Query Results 

--------------------MSTIPRHFGLKYKEESYMFKELEKVRQETKKDFLRFKQKL
ASKPAVDERPVHSLYAPGAAR-------PERVSCAAART---SRGSPSAKGPAMSAAALL
QEVLGGAPRPSGLGEAAAPGKTLSFRPRDFYLRSSAFLRHQTLKKPPVIASGFGTARPVV
LLPPPEPPVKRRACRVLGSSRHAAHRPVLDLGRGREEGQEVAPLSGPCMAKERKVSS---
-ISTEDGYTDVSSGRRKVR----------IRTHFMSESRAREAR-------EAAGLGAQG
EQESLPPSDAREAAWQALLPARVIPTSIEEIIASLQSEAQLASDQTIKELIRSILGQNYD
IRMEDISLMG-KMYRKTSSMQ-AETPEIQAEHRFQMGAEE---SQTSMHKELPEAMSSIL
QIEQED-IEWGT-SEVESTVFKPQEILQVQPAEELSKP--LEDGQPT-SDSKEAKRVSLT
AKSSEFLQIEGKEVKQMQKRV-----SLRPRKSSKPLCDKKLREKIPRDYSMPHLHDLCA
TIPAQELPIDLRLASRVYHTADRKGHNTLLGKFGTSFLDDHFTDEE-QADRILYGIPVMD
DNQEYVHIPLTPQGIPPELAQGTRERAHKPHLQVLGEEMCAYPEFTKLFWNTAAPKFSVP
ESVMKETLYPKYESVQASRLLTDKFSYKSSAIT--FRRHSRTNFWCFLSRKSASFENIQK
WFSAQPTQLRQVKSAVDLRKEDIIAPLEIKNDMQSSIKEVMFQKTKELKRQLQLTKQNKT
EEP-IPVKKNIDDIFDN-----MCEKHSLRNLSLTLIEASKKAGISYIVYPKKKKMKWK-
KRLKQQKLIFVYEELSKPPKSL--ERSTSHGILPEQKKYLFKVPLYERQIRCPSLPLYLN
FEKFFQTKGGIPEN------------IDPRTWAFDSLIADKDASTP-----VKE-----K
DDKISVPKDPPERVKEPPKL--KLSDDVESDLPQEVIKHYESEVKILTEEINDKTKYPAF

PF13181 // ENSGT00730000110941_0_Domain_0 (1021, 1050)

AYCRRGAIYRKLGKLQSAMNDLQRVMLLEPLFLNAYWQRHLIYLFQDKINEALDDLNYIH
KYNKNNTEAYLSKAEIYRGKKDVTMAILNYTQAIKCRPTDADIYFRRGEMYEIANKVLAI
DDFSKCIFYDPKRTDALLKRGLFYYENENWFAAIEDFTALLNIDHQNSQARTYRGIAYVK
RKFYKEATQDFSAAIHLDPNNWLALYYRGCLFRKSNPFRALQDYSVSALINDGYENLGCF
LHRGIVYAHLKLWLLAICDFETVISLERTTTLAYVNIGLIHLLYLDNYTEAIWQFSEAIR
IDPLCIQSYLCRAETY-FKLHKLKKAVNELSRAIHLQPDG-IQLYIRRGQYLLMMKCYDL
AKFTIYQVAEMDK---GLIEL--SPIQQALIYSFCENHDKAIEVLEGISWNRAEMTMYAL
LAKVQMKAKRTKE--AVKMLKKALDVISHSDKGPNTTAIS

PF00515 // ENSGT00730000110941_0_Domain_7 (1481, 1514)

ADCLYNLGLCYMEEGNLQMA
FDSFTKAVKANPDFAESFYQRGLCKVKLHKDSSILDFNRAITLNPKHYQ--AYLSRVAFY
GLKGRYSKAILNCNKAIKIYPESVRAYLYRGVLKYYNK-TYKLAITDLTTAISMDKNSYI
AFYNRALCYTKIRELQMALTDYGIVLLLDATETVKLNTFLNRGLIYLELDQYGFALEDFK
QAALISQTN--ESLCHATAMC----HHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSY
MECGHAEATKQAQKDFLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDIDPKN
YLAYEGRAVVCLQMGNNFAAMQDINAAVKINTT

PF13181 // ENSGT00730000110941_0_Domain_17 (1834, 1866)

AEFLTNRGVIHEFMGHKQNAMKDYQDA
ISLNPEYSLAYFNAGNIYFHHRQFSQASGYFSKALKFDPENEYILM-NRAITNT---ILK
KYEEAKGDFANVIESCPFW

PF00515 // ENSGT00730000110941_0_Domain_20 (1940, 1973)

AAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFR
AKVRCKIGLIEEAMADYNQALHLEDHNSVI

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-----------------M

PF13432 // ENSGT00730000110941_0_Domain_2 (1159, 1219)

KHGIYYFDRSILTTAIQDFTAVIREDPSNAQARLYRGRAYAK
QKQYRNAVQDLTAAIHLD

ENSGT00730000110941_0_Linker_2_3 (1219, 1307)

PSCWLAFYYRGCILREIDPKRALQDFSVSVLINDTRENFSSF
LHRGIIYSKQQQWSIAIRDFESVIALDSSIIFAYLSIGLILLLHLD

PF13414 // ENSGT00730000110941_0_Domain_3 (1307, 1339)

QYYEAIQQFTNAIK
IDPLNVRAYLCRAQAY-HKIHNLSNAVKDINRAIHLYPDK-SELRILRGQYLTESKKYEL
ASLCIHQLAEMSE---ESLQA--QPVQQALIQSFCQNHSKAMECLHAAATTHPEPSVFVL
LGKIQMKAEKTED--AVGSFKQAINLLMTSEKTLPPTFEAAETYYLMGLCYMEQMNLLQA
CDAFSTAIRLHSNYPDAFYQRGLCRMQLRQTKCIQDFNHTLVLCPSHFQ-

PF13181 // ENSGT00730000110941_0_Domain_9 (1551, 1582)

-AYMGRAAYY
GSKGRYSKAIMNCNEAIKIHPNSVEAYFYRGTLKYQNK-TFKAAIEDLSKTIDLDNTCIL
AYNNRAICYHQIKDFRKALKDYGIVLLHEVSKEIVL

PF13424 // ENSGT00730000110941_0_Domain_13 (1657, 1725)

QVFINRGLLYMELGDYANACEDFK
EAVLLSPGD--SQIFQAIGTC----HYRLNEFEEAVRSFNQALRLEPISVEAYIGRGNSY
MKHGQEAGLEQAQKDFLKAIHLNPMCTKARICLGYNLRALGKLRSAWNQLTVVIAIDSKC
DTAYEGRALISLQMGEIFSALQDINAALKLTTTAPLLTNRGVINQLMGHLSCAMKDYQQA
ISVDPNYALAYFSAANIYFHNRQFSQAYCYYSEVLKLEPRNESAIM

PF13181 // ENSGT00730000110941_0_Domain_19 (1907, 1933)

-NRAVTNT---ILK
NFEEAKEDFEKA

ENSGT00730000110941_0_Linker_19_20 (1933, 1941)

VCLCPFSA

PF13181 // ENSGT00730000110941_0_Domain_20 (1941, 1973)

AVYFNRANFYNALKQYELAEKDISTALSIQPNDAMMYRLR
ADIRAKLGFSREAVEDYKQAISIQEQTDYM

--------------------MSTIPKHFGLTAREESYMFKELEKIRQKTKKDYEQLRQRL
AARPTLNARYEDQEKEERPGTAGGSGEKKE-----HVSWAAKPSS--GAQSGERPAAADL
Q--------GAPHSARGSPGKPQRFSPRDFYMRSSAFRRHPPYKEAPAISPQVGTTRQVI
LLRPRSRRKRLREKGRGALVTKRVSKGR----------AQESPVLDVTHTRYRL-ASS--
-LSSLSSDVDESARLRRLR----------IRTHFQRDLVRWHH--------KPSSRSRRE
G------SSASQGTA-PLLGIRYLPKNIEEIIASLQSEAQQASDQTIKELIQSILGQNYD
IAMEDISLME-RMYLKPSQVQ-LEVPKEVEEKKFPPSITEHS-VVPSIYEELPETVSSIF
QVEQEEAMKWVD-IDENSVAFKSQETLDIVPPDDAGKP--LDSALPT-TDVKLTSQPTLK
VEPRGFMQIRGREVKPTYKSRPKKSLKPR--IYV-KPEDKKLIKKMPQAHLPSHLHDLCT
TVPTMELPVDLYLASRVYHTPDRKGHKAVLGLLGLPLLGDHCVDE--QRERLIYGVPVMS
EKQKYTGVTSVPAKKFPEPEQTNQWEASKANLQLSGEEVSAYPGISKMFWNLSAPKFALP
ESTIRETLYPKYESVQTSRLLTEKLS-VTKETEIIVNTSTKRSFKNLIIKKFASYENIQK
YSSAPYTRLKRSKSKFELRKEETPLPFIMKDDIDTNLEQLKYQKKKELEHQL--AKQRSS
LNLSRK------GSLES-----LQGSEDMKILSMSLIEASRKAGITYIVFPSKKKKLLK-
KRTKFQKMAHVYEKLSGPPKKI--QRSASHGVLPGERKYFLKVPLYERQIRCPSVPTLLN
FDKFAESRGGIPKN------------TDPWTWVLELFAKDKPRKTHTP-VA----SSV--
------QGDVPEPVIELSKL--ELSDHVKCNLPPEVIKYYKSEVEKLTQEIKSEKRILAF

PF13181 // ENSGT00730000110941_0_Domain_0 (1021, 1046)

AYCRRGAIYRKLGKLQSAMNDLQEA

ENSGT00730000110941_0_Linker_0_1 (1046, 1095)

IFQEPLFLNAYWHRHFIYLFQDKVNDALDDLNFIT
KYNKNHAEAYLSKA

PF13414 // ENSGT00730000110941_0_Domain_1 (1095, 1134)

EIFREKKDITLAILNYSQAIKCRPKDADLYFKRGEMYEKTNKVLAI
DDYSKCIYYNRKRSDALWKRGMFYFENGNWIGAVYDFTSLLKLDPYNSDARTYRGRAYFK
RNLYKQATQDFSAAIHLDPNNWVALYYRACLFRKSSPYRALQDYSVSVLINDGYDNLNCF
LHRGILYTQLKFWMLAICDFETVVSLERNATLAYINIGIIYLEHLDNYTEAFWWFTEAIK
VDPLYLQSYICRAETY-SKLHKLKRAVIELTRAIHLQPDA-IHLYIMRGQFLLMMKSYDL
AKFTIYQVAEMNK---GIIEM--SPIQEALIYSFCENHDKAIHILEGVIASKPDISTYAL
LAKAQMKAKRIKE--SVRLFKKALELYTFSDKGPVATSVS

PF00515 // ENSGT00730000110941_0_Domain_7 (1481, 1514)

AECLYNLGLCYMEEGNFQMA
FESFTKAVKANPEFAEAFYHRGLCKVKLNKQNSILDFNRALTLNPKHYQ--AYLSRVAYY
GLKGRYSKAILNCNEAIKLYPESVRAYICRGVLKYYNR-TYKLGITDLSTAIKMDKNNYT
AYYNRALCYTKIGEHQMALRDYGIVLLLDAGENIALNTVINRGLIYTELKQYGFALEDFK
QAALMSKTS--VSLCQATATC----HHRIKEFEGAVEFFTRAIKINPHYVDAYIGRGNSY
MEYSQEDAMIQAQKDFLKALHLDPSCLKARICLGYNLQAQGKFQKAWIHFTVGIESNPKS
YLAYEGRAVVCLQMSNYFAAMQDINCAIKINST

PF13181 // ENSGT00730000110941_0_Domain_17 (1834, 1866)

AEFLTNRGVIHEFMGQQQSAMADYQAA
ISLNPSYSLAYFNAGNIYLHHRQFSQASDYFSTALKFNPENEYALM-NRAVTNS---VLK
KYEEAEKDFSCAMERCPHWAALYFNRASFYVYLKKYKLAEEDLGIGLSLKPDEAIMYNLR
AQVRGKMGLIAEAMSDYNQALNLEECSTAM

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-----------------------------------------------------RMKCYGL
AKFTIYQVAEMTK---XXXXX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXE--AMRMFKKALDIFSHSDKGRNAVAASSDCLFHLGLCYMEEGNLQLA
FDSFTKAVKADPDF

PF00515 // ENSGT00730000110941_0_Domain_8 (1515, 1547)

AEGFYQRGLCKVKLHKDCSILDFNRAITLDPK

ENSGT00730000110941_0_Linker_8_9 (1547, 1548)

H

PF00515 // ENSGT00730000110941_0_Domain_9 (1548, 1583)

YQ--AYLSRVAYY
GLKGRYSKAILSCNEAIQIYPQ

ENSGT00730000110941_0_Linker_9_10 (1583, 1584)

S

PF00515 // ENSGT00730000110941_0_Domain_10 (1584, 1618)

VRAYLYRGVLKYYNK-TYKLAITDLTTAINMDKNSYI
AFYNRALCYTKINELQMALTDYGIVLLLDAGETVM

PF00515 // ENSGT00730000110941_0_Domain_12 (1656, 1689)

LNAFINRGLIYTELEQFSFALEDFK
QAALISKT

ENSGT00730000110941_0_Linker_12_14 (1689, 1692)

N--

PF00515 // ENSGT00730000110941_0_Domain_14 (1692, 1729)

VSLCQATAMC----YHRNKEFEEAVNFFTWAVKIDPYFLDAYIGRGNSY
MEYGHDEAIRQAQKEFLKALHFNPVY

PF00515 // ENSGT00730000110941_0_Domain_16 (1767, 1800)

TKARICLGYNLQAQGKFQKAWNHFTIAIEVDPKS
YLAYEGRAVVSLQMGDNFAAIQDINAAIKINTRAEFLTNRGVIHEFMGQQQNAMRDYQAA
ISLNPTY

PF07719 // ENSGT00730000110941_0_Domain_17 (1868, 1901)

SLAYFNAGNIYFHHRQFSQAIDYFSKALKFDPENECATM-NRAIANT---VLK
RYEEAKEDFARVVESCPFW

PF00515 // ENSGT00730000110941_0_Domain_20 (1940, 1973)

AAVYFNRAYFYCCLKQYELAEEDLSKALSLKPNDALVYNLR
AEVRGKIGLIDEAVADYNQALYLQEHASVV

--------------------MSTIPKHFGLTAREESYMFKELEKIRQKTKKDYEQLRQRL
AARPTLKARYEDQEKEERPGTAGGSGEKKG-----HVSWAAKPSS--GAQSGERPAAADL
Q--------GAPHSARGSPGKPQRFSPRDFYMRSSAFRRHPPYKEAPAIAPQVGTTRPVI
LLRPRSRRKRLREKGRGAPVTTRVSKGR----------AQESPVLDVTHTRYRL-ASS--
-LSSLSSDIDDSARLRRLR----------IRTHFQRDLVRWHH--------KPSSRSRRE
G------SSASQGTA-PLLGIRYLPKNIEEIIASLQSEAQQASDQTIKELIQSILGQNYD
IAMEDISLME-QMYLRPSQVQ-FEVPKEVEEKNFPPSITEHP-VVPSIYEELPETVSSIF
QVEQEEAMKWVD-RDENIAAFKSQETLDIVPPEDDGKP--LDSALPT-TDAKLTSQPTLK
VEPRGFMQIRGREVKPTYKSRPKKLPKPR--IYV-KPEDKKLIKKIPQAHLPSHLHDLCT
TVPTMELPVDLYLASRVYHTPDRKGHKAVLGLLGLPLLGDHCVDE--QRERLIYGVPVMS
EKQKYTGVTSVPAKKFPEPEQTNQWEASKANLQLSGEEVSAYPGISKMFWNLSAPKFALP
ESTIRETLYPKYESVQTSRLLTEKLS-VTKETEIIVNTSTKRSFKNLIIKKSASYENIQT
YSSAPYTRLKRSKSKFELRKEETPLPFIMKDDIDTNLEQLKYQKKKELEHQL--AKQRIS
FNLSRK------DSLES-----LQGSEDMKILSMSLIEASRKAGITYVVFPSKKKKLLK-
KGTKFQKMAHVYEKLSGPPKKI--QRSASHGVLPGERKYFLKVPLYERQIRCPSVPTILN
FDKFAESRGGIPKN------------TDPWTWVLELFAKDKPRQTHTA-VA----SSA--
------QEDVPEPVIELSKL--ELSDHVKCNLPPEVIKYYESEVEKLTQEIKSEKRNLAF

PF13181 // ENSGT00730000110941_0_Domain_0 (1021, 1046)

VYCRRGAIYRKLGKLQSAMNDLQEAIFQEPFFLNAYWHRHFIYLFQDKVNDALDDLNFIT
KYNKNHAEAYLSKAEIFRE-KDITLAILNYSQAIKCRPKDADLYFKRGEMYEKTNKVLAI
DDYSKCIYYNRKRSDALWKRGMFYFENGNWIGAVYDFTSLLKLDPYNSKARTYRGRAYFK
RNLYKQATQDFSAAIHLDPNNWVALYYRACLFRKSSPYRALQDYSVSVLINDGYDNLNCF
LHRGILYTQLKFWMLAICDFETVVSLERNATLAYINIGIIYLEHLDNYTEAFWWFTEAIK
VDPLYLQSYICRAETY-SKLHKLKRAVIELTRAIHLQPDA-IHLYIMRGQFLLMMKSYDL
AKFTIYQVAEMNK---GIIEM--SPIQEALIYSFCENHDKAIHILEGVIASKPDISTYAL
LAKAQMKAKRIKE--SVRLFKKALELYTFSDKGPVATSVS

PF00515 // ENSGT00730000110941_0_Domain_7 (1481, 1514)

AECLYNLGLCYMEEGNFQMA
FESFTKAVKANPEFAEAFYHRGLCKVKLNKQNSILDFNRALTLNPKHYQ--AYLSRVAYY
GLKGRYSKAILNCNEAIKLYPESVRAYICRGVLKYYNR-TYKLGITDLSTAIKMDKNNYT
AYYNRALCYTKIGEHQMALRDYGIVLLLDAGENIALNTLINRGLIYTELKQYGFALEDFK
QAALMSGTS--VSLCQATATC----HHRIKEFEGAVEFFTRAIKINPHYVDAYIGRGNSY
MEYSQEDAMIQAQKDFLKALHLDPSCLKARISLGYNLQAQGKFQKAWIHFTVGIESNPKS
YLAYEGRAVVCLQMSNYFAAMQDINCAIKINST

PF13181 // ENSGT00730000110941_0_Domain_17 (1834, 1866)

AEFLTNRGVIHEFMGQQQSAMADYQAA
ISLNPSYSLAYFNAGNIYLHHRQFSQASDYFSTALKFNPENEYALM-NRAVTNS---VLK
KYEEAEKDFSCAMERCPHWAALYFNRASFYVYLKKYKLAEEDLGIGLSLKPDEAIMYNLR
AQVRGKMGLIAEAMSDYNQALDLEECSTAM

--------------------MSTIPRHFGLKYKEESYMFKELEKVRQETKKDFLRFKQKL
ASKPAVDESPVHSLHAPGPAR-------PARVSCAAART---SRRYPPPKGPAMSAAAFL
QEVLGGAPRPSGLGEAAAPGKTQSFRSRDFYLRSSAFLRHPALKKPPVIASGFGTARPVV
LLPPPEQPVKRRARGVLESSRHAAPRRVFDLGREREESQEVAPLAGPCMAKERKASS---
-VSAEDGYTEASSGRRKVR----------IRSNFVSESGAREAR-------EAAGLGAQG
EQESWPPSDAREAAWQALLPSRVIPTSIEEIIASLQSEAQLASDQTIKELIRSVLGQNYD
ITMEDISLMG-KMYLKTSPMQ-AETPEIQAEYKFQMGAEE---SQMSVHKELPETMSSIL
QIEQED-IEWGP-SEAESIVFKPQEISQVQPAEELSKP--LEDGQPT-SDSKEAKWVSLT
AKSPEFLQIEGKEIKRMQKRK-----SLRPRKSSKPLCDKKLHKKIPQDYSMPHLHDLCT
TIPAQELPVDLRLASRVYHTANRKGHDTLLGKSGTSFLDDRFTDEE-QTDRILYGIPVMD
DNQEYVHSPPTPQGIPPELAQGTRERAHKPHLEVLGEEMCAYPEFTKLFWNTAAPKFSVP
ESVMKETLYPKYESVQASRLLTDKFSYKSSVIT--LHQHSRTNFWCFLPRKSASFESIQK
WFSAQPTQLRRVKSSADLRKEKIIAPLEIKNDMQSSIKEVMFQKAKELKRQLQLTKQNKT
EEP-NYVKENIDDIFDN-----MGKKHSLRNLSLTLIEASKKAGISYIVYPKKKKMRWK-
KRLKQQKLIFVYEELSKPPKSL--ERSASHGILPGQKKYLFKVPLYERQIRCPSLPLYLN
FEKFVQAKGGIPEN------------IDSRTWALDRLIEYKDASIP-----VKE-----K
DDKISVPKDPPERVKEPPKL--KLNDYVESDLPQEVIKYYESEVKILTEEINDKTKYPAF

PF13181 // ENSGT00730000110941_0_Domain_0 (1021, 1050)

AYCRRGAIYRKLGKLQSAMNDLRRVMLLE

ENSGT00730000110941_0_Linker_0_1 (1050, 1088)

PLFLNAYWHRHLIYLFQDKINEALDDLNYIH
KYNKNNT

PF13181 // ENSGT00730000110941_0_Domain_1 (1088, 1119)

EAYLSKAEIYRGKKDITLAILNYTQAIKCRPTDADIYFRRGEMYEITNKVLAI
DDFSKCIFYDPKRTDALLKRGLFYYENENWFAAIEDFTALLNIDHQNSQARTYRGIAYVK
RKFYKEATQDFSAAIHLDPNNWLALYYRGCLFRKSNPFRALQDYSVSALINDGYENLGCF
LHRGIVYANLKLWLLAVCDFETVISLERTITLAYVNIGLIHLLHLDNYTEAIWQFSEAIR
IDPLCIQSYLCRAETY-FKLHKLKKAVNELSRAIHLQPDG-IQLYIRRGQYLLMMKCYDL
AKFTIYQIAEMGK---GLSEL--SPMQQALIYSFCENHDKAIEVLDRISCNRAEMTMCAL
LAKVRMKAKRTKE--AVEVLKKALDAISHSDKGPDATAIS

PF00515 // ENSGT00730000110941_0_Domain_7 (1481, 1514)

ADCLYNLGLCYMEEGNLQMA
FDSFTKAVKANPDFAESFYQRGLCKVKLHKDSSILDFNRAITLNPKHYQ--AYLSRVAFY
GLKGRYSKAILNCNKAIKIYPESVRAYLYRGVLKYYNK-TYKLAITDLTTAISMDKNSYI
AFYNRALCYTKIRELQMALTDYGIVLLLDATETVKLNTFLNRGLIYVELDQYGFALEDFK
QAALISRTN--GSLCHATNASIFLFICRINEFEEAVNFFTWALKINPCFLDAYVGRGNSY
MEYGHDEATKQAQKDFLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKN
YLAYEGRAVVCLQMGNNFAAMQDINAAMKISTT

PF13181 // ENSGT00730000110941_0_Domain_17 (1834, 1866)

AEFLTNRGVIHEFMGHKQNAMKDYQDA
ISLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLM-NRAITNT---ILK
KYEEAKEDFANVIESCPFW

PF00515 // ENSGT00730000110941_0_Domain_20 (1940, 1973)

AAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFR
AKVRGKIGLIEEAMADYNQALDLEDYASVI

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-----------------------------------------------------MMKRYDL
AKFTIYQVAEMNK---GLIEL--SPTQQALIYSFCENHDKAIQVLEGVIMNKPEV

PF13181 // ENSGT00730000110941_0_Domain_6 (1436, 1466)

TMYAL
LAKTQMKAKRNKE--AMKMFKKALDIFSHSDKGADAVAVSADCLYHLGLCYMEEGSLQM-
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---------------------------------------TYKLAITDLTTAINMDKNSYI
AFYNRALCYTKINELRMALTDYGIVLLLDAGGTLILNTFINRGLIYTELGQFSFALEDFK
QAALMSKTN--VSLCQAT

PF13181 // ENSGT00730000110941_0_Domain_14 (1699, 1727)

AMC----CHRNKEFEEAVNFFTRALKIDPCFPDAYIGRGNSY
MEYGHEEATKQAQKDFLKALHVNPMYTKARIC

PF13432 // ENSGT00730000110941_0_Domain_16 (1773, 1829)

LGYNLQAQGKFQKAWNHFTIAIEVDPKN
YLPYEGRAVVCLQMGDYFAAIQDINAAI

ENSGT00730000110941_0_Linker_16_17 (1829, 1834)

KINTT

PF13181 // ENSGT00730000110941_0_Domain_17 (1834, 1866)

AEFLTNRGVIHEFMGQQQNAMRDYQAA
ILLNPTYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENECATM-NRAIANT---VLK
KYEEAKEDFAHVVESCPFWA

PF13181 // ENSGT00730000110941_0_Domain_20 (1941, 1973)

AVYFNRAYFYCCLKQYELAEEDLGKALSLKPNDALVYHLR
AEVRGKIGLTEEAMADYNQALDLQEHASVV

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-----------------LIEL--TPIQQALIYSFCENHDKAIEVLDGISSSRPD

PF00515 // ENSGT00730000110941_0_Domain_6 (1435, 1470)

ITMYAL
LAKAHLKAKRTKE--AMKMFKKALEVFSL

ENSGT00730000110941_0_Linker_6_7 (1470, 1481)

SDKGPNAVATS

PF00515 // ENSGT00730000110941_0_Domain_7 (1481, 1514)

ADCLYNLGLCYLEEGNLQMA
FEFFTKAVKTNPDFAEGFYQRGLCKIKLQKDNSILDFNRAITINPKHYQ--AYXXXXXXX
XXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXAYKLAITDLNIAVNMDKNN

PF00515 // ENSGT00730000110941_0_Domain_11 (1619, 1652)

YV
AFYNRALCYTKIKEFQMALIDYGIVLLLDAG

ENSGT00730000110941_0_Linker_11_12 (1652, 1656)

KTVT

PF00515 // ENSGT00730000110941_0_Domain_12 (1656, 1689)

LNTFINRGLIYRELEQYAFALEDFK
QAAVLSQT

ENSGT00730000110941_0_Linker_12_14 (1689, 1692)

D--

PF00515 // ENSGT00730000110941_0_Domain_14 (1692, 1729)

VNLCHATAMC----HHRIKEFEEAVDFFTWALKINSHFLDAYVGRGNSY
MEYGHDEATKQAQKDFLKALHLDPTYTKARISLGYNLQXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXHRQF-QASDFFSKALMFDPEN

PF00515 // ENSGT00730000110941_0_Domain_19 (1902, 1939)

EFALM-NRAIANT---ILK
KYEEAKEDFACVIKSCPS

ENSGT00730000110941_0_Linker_19_20 (1939, 1940)

W

PF00515 // ENSGT00730000110941_0_Domain_20 (1940, 1973)

