Query Results 

MLRLPKKGLPRFDQIQDEETYLENLSVQRNASVFFEKYDRSEVQELLTTALVSWLSAKDD
VRSQLDIPCGIMSQMNNVSFSTAILLTPVDPVALLDYREVHQIIRELAVGIYCFNQIPSI
SLEANYDQSSSCQLPPAYYDTRIGQILINIDYMLKALWHGIYMPKEKRARFSELWRTIMD
IDPDGKPQTNKDIFAEFSAAGLVDITKDPDFNGIYDEDMNEDPTYDPNSPEEKAVFMKYA
ENIMLKLTFSTIQVQQCENVFIFETAYWLTNAIKCNQDYLDICTYQRLQQRLYLQKKVIQ
KHFEKKTDLRKGIGYLKLICFLTPFLLSLKKKMKVPYLDSLLPLFS-DDKVKTERELPPF
IYGRDFKCQHFHYKEDQYFHVHGGIEFDISTPSVENALEDFKNNLEKIRDCAANTF----
VEDLGYKEHYSIPVMELNGKSYYVICFELETFYHQLYKTKWWGAINEIVNNLKPKRLPLT
DAQLHEQFKKKFGFKKAMKCKSIPFGMKSAVERGLSAVFHTFSRKTSSLTINISDEAGYA
IFHHAALHNRVSIICQLCNASFNVNQRRFVMSSQE--SSKMDVKKERNGPTP

PF12796 // ENSGT00680000100065_0_Domain_2 (593, 697)

LHLAAQAC
SLETTICLLCFKADYTLSEKRGWMPIHFAAFYDNIGIIIALCRKDPSLIE----------
AEATAENQCTPLLLAATSGALDTIQYLFSLGANWRKTDIKGNNIIHLSVLTFHTEVLKHI
IELNIPELPVWKTLVEMLQCESY-KRRMMAVMSLEVICLANAGYW

PF00514 // ENSGT00680000100065_0_Domain_5 (766, 800)

KYILDAGTIPALINL
LKCSKIKLQCKTVGLLSNISTHANIVHAIVEAGGIPALINLLVSDEPELHSRCAVILYDI
AQLE-NKDVIATCNGIPALISLLKLNTENVLVNVMNCIRVLCMGNEQNQRAVRDHKGIQY
LITFLSSDSDVLKAVSSATIAEVARDNREVQNAMASEGAIPPLVALFKRKHLSVQVKGAM
AVESLASYNPCIQREFLEKSLSKYLLKLLKAFQIDVKEQGAVALWALAGQTLKQQKYMAE
QIGYNFIINMLLSPSAKMQYV---GGEAVIALSKDSRMHQNQICEGNGIAPLVRLLRINK
IAEGTLLSVIRAVGSICIGVAHTS----NPISQQFVVEENAFPVLIHLLRNHPSPNIKVE
V----AFSLACIVLGNDLLQNELQENEGFKYADVLHLLHSQDKDVCLRAGYALTLFAFNN
RLQQYLILESGIMTVSIFEPFLESTIETEKAMAAFQIIILAKVIIDMDHITLSAR--GVT
ILVDSLYSVHSTTIVLTGNLIASL----AHSRAGIPEAFATLGTIQRLCYHLYSEKEEVR
TACSCALGYLTYNASAFRILLKECRNKPNQFLRLTNNISRDASINPAFLKEFQMQQ-RVG
LPALSLEK---NGGPSITPVFKKGK----EHRRKLKPKIQPRDSLTLIPPVTNLM----G
LFNTTKKTTVSHNV-FSFSSATSSDITE---------------VSRPRIVFLSQLGKHVQ
KANPEPTEG-------------------

MLRLPKKGLPRFEQVQDEETYLENLAIQRNASAFFEKYDRSEIQELLTTALVSWLSTKED
VRSQGDLPCGIMSQMNNVGFSTAILLTPVDPTALLDYREVHQMIRELAIGIYCLNQIPSI
SLEANYDQSSSCQLPPAYYDTRIGQILINIDYMLKALWHGIYMPKEKRARFSELWRTIMD
IDADGKPQTNKDIFSEFSSAGLTDITKDPDFNEIYDEDVNEDPTYDPNSPEETAVFMKYA
ENIMLKLTFSTTQVQQYENVFIFETGYWLTNAIKYNQDYLDICTYQRLQQRLYLQKKIIQ
KHFEKKKDIRRGIGYLKLICFLIPFLLSLKKKMKVPYLGSLLQPFS-DDKVKTERELPPF
IYGRDFKCQNFHYKENQYFHVHGGIEFDISTPSIENALEDFQKNLEKIRDCAANTF----
IEDSGYKEYYSIPVMEFHGKSYYVMYFELETFYQQLYKTQWWGAINEIMNNLRPKRLPLT
DAQLHEQFKKKFGFKRAMKCKSIPFGMKSAVERGLSAVFHTFSRKTSSSTINVSDEAGYT
I

