VFQNA---V--------SISVVSNVTS---------------------------------
--------TS-S----SGGFRGTGGS----NF--R----GD-------------------
----------------SSGRSG------------------------GSSS----------
----------------------------SSRGSS------GSRLGSGGSI--SV-SQQRM
GFNSG--GS-QTSVGSSYKS----GRGGSSSVQFS----QTT------------------
------------------------------------------------------------
----------SSS-QQRSK-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------M--
----SRQASKT--S--GGGSQGFSGRSAVVSG------SSR-M-SC---VARSGGA-G--
-----GG-------------------------AYGFR----SG---AGGFGSRSLYNLGG
N-KSVSISVAAGSS-RAGGFGGGRS------S--CAFAGGYGG------------GFGGG
--R--GMGGGFGGAGGFG--------GAGGFGGA-----GGFGGPGGFGGPGVFGGPGSF
GGPGGF---------G---P------GG--FPGGI------QEVTINQSLLQPL----NV
EIDPQIGQ--VKA QEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQQQGTSSI--SGTNNL--EPLFE-NHINYLRSYLDNILG
ERGRLDSELKN-MEDLVEDFKKK-YEDEINKRTA---AENEFVTLK--K---DVDSAYMN
KVELQAKVDALIDEIDFLRTLYDA-----ELSQMQSHISDT----SVVLSMDNNRSLDLD
SIIA-EVRAQYEDITQ-RSKAEAEALYQTK--LGELQTTAGRHGDDLRNTKSEIIELN--
RMIQRLQAE-I--EGVKK------------------------------------------
-----Q-NA--NLQTAIAEAEQ-HGEMAL-KDANAKL----QELQAALQQAKDDLARLLR
DYQELMNVKLALDVEIATYRKLLEGEE--------------------------Y-RMS-G
ECPSA---V--------SISVVSSST----------------------------------
--------TSASAGGYGGGYGG-------------GLGGGLGGGF---------------
--------------------SA----GGG-----------SGSGFGRGGG--GGIGG---
---GFVG------------------GS--------------------SSG--F-SGGSGF
GSISG--AR-YGVSRGGFSS----ASNRGGSIKFS----QSS------------------
------------------------------------------------------------
----------QSS-QRYSR-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MIARQSSVR-----A-ASRGFSSGSAI-AGG----VKRV-AFSSGS---MSGGA----
-----------------------------------------GRCS-SGGFGSRSLYNLGG
H-KSISMSVAGSCQ-GG-GYGGAGG-----------FGVGG-------------------
----------------YG----------------AGFGAGGFG-----------------
---GGFGG----SFN--GRGGPGFP-VC--PAGGI------QEVTINQSLLTPL----QV
EIDPEIQK--IRTA EREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQQQTTTT----SPKNL--DPFFE-TYINALRKNLDMLSN
DKGRLQSELKM-MQDSVEDFKTK-YEEEINKRTA---AENDFVVLK--K---DVDAAYMI
KVELEAKMESLKDEINFMRVLYEA-----ELAQMQTHVSDT----SVVLSMDNNRNLDLD
SIIA-EVRAQYEDIAR-KSKAEVESWYQIK--VQQLQMSADQHGDSLKTTKNEISELN--
RMIQRMRAE-I--ENIKK------------------------------------------
-----Q-SQ--TLQASVADAEQ-RGELAL-KDAYSKQ----AELENALQKAKENLARLLR
DYQSLLNVKLALDVEIATYKKLLEGEE--------------------------C-RMS-G
ECKSA---V--------SISVVGGSASIGG------------------------------
------------------------S------------------------------GL---
---GLGG------------------------GFCSGSG--SGSGFGF--G-GG-------
----IYGGSGSKITSSATIT--KRSPR---------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
----------------------------------------------------------MR
S-SLSRQTFST--------KGGFSSNSASGG---GGSRMRT-SYSSVT-MSRGS--GGG-
--------------------------G---GV---------RSGSSSGGFGSRSLYNLGG
--KNISVSMACGASSG-RAL----------------------------------------
--------------GGFG--------------------SGAYV-----------------
-------GLG-------AGRQTFGP-VC--PPGGI------QEVTVNQSLLTPL----NV
EIDPEIQR--VRTQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQSQNTG--VAR-SL--EPFFE-NYLSTLRRQLDTKQS
ERGRLDMELRN-VQDNLEDFKNK-YEDEINKRTA---LENEFVVLK--K---DVDAAFMG
RVDLHGKVDSLTQEIDFLQHLFEM-----ELSQVQTNVSDT----NVILSMDNNRNLDLD
SIIA-EVKAQYELIAQ-KSRAEAESWYQTK--YEELQVTAGKHGDSLRDTKNEIAELT--
RTTQRLQGE-V--DAAKK------------------------------------------
-----Q-CQ--QLQTAIAEAEQ-NGEMAL-KDAKKKL----SDLDSALHQAKEDMARMLR
EYQDLVSVKLALDVEIATYRKLLESEE--------------------------S-RMS-G
DCPSA---I--------SISVTGNSTSVCA------------------------------
-----------------GG--------------AAGFGNGLSLGGA---GG--ASKGGFG
AS----------------------------------------VSYGA----------A--
KGGQVSG--GTSILRKT--TTVKTSSRRY-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
W--VTQKSYK--MS--ASGPGAFSSRSYLRVPG-----ARV-SSSVF-------------
-------------------------------------------------------SWVGG
S----------------------S-----------GFRGG------------LGM-----
------------------------------------------------------------
-------------------SRAR-------GMRGI------MAVSLNQSLLSPL----KL
EMDPNIKD--VHTQEKLQIKTLNNKFASF------INK---L------------------
----YLEQQNT-ILESKWSLLQQ-QET-----ARSNM--DHMFK-SYINNSRG-SHTVAQ
EKLKLEVELGN-IQGLVGDVENK-HEEEIKERVD---TDNEFVLIK--K---DMDEIYMN
IVELESRLERLTDEISFLRH---E-----VIRELQSQVLDT----SVVLSTDNSSSVDLN
SIIA-EVKASDEEIAN-CSQAEAETMYQIK--YKELQTLAGKHGVDRWLRKIGISEMN--
QNISQHQAETD-------------------------------------------------
-----Q-RA--SLEATIAEAEQ-HGELAV-KDANTKG----AELEAAPQGAKQDLARQLR
EHQELRNIKLALDIEITSCWRPR------------------------------------A
---GW---S--------NMSIHAKTTSS--------------------------------
---------------YSG---------------------GLSS-----------------
---VYG------------------------------RLTSLAST----------------
--------------------------------LS--------SFDSGR---------DSS
ASSQG-------------------SSFKTVVVKKI------KTCAGRLVSESPAVLSK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSR
QFS-SRSAYRS--GGGLGSLGGFSAGSAGIIS-----YQRR-TTSSS--SRRSGGGG---
G--RVS------------------------GGFCSGGAGG-----GGGGFGSRSLVNLGG
S-KSISMSVARGGG-H-SGFGGG---------C-G---GGSFGG------GGFGS-----
------------------FG-SGG----GGYG-GGGYGGGGYGGGG--YG----GGGYG-
G---------G-GYGGGGYGGGSGP-VC--PPGGI------QEVTINQSLLQPL----NV
EIDPEIQR--VKSQEREQIKSLNNQFVNF------IDK--VR------------------
----FLEQQNQ-VLQTKWEMLQQVDTSV----RTHNL--EPLFE-QYISKLRNDVEHLKS
DQNRMDMELKN-MQDMVEDYRNK-YEDEINKRTN---AENEFVTLK--K---DVDSAYMS
KVDLQAKVDNLQNDIAFLTMLYNE-----ELSQMQTQISET----NVILSMDNNRSLDLN
SIID-EVKAQYEDIAQ-RSKAEAESVYQNK--YEELQMTAGKHGDSVKNSKMEISELN--
RVMQRLRSE-I--DNVKK------------------------------------------
-----Q-IS--NLQQSISDAEQ-RGEKAL-KDAQNKL----NDLEDALQQAKEDLAKLLK
DYQELMNVKLALDMEIATYRTLLEGEE--------------------------M-RMS-G
ECPP-N--V--------SVSVSTSHTSISG------------------------------
------------GGGRGGGG--YGSG----GGGSGSYGSG-----------GGSYGS---
---GGGGG-S-------------------------------GSGSYG-SG-GGGRGSYGG
SGGGSYG-GSG-----------GGSSGGH-RGGS------GGGGSSSGGRGSG--GSSSG
G--RG--S----GGGSSGGSGGVKSSGGSSSVKFI----STS------------------
------------------------------------------------------------
----------YSR-GTR-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSTKSTIR--SQ--TSHRGFSAGSARVPG-----LNRS-GFSSVS-VCRSRGSGGSG
A-------------------------------MC-----------GGAGFGSRSLYGVGS
S-KRISIGGG----SC--GVGGG-------------YGS--RI----GGGFGFGGG----
--------------------------V------GS-----------------GF----GF
G--GG-AGFGG-GYGGAGFP------VC--PPGGI------QEVTINQSLLTPL----NL
QIDPTIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVRQNL--EPLFE-QYISNLRRQLDSIIG
DRGRLDSELRS-MQDTVEDYKNK-YEDEINKRTA---AENEFVTLK--K---DVDAAYMN
KVELQAKTDSLTDEINFLRALYDA-----ELSQMQTHISDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEEIAQ-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEIAEIN--
RMIQRLRSE-I--DHVKK------------------------------------------
-----Q-CA--NLQAAIAEAEQ-RGEMAL-KDARGKL----EGLEDALQKAKQDMARLLK
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLN-G
EG--VG-PV-------N-ISVVQSTM----------------------------------
------------SSGYGSAG-------------------GA--S----------------
----------------------------------------SSLGLGGG-S----SYSYG-
-------------------------SS--------------HGLG--------------G
GFSSG---SGRGIS--GGFS--SSGGS-SSTIKYS----STS------------------
------------------------------------------------------------
------------SSRKSYRH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--M-SRQSTIT--FHSG-SRRGFSTTSATTPA-----AGRS-RFSSVS-VARSTG--GSG
GLGRIN--------------------------GA------------GAGFGSRSLYNLGG
A-KRXXXXXXXXXX-----XRSG-------------FGG--WA----STGFGI-----S-
--------------NGFGHG--PGIGGSF-------------------------------
--------------GGPGFP------VC--PSGGI------QEVTINQSLLTPL----NL
QIDPSLQR--VRK EEHEQIKTLNNKFACF------IDK--VC------------------
----FVEQQNK-VLETKWNLLQEQGSR----TVKQSL--EPLFD-TYINDLRRQLDGITT
ERGRLEAELRN-MQEVVEDFKIR-CEDEINKCMA---AENEFVTLK--K---DMDGAYMN
KVELEAKVDALTDQINFYQMIFEV-----ELSQRQTQVSDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEDIAN-HSRAEAESWYQSK--YEELQVTAGRHGNDLCNTKQEISEVN--
RMIQRLRAE-I--DSVKK------------------------------------------
-----Q-CS--SLQTAIADAEQ-RGELAL-KDAQAKL----VGPEEALQKAKQDMARLLR
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VS-PVNIS--------VVTSTI----------------------------------
------------SSGYGSGS--GIA-----------------------------------
---------------------------------------GGSLGLGGGNG----YSFTT-
-----------------------SG-------GHSLG--T--GLGG-------------S
GFTAS---SSLGLGG------------SGSRVKFI----STKS-----------------
------------------------------------------------------------
------------SSRKNYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
------LQVN--VST--SGPRAFSSRSYTSGPG-----SRI-SSSSF-------------
-------------------------------------------------------SRVGS
S----------------------S-----------SFRGG------------LG------
-------------------L----------------------------------------
---------------GGY-GGAV----------------------VNQSLLNPL----NL
EVDPNIQA--VRIQEKEQIKNLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQR-QKT-----SRSNM--DNMFE-SYINNLRRQLDTLGQ
EKLKLEAELGN-MQGMVEDFKNK-YEDEINKRTE---MENEFVLIK--K---DVDEAYMN
KVELESRLEGLTDEINFLRQLYEE-----EIRELQSQISDT----SVVLSMDNSRSLDLD
GIIA-EVKAQYEEIAN-RSRAEAESMYQIK--YEELQTLAGKHGDDLRRTKSEISEMN--
RSISRLQAE-I--EALKG------------------------------------------
-----Q-RA--ALEAAIADAEQ-RGEMAI-KDANAKL----AQLESALQKAKQDMARQVC
EYQELMNVKLALDIEIATYCKLLEGEEN---------------------------RLE-A
---GM---Q--------NLSIHTKTTSG--------------------------------
---------------YAG---------------------MVSS-----------------
---PYG------------------------------GLTS--------------------
----------------------------------------------------------PG
F---T-------------------RTKSAVVVKKI------ETRDGKLVSETSDVLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQACKK--SF-SCGSQGFSGHSAVVSGG-----SSR-R-SC---VARTGAA-R--
-----GG-------------------------ACGFR----SG---AGSFGSQSLYSLGG
S-RSISMSVAAGGS-QTGGFSGGLG------SCGGGY----GGGFGGSRG----------
------MGG-------------------------------------------GFGGASGF
GGAS--------GFGR---PGGFGP-GG--CPGGI------QEVTINQSLLQPL----NV
EIDPQIGQ--VKA QEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQQQTKGSG--SGPQSL--EPFFE-SYISCLRKTLDSLMG
EKGSLEGELKG-MQDLVEDFKRK-YEEEINRRTT---AENEFVGVK--K---DVDVAFMN
KVELQAKVDSLTDEINFLRTLYDM-----ELSQMQSHVSDT----SVVLSMDNNRCLDLD
SIIS-EVKAQYEDIAQ-RSKAEAEALYQTK--LGELQTTAGKHGDDLRSTKSEIMDLN--
RMIQRLRAE-M--ENIKK------------------------------------------
-----Q-NT--NLQTSIAEAEQ-RGDRAL-KDADAKL----QDLQAAMQKAKDDLARMLR
DYQELMNIKLALDVEIATYRKLLEGEE--------------------------C-RMS-G
ECQSD---V--------CISVVSNVTS---------------------------------
--------TS-S----SGGFRGAGGS----NY--G----GD-------------------
----------------SSGRSS--------------------------------------
----------------------------SSRDST------GSRLGREGSV--SV-SQRGM
GFNSG--GT-QASVGGSYKS----SRGSSSSVHFS----QTT------------------
------------------------------------------------------------
----------SSS-QQRSK-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MST
KTVIR---------SQT-SHRGFSAGSARLPG-----LTRS-GFSSVS-VCRSRGSG---
-----G-----------------------------S----RAVCG-GAGFGSRSLCGVGS
S-QRMSVGGGSCGI-G-GGYGGRFG-----------------------------------
--------------GSFSYG----LGAGGSLGFGA---------------------G---
-----------AGFGG-GYGGAGFP-VC--PPGGI------QEVTINQSLLAPM----NL
QIDSTIQR--VRT EEREQIKTLNNKFASF------IDK--LR------------------
----FLEQQNK-VLYTKWALLQDLGSDV----ISPVL--EALFA-YYVDFL-GNLGGLVG
QKGPLDSELRS-MKNRVEDYKSK-YEDEINRRTA---AENKFMTLK--K---DVDAAFMS
NVELQAKADSLTDEIDFLTAVFEA-----ELSQMQTRISDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEEIAK-RSRAEAESWYQTK--SEELQIQLADTG-DLRNTK-QISEIN--
RMIQRLRSE-I--HVK-K------------------------------------------
-----Q-IA--T-CKAIAEAEQ-RGEMAL-KD-RGKL----EGL-DALQKAKQDMARLLK
EYQDLMNVKLL-DVE-ITYRTLLEGEE--------------------------C-RMN-G
EGV-G----------------VNISVVQPP------------------------------
------------CQSYGS----AGGA----SS----------------------------
---SIG--------------------------------------LGGSSS----FSYGGS
----SI-----------------------------------------------------G
GFSAG--SG-RGISSGS---SSGGSSST---I-KY----TTT------------------
------------------------------------------------------------
----------SST-RKSYRP----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MASTSTTIR--SH-SSSRRGFSAGSARLPG-----VSRS-GFSSVS-VSRSRGSGGLG
G-------------------------------AC-----------GGAGFGSRSLYGLGG
S-KRISIGGG----SC--AIGGG-------------YGS--RA----GGSYGFGG-A-G-
--------------SGFGFG--GG--A------GI-----------------GF----GL
G--GG-AGLAG-GFGGPGFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPAIQR--VRA EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVRQNL--EPLFE-QYINNLRRQLDSIVG
ERGRLDSELRN-MQDLVEDLKNK-YEDEINKRTA---AENEFVTLK--K---DVDAAYMN
KVELQAKADTLTDEINFLRALYEA-----ELSQMQTHISDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEEIAQ-RSRAEAESWYQSK--YEELQVTAGRHGDDLRNTKQEIAEIN--
RMIQRLRSE-I--DHVKK------------------------------------------
-----Q-CA--NLQAAIADAEQ-RGEMAL-KDAKNKL----EGLEDALQKAKQDLL----
-----MNVKLALDL--------LEGEECRWTIIALLGRKLKGSLRSHPPCVPLH-RLN-G
EG--VG-QV-------N-ISVVQSTV----------------------------------
------------SSGYGGASG-------------------------V-------------
---------------------------------------GSGLGLGGGSS----YS----
-----------------------YGSG--------------LGVG--------------G
GFSSS---SGRAIG--GGLS--SVGGG-SSTIKYT----TTSS-----------------
------------------------------------------------------------
------------SSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------M--
----SRQVCKT--S--GGRSQGFSGHSAVIS------GSSR-M-SC---VARTRGA-G--
-----GG-------------------------ACGFQ----SG---AGGFGSRSLYNLGG
N-KSISISVAG-GS-RAGGFGGGRS------SCISGFGGGYGGGFGGGFGG---------
-GR--GMGGGFGGAGGFG--------GVGGFGGA-----GGFGGAGGFGGAGGFGGAGGF
GGPGGFGGPG--GFGG---PGGFGP-GG--FPGGI------QEVTVNQSLLQPL----NV
EIDPQIGQ--VKAQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQQQGTNSI--TGTNNL--EPLFE-NYINSQRSYLDSILG
EKGRLDSELRN-MQDLVEDFKKK-YEDEINKRTA---AENEFVTLK--K---DVDAAYMN
KVELQAKVDALRDEINFLTTLYEM-----ELSQMQSHVSDT----SVVLSMDNNRFLDLD
SIIA-EVKAQYEEIAQ-RSKAEAEALYQTK--LGELQTTAGRHGDDLKSTKSEISELN--
RLIQRLRAE-I--ENVKK------------------------------------------
-----Q-SA--KLQTAVADAEQ-RGEMAL-KDANAKL----QELRAALQQAKDDLARLLR
DYQELMNVKLALDVEIATYRKLLEGEE--------------------------S-DR---
-CTVL---S--------PAAVVSSSS----------------------------------
-------TTSASAGGYGGGFGG-------------GIGVGGG------------------
----------------------------------------AGGGFGGAGG--SGLGGG--
SGFGGGSGLGGG------SGFGGGS--GFGG--------------G--SG--F-GGSGGF
GSGSA--GR-CGVSGGGFSSG---SSSRGGSVKFS----QSS------------------
------------------------------------------------------------
----------QRS-SR--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTQKSYK--VST--SGPRTFSSRSYTSGPG-----ARI-SSSSF-------------
-------------------------------------------------------SRVGS
S----------------------------------SFRGG------------LGGGY---
--------------G---------------------------------------------
------------------GASG---------MGGI------TAVTVNQSLLSPL----NL
EVDPNIQA--VRT QEKEQIKTLDNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQQ-QKT-----SRSNT--DNMFE-SYINNLRRQLETLGQ
EKLKLEAELGN-MQGLGGGL-----QEQINKRTE---MENEFVLIK--K-----------
-------------DINFLRQLYEE-----EIRELQSQISDT----SVVLSMDNSRSLDMD
SIIS-EVKAQYEEIAN-RSLAEAESMYQTK--YEELQSLAGKHGGDLRRTKTEISEMN--
RNISRLQAE-I--EGLKG------------------------------------------
-----Q-RA--SLEAAITDAEQ-RGELGI-KDANAKL----SELEAALQRAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEES---------------------------RLE-S
---GM---Q--------NMSIHTKTTSG--------------------------------
---------------SGG---------------------GLSL-----------------
---AYG------------------------------GFTSPGLSYSLG------------
---------------------------------S--------SFGSGA---------GSS
SFSCT-------------------SSSRAMVVKKI------ETCDGKLVSESSDVLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
MA--STSTTIR--SH-SSSRRGFSANSARLPG-----VSRS-GFSSVS-VSRSRGSGGLG
G-------------------------------AC-----------GGAGFGSRSLYGLGG
S-KRISIGGG----SC--AISGG-------------YGS--RA----GGSYGFGG-A-G-
--------------SGFGFG--GG--A------GI-----------------GF----GL
G--GG-AGLAG-GFGGPGFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPTIQR--VRA EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWTLLQEQGTK----TVRQNL--EPLFE-QYINNLRRQLDSIVG
ERGRLDSELRG-MQDLVEDFKNK-YEDEINKRTA---AENEFVTLK--K---DVDAAYMN
KVELQAKADTLTDEINFLRALYDA-----ELSQMQTHISDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEEIAQ-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEIAEIN--
RMIQRLRSE-I--DHVKK------------------------------------------
-----Q-CA--NLQAAIADAEQ-RGEMAL-KDAKNKL----EGLEDALQKAKQDLARLLK
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLN-G
EG--VG-QV-------N-ISVVQSTV----------------------------------
------------SSGYGGASG-------------------------V-------------
---------------------------------------GSGLGLGGGSS----YS----
-----------------------YGSG--------------LGVG--------------G
GFSSS---SGRAIG--GGLS--SVGGG-SSTIKYT----TTSS-----------------
------------------------------------------------------------
------------SSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSR
QFT-----CK----SGAAAKGGFSGCSAVLSGGS------------SS-SFRAG------
------------------------------------------SKGLSGGFGSRSLYSLGG
V-RS--LNVASGSG-KSGGY----------------------------------------
-------------------------------GFGRGRA----------------------
------SGFAGSMFGSVALGPVCPT-VC--PPGGI------HQVTVNESLLAPL----NV
ELDPEIQK--VRA QEREQIKALNNKFASF------IDK--VR------------------
----FLEQQNQ-VLETKWELLQQLDLNN----CKNNL--EPILE-GYISNLRKQLETLSG
DRVRLDSELRN-VRDVVEDYKKR-YEEEINKRTA---AENEFVLLK--K---DVDAAYAN
KVELQAKVESMDQEIKFFRCLFEA-----EITQIQSHISDM----SVILSMDNNRNLDLD
SIID-EVRTQYEEIAL-KSKAEAEALYQTK--FQELQLAAGRHGDDLKNTKNEISELT--
RLIQRIRSE-I--ENVKK------------------------------------------
-----Q-AS--NLETAIADAEQ-RGDNAL-KDARAKL----DELEGALHQAKEELARMLR
EYQELMSLKLALDMEIATYRKLLESEE--------------------------C-RMS-G
EFPS-P--V--------SISIISSTSGGSG------------------------------
------------YGFRPSTVSGG-YV----ANSSNC-----ISGVCSVRGGEGRSRG---
SA--------------------NDYKDTLGKG----------SSLSA-------------
------------------------------------------------------------
----------------------------------P----SKK------------------
------------------------------------------------------------
----------TSR-----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQSSVS--FQ-SGGRRGFSASSAITPN-----VSRT-SFSSVS-MSRAGGG-GGG
GYGRIS--------------------------VG-------GAGG-GGGFGSRSLYNVGM
S-KRISMGGG-----G--GFRSG-------------YGG--RV----GGGYGFGGGA-G-
--------------SGFGIG--GGAGGG-------------------------F----GL
G--GG-GGFGG-GFGGPGFP------VC--PPGGI------QEVTVNQSLLAPL----NL
QIDPTIQR--VKTEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGHK----TVRQNL--EPLFE-TYINNLRRQLENSLA
DRGRLENELRN-MQDAVEDFKNK-YEDEINKRTA---AENDFVMLK--K---DVDGAYMN
KVELEAKADSLNDEVNFLRTLYEM-----ELSQMQVHVSDT----NVVLSMDNNRNLDLN
SIIA-EVKAQYEDIAN-RSRTEAESWYQTK--YEELQQTAGRHGDDLRNTKHEISEMN--
RMIQRLRAE-I--DNVKK------------------------------------------
-----Q-CA--NLQASIADAEQ-RGELAL-KDARAKL----AELEDALQKAKQDMARQLR
EYQELMNVKLSLDIEIATYRKLLEGEE--------------------------C-RLS-G
EG--VG-PV-------S-VSVVTSSV----------------------------------
------------SGGYGGG--G--------------------------------------
----------------------------------------------------------F-
-----------------------GS---------GGG--GGLSVGG-------------S
GFSSG---SGRGMGV--SLG--GGGG-SSSSVKFV----STTS-S---------------
------------------------------------------------------------
-------------SRKSFKS----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------MQAF-LSSHSA------PLQ--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVRQSL--DSLFE-GYISTLRREVDNIFE
ERGRLDSELRS-MQDLVEDNKKK-YEDEINKRTA---AENEFVTLK--K---DVDAAYMN
KVELQAKADGLTDEINFLRAIFEA-----ELSQMQTHISDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEEIAQ-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEIAEIN--
RMIQRLRSE-M--DHVKK------------------------------------------
-----Q-CA--SLQAAIADAEQ-RGEMAL-KDAKSKL----EGLEDALQKAKQDMARLLK
EYQELLNVKLALDVEIATYRKLLEGEECRWHLWEGSG-----------------------
-------P----------EQGIVSTV----------------------------------
------------SSGYGSAGG-------------------------A-------------
---------------------------------------GSGFGLGGGSS----YS----
-----------------------YSSG--------------HGLG--------------G
GFSSG---SGRGIG--GGLS--SSGGS-SSTIKYS----STTS-----------------
------------------------------------------------------------
--------------SRSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQSSVS--FR-SGGSRSFSTASAITPS-----VSRT-SFTSV---SRSGG--GGG
GFGRVS--------------------------LG-------GAYGA-GGYGSRSLYNLGG
S-KRISISTS----GG--SFRNR-------------FGAG--A----GGGYGFGGGA-G-
--------------SGFGFG--GGAG--------G-----------------GF----GL
G--GGA-GFGG-GFGGPGFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPSIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVRQNL--EPLFE-QYINNLRRQLDSIVG
ERGRLDSELRN-MQDLVEDFKNK-YEDEINKRTT---AENEFVMLK--K---DVDAAYMN
KVELEARVDALMDEINFMKMFFDA-----ELSQMQTHVSDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEEIAN-RSRTEAESWYQTK--YEELQQTAGRHGDDLRNTKHEISEMN--
RMIQRLRAE-I--DNVKK------------------------------------------
-----Q-CA--NLQNAIADAEQ-RGELAL-KDARNKL----AELEEALQKAKQDMARLLR
EYQELMNTKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VG-PV-------N-ISVVTSSV----------------------------------
------------SSGYGGGS-G--------------YGG--GLGGGLGGG----------
------------L--------------------------GGGLG-GGSSG----SYYSS-
------------------------SSG-----GVGLG--SGLSVGG-------------S
GFSAS---SGRGLGVGFGS---GG-G-SSSSVKFV----STTS-S---------------
------------------------------------------------------------
-------------SRKSFKS----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTQKSYK--VS-----------HSYKSGPS-----ALI-SFSSF-------------
-------------------------------------------------------SQVGS
-----------------------S-----------SFQCG------------LGG-----
---------------SYG------------------------------------------
-----------------GASS----------MGDI------TTVTVNQSLLSPL----NL
KVDPNIQA--VRT QEKEQIKTLSNKFASF------IDK--VQ------------------
----FLEQQNK-MLETKWSLLQQ-QKR-----AWSNM--DNMFQ-SYINNLRRQLETLDQ
EKLELEAELGI-TQGLVEDFKNK-YKDENNKHIE---MENEFVLIK--K---DVDEAYVN
KLELESPLEGLTDEINFLRQLYEE-----EIRKLLSQIWDM----SVVLSMDNSRFLDMD
SIIA-EVKVQYEE---------AESMYQNK--YEELQTLAGKHGDDLQCTKTEISEMN--
QNISQ-------------------------------------------------------
-------RA--SLEAAIT--------LAI-KDANTKV----SELEGTLQQAKQDLERQLR
EYQKLMNIKLALDIEIATYRNLLQGEEN---------------------------QLE-S
---EM---Q--------NMSIHRKTTSG--------------------------------
------------------------------------------------------------
----YG------------------------------DLTTPSLSYGLG------------
---------------------------------S--------SFGSAA---------GSS
SFSQT-------------------SSTRVMVVKKI------ETRDGKLVSESSDVLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--AMSSKSTIR--TQ-SSSHRGFSASSARVPG-----VSRS-GFSSVS-VCRSRGSGGLG
G-------------------------------VC-----------GGAGFGSRSLYGLGG
S-KRISIGGG----SC--AISGG-------------YGG--RV----GGGFGFGGGA-G-
--------------SGFGFG--GG--S------GG-----------------GF----GL
G--GG-AGFGG-GYGGAGFP------VC--PPGGI------QEVTINQNLLTPL----NL
QIDPTIQR--VRTEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVRQNL--EPLFE-QYINNLRRQLDSIVG
ERGRLDSELRG-MQDMVEDFKSK-YEDEINKRTA---AENEFVTLK--K---DVDAAYMN
KVELQAKVDALMDEINFTRAFYEA-----ELAQMQTHISDT----SVVLSMDNNRDLDLG
SIIA-EVKAQYEEIAQ-RSRTEAESWYQSK--YEELQVTAGRHGDDLRNTKQEIAEIN--
RMIQRLRSE-I--DHVKK------------------------------------------
-----Q-CA--NLQAAIADAEQ-RGELAL-KDAKSKL----VELEDALQKAKQDMARLLK
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VG-PV-------N-ISVVQSTV----------------------------------
------------SSGYGSAGG-------------------------V-------------
---------------------------------------GSGFGLGGGSG----YS----
-----------------------YGSG-----H-SLG--G--------------------
GFSSG---SGRGFG--GGLS--SAGGS-SSTIKYS----TTS--S---------------
------------------------------------------------------------
------------TTRKGYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
----------------------------------------------------------MM
-SSRSRQTYTT--------KGGFSSNSASGG---GGSGART-SFSSVT-VSRSSGSGGG-
--------------------------T--------------RRGPSMGGFGSRSLYNLGG
N-RSISVSVAGAASSG-RGL----------------------------------------
--------------GGFGFG------------------SGAFA-----------------
-------GLG-------AGRQTVGP-VC--PPGGI------QEVTINQSLLTPL----NV
EIDPEIQR--VRTQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQGQNSG--STRRNL--EPLFE-SYLSNLRNVLGKLQN
ERGRLDSELRN-VQDLLEDLKSK-YEDEINKRTG---AENEFVVLK--K---DVDAAYMG
RVDLQGKVDTLTQEIDFLQQIYEM-----ELSQVQTHVSDT----NVVLSMDNNRNLDLD
SIIA-EVKAQYELIAQ-RSRAESEAWYQTK--YEELQVTAGKHGDNLRDTKNEIAELT--
RTIQRLQGE-A--DAAKK------------------------------------------
-----Q-YQ--QLQTAIAEAEQ-HGELAL-KDAKKKL----GDLDVALHQAKEDLARLLR
DYQELMNVKLALDVEIATYRKLLEGEE--------------------------S-RMS-G
ECPST---V--------SISVMGNSTTVSG------------------------------
-----------------GG--------------AAGFGGGISLGGS---GG--ASKGGFG
TS----------------------------------------VGYST----------V--
KGGPASG--GTSILRKT--TTVKTSSRRY-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
----------------------------------------------------------MR
-SSVSQQTYST--------KGGFSSNSASGG---GGSRAHT-SFSSVT-VSQSSGSSGG-
--------------------------A--------------PCGPSAGGLGSRSLYNLGG
S-KSISVSVAGGASSG-RNL----------------------------------------
--------------GGFGLG------------------RGAYV-----------------
-------GLG-------AGRQMFGL-AC--PPGGI------QQVTVNQSLLTPL----NV
EIDPEIRQ--VRT QEREQIKTLNDKFASF------IDK--VR------------------
----FLEQQNK-VLETKWVLLQEQGQKSG--VTRKNL--EPLFE-NYISNLRMQLDSLQS
ERGRLDSELRN-MQDLVEDFKNK-YEDEINKRNA---AENEFVVLK--K---DVDAAFMG
RMDLHGKVDGLTDEINFLRHLYEE-----ELSQMQTHVSDT----NVILSMDNNRNLDLD
SIIA-EVKAQYEQIAQ-RSRAEAEAWYQSK--YEELQVTAGKHGDNLRDTKNEISELT--
RTVQRLQGE-V--DAAKK------------------------------------------
-----Q-CQ--HLQSAIEEAEQ-RGDLAL-KDAQKKL----GDLDMALHQAKEDLARLLR
DYQALMNVKLALDVEIATYRKLLESEE--------------------------S-SGL-S
TLPVG---DSILTQTLCLTAVTGNSTTVYG------------------------------
-----------------GG--------------AAGFGGGISLGGS---GG--ASKGGFS
TN----------------------------------------VGYST----------V--
KGGPVSG--STSILRKT--TTVKTSSRRY-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTQKSYK--VST--SGPRAFSSRSYTSGPG-----SRI-SSSGF-------------
-------------------------------------------------------SRVGS
S----------------------S-----------SFRGG------------VG------
-------------------L----------------------------------------
---------------GGY-GGAG-------GVGGI------TAVQVNQSLLNPL----NL
EVDPNIQA--VRI QEKEQIKNLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQQ-QKT-----SRSNM--DNMFE-SYINNLRRQLDTLGQ
EKLKLEAELGN-MQGMVEDFKNK-YEDEINKRTE---MENEFVLIK--K---DVDEAYMN
KVELESRLEGLTDEINFLRQLYEE-----EIRELQSQISDT----SVVLSMDNSRSLDLD
GIIA-EVKAQYEEIAN-RSRAEAESMYQIK--YEELQTLAGKHGDDLRRTKSEISEMN--
RSISRLQAE-I--EALKG------------------------------------------
-----Q-RA--ALEAAIADAEQ-RGEMAI-KDANAKL----AQLESALQKAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEEN---------------------------RLE-A
---GM---Q--------NLSIHTKTTSG--------------------------------
---------------YAG---------------------VVSS-----------------
---PYG------------------------------GLTSPGFGSLT-------------
---------------------------------------------------------SPG
F---T-------------------RTKSAVVVKKI------ETRDGKLVSETSDVLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSV
R--VTQKSYK--VS--TSGPQAFSSHSYTSGPG-----DHI-SSSSF-------------
-------------------------------------------------------SRVGS
-----------------------S-----------SFRRG------------LGE-----
---------------GYG------------------------------------------
-----------------GASG----------MGGI------TAIT---------------
--------------------TLNNKFASF------VDK----------------------
----------------------Q-EKT-----AQRNM--DNMFE-SYINNLRRQLKTPGQ
EKLKLEAELGN-MQGMVEDFKNK-YEDENNKRAE---VENEI----------DVDEGYMN
KVELESRLEGLPDEINFLKQLYEE-----EIWELQSPISDI----SVVLSMDNNRSLGMN
SIIS-EVKAPYEEIAN-S-----ESMYQIK--YEELQTLAGKHKDDLWCIETEISKMN--
RNISRLQAE-T--EGLKG------------------------------------------
-----H-RA--SLEALIADAEQ-RGELVV-KDANAKL----SELEVSLQRAKQDMAWQLL
EYQELMNVKLALDIEIANYRKLLEGEES---------------------------RLE-S
---GM---Q--------NMIIYTKTTSG--------------------------------
---------------YAG---------------------GLNS-----------------
---TYG------------------------------GLTSP-------------------
------------------------------------------HFGSGV---------GST
SFSCT-------------------STTRAVVVKKI------KTHDGKLVS----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
----------------------------------------------------------MR
-SSVSRQTYST--------KGGFSSSSTCGG---GGPRART-SYSSVT-VSRGSSG--G-
-------------------------------A---------RYGPSMGGFGSRSLYNLGG
S-KSISCSVAGGSSAG-RSL----------------------------------------
--------------GGMGFG------------------SGAFT-----------------
-------GLG-------AGRQFFGP-VC--PPGGI------QEVTVNQSLLTPL----NV
EIDPEIQR--VRTQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQSQNTG--ITRNNL--EPLFE-NYLNTLRRQLDSVQG
ERGRLDAELRN-VQDLVEDFKSK-YEDEITKRTA---AENEFVVLK--K---DVDSAYMG
RMDLHGRVGTLTQEIEFLNHLYEM-----ELSQVQTHVSDT----NVILSMDNNRCXXXX
XXXX-XXXXXXXXXXX-XXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXXXXXXXX--
XXXXXXXXX-X--XXXXX------------------------------------------
-----X-CQ--QLQTAIAKAEQ-RGDLAL-KDAQKKF----GDLDSALHQAKEDLARLLR
DYQALMNVKLALDMEIATYRTLLEGEE--------------------------S-RMS-G
ECPSA---V--------SISVTGNSTTVCG------------------------------
-----------------GG--------------SASFGGGVSLGGA---GG--ASRGGFS
SS----------------------------------------LGYGT----------A--
KGGPTSG--GTSILRKT--TTVKTSSRRY-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTQKSYK--VST--SGPRAFSSCSYTSGPG-----ARI-SSSSF-------------
-------------------------------------------------------SQVGS
S----------------------------------SFRGG------------LGGGY---
------------------------------------------------------------
-------------------GGAS-------GMGGI------TAVTVNQSLLSPL----NL
EVDPNIQA--VRT QEKEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQQ-QKT-----ARSNM--DNMFE-SYINNLRRQLETLGQ
EKLKLEAELGN-MQGLVEDFKNK-YEDEINKRTE---MENEFVLIK--K---DVDEAYMN
K-------------INFLRQLYEE-----EIRELQSQISDT----SVVLSMDNSRSLDMD
SIIA-EVKAQYEEIAN-RSRAKAESMYQIK--YEELQSLAGKHGDDLRRTKTEISEMN--
RNISRLQAE-I--EGLKG------------------------------------------
-----Q-RA--SLEAAIADAEQ-RGELAI-KDANAKL----SELEAALQRAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEES---------------------------RLE-S
---GM---Q--------NMSIHTKTTSG--------------------------------
---------------YAG---------------------GLSS-----------------
---AYG------------------------------GLTSPGLSYGLG------------
--------------------------------SS---------FGSGA---------GSS
SFSRT-------------------SSSRAVVVKKI------ETRDGKLVSESSDVLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTQKSYQ--VS--TYGPQAFSSRSYTSAPG-----AHI-SSSSF-------------
-------------------------------------------------------SWVGN
S----------------------S-----------SFRGK------------PG------
------------------------------------------------------------
-----------------YQHG----------VGGI------TAVTVNQNLRSPL----KL
EVDPNTHA--VCI QEKEQIKSLN-KFDSF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQQ-QKT-----SRSNM--DNMFE-SYINNLRRQLEALGQ
EKLKWEAELGN-MQGLVEDFKTK-YEDEINKCTE---LENDFVLIK--K---DVDEAYMN
KVELESRLEGLTDKINLLRLIHEE-----EIRELQSQISDT----SVVLSMDNSHSLDMD
SIIA-EVRAQYEDIAN-CSPAEAESMYQIK--YEELQTLTGKHGDDLCCTKTEISEMN--
RNISRLQAE-I--EGLKG------------------------------------------
-----P-KA--MLEAAIADAEQ-RGEMAI-KVANAKL----AQLETALQ---QDMARQLR
EYQELMNVKLALDI----YRKLLEGEES---------------------------RLE-S
---RM---Q--------NLSTHTKTTSG--------------------------------
---------------YSG---------------------GLSS-----------------
---AYG------------------------------GFTSPGFSYGMS--------SF--
--------------------------------QP--------GFSSVG---------GSS
TYSH----------------------TKAVVVKKI------ETRDGKLVSESSDILPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSM
R--VTQKTYK--VST--SGPRAFSSLSYTSGPG-----SRV-SSSSF-------------
-------------------------------------------------------SRVGS
S---------------------GS-----------SFRGG------------LG------
-------------------L----------------------------------------
---------------GGY-GGAA-------GMGGI------TAVQVNQSLLNPL----NL
EVDPNIQA--VRL QEKEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQQ-QKT-----SRSNM--DNMFE-SYINNLRRQLDTLGQ
EKLKLEAELGN-MQGLVEDFKNK-YEDEINKRTE---MENEFVLIK--K---DVDEAYMN
KVELESRLEGLTDEINFLRQLYEE-----EIRELQSQISDT----SVVLSMDNSRSLDLD
GIIA-EVKAQYEEIAN-RSRAEAESMYQIK--YEELQTLAGKHGDDLRRTKSEISDMN--
RSISRLQGE-I--EALKG------------------------------------------
-----Q-RA--SLEAAIADAEQ-RGELAI-KDANAKL----AQLESALQKAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEEN---------------------------RLE-A
---GM---Q--------NMSIHTKTTSG--------------------------------
---------------YSG---------------------MVSS-----------------
---PYG------------------------------GLPSPGFGSLQ-------------
---------------------------------------------------------SPG
F---T-------------------RTKSAVVVKKI------ETRDGKLVSETSDVLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
-------------------------------------------------LSSSFS-SVFM
KASMSRQAYST--------KGGFSSSSASGGHGMGGTQTHT-SFSSMT-MSRGGSRLGG-
--------------------------A--------------AYCSPRGSFGSHSHHNLGA
N-TRISVSMAQGASHG-RSF----------------------------------------
--------------GGFGVG------------------AGSYL-----------------
-------GLG-------SSRPNFGA-SC--PPGGI------QEVTVNQSLLTPL----NV
EIDPEIQR--VRTQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQSQNTV--AT-KDL--EPYFE-TYICNLRRQLDALQN
EAGRLDLELNN-IHDHVDNQKHS-YEEEFNKRTV---AENEFVTLK--K---DVDAEYMN
CANLEAISKSMLEEFNFLQNLFAM-----ERSQFQTHVSDT----NVVLSMDNNRCLDLD
SIIA-EVKTQYEEIAK-RSRAEAESWYQTK--YEELQVTAGKHEDHLRDTKKEISELT--
RTVQRLQGE-I--DSVKK------------------------------------------
-----Q-CQ--QLQTAIADAEQ-CGELAI-KDAKKKL----GDMETALHHTKEELAKLLR
DYQELMNVKLALDMEIATYKKLLECEE--------------------------S-RMS-G
ECPSA---I--------SISVMGNSTSMCG------------------------------
-----------------GNIRGV---------GSSRAGVS--LGSS---CG--GMKGSYG
SS----------------------------------------CSY------------A--
KPGPNTG--GTSILKKTTSTTVKSSTRRY-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--M-SRQSTIT--FHT-GSRRGFSTASATTAN-----TGRS-RFSSAS-VARSSG--NSG
ALGRIS--------------------------GA------------GTGFGSRSLYNLGG
S-KRVSVGGSAGSG-----FRIG-------------FGG--RA----STGFGV-----S-
--------------SGFGYG--GGIGGGY-------------------------------
--------------GGAGFP------VC--PSGGI------QEVTVNQSLLTPL----NL
QIDPTIQR--VRK EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWSLLQEQGSR----TVRHNL--EPLFD-TYINDLRRQLDGITA
ERGRLDAELRN-TQEVVEDFKVR-YEDEINKRTA---AENEFVTLK--K---DVDGAYMN
KVELEAKVDSLTDQLNFYRMIYEA-----ELSQMQNQVSDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEDIAN-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEISEMN--
RMIQRLRSE-I--DGVKK------------------------------------------
-----Q-CA--SLQTAISDAEQ-RGELAL-KDARAKL----VDLEDALQKAKQDMARLLR
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------Y-RLS-A
EG--VS-PVNIS--------VVTSTV----------------------------------
------------SSGYGGGS--GLG-----------------------------------
---------------------------------------SGSLGLNGSSG----YNFTT-
-----------------------SS-------GHSLG--A--GLGG-------------S
SFTTC---SSRGPGS------------SGSSIKFV----STTS-----------------
------------------------------------------------------------
------------SSRKSYRH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQACKK--SF-SGGSQGFSGRSAMVSSS-----S-----------SSSGGA-S--
-----GG-------------------------ACGLQ----SG---AGGFRSRSLYNLGG
N-KSISMSVAAGGS-QAGGFGGGHS------SCGSGFGGVYRGGFGSGRG----------
------MGG-------------------------------------------GFGGAG--
------------GFGG---SAGFVA-VC--PPGGI------QEVTVNQSLLQPL----NV
EIDPQMGQ--VKAQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWELLQQQATRSG--SGPKNL--EPFFE-SYISFLHKWLDSLLG
ERENLEGE--------------------------------------------DVDAAYVN
KAELQAKVDSLVDEINFLRTLYDM-----ELSQMQNHVSNM----SVVVSMDNNRCLDLD
SIIA-EVRAQYEEIAQ-RSKAEVEALYQTK--LGELQTTAGRHGDDLRSTKNEIMELN--
MMTQRLRAE-I--ENVKK------------------------------------------
-----Q-NA--NLQTSIAEAEQ-RGEMVL-KDANAKL----QDLQSALQQAKDDLAHLLH
DYQGLMNIKLALDVEIATYRKLLEGEE--------------------------Y-SSS-G
G-----------------------------------------------------------
-------------------FRGVNGS----SS--SGYRGGSSSVG---------I-----
--------------RGSSGSSY------------------------GQDS--SSRRSG--
GR---------SSS---------SSGSSSSSSSS------GTRLGSGGSR--CV-SQRGA
GFGSA--CI-QTSV--GYKS----ACGGNSSRHFS----QIT------------------
------------------------------------------------------------
----------TSSSQQCPK-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
-------------------------------MT------QRSS---VTIKSGGTRNF---
-------------------SASSASLLPGCRPG----FSSV-SVSQS----G--------
---------------------------------------KSFGGGIGGGFGTRSLHSFGG
N-KRISIGGGYRST-R-ASFGGAAC-----------------------------------
---------------GLGVS-------GIGYRVGG-------------------------
------------AYGGYGYGGGMAP-----GAGGI------HEVTVNQSLLTPL----HL
EIDPSLQR--VRK EEKEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWSLLQEHKTT-----RT-NL--EPMFE-AYITNLRRQLECLGG
ERSRLETELKS-MQDVVEDFKNK-YEEEIHRRTA---AENEFVVLK--K---DVDAAYMN
KVELEAKVEALMDEINFLRAFFEA-----ELAQLQAQISET----SVVLSMDNNRSLNLD
SIIA-EVKAQYEDIAN-RSRAEAESWYQTK--YEELQRSAGQRGDDLRTTKMEISELN--
RAMQRLRSE-I--DNLKK------------------------------------------
-----Q-CA--TLQASIADAEQ-RGELAL-KDAKNKL----AELEDALQKAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEE--------------------------C-RLT-G
EGVGA---V--------NISVVSSSGGTGYSGGG--------------------------
-G----LC-VSGG-GYS-------------------GGGYSGSGLCYGGGG----SGGFS
STSGR-SVSGSS------------------------------------------------
--------SSMRIVSKTSSTKKSYRS----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------M--
----SRQASKI--S--SGGSQGFSGRSAVVSG------SSR-M-SS---VACAGGA-G--
-----GG-------------------------ACGFR----SG---AGGFGSRSLYNLGG
N-KSISISVAAGGS-RAGGFGGGRS------S--YGFGGGYGGGFGGGYGGGFGGGFGGG
--R--GIGGGFGGAGGFG--------GAGGFGGA-----GGFGGAGGFGGPGGFGGPGSF
GGPGGF---------G---P------GG--FPGGI------QEVTVNQSLLQPL----NV
EIDPQIGQ--VKAQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQQQGTSSI--SGTNNL--EPLFE-NHINYLRSYLDNILG
ERGRLDSELRN-MQDLVEDFKKK-YEDEINKRTV---AENEFVTLK--K---DVDTAYMN
KVELQAKVDALLDEIDFLRTLYNA-----ELSQMQSHISDT----SVVLSMDNNRSLDLD
SIIA-EVRAQYEDIAQ-RSKAEAEALYQTK--LGELQTTAGRHGDDLRNTKSEIIELN--
RMIQKLRAE-I--ENVKK------------------------------------------
-----Q-NA--NLQTAIAEAEQ-RGEMAL-KDANAKL----QELQAALQQAKDDLARLLR
DYQELMNVKLALDVEIATYRKLLEGEE--------------------------Y-RMS-G
ECPSA---V--------SISVVSSSSSS--------------------------------
-------ATSASAGGYG----G-------------GYGGGLGGGF---------------
--------------------GA----GGG-----------AGSGFGRGGS--GGIGG---
---GFGFGG--------------GGSS--------------------SSG--F-SGGSGF
GSGSG--TR-YGVSGGGFSS----TSNRSGSIKLS----QSS------------------
------------------------------------------------------------
----------Q----RYSR-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQACKK--SF-SCGSQGFSGHSAVVSG------SSR-S-SC---VARSGAA-S--
-----GG-------------------------ACGFR----SG---AGSLGSHSLYSLGG
S-KSISISVAAGGS-RAGGFSGGRS------SCGSGFGSGYGGSLGGSRG----------
------MGA-------------------------------------------GFGGPSGF
GGAG--------GFGR---PGSFGP-GS--CPGGI------QEVTINQSLLQPL----NV
EIDPQIGQ--VKA QEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWELLQQQTIRSG--SGPQNL--EPFFE-SYISCLRKQLDSLLG
AKGSLEGELKS-MQDLVEDFKKK-YEEEINRRTA---AENEFVGLK--K---DVDGAFMN
KVELQAKVDSLTDEINFLRTLYDM-----ELSQIQSHVSDT----SVVLSMDNNRCLDLD
SIIA-EVKAQYEDIAQ-KSKAEAEALYQTK--LGELQTTAGRHGDDLRSTKSEIMDLN--
RMIQRLRAE-I--ENVKK------------------------------------------
-----Q-NT--NMQTSIAEAEQ-RGERAL-KDADTKF----QDLQVALQKAKEDMARLLK
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EFQNA---V--------SISVVSNVTS---------------------------------
--------TS-S----SGSFRGTGGS----NY--G----GD-------------------
----------------SSGRSG------------------------GSSS--S-------
-----------S------------SRGSSSRGSS------GSRLGSGGSI--SV-SQQRM
GFNSG--GS-QTSVGSSYKS----GRGGSSSVQFS----QTT------------------
------------------------------------------------------------
----------SSS-QQRSK-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRISYR---ASTGGGSRGFTSGSAIVGGGGGGGGGRS-SFSSYS-VSRVGGGRA--
-------------------------------------GGGGGGYGLGGGFGSRSLYNIGG
N-KRISYSTIGGGY-RSG-FGGGGG-----------F--GAGGG-----G--YGAGGGG-
-------YGAGGGAGGFGFGVGLGG-GGGGLGFGGPG----YG---G--P----GAGFVV
GGP---------GFS--GRGGPGFP-VC--PPGGI------QEVTINQHLLQPL----KL
EIDPEIQR--VRTNEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWDLLQQQGTTC----QQSTM--EPLFD-VYITNLRRQLEALTN
ERGRLDSELRN-MQDMVEDYKNK-YEDEINKRTG---SENEFVVLK--K---DVDGAYMN
KIELAGKFESLNDEIEFLKAMYDA-----ELSQMQQHVSDT----SVVLSMDNNRCLDLN
SIIA-EVKAQYEDIAQ-RSRTEAESWYQTK--YEELQVSAGRHGDDLRNTKTEISELN--
RMIQRLRSE-I--DSFKK------------------------------------------
-----Q-CA--NLQAAIAEAED-RGEMAL-KDAKHKL----SELEEALQRTKQDLARQLK
EYQELMNVKLALDIEIATYKKLLEGEE--------------------------I-RLA--
EGVG-N--V--------GYTVVSSSTSTGY------------------------------
------------GGSG---LALG-----------------GGG------GGGHGFGGGFG
GGS----------------------------G----GGYGGGSGYGLGGG-GSSYSIGG-
-------------------------GSGF-GGGS------GFGSGVSLG--------GGS
GYSSG--GG-R-----VSSGGG----GGSSSVKIV----SKT------------------
------------------------------------------------------------
----------TST-KKMAY-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--M-SRQSSVT--FQTS-SRRGFSTASATTPA-----AGRS-RFSSVS-VAHSTG--GSG
GLGRIG--------------------------ST------------GAGFGSRSLYNLGG
T-KRVSIGAC-SSG-----FRSG-------------FGS--RA----SGGFGV-----N-
--------------SGFGYG--SGVGGGF-------------------------------
--------------GGPGFP------VC--LSGGI------PEVTINQSLLTPL----NL
QIDPTIQR--VRK EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWTLLQEQGSR----TVRQNL--EPFFD-TYISDLRRQLDSITT
ERGRLEAELRN-MQDVVEDFKVR-YEDEINKRTA---AENEFVALK--K---DVDGAYMN
KVELETKVKSLADETNFLHLVFEA-----ELSQMQTQVSDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEDIAN-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEISEMN--
RMIQRLRAE-I--DGVKK------------------------------------------
-----Q-CS--SLQTAIADAEQ-RGELAL-KDARAKL----VDLEDALQKAKQDMARLLR
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VS-PVNIS--------VVTNTV----------------------------------
------------SNGYGGGS--GIG-----------------------------------
---------------------------------------GGSLGLGGGSG----YSLTT-
-----------------------SG-------GHSL--------GG-------------S
GFSAS---SSRGLGG------------SGSSIKFV----SXXX-----------------
------------------------------------------------------------
------------XXXXXXXH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQSTVS--FR-SGGSRSFSTASAITPS-----VSRT-SFTSV---SRSGGG-GGG
GFGRVS--------------------------LG-------GAYGA-GGFGSRSLYNLGG
S-KRISISAS----GG--GFRNR-------------FGAG--A----GGGYGFGGGA-G-
--------------SGFGFG--GGAGG-------G-----------------GF----GL
G--GGA-GFGG-GFGGPGFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPTIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVRQNL--EPLFE-QYINNLRRQLDGILG
ERGRLDSELRN-MQDLVEDFKNK-YEDEINKRTT---AENEFVMLK--K---DVDAAYMN
KVELEAK-------INFMKMFFDA-----ELSQMQTHVSDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEDIAN-RSRTEAESWYQTK--YEELQQTAGRHGDDLRNTKHEISEMN--
RMIQRLRSE-I--DNVKK------------------------------------------
-----Q-CA--NLQNAIADAEQ-RGELAL-KDARNKL----AELEDALQKAKQDMARLLR
EYQELMNTKLALDVEIATYRKLLEGEE--------------------------C-RWV-T
RL--------------------TSQI----------------------------------
------------HSGLTFDK-V--------------WGG---------------------
-----------------------------------------GLG-GGGSS----SFYS--
-----------------------SSSG-----GVGLG--SGLGVGG-------------S
GFSAS---SGRS--LGFGS---GG-G-SSSSVKFV----STTS-S---------------
------------------------------------------------------------
-------------SRKSFKS----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
----------------------------------------------------------MR
-SSRSRQTYAT--------KGGFSSSSASGG---GGSRTHT-SFSSVT-MSRSSGSGGG-
--------------------------V--------------RCGPSTGSFGSRSLYNLGG
S-KSISVSVA---SSG-RAL----------------------------------------
--------------GGFGHS------------------SGAYG-----------------
-------SLG-------AGRQTFGP-VC--PPGGI------QEVTINQSLLTPL----NV
EIDPEIQR--VRTQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQGQNMG--VTRNNP--EPLFE-AYLSNLRRKLDSLLG
ERGRLDAELRN-VQDGLEDFKNK-YEDEINKRTA---LENEFVVLK--K---DVDAAYMG
KMDLHGKVDALVQEVDFLQQLYET-----ERSQVQTHVSDT----NVILSMDNNRSLDLD
SVIA-EVKAQYELIAQ-RSRAEAEAWYQTK--YEELQVTAGKHGDNLRDTKNEISELT--
RTIQRLQSE-V--DAAKK------------------------------------------
-----Q-CQ--QLQAAIGEAEE-RGELAL-KDAKKKL----GDLDTALHQAKEDLARLLR
DYQALMNVKLALDVEIATYRKLLEGEE--------------------------S-RMS-G
ECPSA---V--------SISVTGNSTTVYG------------------------------
-----------------GG--------------SAGFGGGISLGGS---GG--ASKGGFN
TN----------------------------------------VSYST----------V--
KGGPVSG--GTSILRKT--TTVKTSSQRY-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
--------------------IAL-----------------------------LR------
--------------------AHVSAAPAAQPS-----VRRA-DCCQV---VDSLCPT--D
GPDPLS--------------------------WQ-------GSMNQAGTVGHVTDF----
--VRISSN----------------------------------------------------
-----------------------RATHS------------------------VL----LS
S--DLASTSPL-GYGGAGFP------VC--PPGGI------QEVTINQNLLTPL----NL
QIDPTIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVRQNL--EPMFE-QYISNLRRQLDGVLG
ERGRLDSELRN-MQDLVEDFKNK-YEDEINKRTT---AENEFVMLK--K---DVDAAYMN
KVELEAKVDALMDEINFMKMFFDA-----ELSQMQTHVSDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEDIAN-RSRTEAESWYQTK--YEELQQTAGRHGDDLRNTKHEISEMN--
RMIQRLRSE-I--DNVKK------------------------------------------
-----Q-CA--NLQNAIADAEQ-RGELAL-KDARNKL----TELEEALQKAKQDMARLLR
EYQELMNTKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VG-PV-------N-ISVVTNSV----------------------------------
------------SSGYGGGS-LGFGG----G---SSFGGGSGFGGGLGSG----L-----
-----G----------------------------------------GGGG----GSYYS-
-----------------------SSSG-----GAGLG--GGLSVGG-------------S
GFSAS---SGRGM--GFGS----GGG-SSSSVKFV----STTS-S---------------
------------------------------------------------------------
-------------SRRSFKS----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
-AIMSSQSTVR--IQ-RSGRSGFSANSAIIPG-----ITRS-GFSSVS-VSRSGGSGGFG
R-------------------------------AC-------GIS-GGAGFGSRSLYNVGR
S-KRISFAGN----NY--GFQSG-------------YSG--RV----GGGYGFGSG----
--------------------------V------SG-----------------GF----GF
G--GG-AGFGG-GYGGAGFP------VC--PPGGI------QEVTINQSLLTPL----NL
QIDPTIQR--VKSEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVKQSL--DPLFE-SYINQLRGQLDRITR
EKGSLDAELRN-MQDQVEDFKNK-FEDEINKRTA---AENEFVTLK--K---DVDAAYMN
KVELQANADNLLEEINFLKVLYDA-----ELSQMQTHISDT----SVVLSMDNNRTLDLN
SIIA-EVKAQYEDIAQ-KSRAEAESWYQTK--YEELQITAGRHGDDLRNTKHEISEIN--
RMIQRLRSE-I--DNVKK------------------------------------------
-----Q-CA--NLQNAIAEAEQ-KGEMAL-KDARVKL----EELEAALQRAKQDMARQLR
EYQELMNVKLSLDIEIATYRKLLEGEE--------------------------C-RMS-G
EG--VG-PV-------N-ISVVSSTV----------------------------------
------------SSGYGSGSG-----------------------SGV-------------
---------------------------------------GSGFGLGGGSG----YS----
-----------------------YSS--------------GLSVG--------------G
GFSSG---SGR--------G--T-GSS-STSIKYT----TTT--S---------------
------------------------------------------------------------
------------SSKKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
-------------------------------------------------------MLELT
T-------------P---STQVFSSSSAALPRR----SAQV-RLNAG----RPGG-----
----------------------------------------------FA--SSRSLYNLG-
------------TS-RPRVPV--GS-----------------------------------
---------------VYG------------------------------------------
----------------G-------P-----VGAGF------REVTINQNLLAPM----RS
NIDPAIRQ--VRQEEREQIKTLNNKFASF------IDK--VQ------------------
----FLEQQNK-MLETKWALLQEQKSA-----KSSSL--PRIFE-AQIAGLRGQLEKLQL
DRGRLEAELRS-IQDVVEDFKNK-YEEEMNHRMA---AENEFVMLK--K---DVDTAFMN
KVDLQAKVDGLSDEINFLKTLHET-----ELAELQSQISDT----SVVLSMDNNRSLDMD
SIIA-EVKAQYEEMAN-RSRAEAEALYQKK--FEILQAQSGKHGEDLRNTRNEIVEMN--
RAIQRLQAE-I--DNVKN------------------------------------------
-----Q-RA--RLEAAIAEAEE-RGELAL-QDAHGKQ----RELEAALQQAKQDMARQLR
EYQELMNIKLALDIEIATYRKLLEGEE--------------------------S-RLA-R
DGVGA---A--------NISV---------------------------------------
----VNSS-G---------G----------------AGIGLVFGG-----TMGSNALRFS
S------GIPGA------------------------------------------------
--------VKAYSIRTTSTTRESTHH----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
----------------------------------------------------------MR
-SSVSRQTYST--------KGGFSSNSASGG---GGSQART-SFSSVT-VSRNSGSGGG-
--------------------------T--------------RCGPSTGGFGSRSLYNLGG
H-KSISVSVARGASLG-RAL----------------------------------------
--------------GSFGFG------------------SRAFT-----------------
-------GQG-------AGRQTFGP-AC--PPGGI------QEVTVNQSLLTPL----HV
EIDPEIQR--VRTQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQGQNLG--VTRNNL--EPLFE-AYLGSMRSTLDRLQS
ERGRLDSELRN-VQDLVEDFKNK-YEDEINKRTA---AENEFVVLK--K---DVDAAYMG
RMDLHGKVGTLTQEIDFLQQLYEM-----ELSQVQTHVCDT----NVVLSMDNNRNLDLD
SIIA-EVKAQYELIAQ-RSRAEAEAWYQTK--YEELQVTAGKHGDNLRDTKNEIAELT--
RTIQRLQGE-V--DAAKK------------------------------------------
-----Q-CQ--QLQTAIEEAEQ-HGELAL-KDAQKKL----GDLDVALHQAKEDLARLLR
DYQELMNVKLALDVEIATYRKLLESEE--------------------------S-RMS-G
ECPSA---V--------SISVTGNSTTVCG------------------------------
-----------------G---------------------GISLGGN---GG--ATKAGFS
TN----------------------------------------VGYST----------V--
KGGLVSG--GTSILRKT--TTVKTSSRRY-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQSTVT--FQTG-SRRGFSAASATTPT-----AGRS-RFSSVS-MVRSSG--GHG
GLGRIS--------------------------GV------------GTGFGSRSLYNLDG
S-KRISVSGS----NS--GFRSG-------------FGG--RV-----GGYGFGSSI-G-
--------------SGLGFG--AGVGGGY-------------------------------
--------------GGAGFP------VC--PPGGI------QEVTVNQSLLAPL----NL
QIDPTIQR--VRKEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWSILQDH--K----TTKANI--EPLFE-TYINNLRRQLESLGG
ERARLETELKS-MQDVVEDFKNK-YEDEINRRTA---AENEFVVLK--K---DVDAAYMN
KVELEAKADALTDEINFLRAFYEA-----ELAQLQAQISET----SVVLSMDNNRKLDLD
SIIA-EVKAQYEDIAN-RSRAEAESWYQSK--YEELQLSAGRHGDDLRTTRMEISELN--
RMIQRLRSE-I--DNLKK------------------------------------------
-----Q-CA--TLQAAIADAEQ-RGELAL-KDARAKL----AELEDALQKAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEE--------------------------C-RLT-G
EG--VG-PVNIS--------VVTSSG----------------------------------
------------GTGYGGNSGLCVG-----------------------------------
---------------------------------------GGGLSSS--------------
-----------------------------------LC--Y--GSGV-------------G
GFSST---SGRSIGG------------SSSSMRII----SKTS-----------------
------------------------------------------------------------
------------STKKSYRS----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--M-SRQSTIT--FH-SGSRRGFSTASATTPT-----AGRS-RFSSVS-VARSSG--NSG
GLGRIS--------------------------GI------------GSGFGSRSLYNLGG
T-RRVSIGGCAGSG-----FRGG-------------FGG--RT----SSGFGG-----S-
--------------SGFAYG--GGIGGGF-------------------------------
--------------GGPGFS------VC--PSGGI------QEVTVNQSLLTPL----NL
QIDPTIQR--VRK EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQEQGSR----TVRQNL--EPFFD-TYVNDLRRQLDGITA
ERGRLDAELRN-MQEVVEDFKVR-YEDEINKRAA---AENEFVGLK--K---DVDSAYMN
KVELEAKVDSLTDQINFYRMIYEA-----ELSQMQNQVSDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEDIAN-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEISEMN--
RMIQRLRSE-I--DAVKK------------------------------------------
-----Q-CS--SLQTAISDAEQ-RGELAL-KDARAKL----MELEDALQKAKQDMARLLR
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VS-PVNIS--------VVTSTV----------------------------------
------------SSGYGGGA--NIG-----------------------------------
---------------------------------------GGSLGLGGNSG----YSFTT-
-----------------------SG-------GHSLG--T--GLGG-------------S
GFTTT---SSRGPVG------------SGSSIKFV----SSTS-----------------
------------------------------------------------------------
-------------SRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQSSVS--FR-SGGNRSFSTASAITPS-----VSRT-SFTSV---SRSGGGGGGG
GFGRVS--------------------------LG-------GAYG-TGGYGSRSLYNLGG
S-KRISISSS----GG--GFRNR-------------G-CATGA----GGGYGFGGGA-G-
--------------GGFGFG--GGAGGG-------------------------F----GL
S--GG-AGFGG-GYGGSGFS------VC--PPGGI------QEVTINQSLLTPL----NL
QIDPNIQR--VRTEEREQIKTLNNRFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQGTK----TVRQNL--EPLFE-QYTNNLRRQLDGILG
ERGRLDSELRN-MQDLVEDFKNK-YEDEINKRTT---AENEFVMLK--K---DVDAAYMN
KVELEAKVEALMDEINFLKMFFEA-----ELSQIQTHISDT----SVVLSMDNNRCLDLD
SIIA-EVKAQYEEIAN-RSRTEAESWYQTK--XXXXXXXXXXXXXXXXXXXXXXXXXX--
XXXXXXRSD-I--DNVKK------------------------------------------
-----Q-CS--NLQNAVADAEQ-RGELAL-KDARNKL----SGLEDALQKAKQDMARLLK
DYQELMNTKLALDVEIATYRKLLEGEE--------------------------C-RLS-E
G---IG-PV-------N-ISFVTNTV----------------------------------
------------SSAYGGGGS---------------FGS--GLDGGLGGG----L-----
-----GGRSSG---------------------------------------------FYS-
-----------------------SSSG-----GAGLG--SG-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
MA--STSTTIR--SH-SSSRRGFSANSARLPG-----VSRS-GFSSVS-VSRSRGSGGLG
G-------------------------------AC-----------GGAGFGSRSLYGLGG
S-KRISIGGG----SC--AISGG-------------YGS--RA----GGSYGFGG-T-G-
--------------SGFGFG--GG--A------GI-----------------GF----GL
G--GG-AGLAG-GFGGPGFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPTIQR--VRA EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVRQNL--EPLFE-QYINNLRRQLDSIVG
ERGRLDSELRN-MQDLVEDLKNK-YEDEINKRTA---AENEFVTLK--K---DVDAAYMN
KVELQAKADTLTDEINFLRALYDA-----ELSQMQTHISDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEEIAQ-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEIAEIN--
RMIQRLRSE-I--DHVKK------------------------------------------
-----Q-CA--NLQAAIADAEQ-RGEMAL-KDAKNKL----EGLEDALQKAKQDLARLLK
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLN-G
EG--VG-QV-------N-ISVVQSTV----------------------------------
------------SSGYGGASG-------------------------V-------------
---------------------------------------GSGLGLGGGSS----YS----
-----------------------YGSG--------------LGVG--------------G
GFSSS---SGRAIG--GGLS--SVGGG-SSTIKYT----TTSS-----------------
------------------------------------------------------------
------------SSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQSSVS--FR-SGGSRSFSAASAITPS-----VSRT-SFSSV---SRSGG----G
GGGRIS--------------------------LG-------GA-CGAGGYGSRSLYNVGG
S-KRISYSSG----GG--SFRNQ-------------FGAGG---------FGFGGGA-G-
--------------SGFGFG--GGAG-S------------------------GF----GF
G--GGAGFG-G-GYGGAGFP------VC--PPGGI------QEVTVNQNLLTPL----NL
QIDPTIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWALLQEQGTK----TIKQNL--DPLFE-QYINNLRRQLDGVLG
ERGRLDSELRN-MQDLVEDYKNK-YEDEINKRTT---AENEFVMLK--K---DVDAAYMN
KVELEARVDALMDEINFMKMFFDA-----ELSQMQTHVSDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEDIAN-RSRTEAESWYQTK--YEELQQTAGRHGDDLRNTKHEISEMN--
RMIQRLRSE-I--DNVKK------------------------------------------
-----Q-CA--NLQNAIAEAEQ-RGELAL-KDARNKL----TELEEALQKAKQDMARLLR
EYQELMNTKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VG-PV-------N-ISVVTNSV----------------------------------
------------SSGYGGGS-S---I----G---VGSGFGGG----LGSG----F-----
-----A----------------------------------------GGL-----GPRFT-
-----------------------RGGG-----GLGLG--SGLSVGG-------------S
GFSAG---SSQG-GMSFGS----GGG-SGSSVKFV----STTS-S---------------
------------------------------------------------------------
-------------SRRSFKS----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MTSRSTVR--SQ-SGSRRVFSAGSARVPG-----VNRS-GFSSMS-VCRSRGSGGFT
G-------------------------------VG-----------GGASFGSRSLYGIGG
T-KRISLGGG----SC--ALGGG-------------YGG--RA----GGGLGFGVGA-G-
--------------SGFGFG--SA--V------IG-----------------L-------
---GG-AGVAL-GSGGSGFS------IC--PPGGI------QEVTINQS-LTPL----NL
QIDPTIQR--IKTEEREQIKTLNNRFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQGTK----TVRQSL--EPYFE-QYINNLRRQLDYLVS
ERSRLDSELRG-MQDTVEDFKKK-YEDEINKRTS---AENEFVNLK--K---DVDVAYMT
KVDLQANADALIDEINFLRALYEA-----ELAQMQTHVSDT----SVVLSMDNNRTLDLD
SIIA-EVKAQYEEIAR-RSREEAESWYKCK--YEELQSSACRYGDDLCNTKQEIAEIN--
RMIQRLRSE-I--EHVKK------------------------------------------
-----Q-CT--SLQSAIADAEQ-RGELAL-RDAKNKL----AELENALQKAKQDMAQLLK
DYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLY-G
EG--AG-QV-------N-ISVVQSTT----------------------------------
------------SSGYGSAGG-------------------------V-------------
---------------------------------------SSGLGMGGGSG----YS----
-----------------------YSSG------LSVG--G--------------------
GFSSS---SGRAIG--GGLS--SSGGS-SSTVKFS----TTS--S---------------
------------------------------------------------------------
------------SGRKSYRP----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------MSIHFSSRSTAYPGR----GAQV-RLSSG----RA-G-----
----------------------------------------------FGS---RSLYGLG-
------------TS-RPRVAV--RS-----------------------------------
---------------AYG------------------------------------------
----------------G-------P-----VGAGI------REITINQSLLAPL----SV
DIDPTIQQ--VRQ EEHEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWALLQEQKSA-----KSSQL--PRIFE-AQIAGLRQQLETLQL
DGGRLEVELRN-IQDVVEDFKNK-YEEEINRRTA---AENEFVLLK--K---DVDAAYTN
KVELEAKADSLQDEINFLKTLHET-----ELAELQSQISDT----SVVLSMDNSRSLDLD
GIIA-DVKAQYEEMAN-HSRAEAEAWYQTK--FETLQAQAGKHGDDLRNTRNEIAEMN--
RTIQRLQAE-I--DTLKN------------------------------------------
-----Q-RA--KLESSIAEAEE-QGELAL-KDAHAKQ----GELEAALQRAKQDMARQLR
EYQELLNTKLALDIEIATYRKLLEGEE--------------------------S-RLS-G
DGMGP---V--------NISV---------------------------------------
----VNS----------TGA----------------NGSKLIFGG-----TMGSNALSF-
-S-----GGPGA------------------------------------------------
--------LRAYSIKTTST-RRGTHN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MTSRSTVR--SQ-SGSRRVFSAGSARVPG-----VNRS-GFSSMS-VCRSRGSGGFT
G-------------------------------VG-----------GGASFGSRSLYGIGG
S-KRISLGGG----SC--AFGGG-------------YGG--RA----GGGLGFGVGA-G-
--------------SGFGFG--GG--A------DG-----------------GF----GL
G--GG-AGFGG-GYGGSGFS------IC--PPGGI------QEVTINQSLLTPL----NL
QIDPTIQR--IKTEEREQIKTLNNRFASF------IDK--VR------------------
----FLEQQNK-VLETKWVLLQEQGTK----TVRQSL--EPYFE-QYINNLRRQLDCLVS
ERSRLDSELRG-MQDTVEDFKKK-YEDEINKRTS---AENEFVNLK--K---DVDVAYMT
KVDLQANADALIDEINFLRALYEA-----ELAQMQTHVSDT----SVVLSMDNNRTLDLD
SIIA-EVKAQYEEIAR-RSREEAESWYKCK--YEELQSSACRYGDDLCNTKQEIAEIN--
RMIQRLRSE-I--EHVKK------------------------------------------
-----Q-CT--SLQSAIADAEQ-RGELAL-RDAKNKL----AELENALQKAKQDMAQLLK
DYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLY-G
EA---G-QV-------N-IS----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

-----------------------------------------------------MNGVNWS
------------------------------------QDLQEGISSWFGPPASTPASTMSI
R--VTQKSYK--VST--SGPRAFSSRSYTSGPG-----ARI-SSSSF-------------
-------------------------------------------------------SRVGS
S----------------------------------SFRGG------------LGGGY---
------------------------------------------------------------
-------------------GGPS-------GMGGI------TAVTVNQSLLSPL----NL
EVDPNIQA--VRT QEKEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQQ-QKT-----ARSNM--DNMFE-SYINNLRRQLETLGQ
EKLKLEAELGN-MQGLVEDFKNK-YEDEINKRTE---MENEFVLIK--K---DVDEAYMN
KVELESRLEGLTDEINFLRQLYEE-----EIRELQSQISDT----SVVLSMDNSRSLDMD
SIIA-EVKAQYEEIAN-RSRAEAESMYQIK--YEELQSLAGKHGDDLRRTKTEISEMN--
RNISRLQAE-I--EGLKG------------------------------------------
-----Q-RA--SLEAAIADAEQ-RGELAI-KDANAKL----SELEAALQRAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEES---------------------------RLE-S
---GM---Q--------NMSIHTKTTSG--------------------------------
---------------YAG---------------------GLSS-----------------
---AYG------------------------------GLTSPGLSYGLG------------
--------------------------------SS---------FGSGA---------GSS
SFSRT-------------------SSSRAVVVKKI------ETRDGKLVSESSDVLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MST
R-------------F---SSQVFSSRSATFPGR----GAQV-RLSSA----HTGG-----
----------------------------------------------SR---SSSLYGLG-
------------AP-RPRAAM--HS-----------------------------------
---------------AYG------------------------------------------
----------------G-------P-----VGAGI------HQVTINQSLLAPM----QV
DIDPSIQQ--VRQEEREQIKILNNKFASF------IDK--VR------------------
----FLEQQNK-LLETKWALLQEQKSV-----KSSCV--PGIFE-AYIAGLRKQLEALQM
DGSRLEMELRS-TQDVVEDFKNK-YEEEINRRTA---AENEFVVLK--K---DVDVAYMS
KVELEAKVNALNEDIDFLRTFYET-----ELSELRSQISDT----SVVLSMDNSRSLDLD
SIIA-EVKTQYEEMAN-RSRAEAETAYQTK--LETLQAQAGKHGADLRNTRNEIAEMN--
RAMQRLQAE-I--DNIKN------------------------------------------
-----Q-RA--KLEAAITEAED-RGEMAL-KDARAKQ----EELEAALQRARQDMARQLR
EYQELMNIKLALDIEIATYRKLLEGEE--------------------------G-RLT-G
DGVGA---L--------NISV---------------------------------------
----MNTT-GGGGSGLT--------------------YSGLAFGG-----TMGSNALRFS
SG---------T------------------------------------------------
--------QKAYSMRTTSGTRRSVLN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSR
QFT-----CK----SGAAAKGGFSGCSAVLSGGS------------SS-SFRAG------
------------------------------------------SKGLSGGFGSRSLYSLGG
V-RS--LNVASGSG-KSGGY----------------------------------------
-------------------------------GFGRGRA----------------------
------SGFAGSMFGSVALGPVCPT-VC--PPGGI------HQVTVNESLLAPL----NV
ELDPEIQK--VRA QEREQIKALNNKFASF------IDK--VR------------------
----FLEQQNQ-VLETKWELLQQLDLNN----CKNNL--EPILE-GYISNLRKQLETLSG
DRVRLDSELRN-VRDVVEDYKKR-YEEEINKRTA---AENEFVLLK--K---DVDAAYAN
KVELQAKVESMDQEIKFFRCLFEA-----EITQIQSHISDM----SVILSMDNNRNLDLD
SIID-EVRTQYEEIAL-KSKAEAEALYQTK--FQELQLAAGRHGDDLKNTKNEISELT--
RLIQRIRSE-I--ENVKK------------------------------------------
-----Q-AS--NLETAIADAEQ-RGDNAL-KDARAKL----DELEGALHQAKEELARMLR
EYQELMSLKLALDMEIATYRKLLESEE--------------------------C-RMS-G
EFPS-P--V--------SISIISSTSGGSV------------------------------
------------YGFRPSMVSGG-YV----ANSSNC-----ISGVCSVRGGEGRSRG---
SA--------------------NDYKDTLGKG----------SSLSA-------------
------------------------------------------------------------
----------------------------------P----SKK------------------
------------------------------------------------------------
----------TSR-----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQASKI--S--GGGSQGFSGRSAVVSG------SSR-M-SS---VAWSGGA-G--
-----RG-------------------------ACGFR----SG---AGNFGSRSLYNLGG
N-KSISISVAAGGS-RAGGFGGGRS------SYG--FGGGYGG--------SFGGGFGGG
RG----MGGGFGGAGGFG--------------GA-----GGFGGLGGFGGPGSFGGPGGF
GP------------------------GG--FPGGI------QEVTVNQSLLQPL----NV
EIDPQIGQ--VKA QEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQQQGTSSI--SGTNNL--EPLFE-NHINYLRSYLDNIFG
ERSRLDSELRS-MQELVEDFKKK-YEDEINKRTA---AENEFVTLK--K---DVDTAYMN
KVELQAKVDALLDEIDFLRTLYNA-----ELSQMQSHVSDM----SVVLSMDNNRCLDLD
SIIA-EVRAQYEEIAQ-RSKAEAEALYQTK--LGELQTTAGRHGDDLRNTKSEIIELN--
RMIQRLRAE-I--ENVKK------------------------------------------
-----Q-NA--NLQTAIVEAEQ-RGEMAL-KDANAKL----QELQAALQQAKDDLARLLR
DYQELMNVKLALDVEIATYRKLLEGEE--------------------------Y-RMS-G
ECPSA---V--------SISVVSSSSA---------------------------------
--------TSASAGG---------------------YGGGLGG-----------------
--------------------GF----GAGG---------GAGSGFGRGGG-G-GIGGG--
F--------GFG------------------------------GGSSSSGF--SGGSGF--
GSGSG--AR-YVISGGGFSS----ASNRSGSIKLS----QSS------------------
------------------------------------------------------------
----------Q----RYSR-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTQKSYK--VST--SGPRAFSSRSYTSGPG-----SRI-SSSSF-------------
-------------------------------------------------------SRVGS
S----------------------------------NFRGG------------LGGGY---
------------------------------------------------------------
-------------------GGAS-------GMGGI------TAVTVNQSLLSPL----VL
EVDPNIQA--VRT QEKEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQQ-QKT-----ARSNM--DNMFE-SYINNLRRQLETLGQ
EKLKLEAELGN-MQGLVEDFKNK-YEDEINKRTE---MENEFVLIK--K---DVDEAYMN
KVELESRLEGLTDEINFLRQLYEE-----EIRELQSQISDT----SVVLSMDNSRSLDMD
SIIA-EVKAQYEDIAN-RSRAEAESMYQIK--YEELQSLAGKHGDDLRRTKTEISEMN--
RNISRLQAE-I--EGLKG------------------------------------------
-----Q-RA--SLEAAIADAEQ-RGELAI-KDANAKL----SELEAALQRAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEES---------------------------RLE-S
---GM---Q--------NMSIHTKTTSG--------------------------------
---------------YAG---------------------GLSS-----------------
---AYG------------------------------GLTSPGLSYGLG------------
--------------------------------SS---------FGSGA---------GSS
SFSRT-------------------SSSRAVVVKKI------ETRDGKLVSESSDVLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTQKSYK--VST--SGPRAFSSRSYTSGPG-----SRI-SSSSF-------------
-------------------------------------------------------SRVGS
S----------------------S-----------SFRGG------------VG------
-------------------L----------------------------------------
---------------GGY-GGAG-------GVGGI------TAVQVNQSLLNPL----NL
EVDPNIQA--VRI QEKEQIKNLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQQ-QKT-----SRSNM--DNMFE-SYINNLRRQLDTLGQ
EKLKLEAELGN-MQGM--------YEDEINKRTE---MENEFVLIK--K---DVDEAYMN
KVELESRLEGLTDEINFLRQLYEE-----EIRELQSQISDT----SVVLSMDNSRSLDLD
GIIA-EVKAQYEEIAN-RSRAEAESMYQIK--YEELQTLAGKHGDDLRRTKSEISEMN--
RSISRLQAE-I--EALKG------------------------------------------
-----Q-RA--ALEAAIADAEQ-RGEMAI-KDANAKL----AQLESALQKAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEEN---------------------------RLE-A
---GM---Q--------NLSIHTKTTSG--------------------------------
---------------YAG---------------------MVSS-----------------
---PYG------------------------------GLTSPGFGSLT-------------
---------------------------------------------------------SPG
F---T-------------------RTKSAVVVKKI------ETRDGKLVSETSDVLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MLARNQGNR-----VSSSRGFSGGSAV-VGG----SRRI-AFSSAS---VSGGG----
-----------------------------------------GRGCSGGGFGSKSLYNMGR
T-KS--LSVAGCRQ-GA-GFG---------------FGA---------------------
--------------GGFGA---------------GGFGAGGFG-----------------
--AGGFGG----AFG--GQGGPNFP-VC--PAGGI------QEVTINQSLLTPL----HL
EIDPEIQK--VRTEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQQQTVTT----SGRNL--EPYFE-SYINCLRKQLDGLSN
EKSRLLSELKV-MQDSVEDFKHK-YEEEINKRTT---AENDFVVLK--K---DVDSAYMA
KVLLEAKMDSQNDEINFMKALYEL-----ELSQMQSHVSDT----SVILSMDNNRTLDLN
SIIN-EIQLQYEDIIQ-KSKVEAQNLYQNK--VQQLQNSVDLHGDSLKNTKSEISELN--
RMIQRLRAE-I--ENVKK------------------------------------------
-----Q-CQ--TLQTSVAEAEQ-RGEVAL-KDAITKR----TELEAALRKAKEELTRLLR
EYQDLMNTKVALDLEIATYRKLLEGEE--------------------------C-RMS-G
ECQSA---V--------SISVVSGNISSGA------------------------------
---------------LGGGY---SG-----------------------------------
----LGL------------------------GGGLSSGFGSGSGFAISS-----------
-----GGVSSNKMVSSASLSKRTSR-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTQKSYK--VST--SGPRAFSSRSYTSGPG-----ARI-SSSSF-------------
-------------------------------------------------------SRVGS
G----------------------S-----------SFRGG------------LGTSM---
--------------GL---G----------------------------------------
---------------GFS-GA-G-------VGGGI------TAVTVNQSLLSPL----KL
EVDPNIQA--VRT QEKEQIKSLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQQ-QKT-----SRSNM--DSMFE-SYINNLRRQLEALGQ
EKLKLEAELGN-MQGLVEDFKNK-YEDEINKRTE---MENEFVLIK--K---DVDEAYMN
KVELESRLEGLTDEINFLRQIHEE-----EIRELQSQISDT----SVVLSMDNSRSLDMD
SIIA-EVRAQYEDIAN-RSRAEAESMYQVK--YEELQTLAGKHGDDLRRTKTEISEMN--
RNISRLQAE-I--DGLKG------------------------------------------
-----Q-KA--TLEAAIADAEQ-RGEMAI-KDANAKL----AQLEAALQQAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEES---------------------------RLE-S
---GM---Q--------NLSIHTKTSSG--------------------------------
---------------YAG---------------------GLNS-----------------
---AYG------------------------------GLTSPGFNYGVSSF-------Q--
--------------------------------PG---------FGSVG---------GSS
SYSRT----------------------KAVVVKKI------ETRDGKLVSESSDILPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MNRQASKT--S--GGGSQGFSGRSAMVSG------SSK-M-SC---VARSGGA-S--
-----GG-------------------------ACGLH----SG---AGGFGSRSLYNLGG
N-KSISISVAGGGS-RAGGFGGGRS------SCG--FGGGYGSGFGGGYGG----GLGGS
RG----VGGGFGRAGGFG--------------GA-----GGFGGAGGFGGAGGFGGLGGL
GGPG----------------------GL--FPGGI------QEVTVNQSLLQPL----NV
EIDPQIGQ--VKAQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQQQGTNSI--TGTNNL--EPLFE-NHINYLRSYLDNILG
ERGRLDSELRN-MQDVVEDFKKK-YEDEINKRTA---AENEFVTLK--K---DVDAAYIN
KVELQAKFDALMDEINFLRTLYDA-----ELSQMQSHVSDT----SVVLSMDNNRFLDLD
SIIA-DVRAQYEDIAQ-RSKAEAEALYQTK--LGELQTTAGRHGDDLRSTKSEIMELN--
RMMQRLRTE-I--ENIKK------------------------------------------
-----Q-NA--NLQTAIAEAEQ-HGEMAL-KDANAKL----QELQAALQQAKDDLARLLK
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------S-RMS-G
ECPSA---V--------SISVVSSSSA---------------------------------
--------TTASAGGYGGG-LG--------------VGGGAGG-----------------
--------------------GF----GLGG---------C--SGFGGGGG-GSSIGFG--
G--------GGGF-----------------------------G--GGSGF--SGGSSLGF
GSGSG--GR-CGVSGGGFSS----GSTRVGSAKFS----QSS------------------
------------------------------------------------------------
----------QRC-SR--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQSSVS--FR-SGGSRSFSAASAITPS-----VSRT-SFSSV---SRCGGGG-GG
GGGRVS--------------------------LG-------GA-YGAGGYGSRSLYNLGG
S-KRISFSSS----GG--SFRNR-------------LGAGAG--------GGFGAGA-G-
--------------SGFGFG--GGAG-A------------------------GF----GF
G--GGAGFG-G-GYGGAGFP------VC--PPGGI------QEVTINQNLLTPL----NL
QIDPTIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TIRQNL--DPLFE-QYINNLRRQLDGVLG
ERGRLDSELRN-MQDLVEDFKNK-YEDEINKRTT---AENEFVMLK--K---DVDAAYMN
KVELEAKVDALMDEINFMKMFFDA-----ELSQMQTHVSDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEDIAN-RSRTEAETWYQTK--YEELQQTAGRHGDDLRNTKHEISEMN--
RMIQRLRSE-I--DNVKK------------------------------------------
-----Q-CA--NLQNAIADAEQ-RGELAL-KDARNKL----AELEEALQKAKQDMARLLR
EYQELMNTKLSLDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VG-PV-------N-ISVVTNSV----------------------------------
------------SSGYGGGS--GFGG----G---L----GGGLGGGLGSG----L-----
-----G----------------------------------------GGGG----GSYYS-
-----------------------SSSG-----GIGLG--GGLGVGG-------------S
GFSAS---SGRGMGMGFGS----GGG-SSSSVKFV----STTS-S---------------
------------------------------------------------------------
-------------SRRSFKS----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQACKK--SF-SCGSQGFSGRSAVVSG------SSR-S-SC---VARSGAA-G--
-----GG-------------------------ACGFR----SG---AGSLGSHSLYSLGG
S-KSISISVAAGGS-RAGGFSGGRS------SCGSGFGSSYGGSFGGSRG----------
------MGG-------------------------------------------GFGGASGF
GGAG--------GFGR---PGSFGP-GS--CPGGI------QEVTINQSLLQPL----NV
EIDPQIGQ--VKA QEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWELLQQQTTRSG--SGPQNL--EPFFE-SYISCLRKQLDSLLG
AKGSLEGELKN-MQDLVEDFKKK-YEEEINRRTA---AENEFVGLK--K---DVDGAFMN
KVELQAKVDSLTDEINFLRTLYDM-----ELSQMQSHVSDT----SVVLSMDNNRCLDLD
SIIA-EVKAQYEDIAQ-RSKAEAEALYQTK--LGELQTTAGRHGDDLRSTKSEIMDLN--
RMIQRLRAE-I--ENVKK------------------------------------------
-----Q-NT--NLQTSIAEAEQ-RGERAL-KDADTKL----QDLQVALQKAKEDMARLLR
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EFQNA---V--------SISVVSNVTS---------------------------------
--------TSSN----SGGFRGTGSS----NY--G----GD-------------------
----------------NSGRS---------------------------SS--S-------
-----------S------------SRGSSNRGSS------GSRLGSGGSI--SV-SQQRM
GFNSG--GS-QTSVGSNYTS----GRGGSSSVHFS----QTT------------------
------------------------------------------------------------
----------SSS-QQRSK-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MIARQSSVR-----G-VSRGFSSGSAI-AGG----VKRV-AFSSGS---MSGGA----
-----------------------------------------GRCS-AGGFGSRSLYNLGG
H-KSISMSVAGSCQ-GG-GYGGAGG-----------FGVGG-------------------
----------------YG----------------AGFGAGGFG-----------------
---GGFGG----SFN--GRGGPGFP-VC--PAGGI------QEVTINQSLLTPL----QV
EIDPEIQK--IRTA EREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQQQTTTT----SPRNL--DPFFE-TYINALRKNLDTLSN
DKGRLQSELKM-MQDSVEDFKTK-YEEEINKRTA---AENDFVVLK--K---DVDAAYMI
KVELEAKMESLKDEINFTRVLYEA-----ELAQMQTHVSDT----SVVLSMDNNRNLDLD
GIIA-EVRAQYEEIAR-KSKAEVESWYQIK--VQQLQMSADQHGDSLKTTKNEISELN--
RMIQRLRAE-I--ENIKK------------------------------------------
-----Q-CQ--TLQASVADAEQ-RGELAL-KDAYSKR----TELETALQKAKEDLARLLR
DYQALMNVKLALDVEIATYRKLLEGEE--------------------------C-RMS-G
ECKSA---V--------SISVVGGSASIGG------------------------------
------------------------S------------------------------GL---
---GLGS------------------------GFCSGSG--SGSSFGF--G-GG-------
----IYGGSGSKITSSATIT--KRSPR---------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQASKT--S--GGGSQGFSGGSAVVSS------SSR-M-SC---VTRSGVA-G--
-----GG-------------------------AYGFR----SG---AGGFGSRSLYNLGG
N-KSISISVAAGGP-RAGGFGGGRS------SCG--FAGGYGGGFGGGYGGGFGGGFGGV
RG----MGGGFGGAGGFG--------------GA-----GGFGGASGFGGPGGFGSPGGF
GP------------------------GG--FPGGI------QEVTINQSLLQPL----NV
EIDPQIGQ--VKA QEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQQQSTSSI--SGTNNL--EPLFE-NHINYLRSYLDNILG
ERGRLDSEMRN-MQDLVEDFKKK-YEDEINKRTA---AENEFVTLK--K---DVDGAYMN
KVELQAKVDALIDEINFLRTLYDA-----ELSQMQSHISDT----SVVLSMDNNRSLDLD
SIIA-EVRAQYEDIAQ-RSKAEAEALYQTK--LGELQTTAGRHGDDLRNTKSEIIELN--
RMIQRLRAE-I--ESIKK------------------------------------------
-----Q-NA--NLQTAIVEAEQ-RGEMAL-KDANTKL----QELQAALQQAKDDLARLLR
DYQELMNVKLALDVEIATYRKLLEGEE--------------------------Y-RMS-G
ECPSA---V--------SISVVSSSTT---------------------------------
--------S-ASAGGYAGG-YGGG------------VGGGLGG-----------------
--------------------GL----GAGG---------GSSSGFGRGGG-G-GIGGG--
I--------GGGI-----------------------------GGGIGGG-----------
----------FGVSGGGFSS----ASNRGGSIKFS----QSS------------------
------------------------------------------------------------
----------QSS-QRYSR-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQSSVS--FR-SGGSRSFSAASAITPS-----VSRT-SFSSV---SRSRG----G
GGSRVS--------------------------LG-------GA-YGGGGFGSRSLYNLGG
S-RKISISTS----GG--GFRNQ-------------FGVGAGG----G--YGFGGGA-G-
--------------SGFGFG--AGMG-G------------------------GL----GL
G--GGAGFG-G-GYGGAGFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPTIQR--VRTEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVRQSL--EPLFE-QYINNLRRQLDSILG
ERGRLDSELRN-MQDLVEDFKNK-YEDEINKRTT---AENEFVMLK--K---DVDAAYMS
KVELEAKVDALMDEINFLKMFYDA-----ELSQMQTHVSDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEEIAN-RSRTEAESWYQTK--YEELQQTAGRHGDDLRNTKHEISEMN--
RMIQRLRSE-I--DNVKK------------------------------------------
-----Q-CA--NLQNAIADAEQ-RGELAL-KDARNKL----AELEEALQKAKQDMARLLR
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VG-PV-------N-ISVVTNSI----------------------------------
------------STGYGGGS--SFGG----G---SGFGGG--LGGGLGSG----L-----
-----G----------------------------------------GGGG----GSLYS-
-----------------------SSS------GGGLG--GGLSVGG-------------S
GFSAS---SGRGMGMGFGS----SGG-SSSSVKFV----STTS-S---------------
------------------------------------------------------------
-------------SRRSFKS----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
MA--STSTTIR--SH-SSSRRGFSASSARLPG-----VSRS-GFSSVS-VSHSRGSGGLG
G-------------------------------AC-----------GGAGFGSRSLYGLGG
S-KRISIGGG----SC--AISGG-------------YGS--RA----GGSYGFGG-A-G-
--------------SGFGFG--GG--A------GI-----------------GF----GL
A--GG-AGLAG-GFGGPGFP------VC--PPGGI------QEVTINQSLLTPL----NL
QIDPTIQR--VRA EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWTLLQEQGTK----TVRQNL--EPLFE-QYINNLRRQLDSIVG
ERGRLDSELRG-MQDLVEDFKNK-YEDEINKRTA---AENEFVTLK--K---DVDAAYMN
KVELQAKADTLTDEINFLRALYDA-----ELSQMQTHISDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEEIAQ-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEIAEIN--
RMIQRLRSE-I--DHVKK------------------------------------------
-----Q-CA--NLQAAIADAEQ-RGEMAL-KDAKNKL----EGLEDALQKAKQDLARLLK
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLN-G
EG--VG-QV-------N-ISVVQSTV----------------------------------
------------SSGYGSASG-------------------------I-------------
---------------------------------------GSGLGLGGGSG----YS----
-----------------------YGSG--------------LGVG--------------G
GFSSS---SGRAIG--GGLS--SVGGG-SSTIKYT----TTSS-----------------
------------------------------------------------------------
------------SSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTQKSYK--VST--SGPGAFSSRSFMSGPI-----ACL----SF-------------
-------------------------------------------------------SQVSS
S----------------------------------GFRGG------------LGAGY---
--------------A---------------------------------------------
------------------GASGI-------GLGGI------TAVTISQSLLNPI----KM
DVDPNIQA--VRT QEKEQIKTLDNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQQ-QKT-----ARGNM--DNMFE-SYINNLRQHLETLGQ
EKLKLEAELGN-MQGLVEDFKNK-YEEEINKRTE---MENEFVLIK--K---DVNEAYMN
KVELESRLEGLTDEISFLRQLYEE-----EIRELQSQISDT----SVVLSMDNSRSLDMD
SIIT-EVKAQYEEIAN-RSWAEAESVYQIK--YEELQMLAGKHGDDLRRTKTEISEMN--
RNISRLQAE-I--EGLKG------------------------------------------
-----Q-RA--SLEATIADAEQ-RGDLAL-KDACAKQ----QELETALQRAKQDM-----
---ELMNVKLALDIEIATYRKLLEGKES---------------------------RLE-S
---GM---R--------NMSIHTKTTSG--------------------------------
---------------YAG---------------------GLSS-----------------
---AYG------------------------------GLTSPGLSYGLG------------
---------------------------------S--------SFGSGM---------GFS
SISRT-------------------SSTEAVVVKKI------ETRNGRLVSKSFDILPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSSKTTVR--SQS-TSRRGFSASSARVPG-----LSRS-GFSSVS-VCRSRGSGGTG
A-------------------------------MY-----------GGAGFGSRSLYNLGG
S-KRISIGGG----SC--AIGGG-------------YGS--RV----GGGFGFGGGI-G-
--------------NGFGYG--GG--A---------------------------------
------AGFGG-GYGGAGFP------VC--PPGGI------QEVTINQSLLTPL----NL
EIDPTIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWSLLQEQGTR----TVRHSL--EPLFE-QYINNLRRQLDSIVS
ERGRLDSELRN-MQDAVEDYKNK-YEHEINKRTT---AENEFVTLK--K---DVDAAYMN
KTELQAKADGLVDEINFLRALYEA-----ELSQMQTHVSDT----SVILSMDNNRSLDLD
SIIA-EVRAQYEEIAQ-RSRAEAESWYQSK--YEELQVTAGRHGDDLRNTKQEIAEIN--
RMIQRLRSE-I--DHVKK------------------------------------------
-----Q-CA--NLQAAIADAEQ-RGELAI-KDARSKL----EGLEDALQNAKQDLARMLK
QYQELLNVKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VG-PV-------N-ISVVQSTV----------------------------------
------------SSGYGSS-------------------------SGV-------------
---------------------------------------GSGLGLGGS-S----GYTY--
------------------------SSG--------------HSLG--------------S
GFSSG---SGRGTSIGGGHI--SVGG-GS----YT----SS-S-----------------
------------------------------------------------------------
------------SSRKSYKY----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
-------------------------------------------------------STMSR
QAGYSQQSCRS--S---------SGRSAAVSGQSRVT-SSK-S-SL---ASRSGGG-G--
-----GG-----------------------SAACAMM---------GGGFGSRSLYNLGG
S-KKISISVAGGSI-RAGGFGSTSG------G--------YLGG----------SGF-GG
GGR--GMGGGFG------------------------------------------------
-----------------------GR-GG--FPGGI------QEVTINQSLLQPL----NV
EIDSQIGQ--VKAQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWSLLQEQGSGTN--TNNHNL--EPFFE-NYISSLRAFLDGLHV
EKDKLQEELRS-MEGMVEDFKKR-YEEEISKRTA---AENDFVVLK--K---DIDAAYMT
NAELEAKVHSVTDEVNFLKALYDA-----ELSQMHSDTGNT----SVVLSMDNNRCLDLD
SIIA-EVRAQYEAIAQ-RSKAEAEALYQSK--LGELQTTAGMHGDDLKSIKSEVMELS--
RMIQRLRAE-I--ESLKK------------------------------------------
-----Q-NA--NLQTAIADAEQ-RGEVAL-KDANAKL----QDLKAALQQAKEDLARLLK
EYQELMNVKLALDIEIATYRTLLEGEE--------------------------CRLV--G
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSV
R--VTQKSYK--MST--SGPRAFSSRSFTSGPG-----ARI-SSSSF-------------
-------------------------------------------------------SRVGS
S---------------------SS-----------SFRGS------------L-------
-------------------G----------------------------------------
---------------GF---GGA-------GVGGI------TAVTVNQSLLNPL----KL
EVDPNIQA--VRT QEKEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQQ-QKT-----SRSNM--DNMFE-SYINNLRRQLEALGQ
EKLKLEVELGN-MQGLVEDFKNK-YEDEINKRTE---MENEFVLIK--K---DVDEAYMN
KVELESRLEGLTDEINFLRQIHEE-----EIRELQSQISDT----SVVLSMDNSRSLDMD
SIIA-EVRAQYEEIAN-RSRAEAETMYQIK--YEELQTLAGKHGDDLRRSKTEISEMN--
RNISRLQAE-I--DALKG------------------------------------------
-----Q-RA--TLEAAIADAEQ-RGELAV-KDANAKL----EDLKNALQKAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEES---------------------------RLE-S
---GM---Q--------NMSIHTKTTSG--------------------------------
---------------YAG---------------------GLSS-----------------
---SYG------------------------------GLTSPGFSYGMSSF-------Q--
--------------------------------PG---------FGSVG---------GSS
TYSRT----------------------KAVVVKKI------ETRDGKLVSESSDIMSK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTQKSYK--MST--SGPRAFSSRSFTSGPG-----ARI-SSSSF-------------
-------------------------------------------------------SRVGS
S---------------------SS-----------SFRGS------------LGSSM---
--------------GL---G----------------------------------------
---------------GF---GGA-------GVGGI------TAVTVNQSLLSPL----KL
EVDPNIQA--VRT QEKEQIKSLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQQ-QKT-----SRSNM--DNMFE-SYINNLRRQLEALGQ
EKLKLEAELGN-MQGLVEDFKNK-YEDEINKRTE---MENAFVLIK--K---DVDEAYMN
KVELESRLEGLTDEINFLRQLHEE-----EIRELQSQISDT----SVVLSMDNSRSLDMD
SIIA-EVRAQYEEIAN-RSRAEAEAMYQIK--YEELQILAGKHGDDLRRSKTEISEMN--
RNISRLQAE-I--EALKG------------------------------------------
-----Q-RA--TLDAAIADAEQ-RGEMAI-KDAQTKV----TELEAALTRAKQDMAKQLR
EYQELMNVKLALDIEITTYRKLLEGEES---------------------------RLE-S
---GM---Q--------NMSIHTKTTSG--------------------------------
---------------YSG---------------------GLSS-----------------
---SYG------------------------------GLTSPGYSYGMNSF-------Q--
--------------------------------SG---------FGSVG---------GSS
TYSRS----------------------KAVVVKKI------ETRDGKLVSESSDVVSK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------M--
----NRQVCRT--S--GGGSQGFSGRSAVVSG------STR-M-SC---VARSGGA-S--
-----GG-------------------------ACGFR----SG---AGGFGSRSLYNLGG
N-KSISISVAGGSS-RAGGFGGGRS------S--CGFGSGYGSGFGGGYGG----GFGGG
--R--GMGGGFGGAGGFG--------GAGGFGGA-----GGLGGPGGFGGPGGFGGAGGL
GGPGGFGGPS--GFGG---P------GG--FPGGI------QEVTVNQSLLQPL----NV
EIDPQIGQ--VKA QEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQQQGTHST--TGTNNL--EPLFE-NRINYLRSYLDSILG
ERGRLDSELRN-MQDLVEDFKKK-YEDEINKRTA---AENEFVTLK--K---DVDAAYMN
KVELQAKVDALMDEINFLRTLYDA-----ELSQMQSHVSDT----SVVLSMDNNRCLDLD
SIIA-DVRAQYEDIAQ-RSKAEAEALYQTK--LGELQTTAGRHGDDLRSTKSEIVELN--
RMIQRLRAE-I--ENVKK------------------------------------------
-----Q-NA--NLQTAIAEAEQ-RGEMAL-KDANAKL----QELQAALQQAKDDLARLLR
DYQELMNVKLALDVEIATYRKLLEGEE--------------------------Y-RMS-G
ECPSA---V--------SISVVSNSS----------------------------------
-------TTSASAGGYGGGYGG-------------GLGGGAGSGF---------------
--------------------GR----GG------------SSGGFGTGGS--GGFGG---
---GTSGGF--------------GT----------------------GGG--F-GGGSSF
GSGSG--GR-CGVSGGGFSS----GSNRGGSITFS----QSS------------------
------------------------------------------------------------
----------QRC-SR--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R-V-TQKSYK--VST--SGPRAFSSLSYTSGPA-----SRI-SSSSF-------------
-------------------------------------------------------SRMGS
R----------------------G-----------SFRGG------------MGL-----
------------------------------------------------------------
---------------GGY-GGAG-------GVGSI------TAVQVNQSLLNPL----NL
EVDPNIQA--VRI QEKEQIKNLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQQ--KT-----SWSNM--DNMFE-SYINNLRRQLDSLGQ
EKMKLEAELGN-MQGLVEDFKNK-YEDEINKRTE---MENEFVLIK--K---DVDEAYMN
KVELESRLEGLTDEINFLRQLYEE-----EIRELQSQISDT----SVVLSMDNSRSLDLD
GIIA-EVKAQYEEIAN-RSRAEAESMYQIK--YEELQTLAGKHGDDLRRTKTEISEIT--
RSISRLQAE-I--EALKG------------------------------------------
-----Q------------------GEMAI-KDANAKL----AQLEAALQKAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEEH---------------------------RLE-A
---GM---Q--------NLSIHTKTTSG--------------------------------
---------------YSG---------------------MVSS-----------------
---PYG------------------------------GLTSPGFASIQS------------
---------------------------------P--------------------------
GF--T-------------------RTKSAVVVKKI------ETRDGKLVSETSDVLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R-V-TQKSYK--VST--SGPRAFSSLSYTSGPA-----SRI-SSSSF-------------
-------------------------------------------------------SRMGS
S----------------------G-----------SFRGS------------MGL-----
------------------------------------------------------------
---------------GGY-GGAG-------GVGSI------TAVQVNQSLLNPL----NL
EMV P---------------KNLNNKFTSF------IHK--VR------------------
----FLEQQNK-MLETKWSLLQQ-QKT-----SRSNM--D-MFE-SYINNLRWQLDSLGQ
EKMKLEAELGN-MQGLVEDFKNK-YEDEINKRTE---MENEFVLIK--K---DVDEAYVN
KVELKSRLEGLTDEINFLRQLYEE-----EIRELQSQISDT----SVVLPMDNNRSLDLD
GIIA-EVKAQYEEIAN-RSCAEAESMYQIK--YEELQTLAGKHEDDLRCTKTEISEIT--
RSISRLQAE-I--EALKG------------------------------------------
-----Q-RA--SLEAAIADAEQ-RGEMDI-KDANAKL----AQLEAALQKAKQDMARQLR
EYQELMNVKLALDIEIATYCKLLEGEEN---------------------------RLE-A
---GI-------------------------------------------------------
------------------------------------------S-----------------
---PYG------------------------------GLTNPGFASLQS------------
---------------------------------P--------------------------
GF--T-------------------RTKSAVVVKKI------ETRDGKLVSETSDVLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQST----VRIQRGRSGFSAASAVVPN-----TCRT-SFSSCS-VTRLGSCNA--
-------------------------------------GSGFARVGG--GFGSKSLYNVGG
C-KKISVAGRGGS----F-Y--GS------------------------------------
--------------AGFGGF-------G--VPANLG------------------------
---------Y--GYGA-FGGGPGF------PAGGI------HEVSINQSLLKPL----NL
EIDPNIQR--IRKEEKEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWSLLQEQGMKT----VKNNL--EPLFE-TYINNLRVQLNSLLS
DKGRLEGELVN-TQYLVEDFKKK-YEDEINRRTI---AENEFVTLK--K---DVDASYMN
KVELQARADALSEEINFLRALYEA-----ELSQMQTQISDT----SVVLTMDNNRNLDLD
SIIS-EVKAQYEEIAN-RSRAEAESWYQTK--YEELQATAGRHGDDLRSTKQEISELN--
RHVQRLRSE-I--DSVKK------------------------------------------
-----Q-CA--NLKAAIADAEE-RGELTL-KDARAKL----AELEDALQQAKADLARQLR
EYQELMNVKLALDIEIATYRKLLEGEE--------------------------C-RLA-G
DGV--P--V--------NISVTRTTV----------------------------------
----------------GTGYGGGSNL----SMGG-----------------GICNLGNSF
NCGSV-------------------------------------------------------
------------------------------------------------------------
----------P-GVNSSTF-GA----GSSSSMKFV----SSS------------------
------------------------------------------------------------
-----------ST-RRSYRS----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
----------------------------------------------------------MS
SKTIR---------SQSSSHGGFCASLARVSG-----LSHS-GFRGGS-TCHIRGNG---
-----S-----------------------------M----QTACG-GAGFGSSTLYDLGD
S-NRISTEGSSCAT-G-DRHGRRVG-----------------------------------
--------------GNF--R----GGISSGLGFGA---------------------G---
-----------ARFNG-GYEGVGFP-MF--SPAGI------QEVTINQSLLTPL----NL
QIDPTIQR--VMT EEREQIKTLNNKFASF------VDK--VR------------------
----FLEQQNR-VLDTKWTLLQEQDTRP----VRPDL--DVLFN-KYISNLRRQLDYIIS
QKSHLDSELSR-TQDTANNLKNK-YEDEVNKHTA---TENEFVTMK--K---NVDAAYMN
DIKLKDMADGLKDEVGFLTTAFEV-----ELSQMQTHISDT----TVVLSMDNNRSLDLD
SIIA-EVKAQYEEITQ-RSRAEAESWYQTK--YEELRLLAGSHGETLHNTKQEIAGIN--
RMIQRLKSE-I--DQVKK------------------------------------------
-----Q-CC--NIQSDVTDAEQ-RGELTL-KDARSKL----EGLEKVLQKGKQHRLMLLK
EYQDLLNVKIILDVEITAYKKLLEAEE--------------------------C------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------M--
----SRQASKT--S--GGGSQGFSGRSAVVSG------SSR-M-SC---VAHSGGA-G--
-----GG-------------------------AYGFR----SG---AGGFGSRSLYNLGG
N-KSISISVAAGGS-RAGGFGGGRS------S--CAFAGGYGGGFGSGYGGGFGGGFGGG
--R--GMGGGFGGAGGFG--------GAGGFGGA-----GGFGGPGGFGGSGGFGGPGSL
GSPGGF---------G---P------GG--FPGGI------QEVTINQSLLQPL----NV
EIDPQIGQ--VKAQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQQQGTSSI--SGTNNL--EPLFE-NHINYLRSYLDNILG
ERGRLDSELKN-MEDLVEDFKKK-YEDEINKRTA---AENEFVTLK--K---DVDSAYMN
KVELQAKVDALIDEIDFLRTLYDA-----ELSQMQSHISDT----SVVLSMDNNRSLDLD
SIIA-EVRAQYEDIAQ-RSKAEAEALYQTK--LGELQTTAGRHGDDLRNTKSEIIELN--
RMIQRLRAE-I--EGVKK------------------------------------------
-----Q-NA--NLQTAIAEAEQ-HGEMAL-KDANAKL----QELQAALQQAKDDLARLLR
DYQELMNVKLALDVEIATYRKLLEGEE--------------------------Y-RMS-G
ECPSA---V--------SISVVSSST----------------------------------
--------TSASAGGYGGGYGG-------------GMGGGLGGGF---------------
--------------------SA----GGG-----------SGSGFGRGGG--GGIGG---
---GFGG------------------GS---------------------SG--F-SGGSGF
GSISG--AR-YGVSGGGFSS----ASNRGGSIKFS----QSS------------------
------------------------------------------------------------
----------QSS-QRYSR-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
-----------------------------------------------------------M
RASMSRQTYNT--------KGGFSSSSASGSRGVGGTHTHT-SFSSTI-VSRGGSRVGG-
--------------------------A--------------SCGSPKTNFGSHSLYNLGA
N-RSVSGNMVQRASQG-KSF----------------------------------------
-----------------GIG------------------AGSFL-----------------
-------GLG-------AGQ--TLG-PC--PLGGI------QEVTVNQSLLTPL----NV
EIDPEIQR--VRIQEKEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQGQSPS---V-LRL--ESLFE-SQINKLGRHLDTLKN
EKEKLDTELCN-VQQQMDNFKDK-YEEEIHKRTE---AENEXXXXX--X---XXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXX-----EREGTHTHSSNT----NVVLSMDNNRSLDLD
SIIA-EVKNQYEEIAK-RSRAEAESWYQTK--YEELQVTAGKHGDCLRDTKNEIAELT--
RVMQRLQGE-I--DSVKK------------------------------------------
-----Q-CQ--QLQTAIADSEQ-RGELAI-KDAQKKL----GDLEKALHHSKEEMTKLLR
DYQELMSIKLALDMEIATYRKLLESEE--------------------------G-RMS-G
ECPNA---I--------SISMTGSSTTVCG------------------------------
-----------------GGA--------------ASFGGGLSLGSS---DG--GVKG---
MD----------------------------------------CGY------------A--
KGGPSTG--GTSIFKTSTSTTVKSSSRRY-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTQKSYK--VST--SAPRSFSSRSYTSGPG-----SRI-SSSAF-------------
-------------------------------------------------------SRVGS
G----------------------S-----------SFRGG------------LGTSM---
--------------SM---A----------------------------------------
---------------GSY-GGN-------------------------QSLLSPL----KL
EVDPNIQA--VRTQEKEQIKTLNNKFASF------IDK--VR------------------
----HLEQQNK-VLETKWNLLQQ-QKT-----ARSNI--DNMFE-SYINSLRRQLETLAQ
DKLKLEVELGN-MQGLVEDFKTK-YEDEIQKRTD---MENEFVIIK--K---DVDEAYMN
KVELESRLEGLTDEINFYRQLYEE-----EIREMQSQISDT----SVVLSMDNNRNLDLD
GIIA-EVKAQYEEIAN-RSRAEAETMYQIK--YEELQTLAGKHGDDLRRTKTEISEMN--
RNISRLQAE-I--EGLKG------------------------------------------
-----Q-RA--SLEAAIADAEQ-RGEMAV-KDAQAKL----AELEAALRNAKQDMARQLR
EYQELMNVKLALDVEIATYRKLLEGEES---------------------------RLE-S
---GM---Q--------NMSIHTKTTSG--------------------------------
---------------YAG---------------------GLTS-----------------
---AYG---------------------------------TPGFNYSLSLA----------
---------------------------------------------SGG---------GPG
SFSRT--------------------SSKAVVVKKI------ETRDGKLVSESSDVLSK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQSSVS--FR-SGGSRSFSTASAITPS-----VSRT-SFTSV---SRSGGG-GGG
GFGRVS--------------------------LG-------GACGV-GGYGSRSLYNLGG
S-KRISISTS----GG--SFRNR-------------FGAG--A----GGSYGFGGGA-G-
--------------SGFGFG--GGAG--------G-----------------GF----GL
G--GGA-GFGG-GFGGPGFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPSIQR--VRTEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVRQNL--EPLFE-QYINNLRRQLDSIVG
ERGRLDSELRN-MQDLVEDFKNK-YEDEINKRTT---AENEFVMLK--K---DVDAAYMN
KVELEAKVDALMDEINFMKMFFDA-----ELSQMQTHVSDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEEIAN-RSRTEAESWYQTK--YEELQQTAGRHGDDLRNTKHEISEMN--
RMIQRLRAE-I--DNVKK------------------------------------------
-----Q-CA--NLQNAIADAEQ-RGELAL-KDARNKL----AELEEALQKAKQDMARLLR
EYQELMNTKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VG-PV-------N-ISVVTSSV----------------------------------
------------SSGYGGGS-G--------------YGG--GL----GGG----L-----
---------GGGL--------------------------GGGLG-GGGSG----SYYSS-
------------------------SSG-----GVGLG--GGLSAGG-------------S
GFSAS---SGRGLGVGFGS---GG-G-SSSSVKFV----STTS-S---------------
------------------------------------------------------------
-------------SRKSFKS----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSVRSTMR--TQ-SSSQRGFSAGSARVPG-----GSRS-GFSSVS-VSRSRS----G
G-------------------------------AC-----------AGAGFGSRSLYGLGG
S-KRISIGGG----SC--AIGGG-------------YGS--RA----GGSFGFGGGM-G-
--------------SGFGFG--GG--A------GS-----------------GF----GL
G---------G-GYGGAGFP------VC--PPGGI------QEVTVNQNLLTPL----NL
QIDPTIQR--VRTEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNR-VLDTKWALLQEQGTK----TVRQNL--EPMFE-QYINNLRRQLDSILG
ERGRLDSELRG-MQDMVEDFKNK-YEEEINKRTT---AENEFVTLK--K---DVDAAYMN
KVELQAKVDTLMDEINFLRALYEA-----ELSQMQTHVSDT----SVVLSMDNNRFLDLD
SIIA-EVKAQYEEIAQ-RSRAEAESWYQTK--YEELQMSAGRHGDDLRNTKQEIAEIN--
RMIQRLRSE-I--DHVKK------------------------------------------
-----Q-NA--NLQSSIADAEQ-RGEMAI-KDAKNKL----MDLEDALQKAKQDMARLLK
EYQELMNTKLALDVEIATYRKLLEGEE--------------------------C-RLN-G
EG--VG-QV-------N-ISVVQSTV----------------------------------
------------SSGYGSG-------------------------SGG-------------
---------------------------------------SSGLSMGGGSG----YS----
-----------------------YGSG-----H-SLG--G--------------------
SFSSG---SGRGLG--GGFS--SSGGS-SSTIKYT----TTS--S---------------
------------------------------------------------------------
------------SSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSCRSTVR--SQ-STSRRGFSAGSARVPG-----VCRS-GFSSVS-VS-SRGGGGLA
G-------------------------------VC-----------GGAGFGSRSLYNLGG
T-KRISI-------------SGG-------------YGS--RY----GGGFGFGGGI-G-
--------------SGYGFG--GA--A-------------------------------GL
G--GG-AGFAG-GYGGAGFP------VC--PPGGI------QEVTVNQSLLTPL----NL
EIDPTIQR--VRTEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVRQNL--EPLFE-QYINNLRRQLDSILG
ERSRLDSELRS-MQDQVEDFKNK-YEDEINKRTA---AENEFVKLK--K---DVDAAYMN
KVELQAKADNLTDEINFLRAFYEA-----ELAQMQTHISDT----SVVLSMDNNRSLDLD
SIIS-EVKAQYEEIAQ-RSRAEAESWYQSK--YEELQVTAGRHGDDMRNTRQEISEIN--
RMVQRLRSE-I--DHVKK------------------------------------------
-----Q-CA--NLQSAIADAEQ-RGELAL-KDAKNKL----ADLEDALHKAKQDMARLLK
EYQELMNVKLALDVEIATYRKLLEGKE--------------------------C-RLS-G
RV--V-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTQKSYK--VST--SGPRAFSSRSYTSGPG-----ARI-SNSSF-------------
-------------------------------------------------------SRTGS
G----------------------------------IFRGS------------LGTGM---
--------------GL---G----------------------------------------
---------------GGF-SGA--------GVGGI------TAVTVNQSLLSPL----KL
EVDPNIQA--VRT QEKEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQQ-QKT-----ARSNM--DNMFE-TYINNLRRQLESLGQ
DKLKLEAELGN-MQGLVEDFKNK-YEDEINKRTE---MENEFVLIK--K---DVDEAYMN
KVELESRLEVLTDEINFLRQLHEE-----EIRELQSQISDT----SVVLSMDNSRSLDMD
GIIA-EVRAQYEDIAN-RSRAEAESMYQIK--YEELQTLAGKHEDDLRSTKKEISDMN--
RSISRLQAE-I--EALKG------------------------------------------
-----Q-RA--TLEAAIADAEH-RGEMAI-KDANAKL----AELEAALQRAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEES---------------------------RLE-S
---GM---Q--------NMSIHTKTTSG--------------------------------
---------------YAG---------------------GLSS-----------------
---SYG------------------------------GLTSPGFSYGVSSF-------P--
--------------------------------PS---------FSPAG---------SSS
TFSRT----------------------KAVVVKKI------ETRDGKLVSESSDILPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
H-------------F---SSPVFTSRSAAFSDR----GAQV-RLSSA----RPGG-----
----------------------------------------------LG-S--SSLYGLG-
------------AS-RPRVAV--RS-----------------------------------
---------------AYG------------------------------------------
----------------G-------P-----VGAGI------REVTINQSLLAPL----RL
DADPSLQR--VRQ EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-LLETKWTLLQEQKSA-----KSSRL--PDVFE-AQIAGLRGQLEALQV
DGGRLEAELRS-MQDVVEDFKNK-YEDEINRRAA---AENEFVVLK--K---DVDAAYMS
KVELEAKVDALNDEINFLRTLNEM-----ELTELQSQISDT----SVVLSMDNSRSLDLD
SIIA-EVKAQYEEMAK-CSRAEAEAWYQTK--FETLQAQAGKHGDDLRNTRNEISEMN--
RAIQRLQAE-I--DNIKN------------------------------------------
-----Q-RA--KLEAAIAEAEE-RGELAL-KDARAKQ----EELEAALQRTKQDMVRQLR
EYQELMSVKLALDIEIATYRKLLEGEE--------------------------S-RLA-G
D-------G--------VGA-----VN---------------------------------
-ISVVNST-GG-----SGNG----------------GGIGLTLGG-----TMGSNALSFS
SS-----AGPGP------------------------------------------------
--------LKAYSIRTTSTSRRSARN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSV
H-------------F---SSPVFTSRSAAFSGR----GAQV-RLSSA----RPGG-----
----------------------------------------------LG-S--SSLYGLG-
------------AS-RPRVAV--RS-----------------------------------
---------------AYG------------------------------------------
----------------G-------P-----VSAGI------REVTINQSLLAPL----RL
DADPSLQR--VRQEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-LLETKWTLLQEQKSA-----KSSRL--PDVFE-AQIAGLRGQLEALQV
DGGRLEVELRS-MQDVVEDFKNK-YEDEINRRAA---AENEFVVLK--K---DVDAAYMS
KVELEAKVDALNDEINFLRTLNET-----ELTELQSQISDT----SVVLSMDNSRSLDLD
GIIA-EVKAQYEEMAK-CSRAEAEAWYQTK--FETLQAQAGKHGEDLRNTRNEISEMN--
RAIQRLQAE-I--DNIKN------------------------------------------
-----Q-RA--KLEAAIAEAEE-RGELAL-KDARAKQ----EELEAALQRAKQDMARQLR
EYQELMSVKLALDIEIATYRKLLEGEE--------------------------S-RLA-G
D-------G--------VGA-----VN---------------------------------
-ISVVNST-GG-----SNSG----------------GGIGLTLGG-----TMGSNALSFS
SS-----AGPGS------------------------------------------------
--------LKAYSIWTASASRRSARN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------M--
----SRQVSKT--S--GGGSQGFSGRSAVVSG------SSR-M-SH---VARTGGV-G--
-----GG-------------------------ACGFR----SG---AGGFGSRSLYNLGG
N-KSISISVAG-GS-WAGGFGGGRG------S--CG------SGFGGGYGGGFGGGFGGG
--R--GMGGGFGGAGGFG--------GAGGFGGA-----GGFGG------------AGGF
GGAGGFGGPG--GFGG---PGGFGP-GG--FPGGI------QEVTVNQSLLQPL----NV
EIDPQIGQ--VKAQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWHLLQQQGTNST--TGTNNL--EPLFE-AYINSQRSYLDGILG
ERGRLDSELRN-MQDLVEDFKKK-YEDEINKRTA---AENEFVTLK--K---DVDAAYMN
KVELQAKADALNDEINFLRTLFDM-----ELSQMQSHVSDT----SVVLSMDNNRFLDLD
SIIA-EVKAQYEEIAQ-KSKAEAEALYQTK--LGELQTTAGRHGDDLKSTKSEISELN--
RMIQRLRAE-I--ENVKK------------------------------------------
-----Q-NA--NLQTAIAEAEQ-RGEMAL-KDANDKL----QELQVALQQAKDDLARLLR
DYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RMS-G
ECQSA---V--------SISVVSGSS----------------------------------
-------TTAASAGGYGGGYGG-------------GFGVGG-------------------
----------------------------G-----------AGSGFGRAGG--SGLGGG--
SGLGSGSGFAGGS----------GLGG--------------------GSG--F-SGGSGF
GSVSG--GR-SGVSGGGFSS----GSTRGGSVRFS----QSS------------------
------------------------------------------------------------
----------QRY-SR--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQACKQ--SF-SRGSQGFSGHSAVVSG------SSR-R-SC---VARTRAA-G--
-----GG-------------------------ACGFR----SG---AGGFGSQSLYNLGG
S-RSISISVAAGGS-QTGGFGRGHG------SCGSGFGGGYGGGFGGSRG----------
------I-----------------------------------------------GGASGF
GGAS--------GFGR---PGGFGP-GS--CPGGI------QEVTINQSLLQPL----NV
EIDPQIGE--VKA QEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQQQTTGSG--SGPQSL--EPFFE-SYISCLRKQLDSLLG
EKGSLEGELKN-MQDLVEDFKKK-YEEEINRRTA---AENEFVEVK--K---DVDVAYMN
KVELQAKVDSLTDEINFLRTLYDM-----ELSQMQSHVSDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEEIAQ-RSKAEAEALYQTK--LGELQTTAGRHGDDLKSTKSEIMDLN--
RMIQRLRAE-I--ENVKK------------------------------------------
-----Q-TA--NLQTSIAEAEQ-RGEGAL-KDADAKL----QDLQAALQKAKDDLARLLR
DYQELMNVKLALDVEIATYCKLLEGEE--------------------------C-RMS-G
ECQSA---V--------SISVVSNVTS---------------------------------
--------TSSS----SGGFRGAGGS----GG--S----SI-------------------
----------------R--------------------------------D--S-------
-----------S------------VSNSCSRDST------GSRLGREDSS--SV-GQRGM
G-------T-QASTGGSYKS----GRGGSGSVHFF----QTT------------------
------------------------------------------------------------
----------SSS-QQRSK-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSL
H-------------F---SSRAFSSRSAAVPGR----GAQV-RLTSG----RRGG-----
----------------------------------------------FG-GS-SSLYGLG-
------------AS-RPRVAV--HS-----------------------------------
---------------AYA------------------------------------------
----------------G-------P-----LGASI------REVTINQSLLAPL----QV
DIDPSIQQ--VRQ EEREQIKTLNDKFASF------IDK--VR------------------
----FLEQQNK-LLETKWALLQEQKSA-----KSSRL--PRIFE-AQIAGLRGQLEALQV
DGSRLEVELRS-MQDVVEDFKNK-YEDEINHRTA---AENEFVVLK--K---DVDAAYMN
KVELEAKVDGLNDEINFLKTLHET-----ELTELQSQNLDT----SVVLSMDNSRSLDLD
GIIA-EVKAQYEEMAH-RSRAEAEAWYQTK--FETLQAQAGKHGDDLRNTQKEIAEMN--
RAIQRLQAE-I--DNIKN------------------------------------------
-----Q-CA--RLEAAIAEAED-HGELAL-KDARAKQ----EELEAALQRAKQDMARQLR
EYQELMSVKLALDVEIATYRKLLEGEE--------------------------S-RLA-G
DGVGA---V--------NISI---------------------------------------
----VNS---------TGGG----------------GGGGLAFGG-----TMGSNALRFS
SS-----AGPGG------------------------------------------------
--------LQAYSIRTASTSRRSARN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--M-SRQSSIT--FQSG-SRRGFSTTSATTPA-----TGRS-RFRSVS-VAHSAA--GNG
GLGRIS--------------------------SA------------GASFGSRSLYNLGG
A-KRVSISGC-GSS-----FRSG-------------FGG--RA----SSGFGV-----N-
--------------SGFGYG--GGVGGGF-------------------------------
--------------SGPSFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPTIQR--VRA EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQGSR----TVRQNL--EPLFD-SYISELRRQLESITT
ERGRLEAELRN-MQDVVEDFKVR-YEDEINKRTA---AENEFVALK--K---DVDAAYMN
KVELEAKVKSLPEEINFLHSVFDA-----ELSQLQTQVSDT----SVVLSMDNSRNLDLD
SIIA-EVKAQYEDIAN-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEISEMN--
RMIQRLRAE-I--DSVKK------------------------------------------
-----Q-CS--SLQTAIADAEQ-RGELAL-KDARAKL----VDLEEALQKAKQDMARLLR
EYQELMNIKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VS-PVNIS--------VVTSTL----------------------------------
------------SSGYGSGS--GIG-----------------------------------
---------------------------------------GGSLGLGGGSG----YSFTT-
-----------------------SG-------GHSLG--A--GLGG-------------S
GFSAT---SNRGLGG------------SGSSVKFV----STTS-----------------
------------------------------------------------------------
------------SSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--M-SRQSTIT--FQTS-GRRGFSTASATTLA-----TGRS-RFSSVS-TTRSTG--GSG
GLGRIS--------------------------GA------------GTGFGSRSLYNLGG
T-KRVSMSGC-GSN-----FRSG-------------FGG--RA----SGGFGV-----S-
--------------GGFGYG--GGVGGGY-------------------------------
--------------GGSSFP------S----SGGI------QEVTVNQSLLTPL----NL
QIDPTIQR--VRKEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWSLLQEQGSK----TVRQNL--EPLFD-TYINDLRRQLDSITS
ERGRLDAELRN-MQDVVEDFKVR-YEDEINKRTA---AENEFVALK--K---DVDAAYMN
KVELEAKVNCLTDEINCFQTLFET-----ELSQMQTRISDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEDIAN-RSRAEAESWYQTK--YDELQVTAGRHGDDLRNTKQEISEMN--
RMIQRLRAE-V--DSVKK------------------------------------------
-----Q-CS--SLQTAIADGEQ-RGELAL-KDARAKL----VELEEALQKAKQDMARLLR
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VS-PVNIS--------VVTSTV----------------------------------
------------SSGYGGSS--GIG-----------------------------------
---------------------------------------GGSLGLSGGSG----YSFTT-
-----------------------SG-------GHGLG--A--GLGG-------------S
GFSAS---SSRGPGG------------SGSSVKFV----STTS-----------------
------------------------------------------------------------
------------SSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQASKT--S--GGGSQGFSGHSAVVSG------SSR-M-SC---VTRSGVA-G--
-----GG-------------------------AYGFR----SR---AGGFGSRSLYNLGG
N-KSISISVAAGGS-RAGGFGGGRS------NCG--FAGGYGGGFGGGHGGGFGGGFGGV
RG----MGGGFGGAGGFG--------------GA-----GGFGGA------GGFGGPGGF
GP------------------------GG--FPGGI------QEVIINQSLLQPL----NV
EIDPQIGQ--VKA QEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQQQSTSSI--SDTNNL--EPLFE-NHINYLRSYLDNILG
ERGRLDSEMRN-MQDLVEDFKKK-YEDEINKRTA---AENEFVTLK--K---DVDSAYMN
KVELQAKVDALIDEINFLRTLYDA-----ELSQMQSHISDT----SVVLSMDNNRSLDLD
SIIA-EVRAQYEDIAQ-RSKAEAEALYQTK--LGELQTTAGRHGDDLRNTKSEIIELN--
RMIQRLRAE-I--ESIKK------------------------------------------
-----Q-NA--NLQTAIVEAEQ-RGEMAL-KDANAKL----QELQAALQQAKDDLARLLR
DYQELMNVKLALDVEIATYHKLLEGEE--------------------------Y-RMS-G
ECPSA---V--------SISVVSSSTT---------------------------------
--------S-ASAGGYAGG-YGGG------------VGGGLGG-----------------
--------------------GL----GAGG---------GSSSGFGRGGG-G-GLGGG--
I--------GGGF-----------------------------GGGSSGGF--SGGSGF--
GSSSG--AR-YGVSGRGFSS----ASNRGGSIKFS----QSS------------------
------------------------------------------------------------
----------QSS-QRYSR-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQSSVS--FR-SGGSRSFSTASAITPS-----VSRT-SFTSV---SRSGGG-GGG
GFGRVS--------------------------LG-------GACGV-GGYGSRSLYNLGG
S-KRISISTS----GG--SFRNR-------------FGAGAGA----GGGYGFGGGA-G-
--------------SGFGFG--GGAG--------G-----------------GF----GL
G--GGA-GFGG-GFGGPGFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPSIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVRQNL--EPLFE-QYINNLRRQLDSIVG
ERGRLDSELRN-MQDLVEDFKNK-YEDEINKRTT---AENEFVMLK--K---DVDAAYMN
KVELEAKVDALMDEINFMKMFFDA-----ELSQMQTHVSDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEEIAN-RSRTEAESWYQTK--YEELQQTAGRHGDDLRNTKHEISEMN--
RMIQRLRAE-I--DNVKK------------------------------------------
-----Q-CV--NLQNAIADAEQ-RGELAL-KDARNKL----AELEEALQKAKQDMARLLR
EYQELMNTKLALDVEIATYRKLLEGEE--------------------------C-R----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRISFRS--ST-GGGMRGFSSGSAIVGGG--GGGTRS-SFSSVS-VSRVGGG-RAG
G-------------------------------GG-------GFG-AGGGFGSRSLYNLGG
S-KRISYSSV----SG--GLRSG-------------AGG--GY----SFGLGYGGGA-G-
--------------AGFGLG--GA--G------GG-----------------GY----GV
G--RG-PGFGG--RGGPGFP------VC--PPGGI------HEVTVNQSLLAPL----KL
DIDPEIQK--VRTQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWTLLQEQGHT----VTRKSL--EPIFE-AYINNLRRQLDSLMG
ERGRLDSELRS-MQDMVEDFKNK-YEDEINRRTG---AENEFVVLK--K---DVDGAYMN
KVELQGKADALADEINFLRALYEA-----ELSQMQQQVSDT----SVVLSMDNNRNLDLN
SIIA-EVKAQYEDIAN-RSRAEAEAWYQNK--YEELQVSAGRHGDDLRNTKIEISEIN--
RMVQRLRNE-I--DSVKK------------------------------------------
-----Q-CA--NLQAAIAEAEE-RGEMAL-KDAKAKL----TELEDALQKAKADLARQLR
EYQELMNVKLALDIEIATYRKLLEGEE--------------------------S-RLA-G
EG--VG-AV-------S-VSVVSSSS----------------------------------
------------GMGYGGGSCL-----------------G------L-------------
---------------------------------------GGGLGMGGGGG----SSSYT-
-----------------------MSSSGFGGGSGGFS--GGLNYGG------------GS
SFSSG---SSRGIS--SSTG--GT-GS-SSSMKFV----SSS------------------
------------------------------------------------------------
------------STRRSYRS----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--M-SRQSTIT--FQTG-SRRGFSTASATTPA-----LGRS-RFSSVS-VARSTG--GNG
GLGRIS--------------------------GA------------GAGFGSRSLYNLGG
S-KRVSIGGC-GGN-----FRSG-------------FGN--RA----SGGFGV-----S-
--------------SGFGYG--GSIGGGF-------------------------------
--------------GGPGFP------AC--PSGGI------QEVTVNQSLLTPL----NL
QIDPTIQR--VRK EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWTLLQEQSTK----TVRQSL--EPLFD-TYINDLRRQLEGITT
ERGRLDAELRN-MQEVVEDFKVR-YEDEINKRTA---AENEFVALK--K---DVDGAYMN
KVELEAKVDSLTDQINFLRMIFEA-----ELSQMQTQVSDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEDIAN-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEISEMN--
RMIQRLRAE-I--DSVKK------------------------------------------
-----Q-CA--SLQTAIADAEQ-RGELAL-KDARAKL----VDLEEALQKAKQDMARLLR
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VS-PVNIS--------VVTSTV----------------------------------
------------SSGHGGGS--SLG-----------------------------------
---------------------------------------GGSLGLGAGSS----YSFTT-
-----------------------SG-------GH--------GLGG-------------S
GFTAS---SNRGLGG------------SGSSVKFV----STTS-----------------
------------------------------------------------------------
------------SSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSM
R--VTQKTYK--VST--SGPRGFSSLSYSSGPS-----SRI-SSSSF-------------
-------------------------------------------------------SRMGS
S----------------------S-----------SFRGG------------LG------
-------------------L----------------------------------------
---------------GGY-GGAA-------GVGGI------TAVQVNQSLLNPL----NL
EVDPNIQA--VRI QEKEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQQ-QKT-----SRSNM--DNMFE-SYINNLRRQLDTLGQ
EKLKLEAELGN-MQGLVEDFKNK-YEDEINKRTE---MENEFVLIK--K---DVDEAYMN
KVELESRLEGLTDEINFLRQLYEE-----EIRELQSQISDT----SVVLSMDNSRSLDLD
GIIA-EVKAQYEEIAN-RSRAEAESMYQIK--YEELQTLAGKHGDDLRRTKSEISEMN--
RSISRLQAE-I--EALKG------------------------------------------
-----Q-RA--SLEAAIADAEQ-RGELAI-KDANAKL----AQLESALQKAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEEN---------------------------RLE-A
---GM---Q--------NMSIHTKTTSG--------------------------------
---------------YSG---------------------MVSS-----------------
---PYG------------------------------GLPSPGFGSLQ-------------
---------------------------------------------------------SPG
F---T-------------------RTKSAVVVKKI------ETRDGKLVSETSDVLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--------MSS--KS-TIIRRGFSTSSARVPA-----GSRS-GFSSVS-VSRSRGGAGLG
G-------------------------------AC-----------GGAGFGSRSLYGLGS
S-KRISIGGG----NY--VMGSG-------------YSS--RV----GGGFGFGGGA-G-
--------------SGFGFG--GG--A------GS-----------------GF----GL
G--GG-AGFGG-GYGGSGFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPTIQR--VRTEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNR-VLDTKWTLLQEQGTK----TVRHSL--EPLFE-QYINSLRRQLDNIQG
EKGRLDSELRG-MHDLVEDYKKK-YEDEVNRRTA---AENEFVTLK--K---DVDAAYMN
KVELQAKADTLRDEIDFLKVLYDA-----ELSQMQTHISDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEEIAQ-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEISEIN--
RMIQRLRSE-I--DHVKK------------------------------------------
-----Q-CA--NLQAAIADAEQ-RGELAL-KDAKNKL----ADLEDALQKAKQDMARLLK
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLN-G
EG--VG-PV-------N-ISVTQSTV----------------------------------
------------SSGYGSAGG-------------------------V-------------
---------------------------------------GGGLGLGAGSG----YS----
-----------------------YGGG--------------LSLG--------------G
GFSSG---SGRGIA--AGLS--STGGS-SSTIKYT----TTSS-----------------
------------------------------------------------------------
------------TSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSV
K--VTQKTTV--QRT-SSGPLNFSSRSYGGGAV-----YGG-GQ----------------
------------------------------------------------------------
--------------------------------------RY------------LGR-P---
--------------AGLG------------------------------------------
---------------------GY-------GAVGF------EAVSINQSLLAPL----NL
QIDPTFQR--VRKEEREQIKNLNDKFASF------IDK--VR------------------
----FLEQKNK-MLETKWSLLQG-QKS-----SRSNM--AAMFE-SYISSLRRQLESLDQ
DKLRLEGELEN-MQALVEDLRMK-YEDEINKRTE---KENEFVLLK--K---DVDAAYMN
KVELESRLEGLTDEINFLRQLYEE-----ELRELQAQISET----SVVLSMDNNRHLDLD
GIIA-EVKAQYEEIAQ-RSKAEAESMYQIK--YEELQVRAGRHGDDLNRTKSEISEIH--
RSISRLQGE-I--DAIKA------------------------------------------
-----Q-NQ--GLKAAIADAEQ-RGELAL-KDAQAKL----EKLETALHEAKQERARQLR
EYQELLSIKLALDVEIATYRKLLEGEEN---------------------------RLE-A
---GM---Q--------KMNIHAKAVVG--------------------------------
---------------YRG---------------------GLNA-----------------
---AYK-------------------------------IMNPGVGFNGR--------DF--
--------------------------------LQ--------PIIP--------------
-PAPH-------------------NAKAVIMVKKI------ESRDGKIVSESSDVL----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------MGGI------TAITINQSLLNPI----KV
DVDPNIQ A--MCT QEKEQIKTLNNKFASF------VDK--VR------------------
----FLEQQNK-MLETKWSLLQQ-QKT-----ARSNM--DNMFE-NYINNLRRQLETLGQ
EKLKLEAELGN-MQGLVEDFKNK-YEEEINKRTE---MENEFVLIK--K---DVDEAYAN
KVELESHLEGLTDEINFLRQLYEE-----EIRELQSQISDT----SVVLSMDNSRSLDMD
STIA-EVKAQYEEIAN-RSRAEAESVYQIK--YEELQTLAGKHGDDLWRTKTEISEMN--
RNISQLQAE-I--EGLKG------------------------------------------
-----Q-RA--SLEATIEGAEH-HREQAL-KDAHAKQ----QELETALQRAKQDMVKQLH
EYQELMNVKLALDIEIATYRKLLEGKES---------------------------QLE-S
---GM---Q--------NMSIHMKTTSG--------------------------------
---------------YAD---------------------GLSS-----------------
---AYG------------------------------GLTSPSLSYGLG------------
--------------------------------SS---------FGSVT---------GSS
SFSRT-------------------SSTKAVVVKKI------ETRDGRLVSESSDVLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--M-SRQSTIT--FHSG-SRRGFSTASATTPA-----AGRS-RFSSVS-VARSTG--GSG
GLGRIS--------------------------SA------------GANFGSRSLYNLGG
T-KRVSIGGC-GGS-----FRSG-------------FGG--RA----STGFGI-----S-
--------------NGFGYG--GGVGGSF-------------------------------
--------------GGPGFP------VC--PSGGI------QEVTINQSLLTPL----NL
QIDPSIQR--VRK EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQEQGSR----TVRQSL--EPLFD-TYINDLRRQLDGITT
ERGRLEAELRN-MQEVVEDFKVR-YEDEINKRTA---AENEFVALK--K---DVDGAYMN
KVDLEAKVDALTDQVNFYRMIFEE-----ELSQMQTQVSDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEDIAN-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEISEMN--
RVIQRLRAE-I--DSVKK------------------------------------------
-----Q-CS--SLQTAIADAEQ-RGELAL-KDARAKL----VDLEEALQKAKQDMARLLR
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VS-PVNIS--------VVTSTL----------------------------------
------------SSGYGSGS--GIA-----------------------------------
---------------------------------------GGSLGFGGGSS----YSFTT-
-----------------------SG-------GHSLG--T--GLGG-------------S
GFTAS---SGRGPGG------------SGSSIKFI----STTS-----------------
------------------------------------------------------------
------------SSRKNYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MST
R--VTHKSYK--VSI--SGPGAFSSRSLTSGPS-----ARL-SF----------------
-------------------------------------------------------SRVSS
-----------------------S-----------GFRGG------------LGAGY---
--------------FG---A----------------------------------------
---------------S-----GI-------SMGGI------TAVTINQSLLNPI----KV
DVDPNIQA--VRT QEKEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQQ-QKT-----ARSNM--DNMFE-NYINNLRRQLKTLGQ
EKLKLEVELGN-MQGLVEDFKNK-YEEEINKRTE---MENEFVLIK--K---DVDEAYMN
KVELESRLEGLTDEINFLRQLYEE-----EIRELQSQISDT----SVVLSMDNSRSLDMD
GIIA-EVKAQYEEIAN-RSQAEAESIYQIK--YKELQMLAGKHGDDLRRTKTEISEMN--
RNISRLQAE-I--EGLKG------------------------------------------
-----Q-RA--SLEAAIRDAED-HGERAL-KDAHDKQ----KELEAALQRAKQDMAKQLR
EYQELMNVKLALDIEIATYRKLLEGEES---------------------------RLE-S
---GM---Q--------NMSIHTKTTSG--------------------------------
---------------YAG---------------------GLSS-----------------
---AYG------------------------------GLTSPGLSYGLG------------
--------------------------------SS---------FGSVA---------GSS
SISRT-------------------SSTKTVVVKKI------ETRDGRLVSESSDILPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MST
QTTIK---------SQT-SHCGSSASSARVPG-----LNHS-GFSCVS-LCQSRGIS---
-----G-----------------------------S----GPMCR-VASFGSRSLYSEGS
S-KRISIGGSSCGN-R-EFYGRHYG-----------------------------------
--------------GDLGIG----RGACGCFGFGA---------------------G---
-----------AGFGD-GYGGAGFP-GY--PSGGI------QEVTISQSLLIPL----NL
QIDPTIQR--VRT EEREQIKTLNNRFASF------IDK--VQ------------------
----FLEQQNK-VLDTKWALLQEQGTKT----VKPEV--ETLFE-DYINILSRRLGFTVA
EKGHLDAELRR-SQGVLEDYKYK-YEDEISKRTA---AENEFLTLK--K---DADAAFMI
ENELTAKVHSLIDEINFLRTLFDA-----EMSQMQTPLSDT----SVIISMDNNHSLDME
SIIA-EVKTQYENIAK-KSQAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEIAEIN--
RMIQRLRSE-I--DHVKK------------------------------------------
-----Q-CA--NLQAAIADAEQ-RGEMAL-KDARGKL----EGLKDAPQKAKQDRTRLQK
EYQELLSVNIYLDVEITTYRKLLEGEE--------------------------N-RFN-G
EG-IGP--V--------N---ISV-VPSTG------------------------------
------------SSGYDS----AGGA----NR----------------------------
---NHG--------------------------------------LGGGSS----HSYGRN
--HGLG-----------------------------------------------------G
GFSTG--RS-RGIG--GGLGSSSGSSST---IK-Y----TTT------------------
------------------------------------------------------------
----------SSS-RKSNRH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTQKSYK--VST--SGPRAFSSRSYTSGPG-----ARI-SSSSY-------------
-------------------------------------------------------SRVGS
S----------------------------------SFRGG------------LGGGY---
------------------------------------------------------------
-------------------GGAS-------GMGGI------TAVTVNQSLLSPL----NL
EVDPNIQA--VRT QEKEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQQ-QKT-----ARSNM--DNMFE-SYINNLRRQLETLGQ
EKLKLEAELGN-MQGLVEDFKNK-YEDEINKRTE---MENEFVLIK--K---DVDEAYMN
KVELESRLEGLTDEINFLRQLYEE-----EIRELQSQISDT----SVVLSMDNSRSLDMD
SVIA-EVKAQYEEIAN-RSRAEAESMYQIK--YEELQSLAGKHGDDLRRTKTEISEMN--
RNISRLQAE-I--ESLKG------------------------------------------
-----Q-RA--SLEAAIADAEQ-RGELAI-KDANAKL----SELEAALQRAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEES---------------------------RLE-S
---GM---Q--------NMSIHTKTTSG--------------------------------
---------------YAG---------------------GLSS-----------------
---AYG------------------------------GLTSPGLSYGLG------------
--------------------------------SS---------FGSGA---------GSS
SFSRT-------------------SSSRAVVVKKI------ETRDGKLVSESSDVLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQCT----VRS-LGRTSFSAASACIPN-----ASSS-SLCLRP-VPQAGSCGA--
-------------------------------------TTGYGRFIG--GFGSRSLHSLGE
C-QRISVAGRGGV----S-Y--GP------------------------------------
--------------AGFGTG------TGISYGFGGA------------------------
---------VA-GPFG-FGGGPGFP-AV--PVGGI------HEVSVNQSLLKPL----NL
EFHPKIKS--IRKDEKDQIQTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQGNKT----VRKNI--EPLFD-TYLNNLRRHLSSLMT
DKENLAGELSK-MHSIAEDFKNK-YEEEVNKRAD---VENEFVTLK--K---EVDTAYLD
KTKLQARLDSLTEEIDFLRALYEA-----ELSQIQSQISDT----SVILTMDNNRSLNME
GIIA-EVKAQYEEIAN-RSRAEAESWYQSR--YEELQATAGRHGDDLRNTKQEISELN--
RHIQRLRSE-I--DSVKK------------------------------------------
-----Q-VT--ALQTAITDAEH-RGELAL-KDARTKL----EDLETALQKAKADLARQLR
EYQELMNVKLALDIEIATYRKLLEGEE--------------------------C-RLS-G
EGAG-S--V--------NISVTRTTS----------------------------------
----------------GMGYGSRSCL----S-----------------------------
------------------------------------------------------------
----------------------------P-SG--------GAGGEVCAGM--------GM
GYISG--SG-Y-GTGGSCV-LG----GSSSSFKSI----STS------------------
------------------------------------------------------------
----------SSM-RGCY------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSV
H-------------F---SSQVFSSRSAAFPGR----GAQM-RPSSV----RPGA-----
----------------------------------------------FG-S--SSLYGLG-
------------TS-RPRVAV--RS-----------------------------------
---------------AYP------------------------------------------
----------------G-------P-----AGAGI------REVTINQNLLAPL----HV
DIDPSIQQ--VRQEEREQIKTLNDKFASF------IDK--VR------------------
----FLEQQNK-LLETKWALLQEQKSA-----KSSCV--PGIFE-AQIAGLRKQLEGLQM
DGGRLEVELRG-VQDLVEDFKNK-YEDEINRRTA---AENEFVVLK--K---DVDAAYMN
KVELEAKVDALNDEINFFKTLSEM-----ELTELQSQISDT----SVVLSMDNNRSLDLD
GIIA-EVRAQYEDIAN-RSRAEAEAWYQTK--FETLQAQAGKHGDDLRNTRNEIAEMS--
RAVQRLQAE-I--DNTKN------------------------------------------
-----Q-RA--KLEAAIAEAEE-RGELAL-KDAHAKQ----EELEAALQRAKQDMAGQLR
KYQELLNVKLALDVEIATYRKLLEGEE--------------------------S-RLA-G
DGVGA---V--------NIC----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTQKSYK--VS--TSGPRAFSSRCCMSGPG-----ARL-SS----------------
---------------------------------------------------------Q-V
S---------------------SS-----------DFWGG------------LGAGY---
--------------AG--------------------------------------------
-------------------TSSI-------GMGGI------TTVTINQSLLNPI----KV
DVDPNIQA--VST QEKEQIKTLNNKFASF------TDK--VR------------------
----FLEQQNK-MLEAKWSLLRQ-QKM-----ARSNM--DNMLE-SYINNLRRQLETLGQ
EKLKLEVELGN-MQGLVEGFKNK-YEEEISKCTE---MENEFVLIK--K---DVDEAYMN
KVEQKSRLQGLTDEINFLRQLYEE-----EIRELQSQISDT----SVVLSMDNIRSLDMD
SIIA-----EYEEIAN-RSWAEADSVYQIK--YEELQMLAGKHGDDLRHTKTEISEMN--
RNIS--------------------------------------------------------
-----Q-RA--SLEAAILDAED-RGNRAV-KDAHTKQ----KELEDALQQAKQDMARQLP
EYQELMNIKLALDIEIATYRKLLEGEES---------------------------RLE-S
---GI---Q--------NMSIHTKTTSG--------------------------------
---------------YAG---------------------GLSS-----------------
---AYG------------------------------GFTSPSLSYGLG------------
---------------------------------S--------SFGSGV---------GSC
SISHT-------------------SSTKAVVVKKI------ETHDGRLVS----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
MA--STSTTIR--SH-SSSRRGFSAGSARLPG-----VSRS-GFSSVS-VSRSRGSGGLG
G-------------------------------AC-----------GGAGFGSRSLYGLGG
S-KRISIGGG----SC--AISGG-------------YGS--RA----GGSYGFGG-A-G-
--------------SGFGFG--GG--A------GI-----------------GF----GL
G--GG-AGLAG-GFGGPGFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPAIQR--VRA EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWTLLQEQGTK----TVRQNL--EPLFE-QYINNLRRQLDSIVG
ERGRLDSELRG-MQDLVEDFKNK-YEDEINKRTA---AENEFVTLK--K---DVDAAYMN
KVELQAKADTLTDEINFLRALYEA-----ELSQMQTHISDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEEIAQ-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEIAEIN--
RMIQRLRSE-I--DHVKK------------------------------------------
-----Q-CA--NLQAAIADAEQ-RGEMAL-KDAKNKL----EGLEDALQKAKQDLARLLK
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLN-G
EG--VG-QV-------N-ISVVQSTI----------------------------------
------------SSGYGGASG-------------------------V-------------
---------------------------------------GSGLGLGGGSS----YS----
-----------------------YGSG--------------LGVG--------------G
GFSSS---SSRATG--GGLS--SVGGG-SSTIKYT----TTSS-----------------
------------------------------------------------------------
------------SSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSIRSTMR--TQ-SSSQRGFSASSARAPG-----GSRS-GFSCVS-VSRSRGTGGAG
G-------------------------------VY-----------GGAGFGSRSLYSLGG
T-KRISIGGG----SC--GLNSG-------------YGS--RV----GGGYGFGGGA-G-
--------------SGFGFG--AG--A------GS-----------------GF----GF
G--GG-AGF-----GGSGFP------VC--PPGGI------QEVTVNQNLLTPL----NL
QIDPTIQR--VRTEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWALLQEQGTR----TVTQSL--EPLFE-QYINNLRRQLDSILG
DRGRLDSELRS-MQSTVEDYKNK-YEDEINKRTA---AENEFVTLK--K---DVDAAYMN
KVELQAKADSLTDEINFLRTLYEA-----ELSQMQTHISDT----FVVLSMDNNRSLDLD
SIIA-EVKAQYEEIDQ-KSRAEAESWYQTK--YEELQVSASRLADDLRNTKQEISELS--
HMIQRLRSE-I--DHVKK------------------------------------------
-----Q------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTQKSYK--VST--SGPRAFSSHSYTSGPG-----ACI-SSWSF-------------
-------------------------------------------------------SRVGS
S----------------------------------SFQGG------------LGSGY---
------------------------------------------------------------
-------------------GGAS-------GMGGI------TAVTVNQRLLSPL----NL
EVDPNIQA--VRT QEKEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQQ-QKT-----ARSNM--DNMFE-SYINNLRRQLETLGQ
EKLKLEAELGN-MQGLVEDFKNK-YEDEINKRTE---MENEFVLIK--K---DVDEAYMN
KVELESRLEGLTDEINFLRQLYEE-----EIRELQSQISDT----SVVLSMDNSRSLDMD
SVIA-EVKAQYEEIAN-RSRAEAESMYQIK--YEELQSLAGKHGDDLRRTKTEISEMN--
RNISRLQAE-I--ESLKG------------------------------------------
-----Q-RA--SLEAAIADAEQ-RGELAI-KDANAKL----SELEAALQRAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEES---------------------------RLE-S
---GM---Q--------NMSIHTKTTSG--------------------------------
---------------YAG---------------------GLTS-----------------
---AYG------------------------------GLTSPGLSYGLG------------
--------------------------------SS---------FGSGA---------GSS
SFSRT-------------------SSSXGRAYKTE------SKYFDILIF----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSTKTTVR--SQT-SSHRGFSASSARVPR-----LNRS-GFSSVS-VSRSRGSGGSG
A-------------------------------VC-----------GGAGFGSRSLYGVGG
S-QRISIGGG----SC--GIGAG-------------YGG--RV----SGGFGYGGGA-G-
--------------SGFGFG--GG--A------GG-----------------AF----GF
G--GG-AGFGG-GYGGAGFP------VC--PPGGI------QEVTINQNLLTPL----NL
QIDPTIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVRQNL--EPLFE-QYISNLRRQLDGILG
ERGRLDSELRT-MQDTVEDFKNK-YEDEINKRTA---AENEFVTLK--K---DVDAAYMN
KVELQAKADSLADEINFLRALYEA-----ELSQMQTHVSDT----SVILSMDNNRSLDLD
SIIA-EVKAQYEEIAQ-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEIAEIN--
RMIQRLRSE-I--DHVKK------------------------------------------
-----Q-CA--NLQAAIADAEQ-RGEMAL-KDARSKL----EGLEDALQKAKQDMARLMK
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLN-G
EG--VG-PV-------N-ISVVQSTV----------------------------------
------------SSGYGGAS-------------------GA--G----------------
----------------------------------------SGFGLGGGSS----SYSYS-
-------------------------SG--------------HGLG--------------G
GFSSS---SGRGVG--SGLS--SAGGS-SSTVKYT----TTTS-----------------
------------------------------------------------------------
------------SSRKSYRH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

