ENSGT00750000117218_4 : Linker Region Query Results

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-GARPA--SPDRFAVSAEA-ENKVREQQPHVERIFSVGVSVLP---------KDCPDNPH
IWLQLEGPKENASRAKEYLKGLCSPELQDEIHYPPKLHCIFLGAQGFF-LDCLAWSTSAH
----------L---VPRAPGSLMISGLTEAFVMAQSRVEELAERLSWDFTPGPSSGASQC
TGVLRDFSALLQSPGDAHREALLQLPLAVQEELLSLVQEASSGQGPGA----LASWE-GR
S----S-------ALLGAQC--Q----GVRAP-PSDG----RESLD------TGSMGPGD
CR------------------------------------------GAR--GDT--------
----------------------------------Y----AVEKEGGKQGGPREM----DW
GWKELPGE-------------------------------------EAWERE------VAL
R-----------PQSVGG----------------------------------GA-RES--
-----APL-KGKALGKEEIA----------------LGGGG-FCVHRE---PPGAHGSCH
RAA-----------------------------------------QSRGASLLQRLHN--G
NASPPRV-----------------------------------------------------
-------------PSPPPA-----------------------------------------
--------------PEPPWHCGDRGDCGDRGDVGDR------------------------
------------------------------------------------------------
------GDK----------QQG---------------MARGRG----P--Q---------
--------------------------WKRG------ARG-----G-NLVTGTQRFKEALQ
DPFTLCLANVPGQPDLRHIVIDGSNVAMVHGLQHYFSSRGIAIAVQYFWDRGHRDI----
TVFVPQWRFSKDAKVRESHFLQKLYSLSLLSLTPSRVMDGKRISSYD-------DRFM-V
KLAEETDGIIVSNDQFRDLAEESEKWMAIIRER---------------------------
LLPFTFVGNL------FMVPDDPLGRNGPTLDEFLKKPART-QGSS-KAQHPSRGFAEHG
----------------------------------KQQ-----------------------
---------------Q--G-REEEKGSGG--IRKTRETERLRRQLLEVFWGQDHKV---D
FIL---------------QREPYC-RDINQLSEALLSLNF--------------------
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--------------------------------------------------------MPTW
-EARPA--SPDRFAVSADA-ENKVREQQPHVERIFSVGVSVLP---------KDCPDNPH
IWLQLEGPKENASRAKEYLKGLCSPELQDEIHYPPKLHCIFLGAQGFF-LDCLAWSTSAH
----------L---VPRAPGTLMISGLTEAFVMAQSRVEELTERLSWDFTPGPSSGASQC
TGVLRDFSALLQSPGDAHREALLQLPLAVQEELLSLVQEASSGQGPGA----LASWE-GR
S----S-------GLLRAQC--Q----EERAP-PSDG----RESLD------TGSVGPRD
SR------------------------------------------GAR--GDN--------
----------------------------------Y----VVEKEGGKQGGPREM----DL
GWKELPGE-------------------------------------EAWERE------VAL
R-----------PQSVGG----------------------------------GL-RES--
-----APL-KGKALGKEEVT----------------QGGGG-VCVHRE---PPGAHGSCH
RAA-----------------------------------------QSRGASLLQRLHN--G
NASPPRV-----------------------------------------------------
-------------PSPPPA-----------------------------------------
--------------PEPPWHCGDRGDWGDRGDGGDR------------------------
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------GDK----------QQG---------------MARGRG----P--Q---------
--------------------------WKRG------ARG-----G-NLVTGTQRFKEALQ
DPFTLCLANVPGQPDLRHIVIDGSNVAMVHGLQHYFSSRGIAIAVQYFWDRGHRDI----
TVFVPQWRFSKDSKVRESHFLQKLYSLSLLSLTPSRVMDGKRISSYD-------DRFM-V
KLAEETDGIIVSNDQFRDLAEESEKWMAIIRER---------------------------
LLPFTFVGNL------FMVPDDPLGRNGPTLDEFLKKPART-QGSS-KAQHPSRGFAEHG
----------------------------------KQQ-----------------------
---------------H--G-REEEKGSGG--IRKTRETERLRRQLLEVFWGQDHKV---D
FIL---------------QREPYC-RDINQLSEALLSLNF--------------------
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--------------------------------------------------------MRL-
--SGGEPPALEWFMVQTKS-KPRVQRQRLQVQRIFRVKLNAFQ----------SRPDTPY
FWLQLEGPRENTSKAKEYLKGLCSPELWKEVRYPPMLHCAFLGAQGLF-LDCLCWSTLAY
----------L---VPGPPGSLM-------------------------------------
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------QKEDSAVVSTGESPG---SFLETGTLQ-----NGGPEN--PKRLSSLGATRSLI
---------PVQSTQQ----------ETANQVVRVGSNNQ---SG-TDSDREEGL---VR
ATSRQNSVNRTPA--------LLQQNQVQKIEDK--FPFQP--PVSALGMCPSWKAWTPG
PA--------FGPLWPGT------IAAAFWRIN---ELHS----LHLACLLSQACFSLPF
WQ-RPLGPIQLKLPGQSPLPLNLEWKQKELAPLPSAESPACRPDGELG---VEATLQNCP
RPETPP-KVMSLLVVPGGSGEKDKVSPTLPPLAS--AAQ--LQGGGEQRNQGS-LQPDCM
WLEKGPPPAPPTEQRVP------TAEGRHVAQGGLTVQSVPEAGTVPEALEVPMAAVVPK
AENPPLTQGQPAAPEVPLT-----------------------------------------
--------------LTMP------AAQVVST-AQKAAVVQPAL--ASATQVMSTTLKTAI
AQKMLA---TKTSPASPKTLKAQTGPVTKMGSA--VPKASAA------PKTSAAPKAPAA
SKASRSPKT--------PGDQK------ASSKVARLLTEVQPSSRGDASLPKDQGEP-GR
QVAQPSSK-----------HQLLGS-WEWGPRQSPRYPQ-----ANSTVTSFQRYHEALN
TPFELNLSGEPGNQELRRVVIDGSSVAMVHGLQHFFSCRGIAMAVQYFWNRGHREV----
TVFVPTWQLKKNRRVRESHFLTKLHSLKMLSITPSQLENGKKIATYD-------YRFM-V
KLAEETDGIIVTNEQIHTLMNNS-RKLMV-KDR---------------------------
LLPFTFAGNL------FMVPDDPLGRDGPTLDEFLKKPNRLDTDIGNFLKV----WKTLP
PSSDGISELSDD-TDPRPLQGAQNVEEVREEKEERQDEEWR-------------------
---EGQG---------MPEWAEEDDLDSSLASVFRVECSSLSEEILQCLSLHDPPDGALD
IDLLPGVASPYLGIPWD--GKAPCQQVLAQLAQLTTPSNFTVLSFFVGFMDSHQDVIPDY
EALMGPLHSLLKQKPDWQWDQEHEKAFLALKRALVSALCLTAPNSQMPFRLQVTVSQVAL
TAVLCQEHSGKKHPIAYTSKPLLPDEDSEGPQSGGDSPYAVAWALKHFSRCIGDDPVVLN
LAYASRTTVSPQAPEGRRVSKAWLIRWSLLVQDRGKRVLELALLQGLLGENRLLTPA-SS
MPRFFQVLPPFSDLSTFVCIHMSGYCFYREDEWCAGFGLYVLSPTSPPVSLSFSCSPYTP
TYAHLAAVACGLERFGQSHLPVVFLTHCNWIFSLLWELLPLWKARGF-LSSDGAPLPHPS
LLSYIISLTSGLSSLPFIYRTSYRSSLFAVTVDNLAKQGAQGGGQWWNLPKDVLVP-VVT
PRTMVKRPNLLALQLSDSTLADIITKLRVGQKLSGSSPFSSAFNSLSLDKQSGLLMFKGD
KKPKVWVVPRQLRRDLVFSVHDIPMGAHQRPEETYKKLQLLGWWPGMQEHVKDYCRSCLF
CIPRNLTGSELKVIESPW---P--LRS--TAPWSNLQIEVVGPVTISEEGHRHVLIVADP
NTRWVEAFPLKPYTHMAVAQVLLQHVFARWGVPVRLEAAQGPQFARHVLVSCGLALGAQV
TSLSRDLQFPCLVSSEAYWEFKRALKEFIFLHGRKWAASLPLLHLAFRASSAEATPFQVL
TGGERRLTGPLWWEMSSANIEGLKMDVFLLQLIGELLELHWRVAEKGTEK---ADNRRFK
QESQEKEWNVGDQVLLLTLPRNGSSAKWVGPFYIGDRLSLSLYRVWGFPTPEKLGCIYPS
SLMKPFAKSGTPLSFKVMEQ----

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--------------------------------------------------------MLL-
--SGGDPPAQEWFMVQTKS-KPRVQRQRQQVQRIFRVKLNAFQ----------SRPDTPY
FWLQLEGPRENMGKAKEYLKGLCSPELWKEVRYPAALHCAFLGAQGLF-LDCLCWSTLAY
----------L---VPGPPGSLMVGGLTESFIMTQNWLEELVGRLRWGPAPLLTPRGIWE
AEVTRAFGALVWIRGDQYAGDLLQLPPAVQELLLSLVRDAAGKEDI-IQWLSRIGTSDSR
---SDP-------ELLI-------------------------------------------
-CPTHQQKEGPTMVAVGDGPG---PFVEMG----------SPEN--SKRLTSLGATGAVI
SGT------PGPNTQQ----------ETANQLVRVTSNNQ---GG-VDCSREEGS---VQ
ASSSQDPVDHTQA--------SSQQRQVRRGEDK--LPLQP--PVSALSVCSPWKAWTPG
PT--------FAPMWPGA------IAATFWRIN---ELHS----LHLAWLLSQACFSFPF
WQ-RPLGPIQFKLPGQNPLPLNLGWKQKELVPLPSVESPDCTPDGGPG---GEAALQNCP
GPETPK-KVVSLLVVSGGSGVKDKSIPGLPQIGPPLTSTPQLQARSELGDQGS-VQWDCK
GPEEGPDAAPPTGQGVPAAQGEGRGSGIV-----RGQKRGPMQLRVPETLKVPMAAAMPT
AQTPPTSPALPAAPKVPETQMK-A-AHEERAASEVPS-----------------------
-------------VPTKPA------AQVVPT-AQKA-----------------AAPHTPA
AQKRQA---AKASPTGPQSRG-----LPLKP--------------------PTAPKAPAA
PQTSRTPKM--------PVAQKAPAGPGSTLDAGKLVSEGQPPSRGSASFLKGQGQP-GS
QGPQCSGTLAPSSKRQPQVEGLLGA-GEGTPRQPTRHPQ-----ASNTVTSFQRYHEALN
TPFELDLSEEPGNPELRRVVIDGSSVAMVHGLQHFFSCRGIAMAVQYFWNRGHREV----
TVFIPTWQLKKNRRVRESHFLTKLHSLKMLSITPSQLENGKKITTYD-------YRFM-V
KLAEETDGIIVTNEQLHVLMNNS-KKLMV-KDR---------------------------
LLPFTFAGNL------FMVPDDPLGRDGPTLDEFLKKPNRLDTDIGNFLKV----WKTLP
PSSASISELRDD-TDPGPPESLQNVEEVREEQEEEER---------QDE---EQ------
--REEQEMQ---KP----AEEEEEDLDSSLMSVFRAECPSLSEEILRCLSLHDPQDEALD
IDLQPAVASPSLGIPWD--GKAPCQQVLAQLAQLTIPSNFTALSFFMGFTDSHRDVIPDY
EALVAPLHSLLKQKPDWRWELDHEKAFLALKRALVSALCLSVPNPQLPFHLEVTVSQVAL
TAVVYQEHSGRKHPVAYTSKPLLPDEDSEGPQSGGDSPYAVAWALKHFSRYIGDTPVVLD
LFYASRTSVDPEAWDGRRVAKAWLIRWALLVQDKGKRALELTLLQGLLGKNRLLTPT-AC
MPRLFQVLPPFSDLSTFVCIHMSGYCFYREDEWCAGFGLYVLSPTSAPVSLSFSCSPYTP
TYAHLAAVACGLERFGQSHMPIVFLTHCNWIFSLLWELLPLWRARGF-LSSDGTPLPHPS
LLSYIIDLTSGLSSLPFIYRTSYRGSLFAVTVDTLAKEGAQGGDQCWNLPNDVPAP-IVT
PRTVCKRPDLLALQQSDSTLADIMAKLQAGQKVSNSSPFSSAFSSLSLDKESGLLMFKGD
KRPRVWVVPRQLRRDLIFAVHDGPMGAHQRPEETYRKLRLLGWWPGMQEHVRHYCRSCLF
CIPRNLLGSEVKVIESLW---P--LRS--TAPWSNLQIEVVGPVTVSEEGHKHVLIVADP
NTRWVEAFPLKPYTHTAVAQLLLQHVFARWGIPVRLEAAQGP----HVLVSCGLALGVHV
ASPSRDLQFPCLTSSGAYWEFKRALKEFIFLHGKKWAASLPLLHLAFRASSSQASPFRIL
TGAEERLTEPLWWEMSSANIEGLKMDLFLLQLTRELLELHWRLAEKTSEK---AENRRFK
RERQEKEWNVGDQVLVLSLPRNGSSAKWVGPFYIGDRLSPSLYRVWGFPTPEKLGCIYPS
SLMKPFAKSVTPLSFKVLEQ----

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-ESGSP--SPDRFAVSAEA-EGKVRELQPHVQRIFGVGMSILP---------KDCPENPH
IWLQLEGPKENASRAKEYLKGLCSPELQDEIHYPPKLHCIFLGAQGFF-LDCLTWSTSAH
----------L---VPGAPGSLMISGLAEAFVMARSRLEELVERLSWDFLPGLSPGDSQC
AGVLRNFFALLQSREDAHRQALLQLPLAVQEELLSLVQEASGGQGPQA----LPSWE-GR
S----P-------GFLSSQC--L----GVRAP-SSDA----RESLD------AGSMGLGE
SK------------------------------------------GAR--GES--------
----------------------------------Y----AVEKEGGKESRPGEM----DL
GWKELPGE-------------------------------------EAWERE------GAF
R-----------PQSGGG----------------------------------GV-REA--
-----GPL-KGKALGKEGVP----------------QERGG-ICVQDE---PPGVRGSCQ
RAA-----------------------------------------QARGATLLQRLHN--G
NASPPRV-----------------------------------------------------
-------------PSPPPA-----------------------------------------
--------------PEPPWHCGDRSDR------GDG------------------------
------------------------------------------------------------
------GDK----------QQA---------------MARSRG----S--P---------
--------------------------WKRG------TRG-----G-NLVTGTQRFKEALQ
DPFTLCLANVPGQPDLRHIVIDGSNVAMVHGLQHYFSSRGIAIAVQYFWDRGHRDI----
TVFVPQWRFSKDSRVRESHFLHKLYSLSLLSLTPSRVMDGKRISSYD-------DRFM-V
KLAEETNGIIVSNDQFRDLAEESEKWMAIIRER---------------------------
LLPFTFVGNL------FMVPDDPLGRNGPTLEEFLKKPDGT-PGFS-KAQPPSRGFTEHD
----------------------------------NKQ-----------------------
---------------Q--G-REEEKGSGG--IRKTRETERLRRQLLEVFWGQDHKV---D
FIL---------------QREPYC-RDINQLSEALLSLNF--------------------
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--------------------------------------------------------MCTR
-GFASP--TPDRFAVSAVA-EDKVREQQARLERIFSVGMSVLS---------KDCPENPH
IWLQLEGPKENVCRAKEYLKGLCSPELQSEVRYPPRLHCVFQGAQGFF-LDCLAWSTSAH
----------L---EPLAPGSLMVSGLTEAFVMAQSRVEELVQRLSWDLQLPPCSGASAG
AGVLSDFSALLHSKEDAYTEALLQLPLAVQEELLSLVQEAFREQG--------PQRE-RG
S----P-------GLLSAQF--Q----QVRAP-LNEG----GESLG------SGVAGLGE
SR------------------------------------------AAP--GGS--------
----------------------------------R----TVEKGGRKQDAVRDT----YS
GQKETPGE-------------------------------------EVGERG------VAF
K-----------SRPAGT----------------------------------GA-EE---
-----VAPLKGKALGKEEVP----------------QQRGG-FGVQGE---PSGAPVPTQ
RAA-----------------------------------------QIRGASLLQRLHN--G
NTSPPRV-----------------------------------------------------
-------------PSPPSA-----------------------------------------
--------------PEPPWPCGDR------D-RG--------------------------
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-------DK----------QQA---------------GARGRG----S--P---------
--------------------------WKRG------TRG-----G-NLVTGTQRFQEALQ
DPFTLCLANVPGQPDLRHIVIDGSNVAMVHGLQHHFSSRGIALAVQYFWDRGHRDI----
TVFVPQWRFSKDSKVRESHFLQKLYSLSLLSLTPSRVMDGKRISSYD-------DRFM-V
KLAEETDGIIVSNDQFRDLAEESDTWMAIVRER---------------------------
LLPFTFVGNL------FMVPDDPLGRNGPTLDEFLKKTVRK-QGSA-KTQQPSRGPTDHG
----------------------------------NQQ-----------------------
--------------QGKQGKEEERGS-SG--IRKTRETERLRRQLLEVFWGQDHKV---D
FIL---------------QREPYC-RDINQLSEALLSLNF--------------------
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--------------------------------------------------------MSTW
-GFASP--TPDRFAVSAEA-EDKVREQQTRLERIFNVGMSVLS---------KDCPENPH
IWLQLEGPKENVCRAKEYLKGLCSPELQSEIHYPPRLHCIFLGAHGFF-LDCLAWSTSAH
----------L---VPLLPGSLMISGLTEAFVMAQSRVEELVQRLSWDLQLQSCPGAPDN
GGVLRDFSALLQTREDAYTEALLRLPLAVQEELLSLVQEASRGQGP--------SRE-VG
S----S-------GLLSPQF--Q----GVRAP-LNEG----REFVG------TRVAGSGK
SP------------------------------------------AVR--GQS--------
----------------------------------H----TVEKEERKQDAVRDM----GS
GRKELSGE-------------------------------------EVWEPG------VAY
R-----------SQLAGG----------------------------------GA-EE---
-----VAPLKGKASGKQEVP----------------QQRGG-FSVQGE---PSGAHVPCQ
RAA-----------------------------------------PIRGASLLQRLHN--G
SASPPRV-----------------------------------------------------
-------------PSPPPA-----------------------------------------
--------------PEPPWPCGDRDR--DRD-RGDR------------------------
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------GDK----------QQA---------------GARGRG----S--P---------
--------------------------WKRG------TRG-----G-NLVTGTQRFQEALQ
DPFTLCLANVPGQPDLRHIVIDGSNVAMVHGLQHYFSSRGIALAVQYFWDRGHRDI----
TVFVPQWRFSKDSKVRESHFLQKLYSLSLLSLTPSRVMDGKRISSYD-------DRFM-V
KLAEETDGIIVSNDQFRDLAEESDKWMAIIRER---------------------------
LLPFTFVGNL------FMVPDDPLGRNGPTLDEFLKKPVRK-QGSS-KTQQPSKGSTEQA
----------------------------------NQQ-----------------------
--------------QGKDA---D-RSNGG--IRKTRETERLRRQLLEVFWGQDHKV---D
FIL---------------QREPYC-RDINQLSEALLSLNF--------------------
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-EALPV--SPDRFAVSAEA-ETKVREQQPHVERIFSVGVSVLP---------KDCPDNPH
IWLQLEGPKENASRAKEYLKGLCSPELQDEIRYPPKLHCIFLGAQGFF-LDCLTWSTSAH
----------L---VPREPGSLMISGLTEAFVMAQSRVEELVERLSWDFLPGPSPGASQC
PGVLRDFSALLHSPGDAHRDALLQLPLAVQEELLSLVQEASSGQGPGA----LASWE-GR
S----S-------GLLGAQC--Q----GVRAP-PSDG----RESLD------TRSVGPRE
SR------------------------------------------GAR--GDS--------
----------------------------------Y----AVE-KGGKQGGPREM----AF
GWKELPGE-------------------------------------EAWERE------IGL
R-----------PQSVGR----------------------------------GA-RES--
-----APL-KGKTLGKEEAT----------------QGGGG-VCVHRE---PPSAQGSCH
RAA-----------------------------------------QSRGASLLQRLHN--G
NASPPRV-----------------------------------------------------
-------------PSPPPA-----------------------------------------
--------------PEPPWHCGDRGDWGD---GGDR------------------------
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------GDK----------QQT---------------TARSRG----P--H---------
--------------------------WKRG------ARG-----G-NLVTGTQRFKEALQ
DPFTLCLANVPGQPDLRHIVIDGSNVAMVHGLQHYFSSRGIAIAVQYFWDRGHRDI----
TVFVPQWRFSKDAKVRESHFLQKLHSLSLLSLTPSRVMDGKRISSYDDSCCGFGDRFM-V
RLAEERDGIIVSNDQFRDLAEESENWMAIIRER---------------------------
LLPFTFVGNL------FMVPDDPLGRNGPTLDEFLKKPART-QGPS-KTQHPSRGFAEHG
----------------------------------KQQ-----------------------
---------------Q--G-REEEKGSGG--IRKTRETERLRRQLLEVFWGQDHKV---D
FIL---------------QREPYC-RDINQLSEALLSLNF--------------------
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-EARPA--SPDRFAVSAEA-ENKVREQQPHVERIFSVGVSVLP---------KDCPDNPH
IWLQLEGPKENASRAKEYLKGLCSPELQDEIHYPPKLHCIFLGAQGFF-LDCLAWSTSAH
----------L---VPRAPGSLMISGLTEAFVMAQSRVEELTERLSWDFMPGPSSGASQC
TGVLRDFSALLQSPGDAHREALLQLPLAVQEELLSLVQEASSGQGPGA----LASWE-GR
S----S-------GLLGAQC--Q----EERAP-PSDS----RESLD------TGSVGPRD
SR------------------------------------------GAR--GDN--------
----------------------------------Y----AVEKEGGKQGGPREM----DL
GWKELPGE-------------------------------------EAWERE------VAL
R-----------PQSVGE----------------------------------GL-RES--
-----APL-KGKALGKEEVT----------------QGGGG-VCVHRE---PPGAHGSCH
RAV-----------------------------------------QSRGASLLQRLHN--G
NASPPRV-----------------------------------------------------
-------------PSPPPA-----------------------------------------
--------------PEPPWHCGDRGDWGDRGDGGDR------------------------
------------------------------------------------------------
------GDK----------QQG---------------MPRGRG----P--Q---------
--------------------------WKRG------ARG-----G-NLVTGTQRFKEALQ
DPFTLCLANVPGQPDLRHIVIDGSNVAMVHGLQHYFSSRGIAIAVQYFWDRGHRDI----
TVFVPQWRFSKDSKVRESHFLQKLYSLSLLSLTPSRVMDGKRISSYD-------DRFM-V
KLAEETDGIIVSNDQFRDLAEESEKWMAIIRER---------------------------
LLPFTFVGNL------FMVPDDPLGRKGPTLDEFLKKPTRT-QGSS-KAQHPSRGFAEHG
----------------------------------KQQ-----------------------
---------------Q--G-REEEKGSGG--IRKTRETERLRRQLLEVFWGQDHKV---D
FIL---------------QREPYC-RDINQLSEALLSLNF--------------------
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--------------------------------------------------------MLW-
--SGGELPAQEWFMVQTKS-KPRVHRQRLQVQRIFRVKLTAFP----------SRPDTSY
FWLQLEGPRENTGKAKEYLKGLCSPELWKEVRYPPVLHCAFLGAQGLF-LDCLCWSTLAY
----------L---VPGPPGSLMVGGLTESFTMTQNWLEELVARLRWGPAPLLTPRGIWE
AEVTRAFGALVWIRGDQYSGDLLQLPPAVQELLLSLVRDAAGKEDI-IEWLSHFGISSIC
---SDP-------EVLI-------------------------------------------
-CPSQQQKQGTTVVSIGESPT---PFLEIGALP-----RGGSEN--PRTLTSLGATASLI
---------PVQSTQQ----------ETANQLVRVCPNNQ---GD-KDRTQEEGLD--MQ
ATSSQDSANHTQ------------QKQVQRMKDR--FSFQP--PVSALGVGTSWKAWTPG
PT--------FGPLWPGS------IAATFWRIN---ELHS----LHLAWLLSQA-FNFPL
WQ-RPLGSIQLKLPGQNSLPLNLEWKQKELIPLPSAESPTCRPDGETG---GETALQNCP
RPESPP-KVMSFLLVPGGCGIKDKVSLGLPQVGPSLTITPQVQDE------------DYK
GLEKGSSPALLPQKGVP-------------------------------------------
-----TAQGPPAAPKVPTAQKTMA-VHTEPAVPSAPT-----------------------
-------------KPAAPHM---------PT-AQKT--------------------STPT
GQKMPAVK---T-SAAPHSCTAQTVPTVKTG--------------SAVSKTPGAPKTHAA
SKTSRASKA--------SATQKASTASGTNLDVAKLLGELQPSSRGSANLTKGQGKA-GR
QGPQASNTLASSSKHQFLKEGLLGA-WEEGLRQSPHHPR-----ANNTVTSFQRYHEALN
TPFELNLSEEPGNLGLRRVVIDGSSVAMVHGLQHFFSCRGIAMAVQYFWNRGHREV----
TVFVPTWQLKKSRRVRESHFLTKLHSLKMLSITPSQLEKGKKITTYD-------YRFM-V
KLAEETDGIIVTNEQIHILMNHS-KKPMV-KDR---------------------------
LLPFTFAGNL------FMVPDDPLGRDGPTLDEFLRKPNRLDMDIGNFLKV----WKTLP
PRSSSIFELSDD-ADPGPVEGSEDMEEVRKEKEERSGMQ---------------------
------------------KLAEEDNPDSSLASVFGAECPSFSEEILRCLSLDEPFNGALD
IDLLPGVASPYLGVPWD--GKAPCQEVLSQLAQMTIPSNFTALSFFVGFMECHRDVIPDY
EVLVGPLHGLLKQKPDWQWDPEHEKAFLALKRALVCVLCLSAPNSELPFHLEVTVSQVAL
TAVLHQEHSGRKHPIAYTSKPLLPDEDSEGPQSGGDSPYAVAWALKHFSCCIGDTPVVLG
LSYASRTTVDPKAQEDCGASRAWLIRWSLLVQDKGKRALELTLLQGLLGENRLLTPA-SS
MPRFFQALPPFSDLSAFVCIHMSGYCFYHDDEWCAGFGLYVLSPTSPPVSLSFSCSPSTP
TYAHLAAVACGLERFSQSHFPVVFLTHCNWVFNLLWELLPLWRARGF-LSSDGAPLPHPS
LLSYIISLISGLSSLPFIYRTSYRGSLFAVTVDTLAKQGAQGNGEWWNLPKDVPVP-VVT
PHTMCRKPNLLALQLSDSSLADIIVKLQAGQKLSGSSPFSSAFNSLSLDKESGLLMFKGE
KKPRVWVVPRQLRRDLIFSVHDIPMGAHQRPEETYKKLRLLGWWPGMQEHVKDYCRSCLF
CISRNLIGSELKVIESPW---P--LRS--TAPWSHLQIEVVGPVTISEEGHKHVLIVADP
NTRWVEAFPLKPYTHMAVAQVLLQHVFARWGVPVRLEAAQGPQFARHVLVSCGLALGAQV
ATLSRDLQFPCLISSEAYWEFKRALKEFIFLHGKKWAASLPLLHLAFRASSTQATPYQVL
TGGEVKLTEPLWWEMSSANIEGLKMDAFLLQLVGELLELHGGVAEKASEK---AEYRRFK
RESQEKEWNVGDQVLLLSLPRNGSSAKWVGPFYIGDRLSLSLYRVWGFPTPEKLGCVYPS
SLMKAFAKSGTPLSLKVLEQ----

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--------------------------------------------------------MLL-
--SGGDPPAQEWFMVQTKS-KPRVQRQRLQVQRIFRVKLNAFQ----------SRPDTPY
FWLQLEGPKENMSKAKEYLKGLCSPELWKEVRYPQALHCAFLGAQGLF-LDCLCWSTLAY
----------L---VPGPPGSLMVGGLTESFIMTQNWLEELVGRLRWGPAALLTPRGIWE
AEVTRAFGALVWIRGDQYAGDLLQLPPAVQELLLSLVRDAAGKEDI-IEWLGRIGTSESR
---SDP-------EVLI-------------------------------------------
-CPPHQQKEGPAMVSVGDGPG---PFLEVGAFQ-----NKSLEH--SKRLTSLGATRALV
SGT------PGQNIQQ----------ETTNQLVRVDSNSH---GG-TDSPREEGP---AR
ATGSQDSANHTQA--------LSQPRQGLRVEDK--LPFQP--PVSALGVCPPWKAWTPG
PA--------FGPLWPGA------IAATFWRIN---ELHS----LHLAWLLSQACFSFPF
WQ-RPLGPIQFKLPGQNPLPLNLEWKQKELVPLPSMGSPDCRPDGGPG---GDAALQSCP
RPETPQ-KVMSLLVVSG-ASVKDKTSPGLPQIGPPLTSVPQLQTGSEPGDQGS-LQWDCK
GPEEGPFPALPIEQGVS------TPQGRPVAQGGLTPQSVPDAQTVPETLEVPMAAAVPT
AQTPPADQGLSAVPKVPTAQTTLA-VHTEPAALEVPS-----------------------
-------------ATTKPAAQG------VPT-TQKAAEGLPVS----AAPVVPATPKASA
AQKTSA---AKSLPVGPQTPKAQTGPAAKTGSV--APKAPAAPKAPATPKAPAAPKAPAA
PKASKAPKT--------PAAQKTPTDPGPVLDAAKL-SEGQPSSRGGASFPKGQGEA-ER
QGPHSGSTFAPSSKHPPQMEGLLGA-REGTARQQPRHPQ-----ANSTVTSFQRYHEALN
TPFELNLSGEPGNQGLRRVVIDGSSVAMVHGLQHFFSCRGIAMAVQYFWNRGHREV----
TVFVPTWQLKKNRRVRESHFLTKLHSLKMLSITPSQLENGKKITTYD-------YRFM-V
KLAEETDGIIVTNEQLHILMNNS-KKLMV-KDR---------------------------
LLPFTFAGNL------FMVPDDPLGRDGPTLDEFLKKPNRLDTDVGNFLKV----WKTLP
PSLASASEPSDG-ADPVPVESLQNTEEVRAEKEERQQD----------G---EQ------
--REGQGVR---EP------PEEDALDSSLASVFRAECPSLSEEILRCLSLQDPPDGALD
IDLLPAPASPYLGIPWD--GKAPCQQVLAQLAQLTIPSNFTALSFFVGFMDSHRDVIPDY
EALVGPLHSLLKQKPDWQWDWEHEKAFLALKRALVSALCLTAPNAQLPFRLEVTVSQVAL
TAVVYQEHSGRKHPIAYTSKPLLPDEESEGPQSGGDSPYAVAWALKHFSRCIGDTPVVLD
LSYASRTAVGPEMREGRRVSKAWLIRWSLLVQDKGKRALELTLLQGLLGENRLLTPA-SS
MPRFFQVLPPFSDLSTFVCIHMSGYCFYREDEWCAGFGLYVLSPTSAPVSLSFSCSPYTP
TYAHLAAVACGLERFGQSPLPVVFLTHCNWIFSLLWELLPLWQARGF-LSSDGAPLPHPG
LLSYIISLTSGLSSLPFIYRTSYRGSLFAVTVDTLAKQGAQGGGQWWNLPKDVPVP-AVS
PHTMGQRPDLLALQRSDSTLAEIIAKLRAGQKLPGSSPFSSVFNSLSLDQESGLLMFKGE
KRPRVWVVPRQLRRDLIFSVHDLPLGAHQRPEETYRKLRLLGWWPGMQEHVRDYCRSCLF
CIPRNVTGGELKVIESPW---P--LRS--TAPWSTLQIEVVGPVTVSEEGHKHVLIVADP
HTRWVEAFPLKPYTHTAVAQVLLQHVFARWGVPVRLEAAQGPQFARHVLVSCGLALGAQA
ASLSRDLQFPCLTSSDAYWEFKRALKEFIFLHGKRWAASLPLLHLAFRASSTQATPVQIL
TGGDVRLSEPLWWEMSSANIEGLKMDVFLLRLLGELLELHWRVAEKASDK---AENRRFK
RESQEKEWNVGDQVLLLSLPRNGSSAKWVGPFYIGDRLSLSLYRVWGFPTPEKLGCIYPS
SLMKAFAKSGTPLSFKVLEQ----

------------------------------------------------------------
--------------------------------------------------------MLL-
--SGGRPPAQEWFMVQTKS-KPRVHRQRLQVQRIFRVKLNAFQ----------SRPDTPY
FWLQLEGPRENTGKAKEYLKGLCSPELWKEVRYPPILHCAFLGAQGLF-LDCLCWSTLAY
----------L---VPGPPGSLMVGGLTESFTMTQNWLEELVARLRWGPAPLLTPRGVWE
AEVTRAFGALVWIRGDQYAGDLLQLPPAVQELLLSLVRDAAGKEDI-IEWLGHFGISDAC
---SNP-------EVLV-------------------------------------------
-CPPQQQKEGSDIVTLGENPG---PFPEIGTFQ-----IGDSEN--SKTLTSLGATGSLI
---------PAQSTQQ----------ETACQLARVRSNNQ---RD-TDSDREEGPI--VQ
ATSNQDSANHTQA--------LLQQRQVQRMEDR--LSFQT--PVSALGVCPSWKAWASG
PT--------FGPLWPGT------IAATFWKIN---ELHS----LHLAWLLSQACFNFPF
WQ-RPLGPIQLKLPGQNPLPLNLEWKQKELAPLPSIESPACRPEGKLG---AEKALENCP
RSEGPP-KVMSLLVVPRNCGIKDKVSPRLPQVAQRST------------------LSDCK
GLKKQASAAPSA------EPRKPTAQGRPVAQGGVMAQSIPEAQTEPETLKMPMAAVEPI
AE------GLSAAPK-------------------VPS-----------------------
-------------GPAKPAAPV------VST-AQKSALT---------------------
-------------PAAPQTPV--------TPKAPTAPQTPVTPKAPAAPQTPATPKAPTA
SKISRASGT--------SAAQKMSKVAGPTLDVAKLLSEVQASSKSRAALPKGQGKA-GR
QGPQSSSTLASSSKHPFLKEGILGA-WDGAPRQ-----------ENSTVTSFQRYHEALN
TPFELNLSGEPGNPGLRRVVIDGSSVAMVHGLQHFFSCRGIAMAVQYFWNRGHREV----
TVFVPTWQLKKNRRVRESHFLTKLHSFKMLSITPSQLENGRKITTYD-------YRFM-V
KLAEETDGVIVTNEQIHILMNNS-KKLMV-KDR---------------------------
LLPFTFAGNL------FMVPDDPLGRDGPTLDEFLRKPNRLDMDIGNFLKV----WKTLP
PKSARISELSDD-ADPESLMDLQNVEEVEEEREKSLEEEP--------------------
-------WE---EPGLP-KLAEEHDLDSCLASLFGAKCPSFSEEILRCLSLHDPSEGALD
IDLLPGVSSPYMDDPWD--GKAPCQQVLAQLAQLTIPSNFTALSFFVGFMDSHRDVIPDY
EVLVGPLHSLLKQKPDWQWEREHEKAFLALKRALVSVLCLSTPNSQLPFHLEVTVSQVAL
TAILHQEHSGRKHPIAYTSKPLLPDEDSEGPQSGGDSPYAVAWALKHFSRCIGDSPVVLG
LSYASRTTVDSEALESCSVSKAWLIRWSLLVQDKGKRDLELTLLQGLLGENQLLTPA-SS
MPRFFQVLPPFSDLSSFVCIHMSGYCFYSEDEWCAGFGLYVLSPTSPPVSLSFSCSPPTP
TYAHLAAVACGLERFGQSHLPVVFLTHCTWIFSLLWELLPLWKARGF-LSADGASLPHPS
LLSYILSLTSSSSSLPFIFRTSYRGSLFAVTVDNLAKQGAQGGGQWWNLPKDVPVP-VVT
PCPKGRKPNLLALQLSDSTLADIIGKLKAGQKLTGSSPFSSAFNSLSLDKESGLLMFKGE
KKPRVWVVPRQLRRDLIFSVHDIPFGGHQRPEETYRKLRLLGWWPGMQEHVKDYCRSCLF
CIPRNLVGSELKVIESPW---P--LRS--TAPWANLQIEVVGPVTVSEEGHKHVLIVADP
NTRWVEAFPLKLYTHMAVAQVLLQHVFARWGVPVRLEAAQGPQFARHVLVSCGLALGAQV
ATLSRDLQFPCLMSSDAYWEFKRALKEFIFLHGKKWAASLPLLHLAFRASFTEATPCQVL
TGGEVRLPEPLWWEMSSANIEGLKMDVFLLQLIRELLELHWRVAEKASEK---AQNRRLK
RESQEKEWNVGDQVLLLSLPRNGSSAKWVGPFYIGDRLSLSLYRVWGFPTPEKLGCVYPS
SLMKTFAKSGTPLSLKVLEQ----

------------------------------------------------------------
--------------------------------------------------------MSTW
-GFASP--TPDRFAVSAEA-EDKVREQQTRLERIFNVGMSVLS---------KDCPENPH
IWLQLEGPKENVCRAKEYLKGLCSPELQSEIHYPPRLHCIFLGAQGFF-LDCLAWSTSAH
----------L---VPLLPGSLMISGLTEAFVMAQSRVEELVQRLSWDLQLQSCPGAPDN
GGVLRDFSALLQTREDAYTEALLRLPLAVQEELLSLVQEASRGQGP--------SRE-VG
S----S-------GLLSPQF--Q----GVRAP-LNEG----REFIG------TGVAGSGK
SR------------------------------------------AVR--GQS--------
----------------------------------H----TVEKEERKQDAVRDM----GS
GRKELSGE-------------------------------------EIWEPG------VTY
R-----------SQLAGG----------------------------------GA-EE---
-----VAPLKGKALGKQEVP----------------QQRGG-FSVQGE---PSGAHVPCQ
RAA-----------------------------------------PTRGASLLQRLHN--G
SASPPRV-----------------------------------------------------
-------------PSPPPA-----------------------------------------
--------------PEPPWPCGDRDR--DRD-RGDR------------------------
------------------------------------------------------------
------GDK----------QQA---------------GARGRG----S--P---------
--------------------------WKRG------TRG-----G-NLVTGTQRFQEALQ
DPFTLCLANVPGQPDLRHIVIDGSNVAMVHGLQHYFSSRGIALAVQYFWDRGHRDI----
TVFVPQWRFSKDSKVRESHFLQKLYSLSLLSLTPSRVMDGKRISSYD-------DRFM-V
KLAEETDGIIVSNDQFRDLAEESDKWMAIIRER---------------------------
LLPFTFVGNL------FMVPDDPLGRNGPTLDEFLKKPVRK-QGSS-KSQQPSKGSTEHA
----------------------------------NQQ-----------------------
--------------QGKEA---E-RSNGG--IRKTRETERLRRQLLEVFWGQDHKV---D
FIL---------------QREPYC-RDINQLSEALLSLNF--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
--------------------------------------------------------MLL-
--SGGDPPAQEWFMVQTKS-KPRVQRQRLQVQRIFRVKLNAFQ----------SRPDTPY
FWLQLEGPRENMGKAKEYLKGLCNPELWKEVRYPPILHCAFLGAQGLF-LDCLCWSTLAY
----------L---VPGPPGSLMVGGLTESFVMTQNWLEELVGRLRWGPAPLLTPRGIWE
AEVTRAFGALVWIRGDQHAGDLLQLPPAVQELLLSLVRDAAGKEDI-IEWLSRFGISDSH
---SDP-------EVLI-------------------------------------------
-CPPQQQKEAPAMVSVGESPG---PFVDMGTLQ-----NRVPEN--SKRLSSLGATGSLI
---------PAQSTPQ----------EAANQLVRVGSNSQ---GG-MDSAQEEGP---VQ
ATSSQDSTNHTQA--------LLKQKQVQRIEDK--LLFQP--PVSALGVCPSWKAWTPG
PA--------FGPLWPGA------IAATFWRIN---ELHS----LHLAWLLSQACFNFPF
WQ-RPLGPIQLKLPGQNPLPLNLEWKQKELAPLPSAESPAGRPDGGLG---GEAALQNCP
RPEIPP-KVTSLLVVPGSSDVKDKVSSDLPQIGPPLTSTPQLQAGGESGDQGS-MQLDFK
GLEEGPAPVLPTG------------QGKPMAQGELTDQSVPGAQTVPETLKVPMAAAVPK
AENPPRTQVPPAAPKVPTSQMMPA-VHTEPAAPKVPS-----------------------
-------------APTKP------AAQLMAT-AQKTVVNQPVL----AAQVEPTTPKTPQ
AQKMPV---AKTSPAGPKTPKAQAGPAATVSKAPAASKA------------PAAPKVPVT
PKVSRAPKT--------PAAQKVPMDAGPTLDVAKLLSEVQPTSRASASLPKGQGQA-GR
QGPQPSGTVALSSKHQFQMEGLLGA-WEGAPRQPPRHLQ-----ANNTVTSFQRYHEALN
TPFELNLSGEPGNQGLRRVVIDGSSVAMVHGLQHFFSCRGIAMAVQFFWNRGHREV----
TVFVPTWQLKKNRRVRESHFLTKLHSLKMLSITPSQLENGKKITTYD-------YRFM-V
KLAEETDGIIVTNEQIHILMNNS-KKLM--VKDRL-------------------------
-LPFTFAGNL------FMVPDDPLGRDGPTLDEFLKKPNRLDTDIGNFLKV----WKTLP
PSSASVTELSDD-ADSGPLESPPNMEEVREEKEERQDE---E-----------Q------
--RQGQGT--------QKAA-EEDDLDSSLASVFRVECPSLSEEILRCLSLHDPPDGALD
IDLLPGAASPYLDIPWD--GQAPCQQVLAHLAQLTIPSNFTALSFFVGFMDSHRDAIPDY
EALVGPLHSLLKQKPDWQWDQEHEEAFLALKRALVSALCLTAPNSQLPFHLEVTVSHVAL
TAILHQEHSGRKHPIAYTSKPLLPDEESQGPQSGGDSPYAVAWALKHFSRCIGDTPVVLD
LSYASRTTVDPEVREGRRVSKAWLIRWSLLVQDKGKRALELALLQGLLGENRLLTPA-AS
MPRFFQVLPPFSDLSTFVCIHMSGYCFYREDEWCAGFGLYVLSPTSPPVSLSFSCSPYTP
TYAHLAAVACGLERFGQSPLPVVFLTHCNWIFSLLWELLPLWRARGF-LSSDGAPLPHPS
LLSYIISLTSGLSSLPFIYRTSYRGSLFAVTVDTLAKQGAQGGGQWWNLPNDVPAP-TVT
PHAMGKRPNLLALQLSDSTLADIIARLQAGQKLSGSSPFSSAFNSLSLDKESGLLMFKGD
KKPRVWVVPTQLRRDLIFSVHDIPLGAHQRPEETYKKLRLLGWWPGMQEHVRDYCRSCLF
CIPRNLIGSELKVIESPW---P--LRS--TAPWSNLQIEVVGPVTISEEGHKHVLIVADP
NTRWVEAFPLKPYTHTAVAQVLLQHVFARWGVPVRLEAAQGPQFARHVLVSCGLALGAQV
ASLSRDLQFPCLTSSGAYWEFKRALKEFIFLHGKKWAASLPLLHLAFRASSTDATPFKVL
TGGESRLTEPLWWEMSSANIEGLKMDVFLLQLIGELLELHWRVADKASEK---AENRRFK
RESQEKEWNVGDQVLLLSLPRNGSSAKWVGPFYIGDRLSLSLYRIWGFPTPEKLGCIYPS
SLMKAFAKSGTPLSFKVLEQ----

------------------------------------------------------------
--------------------------------------------------------MLL-
--SGGRPPAQEWFMVQSKS-KPRVHRQRLQVQRIFRVKVNAFQ----------SRPDNPY
FWLQLEGPRENTGKAKEYLKGLCSPELWKEVRYPPVLHCAFLGAQGLF-LDCLCWSTLAY
----------L---VPGPPGSLMVGGLTESFTMIQNWLEELVARLRWGPAPMVTPRGVWE
TEVTRAFGALVWIRGDQYAGDLLQLPPAVQELLLSLVRDAAGKEDI-VDWLSHFGISGTC
---SN--------PEVL-----I-------------------------------------
-YPTPQQKEGSSLVTIGESPG---PFLEIGTWN------QASEN--SKRSTGLGAAGSLM
---------PVQSTQQ----------ETACQLVQICSNKQ---GD-TDSAREEGAI--VQ
TLSSQDSANHTQA--------LLQQRQAQRMEDR--VSLQS--PVSALSA------WAPG
PA--------FGPLWPGT------IAATFWKIN---KLHS----LHLAWLLSQACLNFPF
WQ-RPVGPIQLKLPGQTRLPLNLGWKPKALAPLPSTENQACRPDGEPG---RETSLEHSP
KPETPT-GGTRLSVVPGDCAIEEMVSSGPPQVAPSLTSIPQ-------VGVES-ALSDGK
GLEKLSPSVLPTEQ------RGPTAHQRPVAQPAAPV--VPTAPQRALGQQAAPVVPTA-
--PQQATPVVPTAPQRALGQQAAPVVPTAPKTPAQKM-----------------------
-------------PSVKTPASP-----------------------------TPKVQTGN-
-----------ATKAGPA-----------------------------TPKTPSTTKAPAT
SKVPVV--------------------AGQTLDVAKPLSEVQASKS-RAVGPKGQGKA-GR
QGLQASSTLASRNSHPFLREGLLGA-WEGAQRQSSRHPQ-----AINTVTSFQRYHEALN
TPFELNLSGEPGNPGLRRVVIDGSSVAMVHGLQHFFSCRGIAMAVQYFWNRGHREV----
TVFVPTWQLKKHRRVRESHFLTQLHSLRMLSITPSQLENGKKITTYD-------YRFM-V
KLAEETDGIIVTNEQIHILMNNS-KKLMV-RDR---------------------------
SLF-HFTGFCGVTTHVAFPLDNLWGGDAPSP-SSACFGNRLDMDIGNFLKV----WKTLP
LSSASVSELSDD-AGPEPLVGPQSVEEVGEEREKSPEEELVE------------------
-------------GPGTPKPDEQDDHYSSLVAVFGAECPSLSEEILWCLSLHDPSEGALD
IDLLPAVSSPCL-PPWD--GKAPCQQVLAQLTQLTIPSNFTALSFFMGFMDSHRDVIPDY
EVLMGPLHGLLKQKPDWQWNQEHEKAFLALKRALVSALCLSAPNSHLPFYLEVTVSRVSL
TAILQQEHSGRKHPIAYTSKPLLPDEDSEGPQSGGDSPYAVSWALRHFSRYIGDNPVVLR
LSYASRTAVDSETRESHRASKEWLIRWSLLVQDKGKRELEFSLLQGLLGENQLLTAA-SS
MPRVFQLLPPSTDLSAFICIHVSGYCFYRDDELCAGFGLYILSPTSPPVSLAFSCPPHTP
TCAHLAAVACGLERFGQSRLPVVFLTHCNWIFSVLWELLPLWKARGF-LSSDGAPLPHPS
LLSYIMSLTSGFSSLPFIYRTSYRGSLFAVTVDNLAKQGAQGGGQWWDLPKDVPVP-VVT
PHAKGRKPDLRALQRSDSTLADIIAKLQAGQKLSGPSPFSSAFNSLSLDKDSGLLMFKGE
KHPRVWVVPRQLRRDLIFSVHDTPLGGHQGPEETYKKLRLLGWWPGMQEHVKDYCRSCLF
CIPKNLTGGELKVIESPWP-----LRS--TAPWSSLQIEVVGPVTASEEGHKYVLLVADA
NTRWVEAFPLKPYTHMAVAHVLLQHVFARWGVPIRLEAAQGPQFARHVLVSCGLALGAQV
TTLSRALQFPCLMSSEAYWEFKRALKEFIFLHGKKWAASLPLLHLAFRASTTQATPYQVL
TGGEMRLMEPLWWEVSSANIEGLKMDAFSSRLTWELLDLHWRVAEKAGEK---ADNRRLK
REVQEKDWKVGDQVLLLSLPRNGSSAKWMGPFYIGDRLSPSLYRVWGFPIPEKLGLVYPS
SLMKAFANGSTPLSLSVPLSELEL