PF12796 // ENSGT00680000100065_0_Domain_1 (542, 642)

FHHAALHNRVSIICQLCNANFKVNQRRFVTFG--------------QGPTPLHLAAQAC
SLETIVCLLCSKADYMLSEKRGWMPIHFAAFYDNICIIIALCRKDPSLLE----------
AEATAENQCTPLLLAATSGALDTIQYLFSIGANWRKTDTKGNNIIHLSVLTFHTEVLKYI
IKLNIPELPVWKTLVEMLQSESY-KRRMMAVMSLEVICLAN

PF00514 // ENSGT00680000100065_0_Domain_5 (762, 800)

DQYWRCILDAGTIPALINL
LKSSKIKLQCKTVGLLSNISTHKRAVRALVEAGGIPSLINLLVCDEPEVHSRCAVILYDI
AQCE-NKDVIAKYNGIPSLINLLNLNIENVLVNVMNCIRVLCIGNENNQRAVREHKGLPY
LIRFLSSDSDVLKAVSSAAIAEVGRDNKEIQDAIAMEGAIPPLVALFKGKQISVQMKGAM
AVESLASHNPLIQKAFLEKSLTKYLLKLLKAFQIDVKEQGAVALWALAGQTLKQQKYMAE
QIGYSFIINMLLSPSAKMQYV---GGEAVIALSKDSRMHQNQICEGNGIAPLVRLLRIST
IAEGTLLSVIRAVGSVCIGVAHTS----NPVSQQFVVDENAFPVLIQLLRNHPSPNIKVE
V----AFSLACIVLGNDVLQKDLHENEGFEYADVLYLLHSTEKDICLRAGYALTLFAFNN
RFQQYLILESGIMTISIFEPFLESIVETEKAMAAFQIVVLAKVIRDVDHITLSAR--GVT
ILVDSLYSVQTSTIVLTGNLIASL----AHSRAGIPEAFTTLGTIQRLCYHLYSGTEEVR
AACSSALGYLTYNANAFRILFKECRNKPNQFIRIKNNISRDASINPAFLKEFQMQQTLVG
LPSLSLEK---NGGPSIIPIFKKGK----DHRRKLKPKIQPRDSLTLLPPVTNFM----G
LFKATKKTKDSHNI-FSFSSTITSDITN---------------VSRPRIVCLNQLGKHVQ
KANPEPAEG-------------------

MLRLPKKGLPRIDQAQDEETYLENLAVQRNASAFFENYDRSEIQELLTTALASWLSTKED
GRSQIEFPSGIMSQMNNVGFSTAILLMPVDPTALLDYREVHQIIRELAVGIYCLNQIPSI
SLEANYDQSSSCQLPPAYFDTRVGQILIHIDYMLKALWHGIYMPKEKRVRFSEMWRTILD
IDPDGKPQTNKDIFAEFSSAGLVDITQDPDFSGIYDEDLNEDPTYYPNSPEEKAVFMKYA
ENILLKLTFSTTQVQQCENVFIFEATYWLTNAIKYTQDYLDICTYQRLQQRLYLQKKVIQ
KYFEKKKEIRRGISYLKLICFLVPFLLSLKKKMKVPYLNSLLQPFS-DDKVKTEREVPPF
IYGRDFKCQNFHYKENQYFHVHGGIEFDITTPSIENALDDFKTNLEKIRECAANTF----
AEDFGYKEYYSIPVMEFCGKSYYVIYFELEIFYQQLYKTQWWGAINEIVNTLRVKRLPLT
DAQLHEQFKKKFGFKKAMKCKSIPFGLKSAVERGLSAVFHTFSRKTSSSTINVSDEAGYA
IFHHAALHNRISIICHLCDANFNINQRRFVMFSQ--ESSKMEVKKERNGPTPLHLAAQAC
SLESTICLLSFKADFTLSEKRGWMPIHFAAFYDNISIIIVLYRKDPTLLE----------
AEATAENQCTPLLLAATSGALDTIQYLFSLGANWRKTDTKGNNIIHLSVLTFHTEVLKHI
IELNIPELPVWKTLVEMLQCENF-KRRMMAVMSLEVICLAN

PF00514 // ENSGT00680000100065_0_Domain_5 (762, 800)

