Query Results 

---------------------------------------MGLWLLFPLLLLWPRGTRGSQ
-----LDPSGQHVCVASSPSAELQCCTGWRQKDQECSIP-ICEGPDACREDEVCVKPGLC
RCKPG-FFGAHCSSR--CPGQYWGPDCRES

PF00053 // ENSGT00730000110380_4_Domain_2 (151, 178)

CPCHPHGQCEPATGTCRCQADRWGARCEFP
CACG-PHGRCDFATGV-CRCEPGWWSSTCRRP

PF00053 // ENSGT00730000110380_4_Domain_4 (213, 260)

CQCNPV----------AAHCEQATGACV
CQ---------PGWWG-RRCTFRCACHGSPCEQDSGRCACRLGWWGPDCRQQCQCERGQC
NPASGQCTCPPGFRGARCELP----CPAGSYGVQCGLSCGHCKHDEPCSPDTGSCESCQP
GWNGTQCQQPCPPGTFGKSCGQQCPHCQHGEACQPDTGHCQHCDP--GWLR---------
------------------------------------PRCVDPCPTGTFGEDCGSTCPTCV
QGACDAVTGECVCSAGYWGPSCNASCSAGFYGNNCSVPCECPEGLCHPVSGSCQPG--FR
GR-ATALLMGILVPLLLLFLGLACCAC-CCWTAHSDLKDRPA-RDGTTVSRMKLQ-VWGT
LT-SLRSSLPCGSLSAHKLPWVT---VSHHDPDLPFNHSFIEPPSAGWASDDSFSSDSES
-AEADEAPAYCVPPQEG-M-VPVAQAQLSEASL-AGGAFP-----P-EDASTPFAIPRTS
SLARAKRPSVSFAEGTKFASQTRRSSGELSSPLRKPKRLSRGAQAAPE-GQ--EAEESTG
PEEA----EAGE---SLPMAAS--PGDSATGHRRPPLGGLTVAEHVEAIE--------GG
VQEASGPVTTIYVLAGTPRE-----------PGSPIRSVLRHFGGFQKGQAE----P---
KVKRAIPKPPRQALNRKKGS-----------------------------PGVAC--VTQS
PSSA-PNARLPGAMGS--PAARPE-----EV---AQGLGAGT---ESSGGTQEPVSGGGS
PEQDPQKQAE---EERQEEPEYENVMPIPRLPEP--------

-----------------------------------MLAAMGLELVFSLLLLWTQGTQGST
-----LDPAGQHVCKGSSPS-ELQCCPGWRQKDQECTIP-ICEGPDACRKEEVCVKPGL

PF12661 // ENSGT00730000110380_4_Domain_1 (120, 132)

C
RCKPG-FFGAQ

ENSGT00730000110380_4_Linker_1_2 (132, 151)

CSSR--CPGQYWGHDCRET

PF00053 // ENSGT00730000110380_4_Domain_2 (151, 178)

CPCHPRGQCEPATGDCQCQPNYWGRLCEFP
CTCG-PHGQCDPKTGL-CHCDPGWWSPTCRRP

PF00053 // ENSGT00730000110380_4_Domain_4 (213, 261)

CQCNP-----------AARCDQATGTCV
CP---------PGWWG-RRC

ENSGT00730000110380_4_Linker_4_5 (261, 307)

SFSCNCHTSPCMQDSGRCVCLPGWWGPECSRKCQCVRGQC
SVTSGH

PF12661 // ENSGT00730000110380_4_Domain_5 (307, 318)

CSCPPGFHGIRCELP----CNPGHYGAQCKESCGHCELNATCSPVTGNCESCKP
GWNGTQCKQPCPAGTFGERCTGQCPRCRLGEPCQKETGHCQRCDP--GWLG---------
------------------------------------HRCENPCPLGTFGKGCSSTCPACA
QGTCDAVTGECVCSAGYWGTSCNSSCPAGFHGNNCSMPCQCPEGLCHPVSGTCQLG--RH
G--KNALIVGILVPLLLLLMGIVCCAY-CCSGTRLDPKDRPE-RNGAAFFRMKQQ-VWGA
LT-NLGSALPCGSLSNYKLPWVT---VSHHDPEVPFNHSFIEPPSAGWASDDSFSSDPDS
-GEEDEAHAYFVPPREE-T-VPMAQEESPEASL-PGGSFP-----PPEDASTPFPIPRTS
SLARAKRPSVSFAEGTKFAPQNGRSSGDLSSPIRKPKRLSRGAQPRPE-GQ--EAEESTG
PEQV----NTEE---DAPMASS--SGDPATSHGQLPPGSQMVAECAETTD--------GG
IQESSGSVATIYMLAGTPQK-----------PEGPVWSVFRRLGNYQKDQMA----P---
KVKSAIPKPLRRSLGRNQASA--GSA----------------------------------
-----PGAVLSQ--AMESTAVRPE-----ET---PRGLGDGI---ESSGTVQEPDAGGSS
LEQDSQKQAN---EKEQEEPLYENVVPMSVPPQH--------

-----------------------------------MLAAMGLELVFSLLLLWTQGTQGST
-----LDPAGQHVCKGSSPS-ELQCCPGWRQKDQECTIP-ICEGPDACRKEEVCVKPGLC
RCKPG-FFGAQCSSR--CPGQYWGHDCRET

PF00053 // ENSGT00730000110380_4_Domain_2 (151, 178)

CPCHPRGQCEPATGDCQCQPNYWGRLCEFP
CTCG-PHGQCDPKTGL-CHCDPGWWSPTCRRP

PF00053 // ENSGT00730000110380_4_Domain_4 (213, 261)

CQCNP-----------ASRCDQATGTCV
CP---------PGWWG-RRCSFSCNCHTSPCMQDSGRCVCLPGWWGPECSRKCQCVRGQC
SVTSGHCSCPPGFHGIRCELP----CNPGHYGAQCKESCGHCELNATCSPVTGNCESCKP
GWNGTQCKQPCPAGTFGERCTGQCPRCRLGEPCQAETGHCQHCDP--GWLG---------
------------------------------------HRCENPCPLGTFGKGCSSTCPACA
QGTCDAVTGECVCSAGYWGTSCNSSCPAGFHGNNCSMPCQCPEGLCHPVSGTCQLG--RH
G--KNALIVGILVPLLLLLMGIVCCAY-CCSGTRLDPKDRPE-RNGAAFFRMKQQ-VWGA
LT-NLGSALPCGSLSNYKLPWVT---VSHHDPEVPFNHSFIEPPSAGWASDDSFSSDPDS
-GEEDEAHAYFVPPREE-M-VPMAQEESPEASL-PGGSFP-----PPEDASTPFPIPRTS
SLARAKRPSVSFAEGTKFAPQNGRSSGDLSSPIRKPKRLSRGAQPRPE-GQ--EAEESTG
PEQV----NTEE---DAPTATS--SGDPATSHGQLPPGSQMVAECAETTD--------GG
IQESSGSVATIYMLAGTPQK-----------PEGPVWSVFRRLGNYQKDQMD----P---
KVKSAIPKPLRRSLGRNQASA--GSA----------------------------------
-----PGAVLSQ--AMESTAVRPE-----ET---PRGLGDGI---ESSGTVQEPDAGGSS
LEQDSQKQAE---EKEQEEPLYENVVPMSVPPQH--------

---------------------------------------MGLGLLLPLLLLWTRGTQGSE
-----LDPKGQHVCVASSPSAELQCCAGWRQKDQECTIP-ICEGPDACQKDEVCVKPGLC
RCKPG-FFGAHCSSR--CPGQYWGPDCRES

PF00053 // ENSGT00730000110380_4_Domain_2 (151, 178)

CPCHPHGQCEPATGACQCQADRWGARCEFP
CACG-PHGRCDPATGV-CHCEPGWWSSTCRRP

PF00053 // ENSGT00730000110380_4_Domain_4 (213, 261)

CQCNTA----------AARCEQATGACV
CK---------PGWWG-RRCSFRCNCHGSPCEQDSGRCACRPGWWGPECQQQCECVRGRC
SAASGECTCPPGFRGARCELP----CPAGSHGVQCAHSCGRCKHNEPCSPDTGSCESCEP
GWNGTQCQQPCLPGTFGESCEQQCPHCRHGEACEPDTGHCQRCDP--GWLG---------
------------------------------------PRCEDPCPTGTFGEDCGSTCPTCV
QGSCDTVTGDCVCSAGYWGPSCNASCPAGFHGNNCSVPCECPEGLCHPVSGSCQPG--SG
SR-DTALIAGSLVPLLLLFLGLACCAC-CCWAPRSDLKDRPA-RDGATVSRMKLQ-VWGT
LT-SLGSTLPCRSLSSHKLPWVT---VSHHDPEVPFNHSFIEPPSAGWATDDSFSSDPES
-GEADEVPAYCVPPQEG-M-VPVAQAGSSEASL-AAGAFP-----PPEDASTPFAIPRTS
SLARAKRPSVSFAEGTKFAPQSRRSSGELSSPLRKPKRLSRGAQSGPE-GR--EAEESTG
PEEA----EAPE---SFPAAAS--PGDSATGHRRPPLGGRTVAEHVEAIE--------GS
VQESSGPVTTIYMLAGKPRG-----------SEGPVRSVFRHFGSFQKGQAE----A---
KVKRAIPKPPRQALNRKKGS-----------------------------PGLASGSVGQS
PNSA-PKAGLPGATGP--MAVRPE-----EA---VRGLGAGT---ESSRRAQEPVSGCGS
PEQDPQKQAE---EERQEEPEYENVVPISRPPEP--------

---------------------------------------MGLELLLPLLLLWTQKTQESE
LDPEGLDPEGQNVCKSSSPLAELLCCPGWRQKDQECTIP-ICEGPDACRKDEVCVKPGLC
RCKPG-FFGAQCSSP--CPDQYWGPDCREI

PF00053 // ENSGT00730000110380_4_Domain_2 (151, 178)

CSCHPHGKCDPVTGVCRCQADRWGSNCEFQ
CSCG-THGRCDPKTGL-CHCDPGWWSDTCRRR

PF00053 // ENSGT00730000110380_4_Domain_4 (213, 261)

CRCNP-----------LAQCDATTGTCL
CP---------SGWWG-ERC

ENSGT00730000110380_4_Linker_4_5 (261, 298)

NFRCSCHKSPCTPDTGRCKCLPGWWGTDCRQPCSCIY

PF00053 // ENSGT00730000110380_4_Domain_5 (298, 335)

GSC
HGTSGQCICKLGFQGTNCD----LPCTPGYYGLHCFQRCGHCKQSAPCSKDLGFCESCEP
GWNGTLCQVPCSPGTFGETCSQQCPHCRGGEPCQVETGHCEHCDP--GRMGP--------
-------------------------------------RCEDSCPVGTFGEDCSSICPTCV
QGACDPQTGECVCSAGYWGTSCNSSCLPGFYGNNCSLPCQCSDGLCSPVSGACHWG--HL
SK-EVALIAGSLVLLLLLLLGIAC----YCWATRLDPKDRPS-RGGTTLSRMKQR-VCGA
LS-SLGSALLCGSLSGYKLPWVT---VSHHDPEVPFNHSFIEQPSAGWASEDSFSSDSES
-GAENEDSAYCVSSPKG-T-VPVA-----QAES-LEATFP-----PPEDASTPFPIPRTS
SLARAKRPSVSFAEGTKFVSQSCRSSGELSSPIRKPKRLSRGAQAGPE-SQ--ETEESTS
MEQA----QVDK---APPAA--ARPSNSAN-GHRFPLDNQRVAEHGETTK--------DN
VQKSSDSVATIYMLAGMPER-----------SEGPVWSVFRRLGNFQKGQAE----A---
KVKSAIPKPPRRALAQKGST------------------------------TPSPGSANQS
PG---LAPSLVGAAES--RGVRQE-----EV---SRVLGDGS---ENPGGTWEPVSRNSL
PEHAPQKQAE---EEGAEEPLYENVRVPG-------------

-----------------------------------MLAAMGLELVFSLLLLWTWGTQGST
-----LDPTGQHVCKGSSPS-ELQCCPGWRQKDQECTIP-ICEGPDACRKDEVCVKPGLC
RCKPG-FFGAQCSSR--CPGQYWGHDCRET

PF00053 // ENSGT00730000110380_4_Domain_2 (151, 178)

CPCHPRGQCEPATGVCQCHPNYWGGLCEFP
CTCG-PHGQCDPKTGL-CHCDPGWWSPTCRRP

PF00053 // ENSGT00730000110380_4_Domain_4 (213, 261)

CQCNP-----------AARCDQATGACV
CP---------PGWWG-RRCSFSCNCHTSPCMQDSGRCICLPGWWGPECSRRCQCVRGQC
SVTSGHCSCPPGFHGIRCELS----CNPGHYGAQCKESCGHCEPNATCSPVTGNCESCKP
GWNGTQCKQPCPAGTFGERCTGQCPRCRLGEPCQAETGHCQRCDP--GWLG---------
------------------------------------HRCENPCPLGTFGKGCSSTCPACV
QGTCDAVTGECVCSAGYWGTSCNSSCPSGFHGSNCSIPCQCPEGLCHPVSGACQLG--RH
G--KNALIVGILVPLLLLLMGIVCCAY-CCSGTRLDPKDRPE-RNGAALFRMKQQ-VWGA
LT-NLGSALPCGSLSNYKLPWVT---VSHHDPEVPFNHSFIEPPSAGWASDDSFSSDPDS
-GEEDEAHAYFVPPREE-T-VPMAQEESPEASL-PGGSFP-----SPEDASTPFPIPRTS
SLARAKRPSVSFAEGTKFAPQNGRSSGDLSSPIRKPKRLSRGAQPRPE-GQ--EAEESTG
PEQA----NTEE---DAPTATS--SGDAAASHGQLPPGSRMVAECVETSD--------GG
IQESSGSVATIYMLAGTPQK-----------PEGPVWSVFRRLGNYQKDQAA----P---
KVKSAIPKPLRRSLGRNQASA--GSA----------------------------------
-----PGTVLSG--AMESTAVRPE-----ET---PRGLGDGI---ESSGTVQEPDAGGSS
LDQGSQKQAE---EKEQEEPLYENVVPLSGPPQH--------

-----------------------------------PLAAMGLGLVFPLLLLWTRETQGST
-----LDPAGQHVCRGSSPS-ELQCCPGWRQKDEECTIP-ICEGPDACKKDEVCVKPGLC
RCKPG-FFGAQCSSR--CPGQYWGPDCRET

PF00053 // ENSGT00730000110380_4_Domain_2 (151, 178)

CPCHPRGQCESATGVCRCQPNYWGRLCEFT
CTCG-PHGQCDQKTGL-CHCDPGWWSPTCRRP

PF00053 // ENSGT00730000110380_4_Domain_4 (213, 261)

CQCNP-----------AARCDQTTGACL
CP---------SGWWG-RRCSFKCSCHNSPCVQDSGHCTCLPGWWGPECNHRCQCVRGQC
SVTSGHCSCPPGFYGARCELP----CNPGHYGVQCRESCGHCQLNATCSPVTGTCESCKP
GWNGTQCKQPCPLGTFGERCREQCPRCRLGEPCHAETGHCQRCDP--GWLG---------
------------------------------------HRCENSCPLGSFGEGCSSICPTCV

PF00053 // ENSGT00730000110380_4_Domain_7 (481, 521)

QGTCDAVTGECVCSAGYWGTSCNNSCPPGFYGNNCSTPCQCSEGLCHPVSGACQLG--QH
G--KNALIVGILVPLLLLLVGLICCVY-CCSATRLDPKDRPE-RNGAALFRMKQQ-VWGA
LT-SLGSSLPCGSLSNYKLPWVT---VSHHDPEIPFNHSFIEPPSAGWASDDSFSSDPDS
-GEEDENHTYSVPPREG-M-VSVTQEESPAASL-PGGPFP-----PPEDASTPFPIPRTS
SLARAKRPSVSFAEGTKFAPQNGRNSGDLSSPIRKPKRLSRGAQPRPE-GQ--EAEEPAG
PEQA----NTEE---DTPTATS--PGDAATS-HQLPPTNQTVAECVETTN--------GS
IQESSGSVATIYMLAGTPQK-----------PEGPVLSVFRRLGNYQKDQAV----P---
KVKSAIPKPLRRSLGRNQGSS--GSA----------------------------------
-----PEAMLSG--TVESTEVRPE-----EA---SRGMGDGI---ESLTTVQEPVSGNSS
LEQCSQKQAE---EKEQEEPLYENYVPMSVLPQH--------

---------------------------------------MGLGLLLPLLLLWTQGTQGSE
-----LDPNGQHVCVASSPSAELQCCAGWRQKDQECTIP-ICEGPDACQKDEVCVKPGLC
RCKPG-FFGAHCSSR--CPGQYWGPDCRES

PF00053 // ENSGT00730000110380_4_Domain_2 (151, 178)

CPCHPHGQCEPATGACQCQADRWGARCEFP
CACG-PHGRCDPATGV-CHCEPGWWSSTCRRP

PF00053 // ENSGT00730000110380_4_Domain_4 (213, 261)

