Query Results 

MWPGPALLLL----------GLGLGLGSQPPPTGPRGLPGVLRGAPGLGQG---------
------AESSV-------------QGGD------------------TGG------LS---
-------------------PRA-AP-----------------------------------
--------------------------------------RH---------ASPTPPRRCPS
GAAA--RVLLKVNSSDPAAAKANVSCQTP---PCIMQPVKI-NRKDQNAPLIL-SRDEEA
TLNI

PF02010 // ENSGT00700000104221_2_Domain_0 (305, 788)

TVRWYCPDALVIRKSWVYFSVASVND-TPDWNRPVLLPQVAV-SKGFSLHIPKYAL
PYGVYVFNFTLSIFRW-DLAWPTVTGSDIIYIWVKKRPLKAVL-LGAPRVTVKFSDELIL
NGSMSYDPEA---DIPTW--GLQFFWYCTTNPRYYSGNYVLVINQAVCHP-EQDSLNWPW
AVGSVLTIPPKTLRGNVVYYFRMVVQKQNRTAFSDKTVHVLQGLQPKAHISCIENCGPTL
GVSDRFSLFLNCPSCGR-Q-DLYSWSILSLTGHEVMFDWAGQAITRRNGPYLSIKAFAFR
NFLENRVWVSLILKSWSGVTTTLRHPVVINHGPRVGKCKINPASGISMVTKFAVECSDFK
DENLPLKYKIIV-SEL-DSIGAISSVEENTLGSVVYSGAEPITPAFFLPVGTVTDEYNVR
LYVQVYD-SLGTFSQVTLQATVTAPTVRDSSKDVLQQLLNVTMEPTS-PLSTLLQKQDWL
QAGYLTY

ENSGT00700000104221_2_Linker_0_1 (788, 1329)

VVISVLNNIKGEQELQDDRARLLEHLVKQSLTFAMNTADEIGQSVMVITKLTQ
KASDLSQADLEATSFRLRQASQDLQAYQHRHKHLHSRQVEVVGTGILTSLSNLLKLI---
--NP-YYTLQDPLFVVESLSDTILANKVPGSKTTALRTSNFNMYVEKVENWNVF-KAFRN
DSLCP-NCLRATLNASTVPRLPAKAPISMMFCEFADDPFPWLTYPE--NISVDVVGFRMT
GVADNNKVIEITPDIAEVYLVRKDLTPSSFNLTVGPGIK---SDGFSKVTTGGISFEVDS
RWTGELLIHIVTNVTVLFEALVYEGRQLTPTNLMATFLVPHDIPPIVKW--SGLFDPTCS
V--KEARVVCLSSSLLRSIAQRR-FSFKYNISMVLQASRFVLKPTNKLVRIAVFMVHCLD
MYGIQSDWQQSTCVLGEKTTWKTVHCICR-NGRQSRWQLTSVKLT--YHHLHTHFVTAKV
IVVPNPVDLRLAIISNLTQNPATFLAVLFIMILYAILAFWALHRDVIDLYFRDNVVILTD
NDPFDTLC

PF01477 // ENSGT00700000104221_2_Domain_1 (1329, 1436)

YLVTIFTGSRWGSGTRANVFIQLMGTESTSDVHCLSHPYFKTLYRGSINTFL
LTTKNDLGDIHSIR-VWHDNSGEAPSWYLSRIKVENLFNKRIWLFVC-RRWLSVD

ENSGT00700000104221_2_Linker_1_2 (1436, 1927)

T---T
LDATFSVTNPDEPLKRTDFFMIDVRDKLRKNHMWISIFTEIVPKPFNRLQRLSCCLAMLL
SSLVCNIMFFNLNQKEKI-ESRHMHIIRSMLIGIESVVITIPVQLLITFFFTYSQKN-LK
MNLDKVAPQKHPLMS-EEGLSWKERLHKWHEYEMKALPRRAAVSTSAPEEKEAF------
----------------------------------------ETSQ---------KHEKADT
QMSNKN--SSNNNLEASEGVPP---KAFSS--------Q-PHTTESVQK-KTQIILPRWC
VYIAWFLVFATSGISSFFIVFYGLTYGYAKSIEWLFASFCSFCQSVFLVQPCNILLRSGT
R---SYKPKYCKN--LSWSSKYHY--SEIRLQGL---TMTQEEMEQ--LHEDIA--YVRS
LSMYQPITEDKIQILRRENRIRRRSFLFLSYLVTHFIFLTLLLLLIFSLRHNDSFYYNQF
IRHRFS

PF08016 // ENSGT00700000104221_2_Domain_2 (1927, 2365)

VD-LATVMKLGDIYTWLHGV--FLPLLHNDPNPTFLLDSSSKILGLPLVRQVRA
RPSNKTCLLAKKFVQSSVAGEIHCHPRYGIDPEDTQHYSSVWSKVGKQSTDKA---SHGF
TYKPPGKRWVYHSYGVLNTYGSGGYAFYFFPGQQMFNSTVRLKELEGKNWLDELTWAVIV
ELTTLNPDTSLMCSISVVFEVSPLGVVNSSLSVYSFSLADFNRKTS---SEIYLYAAILI
FFCAYVVDEGYIIRQERASYIRSVYNLLNFSLKCMFALLIVLFFWKYLLATKMVQLYLAD
PEAFIPFHAVSRVDHFMRIILAFLLFLTILKTLRYSRFFYNVRLAQKAIQAALPGICHTA
LVVSIYSFMYVAFGYLVFGQHEWNYSSMIHATQTIFSYCVSAFQNTEFSGNKVLGVLFLS
SFMLVMICIFINLFQAVILSAYDEMKQPVYEEPSDEAEAVTYLCNRLKSGFDFLTTRSRD
KDQSNFFVDMLYGQPEKNTRRFLGLKARNINGKKMIYLVV

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------ASRFIQRSVLPFRPDGYAGFVEKANCAT
SSLEPVILEASLDKYGSKVLRTPVACVQS---PCFIKQVEI-IRTELTDRGLF-V--DHN
-FSA

PF02010 // ENSGT00700000104221_2_Domain_0 (305, 786)

NAEINCSVPYNSSHKWAIFGTAFKGGIEQKYRKLIHADWIKAAK-HSYFVVPMNGL
KPDSYSMNYTLTI--T--TSEKVITASASIKFKTEKPSLIAVI-EGGPARSVPFNKSWTL
DGSRSLDPGF---LGYPS--GLTYRWYCTTNYTYFIIGNLPASSRDSCLP-ELPDLHWFN
AKDPVVTVLPGTLQGNRTYYFILVVSLFSNRAYAYQNVTVEPGPLPKMKFSCIENCEKTL
VVPDRLSLSGKCSDCGAR-PMKYLWSIMDSTKTEIPFDWTHWSTTGRTSTYLTIKAFAFK
DFQDKMCSVILHASGWGGNFLVANHSFYVNSPPRNGYCDIHPNKGVALFTKFVVRCSGFI
DENFPLHFKVIA-SNF-WGVDNSSTVVDNTLGTVMYFGIESVTPPSFLPIGMPVNHYMVR
VYAQVYD-FLGAFSQVTLHATVTSPLGRTSPNNMLNYLLRLTQNTTGTMMTTLFQKGDFV
QAGYL

ENSGT00700000104221_2_Linker_0_1 (786, 1328)

AYLGVSLLNDVKPPPNLQAQYSEIQHHLLNVCRHLPTTTLEEINQVTVMIMGLTQ
KGSGLTAEGQKVATSRLIEVNLALQRLKEKEKEFHSEQIEIVSTGILSCLSNILKSK---
---INADMINETLHVIELLASTVLAVKFPGEMETVVTSPHLRISVWKDEKRNVN-KAFLA
QKGCQ-NCFYPTLRKNDSEYLARGGPISTAFYEFKQELST--REDT--GLSTDVVGFQMS
EIKENGNIQEVIPDLVEVFLLRKNLSGATFNITMGPDKD------LPETTSGVFTFLVF-
GTDEEVLIQIITEVKVMFKAFIYEGSNVTHSLPIASFLVPPDMPTVANE--SRLFDPTCK
VKFKVPRLICLSQSLLEAIVQDY-FASNWSISVVLQTPPIVMVPSDQLVNISIFLAECLK
MEGNEKEWDKEDCKVGDKSSWWRIHCICEIKS-KPRNESKPGDPW--ESLSRIKYLSARM
IEIPNSIDLRMEILKTIPKNPVAVFTVVLIIFTYLVLAFWAIHKDETDRIRREHVILLPD
NDPYDHI

PF01477 // ENSGT00700000104221_2_Domain_1 (1328, 1434)

CYLVTFYTGSRLGAGTKADVFVQLLGTDASSDVHCLSHPNFTTFYRGSTDSFL
LTTRSDLGNLRAIR-VWHNNEGSDPSWYLSRVKVENIFNRNIWLFLC-RSWLS

ENSGT00700000104221_2_Linker_1_2 (1434, 1927)

INK---S
LEQTFPVADKGQPMNKKDYFQIFASDNLGTSHLWLSVFASVVTGPFNRLQRLSCCLTLLM
NTLLCNIMFFNVEKEVEV-SPMELKFLRTIMRGIESALICEPMQILLASLFTYSHRKVKP
VAVTQVAP-HVHPFMKSPFQNWKERLEMWYSLETAHKQAPGRSLLRKKQAQ--GSNVTIP
EAVANAITETEEKPP--------------NSEAFLEK-NMTNTKPVD-------------
---------------EDQGTEP---------ASEESPQKSPKKVLLFEA-KPRFFFHWWC
IYVAWLLVIGSSGVSSFFIIMYGLTYGYEKSMGWLISSMTSLTESIFIIQVAKILLVSGI
R---SGRATYCKN--IPWASRYNY--LEIRLQEL---ELNADDSRE--LHYEII--RIRG
TRMYQPLVQDEIRIFRRRKKIRDRALIFLKNIISHLIFLTLLFCIISLARPSHSFHHNQA
MQNQFS

PF08016 // ENSGT00700000104221_2_Domain_2 (1927, 2365)

SK-LTTITKLDDIYRWLTGV--WLPLIHNDENPTFISNSWSKILGSPKMRQVRA
KSIKRECFLSGTMVDKLMKKGIHCHSQYSQVMEDQKNYGRLWSTRSKFSVDPR---PVSF
TYEPNLRKWSYYSYGLSHAYGSGGYPFYFFPTQKQYNSTIRLQELQESRWLDEKTWAVIL
ELTTFNSDTSLFCTISIVFEASPFGVINPSLAIHSFSLPLIYRESY---FELYLYGGALM
FIVLFLIDEATIIYWEKENYVKNVFNFLSLGLKLMFLMLILLLFVKFRLTKDILGFYLQN
PDGFTPFHVISLVDQGLSIILGFLGFLTILKTLTYSRFFYDIRLAQTTILAALPGIFHMA
LLVGVYIFMYVTFGHLVFGQHEWHYSNLIHSTQTIFSYCVSAFRDTAFLNKEVLGGLFLA
SFMLVMICILINLFQAVFLSTYKEMKQLVYEEPAAEGEAITFLFHKVRNLWRTLTCRKPF
REQPTYFSDILYGHPGNQSHQRLGLKSRNINGKRVTYVAV

MRPGPTLLL------------LGLGLCCFPAPSIPRGVPAWPSGVSR-------------
--GTAET-----------------------------------------------------
--------------------------------------------------GLHIRPAHPG
QRPRVA------------------------------------RAA-----RRPAPSGCPP
GGPMAPLD-----------------CRVA-VGPCRRHRR------------------Q--
---------------------------QLQ-APAWP--------------ATL

PF02010 // ENSGT00700000104221_2_Domain_0 (354, 788)

QVPGASL
APGLKARNSKVAVSTR-DPKALPVRDSDSTSTGAARSPPRAPL-LGAAPLTVNFTEELIL
NGTGAWGPDA---EHPAA--GQRVSWYCTADAANSGGDRAAGTDQQVCHP-DQTGPHWPW
ASGRALRLPPETLEGGRVYHFRMVTQKGHKALFSDHSVYVLRGPAPTAHIACIENCARML
AVSRRFFLFLNCTNCGR-R-DVYSWSISSVSGEPLPFNWSQQTITGRDSAYLAVRAFAFQ
SFAEAEFWVSVSLRSWGGVTSEFRRSFVVNHGPHVGQCRVSPAKGIAMFTEFVVKCNRFK
DKHAPVSYKITV-FDL-DRVGDINSGQENTLGTIVYWGTQTTTPPFFLPAGSAAHQYTLK
LSARVYD-SLGAFTQATVSVTVWPPTAISSAESVWRQILGVTTGPAS-LLSTLLQQQDWL
PASYLMS

ENSGT00700000104221_2_Linker_0_1 (788, 1329)

VVASVMNSMSTERTLSDDRAQLREHLINQSFGLPLRTSEEVGQVVVAIAKLTQ
EASEVTQVAQKRAMVRLQQANQALQTYQWEDEHRSAKQIETVGAGIVTGLSNILKLA---
--AP-QEVLEDLLFVVESLSDTIVAHKVPGSDATVLRTPSFSMHVEKAVKWDLA-QAFGK
DKHGR-NWFHATLNASRVPRLAANAPVSVMVCEFTHDPFPWLSYPE--SISTEVDGFRMT
GATDNGGVVEIMPDTVEMYLTRKNLTSVTFGLTLGPDPK---DVGSSKMTTGGFSFEVDS
GGVREVLVHIVTNETVLLTVLVYVGHHVTPNYLAANFLVPHDTPPVVTQ--SDLFDPACA
V--KVARVVCLPQSLLQVMARHS-HSPKYNVSVVLRAPSSALEPTDRLVQISIFSARCLD
MYRTQSEWREDACMLGEKTTWDKVHCTCR-DIGRTRRQPRML--P--RVPLHMHYVTAQV
VSIPNPVGLPGAVTADCQHNPVTLLTVLFIMLVYTGLASWALCRNKVDRVLRDCVIVLPD
NNSNDSVC

PF01477 // ENSGT00700000104221_2_Domain_1 (1329, 1445)

YVVTVFTGSRCQAGTRANVFVQLRGTHSTSDVHCLSHPHFRTLFRGSVSAFL
MTAKRDLGDIHSIQ-VWHDNGGQAPCWYLSRIKVENVFSGHIWLFMC-RKWLSIDT---T
LDRT

ENSGT00700000104221_2_Linker_1_2 (1445, 1927)

FHVLRPEEPVGRKDFFLIDLPHKLRTHHAWFSVFAGFVPKPFSRLQRLSCCLAVLL
SSLFCNSVLFNLNRHEQA-ASREGRYTRSMVIGTESVLITLPVQMLITFFFTHSQRI-PQ
GGRDE------QALVLEGSGCWEEGLCKWYTHRGTRGASKPTL-----------------
----------------------------------------------KHQHEKADSDA---
-------NVHNRNTGDTHDVPS---GEPP---------S-HQGPKRCQT-QCWIALPWWC
VYTAWFFVLATSTVSSFFIIFYGLTYSSDESVEWLFASICSFCQSVFLVQPLKIILESGI
R---TNKPTYCKD--LAWATEHPS--CEIKLCGL---RMPRDEARK--LREHVA--QLRA
SRRYQPLTEDEVRIFRRFRRVRRRAILFLSYLMTHYIFMALLLLLIVRLRHTDSFYYNQF
ILGRFS

PF08016 // ENSGT00700000104221_2_Domain_2 (1927, 2365)

RD-LAAVTKPEDIYRWLSLA--LLPLFHNSQNPTFLPDSSSKILGLPRMRQVRA
KPTEKTCPPAKSFMQYNLAGEIHCHPAYGTDPQDTGNYSRFWSEVDKQARGMN---TEGF
TYKPQGKTWVYYSYGLLNTYGSGGYVFYFFPEQQQLNSTLRLLRLQQSNWLDEKTWAVIL
ELTTFNADSSLFCSISIIFEVSQLGVINASISTQSFSLAEFHRESS---AEIYLYAAILI
FFVAYIVDEGYVIMQERISYVKSIYNLLNFALKCIFTMLVTLFFRKYFLATGMIQFYLSN
PHDFVPFHLVAQVDHTMRITLAFLLFLTILKTLRYSRFFYDVRLAQRVIQAALPGICHMA
VVVSVYFFVYMAFGYLVFGQHEWNYSNLIHATQTIFSYCVSAFQNTEFSNNRVLGVLFLS
SFLLVMVCLLINLFQAMILSAYEDMKQPVYEELSEEVEVMSYLYHKLRKVFSFLAPNDQT
RDEPEFFIDMLYGKPEKNSCRYLGLKTRNINGKKVVYLVV

MGPGPALL-LL---------GLGLGLGCGPGRPPPPPAPAQAPASRDPGE-----RGAGF
GGLGAGRARVSLRARAAPGGGIFLSGRR----------GLCLPAGRPPSLVPRCV-----
RAHVQLR--ARRAPA------AAAPA-----PVDLQLSAPGGRLSLRWLSRLPRS-----
LGPL-EWTFRLGLLGPAAAESRAL-------------PRRALQRGRRSYPGFVARTECPT
DRPT-PVVLEAVSPNSSEPTESSVSYQVFRPWPCKLDPVRI-NRNDD-RPVRL-TRDMED
TFNA

PF02010 // ENSGT00700000104221_2_Domain_0 (305, 788)

TVILFCPIQEYYYRGWYIYSVPYVGA-VPDWTKPLEKPPVKFSRGFFEVTIPPYSL
PWGVYLFNFSVVVRTR-DPQVPGKNDSDRIYVVIFRRPLNAVI-SGPSNITINFTDGVTL
NGNMSSDPEE---TDPLEKERLKFLWYCTTNSRNYDGENITVISKEVCLP-EQVDLKWTW
ASGPILTLSPETLQGGRVYFFRLVIQKTSRSAFADATVHVLQGE-PVASTSCIENCDQVL
VLSERFSLSLDCTGCTAGR-DVYRWSILTSSGQEVPLDWTGQTSTGRNGAYVSIKAFAFW
NFREDKFWISLNAATWSGVTLVLRYPFVIHHVRITTDCKIVPEKGISFITQFVVICTHFK
HKNIVLTYKIIV-PDV-HGFGEISSLKENNFGSILYLGKNSTSPPSFLPVGVLDSHYALK
IIAQAYNTSLGAFSQVNLYATVRPPTDVKSSPTVLEELSNFTMGPNS-SLSTLLQQQDFL
NASYLIY

ENSGT00700000104221_2_Linker_0_1 (788, 1327)

VVASVLNSMKSDLSLQADKIKIREHLFNQTLILPINTLVNISQVVMAVTKLTE
KTSEISAFSQKLATVRSWQASQALQDSHQRDKSISSEQIESVCIGILITLSNILKLL---
--VH-YEVFEEPFHVLESLADTVLAVKVPENETTALRTSNFKMYVKKTEKWNVT-KFFST
QKHCQ-NCFYPSLNVNSVPSLPASAPISTMFCEFADDPFPWLNYGE--NILTQVVGFRMT
GVEATGDVIEIPPDAVEVHLIRKNLSFGSFNLTVGPSSEPYAVDESATKTTGAFSFVVDG
TAGRDVLIHIMTDVSVLFTVSVYAGREITPNSFMTSYLVPHKIPPIANE--SDLFDPECA
V--KEARVVCLPAALVQVIAQRT-DSSECTIAVVLQAPRFVLKPNNKLVRISVFSSECLD
MFGIQSDWREDTCAVGEKTTWQRVHCICK-NPRRAKRQLDIIKQA--NLRLRTHYLTAKV
IVVPNPVDLRVETVKNVTQNPVTLFTVLLIMLLYLILAFWALHRDETDQYLREHVIVLLD
NDPYDN

PF01477 // ENSGT00700000104221_2_Domain_1 (1327, 1433)

VCYLVTVFTGSRCGSGTRANVFIQLHGTKGSSDVHCLSHPQFTTLYRGSICTFL
LATKKDLGDIHSLR-VWHNNEGRSPEWYLSRIKVENLFSRHIWLFMC-RKWL

ENSGT00700000104221_2_Linker_1_2 (1433, 1927)

SIGS---S
LDRTFQVMPPDKPLKKMDFFLIDLSYKLGRSHLWFSVFSGVISTPFNRLQRLSCCLAMLL
STLLCNIMFFSLEKEIEA-EPQEQRYIRSMVIGLESAFITLPVQLVIKSLFMYSQRR-PQ
VTLHEVTPRKHPLKA-PARQHWEERLGNWHAYEIDKASSQEPVSNRHHAKPKGS--VNVT
SKRQPPAKN-------------------------------------QSNVTQAQSKFSNI
QGRN--INTNNPNIEDNTNVSD-----EQP--------P-QPGSTALKE-KTRMVLPQWC
VCVAWLLVFLTCAVSSFFIIFYGLTYGLEKSTAWLFASFCAFTQSVFLVQPSKIMLVSGY
R---TRKAKYCKN--VSWIGNSRF--SEIKLHNI---RKDPEEMDR--RHRYVM--ELRN
SRMYQPLTQDEITIFQRKKRIKRRAFLFLSYILTHFIFLALLLSLVTILHPTDSFYYNQF
TRDQFS

PF08016 // ENSGT00700000104221_2_Domain_2 (1927, 2365)

VD-LAGVTRLEDIYQWLNRV--LLPLFHNDPNPTFFPDSSSKILGLPLMRQVRA
QPGDIMCLPAKKFVEGSLKGEIRCHPEYGIDPEDTKNYSGSWNRVSKRDTDKT---TRGF
TYRPPEKRWAYSSYGLLHTYGSGGYAFYFFPAEQQFNSTLRLSELQKSHWLDEKTWSVIV
ELTTFNPDISLLCSISVIFEVSQLGVVNTSLNAHSFLLADFNRKNSADSAENYLYLAIFI
FFLAYTVDEVYVITQERTAYVQSVYNLLNFALKCIFTLWIVLFFRKHFLAISIVQAYRSN
PEDFIPFHAVAQVDHTMRVILGFLVFLTILKTLRYSRVFYDVRLAQRAIQIALPGICHMA
LVVSVYFFVFMAFGYLVFGQHEWNYSDMIHATQTIFSYCVSAFENTEFFNNRVLGVLFLS
SFMLVMICILINLFQAVILSAYEEMKQPVYEEPSEEAEAMTYLCRRLRSAFCCLCFKPRA
EDEPKFFINMVYGQPEKNSRHYLGLKTRNINGKKMVYLVV

MSPAAALVLLL---------LLSRGEGGLPQPPAPRGPPADRPD-----ALDGLGTGRPL
RGRGAQAPLSLQRAPRPPRDGAVLSGQA----------RLPFPTAGAXX----XXXXXXX
XXXXXXX--XXXXXXX---------X-----XXXXXXXXXXXXXXXXXXXGCRGPLRRP-
PGLP-AWTFLLRLLGLEARGAC------------ASP-RSVLP-GPRPSADFVAQNPCPT
DGPV-PVVLEAANASGHRALESSVSCQVA---RCRLYGVRI-NRNADADHVRL-TRNEEV

PF02010 // ENSGT00700000104221_2_Domain_0 (301, 713)

TLNTTTDMDCSA---MYQRWYLYSVPAVGD-EPDWMQPLRVAGLGDSRTPTIVHIPKASL
GWGVYLFNFTVVINTW-DPAARVLTESDRIYVWIVRSPLVAVL-AGEANITASYTDELIL
NGSMSSDPDA---NDTLQ--GLLFSWYCTTNPKNYNGDQIQVVSKEVCHP-AQANLRWPK
ARDPVLALSPGLLKGGQAYFFRMVIHKGNRRAYSDKTVHVLPGPTPPAHILCLENCGSHL
IVSDRFSLYLNCTDCVS-S-DLYNWSIVSELDVEMPVDWTGQTFTGRNTAYLSLKAFALS
HFVEAKFWVSVRVTSWGGKTLEFKHPIVMNHGPQSGECKIKPAXXXXXXXXXXXXXXXXX
XXXXXXXXXXXX-XXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX

ENSGT00700000104221_2_Linker_0_1 (713, 1327)

XXXXXXXX
XXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXLQKY-QRDKHFRCEQIEIVSTGILTSLSNILNQS---
---A-HEVFEDPFYLAESLSDTLLACKVPANEA-MMQSATLKVYLEKTEKENVT-QVFKN
TQFCQ-HCFQATLNGSRVPGLPIKTVVSTAFCEFAEDPFPWLHYPE--TTSAEVFGFRMW
GATENADAREITPNVLEVFLNRKNLTFATFNLTVGPDEK---ADGSLRKTTGGFSFEVDH
REVTEVLVHIVTEVTVWFKVLVYAGSQVTPTSLLATFLVPHDVPPIANQ--TDQFDLDCA
V--KQARVICLPTSLLQIMAQHS-QSPKCAIIMMLEAPRFVQKPNNMLVKISLFSVHCLG
MYAIQSDWREDYCRLGERTTWEKVHCVCK-DVGRAKRQLSIKNLP--NIQLHTHFLTAKV
IVVPNPVDLRIKNIKSLGQNPVTLFTVLFIMLLYIILAFWALHRDEMDQFLRDNIIILPD
NDPYDK

PF01477 // ENSGT00700000104221_2_Domain_1 (1327, 1445)

ICYLVTVFTGSRWGSGTRANVFVQLTGTEGVSTVHCLSHPYFTTLYRGSINTFL
LTTKSDLGDLHSIR-VWHNNEGTSPSWYLSRIKVENLFSRQIWLFMC-RTWLSVDT---V
LDRT

ENSGT00700000104221_2_Linker_1_2 (1445, 2099)

FQVIPPDMPLRKRDFFLIDVSKNLAKNHLWFSIFAGVVARPFNRLQRLSCCLALLL
STLLCNIMFFNANKEQED-GSRDMQYRSXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XX
XXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXX---XXXXXXXX------
--XXXXXXXXXXX---------------------------XXXXX-XXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXX---XXXX---------X-XXXXXXXXX-XXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXX
X---XXXXXXXXX--XXXXXXXXX--XXXXXXXX---XXXXXXXXX--XXXXXX--XXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX---X-XXXXXXXXXXXXXXXXXXX
XXXXXXXX-XXXXXXXXXXXXXXXXX---XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX---XXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXX

PF08016 // ENSGT00700000104221_2_Domain_2 (2099, 2365)

XX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX---XXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXNLALKCFFTALLVLFLRKHVLASGVTELYLLN
PKDFIPFHAVSQVDHTMRITLAFLLFLTILKTLRYSRIFYDVRLAQRAIQTALPGICHMA
LVVSVYFFVYMAFGYLVFGQHEWNYSDLIHATQTIFSYCVSAFQNTEFSHNRVLGVLFLS
SFLLVMICILINLFQAVILSAYEEMKQPVYEEPSEEVEAMTYLCHRLRPMFGFMSPQPRA
EEEPEFFNDMLYGQPEKKSHRYLGLKTRNINGKKRVYLVV

MRPGPTLLLL----------GLGLGLGCFPSASTSRGAPAWPSGAPGGTPGLRLRFR---
------------------------------------------------------------
-------------------------------------------------------PARPG
LRPRVAPEDNVLPRDRGESGC-------------RAAPPRPAQSAPRPNA-----SGSPP
GRPA---------------TRSD---GRAAVGLCRFQQVKI-VRGRAQGPALR-RRKAEA
PLGNSV------------------------------LPRRAPQLQAWAR

PF02010 // ENSGT00700000104221_2_Domain_0 (350, 786)

LPTLHVPGASL
PPNLSVFNVTVALSTP-GAKALPGRDSDSISTGPVRSPRRAPL--RDAGLTVNFSDELIL
NGAMSSDPDA---DAPVE--GLRFSWYCTTNAGNFAGDQVTGTDQEVCHP-DQVSLHWPW
ASGRVLRLSPETLRGDRVYYFRMVTQKGHKAVFSDKRVHVLRGPTPIALLSCIENCDRML
AVSRRFFLFLNCTSCGR-R-DVYSWSIFSASGKEVAFDWTRQTITGRNSAYLSVKAFAFQ
SFLEAQFWVSVYLRGWSGVTLEFRHSFIINRGPQVGACQVHPGEGIAMFTKFVVKCSHFE
DKHHPLTYKITA-SDL-GSAGDMALVKENTLGTILYWGTRATTPPSFLPVGSSAHHYALK
ISAQVYD-SLGAFSRVTLSVPVWPPTDISSARTVWQQLLNVTTGPMS-LLSTSLAGQHWL
LASCL

ENSGT00700000104221_2_Linker_0_1 (786, 1329)

MNVVASVLGSMKTEQTLSDGKAHLREHLINQSFALPLRTLEEVGQVVMAIATLTQ
EPSEVTQVAQKRATVRLWQANQALQMYHREDKHFSSEQIEMVSAGILMSLSNLLKRA---
--TP-HEAVEDPSYVVESLSDTILAHKVPGSEATVLRAPGLNMYVEKVAKWDVA-QAFRK
DKHGQ-NWFHAILNASRVPSLAANAPVSVVVCEFTHEPFPWLSYPE--SISTEVDGFRMT
GATDNGTVVEIMPDTVEVYLTRKNLTRATFNLTVGPDRE---VAGSSKMTTGGFSLEVDS
RGVREVLVHIVTEVTVLLTVLVYVGRHVTPTHLVATFLVPHDMPPLVTQ--SGLFDPACA
V--RVARVVCLPLSLLQVMAWHS-QSPKYNISVVLQAPSFVLEPTDKLVRISVFSARCLD
MYRSQSEWREDACMLGEKTTWDKVHCTCR-DGGRPGRQLRNP--T--RVPLPMHYVMAKV
TSVPNPVDLRWTVTPARQHNPVTLLAVLFIMLIYTVLASWALRRNEIDQLVRDCVVVLPD
NDPYDSVC

PF01477 // ENSGT00700000104221_2_Domain_1 (1329, 1445)

YLVTVFTGSRCGAGTTANVFVQLRGTEGTSDVHWLSHPHFGTLFRGSISTFL
LTTKRDLGDIRSIR-VWHSNEGKAPSWYLSRIKVENLFSGRIWLFMC-RKWLSIDT---T
LNRT

ENSGT00700000104221_2_Linker_1_2 (1445, 1927)

FHVLGPDDPVKRKDFFLIDLTYKLRTHHVWFSVFTGFVAKPFSRLQRLSCCLATLL
SSLFCNSVFFNLHRHEQV-ASRDGRYVRAMMIAVESVLITIPVQVLITFFFSHSQKK-PQ
VDLDEVVPQKQPLTL-EDSGCWEERLCKWYACEAAKGGTSEDSEPTFK------------
--VSPGRPKASVQ--------------------------------------VATEAAHQP
EKAETNTNVHNRNAEDTQDVPS---GVPS---------S-QQDPERRQT-QPWLTLPQWS
VYIAWFFVLTTCTVSSFFILFYGLTYSYDKSVEWLFASFCSFCESVFLVQPLKIILESGI
R---TNKPKYCKD--LAWSTKHQY--MEIRLQGM---RMSPDEVQK--LQEHIA--HLRG
SRMYQPLTEDEVRIFRRRKRIRRRAVLFVSYIVTHCIFLALLFLFIILLRHTDSFYYNKF
ILDRFS

PF08016 // ENSGT00700000104221_2_Domain_2 (1927, 2254)

TD-LAAVTKLEDIYKWLNLV--LLPLFHNDQNPTFLPDSSSKILGLPRMRQVRA
KPTGKTCPLAKRFMQNSMAGEIHCHPKYGADPEDTRNYSRFWSEVNKQAMDRN---TDGF
TYKPQGKTWVYYSYGLLETYGSGGYVFYFFPEQQQLNSTLRLRELQESSWLDEKTWAVIV
ELTTFNPDVSLFCSISVIFEVSQLGVVNASISTHAFSLAELHSESW---AEIYLYVAILI
FFLAYVVDEGYVITQERASYMKSVYNLLNFALKCIFTVLVTLFFRKYFLAAGMIQFYLSS
PHDFIPFHAVSQVDHTMRIILAFLLFLTILKTLRP-------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------

VRGGRALLSL-RP-------TRGLRC----------------RGS----S----RGA---
------------IAASAAAGGVVLSGRG----------SLGFPVGGPGG-----------
-AGTASC--C-APAQRPTPARPAAPT-----LVDLQLRRAAVA-SPCVVRALTALARRF-
-----GLAFALRLSA-RGRRPASP-ATR--------VFPRSAAPGPRPQPGFVARTECPT
DGPA-RLMLQAVNSSRHRAVESSVSCQIN---TCVIQRVRI-NTDQRGAPVRL-SMKAEA
TLN

PF02010 // ENSGT00700000104221_2_Domain_0 (304, 786)

ASVQLDCPAALAISQYWQVFSVPAVGD-APDWTQPLDVPQLEIRKSPMFIHIPSNSL
QWGVYVFNFTVSITTR-NPKMPEVKDSDAVYVWIVRSSLQAVM-LGDVNITANFTEQLIL
DGSTSSDPDA---DSPLQ--GLQFFWYCTTDPRNYPGDRIILGSKEVCHP-EQANLKWPW
ATGPVLTLLPETLKGDHVYFFRMVIQKDSRTAFSDKRVHVLQGPKAIAHITCIENCDRTF
IVSDRFSLFLNCTNCAS-R-DFYTWSILSSSGGEMLFDWMGETVTGRNGAYLSIKAFAFQ
HFLEAEFSISLHLASWSGVTSVFRHSFIINHGPQIGECKINPAKGIALITKFVVQCSNFR
DKHVPLTYKIIV-SDL-HSVGEISSVKENTLGTILYLGPQSTSPPSFLPVGMVANQYALK
IYVQVYD-SLGAFSQVTLHATAQAPTDKNSSKTVLNQLLSFTMGPSS-LLSTLIQKQGFL
PAGYL

ENSGT00700000104221_2_Linker_0_1 (786, 1329)

LYIVASVLNNMRTELPLQNDRVNLRKHLINQSFLLPVSTLVEIGQVVMTITKLTQ
KPSEFTWDAQKRATMRIWQANQALQEYQQKDKRFQSEQIEIVSTGILMSLSNILKMT---
--SP-HQVVKDPFYVIESLSDTILANKVPGNKTTSMRTPNFNMYVKKVEKWGVT-QVFRN
EKHCR-NCFYPTLNVSSVPGLSANAPISTMFCDFTNDPFPWLNDQE--NTSVQVFGFRMT
GVADNGSVLEITPDVAEVYLVRKNLTFAAFNLTVGPNGD---VDGSSKKTTGGFSFQVDS
RVLREVLVHIVTEVMVLFTVLVYTGSQITPTALVATFLVPHDIPPVASQ--SALFDPACT
V--KKARVVCLPVSLLQLIAQHS-HSPHCTVSIVLQAPHFVMKPNDKLVRISIFSIQCLD
MYGIQSEWREGYCVLGEKTSWHDVHCICK-NIVRARRQLGTVGLT--NIHLHTHYVMAKV
IVIPNPVDLRLNIIKSLHRNPVTLFTVLSIILLYVILAFWALYRDEIDEHLRGRVIVLPD
NDPYDNLC

PF01477 // ENSGT00700000104221_2_Domain_1 (1329, 1445)

YLVTIFTGSRWGSGTRANVFVQLRGTVSTSDVHCLSHPHFTTLYRGSINTFL
LTTKSDLGDIHSIR-VWHNNEGHSPSWYLSRIKVENLFSRHIWLFIC-QKWLSIDT---T
LDRT

ENSGT00700000104221_2_Linker_1_2 (1445, 1927)

FHVTHPDEPLTRKDFFFIDVSSNLQKNHMWFSIFASVVAKTFNRLQRLSCCLAMLL
SSLLCNIMFFNLNRQEQT-ESRERRYMRSMMIGIESVLITIPVQLLITFLFTYSQRK-PQ
ADLKEVSPQKHPLMS-EASEHWEECLTKWHAYETAKAHPREVA------KPASK------
--GKPRLPKASPK---------------------------ATSKP-KHRHRKARIKTPET
PRPNTNS---NNNIEDNQDVHS---E-EHP--------S-QQDLQQLKK-KPRIVLPWWC
VYVAWFLVFATSSISSFFIVFYGLTYGYDKSMEWLFASFCSFCQSVFLVQPSKIILLSGF
R---TNKLKYCKN--LSWSTKYKY--TEIRLDGM---RMHPEEMQR--IHDQIV--RIRG
TRMYQPLTEDEIRIFKRKKRIKRRALLFLSYILTHFIFLALLLILIVLLRHTDSFYYNQF
IRDRFS

PF08016 // ENSGT00700000104221_2_Domain_2 (1927, 2365)

MD-LANVTKLEDIYRWLNSV--LLPLLHNDLNPTFLPESSSKILGLPLMRQVRA
KSSEKMCLPAEKFVQNSIRREIHCHPKYGIDPEDTKNYSGFWNEVDKQAIDDS---TNGF
TYKPQGKQWLYYSYGLLHTYGSGGYALYFFPKQQQFNSTQRLKELQESNWLDEKTWAVVL
ELTTFNPDVNLFCSISVIFEVSQLGVVNTSISLHSFSLADFDRKTS---AEIYLYVAILI
FFLAYVVDEGYIIMQERASYVRSVYNLLNFALKCIFTVLIVLFLRKHFLATGIIQFYLSN
PEDFIPFHAVSQVDHIMRIILGFLLFLTILKTLRYSRFFYDVRLAQRAIQAALPGICHMA
FVVSVYFFVYMAFGYLVFGQHEWNYSNLVHSTQTVFSYCVSAFQNTEFSNNRILGVLFLS
SFMLVMICVLINLFQAVILSAYEEMKQPVYEEPSDEVEAMTYLCRKLRTMFSFLTSQSKA
KDEPEFFTDMLYGQPEKNSRRYLGLKTRNINGKKMVYLVV

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--

PF02010 // ENSGT00700000104221_2_Domain_0 (363, 860)

GVYIFNFSVCIKLG--ENMPPVEGSQIFYVIVERKPLEAVL-LGSKDITVEFTDNVVL
DGSGSNDPEV---GNSLQ--GLKFTWYCTTNQKNYQGKNITVISKDVCIP-EQKSLRWTS
DPGSKLEISPKFLQGGQVYFFRMVVEKIGRSAFADKVVRVRRGPIPMA-IYCIENCGTVL
TTSDRFSLFVNCSNCIVGR-DIYEWFIMSPNGQEITFDWSGETTTGKNSDYFTVKAFAFS
HFLEDTYYTAVRITSWSGMFDIVIYSFMINEAPRVRECYINPATGTALDTKFVVKCGDIQ
DNNIPLKYKAIV-SDS-HSLANISSLKENTMGGISYFGTELTSTSFFLPVGDMTKIYYLK
MYFQVYD-SFGAFSQVTLYTIVQAPTDHVATETVLQQLHNLTTGPNS-TLSDLLQKQDKL
DAGYLIYLAASVLNNIQMNSTIRNDMVQLREHLVNQTFQLPLDTLEEITQVVAAFAKLTQ
TASDVTELSQERSTERISQ

