ENSGT00710000106295_4 : Linker Region Query Results

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEI-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RRGPPPP-PRSRGPPR--GLRG------GSGGAR---
-----------------GPPSRGGYMD-DGGYSMNFN---MS--------SSRGPLP---
----VKRGPP---PRSG-GPPPKRSTPS---------------------------GPVR S
S--SGMGG-RAPVSRGR--DSYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYAPP-
PR---DYTYRDYSHSS-SRDDYP-SRGYG------DRDGY--GRDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGPPP----SYGG--SSRYDDYSS-SRDG---------YGGSRDSYSS---
-SRSDLYSSGR-DRVGRQERGLPPSMERGYPPP-RD-----------------------S
YSSSSRGA-PRG--GGRGG------SRSDRG---------------GG--RSR------Y
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-----------------------------------

-------------------------------MVEADCPEKFF--------IGGLNMET-E
----KALEAPF------VEV-LLM----KDRETNKS-RGFAFVPFESPADAKDAARDMNG
NG--------------------RR--GLPPPPRTRGPSR--SLRGG---RGGSGGTR---
-----------------EPPSWGGHMD-DGGYSMHFN---MS--------SSREPLL---
----VKRGPP---PRSG-GPSPKRSAPP----------------------------KR--
SAPVHSSR-RAPLSRGR--D-----------------------NV-----YLSPRDDVSS
SR----------------------------------------------------------
------------------------------------------------------------
---------------------------------------------DYPSSCNTRDYAPP-
PG---DYTYRDYSHSS-SCDDYP-SRGY------SDRDGYDRD--HYYS-DHPSGSSYRD
S--YESYD----------------------------------------------------
------------------------------------------------------------
-NSHSAPPTQGPPPFY----AG--SSRYHDYSS-SRDG-----------------C----
GRSR---------DSYSSKRGLAPSIERGYSS-PCDS-----------------------
YSSSSCRA-PRG--GGRGGS-------------RSDRGGG---RSRY-------------
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-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNLETDE
----KALEAEFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKAAARDMNG
KSLDGKAI-KVAQATKPAFESSRRGPPP---PHSRGRPR--FLRGT---RGGGGGPR---
-----------------RSPSRGGPDD-DGGYAGDFD---LR--------PSRAPMP---
----MKRGPPP---PRRAGPPPKRAAPS---------------------------GPARS
S -GGGMRG-RALAVRGR--DGYSG--------PPRREPPPPRRVP-----YLGPRDEGYS
SRD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSRRDY---REPRGFAPS-
PR---EYTHREYGHSS-VRDDCP-LRGYG------DRDGYG-CRDRDYG-DHPSRGSYRE
P--FESYG----------------------------------------------------
------------------------------------------------------------
-DLRGGAPGRGTPPSYG---G---GGRYEEYRG-CSP--------DAYSGGRDSYSS--S
YGRSDRYSRGR-DRVGRPDRGLSLSMERGCPPQ-RDS-----------------------
YSRSGCRV-PRG--GGRLGG-------------RMERGGG---RSRY-------------
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-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNLETDE
----KALEAEFGKYGRIIEV-LLM----KDRETNKS-RSFAFVTFESPADAKAAARDMNG
KSLDGKAI-KVAQATKPAFESSRRGPPPPR---SRGRPT--FLRGT---HGGGGGPR---
-----------------GPPSRGGPDD-DGDYPGDFD---LR--------PSRAPMPMKR
G-----PPPP---PRRA-GPPPKRAAPS---------------------------GLARS
G-GGGMRG-RAPAARGR--DGYSG--------PPPREPPPPRRAP-----YLGPREEGYS
SRDG--------------------------------------------------------
-------------------------------------------------YS---------
-------------------------------------------SRDY---RDPRGFARS-
PR---EYSHRNYGYSS-VRDDCH-LRGY------GDRDGYGGRD-RDYG-DHLSGGSYRE
P--FKSYG----------------------------------------------------
------------------------------------------------------------
-DRRGAAPGRGTPPSY----GG--GGRYDEYRGCSPDA---------YSGGRDGYSS--S
YSRSDRYSWGR-DRVGRPDRGLPLSMERGCPP-QPDL-----------------------
TSYSASKC-EMNHPGHNFIR-------------AANHPGK---RSTITP------FCNPH
---------------SQKVCYTN-EENFMSHTT-----------------------YF--
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-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNRETNE
----KALEAVFGKYERIVEV-LLM----KDHETNKS-RGFAFVTFESPPDAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RRRPPPP-PRTRGLPR--GLRGG---RGGSGGTR---
-----------------GPPSRRGHM----------------------------------
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-----------------------------------

-------------------------------MVEADRPGKLF--------VGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETSKS-RGFAFITFESPADAKDAARDMNG
KLLDGKSI-KVEQATKPTFESGGRRGPPPP-PRSRGPPR--GLRGGG-RGGSGGGTR---
-----------------GPPSRGGHMD-DSGYSLNFN---MG--------SSRGPLP---
----VKRGPP---PRSGGGPPPKRSAPS---------------------------GPVR S
S--SGMGG-RAPVSRGR--DSYGG--------PPRRDPMPSRRDV-----YMSPRDDGYN
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYQSSRDNRDYAPP-
PR---DYAYRDYGHSS-SRDDYQ-SRGYS------DRDGY-GGRDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPARGPPP----SYGG--SSRYDDYS---RDG---------YGGSRESYSS---
-SRSDIYSSGRGDRVGRQDRGLPPSMDRGYPPP-RD-----------------------S
YSSSSRGA-PRG---GRGG------SRSDRG---------------GG--RSR------Y
------------------------------------------------------------
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-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEI-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RRGPPPP-PRSRGPPR--GLRG------GSGGTR---
-----------------GPPSRGGYMD-DGGYSMNFN---MS--------SSRGPLP---
----VKRGPP---PRSG-GPPPKRSTPS---------------------------GPVR S
S--SGMGG-RTPVSRGR--DSYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYAPP-
PR---DYTYRDYSHSS-SRDDYP-SRGYG------DRDGY--GRDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGPPP----SYGG--SSRYDDYSS-SRDG---------YGGSRDSYSS---
-SRSDLYSSGR-DRVGRQERGLPPSMERGYPPP-RD-----------------------S
YSSSSRGA-PRG--GGRGG------SRSDRG---------------GG--RSR------Y
------------------------------------------------------------
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-----------------------------------

-----------------------------MILVEADCPGKFF--------TGGLNMETNE
----KALEAPFGKHGRIV----------NSETTK----------------------QSFE
--------------------SG-RHGLPPP-PRIRGPPR--GLRGG---RGGSGGTR---
-----------------EPPSCGGHMD-DGGYSMHFN---MS--------SSRGSLP---
----VKRGPP---PR----------------------------------------KPVRS
S--SGMGG-RAPLSRGR--DSYGG--------PPRSEPLPFRRDV-----YLSPRDDVYS
AKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------NSSSRDSPSSCDTRDYAPP-
PR---DYTYRDYGHSS-SCDDYP-SRGCS------DRDGYD--RDHDYS-DDPSGSSYRD
S--YESYD----------------------------------------------------
------------------------------------------------------------
-HSHSGPPTQGPPPFY----TG--SSRYHDYSS-SRDG---------YGRSQDSYSS---
-SRSNLYSSGC-DRLGRQERGLPPSMERGYPSP-RDS-----------------------
YSTSSCRA-PRS--GGGGG------S-------RSDRGGG---RSRY-------------
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-----------------------------------

-------------------------------MVEADHPGKLF--------IGGLNRETNE
----KMLKAVFGKHGPISEV-LLI----KDR-TSKS-RGFAFITFENPADAKNAAKDMNG
TSLHGKAI-KVEQAKKPSFQSGGRRRPPAS-SRNRSPSG--SLRSA---RGSSGGTR---
----------------GWLPSHEGHLD-DGGYTPDLK---MS--------YSRGLIP---
----VKRGPS---SRSG-GPPPKKSAPS---------------------------AVAR-
S -NSWMGS-QGPMSQRR--ENYGV--------PPRRATISSWRNDRMS-----TRHDGYA
TNDGNHPSCQ-ETRDYAP---PSRGYAYRDNGHSNRDEHSSRGYRNHRSSRETRDYAPPS
RGHAYRDYGHSRRDESYSRGYRNHRSSRETREYAPPSRG--HGYRD---YGHSRRHESYS
RGYR-----------------------------------------NHPSSRETRDYAPP-
HR---DYAYRDYGHS--SWDEHS-SRGY------SYHDGYGEALGRDHS-EHLSGSSYRD
A--LQRYG----------------------------------------------------
------------------------------------------------------------
-TSHGAPPARGPRMSY----GG--STC-HAYSN-TRDR---------YGRSWESYS----
-SCGDFHYCDR-EHVCRKDQRNPPSLGRVLPDPR-EA-----------------------
YGSSSYVA-SIV---DGGES-------------RSEKGD----SSRY-------------
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-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNLETDE
----KALEAEFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKAAARDMNG
KSLDGKAI-KVAQATKPAFESSRRGPPP---PRSRGRPR--FLRGT---RGGGGGPR---
-----------------RSPSRGGPDD-DGGYAGDFD---LR--------PSRAPMP---
----MKRGPP----PRRVGPPPKRAAPS---------------------------GPARS
S -GGGMRG-RALAVRGR--DGYSG--------PPRREPLPPRRDP-----YLGPRDEGYS
SRD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------GYSSRDY---REPRGFAPS-
PG---EYTHRDYGHSS-VRDDCP-LRGYN------DRDGYG-GRDRDYG-DHLSRGSHRE
P--FESYG----------------------------------------------------
------------------------------------------------------------
-DLRGAAPGRGTPPSYG---G---GSRYEEYRG-YSP--------DAYSGGRDSYSS--S
YGRSDRYSRGR-HRVGRPDRGLSLSMERGCPPQ-RDS-----------------------
YSRSGCRV-PRG--GGRLGG-------------RLERGGG---RSRY-------------
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-----------------------------------

-------------------------------MVEADCPGKLV--------IGGLNTETNE
----KVLEAVFGKYGRIGKV-LLM----KDRETNKS-RGFAFVTCESPADAKDTASDMNG
KSLDGKAI-KVEQATKSSFESG-TCRPPPP-PRSRGPPR--GLRGGTGGRGGSGGTR---
-----------------VPPSHGGHMD-DGGYSMNFN---MS--------SSRGPLP---
----VKRGQL---QQRG-APHPKRSAPS---------------------------GPV--
-----LGG-RAPLSCGR--DSYG--------------------DV-----YFLPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRGYPISLDTRDYAPL-
PR---GYTYRDYGHCS-SRDDYP-LRGYS------DRDEY----------DHLSGGSY-L
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTQGPLPCY----GG--SSRYDDYSS-SQDR---------YGGSLD-------
------------------KRGLPPSIERGYPPP-CDS-----------------------
YSSSSHGA-PRG--LRSDC------YV--------------------RKVLFT------Q
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-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVF------VEV-LLM----KDQETSKS-RGFVFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RRGLPPP-PRSRGPPR--GLR----G--GSGGTR---
-----------------GPPSRGGHMD-DGGCSMNFN---MS--------SSRGPLP---
----VKRGPP---PRSG-GPPPKRSAPS---------------------------GPVL S
S--SGMGG-RAPVSHGR--DSYGG--------PPRREPLPSCRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------IYSSRDYPSSRDTRDYAPP-
PR---DYTYRDYGHSS-SRDDCP-SRGYS------DRDGY--S-DRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGRPP----SYGG--SSRYDDYSS-SRDG---------YGGSRDSYPS---
-SQSDLYPSGR-DRVGRQERGLPPSMEKGYPPP-RD-----------------------S
YSSSSHRA-PRG--GGHGG------SRSDRG---------------GG--RSR------Y
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-----------------------------------

------------------------------MIEADC-PAKFF------------------
-----------------------------IGETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RRGPPPP-PRSRGPPK--GLRGG---RGRSGGTR---
-----------------GPPSWRRHMD-D-------------------------------
----IKRGPP---PRSG-GPPPKRSAPS---------------------------GPVR S
S--SGMGG-RAPVSR-------CG--------PPGREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SSSSRDYPSSRDTRGYAPPP
PR---DCTYRDYGHFN-SRDDYP-SRGYS------DRDGYN--SDHDYS-DHPTGDSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSSSAPPTGGPPPPI------------LWWKR---------------------------
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-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGK-------------------------GFAFVTFESPVDAKDAAQDMNG
KSLNGKAI-KVEQATKPSFEGG-RLRPPPP-PRSRGPPR--GLRGG---RGGSGGNR---
-----------------GPPSYGGHMD-DGGYSMNFN---MS--------SSRGPLP---
----VKRGPP---PRSE-GPPPKRSAPS---------------------------GPVRS
S--SGMRG-RAPVSRGR--DSY--------------------RDV-----YLSPRDYGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYF-----------NYTPP-
PR---DYTYRDYGHSS-SRDDYP-SRGYS------DRDGYG--RDRDYS-DHPSGGSYRD
L--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRRPPPSYGGRSRY------------DDYSS-SRDG---------YGGSRDSYSS---
-SRSDLYSSGG-DRVGRQERGLPPSMERGYPPP-HDS-----------------------
YSSSSRGA-PRG--GGRGG------S-------RSDRGGG---RSRY-------------
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-----------------------------------

-------------------------------MMATDRPGKLL--------IGGLSAETTE
----KSLEAEFGKYGHIVEV-LLI----KDQNTNKS-RGFAFITFESPEDAKDAAKEMNG
KFLDGKTI-KVEQANKPSFESGGRQRLQPP-ARNRGHPR--NLRWE---RGRTGGAR---
-----------------GHVFRGGDFG-DNGYN--LN---MS--------SSGGPYP---
----VKRGPS---SRRE-GPSPKRSAPS---------------------------AQGR-
S -RSGMRG-RGPVL-RR--ENY--------RGGPHREPVSSRR-----DNYVSPRD----
------------------------------------------------------------
-----------------------------------------DGYATKDSYS---------
-------------------------------------------GRDYPSPRDTKDYAPP-
SR---EYAYHDYGHSS-SWDGHA-SRGH------SDRDGYGGNRDRDYF-EHRTGGSYRD
S--YKSYG----------------------------------------------------
------------------------------------------------------------
-GSHGALSGRGLPLSY----GR--RSRYDDYSS-TRDR---------YGGGQKSYS----
SSQGYTYLSSR-DRGGRQERGFPSLKDRVYPAP---------------------------
-------------------------------------------RESYSSSGCETSRGGHG
-----GSR---S-------ERVG-RNRY--------------------------------
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-----------------------------------

-------------------------------MAEADRPGKLF--------IGGLSPETDE
----KGLETTFGKYGRIIEV-LLM----KDRETAKS-RGFAFVTFESPADAKAAVRDLNG
KSLDGKAI-KVAQATKPAFESGRRGPLPPR---SRGRS----------------------
------------------------------------------------------------
------------------------------------------------------------
----------RALRGGG--DGYAG--------PARREP-PPRRDP-----YLGPREGGYS
PRDS--------------------------------------------------------
-------------------------------------------------YS---------
-------------------------------------------GRDYGAAREPRDFAAS-
PR---DYSYRDYGHAS-ARDDCP-SRGY------CDRDGYGGRD-RDYG-EHLSGGSYRD
N--FESYG----------------------------------------------------
------------------------------------------------------------
-DPRGAAPTRGPQPSY----GG---GRYDEYRGWSPDN---------YRDGYSGGS----
G-----GGRGE-RYSGGRDRGLPPPMERGYPP-ERES-----------------------
YSRSGRRA-PPR--GGRLGS-------------RAERGGV---RSRY-------------
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-----------------------------------

-------------------------------MAETDQPGKIF--------IGGLNIKTRQ
----KTLQEIFGRFGPVARV-ILM----RDRETKKS-RGFAFLTFRRLADAKNAVKEMNG
VILDGKRI-KVKQARRPSSLESGSKKR-PP-S-FSRTRG--ASRIL---KCGRGGRS---
--------------RARSGPSCEGNLG-GDRYTPNFN---VS--------SSGRHFA---
----VKRNPS---SKRD-DPPSKRSATS---------------------------AQTR-
S-NTGLRG-REPHR--R--EI--------SRNMPRGEPASSRR-----DEYPLPRD----
------------------------------------------------------------
-----------------------------------------YGQSSND------------
-----------------------------------------------------RKYES--
-T---SRGYCDYGNYH-SREESA-SKVF------SDHAGYLGGRDRDFS-EYLSGNSYRD
T--YRSYG----------------------------------------------------
------------------------------------------------------------
-RFHEAPSARG----------G--NNRYDDYSN-SQDG---------YGGRGEPYI----
SNRSNIYSSDY-ERSGRQEVLPPPIDREYFDREGRQE-----------------------
RGHSP-KD-GL-----YSAS-------------RESYSS----NTKIWG-----------
------------------------------IPWR--------------------------
--------SWRKQI----------------------------------------------
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-----------------------------------

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-------------------------MN-DGGYSTNFN---TS--------SSRVPLP---
----VKRRPP---PVSG-GPPPKRSAPS---------------------------GPVCS
S--SGMGG-RAPVSR-----------------PPQRGLLPSHRDL-----YLSPRNDGYS
TRD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSSDYPSSCDTRDYAPP-
PR---DYTYRDYGHSS-SR--------YS------NRDGYG--RDRDYS-DHPSGGSYRD
S--HESCG----------------------------------------------------
------------------------------------------------------------
-KSGSAPPTRGPPPSY----GG--SSHYDDYSS-SRDR---------YGGSRDSYSS---
-SRTDLYLSGH-DQADRQERELPPSMERGYPPP-HDS-----------------------
YSSSGHGT-PGG--GGREGR------------------GG---RNRY-------------
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-----------------------------------

--------------------------------VEADCPGKVF--------IGGLSTETSK
----KALEAVFGKYGRIVEA-LLR----KDYETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQAAKLSFESG-RGGLPPP-PRSRGPPR--GLRGG---RGGR-------
------------------EPSRGRHMD-DGGYSMNFN---MS--------SSRGPLP---
----IKGGPP---LRSG-SPPPKTSAPS---------------------------GPVR S
S--SGMGG-RAPVSRGR--DSYGD--------PPRREQLPSGRDV-----YLSPRDDEYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPS-----------
-------------------------SRYS------DRDGYS--CDC----------SYRD
S--HESYG----------------------------------------------------
------------------------------------------------------------
-NSGSAPPTRGPLCGY------------DDYSS-SPDR---------YGGSRDSYSS---
-SQSDLYSSGG-DRVGRQERGLPPSVEIFNVIP-TAIQAVDSRSLRNRHTAFHNG-----
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-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KAPEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RHGPPPP-PRSRGPPR--GLRGGR-G--GSGGTR---
-----------------GPPSRGGHMD-DGGYSMDFN---MT--------SSRGPLP---
----VKRGPP---PRSG-GP-PKRSAPS---------------------------GPVR S
S--SGMGG-RAPVSRGR--DSYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYAPP-
PR---DYTYRDYGHSS-SRDDYP-SRGYS------DRDGY--GRDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGPPP----SYGG--SSRYDDYSS-SRDG---------HGGSRDSYSS---
-SRRDLYSSGR-DRVGRQERGLPPSMERGYPPP-RD-----------------------S
YSSSSRGA-PKG--GGRGG----------RG---------------GG--RSR------Y
------------------------------------------------------------
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-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESS-RRGLPPP-PRSRGPPR--GLRGGR-G--GSGGTR---
-----------------GPPSRGGHMD-DGGYSMNFT---MS--------SSRGPLP---
----VKRGPPPPPPRSG-APPPKRSAPS---------------------------GPVR S
S--SGLGG-RAPVSRGR--DSYGG--------LPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDARDYAPP-
PR---DYTYRDYGHSS-SRDDYP-SRGYS------DRDGY--GRDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGPPP----SYGG--SSRYDDYSS-SRDG---------YGGSRDSYSS---
-SRSDLYSSGR-DRVGRQERGLPPSMERGYPPP-RD-----------------------S
YSSSSRGA-PRG--GGRGG------SRSDRG---------------GG--RSR------Y
------------------------------------------------------------
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-----------------------------------

-------------------------------MFEADHPGKLF--------FSGLNTETNE
----KTLEAVFGKYGRIVEV-LLM----KDPETNKS-GGFAFVTFE------DAARDMNG
KSLDGKAI-KVEQVTKLSFESG-RRGPPPP-PRSRGPPR--GLRGG---RRG--------
------------------------------------------------------------
----IKTGPP---PKNG-GPTPKRSALS---------------------------RPVSS
S--SGKGG-RAPV---------SG--------PLGKEPLPSSRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRHTRDYAPP-
PR---DYTYRDYGHSS-SRDDYL-SRGYS------DRDGYG--RDRDYS-DHPSGVSYRD
A--YETYG----------------------------------------------------
------------------------------------------------------------
-NSGSALPTRGPPPSY----GG--SSPYDDYSS-SQDG---------Y----DSHSS---
-SRSDLYSSGR-DRVGRQESGLHSSMERGYPPP-RDS-----------------------
YSSSSHGA-PRD--GGRRG------R------------GG---RSRY-------------
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-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIAEV-LLM----KDRETSKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RYGPPSP-PRSRGPPR--GLRGGR-G--GSGGTR---
-----------------GPPSQGGHMD-DSGYSMNFN---MS--------SSRGPLP---
----VKRGPA---PRSG-GPPPKRSAPS---------------------------GPVC S
S--SGMGG-RAPVSLGR--GSYGG--------PPRRELLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SHSSRDYPSSRDTRDYAPP-
PR---GYTYHDYGHSS-SRDDYP-SRGYS------NRDGY--GRDHDYS-DHPSGGSYRD
S--R--------------------------------------------------------
------------------------------------------------------------
-------------PLP--SYGG--SSHYDDYSS-SRD---------GYGGSQESYSS---
-SQSDLYSSGS-DQVGRQERGLPPSMERGYPPP-HD-----------------------S
HSSSSRGA-PRG--GGHGG------SRSDRG---------------GG--RSR------Y
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-----------------------------------

-------------------------------MVEANLPGKLF--------IGELNTETDA
----KVLEAVFGKYGRIIKG-HLM----KDRETNKS-RGF-----ESPADAKDAAREMNG
KSLDGKAI-KVEQATKPSFESG-RRGPPPP-PRS--------------------------
-----------------------RHMD-DGGYSMNFN---MS--------SSRGPLP---
----VKRGSP---LRSG-VLPPERSAPS---------------------------GPVR S
S--SGMGR-RAPVSCGR--DSYGG--------PPRREPLPPSRDV-----YLSPGDDGYP
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSIDYPNSRDTRDYAPP-
PR---DYTYRDYDGYG-RDGDYS-DH--------------P--RGG----------SYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRRPLPSYGESSGY------------DDYSS-SRDR---------HGGNRDSYSS---
-SRSDLYSSGW-ERVGRQERG------------------------------LPLLWKGGT
LLHVIPTA-PGG--GGRGGSRSDRGG----------------GRSRC-------------
------------------------------------------------------------
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-----------------------------------

-------------------------------MAETNQPGKIF--------IGGLNIKTRQ
----KTLQEIFGRFGPVARV-ILM----RDRETKKS-RGFAFLTFRRLADAKNAVKEMNG
VILDGKRI-KVKQARRPSSLESGSKKR-PP-S-FSRTRG--ASRIL---KCGRGGRS---
--------------RARSGPSCEGNLG-GDRYTPNFN---VS--------SSGRHFA---
----VKRNPS---SKRD-DPPSKRSATS---------------------------AQTR-
S-NTGLRG-REPHR--R--EI--------SRNMPRGEPASSRR-----DEYPLPRD----
------------------------------------------------------------
-----------------------------------------YGQSSND------------
-----------------------------------------------------RKYES--
-T---SRGYCDYGNYH-SREESA-SKVF------SDHAGYLGGRDRDFS-EYLSGNSYRD
T--YRSYG----------------------------------------------------
------------------------------------------------------------
-RFHEAPSARG----------G--NNRYDDYSN-SQDG---------YGGRGEPYI----
SNRSNIYSSDY-ERSGRQEVLPPPIDREYFDREGRQE-----------------------
RGHSP-KD-GL-----YSAS-------------RESYSS----NTKIWG-----------
------------------------------IPWR--------------------------
--------SWRKQI----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RRGPPPP-PRSRGPPR--GLRGGR-G--GSGGTR---
-----------------GPPSHGGHMD-DGGYSMNFN---MS--------SSRGPLP---
----VKRGPP---PRSG-GPPPKRSAPS---------------------------GPVR S
S--SGMGG-RAPVSRGR--DSYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYAPP-
PR---DYTYRDYGHSS-SRDDYP-SRGYS------DRDGY--GRDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGPPP----SYGG--SSRYDDYSS-SRDG---------YGGSRDSYSS---
-SRSDLYSSGR-DRVGRQERGLPPSMERGYPPP-RD-----------------------S
YSSSSRGA-PRG--GGRGG------SRSDRG---------------GG--RSR------Y
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVF------------------DCETNKS-RGFASVTFESPADAKDAARDMNG
KSLDGKA I-NVEQATKPSFESG-RRGPPPP-PRSRGPPR--GLQGGR-G--GSGGTR---
-----------------GPPSHGGHMD-DGGYSMNFN---MS--------SSRGPLP---
----VKRGPP---PRSG-GPPPKRSAPS---------------------------GPVR S
S--SGMGG-RAPVSCGR--DSYGG--------PPLREPLPSRRDI-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYAPP-
PR---DYTYHDYGHSS-SRDDYP-PRGYS------DRDGY--GRDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRGAPRG----PLL--SYGG--N----DYSS-SHD---------GYGGSRDSYSS---
-SQSDLYSSGR-DWVGRQERGLPPSMERGS------------------------------
----SHGA-PRG--GGRGG------SRSDRG---------------GG--RSR------Y
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RRGPPPP-PRSRGPPR--GLRGGR-G--GSGGTR---
-----------------GPPSRGGHMD-DGGYSMNFN---MS--------SSRGPLP---
----VKRGPP---PRSG-GPPPKRSAPS---------------------------GPVR S
S--SGMGG-RAPVSRGR--DSYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYAPP-
PR---DYTYRDYGHSS-SRDDYP-SRGYS------DRDGY--GRDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGPPP----SYGG--SSRYDDYSS-SRDG---------YGGSRDSYSS---
-SRSDLYSSGR-DRVGRQERGLPPSMERGYPPP-RD-----------------------S
YSSSSREA-PRG--GGRGG------SRSDRG---------------GG--RSR------Y
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNLETDE
----KALETAFGKYGRIIEV-LLM----KDRETSKS-RGFAFVTFENPADAKAAARDMNG
KSLDGKAI-KVAQATKPVFESGRRGPPP---PRSRGRPR--GLRGT---RG--GGPR---
-----------------RPPSRGGSAD-EGGYTGDFD---LR--------PSRAPMP---
----LKRGPP----PRRAGPPPKRAAPS---------------------------GPARS
--GAGIRG-RAAGSRGR--DGYGG--------PPRRELPPPRRDP-----YLGPRDEGYS
PRE---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSARDPRDFAPS-
PR---DYTYRDYGHSS-ARDECP-SRGYC------ERDGYG-GRERDYG-EHPSGGSYRD
P--FDSYG----------------------------------------------------
------------------------------------------------------------
-DPRGAGPARGPPPSYG---G----GRYEEYRG-CSP--------DGYGG-RDSY-----
--RSERYSSGR-ERVGRPERGLPPSVERSCPTP-RDS-----------------------
YSRSGRRAPPRG--GGRVGS-------------RLERGGG---RSRY-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADHPGKLF--------IGGINTETNE
----KALEAVFGKYGRIVEV------------------GFAFVTFESP-DVKDAARDMNG
KSLDGKTI-KALTAPPPQSK----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

--------------------------------MDAGCPDKLF--------VGGLNQETNE
----KNLKAAFGSFGPIIDV-VLI----KNLETKQS-RGFAFVTFERSADAKTALKDMNG
KVTMF-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADHPGKLF--------IGGLNRETNE
----KMLKAVFGKHGPISEV-LLI----KDR-TSKS-RGFAFITFENPADAKNAAKDMNG
KSLDGKAI-KVEQAKKPSFQSDGRRRPPAS-SRNRSPSE--SLRSA---RRNSGGTR---
----------------GWLPSHEGHLD-DGGYTPDLN---MS--------YSRGLTP---
----VKRGPS---SRSG-GPPPKKSAPS---------------------------AVAR-
S -SSWMGS-QGPMSQRR--ENYGV--------PPRRGTISSWRNDRMS-----PRYDGYA
TNDGNHPSCQ-ETRDYAP---PSRGYAYRDNGHSNRDEHSSRGYRNHRSSRETRDYAPPS
RGHAYRDCGHSHRHETYSRGYRNHRSSRETRDYPPPSRG--HAYRD---YGHSRRHESYS
RGYR-----------------------------------------NSPSSRETRDYTPP-
PR---DYAYCDYGHS--SWDEHS-SRGY------SYHDGYGEALGRDHS-EHLSGSSYRD
A--FQGYG----------------------------------------------------
------------------------------------------------------------
-TSHDAPPARGPRMSY----GG--STC-HAYSN-TRDR---------YGRSWESYS----
RSCGDFHYCDR-EHVCRKDQRNPPSLGRVLPDPR-EA-----------------------
YGSSLYVA-SIV---DGGES-------------RSEKGD----SSRY-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

------------------------------------------------------------
-----------------MEV-LLM----KDRETNKS-RRFAFVTFESPADDKDAAPDMNG
KSLGGKAI-KVVQATKPSFESG-RRGPPPP-PRSRGPPR--GLRKR------SGGTR---
-----------------GPPSYGGHMD-DGGYSMNSN---IS--------SSSGPFP---
----VKRGPP---PRSG-GPPPKRSAPS---------------------------GPVHS
Y--SGMGG-RAPVSRGR--DSYGG--------PPQKEPL-----------CLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRNTRDYVPP-
PR---DYTYLDYGHSS-SFADYP-SRGYS------DRDGYG--WDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NLSCAPPTRGRP-----------------------------------------------
---SDLYSSGR-DWVGRRERGPPPSMERGYPPP-RDS-----------------------
YSCSSRGA-PRG--GGRGG------S-------RSDRGGG---RSRY-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------IVEAGRPGKLF--------TGGLHTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESSADAKDAARDMNG
KSLDGKAI-K VEQAPKPTFESG-RRGPPPP-PRSTGPPR--GLRGGR-G--GSRGTR---
-----------------GPPSRGGHMD-HGGYSMNFN---MS--------SSRGPLP---
----VKKGPP---PRSG-GPPPKRSAPS---------------------------GPVR S
R--SGMGG-RAPVSRGR--DSSGG--------LPRREPLPSPRDV-----YLSPRDDRCS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSCDTRDDAPP-
PR---DYTYRDYGHSS-SRDDYP-SRGYS------DRDGY--GRDRDYS-DHPSGGSYRE
S--SESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGPPP----SHGG--SSRYDDYSS-SRDG---------YGGSRDSYSS---
-SRSDLYSSGR-DRVGRQERGLPPSMERGYPPP-RD-----------------------S
YSSSSHRA-PRC--GGRGG------RRSDRG---------------GG--RSR------Y
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