CQCNPA----------AARCEQATGACV
CK---------PGWWG-RRCSFRCACHGSPCEQDSGRCACRPGWWGPECRQQCECVRGRC
SAASGECTCPPGFRGARCELP----CPAGSHGVQCAHSCGHCKHNEPCSPDTGSCESCEP
GWNGTQCQQPCLPGTFGESCEQQCLHCQHGEACEPDTGHCQRCDP--GWLG---------
------------------------------------PRCEDLCPTGTFGEDCGSTCPTCV
QGACDAVTGECVCSAGYWGPRPE--CPP----------------------SLAPPG--SH
RR-DAALIAGSLVPLLLLFLGLICCAC-CCWATRSDLKDRPA-RDGATVSRMKLQ-VWGT
LT-SLGSTLPCGSLSSHKLPWVT---VSHHDPEVPFNHSFIEPPSAGWASDDSFSSDPES
-GEADEGPAYCVPPQEG-M-VPVAQAESSEASL-AAGAFP-----PPEDASTPFAIPRTS
SLARAKRPSVSFAEGTKFAPQSRRSSGELSSPLRKPKRLSRGAQSGPE-GR--EAEESTG
PEEA----EAHE---SFPAAAS--PGDSATGHRRPPLGGRTVAEHVEAIE--------GS
VQESSGPVTTIYMLAGTPQG-----------PEGPVRSVFRHFGSFQKGQAE----P---
KVKRAIPKPPRQ------GS-----------------------------PGLASGSVSQS
PNSA-PKAGLPGATGP--VAVRPE-----EA---AQGLGAGM---ESSGRAQKPISGGGS
PKRDPQKQAK---EERQEEPEYENVVRIS-------------

---------------------------------------MGLGLLLPLLLLWTRGTQGSE
-----LDPNGQHVCVASSPSAELQCCAGWRQKDDECTIP-ICEGPDACQKDEVCVKPGLC
RCKPG-FFGAYCSSR--CPGQYWGPDCRES

PF00053 // ENSGT00730000110380_4_Domain_2 (151, 178)

CPCHPHGQCEPATGACQCQADRWGARCEFP
CACG-PHGRCDPATGV-CRCQPGWWSPTCRRP

PF00053 // ENSGT00730000110380_4_Domain_4 (213, 261)

CQCNPE----------AARCEQATGACV
CK---------PGWWG-RRCSFRCTCHGSPCEQDSGRCACRPGWWG--------------
--------------------------------------CGHCKHNEPCSPDTGSCESCEP
GWNGTQCQQPCLPGTFGESCGQQCSHCRHGEACQPDTGHCQRCDP--GWLG---------
------------------------------------PRCEDPCPTGTFGEDCGSTCPTCV
QGACDAVTGECVCSAGYWGPSCNASCPAGFHGHNCSVPCECPEGPCHPVSGSCQPG--SR
SR-DATLIASSLVPLLLLFLGLACCAC-CCWATRSDLKDRPA-RDRATVSRMKMQ-VWGT
LT-SLGSTLPCGSLSSHKLPWVT---VSHHDPEVPFNHSFIEPPSAGWASDDSFSSDPES
-VEADEVPAYCVPPHEG-M-VPVAQAESSEASL-AAGAFP-----PPEDASTPFAIPRTS
SLARAKRPSVSFAEGTKFAPQSRRGSGELSSPLRKPKRLSRGAQLGPE-GR--EAEESTG
LEEA----ETDE---SLPAAAS--PGDSATGPRRPPLGGRTVAEHVEAIE--------GS
VQESSGPVTTVYMLVGTPQG-----------SEGPVRSAFRHFGGFQKGQAE----P---
KVKRAIPKPPRQALNRKKGS-----------------------------RGLASGSVSQS
PNSA-PKAGLPGVTGP--MAVRPE-----EV---ARGLGAGT---ENSGRAQEPISGAGF
PKQDPQKQAE---EERQEEPEYENVVPISRPPEP--------

---------------------------------------MGPW---PLLLLWVWGVLGEL
----ELDPVGRHVCLDGSSPVKSVCCPGWRQEGRECTVP-I

PF07974 // ENSGT00730000110380_4_Domain_0 (102, 132)

CEGPDACGKEEVCVKPGLC
RCKPG-FFGAQCSSX--XXXXXXXXXXXXXXPCYPNGKCDAVTGQCTCNMDHWGGNCQFL
CPCG-LHGHCNPLTGA-CRCKPGWWTPTCRKA

PF00053 // ENSGT00730000110380_4_Domain_4 (213, 260)

CQCS----SS------SLGCDQMTGACQ
CE---------PGWWG-RRCSFRCSCHHSACDQNTGRCICRAGWWGSECQKPCTCQHGHC
NPTNGHCTCHPGYQGLSCEHT----CPPGHYGVQCLNSCGYCRQSQPCSPDTGSCLACEP
GWNGTHCNQPCSSGTYGENCGQLCPQ

PF00053 // ENSGT00730000110380_4_Domain_6 (387, 476)

CRQGEACQPETGHCQHCDP--GRTG---------
------------------------------------PRCEEPCAPGTFGEACGSLCPPCV
EGICDAVTGDCVCRSGYWGPSCNASCPLGFYGVNCSSPCPCPEGPCHHASGACELX--XX
X--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXPT-RDGTAVSRVKMQ-VRGA
LS-SLGSALPCSSLSNHKLPRVT---VSHHDPEIPFNHSFIEPPSAGWASDDSFSSDPDS
-GEEDEGPAYCVPPQQV---ISFTEEELQDAHQ-AGKPVS-----APDDTSTPFVIPRTS
SLARAKRPSVSFAEGTKFGPQNSQESGELASPTRKPKRLSRPGQPQAE-GQ--EAEGSPG
LERP----EDPQPDFQEPPSTTAAQQDLSSGHRKLPLGGRTVAQRVEAIE--------NG
NRRSPGPVTTIYMLAGTPRG-----------AEGPVRAVLRRFGSFQKGRVE----P---
KAKGSIPKPPRRALSRDKGTLIPSPARS-----------------------L------DS
PV-----PGLS--ETAALSESSQE-----EE---TGRLGNTTGGAG-----M----ISC-
VEDT-----GQLTEEVDNEPQYENVKPGSGTLNS--------

---------------------------------------MGLGLLLPLLLLWTRGTQGSE
-----LDPKGQHVCVASSPSAELQCCAGWRQKDQECTIP-ICEGPDACQKDEVCVKPGLC
RCKPG-FFGAHCSSR--CPGQYWGPDCRES

PF00053 // ENSGT00730000110380_4_Domain_2 (151, 178)

CPCHPHGQCEPATGACQCQADRWGARCEFP
CACG-PHGRCDPATGV-CHCEPGWWSSTCRRP

PF00053 // ENSGT00730000110380_4_Domain_4 (213, 261)

CQCNTA----------AARCEQATGACV
CK---------PGWWG-RRCSFRCNCHGSPCEQDSGRCACRPGWWGPECQQQCECVRGRC
SAASGECTCPPGFRGARCELP----CPAGSHGVQCAHSCGHCKHNEPCSPDTGSCESCEP
GWNGTQCQQPCLPGTFGESCEQQCPHCRHGEACEPDTGHCQRCDP--GWLG---------
------------------------------------PRCEDPCPTGTFGEDCGSTCPTCV
QGSCDTVTGDCVCSAGYWGPSCNASCPAGFHGNNCSVPCECPEGLCHPVSGSCQPG--SG
SR-DTALIVGSLVPLLLLFLGLACCAC-CCWAPRSDLKDRPA-RDGATVSRMKLQ-VWGT
LT-SLGSTLPCRSLSSHKLPWVT---VSHHDPEVLFNHSFIEPPSAGWASDDSFSSDPES
-GEADEVPAYCVPPQEG-M-VPVVQAGSSEASL-AAGAFP-----PPEDASTPFAIPRTS
SLARAKRPSVSFAEGTKFAPQSRRSSGELSSPLRKPKRLSRGAQSGPE-GR--EAEESAG
PEEA----EAPE---SFPAAAS--PGDSATGHRRPPLGGRTVAEHVEAIE--------GS
VQESSGPVTTIYMLAGKPRG-----------SEGPIRSVFRHFGSFQKGQAE----A---
KVKRAIPKPPRQALNRKKGS-----------------------------PGLASGSVGQS
PNSA-PKAGLPGATGP--MAVRPE-----EA---VRGLGAGR---ESSRRAQEPISGCGS
PEQDPQKQAE---EERQEEPEYENVVPISRPPEP--------

-----------------------------------PLAAMGPELLLPLLLLWTQGTRESE
-----LDPKGQNVCRGSSPSAELLCCPGWKQKDGECTVP-ICEGPDACRKDEVCVKPGVC
RCKPG-FFGAQCSSP--CPSQYWGHDCRET

PF00053 // ENSGT00730000110380_4_Domain_2 (151, 178)

CSCYPHGKCDPATGVCQCQADRWGKNCESL
CSCG-PHGRCDPKTGQ-CRCDPGWWSSTCRRQ

PF00053 // ENSGT00730000110380_4_Domain_4 (213, 261)

CQCNA-----------AARCDPNTGSCV
CP---------LGWWG-RRCNFKCSCHKVPCAPDTGRCICPPGWLEPDCKR---------
------------------------SCTPGYYGSQCRQRCGHCKQNAPCSVDTGSCESCEP
GWNGTRCQQPCSPGTFGESCSQQCPRCRGGEPCQVETGYCEHCDP--GRLGS--------
-------------------------------------RCEDTCPSGFFGEACSFSCPTCI
QGACDAETGECICSAGYWGTSCNSSCLAGFYGSNCSLPCQCSDGLCDTVSGACLWG--HH
SK-EAFLIPAILGPLLLLLLGLACCAC-CCCTAPREPKDRPA-RGGTTLSRMKQQ-VWGA
LS-SLGSVLPCGSLSGYKLPWVT---VSHHDPEAPFNPSFIEQPSAGWASEDSFSSDSES
-GTEHEDRAYCMSSPKG-M-VPVA-----Q-ES-SEATFP-----PPEDTSTPFPIPRTS
SLARAKRPSVSFAEGTKFVSQNGRSSGELSSPIRKSKRLSRGAQPGAE-GR--ETEESTS
LEQA----KVEK---PPAAAAAAKTSNSAN-GHQFPQGGQKVAEPGETTE--------GN
VQESSDSVASIYMLAGMPEK-----------SESPVRSVLRRLGNLQKGQAE----P---
KVKSAIPKPPRRALGQKKAE--------------------------------ASGSGSQS
SV---LNANLVEPTES--AGVRLE-----EV---SRELGDGK---ESPRRAQEPVSSSSL
QEQNPQMQAE---E--EEEPLYENLHTSGRPES---------

-----------------------------------TPAAMGLGLLLPLLLLWTRGTQGSE
-----LDPNGQHVCVASSPSAELQCCAGWRQKDQECTIP-ICEGPDACQKDEVCVKPGLC
RCKPG-FFGAYCSSR--CPGQYWGPDCREN

PF00053 // ENSGT00730000110380_4_Domain_2 (151, 178)

CPCHPHGQCEPATGACQCQAQRWGAHCEFP
CTCG-PHGRCDPATGV-CRCEPGWWSPTCRRP

PF00053 // ENSGT00730000110380_4_Domain_4 (213, 261)

CQCNPE----------AARCEQATGACV
CK---------PGWWG-RRCSFRCTCHGSPCDQDSGRCACRPGWWGPECRQQCECVRGRC
SAASGQCTCPPGFRGARCELP----CPAGSHGVQCAQSCGHCKHNEPCSPDTGSCESCEP
GWNGTQCQQPCLPGTFGESCGQQCSHCRRGEACQPDTGHCQRCDP--GWLG---------
------------------------------------PRCEDPCPTGTFGEDCGSTCPPCV
QGACDAVTGECVCSAGYWGPSCNTSCPAGFHGNNCSVPCECPEGPCHPVSGSCQPG--SR
SR-DATLIASSLVPLLLLFLGLACCAC-CCWGTRSDLKDRPA-RDRATVSRMKMQ-VWGT
LT-SLGSTLPCGSLSSHKLPWVT---VSHHDPEVPFNHSFIEPPSAGWASDDSFSSDPES
-AEADEVPAYCVPPHEG-M-VPVAQAESSEASL-AGGAFP-----PPEDASTPFAIPRTS
SLARAKRPSVSFAEGTKFAPQSRRGSGELSSPLRKPKRLSRGAQSGPE-GR--EAEESTG
LEEA----ETDE---SLPAAAS--PGDSATGHRRPLLGGRTVAEHVEAIE--------GS
VQESSGPVTTVYMLVGTPRG-----------SEGPVRSVFRHFGGFQKGQAE----P---
KVKRAIPKPPRQALNRKKGS-----------------------------PGLASGSVIQS
PNSA-PKAGLPGATGP--MAVRPE-----EV---ARGLGAGT---ESSGRAEEPISGAGF
PKQDPQKQAE---EERQEEPEYENVVPISRPPEP--------

-------------------------------------AAMGLLIP-LVPLLWLRGVLGGP
----DLDPGGKNVCQAGSLPSEPVCCPGWRQEGRECTAGPLGEGEGKPRR-----GPPWA
RAAEG-PNEASPGAG--CPGQYWGPDCRRSCPCHPHGQCHPASGQCSCHSDRWGGICQFP

PF00053 // ENSGT00730000110380_4_Domain_3 (181, 211)

CSCG-AHGSCDPLSGA-CRCQPGWWGSACR

ENSGT00730000110380_4_Linker_3_4 (211, 213)

RP

PF00053 // ENSGT00730000110380_4_Domain_4 (213, 261)

CQCNPA----------GGLCHAALGSCL
CQ---------PGWWG-RRC

ENSGT00730000110380_4_Linker_4_5 (261, 293)

SFRCPCHGSPCSPTTGRCACRPGWWGPDCRDP

PF00053 // ENSGT00730000110380_4_Domain_5 (293, 333)

CDCGHGRC
HPDSGHCACHPGYRGLDCRQP----CPPGSFGLQC-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------

---------------------------------------MGLRLL-LLLLLWTQGTQESK
-----LDPNGQHVCLASSPSADIQCCPGWRQKDQECTIP-ICEGLDACREDEVCVKPGLC
RCKPG-FFGAQCNSR--CPGQYWGPDCREI

PF00053 // ENSGT00730000110380_4_Domain_2 (151, 178)

CACHPHGQCEPATGVCHCQADRWGGRCEFA
CACG-PHGRCDPATGA-CRCEPGWWSSTCRRP

PF00053 // ENSGT00730000110380_4_Domain_4 (213, 264)

CQCNPA----------AARCDQADGSCR
CE---------PGWWG-RRCSFRCACHGSPCTQETGRCVCRPGWWGPECRQQCECVRGPC
LSALGALQCPWRPQ-----------WGLPLSAPQCCHACGHCKHKEPCSVDTGSCESCEP
GWNGTQCHQPCPPGTFGESCGQLCPHCRLGEACQPDTGHCQHCDP--GWLG---------
------------------------------------PRCEDPCPTGTYGEGCSSVCHTCV
QGTCDAVTGECICHAGYWGPSCNTSCPPGFHGNNCSVPCECPEGPCNPVSGACQLGKGHH
SR-DAALIAGILVPLLLLLLGLIFCAC-CCWAARLDPKDRPA-SDGAAVTRMKLQ-VWGA
LS-SLGSALPCGSFSSHKLPWVT---VSHHDPEIPFNHSFIEPPSAGWASDDSFSSDPES
-GE-DESPAYCVPPQEG-M-VTVAHGEFPEASL-AGGPVP-----PPEDASTPFPIPRTS
SLARAKRPSVSFAEGTKFAPQSRRSSGEISSPLRKPKRLSRGAQLGPE-SQ--EAEESMD
SEKA----EMDE---TLPGAAS--PRDSATGRRRLPLGGRTVAERVEAIE--------GS
VLEGSGSVTTIYMLAGTPQL-----------SEGPVRSVLRRFGSFQKGQAG----P---
KVKSAIPKPPRRALSRNKGS-----------------------------PGLASGSAKQS
PSLA-PNEELTRSLES--VGTGPE-----EV---ARGLGDGT---KNSGRAQELTPDSGP
QEQDPQKLAD---EKEQEEPQYENVTPISGLPAP--------

---------------------------------------MGLGLLLPLLLLWTRGTQGSE
-----LDPNGQHVCVASSPSAELQCCAGWRQKDQECTIP-ICEGPDACQKEEVCVKPGLC
RCKPG-FFGAHCSSR--CPGQYWGPDCRES

PF00053 // ENSGT00730000110380_4_Domain_2 (151, 178)

CPCHPHGQCEPATGACQCQADRWGARCEFP
CACG-PHGRCDPATGV-CHCEPGWWSSTCRRP

PF00053 // ENSGT00730000110380_4_Domain_4 (213, 261)

CQCNTA----------AARCEQATGACV
CK---------PGWWG-RRCSFRCNCHGSPCEQDSGRCACRPGWWGPECQQQCECVRGRC
SAASGVGGG-------GRSIH----PPPPFPRSPSLPSCGHCKHNEPCSPDTGSCESCKP
GWNGTQCQQPCLPGTFGESCEQQCPHCRRGEACEPDTGHCQRCDP--GWLG---------
------------------------------------PRCEDPCPTGTFGEDCGSTCPTCV
QGSCDTVAGDCVCSAGYWGPSCNASCPAGFHGNNCSVPCECPEGLCHPVSGSCQPG--SG
SR-DTALIVGSLVPLLLLFLGLVCCAC-CCWAPRSDIKDRPA-RDGATVSRMKLQ-VWGT
LT-SLGSTLPCRSLSSHKLPWVT---VSHHDPEVPFNHSFIEPPSAGWASDDSFSSDPES
-GEADEVPAYCVPPQEG-M-VPVAQAGSSEASL-AAGAFP-----PPEDASTPFAIPRTS
SLARAKRPSVSFAEGTKFAPQSRRSSGELSSPLRKPKRLSRGAQSGPE-GR--EAEESTG
PEEA----EAPE---SFPAAAS--PGDSATGHRRPPLGGRTVAEHVEAIE--------GS
VQESSGPVTTIYMLAGKPRG-----------SEGPVRSVFRHFGSFQKGQAE----A---
KVKRAIPKPPRQALNRKKGS-----------------------------PGLASGSVGQS
PNSA-PKAGLPGATGP--MAVRPE-----EA---VWGLGPGT---ESSRRAQEPISGCGS
PEQDPQKQAE---EERQEEPEYENVVPISRPPEP--------