DQYWKCILDAGTIPALINL
LKSPKIKLQCKTVGLLSNISTHVSVVHALVEAGAIPALINLLVSDEPELHCRCAVILYDI
AQYG-NKDIIAKFNGIPALINLLTLDMENVLVNVMNCIRVLCIGYENNQKAVRDHNGIKH
LIRFLSSDSDVLQAVSSATIAEVARGNKAVQDAIAQEGAIPPLVALFIGKQLSVQVKGAM
AVESLASYNPPIQKAFLEHKLTKYLLKLLKAFQVDIKEQGAIALWALAGQTLKQQKYMAE
QIGYNFIINMLLSPSAKMQYV---GGEAVIALSKDSRMHQNQICEGNGIAPLIRLLRIHK
IAEGTLLSVVRAVGSICIGVAHTS----NPISQQFIVDENAFPILMQLLRDHPSSNIKVE
V----AFSLACIVLRNDELQKQLQENEGFKYSDVLYLLHSTDKDICLRAAYALTLFAFNN
RFQQYLILESGKITLSIFEPFLQSTVETERSMAAFQIIVLAKVIIDVDHITLSAR--GVT
ILVNSLYSYKHTTIVLTGNLIASL----AHSRAGIPEAFITLGTIQRLCYHLYSGREEVR
TACSCALGYLTYNANGFRILLKECRNKPNQFLRIRNNISRDASINPAFLKEFQMQQ-MVG
LPSLSLER---NGGPFINPVFRKGKE----HRRKAKPKIQPRDSLTLMPPVTNFA----G
LFKTTKKSKIS-HNIFAFSSAISSDIIN---------------VIRPRIVCLNRLGKQEQ
KANPEPAEG-------------------

MLRLPKKGLPRFEQVQDEETYLENLAIQRNASAFFEKYDRSEIQELLTTALVSWLSAKED
VRSQGDLPCGIISQMNNVGFSTAILLTPVDPTALLDYREVHQMIRELAIGIYCLNQIPSI
SLEANYDQSSSCQLPPAYYDTRIGQILINIDYMLKALWHGIYMPKEKRARFSELWRTIMD
IDADGKPQTNKDIFSEFSSAGLTDITKDPDFNEIYDEDVNEDPTYDPNSPEETAVFMKYA
ENIMLKLTFSTTQVQQYENVFIFETGYWLTNAIKYNQDYLDICTYQRLQQRLYLQKKIIQ
KHFEKKKDIRRGIGYLKLICFLIPFLLSLKKKMKVPYLGSLLQPFS-DDKVKTERELPPF
IYGRDFKCQNFHYKENQYFHVHGGIEFDISTPSIENALEDFQKNLEKIRDCAANTF----
IEDSGYKEYYSIPVMEFHGKSYYVMYFELETFYQQLYKTQWWGAINEIMNNLRPKRLPLT
DAQLHEQFKKKFGFKRAMKCKSIPFGMKSAVERGLSAVFHTFSRKTSSSTINVSDEAGYT
IFHHAALHNRVFIICQLCNANFKVNQRRFVTFG--------------QGPTPLHLAAQAC
SLETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLE----------
AEATAENQCTPLLLAATSGALDTIQYLFSIGANWRKTDTKGNNIIHLSVLTFHTEVLKYI
IKLNIPELPVWKTLVEMLQSESY-KRRMMAVMSLEVICLAN

PF00514 // ENSGT00680000100065_0_Domain_5 (762, 800)

DQYWRCILDAGTIPALINL
LKSSKIKLQCKTVGLLSNISTHKRAVHALVEAGGIPSLINLLVCDEPEVQSRCAVILYDI
AQCE-NKDVIAKYNGIPSLINLLNLNIENVLVNVMNCIRVLCIGNENNQRAVREHKGLPY
LIRFLSSDSDVLKAVSSAAIAEVGRDNKEIQDAIAMEGAIPPLVALFKGKQISVQMKGAM
AVESLASHNPLIQKAFLEKSLTKYLLKLLKAFQIDVKEQGAIALWALAGQTLKQQKYMAE
QIGYSFIINMLLSPSAKMQYV---GGEAVIALSKDSRMHQNQICEGNGIAPLVRLLRIST
IAEGTLLSVIRAVGSICIGVAHTS----NPVSQQFVVDENAFPVLIQLLRNHPSPNIKVE
V----AFSLACIVLGNDVLQKDLHENEGFEYADVLYLLHSTEKDICLRAGYALTLFAFNN
RFQQYLILESGIMTISIFEPFLESTVETEKAMAAFQIVVLAKVIRDVDHITLSAR--GVT
ILVDSLYSVQTSTIVLTGNLIASL----AHSRAGIPEAFTTLGTIQRLCYHLYSGTEEVR
AACSSALGYLTYNANAFRILLKECRNKPNQFIRIKNNISRDASINPAFLKEFQMQQTLVG
LPSLSLEK---NGGPSIIPIFKKGK----DHRRKLKPKIQPRDSLTLLPPVTNFM----G
LFKATKKTKDSHNI-FSFSSTITSDITN---------------VSRPRIVCLNQLGKHVQ
KANPEPAEG-------------------

