Query Results 

------------------------------------------------------------
------------------------------------------------------------
--MATLLSQPQRRPPLLRQAIKI-----------------RR-----R-----R--V-RD
LQDPLAPKAQEIEPPSHHLSPEERALLYEEALYTVLHRLGQPEPNHVREASELLRYLQEA
FHMEPEEHRQML-----QQAQKLEKPIFC

PF00168 // ENSGT00730000110939_1_Domain_0 (270, 380)

LKATVKQAKGILGKDVSGFSDPYCLLG-IEQ
GVGPQGGSPGS-RHRQKAVVRHTIPEEQTHRTQVITQTLNPVWEETFILEFEDINTSSFH
LDMWDMDTVESVRQKLGEL

ENSGT00730000110939_1_Linker_0_1 (380, 643)

TDLHG----------LRR--IFKEARKDKGQDDFLGNVVLR
-------------LQDLRCREDQWYRLEPCTETYPDRGQCHLQLQLIHKRR-APKASRSQ
PSYTVHLHLLQQLVSHEVTRHQAGSTSWDGSLSPQAATILFLHATQKDLSDFHQSMAAEG
FPYSRLYQSLEFPSSCLLHPITSIEYQWIQGRLKGEQLEELATSFSNLLAYGLSLIRKFR
SVFPLSVSDSPARLQSLLRVL--VQMCKMKAFGELCPDSPPL

PF06292 // ENSGT00730000110939_1_Domain_1 (643, 722)

PRLVTETLRTGTVEWF--
---HLKQQHHQPMVQGMLE---ALLSLVQDIIGDLHQCRHTWSKIFQNTLKIDLFSMAFL
ELQWLV----AKRVQDHTAAVVGSPVSPEMGESLFQLYVSLKELCQLGPVPA-------E
RDGVLALDGFH--RW-FQPAIPSWLQKTYSVALARVQRAVQMDELVPLGELTKHSTSA-V
DLSTCFAQISHTARQLDWPDPEEAFMITVKFVEVQ-RLLVSFPTFLDCRSWQTQPAPHPH
ARACLQ----LCVVVNDMEQLRL-IGKLPTQLAWEALEQRVGAVLEQGQLQNTLHAQLQG
ALAGLGH-EIRTGVRTLAEQLEAGIARHIQKLVGVKESVLPEDAI-LPLMKFLEVKLCYM
NTNLVQE---NFSSLLT--LLWTHTLTVLMEAAASHRSCPLASSRLKIALQNLEICFYAE
GCGLPPAALHTTTFQALQRDLELQAASSRELIQKYFCSRIQQQAETASEELGAVTVKASY
RASEQK

PF00168 // ENSGT00730000110939_1_Domain_4 (1147, 1252)

LRVELLSASSLLPLDSNGSSDPFVQLTLEPRHEFPELAPRETQKHKKDLH----
---------PLFDETFEFLVPAEPCQKDGACLLLTVLDHDTLGADDLEGEAFLPLRSVPG
LTGAEE-----PGEVPQTRLPLTYPALNG--------------------------DPILQ
LLESRKGDREAQVFVRLRRQRAKQASQH-----------------APR----P-------
------GR-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MATLLSHLQRRPPLVRQAIKI-----------------RR-----R-----R--V-RD
LQDPPAHGAQEIEPASHHLSPEERALLYEEALYTVLHRLGQPEPGHVRETSELLLYLREA
FHVEPEEHQEML-----QRVQKLEKPIFC

PF00168 // ENSGT00730000110939_1_Domain_0 (270, 379)

LKATVKQAKGILGKDVSGFSDPYCLLG-IEQ
GVSVQGGSPGS-RRRQKAVVRHTIPEEHTHRTQVIEQTLNPVWEETFILEFEDINSSSFH
LDMWDMDAVESVRQKLGELTDLHG----------LRR--IFKEARKDKGQDDFLGNIVVR
-------------LQDLRCREDHWYPLEPCTETYPDRGQCHLQFQFIHKRR-APAASRSQ
PSYTVHLHLLQQLVSHEVTRHQAGSTSWDGSLSPQAATILFLHATQKDLSDFHQSMA-QW
LAYSRLYQSLEFPSSCLLHPITSIEYQWIQGRLKGEQLEELAASFSSLLAYGLSLIRKFR
SVFPLSMADSPARLQSLLRVL--VQMCKMKAFGELCPDSAPLPRLVTETLRTGTTEWF--
---HLKQQHHQPMVQGLLEAGKALLSLVQDVIGDLLQCRHTWNKIFQNTLKVDLFSMAFV
ELQWLV----AKRVQDHTAAVAGSPVSPEMGESLFQLYVSLKELYQLRPGPT-------D
RDGVLALEGFH--RW-FQPAVPSWLQKTYSVALARVQRAVQMDELVPLGELTKHSTSA-V
DLSTCFAQISHTARQLDWPDPEEAFMITVKFVEDTCRLALVYCSLIKARARELSAGQKDQ
GQAANM----LCVVVNDMEQLRLVIGKLPAQLAWEALEQRVGAVLEQDQLQNTLHAQLQG
ALAGLGH-EIRTGVRTLAQQLEVGIATHIRKLVGVKESVLP

PF10540 // ENSGT00730000110939_1_Domain_3 (1002, 1115)

EDAI-LPLMKFLEVKLCYM
NTNLVQE---NFSSLLT--LLWTHTLKVLTDAAASQRSCPLASSRLKIALQNLEICFYAE
GCGLPPAALHTDDFQALQRDLELQAASSRELIRK

ENSGT00730000110939_1_Linker_3_4 (1115, 1147)

YFCSRIQRQAETTSEELGAVTVKASY
RASEQK

PF00168 // ENSGT00730000110939_1_Domain_4 (1147, 1251)

LRVELLSASSLLPLDSNGSSDPFVQLTLEPRHEFPELAPRETQKHKKDLH----
---------PLFDETFEFLVPAEPCLKDGACLLLTVLDHDTLGADDLEGEAFLPLRSVPG
LTGTEE-----PGEVPQTRLPLTYPALNG--------------------------DPVLQ
LLESRKGDREAQVFVRLRRQRAKQASQH-----------------APR----P-------
------GQ-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MATLLSHPQQRPPLLRQA----------------I-KIRR-----RRV--------RD
PQDPPPQMAPEIRPPSHHFSPEQRALLYEDALYTVLHRLGQPEPNHVTEASELLRYLQEA
FHVEPEEHQQM-L----QRVRELEKPIFC

PF00168 // ENSGT00730000110939_1_Domain_0 (270, 363)

LKATVKQAKGILGKDVSGFSDPYCLLGI-EQ
GVGVPGGSPGS-RQRQKAVVRHTIPEEETHRTQVITQTLNPVWDETFILEFEDITNASFH
LDM---------------------------------------------------------
----------------DHCREDQWYPLEPRTETYPDRGQCHLQFQLIHKRR-ATSASRSQ
PSYTVHLHLLQQLVSHEVTQHEAGSTSWDGSLSPQAATILFLHATQKDLSDFHQSMA-QW
LAYSRLYQSLEFPSSCLLHPITSIEYQWIQGRLKAEQEEELATSFSSLLTYGLSLIRRFR
SIFPLSVSDSPARLQSLLRVL--VQMCKMKAFGELCPNTAPLPQLVTEALQTGTTEWF--
---HLKQQHHQPMVQGILEAGKALLGLVQDVISDLHQCQRTWDKIFHNTLKIHLFSMAFR
ELQWLV----AKRVQDHTT-AVGDAVSPEMGESLFQLYISLKELCQLRLSSS-------E
RDGVLALDNFH--RW-FQPAIPSWLQKTYNEALARVQRAVQMDELVPLGELTKHSTSA-V
DLSTCFAQISHTARQLDWPDPAEAFMITVKFVEDTCRLALVYCSLIKARARELSSGQKDQ
GQAANM----LCVVVNDMEQLRLVIGKLPAQLAWEALEQRVGAVLEQGQLQNTLHAQLQS
ALAGLGH-EIRTGVRTLAEQLEVGIAKHIQKLVGVRESVLP

PF10540 // ENSGT00730000110939_1_Domain_2 (1002, 1056)

EDAI-LPLMKFLEVELCYM
NTNLVQE---NFSSLLT--LLWTHTLTVLVEAAASQRSSSLASNRLKIALQNLEICFHAE
GCGLPPEALHTATFQALQRDLELQAASSRELIRKYFCSRIQQQAETTSEELGAVTVKASY
RASEQK

PF00168 // ENSGT00730000110939_1_Domain_4 (1147, 1251)

LRLELLSASSLLPLDSNGSSDPFVQLTLEPRHEFPELAARETQKHKKDLH----
---------PLFDETFEFLVPAEPCRKAGACLLLTVLDYDTLGADDLEGEAFLPLREVPG
LSGSEE-----PGEVPQTRLPLTYPAPNG--------------------------DPILQ
LLEGRKGDREAQVFVRLRRHR--------AKQASQ--HALRPAP----------------
---------------------------------------

------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------MAAAGRAP
MGTLPREEESPEMDLSHRFSKQELALLYQEVLYTIQHRLGKPQPQHVADAQELCAYVQKA
FGMDAEEHRAIM-----QQVQELESPIFC

PF00168 // ENSGT00730000110939_1_Domain_0 (270, 436)

LKATVKEAKGILGKDVSGFSDPYCLLGIESK
NQEP---AHPDSKRRLKAVVKDLIPEDQIHRTQIISQTLNPVWDETFILEFEDMETASFH
LDMWDSDTVESVRHKLGELTDLHG----------LKR--IFKDARKDKGQDDFLGNVVLR
-------------LKDLHCWDDQWYQLEPRTETYPNRGQCHLQFLLTHKKR-ATTCSRTQ
PSYTVHRHLLQQLVSHEILQHQAGSTAWDGELSPHASTVLYLHATQKDLSDFHQVMA-QW
LAYSKLYQSLEFNSSCLLHQITSIEYQWVQERLRPEQKAELAESFQSLLTYGVSLIRRYR
IIFPLSVARSTERLQSLLRVL--VQMCKMKAFRELCTPSPDLPRMVSEALKSGTAEWF--
---HMKKQHLQPMVKSMEENGKALAKLLLEVIGDLQQCQKIWNKFFISTLKLNLFSIAYL
ELESLV----AEHVQEQLR-EIDTGMSKPTAESLFQLYLNLQELYRMKDFLP-------K
RDGPLALSDFH--QW-FKEAVPQWLQKAYSIALERAQRAVQMDQLTPFGEHNKHSTST-V
DLSTCYAQIVKTWQQLNWPDPEEAFMIMVKLVEDMCKIALMYCRLVKERAEALSLCEQNE
GEAANR----LCIVVNNIKQLRLLVLKLPWQLDWAQLEQRTGAVIDQQQIQHTLHHQLDS
TVSCLDR-EVQDVVQALATKLEAGIARHIQELSASNNAQEPEDSI-LPLMKFLESELQYL
NEHLVQE---NFKSLLA--LLWHHTLAVLTAAAGPQVP

PF10540 // ENSGT00730000110939_1_Domain_3 (1059, 1114)

SVQHCRKLHCALKSLELCFHAE
GCGLPLETLHSTAFLSLESRLALCSSTSRKLIQ

ENSGT00730000110939_1_Linker_3_4 (1114, 1146)

KYFSNRIQEQLDISSEKYGAVTIKALY
RPSEQ

PF00168 // ENSGT00730000110939_1_Domain_4 (1146, 1276)

KLRVEVLNAANLIPLDSNGSSDPFVQLTLEPRHEFPEVVARSTQCKRNELH----
---------PLFDEAFEFLIPPEKCRQDGACLLLTVFDYDTLGANDLEGEAFFPLRHLPG
LDADED--QPDTGWVPQTRLPLTHPKPGG--------------------------DEILR
LLECRKGDKEAQAFVKLRKQRAKQSKETA-------------------------------
---------------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MATLFSQTQRRPPLLRQAIKIRRRR-----------------------------RVRD
LPEVLPHRAQEIEPTSHHLSPEERALLYEEALYTVLYRLGQPEPTHVGESAELLRYLQEA
FRMEPQEHEQML-----RQVQELEKPIFC

PF00168 // ENSGT00730000110939_1_Domain_0 (270, 380)

LKATVKQAKGILGKDVSGFSDPYCLLGI-EQ
GVGVPGDSPGL-QWRQKAVVRHTIPDEQIHRTQVITQTLNPAWDETFILEFEDISNASFR
LDMWDMDTVESVRQKLGEL

ENSGT00730000110939_1_Linker_0_1 (380, 643)

TDLHG----------LRR--IFKEVRKDKGQDDFLGNVVLR
-------------LQDLRCREDQWYSLEPCTETYPDRGQCHLQFQFIHKRXXXXXXXX-X
XXXXXXXXXXXXXVSHEVTQHQAGSTSWNGLLSPQAATVLFLHSTQKDLSDFHQSMA-QW
LAYSRLYQSLEFPSSCLLYPITSIEYQWIQGRLKAEQLEELAASFSSLLAYGLSLIRRFR
SVFPLSVSDSPARLQSLLRVL--VQMCKMKAFGELCPERGPL

PF06292 // ENSGT00730000110939_1_Domain_1 (643, 722)

PRLVTEALQTGTTEWF--
---HLKQQHHQPMVQGMLEEGKALLNLVQDIIGDLHQCQRTWSKIFHNVLKIDLFSMAFL
ELQWLV----AKRVQDHIA-VVSGAVTPEMGESLFQLYISLKELYQLGPVLS-------E
RDGVLALEGFH--HW-FQPAVPSWLQKTYSVALERVQRAVQMDEXXXXXXXXXXXXXX-X
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXQ
GQAANM----LCVVVNDMEQLRLVIGKLPTQLAWEALEQRVGAVLEQGQLQNTLHAQLQG
ALAGLGH-EIRTGVRTLAEQLEVGIAKHIQKLVGLKESVLPEDAV-LPLMKFLEVELCYM
NTNLVQE---NFNXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXX-XXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXX

PF00168 // ENSGT00730000110939_1_Domain_4 (1147, 1252)

XXXXXXXXXXLLPLDSNGSSDPFVQLTLEPRHEFPELAPRESQKHKKELH----
---------PLFDETFEFLVPAEPCQKDGACLLLTVLDHDTLGADDLE-EAFLPLCSVPG
LTGTXX-----XXXXXXXXXXXXXXXXXX--------------------------DPILQ
LLESRKGDREAQVFVRLRRQRAKQASQHAPWPGR--------------------------
---------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------MATRLSDPQRLRRAIKI-----------------RR-----R-----G--A-RD
LPDARAQAAQEIKPPSHHFSREERDLLYEEALYTVLHRVGHPEPNHVIQASELLRYLQEA
FQVPPEEHEQIL-----QRVQELEKPIFC

PF00168 // ENSGT00730000110939_1_Domain_0 (270, 447)

LKATVKQAKGILGKDVSGFSDPYCLLGI-EQ
STGMPGGSPAA-RRRQKAVVRHTIPEEQTHHTRVINQTLNPVWEETFILEFNDIANASFH
LDMWDLDTVESVRQKLGELTDLHG----------LRR--IFKEARKDKGQDDFLGNVVLR
-------------LQDLHCKEDQWYPLEPCTETYPDRGQCHLQFQLIHKKR-ATVASRSQ
PSYTVHLHLLQQLVSHEVTQHQEGSTSWDASLSPQAATILFLHATQKDISDFHQSMA-QW
LAYSRLYQSLEFPSSCLLHPITSMEYQWVQGRLKAEQLEELAASFTSLLAYGLSLIRKFR
SVFPLSVADSPVRLQSLLRVL--VQMCKMKAFRELCPDSAPLPQLVTEALRTGTIEWF--
---HLKQQHHQPMVQGVLEAGKALLNLVQDITGDLHQCQRTWNKIFHNVLKIDFFPLAFL
ELQWLV----AKRVQDHTV-AVGSPVSPQMGESLFQLYVSLKELYQLGPDPSD------R
E-GVLPLDGFH--RW-FQPAIPSWLQKTYSVALERVQRAVQMDKLVPLGELTKHSTSA-V
DLSTCFAQISHTARQLDWPDPEEAFMITVKFVEDTCRLALVYCSLIKARARELSEGQKGQ
GQAANM----LCVVVNDMEQLRLVIGKLPTQLAWEALEQRVGAGLEQGQLQNTLHAQLQS
ALAGLDH-EIRTGVRTLAEQLEAGIAKQIQKLVGVRDSVLPE

PF10540 // ENSGT00730000110939_1_Domain_2 (1003, 1051)

DAI-LPLMRFLETELCYM
NTNLVQE---NFSSLLT--LLWTHTLTILVEVAASQRNSPLASNRLKVALQGLYACFHAR
GCGLPQEALHTATFQALQRDLELQAASTRELIQEYFCSRIQQQAETTSEELGAVTVKASY
RASEQ

PF00168 // ENSGT00730000110939_1_Domain_4 (1146, 1217)

KLRVELLSASNLLPLDSNGSSDPFVQLTLEPRHRFPELAPRETQKHKKDLH----
---------PLFDETFEL------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MATLLSHPQQRPPFLRQA----------------I-KIRR-----RRV--------RD
LQDPPPQMAPEIQPPSHHFSPEQRALLYEDALYTVLHRLGHPEPNHVTEASELLRYLQEA
FHVEPEEHQQT-L----QRVRELEKPIFC

PF00168 // ENSGT00730000110939_1_Domain_0 (270, 447)

LKATVKQAKGILGKDVSGFSDPYCLLGI-EQ
GVGVPGGSPGS-RHRQKAVVRHTIPEEETHRTQVITQTLNPVWDETFILEFEDITNASFH
LDMWDLDTVESVRQKLGELTDLHG----------LRR--IFKEARKDKGQDDFLGNVVLR
-------------LQDLRCREDQWYPLEPRTETYPDRGQCHLQFQLIHKRR-ATSASRSQ
PSYTVHLHLLQQLVSHEVTQHEAGSTSWDGSLSPQAATVLFLHATQKDLSDFHQSMA-QW
LAYSRLYQSLEFPSSCLLHPITSIEYQWIQGRLKAEQQEELAASFSSLLTYGLSLIRRFR
SVFPLSVSDSPARLQSLLRVL--VQMCKMKAFGELCPNTAPLPQLVTEALQTGTTEWF--
---HLKQQHHQPMVQGIPEAGKALLGLVQDVIGDLHQCQRTWDKIFHNTLKIHLFSMAFR
ELQWLV----AKRVQDHTT-VVGDVVSPEMGESLFQLYISLKELCQLRMSSS-------E
RDGVLALDNFH--RW-FQPAIPSWLQKTYNEALARVQRAVQMDELVPLGELTKHSTSA-V
DLSTCFAQISHTARQLDWPDPEEAFMITVKFVEDTCRLALVYCSLIKARARELSSGQKDQ
GQAANM----LCVVVNDMEQLRLVIGKLPAQLAWEALEQRVGAVLEQGQLQNTLHAQLQS
ALAGLGH-EIRTGVRTLAEQLEVGIAKHIQKLVGVRESVLPEDAI-LPLMKFLEVELCYM
NTNLVQE---NFSSLLT--LLWTHTLTVLVEAA

PF10540 // ENSGT00730000110939_1_Domain_3 (1054, 1114)

ASQRSSSLASNRLKIALQNLEICFHAE
GCGLPPKALHTATFQALQRDLELQAASSRELIR

ENSGT00730000110939_1_Linker_3_4 (1114, 1146)

KYFCSRIQQQAETTSEELGAVTVKASY
RASEQ

PF00168 // ENSGT00730000110939_1_Domain_4 (1146, 1260)

KLRVELLSASSLLPLDSNGSSDPFVQLTLEPRHEFPELAARETQKHKKDLH----
---------PLFDETFEFLVPAEPCRKAGACLLLTVLDYDTLGADDLEGEAFLPLREVPG
LSGSEE-----PGEVPQTRLPLTYPAPNG--------------------------DPILQ
LLEGRKGDREAQVFVRLRRHR--------AKQASQ--HALRPAP----------------
---------------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MATLLSHPQQRPPFLRQA----------------I-KIRR-----RRV--------RD
LQDPPPQMAPEIQPPSHHFSPEQRALLYEDALYTVLHRLGQPEPNHVTEASELLRYLQEA
FHVEPEEHQQT-L----QRVRELEKPIFC

PF00168 // ENSGT00730000110939_1_Domain_0 (270, 447)

LKATVKQAKGILGKDVSGFSDPYCLLGI-EQ
GVGVPGGSPGS-RQRQKAVVRHTIPEEETHRTQVITQTLNPVWDETFILEFEDITNASFH
LDMWDLDTVESVRQKLGELTDLHG----------LRR--IFKEARKDKGQDDFLGNVVLR
-------------LQDLRCREDQWYPLEPRTETYPDRGQCHLQFQLIHKRR-ATSASRSQ
PSYTVHLHLLQQLVSHEVTQHEAGSTSWDGSLSPQAATVLFLHATQKDLSDFHQSMA-QW
LAYSRLYQSLEFPSSCLLHPITSIEYQWIQGRLKAEQQEELAASFSSLLTYGLSLIRRFR
SVFPLSVSDSPARLQSLLRVL--VQMCKMKAFGELCPNTAPLPQLVTEALQTGTTEWF--
---HLKQQHHQPMVQGIPEAGKALLGLVQDVIGDLHQCQRTWDKIFHNTLKIHLFSMAFR
ELQWLV----AKRVQDHTT-AVGDAVSPEMGESLFQLYISLKELCQLRMSSS-------E
RDGVLALDNFH--RW-FQPAIPSWLQKTYNEALARVQRAVQMDELVPLGELTKHSTSA-V
DLSTCFAQISHTARQLDWPDPEEAFMITVKFVEDTCRLALVYCSLIKARARELSSGQKDQ
GQAANM----LCVVVNDMEQLRLVIGKLPAQLAWEALEQRVGAVLEQGQLQNTLHAQLQS
ALAGLGH-EIRTGVRTLAEQLEVGIAKHIQKLVGVRESVLPEDAI-LPLMKFLEVELCYM
NTNLVQE---NFSSLLT--LLWTHTLTVLVEAA

PF10540 // ENSGT00730000110939_1_Domain_3 (1054, 1114)

AAQRSSYLASNRLKIALQNLEICFHAE
GCGLPPEALHTAAFQALQRDLELQAASSRELIR

ENSGT00730000110939_1_Linker_3_4 (1114, 1146)

KYFCSRIQQQAETTSEELGAVTVKASY
RASEQ

PF00168 // ENSGT00730000110939_1_Domain_4 (1146, 1260)

KLRVELLSASSLLPLDSNGSSDPFVQLTLEPRHEFPELAARETQKHKKDLH----
---------PLFDETFEFLVPAEPCRKAGACLLLTVLDYDTLGADDLEGEAFLPLREVPG
LSGSEE-----PGEVPQTRLPLTYPAPNG--------------------------DPILQ
LLEGRKGDREAQVFVRLRRHR--------AKQASQ--HALRPAP----------------
---------------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MATSLSHSQRRPPLLRQAIKIRR----------------------RRV--------KD
LQEPLPQKAQEIEPPSHHFSPEERGLLYEEAVYTVLHG-GQPEPNHVTEGSELVRYVQEX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXXX-XX
XXXXXXXXXXX----XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXDLDTVESVRQKLGELTDLHG----------LRR--IFKEARKDKGQDDFLGNVVLR
-------------LQDLRCREDQWYPLEPCTETYPDRGQCHLQFQLIHKRR-ATVASRSQ
PSYTVHLRLLQQLVSHEVTQHQEGSTSWDGSLSPQAATVLFLHATQKDLSDFHQSMA-QW
LAYSRVYQSLEFPSSCLLHPITSIEYQWIQGRLKAEQLEELATSFRSLLAYGLSLIRRFR
AVFPLSVSDSPARLQSLLRVL--VQMCKMKAFGELCPNSAPL

PF06292 // ENSGT00730000110939_1_Domain_1 (643, 722)

PHLVTEALRTGTIEWF--
---HVKQQHHQPMVQGMLEEGKALLSLVQDIIADLHQCQRTWNKIFLNVLKINLFSTAFL
ELQWLV----AKKVQDYTVMVTGSPVTPDTGESLFQLYISLKELCQLGPVPS-------N
RDGVLALDSFH--RW-FQPAIPSWLQKTYSVALARVQRAVQMDQLVPQGELTKHSTSA-V
DLSTCFAQISHTARQLDWPDPEEAFMITVKFVEDTCRLALVYCSLIKARARELSAGQKDQ
GKAANM----LCVVVNDMEQLRLVIGKLPAQLAWEALEQRVGAVLEQGQLQNTLHAQLQG
ALAGLGH-EIRTGVRTLAEQLEVGIAKHIKKLVGLRESVLAEDAI-LPLMKFLEVELCYM
NSNLVQE---TYLL----TLLWTHTLTVLVEVAASQRSCPLASGRLKTALQSLEICFYAE
GCGLPPEALHTATFQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXX

PF00168 // ENSGT00730000110939_1_Domain_4 (1160, 1252)

XXXXXSSDPFVQLTLEPRHDFPELAPRETRKHKKDLH----
---------PLFDETFEFLVPAEPCQKDGACLLLTVLDHDRLGTNDLEGEAFLPLCSVQG
LTGTEE-----PSDVPQTRLPLTYPTLHG--------------------------DPILQ
LLESRKSDREAQVFVRLRRHRAKQASQHAPRLEQ--------------------------
---------------------------------------

------------------------------------------------------------
------------------------------------FCL---------------------
-----FLSHPTALPRGS-------------------------------NSGNCPKWHTAP
LWSPSPGAGRRKMDLSHRFSKQELALLYQEVLYTIRHRLGKPQPQHVADTQELCAYVQKA
FGMDAEEHRTIM-----QKVQELESPIFC

PF00168 // ENSGT00730000110939_1_Domain_0 (270, 380)