--------------------------------VEADRPGKVF--------VGGLSTETNK
----KALEAVFGKYGRIVEA-LLR----KDHETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RRGLPPP-PRSRGPPR--GLRGG---RGGR-------
------------------EPSRGRHMD-DGGYSMNFN---MS--------SSRGPLP---
----VKRGSP---LRSG-SPPPKTSAPS---------------------------GPVH S
S--SGMGG-RAPVSRGR--DSYGD--------PPRREQLPSGRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYPSRDYPSSRDTRDYAPP-
PR---DYTYCDYGHFG-SHGDYP-SRGYS------DRDGYS--RDC----------SYRD
S--HESYG----------------------------------------------------
------------------------------------------------------------
-NSGSAPPTRGLPCGY------------DDYSS-SPDR---------Y----DSYSS---
-SQSDLYSSGG-DQVGRQERGSSRGALRGGGHG-GS--QSDRGGGRSR---Y--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MFEADHPGKLF--------FSGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDPETNKS-GGFAFVTFE------DAARDMNG
KSLHGKAI-KVEQVTKPSFESG-RRGPPPP-PRSRGPPR--GLRGG---RRG--------
------------------------------------------------------------
----IKTGPL---PKNG-GATPKRSALS---------------------------RPVSS
S--SGKGG-RAPV---------SG--------PLGREPLPSSRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYAPP-
PR---DYTYRDYGHSS-----------YS------DRDGYG--RDRDYS-DHPSGVSYRD
A--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSALPTRGPPPSY----GG--SSPYDDYSS-SRDG---------Y----DSHSS---
-SRSDLYSSGR-DRVGRQESGLHSSMERGYPPP-RDS-----------------------
YSSSSRGA-PRD--GGRGG------R------------GG---RSRY-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEI-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RRGPPPP-PRSRGPPR--GLRG------GSGGTR---
-----------------GPPSRGGYMD-DGGYSMNFN---MS--------SSRGPLP---
----VKRGPP---PRSG-GPPPKRSTPS---------------------------GPVR S
S--SGMGG-RTPVSRGR--DSYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYAPP-
PR---DYTYRDYSHSS-SRDDYP-SRGYG------DRDGY--GRDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGPPP----SYGG--SSRYDDYSS-SRDG---------YGGSRDSYSS---
-SRSDLYSSGR-DRVGRQERGLPPSMERGYPPP-RD-----------------------S
YSSSSRGA-PRG--GGRGG------SRSDRG---------------GG--RSR------Y
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MAEADRPGKLF--------IGGLSPETDE
----KGLESTFGKYGRIIEV-LLM----KDRETGKS-RGFAFVTFESPADAKAAVRDLNG
KSLDGKAI-KVAQATKPAFESGRRGPA---------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------PRRDA-----YLGPREGGYS
PRES--------------------------------------------------------
-------------------------------------------------YS---------
-------------------------------------------GRDYAGARDPRDFAAS-
PR---DYSYRDYGHAS-ARDDCP-SRGY------CDRDSYGARE-RDYG-DHLSGGSYRD
A--FESYG----------------------------------------------------
------------------------------------------------------------
-DPRSAAPPRGPQPSY----GG---GRYDEYRAC---------------------G----
S-----GGRGE-RYSGGRERGLPPPLERGYPP-TRDS-----------------------
YSRSGRRV-PPR--GGRLGS-------------RSERGGI---RSRY-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEI-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RRGPPPP-PRSRGPPR--GLRG------GSGGTR---
-----------------GPPSRGGYMD-DGGYSMNFN---MS--------SSRGPLP---
----VKRGPP---PRSG-GPPPKRSTPS---------------------------GPVR S
S--SGMGG-RAPVSRGR--DSYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYAPP-
PR---DYTYRDYSHSS-SRDDYP-SRGYG------DRDGY--GRDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPSTRGLPP----FYGG--SSRYDDYSS-SRDG---------YGGSRDSYSS---
-SRSDLYSSGR-DRVGRQERGLPPSMERGYPPP-RD-----------------------S
YSSSSRGA-PRG--GGRGG------SRSDRG---------------GG--RSR------Y
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MAETDQPGKIF--------IGGLNIKTRQ
----KTLQEIFGRFGPVARV-ILM----RDRETKKS-RGFAFLTFRRPADAKNAVKEMNG
VILDGKRI-KVKQARRPSSLESGSKKR-PP-S-FSRTRG--ASRIL---KCGRGGRS---
--------------RARSGPSCEGNLG-GDRYTPNFN---VS--------SSGRHFA---
----VKRNPS---SKRD-GPPSKRSATS---------------------------AQTR-
S-NTGLRG-REPHR--R--EI--------SRNMPRGEPASSRR-----DEYPLPRD----
------------------------------------------------------------
-----------------------------------------YGQSSND------------
-----------------------------------------------------RKYES--
-T---SRGYCDYGNYH-SREESA-SKVF------SDHAGYLGGRDRDFS-EYLSGNSYRD
T--YRSYG----------------------------------------------------
------------------------------------------------------------
-RFHEAPSARG----------G--NNRYDDYSN-SQDG---------YGGRGEPYI----
SNRSNIYSSDY-ERSGRQEVLPPPIDREYFDREGRQE-----------------------
RGHSP-KD-GL-----YSAS-------------RESYSS----NTKIWG-----------
------------------------------IPWR--------------------------
--------SWRKQI----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

------------------------------MILEADRPGKVF--------VGRLSTETNK
----KALEAVFGKYGRIVEA-LLR----KDHETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RRGLPPP-PRSRGPPR--GLRGG---RGGR-------
------------------EPSRGRHMD-DGGYSMNFN---MS--------SSRGPLP---
----VKRGSP---LRSG-SPPPKTSAPS---------------------------GPVR S
S--SGMGG-RAPVSRGR--DSYGD--------PPRREQLPSGRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYPSRDYPSSCDTRDYAPP-
PR---DYTYCDYGHFS-SHGDYP-SRGYS------DRDGYS--RDC----------SYRD
S--HESYG----------------------------------------------------
------------------------------------------------------------
-NSGSAPPTRGPPPSY------------GEAVA-MMIT---------AAHLTDMVEV---
-ET---VIQAA-KVIST--------------QV-VVIKLADKKEG------FTLLWKSST
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

------------------------------------------------------------
------------MVEADLEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFEGG-RRGPPPP-PRSRGPPR--GLRSG---RGGSGGTR---
-----------------GPPS---HVD-DDGYSMDFN---MS--------SSRGPLQ---
------------------------SAPS---------------------------GPVH R
S--SGMGR-RAPVSRGR--DSYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSFCDTRNYAPP-
PR---DYTYRDYGHSS-TRDDYP-SRGNS------DRDGYG--RDCNYS-DHPSGCSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGPLPFY----GG--SSRYDDYSS-SRDG---------YGGSRDSYSS---
-S----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEI-LLM----KDRETNKS-RGFAFVTFESPADAKDVARDMNG
KSLDGKAI-KVEQATKPSFESG-RRGPPPP-PRSRGPPR--GLRG------GSGGTR---
-----------------GPPSRGGYMD-DGGYSMNFN---MS--------SSRGPLP---
----VKRGPP---PRSG-GPPPKRSTPS---------------------------GPVR S
S--SGMGG-RMPVSRGR--DSYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYLSSRDTRDYAPP-
PR---DYTYRDYSHSS-SRDDYP-SRGYG------DRDGY--GRDREYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSCSAPPTRGPPP----SYGG--SSRYDDYSS-SRDG---------YGGSRDSYSS---
-SRSDLYSSDR-DRVGRQERGLPPSMERGYPPP-RD-----------------------F
YSSSSRGA-PRG--GGRGG------SRSDRG---------------GG--RSR------F
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-K VEQATKPSFETG-RHGPPPP-PRSRSPPR--GLRGG---RGGR-------
------------------S-------------------------------SSRGPFP---
----VKRGPP---PRSG-GPPAKRSAPS---------------------------GPVR S
S--SGMGG-RAPVSRGR--DSYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYASP-
PR---DYTYCDYGHSS-SRDDYP-SRGYS------DRDGYG--RDR----------DYPD
H--PSGGF----------------------------------------------------
------------------------------------------------------------
-HRNSYDRHKGPHHLM------------VEAVA-MMIT---------AAHVTDMVEV---
-ETVTQ---AA-EV--------------TSTQV-VVIGLADKKEG------FPLLWKGGT
LLHVIPTA-VQA--AEHPGVVAVEEANLIEGEAEADIKNKTLDQNPCSKKR---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEVDCPGKLY--------IGGLNRETNE
----KMLKAVFVKHGPISEV-LLI----KDR-TSKS-RGFAFITFENPADAKNAAKDMNG
KSLDGKAI-KVEQAKKPSFQSGGRRRPPPS-SRNRSPSG--SLRSA---KGSSRGIR---
----------------GWLPSHEGHLD-DGGYTLDLN---MS--------SSRGAIP---
----VKRGPS---SRSG-GPLPKISALS---------------------------AMAR-
S -NSWIGS-QGPMSRGR--ENYGS--------PPCREPTSSWRNDHM-----SRRDDGYA
TKERTHQSSRD-TRDYA-------------------------------------------
----------------------------------PLSRV--YTYRD---YG---------
--------------------------------RSSPDENSSRGYRNRPSSRESRDFALP-
PK---DYTYPDYGRC--SPDEHS-SRGY------SDPDGYSAARGRDHS-EGPSGSSYRD
A--FQGYG----------------------------------------------------
------------------------------------------------------------
-TSHGAPPARGPRMSY----GG--STC-RDY-N-TRDG---------YGRRWESYS----
RSCGDSYSCGR-EHAGRKDQRNLPSLDRLLPAPR-EA-----------------------
YGSSSYVS-STV---DGDES-------------RSEKGD----LSRC-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNLETDE
----KALEAEFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKAAARDMNG
KSLDGKAI-KVAQATKPAFESSRRGPPP---PRSRGRPR--FLRGT---RGGGGGPR---
-----------------RSPSRGGPDD-DGGYTADFD---LR--------PSRAPMP---
----MKRGPP----PRRVGPPPKRAAPS---------------------------GPARS
S -GGGMRG-RALAVRGR--DGYSG--------PPRREPLPPRRDP-----YLGPRDEGYS
SRD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------GYSSRDY---REPRGFAPS-
PG---EYTHRDYGHSS-VRDDCP-LRGYS------DRDGYG-GRDRDYG-DHLSRGSHRE
P--FESYG----------------------------------------------------
------------------------------------------------------------
-ELRGAAPGRGTPPSYG---G---GGRYEEYRG-YSP--------DAYSGGRDSYSS--S
YGRSDRYSRGR-HRVGRPDRGLSLSMERGCPPQ-RDS-----------------------
YSRSGCRV-PRG--GGRLGG-------------RLERGGG---RSRY-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MAESEQPGKIF--------IGGLNLETRQ
----KTLQVIFGRFGPITHV-ILM----RDRETKKS-RGFAFVTFQCPGDAKNAVKEMNG
VSLDGKRI-KVEQARRPSSLERSSKRR-PL-S-FSRTRG--ASRIL---KCGRGGSS---
--------------RGRSRPSRERNLD-DGRYTPNFN---IS--------SSGRHFA---
----VKRSTS---SKRE-GPPSKRSATS---------------------------ALTR-
A-N PGLRG-REPHG--R--EV--------SRNMPRREPVSSRR-----DEYPLPRD----
------------------------------------------------------------
-----------------------------------------DGYSSNDSYS---------
-----------------------------------------------------RRYAS--
-T---SRGYRDYGNYS-SRDEHA-SKVF------SDHAGYHGGRDRDFS-EYLSGSSYRD
T--YESYG----------------------------------------------------
------------------------------------------------------------
-SFHEEPSARGT---Y----TG--NNRYDDYSS-SRGG---------YGGGRETYS----
GSRSDIYG--Y-ERSGRQ--VLPPIDREYSERGGREE-----------------------
RGHSP-MD-RL-----YRAS-------------HESYTI----SSRFGG-----------
------------------------------YHGG--------------------------
--------HEETRYESGGRR----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MMEADRPEKLF--------VGGLNLKTDE
----KALKAEFGKYGHIIKV-FLI----KDRKTNKS-RGFAFVTFESPADAKAAARDMNG
KYLDGKAI-MVAQTIKPAFESSRWV---PP-TPGSGS----RSRFS---HRTRGGGS---
--------------SPQRPPSQGRPDD-GRGYVGYFD---LW--------PYRAPMP---
----RKRGPP---PRHCASPPHKRATLW---------------------------SLAH-
SVGCGMRG-KAPTVSGQ--DGYSGLQPRRWAGPPRKRAAPRSSLARIGGSGMPGKA----
------------------------------------------------------------
-----------------------------------------PAVWGQDGYS---------
---------------------------------------GPWVREPLPSCRDPGDFVPA-
LR---EYSRRYYGHSS-VPDYCP-LRGD------GNRNGYRG-RDHDYT-DHPSKGSYRE
P--LKSYG----------------------------------------------------
------------------------------------------------------------
-GPCGAAPVRGTPPSY----GG--GCCYKEYQG-NSPD---------ACSEGRSS-----
-------------------EALPVVLPDAYSRD---------------------------
--HSP-KA-YSG---GRSSS-------------SNGYSR----SDRYGEEGCYEEYRGRS
PDAHSGGRNSSSNSYGQSHHYGG-EGRYEEYRGRSHEARSGGR---------SDNAYSGG
H----DSSSWSDCCGGGGRYEEYQGR----------------------SWSDRYGVGGHY
EENRGHSLDANSGGRSPDTHSGGRSSSSNSYGQSHRYGGEGHYEYRGRSHDAHSGGCSAD
AYSGGHDSSDQSN-----------------------------------------------
------------------------------------------------------------
--------------RYGGGSRYEEYRGHSLDANSRGRSPDTYSWGYDSSSQSDHYGGGGR
SLDANSSGRLPDAYSGGHDSSSWSHRYGGGGP----------------------------
------------------------------------------------------------
------------------------YSRGRNSFSN------------SYGQSDHYGRGGRY
EEYQGRSPDAYGGGRGLNSSNNSHGRSHRYGGGGR-YEEYRGPSPDAHSGGHDSSIKSYG
LSDRYGGGGHYEEYQGSLPDAYSGDHDRSSNSYGRSDRYSRGRDRVGRPDRGLPLPMETG
SPPLHDSYSLSGCRVPRGGGHQGGRFERGEGQSRY

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------LRGGR-G--GSGGTR---
-----------------GPPSRGGHMD-DGGYSMNFN---MS--------SSRGPLP---
----VKRGPP---PRSG-GPPPKRSAPS---------------------------GPVRS
N--SGMGG-RAPVSRGR--DSYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYAPP-
PR---DYTYRDYGHSS-SRDDYP-SRGYS------DRDGY--GRDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGPPP----SYGG--SSRYDDYSS-SRDG---------YGGSRDSYSS---
-SRSDLYSSGR-DRVGRQERGLPPSMERGYPPP-RD-----------------------S
YSSSSRGA-PRG--GGRGG------SRSDRG---------------GG--RSR------Y
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RRGPPPP-PRSRGPPR--GLRGGR-G--GSGGTR---
-----------------GPPSRGGHMD-DGGYSMNFN---MS--------SSRGPLP---
----VKRGPP---PRSG-GPPPKRSAPS---------------------------GPVR S
S--SGMGG-RAPVSRGR--DSYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYAPP-
PR---DYTYRDYGHSS-SRDDYP-SRGYS------DRDGY--GRDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGPPP----SYGG--SSRYDDYSS-SRDG---------YGGSRDSYSS---
-SRSDLYSSGR-DRVGRQERGLPPSMERGYPPP-RD-----------------------S
YSSSSRGA-PRG--GGRGG------NRSDRG---------------GG--RSR------Y
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFITFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RRGPPPP-PRSRGPPR--GLRGGR-G--GSGGTR---
-----------------GPPSRGGHMD-DGGYSMNFN---MS--------SSRGPLP---
----VKRGPP---PRSG-GPPPKRSAPS---------------------------GPVR S
S--SGMGG-RAPVSRGR--DSYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYAPP-
PR---DYTYRDYGHSS-SRDDYP-SRGYS------DRDGY--GRDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGPPP----SYGG--SSRYDDYSS-SRDG---------YGGSRDSYSS---
-SRSDLYSSGR-DRVGRQERGLPPSMERGYPPP-RD-----------------------S
YSSSSRGA-PRG--GGRGG------SRSDRG---------------GG--RSR------Y
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDQKINKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RRGLPPP-PRSRGPPR--GLRDG---RGGSGGTR---
-----------------GPPSRGGHMD-DGGYSMNFN---MS--------SSRGPLP---
----VKRGPP---PRSG-GPPPKRSAPS---------------------------GPVC S
S--SGMGG-RAPVSHGR--DSYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYAPP-
PR---DYTYRDYGHSS-SHDDYP-SRGYS------DRDGYG--HDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRILVKRLSFYIVLVIIIIH--VRRTNPLRA-TDTG---------EGVTSSLMKS---
-S----------------KPTLPFAFFCFFPFC-CQC-----------------------
VCS---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

--------------------------------VEADCPGKVF--------IGGLSTETSK
----KALEAVFGKYGRIVEA-LLR----KDYETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQAAKLSFESG-RGGLPPP-PRSRGPPR--GLRGG---RGGR-------
------------------EPSRGRHMD-DGGYSMNFN---MS--------SSRGPLP---
----IKGGPP---LRSG-SPPPKTSAPS---------------------------GPVR S
S--SGMGG-RAPVSCGR--DSYGD--------PPRREQLPSGRDV-----YLSPRDDEYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPS-----------
-------------------------SRYS------DRDGYS--RDC----------SYRD
S--HESYG----------------------------------------------------
------------------------------------------------------------
-NSGSAPPTRGPLCGY------------DDYSS-SPDR---------Y----DSYSS---
-SQSDLYSSGG-DRVGRQERG--RGAPRGGGRG-GS--QSDRGGGRSR---Y--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MAETNQPGKIF--------IGGLNIKTRQ
----KTLQEIFGRFGPVARV-ILM----RDRETKKS-RGFAFLTFRRLADAKNAVKEMNG
VILDGKRI-KVKQARRPSSLESGSKKR-PP-S-FSRTRG--ASRIL---KCGRGGRS---
--------------RARSGPSCEGNLG-GDRYTPNFN---VS--------SSGRHFA---
----VKRNPS---SKRD-DPPSKRSATS---------------------------AQTR-
S-NTGLRG-REPHR--R--EI--------SRNMPRGEPASSRR-----DEYPLPRD----
------------------------------------------------------------
-----------------------------------------YGQSSND------------
-----------------------------------------------------RKYES--
-T---SRGYCDYGNYH-SREESA-SKVF------SDHAGYLGGRDRDFS-EYLSGNSYRD
T--YRIYG----------------------------------------------------
------------------------------------------------------------
-RFHEAPSARG----------G--NNRYDDYSN-SQDG---------YGGRGEPYI----
SNRSNIYSSDY-ERSGRQEVLPPPIDREYFDREGRQE-----------------------
RGHSP-KD-GL-----YSAS-------------RESYSS----NTKIWG-----------
------------------------------IPWR--------------------------
--------SWRKQI----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-K VEQATKPTFESG-RRGPPPP-PRSRGPPR--GLRGGR-G--GSGGTR---
-----------------GPPSRGGHMD-DGGYSMNFN---MS--------SSRGPLP---
----VKRGPP---PRSG-GPPPKRSAPS---------------------------GPVR S
S--SGMGG-RAPVSRGR--DSYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYAPP-
PR---DYTYRDYGHSS-SRDDYP-SRGYS------DRDGY--GRDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGPPP----SYGG--SSRYDDYSS-SRDG---------YGGSRDSYSS---
-SRSDLYSSGR-DRVGRQERGLPPSMERGYPPP-RD-----------------------S
YSSSSRGA-PRG--GGRGG------SRSDRG---------------GG--RSR------Y
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALETVFGKYGRIVEV-LLI----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFERG-RHGPPPP-PRSRGPPR--GFGAGR-G--GSGGTR---
-----------------GPPSRGGHMD-DGGYSMNFN---MS--------SSRGPLP---
----VKRGPP---PRSG-GPSPKRSAPS---------------------------GLVR S
S--SGMGG-RAPLSRGR--DSYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYAPP-
PR---DYTYRDYGHSS-SRDDYP-SRGYG------DRDGY--GRDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPLTRGPPP----SYGG--SSRYDDYSS-SRDG---------YGGSRDSYSS---
-SRSDLYS-SC-DRVGRQERGLPPSVERGYPSS-RD-----------------------S
YSSSSRGA-PRG--AGPGG------SRSDRG---------------GG--RSR------Y
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RRGPPPP-PRSRGPPR--GLRGGR-G--GSGGTR---
-----------------GPPSRGGHMD-DGGYSMNFN---MS--------SSRGPLP---
----VKRGPP---PRSG-GPPPKRSAPS---------------------------GPVR S
S--SGMGG-RAPVSRGR--DSYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYAPP-
PR---DYTYRDYGHSS-SRDDYP-SRGYS------DRDGY--GRDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGPPP----SYGG--SSRYDDYSS-SRDG---------YGGSRDSYSS---
-SRSDLYSSGR-DRVGRQERGLPPSMERGYPPP-RD-----------------------S
YSSSSRGA-PRG--GGRGG------SRSDRG---------------GG--RSR------Y
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEI-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RRGPPPP-PRSRGPPR--GLRG------GSGGTR---
-----------------GPPSRGGYMD-DGGYSMNFN---MS--------SSRGPLP---
----VKRGPP---PRSG-GPPPKRSTPS---------------------------GPVR S
S--SGMGG-RAPVSRGR--DSYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYAPP-
PR---DYTYRDYSHSS-SRDDYP-SRGYG------DRDGY--GRDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGPPP----SYGG--SSRYDDYSS-SRDG---------YGGSRDSYSS---
-SRSDLYSSGR-DRVGRQERGLPPSMERGYPPP-RD-----------------------S
YSSSSRGA-PRG--GGRGG------SRSDRG---------------GG--RSR------Y
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

MGCRTSPWLPLVVG---------DSYRLEEKMVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RRGLPPP-PRSRGPPR--GLRGAR-G--GSGGTR---
-----------------GPPSRGGHMD-DGGYSMNFT---MS--------SSRGPLP---
----VKRGPP---PRSG-GPPPKRSAPS---------------------------GPVR S
S--SGMGG-RAPVSRGR--DSYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYAPP-
PR---DYTYRDYGHSS-SRDDYP-SRGYN------DRDGY--GRDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGPPP----SYGG--SSRYDDYSS-SRDG---------YGGSRDSYSS---
-SRSDLYSSGR-DRVGRQERGLPPSMERGYPPP-RD-----------------------S
YSSSSRGA-PRG--GGRGG------SRSDRG---------------GG--RSR------Y
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------IVEADRQEKLF--------IGGLNKEINE
----KALEAVFGKYERIMEA-LLM----KDRETNKS-RGFAFVTFETPADTKDATWDMNG
KSFDGKAI-KVEQATKASFESR----------------------------GGSGGTR---
-----------------GPPSHGGS--------------------------SRGPLP---
----HH--------PEVGGPPPKRSAPS---------------------------GQVH S
S--SGMGG-RAPVSHGR--DSFGG--------PPRREPLPSPRDV-----YLSPRDGGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDHPSSRDTRDY----
---------HDYGHSS-SHDDYP-SRGYS------DRDGYG--RDRDYS-DHPSGDLHRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSHGAPPTRGPP------------SLYDNYSS-SRDE---------YGGSRDSYSS---
-SQSDLYSSGR-NWVGRQERGLPSSTERGYPPP-RDS-----------------------
YSSSRRGA-PRG--GGHKGR-------------LSDTGGS---RSRY-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-K VEQATKPSFESG-RRGPPPP-PRSRGPPR--GLRGGR-G--GSGGTR---
-----------------GPPSRGGHMD-DGGYSMNFN---MS--------SSRGPLP---
----VKRGPP---PRSG-GPPPKRSAPS---------------------------GPVR S
S--SGMGG-RAPVSRGR--DSYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYAPP-
PR---DYTYRDYGHSS-SRDDYP-SRGYS------DRDGY--GRDRDYS-DHPSGGSYRD
S--YESYS----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGPPP----SYGG--SSRYDDYSS-SRDG---------YGGSRDSYSS---
-SRSDLYSSGR-DRVGRQERGLPPSMERGYPPP-RD-----------------------S
YSSSSRGA-PRG--GGRGG------SRSDRG---------------GG--RSR------Y
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RRGPLHL--QEAEPSR--GLRGGR-G--GSGGTR---
-----------------GPPSRGGHMD-DGGYSMDFN---MS--------SSRGPLP---
----VKRGPP---PR----------------------------------------RPVR S
S--SGMGG-RAPVSRGR--DSYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYAPP-
PR---DYTYRDYGHSS-SRDDYP-SRGYS------DRDGY--GRDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGPPP----SYGG--SSRYDDYSS-SRDG---------YGGSRDSYSS---
-SRSDLYSSGR-DRVGRQERGLPPSMERGYPPP-RD-----------------------S
YSSSSRGA-PRG--GGRGG------SRSDRG---------------GG--RSR------Y
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADHPGKLF--------IGGLNRETNE
----KMLKAVFGKHGPISEV-LLI----KDR-TSKS-RGFAFITFENPADAKNAAKDMNG
KSLDGKAI-KVEQAKKPSFQSDGRRRPPAS-SRNRSPSE--SLRSA---RRNSGGTR---
----------------GWLPSHEGHLD-DGGYTPDLN---MS--------YSRGLTP---
----VKRGPS---SRSG-GPPPKKSAPS---------------------------AVAR-
S -SSWMGS-QGPMSQRR--ENYGV--------PPRRGTISSWRNDRMS-----PRYDGYA
TNDGNHPSCQ-ETRDYAP---PSRGYAYRDNGHSNRDEHSSRGYRNHRSSRETRDYPPPS
RGHAYRDYGHSRRHESYSRGYRNHPSSRETRDYAPPSR-------D---YGHSRQDEHSS
RGYRYC--NFFWIYQIDF---------LYCSF---------QITL---------DYTPP-
PR---DYAYHDYGHS--SWDEHS-SRGY------SYHDGYGEALGRDHS-EHLSGSSYRD
A--FQGYG----------------------------------------------------
------------------------------------------------------------
-TSHDAPPARGPRMSY----GG--STC-HAYSN-TRDR---------YGRSWESYS----
RSCGDFHYCDH-EHVCRKDQRNPPSLGRVLPDPR-EA-----------------------
YGSSLYVA-SIV---DGGES-------------RSEKGD----SSRY-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MFEADHPGKLF--------FSGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDPETNKS-GGFAFVTFE------DAARDMNG
KSLDGKAI-KVEQVTKPSFESG-RRGPPPP-PRSRGPPR--GLRGG---RRG--------
------------------------------------------------------------
----IQRGPP---PKNE-GPPPKRSALS---------------------------RPVSS
S--SGKGG-RAPV---------SR--------PLGREPLPSSRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTR------
----------DYGHSS-SRDDYL-SRGYS------DRDGYG--RDRDYS-DHPSGVSYRD
A--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSALPTRGPPPSY----GG--SSPYDDYSS-SRDG---------Y----DSHSS---
-SRSDLYSSGR-DRVGRQERGLHSSMERGCPPP-RDS-----------------------
YRSSSCGA-PRD--GGRGG------R------------GG---RSRY-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVVADCPGKFF--------IVGLNMETNE
----KALEAPFGKYGRIV----------NSGTTKQ----------------------SLE
--------------------SG-RCGPPTL-PRSRGPPR--GLRGG---RGGSGGTR---
-----------------EPPSWGRYMD-DGGYSMHFN---TR---------TREPLP---
----VKRGPS---PRSG-GPSPKRSAPS---------------------------GPVHS
S--SGMEG-RAPLSHGR--DSYGG--------PPRRELPPSRRDV-----YLSPRDDAYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SSSSRDYPSSRDTRDYAPP-
LR---DYTYHDYGHSH-SCDGHP-SRGYS------DRDGYD--RDHDYS-DHPSGSSYRD
S--YESYD----------------------------------------------------
------------------------------------------------------------
-NSHSAPPKQGPPPFY----AG--SSLYHDYSS-SRDG---------YGRSEDSYSS---
-SRSDLHSSG-----R---D----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------------MGKLF--------IAGLNTETKE
----KVLEAVFGKYGRIVEV-LLM----KDQEINQS-RGFAFVTFESPADAKDAARDMNG
RSVDGKAF-KVEQATKPTFKSCGCGPPPLP-R-S-RSPL--GLEGR---RGGSRRTR---
-----------------GPHSRRGGTE-GNSYESYSNSSSAP--------RTRGSLT---
----FSGG----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAIFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-K VEQATKPSFETG-RRGPPPP-PRSISPPR--GLRGGR-G--GSGGAR---
-----------------GPPSRGGHM---------------S--------SSRGPLP---
----VKRGPP---PRSG-GPPAKRSAPS---------------------------GPVR S
S--SGMGG-RAPVSRGR--DSYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYASP-
PR---GYTYCDYGHSS-SRDDYP-SRGYS------DRDGY--GRDRDYS-DHPSGGSYRD
S--YDSYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGSPP----SYGG--SSRYDDYSS-SRDG---------YGGSRDSYSS---
-SRSDLYSSG--------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

------------------------------KMVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RRGPPPP-PRSRGPPR--GLRGGR-G--GSGGTR---
-----------------GPPSRGGHMD-DGGYSMNFN---MS--------SSRGPLP---
----VKRGPP---PRSG-GPPPKRSAPS---------------------------GPVR S
S--SGMGG-RAPVSRGR--DSYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYAPP-
PR---DYTYRDYGHSS-SRDDYP-SRGYS------DRDGY--GRDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGPPP----SYGG--SSRYDDYSS-SRDG---------YGGSRDSYSS---
-SRSDLYSSGR-DRVGRQERGLPPSMERGYPPP-RD-----------------------S
YSSSSRGA-PRG--GGRGG------SRSDRG---------------GG--RSR------Y
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADCPGKLF--------IGGLNTETKE
----KALEAVFGKYGQIVEI-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKLP----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNLETDE
----KALEAEFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKAAARDMNG
KSLDGKAI-KVAQATKPAFESSRRGPPP---PRSRGRPR--FLRGT---RGGGCGPR---
-----------------RSPSRGGPDD-DGGYAGDFD---LR--------PSRARMP---
----MKRGPP-P--PRRSGPPPKRAAPS---------------------------GPARS
S -GGGMRG-RSLAVRGR--DGYSG--------PPRREPLPPRRDP-----YLGPRDEGYS
SRD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------GYSSRDY---REPRGFAPS-
PR---EYTHRDYGHSS-VRDDCP-LRGYS------DRDGYG-GRDRDYG-DHLSRGSYRE
P--FESYG----------------------------------------------------
------------------------------------------------------------
-DLRGAAPGRGTPPSYG---G---RGRYEEYRG-CSP--------DAYSGGRDSYSS--S
YGRSDHYSRGR-DRVGRPDRGLSLSMERGCPPQ-RDS-----------------------
YSRSGCRV-PRG--GGRLGG-------------RLERGGG---RSRY-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RRGPLPP-PRSRGPPR--GLRGGR-G--GSGGTR---
-----------------GPPSRGGHMD-DGGYSMNFN---MS--------SSRGPLP---
----VKRGPP---PRSG-GPPPKRSAPS---------------------------GPVR S
S--SGMGG-RAPVSRGR--DSYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYAPP-
PR---DYTYRDYGHSS-SRDDYP-SRGYS------DRDGY--GRDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGPPP----SYGG--SSRYDDYSS-SRDG---------YGGSRDSYSS---
-SRSDLYSSGR-DRVGRQERGLPPSMERGYPPP-RD-----------------------S
YSSSSRGA-PRG--GGRGG------SRSDRG---------------GG--RSR------Y
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