AAVYFNRAHFYCCLKQYELAEEDLSKXXXXKPDDA-VYNLR
AEVRGKIGLIEEAIADYNQALGLEDYTSLM

--------------------MSTIPKRFGLSSRGQSYMFKELEKIRQETRKDYLRFKQTL
ATKQALGESADEDLED--------------EDEEAGPKGSGKKERLPSASRPSS------
-ERPAGKP----HGARGAPGPPPAFRPQDFYRRTWAFPRHGPPKKPPAIAQQAGTSKPVV
LLPQRWRRPRSRA----SSPRTRLSRRVMAPGPRREA-----PLLDVAGAGHRQ-AGS--
-DSSPGSEAEGSGWQRRSR----------I---------------------LPGARVLRG
GGLS----AQAPQAA-PLPPTRVLPKSIEDIIASVQSEAQLASDQTIKELVQSVLGQNYD
VTMEDISLME-QMYLRPSQMQ-IETAQMEAEPKSQMSTEEPPVKVMNIYEELPEAVSSVF
QIEQEDILEWGT-LEEENIAFKSQEISDIQPAEDSSKPKPSEADHPA-GDTKALK----R
VKSSEMLQIRGREVKRTRKSQPV-IP-LRPRMPLRPHQDKKLIKKIPQGFRFPHLHDLCN
MVPAEELPIDLRLASRVYHTPNQKGHNTLLRLLGSSFLGDHFVD-E-QRDRILYGVPVKS
GKQKYVSVAP-KPEKSPELARRTQQHTPKPGLQLLGEEVTAYPGPTKMFWNLTAPKFAVP
ESTMRENLYPKYECVQTSRILSEKFLSESKESVVILDTY--RSFKSLIIRKSASFQNISK
QSSIPYKRLKRSQSVGELRKKETVPAFVIKDDTKNNMKQLLFQKARGLERQL--ARQRGI
TGPPME------GSSES-----LQESHSLKYLSLSLIEASRKAGISYIIYPRKMKKKWK-
KGLKFPKLAYVYEQLSKPPNKM--ERSTSHGILPGQKKYLLKVPLYERQIRCPSVPMFLN
FDKFVKSKGGVPEN------------SDLRTWALETFTKDKQQKTPPP----V--IAA--
------PQDLPKQAVESLKL--ELSDHIKCDLPLELIKYYESEVEALTEEINQEKRIPVF
AYCRRGAIYRKLGKLQSAMNDLQETIFMEPLFLNAYWHRHFIYLFQDRINDALDDLNYIN
KYNKNNAEVYVSKA

PF13414 // ENSGT00730000110941_0_Domain_1 (1095, 1133)

EIFREKKDFTLAILNYSQAIKCRPTDADLYFRRGEMYERTNRVLAI
DDYSKVSFIY---------------------------------------NKTYRGKAYFR
RNFYKQATQDFSVAIHLDPNNWLALYYRACLFRKSNPYKALQDYSVSALINDGYENLSCF
LHRGIVYTHLKLWMLAICDFETVIALERTSILAYINIGLIHLLHLDNYTEAFRKFSEAIK
IDPLYIQSYICRAETY-NKLHKLKNAVSELSRAIHLQPDG-IQLYLIRGQYLLMMKCYDL
AKFTIYQVAEMNK---GLIEL--SPIQQAVIYLFCENHDKAIQVLDGVTCNRPEIA

PF13181 // ENSGT00730000110941_0_Domain_6 (1437, 1467)

TYAL
LAKAQMKAKKTKE--AVRIFKKALEI

ENSGT00730000110941_0_Linker_6_7 (1467, 1481)

YAHSDKGPHATAIS

PF13181 // ENSGT00730000110941_0_Domain_7 (1481, 1513)

ADCLYNLGLCYMEEGSLQMA
FDSFTKSVKANPEFAEAFYQRGLCKIKLNRDNSILDFNRAITLNPKHYQ--SYLSRVAYY
GLKGRYSKAILNCNEAIRLYPESVHAYICRGVLKYYNK-SYKLAITDLTTAINMDKNSYI
AFYNRALCYTKIRELEMALRDYGIVLLLEAAETITLNSYINRGLIYTEQEHYGFALEDFK
QAALISQTS--VSLCQATAMC----HHRIKEFEEAIDFFTKVIKMNVCFLDAYVGRGNSY
MEFGHEEATKLAQKDFVKALHINPSCRKARI

PF13432 // ENSGT00730000110941_0_Domain_16 (1772, 1827)

SLGYNLQAQGKFQKAWNHFTIAIEADPKN
YLAYEGRAVVCLQMSNSFAAIQDINT

ENSGT00730000110941_0_Linker_16_17 (1827, 1834)

ALKINTT

PF13181 // ENSGT00730000110941_0_Domain_17 (1834, 1867)

AEFLTNRGVIHEFMGQQQNAMRDYQAA
ISLDPKCALAHFNAGNIYFHHRQFSQASDYFSKALQFNPKNDYALM-NRAVANT---MLE
KYEEAKEDFSRAIENCPNWA

PF13181 // ENSGT00730000110941_0_Domain_20 (1941, 1972)

ALYFNRASFYFCLKQYELAEEDLSKALSLKPDEALMYYLR
AEVRGKIGRMEEAMADYNQALDLEEYVSTK

--------------------MSTIPRHFGLKYKEESYMFKELEKVRQETKKDFLRFKQKL
ASKPAVDESPVHSLYAPGAAR-------PARVSCAAAQT---SRGSPPAKGPEMSAAALL
QEVLGGAPCPSGLGEAAAPGKTWSFRPRDFYLRSSPFLRHQALKKPPVIASGFGTARPVV
LLPPPEPPMKRRACRVLGSSRHAAPRPVLDLGRGREESQEVAPLSGPCMAKERKVSS---
-VSAEDGYTDASSARRKVR----------IRTHFVSDSRAREAR-------EAAELGAQG
EQESWLPSDAREAAWQALLPARVIPTSIEEIIASLQSEAQLASDQTIKELIRSILGQNYD
IRMEDISLMG-KMYLKTSSMQ-AETPEIQAEHRFQMGAEE---SQTSMQKELPEAMSSIL
QIEQED-IEWGT-SEVESTVFKPQEISQVQPAEELSKP--LEDGQPT-SDSKEAKRVSLT
AKSSEFLQIEGKEVKQMQKRK-----SLRPRKSSKPLCDKKLREKIPRDYSMPHLHDLCT
TIPAQELPTDLRLASRVYHTANRKGHDTLLGKFGTSFLDDRFTDEE-QTDRILYGIPVMD
DNQECVHIPLTLQGIPPELAQGTRERAHKPHLQVLGEKMCAYPEFTKLFWNTAAPKFSVP
ESVMKKTLYPKYESVQASRLLTDKFSYKNSAIT--LRRHSRTNFSCFLPRKSASFENIQK
WFSAQSTQLRQVKSAVDLRKEDIVVPLEIKNDMQSSIKEVMFQKAKELKRQLQLTKQNKT
EEP-ISVKKKINDIFDN-----MCEKHSLRNLSLTLIEASKKAGISYIVYPKKKKMKWK-
KRLKQQKLIFVYQELSKPPKSL--ERSTSHGILPEQKKYLFKVPLYERQIRCPSLPLYLN
FEKFFQTKGGIPEN------------IDPRTWAFDRLIAHKDVSTP-----VKE-----K
DDKISVPKDPPERVKEPPKL--KLSDDVESDLPQEVIKHYESEVKILTEEINDKTNYPAF

PF13181 // ENSGT00730000110941_0_Domain_0 (1021, 1050)

AYCRRGAIYRKLGKLQSAMNDLQRVMLLE

ENSGT00730000110941_0_Linker_0_1 (1050, 1088)

PLFLNAYWHRHLIYLFQDKINEALDDLNYIH
KYNKNNT

PF13181 // ENSGT00730000110941_0_Domain_1 (1088, 1119)

EAYLSKAEIYRGKKDITMAILNYTQAIKCRPTDADIYFRRGEMYEIANKVLAI
DDFSKCIFYDPKRTDALLKRGLFYYENENWFAAMEDFTALLNIDPQNSQARTYRGIAYVK
RKFYKEATQDFSAAIHFDPNNWLALYYRGCLFRESNPFRALQDYSVSALINDGYENLGCF
LHRGIVYAHLKLWLLAICDFEAVISLERTTTLAYVNIGLIHLLHLDNYTEAIWQFSEAIR
TDPLCIQSYLCRAETY-FKLHKLKKAVNELSRAIHLQPDG-IQLYIRRGQYLLMMKCYDL
AKFTIYQVAEMDK---GLIKL--SPIQQALIYSFCENHDKAVEVLDGISWNRPEMTMYAL
LAKVQMKAKRTKE--AVKMLKKALDVISHSDKGPNTTAIS

PF00515 // ENSGT00730000110941_0_Domain_7 (1481, 1514)

ADCLYNLGLCYMEEGNLQMA
FDSFTKAVKANPDFAESFYQRGLCKVKLHKDSSILDFNHAITLNPKHYQ--AYLSRVAFY
GLKGRYSKAILNCNKAIKIYPESVRAYLYRGVLKYHNK-TYKLAITDLTTAISMDKNSYI
AFYNRALCYTKIRELQMALADYGIVLLLDATETVKLNTFLNRGLIYVELDQYGFALEDFK
QAALISQTN--ESLCHATAMC----HHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSY
MECGHDEATKQAQKDFLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDIDPKN
YLAYEGRAVVCLQMGNNFAAMQDINAAMKINTTAEFLTNRGVIHEFMGHKQNAMKDYQDA
IYLNPKYS

PF07719 // ENSGT00730000110941_0_Domain_17 (1869, 1901)

LAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYILM-NRAITNT---ILK
KYKEAKEDFANVIESCPFW

PF00515 // ENSGT00730000110941_0_Domain_20 (1940, 1973)

AAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYKFR
AKVRCKIGLIEEAMADYNQALALEDHDSVI

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-----------------------------------------------------KMKRFDL
AKFTIYQVADMNK---GLLEL--SPVQQALIYSFCKSHDKAIQVLQALTLSKPELTTFAL
LAKAQMKAKRNKE--AVRTFKKALGGISKSDKGPNAVTAS

PF00515 // ENSGT00730000110941_0_Domain_7 (1481, 1514)

ADCLYHLGLCYMEEGNLQMA
FDSFTKAVKANPDFAEGFYQRGLCKVKLHRSSSILDFNRAITLNPKH

PF00515 // ENSGT00730000110941_0_Domain_9 (1548, 1583)

YQ--AYLSRVAYY
GLKGRYSKAILNCNEAIKIYPE

ENSGT00730000110941_0_Linker_9_10 (1583, 1584)

S

PF00515 // ENSGT00730000110941_0_Domain_10 (1584, 1618)

IHAYLYRGVLKYYKK-TYKLAITDLSIAIRMDKNSYI
AFYNRAICYTKINELQMXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX----XXXX
XXXXXXXXX--XXXXXXXXXXXXXXXXXID

PF00515 // ENSGT00730000110941_0_Domain_14 (1711, 1729)

EFEDAVNFFTNALKINPHFVDAYVGRGNAY
MEYDQNEATKQAQKDFVKALHFNPMH

PF00515 // ENSGT00730000110941_0_Domain_16 (1767, 1800)

TKARISLGYNLQAQEKFQKAWNHFTIALEIESKN
YIAYEGRAMVCLQMGNNFAAIQDINAAIKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXAGDYFSKALVFDPKD

PF00515 // ENSGT00730000110941_0_Domain_19 (1902, 1929)

DCALM-NRAVINT---ILK
KYEEAEKD

ENSGT00730000110941_0_Linker_19_20 (1929, 1940)

FANIVDNCPLW

PF00515 // ENSGT00730000110941_0_Domain_20 (1940, 1973)

AAVYFNRANFYYCLNQYEIAEADLTKALSLKPNDPLAYNLR
AKVRGKIGLIEEAMADYNQALDLQEYASVI

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------------E--ALKMFKXXXXXXXXXXXXXXXXXXXXDCLYHLGLCYVEEGNSQMA
YDCFTKAVKAKPDF

PF00515 // ENSGT00730000110941_0_Domain_8 (1515, 1547)

AEGFYQRGLCKVKLGKNYPILDFNRAITLDSN

ENSGT00730000110941_0_Linker_8_9 (1547, 1548)

H

PF00515 // ENSGT00730000110941_0_Domain_9 (1548, 1583)

YQ--AYLSRAAYY
GLKGRYSKAILNCNEAIKICSQNVFAYIYRGVLKYYNK-TYKLAIKDLTIAVSMDKNS

PF00515 // ENSGT00730000110941_0_Domain_11 (1619, 1652)

YI
AFYNRAICYTQVSEYAKALIDYGIVLLLDSG

ENSGT00730000110941_0_Linker_11_12 (1652, 1656)

ETIV

PF00515 // ENSGT00730000110941_0_Domain_12 (1656, 1689)

LNTFINRGRIYTELKQYHFALEDFK
TAAEMQKT

ENSGT00730000110941_0_Linker_12_14 (1689, 1692)

N--

PF00515 // ENSGT00730000110941_0_Domain_14 (1692, 1729)

ANFYYATAEC----HYRIKEFEEAVHFFSHALSLDIHFLDAYIGRGNSY
VEYGDDKATKQAQKDFIRALHFCPSYLRARICFAYNLQXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXAVVCLQMGDYFAAIQDINIAVKINTT

PF00515 // ENSGT00730000110941_0_Domain_17 (1834, 1867)

AEFLTNRGVIHEFMGQQQNAMKDYQAA
LSLNPTYSLAYFNAGNIYFHHRQFSQXXXXXXXXXXXXXXXXXXXXXXXXXXXX---XXX
X-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXLSLKPND

PF00515 // ENSGT00730000110941_0_Domain_21 (1974, 2007)

TLIYNLR
AEVRGKLGHISEAMADYNKALDLQDYALVK

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--------------------------------------TEADLYFRRGEMYETENKMLAI
DDFSKCIFYDPKRTDALFKRGMFYYENENWIAAEQDFTALLKIDPQNSQARMYRGRAYFK
RNFYKQAVQDLSIAVHLDPNNWLALYYRACLFRKSNPLRALQDYSVSALINDGYENLSCF
LHRGILYADLKLWLLAICDFEAVISLERTMTLAYINIGLINLLHLDNYIEATSYFSEAIR
YDPMYIQSYICRAEAY-NKLHKLKKSVRELSYAIHLQPDG-IQLYIIRGQYLLKMRCYDL
AKFTIYQVAEMNK---GLIEL--SPIQQALIYSFCENHDKAIQVLDGITLNKPDISMCTL
LAKAQMKAKRNKE--AMRMFKKALDLISYSDKGPSSLAAS

PF07719 // ENSGT00730000110941_0_Domain_7 (1481, 1513)

ADCLYHLGLCYMEEGNLQLA
YDSFTKAVKANPDFAESFYHRGLCKVKLHKNGSILDFNRAITLDPKHYQ--AYLSRVAYY
GLKGRYAKAILSCNEAIKIYPQSVRAYVYRGVLKYYSR-TYKLAITDLTTAINMDKNSYI
AFYNRALCYTKINELQMALTDYGIVLLLNAGETVTLN

PF00515 // ENSGT00730000110941_0_Domain_12 (1658, 1685)

TYINRGLIYAELEQFSFALEDFK
QAALISKTN--VSLCQATAMC----YHRNKEFEEAVNFFTWAVKIDPRFLDAYIGRGNSY
MEYGHEEATKQAQKDFLKALHFNPAYTKARICLGYNLQAQGKFQKAWNHFTIAMEVDPKS
YLAYEGRAVVCLQMGDNFAAFQDINAAIKINGTAEFLTNRGVIHEFMGQQQNAMRDYQEA
ISLNPTYSL

PF00515 // ENSGT00730000110941_0_Domain_17 (1870, 1901)

AYFNAGNIYFHHRQFSQASDYFSKALKFDPENECATM-NRAIANT---VLK
RYEEAKEDFAYVAESCPLW

PF07719 // ENSGT00730000110941_0_Domain_20 (1940, 1973)

AAVYFNRAYFYCCLKQYELAEEDLSKALSLQPNDALIYNLR
AEVRGKIGLIEEAMADYNKALDLQECASVV

--------------------MSTIPKHFGLKYKEESYMFKELEKVRQETKKDFLRFKQKL
ASKPGVGEGPLHNPHAPSPAR-------RTRLSRAGVRT---SRGSSPAKGPARSAAALL
QEVLGGAPRPSGLGEAAAPGKTRPFLPRDFNLRSSAFLRHLPQKKPPVIASGFGTARPVV
LLPPPEPPAKRRD---LESPRLAGPRRVLDLARGREESQAVAPLAGPCKARERKVSS---
-VSAGDGSAEAGGGRRKVR----------IRTCFGSESLAREAP-------EAAGSRTRG
ERESWPPCDTREAAGQALLPARVVPTSIEEIIASLQSEAQLASDQTIKELIRSVLGQNYD
IKMEDISLMG-KMYLKTSSIQ-AETPQIQAEHSFQMGAEE---SQMSMRKELPEAISSIF
QIEQEG-IERGP-LEVESTIFKPQETLQVQPAEELSKP--LEHGQPT-SDSKEAKPMPLK
AKSSEFLQIKGKQIKQMRKCK-----SLRPRKSSKPLCDKKLQRKIPRDYSMPHLHKLCT
TIPARQLPVDLCLASRVYHTANRKGHNALLGIFGTSFLDDRFTDEE-QTERILYGIPVMD
DNQEHVHVPPTPRGIPPELAQGTREHVHKPHLQVLGEEMCAYPEFTKLFWNTAAPKFSVP
ESVMKETLYPKYESVQASRLLTEKFSPDISVLT--LHQYSRTNFSCFLLRKSASLESVQK
CFSAQPTQLRRAKSSVDLRKEEIIAPLEIKNDMQSSIKEVLFQKANELKRQLQLLKQNKT
EDP-IPVKENVDHIFEN-----ICEKHSLRNLSLSLVEASKKAGMNDIVYPKKKKTKWK-
KRLKQRKLTFVYEELAKPPKSL--ERSESHGILPEQKKYLFKVPLYERQIRCPSLPLYLN
FEKFVQMKGGIPEN------------SDPRTWALDMLVEHKYQRTP-----IKE-----E
VDKISVLKDSPEIVKEPPKL--KLNDNVESNLPPEVIKHYESEVKILTEEINNKTEYPAF

PF13181 // ENSGT00730000110941_0_Domain_0 (1021, 1050)

AYCRRGAIYRKLGKLQSAMNDLQKAMLLE

ENSGT00730000110941_0_Linker_0_1 (1050, 1088)

PFFLNAYWHRHLIYLFQDKINEALDDLN-IH
KYNKNNT

PF13181 // ENSGT00730000110941_0_Domain_1 (1088, 1119)

EAYLSKAEIYRGKKDITLAILNYTQAIKCRPTDADIYFRRGEMHEIANKVLAI
DDFSKCIFYDPKRTDALLKRGLFYYENENWFAAIQDFTALLNIDHQNSQARTYRGMAYVK
RKFYKQATQDFSAAVHLDPNNWLALYYRGCLFRKSNPFRALQDYSVSALINDGYENLSCF
LHRGIVYAHLKLWLLAICDFETVISLERTITLAYINIGLIQLLHLDNYTEAIWQFSEAIR
IDPLCIQSYICRAETY-FKLHKLKKAVNELSRAIHLQPDG-IQLYIRRGQYLLMMRCYNL
AKFTIYQVAEMDK---GLNEL--SPIQQALIYSFCENHDKAIEVLDGISWNRTDMTMYAL
LAKVQMKAKRTKE--AVRTLKKALDVISHSDKGPNATAIS

PF00515 // ENSGT00730000110941_0_Domain_7 (1481, 1514)

ADCLYNLGLCYMEEGNLQMA
FDSFTKAVKANPDFAESFYQRGLCKAKLHKDSSILDFNCAITLNPKHYQ--AYLSRVAFY
GLKGRYSKAILNCNMAMKIYPDSVRAYLYRGVLKYYNK-TYKLAITDLTIAINMDKNSYI
AFYNRALCYTKIRELQMALTDYGIVLLLDATETVKLNTFLNRGLIYIELGQYGFALEDFK
QAELISQTN--GSLYHATAMC----HHRINEFEEAINFFTWALKINPCFLDAYVGRGNSY
MEYGLDEATKKAQKDFLKALHINPGYIKARISLGYNLQIQGKFQKAWNHFTIAMDIDPKN
YLAYEGRAVVCLQMGNNFAAMQDINAAMKINTTAEFLTNRGVIHEFMGHKQNAMKDYQEA
ISLNPKYS

PF07719 // ENSGT00730000110941_0_Domain_17 (1869, 1901)

LAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLM-NRAIANT---ILK
NYEEAKEDFANLIERCPFW

PF00515 // ENSGT00730000110941_0_Domain_20 (1940, 1973)

AAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFR
AKVRGKIGLSEEAMADYNQALDLEDYASFT

--------------------MSTIPKHFGLTSRDESYMFKELEKIRQEYKKEYFEFKQLS
A-RQALGASSEDDLEDEDEEARPLSAQAKGQV-----SWAVKLASSSRAQSPERPAAADL
Q--------GAPPSARRRPVKPQPFRPREFYLRSSAFLRHRPQKEAPAICPQVGTARPAI
LMRPRSRQRKLHVKPR----REPVSRPKIVLSPEHED-----PGLEVARPRYRL-ASS--
-LSSLGSEVDDSGRLRRLR----------IHTHFMREGMGASR--------WLRPRSKSG
REGG----STIQANW-SMPVTRYIPTSIEEIIASLQSEAQLAADQTIKELIQSILGQNYD
LTLEGISLIE-QRYLRSTQSH---TFKAEEEKEIQIPV------PTRISEEPSEAVSSIF
QIEQEDVFEWGT-IGEENLRFKSQEMLETVPLEDSSEP--LEGDVST-TAKEKSKQKSLK
VKSTEFLQIRGTEAKRIQKSRPIVKPLKSRKFVRRYREDKKRMKKIPQGYPLPHLHHLCT
RVPTLELPMNLRLASRVCHTSDRTGHKPMLGLLGSSFLSDCSIDE--QRDRILNGVPVKS
ETQKYVSVPSPPPEEFPESMQTRQCQAHTPNLQLLGEEVPAYPGASKMFWNLTAPKFSIP
ESTMRETLYPQYESIQTSRILTEKLS-ESKESVIILNTYTRRSFQNFLIKKSASCGNIQE
YPSAPHTWLKRSKSVVELRKEE-SPPFVLKDDIDTNLKQLRYQKKKELEHQL--ARQRAT
LEPTFK------SSLET-----LKESDSLKYLSFSLVEASRKAGFSYIVYPRKKKGLWKK
KGLKFQKLALVYEYLSRPPKKL--ERSASHGILPGQKKGLLKVPIFEQQIRCPSVPMVLN
FDQFAKNKGGIPEN------------TDPRKWVLEIFAKDKPQKTPAPVVQ----KVV--
------QKEVREPVAELPKL--ELSDHPKCNLPPEVIQYYESEVEKLTQEIKNEKRIPVF

PF13181 // ENSGT00730000110941_0_Domain_0 (1021, 1046)

AYCRRGAIYRKLGKLQSAMNDLQKA

ENSGT00730000110941_0_Linker_0_1 (1046, 1095)

IHAEPLFLNAYWHRHFLYLFQDKTTDALDDLNFIH
KYNKNNAEAYMSKA

PF13414 // ENSGT00730000110941_0_Domain_1 (1095, 1132)

EIFREKNDLTLAILNYSQAIKCRPKDADLYFKRGEMY

ENSGT00730000110941_0_Linker_1_2 (1132, 1159)

ELTNKLLAI
DDFSKCIYYDRTRTDALM

PF13432 // ENSGT00730000110941_0_Domain_2 (1159, 1221)

KRGTYYFDNENWIGAIHDFTSLLKLVPQNCQARTSRGRAYFK
KNLYRQAIQDLSVAIHLDPNNWLALYYRACLFRKCSPLRALQDYSVSVLINDGYDNLNCF
LHRGILYTQLKLWMLAICDFETVISLERTATLAYINIGLIYLLHLDNYTEAFTRFSEAIR
IDPLYIQSYICRAETY-YKQHKFKRAVCELSRAIHLHPDE-IQLYIMRGQYLLMMKCYDL
AKLTIHQMAEMNK---GLIEL--TPIQKALIYLFCENHDKAIQILEVVTASKPEISTFAL
LAKAQMKAKKIKE--AVRTFKKTLEMLTSSRKGQDAINISS

PF13181 // ENSGT00730000110941_0_Domain_7 (1482, 1513)

ECLYNLGLCYMEEGSLLMA
HDSFTKAVNANPDFAEAFYQRGLCKVKLNKDSSILDFNQAITLNPGHYQ--AYLSRVAYY
GLKGRYSKAILNCNEAIRLYPESVRAYICRGVLKYYNR-TYKLAITDLTTAVNMDKNSYI
AFYNRALCYTKIKDLDMALRDYGIVLLLNAGERITLNTFINRGLIYTELKLYGFALEDFK
QAALLSQTS--VNLCQATAMC----HHRIKEFEGAVDFFTRAVNINSCFLDAYIGRGNSY
MEYEQDKALKLAQKDFLKALHIDPSSLKARISLGYNLQIQGKFQKAWNHFTIATEIYPKS
CLAYEGRAVVCLQMSDYFAAMQDINTAIKIDTT

PF13181 // ENSGT00730000110941_0_Domain_17 (1834, 1866)

AEFLTNRGVIHEFMGRKQNAMTDYDAA
ISLDPEYSLAYFNAGNIYFHHRQFSQANDYFSKALEFNSENEYALM-NRAVTNI---ILK
KYEEAEKDFSCAIEHCPHW

PF13181 // ENSGT00730000110941_0_Domain_20 (1940, 1972)

ATLYFNRASLYFCLKKYELAEKDLGVALSLNPSESALYNLR
AQVRGKIGLIAEAMSDYNQALDLEECPSAM

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------------------------------MQIIFNCFDL-KSVISSRGQYLLKMRCYDL
AKFTIYQVAEMNK---GLIEL--SPIQQALIYSFCENHDKAIQVLDGITLNKPDI

PF13181 // ENSGT00730000110941_0_Domain_6 (1436, 1466)

PMCTL
LAKAQMKAKRNKE--AMRMFKKALDLISYSDKGPSSLAASADCLYHLGLCYMEEGNLQLT
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----------------------------------------YKLAITDLTTAINMDKNSYI
AFYNRALCYTKINELQMALTDYGIVLLLNAGETVTLNTYINRGLIYAELEQFIFALEDFK
QAALISKTN--VSLCQATAMC----YHRNKEFEEAVNFFTWAVKIDPRFLDAYIGRGNSY
MEYGHDEATKQAQKDFLKALHFNPAYTKARICLGYNLQAQGKFQKAWNHFTIAMEVDPKS
YLAYEGRAVVCLQMGDNFAAFQDINAAIKINGTAEFLTNRGVIHEFMGQQQNAMRDYQEA
ISLNPTYS

PF00515 // ENSGT00730000110941_0_Domain_17 (1869, 1901)

LAYFNAGNIYFHHRQFSQASDYFSKALKFDPENECATM-NRAIANT---VLK
RYEEAKEDFAYVAESCPLW

PF07719 // ENSGT00730000110941_0_Domain_20 (1940, 1973)

AAVYFNRAYFYCCLKQYELAEEDLTKALSLQPNDALIYNLR
AEVRGKIGLIEEAMADYNKALDLQEHALVV

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-----------SLYNFL--K-SEPSPKILTNNKNIFCIYL---SQQSMSEELLDEGSSTF
QIDQDGVSDRPS-LDAEDIAFKFQDSLEMHPAEEPTER--RNISYVA-TSLNGTLYTFLK
VQSSEFLQIIGKEVKRPRRSKSE-TPPQRRKKYLKPQVDPRLLKKIPQARPTPHLHHLCT
ATPARQLPLDLHLASRVYHTADKKGHSAPLGIFGPSFLGDLFADT--QRDRILYGIPLMD
EQQESVSNAPVPPRLTPEIAWRMRWRFHNPHLELLGQEMSAYPGCTKMFWNPAAPKFAVP
ESVMKETVYPQYECVQRSRILTKKFLSDGKESVAFNYN--SLNFKSRT-----------T
KYIFLFFLIKRAKSSVELRRQEAIAPMEIKDDIQSNIKVVMFQKAKELEHRL--ASVSV-
------------SVKES-----IDEEYNSVDLSRFLTEASRQAGITYIVYPKKKKTKWK-
KSLKSEKLTIVCEELSKPPNMI--KRSTSHGILPGQKKYLLKVPLYERLTRSPSLPMSLN
FDKFVGRRGGMLET------------RDPYMWAHDTLFRSKLQKIATKVD--E--MTI--
------KRDLSESAEEPPNV--QLSDSLECDLPPEVIKHYESEVEILTEEINEKKTFPAF

PF13181 // ENSGT00730000110941_0_Domain_0 (1021, 1050)

AYCRRGAIYRKLGKLQSAMSDLQEAILLE

ENSGT00730000110941_0_Linker_0_1 (1050, 1095)

PLFLNAYWHRHFIYLFQDKINEALEDLNYIS
KYNKNNADAYLSKA

PF13414 // ENSGT00730000110941_0_Domain_1 (1095, 1133)