LKATVKEAKGILGKDVSGFSDPYCLLGIESK
SQEP---AHPDSKRRLKAVVKDLVPEDQIHRTQIISQTLNPVWDETFILEFEDMETASFY
LDMWDSDTVESVRHKLGELTDLHG----------LKR--IFKDARKDKGQDDFLGNVVLR
-------------LKDLHCWDDRWYHLEPRTETYPNRGQCHLQFLLTHKKR-ATTCSRMQ
PSYTVHRHLLQQLVSYEILQHQAGSTAWDGELSPHASTVLYLHATQKDLSDFHQVMA-QW
LAYSKLYQSLEFNCSCLLHQITSIEYQWVQERLRPEQKAELAESFQSLLTYGMSLIRRYR
IIFPPSVTRSTERLQSLLRVL--VQMCKMKAFRELCTLSPDLPKMVSEALKSGTTEWF--
---HMKKLHLQPTVTSMEENGKALAKFLLEVIGDLQQCDKIWNKFFISTLKLNLFSITYL
ELERLV----AEHVQEQLR-EVDTGMSKPAAESLFQLYLNLQELYRMKDFLP-------T
RDGPLALSDFH--QW-FKEAVPQWLQKAYSIALERTQRAVQMDQLTPFGEHNKHSTST-V
DLSTCYVQIVKTWQQLNWPDPEEAFMIMVKLVEDMCKIALMYCRLIKERAEALSLSKQNE
GEAANR----LCIVVNNIKQLRLLILKLPLQLDWAQLERRMGAVIDQQQIQHTLHHQLDS
TVCCLDR-EIQDVVQALATKLEAGIARHIQELSASNNAQEPEDSI-LPLMKFLESELQYL
NEHLVQE---NFKSLLA--LLWHHTLAVLTAAAGPQVPSVQHCRKLHCALKSLELCFHAE
GCGLPLETLHSTAFLSLESRLALCSSTSRKLIQKYFSNRIQEQLGISSEKYGAVTIKALY
RPSEQK

PF00168 // ENSGT00730000110939_1_Domain_4 (1147, 1252)

LRVEVLNAANLIPLDSNGSSDPFVQLTLEPRHEFPEVVARSTQCKRNELH----
---------PLFDEAFEFLIPSEKCRQDGACLL--VFDYDTLGSNDLEGEAFFPLCHVPG
LDAXRV--SSPTP-------HCSPLLPTG--------------------------DEILQ
LLECRKGDKEAQAFVRLRKQRAKQSKETA-------------------------------
---------------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MTTPGPQPLRRLPLLRQAIKIRRQRAK-----------------------------GL
Q-ETLPQTDQEMETPSHHFSPEEQALLYEEALYTVLHRVGRPEPKHVAEAAELLSYLQEA
FHMKPEIHQQLL-----QKVQDLEKPLFC

PF00168 // ENSGT00730000110939_1_Domain_0 (270, 379)

LKVTVKQAKGILGKDVSGYSDPYCLLGIIEQ
GVGTTEDSSGSHRRRQKAVVKNTIPEDQTHRTQVISQTLSPVWDETFFLEFEDISSANFH
LDMWDADQVESVRQKLGELTDLHG----------LRR--IFKEARKDKGQDDFLGNVVLK
-------------LQDLRCREDQWYPLEPRTETYPDRGQCHLQFLLIHKRR-ATTASRTH
PSYTVHRHLLQQLVSHEVTQHQAGSTSWDGELSPQASTILFLHATQKDLSEFHQSMA-QW
LAYSRLYQSLEFPGSCLLHPITAIEYQWIQGRLNPEQREELAASFNSLLTYGLSLIRRFR
SIFPLSASGSPARLQSLLRVL--IQMCKMKAFGELCPDGAPLSSLVAEVLRTGTLEWF--
---HLKQQHHQPMVQDMQEMGKAVLSLVLDVTGDLQQCQRTWNKIFSNTLKIDLFSMAFL
ELQKLV----AQRVEEHLA-AVGSVVSPEMGESLFQLYLSLKELYQLVPPPP-------E
RDRSLDLDGFH--KW-FLPAIPAWLLKTYSVALARLQRAVQMDQLVPLGELIKHSTSA-V
DLSTCFAQISHTARQLAWPDPEVAFMITVKFVEDTCKLALVYCSLIKARAKELSVNQ-DQ
AQAANM----LCVVVNDMEQLRLVVLRLPTQLSWQDLEQWAGAVLEPEQLQHTLHAQLQG
ALAGLDH-EIRSGVRTLAEQLEAGISRHIQRIVS--ESAVP

PF10540 // ENSGT00730000110939_1_Domain_3 (1002, 1115)

EDAI-LPLMRFLESELHYM
NRNLVQE---NFNSLLS--LLWTHTLSVLTQTAAAQRSSPVTSLKLKTALQNLEFCFYAE
GCGLSPEALHIPLLQDLQRKLELQASSSQELIQR

ENSGT00730000110939_1_Linker_3_4 (1115, 1147)

YFSNRIQQQADTSSEEFGAITIKASY
RLSEQK

PF00168 // ENSGT00730000110939_1_Domain_4 (1147, 1251)

LRIEVLSASNLLPLDSN--RDPFVQLTLEPRHEFTEVAPRETQKFKKELH----
---------PLFDEAFEFLVSPESCQKEGNCLLLTVLDHDTLGKDDLEGEAFLPLSAVLQ
LSGDNQ-----PGQVPQTRLPLTYPASNG--------------------------DPILQ
LLDIRKSDREAQAFVKLRRQRAKQAERLGQYPAP--------------------------
---------------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MATLLSNPQRRPPLLRQAIKI-----------------RR-----R-----R--V-RD
LQDPLPQMEPTCQPPSHHLSPEERALLYEEALYTVLHRLGQPEPTHVTEASELLQYLQEA
FHMEPEEHQKTL-----QRVRELQKPIFC

PF00168 // ENSGT00730000110939_1_Domain_0 (270, 379)

LKATVKQAKGILGKDVSGFSDPYCLLG-IEQ
GVGVPGGSPGA-RRRQKAVVRHTIPEDQTHRTQVISQTLNPVWDETFILEFEDITNANFH
LDMWDLDTVESVRQKLGELTDLHG----------LRR--IFKEARKDKGQDDFLGNVVLR
-------------LQDLRCREDQWYPLEPCTETYPDRGQCHLQFQLIHKRR-ATAASRSQ
PSYTVHLHLLQQLVSHEVTQHQTGSTSWDGSLSPQATTILFLHAMQKDLSDFHQSMA-QW
LAYSCLYQSLEFPSGCLLHPITSIEYQWIQGRLKAEQREELATSFQSLLAYGLSLIRRFR
SVFPLSVSDSPARLQSLLRVL--VQMCKMKAFRELCPDSAPLSQLVTEALRTGTVEWF--
---HLKQQHHQPMVQGMLEAGKALLSLVQDIVGDLQQCQRTWNKIFLNALKIDLFSAAFL
ELQWLV----AKRAKDHTA-AVGSPVSPEMGESLFQLYISLKELCQLHPAPL-------E
RDGVLALDGFH--CW-FQPAIPSWLQKTYSVALARVQRAVQMDQLVPLGELTKHSTSA-V
DLSTCFAQISHTARQLDWPDPEEAFMITVKFVEDTCRLALVYCSLIKTRARELSAGQKDQ
AQAANM----LCVVVNDMEQLRLVIGKLPTQLSWETLEQRVGAVLEQGQLQNTLHAQLQG
ALAGLSH-EIRTGVRTLAEQLEVGIAKHIQKLVGVRESVPP

PF10540 // ENSGT00730000110939_1_Domain_3 (1002, 1115)

EDAI-LPLMKFLEVELCYM
NTNLVQE---NFSSLLT--LLWTHTLTVLVEVAASQRSSCLASSRLKIALQNLEICFHAE
GCGLPLKALYTTTFQALQRDLELQAASSRELIQR

ENSGT00730000110939_1_Linker_3_4 (1115, 1147)

YFCSRIQQQEETTSEELGAVTVKASY
RASEQK

PF00168 // ENSGT00730000110939_1_Domain_4 (1147, 1251)

LRVELLSASSLLPLDSNGSSDPFVQLTLEPRHEFPELAARETQKHKKDLH----
---------PLFDETFEFLVSAEPCRKAGACLLLTVLDHDTLGADDLEGEAFLPLCEVPG
VTGSEE-----PGEVPQTRLPLTYPTPNG--------------------------DPILQ
LLESRKGDREAQAFVRLRRQRAKQ------------------------------------
---------------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MATLLSRPQRRPPLLRQAIKI-----------------RR-----R-----R--V-RD
PQDPIPQKE--IEPPSHQLSPEERTLLYEEAVYTVLHRLGQPEPNHVIEASELLRYLQEA
FHTEPEEHQRML-----QRVRDLQKPIFC

PF00168 // ENSGT00730000110939_1_Domain_0 (270, 447)

LKATVKQAKGILGKDVSGFSDPYCLLG-IEQ
GVGVPGDSPGA-RRRQKAVVRHTIPEEQTHRTQVISQTLNPVWDETFILEFEDITNASFH
LDMWDLDTVESVRQKLGELTDLHG----------LRR--IFKEARKDKGQDDFLGNVVLR
-------------LQDLRCREDQWYPLEPCTETYPDRGQCHLQFQLIHKRR-ATAASRSQ
PSYTVHLHLLQQLVSHEVTQHQAGSTSWDGSLSPQAATILFLHATQKDLSDFHQSMA-QW
LAYSRLYQSLEFPSGCLLHPITSIEYQWIQGRLKAEQREELAASFSSLLAYGLSLIRRFR
SVFPLSVSDSPVRLQSLLRVL--VQMCKMKAFGELCPDSAPLSQLVTEALNPVLT-----
-----------------------ASFLIQDIVGDLHQCKHTWNKIFQNALKIDLFSTAFL
ELQWLV----AKRVKDHTV-AVGSPVSPEVGESLFQLYVSLKELCQLHAVPS-------E
RDGVLALDGFH--RW-FQPAIPSWLQKTYSVALARVQRAVQMDQLVPLGELTKHSTSA-V
DLSTCFAQISHTARQLDWPDPEEAFMITVKFVEDTCRLALVYCSLIKARARELSAGQKDQ
GQAANM----LCVVVNDMEQLRLVIGKLPTQLAWEALEQRVGAVLEQGQLRNTLHAQLQG
ALAGLGH-EIRTGVRTLAEQLEVGIAKYIQKLVGVRESVSPEDAI-LPLMKFLEVKLCYM
NTNLVQE---NFSSLLT--LLWTHTVTELAEA

PF10540 // ENSGT00730000110939_1_Domain_3 (1053, 1112)

AASQRSSPLASSRLKIALQNLEICFHAE
GCGLLPEALHTATFQALQRDLELQAASSREL

ENSGT00730000110939_1_Linker_3_4 (1112, 1146)

ICKYFCSRIQQQAETTTEELGAVTVKASY
RASEQ

PF00168 // ENSGT00730000110939_1_Domain_4 (1146, 1258)

KLRVELLSASSLLPLDSNGSSDPFVQLTLEPRHEFPELAARETQKHKKDLH----
---------PLFDETFEFLVSAEPCRKAGACLLLTVLDHDTLGADDLEGEAFLPLCDLPG
LTGPEE-----PGEVPQTRLPLTYPAPNG--------------------------DPILQ
LLESRKGDREAQVFVRLRRQRANCSGGPP-------------AICLPACLFRPLAGGGGG
GGSLGPGLQAQSLLRE--GERTLPN----MSW--GGVHY

------------------------------------------------------------
------------------------------------------------------------
--MATLLSHPQQRPPFLRQA----------------I-KIRR-----RRV--------RD
LQDPPPQMAPEIQPPSHHFSPEQRALLYEDALYTVLHRLGQPEPNHVTEASELLRYLQEA
FHVEPKEHQQT-L----QRVRELEKPIFC

PF00168 // ENSGT00730000110939_1_Domain_0 (270, 447)

LKATVKQAKGILGKDVSGFSDPYCLLGI-EQ
GVGVPGGSPGS-RQRQKAVVRHTIPEEETHRTQVITQTLNPVWDETFILEFEDITNASFH
LDMWDLDTVESVRQKLGELTDLHG----------LRR--IFKEARKDKGQDDFLGNVVLR
-------------LQDLRCREDQWYPLEPRTETYPDRGQCHLQFQLIHKRR-ATSASRSQ
PSYTVHLHLLQQLVSHEVTQHEAGSTSWDGSLSPQAATVLFLHATQKDLSDFHQSMA-QW
LAYSRLYQSLEFPSSCLLHPITSIEYQWIQGRLKAEQQEELAASFSSLLTYGLSLIRRFR
SVFPLSVSDSPARLQSLLRVL--VQMCKMKAFGELCPNTAPLPQLVTEALQTGTTEWF--
---HLKQQHHQPMVQGIPEAGKALLGLVQDVIGDLHQCQRTWDKIFHNTLKIHLFSMAFR
ELQWLV----AKRVQDHTT-AVGDAVSPEMGESLFQLYISLKELYQLRMSSS-------E
RDGVLALDNFH--RW-FQPAIPSWLQKTYNEALARVQRAVQMDELVPLGELTKHSTSA-V
DLSTCFAQISHTARQLDWPDPEEAFMITVKFVEDTCRLALVYCSLIKARARELSSGQKDQ
GQAANM----LCVVVNDMEQLRLVIGKLPAQLAWEALEQRVGAVLEQGQLQNTLHAQLQS
ALAGLGH-EIRTGVRTLAEQLEVGIAKHIQKLVGVRESVLPEDAI-LPLMKFLEVELCYM
NTNLVQE---NFSSLLT--LLWTHTLTVLVEAA

PF10540 // ENSGT00730000110939_1_Domain_3 (1054, 1114)

ASQRSSSLASNRLKIALQNLEICFHAE
GCGLPPEALHTATFQALQRDLELQAASSRELIR

ENSGT00730000110939_1_Linker_3_4 (1114, 1146)

KYFCSRIQQQAETTSEELGAVTVKASY
RASEQ

PF00168 // ENSGT00730000110939_1_Domain_4 (1146, 1260)

KLRVELLSASSLLPLDSNGSSDPFVQLTLEPRHEFPELAARETQKHKKDLH----
---------PLFDETFEFLVPAEPCRKAGACLLLTVLDYDTLGADDLEGEAFLPLREVPG
LSGSEE-----PGEVPQTRLPLTYPAPNG--------------------------DPILQ
LLEGRKGDREAQVFVRLRRHR--------TKQASQ--HALRPAP----------------
---------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------AYVQKA
FGMDAEEHRVSM-----QRVKELESPIFC

PF00168 // ENSGT00730000110939_1_Domain_0 (270, 380)

LKATVKEAKGILGKDVSGFSDPYCLLGIEAK
SQEP---AHPDSKKRLKAVVKDLIPEDQIHRTQVISQTLNPVWDETFILEFEDTETASFH
LDMWDSDMVESVRHKLGEL

ENSGT00730000110939_1_Linker_0_1 (380, 643)

TDLLAVGTSPRSLYLLFR--IFKDARKDKGQDDFLGNVVLR
-------------LKDLHCWDDQWYQLEPRTETYPNRGQCHLQFLLTHKRR-ATTSSRTQ
PSYTVHRHLLQQLVSYEILQHQV--PWWDGELSRHASTVLYLHATQKDLSDFHQVMA-QW
LAYSKLYQSLEFNSNCLLHQITSIEYQWVQERLRPEQKAELAESFQSLLTYGVSLIRRYR
IIFPLSVARSTERLQSLLRVL--VQMCKMKAFRELCTLSPDL

PF06292 // ENSGT00730000110939_1_Domain_1 (643, 733)

PKMVSEALKSGTTEWF--
---HMKKQHLKPMVKSMEENGKALAKLLLEVIADLQQCQKTWNKFFISTLKLNLFSIAYV
ELESLV----AEHVQEQLH-EVDSSMSKPTAESLFQLYLNLQELYRMKDFLP-------E
RDGPLALSDFH--QW-FKEAVPQWLQKAYTIALERAQRAVQMDQLTPFGEHNKHSTST-V
DLSTCYAQIVKTWQQLNWPDPEEAFMIMVKLVEDMCKIALMYCRLIKTRAEALSLSEQNE
GEAANR----LCIVVNNIKQLRLLILKLPSQLDWAQLERRTGAVIDDGWAGCVLEDAV--
--GLLGGKKPQMSTRPRKGQLEAGIARHIQELSASNDTREPEDVS-AGVGQFPASALDIP
QVPLLTVPFPRPRSLLA--LLWHHTLAVLTAAAGPQTSSTQRYKKLQCALKVQPGAVHAE
GCGLPLETLHSAAFV-LESHLALCSSTSRKLIQKYFSNRIQEQLDASSEKYGAVTIKALY
RPSEQK

PF00168 // ENSGT00730000110939_1_Domain_4 (1147, 1252)

LRVEVLNAVNLIPLDSNGSSDPFVQLTLEPRHEFPEVVARTTQCKRNELH----
---------PLFDEAFDLYSPPQKCRQEGACLLLTVFDYDTLGANDLEGEAFFSPLSPR-
-------------RPPLM--------SVPS---------------------CASGDEILR
LLESRKGDKEAQAFVKLRKQRAKQSKETA-------------------------------
---------------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MATRLFHPQRRPPLLRQAIKI-----------------RR-----R-----N--V-QD
LQDPLAQMTKEVNPASYHFSPQERDLLYEEALYTVLHRLGRPEPSHVVEASELLQYLQEA
FQVQPEEHKRML-----QQARELEKPVFC

PF00168 // ENSGT00730000110939_1_Domain_0 (270, 447)

LKATVKQAKGILGKDVSGFSDPYCLLGI-EQ
GVGMPGGSPGS-RRRQKAVVRHTIPEEQTHRTQVINQTLNPVWDETFILEFEDITNASFH
LDMWDMDTVESVRQKLGELTDLHG----------LRR--IFKEARKDKGQDDFLGNVVLR
-------------LQDLRCRDDQWYPLEPRTETYPDRGQCHLQFQLIHKRR-ATVASRSQ
PSYTVHLHLLQQLVSHEVTLHKVGSTSWDGLLSPPATTILFLHATQKDLSDFHQSMA-QW
LAYSRLYQSLEFPSSCLLHPITSIEYQWIQGRLKAEQLEELTISFTSLLAYGLSLIRKFR
SVFPLSVSDSPARLQSLLRVL--VQMCKMKAFGELCQDTAPLPQLVTEALRNGTVEWF--
---HLKQQHHQPMVQGMLEAGKALLSLVQDVLGDLHQCQRTWNKIFHNALKIDLFSVAFL
ELQWLV----AKRVQDHTS-AVGSPVSPEMGESLFQLYISLKELCQLGPVPLD------R
D-GVLALDGFH--HW-FQPAIPSWLQKTYSVALERVQRAVQMDELVPLGELTKHSTSA-V
DLSTCFAQISHTARQLDWPDPEEAFMITVKFVEDTCRLALVYCSLIKARARALSAGQKDQ
GQAADM----LCVVVNDMEQLRLVIGKLPTQLAWEALEQRVGTVLDQGQLQNTLHTQLQS
ALAGLGH-EIRTGVQTLAEQLEVGIARHIQKLVDVKESVLPE

PF10540 // ENSGT00730000110939_1_Domain_2 (1003, 1052)

DAI-LPLMKFLEVKLCYM
NTNLVQE---NFSSLLT--LLWTHTLTVLVEVAASQRSSTLASGRLKVALQNLKICFHAE
GCGLPPEALHTATFQALQRDLELQAASSRELIQKYFCSRIQQQGETTSEQLGAVTVKASY
RSSEQ

PF00168 // ENSGT00730000110939_1_Domain_4 (1146, 1257)

KLHVELLSASSLLPLDSNGSSDPFVQLTLEPRHEFPELAPRETQKHKKDLH----
---------PLFDETFEFLVPAEPCRKDGACLLLTVLDHDTLGTNDLQGEAFLPLCTVPG
LSGCEE-----PGEAPQTRLPLTYPMPNG--------------------------DPILQ
LLESRKGDREAQAFVRLRRQRAKQASQH---------------------APRPGQ-----
---------------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MATPLSHPQQRPPLLRQA----------------I-KIRR-----RRV--------KD
LQDPLPQTAPEIQPPSHHFSPEQRALLYEDTLYTVLHRLGQPEPNHVTEASELLRYLQEA
FHVEPEEHQQAL-----QRVRELEKPTFC

PF00168 // ENSGT00730000110939_1_Domain_0 (270, 447)

LKATVKQAKGILGKDVSGFSDPYCLLGI-EQ
GVGAPGGSPGS-RRRQKAVVKHTIPEEQTHRTQVVTQTLNPVWDETFILEFEDITNSSFH
LDMWDLDTVESVRQKLGELTDLHG----------LRR--IFKEARKDKGQDDFLGNVVLR
-------------LQDLRCREDQWYPLEPRTETYPDRGQCHLQFQLIHKRR-ATLASRSQ
PSYTVHLHLLQQLVSHEVTQHQAGSTSWDGSLSPQAATVLFLHATQKDLSDFHQSMA-QW
LAYSRLNQSLEFPSSCLLHPITSIEYQWIQGRLKAEQEEELAASFSSLLAYGLSLIQRFR
SIFPLSVSDSPARLQSLLRVL--VQMCKMKAFGELCPNTAPLPQLVAEALQTGTTEWF--
---HLKQQHHQPMMQGMLEAGKALLGLVQDIVGDLHQCQRTWDKIFHNTLKIHLFPMAFR
ELQWLV----AKRVQDHTT-AVGDAVSPEMGESLFQLYISLKELCQLRPSSS-------E
RDGVMALESFH--RW-FQPAIPSWLQKTYSVALARVQRAVQMDELVPLGELTKHSTSA-V
DLSTCFAQISHTARQLDWPDPEEAFMITVKFVEDTCRLALVYCSLIKARARELSSGQKDQ
AQAANM----LCVVVNDMEQLRLVIGKLPAQLAWEALEQRVGAVLEQGQLQNTLHAQLQS
ALAGLGH-EIRTGVHTLAEQLEVGIAKHIQKLVGVRESVLPEDAI-LPLMKFLEVELCYM
NTNLVQE---NFSA----------------------------------------------
----------------LQRDLELQAASSRELIRRYFCGRIQQQAETISEELGAVTVKASY
RTSEQ

PF00168 // ENSGT00730000110939_1_Domain_4 (1146, 1260)

KLRVELLSASSLLPLDSNGSSDPFVQLTLEPRHEFPELAARETQKHKKDLH----
---------PLFDETFEFLVPDEPCRKPGACLLLTVLDYDTLGADDLEGEAFLPLCEVHG
LSGSEE-----PGEVPQTRLPLTYPAPNG--------------------------DPILQ
LLEGRKGDREAQVFVRL-RR--QRAKQGIR------------PFISWPFLFQPL---GWG
PGSLGAGLQAQSLLG--KGQGTLPKMRLQLPWGEGGDHY

------------------------------------------------------------
------------------------------------------------------------
--MATLLSNPQRRPPLLRQAIKI-----------------RR-----R-----R--V-RD
LQDPLPQKE--IEPPSHQLSPEERTLLYEEALYTVLHRLGQPEPNHVIEASELLRYLQEA
FHAEPEEHQRTL-----QRVRELQKPIFC

PF00168 // ENSGT00730000110939_1_Domain_0 (270, 447)

LKATVKQAKGILGKDVSGFSDPYCLLG-IEQ
GVGVPGDSPGA-RRRQKAVVRHTIPEEQTHRTQVINQTLNPVWDETFILEFEDIANASFH
LDMWDLDTVESVRQKLGELTDLHG----------LRR--IFKEARKDKGQDDFLGNVVLR
-------------LQDLRCREDQWYSLEPCTETYPDRGQCHLQFQLIHKRR-ATAASRSQ
PSYTVHLHLLQQLVSHEVTQHQAGSTSWDGSLSPQAATILFLHATQKDLSDFHQSMA-QW
LAYSRLYQSLEFPSGCLLHPITSIEYQWIQGRLKAEQREELASSFRSLLAYGLSLTRRFR
SVFPLSVSDSPARLQSLLRVL--VQMCKMKAFGELCPDSAPLSQLVTEALRTGTIEWF--
---HLKQQHHQPMVQGMLEAGKALLSLVQDIVGDLQQCQHTWNKIFHNVLKIDLFSLAFL
ELQWLV----AKRVKDHMA-AAGSPMSPEVGESLFQLYVSLKDLCQLQAVLS-------Q
RDGVLALDGFH--CW-FQPAIPSWLQKTYSVALARVQRAVQMDQLVPLGELTKHSTSA-V
DLSTCFAQISHTARQLDWPDPEEAFMITVKFVEDTCRLALVYCSLIKARARELSAGQKDQ
GQAANM----LCVVVNDMEQLRLVIGKLPTQLAWEALEQRVGAVLEQGQLQNTLHAQLQG
ALAGLGH-EIRIGVRTLAEQLEVGIAKHIQKLVDVKESVPPEDAI-LPLMKFLEVKLCYM
NTNLVQE---NFSSLLT--LLWTHTLTELAEA

PF10540 // ENSGT00730000110939_1_Domain_3 (1053, 1114)

AASQRSSPLASSRLKTALQNLEICFHAE
GCGLLPEALHTATFQALQRDLELQAASSRELIR

ENSGT00730000110939_1_Linker_3_4 (1114, 1146)

KYFCSRIQQQAETTSEELGAVTVKASY
RASEQ

PF00168 // ENSGT00730000110939_1_Domain_4 (1146, 1260)

KLHVELLSASSLLPLDSNGSSDPFVQLTLEPRHEFPELAARETQKHKKDLH----
---------PLFDETFEFLVSAESCQKAGACLLLTVLDHDTLGADDLEGEAFLPLCDLPG
LTGSEE-----TGEVPQTRLPLTYPTPNG--------------------------DPILQ
LLDSRKGDREAQVFVRLRRQRAKQASQHA-------------PR----------PGR---
---------------------------------------

MKFWPLGPSPARPWAKPLGQPRGPAL-CPVPCA-LC---------SVSRAQGPGLSEP--
----------PPAGKLTPPPAAQARAPGGRGA------AHRGVGCLGPAGQPLGLPAPPR
LPLSCWASLPPLGPPDKQSCFLWGRKGGGGVGARAGVGQLRRMDGSHGRPGDEE--AGPG
AGPPGDLPGDQIKPPSHHLSPEERARLYEEALYTVLHRLGRPEPSHVSEASELLRYLQQA
FLLEPEEHQQLL-----QRVRELERPIFC