---------------------------------EAGHPGKLF--------FGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDLETNKS-RGFAFVTFE------DAARDMNG
KSLDGKAI-KVEQVTKPSFESG-RRGLPPP-PRSRGPPR--GLRGE---RRGSGGTR---
-----------------GPPSREGHMD-DNEYYMNFN---MS--------SSRGPLP---
----VKRGLP---PGSG-GPLPRDLHLQ---------------------------DQLAS
S--CIT---WKRQ---------GG--------PPGREPLPSSRDV-----YLSQRDDEYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSNRYYPSSRDTRDYAPP-
PR---DYTYRDYGHSS-SRDDYQ-E--AI------ARDGYG--RDRDYS-DHPSGSSYRD
A--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGPSPSY----GG--SSPYDDYSN-S-------------------YSS---
-SRSDLYSTGR---------------DRGYPPP-RDS-----------------------
YSSSSHRA-PRD--GGRGG------R------------GG---RSRY-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGQIVEI-FWI----KNRETNKS-RSFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RRGPPPP-PRSRGPPR--GLRGG---SG---GAR---
-----------------GPP---------------------S--------SSRGPLP---
----IKRGPP---PQ----------------------------------------RPVR S
S--SGMGG-RAPVSRRR--DSYRG--------PPRKETPPSRRDV-----YLSRRDDGYL
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRYTRDYATT-
KR-------------------LC-LPGYG------DRDGYG--WYHDHS-DHPSGGSYRD
S--YESYS----------------------------------------------------
------------------------------------------------------------
-NSLTAPPTRGPLPLY----RG--SSRYDDCSS---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MAETDQPGKIF--------IGGLNIKTRQ
----KTLQEIFGRFGPVARV-ILM----RDRETKKS-RGFAFLTFRRLADAKNAVKEMNG
VILDGKRI-KVKQARRPSSLESGSKKR-PP-S-FSRTRG--ASRIL---KCGRGGRS---
--------------RARSGPSCEGNLG-GDRYTPNFN---VS--------SSGRHFA---
----VKRNPS---SKRD-DPPSKRSATS---------------------------AQTR-
S-NTGLRG-REPHR--R--EI--------SRNMPRGEPASSRR-----DEYPLPRD----
------------------------------------------------------------
-----------------------------------------YGQSSND------------
-----------------------------------------------------RKYES--
-T---SRGNCDYGNYH-SREESA-SKVF------SDHAGYLGGRDRDFS-EYLSGNSYRD
T--YRSYG----------------------------------------------------
------------------------------------------------------------
-RFHEAPSARG----------G--NNRYDDYSN-SQDG---------YGGRGEPYI----
SNRSNIYSSDY-ERSGRQEVLPPPIDREYFDREGRQE-----------------------
RGHSP-KD-GL-----YSAS-------------RESYSS----NTKIWG-----------
------------------------------IPWR--------------------------
--------SWRKQI----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

------------------------------KMVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RRGPPPP-PRSRGPPR--GLRGGR-G--GSGGTR---
-----------------GPPSHGGHMD-DGGYSMNFN---MS--------SSRGPLP---
----VKRGPP---PRSG-GPPPKRSAPS---------------------------GPVR S
S--SGMGG-RAPVSRGR--DSYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYAPP-
PR---DYTYRDYGHSS-SRDDYP-SRGYS------DRDGY--GRDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGPPP----SYGG--CSRYNDYSS-SRDG---------YGGSRDSYSS---
-SRSDLYSSGR-DRVGRQERGLPPSMERGYPPP-RD-----------------------S
YSSSSRGA-PRG--GGRGG------SRSDRG---------------GG--RSR------Y
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RRGPPPP-PRSRGPPR--GLRGGR-G--GSGGTR---
-----------------GPPSRGGHMD-DGGYSMNFN---MS--------SSRGPLP---
----VKRGPP---PRSG-GPPPKRSAPS---------------------------GPVR S
S--SGMGG-RAPVSRGR--DSYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYAPP-
PR---DYTYRDYGHSS-SRDDYP-SRGYS------DRDGY--GRDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGPPP----SYGG--SSRYDDYSS-SRDG---------YGGSRDSYSS---
-SRSDLYSSGR-DRVGRQERGLPPSMERGYPPP-RD-----------------------S
YSSSSRGA-PRG--GGRGG------SRSDRG---------------GG--RSR------Y
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------------PGKLF--------LGGLNTETNE
----KALETVFGKYGQIVEV-LLM----KDQETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQAMKPSFESG-RRGPPPP-PRSRGPPR--GLRGG---RGGSGGTR---
-----------------GPPSHGGHMD-DGGYSMNFN---MS--------SSRGPLP---
----VKRGPP---PRSG-GPPPKRSALS---------------------------GPLQR
P--SSKGT-------------------------------PAFSQR-----CLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSNRDYPNSHDTRDYAP--
PR---DYTYRDYGHSS-SRDDYP-SRGYN------DRDGYG--WDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSR------------------------------------------------NSYSS---
-SQSDLSSSGR-DRVGRQERGLPTSMERGYPPP-HDS-----------------------
YSSSSRGA-PRS--GGHGG------S-------RSDRGGG---RRRY-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-K VEQATKPSFETG-RRGPP---------PR--GLRGGG-G--GRGGTR---
-----------------GPPSCGGHMD-DGGYSMNFN---MS--------SSRGPLP---
----VKRGPP---PRSG-GPPAKRSAPS---------------------------GPVR S
S--SGMGG-RAPVSRGR--DSYGG--------PPRREPLPSHRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYASP-
PR---GYIYRDS---S-SRDDYP-SRGYS------DRDGY--GRDRDYS-DHPSGGSYRD
S--YDSYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGPPP----SYGG--SSRYDDYSS-SRDG---------YGGSRDSYSS---
-SRSDLYSSGC-DWVGRQERRLPPSRERGYPPP-RD-----------------------S
YSSSSRRA-PRG--GGRGG------NLSDRG---------------GG--RSR------Y
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVVADCPGKFF--------IVGLNMETNE
----KALEAPFVEVLLMK-----------DREANKS-RGFAFVTFESPADAKDATRDMNG
--------------------K-----------------------------GGSGGTR---
-----------------EPPSWGGHMD-DGGYSMHFN---TS--------SSREPLP---
----VKRKPS---PRSG-GPSPKRSAPS---------------------------GPVH S
S--SGMEG-RAPLSHGR--DSYGG--------LPRRELLPSRRDV-----YLSTRDDVYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SSSSRDYPSSRDTREYAPP-
SR---DYTYHDYGHSS-SRDDHP-SRGYS--------DGYD--RDHDYS-DHPSGSSYRD
S--YESYD----------------------------------------------------
------------------------------------------------------------
-NSYSAPPTQGPPPFY----AG--SSPYHDYSS-SHDG---------YGRSQDSYSS---
-SRSDLYSSG-----RD-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNPETDE
----KALEAAFGKYGRIIEV-LLM----KDRETSKS-RGFAFVTFESPADAKAAARDMNG
KSLDGKAI-KVAQATKPAYESSRRRDRRCP----RSRVI--V---------YSTTTH---
-----------------RFPNSES--------------------------KRR-------
----------------R-ARPAPEEVAP---------------------------SSL-S
RSGGEMRG-RAPTARGR--DGY----------------------P-----YLGPREEGYS
PRDS--------------------------------------------------------
-------------------------------------------------YS---------
-------------------------------------------SRDYPSA---RDFAPS-
PR---EYTYRDYGHSS-ARDDCP-SRGY------GDRDGYGGRD-RDYA-DHSSGGSYRD
P--FESYG----------------------------------------------------
------------------------------------------------------------
-DPRGAASARGPPPSY----GG--GGRYEEYRGCSPDA---------YGGGRDSYG----
SSRSDRYSRGR-DRVGRPDRGLPPSMERGCPP-PRDS-----------------------
YSRSGRRA-PRG--GGRLGS-------------ER--GEG---RSRY-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVVADCPGKFF--------IVGLNMETNE
----KALEAPFGKYGRIV----------NSGSTLDE-RPICFCHLESPADAKDAARDMN G
--------------------NG-RRGPPTL-PRSRGPPR--GLRGG---RGGSGGTR---
-----------------KPPSWGGHMD-DGGYSMHFN---TS--------SSREPLP---
----VKRGPS---PRSG-GPSPKRSAPS---------------------------GPVH S
S--SGMEG-RAPLSHGR--DSYGG--------LPRRELPPSCRDV-----YLSPRDDAYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SSSSRDYPSSRATRDYAPP-
PR---DYTYHDYGHSR-SCDGHP-SRGYS------DRDGYD--RDHNYS-DHPSGSSYRD
S--YESYD----------------------------------------------------
------------------------------------------------------------
-NSHSAPPKQGPPPFY----AG--NSLYHDYSS-SRDG---------YGRSEDSYSS---
-SRSDLHSSG-----R---D----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNLETDE
----KALEAAFGKYGRIIEV-LLM----KDRETSKS-RGFAFVTFESPADAKAAARDMNG
KSLDGKAI-KVAQATKPAFDSSRRGPPPP--PRSRGRPR--GLRGV---R----------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------GEPPPPRRDP-----YLGPREEGYS
PRD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------GYSSRDYPSARDPRDFAPS-
PR---EYTYRDYGHSS-ARDDCP-SRGYG------DRDGYG-GRDRDYA-DHPSGG-YRD
P--FDSYG----------------------------------------------------
------------------------------------------------------------
-DPRSAAPARGPPPSYG---G---GGRYEEYRG-CSP--------DAYGGGRDSYAS---
-GRSDRYSRGR-DRVGRPDRGLPPSMERGCPPP-RDS-----------------------
YSRSGRRV-PRG--GGRLGS-------------RSERGGG---RS--RY-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RRGPPPP-PRSRGPPR--GLRGGR-G--GSGGTR---
-----------------GPPSRGGHMD-DGGYSMNFN---MS--------SSRGPLP---
----VKRGPP---PRSG-GPPPKRSAPS---------------------------GPVR S
S--SGMGG-RAPVSRGR--DSYGG--------PPRREPLPSHRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYAPP-
PR---DYTYRDYGHSS-SRDDYP-SRGYS------DRDGY--GRDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGPPP----SYGG--SSRYDDYSS-SRDG---------YGGSRDSYSS---
-SRSDLYSSGR-DRVGRQERGLPPSMERGYPPP-RD-----------------------S
YSSSSRGA-PRG--GGRGG------NRSDRG---------------GG--RSR------Y
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RRGPPPP-PRSRGPPR--GLRGGR-G--GSGGTR---
-----------------GPPSRGGHVD-DGGYSMNFN---MS--------SSRGPLP---
----VKRGPA---PRSG-GPPPKRSAPS---------------------------GPAR S
S--SGMGG-RAPVSRGR--DSYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SDSSRDYPSSRDTRDYAPP-
PR---GYTYRDYGHSS-SRDDYP-SRGYS------DRDGY--GRDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSLLLNVLLAIVT--RFIF--TF--LPIIL-RI------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESGGRRGPPPP-PRSRGPPR--GLRGGR-G--GS-GAR---
-----------------GPPSRGSHL---------------G--------SSRGPLP---
----MKRGPP---PRSG-GPPPKRSAPS---------------------------GPV RS
S---SMGG-RAPVSRGR--DSYGG--------PPRREPMPSRRDV-----YMSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------GYSSRDYPSSRDTRDYAPP-
PR---DYAYRDYGHSS-SRDEYP-SRGYSLSSYS-DRDGYGGGRDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPARGPPP----SYGG--SSRYDDYGS-TRDG---------YG-SRESYSS---
-SRSDVYSSGR-DRVGRQDRGLPPSMERGYPPP-RD-----------------------S
YSSSSRGA-PRG--GGRGG------SRSDRG---------------GG--RSR------Y
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RRGLPPP-PRSRGPPR--GLRGGR-G--GSGGTR---
-----------------GPPSRGGHMD-DGGYSMNFN---MS--------SSRGPLP---
----VKRGPP---PRSG-GPPPKRSAPS---------------------------GPVR S
S--SGMGG-RAPVSRGR--DSYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
-KD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYAPP-
PR---DYTYRDYGHSS-SRDDYP-SRGYS------DRDGY--GRDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGPPP----SYGG--SSRYDDYSS-SRDG---------YGGSRDSYSS---
-SRSDLYSSGR-DRVGRQERGLPPSMERGYPPP-RD-----------------------S
YSSSSRGA-PRG--GGRGG------SRSDRG---------------GG--RSR------Y
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNLETDE
----KALEAAFGKYGRIIEV-LLM----KDRETSKS-RGFAFVTFENPADAKAASRDMNG
NIYFYH------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAMTGKIGSEMEI-SLQ----IETKTSDIQRGSGLQ---SHAQTCLCHNGLVG
GTLNHGVT--------------KMCNFCIF-FV---------------------------
------RESVLFVRWLSIIPG-VCNVA-CGDL------------LHPP--HLASDGGSSR
GQMPLKRGPP---PRSG-GPPPKRSAPS---------------------------GPVR-
--SSGMGG-RAPLSRER--DGYGA--------PPRRDPIPSRRDV-----YMSPRDDGYS
GKDR--------------------------------------------------------
-------------------------------------------------YS---------
-------------------------------------------GRDYGSSRDSRDYGPP-
PR---DYAYRDYGHSS-SRDDYG-SRGYSS-AVFSDRDGYGGRDSRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPARGPPPSY----GG--SSRYDDYGS-TRDG---------Y-GGRDSYS----
SSRNDIYSSGR-DRVGRQERGLPPPMDRGYPP-PRDS-----------------------
YSSSSRGG-PRG--GGRGGS-------------RSDRGGG---RSRY-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MIKADSPGKLF--------IGGLNTETNE
----KDLEAVFGKYGRIVEL-LLM----KDHETNRS-RGFAFVTFECPADANDAAQDMNG
KSLDGKAI-KVEQASKSSFDSG-RHGPPPL-PRSRGPPR--GLRGG---RGGRGGTW---
-----------------RHPSGGGHME-DGDYSFNFN---RS--------SFRGPLP---
----TKRGLL---PGIG-CPPPKKSASS---------------------------GPVS -
S--GGMGG-RAPISHGR--DGYGD--------PPRRGALPSHRDV-----YLAARNDGYF
TKH---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSFYNKRDYAPS-
AR---DYTYSDYGHSR-SRDDYP-SRGYS------DRDGYS--CDRDYS-DHLSGRLFRG
S--YESYC----------------------------------------------------
------------------------------------------------------------
-NSCSAQPTQRPPASY----GG--SPRYKDYSG-SCAR---------YGGSRNSYTN---
-SRRDVRSSRR-DRVGKQGRGRSPSMERGYP-P-RDS-----------------------
YSHSRLTA-PRR--DGLGG------S-------RSSKGGE---RSIS-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

------------------------------KMVEVHHPGKLF--------IVGS-TETNK
----KALEAVFGKYGRIVEV-LLM----KDHETNKL-RGFAFVLIVSLADTKDAVSDRNG
KSLDGKAI-KVE----PSFENGRH--GPLLSARNRGPFR--SFRGR---KGRSGGTR---
-----------------ERPSYGGHMD-DGGYSMNFN---MS--------FSRGPLP---
----VKRGPP---PKSG-GPPPKRSAQS---------------------------GSL--
C SSSGMGR-RAPLSQGR--DGYGS--------PLRTEPLPYQTDV-----YLSPRDDGYY
HKEC--------------------------------------------------------
-------------------------------------------------YS---------
------------------------------------------SRSYPS--YHARDYEPP-
PR---DYTCRDYGHSS-SCDDCP-SRGY------NDRDGYGCD--QEYS-GHPRGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-DSHS-PTWGRPPPSY----GG--SSCYGDYRS-SCDI---------YGRSRDSSS----
SSQSDLYSSGH-DWTDRPKRGLPPE-ERVSPP-PHDS-----------------------
YSIPNHGV-LRC--GGHEGS-------------QSDKGEA---EEDA-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADHPGKLF--------IGGLNRETNE
----KMLKAVFGKHGPISEV-LLI----KDR-TSKS-RGFAFITFENPADAKNAAKDMNG
KSLHGKAI-KVEQAKKPSFQSGGRRRPPAS-SRNRSPSG--SLRSA---RGSRGGTR---
----------------GWLPSQEGHLD-DGGYTPDLK---MS--------YSRGLIP---
----VKRGPS---SRSG-GPPPKKSAPS---------------------------AVAR-
S -NSWMGS-QGPMSQRR--ENYGV--------PPRRATISSWRNDRMS-----TRHDGYA
TNDGNHPSCQ-ETRDYAP---PSRGYAYRDNGHSNRDEHSSRGYRNHRSSRETRDYAPPS
RGHAYRDYGHSRRDESYSRGYRNRRSSRETREYAPPSRG--HGYRD---YGHSRRHESYS
RGYR-----------------------------------------NHPSSRETRDYAPP-
HR---DYAYRDYGHS--SWDEHS-SRGY------SYHDGYGEALGRDHS-EHLSGSSYRD
A--LQRYG----------------------------------------------------
------------------------------------------------------------
-TSHGAPPARGPRMSY----GG--STC-HAYSN-TRDR---------YGRSWESYS----
-SCGDFHYCDR-EHVCRKDQRNPPSLGRVLPDPR-EA-----------------------
CGSSSYVA-SIV---DGGES-------------RSEKGD----SSRY-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFEGG-RRGPPPP-PRSRGPPR--GLRGGR-G--GSGGTR---
-----------------GPPSHGGHMD-DGGYSMNFN---MS--------SSRGPLP---
----VKRGPP---PRSG-GPPPKRSAPS---------------------------GPVR S
S--SGMGG-RAPVSRGR--DSYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYAPP-
PR---DYTYRDYGHSS-SRDDYP-SRGYS------DRDGY--GRDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGPPP----SYGG--SSRYDDYSS-SRDG---------YGGSRDSYSS---
-SRSDLYSSGR-DRVGRQERGLPPSMERGYPPP-RD-----------------------S
YSSSSRGA-PRG--GGRGG------SRSDRG---------------GG--RSR------Y
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------VVEADCPGKPF--------TGGLNTETNE
----KALEAVF------VEV-LLM----KDHETNKS-RRFAFVTFESPADAKDAARDMNG
KSLDGKA V-EVEQATKPSFESG-RRGPPPP-PRSRGPPR--GLRGG---RGGSGGTR---
-----------------GPLSRGGHMD-DGGYSMNFN---MS--------SSRGPHP---
----VKRGPP---PRSG-SPPSKRSAPS---------------------------RPVR S
S--SGMGG-RAPVSRGG--DSYGS--------PPRRELLPSCRDD-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSHDTRAYAPP-
PR---DYTYRDYGHSS-SR--------YS------DRDRYG--RDRDYS-DHPGGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGPPPSY----GG--SSRCDDYSS-SRDG---------YGRSRDSYSS---
-SRSDLYSSGR-DRVGRQERGLTPSMERGYPPP-RDS-----------------------
YSSSSAEH-QAV--VAVEE------ADLIEGEAEADIRNK---QNFGPKSQF--------
KETK-------SGSYSIITTQGLLKGKIV-------------------------LLF---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RRGLPPP-PRSRGPPR--GLRGGR-G--GSGGTR---
-----------------GPPSRGGHMD-DGGYSMNFT---MS--------SSRGPLP---
----VKRGPP---PRSG-GPPPKRSAPS---------------------------GPVR S
S--SGLGG-RAPVSRGR--DGYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSREYPSSRDTRDYAPP-
PR---DYTYRDYGHSS-SRDDYP-SRGYS------DRDGY--GRDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGPPP----SYGG--SSRYDDYSS-SRDG---------YGGSRDSYSS---
-SRSDLYSSGR-DRVGRQERGLPPSMERGYPPP-RD-----------------------S
YSSSSRGA-PRG--GGRGG------SRSDRG---------------GG--RSR------Y
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNLETDE
----KALEAEFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKAAARDMNG
KSLDGKAI-KVAQATKPAFESSRRGPPP---PRSRGRPR--FLRGT---RGGGGGPR---
-----------------RSPSRGGPDD-DGGYAGDFD---LR--------PSRAPMP---
----XXXX--PP--PRRAGPPPKRAAPS---------------------------GPARS
S -GGGMRG-RALAVRGR--DGYSG--------PPRREPPPPRRDP-----YLGPRDEGYS
SRD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDY---REPRGFAPS-
PR---EYTHREYGHSS-VRDDCP-LRGYG------DRDGYG-CRDRDYG-DHPSRGSYRE
P--FESYG----------------------------------------------------
------------------------------------------------------------
-DLRGGAPGRGTPPSYG---G---GGRYEEYRG-CSP--------DAYSGGRDSYSS--S
YGRSDRYSRGR-DRVGRPDRGLSLSMERGCPPQ-RDS-----------------------
YSRSGCRV-PRG--GGRLGG-------------RMERGGG---RSRY-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADCPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIMEV-LLM----KDQETNKS-RGFAIVTFESPADAKEATRDMNG
KSLDGKAI-KVEQATKVSFESG-RRGTPPP-PRSRGPPR--GLRGGR-G--GSGGTR---
-----------------GPPSHGGHMD-DGGYSINFN---MS--------SSKGPLP---
----VKRGPP---PRSG-APPPKRLASS---------------------------GPVC S
S--SEMGG-RAPVPHGR--DSYRG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSHDRRDYAPP-
PK---DYTYRDYCHSS-SRDDYP-SRGYR------DRDGY--GRDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSHGAPPTRGPLP----TYGA--SSRYDDYSS-SRDG---------YGGS---------
----------------RDKRGLPPSMERGYPPP-RD-----------------------S
YNSSSHGA-PRG--GGHGG------SRSDRG---------------GG--RSR------Y
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

--------------------------------MIADRPK-LF--------IGGLXXXXXX
----XXXXXXXXXXXXXXXX-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-K VEQATKPSFESG-RRGPPPP-PRSRGPPR--GLRGG---RGGSGGAR---
-----------------GPPSRGGHMD-DGGYSMNFN---MS--------SSRGPLP---
----VKRGPP---PRSG-GPPPKRSAPS---------------------------GPVR S
S--SGMGG-RAPVSRGR--DSYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYAPP-
PR---DYTYRDYGHSS-SRDDYP-SRGYS------DRXXXX--XXXXXX-XXXXXXXXXX
X--XXXXX----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGPPPSY----GG--SSRYDDYSS-SRDG---------YGGSRDSYSS---
-SRSDLYSSGR-DRVGRQERGLPPSMERGYPPP-RDS-----------------------
YSSSSRGA-PRG--GGRGG------S-------RSDRGGG---RSRY-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKFF--------IGGLNTETNK
----KALEAVFGKYGQIVEV-HLM----KDCETNKS-RGFAFITFESPADAKDAARDMNG
KPISLMNI-DVKSP----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNHETDE
----KSLEAAFGKYGHISEV-LLM----KDRETNKS-RGFAFITFESPADAKAAVRDMNG
KSLDGKAI-KVAQATKPAFESGRRGPPL---SRS--------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------RYGGGRDGYAG---
-GRSERYSGGR-DRVGRADRGLPQSVERGCPPP-RES-----------------------
YSRSGRKV-PRG--GGRLGS-------------RSERGGG---G-RSRY-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADHPGKLF--------IGGFNRETNE
----KMLKAVFGKHGPISEV-LLI----KDR-TSKS-RGFAFITFENPADAKNAAKDMNG
KSLDGKAI-KVEQAKKPSFQSDGRRRPPAS-SRNRSPSG--SLRSA---RGSSGGTR---
----------------GWLPSHEGHLD-DGGYTPDLK---MS--------YSRGLTP---
----VKRGPS---SRSG-GPPLKKSAPS---------------------------AVAR-
S -SSWMGS-QGPMSQRR--ENYGV--------PPRRGTISSWRNDRMS-----PRYDGYA
TNDGNHPSCQ-ETRDYAPPSPPSRGYAYRDN--------------------ETRDYAPPS
RGHAYRDCGHSRRHETYSRGYRNHRSSRETRDYPPTSRG--HAYHD---YGHSRRHESYS
RGYR-----------------------------------------NHLSSRETRDYAPP-
SR---D-----YGHS--RQDEHS-SRGY------RYY----------HS-EHLRGSSYRD
A--FQGYG----------------------------------------------------
------------------------------------------------------------
-TSHDAPPARGPRMSY----GG--STC-HAYSN-TRDR---------YGRSWESYS----
RSCGDFHYCDR-EHVCRKDQRNPPSLGRVLPDPR-EA-----------------------
YGISSYVA-SIV---DGGES-------------RSEKGD----SSRY-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADGPGKLF--------IGGLNTETNE
----KAFEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPEDAKDAARDMNG
QSLDGKLLYHVEEIVMEAHLEGNPCPLVEM-FICPQKMMDILLKTA---IQGEIIQVLMI
PQIMYHDQEIILTVIM-VIPVHVMTLH-QEAMVIEMD---MAVMVTIQIIQVEAPTEIHM
RVVAA-HVVL---HLHE-APPSYGGSSRSDDYSSS--PD---------------------
GYGGSRDS-YSSSR--S--DLY--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNPETDE
----KALEAAFGKYGRIVEV-LLM----KDRETSKS-RGFAFVTFESPADAKAAARDMNG
KSLDGKAI-KVAQATKPAFESSRRGPPPPP-PRSRGRLR--GLRGT---RG---GPR---
-----------------RPPSRGGPAD-DGDYAGDFD---LR--------PPRAPMP---
----MKRGPP----PRRAGPPPKRAVPS---------------------------GPVRS
GG GGGMRG-RAPASRGR--DSYGG--------PPRREPPPPRRDH-----YLGPREEGYS
PRD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSTRDPRDFAPS-
PR---EYTYRDYGHSS-ARDDCP-SRGYG------DRDGYG-GRDRDYG-DHPSGGSYRD
P--FESYG----------------------------------------------------
------------------------------------------------------------
-DPRSAAPARGPPPSYG---G---GGRYEEYRG-CSP--------DAYSGGRDSYGS---
-GRSDRYSRGR-ERVGRVDRGLPPSMERGCPPP-RDS-----------------------
YSRSGRRV-PRG--GGRLGG-------------RSERGGG---RS--RY-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

--------------------------------VEADHPGKLF--------I---------
-----ALEAVFGKYGRIVEV-LLM----KDLETNKS-RRFAFVTFESPEDAKDAARIMNG
KSLDGKAI-KVEQATKPSFESS-RHGPPLP-------PR--GLRDG---RGGSGGTR---
-----------------RPPSWGGHMD-DGGYSMNFN---MN--------SSRGPLP---
----VKRGLP---PRSG-GPPPKRSAPS---------------------------GPVG S
S--SGMGG-RAPVSHGR--DSYGG--------LPRREPPPSRRDV-----YLPPRDDGYS
TKA---------------------------------------------------------
------------------------------------------------------------
---------------------------------------------DYPSSHNTRDYVPP-
PR---DYTYRDYGHSS-SRDDYP-SRGYK------MGCRDG--YGR--------HHSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSHSAPPTRGPPPSY----GG--SNHYDVYSS-SRDG---------YGGSQGNYSS---
-SQSDLYSSGR-DRVGRQERGLPPSMERGYPPP-CDS-----------------------
YSR----A-PRG--GGSGG------S-------RSDRRGG---RSRY-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KLFKG KHG-GHPKLNYSQVMV---------------------------------------
------------------------------------------------------------
---------------------HAVVLFC---------------------------RENTP
K--MLFDR-Y SPVSRGR--DSYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKDRRAQHKKHTS-----------------------------------------------
------------------------------------------------------------
----------------------------------NYFCFSSYSSRDYPSSRDTRDYAPP-
PR---DYTYRDY-------------------------DGYG--RDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGPPPSY----GG--SSRYDDYSS-SRDG---------YGGSRDSYSS---
-SRSDLYSSGR-DRVGRQERGLPPSMERGYPPP-RDS-----------------------
YSSSSRGA-PRG--GGRGGS-------------RSDRGGG---RSRY-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVVADCPGKFF--------IVGLNMETNE
----KALEAPFVEVLLMK-----------DREINKS-RGFAFVTFESPADAKDAARDMNG
--------------------KL-LDGK---------------------------------
-------------------AI KGGHMD-DGGYSMHFN---TS--------SSREPLP---
----VKRGPS---PRSG-GPSPKRSAPS---------------------------GPVH S
S--SGMEG-RAPLSHGR--DSYGG--------PPRRELPPSRRDV-----YLSPRDDAYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SSSSRDYPSSRDTRDYAPP-
PR---DYTYHDYGHSR-SCDDHP-SRGYS------DRDGYD--RDHDYS-DHPSGSSYRD
S--YESYD----------------------------------------------------
------------------------------------------------------------
-NSHSAPPKQGPPPFY----AG--NSLYHDYSS-SRDG---------YGRSEDSYSS---
-SRSDLHSSG-----RD-------------------------------------------
-YSSSCRA-PRG--GGCGG------S----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADHPGKLF--------IGGLNRETNE
----KMLKAVFGKHGPISEV-LLI----KDR-TSKS-RGFAFITFENPADAKNAAKDMNG
KSLDGKAI-KVEQAKKPSFQSDGRRRPPAS-SRNRSPSE--SLRSA---RRNSGGTR---
----------------GWLPSHEGHLD-DGGYTPDLN---MS--------YSRGLTP---
----VKRGPS---SRSG-GPPPKKSAPS---------------------------AVAR-
S -SSWMGS-QGPMSQRR--ENYGV--------PPRRGTISSWRNDRMS-----PRYDGYA
TNDGNHPSCQ-ETRDYAP---PSRGYAYRDNGHSNRDEHSSRGYRNHRSSRETRDYPPPS
RGHAYRDYGHSRRHESYSRGYRNHPSSRETRDYAPPSR-------D---YGHSRQDEHSS
RGYRYC--NFFWIYQIDF---------LYCSF---------QITL---------DYTPP-
PR---DYAYHDYGHS--SWDEHS-SRGY------SYHDGYGEALGRDHS-EHLSGSSYRD
A--FQGYG----------------------------------------------------
------------------------------------------------------------
-TSHDAPPARGPRMSY----GG--STC-HAYSN-TRDR---------YGRSWESYS----
RSCGDFHYCDH-EHVCRKDQRNPPSLGRVLPDPR-EA-----------------------
YGSSLYVA-SIV---DGGES-------------RSEKGD----SSRY-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADHPGKLF--------IGGLNRETNE
----KMLKAVFGKHGPISEV-LLI----KDR-TSKS-RGFAFITFENPADAKNAAKDMNG
KSLDGKAI-KVEQAKKPSFQSDGRRRPPAS-SRNRSPSE--SLRSA---RGSSGGTR---
----------------GWLPSHEGHLD-DGGYTPDLN---MS--------YSRGLTP---
----VKRGPS---SRSG-GPPPKKSAPS---------------------------AVAR-
S -SSWMGS-QGPMSQRR--ENYGV--------PPRRGTISSWRNDRMS-----PRYDGYA
TNDGNHPSCQ-ETRDYAP---PSRGYAYRDNVHSNRDEHSSRGYRNHRSSRETRDYAPPS
RGHAYRDCGHSRRHETYSRGYR---------DYPPPSRG--HAYHD---YGHSRRHESYC
RGYR-----------------------------------------NSPSSRETRDYTPP-
PR---DYAYHDYGHS--SWDEHS-SRGY------SYHDGYGEALGRDHS-EHLRGSSYRD
A--FQGYG----------------------------------------------------
------------------------------------------------------------
-TSHDAPPARGSRMSY----GG--STC-HAYSN-TRDR---------YGRSWESYS----
RSCGDFHYCDR-EHVCRKDQRNPPSLGGVLPDPR-EA-----------------------
YGSSLYVA-SIV---DGGES-------------RSEKGD----SSRY-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RRGPPPP-PRSRGPPR--GLRGGR-G--GSGGTR---
-----------------GPPSRGGHMD-DGGYSMNFN---MS--------SSRGPLP---
----VKRGPP---PRSG-GPPPKRSAPS---------------------------GPVR S
S--SGMGG-RAPVSRGR--DSYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYAPP-
PR---DYTYRDYGHSS-SRDDYP-SRGYS------DRDGY--GRDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGPPP----SYGG--SSRYDDYSS-SRDG---------YGGSRDSYSS---
-SRSDLYSSGR-DRVGRQERGLHPSMERGYPPP-RD-----------------------S
YSSSSRRA-PRD--GGRGG------S----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADCPEKFF--------IGGLNMET-E
----KALEAPF------VEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
NG--------------------RR--GLPPPPRTRGPSR--SLRGG---RGGSGGTR---
-----------------EPPSWGGHMD-DGGYSMHFN---MS--------SSREPLL---
----VKRGPP---PRSG-GPSPKRSAPP----------------------------KR--
SAPVHSSR-RAPLSRGR--D-----------------------NV-----YLSPRDDVSS
SR----------------------------------------------------------
------------------------------------------------------------
---------------------------------------------DYPNSCNTRDYAPP-
PG---DYTYRDYSHSS-SCDDYP-SRGY------SDRDGYDRD--HDYS-DHPSGSSYRD
S--YESYD----------------------------------------------------
------------------------------------------------------------
-NSHSAPPTQGPPPFY----AG--SSRYHDYSS-SRDG-----------------C----
GRSR---------DSYSSKRGLSPSIERGYSS-PCDS-----------------------
YSSSSCRA-PRG--GGRGGS-------------RSDRGGG---RSRY-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MMEADRPEKLF--------VGGLNLKTDE
----KALKAEFVKYGRINNM-FLM----KDRETNKS-RGFAFVTFESPADAKAAARDLNG
KYLDGKAI-KVAQAIKPAFKSSWWV---PP-PLGSSS----RWRFP---HGTRGCGS---
--------------SPQRPHSWGGPDD-GHGYVGSFD---QW--------PYRALMP---
----RKRGPP---PQRWAGPLHKRAAPS---------------------------SLAR-
SVGSEMRR-KAPAVWGR--DGYSSVPLQRWASPPRKRAAPQSSLARIGGGGMPGKA----
------------------------------------------------------------
-----------------------------------------LAMWEWEGYS---------
---------------------------------------GSPLWEPLPLCRDPGDFIPA-
LR---EYSRRYYSHSS-VRDYCP-LRGY------GKQNSYRG-HDRDYV-DHPR-GSYRE
P--LESYG----------------------------------------------------
------------------------------------------------------------
-GLCRATPGRGTPPSY----GG--GYRYEEYWG-RSPD----------------------
--------------------ALRITLPDAYSRG---------------------------
----------------RDSS-------------S--NGR----SYRYGGGGHYEEYGGPS
PDTYSGGR--------------------------------------------SPIAYSRG
RDSSSNSYSGSHRYRGGDHYEEYQGRSPEATYSGGRSPEAA-------------------
----------NSGGRSPE------------------------------------------
------------------------------AANSGGR----------HRSS--NSYGGS-
------------------------------------------------------------
-------------HHYGGGGHYEEYRGRSQDTHSGGRS----------------------
----------PDAHSGDRS------------------------------TDACSRGHD--
--------------------------------------SSSNSYGRSDHYGGGGSYQEYR
GHSHDAYSG---------------------------------------------------
----GHSPDTYSRGRD--SSSNSHDQSHRYGGGGR-YEEYGGCSPDAYGGGRD-------
-------------------------------SYGWSDRYSRGPDRVGRPDRGFPLPMERS
SPPLHDSYSWSSCRVPRGGGRQGGRLERGEGWSRY