ENSGT00700000104221_2_Linker_0_1 (860, 1327)

ANQALQEYRKRNKQFHSEQIDTVCTGIFRSLSNLLKLS---
--AH-HKVFEEPIYVLDSLADTVLASVVPENETKVLQSPGINMYVKKAEMWNLL----GY
EAYNG-NDFHAVVHIGSVPGLPVNAPISMTLTEFAEDPFPWLSYPA--HTSTEVVGFRAS
GESVNGDEVEITPEVVEVFLARKNLSSEVFNITVWPSNDSDRD-NNSKTTTGAFRFEVDC
SEQKEVLLHIITEVKLLFRVFLYVGDSFTHNALIATYLVPRDIPPMANQ--SDLFDPNCT
V--KAARVVCLSPSLLQVIAERL-QSTDCVIAVVLQATRFVLSPNGKLVRISVFRAQCLD
MYGIQSEWNEHSCTLGEKTSWQRVHCVCKTKDIQQPQ--ATPTPA--NLRRHSRYLSAKV
TSALNPVDLLLE-VKNIAGNPVTLYAILFIMITYIGLAFWALHRDETDQFLRQHVIILPD
NDPYDK

PF01477 // ENSGT00700000104221_2_Domain_1 (1327, 1445)

TCYLVTVFTGSRCGSGTRANVFVQLLGTESTSDVHCLSHTHFPSLYRGSINTFL
ITTKNDLGDIHSIH-VWHNNEGSSPSWYLSRIKVENLFSRKIWLFMC-RQWLSIDT---S
LYRT

ENSGT00700000104221_2_Linker_1_2 (1445, 1992)

FYASQPDQPVSRLDFFLIDVTYKMCKSQMWFSVFAAVIEKPFNRLQRLSCCLAVLL
SSLLCNIMLLNFYPSEEK-EPPQGQYIRLMMIGMGSVLITLPVQLIITALFIYSQRK-PL
AALEDVAPXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX---------
-----------------------------------------XXXX-XXXXXXXXXX----
---XXXXXXXXXX------XXX---XXXXX--------X-XXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXX

PF08016 // ENSGT00700000104221_2_Domain_2 (1992, 2365)

XXXXXXXXXXXXXXXXYGSDPEDTRNYSASWDTVANQAPEET---DSGF
TYKPTQRSWAYRSYGLSHTYASGGYTFQFFPEEQQFNSTLRIKDLQSSHWLDEKTWAVIL
ELTTFNADSSLFCSLSVIFEVSQVGVVNTSLSAHSFSLADFNRDTS---SEIYLYVAILL
FLLAYIIGEVYVISQEGALYVRSVISLVNFVFKSLFLVLAVLFIRKHALAMWVIQFYLSN
PVAFLPFHAVSQVDQFMRMILGFLLFLAFLKTLKYSRVFYNVRLAQRAIRAALPGICHMA
FVVSVYIFLYMAFGYLVFGQHEWNYSHLMHSTLTIFSYCVSAFHNTEFCNNRALGILLLS
SFILLMICILINLFQAVILSSYEEMKQPVYEEPSEEAEAMAYLYHKLRTMSSSVGFHSET
REEPMFFVHVVYGHL-KNNYWYMDLKTKNIIGSRV-YLVT

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------

PF01477 // ENSGT00700000104221_2_Domain_1 (1327, 1443)

ESFLVTLYTGSRWGAGTKADVFLQLIGQNGTSDVHCLRHPQVPSFRRGSTDRFL
LTSREDLGDICAFR-VWHSNRGPSPGWFLSRAKVENTSTRKTWLFMC-RKWLSLDKGDGL
LER---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-GSHCDRLSVHLYLSPQGFLWDQVPPELEVHFFNIGPLGTHGLLHLVWFVPLQHPLLHL-
-----QWTFHLQLPGAGTT--------RPAPPASRFIPRSVLPTL--MSTQFMEKADCST
NNLEPAILEASLDTYGSKVLKSPVACVQN---PCFIHKVRI-KIG------LSGM--DGF

PF02010 // ENSGT00700000104221_2_Domain_0 (301, 860)

TINTAVQVNCSIPHNVTRDWNFYPVM---Q-TPDWSRPLRTWWIRKMKHFSFFHIPEGVL
KQGLYLVNFSVTV--T--AAEKEMKASDAMFLSISKSQLQSLR-EG--ARRVAFNEIWTL
DGSSSSDPDS---HDPSE--GLDYRWYCTTNWIHFDCD-RASLHKDACLP-WMSDLRWIH
KSVPVYTIFPRTLRGNQVYYFRLVVQKDERKSFKDQRVTVTAGPPPVTSFSCIENCENNL
ILTDRFSLSGKCTDCGSA-PVYYLWSLLSASGKEIPFDWVHQTTTGRTNPYVSIKASAFK
GFREV-LLISLKVSNWGGGFSVSNHSFYINSPPHVGQCKIHPDKGIALVTKFVVQCSNFR
DYNLPLSFKIIA-SSF-WDVDDISSLDQNTLGAVMYFGPQPVTPPSFLPVGMPVNNYLVK
IYAQVYD-SLGAFSQVTLDAIVNSPLVKDSPNTMLGLLFNLTQNSSGAMLTTLFQQRDFI
QAGYLVFLVASVLNNVKPLPDLPLD----QERLINFCNHLPTNTLVEISQVTVAIVELTQ
EGSGLTAGVQKAATSRLME

ENSGT00700000104221_2_Linker_0_1 (860, 1327)

MNLALQSYRQREKTFHSEQIEIVSTGISTSLSNIFKTG---
---SQKDTVNETLYVTELLADTVSSIKVPGEVETVISTPNLKMHINKDEKHNVT-GAFLA
KKDCQ-NCFYPTLRKSKVTDLESEGPVSTVFYEFKDDPFPWLSQGE--RPSVDVVGFRMR
ETKENGDTFEVEPETVEAFILRKNLKEVAFNLTVGPDKD------FLKMTTGVFNFVVN-
-GLQEVFIHIITEVKVLFRVLIYVGSNITHTLPIVSFLAPPDMPPVANE--SALFDPTCK
V--KVPYLICLSQSLLQAIARGS-DSTNWHISVVLQSAYIVMKPNHKLVRISIFTAQCLK
MDSIQQEWGWKDCAVGNGSSWWRVHCICHLKP-EPTNASKPREP---GSRSRIKYLTARM
VVIPNSLDLRVDIIQTLPQNPVSLFTVIFIVFTYLVLAFWAMHKDETDRFLREHVIILPD
NDPYDH

PF01477 // ENSGT00700000104221_2_Domain_1 (1327, 1450)

VCYLVTFYTGSRLGSGTRADVFLQLLGTEASSDVHCLSHPDFTTFYRGSTDTFL
LTTRSDLGSIRAIR-VWHNNEGSHPSWYLSRVKVENIFNRHIWLFLC-RSWLSV-E---S
LEQTFQAAD

ENSGT00700000104221_2_Linker_1_2 (1450, 1926)

KAQPLSRKDYFLIHASDLLGTSHLWLSVFASVVTGPFNRLQRLSCCLTTLL
CTLLCNIMFFNKDEEEEV-MPVELKHLRGIMRGIESALICEPMQMVLGALFNYSQRKVSE
VPATHVAP-RLHPLM----SEWKERLEMWYRHETVLPHLRETSPQKSR--P----RGTTA
------------------------------------------------------------
-SEAA-----------------------------ANATQRQRGTQLGAP-KPGLVLHWWC
VYVAWLLVIGTTGVSSFFIIVYGLTYGYQKSTQWLFASVSSLCQSIFVVQVAKILLLSGI
K---SSRAKYCKN--IPWTTRYNY--IEIRLHGL---NLNADDTRE--LHYEIV--RVRG
TRMYQPLVEDEIRIFRRRTRIKKRAIVFLRNIVNHFIFLGLLLCIVSLLRHSHSFHHNQA
VRSQF

PF08016 // ENSGT00700000104221_2_Domain_2 (1926, 2365)

STN-LEKVRELNDTYRWLTDV--LLPLVHNRQHPTFLSNSWSRILGLPRMRQVRA
KSIKKSCFLSGTAANRLMKKGIHCQHQYSG-PEDRKNYGRFWTSLTESSVDSR---PVSF
TYES--SKWAYYSYGLVHAYGVGGYPFYFFPDQEQYNSTIRLQELQKSRWLDERTWAVIL
ELATFNSDTSLFCTVSVVFEVSPLGVINPSLEVHSFSLPLFRRRA------AYLYGAAMV
FLVVYLVEEVITIHQEKENYIRNRFNLVSFGLKSMFLFLILLLYIQFRMAKEILDFYLKN
LDDFTPFHAISHLDQVLRIALGFLVFLTILKTLMYFRFFYDVRLAQRAILAALPGIFHMA
LLVGVYIFVYVIFGYLVFGQHQWHYSSIIHSTQTIFSYCVSAFEDTAFLNKQFLGGLFLA
SFMLVMICVLINLFQAVILSAYEEMKQLVYEEPAEEVEAATYLFHKVRNLFRFLTCRAPA
QEEPAYFTDILYGHPENKNYQYLGLKTRNINGRRMTYVVV

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

PF02010 // ENSGT00700000104221_2_Domain_0 (685, 860)

SVVENTLGTIY-FGT-KTTPPSFLPVGELANHYAMK
VHAQVYD-SLGAFSQVTLRTAVQPPTVSNSSKTVLAQLLGLTKGPTS-LLSTLLQKQHFL
PAGYLMYMVASILNTMKTDSTLQDDKSHLQEHLVNQSFVLPLSTLEGMSQVVTTITKLTQ
SASGFTGVARKHATARIWQANQALQEYRRQDQRFRSEQIEIVSTGILTSLSNFLKLA---
--TR-HELVKDPFHIAESLSETVLASKVPGNETTILSTPNLKMYVQKVEKQDVA-QVFRD
EKRCP-NCFHPALNASSAPALPANAHVSTMFCEFAGDPFPWLNFQE--NISTQVVGFRMT
GARDKDNTVEVTPDVAEVYLIRKNLTFEAFNLTVGWDTE---GDESLKKTRGAFSFDVDT
STGREVLVHIVTKVTLLFQVSVYAGSQVAPSALVASFLVPNNIPPVANQ--SGLFNLACP
V--KQARVVCLPAALLQGIAQRS-HSARCTISMVLQAPRFVLKPNSKLVRIHLFSVQCLD
MRGIQSEWRGDSCALGEKTSSHTVHCVCK-NVVRARRQLGPVRFS--NLHLHTRYVAAKM
IVIPNPVDLQIKLIQKLNQNPVSVFFVL--LLIYIVLAFWALHRXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--
XXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXX---X
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XX
XXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXX----X-XXXXX------
--XXXXXXXXXXX---------------------------XXXXX-XXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXX---XXXX---------X-XXXXXXXXX-XXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
X---XXXXXXXXX--XXXXXXXXX--XXXXXXXX---XXXXXXXXX--XXXXXX--XXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXX-XXXXXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX---XXXX
XXXXXXXXXXXXXXXXXXTYG-SGYAFYFFPEQQQFNSTLRLKELQGSNWLDEKTWAVIL
ELTTFNPDVNLICSISVIFEASQLGVVNTSISVYSFTLADFNRQTS---AEIYLY

PF00520 // ENSGT00700000104221_2_Domain_2 (2156, 2358)

VAILI
FFLAYIVDEVYIITQERASYVRSVYNLLNFALKCIFTVLIMLFFRKHFLATGIFHFYLSN
PDDFVPFHAVSQIDHIMRIILGFLLFLTILKTLRYSRVFYDVRLAQRAIQTALPGICHMA
LVVSVYFFVYVAFGYLVFGQHEWNYSNFLHATQTILSYCVSAFQDTEFSSNRFLGVLFLS
SFMLVMICILINLFQAVILSSYDEMKQPVYEEPSEEAEAMAYLYRKLRDVFSFLTSQPQA
KEEPVFITNMLYGQPAKKSHRYLGLKTRNINGKKMVYLV-

MRPGPAL-LLL---------GLGLGLGLLPPHPAPRGARAAVPG-----SGGLLRGARGL
RERGGRTRLSLRRRA-ARDGGVLLSGSR----------DLCFPRGGPGR----RRVSPRP
PGWYCLG--VRVLLRGR--PGPAAPT-----HVDLRVSAPRGRLSLAWSARLP----HS-
LGPL-AWAFRLRLLGPGEARPTRA-RRAAAAT-RPSA-LSVLPADPRPYSGFVAHTQCPT
DGPT-PVVLEAVDSSNRTAMTSSVSCQIR---SCIIKQVKI-NTNNDSAPVFL-TRKEEA
TIN

PF02010 // ENSGT00700000104221_2_Domain_0 (304, 787)

ATAQYDCPFAQAIATYWQVFSVPSVND-VPDWTQPMDLSQIEIKNDPLFIHIPRSSL
HWGVYVFNFTVSITTS-DPRMPLVQDSDSIYVCIVRRPLKAVI-LGNASMTVNFTDELIL
NGAMSSDPEA---DDPLE--GLQFFWHCTTNPHNYREDQIMVMNQEVCHP-EQTNLKWPW
ASGPVLTLLPETLKGAQVYFFRMVIQKGFRRAFSDKRVHVLQGPRAIAHISCIENCDRTL
IISDRFSLFLNCTNCAR-R-DFYKWSILSSLGSEVLFDWMGQTVTGRNSAYLSIKAFAFS
HFSEAEFSASLYVASWSGDISVFRHFFIPNHGPQLGECKINPAKGIALFTKFVVQCSNFK
DQHIPLTYKIIV-SDL-HGIGEISSVKENSLGAILYLGTEPTAPPSFLPVGVLTNHYATK
IYAQVYD-SLGAFAQVTLYATVQAPTDKNSSKTVLHQLLDLTNGPSS-LLSTLLQKQNFL
SAGYLM

ENSGT00700000104221_2_Linker_0_1 (787, 1329)

YIVASVLNNMKAELPLRAEKVNLREHLVNQSFLLPASTLVEIGQVVTTITKLTQ
KPLELTGVAQKRATVRIWQANQALQEYQQKDKHFSSEQIEIVSTGILTSLSNILKLT---
--VP-HEVVEDPFYVIESLSDTILANKVPGTETTVMRTPNFNMYVKKVEKWKVT-QVFRN
ETRCR-NCFYPALNVSSVPALPANAPVSTMFCEFAEDPFPWLDGGE--SASVEVVGFRMT
GAADNGTVIEITPDVVEVYLVRKNLTFAAFNLTVGPSSE---LDGALKKTTGVFSFEVDS
RVLREVLVHIVTEVTVLFEVLVYAGSQLSPTALVATFLVPHDIPPVASQ--SALFDPACT
V--KAARLVCLPLSLLQVIAQRS-HSSQCAISVVLRAPRFVIKPNDRLVRISLFSVQCLD
MYGIQSEWREDNCVLGEKTTWHKVHCVCR-HAVRARRQLGTLRLT--SLHLHTCYVMARV
IVVPNPVDLQLKVIKNVYHNPVTLFTVLFIMFLYMVLAFWALHRDEMDQFLREHVIVLPD
NDPYDNIC

PF01477 // ENSGT00700000104221_2_Domain_1 (1329, 1445)

YLVTVFTGSRCGAGTRADVFVQLRGTASTSDVHCLSHPHFTTLYRGSISTFL
LTTKSDLGDIHSIR-VWHNNEGKAPSWYLSRIKVENLFSRHVWLFIC-RKWLSVDT---T
LDRT

ENSGT00700000104221_2_Linker_1_2 (1445, 1927)

FHVTHPDQPLNRRDFFFIDVSNKLGKNHMWFSIFASVVPKPFSRLQRLSCCLAMLL
SSLLCNIMFFNLNRKEQT-QSREGRYIRSMMIGIESVLITIPVQLLITFLFTYSQKK-PQ
VKLEEVSPQEHPLMS-EDGGHWEERLGKWHARQTAVTHASETA---KTVKPASR------
--RKPGIPKPSVK---------------------------ATFRS-KHQHEKAETKAPET
HRPNTNSNNNNNNREDNEDVPS---EEPS---------S-QQDLAPPKK-KPRIVLPWWC
VYAAWFLVFAASSISSFFIVFYGLTYGYERSVEWLFACFCSFCQSVFLVQPSKIILWSGI
R---TNKPKYCKN--LSWSTRYHY--SEIRLRRM---NMHPEEMRR--LHDRIS--QIRG
TRMYQPLTEDEVRIFKRKKRIKRRALLFLSYLATHLIFLALLLVLIGLLRHTDSFYYNQF
LRDQFS

PF08016 // ENSGT00700000104221_2_Domain_2 (1927, 2365)

MD-LAAVTKLEDVYRWLNSV--LLPLLHNDLNPTFLLDGSSTILGLPLMRQVRA
KSTEKPCLPAENFVQNSIKREIRCHPKYGIDPEDTKDYSSFWNEIDKRHTHKN---TNGF
AYKHQGKQWVYYSYGSLHTYGSGGYAFYFFPKQQKFNSTLRLRELQESNWLDEKTWAVIL
ELTTFNPDVSLFCSISVVFEVSQLGVVNTSIALYSFSLAEFNRKAS---AEIYLYVAILI
FFLAYTVDEGYIIMQERASYVRSVYNLLNFALKCIFTVLIVLFLRKHFLATGMIRFYLSN
PEDFIPFHAVSRVDHTMRIILGFLLFLTILKTLRYSRFFYDVRLAQKAIQAALPGICHMA
FVVSVYFFVYMAFGYLVFGQHEWNYSNLIHATQTIFSYCVSAFQNTEFSHNRILGVLFLS
SFMLVMICILINLFQAVILSAYEEMKQPVYEEPSDEVEAMTYLCGKLRTIFGFQTSQSRA
KDEPEFFVDMLYGQPEKNNHRYLGLKTRNINGKKMVYLVV

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------Q

PF02010 // ENSGT00700000104221_2_Domain_0 (394, 777)

IERADLLANI-TGGSVRTVGFSESWTL
DGSDSSDPDS---QEG----QLIFTWYCTKDSADYKT--MKFSLKNRCHP-FQKDLRWIT
PSGPIQKIPPESLPGSTLYYFRLLIQKARRKAYADQIVEVDPGPPLILSMRCLENCGRSI
IPTERFSLSGKCSNCKPSNKPLYYWSLFSDASKEINFDWDSKTSTGRSGAYMSIHARTFI
KPEYPSYILHLSVTTWDGRSTSSTTPFEVNIPPQGGRCNISPRYGIAFLTKFVVRCSRFY
DSHTPLTYKVIVASDI-PQTTPITSVAENTFGPILYFGYEPITPPSFLPAGEASQ--TLT
LYVQVRD-SMGAFTQMSLRVLIKNPLKTQSLSAVFHDLLASASHLSM-S-ASNQQTEDRI
RAGYLAYLAASLLNYVKNTPTVQLPQTQLRGSVVNTVLSISVRSIMEINQVAAVLSEVTD
AVEKMNVRSQDLAIGKLTELTRALLR--QRHRTRLSEEAEIQTSGILRCLSNILSADLLL
LKNVSATGMQHIFSIMEGIVEVVSLGKVPEDTETLIETDHWNITLKKKEAWNIT-KYLPA
TYTCH-NCF---------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------MRPGPALFDPRSQPGFVARTECPT
DGPA-RLMLQAVNSSRHRAVESSVSCQIN---ACVIQRVRI-NTDQRGAPVRL-SMKAEA
TIN

PF02010 // ENSGT00700000104221_2_Domain_0 (304, 786)

ASVQLDCPAALAISQYWQVFSVPAVGH-APDWTQPLDLPQLEIRKSPLFIHIPSNSL
QWGVYVFNFTVSITTR-NPKMPEVKDSDAVYVWIVRSSLQAVM-LGDVNITANFAEQLIL
DGSTSSDPDA---DSPLQ--GLQFFWYCTSDPRNYRGDRIILGSKEVCHP-EQANLKWPW
ATGPVLTLLPETLKGDHVYFFRMVIQKDSRTAFSDKRVHVLQGPKAIAHITCIENCERTF
IVSDRFSLFLNCTNCAS-R-DFYTWSILSFSGGEMLFDWMGETVTGRNGAYLSIKAFAFQ
HFLEAEFSISLHLASWSGATSVFRHSFIINHGPQIGECKINPAKGIALITKFVVQCSNFR
DKHVPLTYKIIV-SDL-HSAGEISSVKENTLGTILYLGPQSTSPPSFLPVGMVANQYALK
IYVQVYD-SLGAFSQVTLHATAQAPTDKNSSKTVLNQLLSFTMGPSS-LLSTLIQKQDFL
PAGHL

ENSGT00700000104221_2_Linker_0_1 (786, 1329)

LYIVASILNNMKTELPLQNDRVNLRKHLINQSFLLPVSTLVEIGQVVMTITKLTQ
KPSEFTWDAQKRATMRIWQANQALQEYQQKDKRFRSEQIEIVSTGTLISLSNILKMT---
--SP-HQVVKDPFYVIESLSDTILTNKVPGNKTTSMRTPNFNMYVKKVEKWGVT-QVFGN
EKHCR-NCFYPTLNASSVPGLSANAPISTMFCDFTNDPFPWLNDQE--NTLVQVFGFRMT
GAADNGSVLEITPDVAEVYLIRKNLTFAAFNLTVGPNGD---VDGSSKKTTGGFSFQVDS
RVLREVLVHIVTEVMVLFTVLVYTGSQITPTALVATFLVPHDIPPVASQ--SALFDPACT
V--KKARIVCLPVSLLQLIAQHS-HSPHCTVSIVLQAPRFVMKPNDKLVRISIFSIQCLD
MYGIQSEWREGYCVLGEKTSWHDVHCICK-NIVRARRQLGTVGLT--NIHLHTHYVMAKV
IVIPNPVDLRLNIIKSLHQNPVTLFTVLSIILLYVILAFWALYRDEIDQHLRGHVIVLPD
NDPYDNLC

PF01477 // ENSGT00700000104221_2_Domain_1 (1329, 1445)

YLVTIFTGSRWGSGTRANVFVQLRGTVSTSDVHCLSHPHFTTLYRGSINTFL
LTTKSDLGDIHSIR-VWHNNEGHSPSWYLSRIKVENLFSRHIWLFIC-QKWLSIDT---T
LDRT

ENSGT00700000104221_2_Linker_1_2 (1445, 1927)

FHVTHPDEPLTRKDFFFIDVSSNLQKNHMWFSIFASVVAKTFNRLQRLSCCLAMLL
SSLLCNIMFFNLNRQEQT-ESRDRRYMRSMMIGIESVLITIPVQLLITFLFTYSQRK-PQ
ADLEEVSPQNHPLMS-EASEHWEECLRKWHAYETAEAHPREVA------KPASK------
--GKPRLPKPAPK---------------------------ATSRP-KHRHRKAQIKTPET
PRPNTNS---SNNTEDNQDVHS---K-EHP--------S-QQDLQQLKK-KPWIILPWWC
VYVAWFLVFATSSISSFFIVFYGLTYGYDKSIEWLFASFCSFCQSVFLVQPSKIILLSGF
R---TNKPKYCKN--LSWSTKYKY--TEIRLDGM---RMHPEEMQR--IHDQIV--RIRG
TRMYQPLTEDEIRIFKRKKRIKRRALLFLSYILTHFIFLALLLILIVLLRHIDSFYYNQF
IRDRFS

PF08016 // ENSGT00700000104221_2_Domain_2 (1927, 2365)

MD-LANVTKLEDIYRWLNSV--LLPLLHNDLNPTFLPESSSKILGLPLMRQVRA
KSSEKMCLPAEKFVQNSIRREIHCHPKYGIDPEDTKNYSGFWNEADKQAIDES---TNGF
TYKPQGKQWLYYSYGLLHTYGSGGYALYFFPKQQQFNSTLRLKELQESNWLDEKTWAVVL
ELTTFNPDVNLFCSISVIFEVSQLGVVNTSISLHSFSLADFDRKTS---AEIYLYVAILI
FFLAYVVDEGYIIMQERASYVRSVYNLLNFALKCVFTVLIVLFLRKHFLATGIIQFYLSN
PEDFIPFHAVSQVDHFMRIILGFLLFLTILKTLRYSRFFYDVRLAQRAIQAALPGICHMA
FVVSVYFFVYMAFGYLVFGQHEWNYSNLIHSTQTVFSYCVSAFQNTEFSNNRILGVLFLS
SFMLVMICVLINLFQAVILSAYEEMKQPVYEEPSDEVEAMTYLCRTLRTMFSFWTSRSKA
KDEPEFFIDMLYGQPEKNSHRYLGLKTRNINGKKMVYLVV

MRTGPALLLLL---------GLHLGLGLLPPPPPAPHRGARRPP-----ASACG-AA---
-RPGTAASSSAAAATSAS------SAAG----------PAGRAAGGAC-----PRGPRAG
TAWACAS--C----SAA--AGPRAPA-----HVDLRVSAARGRLSLAWSARLPRSAGRW-
PGPS-AAVARAR-GGPAAR----------------ARRAAARPAADRPSSGLVARTPCPT
DGPT-PVVLEAPGSPNRTATASNVSCQLG---ACTIKKVKI-NTNNDSTTVFL-SRKEEV
TLN

PF02010 // ENSGT00700000104221_2_Domain_0 (304, 786)

ATADYNCLFAYSISESWHVFAVPSVND-EPDWTQPMDLSRLDRGRSVLFIGIPPYSL
PVGVYMFNFTLTIKTR-NPRMPVVEESDAIYVCIVTRPLKAVI-LGNPNVTVDFNEELIL
NGTMSSDPEA---DDPLE--GLRFSWHCTTNPQNYHEDQILVMSKEVCHP-EQTNLNWPW
ATGPVLTLLPETLKGAQVYFFRMMIQKDTRTAFSDKRVHVLQGPKASALISCIENCDQIL
IVSDRFSLFFNCTNCAR-R-DFYKWSILSSLGSEVLFDWVGQTVTGRNSAYLSIKTFAFS
HFLEAEFSASLHVASWGGDISVFSHLFVTNHGPQIGECKINPTKGIALFTKFVVQCSNFK
DKHIPLTYKIIV-SDL-HNIGEISSVKENTLGAILYLGTKSTAPPSFLPVGMLANHYATK
IYAQVYD-SLGAFTQVTLYATVHAPTDKNSSTIVLDQLFELTMGPFS-LLTTLIRDEEFL
SANYL

ENSGT00700000104221_2_Linker_0_1 (786, 1329)

TYIAASILNSMKPELSLQDSKDYLREHLVSQSFLPPTSTLAEISQLVTTLSILTQ
KPFELTQEAQKRATERMWQASQALQEYQQTDKRFSSEQIEIVSTGILTGLSNILKRI---
--DS-QKMVEDPFYVIESLSDTILASKVPGTETTVMRTPNFNMYVKKVEKWKVT-QVFRD
EKHCR-NCFYPTLNVSSVPALPADAPISTMFCEFAEDPFPWLNDGE--STSAEVVGFRMT
GATDNGTVIEITPDVVEVYLVRKNVTFAAFNLTVGPSRE---LDGALKKTTGAFSFEVDI
RAFREVLVHIATEVTLLFEVLVYAGSQLTPTALVATFLVPHDIPPVVSH--SALFDPACA
V--KAARVVCLPLSLLQVIAQRS-HSSQCTISVVLQAPSFVIRPNDRLVRISLFSVQCLD
KYGSKSDWREDNCVLGEKTTWHKVHCVCG-HAVRARRQVGTVRLS--SLPLHTRYVMARV
IVVPNHVDLKLKVIKNVYQNPVSLLTVLFIIFLYTALAFWALHRDEMDKILRENVIILPD
NDPYDDTC

PF01477 // ENSGT00700000104221_2_Domain_1 (1329, 1445)

YLVTVFTGSRCGAGTRADVFVQLRGTASTSDVHCLSHPHFTTLYRASISTFL
LTTKSDLGDIHSIR-VWHNNEGRAPSWYLSRIKVENLFSRHIWLFIC-RKWLSVDT---T
LDRT

ENSGT00700000104221_2_Linker_1_2 (1445, 1927)

FHVTHPDEPLTKKDFFFIDVNHKLGKNHTWFSIFASVVPKPFTRLQRLSCCLAMLL
SSLVCNIMFFNLNRAEET-ESRERRYLRSMMIGIESVLITIPVQLIITFLFTYSQRK-PQ
VNLEEVSPQKHPLIA-EDGSHWEERLGNWHARQTAKT-----A---KTAKPASR------
--RKPGLPKPSVK---------------------------ATFRS-KRQSEKAETKAQET
QRPNANSNNNNNNREDDEAVYS---EESS---------S-QEDLPQPKK-KSRIVLPRWC
VYLAWFLVFATSSISSFFIVFYGLTYGYEKSIEWLFACFCSFCQSVFLVQPSKIILLSGI
R---TNKTKYCKN--LSWSTKYHY--SEISLQRM---NMQPEEMRR--LHDHIS--HIRG
TRMYQPLMEDEVRIFKRKKRIKRRALLFLSYLVTHLIFLALLLVAIGLLRHTDCFYYNQF
LRDQLS

PF08016 // ENSGT00700000104221_2_Domain_2 (1927, 2365)

VD-LGGVTKLEDIYRWLSSV--LLPLLHNDLNPTFFPDDSSTILGLPLMRQVRA
TSSERPCLPADNFVQNSIKGEIRCHPKYGIDPEDTKDYSSSWNKIDQQH-PRN---TNGF
AYKQQGKQWVYYSYGSLYTYGSGGYAFYFFPKQQKFHSTMRLKELQESNWLDEKTWAVIL
ELTTFNPDVNLFCSISVIFEVSQLGVVNTSISVYSFSLAEFNRKTS---AEIYLYVAILI
FFLAYIVDEGYVITQERASYMRSVYNLLNFALKCMFTVLIVLFLRKHFLAAGMIQFYSSN
PDDFIPFHAVSRVDHTMRIILGFLLFLTILKTLRYTRFFYDVRLAQRAIQAALPGICHMA
FVVSVYFFVYMAFGYLVFGQHEWNYSNLIHATQTIFSYCVSAFQNTEFSHNRILGVLFLS
SFMLVMICILINLFQAVILSAYEEMKQPVYEEPSDEVEAMAYLCGKLRTVFGFQTSQSRA
KGEPEFLVDMLYGQPEKNNRRYLGLKTRNINGKKMVYLVV

MRPALLLLL----------LGLGLRCGGLPPPTATRGAPAGVPAAAL----RSFAGARGL
HPLRGHARLGL-RPRVALGGGVLSGSGR----------GLCSSRG-----------PAWR
PRWHCLH--VRVLLRALRAR-RAAPT-----RVDPHLLARGGQRSLRRLAPLRGLL----
-RPR-ERTLHLGLVSPTDAS--------------------SASRGLHPDAGFEAQTKCPT
DVNS----------GSWPAGESAESCRLLRQGTCSIKKLQI-NRKPGL-PAVLLTRRMDI

PF02010 // ENSGT00700000104221_2_Domain_0 (301, 860)

SLKATLQYDCPVAHTTQPNWKVFSVPSLRH-QPDWTKPLVVPGFQLGNDPTVMHIPKKTL
SLGVYVFNFTVILVPS-LPQAAVVKGSDSVYVSILSDFLQAVL-LGDVNMTIKFTDQLVL
DGSTSVDPDV---DDPLE--GVQFSWFCTTNSKNYNGDKINVISKEVCLP-KQVDLQLTW
ASDPVLTMSPETLRGGHVYFFRMVIQKAPRSAYSDKRVRVLQARAPKASISCIENCGRIL
VLSDRFSLSLNCPDCARSR-EVYKWSILRTSGGEVAFDWLGQTSTGRDSDSLSIKAFAFR
NFSEAQFWIVLDLATWGGVNLSLMRSFTVNYAPAIGDCKINPTSGIAFFTKFVVQCNNFK
DQNIPLTYKMIV-SDLYDGFGEISSLTENTLGPILYVGNDPRCPPSFLPVGGGDSHYSLK
VFVQVYD-ALKAFSQVTFYVTVQAPTGQASPQAILTQLVNFTAGQNS-EISTLLQKQEFL
FAGYLMYVVASVLNSMKPEPALQADKAWLREHLVNQSSLLPMNTLMEINQVVTVFAKLTQ
RTSEFPQVARQSATERIWQ

ENSGT00700000104221_2_Linker_0_1 (860, 1327)

ANQAFLQHQQKAKNLHSEQIETMSTGILTSVSNILKMT---
--DP-HIIFVDPFRVIQSLADTILAGKVPDDESTVISSASFTMYASKLEKGAVSNNILGN
ERHCR-NCFQPTLNVSSIPRLPANAPVSVVFCEFADDPFPWLNYQD--SLAADVVGFRLT
GISANGDELELTPDVADVYVSRRNLSSAAFNLTVGPDHEPDNADESSRMTTGAFRFEVDS
RAVRELLVHIVTEVTVQFTVLVYAGGQITPSALVATFLVPHGIPPIANQ--SGLFDLACA
V--SVPRLVCLPLSLLQVIAQRG-HSPECVIIMVLKAPHFVLQPSDKLVRISLFSVRCLD
MYGVQSDWTEDTCVLGEKTTWDRVHCVCR-KARRARRQLA-------NVPLHFRYLTAKV
IVPPNPVDLRLEVIKNVTQNPVTLFVVLFILVTYIVLAFWALHRDETDQYLRDHAIVLPD
NDPYDN

PF01477 // ENSGT00700000104221_2_Domain_1 (1327, 1445)

ICYLVTVFTGSRCGSGTRANVFVQLMGTQGTSDVHCLSHPHFKTLYRGSVHTFL
LTTRRDLGDIQSIR-VWHNNEGHAPGWYLSRIKVENLFSRHIWLFMC-REWLSIET---S
LDRT

ENSGT00700000104221_2_Linker_1_2 (1445, 1926)

FPVTDPNTPLQRMDFLLIDATDNLGKNHLWFSVFAGVISRGFNRLQRLSCCLAMLL
STLLCNIMFFNLDTEKQDKQDQGNRYVRSMIIGLESVMITLPVQVIITGLFTYSQRR-PQ
ATLDQVTPQEYPEVA-EESGHWEERLERWHAQETATEARSQEARAQEARSQKSR------
------SQKT--------------------------RSQRRTSKA-GHSLRKKDSKGPHP
PDANANANKEN--MNSSPQVPS---AQPPPPPQDQEPRD-PFAPPPPPT-KPRTTLPGWS
KWIAWFLVFATSGVSSFFIVFYGLTYGYEKSIEWLFASLSSFCESVFLVQPSKIILLTGM
R---TNRLKYCKN--LSWVSNYRY--TEIQLQDL---RLRPEEMHQ--RHQDLT--RLRG
SSMYQPLTQDEVGIFRRKRALKRRALLFLGHFLTHCIFLALLLGLVALLRRTDSFRYNQF
IRSRF

PF08016 // ENSGT00700000104221_2_Domain_2 (1926, 2365)

SVD-LATVTKLDDIYPWLHSA--LLPLFHNDLHPTFLPDSSSKILGLPLLRQVRA
TPGPKACRPAKRFPPNSIEGEIRCHPEYGADPEDTSDHPGFWKKVAKREADKN---TNGF
TYKPPEERWVYYSYGLLHTYGSGGYVFYFFPDQQQFNSTLRLRDLQSGRWLDEKTWAVIL
ELTTLNADAGLLGSTSVLFEVSQLGVVNASISVHSFSLVDLNRDTS---AEVYLYVAILV
FFVAYVVYEGYVITQNGASYLANPNNLFNLALKCTLAVLIVLFLRKYFLATGIIQFYSSN
PVDFIPFHAVAQVDRTLGIVLGLLLFLTILKTLRYFRFFYHVRLAERVLQTALPGICHVA
LLVFVYFFLFVAFGHLVFGQHEWGYSTLIRATQTVFSYCTAALRNAEFSSNRALGVLLLA
AFVLLLICVLIHLFAAVILSAYKALRQPVYEEPSGEAEAIAYLCGKLRTVFGFLCCQPKA
QEQRELFVDMLYGKPERRSSHYLGLKTRNINEKKMVYLVV

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------PNAIESSVSCQMK---PCLINQVKV-NRNETPSPVRL-TLKTEA

PF02010 // ENSGT00700000104221_2_Domain_0 (301, 860)

TINATVEVDCPYARSITQYWEIFSVPSALH-VPDWTKPLEVPQLQTRVNSSFLHIPKSSL
TWGVYVVNFIVSITTS-DPAMPLVKDSDYIYVEVVRSHLKAII-PGDYRITMNFTDGLVL
NGTMSSDPDA---DNPSE--GLKFFWYCTTNPGNYQGDEITVSSSQICHP-GQTDLRWTW
ASGPVLTLVPETLKGNRVYFFRMVIQKSDRTAFSDKRVHVLQGLTPKASISCIENCGRIL
IISDRFSLFLNCTNCAISR-IFYKWSVLSPIAREMPFDWTGQTATGRNGAYLSMKAFAFQ
QFLEARYWISLYIATWGGVILVFRHGFVINHAPQIGECKLNPVTGIAFVTKFDLGCSNFK
DKDIPLTYKIIV-SNL-HSICEISSLKENTLGAIPYLGTQSRAPPFFLPVGVLANHYAVK
LYVQVYD-SQGAFSQVTLYATVRAPTDENSPRTVLHQLVNATMGPSS-SLSTLLQKQDFL
SAGYLLYIVASVLNSMKTDLTLLNVKTNIRKHLVNQSFLLPMTTLVEISQVVTIITELAQ
KESEFTQVDQKLATVRIWQANQALQAYRQKETHFRSEQIETVSTGIFTILSNILKQI---
--AS-HQIVQDPFYVVESLADTILASKVPGGETTVLRTSNLNMYVKKIEKWDVT-KVFAQ
EQHCR-NCFYPILNESSGPDLPPNAPISTMFCEFADDPFPWLNYGG--NISTEVVGFRMT
GAKANGDVLEVIPDVVEVYLIRKNLTSTAFSLTVGPNGEHDEVDESLKKTTGGFRFEVDS
RVVKELLVHIVTNVTVLFKLLVYAGSQITPTALVATFLVPHDTPPTASQ--SGLFDPACS
V--KEARVVCLPQSLLQVIARRR-RSSKVCHIRGSAGPLVFVLTPTKLVRIFSFQRSLLD
MSGIQSDGREDI------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------PIR-VWHNNEGK-PSWYLSRIKSGKSVHQIHLACSCAGNGFLLTT---S
LDRKFRVTHSDEPLNRMDFFFINTTYELGRSHMWFSVFAGVIAKPVNRLQKLSCCLAVLL
SSLLCNIMFFNANRQE-T-VSKRLYYLRLMMIGIESALITVPVQLLLIFLFTYSQKKPTH
VNLDEVLPRKHHPVMSEESGFWDNRLAKWYAYETTKLQTRQGT-----------------
------------------------------------------IKT-QSQLEKAEAEAPQM
HRSTNSNNNNKDNKKDSQDFL-----------------S-KEPPSQQKP-KARILLPWWC
VYVAWFLVFAICSISSFFIVFYGLTYGYDLSIQWLFTSFCSFFQSIFLVQTSKIILLSGF
R---TSKPKYCKN--LPWTIKYRY--TEIKIHGL---RKNPAEKHK--QHLHIN--HIRG
TRMYQPLTEDEIRIFQRKKRIKKRALLFLSYILTHFIFLALLLVLIALLHHTDSFYYNQF
IRDYF