PF00168 // ENSGT00730000110939_1_Domain_0 (270, 379)

LKATVKQAKGILGKDVSGFSDPYCLLGI-EQ
GAGVPGGSPGA-RRRQKAVVRHTIPEEQTHRTRVVAQTLSPVWDETFILEFEDISSASFH
LDMWDLDMAESVRHKLGELTDLHG----------LRR--ILKEVRKDKGQDDFLGNVVLR
-------------LQDLRCQEDQWYPLEPCTETYPDRGQCHLQFQLIHKRR-ATAASRSQ
PSYTVHLHLLQQFVSYEVTQHQTGSTSWDGSLSPQAATILFLHATQKDLSDFHQSMA-QW
LAYSRLYQSLEFPSNCLLHPITSIEYQWIQGRLKEEQLEELAASFGSLLAYGLSLIRKFR
SVFPLSVSDSPARLQSLLRVL--AQMCKMKAFGQLCPDSAPLPHLVTEALQTGTVEWF--
---HVKQQHYQPMVQGLLESGKALLSLVQDIIGDLHQCLHTWGKIFQNVLKIDLFSTAFL
ELQWLV----AKRVQEHTA-AVGGSVSPEMGESLFQLYVSLKELCRLGPAPS-------E
R--VLALDGFH--RW-FQPAIPSWLQKTYSEALARVQRAVQMDKLVPLGELTKHSTSA-V
DLSTCFAQISHTARQLDWPDSEEAFMITVKFVEDTCRLALVYCSLVKARARELSADQKDQ
GQAANM----LCVVVNNMEQLRLVIGKLPTQLAWEALEQRVGAVLEPGQLQNTLHAQLQG
ALAGLGH-EIRTGVRTLAEQLEVGIATHIQKLVGVRASVLP

PF10540 // ENSGT00730000110939_1_Domain_3 (1002, 1115)

EDAI-LPLMKFLEVELCYM
NTNLVQE---NFSSLLT--LLWTHTLRELAEAAASQRSCPLASSRLQVALQNLEMCFHAE
GCGLPPEALHTATFQAVQRDLALQAASSRELIQK

ENSGT00730000110939_1_Linker_3_4 (1115, 1147)

YFSSRIQQQAETTSEELGAVTVKASY
RTSEQK

PF00168 // ENSGT00730000110939_1_Domain_4 (1147, 1251)

LRVELLSASNLLPLDSNGSSDPFVQLTLEPRHMFPELAPRETQKHKKDLH----
---------PLFDETFEFLVPAEPCQKEGACLLLTVLDHDRLGADDLEGEAFLPLRSVPG
LPGNQE-----PGEVPQTRLPLTYPAPNG--------------------------DPILQ
LLESRKGERDTQVFVRLRRQRAKQASQHPLQPGR--------------------------
---------------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MATLLSHPQQRPPFLRQA----------------I-KIRR-----RRV--------RD
LQDPPPQMAPEIQPPSHHFSPEQRALLYEDALYTVLHRLGQPEPNHVTEASELLRYLQEA
FHVEPEEHQQT-L----QRVRELEKPIFC

PF00168 // ENSGT00730000110939_1_Domain_0 (270, 447)

LKATVKQAKGILGKDVSGFSDPYCLLGI-EQ
GVGVPGGSPGS-RQRQKAVVRHTIPEEETHRTQVITQTLNPVWDETFILYV---------
--AVDLDTVESVRQKLGELTDLHG----------LRR--IFKEARKDKGQDDFLGNVVLR
-------------LQDLRCREDQWYPLEPRTETYPDRGQCHLQFQLIHKRR-ATSASRSQ
PSYTVHLHLLQQLVSHEVTQHEAGSTSWDGSLSPQAATVLFLHATQKDLSDFHQSMA-QW
LAYSRLYQSLEFPSSCLLHPITSIEYQWIQGRLKAEQQEELAASFSSLLTYGLSLIRRFR
SVFPLSVSDSPARLQSLLRVL--VQMCKMKAFGELCPNTAPLPQLVTEALQTGTTEWF--
---HLKQQHHQPMVQGIPEAGKALLGLVQDVIGDLHQCQRTWDKIFHNTLKIHLFSMAFR
ELQWLV----AKRVQDHTT-AVGDAVSPEMGESLFQLYISLKELYQLRMSSS-------E
RDGVLALDNFH--RW-FQPAIPSWLQKTYNEALARVQRAVQMDELVPLGELTKHSTSA-V
DLSTCFAQISHTARQLDWPDPEEAFMITVKFVEDTCRLALVYCSLIKARARELSSGQKDQ
GQAANM----LCVVVNDMEQLRLVIGKLPAQLAWEALEQRVGAVLEQGQLQNTLHAQLQS
ALAGLGH-EIRTGVRTLAEQLEVGIAKHIQKLVGVRESVLPEDAI-LPLMKFLEVELCYM
NTNLVQE---NFSSLLT--LLWTHTLTVLVEAA

PF10540 // ENSGT00730000110939_1_Domain_3 (1054, 1114)

ASQRSSSLASNRLKIALQNLEICFHAE
GCGLPPEALHTATFQALQRDLELQAASSRELIR

ENSGT00730000110939_1_Linker_3_4 (1114, 1146)

KYFCSRIQQQAETTSEELGAVTVKASY
RASEQ

PF00168 // ENSGT00730000110939_1_Domain_4 (1146, 1260)

KLRVELLSASSLLPLDSNGSSDPFVQLTLEPRHEFPELAARETQKHKKDLH----
---------PLFDETFEFLVPAEPCRKAGACLLLTVLDYDTLGADDLEGEAFLPLREVPG
LSGSEE-----PGEVPQTRLPLTYPAPNG--------------------------DPILQ
LLEGRKGDREAQVFVRLRRHR--------AKQASQ--HALRPAP----------------
---------------------------------------

---MGQGGSPAGPDAPSWGAPDTPPHTHPTPPGPLGEGVEGPGPPTVSTCLQPGLVPPRI
PAREGGRCRPRGGETLTGTPHLPAPTPRRRRVAPGALCIILWLRYLPPRRQLLGAGKGRA
ATMATLLSHPQRRPPLLRQAIKI-----------------RR-----R-----R--V-RD
LQDPLARPAQEIEPPSHHLSPEERALLYEETLYTVLHRLGQPEPNHVREASELLQYLQEA
FHMGPEEHQQML-----QQVQKLEKPIFC

PF00168 // ENSGT00730000110939_1_Domain_0 (270, 379)

LKATVKQAKGILGKDVSGFSDPYCLLG-IEQ
GVGVPGDSPGS-RHRQKAVVRHTIPEEQTHRTQVITQTLNPVWEETFILEFENISNSSFH
LDMWDLDTVESVRQKLGELTDLHG----------LRR--IFKEARKDKGQDDFLGNVVVR
-------------LQDLHCREDQWYPLEPRTETHPDRGQCHLQFQLIHKRR-ATVASRSQ
PSYSVHLHLLQQLVSHEVTQHQAGSTSWDGSLSPQAATILFLHATQKDLSDFHQSMA-QW
LAYSRLYQSLEFPSSCLLHPITSIEYQWIQGRLKEEQLEELATSFSNLLAYGLSLIRRFR
SVFPLSVSDSPARLQSLLRVL--VQMCKMKAFGELCRDSAPLPHLVTEALKTGTVEWF--
---HLKQQHHQPMVQGMLEAGQALLSLVQDIIVDLRQCQHTWNKIFQNTLKVDLFSMAFL
ELQWLV----AKRVQDHTAVVAGNPVSPEVGESLFQLYVSLKELCQLGPAPA-------E
RDGVQALDGFH--RW-FQPAIPSWLQKTYSVALARVQRAVQMDELVPLGELTKHSTSA-V
DLSTCFAQISHTARQLDWPDPEEAFMITVKFVEDTCRLALVYCSLIKARARELSAGQKDQ
GQAANM----LCVVVNDMEQLRLVIGRLPTQLAWEAVEQRVGAVLEQGQLQNTLHAQLQG
ALAGLGH-EIRTGVRTLAKQLEAGIAKHIQKLVDVKESVLP

PF10540 // ENSGT00730000110939_1_Domain_3 (1002, 1115)

EDAI-LPLMKFLEVKLCYM
NTNLVQE---NFSSLLT--LLWTHTLTVLVDVAASQRSCPLASSRLKIALQNLEICFYAE
GCGLPPAALHTVTFQALRRDLELQAASSRELIQK

ENSGT00730000110939_1_Linker_3_4 (1115, 1147)

YYCSRIQQQAETASEELGAVTVKASY
RASEQK

PF00168 // ENSGT00730000110939_1_Domain_4 (1147, 1251)

LRVELLSASSLLPLDSNGSSDPFVQLTLEPRHEFPELAPRETQRHKKELH----
---------PLFDETFEFLVPAEPCQKDGACLLLTVLDHDTLGADDLEGEAFLPLCSVPG
LTGTEE-----PGEVPQIRLPLTYPALNG--------------------------TK---
------------------------------------------------------------
---------------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MATLLSHLQQRPPLLRQA----------------I-KIRR-----RRV--------RD
LQDPLPQTAPEIQPPSHHFSPEQRALLYEDALYTVLHRLGQPEPNHVTEASELLRYLQEA
FHVEPEEHQQA-L----QRVRELEKPIFC

PF00168 // ENSGT00730000110939_1_Domain_0 (270, 447)

LKATVKQAKGILGKDVSGFSDPYCLLGI-EQ
GVSVPGGSPGS-RPRQKAVVRHTIPEEQTHRTQVITQTLNPVWDETFILEFEDITNASFH
LDMWDLDTVESVRQKLGELTDLHG----------LRR--IFKEARKDKGQDDFLGNVVLR
-------------LQDLHCREDQWYPLEPRTETYPDRGQCHLQFQLIHKRR-ATSASRSQ
PSYTVHLHLLQQLVSHEVTQHQAGSTSWDGSLSPQAATVLFLHATQKDLSDFHQSMA-QW
LAYSRLYQSLEFPSSCLLHPITSIEYQWIQGRLKAEQQEELAASFSSLLAYGLSLIRRFR
SVFPLSVSDSPARLQSLLRVL--VQMCKMKAFGELCPNTAPLPQLVTEALQTGTTEWF--
---HLKQQHHQPMMQGILEAGKALLGLVQDVIGDLHQCQRTWDKIFHNTLKIHLFSMAFR
ELQWLV----AKRVQDHTT-AVGDAVSPEMGESLFQLYISLKELYQLRPSSS-------E
RDGVLALDNFH--RW-FQPAIPSWLQKTYNVALARVQRAVQMDELVPLGELTKHSTSA-V
DLSTCFAQISHTARQLDWPDPEEAFMITVKFVEDTCRLALVYCSLIKARARELSSGQKDQ
GQAANM----LCVVVNDMEQLRLVIGKLPTQLAWEALEQRVGAVLEQGQLQNTLHAQLQS
ALAGLGH-EIRTGVRTLAEQLEVGIAKHIQKLVGVRESVLPEDAI-LPLMKFLEVELCYM
NTNLVQE---NFSSLLT--LLWTHTLTVLVEAA

PF10540 // ENSGT00730000110939_1_Domain_3 (1054, 1114)

ASQRSSSLASNRLKIALQNLEICFHAE
GCGLPPEALHTATFQALQRDLELQAASSRELIR

ENSGT00730000110939_1_Linker_3_5 (1114, 1146)

KYFCSRIQQQADTTSEELGAVTVKACY
RASEQ

PF00168 // ENSGT00730000110939_1_Domain_5 (1146, 1174)

KLRVELLSASSLLPLDSNGSSDPFVQLTLEPRHEFPELAAPSGLLLL--------
----------------HFGRPGQ--------------------ADH-----LRSECCAPP
HSSLPP-----PGTACPPASDPQTPLSAG--------------------------DPILQ
LLEGRKGDREAQVFVRLRRHR--------AKQGIGP--SVSWPICLLAFLFQPL---GWG
P---GSLEPGLQVQSLLGKGGG-PCQR------------

------------------------------------------------------------
------------------------------------------------------------
--MATHLSHPQRRPPLLRQAIKI-----------------RR-----R-----R--A-RD
LQDPPPQTTHEVQVQSHHFSSEERDLLYEEALYTVLHRLGQPEPNHVKEDSELIRYLQEA
FQVQPKEHQQML-----QRVGELEKPIFC

PF00168 // ENSGT00730000110939_1_Domain_0 (270, 447)

LKATVKQAKGILGKDVSGFSDPYCLLGIIEQ
GAGVPEGSPAS-RRRQKAVVKHTIPEEQTHRTQVKSQTLNPVWEETFILEFEDITNASFH
LDMWDLDTVESVRQKLGELTDLHG----------LRR--IFKEARKDKGQDDFLGNVVLR
-------------LQDLHCREDQWYPLEPCTETYPDRGQCHLQFQFIHKRR-ATAASRSQ
PSYTVHFHLLQQLVSYEVTQHQAGSASWDASLSPQGATILFLHATQKDLSDFHQSMA-QW
LAYSRLYQSLEFPSSCLLHPITSIEYQWIQGRLKAEQREELATSFTSLLAYGLSLIRKFR
SVFPLSVSDSPSRLQSLLRVL--VQMCKTKAFGELCPDSAPLSQQVSEALRMGTIEWF--
---HLMQQHHQPM--GILEAGKALLSLVRDVMADLYQCRHTWNKIFHNVLKIDLFSVAFQ
ELQWLV----AKRVQDHTT-AVGSLVSPDMGESLFQLYVSLKELYQLGPVPSD------S
N-GVLALDGFH--CW-FQPAIPSWLQKTYTVALERVQRAVHMDSLVPLGELTKHSTSA-V
DLSTCFAQISHTARQLDWPDPEEAFMITVKFVEDTCRLSLVYCSLIKARARELSVGQKDQ
GQAANM----LCVVVNNMEQLRLIIDKLPTQLAWEALEQRVGAVLEQGQLQNTLHAQLQG
ALAGLGH-EIRTGVRTLAEQLEVGIATHIQKLIGVKESVPPEDAI-LPLMRFLEVELFYM
NTNLVQE---NFSSLLT--LLWTHTLTVLA

PF10540 // ENSGT00730000110939_1_Domain_3 (1051, 1114)

EVASSQRSSPLASSRLKAALQSLEVCFHAE
GCGLPPEALHTATFQALQRDLELQAASSRELIQ

ENSGT00730000110939_1_Linker_3_4 (1114, 1146)

KYFCSRIQQQAETTSEPLGAVTIKASY
RTSEQ

PF00168 // ENSGT00730000110939_1_Domain_4 (1146, 1257)

KLHVELLSASSLLPLDSNGASDPFVQLTLEPRHEFPELAPRETQKHKKELH----
---------PLFDETFEFLVPAEPCQKDWACLLLTVLDHDRLGADDLEGEAFLPLCRVPG
LTGCEE-----PGEAPQTRLPLTYPAPNG--------------------------DPILQ
LLESRKGDREAQAFVKLRRQRAKQASQH---------------------APP--------
---------------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MATLLSHPQRRPPLLRQAIK-----------------IRR-----RRV--------RD
LQDPLPQAAQEIETPSHHFSPEERALLYEEALYTVLHRLGQPEPNHVTEASELLRYLQEA
FHVEPEEHRLML-----QRIRELQKPIFC

PF00168 // ENSGT00730000110939_1_Domain_0 (270, 378)

LKATVKQAKGILGKDVSGFSDPYCLLGI-EQ
GVGLPGGSPGS-RRRQKAVVRHTIPEEQTHRTQVITQTLNPVWDETFILEFEDVTSASFH
LDMWDLDTVESVRQKLGELTDLHG----------LRRWVIFKEARKDKGQDDFLGNPGLG
SATPR----LPCPGSDLRCREDQWYLLEPCTETYPDRGQCHLQFQFIHKRR-ATVASRSQ
PSYTVHLHLLQQLVSHEVTQHQAGSTSWDGSLSPQAATILFLHATQKDLSDFHQAMA-QW
LAYSRLYQSLEFPSSCLLHPITSIEYQWIQGRLKAEQQEELAASFSSLLAYGLSLIKRFR
SVFPLSVSDSPARLQSLLRVL--VQMCKMKAFGELCPDSAPLSQLVTEALRTGTTEWF--
---HLKQQHHQPMVQGMLEAGKALLSLVQDVIGDLHQCQRTWNKIFHNVLKIDLFSMAFL
ELQWLV----AKRVQDHTT-VVGSTVSPEMGESLFPLYVSLKELCQLCPVPS-------E
RDGVLALNGFH--RW-FQPAIPSWLQKTYNVALARVQRAVQMDELVPLGELTKHSTSA-V
DLSTCFAQISHTARQLDWPDPEEAFMITVKFVEDTCRLALVYCSLIKARARELSAGQKDQ
GQAANM----LCVVVNDMEQLRLVIAKLPAQLAWEALEQRVGAVLEQGQLQNTLHAQLQS
ALAGLGH-EIRTGVRTLAEQLEVGIANHIQKLVGIRESVLPEDAI-LPLMKFLVVELRYM
NTNLVQE---NFNSLLT--LLWTHTLAVLVEVAAS

PF10540 // ENSGT00730000110939_1_Domain_3 (1056, 1114)

QHSSALASSRLKIALQNLESCFHAD
GCGLPHEALHTATFQALWRDLELQAASSRELIQKYFCSRIQQQAETTSEELGAVTAKASY
RASEQKLRVELLSASSLLPLDSNGHSCSSLGALLTRQ-----------------EL----
---------RLSPESPCSLVPAEPCRK

PF00168 // ENSGT00730000110939_1_Domain_6 (1228, 1260)

AGACLLFTVLDHDTLGADDLEGEAFLPLCEVPG
LSGSEE-----PGEVPQTRLPLTYPAPNG--------------------------DPILQ
LLESRKGDREAQVFVKLRRQRAKQGLGPSV----------SQPACSS-----HW---GEG
PSSLGPGLQVQSQMRLQLG----------------GNHY

------------------------------------------------------------
------------------------------------------------------------
--MAMLFSRPQRRPPLMRQAIKI-----------------RR-----R-----G--V-RD
LQDTRPPRAQEIEPSSHHLSPEERALLYEEALYTVLYRLGQPEPNHVGESSELLRYLQEA
FRMEPEEHQQML-----KRVQQLEKPVFC

PF00168 // ENSGT00730000110939_1_Domain_0 (270, 379)

LKATVKQAKGILGKDVSGFSDPYCLLG-IEQ
GMTVSGGSPGL-RRRQKAVVRHTIPEEQTHRTQVITQTLNPVWDETFILEFEDISNASFH
LDMWDMDTVESVRQKLGELTDLHG----------LRR--MFKEARKDKGQDDFLGNVVLR
-------------LQDLRCREDHWYPLEPCTDTYPDRGQCHLQFQFIHKRR-ATKASRSQ
PSYTVHLHLLQQLVSHEVTQHQAGSTSWDGSLSSQAATILFLHATQKDLSDFHRSLA-QW
LAYSRLYQSLEFPSSCLLFPITSIEYQWIQGRLKAEQLEELATSFSSLLAYGLSLIRRFR
SVFPLSVPDSPARLQSLLRVL--VQMCKMKAFGELCPNSDPLPSLVSEALRAGTVGWF--
---HLKQQHHQPMVQGLLEMGKALLSLVQDIIGDLHQCQRTWNKIFHNVLKIDLFSMAFL
ELQWL----VAKRVQDHIA-AVGGSVTLEVGESLFQLYVSLKELYQLGPLPS-------E
RDGVLALEGFH--RW-FRPAIPSWLQKTYSVALARVQRAVQMDQLVPLGELTKHSTSA-V
DLSTCFAQISHTAQQLDWPDPEEAFMITVKFVEDTCRLALVYCSLIKARARELSAGQKDQ
GQAANM----LCVVVNDMEQLRLVIGKLPTQLAWEALEQRVGPVLEQEQLQNTLHAQLQG
ALAGLGH-EIRTGVRTLAEQLEAGIAKHIQKLVGIRESVLP

PF10540 // ENSGT00730000110939_1_Domain_3 (1002, 1115)

EDAI-LPLMKFLEVELCYM
NTNLVQE---NFSSLLS--LLWTHTLTVLAEVAASQRSCPRACSRLKFALQNLEVCFYAE
GCGLPPEALHTATFQALQRDLELQAASSRELIHK

ENSGT00730000110939_1_Linker_3_4 (1115, 1147)

YFCSRLQQQAATTSEELGAVTVKASY
RPSEQK

PF00168 // ENSGT00730000110939_1_Domain_4 (1147, 1251)

LRVELLSASNLLPLDSNGSSDPFVQLTLEPRHEFPELAPRETQKHKKDLH----
---------PLFDETFEFLVPAEPCQKDGACLLLSVLDHDTLGTDDLEGEAFLPLCSVPG
LTGMEE-----PGEVPQTRLPLTYPAPNG--------------------------DPILQ
LLESRKGDREAQAFVRLRRQRAKKA--------------------S-QHGPRP-------
------GR-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MATLLSHLQQRPPLLRQA----------------I-KIRR-----RRV--------RD
LQDPLPQTAPEIQPPSHHFSPEQRALLYEDALYTVLHRLGQPEPNHVTEASELLRYLQEA
FHVEPEEHQQA-L----QRVRELEKPVFC

PF00168 // ENSGT00730000110939_1_Domain_0 (270, 447)

LKATVKQAKGILGKDVSGFSDPYCLLGI-EQ
GVGVPGGSPGS-RHRQKAVVRHTIPEEQTHRTQVITQTLNPVWDETFILEFEDITNASFH
LDMWDLDTVESVRQKLGELTDLHG----------LRR--IFKEARKDKGQDDFLGNVVLR
-------------LQDLHCREDQWYPLEPRTETYPDRGQCHLQFQLIHKRR-ATSASRSQ
PSYTVHLHLLQQLVSHEVTQHQAGSTSWDGSLSPQAATILFLHATQKDLSDFHQSMA-QW
LAYSRLYQSLEFPSSCLLHPITSIEYQWIQGRLKAEQQEELAASFSSLLAYGLSLIRRFR
SVFPLSVSDSPARLQSLLRVL--VQMCKMKAFGELCPNTAPLPQLVTEALQTGTTEWF--
---HLKQQHHQPMVQGILEAGKALLGLVQDVIGDLHQCQRTWDKIFHNTLKIHLFSMAFR
ELQWLV----AKRVQDHTT-AVGDAVSPEMGESLFQLYISLKELCQLRPSSS-------E
RDGVLTLDNFH--RW-FQPAIPSWLQKTYNVALARVQRAVQMDELVPLGELTKHSTSA-V
DLSTCFAQISHTARQLDWPNPEEAFMITVKFVEDTCRLALVYCSLIKARARELSSGQKDQ
GQAANM----LCVVVNDMEQLRLVIGKLPTQLAWEALEQRVGAVLEQGQLQNTLHAQLQS
ALAGLGH-EIRTGVRTLAEQLEVGIAKHIQKLVGVRESVLPEDAI-LPLMKFLEVELCYM
NTNLVQE---NFSSLLT--LLWTHTLTVLVEAA

PF10540 // ENSGT00730000110939_1_Domain_3 (1054, 1114)

TSQRSSTLASNRLKIALQNLEICFHAE
GCGLPPEALHTATFQALQRDLELQAASSRELIR

ENSGT00730000110939_1_Linker_3_4 (1114, 1146)

KYFCSRIQQQAETTSEELGAVTVKACY
RASEQ

PF00168 // ENSGT00730000110939_1_Domain_4 (1146, 1260)

KLRVELLSASSLLPLDSNGSSDPFVQLTLEPRHEFPELAARETQKHKKDLH----
---------PLFDETFEFLVPAEPCRKAGACLLLTVLDHDTLGADDLEGEAFLPLCEVPG
LSGSEE-----PGDVPQTRLPLTYPAPNG--------------------------RPEPR
-------------------------------AGEQLPWRWEPPICLLAFLFQPL---GWG
P---GSLEPGLQGGGHY----------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------M-DLSH-----GRP---------G
DGPPGGLLGEQIQPPSHHFSPEQRALLYEDALYTVLHRLGQPEPNHVTDASELLRYLQEA
FHVEPEEHQQA-L----QRVRELEKPIFC

PF00168 // ENSGT00730000110939_1_Domain_0 (270, 379)

LKATVKQAKGILGKDVSGFSDPYCLLGI-EQ
GVGVPGGSPGS-RHRQKAVVRHTIPEEQTHRTQVITQTLNPVWDETFILEFEDITNASFH
LDMWDLDTVESVRQKLGELTDLHG----------LRR--IFKEARKDKGQDDFLGNVVLR
-------------LQDLHCREDQWYPLEPRTETYPDRGQCHLQFQLIHKRR-ATSASRSQ
PSYTVHLHLLQQLVSHEVTQHQAGSTSWDGSLSPQAATVLFLHATQKDLSDFHQSMA-QW
LAYSRLYQSLEFPSSCLLHPITSIEYQWIQGRLKAEQQEELATSFSSLLAYGLSLIRRFR
SVFPLSVSDSPARLQSLLRVL--VQMCKMKAFGELCPNTAPLPQLVTEALQTGTTEWF--
---HLKQQHHQPMMQGILEAGKALLGLVQDVIGDLHQCQRTWDKIFHNTLKIHLFSMAFR
ELQWLV----AKRVQDHTT-AVGDAVSPEMGESLFQLYISLKELCQLRPSSS-------E
RDGVLALDNFH--RW-FQPAIPSWLQKTYNVALARVQRAVQMDELVPLGELTKHSTSA-V
DLSTCFAQISHTARQLDWPNPEEAFMITVKFVEDTCRLALVYCSLIKARARELSSGQKDQ
GQAANM----LCVVVNDMEQLRLVIGKLPTQLAWEALEQRVGAVLEQGQLQNTLHAQLQS
ALAGLGH-EIRTGVRTLAEQLEVGIAKHIQKLVGVRESVLPEDAI-LPLMKFLEVELCYM
NTNLVQE---NFSSLLT--LLWTHTLTVLVEAA

PF10540 // ENSGT00730000110939_1_Domain_3 (1054, 1115)

ASQRSSSLASNRLKIALQNLEICFHAE
GCGLPPEALHTATFQALQRDLELQAASSRELIRK

ENSGT00730000110939_1_Linker_3_4 (1115, 1147)