---------------------------------------MGLRLLLPLLVFQLWGSQGSL
-----LDPSGQHVCVGSSPS-ELQCCPGWRQKDHECTIP-I

PF07974 // ENSGT00730000110380_4_Domain_0 (102, 132)

CEGLDACKEGEVCVKPGLC
RCKPG-FFGAQCSSR--CPKQYWGPDCRESCPCHMHGQCEPATGKCQCQPDHWGTHCEFP
CTCS-SHGHCDPATGV-CRCDPGWWSSTCGRP

PF00053 // ENSGT00730000110380_4_Domain_4 (213, 266)

CQCNPA----------AARCEQANGLCL
CE---------PGWWG-RRCSFRCS

ENSGT00730000110380_4_Linker_4_5 (266, 293)

CHGSPCVQDTGRCTCRPGWWGPECRQR

PF00053 // ENSGT00730000110380_4_Domain_5 (293, 339)

CECLRGHC
SATSGQCTCPPGFRGTRCELL----CPAGSYGLQCRNSCGHCKQKEPCSPDTGDCESCEP
GWNGTRCHQPCPPGTFGEGCRQQCPHCRLGEACQPDSGHCQHCDP--GWVG---------
------------------------------------PRCDEPCPTGTFGEGCSFACPPCV
QGTCDAVTGDCVCSAGYWGLSCNMSCPSGFHGHNCSLPCECPEGPCHPVSGACQPG--PH
SQ-EAALLAGILVPLLLLLLGLACCAC-CCWAARLDPKDRPA-GDGALLSRMKLQ-AWGA
LA-NLGALLPCGSLSSHKLPWVT---VSHHDPEIPFNHSFIEPPSTGWVSDDSFSSDPES
AGEEEEGPAYCVPPQE--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------

---------------------------------------MGLGLLLPLLLLWTRGTQGSE
-----LDPNGQHVCVASSPSAELQCCAGWRQKDDECTIP-ICEGPDACQKDEVCVKPGLC
RCKPG-FFGAYCSSR--CPGQYWGPDCRES

PF00053 // ENSGT00730000110380_4_Domain_2 (151, 178)

CPCHPHGQCEPATGACQCQADRWGARCEFP
CACG-PHGRCDPATGV-CRCQPGWWSPTCRRP

PF00053 // ENSGT00730000110380_4_Domain_4 (213, 261)

CQCNPE----------AARCEQATGACV
CK---------PGWWG-RRCSFRCTCHGSPCEQDSGRCACRPGWWGPECRQQCKCVRGRC
STASGQCTCPPGF-------------------------CGHCKHNEPCSPDTGSCESCEP
GWNGTQCQQPCLPGTFGESCGQQCSHCRHGEACQPDTGHCQRCDP--GWLG---------
------------------------------------PRCEDPCPTGTFGEDCGSTCPTCV
QGACDAVTGECVCSAGYWGPSCNASCPAGFHGHNCSVPCECPEGPCHPVSGSCQPG--SR
SR-DATLIASSLVPLLLLFLGLACCAC-CCWATRSDLKDRPA-RDRATVSRMKMQ-VWGT
LT-SLGSTLPCGSLSSHKLPWVT---VSHHDPEVPFNHSFIEPPSAGWASDDSFSSDPES
-VEADEVPAYCVPPHEG-M-VPVAQAESSEASL-AAGAFP-----PPEDASTPFAIPRTS
SLARAKRPSVSFAEGTKFAPQSRRGSGELSSPLRKPKRLSRGAQLGPE-GR--EAEESTG
LEEA----ETDE---SLPAAAS--PGDSATGPRRPPLGGRTVAEHVEAIE--------GS
VQESSGPVTTVYMLVGTPRG-----------SEGPVRSAFRHFGGFQKGQAE----P---
KVKRAIPKPPRQALNRKKGS-----------------------------RGLASGSVSQS
PNSA-PKAGLPGVTGP--MAVRPE-----EV---ARGLGAGT---ENSGRAQEPISGAGF
PKQDPQKQAE---EERQEEPEYENVVPISRPPEP--------

------------------------------------------------------------
---------------------------------------------------EVC-VPGLC
RCKPRVFFGALCNSS--CPGQYWGPDCREL

PF00053 // ENSGT00730000110380_4_Domain_2 (151, 177)

CACHPHGKCEPATGMCSCQANRWGDNCQFA
CSCDNRHGLCDPKTGT-CHCEPGWWSSTCQRQ

PF00053 // ENSGT00730000110380_4_Domain_4 (213, 266)

CQCSQS----------SRSCDPATGICL
CK---------HGWWG-RRCSFNCDCNGLPCAQESGRCTCPPGWWGLKCQHRCKCVRGNC
SVNYGHCTCPPGFHGQHCELP----CPAGTYGPQCRQSCGHCKQNEPCSADTGNCLSCEP
GWNGTQCQQPCAAGTFGESCRQQCPRCWMGEACQPDTGHCQRCDP--GWWG---------
------------------------------------PRCEDPCPAGSFGEGCDSTCPICV
HGACDTVTGECVCNVGFWGPSCNNSCPSGFHGNNCSVACECPEGSCHPVSGACQMG--SR
SR-DATLIAGILVPLLLLLLGIACYAC-CCWATRRGYKDRPV-RNGAAVSRMKLQ-VWGA
LS-NLGSMFPCGSLSNHKLPWVT---VSHHDPEVPFNHSFIEPPSAGWASDDSFSSDPES
-AEEDEGPAYCVPPQEG-I-GPVAQADSLKANL-PGSPLP-----LPEDASTPFAIPRTS
SLARAKRPSVSFAEGTKFAPQSCRSSGELSSTLRKPKRLSRGAQPGPE-GQ--EAKESTG
PEQA----GKEE---VPPGVTS--PRDSAVGRCWLPLGSRTVAERVEAIE--------SN
VQESSDSVTTIYMLAGTPQG-----------PEGPVRSVLRRFGNFQKGQAV----P---
KVKSAIPKPPRRALSRQKGS-----------------------------PGLTSGSANQS
PRSAPPNEELPGTLES--ASARPE-----EV---VSGMGDDI---KNSGQAQEPAPEGSS
PEQESQKLV----EEGQGEPQYENVAPISVHPVH--------

---------------------------------------MGLRLLLPLLLLWSPGTQGSE
-----LDPKGKHVCMASSPSAELQCCPGWRQKDQECTIP-ICEGLDACREDEVCVKPGLC
RCKPG-FFGAQCSSR--CPGQYWGPDCRES

PF00053 // ENSGT00730000110380_4_Domain_2 (151, 178)

CPCHPHGQCEPATGVCQCQADRWGSRCEFA
CFCG-PHGRCDPATGA-CRCEPGWWSPTCRRP

PF00053 // ENSGT00730000110380_4_Domain_4 (213, 261)

CQCNPA----------AARCDPATGACL
CE---------PGWWG-RRCSFRCACNGSPCAQESGRCACRPGWWGPECRQQCECARGRC
SAASGQCACPPGFRGARCELP----CAAGSYGPQCRDRCGHCKQSEPCSPDTGSCASCEP
GWNGTQCHQPCSPGTFGESCRQQCPRCRLGEACQPDTGHCQRCDP--GWLG---------
------------------------------------PRCEDPCPTDTFGEGCGSPCPTCV

PF00053 // ENSGT00730000110380_4_Domain_7 (481, 521)

QGACDAVTGECVCSAGYWGPSCNNSCPSGFYGNNCSVPCECEEGSCHPVSGACQLG--PR
SQ-DAALIAGILVPLLLLLLGLACCAC-CCWAARLDPKDRPV-RDGTAVSRMKLQ-VCGA
LA-SLGSVLPCGSLGTHKLPWVT---VSHHDPEIPFNHSFIEPPSAGWASDDSFSSDPES
-GEEDEGPAYCVPPQEG-M-APVAQEASSEASL-TGGPFP-----PPEDASTPFAIPRTS
SLARAKRPSVSFAEGTKFAPQSRRSSGELSSPLRKPKRLSRGAQTGPE-GQ--EAEESIG
PEQA----ETDE---APPAAAS--PRDSATGRRWVPLGGRTVAERVEAIE--------GS
VQENSGSVTTIYMLAGTPRG-----------SEGPVRSVLRRFGSFQKGQAE----P---
KVKSAIPKPPRRALSRNKGS-----------------------------PGLASGSPSQS
LNSA-PNAELTGAVES--TGVRSE-----EM---ARGLGTGA---ESSGRAQELVSGGSP
PEQDPQKQAE---EEGQEEPQYENVVPISGPPEP--------

---------------------------------------MGLGLG-LLLLLWTQGALGSQ
-----LDPKGQHVCVASSPSAELQCCPGWRQKDRECTIX-XXXXXXXXXXXXXXXXXXX-
XXXXXXXXXXXXXXX--CPAQYWGPDCRKS

PF00053 // ENSGT00730000110380_4_Domain_2 (151, 178)

CACHPHGQCEPATGECHCQANRWGDRC

ENSGT00730000110380_4_Linker_2_3 (178, 181)

EFT

PF00053 // ENSGT00730000110380_4_Domain_3 (181, 203)

CACS-PHGRCDP-TGV-CRCEP

ENSGT00730000110380_4_Linker_3_4 (203, 213)

GWWEPTCHRQ

PF00053 // ENSGT00730000110380_4_Domain_4 (213, 278)

CSCNLA----------ASRCDPATGACL
CQ---------PGWWG-RRCSFRCACHGSPCAPESGRCACLPGRWGLSCRQVCQCARGRC
SAASGQCACPPGYRGERCELP----CPAGRYGAQCLHSCGHCQQNEPCAPDTGSCESCEP
GWNGTQCHQRCPPGTFGENCRQQCPRCRLGESCQPDTGHCEHCNP--GWQG---------
------------------------------------PRCEEPCPADTFGESCSFTCPTCL
QGTCDAVTGDCVCNAGYWGPSCNTSCPFGFYGDNCSVPCQCPEGPCHPVSGACQHG--LR
GQ-DAALIAGILVPLLLLLLGLACCLC-CFWAARLDPKDRLP-RDGTAVSRVKLQ-MWGA
LT-SLGSVLPCGSLRSHKLPWVT---VSHHDPEVPFNHSFIEPPSAGWPSDDSFSSDPES
-AEEDEDPAYCVP-----M-TSVVQAESPDTSL-AAGSFP-----PPEDASTPFAIPRTS
SLARAKRPSVSFAEGTKFTPQSHRSSGELASPLRKPKRLSRGAQPSSE-GQ--QADVSLG
PEAA----ESEE---TPPGATS--SGDSAAGCQQLPLGGRTVAERIEAIE--------SS
VQEHSGLMTTIYMLAGTPWG-----------PEGLVRSVLRHSASRAPTQ----------
---------PCQLLEGSQAA----------------------------------------
-----P-------------R------------------AGTT---QEPRSTEGPAPGGGL
PEQDPPKLVE---DQGQEEPQYENVAHISGPPVP--------

MAARLSALVSSGKALEGSREGVGSRGGQTNPSPPAGLAAMGLRLLVSLLLLWTQGTQGSN
-----LDPNGRHVCTAGSPSAELQCCPGWRQKDQECTIP-ICEGLDACREDEVCVKPGLC
RCKPG-FFGAQCNSR--CPSQYWGPDCRET

PF00053 // ENSGT00730000110380_4_Domain_2 (151, 178)

CACHPHGQCEPATGVCHCQAERWGSRCEFQ
CDCG-PTGXXX-------------------------------------------------
-------------------------XXXSPCAQETGRCVCRPGRWGPECRYECECVRGRC
NAVSGLCACPPGFRGARCELP----CPAGSYGPHCRDSCGHCKQNEPCSADTGSCESCEP
GWNGTQCHQPCPPGTFGESCRKQCPRCRLGEACQADTGHCQRCDP--GWLG---------
------------------------------------PRCEDPCPLGTFGEGCTSTCPTCV
QGACDAVTGECVCDIGYWGPSCNTSCPSGFHGNNCSIPCECPGGSCHPVSGACQLG--PH
GQ-DAALIAGILVPLLLLLLGIAFCAC-CCWAARLDPKDRPA-RDEAAVSRVKMQ-VWGA
LT-SLGSALPCGSLSSHKLPWVT---VSHHDPEIPFNHSFIEPPSAGWASDDSFSSDPES
-GEEDEGPAYCVPPQEG-M-ATVAHGEFPEASL-AGGPIP-----PPEDASTPFPIPRTS
SLARAKRPSVSFAEGTKFAPQSRQSSGELSSPLRKPKRLSRGAPLSPE-SQ--EAEESMG
PEKA----ETDE---TLPGAAS--PRDPAIGRRRLPLGGRTVAERVEAIE--------GS
VSEGSGSVTTIYMLAGTPQV-----------SEGPVRSVLRRFGSFQKGQAE----P---
KVKSAIPKPPRRALSRNKDS-----------------------------PGLASGTASQS
PNLA-PNHELTRALES--AGTGPE-----EV---ARGLGDGT---KNSGRAQELAPEGGP
QEQDPQKLSD---EEGQEEPQYENVAPISGPPAP--------

---------------------------------------MGLELLLPLLLLWTQGTQESE
-----LDPKGQNVCRGSSPLAKLVCCPGWKQKDGDCTVP-VCEGLDACRKDEVCVKPGFC
RCKPG-FFGAQCSSS--CPDQYWGPDCRET

PF00053 // ENSGT00730000110380_4_Domain_2 (151, 178)

CACYPHGKCDPATGVCQCHAGRWGDNCESQ
CSCG-PHGHCNPKTGQ-CRCDPGWWSATCRRQ

PF00053 // ENSGT00730000110380_4_Domain_4 (213, 261)

CQCNP-----------AARCDPDTGNCL
CP---------LGMWG-RRCNFRCHCHNSPCAPDTGRCMCQAGWLEPDCKRPCAPGY---
-------------YGLQCPNSRLPACKAGAYAAQLNPQCGHCKHNAPCSVDTGSCESCEP
GWNGTRCQQPCSPGTFGENCSQQCPHCRDGEPCQIETGDCEHCDP--GRLGP--------
-------------------------------------RCEDTCPSGTFGEGCSSPCPTCV
QGACDAVSGECVCSAGYWGTSCNSSCLSGSYGNNCSLPCQCSDGLCDPVSGACLWG--RK
---KSLLIGSILGPLLLLLLGIACCAY-CHCATSREPKDRPA-RGGTALSRMKQQ-FWGA
LS-SLGSVLPCGSLSGYKLPWTV---WHVEKKVG--------RP----------------
-----GCSQALLSPLPG-M-VPVAPAELSPRES-SEATFP-----PPEDASTPFPIPRTS
SLARAKRPSVSFAEGTKFVSQSGRSSGELHSPARKPKRLSRGAQPGPE-GR--ETEESTS
LEQA----KMDK---APTAA--ARSGNSAN-GHQAPCGSQKVAKPGETTE--------GS
MQESSDSAASIYMLVGMPEK-----------SKGPVRSVLRRLGNFQKGQEE----P---
KVKSAIPKPPRRALGQKKGS-----------------------------SGMVSGSASQR
------------AVEP--VGVKPE-----EV---SRGLGDGR---ESPGRPQELISSSSL
ADQDPQKHVE---EEEQEEPLYENVHTSGRPES---------

----------------------------AHSNPLTALAAMGLRLLLPLLLLWTQRTEGSE
-----LDPNGRHVCMDNSPSAELQCCPGWRQKDRECTIA-I

PF07974 // ENSGT00730000110380_4_Domain_0 (102, 132)

CEGPDACREDEVCVKPGLC
RCKPG-FFGAQ

ENSGT00730000110380_4_Linker_0_2 (132, 151)

CNSR--CPGQYWGPDCRES

PF00053 // ENSGT00730000110380_4_Domain_2 (151, 178)

CACHPHGQCEPDTGVCRCQANRWGSRCEFE
CTCS-PHGRCDPKTGA-CHCDAGWWSTKCHHR

PF00053 // ENSGT00730000110380_4_Domain_4 (213, 260)

CQCNPV----------AARCDQATGNCL
CE---------VGWWG-RRCSFRCNCHGSPCAKESGRCACRPGWWGPECRQRCECLRGRC
SADSGQCACPPGFHGLRCELP----CPAGLLRGAVQPHCGHCEQDEPCSADTGSCKSCEP
GWNGTQCLQPCPPGTFGESCGQQCPRCRRGEACQPDTGHCPSCDP--GWLG---------
------------------------------------PRCEDPCPSGTFGEGCGSTCPTCV
QGACDAVTGECVCNAGYWGPSCNVSCPSGFHGNNCSAPCECPEGPCHPVSGACQLG--KH
SQ-DATLIAGILVPLLLLLLGIACCAC-CCWAARLDPKDRPA-RDGAAVSRKKLQVLWET
LT-GLGFALPCRSLSSHKLPWVT---VSHHDPEIPFNHSFIEQPSAGWASDDSFSSDYDC
-GEEDEDPAYCVPPQEG-M-VPVAQAASPEASL-GDGPFP-----PPEDASTPFAIPRTS
SLARAKRPSVSFAEGTKFAPQNRQSSGELSNPLRKSRRLSRGGQPGPE-SQ--EAEESTG
PENT----ERDK---APPGAPS--PKDSATGHRRLPLCGRTVAERVEAIE--------SS
VQESSGSVTTIYTLAGTPRE-----------SEGPVRSVLRRFGSFQKGQAE----P---
KVKSAIPKPPRRALSRNKGR-----------------------------PGLASGSASQS
PGPA-PNEEPTGASQP--AGTGPE-----EV---ASGLRDGI---KSSGRVQELGPG-GP
PKQDPQKLAD---EEGQEEPQYENVAPISRPPEP--------