PF08016 // ENSGT00700000104221_2_Domain_2 (1926, 2365)

STD-LATVTKLEHIYRWINKV--LLPLFHNDLNPTFLFDSSSKILGLPLMRQVRA
KPSEKKCLPDKTLVLNIIKREIHCHPKYGIHPEDTKNYSSFWNDVDEQAISKN---PNGF
TYKPPEKKWAYYSYGLLHTYGSGGYVFYFFPEQQQFNSTLRLRELKGNNWLDEKTWAVIL
ELTTFNPDVNLFCSISVIFEVSQLGVVNSTVSVHSFSVSDFNRNTS---AEIYLYLAILI
FFLAYIVDEGYIIMQERASYLRSVYNLLNFALKCIFTVLIVLFFRKHLLTTDIIQFYLSN
SMDFIPFHAVSRVDHLMKIILAFLLFLTILKTLRYSRVFYDVRLAQRAIQIALPGICHMA
FVVSIYFFVYMAFGYLVFGQHEWNYSNLIHATQTVFSYCVSAFQNTEFSSNRVLGVLFLS
SFMLIMICILINLFQAVILSAYEEMKQPVYEEPSDEAEAMTY-CRQLRMVFSFLTFRSRA
KDEPEFVIDMLYGQPEKNNCRYLGLK-RNINGEEMVYLVV

-------VYL-AV-A------QRRGCGHV---------------A----PG---------
--------------------------R---------------------------------
-----------------------SPPRA---LGTRAFRGVGGAGAERGGARRPRSPASS-
-----LVGFGQ--TGPGPGSGPAP-EARPDYSATRRVPWEQGAPGQR---SLSSLCRCGR
QL-----PARAVNSSSHRAVESSVSCQIN---ACVIQRVRI-NTDQKGAPVRL-SMKAEA
TIN

PF02010 // ENSGT00700000104221_2_Domain_0 (304, 786)

ASVQLDCPAARAIAQYWQVFSVPAVGQ-APDWTQPLDLPQLEIRNSPLFIHIPSNSL
QWGVYVFNFTVSITTG-NPKMPEVKDSDAVYVWIVRSSLQAVV-LGDANITANFTEQLIL
DGSTSSDPDA---DSPLQ--GLQFFWYCTTDPRNYRGDRINLGSKEVCHP-EQANLKWPW
ASGPVLTLLPETLKGDHVYFFRMVIRKDSRTAFSDKRVHVLQGPKAIAHITCIENCERNF
IVSDRFSLFLNCTNCAS-R-DFYKWSILSSSGGEMLFDWMGETVTGRNGAYLSIKAFAFR
HFLEAEFSISLYLACWSGVTSVFRHSFIINHGPQIGECKINPAKGIALITKFVVQCSNFR
DKHVPLTYKIIV-SDL-HSVGEISSVKENTLGTILYLGPQSTAPPSFLPVGTLASQYGLK
IYAQVYD-SLGAFSQVTLHATAQAPTDKNSSKTVLNQLLSFTVGPSS-LLSTLIQKQDFL
PAGYL

ENSGT00700000104221_2_Linker_0_1 (786, 1329)

LYIVASVLNNMKTELPLQDDRVNLRKHLIDQSFLLPVSTLVEIGQVVMTITKLTQ
KPSEFTWDAQKRATMRVWQANQALQEYQQKDKRFRSEQIEIVSTGILMSLSNILKMT---
--SP-HQVVKDPFYVIESLSDTILANKVPGNKTTSMRTPNFNMYVKKVEKWGIN-QLFRN
EKHCR-NCFYPTLNVSSVPGLSANGPVSTMFCDFTNDPFPWLNDQE--NTSVEVSGFRMT
GVADNGSVLEITPDVAEVYLVRKNLTFAAFNLTVGPNSE---VDGSLKKTTGGFSFQVDS
TVLREVLVHIVTEVMVLFTVLVYTGSQITPTALVATFLVPHDIPPVASQ--SALFDPACT
V--KKARVVCLPVSLLQLIAQHS-HSPHCTLSVVLQAPRFVMKLNDKLVRISIFSVQCLD
MYGIQSEWREGYCILGEKTSWHEVHCICK-KAVRARRQLGTIGLT--GIHLHTHYVMAKV
IVIPNPVDLRLNIIKSLHQNPVTLFTVLFIILLYVGLAFWALYRDEMDQHLRGHVIVLPD
NDPYDNLC

PF01477 // ENSGT00700000104221_2_Domain_1 (1329, 1446)

YLVTIFTGSRWGSGTRANVFVQLRGTVSTSDVHCLSHPHFTTLYRGSINTFL
LTTKSDLGDIHSIR-VWHNNEGRSPSWYLSRIKVENLFSRHIWLFIC-QKWLSVDT---T
LDRTF

ENSGT00700000104221_2_Linker_1_2 (1446, 1927)

HVTHPDEPLTRKDFFFIDVSSNLRKNHMWFSIFASVVAKTFNRLQRLSCCLAMLL
SSLLCNIMFFNLNRQEQT-ESRERKYMRSMMIGIESVLITIPVQLLITFLFTCSQRK-PQ
ADLNEVSPQKHPLMS-EASEHWEEYLRKWHAYETAKVHPGEVA------KPASK------
--GKPRLPKASPK---------------------------ATSKP-KHRHRKAQIKTPET
LGPNTNS---NNNIEDDQDVHA---E-QHP--------S-QKDLQQLKK-KPRIVLPWWC
VYVAWFLVFATSSISSFFIVFYGLTYGYDKSIEWLFASFCSFCQSVLLVQPSKIILLSGF
R---TNKPKYCKN--LSWSTEYKY--TEIRLDGM---RMHPEEMQR--IHDQIV--RIRG
TRMYQPLTEDEIRIFKRKKRIKRRALLFLSYILTHFIFLALLLILIVLLRHTDCFYYNQF
IRDRFS

PF08016 // ENSGT00700000104221_2_Domain_2 (1927, 2362)

MD-LATVTKLEDIYRWLNSV--LLPLLHNDLNPTFLPESSSKILGLPLMRQVRA
KSSEKMCLPAEKFVQNSIRREIHCHPKYGIDPEDTKNYSGFWNEVDKQAIDES---TNGF
TYKPQGTQWLYYSYGLLHTYGSGGYALYFFPEQQRFNSTRRLKELQESNWLDEKTWAVVL
ELTTFNPDINLFCSISVIFEVSQLGVVNTSVSLHSFSLADFDRKAS---AEIYLYVAILI
FFLAYVVDEGCIIMQERASYVRSVYNLLNFALKCIFTVLIVLFLRKHFLATGIIRFYLSN
PEDFIPFHAVSQVDHIMRIILGFLLFLTILKTLRYSRFFYDVRLAQRAIQAALPGICHMA
FVVSVYFFVYIAFGYLVFGQHEWNYSNLIHSTQTVFSYCVSAFQNTEFSNNRILGVLFLS
SFMLVMICVLINLFQAVILSAHEGMKQPVYEEPSDEVEAMTYLCRKLRTMFSFLTSQSKA
KDEPEFFIDMLYGQPEKNSHRYLGLKTRNINGKKMVYLVV

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-APA-REGLKAANSSGSRSTAPSESCQLA---NCVIHRVQI-RRDKDPVPFVW---MKDS
SIN

PF02010 // ENSGT00700000104221_2_Domain_0 (304, 788)

ASVQYDCRMNVYIVYKWQIFPVRSVNH-VPDWTRPLHI---QLQANLPLLRIPKFTL
QQGVYVFNFSMTINKP-D--GKVLSATDAVYVQVSGHPLKAVL-LGGADVTVNFTDELIL
DGSKSSDPDA---DRPLE--GLVFSWYCTTNLSNYHLDEITVFSKDVCHP-EQTSLNWLQ
ASSPKLTLAPETLKGDRVYYFRMMVKKGSKSAFSDKRVRVLPGPLPTAHISCTENCGQSL
VVSDRFSLFLNCKDCVS-R-DFYNWSILSSAGDEVLFDWTRQTVTGRNSAYLLVKAFAFS
HFSEARFWVSVSLTSWKGMTMVFRYGFIINHGPQVGKCQVNPARGFAVVTQFVVQCSNFK
DKDIPLTYKVIV-SDV-ESVGEISSVEENTMGTTLYLGTGSTAPPSLLPAGVPANHYALK
FYAQVYD-SLGAFSQVTFYATVQAPTDKNPSKTVLDQLVHLTTGPTS-LLSTLLQKQDML
PAGYLIY

ENSGT00700000104221_2_Linker_0_1 (788, 1329)

VVASVLNSMKTEPTLQSDKVNLQEELVKQSFKLPVNTLDEIGQVVMIITKLTQ
KGSEFTELAQQKVLEKLWQANQALQEYQRKDKNFRSEQIDIMSTGILMSLSNILHLI---
--IQKGRVVEDPFKVVESLSDTILADKVPSNETTVLRTPKLNMYVERVEKWDVS-QAFRN
EECCQ-NCFHATLNASRVPGLPEKAPVSMMFYEFTDYPFPWINAAE--NTSAGVIGFRMT
GATEKGKVIEITPDVVDVYLVRKNLTSVNFNLTVGPSKE---HEGSLKKTTGGFEFEVDI
RRVREVLIHFVTEVTVLFKVFVYAGSQGAPADVVAVYIMPHDVPPVVDHSWSDLSDAACA
V--REARVVCLPPSVLQIIAQRS-HSPKCTISMVLQAPHFVLEPSDKLVRISLFSVNCMD
MYGIQRDWKEDTCVLGEKTTWDTVHCVCK-NAVRTRRQLGALKLA--YHRLHTHFVTARV
IVIPNPVDLRLTVIGNVSQNPVTLFTVLFIILLYTVLAFWALHRDEMDHFLRDHVIILPD
NDPYDTMC

PF01477 // ENSGT00700000104221_2_Domain_1 (1329, 1436)

YLITVFTGSRCGAGTRANVFVQLNGTKSKSDVHCLSHPHFKALYRGSINTFL
LTTKSDLGDIHSIR-VWHNNEGRAPSWYLSRIKVENLFNRQIWLFIC-RKWLSVD

ENSGT00700000104221_2_Linker_1_2 (1436, 1927)

T---T
LEETFPVTLPDEPLKRKDYFLIDVTRRLGKNHLWFSVFTNIVSKSFNRLQRLSCCLAMLL
SSLVCNIMFFNLNVKE---QSKEGRYIRSMMIGIESVIITIPVHLLITFFFTYSQKR-PQ
VSLDEVAPQKHPLLS-EESGYWKERLDKWHGYTTEKASTKRTA---RA------------
---------------------------------------------------SEESSSSDI
HRT--NTNASNRNREDDQDVPS----------------Q-QESPQHLNK-KPQFILPSWC
VYVAWFLVFATCSMSSFFIIFYGLTYGYEKSVEWLFASVCSFCQSVFLVQPCKIILLSAA
K---TSKPKYCKN--LSWSTKHGY--IEIRLREL---IVSPKEMQT--FHQHIL--NLQG
SRMYQPLTEDEIRIFRRKKRIRRRAILFLSYLLTHFIFLALLLLLIALLRHTDSFYYNQF
IRDQFS

PF08016 // ENSGT00700000104221_2_Domain_2 (1927, 2365)

VD-LAAVTKLQDIYRWLDGV--LLPLFHNDLNPTFLIDSSSKILGLPLLRQVRA
KAGERVCLPSENFVENSISKEIHCRPKYGTDPEDTKNYSSFWNAVSKRETDNA---ANGF
TYKPREKKWVYYSYGLLNTYGSGGYAFYFFPEQQQFNSTLRLKELQGGKWLDEKTWAVIL
ELTTFNPDVNLFCSISVLFEVSQLGVVNSSISTHSFPLADFNRKTS---AEIYLYVAILI
FFLAYIVDEGYVILQEGASYMKSVYNLLNFALKCIFTLLIMLFVSKHFLATGVIQFYLSS
PEDFIPFHAVSQIDHTMRIILAFLLFLTILKTLRYSRFFYDVRLAQRAIQAALPGICHMA
FVVSVYFFVYMAFGYLVFGQHEWHYSNMIHATQTIFSYCVSAFQDTEFSSNRVLGVLFLS
SFMLVMICILINLFQAVILSAYEEMKQPVYEEPSDEVEAMTYLCRKLRAAFTFLIPQSKP
KDESEFLATMLYGQPEKNSHRYLGLKTRNINGKKMVYLVV

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------GPIYLVWFIPLQHPLLHL-
-----QWTFHLQLPGASLRPNRTFTYQDRIPSASRFIPRSVLPFHPDIYAGFMEKAECPT
DSLEPVILKASLDTYGSKVLESPVACIQN---PCFIHEVRI-KEGNPNLIELDGR--NPL
TLNT

PF02010 // ENSGT00700000104221_2_Domain_0 (305, 786)

AVKVNCSIPHTITQEWNFYSVPNMKT-PPDWSRPMKAQWIDQMKYYTFFQIPDRIL
ARGLYLINFTVTV--T--TTKKVLKKSAFVYLLMSKSELVAVI-KGDDFQRVHFNQSWTL
DGSASWDPES---KDPTE--GLDYRWYCTTDKSHLKSVIVPGSTRDTCLP-QLPDLRWIQ
ESGPVHTVLPGTLRGNQVYFFRLVIQKDERKAFADQKVVVIAGPPPAMSFSCIENCEKIL
IITDRFSLSGKCTDCGSA-LAYYLWSLLSYSGAEILFDWAHRTTTGRTNPYLSIKASAFK
GFSDQFCFISLKVSNWGGGVSVSNHSFYINSPPHVGHCNIHPDKGIALVTKFVVQCRNFR
DYNLPLGFKIIA-SNF-WNTDEISSLEQNTLGAVIYEGAHPVTPPSFLPIGVPANNYLVV
IYAQVYD-SLGAFSQVTLYATVNSPLIIHAPDTMLSHLLNLTQSSSGAMLTTLFQQRDFV
RAGYL

ENSGT00700000104221_2_Linker_0_1 (786, 1328)

AYLVASVLKDVKPLLDLQTDRFAIQERLISFCNRLPTNTLTEMNQVTVIILELTQ
NASGLTAGVQKAATSRLMEINLALQRHRQREKIFHSEQIEIVSTGISTSLSNIFKTG---
---INMDTVNETLSVTKLLADTISSIKVPGEVETVISTPNFKMHIKKDEKHNVT-KAALA
KKDCL-NCFYPTLRESNTSDLARESSISTVFYEFKGDPFPWLSKEE--SPSVDVVGFQMR
EIQENGDVSEAEPEVVEALILRKKLREALFKISVGPDKE------DLRTTTGIFTFLVH-
GGYKEVYIQIITEVRVLFTVLIYVGSNVTHKLPIASFLAPPDMPAVADE--SELFDPTCQ
V--DVPFLICLSQSLLQATAQGS-VSAHWNISVILRASYIVLKLNDNLVNISIFTVQCLN
MDGIQQEWGEKACRVGGSSCWWRAHCICRLKP-EATKGRKSRQLS--NQSSRIKYLTARM
VVIPNSIDLRLDIIWRLPQNPVTLFTVILVIFLYLLLAFWAMHKDQTDRFLREHVIILPD
NDPYDHI

PF01477 // ENSGT00700000104221_2_Domain_1 (1328, 1433)

CYLVTFYTGSRLGSGTKADVFIQLLGTKASSEVHCLSHPDFTTFYRGSMDTFL
LTTKSDLGAIRAIR-VWHNNEGSRPSWYLSRVKVENIFNRHIWLFLC-RSWL

ENSGT00700000104221_2_Linker_1_2 (1433, 1927)

WV-E---S
LEQTFEPVDKEQPLSKKDYFLIHSSNLLGNNHLWMSVFASVVTGPYNRLQRLSCCLSVLL
STLFCNIMFFKSDEEKEA-LPVELKHLQKVMRGIESALICEPLQMTISALFTYSQRKVSP
VPVTYAAP-RLHPFMKADFPNWKERLEMWYYHETGQPQTRSHGISTKKQAP--ETKGKLP
EQNAP------------------------HQE----R-KATD---------AEDRT----
LTEAGG-GASSSPPSQVGERGP---------HKGEPPKSRPKKVMLFES-KPRFVLHWWC
VYLAWLLVICSSGICSFFIIMYGLTYGYKKSMDWLFASVSSLCQSIFVIQVAKILLFSGV
K---SSRAKYCRN--ISWTTRYNY--IEIRLQGI---NLDADDTRE--LHYEII--RVRG
SRMYQPLMEDEIQIFKRRNRIKRGAIVFLSHIISHFIFLALLLCIAFLVSHSHTFHHNQA
IRRQFS

PF08016 // ENSGT00700000104221_2_Domain_2 (1927, 2365)

VN-LENVRELNDTYRWLNGV--LLPLVHNSQNPSFLSNSWSRILGLPRMRQVRA
KSIPKSCFLSGTAANRLMKKGIHCQSQYSKAREDRKSYSRFWTAPVGSSVDRN---LVSF
TYESKPGEWAYYSYGLAHAYGMGGYPFYFFPNQQQYNSTIRLQELWDSQWLDERTWAVIL
ELTTFNSETSLFCTISIVFEVSPLGVVNPNLAVHSFSLPLFRMRSQ---LELYLYGAAMV
FILVYLVVEVIIIYKEKKNYVRNVFNLLSFGLKSMFLFLIFLLYIQFRMAKKILGFYFQN
PDDFFPFHAISHVDQVLRITLGFLVFLTILKTLMYSRFFYDVRLAQRALLAALPAICHMA
LLVGVYIFVYVVFGYLVFGQHQWHYSSIIHSTQTIFSYCVSAFEGTAFLNKQILGGLFLS
SFMLVMICVLINLFQAVILSAYEEMKQLVYEEPAAEVEAMTYLLHKVRNLFRFLTCRAPA
KEEPAYFTDILYGHPENKSYQYLGLKSRKIDGKRMNYVVV

MSPGPALLLL-GV-G------LSLSVGRLPLPPAPRGAQAAVSGA----PGGLLRGAPGL
GVRGGRALLSL-RPSAVRAGGAVLSGRG----------SLCFPRGGTGR-----------
-RWYCLD--LRVLLSAQRLPWPAAPA-----LVDLQLSARGGRLSLTWSVRLPRSPGRL-
-----AWAFRLRLLGPGAARPASP-AAR--------VSPRSAAPGPRPQQGFVARTECPT
DGPA-RVMLQAVNSSSHRAVESSVSCQIN---ACVIQRVRI-NTDQKGAPVRL-SMKAEA
TIN

PF02010 // ENSGT00700000104221_2_Domain_0 (304, 786)

ASVQLDCPAARAIAQYWQVFSVPAVGQ-APDWTQPLDLPQLEIRNSPLFIHIPSNSL
QWGVYVFNFTVSITTG-NPKMPEVKDSDAVYVWIVRSSLQAVM-LGDANITANFTEQLIL
DGSTSSDPDA---DSPLQ--GLQFFWYCTTDPRNYRGDRINLGSKEVCHP-EQANLKWPW
ASGPVLTLLPETLKGDHVYFFRMVIRKDSRTAFSDKRVHVLQGPKAIAHITCIENCERNF
IVSDRFSLFLNCTNCAS-R-DFYKWSILSSSGGEMLFDWMGETVTGRNGAYLSIKAFAFR
HFLEAEFSISLYLACWSGVTSVFRHSFIINHGPQIGECKINPAKGIALITKFVVQCSNFR
DKHVPLTYKIIV-SDL-HSVGEISSVKENTLGTILYLGPQSTAPPSFLPVGTLASQYGLK
IYAQVYD-SLGAFSQVTLHATAQAPTDKNSSKTVLNQLLSFTVGPSS-LLSTLIQKQDFL
PAGYL

ENSGT00700000104221_2_Linker_0_1 (786, 1329)

LYIVASVLNNMKTELPLQDDRVNLRKHLIDQSFLLPVSTLVEIGQVVMTITKLTQ
KPSEFTWDAQKRATMRVWQANQALQEYQQKDKRFRSEQIEIVSTGILMSLSNILKMT---
--SP-HQVVKDPFYVIESLSDTILANKVPGNKTTSMRTPNFNMYVKKVEKWGIN-QLFRN
EKHCR-NCFYPTLNVSSVPGLSANGPVSTMFCDFTNDPFPWLNDQE--NTSVEVSGFRMT
GVADNGSVLEITPDVVEVYLVRKNLTFAAFNLTVGPNSE---VDGSLKKTTGGFSFQVDS
TVLREVLVHIVTEVMVLFTVLVYTGSQITPTALVATFLVPHDIPPVASQ--SALFDPACT
V--KKARVVCLPVSLLQLIAQHS-HSPHCTVSVVLQAPRFVMKLNDKLVRISIFSVQCLD
MYGIQSEWREGYCILGEKTSWHEVHCICK-KVVRARRQLGTIGLT--GIHLHTHYVMAKV
IVIPNPVDLRLNIIKSLHQNPVTLFTVLFIILLYVGLAFWALYRDEMDQHLRGHVIVLPD
NDPYDNLC

PF01477 // ENSGT00700000104221_2_Domain_1 (1329, 1445)

YLVTIFTGSRWGSGTRANVFVQLRGTVSTSDVHCLSHPHFTTLYRGSINTFL
LTTKSDLGDIHSIR-VWHNNEGRSPSWYLSRIKVENLFSRHIWLFIC-QKWLSVDT---T
LDRT

ENSGT00700000104221_2_Linker_1_2 (1445, 1927)

FHVTHPDEPLTRKDFFFIDVSSNLRKNHMWFSIFASVVAKTFNRLQRLSCCLAMLL
SSLLCNIMFFNLNRQEQT-ESRERKYMRSMMIGIESVLITIPVQLLITFLFTCSQRK-PQ
ADLNEVSPQKHPLMS-EASEHWEEYLRKWHAYETAKVHPREVA------KPASK------
--GKPRLPKASPK---------------------------ATSKP-KHRHRKAQIKTPET
LGPNTNS---NNNIEDDQDVHS---E-QHP--------S-QKDLQQLKK-KPRIVLPWWC
VYVAWFLVFATSSISSFFIVFYGLTYGYDKSIEWLFASFCSFCQSVLLVQPSKIILLSGF
R---TNKPKYCKN--LSWSTEYKY--TEIRLDGM---RMHPEEMQR--IHDQIV--RIRG
TRMYQPLTEDEIRIFKRKKRIKRRALLFLSYILTHFIFLALLLILIVLLRHTDCFYYNQF
IRDRFS

PF08016 // ENSGT00700000104221_2_Domain_2 (1927, 2362)

MD-LATVTKLEDIYRWLNSV--LLPLLHNDLNPTFLPESSSKILGLPLMRQVRA
KSSEKMCLPAEKFVQNSIRREIHCHPKYGIDPEDTKNYSGFWNEVDKQAIDES---TNGF
TYKPQGTQWLYYSYGLLHTYGSGGYALYFFPEQQRFNSTRRLKELQESNWLDEKTWAVVL
ELTTFNPDINLFCSISVIFEVSQLGVVNTSVSLHSFSLADFDRKAS---AEIYLYVAILI
FFLAYVVDEGCIIMQERASYVRSVYNLLNFALKCIFTVLIVLFLRKHFLATGIIRFYLSN
PEDFIPFHAVSQVDHIMRIILGFLLFLTILKTLRYSRFFYDVRLAQRAIQAALPGICHMA
FVVSVYFFVYIAFGYLVFGQHEWNYSNLIHSTQTVFSYCVSAFQNTEFSNNRILGVLFLS
SFMLVMICVLINLFQAVILSAHEGMKQPVYEEPSDEVEAMTYLCRKLRTMFSFLTSQSKA
KDEPEFFIDMLYGQPEKNSHRYLGLKTRNINGKKMVYLVV

MRPVTTLLLL--------GLGLGLGS-QLNPTPALLAALVTIPIT--GAPAGSMEGSQGI
GFLSGHVLFRLR-SRMAQGDSLFPSRGR----------GLAS------SHGPARRL----
-RTHRLH--VR--------VLAAAPT-----HVDLPLSAPRRLLAPQDLSPLRRSPSGP-
-----EWTFHLGLVRPREASSAPS-L----------SPCSIVPRGPHPNAGFLDQTKCPT
DGPM-PVALEAVSSDNSQATETSVSSQLSGNIICIIKNIKI-NGNEDGSPVVL-TRKMDL

PF02010 // ENSGT00700000104221_2_Domain_0 (301, 860)

SLNATAEYECPFAISVVHRWEIFSVSMMYD-VPDWSKPLDVPELQV----RNMHLPKGSL
SRGDYTVSFSVTLTTA-KPLVHVVSDFDYIYINIISSPLKAVI-SGGANIAINFTEELVL
DGSKSSDPDA---DSPLD--GLHFRWYCTTNRNNYRGRRITVRSKEVCHP-DQANLQWKG
VSDPVLRLLPKMLKGDRIYFFRMVITKGDRTAFSDMKVHVLQGQEPTANIECIENCDRIL
IISERFSLFLNCSSCSVSH-DVFKWSILSSSGKEMPFDWVGQTATGRNSDYLSIKAFAFR
EFLEAEFWIALDLDTWSGSILILKYPFVINRAPEIGECKINPANGTAFYTKFVVRCSDFK
DKNIPLTYKMIV-SDL-HGFAKISSLKENTLGSILYMGHAVNSPPSFLPAGVLANSYGIK
IYVQVYD-SLGAFSQVTLYATVRAPTDKNSSKTVLHQLLNFTMGPNS-AIPPLLQKQDFL
SAGYLTYVVASVLNSMKTKSTLQADKARLREYLVNQTFVFPMGNLMEISQVVMAVATLTQ
KPSEFTHMAQKLTTVRIWE

ENSGT00700000104221_2_Linker_0_1 (860, 1327)

ANQALQQHQQKNRHFDTEQIETVCTGILTSLSNILKMI---
--AH-HQVVKDPFHVLESLADTILAGKVPGNETTIMWTTSFNVYVKKTEKENVT-GILGN
EKHCQ-NCFRPALNVSSVPSLLANSPISMMFCEFAEDPFPWLSYQE--NISAHVVGFRMT
GTAAQGNMIEITPDVAEVYLGRKNLSFAAFSLIVGPDNEPSEVDESLRKTAGGFSFEVDS
GAGKEVLVHILTEVTVPFTVLVYAGSHVTPTALVATFLVPHDIPPIANQ--SDLSDPACT
V--KVARVVCLPPSLLKAIAQRS-QSTECAIAVVLKAPRFVTKLSDKLVRISLFYVHCLD
MFGIQSDWREDICVLGEMTTWDRVHCVCK-NTRRARRQLNTIGLA--NIPLHARYLTAKV
IVVPNPIDLRLEVTKEITYNLVTVITVLFIMLAYILLAFWALHRDESDQFLRDYAIVLPD
NDPYDH

PF01477 // ENSGT00700000104221_2_Domain_1 (1327, 1445)

VCYLVTIFTGSRCGSGTRANVFVQLRGTESTSDVHCLSHPHFTTLYRGSISTFL
LTTKSDLGDIHSIR-VWHDNEGRAPSWYLSRIKVENLFSRHIWLFMC-RKWLSIDT---S
LDRT

ENSGT00700000104221_2_Linker_1_2 (1445, 1926)

FQVTHPDEPLRRIDFFLINATDTLGKNHIWFSVFADVVSRPFSRLQRLSCCLAMLL
SSLLCNIMFFNLNTQGT--EAEGSGYIRSMVIGLESVLITIPVQVIITFLFTYSQSR-DR
ATLDEVSPREHPLML-VESEYWEERLEKWHAHETAEALAREAG------KLPPK------
--ESPGLHKSPSK---------------------------AASKR-GRQLKKAESKVV--
QRPNTNAN--NKTSKENEGVES---A-EPS--------S-QPGPPPLPT-KPSIVLPRWC
VYVAWFLVFATSSISSFFIVVYGLTYGYEKSLEWLFASFCSFCQSVFLVQPSKIILLSGI
R---LNKLKYCKN--LPWVNHYRY--TEITLQNM---TLHPDEMRK--QHDYII--YLRG
TRMYQPLTEDEIRIFKRKKRLKRRALLLLIFVLIHFIFLALLLWLVALLRHTDTFYYNQF
LRNRF

PF08016 // ENSGT00700000104221_2_Domain_2 (1926, 2238)

SVD-LATVTRLQDIYSWLNDV--LVPLLHNSLNPTFLPESASIILGLPLMRQVRA
KSGEKACLPAKNFAQTSIKGEIHCHPKYGADPEDTQNYTSSWIKISKRATDKN---TKGF
TYKPKETRWPYHSHGLLHTYGSGGYAFYFFPDQEQFNSTERLKGLRSSKWLDEKTWAVIL
ELTTLNPDANLFCSLSVVFEVSPLGVVNTSLSVHSFVLADFNRKTM---AEILLYAAILI
FFLAYVAHEGYVITQERTSYVKSVYNLFNFALKCVFAVLIVLFLRKHVLAAGLIQLHSSN
SAEFIPFHAVSQVDHAMR------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--

PF02010 // ENSGT00700000104221_2_Domain_0 (363, 860)

GVYIFNYTLSIKPS--SQLPPVEGSDILYVVVERRPLKAVL-LGPQNITVKFTALLVL
NGSTSNDPDV---GMAVQ--GLFYSWYCTTNPKNYQGDKITLMSKEVCGP-EQTSLRWVQ
------EIKPGTLAAGRVYYFRLVVKKDTRSAFADKTVHVLLGPAPEARLLCIENCEAVF
SISDRLSLFLNCSSCTLSR-DVYRWSLHSRTGGEIPFDWKGLTTTGRNRNYLSVKAFALS
DFPEDQYYISGRITAAEKFRD-FQHFFVINHAPRPGECKIKPRKGTSLATKFVVRCRDFK
DYNTPLKYKVIL-SDS-YDSRGRHSLRENIMRVSPYFGTQS-TTSFFLPVGLLVNRYSLK
IYVQVYD-SLGTFTQVTLASTVLPPTNRLSPETVLQKLHNLTMGPDS-KLSDLLKKKDFL
GAGYLIYIGASVLNSMRYNSSMQEDMVQHREHLVNQTFQLPLNTLEEITQVVAALAKLTQ
RVSAITN-AQGRSTERLSQ

ENSGT00700000104221_2_Linker_0_1 (860, 1327)

ANQALQEYRKRNKQFHSEQIDTVCTGIFRSLSNLLKLS---
--AH-HKAFEEPIYVLDSLADTVLASVMPENETKVLQSPGITMNVRKTGEWNCQ----LC
GEHSH-NDLYAKVNISSVPGLAENAPMSTTFIEFTEDPFSWIGNPE--NISTDVVGFRMS
ATTAKGEELEITQEIAEVYLTRKTVNSKVFNITMRPSTEYDVAGESSKTATGAFRFEVDC
SEQKEVLLHIITEVTLLFRVSVYAGDKVSATNLVATYLVPRDIPPMANH--SDLFDPNCT
V--KAARVVCLSPSLLQVIAERL-QSTYCVIAVVLQAPQFVLSPNNKLVRISVFRVQCLD
MYGIQSEWNEHSCTLGEKTSWQRVHCICKTKDTEQPK--RPPILS--NLRHTH-DIVAKV
IVVPNPVDLHLDVVKKITQNPVTLIAVIFILILYIILAFWALHRDETDQFIRQHVIILPD
NDPYDK

PF01477 // ENSGT00700000104221_2_Domain_1 (1327, 1445)

TCYLLTVFTGSRCGSGTRANVFVQLLGTESTSDVHCLSHPHFPSLYRGSINTFL
LTTRNNLGDIHSIH-VWHNNEGSSPSWYLSRIKVENLFSRKIWLFMC-REWLSIDT---S
LYRT

ENSGT00700000104221_2_Linker_1_2 (1445, 1926)

FYVSQPDQPVSRLDFFLIDMTYKMGKSHMWFSVFAAVISKQFNRLQRLSCCLSVLL
SSLLCNIMFLNLNPSEGM-ESPQDKYFRSMIIGMESTLITLPVQVIITALFNFSQRN-PL
VHEKRVGPRMIPEVV-DSGDNWGTILQMWYKKETSEPEKTRDEEQQRAASG---------
-----------------------------------------TQRS-RHRLKK--SS----
---TLNTNA-NPD------AHA---E-EPP--------Q-RLG-LHVQTTTRVV-LPHCF
VYLAWSLVFATXXXXXX-XXXXXXXXXXX-XXXXXXXXXXX-XXXXXXXXXX-XXXXXXX
XXX-XXXXXXXXXX-XXXXXXXXXX-XXXXXXXXXX-XXXXXXXXXX-XXXXXXXXXX-X
XXXXXXXXX-XXXXXXXXXXX-XXXXXXXXXX-XXXXXXXLLPLVAIL-RHKDTFHYNQF
ISDQF

PF08016 // ENSGT00700000104221_2_Domain_2 (1926, 2345)

SVD-LVTVTKLDDIYSWLDNM-PLP-LFHNDVKPTFLPDSSSKILGLPRMREVRA
KPGGKTCLPPKHFGKSRVSGEIHCHPQYGSDPEDTRNYSASWDTVANQAPEET---DSGF
TYKPTQRSWAYRSYGLSHTYGSGGYTFQFFPEEQQFNSTLRIKDLQSSHWLDEKTWAVIL
ELTTFNADSSLFCSLSVIFEVSQVGVVNTSLSAHSFSLADFNRDTS---SEIYLYVAILL
FLLAYIIDEVYVISQEGALYVRSVYNLVNFVFKSLFLVLAVLFIRKHALAMGVIQFYLSN
PVAFLPFHAVSQVDQFMRMILGFLLFLAFLKTLKYSRVFYNVRLAQRAIRAALPGICHMA
FVVSVYIFLYMAFGYLVFGQHEWNYSHLMHSTLTIFSYCVSAFHNTEFCNNRALGILLLS
SFILL-------------------------------------------------------
----------------------------------------

--------------------------------------RGRLRAQPLP--G---------
------AESSV-------------RGGG------------------TGG------LS---
-------------------PRT-AP-----------------------------------
--------------------------------------RG---------AGPTLPRRCPS
GAAA--RVLLKANSSDPAAAKATVSCQRA---PCAMQPVKI-NRKNKHAPLIL-SRKEEL
TLNV

PF02010 // ENSGT00700000104221_2_Domain_0 (305, 788)

TMSWDCPEAMVIRKSWLYFTVASVND-TPDWNHPVHLPRVRV-MKFSSIHIPKSAL
PYGVYVFNFTLSIIRW-DPTLPPLTDSDIIYIWVKKRPLKAVLLPSATSMTVNFSDELIL
NGTMSSDPEA---DIPTA--GLHFFWYCTTNPRYYVGNYIPVTTQDVCHP-EQDTLNWPW
AVGPVLTIPPETLRGNGVYYFRMVVRKQNRTAFSDKTVQVLKGLPPRAHISCIENCGSAL
VVSDRFSLFLDCTGCAS-H-DFYRWSILSRSGQEVTFDWAGQAVTGRNGAYLSIKAFAFR
NFLENGFWVSLHLLSWSGTTLNLRHPFFVNHGPQVGKCKIDPVKGISMVTKFVVECSDFK
DKNLPLEYKIIV-AEL-DSIGEISSVEEQTLGPIAYLGAQSTTPAFFLPVGVMSNHYSLK
LYAQVYD-SLGTFSQVTLHATVQVPTVRDSSKTILQQLFNFTTDPTS-PLSTLFQKQDWL
PAGYLIY

ENSGT00700000104221_2_Linker_0_1 (788, 1329)

VVASVLNNIKWELELQGDRAHLLEHLVNQSSVPAMSTLDEICQVVMVITKLTQ
EASGSGQAVSEGATLRLWQANQALQAYQRKNQYFHSRHIEIVGTGILASLSNILKLI---
--NP-YYVFQDPFYVVEALSDTILANKVPGSETTVMRTSNFNMYVEKVENSHVA-KVFRN
ETLCP-NCLHATLNASRVPSLPSNAPISTMFCEFTDDPFPWLTYPE--NISAEVVGFRMT
GATDNGSVIEITPDVAEVYVVRKDLTFASFNLTVGPGID---SAGFSKITTGGISFEVDS
RGTGGVLIHIVTKVTVLFKALIYAGSQVTPTNLVGTFLVPHDIPPIVKW--NGQFDSTCP
T--KEARVVCLPSSLLRIIAERH-HSFKYNISMVLQAPRFVFKPTNKLVRIALFMVHCLD
MYGIQSDWREGTCVLGEKTTWRKAHCVCR-NVGRSRRQLASVRMA--YLHLHTHFVTAKV
IVVPNPVDLQLKVITNLDQNPATFLAVIFIMILYVILAFWALHRDVMDQYLRDHVVVLPD
NDPFDNIC

PF01477 // ENSGT00700000104221_2_Domain_1 (1329, 1436)

YLVTIFTGSRLGSGTRANVFIQLMGAESTSDVHCLSHPYFRTLYRGSINTFL
LTTKNDLGDIHSIR-VWHDNEGKAPSWYLSRIKVENLFSRRIWLFVC-RKWLSVD

ENSGT00700000104221_2_Linker_1_2 (1436, 1927)