YFCSRIQQQAETTSEELGAVTVKACY
RASEQK

PF00168 // ENSGT00730000110939_1_Domain_4 (1147, 1251)

LRVELLSASSLLPLDSNGSSDPFVQLTLEPRHEFPELAARETQKHKKDLH----
---------PLFDETFEFLVPAEPCRKAGACLLLTVLDYDTLGADDLEGEAFLPLCEVPG
LSGSEE-----PGEVPQTRLPLTYPAPNG--------------------------DPILQ
LLEGRKGDREAQVFVRLRRHR--------AKQASQHALRPAP------------------
---------------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MATPHSQPLRRLPLLRQAIKMKRQKAK-----------------------------GL
LLETPPQTDQEMEPPSHHFSPEEKALLYEEALYTVLHRIGQPEPKHVAEATELLSYLQEA
FHMTPEVHQQLF-----RKVQDLEKPLFC

PF00168 // ENSGT00730000110939_1_Domain_0 (270, 379)

LKVTVKQAKGILGKDVTGYSDPYCLLGIIEH
GMNMAENDPGSNRRRQKAVVKNTIPEDQTHRTQVISQTLSPEWDETFFLEFEDITTASFH
LDMWDADQVESVRQKLGELTDLHG----------LRR--IFKEARKDKGQDDFLGNVVLR
-------------LQDLHCREDQWYPLEPRTETYPDRGQCHLQFLLIHKRR-ATTASRTH
PSYTVHRHLLQQLVSHEVTQHQAGSTSWDGELSPQASTILFLHATQKDLSEFHQSMA-QW
LAYSRLYQSLEFPGSCLLHPITAIEYQWIQGRLKPEQREELAASFNSLLTYGLSLIRRFR
SIFPLSASGSPARLQSLLRVL--IQMCKMKAFGELCPNGAPLSSLVTEVLRTGTLEWF--
---HLKLQHHQPMVQDMQEMCKAILSLVLDVSGDLHQCQRTWNKIFNNTLKIDLFSMAFS
ELQKLV----AQRVKEHME-MVGSVVNPEMGESLFQLYLSLKELYQLVPPPS-------E
RDGILDLDGFH--KW-FLPAIPAWLLKTYSVALARLQRAVQMDQLVPLGEPIKHSTSA-V
DLSTCFAQISHTARQLDWPDPEVAFMITVKFVEDTCKLALVYCSLIKARAKELSVHQKDQ
GQAANM----LCVVVNNMEQLRLVVLKLPTQLAWKDLEQWAGAILEPEQLQHTLHAQLKG
ALTGLDH-EIRSGVRTLAEQLEAGISRHIQKIVGTSENTVP

PF10540 // ENSGT00730000110939_1_Domain_3 (1002, 1115)

EDAI-LPLMKFLESELCYM
NRNLVQE---NFNSLLL--LLWTHTLSVLTQTAAAQRNSVQISQKLKTALQNLEFCFHAE
GCGLSPEILHTPSLQDLQRNLELQASSTQELIQR

ENSGT00730000110939_1_Linker_3_4 (1115, 1147)

YFSNRIQQQADTTSEEFGAITIKASY
RLSEQK

PF00168 // ENSGT00730000110939_1_Domain_4 (1147, 1251)

LRIEVLSASNLLPLDSNGTSDPFVQLTLEPRHRFAEVAPRETQKFKKELH----
---------PLFDEAFEFLVSLESCQKEGNCLLLTVLDHDRLGTDDLEGEAFLPLNTVLG
LSGDNS-----SGQVPQTRLPLTYPASNG--------------------------DPILQ
LLDLRKGDREAQAFFKLRRQRAKQAETDTLNPAP--------------------------
---------------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MATRLSCPQRRPPLLRQAIKI-----------------RR-----R-----K--V-QD
LPDPLAQMTQEVKPASHHLSPKERDLLYEEALYTVLHRLGQPEPSHVVEASELLRYLQEA
FQMQPEEHQRML-----QQARELKKPIFC

PF00168 // ENSGT00730000110939_1_Domain_0 (270, 447)

LKATVKQAKGILGKDVSGFSDPYCLLGI-EQ
GVGMPGGSPGS-RRRQKAVVRHTIPEEQTHRTQVISQTLNPVWDETFILEFEDIANASFH
LDMWDMDTVESVRQKLGELTDLHG----------LRR--IFKEARKDRGQDDFLGNVVLR
-------------LQDLRCREDQWYPLEPRTETYPDRGQCHLQFQLIHKRR-ATAASRSQ
PSYTMHLHLLQQLVSHEVTQHKVGSTSWDGSLSPQATTILFLHAMQKDLSDFHQSLA-HW
LAYSHLYQSLEFPSSCLLHPITSIEYQWIQGRLKPEQLEELTTSFTSLLAYGLSLIRRFR
SVFPLSVSDSPARLQSLLRVL--VQMCKMKAFGELCQNSTPLPQLVTEALRTGTVEWF--
---HLKQQHHQPMVQGMLEAGKALLSLVQDVLGDLHQCQRTWNKIFHNSLKIDLFSMVFL
ELQWLV----AKRVQDHTS-AVGSPVSPEMAESLFQLYVSLKELCQLGPVPAD------R
D-GVLALDGFH--RW-FQPAIPSWLQKTYSVALERVQRAVQMDKLVPLGELTKHSTSA-V
DLSTCFAQISHTAQQLDWPDPEEAFMITVKFVEDTCRLALVYCSLIKARARALSAGQKDQ
GQAADM----LCVVVNDMEQLRLVIGKLPTQLAWQALEQRVGTVLEQGQLQNTLHTQLQS
ALAGLGH-EIRTGVQTLAEQLEVGIARHIQKLVDVKESVLPE

PF10540 // ENSGT00730000110939_1_Domain_2 (1003, 1051)

DAI-LPLMKFLEVKLCYM
NTNLVQE---NFSSLLT--LLWTHTLTVLVEAAASQRSSTLASGRLKVALQNLEICFHAE
GCGLPPEALHTATFQALQRDLELQAASSRELIRKYFCSRIQQQAETTSEWLGAVTVKASY
RSSEQ

PF00168 // ENSGT00730000110939_1_Domain_4 (1146, 1257)

KLHVELLSASSLLPLDSNGSSDPFVQLTLEPRHEFPELAPRETQKHKKDLH----
---------PLFDETFEFLVAAEPCRKDGACLLLTVLDHDTLGANDLEGEAFLPLCAVPG
LTGCEE-----PGEAPQTRLPLTYPMPNG--------------------------DPILQ
LLEGRKGDREAQAFVRLRRQRAKQASQH---------------------PPRPGQ-----
---------------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MATPLSKPLRRLPLLRQGIKIRRQKAKG-----------------------------L
LLETLPQTDKKMETPSHHFSSEEQALLYEEALYTVLHRLGQPEPKHVTEASELLGYLQEA
FHMEPEVHQQLL-----RKVQDLEKPLFC

PF00168 // ENSGT00730000110939_1_Domain_0 (270, 380)

LKVTVKRAKGILGKDVSGYSDPYCLLGIIEQ
GVSVPDDSPGH-RRRQKAVVKNTIPEDQTHRTQVISQXXXXXXXXXXXXEFEDITTASFH
LDMWDADQVESVRQKLGEL

ENSGT00730000110939_1_Linker_0_1 (380, 643)

TDLHG----------LRR--IFKEARKDKGQDDFLGNVVLR
-------------LQDLRCREDQWYPLEPRTETYPDRGQCHLQFLLIHKRR-ATTTSRTH
PSYTVHRHLLQQLVSHEVTQHEAGSTSWDGELSPA-STILFLHATQ-DLSEFHQSAXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXX

PF06292 // ENSGT00730000110939_1_Domain_1 (643, 722)

XXXXXXXXXTGTLEWF--
---HLKQQHHQPMVQDMLEMCKSVLSLVLDVSGDLHQCQRTWNKIFYNTLKINFFSMAFL
ELQKLV----AQRVKEHMA-MVGSVVSPEMGESLFQLYLSLKELYELVPPPSEXXXXXXX
XXXXXXXXXXX----------XXXXXXXXXXXXXXXXXXXXXXXLVPLGEMIKHSTSA-V
DLSTCFAQIGHTARQLDWPDPEVAFMITVKFVEDTCKLALVYCSLIKARAKELSVNQKDX
XXXXXX----LCVVVNNMEQLRLVVLKLPIQLAWKDLEQWAGAILEPEQLQHTLHAQLQG
ALAGLDH-EIRSGVRTLAEQLEAGISRHIQKIVGSSKTTVPEDAI-LPLMKFLESELHYM
NSNLVQE---NFNSLLS--LLWTHTLSVLTQTAAAQQSSPLTSQKLKTALQNLELCFYGE
GCGLSPEVLHTPSLQDLQRKLELQASSSQELIQRYFSNRIQQQADTTSEELGAITIKVFY
RLSEQK

PF00168 // ENSGT00730000110939_1_Domain_4 (1147, 1217)

LRIEVLSASNLLPLDSNGTSDPFVQLTLEPRHEFAEVAPRETQKFKKELH----
---------PLFDEAFE-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MATHLSHPQRRPPLLRQAVKI-----------------RR-----R-----R--V-RD
LQDPPPQATPEVQVQSHHFSPEERDLLYEEALYTILHRLGQPEPNHVKEASELLCYLQEA
FQVQPEEHQQML-----QRVRELEKPIFC

PF00168 // ENSGT00730000110939_1_Domain_0 (270, 447)

LKATVKQAKGILGKDVSGFSDPYCLLGI-EQ
KVGVPEGSPVS-RRRQKAVVRHTIPEEETHRTQVKTQTLNPVWDETFILEFEDITNASFH
LDMWDLDTVESVRHKLGELTDLHG----------LRR--IFKEARKDKGQDDFLGNVMLR
-------------LQDLRCREDQWFPLEPCTETYPDRGQCHLQFQFIHKRR-ATVASRSQ
PSYTVHFHLLQQLVSHEVTQHQAGGTSWDASLSPQAVTILFLHATQKDLSDFHQSMA-QW
LAYSRLYQSLEFPSSCLLHPITSIEYQWIQGRLKAEQREELATSFTSLLAYGLSLIRKFR
SVFPLSVSDSPSRLQSLLRVL--VQMCKMKAFGELCPDSAPLPQLVSEALRMGTVEWF--
---HLMQQHHQPMVQGILEAGKALLSLVQDVMGDLYQCRRTWNKIFHNVLKIDLFTMAFL
ELQWLV----AKRVQDHTA-AVGDLVSPDVGESLFQLYVSLREFCQLGP--SD------S
H-EVLALDGFH--RW-FQSAIPSWLQRTYSVALERVQRAVQMDSLVPLGELTKHSTSA-V
DLSTCFAQISHTARQLDWPDPEEAFMITVKFVEDTCRLALVYCSLIKARARELSAVQKDQ
SQAADM----LCVVVNNVERLRLIIDKLPTQLAWEALEQRVGAVLEQGQLQNTLHTQLQG
ALAGLGH-EIRTGVRTLAEQLEVGIATHIQKLIDAKGSILPE

PF10540 // ENSGT00730000110939_1_Domain_3 (1003, 1114)

DAI-LPLMKFLEVKLCYM
NTNLVQE---NFSSLLT--LLWTHTLTVLVEAAASHRNSSLASSRLKVALQNLEICFHAE
GCGLPPEALHTDTFLALQSDLELQAASSRELIQ

ENSGT00730000110939_1_Linker_3_4 (1114, 1146)

KYFRSRIQQQAETTSERLGAVTVKASY
RASEQ

PF00168 // ENSGT00730000110939_1_Domain_4 (1146, 1257)

KLHVELLSASSLLPLDSNGSSDPFVQLTLEPRHEFPELAPRETQKHKKELH----
---------PLFDETFEFLVPAEPCQKDGACLLLTVLDHDRLGADDLEGEAFLPLCRVPG
LTGCVE-----PGEAPQMRLPLTYPAPNG--------------------------DPILR
LLESRKGDREAQAFVKLRRQRAKQASQH---------------------APATEP-----
---------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------DLELQAASQPGAHPEVLRGRLRQQAETTSEDLGAVTVKASY
RVSEQK

PF00168 // ENSGT00730000110939_1_Domain_4 (1147, 1251)

LRVELLSASSLLPLDSNGSSDPFVQLTLEPRHEFPGLAPRETQKHRKDLH----
---------PLFDETFEFLVPAEPCRRDGACLLLTVLDHDTLGADDLEGEAFLPLCSVPG
LSSSEE-----AGEVPQTRLPLTYPEPTG--------------------------DPILQ
LLESRRGDREAQVFVRLRRLRAKQ------------------------------------
---------------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MATRLSHSQRRPPLLRQAIKI-----------------RR-----R-----K--V-QD
LPDPLAQMTQKVKPASHHFSPKERDLLYEEALYTVLHRLGQPEPNHVVEASELLRYLQEA
FQMQPEEHQRML-----QQARELEKPIFC

PF00168 // ENSGT00730000110939_1_Domain_0 (270, 447)

LKATVKQAKGILGKDVSGFSDPYCLLGI-EQ
GVGVPGGSPGS-RRRQKAVVRHTIPEEQTHRTQVISQTLNPVWDETFILEFEDVTNASFH
LDMWDMDTVESVRQKLGELTDLHG----------LRR--IFKEARKDKGQDDFLGNVVLR
-------------LQDLRCREDQWYPLEPRTETYPDRGRCHLQFQLIHKRR-ATAASRSQ
PSYTVHLRLLQQLVSHEVTQHKVGSTSWDGLLSPQATTILFLHAMQKDLSDFHQSLA-HW
LAYSHLYQSLEFPSSCLLHPITSIEYQWIQGRLKPEQLEELTTSFTSLLAYGLSLIRRFR
SIFPLSVSDSPARLQSLLRVL--VQMCKMKAFGELCQDSAPLPQLVAEALRTGTVEWF--
---HLKQQHHQPMVQGMVEAGKALLSLVQDVLGDLHQCQRIWNKIFHNALKIDLFSMAFL
ELQWLV----AKRVQDHTS-AVGSPVSAEMGESLFQLYISLKELCQLGPGSAD------R
D-GVLALDHFH--RW-FQPAIPSWLQKTYSVALERVQRAVQMDKLVPLGELTKHSTSA-V
DLSTCFAQISRTARQLDWPDPEEAFMITVKFVEDTCRLALVYCSLIKARARALSAGQKDQ
GQAADM----LCVVVNDMEQLRLVIGKLPTQLAWEDLEQRVGTVLEQGQLQNTLHTQLQS
ALAGLGH-EIRTGVQTLAEQLEVGIARHIQKLVDVKESVLPE

PF10540 // ENSGT00730000110939_1_Domain_2 (1003, 1050)

DAI-LPLMKFLEVKLCYM
NTNLVQE---NFSSLLT--LLWTHTLTVLVETAASQRSSTLASGRLKVALQNLEICFHAE
GCGLPPEALHTATFQALQRNLELQAASSRELIRKYFCSRIRQQAETTSEQLGAVTVKASY
RPSEQ

PF00168 // ENSGT00730000110939_1_Domain_4 (1146, 1257)

KLHVELLSASSLLPLDSNGSSDPFVQLTLEPRHEFPELAPRETQKHKKDLH----
---------PLFDETFEFLVPAKLCQKDGACLLLTVLDHDTLGANDLEGEAFLPLCAVPG
LTGCKE-----PGEAPQTRLPLTYPMPNG--------------------------DPILQ
LLESRKGDREAQAFVRLRKQRARQASQH---------------------APR--------
---------------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MATLLSHLQQRPPLLRQA----------------I-KIRR-----RRV--------RD
LQDPLPQTAPEIQPPSHHFSPEQVRVRVLGCR-----EVGRAAVH------PPV------
--TWGRGHPGL-R----PSLLSLQKPIFC

PF00168 // ENSGT00730000110939_1_Domain_0 (270, 447)

LKATVKQAKGILGKDVSGFSDPYCLLGI-EQ
GVSVPGGSPGS-RHRQKAVVRHTIPEEQTHRTQVITQTLNPVWDETFILEFEDITNASFH
LDMWDLDTVESVRQKLGELTDLHG----------LRR--IFKEARKDKGQDDFLGNVVLR
-------------LQDLHCREDQWYPLEPRTETYPDRGQCHLQFQLIHKRR-ATSASRSQ
PSYTVHLHLLQQLVSHEVTQHQAGSTSWDGSLSPQAATVLFLHATQKDLSDFHQSMA-QW
LAYSRLYQSLEFPSSCLLHPITSIEYQWIQGRLKAEQQEELAASFSSLLAYGLSLIRRFR
SVFPLSVSDSPARLQSLLRVL--VQMCKMKAFGELCPNTAPLPPLVTEALQVWGWCLP--
---LAALPSPPLSLQGILEAGKALLGLVQDVIGDLHQCQRTWDKIFHNTLKIHLFSMAFR
ELQWLV----AKRVQDHTT-AVGDAVSPEMGESLFQLYISLKELCQLRPSSS-------E
RDGVLALDNFH--RW-FQPAIPSWLQKTYNVALARVQRAVQMDELVPLGELTKHSTSA-V
DLSTCFAQISHTARQLDWPDPEEAFMITVKFVEDTCRLALVYCSLIKARARELSSGQKDQ
GQAANM----LCVVVNDMEQLRLVIGKLPTQLAWEALEQRVGAVLEQGQLQNTLHAQLQS
ALAGLGH-EIRTGVRTLAEQLEVGIAKHIQKLVGVRESVLPE

PF10540 // ENSGT00730000110939_1_Domain_3 (1003, 1114)

DAI-LPLMKFLEVELCYM
NTNLVQE---NFSSLLT--LLWTHTLTVLVEAAASQRSSSLASNRLKIALQNLEICFHAE
GCGLPPEALHTATFQALQRDLELQAASSRELIR

ENSGT00730000110939_1_Linker_3_4 (1114, 1146)

KYFCSRIQQQAETTSEELGAVTVKACY
RASEQ

PF00168 // ENSGT00730000110939_1_Domain_4 (1146, 1260)

KLRVELLSASSLLPLDSNGSSDPFVQLTLEPRHEFPELAARETQKHKKDLH----
---------PLFDETFEFLVPAEPCRKAGACLLLTVLDYDTLGADDLEGEAFLPLCEVPG
LSGSEE-----PGEVPQTRLPLTYPAPNG--------------------------DPILQ
LLEGRKGDREAQFFVRLRRHR--------AKQGIGP--SVSWPICLLAFLFQPL---GWG
P---GSLEPGLQVQSLLGKGGG-PCQR------------

------------------------------------------------------------
------------------------------------------------------------
--MATPFSHPQRRPPLLRQAIKI-----------------RR-----RRA---G--RCAQ
SPAPQGSGAPQVEPPSHHFSPEERTLLYEEALYTVLHRLGQPEPNHVAESSELLRYLQEA
FQLEPEEHQRML-----QQALELEKPMFF

PF00168 // ENSGT00730000110939_1_Domain_0 (270, 380)

LKATVKQAKGILGKDVSGFSDPYCLLGI-EQ
GVGVPGGSPGA-RQRQKAVVRDTIPEEQTHRTQVVTQTLNPVWDETFILEFKDIANASFH
LDMWDLDTVESVRQKLGEL

ENSGT00730000110939_1_Linker_0_1 (380, 643)

TDLHG----------LRR--ILKEVRKDKGQDDFLGNLVLR
-------------LQDLRCREDQWYPLGPCTETYPDRGQCHLQFQFIHKRR-ATRASRSQ
PSYTVHLHLLQQLVSHEVTRHQAGSTSWDGTLSPQAATILFLHATQKDLSDFHQSMA-QW
LAYSRLYQSLEFPSSCLLHPITSIEYQWIQGRLKEEQLEELATSFGSLLAYGLSLIRRFR
SVFPLSVADSPVRLQSLLRVL--VQMCKMKAFGELCPDSAPL

PF06292 // ENSGT00730000110939_1_Domain_1 (643, 722)

PHLVTEALRTGTVEWF--
---HLKQQHHQPMVQGLLEAGKALLRLVQDVTGDLHQCQRTWNKIFRNALKIDLFPMAFL
ELQWLV----AKRVQDYTA-AVGGQVSPEMGDTLFQLYISLKEFCQLGPDLS-------E
REGVLALDGEGGRGWTWQGPEPSFLL------------PAVPHQLVPLGELTKHSTSA-V
DLSTCFAQISHTARQLDWPNPEEAFMITVKFVEDTCRLALVYCSLIKARARELSAGQKDQ
GQAANM----LCVVVNNMEQLRLVIGKLPTQLAWEALEQRVGAVLEQGQLQHTLHAQLQG
ALAGLGH-EIRTGVRTLAEQLEVGIAKHIQKLLSIRESILPEDAIYLPLMKFLEVELCYM
NTNLVQE---NFSSLLT--LLWTHTLTVLAEVAPSQRSSPLAANRLKIALQNLEICFHAE
GCGLPPEALHTATFQALQRDLALQAASSRELIQKYFCSRLKQQAETTSEELGVVTVKASY
QASEQK

PF00168 // ENSGT00730000110939_1_Domain_4 (1147, 1252)

LRVELLSASSLLPLDSNGESTPFVQLSLAGSS-HPGLSPCIWRNGSEQGR----
---------QLSLCPLPSLVPAEPCQKEGACLLLTVLDHDTLGADDLEGEAFLPLCSVPG
LPGSEE-----PEEVPQTRLPLTYPAPSG--------------------------DPILQ
LLESR-GDREAQAFVRMRRQRAKQAAQHP-------------P--------RPGQ-----
---------------------------------------

------------------------------------------------------------
----------------------------------------------------MLPRPGNH
SKKPGKRAPRVQRPPLLRQAIKI-----------------RR-----R-----K--V-QD
LQDPLAQMTQEVNPASYHFSPKERDLLYEEVLYTVLYRLGQPEPNHVVEASELLQYLQEA
FQVQPEEHKRML-----QQAKELEKPIFC

PF00168 // ENSGT00730000110939_1_Domain_0 (270, 447)

LKATIKQAKGILGKDVSGLSDPYCLLGI-EQ
GVSMPGGSPGS-RRRQKAVVRYTIPEEQTHRTQVISQTLNPVWDETFILEFEDITNASFH
LDMWDMDTVESVRQKLGELTDLHG----------LRR--IFKEARKDKGQDDFLGNVVLR
-------------LQDLHCREDQWYPLEPRTETYPDRGWCHLQFQLIHKRR-ATAASRSQ
PSYTVHLHLLQQLVSHEVTQHKVGSTSWDGSLSPQATTILFLHAMQKDLSDFHQSLA-QW
LAYSHLYQKLEFPSSCLLHPITSIEYQWIQGRLKTEQLEELTLSFTSLLAYGLSLIRKFR
SVFPLSVSDSPARLQSLLRVL--VQMCKMKAFGELCQDTAPLPQLVTEALQTGTVEWF--
---HLKQQHHQPMVQGMLEAGKALLSLVQDVLGDLHQCQRTWNKIFYNALKIDLFSTAFL
KLQWLV----AKRVQDHTS-AVGSPVSPEMGENLFQLYISLKELYQLGSASLD------R
D-GVLALDGFH--HW-FQPAIPSWLQKTYSVALERVQRAVQMDKLVPLGELTKHSTSA-V
DLSTCFAQISHTARQLDWPDPEVAFMITVKFVEDTCRLALVYCSLIKARARTLSAGQKDQ
GQAADM----LCVVVNDMEQLRLVIGKLPSQLAWEALERRVGTVLDQGQLQNTLHTQLQS
ALAGLGH-EIRTGVQTLAEQLEVGIAKHIQKLVDVKESVLPEDAI-LPLMKFLEVKLCYM
NTNLVQE---NFSSLLT--LLWTHTLTVLVEV

PF10540 // ENSGT00730000110939_1_Domain_3 (1053, 1114)

TASQRSSTLASGRLKVALENLEICFHAE
GCGLPFEALHTATFQALQRDLELQAASSQELIR

ENSGT00730000110939_1_Linker_3_4 (1114, 1146)

KYFCSRIQQQAETTSEQLGAVTVKASY
HSSEQ

PF00168 // ENSGT00730000110939_1_Domain_4 (1146, 1257)

KLYVELLSASNLLPMDSNGSSDPFVQLTLEPRHEFPELAPRETQKHKKDLH----
---------PLFDETFEFLVPAEPCQKDGACLLLTVLDHDTLGANDLEGEAFLPLCTVPG
LSGCEE-----PSEAPQTRLPLTYPVPDG--------------------------DPILQ
LLESRKGDREAQAFVRLRRQRAKQASQH---------------------APRPGQ-----
---------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------IQPPSHHFSPEQRALLYEDALYTVLHRLGQPEPNHVTEASELLRYLQEA
FHVEPEEHQQA-L----QRVRELEKPVFC

PF00168 // ENSGT00730000110939_1_Domain_0 (270, 447)

LKATVKQAKGILGKDVSGFSDPYCLLGI-EQ
RVGVPGGSPGS-RHRQKAVVRHTIPEEQTHRTQVITQTLNPVWDETFILEFEDITNASFH
LDMWDLDTVESVRQKLGELTDLHG----------LRR--IFKEARKDKGQDDFLGNVVLR
-------------LQDLHCREDQWYPLEPRTETYPDRGQCHLQFQLIHKRR-ATSASRSQ
PSYTVHLHLLQQLVSHEVTQHQAGSTSWDGSLSPQAATVLFLHATQKDLSDFHQSMA-QW
LAYSRLYQSLEFPSSCLLHPITSIEYQWIQGRLKAEQQEELATSFSSLLAYGLSLIRRFR
SVFPLSVSDSPARLQSLLRVL--VQMCKMKAFGELCPNTAPLPQLVTEALQTGTTEWF--
---HLKQQHHQPMVQGILEAGKALLGLVQDVIGDLHQCQCTWDKIFHNTLKIHLFSMAFR
ELQWLV----AKRVQDHTT-AVGDAVSPEMGESLFQLYISLKELCQLRPSSS-------E
RDGVLALDNFH--RW-FQPAIPSWLQKTYNVALARVQRAVQMDELVPLGELTKHSTSA-V
DLSTCFAQISHTARQLDWPDPEEAFMITVKFVEDTCRLALVYCSLIKARARELSSGQKDQ
GQAANM----LCVVVNDMEQLRLVIGKLPTQLAWEALEQRVGAVLEQGQLQNTLHAQLQS
ALAGLGH-EIRTGVRTLAEQLEVGIAKHIQKLVGVRESVLPEDAI-LPLMKFLEVELCYM
NTNLVQE---NFSSLLT--LLWTHTLTVLVQAA