------------------------------------------------------------
-----------MSQINNVAFT-AILLTPVDPXXXXXXXXXXXXXXXXXXXXXXXXXXXSI
SLEANYDQSSSCQLPPAYYDTRIGQILINIDYMLKALWHGIYMPKEKRARFSELWRTIVD
IDPDGKPQTNRDIFAEFSSAGLIDITKDPDFDGIYDEDMNADPTYNPNSPEEKAVFMKYA
ENILLKLTFSTTQVQQCENVFIFETAYWLTNAVRYNQDYLDICTYQRLQQRLYLQKKIXX
XXXXXEKEIRKGIGYLKFICFLIFLL--LKKKMKVPL-SSLLQPFS-DDKVKTERELPPF
IYGRDFKCQNFHYKEDQYFHVHGGIEFDISTPSIENALEDFKNNLEKIRDCAANTF----
AEDSGYKEYYSIPIMKLHGKSYYVISFELETFYQQLYKTQWWGAINEIVNNLRLKRLPLT
DAQLHEQFKKKFGFKKAMKCKSIPFGMKSAAERGLSAVFHTFSRRTSSSTINVSDE

PF00023 // ENSGT00680000100065_0_Domain_0 (537, 569)

AGYA
IFHQAALHNRVPIICQLCNANFNVNQRR

ENSGT00680000100065_0_Linker_0_1 (569, 588)

FIILS--------------

PF00023 // ENSGT00680000100065_0_Domain_1 (588, 620)

QGPTPLHLAAQAC
SLETTTCLLYFKADYALSE

ENSGT00680000100065_0_Linker_1_2 (620, 621)

K

PF00023 // ENSGT00680000100065_0_Domain_2 (621, 663)

RGWMPIHFAAFYDNICIIIVLCRKDPSLLE----------
AE

ENSGT00680000100065_0_Linker_2_3 (663, 667)

ATAE

PF00023 // ENSGT00680000100065_0_Domain_3 (667, 699)

NQCTPLLLAATSGALDTIQYLLSVGANWRKTD

ENSGT00680000100065_0_Linker_3_4 (699, 700)

I

PF00023 // ENSGT00680000100065_0_Domain_4 (700, 728)

KGNNIIHLAVLTFHTEVLKHV
IELNIPE

ENSGT00680000100065_0_Linker_4_5 (728, 761)

LPVWKTLVEMLQCESY-KRRMMAVMSLEVICLA

PF00514 // ENSGT00680000100065_0_Domain_5 (761, 801)

NDEYWKCILDAGTIPALINI
LKGSKIKLQCKTVGLLSNIS

ENSGT00680000100065_0_Linker_5_6 (801, 802)

T

PF00514 // ENSGT00680000100065_0_Domain_6 (802, 842)

HAKIVHALVEAGAIPALIDLLVSDEPELHSRCAVILYDI
AQLE-NKDVIAKYNGIPALINLLNLDIESVLVNVMNCLRVLCMG

PF00514 // ENSGT00680000100065_0_Domain_8 (885, 925)

NKNNQRAVRDHKGIPY
LITFLSSESDVLTAVSSVTIAEVARDNKEVQDAMAMEGAIPPLVALFVGKQLGVQVKGAM
AVEALASYNPAIQRAFLEKSLSKYLLKLLKAFQIDVKEQGAVTLWALAGQTLKQRKYMAE
QIGYNFIINMLLSPSAKMQYV---GGEAVIALSKDSRIHQNQICEGNGIAPLVRLLKIS-
IAEGTLLSVIKAVGSICIGVAHTS----NPISQQFLVEEKAFPVLIQLLRNHPSPNIKVE
V----AFSLACIVLRNDQLQNELQENEGFNYADVLYLLHSQDKDICLRAGYALTLFAFNS
RFQQYLILESGIITISTFEPFLESTFETEKAMAAFQIIILAKVIIDVDHITLTAR--GVT
ILVDSLYSVHSTTIALTGNLIATL----AHSRGGIPEAFTTLGTIQRLCYHLYSRQEEVR
MACSSALGYLTYNANAFRILLKECRNKPNQFLRITKNISRDASINPAFLKEFQMQQ-RVG
LPSLSLEK---NGGPSIIPVFKKGK----EHRRKLKPKIQPRDSLTFIPPVTNFM----G
LFKT-KKTTVSHSS-FSFSSAISSDITT---------------VSRPRIVLLSQLGKHVQ
KANPEPAEG-------------------