-----------------------------------------------------MNEVSWS
------------------------------------QDLQEGISCWFGPPASTPASTMSI
R--VTQKSYK--VST--SGPRAFSSRSYTSGPG-----ARI-SSSSF-------------
-------------------------------------------------------SRVGS
S----------------------------------SFRGG------------LGGGY---
------------------------------------------------------------
-------------------GGAS-------GMGGI------TAVTVNQSLLSPL----NL
EVDPNIQA--VRT QEKEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQQ-QKT-----ARSNM--DNMFE-SYINNLRRQLETLGQ
EKLKLEAELGN-MQGLVEDFKNK-YEDEINKRTE---MENEFVLIK--K---DVDEAYMN
KVELESRLEGLTDEINFLRQLYEE-----EIRELQSQISDT----SVVLSMDNSRSLDMD
SVIA-EVKAQYEEIAN-RSRAEAESMYQIK--YEELQSLAGKHGDDLRRTKTEISEMN--
RNISRLQAE-I--EGLKG------------------------------------------
-----Q-RA--SLEAAIADAEQ-RGELAI-KDANAKL----SELEAALQQAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEES---------------------------RLE-S
---GM---Q--------NMSIHTKTTSG--------------------------------
---------------YAG---------------------GLSS-----------------
---AYG------------------------------GLTSPGLSYGLG------------
--------------------------------PS---------FGSGA---------GSS
SFSRT-------------------SSSRAVVVKKI------ETRDGKLVSESSDVLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MASKSTVR--TQTSVSRRGFSTSSARLPR-----GSHS-GFSSVS-VSRSRGGAGLG
G-------------------------------AC-----------AGAGFGSRSLYGVGG
S-RRISVVGS----HS--GFSSV-------------SVS--RS----RGGAGLGGAC---
--------------------------A------GA-----------------GF----GS
R--SL-YGVGG-SRRISVFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPTIQR--VRTEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTR----PARQSL--EPLFE-QYISNLRRQLDSILG
ERGRLDSELRG-MQDLVEDYKKK-YEDEINKRTA---AENEFVTLK--K---DVDAAYMN
KVELQAKVDGLTDEINFLRAFYDA-----ELSQMQTHVSDT----SVVLSMDNNRHLDLD
SIIA-EVKAQYEDIAQ-RSRAEAEAWYQTK--YEELQVTAGRHGDDLRNTKQEIAEIN--
RMIQRLRSE-I--DHVKK------------------------------------------
-----Q-CA--SLQAAIADAEQ-RGELAL-KDARAKL----EGLEDALQKAKQDMARLLR
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VG-QV-------N-ISVVQSTV----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSF
QCS-SRSLCRS--GGG-GGGRNFSSGSAGLVS-----FQRR-STSSS--MRRSGGG----
GGGRFSG-----------------------GGFCGS---------SGGGFGSKSLVNLGG
G-RSISISVAGGG---------SS-------YG-GGFGGGSYGG------GSFGG-----
--------------GSFGGGV--G----GGFG-GGGFGG----------------GGFGS
G---------G-GFGGGRFGGGFGP-VC--PPGGI------QEVTINQSLLQPL----NV
EVDPQIQK--VKS QEREQIKSLNDKFASF------IDK--VR------------------
----FLEQQNQ-VLQTKWELLQQVDTST----RTQNL--DPFFE-SYISNLRRQVDSLKN
DQSRMDSELKN-MQDLVEEYRTK-YEDEINKRTT---AENEFVMLK--K---DVDAAYMN
KVELEAKVDALMDEINFMKMFFDA-----ELSQMQTHVSDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEDIAN-RSRTEAESWYQTK--YEELQQTAGRHGDDLRNTKHEISEMN--
RMIQRLRSE-I--DNVKK------------------------------------------
-----Q-CA--NLQNAIAEAEQ-RGELAL-KDARNKL----TELEEALQKAKQDMARLLR
EYQELMNTKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EGVG-P--V--------NISVVTNSLSS-G------------------------------
------------YGGRSNIGYGSGLG-----SGIGGFASDIG------------------
-----------------------PL-------------------LNRRGL-G--------
SGLSVGGS-----------------------------------------GFSASSGQ-G-
--------------GGFSSGGG-----SSSSVKFV----STT------------------
------------------------------------------------------------
----------SSS-RRSFKS----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTQKSYK--VS--TSEPRAFSSRFYTSGPS-----AHI-SSS---------------
---------------------------------------------------------MGS
-----------------------S-----------SFRGG------------LGR-----
---------------GYG------------------------------------------
-----------------GASG----------MGGI------TTVTVNQSLLSPL----KL
E------A--VRT QEKEQIKTLN-KFASF------IDK--IR------------------
----FLEQQNK-MLETKWSLLQQ-QKM-----AQSNM--DNMFG-SYINNLTRQLETLGQ
EKLKLEVELGN-MQVLVEDFKNK-YEDEINKLTE---MENEFVLIK--K---EVDEAYMN
KVELGSRLEGLTDEINFLRQLYEE-----EIRELQCQISDT----S--------PSLDMD
SIIT-EVKVQYEEITN-HSQAEAESMYQIK--YEELQTLVGKRGDDLRHTKTEISEMN--
RNISRLQAE-T--EGLKG------------------------------------------
-----Q-RT--SLEAAIADAEQ-RGELAV-KDANAEL----WELEAAQEGAKQDMARPLH
EYQELMNVKLALDIQIATYRKLLEGDES---------------------------RLE-S
---GM---L--------NMSIHTKTTSS--------------------------------
---------------YAG------------------------------------------
---AFG------------------------------GLTSPGLSYSLG------------
---------------------------------S--------SFGSGA---------GSI
CFSST-------------------GSTRAVVVKKI------KTRDGKLE--SSDVLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTQKSYK--MST--SGPRAFSSRSYTSGPG-----ARI-SSSSF-------------
-------------------------------------------------------SRVGS
G----------------------S-----------SFRGS------------LGSSM---
--------------GL---S----------------------------------------
---------------GSY-GGAG-------GVGGI------TAVTVNQSLLSPL----KL
EVDPNIQA--VRT QEKEQIKTLNNKFATF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQQ-QKT-----ARSNM--DNMFE-NYINNLRRQLESLGQ
EKLKLEAELGN-MQGLVEDFKNK-YEDEINKRTE---MENEFVLIK--K---DVDEAYMN
KVELESRLEGLTDEINFLRQLYEE-----EIRELQSQISDT----SVVLSMDNSRSLDMD
GIIA-EVKAQYEDIAN-RSRAEAESMYQIK--YEELQTLAGKHGDDLRRTKTEISEMN--
RSISRLQAE-I--EALKG------------------------------------------
-----Q-RA--SLEAAIADAEQ-RGEMAI-KDANAKV----AELEAALQRAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEES---------------------------RLE-S
---GM---Q--------NMSIHTKTTSG--------------------------------
---------------YSG---------------------GLNT-----------------
---SYG------------------------------GLSSPGLNYGLSSF-------Q--
--------------------------------PN---------FSSAG---------GSS
SFSRT----------------------KAVVVKKI------ETRDGKLVSESSDVLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
----------------------------------------------------------MR
-SSVSRQTYST--------RGGFSSNSASAG---GGSRARS-SFSSVT-VSRSSGSGGG-
--------------------------T--------------RCGPGKGGFGSRSLYNLGG
S-KSISVSVAGGASSG-RAL----------------------------------------
--------------GGFSFG------------------SGAFA-----------------
-------GLG-------AGRQVFGP-AC--PPGGI------QEVTVNQSLLTPL----NV
EIDPEIQR--VRTQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQGQNSG--VTRNNL--EPLFE-NYLGNLRRQLDNLQS
DRGRLDSELRN-VQDVLEDFKSK-YEDEINKRTA---AENEFVLLK--K---DVDAAYMS
RMDLQGKASTLTEELDFLNHLYEM-----ELSQVQTHVSDT----NVVLSMDNNRSLDLD
SIIA-EVKAQYELIAQ-RSRAEAEAWYQTK--YEELQVTAGKHGDNLRDTKNEIAELT--
RTVQRLQGE-V--DAVKK------------------------------------------
-----Q-CQ--QLQTAIAEAEQ-RGDMAL-KDAQKKL----GDLDMALHQAKEDLARLLR
DYQALMNVKLALDVEIATYRKLLESEE--------------------------S-RMS-G
ECPSA---V--------SISVTGNSTTVCG------------------------------
-----------------GG--------------AAGFGGGMSLGGG---GG--AGKGGFG
TS----------------------------------------VGYGT----------V--
KGGPVSG--GTSILRKT--TTVKTSSRRY-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
----------------------------------------------------------MR
S-SLSRQTFST--------KGGFSSNSASGG---GGSRMRT-SYSSVT-MSRGS--GGG-
--------------------------G---GV---------RSGSSSGGFGSRSLYNLGG
--KNISVSMACGASSG-RAL----------------------------------------
--------------GGFG--------------------SGAYV-----------------
-------GLG-------ASRQTFGP-VC--PPGGI------QEVTVNQSLLTPL----NV
EIDPEIQR--VRT QEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQSQNTG--VAR-SL--EPFFE-NYLSTLRRQLDTKQS
ERGRLDMELRN-VQDNLEDFKNK-YEDEINKRTA---LENEFVLLK--K---DVDAAYMG
RMDLHGKVDSLTQEIDFLQQLFEM-----ELSQVQTNVSDT----NVILSMDNNRNLDLD
SIIA-EVKAQYELIAQ-KSRAEAESWYQTK--YEELQVTAGKHGDSLRDTKNEIAELT--
RTTQRLQGE-V--DAAKK------------------------------------------
-----Q-CQ--QLQTAIAEAEQ-NGEMAL-KDAKKKL----GDLDTALHQAKEDLARMLR
EYQDLVSVKLALDMEIATYRKLLESEE--------------------------S-RMS-G
DCPSA---I--------SISVTGNSTSVCA------------------------------
-----------------GG--------------TAGFGNGLSLGGA---GG--ASKGGFG
SS----------------------------------------VSYGA----------A--
KGGQVSG--GTSILRKT--TTVKTSSRRY-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MIARQQCVR-----G-RSRGFSCGSAV-VGG----GKRA-AFSSFS---VSGGT----
-----------------------------------------GRCS-SGGFGSRSLYNLGG
R-KSIAISMAGSRQ-GA-GFGSAGG-----------FGPGS-------------------
-------FG-------------------------AGFGAGNFG-----------------
---SGFGG----SFS--GRGGPAFP-AC--PAGGI------QEVTINQSLLTPL----HV
EIDPEIQK--VRTEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQQQTTTT----SSKNL--EPLFE-AYISALRKQLDTLVN
DKGRLQSELKT-TQDSVEDFKTK-YEDEINKRAA---AENDFVVLK--K---DVDAAYMS
KVELEAKVDALNDEINFLRVLFAA-----ELSQMQTHVSDT----SVVLSMDNNRDLDLD
SIIA-EVRAQYEEIAQ-KSKAEAEALYQTK--VQQLQISVDQHGDNLKNTKSEISELN--
RLIQRLRAE-I--ENVKK------------------------------------------
-----Q-CQ--TLQASVADAEQ-RGELAL-KDAYSKC----TELETALQKAKEELARMLR
EYQELLSVKLALDVEIATYRKLLEGEE--------------------------C-RMS-G
ERQSA---M--------SISVVSGGASTGG------------------------------
---------------IG-GG---LGS----C---SGFG--LGS-----------------
---------------------------------GFGSG--SGSGFGF--G-GG-------
----VCGSSGSKIISTTTMTKRS--HR---------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
--------------------------------------------------------MS--
--------------R----SVSFSSRSVAVP-G----VSQV-RVSSV-------------
-----------------------------------SSVRGGGSLSKAGGFGSSSLYNLGS
ANKRISLGGS--------SSYSVRS-----------------------------------
---------------GYGYG-------GM-------------------------------
------------GF------GGAIA-----PSAGI------QEVTVNQSLLTPL----NL
EIDPNIQR--VRK EEKEQIKTLNNRFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQDQKTT-----RS-NI--VPMFE-AYITNLRRQLDGLLN
DKGRLEGELRN-MQDLVEDFKAK-YEDEINKRTT---AENEFVVLK--K---DVDAAYMN
KVELEAKVDALTDEINFLRSLYEA-----ELRELQAQISDT----SVVLSMDNSRNLDLD
SIIA-EVKAQYEDIAN-RSRAEAESWYQSK--FEALQVTAGKHGDDLRNTKNEITEIN--
RVIQRLQGE-I--ENAKA------------------------------------------
-----Q-RA--KMEAAIAEAEE-RGELAV-KDARAKL----EELEAALQKAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEE--------------------------S-RLA-G
DGVGS---V--------NISMVSSSGGG----SS--------------------------
-G----FL-G----------------------------GGVRGGLALGAGM-GSGALGFS
S-------G-GS------------------------------------------------
--------TKSYTVTTTSS-TRSFRK----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

MTSVGVF----------DMFSRCKKDGPVPKAKPRGVSDFSLYAPATKPCS---------
------------------------CTYKRPRTAVAVSGLA--------LLASLTALSVLS
PAMLIRQQCVR-----G-GPQGFSCGSAI-VGG----GKKP-AFSSIS---MSGGT----
-----------------------------------------GSCS--GGFSSRSLCNLGG
N-KSISIGTAGCWR-GA-GFGAAGG-----------------------------------
------------------------------------LGAGCFG-----------------
---LGFGG----SFG--GRGGAGFP-VC--PAGGI------QEVTINQSLLTPL----HM
EIDPEIQK--VRTEEREQIKTLNDKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQQQATTT----SSKNL--DPLFE-AYLSALRKQLDTLTN
NKGGLQYELKI-MQDSVEDFKAK-YEDEINKRTA---AENDFVVLK--K---DVDATYMN
KAELEAKVEARNDEINFLRVLYAA-----ELSQMQTHVSDM----SVVLSMDNNRNLDLD
GIIA-EVKAQYEDIAQ-RSKAEAEALYQTK--VQQLQASVEQHGDSLKSTKIEISELN--
RMIQRLQAE-I--ENVKK------------------------------------------
-----Q-CQ--TLQASVAGAEQ-RGEAAL-KDAHGKR----TEMEGALQKAKEELVRMLQ
EYQELMSVKLALDIEIATYRKLLEGEE--------------------------C-RMS-G
ECQSA---V--------SISVAGGAASAGG------------------------------
---------------VG-GG---LGS----C---SGFG--LG------------------
------------------------------------SG--SGSGFGFGGS-VG-------
----VGGSSSSKIISTTTLAKRS--HR---------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSCKSTVK--TK-TISCRGFSAGSARLPG-----VCRS-GFSSVS-LSRSRGSGGLA
G-------------------------------VC-----------GGAGFGSRSLYGLGG
S-KRISIAGG----GC--VIGGG-------------YGG--RI----GVGYGFGGGA-G-
--------------SGIGFG--AG--A------GS-----------------GF----GL
G--GG-AGFGG-GYGGYGFP------VI--PPGGI------QEVTVNQSLLTPL----NL
QIDPTIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTR----TVRQNL--EPLFE-QYINNLRRQLDSILG
ERGRLDSELRG-MQDTVEDFKNK-YEDEINKRTA---AENEFVKLK--K---DVDSAYMN
KVELQAKVDALTDEINFLRTFYDA-----ELAQMQSYISDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEEIAQ-RSQAEAESWYQSK--YEELRVTAGRHGDDLRNTKQEISEIN--
RVIQRLRSE-I--DHVKK------------------------------------------
-----Q-CA--SLQSAIADAEQ-RGELAL-KDARNKL----ADLEDALQKAKQDMARLLK
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--AG-QV-------N-ISVVQSTV----------------------------------
------------SSGYG-----------------------G--ASGL-------------
---------------------------------------SSGLGIGGGSG----CS----
-----------------------YS----------IG--G--------------------
GFSSG---SGRAIG--GGYG--SSGGS-SSTIKYT----TS--SC---------------
------------------------------------------------------------
------------SSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
H-------------F---SSPVFTSRSATFSGR----GAQV-RLSSA----RPGG-----
----------------------------------------------LG-S--SSLYGLG-
------------AS-RPRVAV--RS-----------------------------------
---------------AYG------------------------------------------
----------------G-------P-----VGAGI------REVTINQSLLAPL----RL
DADPSLQR--VRQ EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-LLETKWTLLQEQKSA-----KSSRL--PDIFE-ALIAGLRGQLEALQV
DGGRLEAELRS-MQDVVEDFKNK-YEDEINRRAA---AENEFVVLK--K---DVDAAYMG
KVELEAKVDALNDEINFLRTLNET-----ELTELQSQISDT----SVVLSMDNSRSLDLD
GIIA-EVKAQYEEMAK-CSRAEAEAWYQTK--FETLQAQAGKHGDDLRNTRNEISEMN--
RAIQRLQAE-I--DNIKN------------------------------------------
-----Q-RA--KLEAAIAEAEE-RGELAL-KDARAKQ----EELEAALQRAKQDMARQLR
EYQELMSVKLALDIEIATYRKLLEGEE--------------------------S-RAL-W
G-------L--------GLDIHPFTSI---------------------------------
-SSVVNST-GG-----SSSG----------------GGIGLTLGG-----TMGSNALSFS
SS-----AGPGP------------------------------------------------
--------LKAYSIRTTSASRRSARN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQSSVS--FR-SGGSRGFSTASAITPS-----VSRT-SFTSV---SRSGGG-GGG
GFGRVS--------------------------LG-------GAGGV-GGYGSRSLYNLGG
S-KRISISTS----GG--NFRNR-------------FGAG--A----GGGYGFGGGA-G-
--------------GGFGFG--GGAG--------G-----------------GF----GL
G--GGA-GFGG-GFGGPGFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPTIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVRQNL--EPLFE-QYINNLRRQLDSIVG
ERGRLDSELRN-MQDLVEDFKNK-YEDEINKRTT---AENEFVMLK--K---DVDAAYMN
KVELEAKVDALMDEINFMKMFFDA-----ELSQMQTHVSDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEEIAN-RSRTEAESWYQTK--YEELQQTAGRHGDDLRNTKHEISEMN--
RMIQRLRAE-I--DNVKK------------------------------------------
-----Q-CA--NLQNAIADAEQ-RGEMAL-KDARNKL----AELEDALQKAKQDMARLLR
EYQELMNTKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VG-PV-------N-ISVVTSSV----------------------------------
------------SSGYGGGS-G--------------LGG--GLGGGLGGG----L-----
-----GGGLGG------------------------------------GST----SYYSS-
------------------------SSG-----GAGLG--SGLSVGG-------------S
GFSTS---SGRGMGVGFGS---GG-G-SGSSVKFV----STTS-S---------------
------------------------------------------------------------
-------------SRKSFKS----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MNRQFCKK--SF-SGRSQGFSGGSAVVS-S-----SSR-M-SC---VARSGGV-G--
-----GG-------------------------ACGFR----SGA---GGFGSRSLYNLGG
N-KSISISVAAGGS-RAGGFVGGQS------SCG--FAGGYGGG----FGGSYGGGFGGG
--R--GIGSGFG-------------------------------GAGGFGGAGGFGGPGVF
GGLGSFGSPG--GFV----P------GG--FPGGI------QEVTVNQSLLQPL----HV
EIDPQIGQ--VKA QEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWELLQQQTTG----LGPSSL--EPCFE-SYINFLRKQLDSLLA
ERGNLEGELKS-MQDLVEDFKKK-YEDEINKRTA---AENEFVGLK--K---DVDAAFMN
KVELQAKVDSLTDEVSFLRTLYEM-----ELSQMQSHVSDT----SVVLSMDNNRCLDLD
NIIA-EVRAQYEEIAQ-RSKAEAEALYQSK--LGELQTTAGRHGDDLKNTKSEIMELN--
RMIQRLRAE-I--ENVKK------------------------------------------
-----Q-NA--NLQTAISEAEQ-RGEMAL-KDANAKL----QDLQAALQKAKDDLARLLR
DYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RMS-G
ECQSA---V--------CISVVSNVTST--------------------------------
---------SGSSGSSRGVFGGVSG------S--GGYRGGGSSSG---------------
--------------------SSS-GYGVSG---------GSSSGYGGVSS-GS---TG--
GR-GSSGGYQ--------------------SSSS------GSMLGGAGSMS---MSHSGM
GSSSG--SV-QTSGGSGYKS----GGGGSTNIRFS----QTT------------------
------------------------------------------------------------
----------SSS-QHNSTK----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTQKSYK--VS--TSGPQAFSSLSYTSGPG-----ACI-SSSSF-------------
-------------------------------------------------------SRVDS
-----------------------S-----------SFWSG------------LGG-----
---------------GCG------------------------------------------
-----------------RASG----------MGGI------TAVTVNQSLLSPL----NL
EMNRNI QA--MYS QENEQIKSLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQQ-QKT-----VWSNM--DNVFE-SYINNLRRQLETLGQ
EKLKLEAELGN-MQGLVEDFKNK-HEDEINKRTE---MENEFVLIE--K---AVDEAYMN
KVELESPGKGWLTRS-------AS-----SDWELQSQVLDT----SVVLSIYNSRFLDMD
SIIT-EVEAQYEEIAN-RSWTEAESMYQIK--YKELLTL------------TEISEIN--
WNISGLQAK-I--EGLKG------------------------------------------
-----Q-RT--SLEAAITHLAI--------KDANAKL----SELEWAKQ----YM-----
------------------AQKLLEGEES---------------------------WLE-S
---GM---Q--------NMSIHMKITSS--------------------------------
---------------YVG---------------------GQSL-----------------
---AFG------------------------------GLTSPGLSYSLG------------
---------------------------------S--------SFVCGV---------GSS
SFSCT-------------------SSSR-FVVVKN------ETRDGKLVSESSNVLRK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
-------------------------------------------------PASTPASTMST
R--VIQKSYK--VP--ASGPRAFSSRSYTSGPG-----AHI-SSSSF-------------
-------------------------------------------------------SQVGS
-----------------------S-----------SFRDG------------MGG-----
---------------GYG------------------------------------------
-----------------GVSG----------MGSI------TT-----------------
--------------EKKQIKTLNNKFASF------IDK--VQ------------------
----F-EQQTK-MLETKWSLLQQ-QKM-----AQSNM--DNMFE-SYINNLRRQLETLGQ
EKLKPEAELGYMMQGLVEDFKNR-YEDEINKCTE---MENEFVLIK------DVDEAYMN
KVELESRLEGLTDQISFLRQLYEE-----GIRECSPSPNLD----HILVCYGHSRSLDMD
SITA-EIKAQYEEIAN-RSWAEAESMYQIK--YEELQTLAGKHGDDPGHTKTEFSEMNIS
PNISWLQAE-I-------------------------------------------------
-----E-RA--SLEAAIADAKQ-RGELAV-EDAKAKL----SELEAALKRAKQDIARPLR
EYQELMNVKLALDIEIATYRKLLEGEES---------------------------RLV-S
---GM---Q--------NMSTHRKTT----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTLKSYR--VS--TSGPGAFSSRSFMSGPS-----ARS-NSLSY-------------
--------------------------------------------------------SR-V
S---------------------ST-----------GFRGG------------LGAGY---
--------------AG--------------------------------------------
-------------------ASGI-------GMGGI------TAVTINQSLLNPI----KL
DVDPNIQA--VCT QEKEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWNLLQQ-QKM-----ARSNM--DNMFE-SSINNLGWQLETLGQ
EKLKLEAELGN-MQGL----------EEINKRTE---MENEFVLIK--K---DVDEAYMN
KVELESLLEGLTDEISFLRQLFEE-----ETRELKSQISDT----SAVLSMDNSRSLDVD
SIVA-EVKAQCQEIAN-GSRAEAESVYQIK--YEELQTLAGKHGDDLWRTKTEISEMN--
RNISWLQAE-T--EGLKG------------------------------------------
-----Q-RA--SLEAAIIDAEH-RGEQAL-KDARAKR----QQLE----DAKQDMARQLR
DYQELMNVKLALDIEIATYRKLLEGEES---------------------------RLE-S
---GM---Q--------NMSIHRKTTSG--------------------------------
---------------SAG---------------------GLSS-----------------
---AYG------------------------------DLTSPGLSYSLG------------
---------------------------------S--------SFGSGG---------GS-
TFSRT-------------------SSTKAVVVKKI------ETHNGRLVSESSDVLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
----------------------------------------------------------MR
-SSISRQTYST--------KGGFSSNSASGG---SGSQART-SFSSVT-VSRSSGSGGG-
--------------------------A--------------RCGPGTGGFGSRSLYNLGG
H-KSISVSVAGGASSG-QAL----------------------------------------
--------------GGFGFG------------------SRAFM-----------------
-------GQG-------AGRQTFGP-AC--PPGGI------QEVTVNQSLLTPL----HV
EIDPEIQR--VRTQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQGQNLG--VTRNNL--EPLFE-AYLGSMRSTLDRLQS
ERGRLDSELRN-VQDLVEDFKNK-YEDEINKRTA---AENEFVVLK--K---DVDAVYMG
WMDLHGKVGTLTQEIDFLQQLYEM-----ELSQVQTHVSDT----NVVLSMDNNRNLDLD
SIIA-EVKARYELIAQ-RSRAEAEAWYQTK--YEELQVTAGKHGDNLR------------
------------------------------------------------------------
-------CQ--QLQMAIADAEQ-HGELAL-KDAQKKL----GDLDVALHQAKEDLTRLLR
DYQELMNVKLALDVEIATYRKLLESEE--------------------------S-RMS-GECPSA---V--------SISVTGNSTTVCG-----------------------------------------------GG--------------AASFGGGISVGGS---GG--ATKGGFSTK----------------------------------------VGYST----------V--KGGPVSG--GPCILRKT--TTVKTSSQRY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CQ--QLQMAIADAEQ-HGELAL-KDAQKKL----GDLDVALHQAKEDLTRLLRDYQELMNVKLALDVEIATYRKLLESEE--------------------------S-RMS-G
ECPSA---V--------SISVTGNSTTVCG------------------------------
-----------------GG--------------AASFGGGISVGGS---GG--ATKGGFS
TK----------------------------------------VGYST----------V--
KGGPVSG--GPCILRKT--TTVKTSSQRY-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--ETQKSYK--VS--TSGPRAFSSRSYTSGPG-----ARI-SSSSF-------------
-------------------------------------------------------SRVGS
-----------------------S-----------SFRGG------------LGG-----
---------------GYG------------------------------------------
-----------------GASG----------MGGI------TAVTVNQSLLSPL----NL
EVDPNIQA--VRT QEKEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQQ-QKT-----ARSNM--DNMFE-SYINNLRRQLETLGQ
EKLKLEAELGN-MQGLVEDFKNK-YEDEINKRTE---MENEFVLIK--K---DVDEAYMN
KVELESRLEGLTDEINFLRQLYEE-----GIR----------------------------
------------------------------------------------ELHRSLDMDK--
RNISRLQA----------------------------------------------------
-------EA--SLEAAIADAEQ-RGELAI-KDAITKL----SELEAALQWAKQDMVRQLR
EYQELMNVKLALDIEI---------------------------------------RLE-S
---GM---Q--------NMSIHTKTTSG--------------------------------
---------------YAG---------------------GLSS-----------------
---AYG------------------------------GLTSPGLSYGLG------------
---------------------------------S--------SFGSGE---------GSS
SFSRT-------------------SSSRAVVVKKI------ETRDGKLVSESSDVLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------ALALLS
PAMIAKQQWVR-----G-GSRGFSCGSA--TGG----GRKS-AFSSFS---VSAGA----
-----------------------------------------GRCS-SGGFGSRSLYSLGR
N-KSLSISGAGSRQ-GA-GFGGAGG-----------FGA---------------------
-------------------------------------APGGFG-----------------
---GAFGG----SFN--GRGGPGFP-VC--PAGGI------QEVTINQNLLTPL----HV
EIDPEIQK--VRTEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-ILETKWKLLQQQTTTT----SSKNL--EPLFE-SYIIILRKQVEGLNN
DKGRLQSELKV-MQDSVEDFKTK-YEDEINKRTA---AENDFVVLK--K---DVDAAYMT
KVELEAKVDALTDEINFLRTLYEA-----ELTQMQTQVSDT----SVVLSMDNNRCLDLD
SIIA-EVKAQYEEIAQ-KSKAEAEAWYHIK--VQQLQGSVDQYGDSLR-TQSEISELN--
RMIQRLRAE-I--ENV-K------------------------------------------
-----Q-CQ--TLQASVADAEE-HGELAL-KDARSKQ----TELEVALQQGKEEPARMLR
EYQELMSVKLALDVEIATYRKLLEGEE--------------------------C-RMS-G
ECQSS---V--------SISMVGGGTSVGG------------------------------
---------------IG-GG---LGS----C---SGFG--LGG-----------------
---------------------------------GFGSG--SGSGFGF--G-GG-------
----VCGSSGSKIISTTTLTKRS-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTQKSYK--VS--TSGARGFSSHSYMSGPG-----ACI-SSMSF-------------
-------------------------------------------------------SRVGS
-----------------------R-----------SFQGG------------LGR-----
---------------GYG------------------------------------------
-----------------GASG-----------GGI------TTITVNQSLLSPL----KL
VVDPNIQA--MRTQE-EQIKTFNNKFASF------IDK--VQ------------------
----YLKQQMM-MLETKWSLLQQ-HKM-----AWSNM--DNMLE-NYINNLRRQLETLGQ
EKLKLEAELCN-MQGLVEDFKNN-YEDELNMRTE---MENAFVLIK--K---DVDETYMN
KVELESRLEGLTDEISFLRQLYEE-----EIQELQSQISDTSTDTSMVLSMDNSHSLDMD
SIIA-EVKAHYEETAN-RSQAEAESMYQIK--YENLQTLAGKHGDDLRCPKTENSQTN--
WNISRFRAE-I--EGLKG------------------------------------------
-----Q-RA--SLEATIADAEQ-PGELAV-KDANAKL----SELEAAP-AAGQDLVWQLR
ESPELMNVKLAPDIEIATYRKLLEGEES---------------------------QLE-S
---GM---Q--------NMSIHMKTTSG--------------------------------
---------------YAG---------------------GLSL-----------------
---ASG------------------------------GLTKLSLG----------------
---------------------------------------------YGK---------GSS
SFSCT-------------------SSIRAMVVKKI------ETRDGKLVSESSDVLSK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
----------------------------------------------------------MR
-SSVSRQTYSI--------KGGFSSNSASGG---GGSQART-SFSSVT-VSRNSGSGGG-
--------------------------A--------------RCGPSTGGFGSRSLYNLGG
H-KSISVSVAGGSSSG-WAL----------------------------------------
--------------GGFGFG------------------SRAFT-----------------
-------GQG-------AGRQTFGP-AC--PPGGI------QEVTVNQSLLTPL----HV
EIDPEIQR--VRTQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQGQNLG--VTRNNL--EPLFE-AYLGSMRSTLDRLQS
ERGRLDSELRN-VQDLVEDFKNK-YEDEINKRTA---AENEFVVLK--K---DVDAAYMC
RMDLHGKVGTLTQEIDFLQQLYEM-----ELSQVQTHVSDT----NVVLSMDNNRNLDLD
SIIA-EVKAQYELIAQ-RSRAEAEDWYQTK--YEELQVTAGKHGDNLRDTKNEIAELT--
RTIQRLQGE-V--DAAKK------------------------------------------
-----Q-CQ--QLQTAIEEAEQ-RGELAL-KDAQKKL----GDLDVALHQAKEDLARLLR
DYQELMNVKLALDVEIATYRKLLESEE--------------------------S-RMS-G
ECPSA---V--------SISVTGNSTTVCG------------------------------
-----------------G---------------------GIALGGN---GG--ATKGGFS
TN----------------------------------------VGYST----------V--
KGGPVSG--GTSILRKT--TTVKTSSRRY-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------GFGSRSLYNLGG
S-KRISISTS----GG--GFRSQ-------------FGASAGG----G--YGFGGGA-G-
--------------SGFGFG--GGAG-G------------------------GF----GL
G--GGAGFG-G-GYGGAGFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPTIQR--VRTEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVRQSL--EPLFE-QYINNLRRQLDSILG
ERGRLDSELRN-MQDLVEDFKNK-YEDEINKRTT---AENEFVMLK--K---DVDAAYMS
KVELEAKVDALMDEINFMKMFFDA-----ELSQMQTHVSDT----SVVLSMDNNRSLDLD
SIIS-EVKAQYEEIAN-RSRTEAESWYQTK--YEELQQTAGRHGDDLRNTKHEISEMN--
RMIQRLRSE-I--DNVKK------------------------------------------
-----Q-CA--NLQNAIADAEQ-RGELAL-KDARNKL----TELEEALQKGKQDMARLLR
EYQELMNTKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VG-PV-------N-ISVVTNSV----------------------------------
------------SSGYGG-S--SFGG----G---SGFGGGSGFGGGLGGG----L-----
-----G----------------------------------------GGGS----SSFYS-
-----------------------SSS------GGGMS--SGLSMGG-------------G
GFSAS---SGRGM--GFGS----GGG-SSSSVKFV----STTS-S---------------
------------------------------------------------------------
-------------SRRSYKS----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------VLDTKWTLLQEQGTK----TVRQNL--EPLFE-QYINNLRRQLDSILG
ERGRLDTELRG-MQDMVEDFKNK-YEDEINKRTA---AENEFVTLK--K---DVDAAYMN
KVELQAKVDALMDEINFTRALYEA-----ELAQMQTHISDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEEIAQ-KSRAEAESWYQSK--YEELQVTAGRHGDDLRNTKQEIAEIN--
RMIQRLRSE-I--DHVKK------------------------------------------
-----Q-CA--NLQSAIADAEQ-RGEMAL-KDAKNKL----ADLEDALQKAKQDMARLLK
EYQELMNVKLALDVEIATYRKLLEGEECL---------------------------GG-G
S-----------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------G----YSYG--
-------------------------S--------------GHSLG--------------A
GFSSS---SGRGIG--GGFS--SSGG-SSSTIKYT----TTSS-----------------
------------------------------------------------------------
------------STRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------P------VC--PPGGI------QEVTINQNLLTPL----NL
QIDPTIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVRQNL--EPLFE-QYINNLRRQLDSILG
ERGRLDTELRG-MQDMVEDFKNK-YEDEINKRTA---AENEFVTLK--K---DVDAAYMN
KVELQAKVDALMDEINFTRALYEA-----ELAQMQTHISDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEEIAQ-KSRAEAESWYQSK--YEELQVTAGRHGDDLRNTKQEIAEIN--
RMIQRLRSE-I--DHVKK------------------------------------------
-----Q-CA--NLQSAIADAEQ-RGEMAL-KDAKNKL----ADLEDALQKAKQDMARLLK
EYQELMNVKLALDVEIATYRKLLEGEECL---------------------------GG-G
S-----------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------G----YSYG--
-------------------------S--------------GHSLG--------------A
GFSSS---SGRGIG--GGFS--SSGG-SSSTIKYT----TTSS-----------------
------------------------------------------------------------
------------STRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--M-SRQSSIT--FQSG-SRRGFSTTSAITPA-----AGRS-RFSSVS-VARSAA--GSG
GLGRIS--------------------------SA------------GASFGSRSLYNLGG
A-KRVSISGC-GSS-----FRSG-------------FGG--RA----SNGFGV-----N-
--------------SGFGYG--GGVGGGF-------------------------------
--------------SGPSFP------VC--PPGGI------QEVTVNQSLLTPL----HL
QIDPAIQR--VRA EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQGSR----TVRQNL--EPLFD-SYISELRRQLESVTT
ERGRLEAELRN-MQDVVEDFKVR-YEDEINKRTA---AENEFVALK--K---DVDAAYMN
KVELEAKVKSLPEEINFIHSVFDA-----ELSQLQTQVSDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEDIAN-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEISEMN--
RTIQRLRAE-I--DSIKK------------------------------------------
-----Q-CS--SLQTAIADAEQ-RGELAL-KDARAKL----VDLEEALQKAKQDMARLLR
EYQELMNIKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VS-PVNIS--------VVTSTL----------------------------------
------------SSGYGRGS--SIG-----------------------------------
---------------------------------------GGNLGLGGGRG----YSFTT-
-----------------------SG-------GHSLG--A--GLGG-------------S
GFSAT---SNRGLGG------------SGSSVKFV----STTS-----------------
------------------------------------------------------------
------------SSQKSYTH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MTQRSSV---TIKSGGTRNFSASSASLLP-----GCRP-SFSSVS-VSQGGKS----
-----------------------------------------FGGGFGGGFGTRSLHSFGG
S-KRISIS---GGY-RSN-RASGG----------------GAGY-----G--LGLGGMG-
-------YRVGGAFGGYGFG----------------------------------------
----------------------AGM-MP--GSGGI------QEVTVNQSLLTPL----HL
EIDPSLQR--VRK EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWSLLQEH--KT----TRANI--EPMFE-AYISNLRRQLDCLGG
ERARLETELKN-MQDVVEDFKNK-YEEEINRRTV---AENEFVVLK--K---DVDAAYMN
KVELEAKVDALMDEINFLRAFYDA-----ELAQLQAQISET----SVVLSMDNNRKLDLD
SIIS-EVKAQYEDIAN-RSRAEAESWYQIK--YEELQRSAGRHGDDLRTTKMEISELN--
RVMQRLRSE-I--DNLKK------------------------------------------
-----Q-CT--TLQSAIADAEQ-RGELAL-KDAKHKL----AELEDALQKAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEE--------------------------C-RGE-C
QRALCL--L--------STAVVSSTGGTGY------------------------------
------------SAG-------GGGL----CVAGGSYSSSLGY------GGG--------
------------------------------------------------------------
-----------------------------------------------------------G
GFSST--SG-R--------SMS----GSSSSMRII----SKT------------------
------------------------------------------------------------
----------SS--TKKSYRS---------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--M-SRQSTVT--FH-SGSRRGFSTASATTPT-----AGRS-RFSSVS-VARSSG--NSG
GLGRIS--------------------------GI------------GSGFGSRSLYNLGA
T-RPVSVGGCAGSG-----FRSG-------------FGG--RA----SSSFG--------
------------------------YGGGF-------------------------------
--------------GGPGFP------VC--PSGSI------QEVTVNQSLLTPL----NL
QIDPTIQR--VRKEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQEQGSR----TVRQNL--EPFFD-AYVNDLRRQLDSVTA
ERGRLDAELRH-MQEVVEDFKVR-YEDEINKRAA---AENEFVGLK--K---DVDGAYMN
KVELEAKVDSLTDQINFYRMVYEA-----ELSQMQNQVSDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEDIAN-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEISEMN--
RMIQRLRSE-I--DAVKK------------------------------------------
-----Q-CS--SLQTAISDTEQ-RGELAL-KDARAKL----VELEDALQKAKQDMARLLR
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VS-PVNIS--------VVTSTV----------------------------------
------------SSGYGGGT--NIG-----------------------------------
---------------------------------------GGSLGLGGNSG----YSFTT-
-----------------------TG-------GHSLG--T--GLGG-------------S
GFTTS---SSRGPVG------------SGSSIKFV----SSTS-----------------
------------------------------------------------------------
------------SSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MNRQICKK--SF-SGGSQGFSGRSAVVS-S-----SSR-I-SC---VARSWGV-G--
-----GG-------------------------ACGFR----SRA---GGFGSRSLYNLGS
N-KSI----SAGGS-RAGGFVGGQS------SCG--FAGGYGGG----FGGSYGGGFGGG
--R--GIGSGFG-------------------------------GAGGFDGAGSF------
GGPGVFGGLG--SSGS---PGGFVP-GG--FPGGI------QEVTVNQSLLQPL----NV
EIDPQIGQ--VKA QEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWELLQQQTTG----LGPSSL--EPCFE-SYISFLRKQLDSLLA
ERGNLEGELKS-MQDLVEDFKKK-YEDEINKRTA---AENEFVGLK--K---DVDAAFMN
KVELQAKVDSLTDEVSFLRTLYEM-----ELSQMQSHVNDT----SVVLSMDNNRCLDLD
NIIA-EVRTQYEEIAQ-RSKAEAEALYQTK--LGELQTTAGRHGDDLRNTKSEIMELN--
RMIQRLRAE-I--ENVKK------------------------------------------
-----Q-NA--NLQTAISEAEQ-RGEMAL-KDANAKL----QDLQAALQKAKDDLARLLR
DYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RMS-G
ECQSA---V--------CIWVS--------------------------------------
------------------------------------------------------------
---------------------------------------------------SG---ST--
GGRGSSGGYQ--------------------SSSS------EGRLGGAGSIS---MSHSGM
GSSSG--NV-QTSGGSGYKS----GGGGSTSIRFS----QTT------------------
------------------------------------------------------------
----------SSS-QHNSTK----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------MSIHFSSRTTAFPGR----GAQM-RLSSG----RAGG-----
----------------------------------------------FSS---SSLYGLG-
------------TS-RPRVAV--RS-----------------------------------
---------------AYG------------------------------------------
----------------S-------P-----VGAGI------REITINQSLLAPL----RV
DIDPTIQQ--VRQ EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWALLQEQKST-----KGNRL--PRIFE-TQIAGLRQQLEALQL
DGGRLEVELRS-VQDVVEDFKNK-YEEEINRRTA---AENEFVLLK--K---DVDAAYMN
KVELEAKVDSLNDEISFLKTLNET-----ELAELQSQISDT----SVVLSMDNSRSLDLD
GIIA-DVKAQYEEMAS-HSRAEAEAWYQTK--FETLQAQAGKHGDDLRNTRNEIAEMN--
RNIQRLQAE-I--DNMKN------------------------------------------
-----Q-RA--KLEASIAEAEE-RGELAL-KDAHAKQ----EELEVALQQAKQDMARQLR
ECQELMNVKLALDIEIATYRKLLEGEE--------------------------S-RLS-G
DGMGP---V--------NISV---------------------------------------
----VNS----------TGS----------------SGSRLIFGG-----TMGSNALSFS
SS-----GGPAG------------------------------------------------
--------LKAYSIRTTSTTHRGPHN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MIARQQCVR-----G-GPRGFSCGSAIVGSG----KRG--AFSSVS---VSGGA----
-----------------------------------------GRCS-SGGFGSRSLYNLGG
N-KSISMSVAGSRQ-GA-CFGGAGG-----------FGT---------------------
---------------------------------------GGFG-----------------
---GGFGG----SFS--GKGGPGFP-VC--PAGGI------QEVTINQSLLTPL----HV
EIDPEIQK--VRTEEREQIKLLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWKLLQQQTTST----SSKNL--EPLFE-TYLSVLRKQLDTLVN
DKGRLQSELKT-MQDSVEDFKTK-YEEEINKRTA---AENDFVVLK--K---DVDAAYMN
KVELEAKVDSLNDEINFLKVLYDA-----ELSQMQTHVSDM----SVVLSMDNNRNLDLD
SIIA-EVRAQYEEIAQ-RSKAEAEALYQTK--VQQLQISVDQHGDNLKNTKSEIAELN--
RMIQRLRAE-I--ENIKK------------------------------------------
-----Q-CQ--TLQASVADAEQ-RGENAL-KDAHSKR----IELETALQQAKEELARMLR
EYQELMSVKLALDIEIATYRKLLEGEE--------------------------C-RMS-G
ECQSA---V--------SISVVGGSTSTGG------------------------------
---------------ISG-G---LGS-----------------------------GS---
---GFGL------------------------SSGFGSG--SGSGFGF--G-GS-------
----VSGSSSSKIISTTTLNKRR-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRISYR---SSTGGGMRGFSSGSAIVGGSG--GGTRS-SFSSVS-VSRVGGGRA--
-------------------------------------GG-GGGFGAGGGFGSRSLYNLGG
S-KRISLG----GL-RSG-AGVGYG-----------F--GGGAG--------FGLG----
-------YG--GG-AGAALGLGGAG-GGGGY---------------G--L----G-GFGM
GGP---------GFG--GRGGPGFP-VC--PPGGI------HEVTVNQSLLAPL----KL
DIDPEIQK--VRT QEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWSLLQEQGHTV----TRKSL--EPLFE-TYINNLRRQLDSLMG
ERGRLDSELRS-MQDMVEDFKNK-YEDEINRRTG---AENEFVVLK--K---DVDGAYMN
KVELQAKADGLADEINFLRALYEA-----ELSQMQQQVSDT----SVVLSMDNNRSLDLN
SIIA-EVKAQYEDIAN-RSRAEAEAWYQNK--YEELQVSAGRHGDDLRNTKMEISEIN--
RMVQRLRNE-I--ESVKK------------------------------------------
-----Q-CA--NLQAAIAEAEE-RGEMAL-KDAKSKL----AELEDALQKAKADLARQLR
EYQELMNVKLALDIEIATYRKLLEGEE--------------------------S-RLA-G
EGVG-A--V--------SVSVVSSSSGMGY------------------------------
------------GGGMGGGLSTGGGL----CM-GGGLSMGSGL------G----------
------------------------------------------------------------
----MG---GG--------------GGSY-TMSS------SVGGGGFGGGSGSYSYGGGS
NFSSS--SS-R-----GV--SS----STGGSVRIV----SKT------------------
------------------------------------------------------------
----------TTS-KKTIR-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------VR------------------
----FLKHQNK-VLETKWKLLQQQKTTT----SSKNL--EPFFE-TYISALRKQLDSLAN
DKGRLQSELKI-MQDSVEDFKAK-YEDEINKRTA---AENDFVVLK--K---DVDAAYMS
KVELDAKVDALNDEINFLRVLYAA-----ELSQMQTHVSDT----CVVLSMDNNRNLDLD
SIIA-EVRAQYEEIAQ-RSKGEVEALYQTK--VQQLQTSVDQYGDNLKNTKSEIAELN--
RMIQRLRAE-I--ENIKK------------------------------------------
-----Q-CQ--TLQASVADAEQ-RGEVAL-KDAYSKR----TELETALQKAKEELARMLR
EYQELMSVKLALDIEIATYRKLLEGEE--------------------------C-RMS-G
ECQSA---V--------SISVVGGAAGAGG------------------------------
---------------IG-GG---LGS----G---SGFG--LGS-----------------
---------------------------------GFGSG--SGIGFGF--G-GG-------
----VCGSSSGKIISTSTLSKRS--YR---------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
-TM-SRQPSVT--FQPG-GRRSFSTASASTPA-----VGRS-RFSSLS-VARSTG--GSA
GPGRLS--------------------------SA------------GAAFGSRSLYNVGG
T-RRLSTGGC-GGG-----FRSG-------------FGG--RA----SGGFGA-----G-
--------------SGFGYG--GAAGGGY-------------------------------
--------------GAWGFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPAIQR--VRKEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWELLQEQGSK----TVRQNL--EPFFD-TYINDLRRQLDSVTT
ERGRLDAELRN-MQDVVEDFKVR-YEDEINKRTA---AENEFVALK--K---DVDSAYMN
KVELEAKVNSLTDEINFLRMLFEA-----ELSQMQTQVSDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEDIAN-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEISEMN--
RVIQRLRAE-I--DSIKK------------------------------------------
-----Q-CS--SLQTAIADAEQ-RGELAL-KDARAKL----VDLEEALQKAKQDMARLLR
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VS-PVNIS--------VVTSTV----------------------------------
------------SSGYSGGS--AMG-----------------------------------
---------------------------------------GGSLGLGGGSG----YSFAT-
-----------------------SA-------GHNLG--A--GLGG-------------S
GFSAS---SSRGLGG------------GGSSVKFV----STTS-----------------
------------------------------------------------------------
------------SSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTQKSYQ--MS--TSGPQAFSSCFYMSGPG-----ACI-SSSSL-------------
-------------------------------------------------------SRVGS
-----------------------S--------------TG------------LGG-----
---------------GYG------------------------------------------
-----------------GASG----------IGGI------TAVTFNQSLLSPV----NL
EVDLNIQ-------EKEQIKILN--------------N--KF----------------------FPEQQNK-MLGNKWSFLQQ-QKT-----AGINM--DNMFE-SYINNLRRHLETLSQEKLKLEAELGN-MQGLVEDFKNK-YEDEINKRTE---MENEFVLIK--K---DVTEAYTNKVELESRLEG---------QLFEE-----EIQELQSQISDT----SVVLSMDNSHSLDMDSIIA-EVKAQYEETAH-HSQAEAESTYQIK--YVELQTLAGKHGDDQRCTKTDISEMN--WNISWLQAE-I--EGLKG-----------------------------------------------Q-RA--SLEVAIADAQQ-RGELAI-KDGNAKL----SELEAALQWAKQDMAWQLREYQELMNVKLALDIKIATYRKLLEGEES---------------------------RLE-S---GM---Q--------NMSIHMKTTSS-----------------------------------------------YAS---------------------GLSL--------------------AYG------------------------------GLTSPGLSYGLG--------SS----------------------------------S---------GSGSVT---------GSSSFNCT-----------SST-----SSTRAMVVKEI------ETRDGKLMSESSDVLPK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EKEQIKILN--------------N--KF------------------
----FPEQQNK-MLGNKWSFLQQ-QKT-----AGINM--DNMFE-SYINNLRRHLETLSQ
EKLKLEAELGN-MQGLVEDFKNK-YEDEINKRTE---MENEFVLIK--K---DVTEAYTN
KVELESRLEG---------QLFEE-----EIQELQSQISDT----SVVLSMDNSHSLDMD
SIIA-EVKAQYEETAH-HSQAEAESTYQIK--YVELQTLAGKHGDDQRCTKTDISEMN--
WNISWLQAE-I--EGLKG------------------------------------------
-----Q-RA--SLEVAIADAQQ-RGELAI-KDGNAKL----SELEAALQWAKQDMAWQLR
EYQELMNVKLALDIKIATYRKLLEGEES---------------------------RLE-S
---GM---Q--------NMSIHMKTTSS--------------------------------
---------------YAS---------------------GLSL-----------------
---AYG------------------------------GLTSPGLSYGLG--------SS--
--------------------------------S---------GSGSVT---------GSS
SFNCT-----------SST-----SSTRAMVVKEI------ETRDGKLMSESSDVLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--------MSS--KS-TTIRRGFSTSSARVPA-----GSRS-GFSSVP-VSRSRGGVGLG
G-------------------------------AC-----------GGAGFGSRSLYGLGS
S-KTISTGGG----SC--VLGSG-------------YGS--RV----GGGFGFGGGA-G-
--------------SGFGLG--GG--A------GS-----------------SF----GL
G--DG-AGFGG-GYGGSGFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPTIQR--VKTEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVRQNL--EPLFE-EYISNLRRQLDNILE
ERGRLDSDLRG-TQDLVEEYKSK-YEDEINRRTA---AENEFVTLK--K---DVDAAYMN
KVELQAKTDGLREEVDFLTVLYNA-----ELSQMQTHISDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEAIAQ-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEISEIN--
RMIQRLRSE-I--DHVKK------------------------------------------
-----Q-CA--NLQAAIADAEQ-RGELAL-KDAKNKL----ADLEDALQKAKQDMARLLK
EYQELMNVKLALDMEIATYRKLLEGEE--------------------------C-RLN-G
EG--VG-PV-------N-ISVTQSTI----------------------------------
------------SSGCNSAGG-------------------------V-------------
---------------------------------------GGGLGLGAGSG----YS----
-----------------------YGGG--------------LSLG--------------G
GFSSG---SGRGIA--GGLS--STGGG-SPTIKYT----NTSS-----------------
------------------------------------------------------------
------------TSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------SRFGG-
--------------------------A--------------AYCSPRGSFGSHSHHNLGS
N-TRISVCMAQGASHG-RPF----------------------------------------
--------------GGFGVG------------------TGNFL-----------------
-------GLC-------NSRPNFGA-SC--PPGGI------QEVTVNQSLLTPL----NV
EIDPEIQR--VRTQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWDLLQKQSQNNM--TA-MDL--GPFFK-QYIGNLQRHLNGLQN
ERKKLDHELSD-AQDKMEKLKIS-YEKEINKRTA---AENEFITLK--K---DADALHIL
HANLEGVCESLSEEYTFLKILYEM-----ELCQVQTLVSDT----NVVLSMDDNRCLDLK
SIIA-EVKTQYEEIAK-RSRAEAESWYQTK--YEELKVTAGKHEEYLRETKKEIAELT--
HAVRRLKGE-I--DSMKK------------------------------------------
-----Q-CK--RLQTAIADAEQ-RGELAI-KDAKKKL----GDLKTALHHTKEELTKLLR
DYHELMNVKLALDMEITTYKKLLECEE--------------------------S-RMS-G
ECSSA---V--------SISVTGCSTNMHG------------------------------
-----------------GSSRGV---------GSGSSGDG--VS----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQSSVS--FR-SGGSRSFSAASAITPS-----VSRT-SFSSV---SRSGGG--GG
GGSRVS--------------------------LG-------GA-YGAGGYGSRSLYNVGG
S-KRISFSSG----GG--SFRNR-------------FGAG--A----GGSFGFGGGA-G-
--------------SGFGFG--GGAG-S------------------------GF----GF
G--GGAGFG-G-GYGGAGFP------VC--PPGGI------QEVTVNQNLLTPL----NL
QIDPTIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVRQNL--DPLFE-QYINNLRRQLDGVLG
ERGRLDSELRN-MQDLVEDFKNK-YEDEINKRTT---AENEFVMLK--K---DVDAAYMN
KVELEAKVDALMDEINFMKMFFDA-----ELSQMQTHVSDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEDIAN-RSRTEAESWYQTK--YEELQQTAGRHGDDLRNTKHEISEMN--
RMIQRLRSE-I--DNVKK------------------------------------------
-----Q-CA--NLQNAIADAEQ-RGELAL-KDARNKL----TELEEALQKAKQDMARLLR
EYQELMNTKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VG-PV-------N-ISVVTNSV----------------------------------
------------SSGYGGGS-LGFGG----G---SG------FGGGSGV-----------
------------------------------------------------------------
----------------------------------GLG--GGLSVGS-------------S
GFSAS---SGRGV--GFGS----GGG-SSSSVKFV----STTS-S---------------
------------------------------------------------------------
-------------SRRSFKS----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--TMSCKSTVK--TK-TISCRGFSAGSARVPG-----VCRS-GFSSVS-LSRSRGSGGLA
G-------------------------------VC-----------GGAGFGSRSLYGLGG
S-KRISIAGG----SC--VIGGG-------------YGG--RI----GVGYGFGGGA-G-
--------------SGIGFG--AG--A------GS-----------------GF----GL
G--GG-AGFGG-GYGGYGFS------VF--PTGGI------QEVTVNQSLLTPL----NL
QIDPTIQR--VRTEEREQIKTLNNKFASF------REC--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTR----TVRQNL--EPLFE-QYINNLRRQLDSILG
ERGRLDSELRG-MQDTVEDFKNK-YEDEINKRTA---AENEFVKLK--K---DVDSAYMN
KVELQAKVDALTDEINFLRTFYDA-----ELAQMQSYISDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEEIAQ-RSRAEAESWYQSK--YEELRVTAGRHGDDLRNTKQEISEIN--
RVIQRLRSE-I--DHVKK------------------------------------------
-----Q-CT--SLQSAIADAEQ-RGELAL-KDARNKL----ADLEDALQKAKQDMARLLK
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--AG-QV-------N-ISVVQSTV----------------------------------
------------SSGYG-----------------------G--ASGL-------------
---------------------------------------GSGLGIGGGSG----CS----
-----------------------YS----------IG--G--------------------
GFSSG---SGRAIG--GGYG--SSGGS-CSTIKYT----TTS--S---------------
------------------------------------------------------------
------------SSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------M--
----ASQVCKK--TI-SGRSLGFSGRSAVV----------W-M-SC---VARSAAV-G--
-----GG-------------------------ASGFR----GG---AGGFGSRSLYNLGG
H-KSISMSVAAGGS-RAGGFGGGRS------ICGSGFGG---------------------
---------------------------------A-----GALGG------AGGFGGAGAF
GGAGGFGGPG--GFGG---P------GG--FPGGI------QEVTINQSLLQPL----NV
EIDPQIGQ--VRAQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWELLQRQSPGSG--AEPANL--KPLFE-SYISFLRKQLDSLVG
EKGGLDSELRS-VQGLVEDFKKK-YEEEINKRTT---AENDFVGLK--K---DVDAAYTS
KVELQAKADGLTDEINFLRALFEM-----ELSQMQSHVSDT----SVVLSMDNNRSLDLD
SIIA-EVRAQYEDIAQ-RSRAEAEAWYQTK--LGELQTTAGRHGDDLRSTKSEIAELS--
RVIQRLRAE-I--ESVKK------------------------------------------
-----Q-NA--SLQTAIAEAEQ-RGELAL-KDANAKL----QELQAALQQAKEELARLLR
DYQELMNVKLALDVEIATYCKLLEGEE--------------------------S-RMS-G
ECRDA---V--------SIWVVQKLARSSGSQGNQ--RTASSVASGHGCTPRLGASCQP-
-------------LGWGCHT----------------------------------------
---------------------------------------------DGGGG--SGLPGL--
SL--KSSLWSPAAVVNNVT------SRGYP-----------------SGP--SFESQSGM
GSGSG--SL-QRSGSSGYEL----GSEDSTRVRFS----ETS------------------
------------------------------------------------------------
----------RSR-QQCSK-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------SPAPETTVR--------V-------EKSERGGR
ERIGQPQTRGR--WKQG-ER----PGAAGASAP----AGRS-RFSSVS-VARCTG--GGA
GPGRIS--------------------------ST------------GAG-----------
---------GRGGS-----FRSG-------------FGG--RA----SSGFGV-----S-
--------------SGLGYG--GAA-----------------------------------
--------------GGGGFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPAIQR--VRQEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWELLQEQGSK----TVRQNL--EPFFD-AYITDLRRQLDGVTT
ERGRLDAELRN-MQDVVEDFKVR-YEDEINKRTA---AENEFVALK--K---DVDAAYMN
KVELEAKVNSLTDEINFFRMFFEA-----ELSQMQTQVSDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEDIAN-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEISEMN--
RVIQRLRAE-I--DSVKK------------------------------------------
-----Q-CS--SLQTAIADAEQ-RGELAL-KDARAKL----ADLEEALQKAKQDMARLLR
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VS-PVNIS--------VVTSTI----------------------------------
------------SSGYGGGS--TVG-----------------------------------
---------------------------------------GGSLGLGGGSS----FSFAS-
-----------------------ST-------GHNLG--A--GPGG-------------S
SFSAS---SSRGLGG------------SGSSVKFV----STTS-----------------
------------------------------------------------------------
------------SSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------GYGSRRS------IC----------------GGGFGGGFGGG
--R--GVGGGFG-------------------------------GAGGFGGAGGF------
GGLGGFGGAG--GFGG---PGGFGP-GG--FPGGI------QEVTVNQSLLQPL----NV
EIDPQIGA--VKTQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQQQGVNSV--TGTNNL--EPLFE-SYISNLRRTLDVLQG
ERGKLDGELRN-MQELLEDFKKK-YEDEINKRTT---AENEFVGIK--K---DVDAGYMN
KVELQARTDSLTDELNFLRVLYEM-----ELSQMQSHVSDT----SVILSMDNNRCLDLD
SIIA-EVKAQYEEIAQ-RSKAEAEAAYHIK--LGELQTTAGRYGDDLKTTKSMVMELN--
RMIQRLRTE-I--ENVKK------------------------------------------
-----Q-NA--KLQAAIAEAEQ-RGELAL-KDAQAKL----QGLQSALQKAKDDLARLLR
DYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RMS-G
ECQSA---V--------SISVVSNVTSS--------------------------------
-------NTSGSLGGSRGSFGGGSGS----FG--G-----TSSSG---------Y-----
--------------LSSGGSVSGSRGGVSG---------SR-----GSSG-SN---LG--
GLRPGSGGYS--------------------SGSS---------------------SGSGG
YSSGS--SL-QTSGSGGYSS----GSRGSSSVHVS----QTS------------------
------------------------------------------------------------
----------SSQ-RNF-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MIARQQGIR-----G-GSRGFSSGSAI-VGG----GKKV-AFSSAS---MSGGA----
-----------------------------------------GRCS-SGGFGSRSLYNFRG
N-KNISCSAAGSRQ-GA-GFGSAGG-----------FG----------------------
-------------AGSFG----------------AGFGVGSFG-----------------
---GGFGG----SFS--GRGGPGFP-VC--PAGGI------QEVTINQSLLTPL----HV
EIDPEIQK--VRT EEREQIKVLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWKLLQQQTTTT----SSRNL--DPFFE-TYISALRKQLDALAN
EKGRLQSELKM-MQDSVEDFKTK-YEDEINKRTA---AENDFVVLK--K---DVDAAYMT
KVELQARVDSLNDEINFLRVLYEA-----ELSQMQSHVSDT----SVILSMDNNRDLDLD
SIIA-EVRAQYEEIAQ-RSKAEVEAWYQTK--VQQLQTSVDQHGDNLKSTKNEISELN--
RMIQRLRAE-I--ENVKK------------------------------------------
-----Q-CQ--TLQTSVADAEQ-RGELAL-KDAYSKR----TELEVALQKAKEELARMLR
EYQELMSVKLALDIEIATYRKLLEGEE--------------------------W-KAG-G
KLRDRDPGP--------WVWVSSGLVSTG-------------------------------
-----------------------------------------------------GIGG---
---GFGL------------------------GSGFGSG--SGSGFGF--S-GG-------
----VSGSSGSKIISTTT-LT-RRSQL---------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

MTPVGVF---------SDTLSGCKKDGPVPKAKPRDFSDFSLDAPATKPCRS--------
------------------------STYKRPRFRVSAFTHLVPR----AS--GLTAPSLLS
PTMIARQQCVR-----G-GSRGFSGASAIVGGG----KRA--AFSSVS---VAGGA----
-----------------------------------------GRCSSSGGFGSRSLYNLGG
N-KSISMSVAGSRQ-GA-GFGGAGG-----------FGA---------------------
---------------------------------------GGFG-----------------
---GGFGS----SFG--GRGGSGFP-VC--PAGGI------QEVTINQSLLTPL----NV
EIDPEIQK--VRTEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQQQTTTT----SPKNL--EPFFE-TYLSALRKQLDTLGN
DKGRLQSELKA-MQDSVEDFKTK-YEEEINKRTT---AENDFVVLK--K---DVDAAYMT
KVELEAKVDALNDEINFLRVLYEA-----ELSQMQTHVSDT----SVVLSMDNNRNLDLD
SIIA-EVRAQYEDIAQ-KSKAEAEALYQTK--VQQLQTSVDQYGDNLKSTKSEIAELN--
RMIQRLRAE-I--ENVKK------------------------------------------
-----Q-CQ--TLQASVADAEQ-RGELAL-TDAYNKR----TELETALQKAKEELARMLR
EYQELMSVKLALDIEIATYRKLLEGEE--------------------------C-RMS-G
EYQNT---V--------SISVVGGGASSGA------------------------------
---------------IGG-G---FGL-----------------------------GS---
---GFGS------------------------GFGFG--------VGG--G-GG-------
----IGGGSSSKIISTTTLTKRSQR-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSSKTTVR--SQS-TSRRGFSASSARVPG-----LSRS-GFSSVS-VCRSRGSGGTG
A-------------------------------MY-----------GGAGFGSRSLYNLGG
S-KRISIGGG----SC--AIGGG-------------YGS--RV----GGGFGFGGGI-G-
--------------NGFGYG--GG--A---------------------------------
------AGFGG-GYGGAGFP------VC--PPGGI------QEVTINQSLLTPL----NL
EIDPTIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWSLLQEQGTR----TVRHSL--EPLFE-QYINNLRRQLDSIVS
ERGRLDSELRN-MQDAVEDYKNK-YEDEINKRTT---AENEFVTLK--K---DVDAAYMN
KTELQAKADGLVDEINFLRALYEA-----ELSQMQTHVSDT----SVILSMDNNRSLDLD
SIIA-EVRAQYEEIAQ-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEIAEIN--
RMIQRLRSE-I--DHVKK------------------------------------------
-----Q-CA--NLQAAIADAEQ-RGELAI-KDARSKL----EGLEDALQKAKQDMARLLK
EYQELMNVKLALDIEIATYRKLLEGEE--------------------------C-RLN-G
EG--VG-QV-------N-ISVVQSTV----------------------------------
------------SSGYGSAA------------------------SGM-------------
---------------------------------------GSGVGLGGG-S----GYTY--
------------------------SSG--------------HSLG--------------G
GFSSG---SGRGISVGGGLS--SVGG-STSSIKYT----TS-S-----------------
------------------------------------------------------------
------------SSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
-----------------------------------C--------TRL---PQELPQPASL
PTM-SRQSTIT--FQTG-SRRGFSAASATTPA-----AGRS-RFSAVS-VTRSAG--GNT
GLGRIS--------------------------GS------------GSGFGSRSLYNLGG
S-KRVSVGAC-GSG-----FRSG-------------FGS--RA----SGGFGV-----T-
--------------NGFGYG--SGIGGGY-------------------------------
--------------GGAGFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPSIQR--VRKEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQEQGSR----VVRHSL--EPLFE-AYINDLRRQLDGVTA
ERGRLDSELRS-MQEVVEDFKVR-YEDEINKRTA---AENEFVALK--K---DVDGAYMS
KVELEAKVNTLTDELNFLRMVYEA-----ELSQMQNQVSDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEDIAN-RSRAEAEAWYQTK--YEELQVTAGRHGDDLRNTKQEISEMN--
RMIQRLRSE-I--DNVKK------------------------------------------
-----Q-CS--SLQTAIADAEQ-RGELAL-KDARAKL----EGLEEALQKAKQDMARLLR
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VS-PVNIS--------VVTSTV----------------------------------
------------SSGYGGGS--SLG-----------------------------------
---------------------------------------GGSLGLSGGSG----YSFTS-
-----------------------SG-------GHSLG--A--GLGG-------------S
SFSAG---SSRGLGG------------SGSSVKFV----STTS-----------------
------------------------------------------------------------
------------SSRKSYRH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MNRQACKA--P--GGRSQGFSGHSAAVSGG------SR-M-SC---VARTGGS-G--
-----GG-------------------------ACGFQ----SG---AGSFGSCSLYNLGG
R-KSISISVAAGGS-QAGGFGGGHS------SCGSGFRGSFGSSFGGSRG----------
------MGS-------------------------------------------GFGGAGGF
GVAGGLGGLV--GFGG---PGGFGP-GC--FLGGI------QEVTVNQSLLHPL----HM
EIDPQIGQ--VKA QEREQIKSLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWELLQQQTVGSG--SIPYSL--EPLFE-SHISSLCKRLDSLLG
ERGSLEGELKN-MQDLVEDFKKK-YEDEVNKCTV---AENEFVGLK--K---DMDATYMS
KVELQAKVESLTDEVNFPRTLYDM-----ELSQMQSHVRDM----SVVLSMDNNRDLDLD
SIIA-EVRTQYEEIAQ-RSKAEAEMLYQTK--LGELQTTAGRHGDDLRSTKREIQELN--
RVIQRLRAE-I--ENVKK------------------------------------------
-----Q-NA--NLQAAITEAEQ-RGEMAL-KDANAKL----QDLQAALQKAKDDLARLLC
DYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RRS-R
GAF---------------------------------------------------------
--------------------KGVSGS----SS--SSSGSRGSSSS---------------
----------------SSGSSY------------------------RAGS--SGSGSG--
GR---------G------------NNRGYQSASS------GSRLGSGGSS--SV-SQSGI
GFSSG--GT-QNSVGSGYKP----GNGGNIGVHFS----QTT------------------
------------------------------------------------------------
----------SSS-QQCSK-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
H-------------F---SSRLLSSRSAGFSGH----CAQA-RLSS--------------
--------------------------------------------------------GLG-
------------AS-WPRVAM--RS-----------------------------------
---------------AYG------------------------------------------
----------------G-------P-----LGAGI------REVTINQNLLAPL----RL
DADPCLQR--VLQ EEREQIKTLNNKFASF------IDK--VR------------------
-------QQNK-LLETKWALLQEQKSA-----KSSRL--PDIFE-AQIASLRGQLEELQV
DGGRLEAELRS-MQDVVEDFKNK-YEDEINRRTA---AENEFVVPK--K---DVDAAYVS
KVELEAKVVAL-------------------MTELQSQIADT----SVVLSMDNSRSLDLD
GVIA-EVKAQYEEMVK-CSRAEAE----TK--FEILQVQTGKHGDDLRNTRNEIAEMN--
RAIQRLQAE-I--DAIKN------------------------------------------
-----Q-RT--KLEAAIAEAEE-RGELAL-KDARAKQ----EELEAALQRTKQDMAWQLR
EYQELMSVKLALDLEIATYHKLLEGEE--------------------------S-RLA-G
DGVGA---V--------NISV---------------------------------------
----VNST-GGSGN---GSG----------------GAIGLSFGG-----TMGSNALSFS
SS-----VGPGP------------------------------------------------
--------LKAYSIWTTSTSRKSSYN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTQKSYK--VST--SAPRSFSSRSYTSGPG-----SRI-SSSAF-------------
-------------------------------------------------------SRVGS
G----------------------S-----------SFRGG------------LGTSM---
--------------SM---A----------------------------------------
---------------GSY-GGAP-------GLGGI------TAVTVNQSLLSPL----KL
EVDPNIQA--VRT QEKEQIKTLNNKFASF------IDK--VR------------------
----HLEQQNK-VLETKWNLLQQ-QKT-----ARSNI--DNMFE-SYINSLRRQLETLAQ
DKLKLEVELGN-MQGLVEDFKTK-YEDEIQKRTD---MENEFVIIK--K---DVDEAYMN
KVELESRLEGLTDEINFYRQLYEE-----EIREMQSQISDT----SVVLSMDNNRNLDLD
GIIA-EVKAQYEEIAN-RSRAEAETMYQIK--YEELQILAGKHGDDLRRTKTEISEMN--
RNISRLQAE-I--EGLKG------------------------------------------
-----Q-RA--SLEAAIADAEQ-RGEMAV-KDAQAKL----AELEAALRNAKQDMARQLR
EYQELMNVKLALDVEIATYRKLLEGEES---------------------------RLE-S
---GM---Q--------NMSIHTKTTSG--------------------------------
---------------YAG---------------------GLTS-----------------
---AYG---------------------------------TPGFNYSLSLA----------
---------------------------------------------SGG---------GPG
SFSRT--------------------SSKAVVVKKI------ETRDGKLVSESSDVLSK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------MAMHFSSRSAVPPGR----VSFT-RVSSV----GST------
--------------------------------------------RSTGGFGSSSLYNLG-
------------AG-GGRKVSSAGR-----------------------------------
---------------YYG------------------------------------------
----------------V-AGSAGFG-----PGAGI------QEVSINPSLLAPL----NL
EIDPQHQK--VRKEEREQIKVLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQEQKSG-----KSSNI--PTLFE-SYINSLRHQLDGLLS
DQGRLEGELKS-MQDLVEDFKNK-YEDEINKRTS---AENEFVVIK--K---DVDNAYMN
KVELEAQVDSLTDEIKFLRSLYEL-----ELNELQAQISDT----SVVLSMDNNRSLDLD
GIIA-DVKAQYEEIAQ-RSRAEAETMYQIK--FETLQAKAGKHGEDLRNTKTEISEMT--
RNIQRLQSE-I--DNIKG------------------------------------------
-----Q-RA--KLEAAIAEAEE-RGELAL-KDARAKQ----DELEAALQKAKQDMARQLR
EYQELLSIKLALDIEIATYRKLLEGEE--------------------------S-RCR-G
TREGE---G---------------------------------------------------
-GAMVNNS-R------SYRS----------------QGQNLGFGG-----TMGLNALNFG
VRPSTSPGATGV------------------------------------------------
--------NQTYSYQFTTSSQKSDRN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
----MQNLVT--QK--SSGPWAFSSCTYMSGPG-----VCI-SSLSC-------------
-------------------------------------------------------SRVGS
-----------------------S-----------SFRGG------------LGG-----
---------------GYG------------------------------------------
-----------------GASG----------MGGI------IAIMVNQSLLSPL----NL
EVDPNIQ A--MCT QKKEQIKTLN-KFASF------IDK--VW------------------
----FLEQQNK-VLETKWSLLQQ-QKM-----ARSNM--DNMLE-SYINNLRRQLETLGQ
EKLKLEAELGN-MQGLGEDFKNK-YEDEINKHTE---MENEFVLIK--K---DVDEAYTN
QVELESLLEGLTEEINFLRQLYEE-----EIRELQSQISDM----SVVLSIDYSCSLDMD
SIIP-EVKVQYEEIAN-CSRAEAESMYQIK--YEGLQTLAGRNWDDLRRTKTEISEMN--
RNISWLQAE-T--EGLKG------------------------------------------
-----Q-RA--SLEAAITDAEQ-RGELAV-KDANAKP----SELEAALQRAKQDMMGQLR
EYWELMNVGLTLDIEIATYRKLLEGEES---------------------------RLE-S
---GM---Q--------NLSIHTKTTSS--------------------------------
---------------YAG---------------------GLSS-----------------
---AYG------------------------------GLTSPGIIYRLG------------
---------------------------------S--------SFGSGA---------GSS
SFSRT-------------------SSTRAVVVKKI------ETHDGKLESESSDVLSK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------VR------------------
----FLEQQNK-LLETKWALLQEQRSA-----KSSQL--PGLLE-AQIAALRRQLEVLQA
DGGRLELELKN-TQDVVEDFKKK-YEEEINCRTA---AENEFVVLK--I---DVDAAYMN
KVELEAKVDALNDEINFLKTIYET-----ELTELQAQISDT----SVVLSMDNSRYLDLD
SIIA-EVKAQYEEMAN-RSRAEAEASYQNK--LEVLQAQAGKHGDDLRNTRNEIADMN--
RAIQRLQAE-T--DNIKN------------------------------------------
-----Q-RA--KLEAAIAEAEE-NGELAL-KDARAKQ----EELEAALQRAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEE--------------------------S-RLA-G
DGVGP---V--------NIAV---------------------------------------
----VNSV-GG-------SS----------------AGGGLTFGG-----TMGSNALSFS
SG-----GRPGT------------------------------------------------
--------KRIFSHKTTHRSARN-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------M--
----NRQVCKT--S--GGGSLSFSGRSAVVSGSGGGGSSSR-M-SC---VARSVAA-G--
-----GG-------------------------ASGFR----GG---AGGFGSRSLYNLGG
H-KSISMSVAAGGS-RAGGFGGGRS------I--CG------SGFGGGLGGGLGGGLGSG
------FGGGFG--GGFG--------GAGA-----------------------FGGAGGF
GGAGGFGGPG--GFGG---P------GG--FPGGI------QEVTVNQSLLQPL----NV
EIDPQIGQ--VRAQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWELLQRQGPNSV--TGTNNL--EPLFE-NRINYLRSYLDSIVG
ERGRLDSELRS-MQDLVEDFKKK-YEDEINKRTA---AENEFVTLK--KARTDVDAAYMN
KVELQAKVDSLMDEINFLRTLYDA-----ELSQMQSHVSDM----SVVLSMDNNRSLDLD
SIIA-EVRAQYEDIAQ-RSRAEAEAWYQTK--LGELQTTAGRHGDDLRSTKNEIAEIN--
RMIQRLRNE-I--ENVKK------------------------------------------
-----Q-NA--SLQTAIAEAEQ-RGELAL-KDANAKL----QELQAALQQAKDDLARLLR
DYQELMNVKLALDVEIATYRKLLEGEE--------------------------S-RMS-G
ECQSA---V--------SISVVNSSS----------------------------------
-------TTSAAAGGYGGGYGG-------------GYGGGFGVG----------------
-----------------------------G---------GAGSGFGRGGG--SGFGGG--
SGLGGGSGFGGGS----------GLGGGS-------------GLGGGSIG--FSVGSSGF
GSGSG--GR-IGVSGGGFSSG---SSSRGSSVKFS----QSS------------------
------------------------------------------------------------
----------QRY-SR--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQCT----VRS-QGRTGFSAASAFIPS-----ACST-GFISRS-VAQGGSCST--
-------------------------------------AAGYGGFGG--GFGSRSLYSVGG
C-KRISMAGRGSG----F-Y--GP------------------------------------
--------------AGFGAG------TGISCGFGGA------------------------
---------F--GFGG-GMGGPGFP-AV--PTGGI------QEVSVNQSLLKPL----NL
AIDPSIQS--IRK EEKEQIQTLNNKFASF------IDK--VR------------------
----FLEQENK-VLETKWALLQEQGHKT----VRNNI--EPLFE-AYINNLRRQLSSLLA
DKENIGGELSK-VQSLAEDFKSK-YEEEINKRTA---AENEFVILK--K---EVDSTYMT
KTELQARLDALLEEIDFLRALYEA-----ELSQLQSQIADT----SVILTMDNNRSLDMD
SIIA-EVKAQYEDIAK-RSREEAESWYQSR--YEELQATAGRHGDDLRSTKQEISELN--
RHVQRLRAE-I--DSVKK------------------------------------------
-----Q-CA--SLQTAIADAEQ-RGELAL-KDARDKL----AELETALQQAKADLARQLR
EYQELMNVKLALDIEIATYRKLLEGEE--------------------------C-RLS-G
EGAG-A--V--------NISVTRTSV----------------------------------
----------------G-------------------------------------------
--SGYGSGS---------------------------------------------------
-------------------------CQGF-RGSS------GAGAGLCAG---------GM
GFSSG--SG-Q-GMAGSCV-VG----GSSSSMQYI----SSS------------------
------------------------------------------------------------
-----------ST-KRCY------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSR
QFS-SRSGYWS--G------GGFSSGSAGVGY-----SRRV-TSSSST-IRRSGGG----
-GGRFS------------------------GGSCRAG--------GGGGFGSRSLVNLGG
S-KSLCQSVAGGSY-GRGGFGGGG-------YGGGGFGGGSYGG------RSFGG-----
--------------GGFG----GG----GGFG-GGGFGGGGFGGGGLG-------GGFGN
-------------IGGGFGGGNFGP-AY--PPGGI------QEVTINQGLLQPL----NV
EIDPEIQK--VKTREREQIKDLNNKFATF------IDK--VR------------------
----FLEQQNQ-VLQTKWELLQQVDTST----RTQSL--EPLFE-AYVSDLRQKLDTLKS
DRSRMESELKN-MQDTVEDFKRK-YEDEINKRTD---AENEFVTIK--K---DVDNAYMN
KVDLENKVDWW--DINFFKVLYDT-----ELSQMQTHISDT----NVILSMDNNRSLDLS
SIIS-EIQGHYEQVAQ-KSKAEAEAMYQTR--YEELQITAGRHGDQLRNTKSEISEMN--
RMIQRLKSE-I--ESVKK------------------------------------------
-----Q-IS--RLQQAIADAEQ-RGENAL-KDAREKL----ADLEDALQKAKEDMTRLMR
DYQELYNVKLTLDAEIATYRKLLEGEE--------------------------S-RVS-G
ECVP-S--V--------SVSVSTSHVCVGG------------------------------
------------GGGRFGGG--------------GSYGSGGGGG-----GGGGGYGS---
---SSGGG---RHGSRGGG---GSYGSGG-------GGYGSSGGRGSSSG-GGSYGSSGG
W------------------------------------------GSSSGGGA-------GG
GGGGG--S----SSGG--GSSSVKGSSGSSSVKFT----STS------------------
------------------------------------------------------------
----------HST-VTN-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MISRQQCVR-----G-GSQGFSCGSAV-VGG----GKRV-AFSSAS---MSGGA----
-----------------------------------------GRCS-SGGFGSRSLYNLGG
N-KSISMSMAGCRQ-SG-SFGAGGG-----------FG----------------------
-------------AGGFG----------------AGFGAGSFG-----------------
---GGFGG----SFG--GRGGPGFP-VC--PAGGI------QEVTINQSLLTPL----HV
EIDPEIQK--VRTEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQQQTTTT----STKNL--EPFFE-AYLSALRKQLDSLVN
DKGRLQSELKT-MQDSVEDFKTK-YEEEINKRTA---AENDFVVLK--K---DVDAAYMN
KVELEAKVDALNDDSRFLV--SDK-----ELSQMQSHVSDT----SVVLSMDNNRCLDLD
SIIA-EVKAQYEEIAQ-KSKAEAEALYQSK--FQQLQTSVDQYGDNLKNTKSEIAELN--
RMIQRLRSE-I--ENVKK------------------------------------------
-----Q-CQ--TLQASVADAEQ-RGDLAL-KDAYSKR----AELEAALKKAKEELTRMLR
EYQELMSVKLALDIEIATYRKLLEGEE--------------------------C-RMS-G
ECQNA---V--------SISVVGGAASAGG------------------------------
---------------IG-GG---LGS----C---SGFG--LGG-----------------
---------------------------------GFGSG--SGSGYGF--G-A--------
--------SSSKIISSTTL-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MIARQQCVR-----G-GPRGFSCGSAIVGGG----KRG--AFSSVS---MSGGA----
-----------------------------------------GRCS-SGGFGSRSLYNLRG
N-KSISMSVAGSRQ-GA-CFGGAGG-----------FGT---------------------
---------------------------------------GGFG-----------------
---GGFGG----SFS--GKGGPGFP-VC--PAGGI------QEVTINQSLLTPL----HV
EIDPEIQK--VRTEEREQIKLLNNKFASF------IDK--VQ------------------
----FLEQQNK-VLETKWNLLQQQTTTT----SSKNL--EPLFE-TYLSVLRKQLDTLGN
DKGRLQSELKT-MQDSVEDFKTK-YEEEINKRTA---AENDFVVLK--K---DVDAAYLN
KVELEAKVDSLNDEINFLKVLYDA-----ELSQMQTHVSDT----SVVLSMDNNRNLDLD
SIIA-EVRAQYEEIAQ-RSKAEAEALYQTK--VQQLQISVDQHGDNLKNTKSEIAELN--
RMIQRLRAE-I--ENIKK------------------------------------------
-----Q-CQ--TLQVSVADAEQ-RGENAL-KDAHSKR----VELEAALQQAKEELARMLR
EYQELMSVKLALDIEIATYRKLLEGEE--------------------------Y-RMS-G
ECQSA---V--------SISVVSGSTSTGG------------------------------
---------------ISG-G---LGS-----------------------------GS---
---GFGL------------------------SSGFGSG--SGSGFGF--G-GS-------
----VSGSSSSKIISTTTLNKRR-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
----------------------------------------------------------MR
-SSMARRTYTT--------KGGFSSNSASGG---GGPRAHT-SFSSVT-MSRSSGSGGG-
--------------------------A--------------RCGTSTGGFGSRSLYNLGG
S-KSISLSMAGGASSG-RAL----------------------------------------
--------------GSFGHG------------------SGAFM-----------------
-------GMG-------AGRQTFGP-VC--PPGGI------QEVTVNQSLLTPL----HV
EIDPEIPQQQVRLLHRQEIYTYIVIYINW------VQK--VR------------------
----FLEQQNK-VLETKWALLQEQGQNLG--VTRNNL--EPLFE-AYLGSLRRQLDNLQG
ERGRLDLEFRN-VQDLVEDFKNK-YEDEINKRTA---AENEFVVLK--K---DVDAAYMG
RMDLHSKVGTLTEELDFLNHLYEM-----ELSQVQTNVSDT----NVILSMDNNRKLDLD
SIIA-EVKAQYELIAQ-RSRAEAEAWYQTQ--YEELQVTAGKHGDNLRDTKNEIAELT--
RTVQRLQSE-A--DAAKK------------------------------------------
-----Q-CQ--QLQTAIVDAEQ-RGGLAL-KDAQKKL----GDLDSALHQAKEDLARLLR
DYQALMNVKLALDVEIATYRKLLESEE--------------------------S-RMS-G
ECPSA---V--------SISVTGNSTTVCG------------------------------
-----------------GG--------------AAGFGGGISLGGS---GG--VSKGGFS
TN----------------------------------------VGYGT-------------
KGGPVSG--GTSILRKT--TTVKTSSRRY-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MIARQQSVR-----G-ASRGFSSGSAI-ASG----VKRV-AFSSAS---MSGGA----
-----------------------------------------GRCS-SGGFGSRSLYNLGG
H-KSISMSVAGSCQ-GG-GYGGAGG-----------FGIGGFG-----------------
-------------AG-FG----------------AGGFGGSFG-----------------
---GGFGG----SFN--GRGGPGFP-VC--PAGGI------QEVTINQSLLTPL----QV
EIDPEIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQQQTTTT----SPRSL--DPFFE-TYINALRKHLDSLIN
DKGRLQSELKL-MQDSVEDFKTK-YEDEINKRTA---AENDFVVLK--K---DVDAAYMI
KVDLEAKMDSLKDEINFLRVLYEA-----ELSQMQTHVSDT----SVVLSMDNNRNLDLD
SIIA-EVRAQYEEIAQ-RSKAEVESWYQTK--VQQLQISADQHGDNLKSTKNEISELN--
RMIQRLRAE-I--ENIKK------------------------------------------
-----Q-CQ--NLQTSVADAEQ-RGQTAL-QDAYSKR----AELENALSKAKEDLARLLR
DYQALMNVKLALDVEIATYRKLLEGEE--------------------------C-RMS-G
ECQSA---V--------SISVVGGSASIGG------------------------------
------------------------------------------------------SGL---
---GLGG------------------------GFGSGSG--SGSGFGF--G-GG-------
----VYGSSGTKITSTTTVT--KRSQR---------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQSTVT--FQTGGRRKGFSAASAVTPS-----AGRT-RISSVS-VSRLAW-----
------------------------------------------TGCGGGGFGSRSLYGLGG
S--KRVSISS--------------------------------------------------
------------------------------------------------------------
-------------GGF--FP------VC--PPGGI------QEVTINQSLLAPL----NL
QIDPTIQR--VRKEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWELLQQQGTK----TVRQNL--EPLFD-AYISDLRRQLDTVTA
ERGRLDSELRS-MQDVVEDFKAK-YEDEINKRTA---AENEFVALK--K---DVDGAYMN
KVDLEAKVNSLSDEINFLRVLYEA-----ELSQMQTQISDT----SVVLSMDNNRSLDLD
SIIS-EVKAQYEDIAQ-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKHEISEMN--
RMIQRLRSE-I--DSVKK------------------------------------------
-----Q-CA--SLQTAIADAEQ-RGEMAL-KDARAKL----VDLEDALQKAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEECR---------------------------LS-G
E-----------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------G----VSPV--
-------------------------N--------------VCEY----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--M-SRQSSIT--FQSG-SRRGFSTTSATTPA-----TGRS-RFSSVS-VARSAA--GNG
GLGKIS--------------------------SA------------GASFGSRSLYNLGG
A-KWVSISGC-GSS-----FRSG-------------FGG--RA----SSGFGV-----N-
--------------SGFGYG--GGVGGGF-------------------------------
--------------SGPSFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPTIQR--VRA EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQGSR----TVRQNL--EPLFD-SYISELRRQLESITT
ERGRLEAELRN-MQDVVEDFKVR-YEDEINKRTA---AENEFVALK--K---DVDAAYMN
KVELEAKVKSLPEEINFLHSVFDA-----ELSQLQTQVSDT----SVVLSMDNSRNLDLD
SIIA-EVKAQYEDIAN-RSQAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEISEMN--
RMIQRLRAE-I--DSVKK------------------------------------------
-----Q-CS--SLQTAIADAEQ-RGELAL-KDARAKL----VDLEEALQKAKQDMARLLR
EYQELMNIKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VS-PVNIS--------VVTSTL----------------------------------
------------SSGYGSGS--GIG-----------------------------------
---------------------------------------GGSLGLGGGSG----YSFTT-
-----------------------SG-------GHSLG--A--GLGG-------------S
GFSAT---SNRGLGG------------SGSSVKFV----STTS-----------------
------------------------------------------------------------
------------SSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
----------------------------MNGVNWRS---PPG------SAASTPASTMSI
R--VTQKSYK--VS--TSGPRAFSSRSYTSGPG-----ARI-SSSSF-------------
-------------------------------------------------------SRVGS
-----------------------S-----------SFRGG------------LGG-----
---------------GYG------------------------------------------
-----------------GASG----------MGGI------TAVTVNQSLLSPL----NL
EVDPNIQA--VRT QEKEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQQ-QKT-----ARSNM--DNMFE-SYINNLRRQLETLGQ
EKLKLEAELGN-MQGLVEDFKNK-YEDEINKRTE---MENEFVLIK--K---DVDEAYMN
KVELESRLEGLTDEINFLRQLYEE-----VCSWSQETEG---------------------
----------------------------------------------PPALSTEISEMN--
RNISRLQAE-I--EGLKG------------------------------------------
-----Q-RA--SLEAAIADAEQ-RGELAI-KDANAKL----SELEAALQRAKQDML---R
EYQELMNVKLALDIEIATYRKLLEGEES---------------------------RLE-S
---GM---Q--------NMSIHTKTTSG--------------------------------
---------------YAG---------------------GLSS-----------------
---AYG------------------------------GLTSPGLSYGLG------------
---------------------------------S--------SFGSGA---------GSS
S-----------------------SSSRAVVVKKI------ETRDGKLVSESSDVLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
----------------------------------------------------------MR
-SSVSRQTYST--------KGGFSSNSASGG---AGAGTRT-SFSSVT-VSRSSGSSGR-
--------------------------A--------------HGGPSTGGFGSRSLYNLGG
H-KSISVSVAGGASAG-RAL----------------------------------------
--------------GGFGFG------------------SRAFT-----------------
-------GLG-------AGRQTFGP-AC--PPGGI------QEVTVNQSLLTPL----HV
EIDPEIQR--VRTQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQGQNLG--GTRNNP--EPLFE-AYLGNMRSVLDRLQG
ERGRLDSELRN-VQGLVEDFKNK-YEDEINKRTA---AENEFVVLK--K---DVDAAYMG
QMDLQGKMGTLTQEIDFLQQLYEM-----ELSQVETHVSDT----NVVLSMDNNRSLDLD
SIIA-EVKAQYELIAQ-RSRAEAEAWYQTK--YEELQVTAGKHGDNLRDTKNEIAELT--
RTIQRLQGE-V--DAAKK------------------------------------------
-----Q-CQ--QLQTAIADAEQ-RGEMAL-KDAKNKL----DGLEDALQKAKQDLARLLK
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------S-RMS-G
ECPSA---V--------SISVTGNSTTVRG------------------------------
-----------------GG--------------AAGFGGGISLGGS---GG--GAKGGFS
TN----------------------------------------VGYST----------I--
KGGPVSG--STSILRKT--TTVKTSSRRY-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSCKSTMR--TQ-SSSCRGFSAGSARVPG-----VCRS-GFSSVS-VSRSRGSGGLG
A-------------------------------AC-----------RGAGFGSRSLIGMGG
S-GRISMGGG----SY--AMRSG-------------YGG--RI----GGGFGIGGAA-G-
--------------SGFGFS--AG--A------SS-----------------GF----GF
G--GG-AGFGG-GYGGSGFP------VC--PPGGI------QEVTVNQNLLTPL----NL
EIDPTIQR--VRTEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQGPK----TVTQNL--DSLFE-QYISNLKRQLETFHV
EKGRLDSELRN-VQDTLGDMKKR-YEDEINKRTE---AENEFVTLK--K---DVDAAYLS
KVDLQARADGLSEEINFLRVLYNE-----ELSQMQTQVSNT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEEIAN-HSRAEAESWYRTK--YEELRVTASRHGDDLRNTKQEIAEMN--
RVIQRLRSE-I--DHVKK------------------------------------------
-----Q-NA--NLQASIADAEQ-RGEMAL-KDARNKL----ESLEDALQKAKQDMAQLLK
DYQELLNVKLSLDVEIATYRKLLEGEE--------------------------C-RLQ-G
EG--VG-QV-------N-ISVVQSTV----------------------------------
------------SGGYGGSSG-------------------------V-------------
---------------------------------------SSGLGLGGGSG----YS----
-----------------------YSSG--------------HSLG--------------G
GFSSG---SGRGIG--SGLS--SAGGS-SSTIKYT----TTSS-----------------
------------------------------------------------------------
------------SSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
----------------------------------------------------------MR
-SSVSRQTYSI--------KGGFSSNSASGG---GGSQART-SFSSVT-VSRNSGSGGG-
--------------------------A--------------RCGPSTGGFGSRSLYNLGG
H-RSISVSVAGGNSSG-RAL----------------------------------------
--------------GGFGFG------------------SRAFT-----------------
-------GQG-------AGKQTFGP-AC--PPGGI------QEVTVNQSLLTPL----HV
EIDPEIQR--VRT QEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQGQNLG--ITRNNL--EPLFE-AYLGSMRSTLDRLQS
ERGRLDSELRN-VQDLVEDFKNK-YEDEINKRTA---AENEFVVLK--K---DVDAAYMG
RMDLHGKVGTLTQEIDFLQQLYEM-----ELSQVQTHVSDT----NVVLSMDNNRNLDLD
SIIA-EVKAQYEEIAQ-RSRAEAEAWYQTK--YEELQVTAGKHGDNLRDTKNEIAELT--
RTIQRLQGE-V--DAAKK------------------------------------------
-----Q-CQ--QLQTAIEEAEQ-RGELAL-KDAQKKL----GDLDVALHQAKEDLARLLR
DYQELMNVKLALDVEIATYRKLLESEE--------------------------S-RMS-G
ECPSA---V--------SISVTGNSTTVCG------------------------------
-----------------G---------------------GIALGGN---GG--ATKGGFS
TN----------------------------------------VGYST----------V--
KGGPVSG--GTSILRKT--TTVKTSSRRY-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSCKSTLR--GQG-SSHRSFSTSSARGPG-----LSRS-GFSSVS-VCRTRGSGGSG
A-------------------------------VC-----------GGAGFGSRSLYGLGG
S-RRISMGVS----SC--GIGGG-------------YGS--RV----GGSFG---GV-G-
--------------SGFGFG--GG--A------GA-----------------GL----GF
G--GG-AGLGG-GYGGAGFP------VC--PPGGI------QEVTINQSLLTPL----NL
QIDPTIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVRQNL--EPLFE-QYINNLRRQLDVITA
ERGHLDSELRS-MQDTVEDFKNK-YEDEVNKRTA---AENEFVTLK--K---DVDTAYMN
KVELQTKKDSLIDEINFLRTIYEA-----ELSQMQTRISDM----SVVLSMDNNRNLDLD
SIVA-EVRAQYEEIAQ-RSRAEAEALYQTK--V--------------RKEGQEIAEMN--
RMVQRLRSE-I--DHVKK------------------------------------------
-----Q-GA--SLQSAIADAEQ-RGEMAL-KDARGKL----EGLEDALQKAKQDMARLLK
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RWV-P
TA--QG-GHTIY-------------G----------------------------------
------------HSGYSGA-----------------------------------------
--------------------------------------------LPGGS-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
-----------------------------------------------------------M
SCQISCKSRRG--GGGGGRFRGFSSGSAVVSGG----SRRS-ATSFSC-LSRHGG--GGG
GF-------------------------------------------GGGGFGSRSLVGLGG
T-KSISISVAGGGGSF--GSGGG-------------FGG--RG-----GGFGG-----G-
--------------SGFGGG--GGFGGGSGFGGGSGFGGGGFGGGGFGG--GRF----GG
G--GG-FGGFG-GPGGMGPG------GF--PGGGI------HEVSVNQSLLQPL----NV
KVDPEIQN--VKS QEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWELLQEQGSK----TVRQNL--EPFFE-AYINDLRRQLDSVTT
ERGRLDAELRN-MQDIVEDFKVR-YEDEINKRTT---AENEFVALK--K---DVDSAYMN
KVELEAKVNSLTDEINFLRMLFEA-----ELSQMQTQVSDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEDIAN-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEISEMN--
RMIQRLRAE-I--DSVKK------------------------------------------
-----Q-CS--SLQTAIAEAEQ-RGELAL-KDARAKL----VELEEALQKAKQDMARLLR
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VS-PVNIS--------VVTSTV----------------------------------
------------SSGYGGGS--STG-----------------------------------
---------------------------------------GGSLGLGGGSG----YSFTT-
-----------------------ST-------GHNLG--A--GLGG-------------S
SFSAS---SSRGLGG------------SGSSVKFV----STTS-----------------
------------------------------------------------------------
------------SSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------M--
----SRQASKT--S--GGGSQGFSGRSAVVSG------SSR-M-SC---VTRSGVA-G--
-----GG-------------------------AYGFR----SG---AGGFGSRSLYNLGG
N-KSISISVAAGGS-RAGGFGGGRS------S--CGFAGGYGGGFGGGYGGGFGGGFGGV
--R--GMGGGFGGAGGFG--------GAGGFGGA-----GGFGGPGGFGGPGGFGGPGSF
GSPGGF---------G---P------GG--FPGGI------QEVTINQSLLQPL----NV
EIDPQIGQ--VKAQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQQQSTSSI--SGTNNL--EPLFE-NHINYLRSYLDNILG
ERGCLDSEMRN-MQDLVEDFKKK-YEDEINKRTA---AENEFVTLK--K---DVDGAYMN
KVELQAKVDALIDEINFLRTLYDA-----ELSQMQSHISDT----SVVLSMDNNRSLDLD
SIIA-EVRAQYEDIAQ-RSKAEAEALYQTK--LGELQTTAGRHGDDLRNTKSEIIELN--
RMLQRLRAE-I--ESIKK------------------------------------------
-----Q-NA--NLQTAIVEAEQ-RGEMAL-KDANAKL----QELQAALQQAKDDLARLLR
DYQELMNVKLALDVEIATYRKLLEGEE--------------------------Y-RMS-G
ECPSA---V--------SISVVSSST----------------------------------
--------TSASAGGYAGGYGG-------------GVGGGLGGGL---------------
--------------------GA----GGG-----------SSSGFGRGGG--GGIGG---
---GIGGGF--------------GGGS--------------------SGG--F-SGGSGF
GSSSG--AR-YGVSGGGFSS----ASNRGGSIKFS----QSS------------------
------------------------------------------------------------
----------QSS-QRYSR-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--ATQKSYK--VS--SSGPWAFSSLSFTHAPG-----SRI-SSA-L-------------
-------------------------------------------------------SWVES
----------------------GS-----------SFQRG------------LGI-----
--------------GGYG------------------------------------------
-----------------RPGS----------MGGI------TAVSVNQSLLSPL----KL
EVDPNIQA--VRS QGKEQIKTLNNRFASF------IDK--VR------------------
----HLEQQNK-ILETKWNLLQQ-QKT-----SRSNM--DNTFE-SYIDNLRRQLETLGQ
EKLKLEVELGN-MQGLVEDFNK--Y-EEIKERAD---MENESVLIK--K---DVDE----
-VELESRLEGLTDEINFLRQLYEE-----EIRELQSQISDT----TAVLSMGSSHSLDLD
GIIA-KVKAQYEEIAN-SSQAEAETMYQIK--YEQLQTLA--------------------
-----------EIEGLKN------------------------------------------
-----Q-RA--SLEATIADTKQ-LGELAV-KDANAKV----AELEAALQRAKQDM-----
EYQELMNIKLALDIKITTYCKLLEGEES---------------------------RLE-S
---GM---Q--------NMSIHTKTSTG--------------------------------
---------------YLG---------------------GLVS-----------------
---AYR------------------------------GHMSPGVSHAFQ------------
---------------------------------S--------GFSSGQ---------SSA
SSGHV-------------------SSSKAVVVKKI------ETRDGKLVSQSSDVLSKR-
--TTTVV--PP----SLPAPVAAVEPVGEGAVQGSVG----NERPT--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------MTADAC
G-------------R---STQVFSSRSASLPRR----GAQV-RLTTG----HQGG-----
----------------------------------------------FV--NSRSLYSLG-
------------TS-RPRVSV--GS-----------------------------------
---------------GYG------------------------------------------
----------------G-------P-----VGAGI------REVTINQNLLAPL----RS
NIDPSIRQ--VRQ EERDQIKTLNNKFASF------IDK--VQ------------------
----FLEQQNK-MLETKWALLQEQKST-----KSSSL--PRIFE-AQIAGLRGQLEKLQL
DRGRLEAELRS-MQDVVEDFKNK-YEEEMNHRMA---AENEFVMLK--K---DVDTTYMN
KVDLQAKVDSLSDEINFLKTLHET-----ELAELQSQISDI----SVVLSMDNNRSLDMD
SIIA-EVKAQYEEMAN-RSRAEAEALYQKK--FEILQAQSGKHGEDLRNTRNEIVEMN--
RTIQRLQAE-I--DNIKN------------------------------------------
-----Q-RA--KLEAAIAEAEE-RGELAL-QDARGKQ----EELEAALQQAKQDMARQLR
EYQELMNIKLALDIEIATYRKLLEGEE--------------------------S-RLA-R
DGVGA---A--------NISV---------------------------------------
----VNSS-G---------G----------------GGIGLVFGG-----TMGSNALRFS
S------GGPGT------------------------------------------------
--------IKAYSIRTTSTTRESTHH----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------MDASLPISRISSWFGPPASTPASTMSI
R--VTQKSYK--VST--SGPRAFSSRSYTSGPG-----ARI-SSSSF-------------
-------------------------------------------------------SRVGS
S----------------------------------SFRGG------------LGGGY---
------------------------------------------------------------
-------------------GGAS-------GMGGI------TAVTVNQSLLSPL----NL
EVDPNIQA--VRT QEKEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQQ-QKT-----ARSNM--DNMFE-SYINNLRRQLETLGQ
EKLKLEAELGN-MQGLVEDFKNK-YEDEINKRTE---MENEFVLIK--K---DVDEAYMN
KVELESRLEGLTDEINFLRQLYEE-----EIRELQSQISDT----SVVLSMDNSRSLDMD
SIIA-EVKAQYEEIAN-RSRAEAESMYQIK--YEELQSLAGKHGDDLRRTKTEISEMN--
RNISRLQAE-I--EGLKG------------------------------------------
-----Q-RA--SLEAAIADAEQ-RGELAI-KDANAKL----SELEAALQQAKQDMARRLR
EYQELMNVKLALDIEIATYRKLLEGEES---------------------------RLE-S
---GM---Q--------NMSIHTKTTSG--------------------------------
---------------YGG---------------------GLSS-----------------
---AYG------------------------------GLTSPGLSYGLG------------
--------------------------------SS---------FGSGA---------G--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSV
H-------------F---GSQVFSSRSAALPGR----GAQV-RLSSA----RPGG-----
----------------------------------------------FGN---SSLYGLS-
------------AS-RPRVTL--HS-----------------------------------
---------------AYG------------------------------------------
----------------G-------P-----VSAGI------REVTVNQSLLAPL----TV
DIDPSIQQ--VRQEEREQIKTLNDKFASF------IDK--VR------------------
----FLEQQNK-LLETKWALLQKQKSA-----KSSHL--PGIFE-AQIAALRRQLEVLQV
DGGRLELELRN-TQDVVEDFKNK-YEDEINCRMA---AENEFVVLK--K---DVDAAYMN
KVELEAKVDALNDEINFLKTIYET-----ELTELRAQISDT----SVVLSMDNSRSLDLD
GIIA-EVKAQYEEMAN-RSQAEAEASYQTK--LETLQAQAGKHGDDLRNTRNEIADMN--
RAIQRLQAE-T--DNIKN------------------------------------------
-----Q-RA--KLEAAIAEAEE-NGELAL-KDARAKQ----EELEAALQRAKQDMARQLR
EYQELMNIKLALDIEIATYRKLLEGEE--------------------------S-RLA-G
DGVGA---V--------NISV---------------------------------------
----VNTV-G--------SG----------------GGGGLTFGG-----TMGSNALSFS
SG-----GRPRT------------------------------------------------
--------LRVVSHKTTHRSAHN-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---LSSKTIVR--SQS-SSRCGFSSSSARVPG-----LSRS-GFSSVS-VCRSRGSGGIG
A-------------------------------AY-----------GGAGFGSRSLYGLGG
S-KRISIGGG----SC--AIGGG-------------YGS--RV----GGGFGFGGGA-G-
--------------SGF-----------------------------------------GF
A--GG-VGFGG-GYGGAGFP------VC--PPGGI------QEVTVNQSLLTPL----NM
EIDPTIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVRQNL--EPLFE-QYINNLRRQLDSILG
ERGRLDSELRN-MQDTVEDYKHK-YEDEINKRTA---AENEFVTLK--K---DVDAAYMN
KTELQTKADSLIDEINFLRTLYEA-----ELAQMQTHISDT----SVVLSMDNNRSLDLD
SIIA-EVRAQYEEIAQ-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEIAEIN--
RMIQRLRSE-I--DHVKK------------------------------------------
-----Q-CA--NLQAAIADAEQ-RGELAL-KDARNKL----EGLEDALQKAKQDMARLLK
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLN-G
EG--VG-QV-------N-I-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------GTSLG------------LGRGH---
--------------A---------------------------------------------
------------------GAG---------GMGAI------TAVTVNQSLLSPL----NL
EVDPNIQA--VRTQE-EEIKTLNNKFASF------INK--VH------------------
----FLEQQNK-MLETKWNLLQQ-QTM-----AHSNT--DSMFE-SYINNLQRQLDTLGQ
EKLKLEAELGN-MQGLVEDFKNN-KYCQINKTTK----------NK--K---DVDEAYMN
TVELESCLEGLTDEINILRQLYEE-----EICELQSQILDT----SVV--MDNSCSLDMD
SIIA-EVRTQYEEIAN-CSRAEAESVYQTK--YEELQVQAGKHGDDPQHMKMEISNMN--
WNISRLQNK-I--EVLKG------------------------------------------
-----Q-RA--PPEASIADAEQ-HGELAL-KDAKAKL----TQLEAALSQAKQDMAQQLH
EYQ-LMNGKLALDVEIATYCKLLEGKES---------------------------RLE-S
---GM---Q--------NLSIHTKTTSG--------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSV
H-------------F---SSQVFSSRSAALPSR----GGQV-RLSSG----RPGS-----
----------------------------------------------LG-S--SSFYGLS-
------------AS-RPRVAM--RS-----------------------------------
---------------AYG------------------------------------------
----------------G-------P-----VGAGI------REVTINQSLLAPL----RV
DIDPSIQQ--VRQ EEREQIKTLNDKFASF------IDK--VR------------------
----FLEQQNK-MLETKWALLQESKSA-----KSSRL--SGLFE-AQIAGLRRQLEALQM
DGGRLEVELRS-MQDVVEDFKNK-YEEEINRRTA---AENEFVVLK--K---DVDAAYMN
KVELEAKVDALNDEISFLRTLNET-----ELAELQSQISDT----SVVLSMDNSRSLDLD
SIIA-EVKAQYEEMAK-RSRAEAEAWYQTK--FETLQAQAGKHGEDLRNTRNEIAEMN--
RAIQRLQAE-I--DSIKN------------------------------------------
-----Q-RA--KLEATIAEAEE-HGELAV-RDARAKQ----EEMEAALQQAKQDMARQLR
DYQELLNVKLALDIEIATYRKLLEGEE--------------------------S-RLV-G
DGAGA---V--------NISV---------------------------------------
----VSS----------TGG----------------SGRGLVFGG-----TMGSNALSFS
SS-----GGPGA------------------------------------------------
--------LKAYSIRTSSATRRNLRN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MNRQISKK--SF-SGGSQGFSGRSAVVS-G-----SSR-M-SC---VARTGGA-G--
-----RG-------------------------ACGFR----SGA---GGFGSRSLYNLGG
N-KSISISVA-GGS-RAGGFGGGRG------SCG----SGFGGG----YGGGFGGGFGGG
--R--GMGGGFG-------------------------------GAGGFGGAGGFGGPGGF
GGLGGFGGPG--GFGG---PGGFGP-GG--FPGGI------QEVTINQSLLQPL----NV
EIDPQIGQ--VKAQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQQQTPGSG--SGPQNL--EPFFE-SYISFLRRQLDLVLG
ERGNLEGELKN-MQDLVEDFKKK-YEDEINKRTA---AENEFVGLK--K---EVDAVYMN
KVELQAKADTLTDQLSFLRTLYET-----ELSQMQSHVSDT----SVVLSMDNNRFLDLD
SIIA-EVKAQYEEIAQ-KSKAEAEALYQTK--LGELQSTAGRHGDDLKSTRSEISELN--
RVIQRLRAE-I--ESVKK------------------------------------------
-----Q-NA--NLQTAIAEAEQ-RGEMAL-KDANAKL----QGLQAALQKAKDDLARLLR
DYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RMS-G
ECQSA---V--------SISVVSNVTST--------------------------------
---------SGSSGGSRGGFGGAS-S----SS--GG---YRSS-----------------
---------------SSRGGSGG-YGGISG---------GSSSGYGG-VS-GG---SS--
GGRGSSGSYQ--------------------SSSS------GSRPSSGSSS-----SVSQS
GSSSG--GI-QTSVGSGYKS----GSGGSTSIRFS----QTT------------------
------------------------------------------------------------
----------SSS-QHSSK-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQSSVS--FR-SGGSRSFSTASAITPS-----VSRT-SFTSV---SRSGGG-GGG
GFGRVS--------------------------LG-------GACGV-GGYGSRSLYNLGG
S-KRISISTS----GG--SFRNR-------------FAAG--A----GGGYGFGGGA-G-
--------------SGFGFG--GGAG--------G-----------------GF----GL
G--GGA-GFGG-GFGGPGFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPSIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVRQNL--EPLFE-QYINNLRRQLDSIVG
ERGRLDSELRN-MQDLVEDFKNK-YEDEINKRTT---AENEFVMLK--K---DVDAAYMN
KVELEAKVDALMDEINFMKMFFDA-----ELSQMQTHVSDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEEIAN-RSRTEAESWYQTK--YEELQQTAGRHGDDLRNTKHEISEMN--
RMIQRLRAE-I--DNVKK------------------------------------------
-----Q-CA--NLQNAIADAEQ-RGELAL-KDARNKL----AELEEALQKAKQDMARLLR
EYQELMNTKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VG-PV-------N-ISVVTSSV----------------------------------
------------SSGYGSGS-G--------------YGG--GL----SGG----L-----
---------GGGL--------------------------GGSLA-GGGSG----SYYSS-
------------------------SSG-----GVGLG--GGLSVGG-------------S
GFSAS---SGRGLGVGFGS---GG-G-SSSSVKFV----STTS-S---------------
------------------------------------------------------------
-------------SRKSFKS----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------CTLLHYYSNLSLSTM
A-------------FSSSRQTSFSTRSAVPAAS----FSQM-RISST----RSSSG----
---------------------------------------GAGLGRAGGSFSSSSLSNIGG
GVRK-SVSYGVSSG-RSGGAGFGGA-----------------------------------
---------------GFG---------GAGFG-GA-------------------------
------------GFGGAGFGGGVAY-----SGPGI------QEVTINQSLLAPL----NL
EIDPTIQH--VRQEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWELLQNQKSA-----KASNV--GPLFD-AYIANLRRQLDGLTG
DKGKLEGELRN-MQDLVEDFKNK-YEDEINKRTS---AENEFVVLK--K---DVDAAYMN
KVELEAKMEALTDEINFLRALYEA-----ELRELQEQISDT----SVVLSMDNNRALDMD
SIIA-EVKAQYEDIAN-KSRANAEAVYQNK--FQELQATAGRHGDDLRTTKTEISELN--
RAMQRLQAE-I--ESVKA------------------------------------------
-----Q-RA--KLEAQIAEAEE-RGELAL-KDARTKL----AELEAALQKAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEE--------------------------T-RISEG
P--GP---V--------SVSVVNST-----------------------------------
----SSSM-GGSSSGY-GAG----------------YGSGFGAGGSFSSGGFGSSSTKFG
------SGGSSG------------------------------------------------
--------VKSYSVTTSSSSRSFRQ-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTQKSYK--VST--SGPRSFSSRSYTSGPG-----TRI-SSSAF-------------
-------------------------------------------------------SRVGS
S--------------------S-S-----------SFRGG------------LGSGM---
--------------SL---V----------------------------------------
---------------GGY-GGPS-------GLGGI------TAVTVNQSLLSPL----KL
EVDPNIQA--VRT QEKEQIKTLNNKFASF------IDK--VR------------------
----HLEQQNK-VLETKWNLLQQ-QKT-----ARSNI--DNMFE-SYINNLRRQLETLAQ
EKLKLEVELGN-MQGLVEDFKNK-YEEEIQKRTD---MENEFVIIK--K---DVDEAYMN
KVELESRLEGLTDEINFYRQLYEE-----EIREMQSQISDT----SVVLSMDNSRSLDLD
GIIA-EVKAQYEEIAN-RSRAEAETMYQIK--YEELQSLAGKHGDDLRRTKTEISEMN--
RNISRLQAE-I--EGLKG------------------------------------------
-----Q-RA--SLEAAIADAEQ-RGELAV-KDAQAKL----AELEAALRTAKQDMARQLR
EYQELMNVKLALDVEIATYRKLLEGEES---------------------------RLE-S
---GM---Q--------NMSIHTKTTSG--------------------------------
---------------YSG---------------------GV-------------------
---TYG---------------------------------TPGFNYSLSSY-------Q--
--------------------------------SG--------GLGSVG---------GSG
SFSRT--------------------SSKAVVVKKI------ETRDGKLVSESSDVLSK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------M--
----SRQASKT--S--GGGSQGFSGHSAVVSG------SSR-M-SC---VTRSGVA-G--
-----GG-------------------------AYGFR----SG---AGGFGSRSLYNLGG
N-KSISISVAAGGS-RAGGFGGGRS------S--CGFAGGYGGGFGGGYG----GGFGGV
--R--GMGGGFGGAGGFG--------GAGGFGGA-----GGFGGPGGFGGPGVFGGLGNF
GSPGGF---------G---P------GG--FPGGI------QEVTINQSLLQPL----NV
EIDPQIGQ--VKAQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQQQSTSSI--SGTNNL--EPLFE-NHINYLRSYLDNILG
ERGRLDSEMRN-MQDLVEDFKKK-YEDEINKRTA---AENEFVTLK--K---DVDSAYMN
KVELQAKVDALIDEINFLRTLYDA-----ELSQMQSHISDT----SVVLSMDNNRSLDLD
SIIA-EVRAQYEDIAQ-RSKAEAEALYQTK--LGELQTTAGRHGDDLRNTKSEIIELN--
RMIQRLRAE-I--ESIKK------------------------------------------
-----Q-NA--NLQTAIAEAEQ-RGEMAL-KDANAKL----QELQAALQQAKDDLARLLR
DYQELMNVKLALDVEIATYRKLLEGEE--------------------------Y-RMS-G
ECPSA---V--------SISVVSSST----------------------------------
--------TSASAGGYAGGYGG-------------GVGGGLGGGL---------------
--------------------GA----GGG-----------SSSGFGRGGG--GGLGG---
---GIGGGF--------------GGGS--------------------SGG--F-SGGSGF
GSSSG--AR-YGVSGGGFSS----ASNRGGSIKFS----QSS------------------
------------------------------------------------------------
----------QSS-QRYSR-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--V-QKSYK--VS--TSGTRPFCSCSYTSGPG-----VRI-SSLSF-------------
-------------------------------------------------------SRVGS
-----------------------S-----------SFRGG------------LWW-----
------------------------------------------------------------
---------------------------------GL------TAVPVNQSLLSPL----NL
EVNPNIPA--VRTQEKEQIKTLNNKFASF------VDK--VR------------------
----FLEQQNK-MPETKWSFLQQ-QKT-----AGSNM--DNMFE-SYINSLRRQLETLGQ
EKLKLEAELGN-TQGLVEDFKNK-HEDEINKRTE---MENEFVLIK--K---DVDDAYIN
EVELESCLEG---------QLYEE-----EIRELQSQISDT----SVVLSIDNSRSLDTD
SIIA-EVRVHYEEIAN-CSRAEAESIYQIK--YEELQTL------------TEISEMN--
RNVSWLQAE-T--KGLKG------------------------------------------
-----W-RI--SLEAGIADAEQ-RRQLAI-KDANAKL----SELEAALQQAKSPP-----
---------------------------------------------------------T-G
SCWKM---Q--------NMSIHTKTTSG--------------------------------
---------------YAG---------------------CVSL-----------------
---AYG------------------------------GLTSSGLSYRLG------------
---------------------------------S--------SSRSGA---------GSS
PFSRT-------------------SSTRAMVVKKI------ETRDGKLCGHLGNLLPKCH
FWWHLKP--RT-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTQKSCR--VS--TSGPLAFSSHFYTSGPG-----ACI-SSSSF-------------
-------------------------------------------------------SRVG-
-----------------------------------SFRGS------------LGG-----
---------------GYG------------------------------------------
-----------------GASG----------MGGI------TTVTVNQSLLSPL----NL
EVDPNIQA--VHTQKKEQIKTLNNKFASF------IYK--VQ------------------
----FLEQQSK-MLETKWSLLQQ-QKM-----ARSNM--DNMFQ-SYINNLRRQLETLGQ
EKLKLEAELGN-MQGLVEDFKNK-YEDEINKRTE---MENEFVLIK--K---DVDEACMN
KVELESRLEGLTDEINFLRQLYGE-----DSPELQSRA--M----SVVLSMDNNHSLDVD
SIIN-EVNHS---------R-------------VEAES-----------------MYQ--
IKYDRLQAE-I--EGLKG------------------------------------------
-----Q-RA--SLEAAIADAEQ-RRELAV-KDASAKL----SELEAALQQAKQDM-----
-YQELMNVKLALDIEIATYRKLLEGEES---------------------------WLE-S---GM---Q--------SMSIHRKTASS-----------------------------------------------YAG---------------------GLSS--------------------AYG------------------------------GLTSPGLSYGLG---------------------------------------------S--------SFGSGA---------GSSSFSCT-------------------SYTRAVVMKKI------ETRDGTLVSESSDVLPK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YQ--IKYDRLQAE-I--EGLKG-----------------------------------------------Q-RA--SLEAAIADAEQ-RRELAV-KDASAKL----SELEAALQQAKQDM------YQELMNVKLALDIEIATYRKLLEGEES---------------------------WLE-S
---GM---Q--------SMSIHRKTASS--------------------------------
---------------YAG---------------------GLSS-----------------
---AYG------------------------------GLTSPGLSYGLG------------
---------------------------------S--------SFGSGA---------GSS
SFSCT-------------------SYTRAVVMKKI------ETRDGTLVSESSDVLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQSSVS--FR-SGGGRSFSAASAITPS-----VSRT-SFTSV---SRSGGG-GGG
GFGRVS--------------------------IR-------GAG-GAGGYGSRSLYNLGG
S-KRISMSSS--------SIRNQ-------------FANGAGY----GFGFGSGSGA-G-
--------------SGFGFG--GGSSWF--G-GVG-----------------GY----GN
M--RG-MGFGS-GAGGPGFP------VC--PPGGI------QEVTINQSLLTPL----NL
QIDPTIQR--VRTEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVRQNL--EPLFE-QYINNLRRQLDGVLG
ERGRLDSELRN-MQDLVEDFKNK-YEDEINKRTT---AENEFVMLK--K---DVDAAYMS
KVELEAKVDALMDEINFLKMFFEA-----ELSQMHTHISDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEDIAN-RSRTEAESWYQTK--YEELQRTAGQHGDDLRSTKHEISEMN--
RMIQRLRAE-I--DNVKK------------------------------------------
-----Q-CA--NLQNAIAEAEQ-RGEMAL-KDARNKL----AELEDALQKAKQDMARLLR
DYQELMNTKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VG-PV-------N-ISVVTSNV----------------------------------
------------SSAYGGGSSGGYGG----G---AGLGS--GLG----------L-----
-----GGGLIGI----------------------HGGSFGGGH------G----SSFGG-
-----------------------SSGG-----LFGGG--SFVPMPG-------------M
GFGSSVSGGGSGSGGGSGS----GGG-SASSVKFV----STTS-S---------------
------------------------------------------------------------
-------------SRKSFKS----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--M-SRQSSIT--FQSG-SHRGFSTTSATTPA-----AGRS-RFSSIS-VARSAV--GSG
GPGRIS--------------------------SA------------GAGFGSRSLYNLGG
T-KRVSINGC-GSS-----FRSS-------------FGG--RA----SGGFGV-----S-
--------------SGFGYG--GGVGGGF-------------------------------
--------------SGPGFP------VC--PTGGI------QEVTVNQSLLTPL----NL
QIDPTIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQGSR----TVRQNL--EPLFE-SYISELRRQLESITT
ERGRLEAELRN-MQDVVEDFKVR-YEDEINKRTA---AENEFVALK--K---DVDAAYMS
KVELEAKVKSLPEEINFLHSVFDA-----ELSQMQTQVSDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEDIAN-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEISEMN--
RMIQRLRAE-I--DSVKK------------------------------------------
-----Q-CS--SLQTAIADAEQ-RGELAL-KDARAKL----VDLEEALQKAKQDMARLLR
EYQELMNIKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VS-PVNIS--------VVTSTV----------------------------------
------------SSGYGSSS--GIG-----------------------------------
---------------------------------------GGSLGLGGGSG----YSFTT-
-----------------------SG-------GHSLG--A--GLGG-------------S
GFSAT---SSRGLGG------------SGSNVKFV----STTS-----------------
------------------------------------------------------------
------------SGRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MNRQVCKT--S--GGGSQGFSGRSAVVSG------SSR-M-SC---VARTGRS-G--
-----GG-------------------------SCGFR----SG---AGGFGSQSLYNLGG
N-KSISYSVAGGSRGGSFGYGSGRS------ICGGGFRGG-----------GFGGGFGG-
-------AGGFGGAGGFG--------------G-------GFGGAGGFGGAGGFGGLGGF
GGAGGF---------G---PGGFGP-GG--FPGGI------QEVTVNQSLLQPL----NV
EIDPQIGA--VRTQEREQIKTLNNKFATF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQQQGVNSV--TGTNNL--EPLFE-SYISNLRRTLDGLQG
ERGKLDGELRS-MQELVEDFKRK-YEDEINKRTA---AENEFVTLK--K---DVDAAYMN
KVELQSRVDGLTDEINFLRVLYEA-----ELSQMQTHVSDT----SVILSMDNNRSLDLN
SIIA-EVQAQYEEMVE-RSKAEANELYQTK--LGELQNKAGRHGDDLKSTKSEIMELN--
RMIQRLRAE-I--ENVKK------------------------------------------
-----Q-NA--KLQAAIAEAEQ-RGELAL-KDAQAKL----QGLQSALQKAKDDLARLLR
DYQELMNVKLALDVEIATYRKLLEGEE--------------------------CSRMS-G
EFQNP---V--------SISVVSSNTS---------------------------------
--------TSMSGGGYGGG-FGGG------------------------------------
-----------------------------R---------GAGSGFGGGSG-S-SFG----
------G--GSGF-----------------------------GGGSGSGF--GSSSSSSF
G--SG--GR-SRVSGGGISS----GSIRGGS-----------------------------
------------------------------------------------------------
----------IKY-SQSSRSSR--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSSKSIRK--SQ-TITHCGFSAGSARLPG-----AGRS-GFSSIS-VSRSRGSGGLG
G-------------------------------AC-----------GGAGFGSRSLYNLGG
S-KRISIGGG----SC--AISGG-------------YGG--RV----GGGFGFGGGA-G-
--------------SGFGFG--GA--A------GA-----------------GF----GL
G--GG-AGFVG-GYGGSGFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPTIQR--VRTEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVRQNL--EPLFE-QYINNLRRQLDSILG
ERSRLDSELRG-MQDLVEDFKNK-YEEEINKRTA---AENEFVTLK--K---DVDAAYMN
KVELQAKVDSLTDEINFLRAFYDA-----ELAQMQTHISDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEEIAQ-RSRAEAESWYQSK--YEELQVTAGRHGDDLRNTKQEISEIN--
RMIQRLRSE-I--DHVKK------------------------------------------
-----Q-CA--NLQTAIADAEQ-RGEMAL-KDAKNKL----AGLEDALQKAKQDMARLLK
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VG-QV-------N-ISVVQSTV----------------------------------
------------SGGYGG-------------------------SSSV-------------
---------------------------------------GGGVGLGGGSS----YS----
-----------------------YGSG-----I---G--G--------------------
GFSSG---SGRGIG--SGFS--STGGG-SSTIKYT----TTS--T---------------
------------------------------------------------------------
------------SSRKSYQH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------CSPLRGL----SVF-VPLVLTMSI
RST-THRTIK--VST--SGPRSFSSRSYSSGPS-----SRI-STSSF-------------
-------------------------------------------------------SRVGG
S----------------------S-----------SYRSG------------FGIGT---
--------------G---------------------------------------------
---------------MGFAGSSS-------GVGGI------TAVSVNQNLLSPL----KL
ELDPNIQA--VRTQEKEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQQ-QKT-----SRSNM--DSMFE-SYIANLRRQLDSLGQ
EKLKLEVELSN-MQGLVEDFKNK-YEEEINKRTE---MENDFVLIK--K---DVDEAYMN
KVELESRLEGLTDEINFLRKLYEE-----EIRELQSQISDT----SVILSMDNSRSLDLD
GIIA-EVRAQYEDIAN-RSRAEAESMYQIK--YEELQTLAGKHGDDLRHTKMEIAEMT--
RNINRLQAE-I--EGLKG------------------------------------------
-----Q-RA--ALEASITDAEQ-RGELAI-KDAQAKL----AELESALQRAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEES---------------------------RLE-S
---GM---Q--------NLSIHTKTTRG--------------------------------
---------------DY--------------------SSGFSS-----------------
---GYG------------------------------SLTGPSLNYGLS--------SY--
---------------------------------Q--------S----------------S
PSTYS-------------------RVSKAVVVKKI------ETRDGKLVSESSDILPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--M-SRQSTIT--FHSGGSRRGFSTASATTPA-----TGRS-RFSSVS-VARSSG--NSG
GLGRIG--------------------------GG------------GAGFGSRSLYNLGG
T-KRVSIGGYAGSG-----FRSG-------------FGG--RA----SGGS---------
---------------GFG------YGGGF-------------------------------
--------------GGPGFP------AC--PSGGI------QEVTVNQSLLTPL----NL
QIDPTIQR--VRK EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQEQGSR----TVRQNL--EPFFD-AYLNDLRRQLDGVTA
ERGRLDAELRS-MQEVVEDFKVR-YEDEINKRTA---AENEFVGLK--K---DVDGAYMN
KVELEAKVDSLTDQINFYRMIYEA-----ELSQMQNQVSDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEDIAN-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEISEMN--
RMIQRLRSE-I--DAVKK------------------------------------------
-----Q-CA--SLQTAISDAEQ-RGELAL-KDARAKL----VDLEDALQKAKQDMARLLR
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VS-PVNICEY--DPCAVVTSTV----------------------------------
------------SSGYGGGS--NIG-----------------------------------
---------------------------------------GGSLGLGGSSG----YSFTT-
-----------------------SG-------GHSLG--T--GLGG-------------S
GFTTS---SSRGPAG------------SGSSIKFV----STTS-----------------
------------------------------------------------------------
------------SSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
MTSKSTTRIQS--TS-SSSRRGFSASSARAPG-----LCRS-GFSSMS-VSRSRGSGGMG
A-------------------------------SC-----------RGTGFGSRSLYGTGV
S-KRISIGGG----SC--AMGGG-------------YGS--GV----GGGFGFGGGA-G-
--------------SGFG-----------------------------------------L
G--GA-AGLGG-GYGGAGFP------VC--PPGGI------QEVTINQNLLTPL----NL
EIDPTIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVRQNL--EPLFE-QYISNLRRQLDSILG
ERGRLDSELRS-MQDLVEDYKNK-YEDEINKRTA---AENEFVTLK--K---DVDAAYMN
KVELQAKADSLTDEINFLRVLYDA-----ELSQMQTHISDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEEIAQ-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEIAEIN--
RMIQRLRSE-I--DHVKK------------------------------------------
-----Q-CA--SLQAAIADAEQ-RGEMAL-KDAKSKL----EGLEDALQKAKQDMARLLK
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VG-PV-------N-ISVVQSTV----------------------------------
------------SSGYGSAGG-------------------------S-------------
---------------------------------------GSGFGLGGGSS----YS----
-----------------------YSSG--------------HGLG--------------G
GFSSG---SGRGIG--GGLS--SSGGS-SSTIKYS----STTS-----------------
------------------------------------------------------------
--------------SRSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MIARQQGIR-----G-SSRGFSSGSAI-IGG----GKRV-AFSSAS---MSGGA----
-----------------------------------------GRCS-SGGFGSRSLYNLRG
S-KNISCGVAGPRQ-GA-GFGCAGG-----------YG----------------------
-------------TGSFG----------------AGFGIGGFG-----------------
---GGFGS----SFN--GRVGPGFP-VC--PAGGI------QEVTINQSLLTPL----HV
EIDPEIQK--VRT EEREQIKILNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWKLLQQQTTTT----SSRNL--DNFFE-TYISALRKQLDALVN
EKGRLQSELKM-MQDSVEDFKTK-YEDEINKRTS---AENDFVVVK--K---DVDAAYMN
KVELGAKVDGLNDEVNFLRVLYEA-----ELSQIQSHVSDT----SVVLSMDNNRDLDLD
SIIA-EVRAQYEEIAQ-RSKAEVEAWYQTK--VQQLQTSVDQHGDNLKSTKNEISELN--
RMIQRLRVE-I--ENIKK------------------------------------------
-----Q-CQ--TLQTSVADAEQ-RGELAL-KDAYSKR----TELEVALQKAKEELARMLR
EYQELLSVKLALDIEIATYRKLLEGEE--------------------------C-RMS-G
ECQSAVSIS--------V---VGGSVSTG-------------------------------
-------------------------------------------------------GG---
---GFGL------------------------GAGLGSG--SGSGFGF--S-GS-------
----VGGSSGGKIISTTTTLT-RRSQR---------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--TMSCKSTVK--TQ-SISRRGFSAGSARVPG-----VCRS-GFSSVS-LSRSRGSGGLA
G-------------------------------VC-----------GGAGFGSRSLYGLGG
S-KRISIAGG----SC--VIGGG-------------YGG--RI----GVGYGFGGGA-G-
--------------SGFGFG--AG--A------GS-----------------GF----GL
G--GG-AGFGG-GFGGPGFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPTIQR--VRTEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTR----TVRQNL--EPLFE-QYINNLRRQLDSILG
ERGRLDSELRG-MQDTVEDFKNK-YEDE--------------------------------
--------------INFLRTFYDA-----ELAQMQTHISDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEEIAQ-RSRAEAESWYQSK--YEELRVTAGRHGDDLRNTKQEISEIN--
RVIQRLRSE-I--DHVKK------------------------------------------
-----Q-CA--SLQSAIADAEQ-RGELAL-KDARNKL----AGLEDALQKAKQDMARLLK
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VG-QV-------N-ISVVQSTV----------------------------------
------------SGGYGGAGGY-----------------GG--ASGL-------------
---------------------------------------GSGLGVSGGSG----YS----
-----------------------YSSG------HSLG--G--------------------
GFSSG---SGRAIG--CGFG--SSGGS-SSTIKYT----TTT-SS---------------
------------------------------------------------------------
------------SSRKGYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------MSIHFSSRSATFPGR----STQV-RLSSA----SRGG-----
----------------------------------------------FGGSSSLYGLGLG-
------------AS-RPLVAV--RS-----------------------------------
---------------AFG------------------------------------------
----------------S-------P-----VGASI------REVTVNQNLLAPL----RV
DIDPSIQR--VRQEEREQIKTLNDKFASF------IDK--VR------------------
----VLEQQNK-LLETK-ALLQEQKSA-----KGSRL--PSVFE-AQIAGLKGQLEALQV
DGGRLEVEXXX-XXXXXXXXXXX-YEDEINGRTA---AENEFVVLK--K---DVDAAYMN
KVELEAKVDALNDEINFLKNINET-----ELTELQSQIQDT----SVVLSMDNSRSLDLD
SIIA-EVRTQYEDMAN-RSRAEAETWYQTK--FETLQAQAGKHGDALRNTRNEIAEMN--
RAIQRLQAE-I--NNVKN------------------------------------------
-----Q-CA--KLEAAITEAEE-RGELAL-KDARAKQ----KELEAALQRAKQDMARQLR
EYQELMNTKLALDIEIATYRKLLEGEE--------------------------S------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
----------------------------------------------------------MR
S-SVSRQTYST--------KGGFSSNSASGG---GGSRIRT-SYSSVT-MSRSSGS--G-
--------------------------G---GV---------RSCPGSGGFGSRSLYNLGG
--KNISVSVAGGTSSG-RAL----------------------------------------
--------------GGFG--------------------TGAYL-----------------
-------GLG-------AGRQTFGP-VC--PPGGI------QEVTVNQSLLTPL----NV
EIDPEIQR--VRT QEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQSQNTG--VTR-NL--EPLFE-TYLSNLRRQLDAKQS
EHGRLDMELRS-VQDNLEDFKNK-YEDEINKRTA---LENEFVLLK--K---DVDAAYMG
RMDLHGKVDTLTQEIDFLQHLFEM-----ELSQVQTHVSDT----NVVLSMDNNRSLDLD
SIIA-EVKAQYELIAQ-KSRAEAESWYQTK--YEELQVTAGKHGDSLRDTKNEIAELT--
RTIQRLQGE-V--DATKK------------------------------------------
-----Q-CQ--QLQTAIAEAEQ-RGEMAL-KDAKKKL----GDLDTALHQAKEDLARLLR
DYQSLMNVKLALDVEIATYRKLLESEE--------------------------S-RMS-G
ECPSA---V--------SISVTGNSTSVCA------------------------------
-----------------GG--------------AAGFGSGLSLGGA---GG--ANKGSFS
AN----------------------------------------VSYGT----------A--
KGGQVSG--GTSILRKT--TTVKTSSRRY-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------DVDAAYMN
KVELQAKADTLTDEINFLRALYDA-----ELSQMQTHISDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEEIAQ-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEIAEIN--
RMIQRLRSE-I--DHVKK------------------------------------------
-----Q-CA--SLQAAIADAEQ-RGEMAL-KDAKNKL----EGLEDALQKAKQDLARLLK
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLN-G
EG--VG-QV-------N-VSVVQSTV----------------------------------
------------SSGYGGASG-------------------------V-------------
---------------------------------------GSGLGLGGGSS----YS----
-----------------------YGSG--------------LGVG--------------G
GFSSS---SGRAIG--GGLS--SVGGG-SSTIKYT----TTSS-----------------
------------------------------------------------------------
------------SSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTQKSYK--VS--TSGTLAFSSRSYTGGPG-----AHV-SFSSF-------------
-------------------------------------------------------SRVGS
-----------------------S-----------SFWGG------------PGG-----
---------------GYG------------------------------------------
-----------------GASG----------LGGI------TAVMVNQSLLSRL----NL
EVDPNIQ A--MCT QEKEQIKTLA-KFVSV------IDK--VR------------------
----FLGQQIK-MLEPKWSLLQQ-QEM-----AQSNM--GDMFE-SYINNLRRQLETLGQ
EKLKLETELGN-MQGLVEDFKNE-NEDEINKGKE---MANEFVLIK--K---DVDEAYMN
RVELESRLDGLSNEINFLRELHEE-----EIRELHSQISDT----SVVL-----------
-IIA-EVKVQYEEIAN-RSLAEAESIYQVK--YEELQMLAAKHGDDLRRTKTEISEMK--
RNISWLQAE-I--DGLKG------------------------------------------
-----Q-MV------AIAHAEQ-RGELAV-KDANVKL----SELEATLQRAKQDMARQLR
EYQELMNVKLALDIEIATYRKLQEGEES---------------------------QLE-S
---G--------------------------------------------------------
------------------------------------------------------------
---------------------------------------IPGLSYGLG------------
---------------------------------S--------SLGSGA---------GSS
SFSRT-------------------SSTRALAVKKI------ETRDGKLGSASSDVLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSIRPYK--VS--ISDPQAFSSCSYTSGPS-----AHI-SSS---------------
---------------------------------------------------------MGS
-----------------------S-----------SFQGV------------LGG-----
---------------GCG------------------------------------------
-----------------GASG----------MGGI------TAVTVSQSLLSPL----NL
EVDPNI QT--THT QEKEQIKSLNKKFASF------IDK--VQ------------------
----FLEQQNK-MLETKWSLLQQ-HNT-----AWSNM--DNTFK-SYINNLWQQLDTLGQ
ETLKLLAGLGN-NQGLVEDFKNK-YEDEINKRTE---MENEFVLIK--K---DVVEAYIN
KVELESGLEALTDEINFFRQL------------------------SVALSMDNSRSLDMD
SIIA-EVKAQYEEITN-RSRAEVDSMHQIK--DEELQMLAGKHGDDLQHTQTEISEMN--
QNISWLQAE-I--EGLKG------------------------------------------
-----Q-RA--SLEAAIADAKQ-HRELAV-KDANAKL----SEPEAALQWAKQDMAQQLP
EYQELMNVKLALDMEIATYRKLLEGEES---------------------------RLA-S
---GM---Q--------NMSIHTKTTSG--------------------------------
---------------YAN---------------------GLSS-----------------
---GYK------------------------------GITSPSLSL---------------
------------------------------------------CFGSGG---------GSS
SFSHT-------------------SSTSAMVVEKM------ETCDGKLVSKSSDILPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSMTSYK--VS--TSGPRGFSSHSYMSGPG-----ACI-SSLSF-------------
-------------------------------------------------------SRVGS
-----------------------R-----------SFQGG------------LAR-----
---------------GYG------------------------------------------
-----------------GAS--------------I------TAVMVNQSLLSPL----NL
VVDLNIQA--VSTQE-EQIKTFNNKFASF------IDK--VQ------------------
----YLKQQK--MLETKWSLLVQ-HKM-----ARSNM--DNMLE-NYINNLRRQLETLGQ
EKLKLEAELCN-MQGLM---------------------ENEFVLIK--K---DVDETYMN
KVELESRLEGLTDEINFLRQLYEE-----EIQELQSQISDT----SVVLSMYNSHSLDMD
SIIA-EVKAHYEETAN-SSQAEAESMYQIK--YEELQTLAGKHRDDLRCPKTENSETN--
WNISQFRAERI--EGLKG------------------------------------------
-----Q-RA--SLEAAIADAEQ-PGELAV-KDANAKL----SELEAALQQAKQDLVWQLC
EYPELMNVKLALDIEIATYRKLLEGEES---------------------------RLE-S
---GM---Q--------NMSIHMKTTSG--------------------------------
---------------YAG---------------------GLSL-----------------
---ASG------------------------------GLTRLSLG----------------
---------------------------------------------YGM---------GSS
SFSCT-------------------SSIRAMVVKKI------ETRDGKLVSESSDVLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSM
R--VTQKTYK--VS--TSGPWAFSSLSYTSGLG-----SHI-SSSSF-------------
-------------------------------------------------------SQMGS
S----------------------S-----------SFRGS------------LGS-----
--------------GRLW------------------------------------------
-----------------R-GS----------------------IQVNQSLLNPL----NL
EVDPNIQA--VHIQEKEQIKTLNNKFASF------VDK--VW------------------
----FLEQQNK-MLETKWSLLQQ-QKT-----FRSNM--DNMFE-SYINNLQWQLDAMGQ
EKSKLEAELGN-MQGLVEDFKNK-YENEINKPTE---MENEFVLIK--K---DVDETYMN
KEELESCLERLTDEINFLRQLYEE-----EIRELQSQISDT----SVVLSMDNSHSLDLD
T--------QFEEIAN-HSPAKAESMYQIK--FEEFQTLAGKDGDDLCCTKCEISEMN--
SSISCFQVE-I--EAPKG------------------------------------------
-----Q-RA--SLEAAITDAEQ-CGELAI-KDANAKL----AQLEAALQKAKQDMAWQLH
EDQELMKVKLI-----STYHKLLEGEEN---------------------------RLE-A
---GM---Q--------NMSIHTKTTSG--------------------------------
---------------NSG---------------------MVSS-----------------
---PYG------------------------------SLPSPGFGSLQS------------
-----------------------------------------------------------P
GFTQM---------------------KSAVLAALFIQYIGRNKCNK--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTQKSYR--VST--SGPRAFSSCSFTSGPS-----ARS-SSSSF-------------
-------------------------------------------------------SRVSS
T----------------------------------DFRGG------------LGAGY---
--------------A---------------------------------------------
------------------GASGI-------GPGGI------TAVTINQSLLNPI----KL
DMDPNIQA--VRT QEKEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQQ-QKT-----AQSNM--DNMFE-SYINNLRRQLETLGQ
EKLKLEAELGN-MQGLVEDFKNK-YEEEINKRTE---VENEFVLIK--K---DVDEAYMN
KVELESRLEGLTDEIHLLRQLYEE-----EIRELQSQISDT----SVVLSMDNNHSLDMD
SIIA-EVKAQYEEIAN-RSRAEAESLYQIK--YEELQKL------------TEISEMN--
WNVSRLQAE-I--EGLKG------------------------------------------
-----Q-RA--SLEAAIIDAEH-RGEQAL-KDAHAKQ----QQLEEALQKAKQDMARQLR
DYQELMNVKLALDIEIATYRKLLEGEES---------------------------RLE-S
---GM---Q--------NMSIHTKTTSG--------------------------------
---------------YAG---------------------GLSS-----------------
---AYG------------------------------GLTSPSLSYSLG------------
---------------------------------S--------SIGSGV---------DS-
TFSRT-------------------SSTKAVVVKKT------ETRDGRLVSESSEVLPT--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSR
NFS-SRSGRR---IG-----GGFSSGSAGVVS-----FQRR-TTSSS--VCRGGGGG---
G--GFS------------------------GGRYGAG--C-----AGGGFGSRSLVNLGG
N-KSISISVARGGG-R-SGFGGG---------Y-G---GGGFGV------GGYGG-----
--------------GGF-----GG----GGFG-SGGFGGGGFG-----------SGGFG-
G---------G-GFGGGGFRGGFGP-VC--PPGGI------QEVTINQSLLQPL----NV
EIDPEIQR--VKSQEREQIKTLNNQFASF------IDK--VR------------------
----FLEQQNQ-VLQTKWELLQQVDTPT----RTQSL--EPIFE-AYISSLRRQVDQLKS
DQSRMDSELKN-MQDVVEDYRNK-YEEEINKRTN---AENEFVTIK--K---DVDAAYIT
KVDLQAKVDNLRQEIEFLRILYQE-----ELSQLQTHISDT----NVILSMDNNRHLDLD
SIIA-EVRAQYEDIAQ-KSKAEAEALYQSK--YEELQITAGSHGDSLKSTKMEISELN--
RVIQRLRSE-I--DSVKK------------------------------------------
-----Q-IA--ALQQSITEAEQ-RGENAL-KDAQNKL----NELEDALQRAKEDLARLLR
DYQELMSTKLALDVEIATYRTLLEGEE--------------------------S-RMS-G
ECAP-N--V--------SVSVSTSHTSISG------------------------------
------------GGV--RGG--GGFS----SGGGGSYSSG-----------GGSYSS---
---GGGVGGQ-RG------------------------ALSGGGGSYM-SG-GGSYSSGGG
-GG----GFGS-----------GGSSRGH-RGGS------GGGSGSYGV-R-ISGGGGSG
GSFSS--S-----GGRGVSSGGSKSSGGSSSVKFV----SSS------------------
------------------------------------------------------------
----------YSQ-GSR-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQASKT--S--GGGSQGFSGRSAVVSG------SSR-M-SC---AARSGGA-G--
-----GG-------------------------AYGFR----SG---AGGFGSRSLYNLGG
N-KSISISVAAGGS-RAGGFGGGRS------SCG--FAGGYGGGFGGGYGGGFGG----G
RG----MGGGFGGAGGFG--------------GA-----GGFGGAGGFGGPGGFGGPGVF
GGPGSFG--------S---PGGFGP-GG--FPGGI------QEVTINQSLLQPL----NV
EIDPQIGQ--VKA QEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQQQGTSSI--SGTNNL--EPLFE-NHINYLRSYLDNILG
ERGRLDSELKN-MEDLVEDFKKK-YEDEINKRTA---AENEFVTLK--K---DVDSAYMN
KVELQAKVDALIDEIDFLRTLYDA-----ELSQMQSHISDT----SVVLSMDNNRSLDLD
SIIA-EVRAQYEDIAQ-RSKAEAEALYQTK--LGELQTTAGRHGDDLRNTKSEIIELN--
RMIQRLRAE-I--EGVKK------------------------------------------
-----Q-NA--NLQTAIAEAEQ-HGEMAL-KDANAKL----QELQAALQQAKDDLARLLR
DYQELMNVKLALDVEIATYRKLLEGEE--------------------------YS-----
------------------------SST---------------------------------
--------TSASAGGYGGG-YGGG------------LGGGLGG-----------------
--------------------GF----SAGG---------GSGSGFGRGGG-G-GI-----
---------GGGF-----------------------------GGGSSSGF--SGGSGF--
GSISG--AR-YGVSGGGFSS----ASNRGGSIKFS----QSS------------------
------------------------------------------------------------
----------QSS-QRYSR-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
----------------------------------------------------------MR
-SSVSRKTYST--------KGGFSSNSASGG---GGSQART-SFSSVT-VSRNSGSGGG-
--------------------------T--------------HCGPSTGGFGSRSLYNLGG
H-KSISVSVAGGASLG-RAL----------------------------------------
--------------GSFGFG------------------SRAFT-----------------
-------GQG-------AGRQTFGP-AC--PPGGI------QEVTVNQSLLTPL----HV
EIDPEIQR--VRT QEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQGQNLG--ITRNNL--EPLFE-AYLGSMRSTLDRLQS
ERGRLDSELRN-VQDLVEDFKNK-YEDEINKRTA---AENEFVVLK--K---DVDAAYMG
RMDLHGKVGTLTQEIDFLQQLYEM-----ELSQVQTHVSDT----NVVLSMDNNRNLDLD
SIIA-EVKAQYELIAQ-RSRAEAEAWYQTK--YEELQVTAGKHGDNLRDTKNEIAELT--
RTIQRLQGE-V--DAAKK------------------------------------------
-----Q-CQ--QLQTAIEEAEQ-RGELAL-KDAQKKL----GDLDVALHQAKEDLARLLR
DYQELMNVKLALDVEIATYRKLLESEE--------------------------S-RMS-G
ECPSA---V--------SISVTGNSTTVCG------------------------------
-----------------G---------------------GISLGGN---GG--ATKAGFS
TN----------------------------------------VGYST----------V--
KGGLVSG--GTSILRKT--TTVKTSSRRY-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
----------------------------------------------------------MR
-SSLSRQTYST--------KGGFSSNSASGG---GGCRTRT-SFSSVT-MSRSSGGGGG-
--------------------------A--------------RCGPSTSGFGSRSLYNLGG
S-KSISVSVAGGASSG-RAL----------------------------------------
--------------GGFGFG------------------SGAYM-----------------
-------GLG-------AGRQTFGP-AC--PPGGI------QEVTVNQSLLTPL----NV
EIDPEIQR--VRTQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQSQNMG--VTRNNL--EPIFE-AFLSSLRRQLDSKQD
ERGRLDLELRN-VQDLLEDFKNK-YEDEINKRTA---LENEFVVLK--K---DVDAAYMG
RMDLHGKVDSLTQEIDFLQALYEM-----ELSQVQTHVSDT----KVVLSMDNNRSLDLD
SIIA-EVKAQYELIAQ-RSRAEAEAWYQTK--YEELQVTAGKHGDTLQNLRDEISELT--
RIIQRLEIE-L--EAAKK------------------------------------------
-----Q-CQ--KLQAAIEEAEQ-RGEMAL-KDAKKKL----GDLDTALHQAKENLARLLR
DYQALMNVKLALDVEIATYRKLLESEE--------------------------S-RMS-G
ECPST---V--------SISVTGNSTTMVG------------------------------
-----------------GS--------------AAGFGGGVSLGGS---GG--GFKAGFS
TN----------------------------------------VGYSN----------V--
KGGVGSG--GTSILRKT--TTVKTSSRRY-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
----------------------------------------------------------MR
-SSISRQTYST--------KGGFSSNSASRG---SGSQART-SFSSVT-VSRSSGSGGG-
--------------------------A--------------RCGPGTGGFGSRSLYNLAG
H-KSISVSVAGGASSG-RAL----------------------------------------
--------------GGFGFG------------------SRAFM-----------------
-------GQG-------AGRQTFGP-AC--PPGGI------QEVTVNQSLLTPL----HV
EIDPEIQR--VRT QEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQGQNLG--VTRNNL--EPLFE-AYLGSMRSTLDRLQS
ERGRLDSELRN-VQDLVEDFKNK-YEDEINKRTA---AENEFVVLK--K---DVDAAYMG
RMDLHGKVGTLTQEIDFLQQLYEM-----ELSQVQTHVSDT----NVVLSMDNNRNLDLD
SIIA-EVKAQYELIAQ-RSRAEAEAWYQTK--YEELQVTAGKHGDNLRDTKNEIAELT--
RTIQRLQGE-A--DAAKK------------------------------------------
-----Q-CQ--QLQTAIAEAEQ-HGELAL-KDAQKKL----GDLDVALQQAKEDLTRLLR
DYQELTNVKLALDVEIATYCKLLESEE--------------------------S-RWW-P
LLPDP------------ESSVTGKSTNVCG------------------------------
-----------------GG--------------AASFGGGISLGGS---GG--ATKGGFS
TN----------------------------------------VGYGT----------V--
KGGPVSG--GTSILRKT--TTVKTSSQRY-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MIARQQCVR-----G-GPRGFSCGSAIVGGG----KRG--AFSSVS---MSGGA----
-----------------------------------------GRCS-SGGFGSRSLYNLGG
N-KSISMSVAGSRQ-GA-CFGGAGG-----------FGTGGFG-----------------
------A-------SGFGA----------------GFSTGGFG-----------------
---GGFGG----SFS--GKGGPGFP-VC--PAGGI------QEVTINQSLLNPL----HV
EIDPEIQK--VRT EEREQIKLLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQQQTTTT----SSKNL--EPLFE-TYLSVLRKQLDTLGN
DKGRLQSELKT-MQDSVEDFKTK-YEEEINKRTA---AENDFVVLK--K---DVDAAYMN
KVELEAKVDSLNDEINFLKVLYDA-----ELSQMQTHVSDT----SVVLSMDNNRNLDLD
SIIA-EVRAQYEEIAQ-RSKAEAEALYQTK--VQQLQISVDQHGDNLKNTKSEIAELN--
RMIQRLRAE-I--ENIKK------------------------------------------
-----Q-CQ--TLQASVADAEQ-RGENAL-KDAHSKR----VELEAALQQAKEELARMLR
EYQELMSVKLALDIEIATYRKLLEGEE--------------------------Y-S----
-----------------------GSTSTGG------------------------------
---------------ISG-G---LGS-----------------------------GS---
---GFGL------------------------SSGFGSG--SGSGFGF--G-GS-------
----VSGSSSSKIISTTTLNKRR-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------MSVHFSSRSTAFPSR----GAQV-HLSSG----RRGG-----
----------------------------------------------FG--S-SSLYGLG-
------------AS-RPSVAV--RS-----------------------------------
---------------AYA------------------------------------------
----------------R-------P-----VGAGI------REITINQSLLAPL----RV
DIDPSIQQ--VRQEEREQIKTLNDKFASF------IDK--VR------------------
----FLEQQNK-LLETKWALLQEQKSA-----KGSRL--PGVFE-AQIAGLRGQLEALQV
DGGRLEVELQS-MQDVVDDFKNK-YEDEINCRTA---AENEFVVLK--K---DVDAAYMN
KVELEAKVDALNDEINFLKTLNET-----ELTELQSQISDT----SVVLSMDNSRSLDLD
GIIA-EVRAQYEEIAN-RSRAEAEAWYQSK--FETLQAQAGKHGDDLRNTQKEIAEMN--
RAIHRLQAE-I--DNIKN------------------------------------------
-----Q-RA--KLEAAIAEAEE-HGELAL-EDARAKQ----QELEAALRQTKQDMARQLR
EYQELMNVKMALDIEIATYRKLLEGEE--------------------------Q-RLT-G
DGVGA---V--------NIST---------------------------------------
-----------------TIG----------------GSSTLTFGG-----TMGTNALSFS
SS-----AGPRA------------------------------------------------
--------LQAYSIRTPSIGHKSVRN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------M--
----NRQVCKT--S--GGGSQGFTGRSAVVSG------SSR-M-SS---VARSGGA-S--
-----GG-------------------------ACGFR----GG---AGGFGSRSLYSLGG
N-KSISISVAG-GS-RAGGFGGGRS------SSGSVFGGGYGGGFGGGR-----------
-----GIGGGFGGAGGFGGGAGGFGGGAGGFGGA-----GGFGGPRGFGGPGGFG-----
--PGGFGGPG--GFGP---GGFGGP-GG--FPGGI------QEVTVNQSLLQPL----NV
EIDPQIGQ--VKTQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWELLQQQTTGAG--SGPNNL--EPFFE-SYISFLRRQLDLALG
ERGNLEGELKN-MQDLVEDFKKK-YEDEINKRNA---AENEFVGLK--K---DVDAAYMT
KTELQAKVDSLTDELNFLRTLYEM-----------SHVSDT----SVVLSMDNNRCLDLD
SIIA-EVKAQYEEIAQ-RSKAEAEALYQTK--LGELQTTAGRHGDDLKNTKSEIMELN--
RMIQRLRAE-I--ENVKK------------------------------------------
-----Q-NA--NLQAAIAEAEQ-RGEMAL-KDANAKL----QGLQTALQKAKDDLARLLK
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RMS-G
ECQCS---V--------VSNVTSTSSG---------------------------------
--------SGGSRGGFSGGSSG-------------GYRGGSTSRG---------S-----
-----------------SGGYG----GVRG---------SSSGGYQSGSS--GGYQSG--
SS----GGYQSGS----------SGN----------------RLSS-GGS--SSVSQSGI
GSSSG--GI-QTSGGSSYKS----GSGGSTNIRFS----QTT------------------
------------------------------------------------------------
----------SSS-QHCSK-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQSSVS--FR-SGGGHSFSAASAVTPS-----VTRT-SFSSM---SRSGG--GGG
GFGRVS--------------------------LG-------GAYGG-GGYGSRSLYNMGG
S-KRISMSSS----GG--SFRNR-------------FGGG--A----GGGYGFGSGA-G-
--------------SGFGFG--GGAGGG-------------------------F----GL
G--GGA-GFGG-GFGGPGFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPAIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVRQNL--EPLFE-QYINNLRRQLDGILG
ERGRLDSELRN-MQDLVEDFKNK-YEDEINKRTT---AENEFVMLK--K---DVDAAYMN
KVELEARVEALMDEINFLKVFFDA-----ELSQMQTHVSDT----SVVLSMDNNRNLDLD
SIIA-DVKAQYEEIAN-RSRTEAETWYQSK--YEELQQTAGRHGDDLRNTKHEISEMN--
RMIQRLRSE-I--DNVKK------------------------------------------
-----Q-CA--NLQNAIADAEQ-RGELAI-KDARNKL----AELEDALQKAKQDMARLLR
EYQELMNTKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VG-PV-------N-ISVVTSNV----------------------------------
------------SSGYGGGS-GGYGG----G---SGFGG--GLGGGLGSG----------
------------------------------------------LG-GGGSG----SYYS--
-----------------------SSSG-----GVGLG--GGLSVGG-------------S
GFSAS---SGRGMGGGFGS---GG-G-SSSSVKFV----STTS-S---------------
------------------------------------------------------------
-------------SRKSFKS----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