PF10540 // ENSGT00730000110939_1_Domain_3 (1054, 1114)

ASQRSSTLASNRLKIALQNLEICFHAE
GCGLPPEALHTATFQALQRDLELQAASSRELIR

ENSGT00730000110939_1_Linker_3_4 (1114, 1146)

KYFCSRIQQQAETTSEELGAVTVKACY
RASEQ

PF00168 // ENSGT00730000110939_1_Domain_4 (1146, 1241)

KLRVELLSASSLLPLDSNGSSDPFVQLTLEPRHEFPELAARETQKHKKDLH----
---------PLFDETFEFWAGEGLS----------LVSFQVVGG--------IGQCCAPP
HSSLPP-----PGTASPPASDPQTPLSAG--------------------------DPILQ
LLEGRKGDREAQVFVRLRRHR--------AKQGIGP--SASWPICLLAHLPPGL---PVP
ATGVGSRFTGTR--ATGEGGGHY----------------

------------------------------------------------------------
------------------------------------------------------------
--MATLLSHLQQRPPLLRQA----------------I-KIRR-----RRV--------RD
LQDPLPQTAPEIQPPSHHFSPEQRALLYEDALYTVLHRLGQPEPSHVTEASELLRYLQEA
FHVEPEEHQQA-L----QRVRELEKPIFC

PF00168 // ENSGT00730000110939_1_Domain_0 (270, 447)

LKATVKQAKGILGKDVSGFSDPYCLLGI-EQ
GVSVPGGSPGS-RHRQKAVVRHTIPEEQTHRTQVITQTLNPVWDETFILEFEDITNASFH
LDMWDLDTVESVRQKLGELTDLHG----------LRR--IFKEARKDKGQDDFLGNVVLR
-------------LQDLHCREDQWYPLEPRTETYPDRGQCHLQFQLIHKRR-ATSASRSQ
PSYTVHLHLLQQLVSHEVTQHQAGSTSWDGSLSPQAATVLFLHATQKDLSDFHQSMA-QW
LAYSRLYQSLEFPSSCLLHPITSIEYQWIQGRLKAEQQEELAASFSSLLAYGLSLIRRFR
SVFPLSVSDSPARLQSLLRVL--VQMCKMKAFGELCPNTAPLPQLVTEALQTGTTEWF--
---HLKQQHHQPMMQGILEAGKALLGLVQDVIGDLHQCQRTWDKIFHNTLKIHLFSMAFR
ELQWLV----AKRVQDHTT-AVGDAVSPEMGESLFQLYISLKELCQLRPSSS-------E
RDGVLALDNFH--RW-FQPAIPSWLQKTYNVALARVQRAVQMDELVPLGELTKHSTSA-V
DLSTCFAQISHTARQLDWPDPEEAFMITVKFVEDTCRLALVYCSLIKARARELSSGQKDQ
GQAANM----LCVVVNDMEQLRLVIGKLPTQLAWEALEQRVGAVLEQGQLQNTLHAQLQS
ALAGLGH-EIRTGVRTLAEQLEVGIAKHIQKLVGVRESVLPEDAI-LPLMKFLEVELCYM
NTNLVQE---NFSSLLT--LLWTHTLTVLVEAA

PF10540 // ENSGT00730000110939_1_Domain_3 (1054, 1114)

ASQRSSSLASNRLKIALQNLEICFHAE
GCGLPPEALHTATFQALQRDLELQAASSRELIR

ENSGT00730000110939_1_Linker_3_4 (1114, 1146)

KYFCSRIQQQAETTSEELGAVTVKACY
RASEQ

PF00168 // ENSGT00730000110939_1_Domain_4 (1146, 1260)

KLRVELLSASSLLPLDSNGSSDPFVQLTLEPRHEFPELAARETQKHKKDLH----
---------PLFDETFEFLVPAEPCRKAGACLLLTVLDYDTLGADDLEGEAFLPLCEVPG
LSGSEE-----PGEVPQTRLPLTYPAPNG--------------------------DPILQ
LLEGRKGDREAQFFVRLRRHR--------AKQGIG--PSVSWPICLLAFLFQPL---GWG
P---GSLEPGLQVQSLLGKGGG-PCQR------------

------------------------------------------------------------
------------------------------------------------------------
--MATSLSHPQRRPPLLRQAIKI-----------------RR-----R-----R--V-RD
LQDALPPTTQEIEPPSHHFSPEERDLLYEEALYTVLHRLGQPEPNHVTKASELLGYLQEA
FQLQPGEHQQML-----QRVRELERPVFC

PF00168 // ENSGT00730000110939_1_Domain_0 (270, 447)

LKATVKQAKGILGKDVSGFSDPYCLLGI-EQ
GVGVPGGSPGS-RRRQKAVVRHTIPEEQTHRTQVVNQTLNPVWDETFILEFEDITNASFH
LDMWDLDTVESVRQKLGELTDLHG----------LRR--IFKEARKDKGQDDFLGNVVLR
-------------LQDLHCREDQWYPLEPCTETYPDRGQCHLQFQLIHKRR-ATAASRSQ
PSYTVHRHLLQQLVSHEVTQHQAGSTSWDGSLSPQATTILFLHATQKDLSDFHQSMA-QW
LAYSRLYQSLEFPSSCLLHPITSMEYQWIQGRLKAEQLEELATSFTSLLAYGLSLIRRFR
SVFPLSVSDSPSRLQSLLRVL--VQMCKMKAFGELCSDSAPLPQLVMEALRTGTVEWF--
---HLKQQHHQPMVQGMLEAGKALLNLVQDVMGDLHQCQRTWNKIFQNVLKIDLFSMAFL
ELQWLV----AKRAQDHTS-AVGSPVSPEMGESLFQLYISLKELCQLGPVSLD------R
D-RVLALDSFH--RW-FQPAIPSWLQKTYSVALERVQRAVQMDKLVPLGELTKHSTSA-V
DLSTCFAQISHTARQLDWPDPEEAFMITVKFVEDTCRLALVYCSLIKARARELSAGQKDQ
GQAANM----LCVVVNDMEQLRLVIGKLPAQLAWEALEQRVGALLEHGQLQNTLHAQLQG
ALAGLGH-EICTGVRTLAEQLEVGIAKHIERLVGVKESVLPEDAI-LPLMKFLEVELCYM
NTNLVQE---NFNSLLT--LLWTHTLTVLAEA

PF10540 // ENSGT00730000110939_1_Domain_3 (1053, 1114)

SASQRSSSLASSRLKVALQNLEICFHAE
GCGLPPEALHTATFQALQRDLELQAASSRELIQ

ENSGT00730000110939_1_Linker_3_4 (1114, 1146)

KYFCSRIQQQVETTSEELGAVTVKASY
RASEQ

PF00168 // ENSGT00730000110939_1_Domain_4 (1146, 1263)

KLHVELLSASGLRPLDSNGSSDPFVQLTLEPRHEFPELAPRETQKHKKDLH----
---------PLFDETFEFLVPAEPCQKDGSCLLLTVLDHDTLGADDLEGEAFLPLRGVPG
LTSS-E-----PSEAPQMRLPLTYPAPNG--------------------------DPILQ
LLESRKGDREAQAFVRLRRQRAKQASQH---------------------ALRPGQ-----
---------------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MATLPSRPQQRPPLLRQA----------------I-KIRR-----RRV--------KD
LQNPLPQTAPEIQPPSHHFSPEQRALLYEDALYTVLHRLGRPEPNHVTEASELLRYLQEL
PHPVPPATHLATLGKEGPPLLSIQKPTFC

PF00168 // ENSGT00730000110939_1_Domain_0 (270, 447)

LKATVKQAKGILGKDVSGFSDPYCLLGI-EQ
GVGAPGGSPGS-RRQQKAVVKHTIPEEQTHRTQVVTQTLNPVWDETFILEFEDITNSSFH
LDMWDLDTVESVRQKLGELTDLHG----------LRR--IFKEARKDKGQDDFLGNVVLR
-------------LQDLRCREDQWYPLEPRTETYPDRGQCHLQFQLIHKRR-ATSASRSQ
PSYTVHLHLLQQLVSHEVTQHQAGSTSWDGSLSPQAATVLFLHATQKDLSDFHQSMA-QW
LAYSRLYQSLEFPSSCLLHPITSIEYQWIQGRLKAEQEEELAASFSSLLAYGLSLIQRFR
SVFPLSVSDSPARLQSLLRVL--VQMCKMKAFGELCPNTAALPQLVTEALQTGTTEWF--
---HLKQQHHQPMMQGMLEAGKALLGLVQDIIGDLHQCQRTWDKIFHNTLKIHLFPMAFR
ELQWLV----AKRVQDYTE-AVGDAVSPEMGESLFQLYISLKELCQLRPSSS-------E
RDGVMALESFH--RW-FQPAIPSWLQKTYSVALARVQRAVQMDELVPLGELTKHSTSA-V
DLSTCFAQISHTARQLDWPDPEEAFMITVKFVEDTCRLALVYCSLIKARARELSSGQKDQ
AQAANM----LCVVVNDMEQLRLVIGKLPAQLAWEALEQRVGAVLEQGQLQNTLHAQLQS
ALAGLGH-EIRTGVHTLAEQLEVGIAKHIQKLVGVRESVLPE

PF10540 // ENSGT00730000110939_1_Domain_2 (1003, 1052)

DAI-LPLMKFLEVELCYM
NTNLVQE---NFSSLLT--LLWTHTLTVLEEVAASQRSSSLASNRLKIALQNLEICFHAE
GCGLPPEALYTATFQALQRDLELQAASSRELIRRYFCGRIQQQAETISEELGAVTVKASY
RTSEQ

PF00168 // ENSGT00730000110939_1_Domain_4 (1146, 1260)

KLRVELLSASSLLPLDSNGSSDPFVQLTLEPRHEFPELASRETQKHKKDLH----
---------PLFDETFEFLVPAEPCRKPGACLLLTVLDYDTLGADDLEGEAFLPLCEVHG
LSGSEE-----PGEVPQTRLPLTYPAPNG--------------------------RPEPR
E--GWYRDRE---PVKLRQGDARVGEQPFWRWELLLWWAGDGAIRLLAFLFQPL---GWG
PGSLGAG-----LQAQREGGDHY----------------

------------------------------------------------------------
------------------------------------------------------------
--MATRLSRPQQRPPLLRQAIKI-----------------RR-----R-----K--V-QD
LQDPLAQMTQEVNPASYHFSPKERDLLYEEVLYTVLYRLGQPEPNHVVEASELLQYLQEA
FQVQPEEHKR-------------------------------------LSDPYCLLGI-EQ
GVSMPGGSPGS-RRRQ

PF00168 // ENSGT00730000110939_1_Domain_0 (317, 447)

KAVVRYTIPEEQTHRTQVISQTLNPVWDETFILYVAP-------
-PHMDMDTVESVRQKLGELTDLHG----------LRR--IFKEARKDKGQDDFLGNVVLR
-------------LQDLHCREDQWYPLEPRTETYPDRGWCHLQFQLIHKRR-ATAASRSQ
PSYTVHLHLLQQLVSHEVTQHKVGSTSWDGSLSPQATTILFLHAMQKDLSDFHQSLA-QW
LAYSHLYQKLEFPSSCLLHPITSIEYQWIQGRLKTEQLEELTLSFTSLLAYGLSLIRKFR
SVFPLSVSDSPARLQSLLRVL--VQMCKMKAFGELCQDTAPLPQLVTEALQVW-------
-------------------------------------HLRTWNKIFYNALKIDLFSTAFL
KLQWLV----AKRVQDHTS-AVGSPVSPEMGENLFQLYISLKELYQLGSASLD------R
D-GVLALDGFH--HW-FQPAIPSWLQKTYSVALERVQRAVQMDKLVPLGELTKHSTSA-V
DLSTCFAQISHTARQLDWPDPEVAFMITVKFVEDTCRLALVYCSLIKARARTLSAGQKDQ
GQAADM----LCVVVNDMEQLRLVIGKLPSQLAWEALERRVGTVLDQGQLQNTLHTQLQS
ALAGLGH-EIRTGVQTLAEQLEVGIAKHIQKLVDVKESVLPEDAI-LPLMKFLEVKLCYM
NTNLVQE---NFSSLLT--LLWTHTLTVLVEV

PF10540 // ENSGT00730000110939_1_Domain_3 (1053, 1114)

TASQRSSTLASGRLKVALENLEICFHAE
GCGLPFEALHTATFQALQRDLELQAASSQELIR

ENSGT00730000110939_1_Linker_3_4 (1114, 1146)

KYFCSRIQQQAETTSEQLGAVTVKASY
HSSEQ

PF00168 // ENSGT00730000110939_1_Domain_4 (1146, 1257)

KLYVELLSASNLLPMDSNGSSDPFVQLTLEPRHEFPELAPRETQKHKKDLH----
---------PLFDETFEFLVPAEPCQKDGACLLLTVLDHDTLGANDLEGEAFLPLCTVPG
LSGCEE-----PSEAPQTRLPLTYPVPDG--------------------------DPILQ
LLESRKGDREAQAFVRLRRQRAKQASQH---------------------APRPGQ-----
---------------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MATHLSHPHRRPALLRQAVKI-----------------RR-----R-----R--V-RD
LQDPPPQTTQEVQVQSHHFSSEERDLLYEEALYTVLHRLGQPEPNHVKEASELLRYLQEA
FQVQPEEHQQML-----QRVGELEKPIFC

PF00168 // ENSGT00730000110939_1_Domain_0 (270, 447)

LKATVKQAKGILGKDVSGFSDPYCLLGIIEQ
GAGIAEGSPVS-RRRQKAVVKHTIPEEQTHRTQVKNQTLNPVWDETFVLEFEDITNASFH
LDMWDLDTVESVRQKLGELTDLHG----------LRR--IFKEARKDKGQDDFLGNVVLR
-------------LQDLRCRQDQWYPLEPCTETYPDRGQCHLQFQFIHKRR-ATVASRSQ
PSYTVHFHLLQQLVSHEVTQHQAGSASWDASLSPQGATILFLHATQKDLSDFHQSMA-QW
LAYSRLYQSLEFPSSCLLHPITSMEYQWIQGRLRAEQREELAASFTSLLTYGLSLIRKFR
SVFPLSVSDSPSRLQSLLRVL--VQMCKTKAFGELCPDSAPLSQLVSEALRTGTVEWF--
---HLMQQHHQPMVQGILEAGKALLSLVQDVMGDLYQCRHTWNKIFHNVLKIDLFSVAFL
ELQWLV----AKRVQDHTA-EAGKLVSPDMGEILFQLYVSLKEISQLGPGPSS------S
N-GVLALDGFH--RW-FQPAIPSWLQKTYSVALERVQRAVRMDSLVPLGELTKHSTSA-V
DLSTCFAQISHTARQLDWPDPEEAFMITVKFVEDTCRLALVYCSLIKARARELSTGQKDQ
GQAANM----LCVVVNNMEQLRLIIDKLPTQLAWEALEQRVGAVLEQGQLHNTLHAQLQG
TLAGLGH-EIRTGVRTLAEQLEVGIATHIQKLIGVKESVLPE

PF10540 // ENSGT00730000110939_1_Domain_2 (1003, 1051)

DAI-LPLMKFLEVKLRYM
NTNLVQE---NFSSLLT--LLWTHTLTVLVEVASSQRSSLLASSRLKAALQNLEICFHAE
GCGLPPEALHTATFQALQRDLELQSASSRELIQKYFCSRIQQQAETTSEQLGAVTIKASY
RASEQ

PF00168 // ENSGT00730000110939_1_Domain_4 (1146, 1257)

KLRVELLSASSLLPLDSNGSSDPFVQLTLEPRHEFPELAPRETQKHKKELH----
---------PLFDETFEFLVPAEPCQKDWACLLLTVLDHDTLGADDLEGEAFLPLCRVPG
LTGCEE-----PGEAPQTRLPLTYPAPNG--------------------------DPILQ
LLDSRKGDREAQAFVKLRRQRAKQASQH---------------------APR--------
---------------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MATLLSHLQQRPPLLRQA----------------I-KIRR-----RRV--------RD
LQDPLPQTAPEIQPPSHHFSPEQRALLYEDALYTVLHRLGQPEPNHVTEASELLRYLQEA
FHVEPEEHQQA-L----QRVRELEKPIFC

PF00168 // ENSGT00730000110939_1_Domain_0 (270, 447)

LKATVKQAKGILGKDVSGFSDPYCLLGI-EQ
GVSVPGGSPGS-RHRQKAVVRHTIPEEQTHRTQVITQTLNPVWDETFILEFEDITNASFH
LDMWDLDTVESVRQKLGELTDLHG----------LRR--IFKEARKDKGQDDFLGNVVLR
-------------LQDLHCREDQWYPLEPRTETYPDRGQCHLQFQLIHKRR-ATSASRSQ
PSYTVHLHLLQQLVSHEVTQHQAGSTSWDGSLSPQAATVLFLHATQKDLSDFHQSMA-QW
LAYSRLYQSLEFPSSCLLHPITSIEYQWIQGRLKAEQQEELAASFSSLLAYGLSLIRRFR
SVFPLSVSDSPARLQSLLRVL--VQMCKMKAFGELCPNTAPLPQLVTEALQTGTTEWF--
---HLKQQHHQPMMQGILEAGKALLGLVQDVIGDLHQCQHTWDKIFHNTLKIHLFSMAFR
ELQWLV----AKRVQDHTT-AVGDAVSPEMGESLFQLYISLKELYQLRPSSS-------E
RDGVLALDNFH--RW-FQPAIPSWLQKTYNVALARVQRAVQMDELVPLGELTKHSTSA-V
DLSTCFAQISHTARQLDWPDPEEAFMITVKFVEDTCRLALVYCSLIKARARELSSGQKDQ
GQAANM----LCVVVNDMEQLRLVIGKLPTQLAWEALEQRVGAVLEQGQLQNTLHAQLQS
ALAGLGH-EIRTGVRTLAEQLEVGIAKHIQKLVGVRESVLPEDAI-LPLMKFLEVELCYM
NTNLVQE---NFSSLLT--LLWTHTLTVLVEAA

PF10540 // ENSGT00730000110939_1_Domain_3 (1054, 1114)

ASQRSSSLASNRLKIALQNLEICFHAE
GCGLPPEALHTATFQALQRDLELQAASSRELIR

ENSGT00730000110939_1_Linker_3_4 (1114, 1146)

KYFCSRIQQQADTTSEELGAVTVKACY
RASEQ

PF00168 // ENSGT00730000110939_1_Domain_4 (1146, 1260)

KLRVELLSASSLLPLDSNGSSDPFVQLTLEPRHEFPELAARETQKHKKDLH----
---------PLFDETFEFLVPAEPCRKAGACLLLTVLDYDTLGADDLEGEAFLPLCEVPG
LSGSEE-----PGEVPQTRLPLTYPAPNG--------------------------DPILQ
LLEGRKGDREAQVFVRLRRHR--------AKQGIG--PSVSWPICLLAFLFQPL---GWG
P---GSLEPGLQVQSLLGKGGG-PCQR------------

------------------------------------------------------------
------------------------------------------------------------
--MATHLSHPQRR-PLLRQAIKI-----------------RR-----R-----R--V-RD
LQDPPPQATQEVQVQSHHFSPEERDLLYEEALYTVLHRLGQPEPNHVKEASELLSYLQEA
FQVQPEEHQQML-----RRVRELEKPVFC

PF00168 // ENSGT00730000110939_1_Domain_0 (270, 447)

LKATVKQAKGILGKDVSGFSDPYCLLGI-EQ
KVGVAEGSPVS-RRRQKAVVKHTIPEEETHRTQVKSQTLNPVWDETFILEFEDIANASFH
LDMWDLDTVESVRQKLGELTDLHG----------LRR--IFKEARKDKGQDDFLGNVVLR
-------------LQDLRCREDQWFPLEPCTETYPDRGQCHLQFQFIHKRR-ATAASRSQ
PSYTVHFHLLQQLVSHEVTQHQAGSTSWDASLSPQAVTILFLHATQKDLSDFHQSMA-QW
LAYSRLYQSLEFPSSCLLHPITSIEYQWIQGRLKAEQREELATSFTSLLAYGLSLIRKFR
SVFPLSVSDSPSRLQSLLRVL--VQMCKMKAFGELCPDSAPLSQLVSEALRMGTVEWF--
---HLMQQHHQPM--GILEAGKALLNLVQDVMGDLYQCRRTWNKIFHNVLKIDLFSMAFL
ELQWLV----AKRVQDHTV-AAGNLVSPDIGESLFQLYVSLKELCQLGPVPSD------S
R-EVLALDGFH--RW-FQPAIPSWLQKTYSVALERVQRAVQMDTLVPLGELTKHSTSA-V
DLSTCFAQISHTARQLDWPDPEEAFMITVKFVEDTCRLALVYCSLIKARARELSAVQKDQ
SQAADM----LCVVVNNMEQLRLIIDKLPTQLAWEALEQRVGAVLEEGQLQNTLHAQLQG
ALAGLGH-EIRTGVRTLAEQLEVGIATHIQKLIGVKESVLPEDAI-LPLMKFLEVKLCYM
NTNLVQE---NFSSLLT--LLWTHTLTVLV

PF10540 // ENSGT00730000110939_1_Domain_3 (1051, 1114)

EVASSQRSSSLASGRLKVALQNLEVCFHAE
GCGLPPEALHTDTFQALQNDLELQAASSRELIQ

ENSGT00730000110939_1_Linker_3_4 (1114, 1146)

KYFCSRIQQQAETTSERLGAVTVKVSY
RASEQ

PF00168 // ENSGT00730000110939_1_Domain_4 (1146, 1257)

RLRVELLSASSLLPLDSNGSSDPFVQLTLEPRHEFPEVAPRETQKHKKELH----
---------PLFDETFEFLVPAEPCQKAWACLLLTVLDHDRLGADDLEGEAFLPLCRVPG
LTDCAE-----PGEAPQMRLPLTYPAPNG--------------------------DPILR
LLESRKGDREAQAFVKLRRQRAKQASQH---------------------AP---------
---------------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MATHLSHPQRR-PLLRQAIKI-----------------RR-----R-----R--V-RD
LQDPPPQATREVHVQSHHFSPEERDLLYEEALYTVLHRLGQPEPNHVKEDSELLSYLQKA
FQVQPEEHQQML-----RRVRELEKPVFC

PF00168 // ENSGT00730000110939_1_Domain_0 (270, 447)

LKATVKQAKGILGKDVSGFSDPYCLLGI-EQ
KVGVAEGSPVS-RRRQKAVVKHTIPEEETHRTQVKSQTLNPVWDETFILEFEDIANASFH
LDMWDLDTVESVRQKLGELTDLHG----------LRR--IFKEARKDKGQDDFLGNVVLR
-------------LQDLRCREDQWFPLEPCTETYPDRGQCHLQFQFIHKRR-ATAASRSQ
PSYTVHFHLLQQLVSHEVTQHQAGSTSWDASLSPQAVTILFLHATQKDLSDFHQSMA-QW
LAYSRLYQSLEFPSSCLLHPITSIEYQWIQGRLKAEQREELATSFTSLLAYGLSLIRKFR
SVFPLSVSDSPSRLQSLLRVL--VQMCKMKAFGELCPDSAPLSQLVSEALRMGTVEWF--
---HLMQQHHQPMVQGVLEAGKALLNLVQDVMGDLYQCRRTWNKIFHNVLKIDLFSMAFL
ELQWLV----AKRVQDHTV-AAGNLVSPDIGESLFKLYVSLKELYQLGPVPSD------S
R-EVLALDGFH--RW-FQPSIPSWLQKTYSVALERVQRAVQMDTLVPLGELTKHSTSA-V
DLSTCFAQISHTARQLDWPDPEEAFMITVKFVEDTCRLALVYCSLIKARARELSAVQKDQ
SQAADM----LCVVVNNMEQLRLIIDKLPTQLAWEALEQRVGAVLEQGQLQNTLHAQLQG
ALAGLGH-EIRTGVRTLAEQLEVGIATHIQKLIGVKESVLPE

PF10540 // ENSGT00730000110939_1_Domain_2 (1003, 1052)

DAI-LPLMKFLEVKLCYM
NTNLVQE---NFSSLLT--LLWTHTLTVLVEVASSQRSSSLASGRLKVALQNLEVCFHAE
GCGLPPEALHTDTFQALQNDLELQAASSRELIQKYFCSRIQQQAETTSERLGAVTVKASY
RASEQ

PF00168 // ENSGT00730000110939_1_Domain_4 (1146, 1257)

KLHVELLSASSLLPLDSNGSSDPFVQLTLEPRHEFPELAPRETQKHKKELH----
---------PLFDETFEFLVPAEPCQKAWACLLLTVLDHDRLGADDLEGEAFLPLCRVPG
LTDCAE-----PGEAPQMRLPLTYPAPNG--------------------------DPILR
LLESRKGDREAQAFVKLRRQRAKQASQH---------------------AP---------
---------------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MTTHLSHQQGRPPLLRQAIKI-----------------RR-----R-----R--V-RD
LQDPLPQTTQEVEAQPHHFSPEERDLLYEEALYTVLHRLGQPEPNHVKEASELLWYLQEA
FQVQPEEHQRML-----QRVRELEKPIFC

PF00168 // ENSGT00730000110939_1_Domain_0 (270, 447)