T---T
LDATFPVTNPDEPLRRTDFFLIDLSHKLGKNHMWFSVFTDVVPRPFNRLQRLSCCLAMLL
SSLVCNIMFFNLNRKEQT-QSREGRIIRSMMIGIESVLITIPVQLLITFFFTYSQKE-PR
VNLDKVAPQKHPLMS-EEGLFWKERLDKWHKYEMEALANKAKST-SATRAKSSK------
----------------------------------------RAPK---------TSQKNNT
QKSNRN--FSNNNIEDSEDASS---KASST--------Q-LETTEPVKN-KTQIILPRWC
VYIAWFLVFTTSGISSFFIVFYGLTYGYDKSVEWLFASLCSFCQSVFLVQPGKILLVSGT
R---TKNPKYCKN--ISWSSKYHY--TEIRLQET---KMSPEEMQQ--LHEAMD--YLRG
SSIYQPITEDKIQILRRKKRIKRRSLLFLSYLVTHFIFLTLLLLLIVSLRHNDSFYYNQF
IRHQFS

PF08016 // ENSGT00700000104221_2_Domain_2 (1927, 2365)

VG-LATVMKLGDIYTWLHSV--LLPLLHNDLNPTFLPDSSSKILGLPLMRQVRA
KPSNKTCLLAKKFVQRSIAGEIHCHPQYGIDPEDTRHYSSVWNKAGKRSTDQS---SNGF
TYKPPGKKWVYHSYGVLNTYGSGGYTFDFFPEQPMFNSTLRLKELEGKNWLDEMTWAVIV
DLTTLNPDASLMCSVSVVFEVSPLGIVNSSLSVYSFSLADFNRETS---AEIYLYVAILI
FFCAYVVDEGYVITQERASYFRSVYNLLNLALKCMFTLLIVLFFQKHLLATSMVRLYLSD
PETFIPFHAVSRVDQFMRIILAFLLFLTILKTLRYSRFFYNVRLAQKTILAALPGICHMA
LMVSMYSFMYVAFGYLVFGQHEWNYSNMIHATQTIFSYCVSAFQNTEFSSNRVLGVLFLS
SFMLVMICIFINLFQAVILSAYDEMKQPVYEEPSDEAEAITYLCDKLRSGFDFLTSRSRD
KDQSEFFVDMMYGQPEKNSRRFLGLKTRNISGKKMVYLVV

MWPGPALLLL----------GLGLGLGRLPSSPGPRGLLGVLRGAPGLGQD---------
------EESRV-------------RGGG------------------TGG------LS---
-------------------PRTTAP-----------------------------------
--------------------------------------RR---------AGPKLPHKCPS
GAPA--RVLLKVNSSNPAAATATVSCQMT---PCNIQSVKI-NRKDQHAPLIL-SRKEEV
TLNVT

PF02010 // ENSGT00700000104221_2_Domain_0 (306, 788)

VLWDCPEAMIISKTWLYYLVASVND-TPDWNRPVQLPQVRE-MKLSSIHIPKSAL
PYGVYVFNFTLSIIRW-NPTLPTLRDSDSVYIWVKKPPLKAILLPGATDMTINFSDELIL
NGSMSSDPEV---DIPTE--GLHFSWYCTTNPIYYVGNYVQVTHQDVCHP-EQDTLNWLW
AVGPVLTIPPETLRGNGVYYFRMVIQKQNRIAFADKIVRVLKGLLPKAHISCIENCGPTL
VVSDRFSLFLNCTGCAS-Q-DLYSWSILSRSGHEMMFDWAGQAVTRRNGAYLSMKAFAFR
NFSEAGFWVSLYLTSWSGATLNLHYPFAINHGPQVGKCKINPAKGISMVTKFVVECSDFK
DKNLPLKYKIIV-AEL-DNIGEISSVEENTLGTIAYSGTQSTTPAFFLPVGVMANHYSLK
LYAQVYD-SLGTFSQVTLQATVQGPTVKDSPKTVLRQLLNFITNPSS-PLATLLQKQDWL
PAGYLMY

ENSGT00700000104221_2_Linker_0_1 (788, 1329)

VVASVLNNIQRELALQNNRAYLLEHLVNQSFVPALGTLDQICQVVMVITKLTQ
EASDYSQAASVGATLRLWQANKALQAYQRRNKHVHSRHIEIVGTGILTSLSNILMQV---
--NP-HYEFQDPFFIVESLSDTILANKVPGSETTVLRTSSFNMYVEKAENSNVS-KVFRN
ETRCP-NCLQATLNTSRVPGLPPKAPISVMFCEFTNDPFPWLTYPE--NISASVVGFRMT
EATDNGSVIEITPDVAEVYLVRKDLTFASFNLMVGPGIE---GTRFSKMTTGGISFEVDS
RGTGQVLIHIVTKVTVLFKALIYVGSQVTPTNLVATFLVPHDIPPTAKW--SSLLDSTCP
V--KEARVICLPSSLLRILAQRS-HSFKYNISMLLQAPRFVFKPTNKLVRIALFMVHCLD
MYGIQSDWKEGTCVLGEKTTWKKVHCICR-NVRRSRRQLASMK-----LHLHIHFVTAKV
IVVPNPVDLQLQVIRNLYQNPVTFLVVLFIMILYGILAFWALHRDAMDQYLRDHVVVLPD
NDPFDSIC

PF01477 // ENSGT00700000104221_2_Domain_1 (1329, 1436)

YLVTVFTGSRFGSGTRANVFIQLMGTERTSDVHCLSHPYFITLYRGSINTFL
LTTKNDLGDIHSIR-VWHDNEGKAPSWYLSRIKVENLFSRRIWLFLC-RRWLSVD

ENSGT00700000104221_2_Linker_1_2 (1436, 1927)

T---T
LNATFSATNPDESLKRIDFFLIDLSHKLSKNHMWFSVFSDIVPKSYNRLQRLSCCLAMLL
SSLVCNIMFFNLNRKGQT-ESRERRIIRSMMIGIESVLITIPVQLLITFFFTYSQKK-PP
VNLDKVVPQTHPLMS-EEGLFWKERLDKWHEYEMKALDNKAAESTSAPRGKPLK------
----------------------------------------RTFKT-SRKSKKTDSKGSDT
PKSNSN--FSNNNVEDSESGSL---KVSST--------Q-LVTTQPVKN-KTQILLPMWC
VYIAWFLVFATSGISSFLIVFYGLTYGYDKSVEWLFTSFCSFCQSVFLVQPSKILLWSGI
R---TKNLKYCKN--LSWSSKYRY--TEIRLQEA---RMSPEELQQ--LHEDMN--YLRG
SSIYQPITEDKIQILRRKKRIRRRSLLFLSYLVTHFIFLALLLLLIVSLHHNDSFYYNQF
IRQQFS

PF08016 // ENSGT00700000104221_2_Domain_2 (1927, 2365)

MD-LATVMKLGDIYTWLNSV--LLPLLHNDLNPTFLPDSSSKILGLPLMRQVRA
KPSNKTCLLAKKFGQKRIAGEIHCHPQYGIDPEDTKSYSSVWNKAAKQSTGKP---SNGF
TYKPPGKKWVYHSSGVLNTYRSGGYAFYFFPTQQSFNSTLRLKELEGKNWLDEMTWAVIV
ELTTLNPDTSLMCSISVVFEVSPLGVVNSSLSVYSFSLADFSRENW---AEIYLYVAILI
FFCAYVVDEGYIIMHERASYLRSVYNLLNFSLKCMFTLLIVLFFQKYLLATSMVQLYLTD
PKAFIPFHAISQVDHFIRITLAFLLFLTTLKTLRYSRFFYDVRLAQKAIQAALPGIFHMA
LVVSMYSFMYVAFGYLVFGQHEWNYSSMIHATQTIFSYCVSAFQNTEFSSNKVLGVLFLS
SFMLVMICIFINLFQAVILSAYDEMKQPVYEEPSDEAEAITYLFDNLRSGFDFLTSRSRD
KDQSEFFVDMMYGQPEKNNRRFLGLKTRNINGKKMVYLVV

MRPGSALLLLL---------GL--SLGLLPPPVAPRWAPAAVAGPSASPSGGLFRSAPGS
GDRGDSTGLIL-RPRVARDGGVLWSGSR----------YLCFPRDGADRAGGGRRVSPRP
PGRYCLG--VRVLLRGQ--PGPAAPT-----RVDLRVWAPRGRLSLVWSARLP----QP-
LGAL-AWVFQLWLFGPGAARPTRD-ASSTARL-S---PRSALLADPRPNTGFVAQTKCPT
DGPT-PIVLEAVDSPNYTAVESSVSCQLK---RCSIQSVKI-NTNNDGSPVIL-GWKESA
TINA

PF02010 // ENSGT00700000104221_2_Domain_0 (305, 787)

SVVHDCFFYLSMRHLWQYYSVPSVND-KPDWTQPLYLPHIQLMRNPLFIHIPKSSL
PVGVYVINFTLTITTR-TQNQSVLQDSDAIYLWVVKRPLRAII-LGNEVETVSFTDQLVL
DGSTSFDPDA---DDPQE--GLRFSWYCTTNSQNYHKDQIAVMNKEVCLP-EQASLKWPG
TPGSVLTLLPETLKGGHMYFFRMVIQKGHKTASSDKTVQVLQGPKIVAQISCIENCDRNL
ISSDRFCVFLNCTNCAS-R-DSYKWSLLSSSGSEMLFDWTAQTMTGRNSAYLSLKAFALH
HFPEAEFSVSLHVASWSGDSSVFRYVFIINHGPQTGKCKINPTKGVALVTKFVVQCSNFK
DNHIPLTYKIIV-SYL-HGLGEISSVRENTLGTILYLGPESTAPPSFLPVGVLANHYATK
IYVQVYD-SLGAFSQVILYATVQAPTDKMSSKTVLHQLFNLTSGPDS-VLSTLLQKQDFL
PAGYLM

ENSGT00700000104221_2_Linker_0_1 (787, 1327)

YIVASILNNMKAESPLEHDKLSLREHLVNQSYLLPLNTLVQISQAVTTITKLIQ
KPSEFTGAAQRYGTVRLWQADQGLQEYQRNDKHFRSEQIEIITTGTLTSVSNILKLT---
--GR-QKMVKDIFYVIESMADTILAGKVPGNST-FMRTPNVNMYIKKAEKRDVT-KVFRN
QKHCQ-NCFYPTLNVSSVPDLPANALVSTMFCEFAEDPFPWLNDQE--NASVKVVGFRMT
GE-HNGTMIEITPDVVEVSLFIKNLTFAIFNLTLGPNKE---VDGALKKTIGAFSFEVDS
NVLREVMVHIMTEVTVFFKVLVYAGSQITSTALVASFLVPHDIPPIASQ--SVPFDPACP
V--KQARVVCLSLSLLQLIAQRS-RSSQCAVSVVLQAPRFLLEPTDKLVRISLFSIQCLD
MYGIQGEWREDYCIPGEKSTLANVYCICR-WPTRAKRQAGTFWLS--DLPLHTRYVMAKM
IVYPNYVDLRLVVIKNVYQNPVTLITVLFIIFSYMVLAFWALHRDEMDQFLRGRAIVLPD
NDPYDD

PF01477 // ENSGT00700000104221_2_Domain_1 (1327, 1441)

VCYLVTVFTGSRCGAGTKADVFLQLQGTESTSDVHCLSHPQFTTLYRGSISTFL
LTTKSDLGDIHSIR-VWHNNEGKAPSWYVSRIKVENLFSRHIWLFMC-RKWLSIDT---T

ENSGT00700000104221_2_Linker_1_2 (1441, 2158)

LDRTFHAISSDQPLRRRDFFLIDLSKNLGKSHLWFSIFAAIIPKSFNRLQRLSCCLAMLL
SSLLCNIMFFNLNKEE-N-ESRQWRYVRSMMIGIESVLLTIPVQLLITFLFTYSQKK-PL
VSLDQVSPQKNPVTS-EDSGHWEDRLGNWHAHETAATETREATETREAAKPVSK------
--RKSQLPKHSIR---------------------------STFKS-KRQQEKAKTKSRKS
QRQNANSNNSNNNANEDVNS-----E-EHA--------S-QENLPHPIK-EPQVVQPWWC
IYIAWFLVFATSSISSFFIVFYGLTYGYEKSMEWLFTSLCSFLESVLLVQPAKIILLSGI
R---ANIPKYSKN--LSWSNLYRY--TDITLPGV---NMHPDEMER--IHDQVR--QLQG
SRMYQPLTEDEIRIFKRKKKIKLRALLFLSYIVTHLIFLALLLVLIVLLRHTDSFYYNQF
LHDQFSVG-LAAVTKLEDIYRWLKNV--LVPLLHNDLNPTFLLDSSSKILGLPLMRQVRA
KSSEKGCLPAENFVQNSIKREIRCHPEYGVDPEDTKDYSSSWNEINKWDTDRN---TSGF
TYKPQEKQWVYYSYGLLHTYGSGGYAFYFFPGEQQFNSTLRLKELQESNWLDEKTWAVIL
ELTTFNPDVTLFCSISVIFEVSQLGVVNTSISLHSFSLATFDRKTS---AEIYLYAA

PF00520 // ENSGT00700000104221_2_Domain_2 (2158, 2358)

ILI
FFLAYIVDEGYIIMHEGASYVRSVYNLLNFALKCIFTVLIVLFLRKHFLATDMIQLYKSQ
PENFIPFHVVSQVDHTMRIILGFLLFLTILKTLRYSRFFYDVRLAQRAIQAALPGICHMA
FVVSVYFFVYMAFGYLVFGQHEWNYSNMIHATQTVFSYCVSAFQNTEFSENRILGVLFLS
SFLLVMICILINLFQAVILSAYEDMKQPVYEEPSDEVEAMTYLCYRLRTMFSFQTSQDRA
KEEPKFFVNMLYGQPEKKNRRFLGLKTRNINGKKMVYLVV

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------MDWLFASFCSFCLSVLLEQPCKIILLSGF
R---AGRPKYCKN--LSWTSKYCY--IEIELQGA----VNRKERKR--RHQQIL--ELRR
SRMYQPLTKDEILIFKRKKAIKRRAFLFLCYVLTHFIFLALLLRLVALLHHTDSFYYNQF
VRDRFS

PF08016 // ENSGT00700000104221_2_Domain_2 (1927, 2227)

VD-LGSVTKLEDIYRWLNSV--LVPLVHNDPNPAFLPDSSSKILGLPLLRQVRA
RPGDKLCLPA-NFAQTSMGREIHCHPSYGTDPEDTRSYSGLWNQVLKRPEDKN---TNGF
TYKPPGKIWGYVSHGLLHTYGSGGYAFYFFPEQQPFNSTVRLRELQSSEWLDENTWAVIL
ELTTFNPDVSLFCSISVVFEASQLGVVNTSLSVHSFSLADFDRETS---AEIYLYVAILI
FFLAYVVDEGYIIMQERASYVRSVYNLLNFALKCIFTVLIVLFFRKHFLATGIIRFYLSH
PEDFIPF-----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------

MRPGPALLLL-GV-G------LSLSVGRLPLPPVPRGAQAAVSGA----PGGLLRGAPGL
GVRGGRALLSL-RPSAVRAGGAVLSGRG----------SLCFPHGGTGR-----------
-RWYCLD--LRVLLSAQRLPWPAAPALA---LVDLQLSARGGRLSLTWSVRLPRSPGRL-
-----AWAFRLRLLGPGAARPASP-AAR--------VSPRSAAPGPRPQQGFVARTECPT
DGPA-RVMLQAVNSSSHRAVESSVSCQIN---ACVIQRVRI-NTDQKGAPVRL-SMQAEA
TIN

PF02010 // ENSGT00700000104221_2_Domain_0 (304, 786)

ASVQLDCPAARAIAQYWQVFSVPAVGQ-APDWTQPLDLPQLEIRNSPLFIHIPNNSL
QWGVYVFNFTVSITTG-NPKMPEVKDSDAVYVWIVRSSLQAVM-LGDANITANFTEQLIL
DGSTSSDPDA---DSPLQ--GLQFFWYCTTDPRNYGGDRIILGSKEVCHP-EQANLKWPW
ASGPVLTLLPETLKGDHVYFFRMVIRKDSRTAFSDKRVHVLQGPKAIAHITCIENCERNF
IVSDRFSLFLNCTNCAS-R-DFYKWSILSSSGGEMLFDWMGETVTGRNGAYLSIKAFAFR
HFLEAEFSISLYLACWSGVTSVFRHSFIINHGPQIGECKINPAKGIALITKFVVQCSNFR
DKHVPLTYKIIV-SDL-HSVGEISSVKENTLGTILYLGPQSTVPPSFLPVGMLASQYGLK
IYAQVYD-SLGAFSQVTLHATAQAPTDKNSSKTVLNQLLSFTVGPSS-LLSTLIQKKDFL
PAGYL

ENSGT00700000104221_2_Linker_0_1 (786, 1329)

LYIVASVLNNMKTELPLRDDRVNLRKHLIDQSFLLPVSTLVEIGQVVMTITKLTQ
KPSEFTWDAQKRATMRVWQANQALQEYQQKDKRFRSEQIEIVSTGILMSLSNILKMT---
--SP-HQVVKDPFYVIESLSDTILANKVPGNKTTSMRTPNFNMYVKKVEKWGIN-QLFRN
EKHCR-NCFYPTLNVSSVPGLSANGPISTMFCDFTNDLFPWLNDQE--NTSVEVSGFRMT
GVADNGSVLEITPDVAEVYLVRKNLTFAAFNLTVGPNSE---VDGSLKKTTGGFSFQVDS
TVLREVLVHIVTEVMVLFTVLVYTGSQITPTALVATFLVPHDIPPFASQ--SALFDPACT
V--KKARVVCLPVSLLQLIAQHS-HSPHCTVSIVLQAPRFVMKLNDKLVRISIFSVQCLD
MYGIQSEWREGYCILGEKTSWYEVHCICK-NVVRARRQLGTIGLT--GIHLHTHYVMAKV
IVIPNPVDLRLNIIKSLHQNPVTLFTVLFIILLYVGLAFWALYRDEMDQHLRGHVIVLPD
NDPYDNLC

PF01477 // ENSGT00700000104221_2_Domain_1 (1329, 1445)

YLVTIFTGSRWGSGTRANVFVQLRGTVSTSDVHCLSHPHFTTLYRGSINTFL
LTTKSDLGDIHSIR-VWHNNEGRSPSWYLSRIKVENLFSRHIWLFIC-QKWLSVDT---T
LDRT

ENSGT00700000104221_2_Linker_1_2 (1445, 1927)

FHVTHPDERLTRKDFFFIDVSSNLRKNHMWFSIFASVVAKTFNRLQRLSCCLAMLL
SSLLCNIMFFNLNRQEQT-ESRERKYMRSMMIGIESVLITIPVQLLITFLFTCSQRK-PQ
ADLKEVSPQKHPLMS-EASEHWEEYLRKWHAYETAKVHPREVA------KPASK------
--GKPRLPKASPK---------------------------ATSKP-KHRHRKAQIKTPET
LGPNTNS---NNNIEDDQDVHS---E-QHP--------S-QKDLQQLKK-KPRIVLPWWC
VYVAWFLVFATSSISSFFIVFYGLTYGYDKSIEWLFASFCSFCQSVLLVQPSKIILLSGF
R---TNKPKYCKN--LSWSTKYKY--TEIRLDGM---RMHPEEMQR--IHDQIV--RIRG
TRMYQPLTEDEIRIFKRKKRIKRRALLFLSYILTHFIFLALLLILIVLLRHTDCFYYNQF
IRDRFS

PF08016 // ENSGT00700000104221_2_Domain_2 (1927, 2365)

MD-LATVTKLEDIYRWLNSV--LLPLLHNDLNPTFLPESSSKILGLPLMRQVRA
KSSEKMCLPAEKFVQNSIRREIHCHPKYGIDPEDTKNYSGFWNEVDKQAIDES---TNGF
TYKPQGTQWLYYSYGLLHTYGSGGYALYFFPEQQRFNSTLRLKELQESNWLDEKTWAVVL
ELTTFNPDINLFCSISVIFEVSQLGVVNTSISLHSFSLADFDRKAS---AEIYLYVAILI
FFLAYVVDEGCIIMQERASYVRSVYNLLNFALKCIFTVLIVLFLRKHFLATGIIRFYLSN
PEDFIPFHAVSQVDHIMRIILGFLLFLTILKTLRYSRFFYDVRLAQRAIQAALPGICHMA
FVVSVYFFVYMAFGYLVFGQHEWNYSNLIHSTQTVFSYCVSAFQNTEFSNNRILGVLFLS
SFMLVMICVLINLFQAVILSAYEEMKQPVYEEPSDEVEAMTYLCRKLRTMFSFLTSQSKA
KDEPEFFIDMLYGQPEKNSHRYLGLKTRNINGKKMVYLVV

MRPGPALLLL-GL-------GLGLSLGRLPLPPAPREAQAAVSGA----PGGLLRGAXXX
XXXXXXXXXXX-XXXXXXXXXXXXXGRG----------SLCFPRGGARW-----------
-RWYCLV--LRVLLSAQRLPRPAAPT-----LVDLQLTARGGRLSLTWSAPLPRWPRRL-
-----AWAFRLRLLGPGAARPGSP-AIR--------VFPRSAAPGPRPQPGFVARTECPT
DGPA-RLMLQAVNSSRHRAVESSVSCQIN---TCVIQRVRI-NTDQRGAPVRL-SMKAEA
TLN

PF02010 // ENSGT00700000104221_2_Domain_0 (304, 786)

ASVQLDCPAALAISQYWQVFSVPAVGD-APDWTQPLDVPQLEIRKSPMFIHIPSNSL
QWGVYVFNFTVSITTR-NPKMPEVKDSDAVYVWIVRSSLQAVM-LGDVNITANFTEQLIL
DGSTSSDPDA---DSPLQ--GLQFFWYCTTDPRNYRGDGIILGSKEVCHP-EQATLKWPW
ATGPVLTLLPETLKGDHVYFFRMVIQKDSRTAFSDKRVHVLQGPKAIAHITCIENCERTF
IVSDRFSLFLNCTNCAS-R-DFYTWSILSSSGGEMLFDWMGETVTGRNSAYLSIKAFAFQ
HFLEAEFSISLHLASWSGVTSVFRHYFIINHGPQIGECKINPAKGIALITKFVVQCSNFR
DKHVPLTYKIIV-SDL-HSVGEISSVKENTLGTILYLGPQSTSPPSFLPVGMVANQYALK
IYVQVYD-SLGAFSQVTLHATAQAPTDKNSSKTVLNQLLSFTMGPSS-LLSTLIQKQDFL
PAGYL

ENSGT00700000104221_2_Linker_0_1 (786, 1329)

LYIVASILNNMRTELPLQNDRVNLRKHLINQSFLLPVSTVVEIGQVVMTITKLTQ
KPSEFTWDAQKRATMRIWQANQALQEYQQKDKRFRSEQIEIVSTGILMSLSNILKMT---
--SP-HQVVKDPFYVIESLSDTILANKVPGNKTTSMRTPNFNMYVKKVEKWGVT-QVFRN
EKHCR-NCFYPTLNVSSVPGLSVNAPISTMFCDFTNDPFPWLNDQE--NTSVQVFGFRMT
GVADNGSVLEITPDVAEVYLVRKNLTFAAFNLTVGPNGD---VDGSSKTTTGGFSFQVDS
RVLREVLVHIVTEVMVLFMVLVYTGSQITPTALVATFLVPHDIPPVASQ--SALFDPACT
V--KKARVVCLPVSLLQLIAQHS-HSPHCTVSIVLQAPHFVMKPNDKLVRISIFSIQCLD
MYGIQSEWREGYCVLGEKTSWHDVHCICK-NIVRARRQLGTVGLT--NIHLHTHYVMAKV
IVIPNPVDLRLNIIKSLHRNPVTLFTVLSIILLYVILAFWALYRDEIDEHLRGHVIVLPD
NDPYDNLC

PF01477 // ENSGT00700000104221_2_Domain_1 (1329, 1445)

YLVTIFTGSRWGSGTRANVFVQLRGTVSTSDVHCLSHPHFTTLYRGSINTFL
LTTKSDLGDIHSIR-VWHNNEGHSPSWYLSRIKVENLFSRHIWLFIC-QKWLSIDT---T
LDRT

ENSGT00700000104221_2_Linker_1_2 (1445, 1927)

FHVTHPDEPLTRKDFFFIDVSSNLQKNHMWFSIFASVVAKTFNRLQRLSCCLAMLL
SSLLCNIMFFNLNRQEQT-ESRERRYMRSMMIGIESVLITIPVQLLITFLFTYSQRK-PQ
ADLKEVSPQKHPLMS-EASEHWEECLTKWHAYETAKAHPREVA------KPASK------
--GKPRLPKASPK---------------------------ATSKP-KHRHRKAQIKTPET
PRPNTNS---NNNIEDNQDVHS---E-EHP--------S-QQVLQQLKK-KPRIVLPWWC
VYVAWFLVFATSSISSFFIVFYGLTYGYDKSMEWLFASFCSFCQSVFLVQPSKIILLSGF
R---TNKLKYCKN--LSWSTKYKY--TEIRLDGM---RMHPEEMQR--IHDQIV--RIRG
TRMYQPLTEDEIRIFKRKKRIKRRALLFLSYILTHFIFLALLLILIVLLRHTDSFYYNQF
IRDRFS

PF08016 // ENSGT00700000104221_2_Domain_2 (1927, 2365)

MD-LANVTKLEDIYRWLNSV--LLPLLHNDLNPTFLPESSSKILGLPLMRQVRA
KSSEKMCLPAEKFVQNSIRREIHCHPKYGIDPEDTKNYSGFWNEVDKQAIDES---TNGF
TYKPQGKQWLYYSYGLLHTYGSGGYALYFFPKQQQFNSTLRLKELQESNWLDEKTWAVVL
ELTTFNPDVNLFCSISVIFEVSQLGVVNTSISLHSFSLADFDRKTS---AEIYLYVAILI
FFLAYVVDEGYIIMQERASYVRSVYNLLNFALKCIFTVLIVLFLRKHFLATGIIQFYLSN
PEDFIPFHAVSQVDHIMRIILGFLLFLTILKTLRYSRFFYDVRLAQRAIQAALPGICHMA
FVVSVYFFVYMAFGYLVFGQHEWNYSNLVHSTQTVFSYCVSAFQNTEFSNNRILGVLFLS
SFMLVMICVLINLFQAVILSAYEEMKQPVYEEPSDEVEAMTYLCRKLRTMFSFLTSQSKA
KDEPEFFTDMLYGQPEKNSRRYLGLKTRNINGKKMVYLVV

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----A

PF02010 // ENSGT00700000104221_2_Domain_0 (486, 788)

LRLPPETLEGGRVYHFRMVTQKGHKALFSDHSVYVLRGPAPTAHIACIENCARML
AVSRRFFLFLNCTNCGR-R-DVYSWSISSVSGETLPFNWSQQTITGRDSAYLAVRAFAFQ
SFAEAEFWVSVSLRSWGGVTSEFRRSFMVNHGPHVGQCRVSPAKGIAMFTEFVVKCNRFK
DKHAPVSYKITV-FDL-DRVGDINSGQENTLGTIVYWGTQTTTPPFFLPAGSAAHQYTLK
LSARVYD-SLGAFTQATVSVTVWPPTAISSAESVWRQILGVTTGPAS-LLSTLLQQQDWL
PASYLMS

ENSGT00700000104221_2_Linker_0_1 (788, 1329)

VVASVMNSMSTERTLSDDRAQLREHLINQSFGLPLRTSEEVGQVVVAIAKLTQ
EASEVTQVAQKRAMVRLQQANQALQTYQWEDEHRSAKQIETVGAGIVTGLSNILKLA---
--AP-QEVLEDLLFVVESLSDTIVAHKVPGSDATVLRTPSFSMHVEKAVKWDLA-QAFGK
DKHGR-NWFHATLNASRVPGLAANAPVSVMVCEFTHDPFPWLSYPE--SISTEVDGFRMT
GATDNGSVVEIMPDTVEMYLTRKNLTSVTFGLTLGPDPK---DVGSSKMTTGGFSFEVDS
GGVREVLVHIVTNETVLLTVLVYVGHHVTPNYLAANFLVPHDTPPVVTQ--SDLFDPACA
V--KVARVVCLPQSLLQVMARHS-HSPKYNVSVVLRAPSSALEPTDRLVQISIFSARCLD
MYRTQSEWREDACMLGEKTTWDKVHCTCR-DIGRTRRQPRML--P--RVPLHMHYVTAQV
VSIPNPVGLPGAVTADCQHNPVTLLTVLFIMLVYTGLASWALCRNKVDRVLRDCVIVLPD
NNSNDSVC

PF01477 // ENSGT00700000104221_2_Domain_1 (1329, 1445)

YVVTVFTGSRCQAGTRANVFVQLRGTHSTSDVHCLSHPHFRTLFRGSVSAFL
MTAKRDLGDIHSIQ-VWHDNGGQAPCWYLSRIKVENVFSGHIWLFMC-RKWLSIDT---T
LDRT

ENSGT00700000104221_2_Linker_1_2 (1445, 1927)

FHVLRPEEPVGRKDFFLIDLPHKLRTHHAWFSVFAGFVPKPFSRLQRLSCCLAVLL
SSLFCNSVLFNLNRHEQA-ASREGRYTRSMVIGTESVLITLPVQMLITFFFTHSQRI-PQ
GGRDE------QALVLEGSGCWEEGLCKWYTHRGTRGASKPTL-----------------
----------------------------------------------KHQHEKADSDA---
-------NVHNRNTGDTHDVPS---GEPP---------S-HQGPKRCQT-QCWIALPWWC
VYTAWFFVLATSTASSFFIIFYGLTYSSDESVEWLFASICSFCQSVFLVQPLKIILESGI
R---TNKPTYCKD--LAWATEHPS--CEIKLCGL---RMPRDEARK--LREHVA--QLRA
SRRYQPLTEDEVRIFRRFRRVRRRAILFLSYLMTHYIFMALLLLLIVRLRHTDSFYYNQF
ILGRFS

PF08016 // ENSGT00700000104221_2_Domain_2 (1927, 2365)

RD-LAAVTKPEDIYRWLSLA--LLPLFHNSQNPTFLPDSSSKILGLPRMRQVRA
KPTEKTCPPAKSFMQYNLAGEIHCHPAYGTDPQDTGNYSRFWSEVDKQATGMN---TEGF
TYKPQGKTWVYYSYGLLNTYGSGGYVFYFFPEQQQLNSTLRLLRLQQSNWLDEKTWAVIL
ELTTFNADSSLFCSISIIFEVSQLGVINASISTQSFSLAEFHRESS---AEIYLYAAILI
FFVAYIVDEGYVIMQERISYVKSIYNLLNFALKCIFTMLVTLFFRKYFLATGMIQFYLSN
PHDFVPFHLVAQVDHTMRITLAFLLFLTILKTLRYSRFFYDVRLAQRVIQAALPGICHMA
VVVSVYFFVYMAFGYLVFGQHEWNYSNLIHATQTIFSYCVSAFQNTEFSNNRVLGVLFLS
SFLLVMVCLLINLFQAMILSAYEDMKQPVYEELSEEVEVMSYLYHKLRKVFSFLAPNAQT
RDEPEFFIDMLYGKPEKNSCRYLGLKTRNINGKKVVYLVV

MRPGPALLLL-GL-GLGLGLGLGLSLGRLPLPPAPREAQAAVPGA----PGGLLRGAQGL
GVRGGRALLSL-RPSAVRAGGVVLSGRG----------SLCFPRGGARW-----------
-RWYCLV--LRVLLSAQRLPRPAAPT-----LVDLQLTARGGRLSLTWSAPLPRWPRRL-
-----AWAFRLRLLGPGAARPASP-AAR--------VFPRSAAPGPRPQPGFVARTECPT
DGPA-RLMLQAVNSSRHRAVESSVSCQIN---TCVIQSVRI-NTDQRGAPVRL-SMKAEA
TLN

PF02010 // ENSGT00700000104221_2_Domain_0 (304, 786)

ASVQLDCPAALAISQYWQVFSVPAVGD-APDWTQPLDVPQLEIRNSPMFIHIPSNSL
QWGVYVFNFTVSITTR-NPKMPEVKDSDAVYVWIVRSSLQAVM-LGDVNITANFTEQLIL
DGSTSSDPDA---DSPLQ--GLQFFWYCTTDPRNYRGDRIILGSKEVCHP-EQANLKWPW
ATGPVLTLLPETLKGDHVYFFRMVIQKDSRTAFSDKRVHVLQGPKTIAHITCIENCERTF
IVSDRFSLFLNCTNCAS-R-DFYTWSILSSSGGEMLFDWMGETVTGRNGAYLSIKAFAFQ
HFLEAEFSISLHLASWSGVTSVFRHSFIINHGPQIGECKINPAKGIALITKFVVQCSNFR
DKHVPLTYKIIV-SDL-HSVGEISSVKENTLGTILYLGPQSTSPPSFLPVGMVANQYALK
IYVQVYD-SLGAFSQVTLHATAQAPTDKNSSKTVLNQLLSFTMGPSS-LLSTLIQKQDFL
PAGYL

ENSGT00700000104221_2_Linker_0_1 (786, 1328)

LYIVASVLNNMRTELPLQNDRVSLRKHLIDQSFLLPVSTLVEIGQVVMTITKLTQ
KPSEFTWDAQKRATMRIWQANQALQEYQQKDKRFRSEQIEIMSTGILMSLSNILKMT---
--S--HQVVKDPFYVIESLSDTILANKVPGNKTTSMRTPNFNMYVKKVEKWGVT-QVFGN
EKHCR-NCFYPTLNASSVPGLSANAPISTMFCDFTNDPFPWLNDQE--NTSVQVFGFRMT
GVADNGSVVEITPDVAEVYLVRKNLTFAAFNLTVGPNGD---VDGSSKTTTGGFSFQVDS
RVLREVLVHIVTEVMVLFTVLVYTGSQITPTALLATFLVPHDIPPVASQ--SALFDPACR
V--KKARVVCLPVSLLQLIAQHS-HSPHCTVSIVLQAPRFVMKPNDKLVRISIFSIQCLD
MYGIQSEWREGYCVLGEKTSWHNVHCICK-NIVRARRQLGIVGLT--NIHLQTHYVMAKV
IVIPNPVDLRLNIIKSLHRNPVTFFTVLFIILLYVILAFWALYRDEIDQHLRGHVIVLPD
NDPYDNL

PF01477 // ENSGT00700000104221_2_Domain_1 (1328, 1442)

CYLVTIFTGSRWGSGTRADVFVQLRGTVSTSDVHCLSHPHFTTLYRGSINTFL
LTTKSDLGDIHSIR-VWHNNEGHSPSWYLSRIKVENLFSRHIWLFIC-QKWLSIDT---T
L

ENSGT00700000104221_2_Linker_1_2 (1442, 2158)

DRTFHVTHPDEPLTRKDFFFIDVSSNLQKNHMWFSIFASVVAKTFNRLQRLSCCLAMLL
SSLLCNIMFFNLNRQEQT-ESRERKYMRSMMIGIESVLITIPVQLLITFLFTYSQRK-PQ
ADLKEVSPQKHPLMS-EASEHWEEGLRKWHAYETAKAHPREVA------KPASK------
--GKPRLPKASPK---------------------------ATSKP-KRRHRKAQIKTPET
PRPNTNS---SNNIEDNQDVHS---E-EHP--------S-QQDLQQLKE-KPRIVLPWWC
VYVAWFLVFATSSISSFFIVFYGLTYGYDKSIEWLFASFCSFCQSVFLVQPSKIILLSGF
R---TNKLKYCKN--LLWSTNYKY--TEISLDGM---RMHPEEMQR--IHDQIV--RIRG
TRMYQPLTEDEIRIFKRKKRIKRRALLFLSYILTHFIFLALLLILIALLRHTDSFYYNQF
IRDRFSMD-LANVTKLEDIYRWLNSV--LLPLLHNDLNPTFLPESSSKILGLPLMRQVRA
KSSEKMCLPAEKFVQNSIRREIHCHPKYGIDPEDTKNYSGFWNEVDKQAIDES---TNGF
TYKPQGKQWLYYSYGLLHTYGSGGYALYFFPKQQQFNSTLRLKELQESNWLDEKTWAVVL
ELTTFNPDVNLFCSISVIFEVSQLGVVNTSISLHSFSLADFDRKTS---AEIYLYVA

PF00520 // ENSGT00700000104221_2_Domain_2 (2158, 2358)

ILI
FFLAYIVDEGYIIMQERASYVRSVYNLLNFALKCIFTVLIVLFLRKHFLATGIIQFYLSN
PEDFIPFHAVSQVDHIMRIILGFLLFLTILKTLRYSRFFYDVRLAQRAIQAALPGICHMA
FVVSVYFFVYMAFGYLVFGQHEWNYSNLVHSTQTVFSYCVSAFQNTEFSNNRILGVLFLS
SFMLVMICVLINLFQAVILSAYEEMKQPVYEEPSDEVEAMTYLCRKLRTMFSFLTSQSKA
KDEPEFFTDMLYGQPEKNSRRYLGLKTRNINGKKMVYLVV

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------ASCHTS---PCRILDASI-NRKAPG-LVRL-PRAEEV
TLQ

PF02010 // ENSGT00700000104221_2_Domain_0 (304, 787)

ATARWDCMQERGSQLAWRFYAVASEHD-VPDWSRPLRLPQPGPGGLGASTHIPKFSL
PCGLYLVNFTLTVLPP-DQDQAPLTKSDAIHVLVVMSPLKALL-LGNAKETVRFSEGLVL
NGTMSSDPDVGSLEDPLQ--GVQFSWYCTTNPGNYAGGHVAVTNKDVCRT-EQTTLDWPW
ASGPLLTLSPETLKGDRSYHFRMVIRKGDRAAFSDKTVHVLQGTMPTAHISCIENCDGFL
VISDRFSLSLNCTGCTS-R-DLYTWSILSPTGDEMMFDWVGQAVTRRDGAYLSIKAFAFT
DFLEDRFWVSLQVAGWSGVTLDLRYSFVINHGPEVGECKINPAKGIAILTKFVIKCSNFK
DKNIPLTYKVIV-ADL-DGTSRINSVTENTLGAILYLGTRSTTPPTFLPVGQLVNRYKLK
MYAQVYD-SLGSFTQVTLYATVGAPTDRNPSQMVLSQLRNFTEGPTS-LLSTLLQKQDWL
SAGYLL

ENSGT00700000104221_2_Linker_0_1 (787, 1329)