EIYRKSNNITLAILNYTQAIKCRPTNADIYFRRGEVYEKENRVLAV
DDFSKCIFYDPKRTDALMKRGKFYSENENWISAIQDFTALLNIEQKNSEAWTYRGKAYFR
RHLYKQATQDFSVAIHLDPNNWVALYYRACIFRKNNPLRALQDYSVSALINDGYENLSCF
LHRGILYAHLKFWLLAICDFETVISLERTFTLAYINIGLIHMLHMDNYTEAIWHFSEAIR
VDPLYIQSYMCKAEAY-YKLHKWKSAVNELSRAIHLQPDR-IQLYIIRGQYLLMMRCYDL
AKFTIYQVAEMNK---GLIGL--SPIQQAHIYSFCENHDKAIQVLEGMSGHRSEM

PF13424 // ENSGT00730000110941_0_Domain_5 (1436, 1509)

AMFML
LAKVQMKAKKIKE--AVRMFKKALELFSSSNKGPNVVAASVDCLHNLGLCYVEEGNLKMA
FDYFTRAVKTNPDFAEGFYQRGLCKVKLQKDSSILDFNRAIALNPKHFQ--AYLSRVAFY
GLKGRYSKAILNCNEAIRIYPQSVRAYLYRGVLKYYNK-NYKLAIKDLTTVVNMDKNSYV
AFYNRALCYTKIKELQMALIDFGIVLLLDARETITLNT

PF13181 // ENSGT00730000110941_0_Domain_12 (1659, 1688)

FINRGLIYTELEQYGLALEDFK
QAASISQTN--VILCQAAALC----HHRIHEFREAIDSFSQALKVNPLFLDAYIGRGNSY
MEFEHEEAIRQAQKDFLKALHLNPVCTKARISLCYNLQAQGKLQKAWNHFTITMEIDPQS
YLAYEGRAVVCLQMGINFAAMQDINAALKINTTAEFLTNRGVIHE

PF13432 // ENSGT00730000110941_0_Domain_17 (1846, 1901)

FMGQRQNAMKDYQAA
IAVDPKYSLAYFNAGNIYFHHRQFSQANDYYSKSLEFDPENEYVLM-NRAIINT---ILN
KYEEAKEDFACVIDRCPCWA

PF13181 // ENSGT00730000110941_0_Domain_20 (1941, 1973)

AVYLNRAYLYCCLKQYDLAEEDLSRALSLKPNDVVVYKLR
GEVRGKMGMTEEAIADYNQVLDLEECALVT

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--MEDISLMG-KIYVKIPQG-QAETPKIEAEQVSQMTDEE---PNRSVSEELPDDGSSIY
QIEQEGISDWPS-LDAEDIAFKFEESLETHPTEEPTIY--VEEGHHK-SDSKVPKQVSVK
VQSSEFLQIRGKEVKRTRRSKSE-TPPLRRKKSLKPQVDPKLLKKIPQVHPTPHLHHLCT
AAPAQQLPVELHLASRMCHTADKKGHSAPLGVFGPSFLGDYFADE--QRDRILYGIPVTD
ENQESVSVPPVPSRLPSETARKTRWRFHNPHLELLGQEMCAYPGFTKMFWNPAAPKFAVP
ESVMKETVYPQYERIQGSRILTKKFLSDSMENLIVYD---NRNLQSFLLRKCVSLENIQS
FHCQHSTQLKRAKSTVELSKEEAITPIEIKDDTQSNIKTMMFQRTKELEHQL--AKQNKA
EEPPTPVRESIDDILDN-----IQEEFSSKDLPLSLIEASKQAGITYIVYPKKK-KKWK-
KGLKSEKFTIVCEELSKPPNMI--TRSVSHGILPGQKKYFLRVPLYERLTRSPSLPNILN
FDKLVKRKGGMLEN------------SDPYMWVRDTLFKDKLQKTTTNVV--E--VTV--
------KRDLPESTEEPPKV--QLSDSLACDLPPEVIKHYESEVEILTEEINEKKTFPAF

PF13181 // ENSGT00730000110941_0_Domain_0 (1021, 1050)

AYCRRGAIYRKLGKLQSAMNDLQEAILLE

ENSGT00730000110941_0_Linker_0_1 (1050, 1096)

PLFLNAYWHRHFIYIFQDKMNEALDDLNYIS
KYNKNNADVYLSKAE

PF13414 // ENSGT00730000110941_0_Domain_1 (1096, 1133)

IYRRSNNITLTILNYSQAIKYRPTDADIYFRRGEVYE

ENSGT00730000110941_0_Linker_1_2 (1133, 1162)

KENRMLAV
DDFSKCIFYDPKRTDALLKRG

PF13432 // ENSGT00730000110941_0_Domain_2 (1162, 1220)

KFYFENENWISAIYDFTALLKIEPQNYEAWTYRGKAYFR
RRLYKQATEDFSIAIHLDPNNWVALYYRACIFRKSNPLRALQDYSVSALINDGYENLSCF
LHRGIVYAHLKLWLLAICDFETVISLERTSTLAYVNIGLIHMLHLDNYTEAIWHFSEAIR
VDPLYIQSYMCRAETY-YKLHRWKSAVNELSRAIHLQPDG-IQLYIIRGQYLLMMKCYDL
AKFTIYQVAEMNK---GLIGL--SPIQQAHIYSFCENHEKAIQVLDGMSWSRSEMTMFTL
LAKAQMKAKKIKE--AVRMFKKALEVFSNSNKGPNAVALSI

PF13181 // ENSGT00730000110941_0_Domain_7 (1482, 1513)

DCLHNLGLCYMVEGNLQMA
FDYFTKAVRANPDFAEGFYQRGLCKVKLQKDNSILDFNRAIALNPKHFQ--AYLSRVAFY
GLKGRYSKAILNCNEAIRIYPQSVRAYLYRGVLKYYNK-SYKLAITDLTTAINMDKNNYV
AFYNRAICYTKIKELHMALIDFGVVLLLDAGETVTLNTFINRGLIYTELEQYGFALEDFK
QAALLSQTN--VSLFQATAMC----HHRIQEFKEAINFFSQALTINPLFLDAYIGRGNSY
MEYEDEEAIKQAQKDFLKALHLNPLCTKARISLCYNLQALGKLQKAWNHFTITMEIDPQS
YLAYEGRAVVCLQMGINFAAMQDINAAIKINTT

PF13181 // ENSGT00730000110941_0_Domain_17 (1834, 1866)

AEFLTNRGVIHEFMGQRQNAMKDYQAA
IALDPKYSLAYFNAGNIYFHHRQFSQASDYYSKSLMFDPENEYVLM-NRAIINT---ILS
KYEDAKEDFAYVIDHCPFW

PF00515 // ENSGT00730000110941_0_Domain_20 (1940, 1973)

AAAYFNRAHLYCCLKQYELAEEDLSRALSLKPNDVLVYNLR
AEVRGKIGLTEEAMADYNQALDLEEYALVT

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------------------------------------------------------MMCYDL
AKFTIYQVAEMNK---GHIEL--SPIQQALIYSFCENHDKAIQVLDGIILNRPE

PF00515 // ENSGT00730000110941_0_Domain_6 (1435, 1470)

ITTYTL
LAKSQMKAKRSKE--AVRMFKKALDIFSHSDKGPNAVAASADCLYNLGLCYMDEGNLQMA
FDCFTKAVKANPDL

PF00515 // ENSGT00730000110941_0_Domain_8 (1515, 1548)

AEGFYQRGLCKVKLRKDSSILDFNRAITLDP-Y

ENSGT00730000110941_0_Linker_8_9 (1548, 1551)

YE-

PF00515 // ENSGT00730000110941_0_Domain_9 (1551, 1583)

-AYLSRVAFY
GLKGRYSKAILNCNEAIKIYPQSVRAYIYRGVLKYYNK-TYKLAITDLTTAINMDKNS

PF00515 // ENSGT00730000110941_0_Domain_11 (1619, 1652)

YV
AFYNRALCFTRIGELRMALTDYGIVLLLNAG

ENSGT00730000110941_0_Linker_11_12 (1652, 1656)

ETVT

PF00515 // ENSGT00730000110941_0_Domain_12 (1656, 1689)

LNTFINRGLIYEELEQYSFALEDFK
QAALISKTN--VGLCQATAMC----YYRNKEFEEAVNFFTWAININPCF

PF00515 // ENSGT00730000110941_0_Domain_15 (1730, 1766)

LDAYVGRGNSY
MEYGHDEATKQAQKDFLRALHFDPT

ENSGT00730000110941_0_Linker_15_16 (1766, 1767)

Y

PF00515 // ENSGT00730000110941_0_Domain_16 (1767, 1800)

IKARISLGYNLQAQEKFQKAWHHFTIAIEVDPKS
YLAYEGRAVVCLQMSDNFAAMQDINTAIKINTT

PF00515 // ENSGT00730000110941_0_Domain_17 (1834, 1867)

AEFLTNRGVIHEFMGQQQNAMKDYQAA
VSLNPTYSLAYFNAGNIYLHHRQFSQASDYFSKALKFDPENKCAMM-NRAIANT---ILK
KYEEAREDFANVVENCPFW

PF00515 // ENSGT00730000110941_0_Domain_20 (1940, 1973)

AAVYFNRAQLYCCLKQYELAEEDLSKALSLKPNDALVYNLR
AEVRGKLGVIEEAMADYNQALDLQDHSVIS

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-----------------------SPIQQAHIYLFCENHEKAIQVLDGMPWNRSE

PF13424 // ENSGT00730000110941_0_Domain_5 (1435, 1510)

MTTFTL
LAKAQMKAKKIKE--AVKIFKKILDFFANFDRGPNAVAITADCLHNLGLCYMEEGNWQTA
FDYFTKAVKANPELAEGFYQRGLCKVKLQKDNSILDFNRAIALNPKHFQ--AYLSRVAFY
GLKGRYSKAILNCNEAIKIYPQSVRAYLYRGVLKYYNK-NYKLAIRDLTTAINMDKNCYV
AFYNRALCYTKIRELQMALIDFGIVLLLDAGETITLNTFINRGLIYIELEQYGFALEDFK
QAALISQTD--VH

PF13181 // ENSGT00730000110941_0_Domain_14 (1694, 1727)

LCHATAMC----HHRIQEFKEAISFFTQALSINPLFLDAYIGRGNSY
MEYGHEEAIKQAQKDFLKALHLNPLCTKARISLCYNLQAQGKLQKAWNHFTITMDIDPQN
YLAYEGRAVVCLQKGINFAAMQDINAAIKINRTAEFLTNRGVIHEFM

PF13414 // ENSGT00730000110941_0_Domain_17 (1848, 1879)

GQQQNAMKDYQAA
IALDPKYWLAYFNAGNIYFHHRQFSQASDYYSKSLKFDPENEYVLM-NQAITNT---ILN
KYEEAKEDFACLIDRCPFWAAAYFNRAHLYCFLKQYHLAEEDLTTALSLTPNDVL

PF13181 // ENSGT00730000110941_0_Domain_21 (1976, 2004)

VYNLR
AEVRGKIGLTEEAMADYNQALDLEEYASVA

--------------------MSTIPRHFGLKYKEESYMFKELEKVRQETKKDFLRFKQKL
ASKPAVDASPVHSLYAPGAAR-------PARVSCAAAQT---SRGSPPAKGPAMSAAALL
QEVLGGAPCPSGLGEAAAPGKTWSFRPRDFYLRSSPFLRHQALKKPPVIASGFGTARPVV
LLPPPEPPMKRRACRVLGSSRHAAPRPVLDLGRGREESQEVAPLSGPCMAKERKVSS---
-VSAEDGYTDASSARRKVR----------IRTHFVSDSRAREAR-------EAAELGAQG
EQESWLPSDAREAAWQALLPARVIPTSIEEIIASLQSEAQLASDQTIKELIRSILGQNYD
IRMEDISLMG-KMYLKTSSMQ-AETPEIQAEHRFQMGAEE---SQTSMQKELPEAMSSIL
QIEQED-IEWGT-SEVESTVFKPQEISQVQPAEELSKP--LEDGQPT-SDSKEAKRVSLT
AKSSEFLQIEGKEVKQMQKRK-----SLRPRKSSKPLCDKKLREKIPRDYSMPHLHDLCT
TIPAQELPTDLRLASRVYHTANRKGHDTLLGKFGTSFLDDRFTDEE-QTDRILYGIPVMD
DNQECVHIPLTLQGIPPELAQGTRERAHKPHLQVLGEKMCAYPEFTKLFWNTAAPKFSVP
ESVMKKTLYPKYESVQASRLLTDKFSYKT----------------CFLPRKSASFENIQK
WFSAQSTQLRQVKSAVDLRKEDIIVPLEIKNDMQSSIKEVMFQKAKELKRQLQLTKQNKT
EEP-ISVKKKINDIFDN-----MCEKHSLRNLSLTLIEASKKAGISYIIE----------
----TTKLIFVYQELSKPPKSL--ERSTSHGILPEQKKYLFKVPLYERQIRCPSLPLYLN
FEKFFQTKGGIPENIDPRTWGGIPENIDPRTWAFDRLIAHKDVSTP-----VKE-----K
DDKISVPKDPPERVKEPPKL--KLSDDVESDLPQEVIKHYESEVKILTEEINDKTNYPAF

PF13181 // ENSGT00730000110941_0_Domain_0 (1021, 1050)

AYCRRGAIYRKLGKLQSAMNDLQRVMLLE

ENSGT00730000110941_0_Linker_0_1 (1050, 1088)

PLFLNAYWHRHLIYLFQDKINEALDDLNYIH
KYNKNNT

PF13181 // ENSGT00730000110941_0_Domain_1 (1088, 1119)

EAYLSKAEIYRGKKDITMAILNYTQAIKCRPTDADIYFRRGEMYEIANKVLAI
DDFSKCIFYDPKRTDALLKRGLFYYENENWFAAMEDFTALLNIDPQNSQARTYRGIAYVK
RKFYKEATQDFSAAIHFDPNNWLALYYRGCLFRESNPFRALQDYSVSALINDGYENLGCF
LHRGIVYAHLKLWLLAICDFEAVISLERTTTLAYVNIGLIHLLHLDNYTEAIWQFSEAIR
TDPLCIQSYLCRAETY-FKLHKLKKAVNELSRAIHLQPDG-IQLYIRRGQYLLMMKCYDL
AKFTIYQVAEMDK---GLIKL--SPIQQALIYSFCENHDKAVEVLDGISWNRPEMTMYAL
LAKVQMKAKRTKE--AVKMLKKALDVISHSDKGPNTTAIS

PF00515 // ENSGT00730000110941_0_Domain_7 (1481, 1514)

ADCLYNLGLCYMEEGNLQMA
FDSFTKAVKANPDFAESFYQRGLCKVKLHKDSSILDFNHAITLNPKHYQ--AYLSRVAFY
GLKGRYSKAILNCNKAIKIYPESVRAYLYRGVLKYHNK-TYKLAITDLTTAISMDKNSYI
AFYNRALCYTKIRELQMALADYGIVLLLDATETVKLNTFLNRGLIYVELDQYGFALEDFK
QAALISQTN--ESLCHATAMC----HHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSY
MECGHDEATKQAQKDFLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDIDPKN
YLAYEGRAVVCLQMGNNFAAMQDINAAMKINTTAEFLTNRGVIHEFMGHKQNAMKDYQDA
IYLNPKYS

PF07719 // ENSGT00730000110941_0_Domain_17 (1869, 1901)

LAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYILM-NRAITNT---ILK
KYKEAKEDFANVIESCPFW

PF00515 // ENSGT00730000110941_0_Domain_20 (1940, 1973)

AAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYKFR
AKVRCKIGLIEEAMADYNQALALEDHDSVI

--------------------MSTIPRHFGLKYKEESYMFKELEKVRQETKKDFLRFKQKL
ASKPAVDERPVHSLYAPGAAR-------PERVSRAAART---SRGSPLAKGPAMSAAALL
QEVLGGAPRPSGLGEAAAPGKTLSFRPRDFYLRSSAFLRHQTLKKPPVIASGFGTARPVV
LLPPPEPPVKRRACRVLGSSQHAAPRPVLDLGRGREESQEVAPLSGPCMAKERNVSS---
-VSTEDGYTDVSSGRRKVR----------IRTHFMSESRAREAR-------EAAGLGAQG
EQESLPPSDAREAAWQALLPARVIPTSIEEIIASLQSEAQLASDQTIKELIRSILGQNYD
IRMEDISLMG-KMYRKTSSMQ-AETPEIQAEHRFQMGAEE---SQTSMHKELPEAMSSIL
QTEQED-IEWGT-SEVESTVFKPQKISQVQPGEELSKP--LEDGQPT-SDSKEAKRVSLT
AKSSEFLQIEGKEVKQMQKRI-----SRRPRKSSKPLCDKQLREKIPRDYSMPHLHDLCT
TIPAQELPIDLRLASRVYHTANRKGHNTLLGKFGTSFLDDHFTDEE-QADRILYGIPVTD
DNQEYVHIPLTPQGIPPELAQGTREHVHKPHLQVLGEEMCAYPEFTKLFWNTAAPKFSVP
ESVMKETLYPKYESVQASRLLTDKFSYKSSAIT--FRQHSRTNFWYFLSRKSASFENIQK
WFGAQRTQLRQVKSAVDLRKEDIIAPLEIKNDMQSSIKEVMFQKTKELKRQLQLTKQNKT
EEP-IPVKKNIDDIFDN-----MCGKHSLRNLSLTLIEASKKAGISYIVYPKKKKMKWK-
KRLKQQKLIFVYQELSKPPKSL--ERSTSHGILPEQKKYLFKVPLYERQIRCPSLPLYLN
FEKFFQTGGGIPEN------------IDPRTWAFDRLIAYKDASTP-----VKE-----K
DDKISVPKDPPERVKEPPKL--KLSDDVESDLPQEVIKHYESEVKILTEEINDKTKYP

PF00515 // ENSGT00730000110941_0_Domain_0 (1019, 1050)

AF
AYCRRGAIYRKLGKLQSAMNDLQRVMLLEPLFLDAYWQRHLIYLFQDKINEALDDLNYIH
KYNKNNTEAYLSKAEIYRGKKDITMAILNYTQAIKCRPTDADIYFRRGEMYEIANKVLAI
DDFSKCIFYDPKRTDALLKRGLFYYENENWFAAIEDFTALLNIDHQNSQARTYRGIAYVK
RKFYKEATQDFSAAIHLDPNNWLALYYRGCLFRKSNPFRALQDYSVSALINDGYENLGCF
LHRGIVYAHLKLWLLAICDFETVISLERTTTLAYVNIGLIHLLYLDNYTEAIWQFSEAIR
IDPLCIQSYLCRAETY-FKLHKLKKAVNELSRAIHLQPDG-IELYIRRGQYLLMMKCYDL
AKFTIYQVAEMDK---GLIEL--SPIQQALIYSFCENHDKAIEVLEGISWNRAEMTMYAL
LAKVQMKAKRTKE--AVKMLKKALDVISHSDKGPNTTAIS

PF00515 // ENSGT00730000110941_0_Domain_7 (1481, 1514)

ADCLYNLGLCYMEEGNLQMA
FDSFTKAVKANPDFAESFYQRGLCKVKLHKDSSILDFNRAITLNPKHYQ--AYLSRVAFY
GLKGRYSKAILNCNKAIKIYPESVRAYLYRGVLKYYNK-TYKLAITDLTTAISMDKNSYI
AFYNRALCYTKIRELQMALTDYGIVLLLDATETVKLNTFLNRGLIYLELDQYGFALEDFK
QAALISQTN--ESLCHATAMC----HHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSY
MECGHAEATKQAQKDFLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDIDPKN
YLAYEGRAVVCLQMGNNFAAMQDINAAVKINTT

PF00515 // ENSGT00730000110941_0_Domain_17 (1834, 1867)

AEFLTNRGVIHEFMGHKQNAMKDYQDA
ISLNPKYSLAYFNAGNIYFHHRQFSQASGYFSKALKFDPENEYILM-NRAITNT---ILK
KYEEAKGDFANVIESCPFW

PF00515 // ENSGT00730000110941_0_Domain_20 (1940, 1973)

AAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFR
AKVRCKIGLIEEAMADYNQALHLEDHDSVI

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----------------------------------------------------MELKKYEL
ASLCIHQLAKMNE---VSFQI--QPAQQALIQSFCQNHSKAIECLHEAATTQPE

PF00515 // ENSGT00730000110941_0_Domain_6 (1435, 1470)

PSVFVL
LGKIQMKAEKTED--AVGSFKQAINLLMTSEKILPPTFEAAEMYYLMGLCYMEQINLLEA
CDAFSMAIRLHSSY

PF00515 // ENSGT00730000110941_0_Domain_8 (1515, 1547)

PDAFYQRGLCRMQLRQTKCIQDFNHTLELCPS

ENSGT00730000110941_0_Linker_8_9 (1547, 1548)

H

PF00515 // ENSGT00730000110941_0_Domain_9 (1548, 1583)

FQ--AYMGRAAYY
GSKGRYSKAIMNCNEAIKIHPN

ENSGT00730000110941_0_Linker_9_10 (1583, 1584)

S

PF00515 // ENSGT00730000110941_0_Domain_10 (1584, 1618)

VKAYFYRGILKYQNK-SFKAAIEDLSKTIVLDNTCIL
AYYNRAICYHQIKNFRKALKDYGIFLLHEENKEIV

PF00515 // ENSGT00730000110941_0_Domain_12 (1656, 1689)

LKVFINRGLLYMELGDYANACEDLK
EAVLLSPG

ENSGT00730000110941_0_Linker_12_14 (1689, 1692)

D--

PF00515 // ENSGT00730000110941_0_Domain_14 (1692, 1729)

SQIFQAIGTC----HYRLNEFEDAVRSFNQVLRLEPVSVEAYIGRGNSY
MKKGHEADLKQAQKDFLKAIHLNPMCMKARICLGYNLQTLGKLQSAWNQLTVVIAIDSKC
DAAYEGRASISLQMGEIFSALQDINAALKLTTTAPLLTNRGVINQLMGYLSCAMKDYQQA
ISVDPTYALAYFSAANIYFHNHQFSQAYCYYSEVLKLEPRN

PF00515 // ENSGT00730000110941_0_Domain_19 (1902, 1939)

ESAIM-NRAVTNT---ILK
NFEEAKEDFEKAVCLCPFSAAVYFNRANFYNALKQYELAEKDISTALSIQPND

PF00515 // ENSGT00730000110941_0_Domain_21 (1974, 2007)

AMMYRLR
ADIRAKLGFSREAVEDYKKAISIQEQTDDM

--------------------MSTIPRHFGLKYKEESYMFKELEKVRQETKKDFLRFKQKL
ASKPAVDERPVHSLYAPGAAR-------PERVSCAAART---SRGSPSAKGPAMSAAALL
QEVLGGAPRPSGLGEAAAPGKTLSFRPRDFYLRSSAFLRHQTLKKPPVIASGFGTARPVV
LLPPPEPPVKRRACRVLGSSRHAAPRPVLDLGRGREESQEVAPLSGPCMAKERKVSS---
-ISTEDGYTNVSSGRRKVR----------IRTHFMSESRAREAR-------EAAGLGAQG
EQESLPPSDAREAAWQALLPARVIPTSIEEIIASLQSEAQLASDQTIKELIRSILGQNYD
IRMEDISLMG-KMYCKTSSMQ-AETPEIQAEHRFQMGAEE---SQTSMHKELPEAMSSIL
QIEQED-IEWGT-SEVESTVFKPQEISQVQPAEELSKP--LEDGQPT-SDSKEAKRVSLT
AKSSEFLQIEGKEVKQMQKRI-----SLRPRKSSKPLCDKKLREKIPRDYSMPHLHDLCT
TIPAQELPIDLRLASRVYHTANRKGHNTLLGKFGTSFLDDHFTDEE-QADRILYGIPVMD
DNQEYVHIPLTPQGIPPELAQGTRERAHKPHLQVLGEEMCAYPEFTKLFWNTAAPKFSVP
ESVMKETLYPKYESVQASRLLTDKFSYKNSAIT--FRRHSRTNFWCFLSRKSASFENIQK
WFGAQPTQLRQVKSAVDLRKEDIIAPLEIKNDMQSSIKEVMFQKTKELKRQLQLTKQNKT
EEP-IPVEKNIDDILDN-----MCEKHSLRNLSLTLIEASKKAGISYIVYPKKKKMKWK-
KRLKQQKLIFVYQELSKPPKSL--ERSTSHGILPEQKKYLFKVPLYERQIRCPSLPLYLN
FEKFFQTKGGIPEN------------IDPRTWAFDRLIADKDASTP-----VKE-----K
DDKISVPKDPPERVKEPPKL--KLSDDVESDLPQEVIKHYESEVKILTEEINDKTKYPAF

PF13181 // ENSGT00730000110941_0_Domain_0 (1021, 1050)

AYCRRGAIYRKLGKLQSAMNDLQRVMLLEPLFLNAYWQRHLIYLFQDKINEALDDLNYIH
KYNKNNTEAYLSKAEIYRGKKDVTMAILNYTQAIKCRPTDADIYFRRGEMYEIANKVLAI
DDFSKCIFYDPKRTDALLKRGLFYYENENWFAAIEDFTALLNIDHQNSQARTYRGIAYVK
RKFYKEATQDFSAAIHLDPNNWLALYYRGCLFRKSNPFRALQDYSVSALINDGYENLGCF
LHRGIVYAHLKLWLLAICDFETVISLERTTTLAYVNIGLIHLLYLDNYTEAIWQFSEAIR
IDPLCIQSYLCRAETY-FKLHKLKKAVNELSRAIHLQPDG-IQLYIRRGQYLLMMKCYDL
AKFTIYQVAEMDK---GLIEL--SPIQQALIYSFCENHDKAIEVLEGINWNRAEMTMYAL
LAKVQMKAKRTKE--AVKMLKKALDVISHSDKGPNTTAIS

PF00515 // ENSGT00730000110941_0_Domain_7 (1481, 1514)

ADCLYNLGLCYMEEGNLQMA
FDSFTKAVKANPDFAESFYQRGLCKVKLHKDSSILDFNHAITLNPKHYQ--AYLSRVAFY
GLKGRYSKAILNCNKAIKIYPESIRAYLYRGVLKYYNK-TYKLAITDLTTAISMDKNSYI
AFYNRALCYTKIRELQMALTDYGIVLLLDATETVKLNTFLNRGLIYLELDQYGFALEDFK
QAALISQTN--ESLCHATAMC----HHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSY
MECGHAEATKQAQKDFLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDIDPKN
YLAYEGRAVVCLQMGNNFAAMQDINAAVKINTT

PF13181 // ENSGT00730000110941_0_Domain_17 (1834, 1866)

AEFLTNRGVIHEFMGHKQNAMKDYQDA
ISLNPKYSLAYFNAGNIYFHHRQFSQASGYFSKALKFDPENEYILM-NRAITNT---ILK
KYEEAKGDFANVIESCPFW

PF00515 // ENSGT00730000110941_0_Domain_20 (1940, 1973)

AAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFR
AKVRCKIGLIEEAMADYNQALHLEDHNSVI

--------------------MSTIPRHFGLKYKEESYMFKELEKVRQETKKDFLRFKQKL
ASKPAVDESPVHSLYVPGAAR-------PARVSCAAART---SRGSPPAKG---------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------AQE
EQESWPPSDAREAAWQALLPARVIPTSVEEIIASLQSEAQLASDQIITELIRSILGQNYD
IRMEDISLMG-KMYLKTSSMQ-AEAPEIQAEHRFQMGAEE---SQTSMHKELPEAMSSIL
QIEQED-IEWGT-SEVESTVFKPQEISQVQPAEELSKP--LEDGQPT-SDSKEAKRVSLT
AKSSEFLQIEGKEVKQMQKRK-----SPRPRKSSKPLCDKKLREKIPRDYSMPHLHDLCT
TIPAQELPTDLRLASRVYHTANRKGHDTLLGKFGTSFLDDRFTDEE-QTDRILYGIPVMD
DNQECVHIPLTPQRIPPELAQGTRERAHKPHLQVLGEKMCAYPEFTKLLWNTAAPKFSVP
ESVMKKTLYPKYESVQASRLLTDKFSYKSSAIT--LCRHSRTNFWCFLPRKSASFENIQK
WFSAQSTQLRQVKSAVDLRKEDIVAPLEIKNDMQSSIKEVMFQKAKELKRQLQLTKQNKT
EEP-ISVKKNTDDIFDN-----MCKKHSLRNLSLTLIEASKKAGISYIVYPKKKKMKWK-
KRLKQQKLIFVYQELSKPPKSL--ERSTSHGILPEQKKYLFKVPLYERQIRCPSLPLYLN
FEKFFQTKGGIPEN------------IDPRTWAFDSLIAYKDASTP-----VKE-----K
DDKISIPKDPPERVKEPPKL--KLSDDVESDLPQEVIKHYESEVKILTEEINDKTNYPAF