LKATVKQAKGILGKDVSGFSDPYCLLGI-EQ
GVGVSGGSPGS-RRRQKAVVRHTIPEEQTHRTQVISQTLNPVWDETFILEFEDITNASFH
LDMWDLDTVESVRQKLGELTDLHG----------LRR--IFKEARKDKGQDDFLGNVVLR
-------------LQDLRCREDHWYPLEPCTETYPDRGQCHLQFQFIHKRR-ATVASRSQ
PSYTVHLHLLQQLVSHEVTQHQAGSTSWDASLSAQATTILFLHATQKDLSDFHQSMA-QW
LAYSRLYQSLEFPSSCLLHPITSIEYQWIQGRLKAEQREELATSFTSLLAYGLSLIRKFR
SVFPLSVSDSPARLQSLLRVL--VQMCKMKAFGELCPNSAPLSQLVSEALRTGTVEWF--
---HLKQQHHQPMVQGILEAGKALLSLVQDIMGDLHQCRRTWNKVFHNALKIDLFSMAFL
ELQWLV----AKRVQDHTV-AVGSLVSPEMGESLFQLYVSLKELCQLGPAPSD------S
D-GPLALDGFH--RW-FQPAIPSWLQKTYSVALERVQRAVQMDTLVPLGELTKHSTSA-V
DLSTCFAQISHTARQLDWPDPEEAFMITVKFVEDTCRLALVYCSLIKARARELSAGQKDQ
GQAANM----LCVVVNDMEQLRLIIGKLPTQLAWEALEQRVGAVLEQGQLQNTLHAQLQG
ALAGLSH-EIRTGVRTLAEQLEVGIATHIQKLMGVKESVLPEDAI-LPLMKFLEVELCYM
NTNLVQE---NFSSLLT--LLWTHTLTVLVE

PF10540 // ENSGT00730000110939_1_Domain_3 (1052, 1114)

VATSQRNSSLASSRLKVALQNLEICFHAR
GFGLPPEALHTATFQALQRDLELQAASSRELIQ

ENSGT00730000110939_1_Linker_3_4 (1114, 1146)

KYFCSRIQQQAETTSEHLGAVTVKVSY
RASEQ

PF00168 // ENSGT00730000110939_1_Domain_4 (1146, 1258)

KLRVELLSASSLLPLDSNGSSDPFVQLTLEPRHEFPELAPRETQKHKKDLH----
---------PLFDETFEFLVPAEPCQKDGACLLLTVLDHDTLGTDDLEGEAFLPLCEVPG
LTGYEE-----PGEAPQTRLPLTYPAPNG--------------------------DPILQ
LLESRKGDREAQAFVKLRRQRAKQASQH---------------------ALQSGR-----
---------------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MATLLSHLQQRPPLLRQA----------------I-KIRR-----RRV--------RD
LQDPLPQTAPEIQPPSHHFSPEQRALLYEDALYTVLHRLGQPEPNHVTEASELLRYLQEA
FHVEPEEHQQA-L----QRVRELEKPVFC

PF00168 // ENSGT00730000110939_1_Domain_0 (270, 447)

LKATVKQAKGILGKDVSGFSDPYCLLGI-EQ
GVGVLGGSPGS-RHRQKAVVRHTIPEEQTHRTQVITQTLNPVWDETFILEFEDITSASFH
LDMWDLDTVESVRQKLGELTDLHG----------LRR--IFKEARKDKGQDDFLGNVVLR
-------------LQDLHCREDQWYPLEPRTETYPDRGQCHLQFQLIHKRR-ATSASRSQ
PSYTVHLHLLQQLVSHEVTQHQAGSTSWDGSLSPQAATILFLHATQKDLSDFHQSMA-QW
LAYSRLYQSLEFPSSCLLHPITSIEYQWIQGRLKAEQQEELAASFSSLLAYGLSLIRRFR
SVFPLSVSDSPARLQSLLRVL--VQMCKMKAFGELCPNTAPLPQLVTEALQTGTTEWF--
---HLKQQHHQPMVQGILEAGKALLGLVQDVIGDLHQCQRTWDKIFHNTLKIHLFSMAFR
ELQWLV----AKRVQDHTT-AVGDAVSPEMGESLFQLYISLKELCQLRPSSS-------E
RDGVLTLDNFH--RW-FQPAIPSWLQKTYNVALARVQRAVQMDELVPLGELTKHSTSA-V
DLSTCFAQISHTARQLDWPDPEEAFMITVKFVEDTCRLALVYCSLIKARARELSSGQKDQ
GQAANM----LCVVVNDMEQLRLVIGKLPTQLAWEALEQRVGAVLEQGQLQNTLHAQLQS
ALAGLGH-EIRTGVRTLAEQLEVGIAKHIQKLVGVRESVLPEDAI-LPLMKFLEVELCYM
NTNLVQE---NFSSLLT--LLWTHTLTVLVE

PF10540 // ENSGT00730000110939_1_Domain_3 (1052, 1114)

VAASQRSSTLASNRLKIALQNLEICFHAE
GCGLPPEALHTATFQALQSDLELQAASSRELIR

ENSGT00730000110939_1_Linker_3_4 (1114, 1146)

KYFCSRIQQQAETTSEELGAVTVKACY
RASEQ

PF00168 // ENSGT00730000110939_1_Domain_4 (1146, 1260)

KLRVELLSASSLLPLDSNGSSDPFVQLTLEPRHEFPELAARETQKHKKDLH----
---------PLFDETFEFLVPAEPCRKAGACLLLTVLDHDTLGADDLEGEAFLPLCEVPG
LSGSEE-----PGDVPQTRLPLTYPAPNG--------------------------DPILQ
LLAGRKGDREAQVFVRLRRHR--------AKQEKLLWWAGDRPICLLAFLFQPL---GWG
P---GSLEPGLQVQSPGEGRGTLPKRRLQL--P------

------------------------------------------------------------
------------------------------------------------------------
--MATLLSQPKRRPPLLRQAIKI-----------------RH-----RRG---R--V-GD
LQDPLPQRAQEIEPPSHHFSPEERALLYEEALYTVLHRLGQPEPNHVREASELLRYLQEA
FHMEPQEHQQML-----QQVQELEKPTFC

PF00168 // ENSGT00730000110939_1_Domain_0 (270, 379)

LKATVKQAKGILGKDVSGFSDPYCLLG-IEQ
GVGVPGGSPGS-RRRQKAVVRHTIPEEQTHRTQVVTQTLNPVWDETFILEFEDISNASFH
LDMWDMDTVESVRHKLGELTDLHG----------LRR--IFKEARKDKGQDDFLGNVVLR
-------------LQDLHCREDQWYPLEPCTETYPDRGQCHLQFQLIHKRR-ATEASRSQ
PSYTVHLHLLQQLVSHEVTQHQAGSTSWDGLLSPQAATILFLHATQKDLSDFHQSMA-QW
LAYSRLYQSLEFPSSCLLHPITSIEYQWIQGRLKAEQLEELAASFSSLLAYGLSLIRRFR
SVFPLSVSDSPARLQSLLRVL--VQMCKMKAFGELCPNSTPLPRLVTEALRTGTVEWF--
---HLKQQHHQPMVQGMLEAGKALLNLVQDIVGDLHQCQRTWNKIFHNALKIDLFSTAFL
ELQWLV----AKRVQDHTA-AVSGSVSPELGESLFQLYISLKELCQLGPIPS-------E
RDRALALDGFH--RW-FQPAIPSWLQKTYSVALARVQRAVQMDKLVPLGELTKHSTSA-V
DLSTCFAQISHTARQLDWPDPEEAFMITVKFVEDTCRLALVYCSLIKARARELSAGQKDQ
GQAANM----LCVVVNDMEQLRLVIGKLPTQLAWEALEQRVGAVLEQGQLQNTLHAQLQG
ALAGLGH-EIRTGVCTLAKQLEVGIATHIQKLVGIRESVLP

PF10540 // ENSGT00730000110939_1_Domain_3 (1002, 1115)

EDAI-LPLMKFLEVELCYM
NTNLVQE---NFSSLLT--LLWTHTLTVLTEVATSQRNCPLASRRLKVVLQNLEICFYAE
GCGLPPEALHTATFQALQRDLELQAASSQELIQK

ENSGT00730000110939_1_Linker_3_4 (1115, 1147)

YFCSRIQQQVETTSEELGAVTVKASY
SASEQK

PF00168 // ENSGT00730000110939_1_Domain_4 (1147, 1251)

LRVELLSASSLLPLDSNGSSDPFVQLTLEPRHEFPELAPRETQKHKKELH----
---------PLFDE-FEFLVPAEPCQKDGACLLLTVLDHDTLGADDLEGEAFLPLRSVPG
LTGTQE-----PGEVPQIRLPLTYPAPNG--------------------------DPILQ
LLESRKGDREAQVFVRLRRQRAKQASQH-----------------APQ----P-------
------RR-------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------QA
FGMNEEEHGAIM-----QQVMELESPIYC

PF00168 // ENSGT00730000110939_1_Domain_0 (270, 379)

LKATVKEAKGILGKDVSGLSDPYCLLGIEAR
SQEP---AHPDHKKRMKAVVKDLIPEDQIHRTQVINQTLSPVWNETFILEFKDVETASFH
LDMWDSDVVESMRHKLGELTDLHG----------LKR--IFKDARKDKGQDDFLGNVVVR
-------------LKDLHCWNDQWYQLEPRTETYPERGHCHLQFLLTHKKR-ATTSSRTQ
PSYTVHRHLLQQLVSHEILQHQAGSTSWDGELSSHASTVLYLHATQKDLSDFHQDMA-QW
LAYSKLYQSLEFNSSCLLHQITSIEYRWVQERLRPEQKAELAESFQSLLTYGVSLIRRFR
IIFPLSVPRSTERLQSLLRVL--VQMCKTKAFRELCTPSPDLAQMISTALKSGTAEWF--
---HMQKQHLKPMVKSIEENSKALSKLLLEVIEDLKQCQKIWNKLFSTNLKLNIFSIAYL
ELESLV----AEHVQQQLH-KVDSSMSRPTAESLFDLYRKLQELCQMKDSLP-------S
RDGPLALSNFH--QW-FEEALPLWLQKAYSTALERAQRAIQMDQLKPYGYH-KHSTST-V
DLSTCYAQIVTTWKQLNWPDPEKAFMIMVNLLEDMCKISLMYCKLIKERAEALSLREQNE
GEAANKVGVGLCIVVNNIEQLRLLMLRLPSQLDWAQLERRMRGLIDPQQIQNALHNQLDS
TVACLDH-EVRDVVQALATKLEKGIARHIQELSSSSDTQKP

PF10540 // ENSGT00730000110939_1_Domain_3 (1002, 1115)

EDSI-IPLMKFLESELQYL
NEHLVQE---NFKSLLT--LLWHHTLSVLSAAQGPQVPSLQHCQRLFCALKSLELCFHAE
GCGLPLETLHSATFRTLETHLALCSATSRKLIQK

ENSGT00730000110939_1_Linker_3_4 (1115, 1147)

YFSNRIQQQLDTSSEKYGAVTIKALY
RPSEQK

PF00168 // ENSGT00730000110939_1_Domain_4 (1147, 1251)

LRVEVLNATNLIPLDSNGSSDPFVQLTLEPRHEFPEVVARSTQCKRNELH----
---------PLFDEAFDFLIPSEKCRQEGACLLLTVFDYDMLGANDLEGEAFFPLCHLPG
LDTEED--EADMGRVPQTRLPLTHPKPTG-------------------------------
------------------------------------------------------------
---------------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MATLFSRPQRRPPLLRQAIKI-----------------RR-----R-----G--V-RD
LQDPRPPRAQEIEPSSHHLLPEERALLYEEALYTVLYRLGQPEPNHVGESSELLRYLQEA
FRMEPEEHQQML-----KRVQQLEKPVFC

PF00168 // ENSGT00730000110939_1_Domain_0 (270, 447)

LKATVKQAKGILGKDVSGFSDPYCLLG-IEQ
GMTVSGGSPGL-RRRQKAVVRHTIPEEQTHRTQVITQTLNPVWDETFILEFEDISNASFH
LDMWDMDAVESVRQKLGELTDLHG----------LRR--IFKEARKEKGQDDFLGNVVLR
-------------LQDLRCREDHWYPLEPCTDTYPDRGQCHLQFQFIHKRR-ATKASRSQ
PSYTVHLHLLQQLVSHEVTQHQAGSTSWDGSLSSQAATILFLHATQKDLSDFHRSLA-QW
LAYSRLYQSLEFPSSCLLFPITSIEYQWIQGRLKAEQLEELATSFSSLLAYGLSLIRRFR
SVFPLSVPDSPARLQSLLRVL--VQMCKMKAFGELCPDSAPLPSLVTEALRAGTVGWF--
---HLKQQHHQPMVQGLLEMGKALLSLVQDIIGDLHQCQRTWNKIFHNVLKIDLFSMAFL
ELQWL----VAKRVQDYIA-MVGGSVTPELGESLFQLYVSLKELYQLGP-----------
-DGVLALEGFH--RW-FQPAIPSWLQKTYSVALARVQRAVQMDQLVPLGELTKHSTSA-V
DLSTCFAQISHTARQLNWPDPEEAFMITVKFVEDTCRLALVYCSLIKARAQELSAGQKDQ
GQAANM----LCVVVNDMEQLRLVIGKLPTQLAWEALEQRVGAVLEQEQLQNTLHAQLQG
ALAGLGH-EIRTGVRTLAKQLEAGIAKHIQKLVGIRESVLPE

PF10540 // ENSGT00730000110939_1_Domain_2 (1003, 1051)

DAI-LPLMKFLEVKLCYM
NTNLVQE---NFSSLLS--LLWTHTLSVLAEVAASQRSCPLACSRLKFALQNLEICFYAE
GCGLPPEALHTATFQALQRDLELQAASSRELVSKYFCCRLEQQAATTSEELGAVTVKASY
RPSEQ

PF00168 // ENSGT00730000110939_1_Domain_4 (1146, 1257)

KLRVELLSASNLLPLDSNGSSDPFVQLTLEPRHEFPELAPRETQKHKKDLH----
---------PLFDETFEFLVPAEPLQKDGACLLLTVLDHDRLGTDDLEGEAFLPLRSVPG
LTGMEE-----PGEVPQTRLPLTYPAPNG--------------------------DLILQ
LLESRKGDREAQAFVRLRRQRAKQA--------------------SHQHSLQP-------
------GR-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MATHLSHPQRR-PLLRQAIKI-----------------RR-----R-----R--V-RD
LQDPPPQATQEVQVQSHHFSPEERDLLYEEALYTVLHRLGQPEPNHVKEASELLSYLQEA
FQVQPEEHQQML-----RRVRELEKPVFC

PF00168 // ENSGT00730000110939_1_Domain_0 (270, 447)

LKATVKQAKGILGKDVSGFSDPYCLLGI-EQ
KVGVAEGSPVS-RRRQKAVVKHTIPEEETHRTQVKSQTLNPVWDETFILEFEDIANASFH
LDMWDLDTVESVRQKLGELTDLHG----------LRR--IFKEARKDKGQDDFLGNVVLR
-------------LQDLRCREDQWFPLEPCTETYPDRGQCHLQFQFIHKRR-ATAASRSQ
PSYTVHFHLLQQLVSHEVTQHQAGSTSWDASLSPQAVTILFLHATQKDLSDFHQSMA-QW
LAYSRLYQSLEFPSSCLLHPITSIEYQWIQGRLKAEQREELATSFTSLLAYGLSLIRKFR
SVFPLSVSDSPSRLQSLLRVL--VQMCKMKAFGELCPDSAPLSQLVSEALRMGTVEWF--
---HLMQQHHQPMVQGVLEAGKALLNLVQDVMGDLYQCRRTWNKIFHNVLKIDLFSMAFL
ELQWLV----AKRVQDHTV-AAGNLVSPDIGESLFQLYVSLKELCQLGPVPSD------S
R-EVLALDGFH--RW-FQPAIPSWLQKTYSVALERVQRAVQMDTLVPLGELTKHSTSA-V
DLSTCFAQISHTARQLDWPDPEEAFMITVKFVEDTCRLALVYCSLIKARARELSAVQKDQ
SQAADM----LCVVVNNMEQLRLIIDKLPTQLAWEALEQRVGAVLEEGQLQNTLHAQLQG
ALAGLGH-EIRTGVRTLAEQLEVGIATHIQKLISVKESVLPE

PF10540 // ENSGT00730000110939_1_Domain_3 (1003, 1114)

DAI-LPLMKFLEVKLCYM
NTNLVQE---NFSSLLT--LLWTHTLTVLVEVASSQRSSSLASGRLKVALQNLEVCFHAE
GCGLPPEALHTDTFQALQNDLELQAASSRELIQ

ENSGT00730000110939_1_Linker_3_4 (1114, 1146)

KYFCSRIQQQAETTSERLGAVTVKASY
RASEQ

PF00168 // ENSGT00730000110939_1_Domain_4 (1146, 1257)

RLRVELLSASSLLPLDSNGSSDPFVQLTLEPRHEFPELAPRETQKHKKELH----
---------PLFDETFEFLVPAEPCQKAWACLLLTVLDHDRLGADDLEGEAFLPLCRVPG
LTDCAE-----PGEAPQMRLPLTYPAPNG--------------------------DPILR
LLESRKGDREAQAFVKLRRQRAKQASQH---------------------AP---------
---------------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MATLFPHSQRRPPLLRQAIKI-----------------RR-----R-----R--V-RD
LQDPLPPRAQEVETPSHHFSSEERALLYEEALYTVLYRLGQPEPNHVGESSELLRYLQEA
FHMEPEEHLQML-----QQVQELEKPVFC

PF00168 // ENSGT00730000110939_1_Domain_0 (270, 447)

LKATVKQAKGILGKDVSGFSDPYCLLAIIEQ
GAAVPGGSPGP-RRRQKAVVRHTIPEEQTHRTQVITQTLNPVWDETFILEFGDINNASFH
LDMWDLDTVESVRQKLGELTDLHG----------LRR--IFKEARKDKGQDDFLGNVVLR
-------------LQDLHCREDQWYPLEPCTETYPDRGQCHLQFQFIHKRR-ATVASRSQ
PSYTVHLHLLQQLVSHEVTQHQAGSTSWDGSLSAHAATILFLHATQKDLSDFHRSLA-QW
LAYSRLYQSLEFPSSCLLYPITSIEYQWIQGRLKAEQLEELATSFNSLLAYGLSLIRRFR
SVFPLSVSDSPARLQSLLRVL--VQMCKMKAFGELCPDSTPLPQLVTEALRTGTVEWF--
---HLKQQHHQPMVQGLLEAAKALLSLVQDITGDLHQCQRTWNKIFHNVLKIDLFSVAFQ
ELQWLV----AKRVQDHTA-AMGDAVTPEIGESLFQLYVSLKDLCRLGPVPS-------E
RDGVLALDGFH--RW-FQPAIPSWLQKTYSVALARVQRAVQMDKLVPLGELTKHSTSA-V
DLSTCFAQISHTARQLDWPDPEEAFMITVKFVEDTCRLALVYCSLIKARARELSAGQKDQ
GQAANM----LCVVVNNMEQLRLVIGKLPTQLAWEALEQRVVAVLEQGQLQNTLHAQLQS
ALAGLGH-EIRTGVRTLAEQLEVGIAKHIQKLVGIKESVLPEDAI-LPLMKFLEVELCYM
NTNLVQE---NFSSLLT--LLWTHTLMVLAE

PF10540 // ENSGT00730000110939_1_Domain_3 (1052, 1114)

VAASQRSCPLASRRLKIALQNLEICFYAE
GCGLPPEALHTATFQALQRDLELQAASSRELIQ

ENSGT00730000110939_1_Linker_3_4 (1114, 1146)

KYFCSRIQQQAETASEELGAVTVKASY
RASEQ

PF00168 // ENSGT00730000110939_1_Domain_4 (1146, 1257)

KLRVELLSASSLLPLDSNGSSDPFVQLTLEPRHVFPELAPRETQKHKKDLH----
---------PLFDETFEFLVPAEPCRKDGACLLLTVLDHDTLGADDLEGEAFLPLHSVPG
LTGTEE-----PGEVPQTRLPLTYPAPNG--------------------------DPVLQ
LLESRKGDREAQGFVRLRRQRAKQASQH-----------------PPP----G-------
------R--------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MATRLSCPQRRPPLLRQAIKI-----------------RR-----R-----K--V-QD
LPDPLAQMTQEVKPASHHLSPKERDLLYEEALYTVLHRLGQPEPSHVVEASELLRYLQEA
FQMQPEEHQRML-----QQARELKKPIFC

PF00168 // ENSGT00730000110939_1_Domain_0 (270, 447)

LKATVKQAKGILGKDVSGFSDPYCLLGI-EQ
GVGMPGGSPGS-RRRQKAVVRHTIPEEQTHRTQVISQTLNPVWDETFILEFEDIANASFH
LDMWDMDTVESVRQKLGELTDLHG----------LRR--IFKEARKDRGQDDFLGNVVLR
-------------LQDLRCREDQWYPLEPRTETYPDRGQCHLQFQLIHKRR-ATAASRSQ
PSYTMHLHLLQQLVSHEVTQHKVGSTSWDGSLSPQATTILFLHAMQKDLSDFHQSLA-HW
LAYSHLYQSLEFPSSCLLHPITSIEYQWIQGRLKPEQLEELTTSFTSLLAYGLSLIRRFR
SVFPLSVSDSPARLQSLLRVL--VQMCKMKAFGELCQNSTPLPQLVTEALRTGTVEWF--
---HLKQQHHQPMVQGMLEAGKALLSLVQDVLGDLHQCQRTWNKIFHNSLKIDLFSMVFL
ELQWLV----AKRVQDHTS-AVGSPVSPEMAESLFQLYVSLKELCQLGPVPAD------R
D-GVLALDGFH--RW-FQPAIPSWLQKTYSVALERVQRAVQMDKLVPLGELTKHSTSA-V
DLSTCFAQISHTAQQLDWPDPEEAFMITVKFVEDTCRLALVYCSLIKARARALSAGQKDQ
GQAADM----LCVVVNDMEQLRLVIGKLPTQLAWQALEQRVGTVLEQGQLQNTLHTQLQS
ALAGLGH-EIRTGVQTLAEQLEVGIARHIQKLVDVKESVLPE

PF10540 // ENSGT00730000110939_1_Domain_2 (1003, 1051)

DAI-LPLMKFLEVKLCYM
NTNLVQE---NFSSLLT--LLWTHTLTVLVEAAASQRSSTLASGRLKVALQNLEICFHAE
GCGLPPEALHTATFQALQRDLELQAASSRELIRKYFCSRIQQQAETTSEWLGAVTVKASY
RSSEQ

PF00168 // ENSGT00730000110939_1_Domain_4 (1146, 1257)

KLHVELLSASSLLPLDSNGSSDPFVQLTLEPRHEFPELAPRETQKHKKDLH----
---------PLFDETFEFLVAAEPCRKDGACLLLTVLDHDTLGANDLEGEAFLPLCAVPG
LTGCEE-----PGEAPQTRLPLTYPMPNG--------------------------DPILQ
LLEGRKGDREAQAFVRLRRQRAKQASQH---------------------PPRPGQ-----
---------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------TTQETEPPSHHLPPEERALLYEEALYTVLHRLGQPEPDHVSEASELLHYLQEA
FHIEPQEHEQLL-----RRVQELEKPTFC

PF00168 // ENSGT00730000110939_1_Domain_0 (270, 405)

LKATVKQAKGILGKDVSGLSDPYCLLGI-EQ
GVGVPGGSPTS-RRKQKAVVRDTIPEDQTHRTQVITQTLNPVWDETFILEFEDIASASFH
LDMWDLDVESV---------------------------RKLGEL

ENSGT00730000110939_1_Linker_0_1 (405, 643)

TDLHGLRXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-QW
LAYSRLYQSLEFPSSCLLHPITSIEYQWIQGRLRAEQLEELATSFSSLLAYGLALIRKFR
SVFPLSIPDSPARLQSLLRVL--AQMCKTKAFGELCLDSPPL

PF06292 // ENSGT00730000110939_1_Domain_1 (643, 722)

SQLVTEALQTGTVEWF--
---HLKQQHHQPMVQGVLEAGKALLGLVQDVLGDLHQCLRTWNKIFHNVLRIDLFSTAFW
ELQGLV----AKQAQDHMA-TVCSPVSPEVGESLFQLYVSLKELCQLGPLPS-------E
RDRVPALDGFH--CW-FQPAIPSWLQKTYSVALERVQRAVQMDQL---------------
---------------------------------DTCRLALVYCSLIKARARELSAGQKDQ
SQAADM----LCVVVNNMEQLRLVIDRLPSQLAWEALEQRVGAVLEQGQLQNTLHAQLQS
ALAGLGH-EIRTGVRTLAEQLEAGIAMHIQKLVSVRDSVLPEDAI-LPLMKFLEVKLCYM
NTNLVQE---NFSSLLS--LLWTHTLVVLVEAATAQRSCPLASCRLKTALQNLEICFHAE
GCGLPPDALHTATFQALQRDLELQAASSRELIQKYFCSRIRQQAETTSEALGAVTVKASY
RVAEQK

PF00168 // ENSGT00730000110939_1_Domain_4 (1147, 1252)

LRVEILSASSLLPLDSNGSSDPFIQLTLEPRHEFPELAPRETQKHRKELH----
---------PLFDETFEFLVPAEPCQKDGACLLLTVLDHDTLGADDLEGEAFLPLCSVPG
LSGSEE-----PSEVPQTRLPLTYPEPNG--------------------------DPILQ
LLESRKGDREAQVFVRLRRLRAKQASQHPLQSGR--------------------------
---------------------------------------

------------------------------------------------------------
---------------------------------------------MEPHE----------
--------NDGDSPPSENKDLEMEPQP-----VRRGF---TRREAKYRKKGTVRTQQGQS
VKE------PDIESK-PLSQSAQRNLLYGEALYTIIHRMGMPEPEHIYNEEQLYDYLQKA
FNMDPGEHEAIL-----QRVRGLEAPIRC

PF00168 // ENSGT00730000110939_1_Domain_0 (270, 418)