YIVASILNNLKVDLTLQKSKDSLREHLVNQSFELPVSTLDEICQVVTAITKLTQ
KASEFTPVAQKRATVRLWEANQALQRCQRKDKCVHSDRIETMSTGIFMSLSNILKLL---
--TP-YEVFEDPFYVVESLADTIAATKVPGSGITALRTSNFNMYVEKVEKWDVT-QAFRN
KKQCP-NCFHAALNASRDLGLPAQAPVSMMFCEFADDPFPWLSYLE--NTSAEVLGFRMT
GTTDNGSVIEITPDVADVFLTRKHLTFATFNVMVGPSNE---GARSSQMTTGGISFEVDS
RSVKEVLLHIVTQVTVLFKVSVYAGSQVTPTDLVATFLVPHDTPPTANQ--SSLFDPTCT
V--KEARVVCLSPSLLQVIAQRS-HSPKCHISVVLQAPRFVLQPTDQLVRIALFTVGCLD
MYGIQNDWQEGTCALGEKTTWKMVHCVCR-NVRRSRRQLSSIRLT--NLRLHTRYVTAKV
IVIPNPVDLQLKIIKNLHQNPVTLLAVLFIMFLYMALAFWALHRDEMDQFLWDHVVVLPD
NDPYDSMC

PF01477 // ENSGT00700000104221_2_Domain_1 (1329, 1436)

YLVTVFTGSRWGSGTRANVFVQLQGTENTSDVHCLSHPYFTTLYRGSINTFL
LTTKSDLGDIHSIR-VWHNNEGRAPSWYLSRIKVENLFSRQIWLFMC-RKWLSVD

ENSGT00700000104221_2_Linker_1_2 (1436, 1927)

T---T
LDVTFPATQPDQPLERKDFFLIDLSNRLEHNHMWFSIFSSVVAEPFNRLQRLSCCLAMLL
SSLVCNIMFFNLNKKEQS-GSREGRLMRSMMIGIESVIITIPVQLLITFFFTYSQKK-PR
VNPEEVAPQKHPLMS-EEDNPWKERLDKWYAYEIERDRAVEAEKP----ISPSR------
--AKPKAFGP-----------------------------------------TIKAKAPMT
SKSNM-------SFTNNQDASL-----RAP--------S-FRQDEHTER-KLPIVLPWWC
AYIAWFWVFAASAVSSFFIVFYGLTYGYDKSMEWLFASLCSFCQSVFLVQPCKIMLWSGA
R---TNQLKYCKN--LSWTSKYRY--SEIKLPEA---KMSPKEMAA--LHERIV--SIQR
SRMYQPLTEDEIRIFRRKKRIRRRALLFLSYLVTHFIFLALLLLLVALLRHSDTFYYNQS
IRHQFS

PF08016 // ENSGT00700000104221_2_Domain_2 (1927, 2365)

MD-LAAVTKLEDIYAWLHNV--FLPLLHNDLNPTFLLDTSSKILGLPLMRQVRA
KPSPKRCLPAETFVQNGNSGEIRCHLEYGVDPEDREDYASFWNKVGQWSTDKE---NDGF
IYKPPEKKWVYHSYGVLHTYGSGGYAFLFYPEQQTFNSTLRLQELQGESWLDEKTWAVIL
ELTTFNADASLICSISVVFEVSLSGPVNSSLSVYSFSLADFNRKTS---SEIYLYVAILI
FFFAYIIDEGYVIKQERASYIRSVYNLLNFALKCLFTMLIMVFLRKHFLATDMIRFHLSN
PEAFIPFHAVSQMDHTMRTILAFLLFLTILKTLRYSRFFYDVRLAQSAIQAALPGIFHMA
LVVSVYFFVYVAFGYLVFGQHEWNYSSMIHATQTVFSYCVSAFQNTEFSTNRVFGVLFLS
SFMLVMICILINLFQAVILSAYEEMKQPVFEEPSEEVEAMAYLCGKLRVVFGFLTFRSKT
TDHPDFCSSMLYGQPEKNSRQYLGLKTRNINGKKMVYLVL

------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------WRTPPHRA-
LGRP-EWTFWLLPVGTANMRRPRR-A--A--------SDLPAHDGLGPYMGFVAQTKCPT
DGPT-PVVLEAVNSDGPQAIDSSVSCQVSAQLPCEVTMVKI-NRNKDGVPLVV-TRKLGD

PF02010 // ENSGT00700000104221_2_Domain_0 (301, 860)

TLNATFQFNCEKASLIVPEWHAFSVPSVND-VPDWNAPLDTPHIQLGRTPAFLHIAPNSF
SWGVYVFRFTISLFRE-KPKTLLATGSDFIYVTILRSDLKAVV-PGGPNITINFTDRLVL
DGTNSSDPDS---ENPSE--GLLFSWYCTTDPKNYQGDKITVMSNSVCLP-KQTDLNWKG
ASGPVLTLSPGTLKGGGVYFFRMVIQKGGRTAYIDKRVHVLKGRTPKANISCIENCDAVL
VISYGFSLFLSCTNCSASQ-DVYKWSILSSSGDEITFDWVKHTTTGRNGAYLSIKAFAFK
DFPEAEFWISAHLAAWSGENLDLRHPFIINYVPEIGECTINPAKGVALFTRFVIRCNHFK
DKNIPLTYKMIV-SDL-YGFGQISSVKENTLGAILYLGNESTSPPSFLPVGVLANRYAMK
IYVQVYD-SLGAFSQVTLYATVRAPTDRVSEKDVLDRLFNFTVGPNS-SLSTMLANQEFL
PAGYLMYIAASVLNNMKPEFTLQADKARLREYLVNQTFILPNSTLVEISQVVMSVTKLTQ
TTSGFTRMAQKLATVRVWQ

ENSGT00700000104221_2_Linker_0_1 (860, 1327)

ANRALQQSRQKDSDFHSEQIEIVSTGILTSLSNIFKLT---
--VS-YEVVDEPFYVLELLADTILEGKVPGNETTAMTASSFNVYVRKAEKWDVT-DVFSN
EKSGR-SYFRPVLNVSSIPSLPANAPISTMFCEFADDPFPWMNAQE--SCSADVVGFRMT
GTTPNGDAIEIMPDIAEAYIARRNLSSATFNLTVGPENGPEGGDESLQSTTGQFRFEVDS
GVMKELLVHIVTEVTVVFTVLVYAGSEITPSALVATFLVPHDIPPVATQ--SVLFDSACS
V--KEARVVCLPASLLQVIAQRS-GSAECTLIVVLRAPRFVMRASEKLVRIALFSVHCLD
MYGIQSDWREDTCVLGEKTTWRRLHCICQ-NTRRARRQLHLIKQA--NTHLQTHFLTAKV
IVVPNAVDLRLEVIKNITHNPVTLFAVLFIMLTYIILAFWALLRDEMDQYLRQHVIILLD
NDPYDK

PF01477 // ENSGT00700000104221_2_Domain_1 (1327, 1445)

VCYLITIFTGVRCGAGTKADVFIQLKGTGGESDVHCLSHPHFTTLYRGGINTFL
LTTKSDLGDIHSIR-VWHNNEGKAPRWYLSRIKVENLFSRHIWLFLC-RKWLSVDT---S
LDRT

ENSGT00700000104221_2_Linker_1_2 (1445, 1926)

FHVTDPGQPINRKDYFLIDSTYKLGKDHMWFSIFSGISARPFSRLQRLSCCLAMLM
ASLLCNIMFFNLDRPEET-ESEEGRFIRSMMIGLESVLITIPVHLLIAFLFTYSQSE-PR
VSLEDVSPRKRSLVS--DSGHWEEFLKKWHSHETLPAPTKEAS------KLPPG------
--KSPRLHKASAK---------------------------APSMA-QHMHKKGESKVSHT
QEKNI--NVSNANTGNNQDVAS---GEPP---------T-PVGPVGLKE-KGRIVLPSFC
VYIAWFLVFVTSSISSFLIVFYGLTYGYEKSMEWLFASFCSFCLSIFLVQPSKIILLSGL
R---TSRPKYCKN--LSWAGRHCY--IEIKLR-S---TLSPEEMEK--RHEQIM--QLRR
SRMYQPLTEDEIRIFKRKGRIKRRAFLFLSYILTHFIFLALLWSLVALLLHRDSFHYNQF
IRDQF

PF08016 // ENSGT00700000104221_2_Domain_2 (1926, 2365)

SVD-LGLVTKLADIYRWLDSV--LVPLLHNDPNPTFLPDSSSKILGLPLLRQVRA
KPGDKLCLPANSFAQTSMEGEIRCHPNYGTDPEDTRNYSSLWNKVAKRAEDTN---TNGF
TYRPPEKRWGYFSHGLLHTYGSGGYAFYFFPEQQQFNSTVRLRELQSSAWLDEKTWAVIL
ELTTFNPDVSLFCSVSVIFEASQLGVVNASVSAHSFSVVDFNRETS---ADIYLYVAILI
FFLAYVVDEGYVIMQERASYVRSVYNLLNLALKCIFTALIVLFFRKHFLATGIIRFYLSN
PADFIPFHAVSQVDHVMRIVLGSLLFLTILKTLRYSRFFYDVRLAQRAIQAALPGICHMA
LLVSVYFFVYMAFGYLVFGQHEWNYSNLIHATQTIFSYCVSAFQNTEFSHNRLLGVLFLS
SFMLVMICILINLFQAVILSAYEEMKQPVYEEPSDEAEAMTYLCRKLRAMFRFLTLQPRD
KDEPEFFVNMLYGQPEKNSRRYLGLKTRNINGKKMVYLVV

MGPGSTLL-LP---------GLFLVLGCFSSPSRLRGSPAWTSGVPRVTPGL--------
------------------------------------------------------------
--------------------------------------------------RLGISPVHPG
QS----------------------------------------------------------
EGSKAPSL-HAAP------------PHQRTVSPCHHRQVKI-IQRK-----------AEV
------------------------------------------QLQAGVHWSALH

PF02010 // ENSGT00700000104221_2_Domain_0 (355, 788)

SPGASL
NPGRKLLHFTEAITTW-DPNALLVKDSDPVSVWPISSPLRAVL-LGDASQMVHFTDELIL
NGTVSFNPDA---DNPVE--GLHFSWYCTTNAGNYIGDQVTETDQEVCHP-DQANLHWAW
AFGQVLMLSPETLKGDRVYYFRMVICKGHKAAFFDKRVHVLQGPTPTAHISCNENCDPIL
DVSRRISLFLNCTSCGR-R-DVYTWSIFSPLGEEVSFDWSRQTVTGRNAAYLSVKAFAFQ
SFLEAKFWVSVYLESWSGTTLEFRHSFIINHSPQIGECQVNPAKGIAMFTQFVIKCSHFK
DQHVPLAYKITV-SDL-GSVGDVSLVKENTLGTILYWGTQATAPPSFLPVGSSANHYALK
ILVQVYD-SLGACSPVTFSVTVCPPTDRSSAKTVLWHLLNFTLGPTS-LLSTLLHGQDWL
LASRLMN

ENSGT00700000104221_2_Linker_0_1 (788, 1329)

VVASVLNSMETAQSLREHKAHLREHLLNQSCTLPLRTVEEVGQAVTAITELTR
EASEVTQVAQKYATVGIRQANQAPQTYEREDEHFSSEQIEMVSAGILMSLSNILKLA---
--TP-HEVFEDAFYVMESLSDTVLAHKVPGSEATVLRAPGFGMYVEKVAKWDAA-QAFRK
EKHGQ-NWFHVILNTSRVPGLAVNAPVSVMFCEFTDDAFPWLNYPE--SISTEVGGFRMT
GATGKGSMIEVIPDTVEVYLTRKNLTSATFNLTVGPDSE---ATGSSGTMAGAFSFEVDS
RGVREVLVHIVTEVTGLLKVLVYVGRHVAPTHLVATFLVPHDMPPVVIQ--SVLFDPACR
V--RVARVVCLPPSLLQVMTRHS-RSPKCDISVVLQAPHFVLEPSHKLVRISVFGASCLD
MHRIRGQWREDACTLGEKTTWNKVHCTCR-YMTRARRQLRTP--T--HVPLRTRYVMGKV
ITIPNSVDLQLNVTQDCQYNPVTLLTVLFIMVIYTILAFWALHRNEMDQFLWDYVVVLPN
NDPYDNTC

PF01477 // ENSGT00700000104221_2_Domain_1 (1329, 1446)

YLVTIFTGSCCGAGTRASVVVQLRGTESTSDVHCVSHLHFRTLFRGSISALL
LTTKSDLGDIHSIR-VWHNNEGKAPNWYLSRIKVENLFSRHIWLFMC-RKWLSVDT---T
LERMF

ENSGT00700000104221_2_Linker_1_2 (1446, 1929)

HVTYPEEPVRRMDFFLIDLTYKLRTHRMWFSVFADFVAKPFSRLQRLSCCLATLL
SCLLCNTLFFNLNSQEKA-ASREGRYIRLMTIGIQSVLITIPVPMLITFFFTHSQKK-SQ
VELDEVVPQKHPLTL-AGSEGWEERLCKWEVCEADKGCSREASKP------TVK------
--VLSGQPKASLQ-----------------------------------------------
V------TAETAETNTNVNVPS---GEPS---------S-QGDPKHCKT-QPWITLPRWC
VYVAWLLVLTTCTVSSVFIIFYGLTYSYDKSVEWLLASFCSFCQSVFLVQPLEIILWSGI
R---TNKPKYCRN--LAWSTKYQS--IEIKLWGM---RMHPDERQQ--LQEHLT--CLRG
SKMYQPLMEDEIRIFRRRKRVKRRAVLFLSYIVMHCIFLALLLLLIVLLHHTDSFYYYQF
IQDCFSGD

PF08016 // ENSGT00700000104221_2_Domain_2 (1929, 2365)

-LPAVTNLEDIYKWLNRV--LLPLLHNDRNLTFLPDSSSKILGLPLKRQVRA
KPGGKMCPPAKSFVQDSMAGEIHCHPKYGTDAEDTTNYSRFWGEVDKQAMSRN---IDGF
TYKPQGKRWVYYSYGPLHTYGSGGYVFYFFAEQQQLNSTLRLRELQESNWLDEKTWAVIL
ELTTFNPDASLFCSISIVFEVSQLGVVNASISTHSFSLTELHSESL---AEIYLYVAILI
FFLAYIVDEGYVITQEGASYVKSMYNLLNFTLKCIFTALVMLFFRKYFLAAGMIQFYLSN
PHDFIPFQAVSQVDQTMRIILAFLLFLTILKTPRYSRFFCDVRLAQRVIQAALPGICHMA
IVVSVYFFVYMAFGYLVFGQHEWNYSNLIHATQTIFSYCVSAFQNTKFSSNKVLGVLFLS
SFLLVMVFLLINLFQAMILSAYEDMKQPVYEEPSEEVEVMSYLYHKLRSVFSFLAPDPRA
RDEPEFFIDMLYGQPEKKSCRHLGLKTQNINGKKIIYLVV

MRPGPALLLL-GL-G------LSLSVGRLPLPPAPRGAQAAVSGA----PGGLLRGAPGL
GVRGG-------------------------------------------------------
------------------------------------------------------------
------------LLGPGAARPASP-AAR--------VSPRSAAPGPRPQQGFVARTECPT
DGPA-RVMLQAVNSSSHRAVESSVSCQIN---ACVIQRVRI-NTDQKGAPVRL-SMKAEA
TIN

PF02010 // ENSGT00700000104221_2_Domain_0 (304, 786)

ASVQLDCPAARAIAQYWQVFSVPAVGQ-APDWTQPLDLPQLEIRNSPLFIHIPSNSL
QWGVYVFNFTVSITTG-NPKMPEVEDSDAVYVWIVRSSLQAVM-LGDANITANFTEQLIL
DGSTSSDPDA---DSPLQ--GLQFFWYCTTDPRNYRGDRIILGSKEVCHP-EQANLKWPW
ASGPVLTLLPETLKGDHVYFFRMVIRKDSRTAFSDKRVHVLQGPKATAHITCIENCERNF
IVSDRFSLFLNCTNCAS-R-DFYKWSILSSSGGEMLFDWMGETVTGRNGAYLSIKAFAFR
HFLEAEFSISLYLACWSGVTSVFRHSFIINHGPQIGECKINPAKGIALITKFVVQCSNFR
DKHVPLTYKIIV-SDL-HSVGEISSVKENTLGTILYLGPQSTVPPSFLPVGTLASQYGLK
IYAQVYD-SLGAFSQVTLHATAQAPTDKNSSKTVLNQLLSFTVGPSS-LLSTLIQKQDFL
PAGYL

ENSGT00700000104221_2_Linker_0_1 (786, 1329)

LYIVASVLNNMKTELPLQDDRVNLRKHLIDQSFLLPVSTLVEIGQVVMTITKLTQ
KPSEFTWDAQKRATMRVWQANQALQEYQQKDKHFRSEQIEIVSTGILMSLSNILKMT---
--SP-HQVVKDPFYVIESLSDTILANKVPGNKTTSMRTPNFNMYVKKVEKWGIN-QLFRN
EKHCR-NCFYPTLNVSSVPGLSANGPISTMFCDFTNDTFPWLNDQE--NTSVEVSGFRMT
GVADNGSVLEITPDVAEVYLVRKNLTFAAFNLTVGPSRE---VDGSLKKTTGGFSFQVDS
TVLREVLVHIVTEVMVLFTVLVYTGSQITPTALVATFLVPHDIPPVASQ--SALFDPACT
V--KKARVVCLPVSLLQLIAQHS-HSPHCTVSIVLQAPRFVMKLNDKLVRISIFSVQCLD
MYGIQSEWREGYCILGEKTSWHEVHCICK-KVVRARRQLGTIGLT--GIHLHTHYVMAKV
IVIPNPVDLRLNIIKSLHQNPVTLFTVLFIILLYVGLAFWALYRDEMDQHLRGHVIVLPD
NDPYDNLC

PF01477 // ENSGT00700000104221_2_Domain_1 (1329, 1446)

YLVTIFTGSRWGSGTRANVFVQLRGTVSASDVHCLSHPHFTTLYRGSINTFL
LTTKSDLGDIHSIR-VWHNNEGRSPSWYLSRIKVENLFSRHIWLFIC-QKWLSVDT---T
LDRTF

ENSGT00700000104221_2_Linker_1_2 (1446, 1927)

HVTHPDEPLTRKAFFFIDVSSNLQKNHMWFSIFASVVAKTFNRLQRLSCCLAMLL
SSLLCNIMFFNLNRQEET-ESRERKYMRSMMIGIESVLITIPVQLLITFLFTCSQRK-PQ
ADLKEVSPQKHPLMS-EASEHWEEYLRKWHAYETAKVHPREAA------KPASK------
--GKPRLPKASPK---------------------------ATSKP-KHRHRKAQIKTPET
LGPNTNS---NNNIEDDQDVHS---E-QHP--------S-QKDLQQLKK-KPRIVLPWWC
VYVAWFLVFATSSISSFFIVFYGLTYGYDKSIEWLFASFCSFCQSVLLVQPSKIILLSGF
R---TNKPKYCKN--LSWSTKYKY--TEIRLDEM---RMHPEEMQR--IHDQIV--RIRG
TRMYQPLTEDEIRIFKRKKRIKRRALLFLSYFLTHFIFLVLLLILIVLLRHTDCFYYNQF
IRDRFS

PF08016 // ENSGT00700000104221_2_Domain_2 (1927, 2365)

MD-LATVTKLEDIYRWLNSV--LLPLLHNDLNPTFLPESSSKILGLPLMRQVRA
KSSDKMCLPAEKFVQNSIRREIHCHPKYGIDPEDTKNYSGFWNEFDKQAIDES---TNGF
TYKPQGKQWLYYSYGLLHTYGSGGYALYFFPEQQRFNSTLRLKELQESNWLDEKTWAVVL
ELTTFNPDINLFCSISVIFEVSQLGVVNTSISLHSFSLADFDRKAS---AEIYLYVAILI
FFLAYIVDEGCIIMQERASYVRSVYNLLNFALKCIFTVLIVLFLRKHFLATGIIRFYLSN
PEDFIPFHAVSQVDHIMRIILGFLLFLTILKTLRYSRFFYDVRLAQRAIQAALPGICHVA
FVVSVYFFVYMAFGYLVFGQHEWNYSNLIHSTQTVFSYCVSAFQNTEFSNNRILGVLFLS
SFMLVMICVLINLFQAVILSAYEEMKQPVYEEPSDEVEAMTYLCRKLRTMFSFLTLQSKA
KDEPEFFIDMLYGQPEKNSHRYLGLKTRNINGKKTVYLVV

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------MTCKLDPVRI-NRNDD-KPVRL-TRDMGD
TFN

PF02010 // ENSGT00700000104221_2_Domain_0 (304, 788)

ATVILFCPVQQYYLRIWYIYPVPYVGA-VPDWTKPMQNPPVKADRTSTVLTIFPYSF
TWGVYLFNFSVVVRTW-DPRVPGQEDSDSIYVVIFRRPLNAVI-SGPSNITSNFTDGVTL
NGNTSSDPEE---TDPLEKERLKFLWYCTTNPRDYDGQKITVISKEVCLP-EQVDLKWTW
ASGPILTLSPETLQGGRVYFFRLVIQKTGRSAFADATLRVLQGN-PVASISCIENCDQVL
VLSERFSLSLDCTGCTAGR-DVYRWSILTSSGQEVPFDWTGQTSTGRHGAYVSIKAFAFW
SFKEDKFWISLNAATWSGVTLVLRYPFIIHHVPITIDCTIVPEKGISFITQFVVICTHFK
HKNIVLTYKIIV-PEV-HGFGEISSVKENNFGSILYLGKNSTSPPSFLPVGVLDSHYALK
IIAQAYNTSLGAFSQVNLYATVRPPTDVKSSTTVLEELSNFTTGPNS-SLSTLLQQQDFL
NASYLIY

ENSGT00700000104221_2_Linker_0_1 (788, 1329)

VVASVMNSMKTDASLQADKVKLREHLFNQTLILPINTLANISQVVMAVTKLTE
KTSEISAFSQKLATVRTWQASQALQDSHQRDKSISSEQIESVCTGILTTLSNILKLL---
--VH-YEVFEEPFHVVESLADTVLAVKVPENKTTALRTSNFKMHVKKTEKWNVT-KFFST
QKHCQ-NCFYPTLNVNSVASLPANAPISTMFCEFADDPFPWLNHGE--NILTQVVGFRMT
GVEVTGDVIEMPPDAVEVYLIRKNLSFGTFNLTVGPSSEPYAVDESSAKTTGAFSFVVDS
AAGRDVLIHILTDVSVLFTVSVYAGREITPNSFMTSYLVPHKIPPIANE--SDLFDPECP
V--KETRVVCLPAALVQVIAQRT-DSSECTVAVVLQAPRFVLNPNNKLVRISVFSTECLD
MFGIQSDWREDTCVVGEKTTWQRVHCMCK-NPRRAKRQLDIIKQA--NLRLRTHYLTAKV
IVVPNPVDLRVEAVKNVTQNPVTLFTVLLIMLLYLILAFWALHRDETDQYLREHVIVLLD
NDPYDNVC

PF01477 // ENSGT00700000104221_2_Domain_1 (1329, 1443)

YLVTVFTGSRCGSGTRANVFIQLHGTEGSSDVHCLSHPQFTTLYRGSICTFL
LATQKDLGDIHSLR-VWHNNEGRSPEWYLSRIKVENLFTRHIWLFMC-REWLSIDT---S
LD

ENSGT00700000104221_2_Linker_1_2 (1443, 1927)

RTFQVTPPDKPLKKMDFFLIDFSYKLGRSHLWFSVFSGVISTPFNRLQRLSCCLAMLL
STLLCNIMFFSLEKEIEA-EPQEQKYIRPMVIGLESAFITLPVQLVIKSLFIYSQRR-PR
VTLSEVTPRKHPLQP-PASEHWEERLGNWHAYETAKASSQEPMSKRHRAKPKAS--VNVT
SKRQPPAKQAESQGFPIKSKVSRTQSKVSRAQSKVSRAQSKVSRA-QSKVTQAQSKFSHI
QGRN--INTNSRNIEDNTNVSD-----EHP--------P-QPGSRALKE-KTRIVLPPWC
VCVAWLLVFLTCAVSSFFIIFYGLTYGLEKSTAWLFASFCAFTQSVFLVQPSKIILVSGY
R---TRRAKYCKN--VSWIGNSRF--TEIKLHNI---RKDPEEMDR--RHRYVM--ELRN
SRMYQPLTQDEITIFKRKKRIKRRAFLFLSYILTHFIFLALLLSLVAVLRPTDSFYYNQF
IRDQFS

PF08016 // ENSGT00700000104221_2_Domain_2 (1927, 2365)

VD-LAGVARLEDIYQWLNRV--LLPLLHNDPNPTFFPDSSSKILGLPLMRQVRA
QPGEITCMPAKKFVEGSLKGEIRCHPEYGIDPEDTKNYSGSWNRVSKRDTDQT---AGGF
TYRLPEKRWAYSSYGLLHTYGSGGYAFYFFPAEQQFNSTLRLSELQKGHWLDEKTWSVIV
ELTTFNPDISLLCSVSVLFEVSQLGVVNTSLHAHSFSLAHFNRKYSADSAENYLYLAIFI
FFLAYTVDEVYVITQERTAYVQSVYNLLNFALKCIFTLWIVLFVRKHFLAIGVVRAYLSN
PEDFIPFHAVAQVDYTMRVILGFLVFLTILKTLRYSRVFYDVRLAQRAIQIALPGICHMA
LVVSVYFFVFMAFGYLVFGQHEWNYSDMIHATQTIFSYCVSAFENTEFFNNRVLGVLFLS
SFLLVMICILINLFQAVILSAYEEMKQPVYEEPSEEAEAMTYLCHRVRSAFCCLCFKPRR
KTSPGSSSTWCTGSRRRRAAATWG----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MRKDRA-------------
---EMVISFL

PF01477 // ENSGT00700000104221_2_Domain_1 (1331, 1433)

VTLYTGSRWGAGTSADVFLQLIGQNGTSDIHCLRHPELPAFRQGSTDCFL
LTAKEDLGDIRAFR-VWHNNRGPSPSWFLSRAKVEHVSTQKTWFFMC-RKWLALDKGDRL
LER---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------

MRPGPALLLLSLLLLLLLLQGPGLASGRRPPPRAARGGRAPIADAPRSPAEDLRGPAPAS
----------ARRPPPAARAPVPVRGEAAAPRRVQAAQGPGVRGGGGGTGGGRAQLSLR-
---------------------PRAAL-----GGGLIRSGGRGRPALRRLARLPRS--LPG
LEPT----SRPGPLGSV----------------SAAAASHVSPSSPR----PGGRARCPT
DGPT-PVAFEAVHPNGSQAVESSVSYE----YPCVLEPVRI-HRNETG-PLHW-SRSREL
TVNS

PF02010 // ENSGT00700000104221_2_Domain_0 (305, 788)

TVQYRCPNLQFINYHWRLFPVNSVSD-VPNWSSPLRNPPFRAAMEPNVIHIRRNSL
SWGVYVLNISVVIYRR-HPRIPMLRDSDSIYLVIGRAPLKAVI-PGPANISINFTEGLTL
NGSASSDPDA---QNPSE--GLQFFWYCTTDPRNYQGETVRVNSRDVCLP-EQADLRWPG
ASGPVLTLPPGTLKGAGAYFFRMVIQKNNRTAFADKTVHVLREPTLVANISCIENCDAVL
VTPDRFSLSLECTHCTAGR-DVYRWSILSSSGDEIPFDWTRQTATGRNGAHLSIKAFAFQ
RFPEGNYSVSLHLTTWSGWTLDLRHPFIIRRISEIRECKISPAEGIALWTKFVIRCNNT-
EINVPLTYKIIV-SDV-HGFGEISSLKENTFGAILYLGEEPTSPPSFLPVGVVASHYAVK
LYVQAYNNALGAFSQVILYATVQAPTDRNSSGTVLGQLFNFTEGPNS-SLATLLQQREFL
PAGYLIY

ENSGT00700000104221_2_Linker_0_1 (788, 1329)

VVASVLNSLKPEPPLEANKTRLQEYLFNQTFALPITTLVEISQVVMCVTKLTQ
KTSEFTPMARKLAMVRVWQASRALQQCHARDRRVSSEQVETVSTGILTSLSNVLRQT---
--TR-HQVEEEPFHVVEALADTVLAVKV---------TSNFNMYLKKTEKWNVT-KFFSG
QRHCRSNCFYPTLDVNSAPSLPARAPISTMFCEFADDPFPWLKYQA--SSLTEVVGFRLT
GAEASGAVTDITPDVAEVHLLRRNLTFGAFALMVGSSQEPGTGDAASRKTTGAFCFPVDS
QTRKEVLVHIVTEVTLLLTVLVYAGRQMAPDALVATFLVPHELPPIANH--SDLFDSACT
V--RTARVLCLSPSLLSVLARRAGDSPECTVTMVLEAPRFVLKPTDKLVSIALFSIQCLD
MYGVQSDWREDTCDLGEKSSWDKIHCICR-TPRRAKRQLGLTDLS--SLPMHTYYVAARV
IVVPNPVDLRLDTIRKVMWNPVTLLTVLFITLLYIILAFWALHRDEMDELLREHVVVLPD
NDPYDDVC

PF01477 // ENSGT00700000104221_2_Domain_1 (1329, 1443)

YLVTVFTGSRCGSGTRADVFIQLQGTEGSSDVHCLSHPKFTTLYRGSISTFL
LTTKSDLGDIQAIR-VWHNNEGRSPSWYLSRVKVENLFRRRIWLFLC-REWLSVDT---S
LD

ENSGT00700000104221_2_Linker_1_2 (1443, 1933)

RTFPVTLPDTPLARRDFFLIDLSYKLGKSHIWFSVFSGVISKPFNRLQRLSCCLAMLL
SSLLCNIMFFNVDEEKDAPGAPGVRLIRSMMIGLESALITVPVQVLITFLFFYSQRR-PQ
VSLEEVSPQEHVFTS--TSGHWEERLKKWHAQEVDKERVRAPRKHRLKR-----------
--KTRGLRKAPTK---------------------------ATSKT-RSKAKPAESQAPRA
QEKNRNT--NNPNAGDDQTAAS---G-ESL--------E-LPGIEPFKE-KPRIVLPWWC
VYVAWFLVFATSSISSFFIVFYGLTYGFSKSIDWLFASICAFILSVFVVQPSKIILLTGY
Q---TGKPKYSKN--ISWATNYHY--SEIKLSDL---RKNPEEMQR--LQEYNA--QLRS
SRMYQPLTEDEIGLFKRKRRVKRRAFLFLGYILTHFVFLALLLVLVALLRHRDSFYYNQF
IQDQFSVD-LAT

PF08016 // ENSGT00700000104221_2_Domain_2 (1933, 2365)

VTK----------V--LLPLLHNDARPRFLPDSSSQILGLPLMRQVRA
QPGNKTCPPAKNFMQNSLHKEIHCHPQYGTDPEDTRSYAGSWSRVSKRAVAEN---AHGF
TYKPPEKRWRYASHGLLHTYGSGGYAFYFFPKEQPSNSSLRLSELQGNHWLDEKTWAVLV
ELTTYNADVHLFCSVLVAFEVSQLGVVNTSLSARSFSLANLDRGAS---AEVYLYVAVLI
FFAAYVLDEAYVLAQEGTAYVRSLYNLLNFAFKCSFALLIVLFLRKHFLAAGLTRSYLSR
PEDFVPFHAVSQVDHTLKVVLGVLIFLTILKTLRYSRLFYDVRLAQRAIQIALPGICHMA
LVVSVYFFVFMAFGYLVFGQHEWNYSDMTHATQTVFSYCVSAFQNTEFAHSRAMGVLFLL
SFTLVMVCVLINLFQAVILSAYEEMKQPVYEEPSEEAEAMAYLCYRLRSTFGLRSAPAKP
RQESEFFVDMVYGQPERNSRRYLGLKTRNINGKKMVYLVV

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------GLPESSPVSVMFCMFAADPFPWLAEPA--LSAVRVAGFRVT
GTGQNGDTVDVVPDVTDTFLLRTNLSDGLFPLTVGPEDQSEETGEPGRVTSGAFSFELGS
-TAQEVLVYILTEVTVLFTASLYAGRTVSEAALVATFLVPPDGPPVANQ--SDHFDPACA
V--TSVHVLCLSPSLLQLVAERS-HRPGW---VVLRAPRFVTSPTSRLVNVSVLRLQCLD
MAGDYGEWREHTCALGPHTTWARVHCVCAAHAGRARRQLGFLRDT--GEQLKTHFLSSRV
LVAPNYVDLRLEVIKTIPQNPVTLVTVVLIMVLYVAFAFWALHRDETDQFLRDHVIVLPD
NDPYDN

PF01477 // ENSGT00700000104221_2_Domain_1 (1327, 1407)

FCYLLTVFTGSRWGAGTRADVFVQLRGSEAASDVHCLSHPQVRALYRGSVNTFL
LTTRADLGDLQSLR-VWQNN-GRAPG

ENSGT00700000104221_2_Linker_1_2 (1407, 1926)

WXXXXXXXXXXXXXXXXXXXXXXXXXXXXX----
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXX-XXXXXX-
--XXXXXXXXXXXXXXXX---XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--X
XXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX------
--XXXXXXXXXXX---------------------------XXXXX-XXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXX---X-XX---------X-XXXXXXXXX-XXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXLLASFCSFCQSVLLVQPLKIILISGY
R---ANQPKYAKN--LSWTSSYQY--TQIHLA-P---RLSPEETEA--LHRDIA--ALRR
SRMYQPLTEDEVRIFRRKQRVRRRALLFLGSVLTHVLFLGLLLALAAALDHAETFEHNRF
LLDRF

PF08016 // ENSGT00700000104221_2_Domain_2 (1926, 2365)

SMG-LGGVTRLHDVYQWLGRV--PVPLFHNAQQPTFLPESSSKILGLPQVRQVRA
EPGEKPCPPAQKLGPSQSRGRIRCHPEYGVDREDTRNYSRAWGEAY----GKK---AEGF
LYKPPEARTAYTSFGALDAYGSGGYVFYFYPEEQHFNSTLRLAALQQGRWLDAHTWAVIL
ELTTLSPDAGLLCSLSVLFEVSQEGAVSASLALHAFALAGLGRESA---AEVCLYSALLL
FFAAYVLDEAYAVGQEGAAYVRSVYNWLNLALKGLFAVGIVLFVWKHVLATRLTHACVSR
PAAFLPFHAVAQLDHAMRVILGLLIFLSVLKSLRYTRAFYDVRLAQGAVQAAAPAIGHVA
LMVAVCFFAYVVLGYLVFGQHEWHYSSPAAAVQTILSYCVSAFRDTEFLGERALGLLFLA
SFLLVVISVLISLLRAVLLSAYAGMRQPVYEEPSDEAEAVTYLCRKLRAA-GLRAVPAGA
EPEPECLVGMVYGQPLRRGRQYLGLKTRNISGRRMVYLVV

MRPGPTLLL-L---------GL--GLSCFPLLAWPSGVSRD-------------------
------------------------------------------------------------
----------------------------------------------TLGLRLRIPPAHPG
LRPLVAREDNVLPGNPGSEAPPRR-PRPA-------------HSAP-----HPVASGCPP
GGPSAPSD-------GRA---AVGPCQPD---PCGLQQVKM-VCQR---------RKAEA
PLGD------------------------SV-QTGWPRPRRA

PF02010 // ENSGT00700000104221_2_Domain_0 (342, 786)

LQPQAQARPSTHRDQGASL
AMGLNVFKFTMAISTLQAPKALLVRDSDSISIGTGWRPPGPP--HGDASLTVNFTDELIL
DGASSLDPDA---HGPVE--GLHFSWYCTINAGNYLGDQVRRTEQEVCHP-DQASLHWPW
ASGPLLTLPPGTLRGDHVYYFRMVIRKGHKAVSSDKRVRVLRGPAPTAHISCIENCGRVL
AVSQRFFLFLNCTSCGP-W-DIYTWSIRSASGEELPFDWTQQTTTGRNSAHLSVKAFAFQ
RFLEATFWVSVFLESWSGVTLEFQHSFVINHGPQGGQCHINPGKGIAMLTEFVVRCSHFK
DKHVPLTYKITV-SDS-DSAGDTSLVKEDTPGTILYRGPQAATPPAFLPVGSSARHYALQ
ISAQVCD-SLGAFSQVRLSVAVWPPTDSSRAKGAWQRLHSFPRGPAS-LLTTLLRRHDCS
FAGCL

ENSGT00700000104221_2_Linker_0_1 (786, 1329)

MSVVASVSKSLGAEQSLSEDRAHLQGRLSSRSFTLLLRTLQEVGQAVRAVAGTTQ
EASEVTRVAQKRATERLWQASRALQTYQREHEHVSSGQIETVSAGILMSLANMLTLA---
--TP-HKVFEDPFYVVESLSDAVFAHQVPGSAATVLRAPGLNMYVETVAKWDVA-WAFRK
DKQGR-NWFRAVLNASRVPGLATNAPVSVVLCEFTHDPFPWISYPE--SISTEVEGFRIT
GVTDNGSMVEITPDIVEVYLTRKNLTHATFNLTVGLDCK---VPESSKMTTGGFSFEVDS
RGVGEVLVHIVLEGTVLLTVLVYVGRHVTPTDLMATFLVPHDSPPLAIH--RGLFDPACA
V--RRARVVCLPLSLLQVMAQHS-HSPKYNISVVLQAPSFVLEPPNKLVRIYVFSARCVA
MSRTQTEWREDACMLGEKTTWDTVHCTCR-DRGRIRRQLRAP--I--HVPLHMRYVMAKV
TSIPNPVDLPLMVTPDGQYNPVTLLAVLSIMLVYTGLASWALHRSKVDQFLRDHVVILPD
NDPYDNVC

PF01477 // ENSGT00700000104221_2_Domain_1 (1329, 1445)

YLVTVFTGSRCGAGTTADVFVQLRGTEGASHAHCLSHPHVRKLLRGSISAFL
LTTKSDLGDIRSIR-VWHNNQGKAPSWHLSRIKVENLFSGHVWLFMC-QKWLSVDT---T
LERT

ENSGT00700000104221_2_Linker_1_2 (1445, 1927)