------------------------------------------------------------
----------------------LM----KDRETNKS-RGFAFVTFESLADAKDAARDMNG
KSLDGKAI-KVEQATKPSFEGG-RRRLPPP-PRSRGPPR--GLRGGR-G--GSGGTR---
-----------------GPPSHGGHMD-DGGYSMNFN---MS--------SSRRPLL---
----MKRGPP---PRSG-GPPPKRSAPS---------------------------GLVC S
S--SGMGG-RAPVSRGR--DSYRG--------PPRREPLPSHRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRVYPSSRDTRDYAPP-
PR---DYTYHDYGHSN-SRDDYP-SRGYS------DRDGY--GRDSDYS-DHPSGGSYKD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSSPFIIFMFL----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVVADCPGKFF--------IVGLNMETNE
----KALEAPFGKYGRIV----------NSGTTKQ----------------------SLE
--------------------SG-RYGPPTL-PRSRGPPR--GLRGG---RGGSGGTR---
-----------------EPPSWGRHMD-DGGYSMHFN---TR---------TREPLP---
----VKRGPS---PRSG-GPSSKTSAPS---------------------------GPVHS
S--SGMEG-RAPLSHGR--DSYGG--------PPRRELPPSRRDV-----YLSPRDDAYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SSSSRDYPSSRDTRDYAPP-
PR---DYTYHDYGHSR-SCDGHP-SRGYS------DRDGYD--RDHDYS-DHPSGSSYRD
S--YESYD----------------------------------------------------
------------------------------------------------------------
-NSHSAPPKQGPPPFY----AG--SSLYHDYSS-SRDG---------YGRSEDSYSS---
-SRSDLHSSG-----R---D----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADHPGKLF--------IGGLNRETNE
----KMLKAVFGKHGPISEV-LLI----KDR-TSKS-RGFAFITFENPADAKNAAKDMNG
KSLHGKAI-KVEQAKKPSFQSGGRRRPPAS-SRNRSPSG--SLRSA---RGSRGGTR---
----------------GWLPSQEGHLD-DGGYTPDLK---MS--------YSRGLIP---
----VKRGPS---SRSG-GPPPKKSAPS---------------------------AVAR-
S -NSWMGS-QGPMSQRR--ENYGV--------PPRRATISSWRNDRMS-----TRHDGYA
TNDGNHPSCQ-ETRDYAP---PSRGYAYRDNGHSNRDEHSSRGYRNHRSSRETRDYAPPS
RGHAYRDYGHSRRDESYSRGYRNRRSSRETREYAPPSRG--HGYRD---YGHSRRHESYS
RGYR-----------------------------------------NHPSSRETRDYAPP-
HR---DYAYRDYGHS--SWDEHS-SRGY------SYHDGYGEALGRDHS-EHLSGSSYRD
A--LQRYG----------------------------------------------------
------------------------------------------------------------
-TSHGAPPARGPRMSY----GG--STC-HAYSN-TRDR---------YGRSWESYS----
-SCGDFHYCDR-EHVCRKDQRNPPSLGRVLPDPR-EA-----------------------
YGSSSYVA-SIV---DGGES-------------RSEKGD----SSRY-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALETVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KVRLLHPS-LARENLNFCSF----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RRGPPPP-PRSRGPPR--GLRGGR-G--GSGGTR---
-----------------GPPSRGGHMD-DGGYSMNFN---MS--------SSRGPLP---
----VKRGPP---PRSG-GPPPKRSAPS---------------------------GPVR S
S--SGMGG-RAPVSRGR--DSYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYAPP-
PR---DYTYRDYGHSS-SRDDYP-SRGYS------DRDGY--GRDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGPPP----SYGG--SSRYDDYSS-SRDG---------YGGSRDSYSS---
-SRSDLYSSGR-DRVGRQERGLPPSMERGYPPP-RD-----------------------S
YSSSSRGA-PRG--GGRGG------NRSDRG---------------GG--RSR------Y
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNLETDE
----KALEAEFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKAAARDMNG
KSLDGKAI-KVAQATKPAFESSRRGPPP---PRSRGRPR--FLRGT---RGGGGGPR---
-----------------RSPSRGGPDD-DGGYAGDFD---LR--------PSRAPMP---
----MKRGPPPP--PRRAGPPPKRAAPS---------------------------GPARS
S -GGGMRG-RALAVRGR--DGYSG--------PPRREPPPPRRDP-----YLGPRDEGYS
SRD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDY---REPRGFAPS-
PR---EYTHREYGHSS-VRDDCP-LRGYG------DRDGYG-CRDRDYG-DHPSRGSYRE
P--FESYG----------------------------------------------------
------------------------------------------------------------
-DLRGGAPGRGTPPSYG---G---GGRYEEYRG-CSP--------DAYSGGRDSYSS--S
YGRSDRYSRGR-DRVGRPDRGLSLSMERGCPPQ-RDS-----------------------
YSRSGCRV-PRG--GGRLGG-------------RMERGGG---RSRY-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADGPGKLF--------IGGLNTETNE
----KALEEVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKNAARDMNG
KSLDGKAI-KVEQATKSSFESG-RRGPPPS-PRSRGPPR--GVRGG---RGGSGGTR---
-----------------GPPSRKGHMDDDSGYSMNFN---MS--------SSRGPLP---
----GKRGPP---PRSG-CPPPKRSALS---------------------------GPVG S
S--SGMGG-RAPVSRGR--DSYGG--------PPQKEPLPS--------------HDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SNSSRDYPSSRDTTDYAPP-
PR---DYTYSDYGHSS-YR--------------------DG--DGRDYS-DHPSGGSHRD
S--CESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGPPPSY----GG--SSRYDDDGS-SRDR---------YGGSQDSYSS---
-SRSDLYSSGR-DRVDRQERGLPPSMERGTLLH-RFL-----------------------
QQFKPRKH-QEV--AAVKE------ADLIEGEAEADTRNE---QNFWTKIPSS------K
KTNK-------KWNYSVVTTQGLLKENCV-------------------------IF----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KXXXXXXX-X XXXXXXXXXXXXXXXXXXXX-XXXXXXXX--XXXXXX---XX--XXX---
-----------------XXXXXXXXXX-XXXXXXXXX---XX--------XXXXXXX---
----XXXXXX---XXXXXXXXXXXXXXX---------------------------XXXX X
X--XXXXX-XXPVSRGR--DSYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYAPP-
PR---DYTYRDYGHSS-SRDDYP-SRGYS------DRDGYG--RDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGPPPSY----GG--SSRYDDYSS-SRDG---------YGGSRDSYSS---
-SRSDLYSSGR-DRVGRQERGLPPSMERGYPPP-RDS-----------------------
YSSSSRGA-PRG--GGRGGS-------------RSDRGGG---RSRY-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------IVEADHPGKLF--------IVGLNTKTIE
----KCLETVFDKYGKIVEV-ILM----KDHETNKS-REFAFVTFESPADAKDAARDVNA
VEWKEGLWCNMEEIVMETHLEGNPCPLVEM-FISPQEMMGILLKTV---FQAQITQVLLI
QKIKHHHQEIIFTVTL-VILVHMMTTH-QEAIVIEMA---MVLILTIQIIQVEVPTEIHM
RVMV--------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNLETDE
----KALEAEFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKAAARDMNG
KSLDGKAI-KVAQATKPAFESSRRGPPP---PRSRGRPR--FLRGT---RGVGGGPR---
-----------------RSP----------------------------------------
--------------SRRAGPPPKRAAPS---------------------------GPARN
S -GGGMRG-RALALRGR--DGYSG--------PPRREPPPPRRDP-----YLGPRDEGYS
SRD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYLSRDY---REPRGFASS-
PR---EYTHREYSHSS-VRDDCP-LRGYG------DRDGYG-CRDRDYG-DHPSRGSYRE
P--FESYG----------------------------------------------------
------------------------------------------------------------
-DLRGGAPGRGTPPSYG---G---GGRYEEYRG-CSP--------DAYSGGRDSYSS--S
YGRSDRYSRGR-DRVGRPDRGLSLSMERGCPPR-RDS-----------------------
YSRSGCRV-PRG--GGRLGG-------------RMERGGG---QSRY-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEI-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RRGPPPP-PRSRGPPR--GLRG------GSGGTR---
-----------------GPPSRGGYMD-DGGYSMNFN---MS--------SSRGPLP---
----VKRGPP---PRSG-GPPPKRSTPS---------------------------GPVR S
S--SGMGG-RAPVSRGR--DSYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYAPP-
PR---DYTYRDYSHSS-SRDDYP-SRGYG------DRDGY--GRDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGPPP----SYGG--SSRYDDYSS-SRDG---------YGGSRDSYSS---
-SRSDLYSSGR-DRVGRQERGLPPSMERGYPPP-RD-----------------------S
YSSSSRGA-PRG--GGRGG------SRSDRG---------------GG--RSR------Y
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-K VEQATKPSFESG-RRGPPPP-PRSRGPPR--GLRGGR-G--GSGGTR---
-----------------GPPSRGGHMD-DGGYSMNFN---MS--------SSRGPLP---
----VKRGPP---PRSG-GPPPKRSAPS---------------------------GPVR S
S--SGMGG-RAPVSRGR--DSYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYAPP-
PR---DYTYRDYGHSS-SRDDYP-SRGYS------DRDGY--GRDRDYS-NLPSGGSYLH
S--YESYX----------------------------------------------------
------------------------------------------------------------
-XXXXXXX--XXXXXX--XYGG--SSRYDDSSS-R----------DGYGGSRDSYSS---
-SRSDLYSSGR-DRVGRQERGLPHSMERGYPPP-RD-----------------------S
YSSSSRGA-PRG--GGRGG------SRSDR---------------GGG--RSR------Y
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RRGPPPP-PRSRGPPR--GLRGGR-G---SGGTR---
-----------------GPPSRGGHMD-DGGYSMNFN---MS--------SSRGPLP---
----VKRGPP---PRSG-GPPPKRSAPS---------------------------GPVR S
S--SGMGG-RAPVSRGR--DSYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYAPP-
PR---DYTYRDYGHSS-SRDDYP-SRGYS------DRDGY--GRDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGPPP----SYGG--SSRYDDYSS-SRDG---------YGGSRDSYSS---
-SRSDLYSSGR-DRVGRQERGLPPSMERGYPPP-RD-----------------------S
YSSSSRGA-PRG--GGRGG------SRSDRG---------------GG--RSR------Y
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADHPGKLF--------IGGLNRETNE
----KTLKAVFGKHGPISEV-LLI----KDR-TSKS-RGFAFITFENPADAKNAAKDMNG
KSLDGKAI-KVEQAKKPSFQSDGRRRPPAS-SRNRSPSG--SLRSA---RGSSGGTR---
----------------GWLPSHEGHLD-DGGYTPDLK---MS--------YSRGLTP---
----VKRGPS---SRSG-GPPLKKSAPS---------------------------AVAR-
S -SSWMGS-QGPMSQRR--ENYGV--------PPRRGTISSWRNDRMS-----PRYDGYA
TNDGNHPSCQ-ETRDYAPPSPPSRGYAYRDNGHSNRDEHSSRG-RNHRSSRETRDYAPPS
RGHAYRDCGHSRQHETYSRGYRNHRSSRETRDYPPTSRG--HAYHD---YGHSRRHESYS
RGYR-----------------------------------------NSPSSQETRDYTPP-
PR---DYAYRDYGHS--SWDEHS-SRGY------SYHDGYGEALGRDHY-EHLRGSSYRD
A--FQGYG----------------------------------------------------
------------------------------------------------------------
-TSHDAPPARGPRMSY----GG--STC-HAYSN-TRDR---------YGRSWESYS----
RSCGDFHYCDR-EHVCRKDQRNPPSLGRVLPDPR-EA-----------------------
YGSSSYVA-SIV---DGGES-------------RSEKGD----SSRY-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RRGLPPP-PRSRGPPR--GLRGAR-G--GSGGTR---
-----------------GPPSRGGHMD-DGGYSMNFT---MS--------SSRGPLP---
----VKRGPP---PRSG-GPPPKRSAPS---------------------------GPVR S
S--SGMGG-RAPVSRGR--DSYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYAPP-
PR---DYTYRDYGHSS-SRDDYP-SRGYN------DRDGY--GRDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGPPP----SYGG--SSRYDDYSS-SEGFPLLSPRGGGRGGSRSDRGG---
-GRS---------RY---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RRGLPPP-PRSRGPPR--GLRGAR-G--GSGGTR---
-----------------GPPSRGGHMD-DGGYSMNFT---MS--------SSRGPLP---
----VKRGPP---PRSG-GPPPKRSAPS---------------------------GPVR S
S--SGMAG-RAPVSRGR--DSYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYVPP-
PR---DYTYRDYGHSS-SRDDYP-SRGYN------DRDGY--GRDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGPPP----SYGG--SSRYDDYSS-SRDG---------YGGSRDSYSS---
-SRSDLYSSGR-DRVGRQERGLPPSMERGYPPP-RD-----------------------S
YSSSSRGA-PRG--GGRGG------SRSDRG---------------GG--RSR------Y
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPTFETG-RRGQLPP-PRSRGPPR--GLRGGR-G--GSG-TR---
-----------------GPPSRGSH---------------LG--------SSRGPLP---
----MKRGPP---PRSG-GPPPKRPTPS---------------------------GPVR S
S--SGMGG-RAPLSRGR--DNYG---------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPNSRDTRDYAPP-
PR---DYAYRDYGHSS-SRDEYP-SRGYSSYSSYNDRDGY-GGRDRDYS-DHPSGGTYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPARGPPP----SYGG--SSRYDDYGS-ARDG---------YGGSRDSYSS---
-SRSDVYSSGR-DRVGRQDRGLPPSMERGYPPP-RD-----------------------S
YSNSSRGG-PRG--GGRGG------SRSDRG---------------GG------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVVADCLGKFF--------IVGLNTETNE
----KALEAPFGKYGRIV----------NSGTTKQ----------------------SFE
--------------------SG-RRGPPPL-PRSRGPPR--GLRGG---RGGGGGTR---
-----------------EPPSWGGLMD-DGGYSMHFN---TS--------SSREPLP---
----VKREPS---PRSG-GPSPKRSAPS---------------------------GPVHS
S--SGVEG-RAPLSHGR--DSYGG--------PPRRELLPSRRDV-----YLSPRDDVYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SSSSRDYPSSRDTREYAPP-
SR---DYTYHDYGHSS-SRDDHP-SRGYS------ERDGYD--RDHDYS-DHPSGSSYRD
S--YESYD----------------------------------------------------
------------------------------------------------------------
-NSHSAPPTQGPPPFY----AG--NSLYHDYSS-SHDG---------YGRSQDSYSS---
-SRSDLYSSG-----R---D----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RRGPPPP-PRSRGPPR--GLRGGR-G--GSGGTR---
-----------------GPPSRGGHMD-DGGYSMNFN---MS--------SSRGPLP---
----VKRGPP---PRSG-GPPPKRSAPS---------------------------GPVR S
S--SGMGG-RAPVSRGR--DSYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYAPP-
PR---DYTYRDYGHSS-SRDDYP-SRGYS------DRDGY--GRDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGPPP----SYGG--SSRYDDYSS-SRDG---------YGGSRDSYSS---
-SRSDLYSSGR-DRVGRQ------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADHPGKLF--------ICGLNRETNE
----KMLKAVFGKYGPISEV-LLI----KDR-TSKS-RGFAFITFKNPADAKNAAKDMNG
KSLDGKAI-KVEQAKKPSFQSG------AS-SRNRSPSG--SLRSA---RGSSGRTG---
----------------GWLPSHEGHLE-DGGYTPDLK---MS--------YSRGLTP---
----VKRGPS---SRSG-GPPPKKSAPS---------------------------AVAR-
S -SSWMGS-QGPMSQRR--ENYGV--------PPRRGTISSWRND-----------HGYA
TNDGNHPSCQ-ETRDYAP---PSRGYAYRDNGHSNRDEHSSRGYRNHRSSRETRDYAPPS
RGHAYCDCGHSRRHETYSRGYRNHPSSRETRDYAPPSR-------D---YGHSRQDEHSS
RGYRYC--NFFWIYQIDF---------LYCSF---------QITL---------DYTPP-
PR---DYAYRDYGHS--SWDEHS-SRGY------SYHDGYGEALGRDHS-EHLRGSSYRD
A--FQGYG----------------------------------------------------
------------------------------------------------------------
-TSHDAPPERGPRMSY----GG--STC-HAYSN-TRDR---------YGRSWESYS----
RSCGDFHYCDR-EHVCRKDQRNPPSLGRVLPDPR-EA-----------------------
YGSSSYVA-SIV---DGGEI-------------RSEKGD----SSRY-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KVRLHDE-----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPEKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKVI-K VEQATKPSFETG-RRGPPPP-PRSRGPPR--GLRGGR-G--GSGGTR---
-----------------GPPSRGGHMD-DGGYSMNFN---MS--------SSRGPLP---
----VKRGPP---PRSG-GPPAKRSAPS---------------------------GPVR S
S--SGMGG-RAPVSRGR--DSYGG--------PPRREPPPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSSDYPSS--------P-
PR---GYIYRDYGHSS-SRDDYP-SRGYS------DRDGY--GRDRNYS-DHPSGGSYRD
S--YDSYG----------------------------------------------------
------------------------------------------------------------
-NSRSAP-----------SYGG--SSRYDDYSS-SRD---------RYGGSRDSYSS---
-SQSDLYSSGR-DWVGRQDRGLPPSMGRGYPPP-RD-----------------------S
YSSSSRGA-PRG--GRRGG------SRSDRGGDR-----------------SR------Y
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLSAETNE
----KSLEAIFGKYGHIAEV-LLM----KDRETNKS-RGFAFITFENPADAKDAAKDMNG
KSLDGKTI-KVEQANKPSFESGGRRRSQPP-ARNRGNPR--NLSCGR---GGSGGAR---
-----------------GRPSRGGHLD-DGGYTLNLN---MS--------SSRGPFP---
----VKRGPT---SRSG-GPPPKRSAPS---------------------------AHGR S
S--GGMGG-RAPVSRGR--ENYGG--------PPRRETGSSRRDN-----YMSPRDDSYA
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRYTKEYAPP-
PR---DYAYRDYGHSS-SRDEHY-SRGYS------DRDGYGGGRERDYS-DHPTGGSYRD
S--YDSYG----------------------------------------------------
------------------------------------------------------------
-SSRGAPPARGPPLTY----GG--SSRYDDYST-TRDG---------YGGGRESYSS---
-SRSDSYLSGR-ERGGRQERGFPSSMDRGYPAP-RES-----------------------
YSSSGYGA-SRG---SRGGS-------------RSER-GG---RSRY-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-----MSWRFLEDREPRAFYGRASSGYNTVKMVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESGGRRGPPPP-PRSRGPPR--GLRGGR-G--GSGGAR---
-----------------GPPSRGGHMD-DSGYSLNFN---MG--------SSRGPLP---
----VKRGPP---PRSG-GPPPKRSAPS---------------------------GPVR S
S--SGMGG-RAPVSRGR--DNYGG--------PPRREPMPSRRDV-----YMSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYAPP-
PR---DYAYRDYGHSS-SRDEYP-SRGY-----S-DRDGYGGGRDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPARGPPP----SYGG--SSRYDDYSS-TRDG---------YGGSRESYSS---
-SRSDIYSSGR-DRVGRQDRGLPPSMDRGYPPP-RD-----------------------S
YSSSSRGA-PRG--GGRGG------SRSDRG---------------GG--RSR------Y
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RRGPPPP-PRSRGPPR--GLRGGR-G--GSGGTR---
-----------------GPPSRGGHMD-DGGYSMNFN---MS--------SSRGPLP---
----VKRGPP---PRSG-GPPPKRSAPS---------------------------GPVR S
S--SGMGG-RAPVSRGR--DSYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYAPP-
PR---DYTYRDYGHSS-SRDDYP-SRGYS------DRDRY--GRDRDYS-DHPGGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGPPP----SYGG--SSRCDDYSS-SRDG---------YGRSRDSYSS---
-SRSDLYSSGR-DRVGRQERGLTPSMERGYPPP-RD-----------------------S
YSSSSAEH-QAV--VAVEE------ADLIEGEAEADTRNK---QNFGP--KSQ------F
KETK-------SGSYSIITTQGLLKGKIV-------------------------LLF---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------VGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETSKS-RGFAFITFESPADAKDAARDMNG
KLLDGKSI-KVEQATKPTFESGGRRGPPPP-PRSRGPPR--GLRGGG-RGGSGGGTR---
-----------------GPPSRGGHMD-DSGYSLNFN---MG--------SSRGPLP---
----VKRGPP---PRSGGGPPPKRSAPS---------------------------GPVR S
S--SGMGG-RAPVSRGR--DNYGG--------PPRRDPMPSRRDV-----YMSPRDDGYN
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYQSSRDNRDYAPP-
PR---DYAYRDYGHSS-SRDDYQ-SRGYS------DRDGY-GGRDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPARGPPP----SYGG--SSRYDDYS---RDG---------YGGSRESYSS---
-SRSDIYSSGRGDRVGRQDRGLPPSMDRGYPPP-RD-----------------------S
YSSSSRGA-PRG---GRGG------SRSDRG---------------GG--RSR------Y
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNLETDE
----KGLEAAFGKYGRIIEV-LLM----KDRETSKS-RGFAFVTFENPADAKAAARDMNG
KSLDGKAI-KVAQATKPVFESGRRGPPP---PRSRGRPR--GLRGT---RG--GGPR---
-----------------RPPSRGGSAD-EGGYTGDFD---LR--------SSRAPMP---
----LKRGPP----PRRAGPPPKRAAPS---------------------------GPARS
--GAGIRG-RAAGSRGR--DGYGG--------PPRRELPPPRRDP-----YLGPRDEGYS
PRE---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSARDPRDFAPS-
PR---DYTYRDYGHSS-TRDECP-SRGYC------ERDGYG-GRERDY--EHPSGGSYRD
P--FDSYG----------------------------------------------------
------------------------------------------------------------
-DPRGAGPARGPPPSYG---G----GRYDEYRG-CSP--------DGYGG-RDSY-----
--RSERYSSGR-ERGGRPERGLPPSVERSCPAP-RDS-----------------------
YSRSGRRAPPRG--GGRVGS-------------RLERGGG---RSRY-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNPETDE
----KALEAAFGKYGSIVEV-LLV----KDRETTKS-RGFAFITFESPADAKAAARDMNG
KSLDGKTI-K VAQATKSAFESGRRGRGL--------RVV--Q---------GGGGPR---
-----------------RLPSRGEPAY-DGDL---------R--------PSR-------
----------------A-PMPVKRAAPS---------------------------GPA-R
S SGGGMRG-RAPVARGR--DGYAG--------PPRREPGPPRRDP-----YLGPREEGYS
PRDS--------------------------------------------------------
-------------------------------------------------YS---------
-------------------------------------------SRDYLSGRDPRDFAPS-
PR---EYTYRDYGHSS-ARDDCP-SRCY------SDRDGYGGRD-RDYA-DHPSGGSYRD
F--VESYG----------------------------------------------------
------------------------------------------------------------
-A------------SY----GG--GGRYEEYRGCSPDP---------YGGGRDSYT----
SGRSDRYSRGR-ERVGRPDRGLPPSMERGCPP--RDS-----------------------
YSRSARRA-PRV--GGRLGN-------------RRERGGG---RSRY-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KAFEAVFGK-------------------------GFAFVTFESLADAKDAARDMNG
KSLDGKAI-KVEQATKPSFEGG-RRRLPPP-PRSRGPPR--GLRGG---RGGSGGTR---
-----------------GPPSHGGHMD-DGGYSMNFN---M-------------------
------------------------------------------------------------
-------------------------------------------NV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRVYPSSRDSRDYAPP-
PR---DYTYRDYGHSS-SRDDYP-SRGYS------DRDGYG--RDSDYS-DHPSGGSYKD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGPPPS----HGG--SSRYDDY-----NG---------YGGSRDSYSS---
-SRSDLYSSGR-DRVGRQERGPSPSMERGYPPP-HDS-----------------------
YSSSSLGA-PRG--GGLGG------S-------RSDRGGG---RSRY-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADHPGKLF--------IGGLNRETNE
----KMLKAVFGKHGPISEV-LLI----KDR-TSKS-RGFAFITFENPADAKNAAKDMNG
KSLDGKAI-KVEQAKKPSFQSDCRRRPPAS-SRNRSPSG--SLRSA---GGSSGGTR---
----------------GWLPSHEGHLD-DGGYTPDLN---MS--------YSRGLTP---
----VKRGPS---SRSG-GPPPKKSAPS---------------------------AVAR-
S -SSWMGS-QGPMSQRR--ENYGV--------PPRRGTISSWRNDRMS-----PRYDGYA
TNDGNHPSCQ-ETRDYAP---PSRGYAYRDNGHSNRDEHSSRGYRNHRSSRETRDYPPPS
RGHAYRDYGHSRRHESYSRGYRNHPSSQETRDYAPPSR-------D---YGHSRQDEHSS
RGYRYC--NFFWIYQIDF---------LYCSF---------QITL---------DYTPP-
PR---DYAYCDYGHS--SWDEHS-SRGY------SYHDGYGEALGRDHS-EHLSGSSYRD
A--FQGYG----------------------------------------------------
------------------------------------------------------------
-TSHDAPPARGPRMSY----GG--STC-HAYSN-TRDR---------YGRSWESYS----
RSCGDFHYCDR-EHVCRKDQRNPPSLGRVLPDPR-EA-----------------------
YGSSLYVA-SIV---DGGES-------------RSEKGD----SSRY-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RRGPPPP-PRSRGPPR--GLRGGR-G--GSGGTR---
-----------------GPPSRGGHMG-NNLRGPRVW---CN------------------
-------------KLGT-ASSHQRSAPS---------------------------GPVG S
S--SGMGG-RAPVSRGR--DSYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYAPP-
PR---DYTYRDYGHSS-SRDDYP-SRGYS------DRDGY--GRDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGPPP----SYGG--SSRYDDYSS-SRDG---------YGGSRDSYSS---
-SRSDLYSSGR-DRVGRQERGLPPSMERGYPPP-RD-----------------------S
YSSSSRGA-PRG--GGRGG------SRSDRG---------------GG--RSR------Y
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RRGPPPP-PRSRGPPR--GLRGGR-G--GSGGTR---
-----------------GPPSLGGHID-DGGYSMNFN---MS--------SSRGPLP---
----VKRGPP---PRSG-GPPPKRSAPS---------------------------GPVR S
S--SGMGG-RAPVSRGR--DSYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSGDTRDYAPP-
PR---DYTYRDYGHSS-SRDDYP-SRGCS------DRDGY--GRDRDYS-DHPSGGSYRD
S--HESYG----------------------------------------------------
------------------------------------------------------------
-LLKGKVVLHFLNSLL--S---------SPS-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------VGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETSKS-RGFAFITFESPADAKDAARDMNG
KLLDGKSI-K VEQATKPTFESGGRRGPPPP-PRSRGPPR--GLRGRGR-GGSGGGTW---
-----------------APPSRGGHLD-DSGYSLNFN---MG--------SSRGPLP---
----VKRGPP---PRSGGGPPPKRSLPS---------------------------GPVR S
S--TGMGG-RAPASRGR--DSYGG--------PPRRDPMPSRRDV-----YMSPRDDGYN
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDNRDYAPP-
PR---DYAYRDYGHSS-SRDDYP-SRGYS------DRDGYG-GRDRDYA-DHPSGGFYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPARGPQPSY----GG--SSRYDDYS---RDR---------YGGSRESYSS---
-SRSDIYSSGRGDRVGRQERGLPPSMDRVYPPP-RDS-----------------------
YSSSSRRA-PRG---GRGGS-------------RSDRGRG---RSRY-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MAETNQPGKIF--------IGGLNIKTRQ
----KTLQEIFGRFGPVARV-ILM----RDRETKKS-RGFAFLTFRRLADAKNAVKEMNG
VILDGKRI-KVKQARRPSSLESGSKKR-PP-S-FSRTRG--ASRIL---KCGRGGRS---
--------------RARSGPSCEGNLG-GDRYTPNFN---VS--------SSGRHFA---
----VKRNPS---SKRD-DPPSKR------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KVRLSTQW-MITCY----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-K VEQATKPSFESGGRRGPPPP-PRSRGPPR--GLRGGR-G--GS-GAR---
-----------------GPPSRGSHL---------------G--------SSRGPLP---
----MKRGPP---PRSG-GPPPKRSAPS---------------------------GPV RS
S---SMGG-RAPVSRGR--DSYGG--------PPRREPMPSRRDV-----YMSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------GYSSRDYPSSRDTRDYAPP-
PR---DYAYRDYGHSS-SRDEYP-SRGYSLSSYS-DRDGYGGGRDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPARGPPP----SYGG--SSRYDDYGS-TRDG---------YG-SRESYSS---
-SRSDVYSSGR-DRVGRQDRGLPPSMERGYPPP-RD-----------------------S
YSSSSRGA-PRG--GGRGG------SRSDRG---------------GG--RSR------Y
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVVADCPGKFF--------IVGLNMETNE
----KALEAPFGKYGRIV----------NSGTTKQ----------------------SLE
--------------------SG-RRGPPTL-PRSRGPPR--GLRGG---RGGSGGTR---
-----------------EPPSWGGHMD-DGGYSMHFN---IS--------SSREPLP---
----VKRGPS---PRSG-GPSPKRSAPS---------------------------GPVHS
S--SGMEG-RAPLSHER--DSYGG--------PPRRELLPSRRDV-----YLSPRDDEYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SSSSRDYPSSRDTRDYAPT-
PR---DYTYHDYAHSR-SCDDHP-SRGYS------DRDGYD--HDHDYS-DHPSGSSYRD
S--YESYD----------------------------------------------------
------------------------------------------------------------
-NSHSAPPKQGPPPFY----AG--SSLYHDYSS-SRDG---------YGRSEDSYSS---
-SRSDLHSSG-----R---D----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEVDRPGKLF--------IGGLNLETDE
----KILEATFGKYGCLTEV-LLM----KDRETSKS-RGFAFVTFESPADAKAAARDMNG
KTLDGKAI-K VAQATKPAFESSRRGPPPSH---SRPRGL--LG-------DRGSGPR---
-----------------RPQXXXXXXX-XXXX---------X--------XXXXXXXXXX
XXXXXXXXXX---XXXX-XXXXXXXXXX---------------------------XXX-X
X XXXXXXX-XXXXXXGR--DGYAG--------PVRREPPPPRRDP-----YLGPREEGYS
PRDS--------------------------------------------------------
-------------------------------------------------YS---------
------------------------------------------SSRDYSSARDPRGFAPS-
PR---EYTYRDYGHSS-ARDDCP-SRGY------GERDGYGGRD-RDYL-YHPSGGSYRD
P--FESYG----------------------------------------------------
------------------------------------------------------------
-DPRSAAPSRGPPPSY----GG---GRYDEYRGCPPDA---------YGGGRSERY----
W-------RGR-DRAGRADRGRLRSMERGCPP-PRES-----------------------
YSGSGRRA-PLG--GGRLGS-------------CAERGGD---RSRY-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNPETDE
----KALETAFGKYGRISEV-LLM----KDRETAKS-RGFAFVTFESPADAKAAARDMNG
KVQVSIPE-GGW-----LFHI---------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RRGPPPP-PRSRGPPR--GLRGGR-G--GSGGTR---
-----------------GPPSRGGHMD-DGGYSMNFN---MS--------SSRGPLP---
----VKRGPP---PRSG-GPPPKRSAPS---------------------------GPVR S
S--SGMGG-RAPVSRGR--DSYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYAPP-
PR---DYTYRDYGHSS-SRDDYP-SRGYS------DRDGY--GRDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGPPP----SYGG--SSRYDDYSS-SRDG---------YGGSRDSYSS---
-SRSDLYSSGR-DRVGRQERGLPPSMERGYPPP-RD-----------------------S
YSSSSRGA-PRG--GGRGG------SRSDRG---------------GG--RSR------Y
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNLETDE
----KGLETAFGKYGRIIEV-LLM----KDRETSKS-RGFAFVTFENPADAKAAARDMNG
KSLDGKAI-KVAQATKPVFESGRRGPPP---PRSRGRPR--GLRGT---RG--GGPR---
-----------------RPPSRGGSAD-EGGYTGDFD---LR--------PSRAPMP---
----LKRGPP----PRRAGPPPKRAAPS---------------------------GPARS
--GAGIRG-RAAGSRGR--DGYGG--------PPRRELPPPRRDP-----YLGPRDEGYS
PRE---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSARDPRDFAPS-
PR---DYTYRDYGHSS-ARDECP-SRGYC------ERDGYG-GRERDY--EHPSGGSYRD
P--FDSYG----------------------------------------------------
------------------------------------------------------------
-DPRGAGPARGPPPSYG---G----GRYDEYRG-CSP--------DGYGG-RDSY-----
--RSERYSSGR-ERVGRPERGLPPSVERNCPAP-RDS-----------------------
YSRSGRRAPPRG--GGRVGS-------------RLERGGG---RSRY-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKDI--PYES----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNLETDE
----KALEAEFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKAAARDMNG
KSLDGKAI-KVAQATKPAFESSRRGPPP---PRSRGRPR--FLRGT---RGGGGGPR---
-----------------RSPSRGGPDD-DGGYAGDFD---LR--------PSRAPMP---
----MKRGPPPP--PRRAGPPPKRAAPS---------------------------GPARS
S -GGGMRG-RALAVRGR--DGYSG--------PPRREPPPPRRDP-----YLGPRDEGYS
SRD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------GYSSRDY---REPRGFAPS-
PR---EYTHREYGHSS-VRDDCP-LRGYG------DRDGYG-CRDRDYG-DHPSRGSYRE
P--FESYG----------------------------------------------------
------------------------------------------------------------
-DLRGGAPGRGTPPSYG---G---GGRYEEYRG-CSP--------DAYSGGRDSYSS--S
YGRSDRYSRGR-DRVGRPDRGLSLSMERGCPPQ-RDS-----------------------
YSRSGCRV-PRG--GGRLGG-------------RMERGGG---RSRY-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MMEADRPEKLF--------VGGLNLETDE
----KALEAEFVKYGRIINV-FLI----KDRETNKS-RGFAFVTFESPADAKAAARDLNG
KYLDGKAI-KVAQATKPAFESSRRGPPPPH---SRGRPR--FLRGT---RGGGGGPR---
-----------------RSPSRGGPDD-DGGYAGDFD---LR--------PSRAPMPMKR
G-----PP-P---PRRA-GPPPKRAAPS---------------------------GPARS
-SGGGMRG-RALAVRGR--DGYSG--------PPRREPPPPRRVP-----YLGPRDEGYS
SRDS--------------------------------------------------------
-------------------------------------------------YS---------
-------------------------------------------RRDY---REPRGFAPS-
PR---EYTHREYGHSS-VRDDCP-LRGY------GDRDGYGCRD-RDYG-DHPSRGSYRE
P--FESYG----------------------------------------------------
------------------------------------------------------------
-DLRGGAPGRGTPPSY----GG-GGGRYKEYLGSSPDA---------YGGGRNSSSN--S
YGRSDSYSRGR-DRVGRPDLGLPLPMERSSPH-LHDS-----------------------
YSRSSCRV-PRG--GGHQGS-------------RLEKGEG---WSRY-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