LKVTVKEAKGILGKDVSGFSDPYCLLGIDHR
SSGRSRDSSPDRKQKQKAVVRNTIPEDRMHRTQIIGQTLNPVWNETFILEIEDMEKASFQ
MDMWDSDDVETVRTKLGDLTDLHG----------LKR--IFKEARKDKGQDDFLGNVVLQ
-------------LRGLKCKEDCWYNLEPRTETYPERGRCHLQFLLTHKKRGTM--LTKT
PSYIVHRQLLQQFVRHEITRHEATNITWNGEISPHGATILYLHATQKDLSEFHQGLA-QW
LAYSKLYQSMEFSSSCLLHHITSIEYLWVQGRLQDEQKAELAESFESLLVYGVSLLQRYR
IVFPLSAPRSVERLQSLLRVL--IQMCKTKAFRELCSLTPDLQERVTEAIKAGTHEWF--
---DLKRQHLQPMIQNQEENLKSLVRLVSDVTSDLQSCHKTWNKCFINTIKVDIFSLTFQ
ELEELV-SQ---HLLSQL-PSLKLSSSPQLSEILYQLYLTLRELHKLHVHMA-------K
SENDLPLSGFH--RW-FAESLPSWLQRAYTTAQERVQRAVQIDQLVPLSELQKHSAST-V
DLSTCYSQIGKTWQQLDWPDPEEAFMIMVKFTEDMCRIALTYCSLIKRRAEEIS-GNKDA
AEAASK----LCLVVNNIEQLRLVVRSLPTKLDWESLEQKTSHVISTDQFQHTLHDQLRG
AIVCLDR-EIRGVVQSLAQKLDAGIAKHLYSLASVNDFKDPNDSI-IPLMKFLENELQYM
NQNLVQE---NFNCLLS--LLWSHILIVISGLSTQVTPSSRYYQRLHAAL-KVKSCVYSS
PCSPIRVSHSVEYCCAYGLALNFWKNATLHSLNHWFPNSFPNQNECTSEKYGAVTVKASY
RSSEQK

PF00168 // ENSGT00730000110939_1_Domain_4 (1147, 1252)

LRVEILNAVNLLPLDSNGSSDPFVQLTLEPKHLFPAVELRSTQIKKNELN----
---------PLYDETFDFLVAAEQCKGAGACLLLTVFDYDTLRSNDFEGEAFLALSSLPG
LQEKKTEEGGLVANIPQTRLPLIHPKPNG--------------------------DRILQ
ILESRRSDREAVAFVKLRRQRARQSLEGKR------------------------------
---------------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MATLFSRPQRRPPLLRQAIKI-----------------RR-----R-----G--V-RD
LQDPRPPRAQEIEPSSHHLSPEERALLYEEALYTVLYRLGQPEPNHVGESSELLRYLQEA
FRMEPEEHQQML-----KRVQQLEKPVFC

PF00168 // ENSGT00730000110939_1_Domain_0 (270, 379)

LKATVKQAKGILGKDVSGFSDPYCLLG-IEQ
GMTVSGGSPGL-RRRQKAVVRHTIPEEQTHRTQVVTQTLNPVWDETFILEFEDISNASFH
LDMWDMDAVESVRQKLGELTDLHG----------LRR--IFKEARKEKGQDDFLGNVVLR
-------------LQDLRCREDHWYPLEPCTDTYPDRGQCHLQFQFIHHPQRATKASRSQ
LLGPGGARACLQGPDTPHLPPQAGSTSWDGSLSSQAATILFLHATQKDLSDFHRSLA-QW
LAYSCLYQSLEFPSSCLLFPITSIEYQWIQGRLKAEQLEELASSFSSLLAYGLSLIRRFR
SVFPLSVPDSPARLQSLLRVL--VQMCKMKAFGELCPDSAPLPSLVTEALRAGTVGWF--
---HLKQQHHQPMVQGLLEMGKALLSLVQDIIGDLHQCQRMWNKIFHNVLKIDLFSMAFL
ELQWFP-PQVAKRVQDYIA-MVGGSVTPEVGESLFQLYVSLKELYQLGPHPS-------E
RDGVLALEGFH--RW-FQPAIPSWLQKTYSVALARVQRAVQMDQLVPLGELTKHSTSA-V
DLSTCFAQISHTARQLDWPDPEEAFMITVKFVEDTCRLALVYCSLIKARAQELSAGQ-DQ
GQAANM----LCVVVNDMEQLRLVIGKLPTQLAWEALEQRVG------------------
----AGN-EIRTGVRTLAKQLEAGIAKHIQKLVGIRESVLP

PF10540 // ENSGT00730000110939_1_Domain_3 (1002, 1115)

EDAI-LPLMKFLEVKLCYM
NTNLVQE---NFSSLLS--LLWTHTLSVLAEVAASQRSCPLACSRLKFALQNLEICFYAE
GCGLPPEALHTATFQALQRDLELQAASSRELVSK

ENSGT00730000110939_1_Linker_3_4 (1115, 1147)

YFCCRLEQQP---SEELGAVTAKASY
RPSEQK

PF00168 // ENSGT00730000110939_1_Domain_4 (1147, 1251)

LRVELLSASNLLPLDSNGSSDPFVQLTLEPRHEFPELAPRETQKHKKDLH----
---------PLFDETFEFLVPAEPCQKDGACLLLTVLDHDRLGTDDLEGEAFLPLRSVPG
LTGMEE-----PGEVPQTRLPLTYPAPNG--------------------------DLILQ
LLESRKGDREAQAFVRLRREGAQHASLA-----------------SPQTALQP-------
------GR-------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------MDLSHKFTRKELTLLYEEVLYTILHRLGKPDPNHVADPDELYAYVQKV
FGMDPDEHRIIL-----QRVKELEKPMFC

PF00168 // ENSGT00730000110939_1_Domain_0 (270, 379)

LKATVKQARGILGKDASGLSDPYCLLGLETK
KRDSSSNGNQGNKKRAKAVVKNLIPEDQTHRTQIISQTLNPVWDETFILEFEDIANARFH
LDMWDSDEVETVRQKLGEVTDLHG----------LKR--IFKEARKDKGQDDFLGNVVLH
-------------LQDLHCRDDRWYKLEPRTETYPNRGHCHLQFLLIHKKR-ATSASKMQ
PNYIVHRHLLQQMVSYEILQHQAGSTSWDGELSKHANTILHLHATQKDLSDFHQDMA-HW
LAYSKLYQILEFNSNCLLHYITSIEYQWVEGRLRPVQQTELTDSFQSFLAYGLSVLRRYR
IVFPFSAPKSKERLQSLLRVL--VQMCKMKAFREFMQ-TSDLQQMVKESLKAGTEEWF--
---QMKKQHLKPMVKTTEECGKALVDLLAEVNADLQQCLKMWNKCFISTMRVDLFSIAYL
EMQELV----SFYVQKQLS-EIDSGVSQLTAESLFQLYLSLQELYRLKDFVS-------N
RESPLELANFH--QW-FKELIPKWLQKAYTIALERTQRAVQVDQLMPLGEMNKHSTST-V
DLSTCYAQMVKTWQQLDWPDPEEAFMIMVKFVEDMCKIALMYCRLLKQRAEELSSNQREE
GEAANK----LCVVVNDIEQLRIMILKLPSQLDWSRLEQKTREVIAPEQFQNTLHHQLQA
TVTCLNN-EIRSVVQTLGTKLDAGIARHIQELSASSDSKDP

PF10540 // ENSGT00730000110939_1_Domain_3 (1002, 1115)

EDSI-IPLMKFLECELQYL
NVNLVQE---NFNSLLG--MLWNHTLELLKGAAKQKTSNLRYFRKLQFALQSLELCFHAE
GCGLPKDTLHTTTFMALEKELDLCSSSSKRLIQK

ENSGT00730000110939_1_Linker_3_4 (1115, 1147)

YFSARIQQQMEAKPDKYGAVTIKALY
RHSEQK

PF00168 // ENSGT00730000110939_1_Domain_4 (1147, 1251)

LHIEVLNAVNLLPLDSNGSSDPFIQLTLEPRHEFPEVVARTTQCIKNNLH----
---------PLFDEVFEFLVPPEKCQQDGSCLLLTVFDYDTLGANDLEGEAFLPLCGVLG
LNDMEE--TINPSAVPQTRLSLTHPGTAG--------------------------NDILQ
ILEIRKGDKEAQAFVKLRRQRTKQSKE---------------------------------
---------------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MATLLSRPQQRPPLLRQA----------------I-KIRR-----RRV--------RD
-QDPPPQMAPEIHPPSHHFSPKQRALLYEDALYTVLHRLGQPEPNHVTEASELLRYLQEA
FHVEPEEHWQTL-----QRVRELEKPIFC

PF00168 // ENSGT00730000110939_1_Domain_0 (270, 447)

LKATVKQAKGILGKDVSGFSDPYCLLGI-EQ
RVGGPGGSPGS-RQRQKAVVRHTIPEEQTHRTQVITQTLNPVWDETFILEFEDITNARFH
LDMWDLDTVESVRQKLGELTDLHG----------LRR--IFKEARKDKGQDDFLGNVVLR
-------------LQDLRCREDQWYPLEPCTETYPDRGQCHLQFQLIHKRR-ATAASRSQ
PSYTVHLHLLQQLVSHEVTQHEAGSTSWDGSLSPQAATVLFLHATQKDLSDFHQSMA-QW
LAYSRLYQSLEFPSSCLLHPITSIEYQWIQGRLKAKQQEELAASFSSLLAYGLSLIRRFR
SVFPLSVSDSPARLQSLLRVL--VQMCKMKAFGELCPNTAPLPQLVTEALPAPGPGNPSL
LTASLSTDCPPLSLQGILEAGKALLGLVQDIIGDLHQCQRTWDKIFHNTLKIHLFSMVFR
ELQWLV----SPSPVSRA--------------------------C---------------
------------------PPTEL-----------WDPRAVQIDELVPLGELTKHSTSA-V
DLSTCFAQISHTARQLDWPDPEEAFMITVKFVEDTCRLALVYCSLIKARARELSSGQTDQ
GQAANM----LCVVVNDMEQLRLVIGKLPAQLAWEALEQRVGGVLEQGQLQNTLHAQLQS
ALAGLGH-EIRTGVRTLAEQLEVGIAKHIQKLVGVRESVLPEDAI-LPLMKFLEVELCYM
NTNLVQE---NFSSLLT--LLWTHTLTVLVEAA

PF10540 // ENSGT00730000110939_1_Domain_3 (1054, 1114)

ASQRSSSLASNRLKIALQNLEICFHAE
GCGLPPEALHTATFQALQRDLELQAASSRELIR

ENSGT00730000110939_1_Linker_3_4 (1114, 1146)

KYFCSRIQQQAETTSEELGAVTVKASY
RASEQ

PF00168 // ENSGT00730000110939_1_Domain_4 (1146, 1260)

KLRVELLSASSLLALDSNGSSDPFVQLTLEPRHEFPELAARETQKHKKDLH----
---------PLFDETFEFLVPAEPCRKPGACLLLTVLDYDTLGADDLEGEAFLPLCEVPG
LSGSEE-----PGEVPQTRLPLTYPAPNG--------------------------DPVLQ
LLEGRKGDREAQVFVRLRRHRA----------KQLLWWAGDWAICLLAFLFQPL---GWG
PGSLG---PGLQAQSPGEGRGDPAKDEAPA--ALGGGWW

------------------------------------------------------------
------------------------------------------------------------
--MATLLSHPQQRPPFLRQA----------------I-KIRR-----QRV--------KD
LQDPLPQTAPEIQPPSHHFSPEQRAQIYEDALYTVLHRLGQPEPNHVTEASELLRYLQEA
FHVEPEEHQQAL-----QRVRELEKPTFC

PF00168 // ENSGT00730000110939_1_Domain_0 (270, 447)

LKATVKQAKGILGKDVSGFSDPYCLLGI-EQ
GVGAPGGSPGS-RRRQKAVVKHTIPEEQTHRTQVVTQTLNPVWDETFILEFEDITNSSFH
LDMWDLDTVESVRQKLGELTDLHG----------LRR--IFKEARKDKGQDDFLGNVVLR
-------------LQDLRCREDQWYPLEPRTETYPDRGQCHLQFQLIHKRR-ATLASRSQ
PSYTVHLHLLQQLVSHEVTQHQAGSTSWDGSLSPQAATVLFLHATQKDLSDFHQSMA-QW
LAYSRLYQSLEFPSSCLLHPITSIEYQWIQGRLKAEQEEELAASFSSLLAYGLSLIRRFR
SVFPLSVSDSPARLQSLLRVL--VQMCKMKAFRELCPNTAPLPQLVTEALQTGTTEWF--
---HLKQQHHQPMMQGMLEAGKALLGLVQDIIGDLHQCQRTWDKIFHNALKIHLFPMAFR
ELQWLV----AKRVQDHTT-AVGDAVSPEMGESLFQLYITLKELCQLCPSSS-------E
RDGVLALESFH--RW-FQPAIPSWLQKTYSVALARVQRAVQMDELVPLGELTKHSTSA-V
DLSTCFAQISHTARQLDWPDPEEAFMITVKFVEDTCRLALVYCSLIKARARELSSGQKDQ
AQAANM----LCVVVNDMEQLRLVIGKLPAQLAWEALEHRVGAVLEQGQLQNTLHAQLQS
ALAGLGH-EIRTGVHTLAEQLEVGIAKHIQKLVGIRESVLPE

PF10540 // ENSGT00730000110939_1_Domain_2 (1003, 1052)

DAI-LPLMKFLEVELCYM
NTNLVQE---NFSSLLT--LLWTHTLTVLEEVAASQRSSSLASKRLKIALQNLEICFHAE
GCGLPPEALHTATFQALQRNLELQAASSRELIRRYFCGRIQQQSETISEELGAVTVKASY
RTSEQ

PF00168 // ENSGT00730000110939_1_Domain_4 (1146, 1260)

KLHVELLSASSLLPLDSNGSSDPFVQLTLEPRHDFPELAARETQKHKKDLH----
---------PLFDETFEFLVPAELCRKPGACLLLTVLDYDTLGADDLEGEAFLPLCEVHG
LSGSEE-----PGEVPQTRLPLTYPAPNG--------------------------DPILQ
LLEGRKGDREAQVFVRL-RR--QRAKQGIW------------PSVSW-FLFHLL---GWG
PGSLGAGLQAQSLLG--KGQGTLPKMRLQLSWGEGGDRY

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------TQSPSHHFSPEERALLYEEALYTILHRLGQPEPNHVMEVSELLRYLQEM
PRPKDTHQXXXX-----XXXXXXXXXXXXXXXXXXX--XXXXXXXXXXXXXX--XXX-XX
XXXXXXXXXXX-X---XXXXXXXX-XX-XX-X-XXX-X-XXXXXXXXX-XX-XXXXXXX-
-XXXXXXXXXXXXXXXX-X------------------XXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXDLRCREDRWYPLEPCTETYPDRGQCHLQFQFIHKRR-ATRASRSQ
PSYRVHLHLLQQLVSHEVTKHQAGSTSWDGSLSPQAATILFLHAMQKDLSDFHQSMA-QW
LAYSRLYQSLEFPSSCLLHPITSIEYQWIQGRLKEEQXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--
---XXXXXXXXAV

PF06292 // ENSGT00730000110939_1_Domain_1 (674, 722)

VQGLLEAGKALLSLVQDVTGDLHQCQRTWNKIFHNTLKVDLFSTAFL
ELQWLV----AKRVQDHTV-TVGSQVSPEMGESLFQIYISLKEFCQLGPNPS-------E
RDGALALDGFH--RW-FRPAIPSWLQKTYSVALARVQRAVQMDQLVPLGELTKHSTSA-V
DLSTCFAQISHTARQLDWPDPEEAFMITVKFVEDTCRLALVYCSLIKARARELSAVQKDQ
GQAANM----LCVVVNDMEQLRLVIDRLPAQLGWEALEQRVSAVLAQEQLQHTLHAQLQG
ALAGLGH-EIRTGVCTLAQXXXXXXXXXXX-XXXXXXXXXXXXTV-VPLMKFLETELCYM
NTNLVWE---NFSSLLT--LLWTHTLTVLAEAATSQRTSPLASSRLKAALQKLEISFHAD
GCGLRT---------ALQKDLELQAASSRQLIRLYFCRRLEQQAETTSEELGVVTVKASY
RSSEQK

PF00168 // ENSGT00730000110939_1_Domain_4 (1147, 1252)

LHVELLSASSLLPLDSNGSSDPFVQLTLEPRHVFPELAPRETQKHKKDLH----
---------PLFDETFEFLVPAEPCQEEGACLLLTVLDHDTLGADDLEGEAFLPLRSVRG
LPGAEE-----PREVPQTRLPLTYPAPNG--------------------------DPILQ
LLESRKGDREAQAFVRVRKKRAKQAAQHAPRGR---------------------------
---------------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MATLLSHLQQRPPLLRQA----------------I-KIRR-----RRV--------RD
LQDPLPQTAPEIQPPSHHFSPEQRALLYEDALYTVLHRLGQPEPNHVTEASELLRYLQEA
FHVEPEEHQQA-L----QRVRELEKPIFC

PF00168 // ENSGT00730000110939_1_Domain_0 (270, 447)

LKATVKQAKGILGKDVSGFSDPYCLLGI-EQ
GVSVPGGSPGS-RHRQKAVVRHTIPEEQTHRTQVITQTLNPVWDETFILEFEDITNASFH
LDMWDLDTVESVRQKLGELTDLHG----------LRR--IFKEARKDKGQDDFLGNVVLR
-------------LQDLHCREDQWYPLEPRTETYPDRGQCHLQFQLIHKRR-ATSASRSQ
PSYTVHLHLLQQLVSHEVTQHQAGSTSWDGSLSPQAATVLFLHATQKDLSDFHQSMA-QW
LAYSRLYQSLEFPSSCLLHPITSIEYQWIQGRLKAEQQEELAASFSSLLAYGLSLIRRFR
SVFPLSVSDSPARLQSLLRVL--VQMCKMKAFGELCPNTAPLPQLVTEALQTGTTEWF--
---HLKQQHHQPMMQGILEAGKALLGLVQDVIGDLHQCQRTWDKIFHNTLKIHLFSMAFR
ELQWLV----AKRVQDHTT-AVGDAVSPEMGESLFQLYISLKELYQLRPSSS-------E
RDGVLALDNFH--RW-FQPAIPSWLQKTYNVALARVQRAVQMDELVPLGELTKHSTSA-V
DLSTCFAQISHTARQLDWPDPEEAFMITVKFVEDTCRLALVYCSLIKARARELSSGQKDQ
GQAANM----LCVVVNDMEQLRLVIGKLPTQLAWEALEQRVGAVLEQGQLQNTLHAQLQS
ALAGLGH-EIRTGVRTLAEQLEVGIAKHIQKLVGVRESVLPEDAI-LPLMKFLEVELCYM
NTNLVQE---NFSSLLT--LLWTHTLTVLVEAA

PF10540 // ENSGT00730000110939_1_Domain_3 (1054, 1114)

ASQRSSSLASNRLKIALQNLEICFHAE
GCGLPPEALHTATFQALQRDLELQAASSRELIR

ENSGT00730000110939_1_Linker_3_4 (1114, 1146)

KYFCSRIQQQAETTSEELGAVTVKACY
RASEQ

PF00168 // ENSGT00730000110939_1_Domain_4 (1146, 1260)

KLRVELLSASSLLPLDSNGSSDPFVQLTLEPRHEFPELAARETQKHKKDLH----
---------PLFDETFEFLVPAEPCRKAGACLLLTVLDYDTLGADDLEGEAFLPLCEVPG
LSGSEE-----PGEVPQTRLPLTYPAPNG--------------------------DPILQ
LLEGRKGDREAQVFVRLRRHR--------AKQGIG--PSVSWPICLLAFLFQPL---GWG
P---GSLEPGLQVQSLLGKGGG-PCQR------------

------------------------------------------------------------
------------------------------------------------------------
--MATPLSHSQRRPPLLRQAIKI-----------------RR-----R-----R--V-RD
LQGPLPHTAQEIETPSHHFSPEERALLYEEALYTVLHRLGKPEPGHVSEASELLRYLQEA
FHVEPEEHQRML-----QQVQALEKPIFC

PF00168 // ENSGT00730000110939_1_Domain_0 (270, 380)

LKATVKQAKGILGKDVSGFSDPYCLLG-IEQ
GVGTLEGSPGS-RRRQKAVVKHTIPEEQTHRTQVITQTLNPVWDETFILEFEDIRNSSFH
LDMWDLDTVESVRQKLGEL

ENSGT00730000110939_1_Linker_0_1 (380, 643)

TDLHG----------LRR--IFKEARKDKGQDDFLGNVVLR
-------------LQDLRCREDQWYPLEPCTETYPDRGQCHLQFQLIHKRR-ATGASRSQ
PSYTVHLHLLQQLVSHEVTQHQAGSTSWDGLLSPQAATILFLHATQKDLSDFHQSMA-QW
LAYSRVYQSLEFPSSCLLHPITSIEYQWIQGRLKAEQMEELATSFSSLLAYGLSLIRRFR
SVFPLSVSDSPARLQSLLRVL--VQMCKMKAFRELCPDSGPL

PF06292 // ENSGT00730000110939_1_Domain_1 (643, 722)

PHLVTEALRAGTVEWF--
---HLKQQHHQPMVQGMLEAGKALLSLVQDIIGDLHQCQRTWNKIFHNALKIDLFAMAFL
ELQWLV----AKRVQDHTAAALRGLVSPEMGESLFQLYIILKELCQLGPAPS-------E
RDGVLALDGFH--RW-FQPAIPSWLQKTYSVALARVQRAVQMDKLVPLGELTKHSTSA-V
DLSTCFAQISHTARQLDWPDPEEAFMITVKFVEDTCRLALVYCSLIKARARELSAGQKDQ
GQAANM----LCVVVNDMEQLRLVIGRLPTQLAWEALEQRVGAVLEQGQLQNTLHAQLQG
ALAGLGH-EIRTGVRTLAEQLEVGIAKHIQNLVGVRESILPEDAI-LPLMKFLEVELCYM
NTNLVQE---NFSSLLT--LLWTHTLEVLVEGATSQRSCPLASSRLKIALQNLEICFYAE
GCGLQPEALHTATFQALQRDLELQAASSRELIQKYFCNRIQQQAETTSEELGAITVKASY
RASEQK

PF00168 // ENSGT00730000110939_1_Domain_4 (1147, 1252)

LHVEVLSASSLLPLDSNGSSDPFVQLTLEPRHEFPELAPRETQKHKKDLH----
---------PLFDETFEFLVPAEPCQKDGACLLLTVLDHDTLGADDLEGEAFLPLRSVLG
LSGTEE-----PGEVPQSRLPLTYPAPNG--------------------------DPILQ
LLESRKGDREAQVFVKLRRQRAKQASQH-----------------AVR----L-------
------GQ-------------------------------

------------------------------------------------------------
------------------------------------------------------------
---------------LLRQA----------------S-KIRR-----RRV--------KD
----------SIQPPSHHFSPEQRALLYEEALYTVLHRLVSLSPP-CDGGSELLRYLQEA
FHVEPEEHQQAL-----HRVRELEKPTFC

PF00168 // ENSGT00730000110939_1_Domain_0 (270, 447)

LKATVKQAKGILGKDVSGFSDPYCLLGI-EQ
GVGAPGGSPGS-RRRQKAVVKHTIPEEQTHRTQVVTQTLNPVWDETFILEFEDITNSSFH
LDMWDLDTVESVRQKLGELTDLHG----------LRR--IFKEARKDKGQDDFLGNVVLR
-------------LQDLRCREDQWYPLEPRTETYPDRGQCHLQFQLIHKRR-ATSASRSQ
PSYTVHLHLLQQLVSHEVTQHQAGSTSWDGSLSPQAATVLFLHATQKDLSDFHQSMA-QW
LAYSRLYQSLEFPSSCLLHPITSIEYQWIQGRLKAEQEEELAASFSSLLAYGLSLIRRFR
SVFPLSVSDSPARLQSLLRVL--VQMCKMKAFGELCPNTAPLPQLVTEALQTGTTEWF--
---HLKQQHHQPMMQGMLEAGKALLGLVQDIIGDLHQCQRTWDKIFHNTLKIHLFPMAFR
ELQWLV----AKRVQDHTT-AVGDAVSPEMGESLFQLYISLKELCQLRPSSS-------E
RDGVMALESFH--RW-FQPAIPSWLQKTYSVALARVQRAVQMDELVPLGELTKHSTSA-V
DLSTCFAQISHTARQLDWPDPEEAFMITVKFVEDTCRLALVYCSLIKARARELSSGQKDQ
AQAANM----LCVVVNDMEQLRLVIGKLPAQLAWEALEQRVGAVLEQGQLQNTLHAQLQS
ALAGLGH-EIRTGVHTLAEQLEVGIAKHIQKLVGVRESVLPEDAI-LPLMKFLEVELCYM
NTNLVQE---NFSSLLT--LLWTHTLTVL

PF10540 // ENSGT00730000110939_1_Domain_3 (1050, 1113)

EEVAASQRSSSLASNRLKIALQNLEICFHAE
GCGLPPEALHTATFQALQRDLELQAASSRELI

ENSGT00730000110939_1_Linker_3_4 (1113, 1146)

QRYFCGRIQQQAETISEELGAVTVKASY
RTSEQ

PF00168 // ENSGT00730000110939_1_Domain_4 (1146, 1260)

KLRVELLSASSLLPLDSNGSSDPFVQLTLEPRHEFPELAARETQKHKKDLH----
---------PLFDETFEFLVPAEPCRKPGACLLLTVLDYDTLGADDLEGEAFLPLCEVHG
LSGSEE-----PGEVPQTRLPLTYPVPNG--------------------------RPEPR
--EGWYKDREPVKLRQGPRRSNARLVGQPWPISWSNQKPRDRAIHLLAFLFQPL---GWG
PGSLGAGLQAQSLLG--KGQGTLPKMRLQLPWGEGGDHY

------------------------------------------------------------
------------------------------------------------------------
--MATRLSHPKRRPPLLRQAIKI-----------------RR-----R-----K--V-QD
LQDPPAQMTQEVSPASYHFSPKERDLLYEEALYTVLHRVGQPEPNHVVEASELMQYLQEV
SPAP--------------THRLLLKPVFC

PF00168 // ENSGT00730000110939_1_Domain_0 (270, 447)