-----------------------------------------------------MNGVSWS
------------------------------------QGLQEGICLWFSPPASTPASTMSI
R--VTQKSYK--VST--SGPGAFSSRSFTSGPS-----ARL-S-----------------
-------------------------------------------------------SRVST
-----------------------S-----------SFRGG------------LGAGY---
--------------AG---A----------------------------------------
---------------S-----GL-------GMGGI------TAVTINQSLLNPI----KM
DVDPNIQA--VRT QEKEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQQ-QKT-----ARSNM--DNMFE-SYINNLRRQLETLGQ
EKLKLEAELGN-MQGLVEDFKNK-YEEEINKRTE---MENEFVLIK--K---DVDEAYMN
KVELESRLEGLTDEINFLRQLYEE-----EIRELQSQISDT----SVVLSMDNSRSLDMD
SIIA-EVKAQYEEIAN-RSRAEAESVYQIK--YEELQMLAGKHGDDLRRTKTEISEMN--
RNISRLQAE-I--EGLKG------------------------------------------
-----Q-RA--SLEAAIADAEQ-RGELAL-KDARAKQ----QELETALQRAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEES---------------------------RLE-S
---GM---Q--------NMSIHTKTTSG--------------------------------
---------------YAG---------------------GLSS-----------------
---AYG------------------------------GLTSPGLSYGLG------------
--------------------------------SS---------FGSGV---------GSS
SISRT-------------------SSTKAVVVKKI------ETRDGRLVSESSDILPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MIARQQSVR-----G-VSRGFSGGSAI-AGG----VKRV-AFSSAS---MSGGA----
-----------------------------------------GRCS-SGGFGSRSLYNLGG
H-KSISMSVAGSCQ-GG-GYGGAGG-----------FGVGGFG-----------------
-------------AG-FG----------------AGGFG---------------------
---GGFGG----SFN--GRGGPGFP-AC--PAGGI------QEVTINQSLLTPL----QV
EIDPEIQK--VRMA EREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQQQTTIT----SPRNL--DSFFE-TYINALRKHLDSLTN
DKGRLQSELKL-MQDSVEDFKAK-YEDEINKRTA---AENDFVVLK--K---DVDAAYMI
KVDLEAKVDSLKDEINFLRVLYEA-----ELSQMQTHVSDT----SVVLSMDNNRNLDLD
GIIA-EVRAQYEEIAQ-RSKAEVESWYQTK--VQQLQISADQQGDSLRTTKNEISELN--
RMIQRLRAE-I--ENIKK------------------------------------------
-----Q-CQ--TLQASVADAEQ-RGELAL-KDAYSKR----TELEAALQKAKEDLARLLR
DYQALMNVKLALDVEIATYRKLLEGEE--------------------------C-RMS-G
ECQSA---V--------SISVVGGSASIGG------------------------------
---------------SAGIG---GS---------------------------AGIGL---
---GLGS------------------------GFGSGSG--SGSGFGF--G-GG-------
----VYGSSGTKITSSTTVT--KRSQR---------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
-------------------------------MT------QRSL---VTIKSGGTRNF---
-------------------SASSASLLPGCRPG----FSSV-SVSQS----G--------
---------------------------------------KSFGGGIGGGFGTRSLHSFGG
N-KRISIGGGYRST-R-ASFGGAAC-----------------------------------
---------------GLGVS-------GIGYRVGG-------------------------
------------AYGGYGYGGGMAP-----GAGGI------HEVTVNQSLLTPL----HL
EIDPSLQR--VRK EEKEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWSLLQEHKTT-----RA-NL--EPMFE-AYITNLRRQLECLGG
ERGRLETELKS-MQDVVEDFKNK-YEEEIHRRTA---AENEFVVLK--K---DVDAAYMN
KVELEAKVEALMDEINFLRAFFEA-----ELAQLQAQISET----SVVLSMDNNRSLNLD
SIIA-EVKAQYEDIAN-RSRAEAESWYQTK--YEELQRSAGQRGDDLRTTKMEISELN--
RAMQRLRSE-I--DNLKK------------------------------------------
-----Q-CA--TLQASIADAEQ-RGELAL-KDAKNKL----AELEDALQKAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEE--------------------------C-RLT-G
EGVGA---V--------NISVVSSSGGTGYSGGG--------------------------
-G----LC-VSGG-GYS-------------------GGGYSGSGLCYGGGG----SGGFS
STSGR-SVSGSS------------------------------------------------
--------SSMRIVSKTSSTKKSYRS----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MHRQVCKT--S--GGGSKGFSGRSAVVSG------SSR-M-SC---VARTGRT-G--
-----GG-------------------------VCGSR----GG---AGGFSSHSLYNLGG
N-KSICSSVAGGSRGGSFGFGGGFG------SCGGGFGGGR----------GVGGGFGG-
-------AGGFGGASGFG--------------GA-----GGFGGAGGFGGAGGFGGVGGF
GGVGGFG--------G---HGGFGP-GG--FPGGI------QEVTVNQSLLQPL----NV
EIDPQIGA--VRTQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQQQGTNSV--TGTNNL--NPIFE-SYISNLRSVLDRLQG
ERGNLEGELRN-MQEQVEDFKKK-YEDEINRRTG---AENEFVTLK--K---DVDTAYMN
KVELQARADSLMDEVNFLKTLYDA-----ELSQMQSHVSDT----SVILSMDNNRCLDLN
SIIV-EVQAQFEEITE-RNKAEITDLYQSK--LGELQTTAGRHGDDLKSTKSEIMELN--
RMIQRIRAE-I--ENVKK------------------------------------------
-----Q-NA--NLQTAIAEAEQ-RGELAL-KDAQAKL----QELQNALQKAKDDMARLLR
DYQELMNVKLALDIEIATYRKLLEGEE--------------------------C-RMS-G
EFQNP---V--------SISVVSSSSS---------------------------------
--------TSASAGGYGGG-FGLG------------GSGGG-------------------
-----------------------------R---------GSGSGFVSSGG-S-GFG----
------GGSGSGF-----------------------------GGGSGSGF--GGGSGSAF
G--GA--TT----LGGGSAM----ASALGGGPGTP-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
----------------------------------------------------------MR
S-SVSRQTYST--------KGGFSSNSASGG---GGSRIRT-SYSSVT-MSRSSGS--G-
--------------------------G---GV---------RSCPGSGGFGSRSLYNLGG
--KNISVSVAGGTSSG-RAL----------------------------------------
--------------GGFG--------------------TGAYL-----------------
-------GLG-------AGRQTFGP-VC--PPGGI------QEVTVNQSLLTPL----NV
EIDPEIQR--VRTQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQSQNTG--VTR-NL--EPLFE-TYLSNLRRQLDAKQS
EHGRLDMELRS-VQDNLEDFKNK-YEDEINKRTA---LENEFVLLK--K---DVDAAYMG
RMDLHGKVDTLTQEIDFLQHLFEM-----ELSQVQTHVSDT----NVVLSMDNNRSLDLD
SIIA-EVKAQYELIAQ-KSRAEAESWYQTK--YEELQVTAGKHGDSLRDTKNEIAELT--
RTIQRLQGE-V--DATKK------------------------------------------
-----Q-CQ--QLQTAIAEAEQ-RGEMAL-KDAKKKL----GDLDTALHQAKEDLARLLR
DYQSLMNVKLALDVEIATYRKLLESEE--------------------------S-RMS-G
ECPSA---V--------CISVTGNSTSVCA------------------------------
-----------------GG--------------AAGFGSGLSLGGA---GG--ANKGSFS
AN----------------------------------------VSYGT----------A--
KGGQVSG--GTSILRKT--TTVKTSSRRY-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTQKSYK--VS--TSGPRAFSSHSYMSGPS-----ACI-SSL---------------
---------------------------------------------------------MGS
-----------------------S-----------SFPGG------------LGG-----
---------------GYG------------------------------------------
-----------------GASG----------MGGI------TAVMVNQSLLSSL----VL
EVHPNIQA--VRTQEKEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQQ-QKT-----ARSNM--DNKLQ-SYINNLRRQLETLGQ
EKLKLEAELGN-MQGLVEDFKNK-YEDEINKRTE---MENEFVLTK--K---DVDEAYMN
E--LESRLEGLTEEINFLRQLYAE-----EIRELQSQISDR----SVVLSMDNSRSQDRD
SIIA-EVKAQYEEIAN-RSQA----EL------RACTRS-DESCRACWEHGDDLCRT---
------KTE-I--SEITG------------------------------------------
-----T-------------SAA-AQRAGI-KYANAKL----SELEAALQRAKQDVLRQLR
EYQELMNVKLALDIEIATYRKLLEGKES---------------------------RLE-S
---GM---Q--------NMSIHTKTTSG--------------------------------
---------------YAG---------------------GLSS-----------------
---AYA------------------------------GLTSPGLSCGLG------------
---------------------------------S--------SFGSGA---------GSS
SFSRT-------------------SSSRAVVVKKI------ETSDRKLVSESSDSCPSE-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

----------------------------MK--NTANKRNYSFH-----------------
LRAMHHPGWGWQLN-QDAHKSHGPRALQPPVFSTAH--------TSP---PQVPSHRPSS
PTM-SRQSSVT--FQSG-SRRGFSTTSATTPA-----AGRS-RFSSVS-MARSAV--GSG
GPGRIS--------------------------SA------------GAGFGSRSLYNLGG
T-KRVSISGC-GSS-----FRSG-------------FGG--RA----SNGFGV-----S-
--------------SGFGYG--GGVGGGF-------------------------------
----------S-GFSGSSFP------VC--SPGGI------QEVTVNQSLLTPL----NL
QIDPTIQR--VRA EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQGSR----TVRQNL--EPLFD-SYISELRRQLESITT
ERGRLEAELRN-MQDVVEDFKVR-YEDEINRRTA---AENEFVALK--K---DVDAAYMS
KVELEAKVKSLPEEINFLHSVFDA-----ELSQMQTQVSDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEDIAN-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEISEMN--
RMIQRLRAE-I--DSVKK------------------------------------------
-----Q-CS--SLQTAIADAEQ-RGELAL-KDARAKL----VDLEEALQKAKQDMARLLH
EYQELMNIKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VS-PVNIS--------VVTSTV----------------------------------
------------SSGYGSGS--GIG-----------------------------------
---------------------------------------GGSLGLGGGSG----YSFTT-
-----------------------SG-------GHSLG--A--GLGG-------------S
GFSAT---SSRGLGG------------SGSSVKFV----ATTS-----------------
------------------------------------------------------------
------------SSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQSTVS--FR-SGGGRSFSTASAITPS-----VSRT-SFTSV---SRSGGG-GGG
GFGRVS--------------------------LG-------GAYGA-GGFGSRSLYNLGG
S-KRISISAS----GG--GFRNR-------------FGAG--A----GGGYGFGGGA-G-
--------------SGFGFG--GGAGG-------G-----------------GF----GL
G--GGA-GFGG-GFGGPGFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPTIQR--VRTEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWALLQEQGTK----TVRQNL--EPLLE-QYINNLRRQLDGIVG
ERGRLDSELRN-MQDLVEDFKNK-YEDEINKRTT---AENEFVMLK--K---DVDAAYMN
KVELEAKVDALMDEINFMKMFFDA-----ELSQMQTHVSDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEDIAN-RSRTEAESWYQTK--YEELQQTAGRHGDDLRNTKHEISEMN--
RMIQRLRSE-I--DNVKK------------------------------------------
-----Q-CA--NLQNAIADAEQ-RGELAL-KDARSKL----AELEDALQKAKQDMARLLR
EYQELMNTKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VG-PV-------N-ISVVTNTV----------------------------------
------------SSGYGGGS-G--------------FGS--GLGGGLGGG----L-----
-----GGGLGGGL--------------------------GSGLG-GGGSS----SFYSS-
------------------------SSG-----GVGLG--GGLSVGG-------------S
GFSAS---SGRSL--GFGS---GG-G-SSSSVKFV----STTS-S---------------
------------------------------------------------------------
-------------SRKSFKS----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MIARQSSVR-----G-ASRGFSSGSAI-AGG----VKRV-AFSSGS---MSGGA----
-----------------------------------------GRCS-SGGFGSRSLYNLGG
H-KSISMSVAGSCQ-GG-GYGGAGG-----------FGVGG-------------------
----------------YG----------------AGFGVGGFG-----------------
---GGFGG----SFN--GRGGPGFP-VC--PAGGI------QEVTINQSLLTPL----QV
EIDPEIQK--IRTA EREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQQQTTTT----SPKSL--DPFFE-TYINALRKNLDTLSN
DKGRLQSELKM-MQDSVEDFKTK-YEEEINKRTA---AENDFVVLK--K---DVDAAYMI
KVELEAKMESLKDEINFTRVLYEA-----ELAQMQTHVSDT----SVVLSMDNNRNLDLD
GIIA-EVRAQYEDIAR-KSKAEVESWYQIK--VQQLQMSADQHGDSLKTTKNEISELN--
RMIQRLRAE-I--ENIKK------------------------------------------
-----Q-SQ--TLQASVADAEQ-RGELAL-KDAYSKR----AELETALQKAKEDLARLLR
DYQALMNVKLALDVEIATYRKLLEGEE--------------------------C-RMS-G
ECKSA---V--------SISVVGGSASIGG------------------------------
------------------------S------------------------------GL---
---GLGS------------------------GFCSGSG--SGSGFGF--G-GG-------
----IYGGSGSKITSSATIT--KRSPR---------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MST
KTTIR---------SQN-SHRGFSAGSARVPG-----FNRS-GFSSVS-VCRSRGSG---
-----G-----------------------------S----GAMCG-GAGFGSRSLYGVGS
S-KRISIGGGSCGI-G-GGYGSQVG-----------------------------------
--------------G----------GVGSAIIFGG---------------------K---
-----------AGFGG-GCGSSGLP-VW--PPEDI------QEVTINQSLLTPL----NL
QIDPTIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
---CFLEQQNK-VLDTKWTLLQEQGTKT----VRHNI--EELFE-QYISTLRREQESING
DRGRLDSELRS-MQDTAEDYKNK-YEDEINKRTA---AENEFVTLK--K---EVEAVSMN
KTELQAKTDSLTDEINFRRDLYDA-----ELSQMQTRISDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEEIAQ-RSQAEAESWYQTK--YEELKVTGRRHGDDLRNTKQEITELD--
RKIQRLRTE-I--NNAKE------------------------------------------
-----Q-CA--KLQATILEAEL-RREMAL-KDARGKL----QGLEDATQKAKQDKVRMVK
GYQELMNVKMSLDMEIGTYRKLLEGEE--------------------------F-RLN-G
EG-VGP--V--------N---ISV-VQSTM------------------------------
------------SSGYGS----AGGA----SS----------------------------
---SLG--------------------------------------LGGGSS----YSYGSS
--HGLG-----------------------------------------------------G
GFSSG--SG-RGIS--GGLSSSGGSSST---IK-Y----SSN------------------
------------------------------------------------------------
----------SSS-RKSY-----------------RH-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MNRQVYKT--S--GGGSQGFSGRSAVVSG------SSR-M-SC---VARSGGA-S--
-----GG-------------------------ASGFR----GG---PGGFGSSSLYNLGG
N-KSISISVAAGGS-RTGGFGGGRS------ICG----GGYGGGLGGGYGGGFGGGFGGG
RG----VGGGFGGAGGFG--------------GA-----GGFGGAGGFGGPGSFGGPGGF
GP------------------------GG--FPGGI------QEVTVNQSLLQPL----NV
EIDPQIGQ--VKAQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWSLLQQQGTNSI--AGTNNL--EPLFE-NHINSLRSYLDSILG
ERGRLDSELRS-MQDLVEDFKRK-YEDEINKRTA---AENEFVTLK--K---DVDAAYMN
KVELQAKVDALMDETSFLRSIYDA-----ELSQMQSHVSDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEDIAQ-RSKAEAEALYQTK--LGELQTTAGRHGDDLRSTKSEIMELN--
RMIQRLRAE-I--ENVKK------------------------------------------
-----Q-NA--NLQAAIVEAEQ-RGELAL-KDANAKL----QDLQAALQQAKDDLARLLR
DYQELMNVKLALDVEIATYRKLLEGEE--------------------------CSRMS-G
ECQSA---V--------SISVVSSSST---------------------------------
--------TSASAGGY---------------------GGGLGG-----------------
--------------------GF----GVGG---------GAGSGFGRGGG-S-GFGGG--
S--------GF-----------------------------------------GGGSGFGS
GSGSG--GR-CGVSGGGFSS----GSNRGGSIKFS----SSS------------------
------------------------------------------------------------
----------QRC-SR--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQSSVS--FR-TGGSRSFSASSAITPS-----VSRT-SFSSV---SRSGG----G
GGGRIS--------------------------LG-------GA-CGAGGYGSRSLYNVGG
S-KRISYSSG----GG--SFRNQ-------------FGAGG---------FGFGGGA-G-
--------------SGFGFG--GGAG-S------------------------GF----GF
G--GGAGFG-G-GYGGAGFP------VC--PPGGI------QEVTINQNLLTPL----NL
QIDPTIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWALLQEQGTK----TIKQNL--DPLFE-QYINNLRRQLDGVLG
ERGRLDSELRN-MQDLVEDYKNK-YEDEINKRTT---AENEFVMLK--K---DVDAAYMN
KVELEARVDALMDEINFMKMFFDA-----ELSQMQTHVSDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEDIAN-RSRTEAESWYQTK--YEELQQTAGRHGDDLRNTKHEISEMN--
RMIQRLRSE-I--DNVKK------------------------------------------
-----Q-CA--NLQNAIAEAEQ-RGELAL-KDARNKL----TELEEALQKAKQDMARLLR
EYQELMNTKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VG-PV-------N-ISVVTNSV----------------------------------
------------SSGYGGGS-S---I----G---VGSGFGGALGSGLGSG----F-----
-----A----------------------------------------GGL-----GPRFT-
-----------------------RGGG-----GLGLG--SGLSVGG-------------S
GFSAG---SSQG-GMSFGS----GGG-SGSSVKFV----STTS-S---------------
------------------------------------------------------------
-------------SRRSFKS----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MNRQVCKK--SF-SGGSQGFSGRSAVIS-G-----SSR-M-SC---VARSGGA-G--
-----GG-------------------------ACGIR----SGA---GGFGSLSLYNLGG
N-KSISISVA-GGS-RAGGFGGGRS------SCE----SGYGGG----YGGGFGGGFGGG
--R--GIGGGFG-------------------------------GA------GGFGGVGGF
GGVGGFGGPG--GFGG---PGGFGS-GG--FPGGI------QEVTVNQSLLQPL----NV
EIDPQIGQ--VKAQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQQQTTGSG--SGPNNL--EPFFE-SYISFLRRQLDSAVG
ERGNLEGELKN-MQSLVEDFKKK-YEDEINKRTA---AENEFVGLK--K---DVDAAYMN
KVELQAKVDTLTDELNFLRTLYEM-----ELSQMQSHVSDT----SVVLSMDNNRCLDLD
SIIA-EVKAQYEEIAQ-RSKAEAEALYQTK--LGELQNTAGRHGDDLKSTKSEIMEL---
RMIQRLRAE-I--ESIKK------------------------------------------
-----Q-NA--NLQASIAEAEQ-RGEMAL-KDANAKL----EGLKAALQKAKDDLARLLR
EYQELMNVKLALDIEIATYRKLLEGEE--------------------------C-RMS-G
ECQSA---V--------SISVVSNVTST--------------------------------
---------SSSSGGSRGGGFSG--S----SS--GG---YRGSG----------------
---------------STSISRDS-SGGYRG---------GSSTSTSRGSS-GG---NR--
GISGDSSSYG--------------------SVSG------GS--TGGYSV-----SQSGT
GSNSG--GI-QPFGGSGYKS----GSGGNANIRFS----QTT------------------
------------------------------------------------------------
----------SSS-QHSSK-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSTKTTVR--SQT-SSHRGFSASSARVPR-----LNRS-GFSSVS-VSRSRGSGGSG
A-------------------------------VC-----------GGAGFGSRSLYGVGG
S-QRISIGGG----SC--GIGAG-------------YGG--RV----SGGFGYGGGA-G-
--------------SGFGFG--GG--A------GG-----------------AF----GF
G--GG-AGFGG-GYGGAGFP------VC--PPGGI------QEVTINQNLLTPL----NL
QIDPTIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVRQNL--EPLFE-QYISNLRRQLDGILG
ERGRLDSELRN-MQDLVEDFKNN-TQLNVSK--------NSFTHVN--H---HWDASYST
I-ELHSQS---YKNIAESGSSVPQ-----ELSQLQTHVSDT----SVILSMDNNRSLDLD
SIIA-EVKAQYEEIAQ-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEIAEIN--
RMIQRLRSE-I--DHVKK------------------------------------------
-----Q-CA--NLQAAIADAEQ-RGEMAL-KDARSKL----EGLEDALQKAKQDMARLMK
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLN-G
EG--VG-PV-------N-ISVVQSTV----------------------------------
------------SSGYGGAS-------------------GA--G----------------
----------------------------------------SGFGLGGGSS----SYSYS-
-------------------------SG--------------HGLG--------------G
GFSSS---SGRGVG--SGLS--SAGGS-SSTVKYT----TTTS-----------------
------------------------------------------------------------
------------SSRKSYRH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQACKK--SF-SCGSQGFSGRSAVMSGG------SR-M-SC---VART----G--
-----GG-------------------------ACGFR----SG---AGGFGSHSLYNLGG
H-KSTSISVAAGGT-RAGGFSGGRS------SCGGGFRAGYGGSFGGSRG----------
------MGS-------------------------------------------GFGGAGSF
GGAG--------GFSG---FAGF---------GGI------QEVTVNQSLLQPL----NV
EIDPQIGQ--VKA QEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWELLQQHTVGSG--SAPRSL--EPFFE-SYISFLHKQLDSLLG
ERGNLEGELKN-MQDLVEDFKKK-YEDEVNKRTV---AENEFVGLK--K---NVDATYMN
KVELQAKVDSLTDEVNFLRTLYDM-----ELSQVQSHVSDT----SVVLSMDNNRDLDLD
SIIA-EVRAQYEEIAQ-RSKAEAEALYQTK--LGELQTTAGRHGDDLRSTKSEIMELN--
RMVQRLRAE-I--ENVKK------------------------------------------
-----Q-NA--NLQTSITEAEQ-RGEMAF-KDANAKL----QDLQAALQKAKDDLARTLR
DYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-REL-G
SLFAAS--S--------PAAVLNNVTC---------------------------------
--------TSSSSGSSLGAFRGVNGS----GS--SSS---SGSRG---------------
----------------SSGNSY------------------------REGS--SGSGSE--
GR---------G------------SNRVHQSPSS------GNRLGSGGST--SV-SQSGI
GFSSG--VT-QNSVGSGYKS----GNGGSVGVRFS----QTT------------------
------------------------------------------------------------
----------TSS-QQCSK-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--M-SRQSSIT--FQSG-SRRGFSTTSAITPA-----AGRS-RFSSVS-VARSAA--GSG
GLGRIS--------------------------SA------------GASFGSRSLYNLGG
A-KRVSISGC-GSS-----FRSG-------------FGG--RA----SNGFGV-----N-
--------------SGFGYG--GGVGGGF-------------------------------
--------------SGPSFP------VC--PPGGI------QEVTVNQSLLTPL----HL
QIDPTIQR--VRA EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQGSR----TVRQNL--EPLFD-SYTSELRRQLESITT
ERGRLEAELRN-MQDVVEDFKVR-YEDEINKRTA---AENEFVALK--K---DVDAAYMN
KVELEAKVKSLPEEINFVHSVFDA-----ELSQLQTQVGDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEDIAN-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEISEVN--
RMIQRLRAE-I--DSVKK------------------------------------------
-----Q-CS--SLQTAIADAEQ-RGELAL-KDARAKL----VDLEEALQKAKQDMARLLR
EYQELMNIKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VS-PVNIS--------VVTSTL----------------------------------
------------SSGYGRGS--SIG-----------------------------------
---------------------------------------GGNLGLGGGSG----YSFTT-
-----------------------SG-------GHSLG--A--GLGG-------------S
GFSAT---SNRGLGG------------SGSSVKFV----STTS-----------------
------------------------------------------------------------
------------SSQKSYMH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--ATQKSHR--VS--TSGPRAFSSHFYTSGPG-----ACI-SSSSF-------------
-------------------------------------------------------SRVGS
-----------------------S-----------SFRGG------------LGG-----
---------------GYS------------------------------------------
-----------------GASG----------IGGI------TTVTVNQSLLSPL----NL
E------A--VDT QKKEQIKTLNNKFASF------IYK--VQ------------------
----FLEQQNK-MLETKWSLLQQ-QKT-----AQSNM--DNIFQ-SYINNLRQQLETLGQ
EKLKLEAELGN-MQGLVEDFKNK-YEDEINKRTE---MENEFVLIK--K---DVDE----
-VELESRLEGLTDEINFLRQLYEE-----DIPELQSQISDT----SVVLPMDNSHSLDMD
SIIS-EYEITN------RSR-------------VELQTLAGKHGDDLQHTKTEISAMN--
RNISWLQAE-I--EGLKG------------------------------------------
-----Q-RA--SLEAAIADAEQ-RGELAI-KDANAKL----SELEAALQQAKQDM-----
-YQELMNDKLAVDIEIATYRQLLEGEES---------------------------WLE-S
---GM---Q--------SMSIHTKTTSS--------------------------------
---------------YAG---------------------GLSS-----------------
---VYG------------------------------GLTSPGLSCGLG------------
---------------------------------S--------SFGSGV---------GSS
SFSCT-------------------SYTRAVVVKKI------ETRDGTLVSEFSDVLPKW-
--TATAA--PP----SLPLLWLHQS----P------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTQKSSR--VST--SGPGAFSSRSFTSGPS-----ACS-SSSSF-------------
-------------------------------------------------------SRVSS
-----------------------T-----------GFRGG------------LGAGY---
--------------AG---A----------------------------------------
---------------S-----G------------I------TAVTVNQSLLNPI----KP
DMDPNIQA--VRT QEKEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQQ-QKT-----ARSNM--DNMFE-SYMNNLRRQLETLGQ
EKLKLEAELGS-MQGLVEDFKNR-YEDEINKRTE---MENEFILIK--K---DVDEAYMN
KVELESRLEGLTDEINFLRQLHEE-----EIRELQSQISDT----SVVLSMDNSRSLDMD
SIIA-EVKAQYEEIAN-RSQAEAENVYQIK--YEELQKLAGKHGDDLRRTKTEISKMN--
WNISRLQAE-I--EVHKG------------------------------------------
-----Q-RA--SLEATIIDAEH-RGEQAL-KDARTKQ----QQLEEALQKAKQDMARQLR
DYQELMNVKLALDIEIATYRKLLEGEES---------------------------RLE-S
---GM---Q--------NMSIRTKTTSG--------------------------------
---------------YAG---------------------GLSS-----------------
---AYG------------------------------GLTSPGLSYGLG------------
--------------------------------SS---------FGSGA---------GS-
TFSRT-------------------SSTKAVVVKEI------ETRDGRLVSESSDVLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MIARQQYVR-----G-GPRGFSCGSAI-VGG----VKKA-AFSSAS---MSGGA----
-----------------------------------------GRCS-SGGFGSRSLYNLGG
N-KSISISMAGCRQ-GA-GFGA--------------------------------------
-------AGGFGAAGGFG----------------SGFGAGGFG-----------------
---SGFGG----SFG--GRGGAGFP-VC--PAGGI------QEVTINQSLLTPL----HV
EIDPEIQK--VRTEEREQIKLLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWKLLQQQTTTT----SVKNL--EPFFE-AYINALRKQVDSLAN
DKGRLQSELKI-MQDSVEDYKTK-YEDEINKRAA---AENDFVVLK--K---DVDAAYMN
KVELEAKVDALNDEINFLRVLYAA-----ELSQMQTQVSDT----SVVLSMDNNRNLDLD
SIIA-EVRAQYEEIAQ-RSKAEAEALYQIK--VQQLQTSVDQHGDSLRNTKNEISELN--
RLIQRLRAE-I--ENVKK------------------------------------------
-----Q-CQ--TLQGSVADAEQ-RGEVAL-KDAYSKR----TELEAALQKAKEELARVLR
EYQELMSVKLALDIEIATYRKLLEGEE--------------------------C-RMS-G
ECQSA---V--------SISVVGGAASAGG------------------------------
---------------LG-GA---LGG----S---SGFG--LGSGSCAVG---LGGGL---
---GGSS------------------------GFGLGSG--SGSGFGF--G-GG-------
----IGGSSSGKIISTTTVSKKS--FR---------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MNRQVCKK--SF-SGGSQGFSGRSAVVS-G-----SSR-M-SC---VARSGGA-G--
-----GG-------------------------ACGFR----SGA---GGFGSRSLYNLGG
N-KSISISMAAGSS-RAGGFGEGRS------SCG--FAGGYGGG----FGGSYGGGFGGA
--P--HA-----------------------------------------------------
------------------------------------------------------------
-----------------QLKRL-TPFLPS------LMQ--VR------------------
----FLEQQNK-VLETKWELLQQQTTG----SGPSSL--EPCFE-SYISFLRKQLDSLLG
ERGNLEGELKS-LQDLVEDFKKK-YEDEINKRTA---AENEFVGLK--K---DVDAAFMN
KVELQAKVDSLTDEVSFLRTLYEMMIPWFELSQMQSHVSDT----SVVLSMDNNRCLDLD
SIIA-EVRAQYEEIAQ-RSKAEAEALYQTK--LGELQTTAGRHGDDLRNTKSEIIELN--
RMIQRLRAE-I--ENVKK------------------------------------------
-----Q-VG--------------------------------LDLQAALQKAKDDL-----
---ELMNVKLALDVEIATYRKLLEGEE--------------------------C-RMS-G
ECQSA---V--------CISVVSNITST--------------------------------
---------SGSSGSSRGVFGGVSGS----GS--GGYKGSSSSS----------------
--------------------SSS-YGVISG---------GSSSGYGGVSS-GS---TG--
GR-GSSGGCQ--------------------SSSS------GSRLSGAGSIS---VSHSGM
GSSSG--SV-YTSGGSGYKS----GGGGSTSIHFS----QTT------------------
------------------------------------------------------------
----------SSS-QHSSTK----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--M-SRQSTIT--FQTG-SRRGFSTSSATTPA-----ASRS-RFSSVS-VARSPG--GTG
GPGRIG--------------------------SA------------GVGFGSRSLYNLGG
P-KRVSISGC-GSS-----FRSG-------------FGS--RA----SNGFGV-----N-
--------------SGFSYG--GGIGGGF-------------------------------
--------------GGPGFP------VC--PPGGI------QEVTVNQSLLAPL----NL
QIDPAIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWSLLQEQGTR----SVRQNL--EPLFD-AYLSDLRRQLESITN
ERGRLEAELRN-TQDTVEDLKVR-YEDEINKRTA---AENEFVALK--K---DVDGAYMN
KVELEAKVKSLADELNFHRSVFEA-----ELSQMQTQVSDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEDIAN-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEISEMN--
RMIQRLRTE-I--DNVKK------------------------------------------
-----Q-CS--SLQTAIADAEQ-RGELAL-KDARAKL----VDLEEALQKAKQDMARLLR
EYQELMNVKLALDMEIATYRKLLEGEE--------------------------S-RLS-G
EG--VS-PVNIS--------VVTSTV----------------------------------
------------SSGYGGGS--GIG-----------------------------------
---------------------------------------GGSLGVGGGSG----YSFTT-
-----------------------SG-------GHSLG--A--GLGV-------------S
GFSAS---SSRGPGG------------SGSSVKFV----STTS-----------------
------------------------------------------------------------
------------SSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------PRA---PSGTSVRFRLLASTLASTMSI
R--VTQKSYK--VS--TSSPWAFSSRSYTSGPA------RI-SSSAF-------------
-------------------------------------------------------SRVGG
S---------------------GS-----------SFRGG------------LNS-----
------------------------------------------------------------
-----------------SMSVV--------GSYGS------PAISVNQSLLSPL----KL
EVDPNIQA--VRTQEKEQIKS-NNKFASF------IDK--VR------------------
----HLEQQNK-ILETKWGLLQE-QKI-----AGSNI--DNMFE-SYINNLRRQLDTPGQ
EKLKLEVELGN-LQG-VEDFKNK-YEDEIKLRGD---MENEFVLIK--K---DVDEAYMH
KIELESRLEGLTVEIKSSGQLYEE-----ETHELQSQISTR----PRCCPLATAAPWTLD
GVIA-EVKAQYEDIANNRSRAEAETMHQIK--YEELQTLAGKHGDDLRRTKTEISEMN--
RSISRLQAE-I--ETLKN------------------------------------------
-----Q-RA--ALEAAIADAQQ-CGELAV-KDANAKV----AEPEASLQRDKQVMARQLR
EYRELLSVRLALDIEIATDCKLLEGKKS---------------------------RLE-S
---GM---Q--------NMSIHTKTTSG--------------------------------
---------------YSG---------------------GLNL-----------------
---AYG------------------------------GLTSPGPNFGPG------------
-----------------------------------------------------------G
SFSRS-------------------SSSKAVVLKKI------ETQDGKLVSESSDVLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSR
QASYSQQSCR---SSGGGHRQGFSGHSAIVSSQSRISSTKS-S----L-ASRSGGGG---
-------------------------------------GGSAACAMMGGGFGSRSLYSLGG
N-KKISISVAGGST-RAG-G---FGGASGGYLRGSGFGGGGRGM-----GGGF--G----
-----------GRAGGFRGGAGGFGGGAG--GFGGGA--GGFGGGVG-----------GF
GG-------PG-GFG-----GPSGP-GG--FPGGI------QEVTVNQSLLQPL----NV
EIDPQIGQ--VKA QEREQIKTLNDKFASF------IDK--VR------------------
----FLEQQNK-VLETKWSLLQEQGSGSN--TNNRNL--ESFFE-NYISSLKAFLDGLHI
EKDKLQEELRS-MEEMVEDFKKK-YEEEINKRTA---AENDFVVLK--K---DIDAAYMT
KVELEAKVDSVTDEINFLKALYDA-----ELSQLQSDTSDT----SVVLSMDNNRDLDLD
SIIA-EVRAQYEAIAQ-RSKAEAEALYQTK--LGELETTAGRHGDDLKSTRSEISELN--
RLIQRLQAE-I--ESIKK------------------------------------------
-----QVGR--RRGLTSTVLEQ-RGEVAL-KDADTKL----QELKVALQQAKEDLARLLK
EYQELMNVKLALDVEIATYRTLLEGEE--------------------------S-HL---
------------------VQMVHNTSSSSS------------------------------
------------SGGGSGALGGG----------------------------AGGRGGAGG
RG-GLGSGGLGNGGLSSG-------------------------GLGRGGL-G----SGGR
SGGGLG---SG-----------DQSCGVS-RG------------GLGS---GAV----SS
GSSAG--RG-GLSTSGGIVSGGSSSSSSRSSVQIS----QSS------------------
------------------------------------------------------------
----------SQS-QRSHHKF---------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MST
R-V-TQKTYK--VST--SGPRAFSSRSYSSAPG-----TRI-SSSSF-------------
-------------------------------------------------------SRVGS
-----------------------------------IYRGG------------LGTSM---
--------------SL---A----------------------------------------
---------------GGYGG-AG-------GMGSI------TAVQVNQSLLSPL----KL
EVDPNIQA--VRNQEKEQIKTLNNKFASF------IDK--VW------------------
----SLEQQNK-ILETKWSLLQQ-QKT-----TRSNM--DNMFE-SYINNLRRQLDTLGQ
EKLRLEAEFGN-MQGLVEDLENK-YEDEINKRTE---MENEFVLIK--K---AVDEAYMN
KVELESRLEGLTDEINFYRQLYEE-----EIRELQSQISDT----SVVLSMD-NRSLDLD
GIIA-EVKAQYEDIAN-RSRAEAETMYQIK--YEELQTLAGKHRDDLRRTKTEISEMN--
RNISRIQAE-I--KGLKG------------------------------------------
-----Q-RA--SLEAAIADAEQ-RGELAI-KDAQSKM----AELEATLRNTKQDM-RQLR
EYQELMNVKLALDVEIATYRKLLEGEEN---------------------------LLE-S
---GM---Q--------SMSIHTKTTSG--------------------------------
---------------YSG--------------------GLMSP-----------------
---SYG-----------------------------------NLNYGLG--------FQ--
---------------------------------A--------NLGSGG---------SSG
SFSRT-------------------SSSKTVVVKKI------ETRDGKLVSESSDVLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSV
L--INKKSYRS-TS--STAPRSFSSLSYTAGPV-----GSTKISSSF-------------
-------------------------------------------------------SSYGG
-----------------------S-----------RFGAGS-----------FRGPS---
--------------MGYG------------------------------------------
---------------------AG-------AGGSI------TAVNVNQSLLAPL----NL
EIDPSIHH--VRTQEKEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWDLLQG-QKT-----TRSNI--NSLFE-AYISNLRRQLDGLGQ
EKMKLESELGN-MQGLVEDFKNKWYEDEINRRTE---KENEFVLLK--K---DVDEAYMN
KVELESRLESLTDEINFLRHLYDE-----ELRELQSQINDT----SVVLTIDNNRKLDLD
GIIA-EVRAQYEEVAN-KSRAEAENMYKIK--YEEIKEVAGKHGDDLRNTKTEINELN--
RMIHRLQSE-I--DALKG------------------------------------------
-----Q-RA--SLEAAIAEAEE-RGEMAV-KDAKAKL----AELEAALQRAKQDMARQLR
EYQELMTVKLALDIEIATYRKLLEGEES---------------------------RLD-S
---GM---Q--------KMSIQTT-KSS--------------------------------
---------------YSG---------------------GLGS-----------------
---AYS------------------------------SY----------------------
--------------------------------GG--------GYNSSY---------SSS
GYSMN----SPTLES-AAV-----SKSKTVVIKKI------ETRDGRLVSETSDILSN--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQSTVT--FKTG-SRRGFSAASATTPT-----AGRS-HFSSIS-MVRSSG--GHG
GLGRIS--------------------------GV------------GTGFGSRSLYNLNG
S-KRISISGS----NS--GFRSG-------------FSG--RT-----GGYGFGSSI-K-
--------------SGLSFG--AGVGGAY-------------------------------
--------------GGAGFP------AC--PPGGI------QEVTVNQSLLAPL----NL
QIDPTIQR--VRKEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGMK----TVKQDV--EPVFE-KYINNLRQYLDTLKN
GRGRIDSELRN-MENVVEDYKSK-FEDEINKRTA---AENEFVALK--K---DVDGAYMN
KMEMEAHVSSLTDEINFLQTLYEM-----ESSQMQTQISDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEDIAN-HSRAEAESWYQTK--YEEL-VTAGRHGDALRNTKHEIAEMN--
XXXXXXXXX-X--XXXXX------------------------------------------
-----X-CA--NLQTSIADAEQ-RGEMAL-KDARAKL----VDLEEALQKAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEE--------------------------C-RLS-G
EG--VA-PVNIS--------VVTSTV----------------------------------
------------SSGYGSGS--GVS-----------------------------------
---------------------------------------GTSLGLGGGTS----YSYTT-
-----------------------SG-------GHSLG--G--GLGS-------------T
SFSTS---SGRGLGGGFG-------GGSNSSVKFV----STT------------------
------------------------------------------------------------
------------SSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
----MQNLVT--QKS--SGSWAFSSCTYVSGPG-----VCI-SSLSC-------------
-------------------------------------------------------SRVGS
S----------------------------------SFRGG------------LGGGY---
--------------G---------------------------------------------
------------------GASG---------MGGI------IAIMVNQSLLSPL----NL
EVDPNIQA--VCT QEKEQIKTLNNKFASF------IDK--VW------------------
----FLEQQNK-VLETKWSLLQQ-QKM-----ARSNM--DSMLE-SYINNLRRQLETLGQ
EKLKLEAELGN-MQGLGEDFKNK-YEDEINKHTE---TENEFVLIK--K---DVDEAYMN
KAELESLLEGLTDEINFLRQLYEE-----EIRELQSQISDM----SMVLSMDYSCSLDMD
SIIP-EVKVQYEEIAN-CSRAEAESMYQIK--YEELQKLAGKHGDDLRRTKTEISEMN--
RNISWLQAE-T--EGLKG------------------------------------------
-----Q-RA--SLEAAITDAEQ-RGELAV-KDVNAKL----SELEAALQRAKQDMMGQLR
EYQELMNVGLTLDIEIATYRKLLEGEES---------------------------RLE-S
---GM---Q--------NVSIHTKTTSS--------------------------------
---------------NAG---------------------GLSS-----------------
---AYG------------------------------GLTSPGIIYRLG------------
---------------------------------S--------SFGSGA---------DSS
SFSRT-------------------SSTRAVVVKKI------ETHDGKLESESSDVLSK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
-------------------------------MT------QRSS---VTIKSGGTRNF---
-------------------SASSASLLPGCRPG----FSSV-SVSQS----G--------
---------------------------------------KSFGGGFGGGFGTRSLHSFGG
N-KRISIGGGYRSS-R-ASFGGAAC-----------------------------------
---------------GLGVS-------GIGYRVGG-------------------------
------------AYGGYGFGGGMAP-----GAGGI------HEVTVNQSLLTPL----HL
EIDPSLQR--VRK EEKEQIKSLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWSLLQEHKTT-----RT-NL--EPMFE-AYITNLRRQLECLGG
ERGRLETELKS-MQDVVEDFKNK-YEEEIHRRTT---AENEFVVLK--K---DVDAAYMN
KVELEAKVDALMDEINFLRAFYEA-----ELAQLQAQISET----SVVLSMDNNRSLDLN
SIIA-EVKAQYEDIAN-RSRAEAESWYQTK--YEELQRSAGQHGDDLRSTKMEISELN--
RAMQRLRSE-I--DNLKK------------------------------------------
-----Q-CA--TLQASIADAEQ-RGELAL-KDAKHKL----AELEEALQKAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEE--------------------------C-RLT-G
EGVGA---V--------NISVVSSSGGTGYSGGG--------------------------
-G----LC-MSGSS-YS-------------------GGGYSGSGLCYGGGG----SGSFS
STSGR-SMSGSS------------------------------------------------
--------SSMRIVSKTSSSKKSYRS----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTQKSYK--VST--SGPWAFSSRSYMSGPG-----VLI-SFSSL-------------
-------------------------------------------------------PRVGS
S----------------------------------SFRGG------------LDTGY---
--------------A---------------------------------------------
------------------GVSGM-------GMEGI------TAVTINQSLLNPL----NL
EVDPNIQ A--MSTH EKEQIKTL-NKFAPF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQQ-QEM-----ARSNM--DNMFE-SYINNLRRQLETLGQ
EKLKLEAELGN-MQGLAEDFKNK-YEDEINKRTE---MENEFVLIK--K---DVDEAYMN
KVELESRLEGLTDEINFLRQLYEE-----EIRELQSQISDM----SVVLSVDNSRSLDMD
SIIT-EMKAQYEEIAN-CSPAEAESIYQIK--YKELQMLAGKHGDDLRHMKTEISEMN--
QNISQLQAE-I--EGLKG------------------------------------------
-----Q-RA--SLEAAIADADQ-RGDLAL-KDACSKQ----QELETALQWAKQDMAWQLR
EYQELMNIKLALDIEITTYHKLLEGEES---------------------------RLE-S
---GM---Q--------NMSIHTKTTSG--------------------------------
---------------YAG---------------------GLSS-----------------
---AYG------------------------------GLTSPGLSYGLG------------
---------------------------------S--------SFGSAM---------GPS
SVSCT-------------------SSTKAVVVKTS------CPSEQL--QQLQQPLPACP
S-----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MTSKSTIR--TH--SSSRGYSASSARVPG-----AHRS-GFSSVS-VSRSRGSGGLG
G-------------------------------VC-----------GGAGFGSRSLYGLGA
S-KRISIGGG----SC--AISGG-------------YGG--RV----GGGFGFGGGA-G-
--------------SGFGFG--GG--A------GS-----------------GF----GL
G--GG-AGFGG-GYGGASFP------VC--PPGGI------QEVTINQNLLTPL----NL
QIDPTIQR--VRTEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWTLLQEQGTK----TVRQNL--EPLFE-QYISNLRRQLDSILG
ERGRLDSELRN-MQDVVEDFKNK-YEDEINKRTA---AENEFVTLK--K---DVDAAYMN
KVELQAKADSLTDEINFLRTIYDA-----ELSQMQTHISDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEEIAQ-RSRAEAESWYQSK--YEELQVTAGRHGDDLRNTKQEIAEIN--
RMIQRLRSE-I--DHVKK------------------------------------------
-----Q-CA--NLQSAIADAEQ-RGEMAI-KDARNKL----EGLEDALQKAKQDMARLLK
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------QIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWELLQQQGTGSR--SGTNNL--EPLFE-QYISSQRSYLDGILG
ERGRLESELRS-MQDLVEDFKKX-XXXXXXXXXX---XXXXXXXXX--X---DVDAAYMN
KVELQAKVDALTDEINFLRTLYDL-----ELSQMQSHVSDT----SVVLSMDNNRCLDLD
SIIA-EVRAQYEEIAQ-RSKAEAEALYQTK--LGELQSTAGRHGDDLKSTKSEIMELN--
RMIQRLRAE-I--ENVKK------------------------------------------
-----Q-NA--TLQAAIAEAEQ-RGELAL-KDANAKL----QELQAALQQAKDDLARLLR
DYQALMNVKLALDVEIATYRKLLEGEECS--------------------------RMS-G
EC--QS-SV-------S-I-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MTQRSSI---TIKSGGTRNFSASSASLLP----ASCRP-SFSSVS-MSQSGKS----
-----------------------------------------FGGGFGGGFGTRSLHSLGG
S-KRISIS---GGY-RSS-RSSFG----------------GASC-----G--LGVGGLG-
-------YRMGGGFGGYGMG----------------------------------------
----------------------GGM-MA--GAGGI------QEVTVNQSLLTPL----NL
EIDPSLQR--VRK EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWSLLQDH--KT----TRANI--EPMFE-AYINNLRRQLDCLGG
ERGRLEMELKN-MQDVVEDFKN------------------------------DVDAAYMN
KVELEAKVDALMDEINFLRAFYEA-----ELAQLQAQISET----SVVLSMDNNRSLDLD
SIIA-EVKAQYEDIAN-RSRAEAESWYQTK--YEELQRSAGRHGDDLRTTKMEISELN--
RAMQRLRSE-I--DNLKK------------------------------------------
-----Q-CA--SLQAAIADAEQ-RGEMAL-KDAKNKL----AELEDALQKAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEE--------------------------C-RLT-G
EG-VGS--V--------NISVVSSSGGSGY------------------------------
------------S-G-------GSGL----CMGGGGYNSCLSY------GGS--------
------------------------------------------------------------
--------------------------------------------------------GGGS
GFSST--SS-R--------GGS----SSSSSMRII----SKT------------------
------------------------------------------------------------
----------SSS-TKKSYRS---------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
H-------------F---SSPLFSSRSAGFSGR----GAQV-RLSSA----RPGG-----
----------------------------------------------FG-S--SSLYGLG-
------------AS-RPRVNM--RS-----------------------------------
---------------AYG------------------------------------------
----------------G-------P-----VGAGI------REVTINQSLLAPL----RL
DTDPSLQR--VRQ EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-LLETKWALLQEQKSA-----KSSRL--PDIFE-AQIAGLRGQLEALQV
DGGRLEVELRS-MQDVVEDFKNK-YEDEINRRTA---AENEFVVLK--K---DVDAAYMS
KVELEAKVVALNDEINFLRTLHET-----ELTELQSQISDT----SVVLSMDNSRSLDLD
GIIA-EVKAQYEEMAK-CSRAEAEAWYQTK--FETLQAQAGKHGDDLRNTRSEIAEMN--
RAIQRLQAE-I--DAIKN------------------------------------------
-----Q-RA--KLEAAIAEAEE-RGELAL-KDARAKQ----EELEAALQRAKQDMARQLR
EYQELMSVKLALDIEIATYRKLLEGEE--------------------------S-RLA-G
DGVGA---V--------NIS----------------------------------------
---VVNST-GGSG---SGSG----------------GGIGLSFGG-----TMGSNALSFS
SS-----AGPGA------------------------------------------------
--------LKAYSIRTTSTSRRSARN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
-QTVAQKSVG---TRSGGLAKGFSAASATM------PVNRS-SFSSMS-MSCSSGG----
-----------------------------------------GIGQISGGFGSRSLHNLGR
S-KRISVS---GGY-CSA-RP---------------------------------------
---------------GYSYG----------------------------------------
----------------------LGH-GC--GPGGI------QGVTVNQNLLAPL----NL
EIDTSMQR--VRQEEKDQIKSLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWSLLKDQ--KV----VKNNI--EPMFE-VYISNMRRQLEALAG
DRLQLSSELKA-MQDAVEDFKIR-YEEEINKRTT---AENDFMLLK--K---DADAAYMS
KVDLGTRVDALTDEINFLRALYEA-----ELSQMQSQISDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEDIAN-RSRAEAESWYQSK--YEELQLTAGQHGADLHNTKVEISEMK--
CVVQRLHSE-I--DSVRK------------------------------------------
-----Q-CA--SLQTAITDAEQ-HGEMAI-KDAKAKL----AELEDALQKAKADLARQLR
EYQELMNVKLALDIEIATYRKLLEGEE--------------------------C-RLA-G
EGVG-A--V--------NI-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSR
QVSYGQQSFR---TSGGGQRQGFSGRSAVVSSKSHISSGRS-T----S-ASRYGGGGG--
---------------------------------SGGGSASSACAAMGRGFGSRSLYSLGG
N-KKISISVAGGSY-QAG-G---VGGGRSCGLGGSGFGAGGMG-----------------
-------------------------GGA------GGA--GGF-GGPG-----------GF
GG-------PG-GFG-----GSGGP-GG--FPGGI------HEVTVNQSLLKPL----NV
EIDPQIGQ--VKTQEKEQIKTLNNKFAAF------IDK--VR------------------
----FLEQQNQ-VLETKWQLLQDQGSTSN--SNDRNL--EPFFE-NYISSLRAHLDMLVN
EKNKLTGELSS-MEDLVEDFKKK-YEDEINKRTA---AENDFVVLK--K---DVDAAYMT
KVELEAKVESVMDEINFLKALYDA-----ELSQMQSDTSDT----SVVLSMDNNRCLDLD
SIIA-EVRAQYEDIAQ-RSKAEAEALYQTK--LGELENTAGRHGDDLKSIKSEISELN--
RMIQRLRAE-I--ENVKK------------------------------------------
-----YNAN--LQA-AIADAEQ-RGEMAL-KDANAKM----VELKAALQQAKDELARLLR
DYQELMTVKLALDMEIATYRKLLEGEE--------------------------C-RMS-G
ECQN-T--V--------SIEMVHSSSSSSG------------------------------
------------G-----SMGGG----------------------------AGGHGRGGT
SGGTCGSGGTGGKGIGSGG------------------------SYGRGGT-G----RK--
---GMG---SG-----------SHGGSSS-GG------------GFSSGGSGSV----GG
GYSS-------QSGGSGVVSGG-----GSSSIQVS----QSS------------------
------------------------------------------------------------
----------TRS-QRSNSKF---------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTQKSYK--MP--TSDPRAFSSRSYTSGS------------LSF-------------
-------------------------------------------------------SGVDS
-----------------------S-----------SFRDG------------RGS-----
---------------SYG------------------------------------------
-----------------GASV----------MRGI------TTVAVNQSLLSPL----VL
EVDPNIQV--VSTQEKEQIKTLNNRFASF------IDK----------------------
--------QNK-MLETKWSLLLQ-QKT-----AGSNM--PNMFE--------------GQ
EKLKLEGELGN-MQGLVEDFKNK-YEDEINKRTE---MESEFVLIR--K---DVD-----
-------------EINFLGQLYEE-----EIQELQSQISDT----SVVLSMDNSRSLDMD
SIIA-EVKAQYEELAN-CS--------------------GAEQGDDLQRTETEISEMN--
LNISGLQAE-I--EGIKG------------------------------------------
-----Q-RA--SLEDAMADAEQ-RGELAI-KDANAKL----SELEAALQRAKQDTAWQLR
EYQELMNVKLALDIEIATCRKLLEGEES---------------------------RLE-S
---GM---Q--------NMYIHRKTTSS--------------------------------
---------------FAG---------------------GLSS-----------------
---AYG------------------------------GFTIPGLSYSPS------------
------------------------------------------------------------
----------------------------AVVVKKI------ETRDGKLVSESSDVLSK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MST
R--VTHKSYK--VST--SGPGAFSSRSLTSGPS-----ARL----SF-------------
-------------------------------------------------------SRVSS
S----------------------------------GFRGG------------LGAGY---
--------------F---------------------------------------------
------------------GASGI-------GMGGI------TAVTINQSLLNPI----KE
DVDPNIQA--VRT QEKEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQQ-QKT-----ARSNM--DNMFE-NYINNLRRQLETLGQ
EKLKLEAELGN-MQGLVEDFKNK-YEEEINKRTE---MENEFVLIK--K---DVDEAYMN
KVELESRLEGLTDEINFLRQLYEE-----EIRELQSQISDT----SVVLSMDNSRSLDMD
GIIA-EVKAQYEEIAN-RSRAEAESIYQIK--YEELQMLAGKHGDDLRRTKTEISEMN--
RNISLPLLR-L--PQSPG------------------------------------------
-----G-RL--LCRGAQGTGDP-P-------DAQP-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQACKK--SF-SCGSQGFSGRSAVVSG------SSR-S-SC---VARSGAA-S--
-----GG-------------------------ACGFR----GG---AGTFGSHSLYNLGG
S-KSISISV-------AGGFSGGRS------SCGSGFGSGYGGSFGSSRG----------
------MGG-------------------------------------------GFGGASGF
GGAG--------GFGR---PGGFGP-GG--CPGGI------QEVTINQSLLQPL----NV
EIDPQIGQ--VKA QEREQIKILNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWELLQQQTTRSG--SGPLNL--ESFFE-SYISCLRKQLDSLLG
AKGSLQGELKS-MQDLVEDFKRK-YEEEINRRTT---AENEFVALK--K---DVDGAYMS
KVELQAKVDSLTDEINFLRTLYDM-----ELSQMQSHISDT----SVVLSMDNNRCLDLD
SIIA-EVKAQYEDIAQ-RSKAEAEALYQTK--LGELQTTAGRHGDDLRSTKSEIMELN--
RTIQRLRAE-I--ENVKK------------------------------------------
-----Q-NT--NLQASIAEAEQ-RGERAL-KDADAKF----QDLQAALQKAKEDLARLLR
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EFQNA---V--------SISVVSNVTS---------------------------------
--------TS-S----SGGYRGAGGS----NY--G----GD-------------------
----------------SSGRSS------------------------SS------------
---------------------------IGSRGSS------GSRLGSGGSI--SV-SQQRT
SFNSG--GS-QTSVGSCYKS----GRGGTSSVHFS----QTT------------------
------------------------------------------------------------
----------SSS-QQRSK-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSS
KTTIR---------SQGSGHGGFSASSARVPG-----LSHS-GFSSGS-ICQARGNG---
-----S-----------------------------M----QTACG-GAGFGSKNLYSLAD
T-NRVSTGGGSCAT-G-GRHGSRAG-----------------------------------
--------------GDF--A----GGINCGLGFG--------------------------
------------------GGGCGFP-VC--PSSGI------QEVTVNQSLLTPL----NL
EIDPTLQQ--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTKT----VRQSL--EPLFE-QYINTLRRQLDIVLG
ERGRLDSELKG-MQDTVKDLKDK-YEGEVNRHTA---TENEFVTMK--K---NVDATHMN
EVELQYKANGLKDEVRFLTSIFDA-----ELSQMQAHISDT----SVVLSMDNNRNLDLS
SIIA-EVKAQYEEIAQ-RSRAEAESWYQTK--YEELRVIAGSHSDNLRNTKQEIADVN--
HMIQRMRSE-I--DQAKK------------------------------------------
-----Q-V-------CSNLQSQ-RGELAL-KDARQKL----EGLEHALQKAKQHRAKLLM
EYHDLLNIKLALDVEIATYRMLLEGEE--------------------------C-RLN-G
EG-PGP--V--------DV-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------G-MQDMVEDFKNK-YEDEINKRTA---AENEFVTLK--K---DVDAAYMN
KVELQAKVDALMDEINFTRAFYEA-----ELAQMQTHISDT----SVVLSMDNNRDLDLG
SIIA-EVKAQYEEIAQ-RSRTEAESWYQSK--YEELQVTAGRHGDDLRNTKQEIAEIN--
RMIQRLRSE-I--DHVKK------------------------------------------
-----Q-CA--NLQAAIADAEQ-RGELAL-KDAKSKL----VELEDALQKAKQDMARLLK
EYQELMNVKLALDVEIATYRKLLEGEECR---------------------------LS-G
EG--VG-PV-------N-ISVVQSTV----------------------------------
------------SSGYGSAGGV--------------------------------------
---------------------------------------GSGFGLGGGSG----YSYG--
-------------------------S--------------GHSLR--------------G
GFSSG---SGRGFG--GGLS--SAGG-S-STIKYS----TTSS-----------------
------------------------------------------------------------
------------TTRKGYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
----------------------------WGCAD-----SSR-M-SC---VACSGGA-G--
-----AG-------------------------VCGSR----GRA---GGFGSRSLYNLGG
N-KSISISVA--GS-WAGGFGGGRS------SCI----SGCGGG----YVGGYGGGICGV
--R--GMGSGYG-------------------------------G----------------
---------G--SFGG---PGSYGS-SV--CPGGI------QEVTINQSLLQPL----NV
EIDPQIGQ--VKA QEREQIKTLNDKFASF------IDK--VR------------------
----FLEQQSK-VLETKWDLLQQRTAGLGSSLGSRVL--EPLFE-SYINCLRRQLDSALA
EKGNLEGELRN-MQDLVEDFRKK-YEDEINKCTV---AENEFVGLK--K---DMDAAFMN
KVELQAKVDGLTDEINFLRTLYET-----ELTQMQNHLHDM----SVVLSMNNNRCLDLD
SIIN-EVKAQYKDIAQ-KSKAEAEALYKPK--LDELENKAGRHGEDLKSTKNEIMELN--
WMIPRLRAE-I--ENVKK------------------------------------------
-----Q-NA--NLQNAIADAEQ-RGELAL-KDANAKL----QELQAALQQAKDDLARLVC
DYQELMNIRLALDVEIATYCKLLERLG--------------------------Y------
RPRRL---L--------SLAVVSNVTST--------------------------------
---------GTSPGGGRGGFGGVTGG--------SGYRGGGGSRR---------------
----------------------EQWQLWRS--------------------------QR--
RQRRVSQACS---------------------------------------------DGSRG
SVNPS--SV-QSSGSAGYKS----GSGRGTTICFT----QTT------------------
------------------------------------------------------------
----------SSN-QLCK------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MIARQQCVR-----G-GPRGFSCGSAI-VGG----VRKA-AFSSAS---ISGGA----
-----------------------------------------GRCS-SGGFGSRSLYNLGG
N-KSISISMAGGRQ-GA-GFGAAGG---------------F-G-----------------
------AAGGFGAAGGFG----------------SGFGAGGFG-----------------
---GGFGG----SFG--GRGGAGFP-VC--PAGGI------QEVTINQSLLTPL----HV
EIDPEIQK--VRT EEREQIKLLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWKLLQQQTTTT----SVKNL--EPFFE-AYLNALRKQVDTLAN
DKGRLQSELKI-MQDSVEDYKTK-YEDEINKRTA---AENDFVVLK--K---DVDAAYMS
KVELEAKVDALNDEINFLRILYAA-----ELSQMQTQVSDT----SVVLSMDNNRNLDLD
SIIA-EVRAQYEEIAQ-RSKAEAEALYQTK--VQQLQTSVDQHGDSLRNTKNEISELN--
RLIQRLRAE-I--ENVKK------------------------------------------
-----Q-CQ--TLQGSVADAEQ-RGEVAL-KDAYSKR----TELEAALQKAKEELARVLR
EYQELMSVKLALDIEIATYRKLLEGEE--------------------------C-RMS-G
ECQSA---V--------SISVVGGAASAGG------------------------------
---------------LG-GG---LGG----S---SGFG--LGSVSCAGG---LGGGL---
---GGSS------------------------GFGLGSG--SGSGFGF--G-GG-------
----ISGSSSGKIISTTTLSKKS--FR---------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--M-SRQSSIT--FQSG-SRRGFSTTSATTPA-----TGRS-RFSSVS-VARSAA--GSG
GLGRIS--------------------------SA------------GAGFGSRSLYNLGG
A-KRVSISGC-GSS-----FRSG-------------FGG--RA----SSGFGV-----N-
--------------SGFGYG--GGVGGGF-------------------------------
--------------SGPSFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPTIQR--VRA EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQGSR----TVRQNL--EPLFD-SYISELRRQLESLTT
ERGRLEAELRN-MQDVVEDFKVR-YEDEINKRTA---AENEFVALK--K---DVDAAYMN
KVELEAKVKSLPEEINFLHSVFDA-----ELSQLQTQVSDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEDIAN-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEISEMN--
RMIQRLRAE-I--DSVKK------------------------------------------
-----Q-CS--SLQTAIADAEQ-RGELAL-KDARAKL----VDLEEALQKAKQDMARLLR
EYQELMNTKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VS-PVNIS--------VVSSTL----------------------------------
------------SSGYGSGS--GIG-----------------------------------
---------------------------------------GGSLGLGGGSG----YSFTT-
-----------------------SG-------GHSLG--A--GLGG-------------S
GFSAT---SNRGLGG------------SGSSVKFV----STTS-----------------
------------------------------------------------------------
------------SSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSSKS--------TMTRRGFSTSSARVPG-----TCRS-GFSSIS-VSRSRGSGGLG
G-------------------------------AC-----------GGAGFGSRSLYGLGG
P-QRISIGGS----SC--TTRSG-------------YGG--RL----GGGFGFGGAA-G-
--------------SGFGFG--SG--A------GG-----------------GF----GL
G--GG-AGLGG-GYGGSGFP------VC--PPGGI------QEVTINQSLLTPL----NL
QIDPTIQR--VKTEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVKQNL--EPLFE-QYINNLRRQLDSILG
ERGRLDSELRN-MQDLVEDFKNK-YEDEINKRTA---AENEFVTLK--K---DVDAAYMN
KVELQAKVDGLTDEINFLRAFYDA-----ELSQMQTHISDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEEIAQ-RSRAEAEAWYQTK--YEELQVSAGRHGDDLRNTKQEISELN--
RMIQRLRSE-I--DHVKK------------------------------------------
-----Q-CA--NLQAAIADAEQ-RGEMAL-KDARNKL----SELEDALQKAKQDLARLLR
DYQELMNVKLSLDVEIATYRKLLEGEE--------------------------C-RLN-G
EG--VG-QV-------S-ISVTQSNV----------------------------------
------------STGYGS--------------------------AGV-------------
---------------------------------------GGGLGLGGGSG----YS----
-----------------------YGG------GHSFG--G--------------------
GFSAG---SGRGVA--GGLS--SSGGS-SSTIKYT----TTS--S---------------
------------------------------------------------------------
------------SSRKSFKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSR
QSSVS---------FRSGGSRSFSAASAITPG-----ISRT-SFSSVSRS--GGGGGG--
-FGXXX-----------------------------X----XXXXX-XXXXXXXXXXXXXX
X-XXXXXXXXXXXX-X-XXXXX--X-----------------------------------
--------------XXXXXX----XXXXXXXXXXXXX-------------------XXXX
XX--------XXXXXX-XXXXXXXX-XX--XXXXX------XXXXXXXXXXXXXXXXXXX
XXXXXXXX--XXXXXXXXXXXXXXXXXXX------XXX--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTKT----IRQNL--DPLFE-QYINNLRRQLDSILG
ERGRLDAELRN-MQDLVEDFKNK-YEDEINKRTT---AENEFVMLK--K---DVDAAYMN
KVELEAKADALMDEINFLKIFFEA-----ELSQMQTHISDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEDIAN-RSRTEAESWYQTK--YEELQQTAGRHGDDLRNTKHEISEMN--
RMIQRLRAE-I--DNVKK------------------------------------------
-----Q-CA--NLQSAIAEAEQ-RGELAL-KDARNKL----AELEDALQKAKQDMARLLK
EYQELMNTKLALDVEIATYRKLLEGEE--------------------------C-RLT-G
EG-VGP--V--------NISVVTN-S---I------------------------------
------------SSAYGG----G-GG-----LGG-------------------GFG----
---GS---------------------------------------VGGPFG-GALSGGLTS
GLGASS-----------------------------------------------------G
GYYSS--SS-GGIGLSGGLGTGGSGFSAGSGRG---------------------------
------------------------------------------------------------
----------TGV-GFGTGGGSSSSVKFVSTTSSTRKSFK-------S------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MST
H-------------F---SSQVFSSPSAAFPGR----GAQV-RLSSV----RTGG-----
----------------------------------------------------SSLYGLG-
------------AS-RPRVAI--HS-----------------------------------
---------------AYG------------------------------------------
----------------G-------P-----VGAGI------HQVTINQSLLAPL----QV
DIDPSIQQ--VRQEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-LLETKWALLQEQKSA-----KSSSL--PGIFE-AHIAGLRKQLEALQL
DGSRLEVELRS-TQDVLEDFKNK-YEEEINRRTA---AENEFVVLK--K---DVDNAYMN
KVELEAKVNALNDEINFFRTFYEM-----XXXXXXXXXXXX----XXXXXXXXXXXXXXX
XXXX-XXXXXXXXXXX-XXXXXXXXXXXXX--FETLQAQAGKHGDDLRNTRNEIAEMN--
RAIQRLQAE-I--DNIKN------------------------------------------
-----Q-RA--KLESAIAEAEE-HGELAL-KDARAKQ----EELEAALQRAKQDMARQLR
EYQELLNIKLALDIEIATYRKLLEGEE--------------------------S-RLD-G
NGVGA---L--------NISV---------------------------------------
----VNT----------TGG----------------GGGGLTFGG-----TMGSNALKFS
SS-----GGPGT------------------------------------------------
--------LKAYSIRTTSATRRSTLN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------MGGI------TAVTINQSLLNPI----KV
DVDPNIQA--VRT QEKEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQQ-QKT-----ARSNR--DNMFE-NYINNLRRQLETLGQ
EKLKLEAELGN-MQGLVEDFKNK-YEEDINKHTE---MENEFVLIK--K---DVDKAYMN
KVELESRLEGLTDEINFLRQLYEE-----EIWELQSQISHT----SVVLSMDNSRSLDMD
GIIA-EVKAQYEEIAN-RSWAEAESVYQIK--YEELQRLAGKHGDDLRRTKTEISKMN--
WNISRLQAE-I--EGLKG------------------------------------------
-----Q-RA--SLEAAIRNAED-RGERAL-KDVHTKQ----QELESALQRAKQDMAKQLR
EYQELMNVKLALDIEIATYRKLLEGEES---------------------------RLE-S
---GM---Q--------NMSIHTKTTSG--------------------------------
---------------YAG---------------------GLSS-----------------
---AYG------------------------------GLTSPGLSYGLS------------
--------------------------------SS---------FGFGT---------GSS
SFS-----------------------HKAVVVKKI------ETRDGRLVSESSDVLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
----------------------------------------------------------MR
-SSMSRQTYST--------KGGFSSNSASGG---SGSRTRT-SFSSVT-MSRSSGSGGG-
--------------------------A--------------RCQPSMGGFGSRSLYNLGG
S-KTISASVAGGACSG-RAL----------------------------------------
--------------GGFGLS------------------GGAYM-----------------
-------GLG-------AGRQTFGP-TC--PPGGI------QEVTVNQNLLTPL----NV
EIDPEIQR--VRTQEREQIKALNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQGQNTG--VTRNNL--EPLFE-SYMSNLRRKLDGIQS
ERGRLDSELRN-VQDLLEDFKNR-YEDEINKRTA---AENEFVVLK--K---DVDAAYMC
QMDLQGKVNALTEEICFLQNLYEM-----ELSQVQTHVSDT----NVVLSMDNNRNLDLD
SIIA-EVKAQYELIAQ-RSRAEAESWYQTK--YEELQVTAGKHGDNLRDTKNEIAELT--
RTVQRLQGE-V--DAAKK------------------------------------------
-----Q-CQ--QLQTAITEAEQ-RGELAL-KDAQKKL----GDLDVALHQAKEDLARLLR
DYQALMNVKLALDVEIATYRTLLEGEE--------------------------S-RMS-G
ECQST---V--------SISVTGNSTTVSG------------------------------
-----------------GC--------------SSGTRGGLSLGVG---GG--GIKGGFS
TN----------------------------------------VGYSS----------A--
KGGAISG--GTSVLRKT--TTVKTSSRRY-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSV
R--VTQKSYK--MST--SGPRGFSSRSYTSGPA-----TRI-SSSSF-------------
-------------------------------------------------------SRVGS
S----------------------G-----------SFRGG------------LGAGL---
--------------GL---G----------------------------------------
---------------LG--GGYT-------GAGGI------TAVTVNQSLLSPL----KL
EVDPNIQA--VRT QEKEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQQ-QKT-----ARSNM--DNMFE-SYINNLRRQLDTLGQ
EKLKLEAELGN-MQGLVEDFKNK-YEDEINKRTE---MENEFVLIK--K---DVDEAYMN
KVELESRLEGLTDEINFLRQLYEE-----EIRELQSQISDT----SVVLSMDNSRSLDMD
GIIA-EVRAQYEEIAN-RSRAEAESMYQTK--YEELQTLAGKHGDDLRRTKTEISEMN--
RNISRLQAE-I--EGLKG------------------------------------------
-----Q-RA--SLEAAIADAEQ-RGEMAV-KDANNKL----AELEAALQRSKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEES---------------------------RLE-S
---GM---Q--------NMSIHTKTTSG--------------------------------
---------------YAG---------------------GLSS-----------------
---PYG------------------------------S----GLSYG--------------
--------------------------------FG---------FGSGG---------GSS
TFSRT-------------------SSSRAVVVKKI------ETRDGKLVSESSDVLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQTYS---TRAGGGGRSYSAASAIVPG-----GSRA-GFSSVS-VARSGGGGG--
G-----------------------------FGX------GGGGGGSGGGFGSRSLYSLGG
S-KRISFGV-GSSF-RSA-FGGGGSGLGGGSGGGFGLGGGGGGG-----GLGLGLGGGGG
GGGLGLGLGGGGGGGGLGLGLGGGGGGGGGYGFGGGPGGLGFGG----------------
--AGGMGGL-G-GLGG-GRGPVGF--GGPPGMGTI------QEVTINQSLLAPL----NL
EIDPNIQQ--VRKEEKEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWTLLQDQGQKNS--SGKNNL--DPLFE-AYINNLKRQLANLLS
ERGRMDGELKN-MQDLVEDFKNK-YEEEINRRTA---AENEFVVLK--K---DVDAAYMN
KVELEAKVDALTDELNFLRALYEA-----ELAQLSTQASDT----AVILSMDNNRDLDLS
SIIA-EVKAQYEDIAN-RSRAEAEAWYQTK--YEELQATAGKHGDDLRNTKGEISELN--
RLIQRIRAE-I--ENTRN------------------------------------------
-----Q-CA--TLQTAIGDSEE-RGELAL-KDAKAKM----MELEDALQKAKADMARQLR
EYQELMNVKLALDIEIATYRKLLEGEE--------------------------S-RLS-G
EGLN-P--I--------GYSVISSSSGTAG------------------------------
------------G---GGGF---GGL----SL--------SGG------GGGSGYGLGGG
GGSGFGLGGGSGSGYGLGGGGGSGYGLGGGGGSGYSLGGGGGSGYSLGGG-GGGYSFGSG
GGLGLG---GG-----------GGLGGGY-GGGS------GLGLGGGSSGSGLSSAG--G
NFSS--------------GSAK----GTNPGVKIV----SK-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
----MNRTLS---TRAGGAGRSYSAASAIVPG-----SGRA-GFSSAS-AARSGGAGG--
G-----------------------------FGRLGGGGGG---SGGGAGFGSRSLYNLGG
S-KRISIGV-GSSF-RAA-FGGGAAGGSGLGGGGGGAGCGAAGG-----GLGLGLGAGGG
G------FGGGGAGGGLGLGLGA---GGGGFGFGGGAGGLGFGGGHG--G----GGGFGF
GGLGGLGGFPA-GLGG-GRSPGGFP-GGPSGVGTI------QEVTVNQSLLAPL----NL
EIDPNIQQ--VRKDEKEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWTLLQEQGQKNN--SGKSNL--DPLFE-AYINNLRRQLANLLN
ERGRMDGELKN-MQDLVEDFKNK-YEEEINRRTA---AENEFVVLK--K---DVDAAYMN
KVELEAKVDALSDELNFLRALYEA-----ELAQLSAQVSDT----AVILSMDNNRDLDLS
SIIA-EVKAQYEDIAN-RSRAEAEAWYQTK--FEELQATAGKHGDDLRNTKGEISELN--
RLIQRIRSE-I--ENTRN------------------------------------------
-----Q-CA--TLQTAIGDSEE-RGELAL-KDAKAKM----IDLEDALQKAKADMARQLR
EYQELMNVKLALDIEIATYRKLLEGEE--------------------------S-RLS-G
QGLN-P--I--------SYSVISSSSGMAG------------------------------
------------GAGLGGGF---GGL----SL--------SGG------GGGGGFGLGGG
GGSSFGLGGGVGSGFGLGGGGGSSFGLGVGGG--------------GGGG-GGGYSFGSG
GGLGLG---AG-----------GGFGGGF-GGGS------GLGTASSYSHAG-------G
GSST--------------LST---------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