------------------------------------------------------------
-------------QINNASFTTAILLTPVDSTSLLDYREVHQIIRELSVGIYCLNQIPSI
SLEANYDQSSSCQLPPAYYDTRIGQILIRIDYMLKALWHGLYMPKEKRARFSELWRTILD
IDPDGKPQTNRNIFGEFHSSGLIDITKDPDFDGIYDNDMNEDPTYFPNSPEEKAVFMKYA
ENILLKMTFSTTQIQQHENIFIFETAYWLTNSIKYNQEYLDICTYQKIQQRLNLQKKIIE
NNLEKKVEIRRGLGYLKLICFLIPLLLSLKRKMKVPYLNSLLQSXX-XXXXXXXXXXXXX
XXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXXXXXXXXXFKKNVGKIRDCAASSF----
AEDSGYKEYYSIPVLEFQGKSYYVICFELETFYQKMYKTEWWGAINEIMNSLRLKRFPLS
DAQVHEQFKKKFGVKKTIKCKNIPFGMKSAVERGLSAVFHTLSRKTSSSTINISDE

PF00023 // ENSGT00680000100065_0_Domain_0 (537, 569)

TGYT
LFHHAALHNRVTIVSQLCNSNFNVNQRC

ENSGT00680000100065_0_Linker_0_1 (569, 588)

FNMST--------------

PF00023 // ENSGT00680000100065_0_Domain_1 (588, 620)

QGLTPLHLAAQAG
SLETALCLLSFRADYTLSE

ENSGT00680000100065_0_Linker_1_2 (620, 621)

K

PF00023 // ENSGT00680000100065_0_Domain_2 (621, 668)

RGWLPIHFAAFYDKICIIIVLYRKDPTLLE----------
AEATAENQ-RPLLLAATSGALDT-------------------------------------
---------------KMLQCESY-KRRMMAVMSLEVICLA

PF00514 // ENSGT00680000100065_0_Domain_5 (761, 801)

TETYWKFILDAGTISALINI
LKIPRIKLQCKTVGLLSNIS

ENSGT00680000100065_0_Linker_5_6 (801, 802)

T

PF00514 // ENSGT00680000100065_0_Domain_6 (802, 842)

HESVVQAIVDAGGIPVLINLLDSDEPELQSRCAVILYDI
AKFG-NKDVIAQYDGIPSLINLLKLNIENVLINVMNCIQVLCMG

PF00514 // ENSGT00680000100065_0_Domain_8 (885, 925)

NKNNQRAVRDHKGIPY
LISFLSSNSDALRAVASATIAEVARDNKEIQNSLAADGVIPPLIAIFKGTHLSVQVKGAQ
AVESLASFNSRLQRAFLENSLTKYLLKLLKVFQIDVKEQGAVALWALAGQTLKQQKFMAE
QIGYNFIINMLLSPSAKMQYV---GGEAVIALSKDSRLHQNQICEGNGIAPLVRLLRISK
IAEGTLLSVIKAVGSICIGVAHTS----

PF00514 // ENSGT00680000100065_0_Domain_10 (1109, 1154)

NPISQQYVVEENALPVLIQLLRNHPSPYIKVE
V----AFSLACIVLKNDKLQKELQKTEGFEYTDVLYLLHSPEKDVCLRAAYALTLFAYNN
RFQQFLILESGMITISIFEPFLGSIEETEKAMAAFQXXXXXXXXXXXXXXXXXXX--XXX
XXXXXXXXXXXXXXXXXXNLIASL----AHSRSGIPEAFATLGTIQRLCYHLYSGIDEXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXXXXX-XXX
XXXXXXXXXXXXXXXXXXXXXXXXKE----HRRKSKPKLQPTDSLTLIPPTTNFM----G
LLQASEKTTVS-QNLFSFSTTVSTDLVK---------------VSRPRIVFLNQLGKNAQ
KTSLEPAENQ------------------

------------------------------------------------------------
-----------MSQMNNVAFSTAILLTPVDTTALLDYREVHQIIRELAIGIYCLNQIPSI
SLEANYDQSSSCQLPPAYCDTRIGQILISVDYMLKALWHGIYMPKEKRARFSELWRTIMD
IDPDGKPQTKRDIFAEFSSAGLIDITKDPDFNGIYDEDMNEDPTYNPNSPEEIATFMKYA
ENIMLKLTFSTTQVQQYENVFIFETAYWLTNAIKYNQDYLDICTYQRLQQRLYLQKKIIQ
KHFEKKKEIRKGIEYLKLICFLTPFLLSLKKKMKVPYLSSLLQPFS-DDNVKTERELPPF
IYGRDFKCQNFHYKADQYFHVHGGIEFDISTPSIENALEDFKNNLEKIRDCAANTF----
AEESGYREYYSIPVMKFNGKSYYVISFELETFYQQLYKTQWWGAINEIVNTLRLKRLPLT
DAQLHEQFKKKFGFKKAMKCKSIPFGMKSAVERGLSAVFHTFSRKTSSSTINISDE