------------------------------------------------------------
--------------------------------------------------------MSTW
-GLASS--TPDRFAVSAVA-ENKVREQQARLERIFSVGMSVLS---------KDCPENPH
IWLQLEGPKENVCRAKEYLKGLCSPELQSEIRYPPRLHCVFQGAQGFF-LDCLAWSTSAH
----------L---VPLVPGSLMISGLTEAFVMAQSRVEELVQRLSWDLQLPSYSGVSAS
AGVLRDFSALLQTRKDAYTEALLQLPLAVQEELLSLVQEASREHGLQA----LPSHE-QG
S----P-------DLLSAQF--Q----GVRAP-LNKG----GESPG------TGMVGWGE
SK------------------------------------------AAR--GES--------
----------------------------------H----SAEKEGRKQDAVRDM----HS
GQKDASGE-------------------------------------EDWERG------VAF
K-----------SQPAGG----------------------------------GA-EE---
-----VVPLKGKALGKEEVP----------------QQRGG-FSMQGE---PSGAPVPTQ
RAA-----------------------------------------QTRGASLLQRLHN--G
NTSPPRV-----------------------------------------------------
-------------PSPPSA-----------------------------------------
--------------PEPPWPCGDR------D-RGDR------------------------
------------------------------------------------------------
------GDK----------QQA---------------GARGRG----S--P---------
--------------------------WKRG------TRG-----G-NLVTGTQRFQEALQ
DPFTLCLANVPGQPDLRHIVIDGSNVAMVHGLQHYFSSRGIALAVQYFWDRGHRDI----
TVFVPQWRFSKDSKVRESHFLQKLYSLSLLSLTPSRVMDGKRISSYD-------DRFM-V
KLAEETDGIIVSNDQFRDLAEESDKWMAIIRER---------------------------
LLPFTFVGNL------FMVPDDPLGRNGPTLDEFLKKTVRK-QGSA-KTPQPSRGPTDHG
----------------------------------NQQ-----------------------
--------------QGKQGKEEERGS-GG--IRKTRETERLRRQLLEVFWGQDHKV---D
FIL---------------QREPYC-RDINQLSEALLSLNF--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
--------------------------------------------------------MLL-
--SGGKPPAQEWFMVQTKS-KPRVHRQRLQVQRIFRVKVTAFQ----------SRPDTPY
FWLQLEGPRENTGKAKEYLKGLCNPELWKEVRYPPVLHCAFLGAQGLF-LDCLCWSTLAY
----------L---VPGPPGSLMVGGLTESFTMTQNWLEELVARLRWGPAPMITPRGVWE
TEVTRAFGALVWIRCDKYAGDLLQLPPAVQELLLSLVRDAAGKEDI-IEWLGHFGISGTC
---PNP--------EIL-----I-------------------------------------
-CLARQQKESASLVTIKESPG---TLQEIGALN------RASEN--SKKTTSSGAAGSLI
---------QAQSPPA-------Q--ETADQLARDQSNKQ---GDETNSVGEEGTA--TQ
DTSSQDSENPTQA--------LLQQKQVPKNEER--ISLLL--PVSALSAYTSWKVWAPG
TA--------FGPSWPGT------IAATFWKIN---ELQS----LHLAWLLSQACLNFPF
WQ-RPTGPIQLKLPGRNPLPLKLEWKQKELAPLSSAGSPACRPGGDLG---RETALKHSP
RPEIPS-KIISLSVVPGGCGIKEKVSPGLLQVGPSSTS---------VVDKGI-TLSDCK
GLEKPFSLALSTEQ------GGSTAQERPLAQAGMTGHSVPGAPTVSETLQVATAAEVSN
VDHPPTGEGLPATPKVPTAQKKPA-VYTEPTAPKVPS-----------------------
-------------APTEPAAPA-----------------------------TPTAPQTPT
AQKTPS----VKTLAGLQ-----------------------------TPKVQSETIATAG
SVAPKAPA--------------ASAVAGPTVDVTKLLS-EVQASKSRAIMPKVQGKP-GR
QGFQPSSTVPSRSKHQFLKEGLLGA-WEGSQRLSPH-SQ-----GTNIVTSFQRYNEALN
TPFEMNLSEEPGNPGLRRVVIDGSSVAMVHGLQHFFSCRGIAMAVQYFWNRGHREI----
TVFVPTWQLKKNRRVRESHFLTKLHRLKMLSITPSQLENGKKITTYD-------YRFM-V
KLAEETDGVIVTNEQIHILMNNS-KKLMV-KDR---------------------------
LLPFTFAGSL------FMVPDDPLGRDGPTLEEFLKKPNRLDMDIGNFLKV----WKTLP
PSSASISELSDD-ADAEPLEDPQDIEE-AGKEEGSLE----E------------------
-------------EPGIPKPDEEDEQDTNPVSVFGVECPSFSEEILQCLSLHDPSEGTLD
IDLLPVVSSPYLDVPWD--GKAPCQQVLAQLAQLTIPSNFTALSFFMGFMDSHRDVISDY
EDLVGPLHGLLKQKPDWQWNQEHEKSFLALKRALVCALCLSTPNPNLPFYLEVTVSQVSL
TASLHQEHSGRKHPIAYTSKPLLPDEDSEGPQSGGDSPYAVAWALKHFARCVGDNPVVLR
LSYASRTTVDNEAWDSRRASKAWLIRWSLLLQDKGKRELELSLLQGLLGENQLLTPP-SS
MPRVFQPLPPSSDLSTFICVHVSGYCFYRDDELCAGFGLYILSPTSPPVSLAFSCSPYTT
TYAHLAAVACGLERFGQSQHPVVFLTHCNWIFSVLWELLPLWRVRGF-LSSDGASLPHPS
LLSYIISLASGFSPLPFIYRTSYRGSLFAVTVDTLAKQGAQGGGQWWDLPKDVPVP-TVT
PHPKGRKPNLLALQLSDTTLADIIAKLQAGQKLSGPSPFSSAFNSLSLDQDSGLLMFKGE
RHPRVWVVPRQLRRDLIFSVHDSPIGEHQGLEDTYKTVRLLGWWPGMQDHVRDYCRSCLF
CIPRNLVGGELKVIESPWP-----LRS--TAPWSSLQIEVVGPVTVSEEGHKHVLIVADA
NTRWVEAFPLKPYTHVAVAQVLLQHVFARWGVPIRLEAAQGPQFARHVLVSCGLALGAQV
TTLSRALQFPCLMSSEAYWEFKRALKEFIFLYGKKWAASLPLLHLAFRASTTEATPFQVL
TGGEMKLMEPVWWEMSRANIEGLKMDAFLLQLMRELLDLHWRVAEKASEK---AENRRFK
RESQENEWSVGDQVLLLSLPRNGSSAKWMGPFYIGDRLSLSLYRVWGFPVPDKLGCVYPS
SLMKAFPKHDTPLSLDVEQ-----

------------------------------------------------------------
--------------------------------------------------------MSGW
-QSAFP--IPDRFAVSAEA-ESKVREQQARLERIFSVRMCVLP---------KDCPENPH
IWLQLEGPKENVRRAKEYLKGLCSPELQSEIHYPSRLHCIFVGAKSFF-LDCLAWSTSAH
----------L---VPLVPGSLMISGLTEAFVMAQSRVEDLVQRLSWDLQLQPCPGAPES
ARVLRDFTALIQPLEDPYEEALLQLSLAVQEELLSLVQEASRGQGPKV----LSYRE-GK
I----I-------GLLGAQF--Q----GARAH-LNEG----GESLG------TGTAGQGE
SK------------------------------------------AAR--GES--------
----------------------------------H----TVEKEGGKQDGPKEM----DS
GWKESPGE-------------------------------------EASKTA------VTF
K-----------SQPAGG----------------------------------G--AE---
-----MGSLKGKALGRQQVP----------------QQKVG-FTVQGE---PPSAHVPCQ
RAA-----------------------------------------QPRGASLLQRLHN--G
KASPPRV-----------------------------------------------------
-------------PSPPPA-----------------------------------------
--------------PEPPWPCGDRGDR--GD-RGD-------------------------
------------------------------------------------------------
--------K----------QQT---------------VTRGRG----S--P---------
--------------------------RKRG------TRG-----G-NLVTGTQRFQEALQ
DPFTLCLANVPGQPDLRHIVIDGSNVAMVHGLQHYFSSRGIAIAVQYFWDRGHRDI----
TVFVPQWRFSKDSKVRESHFLQKLYSLSLLSLTPSRVMDGKRISSYD-------DRFM-V
KLAEETDGIIVSNDQFRDLAEESDKWMAIIRER---------------------------
LLPFTFVGNL------FMVPDDPLGRKGPTLDEFLKKPAGD-QGSA-KTQRPSRGFAEHG
----------------------------------SQQ-----------------------
--------------PGKE----EERGGGG--LRKTRETERLRRQLLEVFWGQDHKV---D
FIL---------------QREPYC-RDINQLSEALLSLNF--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
--------------------------------------------------------MPTW
-EARPA--SPDRFAVSAEA-ENKVREQQPHVERIFSVGVSVLP---------KDCPDNPH
IWLQLEGPKENASRAKEYLKGLCSPELQDEIHYPPKLHCIFLGAQGFF-LDCLAWSTSAH
----------L---VPRAPGTLMISGLTEAFVMAQSRVEELTERLSWDFTPGPSSGASQC
TGVLRDFSALLQSPGDAHREALLQLPLAVQEELLSLVQEASSGQGPGA----LASWE-GR
S----S-------GLLRAQC--Q----EERAP-PSDG----RESLD------TGSVGPRD
SR------------------------------------------GAR--GDN--------
----------------------------------Y----AVEKEGGKQGGPREM----DL
GWKELPGE-------------------------------------EAWERE------VAL
R-----------PQSVGG----------------------------------GL-RES--
-----APL-KGKALGKEEVT----------------QGGGG-VCVHRE---PPGAHGSCH
RAA-----------------------------------------QSRGASLLQRLHN--G
NASPPRV-----------------------------------------------------
-------------PSPPPA-----------------------------------------
--------------PEPPWHCGDRGDWGDRGDGGDR------------------------
------------------------------------------------------------
------GDK----------QQG---------------VARGRG----P--Q---------
--------------------------WKRG------ARG-----G-NLVTGTQRFKEALQ
DPFTLCLANVPGQPDLRHIVIDGSNVAMVHGLQHYFSSRGIAIAVQYFWDRGHRDI----
TVFVPQWRFSKDSKVRESHFLQKLYSLSLLSLTPSRVMDGKRISSYD-------DRFM-V
KLAEETDGIIVSNDQFRDLAEESEKWMAIIRER---------------------------
LLPFTFVGNL------FMVPDDPLGRNGPTLDEFLKKPART-QGSS-KAQHPSRGFAEHG
----------------------------------KQQ-----------------------
---------------H--G-REEEKGSGG--IRKTRETERLRRQLLEVFWGQDHKV---D
FIL---------------QREPYC-RDINQLSEALLSLNF--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
--------------------------------------------------------MLL-
--SGGDPPAQEWFMVQTKS-KPRVQRQRLQVQRIFRVKLNAFQ----------SRPDTPY
FWLQLEGPRENMGKAKEYLKGLCSPELWKEVRYPPILHCAFLGAQGLF-LDCLCWSTLAY
----------L---VPGPPGSLMVGGLTESFIMTQNWLEELVGRLRWGPAPLLTPRGIWE
AEVTRAFGALVWIRGDQHAGDLLQLPPAVQELLLSLVRDAAGKEDI-IEWLSRFGISDSH
---SDP-------EVLI-------------------------------------------
-CPPQQQKEAPAMVSVGESPG---PFVDMGTLQ-----NRGPEN--SKRLSSLGATGSLI
---------PAQSTPQ----------EAANQLVRVGSNNQ---DG-MDSAQEEGS---VQ
ATSSQDSTNHTQA--------LLKQRQVQKIEDK--LLFQP--PVSALGVCPPWKAWTPG
PA--------FGPLWPGA------IAATFWRIN---ELHS----LHLAWLLSQACFNFPF
WQ-RPLGPIQLKLPGQNPLPLNLEWKQKELAPLPSAESPAGRPDGGLG---GGAALQNCP
RPEISP-KVTSLLVVPGSSDVKDKVSLDLPQIGPPLTSTPQLQAGSEPGDQGS-MQLDFK
GLEEGPTPVLPTG------------QGKPVAQGGLTDQSVPGAQTVPETLKVPMSAAVPK
AENPPRTQVPSAAPKVPTSRMMLA-VHTEPAAPEVPL-----------------------
-------------APTKP------TAQLMAT-AQKTVVNQPVL----VAQVEPTTPKTPQ
AQKMPV---AKTSPAGPKTPKAQVGPAATVSKAPAASKA------------PAAPKVPVT
PRVSRAPKT--------PAAQKVPTDAGPTLDVARLLSEVQPTSRASVSLLKGQGQA-GR
QGPQSSGTLALSSKHQFQMEGLLGA-WEGAPRQPPRHLQ-----ANSTVTSFQRYHEALN
TPFELNLSGEPGNQGLRRVVIDGSSVAMVHGLQHFFSCRGIAMAVQFFWNRGHREV----
TVFVPTWQLKKNRRVRESHFLTKLHSLKMLSITPSQLENGKKITTYD-------YRFM-V
KLAEETDGIIVTNEQIHILMNNS-KKLM--VKDRL-------------------------
-LPFTFAGNL------FMVPDDPLGRDGPTLDEFLKKPNRLDTDIGNFLKV----WKTLP
PSSASVTELSDD-ADSGPLESLPNMEEVREEKEERQDE---E-----------Q------
--RQGQGT--------QKAA-EEDDLDSSLASVFRVECPSLSEEILRCLSLHDPPDGALD
IDLLPGAASPYLGIPWD--GKAPCQQVLAHLAQLTIPSNFTALSFFMGFMDSHRDAIPDY
EALVGPLHSLLKQKPDWQWDQEHEEAFLALKRALVSALCLMAPNSQLPFRLEVTVSHVAL
TAILHQEHSGRKHPIAYTSKPLLPDEESQGPQSGGDSPYAVAWALKHFSRCIGDTPVVLD
LSYASRTTADPEVQEGRRVSKAWLIRWSLLVQDKGKRALELALLQGLLGENRLLTPA-AS
MPRFFQVLPPFSDLSTFVCIHMSGYCFYREDEWCAGFGLYVLSPTSPPVSLSFSCSPYTP
TYAHLAAVACGLERFGQSPLPVVFLTHCNWIFSLLWELLPLWRARGF-LSSDGAPLPHPS
LLSYIISLTSGLSSLPFIYRTSYRGSLFAVTVDTLAKQGAQGGGQWWSLPKDVPAP-TVS
PHAMGKRPNLLALQLSDSTLADIIARLQAGQKLSGSSPFSSAFNSLSLDKESGLLMFKGD
KKPRVWVVPTQLRRDLIFSVHDIPLGAHQRPEETYKKLRLLGWWPGMQEHVKDYCRSCLF
CIPRNLIGSELKVIESPW---P--LRS--TAPWSNLQIEVVGPVTISEEGHKHVLIVADP
NTRWVEAFPLKPYTHTAVAQVLLQHVFARWGVPVRLEAAQGPQFARHVLVSCGLALGAQV
ASLSRDLQFPCLTSSGAYWEFKRALKEFIFLHGKKWAASLPLLHLAFRASSTDATPFKVL
TGGESRLTEPLWWEISSANIEGLKMDVFLLQLVGELLELHWRVADKVSEK---AENRRFK
RESQEKEWNVGDQVLLLSLPRNGSSAKWVGPFYIGDRLSLSLYRIWGFPTPEKLGCIYPS
SLMKAFAKSGTPLSFKVLEQ----

------------------------------------------------------------
--------------------------------------------------------MLL-
--SGGRPPAQEWFMVQSKS-KPRVHRQRLQVQRIFRVKVNAFQ----------SRPDTPY
FWLQLEGPRENTGKAKEYLKGLCSPELWKEVRYPPVLHCAFLGAQGLF-LDCLCWSTLAY
----------L---VPGPPGSLMVGGLTESFTMTQNWLEELVARFRWGPAPMITPRGGWE
TEVTRAFGALVWIRGDQYAGDLMQLPPAVQELLLNLVRDAAGKEDL-VEWLSHVGSSSTC
---AS--------PEVL-----I-------------------------------------
-CPGQQQKEGSSLVTVGESPG---PFLEIGALN------QASEN--SKKLARLGATGSPT
---------PAQSSQQ----------ESACQLVRIRPSKQ---GE-VTSAREEGPL--VP
TASSQGSANHTQA--------LLQQRQAQRTEDR--ISLRS--PVSALSVCPSWKSWAPG
PA--------FGPLWPGA------IAATFWKIN---ELHS----LHLAWLLSQACFSFPF
WQ-RPMGPIQLKLPGQNPLPLNLEWKPKELTPLPRAENQACRPDGELG---RETALQHSP
RPETPS-EVISLSGVPGDCGIIEVPS---------LTSAPQAEA--EQEDERS-SLSDGD
GLKK-SSSALPTEQ------RGPTAQERTVAQ------SVPKAPAMSETPEAPAATAVFK
VHHPPTEEGLPPASKVPPALKPA--VDTEPAAPKNMP-----------------------
-------------SVKTPAVPQ-----------------------------TPKVQTGN-
-----------ATKAGSA-----------------------------TPQTPSTTKTPAA
SKASRE-------------STV----AGLSLDEAKLLNEVQASKG-RAVVPKGQGKT-GR
QGLQASNNLASRNKHQFLKEGLLGA-WDGAQRKSAHHPQ-----ANNTVTSFQRYHEALN
TPFELNLSGEPGNPGLRRVVIDGSSVAM-----HFFSCRGIAMAVQYFWNRGHREV----
TVFVPTWQLKKNRRVRGEVLSP-LASL------PHSPTVG--NFLCP-------CRFM-I
KLAEETDGVIVTNEQIHILMNNS-KKLMV-KDR---------------------------
LLPFTFAGNL------FMVPDDPLGRDGPTLDEFLKKPNRLDMDIGNFLKV----WKTLP
PSSASISELSDE-ADPEPVVGPQNVEEVREKREDSPL-----------------------
---------------EIPKPGEQDDRDSSLASVFGAECPSFSEEILWCLSLHDPSEGALD
IDLLPVVSSPYTDVPWD--GQAPCQQVLAQLAQLTIPSNFTALSFFVGFMDSHRDAIPDY
EVLVGPLHSLLKQKPDWQWNQEHKKAFLALKRALVSALCLSTPNSDLPFYLEVTVSQVSL
MAILQQEHSGRKHPIAYTSKPLLPDEDSEGPQSGGDRPYAVAWALKHFSRCIGDNPVVLC
LSYASRTTVDSETWESCRVSKAWLIRWSLLVQDKGKRDLELTLLHGLLGENRLLTPA-SS
MPRVFQLLPPSTDLSTFICIHISGYCFYRDDELCAGFGLYILSPTSPPVSLTFSCFPYTL
TYAHLAAVACGLERFGQSHLPVVFLTHCNWIFSVLWELLPLWKARGF-LSSDGASLPYPS
LLSYIISLTSGFSSLPFIYRTSYRGSLFAVTVDTLAKQGAQGGGQWWDLPEDVPVP-IVT
PHTKGRKPNLLALQLSDGTVAEIIAKLQAGKKLSGPSPFSSAFNSLSLDKDSGLLMFKGE
KHPRVWVVPRQLRRDLIFFVHDIPLGGHQRPEETYKKLRLLGWWPGMQEHVKDYCRSCLF
CIPQNLVGGELKVIESPWP-----VRS--TAPWSSLQIEVVGPVTASEEGHKHVLIVADA
NTRWVEAFPLKPYTHMAVAQLLLQHVFARWGVPIRLEAAQGPQFARHVLVSCGLALGAQV
TTLSRTLQFPCLMSSEAYWEFKRALKEFIFLHGKKWAVSLPLLHLAFRASNPEATPYQVL
TGDEMRLMEPLWWEMSSANIEGLKMDTFLLRLARELLDFHWRVAEKAGEK---ADNRRFQ
REIQNKGWNVGDQVLLLSLPRNGSGAKWVGPFYIGDRLSLSLYRVWGFPTPEKLGCVYPS
SLMKAFANGGAALSLNDLDQ----

------------------------------------------------------------
--------------------------------------------------------MPTW
-EARPA--SPDRFAVSAEA-ENKVREQQPHVKRIFSVGVSVLP---------KDCPDNPH
IWLQLEGPKENASRAKEYLKGLCSPELQDEIHYPPKLHCIFLGAQGFF-LDCLAWSTSAH
----------L---VPRAPGSLMISGLTEAFVMAQSRVEELTERLNWDFMPGPSSGASQC
TGVLRDFSALLQSPGDAHREALLQLPLAVQEELLSLVQEASSGQGPGA----LASWE-GR
S----S-------GLLGAQC--Q----EERAP-PSDG----RESLD------TGSVGPRD
SR------------------------------------------GAR--GDN--------
----------------------------------Y----AVGKEGGKQGGPREM----DL
GWKELPGE-------------------------------------EAWERE------VAL
R-----------PQSVGG----------------------------------GL-RES--
-----ALL-KGKALGKEEVT----------------QGGGG-LCVHRE---PPGAHGSCH
RAA-----------------------------------------QSRGASLLQRLHN--G
NASPPRV-----------------------------------------------------
-------------PSPPPA-----------------------------------------
--------------PEPPWHCGDRGDWGDRGDGGDR------------------------
------------------------------------------------------------
------GDK----------QQG---------------MARGRG----P--Q---------
--------------------------WKRG------ARG-----G-NLVTGTQRFKEALQ
DPFTLCLANVPGQPDLRHIVIDGSNVAMVHGLQHYFSSRGIAIAVQYFWDRGHRDI----
TVFVPQWRFSKDSKVRESHFLQKLYSLSLLSLTPSRVMDGKRISSYD-------DRFM-V
KLAEETDGIIVSNDQFRDLAEESEKWMAIIRER---------------------------
LLPFTFVGNL------FMVPDDPLGRNGPTLDEFLKKPART-QGSS-KAQHPSRSFAEHG
----------------------------------KQQ-----------------------
---------------H--G-REEEKGSGG--IRKTRETERLRRQLLEVFWGQDHKV---D
FIL---------------QREPYC-RDINQLSEALLSLNF--------------------
------------------------------------------------------------
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------------------------

------------------------------------------------------------
--------------------------------------------------------MSTW
-GFASP--TPDRFAVSAVA-EDKVREQQARVERIFSVGMSVLS---------RDCPENPH
IWLQLEGPKENVCRAKEYLKGLCSPELQSEICFPPRLHCVFQGAQGLF-LDCLSWSTSAH
----------L---VPLAPGSLMISGLTEAFVMAQSRVEELMQRLSWDLQLPSCPGASAS
AGVLRDFSALLQTRVDAYTEALLQLPLAVQEELLSLVQEASREQGPQA----LPSR--EH
S----P-------GLLSAQF--Q----GVRAP-LNEG----GESPG------TGVAGWGE
SR------------------------------------------AGR--GES--------
----------------------------------H----TVEKRGRKQDGVRNM----YP
ARKEPPGE-------------------------------------HVWERG------VAF
K-----------SQPAGA----------------------------------GA-EEA--
-----AAPLKGKASGKEEGP----------------QQRGG-FPMQDE---PSGAHVPPQ
RAA-----------------------------------------PTRGASLLQRLHN--G
NTSPPRV-----------------------------------------------------
-------------PSPPPA-----------------------------------------
--------------PEPPWPCGDR------D-RGDR------------------------
------------------------------------------------------------
------GDK----------QQA---------------GARSRG----S--P---------
--------------------------WKRG------TRG-----G-NLVTGTQRFQEALQ
DPFTLCLANVPGQPDLRHIVIDGSNVAMVHGLQHYFSSRGIALAVQYFWDRGHRDI----
TVFVPQWRFSKDSKVRESHFLQKLYSLSLLSLTPSRVMDGKRISSYD-------DRFM-V
KLAEETDGIIVSNDQFRDLAEESDKWMAIIRER---------------------------
LLPFTFVGNL------FMVPDDPLGRNGPTLDEFLKKTDRK-QGSS-KAHQPPRGPPEHG
----------------------------------NQQ-----------------------
--------------QGKQGKEEETGSGGG--IRKTRETERLRRQLLEVFWGQDHKV---D
FIL---------------QREPYC-RDINQLSEALLSLNF--------------------
------------------------------------------------------------
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------------------------

------------------------------------------------------------
--------------------------------------------------------MPTW
-EARPA--SPDRFAVSAEA-ETKIREQQPHVERIFSVGVSVLP---------KDCPDNPH
IWLQLEGPKENTSRAKEYLKGLCSPELQDEIHYPPKLHCIFLGVQGFF-LDCLTWSTSAH
----------L---VPREPGSLMISGLTEAFVMAQSRVEELVERLSWDFLPGPSPGASQC
PGVLRDFSALLHSPGDAHREALLQLPLAVQEELLSLVQEASSGQGPGA----LASWE-GR
S----S-------GLLGAQC--Q----GVRAP-PSDG----RESVD------TGSVGPRE
SR------------------------------------------GAR--GDS--------
----------------------------------Y----AVE-KEGKQGGPREM----AF
GWKELPGE-------------------------------------EAWERE------VGL
R-----------PQSVGR----------------------------------GA-RES--
-----APL-KGKTLGKEEAT----------------QGGGG-VCVHRE---LPSAHGSCH
RAA-----------------------------------------QSRGASLLQRLHN--G
NASPPRV-----------------------------------------------------
-------------PSPPPA-----------------------------------------
--------------PEPPWHCGDRGDWGD---GGDR------------------------
------------------------------------------------------------
------GDK----------QQA---------------TARGRG----P--H---------
--------------------------WKRG------ARG-----G-NLVTGTQRFKEALQ
DPFTLCLANVPGQPDLRHIVIDGSNVAMVHGLQHYFSSRGIAIAVQYFWDRGHRDI----
TVFVPQWRFSKDAKVRESHFLQKLHSLSLLSLTPSRVMDGKRISSYD-------DRFM-V
RLAEEKDGIIVSNDQFRDLAEESENWMAIIRER---------------------------
LLPFTFVGNL------FMVPDDPLGRNGPTLDEFLKKPART-QGPS-KAQHPSRGFAEHG
----------------------------------KQQ-----------------------
---------------Q--G-REEEKGSGG--IRKTRETERLRRQLLEVFWGQDHKV---D
FIL---------------QREPYC-RDINQLSEALLSLNF--------------------
------------------------------------------------------------
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------------------------

------------------------------------------------------------
--------------------------------------------------------MSTW
-GLASP--TPDRFAVSAVA-EDKVREQQARLERIFSVGMSILS---------KDCPENPH
IWLQLEGPKENVCRAKEYLKGLCSPELQSEICYPPRLHCVFRGAHGFF-LDCLAWSTSAH
----------L---VPLVPGSLMISGLTEAFVMAQSRVEELVQRLSWDLQLQSCPGAPAS
AGVLRDFSALLQTREDAYMEALLQLPLAVQEELLSLAQEASGEQGPQV----LPSPERQG
S----G-------GLLSAQF--Q----GVRAP-LSQG----GESQG------TGVVGSGD
SR------------------------------------------AAR--GER--------
----------------------------------P----TMEKQGSKQDGVRDT----HS
GRKEPSGE-------------------------------------EIWERG------VAF
K-----------SQPVGG----------------------------------GA-E----
------APLKGKALGKEEVP----------------QQRGG-FSMQGD---SSGAHVPSQ
RAA-----------------------------------------QTRGASLLQRLHN--G
STSPPRV-----------------------------------------------------
-------------PSPPPA-----------------------------------------
--------------PEPPWPCGDR------D-RGDR------------------------
------------------------------------------------------------
------GDK----------QQA---------------GARGRG----S------------
---------------------------KRG------ARG-----G-NLVTGTQRFQEALQ
DPFTLCLANVPGQPDLRHIVIDGSNVAMVHGLQHYFSSRGIALAVQYFWDRGHRDI----
TVFVPQWRFSKDSKVRESHFLQKLYSLSLLSLTPSRVMDGKRISSYD-------DRFM-V
KLAEETDGIIVSNDQFRDLAEESDKWMAIIRER---------------------------
LLPFTFVGNL------FMVPDDPLGRNGPTLDEFLKKTVRK-QGSS-KAQQPSRGPKDHG
----------------------------------NQQ-----------------------
--------------QAKQGKEEEK---GG--IRKTRETERLRRQLLEVFWGQDHKV---D
FIL---------------QREPYC-RDINQLSEALLSLNF--------------------
------------------------------------------------------------
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------------------------

------------------------------------------------------------
--------------------------------------------------------MLL-
--SGGDPPAQEWFMVQTKS-KPRVQRQRLQVQRIFRVKLNAFQ----------SRPDTPY
FWLQLEGPRENMGKAKEYLKGLCNPELWKEVRYPPILHCAFLGAQGLF-LDCLCWSTLAY
----------L---VPGPPGSLMVGGLTESFIMTQNWLEELVGRLRWGPAPLLTPRGIWE
AEVTRAFGALVWIRGDQHAGDLLQLPPAVQELLLSLVRDAAGKEDI-IEWLSRFGISDSH
---SDP-------EVLI-------------------------------------------
-CPSQQQKEAPAMVSVGESPG---PFVDMGTLQ-----NRVPEN--SKRLSSLGATGSLI
---------PAQSTPQ----------EAANQLVRVGSNSQ---GG-MDSAQEEGP---VQ
ATSSQDSTNHTQA--------LLKQKQVQRIEDK--LLFQP--PVSALGVCPSWKAWTPG
PA--------FGPLWPGA------IAATFWRIN---ELHS----LHLAWLLSQACFNFPF
WQ-RPLGPIQLKLPGQNPLPLNLEWKQKELAPLPSAESPAGRPDGGLG---GEAALQNCP
RPEIPP-KVTSLLVVPGSSDVKDKVSSDLPQIGPPLTSTPQLQAGGESGDQGS-MQLDCK
GLEEGPAPVLPAG------------QGKPMAQGELTDQSVPGAQTVPETLKVPMAAAVPK
AENPPRTQVPPAAPKVPTSQVMPA-VHTEPAAPKVPS-----------------------
-------------APTKP------AAQMMAT-AQKTVVNQPVL----AAQVEPTTPKTPQ
AQKMPV---AKTSPAGPKTPKAQAGAAATVSKA------------------PAAPKVPVT
PKVSRAPKT--------PAAQKVPMDAGPTLDVAKLLSEVQPTSRASASLLKGQGQA-GR
QGPQPSGTLALSSKHQFQMEGLLGA-WEGAPRQPPHHLQ-----TNNTVTSFQRYHEALN
TPFELNLSGEPGNQGLRRVVIDGSSVAMVHGLQHFFSCRGIAMAVQFFWNRGHREV----
TVFVPTWQLKKNRRVRESHFLTKLHSLKMLSITPSQLENGKKITTYD-------YRFM-V
KLAEETDGIIVTNEQIHILMNNS-KKLM--VKDRL-------------------------
-LPFTFAGNL------FMVPDDPLGRDGPTLDEFLKKPNRLDTDIGNFLKV----WKTLP
PSSASVTELSDD-ADSGPLESPPNMEEDREEKEERQDE---E-----------Q------
--RQGQGM--------QKAA-EEDDLDSSLASVFRVECPSLSEEILRCLSLHDPPDGALD
IDLLPGAASPYLGIPWD--GQAPCQQVLAHLAQLTIPSNFTALSFFVGFMDSHRDAIPDY
EALVGPLHSLLKQKPDWQWDQEHEEAFLALKRALVSALCLTAPNSQLPFRLEVTVSHVAL
TAILHQEHSGRKHPIAYTSKPLLPDEESQGPQSGGDSPYAVAWALKHFSRCIGDTPVVLD
LSYASRTMVDPEVREGRRFSKAWLIRWSLLVQDKGKRALELALLQGLLGENRLLTPA-AS
MPRFFQVLPPFSDLSTFVCIHMSGYCFYREDEWCAGFGLYVLSPTSPPVSLSFSCSPYTP
TYAHLAAVACGLERFGQSPLPVVFLTHCNWIFSLLWELLPLWRARGF-LSSDGAPLPHPS
LLSYIISLTSGLSSLPFIYRTSYRGSLFAVTVDTLAKQGAQGGGQWWSLPKDVPAP-TVT
PHAMGKRPNLLALQLSDSTLADIIARLQAGQKLSGSSPFSSAFNSLSLDKESGLLMFKGD
KKPRVWVVPTQLRRDLIFSVHDIPLGAHQRPEETYKKLRLLGWWPGMQEHVRDYCRSCLF
CIPRNLIGSELKVIESPW---P--LRS--TAPWSNLQIEVVGPVTISEEGHKHVLIVADP
NTRWVEAFPLKPYTHTAVAQVLLQHVFARWGVPVRLEAAQGPQFARHVLVSCGLALGAQV
ASLSRDLQFPCLTSSGAYWEFKRALKEFIFLHGKKWAASLPLLHLAFRASSTDATPFKVL
TGGESRLTEPLWWEMSSANIEGLKMDVFLLQLIGELLELHWRVADKASEK---AENRRFK
RESQEKEWNVGDQVLLLSLPRNGSSAKWVGPFYIGDRLSLSLYRIWGFPTPEKLGCIYPS
SLMKAFAKSGTPLSFKVLEQ----

------------------------------------------------------------
--------------------------------------------------------MLL-
--SGGDPPAQEWFMVQTKS-KPRVQRQRLQVQRIFRVKLNAFQ----------SRPDTPY
FWLQLEGPRENMGKAKEYLKGLCSPELWKEVRYPPILHCAFLGAQGLF-LDCLCWSTLAY
----------L---VPGPPGSLMVGGLTESFIMTQNWLEELVGRLRWGPAPLLTPRGIWE
AEVTRAFGALVWIRGDQHAGDLLQLPPAVQELLLSLVRDAAGKEDI-IEWLSRFGISDSH
---SDP-------EVLI-------------------------------------------
-CPPQQQKETPAMVSVGESPG---TFLDMGTLQ-----NRGPEN--SKRLSSLGATGSLI
---------PAQSTPQ----------ETANQLIRVISNNQ---GG-TDSAREEGP---VQ
ATSSQDSTNYTQA--------LLQQRQVQRVEDK--LLFQP--PVSALGVCPPWKAWTPG
TA--------FGPLWPGA------IAATFWRIN---ELHS----LHLAWLLSQACFNFPF
WQ-RPLGPIQLKLPGQNPLPLNLEWKQKELAPLPSAESPAGRPDGGLG---GEAVLQNCP
RPETPP-KVMSLLVVPGSSDVNDKVSSDLPQIGPPLTSTPQLQAGGELGDQGS-TQSDCK
GLEEGPAAVLPAG------------KGKPMAQGGLTDHSVPGTQTVPETLKVPLAAAVPK
AEDPPRTQVPPAAPKVPTSQMMLA-VHTEPAAPKVPL-----------------------
-------------APTKP------AAQLMAT-AQKTVVNQPVL----AAQVEPTTPKTPQ
DQKMSKTSPVKTSPAGPKTPKAQTGPAATASKAPAAPKTTAAPKTPAAPQTPATPKVPVA
PKVSKAHKT--------LAAQKVPTDAGPTLDVAKLLSEVQPTSRASASLPKGQGQA-GR
QGPQPSGTLAVSSKHQFQMEGLLGA-WEGAPRQPPRHLQ-----ANSTVTSFQRYHEALN
TPFELNLSGEPGNQGLRRVVIDGSSVAMVHGLQHFFSCRGIAMAVQFFWNRGHREV----
TVFVPTWQLKKNRRVRESHFLTKLHSLKMLSITPSQLENGKKITTYD-------YRFM-V
KLAEETDGIIVTNEQIHILMNNS-KKLMV-K-DR--------------------------
LLPFTFAGNL------FMVPDDPLGRDGPTLDEFLKKPNRLDTDIGNFLKV----WKTLP
PSSASVTELSDD-TDSGPLESLPNVEEVREEKEERQDE---E-----------Q------
--RQGQGT--------QKLA-EEDDLDSSLASVFRVECPSLSEEILRCLSLHDPPDGALD
IDLLPGAASPYLGIPWD--GKAPCQQVLAHLAQLTIPSNFTALSFFVGFMDSHRDAIPDY
EALVGPLHSLLKQKPDWQWHQEHEEAFLALKRALVSALCLTVPNSQLPFRLEVTVSHVAL
TAILHQEHSGRKHPIAYTSKPLLPDEESQGPQSGGDSPYAVAWALKHFSRCIGDTPVVLD
LSYASRTTADPEVRDSRRVSKAWLIRWSLLVQDKGKRALELSLLQGLLGENRLLTPA-AS
MPRFFQVLPPFSDLSTFVCIHMSGYCFYREDEWCAGFGLYVLSPTSPPVSLSFSCSPYTP
TYAHLAAVACGLERFGQSPLPVVFLTHCNWIFSLLWELLPLWKARGF-LSSDGAPLPHPS
LLSYIISLTSGLSSLPFIYRTSYRGSLFAVTVDTLAKQGAQGGGQWWSLPKDVPVP-VVT
PHAMGKRPNLLALQLSDSTLADIIARLQAGQKLSGSSPFSSAFNSLSLDKESGLLMFKGD
KKPKVWVVPTQLRRDLIFSVHDIPLGAHQRPEETYKKLRLLGWWPGMQEHVRDYCRSCLF
CIPRNLIGSELKVIESPW---P--LRS--TAPWSNLQIEVVGPVTISEEGHKHVLIVADP
NTRWVEAFPLKPYTHTAVAQVLLQHVFARWGVPVRLEAAQGPQFARHVLVSCGLALGAQV
ASLSRDLQFPCLTSSGAYWEFKRALKEFIFLHGKKWAASLPLMHLAFRASSTDATPFKVL
TGGEARLTEPLWWEMSSANIEGLKMDVFLLQLVGELLELHWRVADKASEK---AENRRFK
RESQEKEWNVGDQVLLLSLPRNGSSAKWVGPFYIGDRLSLSLYRIWGFPTPEKLGCIYPS
SLMKTFAKSGTPLSFKVLEQ----

------------------------------------------------------------
--------------------------------------------------------MPTW
-GARPA--SPDRFAVSAEA-ENKVREQQPHVERIFSVGVSVLP---------KDCPDNPH
IWLQLEGPKENASRAKEYLKGLCSPELQDEIHYPPKLHCIFLGAQGFF-LDCLAWSTSAH
----------L---VPGAPGSLMISGLTEAFVMAQSRVEELAERLSWDFTPGPSSGASQC
TGVLRDFSALLQSPGDAHREALLQLPLAVQEELLSLVQEASSGQGPGA----LASWE-GR
S----S-------GLLGAQC--Q----GVRAP-PSDG----RESLD------TGSMGPGD
SR------------------------------------------GAR--GDT--------
----------------------------------Y----AVEKEGGKQGGPREV----DL
GWKELPGE-------------------------------------EAWERE------VAL
R-----------PQSVGG----------------------------------GA-RES--
-----APL-KGKALGKEEIT----------------LGGGG-FYVHRE---PPGAHGSCH
RAA-----------------------------------------QSRGASLLQRLHN--G
NASPPRV-----------------------------------------------------
-------------PSPPPA-----------------------------------------
--------------PEPPWHCGDRGDCGDRGDVGDR------------------------
------------------------------------------------------------
------GDK----------QQG---------------MARGRG----P--Q---------
--------------------------WKRG------ARG-----G-NLVTGTQRFKEALQ
DPFTLCLANVPGQPDLRHIVIDGSNVAMVHGLQHYFSSRGIAIAVQYFWDRGHRDI----
TVFVPQWRFSKDAKVRESHFLQKLYSLSLLSLTPSRVMDGKRISSYD-------DRFM-V
KLAEETDGIIVSNDQFRDLAEESEKWMAIIRER---------------------------
LLPFTFVGNL------FMVPDDPLGRNGPTLDEFLKKPART-QGSS-KAQHPSRGFAEHG
----------------------------------KQQ-----------------------
---------------Q--G-REEEKGSGG--IRKTRETERLRRQLLEVFWGQDHKV---D
FIL---------------QREPYC-RDINQLSEALLSLNF--------------------
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------------------------

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---------------QEYLKGLCNPELWKEVRYPAALHCAFLGAQGLF-LDCLCWSTLAY
----------L---VPGPPGSLMVGGLTESFVMTQNWLEELVGRLRWGPAPLLTPRGIWE
AEVTRAFGALVWIRGDQYAGDLLQLPPAVQELLLSLVRDAAGKEDI-IQWLSRIGTSDSR
---SDS-------ELLI-------------------------------------------
-CPTHQQKEGPTMVAVGDGPG---PFVEMG----------SPEN--SKRLTSLGATGALI
SGT------PGLSTQQ----------ETANQLVRVTSNNQ---GG-VDCAREEGS---VQ
ASSSQDSVDHTQA--------SSQQRQVRRGEDK--LPLQP--PVSALSVCSPWKAWTPG
PT--------FAPMWPGA------IAATFWRIN---ELHS----LHLAWLLSQACFSFPF
WQ-RPLGPIQFKLPGQNPLPLNLGWKQKELVPLPSVESPDCTPDGGPG---GEAALQNCP
RPETPK-KVMSLLVVSGGSGVKDKSIPGLPQIGPPLTSTPQLQARSELGDQGS-VQWDCK
GPEEGPVPAPPTGQGVPAAQGGLT------------APSGPDSKTVPETLKVPMAAAVPT
AQTPPTNPVLPAAPKVPETQMMVA-AHEERAASEVPS-----------------------
-------------VPTKPE------AQVVPT-AQKAAVGEPAP----------AAPHTPT
AQKRQA---AKTSPAGPQTSRAQTGPAPKTG--------------------PTAPKVPAA
PQTSRTPKT--------PAAQKAPAGPGSTLDASKLLSESQPPSRGSASFLKGQGQP-GS
QGLQCSGTLAPSSKRQPQVEGLLGA-GEGTPRQPTRHPQ-----ASNTVTSFQRYHEALN
TPFELDLSEEPGNPELRRVVIDGSSVAMVHGLQHFFSCRGIAMAVQYFWNRGHREV----
TVFIPTWQLKKNRRVRESHFLTKLHSLKMLSITPSQLENGKKITTYD-------YRFM-V
KLAEETDGIIVTNEQLHVLMNNS-KKLMV-KDR---------------------------
LLPFTFAGNL------FMVPDDPLGRDGPTLDEFLKKPNRLDTDIGNFLKV----WKTLP
PSSASISELRDD-TDPGPPESLQNVEEIREEQEEEER---------QDE---EQ------
--REEQEMQ---KP----AEEEEEDLDSSLMSVFKAECPSLSEEILRCLSLHDPQDEALD
IDLQPAVASPSLGIPWD--GKAPCQQVLAQLAQLTIPSNFTALSFFMGFTDSHRDVIPDY
EALVAPLHSLLKQKPDWRWELDHEKAFLALKRALVSALCLSVPNPQLPFHLEVTVSQVAL
TAVVYQEHSGRKHPVAYTSKPLLPDEDSEGPQSGGDSPYAVAWALKHFSRYIGDTPVVLD
LFYASRTSVDPEAWDGRRVAKAWLIRWALLVQDKGKRALELTLLQGLLGKNRLLTPT-AS
MPRFFQVLPPFSDLSTFVCIHMSGYCFYREDEWCAGFGLYVLSPTSPPVSLSFSCSPYTP
TYAHLAAVACGLERFGQSHMPVVFLTHCNWIFSLLWELLPLWRARGF-LSSDGTPLPHPS
LLSYIIDLTSGLSSLPFIYRTSYRGSLFAVTVDTLAKEGAQGGDQCWNLPNDVPAP-VVT
PRTVCKRPDLLALQRSDSTLADTMAKLQAGQKVSNSSPFSSAFSSLSLDKESGLLMFKGD
KRPRVWVVPRQLRRDLIFAVHDGPMGAHQRPEETYRKLRLLGWWPGMQEHVRHYCRSCLF
CIPRNLLGSEVKVIESLW---P--LRS--TAPWSNLQIEVVGPVTVSEEGHKHVLIVADP
NTRWVEAFPLKPYTHTAVAQLLLQHVFARWGIPVRLEAAQGPQFARHVLVSCGLALGVHV
ASPSRDLQFPCLTSSGAYWEFKRALKEFIFLHGKKWAASLPLLHLAFRASSSQASPFHIL
TGAEERLTEPLWWEMSSANIEGLKMDLFLLQLMRELLELHWRLAEKTSEK---AENRRFK
RERQEKEWSVGDQVLVLSLPRNGSSAKWVGPFYIGDRLSPSLYRVWGFPTPEKLGCIYPS
SLMKPFAKSVTPLSFKVLEQ----