PF13181 // ENSGT00730000110941_0_Domain_0 (1021, 1050)

AYCRRGAIYRKLGKLQSAMNDLQRVMLLE

ENSGT00730000110941_0_Linker_0_1 (1050, 1088)

PLFLNAYWHRHLIYLFQDKINEALDDLNYIH
KYNKNNT

PF13181 // ENSGT00730000110941_0_Domain_1 (1088, 1119)

EAYLSKAEIYREKKDITMAILNYTQAIKCRPTDADIYFRRGEMYEIANKVLAI
DDFSKCILYDPKRTDALLKRGLFYYENENWFAAIEDFTALLNIDPQNSQARTYRGIAYVK
RKFYKEATQDFSAAIHLDPNNWLALYYRGCLFRKSNPFRALQDYSVSALINDGYENLGCF
LHRGIVYAHLKLWLLAICDFEAVISLERTTTLAYVNIGLIHLLHLDNYTEAIWQFSEAIR
IDPLCIQSYLCRAETY-FKLHKLKKAVNELSRAIHLQPDG-IQLYIRRGQYLLMMKCYDL
AKFTIYQVAEMDK---GLIEL--SPIQQALIYSFCENHDKAIEVLDGISWNRPEM

PF13424 // ENSGT00730000110941_0_Domain_5 (1436, 1510)

TMYAL
LAKVQMKAKRTKE--AVKMLKKALDVISRSDKGPNTTAISADCLYNLGLCYMEEGNLQMA
FDSFTKAVKANPDFAESFYQRGLCKVKLHKDSSILDFNRAITLNPKHYQ--AYLSRVAFY
GLKGRYSKAILNCNKAIKIYPESVRAYLYRGVLKYYNK-TYKLAITDLTTAISMDKNSYI
AFYNRALCYTKIRELQMALTDYGIVLLLDATETVKLNTFLNRGLIYAELDQYGFALEDFK
QAALISQTN--ESLCHATAMC----HHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSY
MECGHDEATKQAQKDFLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDIDPKN
YLAYEGRAVVCLQMGNNFAAMQDINAAMKINTT

PF13181 // ENSGT00730000110941_0_Domain_17 (1834, 1866)

AEFLTNRGVIHEFMGHKQNAMKDYQDA
ISLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYILM-NRAITNT---ILK
KYKEAKEDFANVIESYPFW

PF07719 // ENSGT00730000110941_0_Domain_20 (1940, 1973)

AAVYFNRAYFYYCLKQYELAEEDLNKALSLKPNDALVYKFR
AKVRCKMGLIEEAMADYNQALDLEDHDSVI

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-----------------SFEL--SPIQQSLVFSFCDNHKEAIKLLFSVTLSKPEPAMYML
LGKAQMKAKKIQX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX

PF00515 // ENSGT00730000110941_0_Domain_9 (1550, 1583)

XXAYISRAAYY
GMKGRYSKAILNCNEAIRIYPNSVRAFLYRGVLKFYNK-TYKLAITDLTIAVSMDKACFL
AFYNRAICYSKIKEFFMXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXDFR
EAVQINKND--

PF07719 // ENSGT00730000110941_0_Domain_14 (1692, 1729)

ANLFLAAGIC----HHRMGEFEEAVYSFTRVIELNPFFVDAYVGRGNSY
MEYGHKEADKQAQKEFIKALHFNPAYSKARISLGYNLQALGKFQKAWNHFTICMDIDLGN
CQAYEGRAVVCLQMGDNFAAIQDINAAVKISTS

PF07719 // ENSGT00730000110941_0_Domain_17 (1834, 1867)

AEFLTNRGVIHEFMGERHIAMKDYQTA
LTINPEYSLAYFNAGNIYLHHRQFSQ----------------------------------
------------------------------------------------------------
------------------------------

--------------------MSTIPKHFGLTAREESYMFKELEKIRQKTKKDYEQLRQRL
AAKPALNAVFEDQEKEERLGTAGGSREKKG-----HVSWAAKPSS--GAESGERPAAADL
Q--------GAPHSARGSPGKPQPFRPRDFYMRSSAFRRHPPYKEAPAIAPQVGTTRPVI
LLRPRSRRKRLREKGRGAPVTKRVSKGR----------APESPGLDVTHARYRL-ASS--
-LSSLSSDFDESGRLRRLR----------IRTHFQRDLVRWHH--------KPSSRSRRE
G------SSASQGTA-PLLGIRYLPKNIEEIIASLQSEAQQASDQTIKELIQSILGQNYD
IAMEDISLME-QMYLRPSQVQ-LEVPKEVEEKNFPPSITEHS-VVPSIYEELPETLSSIF
QVEQEEAMKWVA-IDENSSAFKSQETLDTVPPEDTRKP--LDSALPT-ADVKLTSQPALK
VEPRGFMQIRGRELKPTYKSRPKKLPKPR--ISV-KPEDRKLIKKIPQAHLPSHLHDLCT
RVPTMELPVDLCLASRVYHTPDRKGHKAVLGLLGLPLSGDHCVDE--QRERLIYGVPLMS
EKQKYTGVTSVPAKKFPEPEQTNKWEASKANLQLSGEEVSAYPGISKMFWNLSAPKFALP
ESTIRATLYPKYESVQTSRLLTEKLS-VTKETEIIVNTSTKRSFKNLIIKKSASYENIQK
YSSAPYTRLKRSKSEVELRKEETPLPFIMKDDIDTNLEQLRYQKKKELEHRL--AKQRSL
LNLSRK------DSLES-----AQGSEDMKCLSVSLIEASRKAGITYIVFPSKKKKLLK-
KGMKFHKTAHVYEKLSRPPKKI--KRSASHGVLPGERKYFLKVPLYERQIRCPSVPTLLN
FDKFAESRGGIPKN------------TDPWTWVLELFAKDKPRKTHTPPVA----SSV--
------QEDVPEPVIELSKL--ELSDHVKSNLPPEVIKYYESEVEKLTQEIKSEKRNLAF

PF13181 // ENSGT00730000110941_0_Domain_0 (1021, 1046)

AYCRRGAIYRKLGKLQSAMNDLQEA

ENSGT00730000110941_0_Linker_0_1 (1046, 1095)

IFQEPLFLNAYWHRHFIYLFQDKVNDALDDLNFIN
KYNKNHAEAYLSKA

PF13414 // ENSGT00730000110941_0_Domain_1 (1095, 1132)

EIFREKKDVTLAILNYSQAIKCRPKDADLYFKRGEMYETTNKVLAI
DDYSKCIYYNRKRSDALWKRGMFYFENGNWIGAVYDFTSLLKLNPYNSDARTYRGRAYFK
RNLYKQATQDFSAAIHLDPNNWLALYYRACLFRKSSPYRALQDYSVSVLINDGYDNLNCF
LHRGVLYTQLKLWMLAICDFETVVSLERNATLAYINIGIIYLEHLDNYTEAFWWFTEAIK
VDPLYLQSYICRAETY-SKLHKLKRAVIELTRAIHLQPDA-IHLYIMRGQFLLMMKSYDL
AKFTIYQVAEMNK---GVIEM--SPIQEALIYSFCENHDKAIHILEGVIASKPDISTYAL
LAKAQMKAKRIKE--SVRLFKKALELYTFSDKGPVATSVS

PF00515 // ENSGT00730000110941_0_Domain_7 (1481, 1514)

AECLYNLGLCYMEEGNFQMA
FESFTKAVKANPEFAEAFYHRGLCKVKLNKQNSILDFNRALILNPKHYQ--AYLSRVAYY
GLKGRYSKAILNCNEAIKLYPESVRAYICRGVLKYYNR-TYKLGITDLSTAIKMDKNNYT
AYYNRALCYTKIGEHQMALRDYGIVLLLDAGENIALNTVINRGLIYTELKQYGFALEDFK
QAALMSKTS--VSLCQATATC----HHRIKEFEGAVEFFTRAIKINPRYVDAYIGRGNSY
MEYSQEDAMIQAQKDFLKALHLDPSCLKARISLGYNLQAQGKFQKAWIHFTVGIESNPKS
YLAYEGRAVVCLQMSNYFAAMQDINCAIKINST

PF13181 // ENSGT00730000110941_0_Domain_17 (1834, 1866)

AEFLTNRGVIHEFMGQQQSAMADYQAA
ISLNPSYSLAYFNAGNIYLHHRQFSQASDYFSTALKFNPENEYALM-NRAVTNS---VLK
KYEEAEKDFSCAMERCPHWAALYFNRASFYVYLKKYKLAEEDLGIGLSLKPDEAMMYNLR
AQVRGKMGLIAEAMSDYNQALDLEECSTAM

--------------------MSAVPRHFGLKHTEESYMFKEREKVRQETKKDFLRFKQKL
AAKPAADGGP--------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------EIVASLQSEAQLASDQTIRELIQSVLGQNYD
IETEDISLMG-KIYVRTSQMQ-VKTPQIPEEQRLQIKVEE---PQKSILKELPETVSSIL
QIELED-VEWGA-SEAESTVFKPQEILEIQPAEELSKP--SEDGQPT-SDSKAAKWATLK
VKSSEFLQIKGKEVKRMQKSRSG-ISSLRPRKSLKPPQDLKLHKKIPQDSSIPRLHGLCT
TIPIRELPIDLCLASRVYHTPDKKGHTALLGIFGASFLDDCFTDEE-QRDRILYGIPVMN
DNQDYVHAPSTPPRILPELARGTTQHAHKPQLRVLGEEVCAYPEFTKLFWNTAAPKFSVP
ESVMKETLYPKYES--------------------------------FLLRKSASYENIKK
CFNVQLPQLKKVKSLVELRKKETIVPLEIKDDMQNSIKEVMFQKARELKRQ--LAKQNKT
EEF-IYEKKNIEVIFDN-----IHEKHSLKDLSFSLIEASRKAGISYIVYPKGKTMKWK-
KRLKQQKLAEVYNELSKPPKSL--KRSTSHGILPEQKKYLLKVPLYERQIRCPSLPTCLN
FETFIQSEGGIPEN------------SDPRTWALEICTKHKVQSAP-----IPEK----K
VDKMSLLEDLPEKLQEPPKL--ELSDCLESELPLEIVKYFESQVEILTEEINNTKKYPAF

PF13181 // ENSGT00730000110941_0_Domain_0 (1021, 1046)

AYCRRGAIYRKLGKLQSAMNDLQEAIFLEPLFLNAYWHRHFIYLFQDKISEALDDLNYIL
KYNKNHAEAYLSKAEIFRERKEITLAILNYSQAIKCKPIDADIYFRRGEMNEIANKVLAI
DDFSKCIFYDPKRTDALLKRGLFYFENKSWLAAIQDFTSLLNIDHQNSQARTYRGRAYFK
RNFHKQATQDFSAAVHLDPSNWVAFYYRACSFRKSNPFRALQDYSVSALINDSYENLYCF
LHRGILYAHLKLWMLAICDFETVISLERTVTLAYINIGLIHLLYLDNYTEAIWQFSEAIR
IDPLCIQSYICRAEAY-YKSHKLKKAVNELSRAIHLQPDG-IQLYIIRGQYLLMMKCYDL
AKFTIYQVAEINK---GLIEL--NSIQQALIYSFCENHDKAIQVLEAITWNRPE

PF13181 // ENSGT00730000110941_0_Domain_6 (1435, 1466)

ATMYVV
LAKAQMKAKRIKE--AVRMFKKALD

ENSGT00730000110941_0_Linker_6_7 (1466, 1481)

IFSHSDKGSNATALS

PF00515 // ENSGT00730000110941_0_Domain_7 (1481, 1514)

ADCHHNLGLCYMEEGNVQMA
LDSFTKAVKANPNFAEGFYQRGLCKAKLHKDNSILDFNHAITLDPKHYQ--AYLSRVAFY
GLKGRYSKAILNCNQAIKIYPESVRAYLYRGVLKYYNK-TYKLAITDLTTAINMDKKCYI
AFYNRALCYTKIRELQMALTDYGIVLLLDAGETITLNTFINRGLIYTELEQYGFALE---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------

--------------------MSSIPKHFGLKPREESYIFKELEKVRRETKKEFLLLKQHL
ASRLSLDESPAEKAARAH-------------------SG---------------------
--------------ARLRPLPR--------------------------------------
------------A------------------------------------THHRLSSSS--
-SVSVVVGEDSSGQPRRVR----------IHTHFLRQDT------------RPDPRATRD
SGKA--------SPP-APLLTRAVPTCIEEIIASLQSEAQLASDQTIKELIGSVLGQHYD
ITVEDISLMQ-QMYLRPSQMQ-LETPQMEAEPGLQINV--------TMHDELPEDVSSVF
QDEQEDMLEWKA-SEVESVVFKSEDIPGVQLEDDLIKP--LEDGYPK-SDLKTFKRPSVK
VESSEFLKIRGKEVKQTQKCIPVILP-PRQKKPLKPIQDEKLIKKIPQAPPIPHHHDLCT
TVPADELPVELRLASRMCHTLDKKGHCYMLGQFRPSFLGDCSMEEQRDRCEILYGVPVKS
PTEDYANAPPFSPEKPPEQA-------RKPCLPLLGEEISAYPGFTKLFWNLTAPKFAVP
ESVMRETLYPKYESAQTSKILTEKFLSERKESEVVLESN-GKSFKPFILRKSASYENIPE
YSSAKYKKLKRPRSTVELRKKETTPQFVVKDDTLSNIKDLQFQKEKEQARLL--TKQKQP
DAPSWK----------------GSDKDSLTYLSMSLIEASRKAGISYIVYPRKRKKKWK-
KGF--AKIKLVYEKLSKPPRRL--KRSTSHGILPGEKKCLLKVPLYEIQERCPSVPVLLN
FDKFVQSKGGIPGN------------TDPRTWAFKTFTKGKQQKAPTKPDTLF--V----
------QNNLLEKATELPKL--ELSDSLKCTLPREIMEHYQSEVERLTEEINNKKTHL

PF00515 // ENSGT00730000110941_0_Domain_0 (1019, 1050)

AF
AYCRRGAIYRKLGKLQSALDDLQKAIFLEPLFLNAYWHRHFIYLYQDKINEALDDLNYIH
KYNKNNAEAYLSKAEIFREKKDFMLAILNYTQAIKCRPTDADIYFRRGEMYEKTNRVLAM
DDYAKCIFYSPQRKDALMKRGVF

PF13432 // ENSGT00730000110941_0_Domain_2 (1164, 1220)

YFENENWIASIQDFTALIKVDPQNSQARMYRGRAYSK
RNLYRQAIQDLSASIHLDPNNWLAFYYRACLFRKNDPHRALQDYSVSALINDGYENFSCF
LHRGLVYAHLKLWWLAICDFETVISLERTVILAYINIGLIYLLYLDNYTEAFWKFSDAIK
IDPLYIQSYICRAETY-HKMHSLKRAVNELSRAIHLQPDG-LQLYIIRGQYLLSMKSYEL
AKFTIYQIAEMNK---GLIEL--SPIQQALIYSFCENHEKAIQVLDGVTSNRPEFM

PF13181 // ENSGT00730000110941_0_Domain_6 (1437, 1466)

VYAL
LAKVQMKAKKVKE--AVKIFKKALE

ENSGT00730000110941_0_Linker_6_7 (1466, 1481)

MFSSSDKGSLATFIS

PF13181 // ENSGT00730000110941_0_Domain_7 (1481, 1513)

ADCLYNLGLCYMEEGNLQMA
FDSFTKSVKANPEFAEAFYQRGLCKVKLQKDNSVIDFNRAITINPKHYQ--AYLSRVAYY
GLKGRFSKAILNCNEAIRIYPEGLRAYLYRGVLKYYNK-CYKLAVIDLTTAVNMNKNSYI
AFYNRAMCYTKIRELQKALMDFGTVLLLDPGETVMLNTFINRGLIYNELGQYGFALEDFK
QGALISQTN--VSHFQATAIC----HHRINEFEEAVDFFTRAIKINSCFLDAYIGRGNSY
MEYENNRATKLAQKDFVKALHLNPTSSKARISLGYNLQAQGKFQKAWTHFTIAVEVDPKS
YLAFEGRSVVCLQMSNHFAAMQDMNTALKINTTAEFLTNRGVIHEFM

PF13414 // ENSGT00730000110941_0_Domain_17 (1848, 1879)

GQQQNAMKDYQAA
ISLDPTYSLAYFNAGNIYFHHRQFSQARDYFSKAFTFDPENDYALM-NRAVANT---ILE
KYEEAKQDFSCAVEHCPHW

PF00515 // ENSGT00730000110941_0_Domain_20 (1940, 1973)

AAIYFNRAYLYYCLKQYELAEEDLSKALSLKPSDPVVYSLR
AEVRGRVGRIKEAMSDYNQTLDLEE-----

--------------------MSTIPKHFGLKYKEESYMFKELEKVRQETKKDFLRFKQKL
ASKPGVGEGRVHSPYAPGPAH-------PARLSRAAART---PRGSAPAKGPARSAAALL
QEVLGGAPRPSGLGEAAAPGKTRPFLSRDFDFRSSAFLRHLPQKKPPVIASGFGTARPVV
LLPPPEPPAKRRG---LQSPRPAGPRRVLDLARGREESQAAAPLAGAGE---GKASS---
-VSAGDGSAEAGGGRRRVR----------IRTCFVSESRAREAP-------GAAGLRARG
ERESWPPCDAREAAWQALPPARVVPTSIEEIIASLQSEAQLASDQTIKELIRSVLGQNYD
IRMEDISLMG-KTYLKTSSMQ-AESPQIQAEHGFQMGAEE---SQMSMRKELPEAISSIF
QIEQED-VEWGP-LEVESTVFKPQETLQVQPAEELSKP--LEHGQPT-SDSKEAKPMSLK
AKSSEFLQIKGKQIKRIRKRK-----SLRPRKSSKPLCDKKLHKKIPRDYSTPHLHNLCT
TVPARQLPVDLCLASRVYHTASRKGHNTLLGLFGTSFLDDRFTDEE-QTERILYGIPVMD
DNQEYVHVPPTLQGIPPELAQGTRERAHKPHLQVLGEEMCAYPEFTKLFWNTAAPKFSVP
ESVIKETLYPKYESVQASRLLTEKLSPETSVLT--LHQYSRTNFNCFLLRKSASLESVQK
CFSAQPTQLRRAKSSVDLRKEEIIAPLEIKNDMQSSIKEVVFQKANELKRQLQLLKQNKT
EHP-IPVKESIDDIFEN-----ICEKHSLKNLSLSLIEASKKAGISYIVYPKKKKIKWK-
KRLKQRKLTFVYEELAKPPKSL--ERSESHGILPEQKKYLFKVPLYERQIRCPSLPLYLN
FEKFVQMKGGIPEN------------SDPRTWALDMLIEHKYQRTP-----IKE-----K
VDKISVLEDPPEIVIEPPKL--KLNDDVESSLPPEVIKHYESEVKILTEEINNKTEYPAF

PF13181 // ENSGT00730000110941_0_Domain_0 (1021, 1050)

AYCRRGAIYRKLGKLQSAMNDLQKAMLLEPLFLNAYWHRHLIYLFQDKINEALDDLNYIH
KYNKNNTEAYLSKAEIYRGKKDVTLAILNYTQAIKCRPTDADIYFRRGEMYEIANKVLAI
DDFSKCIFYDPKRTDALLKRGLFYYENENWFAAIEDFTALLNIDHQNSQARTYRGIAYVK
RKFYKQATQDFSAAIHLDPNNWLALYYRGCLFRKSNPFRALQDYSVSALINDGYENLGCF
LHRGIVYAHLKLWLLAICDFETVISLERTITLAYINIGLIQLLHLDNYAEAIWQFSEAIK
VDPLCIQSYICRAETY-FKLHKLKKAVNELSRAIHLQPDG-IQLYIRRGQYLLMMRCYNL
AKFTIYQVAEMDK---GLIEL--SPIQQALIYSFCENHDKAIEVLDGISWNRNDMTMYAL
LAKVQMKAKRTKE--AVRTLKKALDVISHSDKGPNATAIS

PF00515 // ENSGT00730000110941_0_Domain_7 (1481, 1514)

ADCLYNLGLCYMEEGNLQMA
FDSFTKAVKANPDFAESFYQRGLCKAKLHKDSSILDFNCAITLNPKHYQ--AYLSRVAFY
GLKGRYSKAILNCNMAIKIYPESVRAYLYRGVLKYYNK-AYKLAITDLTTAINMDKNSYI
AFYNRALCYTKIRELRMALTDYSIVLLLDATETVKLNTFINRGLIYIELGQYGFALEDFK
QAALISQTN--GSLYHATAMC----HHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSY
MEYGLDEATKKAQKDFLKALHINPGYIKARICLGYNLQIQGKFQKAWNHFTIAMDIDPKN
YLAYEGRAVVCLQMGNNFAAMQDINAAMKINTT

PF13181 // ENSGT00730000110941_0_Domain_17 (1834, 1866)

AEFLTNRGVIHEFMGHKQNAMKDYQEA
ISLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLM-NRAIANT---ILK
KYEEAKEDFANVIERCPFW

PF00515 // ENSGT00730000110941_0_Domain_20 (1940, 1973)

AAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFR
AKVRGKIGLSEEAMADYNQALDLEDYAPVT

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-----------------------------------------------------EMKEYKL
ASFCIYQVAEMGE---VSFKT--SPVQQALVQSFCQNHNEAIACLQELIANQPTPSIFVL
LGKIQMKAKKTKD--AVESFREALKILNSSAKKLPNTIEAAEIYYLMALCYMDQVSLLQA
YKAFSLAVKVYPNFPDAFYQRGLCRMQLKQARCIQDFNRALAINPKHFQ-

PF00515 // ENSGT00730000110941_0_Domain_9 (1551, 1582)

-AYLSRAAYY
GSKGRYSKAILNCNEAIKIHPDSVRAYLYRGTLKYHNK-TYKNAIDDLTKTIDLDKICIL

PF00515 // ENSGT00730000110941_0_Domain_11 (1621, 1642)

AYYNRAICYHQIKDFKKALKDYGILLLLESSKEIVLAVLINRALLYVELEDYSNALEDFK
EASLSDPRN--S

PF00515 // ENSGT00730000110941_0_Domain_14 (1693, 1728)

EIYQAIGIC----CHRLEQFEEAVNSFTQGLKLDPFFLDAYVARGNSY
MEYGHETGNTKAQKDFLKAMHLNPKCVKARICLGYNLQAFGKFQKAWNQFTVAIDIDPKC
HVAYDGRAVVCLQMGDTFAAFQDINAALKLTTSAQLLTNRGVINQFMGHLNCSMKDYQQA
ISINPGY

PF00515 // ENSGT00730000110941_0_Domain_17 (1868, 1901)

ALAYFNAANIYFHHRQFAQASSYYSKALQLDPRNESAVL-NRAITNT---LLQ
KIEEAKEDFEKAICLCPFS

PF07719 // ENSGT00730000110941_0_Domain_20 (1940, 1973)

AAVYFNRANLYRTLKQYELAEKDISTALSIQPNDALMYKLR
ADVRGKMGFSEEAIADYKQAISIQEMIDAM

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-----------------------------------------------------AMRQFDL
AKFTIYQVAEMNK---GLIEL--SPVQQALIYSFCENHDKAIQVLHAITLSKPE

PF00515 // ENSGT00730000110941_0_Domain_6 (1435, 1470)

ITVYAL
LAKAQMKAKRNKE--AVRTFKKALDVFAHSDKGPNAVVASADCLYHLGLCYMEEGSLQTA
FDSFTKAVKTNPDF

PF00515 // ENSGT00730000110941_0_Domain_8 (1515, 1547)

AEGFYQRGLCKVKLRRDNSILDFNRAITLNPK

ENSGT00730000110941_0_Linker_8_9 (1547, 1548)

H

PF00515 // ENSGT00730000110941_0_Domain_9 (1548, 1583)

YQ--AYLSRVAYY
GLKGRYSKAILNCNEAIKIYPESVRAYLYRGVLKYYNK-AYKLAIRDLTIAINMDKNS

PF00515 // ENSGT00730000110941_0_Domain_11 (1619, 1652)

YV
AFYNRAICYTKINELQMALTDYGVVLLLDAG

ENSGT00730000110941_0_Linker_11_12 (1652, 1656)

ETVT

PF00515 // ENSGT00730000110941_0_Domain_12 (1656, 1689)

LNTYINRGRIYAELEQHGFALEDFK
QAAVISQTN--VSLCHATAMC----HHRIKEFEDAVNFFTWALKINSSF

PF00515 // ENSGT00730000110941_0_Domain_15 (1730, 1766)

VDAYVGRGNAY
MEYGHEEATRQAQKDFLRALHLNPI

ENSGT00730000110941_0_Linker_15_16 (1766, 1777)

YTKARISFSYN

PF00515 // ENSGT00730000110941_0_Domain_16 (1777, 1800)

LQAQGKFQKAWNHFTIALEIDPKS
YIAYEGRAVVCLQMSNNFAAIQDINAAIKINTT

PF00515 // ENSGT00730000110941_0_Domain_17 (1834, 1867)

AEFLTNRGVIHEFMGQQQNAMKDYQAA
ISLNPMYSLAYFNAGNIYFHHRQFSQAWDYFSKALQYDPEDECALM-NRAVTNT---ILK
KYEEAKEDFANVVDSCPFW

PF07719 // ENSGT00730000110941_0_Domain_20 (1940, 1973)

AAVYFNRANFYCCLKQYEIAEADLSKALSLKPNDAVAYKLR
AEVRGKIGLIEEAMADYNQALDLQEFASVV

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-----------------------------------------------------MMKCYDL
AKFTIYQVAEMNK---GLIEL--SPIQQALIYSFCENHDKAIQVLDSVTLNRPELTMYIL
LAKAQMKAKRNKE--AVRMFKKALDIFSHSDKGPNAVAAS

PF00515 // ENSGT00730000110941_0_Domain_7 (1481, 1514)

ADCLYNLGLCYMEEGNIQMA
FDCFTKAVKANPDFAEGFYQRGLCKVKLHKDSSVLDFNRAITLNPKHYQ--AYLSRVAFY
GLKGRYSKAILNCNEAIKIYPQSVRAYIYRGVLKYYNK-TYKLAITDLTTAINMDKNSYV
AFYNRALCYTKINELRMALIDYGIVLLLDAGETVTLNTFINRGLIYVELQQYSFALEDFK
QAALISKTN--VSLCQAT

PF00515 // ENSGT00730000110941_0_Domain_14 (1699, 1727)

AMC----YHRNKEFEEAVDFFTWALKINPCFLDAYVGRGNSY
MEYGHEKATKQAQKDFLKALHINPTYINARISLGYNLQAQGKFQKAWNHFTIAIEVDPKC
YLAYEGRAVVCLQMGDNFAAIQDINDAIKINTT

PF00515 // ENSGT00730000110941_0_Domain_17 (1834, 1867)

AEFLTNRGVIHEFMGQKQNAMRDYQAA
ISLNPTYSLAYFNAGNIYFHHRQFSQASDYFSKALRFDPENEYATM-NRAIANT---ILE
RYKEAKEDFAHVVESCPFW

PF00515 // ENSGT00730000110941_0_Domain_20 (1940, 1973)