----------------------------MP--NPLNHSD---------------------
LEEIFQPSPALRRY-KGEGEDLLLRITEPPSSSELC--------YCLS-KTSPLLGPSAL
RITMSRQSSVS--FQ-SGGRRGFSASSAITPS-----VSRT-SFSSVS-MSRAGGGGGGG
GYGRVS--------------------------VG-------GS---GGGFGSRSLYNFGM
S-KRISMGGS-----G--GFRSG-------------YGG--RV----GGGYGFGGGA-G-
--------------SGFGFG--GGAGGG-------------------------L----GL
G--GG-AGFGG-GYGGAGFP------VC--PPGGI------QEVTVNQSLLAPL----NL
QIDPTIQR--VRTEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGHK----TTRQNL--EPLFE-SYINNLRRQLDSILN
DRGRLDSELRN-MQDTVEDFKNK-YEDEINKRTT---VENDFVILK--K---DVDTTYMS
KVELEAKVESLGDEVNFTRTLFEM-----ELSQMQGHVSDT----NVVLSMDNNRNLDLN
SIIA-EVKAQYEDIAN-RSRTEAESWYQTK--YEELQQTAGRHGDDLRNTKHEISEMN--
RMIQRLRAE-I--DNIKK------------------------------------------
-----Q-CA--NLQASIADAEQ-RGELAL-KDARAKL----AELEDALQKAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEE--------------------------C-RLS-G
EG--VG-PV-------N-ISVVTSSV----------------------------------
------------SSGYGSG--GGYGS----G---GGYGSGGGYG--LGGG----L-----
-----G----------------------------------------GGSG-----GYSY-
-----------------------SS---------GGG--GGLSVGG-------------S
GFSSG---SGRGLGL--SLG--GGGG-SSSSVKFV----STTS-S---------------
------------------------------------------------------------
------------SSRKSFKS----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSS
R--VTQKSYK--VS--TSDPRAFSSHPFTNAPD-----AHI-SSA-L-------------
-------------------------------------------------------SQVGR
----------------------GS-----------SFRGS------------LGSSM---
--------------TGLQ------------------------------------------
------------------------------GMGGI------TAVSVNQSLLNPL----KL
EVDPNIQA--VCT QEKEQIKSVNNKFASF------IDK--VQ------------------
----HLEQQNK-ILDTKWSLLEQ-QNT-----AQSNI--DKMSE-SYINNLQRQLDTLGQ
EKLKLEVEVGN-MQSLVEDFKNK-YEEEIKECAD---MGNEFVLTK--K---GVDEAYMN
KVELESHLEGLTNEINFLRQLYF---------------WDT----SVVLSVDNSHSLDLD
GIIV-EVKAQYKEIAN-RSWAEAETMYQIK--YEELQTLAGKHGDDLRHTKMEISDVN--
QNISQLHAE-I--KGLKN------------------------------------------
-----Q-RA--FLEATIADAEQ-RGELAV-KDAHAKV----AKLEASLQQAKQDMAQQLQ
EYQELMNIKLALNIEITICHKLLEGEES---------------------------RLE-S
---GM---Q--------TMSIHTKTTSG--------------------------------
---------------YSG---------------------GLGS-----------------
---AYG------------------------------SLTSPGLCYGLS--------TF--
--------------------------------QS--------SFGPGR---------GST
SLSCK-----------------------------I------EIRDGKLVSESSDVLSK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTQKSYK--MST--SGPRAFSSRSFTSGPG-----ARI-SSSSF-------------
-------------------------------------------------------SRVGS
S---------------------SS-----------SFRGS------------LGTGV---
--------------GL---G----------------------------------------
---------------GF---GGA-------GVGGI------TAVTVNQSLLSPL----KL
EVDPNIQA--VRT QEKEQIKSLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQQ-QKT-----SRSNM--DNMFE-SYINNLRRQLEALGQ
EKLKLEAELGN-MQGLVEDFKNK-YEDEINKRTE---MENEFVLIK--K---DVDEAYMN
KVELESRLEGLTDEINFLRQIHEE-----EIRELQSQISDT----SVVLSMDNSRSLDMD
GIIA-EVRAQYEDIAN-RSRAEAETMYQIK--YEELQTLAGKHGDDLRRTKTEISEMN--
RNINRLQAE-I--EALKG------------------------------------------
-----Q-RA--SLEAAIADAEQ-RGEMAI-KDAQTKL----AELEAALQRAKQDMARQLR
EYQELMNVKLALDIEITTYRKLLEGEES---------------------------RLE-S
---GM---Q--------NMSIHTKTTSG--------------------------------
---------------YSG---------------------GLSS-----------------
---SYG------------------------------GLTSPGFSYGMSSF-------Q--
--------------------------------PG---------FGSAG---------GSN
TFSRT---------------------TKAVVVKKI------ETRDGKLVSESSDVVSK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MLRQSSVS--F-QSGGRKGFSAASAVTPS-----ASRT-SFSSVS-VSRSGGGGGGA
GFGRAS--------------------------GA-----------CGPGFGSRSLYNLGG
S-KRISTSPG----GG--GVGTA-------------VVT---S----SVSSGYGSGG-G-
--------------SGFGLG--GG--L------GG-----------------GL----GG
G--SG-YSYGG-GWVGRGFP------VC--PPGGI------QEVTINQSLLAPL----NL
QIDPTIQR--VRTEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWQLLQQQGTK----TVNQNL--EPLFE-SYISNLRRQLDSILS
ERGRLDSELRG-MQDLVEDFKAK-YEDEINKRTA---AENEFVTLK--K---DVDAAYMN
KVELTAKVDSLMDEINFLRALYEM-----ELSQMQTQISDT----SVVLTMDNNRCLDLD
SIIA-EVKAQYEEIAQ-RSRAEAESWYQSK--YEELQQTAGRHGDDLRNTKHEISEMN--
RMIQRLRSE-I--DHVKK------------------------------------------
-----Q-CA--NLQAAIADAEQ-RGELAL-KDARVKL----EELEAALQKAKQDMARQLR
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VG-PVNILSR--P-PRVPSHPSPR--------------------------------
------------REGLGPSSPL-FSP----HDLFSPFPSSS--SRGL-------------
---------------------------------------SGGLSVGG--------SSFS-
-----------------------SSSG--------------RCLG--------------G
GFGSG---S-----------------TGSSSVRFS----TTTS-----------------
------------------------------------------------------------
------------SSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQACKK--SF-SCGSQGFSGHSAVVSG------SSR-S-SC---VARSGAA-S--
-----GG-------------------------ACGFR----SG---AGSLGSHSLYSLGG
S-KSISISVAAGGS-RTGGFSGGRS------SCGSGFGSGYGGSLGGSRG----------
------MGA-------------------------------------------GFGGPSGF
GGAG--------GFGR---PGSFGP-GS--CPGGI------QEVTINQSLLQPL----NV
EIDPQIGQ--VKA QEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWELLQQQTTRSG--SGPQNL--EPFFE-SYISCLRKQLDSLLG
AKGSLEGELKS-MQDLVEDFKKK-YEEEINRRTA---AENEFVGLK--K---DVDGAFMN
KVELQAKVDSLTDEINFLRTLYDM-----ELSQMQSHVSDT----SVVLSMDNNRCLDLD
SIIA-EVKAQYEDIAQ-KSKAEAEALYQTK--LGELQTTAGRHGDDLRSTKSEIMDLN--
RMIQRLRAE-I--ENVKK------------------------------------------
-----Q-NT--NMQTSIAEAEQ-RGERAL-KDADTKF----QDLQVALQKAKEDMARLLK
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EFQNA---V--------SISVVSNVTS---------------------------------
--------TS-S----NGGFRGTGGS----NY--G----GD-------------------
----------------SSGRSG------------------------GSSS--S-------
-----------S------------SRGSSSRGSS------GSRLGSGGSI--SV-SQQRM
GFNSG--GS-QTSVGSSYKS----GRGGSSSVQFS----QTT------------------
------------------------------------------------------------
----------SSS-QQRSK-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
MA--STSTTIR--SH-SSSRRGFSANSARLPG-----VSRS-GFSSIS-VSRSRGSGGLG
G-------------------------------AC-----------GGAGFGSRSLYGLGG
S-KRISIGGG----SC--AISGG-------------YGS--RA----GGSYGFGG-A-G-
--------------SGFGFG--GG--A------GI-----------------GF----GL
G--GG-AGLAG-GFGGPGFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPAIQR--VRA EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVRQNL--EPLFE-QYINNLRRQLDNIVG
ERGRLDSELRN-MQDLVEDLKNK-YEDEINKRTA---AENEFVTLK--K---DVDAAYMN
KVELQAKADTLTDEINFLRALYDA-----ELSQMQTHISDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEEIAQ-RSRAEAESWYQTK--YEELQITAGRHGDDLRNTKQEIAEIN--
RMIQRLRSE-I--DHVKK------------------------------------------
-----Q-CA--NLQAAIADAEQ-RGEMAL-KDAKNKL----EGLEDALQKAKQDLARLLK
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLN-G
EG--VG-QV-------N-ISVVQSTV----------------------------------
------------SSGYGGASG-------------------------V-------------
---------------------------------------GSGLGLGGGSS----YS----
-----------------------YGSG--------------LGVG--------------G
GFSSS---SGRATG--GGLS--SVGGG-SSTIKYT----TTSS-----------------
------------------------------------------------------------
------------SSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
----------------------------------------------------------MR
S-SLSRQTFST--------KGGFSSNSASGG---GGSRMRT-SYSSVT-MSRGS--GGG-
--------------------------G---GV---------RSGSSSGGFGSRSLYNLGG
--KNISVSMACGASSG-RAL----------------------------------------
--------------GGFG--------------------SGAYV-----------------
-------GLG-------ASRQTFGP-VC--PPGGI------QEVTVNQSLLTPL----NV
EIDPEIQR--VRTQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQSQNTG--VAR-SL--EPFFE-NYLSTLRRQLDTKQS
ERGRLDMELRN-VQDNLEDFKNK-YEDEINKRTA---LENEFVLLK--K---DVDAAYMG
RMDLHGKVDSLTQEIDFLQQLFEM-----ELSQVQTNVSDT----NVILSMDNNRSLDLD
SIIA-EVKAQYELIAQ-KSRAEAESWYQTK--YEELQVTAGKHGDSLRDTKNEIAELT--
RTTQRLQGE-V--DAAKK------------------------------------------
-----Q-CQ--QLQTAIAEAEQ-NGEMAL-KDAKKKL----GDLDTALHQAKEDLARMLR
EYQDLVSVKLALDMEIATYRKLLESEE--------------------------S-RMS-G
DCPSA---I--------SISVTGNSTSVCA------------------------------
-----------------GG--------------AAGFGNGLSLGGA---GG--ASKGGFG
SS----------------------------------------VSYGA----------A--
KGGQVSG--GTSILRKT--TTVKTSSRRY-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
MA--STSTTIR--SH-SSSRRGFSANSARLPG-----VSRS-GFSSIS-VSRSRGSGGLG
G-------------------------------AC-----------GGAGFGSRSLYGLGG
S-KRISIGGG----SC--AISGG-------------YGS--RA----GGSYGFGG-A-G-
--------------SGFGFG--GG--A------GI-----------------GF----GL
G--GG-AGLAG-GFGGPGFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPAIQR--VRA EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVRQNL--EPLFE-QYINNLRRQLDSIVG
ERGRLDSELRN-MQDLVEDLKNK-YEDEINKRTA---AENEFVTLK--K---DVDAAYMN
KVELQAKADTLTDEINFLRALYDA-----ELSQMQTHISDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEEIAQ-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEIAEIN--
RMIQRLRSE-I--DHVKK------------------------------------------
-----Q-CA--SLQAAIADAEQ-RGEMAL-KDAKNKL----EGLEDALQKAKQDLARLLK
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLN-G
EG--VG-QV-------N-VSVVQSTI----------------------------------
------------SSGYGGASG-------------------------V-------------
---------------------------------------GSGLGLGGGSS----YS----
-----------------------YGSG--------------LGIG--------------G
GFSSS---SGRAIG--GGLS--SVGGG-SSTIKYT----TTSS-----------------
------------------------------------------------------------
------------SSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQSSVS--FR-SGGSRSFSAASAITPS-----VSRT-SFTSV---SRSGG----G
GGGRVS--------------------------LG-------GV-YGAGGFGSRSLYNLGG
S-KRISFSTS----GG--SFRNQ-------------FGGAGGG-------FGFRGGA-G-
--------------SGFGFG--GGAGGG------------------------GF----GL
G--GAAGFGGG-GYGGAGFP------VC--PPGGI------QEVTINQNLLTPL----NL
QIDPTIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVRQSL--EPLFE-QYINNLRRQLDGILG
ERGRLDSELRN-MQDLVEDFKNK-YEDEINKRTT---AENEFVMLK--K---DVDAAYMN
KVELEAKVDALMDEINFMKMFFDA-----ELSQMQTHISDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEDIAN-RSRTEAESWYQTK--YEELQQTAGRHGDDLRNTKHEISEMN--
RMIQRLRAE-I--DNVKK------------------------------------------
-----Q-CA--NLQNAIADAEQ-RGELAL-KDARNKL----AELEEALQKAKQDMARLLR
EYQELMNTKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VG-PV-------N-ISVVTNSV----------------------------------
------------SSGYGGGS--GFGG----G---S--GFGGGLGGGLGGG----L-----
-----G----------------------------------------GG-G----GGYYS-
-----------------------SSSG-----GVGLG--GGLSVGG-------------S
GFSAS---SGRGMGMGFGS----GGS-SGSSVKFV----STTS-S---------------
------------------------------------------------------------
-------------SRRSFKS----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQSSVS--FR-SGGSRSFSASSAITPS-----VSRT-SFSSV---SRSGG----G
GGGRIS--------------------------LG-------GA-CGAGGYGSRSLYNVGG
S-KRISFSSG----GG--SFRNQ-------------FGAGG---------FGFGGGA-G-
--------------SGFGFG--GGAG-S------------------------GF----GF
G--GGAGFG-G-GYGGAGFP------VC--PPGGI------QEVTVNQNLLTPL----NL
QIDPTIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWALLQEQGTK----TIKQNL--DPLFE-QYINNLRRQLDGVLG
ERGRLDSELRN-MQDLVEDYKNK-YEDEINKRTT---AENEFVMLK--K---DVDAAYMN
KVELEARVDALMDEINFIKMFFDA-----ELSQMQTHVSDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEDIAN-RSRTEAESWYQTK--YEELQQTAGRHGDDLRNTKHEISEMN--
RMIQRLRSE-I--DNVKK------------------------------------------
-----Q-CA--NLQNAIAEAEQ-RGELAL-KDARNKL----TELEEALQKAKQDMARLLR
EYQELMNTKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VG-PV-------N-ISVVTNSV----------------------------------
------------SSGYGGGS-S---I----G---VGSGFGGG----LGSG----F-----
-----A----------------------------------------GGL-----GPRFT-
-----------------------RGGG-----GLGLG--SGLSVGG-------------S
GFSAG---SSQG-SMSFGS----GGG-SGSSVKFV----STTS-S---------------
------------------------------------------------------------
-------------SRRSFKS----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MTSKSTVK--SY-SSSHRGFSSGSARVPG-----VSRC-GFSSVS-VSRSRGSGGLG
G-------------------------------VC-----------GGAGFGSRSLYNLGG
S-KRISIGGG----SC--AVGGG-------------YGS--RV----GGGYGFGGGA-G-
--------------SGFGFG--GG--A------GA-----------------GF----GL
G--GG-AGFGG-GYGGSGFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPSIQR--VRTEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVRQNL--DPLFE-QYINNLRRQLDSIVG
ERGRLDSELRG-MQDMVEDFKNK-YEDEINKRTA---AENEFVTLK--K---DVDGAYMN
KVELQAKVDSLADEIQFLRVLYDT-----ELSQMQTHISDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEEIAQ-RSRAEAESWYQSK--YEELQVTAGRHGDDLRNTKQEISEMN--
RMIQKLRAE-I--DSVKK------------------------------------------
-----Q-CS--SLQTAIADAEQ-RGELAL-KDARAKL----VDLEEALQKAKQDMARLLR
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------S-RLS-G
EG--VS-PV-------N-ISVVTSTV----------------------------------
------------SSGYGGGSGI-----------------GC--G----------------
-----------------------------------------SLGVGGGSG----YS----
-----------------------FTTS----GGHSLG--AGLGS---------------S
GFSAS---SSRGLG--G---------S-GSSVKIV------STTS---------------
------------------------------------------------------------
------------SSRKSYQH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
-----------------------------------------------------RRRIESC
S-------------GAMSRSVSFSSRSAAAPGG----IRQY-RVSTV----SSG------
-----------------------------------RNTGGGFCLSRAGGFGSSSLYNLGS
ANKRISAGSG-------ASSYSVRS-----------------------------------
---------------GYGLG-------AG-------------------------------
--------------------AGAGY-----GPAGI------QEVTINPSLLTPL----NL
QIDPAIQQ--VRKEEKEQIKSLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQDQKAT-----RS-NI--APLFE-TYIGNLRRQLDGLMN
DKGRLEGELKN-MQDLVEDFKNK-YEDEINKRTT---AENDFVILK--K---DVDSAYMN
KVELEAKVDALMDEINFLRSLYEA-----ELRELQTQISDT----SVVLSMDNTRTLDLD
GIIA-EVKAQYEDMAK-KSQVEAESMYQKK--FESLQATAGQHGDELRNTKTEITELN--
RMIHRLQAE-I--DNLKN------------------------------------------
-----Q-QIWMGMESDIAEAEE-RGELAL-KDARGKL----AELEAALIKAKQDMARQLR
EYQELMSVKLALDIEIATYRKLLEGEE--------------------------S-RLS-G
DHVGN---V--------SVSMVNSSAGGGYSGAG--------------------------
-G------------------------------------YGFGGGLHLGSGM-GSSGLSFS
SGGSPGGV----------------------------------------------------
---------TAYSMTTTSSSRRSVRK----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
----------------------------------------------------------MR
-SSVSRQTYSI--------KGGFSSNSASGG---GGSQART-SFSSVT-VSRNSGSGGG-
--------------------------A--------------RCGPSTGGFGSRSLYNLGG
H-KSISVSVAGGASSG-RAL----------------------------------------
--------------GGFGFG------------------SRAFT-----------------
-------GQG-------AGRQTFGP-AC--PPGGI------QEVTVNQSLLTPL----HV
EIDPEIQR--VRTQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQGQNLG--VTRNNL--EPLFE-AYLGSMRSTLDRLQS
ERGRLDSELRN-VQDLVEDFKNK-YEDEINKRTA---AENEFVVLK--K---DVDAAYMG
RMDLHGKVGTLTQEIDFLQQLYEM-----ELSQVQTHVSDT----NVVLSMDNNRNLDLD
SIIA-EVKAQYELIAQ-RSRAEAEAWYQTK--YEELQVTAGKHGDNLRDTKNEIAELT--
RTIQRLQGE-V--DAAKK------------------------------------------
-----Q-CQ--QLQTAIEEAEQ-RGELAL-KDAQKKL----GDLDVALHQAKEDLARLLR
DYQELMNVKLALDVEIATYRKLLESEE--------------------------S-RMS-G
ECPSA---V--------SISVTGNSTTVCG------------------------------
-----------------G---------------------GIALGGN---GG--ATKGGFS
TN----------------------------------------VGYST----------V--
KGGPVSG--GTSILRKT--TTVKTSSRRY-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQASKT--S--GGGSQGFSGRSAVVSG------SSR-M-SC---VTRSGVA-G--
-----GG-------------------------AYGFR----SG---AGGFGSRSLYNLGG
N-KSISISVAAGGP-RAGGFGGGRS------SCS--FAGGYGGGFGGGYGGGFGGGFGGV
RG----MGGGFGGAGGFG--------------GA-----SGFGGP------GGFGSPGGF
GP------------------------GG--FPGGI------QEVTINQSLLQPL----NV
EIDPQIGQ--VKA QEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQQQSTSSI--SGTNNL--EPLFE-NHINYLRSYLDNILG
ERGRLDSEMRN-MQDLVEDFKKK-YEDEINKRTA---AENEFVTLK--K---DVDGAYMN
KVELQAKVDALIDEINFLRTLYDA-----ELSQMQSHISDT----SVVLSMDNNRSLDLD
SIIA-EVRAQYEDIAQ-RSKAEAEALYQTK--LGELQTTAGRHGDDLRNTKSEIIELN--
RMIQRLRAE-I--ESIKK------------------------------------------
-----Q-NA--NLQTAIVEAEQ-RGEMAL-KDANAKL----QELQAALQQAKDDLARLLR
DYQELMNVKLALDVEIATYRKLLEGEE--------------------------Y-RMS-G
ECPSA---V--------SISVVSSNTT---------------------------------
--------S-ASAGGYAGG-YGGG------------VGGGLGG-----------------
--------------------GL----GAGG---------GSSSGFGRGGG-G-GIGGG--
I--------GGGF-----------------------------GGGSSGGF--SGGSGF--
GSSSG--AR-YGVSGGGFSS----ASNRGGSIKFS----QSS------------------
------------------------------------------------------------
----------QSS-QRYSR-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSV
H-------------Y---STQVFSSRSAALPR----------------------------
------------------------------------------------------------
-----------------RGX----------------------------------------
---------------XXX------------------------------------------
----------------X-------X-----XXXXX------XXVTINQNLLAPL----RS
NIDPSIRQ--VRQEEREQIKTLNNKFASF------IDK--VQ------------------
----FLEQQNK-MLETKWALLQEQKSA-----KSSIL--PRIFE-AQISSLRGQLEKLQL
DRGRLEAELRS-MQDVVEDFKNK-YEEEMNHRMA---AENEFVVLK--K---DVDNTYMN
KVDLQAKVDGLSDEINFLKTLNEM-----ELAELQSQISDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEEMAN-RSRAEAEASYQKK--FEILQAQSGKHGEDLRNTRNEIVEMN--
RAIQRLQAE-I--DNIKN------------------------------------------
-----Q-RA--KLEAAIAEAEE-HGELAL-KDAYAKQ----KELEAALQQAKQDIARQLR
EYQELMNIKLALDIEIATYCKLLEGEE--------------------------S-RLT-G
DGVGA---A--------NISM---------------------------------------
----VNSS-S---------G----------------GGKGLVFGG-----TMGSNALRFS
S------GGPGA------------------------------------------------
--------IKAYSIRTTSTTRESTHY----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------ISQVFSSRSAAFPGR----SPQV-RLSLG----RQRG-----
----------------------------------------------F---GSSSLYGLG-
------------SA-RPRMAV--RS-----------------------------------
---------------SYG------------------------------------------
----------------G-------P-----VGAGI------REVSINQSLLAPL----RM
DIDPTLQQ--VRQ EEHEQIKTLNNKFASF------IDK--VQ------------------
----FLEQQNK-MLETKWALLQEQKSA-----KSSRL--PSIFE-AQINSLRRQLEALQM
DGGRLEVELKS-AQEVVEDFKNK-YEEEINHRTA---AENEFVVLK--K---DVDAAFMN
KVELESKMDSLNDEINFLKTLYET-----ELAELQSQISDT----SVVLSMDNSRSLELD
GIIA-EVKAQYEEMAN-RSRADTEAWYQTK--VETLQAQAGEHGNNLRNTRNEISELN--
RMIQRLQAE-I--ENAKN------------------------------------------
-----Q-NG--KLETTIAEAEE-RGEFAL-KDARHKQ----EELEAALQQSKQGMAQMLR
EYQDLLTVKLALDMEIATYRKLLEEGQ--------------------------E------
--YGS---L--------CLSL---------------------------------------
-PAMVNS----------IGG----------------SGRGLVFGG-----TMGSNALSFS
SG-----GGPRA------------------------------------------------
--------LKAYSIRTTSATRRSTHN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MNRQACKI--S--GGRSQGFSGRSAVVSG------GSR-M-SC---VARTG------
-----GS-------------------------SGGFR----SG---AGNFGSQSLYNLGG
N-KRISISVAAGGS-RAGGFGG-YN------SCGSGFGGSYGGAFGGGSGGNFGSGFGGS
RG----MGSVFGGAGGFG--------------GA-----GGSGG---------------L
----GFS--------G---PGGFGP-GC--FPGGI------QEVTVNQSLLQPL----SV
EIDPQIGQ--VKA QEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWELLQQQGSGST--TGTNNL--EPLFE-NYINHLRSHLDGILG
ERGHLDSELRN-MQDLVEDFKKK-YEDEINKRTV---VENEFVTLK--K---DVDAAYLN
KVELQAKMDALVDEINFMRTLCDA-----ELSQMQSHVSDT----SVILSMDNNRDLDLD
SIIE-EVRGQYEDIAQ-RSKAEAEVLYQTK--LGELQTTAGRHGDDLRNTKSEIMELN--
RMIQRLRAE-I--ENVKK------------------------------------------
-----Q-NA--NLQTSIAEAEQ-RGEMAL-KDANAKL----QDLQVALQKAKDDLARLLR
DYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RMS-G
ECQSA---V--------SISVVNSSST---------------------------------
--------TSALAGGYGGS-YGVG------------FSVGG-------------------
-----------------------------T---------GTGSGFGLGGG-S--------
-GIGSGSGFGSSS-----------------------------GFGGSSSS--GGGSSF--
GSGSV--SH-SGVSGRGFGS----GSNRSGSVQFS----QSS------------------
------------------------------------------------------------
----------QRY-SR--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--------MSS--NS-TMIHRDFRTSSARVPA-----GSRS-GFSSVS-MSHFRGGAGLG
G-------------------------------AC-----------GGAGFGSRSLYGLGS
S-KRISIGGS----NF--VMGDR-------------YGS--RV----GRSFGFGGGRVS-
--------------SGYGFC--SG--A------GG-----------------GF----GL
G--GG-AGFGG-GYGGSGFP------VC--PPGGI------QEVTINQSLLTPL----NL
QIDPTIQQ--VRTEEWEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGNK----TIRQNL--EPFFE-QYINHLHRQLNSMQG
ERGRLDSELRG-MQDLVEDYKNK-YEDEINKRAA---AENEFVTLK--K---DVDAAYMN
KVELQAKADALRDETDFLQL-FHE-----ELSQIQTHISDT----SVVLSMDNNRNLDLD
SIIA-EVKDRYEEIAQ-RSRAEAESWYHTK--YEELQVTAGRHGDDLRNMKQEISEMN--
HIIQRLRSE-I--DHVKK------------------------------------------
-----Q-CA--NLQAAIVDAEQ-DGEKAL-SDAKNKL----ARLEDALQKAKQDMTRLLR
EYQELTNVKLALDLEIIAYRKLLEGEE--------------------------Y-RLN-G
EG--VG-QV-------N-ISVTQSTV----------------------------------
------------SSGYGSSSG-------------------------V-------------
---------------------------------------SSGLGPGAGSG----YF----
-----------------------YGSD--------------LSLR--------------S
GFNSS---GGRGIA--GGLG--SSGGS-SSTIKYI----TTSS-----------------
------------------------------------------------------------
------------TSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MIARQSSVR-----G-ASRGFSSGSAI-AGG----VKRV-AFSSGS---MSGGA----
-----------------------------------------GRCS-SGGFGSRSLYNLGG
H-KSISMSVAGSCQ-GG-GYGGAGG-----------FGVGG-------------------
----------------YG----------------AGFGAGGFG-----------------
---GGFGG----SFN--GRGGPGFP-VC--PAGGI------QEVTINQSLLTPL----QV
EIDPEIQK--IRTA EREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQQQTTTT----SPKSL--DPFFE-TYINALRKNLDTLSN
DKGRLQSELKM-MQDSVEDFKTK-YEEEINKRTA---AENDFVVLK--K---DVDAAYMI
KVELEAKMESLKDEINFTRVLYEA-----ELAQMQTHVSDT----SVVLSMDNNRNLDLD
GIIA-EVRAQYEDIAR-KSKAEVESWYQIK--VQQLQMSADQHGDSLKTTKNEISELN--
RMIQRLRAE-I--ENIKK------------------------------------------
-----Q-SQ--TLQASVADAEQ-RGELAL-KDAYSKR----AELETALQKAKEDLARLLR
DYQALMNVKLALDVEIATYRKLLEGEE--------------------------C-RMS-G
ECKSA---V--------SISVVGGSASIGG------------------------------
------------------------S------------------------------GL---
---GLGS------------------------GFCSGSG--SGSGFGF--G-GG-------
----IYGGSGSKITSSATIT--KRSPR---------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--M-SRQSSIT--FQSG-SRRGFSTTSATTPA-----TGRS-RFSSVS-VARSAA--GNG
GLGRIS--------------------------SA------------GASFGSCSLYNLGG
A-KRVSISGC-GSS-----FRSG-------------FGG--RA----SSGFGV-----N-
--------------SGFGYG--GGVGGGF-------------------------------
--------------SGPSFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPTIQQ--VRA EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQGSR----TVRQNL--EPLFD-SYISELRRQLESITT
ERGRLEAELRN-MQDVVEDFKVR-YEDEINKRTA---AENEFVALK--K---DVDAAYMN
KVELEAKVKSLPEEINFLHSVFDA-----ELSQLQTQVSDT----SVVLSMDNSRNLDLD
SIIA-EVKAQYEDIAN-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEISEMN--
RMIQRLRAE-I--DSVKK------------------------------------------
-----Q-CS--SLQTAIADAEQ-RGELAL-KDARAKL----VDLEEALQKAKQDMARLLR
EYQELMNIKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VS-PVNIS--------VVTSTL----------------------------------
------------SSGYGSGS--GIG-----------------------------------
---------------------------------------GGSLGLGGGSG----YSFTT-
-----------------------SG-------GHSLG--A--GLGG-------------S
GFSAT---SNRGLGG------------SGSSVKFV----STTS-----------------
------------------------------------------------------------
------------SSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQSTVS--FHSG-NHRGFSTASAITPS-----GGHS-RFSSVS-LARSTG--GHA
GLGRAS--------------------------GA-------G---GAAGFGSHSLYNLGG
T-KRVSVGGC-GSN-----FQSG-------------FGG--RV----SSGFGVNS-----
------------------------------------------------------------
----------G-PYGGPSFP------VD--PSGGI------QEVIVNQSLLTPL----NL
QIDPSIQQ--VRKEEKEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQEHGSK----TVRHNL--EPFFD-AYISDLRRQLDSVTT
ERGRLDAELRS-MQDVVEDFKVR-YEDEINKRTA---AENEFVALK--K---DVDAAYMS
KVELEAKVNSLTDEINFCQMLFEA-----ELSQMHTQVSDT----SVVLSMDNNRSLDLG
NIIA-EVKAQYEDIAN-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEISEMN--
RMIQRLKAE-I--DSVKK------------------------------------------
-----Q-CE--SLQATIADAEQ-RGELAL-KDARAKL----VDLEEALQKAKQDMARLLR
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------Y-RLS-G
EG--IS-PVNIS--------VVTSTM----------------------------------
------------SSGYGSGS--SIG-----------------------------------
---------------------------------------AGSLGLSGGSG----YSFTT-
-----------------------SG-------GHSLS--T--GLGS-------------S
GFST----SSRGHGG------------SSSSIKLV----STTS-----------------
------------------------------------------------------------
------------SSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSTKTTIR--SQ--TSHRGFSAGSARVPG-----LNRS-GFSSVS-VCRSRGSGGSG
A-------------------------------VC-----------GGAGFGSRSLYGVRS
S-KRISIGGG----SC--GIGGG-------------YGS--RV----GGGFGFGGGA-S-
--------------SGFGFG--GG--A------GS-----------------GF----GF
G--SG-AGFGG-GYGGAGFP------VC--PPGGI------Q E-----------------
-------R--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWALLQEQGTK----TVRQNL--EPLFE-QYISNLRRQLDGVLG
ERGRLDSELRS-MQETVEDYKNK-YEDEINKRTA---AENEFVTLK--K---DVDAAYMN
KVELQAKTDSLTDEINFLRVLYDA-----ELSQMQTHISDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEEIAQ-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKEEIAELN--
RMIRRLQAE-I--ENLKN------------------------------------------
-----Q-IA--NLQAAIAEAEQ-RGENAL-KDARGKL----EGLEDALQKAKQDMARLLK
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLN-G
EG--VG-PV-------N-ISVVQSTM----------------------------------
------------SSGYGSAG-------------------GA--S----------------
----------------------------------------SGLGLGGG-S----SYSYS-
-------------------------SS--------------HGLG--------------G
GFSSG---SGRGLS--GGLS--SSGGS-SSTIKYT----TT-S-----------------
------------------------------------------------------------
------------SSRKSYRH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R-V-TQKSYK--VST--SAPRSFSSRSYTSGPG-----SRI-SSSAF-------------
-------------------------------------------------------SRVGS
S----------------------S-----------SFRGG------------LGTGM---
--------------SM---A----------------------------------------
---------------GSYGG-AP-------GLGGI------TAVTVNQSLLSPL----KL
EVDPNIQA--VRTQEKKIMKSVNQNLATF------TDK--VR------------------
----HLEQQNK-VLETKWNLLQQ-QKT-----ARSNI--DNMFE-SYINNLRRQLETLAQ
EKLKLEVELGN-MQGLVEDFKTK-YEDEIQKRTD---MENEFVIIK--K---DVDEAYMN
KVELESRLEGLTDEINFYRQLYEE-----EIREMQSQISDT----SVVLSMDNNRNLDLD
GIIA-EVKAQYEEIAN-RSRAEAEAMYQIK--YEELQTLAGKHGDDLRRTKTEISEMN--
RNINRLQAE-I--EGLKG------------------------------------------
-----Q-RA--SLEAAIADAEQ-RGEMAV-KDAQAKL----AELEAALRNAKQDMARQLR
EYQELMNVKLALDVEIATYRKLLEGEES---------------------------RLE-S
---GM---Q--------NMSIHTKTTSG--------------------------------
---------------YAG---------------------GLTS-----------------
---SYG---------------------------------TPGFNYSLS------------
---------------------------------P--------G----------------S
FS--R-------------------TSSKPVVVKKI------ETRDGKLVSESSDVLSK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
-AM-SRQSTIT--FQTG-SRRGFSTTSA---------SRRP-RFSSAS-LARTTG--GSG
GLGRIS--------------------------GP------------GASFGSRSLYNLGG
T-KRVSISGS-GNN-----FRSG-------------FGG--RA----SSGFGV-----S-
--------------SGFGYG--GGVGGGY-------------------------------
--------------GSSGFP------VC--PPGGI------QEVTVNHSLLTPL----NL
QIDPTIQR--VRKEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWSLLQEQGTK----TVRQNL--EPFFD-AYLNDLRRQLDSVTS
ERGRLDAELRN-TQDVVEDFKVR-YEDEINKRTA---AENEFVALK--K---DVDAAYMN
KVELEAKVSCLTDEINFLRMLYEE-----ELSQMQTQVSDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEDIAN-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEISEMN--
RMIQRLRTE-I--DNVKK------------------------------------------
-----Q-CS--SLQTAIADAEQ-RGELAL-KDARAKL----VDLEEALQKAKQDMARLLR
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VS-PVNIS--------VVTSTV----------------------------------
------------SSGYGSGS--GIG-----------------------------------
---------------------------------------GGGLGLGGGSG----YSFNT-
-----------------------SG-------GHSLG--M--GLGG-------------S
GFSAS---SSRGLGG------------NGSSVKFV----STTS-----------------
------------------------------------------------------------
------------SSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--TMSSKSTIR--TQ-SSSHRGFSASSARVPG-----VSRS-GFSSVS-VCRSRGSGGLG
G-------------------------------VC-----------GGAGFGSRSLYGLGG
S-KRISIGGG----SC--AVSGG-------------YGG--RV----GGGFGFGGGA-G-
--------------SGFGFG--GG--S------GG-----------------GF----GL
G--GG-AGFGG-GYGGAGFP------VC--PPGGI------QEVTINQNLLTPL----NL
QIDPTIQR--VRTEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVRQNL--EPLFE-QYINNLRRQLDSIVG
ERGRLDSELRG-MQDMVEDFKNK-YEDEINKRTA---AENEFVTLK--K---DVDAAYMN
KVELQAKVDALMDEINFTRAFYEA-----ELAQMQTHISDT----SVVLSMDNNRDLDLG
SIIA-EVKAQYEEIAQ-RSRTEAESWYQSK--YEELQVTAGRHGDDLRNTKQEIAEIN--
RMIQRLRSE-I--DHVKK------------------------------------------
-----Q-CA--NLQAAIADAEQ-RGELAL-KDAKSKL----VELEDALQKAKQDMARLLK
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VG-PV-------N-ISVVQSTV----------------------------------
------------SSGYGSAGG-------------------------V-------------
---------------------------------------GSGFGLGGGSG----YS----
-----------------------YGSG-----H-SLR--G--------------------
GFSSG---SGRGFG--GGLS--SAGGS-SSTIKYS----TTS--S---------------
------------------------------------------------------------
------------TTRKGYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
-------------------------------P----------------------------
------------------------------------------------------------
-----------------RGPV--RS-----------------------------------
---------------VFA------------------------------------------
----------------G-------S-----VGAGI------REVTINQNLLAPL----RS
KIDPSIRQ--VRL EEREQIKILNNKFASF------IDK--VQ------------------
----FLEQQNK-MLETKWALLQEQKSA-----KSSSL--PRVFE-AQIASLRGQLEKLQL
DRGCLEAELRS-MQDVVEDFKNK-YEEETNHRMA---AENEFVVLK--K---DVDTIYMN
KVDLQAKVDSLSDEINFLKTLNEM-----ELAELQSQISDT----SVVLSMDNNRSLDMD
SIIA-EVKAQYEEMAN-RSRTEAEALYQKK--FEILQAQSGKHGENLRNTRNEIVELN--
RAIQRLQAE-I--DNIKN------------------------------------------
-----Q-HA--KLEASIPEAEE-HGELAL-KDAHAKQ----KELEAALQQAKQDIARQLR
EYQELMNIKLALDMEIATYRKLLEGEE--------------------------S-RLS-G
DGVAA---A--------NISV---------------------------------------
----VNSS-G---------G----------------GGRGLVFGG-----TMGSNALRFS
S------GGPGA------------------------------------------------
--------VKAYSIRTTSTTRESTHY----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--M-SRQSSIT--FQSG-SRRGFSTTSATTPA-----AGRS-RFSSVS-MARSAV--GSG
GPGRIS--------------------------ST------------GAGFGSRSLYNLGG
T-KRASISGC-GSS-----FQSG-------------FGG--RA----SGGFGV-----S-
--------------SGSGYG--GGVGGGF-------------------------------
--------------SGPGFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPTIQR--VRA EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQGSR----TVRQNL--EPLFD-SYISELRRQLESITT
ERGRLEAELRN-MQDVVEDFKVR-YEDEINKRTA---AENEFVALK--K---DVDAAYMS
KVELEAKVKSLPEEINFLHSVFDA-----ELSQMQTQVSDT----SVVLSMDNNRHLDLD
SIIA-EVKAQYEDIAN-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEISEMN--
RMIQRLSAE-I--DSIKK------------------------------------------
-----Q-CS--SLQTAIADAEQ-RGELAL-KDARAKL----VDLEEALQKAKQDMARLLR
EYQELMNIKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VS-PVNIS--------VVTSTV----------------------------------
------------SSGYGSSS--GIG-----------------------------------
---------------------------------------GGSLGLGGGSG----YSFTT-
-----------------------SG-------GHSLG--A--GLGG-------------S
GSSAT---SSRGLAG------------SSSSVKFV----STTS-----------------
------------------------------------------------------------
------------SSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--M-SRQSSIT--FQTS-SRRGFSTTSTTTPA-----AGRS-RFSSVS-VASSAV--GSG
GPGRIS--------------------------SA------------GAGFGSRSLYNLGG
T-KRVSISGC-GSS-----FRSG-------------FGG--RA----GGGFGV-----S-
--------------SGFGYG--GGVGGGF-------------------------------
--------------SGPSFP------VC--TLGGI------QEVTVNQSLLTPL----NL
QIDPTIQR--VRA EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQGSR----TVRQNL--EPLFD-SYISELRRQLESITT
ERGRLEAELRN-MQDVVEDFKVR-YEDEINKRTA---AENEFVALK--K---DVDAAYMS
KVELEAKVKSLPEEINFLHSVFDA-----ELSQMQTQVSDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEDIAN-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEISEMN--
RMIQRLRAE-I--DSVKK------------------------------------------
-----Q-CS--SLQTAIADAEQ-RGELAL-KDARAKL----VDLEEALQKAKQDLARLLR
EYQELMNIKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VS-PVNIS--------VVTSTV----------------------------------
------------SSGYGSSS--GIG-----------------------------------
---------------------------------------GGSLGLGGGSG----YSFTT-
-----------------------SG-------GHSLG--A--GLGG-------------S
GFSAA---SSRGLGG------------SGSSVKFV----STTS-----------------
------------------------------------------------------------
------------SSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTQKSYK--VST--SGPRAFSSRSYTSGPG-----ARI-SSSSF-------------
-------------------------------------------------------SRVGS
G----------------------S-----------SFRGS------------LGTSM---
--------------GL---G----------------------------------------
---------------GFS-GG-A-------GVGGI------TAVTVNQSLLSPL----KL
EVDPNIQA--VRT QEKEQIKSLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQQ-QKT-----SRSNM--DNMFE-SYINNLRRQLETLGQ
EKLKLEAELGN-MQGLVEDFKNK-YEDEINKRTE---MENEFVLIK--K---DVDEAYMN
KVELESRLEGLTDEINFLRQIHEE-----EIRELQSQISDT----SVVLSMDNSRSLDMD
SIIA-EVRAQYEDIAN-RSRAEAESMYQIK--YEELQAQAGKHGDDLRRTKTEISEMN--
RSINRLQAE-I--DALKG------------------------------------------
-----Q-KA--TLEAAIADAEQ-RGEMAI-KDANAKL----AQLEAALQQAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEES---------------------------RLE-S
---GM---Q--------NMSIHTKTTSG--------------------------------
---------------YSG---------------------GLSS-----------------
---AYG------------------------------GLTSPGFSYGMSSF-------Q--
--------------------------------PS---------FSSLG---------GSS
TITRT----------------------KAVVVKKI------ETRDGKLVSESSDILPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
----------------------------------------------------------MR
S-SVSRQTYST--------KGGFSSNSASGG---GGSRMRT-SYSSVT-MSRSSGSGSG-
--------------------------G---VV---------RSCPGSGGFGSRSLYNLGG
--KNISVSVAGGASSG-RVL----------------------------------------
--------------GGFG--------------------SGAYV-----------------
-------GLG-------AGRQTFGP-VC--PPGGI------QEVTVNQSLLTPL----NV
EIDPEIQR--VRTQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQSQNTV--VAQ-SL--EPFFE-TYLSNLRRQLDAKQS
ERGRLDMELRS-VQDNLEDFKNK-YEDEINKRTA---LENEFVLLK--K---DVDAAYMG
RMDLHGKVDTLNQEIEFLQHLFEA-----ELSQVQTHVSDT----NVVLSMDNNRSLDLD
SIIA-EVKAQYELIAQ-KSRAEAESWYQTK--YEELQVTAGKHGDSLRDTKNEIAELT--
RTIQRLQSE-V--DATKK------------------------------------------
-----Q-CQ--QLQTAIAEAEQ-RGEMAL-KDAKKKL----GDLDIALHQAKEDLARLLR
DYQSLMNVKLALDVEIATYRKLLESEE--------------------------S-RMS-G
ECPSA---V--------SISVTGNSTSVCA------------------------------
-----------------GG--------------TTSFGSGLSLGGA---GA--ASKGGFS
TN----------------------------------------VSYGT----------A--
KGGQVSG--GTSILRKT--TTVKTSSRRY-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MNRQVCKK--SF-SGGSQGFSGCSAVVS-G-----SSR-M-SS---VARFGGA-G--
-----GG-------------------------ACGFR----SGA---GGFGSRSLYNLGG
N-KSISISVAAGGS-RAGGFGGGRS------SCG--FGGGYGSG----FGGSYGGGFGGG
--R--GVGSGFG-------------------------------GAGGFGGAGGF------
GGPGGFGGPG--SFGG---PGGFGP-GG--FSGGI------QEVTVNQSLLQPL----NV
EIDPQIGQ--VKA QEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWELLQQQTTGSG--SGPRSL--EPCFE-SYISFLRKQLDSLLG
EKGNLEGELKN-MQDVVEDFKKK-YEDEINKRTA---TENEFVGLK--K---DVDSAFMN
KVELQAKVDSLTDEVNFLRTLYEM-----ELSQMQSRVSDM----SVVLSMDNNRCLDLD
SIIA-EVRAQYEEIAQ-RSKAEAEALYQTK--LGELQTTAGRHGDDLRNTKTEIMELN--
RMIQRLRAE-I--ENVKK------------------------------------------
-----Q-NA--NLQTAITEAEQ-RGEMAV-KDANAKL----QDLQAALQKAKDDLARLLR
DYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RMS-G
ECQSA---V--------CISVVSNVTST--------------------------------
---------SGSSGSSRGIFGGVSGS----GN--GGYRGGSSSG----------------
-------------------GSSG-YEGVSG---------GSSSG-YRVVS-SG---ST--
GGRGSSGGYQ--------------------SSSS------GSRLGGAGSIS---GSHSGM
GSSSG--SV-QTSGGSGYKS----GGGGSTNIRFS----QTT------------------
------------------------------------------------------------
----------SSS-QHSSTK----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
----------------------------------------------------------MR
-SSMSRQTYST--------KGGFSSNSASGG---GGRRTHT-NFSSVT-MSRSGGSGGG-
--------------------------A--------------RCGPSMGSFGSRSLYNVGD
H-RSISVSVARGASSG-RAL----------------------------------------
--------------GGLGLG------------------SGAYV-----------------
-------GLG-------AGRQTFGP-AC--PPGGI------QEVTINQSLLTPL----NV
EIDPEIQR--VRT QEREQIKILNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQGQNMG--VTKNNL--DPLFE-TYVASLRRQLDSLQG
ERGRLDSELRN-VQDVLEDFKNK-YEDEINKRTA---GENEFVVLK--K---DVDAAYMT
RMDLDGKVNTFLQEIDFLRNLYEM-----ELSQVQTHVSDT----NVVLSMDNNRNLDLD
SIIA-EVRAQYELIAQ-RSRAEAESWYQTK--YEELQVTAGKHGDNLRDTKNEISELT--
RTIQRLQGE-V--DAAKK------------------------------------------
-----Q-CQ--QLQTAIGEAEQ-RGELAL-QDAKKKL----VDLDTALHQAKEDLARLLR
DYQALMNVKLALDVEIATYHKLLESEE--------------------------S-RMS-G
ECPSA---V--------SISVTGNSTTVSG------------------------------
-----------------GV--------------STGYGGGITLAGS---RG--DCKGGFS
SS----------------------------------------MGYST----------A--
KGGAASG--GTSILRKT--TTVKTSSRRY-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQSSVS--FR-SGGSRSFSAASAITPS-----VSRT-SFTSV---SRSGGGGGGG
GFGRIS--------------------------LG-------GAGGG-GGYGSRSLYNLGG
S-KRISISAG----GG--GFRNR-------------FGAG--A----GGGYGFGGGA-G-
--------------SGFGLG--GGAG--------G-----------------GF----GL
G--GGA-GFGG-GFGGPGFP------VC--PPGGI------QEVTVNQNLLAPL----NL
QIDPTIQR--VRTEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVRQNL--EPLFE-QYINNLRRQLDGVLG
ERGRLDSELRN-MQDLVEDFKNK-YEDEINKRTT---AENEFVMLK--K---DVDAAYMN
KVELEAKVDALMDEINFLKMFFEA-----ELSQMQTHISDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEDIAN-RSRTEAESWYQTK--YEELQQTAGRHGDDLRSTKHEISEMN--
RMIQRLRAE-I--DNVKK------------------------------------------
-----Q-CA--NLQNAIADAEQ-RGEMAL-KDARNKL----AELEDALQKAKQDMARLLR
EYQELMNTKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VG-PV-------N-ISVVTSNV----------------------------------
------------SSAYGGGG-G--------------FGG--GLGGGLGGG----L-----
-----GGG----------------------------------LG-GGSSS----SYYS--
-----------------------SSGG-----GVGLG--SGLSVGG-------------S
GFSSS---SGRSLGGGFGS---GGGG-SGSSVKFV----STTS-S---------------
------------------------------------------------------------
-------------SRKSFKS----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQSSIS--FQ-SGGRRGFSASSAVTPS-----VGRT-SFSSVS-VSRAGGG-GGG
GYGRIS--------------------------VG-------GAGG-GAGFGSRSLYNVGM
S-KRISMGGG-----G--GFRSG-------------YGF--GG----GAGGGFGGGA-G-
--------------SGFGFG--GGAGGG-------------------------------F
G--GG-AGFGG-GYGGPGFP------VC--PPGGI------QEVTVNQSLLAPL----NL
QIDPTIQR--VKSEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGHK----TVKQNL--EPLFE-SYINNLRRQLESILN
ERGRLDSELRN-MQDTVEDFKNK-YEEEINKRTT---VENEFVILK--K---DVDGAYMN
KVELETKVDGLTDEINFLRALYDM-----ELSQMQVQISDT----NVVLSMDNNRNLDLN
SIIA-EVKAQYEDIAN-HSRTEAESWYQTK--YEELQQTAGRHGDDLRNTKHEISEMN--
RMIQRLRAE-I--DNVKK------------------------------------------
-----Q-CA--NLQAAIADAEQ-RGELAL-KDARAKL----AELEDALQKAKQDMARQLR
EYQELMNVKLSLDIEIATYRKLLEGEE--------------------------C-RLS-G
EG--VG-PV-------N-ISVVTSSV----------------------------------
------------SGGYGSGS-GGFGS----G---GGFGSGGGYG--VGGG----L-----
-----G----------------------------------------GGSG----YSYSS-
-----------------------SS---------GGG--GGLSLGG-------------S
GFSSG---SGRGLGV--SLG--GGGG-SSSSVKFV----STTS-S---------------
------------------------------------------------------------
-------------TRKSFKS----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTQKSYK--VST--SGPRAFSSRSYTSGPG-----ARI-SSSSY-------------
-------------------------------------------------------SRVGS
S----------------------------------SFRGG------------LGGGY---
------------------------------------------------------------
-------------------GGAS-------GMGGI------TAVTVNQSLLSPL----NL
EVDPNIQA--VRT QEKEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQQ-QKT-----ARSNM--DNMFE-SYINNLRRQLETLGQ
EKLKLEAELGN-MQGLVEDFKNK-YEDEINKRTE---MENEFVLIK--K---DVDEAYMN
KVELESRLEGLTDEINFLRQLYEE-----EIRELQSQISDT----SVVLSMDNSRSLDMD
SVIA-EVKAQYEEIAN-RSRAEAESMYQIK--YEELQSLAGKHGDDLRRTKTEISEMN--
RNISRLQAE-I--ESLKG------------------------------------------
-----Q-RA--SLEAAIADAEQ-RGELAI-KDANAKL----SELEAALQRAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEES---------------------------RLE-S
---GM---Q--------NMSIHTKTTSG--------------------------------
---------------YAG---------------------GLSS-----------------
---AYG------------------------------GLTSPGLSYGLG------------
--------------------------------SS---------FGSGA---------GSS
SFSRT-------------------SSSRAVVVKKI------ETRDGKLVSESSDVLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
----------------------------------------------------------MR
-SSVSRQTYST--------KGGFSSNSACGG---GGSRART-SFSSVT-VSRSGGSGGG-
--------------------------A--------------RCGPSLGGFGSRSLYNLGG
S-KSISVSVAGGASSG-RGL----------------------------------------
--------------GGFGLG------------------GGAYV-----------------
-------G---------TGRQAFGP-VC--PPGGI------QEVTVNQSLLTPL----HV
EIDPEIQR--VRTQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQGQNSG--VTRNNL--EPLFE-RYLNSLRRQLDNLQG
ERGKLDSELRS-VQDLVEDFKTX-XXXXXXXXXX---XXXXXXXXX--X---XXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXX-----ELSQVQTHVSDT----NVILSMDNNRCLDLD
SIIA-EVKAQYELIAQ-KSRAEAEAWYHPK--YEELQVTAGKHGDNLRDTKNEISELT--
RTVQRLQGE-V--DAVKK------------------------------------------
-----Q-XX--XXXXXXXXXXX-XXXXXX-XXXXXKL----GDLD-ALHQPKGDLARLLR
DTQALMNVKRALDVEIPTYRKLLEGEE--------------------------S-PMS-G
ECPSA---V--------SISVTGNSTTVCG------------------------------
-----------------GS--------------AGGYGGGMSLGGS---GG--ASKGGFS
SN----------------------------------------VGYGT----------V--
KGGPSSG--GTSILRKT--TTVKTSSRRY-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTQKSYK--VST--SGPRAFSSRSYTSGPG-----ARI-SSSSF-------------
-------------------------------------------------------SRVGS
S----------------------------------SFRGG------------LGGGY---
------------------------------------------------------------
-------------------GGAS-------GMGGI------TAVTVNQSLLSPL----NL
EVDPNIQA--VRT QEKEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQQ-QKT-----ARSNM--DNMFE-SYINNLRRQLETLGQ
EKLKLEAELGN-MQGLVEDFKNK-YEDEINKRTE---MENEFVLIK--K---DVDEAYMN
KVELESRLEGLTDEINFLRQLYEE-----EIRELQSQISDT----SVVLSMDNSRSLDMD
SIIA-EVKAQYEEIAN-RSRAEAESMYQIK--YEELQSLAGKHGDDLRRTKTEISEMN--
RNISRLQAE-I--EGLKG------------------------------------------
-----Q-RA--SLEAAIADAEQ-RGELAI-KDANAKL----SELEAALQRAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEES---------------------------RLE-S
---GM---Q--------NMSIHTKTTSG--------------------------------
---------------YAG---------------------GLSS-----------------
---AYG------------------------------GLTSPGLSYGLG------------
--------------------------------SS---------FGSGA---------GSS
SFSRT-------------------SSSRAVVVKKI------ETRDGKLVSESSDVLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTQKSYQ--VS--TSGPQAFSSCFYTSGPG-----ACI-SSSSL-------------
-------------------------------------------------------SRVGS
-----------------------S-----------SFWGG------------LGG-----
---------------GYG------------------------------------------
-----------------GASG----------IGGI------TAVTFNQSLLSPV----NL
KVDLNIQ-------EKEQIKTLN-KFASF------IDK--IQ----------------------FPEQQNK-MLGTKWSLLQQ-QKT-----AGINM--DNMFE-SYINNLRRHLETLSQEKLKLETELGN-MQGLVEDFKNK-YEDEINKHTE---MENEFVLIK--K---DVDEAYMNKVELESRLEGLTDEISFLRQLFEE-----EIQELQSQISDT----SVVLSMDNSHSLDMDSVIA-EVKAQYKETAH-HSQAEADSMYQIK--NAELQTLAGKHGDDQRCTKTDISEMN--RNISWLQAE-I--EGLKG-----------------------------------------------Q-RA--SLEVTITDAEQ-RGELAV-KDGNAKL----SELEAALQRAKQDMAWQLREYQELMNVKLALDIEIATYRKLLEGEES---------------------------RLE-S---GM---Q--------NISIHMKTTSG-----------------------------------------------YAS---------------------GLSL--------------------AYG------------------------------GLTSPGLSYGLG--------SS----------------------------------S---------G--SVA---------SSSSFSCI-----------SST-----SSTRAMVVKEI------EAHDGKLVSKSSDVLPK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EKEQIKTLN-KFASF------IDK--IQ------------------
----FPEQQNK-MLGTKWSLLQQ-QKT-----AGINM--DNMFE-SYINNLRRHLETLSQ
EKLKLETELGN-MQGLVEDFKNK-YEDEINKHTE---MENEFVLIK--K---DVDEAYMN
KVELESRLEGLTDEISFLRQLFEE-----EIQELQSQISDT----SVVLSMDNSHSLDMD
SVIA-EVKAQYKETAH-HSQAEADSMYQIK--NAELQTLAGKHGDDQRCTKTDISEMN--
RNISWLQAE-I--EGLKG------------------------------------------
-----Q-RA--SLEVTITDAEQ-RGELAV-KDGNAKL----SELEAALQRAKQDMAWQLR
EYQELMNVKLALDIEIATYRKLLEGEES---------------------------RLE-S
---GM---Q--------NISIHMKTTSG--------------------------------
---------------YAS---------------------GLSL-----------------
---AYG------------------------------GLTSPGLSYGLG--------SS--
--------------------------------S---------G--SVA---------SSS
SFSCI-----------SST-----SSTRAMVVKEI------EAHDGKLVSKSSDVLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSIRSTMR--TQ-SSSQRGFSASSARAPG-----GSRS-GFSCVS-VSRSRGTGGAG
G-------------------------------VY-----------GGAGFGSRSLYSLGG
T-KRISIGGG----SC--GLSSG-------------YGS--RV----GGGYGFGGGA-G-
--------------SGFGFG--AG--A------GS-----------------GF----GF
G--GG-AGF-----GGSGFP------VC--PPGGI------QEVTVNQNLLTPL----NL
QIDPTIQR--VRTEEREQIKTLNNKFASF------IDK--VR------------------
----LLEQQNN-ILAMKWALLQGQGTR----TVTQSL--EPLFE-QYINNLRRQLDSILG
DRGHLDSELRS-MQSTVEDYKNX-XXXXXXXXXX---XXXXXXXXX--X---DVDAAYMN
KVELQAKADSLTDEINFLRTLYEA-----ELSQMQTHISDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEEIAQ-RSRAEAESWYQTK--YEELQVSAGRHGDDLRNTKQEISELN--
RMIQRLRSE-I--DHVKK------------------------------------------
-----Q-CA--SLQSAIADAEQ-RGELAI-KDAKNKL----ADLEDALQKAKQDMARLLR
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLN-G
EG--VG-QV-------N-ISVVQSTV----------------------------------
------------SGGYGGASAI--------------------------------------
---------------------------------------GGSSGLGGGSG----YS----
-----------------------YGSG------HSLG--G--------------------
GFSSG---SGRGLG--GGFS--SSGGS-GSTIKYT----TTSS-S---------------
------------------------------------------------------------
------------SSRRSYKN----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--M-SRQSTIT--FHS-GSRRGFSTASATTPN-----AGRS-RFSSVS-VARTSG--NSG
GLGRIG--------------------------GA------------GAGFGSRSLYNLGG
T-KRVSIGGCAGSG-----SRSS-------------FGG--RA----SSGFGV-----S-
--------------SGFGYG--GGIGGAF-------------------------------
--------------GGPGFP------VC--PSGGI------QEVTVNQSLLTPL----NL
QIDPTIQR--VRK EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQEQGSR----TVRQNL--EPFFD-AYLNDLRRQLDGVAA
ERGRLDAELRS-MQEVVEDFKVR-YEDEINKRAA---AENEFVGLK--K---DVDGAYMS
KVELEAKVDSLTDQINFYRMIYEA-----ELSQMQNQVSDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEEIAN-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEISEMN--
RMIQRLRSE-I--DAVKK------------------------------------------
-----Q-CT--SLQTAISDAEQ-RGELAL-KDARAKL----VDLEDALQKAKQDMARLLR
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VS-PVNIS--------VVTSTV----------------------------------
------------SSGYGGGS--NIG-----------------------------------
---------------------------------------GGSLGLGGNSV----YSFTT-
-----------------------SG-------GHSLG--S--GLGG-------------S
GFTTS---SSRGPVG------------SGSSVKFV----STTS-----------------
------------------------------------------------------------
------------SSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R-V-TQKSYK--VST--SGPQAFSSLSYTSGPA-----SRI-SSSSF-------------
-------------------------------------------------------SRMGS
S----------------------G-----------SFWGG------------MGL-----
------------------------------------------------------------
---------------GGY-GGAG-------GVGSI------TAVQVNQSLLNPL----NL
EVDPNIQA--VRI QEKEQIKNLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQQ-QKT-----SRSNM--DNMFE-SYINNLRRQLDSLGQ
EKMKLEAELGN-MQGLVEDFKNK-YEDEINKRTE---MENEFVLIE--K---DVDEAYMN
KVELESRLEGLTDEINFLRQLYEE-----EIRELQSQISDT----SVVLSMDNSRSLDLD
GIIT-KVKAQYEEIAN-RSRAEAESMYQIK--YEELQTLAGKHGDDLRRTKTEISEIT--
RSISRLQAE-I--EALKG------------------------------------------
-----Q-RA--SLEAAIADAKQ-RGEMAI-KDANAKL----AQLEAALQKAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEEN---------------------------RLE-A
---GM---Q--------NLSIHTKTTSG--------------------------------
---------------YSG---------------------MVSS-----------------
---PYG------------------------------GLTSPGFASIQS------------
---------------------------------P--------------------------
GF--T-------------------RTKSAVVVKKI------ETCDGKLVSETSLGCPAQV
S-GPQQP--LQ----PAPLTRPPQSPWGDSCTREH-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSSKSTVR--TH-SSSRRGFSAGSARLPG-----VSRS-GFSSVS-MSRSRGS-GLG
G-------------------------------VC-----------GGAGFGSRSLYGLGS
S-QRISIGGG----SC--AVGGG-------------YGG--RV----GSGFGLGGG----
----------------FGFG--GG--A------GA-----------------GF----GL
G--GG-AGFAG-GYGGPGFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPTIQR--VRT EEREQIKTLNNKFASF------IDK--VC------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVRQSL--EPLFE-QYINNLRRQLDSILG
ERGRLDTELRA-MQDTVEDFKNK-YEDEINKRTA---AENEFVTLK--K---DVDAAYMN
KVELQAKADSLTDEINFLRAFYDA-----ELSQMQTHISDT----SVVLSMDNNRSLDLD
SIIA-EVKSQYEAIAQ-RSRDEAESWYQTK--YEELQVTAGRHGDDLRNTKQEIAEIN--
RMIQRLRSE-I--DHVKK------------------------------------------
-----Q-CA--NLQAAIADAEQ-RGEMAL-KDAKGKL----EGLEDALQKAKQDMARLLK
DYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLN-G
EG--VG-PV-------N-ISVTQSTI----------------------------------
------------SSGYGGSSG-------------------------V-------------
---------------------------------------SGGLGLGGGSG----YS----
-----------------------YGSG--------------QGLG--------------G
GFSSS---SGRGMG--GGLS--SMGGS----IKYT----TTSS-S---------------
------------------------------------------------------------
--------------RKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
----------------------------MNGVSWSQDL-QEGISSWFGPSASTPASTMSI
R--VTQKSYK--VS-----------RSYTSGPG-----ARI-SSSSV-------------
-------------------------------------------------------LPS-G
K---------------------QS-----------AFRGG------------LGGSY---
--------------GG--------------------------------------------
-------------------ASAW---------EGI------TAVHGQPG-----------
---ALLSP--LNWRRRSRSKSLNNKFCLLHRQGEGPPC--VR------------------
----FLEQQNK-MLETKWSLLQQ-QKT-----ARSNM--DNMFE-SYINNLRRQLETLGQ
EKLKLEAELGN-MQGLVEDFKNK-YEDEINKRTE---MENEFVLIK--K---DVDEAYMN
KVELESRLEGLTDEINFLRQLYEE-----EIRELQSQISDT----SVVLSMDNSRSLDMD
SVIA-EVKAQYEEIAN-RSRAEAESMYQIK--YEELQSLAGKHGDDLRRTKTEISEMN--
RNISRLQAE-I--ESLKG------------------------------------------
-----Q-RA--SLEAAIADAEQ-RGELAI-KDANAKL----SELEAALQRAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEES---------------------------RLE-S
---GM---Q--------NMSIHTKTTSG--------------------------------
---------------YAG---------------------GLTS-----------------
---AYG------------------------------GLTSPGLSYGLG------------
---------------------------------S--------SFGSGA---------GSS
SFSRT-------------------SSSRAVVVKKI------ETRDGKLVSESSDVLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MISRQQGVR-----S-GSRGFSVGSAIVGGG----KKS--AFSSAS---VAGGA----
-----------------------------------------GRCS-SGGFGSRSLYNLGG
N-KSISMSMAGFRQ-GA-GFGAAGG-----------------------------------
------------------------------------FGAGGFG-----------------
---GGLGG----AFN--GRGGPGFP-VC--PAGGI------QEVTINQSLLTPL----HV
EIDPEIQK--VRTEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQQQTTTT----SSKNL--DPFFE-TYISVLRKQLDSLVN
DKGRLQSELKL-MQDSVEDFKTX-XXXXXXXXXX---XXXXXXXXX--X---DVDAAYMT
KVELEAKVDGLNDEVNFLRALYAA-----ELAQMQTHVSDT----SVVLSMDNNRCLDLD
SIIA-EVRAQYEEIAQ-KSKLEAESLYQTK--VQQLQTSVDQHGDSLKNTKSEIAELN--
RMIQRLRAE-I--ENVKK------------------------------------------
-----Q-CQ--TLQASVADAEQ-RGELAL-KDAYSKR----TELEAALQKAKEELARLLR
DYQALMNVKMALDVEIATYRKLLEGEE--------------------------C-RIS-G
ECQSS---S--------IM-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
H-------------F---SSPVFTSRSAAFSGR----GAQV-RLSSA----RPGG-----
----------------------------------------------LG-S--SSLYGLG-
------------AS-RPRVAV--RS-----------------------------------
---------------AYG------------------------------------------
----------------G-------P-----VGAGI------REVTINQSLLAPL----RL
DADPSLQR--VRQ EESEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-LLETKWTLLQEQKSA-----KSSRL--PDIFE-AQIAGLRGQLEALQV
DGGRLEAELRS-MQDVVEDFKNK-YEDEINHRTA---AENEFVVLK--K---DVDAAYMS
KVELEAKVDALNDEINFLRTLNET-----ELTELQSQISDT----SVVLSMDNSRSLDLD
GIIA-EVKAQYEEMAK-CSRAEAEAWYQTK--FETLQAQAGKHGDDLRNTRNEISEMN--
RAIQRLQAE-I--DNIKN------------------------------------------
-----Q-RA--KLEAAIAEAEE-RGELAL-KDARAKQ----EELEAALQRGKQDMARQLR
EYQELMSVKLALDIEIATYRKLLEGEE--------------------------S-RLA-G
D-------G--------VGA-----VN---------------------------------
-ISVMNST-GG-----SSSG----------------GGIGLTLGG-----TMGSNALSFS
SS-----AGPGL------------------------------------------------
--------LKAYSIRTASASRRSARD----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------VR------------------
----FLEQQNK-VLETKWELLQQQGGQSK--TGTNNL--EPFFQ-TYISSLQSHLSGLLS
EKGRLEGELTS-MEELVEDFKKK-YEDEINKRTA---AENEFVVLK--K---DVDAAYMT
KVELEAKVESLSDEVNFLKALYDA-----HLCRL--YIRDT----SVVLSMDNNRFLDLD
SIIA-EVKAQYEEIAQ-RSKAEAEALYKTK--LGELESTAGRHGDDLKSTKSEISELN--
RMIQRLRAE-I--ESVKK------------------------------------------
-----Q-NT--NLQTAIADAEQ-RGELAL-KDANAKL----VELKAALQQAKDDLARLLR
DYQELMSVKLSLDIEIATYRTLLEGEEYR-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MNRQVCKK--SF-SGGSQGFSGRSAVVS-S-----SSR-M-SC---VARFRGA-G--
-----GG-------------------------ACGFR----SGA---GGFGSRSLYNPGG
N-KSISVSVAAGGS-RAGGFVGGQS------SCG--FAGGYGGG----FGGSYGGGFGGG
--R--GIGSGFG-------------------------------GAGGFGGAGGLGGPGGF
GGLGSFGSPG--GFV----S------GG--FPGGI------QEVTVNQSLLQPL----NV
EIDPQIGQ--VKAQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWELLQQQTTG----SGPSSL--EPCFE-SYINFLRKQLDSLLA
ERGNLEGELKS-MQDLVEDFKKK-YEDEINKRTA---AENEFVGLK--K---DVDAAFMN
KVELQAKVDSLTDEVSFLRTLYEM-----ELSQMQSHVSDT----SVVLSMDNNRCLDLD
NIIA-EVRAQYEEIAQ-RSKAEAEALYQTK--LGELQTTAGRHGDDLKNTKSEIMELN--
RMIQRLRAE-I--ENVKK------------------------------------------
-----Q-NA--NLQTAISEAEQ-RGEMAL-KDANAKL----QDLQAALQKAKDDLARLLR
DYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RMS-G
ECQSA---V--------CISVVSNVTST--------------------------------
---------SGSSGSSGGVFGGVSG------S--GGYRGGGSSSG---------Y-----
--------------GVSGGSSSA-YGAVSG---------GSSSSYGGVSS-RS---TG--
GR-GSSGGYQ--------------------SSSS------GSRLGGAGSIS---MSHSGM
GSSSG--SV-QTSGGSGYKS----GGGGSTSIRFS----QTT------------------
------------------------------------------------------------
----------SSS-QHNSTK----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

-----------------------------------------------------MNGVSWS
------------------------------------QDLQEGISSWFGPSASTPASTMSI
R--VTQKSYK--VST--SGPRAFSSRSYTSGPG-----ARI-SSSSY-------------
-------------------------------------------------------SRVGS
S----------------------------------SFRGG------------LGGGY---
------------------------------------------------------------
-------------------GGAS-------GMGGI------TAVTVNQSLLSPL----NL
EVDPNIQA--VRT QEKEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQQ-QKT-----ARSNM--DNMFE-SYINNLRRQLETLGQ
EKLKLEAELGN-MQGLVEDFKNK-YEDEINKRTE---MENEFVLIK--K---DVDEAYMN
KVELESRLEGLTDEINFLRQLYEE-----EIRELQSQISDT----SVVLSMDNSRSLDMD
SVIA-EVKAQYEEIAN-RSRAEAESMYQIK--YEELQSLAGKHGDDLRRTKTEISEMN--
RNISRLQAE-I--ESLKG------------------------------------------
-----Q-RA--SLEAAIADAEQ-RGELAI-KDANAKL----SELEAALQRAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEES---------------------------RLE-S
---GM---Q--------NMSIHTKTTSG--------------------------------
---------------YAG---------------------GLTS-----------------
---AYG------------------------------GLTSPGLSYGLG------------
--------------------------------SS---------FGSGA---------GSS
SFSRT-------------------SSSRAVVVKKI------ETRDGKLVSESSDVLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

-----------------------------------------------------MNGVNWS
------------------------------------QDLQEGISSWFGPPASTPASTMSI
R--VTQKSYK--VST--SGPRAFSSRSYTSGPG-----ARI-SSSSF-------------
-------------------------------------------------------SRVGS
S----------------------------------SFRGG------------LGGRY---
------------------------------------------------------------
-------------------GGAS-------RMGGI------TAVTVNQSLLSPL----NL
EVDPNIQA--VRT QEKEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQQ-QKT-----ARSNM--DNMFE-SYINNLRRQLETLGQ
EKLKLEAELGN-MQGLVEDFKNK-YEDEINKRTE---MENEFVLIK--K---DVDEAYMN
KVELESRLEGLTDEINFLRQLYEE-----EIRELQSQISDT----SVVLSMDNSRSLDMD
SIIA-EVKAQYEEIAN-RSRAEAESMYQIK--YEELQSLAGKHGDDLRRTKTEISEMN--
RNISRLQAE-I--EGLKG------------------------------------------
-----Q-RA--SLEAAIADAEQ-RGELAI-KDANAKL----SELEAALQRAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEES---------------------------RLE-S
---GM---Q--------NMSIHTKTTSG--------------------------------
---------------YAG---------------------GLSS-----------------
---AYG------------------------------GLTSPGLSYGLG------------
--------------------------------SS---------FGSGA---------GSS
SFSRT-------------------SSSRAVVVKKI------ETRDGKLVSESSDVLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------FCTLGQVQPTASTPASTPASTMSI
R--VTQKSYK--MSS--SGPRAFSSRSYTSGPG-----SRI-SSSTF-------------
-------------------------------------------------------SRVGG
S--------------------G-S-----------SFRGG------------LSSSM---
--------------SV---V----------------------------------------
---------------GGY-GGAG-------APGGI------TAVSVNQSLLSPL----KL
EVDPNIQA--VRTQEKEQIKTLNNKFANF------IDK--VR------------------
----HLEQQNK-ILETKWGLLQQ-QKT-----ARSNI--DNMFE-SYINNLRRQLDTLGQ
EKLKLEVELGN-MQGLVEDFKNK-YEEEIKERAD---MENEFVLIK--K---DVDEAYMN
KVELESRLEGLTDEINFLRQLYEE-----EIRELQSQISDT----SVVLSMDNSHCLDLD
GIIA-EVKAQYEDIAN-RSRAEAEAMYQIK--YEELQTLAGKHGDDLRRTKTEISEMN--
RSISRLQAE-I--EALKN------------------------------------------
-----Q-RA--ALEAAIADAEQ-RGELAI-KDANAKV----AELEAALQRAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEES---------------------------RLE-S
---GM---Q--------NMSIHTKTTSG--------------------------------
---------------YSG---------------------GLSS-----------------
---AYG------------------------------GLTSPGLNYGLSSF-------Q--
--------------------------------SS---------FGPAG------------
SFSRS-------------------SSSKAVVVKKI------ETRDGKLVSESSDVLSK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------GASS----------KGGI------TAVTVNQSLLSPL----NL
QVDPNIQA--MCTQEKEQIKTLNNKFASF------IDK--VW------------------
----LLEQQNK-MLETKWSLLQQ-QKM-----TLSNM--DSMLQ-SYINNLQRQLETLGQ
GKLKLEAELGS-MQGLVEGFKNK-YKDKINKRTE---MENEFVLIK--K---VVDDAYMN
TVELESHLEGLTDEIHFLRQLYEE-----EIRELS--ILDT----SVVLSMDNSCSLDMD
SIIT-EVKAQYEEIAN-AARPR--LRACTR--SNEELMLAGKHEDDLCHTKMEISEMN--
WNISWLQAE-R--EGLKG------------------------------------------
-----Q-RA--SLEATITDAEQ-HGELAV-KNANTKL----YELGPTLQWAEQDMVQQLH
ECQELMKS-------------LALDIEI---------------------------YTS-C
SC----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

MTSVGVF---------SDMLSRSEKDGPVPKAKPRDVSDFSLYALATKPCCS--------
------------------------STYKRPGPGLRHS-PAWPL----SRFSDNSELTLLS
PAMIARQQCVR-----G-GSRGFSCGSAV-VGG----GKRA-AFSSVS---VSGGA----
-----------------------------------------GRCS-SGGFGSRSLYNLGG
N-KSISISVAGAQQ-GA-GFGGAAG-----------FG----------------------
-------------AGGFG----------------AGFGAGSYG-----------------
---GGFGS----SFS--ARGGAGFP-VC--PAGGI------QEVTINQSLLTPL----HV
EIDPEIQK--VRTEEREQIKILNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWKLLQQQTTTT----SSKNL--EPFFE-AYLSALRKQVDTLAN
DKGRLQSELKT-MQDSVEDFKTR-YEEEINKRTA---AENDFVVLK--K---DVDAAYMN
KVELEAKVDALNDEINFLRALYAA-----ELSQMQSHVSDT----SVVLSMDNNRDLDLD
SIIA-EVRAQYEEIAQ-RSKAEAEALYQIK--VQQLQTSVDLHGDNLKNTKNEISELN--
RLIQRLRAE-I--ENVKK------------------------------------------
-----Q-CQ--TLQASVADAEQ-RGELAL-KDAHSKR----TELEAALQKAKEELARMLR
EYQDLLSVKLALDIEIATYRKLLEGEE--------------------------Y-RMS-G
ECQSA---V--------SISVVSGATSAGG------------------------------
---------------IG-GG---FGA----S---SGFG--LGS-----------------
---------------------------------GFGSG--SGSGSGF--G-FG-------
----VGGSSSSKTISSTTLTKR--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
-FTMNRQVCKT--S--GGGSHGFSGRSAVVSG------SSR-M-SC---VARTGRS-G--
-----GG-------------------------ACGAR----SG---AGGFGSQSLYNLGG
N-RSISYSVAGGSRGGAFGFGGGRS------SCGGGFGGAG----------GFGGGFG--
--------------GGFG--------------G-------GFGGAGGFGGAAGYGGLGGF
GGPGGFGGPG-----G---PGGFGP-GG--FPGGI------QEVTVNQSLLQPL----NV
EIDPQIGA--VRSQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQQQGVNSV--TGTNNL--DPLFE-SYISNLRRTLDGLQG
ERGKLDGELRS-MQELVEDFKRK-YEDEINKRTA---AENEFVTLK--K---DVDAAYMN
KVELQSRVDSLVDEVNFIRALYEA-----ELNQMQTHVSDT----SVILSMDNNRSLDLN
SIIV-EVQAQYEEMVE-RSKAEANELYQTK--LGELQTKAGRHGDDLKSTKSEIMELN--
RMIQRLRAE-I--ENIKK------------------------------------------
-----Q-NV--NLQAAIAEAEQ-RGELAL-KDAQAKL----QGLQTALQQAKDDLARLLR
DYQDLMNVKLALDVEIATYRKLLEGEE--------------------------Y-RMS-G
EFQNP---V--------SISVVSSSTS---------------------------------
--------TSVSGGGYGGG-YGGG------------------------------------
-----------------------------R---------AGGSGFGGGSG----------
------------F-----------------------------GGGSG-------------
--------R-SGVSRGGISS----GSTLGGSSSSS----SSS------------------
------------------------------------------------------------
----------VKY-SQSSGQRSSSYMH---------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
----------------------------------------------------------MR
-SSMSRQTYAT--------KGGFSSNSASGG---SGCRTHT-SFSSVT-MSRSGGTGSG-
--------------------------V--------------HRGPSTGGFGSRSLYNLGG
S-KSISVSVA---SSG-RAL----------------------------------------
--------------GGFGHS------------------SGAYG-----------------
-------SLG-------AGRQTFGP-VC--PPGGI------QEVTINQNLLTPL----NV
EIDPEIQR--VRT QEREQIKILNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEEGQNMG--VTKLNP--EPLFE-GYLNNLRRILDRHLD
ERGRLDTELRN-VQDGLEDFKNK-YEDEINKRTA---LENEFVVLK--K---DVDAAYMA
KMDLQGRVDALVQEIDFLQQFYEM-----ERSQAQTHVSDT----NVILSMDNNRNLDLD
SIIA-EVKAQYELIAQ-RSRAEAEAWYQTK--YEELQVTAGKHGDNLRDTKNEIAELT--
RTIQRLQSE-V--DSAKK------------------------------------------
-----Q-CQ--QLQAAIAEAEE-RGELAL-KDAKKKL----GDLDAALHQAKEDLARLLR
DYQDLMNVKLALDVEIATYRKLLESEE--------------------------S-RMS-G
DCPSA---V--------SISVTGNSTTVRG------------------------------
-----------------GG--------------SAGFGGGISLGGG---GG--VSKGGFS
TS----------------------------------------VGFST----------V--
KGGPVSG--GTSILRKT--TTVKTSSRRY-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------M--
----NRQVCKT--S--GGGSQGFSGRSAVVSG------SSR-M-SC---VARSGGT-G--
-----GG-------------------------ACGFR----AG---AGGFGSRSLYSLGG
N-KSISISVAG-GS-RAGGFGGGRS------S--CG------SGFGGGYGGGFGGGFGGG
--R--GMGGGFGGAGGLG--------GAGGFGGA-----GGLGGLGGFGGVGGFGGAGGL
GGAGGFGGPG--GFGG---PGGFGP-GG--FPGGI------QEVTINQSLLQPL----NV
EIDPQIGQ--VKTQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQQQGTNSM--TGTNNL--EPLFE-TYISNQRSYLDSILG
ERGRLDSELRN-MQDLVEDFKKK-YEDEINKRTA---AENEFVTLK--K---DVDAAYMN
KVELQAKVDALMDEINFLTNLYDM-----ELSQMQSHVSDT----SVVLSMDNNRFLDLD
SIIA-EVKAQYEEIAQ-RSKAEAEALYQTK--LGELQTTAGRHGDDLKSTKSEIMELN--
RMLQRLRAE-I--ENVKK------------------------------------------
-----Q-NA--NLQAAIAEAEQ-RGELAL-KDANAKL----QELQAALQQAKDDLARLLK
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RMS-G
ECQSA---V--------SISVVSSGG----------------------------------
-------ATSGSAGGLGGGFGG-------------GFGAGGGAGG---------------
--------------------FG----GGRS---------SCGSGFGGGFG--GGFGGG--
YGGGYGGGFGGGR----------GMGGGFGG---------AGGLGG-AGG--F-GGAGGF
GGP------------GGFGL----NS-------------HSS------------------
------------------------------------------------------------
----------QLK-KK--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------M--
----SRQASKT--S--GGGSQGFSGRSAVVSG------SSR-M-SC---VTRSGVA-G--
-----GG-------------------------AYGFR----SG---AGGFGSRSLYNLGG
N-KSISISVAAGGS-RAGGFGGGRS------S--CGFAGGYGGGFGGGYGGGFGGGFGGV
--R--GMGGGFGGAGGFG--------GAGGFGGA-----SGFGGPGGFGGPGGFGGPGSF
GSPGGF---------G---P------GG--FPGGI------QEVTINQSLLQPL----NV
EIDPQIGQ--VKA QEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQQQSTSSI--SGTNNL--EPLFE-NHINYLRSYLDNILG
ERGRLDSEMRN-MQDLVEDFKKK-YEDEINKRTA---AENEFVTLK--K---DVDGAYMN
KVELQAKVDALIDEINFLRTLYDA-----ELSQMQSHISDT----SVVLSMDNNRSLDLD
SIIA-EVRAQYEDIAQ-RSKAEAEALYQTK--LGELQTTAGRHGDDLRNTKSEIIELN--
RMIQRLRAE-I--ESIKK------------------------------------------
-----Q-NA--NLQTAIVEAEQ-RGEMAL-KDANAKL----QELQAALQQAKDDLARLLR
DYQELMNVKLALDVEIATYRKLLEGEE--------------------------Y-RMS-G
ECPSA---V--------SISVVSSST----------------------------------
--------TSASAGGYAGGYGG-------------GVGGGLGGGL---------------
--------------------GA----GGG-----------SSSGFGRGGG--GGIGG---
---GFGG------------------GS--------------------SGG--F-SGGSGF
GSSSG--AR-YGVSGGGFSS----ASNRGGSIKFS----QSS------------------
------------------------------------------------------------
----------QSS-QRYSR-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--M-SRQSTIT--FHS-GSRRGFSTASATTPT-----AGRS-RFSSVS-VARSSG--NSG
GLGRIS--------------------------GA-------G---AGAGFGSRSLYNLGG
T-KRVSIGGCAGSG-----FRSS-------------FGG--RA----SSGFGV-----S-
--------------SGFGYG--GGIGGAF-------------------------------
--------------GGPGFP------VC--PSGGI------QEVTVNQSLLTPL----NL
QIDPTIQR--VRK EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQEQGSR----TVRQNL--EPFFD-AYLNDLRRQLDGVTA
ERGRLDAELRS-MQEVVEDFKVR-YEDEINKRAA---AENEFVGLK--K---DVDGAYMS
KVELEAKVDSLTDQINFYRMIYEA-----ELSQMQNQVSDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEDIAN-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEISEVN--
RMIQRLRSE-I--DAVKK------------------------------------------
-----Q-CS--SLQTAISDAEQ-RGELAL-KDARAKL----VDLEDALQKAKQDMARLLR
EYQELMNVKLSLDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VS-PVNIS--------VVTSTL----------------------------------
------------SSGYGGGS--NIG-----------------------------------
---------------------------------------GGSLGLGGSSG----YSFTT-
-----------------------SG-------GHSLG--S--GLGG-------------S
GFTTS---SNRGLVG------------SGSSVKFV----STTS-----------------
------------------------------------------------------------
------------SSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------MSIHFSSRSTAFPGR----GAQM-RLSSG----RAGG-----
----------------------------------------------FGS---SSFYGLS-
------------TS-RPRVAV--RS-----------------------------------
---------------AYG------------------------------------------
----------------N-------P-----VGAGI------REITINQSLLAPL----RV
DIDPTIQQ--VRQ EEHEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWALLQDQKSA-----KGSQL--PRIFE-AQIAGLRQQLEALQL
DGGRLEVELQS-VQDVVEDFKNK-YEEEINRRTA---AENEFVLLK--K---DVDAAYMN
KVELEAKVDSLNDEISFLKALNET-----ELAELQSQISDT----SVVLSMDNNRSLDLD
SIIA-DVKAQYEEMAN-HSRAEAEAWYQTK--FETLQAQAGKHGDDLRNTRNEIAEMN--
RSIQRLQAE-I--DNAKN------------------------------------------
-----Q-RA--KLEASVAEAEE-RGELAL-KDAHAKQ----EELEAALQQAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEE--------------------------S-RLS-G
DGVGP---V--------NISL---------------------------------------
----VNS----------TGG----------------SSNRLNFGG-----TMGSNALSFS
SS-----GGPGG------------------------------------------------
--------LKAYSVRTTSTTRRGPHN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTQKSYQ--VST--SGPQAFSSCFYTSGPG-----ACI-SSSSL-------------
-------------------------------------------------------SRVGS
S----------------------------------SFWGG------------LGGGY---
--------------G---------------------------------------------
------------------GASS---------IGGI------TAVTFNQSLLSPV----NL
KVDLNIQ A--MHT QEKEQIKTL-NKFASF------IDK--IQ------------------
----FPEQQNK-MLGTKWSLLQQ-QKT-----AGINM--DNMFE-SYINNLRRHLETLSQ
EKLKLETELGN-MQGLVEDFKNK-YEDEINKRTE---MENEFVLIK--K---DVDEAYMN
KVELESRLEGLTDEISFLRQLFEE-----EIQELQSQISDT----SVVLSMDNSHSLDMD
SIIA-EVKAQYKETAH-HSQAEADSMYQIK--NAELQTLAGKHGDDQRCTKTDISEMN--
RNISRLQAE-I--EGLKG------------------------------------------
-----Q-RA--SLEVTITDAEQ-RGELAI-KDGNAKL----SELEAALQRAKQDMAWQLR
EYQELMNVKLALDIEIATYRKLLEGEES---------------------------RLE-S
---GM---Q--------NVSIHMKTTSG--------------------------------
---------------YAS---------------------GLNL-----------------
---AYG------------------------------GLTSPGSSSGSV--------AS--
--------------------------------SS--------SFS---------------
CISST-------------------SSTRAMVVKEI------ETRDGKLVSKSSDVLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTQKSYK--MST--SSPRAFSSRSYTSGPS-----SRI-SSSAF-------------
-------------------------------------------------------SRVGS
S--------------------S-G-----------SFRGG------------LNSSM---
--------------SV---V----------------------------------------
---------------GGY-GGPG-------VVGSI------TAVSVNQSLLNPL----KL
EVDPNIQA--VRTQEKEQIKSLNNKFASF------IDK--VR------------------
----HLEQQNK-ILETKWSLLQQ-QKT-----SRSNI--DNMFE-SYINNLRRQLDTLGQ
EKLKLEVELGN-MQGLVEDFKNK-YEDEIKLRGD---MENEFVLIK--K---DVDEAYMN
KIELESRLEGLTDEINFLRQLYEE-----EIHELQSQISDT----SVVLSMDNSRSLDLD
GIIA-EVKAQYEDIAN-RSRVEAETMYQIK--YEELQTLAGKHGDDLRRTKTEISEMN--
RSISRLQAE-I--ETLKN------------------------------------------
-----Q-RA--ALEAAIADAEQ-RGELAV-KDANAKV----AELEAALQRAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEESR-------------------------DRLE-S
---GM---Q--------NMSIHTKTTSG--------------------------------
---------------YSG---------------------GLNL-----------------
---AYG------------------------------GLTSPGLNYGQSSF-------Q--
--------------------------------SG---------FGPGG------------
SFSRS-------------------SSSKAVVVKKI------ETRDGKLVSESSDVLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSM
H-------------F---SSRAFSSRSAAAPGR----GAQV-RLTSG----RRGG-----
----------------------------------------------FG-S--SSLYGLG-
------------TS-RPRVAV--HS-----------------------------------
---------------AYA------------------------------------------
----------------G-------P-----LGAGI------HEVTINQSLLAPL----QV
DIDPSIQQ--VRQ EEREQIKTLNDKFASF------IDK--VR------------------
----FLEQQNK-LLETKWALLQEQKST-----KSSRL--PGVFE-AQIAGLRGQLEALQV
DGGRLEVELRS-MQDVVEDFKNK-YQDEINHRTA---AENEFVVLK--K---DVDAAYMN
KVELEAKVDALNDEINFLKTLHET-----ELTELQSQNLDT----SVVLSMDNSRSLDLD
GIIA-EVKAQYEEMAH-RSRAEAEAWYQTK--FETLQAQAGKHGDDLRNTQKEIADMN--
RAIQRLQAE-I--DNIKN------------------------------------------
-----Q-RA--RLEAAIAEAED-RGELAL-KDARVKQ----EELEAALQRAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEE--------------------------S-RLA-G
DGAGA---V--------NISV---------------------------------------
----VKS---------TGG-----------------GGSGLAFGG-----TMGSNALRFS
SS-----AGPGA------------------------------------------------
--------LQAYSARTASTSRRSARN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSCRSTVK--TQ-SISRRGFSAGSARLPG-----VCRS-GFSSVS-LSRSRGSGGLA
G-------------------------------VC-----------GGAGFGSRSLYGLGG
S-KRISIAGG----SC--VIGGG-------------YGG--RI----GVGYGFGGGA-G-
--------------SGIGFG--AG--A------GS-----------------GF----GL
G--GG-AGFGG-GYGGYGFP------VI--PPGGI------QEVTVNQSLLTPL----NL
QIDPTIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTR----TVRQNL--EPLFE-QYINNLRRQLDSILG
ERGRLDSELRG-MQDTVEDFKNK-YEDEINKRTA---AENEFVKLK--K---DVDSAYMN
KVELQAKVDALTDEINFLRTFYDA-----ELAQMQSYISDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEEIAQ-RSRAEAESWYQSK--YEELRVTAGRHGDDLRNTKQEISEIN--
RVIQRLRSE-I--DHVKK------------------------------------------
-----Q-CA--SLQSAIADAEQ-RGELAL-KDARNKL----ADLEDALQKAKQDMARLLK
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--AG-QV-------N-ISVVQSTV----------------------------------
------------SSGYG-----------------------G--ASGL-------------
---------------------------------------SSGLGIGGGSG----CS----
-----------------------YS----------IG--G--------------------
GFSSG---SGRAIG--GGYG--SSGGS-SSTIKYT----TSS--C---------------
------------------------------------------------------------
------------SSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
----------------------------------------------------------MR
-SSVSRQTYST--------KGGFSSNSASGG---SGSQART-SFSSVT-VSRSSGSGGG-
--------------------------A--------------RCGPGTGGFGSRSLYNLGG
H-KSISVSVARGASSG-RAL----------------------------------------
--------------GGFGFG------------------SRAFM-----------------
-------GQG-------AGRQTFGP-AC--PPGGI------QEVTVNQSLLTPL----HV
EIDPEIQR--VRTQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQGQNLG--VTRNNL--EPLFE-AYLGSMRSTLDRLQS
ERGRLDSELRN-VQDLVEDFKIK-YEDEINKRTA---AENEFVVLK--K---DVDAAYMG
RMDLHGKVGTLTQEIDFLQQLYEM-----ELSQVQTHVSNT----NVVLSMDNNRNLDLD
SIVA-EVKAQYELIAQ-RSRAEAEAWYQTK--YEELQVTAGKHGDNLRDTKNEIAELT--
RTIQRLQGE-A--DAAKK------------------------------------------
-----Q-CQ--QLQTAIAEAEQ-RGELAL-KDAQKKL----GDLDVALHQAKEDLTRLLR
DYQELMNVKLALDVEIATYRKLLESEE--------------------------S-RMS-G
ECPSA---V--------SISVTGNSTTVCG------------------------------
-----------------GG--------------TASFGGGISLGGS---GG--ATKGGFS
TN----------------------------------------VGYST----------V--
KGWPVSG--GTSILRKT--TTVKTSSQRY-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTQKSYK--VST--SGPRTFSSRSYTSGPG-----ARI-SSSSF-------------
-------------------------------------------------------SRVGS
S----------------------------------SFRGG------------LGGGY---
--------------G---------------------------------------------
------------------GASG---------MGGI------TAVTVNQSLLSPL----NL
EVDPNIQA--VRTQEKEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQQ-QKT-----ARSNM--DNMFE-SYINNLRRQLETLGQ
EKLKLEAELGN-MQGLGGGL-----QKQINKRTE---MENEFVPIK--K-----------
-------------DINFLRQLYEE-----EIRELQSQISDT----SVVLSMDNSRSLDMD
SIIS-EVKAQYEEIAN-RSLAEAESMYQTK--YEELQSLAGKHGGDLRRTKTEISEMN--
RNISRLQAE-I--EGLKG------------------------------------------
-----Q-RA--SLEATIADAEQ-RGELGI-KDANAKL----SELEAALQRAKQDMARQLR
EYQELMNVKLALDIESATYRKLLEGEES---------------------------RLE-T
---GM---Q--------NMSIHTKTTSG--------------------------------
---------------SGG---------------------GLSL-----------------
---AYG------------------------------VFTSPGLSYSLG------------
---------------------------------S--------SFGSGA---------GSS
SFSST-------------------SSSRAMVVKKI------ETCDGKLVSESSDVLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
----------------------------------------------------------MR
-SSVSRQTYYT--------KGGFSSNSASGG---GGSQART-SFSSVT-VSRNSGSGGG-
--------------------------A--------------RCGPSTGGFGSRSLYNLGG
H-KSISVSVAGGASSG-WAL----------------------------------------
--------------GGFGFG------------------SRAFT-----------------
-------GQG-------AGRQTFGP-AC--PPGGI------QEVTVNQSLLTPL----HV
EIDPEIQR--VRTQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQGQNLG--VTRNNL--EPLFE-AYLGSMRSTLDRLQS
ERGRLDSELRN-VQDLVEDFKNK-YEDEINKRTA---VENEFVVLK--K---DVDAAYMG
RMDLHGKVGTLIQEIDFLQQLYEM-----ELSQVQTHVSDT----NVVLSMDNNRNLDLD
SIIA-EVKAQYELIAQ-RSRAEAEAWYQTK--YEELQVTAGKHGDNLRDTKNEIAELT--
RTIQRLQGE-V--DAAKK------------------------------------------
-----Q-CQ--QLQTAIGEAEH-RGELAL-KDAQKKL----GDLDVALHQAKEELARLLR
DYQELMNVKLALDVEIATYRKLLESEE--------------------------S-RMS-G
ECPSA---V--------SISVTGNSTTVCG------------------------------
-----------------G---------------------GIALGGN---GG--ATKGGFS
TN----------------------------------------VGYST----------V--
KGGPVSG--GTSILRKT--TTVKTSSRRY-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTQKSYK--VSS--SGPRGFSSLSFTSAPG-----SRI-SSA-L-------------
-------------------------------------------------------SRV-G
S--------------------G-S-----------SFRGG------------LGSSM---
--------------SV---V----------------------------------------
---------------GGY-GRPG-------GMGAI------TAVSVNQSLLSPL----KL
EVDPNIQA--VRT QEKEQIKTLNNRFASF------IDK--VR------------------
----HLEQQNK-ILETKWNLLQQ-QKT-----ARSNM--DNMFE-SYINNLRRQLDTLGQ
EKLKLEVELGN-MQGLVEDFKNK-YEEEIKERAD---MENEFVLIK--K---DVDEAYMN
KVELESRLEGLTDEINFLRQLYEE-----EIRELQSQISDT----SVVLSMDNSRSLDLD
GIIA-EVKAQYEEIAN-RSRAEAETMYQIK--YEELQTLAGKHGDDLRRTKTEISEMN--
RNINRLQAE-I--EGLKN------------------------------------------
-----Q-RA--SLEAAVADAEQ-RGELAV-KDANAKV----AELEAALQRAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEES---------------------------RLE-S
---GM---Q--------NMSIHTKTSTG--------------------------------
---------------YSG---------------------GLVS-----------------
---AYG------------------------------GLMSPGLSYAMQ------------
--------------------------------SG---------FGSGG---------SSA
SSSRV-------------------SSSKAVVVKKI------ETRDGKLVSESSDVLSK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQSSVS--FR-SGGSRSFSAASAITPS-----VSRT-SFSSV---SRSGG----G
GGGRVS--------------------------LG-------GV-CGAGGYGSRSLYNLGG
T-KRISMSAS----GF--GLRNR-------------FGPGAGS----G--FGFGSGA-G-
--------------SGYAFG--GGAI-G------------------------GF----GL
G--GGTGFG-G-GYGGAGFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPTIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTR----TVKQSL--DPLFE-QYINNLRRQLDSILG
ERGRLDSELRN-MQDLVEDFKNK-YEDEINKRTT---AENEFVMLK--K---DVDAAYMN
KVELEAKVDALMDEINFMKMFFDA-----ELSQMQTHVSDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEDIAN-RSRTEAESWYQTK--YEELQQTAGRHGDDLRNTKHEISEMN--
RMIQRLRAE-I--DNVKK------------------------------------------
-----Q-CA--NLQAAIADAEQ-RGELAL-KDARNKL----AELEDALQKAKQDMARLLR
EYQELMNTKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VG-PV-------N-ISVVTNSM----------------------------------
------------STGYGSG---------------SGFGG--SLPGGLGSG----L-----
-----G----------------------------------------GGGS----SSYYS-
-----------------------SSSG-----GVGLS--GGLNVGG-------------P
GFSAS---SGKGIGVGFGS----GGG-SGSSVKFV----STTS-S---------------
------------------------------------------------------------
-------------SRRTFKS----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

----------------------------MSEAK-ANLFGFTEECEEHQ----PKVDCPWL
CA---------------SDVSV-----PACESRMDASLPISRISSWFSPPASTPASTMSI
R--VTQKSYK--VST--SGPRAFSSRSYTSGPG-----ARI-SSSSF-------------
-------------------------------------------------------SRVGS
S----------------------------------SFRGG------------LGGRY---
------------------------------------------------------------
-------------------GGAS-------RMGGI------TAVTVNQSLLSPL----NL
EVDPNIQA--VRT QEKEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQQ-QKT-----ARSNM--DNMFE-SYINNLRRQLETLGQ
EKLKLEAELGN-MQGLVEDFKNK-YEDEINKRTE---MENEFVLIK--K---DVDEAYMN
KVELESRLEGLTDEINFLRQLYEE-----EIRELQSQISDT----SVVLSMDNSRSLDMD
SIIA-EVKAQYEEIAN-RSRAEAESMYQIK--YEELQSLAGKHRDDLRRTKTEISEMN--
RNISRLQAE-I--EGLKG------------------------------------------
-----Q-RA--SLEAAIADAEQ-RGELAI-KDANAKL----SELEAALQQAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEES---------------------------RLE-S
---GM---Q--------NMSIHTKTTSG--------------------------------
---------------YGG---------------------GLSS-----------------
---AYG------------------------------GLTSPGLSYGLG------------
--------------------------------SS---------FGSGA---------GSS
SFSRT-------------------SSSRAVVVKKI------ETRDGKLVSESSDVLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------M--
----SRQAGKK--SI-SSGSQGFSGRSAVVTG------SSR-M-SG---VTRSRAA-G--
-----GG-------------------------ASGLR----GT---AGGFGSRSLYNLGG
N-KSISFSVAAGGS-RAGGFGGGRS------IYVSGFGGGYGGGFGSGYGGGFGGGLGGG
--R--GMGGGLGGAGGLG--------GAGGLGGA-----GGFGG------------LGGL
GGLGGLGGPG--GFGG---PGGFGP-GS--FPGGI------QEVTINQSLLQPL----NV
EIDPQIGQ--VKAQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWELLQQQGTNSI--TGTNNL--EPLFE-NHINYLRNYLDSILG
ERGRLDSELRN-MQDLVEDFKKK-YEDEINKRTA---AENEFVTLK--K---DVDAAYMN
KVELQAKVDALMDEINFLRTLYDA-----ELSQMQSHVSDT----SVILSMDNNRNLDLD
SIIA-EVRAQYEDIAQ-RSKAEAEALYQTK--LGELQSTAGRHGDDLKSTKSEIMELN--
RMIQRLRAE-I--ENIKK------------------------------------------
-----Q-NA--NLQTSIAEAEQ-RGEMAL-KDANAKL----QDLQAALQQAKDDLARLLR
DYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RMS-G
ECPSA---V--------SISVVNSSS----------------------------------
-------TTSASAGGYGGGYGG-------------GLGVGGGAGS---------------
--------------------G-----------------------FGLGGG--SGLGGG--
SGLGGGIGI--GL----------GGGSGFGV---------GSGLGGGSS---F-SSGSGF
GSSSG--GR-GGVSGGGFSS----GSTRGSSIKSS----QIS------------------
------------------------------------------------------------
----------QSS-QRYIR-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------M--
----SRQVSKT--S--GGGDQGFSGRSAVVSG------SSR-M-SC---VARSGGA-S--
-----GG-------------------------ACGFR----GG---AGGFGSRSLYSLGG
N-KSISISVAG-GS-RAGGFGGGRS------S--CG------SGFGGGYGGGFGGGFGGG
--R--GMGGGFGGAGGFG--------GAGGFGGA-----GGFGGAGGFGGAGGFGGAGGF
GGPGGFGGPG--GFGG---PGGFGP-GG--FPGGI------QEVTVNQSLLQPL----NV
EIDPQIGQ--VKT QEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQQQGTNSI--TGTSNL--EPLFE-TYINNQRSYLDSILG
ERGRLDSELRN-MQDLVEDFKKK-YEDEINKRTA---AENEFVTLK--K---DVDTAYMN
KVELQAKVDALMDEINFLTTLYDM-----ELSQMQSHVSDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEDIAQ-RSKAEAEALYQTK--LGELQTTAGRHGDDLKNTKSEISELN--
RMIQRLRAE-I--ENVKK------------------------------------------
-----Q-NA--NLQVAITEAEQ-RGELAL-KDANAKL----QELQAALQQAKDDLARLLK
DYQELMNVKLALDVEIATYRKLLEGEE--------------------------CRWGG-G
GG----------------------------------------------------------
-------------------------------------GSGSGSGF---------------
--------------------SF----GGG-----------SGSGIGIGSG----IGSG--
S-GGSGFGF--------------GGGS--------------------SGF--G-FGGGSG
GFGSG--AR-GGVSGGGFSS----GSSRGGSVKFS----QSS------------------
------------------------------------------------------------
----------QRF-SR--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MNRQVCKK--SF-SGGCQGFSGRSAVVS-G-----SSR-M-SC---VARSGGA-S--
-----GG-------------------------ACGFR----GGV---GGFGSRSLYSLGG
N-KSISISVA-GGS-RAGGFGGGRS------SCG----SGFGGG----YGGGFGGGFGGG
--R--GMGGGFG-------------------------------GA-----AGGFGGAGGF
GGPGGFGGPG--GFGG---PGGFGP-GG--FPGGI------QEVTVNQSLLQPL----NV
EIDPQIGQ--VKT QEKEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQQQTTGTG--SGPNNL--EPLFE-SYISFLRRQLDLVLG
ERGNLEGELKN-MQDLVEDFKKK-YEDEINKRNA---AENEFVGLK--K---DVDAAYMN
KVELQAKVDSLTDELNFLRTLYEM-----ELSQMQSHVSDT----SVVLSMDNNRCLDLD
SIIA-EVKAQYEEIAQ-RSKAEAEALYQTK--LGELQTTAGRHGDDLKNTKSEIMELN--
RMIQRLRAE-I--ENVKK------------------------------------------
-----Q-NA--NLQVAIAEAEQ-RGELAL-KDANAKL----QELQAALQKAKDDLARLLR
DYQELMNVKLALDMEIATYRKLLEGEE--------------------------C-RMS-G
ECQSA---V--------CISVISNVTST--------------------------------
---------SSGSAGSHG-GVSA--S----SS--GG---YRGGS----------------
---------------SSRGSSGG-YGGLSG---------GSSGSYQSGSS-GG---RL--
----------------------------------------SS--GGSSSV-----SRSGI
GSASG--GI-QTSGGSSYKS----GSGGSTSIRFS----QTT------------------
------------------------------------------------------------
----------SSS-QHCSK-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MASKTTMR--TQTTSTRRGFSSGSARVSR-----PSHS-GFSSVS-VSRSRASGGLG
G-------------------------------AC-----------AGAGFGSRSLYGVGG
S-QRISVAGG----RY--GTGSS-------------YSG--RF----GGGFGFGGAS-G-
--------------SGFGFG--SG--V------GG-----------------GF----GL
G--GG-FG--------ASGP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPTIQR--VRTEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVRQSL--EPLFE-QYINNLRRQLDSILG
ERGRLDSELRS-MQDLVEDFKNK-YEDEINKRTA---AENEFVTLK--K---DVDAAYMN
KVELQAKVDGLTDEINFLRAFYDA-----ELSQMQTQISDT----SVVLSMDNNRHLDLD
SIIA-EVRAQYEDIAQ-RSRAEAEAWYQTK--YEELQVTAGRHGDDLRNTKQEIAEIN--
RMIQRLRSE-I--DHVKK------------------------------------------
-----Q-CA--NLQAAIADAEQ-RGELAL-KDARSKL----EGLEDALQKAKQDMARLLK
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VG-QV-------N-ISVVQSTM----------------------------------
------------SSGYGSGS-------------------GS--GYGS-------------
---------------------------------------GSGLALGGG-S----SYSY--
------------------------SSG--------------HDLG--------------G
GFSSG---STRGLG--GGLS--SAGGS-TSSVKYT----TTTS-----------------
------------------------------------------------------------
-------------SRRSYRQ----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MLARHQGIR-----A-SSTGFSSGSAV-VGR----GRRA-AFSSVS---ITGGG----
-----------------------------------------GRSSSSGGFGSKSLYNFGR
N-RC--MSVAGGRQ-GA-GFG---------------FGA---------------------
-----------GGAGGFGA---------------GGFGAGGFG-----------------
--AGGFGG----AFN--GQGGPNFA-VC--PVGGI------QEVTINQSLLTPL----HL
EIDPEIQK--VRTEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-ILETKWNLLQQQTTTT----SSKNL--EPYFE-SYISCLKKQLDSLVN
DKSRLQSELKI-MQDSVEDFKKK-YEDEINKRTT---AENDFVVLK--K---DVDAAYMN
KVELQAKVDAQNDEINFLRTLYEM-----ELSQMQNHVSDT----SVIVSMDNNRSLDLN
SIIS-EIQLQYENIIQ-KSKEEAQNLYQNE--VQQLQISVDLYGDNLKTTKSEISELN--
RMIQRLRAE-I--ENVKK------------------------------------------
-----Q-CQ--TLQTSVSDAEQ-RGELAL-KDALSKQ----TELEGALRKAKEELTRLLR
EYQDLMNVKLALDLEIATYRKLLEGEE--------------------------C-RMS-G
ECQSA---V--------NISVVGGSVSSGS------------------------------
---------------LRGAF---GS-----------------------------------
----Y-S------------------------GHGLGSSLGGGSGFGISG-----------
------GSSSTKIVSSTTMGKRTSR-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSM
K--VTQKSYK--ISS-TSGPRSFSSHSYSSGPA-----SRV-VSSST-------------
-------------------------------------------------------LTRMG
S---------------------TS-----------GGRAS------------FNSSM---
--------------SLMG------------------------------------------
-----------------GYGGVG-------SMGGI------TAVTVNQSLLKPV----PR
EVDPNIQA--VRIQEKEQIKTLNDKFASF------IDK--VR------------------
----TLEQQNK-ILETKWSLLQQ-QKT-----SRSNM--DNMFE-SYINNLRRQLEGLAQ
EKMKLEVELGN-MQGLVEDFKNK-YEDEINKRTE---MENEFVLIK--K---DVDEAYMN
KVELESRLEGLTDEINFYRQLYEE-----EIRELQSQISDT----AVVLSMDNSRTLDLD
GIIA-DVKAQYEAIAN-HSRAEAESMYQIK--YEELQKLAGKHGEDLRRTKTEISDMN--
RNITRIQAE-I--EGYKN------------------------------------------
-----Q-XX--XXXXXXXXXXX-XXXXXX-XXXX----XXXXXXXXXXXXXXXXXXQQLR
EYQELMNVKLALDIEIA-YRKLLESEES---------------------------RLE-S
---GM---Q--------NLSIHTKTSSG--------------------------------
---------------YAS---------------------GLS------------------
------YG----------------------------SLPSPGM----T--------SL--
--------------------------------NS--------NFSSIG---------SPG
GFTRV-------------------SSTKAVVVKKI------ETRDGKLVSESSDVLSK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--M-SRQSTIT--FHSG-SRRGFSTTSATTPA-----AGRS-RFSSVS-VARSTG--GSG
GLGRIN--------------------------GA------------GAGFGSRSLYNLGG
T-KRVAIGG-FSSG-----FRSG-------------FGG--WA----STGFGI-----S-
--------------NGFGHG--PGIGGSF-------------------------------
--------------GGPGFP------VC--PSGGI------QEVTINQSLLTPL----NL
QIDPSLQR--VRK EEHEQIKTLNNKFACF------IDK--VC------------------
----FVEQQNK-VLETKWNLLQEQGSR----TVKQSL--EPLFD-TYINDLRRQLDGITT
ERGRLEAELRN-MQEVVEDFKIR-CEDEINKCMA---AENEFVTLK--K---DMDGAYMN
KVELEAKVDALTDQINFYQMIFEV-----ELSQRQTQVSDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEDIAN-HSRAEAESWYQSK--YEELQVTAGRHGNDLRNTKQEISEVN--
RMIQRLRAE-I--DSVKK------------------------------------------
-----Q-CS--SLQTAIADAEQ-RGELAL-KDARAKL----VGPEEALQKAKQDMARLLR
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VS-PVNIS--------VVTSTI----------------------------------
------------SSGYGSGS--GIA-----------------------------------
---------------------------------------GGSLGLGGGNG----YSFTT-
-----------------------SG-------GHSLG--T--GLGG-------------S
GFTAS---SSLGLGG------------SGSRVKFI----STKS-----------------
------------------------------------------------------------
------------SSRKNYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MIARQQCVR-----G-GPRGFSCGSAIVGSG----KRG--AFSSVS---VSGGA----
-----------------------------------------GRCS-SGGFGSRSLYNLGG
N-KSISMSVAGSRQ-GA-CFGGAGG-----------FGT---------------------
---------------------------------------GGFG-----------------
---GGFGG----SFS--GKGGSGFP-VC--PAGGI------QEVTINQSLLTPL----HV
EIDPEIQK--VRT EEREQIKLLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWKLLQQQTTST----SSKNL--EPLFE-TYLSVLRKQLDTLVN
DKGRLQSELKT-MQDSVEDFKTK-YEEEINKRTA---AENDFVVLK--K---DVDAAYMN
KVELEAKVDSLNDEINFLKVLYDA-----ELSQMQTHVSDM----SVVLSMDNNRNLDLD
SIIA-EVRAQYEEIAQ-RSKAEAEALYQTK--VQQLQISVDQHGDNLKNTKSEIAELN--
RMIQRLRAE-I--ENIKK------------------------------------------
-----Q-CQ--TLQASVADAEQ-RGENAL-KDAHSKR----IELETALQQAKEELARMLR
EYQELMSVKLALDIEIATYRKLLEGEE--------------------------C-RMS-G
ECQSA---V--------SISVVGGSTSTGG------------------------------
---------------ISG-G---LGS-----------------------------GS---
---GFGL------------------------SSGFGSG--SGSGFGF--G-GS-------
----VSGSSSSKIISTTTLNKRR-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
----------------------------------------------------------MR
S-SVSRQTYST--------KGGFSSNSASGG---GGSRMRT-SYSSVT-MSRSSGS--S-
--------------------------G---GV---------RSCPGSGGFGSRSLYNLGG
--KGISVSVAGGASSG-RAL----------------------------------------
--------------GGFG--------------------SGAYV-----------------
-------GLG-------AGRQTFGP-VC--PPGGI------QEVTVNQSLLTPL----NV
EIDPEIQR--VRT QEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQSQNTG--VTR-NL--EPLFE-TYLSNLRRQLDAKQS
ERGRLDMELRN-VQDNLEDFKNK-YEDEINKRTA---LENEFVLLK--K---DVDAAYMG
RMDLHGKVDTLTQEIDFLQHLFEM-----ELSQVQTHVSDT----NVVLSMDNNRSLDLD
SIIA-EVKAQYELIAQ-RSRAEAESWYQTK--YEELQVTAGKHGDNLRDTKNEIAELT--
RTIQRLQGE-V--DATKK------------------------------------------
-----Q-CQ--QLQTAIAEAEQ-RGEMAL-KDAKKKL----GDLDTALHQAKEDLARLLR
DYQSLMNVKLALDVEIATYRKLLESEE--------------------------S-RMS-G
ECPSA---V--------SISVTGNSTSVVG------------------------------
-----------------GG--------------MAGFGSGLSLGGA---GG--ASKGSFS
AN----------------------------------------VNYGT----------A--
KSGQVSG--GTSILRKT--TTVKTSSRRY-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQSSVS--FR-SGGSRSFSAASAITPS-----VSRT-SFTSV---SRSGG--GGG
GFGRVS--------------------------LG-------GACGA-GGYGSRSLYNLGG
S-KRISISTS----GG--GFRNR-------------FGAGAGA----GGGYGFGGGA-G-
--------------SGFGFG--GGAG--------A-----------------GF----GL
G--GGA-GFGG-GFGGPGFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPTIQR--VRTEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVRQNL--EPLFE-QYINNLRRQLDSILG
ERGRLDSELRN-MQDLVEDFKNK-YEDEINKRTT---AENEFVMLK--K---DVDAAYMN
KVELEAKVDALMDEINFMKMFFEA-----ELSQMQTHVSDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEDIAN-RSRTEAESWYQTK--YEELQQTAGRHGDDLRNTKQEISEMN--
RMIQRLRAE-I--DNVKK------------------------------------------
-----Q-CA--NLQNAIADAEQ-RGELAL-KDAKNKL----AELEEALQKAKQDMARLLR
EYQELMNTKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VG-PV-------N-ISVITNSM----------------------------------
------------SSAYGGGS-G--------------FGG--GS--GFGGG----L-----
-----GGGLGGGL--------------------------GGGLG-GGGSG----SYYSS-
------------------------SSG-----GVGLG--GGLSVGG-------------S
GFSAG---SGRSLGMGFGS---GG-G-SSSSVKFV----STTS-S---------------
------------------------------------------------------------
-------------SRKSFK-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MNRQVCKK--SF-SGRSQGFSGRSAMVS-G-----SSR-M-SC---VARSGVA-G--
-----GG-------------------------ACGFR----SGA---GGFGSRSLYNLGG
N-KSISISVAAGGS-RAGGFVGGQS------SCG--FAGGYGGG----FGGSYGGGFGGG
--R--GIGSGFG-------------------------------GAGGFGGAGGFGGPGVF
GGLGSFGSPG--GFV----P------GG--FSGGI------QEVTINQSLLQPL----NV
EIDPQIGQ--VKA QEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWELLQQQTTG----LGPSSL--EPCFE-SYINFLRKQLDSLLA
ERGNLEGELKS-MQDLVEDFKKK-YEDEINKRTA---AENEFVGLK--K---DVDAAFMN
KVELQAKVDSLTDEVSFLRTLYEM-----ELSQMQSHVSDT----SVVLSMDNNRCLDLD
NIIA-EVRAQYEEIAQ-RSKAEAEALYQSK--LGELQTTAGRHGDDLKNTKSEIMELN--
RMIQRLRAE-I--ENVKK------------------------------------------
-----Q-NA--NLQTAISEAEQ-RGEMAL-KDANAKL----QDLQAALQKAKDDLARLLR
DYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RMS-G
ECQSA---V--------CISVVSNVTST--------------------------------
---------SGSSGSSRGVFGGVSG------S--GGYRGGGSSSS---------------
--------------------SSA-YGAVSG---------GSSSSYGGVSS-GS---TG--
GR-GSSGGYQ--------------------SSSS------GSRLGGAGSMS---MSHSGM
GSSSG--SV-QTSGGSGYKS----GGGGSTSIRFS----QTT------------------
------------------------------------------------------------
----------SSS-QHNSTK----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRISFR---SSTGGGMRGFSSGSAIVGGGG--SGTRS-SFSSVS-VSRVGGGRA--
-------------------------------------GG-GGGFGAGGGFGSRSLYNLGG
S-KRISYS---S----VG-GGLRSG-----------A--GGGYG--------FGLG----
-------YG--GG-AGAGFGLGGAG-GGGGY---------------G--L----GSGFGL
GGP---------GFG--GRGGPGFP-VC--PPGGI------HEVTVNQSLLAPL----KL
DIDPEIQK--VRTQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWTLLQEQGHTV----TRKSL--EPIFE-AYINNLRRQLDSLVG
ERGRLDSELRS-MQDMVEDFKNK-YEDEINRRTG---AENEFVVLK--K---DVDGAYMN
KVELQGKADALAEEINFLRALYEA-----ELSQMQQQVSDT----SVVLSMDNNRSLDLN
SIIA-EVKAQYEDIAN-RSRAEAEAWYQNKQ-YEELQVSAGRHGDDLRNTKIEISEIN--
RMVQRLRNE-I--DSVKK------------------------------------------
-----Q-CA--NLQAAIAEAEE-RGEMAL-KDAKAKL----TELEDALQKAKADLARQLR
EYQELMNVKLALDIEIATYRKLLEGEE--------------------------S-RLA-G
EGVG-A--V--------SVSVVSSSSGMGY------------------------------
------------GGGSCPPPPPGGGG----GV-GYG------------------------
------------------------------------------------------------
---------VS--------------GG---------------GFGGSGGFSGGHSYGGGS
SFSSG--SS-R-----GL--SS----STGGSVRIV----SKT------------------
------------------------------------------------------------
----------TTS-KKTIR-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQST----VRIQRGRSGFSAASAIVPG-----TCRT-SFSSRS-VTHAGGCNA--
-------------------------------------GSGFARVGG--GFGSRSLYNFGG
C-KRISAAGRGGG----F-Y--GA------------------------------------
--------------AGFGG--------G--AGSMLG------------------------
---------Y--GYGA-FG-GPGF------PAGGI------QEVSINQSLLKPL----NL
EIDPSIQR--IRKEEKEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWSLLQEQGMKT----VRNNL--EPLFE-TYINNLRMQLNSLLS
DKGRLEGELVN-TQYLVEDFKKK-YEDEINRRTI---AENEFVTLK--K---DVDASYMN
KVELQAKADALTEEINFLRALYEA-----ELSQMQTQISDT----SVVLTMDNNRNLDLD
SIIA-EVKAQYEDIAN-RSRAEAESWYQTK--YEELQATAGRHGDDLRSTKQEISELN--
RHVQRLRAE-I--DSVKK------------------------------------------
-----Q-CA--NLKAAIADAEE-RGEIAL-KDAKAKL----AELEDALQQAKADLARQLR
EYQELMNVKLALDIEIATYRKLLEGEE--------------------------C-RLA-G
DGV--P--V--------NISVTRTTV----------------------------------
----------------GSGYGGGSNL----SMGG-----------------GMCTVTRTA
VGSGYGSGS---------------------------------------------------
-------------------------CQSF-RGSS------GAGSGLCAG---------GM
GFSSG--SG-Q-GMAGSCV-VG----GSSSSMQYI----SSS------------------
------------------------------------------------------------
-----------ST-KRCY------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
----------------TSGPRAFSSRSYTSGPG-----ARI-SSSSF-------------
-------------------------------------------------------SRVGS
-----------------------S-----------SFRGG------------LGG-----
---------------GYG------------------------------------------
-----------------GASG---------------------------------------
MVDPNIQA--VRTQEKEQIKTLNNKFASF------IDKICIW------------------
----FLEQQNK-MLETKWSFLQQ-QKT-----AGSNM--DNMFK-SYINNLRRQLETLGW
RWSLA-TCR-----GWWRTSR-----TSMRMRSISVQRWRMNLSSS--R---RVDEAYMN
KVELESCLEGLTDEINFLRHLYEE-----EIRQLQSRISDT----SVVLSMDNSRSLDMD
SIIA-EVKAQE-EIAN-RSRAEAESTYQIK--CEELQSLTGKHGDDLRRTKTEISEMN--
RNISRLQAE-I--EGLKG------------------------------------------
-----Q-RA--FLEAAIADAEQ-CGELAI-KDANA-V----VELEAALQRAKQDVAWQLR
EYQ-LMNVKLALNIEIATYRKLLEGEES---------------------------RLE-S
---GM---Q--------NMSIHT-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MTQRSSVT--IK-SGGTRNFSASSASLLP-----GCRP-SFSSVS-VSQ--GGKGFG
G-------------------------------SF------------GGGFGTRSLHSFGG
S-KRISISGG----YR--C------------------GR--AS----GGGAGYGLGLGG-
--------------MGYRAG----------------------------------------
----------G-AFGGYGFG--GGM-MS--GSGGI------QEVTVNQSLLTPL----HL
EIDPSLQR--VRKEEKEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWSLLQEH--K----TARANI--EPMFE-AYISNLRRQLDCLGG
ERTRLETELKN-MQDVVEDFKNK-YEEEINRRTV---AENEFVVLK--K---DVDAAYMN
KVELEAKVDALMDEINFLRAFYDA-----ELAQLQAQISET----SVVLSMDNNRKLDLD
SIIS-EVKAQYEDIAN-RSRAEAESWYQTK--YEELQRSAGRHGDDLRTTKMEISELN--
RVMQRLRSE-I--DNLKK------------------------------------------
-----Q-CA--TLQNAIADAEQ-RGELAL-KDAKHKL----AELEDALQKAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEE--------------------------C-RLT-G
EG--VG-PV-------N-I-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTQKSYR--VST--TGPGAFSSRSFTSGPS-----ARS-SSSSF-------------
-------------------------------------------------------SRVSS
T----------------------------------GFRGG------------LGAGY---
--------------A---------------------------------------------
------------------GASGI-------GPGGI------TAITINQSLLNPI----KL
DMDPNIQA--VRT QEKEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQQ-LKT-----ARSNM--DNMFE-SYINNLRRQLETLGQ
EKLKLEAELGN-IQGPVEDFKNK-YEEEINKRTE---VENEFVLIK--K---DVDEAYMN
KVELESRLEGLTDEIHFLRQLYEE-----EIRELQSQISDT----SVVLSMDNNHSLDMD
SIIA-EVKAQYEEIAN-RSRAEAESLYQIK--YEELQKLAGKHGDDLRRMKTEISEMN--
RNISRLQAE-I--EGLKG------------------------------------------
-----Q-RA--SLEAAILDAEH-RGEQAL-KDACAKQ---QQQLEEALQKAKQDMARQLR
DYQELMNVKLALDIEI--------GEES---------------------------WLE-C
---GM---Q--------NMSIHTKTTSG--------------------------------
---------------YAG---------------------GLSS-----------------
---AYG------------------------------GLTSPSLSYSLG------------
---------------------------------S--------SFGSGV---------DS-
TFSRT-------------------SSTKAVVVKKT------ETRDGRLVSESSDVLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--TMSRQSR--------ALGKGFSSSSVCFGGKN-----K----VALG-AAQRG------
-----------------------------------------GCRGPAGGFSSRSLYSLGG
T-KSTSLGGFGGAG-GAC------------------------------------------
--------------RGFGG--------QGGFGFGGGFG----------------------
-------GFGG-GFDG-GMGGQGFP-PC--PPGGI------REVTINQSLLAPL----NL
EIDPEIQK--VRTQEREEIKKLNDKFASF------IDK--VR------------------
----FLEQQNR-VLQTKWELLQQQAGP----TGGRNL--DPFFE-TYISGLRKQLDGLSS
EKLQLETELKS-FQDMVEDFKTK-YEEEINKRTA---AENEFVLLK--K---DVDAAYMT
KVELQGKLDSLSDEINFLKCLYEA-----ELSQMQKSVSDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEDIAN-RSRAEAEAWYRCK--YEELQATAGKHGDSLKDTKIEISELN--
RMIQRIRAE-I--ESVKK------------------------------------------
-----Q-CE--TVQTSIADAEQ-RGEVAL-KDARDKL----TELETALQKAKADMARQLR
EYQELMNVKLALDVEIATYRTLLEGEE--------------------------C-RMS-G
ECQS-S--V--------SISVVGGSSSVGG------------------------------
------------GY--------GSGL----CLGGGGIGFGSGKGSCNTGGAGLCF---S-
--------------------------------------------LGGG------------
--------------------------------GF------GAGGGFGS------------
-LGGG--SN------SVVV--G----GSGSVLKNA----GPA------------------
------------------------------------------------------------
----------GR---RA-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTQKSYK--VS--TSGPGAFSSRSFTSGPS-----ARW-SS----------------
---------------------------------------------------------S-M
S---------------------ST-----------GFRGG------------LGAGY---
--------------AG--------------------------------------------
-------------------ASGI-------GMGGI------TAVTITQSLLNPI----KL
DVDPNIQA--VCT QEKEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWSLLQQ-QKT-----ARSNM--DNMFE-SSINNLGRQLETLGR
EKLKLEAELGN-MQGLVEDFKNK-YEEEINKRTE---MESEFVLIK--K---DVDEADMN
KDEETREL---------------------------------------------HRSLDVD
SILA-EVKAQCQEIAN-RSRAEADSEYRTK--YEELQTLAGKHGDGLRRTKTEISEMN--
RNISRLQAE-I--EGLKV------------------------------------------
-----Q-RA--SLEAAIIDAEH-RGEQTL-KDARAKQ----QQLEAALQNAKQDMARQLP
DYQELTNVRLALDMEIATYRKLLEGEES---------------------------RLE-S
---GM---Q--------NMSIHTKTTSS--------------------------------
---------------YAG---------------------GLSS-----------------
---VYG------------------------------GLTSPGLSYGLG------------
---------------------------------S--------SFGPGA---------GS-
TFSGT-------------------SSTKAVVVKKI------ETRDASL---SSDVLPKR-
--AAATA--PP----SLPLLRLPQSPGGRPLCKGAQG----TGDPSDSQP----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

MTSVGVF---------TDMLSRCTKDGPVPEAQPRDVSDVSLYAPVTKPFCS--------
------------------------STYKRPRLRALAFTGLVPL----A---SLIAPSSLS
PAMASRQTYIR-----G-GSRGFSGGSAIVGGG----RRA--AFSSVS---VSGGA----
-----------------------------------------GRCS-SGGFGSRSLYNLGG
N-KSTSISVAGCRQ-GAAGFGGAG------------------------------------
-----------------------------------GFGAGGFG-----------------
---GGFGG----SFN--GRGGSGFP-IC--PAGGI------QEVTINQSLLTPL----HV
EIDPEIQK--IRTEEREQIKSLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWKLLQQQTATT----SSKNL--EPFFE-CYLNALRKQLDGLIN
DKGRLQSELKV-MQDSVEDFKAK-YEDEINKRTT---AENDFVVLK--K---DVDAAYMN
KVELQAKVDSLNDEINFLRALYEA-----ELSQMQTHVSDT----SVVLSMDNNRCLDLD
SIIA-EVRAQYEEIAQ-KSKAEAEALYLTK--VQQLQNSVDQHGDNLKNTKSEIAELN--
RMIQRLRAE-I--ENVKK------------------------------------------
-----Q-CQ--ALQTSVADAEQ-RGESAI-KDAYSKR----AELEAALQKAKEELARMLR
EYQELMSVKLALDVEIATYRKLLEGEE--------------------------C-RMS-G
ECQSA---V--------SISVVGGTASASG------------------------------
---------------ISG-R----------------------------------------
----FGL------------------------GGGFGSG--SGSGFGF--G-GG-------
----ISGSSGSKIVSTTSLTKRSY------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------MSMHFSSRSAAFPGR----------LSSG----RPGA-----
----------------------------------------------LGSS-SSSLYGLG-
------------AS-RPHVAL--RS-----------------------------------
---------------VHG------------------------------------------
----------------A-------P-----VGAGI------REVTINQSLLAPL----RV
DIDPAMQL--VRQ EEREQIKALNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWTLLQEQKSA-----KSSPL--PGVFE-AQISGLRRQLETLQA
DGGRLDVELRN-MQDGVEDFKNK-YEEEINRRTA---AENEFVVLK--K---DVDAAYTN
KVELEASVNSLNDEIMFLRSLNEM-----ELTELQSQISDI----SVVLSMDNNRSLNLD
GIIA-EVKAQYEEIAN-LSQAEAEAWYQTK--FKTLQAQAGKHGADLRNTRNEIADMN--
RAIQRLQSE-V--DNVKN------------------------------------------
-----Q-RA--KLEASITEAED-RGEMAL-RDARGKQ----EELEAALQQAKQDKARQLR
DYQHLLNVKLALDVEITTYRKLLEGEE--------------------------S-WLA-G
DAVGA---V--------NISM---------------------------------------
----MKS----------TGA----------------SGSGLVFGG-----TMGSNALSFS
SS-----GAPGA------------------------------------------------
--------LKASSIRTTSTARRNFN-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
MA--STSTTIR--NH-SSSHRGFSASSARLPG-----VSRS-GFSSVS-VSRSRGSGGLG
G-------------------------------AC-----------GGAGFGSRSLYGLGG
S-KRISIGGR----SC--AISGG-------------YGS--RA----GGSYGFGG-A-G-
--------------SGFGFG--GG--A------GI-----------------GF----GL
G--GG-AGLAG-GFGGPGFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPTIQR--VRA EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVRQNL--EPLFE-QYINNLRRQLDSIVG
ERGRLDSELRN-MQDLVEDLKNK-YEDEINKRTA---AENEFVTLK--K---DVDAAYMN
KVELQAKADNLTDEINFLRALYDA-----ELSQMQTHISDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEEIAQ-RSRAEAESWYQTK--YEELQVTAGRHGDELRNTKQEIAEIN--
RMIQRLRSE-I--DHVKK------------------------------------------
-----Q-CA--SLQAAIADAEQ-RGEMAL-KDAKNKL----EGLEDALQKAKQDLARLLK
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLN-G
EG--VG-QV-------N-ISVVQSTV----------------------------------
------------SSGYGGASG-------------------------I-------------
---------------------------------------GSGLGLGGGSS----YS----
-----------------------YGSG--------------LGVG--------------G
GFSSS---SGRAIG--GGLS--SVGGG-SSTIKYT----TTSS-----------------
------------------------------------------------------------
------------SSKKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------XG-
--------------------------G---GV---------RSGSSSGGFGSRSLYNLGG
--KNISISVAGGSSSG-RAL----------------------------------------
--------------GGFG--------------------SGAYV-----------------
-------GLG-------AGRQTFGP-VC--PPGGI------QEVTVNQSLLTPL----NV
EIDPEIQR--VRT QEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQSQNTG--VAR-SL--EPFFE-GYLNTLRRQLDTKQS
ERGRLDMELRN-VQDNLEDFKNK-YEDEINKRTA---LENEFVLLK--K---DVDAAYMG
RMDLQSKVESLIQEIDFLQQLHEM-----ELSQVQTSVSDT----NVILSMDNNRSLDLD
SIIA-EVKAQYELIAQ-KSRAEAESWYQTK--YEELQVTAGKHGDSLRDTKNEISELT--
RTIQRLQGE-V--DAVKK------------------------------------------
-----Q-CQ--QLQTAIAESEQ-NGEMAL-KDAKKKL----GDLDTALHQAKEDLARMLR
EYQDLVSVKLALDMEIATYRKLLESEE--------------------------S-RMS-G
DCPSA---I--------SISVTGNSTSVCS------------------------------
-----------------GG--------------AAGF----SLGGA---GG--ASKGGYS
TS----------------------------------------AIHGS----------A--
KGGQVSG--GTSILRKT--TTVKTSSRRY-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
H-------------F---SSPVFTSRSAAFSGR----GAQV-RLSSA----RPGG-----
----------------------------------------------LG-S--SSLYGLG-
------------AS-RPRVAV--RS-----------------------------------
---------------AYG------------------------------------------
----------------G-------P-----VGAGI------REVTINQSLLAPL----RL
DADPSLQR--VRQ EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-LLETKWTLLQEQKSA-----KSSRL--PEVFE-AQIAGLRGQLEALQV
DGGRLEAELRS-MQDVVEDFKNK-YEDEINRRAA---AENEFVVLK--K---DVDAAYMS
KVELEAKVDALNDEINFLRTLNEM-----ELTELQSQISDT----SVVLSMDNSRSLDLD
SIIA-EVKAQYEEMAK-CSRAEAEAWYQTK--FETLQAQAGKHGDDLRNTRNEISEMN--
RAIQRLQAE-I--DNIKN------------------------------------------
-----Q-RA--KLEAAIAEAEE-RGELAL-KDARAKQ----EELEAALQRTKQDMVRQLR
EYQELMSVKLALDIEIATYRKLLEGEE--------------------------S-RLA-G
D-------G--------VGA-----VN---------------------------------
-ISVVNST-GG-----SSNG----------------GGIGLTLGG-----TMGSNALSFS
SG-----AGPGP------------------------------------------------
--------LKAYSIRTTSTSRRSARN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--M-SRQSTVT--FQTG-SHRGFSTASASTPA-----AGRS-RFSSAS-VARSTG--SST
GLGRIS------------------------------------------GFGSRSLYNLGG
A-KRVSVSGC-GSN-----FRSG-------------FGS--RA----SSGFGV-----S-
--------------NGFGHG--SGIGGGY-------------------------------
--------------GGAGFP------TC--PSGGI------QEVTVNQSLLTPL----NL
QIDPTIQR--VRKEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQEQGSR----VVRQSL--EPLFD-AYINGLRRQLDSITN
ERGRLDAELRS-MQEVVEDFKVR-YEDEINKRTA---AENEFVALK--K---DVDGAYMN
KVELEAKVNTLTEETNFLRMIYEA-----ELSQMQNQVSDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEDIAN-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEISEMN--
RMIQRLRSE-I--DNVKK------------------------------------------
-----Q-CS--SLQTAIADAEQ-RGELAL-KDARSKL----VDLEEALQKAKQDMARLLR
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------H-RLS-G
EG--VS-PVNIS--------VVTSTV----------------------------------
------------SSGYGGGS-NSFG-----------------------------------
---------------------------------------GGNLGLGGGSS----YSFTT-
-----------------------SG-------GHSLG--T--GLGG-------------S
GFSAT---SSRGLGG------------SGSSVKFV----STTS-----------------
------------------------------------------------------------
------------SSRKTYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSR
QFS-SRSGYR---SG-----GGFSSGSAGIVN-----YQRR-TTSSS--TRRSGGGG---
G--RFS------------------------S--CGGGG--GGSFGAGGGFGSRSLVNLGG
S-KSISISVARGGG-R-SGFGGG---------Y-G---GGGFGG------GGFGG-----
--------------GGF-----GG----GGFG-GGGIGGGGFGGFGSG------GGGFG-
G---------G-GFGGGGYGGGYGP-VC--PPGGI------QEVTINQSLLQPL----NV
EIDPEIQK--VKSREREQIKSLNNQFASF------IDK--VR------------------
----FLEQQNQ-VLQTKWELLQQVDTST----RTHNL--EPYFE-SFINNLRRRVDQLKS
DQSRLDSELKN-MQDMVEDYRNK-YEDEINKRTN---AENEFVTIK--K---DVDSAYMT
KVDLQAKLDNLQQEIDFLTALYQA-----ELSQMQTQISET----NVILSMDNNRSLDLD
SIIA-EVKAQYEEIAQ-KSKAEAESLYQSK--YEELQITAGRHGDSVKNSKIEISELN--
RVIQRLRSE-I--DNVKK------------------------------------------
-----Q-IA--NLQQSISDAEQ-RGESAL-KDAKNKL----NDLEDALQQAKEDLARLLR
DYQELMNTKLALDLEIATYRTLLEGEE--------------------------S-RMS-G
ECAP-N--V--------SVSVSTSHTTISG------------------------------
------------GGGRGGGG--GGYS-----SGGGSYGSG-----------GGSYGS---
---GGGGG-GGRGSYGSGG---GSYGSGG-------GG-GGGRGSYG-SG-GGSYGSGGG
GGGGGHGSYGS-----------GSSSGGY-RGGS------GGGGGGSSGGR-----GSGG
GSSGG--S----IGGRGSSSGGVKSSGGSSSVKFV----STT------------------
------------------------------------------------------------
----------YSG-VTR-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MCM
R--VTQKSYK--VST--SGPRAFSSRSYTSGPG-----AHI-SSSSF-------------
-------------------------------------------------------SRVGS
S----------------------------------CFRGG------------LGGGY---
--------------G---------------------------------------------
------------------GASG---------MGGI------TAVTVNQSLLSPL----VL
EVDPDIQA--VCT QEKEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQQ-QKT---------------------------------
EKLKLEAELGN-MQGLVEDFKNK-YEDEINKRAE---MENEFVLIK--K---DVDEAYMN
KVELESRLEGLTDEINFLRQL---------------------------------RSLDMN
SVVA-EVKAQYEEIAN-RSRAEAESMYQIK--DEELQSLAGKHGDNLRCTKTKISEMN--
RNISRLQAE-N--EGLKG------------------------------------------
-----Q-RA--FLEAAIADAEQ-CGELAI-KDAN---------LEAALQRAKQDMAWQLR
EYQELMNVSLALDIEIATYKKLLEGEES---------------------------RLE-S
---GM---Q--------NMSIHTKTTSG--------------------------------
---------------YAS---------------------GLSS-----------------
---ACG------------------------------GLTSPGLSYGLG--------S---
---------------------------------S--------SFS---------------
C---T-------------------SSSRAVVVKKI------ETRDGKLVSESSDVLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTQKSYK--VST--SGPRAFSSRSYTSGPV-----SRI-SSSSF-------------
-------------------------------------------------------SRVGS
S----------------------S-----------SFRGG------------LG------
-------------------L----------------------------------------
---------------GGY-GGA-----------------------VNQSLLNPL----NL
EVDPNIQA--VRIQEKEQIKNLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQQ-QKT-----SRSNM--DNMFE-SYINNLRRQLDTLGQ
EKLKLEAELGN-MQGMVEDFKNK-YEDEINKRTE---MENEFVLIK--K---DVDEAYMN
KVELESRLEGLTDEINFLRQLYEE-----EIRELQSQISDT----SVVLSMDNSRSLDLD
GIIA-EVKAQYEEIAN-RTRAEAESMYQIK--YEELQTLAGKHGDDLRRTKSEISEMT--
RSISRLQAE-I--EALKG------------------------------------------
-----Q-RA--ALEAAIADAEQ-RGEMAI-KDANAKL----AQLESALQKAKQDMARQLR
EYQELMNVKLALDIEIATYCKLLEGEEN---------------------------RLE-A
---GM---Q--------NLSIHTKTTSG--------------------------------
---------------YAG---------------------MVSS-----------------
---PYG------------------------------GLTS--------------------
----------------------------------------------------------PG
F---T-------------------RTKSAVVVKKI------ETRDGKLVSETSDVLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSC
KSTLR---------GQGSSHRSFSTSSARGPG-----LSRS-GFSSVS-VCRTRGSG---
-----G-----------------------------S----GAVCG-GAGFGSRSLYGLGG
S-RRISMGVSSCGI-G-GGYGSRVG----V------------G-----------------
--------------SGFGFG----GGAGAGLGFGG---------------------G---
-----------AGLGG-GYGGAGFP-VC--PPGGI------QEVTINQSLLTPL----NL
QIDPTIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTKT----VRQNL--EPLFE-QYINNLRRQLDSITA
ERGRLDSELRS-MQDTVEDFKNK-YEDEINKRTA---AENEFVTLK--K---DVDAAYMT
KTELQARLDGLVDEINFLRAFYEA-----ELSQMQTHISDT----SVVLSMDNNRNLDLD
SIIA-EVRAQYEEIAQ-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEIAEMN--
RMIQRLRSE-I--DHVKK------------------------------------------
-----Q-VR--WTERFSVCPSL-PV-----------------------------------
----------------SRVVAYLE-----------------------------R-RL---
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------RA
--NPLC-----------------------------------------------------S
GFSSG--SG-RGVA--SGLSSTGGSSST---IKYT----TTT------------------
------------------------------------------------------------
----------SSS-RKSYRH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQST----VRIQRGRSGFSAASAIVPG-----TCRT-SFSSRS-VTRVGGCNA--
-------------------------------------GSGFARVGG--GFGSRSLYSFGG
C-KRISAAGRGGG----F-Y--GT------------------------------------
--------------AGFGG--------G--AGSMLG------------------------
---------Y--GYGA-FG-GPGF------PAGGI------QEVSINQSLLKPL----NL
EIDPSIQR--IRKEEKEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWSLLQEQGMKT----VRNNL--EPLFE-TYINNLRMQLNSLLS
DKGRLEGELVN-TQYLVEDFKKK-YEDEINRRTI---AENEFVTLK--K---DVDASYMN
KVELQAKADALTEEINFLRALYEA-----ELSQMQTQISDT----SVVLTMDNNRNLDLD
SIIA-EVKAQYEDIAN-RSRAEAESWYQTK--YEELQATAGRHGDDLRSTKQEISELN--
RHVQRLRAE-I--DSVKK------------------------------------------
-----Q-CA--NLKAAIADAEE-RGEIAL-KDAKAKL----AELEDALQQAKADLARQLR
EYQELMNVKLALDIEIATYRKLLEGEE--------------------------C-RLA-G
DGV--P--V--------NISVTRTTV----------------------------------
----------------GSGYGGGSNL----SMGG-----------------GMCSMGNNY
SCSGPGG-----------------------------------------------------
------------------------------------------------------------
---------------SSAL-GG----GSSSSVKFF----SSS------------------
------------------------------------------------------------
-----------SS-RRSYRS----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--M-SRQSTVT--FQTG-SRRGFSTASATTPA-----AGRS-RFSSVS-VARSTG--GSG
GPGRVS--------------------------SA------------GVGFGSRSLYNLGG
P-KRVSISGC-GSS-----FRSG-------------FGG--RA----SNGFGV-----N-
--------------SGFGYG--VGIGGGF-------------------------------
--------------GGPGFP------AC--PPGGI------QEVTVNQSLLAPL----NL
QIDPTIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWSLLQEQGTR----SVRQNL--EPLFD-AYISDLRRQLESITN
ERGRLEAELRN-MQDTVEDLKVR-YEDEINKRTA---AENEFVALK--K---DVDAAYMN
KVELEAKVKSLADELNFHRLVFEA-----ELSQMQTQVSDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEDIAN-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEISEVN--
RMIQRLRAE-I--DSVKK------------------------------------------
-----Q-CS--SLQTAIADAEQ-RGELAL-KDARAKL----VDLEEALQKAKQDMARLLR
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------S-RLS-G
EG--VA-PVNIS--------VVTSTV----------------------------------
------------SSGYAGGS--SIG-----------------------------------
---------------------------------------GGSLGVGGGSS----YSFTT-
-----------------------NG-------GHSLG--A--GLGG-------------S
GFSGS---SSRGPGG------------SGSSVKFV----STTS-----------------
------------------------------------------------------------
------------SSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
----------------------------------------------------------MR
-SSRSRQTYAT--------KGGFSSNSASGG---GGSRTHT-SFSSVT-MSRSSGSGGG-
--------------------------V--------------RCGPSTGSFGSRSLYNLGG
S-KSISVSVA---SSG-RAL----------------------------------------
--------------GGFGHS------------------SGAYG-----------------
-------SLG-------AGRQTFGP-VC--PPGGI------QEVTINQSLLTPL----NV
EIDPEIQR--VRTQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQGQNMG--VTRNNP--EPLFE-AYLSNLRRKLDSLLG
ERGRLDAELRN-VQDGLEDFKNK-YEDEINKRTA---LENEFVVLK--K---DVDAAYMG
KMDLHGKVDALVQEVDFLQQLYET-----ERSQVQTHVSDT----NVILSMDNNRSLDLD
SVIA-EVKAQYELIAQ-RSRAEAEAWYQTK--YEELQVTAGKHGDNLRDTKNEISELT--
RTIQRLQSE-V--DAAKK------------------------------------------
-----Q-CQ--QLQAAIGEAEE-RGELAL-KDAKKKL----GDLDTALHQAKEDLARLLR
DYQALMNVKLALDVEIATYRKLLEGEE--------------------------S-RMS-G
ECPSA---V--------SISVTGNSTTVYG------------------------------
-----------------GG--------------SAGFGGGISLGGS---GG--ASKGGFN
TN----------------------------------------VSYST----------V--
KGGPVSG--GTSILRKT--TTVKTSSQRY-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------M--
----NRQVCRK--SF-SGGSQGFSGHSAIVSG------SNR-M-SC---VARSGGA-G--
-----GG-------------------------ACGFR----SG---AGGFGSRSLYNLGG
N-KSISISVAG-GS-RAGGFGGGRS------S--CG----------SGYGGGYGGGFGGG
--R--GIGGGFGGAGGFG--------GAGGFGGA-----GGFGGPGGFGGPGGFGG----
-------GPG--GFGG---PGGFGS-SG--FPGGI------QEVTVNQSLLQPL----NV
EIDPQIGQ--VKAQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQQQGTNFT--TGTNNL--EPLFE-NYISSRRSYLDSILA
ERGRLDSELRN-MQDLVEDFKKK-YEDEINKRTA---AENEFVTLK--K---EVDAAYTN
KVELQAKVDALIEEINFLRTLYDM-----ELSQMQSHVSDM----SVILSMDNNRCLDLD
SIIA-EVKTQYEEIAQ-RSKAEAEALYQTK--LGELQTTAGRHGDDLKSTKNEIMEIN--
RMIQRLQTE-I--ESVKK------------------------------------------
-----Q-NA--NLQTAIAEAEQ-RGEMAL-KDANAKL----QELQAALQQAKDDMARLLR
DYQELMNVKLALDVEIATYRKLLEGEE--------------------------CSRMS-G
ECQNA---V--------SISLVSSSN----------------------------------
-------TTSASAGGYGGGFGG-------------GFSVGGGAGS---------------
--------------------GF----SGAG---------GSGSGFGFGGG--SGFGG---
-------------------------CNGFGG---------SSGFGG-GSG--F-GSGSGF
GSGYG--GR-RGISGGGFSS----GSNRGGSITFS----QSS------------------
------------------------------------------------------------
----------QRC-SR--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
----------------------------------------------------------MR
-SSMSRQTYST--------KGGFSSNSASGG---GRPRTHT-SFSSVT-VSRSSGSG---
-----------------------------GGT---------RCGSSSGGFGSRSLYNLGG
H-KSISVSVAGGAASG-RAM----------------------------------------
--------------GGFGLS------------------SGAYT-----------------
-------GLG-------AGRQIFGP-AC--PPGGI------QEVTINQSLLTPL----NV
EIDPEIQR--VRTQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQGQNTG--VTRNNL--EPIYE-SYVNGLRRRLDSLLG
ERGRLDSELKN-VQDLVEDFKNK-YEDEINKRTA---AENEFVVLK--K---DVDAAYMG
QMDLHGKAEALTQEIDFLQHLYEM-----ELSQVQTHVSDT----NVVLSMDNNRNLDLD
SIIA-EVKAQYELIAQ-RSRAEAESWYQ----YEELQVTAGKHGDNLRDTKNEIAELT--
RTIQRLQGE-V--DAAKK------------------------------------------
-----Q-XX--XXXXXXXXXXX-XXXXXX-XXXXXXX----XXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXX--------------------------X-XMS-G
ECPSA---V--------SISVTGNSTTVCG------------------------------
-----------------GS--------------AAGFGGGISLGGS---GG--ASKVGFS
TN----------------------------------------MGYST----------I--
KGGPVSG--GTSILRKT--TTVKKSSRRY-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
MASYHIKTTVR--SQS-SSRRGFSASSARVPG-----LSRS-GFSSAS-VCRSRGSGGIG
A-------------------------------AC-----------GGAGFGSRSLYGLGG
S-KRISIVGG----SC--ATGGA-------------YGS--RV----GGGFGFGGGL-S-
--------------SGFGYG--GG--A------GG-----------------SF----GL
G--GG-AGFGG-GYGGAGFP------VC--PPGGI------QEVTINQSLLTPL----NL
EIDPTIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWALLQEQGTK----TVRQNL--EPLFE-QYISNLRRQLDSIVG
ERGRLDTELRS-MQDTVEDYKNK-YEDEINKRTA---AENEFVTLK--K---DVDAAYMN
KTELQARADSLIDEINFLRVLYDA-----ELSQMQTHISDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEEIAQ-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEIAEIN--
RMIQRLRSE-I--DHVKK------------------------------------------
-----Q-CA--NLQAAIADAEQ-RGELAL-KDARNKL----EGLEDALQKAKQDMARLLK
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLN-G
EG--VG-QV-------N-ISVVQSTV----------------------------------
------------SSGYGSG-------------------------SNM-------------
---------------------------------------GSGMGLGGG-S----GYSY--
------------------------SSG--------------HNLG--------------G
GFSSG---SGRGISLGGGLS--SVGG-SSSSIKYT----SS-S-----------------
------------------------------------------------------------
------------SSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
H-------------F---SSPVFTSRSAAFSGR----GAQV-RLSSA----RPGG-----
----------------------------------------------LG-S--SSLYGLG-
------------AS-RPRVAV--RS-----------------------------------
---------------AYG------------------------------------------
----------------G-------P-----VGAGI------REVTINQSLLAPL----RL
DADPSLQR--VRQ EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-LLETKWTLLQEQKSA-----KSSRL--PDIFE-AQIAGLRGQLEALQV
DGGRLEAELRS-MQDVVEDFKNK-YEDEINRRAA---AENEFVVLK--K---DVDAAYMT
KVELEAKVDALNDEINFLRTLNET-----ELTELQSQISDT----SVVLSMDNSRSLDLD
GIIA-EVKAQYEEMAK-CSRAEAEAWYQTK--FETLQAQAGKHGDDLRNTRNEISEMN--
RAIQRLQAE-I--DNIKN------------------------------------------
-----Q-RA--KLEAAIAEAEE-RGELAL-KDARAKQ----EELEAALQRAKQDMARQLR
EYQELMSVKLALDIEIATYRKLLEGEE--------------------------S-RLA-G
D-------G--------VGA-----VN---------------------------------
-ISVMNST-GG-----SSSG----------------GGIGLTLGG-----TMGSNALSFS
SS-----AGPGP------------------------------------------------
--------LKAYSIRTASTSRRSARN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTQKSYK--VS--TSSPRAFSSRSYTSGPS-----SRI-SSSAF-------------
--------------------------------------------------------RVGS
C---------------------GG-----------SFRGG------------LNSSM---
--------------SVRV------------------------------------------
-----------------LGG--G-------GGEGI------TAVSVNQSLRSPL----KM
EVDPNIQV--VHTQEKEQIKSLNYKFASF------IDK--VR------------------
----HLEQQNK-ILEAKWGLLQQ-QKT-----ARSNT--DNMFG-SCIHDLRRQLDTLGQ
EKLTLEVEVGD-LQGLVEGFKNK-YEDEIKLRGD---LENEFVLIK--K---DVDEAYMH
KTELEPRREGLTDEINSG-QRHEE-----ETRELQSQISDP----SAVPSRGNSRALDLD
GVTA-EVKAQNEDIAH-RSRAQAETMHRIK--CEELQTLAGKHRDDLRRPKT-ISEMN--
RSIRRLRAE-I--EALRN------------------------------------------
-----Q-RA--APEAAVADAEP-RGEAVKDANAQVAE----PEPEAALQRDERDMARQLR
EHRELLNVRLAPDLEMGDRHRPTLGEES---------------------------RLE-P
---GM---Q--------NTSIHRKTTSG--------------------------------
---------------YPG---------------------AE-L-----------------
---GLR------------------------------GLTSPRPSYGQS--------PF--
--------------------------------QS--------SFGG-------------G
SFSRS-------------------SSSKAMVVEKI------ETRDGKLVSASSDVLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSV
H-------------F---SSQVFSSRSAAFPGR----GTQG-RLSSA----RLGG-----
----------------------------------------------LGSSSSSSLYGLS-
------------AS-RPRVAV--RS-----------------------------------
---------------SYG------------------------------------------
----------------A-------P-----VGAGI------REVTINQNLLTPL----QV
DIDPSIQQ--VRQ EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-LLETKWALLQEQKST-----KSSRL--PGIFE-AQIAGLRKQLEALQL
DGGRLEAELRS-TQDIVEDFKNK-YEDEINHRTA---AENEFVVLK--K---DVDIAYMN
KVELEAKVDALNDEISFLRTLYEE-----ELKELQSKVSDT----SVVLSMDNSRSLDLD
GIIT-EVKAQYEEIAN-RSRAEAEAWYQTK--FETLQAQAGKHGDDLRNTRNEIAEMN--
RAVQRLQAE-I--DNIKN------------------------------------------
-----Q-RA--KLEAAIAEAED-RGELAL-KDARAKQ----EELEAALQRAKQDMARQLR
EYQELMNIKLALDIEIATYRKLLEGEE--------------------------S-RLT-G
DGVGA---V--------NISV---------------------------------------
----VNS----------TGG----------------AGSRLSFGG-----TMGSNALRFS
SG-----GGPGT------------------------------------------------
--------LKSYSFRTTSATGRNTHN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTQKSYK--LST--SKPRAFSSRFYTSGPS-----AHI-SSSM--------------
-----------------------------------------------------------G
S----------------------S-----------SFQGG------------LGRGY---
--------------G---------------------------------------------
------------------GASG---------MGGI------TTVTVNQSLLSPL----NL
EVDPNIQA--VRT QEKEQIKTLNNKFASF------IDK--IR------------------
----FLEQQNK-MLETKWSLLQQ-QKM-----AQSNM--DNMFG-SYINNLTRQLETLGQ
EKLKLEVELGN-MQGLVEDFKNK-YEDEINKLTE---MENEFVLIK--K---EVDEAYMN
KVELGSRLEGLTDEINFLRQLYEE-----EIQELQCQISDT----S--------PSLDMD
SIIA-EVKVQYEEITN-HSQAEAESMYQIK--YEELQTLVGKHGNDLRRTKTEISEMN--
RNISRLQAE-T--EALKG------------------------------------------
-----Q-RT--SLEAAIADAEQ-RGELAV-KDANAEL----SELEAAQERAKQDMARPLR
EYQELMNVKLALDIQIATYRKLLEGDES---------------------------RLE-S
---GM---L--------NMSIHTKTTSS--------------------------------
---------------YAG------------------------------------------
---AFG------------------------------GLTSPGLSYSLG------------
---------------------------------S--------SFGSGA---------GSS
SFSST-------------------GSTRAVVVKKI------KTRDGKLE--SSDVLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTQKSYK--MS--SSGTWAFSSRSYTSGPG-----ACV-SSSSF-------------
-------------------------------------------------------RREGS
-----------------------S-----------NFRGD------------LGT-----
---------------GYA------------------------------------------
-----------------GVSGM--------GMGGI------TAVTVSQSLLNPL----NL
EVDPNIQA--MHTQEKEQIKTLNNKFAS-------VNK--VR------------------
----FLEQQNK-MLETKQSLLQQ-QKT-----ARSNM--DNMFE-SYFNNLGRQLETLGQ
EKLKLEAELGN-MQGLVEDFKNK-YEEEINKHTE---MENEFVLIK--K---DVDEVYMN
KVELESRLEGLTDEISFLRQLYEE-----EIWELH-------------------------
-ILA-EVKAQYEETTN-HSWAEAESVYQIK--HEELQTLGGKHEDDLQCTKTEISEMN--
RNISPLQAE-I--KGLKG------------------------------------------
-----Q-RA--SLEATTADVEQ-CGDLALED-A------------VPSSRTKQDMVWQLR
EYRELMNIKLALDIEIATYCKLLEGKES---------------------------RLE-S
---GM---Q--------NVSIHTKTTSG--------------------------------
---------------YAG---------------------GLSS-----------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------AVVVKKT------ETRNGKLVSESSDVPPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MNRQVCKK--SF-SGGSQGFSGRSAMVS-G-----SSR-M-SC---VARSGGA-G--
-----GG-------------------------ACGFR----SGA---GSFGSRSLYNLGG
N-KSISISVAAGSS-RAGGFGGGRS------SCG--FGGGYGGG----FGGSYGGGFGGG
--R--GVGSGFG-------------------------------GAGG------F------
GGPGGFGGPG--TFGG---PGGFGP-GG--FSGGI------QEVTVNQSLLQPL----NV
EIDPQIGQ--VKA QEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWELLQQQTTGSG--SGPRSL--EPCFE-SYISFLRKQLDSLLG
EKGNLEGELKN-MQDLVEDFKKK-YEDEINKRTA---AENEFVGLK--K---DVDAAFMN
KVELQAKVDSLTDEVSFLRTLYEM-----ELSQMQSHVSDT----SVVLSMDNNRCLDLD
SIIA-EVRAQYEEIAQ-RSKAEAEALYQTK--LGELQTTAGRHGDDLRNTKSEIMELN--
RMIQRLRAE-I--ENVKK------------------------------------------
-----Q-NA--NLQTAIAEAEQ-HGEMAL-KDANAKL----QDLQAALQKAKDDLARLLR
DYQDLMNIKLALDVEIATYRKLLEGEE--------------------------C-RMS-G
ECQSA---V--------CISVVSNVTST--------------------------------
---------SGSSGSSRGIFGGVSGS----GS--GGYRGGGSSS----------------
-------------------SSSG-YGGVSG---------GGSSG-YGGVS-SG---SA--
GGRGSSGGYQ--------------------SSSS------GSRLGGAGSIS---GSHSGM
GSSSG--SV-QTSGGSGYKS----GGGGSTNIRFS----QTT------------------
------------------------------------------------------------
----------SSS-QHSSTK----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MNKQVCKK--SF-SGGSQGFSGRSAVVSGG-----SSR-M-SC---VARSGGA-S--
-----GG-------------------------ACGFR----SGA---GGFGSRSLYNLGG
N-KSISISVA-GGS-RTGGFGGGRS------SCG----SGFGGG----YGGGFGGG----
--R--GMG------------------------------------------------AGGF
GGAGGFGGAG--GFGG---PGGFGP-GG--FPGGI------QEVTVNQSLLQPL----NV
EIDPQIGQ--VKAQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQQQTTGSG--SGPNNL--EPFFE-SYISFLRRQLDLALG
ERGSLEGELKN-MQVLVEDFKKK-YEDEINKRTA---AENEFVGLK--K---DVDGAYMN
KVELQAKVDSLTDELNFLRTLYEM-----ELSQMQSHVSDT----SVVLSMDNNRCLDLD
SIIA-EVKAQYEEIAQ-RSKAEAEALYQTK--LGELQTTAGRHGDDLKSTKSEIMELN--
RMIQRLRAE-I--ENVKK------------------------------------------
-----Q-HA--NLQAAIAEAEQ-RGEMAL-KDASAKL----EGLKAALQKAKDDMARLLR
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RMS-G
ECQSA---V--------SISVVSNVTST--------------------------------
---------SGSSGGSRGGFGGVSGS----NS--GG---YRGNS----------------
---------------SSRGSSGG-HRGSG-------------------SA-GS-------
----------------------------------------RLSGGGSSSV-----SQSGI
GSSSG--GI-QTTGGSGYKS----GGGGSTNIRFS----QIP------------------
------------------------------------------------------------
----------SSS-QHSSK-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
--------------------------------------------------------TM--
----NRQVCKK--SF-SSGSQGFSGRSAVVSG-----GSSR-M-SC---VARSGGA-S--
-----GG-------------------------ACGFR----SG---AGGFGSRSLYNLGG
N-KSISISVAG-GS-RTGGFGGGRS------SCGSGFGGGFGGGYGGGFGG---------
-GR--GMGGGFGGAGGFG--------GAG-------------------------------
-----------------------GP-GG--FPGGI------QEVTVNQSLLQPL----NV
EIDPQIGQ--VKAQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQQQGTNSI--TGTNNL--EPLFE-NYISSQRSYLDSILG
ERGRLDSELRN-MQDLVEDFKKK-YEDEINKRTA---AENEFVTLK--K---DVDATYMN
KVELQAKVDALMDEVNFLRTLYDM-----ELSQMQSHVSDT----SVVLSMDNNRCLDLD
SIIA-EVKAQYEEIAQ-RSKAEAEALYQTK--LGELQTTAGRHGDDLKSTKSDIMELN--
RMIQRLRAE-I--ENVKK------------------------------------------
-----Q-NA--NLQAAISEAEQ-RGEMAL-KDANAKL----QELQAALQQAKDDMARLLR
DYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RMS-G
ECQNA---V--------SIC----------------------------------------
----------------------------------------GG------------------
----------------------------------------A--------G--SGFGGS--
SGFGGSSGFGSG--------------SGFGG---------GSGFGGG-SG--FGGG-SSF
GSGSG--GR-CGVSGGGFSSG----SNRGGSVKFS----QSS------------------
------------------------------------------------------------
----------QRC-SK--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MIARQQGIR-----A-GSRGFSSGSAI-IGG----GKKV-AFSSAS---VSGGA----
-----------------------------------------GRCS-SGGFGSRSLYNFRG
N-KNISCGMAGSRQ-GA-GFGSAGG-----------FS----------------------
-------------TGGFG----------------AGFGVGGFG-----------------
---GGFGG----SFS--GRGGPGFP-VC--PAGGI------QEVTINQSLLTPL----SV
EIDPEIQK--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWKLLQQQTTTT----SSRNL--DPFFE-TYISALRKQIDALGN
EKSRLQSELKM-MQDSVEDFKTK-YEDEINKRTT---AENDFVVLK--K---DVDAAYMN
KVELDAKVDSLNDEINFLRVLYEA-----ELSQMQSHVSDT----SVVLSMDNNRDLDLD
SIIA-EVRAQYEEIAQ-RSKAEVEAWYQTK--VQQLQTSVDQHGDNLKSTKNEISELN--
RMIQRLRAE-I--ENVKK------------------------------------------
-----Q-CQ--ALQTSVADAEQ-RGEVAL-KDAYSKR----TELEAALQKAKEELARMLR
EYQELMSVKLALDIEIATYRKLLEGEE--------------------------C-RMS-G
ECQSAVSIS--------V---VGGSVSTGG------------------------------
---------------I---G---GG---------------------------LSIGG---
---GFGL------------------------GGGFGSG--SGSGFGF--S-GG-------
----VSGSSGGKIISSTT-LT-RRSQL---------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MST
KTTIR---------SQT-SHRGFPATSARVPG-----LNRS-GFSSVS-VCRSRGSG---
-----G-----------------------------S----GAVCG-GAGFGSRSLYGLGC
S-KRISIGGSGYGI-G-GGYGSLVG-----------------------------------
--------------GRFGFG----G-AGSAFGFSG---------------------G---
-----------AGFGV-GYGGAGFP-VC--PPGGI------QEVTINQNLLTPL----NL
QIDPTIQR--VRTEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWALLQEQGTKT----VRQNL--EPMFE-QYISNLRRQLDSILG
ERGRLDSELRN-MQDTVEDFKNK-YEDEINRRTT---AENEFVTMK--K---DVDAAYMN
KVELQGRADSLADEINFLRTVFDA-----ELSQMQTHISDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEEIAQ-RSRAEAESWYQTK--VSTELECRSPR--------SEF------
----------------VF------------------------------------------
-----A-CK--TSHTCSL------SDGDS-RGLRNKL----EGLEDALQKAKQDMARLLK
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLY-G
EG-VGP--V--------N---ISV-VQSTV------------------------------
------------SSGYGS----AGGA----SS----------------------------
---SLG--------------------------------------LGGGSS----YSYSSS
--HGLG-----------------------------------------------------G
GFSSG--SG-RGIS--GGLSSSGGSSST---IK-Y----TTT------------------
------------------------------------------------------------
----------SSS-RKSY-----------------RH-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------ELQVTAGRHGDDLRNTKQEIAEIN--
RMIQRLRSE-I--DHVKK------------------------------------------
-----Q-CA--NLQAAIAEDEQ-RGEMAL-KDARGKL----EGLEDALQKAKQDMARLLK
EYQELMNVKLALDVEIATYRKLLEGEECR---------------------------LY-G
EG--VG-QV-------N-ISVVQSTV----------------------------------
------------SSSYGSAGGA--------------------------------------
---------------------------------------SSSLGLGGGSS----Y-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
H-------------F---SSPVFTSRSAAFSGR----GAQV-RLSSA----RPGG-----
----------------------------------------------LG-S--SSLYGLG-
------------AS-RPRVAV--RS-----------------------------------
---------------AYG------------------------------------------
----------------G-------P-----VGAGI------REVTINQSLLAPL----RL
DADPSLQR--VRQ EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-LLETKWTLLQEQKSA-----KSSRL--PDIFE-AQIAGLRGQLEALQV
DGGRLEAELRS-MQDVVEDFKNK-YEDEINRRAA---AENEFVVLK--K---DVDAAYMS
KVELEAKVDALNDEINFLRTLNET-----ELTELQSQISDT----SVVLSMDNSRSLDLD
GIIA-EVKAQYEEMAK-CSRAEAEAWYQTK--FETLQAQAGKHGDDLRNTRNEISEMN--
RAIQRLQAE-I--DNIKN------------------------------------------
-----Q-RA--KLEAAIAEAEE-RGELAL-KDARAKQ----EELEAALQRAKQDMARQLR
EYQELMSVKLALDIEIATYRKLLEGEE--------------------------S-RLA-G
D-------G--------VGA-----VN---------------------------------
-ISVMNST-GG-----SSSG----------------GGIGLTLGG-----TMGSNALSFS
SS-----AGPGP------------------------------------------------
--------LKAYSIRTASASRRSARN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
-------------------------------MT------QRSS---VTIKSGGTRNF---
-------------------SASSASLLPGCRPG----FSSV-SVSQS----G--------
---------------------------------------KSFGGGIGGGFGTRSLHSFGG
N-KRISIGGGYRST-R-ASFGGAAC-----------------------------------
---------------GLGVS-------GIGYRVGG-------------------------
------------AYGGYGYGGGMAP-----GAGGI------HEVTVNQSLLTPL----HL
EIDPSLQR--VRK EEKEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWSLLQEHKTT-----RT-NL--EPMFE-AYITNLRRQLECLGG
ERSRLETELKS-MQDVVEDFKNK-YEEEIHRRTA---AENEFVVLK--K---DVDAAYMN
KVELEAKVEALMDEINFLRAFFEA-----ELAQLQAQISET----SVVLSMDNNRSLNLD
SIIA-EVKAQYEDIAN-RSRAEAESWYQTK--YEELQRSAGQRGDDLRTTKMEISELN--
RAMQRLRSE-I--DNLKK------------------------------------------
-----Q-CA--TLQASIADAEQ-RGELAL-KDAKNKL----AELEDALQKAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEE--------------------------C-RLT-G
EGVGA---V--------NISVVSSSGGTGYSGGG--------------------------
-G----LC-VSGS-GYS-------------------GGGYSGSGLCYGGGG----SGGFS
STSGR-SVSGSS------------------------------------------------
--------SSMRIVSKTSSTKKSYRS----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------M--
----SRQASKI--S--GGGSQGFSGRSAVVSG------SSR-M-SS---VAWAGGA-G--
-----GG-------------------------ACGFR----SG---AGGFGSRSLYNLGG
N-KSISISVAAGGS-RAGGFGGGRS------S--YGFGGGYGGGFGGGYGSSFGGGFGGG
--R--GMGSGFGAAGGFG--------GASGFGGA-----GGFGGAGGFGGPGGFGGPGSF
GGPGGF---------G---P------GG--FPGGI------QEVTINQSLLQPL----NV
EIDPQIGQ--VKAQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQQQGTSSI--SGTNNL--EPLFE-NHINYLRSYLDNILG
ERSRLDSELRN-MQDLVEDFKKK-YEDEINKRTA---AENEFVTLK--K---DVDTAYMN
KVELQAKVDALLDEIDFLRTLYNA-----ELSQMQSHVNDT----SVVLSMDNNRSLDLD
SIIA-EVRAQYEDIAQ-RSKAEAEALYQTK--LGELQTTAGRHGDDLRNTKSEIIELN--
RMIQRLRAE-I--ENVKK------------------------------------------
-----Q-NA--NLQTAIAEAEQ-RGEMAL-KDANAKL----QELQAALQQAKDDLARLLR
DYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RMS-G
ECPSA---V--------SISVVSSGS----------------------------------
-------ATSASGGGYGGGYGG-------------GLGG----GF---------------
--------------------GA----G-------------AGSGFGRGGG--GGIGG---
---GFGFGG--------------GSSS--------------------SSG--F-SGGSGF
GSGSG--AR-YGVSGGGFSS----ASNRSGSIKLS----QSS------------------
------------------------------------------------------------
----------Q----RYSR-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----LEQQNK-VLEIKWNLLQQ-QQT-----ACSNM--DSMFE-SYINNLRRQLDTLG-
-------ELGN-TQWLVEDFKNK-YEED-NKHTE---MENECVLIK--K---DVDEAYMN
KVELESHLDGLTDEINFLRQLYQV-----EIRELQSQISDM----SVVLSMDNNCSLDMD
SIIA-EVRAQYKEITN-CSLAEAESVYQTT--YEELQVQAGKHGDDLWCMKTEVSDMN--
RNISRAKAE-T--EALKG------------------------------------------
-----Q-RA--SLEASITDAEQ-CGELAL-KDGNTKL----AQLEAALHQAKQDMAQQLD
EYQDLMNVKLALNVEFTTYCKLLEGEES---------------------------RLE-S
---GM---H--------NVSIHRKTTSG--------------------------------
---------------YSG---------------------GLSS-----------------
---ACG------------------------------CLTTLGLSYGLS--------FF--
--------------------------------QP--------GFGSGG---------SST
SFSHT-------------------SCRAVV------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
-------------------------------MA------QRSS---VTIKSGGTRNF---
-------------------SASSASLLSGCRPA----FSSV-SVSQS----G--------
---------------------------------------KCFGGNFGGGFGTRSLHSMGG
S-KRISVSGGYRSS-R-GSFGGAAC-----------------------------------
---------------GLG---------GIGYRMGG-------------------------
------------AYGGYGFGGPGVP-----GAAGI------QEVTVNQSLLTPL----HL
EIDPSLQR--VRK EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWSLLQEHKIT-----RT-NL--EPMFE-AYITNLRRQLDSLGG
ERGRLETELKN-MQDVVEDFKNK-YEEEINRRTA---AENEFVVLK--K---DVDAAYMN
KVELEAKMDALVDEINFLRAFYEA-----ELAQLQAQISET----SVVLSMDNNRNLDLD
SIIA-EVKSQYEDIAN-RSRAEAESWYQTK--YEELQRSAGRHGDDLRTTRTEISELN--
RAIQRLRSE-I--ENLKK------------------------------------------
-----Q-CA--SLQAAIADAEQ-RGELAL-KDAKNKL----AELEEALQKAKQDMARQLK
EYQELMNVKLALDIEIATYRKLLEGEE--------------------------C-RLT-G
EGVGA---V--------NISVVSSSGGTGYSGGG--------------------------
-G----LC-VGGG-GYS-------------------G----GSGLCYS-----GGSSGFS
STSGR-SVSGSS------------------------------------------------
--------SSMRIISKTSSTKKSYRS----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