------------------------------------------------------------
--------------------------------------------------------MLL-
--SGGRPPAQEWFMVQSKS-KPRVHRQRLQVQRIFRVKVNAFQ----------SRPDNPY
FWLQLEGPRENTGKAKEYLKGLCSPELWKEVRYPPVLHCAFLGAQGLF-LDCLCWSTLAY
----------L---VPGPPGSLMVGGLTESFTMTQNWLEELVARLRWGPAPMTTPRGIWE
TEVTRAFGALVWIRGDQYARDLLQLPPAVQELLLSLVRDAAGKEDI-VDWLGHFGISSVC
---SN--------PEVL-----I-------------------------------------
-CPSQQQKEGSSLVTVGESPG---PFLEIGTWN------QASEN--SKGSTGLGAAGSLM
---------PAQSTQR----------ERACQLV-IRSNKQ---GD-ANSAREEGAI--VQ
AISSQDSANHTQA--------LLQQRQVQRMENR--MSLQS--PVSALSV------WAPG
PA--------FGPLWPGT------IAATFWKIN---ELQS----LHLAWLLSQACFNFPF
WQ-RPGVPIQLKLPGQTPLPLNLEWKPKELAPLPSAENQACRPDGEPG---RETALEHSP
KPEMPT-EVTSLSVVPGDCVIKEMVSSGPPQVGPSLTSIPQ-------ARVDS-ALSDGK
GLEKLSSSVLPTEQ------RGPTAQEKPVAQAEMTDQSVPKAPTLSET----LEMPTA-
--IAASKEGLPA----------APKVSAVCTEP---A-----------------------
-------------APKVPPAPS-----------------------------KPAAPTGN-
-----------ATKAGSA-----------------------------TPKTPSTTKAPAT
SKASRA-------------STTSAAQGPMAADVAKPLSEVQASKS-RAAGPKGQGKA-GR
QGLQASSTLASRNKHPFLREGLLGA-WEGAQRPSSHHPQ-----ANNTVTSFQRYHEALN
TPFELNLSGEPGNPGLRRVVIDGSSVAMVHGLQHFFSCRGIAMAVQYFWNRGHREV----
TVFVPTWQLKKNRRVRESHFLTQLHSLKMLSITPSQLENGKKITTYD-------YRFM-V
KLAEETDGIIVTNEQIHILMNNS-KKLMV-RDR---------------------------
LLPFTFAGNL------FMVPDDPLGRDGPTLDEFLKKPNRLDMDIGNFLKV----WKTLP
PSSASISELSDD-ADPEPLVAPQNVK------------ELMQ------------------
-------------GPGAPEPDEQDDHDSSLVSVFGAECPPFSEEILWCLSLHDPSEGALD
IDLLPVVSSPYVDAPWD--GKAPCQQVLAQLAQLTIPSNFTALSFFMGFMDSHRDVIPDY
EVLMGPLHSLLKQKPDWQWNQEHEKAFLALKRALVSALCLSTPNSHLPFYLEVTVSQVSL
TAILQQEHSGRKHPIAYTSKPLLPDEDSEGPQSGGDSPYAVAWALKHFSRYIGDNPVVLR
LSYASRTTVDNETWESHRVSKAWLIRWSLLVQDKGKRDLELTLLRGLLGENQLLTPA-SS
MPRVFQLLPPSTDLSTFICIHISGYCFYRDDELCAGFGLYILSPTSPPVSLAFSCSPYTP
TYAHLAAVACGLERFGQSRLPVVFLTHCNWIFTVLWELLPLWKARGF-LSSDGAALPHPS
LLSYIMSLTSGFSSLPFIYRTSYRGSLFAVTVDNLAKQGAQGGGQWWDLPKDVPVP-MVT
PHTKGRKPDLLALQLSDSTLADIIAKLQAGQRLSGPSPFSSAFNSLSLDKDSGLLMFKGE
KHPRVWVVPRQLRRDLIFSVHDIPLGGHQRPEETYKKLRLLGWWPGMQEHVKDYCRSCLF
CIPQNLTEGEFKVIESPWP-----LRS--TAPWSSLQIEVVGPVTASEEGHKYVLIVADA
NTRWVEAFPLKPYTHMAVAQVLLQHVFARWGVPMRLEAAQGPQFARHVLVSCGLALGAQV
TTLSRALQFPCLMSSEAYWEFKRALKEFIFLYGKKWAASLPLLHLAFRASTTEATPYQVL
TGGEMRLMEPLWWEMSTANIEGLKMDAFSLQLMRELLDVHWRVAEKASEK---ADNRRLK
REMQEKEWTVGDQVLLLSLPRNGSSAKWVGPFYIGDRLSLSLYRVWGFPTPEKLGCVYPS
SLMKAFANGSTPLSLSVSLSDLEL

------------------------------------------------------------
------------------------------------------------------------
----------------------------MPLGTILRVKLNAFQ----------SRPDTPY
FWLQLEGPRENTSKAKEYLKGLCSPELWKEVRYPPMLHCAFLGAQGLF-LDCLCWSTLAY
----------L---VPGPPGSLMVGGLTESFTMTQNWLEELVARLRWGPAPLLTPRGIWE
AEVTRAFGALVWIRGDQYAGDLLQLPPAVQELLLSLVRDAAGKEDI-IEWLSHFGISNTC
---S-P-------VALR-------------------------------------------
-SPPQQQKEDSAMVSTGESPG---SFLEMGTLQ-----NGGPEN--PKRLSSLGATRSLI
---------PAQSTQQ----------ETANQVVRVGSNNQ---SG-TDSDREEGL---VR
ATSSQDSVNHTPA--------LLQQKQVQKVEEK--FPFQP--PVSALGVYPSWKAWAPG
PA--------FGPLWPGT------IAAAFWRIN---QLHS----LHLAWLLSQACFSLPF
WQ-RPLGPIQLKLPGQSALPLNLEWKQKELAPLPSAESPACRPDGELVYKSTETTLQNCP
RPETPP-KVMSLLVVPGGSGEKDKVSPRLPLLAS--TTQ--LQAGGERRNQGS-LQPDCM
WLEKGPYPASPTEQGVL------TAQGRPMAQGGLTAQSAPEAGTVPETLKVPVAAVVPK
AENPPLTQGQPAAPKVPTSQMMPA-VSTEPAA----------------------------
--------PKVPLAPTMP------TAQVVST-AQKAAVDQPAL--ASAAQVMSTTPKTAM
AQKMLA---TKTSPASPKTLKAQTGPVTKMESA--APKASA------APKTSAAPKAPAA
SKASRAPQT--------PAVQKVPTGTGPTLDVARLLSEVQPSSKGDASLPKGQVEP-GR
QGVQSSSK-----------HQLLGG-WEGGPRQSPRHPQ-----VNSTVTSFQRYHEALN
TPFELNLSGEPGNQELRRVVIDGSSVAMVHGLQHFFSCRGIAMAVQYFWNRGHREV----
TVFVPTWQLKKNRRVRESHFLTKLHSLKMLSITPSQLENGKKIATYD-------YRFM-V
KLAEETDGVIVTNEQIHTLMNNS-KKLMV-KDR---------------------------
LLPFTFAGNL------FMVPDDPLGRDGPTLDEFLKKPNRLDTDIGNFLKV----WKTLP
PSSASISQLRDD-TDPRPLEGPQNVEEVREEKEERQDEEWR-------------------
---EGQG---------MPGWAEEDDLDSFLASVFRVECPSLSEEILQCLSLHDPPDGALD
IDLLPGVASSYLGIPWD--GKAPCQQVLAQLAQLTTPSNFTVLSFFVGFMDSHRDVIPDY
EALMGPLHSLLKQKPDWVWDQEHEKAFLALKRALVSALCLSAPNCQLPFRLQVTVSQVAL
TAILYQEHSGKKHPIAYTSKPLLPDEDSEGPQSGGDSPYAVAWALKHFSHCIGDDPVVLH
LVYASRTTVAPEAPECCRVSKAWLIRWSLLVQDRGKRALELALLQGLLGENRLLTPV-SS
MPRFFQVLPPFSDLSTFVCIHMSGYCFYREDEWCAGFGLYVLSPTSPPVSLSFSCSPYTP
TYAHLAAVACGLERCGQSHLPVVFLTHCNWIFSLLWELLPLWRARGF-LSSDGAALPHPS
LLSYIISLTSGLSSLPFIYRTSYRSSLFAVTVDNLAKQGAQGSGQWWDLPKDVPVP-VVT
SHTMGKRPNLLALQLSDSTLADIIAKLRAGQKLSVSSPFSSAFHSLSLDKESGLLMFKGD
KKPKVWVVPRQLRRDLIFSVHDIPMGAHQRPEETYKKLQLLGWWPGMQEHVKDYCRSCLF
CIPRNLTGSELKVIESPW---P--LRS--TAPWSNLQIEVVGPLTVSEEGHRHVLIVADP
NTRWVEAFPLKPYTHMAVAQVLLQHVFARWGVPVRLEAAQGPQFARHVLVSCGLALGAQV
TSLSRDLQFPCLVSSEAYWEFKRALKEFIFLHGRKWAASLPLLHLAFRASSTEATPFQVL
TGAERRLTEPLWWEMSSANIEGLKMDVFLLQLIGELLELHWRGAEKGTEK---ADNRRFK
QESQEKEWNVGDQVLLLSLPRNGSSAKWVGPFYIGDRLSLSLYRVWGFPTPEKLGCIYPS
SLMKPFAKSGTPLSFKVLEQ----

------------------------------------------------------------
--------------------------------------------------------MLL-
--SGGDPPTQEWFMVQAKS-KPRVQRQRLQVQRIFRVKLNAFQ----------SRPDTPY
FWLQLEGPRENTGKAKEYLKGLCSPELWKEVRYPPLLHCAFLGAQGLF-LDCLCWSTLAY
----------L---VPGPPGSLMVGGLTESFTMTQNWLEELVARLRWGPAPLLTPRGIWE
AEVTRAFGALVWIRGDQYAGDLLQLPPAVQELLLSLVRDAAGKEDI-IEWLSHFGISNTH
---SNQ-------EVLI-------------------------------------------
-CPPQQKKEGLAMVSMGESPG---SFLEMGTLQ-----KGGLES--PKRLTSLGATGSLI
---------PTQSTQQ----------ETANQLVRVGSSNQ---GG-KDRAQEEGP---LQ
ASSSQDSSNHSQT--------LLQQRQVQRVEDK--LPFQA--PVSALGVCPSWKAWAPG
PA--------FGPLWPGA------IAATFWRIN---ELHS----LHLAWLLSQAGFNFPF
WQ-RPLGPIQLKLPGQNPLPLNLEWKQKELTPLPSAESPACRPDGELG---GETALRNFP
RPETSP-KITSLLVVPAGSAVKDKLSPGLPQIGPPLTSVPQLQARGEPGDQGS-MPLDCK
GLEKGPSPARPSEQGMLTEQEVPTAQGGPMAQGHLTAQLVPEVQTVPETLKVPLGAAVRK
AENPPIIQGLPAAPKVPTAPVMPA-AHTEPAAPKVPS-----------------------
-------------GPTKP------AVSVMPT-TGKAAMDQPVTESALTAQVLSATPKTPT
AQKMPA---MKTSPVGPQTPKAQARPVPKSGST--ASKA------PAAPKTPVIPKAPAT
SKASRASKT--------PAPQKVPTDAGPTLDVAKLLSEVHPSSRGSTSSPKGQA-A-GR
QGPQPNSTLSLSSKHPFLMEGILGA-WEDTPRQPSRHQQ-----ASHTVTSFQRYHEALN
TPFELNLSGEPGNQELRRVVIDGSSVAMVHGLQHFFSCRGIAMAVQYFWNRGHREV----
TVFVPTWQLKKNRRVRESHFLTKLHSLKMLSITPSQLENGKKITTYD-------YRFM-V
KLAEETDGIIVTNEQIHILMNNS-KKLMV-KNR---------------------------
LLPFTFAGNL------FMVPDDPLGRDGPTLDEFLKKPNRLDTDIGNFLKV----WKTLP
PSSARISELSDA-ADAGPLQEPQSVEEVREEKEEQQEE---E-----------P------
--REEQGW--------PKLEEEGDDLDSSLASVFRAECPSLSEEILRCLSLHDPPDGALD
IDLLPGVASPYLGIPWD--GGAPCQQVLTQLAQLSIPSNFTALSFFVGFMDSHRDAIPDY
EALMGPLHSLLRQKPDWQWDREHEKAFLALKRALVSALCLTAPNSQLPFRLEVMVSQVAL
TAILHQEHSGRKHPIAYTSKPLLPDEESEGPQSGGDSPYAVAWALKHFSRCIGDTPVVLD
LCYASRTTADPEAREGRRVSKAWLIRWSLLVQDKGKRALELTLLQGLLRENRLLMPA-SS
MPRFFQVLPPFSDLSTFVCIHMSGYCFYREDEWCAGFGLYVLSPTSAPVSLSFSCSPYTP
TYAHLAAVACGLERFGQSQLPVVFLTHCNWIFSLLWELLPLWRARGF-LSSDGAPLPHPS
LLSYIISLTSGLSSLPFIYRTSYRGSLFAVTVDTLAKQGAQGAGQWWNLPKDVSVP-VVT
PHTMGKKPNLLALQLSDSTLADIIAKLQAGQKLSGSSPFSSAFNSLSLDKESGLLMFKGD
KKPRVWVVPTQLRRDLIFSVHDIPMGAHQRPEETYKKLRLLGWWPGMQEHVRDYCRSCLF
CIPRNLVGSELKVIESPW---P--LRS--TAPWSNLQIEVVGPVTVSEEGHKHVLIVADP
NTRWVEAFPLRPYTHVAVAQVLLQHVFARWGVPVRLEAAQGPQFARHVLVSCGLALGAQV
TTLSRDLQFPCLASSEVYWEFKRALKEFIFLHGKKWAASLPLLHLAFRTSSSEATPFQVL
TGGEVRVSEPLWWEMSSANIEGLKMDIFLLQLIRELLDLHCRVAEKASEK---ADNRRFK
RESQEKEWNVGDQVLLLSLPRNGSSAKWVGPFYIGDRLSLSLYRVWGFPTPEKLGCIYPS
SLMKAFAKNGTPLSFKVLEQ----

------------------------------------------------------------
--------------------------------------------------------MLL-
--SGGDPPAQEWFMVQTKS-KPRVQRQRLQVQRIFRVKLNAFQ----------SRPDTPY
FWLQLEGPRENMGKAKEYLKGLCSPELWKEVRYPPILHCAFLGAQGLF-LDCLCWSTLAY
----------L---VPGPPGSLMVGGLTESFIMTQNWLEELVGRLRWGPAPLLTPRGIWE
AEVTRAFGALVWIRGDQHAGDLLQLPPAVQELLLSLVRDAAGKEDI-IEWLSRFGISDSH
---SDP-------EVLI-------------------------------------------
-CPPQQQKEAPAMVSVGESPG---PFVDMGTLQ-----NRGPEN--SKRLSSLGATGSLI
---------PAQSTPQ----------EAANQLVRVGSNNQ---DG-MDSAQEEGS---VQ
ATSSQDSTNHTQA--------LLKQRQVQKIEDK--LLFQP--PVSALGVCPPWKAWTPG
PA--------FGPLWPGA------IAATFWRIN---ELHS----LHLAWLLSQACFNFPF
WQ-RPLGPIQLKLPGQNPLPLNLEWKQKELAPLPSAESPAGRPDGGLG---GEAALQNCP
RPEISP-KVTSLLVVPGSSDVKDKVSSDLPQIGPPLTSTPQLQAGSEPGDQGS-MQLDFK
GLEEGPSPVLPTG------------QGKPVAQGGLTDQSVPGAQTVPETLKVPMSAAVPK
AENPPRTQVPSAAPKVPTSPMMLA-VHTEPAAPEVPL-----------------------
-------------APTKP------TAQLMAT-AQKTVVNQPVL----VAQVEPTTPKTPQ
AQKMPV---AKTSPAGPKTPKAQVGPAATVSKAPAASKA------------PAAPKVPVT
PRVSRAPKT--------PAAQKVPTDAGPTLDVARLLSEVQPTSRASVSLLKGQGQA-GR
QGPQSSGTLALSSKHQFQMEGLLGA-WEGAPRQPPRHLQ-----ANSTVTSFQRYHEALN
TPFELNLSGEPGNQGLRRVVIDGSSVAMVHGLQHFFSCRGIAMAVQFFWNRGHREV----
TVFVPTWQLKKNRRVRESHFLTKLHSLKMLSITPSQLENGKKITTYD-------YRFM-V
KLAEETDGIIVTNEQIHILMNNS-KKLM--VKDRL-------------------------
-LPFTFAGNL------FMVPDDPLGRDGPTLDEFLKKPNRLDTDIGNFLKV----WKTLP
PSSASVTELSDD-ADSGPLESLPNMEEVREEKEERQDE---E-----------Q------
--RQGQGT--------QKAA-EEDDLDSSLASVFRVECPSLSEEILRCLSLHDPPDGALD
IDLLPGAASPYLGIPWD--GKAPCQQVLAHLAQLTIPSNFTALSFFMGFMDSHRDAIPDY
EALVGPLHSLLKQKPDWQWDQEHEEAFLALKRALVSALCLMAPNSQLPFRLEVTVSHVAL
TAILHQEHSGRKHPIAYTSKPLLPDEESQGPQSGGDSPYAVAWALKHFSRCIGDTPVVLD
LSYASRTTADPEVQEGRRVSKAWLIRWSLLVQDKGKRALELALLQGLLGENRLLTPA-AS
MPRFFQVLPPFSDLSTFVCIHMSGYCFYREDEWCAGFGLYVLSPTSPPVSLSFSCSPYTP
TYAHLAAVACGLERFGQSPLPVVFLTHCNWIFSLLWELLPLWRARGF-LSSDGAPLPHPS
LLSYIISLTSGLSSLPFIYRTSYRGSLFAVTVDTLAKQGAQGGGQWWSLPKDVPAP-TVS
PHAMGKRPNLLALQLSDSTLADIIARLQAGQKLSGSSPFSSAFNSLSLDKESGLLMFKGD
KKPRVWVVPTQLRRDLIFSVHDIPLGAHQRPEETYKKLRLLGWWPGMQEHVKDYCRSCLF
CIPRNLIGSELKVIESPW---P--LRS--TAPWSNLQIEVVGPVTISEEGHKHVLIVADP
NTRWVEAFPLKPYTHTAVAQVLLQHVFARWGVPVRLEAAQGPQFARHVLVSCGLALGAQV
ASLSRDLQFPCLTSSGAYWEFKRALKEFIFLHGKKWAASLPLLHLAFRASSTDATPFKVL
TGGESRLTEPLWWEMSSANIEGLKMDVFLLQLVGELLELHWRVADKVSEK---AENRRFK
RESQEKEWNVGDQVLLLSLPRNGSSAKWVGPFYIGDRLSLSLYRIWGFPTPEKLGCIYPS
SLMKAFAKSGTPLSFKVLEQ----

------------------------------------------------------------
--------------------------------------------------------MPTW
-GAGSS--SPDRFAVSAEA-EDKVREQQPHVERIFRVGMSVLP---------KDCPENPH
IWLQLEGPKENASRAKEYLKGLCNPELQNEIHYPPKLHCIFLGAQGFF-LDCLAWSTSAH
----------L---VPGAPGSLMVSGLTEAFVMVQSRVEELVERLSWEFLPGPSPGASQC
AGVLRDFSALLQSRVDAYTEALLQLPLAIQEELLSLVQEASRGQGPQA----FPSWE-QG
S----P-------GL----H--Q----EVRTP-LSEG----RESLD------TGPTGWRE
SR------------------------------------------DE-----R--------
----------------------------------H----ALEKEREKQGAPRET----DL
GWKELPRE-------------------------------------ETWERQ------GAF
G-----------SQIGG----------------------------------GEA-GQA--
-----APL-KGKALGKEGVP----------------QEKGR-FWVQGE---PPGAQGPCQ
KAA-----------------------------------------QPRGASLLQRLHN--G
KASPPRV-----------------------------------------------------
-------------PSPPPA-----------------------------------------
--------------PEPPWHCGDRGD---------R------------------------
------------------------------------------------------------
------ADK----------QQV---------------VARGRG----S--P---------
--------------------------WKRG------TRG-----G-NLVTGTQRFQEALQ
DPFTLCLANVPGQPDLRHIVIDGSNVAMVHGLQHYFSSRGIAIAVQYFWDRGHRDI----
TVFVPQWRFSKDSKVREGHFLHKLYSLSLLSLTPSRVLDGKRISSYD-------DRFM-V
KLAEETDGIIVSNDQFRDLAEESEKWMAIIRER---------------------------
LLPFTFVGNL------FMVPDDPLGRNGPTLDEFLKKPVRA-QGSS-KAQHSARGFAEHG
----------------------------------NQ------------------------
--------------QQ--GKKEEEKGSGG--LRKTRETERLRRQLLEVFWGQDHKV---D
FIL---------------QREPYC-RDINQLSEALLSLNF--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
--------------------------------------------------------MPTW
-GARPA--SPDRFAVSAEA-ENKVREQQPHVARIFSVGVSVLP---------KDCPDNPH
IWLQLEGPKENASRAKEYLKGLCSPELQDEIHYPPKLHCIFLGAQGFF-LDCLAWSTSAH
----------L---VPRAPGSLMISGLTEAFVMAQSRVEELAERLSWDFTPGPSSGASQC
TGVLRDFSALLQSPADAHREALLQLPLAVQEELLSLVQEASSGQGPGA----LASWE-RR
S----S-------GLLGPQC--Q----GVRAP-PSDG----RESLD------TGSMGPGD
SR------------------------------------------GAR--GDS--------
----------------------------------Y----AVVKEGGKQGGPREM----DL
GWKELPGE-------------------------------------EAWERE------VAL
S-----------HSQWLE----------------------------------G-------
-----------K---GVKIA----------------QGGGG-FCVHRE---PAGAHGSCH
RAA-----------------------------------------QSRGASLLQRLHN--G
NASPPRV-----------------------------------------------------
-------------PSPPPA-----------------------------------------
--------------PEPPWHCGDRGDCGDRGDG-DR------------------------
------------------------------------------------------------
------GDK----------QQG---------------MARGRG----P--Q---------
--------------------------WKRG------ARG-----G-NLVTGTQRFKEALQ
DPFTLCLANVPGQPDLRHIVIDGSNVAMVHGLQHYFSSRGIAIAVQYFWDRGHRDI----
TVFVPQWRFSKDAKVRESHFLQKLYSLSLLSLTPSRVMDGKRISSYD-------DRFM-V
KLAEETDGIIVSNDQFRDLAEESEKWMAIIRER---------------------------
LLPFTFVGNL------FMVPDDPLGRNGPTLDEFLKKPART-QGSS-KAQHPSRGFADHG
----------------------------------KQQ-----------------------
---------------Q--G-REEEKGSGG--IRKTRETERLRRQLLEVFWGQDHKV---D
FIL---------------QREPYC-RDINQLSEALLSLNF--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
--------------------------------------------------------MSIW
-GFASP--TPDRFAVSAEA-EDKVREQQARLERIFSVGMSVLS---------KDCPENPH
IWLQLEGPKENICRAKEYLKGLCSPELQSEIRYPPRLHCIFVGAQGFF-LDCLAWSTSAH
----------L---VPLVPGSLMISGLTEAFVMAQSRVEELAQRLSWGLLPLSCPGALDN
GRVLRDFSALLQTREDAYTEALLQLPLAVQEELLSLVQEASRGQGPQT----LPSHE-VG
S----P-------GMLSSQY--Q----GVRAP-LSED----RESLA------TGVAGLGK
SQ------------------------------------------AVR--GPS--------
----------------------------------H----AVEKEGRKQDAVRDM----GS
GWKEPSGE-------------------------------------EVCETG------VAF
R-----------SQLAGG----------------------------------GA-EE---
-----VAPLKGRAFGKQEVP----------------QQRGG-FGVQGE---PSGAHVPCQ
RAA-----------------------------------------PTRGASLLQRLHN--G
NTSPLRV-----------------------------------------------------
-------------PSPPPA-----------------------------------------
--------------PEPPWPCGDRDR--DRD-RGDR------------------------
------------------------------------------------------------
------GDK----------QQA---------------GARGRG----S--P---------
--------------------------WKRG------TRG-----G-NLVTGTQRFQEALQ
DPFTLCLANVPGQPDLRHVVIDGSNVAMVHGLQHYFSSRGIALAVQYFWDRGHRDI----
TVFVPQWRFSKDSKVRESHFLQKLYSLSLLSLTPSRVMDGKRISSYD-------DRFM-V
KLAEETDGIIVSNDQFRDLAEESDKWMAIIRER---------------------------
LLPFTFVGNL------FMVPDDPLGRNGPTLDEFLKKPVRK-QGSS-KSQQPSKGPTEHG
----------------------------------HQQ-----------------------
--------------QGKEV---E-KGSGG--IRKTRETERLRRQLLEVFWGQDHKV---D
FIL---------------QREPYC-RDINQLSEALLSLNF--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
--------------------------------------------------------MLL-
--SGGRPPAQEWFMVQSES-KSRVQRQRLQVQRIFRVKVNAFQ----------SRPDTPY
FWLRLEGPQENTGKAKEYLKGLCNPELWKEVRYPPVLHCAFLGAQGLF-LDCLCWSTLAY
----------L---VPGPPGSLMVGGLTESFTMTQNWLEELVARLRWGSVPMVTPRGGWE
TEVTRAFGALVWIRGDKYAGDLLQLPPAVQELLLRLVRDAAGKEDI-IEWLGRSGISSTC
---SI--------PEVL-----I-------------------------------------
-SPAQQQKEGSSLVTIGESPE---PFLEIGTFN------QASEN--SKRLTSVGAAGSLM
---------PARSTEL----------ETECQ---IRSNKQ---GE-VNRAQEEGPI--VQ
VISSQVSANPTQA--------LLPQRQVQRMEDRR-ISLQS--PVSALSVCPSWKSRAPR
PA--------FRLLWPGT------IAATFRKIN---ELHS----LHLAWLLSQACFSLPF
WQ-RPMGPIQLRLPGQSPLPLNLEWKPKELTPLPSIENQPCREDGELG---KETALEHNP
RPEDPP-EAVCLSVVPADRAIKEGVSSGLPQAGPSLTSIPQ-------DAVES-APSDCR
GLEKLSSSALPTEQ------RGPAAQERPVAQAGMTGQSAPKAPTVSETLETPVATAVSK
AEHPPAEEGLPAAPKGPPALKK----SAVYAEP---P-----------------------
-------------APTVPPAPP-----------------------------TSAVPVAPT
A---P-----KPTEAAVG-----------------------------QP------AAPAA
STAPKA-------------ATGSTVAGPASDAVQ-LPSEAQASNSRAATPPKGQGKA-GR
QALQASSPVASRNKHQFLKEGILGA-WEEAQRQSPHHPQ-----ASSTVTSFQRYHEALD
TPFELNLSEEPGNPGLRRVVIDGSSVAMVHGLQHFFSCRGIAMAVQYFWNRGHREV----
TVFVPTWQLKKTRRVRESHFLTQLHALKMLSITPSQLENGKKITTYD-------YRFM-V
KLAEETDGIILTNEQIHILMNNS-KKVMI-RDR---------------------------
LLPFTFAGNL------FMVPDDPLGRDGPTLDEFLKKPNRLDMDIGNFLKV----WKTLP
PSSASISELSDD-ADPEPLVAPQNGEA---------------------------------
-------------EPELSKPEEQDDHGSSLGSAFGVECLAFPEEILRSLSLHDPSEGALD
IDLLPVVSSPYLDVPWD--GKAPSQQVLAQLAQLTIPSNFTALSFFMGFMDSHRDAIPDY
EALVGPLHSLFKQKPDWQWNQEHEKAFLALKRALVSALCLSTPNSLLPFYLEVTVSQVSL
TAILQQEHSGRKHSIAYTSKPLLPDEDSEGPQSGGDSPYAVAWALKHFSQCIGDNPVVLR
LSYAARTTADNEAWESRKVSKAWLIRWSLLVQDKGKRELELALLQGLLGENQLLTPA-AS
MPRVFQLLPPLTDLSTFICIHISGYCFYRDDELCAGFGLYILSPTSPPVSLTFSCSPYTL
TYAHLAAVACGLERFGQAHQPVVFLTHCNWIFSVLWELLPLWKARGF-LSSDGASLPHPS
LLSYILSLTSGFSSLPFIYRTSYRGSLFAVTVDNLAKQGAQGGGQWWDLPKDVPAP-MVT
PHTKGRKPNLLTLQLSDGTLADVITKLQTGQKLPGSSPFSSAFHSLSLDKDTGLLMFKGE
KHPRVWVVPRQLRRELIFSVHDIPLGGHQRLEETYKKLRLLGWWPGIKEHVRDYCRSCLF
CIPRNLVGGELKVIESPLP-----LRS--TAPWSSLQIEVVGPVTASEEGHKHVLIVADA
NTRWVEAFPLKPYTHMAVAQVLLQHVFARWGVPLRLEAAQGPQFARHVLVSCGLALGAQV
TTLSRALQFPCLMSSEAYWEFKRALKEFIFLHGKKWASSLPLLHLAFRASTPDATPYQVL
TGDEMRLTEPLWWELSSANIEGLKMDAFLLRLMRELLDLHWRVAEKASEK---AENRRLK
RETQEKEWNVGDQVLLLSLPKNGSSAKWVGPFYIGDRLSLSLYRVWGFPTPEKLGCVYPS
SLMKGFVNSDTALPLNV-------

------------------------------------------------------------
--------------------------------------------------------MPTW
-GAGSP--TPDRFTVSAEA-EEKVRAQQSRLERIFSVGVSVLP---------KDCPENPH
IWLQLEGSKENVGRAKEYLKGLCSPELQNEIHYPPRLHCIFLGAQGFF-LDCLAWSTSAH
----------L---VPGAPGSLMISGLTEAFVMAQSRVEDLV-----DFRPGSYPMTSQS
AGVLRDFSALLQPWEDTHTEALLQLPLAVQEKLLSLVQEASRGHGPFH--------G-EG
S----P-------GLLGALH--Q----GVRPS-LSEG----GESLD------AGSVGQGE
SR------------------------------------------GAS--GVS--------
----------------------------------H----TVE-NRGKQGGLREV----DQ
GWKELLGE-------------------------------------EAWEKE------VTF
R-----------SQPAGG----------------------------------GT-GE---
-----MGFLKGMALGKEGVP----------------QQRGG-SGVQCE---PPGAQGHSQ
KAA-----------------------------------------QSRGASLLQRLHN--G
EASPLRV-----------------------------------------------------
-------------PSPPPA-----------------------------------------
--------------PEPPWPCGDRGD------LGDR------------------------
------------------------------------------------------------
------GDK----------QQ-----------------ARGRG----S--P---------
--------------------------WKRG------TRG-----G-NLVTGTQRFQEALQ
DPFTLCLANVPGQPDLRHIVIDGSNVAMVHGLQHYFSSRGIAIAVQYFWDRGHRDI----
TVFVPQWRFSKDGKVREIHFLQKLYSLSLLSLTPSRVMDGKRISSYD-------DRFM-L
KLAEETSGIIVSNDQFRDLAEESDQWMAIIRER---------------------------
LLPFTFVGNL------FMVPDDPLGRNGPTLDEFLKKPARK-QLSS-KAQHPSKGFAGYG
----------------------------------NQQ-----------------------
--------------QGRE----EEKGSGG--IRKTRETERLRRQLLEVFGGQDHKV---D
FIL---------------QREPYC-RDINQLSEALLSLNF--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
--------------------------------------------------------MPTW
-EARPA--SPDRFAVSAEA-ENKVREQQPHVERIFSVGVSVLP---------KDCPDNPH
IWLQLEGPKENASRAKEYLKGLCSPELQDEIHYPPKLHCIFLGAQGFF-LDCLAWSTSAH
----------L---VPRAPGTLMISGLTEAFVMAQSRVEELTERLSWDFTPGPSSGASQC
TGVLRDFSALLQSPGDAHREALLQLPLAVQEELLSLVQEASSGQGPGA----LASWE-GR
S----S-------GLLRAQC--Q----EERAP-PSDG----RESLD------TGSVGPRD
SR------------------------------------------GAR--GDN--------
----------------------------------Y----AVEKEGGKQGGPREM----DL
GWKELPGE-------------------------------------EAWERE------VAL
R-----------PQSVGG----------------------------------GL-RES--
-----APL-KGKALGKEEVT----------------QGGGG-VCVHRE---PPGAHGSCH
RAA-----------------------------------------QSRGASLLQRLHN--G
NASPPRV-----------------------------------------------------
-------------PSPPPA-----------------------------------------
--------------PEPPWHCGDRGDWGDRGDGGDR------------------------
------------------------------------------------------------
------GDK----------QQG---------------MARGRG----P--Q---------
--------------------------WKRG------ARG-----G-NLVTGTQRFKEALQ
DPFTLCLANVPGQPDLRHIVIDGSNVAMVHGLQHYFSSRGIAIAVQYFWDRGHRDI----
TVFVPQWRFSKDSKVRESHFLQKLYSLSLLSLTPSRVMDGKRISSYD-------DRFM-V
KLAEETDGIIVSNDQFRDLAEESEKWMAIIRER---------------------------
LLPFTFVGNL------FMVPDDPLGRNGPTLDEFLKKPART-QGSS-KAQHPSRGFAEHG
----------------------------------KQQ-----------------------
---------------H--G-REEEKGSGG--IRKTRETERLRRQLLEVFWGQDHKV---D
FIL---------------QREPYC-RDINQLSEALLSLNF--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
--------------------------------------------------------MLL-
--SGGDPPAQEWFMVQTKS-KPRVQRQRLQVQRIFRVKLNAFQ----------SRPDTPY
FWLQLEGPKENMSKAKEYLKGLCSPELWKEVRYPQALHCAFLGAQGLF-LDCLCWSTLAY
----------L---VPGPPGSLMVGGLTESFVMTQ--MEGVVGRLRWGPAALLTPRGIWE
AEVTRAFGALVWIRGDQYAGDLLQLPPAVQELLLSLVRDAAGKEDI-IEWLSRIGPSDLR
---SDP-------EVLI-------------------------------------------
-CPPHQQKEGPAMVSVGDGPG---PFLEVGTLQ-----NRSQEH--SKRLTSLGATRALV
TAT------PGQNTQQ----------EAARASSRVDSNSH---GG-TDSARDEGP---AR
ATGSQDSATHTQA--------LSQQRQGQRVEDK--LSFQP--PVSALGVCPPWKAWTPG
PA--------FGPLWPGA------IAATFWRIN---ELHS----LHLAWLLSQACFSFPF
WQ-RPLGPIQFKLPGQNPLPLNLEWKQKELVPLPSMEGPDCRPDAGPG---GDVALQNCP
RPETPQ-KVMSLLVVSGGSGVKDKTSSGLPQIGPPSTSVAQLQAGSEPGDQGS-GQWDSK
GPEEGPFPAPPPGQGVS------TAQGVPMAQGEPSAPSVPDAQTVPETLEVPMAAAVAT
AQTPPTNQGPPAVPKVPTAQTTLA-VHAETAALEVPS-----------------------
-------------APTKPAAQG------VPT-AQKAAGAPPAS----AAPAVPAAPRAPT
AQKMPV---AKSSPAGPRALKAQTGPAAKTGSA--APRAPAAPKASRAP-----------
-------KP--------PAAQKTPTSS----GAAKLLSEGQPSSRGNASFPKGQGEA-ER
QGPQSGSTSAPSSKHQPQMEGVLGA-REGAPRQPPRHPQXRMAQANSTVTSFQRYHEALN
TPFELNLSGEPGNQALRRVVIDGSSVAMVHGLQHFFSCRGIAMAVQYFWNRGHREV----
TVFVPTWQLKKNRRVRESHFLTKLHSLKMLSITPSQLENGKKIATYD-------YRFM-V
KLAEETDGIIVTNEQLHVLMNNS-KKLMV-KDR---------------------------
LLPFTFAGNL------FMVPDDPLGRDGPTLDEFLKKPNRLDTDVGNFLKV----WKTLP
ARSAGASEPGDG-ADPAPREGLRDTEEVKEEKGE-GQD----------E---EQ------
--GQGPVVQ---EP------AEEDAPDSSLASVFRAECPSLSEELLRCLSLHDPPDGALD
IDLLPAPASPYLGIPWD--GKAPCQQVLAQLAQLTVPSNFTALSFFVGFMDSHRDVIPDY
EALVGPLHGLLKQKPDWQWDWEHEKAFLALKRALVSALCLTAPNAQLPFRLEVTVSQVAL
TAVVYQEHSGRKHPIAYTSKPLLPDEESEGPQSGGDSPYAVAWALKHFSRCIGDTPVVLD
LSYASRTTVGPETREGRKVSKAWLIRWSLLVQDKGKRALELTLLQGLLGENRLLTPA-SS
MPRFFQVLPPFSDLSTFVCIHMSGYCFYREDEWCAGFGLYVLSPTSAPVSLSFSCSPYTP
TYAHLAAVACGLERFGQSRLPVVFLTHCNWVFSLLWELLPLWRARGF-LSSDGAPLPHPS
LLSYIISLTSGLSSLPFIYRTSYRGSLFAVTVDTLAKQGAQGGGRWWDLPKDVPAP-VVS
PHTMGKRPDLLALQRSDSTLAEIIAKLRAGQKLPGSSPFSSVFNSLSLDQESGLLMFKGD
KRPKVWVVPRQLRRDLIFSVHDLPLGAHQRPEETYKKLRLLGWWPGMQEHVRDYCRSCLF
CIPRSLPGSDLKVIESPW---P--LRS--TAPWSTLQIEVVGPVTISEEGHKHVLIVADA
NTRWVEAFPLKPYTHTAVAQLLLQHVFARWGVPVRLEAAQGPQFARHVLVSCGLALGAQA
ASLSRDLQFPCLTSSDAYWEFKRALKEFIFLHGKKWAASLPLLHLAFRASSAQATPVQIL
TGDEVRLSEPLWWEISSANIEGLKMDVFLLQLIGELLEVHWRVADKPSEK---AENRRFK
RESQEKEWNVGDQVLLLSLPRNGSSAKWVGPFYIGDRLSLSLYRVWGFPTPEKLGCIYPC
SLMKAFAKSGTPLSFKVLEQ----

------------------------------------------------------------
--------------------------------------------------------MPAP
CPRSSPTQHPSQFRMTT---------------------NSSLSPPSLPHPP--GKAGAGQ
SWLQLQGPRQELQKAKDYIKGLCNPELSEEVCYPKDMQCVFVGAQGLF-LDCLTKGTSAH
----------L---VLLNPGSLLVSGLAEAFVMAQSRIQEFVEKYQKTPRLP----DEQD
VLVKKAFRELVEFHDDKHAMDLLILPTPLKEELLNLVRDIQEEDGARAPWNGASWWEAKA
AGGGRPQGQSQ--DFFDISRPPDRTKLEGERPALYER----------SS---KPTPGWGT
SQ---------------------------------------------------EAQ----
-E--------------------DSTLP----RSQD----VAR--GVEERGPE--------
---ETSQDEEEK-------------------------EPSVGALSSSWTEKEFQMMLNFF
KTMGYEERVVKKVLKDGG-VR-ETPSQILDRVQMEQASFSRQERGPVPFQEPRA-REM--
SSPPPPPPPPPPSL-PPSLE----------------STQHENEYLLEV---IKAAAANCG
HCPSEI---------PAELQT-----------------------GAPLAGLLRKLNE--K
ANRQEEARVE-----------------------------------------------NGP
EHRGSRREGVPALSNGK-----VY------------------------------------
--------------LQGPPHCEPE--RKDGSCLHRAVRGPP-------------------
--------------PFS--------------------------------ESSDFPMDV--
---------------------------------------TPVA----S--P---------
-------------------------AWAAEESQPTVDMD-----PVPTVTGAQRFKEAIQ
TPFKLNLANTPGKKNLRRIIIDGSNIAMVHGLHQFFSCRGIALAVQYFWDRGHREV----
TVFVPQWRMGKAARVEGKKGVGRAGG----------------------------------
----TDHGPAFADCAPSSIPGDSPSWSCVILYLCHP-----------------------R
AFHYPFPGLA------P-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
--------------------------------------------------------MPTW
-GAGSP--PPDRFTVSAEA-EAKVRAEQAHLERIFRVGVCILP---------KDCPENPH
IWLQLEGSKENIGRAKEYLKGLCSPELQNAIHYPPRLHCIFVGAQGFF-LDCLVWSTSAH
----------L---VPGVPGSLMISGLTEAFVMAQSRVEELVERLSWDLQTGLYPTTSQN
AGVLREFSALLQPREDAHTEALLQLPLAVQEELLSLAQEAFMGQGPL-------------
----------------GVLH--Q----GVRAP-LSEG----RESLD------AGCVGQGE
SK------------------------------------------GAS--GVS--------
----------------------------------H----TMEKNIGKQGGPREM----DL
WFKELLGE-------------------------------------EAWEKE------ATF
R-----------SQPAGG----------------------------------GV-GG---
-----MGCLKGMALAGEGVT----------------QERGG-FSVQGE---PPGPQGPCQ
RSA-----------------------------------------QSRGASLLQRLHN--G
EASPPRV-----------------------------------------------------
-------------PSPPPA-----------------------------------------
--------------PEPPWPCGDLGD------LGDR------------------------
------------------------------------------------------------
------GDK----------QQ-----------------GRGRG----S--S---------
--------------------------GKRG------TRG-----G-NLVTGTQRFQEALQ
DPFTLCLANVPGQPDLRHIVIDGSNVAMVHGLQHYFSSRGIAIAVQYFWDRGHRDI----
TVFVPQWRFSKDGKVREIHFLQKLHSLSLLSLTPSRVMDGKRISSYD-------DRFM-L
KLAEETSGIIVSNDQFRDLAEESDKWMAIIRER---------------------------
LLPFTFVGNL------FMVPDDPLGRNGPTLDEFLKKPARK-QVSS-KAQPTSKGFSGHS
----------------------------------NQQ-----------------------
--------------QGKE----EEKGSGG--IRKTRETERLRRQLLEVFWGQDHKV---D
FIL---------------QREPYC-RDINQLSEALLSLNF--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
--------------------------------------------------------MLL-
--SGGDPPAQEWFMVQTKS-KPRVQRQRLQVQRIFRVKLNAFQ----------SRPDTPY
FWLQLEGPKENMSKAKEYLKGLCSPELWKEVRYPQALHCAFLGAQGLF-LDCLCWSTLAY
----------L---VPGPPGSLMVGGLTESFIMTQNWLEELVGRLRWGPAALLTPRGIWE
AEVTRAFGALVWIRGDQYAGDLLQLPPAVQELLLSLVRDAAGKEDI-IEWLGRIGTSESR
---SDP-------EVLI-------------------------------------------
-CPPHQQKEGPAMVSVGDGPG---PFLEVGTLQ-----NRNQEH--SKRLTSLGATRALV
LGA------PGQNTQQ----------ETANQLVRVNSNSH---GG-ADSGREEGP---AR
ATSSQDSAPHAQA--------LSQEKPGQRAEDK--VPFQP--PVSALGLCPPWKAWTPG
PA--------FGPLWPGA------IAATFWRIN---ELHS----LHLAWLLSQACFSFPF
WQ-RPLGPIQFKLPGQNPLPLNLEWKQKELVPLSSMESPECRPEAGPG---GEAALQNCP
RPETPP-KVMSVLVVSGGSGVKDKTSPGLPQIGPPLTSVPPLQTGSEPGDQGS-GQWDSK
GPEEGPFPALLPGQGVS------TAQGGPVAQGGLTAPSVPDAQTVPETLEVPMAAAVAT
AQTPPADQGLPAVPKVPTAQTTLA-VPAEPAALEVPS-----------------------
-------------APTKPAAPG------VPS-AQKTAVAPPAS----ATPGAPANPKAPA
AQKTPS---AKSSPAGPKAPKAQTGPLAKTGSA--GPKAPRAPKT---------------
------------------AAQKTLADSGPVLGAAKLPSEGQSSSRGDASFPKGKAEA-ER
QGPQSGSTSAPSRKHQAQTEGFLGA-REGAPRQPPRHPQ-----ANSTVTSFQRYHEALN
TPFELNLSGEPGNQGLRRVVIDGSSVAMVHGLQHFFSCRGIAMAVQYFWNRGHREV----
TVFVPTWQLKKNRRVRESHFLTKLHSLKMLSITPSQLENGKKITTYD-------YRFM-V
KLAEETDGIIVTNEQLHILMNNS-KKLMV-KDR---------------------------
LLPFTFAGNL------FMVPDDPLGRDGPTLDEFLKKPNRLDTDVGNFLKV----WKTLP
PSSASTSEPSDG-VDLVPPESLPNIEDVQEEKE--GQD----------E---EQ------
--REGQGAQ---EL------PEEDAPDSSLASVFMAECSSLSEEILRCLSLHDPPDGALD
VDLLPAPASPYLGIPWD--GKAPCQQVLAQLAQLTIPSNFTALSFFVGFMDSHRDVIPDY
EALVGPLHSLLKQKPDWQWDWEHEKAFLALKRALVSALCLTAPNAQLPFRLEVTVSQVAL
TAVVYQEHSGRKHPIAYTSKPLLPDEESEGPQSGGDSPYAVAWALKHFSRCIGDTPVVLD
LSYASRTTVGPETQEGRRVSKAWLIRWSLLVQDKGKRALELTLLQGLLGENRLLTPA-SS
MPRFFQVLPPFSDLSTFVCIHMSGYCFYREDEWCAGFGLYVLSPTSAPVSLSFSCSPYTP
TYAHLAAVACGLERFGQSRLPVVFLTHCNWIFSLLWELLPLWRARGF-LSSDGAPLPHPS
LLSYIISLTSGLSSLPFIYRTSYRGSLFAVTVDTLAKQGAQGGGQWWDLPKDVPVP-VVS
PHTMGKRPDLLALQQSDSTLAEVIAKLRVGQKLPGSSPFSSVFNSLSLDQESGLLMFKAD
KRPRVWVVPRQLRRDLIFCVHDPPLGGHQRPEETYKKLRLLGWWPGMQEHVRDYCRSCLF
CIPRNLTGSDLKVIESPW---P--LRS--TAPWSTLQIEVVGPITISEEGHKHVLIVADP
NTRWVEAFPLKPYTHTAVAQVLLQHVFARWGVPVRLEAAQGPQFARHVLVSCGLALGAQA
ASLSRDLQFPCLTSSDAYWEFKRALKEFIFLHGKKWAASLPLLHLAFRASSTQATPVQIL
TGDEVRLGKPLWWEMSSANIEGLKMDVFLLQLIGELLELHWRVADKASEK---AENRRFK
RESQEKEWNVGDQVLLLSLPRNGSSAKWVGPFYIGDRLSLSLYRVWGFPTPEKLGCIYPS
SLMKAFAKSGTPLSFKVLEQ----