FRALRPDEPVKRKDFFLIDLTYKLRTHHVWFSVFTGFVAKPFSRLQRLSCCLAMLL
SSLFCNSVFFNLNRHRQA-ASREGRYMTSMTIGIESVFITILVQMLITFFFTHSQRK-PR
ADLHVVVPQRQPLTL-EGSGCWEDRLCRWYAAKASLQVASE-------------------
--------------------------------------------T-EHQHEKAEASADVH
----------NRNTDTPC-------GEPS---------S-QQDASRHQT-QSWLALPRWC
VYVAWFLVLTTCTVSSFFIIFYGLTYSYDKSVEWLFASFCSFCQSVFLVQPLKLVLWSGI
R---TMKPTYCKD--LAWSTEHQH--VEIKLQGT---RVRPGDVQK--LQERTA--HLRG
SRVYQPLTEDEVQIFRRRKRIRRRAVLFLSYIVTHGIFLALLLLLVVLLRHTDSFYYNQF
ILDCFS

PF08016 // ENSGT00700000104221_2_Domain_2 (1927, 2365)

AD-LAAVTKPEDIYRWLHLA--LLPLLHNYRAPTFLPDSSSKILGLPRMRQVRA
KPTMKTCPLAKSFRQNSMAGEIHCHPEYGTDAEDTRNYSRFWSEVNKQATDRN---TDGF
TYKPQGKTWVYYSYGVLNTYGSGGYVFYFFPEQQQLNSTLRLRELQAGNWLDDKTWAVIL
ELTTFNPDISLFCSVSVLFEVSQLGVVNASISTHSFSLAELHSKSS---AEIYLYAAVLI
FFLAYVVDEGYVITQERASYVKSIYNLLNFALKCIFTVLVILFFRKYFLATAMIQFYLSS
PHDFIPFHAVSQVDHAMRIILAFLLFLTILKTLRYSRFFYDVRLAQRVIQAALPGICHMA
VVVSMYFFVYMAFGYLVFGQHEWNYSNLIHAAQTIFSYCVSAFQNTKFSNNRALGGLFLS
SFLLVMVCLLINLFQAMILSAYEDMKQPVYEEPSDEVEVMSYLYHKLRKVFSFLTPDPRA
RDEPEFFIDMLYGQPEKNSCRHLGLKTRNINGKKMVYLVV

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------RAAPEPATDGPRPYPSLVAKTRCPT
DGPTTPVALEAVNLAGPAAGESSVPCKLLAQEPCIVPEVKI-TRNQEGVPMLV-KRNKEG
ILNVTF

PF02010 // ENSGT00700000104221_2_Domain_0 (307, 785)

KYYCPATSYILPQWQVFSVSSASE-VPDWSNPLDVPELQSGINPVYLYIPPKSL
AWGMYVFNFSLIFYVE-RNRTIAAVGSDIIYVNITKSDLQAVI-AENPNITINFTDTLLL
NGSGSSDPDS---DNPLE--GLIFSWYCTTEPKQYRGDKITVMSNKVCFP-HYTNLRWPR
ASGPVLTIPPGTLKGGGVYFFRLVIRKGGRKGFVDRTVHVLKGPAPVASISCIENCDAVL
VISDRFSLFLNCTNCSSSL-DLYEWSLLSSNGSQVPFDWVRHTTTGKTSAYLTLKAFVFR
NFSEAQFWISGHIASWSGHDLHFRHSFIINRVPQIGHCTIDPPKGVSFITKFVIQCQNFK
DNNIPLTYKIIV-SDL-HGFGQISSVKENSLGAILYLGNQSTAPPSFLPVGMLANHYAMK
IHVQVYD-SLGAFSQVTLYSTVHSPTDEFSAKDVLDQLFNFTMGTNS-SLSALLRNREFL
PAGY

ENSGT00700000104221_2_Linker_0_1 (785, 1329)

LIFIAASVLNSLKPELTLQADKARLQEYLVNQTFVLPNSTLVEISQVVMSIAKLTQ
TTSGCTLMTQKLATVRIWQANQALQQSRQRDAHRHSEQIEIMSTGILTTLSNIIKMI---
--VN-YEVVDEPFYEMELLADTILDSKVPGNETTALTASSLNMYLRKTEKWDVT-NAFGN
KLTSR-NYFNPTLNVSSVPSLPANAPISIMFCEFVDDPFPWLKYQE--NYSVEVVGFRMT
GTTPSGSVTEIVPDIAEVYITRKNLSFAAFNLTMGPSNEPGKVEESLKRTTGEFSFEVDS
SVVKEVLVHIVTEVTVIFTVLVYAGSQITPSALVATFFVPYDIPPVANQ--SDLFDSACT
V--KEARVVCIPPSLLQVIAQRS-GSTECAMIIVLQAPRFVMVPSVKLVRIALFGAYCLD
MYGIQSDWREDTCVLGEKTTWRRVHCICK-HSGRARRQLDAIRKA--GKHLQTHFLTAKV
IVIPNAVDLRLEVIKNVTQNPVTLFTVLFIMLMYLILAFWALHRDGMDRFLRHQVIIILD
NDPYDKVC

PF01477 // ENSGT00700000104221_2_Domain_1 (1329, 1444)

YLITIFTGSRCRSGTRANVFIQLKGTEGDSDVHCLSHPYFTTLRRGNINSFL
LTTKSDLGDIHSIR-VWHNNEGRAPSWYLSRIKVENVFSRQIWLFMC-RRWFSIDT---S
LDR

ENSGT00700000104221_2_Linker_1_2 (1444, 1927)

TFPVTHPDQPLNKMDFFLIDSIYKLGRNHTWFSIFSSVVARPFNRLQRLSCCLAMLM
ASLLCNIMFFNLNPEDET-EPEERRYIRSMMIGLESVLITIPVQLLVDFLFTYSQRE-PR
VALEESAPRKNSLVP--TSEHWEEYLEKWHALEMVDAQTKVAL------KLPPG------
--KSARPQEASAK---------------------------DPPVA-LHPHKKGQSKVSGP
QKKKTKASNQNAKDNKNQNAQPVTMTEPSL--------I-VSHHLEIDK-KCRVNLPWYC
VYLAWVLIFITSSIASFFIVFYGLTYGYDKSIEWLFASFCSFCLSVFLVQPSKIVFLSAL
R---GNWRKYCKN--LSWTSGYCY--TEIKLHSR---SFSPEELEK--RHEQIL--QLRN
SRMYQPLTEDEIRIFQRKKRIKRRAFLFLSYILTHFIFLALLLSLLALLRHTDSFYYNQF
IRDQFS

PF08016 // ENSGT00700000104221_2_Domain_2 (1927, 2365)

VD-LSSVTKLADIYRWLNSV--LVPLFHNEQDPTYLPDSSSKILGLPLLRQVRA
KPGDKLCPPAKSFAHTGMEQEIRCHPSYGTDLEDTRNYTDLWNTVTKRAVDKN---TNGF
TYKPPEKVWAYFSHGLLHTYGSGGYAFYFFPKQQQFNSTVRLRNLQSSNWLDEKTWAVLL
ELTTFNPDISLFCSISVIFEVSQLGVVNTSISVHSFSLADFNRETS---AEIYLYVAILI
FFLAYVFDEVYVILQERASYVRSVYNLLNFALKCIFTVLIVLFFQKNFLATGIIRSYLSN
PDDFIPFHSVSQVDHVMRIILGFLLFLTILKTLRYSRFFYDVRLAQRAIQTALPGICHMA
LVVSVYCFVYMAFGYLVFGQHEWNYSNLVHATQTIFSYCVSAFQNTEFSNNRVLGVLFLS
SFMLVMICILINLFQAVILSAYEEMKQPVYEEPSDEAEAMTYLCRKLRAIFRFLTFQPKD
EDEPEFFVDMLYGQPEKNSRRYLGLKTRNINGKKMVYLVV

MRPVFALLLL--------ALGLGRSCGHLLPPLAPLGTPVTVPFP--GEPAGSIVGFRGL
TLFSGHVHLRLR-SRTAQGDSLFLSGGR----------GHAS------SHGPARRL----
-RTHRLH--VR--------VLAAAPT-----HVDLPLSAPRRLLPPQGLSPLRRSPRGL-
-----KRTFHLGLVRPREASSAPR-L----------SPRSMVPVGPHPNAGFLDQTKCPT
DEPL-PVALEAVSSDNSQATETSVSCQIN---SCVIKKIKI-NANEDGSPVVL-TRKMDL

PF02010 // ENSGT00700000104221_2_Domain_0 (301, 860)

SLNATLEYDCPFDKTAVHRWEIFSVPKMYD-VPDWSKPLDVPELQF----RNMHLPKRSL
SRGHYAVSFSVTLTTA-KPNVRVVSDFDHIYISIVRSPLVAVI-SGGPNITVNFTDELVL
DGSKSSDPDA---GSPLD--GLHFSWYCTTNPNNYKGQKITVISKELCHP-DQDNFQWTG
AADPVLTLLPKMLKGDRVYFFRMVITKGDRTAFSDKKVHVLQGLRPTANIVCIENCDTVL
VMSERFSLFLNCPSCAVSH-DVFKWSILSSPGKEMPFDWVGQTATGRNSDYLSIKAFAFR
EFFEAKFWATLDIDTWSGVRLILKYPFVINHAPEIGECKINPANGTAFYTKFVVRCSDFK
DKNIPLTYKMIV-SDL-HGFAKISSLKENTLGSILYMGHAVNSPPSFLPAGVLANSYGIK
IYVQVYD-SLGAFSQVTLYATVHAPTDKNSSKTVLHQLLNFTMGPNS-AISPLLQKRDFL
SAGYLTYVVASVLNSMKTKSTLQADKARLREYLVNQTFVFPMGNLMEISQVVMAVATLTQ
KSSEFTHMAQKLTTVRIWE

ENSGT00700000104221_2_Linker_0_1 (860, 1327)

ANQALQQHQQKNRHFDTEQIETVCTGILTSLSNILKMI---
--AH-HQVVKDPFHVLESLADTILAGKVPGDETTIMWTTSFNVYVKKTEKENVN-GILGN
EKHCR-NCFRPALNVSSVPSLFAFSPISMMFCEFAEDPFPWLSYQE--NISAHVVGFRMT
GTAARGNMIEITPDVAEVYLGRKNLSFAAFSLIMGPDNEPSEDDEYLTKTAGGFSFEVDS
EAGKEVLVHILTEVTVPFTVLVYAGSHVTPTALVATFLVPHDIPPIVNQ--SDLFDPACT
V--KVARVVCLPPSLLKAIAQRS-QSTECAIAVVLKAPRFVTKRSDKLVRISLFYVHCLD
MFGIQSDWREDICVLGEMTTWDRVHCVCK-NTRRARRQLNTIGQA--NIPLHARYLTAKV
TVVPNPIDLQLEVIKEITYNLVTVITVLFIMLTYILLAFWALYSEETDQYLRDYAVVLPD
NDPYDH

PF01477 // ENSGT00700000104221_2_Domain_1 (1327, 1445)

ECYLITIFTGSRCGSGTRANVFVQLRGTKSTSDVHCLSHPHFTTLYRGSISTFL
LTTKSDLGDIHSIR-VWHDNEGRAPSWYLSRIKVENLFSRHIWLFMC-RKWLSIDT---S
LDRT

ENSGT00700000104221_2_Linker_1_2 (1445, 2156)

FQVTHPDEPLRRIDFFLINATDTLGKNHMWFSVFAGVVGRPFSRLQRLSCCLAMLL
SSLLCNIMFFNLNMQGT--EAEGSRYIRSIVIGLESVLITIPVQVLITFLFSCSLSR-YR
ATLHEVSPRE---ML-LESEYWEERLEKWHAHETAEALTGEAE------KLPPK------
--ESPGLRKSPSK---------------------------AASKR-GRQLKKAESKVM--
QRPNTNAN--NKTSKENEGVES---A-EPS--------S-QPGPPPLPT-KPSIVLPRWC
VYVAWFLVFATCSVSSFLIAFYGLTYSYEKSLEWLFASFCSLFLSVFLVEPTKIILLSAI
R---LHKLKYCKN--LPWVNHYRY--TEITLENM---RLNPDEKRK--QHDYIV--SLRG
TRMYQPLTEDEIRIFKRKKRLKRRALLLLIFVLIHFIFLALLLWLVALLRHTDTFYYNQF
LRNRFSVD-LATVTRLQDIYSWLNDA--LVPLLHNSLNPTFLPESASIILGLPLMRQVRA
KSGAKACLPAKNFAQTSIKGEIHCHPKYGADPEDTQNYTSSWIKISKRATDKN---TKGF
TYKPKEKRWPYHSHGLLHTYGSGGYAFYFFPDQEQSNSTERLKGLRSSKWLDEKTWAVIL
ELTTLNPDANLFCSLSVVFEVSPLGVVNTSLSVHSFALADFNRKTM---AEIFLY

PF00520 // ENSGT00700000104221_2_Domain_2 (2156, 2358)

AAILI
FFLAYVAHEGYVITQERASYVKSVYNLLNFALICVFAVLIVLLLRKHVLAAGLIQLHSSN
SAEFIPFHAVSQVDHAMRVTLGFLLFLTILKTLRYSRIFYDVRLAQGAIQTALPGIFHMA
LLMSIYFFVYMAFGCLVFGQHEWNYSTLMRATQTIFSYCVSAFQNTEFSENRVLGILFLS
SFVLLMICILINLLRAVILLAYKKMKQPVYEEPSEEVEAMTYLCGKLRTLFGFLSFRSKA
KEKPKFFVDMLYGQPEKNNRRYLGLKTRNINERKMVYLVV

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------

PF02010 // ENSGT00700000104221_2_Domain_0 (635, 860)

IGECKINPAKGIARITKFVVQCSNFK
DRNVPLTYKILV-SDV-HGFGEISSLKENTLGTVLYLGKDSTSPPSFLPVGVLANHYALK
IYAQVYN-SLGPFSQVTLYATVQAPTDMNSSEAVLNQLFNFTMGPDS-LLSTLLQNRDFL
PAGYLMYVVASVLNSMKTELPLQADKARLREHLFNQSFILPVSTLVEISQLVVAVTKLTQ
KASEFTLVSQKLATERIWQANQALQEYRQKDKHVSSEQIEIVCTGILTSLSNVLKLT---
--AR-HSVVEEHFQAVVSLADTVL--KVPEVETAILRPSNFNMKIKKNEKWNVT-KFFSN
EKLCK-F--HPTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXX
X--XXXXXXXXX--XXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXX--XXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXX---X
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXLL
SSLLCNIMFFYLNRQKEP-EPQSSKYIRSMIIGLESVLITIPVQVTIISLFVYSQRE-PQ
VPLSEVSPQKPPVSS-AASGHWEERLEKWHARETAKAQSRKPK------KPPPK------
--RKPGRRKAPAR---------------------------ATSKT-RQQVQRADSKVSDT
SRKNENAN--NPNIDDNQSAHP-----EKA--------P-PPPDLQLEE-KPRVVLPWWC
VHVAWFLVFATCSVSSFFIVFYGLTYGYEKSIEWLFASFCSFTQSVFLVQPLKIILLSGM
R---TNKPKYCKN--LPWISNYRY--TQIRLQSI---TTDPEEMRR--QHERVS--RIRG
SRMYQPLTEDEIRIFQRKKRIKRRAFLFLSYVLAHFIFLALLLGLVALLRHTDCFYYNQF
IHDQF

PF08016 // ENSGT00700000104221_2_Domain_2 (1926, 2365)

SMD-LATVTKLEGIFPWLNSV--LLPLLHNNLDPTFLPDSSSKILGLPLMRQVRA
VPGEKACLPAKHFAQSSLQGEIRCHPEYGTDPEDTKSYSGSWNRVGKRAVDKN---AKGF
TYKPPEKRWAYSSYGLLQTYGSGGYVFYFFPEEQQFNSTLRLKELQNSKWLDEKTWAVIL
ELTTYNPDASLFCCVSVIFEVSQLGVVNTSLSVYSFSLADFNPKTS---AEIYLYAAILI
FFAAYIVDEGYVIMQEGASYVTSVYNLLNFALKCIFTVLIVLFFRKHFLATSIIQFYLAN
SKDFIPFHAVSQVDHIMRVMLGFLLFLTILKTLRYSRVFYDVRLAQRAIQAALHGICHMA
LVVSAYFFVYMALGYLVFSQHEWNYSNMIRAAQTIFSYCVSAFQNTEFSSNRVLGVLFLS
SFMLVMICILINLFQAVILSAYEEMKQPVYEEPSEEAEAMTYLCRKLRSMFGFLSLRSKE
EDEPEFFINMVYGQPEKSSRRYLGLKTRNINGKKMVYLVV

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------AAHFVRRSVLPFNPDLYTGFVAKVNCTR
SGLTPAVLKVTVNTYASKVMESLVSCQKK---PCFIERLRI-QKPDLVYPIIHTKKGTQL
YLY

PF02010 // ENSGT00700000104221_2_Domain_0 (304, 786)

AKMQVNCTDLVRTEQIWKIYSVQNFTT-IPDWTKPLNPPLIWRRH-MLILQIPSFSL
DYGLYLFQFSVKI--T--TTEDVVEGSDTVFVRVEKSDLVAVF-AGGTFRTVGFSDKWTL
DGSMSSDPDS---ADRLE--GLTFTWYCTKHVSDYTN--MIVSTNGTCHP-NQVDLKWIH
FSGPTQTVVPETLRGNAIYHFRLVIQKDNRKSYADQTVSVRPGSPPLLNVICIENCGKIV
IPTDRFTLSGKCLNCRMTSRPVYHWSLFSGSFTEIQFDWASKTSTGKSSAYLSIHALTFI
KIADRSYTLLLKISTWGGRSSTFRYSFYVNSPPKIGKCAINPSSGVAFQTKFVVQCSGFS
DNNLPLMYKVIAASDL-SKRSRITSLEENTSGTIVYFGYLPKSPPSFLPIGIPSKKYTLI
IYVQVYD-SLGAFSQVALYPTVQDPVKSRPPSIMLNELLTLTTGSNA-AMTSLLQIGDYL
NVGYL

ENSGT00700000104221_2_Linker_0_1 (786, 1328)

VYMVATILNDIKTVPSIQVSKTEFRESLLNQSLHIPTTNIMEVNQIVACVSELTQ
ESTEVNRKSQELAIRKLKDVSEALKT--FRNKSLGSEQTELLSTGILTGLSNVLKASLLD
LRNVNVNAVKQSFAVMETLTETVLQGKVPGENETVMEAQTWNINLNKDEKWDVT-NTFSA
KKDCK-NCFYPTLNQGDHSELPVDAVIATVFYEFEENPFPWLAYRS--DIVTTVTGFKMT
GTKVNGDVIGIMPAVAEVILARKDKESAAFKLTLGPDKT------LPKT-TGGFSFEVD-
RNSKDIFVQILTKLKVSFHVFIYLGVNVTHTSPIASFFASHNEPAVSSG--NKSNNTDCA
I--KAPYVICLPQSLLRATAPGS-GTDKWNISIILQSPPIVRSRNRRLVSISLFNAACLD
LDGVQSQWKEGTCILGPHTSWQRIHCICKTKQ-QTKRTASRPGLG--SSKFNIKFLASKV
FVVPNPVDLEKSLLAKIHKNTVTLLTVLFIFLVYFLLALWALRKDRIDKASRDKVIVLPD
NDPFDKV

PF01477 // ENSGT00700000104221_2_Domain_1 (1328, 1439)

CFLVTLYTGSRLGAGTTADVFLQIIGQNGTSDVHCLRHPNYHSFFRGGTDTFL
LTTKNDLGDIYSLR-VWHNNGGSSPSWFLSRVKVENMYTKEFWLFIC-RKWLALDKDD

ENSGT00700000104221_2_Linker_1_2 (1439, 1929)

CL
LERTFVVTHPTVPLAKMDYFLINVANNLVDSHIWLSIFAQVVTGSFNRLQRLSCCLAVLL
CTLLINIMFFNIDKNKDV-ISIHLRYFRSIIIGIESALVTIPVQMIITALFKYSQKEPFP
HCAAQNHPKENSPFMSGNLRNWKERLQKWYLAEAPTQSKMNQRTPKL------WSNCTIS
EGAANTIAAEEENAS--------------GTS------------TAEAKAK-------QT
QSPNSNFSN--NYA-EEKN-AN----------IQEERKPLNIPFMLFRK-RPQITFCWWC
IYVSWILVIAVAGVSSFFIVLYGLSYGYKTSIEWLLASITSFFESVLLLQTLKIIIFSAL
S---SVYPKYCEN--IPWSTRDNY--LEIGLDEV---TMDADEMRE--MHYEII--RLRG
SKQYQPLQEDEVTIMRKREKIKIKAFIFLKDVVSHFVFLTLILNIAYSTESTNSFYYNQV
IHKQFSLK

PF08016 // ENSGT00700000104221_2_Domain_2 (1929, 2365)

-LSSVDKIEHIYLWVNNV--FLPLIHNSQQPTFISDSWSKILGLPRMRQVRA
KITEKKCFQPHSFVNKFVISKSHCLHKYGSDPEERGDYIGSWTKGPNTSVPHDISSYAGF
TYQSNRNHWVYYSYGELHTYGPGGYTFYFFPAEQRPNSTKRLDVLQHSNWLDEETWAVII
ELTTFNPDVHLFCSISVIFEISYFGLINTSLSVHSFTLPIFQQQSR---TQIFVFVTVLA
FLLIYITDEIHIIRQEQTMYVKNISNLINFGLKSVFFFFVFLQVIKFKMGADIVKFYLLN
PDDFIPFHTVSHVDQTLRIIMGFLAFLIVLKTLRYSRFFYDVRLAQRSILAALPGICSMA
LVVAVYFFVYMAFGYLVFGQHEWNYNNMIHSAQTVFSYCVSAFKDTAFTSNRLLGGLFLA
SFMLVMICVLINLFQAVIMSAYEDMKQPVYEEPSDEAEVITFLVHKIRRLWYFITCRTPS
ASDPDLFNSVLYGQAERYSHQHLGLKTKKINGKKMVYLVI

MWPGPALLLL----------GLGLGLGSQPPPTGPRGLPGVLRGAPGLGQG---------
------AESSV-------------RGGD------------------TGG------LS---
-------------------PRA-AP-----------------------------------
--------------------------------------RH---------ASPTPPRRCPS
GAAA--RVLLKVNSSDPAAAKANVSCQTA---PCIMQPVKI-NRKDQNAPLIL-SRDEEA
TLNI

PF02010 // ENSGT00700000104221_2_Domain_0 (305, 788)

TVRWYCPDALVIRKSWVYFSVASVND-TPDWNRPVLLPQVAV-SKGFSLHIPKYAL
PYGVYVFNFTLSIFRW-DLAWPTVTGSDIIYIWVRKRPLKAVL-LGAPRVTVKFSDELIL
NGSMSYDPEA---DIPTW--GLQFFWYCTTNPRYYSGNYVLVINQAVCHP-EQDSLNWPW
AVGSVLTIPPKTLRGNGVYYFRMVVQKQNRTAFSDKTVHVLQGLQPKAHISCIENCGPTL
GVSDRFSLFLNCPSCGR-Q-DLYSWSILSLTGHEVMFDWAGQAITRRNGPYLSIKAFAFR
NFLENRVWVSLILKSWSGMTTTLRHPVVINHGPRVGKCKINPASGISMVTKFAVECSDFK
DENLPLKYKIIV-SEL-DSIGAISSVEENTLGSVVYSGAEPITPAFFLPVGTVTDEYNVR
LYVQVYD-SLGTFSQVTLQATVTAPTVRDSSKDVLQQLLNVTMKPTS-LLSTLLQKQDWL
QAGYLTY

ENSGT00700000104221_2_Linker_0_1 (788, 1329)

VVISVLNNIKGEQELQDDRARLLEHLVKQSLTFAMNTADEIGQSVMVITKLTQ
KASDLSQADLEATSFRLRQASQDLQEYQHRHKHL--QQVEVVGTGILTSLSNLLKLI---
--NP-YYTLQDPLFVVESLSDTILANKVPGSKTTALRTSNFNMYVEKVENWNVF-KAFRN
DSLCP-NCLRATLNASTVPRLPAKAPISMMFCEFADDPFPWLTYPE--NISVDVVGFRMT
GVADNNKVIEITPDIAEVYLVRKDLTPSSFNLTVGPGIK---SDGFSKVTTGGISFEVDS
RWTGELLIHIVTNVTVLFEALVYEGCQLTPTNLMATFLVPNDIPPIVKW--SGLFDPTCS
V--KEARVVCLSSSLLRSIAQRR-FSFKYNISMVLQASRFVLKPTNKLVRIALFMVHCLD
MYGIQSDWQQSTCVLGEKTTWKTVHCVCR-NGRRSRRQLTSVKLT--YHHLHTHFVTAKV
IVVPNPVDLRLAIISNLTQNPATFLAVLFIMILYAILAFWALHRDVIDLYFRDNVVILTD
NDPFDTLC

PF01477 // ENSGT00700000104221_2_Domain_1 (1329, 1436)

YLVTIFTGSRWGSGTRANVFIQLMGTEGTSDVHCLSHPYFKTLYRGSINTFL
LTTKNDLGDIHSIR-VWHDNSGEAPSWYLSRIKVENLFNKRIWLFVC-RRWLSVD

ENSGT00700000104221_2_Linker_1_2 (1436, 1927)

T---T
LDATFSVTNPDEPLKRTDFFMIDVRDKLRKNHMWISIFTEIVPKPFNRLQRLSCCLAMLL
SSLVCNIMFFNLNQKEKI-ESRHMHIIRSMLIGIESVVITIPVQLLITFFFTYSQKN-LK
MNLDKVAPQKHPLMS-EEGLSWKERLHKWHEYEMKALPRRAAVSTSAPEEKEAF------
----------------------------------------ETSQ---------KHEKADT
QMSNKN--SSNNNQEASEGVPP---KAFSS--------Q-PHTTESVQK-KTQIILPRWC
VYIAWFLVFATSGISSFFIVFYGVTYGYAKSIEWLFASFCSFCQSVFLVQPCNILLRSGT
R---SYKPKYCKN--LSWSSKYHY--SEIRLQGL---TMTQEEMEQ--LHEDIA--YVRS
LSMYQPITEDKIQILRRENRIRRRSFLFLSYLVTHFIFLTLLLLLIFSLRHNDSFYYNQF
IRHRFS

PF08016 // ENSGT00700000104221_2_Domain_2 (1927, 2365)

VD-LATVMKLGDIYTWLHGV--FLPLLHNDPNPTFLPDSSSKILGLPLVRQVRA
RPSNKTCLLAKKFVQSSVAGEIHCHPQYGIDPEDTQHYSSVWSKAGKQSTDKA---SHGF
TYKPPGKRWVYHSYGVLNTYGSGGYVFYFFPGQQMFNSTVRLKELEGKNWLDELTWAVIV
ELTTLNPDTSLMCSISVVFEVSPLGVVNSSLSVYSFSLADFNRKTS---SEIYLYAAILI
FFCAYVVDEGYIIRQERASYIRSVYNLLNFSLKCMFALLIVLFFWKYFLATKMVQLYLAD
PEAFIPFHAVSRVDHFMRIILAFLLFLTILKTLRYSRFFYNVRLAQKAIQAALPGICHTA
LVVSIYSFMYVAFGYLVFGQHEWNYSNMIHATQTIFSYCVSAFQNTEFSGNKVLGVLFLS
SFMLVMICIFINLFQAVILSAYDEMKQPVYEEPSDEAEAVTYLCNRLKSGFDFLTTRSRD
KDQSNFFVDMLYGQPEKNTRRFLGLKARNINGKKMIYLVV

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------

PF01477 // ENSGT00700000104221_2_Domain_1 (1327, 1443)

ESFLVTLYTGSRWGAGTKADVFLQLIGQNGTSDVHCLRHPQVPSFRRGSTDRFL
LTSREDLGDICAFR-VWHSNRGPSPGWFLSRAKVENTSTRKTWLFMC-RKWLSLDKGDGL
LER---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------

------------------------------------------------------------
------------------------------------------------------------
----------------------------------LHLAAPGGRLALAWFLLLPMPLRRP-
LGPL-AWTFQLGLLGPGERLKP----------------RSVLPALPRAHAGFVAQTRCPT
DGPV-PVVLQAVNSSDHSIVQSSVSCQTG---PCVIHEVRI-NRDAGVTAVRM-TRNEGD
TLNT

PF02010 // ENSGT00700000104221_2_Domain_0 (305, 787)

TINMHCPVFQTLTQRWLVFSVPAVGD-VPDWNQPLDVPQLPIGSRPTIIHIPPASL
SWGVYLFNFSVTILTR-DPTVPRLYDADSIYVWIVRSPLVAVI-GGDANIKANYTDEVVL
DGSMSSDPEE---SNKLQ--GLRFTWYCTTNKKNYDGDQIQVASKDVCHP-DQADLRWPQ
ASNPVLTLSPGTLQGGREYFFRMVIQKGGRRAFSDKTVNVLQGPSPLAHISCIENCGSNL
IVSDRFSLYLNCTDCVS-S-DFYNWSIVSESGAEMPLDWMGQTVTGRNGAYLSAKAFAFS
HCLETNYWVSVQVTSWGGKTLEFKHPIILNHGPQTGECTVKPAKGIAFVTKFVVRCSNFT
DKHTPLTYKMIV-SDL-EGIAEISSVKENTLGPILHFGRDFTTPPSFLPVGVSADGYKLR
IFVQVYD-SLGAFSQVTLGATVEPPTSKNSSKMVLDQLLNSTMGPNS-SLSVLLRDQKFL
SSGHLM

ENSGT00700000104221_2_Linker_0_1 (787, 1328)

YVVGSVLNNMKTESTLQGDKGRLREHLVNQSSVLPVSTLEEINQVVVTVTKLTQ
KASEFTRTAQKSATVRMWQANQGLQEYQRKDKHFRSEQIEIIGSGILTSLSNILKQI---
--AP-HEVVEDPFHLAESLADTILACMVPGNKT-AMKSASINMFLEKAEKQNVT-QVFRN
KKDCP-NCFQATLNGSTVPGLPAKAVVSTMFCEFADDPFPWLHHSE--KISTQVVGFRMW
GAAENGDAIEITP-VVDVYLNRKNLTFAAFNLTVGPEEV----SESSKKTTGGFSFEVDH
REVTEVLVHIVTEVTVLFKVLVYAGSRVTPTGLVTTFLVPYDIPPIANQ--SDQFDPDCA
V--KEARVICLPVSLLQVIAQHS-QSPTCAIIMMLEAPRFVQKPNNKLVKIFLFSAHCLG
MYQIQSDWREDYCSLGERTTWQRVHCVCK-KMGRTKRHLRISELD--NIDLSTHFLTSKV
IVIPNPVDLRLKNIKKISQNPVTLFTVLFILLIYIILAFWALHRDEMDEYLRDHIIILPD
NDPYDKI

PF01477 // ENSGT00700000104221_2_Domain_1 (1328, 1444)

CYLVTVFTGSRWGSGTRSNVFIQLIGTEGASSTHCLSHPSFTTLYRGSINTFL
LTTKSDLGDIHSIR-VWHNNEGVSPSWYLSRIKVENLFSKHIWLFMC-RKWFSVDV----
FDR

ENSGT00700000104221_2_Linker_1_2 (1444, 1927)

TFQVTQPDQPSEKKG-FLIDISKRLGEDHLWFSIFAGVASKSFNRLQKLSCCLTLLL
STLLCNIMFFNLNEEDET-ESKELHYLRSMAIGVESALITVPVQLLITFLFIHSQKK-HQ
VDLDKVAPRKHPIMS-EESGYWDDRLNKWHAQETAEAKSAPQA------KLKSQ------
--VKPAPPKVSEK---------------------------VTLKS-ISRHEKEGAKASGI
HTANRTFS--NKNVAENQDAHR---GAAS---------S-KQDTKPLEK-KSQIVLPWWC
VYIAWSLVFATSIISAFFIIFYGLTYGYSKSKEWLLASVCSFLESIFVEQPCKIILVSGV
R---TNKPKYCKN--IPWSTKYHY--SQIKLTRT---RMNPDERKK--LHEHIV--KIQG
SRMYQPLTEDEIRIFQRKKRIKRRAFLFLSYILIHFIFLVLLLLLIVLLRHTDSFYYNQF
IRDRFS

PF08016 // ENSGT00700000104221_2_Domain_2 (1927, 2365)

VD-LASVTKLEDIYRWLESV--LVPLFHNDQNPTFLLDSSSKILGLPLMRQVRA
KSGEKMCLPAANFVQNSNIKEIRCRPQYGVDPEDTKNYSSFWNEVTKRQTGKN---TTGF
TYKPQGKRWVYYSYGLLHTYGGGGYVFYFFPSEQLFNSTVRLRELQGSSWLDEKTWAVVL
ELTTFNPDVNLFCSISVLFEVSQLGVVNTSISMHSFSLADFDRKTS---AEIYLYVAILI
FFIAYIIGEFYVITQERASYVQSVYNLLNLALKCIFTVLIVLFLRKHFLATAVTQFYLSN
PEDFIPFHAVSQVDHTMRITLAFLLFLTILKTLRYSRAFYDVRLAQKAIQIALPGICLVA
FVVSIYFFMYMAFGYLVFGQHEWNYSHLIHATQTIFSYCISAFQNTEFSHNSVLGVLFLS
SFMLVIICILIKLFQAVILSAYEEMKQPVYEEPSDEVEAMTYLCRRLRTMCGLMTPKSMA
KDEPEFFSDMLYGQPEK-SWRYLGLKTRNINGKKRVYLVV

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------XLISQVKV-HRDRNLPHVRL-TGKTEA
TIN

PF02010 // ENSGT00700000104221_2_Domain_0 (304, 787)

ATVETDCPDALLVRQYWQIFSVPSPLD-EPDWTNPLAVPQLHTKENSSSLRVPESSL
PSGVYVFNLVVSITTR-DAKMPVVEDSDSVYVEILRSPLKAVI-LGNSDITINFTDRLVL
NGTMSSDPDA---DDPLE--GLNFFWFCTTNERNYHDDDITVMSNQVCHP-EQADLRWTW
ASGPVLTLLPKTLKGHRVYFFRMLIQKSDRRAFSDKRVHVLQGPAPLANISCIENCGSHL
VISERFSLFLNCTNCTTSR-VFYKWSVLSPLGHEILFDWVRQTATGRNNAYLSIKSFAFR
HYLEVKLQISLSLTTWGGVTLYFRYPFIINRVPRIGECKISPAKGIAAYTKFVVHCSNFT
DRNIPLTYKVIV-SDL-HNVSEISSVQENTLGATLYLGTESLAPPSFLPVGQLASHYAVK
IYVQVYD-SLGGFSQVTLHATVQSPADENSPRTVLRQLCNLTMGSNS-LLSTLLQKQDFL
PAGYLI

ENSGT00700000104221_2_Linker_0_1 (787, 1328)

YTVASVLNNMKTELILQASKADLREHLVNQSFILPVTTLVEINQVVMTITELAQ
KGSELTQVAQKLLGVRLRQVNQALQNYKQRDRHFRSEQIEIVSTGIAASLSNILNLT---
--SY-REVVQHPFYVLESLADTISSCKVPGNETTVMRTRKFNMYVKKIEKWDVT-EVFKN
EK----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------LQLEVIRNVNQNPVTLLTVLFIMLVYLVLALWAVRKEEMGHFLRENVIVLPD
NDPYDNI

PF01477 // ENSGT00700000104221_2_Domain_1 (1328, 1441)

CYLVTIFTGSHWGSGTRANVFIQLMGTESTSDVHCLRHPHYKTHYQGSINTFL
LTTKSDLGDIYSIR-VWHNNEGRAPSWYLSRIKVENLFHGCIWLFIC-RKWLSVDT---S

ENSGT00700000104221_2_Linker_1_2 (1441, 1927)

LDRTFHVTRPDEPLTRWDFFFIDVTNQLGENHMWFSIFANVVAKSFNRLQRLSCCLALLL
SSLFCNIMFFNLNQQE-T-AFTQVHYIRSMVIGIQSALITVPVQVIISFLFIYSQKKPPR
VNLDEVSSQKHSLMS-EQSGYWEERLEKWFAQETTTAHGGEAG------KLSSK------
--GSPGLPKAAVH---------------------------ATLET-QSQLATAEPKAPQT
HQTMTNSNNSN--IKDDRDVHS---E-ASP--------S-QQKPELPHK-KPMILLPWWC
VYLAWFLVFAISSISSFFIVFYGLTYGYGKSMEWLFTSFCSFSQSVFLVQPLKIMLQSGF
R---TQQPKYCKN--LSWVTRYHY--AELRLGGM---RRDPNEMQM--LHQHIT--QMRG
SRAYQPLTEYEIRVFKRKKRIKRRAILFLSYILTHFIFLALLLCLITLLHSTDSFYYNQF
IRDQFS

PF08016 // ENSGT00700000104221_2_Domain_2 (1927, 2365)

VE-LATVTKLEHIYRWLNRV--LVPLLHNSRNPTFLLDSSSKILGLPSMRQVRA
KPGKKVCLPAKKFVPDSARREFHCHSQYGVDPEDTKNYSNSWNEVDKQAIRKD---TPGF
TYKPQAKKWVYYSYGLFHTYGSGGYVFYFFPEQQQFNSTLRLRGLQGSNWLDEKTWAVIL
ELTTYNPDANLFCSISVIFEVSQLGVVNTSISVHSFSIPDFNHKTS---LEIYLYLAILF
FFLAYIFDEGYIILQERVSYLWSVYNLLNFALKCIFTVLIVLFFWKHFLTTDVIQFYLTN
PEDFIPFHAVSHVDHIMRIILGFLLFLTILKTLRYSRFFYDVRLAQRAIQTALPGIYHMA
LVVSVYFFVYMAFGYLVFGQHEWNYNNLIHATQTIFSYCVSAFQNTKFSNNRVLGVLFLS
SFMLVMICILINLF-AVILSSYEEMKQPVYEEPSDEAEAITYLYHRLRTVFRCLTCQSKA
KDEPEFFTDMLYGQPEKNSQRYLGLKTRIINGKKMVYLVV

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------A

PF00520 // ENSGT00700000104221_2_Domain_2 (2243, 2358)

FLLFLTILKTLRYSRAFYDVRLAQKAIQIALPGIFHMA
FVVSIYFFVYMAFGYLVFGQHEWNYNHLIHATQTIFSYCVSAFQNTEFSHNRVLGVLFLS
SFMLVMICILINLFQAVILSAYEEMKQPVYEEPSDEVEAMTYLCRRLRTMCGLMTPKSTA
KDEPEFFSDMLYGQPEKKSQRYLGLKTRNITGKKKVYLVI