------------------------------------------------------------
------------------------------------------------------------
-----------------CPEQYWGHDCKRSCPCHPNGSCDPVSGHCTCDPNHWGGLCQFP

PF00053 // ENSGT00730000110380_4_Domain_3 (181, 210)

CQCG-PHGRCDPLTGL-CRCEPGWWAPNC

ENSGT00730000110380_4_Linker_3_4 (210, 213)

RKQ

PF00053 // ENSGT00730000110380_4_Domain_4 (213, 261)

CQCNPS----------TSHCDPLTGLCR
CL---------PGWWG-RRCSFKCSCNVSPCAQETGKCECLPGFWGPACQRRCDCGHGSC
SPASGHCTCEPGYQGRSCRDP----CPAGKYGSQCVHSCGSCKRSQPCSPVDGFCLACQP
GWNGTLCKDPCAPGFHGDGCLQPCPRCQHGEPCDPQTGSCLRCDP--GWMG---------
------------------------------------PSCNNSCPVGTFGDGCQFLCPEC

PF00053 // ENSGT00730000110380_4_Domain_7 (480, 521)

V
SGSCDPVTGVCICQAGYWGDSCNDTCPEGYFGVNCSSPCQCSRGTCDAVQGDCVLNTGLK
--DHGTLAAAILVPLLLLL--LCVACC-CCGAGSADARDRAAVPDDDVVARMKHH-VQGV
LA-NLSALMPCFNLGTSKLPKVT---VSHHDVEIPYNPSFIEPPSSAWVSDSSFS-SFDT
---DNEGPEYSVPPREGI--PLLGGAELQDGASPPGQALPDPSAFDSEGCLAALRLPPHS
SIAKAKRPSVSFAEGTKFGA------AETPSPSRKPKAPWGPSRLTPPPGDVAA--EPPS
ERPASDCYENPEPLSKGDESHRPSPRATPGGRRRMVSSTRHVAQRVEALEAAAKSGSWEA
KGKKEHNVTTIYMMVGTAGQDPK----AEGSGEGPVQAVLKRLGSLQRGKWAAKEEPKAR
RSMEAIQKPPRRAL----------------------------------------------
------------------------------------------------------------
------------------------------------------

---------------------------------------MGPELLLPLLLLWTPGTQGSK
-----LDPKGQNVCRGSSPFAELLCCPGWKQKDQECTVP-ICEGLDACRKDEVCVKPGLC
RCKPG-FFGAECSSA--CPGQYWGPDCRET

PF00053 // ENSGT00730000110380_4_Domain_2 (151, 178)

CSCYPHGKCDPATGVCQCQADRWGKNCESL
CSCG-PHGHCDPKTGQ-CRCNPGWWSATCRRQ

PF00053 // ENSGT00730000110380_4_Domain_4 (213, 261)

CQCNP-----------AARCDPDTGTCL
CP---------LGWWG-RRCNFKCPCHKFPCVPDTGRCICPPGWQEPDCKRP--------
--------------------------------------CGHCKQNAPCSVDTGSCESCEP
GWNGTRCQQPCSPGTFGESCSQQCPRCWDGEPCQTETGHCEHCDP--GKLGPRPAVPS--
-----------------------------PSLNLASPRCEDTCPNGTFGLGCSFPCPTCI
HGACDAETGECVCSAGYWGTRRDPQVGRGN----SELKTAVCGGGPDYLASPVPTG--LH
GK-QAFLIAGILGPLLLLLLGIACCAY-CCCTTRREPKDGPA-RGGTTLSRMKQQ-VSGA
LS-SLGSVLLCGSLSGYKLPWVT---VSHHDPEAPFNPSFIEQPSAGWASEDSFSSDSES
-GAENEDSAYCVSSLKG-T-APVA-----QIES-SEATFP-----PPEDTSTPFPIPRTS
SLARAKRPSVSFAEGTKFVSQSGRSSGELSSPIRKSKKPSRGAQPGPE-GQ--ETEESTS
PEQA----KVDK---APTAAAAAAA--AKP-SSSFPRGGQKVAEPGETTE--------GN
VQESSASLASVYMLVGMPEK-----------SQGHVRSVLRRLGNFQKSQAE----P---
KVKSAIPKPPRRALGQKKGS-----------------------------PGLASGSASQS
PGSA-LNASLVEAAES--AGVGPE-----EV---SRGLGDGR---ESPGKTQEPVPSSSL
QEQAPQKQAE---EEGQEEPLYENVHTCGRPES---------

---------------------------------------MGLGLLLPLLLLWTRGTQGSE
-----LDPNGQHVCVASSPSAELQCCAGWRQKDQECTIP-ICEGPDACQKDEVCVKPGLC
RCKPG-FFGAYCSSR--CPGQYWGPDCREN

PF00053 // ENSGT00730000110380_4_Domain_2 (151, 178)

CPCHPHGQCEPATGACQCQAHRWGAHCEFP
CTCG-PHGRCDPATGV-CRCEPGWWSPTCHRP

PF00053 // ENSGT00730000110380_4_Domain_4 (213, 261)

CQCKPE----------AARCEQATGACV
CK---------PGWWG-RRCSFRCTCHGSPCDQDSGRCACRPGWWGPECRQQCECVRGRC
SAASGQCTCPPGFRGARCELP----CPAGSHGVQCAHSCGHCKHNEPCSPDTGSCESCEP
GWNGTQCQQPCLPGTFGESCGQH-------------------------------------
------------------------------------------------------------
---------------------CNTSCPAGFHGNNCSG-------PCHPVSG---------
-R-DATLIASSLVPLLLLFLGLACCAC-CCWATRSDLKDRPA-RDRATVSRMKMQ-VWGT
LT-SLGSTLPCGSLSSHKLPWVT---VSHHDPEVPFNHSFIEPPSAGWASDDSFSSDPES
-AEADEVPAYCVPPHEG-M-VPVAQAESSEASL-AGGAFP-----PPEDASTPFAIPRTS
SLARAKRPSVSFAEGTKFAPQSRRGSGELSSPLRKPKRLSRGAQSGPE-GR--EAEESTG
LEEA----ETDE---ALPAAAS--PGDSATGHRRPPLGGRTVAEHVEAIE--------GS
VQESSGPVTTVYMLVGTPRG-----------SEGPVRSVFRHFGGFQKGQAE----P---
KVKRAIPKPPRQALNRKKGS-----------------------------PGLASGSVSQS
PNSA-PKAGLPGATGP--MAVRPE-----EV---ARGLGAGT---ESSGRAQEPVSGAGF
PKQDPQKQAE---EERQEEPEYENVVPISRPPEP--------

----------------------------TNPSPSAALAAMGLRLLLLLLLFWTQGTQGSK
-----LDPNGRHVCVASSPSAELQCCPGWRQEDAECTIP-I

PF07974 // ENSGT00730000110380_4_Domain_0 (102, 132)

CEGLDACQEHEVCVKPGLC
RCKPG-FFGAQ

ENSGT00730000110380_4_Linker_0_2 (132, 151)

CSSR--CPGQYWGPDCRES

PF00053 // ENSGT00730000110380_4_Domain_2 (151, 178)

CPCHPHGRCEPATGACHCQADRWGDRCEFA
CACG-PHGRCDPATGA-CHCEPGWWATTCHRP

PF00053 // ENSGT00730000110380_4_Domain_4 (213, 260)

CQCNLA----------AARCDPVTGTCL
CE---------PGWWG-RRCSFRCVCHGSPCEQGSGRCTCRPGWWGPGCRERCLCVRGRC
SATSGQCACPPGFHGERCELQ--LGVAPGSSGLEGAGCCGHCKQNKPCAPDTGSCESCKP
GWNGTRCHQPCPPGTFGESCRQQCPR

PF00053 // ENSGT00730000110380_4_Domain_6 (387, 476)

CQFGESCQPDTGHCHRCDP--GWQG---------
------------------------------------PRCEEPCPPGTFGKDCGFTCPTCI
QGTCDAVTGDCVCSAGFWGPSCNTSCPSGFHGDNCSVPCQCQEGPCHPVSGACQHG--LH
GQ-DAALIAGILVPLLLLLLGIACCAY-CCWAARMDPKDRST-TDGATVSRVKLQ-VWGA
LT-SLGSVLPCGSLSSHKLPWVT---VSHHDPEIPFNHSFIEPPSAGWASDDSFSSDPES
-GEEDEGPAYCVPPQEG-M-APVAQVESPEASL-ATGPFP-----PPEDASTPFAIPRTS
SLARAKRPSVSFAEGTKFAPQSRRSSGELSSPLRKPKRLSRAAQPGPE-GQ--EAEESTD
PEPA----ETDK---APSGAAS--PRDSAIGRRQHPLGGRTVAERVEAIE--------GS
VQENSGPVTTIYMLAGTPRG-----------SEGPVRSVLRRFGSFQKGQSE----P---
KVKSAIPKPPRRALSRNKGS-----------------------------PGLASGCASQS
PGSA-PYEELTGALES--VRARPG-----EV---ARGLGDGI---ESPGRAQELAPAGAL
PEQAPQKLAE---EEGQEEPQYENVAPISGPSEP--------

---------------------------------------MGLGLLLPLLLLWTQGTQGLA
-----LDPNGRHVCVASSLSAEPQCCPGWRQKDRECTIP-I

PF07974 // ENSGT00730000110380_4_Domain_0 (102, 132)

CEGQDACEEDEVCVKPGLC
RCKAG-FFGARCSSR--CPGQYWGPDCRESCICHPNGQCEPATGACHCKADRWGDLCEFQ
CACG-PHGRCDPATGA-CHCEPGWWTPTCQRQ

PF00053 // ENSGT00730000110380_4_Domain_4 (213, 260)

CQCNLA----------AASCDPNTGACL
CE---------PGWWG-RRCSFRCRCHMSPCAQESGRCACLSGWWGSECQNRCLCVRGHC
SAASGECACPPGFQGLRCERP----CPAGRYGAKCRNSCGHCKQNAPCATDTGSCESCEP
GWNGTQCHQPCPPGTFGESCRQQCPHCQLGESCQPDTGHCQRCDP--GWQG---------
------------------------------------PXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXCNTSCPPGFHGDNCSVPCQCPEGPCHPVSGACQRX--XX
XXXXXXXXXXXXXXXXX-XXXXXXXXX-XXXXXXXXXXXXPT-TDGATVSRVKLQ-VWGA
LT-NMGSLLPCGSISSHKLPWVT---VSHHDPEIPFNHSFIEPPSAGWASDDSFSSDPES
-GEEDEGPAYCVPPREG-M-APVAQVESPEASL-AAGPFP-----PPEDASTPFAIPRTS
SLARAKRPSVSFAEGTKFAPQTRRSSGELPSPLRKPKRLSRAAQPGPE-GQ--EAEESTD
PEPA----EVDK---ALSGAAS--PRASGFGHRQLPLGGRTVAECVEAIE--------GN
MQENSGPVTTIYMLAGTPRG-----------SEGPVRSVLRHFGSFQKGQAE----P---
KVKSAIPKPPRRALSRNKGS-----------------------------PGLASGSASQG
PGSA-PYEELPGALAS--VRAGPE-----EV---ARGLGDGT---ESPGKAQELASGGGL
PEQTPQKLAE---EEGQEEPQYENVIPISGRSEP--------

------------------------------------------------------------
-------------------------MPGGG--TSARPAA-ICEGLDACREDEVCVKPGLC
RCKPG-FFGAQCNSR--CPGQYWGPDCREV

PF00053 // ENSGT00730000110380_4_Domain_2 (151, 178)

CACHPHGQCEPATGVCHCQPDRWGDRCEFP
CACG-PHGRCNPETGA-CRCDPGWWSPTCRRP

PF00053 // ENSGT00730000110380_4_Domain_4 (213, 261)

CQCNPA----------AARCNQATGSCL
CE---------PGWWG-RRCSFRCACHGSPCAQESGRCACRPGWWGPECREPCECVRGRC
SAASGQCTCPPGFRGVRCELP----CPAGRYGLQCRDSCGQCKQNKPCSADTGSCEACEP
GWNGTQCHQPCPPGTFGENCRQQCPHCRLGEACQPDTGHCQHCEP--GWRG---------
------------------------------------PRCEDPCLIGTFGEACGSTCPTCV
QGTCDAVTGECVCNAGYWGPSCNTSCPSGFHGNNCSVPCECPEGSCDPVSGACQLG--SH
SQ-DAALIAGILVPLLLLLLAITCCAC-CCWAARLDPKDRPV-RDGTAMSRMKLQ-VWEA
LTSSLGSALPCGSLSSHKLPWVT---VSHHDPEIPFNHSFIEPPSAGWASDDSFSSDSES
-GEEDEGPAYCVPPQEG-M-VSAAPAESSEASL-AGGPFP-----PPEDASTPFAIPRTS
SLARAKRPSVSFAEGTKFAPQSRRGSGELSSPLRKPKRLSRGTQPGPE-SQ--EIEEPTG
PQV-----ETDG---APPGTAS--PRDSAAGRRRRPLGGPHLVAGQWLSV-------WKP
SRAASRRAQALSAQSICWQG-----------HRGDLRALSG-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------

------------------------------------------------------------
-----------HSFLPHSPSAELQCCAGWKQKDQECTIP-ICEGLDACREDEVCVKPGLC
RCKPG-FFGAQCSSR--CPGQYWGPDCRES

PF00053 // ENSGT00730000110380_4_Domain_2 (151, 178)

CPCHPYGQCEPATGVCQCQADRWGSRCEFA
CDCG-PHGRCDPATGA-CRCEPGWRSPTCRRP

PF00053 // ENSGT00730000110380_4_Domain_4 (213, 261)

CLCNQA----------TARCEPTTGACL
CE---------PGWWG-RRCSLRCSCHGSPCAQETGRCACQPGRWGPDCGQLCECVRGHC
SAASGQCACPPGFRGARCELP----CPAGRYGIQCRDRCGHCKQNEPCSPDTGNCVSCEP
GWNGTQCHQPCPPGTFGESCKQQCPHCRLGEACQPDTGHCQRCDP--GWLG---------
------------------------------------PRCEDPCPTGTFGEGCSFPCPTCV
QGACDAVTGECVCSAGYWGPSCNTSCPSGFHGNNCSVPCECPEGPCHPVSGVCQLG--PH
SQ-DSALIVGILVPLLLLLLGLACCAC-CCWAAHSDPKDRPV-SNGAAVSRMKLQ-VWGA
LT-TLASALPCFSLSTHKLPWVT---VSHHDPEIPFNHSFIEPPSAGWASDDSFSSDPES
-GEEDEGPAYCVPPQEG-S-SPAAYLAPEHPXX-XXXXXX-----XPEDASTPFAIPRTS
SLARAKRPSVSFAEGTKFAPPSRQSSRELSSPLRKPKRLSRGAQTGPE-GQ--EAEDSTG
PEQA----EMDE---APPAAAS--PKDSATGRRWLPPGGRTVAERVEAIE--------GS
VQDSSGPVTTIYMLAGTPQG-----------SEGPVRSVLRHFGSFQKVQAE----P---
KVKSAIPKPPRRALSRNKGS-----------------------------PGLASGSSGQS
LNSA-LSTELSG------------------------------------------------
------------------------------------------

---------------------------------------MGLGLVFPLLLLWTRETQGST
-----LDPAGQHVCRGSSPS-ELQCCPGWRQKDEECTIP-ICEGPDACKKDEVCVKPGLC
RCKPG-FFGAQCSSR--CPGQYWGPDCRET

PF00053 // ENSGT00730000110380_4_Domain_2 (151, 178)

CPCHPRGQCESATGVCRCQPNYWGRLCEFT
CTCG-PHGQCDQKTGL-CHCDPGWWSPTCRRP

PF00053 // ENSGT00730000110380_4_Domain_4 (213, 261)

CQCNP-----------AARCDQTTGACL
CP---------SGWWG-RRCSFKCSCHNSPCVQDSGHCTCLPGWWGPECNHRCQCVRGQC
SVTSGHCSCPPGFYGARCELP----CNPGHYGVQCRESCGHCQLNATCSPVTGTCESCKP
GWNGTQCKQPCPLGTFGERCREQCPRCRLGEPCHAETGHCQRCDP--GWLG---------
------------------------------------HRCENSCPLGSFGEGCSSICPTCV

PF00053 // ENSGT00730000110380_4_Domain_7 (481, 521)

QGTCDAVTGECVCSAGYWGTSCNNSCPPGFYGNNCSTPCQCSEGLCHPVSGACQLG--QH
G--KNALIVGILVPLLLLLVGLICCVY-CCSATRLDPKDRPE-RNGAALFRMKQQ-VWGA
LT-SLGSSLPCGSLSNYKLPWVT---VSHHDPEIPFNHSFIEPPSAGWASDDSFSSDPDS
-GEEDENHTYSVPPREG-M-VSVTQEESPAASL-PGGPFP-----PPEDASTPFPIPRTS
SLARAKRPSVSFAEGTKFAPQNGRNSGDLSSPIRKPKRLSRGAQPRPE-GQ--EAEEPAG
PEQA----NTEE---DTPTATS--PGDAATS-HQLPPTNQTVAECVETTN--------GS
IQESSGSVATIYMLAGTPQK-----------PEGPVLSVFRRLGNYQKDQAV----P---
KVKSAIPKPLRRSLGRNQGSSGSGSA----------------------------------
-----PEAMLSG--TVESTEVRPE-----EA---SRGMGDGI---ESLTTVQEPVSGNSS
LEQCSQKQAE---EKEQEEPLYENYVPMSVLPQH--------