PF00023 // ENSGT00680000100065_0_Domain_0 (537, 569)

AGYA
IFHHAALHNRVPIVCQLCNANFNVNQRR

ENSGT00680000100065_0_Linker_0_1 (569, 588)

FTMVS--------------

PF00023 // ENSGT00680000100065_0_Domain_1 (588, 620)

QGPTPLHLAAQAC
SLETTICLLCFKADYMLSE

ENSGT00680000100065_0_Linker_1_2 (620, 621)

K

PF00023 // ENSGT00680000100065_0_Domain_2 (621, 661)

RGWMPIHFAAFYDNICIIIVLCRKDPTLLE----------

ENSGT00680000100065_0_Linker_2_3 (661, 667)

AEATAE

PF00023 // ENSGT00680000100065_0_Domain_3 (667, 699)

NQCTPLLLAATSGALDTIQYLLSLGANWRKTD

ENSGT00680000100065_0_Linker_3_4 (699, 700)

I

PF00023 // ENSGT00680000100065_0_Domain_4 (700, 722)

KGNNIIHLSVLTFHTEVLKHI
IELNIPELPVWKTLVEMLQCESY-KRRMMAIMSLEVICLANDGYWESILDAGTIPALVIK
SSKXXXXXXXXXXXXXXXXXXXXXXXXX--XXXX-XXXXXXXXXXXXXXXXXXXXXXXXX
XXXX-XXXXXXXXNGIPALINLLNLDIESVLVNVMNCIRVLCTGNENNQRAVRDHKGITY
LITFLSSDSDVLKAVSSVTIAEVARG

PF00514 // ENSGT00680000100065_0_Domain_9 (927, 967)

NKEVQDAMAMEGAIPPLVALFKGKHLSVQVKGAM
AVEALA

ENSGT00680000100065_0_Linker_9_10 (967, 1109)

SYNPAIQRAFLEKSLSKYLLKLLKAFQTDVKEQGAAALWALAGQTLKQQKYMAE
QIGYNFIINMLLSPSAKMQYV---GGEAVIALSKDSRMHQNQICEGNGIAPLVRLLRISK
IAEGTLLSVIKAVGSICIGVAHTS----

PF00514 // ENSGT00680000100065_0_Domain_10 (1109, 1154)

NPISQQFVVDENALPVLIQLLRNHPSPNIKVE
V----AFSLACIVLRNDLLQYELQEKEGFNYDDVLYLLHSQDKXXXXXXXXSLTLFAFNN
RFQQYLILESGIMTISIFEPFLESTIETEKAMAAFQIIILAKVIIDVDYITLSAR--GVT
ILVDSLYSVHSTTIVLTGSLIARL----AHSRAGIPESVTCLGNIPRLCIQLNAETDEVR
MACSSALGYLTYNANAFRILLKECRNKPNQFLRITNNISRDASINPVFLKEFQMQQ-RVG
LPSSSLEK---NGGPSIIPVFKKAKV----S-----------------------------
---------------------------------------------RPRIVFLSQLGKRVQ
KANPELAEG-------------------

MLRLPKKGAPRFDQNQDEETYLENLAVQRNASAFFEKYDRSEVQELLTTALVSWLSAKED
VRSQLDMPCGIMSQMNNVGFSTAILLTPVDPTALLDYREVHQIIRELAVGIYCLNQIPSI
SLEANYDQSSSCQLPPAYFDTRIGQILINIDYMLKALWHGIYMPKEKRARFSELWRTIMD
IDPDGKPQTNRDIFAEFSSAGLIDITKDPDFDGIYDEDMNDDPTYNPNSPEEKAVFMKYA
EYILLKMTFSTTQVQQCENVFIFETAYWLTNAIKCNQDNLDICTYQRLQQRLYLQKKIIQ
KHFEKKKEIRKGIGYLKLICFLTPFLLSLKKKMKVPYLSGLLPPFS-DDKVKTERELPPF
IYGRDFKCQNFHYKEDQYFHVHGGIEFDISTPSIENALEDFKNNLEKIRDCAVNAL----
AEDSGYKEHYSIPVMKFNGKSYYVISFELEIFYQQLYKTQWWGAINEIVNNLRLKRLPLT
DAQLHEQFKKKFGFKKAMKCKSIPFGMKSAVERGLYAVFHTFSRKTSSSTINISDEAGYA
IFHHAALHNRVPIICQLCNANFNVNQRRFIILNQE-ELKRIDRRIGRNSPTPLHLAAQTC
SLETTICLLCFKADYTLSEKRGWMPIHFAAFYDNICIIIVLCRKDPSLLE----------
AEATADNQCTPLLLAATSGALDSIQYLLSLGANWRKTDIKGNNIIHLSVLTFHTEVLKHI
IELNIPELPVWKTLVEMLQCESY-KRRMMAVMSLEVICLA