------------------------------------------------------------
--------------------------------------------------------MLL-
--SGGDPPAQEWFMVQTKS-KPRVQRQRLQVQRIFRVKLNAFQ----------SRPDTPY
FWLQLEGPRENMGKAKEYLKGLCSPELWKEVRYPPILHCAFLGAQGLF-LDCLCWSTLAY
----------L---VPGPPGSLMVGGLTESFIMTQNWLEELVGRLRWGPAPLLTPRGIWE
AEVTRAFGALVWIRGDQHAGDLLQLPPAVQELLLSLVRDAAGKEDI-IEWLSRFGISDSH
---SDP-------EVLI-------------------------------------------
-CPPQQQKEAPAMVSVGESPG---PFVDMGTLQ-----NRGPEN--SKRLSSLGATGSLI
---------PAQSTPQ----------EAANQLVRVGSNNQ---DG-MDSAQEEGP---VQ
ATSSQDSTSHTQA--------LLKQRQVQKIEDK--LLFQP--PVSALGVCPPWKAWTPG
PA--------FGPLWPGA------IAATFWRIN---ELHS----LHLAWLLSQACFNFPF
WQ-RPLGPIQLKLPGQNPLPLNLEWKQKELAPLPSAESPAGRPDGGLG---GEAALQNCP
RPEIPP-KVMSLLVVPGSSDVKDKVSLDLPQIGPPLTSTPQLQAGGEPGDQGS-MQLDCK
GLEEGPAPVLPTG------------QGKPVAQGGLTDQSVLGAQTVPETVKVPMAAAVPK
AENPPRTPVPPAAPKVPTSRMMPA-VHTEPAAPEVPL-----------------------
-------------APTKP------TAQLMAT-VQKTVVNQPVL----AAQVEPTTPKTPQ
AQKMPV---AKTSTAGPKTPKAQAGPAATVSKAPAASKA------------PAAPKVPVT
PRVSRAPKT--------PAAQKVPTDAGPTLDVAKLLSEVQPTSRASVSLSKGQGQA-GR
QGPQPSGTLALSSKHQFQMEGLLGA-WEGAPRQPPRHLQ-----ANSTVTSFQRYHEALN
TPFELNLSGEPGNQGLRRVVIDGSSVAMVHGLQHFFSCRGIAMAVQFFWNRGHREV----
TVFVPTWQLKKNRRVRESHFLTKLHSLKMLSITPSQLENGKKITTYD-------YRFM-V
KLAEETDGIIVTNEQIHILMNNS-KKLM--VKDRL-------------------------
-LPFTFAGNL------FMVPDDPLGRDGPTLDEFLKKPNRLDTDIGNFLKV----WKTLP
PSSASVTELSDD-SDSGTLESLPNMEEVREEKEERQDE---E-----------Q------
--RQGQGT--------QKAA-EEDDLDSSLASVFRVECPSLSEEILRCLSLHDPPDGALD
IDLLPGAASPYLGIPWD--GKAPCQQVLAHLAQLTIPSNFTALSFFMGFMDSHRDAIPDY
EALVGPLHSLLKQKPDWQWDQEHEEAFLALKRALVSALCLMAPNSQLPFRLEVTVSHVAL
TAILHQEHSGRKHPIAYTSKPLLPDEESQGPQSGGDSPYAVAWALKHFSRCIGDTPVVLD
LSYASRTTADPEVREGRRVSKAWLIRWSLLVQDKGKRALELALLQGLLGENRLLTPA-AS
MPRFFQVLPPFSDLSTFVCIHMSGYCFYREDEWCAGFGLYVLSPTSPPVSLSFSCSPYTP
TYAHLAAVACGLERFGQSPLPVVFLTHCNWIFSLLWELLPLWRARGF-LSSDGAPLPHPS
LLSYIISLTSGLSSLPFIYRTSYRGSLFAVTVDTLAKQGAQGGGQWWSLPKDVPAP-TVS
PHAMGKRPNLLALQLSDSTLADIIARLQAGQKLSGSSPFSSAFNSLSLDKESGLLMFKGD
KKPRVWVVPTQLRRDLIFSVHDIPLGAHQRPEETYKKLRLLGWWPGMQEHVKDYCRSCLF
CIPRNLIGSELKVIESPW---P--LRS--TAPWSNLQMEVVGPVTISEEGHKHVLIVADP
NTRWVEAFPLKPYTHTAVAQVLLQHVFARWGVPVRLEAAQGPQFARHVLVSCGLALGAQV
ASLSRDLQFPCLTSSGAYWEFKRALKEFIFLHGKKWAASLPLLHLAFRASSTDATPFKVL
TGGESRLTEPLWWEMSSANIEGLKMDVFLLQLVGELLELHWRVADKASEK---AENRRFK
RESQEKEWNVGDQVLLLSLPRNGSSAKWVGPFYIGDRLSLSLYRIWGFPTPEKLGCIYPS
SLMKAFAKSGTPLSFKVLEQ----

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------EYLKGLCSPELQDEIHYPPKLHCIFLGAQGFF-LDCLAWSTSAH
----------L---VPRAPGSLMISGLTEAFVMAQSRIEELAERLSWDFTPGPSSGASQC
TGVLRDFSALLQSPGDAHREALLQLPLAVQEELLSLVQEASIGQGPGA----LASWE-GR
S----S-------GLLGAQC--Q----GVRAP-PSDG----RESLD------TGSMGPGD
SR------------------------------------------GAR--GDT--------
----------------------------------Y----AVE-EGGKQVGPREM----DL
GWKELPGE-------------------------------------EAWERE------VAL
R-----------PQSVGG----------------------------------GA-RES--
-----APL-KGKALGKEEIT----------------QGGGG-FCVHRE---PPGAHGSCH
RAA-----------------------------------------QSRGASLLQRLHN--G
NASPPRV-----------------------------------------------------
-------------PSPPPA-----------------------------------------
--------------PEPPWHCGDRGDCGDRGDVGDR------------------------
------------------------------------------------------------
------GDK----------QQG---------------MARGRG----P--Q---------
--------------------------WKRG------ARG-----G-NLVTGTQRFKEALQ
DPFTLCLANVPGQPDLRHIVIDGSNVAMVHGLQHYFSSRGIAIAVQYFWDRGHRDI----
TVFVPQWRFSKDAKVRESHFLQKLYSLSLLSLTPSRVMDGKRISSYD-------DRFM-V
KLAEETDGIIVSNDQFRDLAEESEKWMAIIRER---------------------------
LLPFTFVGNL------FMVPDDPLGRNGPTLDEFLKKPART-QGSS-KAQHPSRGFAEHG
----------------------------------KQQ-----------------------
---------------Q--G-REEEKGSGG--IRKTRETERLRRQLLEVFWGQDHKV---D
FIL---------------QREPYC-RDINQLSELLSLF----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
--------------------------------------------------------MLL-
--SGGDPPAQEWFMVQTKS-KPRVQRQRLQVQRIFRVKLNAFQ----------SRPDTPY
FWLQLEGPRENMGKAKEYLKGLCNPELWKEVRYPPILHCAFLGAQGLF-LDCLCWSTLAY
----------L---VPGPPGSLMVGGLTESFIMTQNWLEELVGRLRWGPAPLLTPRGIWE
AEVTRAFGALVWIRGDQHAGDLLQLPPAVQELLLSLVRDAAGKEDI-IEWLSRFGISDSH
---SDP-------EVLI-------------------------------------------
-CPSQQQKEAPAMVSVGESPG---PFVDMGTLQ-----NRVPEN--SKRLSSLGATGSLI
---------PAQSTPQ----------EAANQLVRVGSNSQ---GG-MDSAQEEGP---VQ
ATSSQDSTNHTQA--------LLKQKQVQRIEDK--LLFQP--PVSALGVCPSWKAWTPG
PA--------FGPLWPGA------IAATFWRIN---ELHS----LHLAWLLSQACFNFPF
WQ-RPLGPIQLKLPGQNPLPLNLEWKQKELAPLPSAESPAGRPDGGLG---GEAALQNCP
RPEIPP-KVTSLLVVPGSSDVKDKVSSDLPQIGPPLTSTPQLQAGGESGDQGS-MQLDCK
GLEEGPAPVLPAG------------QGKPMAQGGLTDQSVPGAQTVPETLKVPMAAAVPK
AENPPRTQVPPAAPKVPTSQMMPA-AHTEPAAPKVPS-----------------------
-------------APTKP------AAQMMAT-AQKTVVNQPVL----AAQVEPTTPKTPQ
AQKMPV---AKTSPAGPKTPKAQAGAAATVSKASAASKA------------PAAPKVPVT
PKVSRAPKT--------PAAQKVPMDAGPTLDVAKLLSEVQPTSRASASLPKGQGQA-GR
QGPQPSGTLALSSKHQFQMEGLLGA-WEGAPRQPPRHLQ-----ANNTVTSFQRYHEALN
TPFELNLSGEPGNQGLRRVVIDGSSVAMVHGLQHFFSCRGIAMAVQFFWNRGHREV----
TVFVPTWQLKKNRRVRESHFLTKLHSLKMLSITPSQLENGKKITTYD-------YRFM-V
KLAEETDGIIVTNEQIHILMNNS-KKLM--VKDRL-------------------------
-LPFTFAGNL------FMVPDDPLGRDGPTLDEFLKKPNRLDTDIGNFLKV----WKTLP
PSSASVTELSED-ADSGPLESPPNMEEVREEKEERQDE---E-----------Q------
--RQGRGM--------QKAA-EEDDLDSSLASVFRVECPSLSEEILRCLSLHDPPDGALD
IDLLPGAASPYLGIPWD--GQAPCQQVLAHLAQLTIPSNFTALSFFVGFMDSHRDAIPDY
EALVGPLHSLLKQKPDWQWDQEHEEAFLALKRALVSALCLTAPNSQLPFRLEVTVSHVAL
TAILHQEHSGRKHPIAYTSKPLLPDEESQGPQSGGDSPYAVAWALKHFSRCIGDTPVVLD
LSYASRTMVDPEVREGRRFSKAWLIRWSLLVQDKGKRALELALLQGLLGENRLLTPA-AS
MPRFFQVLPPFSDLSTFVCIHMSGYCFYREDEWCAGFGLYVLSPTSPPVSLSFSCSPYTP
TYAHLAAVACGLERFGQSPLPVVFLTHCNWIFSLLWELLPLWRARGF-LSSDGAPLPHPS
LLSYIISLTSGLSSLPFIYRTSYRGSLFAVTVDTLAKQGAQGGGQWWSLPKDVPAP-TVT
PHAMGKRPNLLALQLSDSTLADIIARLQAGQKLSGSSPFSSAFNSLSLDKESGLLMFKGD
KKPRVWVVPTQLRRDLIFSVHDIPLGAHQRPEETYKKLRLLGWWPGMQEHVRDYCRSCLF
CIPRNLIGSELKVIESPW---P--LRS--TAPWSNLQIEVVGPVTISEEGHKHVLIVADP
NTRWVEAFPLKPYTHTAVAQVLLQHVFARWGVPVRLEAAQGPQFARHVLVSCGLALGAQV
ASLSRDLQFPCLTSSGAYWEFKRALKEFIFLHGKKWAASLPLLHLAFRASSTDATPFKVL
TGGESRLTEPLWWEMSSANIEGLKMDVFLLQLIGELLELHWRVADKASEK---AENRRFK
RESQEKEWNVGDQVLLLSLPRNGSSAKWVGPFYIGDRLSLSLYRIWGFPTPEKLGCIYPS
SLMKAFAKSGTPLSFKVLEQ----

------------------------------------------------------------
--------------------------------------------------------MLL-
--SGGDPPAQEWFMVQTKS-KPRVQRQRLQVQRIFRVKLNAFQ----------SRPDTPY
FWLQLEGPRENMGKAKEYLKGLCNPELWKEVRYPPILHCAFLGAQGLF-LDCLCWSTLAY
----------L---VPGPPGSLMVGGLTESFVMTQNWLEELVGRLRWGPAPLLTPRGIWE
AEVTRAFGALVWIRGDQYAGDLLKLPPAVQELLLSLVRDAAGKEDI-IEWLSRFGISDTH
---SDP-------EVLI-------------------------------------------
-CPPLQQKEDPAVVTVGESPG---PLLEVGTLQ-----NGGPEK--SKRLTSLGATASLI
---------PAQSTQQ----------EATNQLVRVGSNNQ---NG-TDSTQEDGP---VQ
ATSGQDSANHTQA--------LFQKRKVPRVEDK--LPVQP--PVSALGVCPPWKAWTPG
PA--------FGPLWPGA------IAATFCRIN---ELHS----LHLAWLLSQACFSFSF
WQ-RSLAPIQLKLPGQTPLPLNLEWKQKELTPLPGAGSSACGPVRGLG---GEVALQNCP
RPETPS-KVMSLLVAPGGSGVKDKGSSGLPQIGPPLISTSQLQTTGEPGDQGS-MHLDCK
DLKERPSLAPPTGQGAPT------AQGKP-----MTTQSVPEAQTVPEMLKVPVATAVSK
AENPRPTQGLPAAPKVPTAQMMPA-VHTEPVAPKVPS-----------------------
-------------APTKPA------AHVVPT-AQKAAVGQLAS----AGQVVPTIPKTPT
AQKMPA---AKTSPASPKTLKSQTGPAAKTGST--------APK------APAAPKASAT
PKASRAPQM--------PAAQKGSIDAGAALEIAKLLSEVQLSSRGSASLPQGQGEAGGR
QGPQPSSTLALSSKHKSQMEGLLGAPWEGAPRQSPRHPQ-----ANSTVTSFQRYHEALN
TPFELNLSEEPGNQGLRRVIIDGSSVAMVHGLQHFFSCRGIAMAVQFFWNRGHREV----
TVFVPTWQLKKNRRVRESHFLTKLHSLKMLSITPSQLENGKKITTYD-------YRFM-V
KLAEETDGIIVTNEQIHILMNNS-KKLLV-KDR---------------------------
LLPFTFAGNL------FMVPDDPLGRDGPTLDEFLKKPNRLDIDIGNFLKV----WKTLP
LSSASASKLSDD-ADPEPLESPLKMEEVREKEERQDEE---------------Q------
--REGQGMQK---------LAEEDDLDSSLASVFGVECPSLSEEILQCLSLHDPADAALD
IDLLPVVASPHLGIPWD--GKAPCPQVLAHLAQLTVPSNFTALSFFVGFMDSHREVIPDY
EALVGPLHSLLKQKPDWQWGWEHEKAFLALKRALVSALCLTAPNPQLPFCLQVTVSQVAL
TAILHQEHSGRRHPIAYTSKPLLPDEESEGPQSGGDSPYAVAWALKHFSRCIGDTPVVLD
LSYASRTTVDPEAREGRRVSKAWLIRWSLLVQDKGKRALELTLLQGLLRENRLLMPA-SS
MPRFFQVLPPFSDLSTFICIHMSGYCFYREDEWCAGFGLYVLSPSSPPVSLSFSCSPYTP
TYAHLAAVACGLERFGQSQLPVVFLTHCNWIFSLLWELLPLWRARGF-LSSDGAPLPHPS
LLSYIITLTSGLSSPPFIYRTSYRGSLFAVTVDTLAKQGAQGGGQWWSLPKDVPVP-LVT
SHTMGRRPNLLALQLSDSTLADIIAKLHTGKKLPSSSPFSSAFNSLSLDKESGLLMFKGD
NTPMVWVVPRQLRRDLIFSVHDIPLGAHQRPEETYKKLRLLGWWPGMQEHVKYYCRSCLF
CIPRNLIGSELKVIESPW---P--LRS--TAPWSSLQIEVVGPVTVSEEGHKHVLIVADP
NTRWVEAFPLKPYTHKAVAQVLLQHVFARWGVPMRLEAAQGPQFARHVLVSCGLALGAQV
TSLSKNLQFSCLTSSDAYWEFKRALKEFIFLHGKKWATSLPLLHLAFRASSTEATPFRVL
TGGEVRLAEPLWWEISSANIEGLKMDIFLLQLVRELLELHWRVADKADEK---TENRCFK
RESQEKEWNVGDQVLLLSLPRNGSSAKWVGPFYIGDRLSLSLYRVWGFPTPEKLGCIYPS
SLMKAFAKSGTPLSFKVLEQ----

------------------------------------------------------------
--------------------------------------------------------MSTW
-GFASP--TPDRFAVSAEA-EAKVREQQACLERIFNVGMSVLS---------KDCPENPH
IWLQLEGPKENVCRAKEYLKGLCSPELQSEIHYPPRLHCIFLGAQGFF-LDCLAWSTSAH
----------L---VPLLPGSLMISGLTEAFVMAQSRVEELVQRLSWDLQLQSCPGAPDN
GGVLRDFLALLQTRKDAYTEALLQLPLAVQEELLSLVQEASRGQGP--------SRE-VG
S----P-------GLLSPQF--Q----GVRAP-LNEG----RESVG------TGVAGSGK
SR------------------------------------------AVR--GQS--------
----------------------------------H----TVEKEERKQDAVRDM----GS
GRKELSGE-------------------------------------EVWEPG------VAY
R-----------SQLADG----------------------------------GA-EE---
-----VASLKGKALGKQEVP----------------QQRGG-FSVQGE---SSGAHVPCQ
RAA-----------------------------------------PTRGASLLQRLHN--G
STSPPRV-----------------------------------------------------
-------------PSPPPA-----------------------------------------
--------------PEPPWPCGDRDR--DRD-RGDR------------------------
------------------------------------------------------------
------GDK----------QQA---------------GARGRG----S--P---------
--------------------------WKRG------TRG-----G-NLVTGTQRFQEALQ
DPFTLCLANVPGQPDLRHIVIDGSNVAMVHGLQHYFSSRGIALAVQYFWDRGHRDI----
TVFVPQWRFSKDSKVRESHFLQKLYSLSLLSLTPSRVMDGKRISSYD-------DRFM-V
KLAEETDGIIVSNDQFRDLAEESDKWMAIIRER---------------------------
LLPFTFVGNL------FMVPDDPLGRNGPTLDEFLKKPVRK-QGSS-KSQQPSKGSTEHA
----------------------------------NQQ-----------------------
--------------QGKEV---E-RSNGG--IRKTRETERLRRQLLEVFWGQDHKV---D
FIL---------------QREPYC-RDINQLSEALLSLNF--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
--------------------------------------------------------MPTW
-GAGSP--SPDRFAVSAEA-EDKVREQQHYVERIFRVGMSVLP---------KDCPENPH
IWLQLEGPKENASRAKEFLKGLCSPELQDEVHYPPKLHCIFLGAQGFF-LDCLVWSTTAH
----------L---VPGPPGSLMVSGLTEAFVMAQSRVEELVERLSWDFRPGRAPGASQG
AGVLRDFSALLQPCGDAHREALLQLPPAVQEELLSLVREASRGQGPHA----PPLWD-RG
S----P-------GPLGAQY--Q----GVRAP-LSED----RESVD------PGPMGWRE
SR------------------------------------------GE-----R--------
----------------------------------H----VMEKEGGKQGPPRAM----DL
GWKELPGE-------------------------------------GAWEKE------GAF
R-----------SQSEG----------------------------------GVP-GQV--
-----GPL-TAKALGQEGMP----------------QDRGSSFCVQGE---PSGAQGPYQ
RAA-----------------------------------------QPRGASLLQRLHN--G
RASPPRV-----------------------------------------------------
-------------PSPPPA-----------------------------------------
--------------PEPPWHCGDRGD---------R------------------------
------------------------------------------------------------
------GDK----------QQV---------------VARGRG----S--P---------
--------------------------WKRG------TRG-----G-NLVTGTQ-FQEALQ
DPFTLCLANVPGQPDLRHIVIDGSNVAMVHGLQHYFSSRGIAIAVQYFWDRGHRDI----
TVFVPQWRFSKDAKVREGHFLQKLYSLSLLSLTPSRVMDGKRISSYD-------DRFM-V
KLAEETDGVIVSNDQFRDLAEESEKWMAIIRER---------------------------
LLPFTFVGNL------FMVPDDPLGRNGPTLDEFLKKPVRA-QGAS-KAQHPSRGFTDHG
----------------------------------QQQ-----------------------
--------------QQ--GREEEEKGSGG--IRKTRETERLRRQLLEVFWGQDHKV---D
FIL---------------QREPYC-RDINQLSEALLSLNF--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
--------------------------------------------------------MLL-
--SGGDPPAQEWFMVQTKS-KPRVQRQRLQVQRIFRVKLNAFQ----------SRPDTPY
FWLQLEGPRENMGKAKEYLKGLCSPELWKEVRYPPILHCAFLGAQGLF-LDCLCWSTLAY
----------L---VPGPPGSLMVGGLTESFIMTQNWLEELVGRLRWGPAPLLTPRGIWE
AEVTRAFGALVWIRGDQHAGDLLQLPPAVQELLLSLVRDAAGKEDI-IEWLSRFGISDSH
---SDP-------EVLI-------------------------------------------
-CPPQQQKEAPAMVSVGESPG---PFVDMGTLQ-----NRGPEN--SKRLSSLGATGSLI
---------PAQSTPQ----------EAANQLVRVGSNNQ---DG-MDSAQEEGP---VQ
ATSSQDSTNHTQA--------LLKQRQVQKIEDK--LLFQP--PVSALGVCPPWKAWTPG
PA--------FGPLWPGA------IAATFWRIN---ELHS----LHLAWLLSQACFNFPF
WQ-RPLGPIQLKLPGQNPLPLNLEWKQKELAPLPSAESPAGRPDGGLG---GEAALQNCP
RPEISP-EVTSLVVVPGSSDVKDKVSSDLPQIGPPLTSTPQLQAGGEPGDQGS-MQLDFK
GLEEGPAPVLPTG------------QGKPVAQGGLTDRSVPGAQTVPETLKVPMAAAVPK
AENPPRTQVPSAAPKVPTSRMMLA-VHTEPAAPEVPL-----------------------
-------------APTKP------TAQLMAT-AQKTVVNQPVL----AAQVEPTTPKTPQ
AQKMPV---AKTSPAGPKTPKAQAGPAATVSKAPAASKS------------PAAPKVPVT
PRVTRAPKT--------PAAQKVPTDAGPTLDVAKLLSEVQPTSRASVSLLKGQGQA-GR
QGPQSSGTLALSSKHQFQMEGLLGA-WEGAPRQPPRHLQ-----ANSTVTSFQRYHEALN
TPFELNLSGEPGNQGLRRVVIDGSSVAMVHGLQHFFSCRGIAMAVQFFWNRGHREV----
TVFVPTWQLKKNRRVRESHFLTKLHSLKMLSITPSQLENGKKITTYD-------YRFM-V
KLAEETDGIIVTNEQIHILMNNS-KKLM--VKDRLEPFLLLGCQAAPGMGEIRAGREALD
LLPFTFAGNL------FMVPDDPLGRDGPTLDEFLKKPNRLDTDIGNFLKV----WKTLP
PSSASVIELSDD-ADSGPLESLPNMEEVREEKEERQDE---E-----------Q------
--RQGQGT--------QKAA-EEDDLDSSLASVFRVECPSLSEEILRCLSLHDPPDGALD
IDLLPGAASPYLGIPWD--GKAPCQQVLAHLAQLTIPSNFTALSFFMGFMDSHRDAIPDY
EALVGPLHSLLKQKPDWQWDQEHEEAFLALKRALVSALCLMAPNSQLPFRLEVTVSHVAL
TAILHQEHSGRKHPIAYTSKPLLPDEESQGPQSGGDSPYAVAWALKHFSRCIGDTPVVLD
LSYASRTTADPEVQEGRRVSKAWLIRWSLLVQDKGKRALELALLQGLLGENRLLTPA-AS
MPRFFQVLPPFSDLSTFVCIHMSGYCFYREDEWCAGFGLYVLSPTSPPVSLSFSCSPYTP
TYAHLAAVACGLERFGQSPLPVVFLTHCNWIFSLLWELLPLWRARGF-LSSDGAPLPHPS
LLSYIISLTSGLSSLPFIYRTSYRGSLFAVTVDTLAKQGAQGGGQWWSLPKDVPAP-TVS
PHAMGKRPNLLALQLSDSTLADIIARLQAGQKLSGSSPFSSAFNSLSLDKESGLLMFKGD
KKPRVWVVPTQLRRDLIFSVHDIPLGAHQRPEETYKKLRLLGWWPGMQEHVKDYCRSCLF
CIPRNLIGSELKVIESPW---P--LRS--TAPWSNLQIEVVGPVTISEEGHKHVLIVADP
NTRWVEAFPLKPYTHTAVAQVLLQHVFARWGVPVRLEAAQGPQFARHVLVSCGLALGAQV
ASLSRDLQFPCLTSSGAYWEFKRALKEFIFLHGKKWAASLPLLHLAFRASSTDATPFKVL
TGGESRLTEPLWWEMSSANIEGLKMDVFLLQLVGELLELHWRVADKVSEK---AENRRFK
RESQEKEWNVGDQVLLLSLPRNGSSAKWVGPFYIGDRLSLSLYRIWGFPTPEKLGCIYPS
SLMKAFAKSGTPLSFKVLEQ----

------------------------------------------------------------
--------------------------------------------------------MPTW
-EARPA--SPDRFAVSAEA-ETKVREQQPHVQRIFSVGVSVLP---------KDCLDNPH
IWLQLEGPKENASRAKEYLKGLCSPELQDEIHYPPKLHCIFLGAQGFF-LDCLTWSTSAH
----------L---VPREPGSLMISGLTEAFVMAQSRVEELVERLSWDFLPGPSPGASQC
PGVLRDFSALLHSPGDAHREALLQLPLAVQEELLSLVQEASSGQGPGA----LTSWE-GR
S----S-------GLLGAQC--Q----GVRAP-PSDG----SESLD------TGSVGPIE
SR------------------------------------------GAR--GDG--------
----------------------------------Y----AVE-KGGKQGGPREM----AF
GWKELPGE-------------------------------------EAWERE------VGL
R-----------PQSVGR----------------------------------GA-RES--
-----APL-KGKTLGKEEAT----------------QGGGG-VCVHRE---SPSAHGSCH
RTA-----------------------------------------QSRGASLLQRLHN--G
NASPPRV-----------------------------------------------------
-------------PSPPPA-----------------------------------------
--------------PEPPWHCGDRGDWGD---GGDR------------------------
------------------------------------------------------------
------GDK----------QQA---------------TARGRG----P--H---------
--------------------------WKRG------ARG-----G-NLVTGTQRFKEALQ
DPFTLCLANVPGQPDLRHIVIDGSNVAMVHGLQHYFSSRGIAIAVQYFWDRGHRDI----
TVFVPQWRFSKDAKVRESHFLQKLHSLSLLSLTPSRVMDGKRISSYD-------DRFM-V
RLAEEKDGIIVSNDQFRDLAEESENWMAIIRER---------------------------
LLPFTFVGNL------FMVPDDPLGRNGPTLDEFLKKPART-QGPS-KAQHPSRGFAEHG
----------------------------------KQQ-----------------------
---------------Q--G-REEEKGSGG--IRKTRETERLRRQLLEVG-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
--------------------------------------------------------MPTS
-G-----RTLDEFAVSEEA-QEVVTQHRPRIEQLFGVELNVLGVLGLDQGPGGDFPGARK
IWLQLQGHGDNLQRAKEYIKGLCAPELTEEVYYPKDMQCIFLGAHGLF-LNCLTQGTSAH
----------I---TCLRPGVLLISGLAEAFVMAQSRIQEFVEKHQKNLKLP----EEWE
AQVKRAFRDLVETYDDKHAMDLLILPTSVKEELLNLVKENQEDRQG--------KWETVT
LGGGRPQSPKRPQNTFGLP---M----GLTTI-REES-----RNRDCSVELPAGFTRLQE
SPP----------------------KS-HDFTQPQCSGRHRNVRTDP--GQALPQG----
-S--------------------RVDFP----R--G----VAESEDKQEEGKSSL-CARDS
SPASLPEETSEE-------------------------EVSSDIQLSSWTEKEFKMRLNFF
KTMGYEERVVKKILLEGG-VR-EAPSTILDKVHMAEAGQKGDLILP--QIEPGG-KEF--
-----PPPLPGKTQDEKDYM----------------RE---------I---IRAAVANCG
HSPSEI---------STEIHT-----------------------GAPLADILRRLHE--K
GEEPEGATGT-----------------------------------------------SAM
KPEQGGQPGVRRATVLNHK-----------------------------------------
--------------EPSPWRPDNDTRRNSGSPFHEEHHTSP-------------------
--------------PNP--------------------------------AVVAFSPDI--
PS---TGNF----------LSS------TSD------SEENHS----S--E---------
-------------------------STSFG------HHG-----PVSTVTGAQRFEEALQ
MQFKLKLANTPGKKNLRMVIIDGSNVAMMHGLNQFFSCRGIALAVQYFWDRGHREV----
TVLVPQHRMEEDSNVREKHYLVELHKLSILSLTPSRKIDGKGIVPYD-------DRFM-L
KLAEQTNGVIVTNDQFRDLAKESKKWIRIIKES---------------------------
LLQYIFVGNI------FMVPDDPLGREGPTLVEFLKKNPRLRSTAINIGTAPSYGCKTKA
PSCHSFSGRPARAP----------------VPVRPTSQTEVL----------------HL
RDRK---PPAVLLGDRRRDPQDTATEKEA--LRLDTETERLRRDLLEIFVDQDRKV---D
FVL---------------MREPCC-RDLNKLSEALLSLTF--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
--------------------------------------------------------MPTW
-GARPA--SPDRFAVTAEA-ENKVREQQPHVERIFSVGVSVLP---------KDCPDNPH
IWLQLEGPKENASRAKEYLKGLCSPELQDEIHYPPKLHCIFLGAQGFF-LDCLAWSTSAH
----------L---VPRAPGSLMISGLTEAFVMAQSRVEELAERLSWDFTPGPSSGASQC
TGVLRDFSALLRSPGDAHREALLQLPLAVQEELLSLVQEASSGQGPGA----LASWE-GR
S----S-------ALLGAQC--Q----GVRAP-PSDG----RESLD------TGSMGPGD
SR------------------------------------------GAR--GDT--------
----------------------------------Y----AVEKEGGKQGGPREM----DL
GWKELPGE-------------------------------------EAWERE------VAL
R-----------PQSVGG----------------------------------GA-RES--
-----APL-KGKALGKEEIT----------------LGGGG-FCVHRE---PPGAHGSCH
RAA-----------------------------------------QSRGASLLQRLHN--G
NASPPRV-----------------------------------------------------
-------------PSPPPA-----------------------------------------
--------------PEPPWHCGDRGDCGDRGDVGDR------------------------
------------------------------------------------------------
------GDK----------QQG---------------MARGRG----P--Q---------
--------------------------WKRG------ARG-----G-NLVTGTQRFKEALQ
DPFTLCLANVPGQPDLRHIVIDGSNVAMVHGLQHYFSSRGIAIAVQYFWDRGHRDI----
TVFVPQWRFSKDAKVRESHFLQKLYSLSLLSLTPSRVMDGKRISSYD-------DRFM-V
KLAEETDGIIVSNDQFRDLAEESEKWMAIIRER---------------------------
LLPFTFVGNL------FMVPDDPLGRNGPTLDEFLKKPART-QGSS-KAQHPSRGFAEHG
----------------------------------KQQ-----------------------
---------------Q--G-REEEKGSGG--IRKTRETERLRRQLLEVFWGQDHKV---D
FIL---------------QREPYC-RDINQLSEALLSLNF--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
--------------------------------------------------------MPTW
-GAGSP--SPDRFAVSAEA-EDKVREQQPYVERIFSVGMSVLP---------KDCPENPH
IWLQLEGPKENASRAKEFLKGLCSPELQDEVHYPPKLHCIFLGAQGFF-LDCLVWSTSAH
----------L---VPGPPGSLMVSGLTEAFVMAQSRVEELVERLSWDFQPGRSPGALQC
AGVLGDFSALLQPYRDAHTQALLRLPLAVQEELLSLVQDATRDQGPQP----QPPCG-RG
N----P-------GPLDAQY--Q----GVRAP-SSEG----RESLD------PGPMGWQE
SR------------------------------------------GE-----R--------
----------------------------------Q----VMEKEGEKQGGPREM----EV
GWKELPGK-------------------------------------EAWEKA------GAF
R-----------SQSGG----------------------------------GVV-GQL--
-----GPFLTGKALGKEGVP----------------QDRGRSVGVQGE---PPIAQGPCQ
RAA-----------------------------------------QPRGASLLQRLHN--G
KASPPRV-----------------------------------------------------
-------------PSPPPA-----------------------------------------
--------------PEPPWHCGDRGDRGDR---GDR------------------------
------------------------------------------------------------
------GDK----------QQV---------------VARGRG----S--P---------
--------------------------WKRG------TRG-----G-NLVTGTQRFQEALQ
DPFTLCLANVPGQPDLRHIVIDGSNVAMVHGLQHYFSSRGIAIAVQYFWDRGHRDI----
TVFVPQWRFSKDARVREGHFLQKLYSLSLLSLTPSRVMDGKRISSYD-------DRFM-V
KLAEETDGVIVSNDQFRDLAEESEKWMAIIRER---------------------------
LLPFTFVGNL------FMVPDDPLGRNGPTLDEFLKKPVRA-QGSS-KVQHPSRGFAEPG
----------------------------------QQQ-----------------------
---------------Q--GREEEEK-GSG--IRKTRETERLRRQLLEVFWGQDHKV---D
FIL---------------QREPYC-RDINQLSEALLSLNF--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
--------------------------------------------------------MR--
-----GREPPGRFTVPAEA-EDSVLELRPHVERIFRVQLSVLG---------EPEPGAPS
IWLQLEGPQENVGRAKEYVKGLCSPELWEEVNYPPALHCVFLGACSLF-LDCLCWGTSAH
----------M---VPQAPGSLLLGGLAEAFFMAQNRVEGLTKRLGWDPLPPPKSLRVPE
AEVNKAFRALLVGREDEHCGALLRLPLAVQEELLRLVQEAVKDGGD-AEWMGLRTPPLDG
S--SRPRPG-----RIS-----AKPLLELRALQQ---------GQFCGSRGEPGTVSQTE
DRQGHVIREGMTVLELGGRNRGKRVYREIPNLIPNCRGNKRPVNSPSFREEMLGLIRQVL
GDGLSPLTLTGPPTGTSASKAQGSHKPSSEPRIRWGDSSSKRKEDPHGRSSEEGS---EQ
SRVGLSSENYTKLRSSQIREVGVAQKQFHNLETKAAFKSQATIPFASWKTVSFPGTWGQG
SP--------CRPLWLGP-QHCAVGHSTFWRVQ---DGHS----SSLPWGLDWG-RSLPH
SQPRQATPLKFKVQAQSPIPVRLEWKNRPLLRDPILVSPSCNPGWWQV---LKTVPQMCQ
RPVTLI---------PGGYDVCSG----------------SLQRGTLVGDWEPGLLP--T
GIHEPRLVTT-------------------------------------------------F
GEQGPVQELVSPFPEMSLA-----------------------------------------
--------------------RAEI----LTDIIRDVSCGQP-------------------
--------------FGP--------------------------------VPVSLLKYFGE
PERQRQANC----------QPIHCFASAPVF------REKRKK----SKCP---------
------------------------KIVSSDQHVPFVHPQ-----VNNLVTSFQRFHEALS
VPFTLSLENIPGKPGLRHIIIDGSNVAMVHGLQHFFSCRGIALAVQYFWDRGHREI----
TVFVPNWRLRKNSRVREGHYLTKLHSLSLLSITPSRFVDGKRVTSYD-------DRFM-V
KLSEETDGVIVTNDQFRDLVDESKKWIGIIRER---------------------------
LLPFTFVGNI------FMVPDDPLGRDGPTLDTFLRRTDGLELAVSNFLKV----WETKP
PSKASFLPIKAKGL--------QGKKHLKRGCSGPQQKGKVK----------------KL
TE-----------GVEKLMVKEEDALDACLSTVFQEECPFLSDDILRYFSLQDNTS---E
TSLSPWRGSSQLDVPWGGAGQPTCQRVLDHLAQLSVPTSFSALSFFVGFMGCHKDVIPRY
SSLVAPLHGLLKKKTQWQWTPEHSQAFLALKQALVSALSLVPPDPQLPYRLEVAVSERTL
AAVLTQERAGLRRPIAYTSKALLPQEGKATLS-RGGGLCALAWAVRRFAPSLGSVPVVLE
ASYTSGDSAGPEQRESLDTSDTWLARWSLLVQDKDRRTLGTSFLPGPLGDSGLPMPTPDS
LPQFFQILPPFSDLSSFVCIYTSGYCFYQDTEWCAGFGLYVLSPDSPPLSLSFSCSPHTP
TYAHLAAVACGLERFVHSCIPLVFLVNCSWLFNILIDLLPLWHSRGF-LSSDGAPLPHPA
LLSYITSLASSLPTLPFLFKASYKGALFSVTVEALAKQGAQGSGPLWKLPRHIMPSVGVA
ASPLGGGPNLQALQENDAILLEAICQLQAGCRLPGHSPLKPFEPGISFVKECNLLMYGEM
KRPKVWVVPEQIRKDLIYSVHDVPPGPHADPEETLRRVRMLGWWPKMYGQVRAYCKCCLF
CTSINNLSKESKCMRTQWPSTP-------AVPWSNLQIDVIGPVPASEEGHRHVLIVADS
CSSWTEAFPLKSFTQMAVAQVLLQQVFSRWGLPSRLEAAQGAQFARHVLMSCGLVLGAKL
GSISGDIQPAELRDGNSNQAFKNLLKEFIILHGKNWASCLPLLHMAFRALESGPTPFAVV
TGSEMRLAESLWWELSGAHVEGLKMDVFLQQLKNNIIESQLQAAVASGDQSAMAQSSYLQ
QEVQGKEWNVGDQVLLLNFPKPG-TARWVGPYYIVDRLSLSLYRVWGYPTPGKLGVTYPT
NLMRSYPQGGAPLPSVILEQLE--

------------------------------------------------------------
--------------------------------------------------------MLL-
--SGGEPPALEWFMVQTKS-KPRVQRQRLQVQRIFRVKLNAFR----------SRPDTPY
FWLQLEGPRENTSKAKEYLKGLCSPELWKEVRYPPMLHCAFLGAQGLF-LDCLCWSTLAY
----------L---VPGPPGSLMVGGLTESFTMTQNWLEELVARLHWGPAPLLTPRGIWE
AEVTRAFGALVWIRGDQYAGDLLQLPPAVQELLLSLVRDAAGKEDI-IEWLSHFGISSTC
---AGP-------EVLI-------------------------------------------
-SPPQQQKEDSAVVSTGDSPG---PFLEMGTFQ-----IEGPEN--PKRVNSLGATKSLI
---------PFQNTLQ----------GTTKQLVRVSSNNQ---SG-TDSAQEEGL---VQ
TSSSQDSPNHTPA--------LLQQKQVQKV-EK--FLFKP--PVSALGVCPSWKAWAPG
PA--------FGPLWPGT------IAAAFWRIN---ELHS----LHLAWLLSQACFSLPF
WQ-RPLGPVQLKLPGQSALPLNLEWKQKELTPLPSTEGPACRPDGQLG---GEATLQTCP
RPETPPSKVMSLFVVPGGSGEKDKVSSGRL----HTAST--AQAGDKRGNQGG-VQKDCK
WLVKGPSPVPPTGQGAP------TAQGRPMSA--------PGVQTVPETLKVPMAAAVPK
AENPAIAERQPAAPKVPLAPT---------------------------------------
----------------KP------TVPVEST-APK----------AAATQVTTTVPKTAM
SQKMPA---AKTSPADPQTLKAHSGVL---------------------------------
-------RT--------SAVQKVPTGEGPTLDVARLLSEAQPLSRGDASSPKGQGEP-GR
QCAQPSS-----SKHQLQAEGLLKD-WEGGPRQSPRHPQ-----ANSIVTSFQRYHEALN
TPFELNLSGEPGNQELRRVVIDGSSVAMVHGLQHFFSCRGIAMAVQYFWNRGHREV----
TVFVPTWQLKKNRRVRESHFLTKLHSLKMLSITPSQLENGKKIATYD-------YRFM-V
KLAEETDGIIVTNEQIHTLMNNSSKKLMV-KDR---------------------------
LLPFTFAGNL------FMVPDDPLGRDGPTLDEFLKKPNRLDTDVGNFLKV----WKTLP
PSSASVSELSNG-PDPRPLEGPQYVEEAREKKEERQNEEWR-------------------
---EGQG---------TLEWAEEDDLDSSLASVFRVECPSLSEEILQCLSLHDPPDGALD
IDLLPGVASPHLGIPWD--GKAPCQQVLAQLAQLTTPSNFTVLSFFVGFMDSHQDVIPDY
EALMGPLHSLLKQKPDWQWDQEHEKAFLSLKRALVSALCLAAPNSQLPFRLQVTVSQVAL
TAILSQEHSGRRHPIAYTSKPLLPDEDSEGPQSGGDSPYAVAWALKHFSRCIGDTPVVLD
LSYASRPTVTSEAPEGRRLPKAWLIRWSLLVQDRGKRTLELALLQGLLRENQLLTPA-SA
MPRFFQVLPPFSDLSTFVCIHMSGYCFYREDEWCAGFGLYVLSPTSPPVSLSFSCSPHTP
TYAHLAAVACGLERFGQSHLPVVFLTHCNWIYSLLWELLPLWRARGF-LSSDGAPLPHPS
LLSYIISLTSGLSSLPFIYRTSYRGSLFAVTVDNLAKQGAQGGGQWWNLPKDVPVP-VVI
PQAVGKRPNLLALQLSDSTLADIIAKLRAGQKLSGSSPFSSAFNSLSLDRESGVLMFKGD
KKPKVWVVPRQLRRDLIFSVHDIPMGAHQRPEETYKKLRFLGWWPGMQEHVKDYCRSCLF
CIPRNVIGNELKVIESPW---P--LRS--TAPWSNLQIEVVGPVTISEEGHRHVLIVADP
NTRWVEAFPLKPYTHMAVAQVLLQHVFARWGVPVRLEAAQGPQFARHVLVSCGLALGAQV
TCLSRDLQFPGLVSSEVYWEFKRALKEFIFLHGKKWVASLPLLHLAFRAASTVATPFQVL
TGGERRLNEPLWWEMSSANIEGLQMDGFLLQLTQELLELHWRAAEKGTEK---ADNRRFK
RESQEKEWNVGDQVLLLSLPRNGSSAKWVGPFYIGDRLSLSLYRVWGFPTPEKLGCIYPS
SLMKAFAKSGTPLSFKALEQ----

------------------------------------------------------------
--------------------------------------------------------MLL-
--SGGDPPAQEWFMVQTKS-KPRVQRQRLQVQRIFRVKLSAFQ----------SRPDTPY
FWLQLEGPRENMGKAKEYLKGLCSPELWKEVRYPPILHCAFLGAQGLF-LDCLCWSTLAY
----------L---VPGPPGSLMVGGLTESFIMTQNWLEELVGRLRWGPAPLLTPRGIWE
AEVTRAFGALVWIRGDQHAGDLLQLPPAVQELLLSLVRDAAGKEDI-IEWLSRFGISDSH
---SDP-------EVLI-------------------------------------------
-CPPQQQKEAPAMVSVGESPG---PFLDMGTLQ-----NRGPEN--SKRLSSLGATGSLI
---------PAQSTPQ----------ETANQLVRVISSNQ---GG-MDSAREEGS---VQ
ATSSQDSTNYTQA--------LLQQRQVQRVEDK--LLFQP--PVSALGVCPPWKAWTPG
TA--------FGPLWPGA------IAATFWRIN---ELHS----LHLAWLLSQACFNFPF
WQ-RPLGPIQLKLPGQNPLPLNLEWKQKELAPLPSAESPAGRPDGGLG---GEAVLQNCP
RPETPP-KVMSLLVVPGSSDVKDKVSLDLPQIGPPITSTPQLQAGGEPGDQGS-TQTDCK
GLEEGPAAVLPAG------------KQKPMAQGGLTDHSVPGPQTVPETLKVPMAAAVLK
AENPPRTKVPPAAPKVPTSQMMLA-VHTEPAAPKVPL-----------------------
-------------APTKP------AAQLMAT-AQKTFVNQPVL----AAQVEPTTTKTPQ
AQKMPV---AKTSPSGPKTPKAQIGPAATASKAPAAPK------------TPTAPKVPVA
LKVSKAPKT--------LAAQKLPTDAGPTLDVAKLLSEVQPTSRASASLLKGQGQA-GR
QGPQPSGTLAISSKHHFQMEGLLGA-WEGAPRQPPRHLQ-----ANSTVTSFQRYHEALN
TPFELNLSGEPGNQGLRRVVIDGSSVAMVHGLQHFFSCRGIAMAVQFFWNRGHREV----
TVFVPTWQLKKNRRVRESHFLTKLHSLKMLSITPSQLENGKKITTYD-------YRFM-V
KLAEETDGIIVTNEQIHILMNNS-KKLMV-K-DR--------------------------
LLPFTFAGNL------FMVPDDPLGRDGPTLDEFLKKPNRLDTDIGNFLKV----WKTLP
PSSASVTELSDD-TDSGPLESLPNVEEVREEKEERQDE---E-----------H------
--RQGQGT--------QKLA-EEDDLDSSLASVFRVECPSLSEEILRCLSLHDPPDGALD
IDLLPGAASPYLGIPWD--GKAPCQQVLAHLAQLTIPSNFTALSFFVGFMDSHRDAIPDY
EALVGPLHSLLKQKPDWQWHQEHEEAFLALKRALVSALCLTAPNSQLPFRLEVTVSHMAL
TAILHQEHSGRKHPIAYTSKPLLPDEESQGPQSGGDSPYAVAWALKHFSRCIGDTPVVLD
LSYASRTTADPEVRDSRRVSKAWLIRWSLLVQDKGKRALELSLLQGLLGENRLLTPA-AS
MPRFFQVLPPFSDLSTFVCIHMSGYCFYREDEWCAGFGLYVLSPTSPPVSLSFSCSPYTP
TYAHLAAVACGLERFGQSPLPVVFLTHCNWIFSLLWELLPLWRARGF-LSSDGAPLPHPS
LLSYIISLTSGLSSLPFIYRTSYRGSLFAVTVDTLAKQGAQGGGQWWSLPKDVPVP-VVT
PHAMGKRPNLLALQLSDSTLAEIIARLQAGQKLSGSSPFSSAFNSLSLDKESGLLMFKGD
KKPKVWVVPTQLRRDLIFSVHDIPLGAHQRPEETYKKLRLLGWWPGMQEHVRDYCRSCLF
CIPRNLIGSELKVIESPW---P--LRS--TAPWSNLQIEVVGPVTISEEGHKHVLIVADP
NTRWVEAFPLKPYTHTAVAQVLLQHVFARWGVPVRLEAAQGPQFARHVLVSCGLALGAQV
ASLSRDLQFPCLTSSGAYWEFKRALKEFIFLHGKKWAASLPLLHLAFRASSTDATPFKVL
TGAEARLTEPLWWEMSSANIEGLKMDVFLLQLVGDLLELHWRVADKASEK---AENRRFK
RESQEKEWNVGDQVLLLSLPRNGSSAKWVGPFYIGDRLSLSLYRIWGFPTPEKLGCIYPS
SLMKTFAKSGTPLSFKVLEQ----