---------------------------------------MRLGLLLPLLLLWTRGTQEST
-----LNPEGQHVCPGSSPSADLQCCPGWRQKDQECTIP-ICEGQDACRKDEICVKPGLC
RCKPG-FFGAQCSSR--CPGQYWGPDCRET

PF00053 // ENSGT00730000110380_4_Domain_2 (151, 178)

CPCHPHGHCEPATGVCQCQAGRWGSLCEFS
CSCS-SHARCDPATGT-CHCDPGWWSPTCQRT

PF00053 // ENSGT00730000110380_4_Domain_4 (213, 261)

CQCNP-----------RAHCDPVTGACL
CP---------LGFWG-RRCNFHCTCHTSPCLQDNGRCTCLPGWWGPECRRRCECVRGQC
NVVSGQCTCPPGFHGKHCELP----CDPGRYGDQCSERCGHCKPNATCSPITGSCDSCKP
GWNGTQCKQRCPPGTFGNSCSQQCPRCKLGEPCQADTGHCQRCEP--GWLG---------
------------------------------------PRCEDPCPTGTFGEGCSSTCPPCV
QGVCDVVTGECVCNTGYWGTSCNSSCPSGFHGSNCSLSCQCSEGLCHPVSGACQLG--RH
G--KNALIAGILVPLLLLLLGMVCCVY-CRWATRLDPKDRPA-RDGAALSRMKQQ-VWGA
LT-RLGSALSCGSLSNYKLPWVT---VSHHDPEVPFNHSFIEPPSAGWASDDSFSSDPES
-GAEDEGHTYSVPPREG-M-IPVAEAESPEASL-AGGPFP-----PPEDASTPFPIPRTS
SLARAKRPSVSFAEGTKFAPQSRRSSGELSSPIRKPKRFSRGSQPRPE-GQ--EAEESTS
PEQA----KTEE---APPEAVS--PGDADDA-----------------------------
-QDNSSSVATIYMLAGTPQK-----------SEGPSRSVFHCLGNFQRGQAE----S---
KVKSAIPKPIRRALGQNKGGPGLASG----------------------------------
-----STSQNPGSAPNISLGTRPE-----EV---SRELRDGT---KSAGRVQEVASGSFP
PIQDPQKQAE---EKRQEEPVYENVVHMSGPPQA--------

----------------------------TNPSPPAGLAAMGLRLL-PLLLLWTQGTRGSK
-----LDPNGQHVCMASSPSAELQCCPGWRQKDQECTIP-I

PF07974 // ENSGT00730000110380_4_Domain_0 (102, 132)

CEGLDACREDEVCVKPGLC
RCKPG-FFGAQ

ENSGT00730000110380_4_Linker_0_2 (132, 151)

CNSR--CPGQYWGPDCREI

PF00053 // ENSGT00730000110380_4_Domain_2 (151, 178)

CACHPHGQCEPATGVCHCQADRWGGRCEFA
CACG-PHGRCDPATGA-CRCESGWWSSTCRRPCQCNPA----------AARCDQTDGDCR
VP---------LIYWG-KRYTESQSCQTSEIAWI--GGLRKPGFWNGKCLMLWVLSIVPG
-----------DLS-----------ADPSICSLPSLPSCGHCKQKEPCSADTGSCESCEP
GWNGTQCHQPCPAGTFGESCRQLCPHCRLGEACQPDTGHCQRCDP--GWLG---------
------------------------------------PRCEDPCPPGTFGEGCSSACPTCV
QGTCDAVTGECVCNAGYWGPSCNTSCPSGFHGNNCSVPCECPEGPCNPVSGACQLG--PH
GQ-DAALIAGVLGPLLLLLLGIILCAC-CCWAARSDPKDRPA-RDGAAVSRVKLQ-VWGA
LS-SLGSALPCGSFSSHKLPWVT---VSHHDPEIPFNHSFIEPPSAGWASDDSFSSDPES
-GE-DESPAYCVPPQEG-M-VTVAHGEFPEASV-AGGPVP-----PPEDASTPFPIPRTS
SLARAKRPSVSFAEGTKFAPQSRRSSGEISSPLRKPKRLSRGAQLGPE-SQ--EAEESTG
SEKA----EMDE---TLPGAAS--PRDSATGRRRLPLGGRTVAERVEAIE--------GS
VLEGSGSVTTIYMLAGTPQS-----------SEGPVRSVLRRFGSFQKGQAE----P---
KVKSAIPKPPRRALSRNKGI-----------------------------PGLASGSASQS
PSLS-PSDELTRPLES--AGTGPE-----EV---ARGLGIGT---KSSGRAQELAPEGGP
QEQDPQKLAD---EEGQEEPQYENVVPISGSPAP--------

----------------------------NHPSPPAALAAMALGLLLPLLLLWTRGAQGSK
-----LDPNGQHVCMASSPSAELQCCPGWRQKDQECTTP-ICEGPDACQKDEVCVKPGLC
RCKPG-FFGAQCSSR--CPGQYWGPDCRQSCACHPHGQCEPATGVCRCHADRWGGRCEFA
CACG-PHGRCDPGTGV-CRCEPGWWTPTCRRQ

PF00053 // ENSGT00730000110380_4_Domain_4 (213, 261)

CQCHPA----------AARCDPATGACL
CQ---------AGWWG-RRCSFRCACNGSPCAQESGRCACRAGWWGRECGQQCQCVRGRC
HAASGQCACPPGFRGARCELP----CPAGTYGPQCKDSCGHCKQNEPCSPDTGTCESCEP
GWNGTQCHQPCPHGTFGDSCRQQCPHCRLGVTCQPDTGHCQHCDP--GRLG---------
------------------------------------PRCEDPCPPGTFGESCGSTCPTCI
QGTCHPVTGECACHAGYWGPSCNTSCPSGFHGVNCSFPCQCPEGPCHPVSGACQLG--PH
RQ-DAALVAGIVVPLL-LLLGIVCCAC-CCWATRLDPKEGPV-RDGAAVSRMKLQ-VWGA
LT-SLGSALPCGSLSSHKLPWVT---VSHHDPEIPFNHSFIEPPSAGWASDDSFSSDPES
-GEEDEGPAYCVPPQEG-M-VSVAQVESPEASA-AGGPFP-----APEDTSTPFAIPRTS
SLARAKRPSVSFAEGTKFAPQSRRGSGELSSPLRKPKRLSRVAQPGPE-GQ--EDEKPTG
PEPT----ETDE---APPGAAS--PRDPATGRHRLPLGGRTVAEHVEAIE--------SS
VQESSSPVTTIYMLAGTPRG-----------SEGPVQSVLRRFGSFQKGLAE----P---
KVKSAIPKPPRRALSRNKGS-----------------------------PGPASGSASPS
PGPA-LSEELTRGLES--VGTGPE-----DV---APGLGDGT---ESPGRAQEPARGGGP
PEPDPQKQAE---EEGQEEPQYENVTPISGPPEP--------

---------------------------------------MGLGLVFSLLLFWTREIQGST
-----LDPAGQHVCIGSSPS-ELQCCSGWRQKDQECTIP-ICEGPDACKKDEVCVKPGL

PF12661 // ENSGT00730000110380_4_Domain_1 (120, 132)

C
RCKPG-FFGAH

ENSGT00730000110380_4_Linker_1_2 (132, 151)

CSSR--CPGQYWGPDCRET

PF00053 // ENSGT00730000110380_4_Domain_2 (151, 178)

CPCHPRGQCEPATGVCQCQPNYWGKLCEFP
CTCG-PHGKCDPKTGL-CHCDPGWWSPTCRRP

PF00053 // ENSGT00730000110380_4_Domain_4 (213, 261)

CQCNP-----------LARCDQVTGACI
CP---------TGWWG-HRC

ENSGT00730000110380_4_Linker_4_5 (261, 307)

SFSCNCHTSPCLQDSGRCTCLQGWWGPECSRRCQCVRGQC
SVTSGH

PF12661 // ENSGT00730000110380_4_Domain_5 (307, 318)

CSCPPGFQGALCELP----CKPGRYGAQCKESCGHCEPNATCSPVTGNCESCKP
GWNGTQCKQPCPPGTFGERCTGKCPRCRLEEPCQVETGHCQRCDP--GWLG---------
------------------------------------HRCEKPCPLGTFGKGCSSTCPACV
QGTCNAVTGECVCSAGYWGTSCNSSCPSGFHGNNCSMPCQCPEGLCHPESGACQLG--PH
G--KNALIVGILVPLLLLLMGIICCVY-CCSASRLDPKDR--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------

---------------------------------------MGLELLLPLLLLWTQETQESE
-----LDPKGQNVCRGSSPLAKLVCCPGWKQKDGDCTVP-VCEGLDACRKDEVCVKPGFC
RCKPG-FFGAQCSSS--CPDQYWGPDCRET

PF00053 // ENSGT00730000110380_4_Domain_2 (151, 178)

CACYPHGKCDPATGVCQCHAGRWGDNCESQ
CSCG-PHGHCNPKTGQ-CRCDPGWWSATCRRQ

PF00053 // ENSGT00730000110380_4_Domain_4 (213, 261)

CQCNP-----------AARCDPDTGNCL
CP---------LGMWG-RRCNFRCHCHNSPCAPDTGRCMCQAGWLEPDCKRPCG------
------------------------------------------CHNAPCSVDTGSCESCEP
GWNGTRCQQPCSPGTFGENCSQQCPHCRDGEPCQIETGDCEHCDP--GRLGPSPQFRSVG
A-----------------------RPACPPTSESCSPRCEDTCPSGTFGEGCSSPCPTCV
QGACDAVSGECVCSAGYWGTSCNSSCLSGSYGNNCSLPCQCSDGLCDPVSGACLWG--RK
---KSLLIGSILGPLLLLLLGIACCAY-CHCATSREPKDRPA-RGGTALSRMKQQ-FWGA
LS-SLGSVLPCGSLSGYKLPWTV---WHVEKKVG--------RP----------------
-----GCSQALLSPLPG-M-VPVAPAELSPRES-SEATFP-----PPEDASTPFPIPRTS
SLARAKRPSVSFAEGTKFVSQSGRSSGELHSPARKPKRLSRGAQPGPE-GR--ETEESTS
LEQA----KMDK---APTAA--ARSGNSAN-GHQAPCGSQKVAKPGETTE--------GS
MQESSDSAASIYMLVGMPEK-----------SKGPVRSVLRRLGNFQKGQEE----P---
KVKSAIPKPPRRALGQKKGS-----------------------------SGMVSGSASQR
------------AVEP--VGVKPE-----EV---SRGLGDGR---ESPGRPQEPISSSSL
PEQDPQKHVE---EEEQEEPLYENVHTSGWPES---------

MAARPSGLVSSGKALGGSREGVGSCGGQTGLNPPAAPAAMGPRLLFPLLLLWTWGTRGSE
-----LDPNGLHVCVASSPSAELQCCPGWRQKDQECTIP-ICEGLDACGQDEVCVKPGLC
RCKPG-FFGAQCNSR--CPGQYWGPDCRET

PF00053 // ENSGT00730000110380_4_Domain_2 (151, 178)

CTCHPHGQCEPATGVCRCQPDRWGSRCEFP
CACG-PHGRCDPETGA-CHCEPGWWSSTCRRP

PF00053 // ENSGT00730000110380_4_Domain_4 (213, 261)

CQCNPA----------AARCDPATGSCL
CE---------PGWWG-RRCSFRCPCHGSPCAQESGRCACRPGWWGPECRQPCECVRGRC
SAASGQCICPPGFRGARCELP----CAPGRYGPQCRDSCGHCKQNEPCSADTGRCESCEP
GWNGTQCHQPCPPGTFGESCRQQCPHCRLGEACQPDTGHCQSCDP--GRLG---------
------------------------------------LRCEDPCPTGTFGEDCGSTCPTCV
QGACDAVTGECVCNTGYWGPSCNISCPSGFHGNNCSLPCECPEGTCHPVSGACQLG--SR
GQ-DAALIAGILVPLLLLLLAVACCAC-CCWAARLDPKDRPA-GDGTAMSRMKLQ-VWGA
LTSSLGSALPCASLSSHKLPWVT---VSHHDPEIPFNHSFIEPPSAGWVSDDSFSSDPES
-GE-EEGPAYCVPPQEG-M-VPVAQAESPEAGL-AGGAFP-----PPEDASTPFAIPRTS
SLARAKRPSVSFAEGTKFAPQSRRSSGELSSPLRKPKRLSRGGQLGPE-SQ--EPEEATG
PEQT----ETDG---APPGALG--SRDSAIGRHRLPLGGRTVAERVEAIE--------GS
VQQSAGSVTTIYMLAGTPRG-----------SEGPVRSVLRRFGSFQKGQAE----P---
RVKSAIPKPPRRALSRNKGS-----------------------------TGLASGSASPS
SGSA-PNEEVTRASAS--AGTGPE-----EV---AGGLGDGI---ESSGRGQELAPESGR
LDQGPQKPAD---EGSREEPQYENVAPISGPPEP--------

---------------------------------------MGPGLLFPLLLLGALGAPGSE
-----LDAGGRHVCKASSPSAELQCCPGWRQKDQECTIP-VCEGLDACREDEVCVKPGLC
RCKPG-FFGAQCNSR--CPGQYWGPDCREV

PF00053 // ENSGT00730000110380_4_Domain_2 (151, 178)

CACHPHGQCEPATGVCHCQPDRWGDRCESP
CACG-PHGRCNPETGA-CRCDPGWWSPTCRRP

PF00053 // ENSGT00730000110380_4_Domain_4 (213, 261)

CQCNPA----------AARCDQATGSCL
CE---------PGWWG-RRCSFRCACHGSPCAQESGRCACRPGWWGPECRQPCECVRGRC
GAASGQCTCPPGFRGVRCELP----CPAGRYGLQCRDSCGQCKQNKPCSADTGSCEACEP
GWNGTQCHQPCPPGTFGENCRQQCPHCRLGEACQPDTGHCQHCEP--GWRG---------
------------------------------------PRCEDPCLIGTFGEACGSTCPTCI
QGTCDTVTGECVCNAGYWGPSCNTSCPSGFHGNNCSVPCECPEGSCDPVSGACQLG--SH
SQ-DAALIAGILVPLLLLLLAIACCAC-CCWAARLDPKDRPV-RDGTAMSRMKLQ-VWEA
LTSSLGSALPCGSLSSHKLPWVT---VSHHDPEIPFNHSFIEPPSAGWASDDSFSSDSES
-GEEDEGPAYCVPPQEG-M-VSAAPAESSEASL-AGGPFP-----PPEDASTPFAIPRTS
SLARAKRPSVSFAEGTKFAPQSRRGSGELSSPLRKPKRLSRGTQPGPE-SQ--EIEEPTG
PQV-----ETDG---APPGTAS--PRDSAAGRRRLPLGGRTVAERVEAIE--------GS
VQESSGSVSTIYMLAGTPRG-----------PEGPVRSVLRRFGSFQRGQAE----P---
KVKSAIPKPPRRALSRNRGS-----------------------------PRLDSGSAHQS
PSSA-MKEELTGALES--AGTGSE-----EG---ARSLGGGI---KSSGGGQEVAPEDGP
LGQDPQKVAD---EEGQEEPQYENVVPISGPPDP--------

----------------------------TDPSPPAALAAMGPGLLFPLLLLEALGAPGSE
-----LDAGGRHVCKASSPSAELQCCPGWRRKDRECTIP-ICEGLDACREDEVCVKPGLC
RCKPG-FFGAQCNSR--CPGQYWGPDCREV

PF00053 // ENSGT00730000110380_4_Domain_2 (151, 178)

CACHPHGQCEPATGVCHCQPDRWGDRCEFP
CACG-PHGRCNPETGA-CRCEPGWWSPTCRRP

PF00053 // ENSGT00730000110380_4_Domain_4 (213, 264)

CQCNPA----------AARCDQATGSCL
CE---------PGWWG-RRCSFRCACHGSPCAQESGRCACRPGWWGPECRQPCECVRGRC
SAVSGQCSCPPGFQGVRCELP----CPAGQYGLRCRDSCGHCKQNKPCSADTGSCEACKP
GWNGTQCHQPCPPGTFGENCSQQCPHCRLGEACQPDTGHCQRCEP--GWRG---------
------------------------------------PRCEDPCLIGTFGEGCGSTCPTCV
QGACDAVTGECVCNAGYWGPSCNTSCPSGFHGNNCSVPCECPEGNCDPVSGACQLG--SH
SQ-DAALIAGILVPLLLLLLAIACCAC-CCWAARLDPKDRPV-RDGTAMSRMKLR-VWGA
LTSSLGSALPCGPLSSHKLPWVT---VSHHDPEIPFNHSFIEPPSAGWASDDSFSSDSES
-GEEDEGPAYCVPPQEG-M-VPAVPAESSEASL-AGGPFP-----PPEDASTPFAIPRTS
SLARAKRPSVSFAEGTKFAPQSRRGSGELSSPLRKPKRLSRGTQPGPE-SQ--ETEESTG
PQV-----ETDG---APPGTAS--PRDSAVGRRRLPLGGRTVAERVEAIE--------GS
VQESSGSVTTIYMLAGTPRG-----------PEGPVRSVLRRFGSFQKGQAE----P---
KVKSAIPKPPRRALSRNKDS-----------------------------PRLDSGSANQS
PSSA-MKEELTGALES--SGTGSE-----EG---ARSLGGSI---KSSEGGQELAPEDGS
LVQDPQKVAD---KEGQEEPQYENVVPISGPLEP--------