AAVYFNRAHFYCCLKQYELAEEDLSQALSLTPDDALVYKLR
AEVRGKIGLTEEAVADYIQALNLQEYASGI

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------------------------------------------------------MKCYDL
AKFTIYQVAEMNKDKYSLIGL--SPIQQAHIYSFCENHDKAIQVLDGMSWNRSEMTMFTL
LAKAQMKAKKIKE--AVRMFKKALEVFSHSDKGPNAVAISVDCLHNLGLCYMEEGNLQM-
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---------------------------------------NYKLAIRDLTIAVNMDKSSYA
AFYNRALCYTKIRELQMALIDFGIVLLLDAGETITLNTFINRGLIYTKLEQYGFALEDFK
QAASISQTD--VSLCQASAMC----HHRIQEFKEATDFFTQALKINPLFLDAYTGQGNSY
MGYGHEA-TKQAQKDFLKALHLNPLCTKARISLCYNLQAQGKLQKAWKHFTITMEIDPNS
YLAYEGRAVVCLQMGINFAAMQDINAAIKINTTAEFLTNRGVIHEFMGQQQSVMKDYQAA
IALDPKYS

PF07719 // ENSGT00730000110941_0_Domain_17 (1869, 1901)

LAYFNAGNIYFHHRQFSQASDYYSKSLKFDPENEYVLM-NRAITNT---ILN
KYEEAKEDFAYVIERCPFWAAVYFNRAHLYCCLKQYDLAEEDLSRALSLKPNDVL

PF13181 // ENSGT00730000110941_0_Domain_21 (1976, 2004)

VCNLR
AEVRGKMGLIEEAMADYNQALDLEEYASVT

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--------------------------------------MEADIYFRRGEMYEIANKVLAI
DDFSKCIFYDPKRTDALLKRGMFYYENENWILAIQDFTAILNIDPQ

PF13414 // ENSGT00730000110941_0_Domain_2 (1187, 1245)

NSQARTYRGRAYFK
RQFYKQATQDFSVAIHLDPNNWLALYYRGCLFRKSSPFRALQDY

ENSGT00730000110941_0_Linker_2_4 (1245, 1328)

SVSALINDGYENLSCF
LHRGILYTDLKLWLLAICDFETVISLERTVILAYINIGLIHLLYLDNYFEATWHFSEAIR
LDPLYIQ

PF07719 // ENSGT00730000110941_0_Domain_4 (1328, 1359)

SYICRAETY-QKLHKLKKAVRELSRAIHLQPDG-IQLYIIRGQYLLMMKCYNL
AKFTIYQVAEMNK---GLIEL--SPIQQALIYSFCENHDKAIQVLDRITLNRPELTMYTL
LAKAQMKAKRNKE--AVRMFKKALDIFSHSDKGPNAIAA

PF13414 // ENSGT00730000110941_0_Domain_7 (1480, 1545)

SADCLYNLGLCYMEEGNIQMA
FDCFTKAVKANPGFAEGFYQRGLCKVKLQKDSSILDFNHAITLN

ENSGT00730000110941_0_Linker_7_9 (1545, 1560)

PKHYQ--AYLSRVAF

PF00515 // ENSGT00730000110941_0_Domain_9 (1560, 1582)

Y
GLKGRYSKAILNCNEAIKIYP

ENSGT00730000110941_0_Linker_9_10 (1582, 1586)

QSVR

PF13414 // ENSGT00730000110941_0_Domain_10 (1586, 1649)

AYIYRGVLKYYNK-TYKLAITDLTTAINMDKNSYV
AFYNRALCYTKINELRLALTDYGIVLLL

ENSGT00730000110941_0_Linker_10_12 (1649, 1658)

DAGETVMLN

PF00515 // ENSGT00730000110941_0_Domain_12 (1658, 1684)

TFINRGLIYVELEQYSFALEDFK
QAA

ENSGT00730000110941_0_Linker_12_15 (1684, 1698)

LISKTN--VNLCQA

PF13414 // ENSGT00730000110941_0_Domain_15 (1698, 1764)

TAMC----HHRNKEFEEAVDFFTWAIKINPCFLDAYVGRGNSY
MEYGHDKAAKQAQKDFLKALHID

ENSGT00730000110941_0_Linker_15_16 (1764, 1772)

PTYIKARI

PF13414 // ENSGT00730000110941_0_Domain_16 (1772, 1831)

SLGYNLQAQGKFQKAWNHFTIAIEVDPKC
YLAYEGRAVVCLQMGDNFAAIQDINAAIKI

ENSGT00730000110941_0_Linker_16_17 (1831, 1834)

NTT

PF00515 // ENSGT00730000110941_0_Domain_17 (1834, 1867)

AEFLTNRGVIHEFMGQQQNAMKDYQAA
ISLNPTYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPQNECATM-NRAIANT---ILK
KYKEAKEDFAYVVESCPFW

PF13414 // ENSGT00730000110941_0_Domain_20 (1940, 2004)

AAVYFNRAHFYCCLKQYELAEEDLSKALSLKPDDALIYNLR
AEVRGKIGLTEEAVSDYIQALDLQEYSSVI

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-----------------------------------------------------MMKCYEL
AKFTIYQVAEMDK---GLLEL--SPVQKALIYSFCENHEKALQVLDGTTLSRPDITMYAL
LAKAQMKAKRIKE--AMKIFKKALDAFSHSDKGPNATAIS

PF07719 // ENSGT00730000110941_0_Domain_7 (1481, 1513)

ADCLYHLGLCYMEEGNLQMA
IDSFTKAVKANPELAECFYQRGLCKVKLHKDNSILDFNRAITLNPKHYQ--AYLSRVAFY
GSKGRYSKAILSCNEAIRIYPGSVRAYLYRGVLKYYNK-TYKLAIRDLSTAIKMDKKSYA
AFYNRALCYTKIKELQLALTDYGVVLLLDAGETITLNT

PF00515 // ENSGT00730000110941_0_Domain_12 (1659, 1687)

FVNRGIIYAELEQYGFALEDFK
EAILMNQT---VSLYQGAAMC----HHRIREFEEAIHCFTCAIKIKPRYLDAYNGRGNSY
MKYGDSEFIKKAQKDFLKAIHFDPSYIKARISLGYSLQAQGKFQKAWRHFTIATEIDPKS
YLAYEGRAIICLQMGNNFAAMKDINTAMKINTKPEFLTNRGVIHEFMGQQQNAMRDYQAA
ILLNPKYP

PF07719 // ENSGT00730000110941_0_Domain_17 (1869, 1901)

LAYFNAGNIYFHHRQFSQASDYFSKSLKFDPGNKYAVM-NRAVANT---LLK
RYEEAKEDFAYVIECCPSW

PF00515 // ENSGT00730000110941_0_Domain_20 (1940, 1973)

AAAYFNRAQLFCFLKQYELAEKDLSKALSLIPNDAVAYNFR
AKVRGKIGMIEEAVADYNQALDLEEYASVT

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-------------TDALLKRGTFYYENENWISAIQDFTALLNIDPQN

PF07719 // ENSGT00730000110941_0_Domain_2 (1188, 1221)

SQARTYRGRAYFK
RQFYKQATQDFSAAIHLDPN

ENSGT00730000110941_0_Linker_2_4 (1221, 1326)

NWLALYYRACLFRKSSPFRALRDYSVSALINDGYENLGCF
LHRGILYADLKLWLLAICDFETVISLERTVILAYINIGLIHLLYLDNYFEATWHFSEAIR
LDPLY

PF00515 // ENSGT00730000110941_0_Domain_4 (1326, 1360)

IQSYICRAETY-QKLHKLKKAVRELSRAIHLQPD

ENSGT00730000110941_0_Linker_4_6 (1360, 1435)

G-IQLYIIRGQYLLMMKCYDL
AKFTIYQVAEMNK---GLIEL--SPIQQALIYSFCKNHDKAIQVLDGITVNRPE

PF00515 // ENSGT00730000110941_0_Domain_6 (1435, 1470)

LTMYTL
LAKAQMKAKRNKE--AVRMFKKALDIFSH

ENSGT00730000110941_0_Linker_6_7 (1470, 1481)

SDKGPNAIQAS

PF07719 // ENSGT00730000110941_0_Domain_7 (1481, 1514)

ADCLYNLGLCYMEEGNVQMA
FDCFTKAVKANPEFAEGFYQRGLCKVKLHKDSSVLDFNRAITLNPKH

PF00515 // ENSGT00730000110941_0_Domain_9 (1548, 1583)

YQ--AYLSRVAFY
GLKGRYSKAILNCNEAIKIYPQSVRAYIYRGVLKHYNK-TYQLAITDLTTAINMDKNS

PF00515 // ENSGT00730000110941_0_Domain_11 (1619, 1652)

YV
AFYNRALCYTKINELRMALMDYGIVLLLDAG

ENSGT00730000110941_0_Linker_11_12 (1652, 1656)

ETVT

PF00515 // ENSGT00730000110941_0_Domain_12 (1656, 1689)

LNTFINRGLIYVELEQHSFALEDFK
QAALISKT

ENSGT00730000110941_0_Linker_12_14 (1689, 1692)

N--

PF00515 // ENSGT00730000110941_0_Domain_14 (1692, 1729)

VSLCQATAMC----HHRNKEFEEAVDFFTWALKINPCFLDAYVGRGNSY
MEYGHEKATEQAQKDFLKALHINPTY

PF00515 // ENSGT00730000110941_0_Domain_16 (1767, 1800)

MKARISLGYNLQAQGKFQKAWNHFTIAIEVDPKC
YLAYEGRAVVCLQMGDNFAAIQDINAAIKINTTAEFLTNRGVIHQFMGQQQNAMKDYQAA
ISLNPTY

PF07719 // ENSGT00730000110941_0_Domain_17 (1868, 1901)

SLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENECATM-NRAIANT---ILK
KYKEAKEDFACVAESCPFW

PF00515 // ENSGT00730000110941_0_Domain_20 (1940, 1973)

AAVYFNRAHFHCCLKQYELAEEDLSKALSLKPDDALVYKLR
AEVRGKIGLVGEAVADYVQALNLQEYASVV

--------------------MSMIPKHFGLKTREESYMFKELEKLRQETKKDFLRSRQKL
ESKPILDEGPIRLLQAPGWGR-------PADKKRDSSPRPGGLQASPSPRGPGASEAALE
PETHACTARPWGLGHAAARPKPRAFRPREFYLRSSAFRRYP-LQKPPVIAARVGTSKPLV
LLPPPAPPVRPRALPEAGSPRPSASRQGLELARAHEVTEEVARPAETRRAKARKTSS---
-LSSEDSDLGPGGRWKQLM----------VTTHFVRRLSVGEAG-------EAAGSVLRA
QRPSRLSSEAQDAAWLSLPPRRAPPKSFKEVLTSLQSEAQQASDQIIKELIQSILGPNYD
FKMEDMTLMG-KAHLKTPQTQ-AEILHTQAEQGLERVVEE---SQMGVLKELPEATSSIF
QMEQGNVSEWGE-SEAESIVFKSPEMSEVQVAEKTSRP--LEDEQPT-KDSKVGKQLSLK
EKSSKLLHITGKGVKRMRKSNLG-IPPLRPGKSLKFLRAQNLPKKIPHDYCTPHLHDLCT
TIPAQELPVDLRLASRLYHTADKKGHDMLWEIFGFPFLDDHFTEEE-QRNRILYGIPVMG
ENQEYASIPSTAPGIFPELPQTAGEHAQKPYLQVLGEEVPAYPGISKLLWSPAAPKFSVP
ESVMKKTLYPKYESVQASQILTVKFSSESKESI--IVGHSESICRFLSLRKSASFGDIKK
SSRVPSVQLKRVKSAVELRKEETAVPLEIKDDMQSNIKEVMFQKAKEWE--FLLTKQSKT
EQS-KPAKESIDVLLDN-----IQEKHAVRDLSVSLIEASRKAGISYIVYPRKTKMKLK-
KRLRSDKLTIVYEELSKPPKTI--QRSASHGTLPGQKKYFIRLPLYERPIRSPSLPSCLN
FDNFVQSMGGIPEN------------SDPRTWALDMFFKYELWKEP-----K-------E
VVETSVLKDLPKTMKESKKL--ELSDSLKCDLPPGVIEHYESEVQILTEEINSKKTFPVF

PF00515 // ENSGT00730000110941_0_Domain_0 (1021, 1050)

AYCRRGAIYRKLGKLKSAMNDLQKVITLEPLFLNAYWHRHFIYLFQDKINEALDDLNYIS
KYNKNNAEVYLSKAEIFRKQKDAALAILNYSQAIKCRPTDADIYFRRGEMYEKQNRALAI
DDFSKCIFYDPQRTDALFKRGMFYYENENWILATQDFTALLNIDHQHSKARTYRGRAYVK
QRYYKQATQDLSAAIHLDPNNWLALYYRACLFRKSNPLRALQDYSVSVLINDGYENLSSF
LHRGIIYTNLKFWMLAICDFETVISLERTIILPYINIGLIHLLHLDNYTEAIWQFSEAIR
IDPLYIQSYICRAEAF-HKVNKLKKAVNELSRAIHLQPDG-IQLYIIRGQYLLMMKCYEL
AKFTIYQVSEMNR---GLIDL--TPIQQALIYSFCENHDKAIQVSEGITWNRPDMATFAL
IAKAHMKAKRTKE--AVRRFKEAVDAFSLSDQGPNAVSLL

PF00515 // ENSGT00730000110941_0_Domain_7 (1481, 1514)

ADCLYNLGLCYTEEGNIQMA
FDYFTRAVKVNPDFAESFYQRGLCKVKLHKDNSILDFNRAITLNPKHYQ--AYLSRVAYY
GLKGRYSKAILNCNEAIKVCQKNVRAYLYRGVLKYYNK-SYKLAIRDLTTAINMDKRNYV
SFYNRALCYTKIGENQTALTDYGIVLLLDPGETITLNTFINRGRIYAELEQYGFAVEDFK
QAVLMTQNN--VSLCQAAAVC----HHRIEEFEEAVNFFTQALKINPRFLDAYLGRGSSY
MEYGQEEPNKQAQKDFTTALHFNPAYTKARISLGYNLQAQGKFQKAWNHFTIALEVDPKS
YLAYEGRAVVCLQMGNNFAAMQDINVAIKINTTAEYLTNRGVIHELMGQKQNAMKDYQAA
ISLNPAYSL

PF00515 // ENSGT00730000110941_0_Domain_17 (1870, 1901)

AYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYARM-NRAVAHM---LLK
KYEEAKDDFARVIDSCPLW

PF00515 // ENSGT00730000110941_0_Domain_20 (1940, 1973)

AAAYFNRAHLHCCLKQYELAEVDLSKALSLKPNDALVYNLR
AEVRGKIGLIDEAVGDYNRALDLEEYASVK

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-----------------------------------------------------MMKNYEL
AKFTIYQVAEMNR---GLIDL--TPIQQALIYSFCENHEKAIQVLEGLTWSRPDIVLFAV
IAKAHMKARRTKX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX

PF00515 // ENSGT00730000110941_0_Domain_7 (1500, 1514)

A
FEYFTKAVKVNPD

ENSGT00730000110941_0_Linker_7_8 (1514, 1515)

F

PF00515 // ENSGT00730000110941_0_Domain_8 (1515, 1547)

AESFYQRGLCKAKLRKENSILDFNRAITLNPK

ENSGT00730000110941_0_Linker_8_9 (1547, 1548)

H

PF00515 // ENSGT00730000110941_0_Domain_9 (1548, 1583)

YQ--AYLSRVAYY
GLKGRYSKAILNCNEAIKICPKNVRAYLYRGVLKYYNK-TYKLAIRDLTIVINMDKRN

PF00515 // ENSGT00730000110941_0_Domain_11 (1619, 1652)

YI
SFYNRAICYTKIGELQMALTDYGVVLLLDPGETITLNTFINRGCIYVELGQHCFAVEXXX
XXXXXXXXX--XXXX----XXXXXXXXXI

PF00515 // ENSGT00730000110941_0_Domain_14 (1710, 1729)

EEFEEAVNFFTEALKINPHSLDAYIGRGNSY
MEYDEEERTKQAQKDFVTVLHFNPAY

PF00515 // ENSGT00730000110941_0_Domain_16 (1767, 1800)

TKARISLAYNLQAQGKFQKAWNHFTIALEADPKS
YLAYEGRAVVCLQMGNNFAAMQDINVAIKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXX

PF00515 // ENSGT00730000110941_0_Domain_18 (1887, 1901)

ARDYFSKALKFDPE

ENSGT00730000110941_0_Linker_18_19 (1901, 1902)

N

PF00515 // ENSGT00730000110941_0_Domain_19 (1902, 1939)

EYARM-NRAVAHT---LLK
NYEGAKEDFAHVIDSCPS

ENSGT00730000110941_0_Linker_19_20 (1939, 1940)

W

PF07719 // ENSGT00730000110941_0_Domain_20 (1940, 1973)

AAVYFNRAHLYCCLKQYELAEVDLNKALSLKPRDALIYNLR
AEVRGKIDLIEEAVADYNLALDLEEGASVK

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----------MDT---GLIEL--SPVQQALIYSFCENHDKAIEVLERLTWNKPEISMFAL
LAKANMKAKRTKE--AVKIFKKTLDIFSYSDKGPSATAIS

PF00515 // ENSGT00730000110941_0_Domain_7 (1481, 1514)

ADCLYNLGLCYMEEGNLQLA
FDSFTKAVKANPD

ENSGT00730000110941_0_Linker_7_9 (1514, 1537)

FAEVFYQRGLCKVKLSKDNSILD

PF13432 // ENSGT00730000110941_0_Domain_9 (1537, 1583)

FNRAITLDPRHYQ--AYLSRAAFY
GLKGRYSKAILNCNEAIKIYPGSVRGYLYRGVLKYYNR-TYKLAITDLTTAINMNKKCYV
AFYNRALCYTKIKEFQMALIDYGIVLLLDAGETITLNTFINRGLIYSELEQYGFALEDFK
QAALVSQTN--VNLCQAVAVC----HHRIKEFEEAIKFFTWAIEINPCFLDAYIGRGNSY
MEYGHGEATNRAQKDFLKALHFNPSYIKSRIC

PF13432 // ENSGT00730000110941_0_Domain_16 (1773, 1814)

LGYILQDQGKFQKAWRHFTIATEVDPKS
YLAYEGRAMVCLQMGNNFAAMQDMNTAMKINTTAEFLTNRGVIHEFMGQRQNAMKDYQAA
ISLNPKYS

PF00515 // ENSGT00730000110941_0_Domain_17 (1869, 1901)

LAYFNAGNIYFHHRQFSQASDYFSKALKFDPEDKYALM-NRAVANT---ILK
KYEEAKEDFAYAVESCPFWAAVYFNRAQLYCCLKQYELAEEDLSKALSLVPNDGV

PF13181 // ENSGT00730000110941_0_Domain_21 (1976, 2004)

VYNLR
AKVRGKIGRIEEAMADYNQALDLEEYASVT

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-----------------------------------------------------MMKCYDL
AKFTIYQIAEMDK---GLIEL--SPMQQALIYSFCENHDKAIEVLDGISWNRAEMTVCAV
LAKVQMKAKRTKE--AVKMLKKVLDAISHFDKGPNATAIS

PF07719 // ENSGT00730000110941_0_Domain_7 (1481, 1513)

ADCLYNLGLCYMEEGNLQMA
FDSFTKAVKANPDFAESFYQRGLCKVKLHKDSSILDFNRAITLNPKHYQ--AYLSRVAFY
GLKGRYSKAILNCNKAIKIYPESVRAYLYRGVLKYYNK-TYKLAITDLTTAISMDKNSYI
AFYNRALCYTKIRELQMALTDYGIVLLLDATETVKLNTFLNRGLIYVELDQYGFALEDFK
QAALISQTN--GSLCHATAMC----HHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSY
MEYGHDEATKQAQKDFLKALHINPAYMKARISFGYNLQAQGKFQKAWNHFTIAIDIDPKN
YLAYEGRAVVCLQMGNNFAAMQDINAAMKINTTAEFLTNRGVIHEFMGHKQNAMKDYQDA
ISLNPKYS

PF07719 // ENSGT00730000110941_0_Domain_17 (1869, 1901)

LAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLM-NRAITNT---ILK
KYEEAKEDFANVIESCPLW

PF07719 // ENSGT00730000110941_0_Domain_20 (1940, 1973)

AAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFR
AKVRGKIGLIEEAMADYNQALDLEDYASVI

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------------M---DKEDT--HPIQQALIYSFCENHDKAIQVLDRITLNRPELT

PF13181 // ENSGT00730000110941_0_Domain_6 (1437, 1466)

MYTL
LAKAQMKAKKIKE--AMRMFKKALD

ENSGT00730000110941_0_Linker_6_7 (1466, 1481)

IFSHSDKGPNAVAAS

PF00515 // ENSGT00730000110941_0_Domain_7 (1481, 1514)

ADCLYNLGLCYMEEGNIQMA
FDCFTKAVKANPDFAEGFYQRGLCKVKLNKDSSVLDFNRAITLNPKHYQ--AYLSRVAFY
GLKGRYSKAILNCNEAIKIYPQSVRAYIYRGVLKYYNK-TYKLAITDLTTAINMDKNSYI
AFYNRALCYTKISELRMALTDYGIVLLLDAGETVMLNTFINRGLIYVELEQYTFALEDFK
QAALISKTN--VSLCQATAMC----HHRYGEFEEAVDFFTWALKIDPCFLDAYVGRGNSY
MEYGHAEATKQAQKDFLKVLRINPTYTKARISLGYNLQAQGKFQKAWNHFTVAIEVDPKC
YLAYEGRAVVSLQMGDNFAAIQDINAAIKINTTAEFLTNRGVIHEFMGQQQNAMKDYQAA
ISLNPTYS

PF00515 // ENSGT00730000110941_0_Domain_17 (1869, 1901)

LAYFNAGNIYFHHRQFSQASDYFSKALKFDPENECAAM-NRAIANT---ILK
KYKEAKEDFAYVVESCPFWAAVYFNRAHFYCCLKQYELAEGDLSRALSLKPDDALIYNRR
AEVRGRIGLIEEAVADYIQALDLQEYSPVM

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-----------------------------------------------------EMKKYSL
ASFCINYAAEMTQ---AYLEPGSSAAQQALVQSFRQQYSNAIECLVSAIQAKPA

PF00515 // ENSGT00730000110941_0_Domain_6 (1435, 1470)

PALVIL
LGKIQMKANNSKD--AVKTFRDALDMFKSSNDLILSPSNKAEILFNLGLCYMEQFDFQKA
LEALTSAIKVRSRF

PF00515 // ENSGT00730000110941_0_Domain_8 (1515, 1547)

HEAYYQRGLCRMHLQQAKCLDDFNKALEINPN

ENSGT00730000110941_0_Linker_8_9 (1547, 1548)

Y

PF00515 // ENSGT00730000110941_0_Domain_9 (1548, 1583)

FQ--ALLCRATFY
GFRKRYSKAIMNCNAAIKVQPHSVRAYLYRGALKYYIK-VRRIL------SLIAKKSS

PF00515 // ENSGT00730000110941_0_Domain_11 (1619, 1652)

YV
CAYLRGVCHHQTKMYDEALKDYSIVLLLGGW

ENSGT00730000110941_0_Linker_11_12 (1652, 1656)

KEVD

PF00515 // ENSGT00730000110941_0_Domain_12 (1656, 1689)

SKVLVNRGLLYLELQDFANALEDFK
CVALRTPGD--IKIHLVIGNC----HQRLQQYEEAVQAFNQALNITPLS

PF00515 // ENSGT00730000110941_0_Domain_15 (1730, 1766)

AEACIGRGNAY
IEYGHQRGTAQAKRDFLRALHLSPS

ENSGT00730000110941_0_Linker_15_16 (1766, 1767)

C

PF00515 // ENSGT00730000110941_0_Domain_16 (1767, 1800)

VAARICLGYTLQAQGLFQQAWNHFTVALDIDPQS
ILGFEGRAIVSLQIGDTFAALQDMNAALKLCGSAQLLTNRGVIHQFMGKLPNAMRDYQAA
ITADQDYSLAYFNAANLYLHNRQFTQAKEYYTRAVALDPAN

PF00515 // ENSGT00730000110941_0_Domain_19 (1902, 1939)

ESAVL-NRGITNM---LLQ
DAQAALHDFQLVLSLCPV

ENSGT00730000110941_0_Linker_19_20 (1939, 1940)

S

PF00515 // ENSGT00730000110941_0_Domain_20 (1940, 1973)

SAAYFNRASLYNTLQQYQWAESDISQALNLQPDDPLIYKLR
ADIRGKLGLTKEAIEDYEHAITL-------

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-----------------------------------------------------TMRCYDL
AKFTIYPVAEMNK---GLIEL--SPVQQALIYSFCEKHDKAIQVLNAISLSKPE

PF00515 // ENSGT00730000110941_0_Domain_6 (1435, 1470)

ITTYAL
LAKAQMKAKRNKE--AVRTFKKALDVFSH

ENSGT00730000110941_0_Linker_6_7 (1470, 1481)

SDKGPNITVAS

PF00515 // ENSGT00730000110941_0_Domain_7 (1481, 1498)

ADCLYNMGLCYVEDGNLQMX
XXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXX

PF00515 // ENSGT00730000110941_0_Domain_9 (1550, 1583)

XXAYLSRVAYY
GLKGRYSKAILNCNEAIKIYPE

ENSGT00730000110941_0_Linker_9_10 (1583, 1584)

S

PF00515 // ENSGT00730000110941_0_Domain_10 (1584, 1618)

ARAFLYRGVLKYYNK-TYNLAITDLTTAINLDKNSYI
AFYNRAICYTKIKELQMXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXDFK
QAALISQT---

PF00515 // ENSGT00730000110941_0_Domain_14 (1692, 1729)

VSLCQAVALC----HHRIKEFEEAVNFFTWALKINPRFLDAYVGRGNSY
MEYGHDAATKQAQKDFLKALHFNPMY

PF00515 // ENSGT00730000110941_0_Domain_16 (1767, 1800)

TKARISLGYNLQAQGKFQKAWNHFTITIAIDPKS
YEAYEGRAVVCLQMSNNFAAIQDINAAIKINTT

PF07719 // ENSGT00730000110941_0_Domain_17 (1834, 1867)

AELLTNRGVIHEFMGQKQNAMKDYQAA
ISLNPKYALAYFNAGNIYFHHRQFSQ----------------------------------
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------------------------------

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------------------------------------------------------MKKFEL
ASFCIHQVAEMDK---GFFEC--SLVQEALVQSFCQNHNKAIECAQAAAKKQPEPPMFVL
LGKIQMKAKKHKD--AVVSFKQALKLLTGSAKSPPNTFEAAEMFFLIGECYMEQVCLIEA
CEAFTSAVKLYPRYADAYYQRGLCRMYLQRAKSILDFNKTLAVAPNHFQ-

PF00515 // ENSGT00730000110941_0_Domain_9 (1551, 1582)

-AYLSRAAYY
GSKGRFSKAIANCTEAIKIQPKSVRAYLYRGTLKCYNK-TYKQAVQDLTTSIDLDNTCML

PF00515 // ENSGT00730000110941_0_Domain_11 (1621, 1643)

AYYNRAISYHLLKDYKNALKDYGIVLLLEANKDIVLKVVINRGLLYTELDQYMAALEDFT
EAMLSKPRD--SQLF

PF00515 // ENSGT00730000110941_0_Domain_14 (1696, 1727)

KVIGQC----YHRLQKYEEAVQSFSEVLKIDPFSVDGYIGRGNAY
MEYGHIEGTQQAQKDFLKAIHMYPISVKARLCLGYNLQALGKFQKAWAQFTAAILIDPKC
HIAYDGRAIVCLQMSDTFAAFQDTNAALKIITSAELLTNRGVINQFMGYLNCAMNDYQQA
ITVDPNY

PF07719 // ENSGT00730000110941_0_Domain_17 (1868, 1901)

ALAYFNAANIYFLNRQFVQANNYYSKALTLDPKNESAFL-NRAITNT---LLK
KFEEAKADFENAICLSPFS

PF00515 // ENSGT00730000110941_0_Domain_20 (1940, 1972)