--------------------------------------GKLF--------IGGLNTETNE
----KALEAIF------VEV-LSM----KDRETNKS-REFAFVTFESPADAKDAARDVNG
KSLDGKAI-KVEQATKPSFGRG-RRGPPPP-PRSRGPPR--ALRGG---RGGSGGTR---
-----------------GPPSRGGHMD-DGGYSMDFN---MS--------SSRAPLP---
----VKRGPP---PRSG----------------------------------------VR S
S--SGMGG-RAAVSRGR--NSCGG--------PPQREPLPSRRDV-----YLSPRDDGDS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDDAPP-
PR---DYIYRDYGRSS-SRDDYP-SRGDS------DRDGYG--RDRDYS-DHPGGGSYRD
P--YGSYG----------------------------------------------------
------------------------------------------------------------
-NSRNAPPTGGPPPSMVEAVAV--MITAAHVT-------------------DMVEVE---
-TVTQAAEVIS-TRVGRQEGGLPPSMEREYPPP-HDS-----------------------
YSSSSPGA-PRG--GGRGG------S-------RSDRGGG---RSRY-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

--------------------------------VEADRPGKVF--------VGGLSTETNK
----KALEAVFGKYGRIVEA-LLR----KDHETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RRGLPPP-PRSRGPPR--GLRGG---RGGR-------
------------------EPSRGRHMD-DGGYSMNFN---MS--------SSRGPLP---
----VKRGSP---LRSG-SPPPKTSAPS---------------------------GPVC S
S--SGMGG-RAPVSRGR--DSYGD--------PPRREQLPSGRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYPSRDYPSSCDTRDYAPP-
PR---DYTYCDYGHFS-SHGDYP-SRGYS------DRDGYS--RDC----------SYRD
S--HESYG----------------------------------------------------
------------------------------------------------------------
-NSGSAPPTRGPPCGY------------DDYSS-SPDR---------Y----DSYSS---
-SQSDLYSSGG-DQVGRQERG--CGALRGGGHG-GS--QSDRGGGRSR---Y--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADHTRKLF--------IGGLNMETNE
----KALEEVF------VEV-FLM----KDYETNKS-RGISFVTFESSTDAKDAARDMNG
KSLHGKAI-KVEQATKPSFESGRC--GPSPLPRSRGPPR--GLRGG---RGGSEGTR---
-----------------RPLLWGGHMD-DGGYSMNFN---MS--------SSRGPFP---
----RSAP-S---GR------------------------------------------V--
H SSSGKGG-RAPISRGR--DSYG-------------ELLPSHRDV-----YLSPGDDGWY
ST----------------------------------------------------------
------------------------------------------------------------
---------------------------------------------KAS--YSSID-----
YL---NYIYRDYGQGY----------SN------SNRDVYGCD--RDYS-DHSSG-----
------------------------------------------------------------
------------------------------------------------------------
---GGAPPTRGPPPSY----GG--HYSY---------------------------S----
SSRSDLCLGGH-DWIGRQERGLPPSMERGYPP-PCDS-----------------------
YSSSSCGA-PRG--GSIGGS-------------PSDRGGG---RSRY-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RRGPPPP-PRSRGPPR--GLRGGR-G--GSGGIR---
-----------------GPPSHGGHMD-DGSYSMNFN---MS--------SSRGPLP---
----VKRGPP---PRSG-GPPPKRSAPS---------------------------GPVR S
S--SGMGG-RAPVSRGR--DSYGG--------PPRRETLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDSRDYAPP-
PR---DYTYRDYGHSS-SRDDYP-SRGYS------DRDGY--GRDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGPPP----SYGG--SSRYDDYSS-SRDR---------YGGSRDSYSS---
-SRSDLYSSGR-DRVGRQERALPPSMERGYPPP-HD-----------------------S
YSSSSRGA-PRG--GGRGG------SRSDRG---------------GG--RSR------Y
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MMEADRPEKLF--------VGGLNLKTDE
----KALKAEFVKYGRIINV-LLM----KDRETNKS-RGFAFVTFESPADAEAAARDLNG
KYLDGKAI-KVAGAIKPAFKSSRWG---PP-PPGSSS----RSRFP---HGTRGCGS---
--------------SPQRPHSWGGPDD-GHGYAGYFD---QW--------PYRAPMP---
----RKRGPP---PQRWASPLRKRAAPS---------------------------SLAR-
SVGSGMRG-KAPAVWGR--DGYSSVQLQRWAGPPRKRAAPPSSLARIGSGGMPGKA----
------------------------------------------------------------
-----------------------------------------PAMWGREGYS---------
---------------------------------------GPLLREPLPRCRDPGDFIAA-
LR---EYSRRYYSHSS-VRDYCP-LRGY------GKQNSYRG-RDHDYV-DHPSRGSYRE
P--LESYR----------------------------------------------------
------------------------------------------------------------
-GPCRATPGRGTPPSY----GG--GYRYEGYRG-RSPD----------------------
--------------------ALPVTLPDAYSGG---------------------------
----------------HDSS-------------S--NGR----SDRYGGRGHYEEYGGPS
PDTYSGG-----------------------------------------------------
RDSSINSYSWSHRYRGGGHYEEYQGRSPQAANSGGRSPEAA-------------------
----------YSG-----------------------------------------------
-----------------------------------GRSPEAAYSGGRSPEA--AYSG---
------------------------------------------------------------
-----------------------------------GRSP---------------------
------------------------------------------------------------
-------------------EAAYSGGRSPEAAYSGGRHSSSNSYSGSQRYGGGGHYEEYR
GCSQDTHSGGRSPDTHSGGRNPSAHTGGH-SPDAHSGDRSTDACSRGHDSSSNSYGGGSY
EEYRGHSPDTYSRG----------------------------RSPDAYGGGHDSSINSYG
LSDRYAGGGRYKEYLGSSPDAYGGGRNSSSNSYGQSDSYSRGRDRVGTPDLGLPLPMERS
SPPLHDSYSRSSCRVPRGGGCQGGRLERGEGWSRY

------------------------------------------------------------
------------------------------------------------------------
-----------K----PSFENGRH--GPLLSARSRGL-S--RFRGR---KGGSGGTR---
----------------------GGHMD-DGGYSMNFN---MS--------FSRGPLP---
----AKRGPP---PKSG-GPPPKRSAQS---------------------------GSL--
CSSSGMGR-RAPLSQGR--DSYGS--------PQRTEPLPSQTDV-----YLSPRDDGYS
TKDC--------------------------------------------------------
-------------------------------------------------YS---------
------------------------------------------SRSYPS--SHDRDYEPP-
PR---DYTYRDYGHSS-SCDDCP-SRGY------NDRDGYGCD--QEYS-DHPRGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-DSHS-PTWGRPPPSY----GG--SSCYGDYRS-SCDI---------YGRSRDSSS----
SSQSDLYSSGH-DWTDRPKRGFPPE-ERVSPP-PHDS-----------------------
YSIPNHGV-LRC--GGHEGS-------------QSDKGEA---EEDA-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADHPGKLF--------TGGLNTETNK
----KVLEAAFGKYGQIVKV-LL------------------FVTFENPAATKDAARDMNK
KSLDGKAI-KVKQATKLSFESG-RHGPPPP-PRSRGPPR--GLRGG---RGGSEETR---
-----------------GPPSWGGHMN-DSGYSTNFN---TS--------SSRVPLP---
----VKRRPP---PRSG-GPPPKTAAPS---------------------------GPVCS
S--SGMGG-RAPVSRGR--DN-----------------------------------DGSS
TRD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSSDYPSSRDTRDYAPP-
PR---DYTYRDYGHSS-SSDDYP-SRGYS------NRNGYG--RDRDSS-DHPSGEPP--
------------------------------------------------------------
------------------------------------------------------------
-------------PS-----YG--GSSYDDYSS-SRDR---------YGGSRDSYSS---
-SRSDLYLSGH-DQAGRQERGLPPSMEKGYPPP-HDS-----------------------
CSSSSRRT-PRG--GGCEG------S-------RSDRGGG---RNRY-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEI-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFR----------------------------G--GSGGTR---
-----------------GPPSRGGYMD-DGGYSMNFN---MS--------SSRGPLP---
----VKRGPP---PRSG-GPPPKRSTPS---------------------------GPVR S
S--SGMGG-RTPVSRGR--DSYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYAPP-
PR---DYTYRDYSHSS-SRDDYP-SRGYG------DRDGY--GRDREYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGPPP----SYGG--SSRYDDYSS-SRDG---------YGGSRDSYSS---
-SRSDLYSSGR-DRVGRQERGLPPSMERGYPPP-RD-----------------------S
YSSSSRGA-PRG--GGRGG------SRSDRG---------------GG--RSR------Y
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNLETDE
----KALEAAFGKYGRIIEV-LLM----KDRETSKS-RGFAFVTFENPADAKAAARDMNG
NVPMVDLGIVMISIPNSEVLVQVEKIGLLP----LG------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFETS-RRGLPPP-PRSRGPPR--GLRGGR-G--GSGGTR---
-----------------GPPSRGGHMD-DGGYSMNFT---MS--------SSRGPLP---
----VKRGPP---PRSG-GPPPKRSAPS---------------------------GPVR S
S--SGMAG-RAPVSRGR--DSYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYAPP-
PR---DYTYRDYGHSS-SRDDYP-SRGYG------DRDGY--GRDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGPPP----SYGG--SSRYDDYSS-SRDG---------YGGSRDSYSS---
-SRSDLYSSGR-DRVGRQERGLPPSMERGYPPP-RD-----------------------S
YSSSSRGA-PRG--GGRGG------SRSDRG---------------GG--RSR------Y
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RRGPPPP-PRSRGPPR--GLRGGR-G--GSGGTR---
-----------------GPPSRGGHMD-DGGYSMNFN---MS--------SSRGPLP---
----VKRGPP---PRSG-GPPPKRSAPS---------------------------GPVR S
S--SGMGG-RAPVSRGR--DSYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYAPP-
PR---DYTYRDYGHSS-SRDDYP-SRGYS------DRDGY--GRDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGPPP----SYGG--SSRYDDYSS-SRDG---------YGGSRDSYSS---
-SRSDLYSSGR-DRVGRQDRGLPPSMERGYPPP-RD-----------------------S
YSSSSRGA-PRG--GGRGG------SRSDRG---------------GG--RSR------Y
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEI-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RRGPPPP-PRSRGPPR--GLRG------GSGGTR---
-----------------GPPSRGGYMD-DGGYSMNFN---MS--------SSRGPLP---
----VKRGPP---PRSG-GPPPKRSTPS---------------------------GPVR S
S--SGMGG-RAPVSRGR--DSYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYAPP-
PR---DYTYRDYSHSS-SRDDYP-SRGYG------DRDGY--GRDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGPPP----SYGG--SSRYDDYSS-SRDG---------YGGSRDSYSS---
-SRSDLYSSGR-DRVGRQERGLPPSMERGYPPP-RD-----------------------S
YSSSSRGA-PRG--GGRGG------SRSDRG---------------GG--RSR------Y
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------VVEVDRPGKLF--------I---------
-------------------------------ETNKS-RGFAFVTFESPADAKDAAWNMNG
KSLDGKA M-KVEQATKPSFESG-RRGPPPP-PSSRGPPR--GPRGG---RGGSGGTR---
-----------------GPPSHGEHMD-DGGYSMNFN---MS--------SSRGPLP---
----MKRGSP---PRSG-E-------------------------------------PVH S
S--SGMDG-RAPVSLGR--DSYGG--------PPQREPLPSRRDV-----YLSPRDDGYS
IKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSHDTR------
-----DYTYRDYGHSS-SRDDYP-SRGYS------DRDGYG--WDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGK-------------------------GFAFVTFESPVDAKDAAQDMNG
KSLNGKAI-KVEQATKPSFEGG-RLRPPPP-PRSRGPPR--GLRGG---RGGSGGNR---
-----------------GPPSYGGHMD-DGGYSMNFN---MS--------SSRGPLP---
----VKRGPP---PRSE-GPPPKRSAPS---------------------------GPVR S
S--SGMRG-RAPVSRGR--DSY--------------------RDV-----YLSPRDYGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYF-----------NYTPP-
PR---DYTYRDYGHSS-SRDDYP-SRGYS------DRDGYG--RDRDYS-DHPSYGN---
------------------------------------------------------------
------------------------------------------------------------
--SRSAPPT---------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MMEADRPEKLF--------IGGLNLKTDE
----KALKAEFGKYGHIIKV-FLM----KDRKTNKS-RGFAFVTFESPADAKAAARDMNG
KYLDGKAI-MVAQTIKPAFKSSRWV---PP-TPGSGS----RSRFS---HRTRGGGS---
--------------SPQRPPSQGRPDD-GRGYAGYFD---LW--------PYRAPMP---
----RKRGPP---PRHWASPPHKRATPS---------------------------SLAH-
SVGCGMRG-KAPTVSGQ--DGYSGLQPRRWAGPPHKRAVPRSSLARIGGSGMPGKA----
------------------------------------------------------------
-----------------------------------------PAVWGQDGYS---------
---------------------------------------GPRVREPLPPCRDPGDFVPA-
LR---DYSRRYYGHSS-VPDYRP-LRGD------GNQNGYRG-RDHEYT-DHPSKGSYRE
P--LKSYG----------------------------------------------------
------------------------------------------------------------
-GPCGAAPVWGTPPSY----GG--GCRYEEYQG-NSPD---------ACSEGRSS-----
-------------------EALPVVLPDAYSRD---------------------------
--HSP-KA-YSG---GRSSS-------------SNGYSR----SDRYGEEGCYEEYRGRS
PDAHSGGRNSSSNSYGQSHHYGG-EGRYEEYRGRSHEARSGGRSTDAHSRGRSDDAYSGG
H----DSSSWSDCCGGGGRYEEYQGRSLDANS-GGCSPEAYSGGHDNSSWSDRYGVGGHY
EENRGHSLDANSGGRSPDTHSGGHSSSSNSYGQSHRYGGEGRYEYRGRSHDAHSGGCSAD
AYSGGHDSSSQSNRY-GGGGCYEEYRGRSLDANSGGRSPNA-YSGGHDSSSWSHRYGGGG
RYEEYRGRSLDANSGGRSPDAYSGGHDSSGQSNCYGGGGRYEEYRGRLLDANSGGRSPDA
--YSGGHDSSSQSNRYGGGGRYEEYRGHSLDANSGGRSPDTYSRGHDSSSQSDHYGGGGR
SLDANSSGRLPDAYSGGHDSSSRSHRYGGGGRYEEYRGRSLDANSGGRSPNAYSGGHNSS
SRNDPCRGGGRYEENRGHSLDANSGGH-SPNAYSGGRDSSSNSYDRSHRYGGGGHYEEYR
GRSHDTHSRGRSPDAHSGDHYTEAYSRGRDSFSN------------SYGRSDHYGRGGCY
EEYQGRSPNAYGGGRGLNSSNNSHGRSHRYGGGGR-YEEYRGPSPDAHSGGRDSSIKSYG
LSDRYGGGGHYEEYQGSLPDAYSGDHDRSSNSYGRSDRYSRGRDRVGRPDRGLPLPMETG
SPPLHDSYSRSGCRVPRGGGRQGGRFERGEGRSRY

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEI-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RRGPPPP-PRSRGPPR--GLRG------GSGGTR---
-----------------GPPSRGGYMD-DGGYSMNFN---MS--------SSRGPLP---
----VKRGPP---PRSG-GPPPKRSTPS---------------------------GPVR S
S--SGMGG-RTPVSRGR--DSYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYAPP-
PR---DYTYRDYSHSS-SRDDYP-SRGYG------DRDGY--GRDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGPPP----SYGG--SSRYDDYSS-SRDG---------YGGSRDSYSS---
-SRSDLYSSGR-DRVGRQERGLPPSMERGYPPP-RD-----------------------S
YSSSSRGA-PRG--GGRGG------SRSDRG---------------GG--RSR------Y
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNLETDE
----KALEAEFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKAAARDMNG
KSLDGKAI-KVAQATKPAFESSRRGPPP---PRSRGRPR--FLRGT---RGGGGGPR---
-----------------RSPSRGGPDD-DGGYAGDFD---LR--------PSRAPMP---
----MKRGPP----PRRVGPPPKRAAPS---------------------------GPARS
S -GGGMRG-RALAVRGR--DGYSG--------PPRREPLPPRRDP-----YLGPRDEGYS
SRD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------GYSSRDY---REPRGFAPS-
PR---EYTHRDYGHSS-VRDDCP-LRGYS------DRDGYG-GRDRDYG-DHLSRGSYRE
P--FESYG----------------------------------------------------
------------------------------------------------------------
-DLRGAAPGRGTPPSYG---G---GGRYEEYRG-CSP--------DAYSGGRDSYSS--S
YGRSDRYSRGR-HRVGRPDRGLSLSMERGCPPQ-RDS-----------------------
YSRSGCRV-PRG--RGRLGG-------------RLERGGG---RSRY-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADCPGKLF--------IGGLNRETNE
----KMLKAVFVKHGPISEV-LLI----KDR-TSKS-RGFAFITFENPADAKNAAKDMNG
KSLDGKAI-KVEQAKKPSFQSGGRRRPPPS-SRNRSPSG--SLRSA---KGSSGGTR---
----------------GWHPSHEGHLD-DGEYTLDLN---MS--------SSRGAIP---
----VKRGPS---SRSG-GPLPKKSALS---------------------------AMAR-
S-NSWIRS-QGKCYLTE--RLIMEVL--HAESQPLPGEMTICHEEMMV--MQLRRGKGKM
KKHN--------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RRGPPPP-PRSRGPPR--GLRGGR-G--GSGGTR---
-----------------GPPSRGGHMD-DGGYSMNFN---MS--------SSRGPLP---
----VKRGPP---PRSG-GPPPKRSAPS---------------------------GPVR S
S--SGMGG-RAPVSRGR--DSYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYAPP-
PR---DYTYRDYGHSS-SRDDYP-SRGYS------DRDGY--GRDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGPPP----SYGG--SSRYDDYSS-SRDG---------YGGSRDSYSS---
-SRSDLYSSGR-DRVGRQERGLPPSMERGYPPP-RD-----------------------S
YSSSSRGA-PRG--GGRGG------SRSDRG---------------GG--RSR------Y
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

------------------------------MIEADC-PAKFF------------------
-----------------------------IGETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RRGPPPP-PRSRGPPK--GLRGG---RGRSGGTR---
-----------------GPPSWRRHMD-D-------------------------------
----IKRGPP---PRSG-GPPPKRSAPS---------------------------GPVR S
S--SGMGG-RAPVSR-------CG--------PPGREPLPSRRDV-----YLPPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SSSSRDYPSSRDTRGYAPPP
PR---DCTYRDYGHFN-SRDDYP-SRGYS------DRDGYN--SDHDYS-DHPTGDSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSSSDMNSSFFMA------------------A---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFITFENPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RRVPPPP-PRSRGPPR--GLRGGR-G--GSGGTR---
-----------------GPPPRGGHMD-DGGYSMNFN---MS--------SSRGPLP---
----VKRGPP---PRSG-GPPPKRSAPS---------------------------GPVR S
S--SGMGG-RAPVSRGR--DSYGG--------PPRREPLPSRRDL-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYAPP-
PR---DYTYRDYGHSS-SRDDYP-SRGYS------DRDGY--GRDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-I----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RRGPPPP-PRSRGPPR--GLRGGR-G--GSGGTR---
-----------------GPPSRGGHMD-DGGYSMNFN---MS--------SSRGPLP---
----VKRGPP---PRSG-GPPPKRSAPS---------------------------GPVR S
S--SGMGG-RAPVSRGR--DSYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYAPP-
PR---DYTYRDYGHSS-SRDDYP-SRGYS------DRDGY--GRDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGPPP----SYGG--SSRYDDYSS-SRDG---------YGGSRDSYSS---
-SRSDLYSSGR-DRVGRQDRGLPPSMERGYPPP-RD-----------------------S
YSSSSRGA-PRG--GGRGG------SRSDRG---------------GG--RSR------Y
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MAEAYHTRKLF--------IGGLNTETNE
----KALEEV------FVEI-LLM----KDYETNKS-RGISFVTFESSTDAKDAARDMNR
KSLHGKTI-KVEQATKPSIESG-RCGPSPL-PRSRGPPR--GLRGR---RGESEGTR---
-----------------RPLSWGGHMD-DGGYSMNFN---MS--------SSRRPLP---
----VKRGPP---PISG-GPPPKRSAPS---------------------------GQVH S
S--SGKGG-RAPVSRGR--DK----------------LLPSHRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------GYSSIDYLSFHDTRDYAPP-
PR---DYIYCDYGHNS-NRD------------------GYG--CDHDYS-DHSGG-----
------------------------------------------------------------
------------------------------------------------------------
---GGAPPTRGPPPSY----GG--HCCYDDYRS-SHDG---------YGGSRDSYLS---
-SRSDPYLGGH-DRVGRQERGLPSSMERGYPPP-CDS-----------------------
YSSSSCGA-PRG--GGSGG------S-------PSDREGG---RSRC-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNHETDE
----KSLEAAFGKYGHISEV-LLM----KDRETNKS-RGFAFITFESPADAKAAVRDMNG
KSLDGKAI-KVAQATKPAFESGRRGPPL---SRSRGRSR--GLRGA---RG--GGPR---
-----------------RPPSRGGPAD-DGGYAGDFD---LR--------PSRAPLP---
----MKRGPPP---PRRAGPPPKRAAPS---------------------------GPARS
GG GGGMRG-RAPAARGR--DGYEG--------PPRREPPPPRRDP-----YLGSREGGYS
PRD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------GYSSRDYPSARDARDFAPS-
PR---EYTYRDYGHSS-ARDECP-SRGYG------DRDGYG-GRDRDYA-DHPSGGSYRD
P--FESYG----------------------------------------------------
------------------------------------------------------------
-DPRSAAPARGPPPSYG---GG--GGRYEEYRG-CSP--------DAYGGGRDGYAG---
-GRSERYSGGR-DRVGRADRGLPQSVERGCPPP-RES-----------------------
YSRSGRKV-PRG--GGRLGS-------------RSERGGG---G-RSRY-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