-------PVA-QA-G------VQWHDLGSPQPPLPRF--KRFSWE----PAPLLRGAPGL
GVRGGRTLLSL-RPSAVRAGGVVLSGRG----------SLCFPRGGAGR-----------
-RWYCLD--LRVLLSAQRLPRPAAPA-----LVDLQLSARGGRLSLTWSAQLPRSPGRL-
-----AWAFRLRLLGPGATRPASL-AAR--------VSQRSATPGPRPQPGFVARTECPT
DGPA-RVMLQAVNSSRHRAVESSVSCQIN---ACVIQRVRI-NTDQRGAPVRL-SMKAEA
TIN

PF02010 // ENSGT00700000104221_2_Domain_0 (304, 786)

ASVQLDCPAARAIAQYWQVFSVPAVGH-APDWTQPLDLPQLEIRNSPLFIHIPSNSL
QWGVYVFNFTVSITTG-NPKMPEVKESDAVYVWIVRSSLQAVM-LGDANVTANFAEQLIL
DGSTSSDPDA---DSPLQ--GLQFFWYCTTDPRNYRGDRIILGSKEVCHP-EQANLKWPW
ASGPVLTLLPETLKGDHVYFFRMVIRKDSRTAFSDKRVHVLQGPKAIAHITCIENCERNF
IVSDRFSLFLNCTNCAS-R-EFYKWSILSSSGGEILFDWMGETVTGRNGAYLSIKAFAFR
HFLEAEFSISLYLACWSGVTSVFRHSFVINHGPQIGECKINPAKGIALITKFVVQCSNFR
DKHVPLTYKIIV-SDL-HSVGEISSIKENTLGTILYLGPQSTAPPSFLPVGMLANQYALK
IYARVYD-SLGAFSQVTLHATAQAPTDKNSSKTVLNQLLRFTMGPSS-LLSTLIQKQNFL
PAGYL

ENSGT00700000104221_2_Linker_0_1 (786, 1329)

LYIVASVLNNMKTELPLQDDRVNLRKHLVDQSFLLPVGTLVEIGQVVMTITKLTQ
KPSEFTWDAQKRATVRVWQANQALQEYQQKDKRFRSEQIEIVSTGILISLSNILKMT---
--SP-HQVVKDPFYVIESLSDTILANKVPGNKTTSMRTPNFNMYVKKVEKWGVT-QVFRN
EKHCR-NCFYPTLNVSSVPGLSANGPISTMFCDFTNDPFPWLNDQE--NTSVEVFGFRMT
GVADNGSVLEITPDVAEVYLVRKTLTFAAFNLTVGPNRE---VDGSLKKTTGGFSFQVDS
RMLREVLVHIVTEVMVLFTVLVYTGSQITPTALVATFLVPHDIPPVASQ--SALFDPACT
V--KKARVVCLSVSLLQLIAQHS-HSPHCTVSIVLQAPHFVMKLNDKLVRISIFSVQCLD
MYGIQSEWREGYCVLGEKTSWHEVHCICK-NVVRARRQLGTIGLT--SIHLHTHYVMAKV
IVIPNPVDLRLNITKSLHQNPVTLFTVLFIILLYVVLAFWALYRDEMDQHLRGHVIVLPD
NDPYDNVC

PF01477 // ENSGT00700000104221_2_Domain_1 (1329, 1445)

YLVTIFTGSRWGSGTRANVFVQLRGTVSTSDVHCLSHPHFTTLYRDSINTFL
LTTKSDLGDIHSIR-VWHNNEGRSPSWYLSRIKVENLFSRHIWLFIC-QKWLSVDT---T
LDRT

ENSGT00700000104221_2_Linker_1_2 (1445, 1927)

FHVTHPDEPLTRKDFFFIDVSGNLRKNHMWFSIFASVVAKTFNRLQRLSCCLAMLL
SSLLCNIMFFNLNRQEQT-ESRERRYMRSMMIGIESVLITIPVQLLITFLFTCSQRK-PQ
ADLKEVSPQKHPLMS-EASEHWEEYLRKWHAYETAQVHPREVA------KPTSK------
--GKPRLPKASPK---------------------------ATSKP-KHRHRKAQIKTPET
LGPNTNS---NNNIEDDQDVHS---E-EHP--------S-QKDLQQLKK-KPRIVLPWWC
VYVAWFLVFATSSICSFFIVFYGLTYGYDKSIEWLFASFCSFCQSVLLVQPSKIILLSGF
R---TNKPKYCKN--LSWSTKYKY--TEIRLDGM---RMHPEEMQR--IHDEIV--RIRG
TRMYQPLTEDEIRIFKRKKRVKRRALLFLSYILTHFIFLALLLILIVLLRPTDCFYYNQF
IRDRFS

PF08016 // ENSGT00700000104221_2_Domain_2 (1927, 2365)

MD-LATVTKLEDIYRWLNSV--LLPLLHNDLNPTFLPESSSKILGLPLMRQVRA
KSNEKMCLTAKKFVQNSIRREIHCHPKYGIDPEDTKNYSGFWNEVDKQAIDES---TNGF
TYKPQGKQWLYYSYGLLHTYGSGGYALYFFPEQQRFNSTLRLKELQESNWLDEKTWAVVL
ELTTFNPDINLFCSISVIFEVSQLGVVNTSISLHSFSLADFDRKAS---AEIYLYVAILI
FFLAYVVNEGYIIMQQRASYVRSVYNVLNFALKCIFTVFIVLFLRKHFLATGIIQFYLSN
PEDFIPFHVVSQVDHIMRIILGFLLFLTILKTLRYSRFFYNVRLAQRAIQAALPGICHMA
FVVSVYFFVYMAFGYLVFGQHEWNYSNMIHSTQTVFSYCVSAFQNTEFSNNRILGVLFLS
SFMLVMICVLINLFQAVILSAYEEMKQPVYEEPSDEVEAMTYLCRKLRTTFSFLTSRSKA
KDEPEFFIDMLYGQPEKNSCRYLGLKTRNINGKKMVYLVV

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------ASRFIQRSVLPFRPDGYAGFVEKANCAT
SSLEPVILEASLDKYGSKVLRTPVACVQN---PCYIKRMKI-LLNAPIERGLI-A--PHY
DNSVL

PF02010 // ENSGT00700000104221_2_Domain_0 (306, 786)

VEVICSVPYNSSHHWSVFKLPSDTDPKPS------KENIVTGQ-KSTFSVPSTIL
KPGTYRLNYTLTI--T--TSEQVATSSTFRDFTVSPPILYAYI-EGGPARSVPFNKRWTL
DGSRSRNVWY---YTDPK--IMKYRWYCTTNYTYFIIGNLPASSRDSCLP-KLPDVRWFK
ATSPVVTVSPGTLRGNRTYYFILVVSLFSNRAYAYQNVTVEPGPPPKMKFSCIENCGKLL
VVPDRLSLSSKCLDCGAR-PMKYLWSLMDSTKTEIPFNWTHWSTTGRTSTYLTIKAFAFK
DFQDKMCSAILHASGWGGNFLVANHSFYVNSPPRNGYCDIHPNKGVALFTKFVVRCSGFI
DENLPLHFKVIA-SNF-WGVDNSSTVADNTLGTVMYFGLESVTPPSFLPIGMPVNHYMVR
VYAQVYD-FLGAFSQVTLHATVTSPQDRASPNTVLNYLLSLTQNTTGTMMTTLFQKGDFV
QAGYL

ENSGT00700000104221_2_Linker_0_1 (786, 1328)

AYLAVSLLNDVTPPPNLQAQYSEIQHHLLNVCRHLPTTTLEEINQVTVMIMGLTK
KGSGLTAEGQKAATSRLIEINLALQRLKEKEKEFLSEQIQIVSTSILSCLSNILKSE---
---INEDMINETLHVIELLASTVLAVKSPGEMETVVTSPHLRISVWKDEKRNVN-DAFLA
QKDCQ-NCFYPTLRKNDSEYLARGGPISTAFYEFKQELST--SEDT--GLSTDVVGFQMS
EIKENGNIQEVIPDLVEVFLLRKNLSGAAFNITMGPDKD------LPETTSGVFTFLVF-
GTDEEVLIQIITEVKVMFKAFIYEGSNVTHSLPIASFLVPPDMPTVANE--SKLFDPTCK
VKFKVPRLICLSQSLLEATVQDY-FASNWSISVVLQTPPIVMVPSDQLVNISIFLAECLK
MEGNEKEWDKEDCKVGDKSSWWRIHCICEIKS-KPMNESKPGESW--KRLSRIKYLSARM
IVIPNSIDLRMEILKTIPQNPVAVFTVVLIIFTYLVLAFWAMHKDETDRIRREHVILLPD
NDPYDHI

PF01477 // ENSGT00700000104221_2_Domain_1 (1328, 1434)

CYLVTFYTGSRLGAGTKADVFVQLLGTDASSDVHCLSHPNFTTFYRGSTDSFL
LTTRSDLGNLRAIR-VWHNNEGSDPSWYLSRVKIENIFNRNIWLFLC-RSWLS

ENSGT00700000104221_2_Linker_1_2 (1434, 1929)

INK---S
LEQTFPVADKGQPMNKKDYFQIFASDNLGTRHLWLSVFSSVVTGPFNRLQRLSCCLTLLM
NTLLCNIMFFNVEKEVEV-SPMELKFLRTIMRGIESALICEPMQILLVSLFTYSHRKVKP
VAITQVAP-HVHPFMKSPFQNWKERLEMWYSLETAHKQAPE-------------------
---------TEEKPP--------------NSEAFLEK-NMTNTKPVDVAISREEQTSEES
LSSSASLVRRSDAAKEDQGAEP---------ASEESPQKSPKKVLLFEA-KPRFFFHWWC
IYVAWLLVIGSSGVSSFFIIMYGLTYGYEKSMDWLISSMTSLTESIFIIQVAKILLVSGI
R---SGRATYCKN--IPWASRYNY--LEIRLQEL---ELNADDSRE--LHYEII--RIRG
TRMYQPLVQDEIRIFRRRKKIRDRALIFLKNIISHLIFLTLLFCIISLARPSHSFHHNQA
MQNQFSLK

PF08016 // ENSGT00700000104221_2_Domain_2 (1929, 2365)

-LTTITKLDDIYRWLTGV--WLPLIHNDENPTFISNSWSKILGSPKMRQVRA
KSIKRECFLSGTMVDKLMKKGIHCHSQYSQVMEDQKNYGRLWSTRSKFSVDPR---PVSF
TYEPNLRKWSYYSYGLSHAYGSGGYPFYFFPTQKQYNSTVRLQELQESRWLDEKTWAVIL
ELTTFNSDTSLFCTISIVFEASPFGVINPSLAIHSFSLPLIYRESY---FELYLYGGALM
FIVLLLIDEATIIYWEKENYVKNVFNFLSLGLKLMFLMLILLFFVKFRLTKDILGFYLQN
PDGFTPFHVISLVDQGLGIILGFLGFLTILKTLTYSRFFYDIRLAQTTILAALPGIFHMA
LLVGVYIFMYVTFGRLVFGQHEWHYSNLIHSTQTIFSYCVSAFRDTAFLNKEVLGGLFLA
SFMLVMICILINLFQAVFLSTYEEMKQLVYEEPAAEGEAITFLFHKVRNLWRTLTCRKPF
REQPTYFSDILYGHPGNQSHQRLGLKSRNINGKRVTYVAV

-------------------------------PAPPRGRSE---------------GVRAC
RRGGAAAGASV----------------G----------ALASPAGQRGS----SGFAHLP
NS--C-----PTPARGL--PPAGDPV-----GAAAAESLGSGHFQALWSPP---------
-------------------------RKPGAHT-FLEASSALPAGDPRLYAGFVAQAKCPT
DGPT-PVVLEAVNSDGPQAIESSVSCQLSAQLPCVVSLVRI-NRDR--DPVVL-SRRMHT
TLNA

PF02010 // ENSGT00700000104221_2_Domain_0 (305, 786)

TFKYDCLEATLFNPSWQVFSVPSVSD-VPDWNQPLDVPQLSLGRTPAYMEIPPNSL
SWGVYVFNFTLTIYTR-KSNTPRATGSDIVYVTVLRSPLQAVVIPARPNITMNFTDSLVL
DGSRSSDPDS---GNSSE--GLLFSWYCTKDKNNYQGETIIVVSRKVCLTAKQTDLRWKE
ASGPILSFLPRTLRGKDAYYFRMVIRKGSRTAYADRRVHVLPGPRPAAHISCIENCNRNL
IISDRFSLFLNCTGCAGDR-DYYKWSILSSSGKEIIFDWARQTTTGRARAYLTIKAFAFR
DFSEAEFLVSVYSITWSGAGLTLRYSFAINYAPQPGQCNINPAKGLSLLTKFVIRCTNFT
DKNIPLAYKIVV-SDL-YGFGQISSVKENTLGAILYWGHESTSPPSFLPVGGLANHYVMK
IIVQVYD-SLGAFTPVTLHATVRAPTDKISSKNVLDRLFNFTMGPTS-SLSTLLDQREFL
PAGYL

ENSGT00700000104221_2_Linker_0_1 (786, 1329)

IYIAASVVNSMKADLTLQADKTRLREHLVNQTFVLPNSTLEEISQVVVCMAKVTQ
TTSGFTRMAQKLATARVWQANHALRQSHQKHKSFSSERIEIVSTGILTSLSNILKLS---
--VP-YEVVDEPFYGLEFLADTILAGMVPGNETTAMTASSFNMYLKKTEKRDIN-EAFTN
KKLGR-NYFRPVLNASSVPLLPENAPISTMFCEFADDPFPWLSQQE--SYPAEVVGFKMT
GIPAKGNVLEITPDVVEVHIVRRNLSFAAFNLTVGPDNAPHKVNEPFKRTTGEFSFEVDS
SAVNEVLVHIMTEVTLVFTVLVYAGSEITPAALVATFFVPYDIPPIANQ--SDLFDQACV
V--KKARVVCLPPSLLQVIAQRG-SSSECTVTMALQAPRFVMAPSNKLVRIALFSVQCLD
MYGIQSDWREDNCVLGEETTWDRMHCICK-NPRRARRQLATIKKA--SLHLQTHFLTANV
IVVPNPVDLRLEVIRNVTQNPVTLFAVLFIVLVYVFLAFWVLHKDAMDQLLRQYVIILPD
NDPYDKVC

PF01477 // ENSGT00700000104221_2_Domain_1 (1329, 1445)

YLLTIFTGMRCGAGTRANVFIQLKGTEGDGNVHCLSHPYFTTLSRGSINTFL
LTTERDLGDIHSIR-VWHNNEGRAPSWYLSRIKVENLLSRHIWLFLC-RKWLSVDT---S
LDRT

ENSGT00700000104221_2_Linker_1_2 (1445, 1927)

FHVTPPDQPLEKKDYFLIDSIYKLEKNHMWFSVFSGVSARPFNRLQRLSCCLAMLL
SSLLCNIMFFNLNRKEDT-DPKETKYIRSMMIGLESVLITIPVQLLIAFLFTYSQEE-PR
VTVEEVSPQKTPLMR-VPSEYWEEHLKKWHAQETDGAPARAAS------KLPPR------
--KSPKAPKAPE----------------------------------QHRGKKAEGKVSRP
--RDVNMNASNRNAEDDQEAAP---AQPP---------S-QANPPELQE-KHRIVLPGCC
VYVAWFLVFATCSISAFFIVFYGLTYGYEKSIEWLFASFCAFCLSIFLVQPSKIILLSGV
R---TSRPKYCKN--LSWASKYHY--TEIKLFHA---KMGPEEMKR--RHEQIT--QLRS
SRMYQPLTEDEIRIFQRKKRTKRRALLFLSYILTHFLFLALLLRLVALLRHTDSFYYNQF
IRDQFS

PF08016 // ENSGT00700000104221_2_Domain_2 (1927, 2365)

VD-LGTVTKLEDIYRWLDHV--LLPLLHNDPNPTFLPDSSSKILGLPLLRQVRA
KPGEKLCPPAQDFVQNSTDRDIHCHPEYGTDPEDTRSYSNVWDKVGKRAVDKN---TDGF
TYKPQEKTWAYFSYGLLHTYRSGGYVFYFFPEQQQFNSSMRLGELQSNNWLDEKTWAVIL
ELTTFNPDVSLFCSISVIFEVSQPGVVNTSMSVHSFSLADFDRRTS---AEIYLYAAVLI
FFVAYVVDEGYIILQERASYVTSVYNLLNFALKCIFTVLIVLFLRKHFLAAGIIQFYLSN
PVEFVPFHAVSQVDHIMRIILGFLLFLTILKTLRYSRFFYDVRLAQRAIQTALPGICHMA
LVVSVYFFVYMAFGYLVFGQHEWNYNNLIHATQTIFSYCVSAFQNTEFSSNRVLGVLFLS
SFMLVMICILINLFQAVILSAYEEMKQPVYEEPSDEAEAMTYLCCKLRTVCRCVFFQPKA
RDKPEFFEDMLYGQPEKKSRRYLGLKTRNINGKKMVYLVV

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------MAANSSRHGAVGPSASCQID---ACVIRSVRI-NTDRRGAPVRL-SRTAEA
TLN

PF02010 // ENSGT00700000104221_2_Domain_0 (304, 788)

ASVQMDCPRALAVSQHWQVFSVPAVGH-APDWTQPLDLPQLQLGRSPLFLHIPRHSL
SWGVYVFNFTVSIVTG-NPKMSEVTDSDAVYVWIARSPLQAVL-LGDAHVTANFSEPLIL
DGSTSSDPDA---DSPLQ--GLQFLWYCTTDPRNYRGDPIILGSKDVCHP-EQANLKWPW
ASGPVLTLSPETLKGDRVYFFRMVIRKDSRTAFSDKRVHVLQGPEAIAHITCIENCERSL
TVSDRFALFLNCTNCVS-R-DFYKWSILSSSGGEMLFDWMGETVTGRNGAYLSIKAFAFR
YFLEGELWISLHLASWSGRASVFRHSFIINHGPQVGECKINPAKGIALMTQFVVQCSDFR
DKHMPLTYKIIV-SDV-HSVGEISSVKENTLGTILYLGPQSTAPPSFLPVGTLANQYALK
IYAQVYD-SLGAFSQVTLHATAQAPTDKNSSETVLNRLLSFTMGPSS-LLSTLIQKQDFL
PAGYLMY

ENSGT00700000104221_2_Linker_0_1 (788, 1329)

VVTSVLNNMRTELSLQDDRVSLREHLIEQSFLLPARTLVEIGQVVMAVTKLTQ
KPSELTWDAQKRVTMRIWQANHALQDYQQKDKHFRSEQIEIVSTGILMTLSNILQLT---
--SS-DQVIKDPFCVIESLSDTILANKVPGNETTSMRTPNFNMYVKKVEKWAVT-RVFRD
EKHCR-NCFYPTLNVSSVPGLSANAPISTMFCDFTNDPFPWLNDQE--NTSLAISGFRMT
GVADNGSVLEITPDVAEVFLVRKNVAFAAFDLTVGPDRE---ADGSSK-TTGGFSFQVDS
RVPREVLVHIVTEVTVPFTVSVYTGSQITPTALVATFLVPHDIPPVASQ--SALFDLACT
V--KKARVVCLPVSLLQLIAQHS-HSPYCTVSIVLQAPRFVMKPSDKLVRISLFSVQCLD
MYGIQSEWREGYCILGEKTSWHEVHCVCK-NLVRARRQLGTLGLT--SIHLHTHYVMAKV
LVIPNPVDLRLNI-KTLYQNPVTLLTVLFILLLYVILAFWTLYRDEMDQFLMGHVIVLPD
NDPYDNLC

PF01477 // ENSGT00700000104221_2_Domain_1 (1329, 1445)

YLVTIFTGSRWGSGTRADVFVQLRGTVSTSDVHCLSHPHFTTLYRGSITTFL
LTTKSDLGDIHSIR-VWHNNEGHSPSWYLSRIKVENLFTRHIWLFIC-QKWLSIDT---T
LDRT

ENSGT00700000104221_2_Linker_1_2 (1445, 1927)

FQVTHPDEPLTRKDFFFIDMSTKLQKNHMWFSIFAGGVNKTFSRLQRLSCCLAMLL
SSLLCNIMFFNLNRQEQT-ESRERKYIRSMMIGIESVLITIPVQLLITFLFTCSQRK-PQ
ADLKEASPQKLPLMS-EGSGHWEEFLRKWHANETAKELPREIA------KPASQ------
--GKPRIPKAAPK---------------------------ATPKP-KHTHRKAQIKTPET
RRPNTNS---NNN-EDDQNVPS---E-EQP--------S-QRELQELKK-KAQIVLPWWC
VYVAWFLVFATSSVSSFFIVFYGLTYGYDKSIEWLFASFCSFCQSVFLVQPCKIILLSGF
R---TNKPKYCKN--LSWSTKYQY--TEIRLDGM---SKHPDEMQR--IHDHIV--RIRG
TNMYQPLTEDEIRIFKRKKRLNRRALLFLSYILTHFIFLALLLVLIVLLCHTDSFYYNQF
IRDRFS

PF08016 // ENSGT00700000104221_2_Domain_2 (1927, 2365)

VD-LATVTNLEDIYRWLNNV--LLPLLHNDLNPTFLPESASKILGLPLMRQVRA
KSSEKMCLSAEKFVQSSIRREIHCHPTYGTDPEDTKNYSRFWNEVDQQATDES---INGF
TYKPQGKQWLYYSYGLRHTYGSGGYAFYFFPERQQFNSTLRLKELQESNWLDEKTWAVVL
ELTTFNPDVNLFCSISVVFEVSQLGVVNTSISLYSFSLADFDRKTS---VEIYLYVAILI
FFLAYVVDEGYIIMQERASYVRSVYNLLNFALKCLFTVLIVLFFRKHFLATGIIQFYSSN
PEDFIPFHAVSHVDHIMRIILGFLLFLTILKTLRYSRFFYDVRLAQRAIQAALPGICHMA
LLVSVYFFVFMAFGYLVFGQHEWNYSNLIHSTQTIFSYCVSAFHNTEFSNNRILGVLFLS
SFVLVMICVLINLFQAVILSAYEEMKQPVYEEPSEEVEAMTYLCRKLRTLFSFPTSQSKA
KGEPEFFTDMLYGQPEKNSRRFLGLKTRNINGKRMVYLVV

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------ATQFIPDSVLPFNPALYTGFVAKMKCIS
SKFVLMVLKATFNLYGSKVIESRLACHQN---ACSIAKINI-QRSETSKFILHYAPGTEF
TLAT

PF02010 // ENSGT00700000104221_2_Domain_0 (305, 758)

DTQINCPGPKQTDVIWNIYKVENRAS-TPDWSKPFNPPGIRK-RNDMTLNIPSSSL
DDGLYVFNFSMKLKSL-DT-WDITKSSDSVLVEIGPDNLMAAI-VGGNFRTVSFSDQWIL
NGSIFSNGEM---IQSF-QKGLSFIWYCTKHKSDYASMTL--SRNGKCHP-DQADLKWIT
SSGPVQTVRPKTLQGNNTYYFLLMVQYGSRTARAKQAVYVRIHSPLILNVACIENCDKAL
VPTERFCLSGKCLNCRPNQ-PSYYWSLYSIQYNEIDFDWFSKTTTGRSSPYLRINAFAFE
TMTEHSYILTLKVSTTEGQTAIYKYSFYVNGPPRLGKCVLNPNIGIAFLTKFIIQCSGFE
DKNEPLTYKVIA-AYNQIETSTISSIENNTLGIIIYSGHDYKTPRSFLPNGVPSQNSALV
IYIQVYD-ALGASSQVTLQATVHDEKKSKSLDIIHHK

ENSGT00700000104221_2_Linker_0_1 (758, 1327)

LHSLINGQSA-PMTTFRITKDYF
DIGYFVYMVASVLNNVETSFARQDSTSDLRQILLNMSAEIPANTAEEINQVILSICQVTH
KTMEINEESQLIAIKKLKEASKALIR--LRDKDFSSKETDILSSGILIGLSNVLKASLSD
YKKVNINVIKETISVMEILADLVLQDKVPGENETIMKTENWRIHLQKYMKGDLS-GNVSN
RKYCR-NCFYPKLKEGRHAELNVDAVVTTVFYVFEINPFPWLLFTE--DIGTIVTGFKMT
GTQTNGDVISITPDLVEIIMARKDE--VIFDLTIGPDKM-------LSKTTGGFSFETK-
RSTKDIFIQIVSKRNITFQVFIYPGHNISRPPL-ATFTVSHHSPPTPIE--NDTTIPECA
V--VAPYILCLPQSLLWSPVYSN-RGDKVSISIVLQSHPFVREQTTKIVRIAVFAAECLD
LDGIEKQWKEGTCSLGPETSWSKIHCICK-AKELSTIT---------GSPSHSPTFLAGK
IKYSNPVNVGKSQSTQIHQNLVILLTLLFIFLLFIVLAIWAMRKDRADINSVEHVIVLPD
NDPFDK

PF01477 // ENSGT00700000104221_2_Domain_1 (1327, 1435)

VCYLVTVYTGSRLGAGTTADVFIQLTGERAVSDVHCLRHPEHFTFFRGAVNTFL
VTSKIDLGEIYCFR-VWHNNEGSSPNWFLSRIKVENIYTKKSWMFIC-RKWFAL

ENSGT00700000104221_2_Linker_1_2 (1435, 2172)

DKDDGL
IDRSFIVAHPKAPLHKLDFFMIDFANTVADNHLWLSIFAHVCTGSLNRLHRLFACLTILL
CILFVNIMFFSADEERQM-FSEHIQYLRPILIGVQGAFISIPLQMIVTAFFKYSQEEPSV
QSTTHALPAQYSTFMFGNLSNWKECLQKWYLIETASKDLGDHLQEFPPKAL---------
--DSPKQEQS------------------------------KTITWRHTSKNWTNCTIPEG
AKTNNNV--NNNYLEKHKSYLQ----TRS---------P-NIANMVFCL-RPQIKVSWWN
RYVLWIFVLVTSTLSSFFILLHGLTFDYEASVEWLVASVISLWVNVFLLQIMNIAIFSSL
K---TLYPKNCKS--LQWSSKAAY--LEIKLSDI---NMDADDMRE--LHYDLV--RMRG
TKQYHSLEEDEITIFKKRQKIQRQAFVFIKDVVCHFVFLILILNIAYSMENTTSFYYNQD
IHNKFSNG-LSRVNKVEDIYTWLRKV--FLPLIHNDDKPTYLSETRTKILGVPRMRQVRA
NITKKACFYQQSFVHKFVISKSHCLHKYGIDEENQRDHLGSWTLPADKP-------VFEL
HVSIGTGRWKYSSYGELNTYGAGGYTFNFYSEENLRNSTKRIDFLEESSWLDENTWALIV
EMTTFNSDVDLFCSISVIFELSYLGPINTTLWIHSYKLPVFKELSK---TEKFVYVAVGY
MLVFYIIDECY

PF00520 // ENSGT00700000104221_2_Domain_2 (2172, 2358)

VVERQRLKYIKTVSNLINLGIKGVCLFFLLQLGFKFELASDLSELHLLQ
PDEFIPFHRVSHVDRTLRITLGFLAFLIVLKTLRYSRFFYDVRLAQRSILAALPGICSMA
LVVAVYFFVYMTFGYLVFGQYEWNYNTMTHSAQTVFSYCVSAFKDTAFESNRVLGGLFLA
TFMMVMICVLINLFQAVIMSAYEDMKQPVYEEPSDEAEVVNYLFNKVRRICFFITCKKAS
TADTELFNRVLFGHPERRNKHHLGLKARKVNGRKIVYLVI

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------QRNESHWSEQTEIQTSGILKCLSNILRAALLR
RS-----AVTQVFSIMENLTEIVFQGKVPGEEDTVMETSNWKITLMKDENWNVA-NAFST
TEACR-NCFYPTLKTGNSSRLSYDAVISTALFEFDENPFPWLNYTS--EIATAILGFKMA
ETKANGDLQGILPEEANVLIARKDTESSTFQLAMGPDKT------QTYT-TGGFSLEVN-
RDTKIIYIQILTKLQVAFQVLVFTGTNVTQNFPIASFDAFHNMTTVASK--TKAVDEECN
I--KAPYIICLPESVLKVAAQGS-GAQSRNISIILLTPYITRYPNMRLVSIHTFSDHCLF
LGGVQNQWREDMCRLGSLTNWQRVHCVCSMKR-SHRSRSVLTASN--TSTFDIKFLAAKV
IVTPNTVDLKRNLIADIPKNPVTLLTVLFIFSAYFLLSLWAVRKDRAEMVSKDKIIVLPD
NDPFDK

PF01477 // ENSGT00700000104221_2_Domain_1 (1327, 1445)

VSFLVTLYTGSRWGAGTNADVFLQLIGQNGTSDIHCLRHPQFPAFRQGSTDCFL
LTTKEDLGDILAFR-VWHNNRGPSPGWFLSRAKVEHVSARKTWFFMC-RKWLALDKGDGL
LERT

ENSGT00700000104221_2_Linker_1_2 (1445, 1926)

FSVTNPKAPLSRKDYFLIDLASGLKEGHLWLSVFAQVLPGTYSRLQRLSSCLTILL
LNLFVNIMFFNADKNEE--SPRHLRYMRSIAIGIECALTTIPVEMIIMALFKYSQKNP--
--------QRNLPLLPGNLKTWRERLQKWKLSESNSQSPTHHRKTRSLGAPQNSRKFPIA
EGGASTTRDKEQTEK--------------NSP------------PK------------RR
LLSNSNFSN--NYA-KEA--GN----------FQEESKLPSVTSAPLCK-RPPVVFCWWC
IYISWVLVIIVSGVSSFFIVLYGLSYGYQTSLEWLLASATSFIQNVFFVSIIKISCYSAL
N---TVRPKYCEN--VPWFTQDLS--SEIKTDKE---ALNEEEMQE--KHFKLA--QIRD
TEQYKPLEDGKIAKMLEAAKMKFKTFSFIKDVIGHLVVLAVVLHFAYSTENTNCFHYNQF
IRNQF

PF08016 // ENSGT00700000104221_2_Domain_2 (1926, 2365)

SPR-LPAVVKLADIYMWVNNT--FLPLIHNDVQPTFLTDSSSKIIGLPRMRQVRG
KGTEKTCFHPHSFVNKFVISRSHCLHKYGRDMEEKGDYAGTWTKVANRSFSEDTSSYHGF
TYQPNRTPWTYVSYGDLHTYGPGGYTFYFFPEEGKYNSTTRLDLLQESNWLDEKTWAVII
ELTTFNSDGNLFCSISVIFELSYLGIIKPTLSVYSFAVPIFHQQTK---GQQLFFLTAVA
FLLVYIADGLYSMVQG-KEDTKNISGTISFILKSAFFLLVPFQVLKFKMGADIVHFFLLY
PNDFIPFHAVSHLDQNLRNTLGFLAFLAVLKTLKYSRLFYEVRLAQRSILAALPGISSMA
FVVVVYFFIFMAFGYLVFGQHEWNYSNMIRSAQTVFSYCVSAFRDTAFSSSRLLGGFFLT
SFLLVMTCVLINLFQAVIMSAYGDRKQLVCEEPPDEARAVAFLLQRMKQMLCFLICRTAK
RSGPNLCHGVPNGQ----AERHSGLKKRKGNGEQMVYLVI

MWPGPALLLL----------GLGLGLGSQPPPPGPRGLPGVLRGAPGLGQG---------
------AESSV-------------RGGG------------------TGG------LS---
-------------------PRS-VP-----------------------------------
--------------------------------------RR---------ASPTLPRRCPS
GAAA--RVLLKVNSFDPAAAKATVSCQTA---NCIIQPVKIINRKDQNAPLIL-SRDQEV
TLNV

PF02010 // ENSGT00700000104221_2_Domain_0 (305, 788)

TIRWHCPDALVVRKTWLYFSVASVND-TPDWNRPVQLPHVQV-TKVSFLHIPKYAL
PYGVYVFNFTLSLVRW-DPVLPTVTDSDIIYIWVKKRPLKAVL-PGASRVTVRFSDALIL
NGSMSYDPEA---DIPTE--GLIFFWYCTTNPRYYSDNYMLVTNRDVCHP-KQDSLDWPW
AVGPVLTIPAETLRGNGVYYFRMVVQKQNRTAFSDKTVHVLQGLQPKAHISCIENCGHTL
AVSDRFSLFLNCSSCGS-R-DFYSWSILSRMGKEVMFDWAGQAVTRRDGAYLSMKAFAFR
DFLENRFWVSLILKSWSGVIMTLRHPVVINQGPQVGKCNIDPASGISMVTKFAVACSGFK
DKNLPLTYKVIV-SEL-DSIGDISSVDENTLGTIMYLGTQPTTPAFFLPVGMATNHYNLR
LYAQVYD-SLGTFSQVTLQATVKAPTVRDSSKNVVQQLLNVTQL-NS-SLSTLLQKQDWL
PAGYLVY

ENSGT00700000104221_2_Linker_0_1 (788, 1329)

VVTSVFNNIKWELELQGDRTRVLEYLVNQSFMLAMRTMDEICQSVMVITKLTQ
KALDLSQPTSEATTLLLRQANQALQAYQQENKHLHSQQIEILCTGILTSLSNLLKLA---
--KT-YHTSETLLFIMQSLSDMILANMVPGSKT-VLRTSNFNMYVEKVENWNVH-QAFRN
ESRCS-NCLRATLNTSTVPGLPAKAPVSVMFCKFVDDPFPWLTYPE--NISTDVVGFRMT
GAADNGNAIEIAPDTAEVYLVRKDLTSSSFNLTVGPGIK---SAGFSKMTTGGISFEVDG
RGFGEVLIHIVTNVTVLFEALVYEGIQLIPTNLMAIFLVPHDIPPIAKW--SGLFDPNCS
V--KEARVVCLSSTLLRTIAQRR-HSFKYNISVVLQASRFVFKPTNKLVRIALFMVHCLD
MYGIQSDWGQSTCVLGERTTWKTIHCICR-KARRSRRQL-----T--YSYMHIHFVTAKV
IVVPNPVDLRLQVISNVTQNPVTLLAVLCIMIVYVILASWALHRDVIDQYLHDNVVILTD
NDPFDTIC

PF01477 // ENSGT00700000104221_2_Domain_1 (1329, 1436)

YLVTIFTGSRWGSGTKANVFIQLMGTEGTSDAHCLTHPYFQTLYRGSRNTFL
LTTKNDLGDIHSIH-VWHDNSGKAPSWYLSRVKVENLFSKRIWLFVC-RRWLSVD

ENSGT00700000104221_2_Linker_1_2 (1436, 1927)

T---T
LEETFPVTHPDESLKKTDFFMIDLNDKLGKNHMWFSIFTDIVPKPFNRLQRLSCCLAMLL
SSLVCNIMFFNLNITKQP-ESRQGHIIRSMVIGVESALITFPVQLLITFFFTYSQKK-PK
VDTDKVAPQKHPLMS-EEGLSWKDRLKKWHEYEMKTLTSKAANPASAPEEKDAN------
----------------------------------------KASK---------TSQAPDT
QTSNKN--FSNNNLEDSKDVPP---KASST--------Q-LHATRSVK--KTQIILPRRC
VYIAWFLVFATSGVSSFFIVFYGLTYGYDKSVEWLFASFCSFCQSVFLVQPCHILLRSGT
R---MHRPKYCKN--LSWSSKYHY--TEIRLQEL---KMTPEETEQ--LHEDMA--YIRS
LSIYQPITEDKIQIFRRKNRIRKRSFLFLSYLVTHFIFLTLLLLLIFPLRHNDSFYYNQF
VRHRFS

PF08016 // ENSGT00700000104221_2_Domain_2 (1927, 2365)

MD-LATVVKLGDIYAWLNGV--FLPLLHNDKSPTFLPDSSSKILGLPLMRQVRA
KPSNKTCLLAKKFAQSRIAGELHCHPQYGIDPEDTRHYPGVWNKAGKRSIDKT---SNGF
TYKPPGRKWVYYSYGVLNTYGSGGYEFYFFPEQQMFNSTLRLKELEGKNWLDELTWAVIV
ELTTLNPDTSLMCSISVVFEVSPLGVVNSSLSVYSFPLADFNSRSS---AEIYLYVAILI
FFCAYVVDEGYIIMQERASYIRSMYNLLNFSLKCMFALLIVLFFQKHLLATKLVRLYNTD
PEAFIPFHAVSRVDHFMRIILAFLLFLTILKTLRYSRFFYNVRLAQKTIQAAFPGICHTA
LVVSIYSFMYVAFGYLVFGQHEWNYSNMIHATQTIFSYCVSAFQNTEFSGNKILGVLFLS
SFMLVMICIFINLFQVVILSAYDEMKQPVYEEPSDEAEAVTYLCDSLKSGFDFLTSGPQD
KDQSDFFEDMLYGQPEKNTRRFLGLKARNINGKKMIYLVV

MWPGPALLLL----------GLGLGLGSQPPPTGPRGLPGVLRGAPGLGQD---------
------TESSV-------------RGSD------------------TGG------LS---
-------------------PRA-AP-----------------------------------
--------------------------------------RR---------ASPTLPHRCPS
GAAA--RVLLKVNSSDPAANKATVSCQRV---TCIIQPVKI-NRKDQNAPLIL-SRDEEA
TLNV

PF02010 // ENSGT00700000104221_2_Domain_0 (305, 788)

TVRYHCPGALVIRKTWAYFSVASVND-TPDWNRPVLLPQVSV-SKGFSLHIPKYAL
PYGVYVFNFTLSIFRW-DPSWPTARGSDIIYIWVKKRPLKAVL-LGAPRVTMKFSDELIL
NGSMSHDPEA---DIPTW--GLQFFWYCTTNPRYYSGNYVLVINQDVCHP-EQDSLNWPW
AVGSVLTIPPKTLRGNGVYYFRMVVQKQNRTAFSDKIVHVLQGLQPKVHISCIENCGPML
AVSDRFSLFLNCPSCGH-Q-DSYSWSILSLMGHEVMFDWAGQAITRRNGAYLSIKAFAFR
NFLENRFWVSLILKSWGGVTTTLRHPIVINHGPQVGKCKINPASGISMVTKFAVECSDFK
DKNLPLKYKIIV-SEL-DSIGEISSVEENTLGSVVYSGTEPTSPAFFLPVGTVTDQYNVR
LYVQVYD-SLGTFSQVTLQATVKAPTVRDSSKNVLQQLLKVTMEPTS-LLSTLLQKQDWL
QAGYLIY