AAIYFNKANLHKTLQQYEQAEEDISKALSIQPYDSLMYKLR
ADIRGKMGLIKEAIADYRKAISIQELISTG

--------------------MSSVPKHFGLTAREELYMFKELEKIRHQFKKESPEFKQKS
AARSALGANSEDDLEDFEDQD-----------EESPQPSAQRKPSSSRAQSPGRPAAADL
Q--------GAPPSTRRGPVKPRPFCPRDFYLRSSAFLRYSLCAEPPAIGPQAGTARPVV
LLQPRSRLPKPHVKIRGEPV----SRRVFVVSPAQEA-----RGLEVVRPRYRL-ASS--
-LSSLGSEADESGRLQRLR----------IHTHFLRESMGASR--------WLRPGSRGS
REGG----STGQATW-PLPVTRFIPTSIEEIIASLQSEAQLASDQTIKELIQSILGQNYD
LSMESISFME-QMYLRPSLIQ---TPKQEEEKESQTTI------KQSIYEELPEAVSSIF
QIEQEDLLEWGA-LGEENLEFKSQEMLEIVPVEDSSKP--LEAGRPT-TDRKTRKRSPLK
VKPSDFLQIRGKEVKRVQKSRPIFKP-LKTRKFVRHHQDKKLIKKIPQAHPFPNLHDLCT
TTPALELPVDLRLASRVYHTADRTGHKPMVGLLGSSVLGNCCIDE--QRDRILYGVPVTS
EKQ------------FLESMQTSQWQAHNPNLKLSGEEVSAYPGASKMFWNLTAPKFSVP
ESFMRETLYPKYESVQTSRILTEKLS-ESKESVVILNTYTRRSFKSLIIKKSASYENIKK
YSSAPYSRLKRSKSTVELRKEGSPPPIVVKDDIDSNLKQLLYQKRKEMERQL--ARQMGV
LETSLK------GSIET-----LQESDSMKYLSVSLVEASRKAGISYIVYPRKKKKLWK-
KGLRFQKLPLVYEQLSKPPKKL--ERSTSHGILPGQKKSSLKVPVYEVQIRSPSVPAVLN
FDHFAQSKGGIPEN------------TDPRTWVLETFAKDKPQKTPAPV------AHV--
------EKETPEPVPDLPKL--ELSDQIQCNLPPEVIKYYESEVERLTQEIKSEKKIPVF
AYCRRGAIYRKLGKLQSAMNDLQETIFVEPLFLNAYWHRHFIYLFQDKINDALDDLNFIN
KYNKNNAEAYLSKA

PF13414 // ENSGT00730000110941_0_Domain_1 (1095, 1132)

EIFREKKDITLAILNYSQAIKCRPKDADLYFKRGELY

ENSGT00730000110941_0_Linker_1_2 (1132, 1159)

ETTNRVLAI
DDFSKCILYDPKRTDALM

PF13432 // ENSGT00730000110941_0_Domain_2 (1159, 1221)

KRAMYYFENENWIAAIHDYTALLKLEPQNSQARTDRGRAYFK
RSLYKQAIQDFSIAIHLDPNNWLALYYRACLFRKASPHRALQDYSTSVLINDGYDNLNCF
LHRGILYADLKLWMLAIYDFETVISLERTAISAYINIGLIYLLHLDNYTEAFWRFSEAIR
VDPLYIQSYIYCQRTSPIKVFKAHR-------IITYSMLRIKAVISSRGQYLLMMKCYDL
AKFTIYQVAEMNK---GLIEL--TPVQQALIYSFCENHDKAIQVLEGVTVSRPEIYTFAL
LAKAQMKAKKIKE--SVRMFKKALDMFSSSDKGPSATNVS

PF07719 // ENSGT00730000110941_0_Domain_7 (1481, 1513)

AECLYSLGLCYMEEGNLQMA
YDSFTKAVKANPEFAEAFYHRGLCKVKLNKDNSILDFNRAITLNPRHYQ--AYLSRVAYY
GLKGRYSKAILNCNEAIRLYPESVRAYICRGVLKYYNR-SYKLAITDLTTAVSMDKNSYT
AFYNRALCYTKIKELDMALRDYGIVLLLDAGERIALNTFINRGLIYTELKEYGFALEDYK
QAALISQTS--VSLCQATAMC----HHRIKEFEGAVDFFTRAVKINPCFLDAYIGRGNSY
MEYGQDEALKLAEKDFLRALHLDPASSKARISLGYNLQAQGKFQKAWNHFTIATEADPKS
YLAYEGRAVVCLQMSNNFAAMQDINSAIKINTTAEFLTNRGVIHEFMGQKQNAMTDYGAF
SQAMCI-------SFNIFFYTGPVNTDFNF----LTFGPF--------------------
----------SLPVQFPGWGSVFFITLRLP------------------------------
------------------------------

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------------------------------------------------------MKCYDL
AKFTIYQVAEMNKDKYSLIGL--SPIQQAHIYSFCENHDKAIQVLDGMSWNRSEMTMFTL
LAKAQMKAKKIKE--AVRMFKKALEVFSHSDKGPNAVAISVDCLHNLGLCYMEEGNLQM-
------------------------------------------------------------
---------------------------------------NYKLAIRDLTIAVNMDKSSYA
AFYNRALCYTKIRELQMALIDFGIVLLLDAGETITLNTFINRGLIYTKLEQYGFALEDFK
QAASISQTD--VSLCQASAMC----HHRIQEFKEATDFFTQALKINPLFLDAYTGQRNSY
MGYGHEA-TKQAQKDFLKALHLNPLCTKARISLCYNLQAQGKLQKAWKHFTITMEIDPNS
YLAYEGRAVVCLQMGINFAAMQDINAAIKINTTAEFLTNRGVIHEFMGQQQSVMKDYQAA
IALDPKYS

PF07719 // ENSGT00730000110941_0_Domain_17 (1869, 1901)

LAYFNAGNIYFHHRQFSQASDYYSKSLKFDPENEYVLM-NRAITNT---ILN
KYEEAKEDFAYVIERCPFWAAVYFNRAHLYCCLKQYDLAEEDLSRALSLKPNDVL

PF13181 // ENSGT00730000110941_0_Domain_21 (1976, 2004)

VCNLR
AEVRGKMGLIEEAMADYNQALDLEEYASVT

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----------------------------------------------------MELKKYEL
ASLCIHQLAEIDE---ESFKS--QPVQQALIQSFCQNHNKAIESLRKATATQPE

PF00515 // ENSGT00730000110941_0_Domain_6 (1435, 1470)

PSMFVL
LGKIQMKAEKTKD--AVKSFKQAIELQMT

ENSGT00730000110941_0_Linker_6_7 (1470, 1481)

SAKILHNAFEV

PF00515 // ENSGT00730000110941_0_Domain_7 (1481, 1514)

AEMYYLMGLCYMEQTNLLQA
RDAFNMAIRLHSRYPDAFYQRGLCRMQLGQAKCIRDFNRTLALCPSH

PF00515 // ENSGT00730000110941_0_Domain_9 (1548, 1583)

FQ--AYMSRAAYY
GSKGRYSKAIMNCNEAIKILPN

ENSGT00730000110941_0_Linker_9_10 (1583, 1584)

S

PF00515 // ENSGT00730000110941_0_Domain_10 (1584, 1618)

ARAYFYRGTLKYQNK-TFKAAIEDLSKTIDLNKTCML
AYYNRAICYHQIKNFRQALKDYGILILHELSKEII

PF00515 // ENSGT00730000110941_0_Domain_12 (1656, 1689)

FKVLINRGLLYMEVSDYANACEDFK
EAALLSPG

ENSGT00730000110941_0_Linker_12_14 (1689, 1692)

DLS

PF00515 // ENSGT00730000110941_0_Domain_14 (1692, 1729)

SKIFQAIGIC----YHRLNEFEEAVRSFNQVIKLEPLSVDAYIGRGNSY
MESGHEAGLKLAQKDFVKAIHLNPMCTKARICLGYNLQVHGKLQRAWNQFTVAIVIDPKC
YAAYDGRASVCLQMGENFAAFQDINAALKLTTTAPLLTNRGVINQLMGYLSCAMKDYQQA
ISVDANY

PF00515 // ENSGT00730000110941_0_Domain_17 (1868, 1901)

ALAYFSAANIYFHNHQFSQAYCYYSKVLKLEPRNESAIM-NRAITNT---ILK
NFEEAREDFEKAVCLCPFSAAVYFNRANFYNGLKQYEQAEKDISTALSIQPND

PF00515 // ENSGT00730000110941_0_Domain_21 (1974, 2007)

ALMYRLR
ADIRAKLGFNKEAVEDYKQAISIQEQIDCV

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-------------------------------------Q-TYKLAIKDLNIAIAMNKACFL
AFYNRAICYNKIKEFHLALKDYGIVLLLNVGDDIK

PF00515 // ENSGT00730000110941_0_Domain_12 (1656, 1689)

AKTLINRGLIYTELKMIANALEDFK
EAVQINKDD--ANLFQAAGIC----HHRMGEFEEAVCSFTRVIELNPFFVDAYVGRGNSY
MEYGHEVADKQAQKDFIKALHFNPAYSKTRISLGYNLQAQGKFQKAWNHFTICMDIDPGN
CLAYEGRGIVCLQMGDNFAAIQDINSALKITISAEFLTNRGVIHEFMGERHIAMKDYQAA
LSISPEYS

PF07719 // ENSGT00730000110941_0_Domain_17 (1869, 1900)

LAYFNAGNIYLHHRQFSQASDFYSKALQFDPLNDSAVL-NRAITNI---ILQ
KFEEAKQDFIKAIHLCPFWAAVYYNKAHLYYCLQQYETAEEDLSKALSLQPNDHL

PF00515 // ENSGT00730000110941_0_Domain_21 (1976, 2004)

AYKLR
ADVHGKMGMMEEALKDYNQSLDLQEFAKV-

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-----------------------------------------------------KMKRFDL
AKFTIYQVEEMNK---GLIEL--SPVQQALIYSFCENHDKAIQVLQAVTMSKPD

PF00515 // ENSGT00730000110941_0_Domain_6 (1435, 1470)

ITMYAL
LGKAQMKAKRNKE--AVRTFKRALDVFVH

ENSGT00730000110941_0_Linker_6_7 (1470, 1481)

PDKGQSAMVAS

PF00515 // ENSGT00730000110941_0_Domain_7 (1481, 1514)

ADCLYHLGLCYMEEGNLQMA
LDAFTKAVKTNPDFAEGFYQRGLCKAKLRNDSSILDFNRAVTLNPNH

PF00515 // ENSGT00730000110941_0_Domain_9 (1548, 1583)

YQ--AYLSRVAYY
GLKGRYSKAILNCNEAIRIYPDSMRAYLYRGVLKFYNK-AYNLAIRDLTVAIXXXXXXXX
XXXXXXXXXXXXXXXXXALIDYGVVLLLDAGEAVV

PF00515 // ENSGT00730000110941_0_Domain_12 (1656, 1689)

LNTFINRGLIYSELEQYGFALEDFK
QATVMNPT

ENSGT00730000110941_0_Linker_12_14 (1689, 1692)

N--

PF00515 // ENSGT00730000110941_0_Domain_14 (1692, 1729)

VNLCHASATC----HHRIKEFEDAVYFFTWALKINSSFVDAYVGRGNSY
MEYGHEEAIKQAQKDFLRALHLNPIY

PF00515 // ENSGT00730000110941_0_Domain_16 (1767, 1800)

TKARVSLGYNLQAQGKFQKTGNHFTIALEIDPKS
HXXXXXXXXXXXXXXXXXXXXXXXXXXXXINTTAEFLTNRGVIHEFMGQQQNAMRDYQAA
ISLNPQY

PF00515 // ENSGT00730000110941_0_Domain_17 (1868, 1901)

ALAYFNAGNIYFHHRQFLQACDYFSKALQFDPEDEGALM-NRAITNT---ILE
KYEEAKEDFANVVDSCPSW

PF07719 // ENSGT00730000110941_0_Domain_20 (1940, 1973)

AAVYFNRANFYYTLKQYEIAEADLSKALSLKPDDILAXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX

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-----------------------------------------------------VMKCYDL
AKFTIYQVAEMNK---XXXXX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXE--ALKMFKKALDVFSHSDKGPNAVAASSDCLYHMGLCYLEDGNAHMA
LDTFTKAVKANPNF

PF00515 // ENSGT00730000110941_0_Domain_8 (1515, 1547)

AEGFYQRGLCKVKLRKHTSILDFNRAITINPN

ENSGT00730000110941_0_Linker_8_9 (1547, 1548)

H

PF00515 // ENSGT00730000110941_0_Domain_9 (1548, 1583)

YQ--AYLSRAAFY
GLKGRYSKAILNCNEAIKIYPK

ENSGT00730000110941_0_Linker_9_10 (1583, 1584)

S

PF00515 // ENSGT00730000110941_0_Domain_10 (1584, 1618)

VRAYIYRGVLKYYNR-TYQLAIRDLTIAVNMDKNSSI
AFYNRAICYTKINECHMALKDYGIVLLLDAEKNVTFNTFVNRALIYTELKQYGYALEXXX
XXXXXXXXX--XXXX----XXXXXXXXXIR

PF00515 // ENSGT00730000110941_0_Domain_14 (1711, 1729)

EFEEAVSFFSQSLQINPWFLDAFTGRGNSY
MEYHHDKATKQAQKDFLKALHFNPSYSKARISLGYNLQIQGKFQKAWNQFTIAIEIDPKN

PF00515 // ENSGT00730000110941_0_Domain_16 (1801, 1831)

YLAYEGRAVVCLQMGDFFAAVQDINTAIKI

ENSGT00730000110941_0_Linker_16_17 (1831, 1834)

NTT

PF00515 // ENSGT00730000110941_0_Domain_17 (1834, 1867)

AEFLTNRGVIHEFMGQQQNAMKDYQAA
ISLDPTYSLAYFNAGNIYFHHRQFSQAIDYFSKALQFEPGNECATM-NRAIANT---ILK
KYEEAEKDFACIVESCPLW

PF07719 // ENSGT00730000110941_0_Domain_20 (1940, 1973)

SAVYFNRAYFHCCLKQYELAEEDLSKVLSLNPDDALVYNLR
AEVRVKLGLMEEAMDDYNQALDLQDHAPAI

------------------------------------------------------------
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-----------------------------------------------AIARQAGTAMPAR
LLRPRSRHKRRHVKIQGEQV----AKRVFPMSPAHEA-----PGIEAARPRYRQ-ASS--
-LSSLSSETDESGRLRRLR----------IRTHFLREGMGSVR--------WFRPLS--R
AGR-----EMTSGQA-SLQMTRAFPTNIEEIVASLQSEAQMASDQTIKELIQSILGQNYD
LTKEGISLME-QMYFGSSQVP-VQTPELEEEKEFQTTTKERPV-TQNIYEEVPEAVSSIF
QIEQEDISEWGL-LGDENLAFKSQEMLDTVLPEDSTMH--LEPGPPTAAAKKTTKRPSLQ
VRAPEFLHIRGKELKRIQRSRPVVVKPLKRIKSVRSQPEKKIIKKIPQVHPIPHLHDLCC
TVPTAKLPVDLHLASRVYHTPDRTGHKSLLRFLKTSVLGGHSMDD--QRDRIVYGVPVMS
EEQRQINVSPIPPKEFPEWAQTSQRQARQPSLELSGEEMPAYPGTSRMFWNLAAPKFAIP
ESTIRKTLYPKYESVQSSRILIEKLS-ASQESVVISDTYPRRSFKSLILKKSASYENIQK
YSSAPHTRLKRSKSTAELRKEETTPPFIVKDDIDSNLKHLLYQKKTELDRQI--ARQKGI
FEPSIR------SSLET-----VHESESLKYLSISLVEESRKAGITYIVYPRKKKKLWK-
KGLKFQKIALVYEQLSKPPKKL--ERSTSHGILPGQKKFFLKVPVYERQIRSPSVPTILN
FDKFVQSKGGIPEN------------TDPRTWVIEMFAKEKPQKTRIP----V--IHV--
------QKDIPEPVAELPKL--ELNDHVKCDLPPEVIKYYEAEVERLTQEIKNEKRNPVF
AYCRRGAIYRKLGKLQSAMNDLQETIFVEPLFLNAYWHRHFIYLFQDKINDALDDLNFIN
KYNKNHAEAYLSKA

PF13414 // ENSGT00730000110941_0_Domain_1 (1095, 1134)

EIFREKKDYTLAILNYSQAIKCRPKDADLYFKRGELYEKTNSVLAI
DDYSKCIFFDPKRTDAWMKRAMHCFENENWIGAIYDFTALLKLEPRNTRARTNRGRAYSK
RSFYKQATQDFSVAIHLDPNNWLALYYRACLFRKTNPYRALQDYSVSALINDGYDNLNCF
LHRGILYAQLKLWMLAICDFETVISLERTATLAYINIGLIYLLYLDNYTEAFLKFTEAIK
VDPLFIQSYICRAETY-HKLHKLKRAVCELSRAIHLQPDG-IQLYIIRGQYLLMMKCHDL
AKLTIYQVAEMNK---GLIEL--TPIQQALIYSFCENHDKAIHVLEGVIASRPEISTFAL
LAKAQMKAKKIKE--SVRIFKKALEMFSTSDKGPTAVAVS

PF07719 // ENSGT00730000110941_0_Domain_7 (1481, 1513)

AECLYNLGLCYMEEGNLQMA
FDSLTKAVKANPEFAEAFYHRGLCKVKLNKENSILDFNRAITLNPKHYQ--AYLCRVAYY
GLKGRYSKAILNCNEAIRLYPESVRAYICRGVLKYYNR-SYQLAIADLTTAVNMDKNSYA
AFYNRALCYTKIRELQMALRDYGIVLLLDAGERIALNTFINRGLIYTELKQYGFALEDYK
QAALISQTS--VSLCQATAMC----HHRIKEFEGAVEFFTRAVKINRCFLDAYIGRGNSY
MEYGEDEALKRAQKDFLKALHIDPSCLKARISLGYNLQAQGKFQKAWIHFTIALEADPKS
YLAYEGRAVVCLQMSNYFAAMQDINIALKINTTAEFLTNRGVIHEFM

PF13414 // ENSGT00730000110941_0_Domain_17 (1848, 1879)

GQQQNAIADYQAA
ISLDPKYSLAYFNAGNIYLHHRQFSQASDYFSKALAFNPENKHALM-NRAVTNT---LLK
RYEEAEKDFSCAVEHCPHWSALYFNRAIFHFCLKQYELAEEDLGIALTLKPNE

PF13181 // ENSGT00730000110941_0_Domain_21 (1974, 2004)

ADVYNLR
AQVRGKLGLIEEAMSDYNQALDLEECPPAT

--------------------MSTIPKHFGLKHKEESYMFKELEKVRQETKKDFLRFKQKL
ASKPGVGEGRVHSPQAPGPAR-------PARLSRDASRA---SRGSPPAKGPARSAAALL
QEVLGGAPRPSGLGEAAAPGKTRPFLPRDFYLRSSAFLRHPPQKPPPVIASGFGTARPVV
LLPPPEPPAKLRG---LESPRLAGPRRVLDLAKGREESQTVAPLTGPCKARERKVSY---
-VSAGDGSAEAGGGRRKVR----------IRTCFVSESWSPEAP-------EAAGLRARG
ERESWPPCDTRETAGQALLPARVVPTSIQESIASLQSEAQLASDQTIKELIRSVLGQNYD
IRMEDISLMG-KLYLKTSSMQ-AETPQIQAEHRFQIGAEE---SQMNMCKELPEAISSIF
QIEQED-IEWGP-LEVESTVFKPQETLQVRSAEELSKP--LEYGQPT-SDSKEDKPMSLK
AKSSEFLQIKGKQIKRMRKYE-----SLRPRKSSKPRCDKKLHKKIPRDYFTPHLHNLCT
TIPARQLPIDLCLASRVYHTANRKGHSTLLGIFGTSFLDDRFTDEE-QTERILYGIPVMD
DNQEYVHVPLTPRGIPPEFAQGTRERAHKPHLQVLGEEMCAYPEFTKLFWNTAAPKFSVP
ESVMKETLYPKYESVQASRLLTEKFSPETSVLT--LHQYSRKNFSCFLLRKSASLESVQK
CFSAQPTQLRRAKSSVDLRKKETIVPLEIKNDMQSSIKEVMFQKANELKRQLQLLKQNKT
EDP-IPVQENIGDIFGN-----IGEKHSLRNLSLSLIEASKKAGISYIVYPRKKKTKWK-
KRLKQRKLTYVYEELAKPPKSL--ERSESHGILPEQKKYLFKVPLYEHQIRCPSLPLYLN
FEKFVQTKGGIPEN------------SHPRTWALDMLIEHKYQRAP-----IKE-----K
VDKISVLKDPPEIVKEPPKL--KLNDNVESNLPPEVIKHYESEVKILTEEINNKTEYPAF

PF13181 // ENSGT00730000110941_0_Domain_0 (1021, 1050)

AYCRRGAIYRKLGKLQSAMNDLQKAMLLE

ENSGT00730000110941_0_Linker_0_1 (1050, 1088)

PLFLSAYWHRHLIYLFQDKINEALDDLNYIH
KYNKNNT

PF13181 // ENSGT00730000110941_0_Domain_1 (1088, 1119)

EAYLSKAEIYRGKKDITLAILNYTQAIKCRPTDADIYFRRGEMHEIANKVLAI
GDFSKCIFYDPKRTDALLKRGLFYYENENWFAATQDFTALLNIDHQNSQARTYRGIAYVK
QKFYKQATQDFSAAIHLDPNNWLALYYRGCLFRKSNPFRALQDYSISALINDGHENLGCF
LHRGIVYAHLKLWLLAICDFETVISLERTITLAYINIGLIQLLHLDNYTEAIWQFSEAIR
IDPLCIQSYICRAETY-FKLHKLKKAVNELSRAIHLQPDG-IQLYIRRGQYLLMMRCYNL
AKFTIYQVAEMDK---GLIEL--SPVQQALIYSFCENHDKAIEVLDGISWNRTDMTMYAL
LAKVQMKAKRTKE--AVRTLKTALDVISHSNKGPNATTIS

PF13181 // ENSGT00730000110941_0_Domain_7 (1481, 1513)

ADCLYNLGLCYKEEGNLQMA
FNSFTKAVKANPDSAESFYQRGLCKAKLYKDSSILDFNCAVTLNPKHYQ--AYLSRVAFY
GLKGRYSKAILNCNMAIKIYPEGVRAYLYRGVLKYYNK-TYKLAITDLTTAINIDKNSYI
AFYNRALCYTKIRELQMALTDYGVVLLLDARETVKLNTFLNRGLIYIELGQYGFALEDFK
QAALISQTN--GSLYHATAMC----HHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSY
MEYGLDEATKKAQKDFLKALHINPGYIKARISLGYNLQIQGKFQKAWNHFTIAMDIEPKN
YLAYEGRAVVCLQMGNNFAAMQDINAAMKINTTAEFLTNRGVIHEFMGHKQNAMKDYQEA
ISLNPKYS

PF07719 // ENSGT00730000110941_0_Domain_17 (1869, 1901)

LAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLM-NRAIANT---ILK
KYEEAKEDFANVIERCPFW

PF00515 // ENSGT00730000110941_0_Domain_20 (1940, 1973)

AAVYFNRAHFYYCLKQYELAEEDLSKALSLKPNDALAYNFR
AKVRGKIGLSEEAVADYSQALDLEDRASFT

--------------------MSTIPRHFGLKYKEESYMFKELEKVRQETKKDFLRFKQKL
ASKPAVDESRVHSLHAPGPAR-------PVRVSCAAAGT---SRGYPPAKGPAMSAAALL
QEVLGSAPRASGLREAAAPGKTWSFRPRDFYLQSSASLRHQALKKPLVIASGFGTARPVV
LLPPPEPPVKRRARGALESSRHAAPRRVLDLGRGRKESQEVAPLAGPCMAKERKASS---
-VSAEDSYMEASSGRRKVR----------IPTHFVSESGAREAR-------EAAGLGTQG
EQESWPLSDGREAACQALLPARVIPTSIEEIIGSLQSEAQLASDQTIKELIRSVLGQNYD
VRMEDISLTG-KMYPNTSPMQ-AETPEMQAEYKFQMGAEE---SQMSVHKELPETMSSIL
QIEQED-IEWGP-SEAESTVFKPQEISQVQPAEELSKP--LEDGQPT-SDSKEAKWVSLT
AKSPEFLQIEGKEIKRMQKRK-----SLRPRKSSKPLCDKKLHKKIPQDYSMPRLHDLCT
TIPAQGLPVDLSLASRVYHTANRKGHDTLLGKFGTSFLDDRFTDEE-QTDRILHGISVMD
DNQEYVHIPPTPQGIPPELAQGSRERAHKPHLQVLGKKMCAYPEFTKLFWNTAAPKFSVP
ESVMKETLYPKYESVQASRLLTDKFSYKSSVIT--LHQHSRTNFGCFLPRKSASFESIQK
WFSAQPTQLRRVKSSVDLRKEEIIAPLEIKNDMQSSIKEVMFQKAKELERQLQLTKQNKT
EEP-NYVKENIDDIFDN-----MCEKHSSRNRSSNLVEASKKAGISYIVYPKKKKMKRK-
KRLKQQKLKFVYEELSKPPKSL--ERSASHGILPEQKKYLFKVPLYERQIRCPSLPSYLN
FEKFVQANGGIPEN------------IDPWTWALDRLIEYKDASTP-----VKE-----K
DDKISVPKDPPERVKEPPKL--KLNDYVESDLPQEVIKYYESEVKILTEEINDKTKYPAF

PF13181 // ENSGT00730000110941_0_Domain_0 (1021, 1050)

AYCRRGAIYRKLGKLQSAMNDLQRVMLLE

ENSGT00730000110941_0_Linker_0_1 (1050, 1088)

PLFLNAYWHRHLIYLFQDKINEALDDLNYIH
KYNKNNT

PF13181 // ENSGT00730000110941_0_Domain_1 (1088, 1119)

EAYLSKAEIYRGKKDITLAILNYTQAIKCRPTDADIYFRRGEMYEIADKVLAI
DDFSKCIFYDPKRTDALMKRGLFYYENENWFAAIEDFTALLNIDHQNSQARTYRGIAYVK
RKFYKEATQDLSAAIHLDPNNWLALYYRGCIFRKSNPFTALQDYSVSALINDGYENLGCF
LHRGIVYAHLKLWQLAICDFETVISLDRTITLAYVNIGLIHLLHLDNYTEAIWQFSEAIR
IDPLCIQSYLCRAEAY-FKLHKLKKVVNELSRAIHLQPDG-IQLYIRRGQYLLMMKCYDL
AKFTIYQVAEMDK---GLTEL--SPVQQALIYSFCENHDKAIEVLDGISWNGAEMTTCAL
LAKVQMKAKRTKE--AVKTLKKALDAISHSDKGPNATAIS

PF00515 // ENSGT00730000110941_0_Domain_7 (1481, 1514)

ADCLYNLGLCYMEEGNLQMA
FDSFTKAVKANPDFAESFYQRGLCKVKLRKDSSILDFNRAITLNPKHYQ-

PF13181 // ENSGT00730000110941_0_Domain_9 (1551, 1582)

-AYLSRAAFY
GLKGRYSKAILNCNKAIEIYPESIRAYLYRGVLKYHNK-TYKLAITDLTTAISMDKNNYI
AFYNRALCYTKIRELQMALTDYGIVLLLDATETVKLNTFLNRGLIYVELDQYGFALEDFK
QAALISQTN--ES

PF13181 // ENSGT00730000110941_0_Domain_14 (1694, 1727)

LWHATAMC----HHRINEFEEAVNFFTRALKIKPCFLDSYVGRGNSY
MEYGHDEATKQAQKDFLKALHINPACIKARISFCYNLQAQGKFQKAWNHFTIAIDIDPKN
YLAYEGRAVVCLQMGNNFAAMQDINAAMKINTT

PF13181 // ENSGT00730000110941_0_Domain_17 (1834, 1866)

AEFLTNRGVIHEFMGHKQDAMKDYQDA
ISLNPKYSLAYFNAGNIYFHHRQFSQ----------------------------------
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------------------------------