---------------------------------MSDRPGKFF--------IDGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-REFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RHGPPPP-PKSRGPPR--GIRGG---RGGSRGTR---
-----------------GPSSRGRHMD-DGGFSMDFN---MS--------SSRRTRE---
----VKRGP----PRSG-GPPPKRSAPS---------------------------GPVR S
S--SGMGG-RAPVSRGR--DSYGG--------PPRREPLPSRRDV-----HLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYAPP-
PR---DYTYRDYGHSS-SRDDYP-SRGYG------DRDGCG--RDGDYS-DHPSGGSHRD
S--HESCG----------------------------------------------------
------------------------------------------------------------
-SSRSAPPTGAP--------------------G-SPDG---------YGGSRDSCSS---
-SRSDLYSSGR-DRVGRQERG-------GYPPP-RDS-----------------------
YSSSSRGA-PRG--GGRGG------R-------SKRERTQ---S-EWFL-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADHPGKLF--------IGGLNRETNE
----KMLKAVFGKHGPISEV-LLI----KDR-TSKS-RGFAFITFENPADAKNAAKDMNG
KSLHGKAI-KVEQAKKPSFQSGGRRRPPAS-SRNRSPSG--SLRSA---RGSRGGTR---
----------------GWLPSQEGHLD-DGGYTPDLK---MS--------YSRGLIP---
----VKRGPS---SRSG-GPPPKKSAPS---------------------------AVAR-
S -NSWMGS-QGPMSQRR--ENYGV--------PPRRATISSWRNDRMS-----TRHDGYA
TNDGNHPSCQ-ETRDYAP---PSRGYAYRDNGHSNRDEHSSRGYRNHRSSRETRDYAPPS
RGHAYRDYGHSRRDESYSRGYRNRRSSRETREYAPPSRG--HGYRD---YGHSRRHESYS
RGYR-----------------------------------------NHPSSRETRDYAPP-
HR---DYAYRDYGHS--SWDEHS-SRGY------SYHDGYGEALGRDHS-EHLSGSSYRD
A--LQRYG----------------------------------------------------
------------------------------------------------------------
-TAHGAPPARGPRMSY----GG--STC-HAYSN-TRDR---------YGRSWESYS----
-SCGDFHYCDR-EHVCRKDQRNPPSLGRVLPDPR-EA-----------------------
CGSSSYVA-SIV---DGGES-------------RSEKGD----SSRY-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVVADCLGKFF--------IVGLNTETNE
----KALEAPF------VEV-LLM----KDREANKS-RGFAFVTFESPADAKDAARDMNG
KLLDGKAI-KVE------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MFEADHPGKLF--------FSGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDPETNKS-GGFAFVTFE------DAARDMNG
KSLDGKAI-KVEQVTKPSFESG-RRGPPPP-PRSRGPPR--GLRGG---RRGSGGTR---
-----------------GPPSR-----------MNFN---MS--------SSRGPLP---
----VKTGPP---PKNG-GPPPKRSALL---------------------------RPVSS
N--SGKGG-RAPV---------SR--------PLGREPLPSSRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTR------
----------DYGHSS-SRDDYL-SRGYS------HRDGYG--RDRDYS-DHPSGVSYRD
A--YESYS----------------------------------------------------
------------------------------------------------------------
-NSCSALPTRGPPPSY----GG--SSPYDDYSS-SRDG---------Y----DSHSS---
-SRSDLYSTGR-VRVGRQESGLHSSMERGYPPP-RDS-----------------------
YSSSSRGA-PRD--GGRGG------G------------GG---RSRH-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RRGPPPP-PRSRGPPR--GLRGGR-G--GSGGTR---
-----------------GPPSRGGHMD-DGGYSMNFN---MS--------SSRGPLP---
----VKRGPP---PRSG-GPPPKRSAPS---------------------------GPVR S
S--SGMGG-RAPVSRGR--DSYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYAPP-
PR---DYTYRDYGHSS-SRDDYP-SRGYS------DRDGY--GRDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGPPP----SYGG--SSRYDDYSS-SRDG---------YGGSRDSYSS---
-SRSDLYSSGR-DRVGRQDRGLPPSMERGYPPP-RD-----------------------S
YSSSSRGA-PRG--GGRGG------SRSDRG---------------GG--RSR------Y
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MMEADRPEKLF--------VGGLNLKTDE
----KALKAEFVKYGRINNV-FLM----KDRETNKS-RGFAFVTFESPADAKAAARDLNG
KYLDGKAI-KVVQAIKPAFKSSRWV---PP-PPGSSS----RSRFP---HGTRGCGS---
--------------SPQRPHSWGGPDD-GHGYAGYFD---QW--------PYRALMP---
----RKRGPP---PQRWAGPLRKRAAPS---------------------------SLAC-
SVGSEMRGGKALAVWGR--DGYSSVPLQRWASPPRKRAAPQSSLARIGGGGMPGKA----
------------------------------------------------------------
-----------------------------------------LATWEREGYS---------
---------------------------------------GSPLREPLPPCRDPGDFIPA-
LR---EYSRRYYSHSS-VRDYCP-LRGY------GKQNSYRG-RDRDYV-DHPS-GAYRE
P--LESYG----------------------------------------------------
------------------------------------------------------------
-GPCRATPGRGTPPSY----GG--GYRYGEYWG-RSPD----------------------
--------------------ALPVTLPDAYSRG---------------------------
----------------RDNS-------------S--NGR----SDRYGGGGHYEEYGGPS
PDTYSGGR--------------------------------------------SPIAYSRG
RDSSSNSYSRSHRYRG-DHYEEYQGHSPEATYSGGRSPEAA-------------------
----------NSGGRSPE------------------------------------------
------------------------------AANSGGRSPEASYSGGRHSSS--NSYGG--
------------------------------------------------------------
-----------------SRGHYEEYRGRSQDTHSRGRSPDTHSGGRYPS-----------
---AHTGGHSPDAHSRDRS------------------------------TNACSRDHD--
--------------------------------------SSSNSYGRSDHYGGGGSYEEYR
GHSHDAYSGGHSHDAYS-------------------------------------------
---GAHSPDTYSRGRD--SSSNSHGRSHRYGGGGR-Y-EYGGCSPDAYGGGRD-------
-------------------------------SYGRSDRYSRGRDRVGRRDRGLPLPMERS
SPTLHDSYSWSSCRVPRGGGRQGGRLERGEGWSRY

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RRGLPPP-PRSRGPPR--GLRGGR-G--GSGGTR---
-----------------GPPSRGGHMD-DGGYSMNFT---MS--------SSRGPLP---
----VKRGPP---PRSG-GPPPKRSAPS---------------------------GPVR S
S--SGLGG-RAPVSRGR--DGYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSREYPSSRDTRDYAPP-
PR---DYTYRDYGHSS-SRDDYP-SRGYS------DRDGY--GRDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGPPP----SYGG--SSRYDDYSS-SRDG---------YGGSRDSYSS---
-SRSDLYSSGR-DRVGRQDRGLPPSMERGYPPP-RD-----------------------S
YSSSSRGA-PRG--GGRGG------SRSDRG---------------GG--RSR------Y
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESGGRRGPPPP-PRSRGPPR--GLRGAR-G--GS-GAR---
-----------------GPPSRGSHLE-IIIASWLLL---LG--------SSRGPLP---
----MKRGPP---PRSG-GPPPKRSAPS---------------------------GPV RS
S---SMGG-RAPVSRGR--DGYGG--------PPRREPMPSRRDV-----YMSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------GYSSRDYPSSRDTRDYAPP-
PR---DYAYRDYGHSS-SRDEYP-SRGY-----S-DRDGYGGGRDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPARGPPP----SYGG--SSRYDDYGS-TRDG---------YG-SRESYSS---
-SRSDVYSSGR-DRVGRQDRGLPPSMERGYPPP-RD-----------------------S
YSSSSRGA-PRG--GGRGG------SRSDRG---------------GG--RSR------Y
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

--------------------------------------------------ISGLNLETNE
----KALETEFGKFGRIIEV-LLV----KD-ETSKS-RGFTFVTFESPADAKAV-ADMNS
ESLDGXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXX-----XXXXXXX---
-----------------XXXXXXXXXX-XXXXXXXXX---XX--------XXXXXXXXXX
X------X--------X-XXXXXXXXXX---------------------------XXX-X
-XXXXXX---XXXXXXX--XXXXX--------XXXXXXXXXXXXX-----XXXXXXXXXX
XXXX--------------------------------------------------------
-------------------------------------------------XX---------
------------------------------------------XXXXXXXXRDPRDFAPS-
PR---EFTYRDYGHFN-ARDDCP-SRGY------GDRDGNGGRD-RDYV-DHPSGGSYRD
P--FESYG----------------------------------------------------
------------------------------------------------------------
-DPRSATPARGPPPSY----GG--GGRYDEYRGCSPDA---------YGGGRDGYGGGGG
GGRSDRYSRGR-ERVGRGDRGLPPSMERGCPP-PRDS-----------------------
YSRSGRRV-PRG--GGRLGS-------------RVERGGG---RSRY-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RRGPPPP-PRSRGPPR--GLRGG---RGGSGGTR---
-----------------GPPSRGGHMD-DGGYSMNFN---MS--------SSRGPLP---
----VKRGPP---PRSG-GPPPKRSAPS---------------------------GPVR S
S--SGMGG-RAPVSRGR--DSYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYAPP-
PR---DYTYRDYGHSS-SRDDYP-SRGYS------DRDGYG--RDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-GRRHLRWK---HRY-MI------------TSS-SRDG---------YGGRRDSYSR---
-HV-----------------------VIGWQ-T-RQG-----------------------
LPPSMEGA-PRG--GGRGG------I-------KKTFGEK---KYSIAY-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADHPGKLF--------IGGLNRETNE
----KTLKAVFGKHGPISEV-LLI----KDR-TSKS-RGFAFITFENPADAKNAAKDMNG
KSLDGKAI-KVEQAKKPSFQSDGRRRPPAS-SRNRSPSE--SLRSA---RGSSGGTR---
----------------GWLPSHEGHLD-DGEYTPDLN---MS--------YSRGLTP---
----VKRGPS---SRSG-GPPPKKSAPS---------------------------AVAR-
S -SSWMGS-QGPMSQRR--ENYGV--------PPRRGTISSWRNDRMS-----PRYDGYA
TNDGNHPSCQ-ETRDYAP---PSRGYAYRDNVHSNRDEHSSRGYRNHRSSRETRDYAPPS
RGHAYRDCGHSRRHETYSRGYRNHRSSQETRDYPPPSRG--HAYHD---YGHSRRHESYS
RGYR-----------------------------------------NSPSSRETRDYTPP-
PR---DYAYRDYGHS--SWDEHS-SRGY------SYHDGYGEALGRDHS-EHLRGSSYRD
A--FQGYG----------------------------------------------------
------------------------------------------------------------
-TSHDAPPARGPRMSY----GG--STC-HAYSN-TRDR---------YGRSWESYS----
RSCGDFPYCDR-EHVCRKDQRNPPSLGRVLPDPR-EA-----------------------
YGSSSYVA-SIV---DGGES-------------RSEKGD----SSRY-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RRGPPPP-PRSRGPPR--GLRGGR-G--GSGGTR---
-----------------GPPSRGGHMD-DGGYSMHFN---MS--------SSRGPLP---
----VKRGPP---PRSG-GPPPKRSAPS---------------------------GPVR S
S--SGMGG-RAPVSRGR--DSYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYAPP-
PR---DYTYRDYGHSS-SRDDYP-SRGYS------DRDGY--GRDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGPPP----SYGG--SSRYDDYSS-SRDG---------YGGSRDSYSS---
-SRSDLYSSGR-DRVGRQERGLPPSMERGYPPP-RD-----------------------S
YSSSSRGA-PRG--GGRGG------SRSDRG---------------GG--RSR------Y
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------VMEVNQPGKLF--------IGGLSREANE
----KTLKAVFGKHGPLSEV-VWK----KDR-KNKC-RGFAFITFENPADAKNAAKDMNG
KFLYGKAI-KVEQANKPSFQSGGTRRIPPP-SRRRSPLG--SLRST---R-SSGGTR---
----------------GRHHSRGGHLG-DGGYTLDLH---TS--------SSMGKNG---
----VKRGPS---SRIG-SPPPKKSAPS---------------------------TVAR-
S -NDGMGG-QGPMSRGR--ESYAG--------PLRREPFSSWRNDSM-----SPRDDAYA
KKDFHHSKLQLHYQLSSP----FHFLPFRSRQDSSLPTSSQRLYISS-------------
--------------------LL-------QFIDIPVCGKHGITFWLRNALFESLIRSISS
PYFLGCKQFMFWIPEVDHL----------------KFVSLTHASRNHPSFRDTRCYAPP-
RK---DYAWCDYGRS--HRDEHS-SRGY------GEHDG----RGKDDS-EHPSRCSYRD
A--YQSYW----------------------------------------------------
------------------------------------------------------------
-TSRGAPPAPAPRMTF----GG--SSH-HDYNN-TRDR---------YDRSRESYS----
RSRGDFYSSGR-EHGGRKERTYPPSVDRVCRDPH-EE-----------------------
YGSSSHRA-SRK---GVGGR-------------RSGKGD---------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------VGGLSPETDE
----PALEAAFGPYGRIAEL-LLM----KDRETGKS-RGFAFVSFESPADAKAAARDLNG
KSLGGKAI-KVAQATKPAFDGARRGPPPAR-SRGRPGLR-----------GARGGPR---
-----------------RPPARAGPGA-DGGYAGDLD---PR--------PRA-PLAPKR
G------PPP---PRRA-GPPPKRPAPS---------------------------GPARS
GGGGGVRG------RGR--DGYAG--------PPRRSP--------------GPREEGCS
PRGG--------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------PS-
PR---AYAYRDD---G-ARDDGP-WRGY------GDRDGYAGRD-RAYA-DRAGGGPFRE
P--AESYG----------------------------------------------------
------------------------------------------------------------
-DPRSAG----PAPAY----GG---GRYGEARCCSPDA---------YAGGRAER-----
------SSGGR-DRLGRADRGPPPALERGCPPPPRDS-----------------------
YRRSGRRA-PRG------GG-------------RPERGGL---RSRY-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNLETDE
----KSLEATFGKYGRISEV-LLM----KDRETNKS-RGFAFITFESPADAKAAVRDMNG
KSLDGKAI-KVAQATKPAFESGRRGPPL---SRSRGRSR--GLRGA---RG--GGPR---
-----------------RPPSRGGPAD-DGGYAGDFD---LR--------PSRAPLP---
----MKRGPPP---PRRAGPPPKRAAPS---------------------------GPARS
G SGGGMRG-RAPAARGR--DGYEG--------PPRRDPPPPRRDP-----YLGSREGGYS
PRD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------GYSSRDYSSARDARDFAPS-
PR---EYTYRDYGHSS-ARDECP-SRGYG------DRDGYG-GRDRDYA-DHPSGGSYRD
P--FESYG----------------------------------------------------
------------------------------------------------------------
-DPRSAAPARGPPPSYG---GG--GGRYEEYRG-CSP--------DAYGGGRDGYAG---
-GRSERYSGGR-DRVGRADRGLPQSVERGCPPP-RES-----------------------
YSRSGRKV-PRG--GGRLGS-------------RSERGGG---GGRSRY-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFEGG-RRGPPPP-PRSRGPPR--GLRGGR-G--GSGGTR---
-----------------GPPSHGGHMD-DGGYSMNFN---MS--------SSRGPLP---
----VKRGPP---PRSG-GPPPKRSAPS---------------------------GPVR S
S--SGMGG-RAPVSRGR--DSYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYAPP-
PR---DYTYRDYGHSS-SRDDYP-SRGYS------DRDGY--GRDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGPPP----SYGG--SSRYDDYSS-SRDG---------YGGSRDSYSS---
-SRSDLYS----------------------------------------------------
YSSSSHGA-PRG--GGLGG------SRSDRG---------------GG--RSR------Y
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MMEADRPEKLF--------VGGLNLKTEE
----KALKAEFVKYGRIINV-FLM----KDRETNKS-RGFAFVTFESPADAKAAARDLNG
KYLDGKAI-KVARAIKPAFKSSWWG---PP-PPGSSS----CLRFP---HGTRGCGS---
--------------SPQRPHSWGGPDD-GHGYAGYFD---QW--------PYRAPMP---
----RKRGPP---PQRWASPLRKRAAPS---------------------------SLAR-
SVGSGMRG-KAPAVWGR--DGYSSVQLQRWAGPTRKRAVPPSSLARIGGGGMPGKA----
------------------------------------------------------------
-----------------------------------------PAMWGREGYS---------
---------------------------------------GPLLREPLPRCRDPGDFIPA-
LR---EYSRRYYSHSS-VRDYCP-LRGY------GKQNSYRG-RDRDYV-DHPSRGSYRE
P--LESYG----------------------------------------------------
------------------------------------------------------------
-GPCGATPGRGTLPSY----GG--GYRYEGYRG-RSPD----------------------
--------------------ALPVTLPDAYSGG---------------------------
----------------RDSS-------------S--NGR----SDHYGGRGHYEEYGGPS
PDTYSGG-----------------------------------------------------
RDSSSNSYSWSHRYRGGGHYEEYQGRSPEATYSGGRSPEAA-------------------
----------NSG-----------------------------------------------
-----------------------------------GRSPEAAYSGGRSPEA--ANSG---
------------------------------------------------------------
-----------------------------------GRSP---------------------
------------------------------------------------------------
-------------------EAAYSGGRSPEAAYSGGRHSSSNTY-------GGDHYEEYR
GCSQDTHSGGRSPDTHSGGRYPRAHTGGH-SPNAHSGDRSTDACSRGHDSSSNSYGGGSY
EEYQGHSPDTYSRG----------------------------RSPDAYGGGHDSSINSHG
LSDRYAGAGRYKEYLGSSPDAYGGGRNSSSNSYGRSDSYSRGRDRVGRPDLGLPLPMERS
SPPLHDSYSRSSCRVPRGGGRQGGRLERGEGWSRY

-------------------------------MMEADRPEKLF--------VGGLNLKTEE
----KALKAEFVKYGRIINV-FLM----KDRETNKS-RGFAFVTFESPADAKAAARDLNG
KYLDGKAI-KVARAIKPAFKSSRWG---PP-PPGSSS----CLRFP---HGTRGCGS---
--------------SPQRPHSWGRPDD-GHGYAGYFD---QW--------PYRAPMP---
----RKRGPP---PQRWASPLHKRAAPS---------------------------SLAR-
SVGSGMRG-KAPAVWGR--DGYSSVQLQRWAGPPRKRAVPLLSLARTGGGGMPGKA----
------------------------------------------------------------
-----------------------------------------PAMWGREGYS---------
---------------------------------------GPLLREPLPRCRDPGDFIPA-
LR---EYSRRYYSHSS-VRDYCP-LRGY------GKQNSYRG-RDRDYV-DHPSRGSYRE
P--LESYG----------------------------------------------------
------------------------------------------------------------
-GPCGATPGRGTLPSY----GG--GYRYEGYRG-RSPD----------------------
--------------------ALPVTLPDAYSGG---------------------------
----------------RDSS-------------S--NGR----SDRYGGRGHYEEYGGPS
PDTYSGG-----------------------------------------------------
RDSSSNSYSWIHRYRGGGHYEEYQGRSPEATYSGGRSPEAA-------------------
----------YSG-----------------------------------------------
-----------------------------------GRSPEAAYSGGRHSSS--NTYGG--
------------------------------------------------------------
-------------------DHYEEYRGCSQDTHSGGRSPDTHSGGRYPR-----------
---AHTGGHSPNAYSGDRS------------------------------TDACSRGHAAG
AA---------RPRPPTAGAARPSGGRSPEAAYSGGRHSSSNTYGGSQRYGGGDHYEEYR
GCSQDTHSGGRSPDTHSGGRYPRAHTGGH-SSSNSYGR------------SDHYGGGGSY
EEYRGHSPDTYSRGRD--SSSNSHGRSHRYGGGGR-YEEYGGRSPDAYGGGHDSSINSYG
LSDRYAGGGRYKEYLGSSPDAYGGGRNSSSNSYGRSDSYSRGRDRVGRPDLGLPLPMERS
SPPLHDSYSWSSCRVPRGGGRQGGRLERGEGWSRY

------------------------------------------------------------
------------------------------------------------------------
-SLDGKAI-KVEQATKPSFESG-RRGPPPP-PRSRGPPR--GLRGGR-G--GSGGTR---
-----------------GPPSRGGHMD-D-GYSMNFN---MS--------SSRGPLP---
----VKRGPP---PRSG-GPPPKRSAPS---------------------------GPVRS
S--SGMGG-RAPVSRGR--DSYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYAPP-
PR---DYTYRDYGHSS-SRDDYP-SRGYS------DRDGY--GRDRDYS-DHPS-GSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGPPP----SYGG--SSRYDDYSS-SRDG---------YGGSRDSYSS---
-SRSDLYSSGR-DRVGRQDRGLPPSMERGYPPP-RD-----------------------S
YSSSSRGA-PRG--GGRGG------SRSDRG---------------GG--RSR------Y
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RRGPPPP-PRSRGPPR--GLRGGR-G--GSGGTR---
-----------------GPPSRGGHMD-DGGYSMNFN---MS--------SSRGPLP---
----VKRGPP---PRSG-GPPPKRSAPS---------------------------GPVR S
S--SGMGG-RAPVSRGR--DSYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYAPP-
PR---DYTYRDYGHSS-SRDDYP-SRGYS------DRDGY--GRDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGPPP----SYGG--SSRYDDYSS-SRDG---------YGGSRDSYSS---
-SRSDLYSSGR-DRVGRQDRGLPPSMERGYPPP-RD-----------------------S
YSSSSGGA-PRG--GGRGG------SRSDRG---------------GG--RSR------Y
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESGGRRGPPPP-PRSRGPPR--GLRGGR-G--GS-GAR---
-----------------GPPSRGSHL---------------G--------SSRGPLP---
----MKRGPP---PRSG-GPPPKRSAPS---------------------------GPVR S
S--SGMGG-RAPVSRGR--DSYGG--------PPRREPMPSRRDV-----YMSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYAPP-
PR---DYAYRDYGHSS-SRDEYP-SRGYSFSSYS-DRDGYGGGRDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPARGPPP----SYGG--SSRYDDYGS-TRDG---------YG-SRESYSS---
-SRSDVYSSGR-DRVGRQDRGLPPSMERGYPPP-RD-----------------------S
YSSSSRGA-PRG--GGRGG------SRSDRG---------------GG--RSR------Y
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

---------------------------------EADRPGKLF--------IGGLNIETNE
----KTLEEVFGKYGRIVEV-LLM----KDGETNKS-RGFAFITFESPADAKDAAKDMNG
KVK---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RRGPPPP-PRSRGPPR--GLRGGR-G--GSGGTR---
-----------------GPPSWGGHMD-DGGYTMNFN---MS--------SSRGPLP---
----VKRGPP---PRSG-GPPPKRSAPS---------------------------GPVR S
S--SGMGG-RAPVSRGR--DSYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPT-----DYAPP-
PYENYSIFYRDYGHSS-SRDDYH-QE------------AI--CRDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGPLP----SYGG--SSRYDDYSS-SRDG---------YGGSRDSYSS---
-SRSDLYSSGR-DRVGRQERGLRPSMERGYPPP-RN-----------------------S
YSSSSREA-PRG--GGRGG------SRSDRGEAEADTRNK---QN---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------ICGLNTET--
--------IVFGKHGRLVEV-L----------------GFAFVTFESPGDDKDAARDMYG
RSLDGKAI-KMEPTTKPSFESG-RRGPPPP-PRSRGPPR--GLRGE---RGGSGGTR---
-----------------RPPSWGGHMD-DGGYSMNFN---MS--------SSRPP-----
-------------LRSG-GPRPKRSALS---------------------------GPVHS
S--SGMGG-RAPVSHRR--DSYGG--------PPGKELLPSHRDI-----YF--------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------YSSRDYPSSRDTRDYTPP-
SG---DYTYRDYGHSS-SRDDYP-SRGYG------NREGYG--RDRDYS-DHPSGGSYRD
S--YDSYG----------------------------------------------------
------------------------------------------------------------
-NSCSAPPTRGPLPAY----GG--SSRYDDYSS-SRDG---------YGGSQTV------
------TQHGR-DRVGRQERGLPPSVERGYPPP-RDS-----------------------
YSSSRRGR-SRY------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADR-GKLF--------IGGXXXXXXX
----XXXXXXXXXXXXXXXX-XXX----XD-RELKS-RVVAFITFESA-DDKAAARDMNG
KFDK---TIKMAQATKPA-ESGRRGPPPLR-SRGRRRLRGV---------RGGGGPR---
-----------------RLPSRGGPLD-DGAYGEHFD---PR--------ASRAPMPMKR
GPSTRR----------T-GPPPKRVAPPSS-------------------------GPARS
-GSGGMRG-RAPAPRGR--DGYVG--------PLRREPPLSRRDP-----YLGPREEGYS
PPDS--------------------------------------------------------
-------------------------------------------------YS---------
-------------------------------------------SRDYPS-RDPRDFAPS-
PR---EYSYRDYGHSS-ARDDCP-SRGY------SDRDDYGGRS-RDYL-DHPSAGSYRD
V--FESYG----------------------------------------------------
------------------------------------------------------------
-DPRGAAPGRDPPPSY----GHGGGGRYVGYSGCSPDA---------YGSGRDSYT----
SGRSDRYSRGR-ERVGRPDRGLHPSMERGCPP-PRDS-----------------------
YSRSGRRV-PRG--GGRLGS-------------RAERGGG---RSRY-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RRGLPPP-PRSRGPPR--GLRGGR-G--GSGGTR---
-----------------GPPSRGGHMD-DGGYSMNFT---MS--------SSRGPLP---
----VKRGPP---PRSG-GPPPKRSAPS---------------------------GPVR S
S--SGLGG-RAPVSRGR--DGYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSREYPSSRDTRDYAPP-
PR---DYTYRDYGHSS-SRDDYP-SRGYS------DRDGY--GRDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGPPP----SYGG--SSRYDDYSS-SRDG---------YGGSRDSYSS---
-SRSDLYSSGR-DRVGRQERGLPPSMERGYPPP-RD-----------------------S
YSSSSRGA-PRG--GGRGG------SRSDRG---------------GG--RSR------Y
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-K VEQATKPSFETG-RRGPPPP-PRSRGPPR--GLRGGR-G--GSGGTR---
-----------------GPPSRGGHMD-DGGYSMNFN---MS--------SSRGPLP---
----VKRGPP---PRSG-GPPPKRSAPS---------------------------GPVR S
S--SGMGG-RAPVSRGR--DSYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYAPP-
PR---DYTYRDYGHSS-SRDDYP-SRGYS------DRDGY--GRDRDYS-DHPSGGSYRD
S--YDSYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGPPP----SYGG--SSRYDDYSS-SRDG---------YGGSRDSYSS---
-SRSDLYSSGR-DRVGRQERGLPPSMERGYPPP-RD-----------------------S
YSSSSRGA-PRG--GGRGG------SRSDRG---------------GG--RSR------Y
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADCPGKFF--------IGGLNMETNE
----KALEAPF------VEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
NG--------------------RR--GLPPPPRSRGPPR--SLRGG---RGGSGVTR---
-----------------EPPSWGGHMD-DGGYSMHFN---MS--------SSREPLL---
----VKRGPP---PRSG-GLSPKRSAPP----------------------------KR--
SAPVHSSR-RAPLSRGR--D-----------------------NV-----YLSPRDDVSS
SR----------------------------------------------------------
------------------------------------------------------------
---------------------------------------------DYPSSCNTRDYAPP-
PR---DHTYR-----------------Y------SDRDGYDRD--HDYS-DHPSGSSYRD
S--YESYD----------------------------------------------------
------------------------------------------------------------
-NSHSAPPTQGPPPFY----AG--SSCYHDYSS-SHSY-----------------S----
SSRSDLHSSGC-DRLGRQERGLAPFIERGYPS-PCDS-----------------------
YSSSSCRA-PRG--GGRGGS-------------RSDRGGG---KSRY-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

--------------------------------VEADRPGKVF--------VGGLSTETNK
----KALEAVFGKYGRIVEA-LLR----KDHETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RHG----------------------------------
-----------------------LHMD-DGGYSMNFN---MS--------SSRGPLP---
----VKRGSP---LRSG-SPPPKTSAPS---------------------------GPVR S
S--SGMGG-RAPVSRGR--DSYGD--------PPRREQLPSGRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYPSRDYPSSCDTRDYAPP-
PR---DYTYCDYGHFS-SHGDYP-SRGYS------DRDGYS--RDC----------SYRD
S--HESYG----------------------------------------------------
------------------------------------------------------------
-NSGSAPPTRGPPCGY------------DDYSS-SPDR---------Y----DSYSS---
-SQSDLYSSGG-DQVCRQERGCG--ALRGGGHG-GS--QSDRGGGRSRYYKQTKLWTKIP
VQRNKQKV--QT-------ILS--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RRGPPPP-PRSRGPPR--GLRGGR-G--GSGGTR---
-----------------GPPSRGGHMD-DGGYSMNFN---MS--------SSRGPLP---
----VKRGPP---PRSG-GPPPKRSAPS---------------------------GPVR S
S--SGMGG-RAPVSRGR--DSYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYAPP-
PR---DYTYRDYGHSS-SRDDYP-SRGYS------DRDGY--GRDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGPPP----SYGG--SSRYDDYSS-SRDG---------YGGSRDSYSS---
-SRSDLYSSGR-DRVGRQERGLPPSMEXXXXXX-XX-----------------------X
XXXXXXXX-XXX--XXXXX------XXXXXXXXXXXX--------X--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNLETDE
----KALEAEFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKAAARDMNG
KSLDAHLP-SCLITPFICVDQ---------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RRGPPPP-PRSRGPPR--GLRGGR-G--GSGGNR---
-----------------GPPSRGGHMD-DGGYSMNFN---MS--------SSRGPLP---
----VKRGPP---PRSG-GPPPKRSAPS---------------------------GPVR S
S--SGMGG-RAPVLRGR--DSYGG--------PPRREPLPSRRDV-----YLSPTDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYAPP-
PR---DYTYRDYGHSS-SRDDYP-SRGYS------DRDGY--GRDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSLLEGGWGMLLI--RFQG--VFQLKPP-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KVGMEICF-AVAANQKYCSMELWN------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEI-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RRGPPPP-PRSRGPPR--GLRG------GSGGTR---
-----------------GPPSRGGYMD-DGGYSMNFN---MS--------SSRGPLP---
----VKRGPP---PRSG-GPPPKRSTPS---------------------------GPVR S
S--SGMGG-RAPVSRGR--DSYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYAPP-
PR---DYTYRDYSHSS-SRDDYP-SRGYG------DRDGY--GRDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGPPP----SYGG--SSRYDDYSS-SRDG---------YGGSRDSYSS---
-SRSDLYSSGR-DRVGRQERGLPPSMERGYPPP-RD-----------------------S
YSSSSRGA-PRG--GGRGG------SRSDRG---------------GG--RSR------Y
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MIEADRPGKLF--------IGGLNTETNG
----KALEAVFGKHGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKLLYHVEEIVTEVHLEGSHCPLVEM-FICPQEMMGILLKTA---IQAEITQVLVI
LEIMHHHHEIILTVIM-VIPVHVMTIH-QEAIAIEMD---MVVIVTIQIIQVEVPTEIHM
RVMVT-HVVL---HLHE-GPRHLMVEAVAMMITAAHVTDMLEVETVTQAAEVISTQVVVI
GLADKKEG-FPLLWKGG--TLLHV--------IPTAVQAAE-HQE-----VVAVEEADLI
E-----------------------------------------------------------
------------------------------------------------------------
-------------------------------------------GEAEADTRNKQNFGPK-
S----------------QFKETK-SGNY------SV---------------ITTQGLLKG
KIVLHCLN----------------------------------------------------
------------------------------------------------------------
-SLLS------SPP----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