------------------------------------MAPTLTPALFPLLLLWTQGTQGST
-----LDPAGQHVCRGDSPS-ELQCCPGWRQKDRECTIP-ICEGPDACRKDEVCVKPGLC
RCKPG-FFGAQCSSR--CPGQYWGPDCRET

PF00053 // ENSGT00730000110380_4_Domain_2 (151, 178)

CPCHPNGQCEPYTGVCQCKPNYWGGRCEFP
CNCG-PHGRCDPKTGA-CHCDAGWWSSACNRP

PF00053 // ENSGT00730000110380_4_Domain_4 (213, 261)

CQCNP-----------VARCNQDNGACL
CP---------PGWWG-RRCSFKCRCHNSPCNQDSGYCSCLQGWWGPECNQRCQCVRGQC
SVTSGHCSCPPGFHGARCELP----CSPGRYGEQCRESCGHCKPNATCSPVTGNCESCKP
GWNGTQCKQPCPPGTFGERCQEQCPRCSLGEPCDAETGYCRRCDP--GWLG---------
------------------------------------HRCENRCPLGSFGEGCSSVCPDCV
QGTCDAVTGECVCSAGYWGTSCNSSCPSGFHGNNCSIPCQCPEGLCHPVSGACQLG--RH
G--KNALIAGILVPLLLLLLGIIGCVY-CYSANRLDPKDRPE-RTGAPLFRMKQQ-VWGA
LT-SLGSALSCGSLSNYKLPWVT---VSHHDPEVPFNHSFIEPPSAGWASDDSFSSDPDS
-GEEDEGHANFMPPREE-M-VSVAPKESPTASL-PGGPFP-----APEDASTPFPIPRTS
SLARAKRPSVSFAEGTKFTSQNGRGSGDLSSPIRKPKRLSRGAQSRPE-GQ--EAEELAG
LEQA----NTEE---DAPTATS--PREATTSHHQLPPSNQTVADCVETTS--------SS
IQEGSGSVATIYMLAGSPQK-----------PEGSVWSVIRRLGNNQKDQKA----P---
KVKSAIAKPLRRSPGRNLGSPGSGSA----------------------------------
-----PDAMLSG--TIEYTKVRPE-----EA---SRGPGDGT---ESLETVQEPVSENSS
LGQGSQRQAK---EKEPEEPLYENVALRSVPPKH--------

-----------------------------------AEAALGRKKVFPVHLLTQSSWGHA-
----RWDSGQQPFKGQHRFPAGPGCCPGWKQDGRACTVA-VCEGEDACREGEVCVKPGLC
RCPPG-FFGADCSSR--CPEQYWGHDCKRS

PF00053 // ENSGT00730000110380_4_Domain_2 (151, 178)

CPCHPNGRCDPVSGHCTCDPNHWGGLCQFP
CQCG-PHGRCDPLTGSCCHCEPGWWAPSCRKQ

PF00053 // ENSGT00730000110380_4_Domain_4 (213, 261)

CQCSPS----------TSHCDPLSGLCR
CL---------PGWWG-RRCSFKCSCNVSPCAQETGKCECLAGYWGPACQRRCDCGHGSC
SPVTGHCTCEPGYQGRSCRDP----CPAGKYGSQCVHSCGSCKRSQPCSPVDGFCLACQP
GWNGTLCKDPCAPGFHGEGCLQPCPRCQHGEPCDPQTGLCLRCDP--GWTG---------
------------------------------------PSCNSSCPVGTFGDGCQFLCPECV
SGSCDPVTGVCVCQAGYWGDSCNDTCPEGYFGVNCSSPCQCSRGTCDPAQGDCVLS--LK
--DHGALAAAILVPLLLLL--LCVACC-CCGAGSADARDRAAVPDDDVVARMKHH-VQGV
LA-NLSALVPCFNLGASKLPKVT---VSHHDMEIPYNPSFIEPPSSAWVSDSSFS-SFDT
---DNEGPEYSVPPREGI--PLLGGAELQDGASRPGEALPDPSAFDSEDVSQPFAIPRTS
SIAKAKRPSVSFAEGTKFGA------AETPSPSRKPKAPWGPSRLTPPPGDAAA--EPPG
ERPASDCYENPEPLSKGDESHRPSPRATPGGRRRVVSSTRHVAQRVEALEAAAKSGSWEA
KGKE-PDVTTIYMVVGTAGEDTK----AEGTGEGPVQAVLKRLGSLQKGKWAAKEEPKVR
RSMEAIQKPPRRALAQRRDSENS-------------------------------------
------------------------------------------------------------
------------------------------------------

-------------------------------------------------LLATGS---DL
PFRAGLLP--TDPVLPHSPLAELLCCPGWRQKDQECTIP-ICEGPDACRKDEVCVKPGLC
RCKPG-FFGARCSTP--CPDQYWGPDCREP

PF00053 // ENSGT00730000110380_4_Domain_2 (151, 179)

CSCHPHGKCDPVTGVCQCQANRWGNNCEHQ
CSCG-THGRCDPKTGL-CRCDSGWWSETCHRR

PF00053 // ENSGT00730000110380_4_Domain_4 (213, 261)

CRCNP-----------LAQCDEITGTCL
CA---------RGWWG-ERC

ENSGT00730000110380_4_Linker_4_5 (261, 293)

NFKCSCHTSPCAPDTGRCVCLPGWWGLDCKRP

PF00053 // ENSGT00730000110380_4_Domain_5 (293, 334)

CSCIHGSC
HSTSGQCTCMLGFQGTNCD----QPCTPGYYGMRCLQRCGHCKENAPCSKDLGHCESCEP
GWNGTLCQVSCSPGTFGESCSQQCPRCRGGKPCHAETGHCEHCDP--GRMGP--------
-------------------------------------RCEDSCPAGTFGEDCSSICPTCV
QGACDSETGECVCSAGYWGTSCNSSCLPGFYGSNCSLPCQCSDGFCNPISGACPLG--KV
EG-GA------LLPSMIYILG----------------HAGPA-RGGTTLSRMKQQ-VCGA
LS-SLGSALTCGSLSGYKLPWVT---VSHHDPEVPFNHSFIEQPSAGWASEDSFSSDSES
-GAENEDSAYCVSSPKG-T-VPVA-----QAES-SEATFP-----PPEDASTPFPIPRTS
SLARAKRPSVSFAEGTKFVSQSCRSSGELPSPIRKPKRLSRGAQAGPE-SQ--ETEESTS
TEQA----QVDK---APPAA--ATPSNSAN-GQRFPRGSQKAAEHGETTE--------DN
VQKSSDSVATIYMLAGMPER-----------SEGSVLSVFRRLGNFQKGQAE----A---
NVKSAIPKPPRRALARKKGS-----------------------------PGPAP------
-------NASLGAVES--IGVRQE-----EV---SRVLGDGS---ESPGRTQEPVSRNSL
PEHAPQKHVE---EEGPEEPLYENVPS---------------

------------------------------------------------------------
----DLDPKGVNVCISESVTKELVCCPGWKQEGRA

PF07974 // ENSGT00730000110380_4_Domain_0 (96, 132)

CTVV-IYKXEDTCKTDEVCIRPGVC
RCKPG-YFGASCNSR--CPDQYWGSDCKQSCSCFPNGKCDPVSGQCTCYSNRWGPNCQHP
CHCS-QHGACNPLTGV-CHCENGWWTPYCNKQ

PF00053 // ENSGT00730000110380_4_Domain_4 (213, 260)

CHCNLQ----------TSRCSQATGQCI
CD---------TGWWG-QKCSVKCNCNNSPCLQINGRCKCQEGWWGVSCEYQCDCLHGKC
SPLNGKCDCHVGYQGASCADP----CTPGTYGTNCKNRCGHCKQGQICSPVDGLCLSCDP
GWNGTHCDQPCPSGYHGENCGQRCPKCRGTEECNRETGTCEHCDA--GKLG---------
------------------------------------PRCDSKCPPGSYGERCQYLCPVCI
YGTCDPKTGECICDAGFWKQSCNETCPRGYYGLNCSSTCDCNGGPCSPIYGTCQWT--SS
--QKGALVAGVLVSVLFFL--FILCCCCCCGTDQSDSKNRVS-QEGGTFSRMKHN-FQGT
LA-NISSLLPCCSVGSTKLSWVT---VSHHDAELPFNHSFIESPSTGWLSENSFS-SFES
---DEGGPVYCVPPREGKC-PIVQGTSLQEISSKC-NVFPDSLAFNTDDVSQPFSIPRTS
SIAKAKRPSVSFAEGTKFGSR-RSSATETPNLVRKPKLALSLPKLPSIHSQSINREDLTH
SEEGNDFYEK-VCINQGPEDHPKVHRNVPVGRRRTMSNAQKVALKSE-------------
------------VSVGPPKKVYKPRRRSEGNIDGAVQAVLKRLGSFQKGIP---------
-------KPARKNLHQ--------------------------------------------
------------------------------------------------------------
------------------------------------------

---------------------------------------VGLGRLLPRFLLWLWVQGSA-
---QELDPNGRNVCKVGSPAVNLACCPGWKQEGRECTAA-L

PF07974 // ENSGT00730000110380_4_Domain_0 (102, 132)

CEGEDACGPREVCVRPGLC
RCKPG-FFGADCSSP--CPAQYWGHDCKRLCLCHPGGTCEAESGRCTCNPERWGELCQFR
CPC--PHGRCDPTTGA-CRCEQGWWGPDCKRQ

PF00053 // ENSGT00730000110380_4_Domain_4 (213, 260)

CQCNLA----------TSRCDPLTGHCH
CR---------LGWWG-RK

ENSGT00730000110380_4_Linker_4_5 (260, 293)

CRFKCSCNLSPCVQETGNCKCKAGFWGSACQWH

PF07974 // ENSGT00730000110380_4_Domain_5 (293, 318)

CDCLHGSC
NPLNGHCSCEPGFQGRSCQDP----CPAGMYGSQCVHSCGNCKHNQPCSSVDGFCLECQP
GWNGTLCKERCMPGFHGQGCLQPCPHCRQGDICDAETGSCPRCEP--GWTG---------
------------------------------------PSCNSSCPAGTFGDGCQLLCPECV
WGSCDPVSGDCLCQAGYWGASCNDTCPEGFFGVNCSSPCQCSRGTCHPAQGNCILNTGVT
--DHAALAAAILIPLLLLL--LCVVCC-CCGAGPADARDRAAVPDDDVVARMKHH-VHVV
LA-NISAMMPCFALNNSKLPKVT---VSHHDAEIPFNPSFIESPSAAWASDSSFS-SFDT
---DNEGPEYSVPPREG--------AELQAGMPPPSEALPDPTAFSSEDVSQPFTIPRTS
SIAKAKRPSVSFAEGTKFST------AETPSPGRKPKAMWGPSKLSLQSGDVGT--EISA
EQAASDGYESPDPLSKGDESHRPSPRATPGGRRRMITNTRHVAQRVEALEAAAKRGSWDG
KRK-EPNVTTIYMTVGTAGQDPK----AEGGVEGPVQAVLKRLGSLQRGRWAAKEEPMVR
RSMEGIQKPPRRALAQRRDS----------------------------------------
------------------------------------------------------------
------------------------------------------

---------------------------------------MGLGLLLPLLLLWTRGTQGSE
-----LDPNGQHVCVASSPSAELQCCAGWRQKDQECTIP-ICEGPDACQKDEVCVKPGLC
RCKPG-FFGAYCSSR--CPGQYWGPDCREN

PF00053 // ENSGT00730000110380_4_Domain_2 (151, 178)

CPCHPHGQCEPATGACQCQAHRWGAHC

ENSGT00730000110380_4_Linker_2_3 (178, 181)

EFP

PF00053 // ENSGT00730000110380_4_Domain_3 (181, 211)

CTCG-PHGRCDPVTGV-CRCEPGWWSPTCH

ENSGT00730000110380_4_Linker_3_4 (211, 213)

RP

PF00053 // ENSGT00730000110380_4_Domain_4 (213, 261)

CQCKPE----------AARCEQATGACV
CK---------PGWWG-RRCSFRCTCHGSPCDQDSGRCACRPGWWGPECRQQCECVRGRC
SAASGQCTCPPGFRGARCELP----CPAGSHGVQCAHSCGHCKHNEPCSPDTGSCESCEP
GWNGTQCQQPCLPGTFGESCGQQCSHCRRGEVCQPDTGHCQRCDP--GWLG---------
------------------------------------PRCEDPCPTGTFGEDCGSTCPTCV
QGACDAVTGECVCSAGYWGPSCNTSCPAGFHGNNCSVPCECPEGPCHPVSGSCQPG--SR
SR-DATLIASSLVPLLLLFLGLACCAC-CCWATRSDLKDRPA-RDRATVSRMKMQ-VWGT
LT-SLGSTLPCGSLSSHKLPWVT---VSHHDPEVPFNHSFIEPPSAGWASDDSFSSDPES
-AEADEVPAYCVPPHEG-M-VPVAQAESSEASL-AGGAFP-----PPEDASTPFAIPRTS
SLARAKRPSVSFAEGTKFAPQSRRGSGELSSPLRKPKRLSRGAQSGPE-GR--EAEESTG
LEEA----ETDE---ALPAAAS--PGDSATGHRRPPLGGRTVAEHVEAIE--------GS
VQESSGPVTTVYMLVGTPRG-----------SEGPVRSVFRHFGGFQKGQAE----P---
KVKRAIPKPPRQALNRKKGS-----------------------------PGLASGSVSQS
PNSA-PKAGLPGATGP--MAVRPE-----EV---AQGLGAGT---ESSGRAQEPISGAGF
PKQDPQKQAE---EERQEEPEYENVVPISRPPEP--------

---------------------------------------MGLGLLLPLLLLCSRGAQGSE
-----LDPKGQHVCMASSPSAELQCCPGWRQKDQECTIP-VCEGPDTCREDEVCVKPGLC
RCKPG-FFGAQCSSR--CPGQYWGPDCRES

PF00053 // ENSGT00730000110380_4_Domain_2 (151, 178)

CPCHPHGQCEPATGVCQCQADRWGSRCEFA
CLCG-PHGRCDPATGA-CRCEPGWWSSTCRRP

PF00053 // ENSGT00730000110380_4_Domain_4 (213, 261)

CQCNPA----------AARCDPATGACL
CE---------PGWWG-RRCSFRCACNGSPCAQESGRCACRPGWWGPECRQQCECARGRC
SAASGQCACPAGFRRCSIHP---------------PPVCGHCKQNEPCSPDTGRCASCEP
GWNGTQCHQPCPPGTFGESCRQQCPRCWLGEACQPDTGHCQRCDP--GWLG---------
------------------------------------PRCEDPCPTGTFGEGCGSPCPTCV
QGACDAVTGDCVCSAGYWGSSCNISCPSGFYGNNCSVPCECPEASCHPVSGACQLG--KV
EGGYAALIAGILVPLLLLLLGLACCAC-CCWAARSDLKDRPV-RDGTAVSRMKLQ-VCGA
LA-SLGSALPCSSLSTHKLPWVT---VSHHDPEIPFNHSFIEPPSAGWASDDSFSSDPES
-GEEDEGPAYCVPPQEG-M-VPEAQAASSEASL-TGGPFP-----PPEDTSTPFAIPRTS
SLARAKRPSVSFAEGTKFAPQSRRSSGELSSPLRKPKRLSRGAQTGPE-GQ--EAEESMG
PEQA----ETDE---APPAAAS--PRDSATGRRCVPLGGRTVAERVEAIE--------GS
VQENPGSVTTIYMLAGTPRG-----------SEGPVRSVLRRFGSFQKGQAE----P---
KVKSAIPKPPRRALSRNKGS-----------------------------PGLASGSPSQS
LHSA-PSAELTGAMES--TGVRPE-----EA---ARGLGTGI---ESSGRAQELVSGGGL
PEQDPQKQAE---EEGQEEPQYENVVPISGPPEP--------

---------------------------------------MGLRLLLPLLLLWPQGTRGSQ
-----LDPSGQHVCVASSPSAELQCCAGWRQKDQECSIP-ICEGPDACQEDEVCVKPGLC
RCKPG-FFGAHCSSR--CPGQYWGPDCRES

PF00053 // ENSGT00730000110380_4_Domain_2 (151, 178)

CPCHPHGQCEPATGACQCQADRWGARCEFA
CACG-PHGRCDPATGV-CHCEPGWWSSTCRRP

PF00053 // ENSGT00730000110380_4_Domain_4 (213, 264)

CQCNPA----------AARCDQATGACV
CQ---------PGWWG-RRCSFRCACHGSPCEQDLGRCACRPGWWGPNCRQQCQCERGQC
SPASGQCTCPPGFRGARCELP----CQAGSYGVQCGLSCGHCKHDEPCSPDTGSCESCQP
GWNGTQCQQPCPPGTFGESCGQQCPHCRHGDACQPDTGHCQHCDP--GWLR---------
------------------------------------PRCDDPCPMGTFGEDCGSACPTCV
QGACDAVTGECVCSAGYWGPSCNASCPAGFYGNNCSVPCECPEGLCHPVSGSCQPG--SL
GH-AAALLAGILVPLLLLFLGLACCACCCCWTARSDLKDRPA-RDGTTVSRMKLQ-VWGT
LT-SLRSSLPCGSLGAHKLPWVT---VSHHDPDLPFNHSFIEPPSAGWASDDSFSSDSEP
-AEADEAPAYCVPPQEG-M-VPEAQAQSLEASL-AGGVFP-----PPEDASTPFAIPRTS
SLARAKRPSVSFAEGTKFAPQTRRSSGELSSPLRKPKRLSRGAQAGPE-GQ--EAEESTG
PEEA----EAGE---SLPTAAS--PGDSATSHRRPPLGGLTVAEHVEAIE--------GS
VQEASGPVTTIYVLAGTPQG-----------SEGPVRSVLRHFGGFQKGQTE----P---
KVKRAIPKPPRQALNRKKGS-----------------------------PGVAS--VSQS
PSSP-PNARLPGATGSQAPAAKPE-----EV---AQGLGAGT---ESSGGTQEPVSGGGS
PEQDPQKQAE---EERQEEPEYENVMPIPRLPEP--------