MTSEGVF---------SDILSRYEKDGPVPKAKPRDVSDFSLYAPATKPCCS--------
------------------------SAYKRPGLGPAL--TSWPP----ALLEAPA---RSP
APMIARQQGAR-------GSRAFSCGSAV-VGG----GRRA-AFSSAS---VSGGA----
-----------------------------------------GRCS-SGGFGSRSLYSLGG
R-KSISMSVAGARQ-GA-GFGAAAG-----------FGAGS-------------------
-------FG-------------------------AGFGAGNFG-----------------
---SGFGG----SFS--GRGGPGFP-VC--PAGGI------QEVTINQSLLTPL----HV
EIDPEIQK--VRTEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWSLLQQQTTTT----SSKNL--EPLFE-AYISALRKQLDTLVN
DKGRLQSELKT-TQDSVEDFKTK-YEDEINKRAA---AENDFVVLK--K---DVDAAYMN
KVELEAKVDALNDEINFLRVLFAA-----ELSQMQTHVSDT----SVVLSMDNNRDLDLD
SIIA-EVRAQYEEIAQ-KSKAEAEALYQTK--VQQLQISVDQYGDNLKNTKNEISELN--
RMIQRLRAE-I--ENVKK------------------------------------------
-----Q-CQ--TLQASVADAEQ-RGELAL-KDAQSKY----KELEAALHQAKEELARMLR
EYQELLSVKLALDVEIATYRKLLEGEE--------------------------S-RMS-G
ECQSA---M--------SISVVGGIASAGG------------------------------
---------------IS-GG---LGS----C---SGFG--LGS-----------------
---------------------------------GFGSG--SGSGFGF--G-GG-------
----VCGSSGSKIVSTTTLTKR--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTQKSYK--VST--SGPWAFSSCSYMSGPG-----ARI-SFSNF-------------
-------------------------------------------------------PRVGS
S----------------------------------SFRGG------------LGTGY---
--------------A---------------------------------------------
------------------GVSGM-------GMGGI------TAVTINQSLLNPL----NL
EVDPNIQA--VRT QEKEQIKTLNNKFVPF------IDK--VW------------------
----FLEQQNK-MLETKWSLLQQ-QEM-----ARSNM--DNMFE-SYINNLRRQLETLGQ
EKLKLEAELGN-MQRLAEDFKNK-YEEEINKRTE---MENEFVLIK--K---DVDEAYMN
KVELESRLEGLTDEINFLRQLYEE-----EIRELQSQISDM----SVVLSVDNSCSLDMD
SIIA-EVKAQYEEIAN-CSPAEAESIYQIK--YKELQMLTGKHGDDLRHMKTEISEMN--
RNISQLQAE-I--EGLKG------------------------------------------
-----Q-RA--SLEAAIADVDQ-RGDLAL-KDACAKQ----QELEITLQWAKQDMAWQLH
EYQELMNVKLALDIEITTYRN---------------------------------------
--------------------IHMKTTSG--------------------------------
---------------YVG---------------------GLSS-----------------
---AYG------------------------------GLTSPGLSYSLG------------
---------------------------------S--------SFGSGM---------GPS
SVSCT-------------------SSTKAMVVKKI------ETRDGKLVSESSDILPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTQKSYQ--VS--TYGPQAFSSRSYTSAPG-----AHI-SSSSF-------------
-------------------------------------------------------SWVGN
S----------------------S-----------SFRGK------------PG------
------------------------------------------------------------
-----------------YQHG----------VGGI------TAVTVNQNLRSPL----KL
EVDPNTHA--VCI QEKEQIKSLN-KFDSF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQQ-QKT-----SRSNM--DNMFE-SYINNLRRQLEALGQ
EKLKWEAELGN-MQGLVEDFKTK-YEDEINKCTE---LENDFVLIK--K---DVDEAYMN
KVELESRLEGLTDKINLLRLIHEE-----EIRELQSQISDT----SVVLSMDNSHSLDMD
SIIA-EVRAQYEDIAN-CSPAEAESMYQIK--YEELQTLTGKHGDDLRRSKTEISEMN--
RNISRLQAE-I--EGLKG------------------------------------------
-----P-KA--MLEAAIADAEQ-RGEMAI-KVANAKL----AQLETALQ---QDMARQLR
EYQELMNVKLALDI----YRKLLEGEES---------------------------RLE-S
---RM---Q--------NLSTHTKTTSG--------------------------------
---------------YSG---------------------GLSS-----------------
---AYG------------------------------GFTSPGFSYGMS--------SF--
--------------------------------QP--------GFSSVG---------GSS
TYSH----------------------TKAVVVKKI------ETRDGKLVSESSDILPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------M--
----NRQVRKT--S--GGGSQGFSGRSAVVSG------SSR-M-SC---VARSGGA-G--
-----GG-------------------------AYGFR----SG---AGGFGSRSLYNLGG
N-KSISISVAG-GS-RAGGFGGGRS------S--CV------SGFGSGYGGGYGGGFGGG
--R--GMGGGFGA-GGFG--------GAGGFGG-----------------------AGGF
GGPGGFGGPG--GF-G---PGGFGP-GG--FPGGI------QEVTVNQSLLQPL----NV
EIDPQIGQ--VKTQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWSLLQQQGTHPI--TGTNNL--EPLFE-NYISSLRSHLDSILG
ERGRLDSELRN-MQDLVEDFKKK-YEDEINKRTA---AENEFVTLK--K---DVDAAYMN
KVELQAKVDALTDEINFLTTLYDM-----ELSQMQSHVSDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEEIAQ-RSKAEAEALYQTK--LGELQTTAGRHGDDLKSTKSEISELN--
RMIQRLRAE-I--ENVKK------------------------------------------
-----Q-IA--KLQSAVAEAEQ-RGELAL-KDANAKL----QELQAALQQAKDDLARLLR
DYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RMS-G
ECPSA---V--------SILIIRFKAASIASQSSWAQGIVMIWRRGG-WG-----RSAVL
LVSPPTGTTSASAGGFGGGYGG-------------GVGVGGG------------------
------------------------------------------------------------
---------------------------------------------V-RSG--F-GGGSGF
GXGSG--GR-SAVSGGGVSSS---SSSRGGSVRFS----QSS------------------
------------------------------------------------------------
----------QRT-SR--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------MSFSQV-SVKKHH----SGSGGG--
GRGG--------------------------FSACSLGAI-GGGSRSGGSYGSRSVYNLGG
K-SRTSISAASTRS-MAGGLGSAA---------GGGFGSAAG--------GGFGSAA---
-------------GGGFGGGAG----GGFGGGFGGGHGGG--------------------
--AGGMGGMGGPGFDG---GDMGFP-VC--PPGGI------QQVTINTQLLQPL----NL
TIDPNVQK--VKTEEREQIKTLNNKFAAY------IDK--VR------------------
----FLEQQNK-VLETKWKLLQEQGTKGS--TKRANL--EPLFE-KYIGDLNKYLSTLIN
EKDRLNQELKN-LQVLVEDYKKK-YEDEINKRTK---AENDFVLLK--K---DVDAAYMI
KTELEAKVDAVTSEINFLRTLYAA-----ELSQVHDSVTDT----SVVLTMDNNRDLNLE
GIIQ-EVKAQLELCAQ-RSKMEAEALFDNK--YKELQKTAEGHGDSIKNSKSEIAELN--
RRIQRLKAE-I--ENIKK------------------------------------------
-----Q-IA--GLNQSIAGAEE-KGNLAL-KDAEKKL----QDLEAAEKKLKEDMARQLK
EYQELLAAKIALDVEIGTYGLMLGGEE--------------------------H-RMS-G
DIVS-N--F--------SISVISGGASVYS------------------------------
------------ALGAAAGGM-GGG------M-----GG--------------GMGG---
---GMGGG-----------GMGGGMGSG---------------------H-GGGYGHGGG
F------------------------GSGH-GGG--------------------------F
GAGHG--AG-H-------GGGHGAGHGGKTSVAIA----STT------------------
------------------------------------------------------------
----------STS-KTSY------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------MSFSQV-SIKKRQ-TVSSGGGGG--
GRGG--------------------------FSACSLGAI-GGGSRAGGSYGSRSVYNLGG
K-SRTSISAASARS-MVGGLGSAA---------GGGFGGGAG--------GGFGGGA---
-------------GGGFGGGAG----GGFGGGFGGGHGGGMFGGAGGMGGMGGMGGMGGM
GGMGGMGGMGGPGFDG---GDMGFP-VC--PPGGI------QQVTINTQLLQPL----NL
TIDPNVQK--VKTEEREQIKTLNNKFAAY------IDK--VR------------------
----FLEQQNK-VLETKWKLLQEQGTKGS--TKRASL--EPLFE-KYIGDLRRYLDTLTN
EKARLLQELKN-LQDLVEEYKKK-YEDEINKRTK---AENDFVVLK--K---DVDAAYMI
KTELEAKVDAVTSEINFLRTLFAA-----ELSQVHDSVTDT----SVVLTMDNNRDFNLE
GIIQ-DVKAQLELAAQ-RSKMEAEALYDNK--YKELQRTAEGHGDSIKNSKTEIAELN--
RRIQRLRAE-I--ENIKK------------------------------------------
-----Q-IA--GLNQSIAGAEE-KGNLAL-KDAEKKL----QDLEAAEKKLKEDMARQLK
EYQELLAAKISLDVEISTYGLMLGGEE--------------------------G-RMS-G
EIAN-N--V--------SISVISGGSSVYS------------------------------
------------ALGGAAGGM-GGG------M-----GG--------------GMGG---
---GMGMGGGMGMGVGMGGGMGGGMGGG---------------------M-GGGMGMGGG
M------------------------GSAC-GYGQ------GMGG---------------M
GFEGG--SM-H-------GGSSYGHSGGKTSVAIA----STT------------------
------------------------------------------------------------
----------STT-KKTY------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MCM
R--VTQKSYK--VST--SGPRAFSSHSYTSGPG-----AHI-SSSSF-------------
-------------------------------------------------------SRVGS
S----------------------------------CFRGG------------LGGGY---
--------------G---------------------------------------------
------------------GASG---------VGGI------TAVTVSQSLLSPL----VL
EVDPDIQA--VCT QEKEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWSFLQQ-QKT---------------------------------
EKLKLEAELGN-MQGLVEDFKYK-YEDEINKRAE---MENEFVLIK--K---DVDEAYMN
KVELESRLEGLTDEINFLRQLYEE-----EIWELQSWISDT----SVVLSMDNSRSLDMN
SIIA-EVKAQYEEIAN-RSQAEAESMYQMK--DEELQSLAGKHGDNLRCTKTKISEMN--
WNISRLQAE-N--EGLKG------------------------------------------
-----Q-RA--FLEAAIADAEQ-CGELAI-KD-----------LEAALQRAKQDMAWQLR
EYQELMNVRLALDIEIATYKKLLEGEES---------------------------RLE-S
---GM---Q--------NMSIHTKTTSS--------------------------------
---------------YAS---------------------GLSS-----------------
---AYG------------------------------GLTSPGLSYGLG--------S---
---------------------------------S--------SFS---------------
R---T-------------------SSSRAVVVKKI------ETRDGKLVSESSDVLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
K--TTRVTYR--TSSAAPRSGGFSSYSYSGAPA-----ASR-ASTAS-------------
-------------------------------------------------------FSLGS
S------------------YGGSS-----------IGGSR------------FGSGY---
--------------R---------------------------------------------
---------------SGFGGAGV-------GSAGI------TAVSVNQSLLAPL----NL
EIDPTIQQ--VRTEEKEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQN-QKA-----TRSNM--DAMFE-AYIGNLRRQLDGLGQ
DKMRLESELGN-MQGLVEDFKNK-YEDEINKRTE---LENEFVLLK--K---DVDEAYMN
KVQLEARLEALTDEINFLRQLYEE-----ELRELQSQISDT----SVVLSMDNNRSLDLD
GIIA-EVRAQYEDIAN-KSRLEVESMYQVK--YQELQASAGRHGDDLKNTKAEISELT--
RYTTRLQSE-I--DALKA------------------------------------------
-----Q-RS--NLEAQIAEAEE-RGELAL-KDARTKL----AELEAALKNAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEES---------------------------RLE-S
---GF---Q--------NLSIQTKTVSG--------------------------------
---------------VSSG-----------------YGGGISS-----------------
---GYG------------------------------GGISSGYGGGISSGYGGGYSSY--
--------------------------------SS--------NVS--S---------LPL
ETSKT--------------------SKRSIVVKTV------ETKDGRVLSESSDVFSKP-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------MNGDLLLVGPPASSPASTMSI
R--VTQKSYK--VST--SGPRAFSSRSYTSGPG-----ARI-SSSSF-------------
-------------------------------------------------------SRVGS
S----------------------------------SFRGG------------LGGGY---
------------------------------------------------------------
-------------------GGAS-------GMGGI------TAVTVNQSLLSPL----NL
EVDPNIQA--VRT QEKEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQQ-QKT-----ARSNM--DNMFE-SYINNLRRQLETLGQ
EKLKLEAELGN-MQGLVEDFKNK-YEDEINKRTE---MENEFVLIK--K---DVDEAYMN
KVELESRLEGLTDEINFLRQLYEE-----EIRELQSQISDT----SVVLSMDNSRSLDMD
SIIA-EVKAQYEEIAN-RSRAEAESMYQIK--YEELQSLAGKHGDDLRRTKTEISEMN--
RNISRLQAE-I--EGLKG------------------------------------------
-----Q-RA--SLEAAIADAEQ-RGELAI-KDANAKL----SELEAALQRAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEES---------------------------RLE-S
---GM---Q--------NMSIHTKTTSG--------------------------------
---------------YAG---------------------GLSS-----------------
---AYG------------------------------GLTSPGLSYGLG------------
--------------------------------SS---------FGSGA---------GSS
SFSRT-------------------SSSRAVVVKKI------ETRDGKLVSESSDVLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--M-SRQSTVT--FHTG-SRRGFSVASATTPA-----HGRS-RFSSVS-MVRPAG--AGG
GLGRVS--------------------------GH------------GAAFGSRSLYNLGG
T-KRVSVGGC-GSS-----FRSG-------------FGG--RV----GSGFGV-----S-
--------------SGFGCG-----GGGF-------------------------------
--------------GGPGFP------AC--PSGGI------QEVTVNQSLLTPL----NL
QIDPTIQR--VRKEEKEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWSLLQEQGTR----TVRQNL--EPLFD-AYINDLRRQLDSITN
ERGRLDAELRN-MQDVVEDFKVR-YEDEINKRTA---AENEFVALK--K---DVDAAYMN
KIELEAKVHSLTDETNFFRMLFEA-----ELAQMQTQVSDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEDIAN-RSRAEAESWYQTK--YEELQVSAGRHGDDLRNTKQEISEMN--
RMIQRLRAE-I--DNVKK------------------------------------------
-----Q-CG--SLQTAIADAEQ-RGELAL-KDARAKL----VDLEEALQKAKQDMARLLR
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------S------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------MSIHFSSRSTAYPGR----GAQV-RLSSG----RA-S-----
----------------------------------------------FGS---RSLYGLG-
------------SS-RPRVAV--RS-----------------------------------
---------------AYG------------------------------------------
----------------G-------P-----VGAGI------REITINQSLLAPL----SV
DIDPTIQQ--VRQ EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWALLQEQKSA-----KSSQL--PRIFE-AQIAGLRQQLETLQL
DGGRLEVELRN-MQDVVEDFKNK-YEEEINRRTA---AENEFVLLK--K---DVDAAYTN
KVELEAKADSLQDEINFLKTLHET-----ELAELQSQISDT----SVVLSMDNSRSLDLD
GIIA-DVKAQYEEMAN-HSRAEAEAWYQTK--FETLQAQAGKHGDDLRNTRNEIAEMN--
RSIQRLQAE-I--DTLKN------------------------------------------
-----Q-RA--KLESSIAEAEE-QGELAI-KDAHAKQ----GELEAALQKAKQDVARQLR
EYQELLNTKLALDIEIATYRKLLEGEE--------------------------S-RLS-G
DGMGP---V--------NISV---------------------------------------
----VNS----------TGG----------------NGGKLIFGG-----TMGSNALSF-
-S-----GGPGA------------------------------------------------
--------LRAYSIKTTSTTRRGTHN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--M-SRQSSIT--FQSG-SGRGFSTTSATTPA-----TGRS-RFSSVS-VARSAA--GSG
GLGRIS--------------------------SA------------GASFGSRSLYNLGG
A-KRVSISGC-GSS-----FRSG-------------FGG--RA----SNGFGV-----N-
--------------SGFGYG--GGVGGGF-------------------------------
--------------SGPSFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPTIQR--VRA EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQSSR----TVRQNL--EPLFD-SYISELRRQLESLTT
ERGRLEAELRN-MQDVVEDFKVR-YEDEINKRTA---AENEFVALK--K---DIDAAYMN
KVELEAKVKSLPEEINFLHSVFDA-----ELSQLQTQVSDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEDIAN-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEISEMN--
RMIQRLRAE-I--DSVKK------------------------------------------
-----Q-CS--SLQTAIADAEQ-RGELAL-KDARAKL----VDLEEALQKAKQDMARLLR
EYQELMNIKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VS-PVNIS--------VVSSTL----------------------------------
------------SSGYGSGS--GIG-----------------------------------
---------------------------------------GGSLGLGGGSG----YSFTT-
-----------------------SG-------GHSLG--A--GLGG-------------S
GFSAT---SNRGLGG------------SGSSVKFV----STTS-----------------
------------------------------------------------------------
------------SSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
----------------------------------------------------------MR
-SSVSRQTYST--------KGGFSSNSASGG---AGAGTRT-SFSSVT-VSRSSGSGGG-
--------------------------A--------------HCGPSTGGFGSRSLYNLGG
H-KSISVSVAGGASAG-RAL----------------------------------------
--------------GGFGFG------------------SRAFT-----------------
-------GLG-------TGRQTFGP-AC--PPGGI------QEVTVNQSLLTPL----HV
EIDPEIQR--VRTQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQGQNLG--GTRNNL--DPLFE-AYLGNMRGMLDRLQG
ERGRLDSELRN-VQDLVEDFKNK-YEDEINKRTA---AENEFVVLK--K---DVDAAYMG
QMDLQGKMGTLTQEIDFLQQLYEM-----ELSQVQTHVSDT----NVVLSMDNNRNLDLD
SIIA-EVKAQYELIAQ-RSRAEAEAWYQTK--YEELQVTAGKHGDNLRDTKNEIAELT--
RTIQRLQGE-V--DAAKK------------------------------------------
-----Q-CQ--QLQTAIAEAEQ-RGEMAL-KDAKNKL----EGLEDALQKAKQDMARLLK
EYQELMNVKLALDVEIATYRKLLESEE--------------------------S-RMS-G
ECPSA---V--------SISVTGNSTTVRG------------------------------
-----------------GG--------------AAGFGGGISLGGS---GG--ATKGGFS
TN----------------------------------------VGYST----------I--
KGGPISG--GTSILRKT--TTVKTSSRRC-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
----------------------------------------------------------MR
-SSLSRKTYAT--------KGGFSSNSASGG---RGSRTHT-SFSSTT-MSRSSSSGGG-
--------------------------V--------------HCGPRMGGFGSRSLYNLGG
S-KSISVSMA---SSG-RGL----------------------------------------
--------------GGFGLG------------------SGPYG-----------------
-------GLG-------AGKQTFGP-VC--PPGGI------QEVTVNQSLLTPL----NV
EIDPEIQR--VRT QEREQIKILNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQGQTRG--VTRNNL--EPLFE-IYVNGLRRTLENYQG
ERGRLDSELKN-VQEGLEDFKNK-YEDEINKRTA---LENEFVVLK--K---DVDAAYMA
KTELQGTVESLQQEIDFRHRLYEL-----ELSQVQTHVSDT----NVVLSMDNNRNLDLD
SIIA-EVKAQYELITQ-RSRAEAEAWYQTK--YEELQVTAGKHGDNLRDTKNEIAELT--
RTIQKLQGE-T--DAAKK------------------------------------------
-----Q-CQ--QLQEAIAESEE-RGELAL-KDAKKKL----GDLDAALHQAKEDLARLLS
DYQALLNVKIALDVEIATYRALLESEE--------------------------S-RMS-G
ECPSA---V--------SISVTGNSTTVCG------------------------------
-----------------GS--------------AAGFGGGISLGGG---VG--ASKGGFS
TN----------------------------------------MGCGT----------V--
KGGP-SG--GTSILRKT--TTVKTSSRRY-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSTKTTIR--SQ--TSHRGFSAGSARVPG-----LNRS-GFSSVS-VSRSRGSGGSG
A-------------------------------VC-----------GGAGFGSRSLYGVGS
S-KRISIGGG----SC--GIGGG-------------YGS--RV----GGGFGFGGGA-S-
--------------SGFGFG--GG--A------GS-----------------GF----GF
G--SG-AGFGG-GYGGAGFP------VC--PPGGI------QEVTINQSLLTPL----NL
QVDPTIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWALLQEQGTK----TVRQNL--EPLFE-QYISNLRRQLDGVLG
ERGRLDSELRS-MQETVEDYKNK-YEDEINKRTA---AENEFVTLK--K---DVDAAYMN
KVELQAKTDSLTDEINFLRVLYDA-----ELSQMQTHISDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEEIAQ-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKEEIAELN--
RMIRRLQAE-I--ENLKN------------------------------------------
-----Q-IA--NLQAAIAEAEQ-RGENAL-KDARGKL----EGLEDALQKAKQDMARLLK
EYQELMNVKL-----IATYRKLLEGEE--------------------------C-RLN-G
EG--VG-PV-------N-ISVVQSTM----------------------------------
------------SSGYGSAG-------------------GA--S----------------
----------------------------------------SGLGLGGG-S----SYSYS-
-------------------------SS--------------HGLG--------------G
GFSSG---SGRGLS--GGLS--SSGGS-SSTIKYT----TTS------------------
------------------------------------------------------------
------------SSRKSYRH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTQKSYK--VS--TSGPRSFSSRSYTSGPG-----TRI-SSSAF-------------
-------------------------------------------------------SRVGS
S----------------------G-----------SFRGG------------LGS-----
---------------SYS------------------------------------------
-----------------GAPG----------LGGI------TAVTVNQSLLSPL----KL
EVDPDIQA--VRTQEKEQIKTLNNKFASF------IDK--VR------------------
----HLEQQNK-ILETKWNLLQQ-QKT-----ARSNI--DNMFE-SYINNLRRQLETLAQ
EKLKLEVELGN-MQGLVEDFKTK-YEEEIQKHTD---MENEFVIIK--K---DVDEAYMN
KVELESRLEGLTDEINFYRQLYEE-----EIREMQSQISDT----SVVLSMDNSRSLDLD
GIIA-EVXXXXXXXXX-XXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXXXXXXXX--
XXXXXXXXX-X--XXXXX------------------------------------------
-----X-RA--SLEAAIADAEQ-RGELAV-KDAQAKL----AELEAALRTAKQDMARQLR
EYQELMNVKLALDVEIATYRKLLEGEES---------------------------RLE-S
---GM---Q--------NMSIHTKTTSG--------------------------------
---------------YSG---------------------GLTS-----------------
---PYG---------------------------------NPGFNYGLS--------SY--
--------------------------------QS--------SLGSGG---------GSG
SFSRT-------------------S-SKAVVVKKI------ETRDGKLVSESSDILPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSV
Q-------------F---SAQTFSSRSAAFPRR----GAQG-LLSSG----ASRGG----
---------------------------------------SAS---HMGAFGSSSLYGLG-
------------SG-RPRVSVGFRS-----------------------------------
------------------------------------------------------------
-------------------GGGFGV-----KGAGI------HEVTINQSLLAPL----NV
EIDPQIQQ--VRKEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQEQKSS-----KGSSL--PSIFE-AHIANLRRQLDGLQG
DRGRLESELKN-MQDVVEDFKTK-YEDEINKRTA---AENEFVMLK--K---DVDSAYMT
KVELDAKVDALMDEINFLRTLYEM-----ELNELQNQISDT----SVVISMDNRRNLDLD
SIID-EVKAQYEDIAN-RSRAEAESWYQTK--CEEMKATVIRHGESLRRTKEEINELN--
RMIQRLTAE-V--ENAKC------------------------------------------
-----Q-NS--KLEAAVTQSEQ-QGEAAL-NDARCKL----AGLEEALQKAKQDMACLLK
EYQEVMNSKLGLDIEIATYKRLLEGEE--------------------------Q-RLCEG
V--GA---V--------NVCVSSSRGGVVCGDLC-----------------------TST
SGARVVST-GST------GP----------------SGGSVVVSA---------------
---PNACAPCGV------------------------------------------------
--------GSGYSTRSCATSCGVRRC----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
MS--STSTTIR--SH-SSSRRGFSAGSARLPG-----VSRS-GFSSVS-VSRSRGSGGLG
G-------------------------------AC-----------GGAGFGSRSLYNLGG
S-KRISIGGG----SC--AISGG-------------YGS--RA----GGSYGFGG-A-G-
--------------SGFGFG--GG--A------GI-----------------GF----GL
G--GG-AGLAG-GFGGPGFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPTIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVRQSL--EPLFE-QYINNLRRQLDSIVG
ERGRLDSELRG-MQDLVEDFKNK-YEDEINKRTA---AENEFVTLK--K---DVDAAYMN
KVELQAKADTLTDEINFLRALYEA-----ELSQMQTHVSDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEEIAQ-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEISEIN--
RMIQRLRSE-I--DHVKK------------------------------------------
-----Q-CA--NLQAAIADAEQ-RGEMAL-KDAKNKL----EGLEDALQKAKQDMARLLK
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLN-G
EG--VG-QV-------N-ISVTQSTV----------------------------------
------------SSGYGGSSG-------------------------V-------------
---------------------------------------GGGLGLGGGSG----YS----
-----------------------YGSG--------------LGVG--------------G
GFSSG---SGRVIG--GGLS--SVGGG-SSTIKYT----TSSS-----------------
------------------------------------------------------------
------------SSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQCA----VRS-QGRAACSAASAFLP-------------SLRP-APRAGGSGG--
-------------------------------------TPGHGRFPG--VFGSRSLHGLG-
C-QRISVAGRGGA----F-Y--GP------------------------------------
--------------AGFGAG------TGISCGFGGA------------------------
---------VA-GPFG-FGGGPGFP-AV--PAGGI------HEVSVNQSLLKPL----NL
EIDPNIQS--IRKDEKDQIQTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQGNKT----VRKDI--EPLFE-TYLNNLRRHLSSLMT
DRENLGGELSK-MQSLAEDFKNK-YEEELNKRAA---VESDFVTLK--K---EVDTAYLD
KTELQARLDSLTEEIDFLRALYEA-----ELSQVQTQISDT----SVVLTMDNSRSLDLD
SIIS-EVKAQYEEIAN-RSRAEAEAWYQSR--YEELQATAGRHGDDLRSTKQEISELN--
RHVQRLRSE-I--DSVKK------------------------------------------
-----Q-VA--GLQTAIADAEQ-RGELAL-KDARAKL----AELEDALQQAKADLARQLR
EYQELMNVKLALDIEIATYRKLLEGEE--------------------------S-RLS-G
EGAG-S--V--------NISVTRTTS----------------------------------
----------------GTGHGSGNCL----S-----------------------------
------------------------------------------------------------
----------------------------F-SG--------GAAGGVCAGM--------GT
GSISG--AG-H-STGGSCM-VG----GSSSSFKST----SSS------------------
------------------------------------------------------------
----------SSS-RRCY------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQSSVS--FR-SGGSRSFSTASAITPS-----ISRT-SFTTV---SRSGGG-GGG
GFGRVS--------------------------LG-------GACGV-GGFGSRSLYNLGS
S-KRISFSAG----GG--GFRSR-------------FGAG--A----GGGYGFGGGA-G-
--------------SGFGFG--GGAG--------G-----------------GF----GL
G--GGA-GFGG-GFGGPGFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPAIQR--VRTEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVRQNL--EPLFE-QYINNLRRQLDGILG
ERGRLDSELRN-MQDLVEDFKNK-YEDEINKRTT---AENEFVMLK--K---DVDAAYMN
KVELEAKVDALMDEINFMKMFFDA-----ELSQMQTHVSDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEEIAN-RSRTEAESWYQTK--YEELQQTAGRHGDDLRNTKHEISEMN--
RMIQRLRAE-I--DNVKK------------------------------------------
-----Q-CA--NLQNAIADAEQ-RGELAL-KDARNKL----AELEDALQKAKQDMARLLR
EYQELM-TKLALDVEIATYRKLLEAEE--------------------------C-RLS-G
EG--VG-PV-------N-I-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQSSVS--FR-SGGSRSFSTASAITPS-----VSRT-SFSSV---SRSGG----G
VGGRVS--------------------------LG-------VA-GGAGGYGSRSLYNLGG
T-KRISISAS----GG--GFRNR-------------FGGGAGS----G--FGFGGGA-G-
--------------SGFGFG--GGAG-G------------------------GF----GL
G--GGAGFG-G-GYGGAGFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPTIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTR----TVKQSL--DPLFE-QYINNLRRQLDSIVG
ERGRLDSELRN-MQDLVEDFKNK-YEDEINKRTT---AENEFVMLK--K---DVDAAYMS
KVELEAKVDALMDEINFMKMFFDA-----ELSQMQTHVSDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEDIAN-RSRTEAESWYQTK--YEELQQTAGRHGDDLRNTKHEISEMN--
RMIQRLRAE-I--DNVKK------------------------------------------
-----Q-CA--NLQAAIADAEQ-RGELAL-KDARNKL----AELEDALQKAKQDMARLLR
EYQELMNTKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VG-PV-------N-ISVVTNSM----------------------------------
------------SSGYGGGS--GFGG----G---SGFGG--SLSGGLGSG----L-----
-----G----------------------------------------GGGS----SSYYS-
-----------------------SSSG-----GVGLG--SGLSVGG-------------S
GFSSS---SGRGVGVGFGS----GGG-SGSSVKFV----STTS-S---------------
------------------------------------------------------------
-------------SRRTFKS----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
----------------------------------------------------------MM
-SSRSRQTYTT--------KGGFSSNSASGG---GGSRART-SFSSVT-VSRSSGSGGG-
--------------------------T--------------RRGPSMGGFGSRSLYNLGG
N-RSISVSVAGAATSG-RGL----------------------------------------
--------------GGFGLG------------------SGAFV-----------------
-------GLG-------AGRQTVGP-VC--PPGGI------QEVTINQSLLTPL----NV
EIDPEIQR--VRT QEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNQ-VLETKWALLQEQGQNSG--ATRSSL--EPLFE-AYLSSLRNTLGHLQN
ERGRLDSELRN-VQDLVEDVKSK-YEDEINKRTA---AENEFVVLK--K---DVDAAYMG
RMDLQGRGDNLTQEIDFLRQIYEM-----ERSQVQTHVSDT----NVVLSMDNNRNLDLD
SIIA-EVKAQYELIAQ-RSRAEAEAWYQTK--YEELQVTAGKHGDNLRDTKNEIAELT--
RTIQRLQGE-A--DAAKK------------------------------------------
-----Q-CQ--QLQTAIAEAEQ-RGELAL-KDAKKKL----GDLDVALHQAKEDLARLLR
DYQDLMNVKLALDMEIATYRKLLESEE--------------------------S-RMS-G
ECPST---V--------SISVTGNSTTVCG------------------------------
-----------------GG--------------AAGFGGGISLGGS---GG--ASKGGFG
TS----------------------------------------GGYST----------V--
KGGLASG--GTSILRKT--TTVKTSSRRY-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSM
R-V-TQKSYK--VST--SGPRAFSSHSYTSGLA-----PAS-APPAS-------------
-------------------------------------------------------P-ERA
A----------------------A-----------AASGR------------PGA-----
------------------------------------------------------------
---------------GWL-WRGG-------GVGGI------TAVQVNQSLLNPL----NL
EVDPNIQA--VRI QEKEQIKNLNNKFASF------IDK--VR------------------
----FLEPQNK-MLETKWSLLQW-QKT-----SRSNM--DNMFE-SYINNLRRELDTLGQ
EKLKLEAELGN-TQGMVEDFKNK-YEDEINKRTE---MENEFVLIK--K---DVDEAYMN
KVELESRLEGLTDEINFLRQLYEE-----EIRELQSQISDT----SVVLSMDNSRSLDLD
GIIA-EIKVQYEEIAN-RSRAEVESMYQIK--YEELQTLAGKHGDDLRRTKSEISEMN--
RSISRLQAE-I--EALKG------------------------------------------
-----Q-RA--ALEAAIANAGQ-RGEMAI-KDANAKL----AQLESALQKAKQDMAQQLR
EYQELMNVKLALDIEIATYCKLLEGEEN---------------------------RLE-A
---GM---Q--------NLSIHTKTTSG--------------------------------
---------------YAG---------------------MVSS-----------------
---PCG------------------------------GLTSPGFGSLTS------------
---------------------------------P--------------------------
GF--T-------------------RTKSAVVVKKI------ETRDGKLVSETSDVLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTQKSYK--VST--SGPRAFSSRSYTSGPG-----ARI-SSSSF-------------
-------------------------------------------------------SRVGS
G----------------------S-----------SFRGG------------LGTSM---
--------------GL---G----------------------------------------
---------------GGF-GA-A-------GVGGI------TAVTVNQTLLSPL----KL
EVDPNIQA--VRT QEKEQIKSLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQQ-QKT-----ARSNM--DNMFE-SYINNLRRQLEALGQ
EKLKLEAELGN-MQGLVEDFKNK-YEDEIHKRTE---MENEFVLIK--K---DVDEAYMN
KVELESRLEGLTDEINFLRQIHEE-----EIRELQSQISDT----SVVLSMDNSRSLDME
SIIA-EVRAQYEDIAN-RSRAEAESMYQIK--YEELQTLAGKHGDDLRRTKTEISEMN--
RSINRLQAE-I--DALKG------------------------------------------
-----Q-RA--SLEAAIADAEQ-RGEMAV-KDANAKL----SELEAALHRAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEES---------------------------RLE-S
---GM---Q--------NLSIHTKTTSG--------------------------------
---------------YSG---------------------GLNS-----------------
---AYG------------------------------GLTSPGFGYGVSSF-------Q--
--------------------------------PG---------FGSAG---------SSS
TISRT----------------------KAVVVKKI------ETRDGKLVSESSDILPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSV
R--VTQKSYK--VS--TSGPRASSSHSYMSGPG-----DHI-SSLSF-------------
-------------------------------------------------------SQVGS
-----------------------S-----------SFRGG------------LGG-----
---------------GYG------------------------------------------
-----------------GASG----------MGGI------TAITVSRRLLSPL----NL
EMDPNIQA--VHT QEKQQIKTLNNKFASF------IDK----------------------
--------LNK-MLETKWSLLQQ-QKT-----AQSNM--DNMFE-SYINNLRRQLKTLGR
EKLKLEAELGN-MQGLVEDFKNK-YEDENHKRAE---VENEI------------------
-VELESRLEGLPDEINFLKQLYEE-----EIWELQSQISDT----SVVLSMDNSLSLGMN
SIIS-EVKAPYEEIAN-S-----ESMYQIK--YEELQTLAGKHKDDLWCTETEISEMN--
RNIS--------------------------------------------------------
-----H-RA--SLEARIADAEQ-RGELAF-KDANAKL----SELEVSLQRAKQDMAWQLL
EYQELMNVKLALDIEIATYRKLLEGEES---------------------------WLE-S
---GM---Q--------NMSIYTKTTSS--------------------------------
---------------YAG---------------------GLNS-----------------
---AYG------------------------------GLTSP-------------------
------------------------------------------RFGSGV---------GST
SFSCT-------------------STTRAVFSSDI------LPK----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
-----------------------------------------------KSPAQTAKTTMM-
--------AT--SV--CIHPTGFSSCSYSSGPG-----ACI-SSSF--------------
--------------------------------------------------------SW-V
G---------------------SG-----------SFPSG------------LGTGL---
--------------CLGG------------------------------------------
-----------------GYARAG-------GMGGI------TAVTVNQNLLSPL----NL
EVDPNIQA--MCPQEKEEIKTLNNKFASF------IDK--VR------------------
----FLEQRNK-MLETRWNLLQQ-QKT-----AHSNM--DSLCE-SYINKLPRQLDTLGQ
EKLKLEAELGN-MQGLVEDFKNK-YEE-IN-KTE---MENESVLIR--K---DVDEGW--
-VELESRLDGLTDEISFLRLLYEE-----EIRELQSQISDM----SVVLSMDNSRSL-MD
SIIA-EVRSQYEGIAI-HSWAEAESVYQTK--YKELQMQAGKHG----RTKTEISNMN--
LNISRLQNE-T--EALQG------------------------------------------
-----Q-RA--AVEASIADAKQ-HRELAV-KDANAKL----AQLEAALGQAKQDIAQQLR
EYQDLMNVKLALDVEITTYHKLLEGKES---------------------------QLE-S
---GM---Q--------NLSIHTKTTSG--------------------------------
---------------YSG---------------------GLSS-----------------
---AYG------------------------------GLTSLGLSYGLS--------SF--
--------------------------------QT--------VFGSGG---------GSS
SFSHT----------------------QAVVVKKI------ETRDGKLVSESFDVPPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
H-------------F---SSPVFTSRSAAFSGR----GAQV-RLSSA----RPGG-----
----------------------------------------------LG-S--SSLYGLG-
------------AS-RPRVAV--RS-----------------------------------
---------------AYG------------------------------------------
----------------G-------P-----VGAGI------REVTINQSLLAPL----RL
DADPSLQR--VRQ EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-LLETKWTLLQEQKSA-----KSSRL--PDIFE-AQIAGLRGQLEALQV
DGGRLEAELRS-MQDVVEDFKNK-YEDEINRRAA---AENEFVVLK--K---DVDAAYMS
KVELEAKVDALNDEINFLRTLNET-----ELTELQSQISDT----SVVLSMDNSRSLDLD
GIIA-EVKAQYEEMAK-CSRAEAEAWYQTK--FETLQAQAGKHGDDLRNTRNEISEMN--
RAIQRLQAE-I--DNIKN------------------------------------------
-----Q-RA--KLEAAIAEAEE-HGELAL-KDARAKQ----EELEAALQRAKQDMARQLR
EYQELMSVKLALDIEIATYRKLLEGEE--------------------------S-RLA-G
D-------G--------VGA-----VN---------------------------------
-ISVMNST-GG-----SSSG----------------GGIGLTLGG-----TMGSNALSFS
SS-----AGPGP------------------------------------------------
--------LKAYSIRTASASRRSARN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--IMSCQSTVR--FQ-RSGRSGFSANSAITPG-----INRS-GFSSVS-VCRTGGSGGFG
R-------------------------------SC-------GIS-GGAGFGSRSLYNLGG
S-KRIAIAGS----SS--GFQSG-------------YGG--RM----GGGFGFGSG----
--------------------------V------SG-----------------GF----GY
G--GG-AGFGG-GYGGAGFP------VC--PPGGI------QEVTINQSLLTPL----NL
QIDPTIQR--VKTEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVKQNL--EPMFE-AYINQLRGQLDRITR
EKGSLDSELRN-MQDQVEDFKNK-FEDEINKRTA---AENEFVTLK--K---DVDAAYMN
KVELQAKADSLLEDINFLRAFYEA-----ELAQMQTHISDT----SVVLSMDNNRSLDLN
SIIA-EVKAQYEEIAQ-RSRAEAESWYQTK--YEELRITAGRHGDDLRNTKHEISEMN--
RMIQRLRAE-I--DSVKK------------------------------------------
-----Q-CA--NLQNSIAEAEQ-KGEMAL-KDAKAKL----EDLEAALQRAKQDMARQLR
EYQELMNVKLSLDIEIATYRKLLEGEE--------------------------C-RMS-G
EG--VG-QV-------N-ISVVSSSV----------------------------------
------------SSGYGSGSG-----------------------SGV-------------
---------------------------------------GGGFGMGGGSG----YS----
-----------------------YGSG----SGYNVG--GGLSVG--------------G
GFSSG---SGR--------G--SLGGS-STSVKYT----TTT--S---------------
------------------------------------------------------------
------------SSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
----------------------------------------------------------MR
-SSMSPWIYST--------KGGFSSSSASGG---GGSRTHT-SFSSVT-MSRNSGSGGG-
--------------------------A--------------RCEPSTGGFGSRSLYNLRG
S-KSISASVAAGASLG-QAQ----------------------------------------
--------------GGFALS------------------GGACM-----------------
-------GLG-------AGRQTFVP-TC--PPGGI------QEVTVNQNLLTPL----NV
EIDPQIQR--VRTQEREQIKTLNNKFASF------IDK--VG------------------
----FSRAFSKDIDSTKWALLQEQGQNTG--VHR--L--EPLFE-SYLGNLRRQLDSLQS
ERGRMDSELRN-VQDLLEDFKNK-YEDEINKRTA---VENEFVVLK--K---DVDAAYMG
RMDLHGKVGILADEVVFLQHLYEM-----ELSQVQTHVSDT----NVVLSMDNNRNLDLD
SIIA-EVKAQYELIAQ-RSRAEAESWYQTK--YEELRVTAGKHGDNLRDTKNEIAELT--
RTVQRLQGE-V--DAVKK------------------------------------------
-----Q-CQ--QLQMAITEAEQ-RAEVAL-KDAQKKL----GDLAVALHQAKEDLVRLLR
DYQALMNVKLALDVEIATYRTLLEGEE--------------------------S-RMS-G
ECQSA---V--------SISVTGNSTTVSR------------------------------
-----------------GC--------------SAGFGGGISLSGG---V--GRIKGGFS
PN----------------------------------------VGYSS----------A--
KGRGVSG--GTSILQKT--TTVKTSSRRY-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------GTK----TVRHNL--EPLFE-QYINNLRRQLDSITG
ERGRLDSELRG-MQDMVEDYKRK-YEDEINKRTA---AENEFVTLK--K---DVDAAYMN
KVELQARADSLRDEINFLRAFYDA-----ELSQMQTHISDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEEIAQ-RSRAEAESWYQTK--YEELQITAGRHGDDLRNTKQEIAEIN--
RMIQRLRSE-I--DHVKK------------------------------------------
-----Q-CA--NLQAAIADAEQ-RGELAL-KDARSKL----EGLEDALQKAKQDMARLLK
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VG-PV-------N-ISVMQSTI----------------------------------
------------SSGYGSAG-------------------GA--S----------------
----------------------------------------SGLGLGGS-G----SYSYS-
-------------------------SG--------------HNLG--------------G
GFSSS---SGRGIG--SSLS--TSGGS-TSTIKYT----T-TS-----------------
------------------------------------------------------------
------------SSRKSYRH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQSSVS--FR-SGGSRSFSTASAITPS-----VSRT-SFTSV---SRSGG--GGG
GFGRVS--------------------------LG-------GAYGA-GGYGSRSLYNLGG
S-KRISISTS----GG--SFRNR-------------FGAG--A----GGGYGFGGGA-G-
--------------SGFGFG--GGAG--------G-----------------GF----GL
G--GGA-GFGG-GFGGPGFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPSIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVRQNL--EPLFE-QYINNLRRQLDSIVG
ERGRLDSELRN-MQDLVEDFKNK-YEDEINKRTT---AENEFVMLK--K---DVDAAYMN
KVELEARVDALMDEINFMKMFFDA-----ELSQMQTHVSDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEEIAN-RSRTEAESWYQTK--YEELQQTAGRHGDDLRNTKHEISEMN--
RMIQRLRAE-I--DNVKK------------------------------------------
-----Q-CA--NLQNAIADAEQ-RGELAL-KDARNKL----AELEEALQKAKQDMARLLR
EYQELMNTKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VG-PV-------N-ISVVTSSV----------------------------------
------------SSGYGGGS-G--------------YGS--GLGGGLGGG----------
------------L--------------------------GGGLG-GGGSG----SYYSS-
------------------------SSG-----GVGLG--GGLSVGG-------------S
GFSAG---SGRSMGVGFGS---GG-G-SSSSVKFV----STTS-S---------------
------------------------------------------------------------
-------------SRKSFKS----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQSSVS--FR-SGGGRSFSAASAVTPS-----VSRT-SFTSV---SRSGG--GGG
GFGRIS--------------------------LG-------GGACGAGGFGSRSLYNVGS
G-KRLSTTS-----IS--SFRNR-------------YVPG--A----GGSFGFGGAS-G-
--------------SGFGFG--GGAGGG-------------------------L----GL
G--GG-AGFGG-GFGGAGFP------VC--PPGGI------QEVTINQSLLTPL----NL
QIDPTIQR--VKTEEREQIKTLNNKFASX------XXX--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVKQNL--EPLFE-QYINNLRRQLDSILG
ERGRLDSELRN-MQDLVEDFKNK-YEDEINKRTT---AENEFVMLK--K---DVDAAYMN
KVELEAKVDALMDEINFLKLFFEA-----ELAQMHTHISDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEDIAN-RSRTEAESWYQTK--YEELQQTAGRHGDDLRNTKHEISEMN--
RMIQRLRAE-I--DNVKK------------------------------------------
-----Q-CA--NLQAAIADAEQ-RGELAL-KDARNKL----SELEDALQKAKQDMARLLH
DYQELMNVKLSLDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VG-PV-------N-ISVVTNSV----------------------------------
------------SSSYGGG---------------SGFGG--GLGGGLGGG----L-----
-----GGGGS---------------------------------------G-----IYYS-
-----------------------SSSG-----GLGMG--SGLSVGG-------------S
GFSGN-----SGLGLGFGSS--GGGG-SSSSVKFV----STTS-S---------------
------------------------------------------------------------
-------------SRKSFKS----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQSSVS--FR-SGGSRSFSTASAITPS-----VSRT-SFTSV---SRSGG--GGG
GFGRVS--------------------------LG-------GAYGA-GGYGSRSLYNLGG
S-KRISISTS----GG--SFRNR-------------FGAG--A----GGGYGFGGGA-G-
--------------SGFGFG--GGAGGGF-G----------------------------L
G--GGA-GFGG-GFGGPGFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPGIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVRQNL--EPLFE-QYINNLRRQLDSIVG
ERGRLDSELRN-MQDLVEDFKNK-YEDEINKRTT---AENEFVMLK--K---DVDAAYMN
KVELEARVDALMDEINFMKMFFDA-----ELSQMQTHVSDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEEIAN-RSRTEAESWYQTK--YEELQVTAGRHGDDLRNTKQEISEMN--
RMIQRLRAE-I--DSVKKQVKFWQGQELLKCSFLLGHSAIFKNSSPRSITPPWAVSRIHG
FLLSLQ-CS--SLQTAIADAEQ-RGELAL-KDARAKL----VDLEEALQKAKQDMARLLR
EYQELMNIKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VS-PV-------N-ISVVSSTL----------------------------------
------------SSGYGSGS-G--------------IGG--GSLG---------L-----
-----------------------------------------------GGG----SGYSF-
-----------------------TTSG-----GHSLG--AG--LGG-------------S
GFSAT---SNRGL----------G-G-SGSSVKFV----STTS-S---------------
------------------------------------------------------------
-------------SRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
----------------------------------------------------------MR
-SSVSRQTYST--------KGAFSSSSASGA---GGSRART-SFSSVT-VSRNSGSGGG-
--------------------------P--------------RCGPSMGGFGSRSLYNLGG
S-KSISVSMAGGASAG-RVL----------------------------------------
--------------GGFGLG------------------GGAYM-----------------
-------GLG-------AGRPMLGP-VC--PPGGI------QQVTVNQSLLTPL----HV
EIDPEIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQGQKSG--VTRNNL--EPLFE-SFINNLRGKLDNLQS
ERGRLDSELRN-VQDLAEDFKTK-YEDEINKRTA---AENEFVVLK--K---DVDASYMG
RMDLHGTVDRLVEEMDFLRHLYEE-----ELSQVQTHVSDT----SVILSMDNNRNLDLD
SIIA-EVKAQYEQIAQ-RSRAEAESWYQTK--YEELQVTAGKHGDNLRDTKNEIAELT--
RTVQRLQGE-A--DAVKK------------------------------------------
-----Q-CQ--QLQTAIMDAEQ-HGELAL-KDAQKKL----GDLDAALYQAKEDLARLLR
DYQALMNVKLALDVEIATYRKLLESEE--------------------------G-RMS-G
ECPSA---V--------SISVIGNSTTVCG------------------------------
-----------------GG--------------VAGFGGGITLGGG---GG--ASKGRFS
TS----------------------------------------AGYST----------V--
KGGPVSG--GTSILRKT--TTVKTSSRRY-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MIAKQQCVR-----G-GSRGFSCGSAI-VGG----GKRV-AFSSGS---VSGGA----
-----------------------------------------GRCS-SGGFGSRSLYNLGG
H-KSISLSVAGSRQ-GA---GGAGG-----------FGAGGFG-----------------
-------------AGG--------------------FGAGGFG-----------------
---SGFG-----------WGGSGLA-AC--PAGGI------QEVTINQSLLTPL----HV
EIDPEIQK--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLVTKWNLLQQQTTTT----SSKNL--DPFFE-TYINALRKQLDTLAN
EKGRLQSELKV-MQDSVEDFKTK-YEDEINKRTT---AENDFVVLK--K---DVDAAYMT
KVELEAKVDGLNDEINFLRVLFEA-----ELSQIQSHVSDT----SVVLSMDNNRNLDLD
SIIA-EVRAQYEDIAQ-RSKAEAEALYQVK--VQQLQNSVDQHGDNLKNTKNEISELN--
RLIQRLRAE-I--ENVKK------------------------------------------
-----Q-CQ--TLQASVADAEQ-RGELAL-KDAYTKR----TELETALQKAKEELARMLR
EYQELLSVKLALDIEIATYRKLLEGEE--------------------------C-RMS-G
ECQSA---V--------SISVVGGSSSIGG------------------------------
--------------------------------------------------------I---
---GISL------------------------GSGFGSC--SGGGFGF--G-SG-------
----VCGSSGSKIISTTTLGKKPRE-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MNRQACKT--TF-SSGGRGFSGRSAVVS-G-----SSR-M-SC---VARSGGASG--
-----AG-------------------------ACGFR----SGAGGAGGFGSHSLYNLGG
T-KSISCSVA-AGS-RAGGFGGGRS------SYG----SGFGGG----YGGGFGGGLGGG
--R--GMGGGFG-------------------------------GAGGFVGAGGXXXXXXX
XXXXXXXXXX--XXXX---XXXXXX-XX--XXXXXXXXXXXXXXXXXXXXXXXX----XX
XXXXXXXX--XXXXXXXXXXTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQQQGTNSI--TGTNNL--DPLFE-NYISSQRSYLDGVLG
ERGRLESELRN-MQDLVEDFKKK-YEDEINKRTA---AENEFVTLK--K---DVDAAYMA
KVDLQAKVDTLIDEINFLRALYDM-----ELSQMQSHVSDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEDIAQ-RSKLEAESLYQTK--LGELQSTAGRHGDDLKSTRSEIMELN--
RMIQRLQAE-I--ENVKK------------------------------------------
-----Q-NA--NLQAAIAEAEQ-RGELAL-KDANAKL----QELQAALQQAKDDLARLLR
DYQELMNVKLALDVEIATYRKLLEGEE--------------------------CSRMS-G
ECQSA---V--------SI-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------MSIHFSSRSTAFPGR----GAQM-RLSSG----RAGG-----
----------------------------------------------FGS---SSLYGLG-
------------TS-RPRMAM--RS-----------------------------------
---------------AYG------------------------------------------
----------------S-------P-----MGSGI------REITINQNLLAPL----RL
DIDPTIQQ--VRQ EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWVLLQEQKSA-----KGSKL--PRIFE-AQIAGLRQQLETLQL
DGGRLEAELRS-TQDMVEDFKNK-YDEEINRRTA---AENEFVLLK--K---DVDAAYMN
KVELEGKVDGLNDEISFLKTLNET-----ELEELQSQISDT----SVVLSMDNSRSLDLD
GIIA-DVKAQYEAMAK-NSRAEAEAWYQTK--FETLQAQAGRHGDDLRNTRNEIAEMN--
RTIQRLQAE-I--DAVKN------------------------------------------
-----Q-RA--KLEASIAEAEE-HGELAL-KDAHAKQ----EELEAALQQAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEE--------------------------S-RLS-G
SGIGP---V--------NISV---------------------------------------
----VNS----------TGG----------------SGSRLVFDG-----TMGSNALRFS
SS-----GRLGG------------------------------------------------
--------LKAHSIRTTSTSHRSPHN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MNRQVCKK--SF-SGGSQGFSGRSAMVS-G-----SSR-M-SC---VARSGGA-S--
-----GG-------------------------ACGFR----SGA---GGFGSRSLYNLGG
N-KSISISVATGGS-WAGGFGGGRS------SCG--FGGGYGSG----FGGSYGGGFGGG
--R--GVGSGFG-------------------------------GAGG------F------
GGPGGFGGPG--SFGS---PGGFGP-GG--FPGGI------QEVTVNQSLLQPL----NV
EIDPQIGQ--VKA QEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWELLQQQTTGSG--SGPRSL--EPCFE-SYISFLRKQLDSLLG
EKGNLEGELKN-MQDLVEDFKKK-YEDEINKRTA---AENEFVGLK--K---DVDAAFMN
KVELQAKVDSLTDEVSFLRTLYEM-----ELSQMQSHVSDT----SVVLSMDNNRCLDLD
SIIA-EVRAQYEEIAE-RSKAEAEALYQTK--LGELQTTAGRHGDDLRNTKNEIMELN--
RMIQRLRAE-I--ENVKK------------------------------------------
-----Q-NA--NLQTAVAEAEQ-RGEMAL-KDANTKL----QDLQAALQKAKDDLARLLR
DYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RMS-G
ECQSA---V--------CISVVSNVTST--------------------------------
---------NGSSGSSRGIFGGVSGS----GS--GGYRGGSSSS----------------
-------------------SSSG-YG-VSG---------GSSSG-YGGVS-IG---SA--
GGRGSSGGYQ--------------------TSSS------GSRLSGAGSIS---GGHSGK
GSSSD--SI-QTSGGSGYKS----GGGGSTNIRFS----QTT------------------
------------------------------------------------------------
----------SSS-QHSSTK----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTQKSYK--VS--TSAPRAFSSRSYSSGPG-----ACI-SSSSF-------------
--------------------------------------------------------SR-V
G---------------------SG-----------SFQNG------------LGTSL---
--------------GLSG------------------------------------------
-----------------GYAGAG-------GMGDI------TAVTVNQSLLSPL----NL
EVDPNVQA--VHTQEKEKIKILNNKFASF------IDR--VR------------------
----FLEQQNK-RLETKWNLLQQ-QQT-----ARSNM--DSMFE-SYINNLRPQLDTLGQ
EKLKLEAELGN-MQGLVEDFKSK-YE-EISKCTE---MENGFVLIR--K---DVDE-YMN
QVELESHLEGLFDEITSSGSCM-K-----RSPEMQSQISDT----SVVLSMDNSRSLDMD
SIIA-EVRARYEEIAN-CSQAETESVYQTK--YEELQCQAGKHGDNLRHTKTEISDMN--
WNISQLQNE-I--GAPKG------------------------------------------
-----Q-RA--SLQAAVMDAEQ-CGELAV-KDANAKLAQRLAQLEAALHQAKQDMAQQLY
EYQDLMNVKLALGMEIATYRKLLEGKES---------------------------RLE-S
---GM---Q--------SMSIHTETTSG--------------------------------
---------------YSG---------------------GLSS-----------------
---AYG------------------------------GLASPDLSYGLS--------SF--
--------------------------------QT--------GFGSGG---------GSS
FFSRP--------------------SSRAVVVKMI------ETQDGKLVSESSDALPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQACKK--SF-SSGSQGFSGHSAVVS-G-----SSK-M-GG---VFRSGGA-G--
-----GG-------------------------ACGFR----GGA---GGFGSRSLYNLGG
H-KSTSISVAAGGS-QAGGFG-RWS------SCG--FGGGYGGG----F----GGGFGGG
--R--GMGGGFG-------------------------------GAGGFGGAGGF------
GGAGGFGGPG--GFGG---PGGFGP-GG--FPGGI------QEVTVNQSLLQPL----NV
EIDPQIGQ--VKA QEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWELLQQQTVGSG--SGPSSL--EPLLE-SYIGFLRKRLDSLLG
ERGPLEGELKN-MQDLVEDFKKK-YEDEINKRTA---AENEFVGLK--K---DVDVAYMN
KVELQAKVDALTDEINFLRTLHEM-----ELSQMQSHVSDT----SVVLSMDNNRCLDLD
SIIA-EVRAQYEEIAQ-RSKAEAEALYQTK--LGELQSTAGRHGDDLRSTKSEIMELN--
RMIQRLRAE-I--ENVKK------------------------------------------
-----Q-NA--NLQAAIAEAEQ-RGELAL-KDANAKL----QDLQAALQKAKDDLARLLR
DYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RMS-G
ECQSA---V--------SISVVSNVTNT--------------------------------
---------SSSVGGSRGGYGGVGGS--------SGYRGGSGSSS---------------
---------------------------------------RGSSG-YGGVG-GD---SS--
GDRGSSGGYQ--------------------SGGS------GSRLGGVGGSS---GSQGGL
GSGSG--SV-QTSGGSGYKS----GSGGSISIRFS----QTS------------------
------------------------------------------------------------
----------SSS-QHGSK-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
----------------------------------------------------------MR
-SSLSRQTYST--------KGGFSSNSAGGG---GGSRTHT-SFSSVT-MSRSSGSG---
------------------------------GI---------RCGPSSGGFGSRSLYNLGG
--KNIS---------G-GAL----------------------------------------
--------------GGFGFG------------------SGAYV-----------------
-------GLG-------AGRQTFGP-VC--PPGGI------QEVTINQSLLTPL----NV
EIDPEIQR--VRT QEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEHSQKAG--VARSNL--EPLFE-THLSSLRRKMDAMHN
EQGRLDLELRS-VQDNLEDFKNK-YEDEINKRTA---LENEFVVLK--K---DVDAAYMG
RMDLHGKVESLSQEIEFLQHLYEM-----ELSQVQTHVSDT----NVVLSMDNNRSLDLD
SIIA-EVKAQYELIAQ-KSRAEAESWYQSK--YEELQVTAGKHGDSLRDTKNEISELN--
RTIQRLQGE-V--DAARK------------------------------------------
-----Q-CQ--QLQAAISEAEQ-HGEMAL-KDAKKKL----GDLDTALHQAKEDLARLLR
DYQALMSVKLALDVEIATYRKLLESEE--------------------------S-RMS-G
ECPST---V--------SISVTGNSTTVCA------------------------------
-----------------GG--------------TAGFAGGFSLGAG---GG--AGKGGFG
TS----------------------------------------VSYGT----------A--
KGGPVSG--GTSILRKT--TKVKTSSGRF-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------M--
----SRQASKT--S--GGGSQGFSGRSAVVSG------SSR-M-SY---VARSGGA-G--
-----GG-------------------------AYGFR----SG---AGGFGSRSLYNLGG
N-KSISISAAAGGS-RAGGFGGGRS------S--CGFAGGYGGGFGGGYGGGFGGGFGGG
--R--GMGGGFGGAGGFG--------GAGGFGGA-----GGFG------GPGGFGGPGSF
GSPGGF---------G---P------GG--FPGGI------QEVTINQSLLQPL----NV
EIDPQIGQ--VKAQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQQQGTSSI--SGTNNL--EPLFE-NHINYLRSYLDNILR
ERGRLDSELKN-MQDLVEDFKKK-YEDEINKRTA---AENEFVTLK--K---DVDSAYMN
KVELQAKVDALIDEIDFLRTLYDA-----ELSQMQSHISDT----SVVLSMDNNRSLDLD
SIIA-EVRAQYEDIAQ-RSKAEAEALYQTK--LGELQTTAGRHGDDLRNTKSEIIELN--
RMIQRLRAE-I--ESVKK------------------------------------------
-----Q-NA--NLQTAIAEAEQ-HGEMAL-KDANAKL----QELQAALQQAKDDLARLLR
DYQELMNVKLALDVEIATYCKLLEGEE--------------------------Y-RMS-G
ECPSA---V--------SISVISSST----------------------------------
--------TSASAGGYGGGYGG-------------GLGGGLGGGF---------------
--------------------GA----GGG-----------SGSGFGRGGG--GGI-----
-----GGGF--------------GGGS--------------------SSG--F-SGGSGF
GSVSG--AR-YGVSGGGFSS----ASNRGGSIKFS----QSS------------------
------------------------------------------------------------
----------QSS-QRYSR-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
----------------------------------------------------------MR
-SSVSRKTYST--------KGGFSSNSASGG---GGSQART-SFSSVT-VSRNSGSGGG-
--------------------------T--------------RCGPSTGGFGSRSLYNLGG
H-KSISVSVAGGASLG-RAL----------------------------------------
--------------GSFGFG------------------SRAFT-----------------
-------GQG-------AGRQTFGP-AC--PPGGI------QEVTVNQSLLTPL----HV
EIDPEIQR--VRTQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQGQNLG--ITRNNL--EPLFE-AYLGSMRSTLDRLQS
ERGRLDSELRN-VQDLVEDFKNK-YEDEINKRTA---AENEFVVLK--K---DVDAAYMG
RMDLHGKVGTLTQEIDFLQQLYEM-----ELSQVQTHVSDT----NVVLSMDNNRNLDLD
SIIA-EVKAQYELIAQ-RSRAEAEAWYQTK--YEELQVTAGKHGDNLRDTKNEIAELT--
RTIQRLQGE-V--DAAKK------------------------------------------
-----Q-CQ--QLQTAIEEAEQ-HGELAL-KDAQKKL----GDLDVALHQAKEDLARLLR
DYQELMNVKLALDVEIATYRKLLESEE--------------------------S-RMS-G
ECPSA---V--------SISVTGNSTTVCG------------------------------
-----------------G---------------------GISLGGN---GG--ATKAGFS
TN----------------------------------------VGYST----------I--
KGGLVSG--GTSILRKT--TTVKTSSRRY-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------GGFSSRSLYSLGG
T-KSTSLGGFGGAG-GAC------------------------------------------
--------------RGFGF--------GAGAGFGGGYGAGCFGGGP--------G-----
------SGFGG-GFDG-GMGGQGFP-PC--PPGGI------REVTINQSLLAPL----NL
EIDPEIQK--VRTQEREEIKKLNDKFASF------IDK--VR------------------
----FLEQQNR-VLETKWKLLQEQGGTG---TGSRNL--DPFFE-TYISGLRKQLDCLSS
EKLQLETELKS-FQDMVEDFKTK-YEEEINKRTA---AENEFVFSSHLQ---DVDGAYMT
KVELQGKLDSLSDEINFLKCLSEA-----ELSQMQQQVSDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEEIAN-RSRLEAESWYRCK--YEELQATAGKHGDSLKDTKIEISELN--
RVIQRIRAE-I--ESVKK------------------------------------------
-----Q-CE--TIQTSIADVEQ-RGEVAL-KDARDKL----AELETALQKAKTDMARQLR
EYQDLMNVKLALDVEIATYRKLLEGEE--------------------------C-RMS-G
ECQS-S--F--------SISVVGGSSSVGS------------------------------
------------GY--------GSGI----GMGGGF-GGGSGMGG-GMGGGGMCGGGSS-
--------------------------------------------FGGG------------
---------------------------IM-GGSC------GMGGGMYA-----------G
GFSSG--SG------RMCGSGG----GSSSVRRCV----TTT------------------
------------------------------------------------------------
----------S-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
----------------------------MNGVSWSQGL-QEGISAWFGPPASTPASTMSI
S--PTRCPPL--GP-----------RAFSS---------------RS-------------
------------------------------------------------------------
------------------------------------YTSG--------------------
------------------------------------------------------------
----------------------------------F------S------------------
-------R--VAAAEKEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQQ-QKT-----ARSNM--DNMFE-SYINNLRRQLETLGQ
EKLKLEAELGN-MQGLVEDFKNK-YEDEINKRTE---MENEFVLIK--K---DVDEAYMN
KVELESRLEGLTDEINFLRQLYEE-----EIRELQSQISDT----SVVLSMDNSRSLDMD
SIIA-EVKAQYEDIAN-RSRAEAESMYQIK--YEELQSLAGKHGDDLRRTKTEISEMN--
RNISRLQAE-I--EGLKG------------------------------------------
-----Q-VW--AGLG----------ELV--------------------------------
-----------LT---------PHLSGY---------------------------RLE-S
---GM---Q--------NMSIHTKTTSG--------------------------------
---------------YAG---------------------GLSS-----------------
---AYG------------------------------GLTSPGLSYGLG------------
---------------------------------S--------SFGSGA---------GSS
SFSRT-------------------SSSRAVVVKKI------ETRDGKLVSESSDVLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
----------------------------------------------------------MR
-SSVSRQTYST--------KGGFSSNSASGG---SGSRAHT-SS-SVT-VSRSSGGG---
-------------------------------S---------RSGPSMGGFGSRXXXXXXX
X-XXXXXXXXXXXXXX-XXX----------------------------------------
--------------XXXXXX------------------XXXXX-----------------
-------XXX-------XX--XXXX-XX--XXXXX------XXXXXXXXXXXXX----XX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXX------XXX--VR------------------
----FLEQQNK-VLETKWALLQEQSQNSG--VTRNNL--EPLFE-TYTGNLRRQLDNLQG
EQGRLDSELRN-MQDLVEDFKNK-YEDEINKRTA---AENEFVVLK--K---DVDAAYMG
RMDLHGKVGTLTEELDFLNHLYEM-----ELSQVQTHVSDT----NIVLSMDNNRNLDLD
SIIA-EVKAQYELIAQ-RSRAEAEAWYQNK--YEELQVSAGKHGDNLRDTKNEIAELT--
RTVQRLQGE-V--DAAKK------------------------------------------
-----Q-CQ--QLQTAIVDAEQ-RGNLAL-KDAQKKL----GDLDTALLQAKEDLARLLR
DYQALMNVKLALDVEIATYRKLLESEE--------------------------S-RMS-G
ECPSA---V--------SISMTGNSTTVSG------------------------------
-----------------GG--------------AAGFGGGISLGGS---GV--TGKGGFS
TS----------------------------------------VGYST----------V--
KGGPVSA--GTSILRKT--TTVKSSSRRY-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MNRQACKT--TF-SSGGRGFSGRSAVVS-G-----SSR-M-SC---VARSGGASG--
-----AG-------------------------ACGFR----SGAGGAGGFGSHSLYNLGG
T-KSISCSVA-AGS-RAGGFGGGRS------SYG----SGFGGG----YGGGFGGGLGGG
--R--GMGGGFG-------------------------------GAGGFGGAGGFGGPGGF
GGLGGFGGPG--GFGG---PG------G--FPGGI------QEVTINQSLLQPL----NV
GIDPQIGQ--VRTQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQQQTTGSG--SGPNNL--EPFFE-SYISFLRKQLDQAVN
ERGNLEGELKN-MEDLVEDFKKK-YEDEINKRTA---AENEFVGLK--K---DVDAAYMV
KVELQAKADSLTDEINFLRTLYEM-----ELSQMQSHVSDT----SVVLSMDNNRCLDLD
SIIA-EVKAQYEEIAQ-RSKLEAESLYQTK--LGELQSTAGRHGDDLKSTKSEIMELN--
RMIQRLRAE-I--ENVKK------------------------------------------
-----Q-NA--NLQAAIAEAEQ-RGELAL-KDANAKL----QSLQAALQQAKDDLARLLR
DYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RMS-G
ECQSA---V--------SISVVSNVTTS--------------------------------
---------SSSSAGSRGGFGGVSGS----SS--GG---YRGGS----------------
---------------SSRGSGSG-YGGTSG---------GSSSGGYGGIS-SG---SS--
RGRGSSGGYR--------------------GGSS------GSRGSSGGSISGGYGGPSGV
GSSSS--GI-QTSGSSGYNS----GSGGSSTIRFS----QTT------------------
------------------------------------------------------------
----------SSS-QHSTK-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTQKSYK--VST--SGPRAFSSRSYTSGPG-----ARI-SSSSY-------------
-------------------------------------------------------SRVGS
S----------------------------------SFRGG------------LGGGY---
------------------------------------------------------------
-------------------GGAS-------GMGGI------TAVTVNQSLLSPL----NL
EVDPNIQA--VRT QEKEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQQ-QKT-----ARSNM--DNMFE-SYINNLRRQLETLGQ
EKLKLEAELGN-MQGLVEDFKNK-YEDEINKRTE---MENEFVLIK--K---DVDEAYMN
KVELESRLEGLTDEINFLRQLYEE-----EIRELQSQISDT----SVVLSMDNSRSLDMD
SVIA-EVKAQYEEIAN-RSRAEAESMYQIK--YEELQSLAGKHGDDLRRTKTEISEMN--
RNISRLQAE-I--ESLKG------------------------------------------
-----Q-RA--SLEAAIADAEQ-RGELAI-KDANAKL----SELEAALQRAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEES---------------------------RLE-S
---GM---Q--------NMSIHTKTTSG--------------------------------
---------------YAG---------------------GLSS-----------------
---AYG------------------------------GLTSPGLSYGLG------------
--------------------------------SS---------FGSGA---------GSS
SFSRT-------------------SSSRAVVVKKI------ETRDGKLVSESSDVLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--M-SRQSSIT--FQSG-SRRGFSTTSATTPA-----TGRS-RFSSVS-VARSAA--GNG
GLGRIS--------------------------SA------------GASFGSCSLYNLGG
A-KRVSISGC-GSS-----FRSG-------------FGG--RA----SSGFGV-----N-
--------------SGFGYG--GGVGGGF-------------------------------
--------------SGPSFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPTIQR--VRA EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQGSR----TVRQNL--EPLFD-SYISELRRQLESITT
ERGRLEAELRN-MQDVVEDFKVR-YEDEINKHTA---AENEFVALK--K---DIDAAYMN
KVELEAKVKSLPEEINFLHSVFDA-----ELSQLQTQVSDT----SVVLSMDNSRNLDLD
SIIA-EVKAQYEDIAN-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEISEMN--
RMIQRLRAE-I--DSVKK------------------------------------------
-----Q-CS--SLQTAIADAEQ-RGELAL-KDARAKL----VDLEEALQKAKQDMARLLR
EYQELMNIKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VS-PVNIS--------VVTSTL----------------------------------
------------SSGYGSGS--GIG-----------------------------------
---------------------------------------GGSLGLGGGSG----YSFTT-
-----------------------SG-------GHSLG--A--GLGG-------------S
GFSAT---SNRGLGG------------SGSSVKFV----STTS-----------------
------------------------------------------------------------
------------SSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MIARQQSVR-----G-GSRGFSCGSAV-VGG----GKRV-AFSSAS---ISGGA----
-----------------------------------------GRCS-SGGFGSRSLYNLGG
H-KSISMSVAGSRQ-GI-GFGGAGG-----------FGTGSFG-----------------
-------------GA-------------------GGFGAGSFG-----------------
---GGFGG----SFN--GRGGPGFP-VC--PPGGI------QEVTINQSLLTPL----HV
EIDPEIQK--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQQQTTTT----SPRNL--DPFFE-TYLSALRKQLDTLLN
DKGRLESELKL-MQDSVEDFKTK-YEDEINKRTA---AENDFVVLK--K---DVDAAYMT
KVESEAKVDGLNDYINFLRVLYEA-----ELSQMQTHVSDT----SVVLSMDNNRNLDLD
SIIA-EVRAQYEDIAQ-RSKAEAEALYQTK--VQQLQTSADQYGDNLKSTKNEISELN--
RMIQRLRAE-I--ENVKK------------------------------------------
-----Q-CQ--TLQASVADAEQ-RGELAL-KDAYSKR----TELEAALQKTKEELARLLR
DYQALMNVKLALDIEIATYRKLLEGEE--------------------------C-RMS-G
ECQSA---V--------SISVVGGSASIGG------------------------------
---------------ISG-------------------------------------GF---
---GLG--------------------------SGFGSC--SGSGFGY--G-GG-------
----VSGSTGSKIISTTTLT--KRSQR---------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTQKSYR--VSN--SGPGAFSSRSFTSGPS-----ARS-SSSSF-------------
-------------------------------------------------------SRVSS
T----------------------------------GFRGG------------LGASY---
--------------A---------------------------------------------
------------------GASGI-------VMGGI------TAVTINQSLLNPI----KL
DVGPNIQA--VCT QEKEQIKTLNKKFASF------IDK--VW------------------
----FLEQQNK-VLETKWSLLQQ-QKT-----AGSNM--DNMFE-SYINNLRRQLETLGQ
EELKLEAELGN-MQGLVEDFQNK-YEEEINKHTE---MENEFVLIK--K---DVDEAYMN
KVELESRLEGLTDEINFLRQLYEE-----EIRELQSQISNT----SVVLSMDNSHSLDMD
SIIA-EVKAQYEEIAN-RSRAEAESVYQIK--YEELQKLAGKHGDDLRRTKTEISEMN--
RNISRLQAK-M--EGLKG------------------------------------------
-----Q-RA--SLEAAILDAEH-RGEQAL-KDALAKQ----QQLEEALQKAKQDMARQLR
DHQELMNVKLALDIEIATYRKLLEGEES---------------------------RLE-S
---GM---Q--------NMSIHTKTTSG--------------------------------
---------------YAG---------------------GPSS-----------------
---AYG------------------------------GLTSPGLSYGLG------------
---------------------------------S--------SFGSGA---------GS-
AFSRT-------------------SSIKAVVV-KI------ETRDGRLVSESSDVLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MNRQVCKT--S--GGRSQGFSGRSAVVSG------SSR-M-SC---VARSGGA-S--
-----GG-------------------------ACGFQ----SG---GGGFGSHSLYNLGG
N-KSICMSVAAGGS-RAGGYGGGRS------LCG----GGYGGGYGGGYGGGYGGGYGGG
MG---GYGAGFGGG------------------IG-----GGFGG--------------GR
GLGGGFG--------G---PGGFGP-GG--FPGGI------QEVTVNQSLLQPL----NV
EIDPQIGQ--VKTQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWTLLQQQGTNSI--TGTNSL--EPFFE-SYISSLRTRHDAIIG
ERGRLDSELRS-MQDLVEDYKKK-YEDEINKRTT---AENEFVTLK--K---DVDAAYMT
KVDLQAKADALLDEINFMTTLYDA-----ELSQMQRHISDT----SVVLSMDNNRSLDLD
SIIA-EVKAQXXXXXX-XXXXXXXXXXXXX--LGELQTTAGRHGDDLRNTKSEIMELN--
RMIQRLRAE-I--ENVKK------------------------------------------
-----Q-NA--NLQAAIGEAEQ-RGELAL-KDANAKL----QDLQDALQKAKDDLARLLR
DYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RIS-G
ECQSA---V--------SISVVSSGST---------------------------------
--------TSASAGGYGGG-YGGG------------FGGGSGF-----------------
--------------------GG----G---------------SGFGG-------------
---------GSGF-----------------------------G--GGSGF--G--SGSGF
GSGSG--GL-AGVSGGGFST----GSNRGGSIKFS----SSS------------------
------------------------------------------------------------
----------SSS-QRRS------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------GGFGSQSLYYLGS
K-NS--VSMTRGSLPR-RAL----------------------------------------
--------------GGFGLV------------------GGVYM-----------------
-------GLG-------AARQ-TGP-TC--PAGGI------QEVTVNQSLMTPL----NV
EIDPEIQR--VRTQEREEIKTLNNKFASF------IDK--VR------------------
----FLEQQNQ-VLETKWVLLQEQGQNSC--VTS-NV--EPLFQ-TFPGSLQGXXXXXXX
XXXXXXXXXXX-XXXXXXXXXXX-YKDEINKRTA---AENEFVVLK--K---DVDAAYIT
QVDLRGKIGILSEEVDFRRHLYDM-----ELSQVQTHMSDT----NVVLSMDNNRCLDLN
SIIA-EVKAQYEEIAQ-RSRTEAEALYQSK--YEELQVTAGKHGDNLRNTKNSIAELS--
RTVQRLQGE-A--DAARK------------------------------------------
-----Q-CQ--QLQTAIVEAEQ-HGELAL-KDAQRKL----GDLDVALHQAKEELARIVR
DYQDLMNTKLALDIEIVTYRKLLEGEE--------------------------S------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------MSIHFSSRSTAYPGR----GAQV-RLSSG----RA-G-----
----------------------------------------------FGS---SSLYGLG-
------------SS-RPRVAV--RS-----------------------------------
---------------AYG------------------------------------------
----------------G-------P-----VGAGI------REITINQSLLAPL----SV
DIDPTIQQ--VRQ EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWALLQEQKSA-----KSSQL--PRIFE-AQIAGLRQQLETLQL
DGGRLEVELRN-MQDVVEDFKNK-YEEEINQRTA---AENEFVLLK--K---DVDAAYTN
KVELEAKADSLQDEINFLKTLHET-----ELAELQSQISDT----SVVLSMDNSRSLDLD
GIIA-DVKAQYEEMAN-HSRAEAEAWYQTK--FETLQAQAGKHGDDLRNTRNEIAEMN--
RSIQRLQAE-I--DTLKN------------------------------------------
-----Q-RA--KLESSIAEAEE-QGELAI-KDAHAKQ----GELEAALQKAKQDMAQHLR
EYQELLNTKLALDIEIATYRKLLEGEE--------------------------S-RLS-G
DGMGP---V--------NISV---------------------------------------
----VNS----------TGG----------------NGGKLIFGG-----TMGSNALSF-
-S-----GGPGA------------------------------------------------
--------LRAYSIKTTSTTRRGTHN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MIARQQCVR-----G-GPRGFSCGSAIVGGI----KRH--AFSSAS---VSGGA----
-----------------------------------------GRCS-SGGFGSRSLYNLGG
N-KSISMSMAGSRQ-GA-CFGGAGG-----------FGTGGFG-----------------
------A-------GGLGA----------------GFGAAGFG-----------------
---GGFGG----SFS--GKGGPGFP-VC--PAGGI------QEVTINQSLLTPL----HV
EIDPEIQK--VRT EEREQIKILNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQQQTTTT----SSKNL--EPLFE-TYLSVLRKQLDTLVN
DKGRLQSELKT-MQDSVEDFKTK-YEEEIHKRTA---AENEFVVLK--K---DVDAAYMN
KVELEAKVDSLNDEINFLKVLYDA-----ELSQMQTHVSDT----SVVLSMDNNRCLDLD
SIIA-EVRAQYEEIAQ-RSKAEAEALYQTK--VQQLQVSVDQHGDNLKNTKSEIAELN--
RVIQRLRAE-I--ENIKK------------------------------------------
-----Q-CQ--TLQASVVDAEQ-RGENAL-KDAHSKR----IELEAALQQAKEELARMLR
EYQELMSVKLALDVEIATYRKLLESEE--------------------------C-RMS-G
ECPSA---V--------SISVVSGSTSTGG------------------------------
---------------IGG-G---FGS-----------------------------GS---
---GFGL------------------------SSGFGSG--SGSGFGF--G-GS-------
----VSGSSSSKIISTTTLNKRSPR-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSV
R-V-TQKTYK--VST--SGPRAFSSRSYSSAPG-----SRI-SSSAF-------------
-------------------------------------------------------SRVGS
-----------------------------------Y-RPG--------------------
---------------L---G----------------------------------------
---------------GGYGG-AG-------GAGNI------TAVQVNQSLLSPL----KL
EVDPNIQA--VRTQEKEQIKTLNNKFANF------IDK--VR------------------
----SLEQQNK-ILETKWNFLQQ-QKT-----IRSNM--DNMFE-SYINNLRRQLDTLAQ
EKLRLEAECGN-MQGLVEDLKNK-YEDEINKRTE---MENEFVLIK--K---DVDEAYMN
KVELESRLEGLTDEINFYRQLYEE-----EIRELQAQISDT----SVVLSMDNNRSLDLD
GIIA-EVKAQYEDIAN-RSRAEAETMYQIK--G-DLSSLTGKHGDDLRRTKTEISEMN--
RNISRLQAE-I--EALKG------------------------------------------
-----Q-RA--SLEAAIADAEQ-RGELAL-KDAQAKV----AELEAALRNAKQDMARQLR
EYQELMNVKLALDVEIATYRKLLEGEES---------------------------RLE-S
---GM---Q--------NMSIHTKTTSG--------------------------------
---------------YSGGLSPA-------------YGNLTSP-----------------
-----------------------------------------GLNYGVS--------FQ--
---------------------------------S--------NFGSGG---------SSG
SFSRT-------------------SSTKTVVVKKI------ETRDGKLVSESSDVLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
MA--STSTTIR--SH-SSSRRGFSAGSARLPG-----VSRS-GFSSVS-VSRSRGSGGLG
G-------------------------------AC-----------GGAGFGSRSLYGLGG
S-KRISIGGG----SC--GYGGA-------------SGV--GS----G--LGLGG---G-
--------------SSYSYG--SGLGV------GG-----------------GF----SS
S--SG-RALGG-GLSGPQTPYLKSI-VN--PPRSI------HRGSVNSTMLTPL----NL
QIDPAIQR--VRAEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVRQNL--EPLFE-QYINNLRRQLDSIVG
ERGRLDSELRG-MQDLVEDFKNK-YEDEINKRTA---AENEFVTLK--K---DVDAAYMN
KVELQAKADTLTDEINFLRALYEA-----ELSQMQTHISDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEEIAQ-RSRAEAESWYQSK--YEELQVTAGRHGDDLRNTKQEIAEIN--
RMIQRLRSE-I--DHVKK------------------------------------------
-----Q-CA--NLQAAIADAEQ-RGEMAL-KDAKNKL----EGLEDALQKAKQDLARLLK
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLN-G
EG--VG-QV-------N-ISVVQSTV----------------------------------
------------SSGYGCASG-------------------------V-------------
---------------------------------------GSGLGLGGGSS----YS----
-----------------------YGSG--------------LGVG--------------G
GFSSS---SGRAIG--GGLS--SVGGG-SSTIKYT----TTSS-----------------
------------------------------------------------------------
------------SSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
----------------------------------------------------------MR
-SSVSRQTYST--------KGGFSSNSASGG---GGSRGHT-SFSSVT-VSRSSSSGGG-
--------------------------T--------------RCGPSRAGFGSRSLYNLGG
S-KSISVSVAGGASSG-RAL----------------------------------------
--------------GGFGFG------------------SGAYV-----------------
-------GLG-------AGRQAFGP-AC--PPGGI------QEVTVNQSLLTPL----NV
EIDPEIQR--VRTQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQGQNSG--VTRNNL--EPLFE-NYLGNLRRQLDNLQS
DRGRLDSELRN-VQDVLEDFKSK-YEDEINKRTA---AENEFVLLK--K---DVDAAYMS
RMDLTGKVGTLTEELDFLNHLYEM-----ELSQVQTHVSDT----NVILSMDNNRRLDLD
SIIA-EVKAQYELIAQ-RSRAEAEAWYQTK--YEELQVTAGKHGDSLRDTKNEIAELT--
RTVQRLQGE-V--DAVKK------------------------------------------
-----Q-CQ--QLQAAIAEAEQ-RGDMAL-KDAQKKL----GDLDMALHQAKEDLARLLR
DYQALMNVKLALDVEIATYRKLLESEE--------------------------S-RMS-G
ECPSA---V--------SISVTGNSTTVCG------------------------------
-----------------GG--------------AASFGGGMSLGGG---GG--ASKGGFS
----------------------------------------------T----------V--
KGGAVSG--GTSILRKT--TTVKTSSRRY-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQASKT--S--GGGSQGFSGGSAVVSS------SSR-M-SC---VTRSGVA-G--
-----GG-------------------------AYGFR----SG---AGGFGSRSLYNLGG
N-KSISISVAAGGP-RAGGFGGGRS------SCG--FAGGYGGGFGGGYGGGFGGGFGGV
RG----MGGGFGGAGGFG--------------GA-----GGFGGASG------------F
GGPGGFG--------S---PGGFGP-GG--FPGGI------QEVTINQSLLQPL----NV
EIDPQIGQ--VKA QEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQQQSTSSI--SGTNNL--EPLFE-NHINYLRSYLDNILG
ERGRLDSEMRN-MQDLVEDFKKK-YEDEINKRTA---AENEFVTLK--K---DVDGAYMN
KVELQAKVDALIDEINFLRTLYDA-----ELSQMQSHISDT----SVVLSMDNNRSLDLD
SIIA-EVRAQYEDIAQ-RSKAEAEALYQTK--LGELQTTAGRHGDDLRNTKSEIIELN--
RMIQRLRAE-I--ESIKK------------------------------------------
-----Q-NA--NLQTAIVEAEQ-RGEMAL-KDANAKL----QELQAALQQAKDDLARLLR
DYQELMNVKLALDVEIATYRKLLEGEE--------------------------YS-----
------------------------SST---------------------------------
--------TSASAGGYAGG-YGGG------------VGGGLGG-----------------
--------------------GL----GAGG---------GSSSGFGRGGG-G-GIGGG--
IGGGIGGGIGGGF-----------------------------GGGSSGGF--SGGSGF--
GSSSG--AR-YGVSGGGFSS----ASNRGGSIKFS----QSS------------------
------------------------------------------------------------
----------QSS-QRYSR-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--M-SRQSSIT--FQSG-SRRGFSTTSATTPA-----AGRS-RFSSVS-VARSAV--GSG
GLGRIS--------------------------SA------------GASFGSRSLYNLGG
A-KRVSISGC-GSS-----FRSG-------------FGG--RA----SQGFGV-----N-
--------------SGFGYG--GGVGGGF-------------------------------
--------------SGPSFP------VC--PAGGI------QEVTVNQSLLTPL----NL
QIDPTIQR--VRA EEREQIKTLNNKFAAF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQGSR----TVRQNL--EPLFD-SYISEFRRQLESVTT
ERGRLEAELRN-MQDVVEDFKIR-YEDEINKRTA---AENEFVALK--K---DVDAAYMN
KVELEAKVKSLPEEINFLHSVFDA-----ELSQLQTQVSDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEDIAN-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEISEMN--
RMIQRLRAE-I--DSVKK------------------------------------------
-----Q-CS--SLQTAIADAEQ-RGELAL-KDARAKL----VDLEEALQKAKQDMARLLR
EYQELMNIKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VS-PVNIS--------VVTSTL----------------------------------
------------SSGYGSGS--SIG-----------------------------------
---------------------------------------GGSLGLGGGSG----YSFTT-
-----------------------SG-------GHSLG--A--GLGG-------------S
GFSAT---GNRGLGG------------SGSSVKFV----STTS-----------------
------------------------------------------------------------
------------SSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
--------------------------------------------------------MSSV
R--VTQKTYK--VS---SGPRAFSSRSYTSAPG-----TRI-SSSAF-------------
-------------------------------------------------------SRVGG
S---------------------SS-----------SFRGT------------LGG-----
---------------GFS------------------------------------------
-----------------GAGG----------VGGI------TAVTVNQNLLSPL----KF
EVDHNMQA--VRTQEKEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQQ-QKT-----SRSNM--DNMFE-SYINNLRRQLEMLGQ
EKLKLEAELGS-MQGLVEDFKNK-YEDEINKRTE---MENEFVLIK--K---DVDEAYMN
KVELESRLEGLTDEINFLRQLHEE-----ELRELXXXXXXX----XXXXXXXXXXXXXXX
XXXX-XXXXXXXXXXX-XXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXXXXXXXX--
XXXXXXXXX-X--XXXXX------------------------------------------
-----X-RA--SLEAAIADAEQ-RGELAI-KDAQNKL----AELEAALLRAKQDMTQQLR
EYQELMNVKLGLDIEIATYRKLLEGEES---------------------------RLE-S
---GM---Q--------NMSIHTKTTSG--------------------------------
---------------YSG---------------------GLTS-----------------
---SYG------------------------------GLTSPGLTYGLS--------SL--
--------------------------------QS--------SLSPGG---------GSS
SFSRS-------------------SSTKAVVVKKI------ETRDGKLVSESSDVLSK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
-----------------------------------------------------------M
KASMSRQTYST--------KGGFSSCSASGSRGMDGARTHT-SFSSVT-MSRGGSRLGG-
--------------------------A--------------ACGGPKTSFSSHSLYNLGA
N-RSISGSVVQRASQG-RSF----------------------------------------
-----------------G-G------------------AGSFL-----------------
-------GLG-------TMRSNFGA-SC--PAGGI------QEVTVNQSLLTPL----NV
EIDPEIQR--VRIQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQGQNTK--SP-ENL--EPLLE-SHINKLMRYLDMLNN
EKEKMKTELSN-VQDQVDNFKDR-FEEEIHKRTE---AENEYVVLK--K---EVDHDYSV
RENLKANVFILRENMDFLMNFFDA-----EREGTQTQVSDT----NVVLSMDNNRSLDLD
SIIA-EVKSQYEEIAR-RSRAEAESWYQTK--YEELQVTAGKHGDHLRDTKNEIAELT--
RVVQRLQGE-I--DSVKK------------------------------------------
-----Q-CQ--QLETAIADSEQ-RGEMAV-KDAQKKL----GDLEKALHHSKEELTKLLR
DYQELMNIKLALDLEIATYKKLLESEE--------------------------S-RMS-G
ECPNA---I--------SISVTGSSTTMCG------------------------------
-----------------GGSQVI---------GSGSFGGGLSMGNS---GG--GVKG---
SY----------------------------------------GSY------------V--
KAGPSTG--GTSILKKVTSTTVKSSSRRY-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MIARQQCVR-----G-GPRGFSCGSAIVGSG----KRG--AFSSVS---VSGGA----
-----------------------------------------GRCS-SGGFGSRSLYNLGG
N-KSISLSVAGSRQ-GA-CFGGAGG-----------FGT---------------------
---------------------------------------GGFG-----------------
---GGFGG----SFS--GKGGPGFP-VC--PAGGI------QEVTINQSLLTPL----HV
EIDPEIQK--VRT EEREQIKLLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWKLLQQQTTST----SSKNL--EPLFE-TYLSVLRKQLDTLVN
DKGRLQSELKT-MQDSVEDFKTK-YEEEINKRTA---AENDFVVLK--K---DVDAAYMN
KVELEAKVDSLNDEINFLKVLYDA-----ELSQMQTHVSDM----SVVLSMDNNRNLDLD
SIIA-EVRAQYEEIAQ-RSKAEAEALYQTK--VQQLQISVDQHGDNLKNTKSEIAELN--
RMIQRLRAE-I--ENIKK------------------------------------------
-----Q-CQ--TLQASVADAEQ-RGENAL-KDAHSKR----IELETALQQAKEELARMLR
EYQELMSVKLALDIEIATYRKLLEGEE--------------------------C-RMS-G
ECQSA---V--------SISVVGGSTSTGG------------------------------
---------------ISG-G---LGS-----------------------------GS---
---GFGL------------------------SSGFGSG--SGSGFGF--G-GS-------
----VSGSSSSKIISTTTLNKRR-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--------------MKRTSVRSFSSRSYTPGPV-----VGG-S-----------------
--------------------------------------------------------RIST
S------------------YASSS-----------YGGSR------------LGSGV---
--------------SFRGAS----------------------------------------
---------------ASL-GGGG-------GGGGI------TAVSVNRSLLAPL----NL
EIDPAIQQ--VRTREKEEIKSLNNKFAGF------IDK--VR------------------
----FLEQQNK-MLDTKWSLLQN-QKI-----TRSNM--DSMFE-AYINNLRRQLDGLGQ
ERVRLDSELGN-MQGLVEEFKSK-YEDEINHRTE---KENDFVLLK--K---DVDEAYMN
KIELESRLESLTDELNFLRQLHEE-----ELRVLQSQISDT----SVVLSMDNNRSLDLD
GIIA-EVKAQYEEVAA-RSRAEAESTYKSK--YEELQSVAGKHGDDLRITKNEISELN--
RLITRIQSE-I--DGLKG------------------------------------------
-----Q-RA--NLESAIAEAEE-RGELAV-KDATAKL----SELEAALQRAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEES---------------------------RLE-S
---GM---Q--------NLSIQTKT-----------------------------------
-----------------TG-----------------YSGALSS-----------------
---GYG------------------------------G-YGSGYGGGFSSYSSGGYSMN--
--------------------------------S------------------------SPL
ESSVV-------------------SKSKAIVIKKI------ETRDGKLVSESSDVLSN--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--------------------------------R----GAQV-RLSSA----RPGG-----
----------------------------------------------FSG---SSLYGLG-
------------SS-RPRVAM--RS-----------------------------------
---------------AYG------------------------------------------
----------------V-------P-----VGAGI------REVTINQSLLVPL----RL
DTDTSLQR--VLQ EEREQIKTLN-KFASF------IDK--VP------------------
----FLEQQNK-LLETKWALLQEQKSA-----KSSHL--PDIFE-AQIAGLRGQLEVLQV
DGGCLEVELRS-MQDVVEDFKNK-YADEINCRTA---AESKFVVLK--K---DVDAAYMS
KVELEAKVVALNDEINFLRTLHEM-----ELTELQSQISDR----SVVLSMDNSLSLDLD
SIIA-EVKAQYEEMAK-CSRAEAEAWYQTK--FETLQAQAGKHGDNLWNTRKESAEMN--
RAIQRLQAE-I--DAMKN------------------------------------------
-----Q-RA--KLEATIAEAEE-HGELAF-KDARAKQ----EELEAALQRAKQDMARQLR
EYQELMSVKLALEIKIATYCKLLEGQE--------------------------S-RLA-G
DGVGA---V--------NISV---------------------------------------
----VNST-GGSGSG-SGSG----------------GGIGLSFGG-----TMGSNALSFS
SS-----AGPGP------------------------------------------------
--------LKAYSIRTASTTNIMPLHNRKILSQKQIKKNKDYNKKWSLDYLEIL-A----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
----------------------------------------------------------MR
-SSVSRQTYST--------KGGFSSNSASGG---SGSQART-SFSSVT-VSRSSGSGGG-
--------------------------A--------------HCGPGTGGFGSRSLYNLGG
H-KSISVSVAGGALLG-RAL----------------------------------------
--------------GGFGFG------------------SRAFM-----------------
-------GQG-------AGRQTFGP-AC--PPGGI------QEVTVNQSLLTPL----HV
EIDPEIQR--VRT QEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQGQNLG--VTRNNL--EPLFE-AYLGSMRSTLDRLQS
ERGRLDSELRN-VQDLVEDFKNK-YEDEINKHTA---AENEFVVLK--K---DVDAAYMG
RMDLHGKVGTLTQEIDFLQQLYEM-----ELSQVQTHVSNT----NVVLSMDNNRNLDLD
SIIA-EVKAQYELIAQ-RSRAEAEAWYQTK--YEELQVTAGKHGDNLRDTKNEIAELT--
RTIQRLQGE-A--DAAKK------------------------------------------
-----Q-CQ--QLQTAIAEAEQ-RGELAL-KDAQKKL----GDLDVALHQAKEDLTRLLR
DYQELMNVKLALDVEIATYRKLLESEE--------------------------S-RMS-G
ECPSA---V--------SISVTGNSTTVCG------------------------------
-----------------GG--------------AASFGGGISLGGS---GG--ATKGGFS
TN----------------------------------------VGYST----------V--
KGGPVSA--GTSILRKT--TTVKTSSQRY-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R-V-TQKSYK--VST--SGPRAFSSRSFTSGPG-----ARI-SSSSL-------------
-------------------------------------------------------SRVGS
S----------------------S-----------SFRGS------------LGTGM---
--------------GL---G----------------------------------------
---------------GF--G-GA-------GVGGI------TAVTVNQSLLSPL----KL
EVDPNIQA--VRTQEKEQIKSLNNKFASF------IDK--VRALSSRLTVLRSFFLLPSQ
RC VRFLEQQNK-MLETKWSLLQQ-QKT-----SRSNM--DNMFE-SYINNLRRQLEALGQ
EKLKLEAELGN-MQGLVEDFKNK-YEDEINKRTE---MENEFVLIK--K---DVDEAYMN
KVELESRLEGLTDEINFLRQIHEE-----EIRELQSQISDT----SVVLSMDNSRSLDMD
GIIA-EVRAQYEEIAN-RSRAEAETMYQIK--YEELQTLAGKHGDDLRRTKTEISEMN--
RNINRLQAE-I--EALKG------------------------------------------
-----Q-RA--TLEAAIADAEQ-RGEMAI-KDAQTKV----TELETALQRAKQDMARQLR
EYQELMNVKLALDIEITTYRKLLEGEES---------------------------RLE-S
---GM---Q--------NMSIHTKTTSG--------------------------------
---------------YSG---------------------GLSS-----------------
---SYG------------------------------GLTSPGFNYGMN--------FQ--
---------------------------------P--------GFGSVR---------GSN
TF--T-------------------TTTKAVVVKKI------ETRDGKLVSESSDVVSK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--TMSSKSTIR--SQ-SVSHRGFSASSARVPG-----VCRS-GFSSVS-VSRSRGSGGLG
G-------------------------------VY-----------GGAGFGSRSLYGLGG
S-KRISIGGG----SC--AIGGG-------------YGG--RV----GGGFGYGGGV-A-
--------------SGFGFG--GA--A------GG-----------------GF----GL
G--GG-AGFAG-GYGGPGFP------VC--PPGGI------QEVTVNQNLLTPL----NL
QIDPTIQR--VRTEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVRQNL--EPLFE-QYINNLRRQLDSILG
ERGRLDSELRN-MQDTVEDFKNK-YEDEINKRTA---AENEFVTLK--K---DVDAAYMN
KVELQAKVDALTDEINFTRALYDA-----ELAQMQTHVSDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEEIAQ-RSRAEAESWYQSK--YEELQVTAGRHGDDLRNTKQEIAEIN--
RMIQRLRSE-I--DHVKK------------------------------------------
-----Q-CA--NLQSAIADAEQ-RGELAL-KDAKNKL----AGLEDALQKAKQDMARLLK
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VG-QV-------N-ISVVQSTV----------------------------------
------------SGGYGSAGGY-----------------GS--ASGM-------------
---------------------------------------GGGSGLGGGSG----YS----
-----------------------YGSG-----H-SLG--G--------------------
GFSSS---SGRGVG--GGFS--SSGGS-SSTIKYT----TTS--S---------------
------------------------------------------------------------
------------SSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSR
QFT-----CK----SGAATKGGFSGCSAVLSGGS------------SP-SFRAG------
------------------------------------------GKGLSGGFGSRSLYSLGG
S-RGISFNMASGSG-KSGGY----------------------------------------
-------------------------------GFGRGRA----------------------
------SGFAGSMFGSVVLGPVCPT-VC--PPGGI------HQVTVNESLLAPL----NV
ELDPEIQK--VRAQEREQIKVLNNKFASF------IDK--VR------------------
----FLEQQNQ-VLETKWELLQQLDLNN----CKNNL--EPILE-GYISNLRKQLETLSG
DRVRLDSELRN-VRDVVEDYKKR-YEEEINRRTA---AENEFVLLK--K---DVDAAYAN
KVELQAKVDSMDQEIKFFKCLFEA-----EITQIQSHISDM----SVILSMDNNRDLNLD
SIID-EVRAQYEEIAH-KSKAEAEALYQTK--FQELQLAAGRHGDDLKNTKNEISELT--
RLIQRIRSE-I--ENVKK------------------------------------------
-----Q-AS--NLETAIADAEQ-RGDNAL-KDARAKL----DELEAALHQGKEELARMLR
EYQELMSLKLALDMEIATYRKLLESEE--------------------------C-RMS-G
EYPS-P--V--------SISIISSTSGSSG------------------------------
------------YGFRPSSVSGG-YV----ASSGSC-----ISGVCSVRGGDARSRG---
ST--------------------SDYKDTLGKG----------SSLSA-------------
------------------------------------------------------------
----------------------------------P----SKK------------------
------------------------------------------------------------
----------ASR-----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
H-------------L---SSQVFSSRSAAFPGR----GAQV-RLSSV----RPGG-----
----------------------------------------------G-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------EREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-LLETKWTLLQEQRSA-----KSSGL--PSIFE-AHIAGLRRQLEGLQL
EGGRLEVELRN-VQDAVEDFKNK-YEDEINRRTA---AENEFVVLK--K---DVDTAYMN
KVELEAKLDALNDEINFFKTLYET-----ELAELQSQISDT----SVVLSMDNSRSLDLD
GIIA-EVKAQYEEITS-RSRAEAEAWYQTK--FETLQAQAGKHRDDLRNTRNEIAEMS--
RAIQRLQAE-I--DSIKN------------------------------------------
-----Q-CA--KLEAAIAEAEE-HGELAL-KDARAKK----EELEAALHRAKQDMARQLR
EYQELMNVKIALDIEIATYRKLLEGEE--------------------------S-RLA-G
DGVGA---V--------NISV---------------------------------------
----VNST-GGG------GS----------------GLAGLAFRG-----TMGSNALSFS
SG-----GGPGA------------------------------------------------
--------IKSYSTRTSATTHRSVRK----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQSSVS--FR-SGGSRSFSAASAITPS-----VSRT-SFSSV---SRSGG----G
GGGRVS--------------------------LG-------GA-CGVGGYGSRSLYNLGG
T-KRISISAS----RG--NFRDR-------------FGASAGS----G--FGFGGGV-G-
--------------SGLGYG--GGAG-G------------------------GF----GL
G--GGAGFG-G-GYGGAAFP------VC--PPGGI------QEVTINQSLLTPL----NL
QIDPTIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWALLQEQGTR----TVKQSL--DPLFE-QYINNLRRQLDSILG
ERGRLDSELRN-MQDLVEDFKNK-YEDEINKRTT---AENEFVMLK--K---DVDAAYMN
KVELEAKVDALMDEINFMKMFFDA-----ELSQMQTHVSDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEDIAN-RSRTEAESWYQTK--YEELQQTAGRHGDDLRNTKHEISEMN--
RMIQRLRAE-I--DNVKK------------------------------------------
-----Q-CA--NLQAAIADAEQ-RGELAL-KDARNKL----AELEEALQKAKQDMARLLR
EYQELMNTKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VG-PV-------N-ISVVTNSM----------------------------------
------------STGYGGGS---------------GFGG--GLSGGFGGG----L-----
-----G----------------------------------------GGSS----SSYYS-
-----------------------SSSG-----GVGLS--GGLSAGG-------------S
GFSAS---SGRGMGASFGS----GGG-SGSSVKFV----STTS-S---------------
------------------------------------------------------------
-------------SRRTFKS----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
----MQNLVT--QKS--SGPWAFSSCTYMSGPG-----VCI-SSLSC-------------
-------------------------------------------------------SRVGS
S----------------------------------SFRGG------------LGGGY---
--------------G---------------------------------------------
------------------GASG---------MGGI------IAIMVNQSLLSPL----NL
EVDPNIQA--VCT QEKEQIKTLNNKFASF------IDK--VW------------------
----FLEQQNK-VLETKWSLLQQ-QKM-----ARSNM--DNMLE-SYINNLRRQLETLGQ
EKLKLEAELGN-MQGLGEDFKNK-YEDEINKHTE---MENEFVLIK--K---DVDEAYMN
KVELESLLEGLTDEINFLRQLYEE-----EIRELQSQISDM----SMVLSMDYSCSLDMD
SIIP-EVKVQYEEIAN-CSRAEAESMYQIK--YEELQTLAGKHGDDLRRTKTEISEMN--
RNISWLQAE-T--EGLKG------------------------------------------
-----Q-RA--SLEAAITDAKQ-RGELAV-KDANAKL----SELEAALQRAKQDMMGQLR
EYQELMNVGLTLDIEIATYRKLLEGEES---------------------------RLE-S
------------------------------------------------------------
----------------------------------------VIS-----------------
---AYG------------------------------GLTSPGIIYRLG------------
---------------------------------S--------SFGSGA---------DSS
SFSCT-------------------SSTRAVVVKKI------ETHDGKLESESSDVLSK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--M-SRQSTIT--FQTG-SRRGFSTASATSPA-----TGRS-RFSSVS-VTHSPG--GSG
GLGRIS------------------------------------------GFGSRSLYNLGG
T-KWVSISGC-GSN-----FRSG-------------FGG--RA----SSGFGV-----S-
--------------SGFGYG--GGIGVGH-------------------------------
--------------AGWGFS------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPNIQR--VRK EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWSLLQEQGTK----TVRQSL--EPFFE-AYITDLRRQLDSITT
ERGRLDAELRT-MQDVVEDFKVR-YEDEINKRTA---AENEFVALK--K---DVDAAYLN
KVDLEAKANSLTDEINFLQMLFEA-----ELCQMQTRVSDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEEIAN-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEISETN--
RMIQRLRAE-I--DNIKK------------------------------------------
-----Q-CA--SLQTAIADAEQ-RGELAL-KDARAKL----VDLEEALQKSKQDMARLLR
EYQELMNIKLALDVEIATYRKLLEGEE--------------------------S------
--------------------VVTSTI----------------------------------
------------SSGYGGGS--SIG-----------------------------------
---------------------------------------SGSLGLGGGSG----HS-ST-
-----------------------SG-------GHSL--------GG-------------S
SFSNS---SSRGLGG------------SGSSIKFV----STMS-----------------
------------------------------------------------------------
------------SSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--M-SRQSTIT--WHSG-GRRAFSTTSASTPV-----AGRP-RFSSIS-VARPAG--SSG
GPGRMG--------------------------GA------------GAAFGSRSLYNLGG
T-KRLSIGGCSGGG-----FRGG-------------FGG--RA----SGGYGV-----S-
--------------SAFSHA--GGIGGSH-------------------------------
--------------GGPGFP------AC--PSGGI------QEVTVNQSLLTPL----NL
QIDPTIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQEQGSR----TVRQSL--EPFFD-TYVNDLRRQLDGITA
ERGRLDAELRN-MQEVVEDFKAR-YEEEINKRAA---AENEFVALK--K---DVDGAYMN
KVELEAKVDSMTDQISFHRMIFEA-----ELSQMQNQVSDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEDIAN-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEISEMN--
RMIQRLRSE-I--DNVKK------------------------------------------
-----Q-CT--SLQTAIADAEQ-RGELAL-KDARAKL----VDLEEALQKAKQDMARLLR
EYQELMNVKLALDMEIATYRKLLEGEE--------------------------C-RLS-G
EG--VA-PVNIS--------VVTSTV----------------------------------
------------SSGYGGGS--SIG-----------------------------------
---------------------------------------GGSLGLGGGSS----YSFTT-
-----------------------SG-------GHSLG--T--GLGG-------------S
GFTTS---SSRGPGG------------SGSSVKFL----STTS-----------------
------------------------------------------------------------
------------CSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
MA--STSTTIR--SH-SSSRRGFSAGSARLPG-----VSRS-GFSSVS-VSRSRGSGGLG
G-------------------------------AC-----------GGAGFGSRSLYGLGG
S-KRISIGGG----SC--AIGGG-------------YGS--RA----GGSYGFGG-A-G-
--------------SGFGFG--GG--A------GI-----------------GF----GL
G--GG-AGLAG-GFGGPGFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPTIQR--VRA EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWTLLQEQGTK----TVRQNL--EPLFE-QYINNLRRQLDSIVG
ERGRLDSELRG-MQDLVEDFKNK-YEDEINKRTA---AENEFVTLK--K---DVDAAYMN
KVELQAKADTLTDEINFLRALYEA-----ELSQMQTHISDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEEIAQ-RSRAEAESWYQSK--YEELQVTAGRHGDDLRNTKQEIAEIN--
RMIQRLRSE-I--DHVKK------------------------------------------
-----Q-CA--SLQAAIADAEQ-RGEMAL-KDAKNKL----EGLEDALQKAKQDLARLLK
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLN-G
EG--VG-QV-------N-ISVVQSTV----------------------------------
------------SSGYGGASG-------------------------V-------------
---------------------------------------GSGLGLGGGSS----YS----
-----------------------YGSG--------------LGVG--------------G
GFSSS---SGRAIG--GGLS--SVGGG-SSTIKYT----TTSS-----------------
------------------------------------------------------------
------------SSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MNRQVCRT--TVSSGGGKGFSGRSAVVSG------SSR-MSSC---MARSGG--G--
-----GG-------------------------ACGSR----SG--GAGGFGSRSLYSLGG
S-KSISISVGA-------------------------------------------------
-----------------------------------------------------------F
GGPGGFGGPG--GFGG---PGGFGP-GG--FPGGI------QEVTVNQSLLQPL----NV
EIDPQIGA--VKSQEREQIKTLNNKFATF------IDK--VR------------------
----FLEQQNK-VLETKWELLQQHGTGSI--SGTNNL--EPLFE-TYISSLHRHLDGLLS
ERSRLDGELRS-MQELVEDFKRK-YEEEINKRTT---AENEFVTLK--K---DVDAAYMN
KVELQSRVTSLTDEINFLRALYEM-----ELSQMQSHVSDT----SVVLSMDNNRFLNLD
SIIA-EVKAQYEEIAQ-RSKAEAEALYQTK--LGELQSTAGRHGDDLKSTKSEIMELN--
RMIQRLRAE-I--ESVKK------------------------------------------
-----Q-NA--NLQTAIADAEQ-RGELAL-KDARVKL----EELQAALQQAKEDLARLMK
DYQELMNVKLALDVEIATYRKLLEGEY--------------------------YSPMS-G
EHQNA---V--------SIWPLAINHPAYS---------------VWGG---------PW
DPQMA----EKAEGGEEGRNGC-PG------S--AGLGQ---------------------
------------------------------------------------GP--VGWGVM--
IGGGRRGGLGAGILQ------------------------------------------TDP
PLSSG--SR-CGLG-GGFSSGSSRGGVSGSSVRFS----QSS------------------
------------------------------------------------------------
-----------SS-QRCPR-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
MS--STSTTIR--SH-SSSRRGFSAGSARLPG-----VSRS-GFSSVS-VSRSRGSGGLG
G-------------------------------AC-----------GGAGFGSRSLYSLGG
S-KRISIGGG----SC--AISGG-------------YGS--RA----GGSYGFGG-A-G-
--------------SGFGFG--GG--A------GI-----------------GF----GL
G--GG-AGLAG-GFGGPGFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPTIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWTLLQEQGPK----SVRQSL--EPLFE-QYINNLRRQLDSIVG
ERGRLDSELRG-MQDLVEDFKNK-YEDEINKRTA---AENDFVTLK--K---DVDAAYMN
KVELQAKADTLTDEINFLRALYEA-----ELSQMQTHVSDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEEIAQ-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEISEIN--
RMIQRLRSE-I--DHVKK------------------------------------------
-----Q-CA--NLQAAIADAEQ-RGEMAL-KDAKNKL----EGLEDALQKAKQDLARLLK
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLN-G
EG--VG-QV-------N-ISVTQSTV----------------------------------
------------SSGYGGASG-------------------------V-------------
---------------------------------------GGGLGLGGGSS----YS----
-----------------------YGSG--------------LGVG--------------G
GFSSS---SGRVIG--GGLS--SVGGG-SSTIKYT----TSSS-----------------
------------------------------------------------------------
------------SSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
MA--STSTTIR--SH-SSSRRGFSAGSARLPG-----VSRS-GFSSVS-VSRSRGSGGLG
G-------------------------------AC-----------GGAGFGSRSLYGLGG
S-KRISIGGG----SC--AIGGG-------------YGS--RA----GGSYGFGG-A-G-
--------------SGFGFG--GG--A------GI-----------------GF----GL
G--GG-AGLAG-GFGGPGFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPAIQR--VRA EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVRQNL--EPLFE-QYINNLRRQLDSIVG
ERGRLDSELRN-MQDLVEDLKNK-YEDEINKRTA---AENEFVTLK--K---DVDAAYMN
KVELQAKADTLTDEINFLRALYEA-----ELSQMQTHISDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEEIAQ-RSRAEAESWYQSK--YEELQVTAGRHGDDLRNTKQEIAEIN--
RMIQRLRSE-I--DHVKK------------------------------------------
-----Q-CA--NLQAAIADAEQ-RGEMAL-KDAKNKL----EGLEDALQKAKQDLARLLK
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLN-G
EG--VG-QV-------N-ISVVQSTV----------------------------------
------------SSGYGSASG-------------------------V-------------
---------------------------------------GSGLGLGGGSS----YS----
-----------------------YGSG--------------LGVG--------------G
GFSSS---SGRAIG--GGLS--SVGGG-SSTIKYT----TTSS-----------------
------------------------------------------------------------
------------SSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQSSVS--LR-TGGSRSFSAASAITPS-----VSRT-SFTTV---SRSGG--GGG
GFGRVS--------------------------LG-------GACGV-GGYGSRSLYNLGG
S-KRISISAS----GG--GFRNR-------------FGAG--A----GGGYGFGGGA-S-
--------------SGFGFG--GGAGGGF-G-LGG-----------------GA----GF
G--GGA-GFGG-GFGGPGFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPTIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVRQNL--EPLFE-QYINNLRRQLDSILG
ERGRLDSELRN-MQDLVEDFKNK-YEDEINKRTT---AENEFVMLK--K---DVDAAYMN
KVELEAKVDALMDEINFTKMFFEA-----ELSQMQTHVSDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEDIAN-RSRTEAESWYQTK--YEELQQTAGRHGDDLRNTKHEISEMN--
RMIQRLRAE-I--DNVKK------------------------------------------
-----Q-CA--NLQNAIADAEQ-RGELAL-KDARNKL----AELEDALQKAKQDMARLLR
EYQELMNTKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VG-PV-------N-ISVVTNTL----------------------------------
------------SSGYGGGS-G--------------FGG--GLGGGLGGG----L-----
-----GGGLGGGL--------------------------GGGIG-GGGGS----SYYSS-
-----------------------SSSG-----GVGLG--GGLSVGG-------------A
GFSSS---SGRSL--GFGS---GG-G-SSSSVKFV----STTS-S---------------
------------------------------------------------------------
-------------SRKSFKS----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------MQSQYF
ITLLAIKNTVR--CQS-SSRRGFTANSARVPG-----LSRS-GFSSVS-VCRSRGSGGIG
A-------------------------------VC-----------GGAGFGSRSLYGLGG
S-KRISIGGG----SC--AAGGV-------------YGS--RV----GGG------V-G-
--------------SGLGYG--GG--L------GG-----------------GF----GL
G--GG-AGFGG-GYGGAGFP------VC--PPGGI------QEVTINQSLLTPL----NL
EIDPTIY R--LRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWALLQEQGTK----TVRQNL--EPLFE-QYISNLRRQLDSIQG
ERGRLDSELRN-MQDTVEDYKSK-YEDEINKRTA---AENEFVTLK--K---DVDAAYMN
KTELQAKVDSLVDEINFLRAFYDA-----ELSQMQTHISDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEDIAQ-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEIAEIN--
RMIQRLRSE-I--DHVKK------------------------------------------
-----Q-CT--NLQAAIADAEQ-RGELAL-KDARNKL----EGLEDALQKAKQDMARLLK
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLN-G
EG--VG-QV-------N-ISVVQSTV----------------------------------
------------SSGYGGV-------------------------GGM-------------
---------------------------------------GSAGGLGAG-S----GYSY--
------------------------SSG--------------HSLG--------------G
GFSSG---SGRGISIGGGLS--SVGG-STSSIKYT----TS-S-----------------
------------------------------------------------------------
------------SSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------M--
----ASQVCKK--SL-SSGSRSFSGCSAVVPGRSS-SSSTR-M-SC---VARSAAA-G--
-----SG-------------------------ASGIR----GV---AGGFGSRSLYNLGG
H-KSISMSVAAGGS-RAGGFGGGRS------ICGSGFGGGYGGGFGGGS-----------
-----GMGGDFGGAGAF-------------------------------------------
------GGAG--GFGS---P-----------CRGI------QEVTVNQSLLQPL----NV
EIDLQIGQ--VRAQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQQQTTSSG--ASPSNL--EPLFE-SYISFLRQQLDSLLG
EKGGREGELRS-VQGMLEDFKKK-YEDEINKRTT---AENEFVALK--K---DVDTAHAS
TAELQAKAHSLTDEIGFLRTLFDM-----ELSQMQSHVSDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEEIAQ-RSKAEAEALYQTK--LGELQTTAGRNGDDLKSTKSEITELN--
RLIQRLRAE-I--ESIKK------------------------------------------
-----Q-NA--SLQSAITDAEQ-RGELAL-QDANAKL----AELQAALQKAKDDLARLLR
DYQELMTVKLALDVEIATYCKLLEGEE--------------------------S-RMS-G
ECQDA---V--------SISVVNHVTS---------------------------------
--------VSSGSGGSRGGFRGAGDS----SS--GGYRGGSGSGS---------S-----
--------------SSS-SGYR----GVNS---------NSSGGYGGSSS--T-------
--------------TTNSSGYRGVSGGGSSSGRR------DSSEGYLSGS--YSESQSGR
GSGSG--SV-QTSGGSGYRP----AGESSTSIRFS----QTS------------------
------------------------------------------------------------
----------SSR-QQCSK-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
----------------GGYGGGVGAGFGF---------GGG------A-RSGF-G-----
------------------------------------------FGAGSGG------FGLGG
G-AGFVGGYG--------------------------------------------------
------------------------------------------------------------
-------------GSG--FP------VC--PPGGI------QEVTINQNLLTPL----NL
QIDPTIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGIK----TVRQNL--EPLFE-QYINDLRRQLDSILG
ERGRLDSELRS-MQDLVVDFKNK-YEDEINKRTA---AENEFVNLK--K---DVDTAYMN
KVELQAKVDSLTDEINFLRAFYDA-----ELAQMQTHISDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEDIAQ-RSRAEAESWYQSK--YEELRVTAGRHGDDLRNTKQEISEIN--
RMIQRLRSE-I--D----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQSSVS--FR-SGGSRSFSAASAITPS-----VSRT-SFSSV---SRSGGG--G-
-GGRVS--------------------------FG-------GA-YGAGGYGSRSLYNVGG
S-KRISFSSG----GG--SFRNR-------------FGAG--A----GGSFGFGGGA-G-
--------------SGFGFG--GGAG-S------------------------GF----GF
G--GGAGFG-G-GYGGAGFP------VC--PPGGI------QEVTINQNLLTPL----NL
QIDPTIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWALLQEQGTK----TVRQNL--EPLFE-QYINNLRRQLDGVLG
ERGRLDSELRN-MQDLVEDFKNK-YEDEINKRTT---AENEFVMLK--K---DVDAAYMN
KVELEAKVDALMDEINFMKMFFDA-----ELSQMQTHVSDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEDIAN-RSRTEAESWYQTK--YEELQQTAGRHGDDLRNTKHEISEMN--
RMIQRLRSE-I--DNVKK------------------------------------------
-----Q-CA--NLQNAIADAEQ-RGELAL-KDARNKL----TELEEALQKAKQDMARLLR
EYQELMNTKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VG-PV-------N-ISVVTNSV----------------------------------
------------SSGYGGSS-LGFGG----G---TG------FAGGLGSG----L-----
-----G----------------------------------------GG-G----GGYYS-
-----------------------SSSG-----GGGLG--GGLSVGG-------------S
GFSAS---SGRGM--GFGS----GGG-SSSSVKFV----STTS-S---------------
------------------------------------------------------------
-------------SRRSFKS----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
-------------------------------MA------QRSV---SIKSSGGGRSF---
-------------------SASSASLLPGCRTS----FSSV-SVSQG----G--------
---------------------------------------KS-GSRLGGGFGTRSLHNLVG
G-KRISVSGAYRSG-R-AGYGG-AC-----------------------------------
---------------GLGYG-------GIGYRA---------------------------
--------------GGYGFGGGMMA-----GSGGI------HEVTVNQSLLAPL----NL
EIDPSLQK--VRKEEKEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWSILQDHKTT-----KA-NI--DPLFE-TYISSLRRQLECLGG
ERGRLETELKS-MQDVVEDFKNK-YEDEINRRTA---AENEFVVLK--K---DVDAAYMN
KVELEAKVDALTDEINFLRAFYEA-----ELAQLQAQISET----SVVLSMDNNRKLDLD
SIIA-EVKAQYEDIAN-RSRAEAESWYQSK--YEELQLSAGRHGDDLRTTRMEISELN--
RMIQRLRSE-I--DNLKK------------------------------------------
-----Q-CA--TLQAAIADAEQ-RGELAL-KDARAKL----AELEDALQKAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEE--------------------------C-RLT-G
EGVGP---V--------NISVVTSAGSTGYGGSG--------------------------
-G----VC-MGGGGL--------------------------SSSLCYGS-----GVGGFS
STSGR-SMGGSS------------------------------------------------
--------SSMRIISKTSSTKKSYRS----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MIA------RQQGVRSGSRAFSSGSAVVGG-----GKRV-AFSSAS-VSG--GA----
-----------------------------------------GRCS-SGGFGSRSLYNFRG
N-KNICSV-AGSR--QGAGFGYA---------------------------GGFGG-----
-----------------------------AGSFGAGFGAGGFGGGFG-------------
----------G-SFN--GRGGSGFP-VC--PAGGI------QEVTINQSLLTPL----QV
EIDPEIQK--VRTEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWKLLQQQTTTT----SPRNL--DPFFE-AYISALRKQLDALAS
EKGRMLSELKM-MQDSVEDFKTK-YVSRKYTALP---CTCCF------------------
-------------PMAQAPSCSPV-----ELSQMQSHVSDT----SVVLSMDNNRDLDLD
SIIA-EVRAQYEEIAQ-RSKAEVEAWYQTK--VG NGMMGALV------------------
GSKEGTAAD-R--PFLCS------------------------------------------
-----Q-CQ--TLQTSVADAEQ-RGELAL-KDAYSKR----TELEAALQKAKEELTRMLR
EYQELLSVKLALDVEIATYRKLLEGEE--------------------------C-RMS-GECQS-A--V--------SICIGGGLNIGG----------------------------------------------------------------------------------------------GFGLGSG--------------FGSGCGSG---------------------------------------------------------------------------------------FGFSG--------------------GVSGSSGNKII----STT----------------------------------------------------------------------------------------SLT-RRSQL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Q-CQ--TLQTSVADAEQ-RGELAL-KDAYSKR----TELEAALQKAKEELTRMLREYQELLSVKLALDVEIATYRKLLEGEE--------------------------C-RMS-G
ECQS-A--V--------SICIGGGLNIGG-------------------------------
------------------------------------------------------------
---GFGLGSG--------------FGSGCGSG----------------------------
-----------------------------------------------------------F
GFSG--------------------GVSGSSGNKII----STT------------------
------------------------------------------------------------
----------SLT-RRSQL-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
-TM-SIKSTMK--SQNI-SHHGFSASSARVPG-----VCRS-GFSSVS-VSRSRG--S-G
GLGGA---------------------------CG------------GAGFGSRSLYGLGG
S-KRISIGGG-SCA-----ISGG-------------YGG--RV----GGGFGYGGGA-S-
--------------SGFGFG--GAAGGGFGLGGGPGF-----------------------
---------AG-GYGSSGFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPAIQR--VRKEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWELLQEQGSK----TVRQNL--EPFFD-TYINDLRRQLDSITT
ERGRLDAELRN-MQDVVEDFKVR-YEDEINKRTA---AENEFVALK--K---DVDSAYMN
KVELEAKVNSLTDEINFFRMLFEA-----ELSQMQTQVSDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEDIAN-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEISEMN--
RVIQRLRAE-I--DSVKK------------------------------------------
-----Q-CS--SLQTAIADAEQ-RGELAL-KDARAKL----VDLEEALQKAKQDMARLLR
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VS-PVNIS--------VVTSTV----------------------------------
------------SSGYGGGS--SLG-----------------------------------
---------------------------------------GGSLGLSGGSG----YSFTT-
-----------------------SV-------GHNLG--S--GLGG-------------S
SFSAS---SSRGLGS------------SGSSVKFV----STTS-----------------
------------------------------------------------------------
------------SSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
-----------------------------------------------------------M
KSSLSRKTYST--------KGGFSSSSASGG---GRPRAHT-SFSSVT-MSRSSGSGGG-
--------------------------D--------------RCTSIRGGLGSRSLYNLGD
N-RTISIRLAGGGSPG-RAL----------------------------------------
--------------GGFGLS------------------SGAYM-----------------
-------GLG-------TGRQSFGP-AC--PPGGI------QEVTVNQSLLTPL----NV
EIDPEIQR--VRTQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQGQSAG--TTRSNL--EPLFE-AYLSNLRRTLDKIQG
ERGRLDSELRN-MGDLVEDFKNK-YEDEINKRTA---AENEFVVLK--K---DVNAYYMG
LMDLHGRAGALTDKIDFFHLLFEM-----ERSQVQTHVSDT----NVVLSMDNNRSLDLD
SIIA-EVKAQYEDIAN-RSRAEAESWYQTK--YEELQVTASKHGDNLRDTKNEISELT--
RTVQRXXXX-X--XXXXX------------------------------------------
-----X-CQ--QLQAAIADAEQ-RGDLAL-KDAQKKF----GDLDVALHQAKEELARLLR
DYQALMNVKLSLDIEIATYRTLLEGEE--------------------------S-RMS-G
ECQSA---V--------SISVTGNSTSVSG------------------------------
-----------------GG--------------SAGIGGGMSWGGG---G----IKGGFS
TN----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------AV--RS-----------------------------------
---------------AYG------------------------------------------
----------------G-------P-----VGAGI------REVTINQSLLAPL----RL
DADPSLQR--VRQ EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-LLETKWTLLQEQKSA-----KSSRL--PDVFE-AQIAGLRGQLEALQV
DGGRLEAELRS-MQDVVEDFKNK-YEDEINRRAA---AENEFVVLK--K---DVDAAYMS
KVELEAKVDALNDEINFLRTLNEM-----ELTELQSQISDT----SVVLSMDNSRSLDLD
SIIA-EVKAQYEEMAK-CSRAEAEAWYQTK--FETLQAQAGKHGDDLRNTRNEISEMN--
RAIQRLQAE-I--DNIKN------------------------------------------
-----Q-RA--KLEAAIAEAEE-RGELAL-KDARAKQ----EELEAALQRAKQDMVRQLR
EYQELMSVKLALDIEIATYRKLLEGEE--------------------------S-RLA-G
D-------G--------VGA-----VN---------------------------------
-ISVVNST-GG-----SSNG----------------GGIGLTLGG-----TMGSNALSFS
SS-----AGPGP------------------------------------------------
--------LKAYSIRTTSTSRRSARN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
----------------------------------------------------------MR
SSLSQRQTYST--------KGGFSSNSASGG---GGNRTHT-SFSSVT-MSRSSGSGS--
------------------------------GA---------RCGPSSGGFGSRSLYNLGG
--KNISVSMAGGASSG-RTL----------------------------------------
--------------GGFGLG------------------SGAYM-----------------
-------GLG-------SARQTFGP-VC--PPGGI------QEVTVNQSLLTPL----NV
EIDPEIQR--VRTQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWTLLQEQSQNSG--VTRNNL--EPVFE-SYLSSLRRLLDSKQG
ERGRLELELRS-VQDNLDDFKNK-YEDEINRRTA---LENEFVVLK--K---DVDAAYMG
RMDLTGKVDSFTQEIEFLQHLHEV-----ELSQVQTHASDT----NVVLSMDNNRSLDLD
SIIA-EVRAQYEEIAQ-RSRAEAESWYQTK--YEELQVTAGKHGDNLRDTKNEIAELT--
RTIQRLQGE-L--DAAKK------------------------------------------
-----Q-CQ--QLQTAIAEAEQ-RGELAL-KDAKKKL----GDLDTALHQAKEDLARMLR
DYQALMNVKLALDVEIATYRKLLESEE--------------------------S-RMS-G
ECPSA---V--------SISVTGNSTTISG------------------------------
-----------------GS--------------AAGFGSGLSFSGG---GK--ACKGGFC
AN----------------------------------------VGYGT----------T--
KGGPVSG--GTSILRKT--TTVKTSSRRY-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQSTVS--FR-SGGSRSFSTASAITPS-----VSRT-SFTSV---SRSGGG-GGG
GFGRVS--------------------------LG-------------GAYGARSLYNLGG
S-KRISISAS----GG--GFRNR-------------FGAG--A----GGGYGFGGGA-G-
--------------SGFG------------------------------------------
--------FGG-GVGGPGFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPTIQR--VRTEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVRQNL--EPLFE-QYINNLRRQLDGILG
ERGRLDSELRN-MQDLVEDFKNK-YEDEINKRTT---AENEFVMLK--K---DVDAAYMN
KVELEAKVDALMDEINFMKMFFDA-----ELSQMQTHVSDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEDIAN-RSRTEAESWYQTK--YEELQQTAGRHGDDLRNTKHEISEMN--
RMIQRLRSE-I--DNVKK------------------------------------------
-----Q-CA--NLQNAIADAEQ-RGELAL-KDARNKL----AELEDALQKAKQDMARLLR
EYQELMNTKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VG-PV-------N-ISVVTNTV----------------------------------
------------SSGYGGGS-G--------------FGG--GLGGGLGGG----L-----
-----GGGLGGGGSSSYGGGSGFGGGLG----GGLGGGLGGGLGGGG-SS----SFY-S-
-----------------------SSSG-----GVGLG--GGLGVGG-------------S
GFSAS---SGRSLGFG--S----GGG-SSSSVKFV----STTS-S---------------
------------------------------------------------------------
-------------SRKSFKS----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MNRQVCKK--SF-SGRSQGFSGRSAMVS-G-----SSR-M-SC---VARSGVA-G--
-----GG-------------------------ACGFR----SGA---GGFGSRSLYNLGG
N-KSISISVAAGGS-RAGGFVGGQS------SCG--FAGGYGGG----FGGSYGGGFGGG
--R--GIGSGFG-------------------------------GAGGFGGAGGF------
GGPSVFGGLG--SFGS---PGGFVP-GG--FSGGI------QEVTINQSLLQPL----NV
EIDPQIGQ--VKA QEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWELLQQQTTG----LGPSSL--EPCFE-SYINFLCKQLDSLLA
ERGNLEGELKS-MQDLVEDFKKK-YEDEINKRTA---AENEFVGLK--K---DVDAAFMN
KVELQAKVDSLTDEVSFLRTLYEM-----ELSQMQSHVSDT----SVVLSMDNNRCLDLD
NIIA-EVRAQYEEIAQ-RSKAEAEALYQSK--LGELQTTAGRHGDDLKNTKSEIMELN--
RMIQRLRAE-I--ENVKK------------------------------------------
-----Q-NA--NLQTAISEAEQ-RGEMAL-KDANAKL----QDLQAALQKAKDDLARLLR
DYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RMS-G
ECQSA---V--------CISVVSNVTST--------------------------------
---------SGSSGSSRGVFGGVSGS--------GGYRGGVSGG----------------
-------------------SSSA-YGAVSG---------GSSSS-YGGVS-SG---ST--
GGRGSSGGYQ--------------------SSSS------GSRLGGAGSMS---MSHSGM
GSSSG--SV-QTSGGSGYKS----GGGGSTSIRFS----QTT------------------
------------------------------------------------------------
----------SSS-QHNSTK----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
H-------------F---SSPVFTSRSAAFSGR----GAQV-RLSSA----RPGG-----
----------------------------------------------LG-S--SSLYGLG-
------------AS-RPRVAV--RS-----------------------------------
---------------AYG------------------------------------------
----------------G-------P-----VGAGI------REVTINQSLLAPL----RL
DADPSLQR--VRQ EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-LLETKWTLLQEQKSA-----KSSRL--PDVFE-AQIAGLRGQLEALQV
DGGRLEAELRS-MQDVVEDFKNK-YEDEINRRAA---AENEFVVLK--K---DVDAAYMS
KVELEAKVDALNDEINFLRTLNEM-----ELTELQSQISDT----SVVLSMDNSRSLDLD
SIIA-EVKAQYEEMAK-CSRAEAEAWYQTK--FETLQAQAGKHGDDLRNTRNEISEMN--
RAIQRLQAE-I--DNIKN------------------------------------------
-----Q-RA--KLEAAIAEAEE-RGELAL-KDARAKQ----EELEAALQRAKQDMVRQLR
EYQELMSVKLALDIEIATYRKLLEGEE--------------------------S-RLA-G
D-------G--------VGA-----VN---------------------------------
-ISVVNST-GG-----SSNG----------------GGIGLTLGG-----TMGSNALSFS
SS-----AGPGP------------------------------------------------
--------LKAYSIRTTSTSRRSARN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
----------------------------------------------------------MR
-SSMSRHMSST--------KGGFSSCSASGG---AGARART-SFSSMT-MSRSSSGGVG-
--------------------------S--GVP---------RCGPSRGSFGSRSLYNLGG
S-KGISVSMAGGACSG-RTL----------------------------------------
--------------GGFGLG------------------SGIYG-----------------
-------GLG-------ASRQTFGP-AC--PPGGI------QEVTVNQSLLTPL----HV
EIDPEIQR--VRTQEKEQIKCLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQGQNSG--AGKNSL--EPVFE-AYVCNLRRQLDTLQG
ERGRLDSELRN-VQDLVEDFKNK-YEEEINKRTA---AENEFVVLK--K---DVDAAYMG
QMDLYGQVSTLTQETDFLRHLYDM-----ELSQVQTHVSDT----SVVLSMDNNRHLDLD
SIIA-EVKAQYELIAQ-RSRAEAEAWYQTK--YEELQVTAGKHGDSLRDTKNEIAELT--
RTIQRLQGE-A--DAAKK------------------------------------------
-----Q-XX--XXXXXXXXXXX-XXXXXX-XXXXXXX----XXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXX--------------------------X-XMS-G
ECPSA---V--------SISVTGTSTTTCG------------------------------
-----------------GGSSG-----------AAGFGGGFSLGGG---CG--GG---GA
NK----------------------------------------GGFST----------V--
KGGPASG--GSSILRRT--TTVKTSSRRY-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
--------------------------------------------------------MESM
R--VTQKSYE--VH---LWPPGLQQPLLHQRPS-----SRI-SSSSF-------------
-------------------------------------------------------SRA-G
S---------------------SS-----------SFRGG------------LGL-----
------------------------------------------------------------
--------------------------------GGI------TAVQ---------------
-------A--VHI--QEKIKNLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQQ-QKT-----SRSNM--GNMFESGA-------------
---------WQ-HAGDVEDFKNE-YEDEINKRTE---MENEFALIK--K---DVDEAYMN
KVELESRLEGLTDEINFFRQLYEE-----EIRELQLQISDT----SVVLSMDNGRSLDLD
GIIA-EVKAQYEEIAN-RSRAEAESTYQIK--YEELQTLAGKHGDDLRRTKSEISE----
-------AE-I--EALKG------------------------------------------
-----Q-RA--ALEAAIADAEQ-RGEMAI-KAANAKL----ARLESALQKARQDMARQLR
EYQELVNVKLALDIEIATYRKLLEGEEN---------------------------RLE-A
---GM---Q--------NLSMHTKTSSG--------------------------------
---------------YAG---------------------MVSS-----------------
---PYG------------------------------GLTSPGFTR---------------
------------------------------------------------------------
-------------------------TKSAVVVKKI------ET----LVTETSDVLPR--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MIARQQCVR-----G-GSRGFSCGSAIVGGG----KRG--AFSSVS---VSGGA----
-----------------------------------------GRCS-SGGFGSRSLYNLGG
N-KSISMSVAGSRQ-GA-CFGGAGG-----------FGT---------------------
---------------------------------------GGFG-----------------
---GGFGG----SFS--GKGGPGFP-VC--PAGGI------QEVTINQSLLTPL----HV
EIDPEIQK--VRTEEREQIKLLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWKLLQQQTTST----SSKNL--EPLFE-TYLSVLRKQLDTLVN
DKGRLQSELKT-MQDSVEDFKTK-YEEEINKRTA---AENDFVVLK--K---DVDAAYMN
KVELEAKVDSLNDEINFLKVLYDA-----ELSQMQTHVSDM----SVVLSMDNNRNLDLD
SIIA-EVRAQYEEIAQ-RSKAEAEALYQTK--VQQLQISVDQHGDNLKNTKSEIAELN--
RMIQRLRAE-I--ENIKK------------------------------------------
-----Q-CQ--TLQASVADAEQ-RGENAL-KDAHSKR----IELEAALQQAKEELARMLR
EYQELMSVKLALDIEIATYRKLLEGEE--------------------------C-RMS-G
ECQSA---V--------SISVVGGSTSTGG------------------------------
---------------ISG-G---LGS-----------------------------GS---
---GFGL------------------------SSGFGSG--SGSGFGF--G-GS-------
----VSGSSSSKIISTTTLNKRR-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSSKSTVR--TH-SSSRRAFGAGSARLPG-----VSRS-GFSSVS-VSRSGGS-GLG
G-------------------------------VC-----------GGAGLGSRSLHGLGS
S-QRVSVGGG----SC--AVGGR-------------YGG--RV----GGGFGLGGGT-G-
--------------SGCGFG--GG--A------GA-----------------GF----GL
G--GG-AGCAG-GYGGPGFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPSIQR--VRT EEREQIKTLNNQFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVRQSL--EPLFE-QYINNLRRQLDSILG
EKGRLDTDLRA-MQDTVEDFKNK-YEDEINKRTA---AENEFVTLK--K---DVDAAYMN
KVELQAKADSLTDEINFLRAFYDA-----ELSQMQTHISDT----SVVLSMDNNRSLDLD
SIIA-EVRAQYEEIAQ-RSRDEAESWYQTK--YEELQVTAGRHGDDLRSTKQEIAEIN--
RTIQRLRSE-I--DHVKK------------------------------------------
-----Q-CA--NLQAAIADAEQ-RGEMAL-KDAKGKL----EELEDALQKAKQDMARLLK
DYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLN-G
EG--VG-PV-------N-ISVTQSTV----------------------------------
------------SSGYGSASG-------------------------V-------------
---------------------------------------GSGLGLGGGSG----YS----
-----------------------YGSG--------------HSLG--------------G
GFSSG---SGRVLG--GGLS--SVGGS-SSSIKYT----TTTS-S---------------
------------------------------------------------------------
--------------SSKP------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQSSVS--FR-SGGSRSFSTASAITPS-----VSRT-SFTSV---SRSGGG-GGG
GFGRVS--------------------------LA-------GACGV-GGYGSRSLYNLGG
S-KRISISTS----GG--SFRNR-------------FGAG--A----GGGYGFGGGA-G-
--------------SGFGFG--GGAG--------G-----------------GF----GL
G--GGA-GFGG-GFGGPGFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPSIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVRQNL--EPLFE-QYINNLRRQLDSIVG
ERGRLDSELRN-MQDLVEDFKNK-YEDEINKRTT---AENEFVMLK--K---DVDAAYMN
KVELEAKVDALMDEINFMKMFFDA-----ELSQMQTHVSDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEEIAN-RSRTEAESWYQTK--YEELQQTAGRHGDDLRNTKHEISEMN--
RMIQRLRAE-I--DNVKK------------------------------------------
-----Q-CA--NLQNAIADAEQ-RGELAL-KDARNKL----AELEEALQKAKQDMARLLR
EYQELMNTKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VG-PV-------N-ISVVTSSV----------------------------------
------------SSGYGSGS-G--------------YGG--GL----GGG----L-----
---------GGGL--------------------------GGGLA-GGSSG----SYYSS-
------------------------SSG-----GVGLG--GGLSVGG-------------S
GFSAS---SGRGLGVGFGS---GG-G-SSSSVKFV----STTS-S---------------
------------------------------------------------------------
-------------SRKSFKS----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--M-SRQSSIT--FQSG-SRRGFSTTSAITPA-----AGRS-RFSSVS-VARSAA--GSG
GLGRIS--------------------------SA------------GASFGSRSLYNLGG
A-KRVSINGC-GSS-----CRSG-------------FGG--RA----SNRFGV-----N-
--------------SGFGYG--GGVGGGF-------------------------------
--------------SGPSFP------VC--PPGGI------QEVTVNQSLLTPL----HL
QIDPTIQR--VRA EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQGSR----TVRQNL--EPLFD-SYTSELRRQLESITT
ERGRLEAELRN-MQDVVEDFKVR-YEDEINKRTA---AENEFVALK--K---DVDAAYMN
KVELEAKVKSLPEEINFIHSVFDA-----ELSQLQTQVGDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEDIAN-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEISEMN--
RMIQRLRAE-I--DSVKK------------------------------------------
-----Q-CS--SLQTAIADAEQ-RGELAL-KDARAKL----VDLEEALQKAKQDMARLLR
EYQELMNIKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VS-PVNIS--------VVTSTL----------------------------------
------------SSGYGSGS--SIG-----------------------------------
---------------------------------------GGNLGLGGGSG----YSFTT-
-----------------------SG-------GHSLG--A--GLGG-------------S
GFSAT---SNRGLGG------------SGSSVKFV----STTS-----------------
------------------------------------------------------------
------------SSQKSYTH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MIARQQGVR-----G-GSRGFSVGSAIVGGG----KRG--AFSSVS---VSGGA----
-----------------------------------------GLRC-SGGFGSRSLYNLGG
N-KSISMSVAGSRQ-GT-SFGGAGG-----------FGT---------------------
---------------------------------------GGFG-----------------
---GGFGG----SFS--GRGGPGFP-VC--PAGGI------QEVTINQSLLTPL----HV
EIDPEIQK--VRT EEREQIKILNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQQQTTTT----SSKNL--EPFFE-TYLSALRQQLDTLAN
DKGRLQSELKT-MQDSVEDFKTK-YEEEINKRTA---AENDFVVLK--K---DVDAAYMT
KVELEAKVDSLNDEINFLRVLYDA-----ELSQMQTHVSDT----SVVLSMDNNRCLDLD
SIIA-EVRAQYEEIAQ-KSKAEAEALYQTK--VQQLQISVDQHGDNLKNTKTEIAELN--
RMIQRLRAE-I--ENIKK------------------------------------------
-----Q-CQ--TLQTSVADAEL-RGENAL-KDAYSKR----TELEAALQQAKEELARILR
EYQELMSVKLALDVEIATYRKLLEGEE--------------------------S-RMS-G
ECQSA---V--------SISMVGGGASTGG------------------------------
---------------IAR-G---LGS-----------------------------SS---
---GFGL------------------------GSGFGSG--SGSGFGF--G-GG-------
----VSGSSGSKIISTTSLTKKSYR-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
----------------------------------------------------------IE
QATMSRISYR---SSTGGGMRGFSSGSAIVGG-G--SGTRS-SFSSVS-VSRVGGGRA--
-------------------------------------GG-GGGFGAGGGFGSRSLYNLGG
S-KRISYSSVGGGL-RSG-AGGGYG-----------F--GGGAG--------FGLG----
-------YG--GG-AGAGFGLGGAG-GGGGY---------------G--M----GGGFGL
GGP---------GFG--GRGGPGFP-VC--PPGGI------HEVTVNQSLLAPL----KL
DIDPEIQK--VRTHEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWSLLQEQGHTV----TRKSL--EPLFE-AYINNLRRQLDSLMG
ERGRLDSELRN-MQDMVEDFKNK-YEDEINRRTS---AENEFVVLK--K---DVDGAYMN
KVELQAKADALADEINFLRALYEA-----ELSQMQQQVSDT----SVVLSMDNNRRLDLD
SIIA-EVKAQYEDIAN-RSRAEAEAWYQNK--YEELQVSAGRHGDDLRNTKIEISEIN--
RMVQRLRNE-I--ESVKK------------------------------------------
-----Q-CA--NLKAAIADAEE-RGELAL-KDAKAKL----AELEDALQQAKADLARQLR
EYQELMNVKLALDIEIATYRKLLEGEE--------------------------C-RLA-G
DGVP----V--------NISVTRTTVGTGY------------------------------
------------GGGSNL--SMGGGI----CNMGNSFSCGSGP------GGYGRFGGGFG
SRSLYNVGGCNRI------------SVAGR-G----GGFYGPAGFGAGT--GMSYGFGGA
SGGAFG---FG--------------GGIF-GGSS------GIGGGVCAGGMGFGSFGSGG
QGMAG--S--------CV--VG----GSSSSMKYV----SST------------------
------------------------------------------------------------
----------SSS-KRC-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQSSVS--FR-SGGSRSFSAASAITPS-----VSRT-SFSSV---SRSGGG--G-
GGGRVS--------------------------LG-------GA-YGAGGYGSRSLYNVGG
S-KRIAFSSG----GG--SFRNR-------------FGA---------GSFGFGGGA-G-
--------------SGFGFG--GGAG-S------------------------GY----GF
G--GGAGFG-G-GYGGAGFP------VC--PPGGI------QEVTVNQNLLTPL----NL
QIDPTIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVRQNL--EPMFE-QYISNLRRQLDGVLG
ERGRLDSELRN-MQDLVEDFKNK-YEDEINKRTT---AENEFVMLK--K---DVDAAYMN
KVELEAKVDALMDEINFMKMFFDA-----ELSQMQTHVSDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEDIAN-RSRTEAESWYQTK--YEELQQTAGRHGDDLRNTKHEISEMN--
RMIQRLRSE-I--DNVKK------------------------------------------
-----Q-CA--NLQNAIADAEQ-RGELAL-KDARNKL----TELEEALQKAKQDMARLLR
EYQELMNTKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VG-PV-------N-ISVVTNSV----------------------------------
------------SSGYGGGS-LGFGG----G---SSFGGGSGFGGGLGSG----L-----
-----G----------------------------------------GGGG----GSYYS-
-----------------------SSSG-----GAGLG--GGLSVGG-------------S
GFSAS---SGRGM--GFGS----GGG-SSSSVKFV----STTS-S---------------
------------------------------------------------------------
-------------SRRSFKS----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSV
R--VTQKSYK--VP--TSGPQAFSSRSYTSGPS-----ACI-SSSSF-------------
-------------------------------------------------------SRVGS
-----------------------S-----------SFRGG------------LGG-----
---------------GCG------------------------------------------
-----------------GASG----------TGAI------TTVTVNQSLLSPL----NL
EVDPNIQV--VRA QEKEQIKSLNNKFASF------IDK--VQ------------------
----FLEQQNK-IL------RQQ-QKM-----ARSNT--NNLLE-SYINNLRPQLETLGQ
EKLKLEAELGN-MQGLVEDFKNK-YEDEVNKLTE---MEDEFVLIE--K---DVDEAYMN
KAELGSHLEGLTDEINFLRQLYEV-----EIPELQSQISDT----SVVLSKENSRSLGMD
SIIT-EVKVQYEEIAK-RSQAEADS-------YEVLQTLAGKHGNDLRRTKTEISEMN--
RNICGLQAE-T--EGLKG------------------------------------------
-----Q-TA--SPKAAIADAEQ-HGELSV-KDANAKL----SELEAAQQRAKQDMTRRLH
EYKELMNIKLALDIEIATYRKLPEGEES---------------------------RLE-S
---GM---Q--------NRSTHAKTSSS--------------------------------
---------------YAG---------------------GLSS-----------------
---AFG------------------------------GLTSPRLSCSLG------------
---------------------------------S--------GFDSGV---------GSS
SFSST-------------------SSTRAVVVKKI------QTRDGKLE--SSDALPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQSSVS--FR-SGGSRSFSAASAITPS-----VSRT-SFSSV---SRSGGG--G-
GGGRVS--------------------------LG-------GT-YGAGGYGSRSLYNVGA
S-KRISFSSS----GG--SLRNR-------------FGPGA------GPMFGFGGGA-S-
--------------SGFGFG--GGAG-G------------------------AF----GF
G--GGAGFG-G-GYGGAGFP------VC--PPGGI------QEVTINQNLLTPL----NL
QIDPTIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVRQNL--EPLFE-QYISNLRRQLDGVLG
ERGRLDSELRN-MQDLVEDFKNK-YEDEINKRTT---AENEFVMLK--K---DVDAAYMN
KVELEAKVDALMDEINFMKMFFDA-----ELSQMQTHVSDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEDIAN-RSRTEAESWYQTK--YEELQQTAGRHGDDLRNTKHEISEMN--
RMIQRLRSE-I--DNVKK------------------------------------------
-----Q-CA--NLQNAIADAEQ-RGELAL-KDARNKL----TELEEALQKAKQDMARLLR
EYQELMNTKLSLDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VG-PV-------N-ISVVTNSV----------------------------------
------------SSGYGGGS-LGLAG----G---SGFG----------SG----L-----
-----G----------------------------------------GGGG----SSYYS-
-----------------------TNSG-----GVGLG--GGLSVGG-------------S
GFSAS---SGRGMGGGFGS----AGG-SSSSVKFV----STTS-S---------------
------------------------------------------------------------
-------------SRRSFKS----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQSSVS--FR-SGGSRSFSTASAITPS-----VSRT-SFTSV---SRSGG--GGG
GFGRVS--------------------------LG-------GACGV-GGYGSRSLYNLGG
S-KRISISTS----GG--SFRNR-------------FGAG--A----GGGYGFGGGA-G-
--------------SGFGFG--GGAG--------G-----------------GF----GL
G--GGA-GFGG-GFGGPGFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPSIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVRQNL--EPLFE-QYINNLRRQLDSIVG
ERGRLDSELRN-MQDLVEDFKNK-YEDEINKRTT---AENEFVMLK--K---DVDAAYMN
KVELEARVDALMDEINFMKMFFDA-----ELSQMQTHVSDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEEIAN-RSRTEAESWYQTK--YEELQQTAGRHGDDLRNTKHEISEMN--
RMIQRLRAE-I--DNVKK------------------------------------------
-----Q-CA--NLQNAIADAEQ-RGELAL-KDARHKL----AELEEALQKAKQDMARLLR
EYQELMNTKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VG-PV-------N-ISVVTSSV----------------------------------
------------SSGYGGGS-G--------------YGG--GLGGGLGGG----L-----
-----G----GGL--------------------------GGGLS-GGGSG----SYYSS-
------------------------SSG-----GVGLG--GGLSVGG-------------S
GFSAS---SGRGLGVGFGS---GG-G-SSSSVKFV----STTS-S---------------
------------------------------------------------------------
-------------SRKSFKS----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQSSVS--YR-SGGARSFSAASAITPS-----VSRT-SFTSV---SRSGG--GGG
GFGRLS--------------------------LA-------GAGGA-SGYGSRSLYNLGG
S-KRISISSS----GG--SFRNR-------------FG----A----GGGYGFGGGA-G-
--------------SGFGFG--GGAGSGF-G-LGG-----------------GA----GF
G--GGFGGPGG-GFGGPGFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPSIQR--VRTEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWALLQEQGTK----TVRQNL--DPLFE-QYINNLRRQLDSIVG
ERGRLDSELRN-MQDLVEDFKNK-YEDEINKRTT---AENEFVMLK--K---DVDAAYMN
KVELEAKVDALMDEINFMKMFFDA-----ELSQMQTHVSDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEEIAN-RSRTEAESWYQTK--YEELQQTAGRHGDDLRNTKHEISEMN--
RMIQRLRSE-I--DNVKK------------------------------------------
-----Q-CA--NLQNAIADAEQ-RGELAL-KDARNKL----AELEDALQKAKQDMARLLR
EYQELMNTKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VG-PV-------N-ISVVTSNV----------------------------------
------------SSGYGGGS-G--------------FGG--GLGGGFGGG----L-----
-----GGGLGGG------------------------------LGGGSGGG----SYYSS-
-----------------------S--------SGGVG--GGLSVGG-------------S
GFSAG---SGRSLGVGFGS---GG-G-SSSSVKFV----STTS-S---------------
------------------------------------------------------------
-------------SRRSVRN----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------FLASSRISVRFSLLASTPASTMST
R-V-TQKTYK--VST--SGPRAFSSRSYSSGPG-----TRI-SSSSF-------------
-------------------------------------------------------SRVGS
-----------------------------------SYRGG------------LGTSM---
--------------SL---A----------------------------------------
---------------GGYGG-AG-------GMGSI------TAVQVNQSLLSPL----KL
EVDPNIQA--VRNQEKEQIKTLNNKFASF------IDK--VR------------------
----SLEQQNK-ILETKWSLLQQ-QKT-----TRSNM--DNMFE-SYINNLRRQLDTLGQ
EKLRLEAEFGN-MQGLVEDLKNK-YEDEINKRTE---MENEFVLIK--K---DVDEAYMN
KVELESRLEGLTDEINFYRQLYEE-----EIRELQSQISDT----SVVLSMDNNRSLDLD
GIIA-EVKAQYEDIAN-RSRAEAETMYQIK--YEELQTLAGKHGDDLRRTKTEISEMN--
RNISRIQAE-I--EGLKG------------------------------------------
-----Q-RA--SLEAAIADAEQ-RGEMAI-KDAQSKV----AELEAALRNAKQDMARQLR
EYQELMNVKLALDVEIATYRKLLEGEEN---------------------------RLE-S
---GM---Q--------NMSIHTKTTSS--------------------------------
---------------YSGVSLPI-------------HCGLMSP-----------------
---SYG-----------------------------------NLNYGLG--------FQ--
---------------------------------A--------NLGSGG---------SSG
SFSRT-------------------SSSKTVVVKKI------ETRDGKLVSESSDVLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
----------------------------------------------------KFQSFCSS
TMSVSRQ-T----VYSTGGTKRFSASSAVPSG-----GTRS-SFSTLS-VSRAGGG----
--------------------------------------GGRASYGGYGGFGSRSLQNAGG
S-RRIAVSYGAPSH-FGF-KS---------------------------------------
--------------SGIESH------IGGNY--GSD-------------M----MSG---
---------IG-MGQG-PFGGPGFP-VC--PPGGI------QEVTVNQTLLAPL----NL
EIDPSIQR--IRTEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQEQGVKS----VKCNI--DPLFE-AYISALRRQLDSLLS
EKVRLDSDLRQ-MQDAVEDYKKK-YEDEINKRTS---VENEFVVLK--K---DVDAAYMN
KVELEAKLNALTDEINFLRAVYEA-----EIAQMQTQISDT----SVVLSMDNNRTLDLN
GIIA-EVKAQYEDIAN-RSRAEAESWYQTK--YEELQQSAGRHGDDLRSTKTEISELN--
RMINRLRSE-I--DSVKK------------------------------------------
-----Q-CA--KLQAAITEAEE-RGELAL-KDAKKKL----ADLEEALQKCKQEMARQLR
EYQELMNVKLSLDVEIATYRKLLEGEE--------------------------C-RLA-G
EGVG-P--V--------NISVVSSSYGGG-------------------------------
-------------SGSGSGYGMGGGS----GFGG-----------------GSGFG----
AGSGYAIGG---------------------------------------------------
-------------------------GQSF-GGGS-----------VSGGM--------GG
ASFSV--SS-G-KM-AAFGPGS----GSSSNVKII----SKT------------------
------------------------------------------------------------
----------STS-SRKL------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------Q--VKAQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQQQGTSSI--SGTNNL--EPLFE-NHINYLRSYLDNILG
ERSRLDSELRN-MQDLVEDFKKK-YEDEINKRTA---AENEFVTLK--K---DVDTAYMN
KVELQAKVDALLDEIDFLRTLYNA-----ELSQMQSHVSDT----SVVLSMDNNRSLDLD
SIIA-EVRAQYEDIAQ-RSKAEAEALYQTK--LGELQTTAGRHGDDLRNTKSEIIELN--
RMIQRLRAD-I--ENVKK------------------------------------------
-----Q-NA--NLQTAIAEAEQ-RGEMAL-KDANAKL----QDLQAALQQAKDDLARLLR
DYQELMNVKLALDVEIATYRKLLEGEEY---------------------------RMS-G
EC--PS-AV-------S-ISVVSSSS----------------------------------
------------ATSASGG-GY--------------------------------------
---------------------------------------GARYGVS--------------
--------------------------------------------G--------------G
GFSSA---SNR-----------------SGSIKLS----QSSQ-----------------
------------------------------------------------------------
------------RYSR--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
-------------------------------------------------------SLHSS
WATMSHQAT----VKI--QRKGFSNSSAILPS-----TSRT-SFSSRT-VSRGGSCSA--
G------------------------------------GAGFGRVGGGAGFGSRSLYNFGG
S-KRISGFGGVSG--AGY-CASIG------------------------------------
--------------GGYGLG------GGSSYGLGGG-------------I----GSG---
---------FG-VIGT-GFGGPGFP-VC--PPGGI------QEVTINQHLLTPL----NL
EIDPTIQK--VRKEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKLTLLQEQGQKT----CKSNI--EPLFE-MYINDLRKKLNNLEN
DRGRLLGELNN-IQNLVEDCKNK-YEDEINKRAT---AENDFVTLK--K---DVDAAYLN
KVELESKADSLNCEVNFLRALYEE-----ELAQMHTQISDT----SVVLSMDNNRNLDMD
SIIA-EVKAQYEDIAN-KSRAESETFYQCK--YEELQTAAGRHGDDLRNTKQEISEIN--
RHIHRLRAE-I--DNVKK------------------------------------------
-----Q-CA--NLQAAIAEAEE-RGELAL-KDARQKL----AELEDALQKAKQDMARQLK
EYQDLMNVKLALDIEIATYRKLLEGEE--------------------------C-RLA-S
DASG-A--V--------NISVVSSTVSRGG------------------------------
------------AAGCGIGYGGGSSL----SLGG-----------------GSGFG---V
GGGGLGIGS---------------------------------------------------
-------------------------GHGI-G---------------------------GG
SYSSA--SG-R-GIGGGMSLGG----GGSSSVKSV----KYV------------------
------------------------------------------------------------
----------STS-QKSYRS----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSTKTTIK--SQ--TSHRGYSASSARVPG-----LNRS-GFSSVS-VCRSRGSGGSS
A-------------------------------MC-----------GGAGFGSRSLYGVGS
S-KRISIGGG----SC--GIGGG-------------YGS--RF----GGSFGIGGG----
--------------------------A------GS-----------------GF----GF
G--GG-VGFGG-GYGGAGFP------VC--PPGGI------QEVTINQNLLTPL----NV
QIDPTIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWALLQEQGTK----TVRQNL--EPMFE-QYISNLRRQLDSIIG
ERGRLDSELRN-MQDTVEDYKSK-YEDEINKRTK---AENEFVTVK--K---DVDAAYMT
KVELQAKADSLADEINFLRVIYEA-----ELSQMQTHISDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEDIAQ-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEIAEIN--
RMIQRLRSE-I--DHVKK------------------------------------------
-----Q-CA--NLQAAIADAEQ-RGEMAL-KDARGKL----EGLEDALQKAKQEMARLLK
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLN-G
EG--VG-PV-------N-ISVVQSTV----------------------------------
------------SSGYGSAG-------------------GA--S----------------
----------------------------------------SSLGLGGS-S----SYSYG-
-------------------------SS--------------HGLG--------------G
GFSAG---SGRAIG--GGLS--SSGGLSSSTIKYT----TSAS-----------------
------------------------------------------------------------
------------SSRKSYRH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--M-SRLSTIT--FHSSGSRRGFSTASATTPT-----AGRS-RFSSVS-VARSSG--NSG
GLGRIS--------------------------GA------------GAGFGSRSLYNLGG
T-KRVSIGGCAGSG-----FRSG-------------FGG--RA----SSGFGV-----S-
--------------SGFGYG--GGIGGGF-------------------------------
--------------GGPGFS------VC--PSGGI------QEVTVNQSLLTPL----NL
QIDPTIQR--VRK EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQEQGSR----TVRQNL--EPFFD-AYLNDLRRQLDGVTA
ERGRLDAELRS-MQEVVEDFKVR-YEDEINKRAA---AENEFVGLK--K---DVDGAYMN
KVELEAKVDSLTDQINFYRMIYEA-----ELSQMQNQVSDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEDIAN-RSRAEAESWYQTK--YEELQLTAGRHGDDLRNTKQEIAEMN--
RMIQRLRSE-I--DGVKK------------------------------------------
-----Q-CT--SLQTAISDAEQ-RGELAL-KDARVKL----VDLEDALQKAKQDMARLLR
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VS-PVNIS--------VVTSTV----------------------------------
------------SSGYGAGS--NFG-----------------------------------
---------------------------------------GGSLGLGGNSG----YSFTT-
-----------------------SG-------GHSLG--TGTGLGG-------------S
GFTTS---SSRGPVG------------SGSSVKFI----STTS-----------------
------------------------------------------------------------
------------CSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
MA--STSTTIR--SH-SSSRRGFSAGSARLPG-----VSRS-GFSSVS-VSRSRGSGGLG
G-------------------------------AC-----------GGAGFGSRSLYGLGG
S-KRISIGGG----SC--AIGGG-------------YGS--RA----GGSYGFGG-A-G-
--------------SGFGFG--GG--A------GI-----------------GF----GL
G--GG-AGLAG-GFGGPGFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPAIQR--VRA EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVRQNL--EPLFE-QYINNLRRQLDSIVG
ERGRLDSELRN-MQDLVEDLKNK-YEDEINKRTA---AENEFVTLK--K---DVDAAYMN
KVELQAKADTLTDEINFLRALYEA-----ELSQMQTHISDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEEIAQ-RSRAEAESWYQSK--YEELQVTAGRHGDDLRNTKQEIAEIN--
RMIQRLRSE-I--DHVKK------------------------------------------
-----Q-CA--NLQAAIADAEQ-RGEMAL-KDAKNKL----EGLEDALQKAKQDLARLLK
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLN-G
EG--VG-QV-------N-ISVVQSTV----------------------------------
------------SSGYGGASG-------------------------V-------------
---------------------------------------GSGLGLGGGSS----YS----
-----------------------YGSG--------------LGVG--------------G
GFSSS---SGRAIG--GGLS--SVGGG-SSTIKYT----TTSS-----------------
------------------------------------------------------------
------------SSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQSSVS--FR-SGGSRSFSAASAITPS-----VSRT-SFTSV---SRSGG--GGG
GFGRIS--------------------------LG-------GAGGAGGGYGSRSLYNVGS
S-KRISMSTG----GG--SFRNR-------------FGG---A----GSGYGLGGGA-G-
--------------SGFGFG--GGAGGGF-G-FGG-----------------GS----GA
-------GFGG-GFGSTGFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPTIQR--VRTEEREQIKSLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTR----TVRQSL--EPLFE-QYINNLKRQLDGVLG
ERGRLDSELRN-MQDLVEDFKNK-YEDEINKRTT---AENEFVMLK--K---DVDAAYMN
KVELEARVDALMDKINFMKMFFEA-----ELSQIQTHVSDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEDIAN-RSRTEAESWYQTK--YEELQQTAGRHGDDLRNTKHEISEMN--
RMIQRLRAE-I--DNVKK------------------------------------------
-----Q-CA--NLQNAIADAEQ-RGELAL-KDARNKL----AELEDALQKAKQDMARLLR
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------Y-RLS-G
EG--VG-PV-------N-ISVVTNSV----------------------------------
------------SSGYGGGS-G--------------FGG--GLGGGLGSG----L-----
-----GSGLGG-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQSSVS--FR-SGGSRSFSAASAITPS-----VSRT-SFSSV---SRSGGG----
GGGRVS--------------------------LG-------GA-YGAGGYGSRSLYNVGG
S-KRISFSSG----GG--SFRNR-------------FGAGAGA----GGSFGFGGGA-G-
--------------SGFGFG--GGAG-S------------------------GF----GF
G--GGAGFG-G-GYGGAGFP------VC--PPGGI------QEVTVNQNLLTPL----NL
QIDPTIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVRQNL--EPLFE-QYISNLRRQLDGVLG
ERGRLDSELRN-MQDLVEDFKNK-YEDEINKRTT---AENEFVMLK--K---DVDAAYMN
KVELEAKVDALMDEINFMKMFFDA-----ELSQMQTHVSDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEDIAN-RSRTEAESWYQTK--YEELQQTAGRHGDDLRNTKHEISEMN--
RMIQRLRSE-I--DNVKK------------------------------------------
-----Q-CA--NLQNAIADAEQ-RGELAL-KDARNKL----TELEEALQKAKQDMARLLR
EYQELMNTKLALDVEIATYRKLLEGEE--------------------------C-RSI-S
-P--IP-PF-------S-TAVVTNSV----------------------------------
------------SSGYGGGS-LGFGG----G---SGFGGGSSFGGGLGSG----L-----
-----G----------------------------------------GG-G----GSYYS-
-----------------------SSSG-----GAGLG--GGLSVGG-------------S
GFSAS---SGRGM--GFGS----GGG-SSSSVKFV----STTS-S---------------
------------------------------------------------------------
-------------SRRSFKS----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MVSRQQYIR-----S-GSQGFSSGSAI-VGG----GRRA-AFSSIS---VSGGA----
-----------------------------------------GRCS-SGGFGSRSLYSLGG
N-KSTSISVAGGRQ-GA-GFGGGV------------------------------------
-----------FGAGSFG----------------AGFGAGSFG-----------------
---GGFGG----SFN--SRGGPGFP-VC--PAGGI------QEVTINQSLLTPL----RV
EIDPEIQK--IRTEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWKLLQQQTTTT----SSKNL--EPFFE-SYLSVLRKQLDGLIN
DKGRLQSELKA-MQDSVEDFKTK-YEGEINKRTT---AENDFVVLK--K---DVDAAYMN
KVELEAKVEALNDEINFLRVLYDA-----ELSQMQTHFSDT----SVVVSMDNNRSLDLD
SIIA-EVRAQYEEIAQ-KSKAEAEALYQTK--VQQLQISVDQHGDSLKITKSEIAELN--
RMIQRLRAE-I--ENVKK------------------------------------------
-----Q-CQ--TLQASVADAEQ-RGELAL-KDAYSKR----TELEAALQKAKEELARMLR
EYQELMSVKLALDIEIATYRKLLEGEE--------------------------Y-RMS-G
ECQSA---V--------SISVVGGGVSAGS------------------------------
---------------IG-GG---LS-----------------------------------
----LSG------------------------GFGSGSG--SGSGFGF--G-GG-------
----VSGSSGSKIISTTTLTKRS--HR---------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
-------------------------LRFSES------DTSR-M-SC---VARSGGG-G--
-----GG-------------------------AFGFR----SG---AGGFGSRSLYNLGG
N-KSISISVA--GS-RAGGFGGGRS------SCVSGFGSGYGGGYGGGFGG---------
-GR--GMGGGFGGAGGFG--------GAGGFGGA-----GG------------------F
GGLGGFGGPG--GF-G---PGGFGP-GG--FPGGI------QEVTVNQSLLQPL----NV
EIDPQIGQ--VKTQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWSLLQQQGTHPI--TGTNNL--EPLFE-NYINSLRSYLDSILG
ERGRLDSELRN-MQDLVEDFKKK-YEDEINKRTA---AENEFVTLK--K---DVDAAYMN
KVELQAKVDALTDEINFLTTLYDM-----ELSQMQSHVSDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEEIAQ-RSKAEAEALYQTK--LGELQTTAGRHGDDLKSTKSEISELN--
RVIQRLRAE-I--ENVKK------------------------------------------
-----Q-IA--KLQSAIAEAEQ-RGELAL-KDANAKL----QELQAALQQAKDDLARLLR
DYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RMS-G
ECPSA---V--------SISVVSSSS----------------------------------
-------TTSASAGGFGGGYGG-------------GVGVGGG------------------
----------------------------------------ARSGFGG--G--SGFGGG--
SGFGGGSGFGGGSGISGSSGFGGGSGSGFGG---------GSGFSGS-SG--FGGGSSGF
GSGSG--GR-SGVSGGGLSSG----SSRGGSVRFS----QSS------------------
------------------------------------------------------------
----------QRT-S---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSTKTTIK--SQ--TSHRGYSASSARVPG-----LNRS-GFSSVS-VCRSRGSGGSS
A-------------------------------MC-----------GGAGFGSRSLYGVGS
S-KRISIGGG----SC--GIGGG-------------YGS--RF----GGSFGIGGG----
--------------------------A------GS-----------------GF----GF
G--GG-AGFGG-GYGGAGFP------VC--PPGGI------QEVTINQSLLTPL----NL
QIDPTIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWALLQEQGTK----TVRQNL--EPMFE-QYISNLRRQLDSIIG
ERGRLDSELRN-MQDTVEDYKSK-YEDEINKRTA---AENEFVTLK--K---DVDAAYMN
KVELQAKADSLTDDINFLRALYEA-----ELSQMQTHISDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEDIAQ-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEIAEIN--
RMIQRLRSE-I--DHVKK------------------------------------------
-----Q-CA--NLQAAIADAEQ-RGEMAL-KDARGKL----EGLEDALQKAKQDMARLLK
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLN-G
EG--VG-PV-------N-ISVVQSTV----------------------------------
------------SSGYGSAG-------------------GA--S----------------
----------------------------------------SSLGLGGG-S----SYSYS-
-------------------------SS--------------HGLG--------------G
GFSAG---SGRAIG--GGLS--SSGGLSSSTIKYT----TTS------------------
------------------------------------------------------------
------------SSKKSYRQ----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTQKSYK--VST--SGPRAFSSRSYTSGPG-----ARI-SSSSF-------------
-------------------------------------------------------SRVGS
S----------------------------------SFRGG------------LGGGY---
------------------------------------------------------------
-------------------GGAS--------------------VTVNQSLLSPL----NL
EVDPNIQA--VRTQEKEQIKTLNNKFASF------IDK--VR------------------
----FLKQQNK-MLETKWSLLQQ-QKT-----AQSNM--DNMFE-SYINNLRRQLETLGQ
EKLKLEAELGN-MQGLVEDFKNK-YEDEINKRTE---MENEFVLIK--K---DVDEAYMN
KVELESRLEGLTDEINFLRQLYEE-----EIRELQSQISDT----SVVLSMDNSRSLDMD
SIIA-EVKAQYEEIAN-RSRAEAESMYQIK--YEEPQSLAGKHGDDLRRTKTEISEMN--
RNISRLQAE-I--EGLKG------------------------------------------
-----Q-RA--SLEAAIADAER-RGELAI-KDANAKL----SELEAALQRAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEES---------------------------RLE-S
---GM---Q--------NMSIHTKTTSG--------------------------------
---------------YAG---------------------GLRS-----------------
---AYG------------------------------GLTRPGLSYGLC------------
--------------------------------SS---------FGSGA---------GSS
SFSRT-------------------SSSRAVVVKKI------ETRDGKLVSESSDVLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSM
R--VT-QTYK--VS--TSGPRDFSSLSYTSGPG-----SHV-SSSSF-------------
-------------------------------------------------------SRVDS
S----------------------S-----------SFQGS------------LGL-----
--------------GGYG------------------------------------------
-----------------GAAA----------------------VLVNQSLLNCL----DL
EVDPNIQA--VRLQEKEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-MLATKWSLLQQ-QQT-----SQSNM--DNMFE-SYNSHLRQQLDTLGQ
EKLKLEAELGN-KQGLVEDFKNK-YEDEINKRRE---IENKFVLIK--K---DVDEAYMN
KVELESRLE-LTDEINFLRQQYEE-----EICELQSQISDT----SVVLSMDNSRSLDLD
GIIT-EVKAQYEKTAN-LSHAEADSMYQIK--YEELQTLAGKHRDDLHCMKSEISDKN--
HSISRLQGK-I--EALKG------------------------------------------
-----Q-RA--SLEAAIADAKQ-RGELAI-NDTNAKL----AQLEGALQKAKQDMAQQLH
EYQKLMNVKLVVDIE-TTYHKLLEGEEN---------------------------RLE-A
---GM---Q--------NMSIQMKTTSG--------------------------------
---------------YSG---------------------MVSS-----------------
---PYG------------------------------GLPIPGFGSLQS------------
-----------------------------------------------------------P
GFTPT---------------------KSAVVVKKI------KTCDRKLVSQTSDVLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTQKSYK--LS--TSGPRAFSSHSYSSGPG-----ACI-SSLSF-------------
-------------------------------------------------------SQVGS
-----------------------S-----------SFRGG------------LGG-----
---------------GYG------------------------------------------
-----------------GASG----------MGGI------TAVMVNQNLLSPL----VL
EVDPNIQA--VCT QEKEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-MPETKWSLLQQ-QKT-----ARSNM--DNKFE-SYINNLRRQLETLGQ
EKLKLEAELGN-IQGLVEAFKNK-YEDEINKRTK---MENEFVLTK--K---DVDEAYMN
KVELESRLEGLTEEISFLRQLYEE-----EIRELQSQISDT----SVVLSMDNSHSLDMD
SVIA-EVKAQYEETAN-RSQA----EA------ESMYQIKNEELDDLWRTKTEISEIN--
RNISRLQAE-I--EGPKG------------------------------------------
-----Q-RA--SLEAAIADAQQ-RGELTI-KYANAKL----SELEAALQRAKRDMLRQLR
EYQELRNVKLVLDVEIATYRKLLEGEES---------------------------RLE-S
---GM---Q--------NMSIHTKTTSG--------------------------------
---------------YAG---------------------GLSS-----------------
---AFG------------------------------GLTSPSLSCGLG------------
---------------------------------S--------SFGSGA---------GSS
SFSRT-------------------SSSRAVVVKKI------ETRDRKLVSESSDSCPSE-
--QLRQP--LP----ACPFCAAPEFG-RRPLCRVALG----TGDPPEAQPWPSAHLR-GS
LLP------------------GDPAC----------PCLQLQNNSIAFF----FFFLVQN
KTSASSFKKKKKKGEGEFI-LIGVFYLINQYMM---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
----------------------------MNGVSWSQGL-QEG------SPASTPASTMSI
R--VTQKSYR--VS--TTGPGAFSSRSFTSGPS-----ARS-SSSSF-------------
--------------------------------------------------------SR-V
S---------------------SA-----------GFRGG------------LGAGL---
--------------EL--------------------------------------------
-------------------LTS-----------------------RNPP-----------
---ALA--------------TQ------SAGITSVSPH--VR------------------
----FLEQQNK-MLETKWSLLQQ-QKT-----ARSNM--DNMFE-SYINNLRRQLETLGQ
EKLKL--ELGN-MQGLVEDFKNK-YEEEINKRTE---MENEFVLIK--K---DVDEAYMN
KVELESRLEGLTDEINFLRQLYEE-----EIRELQSQISDT----SVVLSMDNSRSLDMD
SIIA-EVKAQYEEIAN-RSRAEAESVYQIK--YEELQKLAGKHGDDLRRTKTEISEMN--
RNISRLQAE-I--EGLKG------------------------------------------
-----Q-RA--SLEAAIIDAEH-RGEQAL-KDARAKQ----QQLEEALQKAKQDMARQLR
DYQELMNVKLALDIEIATYRKLLEGEES---------------------------RLE-S
---GM---Q--------NMSIHTKTTSG--------------------------------
---------------YAG---------------------GLSS-----------------
---AYG------------------------------GLTSPGLSYGLG------------
---------------------------------S--------SFGSGA---------GS-
TFSRT-------------------SSTKAVVVKKI------ETRDGRLVSESSDVLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MISRQQCVR-----G-GSQGFSCVSAV-VGG----GKRP-AFSSVS---TSGGT----
-----------------------------------------GRCS-SGGFGSRSLYNLGG
R-KSIAISMAGSRQ-GA-GFGAAGG-----------FG----------------------
--------------------------------------VGNFG-----------------
---SGFGG----SFG--GRGGPGFP-VC--PAGGI------QEVTINQSLLTPL----HV
EIDPEIQK--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQQQTTTT----SSKNL--EPLFE-AYISVLRKQLDTLAN
DKGRLQSELKS-TQDSVEDFKTK-YEDEISKRTT---AENDFVVLK--K---DVDIAYMT
KVELEAKVDALNDEINFLRVLFAA-----ELCQMPTHVSDT----SVVLSMDNNRNLDLD
SIIA-EVRAQYEEIAQ-KSKAEAEALYQTK--VQQLQISVDQHGDSLKNTKSEISELN--
RMIQRLRAE-I--ENVKK------------------------------------------
-----Q-CQ--TLQASVADAEQ-RGELAL-KDAYSKR----TELEAALQKAKEELARMLR
DYQELMSVKLALDVEIATYRKLLEGEE--------------------------C-RMS-G
ECQSA---L--------SISVVGGGASAGT------------------------------
---------------IG-GG---LGS----C---SGFG--LGS-----------------
---------------------------------GFGSG--SGSGFGF--G-GG-------
----VCGSSGSKIISTSTMIKRS--HR---------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------MGGI------AAITVNQSLLSRL----NL
EVDPNIQA--VRTQEKE-AKTLSNKVASF------MDK--VR------------------
----FLEQLNK-MLETKWNLLQQ-QTT-----AGSNM--DRMFE-SYINNLQPQLDTLGQ
EKLKLEAELGN-MQGLVEDFKSK-YEEEIDK-TE---MENESVLIK--K---DVGS-YTN
QVELESRLDRLTDEIKFLRQQYEE-----EIRELP-QISDT----SVVLSVDNSRSLDMD
GIIA-EVCAQSEEIAN-HSRAEAESVDQTR--YEELQVQAGKYRDDLRRTKTEISDMN--
RNISQAEAE-N--VDQTG------------------------------------------
-----A-G-----GMGGVTAIT-CGELAL-KDANAKL----AQLEAAPRQAKQ---DQLR
EYQDLMNVKLALDVEIATYLKLLEREES---------------------------RLE-S
---RM---Q--------NMSVHTMTTSG--------------------------------
---------------YSG---------------------GLSS-----------------
---AYGRG----------------------------GLTSPGLSYGLS--------SF--
--------------------------------QT--------RFGSGG---------GSS
SFSRT--------------------SSRAVVVKKI------ET-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTQKSYK--VST--SGPRAFSSRSYTSGPG-----GRI-SSSAF-------------
-------------------------------------------------------SRVGS
S--------------------SSS-----------SFRPG------------LGAGF---
--------------GP---F----------------------------------------
---------------GGF--GVG-------GAGGI------TSVTVNQSLLSPL----KL
EVDPNIQA--VRTQEKEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQQ-QKT-----SRSNM--DSMFE-SYINNLRRQLETLGQ
EKLKLEAELGN-MQGLVEDFKNK-YEDEINKRTE---MENEFVLIK--K---DVDEAYMN
KVELESRLEGLTDEINFLRQLYEE-----EIRELQAQISDT----SVVLSMDNSRSLDMD
GIIA-EVKAQYEEIAN-RSRAEAESMYQIK--MRELQTLAGKHGDDLRRTKTEI-EMN--
RNISRIQAE-I--EALKG------------------------------------------
-----P-RA--SLEAAIADAEQ-RGELAI-KDAQNKL----AELEAALQRAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEES---------------------------RLE-S
---GM---Q--------NMSIHTKTTSG--------------------------------
---------------YSG---------------------VLGS-----------------
---AYG------------------------------GLTSPGLNYGVSSF-------Q--
--------------------------------SS---------FGSGG---------GPG
FSTRT-------------------GSTKTVVVKKI------ETRDGKLVSESSDVLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------VSI
R--VTQKSYK--VS--TSGPLAFSSHSYTSEPG-----ACI-SSLS--------------
-------------------------------------------------------SRVGS
-----------------------S-----------SFRGG------------LGR-----
---------------GYG------------------------------------------
-----------------GASG----------MGGI------TTVTVNQSLLSPL----NL
EVDLSIQA--VHT QKKEQIKTLNNKFASF------IDT----------------------
--------QNK-MLETKWSLLQQ-QKT-----AQSNM--DNMFQ-SYINNLRRQLETVDQ
EKLKLEVELGN-MQGLVENFKNK-YEDETNKCRE---MENEFVLIK--K---DVDEAYVN
KVELESRLEGLTDEINFLRQLYEE-----DIPELQSQISDT----SVVLSMDNSSSLDMD
SIIT-EVKAQYEITNR--------SRYQIE--YEELQ-----TLDDLRHTKAEISEMN--
RNISQLQAE-I--ESLKG------------------------------------------
-----Q-RA--SLEAAIADAEQ-RGELAI-KDVNA-----------ALQRAKQDMVRQLR
EYQELMNAKLALDIEIATYRKLLEGEES---------------------------RLE-S
---GM---R--------NMSIHTKTTSS--------------------------------
---------------YAG---------------------GPSS-----------------
---AYG------------------------------SLTSPGLSYDLG------------
---------------------------------S--------SFGSGT---------GSS
SFSCT-------------------SFTRAVVVKKI------ETCDGKLVSKSSEVLSK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQSSVS--FR-SGGSRSFSTASAITPS-----VSRT-SFSSV---SRSGG----G
GGGRVS--------------------------FG-------VA-GGAGGFGSRSLYNLGG
S-KRISISAS----GG--GFRNR-------------FGAGAGS----G--FGFGGGA-G-
--------------SGFGFG--SGAGGG------------------------GF----GL
G--GGAGFG-G-GYGGAGFP------VC--PPGGI------QEVTINQSLLTPL----NL
QIDPTIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWNLLQEQGTR----TVKQSL--DPLFE-QYINNLRRQLDSILG
ERTRLDSELRN-MQDLVEDFKNK-YEDEINKRTT---AENEFVMLK--K---DVDAAYMS
KVELEARVDALMDEINFMKLFFDA-----ELSQMQTHVSDT----SVVLSMDNNRNLDLD
SIIA-DVKAQYEDIAN-RSRTEAESWYQTK--YEELQQTAGRHGDDLRNTKHEISEMN--
RMIQRLRAE-I--DNVKK------------------------------------------
-----Q-CA--NLQAAIADAEQ-RGELAL-KDARNKL----TELEEALQKAKQDMARLLR
EYQELMNTKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VG-PV-------N-ISVVTNSL----------------------------------
------------SSEWDG----------------SGFGG--GLSRGLGGG----L-----
-----G----------------------------------------GGGG----SSYYS-
-----------------------SSSG-----GVGLG--SRLSARG-------------S
GFSSS---SGRGIGIGIGS----AGS-SGSSVKFV----STTS-S---------------
------------------------------------------------------------
-------------SRRTFKS----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSW
QSSVT---------FQTSSRRGFSTAS--TPA-----ASNS-RFCSISVACSSGGNG---
-----E-----------------------------L----GRISNTRAGCGSRSLYNLGA
T-KRASVSGCSSSF-R-SGFGSRAG-----------------------------------
--------------SGFGFA----SGISNRFGYG--------------------------
-----------GGVGG-GFGTPGFP-IY--PTGGI------QEVTVNPSLLTPL----NT
QIDPTTQR--VRKEEREQIK-MNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQEKGSRT----VRKNL--EPLFD-AYTSELRRQLDSITS
ERCRLEAELRN-MQDTVEDFKVR-YEDEINKRAA---AENEFVALK--K---DVDGAYMN
KVELETKVNSLTDEINFFQMFYAA-----XXXXXXXXXXXX----XXXXXXXXXXXXXXX
XXXX-XXXXXXXXXXX-XXXXXXXXXXXXX--YEELQATAGRHGDDLRNTKHEISEMN--
RMIQRLRAE-I--DSVKK------------------------------------------
-----Q-CA--SLQTAIVDAEQ-RGELAL-KDARAKL----VDLEEALQKARQDLARLLH
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG-VSP--V--------NISVVT----NTV------------------------------
------------SSGYSS----GSGS----GSGT-------------------GSG----
---SFG--------------------------------------LSGGSG----YSFTTS
IGHSLG-----------------------------------------------------A
GLSGS--SN-RGLSSGS-------------GVKFV----STT------------------
------------------------------------------------------------
----------SSS-RKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MIARQPSVR-----G-VSRGFSSGSAI-AAG----VRRV-AFSSAS---MSGGA----
-----------------------------------------GRCS-SGGFGSRSLYNLGG
H-KSISMSVAGSCQ-GG-GYGGAGG-----------FGVGGFG-----------------
-------------AG-FG----------------AGGFG---------------------
---GGFGG----SFN--GRGGPGFP-VC--PAGGI------QEVTINQSLLTPL----QV
EIDPEIQK--VRTA EREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQQQTTST----SPRNL--DPFFE-TYINALRKHLDSLIN
DKGRLQSELKL-MQDSVEDFKAK-YEDEINKRTA---AENDFVVLK--K---DVDAAYMI
KVDLEAKVDSLKDEINFLRVLYEA-----ELSQMQTHVSDT----SVVLSMDNNRNLDLD
GIIA-EVRAQYEEIAQ-RSKAEVESWYQIK--VQQLQNSADQQGDSLKSTKNEISELN--
RMIQRLRAE-I--ENIKK------------------------------------------
-----Q-CQ--TLQASVADAEQ-RGEVAL-KDAYSKR----TELETALQKAKEDLARLLR
DYQALMNVKLALDVEIATYRKLLEGEE--------------------------C-RMS-G
ECQSA---V--------SISVVGGSASIG-------------------------------
-----------------------GS---------------------------AGLGL---
---GLGS------------------------GFGSGSG--SGSGFGF--G-GG-------
----IYGSSGTKITSATTVT--KRSQR---------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSL
H-------------F---GSQVFSSRSAAFPGR----GAPV-RLSSV----RPGG-----
----------------------------------------------FGSS--SSLYGLG-
------------AS-RPRVAA--RS-----------------------------------
---------------SYG------------------------------------------
----------------A-------P-----VGTGI------SAVTINQSLLTPL----QV
DIDPSIQQ--VRQ EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-LLETKWTLLQEQKSA-----KSNRL--PGIFE-AQIAGLRKQLEALQL
DGGRLEVELRN-MQDIVEDFKNK-YEDEINRRTA---AENEFVVLK--K---DVDVAYMN
KVELEAKVDGLNDEINFLRTLYEQ-----ELKELQSEVSDM----SVVLSMDNNRSLDLE
SIIA-EVKAQYEEIAN-RSRAEAEACYQTK--FETLQAQAGKHGDDLRNTRNEIADMN--
RAIQRLQAE-I--ENIKN------------------------------------------
-----Q-RA--KLEAAIADAEQ-RGELAV-KDARAKQ----EDLEAALQKAKQDMTRQLR
EYQELMNIKLALDIEIATYRKLLEGEE--------------------------S-RLT-G
DGVGA---V--------NISV---------------------------------------
----VSS----------TGG----------------SGSRLTFGG-----TMGNNALRFS
SG-----GGPGT------------------------------------------------
--------LKAYSMRTTSATSRSPRN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------M--
----NRQVCRT--S--GGGSQGFSGRSAVVSG------SSR-M-SC---VARSGGA-G--
-----GG-------------------------VSGFR----SG---AGGFGSRSLYNLGG
N-KSISISVAGGGS-RAGGFGGGRS------S--CGFGGSCGSGFGGGYGG----GFGGG
------FGGGFGGAGGFG--------GAGGFGGA-----GGLGGAGGFGGPGGF------
GGPGGFGVPG--GFGG---P------GG--FPGGI------QEVTVNQSLLQPL----NV
EIDPQIGQ--VKA QEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQQQGTNSI--TGTNNL--EPLFE-NRINYLRSYLESILG
ERGRLDSELRN-MQDLVEDFKKK-YEDEINKRTA---AENEFVTLK--K---DVDAAYMN
KVELQAKVDDLMEEINFLRTLYDA-----ELSQMQSHVSDT----SVVLSMDNNRCLDLD
SIIA-DVRAQYEDIAQ-RSKAEAEALYQTK--LGELQTTAGRHGDDLRSTKSEIVELN--
RMIQRLRAE-I--ENIKK------------------------------------------
-----Q-NA--NLQTAIAEAEQ-RGEMAL-KDANTKL----QELQAALQQAKDDLARLLR
DYQELMNVKLALDVEIATYRKLLEGEE--------------------------Y-SPI-S
PHPLT---Q--------ATSRAR-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MIARQQCVR-----G-GPRGFSCGSAIVGSG----KRG--AFSSVS---VSGGA----
-----------------------------------------GRCS-SGGFGSRSLYNLGG
N-KSISLSVAGSRQ-GA-CFGGAGG-----------FGT---------------------
---------------------------------------GGFG-----------------
---GGFGG----SFS--GKGGPGFP-VC--PAGGI------QEVTINQSLLTPL----HV
EIDPEIQK--VRT EEREQIKLLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWKLLQQQTTST----SSKNL--EPLFE-TYLSVLRKQLDTLVN
DKGRLQSELKT-MQDSVEDFKTK-YEEEINKRTA---AENDFVVLK--K---DVDAAYMN
KVELEAKVDSLNDEINFLKVLYDA-----ELSQMQTHVSDM----SVVLSMDNNRNLDLD
SIIA-EVRAQYEEIAQ-RSKAEAEALYQTK--VQQLQISVDQHGDNLKNTKSEIAELN--
RMIQRLRAE-I--ENIKK------------------------------------------
-----Q-CQ--TLQASVADAEQ-RGENAL-KDAHSKR----IELETALQQAKEELARMLR
EYQELMSVKLALDIEIATYRKLLEGEE--------------------------C-RMS-G
ECQSA---V--------SISVVGGSTSTGG------------------------------
---------------ISG-G---LGS-----------------------------GS---
---GFGL------------------------SSGFGSG--SGSGFGF--G-GS-------
----VSGSSSSKIISTTTLNKRR-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MIARQQCVR-----G-GSRGFSCGSAVVGGV----KRR--AFSSAS---VSGGA----
-----------------------------------------GRCS-SGGFGSRSLYNLGG
N-KSISMSVAGSRQ-GA-CFGGA-------------------------------------
-----------------GA----------------GFGAAGFG-----------------
---GGFGG----SFS--GKGGPGFP-VC--PAGGI------QEVTINQSLLTPL----HV
EIDPEIQK--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQQQTTTT----SSKNL--EPLFE-TYLSVLRKQLDTLVN
DKGRLQSELKT-MQDSVEDFKTK-YEEEIHKRTA---AENDFVVLK--K---DVDAAYMN
KVELEAKVDSLNDEINFLKVLYDA-----ELSQMQTHVSDT----SVVLSMDNNRNLDLD
SIIA-EVRAQYEEIAQ-RSKAEAEALYQTK--VQQLQVSVDQHGDNLKNTKSEIAELN--
RVIQRLRAE-I--ENIKK------------------------------------------
-----Q-CQ--TLQTSVADAEQ-RGENAL-KDAHSKR----IELEAALQQAKEELARMLR
EYQELMSVKLALDIEIATYRKLLESEE--------------------------C-RMS-G
ECPSA---V--------SISVVSSSTSTGG------------------------------
---------------IGG-G---FGS-----------------------------GS---
---GFGL------------------------SSGFGSG--SGSGFGF--G-GS-------
----VSGSSSSKIISTTTLNKRSSR-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MNRQVCKK--SF-SGGSQGFSGRSAVVS-G-----SSR-M-SC---VARSRGA-G--
-----GG-------------------------ACGFR----SGA---GGFGSRSLYNLGG
N-KSISISVAAGGS-RAGGFVGGQS------SCG--FAGGYGGG----FGGSYGGGFGGG
--R--GIGSGFG-------------------------------GAGGFGGAGGFGGPGVF
GGLGSFGSPG--GFV----P------AG--FSGGI------QEVTVNQSLLQPL----NV
EIDPQIGQ--VKA QEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWELLQQQTTG----SGPSSL--EPCFE-SYINFLRKQLDSLLA
ERGNLEGELKS-MQDLVEDFKKK-YEDEINKRTA---AENEFVGLK--K---DVDAAFMN
KVELQAKVDSLTDEVSFLRTLYEM-----ELSQMQSHVSDT----SVVLSMDNNRCLDLD
NIIA-EVRAQYEEIAQ-RSKAEAEALYQTK--LGELQTTAGRHGDDLKNTKSEIMELN--
RMIQRLRAE-I--ENVKK------------------------------------------
-----Q-NA--NLQTAISEAEQ-RGEMAL-KDANAKL----QDLQAALQKAKDDLARLLR
DYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RMS-G
ECQSA---V--------CISVVSNVTST--------------------------------
---------SGSSGSGRGVFGGVSG------S--GGYRGGGSSSS---------------
--------------------SSA-YGAVSG---------GSSSSYGGVSS-GS---TG--
GR-GSSGGYQ--------------------SSSS------GSRLGGAGSMS---MSHSGM
GSSSG--SV-QTSGGSGYKS----GGGGSTSIRFS----QTT------------------
------------------------------------------------------------
----------SSS-QHNSTK----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSV
R-------------F---SSQTFSSRSAAFPRK----GGQG-LVSSV----TTRG-----
----------------------------------------SS-TSHMGGFGSSSLYGLG-
------------TA-RPRVAVGVHS-----------------------------------
---------------VYG------------------------------------------
----------------GSSGGVCGA-----RGAGI------HEVTINQSLLAPL----NL
EIDPQIQQ--VRKEEREQIKTLNNRFASF------IDK--VR------------------
----FLEQQNK-MLETKWKLLQEQKSP-----KGSCI--PSMFE-TQIANLRRQLDGLLT
DRSRLEGELKN-MQDVVEDFKNK-YEDEINKRTA---AENEFVILK--K---DVDTAFMN
KVELEAKVDALTDEINFLKALYEM-----ELNELQAQISDT----SVVLSMDNSRNLDLD
GIIA-EVKAQYEDIAN-RSRAEAESWYQAK--FEYLQAQAGKHGDDLRSTRNEIAEMN--
RAIQRLQAE-I--DNIKN------------------------------------------
-----Q-RA--KLEASIAEAEE-RGELAL-KDARAKQ----EELEAALQRSKQEMARQLR
EYQDLLNVKLALDIEIATYRKLLEGEE--------------------------S-RLS-G
DGVGS---V--------SISV---------------------------------------
----VNSV-G--------GC----------------LGSGVSFGG-----TMGTNSLGFS
SG-----AGSGN------------------------------------------------
--------VKSYSIKTTSSTTRKSFRN---------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSSKSTMR--SH-SSSHRGFSAGSARVPG-----VSRS-GFSSVS-VSRSRGSGGLG
A-------------------------------VC-----------GGGRFGSRSLYNLGG
S-KRISIGGG----SC--AVSGG-------------YGS--RV----GGGFGFGGGA-G-
--------------SGFSFG--GG--A------GG-----------------GF----GL
G--GG-AGFGG-GFGGAGFP------VC--PPGGI------QEVTINQNLLTPL----NL
QIDPTIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVRQNL--EPLFE-QYISTLRRQLDSILG
DKGRLDSELRG-MQDLVEDFKNK-YEDEINKRTA---AENEFVTLK--K---DVDAAYMN
KVELQARVDSLTDEINFLRAFYDA-----ELSQMQTHISDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEEIAH-KSRAEAESWYQTK--YEELQVTVGRHGDDLRNTKQEIAEMN--
RMIQRLRSE-I--DHVKK------------------------------------------
-----Q-CA--NMQAATADTEQ-RGEMAL-KNARSKQ----GELEDALPKAKQAMAQQLM
EYRELLNVKLVLDVEIAAYREMLEGEE--------------------------K-RAH-G
VF--SC-PC-------P-L-PTTSTV----------------------------------
------------SGGYGGAGG-------------------------V-------------
---------------------------------------GSGVALGGGSG----YS----
-----------------------YSGG--------------HSLG--------------G
GFSSS---SGRGLG--GGLS--SVGGS-SSSIKYT----TTTT-S---------------
------------------------------------------------------------
------------SSKKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQACKK--SF-G---QGFSGHSAVVSG------SSR-R-SC---VARTGAA-S--
-----GG-------------------------ACGFR----SR---AGSFGSQSLYNLGG
S-RSISISVVAGGS-QTGGLGGGHG------SSGSGY----GGGFGGSRG----------
------IGG-------------------------------------------GFGGASGF
GGAS--------GFGR---PGGFGP-SG--CHGGI------QEVTINQSLLQPL----NV
EIDPQIGQ--VKA QEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-ILETKWELLRQ-TTGTG--SGPQSL--EPFFE-SYISCLCKQLDSLLG
EKGSLDGELRS-MQDLVEDFKKR-YEEEVNRRTA---AENEFVGVK--K---DVDGAYLS
KVELQAKVNSLTDEIDFLRTLYDM-----ELSQMQSHVSDT----SVVLSMDNNRFLDLD
SIIS-EVKAQYEDIAQ-RSKAEAEALYQTK--LGELQTTAGRHGDDLRNTKSEIMDLN--
RMIQRLQAE-I--ENVKK------------------------------------------
-----Q-NT--NLQTSIAEAEQ-RGEVAL-KDADAKF----QDLQAALQKAKDDLARLLR
DYQTLMNVKLALDVEIATYLKLLEGEE--------------------------S-RMS-G
ECQSA---V--------SISVVSNVTS---------------------------------
--------TSSS----SGGFRGVSSS----SS--G-SRGGS-------------------
----------------SSGGFR------------------------GASS--SSYGGD--
SS---------G------------SNSRGSREST------GSRLGSEGSV--SV-SQRGM
GFNTG--GT-QASAGGSYKS----SRGGSSSVHFS----QTT------------------
------------------------------------------------------------
----------SSS-QQRSK-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
MA--STSTTIR--SH-SSSRRGFSAGSARLPG-----VSRT-GFSSVS-VSRSRGSGGLG
G-------------------------------AC-----------VGAGFGSRSLYGLGG
S-KRISIGGG----SC--AISGG-------------YGS--RA----GGSYGFGG-A-G-
--------------SGFGFG--GG--A------GI-----------------GF----GL
G--GG-AGLAG-GFGGPGFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPTIQR--VRAEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWTLLQEQGTK----TVRQNL--EPLFE-QYLNNLRRQLDSIVG
ERGRLDSELRG-MQDLVEDFKNK-YEDEINKRTA---AENEFVTFK--K---DVDAAYMN
KVELQAKADTLTDEINFLRALYDA-----ELSQMQTHISDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEEIAQ-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEIAEIN--
RMIQRLRSE-I--DHVKK------------------------------------------
-----Q-CA--NLQAAIADAEQ-RGEMAL-KDAKNKL----EGLEDALQKAKQDLARLLK
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLN-G
EG--VG-PV-------N-ISVVQSTV----------------------------------
------------SSGYGGASG-------------------------V-------------
---------------------------------------GSGLGLGGGSS----YS----
-----------------------YGSG--------------LGVG--------------G
GFSSS---SGRAIG--GGLS--SVGGG-SSTIKYT----TTSS-----------------
------------------------------------------------------------
------------SSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQSSVS--FR-SGGSRSFSAASAITPS-----VSRT-SFTSV---SRSGG--GGG
GFGRVS--------------------------LG-------GACGA-GGFGSRSLYNLGG
S-KRISISAS----GG--NFRNR-------------FGAG--A----GGGYGFGGGA-G-
--------------SGFGFG--GGAG--------G-----------------GF----GL
G--GGA-GFGG-GFGGAGFP------VC--PPGGI------QEVTINQSLLTPL----NL
QIDPTIQR--VKT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVRQNL--EPLFE-QYINNLRRQLDSILG
ERGRLDSELRN-MQDLVEDFKNK-YEDEINKRTT---AENEFVMLK--K---DVDAAYMN
KVELEAKVDALMDEINFMKMFFDA-----ELSQMQTHVSDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEEIAN-RSRTEAETWYQTK--YEELQQTAGRHGDDLRNTKHEISEMN--
RMIQRLRSE-I--DNVKK------------------------------------------
-----Q-CA--NLQNAIADAEQ-RGELAL-KDARNKL----AELEDALQKAKQDMARLLR
EYQELMNTKLSLDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VG-PV-------N-ISVVTSSV----------------------------------
------------SSGYGSGG-G--------------YGG--GFGGGLGGG----L-----
-----GGS----------------------------------LG-GGGGG----SYYSS-
-----------------------SS--------GGMG--GGLSVGG-------------S
GFSAG---SGR-VGVGFGS---GG-G-SSSSVKFV----STTS-S---------------
------------------------------------------------------------
-------------SRKSFKS----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
----------------------------------------------------------MR
-SSVSRQTYAT--------KGGFSSNSASGG---AGSRTHT-SFSSVT-MSRSGGSGGG-
--------------------------V--------------HYGPRIGGFGSRSLYNLGG
S-KSISVSVA---SSG-RGL----------------------------------------
--------------GGFGHS------------------SGAYG-----------------
-------GLG-------AGRQTFGP-VC--PPGGI------QEVTINQSLLTPL----NV
EIDPEIQR--VRT QEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNQ-VLETKWALLQEQGQNTG--VTKNNL--EPIFE-AFLSNLRRVLDSKLG
ERGRLDTELRN-VQDGLEDFKNK-YEDEINKRTA---LENEFVVLK--K---DVDAAYMT
KMDLQGRVDSLLQEIDFLQCLYEM-----ERSQVQTHVSDT----NVILSMDNNRNLDLD
SIIT-EVKAQYELIAQ-RSRAEAEAWYQTK--YEELQVTAGKHGDNLRDTKNEIAELT--
RTIQRLQSE-V--DAAKK------------------------------------------
-----Q-CQ--QLQAAIAEAEE-CGDLAL-KDAKKKL----GDLDTALHHAKEDLARLLR
DYQALMNVKLALDVEIATYRKLLESEE--------------------------S-RMS-G
ECPSA---V--------SISVTGNSTTVCG------------------------------
-----------------G--------------------GGISLGGG---VG--ASKCGFS
TN----------------------------------------AGYGT----------V--
KGGPVSG--GTSILRKT--TTVKTSRRKY-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQSSVS--FR-SGGSRSFSTASAITPS-----VSRT-SFTSV---SRSGG--GGG
GFGRVS--------------------------LG-------GACGV-GGYGSRSLYNLGG
S-KRISISTS----GG--SFRNR-------------FGAG--A----GGGYGFGGGA-G-
--------------SGFGFG--GGAG--------G-----------------GF----GL
G--GGA-GFGG-GFGGPGFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPSIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVRQNL--EPLFE-QYINNLRRQLDSIVG
ERGRLDSELRN-MQDLVEDFKNK-YEDEINKRTT---AENEFVMLK--K---DVDAAYMN
KVELEARVDALMDEINFMKMFFDA-----ELSQMQTHVSDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEEIAN-RSRTEAESWYQTK--YEELQQTAGRHGDDLRNTKHEISEMN--
RMIQRLRAE-I--DNVKK------------------------------------------
-----Q-CA--NLQNAIADAEQ-RGELAL-KDARHKL----AELEEALQKAKQDMARLLR
EYQELMNTKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VG-PV-------N-ISVVTSSV----------------------------------
------------SSGYGGGS-G--------------YGG--GLGGGLGGG----L-----
-----GGGLGGGL--------------------------GGGLG-GGSSG----SYYSS-
------------------------SSG-----GVGLG--SGLSVGG-------------S
GFSAS---SGRGLGVGFGS---GG-G-SSSSVKFV----STTS-S---------------
------------------------------------------------------------
-------------SRKSFKS----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQSSVS--FR-SGGSRSFSTASAITPS-----VSRT-SFSSV---SRSGG----G
GGGRVS--------------------------FG-------VA-GGAGGFGSRSLYNLGG
S-KRISISAS----GG--GFRNR-------------FGAGAGS----G--FGFGGGA-G-
--------------SGFGFG--SGAGGG------------------------GF----GL
G--GGAGFG-G-GYGGAGFP------VC--PPGGI------QEVTINQSLLTPL----NL
QIDPTIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWNLLQEQGTR----TVKQSL--DPLFE-QYINNLRRQLDSILG
ERTRLDSELRN-MQDLVEDFKNK-YEDEINKRTT---AENEFVMLK--K---DVDAAYMS
KVELEARVDALMDEINFMKLFFDA-----ELSQMQTHVSDT----SVVLSMDNNRNLDLD
SIIA-DVKAQYEDIAN-RSRTEAESWYQTK--YEELQQTAGRHGDDLRNTKHEISEMN--
RMIQRLRAE-I--DNVKK------------------------------------------
-----Q-CA--NLQAAIADAEQ-RGELAL-KDARNKL----TELEEALQKAKQDMARLLR
EYQELMNTKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VG-PV-------N-ISVVTNSL----------------------------------
------------SSEWDG----------------SGFGG--GLSRGLGGG----L-----
-----G----------------------------------------GGGG----SSYYS-
-----------------------SSSG-----GVGLG--SRLSAGG-------------S
GFSSS---SGRGIGVGIGS----AGS-SGSSVKFV----STTS-S---------------
------------------------------------------------------------
-------------SRRTFKS----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
----------------------------------------------------------MR
-SSVSRQTYST--------KGGFSSNSASGG---AGAGTRT-SFSSVT-VSRSSGSGGR-
--------------------------A--------------RCGPSTGGFGSRSLYNLGG
H-KSISVSVAGGASVG-QAL----------------------------------------
--------------GGFGFG------------------SRAFT-----------------
-------GLG-------AGRQTFGP-AC--PPGGI------QEVTVNQSLLTPL----HV
EIDPEIQR--VRTQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQGQNLG--GTRNNL--EPLFE-AYLGNIRSVLDRLQG
ERGRLDSELRN-VQDLVEDFKNK-YEDEINKRTA---AENEFVVLK--K---DVDAAYMG
QMDLQGKMGTLTQEIDFLQQLYEM-----ELSQVQTHVSDT----NVVLSMDNNRNLDLD
SIIA-EVKAQYELIAQ-RSRAEAEAWYQTK--YEELQVTAGKHGDNLRDTKNEIAELT--
RTIQRLQGE-V--DAAKK------------------------------------------
-----Q-CQ--QLQTAIADAEQ-RGEMAL-KDAQKKL----GDLDVALHQAREDLARLLK
EYQELMNVKLALDVEIATYRKLLESEE--------------------------S-RMS-G
ECPSA---V--------SISVTGNSTTVRG------------------------------
-----------------GG--------------AAGFGGGISLGGS---GG--ATKGGFS
TN----------------------------------------VGYST----------I--
KGGPVSG--GTSILRKT--TTVKTSSRRY-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MIARQQGVR-----G-GSRGFSCGSAIVGGG----KRA--AFSSLS---VSGGA----
-----------------------------------------GRCS-SGGFGSRSLYNLGG
S-KSICMSVAGSRQ-GA-GFGSAGG-----------FGA---------------------
---------------------------------------GGFG-----------------
---SGYGG----SFN--GRGGPGFP-VC--PAGGI------QEVTINQSLLTPL----HV
EIDPEIQK--VRTEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQQQTTTT----SVKNL--EPLFE-VYLSALRKQLDSLFN
DKGRLQSELKT-MQDSVEDFKTK-YEDEINKRTA---AENDFVVLK--K---DVDAAYMT
KVELEAKVDGLNDEISFLKAFYDA-----ELSQMQTHVSDT----SVVLSMDNNRNLDLD
SIIA-EVRAQYEEIAQ-RSKAEAEALYQTK--VQQLQTSVDLHGDSLKNTKSEIAELN--
RMIQRLRAE-I--ENVKK------------------------------------------
-----Q-CQ--TLQASVADAEQ-RGEVAL-KDAYNKR----TELEGALQKAKEELAKMLR
EYQELMNVKLALDIEIATYRKLLEGEE--------------------------F-RMS-G
ECQSA---V--------SISVVGSGVSAGG------------------------------
---------------IGG-G---LGS-----------------------------SS---
---GFGL------------------------GSGFGSG--SGSGFGF--G-GG-------
----VSGSSSGKIITTKRSQR---------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSR
QFT-----CK----SGAATKGGFSGCSAVLSGGS------------SS-SFRAG------
------------------------------------------SKGLSGGFGSRSLYSLGG
V-RS--LNVASGSG-KSGGY----------------------------------------
-------------------------------GFGRGRA----------------------
------SGFAGSMFGSVALGPVCPT-VC--PPGGI------HQVTVNESLLAPL----NV
ELDPEIQK--VRA QEREQIKALNNKFASF------IDK--VR------------------
----FLEQQNQ-VLETKWELLQQLDLNN----CKNNL--EPILE-GYISNLRKQLETLSG
DRVRLDSELRN-VRDVVEDYKKR-YEEEINKRTA---AENEFVLLK--K---DVDAAYAN
KVELQAKVESMDQEIKFFRCLFEA-----EITQIQSHISDM----SVILSMDNNRNLDLD
SIID-EVRTQYEEIAL-KSKAEAEALYQTK--FQELQLAAGRHGDDLKNTKNEISELT--
RLIQRIRSE-I--ENVKK------------------------------------------
-----Q-AS--NLETAIADAEQ-RGDNAL-KDARAKL----DELEGALHQAKEELARMLR
EYQELMSLKLALDMEIATYRKLLESEE--------------------------C-RMS-G
EFPS-P--V--------SISIISSTSGGSG------------------------------
------------YGFRPSTVSGG-YV----ANSSNC-----ISGVCSVRGGEGRSRS---
SA--------------------NDYKDTLGKG----------SSLSA-------------
------------------------------------------------------------
----------------------------------P----SKK------------------
------------------------------------------------------------
----------TSR-----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQSSVS--FR-SGGSRSFSTASAITPS-----VSRT-SFTSV---SRSGGG-GGG
GFGRVS--------------------------LG-------GACGV-GGYGSRSLYNLGG
S-KRISISTS----GG--SFRNR-------------FGAGAGA----GGGYGFGGGA-G-
--------------SGFGFG--GGAG--------G-----------------GF----GL
G--GGA-GFGG-GFGGPGFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPSIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVRQNL--EPLFE-QYINNLRRQLDSIVG
ERGRLDSELRN-MQDLVEDFKNK-YEDEINKRTT---AENEFVMLK--K---DVDAAYMN
KVELEAKVDALMDEINFMKMFFDA-----ELSQMQTHVSDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEEIAN-RSRTEAESWYQTK--YEELQQTAGRHGDDLRNTKHEISEMN--
RMIQRLRAE-I--DNVKK------------------------------------------
-----Q-CA--NLQNAIADAEQ-RGELAL-KDARNKL----AELEEALQKAKQDMARLLR
EYQELMNTKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VG-PV-------N-ISVVTSSV----------------------------------
------------SSGYGSGS-G--------------YGG--GL----GGG----L-----
---------GGGL--------------------------GGSLA-GGGSG----SYYSS-
------------------------SSG-----GVGLG--GGLSVGG-------------S
GFSAS---SGRGLGVGFGS---GG-G-SSSSVKFV----STTS-S---------------
------------------------------------------------------------
-------------SRKSFKS----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
------MSIR--VS--ISGPRAFSSRFYTSGPS-----ACI-SSS---------------
---------------------------------------------------------MGS
-----------------------S-----------SFRGS------------LGG-----
---------------GYG------------------------------------------
-----------------GASG----------MGGI------TAVTVNQSLLSPL----NL
EVDPNIQ A--LHT QEKGQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQQ-QKT-----ARSNM--DNMCE-SYFSNLRRQLETRGQ
EELKLEAELGN-TQGL------------INKLTE---MENESVLIK--K---DVDEAYMN
KVELESRLEGLTNEINFLRQLSD---------------------TSVMLSKDNSRSPDMD
GIIA-EVKAQYKEIAN-RSRTEADSMYQIK--YEELQMLQDSV---SKKKKTEISKMN--
QNINWLQAE-I--EALKG------------------------------------------
-----Q-RA--SLETAIADAEQ-HGELAV-KDDNAKL----SELEA------QDMARQLR
AYQKLMNVKLALDIEIATYRKL---------------------------------RLE-S
---GM---Q--------NMSIQMKTTSS--------------------------------
---------------YAS---------------------GLSS-----------------
---AYG------------------------------GLTSPSLSYSLD------------
----------------------------------------------------------SS
SFSHI-------------------SSTRAVVVKKI------ETRNGKLVSKSFDVLPE--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTQKSYK--VST--SGPRAFSSGSYTSGPG-----ALI-SSSSF-------------
-------------------------------------------------------SRVGG
S----------------------------------SFRGG------------LGGGY---
------------------------------------------------------------
-------------------GGAS-------GMGGI------TAVTVNQSLLSPL----NL
EVDPNIQA--VRT QEKDQIKTLNNKFASF------IDK--VR------------------
----FLEQPNK-MLETRWSLLQQ-QKA-----ARSNM--DNMFE-SYINNLRRQLETLGQ
EKLKLEAELGN-MHGLVENFKNK-YEDEINKHTE---MENEFVLIK--K---DVDEAYMN
KVEMESCLEGLTDEINFLRQLYEE-----EIQELHSQIWDT----SVVLSMHNSRSLDMD
SIIA-EVKAQYKEIAN-RSRAEAESMYQIK--YEELQSLAAKHGDDLRCTKTEISEMN--
RNISRLQAE-I--EGLKG------------------------------------------
-----Q-RA--SLEAAIADAEQ-RGELAI-KDANAKL----SELEAALQRAKQDMARQLR
EYQELVNVKLALYIEIATYRKLLEGEES---------------------------RLE-S
---GM---Q--------NMSLHMKTTSG--------------------------------
---------------YAG---------------------GLSS-----------------
---AYG------------------------------GLTS------LG------------
--------------------------------SS---------FGSGA---------GSS
SFRRT-------------------SSSRAMVVKKI------KTRNGKLVSESSDLLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSSKSIRK--SQ-TITHCGFSAGSARLPG-----AGHS-GFSSIS-VSRSRGSGGLG
G-------------------------------VC-----------GGAGFGSRSLYNLGG
S-KRISIGGG----SC--AISGG-------------YGG--RV----GGGFGFGGGA-G-
--------------SGFGFG--GG--A------GA-----------------GF----GL
G--GG-AGFVG-GYGGSGFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPTIQR--VRTEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVRQNL--EPLFE-QYINNLRRQLDSILG
ERSRLDSELRG-MQDLMEDFKNK-YEEEINKRTA---AENEFVTLK--K---DVDAAYMN
KVELQAKVDSLTDEINFLRAFYDA-----ELAQMQTHISDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEEIAQ-RSRAEAESWYQSK--YEELQVTAGRHGDDLRNTKQEISEIN--
RMIQRLRSE-I--DHVKK------------------------------------------
-----Q-CA--NLQTAIADAEQ-RGEMAL-KDAKNKL----AGLEDALQKAKQDMARLLK
EYQELMNVKLALDVEIATYRKLIEGEE--------------------------C-RLS-G
EG--VG-QV-------N-ISVVQSTV----------------------------------
------------SGGYGG-------------------------SSSV-------------
---------------------------------------GGGLGLGGGSG----YS----
-----------------------YGSG-----I---G--G--------------------
GFSSG---SGRGIG--GGFS--STGGG-SSTIKYT----TTS--T---------------
------------------------------------------------------------
------------SSRKSYQH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
----------------------------------------------------VSCRLSQE
ARIFLGQQGVR-----G-GSRGFSGGSAVVGGG----RKV--AFSSVS---MSGGA----
-----------------------------------------GRCS-SGGFGSRSLHNLGG
N-KSISMSVAGSRQ-GA-CFGGAGG-----------FGAGGFG-----------------
------A-------GGFGA---------------GGFGAGSFG-----------------
---GGFGG----SFG--GRGGPGFP-VC--PAGGI------QEVTINQSLLTPL----HV
EIDPEIQK--VRTEEREQIKILNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQQQTTST----SSKNL--EPFFE-TYLSALRQQLDTFIN
DKGRLQSELKA-MQDSVEDFKTK-YEDEINKRTA---AENDFVVLK--K---DVDAAYMN
KVELEAKVDALTDEINFLKVLYDA-----ELSQMQTHVSDT----SVVLSMDNNRSLDLD
SIIA-EVRAQYEEIAQ-KSKAEAEALYQIK--VQQLQISVDQHGDNLKNTKTEIAELN--
RMIQRLRAE-I--ENVKK------------------------------------------
-----Q-CQ--TLQASVANAEQ-RGENAL-KDAYSKR----TELEAALQQAKEELARMLR
EYQELMSVKLALDIEIATYRKLLEGEE--------------------------C-RMS-G
ECQSA---V--------SISMVGGGVSAGS------------------------------
---------------VGR-G---LGI-----------------------------SS---
---GFGL------------------------GSGFGSG--SGSGFGF--S-GS-------
----VSSSSGSK------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
----------------------------------------------------------MM
-SSRSRQTYST--------KGGFSSNSASGG---GGSRAHT-SFSSVT-VSRSSGGGGG-
--------------------------T--------------RYGPSKGGFGSRSLYNLGG
N-KSISVSVAGGASSG-RAL----------------------------------------
--------------GSFGLG------------------SGAFS-----------------
-------GLG-------ASRQTFGP-AC--PPGGI------QEVTINQSLLTPL----NV
EIDPEIQR--VRTQEREQIKTLNNKFAAF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQGQNSG--VTRNNQ--EPLFE-AYLGNLRRQLDSIQS
ERGRLDVELRN-IQDLVEDFKSK-YEDEINKRTA---AENEFVVLK--K---DVDAAYMT
RMDLQGRVGTLTQEIDFLQQLYQM-----ELSQVQTHVSDT----NVVLSMDNNRSLDLD
SIIA-EVKAQYELIAQ-RSRAEAEAWYQTK--YEELQVTAGKHGDNLRDTKNEIAELT--
RTIQRLQGE-V--DAAKK------------------------------------------
-----Q-CQ--QLQTAIAEAEQ-RGELAL-KDAKKKL----GDLDMALHQAKEDLARLLR
DYQDLMNVKLALDVEIATYRKLLESEE--------------------------S-RMS-G
ECPSA---V--------SISVTGNSTTVCG------------------------------
-----------------GG--------------VAGFGGGVSLGGS---GG--ASKGGFS
TS----------------------------------------LGYSN----------V--
KGGPVSG--GTSILRKT--TTVKTSSRRY-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTQKSYK--VST--SAPRAFSSRSYSSGPG-----ARI-SSSSF-------------
-------------------------------------------------------SRVGS
-----------------------G-----------SFRSG------------LSTGL---
--------------GL---G----------------------------------------
---------------GGY-AGAG-------GMGGI------TAVTVNQSLLSPL----NL
EVDPNIQA--VRTQEKEEIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWNLLQQ-QKT-----ARSNM--DSMFE-SYINNLRRQLDTLGQ
EKLKLEAELGN-MQGLVEDFKNK-YEEEINKRTE---MENEFVLIK--K---DVDEAYMN
KVELESRLDGLTDEINFLRQLYEE-----EIRELQSQISDT----SVVLSMDNSRSLDMD
SIIA-EVRAQYEEIAN-RSRAEAESVYLTK--YEELQVQAGKHGDDLRRTKTEISDMN--
RNISRLQNE-I--EALKG------------------------------------------
-----Q-RA--ALEASIADAEQ-RGELAL-KDANAKL----AQLEAALRQAKQDMAQQLR
EYQDLMNVKLALDVEIATYRKLLEGEES---------------------------RLE-S
---GM---Q--------NMSIHTKTTSG--------------------------------
---------------YSG---------------------GLSS-----------------
---AYG------------------------------GLTSPGLSYGLSSF-------Q--
--------------------------------TG---------FGSGG---------GSS
SFSRT-------------------S-SRAVVVKKI------ETRDGKLVSESSDVLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------GSI------TTVTVNQTLLSPI----NL
DVDTNIQT--MFTQEKEQIKTLN-KSVSF------INK--GR------------------
----HLE---Q-ILETKWSLLQQ-QEM-----HRSNM--ANMVE-AYINNLWWQLDALGQ
EKLKMEVEVGN-MQGLLEDFKN---EDKVNKHAE---MESEFVLIR--K---DMGEGYMN
KVELESRLEGLKDEINFFRQLYEE-----E-TELQSQVSDT----SVVLPMDNTRSLDLN
SIIT-EVKAQQ-EIAN-RCRVDAEFTYQNK--YGELQTFTGMHGDDLHRMKMGISETN--
-RINQLWAE---IVGLKG------------------------------------------
-----Q-NA--SLEATIADAEQ-HGDLNV-KDAEAKV----TKLEAALRTAKQDIAWQLR
EYQELMNVRLALDVETATYCKLLESEES---------------------------RLE-S
---GI---Q--------NLSIHTKTASG--------------------------------
---------------YSG---------------------GLSSR----------------
---NFR------------------------------DLTSPGLNYGLS------------
------------------------------------------SFHSGG---------ASI
SFSCI-------------------SSSKAVVVKKI------ETRDGKLVSEWSDILLN--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MIGRQYVR-----G-GSRGFSSGSAVVGGG----KRGG-AFSSMS---VSGCA----
-----------------------------------------GRSS-SGGFGSRSLYNLGG
S-KCISMSVAGTRQ-GA-CFGGAGG-----------VGI---------------------
---------------------------------------GGFG-----------------
---SGFGG----SFG--GRGGPGFP-VC--PAGGI------QEVTINQSLLTPL----HV
EIDPEIQK--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWKLLQRQTTTT----SSKNL--EPLFE-AYLSTLRKQLDTLIN
DKGRLQSELKA-MQDSVDDFKTK-YEDEINKRTA---AENDFVVLK--K---DVDAAYMN
KVELEARVDNLNDEISFLRVLYEA-----ELSQMQTQVSDT----SVVLSMDNNRNLDLD
NIIA-EVRAQYEEIAL-KSKAEAEALYQTK--VQQLQLSVDQHGDNLKNTKSEIAELN--
RMIQRLRAE-I--ENVKK------------------------------------------
-----Q-CQ--TLQTSVADAEQ-RGENAL-KDAHSKR----TELETALQQAKEELARMLR
EYQELMSVKLALDIEIATYRKLLEGEE--------------------------C-RMS-G
ECQSA---V--------SISVVSGSASAGS------------------------------
---------------IGG-G---FGG-----------------------------GS---
---GFGL------------------------GGGLGSG--SGSGFGF--G-GG-------
----VSGGSGGKIISTTTLSKRSHR-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MIARQQCVR-----G-RPQGFSCGSAI-VGG----GKKS-AFSSIS---LSGGA----
-----------------------------------------GRCS-SGGFGSRSLYNLGG
K-KSISISVAGARQ-GA-GFGAAGC-----------F-----------------------
------------GAGGFG----------------TGFGAGGFG-----------------
---GGLGG----SFG--GWGGAGSL-VC--PAGGI------QQVTINQSLLTPL----HV
EIDPEIQK--VRT QEREQIKILNDKFASF------IDK--VR------------------
----FLEQQ---------------KTTT----SSKNL--DPFFE-AYISALRKQLDTLTN
DKGYLQSELKI-MQDSVEDFKAK-YEEEINKRTA---AENDFVVLK--K---DVDAAYMN
KVELEAKVDGLNDEINFLRILYAA-----ELSQMQTHVSDT----SVVLSMDNNRDLDLD
SIIA-EVRAQYEEITQ-RSKAEAEALYQIK--IQQLQISVDQHGDSLKNTKNEISELN--
RMIQRLRAE-I--ENIKK------------------------------------------
-----Q-CQ--TLQGSVADAEQ-RGEAAL-KDAYSKR----AELEAALKKAKEELARMLR
EYQELMSVKLALDIEIATYRKLLEGEE--------------------------C-RMS-G
ECQSA---V--------SISVVGGAASAGG------------------------------
---------------IGSGG---VGS----C---SGFG--LGA-----------------
---------------------------------GFGSG--SGSGFGF--G-SG-------
----VCGSAGSKIISTTTTSTLT--KRSQ----R--------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--M-SRQSTIT--FQTG-SRRGFSTTSATTPA-----SGRS-RFSSVS-MTRSTG--GSG
RLGRIS--------------------------GP------------GTSFGSRSLYNLAG
T-KRVSISGC-GSN-----FQS----------------G--RA----SSGFGV-----S-
--------------SGSGYG--GGVGGGF-------------------------------
--------------GP-SFP------VC--PAGGI------QEVTVNQSLLTPL----NL
QIDPTIQR--VRKEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWSLLQEQGSK----TVRQNL--EPFFD-AYLNDLRRQLDNVTT
ESGRLDAELRN-MQDVVEDFKVK-YEDEINKRTA---AENEFVALK--K---DVDASYMN
KVELEAKVSCLTDEINFLRMLYEE-----ELSQMQTQVSDT----SVVLSMDNNRSLDLD
GIIA-EVKAQYEDIAN-RSRAEAESWYQTK--YEELQVSAGRHGYDLRNTKQEISEMN--
RMIQRLRAE-I--DSIKK------------------------------------------
-----Q-YA--SLQSAIADAEQ-RGELAL-KDARAKL----VDLEEALQKAKQDMARLLR
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VS-PVNIS--------VVTSTV----------------------------------
------------SSGYGGGS--GIG-----------------------------------
---------------------------------------GGSLGLGGGSG----YSFTT-
-----------------------SG-------GHSLG--A--GLGG-------------S
SFSAS---SNRGLGG------------SGSSVKFV----STTS-----------------
------------------------------------------------------------
------------SSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--TMSSKSTMR--SQ-SISHRGFSASSARVPG-----VCRS-GFSSVS-VSRSRGSGGFG
G-------------------------------AC-----------GGAGFGSRSLYGLGG
S-KRISIGGG----SC--AISGG-------------YGG--RV----GGGFGYGGGA-S-
--------------SGFGFG--GA--A------GG-----------------GF----GL
G--GG-PGFAG-GYGSSGFP------VC--PPGGI------QEVTVNQNLLTPL----NL
QIDPTIQR--VRTEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVRQNL--EPLFE-QYINNLRRQLDSILG
ERGRLDSELRN-MQDTVEDFKNK-YEDEINKRTA---AENEFVTLK--K---DVDAAYMN
KVELQAKVDALTDEINFTRALYDA-----ELSQMQTHVSDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEEIAQ-RSRAEAESWYQSK----ELQLTAGRHGDDLRNTKQEISEIN--
RMIQRLRSE-I--DHVKK------------------------------------------
-----Q-CA--NLQSAIADAEQ-RGEMAL-KDAKNKL----ADLEDALQKAKQDMARLLK
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VG-QV-------N-ISVVQSTV----------------------------------
------------SGGYGSAGGY-----------------GS--ASGM-------------
---------------------------------------GGGSGLGGGSG----YS----
-----------------------YGSG-----H-SLG--A--------------------
GFSSS---SGRGMG--GGFS--SSGGS-SSTIKYT----TTS--S---------------
------------------------------------------------------------
------------SSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
-----------------------------------AELGVRAAERGHGRGHGPSRRVP--
--------------SPPGVSCPPSRRVPSPP-G----VSCP-RGGGG----GGGGGGGG-
GGGGGGGGGGGGGGGGGGGGGGGGGGRGGGGGGGGGGGGGGGGGGGGGGFGSASLYSLGS
AGKRISLGGGSSLG-G-GSAFGVRS-----------------------------------
---------------GYGYG----------------------------------------
-------------Y------GAAGL-----GGSGI------QEVTVNQSLLTPL----SL
EIDPSIQR--VRKEEKEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQEQKTT-----RS-NI--APMFE-TYISNLRRQLDGLLA
DKGRLEGELRN-MQDLVEDFKTK-YEDEINKRTA---AENEFVVLK--K---DVDAAYMN
KVELEAKVDALTDEINFLRAFHEA-----ELNELQAQISDT----SVVLSMDNSRSLDLD
SIIA-EVKAQYEDIAN-RSRAEAESWYQSK--YEALQVTAGKHGDDLRNTKNEITEIN--
RVIQRIQGE-I--ENAKA------------------------------------------
-----Q-RA--KLEAAVAEAEE-RGELAL-KDARAKL----EELEAALQKAKADMARQLR
EYQELMNVKLALDIEIATYRKLLEGEE--------------------------S-RLA-G
DGVGN---V--------NISVVSSSGSSKVSSGG--------------------------
-G----GG-G----------------------------GGGGGGGGGGGGG-GGGGGGGG
GGGGGGGGGGGG------------------------------------------------
--------GGGGGGGGGGG-GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG-GGGGG
GGGGG--GGGGGGGGGG-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MNRQVCKK--SF-SSGSQGFSGHSTVVS-G-----SSR-M-SS---VARSRGA-S--
-----GG-------------------------ACGFR----SAA---GGFGSRSLHNLGG
K-RSISISVAAGGS-RAGSFG-GRS------VCG----GGYGSS----FGGGYGGGFGGG
--F--GRGGGFG-------------------------------GAGGFGGAGGF------
GGPGGFGGAG--GFGG---AGGFGP-GG--FPGGI------QEVTVNQSLLQPL----NV
EXXXXXXX--XXXXXXXXXXXXXXXXXXX------XXX--VR------------------
----FLEQQNK-VLETKWNLLQQQTTGSG--SGPNNL--EPVFE-SYISYLRRQLDLLLG
ERGNLDGELKN-VQDLVEDFKKK-YEDEINKRAA---AENEFVGLK--K---DVDVAYMN
KVDLQARVDSLTDEISFLRTLYEM-----ELSQMQTLVSDM----SVVLTMYNNYH--LD
SIFF-EVRA-LHLIAQ-KSKADVEAQYQTK--LGELQTRAGRHGDDLRNTKSEIMEIN--
RMIQRLRAE-I--ENVKK------------------------------------------
-----Q-NA--NLQAAIAEAEQ-HGELAV-KDADAKL----QSLQAALQQAKDDLARLLR
DYQELMNVKLALDVEIVTYRKLLEGEE--------------------------C-RMS-G
ECQSA---V--------SISVVNSVST---------------------------------
---------SSSSGGSQGGFGGISGS----SS--AGYRGSSSSGG---------I-----
--------------RSSG-------------------------GGYGGVS-GS---SS--
GGRGSSGGYQ--------------------SGSS------GSRLGGGGSSS---VSRSGI
GSSSG--SF-QSSGGSGYKS----ASGGST------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSSKTTVR--SQS-TSRRGFSASSARVPG-----LSRS-GFSSVS-VCRSRGSGGTG
A-------------------------------MY-----------GGAGFGSRSLYNLGG
S-KRISIGGG----SC--AIGGG-------------YGS--RV----GGGFGFGGGI-G-
--------------NGFGYG--GG--A------GS-----------------GF----GL
S--GG-AGFGG-GYGGAGFP------VC--PPGGI------QEVTINQSLLTPL----NL
EIDPTIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWSLLQEQGTR----TVRHSL--EPLFE-QYINNLRRQLDSIVS
ERGRLDSELRN-MQDAVEDYKNK-YEHEINKRTT---AENEFVTLK--K---DVDAAYMN
KTELQAKADGLVDEINFLRALYEA-----ELSQMQTQVSDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEDIAN-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEISEVN--
RMIQRLRAE-I--DSVKK------------------------------------------
-----Q-CS--SLQTAIADAEQ-RGELAL-KDARAKL----VDLEEALQKAKQDMARLLR
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RGQ-S
VG--RM-ELSQRTQ--V-QSVVTSTV----------------------------------
------------SSGYGSGG-------------------GI--A----------------
---------------------------------------GGSLGLGGG-S----SYSFT-
-----------------------TSGG--------------HSLN--------------T
GLGSS---G---FT--TSSS--RGPAGSGSSIKFI----STTS-----------------
------------------------------------------------------------
------------SSRKNYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSSKSTMR--SH-SSSHRGFSAGSARVPG-----VSRS-GFSSVS-VSRSRGSGGLG
A-------------------------------VC-----------GGAGFGSRSLYNLGG
S-KRISIGGG----SC--AVSGG-------------YGS--RV----GGGFGFGGGA-G-
--------------SGFSFG--GG--A------GG-----------------GF----GL
G--GG-AGFGG-GFGGAGFP------VC--PPGGI------QEVTINQNLLTPL----NL
QIDPTIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVRQNL--EPLFE-QYISTLRRQLDSILG
DKGRLDSELRG-MQDLVEDFKNK-YEDEINKRTA---AENEFVTLK--K---DVDAAYMN
KVELQARVDSLTDEINFLRAFYDA-----ELSQMQTHISDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEEIAQ-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEIAEMN--
RMIQRLRSE-I--DHVKK------------------------------------------
-----Q-CA--NLQAAIADAEQ-RGEMAL-KDARSKL----EGLEDALQRAKQDMARLLK
DYQELMNVKLALDMEIATYRKLLEGEE--------------------------C-RLN-G
EG--VG-QV-------N-ISVVQSTV----------------------------------
------------SGGYGGAGG-------------------------V-------------
---------------------------------------GSGLALGGGSG----YS----
-----------------------YSGG--------------HSLG--------------G
GFSSS---SGRGLG--GGLS--SVGGS-SSSIKYT----TTTT-S---------------
------------------------------------------------------------
------------SSKKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MNRQVCKK--SF-SGGSQGFSGHSAVVS-G-----SSR-I-SC---VARSGGV-G--
-----GG-------------------------ACGLR----SRA---GGFGSCSLYNLGG
N-KSISISVAAGGS-QAGAFVGGQS------SCG--FAGGYGGG----FGGSYGGGFGGG
--R--GIGSGFG-------------------------------GAGGFGGAGGF------
GGPGVFGGLG--SFGS---PGGFVS-GG--FPGGI------QEVTVNQSLLQPL----NV
EIDPQIGQ--VKA QEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWELLQQQTTG----SGPSSL--EPCFE-SYISFLRKQLDSLLA
ERGNLEGELKS-MQDLVEDFKKK-YEDEINKRTA---AENEFVGLK--K---DVDAVFMN
KVELQAKVDSLTDEVSFLRTLYEM-----ELSQMQSHVSDM----SVVLSMDNNRCLDLD
NIIA-EVRAQYEEIAQ-RSKAEAEALYQTK--LGELQTTAGRHGDDLRNTKSEIMELN--
RMIQRLRAE-I--ENVKK------------------------------------------
-----Q-NA--NLQTAISEAEQ-RGEMAL-KDANAKL----QDLQAALQKAKDDLARLLR
DYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RMS-G
ECQSA---V--------CISVVSNVTST--------------------------------
---------SGSSGSSRGVFGGASGS--------GGYRGSGSSS----------------
-------------------GSSG-YGGVSG---------GSSSS-YRGVS-SG---ST--
GGRGSSGGYQ--------------------SSSS------GSRLGGAGSIS---MSHRGM
GSSSG--GV-QTSGGSGYKS----GGGGSTSIRFS----QTT------------------
------------------------------------------------------------
----------SSS-QHNSNK----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTQKSYN--VST--SGPWAFRSCSYTSGPG-----AHI-S-----------------
-------------------------------------------------------SSMGS
S----------------------------------SFRGG------------LGAGY---
--------------A---------------------------------------------
------------------GASGM-------GMGGI------TAVNVNQSLLSPL----NL
EVDPNIQA--VRT QEKEQIETLNNKFASF------IDK--VW------------------
----FLEQQNK-MLETKWSLLQQ-QKT-----ARSNM--DNMFE-SYINNLRRQLETLGQ
EKLKLEAELGN-MQGLVEDFKNK-YEDEINKHTE---MENEFVLIK--K---DVDEAYMN
KVELESRLEGLTDEINFLRQLYEE-----EIQELQSLISDR----PVALSMDNSRSLGMD
SIIS-EVKAQYEEIAN-HSQAEAENVYRIK--HEKLQTLAGKHGDDLRCTKTEISEMN--
RNISRLQ-----------------------------------------------------
-------RA--SLEATIADAEE-RGDLAL-KDAHAKQ----KELEAALQQAKQDMALQLR
EYRELMNVKLALDIEIATYRKLLEGKES---------------------------RLE-S
---EM---H--------NMSIHMKTASG--------------------------------
---------------YAG---------------------GLSS-----------------
---ANG------------------------------GLTSPGLSYGLG------------
---------------------------------S--------SFGSGT---------GPS
SSSCT-------------------RSTKAVVVKKI------ETHGGRLVSESSDVLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MNRQACKK--SF-SCGSQGFSGRSSVVSGG------SR-M-SC---VARTRVS-G--
-----GG-------------------------ASGFR----SG---AGGFGSHSLYNLGG
N-KSISISVAAGGS-RAGSFGGGHS------SCSSGFGS----GFGGNRG----------
------MGN-------------------------------------------GFGGAGGF
GGAG--------GFSG---PGGFGP-GC--FSGGI------QEVTVNQSLLQPL----NV
EIDPQIGQ--VKA QEWEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQQQTAGSG--SAPRSL--EPFFD-SYISFLHKQLDSLLE
DRGNLEGELKN-TQDLVEDFKKK-YEDEVNKRTA---AENKFVGLK--K---DVDATYMT
KVELQAKVDSLADEVNFLRTLYDM-----ELSQMQRDVSDT----SVVLSMDNNRDLDLD
SIIA-EVRVQYEEIAQ-RSKAEAEALYQTK--LGELQTTAGRHGDDLKSTRSEIMELN--
RMIQRLQAE-I--ENVKK------------------------------------------
-----Q-NA--NLQSSIEEAEQ-RGETAL-NDANAKL----QDLKAALQQAKDGLARLLR
DYQELMNIKLALDVEIATYRKLLEGEE--------------------------C-RMS-G
ECQNA---V--------SISLVNNVTC---------------------------------
--------TSSSSGSSHGGFRGINGN----SS--NGS---S--GG---------------
----------------SRGSSN------------------------GEGS--SGSGSV--
GR---------G------------NNRGYQSPSS------GSRLGSGGNS--SV-SQSGT
GFSAD--VT-QNSVGSGYKS----GKAGSISVHFS----KTT------------------
------------------------------------------------------------
----------SSS-QQRSK-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTQKSYKARVS--TSSPRAFSSRSYTRGPG-----SRI-SSSAF-------------
-------------------------------------------------------SRVGS
C---------------------GG-----------SFPGG------------LNSSM---
--------------SVVG------------------------------------------
-----------------GYGGPG-------AVGGI------TAVSVNQSLRSPL----KL
EVDPNIQV--VRTQEKEQIKSLNNKFASF------IDK--VR------------------
----HLEQQNK-ILEAKWGLLQQ-QKT-----ARSST--DNMLG-SCIHDLRRQLDTPAQ
EKLTLEVELGD-LQGLVEGFKNK-YEDEIKLRGD---LENEFVLIK--K---DVDEAYMH
KTELEPRGEGLTDEINSG-QRHEE-----ETRELQSQISDP----SAVPSRGNSRALDLD
GVTA-EVKAQNEDIAH-RRRAQAETMHRIK--CEELQTLAGKHGDDLRRTKT-ISEMN--
RSIRRLRAE-I--EALRN------------------------------------------
-----Q-RA--APEAAVADAEP-RGEAVKDANAQVAE----PEPEAALQRDERDMARQLR
EHRELLNVRLAPDLEMGDRHRPTLGEES---------------------------RLE-P
---GM---Q--------NTSIHRKTTSG--------------------------------
---------------YPG------------------------------------------
------------------------------------GLTSPRPSYGQS--------PF--
--------------------------------QS--------SFG--------------P
SFSRS-------------------SSSKAAVVEKI------ETRDGKLVSAWSDVLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQACKQ--SF-SRGSQGFSGHSAVVSG------SSR-R-SC---VARTRAA-G--
-----GG-------------------------ACGFR----SG---AGGFGSQSLYNLGG
S-RSISISVAAGGS-QTGGFGRGHG------SCGSGFGGGYGGGFGGSRG----------
------I-----------------------------------------------GGASGF
GGAS--------GFGR---PGGFGP-GS--CPGGI------QEVTINQSLLQPL----NV
EIDPQIGE--VKA QEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQQQTTGSG--SGPQSL--EPFFE-SYISCLRKQLDSLLG
EKGSLEGELKN-MQDLVEDFKKK-YEEEINRRTA---AENEFVEVK--K---DVDVAYMN
KVELQAKVDSLTDEINFLRTLYDM-----ELSQMQSHVSDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEEIAQ-RSKAEAEALYQTK--LGELQTTAGRHGDDLKSTKSEIMDLN--
RMIQRLRAE-I--ENVKK------------------------------------------
-----Q-TA--NLQTSIAEAEQ-RGEGAL-KDADAKL----QDLQAALQKAKDDLARLLR
DYQELMNVKLALDVEIATYCKLLEGEE--------------------------C-RMS-G
ECQSA---V--------SISVVSNVTS---------------------------------
--------TSSS----SGGFRGAGGS----GG--S----SI-------------------
----------------S-GDFR--------------------------GD--S-------
-----------S------------VSNSCSRDST------GSRLGREDSS--SV-GQRGM
G-------T-QASTGGSYKS----GRGGSGSVHFF----QTT------------------
------------------------------------------------------------
----------SSS-QQRSK-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--M-SRQSSIT--FQSG-SRRGFSTTSATTPA-----AGRS-RFSSIS-VAHSAA--GSG
GLGRIS--------------------------SA------------GASFGSRSLYNLGG
A-KRVSISGC-GSS-----FRSG-------------FGG--RA----SNGFGV-----N-
--------------SGFGYG--GGVGGGF-------------------------------
--------------SGPSFP------VC--PSGGI------QEVTVNQSLLTPL----NL
QIDPTIQR--VRAEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQGSR----TVRQNL--EPLFD-SYISELRRQLESVTT
ERGRLEAELRN-MQDVVENFKVR-YEDEINKRTA---AENEFVALK--K---DVDAAYMN
KVELEAKVKSLPEEINFLHSVFDA-----ELSQLQTQVSDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEDIAN-RSRAEAESWYQTK--YKELQVTAGRHGDDLRNTKQEISEMN--
RMIQRLRAE-I--DSVKK------------------------------------------
-----Q-CS--SLQTAIADAEQ-RGELAL-KDARAKL----VDLEEALQKAKQDMARLLR
EYQELMNIKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VS-PVNIS--------VVTSTL----------------------------------
------------SSGYGSGS--SIG-----------------------------------
---------------------------------------GGSLGLGGGSG----YSFTT-
-----------------------SG-------GRSLG--A--GLGG-------------S
GFSAT---SNRGLGG------------SGSSVKFV----STTS-----------------
------------------------------------------------------------
------------SSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
MA--STSTTIR--SH-SSSRRGFSASSARLPG-----VSRS-GFSSVS-VSRSRGSGGLG
G-------------------------------AC-----------GGAGFGSRSLYGLGG
S-KRISIGGG----SC--AISGG-------------YGS--RV----GGSYGFGG-A-G-
--------------SGFGFG--GG--A------GI-----------------GF----GL
G--GG-AGLAG-GFGGPGFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPAIQR--VRA EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVRQNL--EPLFE-QYINNLRRQLDSIVG
ERGRLDSELRN-MQDLVEDLKNK-YEDEINKRTA---AENEFVTLK--K---DVDAAYMN
KVELQAKADNLTDEINFLRALYDA-----ELSQMQTHISDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEEIAQ-RSRAEAESWYQTK--YEELQVTAGRHGDDLGNTKQEIAEIN--
RMIQRLRSE-I--DHVKK------------------------------------------
-----Q-CA--NLQAAIADAEQ-RGEMAL-KDAKNKL----EGLEDALQKAKQDLARLLK
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLN-G
EG--VG-QV-------N-ISVVQSTV----------------------------------
------------SSGYGGASS-------------------------V-------------
---------------------------------------GSGLGLGGGSG----YS----
-----------------------YGSG--------------LGVG--------------G
GFSSS---SGRATG--GGLS--SVGGG-SSTIKYT----TTSS-----------------
------------------------------------------------------------
------------SSRKSYRH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
----------------------------------------------------------MR
-SSVSRQTYST--------KGGFSSNSASGG---SGSQART-SFSSVT-VSQSSGSGGG-
--------------------------A--------------RCGPGTGGFGSRSLYNLGG
H-KSISVSVAGGASSG-RAL----------------------------------------
--------------GGFGFG------------------SRAFM-----------------
-------GQG-------AGRQTFGP-AC--PPGGI------QEVTVNQSLLTPL----HV
EIDPEIQR--VRTQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQGQNLG--VTRNNL--EPLFE-AYLGSMRSTLDRLQS
ERGRLDSELRN-VQDLVEDFKNK-YEDEINKRTA---AENEFVVLK--K---DVDAAYMG
RMDLHGKVGTLTQEIDFLQQLYEM-----ELSQVQTHVSNT----NVVLSMDNNRNLDLD
SIIA-EVKAQYELIAQ-RSRAEAEAWYQTK--YEELQVTAGKHGDNLRDTKNEIAELT--
RTIQRLQGE-A--DAAKK------------------------------------------
-----Q-CQ--QLQTAIAEAEQ-RGELAL-KDAQKKL----GDLDVALHQAKEDLTRLLR
DYQELMNVKLALDVEIATYRKLLESEE--------------------------S-RMS-G
ECPSA---V--------SISVTGNSTTVCG------------------------------
-----------------GG--------------AASFGGGISLGGS---GG--ATKGGFS
TN----------------------------------------VAYST----------V--
KGGPVSG--GTSILRKT--TTVKTSSQRY-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQSSVS--FR-SGGSRSFSTASAITPS-----VSRT-SFSSV---SRSGG----G
GGGRVS--------------------------LG-------VA-GGAGGYGSRSLYNLGG
S-KRISISAS----GG--GFRNR-------------YGAGSGS----G--FGFGGGA-G-
--------------GGFGFG--GGAG-G------------------------GF----GL
G--GGAGFG-G-GYGGAGFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPTIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTR----TVKQSL--DPLFE-QYINNLRRQLDSILG
ERGRLDSELRN-MQDLVEDFKNK-YEDEINKRTT---AENEFVMLK--K---DVDAAYMN
KVELEAKVDALMDEINFTKMFFDA-----ELSQMQTHVSDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEDIAN-RSRTEAESWYQTK--YEELQQTAGRHGDDLRNTKHEISEMN--
RMIQRLRAE-I--DNVKK------------------------------------------
-----Q-CA--NLQSAIADAEQ-RGELAI-KDARNKL----AELEDALQKAKQDMARLLR
EYQELMNTKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VG-PV-------N-ISVVTNSM----------------------------------
------------SAGYGGGS--GFGS----G---SSYVS----GTGLGSG----L-----
-----G----------------------------------------GGGG----SSYYS-
-----------------------SSSG-----GVGLG--GGLSVGG-------------S
GFSSS---SGRGIGAGFGS----AGG-SGSTVKFV----STTS-S---------------
------------------------------------------------------------
-------------SRRTFKS----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTQKSYK--VST--SGPGAFSSRSFTSGPS-----ARL-S-----------------
-------------------------------------------------------SRVST
S----------------------------------SFRGG------------LGAGY---
--------------A---------------------------------------------
------------------GASGI-------GMGGI------TAVTINQSLLNPI----KM
DVGPNIQA----------IKTLNNKFASF------IDK--VR----------------------FLKQQNK-MLETKWSLLQQ-QKT-----AWSNM--DNMFE-SYINNLRRQLETLGQEKLKLEAELGN-MQGLVEDFKNK-YEEEINKCTE---MEDEFVLIK--K---DVDEAYMNKVELESRLEGLIDEINFLRQLYEE-----EIRELQSQISDT----SVVLSMDNSRSLDMDSIIA-EVKAQYKEIAS-RSRAEAVSVYQIK--YEELQTLAGKHGDDLQRTKTEISEMN--RNVSQLQAE-I--EGLKG-----------------------------------------------Q-RA--SLEAAIADAEH-RGELAL-KDARAKQ----QELEIALQRAKQDMARQLCEYKELMNVKLALDIEIATYRKLLEGEES---------------------------QLE-S---GM---Q--------NMSIHTKTTSG-----------------------------------------------YAG---------------------GLSS--------------------AYG------------------------------GLTSPGLSYGLG---------------------------------------------S--------SFGSGV---------GSSSISRT-------------------SSTKAVVVKKI------ETHDGRLVSESSDVLPK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IKTLNNKFASF------IDK--VR------------------
----FLKQQNK-MLETKWSLLQQ-QKT-----AWSNM--DNMFE-SYINNLRRQLETLGQ
EKLKLEAELGN-MQGLVEDFKNK-YEEEINKCTE---MEDEFVLIK--K---DVDEAYMN
KVELESRLEGLIDEINFLRQLYEE-----EIRELQSQISDT----SVVLSMDNSRSLDMD
SIIA-EVKAQYKEIAS-RSRAEAVSVYQIK--YEELQTLAGKHGDDLQRTKTEISEMN--
RNVSQLQAE-I--EGLKG------------------------------------------
-----Q-RA--SLEAAIADAEH-RGELAL-KDARAKQ----QELEIALQRAKQDMARQLC
EYKELMNVKLALDIEIATYRKLLEGEES---------------------------QLE-S
---GM---Q--------NMSIHTKTTSG--------------------------------
---------------YAG---------------------GLSS-----------------
---AYG------------------------------GLTSPGLSYGLG------------
---------------------------------S--------SFGSGV---------GSS
SISRT-------------------SSTKAVVVKKI------ETHDGRLVSESSDVLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MIARQQCVR-----G-GPRGFSCGSAIVGGG----KRG--AFSSVS---MSGGA----
-----------------------------------------GRCS-SGGFGSRSLYNLRG
N-KSISMSVAGSRQ-GA-CFGGAGG-----------FGTGGFG-----------------
------A-------GGFGA----------------GFGTGGFG-----------------
---GGFGG----SFS--GKGGPGFP-VC--PAGGI------QEVTINQSLLIPL----HV
EIDPEIQK--VRT EEREQIKLLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQQQTTTT----SSKNL--EPLFE-TYLSVLRKQLDTLGN
DKGRLQSELKT-MQDSVEDFKTK-YEEEINKRTA---AENDFVVLK--K---DVDAAYMN
KVELEAKVDSLNDEINFLKVLYDA-----ELSQMQTHVSDT----SVVLSMDNNRNLDLD
SIIA-EVRAQYEEIAQ-RSKAEAEALYQTK--VQQLQISVDQHGDNLKNTKSEIAELN--
RMIQRLRAE-I--ENIKK------------------------------------------
-----Q-CQ--TLQASVADAEQ-RGENAL-KDAHSKR----VELEAALQQAKEELARMLR
EYQELMSVKLALDIEIATYRKLLEGEE--------------------------Y-S----
-----------------------GSTSAGG------------------------------
---------------ISG-G---LGS-----------------------------GS---
---GFGL------------------------SSGFGSG--SGSGFGF--G-GS-------
----VSGSSSSKIISTTTLNKRR-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MASKTTMR--TQSTSSHRGFNASSARVPR-----PSHF-GFSSVS-MSHSGRGALH-
------------------------------------------------------------
------------------------------------------------------------
-------------------G----------------------------------------
------------------------------------------------------------
--------------------------EGE------AGS--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVRQSL--EPLFE-QYINNLRRQLDSILG
ERGRLDSELRS-MQDLVEDFKNK-YEDEINKRTA---AENEFVTLK--K---DVDAAYMN
KVELQAKVDGLTDEINFLRAFYDA-----ELSQMQTQISDT----SVVLSMDNNRHLDLD
SIIA-EVRAQYEDIAQ-RSRAEAEAWYQTK--YEELQVTAGRHGDDLRNTKQEIAEIN--
RMIQRLRSE-I--DHVKK------------------------------------------
-----Q-CA--NLQAAIADAEQ-RGELAL-KDARSKL----EGLEDALQKAKQDMARLLK
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VG-QV-------N-ISVVQSTM----------------------------------
------------SSGYGSGS-------------------GS--GYGS-------------
---------------------------------------GSGLALGGG-S----SYSY--
------------------------SSG--------------HDLG--------------G
GFSSG---STRGLG--GGLS--SAGGS-TSSVKYT----TTTS-----------------
------------------------------------------------------------
-------------SRRSYRQ----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------GGFGTRSLHNLGG
S-KRIS-VSG----SY--HSSRA-------------GFA-------------------C-
------------------------------------------------------------
----------S-GFGFGSGM------MS--GAGGI------QEVTVNQSLLTPL----HL
EIDPSLQR--VRKEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWSLLQEQ--K----TTRANI--EPMFE-AYISNLRRQLEGLGG
ERGRLETELKS-MQDVVEDFKNK-YEEEINRRTA---AENEFVVLK--K---DVDAAYMN
KVELEAKVDALMDEINFLRAFYDA-----ELAQLQAQISET----SVVLSMDNNRKLDLD
SIIA-EVKAQYEDIAN-RSRAEAESWYQIK--YEELQQSAGRHGDDLRTTKMEISELN--
RMIQRLRSE-I--DNLKK------------------------------------------
-----Q-CA--TLQAAISDAEQ-RGELAL-KDAKHKL----TELEDALQKAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEECR---------------------------LT-G
EG--VG-PV-------N-ISVVSSSG----------------------------------
------------GTGYSGGGGL--------------------------------------
---------------------------------------CV-------------------
-------------------------G--------------GSGYG--------------A
GFSST---SGRSMG--GSTS--SMRI-ISK------------T-----------------
------------------------------------------------------------
------------STKRSYRS----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--M-SRQSSIT--FQSG-SRRGFSTASATTPA-----TGRS-RFSSVS-VARSAA--GNG
GLGRIS--------------------------SA------------GASFGSRSLYNLGG
A-KRVSISGC-GSS-----FRSG-------------FGG--RA----SSGFGV-----N-
--------------SGFGYG--GGVGGGF-------------------------------
--------------TGPSFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPAIQR--VRAEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQGSR----TVRQNL--EPLFD-SYISELRRQLESLTT
ERGRLEAELRN-MQDVVEDFKVR-YEDEIKKRTA---AENEFVALK--K---DVDAAYMN
KVELEAKVKSLPEEINFLHSVFDA-----ELSQLQTQVSDT----SVVLSMDNSRNLDLD
SIIA-EVKAQYEDIAN-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEISEMN--
RMIQRLRAE-I--DSVKK------------------------------------------
-----Q-CS--SLQTAIADAEQ-RGELAL-KDARAKL----VDLEEALQKAKQDMARLLR
EYQELMNIKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VS-PVNIS--------VVTSTL----------------------------------
------------SSGYGSGS--GIG-----------------------------------
---------------------------------------GGSLGLGGGSG----YSFTT-
-----------------------SG-------GHSLG--A--GLGG-------------S
GFSAS---SNRVLGG------------SGSSVKFV----STTS-----------------
------------------------------------------------------------
------------SSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MNRQVCKK--SF-SGRSQGFSGRSAVVS-G-----SSR-M-SC---VARSGGA-G--
-----GG-------------------------ARGFR----SGA---GSFGSRSLYNLGS
N-KSISISVAAGGS-RAGGFGGGRS------SCG--FAGGYGGG----FGGSYGGGFGGG
--R--GVGSGFG-------------------------------GAGGFGGAGGFGGPGVF
GGPGSFGGPG--GFG----P------GG--FPGGI------QEVIVNQSLLQPL----NV
EIDPQIGQ--VKA QEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLATKWELLQQQTTG----SGPSSL--EPCFE-SYISFLRKQLDSLLG
ERGNLEGELKS-MQDLVEDFRKK-YEDEINKRTA---AENEFVGLK--K---DMDAAFMS
KVELQAKVDSLTDEVSFLRTLYEM-----ELSQMQSHVSDT----SVVLSMDNNRCLDLD
SIIA-EVRAQYEEIAQ-RSKAEAEALYQTK--LGELQTTAGRHGDDLRNTKSEIMELN--
KMIQRLRAE-I--ENVKK------------------------------------------
-----Q-NA--NLQTAIAEAEQ-RGEMAL-KDANAKL----QDLQAALQKAKDDLARLLR
DYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RMS-G
ECQSA---V--------CISVVSNVTST--------------------------------
---------RGSSGSSRGVFGGVSGS----GS--GGYKGGSSSSS---------------
----------------------G-Y-GVSG---------GSGSGYGGVSS-GS---TG--
GR-GSSGSYQ--------------------SSSS------GSRLGGAGGIS---VSHSGM
GSSSG--SI-QTSGGSGYKS----GGGGSPSIRFS----QTT------------------
------------------------------------------------------------
----------SSS-QHSSTK----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQSSVS--FR-SGGSRSFSTASAITPS-----VSRT-SFTSV---SRSGG--GGG
GFGRVS--------------------------LG-------GACGV-GGYGSRSLYNLGG
S-KRISISTS----GG--SFRNR-------------FGAG--A----GGGYGFGGGA-G-
--------------SGFGFG--GGAG--------G-----------------GF----GL
G--GGA-GFGG-GFGGPGFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPSIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVRQNL--EPLFE-QYINNLRRQLDSIVG
ERGRLDSELRN-MQDLVEDFKNK-YEDEINKRTT---AENEFVMLK--K---DVDAAYMN
KVELEARVDALMDEINFMKMFFDA-----ELSQMQTHVSDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEEIAN-RSRTEAESWYQTK--YEELQQTAGRHGDDLRNTKHEISEMN--
RMIQRLRAE-I--DNVKK------------------------------------------
-----Q-CA--NLQNAIADAEQ-RGELAL-KDARNKL----AELEEALQKAKQDMARLLR
EYQELMNTKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VG-PV-------N-ISVVTSSV----------------------------------
------------SSGYGGGS-G--------------YGG--GLGGGLGGG----L-----
-----GGGLGGGL--------------------------GGGLG-GGSSG----SYYSS-
------------------------SSG-----GVGLG--GGLSVGG-------------S
GFSAS---SGRGLGVGFGS---GG-G-SSSSVKFV----STTS-S---------------
------------------------------------------------------------
-------------SRKSFKS----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------M--
----NRQVCKT--S--GGGSQGFSGRSAVVSG------SSR-M-SS---VARSGGA-S--
-----GG-------------------------ACGFR----GG---AGGFGSRSLYSLGG
N-KSISISVAG-GS-RAGGFGGGRS------SSGSVFGGGYGGGFGGGYGGGFGGGR---
-------A------GGFG--------GAGGFGGA-----GGFGGPGGFGGPGGF------
-------GPG--GFGG---P------GG--FPGGI------QEVTVNQSLLQPL----NV
EIDPQIGQ--VKTQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWSLLQQQGTNSI--TGTNNL--EPLFE-NYISTQRSYLDSILG
ERGRLDSELRN-MQDLVEDFKRK-YEDEINKRTA---AENDFVTLK--K---DVDAAYMN
KVELQAKVDALMDEINFLTTLYDM-----ELSQMQSHVSDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEDIAQ-RSKAEAEALYQTK--LGELQTTAGRHGDDLKNTKSEIMELN--
RMIQRLRAE-I--ENVKK------------------------------------------
-----Q-NA--NLQTAIAEAEQ-RGELAL-KDANAKL----QELQAALQQAKDDLARLLK
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RMS-G
ECQSA---V--------SIWRTRSKAALVASPASRAQRVGSYDTGGW-VLGPITDRCSLL
SPAAVLSSGTSAAGGFGG-----------------T----S-------------------
----------------------------------------AA----------GGFGGG--
L----GGSW---------------------------------GAGGGAGG--GWGRAGGI
SSGSG--VR-CGLSGGGFSS----GSSRGGSIKLS----QSS------------------
------------------------------------------------------------
----------QRS-SR--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------MSIHFSSRSTAYPGR----GAQV-RLSSG----RA-G-----
----------------------------------------------FGS---RSLYGLG-
------------TS-RPRVAV--RS-----------------------------------
---------------AYG------------------------------------------
----------------G-------P-----VGAGI------REITINQNLLAPL----SV
DIDPTIQQ--VRQ EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWALLQDQKSA-----KSSQL--PRIFE-AQIAGLRQQLEALQL
DGGRLEVELRS-MQDVVEDFKNK-YEEEINRRTA---AENEFVLLK--K---DVDAAYTN
KVELEAKADSLQDKINFLKTLHET-----ELAELQSQISDT----CVVLSMDNSRSLDLD
GIIA-DVKAQYEEMAN-HSQAEAEAWYQTK--FETLQAQAGKHGDDLRNTRNEIAEMN--
RSIQKLQAE-I--DTVKN------------------------------------------
-----Q-RA--KLESSIAEAEE-QGELAL-KDARAKL----AEVEEALQKAKQDLARLLR
EYQELMNVKLGLDIEIATYRKLLEGEE--------------------------S-RLS-G
DGMEP---V--------NISV---------------------------------------
----VNS----------TGA----------------NGSRLTIGG-----TMGSNALSF-
-S-----GGPGV------------------------------------------------
--------LRTYSIKTTSTARRGTHH----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--M-SRQSSIT--FQSG-SRRGFSTTSAITPA-----AGRS-RFSSVS-VARSAA--GSG
GLGRIS--------------------------SA------------GASFGSRSLYNLGG
A-KRVSISGC-GSS-----FRSG-------------FGG--RA----SNGFGV-----N-
--------------SGFGYG--GGVGGGF-------------------------------
--------------SGPSFP------VC--PPGGI------QEVTVNQSLLTPL----HL
QIDPTIQR--VRA EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQGSR----TVRQNL--EPLFD-SYTSELRRQLESITT
ERGRLEAELRN-MQDVVEDFKVR-YEDEINKRTA---AENEFVALK--K---DVDAAYMN
KVELEAKVKSLPEEINFVHSVFDA-----ELSQLQTQVGDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEDIAN-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEISEMN--
RMIQRLRAE-I--DSVKK------------------------------------------
-----Q-CS--SLQTAIADAEQ-RGELAL-KDARAKL----VDLEEALQKAKQDMARLLR
EYQELMNIKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VS-PVNIS--------VVTSTL----------------------------------
------------SSGYGRGS--SIG-----------------------------------
---------------------------------------GGNLGLGGGSG----YSFTT-
-----------------------SG-------GHSLG--A--GLGG-------------S
GFSAT---SNRGLGG------------SGSSVKFV----STTS-----------------
------------------------------------------------------------
------------SSQKSYMH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQSSVS--FR-SGGSRGFSAASAITPS-----VSRT-SFTSV---SRSGG--GGG
GFGRVS--------------------------LG-------GAGGA-GGYGSRSLYNLGG
S-KRISISTS----GG--GFRNR-------------FGAV--A----GGGYGFGGGA-G-
--------------SGFGFG--SGAG--------G-----------------GF----GL
G--GGA-GFGG-GFGGPGFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPTIQR--VRTEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTR----TVRQNL--EPLFE-QYINNLRRQLDGILG
ERGRLDSELRN-MQDLVEDFKNK-YEDEINKRTT---AENEFVMLK--K---DVDAAYMN
KVELEAKVDALMDEINFMKMFFEA-----ELSQMQTHVSDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEEIAN-RSRTEAESWYQTK--YEELQQTAGRHGDDLRNTKHEISEMN--
RMIQRLRAE-I--DNVKK------------------------------------------
-----Q-CA--NLQNAIADAEQ-RGELAL-KDARNKL----AELEDALQKAKQDMARLLR
EYQELMNTKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VG-PV-------N-ISVVTNSV----------------------------------
------------SSGYGGGS-G--------------FGG--GLGGGLGGG----------
--------LGGGL--------------------------GGGLG-GGGSG----SYYSS-
------------------------SSG-----GVGLG--GGLSVGG-------------S
GFSAS---SGRSLGVGFGS---GG-G-SGSSVKFV----STTS-S---------------
------------------------------------------------------------
-------------SRKSFKS----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MCM
R--VTQKSYK--VST--SGPRAFSSRSYTSGPG-----AHI-SSSSF-------------
-------------------------------------------------------SRVGS
S----------------------------------CFQGG------------LGGGY---
--------------G---------------------------------------------
------------------GASG---------MGGI------TAVTVNQSLLSPL----VL
EVDPNIQA--VCT QEKEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQQ-QKT---------------------------------
EKLKLEAELGN-MQGLVEDFKNK-YEDEINKRAE---MENEFVLIK--K---DVDEAYMN
KVELESRLEGLTDEINFLRQLYEE-----EIRELQSWISDT----SVVLSMDNSRSLDMN
SVIA-EVKAQYEEIAN-RSRAEAESMYQIK--DEELQSLAGKHGDNLRCTKTKISEMN--
RNISRLQAE-N--EGLKG------------------------------------------
-----Q-RA--FLEAAIADAEQ-CGELAI-KD-----------LEAALQRARQDMAWQLR
EYQELMNVRLALDIEIATYKKLLEGEES---------------------------RLE-S
---GM---Q--------NMSIHTKTTSS--------------------------------
---------------YAS---------------------GLSS-----------------
---ACG------------------------------GLTSPGLSYGLG--------A---
---------------------------------S--------SFS---------------
R---T-------------------SSSRAVVVKKI------ETRDGKLVSESSDVLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--TMSYKSTVK--TQ-SISRKGFSAGSARLPG-----VCRS-GFSSVS-LSRSRGSGGLA
G-------------------------------VC-----------GGAGFGSRSLYGLGG
S-KRISIAGG----SC--AIGGG-------------YGG--RI----GVGYGFGDGA-G-
--------------SGFGFG--AG--A------GS-----------------GF----GL
G--GG-AGFGG-GFGGPGFP------V---------------------------------
QIDPTIQR--VRTEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVKQNL--EPLFE-QYINNLRRQLDSILG
ERGRLDSELRG-MQDTVEDFKNK-YEDEINKRTV---AENEFVNLK--K---DVDAAYMN
KVELQAKVDALTDEINFLRTFYDA-----ELAQMQTHISDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEEIAQ-RSRAEAESWYQSK--YEELRVTAGRHGDDLRNTKQEISEIN--
RVIQRLRSE-I--DHVKK------------------------------------------
-----Q-CA--SLQSAIADAEQ-RGELAL-KDARNKL----ADLEDALQKAKQDMARLLK
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--AG-QV-------N-ISVVQSTV----------------------------------
------------SGGYGGASGL-----------------GS--G----------------
------------------------------------------------LG----AS----
-----------------------YS----------IG--G--------------------
GFSSG---SGRAIG--GGYG--SSGGS-CSTIKYT----TSS--S---------------
------------------------------------------------------------
------------SSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------M--
----NRQSCKK--SF-SGGSQGFSGHSAVVSG------SSR-M-SC---VARSRGA-S--
-----GG-------------------------ACGLR----SG--GGGGFGSHSLYNLGG
T-KSISMSVAGGGS-RAGGFGGGRS-----------------GGFGGGYGGGFGGGFGGG
--R--GMGGGFGGGRGMG----------GGFGGA-----GGFGGAGGFGGPGGFGGPGGF
GGPGGFGGPG--GFGG---PGGFGP-GG--FPGGI------QEVTVNQSLLQPL----NV
EIDPQIGQ--VKTQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWELLQQQTTGSG--SGPQNL--EPLFE-SYISFLRKQLDSLLS
EKGNLNTELKT-MEDMVEDFKKK-YEDEITKRTA---AENEFVRLK--K---DVDTAYMN
KVELQAKTDSLTDEINFLRTLYDA-----ELSQMHTQVSDT----SVVLSMDNSRSLDLD
SIIA-EVKAQYEEIAN-RSRAEAEAWYQTQ--LGELQTTAGRHGDDLKSTKSEIMELN--
RMIQRLRAE-I--ENIKK------------------------------------------
-----Q-NA--NMQTAIAEAEQ-RGEAAL-KDAKAKL----DGLEAALAKAKDDLARLLR
DYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RMS-G
ECQSS---V--------CISVVNNVSS---------------------------------
--------TSSSSGGSRGGYGGVGGS----SG--SGYRGGSSSTS---------S-----
--------------SRVSGGYG----GASG---------SSSGGYGGSSS--SG------
-GRGSSGTYQSGS----------S----------------GSRLGSG-GS--GSVSQSGI
GSSSG--GL-QTSGGGGYKS----GSGSSTNIRFS----QTT------------------
------------------------------------------------------------
----------SSS-QHCPK-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
----------------------------------------------------------MR
-SSVSGQTYST--------KGGFSSNSAGGG---GGSRART-SFSSVT-MSRSSSSGGG-
--------------------------T--------------CCGPRKGGFGSRSLYNLGG
S-KNISVSVAGGASSG-RAL----------------------------------------
--------------GGFGFG------------------SGAYA-----------------
-------GLG-------AGRQAFGP-AC--PPGGI------QEVTVNQSLLTPL----NV
EIDPEIQR--VRTQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQGQNSG--VTRNNV--EPLFE-NYLGNLRRQLDTLQS
DRGRLDSELRN-VQDVLEDFKSK-YEDEISKRTA---AENEFVLLK--K---DVDAAYLS
RMDLQGKVSTLTEELDFLNHLYEM-----ELSQVQTHVSDT----NVVLSMDNNRRLDLD
SIIA-EVKAQYELIAQ-RSRAEAEAWYQTK--YEELQVTAGKHGDNLRDTKNEIAELT--
RTVQRLQSE-M--DAVKK------------------------------------------
-----Q-CQ--QLQTAIAEAEQ-RGDMAL-KDAQKKL----GDLDVALHQAKEDLARLLR
DYQALMNVKLALDVEIATYRKLLESEE--------------------------S-RMS-G
ECPSA---V--------SISVTGNSTTVCG------------------------------
-----------------GG--------------AASFGGGMSLGVG---GG--ASKGGFS
TS----------------------------------------VGYGA----------V--
KGGPVSG--GTSILRKT--TTVKTSSRRY-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MIAKQQCVR-----G-GSRGFSCGSAI-VGG----GKRA-AFSSVS---MSGGA----
-----------------------------------------GRCS-SGGFGSRSLYNLGG
R-KSIAISMAGSRQ-SA-GFGAAGG-----------FGAGS-------------------
-------FGAGFGAGSFG----------------AGFGAGNFG-----------------
---SGFGG----SFS--GRGGPGFP-AC--PAGGI------QEVTINQSLLTPL----HV
EIDPEIQK--VRTEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWSLLQQQTATT----SSKNL--EPLFE-AYISALRKQLDTLVN
DKGRLQSELKT-TQDSVEDFKTK-YEDEINRRAA---AENDFVVLK--K---DVDAAYMN
KVELEAKVDALNDEINFLRVLFAA-----ELSQMQTHVSDT----SVVLSMDNNRDLDLD
SIIA-EVRAQYEEIAQ-KSKAEAEALYQTK--VQQLQISVDQHGDNLKSTKSEISELN--
RVIQRLRAE-I--ENVKK------------------------------------------
-----Q-CQ--TLQASVADAEQ-RGELAL-KDAYSKS----TDLKAALQKAKEELARLLR
EYQELLSVKLALDVEIATYRKLLEGEE--------------------------C-RMS-G
ERQSA---M--------CISVVGGGASAGS------------------------------
---------------VG-GG---LGS----C---SGFG--LGS-----------------
---------------------------------GFGSG--SGSGFGL--G-GG-------
----VCGSSGSKIVSTT-VTKRS--HR---------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