ENSGT00700000104221_2_Linker_0_1 (788, 1329)

VVTSVLNNIKGELELQDDRARLLEHLVQQSLTFAMNTEDEIGQSVMVITKLTQ
KASDLSQADLEAITFRLRQASQDLQAYQHRHKHLHSRQVEVVSTGILTSLSNVLKLI---
--NP-YYTLQDPLFVVESLSDTILDNKLPGSKTTALRTSNFNMYVEKVENWNVF-KAFRN
DSLCP-NCLRATLNASAVPGLPPKAPISMMFCEFTEDPFPWLTYPE--NSSVDVVGFRMT
GVADNGKVIEITPDVAEVYLVRKDLTPSSFNLTVGPGIK---SDGFSKMTTGGISFEVDS
RWTGELLIHIVTNVTVLFEALVYEGHQLTPANLMASFLVPHDTSPTVKW--RGLFDPTCS
V--KEARVVCLSSSLLRSISQRR-LSFKYNISVVLQASRFVLKPTNKLVRIALFMVHCLD
MYGIQSDWQQSTCVLGEKTTWKTVHCICR-NGRRSRRQLTSAKLT--YHHLHTHFVTAKV
IVVPNPVDLRLAVISNLTQNPATFLAVLFIMILYVILAFWALHRDVIDLYLRDHVIILTD
NDPFDTLC

PF01477 // ENSGT00700000104221_2_Domain_1 (1329, 1436)

YLVTIFTGSRWGSGTRANVFIQLMGTESTSDVHCLSHPYFKTLYRGSINTFL
LTTKNDLGDIHSIR-VWHDNSGKAPSWYLSRIKVENLFNKRIWLFVC-RRWLSVD

ENSGT00700000104221_2_Linker_1_2 (1436, 1927)

T---T
LDATFSVTNPDEPLKKTDFFMIDVRDNLGKNHMWFSIFTDIVPKPFNRLQRLSCCLAVLL
SSLVCNIMFFNLNQKEQI-ESSHMYIISSMVIGIESVLITIPVQLLITFFFTYSQKN-LK
LTLDKGAPQKHPLMS-EEGLSWKERLHKWHEYEMKALPRKAAVSTSASKKKEAS------
----------------------------------------ETSQ---------KHEKADT
QMSNKN--ISNNNLEASEGVPP---KASSS--------Q-MHTTESVKK-KTQIILPRWC
VYIGWFLVFATSGISSFFIVFYGLTYGYAKSIEWLFASFCSFCQSVFLIQPCKILLRSGT
R---SYKPKYCKN--LSWSSKYHY--SEIRLQEL---KMTREEMEQ--LHEDMA--YARS
LSVYQPITEDKIQILRRENRIRRRSFLFLSYLVTHFIFLTLLLLLIFSLRHNDSFYYNQF
IRHRFS

PF08016 // ENSGT00700000104221_2_Domain_2 (1927, 2365)

MD-LATVMKLGDIYIWLNGV--FLPLLHNDPNPTFLPDSSSKILGLPLMRQVRA
RPSNKTCLLAKKFVQSSIAGEIHCHPRYGIDPEDTQHYFSVWSKAGKQSTDKA---SNGF
TYKPPGKKWVYYSYGVLNTYGSGGYAFYFFPEQQMFNSTVRLQELEGKNWLDELTWAVIV
ELTTLNPDTSLMCSISVVFEVSPLGVVNSSLSVYSFSLADFNRKTS---SEIYLYAAILI
FFCAYVVDEGYIIRQEMAYYIRSVYNLLNFSLKCMFTLLIVLFFWKYLLATKMVQLYLAD
PEAFVPFHAVSRVDHFLRIILAFLLFLTILKTLRYSRFFYNVRLAQKAIQASLPGICHTA
LVVSIYSFMYVAFGYVVFGQHEWNYSSMIHATQTIFSYCVSAFQNTEFSGNKVLGVLFLS
SFMLVMICIFINLFQAVILSAYDEMKQPVYEEPSDEAEAVTYLCSRLKSGFDFLIARSRD
KDQSDFFVDMLYGQPEKNSRRFLGLKARNINGQKMIYLVV

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------ADVFLARKG-GVTAFNLVMGPDKT------ETYT-IGGFSFEVN-
KTSTSIYFQIMTELQVTFKVLVFTGTNLTHAQPVALFTAFHDMPTVASG--NGTATTDCS
V--TGPYIVCLPQSLLTIIVQES-GTDSQNISIILKTHYILRYPNRKLVDIYIFNDCCLY
LDGIESQWNKDTCRLGSFTNWQKIHCVCDSKK-TRQRLPPLP-------SANIKFLAAKV
VVLPNTVDLGRNLIADIPKNPLTLITVLSIFAIYLFLCCWAIGRDRAEKEI-KYIIVLPD
NEVSDQGS

PF01477 // ENSGT00700000104221_2_Domain_1 (1329, 1439)

FLVTLYTGSRWNAGTTVEVFLQLIGQYGRSKFRCLWHQPSPAFQRGSIDCFL
ITTKKNLGDIRSFR-VRLNDEDKSPTWFLSRAEVEDVSTRKAWFFLC-RKWIFLDKKNPS
RDWKFSVTDPEIPLPKLDYFLINFNRRLTEYHLWLSIFAPVIAGAFTRFQRLSTFLAVIL
FSLLVNIMFFNAEKDDE--APIYLRYLRSITVGIECALLTLPVEMLIIALFKYSQKDP--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------ESSVSCQRS---RCVIEKVKI-TKPSVPQPIFSVDQHLPY
TLFS

PF02010 // ENSGT00700000104221_2_Domain_0 (305, 787)

RVAVDCPGALSVNLTWRVFSVQNLST-DPSDAEPLDTSSWDN-RNSSIFYLPAYTL
RLGTYLFNLTVTVIPP-EKGAPLLEDSDFVFVDIQGRDLKAVI-AGGSKRTVGVDDTWTL
DGSASMDLDA---VDPSA--GLSFTWYCTTKASNLKKMPVPGPGRETCLS-SQVDLRWIW
PSDPVQTVLPRTLQSGRAYYFRLVVQKDRSTALADQTVIVQSGSTPEVSLNCIENCAKTL
IPTNRFSLAVNCSNCDKVR-PAYLWSLLSSEGTEIRFDWLAKTSTGRRGAYLTIKSLAFA
DSVDLSYILSLRTTSQSGVSSVSNYSFFVNSAPRAGRCLVSPLRGLAFLTKFIIQCRGFT
DDNLPLSYKMIA-SDL-TPVGTITTVEENTLGTVLYSGPWPTMPPSFLPVGVPSRQFTVT
IHVQVSD-SLGAFTQVTLHATVQPLTKRQSPETVLDEVHGATHGANA-TLTTLLRSGDFV
RAGNLI

ENSGT00700000104221_2_Linker_0_1 (787, 1327)

YTASTVINHIADAPGLRASKARLRTSLLNKTAGLPTSSLTEMNQIVSSVTQLTQ
KAAEISEESRTIASRRLAEVSRVLQDYRQKEKTFHSEEIDILSTGILASTRNVLRANLSA
ASGPNEEVVGRALSVLDTLADTVLLNKMPGENQTVMRAGTWTIHLWKDEKRDLS-SGASR
QEGCR-NCFYPTLGEESGAALPSGAHVSTVFYEFEEDPFRGLDRGDPRVPSTAVVGLKMT
GAGADGEAVRVVPRQVEFIVARKDSNSAFFNLTVGPHKR------LRRTTTGGFNFEMN-
RDYEELSVQIVTRVKTSFAILLYLGRNVSAPPL-TRFLAPPDRPPSILG--SGSPSPNCT
I--RAPYVLCLPRSLLEALVPGL-RSPNWNLSVVLRARRFVRRRDRRLVTISLFVAHCLA
KEGPERQWREDACLLGRRTDWRQVHCLCQ-PQGKVERRAVTAGPSRRTLAHKTLFLAGRL
IVPPNPVDLEQDLIAALQKNVVTLLAVLVITLVYIALAFWAINRDIADRLLRERVVVLPD
NDPFDK

PF01477 // ENSGT00700000104221_2_Domain_1 (1327, 1435)

VCYLVSVYTGSRAGAGTTADVFVQIIGTQGASEAHCLRHPDYRPFLRGRADSFL
LTTRRDLGDVYSLR-VWHNNRGGSPHWYLSRVKVENLFTKQAWHFIC-RQWLAV

ENSGT00700000104221_2_Linker_1_2 (1435, 1927)

DKGDRL
LERSFVATHPEVPLARTDFFLIEVAGRLAGDHIWFSVFVEAVPGQFGRLQRLSCCLAVLL
STLLSNIMFFNIDENQEA-VAEDRQYLRSLMIGIESVLITMPVQMVISTLFASSQAP--P
VAPEPVEPPGAPPPPAAQFRTWKEHLQSWYTPEPAPAAPADGAPPPAPAGA---------
-GPPPGRQK-------------------------------------------SNCAVPEA
-----TAN-AIAESEDGTGAAR-----GPA--------T-PPPAFCPCR-PPELVFHWWC
VYVAWGLVILTSCLSSFFIILYGLSYGYRTSLEWLLASASSFGQSVFLIQPFRILTLCAA
R---TAVPKLTRH--ISWTGKFNY--QEIQLEGV---PADADEQRE--AHRQAV--RARN
SREYRPLEEDEIRIIQKRKRIETQASSFLKDFVGHFVFLALIVNIVSSLENTNSFHSNQV
LARKFS

PF08016 // ENSGT00700000104221_2_Domain_2 (1927, 2365)

VN-LSAVSKLEHVYGWLDGV--LVPLLHHDHHPGWLADSWSKILGWPRMRQVRA
RPGPVSCFSPF---RRTTGPGPRCLPRFGRDPEDTRSYSDSWAEGGRP----G---GPSF
TYQADRNHWAYQSTGVLRHYGPGGYPFYFFPEELQFNSSTRLQELRQRGWLDERTWAVIV
ELTTLNPDVSLFGCVSVVFEASPLGVVNASLTVHSFTLPLFHKQSR---VQLLAYVALLV
FLCVYLLDEIHVVRREKAAYVRRTSNLINFVLKSAFLLFFLFYVAKFRLAHEIVALYLLN
PHSFVPFHSVAHVDQTVRVTLGFLVFMTVLKTLEYSRFFYDVRLAQRSILAALPGICSMA
LVVAVYFFVYMAFGYLVFGQYEWNYNSMVHSAQTVFSYCVSAFRDTAFSSNRLLGGLFLA
SFMLVMICVLINLFQAVILSAYEDMKQPVYEEPSDEAEAMNYLVHRLRRLYHRLTRRSPR
PEDTEFWDNVFYGQPKRRSRRYLGLKTRKINGKKMVYLVV

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------VSCQSN---LCK-VRVRI-NKHIPGRSVEQ-SREAPI
DLNS

PF02010 // ENSGT00700000104221_2_Domain_0 (305, 788)

TVQVYCPDYTTFHQYWQIFSVPSVQD-QPDWDQPIHNPYLDQARGSDFLHIPGSYL
PWGVYVFNVTVEILAKEDHKRTTVTGSDSIYISLLRRDLKAVL-LGDANLTVQFSDKVVL
DGTKSSDPDS---RRPID--PQHFSWYCTTHLGNYAGGQVAVTAKGVCHP-EQASLKWPW
ASGRVLTLSPETLKGDAVYHFRMVIRKGDRRAFSDKTIRVLRGPTPTAHISCLENCDNTL
VLSDRFSLFVNCTTCWS-L-DVYTWSILSSSGDEIPFDWMGQTVTGRNNVYLSIKTFAFG
NFLEATFWVSLSLASWSGATLDLKHSFLIHHGPQFGECKINPTRGLAMVTKFVVECSNIK
TKHTPLTYKIIV-SDL-DGVAEISSVRENTLGAILYWGTEPVTPPSYLPMGMLANNFTIK
IFARVYD-NLHTFSQMTLYATVRGPLDKFSPKTVLNQLLNITRGPTS-LLSSLLQKQNWL
PAGYLMY

ENSGT00700000104221_2_Linker_0_1 (788, 1329)

AAASVLNNMRKEATLKESKADLRAHLINQSFELPTSTLDEINQVVVLFTKLTR
RASEFTRGAQDRALERVGQASQALQEYQRKAKHFHSEQIEILSTGVVTSLSNILQQM---
--NR-FEVVEDPFYVLESLSDLILATKVPGNETTTLKTSSFNLYLAKVEKQDVT-RAFRN
EKHCP-HCLHATLNVSRIPSLPAKAPISIMFFEFAEDPFPWLSSPG--NISTEVAGFRMT
GSMKNGSVLEVTPDVAEVFLLRKNLASATFNLTMGPSNE---IDGVSRVTTGAFSFAVDS
REVKEVLVHIVTEVTLLFHVLVYAGSQLAPTHLAATFLVPPDMPPVIKQ--HDLFDPTCA
V--KEARVICLSPSLLQLLAQYS-RSPNYTISLLLKAPRFVLEPSNQLVRMSVFTVRCLN
MDGIQ-EWREGACVIGEKTTWDKVHCVCR-SLGRSRRQLGSIKLV--YRHLHTHYVTANV
IVAPNPVDLRLIVIRNLNQNPVTLLVVLFIMLVYIVLAFWALHRDAMDQFLRDHVIILPD
NDPYDNIC

PF01477 // ENSGT00700000104221_2_Domain_1 (1329, 1441)

YLVTVFTGSRCGSGTRADVFVQLRGTESTSDVHCLSHPYFTTLYAGSINTFL
LTTKSDLGDIHSIR-VWHNNEGKAPSWYLSRIKVENVFSRHIWLFMC-RVWLSVDT---T

ENSGT00700000104221_2_Linker_1_2 (1441, 1927)

LDQTFHVIRPDEPLSRLDFFLIDVNRKLGRNHMWFSVFAGIVAKPFNRLQRLSCCLAMLL
SSLLCNIMFFNLNKQEHA-EMPERRYIRSMMIGIESVLITIPVQLLITFFFTYSQRS-PQ
VRLEEVAPQKQPFLTMREGEHWREHLDKWHTHETTKTQAGESW----------R------
--RSSRLSKDSLK---------------------------EVLET-KPWRNRAEAQDSL-
-------DESDSFEEDSRGALS-----RKR--------S-LPEDMKFEK-KPRIVLPWWC
VYVAWFLVFLTSGVSSFFIVFYGLTYGYNKSIEWLFASVCSFCQSIFLVQPMKILLMSGF
R---TNRLKYSKN--LSWSSKYRY--TEILLQQV---QLSSEEMEQ--LHQRIT--HIRG
SRMYQPLTEDEIRIFQRKKRIKRRALLFLSYILTHFIFLALLLLLILLLHHTDSYYYNQF
IRTHFS

PF08016 // ENSGT00700000104221_2_Domain_2 (1927, 2365)

VG-LTGVTKLNDIYRWLSSV--LLPLLHNEQKPTFLLDSSSKILGLPLMRQVRA
KPHHKKCPPAQILVQNGIAGEIHCHPEYGIDTEDTKSYSSYWKGEGDPPTDKN---TNGF
TYKPPGKKWAYYSYGVFNTYESGGYVFYFFPEKQQFNSSLRLKELQEKNWLDERTWAVMV
DLTTFNPDAGLLCSISVVFEVSQLGVVNSSLSVYSFSLADFNIETS---AEIYLYMAILI
FFLAYVVDEGYVITQERASYIRSVYNLLNFALKCIFTVLIVLFLWKHFLAVSMIRFYLAD
PENFIPFHAVSEVDHIVRVTLAFLLFLTILKTLRYSRFFYDVRLAQRAVQAALPGLCHMA
LVVSVYLFVYMAFGYLVFGQHEWNYSNLVHATQTIFSYCVSAFQNTEFSSNRALGVLFLS
SFMLVMICILINLFQAVILSAYEEMKQPVYEEPSDEVEAIAYLCGKLRTTFSFLTSPSRA
KDEPDFFDDMLYGQPEKNSRRYLGLKTRNINGKKMVYLVV

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------RRAAPAFHPEEEAGLVAEGSGAP
RGLVPGLLRLAVSNSTPGTVEMAVLRQAA---ACKLHSVVI-QKP-LHTSVIHQKRGMTF

PF02010 // ENSGT00700000104221_2_Domain_0 (301, 860)

YLYARVLVDCSLSLSIKPEWIFYAVPDMKT-NPDWEKPLNVSFLHGVD-TVQLTVPGCTL
NYGMYQVYFTARVDVL--GTKRHFSRTDRVFLQIERSDLVANI-AGGTYRTVGFSDRWTL
DGSASYDPDS---QEPLE--GIAFTWYCTKKVSDYET--MQVSAGQKCHR-SQRDLKWPT
PTGSVQAVPPEFLPGNAAYHFRLVIQKDSRKSYAKQTVDVRPGSPPLLAVACLENCGGTV
IPTERFTLSGKCLNCPTKSQPVYLWSLCLENSTEIRFDWSSRTSTGRSGPFLSIHALTFT
NAAHQSYMLLLKVTTRGGGSALYRYTFRVNSPPRAGTCSISPHRGTAFQTKFVVQCNGFS
DSNLPLTYKVMVASDV-SQTAKISSVEENTFGIILYVGYQPRTPPSFLPVGMPSRKSTLT
LYVQVSD-SLGAFTQVSLYIRVENPVKSRPLAVIFHEMLASVSGLSA-PMTAYLQTGDYF
NAGYLAYLAASVLNYIKAAPTIQIPKAQFRESLIKTAVNISVESTMEINQVVASLSQVTE
EPEEVNIRSQEIAITKLTE

ENSGT00700000104221_2_Linker_0_1 (860, 1327)

VTRVLKV--QRNESHWSEQTEIQTSGILRCLSNILRAALLP
RRNVNVGGVTQVFSIMENLTEIVFQGKVPGETDTVMETKNWNITLKKDENWNVT-NAFSA
TETCR-NCFYPTLQKGQNSSLPRNAVISTAVFEFDENPFPWLGYTS--EIATTVLGFKMA
ETKANGDLQGILPEEADILITRKDTESATFRLAVGPDRT------ETYT-TGGFSLEVN-
RNTKIIYIQILTKLKVTFQVVVFTGTNVTQAFPIASFDAFPDMPTVASK--TKTANADCN
I--KAPYVICLPESQLKAAAQGS-GADSQNISIVLLTPYLTRYPTTGLVSVNIFSDQCLF
LGGVQSQWREDLCRLGPLTDWQGVHCICKMKQ-SHRSLSVRVASN--TSTFDIRFLAAKV
IVTPNTVDLEKTLIADIPKNPVTLLTVLFIFAVYLLLSLWAIQKDRADRASKDKIIVLPD
NDPLDK

PF01477 // ENSGT00700000104221_2_Domain_1 (1327, 1446)

ESFLVTLYTGSRWGAGTKADVFLQLIGQNGTSDVHCLRHPQVPSFRRGSTDRFL
LTSREDLGDICAFR-VWHSNRGPSPGWFLSRAKVENTSTRKTWLFMC-RKWLSLDKGDGL
LERTF

ENSGT00700000104221_2_Linker_1_2 (1446, 1926)

FVTNPNDPLPRKDYFLIRLSNGLTEGHLWLSIFAHVLNGTFTRLQRLSSCLTILL
LNLLVNIMFFNADKEEQ--SPIHLRYLRSIIIGIECALVTIPVEMLIIALFKYSQKDP--
--------TGSPPLLPGRLENGKEPLQKRYLPETSAQSRPQQCTGP-TASPKDE------
--QSRSSPELEPLPH--------------NSP------------PKAQALQ-------RG
LPPNSSFNK--NSA-EEG--GN----------FLKESKPLSVTSRPFRK-MPQVVFCWWC
VYLSWALVIAVTGVSSFFIVLYGLSYGYQTSMEWLLASAASFIQNVFFLSVLKIVCYSAL
N---TVRPKYCAN--IPWLTQENY--SEIKLDKE---TLSEDEMRE--KHFKLA--QIRG
TKQYKPLEADEIAKMLKRAKIKAKAFVFIRDFMIHLVFLALVLHFAYSSENDNIFHNNQF
IQNQF

PF08016 // ENSGT00700000104221_2_Domain_2 (1926, 2365)

SPR-LSPVDKIEDIYMWMNDV--FLPLIHNNVQPSFLPESWSKIIGLPRMRQIRA
KQTEKKCFHPHSFVNKLVISESHCLHKYGRDTEEKGDYAGSWSKIPNQSVSKDASSWLGF
TYQPNKTPWSYYSFGNLHTYGSGGYTFYFFPEEGRHNSTARLDLLQKSHWIDENTWALII
ELTTFNSDVQLFCSISVIFELSHLGIIKPSLSVHSFALPIFHQQTK---GQQLLFVVFVA
FLFIYIADGLYIIVQG-KKYTNSPSN-----SKSAFFLFVPLKVLKFKMGADILKFYLLH
PNDFIPFHAVSHVDQILRITTGFLAFFVVLRTLKYSQFFYDVRLAQRSIMAVLPGIFSLA
FVVVVYLFVFMAFGYLAFGQHEENYNSMIRSAQTIFSYSVLAFRDTDFRSNRFLGGLFLA
SFMFVMICLLINLFQAVILSAYRDTKQPVYEEPSDEAQAVDFLLQRLRKILCYLICRTAK
TGEPNLFHSMLYGQPQKRRLQHLGLKNRKINGKKMVYLVI

MWPGPALLLL----------GLGLGLGSQPPPTGPRGLPGVLRGAPGLGQG---------
------AESSV-------------RGGD------------------TGG------LS---
-------------------PRA-AP-----------------------------------
--------------------------------------RH---------ASPTPPRRCPS
GAAA--RVPLKVNSSDPVASKANVSCQTA---PCIMQLVKI-NRKDQNAPLIL-SRDEEA
TLNI

PF02010 // ENSGT00700000104221_2_Domain_0 (305, 788)

TVRWYCPDALVIRKSWVYFSVASVND-TPDWNRPVLLPQVAV-SKSFSLHIPKYAL
PYGVYVFNFTLSIFRW-DLAWPTVTGSDIIYIWVKKRPLKAVL-LGAPRVTMKFSDELTL
NGSVSYDPEA---DIPTW--GLQFFWYCTTNPRYYSGNYVLVINQAVCHP-EQDSLNWPW
AVGSVLTIPPKTLRGNGVYYFRMVVQKQNRTAFSDKTVHVLQGLQPKAHISCIENCGRTL
AVSDRFSLFLNCPSCGR-Q-DLYSWSILSLTGHEVMFDWAGQAITRRNGPYLSIKAFAFR
NFLENRVWVSLILKSWSGVTTTLRHPVVINHGPQAGKCKINPASGISMVTKFAVECSDFK
DENLPLRYKIIV-SEL-DSIGAISSVEENTLGSVVYSGTEPTTPAFFLPVGMVTDQYNVR
LYVQVYD-SLGTFSQVTLQATVTAPTIRDSSEDVLQQLLNVTMEPTS-PLSTLLQKQDWL
EAGYLIY

ENSGT00700000104221_2_Linker_0_1 (788, 1329)

VVISVLHNIKGEQELQDDRARLLEHLVKQSLTFAMNTADEIGQSVMVITKLTQ
KASDLSQADLEATSFRLKQASQDLQAYQQRHKHLHSWQVEVVGTGILTSLSNLLKLI---
--NP-YYTLQDPLFVVESLSDTILANKVPGSKTTALRTSNFNMYVEKVENWNVF-KAFRN
DSLCP-NCLRATLNASTVPELPPKALISMMFCEFTEDPFPWLTYPE--NISVDVVGFRMT
GVADNNQVIEITPDIAEVYLARKDLTPSSFNLTVGPGIK---SDGFSKVTTGGISFEVDS
RWTGELLIHIVTNVTVLFEALVYEGHQLTPTNLMATFLVPHDIPPIVKW--SGLFDPTCS
V--KEARVVCLSSSLLRSIAQRR-FSFKYNISMVLQASRFVLKPTDKLVRIALFMVHCLD
MYGIQSDWQQSTCVLGEKTTWKTVHCICR-NGRRSRRQLTSVK-----HHLHTHFVTAKV
IVVPNPVDRRLAILSNLTQNPATFLAVLFIMILYAILAFWALHRDVIDLYFRDSVVILTD
NDPFDTLC

PF01477 // ENSGT00700000104221_2_Domain_1 (1329, 1436)

YLVTIFTGSRWGSGTRANVFIQLMGTESTSDVHCLSHPYFKTLYRGSINTFL
LTTKNDLGDIHSIR-VWHDNSGEAPSWYLSRIKVENLFSKRIWLFVC-RRWLSVD

ENSGT00700000104221_2_Linker_1_2 (1436, 1927)

T---T
LDATFSVTNPDEPLKRTDFFMIDVRDKLRKNHMWISIFTEIVPKPFNRLQRLSCCLAMLL
SSLVCNIMFFNLNQKEHS-ESRHMHLIRSMLIGIESVVITIPVQLLITFFFTYSQKN-LK
VNLDKVAPQKHPLLS-EEGLSWKERLHKWHEYEMKALPRRAAVSTSAPKEKEAF------
----------------------------------------ETSQ---------KHEKADT
QMSNKN--SSNNNLEASEGVPP---KPSSS--------Q-THTTESVQK-KTQIILPRWC
VYIAWFLVFATSGISSFFIVFYGLTYGYAKSIEWLFASFCSFCQSVFLVQPCNILLRSGT
R---SYKPKYCKN--LSWSSKYHY--SEIRLQGL---TMTQEEMEQ--LHEDIA--YVRS
LSMYQPITEDKIQILRRENRIRKRSYLFLSYLVTHFIFLTLLLLLIFSLRHNDSFYYNQF
IRHRFS

PF08016 // ENSGT00700000104221_2_Domain_2 (1927, 2365)

VD-LATVMKLGDIYTWLHGV--FLPLLHNGPNPTFLPDSSSKILGLPLMRQVRA
RPSNKTCLLAKKFVQSSVAGEIHCHPRYGIDPEDTQHYSSVWSKAGKQSTDKA---SNGF
TYKPPGKRWVYHSYGVLNTYRSGGYAFYFFPGQQMFNSTVRLKELEGKNWLDELTWAVIV
ELTTLNPDTSLMCSISVVFEVSPLGVVNSSLSVYSFSLADFNRKTS---SEIYLYAAILI
FFCAYVVDEGYIIRQERASYIRSVYNLLNFSLKCMFALLIVLFFWKYLLATKMVQLYLAD
PEAFVPFHAVSRVDHFMRIILAFLLFLTILKTLRYSRFFYNVRLAQKAIQAALPGICHTA
LVVSIYSFMYVAFGYLVFGQHEWNYSNMIHATQTIFSYCVSAFQNTEFSGNKVLGVLFLS
SFMLVMICIFINLFQAVILSAYDEMKQPVYEEPSDEAEAVTYLCNRLKSGFDFLTTRSRD
KDQSNFFVDMLYGQPEKNTRRFLGLKARNINGKKMIYLVV

MRPGPALL-LL---------GLSLGQGCLRMTSVPGGVQAADSE---GPPSVLLVSDSDF
RGPGIGTHLCLRFHLSASHSLSIL--------------------------------HAVS
RGH-YLG--LHALL--R--ARAAAPS-----HLHLLLTAPKCHLLLAWFPPLQRPPRHPR
-------TFLLLLLRPCPARPGAP----AAQL------TWPAGAPGPPHRGFMAETKGPR
DSGP-KVILEKVNSHPRKAREPSVFCVVL--------HVTI-ERD---QPVKL-SRTEDN

PF02010 // ENSGT00700000104221_2_Domain_0 (301, 860)

TINASMVFSCPTR-VFEQWWEIFKVSG-EK-VPNWAKPLYIPQIYKRRNSSSLYIPKNTL
MWGLYVLRFRMVVITT-ITWSPIIDSDDHIYIEVYRRPLKAII-LGASDFTLKFTDELVL
NGEQSADLED---DNPQE--GLHFLWYCTTNPQNYVKSYINTSSSQTCHP-GQTDLRWTW
ATGPVLKTAPEMLKGDAEYFFRMVVEKKDRIAFADRSVRVLPGPTPIAGIECLENCGQLL
MISDRFSLFLNCTNCGSNWMNRYTWSVESADGRDVAFNWEEQTVTGRHGSYLSTKTYAFL
MFPEKHNWISLTLDTWSGVSLNFRYSFIVNHPPVFGTCEISPLKGITFVTKFVVSCHGYR
DRNMPLTYKVIV-SDL-YNLGEISTLEDNTLGAILYLGTRPSTPTFYLPVGIMANQFDVK
LYVQVYD-TLGSFSQVTLHATVQPPTNQQAPSTVIQQLLNDTKGTGS-LLLTLLQKQEFL
SVGYLMHTVASVLNSLRNDRTLTGDKNRLRNHLVNQTFRLPLTTLPEINQVVTIITELTQ
KISELTQVAQRLAIVRIWQ

ENSGT00700000104221_2_Linker_0_1 (860, 1327)

ATEALQAYQQNDKKFRSEQMEIVSSGIFTILSKILMQI---
--TP-HQVVQDPFYMIEALTDTMLGIKVPGSIATTLSISNLNVHVNKVELRDAH-RVYTN
EPHCQ-NCLYPALKAHSVPDLLPSAPISTMFCEFADDPFPWLTYSG--QISDQVIGYRMT
GTKANGDVVDVRPDVVEMYLRRRSLTSAAFNLTMGPTSEPDEVDESLEKTTGGFSFEVDT
GVVKELLIHIVTQVTVVFKVLVYAGSEVTPPALVASFLVPHDMPPTASP--SDLLDLTCS
V--KEARVLCLSQTLLLLIAQLI-HSPKCAVSVVLQAPRFVLTPSDRLVSISIFSVHCLD
MLGIQSDWREGNCNLGKKTNWHKVHCICK-VKGRARRQVSST--G--RIQLRTHFITAKV
IVIPNPVDLQLDVVKKISQNPVTLFTVLFILLIYIVLAFWALHRDETDQFQQHPVIVLPD
NDPYDN

PF01477 // ENSGT00700000104221_2_Domain_1 (1327, 1445)

KCYLITIFTGSRWGSGTRADVFIQLMGSQGTSDVHCLTHPDYKTLLRGCANTFL
LTTKSDLGDIHSIR-LWHNNEGKAPSWYVSRIKVENLFHRRIWLFMC-RKWLSLET---S
VDQT

ENSGT00700000104221_2_Linker_1_2 (1445, 1926)

FPVTNPEKPLNRIDFFLITSTYELGKSHMWFSIFAGIIAKPVNRLQRLSCCLAVLL
STLLCNIMFFNANRKEDI-ESKELYYIRLMMIGIESALITAPVQVLLSFLFTYSQKKPIE
MTVDEVAPRNDHPVVSEEGGFWDEHLVKWYAYETTKTKKRHAE------KLASS------
--GSPELQEAPGK---------------------------TTSKI-NHQLEVEESKAL-S
YKKNTNSNNKNADTTYNQDVRS---E------------E-LPSQEQPKR-KTRILLPRWC
VYIAWFLVFAICSISSFFIVFYGLTYGSNMSKQWFLTSVFSFFQSIFLVQTTKILLWTSF
R---TNKTQYCKG--LPWTVKYRF--TEIKLPGL---RKSKAEKHR--QHLHMR--RLRR
SKIYKPLTQVEIGIFKRKKRIKRRAFLFLSYLLMHFTFLALLLGLITRLHHADCFHYNQF
IRDYF

PF08016 // ENSGT00700000104221_2_Domain_2 (1926, 2365)

SVD-LTTVTKLEHIYTWLSKV--PLPLFHNDVHPTYIYDSSSQILGLPLMRQVRA
TPDAKRCLPDKNPVLNGIKNIMHCHPEYGVDPEDTKNYSSFWKDVGKQAVSTN---PNGF
TYKPQEKNWPYHSYGLLHTYGSGGYAFYFFPDQQQFNSTLRLKELQGNHWLDEKTWAVIL
ELTTFNPDVNLFCCVSIIFEVSQLGVVNSSASVHSFSLSDLNWNRS---AEIYLYLAVLI
FFLAYIIDEAYIIGLERASYVRSVYNLLNFVLKCIFTVLIVFFLRKLLLTTDIILFYLSS
PQNFIPFHAIAQVDHVVRILLGFLVFLTILKTLRYSRVFYDVRLAQRAIQIALPGITHMA
FVVSVYFFVYMAFGYLVFGQHEWNYCNLIHATQTVFSYCVSAFQNTKFSSNRVLGVLFLA
SFMLIISCILVNLFRAVILSAYEELKQPVYEEPSDEAEAMTYLCHKLRMLIRFLTCQPRT
KEEPEFVTDMLYGQPEKKNRQYLGLKTRLVNGKKVAYIVV

------------------------------------------------------------
----------------------------------------------PPPCASDAA-----
RTXVQVR--ARRAAANA--APAPAPA-----PVDLQLSAPGGRLSLRWLSRLPRS-----
LGPL-EWTFRLGLLGPAAAQSRAL-------------PRRALPRGRRSYPGFVARTECPT
DGPT-PVFLVAVGPNSSEPTESSVSCQVSGPMTCKLDPVRI-NRNDD-KPVRL-TRDMGD
TFNVTIIL

PF02010 // ENSGT00700000104221_2_Domain_0 (309, 788)

FCPVPEYYLRRWYIYPVPYVGA-VPDWTKPMQKPPVKVDRSATVLTILPYSF
TWGVYLFNFSVVVRTR-DPRVPGQKDSDSIYVVIFRRPLNAVI-SGPSNITINFTDGVTL
NGNKSSDPEE---TDPLEKERLKFLWYCTTNPKDYDGQKITVISKEVCLP-EQVDLKWTW
ASGPILTLSPETLQGGRVYFFRLVIQKTGRSAFADATLRVLQGE-PVASISCIENCDQVL
VLSERFSLSLDCTGCTAGR-DVYRWSILTSSGQEVPFDWTGQTSTGRHGAYVSIKAFAFW
SFKEDKFWISLNAATWSGVTLVLRYPFIIHHVPITIDCKIVPEKGISFITQFVVICTHFK
HKNIVLTYKIIV-PDV-HGFGEISSLKENNFGSIMYLGKNSTSPPSFLPVGVLDSHYALN
IIAQAYNTSLGAFSQVNLYATVRPPTDVKSSTTVLEELSNFTTGPNS-SLSTLLQQQDFL
NASYLIY

ENSGT00700000104221_2_Linker_0_1 (788, 1327)

VVASVMNSMKTDTSLQADKIKLREHLFNQTLILPINTLVNISQVVMTITKLTE
KTSEISAFSQKLATVRTWQASQALQDSHQRDKSISSEQIESVCTGILTTLSNILKLL---
--VH-YEVFEEPFHVVESLADTVLAVKVPENETTALRTSNFKMHVKKTEKWNVT-KFFST
QKHCQ-NCFYPTLNVNSVASLPANAPISTMFCEFADDPFPWLNHGE--NILTQVVGFRMT
GVEVTGDVIEMPPDAVEVYLIRKNLSFGTFNLTVGPSSEPYAVDESLAKTTGAFSFVVDS
AEGRDVLIHILTDVSVLFTVSVYAGREITPKSFMTSYLVPHKIPPIANE--SDLFDPECP
V--KEARVVCLPAALVQVIAQRT-SSSECTIAVVLQAPRFVLNPNNKLVRISVFSTECLD
MLGIQSDWREDTCVVGEKTTWQRVHCMCK-NPRRAKRQLDIIKQA--NLRLRTHYLTANV
IVVPNPVDLRVEAVKNVTQNPVTLFTVLLIMLLYLILAFWALHRDETDQYLREHVIVLLD
NDPDDN

PF01477 // ENSGT00700000104221_2_Domain_1 (1327, 1435)

VCYLVTVFTGSRCGSGTRANVFIQLHGTEGSSDVHCLSHPQFTTLYRGSICTFL
LATQKDLGDIHSLR-VWHNNEGRSPEWYLSRIKVENLFTRHIWLFMC-REWLSI

ENSGT00700000104221_2_Linker_1_2 (1435, 2158)

DT---S
LDRTFHVTPPDKPLKKMDFFLIDFSYKLGRSHLWFSVFSGVISTPFNRLQRLSCCLAMLL
STLLCNIMFFSLEKEIEA-EPQEQRYIRSMVIGLQSAFITLPVQLVITSLFIYSQRR-PR
VTLSEVTPRKHPLQR-PASEHWEERLGNWHAYETAKASSQEPVSKRHRAKPKAS--VNVT
SKRQPPAK------------------------------------A-QSKVTQAQSKFSHI
QGRN--INTNSRNIEDNTNVSD-----EHP--------P-QPGSRALKE-KTRIVLPQWC
VCVAWLLVFLTCAVSSFFIIFYGLTYGFEKSTAWLFASFCAFTQSVFLVQPSKVILVSGY
R---TRRAKYCKN--LSWIGNSRF--TEIKLHNI---RKDPEEMDR--RHRYVM--ELRN
SRMYQPLTQDEIMIFKRKKRVKRRAFLFLIYILTHFIFLALLLSLVAVLRPTDSFYYNQF
IRDQFSVD-LAGVARLEDIYQWLNRV--LLPLLHNDPNPTFFPDSSSKILGLPLMRQLRA
QPGEITCLPAKKFVAGSLKGEIRCHPEYGIDPEDTKNYSGSWNRVSKRDTDQM---AGGF
TYRPPEKRWAYSSYGLLHTYGSGGYAFYFFPAEQQFNSTLRLSKLQKGHWLDEKTWSVIV
ELTTFNADISLLCSVSVIFEVSQLGVVNTSLHAHSFLLAHFNRKYSADSAENYLYLA

PF00520 // ENSGT00700000104221_2_Domain_2 (2158, 2358)

IFI
FFLAYTVDEVYVITQERTAYVQSVYNLLNFALKCIFTLWIVLFFRKHFLAISVVRAYLSN
PEDFIPFHAVAQVDYTMRVILGFLVFLTILKTLRYSRVFYDVRLAQRAIQIALPGICHMA
LVVSVYFFVFMAFGYLVFGQHEWNYSDMIHATQTIFSYCVSAFENTEFFNNRVLGVLFLS
CFLLVMICILINLFRAVILSAYEEMKQPVYEEPSEEAEAMTYLCHRLRSAFCCLCFKPRA
EDEPRFFINMVYGQPEKKSRRYLGLKTRNINGKKMVYLVV