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-------------------------------------LIKRLRIFS--------QMYFRI
YYPMPVSPLHVGE--AVRIFKKTLDIFSHSDKGPNATAISADCLYNLGLCYMEEGNLQMV
FC----------------------------------------------------------
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-----------------ALIDYGIVLLLHAGETITLNTFINRGLIYSELEQYGFALEDFK
QAALISETN--VNLCQAAAMC----HHRIKEFEEAVNFFTWAIKINPCFLDAYIGRGNSY
MEYGHGEATNQAQKDFLKALHFNPSYVKSRI

PF13432 // ENSGT00730000110941_0_Domain_16 (1772, 1817)

SLGYNLQAQGKFQKAWRHFTIATEVDPKS
YLAYEGRAVVCLQMGN

ENSGT00730000110941_0_Linker_16_17 (1817, 1834)

NFAAMQDINTAIKINTT

PF13181 // ENSGT00730000110941_0_Domain_17 (1834, 1866)

AEFLTNRGVIHEFMGQRQNAMKDYQAA
ISLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALMFDPGNKYVLM-NRAIANT---ILK
KYEEAKEDFAYAIESCPFWAAIYFNRAQLYCCLKQYELAEEDLSKALSLVPNDAV

PF13181 // ENSGT00730000110941_0_Domain_21 (1976, 2004)

VYNLR
AKVRGKIGLIEEAMADYNQALDLEEYASVT

--------------------MSTIPRHFGLKYKEESYMFKELEKVRQETKKDFLRFKQKL
ASKPAVDERPVHSLHAPGAAR-------PERVSRSAART---SRGSPSAKGPAMSAAALL
QEVLGGAPRPSGLGEAAAPGKTLSFRPRDFYLRSSAFLRHQTLKKPPVIASGFGTARPVV
LLPPPEPPVKRRACRVLGSSRHAAPRPVLDLVRGREESQEVAPLSGPCMAKDSKVSS---
-ISTEDGYTDVSSGRRKVR----------IRTHFMSESRAREAR-------EAAGLGAQG
EQESLPPSDAREAAWQALLPARVIPTSIEEIIASLQSEAQLASDQTIKELIRSILGQNYD
IRMEDISLMG-KMYRKTSSMQ-AETPEIQAEHGFQMGAEE---SQTSMHKELPETMSSIL
QIEQED-IEWGT-SEVESTVFKPQEISQVQPAEELSKP--LEDGQPT-SDSKEAKRVSLT
AKSSEFLQIEGKEVKQMQKRI-----SLRPRKSSKPLCDKKLREKIPRDYSMPHLHDLCT
TIPAQELPIDLRLASRVYHTANRKGHNTLLGKFGTSFLDDHFTDEE-QADRILYGIPVMA
DNQEYVHIPLTPQGIPPELAQGTRERAHKPHLQVLGEEMCAYPEFTKLFWNTAAPKFSVP
ESVMKETLYPKYESVQASRLLTDKFSYKSSAIT--FRRHSRTNFWCFLSRKSASFENIQK
WFGAQPTQLRQVKSAVDLRKEDIIAPLEIKNDMQSSIKEVMFQKTKELKRQLQLTKQNKT
EEP-IPVKKNIDDILDN-----MCEKHSLRNLSLTLIEASKKAGISYIVYPKKKKMKWK-
KRLKQQKLIFVYQELSKPPKSL--ERSTSHGILPEQKKYLFKVPLYERQIRCPSLPLYLN
FEKFFQTKGGIPEN------------IDPRTWAFDRLIADKDASTP-----VKE-----K
DDKISVPKDPPERVKEPPKL--KLSDDVESDLPQEVIKHYESEVKILTEEINDKTKYPAF

PF13181 // ENSGT00730000110941_0_Domain_0 (1021, 1050)

AYCRRGAIYRKLGKLQSAMNDLQRVMLLEPLFLNAYWQRHLIYLFQDKINEALDDLNYIH
KYNKNNTEAYLSKAEIYRGKKDVTMAILNYTQAIKCRPTDADIYFRRGEMYEIANKVLAI
DDFSKCIFYDPKRTDALLKRGLFYYENENWFAAIEDFTALLNIDHQNSQARTYRGIAYVK
RKFYKEATQDFSAAIHLDPNNWLALYYRGCLFRKSNPFRALQDYSVSALINDGYENLGCF
LHRGIVYAHLKLWLLAICDFETVISLERTTTLAYVNIGLIHLLYLDNYTEAIWQFSEAIR
IDPLCIQSYLCRAETY-FKLHKLKKAVNELSRAIHLQPDG-IQLYIRRGQYLLMMKCYDL
AKFTIYQVAEMDK---GLIEL--SPIQQALIYSFCENHDKAIEVLEGISWNRAEMTMYAL
LAKVQMKAKRTKE--AVKMLKKALDVISHSDKGPNTTAIS

PF00515 // ENSGT00730000110941_0_Domain_7 (1481, 1514)

ADCLYNLGLCYMEEGNLQMA
FDSFTKAVKANPDFAESFYQRGLCKVKLHKDSSILDFNRAITLNPKHYQ--AYLSRVAFY
GLKGRYSKAILNCNKAIKIYPESVRAYLYRGVLKYYNK-TYKLAITDLTTAISMDKNSYI
AFYNRALCYTKIRELQMALTDYGIVLLLDATETVKLNTFLNRGLIYLELDQYGFALEDFK
QAALISQTN--ESLCHATAMC----HHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSY
MECGHAEATKQAQKDFLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDIDPKN
YLAYEGRAVVCLQMGNNFAAMQDINAAVKINTT

PF13181 // ENSGT00730000110941_0_Domain_17 (1834, 1866)

AEFLTNRGVIHEFMGHKQNAMKDYQDA
ISLNPKYSLAYFNAGNIYFHHRQFSQASGYFSKALKFDPENEYILM-NRAITNT---ILK
KYEEAKGDFANVIERCPFW

PF00515 // ENSGT00730000110941_0_Domain_20 (1940, 1973)

AAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFR
AKVRCKIGLIEEAMADYNQALHLEDHNSVI

MSLQHFPLNHTVLDRKTYNKMSRVPKHFGLNYNEELNMLKELEKVRKNTRKEFLKFKEVQ
ESKSKQSSLQFSSVSDLTSQSSE------SSLETISVD----KIVSPELTTSALPDTEKR
SHAPRRKRQES-KLPLKVKSEKPRFCHKEYYMKINPYIYQH-GKAKPVIASLAGTSKQAV
LFKQPAPSQKPRYRRV--ILRRKAPSPQFTLPLGKEGRKS-----EVTSVPESLPSDEIS
LKGSIASDQESEKVLLRKRRSGPRRREGSLIEKKMKKSLTPSRIEDIEQKEEPQTEILTE
EKEEIVPEE--SQGP-TPGRMVKIPRSIEEIIANLQSERQTVVDNMIKDLIESVLGQNYD
IKMEEVSLMTNFKFEEEIEKEKSEVKKVAEEEVL-VEK--------EEDKIESEDEVDIE
QIEQEEDLEETKTVQERENVELLQTVLDTKILSELPMF--LDT---TETQLPKREPGAFQ
VVSLESLQIKGKTVPASPRIKPKF-----QRRPFETSESPKTTSKIPEK-STHNLHKLCT
TSPECVLPTDLQLASRIYHTLGKKGHDFFMESDKKDLKDEHTKN-EKIRDRILYGVSTSD
AKGKTEKSSSEKP----TALVKVKTTDQQPSFQLLGEEVPLYPGSVKMFWTLAPPKFSAP
VSLIRQTLYPQYESSCTFRQTMDKSLSVSEESFYSKDREKKSEKPKFKVMKSKSLTTLPK
IDEAK-KMINKAASVFNFAMQNDSISSIVPDDIRSNLNELENQQEYFLKCLE--ENENNM
YDY-L----DITDLPET----ETQKSGQKK----THPKDVSQKTRRFIVFPRRKRRKLR-
KRLSSEKLKFVLNELAKPPQTL--KRSKSLVILLQQKKFFLRVPIYVRRSRCPSLPSVLN
FDKFVEKHGGIPKN------------IRPYHWALDFWISEYHEFAPSPEPEFVEQGTVQT
APVETVPAVPIIETKNLSKI--ELDDFINPDLSEHVVQYLEKEIEKLTQELKQKQKMPA

PF00515 // ENSGT00730000110941_0_Domain_0 (1020, 1050)

F
LYCRRGAIYRKLGKLKMAMDDLQEAIFLEPLLLNAYWHRHFIYLFQNRTGDALDDLNFIT
KYNRKNADVYLSKAEIFKKRGNQTLALLNYTQAIKCRPKDDDIYFKRAEMLLAGNKLLAI
DDYSRCISLNPKKAEAYLRRGIYHFENSNWSPAIQDFSALLNLDYKNIQARTYRGRAFFK
RGFFRDATEDLSIAIHYDPNNWIAFYYRGCIFRKSNPNKALQDFSISVLINDTLENILSF
LHRGILYAEMSSWGLAIADFESVLNLDRKIAFAHINIGLIYMLHLDKYFEAIYEFTEAIR
VDPLCIQSYLCRAQTY-YKLHKLSQAIKDMSRVIHLQPDG-IQLYIIRGRYLLEMKCHDL
AKSTIFQVAQMNK---GSFEL--SPIQQSLVFSFCNYHREALKLLFSVTLYKPEPGMFIL
LGKAQMKAKKLKVRNINNFYYMCLEIMSNSDKIPKGSFLPAEC

PF00515 // ENSGT00730000110941_0_Domain_7 (1484, 1514)

SFLLGLCYMKEDNLYMA
IESFNKAVKAYPDYPEAFYQRGLCKVKVQRDKCVQDFNRAITLNPKHYK-

PF00515 // ENSGT00730000110941_0_Domain_9 (1551, 1582)

-AYISRAAFY
GLKGRYSKAILNCNEAIRIFPNSVRAYLYRGVLKFYNK-TYKLAITDLNIAISLNKNCFL
AFYNRAICFSKIKEFDSALKDYGIVLLLDVGDDIRAKTLINRGLIYTELKMTANALADFR
EAMHISEDN--ASLFQAAGIC----HHRIGEYEEAVCSFTRVIELNPFFVDAYVGRGNSY
MEYGHEAAERQAQKDFLKALHFNPAHLNARISFGYNLQGKGKFQKAWNQFTICVDIDPGN
YQAYEGRGIVCLQMGNNFAAIQDINSALKITTSAEFLTNHGVIHEFMGERHIAMKDYQAA
ISMNPKYS

PF07719 // ENSGT00730000110941_0_Domain_17 (1869, 1901)

LAYFNAGNIYLHHRQFSQAIEFYSKALHFDPQNDSAAL-NRAITNT---ILQ
KFEEAKEDFIKAIELCPFWGA

PF00515 // ENSGT00730000110941_0_Domain_20 (1942, 1973)

VYYGKALLYYSLQQYEIAEEDLTKALSLQPNDHLAYKLR
ADIRGKMGKTEEALKDYNQSLDLQEFASY-

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QAALINQTN--VSLCQATAMC----HHRIKEFEEAVNFFTWVLKINPCFLDAYIGRGNSY
MEYGHDEATKQAQKDFLKALHLNPSCIKARI

PF13432 // ENSGT00730000110941_0_Domain_16 (1772, 1816)

SLGYNLQAQGKFQKAWNHFTIAIEVDPRS
YLAYEGRAVVCLQMG

ENSGT00730000110941_0_Linker_16_17 (1816, 1848)

NNFGAMQDINAAMKINTTAEFLTNRGVIHEFM

PF13414 // ENSGT00730000110941_0_Domain_17 (1848, 1879)

GQQQNAMKDYQAA
ISLNPEYSLAYFNAGNIYFHHRQFSQAGDYFSKALKFDPENEYILM-NRAIANT---ILK
KYEEAKEDFAYVIESCPFW

PF07719 // ENSGT00730000110941_0_Domain_20 (1940, 1973)

AAAYFNRAYFYCCLKQYELAEEDLNKALSLKPNDALVHSFR
AKVRGKIGLIEEAMTDYNQALDFEGYASVI

--------------------MSTIPKHFGLKHKEESYMFKELEKVRQETKKDFLRFKQKL
ASKPGVGEGPVHRPHAPGPAR-------PARLSRAAART---SRGSPPAKGPVRSAAALL
QEVLGGAPRPSGPGEAAAPSKTRPLLPRDFYLRSSAFLRHLPQKKPPVIASGFGTARPVV
LLPPPEPPAKRRG---LESPRPAGSRRVLDLARGREESQAAAPLAGPCRARERKVSS---
-VFAGDGSAEAGGGRRKVR----------IRTCFVSESWAREAP-------EAAGLRARG
ERESWPPCDTREAAWQALLPARVVPTSIEEIIASLQSEAQLASDQTIKELIRSVLGQNYD
IRMEDISLMG-KTYLKTSSMQ-AETPQIQAEHRFQMGAEE---SQMSMRKELPEAISSIF
QIEQED-VEWGP-LEVESTVFKPQETLQVQPAEELSKS--LEHGQPT-SDSKEAKPMSLK
AKSSELLQIKGKQIKRMQKRK-----SLRPRKSSKPLCDKKLLKKIPRDYSMPHLHNLCT
TIPARQLPIDLCLASRVYHTANRKGHNTLLGIFGTSFLDDRFTDEE-QTERILYGIPVMD
DNQEYVNVPPTLRGIPPELAQGTRGRAHKPHLQVLGEEMCGYPEFTKLFWNTAAPKFSVP
ESVMKETLYPKYESVQPSRLLTERLSPETSVLT--LHQYSRTNFSCFLLRKSASLESVQK
CFSAQPTELRRAKSSVDLRKEEIIAPLEIKNDMQSSIKEITFQKANELKRQLQLLKQNKT
EDP-IPVKENIDDIFEN-----ICEKHSLRNLSLSLIEASKKAGISYIVYPKKKKTKWK-
KRLKQRKLTFVYEELAKPPKSL--ERSESHGILPEQKKHLFKVPLYERQIRCPSLPLYLN
FEKFVQMKGGIPEN------------SDPRTWALDTLIEHKYQRTP-----IKE-----K
VDKISVLKDPPEIEKEPPKL--KLNDNVESNLPPEVIKHYESEVKILTEEINNQTEYPVF

PF13181 // ENSGT00730000110941_0_Domain_0 (1021, 1050)

AYCRRGAIYRKLGKLQSAMNDLQKAMLLEPLFLNAYWHRHLIYLFQDKINEALDDLNYIH
KYNKNNTEAYLSKAEIYRGKKDVTLAILNYTQAIKCRPTDADIYFRRGEMHEITNKVLAI
DDFSKCIFYDPKRTDALLKRGLFYYENENWFAAIQDFTALLNIDHQNSQARTYRGIAYVK
RKFYKQATQDFSAAIHLDPNNWLALYYRGCLFRKSNPFRALQDYSVSALINDGYENLGCF
LHRGIVYAHLKLWLLAICDFETVISLERTITLAYINIGLIQLLHLDNYTEAIWQFSEAIR
IDPLCIQSYICRAETY-FKLHKLKKAVNELSRAIHLQPDG-IQLYIRRGQYLLMMKCYNL
AKFTIYQVAEMDK---GLIEL--SPIQQALIYSFCENHDKAIEVLDGISWNRTDMTMYAL
LAKVQMKAKRTKE--AVRTLKKALDVISHSDKGPNATAIS

PF00515 // ENSGT00730000110941_0_Domain_7 (1481, 1514)

ADCLYNLGLCYMEEGNLQMA
LDSFTKAVKANPDFAESFYQRGLCKAKLHMDSSILDFNCAITLNPKHYQ--AYLSRVAFY
GLKGRYSKAILNCNMAIKIYPDSVRAYLYRGVLKYYNK-TYKLAITDLTMAINMDKNSYI
AYYNRALCYTKIRELRMALTDYGIVLLLDTTENVKLNTFLNRGLIYIELGQYGFALEDFK
QAALISQTN--GSFYHATAMC----HHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSY
MEYSLDEATKKAQKDFLKALHINPGYIKARISLGYNLQIQGKFQKAWNHFTIAMDIDPKN
YLAYEGRAVVCLQMGNNFAAMQDINAAMKINTT

PF13181 // ENSGT00730000110941_0_Domain_17 (1834, 1866)

AEFLTNRGVIHEFMGHKQNAMKDYQEA
ISLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLM-NRAIANT---ILK
KYEEAKEDFANVIERCPFW

PF00515 // ENSGT00730000110941_0_Domain_20 (1940, 1973)

AAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFR
AKVRGKIGLSEEAMADYNRALDLEDYASVT

--------------------MSTIPRHFGLKYKEESYMFKELEKVRQETKKDFLRFKQKL
ASKPAVDESPVHSLHAPGPAR-------PARVSCAAART---SRRYPPPKGPAMSAAAFL
QEVLGGAPRPSGLGEAAAPGKTQSFRSRDFYLRSSAFLWHQALKKPPVIASGFGTARPVV
LLPPPEPPVKRRARGVLESSRHAAPRRVFDLGREREESQEVAPLAGPCMAKERKASS---
-VSAEDGYTEASSGRRKVR----------IRSNFVSESGAREAR-------EAAGLGAQG
EQESWPPSDAREAAWQALLPSRVIPTSIEEIIASLQSEAQLASDQTIKELIRSVLGQNYD
ITMEDISLMG-KMYLKTSPMQ-AETPEIQAEYKFQMGAEE---SQMSVHKELPETMSSIL
QIEQED-IEWGP-SEAESIVFKPQEISQVQPAEELSKP--LEDGQPT-SDSKEAKWVSLT
AKSPEFLQIEGKEIKRMQKRK-----SLRPRKSSKPLCDKKLHKKIPQDYSMPHLHDLCT
TIPAQELPVDLRLASRVYHTANRKGHDTLLGKSGTSFLDDRFTDEE-QTDRILYGIPVMD
DNQEYVHSPPTPQGIPPELAQGTRERAHKPHLEVLGEEMCAYPEFTKLFWNTAAPKFSVP
ESVMKETLYPKYESVQASRLLTDKFSYKSSVIT--LHQHSRTNFWCFLPRKSASFESIQK
WFSAQPTQLRRVKSSADLRKEKIIAPLEIKNDMQSSIKEVMFQKAKELKRQLQLTKQNKT
EEP-NHVKENIDDIFDN-----MCKKHSLRNLSLTLIEASKKAGISYIVYPKKKKMRWK-
KRLKQQKLIFVYEELSKPPKSL--ERSASHGILPGQKKYLFKVPLYERQIRCPSLPLYLN
FEKFVQAKGGIPEN------------IDPRTWALDRLIEYKDASIP-----VKE-----K
DDKISVPKDPPERVKEPPKL--KLNDYVESDLPQEVIKYYESEVKILTEEINDKTKYPAF

PF13181 // ENSGT00730000110941_0_Domain_0 (1021, 1050)

AYCRRGAIYRKLGKLQSAMNDLQRVMLLE

ENSGT00730000110941_0_Linker_0_1 (1050, 1088)

PLFLNAYWHRHLIYLFQDKINEALDDLNYIH
KYNKNNT

PF13181 // ENSGT00730000110941_0_Domain_1 (1088, 1119)

EAYLSKAEIYRGKKDITLAILNYTQAIKCRPTDADIYFRRGEMYEITNKVLAI
DDFSKCIFYDPKRTDALLKRGLFYYENENWFAAIEDFTALLNIDHQNSQARTYRGIAYVK
RKFYKEATQDFSAAIHLDPNNWLALYYRGCLFRKSNPFRALQDYSVSALINDGYENLGCF
LHRGIVYANLKLWLLAVCDFETVISLERTITLAYVNIGLIHLLHLDNYTEAIWQFSEAIR
IDPLCIQSYLCRAETY-FKLHKLKKAVNELSRAIHLQPDG-IQLYIRRGQYLLMMKCYDL
AKFTIYQIAEMGK---GLSEL--SPMQQALIYSFCENHDKAIEVLDGISCNRAEMTMCAL
LAKVRMKAKRTKE--AVEVLKKALDAISHSDKGPDATAIS

PF00515 // ENSGT00730000110941_0_Domain_7 (1481, 1514)

ADCLYNLGLCYMEEGNLQMA
FDSFTKAVKANPDFAESFYQRGLCKVKLHKDSSILDFNRAITLNPKHYQ--AYLSRVAFY
GLKGRYSKAILNCNKAIKIYPESVRAYLYRGVLKYYNK-TYKLAITDLTTAISMDKNSYI
AFYNRALCYTKIRELQMALTDYGIVLLLDATETVKLNTFLNRGLIYVELDQYGFALEDFK
QAALISRTN--GSLCHATNASIFLFICRINEFEEAVNFFTWALKINPCFLDAYVGRGNSY
MEYGHDEATKQAQKDFLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKN
YLAYEGRAVVCLQMGNNFAAMQDINAAMKISTTAEFLTNRGVIHEFMGHKQNAMKDYQDA
ISLNPKYS

PF07719 // ENSGT00730000110941_0_Domain_17 (1869, 1901)

LAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLM-NRAITNT---ILK
KYEEAKEDFANVIESCPFW

PF00515 // ENSGT00730000110941_0_Domain_20 (1940, 1973)

AAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFR
AKVRGKIGLIEEAMADYNQALDLEDYASVI

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-----------------------------------------------------RMKCYDL
AKFTIYQVAEMNK---GLIEM--SPIQQALIYSFCENHDKAIQVLDGATLNKPE

PF00515 // ENSGT00730000110941_0_Domain_6 (1435, 1470)

INIIIL
LAKTQMKAKRTKE--AVKLFKKALDVCSHSERGPHALEATVDCLYNLGLCYMDEGNLQTA
FESFTKAVKLNPNF

PF00515 // ENSGT00730000110941_0_Domain_8 (1515, 1547)

AEGFHQRGLCKVKLHKDSSILDFNRAITLNPN

ENSGT00730000110941_0_Linker_8_9 (1547, 1548)

H

PF00515 // ENSGT00730000110941_0_Domain_9 (1548, 1583)

YE--AYLNRVAFY
GLKGRYSKAILNCNEAINIYPQSVRAYIYRGVLKYHNR-TYKLAITDLTTAINMDKNS

PF00515 // ENSGT00730000110941_0_Domain_11 (1619, 1652)

YV
AFYNRAVCYTKIGELQMALMDYGIVLLLDAG

ENSGT00730000110941_0_Linker_11_12 (1652, 1656)

KTVA

PF00515 // ENSGT00730000110941_0_Domain_12 (1656, 1689)

FNTLVNRGLIYLGQGHHCFALEDFK
QAALLSKT

ENSGT00730000110941_0_Linker_12_14 (1689, 1692)

N--

PF07719 // ENSGT00730000110941_0_Domain_14 (1692, 1729)

VNLCQATALC----YHRNKEFAEAVTFFTLALSINPYFLDAYIGRGNSY
MEYGHDEGIKQAQKDFLKALHYNPICTKARVSLGYNLQAQEKFQKAWNHFTIAIEVDPKS

PF00515 // ENSGT00730000110941_0_Domain_16 (1801, 1831)

YLAYEGRAVVCLQMGNNFAAIQDINMAIKINTTAEFLTNRGVIHEFMGQQQNAMRDYQAA
ISLNPTY

PF07719 // ENSGT00730000110941_0_Domain_17 (1868, 1901)

ALAYFNAGNIYFHHRQFSQASDYFSKALKFDPENECATM-NRAIANT---ILK
KYEEAKEDFANVVESCPFWAAVFFNRAQFYCCLKQYELAEEDLSKALSLNPSD

PF00515 // ENSGT00730000110941_0_Domain_21 (1974, 2007)

ALVYNLR
AEVRGKMGAIEEAMADYNQALDLQEYAKII

--------------------MSSIPKHFGLKYREELCMHKELEKVRKETKKDFLRFKQTL
ASKPAIDEGPVHGPRPPRFQA--LGRTSPGEKEHISHAGPGKPSGSPRAKVPGTPAAALL
QEAPRGVLHPAGPGEAAAPAQTRPFRPQDFYLRSSAYLRHPPPRKPPVIAPGAGTARPAV
LLPPRAPPLKPGARLGGLSPQPAASRPVPELAPGRDAGAETAPPAEVRKARQRLTSAT--
-ESSEDSDAEAATRRGRVR----------ICTHPLSDVQEPRE--------AAGPDVSRT
VGKSLLPSDALEAGP-ALLPARAVPTSIEEIIASLQSEAQRASDQTIRELIQSVLGQNYD
LNMEEKVFILGKSFLNTGPLQSCVTPQMQAEQGLQKS--VEELQMQTLLEELPEAVSSIF
QIEQEDISEWGV-SEVGSILFKPQEISEVQPAEESQKP--SENGQPT-GVSKVVKQISLK
VKSSELLQIRGKEVKRVRKSKLG-IP-QQKPKSLKPSWDQKLSKNVPRAHPVLNHHELCT
TVPAQGLPTALHLASRVFHTADRKGHNALLGIFGTSFSDDCSTDEE-QRDRILHGIPVLG
DHQEYVTAPPATPERLPELTQGTGYRAHKPQMLLLGEEVSFYPGLTKLFWNPTAPKFSVP
VSVMKETLYPKYESVQTSKILVEKFSSDSKKSVISLNQYSRRNYETFLLRKSASLDSIKI
CFRAQSPPLKRAKSAVELRKEETTAPLQIQNDAQSNIKGVMFQKRKGLERQI--AEQIKS
KEPTTE-KENIEITLEN-----MQDRQSLRNLSVYLIEASRKAGISYIVYPKKKKMLWN-
KGLSFEKFTSVCEELAKPPQILKSTRSQSHGILLEQKKYLFKVPLYERQIRSPSLPVCLN
FEEFIQSKGGIPKN------------TDQRKWIIDLWFKYKSQRIAEREDVAK--VSF--
------YKDRPAEEKEPPRL--ELSDFLGSNLPPEIIKYYESEVELLTEEINNKKTKSAF
LYCRRGAICRKLGKLQSAMNDLQEAIFLEPMFLNAYWHRHFIYLFQDKINDALDDLNFIN
KYNKNNADVYLSKAEIFKKKGDISLAILNYTQAIKCKPTNADIYFKRGEMYEISNRVLAI
DDFSKCIFYDPQRTDALLKRGKYYYENENWIAAIHDFTDLLNIDHQNSQARTYRGRAYFK
RHFYKQATQDLSAAIHLDPNNWLALYFRACLFRKTNPSRALQDYSVSALINDGYENLSCF
LHRGILYADLKNWFMAICDFETVISLERTFPLAYINIGLIHLLYLENYIEAIWQFSEAIR
IDPLYIQSYICRAESY-HKLHKWKQAVKDLSRAIHLQPDG-IQLYIIRGQYLLTMRRYDL
AKFTIYQVAEMNK---GLIEL--SPIQQALIYSFCENHGKAIQVLNVITLSKPEITMYAL
LAKAQMKAKRNKE--AVRTFKKALDVFSHSDKGPNTTVAS

PF07719 // ENSGT00730000110941_0_Domain_7 (1481, 1513)

ADCLYNLGLCYMEEGNLQMA
YDSFTKAVKANPECAEAFYQRGLCKVKLQKDNSILDFNYAITLNPKYYQKKAYLSRVAYY
GLKGRYSKAILNCNEAIKIYPESVRAFLYRGVLKYYNKKTFMLSYTKLTTAINMDKNSYV
AFYNRAICYTKIKELQMALIDYGVVLLLDAGESITLNTFINRGLIYTELEQYGFALEDFK
QAALISQTN--VNLCQAVAMC----HHRIKEFEEAVHFFTWALKINPHFLDAYVGRGNSY
MEYGHDAATKQAQKDFLKALHFNPMYTKARISLGYNLQAQGKFQKAWNHFTITMEVDPKS
CLAYEGRAVVCLQMGNNFAAVQDINAAIKINTTAEFLTNRGVIHEFMGQKQNAMKDYQAA
ISLNPKY

PF00515 // ENSGT00730000110941_0_Domain_17 (1868, 1901)

ALAYFNAGNIYFHHRQFSQANDYFSKALKFDPGNECVLM-NRAITNT---ILR
KYKEAKEDFANAIESCPFW

PF00515 // ENSGT00730000110941_0_Domain_20 (1940, 1973)

AALYFNRANFYCCLKQYEIAEEDLSKALSLHPNDAAAYNL-
------------------------------

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AKFTIYQVAEMNK---GLIKL--SPIQQALVYSFCENHDKAIQVLDGLILNRPDITTYTL
LAKTQMKAKRRKE--AMRMLKKALEVFSHSDKGPNAVAAS