MTSVGVF---------SDMLSR-EKDGLVPKAKPRDVSDFSLYAPATKPCCS--------
------------------------STYKRPRLRVTVTGLA--------SRASLTTLISLS
PAMISRQQRVR-----G-GSQGFSCSSAV-IGG----GKRA-AFSSAS---MSGGA----
-----------------------------------------GRCS-SGGFGSRSLYNLGG
N-KSISISMAGCRQ-GA-GFGAAGG-----------------------------------
------------------------------------FDAGSFG-----------------
---GGFGG----SFN--GRGGASYP-VC--PAGGI------QEVTINQSLLTPL----HV
EIDPEIQK--VRTEEREQIKTLNNKFASF------IDK----------------------
-----FEQQNK-VLETKWNLLQQQTTTT----SSKNL--EPFFE-TYLSALRKQLDILVN
DKGRLQSELKT-MQDSVEDFKAK-YEDEINKRTA---AENDFVVLK--K---DVDAAYMN
KVELEAKVDALNDEINFLRVLYAA-----ELSQMQNHVSDT----SVVLSMDNNRDLDLD
SIIA-EVRAQYEEIAQ-RSKAEAEALYQTK--FQQLQISVDQYGDNLKSTKSEIAELN--
RIIQRLRAE-I--ENVKK------------------------------------------
-----Q-CQ--TLQASVADAEQ-RGP-GL-KDAFSKR----AELEAALKKAKEELTRMLR
DYQELMSVKLALDIEIATYRKLLEGEE--------------------------F-RMS-G
ECQNA---V--------SISVVGGATSAGG------------------------------
---------------IG-GG---LGS----F---SGFG--LGS-----------------
---------------------------------GFGSG--SGSGYGF--G-SG-------
----VN--SSNKIISSTTLTKRA--HRQ--------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTQKSYK--MS--TSGPRDFSSRSYTSGPA-----THV-SSSSF-------------
-------------------------------------------------------SRVGS
S----------------------G-----------SFRGG------------L-------
------------------------------------------------------------
---------------------------------GI------TAITVNQNLLSPL----KL
EVDPNIQA--VRT QEKEQIKTLHNKFASF------IDK--VR------------------
----LLEQQNK-MLETQWSLLQQ-QKT-----ARGHL--DNVFE-SYINNLRRQLDTLGQ
ETLKLEAKLGD-MQGLVEDFKNK-YEDEINQRTE---MEHEFVLLK--K---DVDEASMN
EVELESRLEG---------RLYEE-----EIRELRSQISDT----SVVPSMDSSRSLDMD
GIIA-EVRAQDEELAN-A------SRYQTK--YEELQTLAGKHGGNLRRAKTEISEMN--
RNISRLQAE-I--EGLRG------------------------------------------
-----Q-RA--SPEAAIADAEQ-RGEMAV-EDANNKL----AELEAALQRAKQDMARQLR
EDQELVIVQRALDIEIATYRKLLEGEGS---------------------------RLE-S
---GM---Q--------NMRIHTKTTSG--------------------------------
---------------YSG---------------------GLSS-----------------
---PYG------------------------------S----GLRYGF-------------
------------------------------------------GFGSGG---------GSS
TFSRT-------------------SSSRTVGVKKM------ETRDGKLVSESSDVLPSE-
--WPSQP--RP----VCPLLGLPQSLWGRWLCRE--------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSTKTTIR--SQ--TSHRGFSASSARVPG-----LNRS-GFSSVS-VCRSRGSGGSG
A-------------------------------VC-----------GGAGFGSRSLYGVGS
S-KRISIGGG----SC--GIGGG-------------YGS--RV----GGGFGFGGG----
--------------------------A------GS-----------------GF----GF
G--GG-AGFGG-GYGGAGFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPTIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWALLQEQGTK----TVRQNL--EPMFE-QYISNLRRQLDSILG
ERGRLDSELRN-MQDTVEDYKNK-YEDEINKRTA---AENEFVTLK--K---DVDAAYMN
KVELQAKADSLADEINFLRALYDA-----ELSQMQTHISDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEEIAQ-RSRAEAESWYQTK------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MNRQVCKK--SF-SGRSQGFSGRSAVVS-G-----SSR-M-SC---VARSGGA-G--
-----GG-------------------------ACGFR----SGA---GSFGSRSLYNLGS
N-KSISISVAAGSS-RAGGFGGGRS------SCG--FAGGYGGG----FGGSYGGGFGGG
--R--GVGSGFG-------------------------------GAGGFGGAGGFGGPGVF
GGPGSFGGPG--GFG----P------GG--FPGGI------QEVIVNQSLLQPL----NV
EIDPQIGQ--VKA QEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWELLQQQTTG----SGPSSL--EPCFE-SYISFLCKQLDSLLG
ERGNLEGELKS-MQDLVEDFKKK-YEDEINKRTA---AENEFVGLK--K---DVDAAFMN
KVELQAKVDSLTDEVSFLRTLYEM-----ELSQMQSHASDT----SVVLSMDNNRCLDLG
SIIA-EVRAQYEEIAQ-RSKSEAEALYQTK--LGELQTTAGRHGDDLRNTKSEIMELN--
RMIQRLRAE-I--ENVKK------------------------------------------
-----Q-NA--NLQTAIAEAEQ-RGEMAL-KDANAKL----QDLQTALQKAKDDLARLLR
DYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RMS-G
ECQSA---V--------CISVVSNVTST--------------------------------
---------SGSSGSSRGVFGGVSGS----GS--GGYKGGSSSSS---------------
--------------------SSG-YG-VSG---------GSGSGYGGVSS-GS---TG--
GR-GSSGSYQ--------------------SSSS------GSRLGGAGSIS---VSHSGM
GSSSG--SI-QTSGGSGYKS----GGGGSTSIRFS----QTT------------------
------------------------------------------------------------
----------SSS-QHSSTK----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MTQRSSV---TIKSGGSRNFSASSASLLP-----GCRP-SFSSIS-VSQGGKS----
-----------------------------------------FGGGFGGGFGTRSLHSFGG
S-KRISIS---GGY-RSG-RASLG----------------GAGY-----G--LGLGGIG-
-------YRVGGACSGYGFG----------------------------------------
----------------------GGM-MT--GAGGI------QEVTVNQSLLTPL----HL
EIDPSLQR--VRK EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWSLLQEH--KT----TRANI--EPMFE-AYISNLRRQLDSLGG
ERSRLEVELKS-MQDVVEDFKNK-YEEEINRRTV---AENEFVVLK--K---DVDAAYMS
KVELEAKVEALMDEINFLRAFYDA-----ELAQLQAQISET----SVILSMDNNRKLDLD
SIIS-EVKAQYEDIAN-RSRAEAESWYQIK--YEELQRSAGRHGDDLRSTKMEISELN--
RVIQRLRSE-I--DNLKK------------------------------------------
-----Q-CA--TLQSAIADAEQ-RGELAL-KDAKHKL----AELEDALQKAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEE--------------------------C-RWA-T
LSSYHG--S--------NGSVVSSSGGSGY------------------------------
------------SSG--------GGL----CMTGGGLSYG---------SSG--------
------------------------------------------------------------
-----------------------------------------------------------G
SFSST--SG-R--------NMS----GSSSSMRII----SKT------------------
------------------------------------------------------------
----------SS--TR-SYRS---------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--M-SRQSTIT--FQTG-SRRGFSTASATTPT-----TSRS-RFSSVS-VTRSPG--GSG
GLGKIS--------------------------GA------------GAGFGSRSLYNLGG
T-KRVSISGC-GSS-----FRSG-------------FGG--RA----SGGFGV-----S-
--------------GGFGYG--GGIGGGY-------------------------------
--------------V------------------GI------QEVTVNQSLLTPL----NL
QIDPTIQR--VRKEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWSLLQEQGTR----TVRQNL--EPLFD-AYVNDLRRQLDNVTT
ERGRLDAELRN-MQDVVEDFKVR-YEDEINKRTA---AENEFVALK--K---DVDAAYMN
KMELEAKVNSLTDEINFLQMLFEA-----ELSQMQTHVSDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEDIAN-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEISETN--
RMIQRLRAE-I--DSVKK------------------------------------------
-----Q-CA--SLQTAIADAEQ-RGELAL-KDARAKL----VDLEDALQKAKQDMARLLH
EYQELMNIKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VS-PVNIS--------VVTSTI----------------------------------
------------SSGYGAGS--GIG-----------------------------------
---------------------------------------GSSLGVSGGSG----YSFTT-
-----------------------SG-------GHSLG--T--SLGG-------------S
GFSAS---SSRGLRG------------SGSSVKFV----STTS-----------------
------------------------------------------------------------
------------SSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--M-SRQSSIT--FQSG-SRRGFSTTSATTPA-----TGRS-RFRSVS-VARSAA--GNG
GLGRIS--------------------------SA------------GASFGSRSLYNLGG
A-KRVSISGC-GSS-----FRSG-------------FGG--RA----SSGFGV-----N-
--------------SGFGYG--GGVGGGF-------------------------------
--------------SGPSFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPTIQR--VRA EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQGSR----TVRQNL--EPLFD-SYISELRRQLESITT
ERGRLEAELRN-MQDVVEDFKVR-YEDEINKRTA---AENEFVALK--K---DVDAAYMN
KVELEAKVKSLPEEINFLHSVFDA-----ELSQLQTQVSDT----SVVLSMDNSRNLDLD
SIIA-EVKAQYEDIAN-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEISEMN--
RMIQRLRAE-T--DSVKK------------------------------------------
-----Q-CS--SLQTAIADAEQ-RGELAL-KDARAKL----VDLEEALQKAKQDMARLLR
EYQELMNIKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VS-PVNIS--------VVTSTL----------------------------------
------------SSGYGSGS--GIG-----------------------------------
---------------------------------------GGSLGLGGGSG----YSFTT-
-----------------------SG-------GHSLG--A--GLGG-------------S
GFSAT---SNRGLGG------------SGSSVKFV----STTS-----------------
------------------------------------------------------------
------------SSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTQKSYK--VST--SGPRAFSSRSYTSAPG-----ARI-SSSSF-------------
-------------------------------------------------------SRVGS
G----------------------S-----------SFRGS------------LGTSM---
--------------GL---G----------------------------------------
---------------GFG-GA-G-------VG-GI------TAVTVNQSLLSPL----KL
EVDPNIQA--VRT QEKEQIKSLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQQ-QKT-----SRSNM--DNMFE-SYINNLRRQLEALGQ
EKLKLEAELGN-MQGLVEDFKTK-YEDEINKRTE---MENEFVLIK--K---DVDEAYMN
KVELESRLEGLTDEINFLRQIHEE-----EIRELQSQISDT----SVVLSMDNSRSLDMD
SIIA-EVRAQYEDIAN-RSRAEAESMYQIK--YEELQTLAGKHGDDLRRSKTEISEMN--
RNISRLQAE-I--EGLKG------------------------------------------
-----Q-KA--TLEAAIADAEQ-RGEMAI-KDANAKL----AQLETALQQAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEES---------------------------RLE-S
---GM---Q--------NLSIHTKTTSG--------------------------------
---------------YSG---------------------GLSS-----------------
---AYG------------------------------GLTSPGFSYGVSSF-------Q--
--------------------------------PS---------FSSVG---------GSS
TYSRT----------------------KAVVVKKI------ETRDGKLVSESSDILPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MNRQVCKK--SF-SGGSQGFSGRSAVVS-G-----SSR-I-SC---VARSGGV-G--
-----GG-------------------------ACGLR----SRA---GGFGSRSLYNLGG
N-KSISISVAAGGS-RAGAFVGGQS------SCG--FAGGYGGG----FGGSYGGGFGGG
--R--GIGSGFG-------------------------------GAGGFGGAGGFGGPGVF
GGLGSFGSPG--GFV----P------GG--FPGGI------QEVTVNQSLLQPL----NV
EIDPQIGQ--VKA QEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWELLQQQTTG----SGPSSL--EPCFE-SYISFLRKQLDSLLA
ERGNLEGELKS-MQDLVEDFKKK-YEDEINKRTA---AENEFVGLK--K---DVDAVFMN
KVELQAKVDSLTDEVSFLRTLYEM-----ELSQMQSHVSDR----SVVLSMDNNRCLDLD
NIIA-EVRAQYEEIAQ-RSKAEAEALYQTK--LGELQTTAGRHGDDLRNTKSEIMELN--
RMIQRLRAE-I--ENVKK------------------------------------------
-----Q-NA--NLQTAISEAEQ-RGEMAL-KDANAKI----QDLQAALQKAKDDLAQLLR
DYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RMS-G
ECQSA---V--------RISVVSNVTST--------------------------------
---------SGSSGSSRGVFGGASG------S--GGYRGSGSSS----------------
-------------------NSSG-YGGVSG---------GSSSSYRGVSS-GS---TG--
GR-GSSGGYQ--------------------SSSS------GSRLGGAGSIS---MSHRGM
GSSSG--GV-QTSGGSGYKS----GGGGSTSIHFS----QTT------------------
------------------------------------------------------------
----------SSS-QHNSNK----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
----------------------------------------------------------MR
-SSMSRQTYST--------KGGFSSNSAGGG---GGSRAHT-SFSSVT-VSRSSGSAGG-
--------------------------T--------------RCGPSKGGFGSRSLYNLGG
S-KSISVSVAGGASSG-RAL----------------------------------------
--------------GGFGFG------------------GGAYG-----------------
-------GLG-------AGRQTFGP-AC--PPGGI------QEVTVNQSLLTPL----NV
EIDPEIQR--VRTQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQGQNTG--VTRNNL--EPLFE-SYLGNLRRQLDSLQS
DRGRLDSELRN-VQDLLEDFKSK-YEDEINKRTA---AENEFVVLK--K---DVDAAYMT
RMDLHSKVGTLAEELEFLNHLYEL-----ELSQVQTHVSDT----NVILSMDNNRRLDLD
SIIA-EVKAQYELIAQ-RSRAEAEAWYQTK--YEELQVTAGKHGDNLRDTKNEIAELT--
RTVQRLQGE-V--DAVKK------------------------------------------
-----Q-CQ--QLQTAIAEAEQ-RGDLAL-KDAQKKL----GDLDTALHQAKEDLARLLR
DYQALMNVKLALDVEIATYRKLLESEE--------------------------S-RMS-G
ECPSA---V--------SISVTGNSTTVCG------------------------------
-----------------SG--------------AAGFGGGMSLGGS---GG--AGKGGFS
TS----------------------------------------VGYS-----------T--
KGGPVSG--GTSILRKT--TTVKTSSRRY-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MCG-GAGFGSRSLYGVGS
S-KRISIGGGSCGI-G-GGYGSRFG----GAY-GSRF-----G-----------------
--------------GSFGIG----GGAGSGFGFGG---------------------G---
-----------AGFGG-GYGGAGFP-VC--PPGGI------QEVTINQNLLTPL----NV
QIDPTIQW--VRT EEREQIKTLNNKFASF------IDK--VQ------------------
----FLEQQNK-VLDTKWALLQEQGTKN----QRPDL--ETLFE-QYISNLRRRLDSITG
ERGHLDSELRK-MQDTAEDYKGK-YEDEINKRTA---AENEFVTVK--K---DVDAAYMT
KVELQAKADSVADEINFLRVIFEA-----ELSQVQTVVSDT----TVVLSMDNNRSLDLD
SIIA-EVKAKYEDIVQ-RSRAEAETLYQTK--YEELQVTAGRHGDNLRNTKQEIAEIN--
RIIRRLKAE-I--DSVKK------------------------------------------
-----Q-LS--KLQAEIDDAER-RGEMAL-NDARGKM----EGMEDALQKVKQDTARMLN
EYQELMNAKLGLDVEIAAYRAILEGEE--------------------------Y-RFS-G
EG-AGP--V--------N---TSVKQQSTV------------------------------
------------SRAYGS----TGGA----SS----------------------------
---SLG--------------------------------------PGRGSS----HSYASV
--HGR------------------------------------------------------Y
GFSAG--SG-RVIR--GGLNSSVGNPST---ISS-----NHQ------------------
------------------------------------------------------------
----------SLL-WTPNSLAVMPCVQG--------HLLPASPPLLSAWV----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSCKSTVK--TQ-SISRRGFSAGSARVPG-----VCRS-GFSSVS-LSRSRGSGGLA
G-------------------------------VC-----------GGAGFGSRSLYGLGG
S-KRISIAGG----SC--VIGGG-------------YGG--RI----GVGYGFGGGA-G-
--------------SGFGFG--AG--A------GS-----------------GF----GL
G--GG-AGFGG-GFGGPGFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPTIQR--VRTEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTR----TVRQNL--EPLFE-QYINNLRRQLDSILG
ERGRLDSELRG-MQDTVEDFKNK-YEDEINKRTA---AENEFVKLK--K---DVDIAYMN
KVELQAKVDALTDEINFLRTFYDA-----ELAQMQTHISDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEEIAQ-RSRAEAESWYQSK--YEELRVTAGRHGDDLRNTKQEISEIN--
RVIQRLRSE-I--DHVKK------------------------------------------
-----Q-CA--SLQSAIADAEQ-RGELAL-KDARSKL----ADLEDALQKAKQDMARLLK
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VG-QV-------N-ISVVQSTV----------------------------------
------------SGGYGGAGGY-----------------GG--ASGL-------------
---------------------------------------GSGLGVSGGSG----YS----
-----------------------YSSG------HSLG--G--------------------
GFSSG---SGRAIG--CGFG--SSGGS-SSTIKYT----TTT-SS---------------
------------------------------------------------------------
------------SSRKGYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSV
R-V-TQKSYK--VST--SGPRAFSSRSYTSGPG-----SRI-SSSAF-------------
-------------------------------------------------------SRVGG
-----------------------------------SFRGG------------LNSSM---
--------------SV---V----------------------------------------
---------------GGYGGGAG-------GMGGI------TAVSVNQSLLSPL----KL
EVDPNIQA--VRTQEKEQIKTLNNKFASF------IDK--VR------------------
----HLEQQNK-VLETKWSLLQQ-QKT-----ARSNI--DNMFE-SYISNLRRQLDTLGQ
EKLKLEVELGN-MQGLVEDFKNK-YEEEIKERAD---MENEFVLIK--K---DVDEAYMN
KVELESRLEGLTDEINFLRQLYEE-----EIRELQSQISDT----SVVLSMDNSRSLDLD
GIIS-EVKAQYEDIAN-RSRAEAETMYQIK--YEELQTLAGKHGDDLRRTKTEISEMN--
RSISRLQAE-I--EALKN------------------------------------------
-----Q-RA--ALEAAIADAEQ-RGELAI-KDANGKV----AELEAALQRAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEES---------------------------RLE-S
---GM---Q--------NMSIHTKTTSG--------------------------------
---------------FSGECLGLGSGGQEGRRAGPFYTGGLSS-----------------
---TYG------------------------------ALPSPSLNYGLS------------
---------------------------------S--------FQSSFG---------PSG
SFSRG-------------------SSSKAVVVKKI------ETRDGKLVSESSDVLSK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
H-------------F---SSPVFTSRSAAFSGR----GAQV-RLSSA----RPGG-----
----------------------------------------------LG-S--SSLYGLG-
------------AS-RPRVAV--RS-----------------------------------
---------------AYG------------------------------------------
----------------G-------P-----VGAGI------REVTINQSLLAPL----RL
DADPSLQR--VRQ EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-LLETKWTLLQEQKSA-----KSSRL--PEVFE-AQIAGLRGQLEALQV
DGGRLEAELRS-MQDVVEDFKNK-YEDEINRRAA---AENEFVVLK--K---DVDAAYMS
KVELEAKVDALNDEINFLRTLNEM-----ELTELQSQISDT----SVVLSMDNSRSLDLD
SIIA-EVKAQYEEMAK-CSRAEAEAWYQTK--FETLQAQAGKHGDDLRNTRNEISEMN--
RAIQRLQAE-I--DNIKN------------------------------------------
-----Q-RA--KLEAAIAEAEE-RGELAL-KDARAKQ----EELEAALQRTKQDMVRQLR
EYQELMSVKLALDIEIATYRKLLEGEE--------------------------S-RLA-G
D-------G--------VGA-----VN---------------------------------
-ISVVNST-GG-----SSNG----------------GGIGLTLGG-----TMGSNALSFS
SS-----AGPGP------------------------------------------------
--------LKAYSIRTTSTSRRSARN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTQKSYK--MS--TFSPRAFSSHSNTSGPG-----TRI-SSPSF-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------SRIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-MLQTKWSLLQQ-QKT-----AHSNM--DNMFEESYINNFWQQLDTLGQ
EKLKLEAELGN-MQGLVEDFKNK-YKDEINKQME---MENEFVLIK--K---DVDEAYMN
KVELESRLEGLTVEINFLRQLYEE-----EIRELQSQILDT----SVVLSVDSSRSLDMN
GIIT-EVRTQYEEIAN-CSQAKAKSMDQTK--CKELQTLAQKHGDDLCRTKMEISEVN--
WNISRLQAE-I--EGLKG------------------------------------------
-----Q-RA--SLEAAITDAEQ-RGEMAV-KDANNKL----VKLEAALQRAKQDMTRQLR
EYQELVNIKLALDIEIATYRKLLEGEES---------------------------LLE-S
---GM---Q--------NKSIHTKTTSG--------------------------------
---------------YSG---------------------GLSS-----------------
---PYS----------------------------------SGLSYSFG------------
-------------------------------------------FGSGR---------VSS
TFNCT-------------------SSSRAVVVKKI------ETHDRKLVSESSYVPPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
H-------------F---SSPLFSSRSAGFSGR----GAQA-RLSSV----RPGG-----
----------------------------------------------XX-X--XXXXXXX-
------------XX-XXXXXX--XX-----------------------------------
---------------XXX------------------------------------------
----------------X-------X-----XXXXI------REVTINQSLLAPL----RL
DTDPSLQR--VRQ EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-LLETKWALLQEQKSA-----KSSRL--PDIFE-AQIAGLRGQLEALQV
DGGRLEAELRS-MQDVVEDFKNK-YEDEINRRTA---AENEFVVLK--K---DVDAAYMS
KVELEAKVVALSDEINFLRTLHET-----ELTELQSQISDT----SVVLSMDNSRSLDLD
GIIA-EVKAQYEEMAK-CSRAEAEAWYQTK--FETLQAQAGKHGDDLRNTRNEIAEMN--
RAIQRLQAE-I--DTIKN------------------------------------------
-----Q-RA--KLEAAIAEAEE-RGELAL-KDARAKQ----EELEAALQRAKQDMARQLR
EYQELMSVKLALDIEIATYRKLLEGEE--------------------------S-RLA-G
DGVGA---V--------NIS----------------------------------------
---VVNST-GGSG---SGSG----------------GGIGLSFGG-----TMGSNALSFS
SS-----VGPGP------------------------------------------------
--------LKAYSIRTTSTSRRSARN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--M-SRQSSIT--FQSG-SRRGFSTTSATTPA-----TGRS-RFRSVS-VARSAA--GNG
GLGRIS--------------------------SA------------GASFGSRSLYNLGG
A-KRVSISGC-GSS-----FQSG-------------FGG--RA----SSGFGV-----N-
--------------GGFGYG--GGVGGGF-------------------------------
--------------SGPSFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPTIQR--VRA EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQGSR----TVRQNL--EPLFD-SYISELRRQLESITT
ERGRLEAELRN-MQDVVEDFKVR-YEDEINKRTA---AENEFVALK--K---DVDAAYMN
KVELEAKVKSLPEEINFLHSVFDA-----ELSQLQTQVSDT----SVVLSMDNSRNLDLD
SIIA-EVKAQYEDIAN-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEISEMN--
RMIQRLRAE-I--DSVKK------------------------------------------
-----Q-CS--SLQTAIADAEQ-RGELAL-KDARAKL----VDLEEALQKAKQDMARLLR
EYQELMNIKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VS-PVNIS--------VVTSTL----------------------------------
------------SSGYGSGS--GVG-----------------------------------
---------------------------------------GGSLGLGGGSG----YSFTT-
-----------------------SG-------GHSLG--A--GLGG-------------S
GFSAT---SNRGLGG------------SGSSVKFV----STTS-----------------
------------------------------------------------------------
------------SSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTQKSYK--VS--TSGPWAFSSHSYMSGPG-----ARI-SSSSF-------------
-------------------------------------------------------SRVES
-----------------------S-----------SFRGG------------LGA-----
---------------GYA------------------------------------------
-----------------GASGM--------GMGGI------TAVTVNQSLLSPL----KL
EVDPNIQA--MHTQEKEQIETLNNKSASF------TDK--VR------------------
----FLEQQKK-MLETKWSLLQQ-QKT-----ARSNM--D-MFE-SYINNVRQQLETLGQ
EKLKLEAELGN-MKGLVEDFKNK-YDDEINKRTE---MENEFVLIK--K---DVDEAYMN
KVELASRLEGLTDEINFLRQLYEE-----AIWELQSQISDT----SVVLSMDNRRSLDTD
SIIA-EVKVQYEEITN-HSQAEAESVYQIK--YEELQMLPGKHGDDLASLETAIAE----
------------------------------------------------------------
-------------------AEH-CGEPAL-KDAHAKQ----QELETAMQRAKQDIARQLR
EYQELMNVKLALDIEITTYRKLLEGEES---------------------------RLE-S---GM---Q--------NMSIHTKTITG-----------------------------------------------YAG---------------------GQTP----------------------------------------------------------------------------------------------------------------------------------------APFSCT-------------------SSTKAMVVKKI------ETHDGRLVSESSDVLPK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ASLETAIAE-----------------------------------------------------------------------------------AEH-CGEPAL-KDAHAKQ----QELETAMQRAKQDIARQLREYQELMNVKLALDIEITTYRKLLEGEES---------------------------RLE-S
---GM---Q--------NMSIHTKTITG--------------------------------
---------------YAG---------------------GQTP-----------------
------------------------------------------------------------
-----------------------------------------------------------A
PFSCT-------------------SSTKAMVVKKI------ETHDGRLVSESSDVLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTQKSYK--VST--SEPRAFSSRFYTSGPS-----AHI-SSSM--------------
-----------------------------------------------------------G
S----------------------S-----------SFQGG------------LGRGY---
--------------G---------------------------------------------
------------------GASG---------MGGI------TTVTVNQSLLSPL----NL
EVDPNIQA--VCT QEKEQIKTLNNKFASF------IDK--IR------------------
----FLEQQNK-MLETKWSLLQQ-QKM-----AQSNM--DNMFG-SYINNLTRQLETLGQ
EKLKLEVELGN-MQGLVEDFKNK-YEDEINKLTE---MENEFVLIK--K---EVDEAYMN
KVELGSRLEGLTDEINFLRQLYEE-----EIQELQCQISDT----S--------AVL---
-IIA-EVKVQYEEITN-HSRAEAESMYQIK--YEELQTLVGKHGNDLRRTKTEISEMN--
RNISRLQAE-T--EALKG------------------------------------------
-----Q-RT--SLEAAIADAEQ-RGELAV-KDANAEL----SELEAAQERAKQDMARPLR
EYQELMNVKLALDIQIATYRKLLEGDES---------------------------RLE-S
---GM---L--------NMSIHTKTTSS--------------------------------
---------------YAG------------------------------------------
---AFG------------------------------GFTSPGLSYSLG------------
---------------------------------S--------SFGSGA---------GSS
SFSST-------------------GSTRAVVVKKI------KTRDGKLE--SSDVLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------M--
----SRQASKT--S--GGGSQGFSGRSAVVSG------SSR-M-SC---AARSGGA-G--
-----GG-------------------------AYGFR----SG---AGGFGSRSLYNLGG
N-KSISISVAAGGS-RAGGFGGGRS------S--CGFAGGYGGGFGGGYGGGFGGGFGGG
--R--GMGGGFGGAGGFG--------GAGGFGGA-----GGFGGPGGFGGPGVFGGPGSF
GSPGGF---------G---P------GG--FPGGI------QEVTINQSLLQPL----NV
EIDPQIGQ--VKA QEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQQQGTSSI--SGTNNL--EPLFE-NHINYLRSYLDNILG
ERGRLDSELKN-MEDLVEDFKKK-YEDEINKRTA---AENEFVTLK--K---DVDSAYMN
KVELQAKVDALIDEIDFLRTLYDA-----ELSQMQSHISDT----SVVLSMDNNRSLDLD
SIIA-EVRAQYEDIAQ-RSKAEAEALYQTK--LGELQTTAGRHGDDLRNTKSEIIELN--
RMIQRLRAE-I--EGVKK------------------------------------------
-----Q-NA--NLQTAIAEAEQ-HGEMAL-KDANAKL----QELQAALQQAKDDLARLLR
DYQELMNVKLALDVEIATYRKLLEGEE--------------------------Y-RMS-G
ECPSA---V--------SISVVSSST----------------------------------
--------TSASAGGYGGGYGG-------------GLGGGLGGGF---------------
--------------------SA----GGG-----------SGSGFGRGGG--GGIGG---
---GFGG------------------GS--------------------SSG--F-SGGSGF
GSISG--AR-YGVSGGGFSS----ASNRGGSIKFS----QSS------------------
------------------------------------------------------------
----------QSS-QRYSR-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTQKSYK--VST--SGPRAFSSRSYTSGPG-----ARI-SSSSF-------------
-------------------------------------------------------SRVGS
S----------------------------------SFRGG------------LGGGY---
------------------------------------------------------------
-------------------GGAS-------GMGGI------TAVTVNQSLLSPL----NL
EVDPNIQA--VRT QEKEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQQ-QKT-----ARSNM--DNMFE-SYINNLRRQLETLGQ
EKLKLEAELGN-MQGLVEDFKNK-YEDEINKRTE---MENEFVLIK--K---DVDEAYMN
KVELESRLEGLTDEINFLRQLYEE-----EIRELQSQISDT----SVVLSMDNSRSLDMD
SVIA-EVKAQYEEIAN-RSRAEAESMYQIK--YEELQSLAGKHGDDLRRTKTEISEMN--
RNISRLQAE-I--ESLKG------------------------------------------
-----Q-RA--SLEAAIADAEQ-RGELAI-KDANAKL----SELEAALQRAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEES---------------------------RLE-S
---GM---Q--------NMSIHTKTTSG--------------------------------
---------------YAG---------------------GLSS-----------------
---AYG------------------------------GLTSPGLSYGLG------------
--------------------------------SS---------FGSGA---------GSS
SFSRT-------------------SSSRAVVVKKI------ETRDGKLVSESSDVLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
----------------------------------------------------------MR
-SSVSRQTYST--------KGGFSSNSASGG---AGAGTHT-SFSSVT-VSRSSGSGGR-
--------------------------A--------------RCGPSTGGFGSRSLYNLGG
H-KSISVSVAGGASAG-RAL----------------------------------------
--------------GGFGFG------------------SRAFT-----------------
-------GLG-------AGRQTFGP-TC--PPGGI------QEVTVNQSLLTPL----NV
EIDPEIQR--VRT QEREQIKILNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQGQNLG--GTRNNL--DLLFE-AYLGNMRSVLDRLQG
ERGRLDSELRN-VQDLVEDFKNK-YEDEINKRTA---AENEFVVLK--K---DVDAAYMG
RMDLQGKMNSLTQEIDFLQQLYEM-----ELSQVQTHVSDT----NVVLSMDNNRNLDLD
SIIA-EVKAQYELIAQ-RSRAEAEAWYQTQ--YEELQVTAGKHGDNLRDTKNEIAELT--
RTIQRLQGE-V--DAAKK------------------------------------------
-----Q-CQ--QLQTAIAEAEQ-KGEMAL-KDAQKKL----ADLDVALHQAREDLARLLK
EYQELMNVKLALDVEIATYRKLLESEE--------------------------S-RMS-G
ECPSA---V--------SISVTGNSTTVRG------------------------------
-----------------GG--------------AAGFGGGISLGGS---GG--ATKGGFS
TN----------------------------------------VGYST----------I--
KGGPVSG--GTSILRKT--TTVKTSSRRY-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTQKFYK--VF--TSGTQAFSSNSYTGGPE-----VHI-SFSSF-------------
-------------------------------------------------------SQVGS
-----------------------------------SFWGG------------LGR-----
---------------GCD------------------------------------------
-----------------GASS----------MGGI------TAVTVNQSLLSPL----NL
QVDPNIQ A--MCT QEKEQIKTLNNKFASF------IDK--VW------------------
----LLEQQNK-MLETKWSVLQQ-QKM-----TLSNM--DSMLE-SYINNLQRQLETLGQ
EKLKLEEEAGS-MQGLVEGFKNK-YKGKINKHTE---MENEFVLIK--E---VVDDAYMN
KVELESCLEGLTDEINFLRQLYEE-----EIRELS-QILDT----SVVLSMDNRCSLDMD
SIIA-EVKAQYEEIAK-AESMY--Q---IK--YEELQTLAGKHGDDLCHTNMEISEMN--
WNISWLQAE-I--EGLKG------------------------------------------
-----Q-RA--SLEAAITDAEQ-HGELAV-KNANIKL----YELGPTLQWAEQDMLALDI
EIATYRKL-------------L-EGMES---------------------------WLE-L
GMQHM---Q--------NMSIHMKTTGG--------------------------------
---------------YAG---------------------GLSS-----------------
---AYG------------------------------DLTSPSLSYGLG------------
---------------------------------S--------SFGSGT---------GSI
SFSCT-------------------SSVRAMVVKRI------KTHNGKLVSKSSDVLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSYKSTVK--TQ-SISRKGFSAGSARVPG-----VCRS-GFSSVS-LSRSRGSGGLA
G-------------------------------VC-----------GGAGFGSRSLYGLGG
S-KRISIAGG----SC--AIGGG-------------YGG--RI----GVGYGFGGGV-G-
--------------SGFGFG--AG--A------GS-----------------GF----GL
G--GG-AGFGG-GFGGPGFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPTIQR--VRTEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVRQNL--EPLFE-QYINNLRRQLDSILG
ERGRLDSELRG-MQDTVEDFKNK-YEDEINKRTV---AENEFVNLK--K---DVDAAYMN
KVELQAKVDALTDEINFLRTFYDA-----ELAQMQTHISDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEEIAQ-RSRAEAESWYQSK--YEELQVTAGRHGDDLRNTKQEISEIN--
RVIQRLRSE-I--DHVKK------------------------------------------
-----Q-CA--SLQSAIADAEQ-RGELAL-KDARSKL----ADLEDALQKAKQDMARLLK
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VG-QV-------N-ISVVQSTV----------------------------------
------------SGGYGGAGGY-----------------GG--ASGL-------------
---------------------------------------GSGLGVSGGSG----YS----
-----------------------YSSG------HSLG--G--------------------
GFSSG---SGRAIG--CGFG--SSGGS-SSTIKYT----TTT-SS---------------
------------------------------------------------------------
------------SSRKGYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MIARQQCVR-----G-GPRGFSCGSAIVGGV----KRR--GFSSAS---VSGGA----
-----------------------------------------GRCS-SGGFGSRSLYNLGG
N-KSISMSVAGSRQ-GA-CFGGAG---------------GGFG-----------------
------A-------SGLGA----------------GFSAAGFG-----------------
---GGFGG----SFS--GKGGPGFS-VC--PAGGI------QEVTINQSLLTPL----HV
EIDPEIQK--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQQQTTTT----SSKNL--EPLFE-TYLSVLRKQLDTLVN
DKGRLQSELKT-MQDSVEDFKTK-YEDEIHKRTA---AENDFVVLK--K---DVDAAYMN
KVELEAKVDSLNDEINFLKVLYDA-----ELSQMQTHVSDT----SVVLSMDNNRNLDLD
SIIA-EVRAQYEEIAQ-RSKAEAEALYQTK--VQQLQVSVDQHGDNLKNTKSEIAELN--
RVIQRLRAE-I--ENIKK------------------------------------------
-----Q-CQ--TLQASVADAEQ-RGENAL-KDAHNKR----IELEAALQQAKEELARMLR
EYQELMSVKLALDIEIATYRKLLESEE--------------------------C-RMS-G
ECQSA---V--------SISVVSGSTSTGG------------------------------
---------------ISG-G---FGS-----------------------------GS---
---GFGL------------------------SSGFGSG--SGSGFGF--G-GS-------
----VSGSSSSKIISTTTLNKRAHR-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQSSVS--FR-SGGSRSFSTASAITPS-----VSRT-SFTSV---SRSGG--GGG
GFGRVS--------------------------LG-------GACGV-GGYGSRSLYNLGG
S-KRISISTS----GG--SFRNR-------------FGAG--A----GGGYGFGGGA-G-
--------------SGFGFG--GGAG--------G-----------------GF----GL
G--AGA-GFGG-GFGGPGFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPSIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVRQNL--EPLFE-QYINNLRRQLDSIVG
ERGRLDSELRN-MQDLVEDFKNK-YEDEINKRTT---AENEFVMLK--K---DVDAAYMN
KVELEARVDALMDEINFMKMFFDA-----ELSQMQTHVSDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEEIAN-RSRTEAESWYQTK--YEELQQTAGRHGDDLRNTKHEISEMN--
RMIQRLRAE-I--DNVKK------------------------------------------
-----Q-CA--NLQNAIADAEQ-RGELAL-KDARNKL----AELEEALQKAKQDMARLLR
EYQELMNTKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VG-PV-------N-ISVVTSSV----------------------------------
------------SSGYGGGS-G--------------YSG--GLGGGLGGG----L-----
-----G----GGL--------------------------GGGLG-GGSSG----SYYSS-
------------------------SSG-----GVGLG--GGLSVGG-------------S
GFSAS---SGRGLGVGFGS---GG-G-SSSSVKFV----STTS-S---------------
------------------------------------------------------------
-------------SRKSFKS----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--------MSS--KS-TIIRRGFSTSSARVPG-----VNRS-GFSSVS-VSRSRGGGVLG
G-------------------------------AC-----------GGAGFGSRSLYGLGG
S-KRISIGGG----SY--I-----------------------------------------
------------------------------------------------------------
-----------------SFP------VC--PPGGI------QEVTVNQNLLTPL----NL
QIDPTIQR--VRTEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVRQNL--EPLFE-QYINNLRMQLDSILG
ERSRLDSELRS-MQDLVEDYKNK-YEDEINKHTA---AENEFVTLK--K---DVDAAYMN
KVELQAKVDGLTDEINFLKVFYDA-----ELSQMQTHISDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEEIAQ-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEISEIN--
HMIQRLRSE-I--DHVKK------------------------------------------
-----Q-CA--NLQAAIADAEQ-RGEMAL-KDAKNKL----ADLEDALQKAKQDMARLLR
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLN-G
EG--VG-PV-------N-ISVTQSTI----------------------------------
------------SSGYGSSSV-------------------------V-------------
---------------------------------------GGGLGLDAGSG----YS----
-----------------------YSSG---------------------------------
-LSSS---SGRGIG--GGLS--SVGGS-SSTIKYT----TTSS-----------------
------------------------------------------------------------
------------SSKKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MHCQHFRLHSICGSKGYKNFSSVSACLPKN----VSRY-SVTSLS-SKRGVG-----
-----------------------------------------HGHRAQPSFSSRSAYNTGS
GIHKISVGSHHSG--------------------------GGHG-----------------
--------------CGFNY------------GFGHG-------------------S----
-------GFER-GFA-----------G-GAMNGGI------APVTVNQSLLAPL----NL
EIDPNIQR--VRREEKEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWAILQEQRT------ARSHI--EPLFE-AYIGNLRRQLDCLLG
EKSRLEGERKN-MEDIVEDFKRK-YEEEVNRRTT---AENEFVVLK--K---DVDAAFLH
KAELQTRVESQTDEVNFLRTMFEA-----EIAQLQGQISDT----SVIVSMDNNRNLDLD
GIIA-EVKAQYEEIAN-RSRAEAESWYQSK--YEELRLTAGRNGDDLRNTKNEVADLN--
RMINRLRGE-I--ETVNA------------------------------------------
-----QQRG--KLEGAITEAEE-RGEMAT-KDAKKKL----ADLEEGLQKAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEE--------------------------G-RLS-G
EGAG-S--V--------KISVVSSTVGGSH------------------------------
------------GGG--NSYHHESGM----SSGNG----------------HGCSG----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MIARQQYVR-----G-GPRGFSCGSAI-VGG----VRKA-AFSSAS---LSGGA----
-----------------------------------------GRCS-WGAAGSRSLYNLGG
N-KSISISMAGGRQ-GA-GFGAAGG-----------FGGGF-G-----------------
------AAGGFGAAGGFG----------------SGFGAGGFG-----------------
---GGFGG----SFG--GRGGAGFP-VC--PAGGI------QEVTINQSLLTPL----HV
EIDPEIQK--VRTEEREQIKLLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWKLLQQQTTTT----SVKNL--DPFFE-AYLNALRKQVDTLAN
DKGRLQSELKI-MQDSVEDYKTK-YEDEINKRTA---AENDFVVLK--K---DVDAAYMS
KVELEAKVDALNDEINFLRILYAA-----ELSQMQTQVSDT----SVVLSMDNNRNLDLD
SIIA-EVRAQYEEIAQ-RSKAEAEALYQTK--VQQLQTSVDQHGDSLRNTKNEISELN--
RLIQRLRAE-I--ENIKK------------------------------------------
-----Q-CQ--TLQGSVADAEQ-RGEVAL-KDAYSKR----TELEAALQKAKEELARVLR
EYQELMSVKLALDIEIATYRKLLEGEE--------------------------C-RMS-G
ECQSA---V--------SISVVGGAASAGG------------------------------
---------------LG-GG---LGG----S---SGFG--LGSGSCAGG---LGGGL---
---GGSS------------------------GFGLGSG--SGSGFGF--G-GG-------
----ISGSSSSKIISTTTLSKKS--FR---------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MIARQQGIR-----G-SSRGFSSGSAI-IGG----GKRV-AFSSAS---MSGGA----
-----------------------------------------GRCS-SGGFGSRSLYNLRG
S-KNISCGVAGPRQ-GA-GFGCAGG-----------YG----------------------
-------------TGSFG----------------AGFGIGGFG-----------------
---GGFGS----SFN--GRVGPGFP-VC--PAGGI------QEVTINQSLLTPL----HV
EIDPEIQK--VRT EEREQIKILNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWKLLQQQTTTT----SSRNL--DNFFE-TYISALRKQLDALAN
EKGRLQSELKM-MQDSVEDFKTK-YEDEINKRTS---AENDFVVVK--K---DVDAAYMN
KVELGAKVDGLNDEVNFLRVLYEA-----ELSQIQSHVSDT----SVVLSMDNNRDLDLD
SIIA-EVRAQYEEIAQ-RSKAEVEAWYQTK--VQQLQTSVDQHGDNLKSTKNEISELN--
RMIQRLRVE-I--ENIKK------------------------------------------
-----Q-CQ--TLQTSVADAEQ-RGELAL-KDAYSKR----TELEVALQKAKEELARMLR
EYQELLSVKLALDIEIATYRKLLEGEE--------------------------G-KAD-G
NLRDRETQA--------V---VGGSVSTGG------------------------------
---------------I---S---GG---------------------------LGIGG---
---GFGL------------------------GAGLGSG--SGSGFGF--S-GS-------
----VGGSSGGKIISTTTTLT-RRSQR---------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQSTVS--FKSG-SRRGFSAASATTPA-----AGRS-CFSSVS-MVRSSG--VHG
GLGRIS--------------------------GV------------GTGFGSRSLYNLDG
S-KRISISGA----NN--VFRSG-------------FGG--IA-----GRYGFSGGI-K-
--------------NGLGFG--AGVGSGY-------------------------------
--------------GGTGFP------VC--PPGGI------QEVTVNQSLLAPL----NL
QIDPTIQR--VRKEEREQIKSLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGMK----TVKQNL--EPLFE-TYISNLRRQLDVVKS
ERGRLDSELRN-MQDVVEDYKVK-FEDEINKRTA---AENEFVTLK--K---DVDSAYMK
KKELEVNSNNLMDEINFLQSMFEM-----ELSQMQNQISDT----SVVLSMDNNRSLDLD
SIIA-EVRAQYEDIAN-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKHEIAEMN--
RMIQRLRAE-I--DSAKK------------------------------------------
-----Q-CA--TLQTAIADAEQ-RGEMAL-KDARAKL----VDLEDALQKAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEE--------------------------C-RLS-G
EG--VA-PVNIS--------VVTSTL----------------------------------
------------SSGYGSGS--GVG-----------------------------------
---------------------------------------GTGLGLGGSTS----YSYTT-
-----------------------SG-------GHSLG--G--GLGS-------------T
GFSAS---SGRGLGG----------SGSNSSVKFI----STT------------------
------------------------------------------------------------
------------SSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------MSIHFSSRSTAYPGR----GAQV-RLSSG----RA-S-----
----------------------------------------------FGS---RSLYGLG-
------------SS-RPRVAV--RS-----------------------------------
---------------TYG------------------------------------------
----------------G-------P-----VGAGI------REITINQSLLAPL----SV
DIDPTIQQ--VRQ EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWTLLQEQKSA-----KSSQL--PRIFE-AQIAGLRQQLETLQL
DGGRLEVELRN-MQDVVEDFKNK-YEEEINRRTA---AENEFVLLK--K---DVDAAYTN
KVELEAKADSLQDEINFLKTLHET-----ELSELQSQISDT----SVVLSMDNSRSLDLD
GIIA-DVKAQYEEMAN-HSRAEAEAWYQTK--FETLQAQAGKHGDDLRNTRNEIAEMN--
RSIQRLQAE-I--DTLKN------------------------------------------
-----Q-RA--KLESSIAEAEE-QGELAI-KDAHAKQ----GELEAALQKAKQDVARQLR
EYQELLNTKLALDIEIATYRKLLEGEE--------------------------S-RLS-G
DGMGP---V--------NISV---------------------------------------
----VNS----------TGG----------------NGGKLIFGG-----TMGSNALSF-
-S-----GGPGA------------------------------------------------
--------LRAYSIKTTSTTRRGTHN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
----MNSRCVR-----G-GSRGFSCGSAVVVGG----GRKS-AFSSVS---MSGGA----
-----------------------------------------GRCS-SGGFGSRSLYSLGG
N-KSISMSMAGGRQ-GA-GFGAAGG-----------FG----------------------
-------------AGGFG----------------AGFGAGGFG-----------------
---GGFGG--------------GFP-AC--PPGGI------QEVTINQSLLTPL----HV
EIDPEIQK--VRTEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQQQTTTT----SSKNL--EPFFE-AYISALRKQLDSLVN
DKGRLQSELKA-MQDSVEDFKTK-YEDEINKRTA---AENDFVVLK--K---DVDAAYMI
KVELEAKVDALTDEINFLRALYAA-----ELAQMQTHVSDT----SVVLSMDNNRCLDLD
SIIA-EVRAQYEEIAQ-RSKAEAEALYQTK--VQQLQTSVDQHGDSLKNTKSEISELN--
RMIQRLRAE-I--ENVKK------------------------------------------
-----Q-CQ--TLQASVADAEQ-RGELAL-KDAYSKR----TELEAALQKAKEELARMLR
EYQELMSVKLALDIEIATYRKLLEGEE--------------------------C------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
H-------------L---SSQVFSSRSSAFPGR----GTQV-RLNSV----RPGG-----
----------------------------------------------FGGSS-SSLYGLG-
------------AS-RPRVAA--RS-----------------------------------
---------------SYG------------------------------------------
----------------G-------P-----VGAGI------REVTINQSLLTPL----QV
NIDPSIQQ--VRQEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-LLETKWALLQEQKST-----KRSCL--PGIFE-AQTAGLRKQLEALQL
DGGRLEVELRN-MQDVVEDFKNK-YEDEINRHTA---AENEFVVLK--K---DVDVAYMN
KVELEAKVDTLKDEINFLRTLYEE-----ELKELQSKVSDT----SVVLSMDNSRSLDLE
GIIA-EVKAQYEEIAN-RSRAEAEAWYQTK--FETLQAQAGKHGDDLRRSRNEIAELN--
RAVQRLQAE-I--DSNKN------------------------------------------
-----Q-RA--KLEAAVAEAEE-RGELAV-KDARAKL----VDLEEALQKAKQDMARQLR
EYQELMSTKLALDIEIATYRKLLEGEE--------------------------S-RMT-G
AGVGA---V--------NISV---------------------------------------
----VGS----------TGG----------------AGSWLTFGG-----TMGSDALRFS
SG-----GGPGA------------------------------------------------
--------PKAYSIRTTSAPGRCTRN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSR
QSTL----------FQTGSRRGFSMASATTLA-----TSRS-RSSVSV-AHSPVGSG---
-----G-----------------------------M----GRISGAGTSCGSLSLYNVGG
T-KRVSISGCSSFR-S-GFDGRASR-----------------------------------
-------------------E----IEVSGGFGYG--------------------------
-----------GRTGG-GYGGPGFS-VC--PPGGI------QEVTIN-SLLTPL----NL
QIDPTIQR--VRKEEREQIQTLNDKFASF------IDK--MR------------------
----FLEQQNE-VLETKWSLLQEQGTKT----VRQSL--EPIFN-TYIN-LQWQLDSVTT
KRGRLGAELRT-MQDVVEDLKVR-DEDEVNKHTA---AENEFAALK--K---DLDAPYMN
KVDLEAKVNSLTKGTNFLRVLFEA-----ELSQ-QTRVSDT----SVVLSMDNNCSLDLD
GIIA-EVKAQYEDIAN-RSRADAVSWYQTK--YEELQVTAGRPGDDLRNTKREISEMD--
RMIQRLRAE-I--DNVKM------------------------------------------
-----Q-CA--SLHTAIADTEQ-HGELAL-KDARAKL----VDLEEALQKAKQDMAQLLR
E-QELMNIKLALDMEVATYRKLLEGEE--------------------------C-KPS-G
EG-VSP--V--------NI-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--SMSSRSTMR--SQ-SISHRGFSASSARVPG-----VCRS-GFSSVS-VSRSRGSGGLG
G-------------------------------AC-----------GGAGFGSRSLYGLGG
S-KRISIGGG----SC--AISGG-------------YGG--RV----GGGFAYGGGA-A-
--------------SGFGFG--GA--A------GG-----------------GF----GL
G--GG-AGFAG-GYGGSGFP------VC--PPGGI------QEVTVNQNLLTPL----NL
QIDPTIQR--VRTEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVRQNL--EPLFE-QYINNLRRQLDSILG
ERGRLDSELRS-MQDTVEDFKNK-YEEEINKRTA---AENEFVTLK--K---DVDAAYMN
KVELQAKVDALTDEINFTRALYDA-----ELSQMQTHISDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEEIAQ-RSRAEAESWYQSK--YEELQVSAGRHGDDLRNTKQEIAEIN--
RMIQRLRSE-I--DHVKK------------------------------------------
-----Q-CT--NLQSAIADAEQ-RGEMAL-KDAKNKL----AGLEDALQKAKQDMARLLK
EYQELMNTKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VG-QV-------N-ISVVQSTV----------------------------------
------------SGGYGGAGGF-----------------GG--ASGM-------------
---------------------------------------GSGSGLGGGSG----YS----
-----------------------YGSG-----H-GLG--A--------------------
GFSSS---SGRGVG--SGFS--SSGGS-SSTIKYT----TTS--S---------------
------------------------------------------------------------
------------SSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
H-------------F---SSPVFTSRSAAFSGR----GAQV-RLSSA----RPGG-----
----------------------------------------------LG-S--SSLYGLG-
------------AS-RPRVAV--RS-----------------------------------
---------------AYG------------------------------------------
----------------G-------P-----VGAGI------REVTINQSLLAPL----RL
DADPSLQR--VRQ EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-LLETKWTLLQEQKSA-----KSSRL--PDVFE-AQIAGLRGQLEALQV
DGGRLEAELRN-MQDVVEDFKNK-YEDEINRRAA---AENEFVVLK--K---DVDAAYMS
KVELEAKVDALNDEINFLRTLNEM-----ELTELQSQISDT----SVVLSMDNGRSLDLD
SIIA-EVKAQYEEMAK-CSRAEAEAWYQTK--FETLQAQAGKHGDDLRNTRNEISEMN--
WAIQRLQAE-I--DNIKN------------------------------------------
-----Q-RA--KLEAAIAEAEE-RGELAL-KDARAKQ----EELEAALQRTKQDMVRQLR
EYQELMSVKLALDIEIATYRKLLEGEE--------------------------S-RLA-G
D-------G--------VGA-----VN---------------------------------
-ISVVNST-GG-----SSNG----------------GGIGLTLGG-----TMGSNALSFS
SS-----AGPGP------------------------------------------------
--------LKAYSIRTTSTSRRSARN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
-------------------------------MT------QRSS---VTIKSGGTRNF---
-------------------SASSASLLPGCRPG----FSSV-SVSQS----G--------
---------------------------------------KSFGGGFGGGFGTRSLHSFGG
N-KRISIGGGYRSS-R-ASFGGAAC-----------------------------------
---------------GLGVS-------GIGYRVGG-------------------------
------------AYGGYGFGGGMAP-----GAGGI------HEVTVNQSLLTPL----HL
EIDPSLQR--VRK EEKEQIKSLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWSLLQEHKTT-----RT-NL--EPMFE-AYITNLRRQLECLGG
ERGRLETELKS-MQDVVEDFKNK-YEEEIHRRTT---AENEFVVLK--K---DVDAAYMN
KVELEAKVDALMDEINFLRAFYEA-----ELAQLQAQISET----SVVLSMDNNRSLDLN
SIIA-EVKAQYEDIAN-RSRAEAESWYQTK--YEELQRSAGQHGDDLRSTKMEISELN--
RAMQRLRSE-I--DNLKK------------------------------------------
-----Q-CA--TLQASIADAEQ-RGELAL-KDAKHKL----AELEEALQKAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEE--------------------------C-RLT-G
EGVGA---V--------NISVVSSSGGTGYSGGG--------------------------
-G----LC-MSGSS-YS-------------------GGGYSGSGLCYGGGG----SGSFS
STSGR-SMSGSS------------------------------------------------
--------SSMRIVSKTSSSKKSYRS----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTQKSYK--VS--TSGPGAFSSLSYTGGPA-----SRI-SSSSV-------------
-------------------------------------------------------SRMGS
S----------------------S-----------SFQGG------------LGL-----
--------------GGYG------------------------------------------
-----------------GAGG----------------------MRVNQSLLNPL----NL
EVDPNIQA--VHI QEKKQIKNLNNKFASF------IDK--VW------------------
----FLEQQNK-MLETKWSLLQQ-QKT-----SQSNM--DSMFE-SYINNLQQQLDSLGQ
EKVKLEVELGN-TQGLVEDFKNK-FEDELNKLTE---MENEFVLIK--K---DVDEAYMN
KVELESCLEGLTDEIDFLRQLYEE-----EIRELR--------------------SLDLD
GIIT-EVKAQYEKFTN-HSRAEAKSMYQIK--YEEL--------DDPRLTKSEIPEMN--
HSIHHLQVE-V--EALKG------------------------------------------
-----Q-RA--SREASIADAGQ-RREMAI-KDANAKL----AQLEAALQKAKQDVAQQLR
KYQELMNIRVALDIEITTYRKLLEGEEN---------------------------RLE-A
---GV---Q--------NLSIHARTASG--------------------------------
---------------YAG---------------------MVSS-----------------
---PYS------------------------------------------------------
------------------------------------------------------------
----------------------------AVVVKKI------ETHDGKLVSETSDVLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--MTQKSYR--VST--SGPRAFSSRSFTSGPS-----ARS-S-SSF-------------
-------------------------------------------------------SRVSS
T----------------------------------GFRRG------------LGAGY---
--------------A---------------------------------------------
------------------GASGI-------GMGGI------TAVTINQSLLNPI----QL
DMDPNIQA--VRT QEKEQIKTLN-KFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQQ-QKT-----ARSNM--DNMFE-SYINNLRRQLETLGQ
GKLKLEAELGN-MQGLVEDFKNK-YEEEINKRTE---MENEFVLIK--K---DVDEADMN
KVELESRLEGLTDEIK-------------EIREPQSQISDT----SAVLSVDDSHSLDVD
SITA-EVKAQYEEIAN-SSRAEAESVYQSK--YEELQTQAGKHGDDLRRTKTEISELS--
RNISRLQAE-I--EGLKG------------------------------------------
-----Q-RA--SLEAAIADAEQ-RRELAL-RDARAKQ----EELEEALQQAKQDMARQLR
DYQELMNIKLALDIEIATYRKLLESEES---------------------------RLE-S
---GM---Q--------NMSIHTKTTSG--------------------------------
---------------YAD---------------------ALRS-----------------
---AYG------------------------------GLTSPGLSYSLG------------
---------------------------------S--------SFGSGG---------GS-
TFSRT-------------------SSTKAVVVKKI------ETRDGRLVSESSDVLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--M-SRQSTIT--FQTS-SRRGFSTASATTPA-----TSRS-RFSSAS-VTHSPA--GSG
GLGRIS------------------------------------------GFGSRSLYNLGG
T-KRVSISGC-GSN-----FRSG-------------FGG--RA----SSGFGV-----S-
--------------GGFGYG--GGIGGGH-------------------------------
--------------GGCGFS------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPNIQR--VRKEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWSLLQEQGTR----TVRQSL--EPFFE-AYITDLRRQLDSITT
ERGRLDAELRT-MQDVVEDFKVR-YEDEINKRTA---AENEFVALK--K---DVDAAYLN
KVDLEAKANSLTDEINFLQMLFEA-----ELCQMQTRVSDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEEIAN-RSRAEAESWYQTK--YEELQVTAGQHGDDLRNTKQEISETN--
RMIQRLRAE-I--DNVKK------------------------------------------
-----Q-CA--SLQTAIADAEQ-RGELAL-KDARAKL----VDLEEALQKSKQDMARLLR
EYQELMNIKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VS-PVNIS--------VVTSTV----------------------------------
------------SSGYGGGS--SIG-----------------------------------
---------------------------------------SGSLGLSGGSG----CSFMT-
-----------------------SG-------GHSL--------GG-------------S
SFSNS---SSRGLGG------------SGSSFKFV----STTS-----------------
------------------------------------------------------------
------------SSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTQKSYK--VST--SGPRAFSSRSYTSAPG-----ARI-SSSSF-------------
-------------------------------------------------------SRVGS
G----------------------S-----------SFRGS------------LGTSM---
--------------GL---G----------------------------------------
---------------GFG-GA-G-------VG-GI------TAVTVNQSLLSPL----KL
EVDPNIQA--VRT QEKEQIKSLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQQ-QKT-----SRSNM--DNMFE-SYINNLRRQLEALGQ
EKLKLEAELGN-MQGLVEDFKTK-YEDEINKRTE---MENEFVLIK--K---DVDEAYMN
KVELESRLEGLTDEINFLRQIHEE-----EIRELQSQISDT----SVVLSMDNSRSLDMD
SIIA-EVRAQYEDIAN-RSRAEAESMYQIK--YEELQTLAGKHGDDLRRSKTEISEMN--
RNISRLQAE-I--EGLKG------------------------------------------
-----Q-KA--TLEAAIADAEQ-RGEMAI-KDANAKL----AQLETALQQAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEES---------------------------RLE-S
---GM---Q--------NLSIHTKTTSG--------------------------------
---------------YSG---------------------GLSS-----------------
---AYG------------------------------GLTSPGFSYGVSSF-------Q--
--------------------------------PS---------FSSVG---------GSS
TYSRT----------------------KAVVVKKI------ETRDGKLVSESSDILPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQSSIT--FQTS-SRRGFTSASATTPA-----AGRS-RFSSVS-VAHTSG--GSR
GLGRIS--------------------------GA------------GAGFGSRSLYNLAG
T-KRISIGGC----SS--NFQSG-------------FGS--RA----SNGFGFGSGV-S-
--------------SGFGYG--GGAGGGF-------------------------------
--------------GSTGFP------IC--SSGGI------QEVTINQSLLTPL----NL
QIDPIIQQ--VRKEEWEQIKTLNNKFASF------IDK--VR------------------
----FLEEQNK-VLETKWNLLQEQGSR----TVRQNL--ESLFE-AYLNGLRSQVENTTI
KKDKLDTEMRK-VQDIMEDVKVR-YEDEINRHTA---AENELVALK--K---DVDASCMN
KVELEAKFNALTEEISFFHMLYET-----ELSHMQTQVSDT----SVVLSMDNNRCLDLD
SIIA-EVKAQYKDIAQ-RSRAEAESWYQTK--YEELQVTAGRHSNDLHNTKHEISEMN--
RTIQTLRAE-I--GSIKK------------------------------------------
-----Q-CS--NLQTAITDAEQ-CGELAL-KDARAKL----VGLEEALQKAKQDMACLLH
EYQELMTIKLALEVEIVT-HKLLEGEE--------------------------C-RLN-G
ES--VS-SINIYPI----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQVYKT--S--GGRSQGFSGHSAVVSG------SSK-M-SS---VARSRGA-S--
-----GG-------------------------AYGFR----SA---AGGFGSHSLYNLGG
N-KSISISVAAGGS-RAGGFGGRR-------ISGG----GYGGSFGGGYGGG----FGGG
RG----VGGSFGGAGGFG--------------GA-----GGFGGGGGFGGPGGFGGPSGF
GGDGGFG--------G---AGGFGP-GG--FPGGI------QEVTVNQSLLQPL----NV
EIDPQIGQ--VKAQEREQIKTLNNKFASF------IDK--VR------------------
----FLQQN---KVETKWSLLQQGTNI-T--TY---L---ELFX-XXXXXXXXXXXXXXX
XXXXXXXXXXX-XXXXXXXXXXX-XXXXXXXXXX---XXXXXXXXX--X---XVDAAYMN
KVELQTKVDAID--QIFMRTIYDE-----ELSQMQSHVSDT----SVVLSMDNNRCLDLD
GIIA-EVKAQYEDIAQ-RSKAEAEALYQMK--LGELQTTAGRHGDDLRNTKSEISELN--
RLIQRLRAE-I--EHVKK------------------------------------------
-----Q-NT--NLQVAVAEAEQ-RGELAL-KDANAKL----QDLQAALQQAKDDLARLLC
DYQELMNVKLALDVEIATYRKLLEGEE--------------------------CSRMS-G
ECQSA---V--------SISVVSNGSA---------------------------------
--------TSASAGGFGGGSYSGG------------FGMGGGA-----------------
--------------------GG----GLGR---------GGGSGFGGGS----TF-----
---------GGGS-----------------------------GLGGGSVF--GGGG--GF
GSVSG--GR-SRISGGGFSS----GSNRGSSITFS----SSQ------------------
------------------------------------------------------------
----------RNS-R---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQACKK--SF-SSGSQGFSGRSAVVS-G-----SSR-M-SC---VTRSRGA-S--
-----GG-------------------------ACGFR----SGA---GGFGSRSLYNLGG
N-KSISISVAAGGS-RAGGFGGGRS------SYG----SGFGGG----YGVG----FGGG
--R--GVGGGFG-------------------------------RAGGFGGA---------
---GGFGGAG--GFGG---PGGFGP-GG--FPGGI------QEVTINQSLLQPL----NV
EIDPQIGQ--GKAQERKQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQQQTTGSG--SGPNNL--EPFFE-SYISYLRRQLDLLLG
ERGNLDGELKN-VQDLVGDFKKK-YEDEINKRTV---AENEFVGLK--K---EVDTAYMN
KVDLQTRVDSLMDELNFLRTLYEM-----ELSQVQSHVSDT----SVVLSMDNNRCLDLD
SIIA-EVKAQYEEIAQ-KSTAEAEALYQIK--LGELQTTAGRHGDDLRSTKSEILELN--
RMIQRLRAE-I--ENVKK------------------------------------------
-----Q-NA--NLQAAIAEAEQ-RGELTV-KDANAKL----QSLQAALQQAKDDLARLLR
EHQELMNVKLALDVEIATYKKLLEGEE--------------------------C-RMS-G
ECQSA---V--------SISVVNSVTSI--------------------------------
---------SSRLSQS-----G--------------------------------------
------------------------------------------------------------
-----------------------------------------------------------I
GSSSG--ST-QTSGGSGCRP----GSGGSMSVRFS----QTS------------------
------------------------------------------------------------
----------SSS-----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------M-SS---VARSGGA-S--
-----GG-------------------------ACGFR----GG---AGGFGSRSLYNLGG
S-KSISISVAAGGS-RAGGFGGRSS---------CGFGGSYGGGFGGGSG--MGGGFGGA
GGF--GGAGGFGGAGGFG--------GAGGFGGA-----GGFGGAGGFGGAGGFGGAGGF
GGPSGFGGPG--GFGG---PGGFGP-GG--FPGGI------QEVTVNQSLLQPL----NV
EIDPQIGQ--VKTQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWSLLQQQGTNSI--TGTNNL--EPLFE-NHINYLRSYLDGILG
ERGRLDSELRN-MQDLVEDFKKK-YEDEINKRTV---AENEFVTLK--K---DVDTAYMN
KLELQAKVDALVDEINFLRTLYD------ELSQMQSHVSDT----SVVLSMDNNRSLDLD
SIIT-EVRAQYEDIAQ-RSKAEAEALYQTK--LGELQTTAGRHGDDLRSTKSEIVELN--
RMIQRLRAE-I--ENVKK------------------------------------------
-----Q-NA--NLQTAIVEAEQ-RGELAL-KDANTKL----QELQTALQHAKDDLARLLR
DYQELMNVKLALDVEIATYRKLLEGEE--------------------------YREAP--
------------------------------------------------------------
---------SSEAFGSGGGFGG-------------GFGMGSA------------------
----------------------------------------AGSGFARGGG--GGIGGG--
SGFSGS------------------------------------------SG--F-SSGSGF
GSGSG--GR-YGVSGGGFSS----VSSRGGSIKFS----QSS------------------
------------------------------------------------------------
----------QSS-QRYSR-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSL
H-------------F---GSQVFSSRSAAFPGR----GTQV-RLSSV----RPGG-----
----------------------------------------------FGSS--SSLYGLG-
------------AS-RPRVAA--RS-----------------------------------
---------------SYG------------------------------------------
----------------A-------P-----VGTGI------RAVTINQSLLTPL----QV
DIDPSIQQ--VRQEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-LLETKWALLQEQKSA-----KSNRL--PGIFE-AQIAGLRKQLEALQL
DGGRLEVELRN-MQDVVEDFKNK-YEDEINHRTA---AENEFVVLK--K---DVDVAYMN
KVELEAKVDTLNDEINFLRTLYEQ-----ELKELQSEVSDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEEIAN-RSRAEAEACYQTK--FETLQAQAGKHGDDLQNTRNEIADMN--
RAVQRLQAE-I--DSVKN------------------------------------------
-----Q-RS--KLEAAIADAEQ-RGELAV-KDARAKQ----EDLEAALQKAKQDMTRQLR
EYQELMNVKLALDIEIATYRKLLEGEE--------------------------S-RLT-G
DGVGA---V--------NISV---------------------------------------
----VSS----------TGG----------------SGSLLTFGG-----TMGNNALRFS
SG-----GGPGT------------------------------------------------
--------LKAYSMRTTSATSRSPRK----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------AAMS--
--------------R----SVSFSSRSVAVP-G----VSQM-RVSTV-------------
-----------------------------------SSTRGGVG----AGFGSSSLYNLGS
TNKRISLGGG--------SSYSVRS-----------------------------------
---------------GYGYG-------GM-------------------------------
------------GF------GGGVP-------GGI------QEVTINQSLLTPL----NL
EIDPNIQR--VRKEEKEQIKTLNNRFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQDQKAA-----RS-NI--APMFE-AYINNLRRQLDGLLN
DKGRLEGELKN-MQDLVEDFKSK-YEDEINKRTA---AENEFVVLK--K---DVDAAYMN
KVELEAKVDALTDEINFLRSLYEA-----ELRELQSQISDT----SVVLSMDNSRNLDLD
SIIA-EVKAQYEDIAN-RSRAEAESWYQSK--YEALQVTAGKHGDDLRNTKNEISEIN--
RMIQRLQGE-I--ENAKA------------------------------------------
-----Q-RA--KLEAAIAEAEE-RGEMAV-RDAKAKL----EELEAALQKAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEE--------------------------S-RLA-G
DGVGS---V--------NISVVSSSGGGGYSSSS--------------------------
-G----FL-G----------------------------GGVRGGLNLGAGM-GSGALGFS
S-------G-GA------------------------------------------------
--------TKSYTVTTTSS-TRSFRK----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MST
KTTIR---------SQT-SHRGFSASSARVPG-----LNRS-GFSSVS-VCRSRGSG---
-----G-----------------------------S----GAVCG-GAGFGSRSLYGVGS
S-KRISIGGGSCGI-G-GGYGSRVG-----------------------------------
--------------GGFGFG----GGAGSGFGFGG---------------------G---
-----------AGFGG-GYGGAGFP-VC--PPGGI------QEVT------VPL----NL
QIDPTIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWALLQEQGTKT----VRQNL--EPMFE-QYISNLRRQLDSILG
ERGRLDSELRN-MQDTVEDYKNK-YEDEINKRTA---AENEFVTLK--K---DVDAAYMN
KVELQAKADSLADEINFLRALYDA-----ELSQMQTHISDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEEIAQ-RSRAEAESWYQTK--L---------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------N-G
EG-VGP--V--------N---ISV-VQSTV------------------------------
------------SSGYGS----AGGA----SS----------------------------
---SLG--------------------------------------LGGGSS----YSYSSW
--LGPG-----------------------------------------------------G
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQSSVS--FR-SGGSRSFSTASAITPS-----VSRT-SFTSV---SRSGG--GGG
GFGRVS--------------------------LG-------GACGV-GGYGSRSLYNLGG
S-KRISISTS----GG--SFRNR-------------FGAG--A----GGGYGFGGGA-G-
--------------SGFGFG--GGAG--------G-----------------GF----GL
G--GGA-GFGG-GFGGPGFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPSIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVRQNL--EPLFE-QYINNLRRQLDSIVG
ERGRLDSELRN-MQDLVEDFKNK-YEDEINKRTT---AENEFVMLK--K---DVDAAYMN
KVELEARVDALMDEINFMKMFFDA-----ELSQMQTHVSDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEEIAN-RSRTEAESWYQTK--YEELQQTAGRHGDDLRNTKHEISEMN--
RMIQRLRAE-I--DNVKK------------------------------------------
-----Q-CA--NLQNAIADAEQ-RGELAL-KDARNKL----AELEEALQKAKQDMARLLR
EYQELMNTKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VG-PV-------N-ISVVTSSV----------------------------------
------------SSGYGGGS-G--------------YGG--GLGGGLGGG----L-----
-----S----GGL--------------------------GGGLG-GGSSG----SYYSS-
------------------------SSG-----GVGLG--GGLSVGG-------------S
GFSAS---SGRGLGVGFGS---GG-G-SSSSVKFV----STTS-S---------------
------------------------------------------------------------
-------------SRKSFKS----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---------------------------------------RI-SSS-S-------------
-------------------------------------------------------SRVSS
---------------------------------------S------------FGLGG---
------------------------------------------------------------
-------------------YGGS-------GMGGI------TAVTVNQSLSPV------L
EVDPNI-A--VRTQEKEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQQ-QKT-----ARSNM--DNMFE-SYINNLRRQLETLGQ
EKLKLEAELGN-MQGLVEDFKNK-YEDEINKRTE---MENEFVLIK--K---DVDEAYMN
KVELESRLEGLTDEINFLRQLYEE-----EIRELQSQISDT----SVVLSMDNSRSLDMD
SIIA-EVKAQYEDIAN-RSRAEAESMYQIK--YEELQSLAGKHGDDLRRTKTEISEMN--
RNISRLQAE-I--EGLKG------------------------------------------
-----Q-RA--SLEAAIADAEQ-RGELAI-KDANAKL----SELEAALQRAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEES---------------------------RLE-S
---GM---Q--------NMSIHTKTTSG--------------------------------
---------------YAG---------------------GLSS-----------------
---AYG------------------------------GLTSPGLSYGLG------------
--------------------------------SS---------FGSGA---------GSS
SFSRT-------------------SSSRAVVVKKI------ETRDGKLVSESSDLLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