--------------------------------VEADRPGKLF--------IGGLNMETNE
----KALEAVFGK-GRIVEV-LLM----KDHETNKS-RGFAFVTFESPADAKDAAR----
KSLDG KAI-KVEQATKPSFESG-RRGPPPP-PRSRGPPR--GLRGG---RGGSRGTR---
-----------------GPPSRGGHMD-DGGYSMNFN---MS--------SSRGPLP---
----VKRGPP---PRSG-GPPPKRSAPS---------------------------GPVR S
S--SRMGG-RPPVSRGR--DSYRG--------PPQREPLPSPGDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSIGDYPSSRDTRDYASP-
PR---DYTYHDYGHPS-S--------------------------------HHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NS-SAPPTRGPLPSY----GG--SSRYDYYSS-SRDG---------YGGSRDS------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEI-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RRGPPPP-PRSRGPPR--GLRG------GSGGTR---
-----------------GPPSRGGYMD-DGGYSMNFN---MS--------SSRGPLP---
----VKRGPP---PRSG-GPPPKRSTPS---------------------------GPVR S
S--SGMGG-RTPVSRGR--DSYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------NYSSRDYPSSRDTRDYAPP-
PR---DYTYRDYSHSS-SRDDYP-SRGYG------DRDGY--GRDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSASPTRGPPP----SYGG--SSRYDDYSS-SRDG---------YGGSRDSYSS---
-SRSDLYSSGR-DRVGRQERGLPPSMERGYPPP-RD-----------------------S
YSSSSRGA-PRG--GGRGG------SRSDRG---------------GG--RSR------Y
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------QAGAPPPKRSAPS---------------------------GPVRS
S--SGMGG-RDPISRGR--DNYGG--------PSRREPMPSRREV-----YMSPRDDGYN
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYQSSRDNRDYAPP-
PR---DFAYCDYGHSG-SRDDYQ-SRGYS------D-------RDRDYS-DHPSGGSYRD
P--YESYG----------------------------------------------------
------------------------------------------------------------
-NSHSAPPARGPPPSY----GG--SSRYDDYS---RDG---------YGGSRESYSS---
-SRSDIYSSGRGDRVGRQDRGLPPSMDRGYPPP-CDS-----------------------
YSGSRRGA-PRG---GRGGS-------------RSDRRGG---RSRY-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNLETDE
----KGLEAAFGKYGRIIEV-LLM----KDRETSKS-RGFAFVTFENPADAKAAARDMNG
KSLDGKAI-KVAQATKPVFESGRRGPPP---PRSRGRPR--GLRGT---RG--GGPR---
-----------------RPPSRGGSVD-EGGYTGDFD---LR--------PSRAPMP---
----LKRGPP----PRRAGPPPKRAAPS---------------------------GPARS
--GAGIRG-RAAGSRGR--DGYGG--------PPRRELPPPRRDP-----YLGPRDEGYS
PRE---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSTRDPRDFAPS-
PR---DYTYRDYGHSS-ARDECP-SRGYC------ERDGYG-GRERDY--EHPSGGSYRD
P--FDSYG----------------------------------------------------
------------------------------------------------------------
-DPRGAGPARGPPPSYG---G----GRYDEYRG-CSP--------DGYSG-RDSY-----
--RSERYSSGR-ERVGRPERGLPPSVERNCPAP-RDS-----------------------
YSRSGRRAPPRG--GGRVGS-------------RLERGGG---RSRY-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MIISIDPDKLYDKIQHPFMIKTLNKLVID
GMYFKILRAIYDK--PTSNI-ILN-----IR-------TW-KLSLRKP--------AHDK
DYLDRKAI-KIEQAKKPSYQSQGRQRPPPS-SRNRSPSG--SLRSA---RGSSE------
-----------------------EQEE-DGGYTPDLK---MS--------YSRGLTP---
----VKRGPS---SRSG-GPPLKKSAPS---------------------------AVAR-
S-SSWMGS-QGKCYLTERPENYGV--------PPRRGTISSWRNDRM-----SPRYDGYA
TNDGNHPSCQ-ETRDYAP---PSRGYAYRDNGHSNRDEHSSRGYRNHRSSRETRDYAPPS
RGHAYRDCGHSRRHETYSRGYRNHRSSRETRDYPPPSRG--HAYHD---YGHSRRHESY-
----------------------------------------SRGYRNHPSSRETRDYAPP-
SR---D-----YGHS--RQDEHS-SRGY------RYY----------HS-EHLSGSSYRD
A--FQGYG----------------------------------------------------
------------------------------------------------------------
-TSHDAPPARGPRMSY----GG--STC-HAYSN-TRDR---------YGRSWESYS----
RSCGDFHYCDH-EHVCRKDQRNPPSLGRVLPDPR-EA-----------------------
YGSSLYVA-SIV---DGGES-------------RSEKGD----SSRY-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFITFESPADAKDAARDMNG
KSLDGKAI-K VEQATKPSFETG-RHGPPPP-PRSRGPPR--GLRGGR-G--GSGGTR---
-----------------GPPSRGGHMD-DGGYSMNFN---MS--------SSRGPLP---
----VKRGSP---PRSG-GPPPKRSAPS---------------------------GPVR S
S--SGMGG-RAPVSRGR--ARYGG--------PPRREPLPSHRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYASP-
PR---DYTYHDYGYSS-SHDDYP-SRGYS------DRDGY--GRDRDYS-DHPSGGSYRD
S--YDSYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGPPP----SYGG--SSRYDDYSS-SRDG---------YGGSRDSYSS---
-SRSDLYSSGC-DRVGRQERGFPPSMERGYPPP-RD-----------------------S
YSSLIRGA-PKG--GGRGG------SRSDRE---------------GG--RSR------Y
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVVADCPGKFF--------IVGLNMETNE
----KGLEAPFVEVLLMK-----------DREINKS-RGFAFVTFESPADAKDAARDMN G
--------------------NG-RYGPPTL-PRSRGPPR--GLRGG---RGGSGGTR---
-----------------GPPSWGRHMD-DGGYSMHFN---TR---------TREPLP---
----VKRGPS---PRSG-GPSSKTSAPS---------------------------GPVH S
S--SGMEG-RAPLSHGR--DSYGG--------PPRRELPPSRRDV-----YLSPRDDAYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SSSSRDYPSSRDTRDYAPP-
PR---DYTYHDYGHSR-SCDGHP-SRGYS------DRDGYD--RDHDYS-DHPSGSSYRD
S--YESYD----------------------------------------------------
------------------------------------------------------------
-NSHSAPPKQGPPPFY----AG--SSLYHDYSS-SRDG---------YGRSEDSYSS---
-SRSDLHSSG-----Q---TGLLASLERGYPSP-RDS-----------------------
YSSSSCRA-PRG--GGCGG------R------------GG---RSRY-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKLT--VNI-----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNMETNE
----KALEAVFGKYGRIVEV-LLM----KDCETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RRGPPPP-PRSRGPPR--GLRGGR-G--GSGGTR---
-----------------GPPSQGGHVD-DGGYSMNFN---MS--------SSREPLP---
----VKRGPP---PRSG-DPPPKRSAPS---------------------------GPVR S
S--SGMGG-RAPVSRGR--DSYGG--------PPRREPLPSCRDV-----YF--------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------YSSRDYPSSRDTRDYAPP-
PR---DYTYRDCGHSS-SRDHYP-SSGYS------DRDGY--GRDHDYS-DHPSGGSYRD
S-----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALETVFGKYGRIVEV-LLI----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFERG-RHGPPPP-PRSRGPPR--GFRAGR-G--GSGGTR---
-----------------GPPSRGGHMD-DGGYSMHFN---MS--------SSRGPLP---
----VKRGPP---PRSG-GPSPKRSAPS---------------------------GLVR S
S--SGMGG-RAPLSRGR--DSYGG--------PPRREPLPSRRDV-----YLYPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYAPP-
PR---DYTYRDYGHSS-SRDDYP-SRGYG------DRDGY--GRDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGPPP----SYGG--SSRYDDYSS-SRDG---------YGGSRDNYSS---
-SRSDLYSSGC-DRVGRQERGLPPSVERGYPSP-RD-----------------------S
YSSSSRGA-PRG--GGPGG------SRSDRG---------------GG--RSR------Y
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADLSGKLF--------ID--------
---------------------------------GKS-GGFAFVTFESPADAKDAARDMNG
KSLDGKNI-KVEQATKPSFESSRCG--S------RGPPR--V-----------EELW---
-----------------DL---LTWRD-DSGYSMNFN---MS--------SSRGPRP---
----VKRGQP---VQSG-GSASYK--------------------------------MV--
G SSSGMGG-RAPASRGR--DSYGG--------PPRREPLPSCRDV-----YLSSRDNGYS
TKDS--------------------------------------------------------
-------------------------------------------------YS---------
------------------------------------------SRDSSS--HDIRDYAP--
PR---DYTYRDYGHHFSSRDDYP-SRGY------SDSDGYGWD--RDYA-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGPPPSY----GG--SRHCDDYSS-SRDG---------YD----SYS----
SSRSDLYSSGR-NRAVRQERGLPLSMERRYPP-PHDS-----------------------
YSSSCHGA-PRG--GGCGAS-------------GSDRGGG---RSRYQE------QTKLW
---------------TKIPIQRN-KPKVETILS---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

--------------------------------VEADRPGKVF--------VGGLSTETNK
----KALEAVF------VEA-LLR----KDHETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RCGLPPP-PRSRGPPR--GLRGG---RGGT-------
------------------EPSWGRHMD-DGGYSMNFN---MS--------SSRGPLP---
----VKRGSP---LRSG-SPPPKTSAPS---------------------------GPVR S
S--SGMGG-RAPVSRGR--DSYGD--------PPRREQLPSGRDV-----YLSPRDDGYT
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYPSRDYPSSRDTRDYAPP-
PR---DYTYCDYGHFS-SHGDYP-SRGYS------DRDGYS--RDC----------SYRD
S--HESYG----------------------------------------------------
------------------------------------------------------------
-NSGPPPSYGEAVATM------------I-------------------TALRQLFKQ---
-KRASPF--CG-NPQRDSYRNSSRGALRGGGHG-GN--QSDRGGGRSRY-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RRGPPPP-PRSRGPPR--GLRGGR-G--GSGGTR---
-----------------GPPSRGGHMD-DGGYSMNFN---MS--------SSRGPLP---
----VKRGPP---PRSG-GPPPKRSAPS---------------------------GPVR S
S--SGMGG-RAPVSRGR--DSYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYAPP-
PR---DYTYRDYGHSS-SRDDYP-SRGYS------DRDGY--GRDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGPPP----SYGG--SSRYDDYSS-SRDG---------YGGSRDSYSS---
-SRSDLYSSGR-DRVGRQERGLPPSMERGYPPP-RD-----------------------S
YSSSSRGA-PRG--GGRGG------SRSDRG---------------GG--RSR------Y
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RRGPPPP-PRSRGPPR--GLRGGR-G--GSGGTR---
-----------------GPPS RGGHM----------------------------------
------------------------------------------------------------
----------APVSRGR--DSYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYAPP-
PR---GYTYRDYGHSS-SRDDYP-SRGYS------DRDGY--GRDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-KILVKGLE---------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KVLEA--------------M----KDRETNKS-RGFAFVTFESPADAKDACSWPIF
-PPLDIP-----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RRGPPPP-PRSRGPPR--GLRGGR-G--GSGGTR---
-----------------GPPSRGGHMD-DGGYSMNFN---MS--------SSRGPLP---
----VKRGPP---PRSG-VLLPRDLHLQ---------------------------DQF--
---SGRG------GSHL--DSYGG--------QHRREPLPSRRDV-----YLYPRDDGDS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYAPP-
PR---DYTYRDYGHSS-SRDDYP-SRGYS------DRDGY--GRDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGPPP----SYGG--SSRYDDYSS-SRDG---------YGGSRDSYSS---
-SRSDLYSSGR-DRVGRQERGLPPSMERGYPPP-RD-----------------------S
YSSSSRGA-PRG--GGRGG------SRSDRG---------------GG--RSR------Y
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-K VEQATKPSFESGGRRGPPPP-PRSRGPPR--GLRGGR-G--GS-GAR---
-----------------GPPSRGSHL---------------G--------SSRGPLP---
----MKRGPP---PRSG-GPPPKRSAPS---------------------------GPV RS
S---SMGG-RAPVSRGR--DSYGG--------PPRREPMPSRRDV-----YMSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------GYSSRDYPSSRDTRDYAPP-
PR---DYAYRDYGHSS-SRDEYP-SRGYSLSSYS-DRDGYGGGRDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPARGPPP----SYGG--SSRYDDYGS-TRDG---------YG-SRESYSS---
-SRSDVYSSGR-DRVGRQDRGLPPSMERGYPPP-RD-----------------------S
YSSSSRGA-PRG--GGRGG------SRSDRG---------------GG--RSR------Y
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRLGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDWETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKKS-TIDVF----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADHPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDCETNKS-RGFAFVTFENPADAKDAARDMNE
KSLDGKAI-KVEQATKPSFESG-----------------------------GRGGTR---
-----------------GPPSWGGHMD-DGGYSMNFN---TS--------SSRGPLP---
----VKRGPP---PRSG-GPPPKRSAPS---------------------------GPVR S
S--SGMGG-RALVSRGR--DSYGG--------PPRRELLPSRRDV-----YLSPRDDGFS
RKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYCSRDYPSSRDPRDYAPP-
PR---DYTSRDYGHSS-SHDDYP-PRGYS------DRVGY--GRDHDYS-DHPGGGSYRD
S--CESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGPP----------------------------------------SYSS---
-SRSDLYSSGR-DRVGRQERGLPPSMERGYPPP-RD-----------------------S
YSSSSRGA-PRS--GGRGG------SRSDRG---------------GG--RSR------Y
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RRGPPPP-PRSRGPPR--GLRGGR-G--GSGGTR---
-----------------GPPSHGGHMD-DGGYSMNFN---MS--------SSRGPLP---
----VKRGPP---PRSG-GPPPKRSAPS---------------------------GPVR S
S--SGMGG-RAPISRGR--DSYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYAPP-
PR---DYTYRDYGHSS-SRDDYP-SRGYS------DRDGY--GRDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRNAPPTRGPPP----SYGG--SSRYDDYSS-SRDG---------YGGSRDSYSS---
-SRSDLYSSGR-DRVGRQERGLPPSMERGYPPP-RD-----------------------S
YSSSSRGA-PRG--GGRGG------SRSDRG---------------GG--RSR------Y
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

------------------------------------------------------------
-------MVEADRPGKLFIV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RRGPPPP-PRSRGPPR--GT-------------R---
-----------------GPPSHDGHMD-DGSYSMNFN---MS--------SSRGPLP---
----VKRGPP---PRSG-GPPPKRSAPS---------------------------GPVR S
S--SGMGG-RAPVSRGR--DSYGG--------PPRRETLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSS----HYAPP-
LR---DYTYCEYGHSS-LYGDSR-D-GYG------RDRDYS---------DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGPPPSY----GG--SSRYDDYSS-SRDR---------YGGSRDSYSS---
-SRSDLYSSGR-DRVGRQERALPPSMERGYPPP-HDS-----------------------
YSSSSRGA-PRG--GGRGG------S-------RSDRGGG---RSRY-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

------------------------------MVEGADCPGKLL--------IDGLNTETNE
----KALEAIFGKYGRIVEV-LLM----KDHETNKS-RVFASVTFESPADTKDAPRDMNG
KSLDGKAI-KVEQASKPSFESG-RRGPPPS-PRSRGLPR--GLRGG---RGGSGGTR---
-----------------GRPSREGHMD-DDRYSMNFK---MS--------SSRGPLP---
----VKRGPP---PRSG-EGGSSSEE----------------------------------
------------IYLFR-----TT--------LQQPEPLPSHREV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYPSRDYPSSHDTRDYAPP-
PR---DYTYRDYIEAV-VIEMDM------------------------VV-IMTIHIIQRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSHSAPPTRGLPQSY---------------------------------GGSNSYSS---
-SRSDLHSSGH-EQVGRQERGLPPSMKRGYPPP-CDS-----------------------
YSSSSRGA-PRG--GSPGG------S-------RSDRGGG---RSRY-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MMEVNQPGKLF--------IGGLSREANE
----KTLKAVFGKHGPLSEV-VWK----KDR-KNKC-RGFAFITFENPADAKNAAKDMNG
KFLYGKAI-KVEQANKPSFQSGGTRRISPP-SRHRSPLG--SLKSI---RNSSGGTR---
----------------GRHHSRGRHLG-DGGYTLDLH---MS--------SSRGTFG---
----VKRGPS---SRIG-SPPPKKSAPS---------------------------TVAR-
S -NGGMGG-QGRMSRGR--ESYAG--------PLRREPF-SWRNDST-----SPRDDAYA
TKDSTSLLTQAF----NP----LFC-----------------------------------
-------------------------------LG----------------CF----HCSIS
S----CKWVMFWILEVDHL----------------KFVSLTYASRNHPSFRDTRCYSPP-
RK---DYAWCDYGRS--RRDEHS-SRGY------GEHDG----RDRDDS-GHPSRCSYRD
A--YQR------------------------------------------------------
------------------------------------------------------------
-TSRGAAPAPAPRMTF----GG--SSR-HDYNN-TRDR---------YDRSRESYS----
RSRGDFYSSGR-EHSGRKERTYPPSVDRVRRDPH-EE-----------------------
CGSSSYRA-SRK---GVGGR-------------RSEKGD---------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADGPGKLF--------MGGLNTKTNE
----KALEAVFGKYGGIVEV-LLM----KDRATNKS-RGFAFVTFGSPADAKNVARDMNG
KSLEGKAI-KVEQATKSSFESG-RRGPPPP-PRSKGPPR--GLRGG---KGGSGGTR---
-----------------GPPSRRGHMD-DSRYSMNFN---MS--------SSRGPLP---
----GKRGPP---PRSG-------------------------------------------
----------------R--DSHGS--------PPQREPLPSRRDV-----YLPPRDDGYS
TKG---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SSSSRDNPSSRDTRDCY---
------------------------------------GNRDG--DGRDYS-DHPSRGSYGD
S--CESYG----------------------------------------------------
------------------------------------------------------------
-TSPSA------PPSY----RG--SSRYDDDGS-SRDR---------YGGSRDSYSS---
-SRSDLYSSGR-DRVDRQERRLPASMERGYPAP-HDS-----------------------
YSSSSHGA-PRG--GGREG------S-------RSDRGGG---RSRY-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEVDCPGKLY--------IGGLNRETNE
----KMLKAVFVKHGPISEV-LLI----KDR-TSKS-RGFAFITFENPADAKNAAKDMNG
KSLDGKAI-KVEQAKKPSFQSGGRRRPPPS-SRNRSPSG--SLRSA---KGSSRGIR---
----------------GWLPSHEGHLD-DGGYTLDLN---MS--------SSRGAIP---
----VKRGPS---SRSG-GPLPKISALS---------------------------AMAR-
S -NSWIGS-QGPMSRGR--ENYGS--------PPCREPTSSWRNDHM-----SRRDDGYA
TKERTHQSSRD-TRDYA-------------------------------------------
----------------------------------PLSRV--YTYRD---YG---------
--------------------------------RSSPDEHSSRGYRNHPSSRETRDYALP-
PK---DYTYPAYGRS--SRDEHS-SRGY------SDPDGYSAARGRDHS-EGPSGSSYRD
A--FQGYG----------------------------------------------------
------------------------------------------------------------
-TSHGAPPARGPRMSY----GG--STC-RDY-N-TRDG---------YGRRWESYS----
RSCGDSYSCGR-EHAGRKDQRNLPSLDRLLPAPR-EA-----------------------
YGSSSYVS-STV---DGDKS-------------RS-KGD----LSRC-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

---------------------------------EADRPRKLF--------IGGLNIETNE
----KVLEAVC------VEI-LLM----KHHETNKS-RGFS-------------------
--LDGKSI-KVEQATKPSFERWSCWHGPPLPQRSGDPPR--DLRGG------SGGTM---
-----------------GPPSRGGYMD-NGSYSMNFN---MR--------PP--------
-------------PQSC-SPPPVRSMPS---------------------------DPV--
RSSSGMGG-RASVSRRK--DSYGG--------PPLREPLPSRRDV-----YLSPSDDGYS
IKDS--------------------------------------------------------
-------------------------------------------------YS---------
------------------------------------------SRDYYPSYCDTRDYAPL-
PR---DYIYRDYNHSS-SCDNSP-SRGY------GDRDGYGRD--HDHS-DDPSGGSYKD
S--YESCG----------------------------------------------------
------------------------------------------------------------
-DSRSLPPIQGLPPFY----GV--SSCYDDNSS-SCDD-----------------C----
YSN------SR-SDLYSSERGLPPFMESGYPP-PLDS-----------------------
YSSSSRGA-TRG--DGHGGS-------------RSDRGGG---RSRY-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESGGRRGPPPP-PRSRGPPR--GLRGAR-G--GS-GAR---
-----------------GPPSRGSHL---------------G--------SSRGPLP---
----MKRGPP---PRSG-GPPPKRSAPS---------------------------GPV RS
S---SMGG-RAPVSRGR--DGYGG--------PPRREPMPSRRDV-----YMSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------GYSSRDYPSSRDTRDYAPP-
PR---DYAYRDYGHSS-SRDEYP-SRGYSLSSYS-DRDGYGGGRDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPARGPPP----SYGG--SSRYDDYGS-TRDG---------YG-SRESYSS---
-SRSDVYSSGR-DRVGRQDRGLPPSMERGYPPP-RD-----------------------S
YSSSSRGA-PRG--GGRGG------SRSDRG---------------GG--RSR------Y
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MMEADRPEKLF--------IGGLSLKTDE
----KALKAEFGKYGRIIEV-FLM----KDRETNKS-RGFAFIIFESPADANAAARDMNG
KYLDGKAI-KVALAIKPAFKSSRWV---PP-TPGSGG----RSRFS---HGTSGGGS---
--------------SPQQSPSRGGPDD-GRGYAGYFD---LR--------PYRALMP---
----RKRGP----SWHWASPPHKRAAPS---------------------------SLAR-
SIGGGMRG-KAPTMSGR--DGYSGLQRPHWAGAPRKRAAPPSSLAHIGGNGMPGKA----
------------------------------------------------------------
-----------------------------------------PALWGQDGYS---------
---------------------------------------GPPVREPLPPCRDPGDFVPA-
LR---EYSRRYYGHSS-VPDYHP-LGGD------GNQNGYRG-RDHDYA-GHPSKGSYRE
P--LESYG----------------------------------------------------
------------------------------------------------------------
-GPCGGAPGWGKPPSY----GG--GCRYEEYQG-HSPD---------AYSGDCSY-----
-------------------EALPVTLPDASSGD---------------------------
--RSP-KA-YSG---GRGGS-------------SNGYGR----SDRYGE-----------
-------------------------GRYKEYRGYS---------LDANSGGRSPDTYSGG
H----NSSSWSNRYRGGGHYEEYRGRSLDANS-RGHWPDAYSGGHGSSSQSNRYGGGGRY
KEYRGRSLDANSGRYSP------------------------------------------D
AYSRGHDSSSR----YGGGGLSEENRGHSLDANSRGRSPDA-YSGGHDSSSWSDRYGGGG
RYKEYRGHLLDANSGGRSPDAYSRGHDSSSWNNRYGGGGRYDN-RGHSLDANSGGHSPDA
HTHSGGHDSSSWSDHYRGGDHYEEYQGCSLDANSGGHSPDTYSRGHDS------------
--------------------SSWSDRYRGGGRYEEYQGCSLDANSGGHSPDTYSGGHDSS
TWSHCYGGGDCYEENRGHSLDANSGGH-SPEAYSGGRDSSSNSYDSSNSYEQSHCYG---
-----------------------------------------------------GEGEGYY
EEYRGPSPDAYSGGRDS--SSNSYEQSHRYGGEG-YYEEYRGPSPDAYSGGRDSSIKSYG
LSDRYGGGGRYEEYRGSLPDTYSGGRNRSSNSYGRSNRYLRGQDRVGRPDCGLPLPMERG
SPPLHDSYSRSGCRVPRGGGRQGGRLERGEGWSRY

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------VS-STKSNLNLQ---SL--------KSRSAVP---
----FSSGPQ---LSQEERN---RQKRP---------------------------SIFFH
Q--QSLHR-KAPVSRGR--DSYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYAPP-
PR---DYTYRDYGHFS-SRDDYP-SRGYG------DRDGYG--RDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRG--------------SRYDDYSS-SCDG---------YGGSRDSYSS---
-SRSDLYSSGH-DHVGRQERGLPPSMERRYPPP-RDS-----------------------
YSSSSRGA-PRG--GGSGGS-------------RSDRGGG---RSRY-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEG-EVMIIKKVNRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RRGPPPP-PRSRGPPR--GLRGGR-G--GSGGTR---
-----------------GPPSHGGHMD-DGGYSMNFN---MS--------SSRGPLP---
----VKRGPP---PRSG-GPPPKRSAPS---------------------------GPVR S
S--SGMGG-RAPVSRGR--DSYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYAPP-
PR---DYTYRDYGHSS-SRDDYP-SRGYS------DRDGY--GRDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGPPP----SYGG--SSRYDDYSS-SRDG---------YGGSRDSYSS---
-SRSDLYSSGR-DRVGRQERGLPPSMERGYPPP-RD-----------------------S
YSSSSRGA-PRG--GGRGG------SRSDRG---------------GG--RSR------Y
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MMEADRPEKLF--------VGGLNLKTDE
----KALKAEFGKYGHIIKV-FLI----KDRKTNKS-RGFAFVTFESPADAKAAARDMNG
KYLDGKAI-MVAQTIKPAFESSRWV---PP-TPGSGS----RSRFS---HRTRGGGS---
--------------SPQRPPSQGRPDD-GRGYVGYFD---LW--------PYRAPMP---
----RKRGPP---PRHCASPPHKRATLW---------------------------SLAH-
SVGCGMRG-KAPTVSGQ--DGYSGLQPRRWACPPRKRAAPRSSLARIGGSGMPGKA----
------------------------------------------------------------
-----------------------------------------PAVWGQDGYS---------
---------------------------------------GPWVREPLPPCRDPGDFVPA-
LR---EYSRRYYGHSS-VPDYCP-LRGD------GNRNGYRG-RDHDYM-DHPSKGSYRE
P--LKSYG----------------------------------------------------
------------------------------------------------------------
-GPCGAAPVRGTPPSY----GG--GCCYEEYQG-NSPD---------ACSEGRSS-----
-------------------EALPVVLPDAYSRD---------------------------
--HLP-KA-YSG---GRSSS-------------SNSYSR----SDRYGEEGCYEEYRGRS
PDAHSGGRNSSSNSYGQSHHYGG-EGRYEEYRGRSHEARSGGRSTDAHSGGRSDNAYSGG
H----DSSSWSDCCGGGGRYEEYQGRSLDANS-GGRSPEAYSGGHDNSSWSDRYGVGGHY
EENRGHSLDANSGGRSPDTHSGGRSSSSNSYGQSHRYGGEGHYEYRGRSHDAHSGGCSAD
AYSGGHDSSSRSHRYRGGGGCYEEYRGRSLDANSGGRSPNA-YSGGHDSSSRSHRYGGGG
CYEEYRGRSLDANSGGRWPDAYSGGHDSSSQSNRYGGGGCYEEYRGRSLDANSGGCSPNA
--YSGGHDSSSQSHRYGGGGRYEEYQGRSLNANSGGHWPDAYSGGHDSSSQSNRYGGGGR
SLDANSGGRSPDAYSGGHDSSSQSNRYGGGSRYEEYRGRSLDANSSGRLPDAYSGGHDSS
SWSHRYGGGGRYEEYRGRSLDANSGGR-SPNAYSGGRDSSSNSYDRSHRYGGGGHYEEYR
GRSHDTHSRGQSPDAHSGDRSTEAYSRGRNSFSN------------SYGQSDHYGRGGRY
EEYQGRSPDAYGGGRGLNSSNNSHGRSHRYGGGGR-YEEYRGPSPDAHSGGHDSSIKSYG
LSDRYGGGGHYEEYQGSLPDAYSGDHDRSSNSYGRSDRYSRGRDRVGRPDRGLPLPMETG
SPPLHDSYSRSGCRVPRGGGRQGGRFERGEGQSRY

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKSD-IPALCSL--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RRGPPPP-PRSRGPPR--GLRGG---RGGSGGTR---
-----------------GPPSRGGHMD-DGGYSMNFN---MS--------SSRGPLP---
----VKRGPP---PRSG-GPPPKRSAPS---------------------------GPVR S
S--SGMGG-RAPVSRGR--DSYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYAPP-
PR---DYTYRDYGHSS-SRDDYP-SRGYS------DRDGYG--RDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-HYIMTKGSIQQEDF-TI------------LNI-FAPN---------TGE--PRFIT---
-QL-----------------------LLGLG-K-DLD-----------------------
------------------S------H-------KIIVG-----DFTIPLTALD------R
SSRQ-------KTNK---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KXXXXXXX-X XXXXXXXXXXXX-XXXXXX--XXXXXXXX--XXLRGG-G--GSGGTR---
-----------------GPPSRGGHMD-DGGYSMNFN---MS--------SSRGPLP---
----VKRGPP---PRSG-GPPPKRSAPS---------------------------GPVR S
S--SGMGG-RAPVSRGR--DSYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYAPP-
PR---DYTYRDYGHSS-SRDDYP-SRGYS------DRDGY--GRDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGPPP----SYGG--SSRYDDYNS-SRDG---------YGGSRDSYSS---
-NRSDLYSSGR-DRVGRQERGLPPSMERGYPPP-RD-----------------------S
YSSSSRGA-PRG--GGRGG------SRSDRG---------------GG--RNR------Y
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MMEVNQPGKLF--------IGGLSREANE
----KTLKAVFGKHGPLSEV-FGR----KDR-KTSC-RGFAFITLQIAKNAAKDMN GGKI
LFLYGKAI-KVEQANKPSFQSGGTRRISPP-SRHRSPLG--SLKSI---RNSSGGTR---
----------------GRHHSRGRHLG-DGGYTLDLH---MS--------SSRGTFG---
----VKRGPS---SRIG-SPPPKKSAPS---------------------------TVAR-
S -NGGMGG-QGRMSRGR--ESYAG--------PLRREPF-SWRNDST-----SPRDDAYA
TKDSTSLLTQAF----NP----LFC-----------------------------------
-------------------------------LG----------------CF----HCSIS
RHKYYCKRVMFWILEVDHL----------------KFVSLTYASRNHPSFRDTRCYSPP-
RK---DYAWCDYGRS--RRDEHS-SRGY------GEHDG----RDRDDS-GHPSRCSYRD
A--YQR------------------------------------------------------
------------------------------------------------------------
-TSRGAAPAPAPRMTF----GG--SSR-HDYNN-TRDR---------YDRSRESYS----
RSRGDFYSSGR-EHSGRKERTYPPSVDRVRRDPH-EE-----------------------
CGSSSYRA-SRK---GVGE-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADCPGKLF--------IGGLNKETNE
----KMLKAVFVKHGPISEV-LLI----KDR-TSKS-RGFAFITFENPADAKNAAKDMNG
KSLDGKAI-KVEQAKKPSFQSGGKRRPPPS-SRNRNPSG--SLRSA---KGSSGGIR---
----------------GWLPSHEGHLD-DGEYTLDLN---MS--------SSRGAIP---
----VKRGPS---SRSG-GPLPKKSALS---------------------------AMAR-
S -NSWIRS-QGPMSRGR--ENYGG--------PPCREPTSSWRNDHM-----SRRDDGYA
TKDDEIHITKLNITRYSVSCN---NYLHQVP-----KHFHHSIY----------------
---------------------LNHSK---LKLQLPVKQS--LPFSS---FPQLLANTNLC
CSFT----GCVWEIDTHFGFEMHFLHPLTCNAHVPQNLKYKKNKKNHPSSRETRDYAPP-
PK---DYAYCVYGRS--SRDEHS-SRGY------SDRDGYSEVRGRDHS-EGPSGSSYRD
A--FQPAG----------------------------------------------------
------------------------------------------------------------
-TSHGAPPAQGPQMSY----GG--STC-HDY-N-TRVR---------YGRSWESYS----
RSCGDSYSCGR-EHAGRKDQRNLPSLDRLLPAPR-EA-----------------------
YGSSSYVS-STV---DGEES-------------RSEKED----LSRY-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVVADCLGKFF--------IVGLNTETNE
----KALEAPFVEVLLMK-----------DREANKS-RGFAFVTFESPADAKDAARDMN G
--------------------NG-RRGPPPL-PRSRGPPR--GLRGG---RGGGGGTR---
-----------------EPPSWGGLMD-DGGHSMHFN---TS--------SSREPLP---
----VKREPS---PRSG-GPSPKRSAPS---------------------------GPVH S
S--SGVGG-RAPLSHGR--ESYGG--------PPRRELLPSRRDV-----YLSPRDDVYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SSSSRDYPSSRDTREYAPP-
SR---DYTYHDYGHSS-SRDDHP-SRGYS------ERDGYD--RDHDYS-DHPSGSSYRD
S--YESYD----------------------------------------------------
------------------------------------------------------------
-NSHSAPPTQGPPPFY----AG--NSLYHDYSS-SHDG---------YGRSQDSYSS---
-SRSDLYSSL-----GRQERGLLASLERGYLSP-RDS-----------------------
YNSSSCRA-SRG--GGHGG------R------------GG---RSSY-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