MSGQSHRPHSPGPGEA-DPAEWALRGCRWLSAGGA-SPRAAPPGPPAAARPGSQTTRHSP
SSRMGSAASWAHPAPRNKSIRAKGSMGLARGPAGWPCFAPSMSEWPGDPPGLGKAAMPTW
-GAGSP--SPDRFAVSAGA-EVKVREQQPHLERIFSVGMSVLS---------KDCPENPH
IWLQLEGPKENTSRAKEYLKGLCSPELQDEIHYPPKLHCIFLGAQGFF-LDCLTWSTSAH
----------L---VPGAPGSVMISGLTEAFVMAQSRVEELAERLSWDLQPGPSLGAS--
-EVLGDFSALLQSRGDTHREALLQLPLAVQEELLSLVQEASRGQGLKV----LSSWE-GR
S----P-------GLLGAQH--L----GVRAA-LNEG----RESQD------TGSGGWGE
SR------------------------------------------GG-----R--------
----------------------------------H----GMEKEAGKQGGPREM----DL
GWKELPGE-------------------------------------DTWERG------VAF
R-----------PELGG----------------------------------REL-GEA--
-----GPP-KGKVLEKEGVI----------------QQRGG-VYVQGE---PPSAHGPSQ
RAS-----------------------------------------QPRGASLLQRLHN--G
KASPPRV-----------------------------------------------------
-------------PSPPPA-----------------------------------------
--------------PEPPWHHGDRGDK---------------------------------
------------------------------------------------------------
------GDK----------QQT---------------VARGRG----S--P---------
--------------------------WKRG------TRG-----S-NLVTGTQRFQEALQ
DPFTLCLANVPGQPDLRHIVIDGSNVAMVHGLQHYFSSRGIAIAVQYFWDRGHRDI----
TVFVPQWRFSKDARVREGHFLQKLYSLSLLSLTPSRVMDGKRISSYD-------DRFM-V
KLAEETDGIIVSNDQFRDLAEESKKWMAIIRER---------------------------
LLPFTFVGNL------FMVPDDPLGRNGPTLDEFLKKPVRT-QESS-EAQHLPRGFAEHG
----------------------------------KE------------------------
--------------QQ--EREEEEKGSGG--IRKTRETERLRRQLLEVFWGQDHKV---D
FIL---------------QREPYC-RDINQLSEALLSLNF--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
----------------------------------------------MDPGLGGQAAMPTW
-GAGSP--SPDRFAVSAEA-EDKVREQQPYVERIFSVGMSVLP---------KDCPENPH
IWLQLEGPKENASRAKEFLKGLCSPELQNEIHYPPKLHCIFLGAQGFF-LDCLVWSTSAH
----------L---VPGLPGSLMVSGLTEAFVMAQSRVEELVERLSWDFQPGRSPRVSQC
AGVLRDFSALLQPYGDAHREALLQLPLAVQEELLSLVQEASRGQGPHA----IPPWV-GG
S----P-------GPLGAQY--Q----GVRAL-SSEG----RESLH------TGPARWQE
SR------------------------------------------GE-----R--------
----------------------------------H----VMEKEGGKQGGPREM----DL
GWKELPGQ-------------------------------------EAWEKE------GAF
R-----------SQPGG----------------------------------GEA-GQV--
-----GPL-TGKGLGKEGVP----------------QDRGR-FCVQSE---PPGAQGPYP
RAA-----------------------------------------QPRGASLLQRLHN--G
KASPPRV-----------------------------------------------------
-------------PSPPPA-----------------------------------------
--------------PEPPWHCGDRGD---------R------------------------
------------------------------------------------------------
------GDK----------QQV---------------VARGRG----S--P---------
--------------------------WKRG------TRG-----G-NLVTGTQRFQEALQ
DPFTLCLANVPGQPDLRHIVIDGSNVAMVHGLQHYFSSRGIAIAVQYFWDRGHRDI----
TVFVPQWRFSKDAKVREGHFLQKLYSLSLLSLTPSRVMDGKRISSYD-------DRFM-V
KLAEETDGVIVSNDQFRDLAEESEKWMAIIRER---------------------------
LLPFTFVGNL------FMVPDDPLGRNGPTLDEFLKKPVRA-QGSS-KAQHPSRAFTEHG
----------------------------------HQ------------------------
--------------QQ--GREEEEKGGGG--IRKTRETERLRRQLLEVFWGQDHKV---D
FIL---------------QREPYC-RDINQLSEALLSLNF--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
--------------------------------------------------------MSTW
-GLASP--TPDRFAVSAEA-EDKVREQQARLERIFSVGMSVLS---------KDCPENPH
IWLQLEGPKENVCRAKEYLKGLCSPELQSEIHYPPRLHCIFLGAQGFF-LDCLAWSTSAH
----------L---VPLVPGSLMISGLTEAFVMAQSRVEELVQRLSWDLQLQSFPGGPDS
GGVLRDFSALLQTREDAHTEALLRLPLAVQEELLSLVQEASRGQGP--------SRE-VG
S----P-------GLLSPQF--Q----GVRAP-LNEG----RDSVG------TGVAGSGK
SR------------------------------------------AVR--GQS--------
----------------------------------H----TVEKEGRKQDAVRDM----GS
GRKELSGE-------------------------------------EVWETG------VTY
R-----------SQLASG----------------------------------GA-EE---
-----VAPLRGKALGKQELP----------------QQRGG-FNVQGE---PSGAHVPCQ
RAA-----------------------------------------PTRGASLLQRLHN--G
SASPPRV-----------------------------------------------------
-------------PSPPPA-----------------------------------------
--------------PEPPWPCGDRDRDRDRD-RGDR------------------------
------------------------------------------------------------
------GDK----------QQA---------------GARGRG----S--P---------
--------------------------WKRG------TRG-----G-NLVTGTQRFQEALQ
DPFALCLANVPGQPDLRHIVIDGSNVAMVHGLQHYFSSRGIALAVQYFWDRGHRDI----
TVFVPQWRFSKDSKVRESHFLQKLYSLSLLSLTPSRVMDGKRISSYD-------DRFM-V
KLAEETDGIIVSNDQFRDLAEESDKWMAIIRER---------------------------
LLPFTFVGNL------FMVPDDPLGRNGPTLDEFLKKPVRK-QGSS-KSQQPSKGSTEQA
----------------------------------HEQ-----------------------
--------------QGKEV---E-RSNGG--IRKTRETERLRRQLLEVFWGQDHKV---D
FIL---------------QREPYC-RDINQLSEALLSLNF--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
--------------------------------------------------------MLL-
--SGGDPPAQEWFMVQTKS-KPRVQRQRLQVQRIFRVKLNAFQ----------SRPDTPY
FWLQLEGPRENMGKAKEYLKGLCNPELWKEVRYPPILHCAFLGAQGLF-LDCLCWSTLAY
----------L---VPGPPGSLMVGGLTESFIMTQNWLEELVGRLRWGPAPLLTPRGIWE
AEVTRAFGALVWIRGDQHAGDLLQLPPAVQELLLSLVRDAAGKEDI-IEWLSRFGISDSH
---SDP-------EVLI-------------------------------------------
-CPSQQQKEAPAMVSVGESPG---PFVDMGTLQ-----NRVPEN--SKRLSSLGATGSLI
---------PAQSTPQ----------ETANQLVRVGSNSQ---GG-MDSAQEEGP---VQ
ATSSQDSTNHTQA--------LLKQKQVQRIEDK--LLFQP--PVSALGVCPSWKAWTPG
PA--------FGPLWPGA------IAATFWRIN---ELHS----LHLAWLLSQACFNFPF
WQ-RPLGPIQLKLPGQNPLPLNLEWKQKELAPLPSAESPAGRPDGGLG---GEAALQNCP
RPEIPP-KVTSLLVVPGSSDVKDKVSSDLPQIGPPLTSTPQLQAGGESGDQGS-MQLDCK
GLEEGPAPVLPAG------------QGKPMAQGGLTDQSVPGAQTVPETLKVPMAAAVPK
AENPPRTQVPPAAPKVPTSQMMPA-AHTEPAAPKVPS-----------------------
-------------APTKP------AAQMMAT-AQKTVVNQPVL----AAQVEPTTPKTPQ
AQKMPV---AKTSPAGPKTPKAQAGAAATVSKASAASKA------------PAAPKVPVT
PKVSRAPKT--------PAAQKVPMDAGPTLDVAKLLSEVQPTSRASASLPKGQGQA-GR
QGPQPSGTLALSSKHQFQMEGLLGA-WEGAPRQPPRHLQ-----ANNTVTSFQRYHEALN
TPFELNLSGEPGNQGLRRVVIDGSSVAMVHGLQHFFSCRGIAMAVQFFWNRGHREV----
TVFVPTWQLKKNRRVRESHFLTKLHSLKMLSITPSQLENGKKITTYD-------YRFM-V
KLAEETDGIIVTNEQIHILMNNS-KKLM--VKDRL-------------------------
-LPFTFAGNL------FMVPDDPLGRDGPTLDEFLKKPNRLDTDIGNFLKV----WKTLP
PSSASVTELSED-ADSGPLESPPNMEEVREEKEERQDE---E-----------Q------
--RQGRGM--------QKAA-EEDDLDSSLASVFRVECPSLSEEILRCLSLHDPPDGALD
IDLLPGAASPYLGIPWD--GQAPCQQVLAHLAQLTIPSNFTALSFFVGFMDSHRDAIPDY
EALVGPLHSLLKQKPDWQWDQEHEEAFLALKRALVSALCLTAPNSQLPFRLEVTVSHVAL
TAILHQEHSGRKHPIAYTSKPLLPDEESQGPQSGGDSPYAVAWALKHFSRCIGDTPVVLD
LSYASRTMVDPEVREGRRFSKAWLIRWSLLVQDKGKRALELALLQGLLGENRLLTPA-AS
MPRFFQVLPPFSDLSTFVCIHMSGYCFYREDEWCAGFGLYVLSPTSPPVSLSFSCSPYTP
TYAHLAAVACGLERFGQSPLPVVFLTHCNWIFSLLWELLPLWRARGF-LSSDGAPLPHPS
LLSYIISLTSGLSSLPFIYRTSYRGSLFAVTVDTLAKQGAQGGGQWWSLPKDVPAP-TVT
PRAMGKRPNLLALQLSDSTLADIIARLQAGQKLSGSSPFSSAFNSLSLDKESGLLMFKGD
KKPRVWVVPTQLRRDLIFSVHDIPLGAHQRPEETYKKLRLLGWWPGMQEHVRDYCRSCLF
CIPRNLIGSELKVIESPW---P--LRS--TAPWSNLQIEVVGPVTISEEGHKHVLIVADP
NTRWVEAFPLKPYTHTAVAQVLLQHVFARWGVPVRLEAAQGPQFARHVLVSCGLALGAQV
ASLSRDLQFPCLTSSGAYWEFKRALKEFIFLHGKKWAASLPLLHLAFRASSTDATPFKVL
TGGESRLTEPLWWEMSSANIEGLKMDVFLLQLIGELLELHWRVADKASEK---AENRRFK
RESQEKEWNVGDQVLLLSLPRNGSSAKWVGPFYIGDRLSLSLYRIWGFPTPEKLGCIYPS
SLMKAFAKSGTPLSFKVLEQ----

------------------------------------------------------------
---------------------------------------------------------MEA
-AGGSPPGGPDVFAVPAEM-EESLREQQRNVERIFRVQLSILD---------APHPRSRH
IWLQLRGSKENVGRAKEFVKGLCGPELWEEIYYPPALHCVFLGAHGLF-LDCLCWATSAH
----------L---VPKGPGTLLLCGLAEAFALAQSRVEELERRLEGGGA------LVGD
AQVAGAFGALLESYGGEHVRELLALPGAVQQELLSLVRDLAPP----G----AAGWS---
----------------------G----SDRDE-EEEA----RAG---------SPEPWDQ
RR------------------------------------------E-----GR--------
----------------------------------H----EAEKGSRKKRGRKR-------
--EGSPGE-------------------------------------EDRRGQGRPGRERRS
R-----------SRAEVD-RR-A--------------------------REGPR-RPE--
-----SGPEPGFPLGVP-----------------------------------RAAAESCG
HPA-----------------------------------------WALAAD-LQAEAP--F
TSSLPRL-----------------------------------------------------
-------------NAEGPD-----------------------------------------
--------------PQPRPPGS--GS------RSPA------------------------
------------------------------------------------------------
------PRK----------RPP---------------GSRGRG----S--P---------
-------------------------RRPGGA--VGDGDG-----GGGVVTGSQRFQEALR
APFSLNLANVPGPPGLRHVIIDGSNVAMVRGWGGRTRGRGLLRPG------GQQSVVPSG
SGPSPRPRVTRTPKVKEGHFLTILQDLRLLSFTPSRVVDGKRITPYD-------DRFM-L
KLAEETDGVIVTNDQLQDLAKESGEWFEIISER---------------------------
LLPFTFVGNI------FMVPDDPLGRKGPTLDEFLRKPTSRGDGPS-VFEDPSRGAWSR-
------------------------------------------------------------
------------------RQEPEEGGDGR--RREPRETERLRNQLLEIFSGQDQKV---D
FVL---------------EREPRT-RDLNQLSEALLGLRF--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
--------------------------------------------------------MLL-
--SGGKPPAQEWFMVQTKS-KPRVHRQRLQVQRIFRVKVTAFQ----------SRPDTPY
FWLQLEGPRENTGKAKEYLKGLCNPELWKEVRYPPVLHCAFLGAQGLF-LDCLCWSTLAY
----------L---VPGPPGSLMVGGLTESFTMTQNWLEELVARLRWGPAPMITPRGVWE
TEVTRAFGALVWIRCDQYARDLLQLPPAVQELLLSLVRDAAGKEDI-IEWLGHFGISGIY
---PKP-------PDFL-----I-------------------------------------
-CPALQKKEGSSLVTIGESPV---PLQEIGTLN------RASEN--SKKLTGLGAAGSVV
---------PAQSTP--------Q--DTAQQLVRDGSNKQ---GDDRNSAGEEGAT--AQ
DPSSQDSANHTQA--------LLQQKQGQKTENR--ISLQS--P--ALSVCPSWKAWAPG
PA--------FGPSWPGT------IAATFWKIN---ELQS----LHLVWLLSQACFNFPF
WQ-RPVGPIQLRLPGQNPLPLKLEWKQKELVPLPTAESPACRPDGDLG---REAALKHSL
RPETPT-KIISLSVVPGDCGIKEKVSPGLSQVGPSSTSIPQAGV--ELGDEGR-ALSDCK
GPEKLSSSALSTEQ------GGPRIQERPMAQAGMTGQSVPDTPTMSETLEVTTAAAVSK
VECTP-TEGLPATPKVPTTLKKPA-VYTEPTAPQVPS-----------------------
-------------APTEPAAPA-----------------------------TPTTPQTPT
AQKTPS----VKTPAGPQ-----------------------------TPKVQTGIIAKAE
STAPKAPA--------------ASAIAGPTMDVTKLLSEEVQASKCRATVLKGQGKP-GR
QGLQSSSTMASRSKHQFLKEGLLGA-WDGTQRLSPH-SQ-----GTNIVTSFQRFNEALN
TPFEMNLSEEPGNPGLRRVVIDGSSVAMVHGLQHFFSCRGIAMAVQYFWNRGHREI----
TVFVPTWQLKKNRRVRESHFLTKLHRLKMLSITPSQLENGKKITTYD-------YRFM-V
KLAEETDGVIVTNEQIHILMNNS-KKLMV-KDR---------------------------
WLPFTFAGSL------FM-PDDPLGRDGPTLEEFLKKPNRLDMDIGNFLKV----WKTLP
PSSASISELGDA-ADAEPLEGPQNIEE-GEKGEESLEEELVE------------------
-------------EPGIPKPDEQEEQDSDPVSVFGVECPSFSEEILQCLSLHDPSEGALD
IDLLPVVSSPYLDVPWD--GKAPSQQVLTQLAQLTIPSNFTALSFFMGFMDSHRDVIPDY
EVLVGPLHSLLKQKPDWQWNQEHEKSFLALKRALVCALCLSTPNPDLPFYLEVTVSQVSL
TASLHQEHSGRKHPIAYTSKPLLPDEDSEGPQSGGDSPYAVAWALKHFSRCVGDNPVVLR
LSYASRTTVDNEAWDSRRASNAWLIRWSLLLQDKGKRELELSLLQGLLGENQLLTPA-SS
MPRVFQLLPPSSDLSTFICVHVSGYCFYHDDELCAGFGLYILSPTSPPVSLAFSCSPYTS
TYAHLAGVACGLERFGQSQLPVVFVTHCNWIFSVLWEFLPLWKVRGF-LSSDGASLPHPS
LLSYIISLTSCFSSLPFIYRTSYRGSLFAVTVDTLAKQGAQGGGQWWDLPKDVPVP-IVT
PHTKGRKPNLLALQMSDSTLANIIAKLQAGQKLSGPSPFSSAFNSLSLDQDSGLLMFKAE
KHPRVWVVPRQLRRDLIFSVHDSPMGDHQGPEDTYKTLRLLGWWPGMQDHVKDYCRSCLF
CIPRNLIGGELKVIESPWP-----LRS--TAPWSSLQIEVVGPVTVSEEGHKHVLIVADA
NTRWVEAFPLKPYTHVAVAQVLLQHVFARWGVPIRLEAAQGPQFARHVLVSCGLALGAQV
TTLSRSLQFPCLMSSEAYWEFKRALKEFIFLYGKKWAASLPLLHLAFRASTTEATPFQVL
TGGEMRLMEPSWWEMSRANIEGLKMDAFLLQLIRELLDLHWRVAEKASEK---AENRRFK
RESRESEWSVGDQVLLLSLPRNGSSAKWMGPFYIGDRLSLSLYRVWGFPVPDKLGCVYPS
SLMKAFPKNDTPLPLDLEQ-----

------------------------------------------------------------
--------------------------------------------------------MPTW
-GAGSP---PDRFAVCAEA-EAKVRERQPHVERIFSVRMSVLP---------KDCPENPH
IWLQLEGPKENASRAKEYLKGLCSPELQNEIHYPPKLHCIFLGAQGFF-LDCLAWSTSAH
----------L---VPGAPGSLLVSGLTEAFVMAQSRVEELVERLSWDFRPGPAPG----
AGVLRDFSALLPAQGDAHREALLQLPLAVQEELLSLVREAARGQGPQP----LPSWN-VG
S----P-------GPLGAQH--Q----GVRAL-LSEG----RESLD------TGPMGLQG
SR------------------------------------------GE-----R--------
----------------------------------H----VVEMEGGKQAGLREM----DL
GWKELPGE-------------------------------------EAWERE------VAF
R-----------SQSWG----------------------------------GEA-GQA--
-----GPL-KGKALGKEEAP----------------QERGR-FCVQGE---PPGAQGPYQ
RVA-----------------------------------------PLRGASLLQRLHN--G
KASPPRV-----------------------------------------------------
-------------PSPPPA-----------------------------------------
--------------PEPPWHCGDRGDRG------DR------------------------
------------------------------------------------------------
------GDK----------QPV---------------VARGRG----S--P---------
--------------------------WKRG------TRG-----G-NLVTGTQRFQEALQ
DPFTLCLANVPGQPDLRHIVIDGSNVAMVHGLQHHFSSRGIAIAVQYFWDRGHRDI----
TVFVPQWRFSKDSKVREGHYLQKLYSLSLLSLTPSRVMDGKRISSYD-------DRFM-V
KLAEETDGIIVSNDQFRDLAEESEKWMAIIRER---------------------------
LLPFTFVGNL------FMVPDDPLGRHGPMLDEFLKKPARA-QGSS-KAQHPSRGFAEHG
----------------------------------NQ------------------------
--------------QQ--GRKEEEKGSSG--IRKTRETERLRRQLLEVFRGQDHKV---D
FIL---------------QREPHC-RDINQLSEALLSLNF--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
--------------------------------------------------------MLL-
--SGGDPPAQEWFMVQTKS-KSRVQRQRLQVQRIFRVKLNAFQ----------SRPDTPY
FWLQLEGPRENMGKAKEYLKGLCNPELWKEVRYPPILHCAFLGAQGLF-LDCLCWSTLAY
----------L---VPGPPGSLMVGGLTESFIMTQNWLEELVGRLRWGPAPLLTPRGIWE
AEVTRAFGALVWIRGDQHAGDLLQLPPAVQELLLSLVRDAAGKEDI-IEWLSRFGISDSH
---SDP-------EVLI-------------------------------------------
-CPPQQQKEAPALVSVGESPG---PFVDMGTLQ-----NRVPEN--SKRLSSLGATGSLI
---------PAQSTPQ----------ETANQLVRVGSNSQ---GG-MDSAQEEGP---VQ
ATSSQDSTNHTQA--------LLKQKQVQRIEDK--LLFQP--PVSALGVCPSWKAWTPG
PA--------FGPLWPGA------IAATFWRIN---ELHS----LHLAWLLSQACFNFPF
WQ-RPLGPIQLKLPGQNPLPLNLEWKQKELAPLPSAESPAGRPDGGLG---GEAALQNCP
RPEIPP-KVTSLLVVPGSSDVKDKVSSDLPQIGPPLTSTPQLQAGGESGDQGS-IQLDCK
GLEEGPAPVLPTW------------QGKPMAQGGLTDQSVPGAQTVPETLKVPMAAAVPK
AENPPRTQVPPAAPKVPTSQMMPA-VHTEPAAPKVPS-----------------------
-------------APTKP------AAQMMAT-AQKTVVNQPVL----AAQVEPTTPKNPQ
AQKMPV---AKTSPAGPKTPKAQAGPAATVSKASAASKA------------PAAPKVPVT
PKVSRAPKT--------PAAQKVPMDAGPTLDVAKLLSEVQPTSRASASLPKGQGQA-GR
QGPQPSGTLALSSKHQFQMEGLLGA-WEGAPRQPPRHLQ-----ANNTVTSFQRYHEALN
TPFELNLSGEPGNQGLRRVVIDGSSVAMVHGLQHFFSCRGIAMAVQFFWNRGHREV----
TVFVPTWQLKKNRRVRESHFLTKLHSLKMLSITPSQLENGKKITTYD-------YRFM-V
KLAEETDGIIVTNEQIHILMNNS-KKLM--VKDRL-------------------------
-LPFTFAGNL------FMVPDDPLGRDGPTLDEFLKKPNRLDTDIGNFLKV----WKTLP
PSSASVTELSDD-ADSGPLESPPNMEEVREEKEERQDE---E-----------Q------
--RQGQGT--------QKAA-EEDDLDSSLASVFRVECPSLSEEILRCLSLHDPPDGALD
IDLLPGAASPYLGIPWD--GKAPCQQVLAHLAQLTIPSNFTALSFFMGFMDSHRDAIPDY
EALVGPLHSLLKQKPDWQWDQEHEEAFLALKRALVSALCLTAPNSQLPFRLEVTVSHVAL
TAILHQEHSGRKHPIAYTSKPLLPDEESQGPQSGGDSPYAVAWALKHFSRCIGDSPVVLD
LSYASRTTVDPEAREGRRLPKAWLIRWSLLVQDKGKRALELALLQGLLGENRLLTPA-AS
MPRFFQVLPPFSDLSTFVCIHMSGYCFYREDEWCAGFGLYVLSPTSPPVSLSFSCSPYTP
TYAHLAAVACGLERFGQSPLPVVFLTHCNWIFSLLWELLPLWRARGF-LSSDGAPLPHPS
LLSYIISLTSGLSSLPFIYRTSYRGSLFAVTVDTLAKQGAQGGGQWWSLPKDVPAP-TVT
PHAMGKRPNLLALQLSDSTLADIIARLQAGQKLSGSSPFSSAFNSLSLDKESGLLMFKGD
KKPRVWVVPTQLRRDLIFSVHDIPLGAHQRPEETYKKLRLLGWWPGMQEHVRDYCRSCLF
CIPRNLIGSELKVIESPW---P--LRS--TAPWSNLQIEVVGPVTISEEGHKHVLIVADP
NTRWVEAFPLKPYTHTAVAQVLLQHVFARWGVPVRLEAAQGPQFARHVLVSCGLALGAQV
ASLSRDLQFPCLTSSGAYWEFKRALKEFIFLHGKKWAASLPLLHLAFRASSTDATPFKVL
TGGESRLTEPLWWEMSSANIEGLKMDVFLLQLVRELLELHWRVADKASEK---VENRRFK
RESQEKEWNVGDQVLLLSLPRNGSSAKWVGPFYIGDRLSLSLYRIWGFPTPEKLGCIYPS
SLMKAFAKSGTPLSFKVLEQ----

------------------------------------------------------------
--------------------------------------------------------MPTW
-EARPA--SPDRFAVSAEA-ENKVREQQPHVERIFSVGVSVLP---------KDCPDNPH
IWLQLEGPKENASRAKEYLKGLCSPELQDEIHYPPKLHCIFLGAQGFF-LDCLAWSTSAH
----------L---VPRAPGTLMISGLTEAFVMAQSRVEELTERLSWDFTPGPSSGASQC
TGVLRDFSALLQSPGDAHREALLQLPLAVQEELLSLVQEASSGQGPGA----LASWE-RR
S----S-------GLLRAQC--Q----EERAP-PSDG----RESLD------TGSVGPRD
SR------------------------------------------GAR--GDN--------
----------------------------------Y----AVEKEGGKQGGPREM----DL
GWKELPGE-------------------------------------EAWERE------VAL
R-----------PQSVGG----------------------------------GL-RES--
-----APL-KGKALGKEEVT----------------QGGGG-VCVHRE---PPGAHGSCH
RAA-----------------------------------------QSRGASLLQRLHN--G
NASPPRV-----------------------------------------------------
-------------PSPPPA-----------------------------------------
--------------PEPPWHCGDRGDWGDRGDGGDR------------------------
------------------------------------------------------------
------GDK----------QQG---------------MARGRG----P--Q---------
--------------------------WKRG------ARG-----G-NLVTGTQRFKEALQ
DPFTLCLANVPGQPDLRHIVIDGSNVAMVHGLQHYFSSRGIAIAVQYFWDRGHRDI----
TVFVPQWRFSKDSKVRESHFLQKLYSLSLLSLTPSRVMDGKRISSYD-------DRFM-V
KLAEETDGIIVSNDQFRDLAEESEKWMAIIRER---------------------------
LLPFTFVGNL------FMVPDDPLGRNGPTLDEFLKKPART-QGSS-KAQHPSRGFAEHG
----------------------------------KQQ-----------------------
---------------H--G-REEEKGSGG--IRKTRETERLRRQLLEVFWGQDHKV---D
FIL---------------QREPYC-RDINQLSEALLSLNF--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
--------------------------------------------------------MLL-
--SGGDPPAQEWFMVQTKS-KPRVQRQRLQVQRIFRVKLNAFQ----------SRPDTPY
FWLQLEGPRENMGKAKEYLKGLCSPELWKEVRYPPILHCAFLGAQGLF-LDCLCWSTLAY
----------L---VPGPPGSLMVGGLTESFIMTQNWLEELVGRLRWGPAPLLTPRGIWE
AEVTRAFGALVWIRGDQHAGDLLQLPPAVQELLLSLVRDAAGKEDI-IEWLSRFGISDSH
---SDP-------EVLI-------------------------------------------
-CPPQQQKEAPAMVSVGESPG---PFVDMGTLQ-----NRGPEN--SKRLSSLGATGSLI
---------TAQSTPQ----------EAANQLVRVGSNNQ---DG-MDSAQEEGT---VQ
ATSSQDSTNHTQA--------LLKQRQVQKIEDK--LLFQP--PVSALGVCPPWKAWTPG
PA--------FGPLWPGA------IAATFWRIN---ELHS----LHLAWLLSQACFNFPF
WQ-RPLGPIQLKLPGQNPLPLNLEWKQKELAPLPSAESPAGRPDGGLG---GEAALQNCP
RPEISP-KVTSLLVVPGSSDVKDKVSSDLPQIGPPLTSTPQLQAGGEPGDQGS-MQLDFK
GLEEGPAPVLPTG------------QGKPVAQGGLTDQSVPGAQTVPETLKVPMAAAVPK
AENPSRTQVPSAAPKLPTSRMMLA-VHTEPAAPEVPL-----------------------
-------------APTKP------TAQLMAT-AQKTVVNQPVL----VAQVEPTTPKTPQ
AQKMPV---AKTSPAGPKTPKAQAGPAATVSKAPAASKA------------PAAPKVPVT
PRVSRAPKT--------PAAQKVPTDAGPTLDVARLLSEVQPTSRASVSLLKGQGQA-GR
QGPQSSGTLALSSKHQFQMEGLLGA-WEGAPRQPPRHLQ-----ANSTVTSFQRYHEALN
TPFELNLSGEPGNQGLRRVVIDGSSVAMVHGLQHFFSCRGIAMAVQFFWNRGHREV----
TVFVPTWQLKKNRRVRESHFLTKLHSLKMLSITPSQLENGKKITTYD-------YRFM-V
KLAEETDGIIVTNEQIHILMNSS-KKLM--VKDRL-------------------------
-LPFTFAGNL------FMVPDDPLGRDGPTLDEFLKKPNRLDTDIGNFLKV----WKTLP
PSSASVTELSDD-ADSGPLESLPNMEEVREEKEERQDE---E-----------Q------
--RQGQGT--------QKAA-EEDDLDSSLASVFRVECPSLSEEILRCLSLHDPPDGALD
IDLLPGAASPYLGIPWD--GKAPCQQVLAHLAQLTIPSNFTALSFFMGFMDSHRDAIPDY
EALVGPLHSLLKQKPDWQWDQEHEEAFLALKRALVSALCLMAPNSQLPFRLEVTVSHVAL
TAILHQEHSGRKHPIAYTSKPLLPDEESQGPQSGGDSPYAVAWALKHFSRCIGDTPVVLD
LSYASRTTADPEVREGRRVSKAWLIRWSLLVQDKGKRALELALLQGLLGENRLLTPA-AS
MPRFFQVLPPFSDLSTFVCIHMSGYCFYREDEWCAGFGLYVLSPTSPPVSLSFSCSPYTP
TYAHLAAVACGLERFGQSPLPVVFLTHCNWIFSLLWELLPLWRARGF-LSSDGAPLPHPS
LLSYIISLTSGLSSLPFIYRTSYRGSLFAVTVDTLAKQGAQGGGQWWSLPKDVPAP-TVS
PHAMGKRPNLLALQLSDSTLADIIARLQAGQKLSGSSPFSSAFNSLSLDKESGLLMFKGD
KKPRVWVVPTQLRRDLIFSVHDIPLGAHQRPEETYKKLRLLGWWPGMQEHVKDYCRSCLF
CIPRNLIGSELKVIESPW---P--LRS--TAPWSNLQIEVVGPVTISEEGHKHVLIVADP
NTRWVEAFPLKPYTHTAVAQVLLQHVFARWGVPVRLEAAQGPQFARHVLVSCGLALGAQV
ASLSRDLQFPCLTSSGAYWEFKRALKEFIFLHGKKWAASLPLLHLAFRASSTDATPFKVL
TGGESRLTEPLWWEMSSANIEGLKMDVFLLQLVGELLELHWRVADKASEK---AENRRFK
RESQEKEWNVGDQVLLLSLPRNGSSAKWVGPFYIGDRLSLSLYRIWGFPTPEKLGCIYPS
SLMKAFAKSGTPLSFKVLEQ----

------------------------------------------------------------
--------------------------------------------------------MLL-
--SGGDPPAQEWFMVQTKS-KPRVQRQRLQVQRIFRVKLNAFQ----------SRPDNPY
FWLQLEGPRENMGKAKEYLKGLCSPELWKEVRYPPILHCAFLGAQGLF-LDCLCWSTLAY
----------L---VPGPPGSLMVGGLTESFIMTQNWLEELVGRLRWGPAPLLTPRGIWE
AEVTRAFGALVWIRGDQHAGDLLQLPPAVQELLLSLVRDAAGKEDI-IEWLSRFGISDSH
---SDP-------EVLI-------------------------------------------
-CPPQQQKEAPAMVSVGESPG---PFVDMGTFQ-----NRGPEN--SKRLSSLGATGSLI
---------PAQSTLQ----------EAANQLVRVGSNNQ---DG-MDSAQEEGP---VQ
ATSSQDSTNHTQA--------LLKQRQVQRIEDK--LLFQP--PVSALGVCPSWKAWTPG
PA--------FGSLWPGA------IAATFWRIN---ELHS----LHLAWLLSQACFNFPF
WQ-RPLGPIQLKLPGQNPLPLNLEWKQKELAPLPSAESPAGRPDGGLG---GEAALQNCP
RPEIPP-KVTSLLVVPGSSDIKDKVSSDLPQIGPRLTATPQIQAGGEPGDQGS-MQLDCK
GLEEGPAPVLPTG------------QGKPVAQGGLTDQSVPGAQTVPETLKVPVAAAVPK
AENPPRTQVPPAAPKVPTSRMMLA-VHTEPAAPEVPL-----------------------
-------------TPTKP------TAQSMAT-AQKTVVNQPVL----AAQVEPTTPKTPQ
AQKTPV---AKTSPAGPKTPKAQAGPAATVSKAPAASKA------------PAAPKVPVT
PKVPRAPKT--------PAAQKVSTDAGQTLDVAKLLSEVQPTSRASVSLPKGQGQA-GR
QGPQPSGTLAFSSKHQFQMEGLLGA-WEGAPRQPPRHLQ-----ANSTVTSFQRYHEALN
TPFELNLSGEPGNQGLRRVVIDGSSVAMVHGLQHFFSCRGIAMAVQFFWNRGHREV----
TVFVPTWQLKKNRRVRESHFLTKLHSLKMLSITPSQLENGKKITTYD-------YRFM-V
KLAEETDGIIVTNEQIHILMNNS-KKLM--VKDRL-------------------------
-LPFTFAGNL------FMVPDDPLGRDGPTLDEFLKKPNRLDTDIGNFLKV----WKTLP
PSSASITELSDD-ADSGSLESLPNMEEVREEKEERQDE---E-----------Q------
--RQGQGT--------QKAA-EEDDLDSSLASVFRVECPSLSEEILRCLSLHDPPDGALD
IDLLPGAASPYLGIPWD--GKAPCQQVLAHLAQLTIPSNFTALSFFVGFMDSHRDAIPEY
EALVGPLHSLLKQKPDWQWDQEHEEAFLALKRALVSALCLMAPNSQLPFRLEVTVSHVAL
TAILHQEHSGRKHPIAYTSKPLLPDEESQGPQSGGDSPYAVAWALKHFSRCIGDTPVVLD
LSYASRTTADPEVREGRRVSKAWLIRWSLLVQDKGKRALELALLQGLLGENRLLTPA-AS
MPRFFQVLPPFSDLSTFVCIHMSGYCFYREDEWCAGFGLYVLSPTSPPVSLSFSCSPYTP
TYAHLAAVACSLERFGQSPLPVVFLTHCNWIFSLLWELLPLWRARGASLSSDGGILPHPS
LLSYIISLTSGLSSLPFIYRTSYRGSLFAVTVDTLAKQGAQGGGQWWSLPKDVPAP-TVS
PHAMGKRPNLLALQLSDSTLADIIARLQAGQKLSGSSPFSSAFNSLSLDKESGLLMFKGD
KKPRVWVVPTQLRRDLIFSVHDIPLGAHQRPEETYKKLRLLGWWPGMQEHVKDYCRSCLF
CIPRNLIGSELKVIESPW---P--LRS--TAPWSNLQIEVVGPVTISEEGHKHVLIVADP
NTRWVEAFPLKPYTHTAVAQVLLQHVFARWGVPVRLEAAQGPQFARHVLVSCGLALGAQV
ASLSRDLQFPCLTSSGAYWEFKRALKEFIFLHGKKWAASLPLLHLAFRASSTDATPFKVL
TGGESRLMEPLWWEMSSANIEGLKMDVFLLQLVGELLELHWRVADKASEK---AENRRFK
RESQEKEWNVGDQVLLLSLPRNGSSAKWVGPFYIGDRLSLSLYRIWGFPTPEKLGCIYPS
SLMKAFAKSGTPLSFKVLEQ----

------------------------------------------------------------
--------------------------------------------------------MPTW
-GAGSL--TPDRFTVSAEA-EDKVRAEQARLERIFRVGVCILP---------RDCRENPH
IWLQLEGPKENVGRAKEYLKGLCSPELQNEIHYPPRLHCIFVGARGFF-LDCLAWSTSAH
----------L---VPGAPGSLMISGLTEAFVMAQSRVEELVDRLSWDLRPGLYPTTAQC
SGVLGAFPALLQPREDAYTEALLQLPSAVQEELLSLVQEA---------------WP-LE
Q----R-------SPLGALH--Q----EVRAP-LSEG----RESLD------AGYVGQGE
AR------------------------------------------GAS--GVS--------
----------------------------------H----TVEKNRGQQGSSREV----DL
GWKE------------------------------------------AWEKE------VTS
Q-----------TEPAGD----------------------------------EI-VE---
-----MGCLKGIALAREEVI----------------QGGGG-FSVHNE---PPGTQVPCQ
RTA-----------------------------------------HSRGASLLQRLHN--G
EATPPRV-----------------------------------------------------
-------------PSPPPA-----------------------------------------
--------------PEPPWPCGDQGD------LGDR------------------------
------------------------------------------------------------
------GDK----------QQ-----------------GRGRG----S--S---------
--------------------------WKRG------TRG-----G-NLVTGTQRFQEALQ
DPFTLCLANVPGQPDLRHIVIDGSNVAMVHGLQHYFSSRGIAIAVQYFWDRGHRDI----
TVFVPQWRFSKDGKVREIHFLQKLYSLSLLSLTPSRVMDGKRISSYD-------DRFM-L
KLAEERNGIIVSNDQFRDLAEESDKWMAIIRER---------------------------
LLPFTFVGNL------FMVPDDPLGRNGPTLDEFLKKPARK-QVST-KAQHPSKGFAGHG
----------------------------------NQQ-----------------------
--------------QGKE----EEKVSSA--IRKTRETERLRRQLLEVFRGQDHKV---D
FIL---------------QREPYC-RDINQLSEALLSLNF--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
--------------------------------------------------------MPTW
-EAGCP--SPDRFAVSAEA-EDKVRQQQLHVERIFRVGMSILP---------KDCLQNPH
IWLQLEGPKENASRAKEYLKGLCSPELQDEIHYPPKLHCIFLGAQGFF-LDCLTWSTSAH
----------L---VPGAPGSLMISGLAEAFVMAQSRVEGLVERLSWDLQPGPSLGASQC
AGVLGDFSALLQPWGDAHREALLQLPLAVQEELLSLVQEVSRCQGPQT----LSSWE-ER
S----S-------GLLGAQY--Q----EVRTS-PSEG----REPLD------TGSMVWGE
SR------------------------------------------GVR--GES--------
----------------------------------Y----AVGKEEGKQSGPREM----DL
GWKELPGE-------------------------------------EAWERE------VAF
R-----------PQLVPK----------------------------------GA-KEV--
-----GPL-KGKALGKEGVS----------------QERGG-VCVQGE---PPGAHGPCQ
RAA-----------------------------------------QLRGASLLQRLHN--G
QASPLRV-----------------------------------------------------
-------------PSPPPA-----------------------------------------
--------------PEPPWHCGDRGD----------------------------------
------------------------------------------------------------
--------K----------QQS---------------MARGRG----S--P---------
--------------------------WKRG------PRG-----G-NLVTGTQRFQEALQ
DPFTLCLANVPGQPDLRHIVIDGSNVAMVHGLQHYFSSRGIAIAVQYFWDRGHRDI----
TVFVPQWRFSKDARVRESHFLQKLYSLSLLSLTPSRVMDGKRISSYD-------DRFM-V
KLAEETDGIIVSNDQFRDLAEESEKWMAIIRER---------------------------
LLPFTFVGNL------FMVPDDPLGRNGPTLDEFLKKPART-QESS-KAHSPSRGFTEHG
----------------------------------NQQ-----------------------
---------------Q--G-REEEKGSGG--IRKNRETERLRRQLLEVFWGQDHKV---D
FIL---------------QREPYC-RDINQLSEALLSLNF--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------MDSAHEAGP---VQ
ASSSQDPVDHTQA--------LSQQRQVRRGEDK--LPLQP--PVSALGVCSPWKAWTPG
PA--------FGPLWPGA------IAATFWRIN---ELHS----LHLAWLLSQACFSFPF
WQ-RPLGPIQFKLPGQNPLPLNLEWKQKELVPLPSVEGPDCRPDGGPG---GETALQNCP
RPETPN-NVMSLLVVSGGSGVKDKANPALPQIGPPLTSAPQLQARSEPGDQGS-MQWDNK
RPEEGPFPVMPTGQGVP------TAQGRPKAQGGLAAPVGPDPKTVPETCKVPMAAAMPT
AQTPPANPALPAPPKVPATQMMPA-VHEEPAAPKVPL-----------------------
-------------APMKP------AAQVLPT-AQKAVVGRLAP----AAQMVPAAPKTPT
VQKRPA---AKTSPAGPQTPRAQTGPVAKPGST--------APKTPTAPKAPAAPKAPAA
PKTSRAPKT--------PTAQKAPTDPGPTLDVAKLLSEGQPSSKGRASFLKSQGEP-GR
QGPPSSGTLAPSSKGQPQVEGFLGA-WEGAPRQPPRHPQ-----ANSTVTSFQRYHEALN
TPFELNLSGEPGNQGLRRVVIDGSSVAMVHGLQHFFSCRGIAMAVQYFWNRGHREV----
TVFVPTWQLKKNRRVRESHFLTKLHSLKMLSITPSQLENGKKITTYD-------YRFM-V
KLAEETDGVIVTNEQLHVLMNNS-KKLMV-KDR---------------------------
LLPFTFAGNL------FMVPDDPLGRDGPTLDEFLKKPNRLDTDIGNFLKV----WKTLP
PSSASLSEPVDE-ADPWPPESLQSVKEVREEKEERQDEEQREEQETQKL---AE------
--E---------EEEEEEEKEEDDDQDSLLVSVFRAECPSLSEEILRCLSLHDPMDEALD
IDLLPVVASPSLDIPWD--GKAPCQQVLAHLAQLTIPSNFTALSFFVGFMDSHRDVIPDY
EALVGPLHSLLKQKPDWQWALEHEKAFLALKRALVSALCLSAPNSQLPFRLEVTVSQVAL
MAVVYQEHSGRKHPVAYTSKPLLPDEESAGPQSGGDSPYAVAWALKYFSRCIGDTPVVLG
LSYASRTTADPEAWDGRRLAKAWLIRWSLLVQDKGKRALELALLQGLLGENRLLTPA-AS
MPRFFQVLPPFSDLSTFVCIHMSGYCFYREDEWCAGFGLYVLSPTSPPVSLSFSCSPYTP
TYAHLAAVACGLERFGRSHLPVVFLTHCNWIFSLLWELLPLWRARGF-LSSDGAPLPHPG
LLSYIIALVSGLSSLPFIYRTSYRGSLFAVTVDTLAKQGAQGSGQWWHLPNDVPVP-VVT
RRTAGKKPDLLALQRSDSTLADIIAKLQAGQKLPNSSPFSSAFNSLSLDRESGLLMFKGD
KKPRVWVVPRQLRRDLIFAVHDLPMGGHQRPEETFKKLRLLGWWPGMQEHVREYCRSCLY
CIPRNLTGSELKVIESLW---P--LRS--TAPWSNLQIEVVGPVTVSEEGHKHVLIVADP
NTRWVEAFPLKPYTHMAVAQVLLQHVFARWGVPVRLEAAQGPHFARHVLVSCGLALGAQV
ASPSRDLQFPCLTSSGAYWEFKRALKEFIFLHGKKWAASLPLLHLAFRASSGLATPFQIL
TGGEERLTEPLWWEMSSANIEGLKMDVFLLQLMGELLELHWRVAEKASEK---AENRRFK
RESQEKEWNVGDQVLLLSLPRNGSSAKWVGPFYIGDRLSLSLYRVWGFPTPEKLGCIYPS
SLMKTFAKSGTPLSFKVLEQ----