---------------------------------------MGLGLLLPLLLLWTRGTQGSE
-----LDPNGQHVCVASSPSAELQCCAGWRQKDQECTIP-ICEGPDACQKDEVCVKPGLC
RCKPG-FFGAYCSSR--CPGQYWGPDCREN

PF00053 // ENSGT00730000110380_4_Domain_2 (151, 178)

CPCHPHGQCEPATGACQCQAHRWGAHCEFP
CTCG-PHGRCDPATGV-CRCEPGWWSPTCRRP

PF00053 // ENSGT00730000110380_4_Domain_4 (213, 261)

CQCNPE----------AARCEQATGACV
CK---------PGWWG-RRCSFRCTCHGSPCDQDSGRCACRPGWWGPECRQQCECVRGRC
SAASGQCTCPPGFRGARCELP----CPAGSHGVQCAHSCGHCKHDEPCSPDTGSCESCEP
GWNGTQCQQPCLPGTFGESCGQQCSHCRRGEVCQPDTGHCQRCDP--GWLG---------
------------------------------------PRCEDPCPTGTFGEDCSSTCPTCV
QGACDAVTGECVCSAGYWGPSCNTSCPAGFHGNNCSVPCECPEGPCHPVSGSCQPG--SR
SR-DATLIASSLVPLLLLFLGLACCAC-CCWATRSDLKDRPA-RDRATVSRMKMQ-VWGT
LT-SLGSTLPCGSLSSHKLPWVT---VSHHDPEVPFNHSFIEPPSAGWASDDSFSSDPES
-AEADEVPAYCVPPHEG-M-VPVAQAESSEASL-AGGAFP-----PPEDASTPFAIPRTS
SLARAKRPSVSFAEGTKFAPQSRRGSGELSSPLRKPKRLSRRAQSGPE-GR--EAEEFTG
LEEA----ETDE---SLPAAAS--PGDSATGHRRPPLGGRTVAEHVEAIE--------GS
VQESSGPVTTVYMLVGTPRG-----------SEGPVRSVFRHFGGFQKGQAE----P---
KVKRAIPKPPRQALNRKKGS-----------------------------PGLASGSVSQS
PNSA-PKAGLPGATGP--MAVRPE-----EV---ARGLGAGT---ESSGRAQEPISGAGF
PKQDPQKQAE---EERQEEPEYENVVPISRPPEP--------

------------------------------------------------------------
---------------------------------------------------EV-CVPGLC
RCKPG-FFGARCNSR--CPGQYWGPDCRES

PF00053 // ENSGT00730000110380_4_Domain_2 (151, 178)

CACHPHGQCEPATGVCHCQSDRWGDRCEFP
CACG-PHGRCNPETGA-CRCEPGWWSPTCRRP

PF00053 // ENSGT00730000110380_4_Domain_4 (213, 260)

CQCNPV----------AARCDQATGSCL
CE---------PGWWG-RRCSFRCACHGSPCAQESGRCACRPGWWGSECRQPCECVRGRC
SAASGLCTCPPGFRGARCELP----CPAGRYGLQCRDSCGHCKQNEPCSADTGSCESCKP
GWNGTQCHEPCPPGTFGESCRQQCPHCRLGEACQPDTGHCRHCDP--GWLG---------
------------------------------------PRCEDPCPIGTFGEGCGSTCPTCV
RGACDAVTGECACNAGYWGPSCNTSCPSGFHGNNCSVPCECPEGNCHPVSGACQLG--SH
GQ-DAALLAGILVPLLLLLLAIACCAC-CCWAARLDPKDRPA-RDGTAMSRMKLQ-VWGA
LTSSLGSALPCGSLSSHKLPWVT---VSHHDPEIPFNHSFIEAPSAGWASDDSFSTDPES
-GEEDEGPAYCVPPQEG-M-VPVAQAESPEASL-TGGPFP-----PAEDASTPFAIPRTS
SLARAKRPSVSFAEGTKFAPQSCRGSGELSSPLRKPKRLSRGGQPGPE-SQ--EAEESTG
PEQA----EMNG---APPGAAS--P-DSATGRRRLPLSGRTVAEREAIE---------GS
VQESAGSV-TIYMLAT-PRG-----------SED--VGVLRR------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------

-----------------------------------PLAAMGPGMMVPLLLLWTRGSQEST
-----LDPTGQHVCRGGSPS-ELQCCPGWRQKDQECSIP-VCEGPDACRKDEVCVKPGLC
RCKPG-FFGAQCSSP--CPGQYWGHDCRET

PF00053 // ENSGT00730000110380_4_Domain_2 (151, 178)

CPCHPRGKCEPATGVCHCQPTYWGTLCEFP
CTCG-PHGQCDPKTGV-CHCDPGWWSSTCLRP

PF00053 // ENSGT00730000110380_4_Domain_4 (213, 261)

CQCKP-----------VARCDQATGACL
CP---------SGWWG-RRCGFRCNCHTSPCRQDSGDCICLKGWWGPECSRRCQCVRGQC
SVSSGHCSCPPGFHGARCELP----CDPGHYGAQCRESCGHCAPNATCSPVTGNCESCKP
GWNGTQCKQPCPPGTFGERCGEQCPRCWLGEPCHAETGHCQRCDP--GWLG---------
------------------------------------DRCENPCPSGSFGEGCSSTCPACV
QGTCDAVTGECVCSAGYWGTNCNSSCPSGFHGNNCSIPCQCPEGLCHPVSGACQLG--HH
G--KNALIAGILVPLLLVLLGVICCAY-CCSAKRLAPKDRPE-RNGAALFRMKQQ-VWDT
LT-SLGAALPCGSLSNYKLPWVT---VSHHDPEVPFNHSFIEPPSAGWASDDSFSSDPDS
-GEEDESHAYSVPPREK-M-VPVAQEESPAASL-PGGPFP-----PPEDTSTPFPIPRTS
SLARAKRPSVSFAEGTKFAPQNGRSSGDLSSPIRKPKRLSRGAQPRPE-GQ--EAGEPAG
PEQA----NAEE---DAATATS--PGDAATSHHQLPPTNQTVAGCVETSN--------GS
IQESSGSVATIYMLAGTPQK-----------PEGPVWSVLRRLGNYQKDQAM----P---
KVKSAIPKPVRRALGRNQGST--GSA----------------------------------
-----PDAMLSG--TIKPTEVRPE-----EA---SRGLGDGT---ESLGTAQEPISGNSS
LEQGSQKQAE---EKEQEEPLYENVVPLSVPLQH--------

---------------------------------------MGLELLLPLLLLWTQKTQESE
LDPEGLDPEGQNVCKSSSPLAELLCCPGWRQKDQECTIP-ICEGPDACRKDEVCVKPGLC
RCKPG-FFGAQCSSP--CPDQYWGPDCREI

PF00053 // ENSGT00730000110380_4_Domain_2 (151, 180)

CSCHPHGKCDPVTGVCRCQADRWGSNCEFQ
CSCG-THGRCDPKTGL-CHCDPGWWSDTCRRRCRC--------------------TGTCL
CP---------SGWWG-ERCNFRCSCHKSPCTPDTGRCKCLPGWWGTDCRQPCSCIYGSR
HGTSGQCICKLGFQGTNCD----LPCTPGYYGLHCFQRCGHCKQSAPCSKDLGFCESCEP
GWNGTLCQVPCSPGTFGETCSQQCPHCRGGEPCQVETGHCEHCDP--GRMGP--------
-------------------------------------RCEDSCPVGTFGEDCSSICPTCV
QGACDPQTGECVCSAGYWGTSCNSSCLPGFYGNNCSLPCQCSDGLCSPVSGACHWG--HL
SK-EVALIAGSLVLLLLLLLGIAC----YCWATRLDPKDRPS-RGGTTLSRMKQR-VCGA
LS-SLGSALLCGSLSGYKLPWVT---VSHHDPEVPFNHSFIEQPSAGWASEDSFSSDSES
-GAENEDSAYCVSSPKG-T-VPVA-----QAES-LEATFP-----PPEDASTPFPIPRTS
SLARAKRPSVSFAEGTKFVSQSCRSSGELSSPIRKPKRLSRGAQAGPE-SQ--ETEESTS
MEQA----QVDK---APPAA--ARLSNSAN-GHRFPLDNQRVAEHGETTK--------DN
VQKSSDSVATIYMLAGMPER-----------SEGPVWSVFRRLGNFQKGQAE----A---
KVKSAIPKPPRRALAQKGST------------------------------TPSPGSANQS
PG---LAPSLVGAAES--RGVRQE-----EV---SRVLGDGS---ENPGGTWEPVSRNSL
PEHAPQKQAE---EEGAEEPLYENVRVPG-------------

---------------------------------------MGLGLLLPLLLLWTRGTQGSE
-----LDPNGQHVCVASSPSAELQCCAGWRQKDQECTIP-ICEGPDACQKDEVCVKPGLC
RCKPG-FFGAYCSSR--CPGQYWGPDCREN

PF00053 // ENSGT00730000110380_4_Domain_2 (151, 178)

CPCHPHGQCEPATGACQCQAHRWGAHCEFP
CTCG-PHGRCDPATGV-CRCEPGWWSPTCHRP

PF00053 // ENSGT00730000110380_4_Domain_4 (213, 261)

CQCKPE----------AARCEQATGACV
CK---------PGWWG-RRCSFRCTCHGSPCDQDSGRCACRPGWWGPECRQQCECVRGRC
SAASGQCTCPPGFRGARCELP----CPAGSHGVQCAHSCGHCKHNEPCSPDTGSCESCEP
GWNGTQCQQPCLPGTFGESCGQQCSHCRRGEVCQPDTGHCQRCDP--GWLG---------
------------------------------------PRCEDPCPTGTFGEDCGSTCPTCV
QGACDAVTGECVCSAGYWGPSCNTSCPAGFHGNNCSVPCECPEGPCHPVSGSCQPG--SR
SR-DATLIASSLVPLLLLFLGLACCAC-CCWATRSDLKDRPA-RDRATVSRMKMQ-VWGT
LT-SLGSTLPCGSLSSHKLPWVT---VSHHDPEVPFNHSFIEPPSAGWASDDSFSSDPES
-AEADEVPAYCVPPHEG-M-VPVAQAESSEASL-AGGAFP-----PPEDASTPFAIPRTS
SLARAKRPSVSFAEGTKFAPQSRRGSGELSSPLRKPKRLSRGAQSGPE-GR--EAEESTG
LEEA----ETDE---ALPAAAS--PGDSATGHRRPPLGGRTVAEHVEAIE--------GS
VQESSGPVTTVYMLVGTPRE-----------SEGPVRSVFRHFGGFQKGQAE----P---
KVKRAIPKPPRQALNRKKGS-----------------------------PGLASGSVSQS
PNSA-PKAGLPGATGP--MAVRPE-----EV---ARGLGAGT---ESSGRAQEPVSGAGF
PKQDPQKQAE---EERQEEPEYENVVPISRPPEP--------

---------------------------------------MGLGLLLPLLLLWTQGTQGSK
-----LDPNGQHVCVASSPSAELQCCAGWRQKDQECTIP-ICEGPDACQKDEVCVKPGLC
RCKPG-FFGAHCSSR--CPGQYWGPDCRES

PF00053 // ENSGT00730000110380_4_Domain_2 (151, 178)

CPCHPHGQCEPSTGACQCQADRWGARCEFP
CACG-PHGRCDPATGV-CHCEPGWWSSTCRRP

PF00053 // ENSGT00730000110380_4_Domain_4 (213, 261)

CQCNPA----------AARCEQATGACM
CK---------PGWWG-RRCSFRCACHDSPCEQDSGRCACRPGWWGPECRQQCECVRGRC
SAASGECTCPPGFRGARCELP----CPAGSHGVRCAHSCGHCKHNEPCSPDTGSCESCEP
GWNGTQCQQPCLPGTFGESCEQRCPHCRHGEACEPDTGHCQRCDP--GWLG---------
------------------------------------PRCEDPCPAGTFGEDCGSTCPTCV
QGACDAVTGDCVCSAGYWGPSCNASCPAGFHGNNCSVPCECSEGHCHPISGSCQPG--SR
SR-DTALIVGSLVPLLLLFLGLACCAC-CCWATRSDLKDRPA-RDGATVSRMKLQ-VWGT
LT-SLGSTLPCRSFSSHKLPWVT---VSHHDPEVPFNHSFIEPPSAGWASDDSFSSDPES
-GEADEVPAYCVPPQEG-M-VPVAQAGSSEASL-AGGAFP-----PPEDASTPFAIPRTS
SLARAKRPSVSFAEGTKFAPQSRRSSGELSSPLRKPKRLSRGAQLGPE-GR--EAEESTG
PEEA----EAHE---SFPAAAS--PGDSATGHRRPPLGGRTVAEHVEAIE--------GS
VQESSGPVTTIYMLAGTPRG-----------SEGPARSVFRHFGSFQKGQAE----P---
KVKRAIPKPPRQALHRKKGS-----------------------------PGLASGSVSQS
PNSA-PKAGLPGATGP--MAVRPE-----EA---VQGLGAGT---ESSGRAQEPISGGGS
PEQDHQKPAE---EERQEEPEYENVVPISRPPEP--------

------------------------------------------LCLSLYLQLWLWVQGSA-
---QELDPDGRNVCKADSPPAGLACCPGWKQEGRECTAA-L

PF07974 // ENSGT00730000110380_4_Domain_0 (102, 132)

CEGEDACGPDEVCVRPGLC
RCKPG-FFGADCSSPRRLPGAVGGPDCKQRCPCHPGGTCEAASGRCTCHPDRWGELCQFP
CQCG-PHGRCEPL-------------PSCKKQ

PF00053 // ENSGT00730000110380_4_Domain_4 (213, 295)

CQCNAA----------NSHCDPLTGHCH
CL---------PGWWG-RRCSFKCSCNLSPCTQETGKCECKAGFWGLAASSAANCLHGSC
NPLSGHCSCVPGYQGRSCREP----CPAGKYGGGR----GGCQSLATPVPV---------
--------QLRELQAQGEGCPQPCPRCRHGDACDAETGSCLHCGTQVTWGG---------
------------------------------------GQGRDPHPRGHFPS----------
---------------FLLSSSCNDTCPEGYFGVNCSSPCQCSRGPCHPVRGDCALS---L
--DPGALAAAILVPLLLLL--LCVVCC-CCSAGPADARDRQKSPSTPASSSRPRP-----
-------------------------------------PGFRTAPSP--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------

---------------------------------------MGLGLLLPLLLLWTRGTQGSE
-----LDPKGQHVCVASSPSAELQCCAGWRQKDQECTIP-ICEGPDACQKDEVCVKPGLC
RCKPG-FFGAHCSSR--CPGQYWGPDCRES

PF00053 // ENSGT00730000110380_4_Domain_2 (151, 178)

CPCHPHGQCEPATGACQCQADRWGARCEFP
CACG-PHGRCDPATGV-CHCEPGWWSYTCRRP

PF00053 // ENSGT00730000110380_4_Domain_4 (213, 261)

CQCNTA----------AARCEQATGACV
CK---------PGWWG-RRCSFRCNCHGSPCEQDSGRCACRPGWWGPECQQQCECVRGRC
SAASGECTCPPGFRGARCELP----CPAGSHGVQCAHSCGHCKHNEPCSPDTGSCESCEP
GWNGTQCQQPCLPGTFGESCEQQCPHCRHGEACEPDTGHCQRCDP--GWLG---------
------------------------------------PRCEDPCPTGTFGEDCGSTCPTCV
QGSCDTVTGDCVCSAGYWGPSCNASCPAGFHGNNCSVPCECPEGLCHPVSGSCQPG--SG
SR-DTALIVGSLVPLLLLFLGLACCAC-CCWAPRSDLKDRPA-RDGATVSRMKLQ-VWGT
LT-SLGSTLPCRSLSSHKLPWVT---VSHHDPEVPFNHSFIEPPSAGWASDDSFSSDPES
-GEADEVPAYCVPPQEG-M-VPVVQAGSSEASL-AAGAFP-----PPEDASTPFAIPRTS
SLARAKRPSVSFAEGTKFAPQSRRSSGELSSPLRKPKRLSRGAQSGPE-GR--DAEESAG
PEEA----EAPE---SFPAAAS--PGDSATGHRRPPLGGRTVAEHVEAIE--------GS
VQESSGPVTTIYMLAGKPRG-----------SEGPVRSVFRHFGSFQKGQAE----A---
KVKRAIPKPPRQALNRKKGS-----------------------------PGLASGSVGQS
PNSA-PKAGLPGATGP--MAVRPE-----EA---VRGLGAGR---ESSRRAQEPISGCGS
PEQDPQKQAE---EERQEEPEYENVVPISRPPEP--------

---------------------------------------MGLGLLLPLLLLWTRGTQGSE
-----LDPNGQHVCVASSPSAELQCCAGWRQKDRECTIP-ICEGPDACQKDEVCVKPGLC
RCKPG-FFGAYCSSR--CPGQYWGPDCREN

PF00053 // ENSGT00730000110380_4_Domain_2 (151, 178)

CPCHPHGQCEPATGACQCQAHRWGAHCEFP
CTCG-PHGRCDPATGV-CRCEPGWWSPTCHRP

PF00053 // ENSGT00730000110380_4_Domain_4 (213, 261)