------------------------------DMVEADRPGKLF--------IGGLNPETDE
----KGLEAAFGKYGRISEV-LLM----KDRETSKS-RGFAFVTFESPADAKAAARDMNG
KSLDGKAI-KVAQ-----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------XPPPLRRDP-----YLGPREEGYS
PRD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------GYSSRDYP-----REFAPS-
PR---EYTYRDYGHAS-ARDDCP-SRGYG------DRDGYG-GRDRDYA-DHPSGGSYRD
P--FESYG----------------------------------------------------
------------------------------------------------------------
-DPRSAATARGPPPSYG---G---GGRYDDYRG-CSP--------DVYGGGRNGYGG---
-GRSDRYSRGR-DRVGRADRGLSPSLERGCPPP-RDS-----------------------
YSRSGRRI-PRG--GGRLGS-------------RPERGGG---RS--RY-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------VGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETSKS-RGFAFITFESPADAKDAARDMNG
KLLDGKSI-KVEQATKPTFESGGRRGPPPP-PRSRGPPRGLRGGGR---GGSGGGTR---
-----------------GPPSRGGHMD-DSGYSLNFN---MG--------SSRGPLPVKR
G------PPP---RSGG-GPPPKRSAPS---------------------------GPVRS
SSGMGGRX-XXXXXXXX--XXXXX--------XXXXXXXXXX--X-----XXXXXXXXXX
XXXX--------------------------------------------------------
-------------------------------------------------XX---------
-------------------------------------------XXXXXX-XXXXXXXXX-
XX---XXXXXXXXXXX-XXXXXX-XXXX------XXXXXXXXXX-XXXX-XXXXXXXXXX
X--XXXXX----------------------------------------------------
------------------------------------------------------------
-XXXXXXXXX-X--XX----XX--XXXXXXXXXXXXXX---------XXXXXXXXXX--X
XXXXXXXXXXX-XXXXXXXXXXPLSMDRGYPP-PRDS-----------------------
YSSSSRGA-PRG---GRGGS-------------RSDRGGG---RSRY-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MMEADHPEKLF--------VGGLNLKTDE
----KALKAEFGKYGHIIKV-FLM----KDRKTNKS-RGFAFVTFESPADAKAAARDMNG
KYLDGKAI-MVAQAIKPAFKSSRWV---PP-TPGSGS----RSRFS---HRTRWGGS---
--------------SPQRPPSQGGPND-GRGYAGYFD---LW--------PYRAPMP---
----RKRGPP---PRHWASPPHKRAMPS---------------------------SLAH-
SVGCGMRG-KAPTVSGQ--DGYSGLQPRRWAGPPRKRAAPRSSLARIGGSGMPGKA----
------------------------------------------------------------
-----------------------------------------PAVWGQDGYS---------
---------------------------------------GPRVREPLPPCRDPGDFVPA-
LR---EYSRRYYGHSS-VPDYRP-LRGD------GNRNGYRG-RDRDYT-DHPSKGSYGE
P--LKSYG----------------------------------------------------
------------------------------------------------------------
-GPCGAARVRGTPPSY----GG--GCRYEEYQG-NSPD---------ACSEGRSS-----
-------------------EALPVVLPDAYSRD---------------------------
--HSP-KA-YSG---GCSSS-------------SNGYSR----SDRYREEGCYEEYRGRS
PDAHSGGRNSSSNSYGQSHHYGG-EGRYEEYRGRSHEARSGGRSTDAHSGGRSDDTYSGG
H----DCSSWSDCCGGGGRYEEYQGRSLDANS-GVRSPEAYSGGYDNSSWSDRYRVGGHY
EENRGHSLDANSGGRSPDTHSGGCSSSSNSYSQSHRYGGEGRYEYRGRWNDAHSGGCSAD
AYSGGQDSSSQSNHY-GGGGCYEEYRGRSLDANSGGRSPDA-YSGGHDSSSQSNRYGGGG
RYEEYRGHLLDANSEGRSPDTYSRGHDSSSQSDHYGGGG-------RSLDANSSGRLPDV
--YSGGHDSSSRSHRYRGGGRYEEYRGRSLDVNSGGRSPDAYSGGHDSSSQSNRYGGGGR
SLDANSGGRWPDAYSGGHDSSSQSNCYGGRGHYEGYRGRSLDANSGGRSPNGYSGGHDSS
SRNDPCGGGGRYEENRGHSLDANSGGH-SPNTYSGGRDSSSNSYDRSHRYGGGGHYEEYR
GRSHDTHSRGQSPDAHSGDCSTEAYSRGRNSFSN------------SYGRSDHYGRGGRY
EEYRGRSPDAYGGGRGLNSSNNSHGRSHRYGGGGRCYEEYRGPSPDAHSGGRDSSIKSYG
LSDRYGGGGHYEEYQGSLPDAYSGDHDRSSNSYSRSDRYSRGRDRVGRPDRGLPLPMETG
SPPLHDSYSRSGCRVPRGGGRQGGRFKRGEGRSRY

-------------------------------MFEADHPGKLF--------FSGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDPETNKS-GGFAFVTFE------DAARDMNG
KSLDGKAI-KVEQVTKPSFESG-RRGPPPP-PRSRGPPR--GLRGG---RRG--------
------------------------------------------------------------
----VKRGPP---PKNG-GPPPKRSALS---------------------------RPVSS
S--SGKGG-RAPV---------SR--------PLGREPLPSSRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTR------
----------DYGHSS-SRDDYL-SRGYS------DRDGYG--RDRDYS-DHPSGVSYRD
A--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSALPTRGPPPSY----GG--SSPYDDYSS-SRDG---------Y----DSHSS---
-SQSDLYSSGR-DRVGRQERGLHSSMERGYPPP-RDS-----------------------
YSSSSCGA-PRD--GGRGG------R------------GG---RSRY-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDCETNKS-RGFAFVTFESPADAKDAAIDMNG
KLTLPIPI-LTFYTKEAES-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADHPGKLF--------IGGLNRETNE
----KMLKAVFGKHGPISEV-LLI----KDR-TSKS-RGFAFITFENPADAKNAAKDMNG
KSLHGKAI-KVEQAKKPSFQSGGRRRPPAS-SRNRSPSG--SLRSA---RGSRGGTR---
----------------GWLPSHEGHLD-DGGYTPDLK---MS--------YSRGLIP---
----VKRGPS---SRSG-GPPPKKSAPS---------------------------AVAR-
S -NSWMGS-QGPMSQRR--ENYGV--------PPRRATISSWRNDRMS-----TRHDGYA
TNDGNHPSCQ-ETRDYAP---PSRGYAYRDNGHSNRDEHSSRGYRNHRSSRETRDYAPPS
RGHAYRDYGHSRRDESYSRGYRNRRSSRETREYAPPSRG--HGYRD---YGHSRRHESYS
RGYR-----------------------------------------NHPSSRETRDYAPP-
HR---DYAYRDYGHS--SWDEHS-SRGY------SYHDGYGEALGRDHS-EHLSGSSYRD
A--LQRYG----------------------------------------------------
------------------------------------------------------------
-TSHGAPPARGPRMSY----GG--STC-HAYSN-TRDR---------YGRSWESYS----
-SCGDFHYCDR-EHVCRKDQRNPPSLGRVLPDPR-EA-----------------------
CGSSSYVA-SIV---DGGES-------------RSEKGD----SSRY-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------------PGKLF--------IGRLNTETNE
----KALEAVFGKYGQIVEV-LLM----KDRETNKS-RGFAFVMFETPADTKDAVRDMNG
KSLDGKLLYHVEEIVTEVHLEENCCLLVEM-FICPQEMMGILLKTV---IPAEITQVLMI
PEIMHHDHEIILTVTM-VIPVHVMTIH-QEAIAIEMD---MVVIVTIQIIQVEVPTEIHM
RVMLT-HVVL---HLHE-GPLASHVHFSLQFSN-----DI--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

------------------------------KMVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RRGPPPP-PRSRGPPR--GLRGGR-G--GSGGTR---
-----------------GPPSRGGHMD-DGGYSMDFN---MT--------SSRGPLP---
----VKRGPP---PRSG-GPPPKRSAPS---------------------------GPVR S
S--SGMGG-RAPVSRGR--DSYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYAPP-
PR---DYTYRDYGHSS-SRDDYP-SRGYS------DRDGY--GRDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGPPP----SYGG--SSRYDDYSS-SRDG---------YGGSRDSYSS---
-SRSDLYSSGR-DRVGRQERGLPPSMERGYPPP-RD-----------------------S
YSSSSRGA-PRG--GGRGG------SRSDRG---------------GG--RSR------Y
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MIEADRPGNLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNA
KSFDGKTI-KVEQATKPSFESG-RRGPPPP-PGS----R--GLRGGR-G--GSGGTR---
-----------------GPPSRGGHMD-DGGYSMNFN---MS--------SSRGPLP---
----VKRGPP---PRSG-GPPPRRSAPS---------------------------GPVH S
S--SGMGG-RAPVSRGR--DSYGG--------PPRRELLPSCRDD-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYAPP-
PR---DYTYRDYGRSS-SRDDYS-RY----------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------DDYSS-SRD---------GYGGSPDSYSS---
-SRSDLYSSGR-DRVGRQERGLPPSMERGHLPP-RD-----------------------S
YSSSSRGA-PRG--GGRGG------S-----------RSD----RGGG--RSR------Y
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

------------------------------MVLAHCRPGKFF--------IGGLNTETNK
----KALEAVFGKYGRIVEA-LLM----KDHETNKS-RGFAFVSFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RRELPPP-PRSRGPPK--GLRGG---RGGSGGTR---
-----------------GPPSWRRHMD-D-------------------------------
----VKRRPP---PRSW-DPPPKRSASS---------------------------GPVR S
S--SVMGG-RAPVSR-----------------PPGKEPLPSHRDA-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SSSSRDYPSSHDT-------
-R---DCTYRDYGYFS-SRDDYP-SRGYS------DRDGYS--RDHDYS-DHPTGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSHSAPPTRGPPNLM------------VEVMI-IA------------VHVMDMVEV---
-TQAAKV---------------------ISNQV-VMIGLAVKKEG------FPLLWKSSM
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MAEADRPGKLF--------IGGLSAETDE
----KGLEATFGKYGRIIEV-LLM----KDRETSKS-RGFAFVTFESPADAKAAVRDLNG
NCFVFCEIPVNFLSPFYAFERKMVKTRLIL------FGI--VK-------SF--------
------------------FQQAHVKSM-T-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

--------------------------------VEANRPGKVF--------VGGLSTETNK
----KALEAVFGKYGRIVEA-LLR----KDHETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RRGLPPP-PRSRGPPR--GLRGG---RGGR-------
------------------EPSRGRHMD-DGGYPMNFN---MS--------SSRGPLP---
----VKRGSP---LRSG-SPPPKTSAPS---------------------------GPVH S
S--SGMGG-RAPVSRGR--DSCGD--------PPRREQLPSGRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYPSRDYPSSRDTRDYAPP-
PR---DYTYCDYGHFS-SHGDYP-SRGYS------DRDGYS--RDC----------SYRD
S--HESYG----------------------------------------------------
------------------------------------------------------------
-NSGSAPPTRGPPCGY------------DDYSS-SPDR---------Y----DSYSS---
-SQSDLYSSGG-DRVGRQERG--RGALRGGGHG-GS--QSDRGGGRSR---Y--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MMEADRPEKLF--------VGGLNLKTEE
----KALKAEFVKYGRIINV-FLM----KDRETNKS-RGFAFVTFESPADAKAAARDLNG
K-----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RRGLPPP-PRSRGPPR--GLRGGR-G--GSGGTR---
-----------------GPPSRGGHMD-DGGYSMNFT---LS--------SSRGPLP---
----VKRGPP---PRSG-GPPPKRSAPS---------------------------GPVR S
S--SGMGG-RAPVSRGR--DGYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYAPP-
PR---DYTYRDYGHSS-SRDDYP-SRGYS------DRDGY--GRERDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGPPP----SYGG--SSRYDDYSS-SRDG---------YGGSRDSYTS---
-SRSDLYSSGR-DRVGRQERGLPPSMERGYPPP-RD-----------------------S
YSSSSRGA-PRG--GGRGG------SRSDRG---------------G---RSR------Y
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MIEADRPGKVF--------IGGLSTETSK
----KALEAVFGKYGRIVEA-LLR----KDHETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKLSFESG-RGGLPPP-PRSRGPPR--GLRGG---RGGR-------
------------------EPSRGRHMD-DSGYSMNFN---MS--------SSRGPLP---
----IKGGPP---LRSG-SPPPKTSAPS---------------------------GPVR S
S--SGMAG-RAPVSCGR--DSYGD--------PPRREQLPSGRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYAPP-
PR---DYTYRDYGHFS-SHGDYP-SRGYS------DRDGYS--RDC----------SYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSGSAPPTRGPPCGY------------DDYSS-SPDR---------YGGSRDSYSS---
-SRSDLYSSGG-DRVGRQERGLPPSVEILNVIP-TAIHFLGHQGLRAPPLHR--RHPPFG
VFSEKKLV----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

---------------------------------EADRPRKLF--------IGGLNIETNE
----KVLEAVF------VEI-LLM----KHHETNKS-RGFS-------------------
--LDGKSI-KVEQATKPSFERWSCWHGPPLPQRSGDPPR--DLRGG------SGGTM---
-----------------GPPSRGGYMD-NGSYSMNFN---MR--------PP--------
-------------PQSC-SPPPVRSMPS---------------------------DPV--
RSSSGMGG-RASVSRRK--DSYGG--------PPLREPLPSRRDV-----YLSPSDDGYS
IKDS--------------------------------------------------------
-------------------------------------------------YS---------
------------------------------------------SRDYYPSYCDTRDYAPL-
PR---DYIYRDYNHSS-SCDNSP-SRGY------GDRDGYGRD--HDHS-DDPSGGSYKD
S--YESCG----------------------------------------------------
------------------------------------------------------------
-DSRSLPPIQGLPPFY----GV--SSCYDDNSS-SCDD-----------------C----
YSN------SR-SDLYSSERGLPPFMESGYPP-PPDS-----------------------
YSSSSRGA-TRG--DGHGGS-------------RSDRGGG---RSRY-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGFNTETNE
----KALEAVFGKYGLIVEV-LLM----KDRESNKS-RGFAFVTFESPADAKDAAWDMNG
KSLDGKM-------------------------------MDIPLKTA---IQTEITQVLMI
QESMPHHQEIILTVIM-VIPVHVKTIH-QEAIVIEMA---MVGIVTIQTT----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADHPGKLF--------IGGLNTETSE
----KALEAVFGP------------------ETNKS-RGFAFVTFESPADAKNAARDMNG
KSLDGKAI-KVEQATKPSFESG-RRGLPPP-PRSRGPPR--GLRGG---RGGSGGTR---
-----------------G-----RHMD-DGGYLMNFN---MS--------SSRGPLP---
----VKRGPP---PRSG-GPPPERR-------------------------------PVR S
S--RGMGG-RAPVSRGR--DGYGG--------PPRR-------DV-----SLSPRDDGYS
-KD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------TYSSRDCPSSRDTRDHAPP-
PR---GYTYRDCDHSS-SRDDYP-SRGYG------DRDGCG--RDRAYQ-SIPASCVSIL
K--IPVY-----------------------------------------------------
------------------------------------------------------------
---------VPVHKFYVLVRKK--S-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-K VEQATKPSFESG-RRGPPPP-PRSRGPPR--GLRGGR-G--GSGGTR---
-----------------GPPSRGGHMD-DGGYSMNFN---MS--------SSRGPLP---
----VKRGPP---PRSG-GPPPKRSAPS---------------------------GPVR S
S--SGMGG-RAPVSRGR--DSYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYAPP-
PR---DYTYRDYGHSS-SRDDYP-SRGYS------DRDGY--GRDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGPPP----SYGG--SSRYDDYSS-SRDG---------YGGSRDSYSS---
-SRSDLYSSGR-DRVGRQERGLPPSMERGYPPP-RD-----------------------S
YSSSSRGA-PRG--GGRGG------SRSDRG---------------GG--RSR------Y
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MIEADRPGNLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNE
-----ELLYHVEEIVTEVHLEGNRCPLVEM-IICPQEMMGILLKTA---IQAEITQVLVI
LEIMHHHHEIILTVIT-VAPVHVMTSH-QEAIAIEMD---MVVIVTIQIIQVEVPTEIHM
RVMVT-HIVL---HLHE-GPCPILWWKQSL------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNLETDE
----KALEAAFGKYGRIIEV-LLM----KDRETSKS-RGFAFVTFENPADAKAAARDMNG
KSLDGKAI-KVAQATKPVFESGRRGPPP---PRSRGRPR--GLRGT--------------
------------------------------------------------------------
------------------------------------------------------------
--------------------GYGG--------PSRRELPPPRRDP-----YLGPRDEGYS
PRE---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSARDPRDFAPS-
PR---DYTYRDYGHSS-ARDECP-SRGYC------ERDGYG-GRERDYGGEHPSGGSYRD
P--FDSYG----------------------------------------------------
------------------------------------------------------------
-DPRGAGPARGPPPSYG---G----GRYEDYRG-CSP--------DGYGG-RDSY-----
--RSERYSSGR-ERVGRPERGLPPSVERSCPTP-RDS-----------------------
YSRSGRRAPPRG--GGRVGS-------------RLERGGG---RSRY-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALETVFGKYGRIVEV-LLI----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKLLYHVEEIVTEVHLRRE-----PM-FICPQEMMGILLKTA---IQAEITQVLVI
QEIMHHHHEIILTVIM-VIPVHVMTIH-QEAMAIEMD---MVVIVTIQIIQVEVPTEIHM
RVMIV-EDCA---HYGC-G---VLIDSQ--------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPWGRL--------XXXXXXXXXX
----XXXXXXXXXXXXXXXXXXXX----XXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXX
XSLDGKAI-KVEQATKPTFESG-RRGPPPP-PRSRGPPR--GLRGGR---GGSGGTR---
-----------------GPPSRGGHMD-DGGYSMNFN---MS--------SSRGPLP---
----VKRGPP---PRSG-GPPPKRSAPS---------------------------GPVRS
S--SGMGG-RAPVSRGR--DSYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDARDYAPP-
PR---DYTYRDYGHSS-SRDEYP-SRGYS------DRDGYG--RDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGPPPSY----GG--SSRYDDYSS-SRDG---------YGGSRDSYSS---
-SRSDLYSSGR-DRVGRQERGLPPSMERGYPPP-RDS-----------------------
YSSSSRGA-TRG--GGRGGS-------------RSDRGGG---RSRY-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRLGKLF--------IGGLNTETNE
----KALEAIFV------EV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RRGPPPP-PRSRGPPR--GLRGGR-G--GSGGTR---
-----------------GPPSRGGHMD-DGGYSMNFN---MS--------SSRGPLP---
----VKGGPP---PRSG-GSPPKRSAPS---------------------------GPVR S
S--SGMGG-RAPVSRGR--DSYRG--------PPRREPLPSHRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYAPP-
PR---NYTYRDYGHSS-SRDDYP-SRGYS------DRDGY--GRDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSHSAPPTRGPPP----SYGG--SSRYDDYSS-SRDG---------YGGSRDSYSS---
-SRSDLYSSGR-DRVGRQERGLPPSMERRYPPP-RD-----------------------S
YSSSSRGA-PRG--GGRGG------SRSRY------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

----------------------------MKIQVEADRPGKLY--------VGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDREINKS-RRFAFVTFESPADAKDAARVMNG
KSLDGKAI-KVEQATKPSFESS-RRGLPPP-PRGRGPPR--GLRGGR-G--GSGGTR---
-----------------GPPSWGGHMD-DGGYSMNFN---MT--------SSRGPLS---
----VKRGPP---PRSE-GPPPKRSSPS---------------------------GPVG S
S--SGMGG-RAPVSRGR--DSYGG--------PPRREPPPSRRDV-----YLPPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------N-----YPSSCDTRDYAPP-
PR---DYTYCDYGHSS-SRDDYT-SRGYS------DRDGY--GRDHS----------YRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSHSAPPTRGPPP----SYGG--SSHCDVYSG-SRDR---------YGGSRDSYSS---
-SQGDLYSSGR-DRGGRQERGLPPSMERGYPPP-RD-----------------------S
YSSSSCGA-PRG--GGRGG------SRSDRG---------------GG--RSR------Y
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEVDLPGKLF--------ISGLNTETNE
----KALEAVFGKY---------M----KDRETNKS-KGFAFVIFESPADAKDTARDTNG
KSLDGKAI-KVEQATKPSFESS-RHEPPPP-LRSRGLPR--GLRGG---RGGSGGTR---
-----------------RPPSRGGHM---------------S--------SSRGPLP---
----VKRR------LCG-STPPKRSAAL---------------------------GPVR S
S--SGMGG-RAPVSCRR--DSYGG--------PPRRELLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPDSRDTRDYAPP-
PR---DYTYRDYGHSR-SHDVYL-SRGYS------VRDGYG--PDRDYS-DHASGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-ISRSAPPTRGPPPSY----GG--SSYYDDYRS-SRDG---------YGGSQH--SS---
-SRSDLYSSGP-DQVGRQERGLPPSMERRYPPP-RDS-----------------------
YSSSSCRA-PRG--GGHGG------S-------RSERGGG---RNRY-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MFEADHPGKLF--------FSGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDPETNKS-GGFAFVTFE------DAARDMNG
KSLDGKAI-KVEQVTKPSFESG-RRGPPPP-PRSRGPPR--GLRGG---RRG--------
------------------------------------------------------------
----IKRGPP---PKNE-GPPPKRSALS---------------------------RPVSS
S--SGKGG-RAPG----------G--------PLGREPLPSSRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTR------
----------DYGHSS-SRDDYL-SRGYS------DRDGYG--RDRDYS-DHPSGVSYRD
A--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSALPTRGPPPSY----GG--SSPYDDYSS-SRDG---------Y----DSHSS---
-SRSDLYSSGR-DRVGRQERGLHSSMERGCPPP-RDS-----------------------
YRSSSCGA-PRD--GGLGG------R------------GG---RSRY-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------ICGLNTQTSE
----KTLEVVFGKYGRIVEV-LLM----KQT----D-RGFAFVTFESPGDDKDAARDMYG
KSLDGKAI-KVEQTTKPSFESG-RRGP--L-HRSRGPPR--GLRGG---RGGSGGTR---
-----------------RPPSRGGHM--------NFN---MS--------SSRGLLP---
----VKRGPP---LRSG-SPPPKRSALS---------------------------GPVL S
S--SGMGG-RAPVSRGR--DSYRG--------PPRREPLPSHRDI-----YLSPRDDVYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYCSRDYPSSRDTRDYTPP-
PQ---DYTYRDYGHSS-SHDDYP-SKCYG------DREGYG---DRDYS-DHPNGGSYRD
S--CESYG----------------------------------------------------
------------------------------------------------------------
-NSRSARPTRGPPPAY----GG--SSCYDDYSS-SCDG---------YGGSQT-------
--------------VTQQERGLPPSME-GYPPP-RDS-----------------------
YSSSSHGA-P----GGRGG------R-------QSDRGGG---RSRY-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RRGPPPP-PRSRGPPR--GLRGGR-G--GSGGTR---
-----------------GPPSRGGHMD-DGGYSMNFN---MS--------SSRGPLP---
----VKRGPP---PRSG-GPPPKRSVPS---------------------------GPVR S
S--SGMGG-RAPVSRGR--DSYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYAPP-
PR---DYTYRDYGHSS-SRDDYP-SRGYS------DRDGY--GRDRDYS-DHPSGGSYRD
S--YDSYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGPPP----SYGG--SSRYDDYSS-SRDG---------YGGSRDSYSS---
-SRSDLYSSGR-DRVGRQERGLPPSMERGYPPP-RD-----------------------S
YSSSSRGA-PRG--GGRGG------SRSDRG---------------GG--RSR------Y
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADHPGKLF--------IGGLNRETNE
----KMLKAVFGKHGPISEV-LLI----KDR-TSKS-RGFAFITFENPADAKNAAKDMNG
KSLDGKAI-KVEQAKKPSFQSDGRRRPPAS-SRNRSPSG--SLRSA---RGSSGGTR---
----------------GWLPSHEGHLD-DGGYTPDLN---MS--------YSRGLTP---
----VKRGPS---SRSG-GPPPKKSAPS---------------------------AVAR-
S -SSWMGS-QGPMSQRR--ENYGV--------PPRRGTISSWRNDRMS-----PRYDGYA
TNDGNHPSCQ-ETRDYAP---PSRGYAYRDNGHSNRDEHSSRGY----------------
---------------------RNHPSSRETRDYAPPSR-------D---YGHSRQDEHSS
RGYRYC--NFFWIYQIDF---------LYCSF---------QITLNSPSSRETRDYTPP-
PR---DYAYHDYGHS--SWDEHS-SRGY------SYHDGYGEALGRDHS-EHLSGSSYRD
A--FQGYG----------------------------------------------------
------------------------------------------------------------
-TSHDAPPARGPRMSY----GG--STC-HAYSN-TRDR---------YGRSWESYS----
RSCGDFHYCDH-EHVCRKDQRNPPSLGRVLPDPR-EA-----------------------
YGSSLYVA-SIV---DGGES-------------RSEKGD----SSRY-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNLETDE
----KALEAEFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKAAARDMNG
KSLDGKAI-KVAQATKPAFESSRRGPPP---PRSRGRPR--FLRGT---RGGGGGPR---
-----------------RSPSRGGPDD-DGGYAGDFD---LR--------PSRAPMP---
----MKRGPPPP--PRRAGPPPKRAAPS---------------------------GPARS
S -GGGMRG-RALAVRGR--DGYSG--------PPRREPPPPRRDP-----YLGPRDEGYS
SRD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDY---REPRGFAPS-
PR---EYTHREYGHSS-VRDDCP-LRGYG------DRDGYG-CRDRDYG-DHPSRGSYRE
P--FESYG----------------------------------------------------
------------------------------------------------------------
-DLRGGAPGRGTPPSYG---G---GGRYEEYRG-CSP--------DAYSGGRDSYSS--S
YGRSDRYSRGR-DRVGRPDRGLSLSMERGCPPQ-RDS-----------------------
YSRSGCRV-PRG--GGRLGG-------------RMERGGG---RSRY-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RRGPLPP-PRSRG---------LR-G--GSGGTR---
-----------------GPPSRGGHMD-DGGYSMNFN---MS--------SSRGLLP---
----VKRGPP---PRSG-GPPPKRSAPS---------------------------GPVR S
S--SGMGG-RAPVSRGR--ESYGG--------PPRREPLSSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYAPP-
PR---DYTYRDYGHSS-SRDDYPPSRGYS------DRDGY--GRDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSGPPARGPPP----SYGG--SSRYDDYSS-SRDG---------YGGSRDSYSS---
-SRSDLYSSGR-DRFGRQERGLPPSMERGYPPP-RDS----------------------S
YSSSSRGA-PRV--GGRGG------SRSDRG---------------GG--RSR------Y
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------PVSRGR--DSYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYAPP-
PR---DYTYRDYGHSS-SRDDYP-SRGYS------DRDGY--GRDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGPPP----SYGG--SSRYDDYSS-SRDG---------YGGSRDSYSS---
-SRSDLYSSGR-DRVGRQERGLPPSMERGYPPP-RD-----------------------S
YSSSSRGA-PRG--GGRGG------NRSDRG---------------GG--RSR------Y
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RRGPPPP-PRSRGPPR--GLRGGR-G--GSGGTR---
-----------------GPPSRGGHMD-DGGYSMDFN---MS--------SSRGPLP---
----VKRGPP---PRSG-GPPPKRSAPS---------------------------GPVR S
S--SGMGG-RAPVSRGR--DSYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYAPP-
PR---DYTYRDYGHSS-SRDDYP-SRGYS------DRDGY--GRDRDYS-DHPSGGSYRD
S--YESYG----------------------------------------------------
------------------------------------------------------------
-NSRSLSHSESKKI----KEYT--KILISAYIQ---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFITFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RRGPPPP-PRSRGPPR--GLRGGR-G--GSGGTR---
-----------------GPPSRGGHMD-DGGYSMNFN---MS--------SSRGPLP---
----VKRGPP---PRSG-GPPPKRSAPS---------------------------GPVR S
S--SGMGG-RAPVSRGR--DSYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
--------------------------------------------RDYPSSRDTRDYAPP-
PR---DYTYRDYGHSS-SRDDYP-SRGYS------DRDGY--GRDRDYS-DHPSGGSYRD
S--YESYGKIMVKGFDYHQLEFLGHEPVYVMCFPPTVKIQFKNFINKIKYLPLQYEGKST
VQKLQQLITGKWLSVYYKITSCLEYPLEIHTVFSLFKQTLKSIHFRISAVLPYYLTIDPA
GNSRSAPPTRGPPP----SYGG--SSRYDDYSS-SRDG---------YGGSRDSYSS---
-SRSDLYSSGR-DRVGRQERGLPPSMERGYPPP-RD-----------------------S
YSSSSRGA-PRG--GGRGG------SRSDRG---------------GG--RSR------Y
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

-------------------------------MVEADRPGKLF--------IGGLNTETNE
----KALEAVFGKYGRIVEV-LLM----KDRETNKS-RGFAFVTFESPADAKDAARDMNG
KSLDGKAI-KVEQATKPSFESG-RRGPPPP-PRSRGPPR--GLRGGR-G--GSGGTR---
-----------------GPPSRGGHMD-DGGYSMNFN---MS--------SSRGPLP---
----VKRGPP---PRSG-GPPPKRSAPS---------------------------GPVR S
S--SGMGG-RAPVSRGR--DSYGG--------PPRREPLPSRRDV-----YLSPRDDGYS
TKD---------------------------------------------------------
------------------------------------------------------------
----------------------------------------SYSSRDYPSSRDTRDYAPP-
PR---DYTYRDYGHSS-SLSIY--------------SDGY--GRDRDYS-DHPSGALC--
A--FSQQG----------------------------------------------------
------------------------------------------------------------
-NSRSAPPTRGPPP----SYGG--SSRYDDYSS-SRD---------GYGGSRDSYSS---
-NRSDLYSSGR-DRVGRQDRGLPPSMERGYPPP-RD-----------------------S
YSSSSRGA-PRG--GGRGG------SRSD---------------RGGG--RSR------Y
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------

Query Results

"ENSGT00710000106295_4"

ENSGT00710000106295_4