------------------------------------------------------------
--------------------------------------------------------MPTW
-GAGSP--TPDRFTVSAEA-EEKVRAQQSRLERIFSVGVSVLP---------KDCPENPH
IWLQLEGSKENVGRAKEYLKGLCSPELQNEIHYPPRLHCIFLGAQGFF-LDCLAWSTSAH
----------L---VPGAPGSLMISGLTEAFVMAQSRVEDLV-----DFRPGSYPMTSQS
AGVLRDFSALLQPWEDTHTEALLQLPLAVQEKLLSLVQEASRGHGPLT----PASWG-GR
S----P-------GLLGALH--Q----GVRPS-LSEG----GESLD------AGSVGQGE
SR------------------------------------------GAS--GVS--------
----------------------------------H----TVE-NRGKQGGLREV----DQ
GWKELLGE-------------------------------------EAWEKE------VTF
R-----------SQPAGG----------------------------------GT-GE---
-----MGFLKGMALGKEGVP----------------QQRGG-SGVQCE---PPGAQGHSQ
KAA-----------------------------------------QSRGASLLQRLHN--G
EASPLRV-----------------------------------------------------
-------------PSPPPA-----------------------------------------
--------------PEPPWPCGDRGD------LGDR------------------------
------------------------------------------------------------
------GDK----------QQ-----------------ARGRG----S--P---------
--------------------------WKRG------TRG-----G-NLVTGTQRFQEALQ
DPFTLCLANVPGQPDLRHIVIDGSNVAMVHGLQHYFSSRGIAIAVQYFWDRGHRDI----
TVFVPQWRFSKDGKVREIHFLQKLYSLSLLSLTPSRVMDGKRISSYD-------DRFM-L
KLAEETSGIIVSNDQFRDLAEESDQWMAIIRER---------------------------
LLPFTFVGNL------FMVPDDPLGRNGPTLDEFLKKPARK-QLSS-KAQHPSKGFAGYG
----------------------------------NQQ-----------------------
--------------QGRE----EEKGSGG--IRKTRETERLRRQLLEVFGGQDHKV---D
FIL---------------QREPYC-RDINQLSEALLSLNF--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
--------------------------------------------------------MPTW
-GAGSP--SPDRFAVSAEA-EDKVREQLPRVERIFRVGMSVLP---------KDCPENPH
IWLQLEGPKENASRAKEYLKGLCSPELQNEIHYPPKLHCIFLGAQGFF-LDCLTWSTSAH
----------L---VPGVPGSLMVSGLTEAFVMVQSRVEELVERLSWDFRLGPSPGASQC
AGVLREFSALLQARGDAHTEALLQLPQAVQEELLSLVQEASRGQGPQA----FPSWG-WG
G----P-------GPLGAQQ--Q----GVRTP-LGDG----GVSLD------TGPTGWQE
SR------------------------------------------GE-----R--------
----------------------------------H----AVEKEGTKQGGAREM----DL
GWKEWPGE-------------------------------------EAWERQ------VAF
R-----------PQSGGG-EA-S--------------------------GGGEA-GQA--
-----GPP-KGKALGKEGVP----------------QERGR-LGVQGQ---PPSTQGPYQ
RAS-----------------------------------------QLRGASLLQRLHN--G
EASPPRV-----------------------------------------------------
-------------PSPPPA-----------------------------------------
--------------PEPPWHCGDRGDRGD------R------------------------
------------------------------------------------------------
------ADK----------QLV---------------VARGRG----S--P---------
--------------------------WKRG------TRG-----G-NLVTGTQRFQEALQ
DPFTLCLANVPGKPDLRHIVIDGSNVAMVHGLQHYFSSRGIAIAVQYFWDRGHRDI----
TVFVPQWRFSKDSKVREGHFLHKLYSLSLLSLTPSRVLDGKRISSYD-------DRFM-V
KLAEETDGIIVSNDQFRDLAEESEKWMAIIRER---------------------------
LLPFTFVGNL------FMVPDDPLGRNGPTLDEFLKKPVRA-PGSS-KPQQSARGVTEHS
----------------------------------NQ------------------------
--------------QQ--GRKEEEKGNGG--IRKTRETERLRRQLLEVFWGQDHKV---D
FIL---------------QREPYC-RDINQLSEALLSLNF--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
--------------------------------------------------------MLL-
--SGGDPPAQEWFMVQTKS-KPRVQRQRLQVQRIFRVKLNAFQ----------SRPDTPY
FWLQLEGPRENMGKAKEYLKGLCSPELWKEVRYPPILHCAFLGAQGLF-LDCLCWSTLAY
----------L---VPGPPGSLMVGGLTESFIMTQNWLEELVGRLRWGPAPLLTPRGIWE
AEVTRAFGALVWIRGDQHAGDLLQLPPAVQELLLSLVRDAAGKEDI-IEWLSHFGISDSH
---SDP-------EVLI-------------------------------------------
-CPPQQQKEAPAMVSVGESPG---PFLDMGTLQ-----NRGPEN--SKRLSSLGATGSLI
---------PAQSTPQ----------ETANQLVRVVSNNQ---GG-MDSAREEGP---VQ
ATSSQDSTNYTQA--------LLQQRQVQRVEDK--LLFQP--PVSALGVCPPWKAWTPG
TA--------FGPLWPGA------IAATFWRIN---ELHS----LHLAWLLSQACFNFPF
WQ-RPLGPIQLKLPGQNPLPLNLEWKQKELAPLPSAESPAGRPDGGPG---GEAVLQNCP
RPETPP-KVMSLLVVPESSDVKDKVSSDLPQIGPPLTSTPQLQAGGEPGDQGS-MQSDCK
GLEEGPAAVLSAG------------KGKPMAQGGLTDHSVPGTQTVPEALKVPMAAAVPK
AENPPRTQVPSAAPKVPTSQMMLA-VHTEPAAPKVPL-----------------------
-------------APTKP------AAQLMAT-AQKTVVNQPVL----AAQVEPITPKTPQ
DQKMPV---AKTSPAGPKTPKAQTGPAATASKAPAAPKTTAAPKTPA------APKVPMT
PKVSKAPKT--------LVAQKVPTDAGPTLDVAKLLSEVQPTSRASASLPKGQGQA-GR
QGPQPSGTLAVSSKHQFQMEGLLGA-WEGAPRQPPRHLQ-----ANSTVTSFQRYHEALN
TPFELNLSGEPGNQGLRRVVIDGSSVAMVHGLQHFFSCRGIAMAVQFFWNRGHREV----
TVFVPTWQLKKNRRVRESHFLTKLHSLKMLSITPSQLENGKKITTYD-------YRFM-V
KLAEETDGIIVTNEQIHILMNNS-KKLMV-K-DR--------------------------
LLPFTFAGNL------FMVPDDPLGRDGPTLDEFLKKPNRLDTDIGNFLKV----WKTLP
PSSASVTELSDD-TDSGPLESLPNVEEVREEKEERQDE---E-----------Q------
--RQGQGT--------QKLA-EEDDLDSSLASVFRVECPSLSEEILRCLSLHDPPDGALD
IDLLPGAASPYLGIPWD--GKAPCQQVLAHLAQLTIPSNFTALSFFVGFMDSHRDAIPDY
EALVGPLHSLLKQKPDWQWHQDHEEAFLALKRALVSALCLTVPNSQLPFRLEVTVSHVAL
TAILHQEHSGRKHPIAYTSKPLLPDEESQGPQSGGDSPYAVAWALKHFSRCIGDTPVVLD
LSYASRTTADPEVRDSRRVSKAWLIRWSLLVQDKGKRALELSLLQGLLGENRLLTPA-AS
MPRFFQVLPPFSDLSTFVCIHMSGYCFYREDEWCAGFGLYVLSPTSPPVSLSFSCSPYTP
TYAHLAAVACGLERFGQSPLPVVFLTHCNWIFSLLWELLPLWRARGF-LSSDGAPLPHPS
LLSYIISLTSGLSSLPFIYRTSYRGSLFAVTVDTLAKQGAQGGGQWWSLPKDVPVP-VVT
PHAMGRRPNLLALQLSDSTLADIIARLQGGQKLSGSSPFSSAFNSLSLDKESGLLMFKGD
KKPKVWVVPTQLRRDLIFCVHDIPLGAHQRPEETYKKLRLLGWWPGMQEHVRDYCRSCLF
CIPRNLIGSELKVIESPW---P--LRS--TAPWSNLQIEVVGPVTISEEGHKHVLIVADP
NTRWVEAFPLKPYTHTAVAQVLLQHVFARWGVPVRLEAAQGPQFARHVLVSCGLALGAQV
ASLSRDLQFPCLTSSGAYWEFKRALKEFIFLHGKKWAASLPLLHLAFRASSTDATPFKVL
TGGEARLTEPLWWEMSSANIEGLKMDVFLLQLVGELLELHWRVADKASEK---AENRRFK
RESQEKEWNVGDQVLLLSLPRNGSSAKWVGPFYIGDRLSLSLYRIWGFPTPEKLGCIYPS
SLMKTFAKSGTPLSFKVLEQ----

------------------------------------------------------------
--------------------------------------------------------MLL-
--SGGDPPAQEWFMVQTKS-KPRVQRQRLQVQRIFRVKLNAFQ----------SRPDTPY
FWLQLEGPRENTGKAKEYLKGLCSPELWKEVRYPPILHCAFLGARGLF-LDCLCWSTLAY
----------L---VPGPPGSLMVGGLTESFIMTQNWLEELVARLRWGPASLLTPRGVWE
AEVTRAFGALVWIRGDQHAGDLLQLPPAVQELLLSLVRDAAGKEDI-IEWLGHFGISNPH
---SDP-------EVLI-------------------------------------------
-CPPQQQKEGSALVSVAESPG---SFLEMGALR-----NGGSEN--SKRLSSLGATRSLT
---------SAQSTQQ----------ETANQLVRVGSSKQ---SG-TDGAREEEP---AQ
ATSSPVSAISTPA--------LLQPRQAHRLDDK--LPLQP--PVSALSVCPPWRAWAPG
PA-----------LWPGA------IATTFWRIN---ELHS----LHLAWLLSQACFTFPF
WQGRPLGAIQLKLPGPAPLPLNLEWKQKELVPLPSAESPACRLDEGLG---TETVLQNCP
KPETPQ-KIMSVLLVPGASNVKDEVRLGLPQIGPPLPSAPCLPVGGQPGDQGNNTQSDCK
GLGEGSSPVPPAGQEV------------PTAQGGQTAQSVPEVQTVPETHQVPLVAAVPK
AENPPTPQELPATTQVPTAQGRPA-VPTEPATPKVPL-----------------------
-------------APAEPAA------QVMPT-TPHAA-GQPA--AAATAQVAAANPKTRA
AQKAPA---AKTPPAGSKTPKAPSGAGRKTES--------------TTPKAPTTPKAPAA
SKAPKAPKT--------PATQKAPTEAKPALDVAKLLREVQPSSRGSTASPKSQGEA-GR
QGRQPGGTLAASSKHPFQMEGLLGA-WEGTPRQLPRNQQ-----AKNTVTSFQRYHEALN
TPFELNLSGEPGNQSLRRVVIDGSSVAMVHGLQHFFSCRGIAMAVQYFWNRGHREV----
TVFIPTWQLKKNRRVRESHFLNKLHSLKMLSITPSQLENGKKITTYD-------YRFM-V
KLAEETDGIIVTNEQIHVLMNSS-KKLMV-KDR---------------------------
LLPFTFAGNL------FMVPDDPLGRDGPTLDEFLKKPNRLDADIGNFLKV----WKTLP
PSSASIHKSSGD-LDPEPAESAQKVGGVREKEKEKKEEKKEEEKKKEEKKEVEKKEEKKE
VEKKEVEEQVKKEGQGMQKPAEEDDLGSSLASVFGVECPSLSEEILRCLSLHDPPDGALD
IDLLPGVASPHLGIPWD--GKAPCQQVLAHLAQLTVPSNFTALSFFVGFMDSHREDIPDY
EVLMGPLHSLLKQKPDWQWDREHEKAFLALKRALVSALCLTAPDSQLPFHLEVTVSQVAL
TAILHQEHSGRKHPVAYTSKPLLPDEDSEGPQSGGDSPYAVAWALKHFSRWIGDTPVVLD
LSYASRPTVDPEAREGRRVSKAWLIRWSLLVQDKGKRDLELTLLQGLRGENRLLTPA-SS
MPRFFQALPPFSDLSTFVCIHMAGYCFYRDDEWCAGFGLYVLSPNSPPVSLSFSCSPYTP
TYAHLAAVACGLERFGHSPFPVVFLTHCHWIFNLLWELLPLWKVRGF-LSSDGAPLPHPS
LLSYIIDLTSGLPSLPFIYRTSYRGSLFAVTVDNLAKQGAQGGGECWNLPKDVPAP-VVT
PHGPGSRPNLLALQLADSTLAEIIAKLQAGQKLSGCSPFSPAFNFLSLDEETGMLLFKGE
KKPRVWVVPRQLRRDLIFSVHDVPMGGHQRPEETYKKLRLLGWWPGMQEHVRDYCRSCLF
CIPRHLVGSELKVIESPW---P--LRS--TAPWSNLQIEVVGPITVSEEGHKHVLIVADP
NTRWVEAFPLKPYTHMAVAQVLLQHVFARWGVPVRLEAAQGPQFARHVLVSCGLALGAQV
TTLSRDLQFPGLASSEAYWEFKRALKEFIFLHGRKWAASLPLLHLAFRASSADASPFQVL
TGGEMRLSEPLWWQMSSANLEGLKMDVFLLQLTGELLELHWRGADKASSK---SENRRFQ
RESQEKEWNVGDQVLLLSLPRNGSSAKWVGPFYIGDRLSLSLYRVWGFPTPEKLGCIYPS
SLMKAFAKSGTPLSFKVLEQ----

------------------------------------------------------------
--------------------------------------------------------MPTW
-EARPA--SPDRFAVSAEA-ENKVREQQPHVKRIFSVGVSVLP---------KDCPDNPH
IWLQLEGPKENASRAKEYLKGLCSPELQDEIHYPPKLHCIFLGAQGFF-LDCLAWSTSAH
----------L---VPRAPGSLMISGLTEAFVMAQSRVEELTERLNWDFTPGPSSGASQC
TGVLRDFSALLQSPGDAHREALLQLPLAVQEELLSLVQEASSGQGPGA----LASWE-GR
S----S-------GLLGAQC--Q----EERAP-PSDG----RESLD------TGSVGPRD
SR------------------------------------------GAR--GDN--------
----------------------------------Y----AVGKEGGKQGGPREM----DL
GWKELPGE-------------------------------------EAWERE------VAL
R-----------PQSVGG----------------------------------GL-RES--
-----APL-KGKALGKEEVT----------------QGGGG-LYVHRE---PPGAHGSCH
RAA-----------------------------------------QSRGASLLQRLHN--G
NASPPRV-----------------------------------------------------
-------------PSPPPA-----------------------------------------
--------------PEPPWHCGDRGDWGDRGDGGDR------------------------
------------------------------------------------------------
------GDK----------QQG---------------MARGRG----P--Q---------
--------------------------WKRG------ARG-----G-NLVTGTQRFKEALQ
DPFTLCLANVPGQPDLRHIVIDGSNVAMVHGLQHYFSSRGIAIAVQYFWDRGHRDI----
TVFVPQWRFSKDSKVRESHFLQKLYSLSLLSLTPSRVMDGKRISSYD-------DRFM-V
KLAEETDGIIVSNDQFRDLAEESEKWMAIIRER---------------------------
LLPFTFVGNL------FMVPDDPLGRNGPTLDEFLKKPART-QGSS-KAQHPSRSFAEHG
----------------------------------KQQ-----------------------
---------------H--G-REEEKGSGG--IRKTRETERLRRQLLEVFWGQDHKV---D
FIL---------------QREPYC-RDINQLSEALLSLNF--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
--------------------------------------------------------MLL-
--SGGDPPAQEWFMVQTKS-KPRVQRQRLQVQRIFRVKLNAFQ----------SRPDTPY
FWLQLEGPRENMGKAKEYLKGLCSPELWKEVRYPPILHCAFLGAQGLF-LDCLCWSTLAY
----------L---VPGPPGSLMVGGLTESFVMTQNWLEELVGRLRWGPAPLLTPRGIWE
AEVTRAFGALVWIRGDQHAGDLLQLPPAVQELLLSLVRDAAGKEDI-IQWLSRFGISNTH
---SNP-------EVLI-------------------------------------------
-CPPQQKKEGSAVVSMGESPG---HFLDVGTPK-----NGGLDK--SKRISSVGATRALV
---------PAQSTQQ----------ETAAQLVRVVSNNQ---GG-TDSAREEGP---VQ
ATSSQDSANHTKA--------LLQQRQVQRVEDK--SSFQP--PVSALGVCPPWKAWTPG
QA--------FGPLWPGA------IAATFWRIN---ELHS----LHLAWLLSQAYFNFPF
WQ-RPLGPIQLKLPGQNPLPLNLEWKQKELAPLPCAESPACRPDGGLG---REAALQSCL
RTETPP-KVMSLLVVPGGSGVKGKVSPGLPQIGPPLTSTSQLQTGGEPGDQGG-MQLDCK
GLEEGPSPTLPMG------------QEKPMTQGELTAWSVPEAQTVPETFKVPVAAAVPK
AENPSRTQVLPAAPEVPTVQRMPA-VHAEPAAPQVPS-----------------------
-------------APAKP------AAQGVAT-AQKAATGQLAS----TTQVVPTTPKTPM
AQRMPV---AKTSPASPKTPKSQTGLAAET--------------------------ESAA
PKLSRAPKT--------PAARKESTDAGLTLDVAKLLSEVQPLARGSASLPKGRGEA-GK
QGPQPNSTSALSGKHPSQVEGLLGP-WEGAPRQPPRHLQ-----ANSTVTSFQRYHEALN
TPFELNLSGEPGNQELRRVVIDGSSVAMVHGLQHFFSCRGIAMAVQFFWNRGHREV----
TVFVPTWQLKKNRRVRESHFLTKLHSLKMLSITPSQLENGKKITTYD-------YRFM-V
KLAEETDGIIVTNEQIHTLMNNS-KKLMV-KDR---------------------------
LLPFTFAGNL------FMVPDDPLGRDGPTLDEFLKKPNRLDTDIGNFLKV----WKTLP
PSSACISELNDE-VDVGPPECSKNVAEIREQKEERQDE---V-----------H------
--RGGQDM--------WKLA-EEDNLDASLASVFRVECPSLSEEILRCLSLHDPPDGALD
IDLLPGAASPYLGIPWD--GKAPCQQVLAHLAQLTIPSNFTALSFFVGFMDSHQDVIPDY
EALVGPLHSLLKQKPDWQWDREHEKAFLALKRALVSALCLTAPNSQLPFLLEVTVSQVAL
TAILHQEHSERKHPIAYTSKPLLPDEESEGPQSGGDSPYAVAWALKHFSRCIGDTPVVLD
LSYASRTTVDPEAPEGRRVSKAWLIRWSLLVQDKGKRALELSLLQGLLGENRLLTPA-SS
MPRFFQVLPPFSDLSMFVCIHMSGYCFYREDEWCAGFGLYVLSPTSPPVSLSFSCSPYTP
TYAHLAAVACGLERFGQSHLPVVFLTHCNWIFSLLWELLPLWRARGF-RSSDRAPLPHPS
LLSYIISLTSDLSSLPFIYRTSYRGSLFAVTVDTLAKQGAQGGGQWWSLPKEVPVP-VVT
PHTMGKRPNLLALQLGDSTLAEIIAKLQAGQKLSGSSPFSSAFNSLSLDKESGLLMFKGD
KKPRVWVVPTQLRRDLIFSVHDIPLGAHQRPEETYKKLRLLGWWPGMQEHVRDYCRSCLF
CIPRNLIGSEMKVIESPW---P--LRS--TAPWSNLQLEVVGPVTISEEGHKHVLIVADP
NTRWVEAFPLKPYTHMAVAQVLLQHVFARWGVPVRLEAAQGPQFARHVLVSCGLALGAQV
VSLSRDLQFPCLTSSGAYWEFKRALKEFIFLHGKKWAASLPLLHLAFRASSAEATPVQVL
TGGEVRLTKPLWWEMSSANIEGLKMDVFLLRLVGELLELHWRAADKAGEK---AENRRFR
QESQEKEWNVGDQVLLLSLPRNGSSAKWVGPFYIGDRLSLSLYRVWGFPTPEKLGCIYPS
SMMKAFAKSGTPLSFKVLEQ----

------------------------------------------------------------
--------------------------------------------------------MLL-
--VGGEPPAQEWVMVQTKS-KPRVQ-RRLQVQRIFRIKLNAFQ----------SRPDSPN
FWLQLEGPRENMGKAKEYLKGLCNPELWKEVRYPPALHCAFLGAQGLF-LDCLCWSTQAY
----------L---VPGPTGSLMVGGLTESFIMTQNWLEELVGRLRWGPAPVCTPRGIWE
AEVTRAFGALIWIRGDQYAGDLLQLPPAVQELLLSLVRDAAGKEDI-IEWLGRLGTSNAR
---SDP-------EVLI-------------------------------------------
-CPPQQQKEGSAMTSVGDGPG---PLLEMRTLQ-----NGNTEN--TKRLTSLGAS----
---------PGQKAQQ----------ETANQLVRVGSNSQ---GG-MDSAHREGP---VP
AAGSQDPANHSQA--------LAQQRQLQRVEDK--LSFQP--PVTTLGVCPSWKAWAPG
PA--------FGPLWPGT------IATTFWRIN---ELHS----LHLAWLLSQACFSFPF
WQ-RPLGPIQFKLPGQSPLPLNLEWKQKELVPLPSVESP----DGGPG---GEADLQNCP
RPETPP-KVMSLLVVSGGSGIKGKASPGLPQVGPPLTSTPQLQAGSELGDQGS-VQWDCK
GPEEGPLPAPPTGQGVPT------AQGRP-----PTAESVPDTQTVPETLEVPMAAAVPT
AQTPPQNQVLSAAPKVPTAQMMPA-DHTEPAALKVPS-----------------------
-------------APTKPAAPGG------PT-AQK----------AAVAQTVPATPKTPT
AQKIPA---AKTSPAGPKAPKAQTGPVAKTGSA--------------APKAPAAPK----
----AAPKT--------PAAQKALTDPGPAVDAAKLPREAQPSSRGSASSPKGQGEA-RR
QGLQPCSTVAPSSKHQPQVGGLLGA-SEGTPRQPPRQPQ-----ANSTVTSFQRYHEALN
TPFELNLSGEPGNQGLRRVVIDGSSVAMVHGLQHFFSCRGIAMAVQYFWNRGHREV----
TVFVPTWQLKKNRRVRESHFLTKLHSLKMLSITPSQLENGKKITTYD-------YRFM-V
KLAEETDGIIVTNEQLHILMNNS-KKLMV-KDRAHQ------------------------
---HLPSGDV------VLAPVRRPGSSGPSLPHCLWFPQVLDTDVGNFLKV----WKALP
PSSARISEQSDT-ANSGPLESPQKVEEEERQDEEPEL------RERQDE---EQ------
--REGQDTQ---RPA---EEEDQDSSLASLASVFKSECPTLSEEILRCLSLHDPLDEALD
IDLLPVVASPSLGIPWD--GKAPCQQVLAHLAQMTIPRNFTALSFFMGFMDSHREVIPDY
EALVGPLHSLLKQKPDWQWDQEHEKAFLALKRALVSALCLKAPDSQLPFYLEVMVSQVAL
TATVYQENSGRKHLIAYTSKPLLPDEESEGPQSGGDSPYAVAWALKHFSRCIGDIPVVLD
LSYAARTTVDPEAWEDRRLSKAWLIRWALLVQDKGKRALELTLLQGLLGKNRLLTPS-SS
LPRFFQILPPFSDLSTFVCIHMSGYCFYREDEWCAGFGLYVLSPTSPPVSLSFSCSPYTP
TYAHLAAVACGLERFSQSHYPVVFLTHCHWVFSVLWELLPLWRARGF-LSSDGSPLPHPS
LLSYIISLTSGLPSLPFIYRTSYRGSLFAVTVDNLAKEGAQGGGEFWNLPTDVPVP-IVS
PHTMGKRPNLLALQLSDSTLADVIAKLRAGQKLSNSSPFSSASNSLSLDQESGLLLFKGD
KKPKVWVVPRQLRRDLIFSVHDLPVGAHQRPEETYKKLRLLGWWPGMQEHVRNYCRSCLF
CIPRNLLGNELKVIESLW---P--LRS--TAPWSNLQIEVVGPVTVSEEGHKHVLIVADP
HTRWVEAFPLKPYTHMAVAQVLLQHVFARWGVPVRLEATQGPQFARHVLVSCGLALGAQA
TSLSRDLQFPCLTSSGAYWEFKRALKEFIFLHGKKWAASLPLLHLAFRASSPQATPFQIL
TGGQERLMGPLWWEMSSANIEGLKMDVFLLQLTGELLELHWRMADKVSEK---VENRRFK
RESQEKEWNVGDQVLLLSLPRNGSSAKWVGPFYIGDRLSLSLYRVWGFPTPEKLGCIYPS
SLMKSFAKSGTPLSFKLLEQ----

------------------------------------------------------------
--------------------------------------------------------MLL-
--AGGDPLAQEWFMVQTKS-KPRVQRQRPQVQRIFRVKLNAFQ----------NRPDKPY
FWLQLEGPRENIGKAKEYLKGLCSPELWKEVRYPPVLHCAFLGAQGLF-LDCLCWSTLAY
----------L---VPGPTGSLMVGGLTESFVMTQNWLEELVGRLRWGPAPLLTPRGIWE
AEVTRAFGALVWIRGDQHAGDLLQLPPAVQELLLSLVRDAAGTENI-LEWLGRVGISDTR
---SDP-------EALV-------------------------------------------
-CPPHRPKEGPAMVSMGESPG---PFLEMGTLQ-----NGGSED--SKRLTSLGVAGPLV
SGILGPQEISARNTQQ----------ETANQLVRVGSNNR---GG-TDSARQEGP---AQ
APGSKDSANHTQA--------LSKQRQVKRVEDK--LPFRVPVPVSALGVCPPWKAWSPG
PA--------FGPLWPGA------IATTFWRIN---ELHS----LHLAWLLSHACFNFPF
WQ-RPLGPIQFKLPGQNPLPLNLEWKQKELSPLPSVEGPACRPDGGLG---GEEALQNCP
RPETPR-KVLSLVVVPGGLAIKDRVSPGLPQIGPPPTSTPQLQAGAEPGDQGT-RQWDCK
GLKEERLPALPAGQGM------PTAQGEPSAHGGLTTPLVPEAQRVPETRKVPMAAAAPA
PVPPVQ--QSATTQKLPAAQKMPS-AQTTPVGPKGPT-----------------------
-------------AHEVPSAPMT-AAQVVPT-APKAAVAPPTS----PVQKVSATPKVPA
AQKTPA---TKTSPAGPKTPKAQNVSTARSG--------------ASTPKAPAAPKAPAV
SKGSRAPQM--------PAAQKVPTEPTASLDE--------------AKLPKGQGEA-GR
QGPQPSSTLGPSSKHQPQGDGLLGA-WEGAPRQSPHHPQ-----MNSTVTSFQRYHEALN
MPFELSLSGEPGNQGLRRVVIDGSSVAMVHGLQHFFSCRGIAMAVQYFWNRGHREV----
TVFVPTWQLKKNRRVRESHFLTKLHSLKMLSITPSQLENGKKITTYD-------YRFM-V
KLAEETDGIIVTNEQIHVLMNNS-KKLMV-KDR---------------------------
LLPFTFAGNL------FMVPDDPLGRDGPTLDEFLKKPNRLDTDIGNFLKA----WKTLP
PSSAGGSELGGA-AAAGPPESPRSVDDVEEAAERQAPAQGAVQGAAQGA---EQ------
--GAEQGAE---QGAEQGAAHGPPHLHPSPASPLHAECPSLSEEVLQCLSLHDPSDGAPD
IDLLPGVASPYPGVPWD--GKAPCQQVLAHLAQLTIPSNFTALSFFVGFMDSHRDAIPDY
EALVGPLHSLLKQKPAWQWDREHEEAFLALKRALVSALCLMAPDPQLPCRLDVAVSRAAL
TATLYQEHSGRKHPVAYTSKPLLPDEEGEGPQSGGDSPYAVAWALKHFARCVGDTPVVLG
LSYAARAAVDPEAREGRGVSEAWLIRWSLLVQDKGKRALELALLQGLLGENHLLTPA-AA
MPRFFQALPPFSDLSTFVCVHMSGYCFYREDEWCAGFGLYVLSPTGAPVSLSFSCSPHTP
TYAHLAAVACGLERFGQSSFPVVFLTHCNWIFSLLWELLPLWRARGF-LSSDGAPLPHPS
LLSYIISLTSSLPSLPFIYRTSYRGSLFAVTVDTLAKQGAQGGGQWWNLPKDVLAP-SVT
PRSLGQRPNLLALQLSDSTLAEVIAKLQAGQKLPSSSPFSSAFNSLSLDKESGLLMLKAD
KKPRVWVVPKQLRRDLIFSVHDLPVGAHQRPEETYKKLRLLGWWPGMQEHVRDYCRSCLF
CIPRNLMGSELKVIESPW---P--LRS--NAPWSNLQIEVVGPVTTSEEGHKHVLIVADP
HTRWVEAFPLKPYTHMAVAQVLLQHVFARWGVPVRLEAAQGPQFARHVLVSCGLALGAQA
VSLSKDLQFPCLTSSGAYSEFKRALKEFIFLHGKRWAASLPLLHLAFRASSAEATPFQVL
TGSELRLPEPLWWEMSSANIEGLKMDIFLLQLIGELLEFHWRVADRVSEK---VGNRHFK
RESQEKEWNVGDQVLLLSLPRNGSSAKWVGPFYIGDRLSLSLYRVWGFPTPEKLGCIYPS
SLMKAFAKSGTPLSFKVLEQ----

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MGGKSLPTSSALCHSGSLQ
PLSGMSVLGHVSPHGASNPRLPAAGGLAEPSHAPD-RGRGAAKRLGRDSFPPSKSRGVPE
TKVNRASQALLVGREDEHSGALLRLPLAIQEELLRLVQEAVKDGGD-AEWMGPLEPPLDG
SSRSRP-------GKIS-----AKPLLELRTLQ---------RGQYCGSRGEPGKVSQTE
ERPDQIIREGSTVLELGGRSRGKRVYREIPNLIPHCRGNKRPVNSPSFREEMLGLIRQVL
GDGLSPLTLTGPSNSASASKAQGSPKPSSVPRLRWGDNSSKRKEDPHGRSSEEGPE--P-
PRVSFPSENHTKLRSAQIREVGLAQKQLHNLEAKAALKSQVTMPFASWKNVSFPGTWGQG
SP--------CRPLWLGPPQHCGVGHSTFWRVQ---DGHS----SPLPWGLDWG-RNLPH
NQLRQAAPLKYKLQAQSPFPVRLEWKNRPLLRDPILVPPSCNPGWWQV---LKTAPQMCQ
RPVTLT---------PGGYDVCS----G------------SLQRGSLVGDWEPGLL--PT
WLHEPRLVTTFTEQG---------------------------------------------
----PVQELVSPFPEMSLAR----------------------------------------
-------------------------AEILTDILRDVSCGQ--------------------
-------------PYGPVPVS--------------------------------LLKYFGE
PERQRQVNC-------QP---IHCFTAGPVF------REKQRK---KNKCP---------
--------------------KVVG----SEQHVPFVHPQ-----VNNLVTSFQRFHEALS
VPFSLSLENIPGKPGLRHVIIDGSNVAMVHGLQHFFSCRGIALAVQYFWDRGHREI----
TVFVPNWRLRKNSRVREGHYLTKLHSLSLLSITPSRFVDGKRVTSYD-------DRFM-V
KLSEETDGVIVTNDQFRDLVDESKKWIGIIRER---------------------------
LLPFTFVGNI------FMVPDDPLGRDGPTLDTFLRRTDGLELAVSNFLRV----WEKKP
PTKAPFLPIKAKGL--------QGNKHLKKGCSGPQ-----------------QK---EK
-------VKKLTEGVEKLMTKEEDSLDTCLSTVFREECPFLSDDILRYFSLQDNTS---E
TSLSPWTGSSQLDIPWSRAGQPTCQRVLDHLAQLTVPTSFSALSFFVGFMGCHKDVIPRY
ASLVAPLHGLLKKKTQWQWTPEHSQAFLALKQALVSALSLVPPDPQLPYRLEVAVSEKTL
AAVLTQERAGLRRPIAYTSKPLLPQEGKAALS-RGGGLCALAWAVRRFAPSLGSVPVVLE
ASYTSRDSPDPEQRESLDSSDTWLARWSLLVQDKDRRTLGTSFLPGPLGDSGLPMPTPDS
LPQFFQILPPFSDLSSFVCIYTSGYCFYQDTEWCAGFGLYVLSPDSPPLSLSFSCSPHTP
TYAHLAAVACGLERFVHSCIPLVFLVNCSWLFNILIDLLPLWHSRGF-LSSDGAPLPHPA
LLSYITSLASSLPTLPFLFKASYKGALFSVTVEALAKQGAQGSSPLWKLPKHIAPSVGVA
ASPLGDGPNLQALQETDAVLLEAICQLQAGRRLPGHSPLKPFEPGISFVKECNLLMYREM
KRPKVWIVPEQIRKDLIYSVHDVPPGPHADPEETLRRLRRLGWWPKMHGQVRAYCKSCLF
CTSVSSLTQEAKCLRTQWSSA-------AAAPWSSLRIDVIGPVPASEEGHRHVLIASDA
CSSWTEAFPLKSFTQMAVAQVLLQQVFSRWGVPVRLEAAQGSQFARHVLMSCGVVLGAKL
GRISGDIQPAELRDGGSTQAFKSSLREFITLHGKNWASCLPLLHMAFRAPESGPTPFAVV
TGSEMRLAESLWWELSGAHVEGLKMDVFLQQLKSNVLESHLQAALASGDPPGLEHSGYFQ
QEVQGKEWNVGDQVLLLNFSKPG-AARWVGPYYIVDRLSLSLYRVWGYPTPGKLGVTYPT
NLMKSYPQGGAPLPSVILEQLE--

------------------------------------------------------------
--------------------------------------------------------MLL-
--SGGDPPAQEWFMVQTKS-KPRVQRQRLQVQRIFRVKLNAFQ----------SRPDTPY
FWLQLEGPRENMGKAKEYLKGLCSPETWKEVRYPPILHCAFLGAQGLF-LDCLCWSTLAY
----------L---VPGPPGSLMVGGLTESFIMTQNWLEELVGRLRWGPAPLLTPRGIWE
AEVTRAFGALVWIRGDQYAGDLLQLPPAVQELLLSLVRDAAGKEDI-IEWLSHFGISDTH
---SDP-------EVLI-------------------------------------------
-CPPQQQKEGPAMVSIGESPG---PFLEMGTLQ-----NGGPEK--SKRLTSVGASTSLI
---------PAQSTQQ----------EAANQLVRVSSDNQ---NG-MDSAQEEGP---AQ
ATSSQDSGNHTQA--------LLQQRQVQRVEDK--LPFQT--PVSALGVCPPWKAWTPG
PA--------FGPLWPGA------IAATFWRIN---ELHS----LHLAWLLSQACFSFPF
WQ-RPLGPIQLKLPGQNPLPLNLEWKQKELAPLPSAGSPACGPDQVLG---GEAALQNCP
RSESPS-KVMSLLVVPGGLSVKDKVSPGLPQIGPPLTSTPQLQAGSEPGDQGS-MQTDCK
ELKERPCPEPPMGQ------------GKP-----MTAPSVPEAQTVPEILKVPVAAAVSK
AENPHTTQGLPAAHKVPTPVMMLA-VHTEPVAPKVSS-----------------------
-------------APTKPA------SQVVPT-AQKVAVGQLAS----GDQGVPRTPKTPT
AQKLPA---AKTSPAGTKTPKAQTGPTAKTGST--------TPKTPTAPKAPAAPKASAA
PKASRTPKT--------PVAQKRSTEAGATLDVAKLLSEVQPSSRGSASFPK--------
-GPQASSTLVLSSKHQFQMEGLLGAPWEGAPRQSPRHPQ-----ANNTVTSFQRYHEALN
TPFELNLSEEPGDQGLRRVVIDGSSVAMVHGLQHFFSCRGIAMAVQFFWNRGHREV----
TVFVPTWQLKKNRRVRESHFLTKLHSLKMLSITPSQLENGKKITTYD-------YRFM-V
KLAEETDGIIVTNEQIHILMNNS-KKLLV-KDR---------------------------
LLPFTFAGNL------FMVPDDPLGRDGPTLDEFLKKPNRLDTDIGNFLKV----WKTLP
PSSARVSELTDDAADPEPLKSPQKFEEIMEKEERRDEE---------------Q------
--RESQGKLK---------PAEEDDLDSSLASVFGVESPSLSEEILRCLSLHDPPDGALD
IDLLPGVASPYLGIPWD--GKAPCQQILAHLAQLTVPSNFTALSFFVGFMDSHRDVIPDY
EGLVGPLHSLLKQKPDWKWDREHEKAFLALKRALVSTLCLTAPNPQLPFLLEVTVSQVAL
TAILHQEHSGRKHPIAYTSKPLLPDEESEGPQSGGDSPYAVAWALKHFSRCIGDAPVVLD
LSYASRTTVDPEAREGRRVSKAWLIRWSLLVQDKGKRALELTLLQGLLGENRLLTPA-SS
MPRFFQVLPPFSDLSTFVCIHMSGYCFYREDEWCAGFGLYVLSPTSPPVSLSFSCSPYTP
TYAHLAAVACGLERFGQSPLPVVFLTHCNWIFSLLWELLPLWRARGF-LSSDGAPLPHPS
LLSYIISLTSGLSSLPFIYRTSYRGSLFAVTVDTLAKQGAQGGGQWWSLPKDVPVP-VVT
PHAVGKRPNLLALQLSDSTLADIIAKLQAGQKLPGSSPFSSAFNSLSLDKESGLLMFKGD
KKPRVWVVPRQLRRDLIFCVHDIPLGAHQRPEETYKKLRLLGWWPGMQEHVRDYCRSCLL
CIPRSLTGSEVKVIESPW---P--LRS--TAPWSTLQIEVVGPVTVSEEGHKHVLIVADP
NTRWVEAFPLKPYTHTAVAQVLLQHVFARWGVPIRLEAAQGPQFARHVLVSCGLALGVQV
ASLSRELQFPCLTSSEAYWEFKRALKEFIFLHGKRWAASLPLLHLAFRASSSEPSPFRVL
TGAELRLAEPLWWEMSSANIEGLKMDVFLLQLVGELLELHWRVADKAGEK---AENRRFK
RESQEKEWNVGDQVLLLSLPRNGSSAKWVGPFYIGDRLSLSLYRVWGFPTPEKLGCIYPS
SLMKAFAKSGTPLSFKVLEQ----

------------------------------------------------------------
--------------------------------------------------------MLL-
--SGGDPPAQEWFMVQTKS-KPRVQRQRLQVQRIFRVKLNAFQ----------SRPDTPY
FWLQLEGPRENMGKAKEYLKGLCNPELWKEVRYPPILHCAFLGAQGLF-LDCLCWSTLAY
----------L---VPGPPGSLMVGGLTESFIMTQNWLEELVGRLRWGPAPLLTPRGIWE
AEVTRAFGALVWIRGDQHAGDLLQLPPAVQELLLSLVRDAAGKEDI-IEWLSRFGISDSH
---SDP-------EVLI-------------------------------------------
-CPSQQQKEAPAMVSVGESPG---PFVDMGTLQ-----NRVPEN--SKRLSSLGATGSLI
---------PAQSTPQ----------EAANQLVRVGSNSQ---GG-MDSAQEEGP---VQ
ATSSQDSTNHTQA--------LLKQKQVQRIEDK--LLFQP--PVSALGVCPSWKAWTPG
PA--------FGPLWPGA------IAATFWRIN---ELHS----LHLAWLLSQACFNFPF
WQ-RPLGPIQLKLPGQNPLPLNLEWKQKELAPLPSAESPAGRPDGGLG---GEAALQNCP
RPEIPP-KVTSLLVVPGSSDVKDKVSSDLPQIGPPLTSTPQLQAGGESGDQGS-MQLDCK
GLEEGPAPVLPAG------------QGKPMAQGELTDQSVPGAQTVPETLKVPMAAAVPK
AENPPRTQVPPAAPKVPTSQVMPA-VHTEPAAPKVPS-----------------------
-------------APTKP------AAQMMAT-AQKTVVNQPVL----AAQVEPTTPKTPQ
AQKMPV---AKTSPAGPKTPKAQAGAAATVSKAPAASKA------------PAAPKVPVT
PKVSRAPKT--------PAAQKVPMDAGPTLDVAKLLSEVQPTSRASASLLKGQGQA-GR
QGPQPSGTLALSSKHQFQMEGLLGA-WEGAPRQPPRHLQ-----ANNTVTSFQRYHEALN
TPFELNLSGEPGNQGLRRVVIDGSSVAMVHGLQHFFSCRGIAMAVQFFWNRGHREV----
TVFVPTWQLKKNRRVRESHFLTKLHSLKMLSITPSQLENGKKITTYD-------YRCAHG
KLAEETDGIIVTNEQIHILMNNS-KETDG-QRSRLEPFLPLGCQAAPGMESL--------
-LPFTFCGES------LHGL---LRMGLP--SLFHLFWCRLDTDIGNFLKV----WKTLP
PSSASVTELSDD-ADSGPLESPPNMEEVREEKEERQDE---E-----------Q------
--RQGQGM--------QEAA-EEDDLDSSLASVFRVECPSLSEEILRCLSLHDPPDGALD
IDLLPGAASPYLGIPWD--GQAPCQQVLAHLAQLTIPSNFTALSFFVGFMDSHRDAIPDY
AALVGPLHSLLKQKPDWQWDQEHEEAFLALKRALVSALCLTAPNSQLPFRLEVTVSHVAL
TAILHQEHSGRKHPIAYTSKPLLPDEESQGPQSGGDSPYAVAWALKHFSRCIGDTPVVLD
LSYASRTVVDPEVREGRRFSKAWLIRWSLLVQDKGKRALELALLQGLLGENRLLTPA-AS
MPRFFQVLPPFSDLSTFVCIHMSGYCFYREDEWCAGFGLYVLSPTSPPVSLSFSCSPYTP
TYAHLAAVACGLERFGQSPLPVVFLTHCNWIFSLLWELLPLWRARGF-LSSDGAPLPHPS
LLSYIISLTSGLSSLPFIYRTSYRGSLFAVTVDTLAKQGAQGGGQWWSLPKDVPAP-TVT
PHAMGKRPNLLALQLSDSTLADIIARLQAGQKLSGSSPFSSAFNSLSLDKESGLLMFKGD
KKPRVWVVPTQLRRDLIFSVHDIPLGAHQRPEETYKKLRLLGWWPGMQEHVRDYCRSCLF
CIPRNLIGSELKVIESPW---P--LRS--TAPWSNLQIEVVGPVTISEEGHKHVLIVADP
NTRWVEAFPLKPYTHTAVAQVLLQHVFARWGVPVRLEAAQGPQFARHVLVSCGLALGAQV
ASLSRDLQFPCLTSSGAYWEFKRALKEFIFLHGKKWAASLPLLHLAFRASSTDATPFKVL
TGGESRLTEPLWWEMSSANIEGLKMDVFLLQLIGELLELHWRVADKASEK---AENRRFK
RESQEKEWNVGDQVLLLSLPRNGSSAKWVGPFYIGDRLSLSLYRIWGFPTPEKLGCIYPS
SLMKAFAKSGTPLSFKVLEQ----

------------------------------------------------------------
--------------------------------------------------------MPTW
-EARPA--SPDRFAVSAEA-ENKVREQQPHVERIFSVGVSVLP---------KDCPDNPH
IWLQLEGPKENASRAKEYLKGLCSPELQDEIHYPPKLHCIFLGAQGFF-LDCLAWSTSAH
----------L---VPRAPGTLMISGLTEAFVMAQSRVEELTERLSWDFTPGPSSGASQC
TGVLRDFSALLQSPGDAHREALLQLPLAVQEELLSLVQEASSGQGPGA----LASWE-GR
S----S-------GLLRAQC--Q----EERAL-PSDG----RESLD------TGSVGPRD
SR------------------------------------------GAR--GDN--------
----------------------------------Y----VVEKEGGKQGGPREM----DL
GWKELPGE-------------------------------------EAWERE------VAL
R-----------PQSVGG----------------------------------GL-RES--
-----APL-KGKALGKEEVT----------------QGGGG-VCVHRE---PPGAHGSCH
RAA-----------------------------------------QSRGASLLQRLHN--G
NASPPRV-----------------------------------------------------
-------------PSPPPA-----------------------------------------
--------------PEPPWHCGDRGDWGDRGDGGDR------------------------
------------------------------------------------------------
------GDK----------QQG---------------MARGRG----P--Q---------
--------------------------WKRG------ARG-----G-NLVTGTQRFKEALQ
DPFTLCLANVPGQPDLRHIVIDGSNVAMVHGLQHYFSSRGIAIAVQYFWDRGHRDI----
TVFVPQWRFSKDSKVRESHFLQKLYSLSLLSLTPSRVMDGKRISSYD-------DRFM-V
KLAEETDGIIVSNDQFRDLAEESEKWMAIIRER---------------------------
LLPFTFVGNL------FMVPDDPLGRNGPTLDEFLKKPART-QGSS-KAQHPSRGFAEHG
----------------------------------KQQ-----------------------
---------------H--G-REEEKGSGG--IRKTRETERLRRQLLEVFWGQDHKV---D
FIL---------------QREPYC-RDINQLSEALLSLNF--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
--------------------------------------------------------MLL-
--SGGDPPAQEWFMVQTKS-KPRVQRQRLQVQRIFRVKLNAFQ----------SRPDTPY
FWLQLEGPRENMGKAKEYLKGLCNPELWKEVRYPPILHCAFLGAQGLF-LDCLCWSTLAY
----------L---VPGPPGSLMVGGLTESFIMTQNWLEELVGRLRWGPAPLLTPRGIWE
AEVTRAFGALVWIRGDQHAGDLLQLPPAVQELLLSLVRDAAGKEDI-IEWLSRFGISDSH
---SDP-------EVLI-------------------------------------------
-CPSQQQKEAPAMVSVGESPG---PFVDMGTLQ-----NRVPEN--SKRLSSLGATGSLI
---------PAQSTPQ----------EAANQLVRVGSNSQ---GG-MDSAQEEGP---VQ
ATSSQDSTNHTQA--------LLKQKQVQRIEDK--LLFQP--PVSALGVCPSWKAWTPG
PA--------FGPLWPGA------IAATFWRIN---ELHS----LHLAWLLSQACFNFPF
WQ-RPLGPIQLKLPGQNPLPLNLEWKQKELAPLPSAESPAGRPDGGLG---GEAALQNCP
RPEIPP-KVTSLLVVPGSSDVKDKVSSDLPQIGPPLTSTPQLQAGGESGDQGS-MQLDCK
GLEEGPAPVLPAG------------QGKPMAQGGLTDQSVPGAQTVPETLKVPMAAAVPK
AENPPRTQVPPAAPKVPTSQMMPA-AHTEPAAPKVPS-----------------------
-------------APTKP------AAQMMAT-AQKTVVNQPVL----AAQVEPTTPKTPQ
AQKMPV---AKTSPAGPKTPKAQAGAAATVSKASAASKA------------PAAPKGPVT
PKVSRAPKT--------PAAQKVPMDAGPTLDVAKLLSEVQPTSRASASLPKGQGQA-GR
QGPQPSSTLALSSKHQFQMEGLLGA-WEGAPRQPPRHLQ-----ANNTVTSFQRYHEALN
TPFELNLSGEPGNQGLRRVVIDGSSVAMVHGLQHFFSCRGIAMAVQFFWNRGHREV----
TVFVPTWQLKKNRRVRESHFLTKLHSLKMLSITPSQLENGKKITTYD-------YRFM-V
KLAEETDGIIVTNEQIHILMNNS-KKLM--VKDRL-------------------------
-LPFTFAGNL------FMVPDDPLGRDGPTLDEFLKKPNRLDTDIGNFLKV----WKTLP
PSSASVTELSED-ADSGPLESPPNMEEVREEKEERQDE---E-----------Q------
--RQGRGM--------QKAA-EEDDLDSSLASVFRVECPSLSEEILRCLSLHDPPDGALD
IDLLPGAASPYLGIPWD--GQAPCQQVLAHLAQLTIPSNFTALSFFVGFMDSHRDAIPDY
EALVGPLHSLLKQKPDWQWDQEHEEAFLALKRALVSALCLTAPNSQLPFRLEVTVSHVAL
TAILHQEHSGRKHPIAYTSKPLLPDEESQGPQSGGDSPYAVAWALKHFSRCIGDTPVVLD
LSYASRTMVDPEVREGRRFSKAWLIRWSLLVQDKGKRALELALLQGLLGENRLLTPA-AS
MPRFFQVLPPFSDLSTFVCIHMSGYCFYREDEWCAGFGLYVLSPTSPPVSLSFSCSPYTP
TYAHLAAVACGLERFGQSPLPVVFLTHCNWIFSLLWELLPLWRARGF-LSSDGAPLPHPS
LLSYIISLTSGLSSLPFIYRTSYRGSLFAVTVDTLAKQGAQGGGQWWSLPKDVPAP-TVT
PHAMGKRPNLLALQLSDSTLADIIARLQAGQKLSGSSPFSSAFNSLSLDKESGLLMFKGD
KKPRVWVVPTQLRRDLIFSVHDIPLGAHQRPEETYKKLRLLGWWPGMQEHVRDYCRSCLF
CIPRNLIGSELKVIESPW---P--LRS--TAPWSNLQIEVVGPVTISEEGHKHVLIVADP
NTRWVEAFPLKPYTHTAVAQVLLQHVFARWGVPVRLEAAQGPQFARHVLVSCGLALGAQV
ASLSRDLQFPCLTSSGAYWEFKRALKEFIFLHGKKWAASLPLLHLAFRASSTDATPFKVL
TGGESRLTEPLWWEMSSANIEGLKMDVFLLQLIGELLELHWRVADKASEK---AENRRFK
RESQEKEWNVGDQVLLLSLPRNGSSAKWVGPFYIGDRLSLSLYRIWGFPTPEKLGCIYPS
SLMKAFAKSGTPLSFKVLEQ----