PF07719 // ENSGT00730000110941_0_Domain_7 (1481, 1513)

ADCLYNLGLCYMDEGNLQMA
LDSFTKAVKANPDFAECFYQRGLCKVKLHKDNSILDFNRAITLDPKHYQ--AYLSRVAFY
GLKGRYSKAILNCNEAIRIYPQSVRAYISRGVLKYYNK-TYKLAITDLTTAINMDKNSYV
AFYNRALCYTRIGELQMALTDYGIVLLLDAGETVTLNTFINRGLIYVELEQYSFALEDFK
QAALISKTS--VSLCQAT

PF00515 // ENSGT00730000110941_0_Domain_14 (1699, 1729)

AIC----HHRNKEFEEAVDFFTWALKINPHFLDAYVGRGNSY
MEYGRDEATKQAQKDFLKVLHFNPAYTKARISLGYNLQAQEKFQKAWNHFTVAIEVDPKS
HLAYEGRAVVCLQMGDNSAAIQDINAAIKINTTAEFLTNRGVIHQFMGQQQNAMKDYQAA
ISLNPEYSL

PF00515 // ENSGT00730000110941_0_Domain_17 (1870, 1901)

AYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYATM-NRAIANT---ILK
KYKEAEEDFANVVKNCPSW

PF00515 // ENSGT00730000110941_0_Domain_20 (1940, 1973)

AAVYFNRAHLHCCLKQYELAEGDLTEALSLKPNDALVYNLR
AEVRGKIGLIEDAMADYTRALDLQEYGSVI

MR----RGIRIRRSEVKFIKMSTIPRHFGLKYKEESYMFKELEKVRQETKKDFLRFKQKL
ASKPAVDERPVHSLYAPGAAR-------PERVSCAAART---SRGSPSAKGPAMSAAALL
QEVLGVAPRPSGLGEAAAPGKTLSFRPRDFYLRSSAFLRHHTLKKPPVIASGFGTARPVV
LLPPPEPPVKRRACRVLGSSRHAAPRPVLDLGREREEGQEVAPLSGPCMAKERKVSS---
-ISTEDGYTDVSSGRRKVR----------IRTHFMSESRAREAR-------EAAGLGAQG
EQESLPPSDAREAAWQALLPARVIPTSIEEIIASLQSEAQLASDQTIKELIRSILGQNYD
IRMEDISLMG-KMYRKTSSMQ-AETPEIQAEHRFQMGAEE---SQTNMHKELPEAMSSIL
QIEQED-IEWGT-SEVESTVFKPQEILQVQPAEELSKP--LEDGQPT-SDSKEAKRVSLT
AKSSEFLQIEGKEVKQMQKRV-----SLRPRKSSKPLCDKKLREKIPRDYSMPHLHDLCA
TIPARELPIDLRLASRVYHTANRKGHNTLLGKFGTSFLDDHFTDEE-QADRILYGIPVMD
DNQEYVHIPLTPQGIPPELAQGTRERAHKPHLQVLGEEMCAYPEFTKLFWNTAAPKFSVP
ESVMKETLYPKYESVQASRLLTDKFSYKSSAIT--FRRHSRTNFWCFLSRKSASFENIQK
WFSAQPTQLRQVKSAVDLRKEDIIAPLEIKNDMQSSIKEVMFQKTKELKRQLQLTKQNKT
EEP-IPVKKNIDDIFDN-----MCEKHSLRNLSLTLIEASKKAGISYIVYPKKKKMKWK-
KRLKQQKLIFVYEELSKPPKSL--ERSTSHGILPEQKKYLFKVPLYERQIRCPSLPLYLN
FEKFFQTKGGIPEN------------IDPRTWAFDSLIADKDASTP-----VKE-----K
DDKISVPKDPPERVKEPPKL--KLSDDVESDLPQEVIKHYESEVKILTEEINDKTKYPAF

PF13181 // ENSGT00730000110941_0_Domain_0 (1021, 1050)

AYCRRGAIYRKLGKLQSAMNDLQRVMLLEPLFLNAYWQRHLIYLFQDKINEALDDLNYIH
KYNKNNTEAYLSKAEIYRGKKDVTMAILNYTQAIKCRPTDADIYFRRGEMYEIANKVLAI
DDFSKCIFYDPKRTDALLKRGLFYYENENWFAAIEDFTALLNIDHQNSQARTYRGIAYVK
RKFYKEATQDFSAAIHLDPNNWLALYYRGCLFRKSNPFRALQDYSVSALINDGYENLGCF
LHRGIVYAHLKLWLLAICDFETVISLERTTTLAYVNIGLIHLLYLDNYTEAIWQFSEAIR
IDPLYIQSYLCRAETY-FKLHKLKKAVNELSRAIHLQPDG-IQLYIRRGQYLLMMKCYDL
AKFTIYQVAEMDK---GLIEL--SPIQQALIYSFCENHDKAIEVLEGISWNRAEMTMYAL
LAKVQMKAKRTKE--AVKMLKKALDVISHSDKGPNTTAIS

PF00515 // ENSGT00730000110941_0_Domain_7 (1481, 1514)

ADCLYNLGLCYMEEGNLQMA
FDSFTKAVKANPDFAESFYQRGLCKVKLHKDSSILDFNRAITLNPKHYQ--AYLSRVAFY
GLKGRYSKAILNCNKAIKIYPESVRAYLYRGVLKYYNK-TYKLAITDLTTAISMDKNSYI
AFYNRALCYTKIRELQMALTDYGIVLLLDATETVKLNTFLNRGLIYLELDQYGFALEDFK
QAALISQTN--ESLCHATAMC----HHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSY
MECGHAEATKQAQKDFLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDIDPKN
YLAYEGRAVVCLQMGNNFAAMQDINAAVKINTT

PF13181 // ENSGT00730000110941_0_Domain_17 (1834, 1866)

AEFLTNRGVIHEFMGHKQNAMKDYQDA
ISLNPEYSLAYFNAGNIYFHHRQFSQASGYFSKALKFDPENEYILM-NRAITNT---ILK
KYEEAKGDFANVIESCPFW

PF00515 // ENSGT00730000110941_0_Domain_20 (1940, 1973)

AAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFR
AKVRCKIGLIEEAMADYNQALHLEDHNSVI

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AKFTIYQIAEMNK---GLIEL--SPIQQALIYSFCENHDKAMQVLDGITLSRPD

PF00515 // ENSGT00730000110941_0_Domain_6 (1435, 1470)

ITMCAL
LAKAQMKAKRNKE--AMRMFKKALDMFSH

ENSGT00730000110941_0_Linker_6_7 (1470, 1481)

SEKGPNAIEAS

PF00515 // ENSGT00730000110941_0_Domain_7 (1481, 1514)

ADCLYHLGLCYMEEGNLQMA
VDSFTKAVNANPDFAEGFYQRGLCKVKLHKDSSILDFNRAITLNPKH

PF00515 // ENSGT00730000110941_0_Domain_9 (1548, 1583)

YQ--AYLSRVAFY
GLKGRYSKAILNCNEAIKIYPRSVHAYICRGVLKYYNK-TYKLAITDLTTAINMSKTS

PF00515 // ENSGT00730000110941_0_Domain_11 (1619, 1652)

YI
AFYNRALCYTKISELRMALTDYGIVLLLDAG

ENSGT00730000110941_0_Linker_11_12 (1652, 1656)

ETVT

PF07719 // ENSGT00730000110941_0_Domain_12 (1656, 1689)

LNTLINRGLIYIELGQFSFALEDFK
QAALISKT

ENSGT00730000110941_0_Linker_12_14 (1689, 1692)

S--

PF00515 // ENSGT00730000110941_0_Domain_14 (1692, 1729)

VSLCQATAMC----YHRNKEFEEAVNFFTWALKIDPCFLDAYIGRGNSY
MEYGHEEATRQAQKDFVKALHFNPVCTKARIYLSYNLQAQEKFQKAWNHFTIAIDIDPKS
CLAYEGRAVVCLQMGDNFAAIQD-NAAIKINTTAEFLTNRGVIHEFMGQQQNAMRDYQAA
ISLNPTY

PF07719 // ENSGT00730000110941_0_Domain_17 (1868, 1901)

SLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENECATM-NRAIANT---ILK
KYEEAKEDFACVVESCPFW

PF00515 // ENSGT00730000110941_0_Domain_20 (1940, 1973)

AAVYFNRAYFYCCLKQYELAEEDLSKALSLKPNDALVYNFR
AEVRGKIGLIEEAMADYNQALDLQENTSVV

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-----------------------------------------------------MMESLEL
PEKTTEKSLHRTMSAPDLLTTEDSAILMVADDFESNMKVITIQKRQISEPEPEKPVESPP
EQP-VLSQTFLQFLHQRQSSHEPSSYKSESSENLALVEAARRAGVNYIIFPKRRRKKSK-
KKIVTEKLNAVYRTLSKPSRIL--QRSESISDQLGSRPLIPS----LHCHRTHSLPSALN
FNHFVQVRGGICKD------------DDVFSWVRNIWNDWFESTFPSITSSDEEK----E
TSVTPVEEVQPKEDKEPPQLTNELGDYLNPVLTEAEVAALETEVNRLTEEMEGQRAPSA

PF00515 // ENSGT00730000110941_0_Domain_0 (1020, 1050)

F
YYCRRGALNRKLGRLKEAMDDLQEAIYLEPLLLNAYWHRHFIYLFQEKDLEALNDLNYIL
KWNKNNAGVYLSKAEIFRNKGDITLAIMNYTQALKCKPTDDNIYFKRGEVYEKENKILSM
DDYSKCIFYNPRRTDALMKRGIYHFENSNWKAAIQDFTALLKIEPINAQARTYRGRAHTK
CAQNKEATEDFSSAIHLDPNNWLAFYHRGCLIRKSNPHKALQDFSVSVLINDGYENLGAF
LHRGILYTYLKMWTLAICDFQNVLDLDRGVSVAFINIGLIFFLHLSDNFEAIRQFSEAIK
VDPQGIRSYICRAEAY-HKMHNYKHAVRDISRAIHLCPDG-IKLYILRGFYLYQMKNYDL
AKFTIYQIAQMNK---GSFSW--SPIQESLVFSFCEDHAKAIEILYSVTLSKPVPTTFFL
LGKAQMKAHLFQQ--AMETFRHCLKILIHWEKNKYSELMA

PF00515 // ENSGT00730000110941_0_Domain_7 (1481, 1514)

AEIHFHLGLCYMEEACFETA
YETFSKAVKLNPEYAEAFYQRGLCRLHLQKDSCVQDFNRAITIDSQHFQ--AYLSRAAFY
GMKGRYSKAILNCNEAIRIYPESMRAFLYRGVLKYYNK-TYKLAVEDLTKTINLDKNCFI
AFYNRALCFHKMKEFQKALIDFGIVLLLDCGTDIIF

PF00515 // ENSGT00730000110941_0_Domain_12 (1657, 1689)

KSLINRGLIYAELGKHVYAMEDFI
EALQTNPTN--VYLHQAIAIC----HHRMQEFEKAVNSFTHVLQLDPFHLNAYVGRGNSF
LEYGHEDGNRQAQKDFLRALHLNPMCMKARISLGYNLQGQGKFQKAWNHFTIAMEINPTY
HLAYEGRAVVCLQMGDNFAALQDINAGLKLTTTAELLTVRGVIHQFMGFRHISMKDYQKA
ISLNPEYSL

PF00515 // ENSGT00730000110941_0_Domain_17 (1870, 1901)

AYFNAANIYFHNRQFSQANDYYSKALHFDPENESAAL-NRAITNM---LLN
KTEDAKADFERAIQLCPFS

PF00515 // ENSGT00730000110941_0_Domain_20 (1940, 1973)

AAVYFNRAHLFCTLKQYDLAEEDLSTALSLQPNDALAYKLR
SDVRGKMGLIKEAITDYKQALDLQEMSRPH

--------------------MSTIPRHFGLKYKEESYMFKELEKVRQETKKDFLRFKQKL
ASKPAVDERPVHSLYAPGAAR-------PERVSCAAART---SRGSPSAKGPAMSAAALL
QEVLGGAPRPSGLGEAAAPGKTLSFRPRDFYLRSSAFLRHQTLKKPPVIASGFGTARPVV
LLPPPEPPVKRRACRVLGSSRHAAPRPVLDLGRGREEGQEVAPLSGPCMAKERKVSS---
-ISTEDGYTDVSSGRRKVR----------IRTHFMSESRAREAR-------EAAGLGAQG
EQESLPPSDAREAAWQALLPARVIPTSIEEIIASLQSEAQLASDQTIKELIRSILGQNYD
IRMEDISLMG-KMYRKTSSMQ-AETPEIQAEHRFQMGAEE---SQTNMHKELPEAMSSIL
QIEQED-IEWGT-SEVESTVFKPQEILQVQPAEELSKP--LEDGQPT-SDSKEAKRVSLT
AKSSEFLQIEGKEVKQMQKRV-----SLRPRKSSKPLCDKKLREKIPRDYSMPHLHDLCA
TIPARELPIDLRLASRVYHTANRKGHNTLLGKFGTSFLDDHFTDEE-QADRILYGIPVMD
DNQEYVHIPLTPQGIPPELAQGTRERAHKPHLQVLGEEMCAYPEFTKLFWNTAAPKFSVP
ESVMKETLYPKYESVQASRLLTDKFSYKSSAIT--FRRHSRTNFWCFLSRKSASFENIQK
WFSAQPTQLRQVKSAVDLRKEDIIAPLEIKNDMQSSIKEVMFQKTKELKRQLQLTKQNKT
EEP-IPVKKNIDDIFDN-----MCEKHSLRNLSLTLIEASKKAGISYIVYPKKKKMKWK-
KRLKQQKLIFVYEELSKPPKSL--ERSTSHGILPEQKKYLFKVPLYERQIRCPSLPLYLN
FEKFFQTKGGIPEN------------IDPRTWAFDSLIADKDASTP-----VKE-----K
DDKISVPKDPPERVKEPPKL--KLSDDVESDLPQEVIKHYESEVKILTEEINDKTKYPAF

PF13181 // ENSGT00730000110941_0_Domain_0 (1021, 1050)

AYCRRGAIYRKLGKLQSAMNDLQRVMLLEPLFLNAYWQRHLIYLFQDKINEALDDLNYIH
KYNKNNTEAYLSKAEIYRGKKDVTMAILNYTQAIKCRPTDADIYFRRGEMYEIANKVLAI
DDFSKCIFYDPKRTDALLKRGLFYYENENWFAAIEDFTALLNIDHQNSQARTYRGIAYVK
RKFYKEATQDFSAAIHLDPNNWLALYYRGCLFRKSNPFRALQDYSVSALINDGYENLGCF
LHRGIVYAHLKLWLLAICDFETVISLERTTTLAYVNIGLIHLLYLDNYTEAIWQFSEAIR
IDPLYIQSYLCRAETY-FKLHKLKKAVNELSRAIHLQPDG-IQLYIRRGQYLLMMKCYDL
AKFTIYQVAEMDK---GLIEL--SPIQQALIYSFCENHDKAIEVLEGISWNRAEMTMYAL
LAKVQMKAKRTKE--AVKMLKKALDVISHSDKGPNTTAIS

PF00515 // ENSGT00730000110941_0_Domain_7 (1481, 1514)

ADCLYNLGLCYMEEGNLQMA
FDSFTKAVKANPDFAESFYQRGLCKVKLHKDSSILDFNRAITLNPKHYQ--AYLSRVAFY
GLKGRYSKAILNCNKAIKIYPESVRAYLYRGVLKYYNK-TYKLAITDLTTAISMDKNSYI
AFYNRALCYTKIRELQMALTDYGIVLLLDATETVKLNTFLNRGLIYLELDQYGFALEDFK
QAALISQTN--ESLCHATAMC----HHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSY
MECGHAEATKQAQKDFLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDIDPKN
YLAYEGRAVVCLQMGNNFAAMQDINAAVKINTT

PF13181 // ENSGT00730000110941_0_Domain_17 (1834, 1866)

AEFLTNRGVIHEFMGHKQNAMKDYQDA
ISLNPEYSLAYFNAGNIYFHHRQFSQASGYFSKALKFDPENEYILM-NRAITNT---ILK
KYEEAKGDFANVIESCPFW

PF00515 // ENSGT00730000110941_0_Domain_20 (1940, 1973)

AAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFR
AKVRCKIGLIEEAMADYNQALHLEDHNSVI

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-----------------------------------------------------RMRCYDL
AKFTIYQVAELNK---GLIEL--SPIQQALIYSFCENHDKAIQVLDGITLNKPDVPMCTL
LAKAQMKAKRNKE--AMRMFKKALDLISSSDKGLNPLAAS

PF00515 // ENSGT00730000110941_0_Domain_7 (1481, 1514)

ADCLYHLGLCYMEEGSLQLA
FDSFTKAVKANPDFAESFYHRGLCKVKLHKSGSILDFNRAITLDPKHYQ--AYLSRVAYY
GLKGRYSKAILSCNEAIKIYPQSVRAYVYRGVLKYYSR-NYKLAITDLTTAINMDKNSYI
AFYNRALCYTKINELQMALTDYGIVLLLNAGETVTLNTFINRGLIYAELEQFNFALEDFK
QAALISKTN--VSLCQATAVC----YHRNKEFEEAVNFFTWAVKIDPRFLDAYIGRGNSY
MEYGHDEATKQAQKDFLKALHFNPVYTKARICLGYNLQAQGKFQKAWNHFTIAMEVDPKS
YLAYEGRAVVCLQMGDNFAAFQDINAAIKINAT

PF00515 // ENSGT00730000110941_0_Domain_17 (1834, 1867)

AEFLTNRGVIHEFMGQQQNAMRDYQEA
ISLNPTYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENECATM-NRAIANT---VLK
RYEEAKEDFAYVVESCPLW

PF00515 // ENSGT00730000110941_0_Domain_20 (1940, 1973)

AAVYFNRAYFYCCLKQYELAEEDLSKALSLKPNDALIYNLR
AEVRGKIGLIEEAMADYNKALDLQEHASVV

--------------------MSMIPRHFGLKYKEESYMFKELEKVRQETKKDFLRFKQKL
ASKPAVGESPVHSLHAPGPAR-------PARVSCAAART---SRRYPPAKGPAMSAAALL
QEVLGGAPRPSGLGEAAAPGKTRSFRPRDFYLRSSAFLRHQALKKPPVIASGFGTARPVV
LLPPPEPPVKRRARGVLESSRHAAPRRVFDLGREREESQEVAPLAGPCMAKERKASS---
-VSAEDSYTEASSGRRKVR----------IRSNFVSESGAREAR-------EAAGLGAQG
EQESWPPSDAREAAWQALLPSRVIPTSIEEIIASLQSEAQLASDQTIKELIRSVLGQNYD
ITMEDISLMG-KMYLKTSPMQ-AETPEIQAEYKFQMGAEE---SQMSVHKELPETMSSIL
QIEQED-IEWGP-SEAESIVFKPQEISQVQPAEELSKP--LEDGQPT-SDSKEAKWVSLT
AKSPEFLQIEGKEIKRMWKRK-----SLRPRKSSKPLCDKKRHKKIPQDYSMPHLHDLCI
TIPAQELPVDLRLASRVYHTANRKGHDTLLGKFGTSFLDDRFTDEE-QTDRILYGIPVMD
DNQEYVHIPPTPQGIPPELAQGTRERAHKPHLEVLGEEMCAYPEFTKLFWNTAAPKFSVP
ESVMKETLYPKYESVQASRLLTDKFSYKSSVIT--LHQHSRTNFWCFLPRKSASFESIQK
WFSAQPTQLRRVKSSVDLRKEKIIAPLEMKNDMQSSIKEVMFQKAKELKHQLQLTKQNKT
EEP-NYVKENRDDIFDN-----MCEKHSLRNLSLTLIEASKKAGISYIVYPKKKKMRWK-
KRLKQQKLIFVYEELSKPPKSL--ERSASHGILPGQKKYLFKVPLYERQIRCPSLPLYLN
FEKFVQAKGGIPEN------------IDPRTWALDRLIEYKDASIP-----VKE-----K
DDKISVPKDLPERVKEPPKL--KLNDYVESDLPQEVIKYYESEVKILTEEINDKTKYPAF

PF13181 // ENSGT00730000110941_0_Domain_0 (1021, 1050)

AYCRRGAIYRKLGKLQSAMNDLQRVMLLE

ENSGT00730000110941_0_Linker_0_1 (1050, 1095)

PLFLNAYWHRHLIYLFQDKTNEALDDLNYIH
KYNKNNTEAYLSKA

PF13414 // ENSGT00730000110941_0_Domain_1 (1095, 1131)

EIYREKKDITLAILNYTQAIKCRPTDADIYFRRGEMYEITNKVLAI
DDFSKCIFYDPKRTDALLKRGLFYYENENWFAAIEDFTALLNIDHQNSQARTYRGIAYVK
RKFYKEATQDFSAAIHLDPNNWLALYYRGCLFRKSNPFRALQDYSVSALINDGYENLGCF
LHRGIVYAHLKLWLLAICDFETVISLERTITLAYVNIGLIHLLHLDNYTEAIWQFSEAIR
IDPLCIQSYLCRAETY-FKLHKLKKAVNELSRAIHLQPDG-IQLYIRRGQYLLMMKCYDL
AKFTIYQIAEMGK---GLSEL--SPMQQALIYSFCENHDKAIEVLDGISWNRAEMTMCAL
LAKVRMKAKRT-------------------------------------------------
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---------------------------KINEFEEAVNFFTWALKINPCFLDAYVGRGNSY
MEYGHDEATKQAQKDFLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKN
YLAYEGRAVVCLQMGNNFAAMQDINAAMKISTT

PF13181 // ENSGT00730000110941_0_Domain_17 (1834, 1866)

AEFLTNRGVIHEFMGHKQNAMKDYQDA
ISLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLM-NRAITNT---ILK
KYEEAKEDFANVIESCPFW

PF00515 // ENSGT00730000110941_0_Domain_20 (1940, 1973)

AAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFR
AKVRGKIGLIEEAMADYNQALDLEDYASVI

--------------------MSTIPRHFGLKYKEESYMFKELEKVRQETKKDFLRFKQKL
ASKPAVDERPVHSLYAPGAAR-------PERVSRSAART---SRGSPSAKGPAMSAAALL
QEVLGGAPRPSGLGEAAAPGKTLSFRPRDFYLRSSAFLRHQTLKKPPVIASGFGTARPVV
LLPTPEPPVKRRACRVLGSSRHAAPRPVLDLGRGREESQEVAPLSGPCMAKDRKVSS---
-ISTEDGYTDVSSGRRKVR----------IRTHFMSESRAREAR-------EAAGLGAQG
EQESLPPSDAREAAWQALLPARVIPTSIEEIIASLQSEAQLASDQTIKELIRSILGQNYD
IRMEDISLMG-KMYRKTSSMQ-AETPEIQAEHGFQMGAEE---SQTSMHKELPEAMSSIL
QIEQED-IEWGT-SEVESTVFKPQEISQVQPAEELSKP--LEDGQPT-SDSKEAKRVSLT
AKSSEFLQIEGKEVKQMQKRI-----SLRPRKSSKPLCDKKLREKIPRDYSMPHLHDLCT
TIPAQELPIDLRLASRVYHTANRKGHNTLLGKFGTSFLDDHFTDEE-QADRILYGIPVMD
DNQEYVHIPLTPQGIPPELAQGTRERAHKPHLQVLGEEMCAYPEFTKLFWNTAAPKFSVP
ESVMKETLYPKYESVQASRLLTDKFSYKSSAIT--FRRHSRTNFWYFLSRKSASFENIQK
WFGAQPTQLRQVKSAVDLRKEDIIAPLEIKNDMQSSIKEVMFQKTKELKRQLQLTKQNKT
EEP-IPVKKNIDDIFDN-----MCEKHSLRNLSLTLIEASKKAGISYIVYPKKKKMKWK-
KRLKQQKLIFVYQELSKPPKSL--ERSTSHGILPEQKKYLFKVPLYERQIRCPSLPLYLN
FEKFFQTKGGIPEN------------IDPRTWAFDRLIADKDASTP-----VKE-----K
DDKISVPKDPPERVKEPPKL--KLSDDVESDLPQEVIKHYESEVKILTEEINDKTKYPAF

PF13181 // ENSGT00730000110941_0_Domain_0 (1021, 1050)

AYCRRGAIYRKLGKLQSAMNDLQRVMLLEPLFLNAYWQRHLIYLFQDKINEALDDLNYIH
KYNKNNTEAYLSKAEIYRGKKDVTMAILNYTQAIKCRPTDADIYFRRGEMYEIANKVLAI
DDFSKCIFYDPKRTDALLKRGLFYYENENWFAAIEDFTALLNIDHQNSQARTYRGIAYVK
RKFYKEATQDFSAAIHLDPNNWLALYYRGCLFRKSNPFRALQDYSVSALINDGYENLGCF
LHRGIVYAHLKLWLLAICDFETVISLERTTTLAYVNIGLIHLLYLDNYTEAIWQFSEAIR
IDPLCIQSYLCRAETY-FKLHKLKKAVNELSRAIHLQPDG-IQLYIRRGQYLLMMKCYDL
AKFTIYQVAEMDK---GLIEL--SPIQQALIYSFCENHDKAIEVLEGISWNRAEMTMYAL
LAKVQMKAKRTKE--AVKMLKKALDVISHSDKGPNTTAIS

PF00515 // ENSGT00730000110941_0_Domain_7 (1481, 1514)

ADCLYNLGLCYMEEGNLQMA
FDSFTKAVKANPDFAESFYQRGLCKVKLHKDSSILDFNRAITLNPKHYQ--AYLSRVAFY
GLKGRYSKAILNCNKAIKIYPESVRAYLYRGVLKYYNK-TYKLAITDLTTAISMDKNSYI
AFYNRALCYTKIRELQMALTDYGIVLLLDATETVKLNTFLNRGLIYLELDQYGFALEDFK
QAALISQTN--ESLCHATAMC----HHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSY
MECGHAEATKQAQKDFLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDIDPKN
YLAYEGRAVVCLQMGNNFAAMQDINAAVKINTT

PF13181 // ENSGT00730000110941_0_Domain_17 (1834, 1866)

AEFLTNRGVIHEFMGHKQNAMKDYQDA
ISLNPKYSLAYFNAGNIYFHHRQFSQASGYFSKALKFDPENEYILM-NRAITNT---ILK
KYEEAKGDFANVIERCPFW

PF00515 // ENSGT00730000110941_0_Domain_20 (1940, 1973)

AAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFR
AKVRCKIGLIEEAMADYNQALHLEDHNSVI

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------------------MFKKALEVFSHSDKGPNAVAISV

PF00515 // ENSGT00730000110941_0_Domain_7 (1482, 1514)

DCLHNLGLCYMEEGNLQMA
FDCFTKAVKANPDFAEGFYQRGLCKVKLQRDNSILDFNRAIALNPKHYQ--AYLSRVAFY
GLKGRYSKAILNCNEAIKIYPQSVRAYLYRGVLKYYSK-NYKLAIRDLTIAVNMDKTSYA
AFYNRALCYTKIRELQMALIDFGIVLLLDAAETITLNTFINRGLIYTELEQYGFALEDFK
QAALISQTD--VSLCQAT

PF13181 // ENSGT00730000110941_0_Domain_14 (1699, 1727)

AMC----HHRIQEFKEAISFFTQALKINPLFLDAYIGRGNSY
MGYGHEA-TREAQKDFLKALRLNPLCTKARISLCYNLQVQGKLQKAWNHFTITIEVDPNC
YLAYEGRAVVCLQMGINFAAMQDINAAMKINTTAEFLTNRGVIHEFM

PF13414 // ENSGT00730000110941_0_Domain_17 (1848, 1879)

GQQQNAMKDYQAA
IALDPKYSLAYFNAGNIYFHHRQFSQASDYYSRSLKFDPENEYALM-NRAITNT---ILN
DYEEAKEDFACVIERCPFW

PF00515 // ENSGT00730000110941_0_Domain_20 (1940, 1973)

AAVYFNRAHLYCCLKRYDLAEEDLSRALSLKPTDVLVYDLR
AEVRGKMGLIEEAMADYNQALDLEECASVP