PF00514 // ENSGT00680000100065_0_Domain_5 (761, 800)

NDEYWKCILDAGTIPALINL
LKGSKIKLQCKTVGLLSNISTHPSIVHALVEAGAIPALINLLVSEEPELHSRCAVILYDI
AQLE-NKDVVAKHNGIPALINLLNLDIESVLVNVMNCMRVLCMGNKNNQRAVKDHKGIPY
LISFLSSDSDILTAVSSVTIAEVARDNKEVQDAMALEGAIPPLVALFKGKQLSVQVKGAM
AVEALASHNPAIQRAFLEKSLSKYLLKLLKAFQIDVKEQGAVALWALAGQTLKQQKYMAE
QIGYNFIINMLLSPSAKMQYV---GGEAVIALSKDSKIHQNQICEGNGIAPLVRLLRISK
IADGTLLSVIKAVGSICIGVAHTS----NPVSQQFVVDENAFPVLIQLLRNHPSPNIKVE
V----AFSLACIVLRNDLLQKELQEIEGFDYADVLYLLHSEDKNICLRAGYALTLFAFNN
RFQQYLILENGKMSISIFEPFLESTIETEKAMAAFQIIVLAKVIIDVDHITLTAR--GVT
ILVDSLNSADSSTIVLTGNLIATL----AHSRAGIPEAFTTLGTVQQLCYHLYSGQEEVR
MACSSALGYLTYNANAFRLLLKECRNKPNQFLRITSYISRDASINPAFLKEFEMQQ-KVG
LPSLSLEK---NGGPSIIPVFKKGRK---EHRRKLKPKVQPRDSLTFIPPVTNFM----G
LFKTTKKTTVSHNI-FSFSSAISSDIIT---------------VSRPRIVLLNQLGKHVQ
KANPEP----------------------

MLRLPKKGLPRIDQAQDEETYLENLAVQRNASAFFENYDRSEIQELLTTALASWLSTKED
GRSQLEFPSGIMSQMNNVGFSTVILLMPADPTALLDYREVHQIIRELAVGIYCLNQIPSI
SLEANYDQSSSCQLPPAYFDTRIGQILIHIDYMLKALWHGIYMPKEKRTRFSEMWRTIFD
IDPDGKPQTTKDIFAEFNSSGLIDITEDPDFSGIYDQDLNEDPTYDPNSPEEKAVFMKYA
ENILLKLTFSTTQVQQCENVFIFEAAYWLTNAIKYTQDYLDICTYQRLQQRLYLQKKIIQ
KHFEKKKEIRRGISYLKLICFLVPFLLSLKKKMKVPYLNSLLPPFS-DDKVKTERELPPF
IYGRDFKCQNFHYKENQYFHVHGGIEFDITTPSIENALDDFKNNLERIRECAANTF----
KEDYGYKEYYSIPVMEFCGKSYYVIYFDLEIFYQQLYKTQWWGAINEIMNTLRVKRLPLT
DAQLHEQFKKKFGFKKAMKCKSIPFGLKSAVERGLSAIFHTFSRKTSSSIINVSDESGYA
IFHHAALHNRISIICHLCDANFNVNQRRFVMFSQ--ESSKMDVKKERNGPTPLHLAAQAC
SLETTLCLLSFKADYTLSEKRGWMPIHFAAFYDNICIIMVLHRKDPSLIE----------
AEATAENQCTPLLLAATSGALDTIQYLLSLGANWRKTDTKGNNIIHLSVLTFHTEVLKHI
IELNNPELPVWKTLVEMLKCENF-KRRMMAIMSLEVICLANEH

PF00514 // ENSGT00680000100065_0_Domain_5 (764, 800)