-----------------------------------------------------MNGVSWS
------------------------------------QDLQEGISAWFGPPASTPASTMSI
R--VTQKSYK--VST--SGPRAFSSRSYTSGPG-----SRI-SSSSF-------------
-------------------------------------------------------SRVGS
S----------------------------------NFRGG------------LGGGY---
------------------------------------------------------------
-------------------GGAS-------GMGGI------TAVTVNQSLLSPL----VL
EVDPNIQA--VRT QEKEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQQ-QKT-----ARSNM--DNMFE-SYINNLRRQLETLGQ
EKLKLEAELGN-MQGLVEDFKNK-YEDEINKRTE---MENEFVLIK--K---DVDEAYMN
KVELESRLEGLTDEINFLRQLYEE-----EIRELQSQISDT----SVVLSMDNSRSLDMD
SIIA-EVKAQYEDIAN-RSRAEAESMYQIK--YEELQSLAGKHGDDLRRTKTEISEMN--
RNISRLQAE-I--EGLKG------------------------------------------
-----Q-RA--SLEAAIADAEQ-RGELAI-KDANAKL----SELEAALQRAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEES---------------------------RLE-S
---GM---Q--------NMSIHTKTTSG--------------------------------
---------------YAG---------------------GLSS-----------------
---AYG------------------------------GLTSPGLSYSLG------------
--------------------------------SS---------FGSGA---------GSS
SFSRT-------------------SSSRAVVVKKI------ETRDGKLVSESSDVLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTQKSYK--VST--SGPRAFSSRSYTSGPG-----SRI-SSSSF-------------
-------------------------------------------------------SRVGS
S----------------------------------NFRGG------------LGGGY---
------------------------------------------------------------
-------------------GGAS-------GMGGI------TAVTVNQSLLSPL----VL
EVDPNIQA--VRT QEKEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQQ-QKT-----ARSNM--DNMFE-SYINNLRRQLETLGQ
EKLKLEAELGN-MQGLVEDFKNK-YEDEINKRTE---MENEFVLIK--K---DVDEAYMN
KVELESRLEGLTDEINFLRQLYEE-----EIRELQSQISDT----SVVLSMDNSRSLDMD
SIIA-EVKAQYEDIAN-RSRAEAESMYQIK--YEELQSLAGKHGDDLRRTKTEISEMN--
RNISRLQAE-I--EGLKG------------------------------------------
-----Q-RA--SLEAAIADAEQ-RGELAI-KDANAKL----SELEAALQRAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEES---------------------------RLE-S
---GM---Q--------NMSIHTKTTSG--------------------------------
---------------YAG---------------------GLSS-----------------
---AYG------------------------------GLTSPGLSYGLG------------
--------------------------------SS---------FGSGA---------GSS
SFSRT-------------------SSSRAVVVKKI------ETRDGKLVSESSDVLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSS
KTTVR---------SQNSSRRGFSASSARVPG-----LSRS-GFSSVS-VCRSRGSG---
-----G-----------------------------I----GAAYG-GAGFGSRSLYGLGG
S-KRISIVGGSCAA-G-GAYGTRVG-----------------------------------
--------------GGFSYG----GGACSGFGFGG---------------------GAGF
GG--------GAGFVG-GYGGAGFP-VC--PPGGI------QEVTVNQSLLTPL----NL
EVDPTIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWALLQEQGTKT----VRNNV--EPLYE-QYISNLRRKLDFHVG
ERGRLDTELRS-MQGTVEDYKNK-YEDEINKRTA---AENEFVTLK--K---DVDAAYMN
KTELQARADSLIDEINFLRVLYDA-----ELSQMQTHISDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEEIAQ-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEIAEIN--
RMIQRLRSE-I--DHVKK------------------------------------------
-----Q-VQ--KTESVRAH-----------------------------------------
------------FYAFEAFALFF-------------------------------------
---------------------DGMKAQSTV------------------------------
------------SSGYGS----GSNM----GS----------------------------
---GMG--------------------------------------LGGGSG----YSYSSG
--HNLG-----------------------------------------------------G
GFSSG--SG-RGISLGGGLSSVGGSSSS---I-KY----TSS------------------
------------------------------------------------------------
----------SSS-RKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------M--
----SRQASKT--S--GGGSQGFSGRSAVVSG------SSR-M-SC---VARSGGA-G--
-----GG-------------------------AYGFR----SG---AGGFGSRSLYNLGG
N-KSISISVAAGGS-RAGGFGGGRS------S--CGFAGGYGGGFGGGYGG----GFGGG
--R--GMGGGFGGAGGSG--------GAGGFGGA-----GGFGGPGG------FGGPGSF
GSPGGF---------G---P------GG--FPGGI------QEVTINQSLLQPL----NV
EIDPQIGQ--VKAQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQQQGTSSI--SGTNNL--EPLFE-NHINYLRSYLDNILG
ERGHLDSELKN-MEDLVEDFKKK-YEDEINKHTA---AENEFVTLK--K---DVDSAYMN
KVELQAKVDALIDEIDFLRTLYDA-----ELSQMQSHISDT----SVVLSMDNNRSLDLD
SIIA-EVRAQYEDIAQ-RSKAEAEALYQTK--LGELQTTAGRHGDDLRNTKSEIIELN--
RMIQRLRAE-I--ESVKK------------------------------------------
-----Q-NA--NLQTAIAEAEQ-HGEMAL-KDANAKL----QELQAALQQAKDDLARLLR
DYQELMNVKLALDVEIATYRKLLEGEE--------------------------YSRMS-G
ECPSA---V--------SISVVSSST----------------------------------
--------TSASAGGYGGGYGG-------------GLGGGLGGGF---------------
--------------------GA----GGG-----------SGSGFGRGGG--GGIGG---
---GFGG------------------GS--------------------SSG--F-SGGSGF
GSISG--AR-YGVSGGGFSS----ASNRGGSIKFS----QSS------------------
------------------------------------------------------------
----------QSS-QRYSR-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--M-SRQSTIT--FH-SGSRRGFSTASATTPT-----AGRS-RFSSVS-VARSSG--NSG
GLGRIS--------------------------GI------------GSGFGSRSLYNLGG
T-RRVSIGGCTGSG-----FRGG-------------FGG--RA----SSGFGG-----S-
--------------SGFAYG--GGIGGGF-------------------------------
--------------GGPGFP------VC--PSGGI------QEVTVNQSLLTPL----NL
QIDPTIQR--VRK EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQEQGSR----TVRQNL--EPFFD-AYVNDLRRQLDGITA
ERGRLDAELRN-MQEVVEDFKVR-YEDEINKRAA---AENEFVGLK--K---DVDSAYMN
KVELEAKVDSLTDQINFYRMIYEA-----ELSQMQNQVSDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEDIAN-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEISEMN--
RMIQRLRSE-I--DAVKK------------------------------------------
-----Q-CS--SLQTAISDAEQ-RGELAL-KDARAKL----MELEDALQKAKQDMARLLR
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VS-PVNIS--------VVTSTV----------------------------------
------------SSGYGGGA--NIG-----------------------------------
---------------------------------------GGSLGLGGNSG----YSFTT-
-----------------------SG-------GHSLG--T--GLGG-------------S
GFTTN---SSRGPVG------------SGSSIKFV----SSTS-----------------
------------------------------------------------------------
-------------SRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQSSVT--FQTG-NRRGFSAASAITPA-----TGGS-RFSSVS-VAHSLG--GNG
GVGRIS--------------------------GS------------GVGFGSRSLYNLGG
P-KRALASGC----SS--SFRNG-------------FGS--RA----GGGFGFGSGF-S-
--------------SGFGYG--SGAGGSY-------------------------------
--------------GGPGFP------TC--PSGGI------QEVTINQSLLTPL----NL
QIDPTIQR--VRKEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKW-LLQEQGSR----SVKHNL--ESLFD-VYINELRRNLDSLVS
ERGRLDGELRN-MQDVVEDFKVR-Y-DEINKRTA---SENEFVALK--K---DVDGAFMN
KVELEAKVNSLTDEINFFRMFYEA-----ELAQMQTQVSDT----SVVLSMDNSRTLDLD
SIIA-EVKAQYEDIAN-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTXXXXXXXX--
XXXXXXXXX-X--XXXXX------------------------------------------
-----X-CA--NLQTAIADAEQ-RGELAL-KDARAKL----VELEDALQKAKQDMARLLR
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VS-PVNIS--------VVTNTV----------------------------------
------------SSGYGSGG--GLG-----------------------------------
---------------------------------------GGNLGLGGSSG----YSFTT-
-----------------------SG-------GHSLG--S--GLGG-------------P
GLSAC---SGRALGG------------LGSSVKFV----STTS-----------------
------------------------------------------------------------
------------SSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
-------------------------------MT------QRSS---VTIKSGGTRNF---
-------------------TASSASMLPGCRPG----FSSV-SMSQS----G--------
---------------------------------------KSFGGSFGGGLGTRSLHSFGG
N-KRISISGGYRSS-Q-ASFGGAAC-----------------------------------
---------------GLGVG-------GIGYRVGG-------------------------
------------AYGGYGFGGGTAP-----GAGGI------HEVTVNQSLLTPL----HL
EIDPSLQR--VRK EEKEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWSLLQDHKTT-----RT-NL--EPMFE-SYIANLRRQLECLGG
ERGRLETELKS-MQDVVEDFKNK-YEEEIHKRTT---AENEFVVLK--K---DVDAAYMN
KVELEAKVDALMDEINFLRAFYEA-----ELAQLQAQISET----SVVLSMDNNRSLDLN
SIIA-EVKAQYEDIAN-RSRAEAESWYQTK--YEELQRSAGQHGDDLRTTKMEISELN--
RAMQRLRSE-I--DNLKK------------------------------------------
-----Q-CA--TLQASIADAEQ-RGELAL-KDAKHKL----AELEEALQKAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEE--------------------------C-RLT-G
EGVGA---V--------NISVVSSSGGTGYSGGG--------------------------
-G----LC-MSGGS-YS-------------------RGGYSSSGHCYGGGG----SGGFS
STSGR-SVSGSS------------------------------------------------
--------SSMRIISKTSSSKTSYRS----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

-----------------------------------------------------MNGVNWS
------------------------------------QDLQEGISSWFGPPASTPASTMSI
R--VTQKSYK--VST--SGPRAFSSRSYTSGPG-----ARI-SSSSF-------------
-------------------------------------------------------SRVGS
S----------------------------------SFRGG------------LGGGY---
------------------------------------------------------------
-------------------GGAS-------GMGGI------TAVTVNQSLLSPL----NL
EVDPNIQA--VRT QEKEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQQ-QKT-----ARSNM--DNMFE-SYINNLRRQLETLGQ
EKLKLEAELGN-MQGLVEDFKNK-YEDEINKRTE---MENEFVLIK--K---DVDEAYMN
KVELESRLEGLTDEINFLRQLYEE-----EIRELQSQISDT----SVVLSMDNSRSLDMD
SIIA-EVKAQYEEIAN-RSRAEAESMYQIK--YEELQSLAGKHGDDLRRTKTEISEMN--
RNISRLQAE-I--EGLKG------------------------------------------
-----Q-RA--SLEAAIADAEQ-RGELAI-KDANAKL----SELEAALQRAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEES---------------------------RLE-S
---GM---Q--------NMSIHTKTTSG--------------------------------
---------------YAG---------------------GLSS-----------------
---AYG------------------------------GLTSPGLSYGLG------------
--------------------------------SS---------FGSGA---------GSS
SFSRT-------------------SSSRAVVVKKI------ETRDGKLVSESSDVLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MNRQVCKK--SF-SGGSQGFSGRSAVVS-G-----SSR-M-SC---VARSGGA-G--
-----GG-------------------------ACGFW----SRA---GGFGSCSLYNLGG
N-KSISISVAAGGS-RAGGFGGGRS------SCG--FAGGYGGG----FGGSYGGGFGGG
--R--GVGSGFG-------------------------------GAGGFGGASGFGGPGVF
GGPGSFGGPG--GFG----P------GG--FPGGI------QEVTINQSLLQPL----NV
EIDPQIGQ--VKAQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWELLQQQTTG----SGPSSL--EPYFE-SYISFLRKQLDSLLG
ERGNLEGELKS-MQDLVEDFKKK-YEDEINKRTV---AENEFVGLK--K---DVDVAFMN
KVELQAKVDSLTDEVSFLRTLYEM-----ELSQMQSHVSDT----SVVLSMDNNRCLDLD
SIIA-EVRAQYEEIAQ-RSKAEAEALYQTK--LGELQTTAGRHGDDLRNTKSELMEVN--
RMIQRLRAE-I--ENVKK------------------------------------------
-----Q-NA--NLQTAIAEAEQ-RGEMAL-KDANAKL----QDLQAALQKAKDDLARLLR
DYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RMS-G
ECQSA---V--------CISVVSNVTST--------------------------------
---------SGSSGSSRGVFGGVSGS----GS--GGYKGGSSSSS---------------
--------------------SSG-YGGVSG---------GSSSGYGGVSS-GS---TG--
GR-GSSGGYQ--------------------SSSN------GSRLGGAGSIS---VGHSGM
GSSSG--SI-QTSGGSGYKS----GGGGSTSIRFS----QTT------------------
------------------------------------------------------------
----------SSS-QHSSTK----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MNRQVCKK--SF-SGESQGFSGRSAVVS-S-----SSR-M-SC---VARSGGA-G--
-----GG-------------------------ACGFR----SGA---GGFGSRSLYNLGG
N-KSISISVAAGSS-RAGGFGAGHS------TCG--FG-GYGSG----FGGIYGGGFGSG
--R--GVGSGFG-------------------------------GAGG------F------
GGAGGFGGPG--SFGG---PGGFGP-GG--FPGGI------QEVTVNQSLLQPL----NV
EIDPQIGQ--VKA QEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWELLQQQTTGSG--SGPRSL--EPYFE-SYISFLRKQLDSLLG
EKGNLEGELKN-MQDLVEDFKKK-YEDEINKRTA---AENEFVGLK--K---DVDAAFMN
KVELQAKVDSLTDEVSFLRTLYEM-----ELSQMQSHVSDT----SVVLSMDNNRCLDLD
SIIA-EVRAQYEEIAQ-RSKAEAEALYQTK--LGELQTTAGRHGDDLRNTKSEITELN--
RMIQRLRAE-I--ENVKK------------------------------------------
-----Q-NA--NLQMAIAEAEQ-RGEMAL-KDANAKL----QDLQAALQKAKDDLARLLR
DYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RMS-G
ECPSA---V--------CISVVSNVTST--------------------------------
---------SGSSGSSRGIFGGVSG------S--GGYRGGSRSS----------------
-------------------SSSS-GYGVSG---------GGSSG-YGGVS-SG---SA--
GGRGSSGGYQ--------------------SSSS------GSRLGGAGSIS---GSHSGM
GSSSG--SV-QTSGGSGYKS----GGGGSTNLRFS----QTT------------------
------------------------------------------------------------
----------SSS-QHSSTK----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
----------------------------------------------------------MR
-SSVSRRTYAT--------KGGFSSNSASGG---GGSRTHT-SFSSVA-VSRSSGSSGG-
--------------------------TRGCGV---------RGGPSTCGFGSRSLYNLGG
S-KSISVSMAGGASSG-RAL----------------------------------------
--------------GGF--G------------------GGAFA-----------------
-------GLG-------AGRQMFGP-AC--PPGGI------QEVTINQSLLTPL----NV
EIDPEIQR--VRTQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQGQNSG--VTRNNL--EPLFE-TYLSNLRRQLDGFQS
ERGRLDSELRS-VQDLVEDFKSK-YEDEINKRTA---AENEFVVLK--K---DVDAAYMG
RMDLHGRVDNLTQEIGFLQQLYEM-----ELGQVQTHVSDT----NVVLSMDNNRSLDLD
SIIA-EVKAQYELIAQ-KSRAEAETWYQTK--YEELQVTAGKHGDNLRDTKNEIAELT--
RTVQRLQGE-V--DAARK------------------------------------------
-----Q-CQ--QLQTGIAEAEQ-RGDLAL-KDAQKKL----GDLDVALHQAKEDLARLLR
DYQALMNVKLALDVEIATYRTLLEGEE--------------------------S-RMS-G
EHPSA---V--------SISVTGNSTTVCG------------------------------
-----------------GG--------------VAGFGGGISLGGS---RG--TGKSGSS
TN----------------------------------------VGYSS----------V--
KGG--SG--GTSILRKT--TTVKTSSRRY-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MIARQQSVR-----G-ASRGFSSGSAI-ASG----VKRV-AFSSAS---MSGGA----
-----------------------------------------GRCS-SRGFGSRSLYNLGG
H-KSISMSVAGSCQ-GG-GYGGAGG-----------FGAGGFG-----------------
-------------AGGFG----------------SGFGAGGFG-----------------
---GGFGG----SFN--GRGGPGFP-VC--PAGGI------QEVTINQSLLTPL----QV
EIDPEIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQQQTTTT----SPRSL--DPFFE-TYINALRKHLDSLTN
DKGRLQSELKL-MQDSVEDFKTK-YEDEINKRTA---AENDFVVLK--K---DVDAAYMI
KVDLEARVDSLKDEINFLRVLYEA-----ELSQMQTHVSDT----SVVLSMDNNRNLDLD
GIIA-EVRAQYEEIAQ-RSKAEVESWYQNK--VQQLQISVDQHGDNLKSTKNEISELN--
RMIQRLRAE-I--ENVKK------------------------------------------
-----Q-CQ--TLQTSVAEAEQ-RGEAAL-QDAYSKR----AELENALNKAKEDLARLLR
DYQALMNVKLALDVEIATYRKLLEGGL--------------------------G------
--FGL---R--------TSSVVGGSASIGG------------------------------
---------------SAGIG---GG---------------------------AGIGL---
---GLGS------------------------GFGSGSG--SGSGFGF--G-GG-------
----VYGSSGTKITSTTTVT--KRSQR---------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------VR------------------
----FLEQQNK-MLETKWSLLQQ-QKT-----ARSNM--DNMFE-SYINNLRRQLEALGQ
EKLKLEAELGN-MQGLVEDFKNK-YEDEINKRTE---MENEFVLIK--K---DVDEAYMN
KVELESRLEGLTDEINFLRQLYEE-----EIRELQSQISDT----SVVLSMDNSRSLDMD
GIIA-EVRAQYEDIAN-RSRAEAESMYQVK--YEELQLQAGKHGDDLRRTKTEISEMN--
RNISRIQAE-I--EALKG------------------------------------------
-----Q-RA--TLEAAIADAEQ-RGELAI-KDANAKL----AELEAALQRAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEES---------------------------RLE-S
---GM---Q--------NMSIHTKTTTG--------------------------------
---------------YAG---------------------GLSS-----------------
---GFG------------------------------SLASPGLNYGLS-F-------Q--
--------------------------------SG---------FGPGG---------GSS
SFTRS----------------------KAVVVKKI------ETRDGKLVSESSDVLAK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
-M--SSKSTMR--SH-SSSHRGFSAGSARVPG-----VSRS-GFSSVS-VSRSRGSGGLG
A-------------------------------VC-----------GGAGFGSRSLYNLGG
S-KRISIGGG----SC--AIGGG-------------YGS--RV----GGGYGFGGGA-G-
--------------SGFGFG--GG--A------GS-----------------GF----GL
G--GG-AGFGG-GYGGSGFP------VC--PPGGI------QEVTINQNLLTPL----NL
QIDPAIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGAK----PARQSL--EPLFE-QYINNLRRQLDSILG
EKGRLDSELRG-MQDTVEDFKNK-YEDEINKRTA---AENEFVTLK--K---DVDAAYMN
KVELQAKVDSLTDEINFLRAFYDA-----ELSQMQTHISDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEEIAQ-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEIAEMN--
RMIQRLRSE-I--DHVKK------------------------------------------
-----Q-CA--SLQAAIADAEQ-RGEMAL-KDARSKL----EGLGDALQKAKQDMARLLK
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLN-G
EG--VG-QV-------N-ISVVQSTV----------------------------------
------------SGGYGGASG-------------------------A-------------
---------------------------------------GSGIGLGGGSG----YS----
-----------------------YSSG--------------HSLG--------------G
GFSSS---SGRGLG--GGLS--SVGGG-NSSIKYT----TTTT-----------------
------------------------------------------------------------
------------SSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MIARQQGIR-----G-TSRGFSSGSAI-IGG----GKRV-AFSSAS---MSGGT----
-----------------------------------------GRCS-SGGFGSRSLYNLRG
N-KNI-CSVAGSPQ-GS-GFGCAGG-----------YG----------------------
-------------TGSFG----------------AGFGIGGFG-----------------
---GGFGG----SFG--RRGGAGFL-VC--PAGGI------QEVTINQSLLTPL----HV
EIDPEIQK--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWKLLQQQTTTT----SSRNL--DPFFE-TYISALRKQLDALAN
EKGRLQSELKM-MQDSVEDFKTK-YEDEINKRTA---AENDFVVLK--K---DVDAAYMN
KVELEAKVDSLNDEINFLRILYEA-----ELSQMQNHVSDT----SVVLSMDNNRDLDLD
SIIA-EVRAQYEEIAQ-RSKAEVEAWYQTK--VQQLQTSVDQHGDNLKSTKNEISELN--
RMIQRLRVE-I--ENVKK------------------------------------------
-----Q-CQ--TLQTSVADAEQ-RGELAL-KDAYSKR----TELEVALQKAKEELARMLR
EYQQLLSVKLALDIEIATYRKLLEGEE--------------------------C-RMS-G
ECQSAVSIS--------V---VGGSVSSG-------------------------------
-------------------------------------------------------GR---
---GFGL------------------------GAGFGSG--SGSGFGF--S-GG-------
----VSGSSGGKTISTTTTLT-RRSQR---------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
----------------------------------------------------------MR
-SSVSRQTYAT--------KGGFSSNSASGG---GGSRTHT-SFSSVT-MSRSGGSGGG-
--------------------------V--------------RCGPRMGGFGSRSLYNLGG
S-KSISVSVA---SSG-RGL----------------------------------------
--------------GGFGLS------------------SVAYG-----------------
-------GLA-------AGRQTFGP-VC--PPGGI------QEVTVNQSLLTPL----NV
EIDPEIQR--VRT QEREQIKTLNNKFACF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQGQNVG--VTK-NL--EPVFE-AFLNSMRRDLDSKLG
ERGRLDTELRN-VQDGLEDFKNK-YEDEINKRTA---LENEFVVLK--K---DVDAAYMA
KMDLQGKADSLIQEIDFLQSLYEM-----ERSQIQTHVSDT----NVVLSMDNNRNLDLD
SIIA-EVKAQYELIAQ-RSRAEAEAWYQTK--YEELQVTAGKHGDNLRDTKNEIAELT--
RTIQRLQCE-V--DAAKK------------------------------------------
-----Q-CQ--QLQAAIAEAEE-RGELAL-KDAKKKL----GDLDTALHQAKEDLARLLR
DYQALMNVKLALDVEIATYRKLLESEE--------------------------S-RMS-G
ECPSA---V--------SISVTGNSTTMCG------------------------------
-----------------GS--------------ATGFGGGISIGGG---VG--ASKGGFS
TN----------------------------------------VGYST----------A--
KGGHVSG--GTSILRKT--TTVKTSHRRY-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------MSQLSYSSRSAAGPAG----FSQV-RVSSV----SSS------
-----------------------------------RGIGGGSSFRKPGGFGSSSLYNLGS
S-KRISLGGGV-GG-G-GSSFSVRS-----------------------------------
---------------SYGYG-------GG-------------------------------
------------LGSAYGGGYGGPL-----PSPGI------QEVTINTNLLSPL----NL
EIDPTIQK--VRKEEKEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKYSLLQEQKTT-----KS-NL--APIFE-TYISNLRRQLDSLMN
DKGRLEGELRN-MQDLVEDFKSK-YEDEINKRTT---AENDFVVLK--K---DVDASYMN
KVELESKVDGLTDEVNFLREFYEA-----ELRELHNQISDT----SVVLQMDNNRNLDLD
SIIA-EVKAQYEEIAN-KSRAEAEAFYQTK--YEALQVTAGKHGDDLRNTKTEISDLN--
RTIQRMQAE-I--ENIKN------------------------------------------
-----Q-RG--KLEAAITEAEE-RGELAV-KDARAKL----QELENALNKAKQEMARQLR
EYQELMNVKMSLDIEIATYRKLLEGEE--------------------------S-RLA-G
DGAGS---V--------SMTVLNTTGSSAYGSGS--------------------------
-G----YG-SGS--GYG-------------------SGSGYGYGIGIGSGM-GSRSVGFS
SGGGGGQGS--I------------------------------------------------
--------KTTYSVSSS-TSQRSVRN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------M--
----NRQVSKT--S--GGGSRGFSGRSAVVSG------SSR-M-SS---VARSGGA-S--
-----GG-------------------------ACGIR----GG---AGGFGSHSLYNLG-
N-KSISISVAGSRA-C----FGGRS------SCVSGFGGGYGGGFGSXXG----------
---------------------------------A-----GGFGG----------------
--PG--FGPG--GFGG---PGGFGP-GG--FPGGI------QEVTVNQSLLQPL----NV
EIDPQIGQ--VKAQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWELLQQQGTNSI--TGTNNL--EPLFE-NHINLLRSYLDGIIG
ERGRLDSELRN-MQDLVEDFKKK-YEDEINKRTA---AENEFVTLK--K---DVDTAYMN
KVELQAKVDALMDEINFLRTLYDA-----ELSQMQSHVSDT----SVVLSMDNNRDLDLD
SIIA-EVRAQYEEIAQ-RSKAEAEALYQTK--LGELQTTAGRHGDDLRNTKSEISEIN--
RMIQRLRAE-I--ENVKK------------------------------------------
-----Q-A--------SLEAXX-RGEMTL-KDGNKQE----L----EALQQKDDLARLLR
D-QELMNVKLALDVEIATYRKLLEGEE--------------------------CSRMS-G
ECQSA---V--------SISVVSNSN----------------------------------
-------TTSASAGGYGGGFGG-------------GFGVGG-------------------
---------------------------------------GAGSGFGRGGG--SGFGSG--
SGFGGGSGFG--------------------G---------GSGFGGGSSG--F-SGGSSF
GSGSG--GR-CGVSGGGFSS----GSNRGSSIKFS----QSS------------------
------------------------------------------------------------
----------QRH-AR--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---YSQQSCR---ASSGSRRQGFSGHSAVVSGQSRVTSSKS-S----L-ASRSGGGG---
-------------------------------------AGSAACALMGGGFGSQSLYNLGG
N-KKISISLAGGSI-RAG-G---FRSTSGGYSGGCGFGGGGRGM-----GGGF--G----
-----------GRAGGFGGGV-------------------------G-----------GF
G----------------------GP-GG--FPGGI------QEVTVNQSLLQPL----NV
EIDPQIGQ--VKAQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWSLLQEQGSGTN--TNNRNL--EPFFE-NYISSLRAFLDGLHV
EKDKLHEELRS-MEGMVEDFKKR-YEEEINKRTA---AENDFVVLK--K---DIDAAYMT
KVELEAKVDSVTDEINFLKALYDA-----ELSQMQLDTGDT----SVVLSMDNNRCLDLD
SIIA-EVRAQYEAIAQ-RSKAEAEALYQSKIQLGELQTTAGMHGDDLKSIKTEIMEFN--
RMIQRLRAE-I--ESVKK------------------------------------------
-----QNAN--LQT-AIADAEQ-HGEVAL-KDANAKL----QDLKAALQQAKEDLARLLK
EYQELMNVKLALDIEIATYRTLLEGEE--------------------------C-RMS-G
ECQS-S--V--------SIEMVHNTTS--S------------------------------
------------SSGGSGALGGG----------------------------AGGR-----
-G-GLGSGGLGSGSLGSG-------------------------RLGSGGR-D----SRAS
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTQKSYK--LS--TSGPQAFSSHSYSSGPS-----ACI-SSLSF-------------
-------------------------------------------------------SQVGS
-----------------------S-----------SFRGG------------LGG-----
---------------GYG------------------------------------------
-----------------GASG----------MGGI------TAVMVNQNLLSPL----VL
EVDPNIQA--VCT QEKEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-MPETKWSLLQQ-QKM-----TRSNM--DNKFE-SYINNLRRQLEILGQ
EKLKLEAELGN-MQGLVEDFKNK-YEDEINKRTE---MENEFVLTK--K---DVDEAYMN
KVELESRLEGLTEEISFLRQLYEE-----EIQELQSQISDT----SVVLSMDNSHSLDMD
SVIA-EVKAQYEETAS-RSQA----EA------ESMYQIENEELQEP------GWEIN--
RNISRLQAE-I--EGPKG------------------------------------------
-----Q-RA--SLEAAIADAQQ-RGELTI-KYANAKL----SELEAALQRAKQDMLRQLR
EYQELMNVKLVLDVEIATYRKLLEGEES---------------------------RLE-S
---GM---Q--------NMSIHTKTTSG--------------------------------
---------------YAG---------------------GLSS-----------------
---AYG------------------------------GLTSPSLSYGLG------------
---------------------------------S--------SFGSGA---------GSS
SFSHT-------------------SSSRAVVVKKI------ETRDRKLVSESSDSCPSE-
--QLRQP--LQ----ACPFCAAPEPG-REATMQGSTG----NRRPT--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------S-------------FGT-------------------R-
------------------------------------------------------------
----------S-GYGFGG--------SL--SPGGI------QEVTVNQSLLTPL----NL
EIDPSIQR--VRKEEKEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQEQ--K----TTRSNI--APMFE-TYISNLRRQLDGLLA
DKGRLEGELKN-MQDLVEDFKTK-YEDEINKRTA---AENEFVVLK--K---DVDAAYMN
KVELEAKVDALTDEINFLRAFHEA-----ELNELQAQISDT----SVVLSMDNSRNLDLD
SIIA-EVKAQYEEIAN-RSRAEAESWYQSK--YEALQVTAGKHGDDLRNTKNEITEIN--
RVIQRIQGE-I--ENAKA------------------------------------------
-----Q------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------M--
----SRQASKT--S--GGGSQGFSGHSAVVSG------SSR-M-SC---VTRSGVA-G--
-----GG-------------------------AYGFR----SG---AGGFGSRSLYNLGG
N-KSISISVAAGGS-RAGGFGGGRS------S--CGFAGGYGGGFGGGYG----GGFGGV
--R--GMGGGFGGAGGFG--------GAGGFGGA-----SGFGGPGGFGGPGVFGGLGNF
GSPGGF---------G---P------GG--FPGGI------QEVTINQSLLQPL----NV
EIDPQIGQ--VKAQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQQQSTSSI--SGTNNL--EPLFE-NHINYLRSYLDNILG
ERGRLDSEMRN-MQDLVEDFKKK-YEDEINKRTA---AENEFVTLK--K---DVDSAYMN
KVELQAKVDALIDEINFLRTLYDA-----ELSQMQSHISDT----SVVLSMDNNRSLDLD
SIIA-EVRAQYEDIAQ-RSKAEAEALYQTK--LGELQTTAGRHGDDLRNTKNEIIELN--
RMIQRLRAE-I--ESIKK------------------------------------------
-----Q-NA--NLQTAIAEAEQ-RGEMAL-KDANAKL----QELQAALQQAKDDLARLLR
DYQELMNVKLALDVEIATYRKLLEGEE--------------------------Y-RMS-G
ECPSA---V--------SISVVSSST----------------------------------
--------TSASAGGYAGGYGG-------------GVGGGLGGGL---------------
--------------------GA----GGG-----------SSSGFGRGGG--GGLGG---
---GIGGGF--------------GGGS--------------------SSG--F-SGGSGF
GSSSG--AR-YGVSGGGFSS----ASNRGGSIKFS----QSS------------------
------------------------------------------------------------
----------QSS-QRYSR-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

MTSVGVF---------SDMLNGCGKDGLVPRAKPRDVSDFSLYAPATKPCCS--------
------------------------RTYKRPRLRAPALTGLGPV----T---SLIAPSSLS
AAMIARQQCVR-----G-GPRGFSCGSAIVGGG----KRG--AFSSVS---MSGGA----
-----------------------------------------GRCS-PGGFGSRSLYNLRG
N-KSISMSVAGSRQ-GA-CFGGAGG-----------FGTGGFG-----------------
------A-------GGFGA----------------GFGTGGFG-----------------
---GGFGG----SFS--GKGGPGFP-VC--PAGGI------QEVTINQSLLTPL----HV
EIDPEIQK--VRT EEREQIKLLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQQQTTTT----SSKNL--EPLFE-TYLSVLRKQLDTLGN
DKGRLQSELKT-MQDSVEDFKTK-YEEEINKRTA---AENDFVVLK--K---DVDAAYMN
KVELEAKVDSLNDEINFLKVLYDA-----ELSQMQTHVSDT----SVVLSMDNNRNLDLD
SIIA-EVRAQYEEIAQ-RSKAEAEALYQTK--VQQLQISVDQHGDNLKNTKSEIAELN--
RMIQRLRAE-I--ENIKK------------------------------------------
-----Q-CQ--TLQASVADAEQ-RGENAL-KDAHSKR----VELEAALQQAKEELARMLR
EYQELMSVKLALDIEIATYRKLLEGEE--------------------------Y-RMS-G
ECQSA---V--------SISVVSGSTSTGG------------------------------
---------------ISR-G---LGS-----------------------------GS---
---GFGL------------------------SSGFGSG--SGSGFGF--G-GS-------
----VSGSSSSKIISTTTLNKRR-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTQKSYK--LS--TSGPQAFSSHSYSSGPS-----ACI-SSLSF-------------
-------------------------------------------------------SQVGS
-----------------------S-----------SFRGG------------LGG-----
---------------GYG------------------------------------------
-----------------GASG----------MGGI------TAVMVNQNLLSPL----VL
EVDPNIQA--VCT QEKEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-MPETKWSLLQQ-QKM-----TRSNM--DNKFE-SYINNLRRQLEILGQ
EKLKLEAELGN-MQGLVEDFKNK-YEDEINKRTE---MENEFVLTK--K---DVDEAYMN
KVELESRLEGLTEEISFLRQLYEE-----EIQELQSQISDT----SVVLSMDNSHSLDMD
SVIA-EVKAQYEETAS-RSQA----EA------ESMYQIKNEELQEP------GWEIN--
RNISRLQAE-I--EGPKG------------------------------------------
-----Q-RA--SLEAAIADAQQ-RGELTI-KYANAKL----SELEAALQRAKQDMLRQLR
EYQELMNVKLVLDVEIATYRKLLEGEES---------------------------RLE-S
---GM---Q--------NMSIHTKTTSG--------------------------------
---------------YAG---------------------GLSS-----------------
---AYG------------------------------GLTSPSLSYGLG------------
---------------------------------S--------SFGSGA---------GSS
SFSRT-------------------SSSRAVVVKKI------ETRDRKLVSESSDSCPSE-
--QLRQP--LQ----ACPFCAAPEPG-REATMQGSTG----NRRPT--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTQKSYK--MST--SGPRAFSSRSFTSGPG-----ARI-SSSSF-------------
-------------------------------------------------------SRVGS
S---------------------SS-----------SFRGS------------MGTGV---
--------------GL---G----------------------------------------
---------------GF---GGA-------GVGGI------TAVTVNQSLLSPL----KL
EVDPNIQA--VRT QEKEQIKSLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQQ-QKT-----SRSNM--DNMFE-SYINNLRRQLEALGQ
EKLKLEAELGN-MQGLVEDFKNK-YEDEINKRTE---MENEFVLIK--K---DVDEAYMN
KVELESRLEGLTDEINFLRQIHEE-----EIRELQSQISDT----SVVLSMDNSRSLDMD
GIIA-EVRAQYEDIAN-RSRAEAETMYQIK--YEELQTLAGKHGDDLRRTKTEISEMN--
RNINRLQAE-I--EALKG------------------------------------------
-----Q-RA--SLEAAIADAEQ-RGEMAI-KDAQTKL----AELEAALQRAKQDMARQLR
EYQELMNVKLALDIEITTYRKLLEGEES---------------------------RLE-S
---GM---Q--------NMSIHTKTTSG--------------------------------
---------------YSG---------------------GLSS-----------------
---SYG------------------------------GLTSPGFSYGMSSF-------Q--
--------------------------------PG---------FGSAG---------GSN
TFSRT---------------------TKAVVVKKI------ETRDGKLVSESSDVVSK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

MGARIILCQPRRAWGQGEKVASCPRQSRLSPS-----SGAQVITGRAPPSCLGRGHSPWP
TGPLPLPLGRWGRSVCGAGEPAQLGKDKKPTVAQQ----LTALPSCLLILPSGPS-AAMR
-SSVSRQTYST--------KGGFSSNSASGG---SGSQART-SFSSVT-VSRSSGSGGG-
--------------------------A--------------RCGPGTGGFGSRSLYNLGG
H-KSISVSVAGGASSG-RAL----------------------------------------
--------------GGFGFG------------------SRAFM-----------------
-------GQG-------AGRQTFGP-AC--PPGGI------QEVTVNQSLLTPL----HV
EIDPEIQR--VRTQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQSQNLG--VTRNNL--EPLFE-AYLDSMWSTLDRLQS
ERGRLDSELRN-VQDLVEDFKIK-YEDEINKRTA---AENEFVVLK--K---DVDAAYMG
RMDLHGKVGTLTQEIDFLQQLYEM-----ELSQVQTHVSNT----NVVLSMDNNRNLDLD
SIIA-EVKAQYELIAQ-RSRAEAEAWYQTK--YEELQVTAGKHGDNLRDTKNEIAELT--
RTIQRLQGE-A--DAAKK------------------------------------------
-----Q-CQ--QLQTAIAEAEQ-RGELAL-KDAQKKL----GDLDVALHQAKEDLTRLLR
DYQELMNVKLALDVEIATYRKLLESEE--------------------------S-RMS-G
ECPSA---V--------SISVTGNSTTVCG------------------------------
-----------------GG--------------TASFGGGISLGGS---GG--ATKGGFS
TN----------------------------------------VGYST----------V--
KGWPVSG--GTSILRKT--TTVKTSSQRY-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQSSVS--FR-SGGSRSFSTASAITPS-----VSRT-SFTSV---SRSGG--GGG
GFGRVS--------------------------LG-------GACGV-GGYGSRSLYNLGG
S-KRISISTS----GG--SFRNR-------------FGAG--A----GGGYGFGGGA-G-
--------------SGFGFG--GGAG--------G-----------------GF----GL
G--GGA-GFGG-GFGGPGFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPSIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVRQNL--EPLFE-QYINNLRRQLDSIVG
ERGRLDSELRN-MQDLVEDFKNK-YEDEINKRTT---AENEFVMLK--K---DVDAAYMN
KVELEARVDALMDEINFMKMFFDA-----ELSQMQTHVSDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEEIAN-RSRTEAESWYQTK--YEELQQTAGRHGDDLRNTKHEISEMN--
RMIQRLRAE-I--DNVKK------------------------------------------
-----Q-CA--NLQNAIADAEQ-RGELAL-KDARHKL----AELEEALQKAKQDMARLLR
EYQELMNTKLALDVEIATYRKLLEGEE--------------------------C-RSN-K
WAMQDQ-PG-------R-RSVVTSSV----------------------------------
------------SSGYGGGS-G--------------YGG--GLGGGLGGG----------
------------L--------------------------GGGLG-GGSSG----SYYSS-
------------------------SSG-----GVGLG--SGLSVGG-------------S
GFSAS---SGRGLGVGFGS---GG-G-SNSSVKFV----STTS-S---------------
------------------------------------------------------------
-------------SRKSFKS----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTQKSYR--VST--TGPGAFSSRSFASGPS-----ARS---SSF-------------
-------------------------------------------------------SRVSS
-----------------------T-----------GFLGG------------LGAGY---
--------------AG---A----------------------------------------
---------------S-----GI-------GLGGI------TAVTINQSLLNPI----KL
DMDPNIQA--VCT QEKEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQQ-QKT-----ARSNM--DNMFE-SYINNLRRQLETLGQ
EKLKLEAELGN-MQGLVEDFKNK-YEEEINKRTE---VENESVLIK--K---DVDEAYMN
KVELESRLEGLTDEINFLRQLYEE-----EIRELQSQISDT----SVVLSMDNSRSLDMD
SIIA-EVKAQYEEIAN-RSRAEAESMYQIK--YEELQKLAGKHGDDLRRTKTEISEMN--
RNISRLQAE-I--EGLKG------------------------------------------
-----Q-RA--SLEAAIIDAEH-RGEQAL-KDARAKQ----QQLEEALQKAKQDIARQLR
DYQELMNVKLALDIEIATYRKLLEGEES---------------------------RLE-S
---GM---Q--------NMSIHTKTTSG--------------------------------
---------------YAG---------------------GLSS-----------------
---ACG------------------------------GLTSPGLSYGLG------------
--------------------------------SS---------FGSGA---------GS-
TFSCT-------------------SSTKAVVVKKI------ETRDGRLVSESSDVLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSSKTTVR--SQS-TSRRGFSASSARVPG-----LSRS-GFSSVS-VCRSRGSGGTG
A-------------------------------MY-----------GGAGFGSRSLYNLGG
S-KRISIGGG----SC--AIGGG-------------YGS--RV----GGGFGFGGGI-G-
--------------NGFGYG--GG--A------GS-----------------GF----GL
S--GG-AGFGG-GYGGAGFP------VC--PPGGI------QEVTINQSLLTPL----NL
EIDPTIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWSLLQEQGTR----TVRHSL--EPLFE-QYINNLRRQLDSIVS
ERGRLDSELRN-MQDAVEDYKNK-YEDEINKRTT---AENEFVTLK--K---DVDAAYMN
KTELQAKADGLVDEINFLRALYEA-----ELSQMQTHVSDT----SVILSMDNNRSLDLD
SIIA-EVRAQYEEIAQ-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEIAEIN--
RMIQRLRSE-I--DHVKK------------------------------------------
-----Q-CA--NLQAAIADAEQ-RGELAI-KDARSKL----EGLEDALQKAKQDMARLLK
EYQELMNVKLALDIEIATYRKLLEGEE--------------------------C-RLN-G
EG--VG-QV-------N-ISVVQSTV----------------------------------
------------SSGYGSAA------------------------SGM-------------
---------------------------------------GSGVGLGGG-S----GYTY--
------------------------SSG--------------HSLG--------------G
GFSSG---SGRGISVGGGLS--SVGG-STSSIKYT----TS-S-----------------
------------------------------------------------------------
------------SSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MAS
TPPPS---------EPQQQPQGLQCRLSQLPG-----VQRS-GFSSVS-VSRSRGQW---
-----A-----------------------------W----VGACG-GAGFGRAQPVWPVG
S-KRISMGGQL-AI-S-VGYGNRSR----R------------------------------
----------------PAMA----LGAGSGLWFRW---------------------W---
------------------SRHWLWPGWW--SRPCI------QEVTVNQSLLTPL----NL
QIDPTIQR--VRA EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWTLLQEQGTKT----VRQNL--EPLFE-QYINNLRRQLDSIVG
ERGRLDSELRG-MQDLVEDFKNK-YEDEINKRTT---AENEFVTLK--K---DVDAAYMN
KVELQAKADTLTDEINFLRALYEA-----ELSQMQTHISDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEEIAQ-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEIAEIN--
RMIQRLRSE-I--DHVKK------------------------------------------
-----Q-CA--NLQAAIADAEQ-RGEMAL-KDAKNKL----EGLEDALQKAKQDLARLLK
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RWV-T
DPV----------------------VQSTV------------------------------
------------SSGYGR----W-------------------------------------
-----P--------------------------------------AGVGSR----LSYGSC
--LGVG-----------------------------------------------------G
GFSSS--SG-RAIGGVASALLEA-ASST---IN---------------------------
------------------------------------------------------------
--------------RKSLTST---------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MNRQVCKK--SF-SGGSQGFSGRSAVVS-G-----SSR-M-SC---VARSGGA-G--
-----GG-------------------------ACSFR----SRA---GGFGSRSLYNLGG
N-KSISISVAAGGS-RAGGFVGGQS------SCG--FAGGYGGG----FGGSYGGGFGGG
--R--GIGSGFG-------------------------------RAGGFGEAGGF------
GGPGVFGGLG--SFGS---PGGFVP-GG--FSGGI------QEVTVNQSLLQPL----NV
EIDPQIGQ--VKA QEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWELLQQQTTG----SGPSSL--EPCFE-SYINFLRKQLDSLLA
ERGNLEGELKS-TQDLVEDFKKK-YEDEINKRTA---AENEFVGLK--K---DVDAAFMN
KVELQAKVDSLTDEVSFLRTLYEM-----ELSQMQSHVSDT----SVVLSMDNNRCLDLD
NIIA-EVRAQYEEIAQ-RSKAEAEALYQTK--LGELQTTAGRHGDDLKNTKSEIMELN--
RMIQRLRAE-I--ENVKK------------------------------------------
-----Q-NA--NLQTAISEAEQ-RGEMAL-KDANAKL----QDLQAALQKAKDDLARLLR
DYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RMS-G
ECQSA---V--------CISVVSNVTST--------------------------------
---------SGSSGSSRGVFGGVSGS--------GGYRGGGSSS----------------
-------------------SSSA-YGAVSG---------GSSSS-YGGVS-SG---ST--
GGRGSSGGYQ--------------------SSSS------GSRLGGAGSMS---MSHSGM
GSSSG--SV-QTSGGSGYKS----GGGGSTSIRFS----QTT------------------
------------------------------------------------------------
----------SSS-QHNSTK----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MNRQVSKK--SF-SSGSQGFSGRSAVVS-G-----SSR-M-SC---VARSGGA-S--
-----GG-------------------------ACGFR----SGA---GGFGSHSLYNLGG
N-KSISISVAGGGS-RVAPHA---------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------QLKR-LTPFLPP------LTQ--VR------------------
----FLEQQNK-VLETKWELLQQQTTGSG--SGPSSL--EPFFE-SYISFLSKQLDSLLG
ERGNLEGELKN-MQDLVEDFKKK-YEDEINRRTT---AENEFVGLK--K---DVDAAYMN
KVELQAKVDSLMDEVNFLRTLYDM-----ELSQMQSHVSDT----SVILSMDNNRCLDLD
SIIT-EVRAQYEDIAQ-RSKAEAEALYQTK--LGELQTTAGRHGDDLRSTKSEIAELN--
RMIQRLRAE-I--ESVKK------------------------------------------
-----Q-NA--NLQTAIAEAEQ-RGEMAL-KDANAKL----QELQTALQKAKDDLARLLR
DYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RMS-G
ECQSA---V--------SISVVSNVTST--------------------------------
---------SSSAGGSRGGFGGVSGS----SS--GGYRGGVS------------------
------------------GGSSS-YGGVSG---------GSSSG-YGGVS-SG---SS--
GSRGSSGGYQ--------------------SGSS------GSRLGGAGSSS---VSQSGM
GSSSG--GI-QTSG--GYKS----GSGGSTSVRFS----QTT------------------
------------------------------------------------------------
----------SSS-QYSSK-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------SNLCSRSL---LSLARPPSSSASTMST
--RVTQKSFK--VST--SGPRTFSSRSYTSGPS-----SRI-NFSTL-------------
-------------------------------------------------------SRVGS
S----------------------------------GFRGS------------MGAGL---
--------------GL---G----------------------------------------
---------------LGYGG-AG-------SVGTI------TAVTLNQSLLNPV----KL
MDTNDLQA--VRMQEKEQIKSLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWRLLQQQQKT-----SRSDM--DSLFE-SYISNLRRQLEGLGQ
EKLKLEAELGN-MQGLVEDFKNK-YEEEINKRTD---MENEFVLIK--K---DVDEAYMN
KVELESRLEGLTEEINFLRHLYEA-----ELAELQAQISDT----SVVLSMDNSRSLDLD
GIIA-EVKAQYEEIAN-RSRAEAESMYQIE--YEKLQTLAGKHGDDLRRTKTEITEMN--
RSISRLQAE-I--EGLKG------------------------------------------
-----Q-RA--SLEAAITEAEQ-RGELAV-KDANAKL----AQLEAALQQAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEEG---------------------------RLE-A
---GM---Q--------NMSIHTRTSSS--------------------------------
---------------GY-------------------HSGGLSP-----------------
---V------------------------------------VGLNLGSS--------PF--
---------------------------------Q--------GLASPG---------GSG
L---V-------------------IRNKALVVKKI------ETRDGKLVSESSDVLSN--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--M-SRQSTIT--FHT-GSRRGFSTTSATTPA-----AGRS-RFSSVS-VARSVG--STG
GPGRIS--------------------------SV------------GAGFGSRSLYNLG-
T-KRVSVGGCGGSG-----FRSG-------------FGG--RA----SSVFGV-----N-
--------------SGFSYG--GGIGGGF-------------------------------
--------------GGSGLP------SC--PSGGI------QEVTVNQSLLTPL----NL
QIDPTIQR--VRK EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQEQGSR----TVRQNL--EPLFD-AYINDLRRQLDGVTT
ERGRLDAELRN-MQEVVEDFKVR-YEDEINKRTA---AENEFVALK--K---DVDGAYMN
KVELEAKVGSLTDQLNFLRMIFEA-----ELSQMQNQVSDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEDIAN-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEISEMN--
RMIQRLRAE-I--DSVKK------------------------------------------
-----Q-CA--SLQTAIADAEQ-RGELAL-KDARAKL----VDLEEALQKAKQDMARLLR
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VS-PVNIS--------VVTNTV----------------------------------
------------SSGYGGGS--GIG-----------------------------------
---------------------------------------SGNLGLNGGSS----YSFTT-
-----------------------SG-------GHSLS--S--GLGG-------------S
GFTTS---SSRGLGG------------SGSSVKFV----STTS-----------------
------------------------------------------------------------
--------------RKTYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSSKTTI---RS-QTSHRGINVSSAILPR-----LNHP-GFSSVS-VCCSGGNNGSG
V-------------------------------LF-----------GGAGFGSRSLYGVGS
S-KRISIGRG----SC--GIGGG-------------YGS--RV----GGGFSFGG-----
--------------------------A------SS-----------------GF----GF
G--GG-AGFGG-DYGGTGFP------VC--PPGGI------QEVTINQNLLTPL----K-
-FPPPIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-ILDTKWALLQEQGTK----IMRPNV--EDLFE-HYISTLRREENYILG
QRSHLDSELKS-MQDTVEDYKNK-YEDEIRKRTA---AENEFVTLK--K---DVDADYMN
KVELQGRADSLADEINFLRTVFDA-----ELSQMQTHISDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEEIAQ-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEIAEIN--
RMIQRLRSE-I--DHVKK------------------------------------------
-----Q-CA--NLQAAIAEAEQ-RGEMAL-KDARGKL----EGLEDALQKAKQDMARLLK
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLY-G
EG--VG-QV-------N-ISVVQSTV----------------------------------
------------SSSYGSAGG-------------------------A-------------
---------------------------------------SSSLGLGGGSS----YS----
-----------------------YSSS--------------HGLG--------------G
GFSSG---SGRGIS--GGLS--SSGGS-SSTIKYT----TTSS-----------------
------------------------------------------------------------
-------------RRKSYRH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQACKQ--SF-SFGSQGFSGHSAVVSG------SSR-R-SC---VARTRAA-G--
-----GG-------------------------AYGFR----SG---AGSFGSQSLYSLGG
S-RSISISVAGG------GLGGGHG------SCGSSFGGGYGGGFGGSRG----------
------IGA------------------------------------------SGFGGASGF
GGAS--------GFGR---PGGFGP-GG--CPGGI------QEVTINQSLLQPL----NV
EIDPEIGQ--VKA QEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQQQTTGSG--SGPQSL--EPFFE-SYISCLRKRLDSLLG
EKGSLEGELRN-MQDLVEDFKKK-YEEEVNRRTA---AENDFVGVK--K---DVDVAYMN
KVELQARVDSLTDEINFLRTLYDM-----ELSQMQSHVSDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEEIAQ-RSKAEAEALYQTK--LGELQTTAGRHGDDLKSTKSEIMDLN--
RMIQRLRAE-I--ENAKK------------------------------------------
-----Q-NA--NLQASIAEAEQ-RGEGAL-KDADAKL----QELQAALQKAKDDMARLLR
DYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-SSS-G
GFRGA---G--------GNSSSGSRGS---------------------------------
--------SSSS----SGGFRGPGGS----SS--S----GS-------------------
----------------RPGGSS------------------------SSSS--G-------
----------------------------DFRGAG------GSNYGGDSSV--SNSRQRGM
-------GT-QASVGDSYKS----GRGGGSSVHFS----QTT------------------
------------------------------------------------------------
----------SSS-QQRSK-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
-----------------------------------------------M-ANKDNIASFST
PGNMSSKTTVR--SQS-SSRRGFSASSARGPG-----LSRS-GFSSVS-VCRSRGSGGIG
A-------------------------------AC-----------GGAGFGSRSLYGLGG
S-KRISIGGG----SC--ATGGG-------------YGS--RI----GGGFGFGGGA-G-
--------------SGFGYG--GG--A------GS-----------------GF----GL
G--GG-AGFGG-GYGGAGFP------VC--PPGGI------QEVTVNQSLLTPL----NL
EIDPTIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVRQNL--EPLFE-QYINNLRRQLDSIQG
ERGRLDSELRS-MQDTVEDYKNK-YEDEINKRTA---AENEFVTLK--K---DVDAAYMN
KTELQAKVDSLVDEINFLRAFYDA-----ELSQMQTHISDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEEIAQ-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEITEIN--
RMIQRLRSE-I--DHVKK------------------------------------------
-----Q-CA--NLQAAIADAEQ-RGELAL-KDARNKL----EGLEDALQKAKQDMARLLK
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLN-G
EG--VG-QV-------N-ISVVQSTV----------------------------------
------------SSGYGSA-------------------------SGM-------------
---------------------------------------GSGVGLGGG-S----SYSY--
------------------------SSG--------------HSLG--------------G
GFSSG---SGRGISTGGGLS--SVGG-STSSIKYT----TS-S-----------------
------------------------------------------------------------
------------SSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSR
PFS-SRSGYRS--G------RNFSSGSAGVVS-----LQRR-TTSSS--VRSSGGGG---
G--RFS------------------------GGRCGG-G-------AGGGFGSRSLVNLGG
S-KSISISVARGGG-R-SGFGGG---------Y-C---AGGFGG------GGFGG-----
--------------GGF----------------GGGFGSGGLGGG--FGS----KGGFG-
A---------G-GLIGGGFGGGLGP-VC--PPGGI------QEVTINQSLLQPL----NV
EIDPEIQK--IKSQEREQIKSLNNQFASF------IDK--VR------------------
----FLEQQ-Q-VLQTKWELLQQMDTST----RTQNL--EPYFE-SYINNLRKRLDQLKS
DQSRMNSELKN-MQDLVEDYRNK-YEEEINKRTN---AENEFVTIK--K---DVDAAYMT
KVDIQAKVDNLRQEIDFLTALYQA-----ELSQMQTHISET----NVVLSMDNNRNLDLD
SIIA-EVKAQYEEIAQ-RSKAEAEALYQTK--YEELQVTAGKHGDNLKTSKMEISELN--
RIIQRLRSE-I--DSVKK------------------------------------------
-----Q-IS--GLQQSISDAEQ-RGENAL-KDAQGKL----NELEDALQKAKEDLARLLR
DYQELMNTKLALDMEIATYRTLLEGEE--------------------------C-RMS-G
ECAP-N--V--------SVSVSTSHTSISG------------------------------
------------GGSRGFGSGGGSYG----TGGGSSYGTG-----------GGSYGS---
---GS--------------------------------------GSYGS--------GG--
-------GGGG-----------GGSSGGH-RSGS------GGGGGSSGGR-GSGGGGSSR
GSFGG--S----SGGWGSSSGGTKTSGGSSSVKFI----STS------------------
------------------------------------------------------------
----------YSR-GSR-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQSSVS--FR-SGGSRGFSTASAITPS-----VSRT-SFTSV---SRSGGG-GGG
GFGRVS--------------------------LG-------GACGV-GGYGSRSLYNLGG
S-KRISISTS----GG--SFRNR-------------FAAG--A----GGGYGFGGGA-G-
--------------SGFGFG--GGAG--------G-----------------GF----GL
G--GGA-GFGG-GFGGPGFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPSIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVRQNL--EPLFE-QYINNLRRQLDSIVG
ERGRLDSELRN-MQDLVEDFKNK-YEDEINKRTT---AENEFVMLK--K---DVDAAYMN
KVELEAKVDALMDEINFMKMFFDA-----ELSQMQTHVSDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEEIAN-RSRTEAESWYQTK--YEELQQTAGRHGDDLRNTKHEISEMN--
RMIQRLRAE-I--DNVKK------------------------------------------
-----Q-CA--NLQNAIADAEQ-RGELAL-KDARNKL----AELEEALQKAKQDMARLLR
EYQELMNTKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VG-PV-------N-ISVVTSSV----------------------------------
------------SSGYGGGS-G--------------YSS--GLGGGLGGG----L-----
---------GGGL--------------------------GGGLG-GGGSG----SYYSS-
------------------------SSG-----GVGLG--SGLSVGG-------------S
GFSAG---SGRGLGVGFGS---GG-G-SSSSVKFV----STTS-S---------------
------------------------------------------------------------
-------------SRKSFKS----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQ------INLKSSCRGFSSGSARVPG-----LSRS-GFSSVS-VCRSRGSGGIG
A-------------------------------VG-----------AGSGLGSRSLYGLGS
S-LRISMAGG----SC--GIRGG-------------YS---RV----GGSCGFG------
----------------------GG--A------GS-----------------GF----GF
G--GG-AGFGG-GYGGSGFP------VC--PPGGI------QEVSINQSLLTPL----NL
EIDPTIPR--VRT EEHEQIKTLNNKFASF------IDK--V-------------------
----FLEQQNK-VLQTKWTLLQEQDTK----TVRPGI--DLLFE-EYIKSLRRHLDSITT
EGSHIQSEMKN-MQGVVEDFKNK-YEDEIHRHTA---AENEFVTLK--K---DVDAASMK
EVELKTNATGLRNEVIFLTSIFEE-----ELSQMQTNISDT----SVILSMDNNRNLDLS
SIIV-EVKARNEEIAQ-RSWAEAESWYQTK--YEELQVTASRHGDDLRNTKQEIAEIN--
HMIQRLRSE-I--DHVKK------------------------------------------
-----Q-CA--SLQDTITDAEQ-RGELAL-KDARSKL----EGLEDALQKAKQDMARLLK
EYQDLTSVKLALDVEIATYRKLLEGEE--------------------------C-RLI-G
EG--LG-PTNV-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
--------------------MFL-----------------------------MRLEAPAG
TATMSRQSSVS--FR-SGGSRSFSAASAITPS-----VSRT-SFSSV---SRSGG----G
GGGRVS--------------------------LG-------GV-CGAGGYGSRSLYNLGG
T-KRISMSAS----GF--GLRNR-------------FGPGAGS----G--FGFGSGA-G-
--------------SGYAFG--GGAI-G------------------------GF----GL
G--GGTGFG-G-GYGGAGFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPTIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTR----TVKQSL--DPLFE-QYINNLRRQLDSILG
ERGRLDSELRN-MQDLVEDFKNK-YEDEINKRTT---AENEFVMLK--K---DVDAAYMN
KVELEAKVDALMDEINFMKMFFDA-----ELSQMQTHVSDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEDIAN-RSRTEAESWYQTK--YEELQQTAGRHGDDLRNTKHEISEMN--
RMIQRLRAE-I--DNVKK------------------------------------------
-----Q-CA--NLQAAIADAEQ-RGELAL-KDARNKL----AELEDALQKAKQDMARLLR
EYQELMNTKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VG-PV-------N-ISVVTNSM----------------------------------
------------STGYGSG---------------SGFGG--SLPGGLGSG----L-----
-----G----------------------------------------GGGS----SSYYS-
-----------------------SSSG-----GVGLS--GGLNVGG-------------P
GFSAS---SGKGIGVGFGS----GGG-SGSSVKFV----STTS-S---------------
------------------------------------------------------------
-------------SRRTFKS----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
H-------------F---SSQLFSSRSAGFSGR----GSQV-RLSPA----RPGG-----
----------------------------------------------VG-S--RSLYGLG-
------------AS-RPRVAV--RS-----------------------------------
---------------ASG------------------------------------------
----------------S-------P-----VGAGI------REVTINQSLLAPL----RL
DTDPSLQR--VRQ EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-LLETKWALLQEQKSA-----KSSRL--PDIFE-AQIAGLRGQLEALQV
DGGRLEVELRS-LQDVVEDFKNK-YEDEINRRTA---AENEFVVLK--K---DVDAAYMS
KVELEAKVVALNDEINFLRTLHEM-----ELTELQSQISDT----SVVLSMDNSRSLDLD
GIIA-EVKAQYEEMAK-CSRAEAEAWYQAK--FETLQAQAGKHGDDLRNTRNEIAEMN--
RAIQRLQAE-I--DAIKN------------------------------------------
-----Q-RA--KLEAAIAEAEE-RGELAL-KDARAKQ----EELEAALQRAKQDMARQLR
EYQELMSVKLALDIEIATYRKLLEGEE--------------------------S-RLA-G
DGVGA---V--------NIS----------------------------------------
---VVNST-GGSG---SGSG----------------GGIGLSFGG-----TMGSNALSFS
SS-----AGPGP------------------------------------------------
--------LKAYSIRTTSTSRRSARN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------RSLYSLGR
N-KSLSISGAGSRQ-GA-GFGGAGG-----------FGAGGFG-----------------
------SGAGFG----GG----------------AGFGAGGFG-----------------
---GAFGG----SFN--GRGGPGFP-VC--PAGGI------QEVTINQNLLTPL----HV
EIDPEIQK--VRTEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-ILETKWKLLQQQTTTT----SSKNL--EPLFE-SYIIILRKQVEGLNN
DKGRLQSELKV-MQDSVEDFKTK-YEDEINKRTA---AENDFVVLK--K---DVDAAYMT
KVELEAKVDALTDEINFLRTLYEA-----ELTQMQTQVSDT----SVVLSMDNNRCLDLD
SIIA-EVKAQYEEIAQ-KSKAEAEAWYHIK--VQQLQGSVDQYGDSLKNTKSEISELN--
RMIQRLRAE-I--ENVKK------------------------------------------
-----Q-CQ--TLQASVADAEE-RGELAL-KDARSKQ----TELEAALQQAKEELARMLR
DYQELMSTKLALDVEIATYRKLLEGEE--------------------------C-RMS-G
ECQSA---V--------SISMVGGGTSVGG------------------------------
---------------IG-GG---LGS----C---SGFG--LGG-----------------
---------------------------------GFGSG--SGSGFGF--G-GG-------
----VCGSSGSVWGGGRGDLKGQGSVKGN----K------EVNTGALEA----------F
ALAEE--SKGDSLKESTWIPSNS-SVESTRPMLFK----SLTEKDTK--SINSGTCERQH
SFWMFRGTFRPRQGWCHGDCGWPWLAWATWQCLYERVLVMVSHGEDQVLPWVRLIPQRGK
LIIFKEVTVNQSL-LQPLNVEIDPQI--GQVKAQEREQIKTLNNKFASFIDKVRFLEQQN
KVLETKWNLLQQQGTNSVTGTNNLEPLFESYISSLRNHLSYLQGERGRLDSELRNMQDLV
EDFKKKYEDEINKRTAAENEFVTLKKDVDAAYMNKVELQAKTDSLTDEINFLRTLYDAEL
SQMHTQVSDTSVVLSMDNSRSLDLDSIIAEVKAQYEEIANRSRAEAEAWYQTQLGELQTT
AGRHGDDLKSTKSEIMELNRMIQRLRAEIENVKKQIANLQTAVAEAEQRGEMALKDAKAK
LDGLETALTKAKDDLARLLRDYQELMNVKLALDVEIATYRKLLEGEECRMSGECQSAVNI
SVVSSSSTTSASAGGYGGGYGGGFGMGGGAG