MCVE--RARTPRAGRQTRGLARSARSAPWSRRGGGAQPPVGASGRGDG--AGRRARSRAP
----------SRPSP--GRSRADSALGQE-VTQEIVCVR---SGLERSPLGLGAAAMPTW
-EARPA--SPDRFAVSAEA-ETKVREQQPHVERIFSVGVSILP---------KDCPDNPH
IWLQLEGPKENTSRAKEYLKGLCSPELQDEIHYPPKLHCIFLGAQGFF-LDCLTWSTSAH
----------L---VPREPSSLMISGLTEAFVMAQSRVEELVERLSWDFLPGPSPGASQC
PGVLRDFSALLHSPGDAHREALLQLPLAVQEELLSLVQEASSGQGPGA----LASWE-GR
S----S-------GLLGAQC--Q----GVRAP-PSDG----RESLD------TGSVGPRE
SR------------------------------------------GAR--GDS--------
----------------------------------Y----TVE-KGGKQGGPREM----AF
GWKELPGE-------------------------------------EAWERD------VGL
R-----------PQSVGR----------------------------------GA-RES--
-----APL-KGKTLGKEEAT----------------QGGGG-VCVHRE---PPSAHGSCH
RAA-----------------------------------------QSRGASLLQRLHN--G
NASPPRV-----------------------------------------------------
-------------PSPPPA-----------------------------------------
--------------PEPPWHCGDRGDWGD---GGDR------------------------
------------------------------------------------------------
------GDK----------QQA---------------TARGRG----P--H---------
--------------------------WKRG------TRG-----G-NLVTGTQRFKEALQ
DPFTLCLANVPGQPDLRHIVIDGSNVAMVHGLQHYFSSRGIAIAVQYFWDRGHRDI----
TVFVPQWRFSKDAKVRESHFLQKLHSLSLLSLTPSRVMDGKRISSYD-------DRFM-V
RLAEEKDGIIVSNDQFRDLAEESENWMAIIRER---------------------------
LLPFTFVGNL------FMVPDDPLGRNGPTLDEFLKKPART-QGPS-KAQHPSRVFAEHG
----------------------------------KKQ-----------------------
---------------Q--G-REEEKGSGG--IRKTRETERLRRQLLEVFWGQDHKV---D
FIL---------------QREPYC-RDINQLSEALLSLNF--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
--------------------------------------------------------MPSW
-EAGCL--SPDRFAVSAEA-EQKVQQHQLHVERIFRVSMTVLP---------KDCPQNPH
IWLQLEGPKENASRAKEYLKGLCSPELQDEIHYPPKLHCVFLGARGFF-LDCLAWSTSAH
----------L---VPGAPGSLMISGLAEAFVMAQSRVEELVERLSWDFQLGPSLGASQS
AGVLRDFSALLQSWEDAHREALLQLPLAVQEELLSLVQEVSREQGPQA----L-PWD-GR
N----P-------GMLGAQC--Q----EVRTY-PSAG----RESLD------TGSMGQGD
SR------------------------------------------VVK--GDS--------
----------------------------------Y----AVKKEEGKQSRPREM----DL
GWKDLPRE-------------------------------------EDWEKD------VAF
R-----------PQLVGE----------------------------------GA-REL--
-----EPL-KGKALGKERVP----------------QERGG-VCVQGL---PPGAHGPYQ
RAA-----------------------------------------QPRGASLLQRLHN--G
QASPPRV-----------------------------------------------------
-------------PSPPPA-----------------------------------------
--------------PEPPWHCGDRADR------ADR------------------------
------------------------------------------------------------
------ADK----------QQA---------------GARGRG----S--P---------
--------------------------WKRG------TRG-----S-NLVTGTQRFQEALQ
DPFTLCLANVPGQPDLRHIVIDGSNVAMVHGLQHYFSSRGIAIAVQYFWDRGHRDI----
TVFVPQWRFSKDSKVRESHFLQKLYSLSLLSLTPSRVMDGKRISSYD-------DRFM-V
KLAEETDGIIVSNDQFRDLAEESEKWMAIIRER---------------------------
LLPFTFVGNL------FMVPDDPLGRHGPTLDEFLKKPART-QEIS-KAQKTSKGFAEHA
----------------------------------KQQ-----------------------
---------------Q--G-REEEKGSGG--IRKTRETERLRRQLLEVFWGQDHKV---D
FIL---------------QREPYC-RDINQLSEALLSLNF--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------MLHCAFLGAQGLF-LDCLCWSTLAY
----------L---VPGPPGSLMVGGLTESFTMTQNWLEELVARLRWGPAPLLTPRGIWE
AEVTRAFGALVWIRGDQYAGDLLQLPPAVQELLLSLVRDAAGKEDI-IEWLSHFGISNTC
---S-P-------VALR-------------------------------------------
-SPPQQQKEDSAMVSTGESPG---SFLEMGTLQ-----NGGPEN--PKRLSSLGATRSLI
---------PAQSTQQ----------ETANQVVRVGSNNQ---SG-TDSDREEGL---VR
ATSSQDSVNHTPA--------LLQQKQVQKVEEK--FPFQP--PVSALGVYPSWKAWAPG
PA--------FGPLWPGT------IAAAFWRIN---QLHS----LHLAWLLSQACFSLPF
WQ-RPLGPIQLKLPGQSALPLNLEWKQKELAPLPSAESPACRPDGELVYKSTETTLQNCP
RPETPP-KVMSLLVVPGGSGEKDKVSPRLPLLAS--TTQ--LQAGGERRNQGS-LQPDCM
WLEKGPYPASPTEQGVL------TAQGRPMAQGGLTAQSAPEAGTVPETLKVPMAAVVPK
AENPPLTQGQPAAPKVPTSQMMPA-VSTEPAA----------------------------
--------PKVPLAPTMP------TAQVVST-AQKAAVDQPAL--ASAAQVMSTTPKTAM
AQKMLA---TKTSPASPKTLKAQTGPVTKMESA--APKASA------APKTSAAPKAPAA
SKASRAPQT--------PAVQKVPTGTGPTLDVARLLSEVQPSSKGDASLPKGQVEP-GR
QGVQSSSK-----------HQLLGG-WEGGPRQSPRHPQ-----VNSTVTSFQRYHEALN
TPFELNLSGEPGNQELRRVVIDGSSVAMVHGLQHFFSCRGIAMAVQYFWNRGHREV----
TVFVPTWQLKKNRRVRESHFLTKLHSLKMLSITPSQLENGKKIATYD-------YRFM-V
KLAEETDGVIVTNEQIHTLMNNS-KKLMV-KDR---------------------------
LLPFTFAGNL------FMVPDDPLGRDGPTLDEFLKKPNRLDTDIGNFLKV----WKTLP
PSSASISQLRDD-TDPRPLEGPQNVEEVREEKEERQDEEWR-------------------
---EGQG---------MPGWAEEDDLDSFLASVFRVECPSLSEEILQCLSLHDPPDGALD
IDLLPGVASSYLGIPWD--GKAPCQQVLAQLAQLTTPSNFTVLSFFVGFMDSHRDVIPDY
EALMGPLHSLLKQKPDWVWDQEHEKAFLALKRALVSALCLSAPNCQLPFRLQVTVSQVAL
TAILYQEHSGKKHPIAYTSKPLLPDEDSEGPQSGGDSPYAVAWALKHFSHCIGDDPVVLH
LVYASRTTVAPEAPECCRVSKAWLIRWSLLVQDRGKRALELALLQGLLGENRLLTPV-SS
MPRFFQVLPPFSDLSTFVCIHMSGYCFYREDEWCAGFGLYVLSPTSPPVSLSFSCSPYTP
TYAHLAAVACGLERCGQSHLPVVFLTHCNWIFSLLWELLPLWRARGF-LSSDGAALPHPS
LLSYIISLTSGLSSLPFIYRTSYRSSLFAVTVDNLAKQGAQGSGQWWDLPKDVPVP-VVT
SHTMGKRPNLLALQLSDSTLADIIAKLRAGQKLSVSSPFSSAFHSLSLDKESGLLMFKGD
KKPKVWVVPRQLRRDLIFSVHDIPMGAHQRPEETYKKLQLLGWWPGMQEHVKDYCRSCLF
CIPRNLTGSELKVIESPW---P--LRS--TAPWSNLQIEVVGPLTVSEEGHRHVLIVADP
NTRWVEAFPLKPYTHMAVAQVLLQHVFARWGVPVRLEAAQGPQFARHVLVSCGLALGAQV
TSLSRDLQFPCLVSSEAYWEFKRALKEFIFLHGRKWAASLPLLHLAFRASSTEATPFQVL
TGAERRLTEPLWWEMSSANIEGLKMDVFLLQLIGELLELHWRGAEKGTEK---ADNRRFK
QESQEKEWNVGDQVLLLSLPRNGSSAKWVGPFYIGDRLSLSLYRVWGFPTPEKLGCIYPS
SLMKPFAKSGTPLSFKVLEQ----

------------------------------------------------------------
--------------------------------------------------------MLL-
--SGGDPPAQEWFMVQTKS-KPRVQRQRLQVQRIFRVKLNAFQ----------SRPDTPY
FWLQLEGPRENMGKAKEYLKGLCNPELWKEVRYPPILHCAFLGAQGLF-LDCLCWSTLAY
----------L---VPGPPGSLMVGGLTESFIMTQNWLEELVGRLRWGPAPLLTPRGIWE
AEVTRAFGALVWIRGDQHAGDLLQLPPAVQELLLSLVRDAAGKEDI-IEWLSRFGISDSH
---SDP-------EVLI-------------------------------------------
-CPSQQQKEAPAMVSVGESPG---PFVDMGTLQ-----NRVPEN--SKRLSSLGATGSLI
---------PAQSTPQ----------EAANQLVRVGSNSQ---GG-MDSAQEEGP---VQ
ATSSQDSTNHTQA--------LLKQKQVQRIEDK--LLFQP--PVSALGVCPSWKAWTPG
PA--------FGPLWPGA------IAATFWRIN---ELHS----LHLAWLLSQACFNFPF
WQ-RPLGPIQLKLPGQNPLPLNLEWKQKELAPLPSAESPAGRPDGGLG---GEAALQNCP
RSEIPP-KVTSLLVVPGSSDVKDKVSSDLPQIGPPLTSTPQLQAGGESGDQGS-MQLDCK
GLEEGPAPVLPAG------------QGKPMAQGELTDQSVPGAQTVPETLKVPMAAAVPK
AENPPRTQVPPAAPKVPTSQMMPA-VHTEPAAPKVPS-----------------------
-------------APTKP------AAQMIAT-AQKTVVNQPVL----AAQVEPTTPKTPQ
AQKMPV---AKTSPAGPKTPKAQAGAAATVSKAPAASKA------------PAAPKVPVT
PKVSRAPKT--------PAAQKVPMDAGPTLDVAKLLSEVQPTSRASASLLKGQGQA-GR
QGPQPSGTLALSSKHQFQMEGLLGA-WEGAPRQPPRHLQ-----ANNTVTSFQRYHEALN
TPFELNLSGEPGNQGLRRVVIDGSSVAMVHGLQHFFSCRGIAMAVQFFWNRGHREV----
TVFVPTWQLKKNRRVRESHFLTKLHSLKMLSITPSQLENGKKITTYD-------YRFM-V
KLAEETDGIIVTNEQIHILMNNS-KKLM--VKDRL-------------------------
-LPFTFAGNL------FMVPDDPLGRDGPTLDEFLKKPNRLDTDIGNFLKV----WKTLP
PSSASVTELSDD-ADSGPLESLPNMEEVREEKEERQDE---E-----------Q------
--RQGQGM--------QKAA-EEDDLDSSLASVFRVECPSLSEEILRCLSLHDPPDGALD
IDLLPGAASPYLGIPWD--GQAPCQQILAHLAQLTIPSNFTALSFFVGFMDSHRDAIPDY
EALVGPLHSLLKQKPDWQWDQEHEEAFLALKRALVSALCLTAPNSQLPFRLEVTVSHVAL
TAILHQEHSGRKHPIAYTSKPLLPDEESQGPQSGGDSPYAVAWALKHFSRCIGDTPVVLD
LSYASRTMVDPEVREGRRFSKAWLIRWSLLVQDKGKRALELALLQGLLGENRLLTPA-AS
MPRFFQVLPPFSDLSTFVCIHMSGYCFYREDEWCAGFGLYVLSPTSPPVSLSFSCSPYTP
TYAHLAAVACGLERFGQSPLPVVFLTHCNWIFSLLWELLPLWRARGF-LSSDGAPLPHPS
LLSYIISLTSGLSSLPFIYRTSYRGSLFAVTVDTLAKQGAQGGGQWWSLPKDVPAP-TVT
PHAMGKRPNLLALQLSDSTLADIIARLQAGQKLSGSSPFSSAFNSLSLDKESGLLMFKGD
KKPRVWVVPTQLRRDLIFSVHDIPLGAHQRPEETYKKLRLLGWWPGMQEHVRDYCRSCLF
CIPRNLIGSELKVIESPW---P--LRS--TAPWSNLQIEVVGPVTISEEGHKHVLIVADP
NTRWVEAFPLKPYTHTAVAQVLLQHVFARWGVPVRLEAAQGPQFARHVLVSCGLALGAQV
ASLSRDLQFPCLTSSGAYWEFKRALKEFIFLHGKKWAASLPLLHLAFRASSTDATPFKVL
TGGESRLTEPLWWEMSSANIEGLKMDVFLLQLIGELLELHWRVADKASEK---AENRRFK
RESQEKEWNVGDQVLLLSLPRNGSSAKWVGPFYIGDRLSLSLYRIWGFPTPEKLGCIYPS
SLMKAFAKSGTPLSFKVLEQ----

------------------------------------------------------------
--------------------------------------------------------MPTW
-GAGSP--SPDRFAVSAEA-EDKVREQLPRVERIFRVGMSVLP---------KDCPENPH
IWLQLEGPKENASRAKEYLKGLCSPELQNEIHYPPKLHCIFLGAQGFF-LDCLTWSTSAH
----------L---VPGVPGSLMVSGLTEAFVMVQSRVEELVERLSWDFRLGPSPGASQC
AGVLREFSALLQARGDAHTEALLQLPQAIQEELLSL-QEASRGQGPQA----FLSWG-WG
G----P-------GPLGAQQ--Q----GVRTP-LGDS----GVSLD------TGPTGWQE
SR------------------------------------------GE-----R--------
----------------------------------H----AVEKEGTKQGGAREM----DL
GWKEWPGE-------------------------------------EAWERQ------VAF
R-----------PQSGG----------------------------------GEA-GQA--
-----GPP-KGKALGKEVVP----------------QERGR-LGVQGQ---PPGTQGPYQ
RAS-----------------------------------------QLRGASLLQRLHN--G
EASPPRV-----------------------------------------------------
-------------PSPPPA-----------------------------------------
--------------PEPPWHCGDRGDRGD------R------------------------
------------------------------------------------------------
------ADK----------QLV---------------VARGRG----G--P---------
-------------------------SWGRV------PSG-----G-QCSQAA--------
---------------------RSPLEGPWHGLQHYFSSRGIAIAVQYFWDRGHRDI----
TVFVPQWRFSKDSKVREGHFLHKLYSLSLLSLTPSRVLDGKRISSYD-------DRFM-V
KLAEETDGIIVSNDQFRDLAEESEKWMAIIRER---------------------------
LLPFTFVGNL------FMVPDDPLGRNGPTLDEFLKKPVRA-PGSS-KPQHSARGITEHS
----------------------------------NQ------------------------
--------------QP--GRKEEEKGNGG--IRKTRETERLRRQLLEVFWGQDHKV---D
FIL---------------QREPYC-RDINQLSEALLSLNF--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
--------------------------------------------------------MPTF
-GTGPP--IPDRFTVSAEA-EDKVRAEQARLERVFRVGVCVLP---------KDCPENPH
IWLQLDGSKENVSRAKEYLKGLCSPELQNEIHYPPRLHCIFLGAQGFF-LDCLAWSTSAH
----------L---VPGAPGSLRISGLTEAFVMAQSRIEELVERLSWDLGPGLYSTTSQN
AGVLRDFSALLQPREDAHTEALLQLPLAVQEELLSLVQEASTGHGPLA----LSSLE-QR
I----P-------GLLGALH--Q----EVRAP-LSEG----GESLG------AGYVGQGE
SR------------------------------------------GAS--GVS--------
----------------------------------H----TVEQNRGKQGGPREV----DL
GWKELLGE-------------------------------------EAWEKE------VTF
R-----------SQPAGG----------------------------------GV-GE---
-----MGYLKGMTCGMEGVP----------------RGRGG-FSVQGE---PPGAQGPCQ
RAA-----------------------------------------QSRGASLLQRLHN--G
EASPPRV-----------------------------------------------------
-------------PSPPPA-----------------------------------------
--------------PEPPWPCGDRGD------LGDR------------------------
------------------------------------------------------------
------GDK----------QQ-----------------GRGRG----S--S---------
--------------------------WKRG------TRG-----G-NLVTGTQRFQEALQ
DPFTLCLANVPGQPDLRHIVIDGSNVAMVHGLQHYFSSRGIAIAVQYFWDRGHRDI----
TVFVPQWRFSKDGKVREIHFLQKLYSLSLLSLTPSRVMDGKRISSYD-------DRFM-L
KLAEETSGIIVSNDQFRDLAEESDKWMAIIRER---------------------------
LLPFTFVGNL------FMVPDDPLGRNGPTLDEFLKKPARK-QVSS-KAQHPSKGFAGHG
----------------------------------NQQ-----------------------
--------------QGKE----EEKGSGG--IRKTRETERLRRQLLEVFWGQDHKV---D
FIL---------------QREPYC-RDINQLSEALLSLNF--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
--------------------------------------------------------MLL-
--SRGDPPAQEWFMVQTKS-KPRVQRQRLQVQRIFRVKLNAFQ----------SRPDTPY
FWLQLEGPRENMSKAKEYLKGLCSPELWKEVRYPPILHCAFLGAQGLF-LDCLCWSTLAY
----------L---VPGPPGSLMVGGLTESFIMTQNWLEELVGRLRWGPAPLLTPRGIWE
AEVTRAFGALVWIRGDQYAGDLLQLPPAVQELLLSLVRDAAGKEDI-IEWLGHIGTSDTL
---SDP-------ELLI-------------------------------------------
-CPPHQHKEGPAMVSVGEGPG---PLLEMGTLQ-----NGGPED--SKRLTSLGATGPLV
SGILGPQEISAQTKQQ----------ETANQLVRVGSNSQ---GG-TDNVLEEGP---VQ
TTSSQDSVNHTQA--------LSQLRQVQKVEDK--LSFQP--PVSALGVCPPWKAWSPG
PA--------FGPLWPGA------IAATFWRIN---ELHS----LHLAWLLSQACFNFPF
WQ-RPLGPIQFKLPGQNPLPLNLEWKPKELSPLPNVESPACGPDGGLG---GKVALQNCP
RPETSK-KVMSLLVVPGASGVKDRVSPGLAQIGLPSTTTPQLQAVGEPGDQGN-TEWDCK
EPKEGPLPVGLTGQRMPSAQERPLA---------MTAQSVLDAQTVPETLQVPMAAVVPM
AQKTPTTQMPPAAPKVPPAQLMPA-VHTAPAAHKVPS-----------------------
-------------TLTKPAA------QGLPT-AQKAAVGQMAP----TTQVVPTTPHTPT
TQKMPA---VKTSPAGPKMSKAQTVPAAKTGST--------------ASKAPAAPKAHTV
SKASRAPKT--------PAAQKAPPDSGPTLDVAKLLSEVQPSSKGGATFPKGQGEV-GR
QGPQPNHTLAPSSQHCPQMESLLGA-WEGAPRQPPRHPQ-----ANGTVTSFQRYHEALN
TPFELSLSGEPGDQGLRRVVIDGSSVAMVHGLQHFFSCRGIAMAVQYFWNRGHREV----
TVFVPTWQLKKNRRVRESHFLTKLHSLKMLSITPSQLENGKKITTYD-------YRFM-V
KLAEETDGIIVTNEQIHVLMNNS-KKLMV-KDR---------------------------
LLPFTFAGNL------FMVPDDPLGRDGPTLDEFLKKPNRLDTDIGNFLKV----WKTLP
SSSASISELSDD-ADPEPLESLQHVEEVKVEKERQDE---------------KL------
--REGHGIQ---RP------AEEDDCDSSLASVFGVECPSLSEEILRCLSLHDPPDGALD
IDLLPGGASPYLGIPWD--GKAPCQQVLAHLAQLTVPSNFTALSFFVGFMDSHRDVIPDY
EALVGPLHSLLKQKPDWQWGWEHEKAFLALKRALVSALCLMAPNSQLPFWLEVTVSKVAL
TATLYQEHSGRKHPIAYTSKPLLPDEDSEGPQSGGDSPYAVAWALKHFSRCIGDFPVVLD
LSYASRTSVDPKARQGCRVSKAWLIRWSLLVQDKGKRALELTLLQGLLGENRLLTPA-AS
MPRFFQVLPPFSDLSTFVCIHMSGYCFYREDEWCAGFGLYILSPTSPPVSLSFSCSPYTP
TYAHLAAVACGLERFGQSSLPVVFLTHCNWIFSLLWELLPLWRARGF-LSSDGAPLPHPD
LLSYIISLTSGLSALPFIYRTSYRGSLFAVTVDTLAKQGAQGGGQWWNLPKDVPVP-VVS
PRTKGKRPDLLALQLSDSTLADIIAKLQAGQKLPNSSPFASAFNSLSLDKESGLLMFKGD
KRPRVWVIPRQLRRDLIFSVHDLPMGAHQRPEETYKKLRLLGWWPGMQEHVREYCRSCLF
CIPRNLIGSELKAIESLW---P--IRS--TAPWSNLQIEVVGPVTISEEGHKHVLIVADP
NTRWVEAFPLKPYTHTAVAQVLLQHVFARWGVPVRLEAAQGSQFARHVLVSCGLALGAQA
ASLSRDLQFPCLTSSGAYWEFKRALKEFIFLHGKKWAASLPLLHLAFRASSTEATPSQIL
TGGEVKLAEPLWWEMSSANIEGLKMDIFLLQLIGELLDLHWRVADKASEK---AENRRFK
QESQEKEWNVGDQVLLLSLPRNGSSAKWVGPFYIGDRLSLSLYRVWGFPTPEKLGCVYPS
SLMKAFAKSGTPLSFKALEQ----

------------------------------------------------------------
--------------------------------------------------------MPTW
-GARPA--SPDRFAVTAEA-ENKVREQQPHVERIFSVGVSVLP---------KDCPDNPH
IWLQLEGPKENASRAKEYLKGLCSPELQDEIHYPPKLHCIFLGAQGFF-LDCLAWSTSAH
----------L---VPRAPGSLMISGLTEAFVMAQSRVEELAERLSWDFTPGPSSGASQC
TGVLRDFSALLRSPGDAHREALLQLPLAVQEELLSLVQEASSGQGPGA----LASWE-GR
S----S-------ALLGAQC--Q----GVRAP-PSDG----RESLD------TGSVGPGD
SR------------------------------------------GAR--GDT--------
----------------------------------Y----AVEKEGGKQGGPREM----DL
GWKELPGE-------------------------------------EAWERE------VAL
R-----------PQSVGG----------------------------------GA-RES--
-----APL-KGKALGKEEIT----------------LGGGG-FCVHRE---PPGAHGSCH
RAA-----------------------------------------QSRGASLLQRLHN--G
NASPPRV-----------------------------------------------------
-------------PSPPPA-----------------------------------------
--------------PEPPWHCGDRGDCGDRGDVGDR------------------------
------------------------------------------------------------
------GDK----------QQG---------------MARGRG----P--Q---------
--------------------------WKRG------ARG-----G-NLVTGTQRFKEALQ
DPFTLCLANVPGQPDLRHIVIDGSNVAMVHGLQHYFSSRGIAIAVQYFWDRGHRDI----
TVFVPQWRFSKDAKVRESHFLQKLYSLSLLSLTPSRVMDGKRISSYD-------DRFM-V
KLAEETDGIIVSNDQFRDLAEESEKWMAIIRER---------------------------
LLPFTFVGNL------FMVPDDPLGRNGPTLDEFLKKPART-QGSS-KAQHPSRGFAEHG
----------------------------------KQQ-----------------------
---------------Q--G-REEEKGSGG--IRKTRETERLRRQLLEVFWGQDHKV---D
FIL---------------QREPYC-RDINQLSEALLSLNF--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
--------------------------------------------------------MPTW
-EARPA--SPDRFAVSAEA-ENKVREQQPHVERIFSVGVSVLP---------KDCPDNPH
IWLQLEGPKENASRAKEYLKGLCSPELQDEIHYPPKLHCIFLGAQGFF-LDCLAWSTSAH
----------L---VPRAPGTLMISGLTEAFVMAQSRVEELTERLSWDFTPGPSSGASQC
TGVLRDFSALLQSPGDAHREALLQLPLAVQEELLSLVQEASSGQGPGA----LASWE-GR
S----S-------GLLRAQC--Q----EERAP-PSDG----RESLD------TGSVGPRD
SR------------------------------------------GAR--GDN--------
----------------------------------Y----AVEKEGGKQGGPREM----DL
GWKELPGE-------------------------------------EAWERE------VAL
R-----------PQSVGG----------------------------------GL-RES--
-----APL-KGKALGKEEVT----------------QGGGG-VCVHRE---PPGAHGSCH
RAA-----------------------------------------QSRGASLLQRLHN--G
NASPPRV-----------------------------------------------------
-------------PSPPPA-----------------------------------------
--------------PEPPWHCGDRGDWGDRGDGGDR------------------------
------------------------------------------------------------
------GDK----------QQG---------------MARGRG----P--Q---------
--------------------------WKRG------ARG-----G-NLVTGTQRFKEALQ
DPFTLCLANVPGQPDLRHIVIDGSNVAMVHGLQHYFSSRGIAIAVQYFWDRGHRDI----
TVFVPQWRFSKDSKVRESHFLQKLYSLSLLSLTPSRVMDGKRISSYD-------DRFM-V
KLAEETDGIIVSNDQFRDLAEESEKWMAIIRER---------------------------
LLPFTFVGNL------FMVPDDPLGRNGPTLDEFLKKPART-QGSS-KAQHPSRGFAEHG
----------------------------------KQQ-----------------------
---------------H--G-REEEKGSGG--IRKTRETERLRRQLLEVFWGQDHKV---D
FIL---------------QREPYC-RDINQLSEALLSLNF--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
--------------------------------------------------------MPTL
-GAGSS--TPDRFAVSAEA-EDKVREQQARLERIFSVGLSVLP---------KDCPENPH
IWLQLEGPKENVSRAKEYLKGLCSPELQNEIHYPSRLHCIFLGAQGFF-LDCLAWSTSAH
----------L---VPQAPGSLMISGLTEAFVMAQSRVEELVGRLSWDFQPGPCPRASQS
AGVLSDFSALLQPWEDVHSEALLQLPLAVQEELLSLVQEASSGQGPQV----LTSQQ-GR
S----P-------DLPSTQH--W----GVRAL-QSGG----GESLR------PGSVGCRE
SK------------------------------------------GAE--GGS--------
----------------------------------H----TIEKDQGKQGGSKEM----DL
WWKELPKE-------------------------------------EAWDRE------VAF
R-----------PYSAGG----------------------------------GT-GE---
-----DGPLKRKALGKEGVP----------------QERGG-FSVQGE---FSGALGPCQ
RTA-----------------------------------------QTRGASLLQRLHN--G
NASPPRV-----------------------------------------------------
-------------PSPPPA-----------------------------------------
--------------PEPPWPCGDRGDR--GD-----------------------------
------------------------------------------------------------
--------K----------QQA---------------VARGRG----F--P---------
--------------------------GRRG------TRG-----G-NLVTGTQRFQEALK
DPFTLCLANVPGQPDLRHIVIDGSNVAMVHGLQHYFSSRGIAIAVQYFWDRGHRDI----
TVFVPQWRFSKDAKVRESHFLQKLYSLSLLSLTPSRVMDGKRISSYD-------DRFM-V
KLAEETNGIIVSNDQFRDLAEESDKWMAIIRER---------------------------
LLPFTFVGNH------FMVPDDPLGRNGPTLDEFLKKPARK-QGSS-KAQNPSRAFAEHG
----------------------------------NQQ-----------------------
--------------QGRE----EEKGSGG--IRKTRETERLRRQLLEVFRGQDHKV---D
FIL---------------QREPYC-RDINQLSEALLGLNF--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
--------------------------------------------------------MPTW
-EAGCA--SPDRFAVCAEA-EDKVRQQQLHVERIFRVGMSILP---------KDCLQNPH
IWLQLEGPKENASRAKEYLKGLCSPELQDEIHYPPKLHCIFLGAQGFF-LDCLTWSTSAH
----------L---VPGAPGSLMISGLAEAFVMAQSRVEGLVERLSWDFQPGPSLGASQC
AGVLGDFSALLQPWGDAHREALLQLPLAVQEELLSLVQEVSRGQGLQT----LSSWE-ER
G----P-------GLLGAQC--Q----EAGTS-LSEG----RESLD------TGSMGRGE
SR------------------------------------------GVR--GES--------
----------------------------------Y----AVEKEEGKQSGPREM----DL
GWKELPGE-------------------------------------EAWKRE------VAF
R-----------PQLVPK----------------------------------GA-KEV--
-----GPL-KGKALGKEGVP----------------QERGG-VCVQGE---PFGAHGPCQ
RAA-----------------------------------------QPRGASLLQRLHN--G
QASPPRV-----------------------------------------------------
-------------PSPPPA-----------------------------------------
--------------PEPPWHCGDRGD----------------------------------
------------------------------------------------------------
--------K----------QQS---------------MARGRG----S--P---------
--------------------------WKRG------TRG-----G-NLVTGTQRFQEALQ
DPFTLCLANVPGQPDLRHIVIDGSNVAMVHGLQHYFSSRGIAIAVQYFWDRGHRDI----
TVFVPQWRFSKDAKVRESHFLQKLYSLSLLSLTPSRVMDGKRISSYD-------DRFM-V
KLAEETDGIIVSNDQFRDLAEESEKWMAIIRER---------------------------
LLPFTFVGNL------FMVPDDPLGRNGPTLDEFLKKPART-QESS-KAHSPSRGFIEHG
----------------------------------NQQ-----------------------
---------------Q--G-REEEKGSGG--IRKNRETERLRRQLLEVFWGQDHKV---D
FIL---------------QREPYC-RDINQLSEALLSLNF--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
--------------------------------------------------------MPTW
-GAASPIPIPDRFAVSAEA-EDKVREQQARLERIFSVGMSVLC---------KDCPENPH
IWLQLEGPKENVSRAKEYLKGLCSPELRSEVHYPPRLHCIFLGAHGFF-LDCLTWSTSAY
----------L---VPLVSGSLMISGLTEAFVMAQSRVEELAQRLSWDLEPQPGPGTCKS
AGVLRDFSALLLSREDAYREALLQLPLAVQEELLSLVQEVSRGKGSQM----LASWE-GR
N----A-------GLLSAQC--Q----GVKG-----V----RESLN------TGNVGWGE
SR------------------------------------------SAR--GES--------
----------------------------------H----TMKKEGGKH-DPRKM----NS
EWKELSGQ-------------------------------------SQT------------
-----------------------------------------------------A-ED---
-----AEPLKGKALGKEEVP----------------PERG--ASVQGE---PPGAHVLYQ
RAS-----------------------------------------QPRGASLLQRLHN--G
KASPPRV-----------------------------------------------------
-------------PSPPPA-----------------------------------------
--------------PEPRWPCGDRGDR--GD-----------------------------
------------------------------------------------------------
--------K----------QQA---------------MARGRG----S--P---------
--------------------------WKRG------TRG-----G-NLVTGTQRFQEALQ
DPFNLCLANVPGQPDLRHIVIDGSNVAMVHGLQHYFSSRGIAIAVQYFWDRGHRDI----
TVFVPQWRFSKDSKVRESHFLQKLYSLSLLSLTPSRVMDGKRISSYD-------DRFM-V
KLAEETDGIIVSNDQFRDLAEESDKWMAIIRER---------------------------
LLPFTFVGNL------FMVPDDPLGRNGPTLDQFLKKPR-K-QRSS-KAHHPSKGVTEHG
----------------------------------NQQ-----------------------
--------------GSEE-------ESGG--IRKTRETERLRRQLLEVFWGQDHKV---D
FIL---------------QREPYC-RDINQLSEALLSLNF--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
--------------------------------------------------------MPTW
-GAGSP--TPDRFTVSAEA-EDKVRAQQTRLERIFSVGVSVLP---------KDCPENPH
IWLQLEGSKENVSRAKEYLKGLCSPELQSEIHYPPRLHCIFLGAQGFF-LDCLAWSTSAH
----------L---VPGAPGSLMISGLTEAFVMAQSRVEDLVAQLSWDFRPGSYSMTSQS
AGVLRDFSSLLQPWEDAHTEALLQLPLAVQEKLLSLVQEASRGHGPLA----PSSWG-QR
S----P-------GLLGALH--Q----EARPP-LSEG----GESLD------AGSGGQGE
LR------------------------------------------GAS--GVS--------
----------------------------------H----MVEKNRGRQDGPREV----DQ
EWKELLGE-------------------------------------EVWEKE------VTF
R-----------SQPAGG----------------------------------GT-GE---
-----MGCLKGIALGREGVS----------------QERGG-SSVQGE---SPGAQGPSQ
RAS-----------------------------------------QSRGASLLQRLHN--G
EASPLRV-----------------------------------------------------
-------------PSPPPA-----------------------------------------
--------------PEPPWPCGERGD------LGDR------------------------
------------------------------------------------------------
------GDK----------QQ-----------------ARGRG----S--P---------
--------------------------WKRG------TRG-----G-NLVTGTQRFQEALQ
DPFTLCLANVPGQPDLRHIVIDGSNVAMVHGLQHYFSSRGIAIAVQYFWDRGHRDI----
TVFVPQWRFSKDGKVREIHFLQKLYSLSLLSLTPSRVMDGKRISSYD-------DRFM-L
KLAEETSGIIVSNDQFRDLAEESDQWMAIIRER---------------------------
LLPFTFVGNL------FMVPDDPLGRNGPTLDEFLKKPARK-QVSS-KAQHPSRGFSGHG
----------------------------------NQQ-----------------------
--------------QGRE----EEKGSNG--IRKTRETERLRRQLLEVFGGQDHKV---D
FIL---------------QREPYC-RDINQLSEALLSLNF--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
--------------------------------------------------------MLL-
--SGGDPPAQEWFMVQTKS-KSRVQRQRLQVQRIFRVKLNAFQ----------SRPDTPY
FWLQLEGPRENMGKAKEYLKGLCNPELWKEVRYPPILHCAFLGAQGLF-LDCLCWSTLAY
----------L---VPGPPGSLMVGGLTESFIMTQNWLEELVGRLRWGPAPLLTPRGIWE
AEVTRAFGALVWIRGDQHAGDLLQLPPAVQELLLSLVRDAAGKEDI-IEWLSRFGISDSH
---SDP-------EVLI-------------------------------------------
-CPPQQQKAAPALVSVGESPG---PFVDMGTLQ-----NRVPEN--SKRLSSLGATGSLI
---------PAQSTSQ----------EAANQLVRVGSNSQ---GG-MDSAQEEGP---VQ
ATSSQDSTNHTQA--------LLKQKQVQRIEDK--LLFQP--AVSALGVCPSWKAWTPG
PA--------FGPLWPGA------IAATFWRIN---ELHS----LHLAWLLSQACFNFPF
WQ-RPLGPIQLKLPGQNPLPLNLEWKQKELAPLPSAESPAGRPDGGLG---GEAALQNCP
RPEIPP-KVTSLLVVPGSSDVKDKVSSDLPQIGPPLTSTSQVQAGGESGDQGN-IQLDCK
GLEEGPAPVLPTG------------QGKPMAQGGLTDQSVPGAQTVPETLKVPMAAAVPK
AENPPRTQVPPAAPKVPTSQMMPA-VHTESAAPKVPS-----------------------
-------------APTKP------AAQLMAT-AQKTVVNQPVL----AAQVEPTTPKTPQ
AQKMPV---AKTSPAGPKTPKAQAGPAATVSKAPAASKA------------PAAPKVPVT
PKVSRAPKT--------PAAQKVPMDAGPTLDVAKLLSEVQPTSRASASLPKGQGQA-GR
QGPQPSGTLALSSKHQFQMEGLLGA-WEGAPRQPPRHLQ-----ANNTVTSFQRYHEALN
TPFELNLSGEPGNQGLRRVVIDGSSVAMVHGLQHFFSCRGIAMAVQFFWNRGHREV----
TVFVPTWQLKKNRRVRESHFLTKLHSLKMLSITPSQLENGKKITTYD-------YRFM-V
KLAEETDGIIVTNEQIHILMNNS-KKLM--VKDRL-------------------------
-LPFTFAGNL------FMVPDDPLGRDGPTLDEFLKKPNRLDTDIGNFLKV----WKTLP
PSSASVTELSDD-ADSGPLESPPNMEEVREEKEERQDE---E-----------Q------
--RQGQGT--------QKAA-EEDDLDSSLASVFRVECPSLSEEILRCLSLHDPPDGALD
IDLLPGAASPYLGIPWD--GKAPCQQVLAHLAQLTIPSNFTALSFFMGFMDSHRDAIPDY
EALVGPLHRLLKQKPDWQWDQEHEEAFLALKRALVSALCLTAPNSQLPFRLEVTVSHVAL
TAILHQEHSGRKHPIAYTSKPLLPDEDSQGPQSGGDSPYAVAWALKHFSRCIGDTPVVLD
LSYASRTTVDPEVREGRRVSKAWLIRWSLLVQDKGKRALELALLQGLLGENRLLTPA-AS
MPRFFQVLPPFSDLSTFVCIHMSGYCFYREDEWCAGFGLYVLSPTSPPVSLSFSCSPYTP
TYAHLAAVACGLERFGQSPLPVVFLTHCNWIFSLLWELLPLWRARGF-LSSDGAPLPHPS
LLSYIISLTSGLLSLPFIYRTSYRGSLFAVTVDTLAKQGAQGGGQWWSLPKDVPAP-IVT
PHAMGKRPNLLALQLSDSTLADIIARLQAGQKLSGSSPFSSAFNSLSLDKESGLLMFKGD
KKPRVWVVPTQLRRDLIFSVHDIPLGAHQRPEETYKKLRLLGWWPGMQEHVRDYCRSCLF
CIPRNLIGSELKVIESPW---P--LRS--TAPWSNLQIEVVGPVTISEEGHKHVLIVADP
NTRWVEAFPLKPYTHTAVAQVLLQHVFARWGVPVRLEAAQGPQFARHVLVSCGLALGAQV
ASLSRDLQFPCLTSSGAYWEFKRALKEFIFLHGKKWAASLPLLHLAFRASSTDATPFKVL
TGGESRLTEPLWWEMSSANIEGLKMDVFLLQLVGELLELHWRVADKASEK---AENRRFK
RESQEKEWNVGDQVLLLSLPRNGSSAKWVGPFYIGDRLSLSLYRIWGFPTPEKLGCIYPS
SLMKAFAKSGTPLSFKVLEQ----

------------------------------------------------------------
--------------------------------------------------------MLL-
--SGAIPGAGMGFMVTDKIEASGCMRQRLQVPAHLQVKLERFQ----------SRPRTPY
FWHSCEGPREH---GQEYLKGLCSPELWKEVRYPPILHCAFLGAQGLF-LDCLCWSTLAY
----------L---VPGPPGSLMVGGLTESFIMTQNWLEELVGRLRWGPAPLLTPRGIWE
AEVTRAFGALVWIRGDQHAGDLLQLPPAVQELLLSLVRDAAGKEDI-IEWLSRFGISDSH
---SDP-------EVLI-------------------------------------------
-CPPQQQKEALAMVSVGESPG---PFLDMGTLQ-----NRGPEN--SKRLSSLGATGSLI
---------PAQSTPQ----------ETANQLVRVVSNNQ---GG-TDSAREEGP---VQ
ATSSQDCTNYTQD--------LLQQRQVQRVEDK--LLFQP--PVSALGVCPPWKAWTPG
TA--------FGPLWPGA------IAATFWRIN---ELHS----LHLAWLLSQACFNFPF
WQ-RPLGPIQLKLPGQNPLPLNLEWKQKELAPLPSAESPAGRPDGGLG---GEAVLQNCP
RSETPP-KVMSLLVVPGSSDVKDKVSSDLPQIGPPLTSTPQLQAGGEPGDQGS-MQSDCK
GLEEGPGAVLPAG------------KGKPMAQGGLTDHSVPGTQTVPETLKVPMAAAVLK
AENPPRTQVPPAAPKVPTSQMMLA-VHTEPAAPKVPL-----------------------
-------------APTKP------AAQLMAT-AQKTVVNQPVL----AAQVEPTTPKTPQ
AQKMPV---AKTSPAGPKTPKAQTGPAATASKAPAAPKTTAAPKT------PAAPKVPVA
PKVSKAPKT--------LAAQKVPTDAGPTLDVAKLLSEVQPTSRSSASLPKGQGQA-GR
QGPQPSSTLAVSSKHQFQMEGLLGA-WEGAPRQPPRHLQ-----ANSTVTSFQRYHEALN
TPFELNLSGEPGNQGLRRVVIDGSSVAMVHGLQHFFSCRGIAMAVQFFWNRGHREV----
TVFVPTWQLKKNRRVRESHFLTKLHSLKMLSITPSQLENGKKITTYD-------YRFM-V
KLAEETDGIIVTNEQIHILMNNS-KKLMV-K-DR--------------------------
LLPFTFAGNL------FMVPDDPLGRDGPTLDEFLKKPNRLDTDIGNFLKV----WKTLP
PSSASVTELSDD-TDSGPLESLPNVEEVREEEEERQDE---E-----------Q------
--RQGQGT--------QKVA-EEDDLDSSLASVFRVECPSLSEEILRCLSLHDPPDGALD
IDLLPGVASPYLGIPWD--GKAPCQQVLAHLAQLTIPSNFTALSFFVGFMDSHRDAIPDY
EALVGPLHSLLKQKPDWQWHQEHEEAFLALKRALVSALCLTAPNSQLPFRLEVTVSHVAL
TAILHQEHSGRKHPIAYTSKPLLPDEESQGPQSGGDSPYAVAWALKHFSRCIGDTPVVLD
LSYASRTTVDPEVRDSRGVSKAWLIRWSLLVQDKGKRALELSLLQGLLGENRLLTPA-AS
MPRFFQVLPPFSDLSTFVCIHMSGYCFYREDEWCAGFGLYVLSPTSPPVSLSFSCSPYTP
TYAHLAAVACGLERFGQSPLPVVFLTHCNWIFSLLWELLPLWRARGF-LSSDGAPLPHPS
LLSYIISLTSGLSSLPFIYRTSYRGSLFAVTVDTLAKQGAQGGGQWWSLPKDVPVP-VVT
PHPMGKRPNLLALQLSDSTLADIIARLQAGQKLSGSSPFSSAFNSLSLDKESGLLMFKGD
KKPKVWVVPTQLRRDLIFSVHDIPLGAHQRPEETYKKLRLLGWWPGMQEHVRDYCRSCLF
CIPRNLIGSELKVIESPW---P--LRS--TAPWSNLQIEVVGPVTISEEGHKHVLIVADA
NTRWVEAFPLKPYTHTAVAQVLLQHVFARWGVPVRLEAAQGPQFARHVLVSCGLALGAQV
ASLSRDLQFPCLTSSGAYWEFKRALKEFIFLHGKRWAASLPLLHLAFRASSTDATPFKVL
TGGETRLTEPLWWEMSSANIEGLKMDVFLLQLVGELLELHWRVADKASEK---AENRRFK
RESQEKEWNVGDQVLLLSLPRNGSSAKWVGPFYIGDRLSLSLYRIWGFPTPEKLGCIYPS
SLMKTFAKSGTPLSFKVLEQ----

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------EVRYPAALHCAFLGAQGLF-LDCLCWSTLAY
----------L---VPGPPGSLMVGGLTESFIMTQNWLEELVGRLRWGPAPLLTPRGIWE
AEVTRAFGALVWIRGDQYAGDLLQLPPAVQELLLSLVRDAAGKEDI-IEWLSRIGTSDSR
---SDP-------EVLI-------------------------------------------
-CPPHQQKEGPAMVSMGDGPG---PLLEMGTLQ-----NGSPEN--SKRLTSLGATRSLV
SGT------PSQNAQQ----------ETANQLVRVSSNNH---GG-TDSAREEGP---LQ
ATSSQDSANHTQA--------LSQQRQVQRVEDK--LPFQP--PVSALGVCPPWKAWAPG
PA--------FGPLWPGA------IAATFWRIN---ELHS----LHLAWLLSQACLSFPF
WQ-RPLGPIQFKLPGQNALPLNLEWKQKELVPLPSVESPDCRPDGGPG---GEAALQNCP
RPETPK-KVMSLLVVSGGSGVKDKVSPGLPQIGPPLTSMPQLQAGSELGDQRS-VQLDCK
GPEEGPCPVPPTG------HEVPPAQGGPVAQGGPTVQSVPDAQTVPETRKVPVAAAVPT
AQPPPTNQVLPAAPEVPTAQMMPA-VQAEPATPKVPL-----------------------
-------------APTKP------AAQVVPT-AQKAAVGQPAS----AARMVPATPKTPT
AQKMPA---AKASPAGPKTPKAHPGPAAKTGT---SPKA------PAAPKAPAAPKASAA
SKAPRVPQT--------PAAQKVPTDLGPNLDAAKLLSERQPSSRGSTSFPKGQGDV-GR
QGSQSSSTLAPRSKHQPQGEGLLGA-WEGAPRQPPRHPQ-----ANSTVTSFQRYHEALN
TPFELNLSGEPGDQGLRRVVIDGSSVAMVHGLQHFFSCRGIAMAVQYFWNRGHREV----
TVFVPTWQLKKNRRVRESHFLTKLHSLKMLSITPSQLENGKKIATYD-------YRFM-V
KLAEETDGIIVTNEQLHILMNNS-KKLMV-KDR---------------------------
LLPFTFAGNL------FMVPDDPLGRDGPTLDEFLKKPNRLDTDIGNFLKV----WKTLP
PSSASISELSDD-ADPAPLESPQTVEEVREEEEEGQDE---E-----------Q------
--REEQEM--------HEPVEEKDDLDSSLASVFKAECPSLSEEILQCLSLHDPSDGALD
IDLLPAVASPHLGIPWD--GKPPCQQVLAHLAQLTIPSNFTALSFFVGFMDSHRDVIPDY
EALVGPLHSLLKQKPDWQWDREHEKAFLALKRALVSALCLAAPNPQLPFRLEVMVSHVAL
TAIVYQEHSGRKHPIAYTSKPLLPDEDSEGPQSGGDSPYAVAWALKHFSRCIGDTPVVLD
LSYASRTTVDPEAREDRRVSKAWLIRWSLLVQDKGKRALELTLLQGLLGGNRLLTPA-SS
MPRFFQVLPPFSDLSTFVCIHMSGYCFYREDEWCAGLSI-VLSPTSAPVSLSFSCSPYTP
TYAHLAAVACGLERFGQSHLPVVFLTHCNWIFSLLWELLPLWKARGF-LSSDGAPLPHPS
LLSYIISLTSGLSSLPFIYRTSYRGSLFAVTVDTLAKQGAQGGGQWWNLPKDVPAP-VVS
PHTMGKRPDLLALQLSDSTLADIIAKLQAGQKLSSSSPFSSAFNSLSLDKESGLLMFKGD
KKPRVWVVPRQLRRDLIFSVHDLPMGAHQRPEETYKKLRLLGWWPGMQEHVRDYCRSCLF
CIPRNLIGSELKVIESLW---P--LRS--TAPWSNLQIEVVGPVTISEEGHKHVLIVADP
NTRWVEAFPLKPYTHTAVAQLLLQHVFARWGVPVRLEAAQGPQFARHVLVSCGLALGAQV
ASLSRDLQFPCLTSSGAYWEFKRALKEFIFLHGKKWAASLPLLHLAFRASSSQATPVQIL
TGAEVRLTEPLWWEMSSANIEGLKMDVFLLQLMRELLELHCRVADKASEK---AENRRFR
RESQEKEWNVGDQVLLLSLPRNGSSAKWVGPFYIGDRLSLSLYRVWGFPTPEKLGCIYPS
SLMKAFAKSGTPLSFKVLEQ----