CQCKPE----------AARCEQATGACV
CK---------PGWWG-RRCSFRCTCHGSPCDQDSGRCACRPGWWGPECRQQCECVRGRC
SAASGQCTCPPGFRGARCELP----CPAGSHGVQCAHSCGHCKHNEPCSPDTGSCESCEP
GWNGTQCQQPCLPGTFGESCGQQCSHCRRGEVCQPDTGHCQRCDP--GWLG---------
------------------------------------PRCEDPCPTGTFGEDCGSTCPTCV
QGACDAVTGECVCSAGYWGPSCNTSCPAGFHGNNCSVPCECPEGPCHPVSGSCQPG--SR
SR-DATLIASSLVPLLLLFLGLACCAC-CCWATRSDLKDRPA-RDRATVSRMKMQ-VWGT
LT-SLGSTLPCGSLSSHKLPWVT---VSHHDPEVPFNHSFIEPPSAGWASDDSFSSDPES
-AEADEVPAYCVPPHEG-M-VPVAQAESSEASL-AGGAFP-----PPEDASTPFAIPRTS
SLARAKRPSVSFAEGTKFAPQSRRGSGELSSPLRKPKRLSRGAQSGPE-GR--EAEESTG
LEEA----ETDE---SLPAAAS--PGDSATGHRRPPLGGRTVAEHVEAIE--------GS
VQESSGPVTTVYMLVGTPRG-----------SEGPVRSVFRHFGGFQKGQAE----P---
KVKRAIPKPPRQALNRKKGS-----------------------------PGLASGSVSQS
PNSA-PKAGLPGATGP--MAVRPE-----EV---ARGLGAGT---ESSGRAQEPISGAGF
PKQDPQKQAE---EERQEEPEYENVVPISRPPEP--------

-----------------------------VRLTEATLTAMGPWLP-PLLLLWLQGVLGEL
----ELDPTGRHVCQDGSSPLKSVCCPGWRQEGRECTAP-ICEGPDACEEEEVCVKPGLC
RCKPG-FFGAQCSSR--CPGQYWGSDCRQNCPCHPNGQCDAVTGECTCNKDHWGGQCQFL
CPCG-LHGHCNPLTGA-CRCEPGWWTDSCRKA

PF00053 // ENSGT00730000110380_4_Domain_4 (213, 261)

CQCS----SY------SSGCDQLTGACQ
CK---------PGWWG-RRCSFRCTCHHSACNQNTGHCICRDGWWGPECQKRCTCQHGHC
NPTNGHCVCHPGYQGPLCEQA----CPAGRYGVQCLDSCGHCRQKEPCSPDTGTCLACEP
GWNGTRCNQLCPPGTYGDNCGQLCPQCRQGEACQPASGHCQHCDP--GRTG---------
------------------------------------PRCEEPCAPGTFGEACGSVCPPCV
EGTCDAVTGDCVCSAGYWGPSCNISCPFGFYGANCSSPCPCPEGPCHPASGTCELG--FQ
G--QGALLAGILVPLLLLLLGIVACVSCCCWAAQPDPKDRLA-RDGATVSRVKLQ-VRGA
LS-SLGSALPCGSLSNHKLPRVT---GR-----------------RGWGEGGASSGPDRA
-GAPCLALLTWLSPQSV---TPFTEEEFQETHQ-AGRPPS-----APDDASAPFAIPRTS
SLARAKRPSVSFAEGTKFGPQSSQGSAELASPSRKPKRLSRAAQPPAE-GQ--EAEGLEG
PERP----Q-------EPPSPAAAQGDLSGGPRRLPPGGRTVAQRVEAIE--------SG
GRGSPGPVTTIYMLAGTPGA-----------AAGPVRAVLRRFGSFQKGRAE----P---
KAKGSMPKPPRRALSRDKGTLGPPPAPS-----------------------P------AS
PR-----GPEP--SHT------------------AGGQGEGPGGPKSPADTA----GGA-
PGDG-----PHVLAEAEEEPQYENVQPGGPP-----------

---------------------------------------MGLRLLLPLLLLWPGGTPGSQ
-----LDPSGQHVCVASSPSAELQCCAGWRQKDQECSIP-ICEGPDACREDEVCVKPGLC
RCKPG-FFGAHCSSR--CPGQYWG------------------------------TRCEFQ

PF00053 // ENSGT00730000110380_4_Domain_3 (181, 210)

CACG-PQGRCDPATGV-CRCEPGWWSPTC

ENSGT00730000110380_4_Linker_3_4 (210, 213)

RRP

PF00053 // ENSGT00730000110380_4_Domain_4 (213, 261)

CQCNPA----------AAHCDQATGACV
CQ---------PGWWG-RRCSFRCACHGSPCEQNSGRCACRPGWWGPDCRQQCQCERGQC
SPTSGQCTCPPGFRGTRCQLP-----------------CGHCKHDEPCSPDTGSCESCQP
GWNGTQCQQPCPPGTFGESCGQQCPHCRHGEACQPDTGHCQHCNP--GWLR---------
------------------------------------PRCDDPCPAGTFGEDCGSACPTCV
QGACDAVTGECVCSAGYWGPSCNISCPAGFYGNNCSVPCECPEGLCHPVSGSCQQG--SL
RR-TAALLVGILVPLLLLFLGLACCACCCCWTARSDLKDRPA-GDGTTVSRMKLQ-VWGT
LT-SLSSSLPCGSLGPHKLPWVT---VSHHDPDLPFNHSFIEPPSAGWASDDSFSSDSES
-AEADEAPAYCVPPQEG-M-VPAAQVQSSEASL-AGGVFP-----PPEDTSTPFAIPRTS
SLARAKRPSVSFAEGTKFAPQTRRSSGELSSPLRKPKRLSRGARAGPE-GQ--EADESTG
PEEA----EAGE---SLPTAAS--PGDSATGHQQPPLGGLTVAEHVEAIE--------GG
VQEASGPVTTIYVLAGTPRG-----------SEGPVRSVLRHFGGFQKGQTE----P---
KVKRAIPKPPRQALNQKKGS-----------------------------PGMAS--VSQS
PSSP-PNARFPEAMGS--PAAKPE-----EV---AQGLGAGT---ESSGGTQEPVSGGGS
PEQDPQKQAE---EERQEEPEYENVMSIPRLPEL--------

-----------------------------------MLAAMGLELVFSLLLFWAQGTQGST
-----LDPAGQHVCKGSSPS-ELQCCPGWRQKDQECTIP-ICEGPDACRKEEVCVKPGLC
RCKPG-FFGAQCSSR--CPGQYWGHDCRET

PF00053 // ENSGT00730000110380_4_Domain_2 (151, 178)

CPCHPRGQCEPATGDCQCQPNYWGRLCEFP
CTCG-PHGQCDPKTGL-CHCDPGWWSPTCRRS

PF00053 // ENSGT00730000110380_4_Domain_4 (213, 261)

CQCNP-----------AARCDQATGACV
CP---------PGWWG-RRCSFSCNCHTSPCMQDSGRCVCLPGWWGPECSRKCQCVRGQC
SVTSGHCSCPPGFHGIRCELP----CNPGHYGAQCKESCGHCEPNATCSPVTGNCESCKP
GWNGTQCKQPCPAGTFGERCTGQCPRCRLGEPCQAETGHCQHCDP--GWLG---------
------------------------------------HRCENPCPLGTFGKGCSSTCPACV
QGTCDAVTGECVCSAGYWGTSCNSSCPSGFHGNNCSIPCQCPEGLCHPVSGTCQLG--RH
G--KNALIVGILVPLLLLLMGIVCCAY-CCSGTRLDPKDRPE-RNGAAFFRMKQQ-VWGA
LT-NLGSALPCGSLSNYKLPWVT---VSHHDPEVPFNHSFIEPPSAGWASDDSFSSDPDS
-GEEDEAHAYSVPPREG-K-VPMAQEESPEASL-PGGSFP-----PPEDASTPFPIPRTS
SLARAKRPSVSFAEGTKFAPQNGRSSGDLSSPIRKPKRLSRGAQPHPE-GQ--EAEESTG
PEQV----NTEE---DALTAAS--SGDPATSHGQLPPGSQTVAECAETTD--------GG
IQDSSGSVATIYMLAGTPQK-----------PEGPVWSVFRRLGNYQKDQAA----P---
KVKSAIPKPLRRSLGRNQAST--GSA----------------------------------
-----PDAVLSG--VMESTAVRPE-----ET---PRGLGDGI---ESSGTVQEPDAGGSS
-----QKQAE---EKEQEEPLYENVVPMSVLPQH--------

------------------------------------------------------------
------------------------------------------------------------
-----------------CPGKYWGPDCREN

PF00053 // ENSGT00730000110380_4_Domain_2 (151, 178)

CLCHPHGQCEAATGVCQCQPNYWGRLCESV
CSCG-PHGQCDQKTGL-CHCDPGWWSPTCRRP

PF00053 // ENSGT00730000110380_4_Domain_4 (213, 261)

CQCNR-----------AARCDQVTGACL
CP---------SGWWG-HRCSFKCSCHNSPCVQDSGKCTCLPGWWGPECTHRCQCVRGQC
SVTSGHCSCPPGFYGTRCELP----CDPGGQSS---------------------------
------------------------------------------CRQ--RGAR---------
------------------------------------NKCENPCPLGSFGEGCSSICPTCV
QGTCDAVTGECVCISSAGKDGPI-----SKMGPSK---------SLNMWPSPMFPG--QH
S--RNALMAGILVPLLLLLVGLICCVY-CCSATRLDPKDRPE-RNGAALFRMKQQ-VWGA
LT-NLGSSLPCGSLSNYKLPWVT---VSHHDPEVPFNHSFIEPPSAGWASDDSFSSDPDS
-GEEDENHTYSVPPREG-M-VSVAQEESPAASL-PGGPFP-----PPEDASTPFPIPRTS
SLARAKRPSVSFAEGTKFAPQNGRNSGDLSSPIRKPKRLSRGAQPRPE-GQ--EAEEPAG
PEQA----NTEE---DVPTTIS--PGDAATI-HQPPPTNRTVAECVETTN--------SS
IQESSGSVATIYMLAGTPQK-----------PEGPVLSVFRRLGNYQKDQAA----P---
KVKSAIPKPLRRSLGRNQGSPGSGSA----------------------------------
-----PEAMLSG--TIESTEVRPE-----EA---SRGLGDGT---ESLGTVQEPVSGNSS
LEQCSQKQVE---EKEQEEPLYENVVPMSVPPQH--------

MSVHPSGLVSSGKALGGSREGVGSCGSQINSSPPTLLAAMGLGLLFLLLLLWTAGIQGSE
-----LDPNGQHVCMGSSPSAELQCCPGWRQKDRECTIP-ICEGLDACQKDEICVKPGLC
RCKPG-FFGAQCSSR--CPSQYWGPDCRET

PF00053 // ENSGT00730000110380_4_Domain_2 (151, 178)

CPCHPHGQCDPATGKCQCQADRWGRRC

ENSGT00730000110380_4_Linker_2_3 (178, 181)

EFT

PF00053 // ENSGT00730000110380_4_Domain_3 (181, 211)

CACS-SHGRCDPETGV-CHCNRGWWSSTCR

ENSGT00730000110380_4_Linker_3_4 (211, 213)

RQ

PF00053 // ENSGT00730000110380_4_Domain_4 (213, 261)

CQCSS-----------TSQCDQSTGACL
CH---------SGWWG-RRCSFRCSCNGSPCEQLSGRCICQPGWWDSECRQKCQCVRGLC
SATSGQCSCPPGFHGARCELP----CAPGSYGVQCSKSCGQCEQNASCSPDTGHCESCKP
GWDGTQCQQPCSPGTFGKNCSQQCPHCRLGEACQPETGHCQHCDP--GWLG---------
------------------------------------PRCEDSCPMGTFGEGCGSTCPTCI
QGSCDAVTGECVCSAGYWGTSCNSSCPSGFHGNNCSIPCQCTEGLCHPVSGACPYS--K-
---DAILTAGILVPLLLLLLGIACWAY-YRWTTRLDLKDRPV-RDGAALSRMKQQ-VWGA
LT-SLGSALSCGSLSRHKLPWVT---VSHHDPEVPFNHSFIEPPSAGWASDDSFSSDPES
-GVEDEVPAYCVPPQQG-M-VPVTHAESAEASL-AGGPFP-----PPEDTSTPFAIPRTS
SLARAKRPSVSFAEGTKFASQSCRSSGELSSPFRKPKRLSRGAQPGPE-GQ--EAKESAT
LEQG----NTDE---AAPATVS--PGDSAIDHQY-YLEDQTAAECVEAID--------SG
VKETSDPVATIYMLAGTPQR-----------SEGPVLSIFRHFGNFWKGQAE----A---
KVKTAIPKPPRRVLGQNKNSPGLASSSASQRPGVIAKPPRRARGQNKGNPGLSSGSASQS
FGLA-PNAKLSCTMES--IGVRSE-----EV---SRGVGDGI---ESSGRAQEPVIGNSP
PEQDLQKQAE---EEGQEEPLYENVVLVSGPPES--------

-----------------------------------TLAAMGLGQLIPLLLLWIQGTHGSE
-----LDPGGQHVCTGSSPS-ELQCCPGWRQKDQECTIP-ICEGPDACGKDEVCVKPGLC
RCKPG-FFGAQCSSR--CPGQYWGPDCRES

PF00053 // ENSGT00730000110380_4_Domain_2 (151, 178)

CPCYPHGQCEPATGMCQCQPTHWGRLCEFP
CTCG-SHGHCDPKTGS-CHCDPGWWSSKCLRM

PF00053 // ENSGT00730000110380_4_Domain_4 (213, 261)

CQCNH-----------GARCDQATGTCL
CP---------VGWWG-RRCSFSCNCHKSPCMQETGRCTCLQGWWGSNCRQKCECERGQC
SVNSGQCSCPPGFHGTRCELP----CSPGRYGVQCTESCGHCKLNTTCSPVTGSCESCKP
GWNGTQCKQPCPPGTFGESCHEQCPHCRLGEPCHAETGHCQRCDP--GWLG---------
------------------------------------HRCENPCPLGTFGEDCRSICPTCV
QGTCDAVTGKCVCSAGYWGNSCNSSCPSGFHGNNCSIPCQCPEGLCHPVTGACQLG--HH
G--KTALITGILVPLLL-LLGITCCIY-CCWATQPNPKDRPE-RDGTALFRMKQQ-VWGA
LT-SLGSALPCGSLSNYKLPWVT---VSHHDPEVPFNHSFIEPPSAAWASDDSFSSDPDS
-GAEDESHAYFMPPREE-V-APVAQEESPEASL-TGGPFP-----PPEDASTPFPIPRTS
SLARAKRPSVSFAEGTKFAPQNGQNSEELSSPIRKPKRLSRGAQPRPE-GQ--EAEESTG
IEQA----NTED---NVPTATS--HREAATSHHQLPPGGPTLAECVETTD--------GR
IQEIPGSVATIYMLAGTPQR-----------SEGSVWSVFRRVGNFQKDQAE----P---
KVKSVIPKPLRRALGRNQGSS--GLA----------------------------------
-----LGATVPG--TMESTGVRPE-----EA---SRGLGDGI---ESLGVVLEPISGNSL
LEQGPWKQD------EEEEPLYENVIPMSAPPQH--------

------------------MPWLGSSRG--PAAPRLQTGMVQLLLLLFGLRFWPWIGSCA-
---QELDPSGRNVCKATSLSADLACCPGWKQEGRECTAA-LCEGEDACKVDEVCVRPGIC
RCKPG-FFGAHCSSR--CPDQYWGSDCRES

PF00053 // ENSGT00730000110380_4_Domain_2 (151, 178)

CACHPHGKCDPVSGQCSCNPSRWGELCQFP
CQCG-PHGLCNTLTGA-CHCEPGWWAPNCKKQ

PF00053 // ENSGT00730000110380_4_Domain_4 (213, 260)

CQCNLA----------GSLCDPVSGQCV
CA---------QGWWG-RRCRFRCDCHHSPCAQDSGRCECRAGFWGPLCQRHCDCLHGNC
NPHDGRCSCSPGYQGRSCGDP----CPAGYYGSQCSYSCGHCKRSQPCSPMDGFCLACEA
GWNGTRCDQQCPPGSHGENCAQVCPSCRKGEACNPETGACLSCDP--GKTG---------
------------------------------------SSCEAPCPAGTFGDGCRFPCPDCV
NGSCDPVSGECVCQAGYWGTSCNETCPEGFFGANCSSTCRCAGGLCHPHSGDCVLR--SR
--QQGALIAGTLIPLLLLL--LCITCCCCCGTSQLDARDRAAAADGDAVSRMKHH-VQGV
LA-NLSSLLPCLSLRGYKLPRVT---VSHHDTEIPFNPSFIEPPSAAWASDSSFSSSFDT
---DDEGPAYCVPTREDA--PAAAGFELQEGNSKC-PEFPDASAFNSEDVSQPFTIPRTS
SIARAKRPSVSFAEGTKFGPQCRSDSVETPTTTRKPKAPWGVTKLPSHQPQADPEEGPKQ
GGSPGDIYENPERTSEAEESHRPSPGGAPGGRRKAASSGRHVAQRVEALEAALNPNALEV
----KQNVTTIYVTVGTAGRASKPSESADGSREGPVQAVLKRLGSFQRAKRAFREDPPVR
KSTESIQKPPRRALGLGRDSRDVLPQPASPHKESCKTT----DPEPSEAPELRTGR----
-------------HQIEAPEKRQSLTPTSPLCKRLAPPGEGL--------TGDPKESDSP
EEARSQE--TNEQAAVEEEPKYENVSPNHGSPVTSPGCEAST