------------------------------------------------------------
------------------------------------------------------------
--MIARQQYVR-----G-GSRGFSSGSAI-VGG----GKRV-AFSSAS---MSGGA----
-----------------------------------------GRCS-SGGFGSKSLYNLGG
N-RSISCSVAGSRQ-GI-GFGGAGG-----------FGAGSFG-----------------
-------------VGG--------------------FGAGSFG-----------------
---GGFGG----SFN--GRGGPGFP-VC--PAGGI------QEVTINQSLLTPL----HV
EIDPEIQK--VRTA EREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWSLLQQQTTTS----SPRNL--DPFFE-TYISALRKQLDTLGN
EKGRLQSELKI-MQDSVEDFKTK-YEDEINKRTS---AENDFVVLK--K---DVDAAYMT
KVELEAKMDGLNDEISFLRVLYEA-----ELSQMQTHVSDT----SVVLSMDNNRNLDLE
SIIA-EVQAQYEEIAK-RSKAEAEALYQTK--VQQLQTSVDLHGDNLKSTKNEISELN--
RMIQRLRTE-I--ENVKK------------------------------------------
-----Q-CQ--TIQASVADAEQ-RGELAL-KDAYSKR----TELEAALQKAKEEMARMLR
EYQALMSVKLALDVEIATYRKLLEGGG--------------------------R-EG---
--------N--------MGSVVGGSVSAGS------------------------------
------------------IG---GG---------------------------LGSYS---
---GFGL------------------------GSGFGSG--SGSGYGF--G-SH-------
--------SSSKIISSSTLT--KRSQR---------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
----------------------------------------------------------MR
-SSVSRQTYST--------KGAFSSSSASGG---GGSQART-SFSSVT-VSRNSGRGGG-
--------------------------P--------------RCGPSMGGFGSQSLYNLGG
S-KSISVSVAGGASAG-RVL----------------------------------------
--------------GGFGLG------------------GGAYM-----------------
-------GLG-------ACRPMLGP-VC--PPGGI------QQVTVNQSLLTPL----HV
EIDPEIQR--VRTEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQGQKSG--VTRNNL--EPLFE-HFINNLRGKLDNLQS
ERGRLDSELRN-VQDLAEDFKTK-YEDEINKRTA---AENEFVVLK--K---DVDAAYVG
RMDLHGMVDHLMGEIDFLRHLYEE-----ELSQVQTHVSDT----SVILSMDNNRNLDLD
SIIA-EVKAQYEQIAQ-RSRAEAESWYQTK--YEELQVTAGKHGDNLRDTKNEIAELT--
RTVQRLQGE-A--DAVKK------------------------------------------
-----Q-CQ--QLQTAIADAEQ-HGELAL-KDAQKKL----GDLDAALNQAKEDLARLLR
DYQALMNVKLALDVEIATYRKLLESEE--------------------------S-RMS-G
ECPSA---V--------SISVTGNSTTVCG------------------------------
-----------------GG--------------AAGFGGGISLGGG---GG--ASKGRFS
TN----------------------------------------AGYST----------V--
KGGPVSG--GTSILRKT--TTVKTSSRRY-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
H-------------F---SSPVFTSRSAAFSGR----GAQA-RLSSA----RPGG-----
----------------------------------------------LG-S--SSLYGLG-
------------AS-RPRVAV--RS-----------------------------------
---------------AYG------------------------------------------
----------------G-------P-----VGAGI------REVTINQSLLAPL----RL
EADPSLQR--VRQEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-LLETKWTLLQEQKSA-----KSSRL--PDIFE-AQIAGLRGQLEALQV
DGGRLEAELRS-MQDVVEDFKNK-YEDEINRRAA---AENEFVVLK--K---DVDAAYMS
KVELEAKVDALNDEINFLRTLNEM-----ELTELQSQISDT----SVVLSMDNSRSLDLD
SIIA-EVKAQYEEMAK-CSRAEAEAWYQTK--FETLQAQAGKHGDDLRNTRNEISEMN--
RAIQRLQAE-I--DNIKN------------------------------------------
-----Q-RA--KLEAAIAEAEE-RGELAL-KDARAKQ----EELEAALQRAKQDMVRQLR
EYQELMSVKLALDIEIATYRKLLEGEE--------------------------S-RLA-G
D-------G--------VGA-----VN---------------------------------
-ISVVNST-GG-----SSNG----------------GGIGLTLGG-----TMGSNALSFS
SS-----AGPGP------------------------------------------------
--------LKAYSIRTTSTSRRSARN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
MA--STSTTIR--SH-SSSRRGFSAGSARLPG-----VSRS-GFSSVS-VSRSRGSGGLG
G-------------------------------AC-----------GGAGFGSRSLYGLGG
S-KRISIGGG----SC--AISGG-------------YGS--RA----GGSYGFGG-A-G-
--------------SGFGFG--GG--A------GI-----------------GF----GL
G--GG-AGLAG-GFGGPGFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPAIQR--VRA EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVRQNL--EPLFE-QYINNLRRQLDSIVG
ERGRLDSELRN-MQDLVEDLKNK-YEDEINKRTT---AENEFVTLK--K---DVDAAYMN
KVELQAKADTLTDEINFLRALYEA-----ELSQMQTHISDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEEIAQ-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEIAEIN--
RMIQRLRSE-I--DHVKK------------------------------------------
-----Q-CV--SLQAAIADAEQ-RGEMAL-KDAKNKL----EGLEDALQKAKQDLARLLK
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLN-G
EG--VG-QV-------N-ISVVQSTV----------------------------------
------------SSGYGGASG-------------------------V-------------
---------------------------------------SSGLGLGGGSS----YS----
-----------------------YGSG--------------LGVG--------------G
GFSSS---SGRAIG--GGLS--SAGGG-SSTIKYT----TTSS-----------------
------------------------------------------------------------
------------SSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

MTSVGVF---------SDRLNRCGKDGLVPRAKPRDVSDFSLYAPATKPCCS--------
------------------------RTYKRPRLRAPALTGLGPL----T---SLIAPSSLS
AAMIARQQCVR-----G-GPRGFSCGSAIVGSG----KRG--AFSSVS---MSGGA----
-----------------------------------------GRCS-SGGFGSRSLYNLGG
K-KSISMSVAGSRQ-GA-CFGGAGG-----------FGT---------------------
---------------------------------------GGFG-----------------
---GGFGG----SFS--GKGGPGFL-VC--PAGGI------QEVTINQSLLTPL----HV
EIDPEIQK--VRTEEREQIKLLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQQQTTTT----SSKNL--EPLFE-TYLSVLRKQLDTLGN
DKGRLQSELKT-MQDSVEDFKTK-YEEEINKRTA---AENDFVVLK--K---DVDAAYMN
KVELEAKVDSLNDEINFLKVLYDA-----ELSQMQTHVSDT----SVVLSMDNNRNLDLD
SIIA-EVRAQYEEIAQ-RSKAEAEALYQTK--VQQLQISVDQHGDNLKNTKSEIAELN--
RMIQRLRAE-I--ENIKK------------------------------------------
-----Q-CQ--TLQASVADAEQ-RGENAL-KDAHSKR----VELEAALQQAKEELARMLR
EYQELMSVKLALDIEIATYRKLLEGEE--------------------------Y-RMS-G
ECQSA---V--------SISVVSGSTSTGG------------------------------
---------------ISG-G---LGS-----------------------------GS---
---GFGL------------------------SSGFGSS--SGSGFGF--G-GS-------
----VSGSSSSKIISTTTLNKRR-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTQKSYK--VS--TSGPQAFYNPAHVSLEY-----KRL-SLLSF-------------
-------------------------------------------------------SRVSS
-----------------------S-----------SFRDV------------LGTSM---
--------------GLCG------------------------------------------
-----------------GYEGP--------AMGGI------TSITVIQNLLSPL----NL
ELDPNMQA--TDTQEKEQIETLN-TFASF------VDK--VR------------------
----FLEQQNK-MPETKWSLLQQ-QKT-----VWSNMFWDNMFE-SYINNLLRQLETRGQ
EKLKLEAEPGN-MQG-LEDFKKK-YEDEINKRTE---MENEFVLVK--K---AVDEAYMN
KGELEFHLEGLTDEISFLRQLYEE-----EIPGLQSQILDT----SVVLSMDNSGSLDMD
SIIA-EVKAQYEEIAN-CSRAEAEIMYQIK--YEELQTLAGKHWDDWRRTKTKIFEMN--
RNISRLQAETEDLPQRPE------------------------------------------
-----Q-RA--SLESAIADTEQ-RGEVAV-KDANAKL----SELEAAQQWANQDMARQLP
EYQELMNGKLVLDIEIATYRKLLEREES---------------------------RLE-F
---GM---Q--------NMSICIYRKTT--------------------------------
------------------------------------------------------------
--------------------------------------------RGSK--------AW--
--------------------------------GS--------SFGSGR---------ASS
SFSRT-------------------SSLRAVVVKTI------KTRDGKLVSESSDVPPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
----------------------FSSRSYTSGPS-----SRI-NFSTL-------------
-------------------------------------------------------SRVGS
S----------------------------------GFRGS------------MGAGL---
--------------GL---G----------------------------------------
---------------LGYGG-AG-------SVGTI------TAVTLNQSLLNPV----KL
MDTNDLQA--VRMQEKEQIKSLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWRLLQQQQKT-----SRSDM--DSLFE-SYISNLRRQLEGLGQ
EKLKLEAELGN-MQGLVEDFKNK-YEEEINKRTD---MENEFVLIK--K---DVDEAYMN
KVELESRLEGLTEEINFLRHLYEA-----ELAELQAQISDT----SVVLSMDNSCSLDLD
GIIA-EVKAQYEEIAN-RSRAEAESMYQIE--YEKLQTLAGKHGDDLRRTKTEITEMN--
RSISRLQAE-I--EGLKG------------------------------------------
-----Q-RA--SLEAAITEAEQ-RGELAV-KDANAKL----AQLEAALQQAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEEG---------------------------RLE-A
---GM---Q--------NMSIHTRTSSS--------------------------------
---------------GY-------------------HSGGLSP-----------------
---V------------------------------------VGLNLGSS--------PF--
---------------------------------Q--------GLASPG---------GSG
L---V-------------------IRNKALVVKKI------ETRDGKLVSESSDVLSN--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQACKT--P--GGRSQGFSGRSAVVSG------GSR-M-SC---VARTG------
-----GG-------------------------ACGLR----SG---AGGFGSHSLYNLGG
H-KSISISVAAGGT-RAGGFGGGHS------VCGGGFGGSYGGALGGGYGGSFGSGFGGS
RG----MGSGFGGAGGFG--------------GA-----GGFSG---------------F
AGFGGFG--------G---PGGFGP-DS--FPGGI------QEVTVNQSLLQPL----NV
EIDPQIGQ--VKA QEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWELLQQQGTSST--TGTNNL--EPLFE-NYINHLRNHLDGILG
DRGRLDLELRN-MQDLVEDFKKK-YEDEINKRTV---AENEFVTLK--K---DVDAAYMN
KVELQANTDALVDEINFLRTLYDA-----ELSQMQRHVSDT----SVILSMDNNRDLDLD
SIIA-EVRGQYEDIAQ-RSKAEAEVLYQTK--LGELQTTAGRHGDDLRSTKSEIQELN--
RMIQRLRAE-I--ENVKK------------------------------------------
-----Q-NA--NLQTSIAEAEQ-RGEMAL-KDANAKL----QDLQAALQQAKDDLARLLR
DYQELMNVKLALDVEIATYCKLLEGEE--------------------------C-RMS-G
ECQSA---I--------SISVVNSSST---------------------------------
--------TSASAGGYVGN-YGGG------------FSVGG-------------------
-----------------------------T---------GTGSGFGLGGG-G--------
-GIGSGGGFGG-----------------------------------SSSF--SGGSSF--
GSGSV--GH-SGVSVGSFRS----GGNRGGTVRFS----QSS------------------
------------------------------------------------------------
----------QRY-SR--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R-V-TQKSYK--VST--SAPRSFSSRSYTSGPG-----SRI-SSSAF-------------
-------------------------------------------------------SC---
----------------------------------------------------LGTGM---
--------------SM---A----------------------------------------
---------------GSYGG-AP-------GLGGI------TAVTVNQSLLSPL----KL
EVDPNIQA--VRTQEKEQIKTLNNKFASF------IDK--VR------------------
----HLEQQNK-VLETKWNLLQQ-QKT-----AQSNI--DNMFE-SYINNLRRQLETLAQ
EKLKLEVELGN-MQGLVEDFKTK-YEDEIQKHTD---MENEFLIIK--K---DVDEAYMN
KVELESRLEGLTDEINFYRQLYEE-----EIHEMQSQISDT----SVVLSMDNNSNLDLD
GIIA-EVKAQYEEIAN-RSRAEAETMYQIK--YEELQTLAGKHGDDLHLTKTEIPEMN--
RNINRLQAE-I--EGLKG------------------------------------------
-----Q-RA--SLEAAIADAEQ-RGEMAV-KDAQAKL----AELEAALRNAKQDMAQQLR
EYQELMNDKLALDVEIATYRKLLEGEES---------------------------RLE-S
---GM---Q--------NMSIHTKTTSG--------------------------------
---------------YAG---------------------GLTS-----------------
---SYG---------------------------------TPGFKYSLS------------
---------------------------------P--------G----------------S
FS--R-------------------TSSKAVVVKKI------ETRDGKLVAESSDVLSK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------M--
----SRQVYKT--S--GGGSRSFSGRSAVAPGRS-SSSSTR-M-SC---VARSAAA-G--
-----SG-------------------------ASGIR----GV---AGGFGSRSLYNLGG
H-KSISMSVAAGGS-QAGGFGGGRS------I--CG----------SGFGGGYGGGFGGG
--S--GMGGGFGGAGAFG--------GAGGFGGA-----GGF------------------
------GGPG--GFGG---P------GG--FPGGI------QEVTVNQSLLQPL----NV
EIDPQIGQ--VRAQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWTLLQQQGTNSI--TGTNNL--EPLFE-NHINYLRSYLDGIIS
ERGRLDSELRN-MQDLVEDFKKK-YEDEINKRTA---AENEFVTLK--K---DVDASYMN
KVDLQAKVDALMDEINLLRTLYDA-----ELSQMQSHVSDT----SVVLSMDNNRNLDLD
SIIA-EVRAQYEDIAQ-RSKAEAEALYQTK--LGELQTTAGRHGDDLRSTKSEIAELN--
RLIQRLRAE-I--ENVKK------------------------------------------
-----Q-NA--SLQSAIADAEQ-RGELAL-KDARAKL----DGLEAALQKAKDDLARLLR
DYQELMNVKLALDIEIATYRKLLEGEE--------------------------CSRMS-G
ECQSA---V--------SISVVNSST----------------------------------
-------TTSAAAGGYGGGFGM-------------G----GGAG----------------
-------------------------------------------GLGRGGG--SGFGSG--
FGGG--------S----------SSSS---------------------GI--RVGSGGGF
GSSSG--GR-SAVSGGGFSS----GSTRGSSVKFS----QSS------------------
------------------------------------------------------------
----------QRY-SR--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
RSTTTRQTVK--VSS--SIPRSFSSRSYSSGPS-----SRI-SSSSF-------------
-------------------------------------------------------SRG--
-----------------------------------SFRPG------------FGRAR---
---------------L---G----------------------------------------
---------------MGF-GGSS-------GVGGI------TEVSVNQSLLNPL----KL
ELDPSIQA--VRTQEKEQIKSLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQQ-QKT-----SQSNL--DGLFE-KYINNLRRQLDSMGQ
EKLKLEVELGN-MQGLVEDFKKK-YEDEINKRTE---RENEFVLIK--K---DVDEAY-N
KVELESRLXXXXXXXXXXXXXXXX-----EIKEMQSQISDT----SVILSMDNNRSLDLD
GIIA-DVRAQYEEIAN-RSRAEAETMYQIK--RASL------------------------
------------------------------------------------------------
--------------KAITDAEQ-RGDLAI-KDARAKL----SELEAA-QRAKQDKARQLR
EYQELMNVKLALDIEIATYRKLLEGEES---------------------------RLE-S
---GM---H--------NMSIHTKTTSR--------------------------------
---------------DYS------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQSSVS--FR-SGGSRAFSTASAVTPS-----VSRI-SFSSV---SRSGGG-GGG
GFGRVS--------------------------LG-------GAGGA-GGYGTRSLYNLGG
S-KRISISAS----GG--GLRNR-------------FGAG--A----GGGYGFGGGA-G-
--------------SGFGFG--GGAGGGF-G-LGG-----------------GA----GF
---------GG-GFGGPGFP------VC--PPGGI------QEVTVNQNLLTPL----NL
QIDPTIQR--VRTEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGNK----TVRQNL--EPLFE-QYINNLRRQLDSVLG
ERGRLDSELRN-MQDLVEDYKNK-YEDEINKRTT---AENEFVMLK--K---DVDAAYMN
KVELEAKVDALMDEINFLKLFFEA-----ELAQMQTHVSDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEDIAN-RSRTEAESWYQTK--YEELQQTAGRHGDDLRNTKHEISEMN--
RMIQRLRAE-I--DNVKK------------------------------------------
-----Q-CA--NLQSAIADAEQ-RGELAL-KDARNKL----AELEDALQKAKQDMARLLR
EYQELMNTKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VG-PV-------N-ISVVTNNV----------------------------------
------------SSSYGGGS-GF--------------------------G----L-----
-----GGGLGGGL--------------------------SSSLGGG-GGG----SYYSS-
-----------------------SS-------GVGLG--GGLGAGG-------------S
GFSTS---SGRSLGVGFGG---GG-G-SSSSVKFV----STTS-S---------------
------------------------------------------------------------
-------------TRKSFK-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
----------------------------------------------------------MA
RRNMSSKTTVR--SQS-SSRRGFSASSARGPG-----LSRS-GFSSVS-VCRSRGSGGIG
A-------------------------------AC-----------GGAGFGSRSLYGLGG
S-KRISIGGG----SC--ATGGG-------------YGS--RI----GGGFGFGGGA-G-
--------------SGFGYG--GG--A------GS-----------------GF----GL
G--GG-AGFGG-GYGGAGFP------VC--PPGGI------QEVTVNQSLLTPL----NL
EIDPTIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVRQNL--EPLFE-QYINNLRRQLDSIQG
ERGRLDSELRS-MQDTVEDYKNK-YEDEINKRTA---AENEFVTLK--K---DVDAAYMN
KTELQAKVDSLVDEINFLRAFYDA-----ELSQMQTHISDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEEIAQ-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEITEIN--
RMIQRLRSE-I--DHVKK------------------------------------------
-----Q-CA--NLQAAIADAEQ-RGELAL-KDARNKL----EGLEDALQKAKQDMARLLK
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLN-G
EG--VG-QV-------N-ISVVQSTV----------------------------------
------------SSGYGSA-------------------------SGM-------------
---------------------------------------GSGVGLGGG-S----SYSY--
------------------------SSG--------------HSLG--------------G
GFSSG---SGRGISTGGGLS--SVGG-STSSIKYT----TS-S-----------------
------------------------------------------------------------
------------SSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R-V-TQKSYK--VSS--SGPRAFSSRSYTSAPG-----ARI-SSSSF-------------
-------------------------------------------------------SRVGS
-----------------------------------SIRGA--------------------
-------------------S----------------------------------------
---------------MGLGAGVG-------GAGGI------TAVTVNQSLLSPL----KL
EVDPNIQA--VRTQEKEQIKSLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQQ-QKT-----ARSNM--DGMFE-SYINNLRRQLDTLGQ
EKLKLEAELGN-MQGLVEDFKNK-YEDEINKRTE---MENEFVLIK--K---DVDEAYMN
KVELESRLEGLTDEINFLRQLYEE-----EIREPQSQIWET----NVNKSMYNSRTLHLG
SMIN-EEGGQYEEIAN-RSRE-AERMYKIK------------------------------
------------------------------------------------------------
-----D-RA--SLEAAIADAEQ-RGELAL-KDAQAKL----AELEAALQRAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEES---------------------------RLE-S
---GM---Q--------NMSIHTKTTTG--------------------------------
---------------YAG---------------------GLSS-----------------
---AYG------------------------------SLASPGLNYGLS--------FQ--
---------------------------------S--------GFGPGG---------SSS
SIT-----------------------RKAVVVKKI------ETRDGKLVSESSDVLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTQKSYR--VST--SGPGAFSSRSFTSGPS-----ARS-SSSSF-------------
-------------------------------------------------------SRVSS
-----------------------A-----------GFRGG------------LGAGY---
--------------AG---A----------------------------------------
---------------S-----GM-------GMGGI------TAVTINQSLLNPI----KL
DVDPNIQA--VRT QEKEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQQ-QKT-----ARSNM--DNMFE-SYINNLRRQLETLGQ
GKLKLEAELGN-MQGLVEDFKNK-YEEEINKRTE---MENEFVLIK--K---DVDEAYMN
KVELESRLEGLTDEINFLRQLYEE-----EIRELQSQISDT----SVVLSMDNSRSLDMD
SIIA-EVKAQYEEIAN-RSRAEAESVYQIK--YEELQKLAGKHGDDLRRTKTEISEMN--
RNISRLQAE-I--EGLKG------------------------------------------
-----Q-RA--SLEAAILDAEH-RGEQAL-KDARAKQ----QQLEEALQQAKQDMARQLR
DYQELMNVKLALDIEIATYRKLLEGEES---------------------------RLE-S
---GM---Q--------NMSIHTKTTSG--------------------------------
---------------YAG---------------------GLSS-----------------
---AYG------------------------------GLTSPGLSYSLG------------
--------------------------------SS---------FGPGG---------GS-
TFSRT-------------------SSTKAVVVKKI------ETRDGRLVSESSDVLSK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
----------------------------------------------------------MR
-SSVSRQTYYT--------KGGFSSNSASGG---GGSQART-SFSSVT-VSRNSGSGGG-
--------------------------A--------------RCGPSTGGFGSRSLYNLGG
H-KSISVSVAGGASSG-WAL----------------------------------------
--------------GGFGFG------------------SRAFT-----------------
-------GQG-------AGRQTFGP-AC--PPGGI------QEVTVNQSLLTPL----HV
EIDPEIQR--VRTQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQGQNLG--VTRNNL--EPLFE-AYLGSMRSTLDRLQS
ERGRLDSELRN-VQDLVEDFKNK-YEDEINKRTA---VENEFVVLK--K---DVDAAYMG
RMDLHGKVGTLTQEIDFLQQLYEM-----ELSQVQTHVSDT----NVVLSMDNNRNLDLD
SIIA-EVKAQYELIAQ-RSRAEAEAWYQTK--YEELQVTAGKHGDNLRDTKNEIAELT--
RTIQRLQGE-V--DAAKK------------------------------------------
-----Q-CQ--QLQTAIEEAEH-RGELAL-KDAQKKL----GDLDVALHQAKEELARLLR
DYQELMNVKLALDVEIATYRKLLESEE--------------------------S-RMS-G
ECPSA---V--------SISVTGNSTTVCG------------------------------
-----------------G---------------------GIALDGN---GG--ATKGGFS
TN----------------------------------------VGYST----------V--
KGGPVSG--GTSILRKT--TTVKTSSRRY-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

VTSVGVF---------SDMFSRCERDGLVPKAKPRDVSDFSLYAPATKPCSS--------
------------------------GTYKRPRLPAAAFTGQEPL----SSLTAPS--SLSS
LAMIARQQCVR-----G-GSRGFSGSSAV-IGG----GKRA-TFSSVS---VSGGA----
-----------------------------------------GRCS-SGGFGSRSLYNLGG
N-KSISMSVAGSRQ-GA-GFGGAGG-----------------------------------
------------------------------------FGAGGFG-----------------
---GGFGG----SFA--GRGGSSFP-VC--PAGGI------QEVTINQSLLTPL----QV
EIDPEIQK--VRTEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQQQTTST----SPKNL--EPYFE-AYLSALRKQLDTLGS
DKGRLQSELKT-MQDSVEDFKTK-YEDEINKRTA---AENDFVVLK--K---DVDAAYMN
KVELEAKVDALNDEINFLRVLYDA-----ELSQMQTHVSDT----SVVLSMDNNRNLDLD
SIIA-EVRAQYEEIAQ-KSKAEAEALYQIK--VQQLQTSVDQYGDNLKTTKSEIAELN--
RMIQRLRAE-I--ENVKK------------------------------------------
-----Q-CQ--TLQASVADAEQ-RGELAL-KDAYSKR----TELEAALQQAKEELARMLR
EYQELMSVKLALDIEIATYRKLLEGEE--------------------------S-RMS-G
EYQNA---V--------SICKYPQPLVGGG------------------------------
---------------AS-VG---AIG----G---GGFS--LG------------------
------G------------------------GFGSGSG--SGFGFGV--G-CG-------
----VGGGSSGKIISTTTLTKR--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQSSVS--FR-SGGSRSFSTASAITPS-----VSRT-SFTSV---SRSGGG-GGG
GFGRVS--------------------------LG-------GACGV-GGYGSRSLYNLGG
S-KRISISTS----GG--SFRNR-------------FGAS--A----GGGYGFGGSA-G-
--------------GGFGFG--GGAG--------G-----------------GF----GL
G--GGA-GFGG-GFGGPGFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPTIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVRQSL--EPLFE-QYINNLRRQLDSIVG
ERGRLDSELRN-MQDLVEDFKNK-YEDEINKRTT---AENEFVMLK--K---DVDAAYMN
KVELEAKVDALMDEINFMKMFFDA-----ELSQMQTHVSDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEEIAN-RSRTEAESWYQTK--YEELQQTAGRHGDDLRNTKHEISEMN--
RMIQRLRAE-I--DNVKK------------------------------------------
-----Q-CA--NLQNAIADAEQ-RGEMAL-KDARNKL----AELEEALQKAKQDMARLLR
EYQELMNTKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VG-PV-------N-ISVVTSSV----------------------------------
------------SSGYGGGS-G--------------LGG--GLGGGLGGG----L-----
-----GGGLGG------------------------------------GST----SYYSS-
------------------------SSG-----GVGLG--GGLSVGG-------------S
GFSAG---SGRGMGIGFGS---GG-G-SGSSVKFV----STTS-S---------------
------------------------------------------------------------
-------------SRKSFKS----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
-------------------SRSFSAASAITPS-----VSRT-SFSSVSRS--GGGGGG--
-FGRVS-----------------------------L----GGVCG-AGGYGSRSLYNLGG
S-NRISISAGGGGF-R-SRFGAGTG-----------------------------------
--------------GGYGFG----GGAGSGFGFGGGAGG-----------------GFGL
GG--------GAGFGG-GFGGAGFP-VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPTIQR--VRTEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTKT----VKQNL--EPLFE-QYINNLRRQLDYLLG
ERGRLDSELRN-MQDLVEDFKNK-YEDEINKRTT---AENEFVMLK--K-----------
-----------------------------ELAQMQTHISDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEEIAN-RSRTEAESWYQTK--YEELQQTAGRHGDDLRNTKHEITEMN--
RMIQRLRAE-I--DNVKK------------------------------------------
-----Q-CA--NLQSAIAEAEQ-RGELAL-KDARNKL----AELEDALQKAKQDMARLLK
DYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG-VGP--V--------NIYISPL-LNTGA------------------------------
------------SSGFGF----GGGA----GFGG-------------------GYG----
---GS-------------------------------------------------------
------------------------------------------------------------
GFPVC--PP-GGIQEV---TVNQ-------NLL---------------------------
------------------------------------------------------------
----------TPL-NLEI----DPTIQRVR--TEEREQIKTLNNKFASFIDKVRFLEQQN
KVLETKWALLQEQGPKT--VTQNLDPLFEQYINNLKRQLETFHVEKGRLDSELRNVQDTL
GDMKKRYEDEINKRTQAENEFVTLKKDVDAAYLNKVDLQAKVDGLSEEINFLRVLYNEEL
SQMQTHISDTSVVLSMDNNRSLDLDSIIAEVKAQYEDIANRSRAEAESWYQTKYEELQVT
AGRHGDDLRNTKQEIAEMNRVIQRLRSEIDHVKKQNANLQASIADAEQRGEMALKDARNK
LESLEDALQKAKQDMAQLLKDYQELLNVKLSLDVEIATYRKLLEGEECR-----------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSR
QSSVS---------FRSGGSRSFSAASAITPS-----VSRT-SFSSVSRS--GGGGGG--
-LSRIS-----------------------------F----GGIGG-LGGYGSRSLYNVGG
S-RKISMSTSGGSF-R-NRFGAGAG-----------------------------------
--------------GGYGFG----GGAGSGFGFGGGAGG-----------------GLGL
GG--------GAGFGG-GYGGAGFP-VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPTIQR--VRTEEREQIKTLNNKFASF------IDK--XX------------------
----XXXXXXX-XXXXXXXXXXXXXXXX----XXXXX--XXXXX-XXXXXXXXXXXXXXX
XXXXXXXXXXX-XXXXXXXXXXX-YEEEINKRTT---AENEFVMLK--K---DVDAAYMS
KVELEAKVDALMDEINFMKMFFDA-----ELSQMQTHVSDT----SVVLSMDNNRNLDLD
SIIS-EVKAQYEEIAN-RSRTEAESWYQTK--YEELQQTAGRHGDDLRNTKHEISEMN--
RMIQRLRAE-I--DNVKK------------------------------------------
-----Q-CA--NLQNAIADAEQ-RGELAI-KDARNKL----AELEEALQKAKQDMARLLR
EYQELMNTKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG-VGP--V--------NI-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRISYR---SSTGGGMRGFSSGSAIVGG-G--SGTRS-SFSSVS-VSRVGGGRA--
-------------------------------------GG-GGGFGAGGGFGSRSLYNLGG
S-KRISLG---GGL-RSG-AGAGYG-----------F--GGGAG--------FGLG----
-------YG--GG-AGAALGLGGAG-GGGGY---------------G--L----G-GFGM
GGP---------GFG--GRGGPGFP--C--PPGGI------HEVTVNQSLLAPL----KL
DIDPEIQK--VRTHEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWSLLQEQGHTV----TRKSL--EPLFE-SYINNLRRQLDSLMG
ERGRLDSELRS-MQDMVEDFKNK-YEDEINRRTG---AENEFVVLK--K---DVDGAYMN
KVELQAKADGLADEINFLRALYEA-----ELSQMQQQVSDT----SVVLSMDNNRSLDLN
SIIA-EVKAQYEDIAN-RSRAEAEAWYQNK--YEELQVSAGRHGDDLRNTKMEISEIN--
RMVQRLRNE-I--ESVKK------------------------------------------
-----Q-CA--SLQAAIAEAEE-RGEMAL-KDAKSKL----AELEDALQKAKADLARQLR
EYQELMNVKLALDIEIATYRKLLEGEE--------------------------S-RLA-G
EGVG-A--V--------SVSVVSSSSGMGY------------------------------
------------GGGMGGGLGMGG-----------GLGMGSGL------G----------
------------------------------------------------------------
----MG----G--------------GGSY-TMSS------SGGGGGFGGGSASYSYGGGS
NFSSS--SS-R-----GV--SS----STGGSVRIV----SKT------------------
------------------------------------------------------------
----------TTS-KKTIR-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSSKTTVR--TQS-SSRRGFSASSARVPG-----LSRS-GFSSVS-VCRSRGSGGIG
A-------------------------------AY-----------GGAGFGSRSLYGLGG
S-KRISIGGG----SC--AIGGG-------------YGS--RV----GGGFGFGGGA-G-
--------------SGF-----------------------------------------GF
G--GG-AGFGG-GYGGAGFP------VC--PPGGI------QEVTINQSLLTPL----NL
EIDPTIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVRQNL--EPLFE-QYINNLRRQLDSILG
ERGRLDSELRN-MQDTVEDYKHK-YEDEINKRTA---AENEFVTLK--K---DVDAAYMN
KTELQTKADSLIDEINFLRTLYEA-----ELAQMQTHISDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEEIAQ-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEIAEIN--
RMIQRLRSE-I--DHVKK------------------------------------------
-----Q-CT--NLQAAIADAEQ-RGELAL-KDARNKL----EGLEDALQKAKQDMARLLK
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLN-G
EG--VG-QV-------N-ISVTQSTV----------------------------------
------------SSGYGGA-------------------------SGM-------------
---------------------------------------GGGVGLGGG-S----GYSY--
------------------------SSG--------------HSLG--------------G
GFSSG---SGRGISIGGGLS--SVGG-STSSIKYT----SS-S-----------------
------------------------------------------------------------
------------SSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTQKSYK--VST--SGPRAFSSRSYTSAPG-----ARI-SSSSF-------------
-------------------------------------------------------SRVGS
G----------------------S-----------SFRGS------------LGTSM---
--------------GL---G----------------------------------------
---------------GFG-GP-G-------VG-GI------TAVTVNQSLLSPL----KL
EVDSNIQA--VRT QEKEQIKSLNNKFASF------IDK--VR------------------
----LLEQQNK-MLETKWSLLQQ-QKT-----SRSNM--DNMFE-SYINNLRRQLEALGQ
EKLKLEAELGN-MQGLVEDFKNK-YEDEINKRTE---MENEFVLIK--K---DVDEAYMN
KVELESRLEGLTDEINFLRQIHEE-----EIRELQSQISDT----SVVLSMDNSRSLDMD
SIIA-EVRAQYEDIAN-RSRAEAESMYQIK--YEELQTLAGKHGDDLRRTKTEISEMN--
RNISRLQAE-I--EGLKG------------------------------------------
-----Q-KA--TLEAAIAEAEQ-RGEMAI-KDANNKL----AQLEAALQQAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEES---------------------------RLE-S
---GM---Q--------NLSIHTKTTSG--------------------------------
---------------YSG---------------------GLNT-----------------
---AYG------------------------------GLTSPGFSYGVSSF-------Q--
--------------------------------PS---------FSSAG---------GSS
TYSRK-----------------------AVVVKKI------ETRDGKLVSESSDILPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------VC--PPGGI------QEVTVNQNLLTPL----NL
EIDPTIQR--VRTEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQGPK----TVTQNL--DSLFE-QYINNLKRQLETFHV
EKGRLDSELRN-VQDTLGDMKKR-YEDEINKRTE---AENEFVTLK--K---DVDAAYLN
KVDLQAKVDGLSEEINFLRVLYNE-----ELSQMQTHISDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEDIAN-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEIAEMN--
RVIQRLRSE-I--DHVKK------------------------------------------
-----Q-NA--NLQASIADAEQ-RGEMAL-KDARNKL----ESLEDALQKAKQDMAQLLK
DYQELLNVKLSLDVEIATYRKLLEGEECR-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--M-SRQSTIT--FQTG-SCRGFSTASATSPA-----TGRS-RFSSVS-VTHSSG--GSG
GL----------------------------------------------------------
------------------------------------------------------------
-----------------GNG--GGIGVGY-------------------------------
--------------GGCGFS------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPNIQR--VRKEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWSLLQEQGTK----TVRQSL--EPFFE-AYITDLRRQLDSITT
ERGRLDAELRT-MQDVVEDFKVR-YEDEINKRTA---AENEFVALK--K---DVDAAYLN
KVDLEAKANSLTDEINFLQMLFEA-----ELCQMQTRVSDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEEIAN-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEISETN--
RMIQRLRAE-I--DNIKK------------------------------------------
-----Q-CA--NLQTAIADAEQ-RGELAL-KDARAKL----VDLEEALQKSKQDMARLLR
EYQELMNIKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VS-PVNIS--------VVTSTV----------------------------------
------------SSGYGGGS--SIA-----------------------------------
---------------------------------------SGSLGLGGGSG----YS-ST-
-----------------------SG-------GHSL--------GG-------------S
SFSNS---SSRGLGG------------SGSSIKFV----STTS-----------------
------------------------------------------------------------
------------SSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------M--
----SRQASKT--S--GGGSQGFSGRSAVVSG------SSR-M-SC---VTRPGVA-G--
-----GG-------------------------AYGFR----SG---AGGFGSRSLYNLGG
N-KSISISVAAGGS-RAGGFGGGRS------S--CGFAGGYGGGFGGGYGGGFGGGFGSV
--R--GMGGGFGGAGGFG--------GAGGFGGA-----SGFGGPGGFGGPGGFGGPGSF
GSPGGF---------G---P------GG--FPGGI------QEVTINQSLLQPL----NV
EIDPQIGQ--VKAQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQQQSTSSI--SGTNNL--EPLFE-NHINYLRSYLDNILG
ERGRLDSEMRN-MQDLVEDFKKK-YEDEINKRTA---AENEFVTLK--K---DVDGAYMN
KVELQAKVDALIDEINFLRTLYDA-----ELSQMQSHISDT----SVVLSMDNNRSLDLD
SIIA-EVRAQYEDIAQ-RSKAEAEALYQTK--LGELQTTAGRHGDDLRNTKSEIIELN--
RMIQRLRAE-I--ESIKK------------------------------------------
-----Q-NA--NLQTAIVEAEQ-RGEMAL-KDANAKL----QELQAALQQAKDDLARLLR
DYQELMNVKLALDVEIATYRKLLEGEE--------------------------Y-RMS-G
ECPSA---V--------SISVVSSST----------------------------------
--------TSASAGGYAGGYGG-------------GVGGGLGGGL---------------
--------------------GA----GGG-----------SSSGFGRGGG--GGIGG---
---GIGG-------------------S--------------------SGG--F-SGGSGF
GSSSG--AR-YGVSGGGFSS----ASNRGGSIKFS----QSS------------------
------------------------------------------------------------
----------QSS-QRYSR-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------MQ--VRREEHEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNQ-LLETKWALLQEQGSP-----KSSRL--PSILE-AQVAGLRGQLEALQV
DGGRLEAELRD-MQDAVEDFKNK-YEDEINHRTA---AENEFVVLK--K---DVTRLHE-
QGGAGDQGGALNDEINFLRALNEQ-----EIRELQSQISDM----SVVLSMDNNRSLDLD
SIIA-EVRAQYEDIAQ-RSKAEAESVYQTK--VETLQAQAGKHGDDLRSTRNEISEMS--
RAVQRLQAE-L--DGVKN------------------------------------------
-----Q-RA--RLEAAIADAEQ-RGELAL-QDARAKQ----AELEEALQRAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEE--------------------------S-RVS-G
SEPGP---Y--------SLSDLMEV-----------------------------------
-----------------TPG----------------GPSKLFVWG-----TMGSNALSFS
SA-----GGPGT------------------------------------------------
--------LKA-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VIQKSYK--VS--ISGPGAFSSRSFMSGPS-----ARL-SF----------------
--------------------------------------------------------SR-V
S---------------------SS-----------GFQGG------------LGAGY---
--------------AG--------------------------------------------
-------------------ASGK-------GMGGI------TAVTINQRLLNPI----KM
DVDPNIQA--VCT QEKEQIETLN-KFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQQ-QKM-----ARSNM--D-MFE-SYINNLRRQLETLGQ
EKLKLEAEL-----GLVEDFKNK-YEEEINKRTE---MENEFVLIK--K---DVDEAYMN
KVELESHLEGLTDEINFLRQLYEE-----EIRELQSQTSDT-------------RSLDMD
SIIA-EVKAQYEEIAN-RSWAE-----QIK--YEELQMLAEKHGDDLRRKKTEITEMN--
RNISRLQAE-I--EGLKG------------------------------------------
-----Q-RA--SLEATILDAEE-CGNRAV-KDAHTKQ----KELETALQRAKQDMARQLR
EYQELKNIKLALDIEITTYHKLLEGEES---------------------------RLE-S
---GI---Q--------NMSIHTKTSSS--------------------------------
---------------YAR---------------------GLSS-----------------
---ACG------------------------------GLTSPSLSYGLG------------
---------------------------------S--------S---------------SS
SVSRT-------------------SSTKAVVVKKI------ETRDGRLVSESSDVLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MISRQSSVR-----G-VSRGFSSGSAV-AGG----VKRV-AFSSAS---MSGGA----
-----------------------------------------GRCS-SGGFGSRSLYNLGG
H-KSISMSVAGSCQ-GG-GYGGAGG-----------FGVGG-------------------
----------------YG----------------AGFGAGGFG-----------------
---GGFGG----SFN--GRGGPGFP-VC--PAGGI------QEVTINQSLLTPL----QV
EIDPEIQK--IRTA EREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQQQTTTT----SPRNL--DPFFE-TYINALRKNLDTLSN
DKGRLQSELKL-MQDSVEDFKTK-YEEEINKRTA---AENDFVVLK--K---DVDAAYMI
KVELEAKMESLKDEINFMRVLYEA-----ELSQMQTHVSDT----SVVLSMDNNRNLDLD
GIIA-EVRAQYEEIAR-KSKAEVESWYQIK--VQQLQMSADQHGDSLKSTKNEISELN--
RMIQRIRSE-I--ENIKK------------------------------------------
-----Q-----TLQASVADAEQ-RGELAL-KDAYTKR----ADLETALQKAKEDLARLMR
DYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RMS-G
ECKSA---V--------SISVVGGSASIGG------------------------------
------------------------S---------------------------GGIGL---
---GLGS------------------------GFGSGSC--SGSGFGF--G-GG-------
----IYGSSGTKITSSATIT--KRSPRTR----Q------DPDG--LQP-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

MTSVGVF---------SDK--RYKKDGLLPKTQPRDVLDFSFYAPATKAKCS--------
------------------------STYKSPEQRSSFTGSGLIP----SLVASSLKVFSSP
PAMIV------KPQGIRGTSRGFSSGSAVVGG-----SRRA-AFSSVS-VFG--GG----
-----------------------------------------GRCSASGGFGSKSLYNFGK
N-RCI-SI-AGGR--QGAGFGGA---------------------------GG--------
------------------------------------FGAGGYGGGFG-------------
----------G-AFN--GQGGSNF--LC--PAGGI------QEVTVNQSLLTPL----HL
EIDPEIQK--VRTEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQQQTITT----SSKSL--EPYFE-TFLSCLRKKLDTLLN
DKSRLQSELKS-MQDSVEDFKRX-XXXXXXXXXX---XXXXXXXXX--X---DVDAAYMN
KVELQAKVDAQNDEINFLRVLYEM-----ELSQMQTHVSDT----SVVLSMDNNRSLDLN
SIIA-EVQAQYEDIIQ-KSKAEAQSLYQIK--VQQLQNSVDLHGNSLKNTKNEILELN--
RMIQRLRAE-I--ENVKK------------------------------------------
-----Q-CQ--TLQTSVADAEQ-RGELAL-KDALTKE----TELQGALRKAKEEMNRLLR
EYQELMNVKLALDLEIATYRKLLEGEE--------------------------C-RMS-G
ECQS-A--I--------SISVVGGSVSSGA------------------------------
------------YG------------------------------------------GGFG
GHSGLGLGSG--------------LGGGLGSG----------------------------
-----------------------------------------------------------S
SFGI--------------------G-GGSSSTKIV----SSS------------------
------------------------------------------------------------
----------SLM-KRTSR-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MNRQVCKM--S--GGGSQGFSGRSAVVS-G-----SSR-M-SC---VARSGGA-G--
-----GG-------------------------ACGLR----GGA---GGFGSRSLYSLGG
N-KSISISVAG-GS-RAGGFGGGRS------SCG----SGFGGG----YGGGFGGGFGGG
--R--GMGGGFG-------------------------------GAGGFGGAGGFG-PGGF
GGAG-----------G---F------GG--FPGGI------QEVTVNQSLLQPL----NV
EIDPQIGQ--VKTQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWELLQQQTTGSG--SGPNNL--EPFFE-SYISFLRRQLDLALG
ERGNLEGELKN-MQDLVEDFKKK-YEDEINKRNA---AENEFVGLK--K---DVDAAYMN
KVELQAKVDSLMDELNFLRTLYEM-----ELSQMQSHVSDT----SVVLSMDNNRCLDLD
SIIA-EVKAQYEDIAQ-RSKAEAEALYQTK--LGELQTTAGRHGDDLKNTKSEIMELN--
RVIQRLRAE-I--ENVKK------------------------------------------
-----Q-NA--NLQAAIAEAEQ-RGELAL-KDANAKL----QGLQTALQKAKDDLARLLK
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RMS-G
ECQSA---V--------SISVVSNVTST--------------------------------
---------SGGS------------------S--GGYRGGGSSGS---------------
----------------------------SR---------GSSGGYGGLSG-SG---YG--
VSGGRGGGYQS-------------G--------------------SGGSRS---VSQSGI
GSGSG--GV-QTSGSSGYRS----GSGGSARIRFS----QTT------------------
------------------------------------------------------------
----------SSS-QHCSK-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MIARQQSVR-----G-ASRGFSSGSAI-ASG----VKRV-AFSSAS---MSGGA----
-----------------------------------------GRCS-SGGFGSRSLYNLGG
H-KSISMSVAGSCQ-GG-GYGGAGG-----------FGIGGFG-----------------
-------------AG-FG----------------AGGFG---------------------
---GGFGG----SFN--GRGGPGFP-VC--PAGGI------QEVTINQSLLTPL----QV
EIDPEIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQQQTTTT----SPRSL--DPFFE-TYINALRKHLDSLIN
DKGRLQSELKL-MQDSVEDFKTK-YEDEINKRTA---AENDFVVLK--K---DVDAAYMI
KVDLEAKMDSLKDEINFLRVLYEA-----ELSQMQTHVSDT----SVVLSMDNNRNLDLD
SIIA-EVRAQYEEIAQ-RSKAEVESWYQTK--VQQLQISADQHGDNLKSTKNEISELN--
RMIQRLRAE-I--ENIKK------------------------------------------
-----Q-CQ--NLQTSVADAEQ-RGQTAL-QDAYSKR----AELENALSKAKEDLARLLR
DYQALMNVKLALDVEIATYRKLLEGEE--------------------------C-RMS-G
ECQSA---V--------SISVVGGSASIGG------------------------------
---------------SAGIG---GS---------------------------AGIGL---
---GLGG------------------------GFGSGSG--SGSGFGF--G-GG-------
----VYGSSGTKITSTTTVT--KRSQR---------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------MS----TR
VTQKSFKA--VRMQEKEQIKSLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWRLLQQQQKT-----SRSDM--DSLFE-SYISNLRRQLEGLGQ
EKLKLEAELGN-MQGLVEDFKNK-YEEEINKRTD---MENEFVLIK--K---DVDEAYMN
KVELESRLEGLTEEINFLRHLYEA-----ELAELQAQISDT----SVVLSMDNSRSLDLD
GIIA-EVKAQYEEIAN-HSRAEAESMYQIE--YEKLQTLAGKHGDDLRRTKTEITEMN--
RSISRLQAE-I--EGLKG------------------------------------------
-----Q-RA--SLEAAITEAEQ-RGELAV-KDANAKL----AQLEAALQQAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEEG---------------------------RLE-A
---GM---Q--------NMSIHTRTSSS--------------------------------
---------------GY-------------------HSGGLSP-----------------
---V------------------------------------VGLNLGSS--------PF--
---------------------------------Q--------GLASPG---------GSG
L---V-------------------IRNKALVVKKI------ETRDGKLVSESSDVLSN--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
H-------------F---SSPVFTSRSAAFSGR----GAQV-RLSSA----RPGG-----
----------------------------------------------LG-S--SSLYGLG-
------------AS-RPRVAV--RS-----------------------------------
---------------AYG------------------------------------------
----------------G-------P-----VGAGI------REVTINQSLLAPL----RL
DADPSLQR--VRQ EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-LLETKWTLLQEQKSA-----KSSRL--PDVFE-AQIAGLRGQLEALQV
DGGRLEAELRS-MQDVVEDFKNK-YEDEINRRTA---AENEFVVLK--K---DVDAAYMS
KVELEAKVDALNDEINFLRTLNEM-----ELTELQSQISDT----SVVLSMDNSRSLDLD
SIIA-EVKAQYEEMAK-CSRAEAEAWYQTK--FETLQAQAGKHGDDLRNTRNEISEMN--
RAIQRLQAE-I--DNIKN------------------------------------------
-----Q-RA--KLEAAIAEAEE-RGELAL-KDARAKQ----EELEAALQRTKQDMVRQLR
EYQELMSVKLALDIEIATYRKLLEGEE--------------------------S-RLA-G
D-------G--------VGA-----VN---------------------------------
-ISVVNST-GG-----SSNG----------------GGIGLTLGG-----TMGSNALSFS
SS-----AGPGP------------------------------------------------
--------LKAYSIRTTSTSRRSARN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MIAKQQYVR-----S-GSRGFSGGSAI-VGG----GKRV-AFSSAS---MSGGA----
-----------------------------------------GRYC-SGGFGSRSLYNLGG
H-KSISMSVAGSCQ-GG-GFGGAGG-----------FGTGSF------------------
-----------------G----------------AGYGAGGFG-----------------
---GGFGG----FIN--GRGGPGFP-AC--PAGGI------REVTINQSLLTPL----HV
EIDSDIQK--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQQQTTVT----SPRNL--DTFFE-TYLSALRKHLDSLTN
DKGRLQSELKL-MQDSVEDFKAK-YENEINKRTA---AENDFVVLK--K---DVDAAYMA
KVELEAKVDNLNDEINFLKVLYEA-----ELSQMQTHVSDT----SVVLSMDNNRNLDLD
GIIA-EVRAQYEEIAQ-RSKAEAESWYQTK--VQQLQISVDQHGDNLKSTKNEISELN--
RMIQRLRAE-I--ENIKK------------------------------------------
-----Q-CQ--TLQTSVADAEQ-RGEAAL-KDAYSKH----AELEGALQKAKEEMARMLR
DYQALMNVKLALDVEIATYRKLLEGEE--------------------------C-RMS-G
ECQSA---V--------SISVVGGNISTGG------------------------------
-------------------------------------------------------GV---
---GIGL------------------------GSGFSSA--SGSGFGL--G-GG-------
----VYGSSGSKTVSTTTTTMTKKSQR---------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSSKSIRK--SQ-TITHRGFSAGSARLPG-----AGRS-GFSSIS-VSRSRGSGGLG
G-------------------------------VC-----------GGAGFGSRSLYNLGG
S-KRISIGGG----SC--AISGG-------------YGG--RV----GGGFGFGGGA-G-
--------------SGFGFG--GG--A------GA-----------------GF----GL
G--GG-AGFVG-GYGGSGFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPTIQR--VRTEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVRQNL--EPLFE-QYINNLRRQLDSILG
ERSRLDSELRG-MQDLVEDFKNK-YEEEINKRTA---AENEFVTLK--K---DVDAAYMN
KVELQAKVDSLTDEINFLRAFYDA-----ELAQMQTHISDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEEIAQ-RSRAEAESWYQSK--YEELQVTAGRHGDDLRNTKQEISEIN--
RMIQRLRSE-I--DHVKK------------------------------------------
-----Q-CA--NLQTAIADAEQ-RGEMAL-QDAKNKL----AGLEDALQKAKQDMARLLK
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VG-QV-------N-ISVVQSTV----------------------------------
------------SGGYGG-------------------------SSSV-------------
---------------------------------------GGGVGLGGGSS----YS----
-----------------------YGSG-----IGGIG--G--------------------
GFSSS---SGRGIG--GGFS--STGGG-SSTIKYT----TTS--T---------------
------------------------------------------------------------
------------SSRKSYQH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQTYS---TRAGGGGRSYSAASAIVPG-----GSRA-GFSSVS-VVRSGGGGG--
G-----------------------------FGRLLGGGGGGGGGSGGGGFGSRSLYSLGG
S-KRISFGV-GSSF-RSA-FGGGGSGLGGGSSGGFGLGGGGGGG-----GLGLGLGGG--
-----------GGGGGLGLGLGGGGGGGGGYGFGGGPGGLGFGG----------------
--AGGMGGL-G-GLGG-GRGPMGF--GGPPGMGTI------QEVTVNQSLLAPL----NL
EIDPNIQQ--VRK EEKEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWTLLQDQGQKNS--TGKNNL--DPLFE-AYINNLKRQLANLLS
ERGRMDGELKN-MQDLVEDFKNK-YEEEINRRTA---AENEFVVLK--K---DVDAAYMN
KVELEAKVDALTDELNFLRALYEA-----ELAQLSAQASDT----AVILSMDNNRDLDLS
SIIA-EVKAQYEDIAN-RSRAEAEAWYQTK--YEELQATAGKHGDDLRNTKGEISELN--
RLIQRIRAE-I--ENTRN------------------------------------------
-----Q-CA--TLQTAIGDSEE-RGELAL-KDAKAKM----MELEDALQKAKADMARQLR
EYQELMNVKLALDIEIATYRKLLEGEE--------------------------S-RLS-G
EGLN-P--I--------GYSVISSSSGTAG------------------------------
------------G---GGGF---GGL----SL--------SGG------GGGGGFGLGGG
GGSGYSLGGGGGSGYGLGGGGGSGFSLGGGGGSGFSLGGGGGSGLGLGGG-GGGYSFGSG
GGLGLG---GG-----------GGLGGGY-GGGS------GLGLGGGSSGSGLSSAG--G
NFSS--------------GSAK----GTNPGVKIV----SKT------------------
------------------------------------------------------------
----------SSS-KKSIKSQSLKNASQP--------------------------E----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
----------------------------------------------------------MK
-SSVSQQMYST--------KGGFSSNSASGG---GGSRAHT-SFSSVT-VSRSSGSGGS-
--------------------------A--------------RCGPSMAGFGSRSLHNLGG
S-KSISVSVAGGASSG-RAL----------------------------------------
--------------GGFGFG------------------SRAYS-----------------
-------GLG-------AGRQMFGP-AC--PPGGI------QEVTVNQSLLTPL----NV
EIDPEIQR--VRTQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQGQSSG--VTRNNL--EPLFE-NYLGSLRRQLDTLQS
ERGRLDSELRN-VQDQVEDFKNK-YEDEINKRTA---AENEFVVLK--K---DVDAAYMG
RMDLHGKVGTLSEELDFLNHLYDL-----ELSQVQTHVSDT----NVILSMDNNRSLDLD
SIIS-EVKAQYELIAQ-RSRAEAEAWYQTK--YEELQVTAGKHGDNLRDTKNEISELT--
RTVQRLQSE-V--DAAKK------------------------------------------
-----Q-CQ--QLQTAIVEAEQ-RGDLAL-KDAQKKL----GDLDMALHQSKEDLARLLR
DYQALMNVKLALDVEIATYRKLLESEE--------------------------S-RMS-G
ECPSA---V--------SISMTGSSNTVCG------------------------------
-----------------GG--------------VAGFGGGISLGGS---GG--ASKGGFS
TK----------------------------------------VGYST----------V--
KGVPVSG--GTSILRKT--TTVKTSSRRY-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
H-------------L---SSQVFSSRSAAFPGR----GTQV-RLSSV----RPGG-----
----------------------------------------------FS--S-SSVYGLG-
------------AS-RPRVAV--RS-----------------------------------
---------------AYG------------------------------------------
----------------G-------P-----VGAGI------REVTINQSLLAPL----RV
DIDPSIQQ--VRQEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-LLETKWALLQEQKSA-----KSSRL--PGIFE-AHIAGLQRQLEGLQL
DGGRLEVELRN-MQDVVEDLKNK-YEDEINRRTA---AENEFVVLK--K---DVDAAYMS
KVELEAKVDSLNDEINFFKSLYET-----ELAELQSQISDT----SVVLSMDNNRSLDLD
GIIA-EVKAQYEEMAN-RSRAEAETMYQIK--LETLQAQAGKHGDDLRNTRNEIAEMN--
RAIQRLQAE-I--DNIKN------------------------------------------
-----Q-RA--KLEAAIAEAEE-RGELAL-KDGHAKQ----EELEAALQRAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEE--------------------------S-RLGLG
FGAGS---F--------SLGNASTCGLG-----------------------------SAS
GPARLLPP-GADSSALQTGA----------------PGGGCALCG-----SLAC-----L
GG-----LGCRG------------------------------------------------
--------TRGY------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

-----------------------------------------------------MNGVSWS
------------------------------------QDLQEGISAWFGPPASTPASTMSI
R--VTQKSYK--VST--SGPRAFSSRSYTSGPG-----SRI-SSSSF-------------
-------------------------------------------------------SRVGS
S----------------------------------SFRSG------------LGGGY---
------------------------------------------------------------
-------------------GGAS-------GMGGI------TAVTVNQSLLSPL----VL
EVDPNIQA--VRT QEKEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQQ-QKT-----ARSNM--DNMFE-SYINNLRRQLETLGQ
EKLKLEAELGN-MQGLVEDFKNK-YEDEINKRTE---MENEFVLIK--K---DVDEAYMN
KVELESRLEGLTDEINFLRQLYEE-----EIRELQSQISDT----SVVLSMDNSRSLDMD
SIIA-EVKAQYEDIAN-RSRAEAESMYQIK--YEELQSLAGKHGDDLRRTKTEISEMN--
RNISRLQAE-I--EGLKG------------------------------------------
-----Q-RA--SLEAAIADAEQ-RGELAI-KDANAKL----SELEAALQRAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEES---------------------------RLE-S
---GM---Q--------NMSIHTKTTSG--------------------------------
---------------YAG---------------------GLSS-----------------
---AYG------------------------------GLTSPGLSYGLG------------
--------------------------------SS---------FGSGA---------GPS
SFSRT-------------------SSSRAVVVKKI------ETRDGKLVSESSDVLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--MT-KSYK--V---SSVPRAFSSRSYTSAPG-----ARI-SSSSF-------------
-------------------------------------------------------SRVGS
S---------------------SS-----------SFRSG------------LGSGM---
--------------SLVG------------------------------------------
-----------------GYGGLG-------SAGGI------TAVTVNQSLLTPI----KL
EVDPNIQV--VRTQEKEQIKTLNNKFASF------IDK--VR------------------
----HLEQQNK-ILETKWSFLQQ-QKT-----ARSNM--DNMFE-SYINNLRRQLDALGQ
EKLKLEVELGN-MQGLVEDFKNK-YEDEINKRTE---KENEFVLIK--K---DVDEAYMN
KVELESRLEGLTDEINFFRQLYEE-----EIRELQSQISDT----SVVLSMDNNRSLDLD
GIIA-EVKAQYEDIAN-RSRLEAEFMYQIK--YEELQTLAGKHGDDLRRTKTEISETN--
RNINRLRAE-I--DGLKG------------------------------------------
-----Q-RS--SLVRVVIM--P-CGVLGE-KSVQGI-AFSLSWMELVREREGKRRGRRPP
DMCSYLA-YSLTDVEIATYRKLLEGEES---------------------------RLE-S
---GM---Q--------NLSIHTKTS-S--------------------------------
---------------YSG---------------------GLSS-----------------
---TT-FG----------------------------GLTSPGLSYGLS--------SF--
--------------------------------QS--------SFSSGG---------SSG
PIKLI-------------------GPPSAIVVKKI------ETRDGKLVSESSDILPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
MA--STSTTIR--SH-SSSRRGFSASSARLPG-----VSRS-GFSSVS-VSRSRGSGGLG
G-------------------------------AC-----------GGAGFGSRSLYGLGG
S-KRISIGGG----SC--AISGG-------------YGS--RA----GGSYGFGG-A-G-
--------------SGFGFG--GG--A------GI-----------------GF----GL
G--GG-AGLAG-GFGGPGFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPTIQR--VRA EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWTLLQEQGTK----TVRQNL--EPLFE-QYINNLRRQLDSIVG
ERGRLDSELRG-MQDLVEDFKNK-YEDEINKRTA---AENEFVTLK--K---DVDAAYMN
KVELQAKADTLTDEINFLRALYDA-----ELSQMQTHISDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEEIAQ-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEIAEIN--
RMIQRLRSE-I--DHVKK------------------------------------------
-----Q-CA--NLQAAIADAEQ-RGEMAL-KDAKNKL----EGLEDALQKAKQDLARLLK
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLN-G
EG--VG-QV-------N-ISVVQSTV----------------------------------
------------SSGYGGASG-------------------------V-------------
---------------------------------------GSGLGLGGGSS----YS----
-----------------------YGSG--------------LGVG--------------G
GFSSS---SGRAIG--GGLS--SVGGG-SSTIKYT----TTSS-----------------
------------------------------------------------------------
------------SSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
H-------------F---SSPVFTSRSAAFSGR----GAQV-RLSSA----RPGG-----
----------------------------------------------LG-S--SSLYGLG-
------------AS-RPRVAV--RS-----------------------------------
---------------AYG------------------------------------------
----------------G-------P-----VGAGI------REVTINQSLLAPL----RL
DADPSLQR--VRQ EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-LLETKWTLLQEQKSA-----KSSRL--PDVFE-AQIAGLRGQLEALQV
DGGRLEAELRS-MQDVVEDFKNK-YEDEINRRAA---AENEFVVLK--K---DVDAAYMS
KVELEAKVDALNDEINFLRTLNEM-----ELTELQSQISDT----SVVLSMDNSRSLDLD
SIIA-EVKAQYDEMAK-CSRAEAEAWYQTK--FETLQAQAGKHGDDLRNTRNEISEMN--
RAIQRLQAE-I--DNIKN------------------------------------------
-----Q-RA--KLEAAIAEAEE-RGELAL-KDARAKQ----EELEAALQRAKQDMVRQLR
EYQELMSVKLALDIEIATYRKLLEGEE--------------------------S-RWK-G
D-------P--------SRAPISCVPL---------------------------------
-LSVVNST-GG-----SSNG----------------GGIGLTLGG-----TMGSNALSFS
SS-----AGPGP------------------------------------------------
--------LKAYSIRTTSTSRRSARN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
----------------------------------------------MFRGTRDDFCILDG
S-------------H---SDRGFARRDNLASS----------------------------
------------------------------------------------------------
-----------------LGQL---------------------------------------
---------------RSD------------------------------------------
----------------S-------T-----VGAGI------REVTINQNLLAPL----RS
KIDPSIRQ--VRL EEREQIKILNNKFASF------IDK--VQ------------------
----FLEQQNK-MLETKWALLQEQKSA-----KSSSL--PRVFE-AQIASLRGQLEKLQL
DRGCLEAELRS-MQDVVEDFKNK-YEEETNHRMA---AENEFVVLK--K---DVDTIYMN
KVDLQAKVDSLSDEINFLKTLNEM-----ELAELQSQISDT----SVVLSMDNNRSLDMD
SIIA-EVKAQYEEMAN-RSRTEAEALYQKK--FEILQAQSGKHGENLRNTRNEIVELN--
RAIQRLQAE-I--DNIKN------------------------------------------
-----Q-HA--KLEASIPEAEE-HGELAL-KDAHAKQ----KELEAALQQAKQDIARQLR
EYQELMNIKLALDMEIATYRKLLEGEE--------------------------S-RLS-G
DGVAA---A--------NISV---------------------------------------
----VNSS-G---------G----------------GGRGLVFGG-----TMGSNALRFS
S------GGPGA------------------------------------------------
--------VKAYSIRTTSTTRESTHY----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQSSVS--FR-SGGSRSFSTASAITPS-----VSRT-SFTSV---SRSGG--GGG
GFGRVS--------------------------LG-------GACGV-GGYGSRSLYNLGG
S-KRISISTS----GG--SFRNR-------------FGAG--A----GGGYGFGGGA-G-
--------------SGFGFG--GGAG--------G-----------------GF----GL
G--GGA-GFGG-GFGGPGFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPSIQR--VRTEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVRQNL--EPLFE-QYINNLRRQLDSIVG
ERGRLDSELRN-MQDLVEDFKNK-YEDEINKRTT---AENEFVMLK--K---DVDAAYMN
KVELEARVDALMDEINFMKMFFDA-----ELSQMQTHVSDT----SVVLSMDNNRNLDLD
SIMA-EVKAQYEEIAN-RSRTEAESWYQTK--YEELQQTAGRHGDDLRNTKHEISEMN--
RMIQRLRAE-I--DNVKK------------------------------------------
-----Q-CA--NLQNAIADAEQ-RGELAL-KEARNKL----AELEEALQKAKQDMARLLR
EYQELMNTKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VG-PV-------N-ISVVTSSV----------------------------------
------------SSGYGGGS-G--------------YGG--GLGGGLGGG----L-----
---------GGGL--------------------------GSGLG-GGGSG----SYYSS-
------------------------SSG-----GVGLG--SGLSVGG-------------S
GFSAS---SGRGLGVGFGS---GG-G-SSSSVKFV----STTS-S---------------
------------------------------------------------------------
-------------SRKSFKS----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
MA--STSTTIR--SH-SSSRRGFSAGSARLPG-----VSRS-GFSSVS-VSRSRGSGGLG
G-------------------------------AC-----------GGAGFGSRSLYGLGG
S-KRISIGGG----SC--AISGG-------------YGS--RA----GGSYGFGG-A-G-
--------------SGFGFG--GG--A------GI-----------------GF----GL
G--GG-AGLAG-GFGGPGFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPAIQR--VRA EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWTLLQEQGTK----TVRQNL--EPLFE-QYINNLRRQLDSIVG
ERGRLDSELRG-MQDLVEDFKNK-YEDEINKRTA---AENEFVTLK--K---DVDAAYMN
KVELQAKADTLTDEINFLRALYEA-----ELSQMQTHISDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEEIAQ-RSRAEAESWYQSK--YEELQVTAGRHGDDLRNTKQEIAEIN--
RMIQRLRSE-I--DHVKK------------------------------------------
-----Q-CA--SLQAAIADAEQ-RGEMAL-KDAKNKL----EGLEDALQKAKQDLARLLK
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLN-G
EG--VG-QV-------N-ISVVQSTV----------------------------------
------------SSGYGGASG-------------------------V-------------
---------------------------------------GSGLGLGGGSS----YS----
-----------------------YGSG--------------LGVG--------------G
GFSSS---SGRAIG--GGLS--SVGGG-SSTIKYT----TTSS-----------------
------------------------------------------------------------
------------SSRKSYRH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
MA--STSTTIR--SH-SSSRRGFSAGSARLPG-----VSRS-GFSSVS-VSRSRGSGGLG
G-------------------------------AC-----------GGAGFGSRSLYGLGG
S-KRISIGGG----SC--GISGG-------------YGS--RA----GGSYGFGG-A-G-
--------------SGFGFG--GG--A------GI-----------------GF----GL
G--GG-AGLAG-GFGGPGFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPAIQR--VRAEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWTLLQEQGTK----TVRQNL--EPLFE-QYINNLRRQLDSIVG
ERGRLDSELRG-MQDLVEDFKNK-YEDEINKRTA---AENEFVTLK--K---DVDAAYMN
KVELQAKADTLTDEINFLRALYEA-----ELSQMQTHISDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEEIAQ-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEIAEIN--
RMIQRLRSE-I--DHVKK------------------------------------------
-----Q-CA--NLQAAIADAEQ-RGEMAL-KDAKNKL----EGLEDALQKAKQDLARLLK
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLN-G
EG--VG-QV-------N-ISVVQSTV----------------------------------
------------SSGYGSASG-------------------------V-------------
---------------------------------------GSGLGLGGGSS----YS----
-----------------------YGSG--------------LGVG--------------G
GFSSS---SGRAIG--GGLS--SVGGG-SSTIKYT----TTSS-----------------
------------------------------------------------------------
------------SSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
----------------------------------------------------------MR
-SSVSRQTYST--------KGAFSSSSASGG---GGSRART-SFSSV-------------
---------------------------------------------TMGGFGSRSLYNLGG
S-KSISVNMAGGASAG-RVL----------------------------------------
--------------GGFGLG------------------GGAYM-----------------
-------GLG-------AGR-LLGP-VC--PPGGI------QQVTINQSLLTPL----HV
EIDPEIQR--VRTEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQGQKSG--VTRNNL--EPLFE-SFINNLRGKLDNLQS
ERGRLDSELRN-VQDLAEDFKTK-YEDEINKRTA---AENEFVVLK--K---DVDAAYMG
RMDLHGTVDRLVEEMDFLRHLYEE-----ELSQMQTHVSDT----SVILSMDNNRNLDLD
SIIA-EVKAQYELIAQ-RSRAEAESWYQTK--YEELQVTAGKHGDNLRDTKNEIAELT--
RTVQRLQGE-A--DAVKK------------------------------------------
-----Q-CQ--QLQTAITDAEQ-RGELAL-KDAQKKL----GDLDAALYQAKEDLARLLR
DYQALMNVKLALDVEIATYRKLLESEE--------------------------S-RMS-G
ECPSA---V--------SISVTGNSTTVCG------------------------------
-----------------GG--------------VAGFGGGISLGGG---GGAGASKGRFS
TN----------------------------------------AGYST----------V--
KGGPVSG--GTSILRKT--TTVKTSSRRY-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQSSVS--FR-SGGSRSFSAASAITPS-----VSRT-SFTSV---SRSGG--GGG
GFGRVS--------------------------LG-------GAYGG-GGYGSRSLYNLGG
S-KRISISTS----GG--NFRNR-------------FGAG--A----GGGYGFGGGS-G-
--------------SGFGFG--GGAGG-------G-----------------GF----GL
G--GGA-GFGG-GFGGPGFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPAIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTK----TVRQNL--EPLFE-QYINNLRRQLDSILG
ERGRLDSELRN-MQDLVEDFKNK-YEDEINKRTT---AENEFVMLK--K---DVDAAYMN
KVELEAKVDALMDEINFMKMFFDA-----ELSQMQTHVSDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEEIAN-RSRTEAETWYQTK--YEELQQTAGRHGDDLRNTKHEISEMN--
RMIQRLRSE-I--DNVKK------------------------------------------
-----Q-CA--NLQNAIADAEQ-RGELAL-KDARNKL----AELEDALQKAKQDMARLLR
EYQELMNTKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VG-PV-------N-ISVVTSSV----------------------------------
------------SSGYGSGG-G--------------YGG--GLGGGLGGG----L-----
-----GGG----------------------------------LG-GGGSG----SYYSS-
-----------------------SS--------GGMG--SGLSVGG-------------S
GFSAG---SGRGLGVGFGS---GG-G-SSSSVKFV----STTS-S---------------
------------------------------------------------------------
-------------SRKSFKS----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
----------------------------------------------------------MR
-SSVSRQTYYT--------KGGFSSNSASGG---GGSQART-SFSSVT-ASRNRGSGGG-
--------------------------A--------------RCGPSTGGFGSRSLYNLGG
H-KSISVSVAGGASSG-WAL----------------------------------------
--------------GGFGFG------------------SRAFT-----------------
-------GQG-------AGRQTFGP-AC--PPGGI------QEVTVNQSLLTPL----HV
EIDPEIQR--VRT QEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQGQNLG--VTRNNL--EPLFE-AYLGSMRSTLDRLQS
EQGRLDSELRN-VQDLVEDFKNK-YEDEINKRTA---VENEFVVLK--K---DVDAAYMG
RMDLHGKVGTLTQEIDFLQQLYEM-----ELSQVQTHVSDT----NVVLSMDNNRNLDLD
SIIA-EVKAQYELIAQ-RSRAEAEAWYQTK--YEELQVTAGKHGDNLRDTKNEIAELT--
RTIQRLQGE-V--DAAKK------------------------------------------
-----Q-CQ--QLQTAIEEAEH-RGELAL-KDAQKKL----GDLDVALHQAKEELARLLR
DYQELMNIKLALDVEIATYRKLLESEE--------------------------S-RMS-G
ECPSA---V--------SISVTGNSTTVCG------------------------------
-----------------G---------------------GIALGGN---GG--ATKGGFS
TN----------------------------------------VGYST----------V--
KGGPVSG--GTSILRKT--TTVKTSSRRY-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSTKTTIR--SQ--TSHRGFSASSARVPG-----LNRS-GFSSVS-VCRSRGSGGSG
A-------------------------------VC-----------GGAGFGSRSLYGLGC
S-KRISIGGS----GY--GIGGG-------------YGS--LV----GGRFGFGG-----
--------------------------A------GS-----------------AF----GF
S--GG-AGFGV-GYGGAGFP------VC--PPGGI------QEVTINQNLLTPL----NL
QIDPTIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWALLQEQGTK----TVRQNL--EPMFE-QYISNLRRQLDSILG
ERGRLDSELRN-MQDTVEDFKNK-YEDEINRRTT---AENEFVTMK--K---DVDAAYMN
KVELQGRADSLADEINFLRTVFDA-----ELSQMQTHISDT----SVVLSMDNNRSL---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MTSKSTIR--TH--SSSRGYSASSARVPG-----AHRS-GFSSVS-VSRSRGSGGLG
G-------------------------------VC-----------GGAGFGSRSLYGLGA
S-KRISIGGG----SC--AISGG-------------YGG--RV----GGGFGFGGGA-G-
--------------SGFGFG--GG--A------GS-----------------GF----GL
G--GG-AGFGG-GYGGAGFP------VC--PPGGI------QEVTINQNLLTPL----NL
QIDPTIQR--VRTEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWTLLQEQGTK----TVRQNL--EPLFE-QYISNLRRQLDNILG
ERGRLDSELRN-MQDVVEDFKNK-YEDEINKRTA---AENEFVTLK--K---DVDAAYMN
KVELQAKADSLTDEINFLRTIYDA-----ELSQMQTHISDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEEIAQ-RSRAEAESWYQSK--YEELQVTAGRHGDDLRNTKQEIAEIN--
RMIQRLRSE-I--DHVKK------------------------------------------
-----Q-CA--NLQSAIADAEQ-RGEMAI-KDARNKL----EGLEDALQKAKQDMARLLK
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLN-G
EG--VG-QV-------N-ISVVQSSV----------------------------------
------------SSGYGS-------------------------ASGV-------------
---------------------------------------GIGSGLGGGSG----YS----
-----------------------YSSG-----H-SLG--G--------------------
GFSSG---SGRGLG--GGLS--SIGGG-SSSIKYT----TTTSSS---------------
------------------------------------------------------------
------------SSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSL
H-------------F---SSPLFSSRSASFSGR----GAQV-RLSSA----RPGG-----
----------------------------------------------FG-S--SSLYGLG-
------------AS-RPRVAV--RS-----------------------------------
---------------AYG------------------------------------------
----------------G-------P-----VGAGI------REVTINQSLLAPL----RL
DTDPSLQR--VRQ EEREQIKTLNNRFASF------IDK--VR------------------
----FLEQQNK-LLETKWALLQEQKSA-----KSSRL--PDIFE-AQIAGLRGQLEALQV
DGGRLEAELRS-MQDVVEDFKNK-YEDEINRRTA---AENEFVVLK--K---DVDAAYMS
KVELEAKVVALNDEINFLRTLHET-----ELTELQSQISDT----SVVLSMDNSRSLDLD
GIIA-EVKAQYEEMAK-CSRAEAEAWYQTK--FETLQAQAGKHGDDLRNTRNEIAEMN--
RAIQRLQAE-I--DAIKN------------------------------------------
-----Q-RA--KLEAAIAEAEE-RGELAL-KDARAKQ----EELEAALQRAKQDMARQLR
EYQELMSVKLALDIEIATYRKLLEGEE--------------------------S-RLA-G
DGVGA---V--------NICKALLFSL---------------------------------
-PAVVNST-G--G---SGSG----------------GGMGLSFGG-----TMGSNALSFS
SS-----AGPGP------------------------------------------------
--------LKAYSIRTTSTSRRSARN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQSSVS--FR-SGGSRSFSAASAITPS-----VSRT-SFSSV---SRSGG----G
GGGRIS--------------------------LG-------GA-CGAGGYGSRSLYNVGG
S-KRISYSSG----GG--SFRNQ-------------FGAGG---------FGFGGGA-G-
--------------SGFGFG--GGAG-S------------------------GF----GF
G--GGAGFG-G-GYGGAGFP------VC--PPGGI------QEVTVNQNLLTPL----NL
QIDPTIQR--VRT EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLDTKWALLQEQGTK----TIKQNL--DPLFE-QYINNLRRQLDGVLG
ERGRLDSELRN-MQDLVEDYKNK-YEDEINKRTT---AENEFVMLK--K---DVDAAYMN
KVELEARVDALMDEINFMKMFFDA-----ELSQMQTHVSDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEDIAN-RSRTEAESWYQTK--YEELQQTAGRHGDDLRNTKHEISEMN--
RMIQRLRSE-I--DNVKK------------------------------------------
-----Q-CA--NLQNAIAEAEQ-RGELAL-KDARNKL----TELEEALQKAKQDMARLLR
EYQELMNTKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VG-PV-------N-ISVVTNSV----------------------------------
------------SSGYGGGS-S---I----G---VGSGFGGG----LGSG----F-----
-----A----------------------------------------GGL-----GPRFT-
-----------------------RGGG-----GLGLG--SGLSVGG-------------S
GFSAG---SSQG-GMSFGS----GGG-SGSSVKFV----STTS-S---------------
------------------------------------------------------------
-------------SRRSFKS----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTQKTYK--VST--SGPRGFSSLSYTSAPG-----SRI-SSRVV-------------
------------------------------------------------------------
----------------------GG-----------SFRGG------------LGGGS---
--------------G---------------------------------------------
--------------------RAG-------GMGGI------TAVTVNQSLLSPL----NL
EVDPNIQA--VRMQEKEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWNLLQQ-QKT-----SRSNM--DSMFE-SYINNLRRQLESLGQ
EKLKLEAELGN-MQGLVEDFKNK-YEDEINKRTE---MENEFVLIK--K---DVDEAYMN
KVELESRLEGLTDEINFLRQLYEE-----EIRELQAQISDT----SVVLSMDNSRSLDMD
SIIA-EVKAQYEEIAN-RSRAEAESMYQIK--YEELQTKAGKHGDELRRTKTEISEMN--
RNISRLQAE-I--EGLKG------------------------------------------
-----Q-RK--SLENAIADAEQ-RGEMAI-KDANNKL----AELEAALQRAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEES---------------------------RLE-S
---GM---Q--------NVSIHTKTTSG--------------------------------
---------------YSG---------------------GLNT-----------------
---TYG------------------------------GLTSPGLT-SLSSF-------Q--
--------------------------------SS---------FSTGG---------GPF
SR-----------------------TNKAVVVKKI------ETRDGKLVSESSDVLSK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
H-------------F---SSPVFTSRSAAFSGR----GAQV-RLSSA----RPGG-----
----------------------------------------------LG-S--SSLYGLG-
------------AS-RPRVAV--RS-----------------------------------
---------------AYG------------------------------------------
----------------G-------P-----VGAGI------REVTINQSLLAPL----RL
DADPSLQR--VRQ EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-LLETKWTLLQEQKSA-----KSSRL--PDVFE-AQIAGLRGQLEALQV
DGGRLEAELQS-MQDVVEDFKNK-YEDEINRRAA---AENEFVVLK--K---DVDAAYMS
KVELEAKVDALNDEINFLRTLNEM-----ELTELQSQISDT----SVVLSMDNSRSLDLD
SIIA-EVKAQYEEMAK-CSRAEAEAWYQTK--FETLQAQAGKHGDDLRNTRNEISEMN--
RAIQRLQAE-I--DNIKN------------------------------------------
-----Q-RA--KLEAAIAEAEE-RGELAL-KDARAKQ----EELEAALQRTKQDMVRQLR
EYQELMSVKLALDIEIATYRKLLEGEE--------------------------S-RLA-G
D-------G--------VGA-----VN---------------------------------
-ISVVNST-GG-----SSNG----------------GGIGLTLGG-----TMGSNALSFS
SS-----AGPGP------------------------------------------------
--------LKAYSIRTTSTSRRSARN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
H-------------L---SSQVFSSRSSAFPGR----GAQV-RLSSV----RPGT-----
----------------------------------------------FSGSS-SSLYSLG-
------------AS-RPRVAV--RS-----------------------------------
---------------AYG------------------------------------------
----------------G-------P-----VGAGI------REVTINQSLLAPL----QV
DIDPSIQQ--VRQEEREQIKTLNDKFASF------IDK--VR------------------
----FLEQQNK-LLETKWALLQEQKSA-----KSSRL--PSIFE-AHIASLRRQLEGLQA
DGGRLEVELRT-MQGVVEDFKNK-YEDEINRRTA---AENEFVVLK--K---DVDAAYMN
KVELEAKVDALSDEINFFKTFYEM-----ELAELQAQISDT----SVVLSMDNSRSLDLD
SIIA-EVKAQYEEMAN-RSRAEAETMYQIK--FETLQAQAGKHGDDLRNTRNEITEMN--
RAIQRLQAE-I--DNIKN------------------------------------------
-----Q-RA--KLEAAIAEAEE-RGELAV-KDANAKL----AELEAALQRAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEE--------------------------S-RLA-G
DGVGT---V--------NISV---------------------------------------
----VN----------SAGG----------------GGSGVAFGG-----TMGSNALSFS
SG----SGSPGA------------------------------------------------
--------FKSYSIRTSTATHRSIRK----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MNRQVCKK--SF-SGGSQGFSGRSAVVS-G-----SSR-M-SC---VVRSGGA-G--
-----GG-------------------------ACGFR----SGA---GGFGSRSLYNLGG
N-KSISISVAAGGS-RAGGFVGGQS------SCG--FAGGYGSG----FGGSYGGGFGGG
--R--GISSGFG-------------------------------GAGGFGGAGGF------
GGPGVFGGLG--SFDS---PGGFVP-GG--FSGGI------QEVTVNQSLLQPL----NV
EIDPQIGQ--VKA QEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWELLQQQTTG----SGPSSL--EPCFE-SYINFLRKQLDSLLA
ERGNLEGELKS-MQDLVEDFKKK-YEDEINKRTA---AENEFVGLK--K---DVDAAFIN
KVELQAKVDSLTDEVSFLRTLYEM-----ELSQMQSHVSDT----SVVLSMDNNRCLDLD
NIIA-EVRAQYEEIAQ-RSKAEAEALYQTK--LGELQTTAGRHGDDLKNTKSEIMELN--
RMIQRLRAE-I--ENVKK------------------------------------------
-----Q-NG--NLQTAISEAEQ-RGEMAL-KDANAKL----QDLQAALQKAKDDLARLLR
DYQELMSVKLALDVEIATYRKLLEGEE--------------------------C-RMS-G
ECQSA---V--------CISVVSNVTST--------------------------------
---------SGSSGSSRGVFGGVSGS--------GGYRGGGSSSG---------Y-----
--------------GVSGGSSSA-YGAVSG---------GSSSS-YGGVS-SG---ST--
GGRGSSGGYQ--------------------SSSS------GSRLGGAGSMS---MSHSGM
GSSSG--SV-QTSGGSGYKS----GGGGSTSIRFS----QTT------------------
------------------------------------------------------------
----------SSS-QHNSTK----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTQKSYK--VST--SGPRAFSSRSYTSGPG-----VRV-SSSSF-------------
-------------------------------------------------------SRVGS
G---------------------S------------SFRGS------------M-------
--------------GL---G----------------------------------------
---------------GI---GGA-------SGGGI------TAVTVNQSLLNPL----KL
EVDPNIQA--VRT QEKEQIKSLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWSFLQQ-QKT-----ARSNM--DNMFE-SYINNLRRQLDSLGQ
EKLKLEAELGN-MQGLVEDFKNK-YEDEINKRTE---MENEFVLIK--K---DVDEAYMN
KVELESRLEGLTDEINFLRQIYEE-----EIREMQSQISDT----SVVLSMDNSRSLDMD
GIIA-EVKAQYEEMAN-RSRADAERMYQIK--YEELQTMAGKHGDDLRRTKTEISDMN--
RNISRQQAE-I--ETLKS------------------------------------------
-----Q-KA--SLEAAIADAEQ-RGEMAI-KDANAKL----AELEAALKRAKQDMAQQLR
EYQELMNVKLALDIEIATYRKLLEGEES---------------------------RLE-S
---GM---Q--------NMSIHTKTTSG--------------------------------
---------------YSG---------------------GLSS-----------------
---AYG------------------------------GLTSPGFNYNMSSF-------Q--
--------------------------------PS---------FSPMG---------GSS
TFTRT---------------------TKAVVVKKI------ETRDGKLVSESSDVLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
----------------------------------------------------------MR
S-SVSRQTYST--------KGGFSSNSASGG---GGSRMRT-SYSSVT-MSRSSGS--G-
--------------------------G---GV---------RSCPGSGGFGSRSLYNLGG
--KNISVSVAGGASSG-RAL----------------------------------------
--------------GAFG--------------------TGAYM-----------------
-------GPG-------AGRQTFGP-VC--PPGGI------QEVTVNQSLLTPL----NV
EIDPEIQR--VRT QEHAQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQSQNTG--VTK-NL--EPLFE-TYLSNLRRQLDAKQS
EHGRLDMELRS-VQDNLEDFKNK-YEDEINKRTA---LENEFVLLK--K---DVDAAYMG
RMDLHGKVDTLTQEIDFLQHLFEM-----ELSQVQTNVSDT----NVVLSMDNNRSLDLD
SIIA-EVKAQYELIAQ-KSRAEAESWYQTK--YEELQVTAGKHGDSLRDTKNEIAELT--
RTIQRLQGE-L--DATKK------------------------------------------
-----Q-CQ--QLQTAIAEAEQ-RGEMAL-KDAKKKL----GDLDTALHQAKEDLARLLR
DYQSLMNVKLALDVEIATYRKLLESEE--------------------------S-RWQ-A
PCSSA--------------AVTGNSTSVCA------------------------------
-----------------GG--------------AAGFGSGLSLGGA---GG--ANKGGFS
AN----------------------------------------VSYGT----------A--
KGGQVSG--GTSILRKT--TTVKTSSRRY-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
-------------------------------MN------QRSS---ITIKSGGTQNF---
-------------------SASSASLLPGCRPN----FSSF-SVSQN----R--------
---------------------------------------KSIGGGLGGGFGTRSLHGFGG
S-KRISISGGYHSS-R-GSFGGSSC-----------------------------------
---------------GLGMG-------GMGYRAGG-------------------------
------------AFGGYGFGGGMVH-----GGRGI------QEVTINQSLLTPL----HL
EIDPSLQH--VRK EEKEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWSLLQEHKTT-----RA-NL--EPMFE-TYISNLRRQLDCLGG
ERGRLEMELKS-MQDVVEDFKNK-YEEEINRRTA---AENEFVVLK--K---DVDAAYMN
KVELEAKVDALMDEINFLRAFYEA-----ELAQLQAQISET----SVVLSMDNNRKLDLD
SIIA-EVKAQYEDIAN-RSRAEAETWYQTK--YEELQRSASQHGDDLRTTRMEISELN--
RAMQRLRSE-I--DSLKK------------------------------------------
-----Q-CA--TLQAAIADAEQ-RGELAL-KDAKNKL----AELEEALQKAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEE--------------------------H-RLT-G
EGVGS---V--------NISVVSSSGGTGYSGGS--------------------------
-G----LS-MGGG-GY--------------------GGGF-SGGLCYSGSG----SSGFS
STSGR-SLSGTS------------------------------------------------
--------SSMRIISRTSSTKKSYRS----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
H-------------F---SSPVFTSRSAAFSAR----GAQV-RLSSA----RPGG-----
----------------------------------------------LG-S--SSLYGLG-
------------AS-RPRVAV--RS-----------------------------------
---------------AYG------------------------------------------
----------------G-------P-----VGAGI------REVTINQSLLAPL----RL
DADPSLQR--VRQ EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-LLETKWMLLQEQKSA-----KSSRL--PDVFE-AQIAGLRGQLEALQV
DGGRLEAELRS-MQDVVEDFKNK-YEDEINCRAA---AENEFVVLK--K---DVDAAYMS
KVELEAKVDALNDEINFLRTLSEM-----ELTELQSQISDT----SVVLSMDNSRSLDLD
SIIA-EVKVQYEEMAK-CSRAEAEAWYQAK--FETLQAQAGKHGDDLRNTRNEISEMN--
RAIQRLQAE-I--DNIKN------------------------------------------
-----Q-RA--KLEAAIAEAEE-RGELAL-KDARAKQ----EELEAALQRTKQDMVRQLR
EYQELMRVKLALDIEIATYHKLLEGEE--------------------------S-RLA-G
D-------G--------VGA-----VN---------------------------------
-ISVVNST-GG-----SSNG----------------GGIGLTLRE-----TMGSNALSFS
SS-----AGPGP------------------------------------------------
--------LKAYSIRTTSTSRRSARN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
MA--STSTTIR--SH-SSSRRGFSAGSARLPG-----VSRS-GFSSVS-VSRSRGSGGLG
G-------------------------------AC-----------GGAGFGSRSLYGLGG
S-KRISIGGG----SC--AIGGG-------------YGS--RA----GGSYGFGG-A-G-
--------------SGFGFG--GG--A------GI-----------------GF----GL
G--GG-AGLAG-GFGGPGFP------VC--PPGGI------QEVTVNQSLLTPL----NL
QIDPAIQR--VRA EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWTLLQEQGTK----TVRQNL--EPLFE-QYINNLRRQLDSIVG
ERGRLDSELRG-MQDLVEDFKNK-YEDEINKRTA---AENEFVTLK--K---DVDAAYMN
KVELQAKADTLTDEINFLRALYEA-----ELSQMQTHISDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEEIAQ-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEIAEIN--
RMIQRLRSE-I--DHVKK------------------------------------------
-----Q-CA--SLQAAIADAEQ-RGEMAL-KDAKNKL----EGLEDALQKAKQDLARLLK
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLN-G
EG--VG-QV-------N-ISVVQSTV----------------------------------
------------SSGYGGASG-------------------------V-------------
---------------------------------------GSGLGLGGGSS----YS----
-----------------------YGSG--------------LGVG--------------G
GFSSS---SGRAIG--GGLS--SVGGG-SSTIKYT----TTSS-----------------
------------------------------------------------------------
------------SSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSLQSSIT--FQAG-SRRGFSTTSATTPA-----AQHS-HFSSIS-VTHSSG--GNG
GLGRIS--------------------------SA------------GAGFGSRSLYNLGG
T-KRTSVGGC-SSS-----FRSS-------------FGS--RA----GSKFGFAS---S-
--------------SGFGYG--GGVGGGF-------------------------------
--------------GSPGFP------V---PSDGI------QVVTVTQSLLSPL----YL
QIDPTIQR--VQKEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQEQGSR----TVRQNL--EPLFD-AYTSELRRQVDRITT
ERGRLEAELRN-MQDIVEDFKVR-YEDEINKRTA---AENEFVALK--K---DVDGAYMN
KVELEARVNSLTDEINFFRMLYEA-----ELSQMQTQVSDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEDIAN-RSRAEAESWYQTK--YKELQVTAGRHDNDLRNTKHEISEVN--
RVIQRLRAE-I--DSVKK------------------------------------------
-----Q-CA--SLQTAIADAEQ-RGELAL-KDALAKL----VDLEEALQKAKQDMARLLR
EYQELMNVKLALDVESATYRKLLEGKE--------------------------S-RLS-G
EG--VS-PVNIS--------VVTNTV----------------------------------
------------PRGYGSGSGSGIG-----------------------------------
---------------------------------------GGSLGLSGGSS----YSFTT-
-----------------------SG-------GHSVG--A--GLGG-------------S
AFSAS---SSRGLGG------------SGPSVKFV----STTP-----------------
------------------------------------------------------------
------------SSRKNYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
----------------------------------------------------------MR
S-SLSRQTFST--------KGGFSSNSASGG---GGSRMRT-SYSSVT-MSRGS--G---
--------------------------G---GV---------RSGSNSGGFGSRSLYNLGG
--KNISVSVACGASSG-RAL----------------------------------------
--------------GGFG--------------------SGAYV-----------------
-------GLG-------AGRQTFGP-VC--PPGGI------QEVTVNQSLLTPL----NV
EIDPEIQR--VRT QEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQSQNTG--VAR-SL--EPFFE-NYLSTLRRQLDTKQS
ERGRLDMELRN-VQDNLEDFKNK-YEDEINKRTA---LENEFVLLK--K---DVDAAYMG
RMDLHGKVDSLTQEIDFLQQLFEM-----ELSQVQTNVSDT----NVILSMDNNRSLDLD
SIIA-EVKAQYELIAQ-KSRAEAESWYQTK--YEELQVTAGKHGDSLRDTKNEIAELT--
RTIQRLQGE-V--DAAKK------------------------------------------
-----Q-CQ--QLQTAIAEAEQ-NGEMAL-KDAKKKL----GDLDTALHQAKEDLARMLH
EYQDLVSVKLALDMEIATYRKLLESEE--------------------------S-RMS-G
DCPSA---I--------SISVTGNSTSVCA------------------------------
-----------------GG--------------SAGFGNGLSLGGA---GG--ASKGGFG
TS----------------------------------------VSYGA----------A--
KGGQVSG--GTSILRKT--TTVKTSSRRY-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MSRQACKK--SF-SRGSWGFSGHSAVVSG-------SR-K-SC---VARSGAN-S--
-----GG-------------------------TYGFW----SG---AGGFGSHSLYSLGG
S-KSISISMTAGGS-RTGGFSAGHG------SCGSGFRGSYGGGFGGGRG----------
------MGG-------------------------------------------------GF
GGAG--------SFGR---TGNFGP-SG--CPGGI------QEVTINQSLLQPL----NV
EIDPQVGQ--VKA QEHEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWELLQQQTASSS--SGSQNL--EPFFE-SYISCLRKQLDSLLG
EKGNLEGELKS-MQELVEDFQKK-YEDEVNKRTA---AENEFVGVK--K---DVDVAYMN
KVELQAKVDSLTDEVNFLRTLYDM-----ELCQMQSHVSDM----SVVLSMDNNRSLDLD
GIIA-EVKAQYEDITQ-RSKAEAEALYQAK--FGELQTTAGRHGDDLTNTKSEILELN--
RIVQRLRAE-I--ENVKK------------------------------------------
-----Q-NA--NLQTSIAEAEQ-RGDMAL-KDANAKL----QDLQAALQKAKDDLARLLR
DYQELMNVKLALDMEIATYRKLLEGEE--------------------------C-RMS-G
ECQSA---V--------SISVISNVTS---------------------------------
--------TSSS----SGSFRGVSGS----SS--SGSRGGS-------------------
----------------SSGSRG--------------------------GS--SSYGGD--
SR---------G------------SSGGYPSGSS------ESRLGGGGSI--SV-SQRGT
GFSSG--DT-QTSGGSRFKS----GSGGSTNVHFS----RII------------------
------------------------------------------------------------
----------SSG-QQQSK-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MNRQVCKK--SF-SSGSQGFSGRSAVVS-G-----SSR-M-SC---VARSGGA-S--
-----GG-------------------------ACGFR----SGG---GGFGSHSLYNLGG
N-KSICMSVAAGGS-RAGGFGGGRS------LCG----GGYGGG----YGAGFGGGFGGG
--R--GVGGGFG-------------------------------GAGGFGGAGGFG-----
-GPGGFGGPG--GFGG---PGGFGP-GG--FPGGI------QEVTVNQSLLQPL----NV
EIDPQIGQ--VKAQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQQQGSGSG--SGPNNL--EPLFE-SYISYLRRQLDLLLG
ERGNLDGELRN-VQDLVEDFKKK-YEDEINKRTA---AENEFVGLK--K---DVDAAYMN
KVNLQAQVDSLSDELNFLKTLYET-----ELSQMQRHISDT----SVVLSMDNNRCLDLD
SIIA-EVKAQYEDIAQ-RSKAEAEGLYQTK--LGELQTTAGRHGDDLRNTKSEIMELN--
RMIQRLRAE-I--ENVKK------------------------------------------
-----Q-NA--NLQAAIGEAEQ-RGELAL-KDANAKL----QDLQDALQKAKDDLARLLR
DYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RMS-G
ECQSA---V--------SISVVSSVSST--------------------------------
---------SSSRGGYG----GLGGS----GS--GGYGGLSGGG----------------
---------------SSRGRSGG-YGAASG---------GSGH-----------------
---------------------------------------------------------GGV
TGSSG--SY-QSSGGSGSRL----GGGGSSSVSQS----SSS------------------
------------------------------------------------------------
----------SVQ-TSGGSSGYKSG-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MISKQHCVR-----G-GSRGFSCSAVGRGGR----K-----AASAS---LSGGG----
-----------------------------------------GRCS-SGGFGSRSLYNLRG
N-KSICSSVAGARQ-GA-GFGGAGG-----------------------------------
------------------------------------FGAGGIG-----------------
---GGFGG----SFS--GRGGPGFP-VC--PPGGI------QEVTINQSLLTPL----HV
EIDPEIQK--VRTEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQQQTTTT----SSKNL--EPFFE-NYLIVLRKQLDGLAN
DKGRLQSELKV-MQDSVEDFKTK-YEDEINKRTT---AENEFVVLK--K---DVDAAYMN
KVELEAKVDALNDEINFLRALYEA-----ELAQMQTHVSDT----SVVLSMDNNRCLDLD
SIIA-EVKAQYEDIAQ-KSKTEAEALYQIK--VQELQISVDQHGDSLKNTKMEIAELN--
RMIQRLRAE-I--ENVKK------------------------------------------
-----Q-CE--ALQTSVADAEQ-RGELAL-KDANAKL----QDLKAALQQAKEELARILR
DYQELMNVKLALDIEIATYRKLLEGEE--------------------------C-RMS-G
ECQSA---V--------SISVVGGAASAGG------------------------------
---------------MGG-G----------------------------------------
----CGL------------------------GGGFGSG--AGSGFGF--G-GG-------
----VCGSSSSKIICTPTLNKRYR------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------TST
R--VTQKFYK--VS--TSGRSYSNNSLPEEWPG-----AHM-SSLSF-------------
-------------------------------------------------------SRVGS
-----------------------S-----------SFYGA------------RGR-----
------------------------------------------------------------
--------------------------------GGI------TAVTVNQSLLSPL----NI
EVDPNIQD--ICTQEKEQINTLNNRFVSF------INR--VQ------------------
----FLEQQNK-MLETKWSLLLQ-RKT-----AWSNM--DNILE-SYINNLRRQLETLGQ
ETLKLEAELGN-TQGLVKDFKNK-YEDEINKRTE---TENEFVLIK--K---DVDEAYMN
KVELESHLKGLTHEIKFLRQLYEE-----EIRKLQSQIWDT----SVVLSMDNSRSLNMD
STIT-EVKAQSDKIAK-HSRAGAESMYQIH--YEGLQTLAGKHRDDLQCTKTENSKMN--
WNISQLETE-T--EGLQC------------------------------------------
-----Q-RA--PLEVAITVAEQ-RRELAV-KDARAKL----SELVVALQRAKQDLQHQLR
KYQELMNIKLALDIENAVCWKLLEGEES---------------------------WLE-S
---GL---Q--------NMSIHWKTTIG--------------------------------
---------------YGD---------------------ALIS-----------------
---AYG------------------------------DLTTPSLSS------------L--
--------------------------------GS--------SFGSGW---------GSS
SFSRT-------------------SSTRAMVVK-V------ETRD---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSM
R--VTQKTYK--VSI--SGPRGFSSLSYSSGQG-----SRI-SSSSF-------------
-------------------------------------------------------SRMGS
S----------------------S-----------SFRGG------------LG------
-------------------L----------------------------------------
---------------GGY-GRAA-------GVGGI------TAVQVNQSLLNPL----NL
EVDPNIQA--VCI QEKEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQQ-QKT-----SRSNM--DNMFE-SYINNLRWQLDTLGQ
EKLKLEAEIGN-MQGLVEDFKNK-YEDEINKPTE---MENEFVLIK--K---DVDEVYMN
KVELESYLEGLTDEINFLRQLYEE-----EIRELQSQISDT----SVVLSMDNSRSLDLD
GIIA-EVKAQYEEIAN-RSRAEAESIYQIK--YEELQTLAGKHGDDLRRTKSEISEMN--
GSISHLQAE-I--KALKG------------------------------------------
-----Q-RA--SLEAATADAEQ-RGELAI-KDANTKL----AQLESALQKAKQDMARQLR
EYQELMNVKLALDIEIATYLKLLEGKEN---------------------------RLE-A
---GM---Q--------NMSIHMKTTSG--------------------------------
---------------YSG---------------------MS-------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------AVVVKKI------ETCDGKLVSETSDVLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSR
QSSVS---------FRSGGSRSFSAASAITPS-----VSRT-SFTSVSRS--GGGGGG--
-MGRVS-----------------------------L----GGACG-AGGYGSRSLYNVGG
S-KRISMSTSGSSF-V-NRFGA--R-----------------------------------
--------------GGYGFG----GGVGIGFVRRSGW-------------------GIGF
VG--------ATGCRR-SSAGPXXX--X--XXXX---------XXXXXXXXXXXXXXXXX
XXXXXXXX--XXXXXXXXXXXXXXXXXXX------XXX--VR------------------
----FLEQQNK-VLDTKWTLLQEQGTKT----VRQNL--EPLFE-QYINNLRRQLDSVLG
ERGRLDSELRN-MQDLVEDFKNK-YEDEINKRTT---AENEFVMLK--K---DVDAAYMS
KVELEAKVDALMDEINFMKMFFEA-----ELSQIQTHVSDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEDIAN-RSRTEAESWYQTK--XXXXXXXXXXXXXXXXXXXXXXXXXX--
XXXXXXXXX-X--XXXXX------------------------------------------
-----X-CA--NLQNAIADAEQ-RGELAI-KDARNKL----AELEDALQKAKQDMARLLR
EYQELMNTKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG-VGP--V--------NISVVTN-S---V------------------------------
------------SSGYGG----G-SS----SFGG-------------------GFG----
---SG---------------------------------------LGG-------------
---GGG-----------------------------------------------------G
GYYSS--SS-RGMGLGGGLSVGGSGFSASSGRG---------------------------
------------------------------------------------------------
----------MGM-GFGSGGGSSSSVKFVSTTSSSRKSFK-------S------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MIARQQGVR-----G-GSRGFSCGSAVVGGG----KRA--AFSSVS---VSGGA----
-----------------------------------------GRCS-SGGFGSRSLYNLGG
N-KSISMSVAGSRQ-GT-CFGGAGG-----------FGA---------------------
---------------------------------------GGFG-----------------
---GGFGG----SFG--GRGGSGFP-VC--PAGGI------QEVTINQSLLTPL----HV
EIDPEIQK--VRT EEREQIKILNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQQQTTTT----SSKNL--EPFFE-TYLSALRQQLDAFAN
DKGRLQSELKT-MQDSVEDFKTK-YEEEINKRTA---AENDFVVLK--K---DVDAAYMT
KVELEAKVDGLNDEINFLKVLYDA-----ELSQMQTHVSDT----SVVLSMDNNRNLDLD
SIIA-EVRAQYEEIAQ-KSKAEAEGLYQIK--VQQLQISVDQHGDNLKNTKIEIAELN--
RMIQRLRAE-I--ENVKK------------------------------------------
-----Q-CQ--TLQTSVADAEQ-RGENAL-KDAYSKR----TELEAALQRAKEELARILR
DYQELMSVKLALDVEIATYRKLLEGEE--------------------------C-RMS-G
ECQSA---V--------SISMVGGGSSAGG------------------------------
---------------IGR-G---LGS-----------------------------SS---
---GFGL------------------------GGGFGSG--SGSGFGF--G-GG-------
----VSGSSSSKIISTTSLTKKSYR-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSR
HFS-SRSGYRS--G------GGFSSGSAGVVS-----LQRR-GTSCS--VRRSGGGG---
G--RFS------------------------GGGCGGGG-------AGGGFGSRSLVNLGG
S-KSISISVARGGG-R-SGFGGG---------Y-G---SGGFGS------GGFGS-----
--------------GGF----------------GGGFGSGGGFGG--GS---------F-
G---------G-GFGGGSFGGGFGP-VC--PPGGI------QQVTINQSLLQPL----HV
EIDPEIQK--VKSQEREQIKSLNNQFASF------IDK--VR------------------
----FLEQQNQ-VLQTKWELLQQINTST----RTHDL--TPYFE-SYINSLRKRMDQLKS
DQSRMDSELKT-MQDLVEEYRNK-YEEEINKRTN---AENEFVTIK--K---DVDAAYMA
KVELQAKVDNLRQEIDFFTALYQM-----ELSQMQTHISDT----NVILSMDNNRSLDLD
SIIA-EVKNQYEEIAQ-RSKVEAEALYQTK--YEELQITAGQHGDNLKTSKMEISELN--
RLIQRLRAE-I--NSVKK------------------------------------------
-----Q-IS--GLQQSISDAEQ-RGENAL-KDAQGKL----NELEDALHQAKEDMARLLR
DYQELMNTKLALDVEIATYRALLEGEE--------------------------S-RMS-G
ECAP-N--V--------SVSVSTSHTSISG------------------------------
------------GGGRGG---GGSYG----SGGG--YGGG-----------GGSYGG---
---GY--------------------------------------GSGGGSG-GGSYGGS--
-------YGGG-----------GGSSGGH-RGGS------GGGGGSSGGR-GSSGGG---
--GGG--S----SGGRGSSSGGTKTSGGSSSVKFI----STS------------------
------------------------------------------------------------
----------YSP-GTR-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSM
R-V-TQKTYK--VSI--SGPRGFSSLSYSSGPS-----SRI-SSSSF-------------
-------------------------------------------------------SRMGS
S----------------------S-----------SFRGG------------LGL-----
------------------------------------------------------------
---------------GGY-GRAA-------GVGGI------TAVQVNQSLLNPL----NL
EVDPNIQA--VRIQEKEQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQQ-QKT-----SRSNM--DNMFE-SYINNLRWQLDTLGQ
EKLKLEAELV--------------------------------------------PIVYMN
KVELESYLEGLTDEINFLRQLYEE-----EIRELQSQISDT----SVVLSMDNSRSLDLD
GIIISDTSAQYEEIAN-RSRAEAESIYQIK--YEELQTLAGKHGDDLRRTKSEISEMN--
GSISHLQAE-I--KALKG------------------------------------------
-----Q-RA--SLEAATADAEQ-RGELAI-KDANTKL----AQLESALQKAKQDMARQLR
EYQELMNVKLALDIEIATYLKLLEGKEN---------------------------RLE-A
---GM---Q--------NMSIHMKTTSG--------------------------------
---------------YSG---------------------VMSS-----------------
---PYR------------------------------VLPTPGFGSLQS------------
---------------------------------P--------------------------
GF--T-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MIARQQCVR-----G-GPRGFSCGSAIVGSG----KRG--AFSSVS---VSGGA----
-----------------------------------------GRCS-SGGFGSRSLYNLGG
N-KSISMSVAGSRQ-GA-CFGGAGG-----------FGT---------------------
---------------------------------------GGFG-----------------
---GGFGG----SFS--GKGGPGFP-VC--PAGGI------QEVTINQSLLTPL----HV
EIDPEIQK--VRT EEREQIKLLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWKLLQQQTTST----SSKNL--EPLFE-TYLSVLRKQLDTLVN
DKGRLQSELKT-MQDSVEDFKTK-YEEEINKRTA---AENDFVVLK--K---DVDAAYMN
KVELEAKVDSLNDEINFLKVLYDA-----ELSQMQTHVSDM----SVVLSMDNNRNLDLD
SIIA-EVRAQYEEIAQ-RSKAEAEALYQTK--VQQLQISVDQHGDNLKNTKSEIAELN--
RMIQRLRAE-I--ENIKK------------------------------------------
-----Q-CQ--TLQASVADAEQ-RGENAL-KDAHSKR----IELETALQQAKEELARMLR
EYQELMSVKLALDIEIATYRKLLEGEE--------------------------C-RMS-G
ECQSA---V--------SISVVGGSTSTGG------------------------------
---------------ISG-G---LGS-----------------------------GS---
---GFGL------------------------SSGFGSG--SGSGFGF--G-GS-------
----VSGSSSSKIISTTTLNKRR-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MIARQQCVR-----G-GPRGFSCGSAIVGGV----KRR--ACSSAS---VSGGA----
-----------------------------------------GRCS-SGGFGSRSLYNLGG
N-KSISMSVAGSRQ-GA-CFGGAGG-----------FGSGG-------------------
-----------------------------------------FG-----------------
---GGFGG----SFS--GKGGPGFS-VC--PAGGI------QEVIINQSLLTPL----HV
EIDPEIQK--VRT EEREQIKILNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQQQTNTT----SSKNL--EPLFE-TYLSVLRKQLDTLVS
DKGCLQSELKT-MQDSVEDFKAK-YEEEIHKRTA---AENDFVVLK--K---DVDAAYMN
KVELEAKVDSLNDEINFLKVLYDA-----ELSQMQTHVSDT----SVVLSMDNNRNLDLD
SIIA-EVRAQYEEIAQ-RSKAEAEALYQTK--VQQLQVSVDQHGDNLKNTRSEIAELN--
RVIQRLRAE-I--ENIKK------------------------------------------
-----Q-CQ--TLQASVADAEQ-RGENAL-KDAHSKR----IELEAALQQAKEELARMLR
EYQELMSVKLALDVEIATYRKLLESEE--------------------------Y-RMS-G
ECQSA---V--------SISVVSGSTSTGG------------------------------
---------------ISG-G---FGS-----------------------------GS---
---GFGL------------------------SSGFGSG--SGSGFGF--G-GS-------
----VSGSSSGKIISTTTLNKRSHR-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--M-SRQSTIT--FHSG-SHRGFSTASATTPA-----AGRS-RFSSVS-VARSTG--GSG
GLGRIS--------------------------GA------------GAGFGSRSLYNLGG
S-KRVSIGGG-SRG-----FRNG-------------FGG--RA----GTGFGI-----S-
--------------NGFGYG--SGVGGSF-------------------------------
--------------GGPGFP------VC--PSGGI------QEVTINQSLLTPL----NL
QIDPSIQR--VRK EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQEQGSR----TVKQNL--EPLFD-TYINDLRRQLDGITT
ERGRQEAELRN-MQEVVEDFKVR-YEDEINKRTA---AENEFVTLK--K---DVDAAYMN
KAELEAKVDALTDQINFHRVVFEA-----ELSQMQTQVSDT----SVVLSMDNNRNLDLD
SIIA-EVKAQYEDIAN-RSRAEAESWYQTK--YEELQVTAGRHGDDLRNTKQEISEVN--
RMIQRLRAE-I--DSVKK------------------------------------------
-----Q-CS--SLQTAIADAEQ-RGELAL-KDARAKL----VDLEEALQKAKQDMARLLR
EYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RLS-G
EG--VS-PVNIS--------VVTSTI----------------------------------
------------SSGYGSGS--GIA-----------------------------------
---------------------------------------SGSLGLGGGSG----YSFTT-
-----------------------SG-------GHSLG--T--GLGG-------------S
GFTAS---SSRGPGG------------SGSSVKFI----STTS-----------------
------------------------------------------------------------
------------SSRKNYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MNRQICKK--SF-SGGSQGFSGRSAVVS-G-----STR-M-SC---VARSGGA-S--
-----GG-------------------------ACGFR----SGA---GGFGSRSLYNLGG
N-KSISISVAGGSS-RAGGFGGGRS------SCG--FG-----G----YGGGFGGGFGGG
--R--GVGGSFG-------------------------------GVGGFGGAGGFGGAGGF
GGSGGFGGPG--GFGG---P------GG--FPGGI------QEVTVNQSLLQPL----NV
EIDPQIGQ--VKA QEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWELLQQQTTGSG--SGPSSL--EPFFE-SYISFLSKQLDSLLG
ERGNLEGELKN-MQDLVEDFKKK-YEDEINKRTT---AENEFVGLK--K---DVDAAYMN
KVELQAKVDSLMDEVNFLRTLYDM-----ELSQMQSHVSDT----SVILSMDNNRCLDLD
SIIA-EVCAQYEDIAQ-RSKAEAEALYQTK--LGELQTTAGRHGDDLRNTKSEIAELN--
RMIQRLRAE-I--ESVKK------------------------------------------
-----Q-NA--NLQTAIAEAEQ-RGEMAL-KDANAKL----QDLQAALQKAKDDLARLLR
DYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RMS-G
ECQSA---V--------SISVVSNVTST--------------------------------
---------SSSAGGSRGGFGGVSGS----SS--GGYRGGSSSSR---------------
---------------------GS-SGGVSG---------GSSSGYGGVSG-GS---SG--
GR-GSSGGYQS-------------GSSGYQSGSS------GSRLGGAGSSS---VSQSGM
GSSSG--SI-QTSG--GYKS----GSGGSTSVRFS----QTT------------------
------------------------------------------------------------
----------SSS-QYSSK-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------MSIHFSSRSTAFPGR----SAQG-RLSSG----RPGG-----
----------------------------------------------FGS---SSLYGLG-
------------AS-RPRVAV--RS-----------------------------------
---------------SYA------------------------------------------
----------------G-------P-----EGAGI------REVTVNQNLLAPL----RV
DIDPTIQQ--VRQ EEREQIKALNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWALLQQQKSA-----KSSQL--PGIFE-AQISGLRRQLEALQL
DGGRLEVELRN-MQDVVEDFKNK-YEEEINRRAA---AENEFVVLK--K---DVDAAYIN
KVELEAKVDSLNDEINFLKTLNET-----ELAELQSQISDT----SVVLSMDNNRSLDLE
SIIA-EVKAQYEEMAN-HSRAEAEVWYQTK--FETLQAQAGKHGDDLRNTRNEIAEMN--
RAIQRLQAE-I--DAMKN------------------------------------------
-----Q-RA--KLEASIAEAEE-RGEMAL-KDARAKQ----EELEAALQQAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEE--------------------------S-RMS-G
DGVGP---V--------NISM---------------------------------------
----VNA----------AGV----------------SGGRLVLGG-----TMGSNALSFS
SS-----GGPGA------------------------------------------------
--------LKAFSIRTTSTTHRNPLN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------M--
----SRQASKT--S--GGGSQGFSGRSAVVSG------SSR-M-SS---VTRSGAA-G--
-----GG-------------------------ACGFR----SG---AGGFGSRSLYNLGG
N-NSISFRVAAGGS-RAGGFVGGQS------S--CGFAGGYGGGFGGGYGGGFGGGFGGV
--R--GMGGGFGGAGGFG--------GAGGFGGA-----GGFGGAGGFGGPGGFGGAGGF
GGPGSFGSPG--GF-G---P------GG--FPGGI------QEVTVNQSLLQPL----NV
EIDPQIGQ--VKAQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWNLLQQQSTSSI--SGTDNL--EPLFE-NHINYLRSYLDNILG
ERGRLDSEMRN-MQDLVEDFKKK-YEDEMNKRTA---AENEFVTLK--K---DVDGAYMK
KVELQAKVDALIDEINFLRTLYDA-----ELSQMQSHISDT----SVVLSMDNNRSLDLD
SIIA-EVRAQYEDIAQ-RSKAEAEALYQTK--LGELQTTAGRHGDDLRNTKSDIIELN--
RMIQRLRAE-I--ESIKK------------------------------------------
-----Q-NA--NLQTAIVEAEQ-RGEMAL-KDANAKL----QELQAALQQAKDDLARLLR
DYQELMNVKLALEVEIATYPKLLEGEE--------------------------Y-RMS-G
ECPSA---V--------SISVVSSST----------------------------------
--------TSASAGGYAGGYGG-------------GVGGGLGGGL---------------
--------------------GA----GGG-----------SSSGFGRGGG--GGIGGG--
IGGGIGGGF--------------GGGS--------------------SGG--F-SGGSGF
GSSSG--AR-YGVSGGGFSS----ASNRGGSIKFS----QSS------------------
------------------------------------------------------------
----------QSS-QRYSR-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------MSIHFSSRSTAFPGR----GAQM-RLSSG----RTGS-----
----------------------------------------------FGS---SSLYGLG-
------------TS-RPRVAV--RS-----------------------------------
---------------AYG------------------------------------------
----------------S-------P-----VGAGI------REITINQNLLAPL----RV
DIDPTIQQ--VRQ EEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWALLQEQKSA-----KSSQL--PRIFE-TQIAGLRQQLEALQL
DGGRLEAELRG-VQDVVEEFKNK-YEEEINRRTA---AENEFVLLK--K---DVDAAYMN
KVELEAKVDSLNDEISFLKTLNET-----ELAELQSQISDT----SVVLSMDNSRSLDLD
GIIA-EVKAQYDEMAN-HSRAEAEAWYQTK--FETLQAQAGKHGDDLRNTRNEIAEMN--
RTIQRLQAE-I--DTVKN------------------------------------------
-----Q-RA--KLEASIAEAEE-RGELAL-KDAHAKQ----EELEAALQQAKQDMARQLR
EYQELMNVKLALDIEIATYRKLLEGEE--------------------------S-RLS-G
DGTGP---V--------NISV---------------------------------------
----VNS----------TGG----------------SGSRLLFGG-----TMGSNALSFT
SS-----GGPGA------------------------------------------------
--------LKAYNIRTTSTTRRGPHN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------L-----WGVSCSEEQLLAPSLISVWFGPPSSTPASIMSI
R--VTQKSYK--TST--SGPRAFSSRSYTSGPS-----ARI-SSSSF-------------
-------------------------------------------------------SRVGS
S----------------------S-----------GFRSG------------LGMGL---
--------------G---------------------------------------------
------------------GGYA------------G------AAVTVNQSLLNPL----NL
EVDPNIQA--VRN QEKEEIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-MLETKWSLLQQ-QKT-----ARSNM--DGMFE-NYISNLRRQLDTLGQ
EKLKLEAELGN-MQGLVEDFKNK-YEDEINKRTE---MENEFVLIK--K---DVDEAYMN
KVELESRLEGLTDEINFLRQLHEE-----EIRELQSQITDT----SVVLSMVNSRSLDMD
SIIA-EVRAQYEDIAN-RSRAEAESMYQTK--YEELEVLAGKHGDDLRRTKTEISDMN--
RNISRLQAE-I--EGLKG------------------------------------------
-----Q-RA--SLEAAIADAEQ-RGNLAV-KHAKDKV----DELNAALQRAKQDMAWQLR
EYQELMKVKLALDIEIATYRKLLEGEEQ---------------------------RLE-S
---GM---Q--------NMSIHTKTTSG--------------------------------
---------------YSG---------------------GLSS-----------------
---AYG------------------------------GLTSPGLSYGLS--------SF--
--------------------------------PP--------SFGSGG---------SSG
SFSRT-------------------GSSRAVVVKKI------ETRDGKLVSESSDVLPK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------M--
----NRQVRKT--S--GGGSQGFSGRSAVVS------GSSR-M-SC---VARSGGA-G--
-----GG-------------------------AYGFR----SG---AGGFGSRSLYNLGG
N-KSISISVAG-GS-RAGGFGGGRS------SCVSGFGSGYGGGYGGGFGG---------
-GR--GMGGGFGA---------------GGFGGA-----GGFGGAGGFGGAGGFGGAGGF
GGPGGFGGPG--GF-G---PGGFGP-GG--FPGGI------QEVTVNQSLLQPL----NV
EIDPQIGQ--VKAQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWSLLQQQGTHPI--TGTNNL--EPLFE-NYINSLRSHLDSILG
ERGRLDSELRN-MQDLVEDFKKK-YEDEINKRTA---AENEFVTLK--K---DVDAAYMN
KVELQAKVDALTDEINFLTTLYDM-----ELSQMQSHVSDT----SVVLSMDNNRSLDLD
SIIA-EVKAQYEEIAQ-RSKAEAEALYQTK--LGELQTTAGRHGDDLKSTKSEISELN--
RMIQRLRAE-I--ENVKK------------------------------------------
-----Q-IA--KLQSAVAEAEQ-RGELAL-KDANAKL----QELQAALQQAKDDLARLLR
DYQELMNVKLALDVEIATYRKLLEGEE--------------------------C-RW---
-A---------------SYSVVSSSS----------------------------------
-------TTSASAGGFGGGYGG-------------GVGVGGG------------------
----------------------------------------VRSGFGG--G--SGFGGG--
SGFSGGSGFGGG------SGFGGGS-SGFGG--------------GS-SG--FGGGSSGF
GSGSG--GR-SAVSGGGVSSS---SSSRGGSVRFS----QSS------------------
------------------------------------------------------------
----------QRT-SR--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
----------------------------------------------------------MR
-SSVSRQTYST--------KGGFSSNSASGG---GGSQART-SFSSVT-VSRNSGSGGG-
--------------------------A--------------RCGPSTGGFGSRSLYNLGG
H-KSISVSVAGGASSG-RAL----------------------------------------
--------------GGFGFG------------------SRAFT-----------------
-------GQG-------AGRQTFGP-TC--PPGGI------QEVTVNQSLLTPL----HV
EIDPEIQR--VRTQEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQGQNLG--VTRNNV--EPLFE-AYLGSMRSTLDRLQS
ERGRLDSELRN-VQDLVEDFKNK-YEDEINKRTA---AENEFVVLK--K---DVDAAYMG
RMDLHGKVGTLTQEIDFLQQLYEM-----ELSQVQTHVSDT----NVVLSMDNNRNLDLD
SIIA-EVKAQYELIAQ-RSRAEAEAWYQTK--YEELQVTAGKHGDNLRDTKNEIAELT--
RTIQRLQGE-V--DAAKK------------------------------------------
-----Q-CQ--QLQTAIEEAEQ-RGELAL-KDAQKKL----GDLDVALHQAKEDLARLLR
DYQELMNVKLALDVEIATYRKLLESEE--------------------------S-RMS-G
ECPSA---V--------SISVTGNSTTVCG------------------------------
-----------------G---------------------GIALGGN---GG--ATKGGFS
TN----------------------------------------VGYGT----------V--
KGGPVSG--GTSILRKT--TTVKTSSRRY-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSL
H-------------F---GSQVFSSRSAAFPGR----GAPV-RL----------------
-------------------------------------------------------AGLG-
------------AS-RPQVAA--RS-----------------------------------
---------------SYG------------------------------------------
----------------A-------P-----VGTGI------SAVTINQSLLTPL----QV
DIDPSIQQ--VRQEEREQIKTLNNKFASF------IDK--VR------------------
----FLEQQNK-LLETKWTLLQEQKSA-----KSNRL--PGIFE-AQIAGLRKQLEALQL
DGGRLEVELRN-MQDVVEDFKNK-YEDEINRRTA---AENEFVVLK--K---DVDVAYMN
KVELEAKVDGLNDEINFLRTLYEQ-----ELKELQSEVSDM----SVVLSMDNNRSLDLE
SIIA-EVKAQYEEIAN-RSRAEAEACYQTK--FETLQAQAGKHGDDLRNTRNEIADMN--
RAIQRLQAE-I--DNIKN------------------------------------------
-----Q-RA--KLEAAIADAEQ-RGELAV-KDARAKQ----EDLEAALQKAKQDMTRQLR
EYQELMNIKLALDIEIATYRKLLEGEE--------------------------S-RLT-G
DGVGA---V--------NISV---------------------------------------
----VSS----------TGG----------------SGSRLTFGG-----TMGNNALRFS
SG-----GGPGT------------------------------------------------
--------LKAYSMRTTSATSRSPRN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---------------------------------------------------------MSI
R--VTQKSYK--VS--TSGPRAFSSCCYTSGPG-----ARI-SFSSF-------------
-------------------------------------------------------SRVGS
-----------------------S-----------SFWGG------------LGR-----
---------------GYG------------------------------------------
-----------------GASG----------MGGI------TAIMVNQSLLSPL----DL
EVDPNIQ A--MHM QEKEQIKTLS-KFVSF------IDK--VW------------------
----FLQQQNK-MLETKWSLLQQ-QEM-----AQSNM--DNLFE-SYINNLRQQLETLGQ
EKLKLETELGN-IQGLVEDFKNE-NEDEINKHTE---MANEFVLIK--K---YVDEAYMN
KVELESRLEGLTDKINFLRQLYEE-----EIQKLHSQISDT----SVVLSMDNSRSLDME
SIIA-EVKVQYEEIAN-RSLAEAESMYQVK--YEELQSLAGKPGDDLRRTKTEISEMN--
QNISRLQAE-I--EGLKG------------------------------------------
-----Q-KA--SLWRPPSQMQRNMGSWTLRMPTSRDA----SELEATPQQVKQDMARQLR
EYQELMNVKLALDIEMSPTGGCWRARRA---------------------------S----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
----------------------------------------------------------MR
-SSLSRKTYAT--------KGGFSSNSASGG---RGSRTHT-SFSSTT-MSRSSSSGGG-
--------------------------V--------------HCGPRMGGFGSRSLYNLGG
S-KSISVSMA---SSG-RGL----------------------------------------
--------------GGFGLG------------------SGPYG-----------------
-------GLG-------AGKQTFGP-VC--PPGGI------QEVTVNQSLLTPL----NV
EIDPEIQR--VRTQEREQIKILNNKFASF------IDK--VR------------------
----FLEQQNK-VLETKWALLQEQGQTRG--VTRNSL--EPLFE-IYVNGLRRTLENYQG
ERGRLDSELKN-VQEGLEDFKNK-YEDEINKRTA---LENEFVVLK--K---DVDAAYMA
KTELQGTVESLQQEIDFRHRLYEL-----VRWRVDGVIC-------------IHLHAALN
IIIA-EVKAQYELITQ-RSRAEAEAWYQTK--YEELQVTAGKHGDNLRDTKNEIAELT--
RTIQKLQGE-T--DAAKK------------------------------------------
-----Q-CQ--QLQEAIAESEE-RGELAL-KDAKKKL----GDLDAALHQAKEDLARLLS
DYQALLNVKIALDVEIATYRALLESEE---------------------------------
KCPSA---V--------SISVTGNSTTVCG------------------------------
-----------------GS--------------AAGFGGGISLGGG---VG--ASKGGFS
TN----------------------------------------MGCGT----------V--
KGGP-SG--GTSILRKT--TTVKTSSRRY-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

Query Results

"ENSGT00760000118796_0"

ENSGT00760000118796_0