------------------------------------------------------------
--------------------------------------------------------MLL-
--SGGDPPAQEWFMVQTKS-KPRVQRQRQQVQRIFRVKLNAFQ----------SRPDTPY
FWLQLEGPRENMGKAKEYLKGLCNPELWKEVRYPAALHCAFLGAQGLF-LDCLCWSTLAY
----------L---VPGPPGSLMVGGLTESFIMTQNWLEELVGRLRWGPAPLLTPRGIWE
AEVTRAFGALVWIRGDQYAGDLLQLPPAVQELLLSLVRDAAGKEDI-IQWLSRIGTSDSR
---SDP-------ELLI-------------------------------------------
-CPTHQQKEGPTMVAVGDGPG---PFVEMG----------SPEN--SKRLTSLGATGAVI
SGT------PGPNTQQ----------ETANQLVRVTSNNQ---GG-VDCSREEGS---VQ
ASSSQDPVDHTQA--------SSQQRQVRRGEDK--LPLQP--PVSALSVCSPWKAWTPG
PT--------FAPMWPGA------IAATFWRIN---ELHS----LHLAWLLSQACFSFPF
WQ-RPLGPIQFKLPGQNPLPLNLGWKQKELVPLPSVESPDCTPDGGPG---GEAALQNCP
RPETPK-KVVSLLVVSGGSGVKDKSIPGLPQIGPPLTSTPQLQASSELGDQGS-VQWDCK
GPEEGPEAAPPTGQGVPAAQGGLA------------APSGPDSKTVPETLKVPVAAAMPT
AQAPPTSPVLPAAPKVPETQMVAA-AHEERAASEVPS-----------------------
-------------VPTKPA------AQVVPT-AQKA-----------------AAPHTPA
AQKRQA---AKASPTGPQTPRAQPGPAPKTG--------------------PTAPKAPAA
PQTSRTPKT--------PAAQKAPAGPGSTLDAGKLVSEGQPPSRGSASFLKGQGQP-GS
QGPQCSGPLAPSTKRQPQVEGLLGA-GEGTPRQPTRHPQ-----ASNTVTSFQRYHEALN
TPFELDLSEEPGNPELRRVVIDGSSVAMVHGLQHFFSCRGIAMAVQYFWNRGHREV----
TVFIPTWQLKKNRRVRESHFLTKLHSLKMLSITPSQLENGKKITTYD-------YRFM-V
KLAEETDGVIVTNEQLHVLMNNS-KKLMV-KDR---------------------------
LLPFTFAGNL------FMVPDDPLGRDGPTLDEFLKKPNRLDTDIGNFLKV----WKTLP
PSSASISELRDD-TDPGPPESLQNVEEVREEQE-EER---------QDE---EQ------
--REEQEMQ---KP----AEEEEEDLDSSLMSVFRAECPSLSEEILRCLSLHDPQDEALD
IDLQPAVASPSLGIPWD--GKAPCQQVLAQLAQLTIPSNFTALSFFMGFTDSHRDVIPDY
EALVAPLHSLLKQKPDWRWELDHEKAFLALKRALVSALCLSVPNPQLPFHLEVTVSQVAL
TAVVYQEHSGRKHPVAYTSKPLLPDEDSEGPQSGGDSPYAVAWALKHFSRYIGDTPVVLD
LFYASRTSVDPEAWDGRRVAKAWLIRWALLVQDKGKRALELTLLQGLLGKNRLLTPT-AC
MPRLFQVLPPFSDLSTFVCIHMSGYCFYREDEWCAGFGLYVLSPTSAPVSLSFSCSPYTP
TYAHLAAVACGLERFGRSHMPIVFLTHCNWIFSLLWELLPLWRARGF-LSSDGTPLPHPS
LLSYIIDLTSGLSSLPFIYRTSYRGSLFAVTVDTLAKEGAQGGDQCWNLPNDVPAP-IVT
PRTVCKRPDLLALQRSDGTLADIMAKLQAGQKVSNSSPFSSAFSSLSLDKESGLLMFKGD
KRPRVWVVPRQLRRDLIFAVHDGPMGAHQRPEETYRKLRLLGWWPGMQEHVRHYCRSCLF
CIPRNLLGSEVKVIESLW---P--LRS--TAPWSNLQIEVVGPVTVSEEGHKHVLIVADP
NTRWVEAFPLKPYTHTAVAQLLLQHVFARWGIPVRLEAAQGPQFARHVLVSCGLALGVHV
ASPSRDLQFPCLTSSGAYWEFKRALKEFIFLHGKKWAASLPLLHLAFRASSSQASPFRIL
TGAEERLTEPLWWEMSSANIEGLKMDLFLLQLTRELLELHWRLAEKTSEK---AENRRFK
RERQEKEWNVGDQVLVLSLPRNGSSAKWVGPFYIGDRLSPSLYRVWGFPTPEKLGCIYPS
SLMKPFAKSVTPLSFKVLEQ----

------------------------------------------------------------
--------------------------------------------------------MLL-
--SGGRPPAQEWFMVQSKS-KPRVHRQRLQVQRIFRVKVNAFQ----------SRPDNPY
FWLQLEGPRENTGKAKEYLKGLCSPELWKEVRYPPVLHCAFLGAQGLF-LDCLCWSTLAY
----------L---VPGPPGSLMVGGLTESFTMTQNWLEELVARLRWGPAPMTTPRGIWE
TEVTRAFGALVWIRGDQYARDLLQLPPAVQELLLSLVRDAAGKEDI-VDWLGHFGISSVC
---SN--------PEVL-----I-------------------------------------
-CPSQQQKEGSSLVTVGESPG---PFLEIGTWN------QASEN--SKGSTGLGAAGSLM
---------PAQSTQR----------ERACQLV-IRSNKQ---GD-ANSAREEGAI--VQ
AISSQDSANHTQA--------LLQQRQVQRMENR--MSLQS--PVSALSV------WAPG
PA--------FGPLWPGT------IAATFWKIN---ELQS----LHLAWLLSQACFNFPF
WQ-RPGVPIQLKLPGQTPLPLNLEWKPKELAPLPSAENQACRPDGEPG---RETALEHSP
KPEMPT-EVTSLSVVPGDCVIKEMVSSGPPQVGPSLTSIPQ-------ARVDS-ALSDGK
GLEKLSSSVLPTEQ------RGPTAQEKPVAQAEMTDQSVPKAPTLSET----LEMPTA-
--IAASKEGLPA----------APKVSAVCTEP---A-----------------------
-------------APKVPPAPS-----------------------------KPAAPTGN-
-----------ATKAGSA-----------------------------TPKTPSTTKAPAT
SKASRA-------------STTSAAQGPMAADVAKPLSEVQASKS-RAAGPKGQGKA-GR
QGLQASSTLASRNKHPFLREGLLGA-WEGAQRPSSHHPQ-----ANNTVTSFQRYHEALN
TPFELNLSGEPGNPGLRRVVIDGSSVAMVHGLQHFFSCRGIAMAVQYFWNRGHREV----
TVFVPTWQLKKNRRVRESHFLTQLHSLKMLSITPSQLENGKKITTYD-------YRFM-V
KLAEETDGIIVTNEQIHILMNNS-KKLMV-RDR---------------------------
LLPFTFAGNL------FMVPDDPLGRDGPTLDEFLKKPNRLDMDIGNFLKV----WKTLP
PSSASISELSDD-ADPEPLVAPQNVK------------ELMQ------------------
-------------GPGAPEPDEQDDHDSSLVSVFGAECPPFSEEILWCLSLHDPSEGALD
IDLLPVVSSPYVDAPWD--GKAPCQQVLAQLAQLTIPSNFTALSFFMGFMDSHRDVIPDY
EVLMGPLHSLLKQKPDWQWNQEHEKAFLALKRALVSALCLSTPNSHLPFYLEVTVSQVSL
TAILQQEHSGRKHPIAYTSKPLLPDEDSEGPQSGGDSPYAVAWALKHFSRYIGDNPVVLR
LSYASRTTVDNETWESHRVSKAWLIRWSLLVQDKGKRDLELTLLRGLLGENQLLTPA-SS
MPRVFQLLPPSTDLSTFICIHISGYCFYRDDELCAGFGLYILSPTSPPVSLAFSCSPYTP
TYAHLAAVACGLERFGQSRLPVVFLTHCNWIFTVLWELLPLWKARGF-LSSDGAALPHPS
LLSYIMSLTSGFSSLPFIYRTSYRGSLFAVTVDNLAKQGAQGGGQWWDLPKDVPVP-MVT
PHTKGRKPDLLALQLSDSTLADIIAKLQAGQRLSGPSPFSSAFNSLSLDKDSGLLMFKGE
KHPRVWVVPRQLRRDLIFSVHDIPLGGHQRPEETYKKLRLLGWWPGMQEHVKDYCRSCLF
CIPQNLTEGEFKVIESPWP-----LRS--TAPWSSLQIEVVGPVTASEEGHKYVLIVADA
NTRWVEAFPLKPYTHMAVAQVLLQHVFARWGVPMRLEAAQGPQFARHVLVSCGLALGAQV
TTLSRALQFPCLMSSEAYWEFKRALKEFIFLYGKKWAASLPLLHLAFRASTTEATPYQVL
TGGEMRLMEPLWWEMSTANIEGLKMDAFSLQLMRELLDVHWRVAEKASEK---ADNRRLK
REMQEKEWTVGDQVLLLSLPRNGSSAKWVGPFYIGDRLSLSLYRVWGFPTPEKLGCVYPS
SLMKAFANGSTPLSLSVSLSDLEL

------------------------------------------------------------
--------------------------------------------------------MPTW
-GAGAQ--SPDRFAVSAAA-EDRVREQQLCVERIFGVGMSVLP---------KDCPENPH
IWLQLEGPKENVSRAKEYLKGLCSPELQEEIHYPPQLHCIFLGARGLF-LDCLAWSTCAH
----------L---VPRAPGLLVVGGLTEAFVMAQSRVEELVERLSCDFRPGLSP----G
AGVTSNFSALLQSWPDDHRAALLQLPLAVQEELLSLVQEVSRGRGLQV----PPSWE-GN
P----R-------ELRAP---------------PGEA----RGSLD------MGSMGQGD
CR------------------------------------------MAR--EEG--------
----------------------------------H----AMLKEVGRLGGPREM----EL
RWKELPGG-------------------------------------EAWERE------VAF
R-----------TQTAGG----------------------------------RT-GE---
-----EGPLKGKAPGKEGVP----------------QERGG-LSVQGE---PPGAHGPCQ
RAA------------------------------------------QRGASLLQRLHN--G
SASPPRV-----------------------------------------------------
-------------PSPPPA-----------------------------------------
--------------PEPRWHCGDRGDR--GD-RGDR------------------------
------------------------------------------------------------
------ADK----------PQA---------------GARGRG----S--P---------
--------------------------WKRG------ARG-----G-NLVTGTQRFQEALQ
DPFNLCLANVPGQPGLRHIVIDGSNVAMVHGLQHHFSSRGIAIAVQYFWDRGHRDI----
TVFVPQWRFSRDSKVRESHFLQKLYSLSLLSLTPSRVMDGKRISSYD-------DRFM-V
KLAEETDGIIVSNDQFRDLAEESDKWMAIIRER---------------------------
LLPFTFVGNL------FMVPDDPLGRNGPTLDEFLKKPART-QGSS-KAQHPPKGVAGHN
----------------------------------NKQ-----------------------
--------------QGKE----EEQGSSG--IRKTRETERLRRQLLEVFLGQDHKV---D
FIL---------------QREPYC-RDINQLSEALLSLNF--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
--------------------------------------------------------MPTW
-GAGSL--SPDRFAVSAEA-EDKVREQLPRVERIFRVGMSVLP---------KDCPENPH
IWLQLEGPKENASRAKEYLKGLCSPELQNEIHYPPKLHCIFLGAQGFF-LDCLTWSTSAH
----------L---VPGVPGSLMVSGLTEAFVMVQSRVEELVERLSWDFRLGPSPGASQC
AGVLREFSALLQARGDAHTEALLQLPQAIQEELLSLVQEASRGQGPQA----FLSWG-WG
G----P-------GPLGAQQ--Q----GVRTP-LGDS----GVSLD------TGPTGWQE
ST------------------------------------------GE-----R--------
----------------------------------H----AVEKEGTKQSGAREM----DL
GWKEWPGE-------------------------------------EAWERQ------VAF
R-----------PQSGG----------------------------------GEA-GQA--
-----GPP-KGKALGKEGVP----------------QERGR-LGVQGQ---PPGTQGPYQ
RAS-----------------------------------------QLRGASLLQRLHN--G
EASPPRV-----------------------------------------------------
-------------PSPPPA-----------------------------------------
--------------PEPPWHCGDRGDRGE------R------------------------
------------------------------------------------------------
------ADK----------QLV---------------VARGRG----S--P---------
--------------------------WKRG------TRG-----G-NLVTGTQRFQEALQ
DPFTLCLANVPGKPDLRHIVIDGSNVAMVHGLQHYFSSRGIAIAVQYFWDRGHRDI----
TVFVPQWRFSKDSKVREGHFLHKLYSLSLLSLTPSRVLDGKRISSYD-------DRFM-V
KLAEETDGIIVSNDQFRDLAEESEKWMAIIRER---------------------------
LLPFTFVGNL------FMVPDDPLGRNGPTLDEFLKKPVRA-PGSS-KPQHSARGVTEHS
----------------------------------NQ------------------------
--------------QP--GRKEEEKGNGG--IRKTRETERLRRQLLEVFWGQDHKV---D
FIL---------------QREPYC-RDINQLSEALLSLNF--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
--------------------------------------------------------MLL-
--SGGDPPAQEWFMVQTKS-KSRVQRQRLQVQRIFRVKLNAFQ----------SRPDTPY
FWLQLEGPRENMGKAKEYLKGLCNPELWKEVRYPPILHCAFLGAQGLF-LDCLCWSTLAY
----------L---VPGPPGSLMVGGLTESFIMTQNWLEELVGRLRWGPAPLLTPRGIWE
AEVTRAFGALVWIRGDQHAGDLLQLPPAVQELLLSLVRDAAGKEDI-IEWLSRFGISDSH
---SDP-------EVLI-------------------------------------------
-CPPQQQKAAPALVSVGESPG---PFVDMGTLQ-----NRVPEN--SKRLSSLGATGSLI
---------PAQSTSQ----------EAANQLVRVGSNSQ---GG-MDSAQEEGP---VQ
ATSSQDSTNHTQA--------LLKQKQVQRIEDK--LLFQP--PVSALGVCPSWKAWTPG
PA--------FGPLWPGA------IAATFWRIN---ELHS----LHLAWLLSQACFNFPF
WQ-RPLGPIQLKLPGQNPLPLNLEWKQKELAPLPSAESPAGRPDGGLG---GEAALQNCP
RPEIPP-KVTSLLVVPGSSDVKDKVSSDLPQIGPPLTSTSQVQAGGESGDQGN-IQLDCK
GLEEGPAPVLPTG------------QGKPMAQGGLTDQSVPGAQTVPETLKVPMAAAVPK
AENPPRTQVPPAAPKVPTSQMMPA-VHTESAAPKVPS-----------------------
-------------APTKP------AAQLMAT-AQKTVVNQPVL----AAQVEPTTPKTPQ
AQKMPV---AKTSPAGPKTPKAQAGPAATVSKAPAASKA------------PAAPKVPVT
PKVSRAPKT--------PAAQKVPMDAGPTLDVAKLLSEVQPTSRASASLPKGQGQA-GR
QGPQPSGTLALSSKHQFQMEGLLGA-WEGAPRQPPRHLQ-----ANNTVTSFQRYHEALN
TPFELNLSGEPGNQGLRRVVIDGSSVAMVHGLQHFFSCRGIAMAVQFFWNRGHREV----
TVFVPTWQLKKNRRVRESHFLTKLHSLKMLSITPSQLENGKKITTYD-------YRFM-V
KLAEETDGIIVTNEQIHILMNNS-KKLM--VKDRL-------------------------
-LPFTFAGNL------FMVPDDPLGRDGPTLDEFLKKPNRLDTDIGNFLKV----WKTLP
PSSASVTELSDD-ADSGPLESPPNMEEVREEKEERQDE---E-----------Q------
--RQGQGT--------QKAA-EEDDLDSSLASVFRVECPSLSEEILRCLSLHDPPDGALD
IDLLPGAASPYLGIPWD--GKAPCQQVLAHLAQLTIPSNFTALSFFMGFMDSHRDAIPDY
EALVGPLHRLLKQKPDWQWDQEHEEAFLALKRALVSALCLTAPNSQLPFRLEVTVSHVAL
TAILHQEHSGRKHPIAYTSKPLLPDEESQGP-SGGDSPYAVAWALKHFSRCIGDTPVVLD
LSYASRTTVDPEVREGRRVSKAWLIRWSLLVQDKGKRALELALLQGLLGENRLLTPA-AS
MPRFFQVLPPFSDLSTFVCIHMSGYCFYREDEWCAGFGLYVLSPTSPPVSLSFSCSPYTP
TYAHLAAVACGLERFGQSPLPVVFLTHCNWIFSLLWELLPLWRARGF-LSSDGAPLPHPS
LLSYIISLTSGLLSLPFIYRTSYRGSLFAVTVDTLAKQGAQGGGQWWSLPKDVPAP-IVT
PHAMGKRPNLLALQLSDSTLADIIARLQAGQKLSGSSPFSSAFNSLSLDKESGLLMFKGD
KKPRVWVVPTQLRRDLIFSVHDIPLGAHQRPEETYKKLRLLGWWPGMQEHVRDYCRSCLF
CIPRNLIGSELKVIESPW---P--LRS--TAPWSNLQIEVVGPVTISEEGHKHVLIVADP
NTRWVEAFPLKPYTHTAVAQVLLQHVFARWGVPVRLEAAQGPQFARHVLVSCGLALGAQV
ASLSRDLQFPCLTSSGAYWEFKRALKEFIFLHGKKWAASLPLLHLAFRASSTDATPFKVL
TGGESRLTEPLWWEMSSANIEGLKMDVFLLQLVGELLELHWRVADKASEK---AENRRFK
RESQEKEWNVGDQVLLLSLPRNGSSAKWVGPFYIGDRLSLSLYRIWGFPTPEKLGCIYPS
SLMKAFAKSGTPLSFKVLEQ----

------------------------------------------------------------
--------------------------------------------------------MLL-
--SRGEPPALEWFMVQTKS-KPRVQRQRLQVQRVFRVKLNAFQ----------SRPDTPY
FWLQLEGPRENTSKAKEYLKGLCSPELWKEVRYPPMLHCAFLGAQGLF-LDCLCWSTLAY
----------L---VPGPPGSLMVGGLTESFTMTQNWLEELVARLRWGPAPLLTPRGIWE
AEVSRAFGALVWIRSDQYAGDLLQLPPAVQELLLSLVRDAAGKEDI-IEWLSHFGISNTR
---SGP-------EVLI-------------------------------------------
-SPPQQQKEDSAVVSMGGSPG---SILEMGTLQ-----IGGPEN--PKRVSSLRATKSLI
---------PVQNTQQ----------KTANQLVRVGDNNQ---GG-TNSVQEEGL---IQ
ATSSQDSVNRMPA--------LLHQKQVHKVEEK--FLFQP--SVSALGMCPSWKGWAPG
PA--------FGPLRPGT------IAAAFWRIN---ELHS----LHLAWLLSQACFSLPF
WQ-RPLGPIQLKLPGQSALPLNLEWKQKELSPLPCAEGPACRPDGELG---GETSLQNCP
RPETPP-KVVSLLVVPGGSGAKDKVSPGLPRIGLPLAST--AQAGDKRGNQGG-MRPDYE
WLEKGPSPAPPTEQEAP------TAQGRPMAQEGLTAQSAPEVRTVPETLKVPMAAAVPK
AENPPITQRQPAAPKVPTSQMMLA-MSTEPAATQVP------------------------
-------------AATKP------AAQVVST-ARKATVDQPAS--ASAAQETSATPKTVM
AQKMPA---ATTSPANPQILQAHAGPVTKMGCA--APKISAAPKESAAPKTSAVPKAPGA
SKASRPPKT--------SAAQKVPPGEGPTLDVARLLSEVQPLSRGDGSLPKGQGEP-GR
QGAQPSSTLALSNQHQFRVEGLLGD-WKGGPRQSPRHPQ-----ANSTVTSFQRYHEALN
TPFELNLSGEPGNQELRRVVIDGSSVAMVHGLQHFFSCRGIAMAVQYFWNRGHREV----
TVFVPTWQLKKNRRVRESHFLTKLHSLKMLSITPSQLENGKKIATYD-------YRFM-V
KLAEETDGIIVTNEQIHTLMNNS-KKLTV-KDR---------------------------
LLPFTFAGNL------FMVPDDPLGRDGPTLDEFLKKPNRLDTDVGNFLKV----WKTLP
PSSASISELNGD-PDPRPLERPQDVEEVREEKEEKQNEECR-------------------
---EGQE---------TPQWAEEDDLDSSLASVFGVECPSLSEEILQCLSLHDPPDGALD
IDLLPGVASPYLGIPWD--GKAPCQQVLAQLAQLTTPSNFTVLSFFVGFMDSHRDVIPDY
EGLMGPLHSLLKQKPDWQWDQEHEKAFLSLKRALVSALCLTAPNSQLPFRLQVTVSQVAL
TAILYQEHSGRKHPIAYTSKPLLPDEDSEGPQSGGDSPYAVAWALKHFSRCIGDAPVVLD
LSYASRTAVAPEAPEGRRVSKAWLIRWSLLVQDRGKRTLELALLQGLLRENRLLTPA-SS
MPRFFQVLPPFSDLSTFVCIHMSGYCFYREDEWCAGFGLYVLSPTSAPVSLSFSCSPHTP
TYAHLAAVACGLERFGQSHLPVVFLTHCNWIFSLLWELLPLWRARGF-LSSDGAPLPHPG
LLSYIISLTSGLPSLPFIYRTSYRGSLFAVTVDNLAKQGAQGGGQWWNLPKDVPVP-VVT
PHATGKRPNLLALQLSDSTLADIIAKLRAGQKLPGSSPFSSAFNSLSLDKESGLLMFKGD
KKPKVWVVPRQLRRDLIFSVHDIPMGAHQRPEETYKKLRVLGWWPGMQEHVKDYCRSCLF
CIPRNLTGSELKVIESPW---P--LRS--TAPWSNLQIEVVGPVTTSEEGHRHVLIVADP
NTRWVEAFPLKPYTHMAVAQVLLQHVFARWGVPMRLEAAQGPQFARHVLVSCGLALGAQV
TCLSRDLQFPCLVSSEAYWEFKRALKEFIFLHGKKWASSLPLLHLAFRASSTVATPFRVL
TGGEGRLTEPLWWEMSSANIEGLKMDVFLLQLIRELLELHWKVAEKGAEK---ADNRRFK
QESQEKEWNVGDQVLLLSLPRNGSSAKWVGPFYIGDRLSFSFYRVWGFPTPEKLGCIYPS
SLMKAFAKSGTPLSFKDLEQ----

------------------------------------------------------------
--------------------------------------------------------MLL-
--SGGDPPAQEWFMVQTKS-KARVQRQRLQVQRIFRVKLNAFQ----------SRPDTPY
FWLQLEGPRENMGKAKEYLKGLCSPELWKEVRYPPILHCAFLGAQGLF-LDCLCWSTLAY
----------L---VPGPPGSLMVGGLTESFVMTQNWLEELVGRLRWGPVPLLTPRGIWE
AEVTRAFGALVWIRGDQYAGDLLKLPPAVQELLLSLVRDAAGKEDI-IEWLGRFSISDTH
---SEP-------EALI-------------------------------------------
-CPPLQQKEGPAMVSVGESPG---PLLEEEPLQ-----NGSPEK--SKRLISLGATASLV
---------PVQSTQQ----------VATSQLVRVGSNDQ---NS-TDSAQEDGP---VQ
ATSSQDSSNHTQL--------LLQQRKVPRVEDK--FPFQP--PVSALGVCPPWKVWTPG
PV--------LGPLWPGT------IAATFCRIN---ELHS----LHLAWLLSQACFNFSF
WQ-RSLGPIQLKLPGQNPLPLNLEWKQKELTPLPSVGSSACEPVRGLG---GEVALQNCP
RPETPS-KVMSLLVVPGASGVEDKGSPGLPQIEPPLTSTPLLQIGGEPGDQGS-MQLVCK
DLKERPSPAPPTGQ------------GKP-----MTTQSVPEAQTVPEMLKVPVATAVSK
AENPRPTQGLPAAPEVPTAQMTPA-AHTEPVAPEVPS-----------------------
-------------APTRPA------AQVVPT-AQKAAVGQPAS----AGQVVPTIPKTPT
AQKMPA---GKTSTASPKTPKAQKGSGAKKRST--------APK------APAAPKAYAI
PKTSKATQT--------PVAQKASTGAGSVLDVAKLLSEVQLSSRGSASLPKGQGEAGGR
QGPQPSSTSALGSKHSFQMEGLLGAPWEGAPRQSPRHPQ-----ANSTVTSFQRYHEALN
TPFELNLSEEPGNQGLRRVVIDGSSVAMVHGLQHFFSCRGIAMAVQFFWNRGHREV----
TVFVPTWQLKKNRRVRESHFLTQLHSLKMLSITPSQLENGKKITTYD-------YRFM-V
KLAEETDGIIVTNEQIHILMNNS-KKLLI-KDR---------------------------
LLPFTFAGNL------FMVPDDPLGRDGPTLDEFLRKPNRLDTDIGNFLKV----WKTLP
PSSASASKLSED-ADPKPVESPPRMEEVREKEERQDEE---------------Q------
--KEGQGMQEMQEMQEMAEMAEEDDLDSSLASVFGVECPSFSEEILQCLSLHDPADTALD
IDLLPGVAAPHLGIPWD--GKAPCQQVLTHLAQLTVPSNFTALSFFVGFMDSHQEVIPDY
EALVGPLHSLLKQKPDWQWDWEHEKAFLALKRALVSALCLTAPNPQLPFLLEVTVSQVAL
TAILQQEHSGQRHPVAYTSKPLLPDEDSEGPQSGGDSPYAVAWALKHFSHCIGDTPVVLD
LAYASRTSVDPEALEGRRVSKAWLIRWSLLVQDKGKRALELTLLQGLLRENQLLMPA-SS
MPRFFQVLPPFSDLSTFVCIHMSGYCFYREDEWCAGFGLYVLSPTSPPVSLSFSCSPYTP
TYAHLAAVACGLERFGQSQLPVVFLTHCNWIFSILWELLPLWRARGF-LSSDGAPLPHPS
LLSYIISLTSGLSSPPFIYRTSYRGSLFAVTVDTLAKQGAQGGGEWWSLPEDVPVP-LVT
PHTLGRRPNLLALQLSDSILADIIAKLQAGQKPPNSSPFSSAFNSLSLDKESGLLMFKGD
KQPMVWVVPRQLRRNLIFSVHDVPLGAHQRPEETYKKLRLLGWWPGMQEHVKQYCRSCLY
CIPRNLIGSELKVIESVW---P--LRS--TAPWSSLQIEVVGPITVSEEGHKHVLIVADP
NTRWVEAFPLKPYTHKAVAQVLLQHVFARWGVPMRLEAAQGPQFARHVLVSCGLALGAQV
TSLSRNLQFPCLTSSDAYWEFKRALKEFIFLHGKKWAASLPLLHLAFRASSADASPFRVV
TGGEVRLAEPLWWEMSSANIEGLKMDIFLLQLVRELLELHWRVADKAEEK---AENRRFK
RESQEKEWNVGDQVLLLSLPRNGSSAKWVGPFYIGDRLSLSLYRVWGFPTPEKLGCVYPS
SLMKAFAKSGTPLSFKVLEQ----

------------------------------------------------------------
--------------------------------------------------------MPTW
-EARPA--SPDRFAVSAEA-ENKVREQQPHVKRIFSVGVSVLP---------KDCPDNPH
IWLQLEGPKENASRAKEYLKGLCSPELQDEIHYPPKLHCIFLGAQGFF-LDCLAWSTSAH
----------L---VPRAPGSLMISGLTEAFVMAQSRVEELTERLNWDFMPGPSSGASQC
TGVLRDFSALLQSPGDAHREALLQLPLAVQEELLSLVQEASSGQGPGA----LASWE-GR
S----S-------GLLGAQC--Q----EERAP-PSDG----RESLD------TGSVGPRD
SR------------------------------------------GAR--GDN--------
----------------------------------Y----AVGKEGGKQGGPREM----DL
GWKELPGE-------------------------------------EAWERE------VAL
R-----------PQSVGG----------------------------------GL-RES--
-----ALL-KGKALGKEEVT----------------QGGGG-LCVHRE---PPGAHGSCH
RAA-----------------------------------------QSRGASLLQRLHN--G
NASPPRV-----------------------------------------------------
-------------PSPPPA-----------------------------------------
--------------PEPPWHCGDRGDWGDRGDGGDR------------------------
------------------------------------------------------------
------GDK----------QQG---------------MARGRG----P--Q---------
--------------------------WKRG------ARG-----G-NLVTGTQRFKEALQ
DPFTLCLANVPGQPDLRHIVIDGSNVAMVHGLQHYFSSRGIAIAVQYFWDRGHRDI----
TVFVPQWRFSKDSKVRESHFLQKLYSLSLLSLTPSRVMDGKRISSYD-------DRFM-V
KLAEETDGIIVSNDQFRDLAEESEKWMAIIRER---------------------------
LLPFTFVGNL------FMVPDDPLGRNGPTLDEFLKKPART-QGSS-KAQHPSRSFAEHG
----------------------------------KQQ-----------------------
---------------H--G-REEEKGSGG--IRKTRETERLRRQLLEVFWGQDHKV---D
FIL---------------QREPYC-RDINQLSEALLSLNF--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
--------------------------------------------------------MLL-
--AGGEPPALEWFMVQTKS-KPRVQRQRLQVQRIFRVKLNAFQ----------SRPDTPY
FWLQLQGPRENTSKAKEYLKGLCSPELWKEVRYPPMLHCAFLGAQGLF-LDCLCWSTLAY
----------L---VPGPPGSLMVGGLTESFTMTQNWLEELVARLRWGPAPLLTPRGIWE
AEVSRAFGALVWIRGDQYARDLLQLPPAVQELLLSLVRDAAGKEDI-IEWLSHVGISSTC
---SSP-------EVLI-------------------------------------------
-SPPQQQKEDSTVVSVGENPG---SFLEMGTLQ-----NGGPEN--PKRVSSLGASRSLI
---------AVQNTQQ----------ETANQMVWVGSINQ---SG-TDSAQEEGL---VQ
ATSSQNSVNRTPA--------LLQQKQIHKVEEK--FLFQP--PVSALSMCPSWKAWAPG
PA--------FGPLWPGT------IAAAFWRIN---ELHS----LHLAWLLSQACFSLPF
WQ-RPLGPIQLKLPGHSALPLNLEWKQKELAPLPSAESPACRPDGELG---GEAALQNCP
RPETPP-KVVSLLVAPGGCDEKDKVSPGLPRKGLPLAST--TQTGDKQENQGS-VQLDCK
WLEKGPSPVPPTELGEP------TAQGKPMAQGVLTVQSESEARTVPETLKVPMAAAVPK
AENSPITQKQPAAPQVPPSQTMQA-VSTETAAPQVPPSQTMLAVSTETAAPQVPTSQTML
EVSTETAAPKVPLAPAKP------AAQVVST-AQKAAVHQPAS--ASAAQVTSTALKTAM
SSKMPA---AKISPANPKTLKAHPGPGTKTGSA--PPKTSAAPKAPAAPKTSASSKAPGA
SKASRVAKT--------PAVQKGPTGEGTTLDVARLLSEVQPLSRGDASLSKGQEEP-RR
QGAQSSSTLALSNKHQFQVEGLLGA-GEGSPRQSPRHPQ-----ANSTVTSFQRYHEALN
TPFELNLSGEPGNQELRRVVIDGSSVAMVHGLQHFFSCRGIAMAVQYFWNRGHREV----
TVFVPTWQLKKNRRVRESHFLTKLHSLKMLSITPSQLENGKKIATYD-------YRFM-V
KLAEETDGIIVTNEQIHTLMNNS-KKLMV-KDR---------------------------
LLPFTFAGNL------FMVPDDPLGRDGPTLDEFLKKPNRLDTDVGNFLKV----WKTLP
PSSASISELNDD-PDPRPLESPQNVEEVREK-EERPNEEWR-------------------
---EGRG---------MPEQAEEDDLDSSLASVFRVECPSLSEEILQCLSLHDPPDGALD
IDLLPGAASPSLGIPWD--GKAPCQQVLAQLAQLTTPNNFTVLSFFVGFMDSHRDVIPDY
EALMGPLHNLLKQKPDWQWGQEHEKAFLSLKRALVSALCLTAPNSQLPFRLQVTVSQVAL
TAILFQEHSGRKHPIAYTSKPLLPDEDSEGPQSGGDSPYAVAWALKHFSRCIGDAPVVLD
LSYASRTTVAPEAAAGRRVSKAWLIRWSLLVQDRGKRALELALLQGLLGENHLLTPV-SS
MPRFFQVLPPFSDLSTFVCIHMSGYCFYREDEWCAGFGLYVLSPTSPPVSLSFSCSPHTP
TYAHLAAMACGLERFGQSNLPVVFLTHCNWIFSLLWELLPLWKARGF-LSSDGAPLPHPS
LLSYIISLTSGLSSLPFIYRTSYRGSLFAVTVDNLAKQGAQGGGQWWNLPKDVPVP-VMT
PRTMGKRPNLLALQLSDSTLADIIAKLRAGQKLCGSSPFSSAFNSLSLDKESGLLMFKGD
KKPKVWVVPRQLRRDLIFSVHDIPMGAHQRPEETYKKLRFLGWWPGMQEHVKDYCRSCLF
CIPRNLTGNELKVIESPW---P--LRS--TAPWSNLQIEVVGPITISEEGHRHVLIVADP
NTRWVEAFPLKPYTHMAVAQVLLQHVFARWGVPVRLEAAQGPQFARHVLVSCGLALGAQV
TSLSRDLQFPCLVSSEAYWEFKRALKEFIFLHGKKWAASLPLLHLAFRASSTVATPFQVL
TGSEWRLAEPLWWEMSSANIEGLKMDVFLLQLIGELLELHWRAAEKGTEK---ADNRRFK
QETQEKEWNVGDQVLLLSLPRNGSSAKWVGPFYIGDRLSLSLYRVWGFPTPEKLGCIYPS
SLMKAFAKSGTPLSFKALEQ----

------------------------------------------------------------
--------------------------------------------------------ML--
-PSGVNPETTDRFTVGADA-EDMVLKQRPQVERIFRVRLSVLE---------KVFESSPH
IWMQLEGPQENVVRAKEYLKGLCNPEVWEEVSYPAALHCVFFGARGLF-LDCLCWGTSAH
----------M---VPQAPGSLLLGGLIEAFVMAQSRMEDLVERLRQDSLQGPLSRTSR-
EQITQAFKALVRSYEDEYSRALLDLPISVQKWLLNLAEEAREGQGLPE----TPLGE-ER
S----S-------VLFGNGSWED----PVRKT-LSKG----RDIRETSFPLGTSSVEQEE
VR------------------------------------------E-----GV--------
----------------------------------Y----AREEYLPSNSGERNSDRLWSM
KTRELAGE-------------------------------------KDWPTQ------KLS
E-----------QNRGTG----------------------------------GR-KGS--
---------LGREMGMERGK----------------TGTGNGT-LDRR---IVGKGDM--
VGR-----------------------------------------RTRTEYGVWKLSN--G
ESSPPVG-----------------------------------------------------
--------------HNLLG-----------------------------------------
--------------TQPTWLDSSKTGDGQP------------------------------
------------------------------------------------------------
-------VE----------LQE---------------PESSKG----S------------
---------------------------LDG------TTG-----GNYEVTKTQRFLEVLK
TPFSLNLTNVPGTAGLRHIIIDGSNVAMIHGLQSFFSCRGIALAVQYFWDRGHREI----
TVFLPQWRLRKDAKVKECDFLTKLQSLNLLSVTPSRIVDGKRITSYD-------DRYM-M
KLAEEKDGIIVSNDQFRDLSGESVKWAEIIRER--P-----------------------S
LLPFTFVGNI------FMVPDDPLGREGPTLDDFLKKPNGV-HECG-RLNEPFFPESEIQ
----------------------------------P-------------------------
----------------KQEQKKEDEGISG--LRRPRETEKLRHKLLEVFWGQDHKV---D
FIL---------------QQNPST-RDLNQLSEALLRLNF--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

------------------------------------------------------------
--------------------------------------------------------MLL-
--SGGKPPAQEWFMVQTKS-KPRVHRQRLQVQRIFRVKVTAFQ----------SRPDTPY
FWLQLEGPRENTGKAKEYLKGLCNPELWKEVRYPPVLHCAFLGAQGLF-LDCLCWSTLAY
----------L---VPGPPGSLMVGGLTESFTMTQNWLEELVARLRWGPAPMITPRGVWE
TEVTRAFGALVWIRCDKYAGDLLQLPPAVQELLLSLVRDAAGKEDI-IEWLGHFGISGTC
---PNP--------EIL-----I-------------------------------------
-CLARQQKESASLVTIKESPG---TLQEIGALN------RASEN--SKKTTSSGAAGSLT
---------QAQSPPA-------Q--ETADQLARDQSNKQ---GDETNSVGEEGTA--TQ
DTSSQDSENPTQA--------LLQQKQVPKNEER--ISLLL--PVSALSAYTSWKVWAPG
TA--------FGPSWPGT------IAATFWKIN---ELQS----LHLAWLLSQACLNFPF
WQ-RPTGPIQLKLPGRNPLPLKLEWKQKELVPLSSAGSPACRPGGDLG---RETALKHSP
RPEIPS-KIISLSVVPGGCGIKEKVSPGLLQVGQSSTS---------VGDKGI-SLSDCK
GLEKPFSLALSTEQ------GGSTAQERPLAQ-------VPEAPTVSETLQVATAAEVSN
VEHPPTGEGLPATPKVPTALKKPA-VYTEPTAPKVPS-----------------------
-------------APTEPAAPA-----------------------------TPTAPQTPT
AQKTPS----VKTLAGLQ-----------------------------TPKVQSETIATAG
SEVPKAPA--------------ASAVAGPTVDVAQLLS-EVQASKNRAIMLKVQGKP-GR
QGFQPSSTVPSRSKHQFLKEGLLGA-WEGSQRLSPH-SQ-----GTNIVTSFQRYNEALN
TPFEMNLSEEPGNPGLRRVVIDGSSVAMVHGLQHFFSCRGIAMAVQYFWNRGHREI----
TVFVPTWQLKKNRRVRESHFLTKLHRLKMLSITPSQLENGKKITTYD-------YRFM-V
KLAEETDGVIVTNEQIHILMNNS-KKLMV-KDR---------------------------
LLPFTFAGSL------FMVPDDPLGRDGPTLEEFLKKPNRLDMDIGNFLKV----WKTLP
PSSASISELSDD-ADAEPLEDPQDVEE-AGKEEGSLE----E------------------
-------------EPGIPKPDEEDEQDTNPVSVFGVECPSFSEEILQCLSLHDPSEGTLD
IDLLPVVSSPYLDVPWD--GKAPCQQVLAQLAQLNIPSNFTALSFFMGFMDSHRDVISDY
EDLVGPLHGLLKQKPDWQWNQEHEKSFLALKRALVCALCLSTPNPNLPFYLEVTVSQVSL
TASLHQEHSGRKHPIAYTSKPLLPDEDSEGPQSGGDSPYAVAWALKHFARCVGDNPVVLR
LSYASRTTVDNEAWDSRRASKAWLIRWSLLLQDKGKRELELSLLQGLLGENQLLTPP-SS
MPRVFQPLPPSSDLSTFICVHVSGYCFYRDDELCAGFGLYILSPTSPPVSLAFSCSPYTT
TYAHLAAVACGLERFGQSQHPVVFLTHCNWIFSVLWELLPLWRVRGF-LSSDGASLPHPS
LLSYIISLTSGFSPLPFIYRTSYRGSLFAVTVDTLAKQGAQGGGQWWDLPKDVPVP-MVT
PHPKGRKPNLLALQLSDTTLADIIAKLQAGQKLSGPSPFSSAFNSLSLDQDSGLLMFKGE
RHPRVWVVPRQLRRDLIFSVHDSPIGEHQGLEDTYKTVRLLGWWPGMQDHVRDYCRSCLF
CIPRNLIGGELKVIESPWP-----LRS--TAPWSSLQIEVVGPVTVSEEGHKHVLIVADA
NTRWVEAFPLKPYTHVAVAQVLLQHVFARWGVPIRLEAAQGPQFARHVLVSCGLALGAQV
TTLSRALQFPCLMSSEAYWEFKRALKEFIFLYGKKWAASLPLLHLAFRASTTEATPFQVL
TGGEMKLMEPVWWEMSRANIEGLKMDAFLLQLMRELLDLHWRVAEKASEK---AENRRFK
RESQENEWSVGDQVLLLSLPRNGSSAKWMGPFYIGDRLSLSLYRVWGFPVPDKLGCVYPS
SLMKAFPKHDTPLSLDVEQ-----

------------------------------------------------------------
--------------------------------------------------------MLL-
--SGGDPPAQEWFMVQTKS-KPRVQRQRLQVQRIFRVKLNAFQ----------SRPDTPY
FWLQLEGPKENMSKAKEYLKGLCSPELWKEVRYPQALHCAFLGAQGLF-LDCLCWSTLAY
----------L---VPGPPGSLMVGGLTESFIMTQNWLEELVGRLRWGPAALLTPRGIWE
AEVTRAFGALVWIRGDQYAGDLLQLPPAVQELLLSLVRDAAGKEDI-IEWLGRIGTSESC
---PDP-------EVLI-------------------------------------------
-CPPHQQKEGPAMVSVGDGPG---PFLEVGTLQ-----NRSPEH--SKRLTNLGATRALV
SGT------PGQNTQQ----------ETTSQLVRVDSNSQ---GS-TDSAREEGP---AQ
ATSSQDSANHTQA--------PSQQRQVQRVEDK--RPFQP--PVSALSMCPPWKAWTPG
PA--------FGPLWPGA------IAATFWRIN---ELHS----LHLAWLLSQACFSFPF
WQ-RPLGPIQFKLPGQNPLPLNLEWKQKELVPLPSMESPDCRPDGGPG---GDATLQNCP
RPETPR-KVMSLLVVSGGSGVKDKTSPGLPQIGPPLTSAPQLQAGSEPGDQGS-VQWDCK
GPEEGPS-VLPTGQGVP------TAQGGSVAQEGLTGQSAPDAQTVPETLEVPVAAAVPT
AQTPPTDQGLPAVPKVPTAEMMLA-VPTEPAALKVPS-----------------------
-------------VPTKPAAQG------GPA-AQKAAVGQPAS----AAQIVPATPKTAT
AQKTPA---AKTSPAA-KTPKAQTGPAAKTGST--APKGPVAP------------KAPAA
SKASRGPKT--------PAAQKTPTDPGPSLDAAKLLSEVQPLSRGNASLPKGHGES-RR
QGPQSSSTLTSGSQHQPQMEGLLGA-WEGAPRQPPRHPQ-----ANSTVTSFQRYHEALN
TPFELNLSGEPGNQGLRRVVIDGSSVAMVHGLQHFFSCRGIAMAVQYFWNRGHREV----
TVFVPTWQLKKNRRVRESHFLTKLHSLKMLSITPSQLENGKKITTYD-------YRFM-V
KLAEETDGIIVTNEQLHILMNNS-KKLMV-KDR---------------------------
LLPFTFAGNL------FMVPDDPLGRDGPTLDEFLKKPNRLDTDIGNFLKV----WKTLP
PSSASASEPSDG-ADPAPPEGLRNMEEVQEEKEER-QD----------D---EQ------
--REGQGVQ---EP------PEEDALDSSLASVFRAECPSLSEEILRCLSLQDPPDGALD
IDLLPAPASPYLGIPWD--EKTPCQQVLAHLAQLTIPSNFTALSFFVGFMDSHQDVIPDY
EALVGPLHSLLKQKPDWQWDWEHEKAFLALKRALVSALCLTAPNTQLPFRLEVTVSQVAL
TAVVYQEHSGRKHPVAYTSKPLLPDEESEGPQSGGDSPYAVAWALKHFSRCIGDTPVVLD
LSYASRATVDPEAPEGRRLSKAWLIRWSLLVQDKGKRALELTLLQGLLGENRLLTPA-SS
MPRFFQVLPPFSDLSTFVCIHMSGYCFYREDEWCAGFGLYVLSPTSAPVSLSFSCSPYTP
TYAHLAAVACGLERFGQSHLPVVFLTHCNWIFSLLWELLPLWRARGF-LSSDGAPLPHPS
LLSYIISLTSDLSSLPFIYRTSYRGSLFAVTVDTLAKQGAQGGGEWWNLPKDVPIP-VVS
PHTMGKRPDLLALQLSDSTLADIIAKLQAGQKLSGSSPFSSVFNSLSLDKESGLLMFKGD
KRPKVWVVPRQLRRDLIFSVHDLPLGAHQRPEETYKKLRLLGWWPGMQEHVRDYCRSCLF
CIPRNLIGSELKVIESVW---P--LRS--TAPWSNLQIEVVGPVTISEEGHKHVLIVADP
NTRWVEAFPLKPYTHTAVAQVLLQHVFARWGVPVRLEAAQGPQFARHVLVSCGLALGAQA
ASLSRDLQFPCLTSSDAYWEFKRALKEFIFLHGKKWAASLPLLHLAFRASSTQATPVQIL
TGDEVRLSEPLWWEMSSANIEGLKMDVFLLQLIGELLELHWRVTDKASEK---AENRRFK
RESQEKEWNVGDQVLLLSLPRNGSSAKWVGPFYIGDRLSLSLYRVWGFPTPEKLGCIYPS
SLMKAFAKSGTPLSFKVLEQ----

Query Results

"ENSGT00750000117218_4"

ENSGT00750000117218_4