LKATVKQAKGILGKDVSGFSDPYCLLGI-EQ
GVGVPGGSPGS-RRRQKAVVRHTIPEEQTHRTQVINQTLNPVWDETFILEFEDITNASFH
LDMWDMDTVESVRQKLGELTDLHG----------LRR--IFKEARKDKGQDDFLGNVVLR
-------------LQDLRCRDDQWYPLEPRTETYPDRGQCHLQFQLIHKRR-ATVASRSQ
PSYTVHLHLLQQLVSHEVTLHKVGSTSWDGSLSPQATTILFLHAVQKDLSDFHQSMA-QW
LAYSRLYQSLEFPSSCLLHPITSIEYQWIQGRLKAEQLEELTISFTSLLAYGLSLIRKFR
SVFPLSVSDSPARLQSLLRVL--VQMCKMKAFGELCQDTAPLPQLVTEALRTGTVEWF--
---HLKQQHHQPMVQDILEAGKALLSLVQDVLGDLHQCQRTWNKIFHNALKIDLFSTAFL
ELQWLV----AKRVQDHTS-AVGSPVSPEMGESLFQLYISLKELCQLGPAPLD------R
D-GVLALDGFH--HW-FQPAIPSWLQKTYSVALERVQRAVQMDKLVPLGELTKHSTSA-V
DLSTCFAQISHTAQQLDWPDPEEAFMITVKFVEDTCRLALVYCSLIKARARTLSAGQKDQ
GQAADM----LCVVVNDMEQLRLVIGKLPTQLAWEALEQRVGTVLDQGQLQNTLHTQLQS
ALAGLGH-EIRTGVQTLAEQLEVGIARHIQKLVDVKESVLPEDAI-LPLMKFLEVKLCYM
NTNLVQE---NFSSLLT--LLWTHTLTVLVE

PF10540 // ENSGT00730000110939_1_Domain_3 (1052, 1114)

VAASQRSSTLASGRLNVALQNLKICFHAE
GCGLPPEALHTATFQALQRDLELQAASSRELIR

ENSGT00730000110939_1_Linker_3_4 (1114, 1146)

KYFCSRIQQQAQTTSEQLGAVTVKASY
RSSEQ

PF00168 // ENSGT00730000110939_1_Domain_4 (1146, 1257)

KLHVELLSASSLLPLDSNGSSDPFVQLTLEPRHEFPELAPRETQKHKKDLH----
---------PLFDETFEFLVPAEPCRKEGACLLLTVLDHDTLGANDLEGEAFLPLCTVPG
LSGCEE-----PGEAPQTRLPLTYPMSNG--------------------------DPILQ
LLESRKGDREAQAFVRVRRQRAKQASQH---------------------ALRPGQ-----
---------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------MVFYEILQHQAGSTAWDGDLSKHASTILYLHAAQKDLSDFHQVMV-QW
LAYSKLYQSLEFNSSCLLHQITSIEYQWVQERLRPEQREELAESFQTLLAYGLSVLRKYR
IVFPLSSARSTHRLQSLLRVL--LQVCKMKAFQELCNLTPSLRQMVMDALKSGTTEWF--
---AMQKHHLKPIVKTMEEHGKALARLLVEVNGDLQQCHKIWNKFFINTVKVDLFSIAYM
ELQELV----SHHVKEELS-EIDSGMSHLTAENLFQLYLSLKELYRMRGFLS-------K
RDGPLALTDFH--QW-FKEAIPKWLQKTYTIALERTQRAIQVDKLTPLGELTKHSTST-V
DLSTCYAQIVKTWQQLDWPDPEEAFMIMVKFVEDMCKIALTYCKLIKTRAEELSRNQEDE
GDAANR----LCIVVNNVEQLRLLILKLPAQLDWGRMEQQLGGIVEPEQIQHTLHNQLQG
TVTCLDH-EIRDVVQTLANKLDAGISRHIQELAASSDSRDPEDSV-IPLMKFLELELQYM
NQHLVQE---NFNCLLD--LLWNHILSVLTAAAK

PF10540 // ENSGT00730000110939_1_Domain_3 (1055, 1115)

QQFSSSRYYRKLQFALQSLELCFHAE
GCGLPTNALHTAEFMDLEKELELRSAPSRTLIQQ

ENSGT00730000110939_1_Linker_3_4 (1115, 1147)

YFNERIREQLEIDSEKYGAVTIKALY
RPSEQK

PF00168 // ENSGT00730000110939_1_Domain_4 (1147, 1251)

LRIEVLNAVNLIPLDSNGSSDPFVQLTLEPRHMFPEVVARTTQCQKNELH----
---------PLFDEAFEFLVPPEKCQQDGACLLLTVFDYDTVGANDLEGEAFFPLCDVPG
LTGEEE--VADAGRVPQTRLPLMHPKPTG--------------------------DPILK
LLESRKGDKEAQAFVKLRKQRAKQSKESV-------------------------------
---------------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MATHFSHPQRRPPLLRQAIKI-----------------RR-----R-----R--A-KD
LQDPPPQTTQEVEPPSHHFSPEERNLLYEEALYTVLHRLGQPEPNHVKEASELLRYLREA
FQVQPAEHQQLL-----QHVRELEKPVFC

PF00168 // ENSGT00730000110939_1_Domain_0 (270, 447)

LKATVKQAKGILGKDVSGFSDPYCLLGI-EQ
GVGMPEGSPVS-RRRQKAVVRHTIPEEQTHRTQVISQTLNPVWDETFILEFEDITNASFH
LDMWDLDTVESVRQKLGELTDLHG----------LRR--IFKEARKDKGQDDFLGNVVLR
-------------LQDLHCREDQWYPLEPCTETYPDRGQCHLQFQFIHKRR-ATVASRSQ
PSYTVHLHLLQQLVSHEVTQHQAGNTSWDASLSPQATTILFLHATQKDLSDFHQSMA-QW
LAYSRLYQSLEFPSNCLLHPITSMEYQWIRGRLKAEQQEELASSFTSLLAYGLSLIRKFR
SVFPLSVSDSPARLQSLLRVL--VQMCKMKAFRELCPDNDPLPQLVSEALRAGTVEWF--
---HLKQQQHQSVVQGMLEAGKALLSLVQDVMGDLHQCRRTWNKIFHNVLKIDLFSMAFQ
ELQWLV----AKRVQGHTE-AVGSSMSPEMGESLFQLYVCLKEFCQLGPVPSD------R
WATVMALDGFH--LW-FQPAIPSWLQKTYSVALERVQRAVQMDSLVPLGELTKHSTSA-V
DLSTCFAQISHTARQLDWPDPEVAFMITVKFVEDTCRLALVYCSLIKARARELSKGQKDQ
SQAANM----LCVVVNDMEQLRLVIGKLPTQLAWEALEQRVGAVLEQGQLHNTLHAQLQG
ALAGLNH-EIRTGVRTLAEQLEVGIATRIQKLMGVKESVLPEDAI-VPLLKFLEVKLCYM
NTNLVQE---NFSRSAAPAPPWPHHPTSP------RPQRLLGAGARLQTPL

PF10540 // ENSGT00730000110939_1_Domain_3 (1072, 1114)

NLEICFHAE
GCGLPPEALHTATFKALQKDLELQAASSRELIQ

ENSGT00730000110939_1_Linker_3_4 (1114, 1146)

KYFRSRIQQQAETSSEQLGAVTIKASY
RASEQ

PF00168 // ENSGT00730000110939_1_Domain_4 (1146, 1257)

KLRVELLSASSLLPLDSNGSSDPFVQLTLEPRHEFPELAPRETQKHKKDLH----
---------PLFDETFEFLVPAEPCRKDGACLLLTVLDHDTLGADDLEGEAFLPLCRVPG
LTDCEE-----PGEVPQIRLPLTYPVLIG--------------------------DPILQ
LLESRKGDREAQAFVKLRRQRAKQAFQH---------------------TPRPRQ-----
---------------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MATARSHPQRRPPLFRQAIKIRRRRD------------------------------QD
IQALEPQTAQKVETTSHHFTPEERTLLYEEALYTVLHRLGQPEPSHVAEFSELVRYLQEA
FHLEPQEHQKML-----EQVLELEKPMFF

PF00168 // ENSGT00730000110939_1_Domain_0 (270, 343)

LKATVKQAKGILGKDVSGFSDPYCLLGI-EQ
GVGMSGGSPGS-RQRQKAVVRNTIPEEETHRTQVLMQTLNPV

ENSGT00730000110939_1_Linker_0_1 (343, 643)

WXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXX----------X--XXILKEVPKDKGQDDFLGNVVLR
-------------LQDLRCREDQWYPLEPRTETYPDRGHCHLQFQFIHKRR-ATRASRCQ
PSYTVHLHLLQQLVSHEVTRHQAGSISWDGLLSPQASTILFLHATQKDLSDFHQSMA-QW
LAYSRLYQSLEFPSSCLLHPITSIEYQWIQGRLKKEQLEELAASFSSLLAYGLSLIRRFR
SVFPLSVAHSPARLQSLLRVL--VQMCKMKAFGELCPDSPPL

PF06292 // ENSGT00730000110939_1_Domain_1 (643, 722)

PHLVTEALRTGTVEWF--
---HLKQQHHQPMVQGLLDAGKALLSLVQDVTGDLHQCQRTWDKIFHXXXXXXXXXXXXX
XXXXXX----XXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-------X
XDRVLALDGFH--RW-FQPAIPSWLQKTYNVALARVQRAVQMDQLVPLGELTKHSTSA-V
DLSTCFAQISHTARQLDWPTPEEAFMITVKFVEDTCRLALVYCSLVKARARELSAGQKDQ
GQAANM----LCVVVNNMEQLRLVISKLPAQLAWEVLEQRVAAVLEQGQLQHTLHAQLQS
ALAGLGH-EIRTGVRTLAEQLEVGIAKHIQKLLGIRESVLPEDAI-LPLMKFLEVELCYM
NTNLVQE---NFSSLLT--LLWTHTLTVLAEAAASQRNSLLASGRLKVALQNLEICFYAE
GCGLPPEALHTATFQALQKDLALQAASSQELIQKYFCSRLEQQAETTSEELGVVTVKASY
HASEQK

PF00168 // ENSGT00730000110939_1_Domain_4 (1147, 1252)

LRVELLSASSLLPLDSNGTSDPFVQLTLEPRHVFPELAPRETQKHKKDLH----
---------PLFDETFEFLVPAEPCQKEGACLLLTVLDHDTLGADDLEGEAFLPLHSVPG
LSGEEE-----PGKVPQTRLPLTYPTPNG--------------------------DPVLQ
LLESRKGDREAQAFVRIRRQRAKQAAQHSPRPGR--------------------------
---------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------CPPPSLLH-----PLTASQA
FHTEPEEHRQLL-----HQVQKLEKPVLC

PF00168 // ENSGT00730000110939_1_Domain_0 (270, 379)

LKATVKQAKGILGKDVSGFSDPYCLLGIEGR
GVPGSGDSPGPQRRRQKAVVRNTIPEDQTHRTQVINQTLCPVWDETFILEFEDVTSSSFH
LDMWDADEVESVRQKLGELTDLHG----------LRR--IFKEARKDKGQDDFLGNVVLR
LQVGA----DGA-----RSGAEGT------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MATHLSHPHRRPALLRQAVKI-----------------RR-----R-----R--V-RD
LQDPPPQTTQEVQVQSHHFSSEERDLLYEEALYTVLHRLGQPEPNHVKEASELLRYLQEA
FQVQPEEHQQML-----QRVGELEKPIFC

PF00168 // ENSGT00730000110939_1_Domain_0 (270, 447)

LKATVKQAKGILGKDVSGFSDPYCLLGIIEQ
GAGIAEGSPVS-RRRQKAVVKHTIPEEQTHRTQVKNQTLNPVWDETFVLEFEDITNASFH
LDMWDLDTVESVRQKLGELTDLHG----------LRR--IFKEARKDKGQDDFLGNVVLR
-------------LQDLRCRQDQWYPLEPCTETYPDRGQCHLQFQFIHKRR-ATVASRSQ
PSYTVHFHLLQQLVSHEVTQHQAGSASWDASLSPQGATILFLHATQKDLSDFHQSMA-QW
LGYSPPHQSLEFPSSCLLHPITSMEYQWIQGRLRAEQREELAASFTSLLTYGLSLIRKFR
SVFPLSVSDSPSRLQSLLRVL--VQMCKTKAFGELCPDSAPLSQLVSEALRTGTVEWF--
---HLMQQHHQPMVQGILEAGKALLSLVQDVMGDLYQCRHTWNKIFHNVLKIDLFSVAFL
ELQWLV----AKRVQDHTA-EAGKLVSPDMGEILFQLYVSLKEISQLGPGPSS------S
N-GVLALDGFH--RW-FQPAIPSWLQKTYSVALERVQRAVRMDSLVPLGELTKHSTSA-V
DLSTCFAQISHTARQLDWPDPEEAFMITVKFVEDTCRLALVYCSLIKARARELSTGQKDQ
GQAANM----LCVVVNNMEQLRLIIDKLPTQLAWEALEQRVGAVLEQGQLHNTLHAQLQG
TLAGLGH-EIRTGVRTLAEQLEVGIATHIQKLIGVKESVLPE

PF10540 // ENSGT00730000110939_1_Domain_2 (1003, 1051)

DAI-LPLMKFLEVKLRYM
NTNLVQE---NFSSLLT--LLWTHTLTVLVEVASSQRSSLLASSRLKAALQNLEICFHAE
GCGLPPEALHTATFQALQRDLELQSASSRELIQKYFCSRIQQQAETTSEQLGAVTIKASY
RASEQ

PF00168 // ENSGT00730000110939_1_Domain_4 (1146, 1257)

KLRVELLSASSLLPLDSNGSSDPFVQLTLEPRHEFPELAPRETQKHKKELH----
---------PLFDETFEFLVPAEPCQKDWACLLLTVLDHDTLGADDLEGEAFLPLCRVPG
LTGCEE-----PGEAPQTRLPLTYPAPNG--------------------------DPILQ
LLDSRKGDREAQAFVKLRRQRAKQASQH---------------------APR--------
---------------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MATHLSQSQRRPPLLRQAIKI-----------------RR-----R-----R--V-RD
LQDPLPRTAQEVGVT----SVRRRALLYEEALYTILHRLGQPEPNHVKEASELLRYLQEA
FHMGPEEHQQLL-----QKVQKLEKPIFC

PF00168 // ENSGT00730000110939_1_Domain_0 (270, 447)

LKATVKQAKGILGKDVSGFSDPYCLLG-IEQ
GVGAPGGSPGS-RHRQKAVVRHTIPEEQTHRTQVITQTLNPVWEETFILEFEDISNSSFH
LDMWDLDTVESVRQKLGELTDLHG----------LRR--IFKEARKDKGQDDFLGNVVLR
-------------LQDLRCQEDQWYPLEPCTETYPDRGQCHLQFQLIHKRR-ATAASRSQ
PSYTVHLHLLQQLVSHEVTQHQAGSTSWDGSLSPQAATILFLHATQKDLSDFHQSMA-QW
LAYSRLYQSLEFPSSCLLHPITSIEYQWIQGRLKAEQQEELAASFRNLLAYGLSLIRRFR
SVFPLSVPDSPARLQSLLRVL--VQMCKMKAFRELCPDSAPLPRLVTEALRTGTVEWF--
---HLKQQHHQPMVQGMLQAGKALLSLVQDIIGDLHQCQRTWNKIFQNALKVNLFSMAFL
ELQWLV----AKRVQDHTAAAAGSPVSPEVGESLFQLYVSLKELCQLGPVPHKRERRAEE
RDGVLALDGFH--RW-FQPAVPSWLQKTYSVALARVQRAVQMDELVPLGELTKHSTSA-V
DLSTCFAQISHTARQLDWPDPEEAFMITVKFVEDTCRLALVYCSLIKARARELSAGQKDQ
GQAANM----LCVVVNDMEQLRLVIGKLPTQLAWEALEQRVGAVLEQGQLQNTLYAQLQG
ALAGLGH-EIRTGVRTLAEQLEVGIAKHIQKLVSVKESVLPEDAI-LPLMKFLEVKLCYM
NTNLVQE---NFNSLLT--LLWTHTLTVLVE

PF10540 // ENSGT00730000110939_1_Domain_3 (1052, 1114)

VAASQRSCPLASSRLKIALQNLEICFYAE
GCGLPPEALHTATFQALQKDLELQAASSRELIQ

ENSGT00730000110939_1_Linker_3_4 (1114, 1146)

KYFCSRIQQQAEAASEELGAVTVKVSY
RASEQ

PF00168 // ENSGT00730000110939_1_Domain_4 (1146, 1260)

KLRVELLSASSLLPLDSNGSSDPFVQLTLEPRHEFPELAPRETQKHKKDLH----
---------PLFDETFEFLVPAEPCRKDGACLLLTVLDHDTLGADDLEGEAFLPLRSVPG
LTGTEE-----PGEVPQTRLPLTYPALNG--------------------------DPILQ
LLESRKGDREAQVFVRLRRQRAKQASQH-----------------APK----P-------
------GR-------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MATLLSHLQQRPPLLRQA----------------I-KIRR-----RRV--------RD
LQDPLPQTAPEIQPPSHHFSPEQRALLYEDALYTVLHRLGQPEPSHVTEASELLQYLQEA
FHVEPEEHQQV-L----QRVRELEKPIFC

PF00168 // ENSGT00730000110939_1_Domain_0 (270, 447)

LKATVKQAKGILGKDVSGFSDPYCLLGI-EQ
GVSVPGGSPGS-RHRQKAVVRHTIPEEQTHRTQVITQTLNPVWDETFILEFEDITNASFH
LDMWDLDTVESVRQKLGELTDLHG----------LRR--IFKEARKDKGQDDFLGNVVLR
-------------LQDLHCREDQWYPLEPRTETYPDRGQCHLQFQLIHKRR-ATSASRSQ
PSYTVHLHLLQQLVSHEVTQHQAGSTSWDGSLSPQAATVLFLHATQKDLSDFHQSMA-QW
LAYSRLYQSLEFPSSCLLHPITSIEYQWIQGRLKAEQQEELAASFSSLLAYGLSLIRRFR
SVFPLSVSDSPARLQSLLRVL--VQMCKMKAFGELCPNTAPLPQLVTEALQTGTTEWF--
---HLKQQHHQPMMQGILEAGKALLGLVQDVISDLHQCQRTWDKIFHNTLKIHLFSMAFR
ELQWLV----AKRVQDHTT-AVGDAVSPEMGESLFQLYISLKELCQLRPSSS-------E
RDGVLALDNFH--RW-FQPAIPSWLQKTYNVALARVQRAVQMDELVPLGELTKHSTSA-V
DLSTCFAQISHTARQLDWPDPEEAFMITVKFVEDTCRLALVYCSLIKARARELSSGQKDQ
GQAANM----LCVVVNDMEQLRLVIGKLPTQLAWEALEQRVGAVLEQGQLQNTLHAQLQS
ALAGLGH-EIRTGVRTLAEQLEVGIAKHIQKLVGVRESVLPEDAI-LPLMKFLEVELCYM
NTNLVQE---NFSSLLT--LLWTHTLTVLVEAA

PF10540 // ENSGT00730000110939_1_Domain_3 (1054, 1114)

ASQRSSSLASNRLKIALQNLEICFHAE
GCGLPPEALHTATFQALQRDLELQAASSRELIR

ENSGT00730000110939_1_Linker_3_4 (1114, 1146)

KYFCSRIQQQAETTSEELGAVTVKACY
RASEQ

PF00168 // ENSGT00730000110939_1_Domain_4 (1146, 1260)

KLRVELLSASSLLPLDSNGSSDPFVQLTLEPRHEFPELAARETQKHKKDLH----
---------PLFDETFEFLVPAEPCRKAGACLLLTVLDYDTLGADDLEGEAFLPLCEVPG
LSGSEE-----PGEVPQTRLPLTYPAPNG--------------------------DPILQ
LLEGRKGDREAQFFVRLRRHR--------AKQGIG--PSVSWPICLLAFLFQPL---GWG
P---GSLEPGLQVQSLLGKGGG-PCQR------------

------------------------------------------------------------
------------------------------------------------------------
--MATHLSHPQRRPPLLRQAIKI-----------------RR-----R-----R--V-RD
LQDPAPQTTQEVGVTTE--GKEPRDQLYEEALYTVLHRLGQPAPNHVKETSELLRYLQEA
FQVQPEEHQQML-----QRVGELEKPVFC

PF00168 // ENSGT00730000110939_1_Domain_0 (270, 447)

LKATVKQAKGILGKDVSGFSDPYCLLGI-EQ
GVGVPEDSPVS-RHRQKAVVRHTIPEEQTHRTQVKSQTLNPVWDETFILYV---------
--ALDLDTVESVRQKLGELTDLHG----------LRR--IFKEARKDKGQDDFLGNVVLK
-------------LQDLRCREDQWYPLEPCTETYPDRGRCHLQFQFIHKRR-ATVASRSQ
PSYTVHLHLLQQLVSHEVTQHQAGSTSWDASLSPQGATILFLHATQKDLSDFHQSMA-QW
LAYSRLYQSLEFPSSCLLHPITSIEYQWIQGRLKEEQREELATSFTSLLAYGLSLIRKFR
SVFPLSVSDSPSRLQSLLRVL--VQMCKTKAFGELCPDSVPLPQLVAEALRMGTVEWF--
---HLMQQHHQPMVQGILEAGKALLSLVHDVMDDLYQCRHTWNKIFHNVLKIDLFSVAFQ
ELQWLV----AKRVQDHTA-AVGSLVSPDMGESLFQLYVTLKELCQLGPVPSD------S
--GVLALDGFH--RW-FQPAIPSWLQKTYSVALERVQRAVQMDPLVPLGELTKHSTSA-V
DLSTCFAQISHTARQLDWPDPEEAFMITVKFVEDTCRLALVYCSLIKARARELSAGQKDQ
GQAANM----LCVVVNNMEQLRLVIHKLPTQLAWEALEQRVGAVLEQGQLQNTLHAQLQG
ALAGLGH-EIRTGVRTLAEQLEVGIATHIQKLIGAKESVLPEDAI-LPLMKFLEVKLCYM
NTNLVQE---NFNSLLT--LLWTHTLTVLV

PF10540 // ENSGT00730000110939_1_Domain_3 (1051, 1114)

EVASSQRSSSLASSRLKAALQNLEICFHAE
GCGLPPEALHTATFQTLQRDLELQAASSRELIQ

ENSGT00730000110939_1_Linker_3_4 (1114, 1146)

KYFCSRIQQQAETTSERLGAVTIKASY
RASEQ

PF00168 // ENSGT00730000110939_1_Domain_4 (1146, 1257)

KLHVELLSASSLLPLDSNGSSDPFVQLTLEPRHEFPELAPRETQKHKKELH----
---------PLFDETFEFLVPAEPCQKAWACLLLTVLDHDTLGADDLEGEAFLPLCRVPG
LTGCED-----PGEAPQTRLPLTYPAPNG--------------------------DPILQ
LLESRKSDREAQAFVKLRRQRAKQASQH---------------------ASHPGR-----
---------------------------------------

------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------MDPAAESP
PG-TLPGEESPEMDLSHRLSREELALLYEEVLYTILHRLGKPEPQHVGDCRELYCYVQKA
FGMDPEEHSAIM-----QQVMELESPIYC

PF00168 // ENSGT00730000110939_1_Domain_0 (270, 379)

LKATVKEAKGILGKDVSGLSDPYCLLGIEAR
SQEP---AHPEHKKRMKAVVKDLIPEDQIHRTQVMNQTLSPVWNETFILEFKDVETASFH
LDMWDSDVVESMRHKLGELTDLHG----------LKR--IFKDARKDKGQDDFLGNVVVR
-------------LKDLHCWNDQWYQLEPRTETYPERGHCHLQFLLTHKKR-ATTSSRTQ
PSYTVHRHLLQQLVSHEILQHQAGSTSWDGELSSHASTVLYLHATQKDLSDFHQDMA-QW
LAYSKLYQSLEFNSSCLLHQITSIEYRWVQERLRPEQKAELAESFQSLLTYGVSLIRRFR
IIFPLSVPRSKDRLQSLLRVL--VQMCKTKAFHELCTPSPDLPQMVSTALKSGTAEWF--
---HMQKQHLKPMVKSIEENSKALSKLLLEVIEDLKQCQKIWNKLFIINLKLNIFSIAYL
ELESLV----AEHVQEQLH-RVDSSMSKPTAESLFDLYRKLQELWEMKEFLP-------S
RDGPLALSNFH--QW-FEEALPLWLQKAYSTTLERAHRAIQMDQLKPYGYH-KHSTST-V
DLSTCYAQIVTTWQQLNWPDPEKAFMIMVNLLEDMCKISLMYCKLIKERAEALSLSEQNE
GEAANK----LCIVVNNIKQLRLLMLKLPEQLDWNQLEQRTRGIIDPQQIQNALHNQLDS
TVACLDH-EVRDVVQALATKMEKGIARHIQELSSCSDTQKP

PF10540 // ENSGT00730000110939_1_Domain_2 (1002, 1051)

EDSI-IPLMKFLESELQYL
NEHLVQE---NFKSLLT--LLWHHTLSVLSAARGPQVPSVQHCQRLFCALKSLERCFHAE
GCGLPLETINSAAFQTLETHLALCSAPSRKLIQKYFSNRIQQQLDTSSEKYGAVTIKALY
RPSEQK

PF00168 // ENSGT00730000110939_1_Domain_4 (1147, 1251)

LRVEVLNATNLIPLDSNGSSDPFVQLTLEPRHEFPEVVARTTQCKKNELH----
---------PLFDEAFDFLIPAEKCRQEGACLLLTVFDYDVLGANDLEGEAFLPLCRLPG
LEPEQD--GAEPGRVPQTRLPLTHPKPTGTCGLSRAAQGTGAGGAFPPWLPSSLADEILR
LLESRKGDKEAQAFVKLRKQRAKQSKETE-------------------------------
---------------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MATHLSQPHRRPPLLRQAIKI-----------------RR-----RRV--------RD
LQDPPPQTTQEVQVQAHHFSSEERDLLYEEALYTVLHRLGQPEPNHVKDASELLRYLQEA
FQVQPEEHQQML-----QRVGELEKPIFC

PF00168 // ENSGT00730000110939_1_Domain_0 (270, 351)

LKATVKQAKGILGKDVSGLSDPYCLLGIIEQ
GAGIPEGSPVS-RRRQKAVVKHTIPEEQIHRTQVKNQTLNPVWDETFVLYVGRP------
---WLYPLFPAPTGSFGCR-----------------------------------------
----------------FPSQGDQWSS----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------