YWKCILDAGTIPALINL
LKSPKIKLQCKTIGLLSNISTHESVVNALVEAGAIPVLINLLVSEEPELHSRCAVILYDI
AQYG-NKNVISKYNGIPALINLLTINIENVLVNVMNCMRVLCIGNETNQRAVRDHNGIQH
LIRFLSSDSDVLQAVSSATIAEVARGNKDVQDAMAQEGAIRPLVALFIGKQLSVQVKGAM
AVEALASYNPPIQKAFLEHQLTGYLLKLLKAFQIDIKEQGAVALWALAGQTLKQQKYMAE
QIGYNFIINMLLSPSAKMQYV---GGEAVIALSKDSRMHQNQICEGNGIAPLVRLLRINK
IAEGTLLSVVRAVGSICIGVAHTS----NPISQHFIVDENAFPVLMQLLREHPSPNIKVE
V----AFSLACIVLGNDELQKELQENEGFKYSDVLYLLHSTDKDICLRAAYALTLFAFNN
RFQQFLILESGKITISIFEPFLESTVETEKAMAAFQIIVLAKVIIDVDHITLSAR--GVT
ILVNSLYSYQHTTIVLTGNLIASL----AHSRAGIPEAFITLGTIQRLCYHLYSGREEVR
TACSCALGYLTYNANGFRILLKECRNKPNQFLRIRNNISRDASINPAFLKEFQRQQ-MIG
LPSLRYLV--------IVIYKKLWKE----HQRKAKPKIQPRDSLTLMPPVTNFV----G
LFKTSKKSKVS-HNIFSFSSAISSDIIN---------------VSRPRIVYLNQLGKKEQ
KDNLEPGEGQ------------------

MLRLPKKGLNRLDQVQDEETYLENLAVQRNASAFFEKYDRSEVQELLTTALVSWLSTKED
VRSQIDIPCGIMSQINNVGFSTAILLTPMDPTALLDYREVHQIIRELSIGIYCLNQIPSI
SLEANYDQSSSCQLPPAYFDTRIGQILINIDYMLKALWHGIYMPKEKRARFSELWRTILD
IDPDGKPQTNKSIFAEFSSAGLIDITKDPDFEGIYDEDMNEDPTYNPNSPEEKAVFMKYA
ENILLKLTFSTTQVQQYENVFIFETAYWLTNAIKYNQDYLDICTYQRLQQRLYLQKKVIQ
KHLEKKQDIRRGMGYLKLICFLTPFLLSLKKKMKVPYLNSLLQPFS-DDKVKTERELPPF
IFGRDFKCQNFHYNENQYFHVHGGIEFDISTPPIENALEDFQNNLEKIRDCAANTF----
VEDSGYKGYYSIPVMEFHGKSYYVICFELETFYQQLYKTQWWA-INEIVNNLRPKRLPLT
DAQLHEQFRKNLV-SKSYECRSIPFGMKSAVERGLAAVFHTFSRKTSSSTINVSDE

PF00023 // ENSGT00680000100065_0_Domain_0 (537, 569)

GGYA
IFHHAALHNRVAIICQLCNANFNVNQRR

ENSGT00680000100065_0_Linker_0_1 (569, 588)

FIMFT--------------

PF00023 // ENSGT00680000100065_0_Domain_1 (588, 620)

QGPTPLHLAAQAC
SLEATICLLCFKADYTLSE

ENSGT00680000100065_0_Linker_1_2 (620, 621)

K

PF00023 // ENSGT00680000100065_0_Domain_2 (621, 663)

RGWMPIHFAAFYDNICIIIALCRKDPSLLE----------
AE

ENSGT00680000100065_0_Linker_2_3 (663, 667)

ATAE

PF00023 // ENSGT00680000100065_0_Domain_3 (667, 699)

NQCTPLLLAATSGALDTIQYLFSLGANWRKTD

ENSGT00680000100065_0_Linker_3_4 (699, 700)

I

PF00023 // ENSGT00680000100065_0_Domain_4 (700, 722)

KGNNIIHLSVLTFHTEVLKHI
I

ENSGT00680000100065_0_Linker_4_5 (722, 761)

ELNIPELPVWKTLVEMLQCESY-KRRMMAVMSLEVICLA

PF00514 // ENSGT00680000100065_0_Domain_5 (761, 801)

NDQYWKCILDAGTIPALINL
LKCPKIKLQCKAVGLLSNIS

ENSGT00680000100065_0_Linker_5_6 (801, 802)

T

PF00514 // ENSGT00680000100065_0_Domain_6 (802, 842)

HVPVVHALVEAEGIPALINLLVSEEPELHSRCAVILYDI
AQLG-NKDVIAKYNGIPALINLLQLNIECVLVNVMNCIRVLCIR

PF00514 // ENSGT00680000100065_0_Domain_8 (885, 925)

NEDNQRAVRDHKGIKY
LITFLSSDSDVLKAVSSATIAEVARDNTGVQDALAMEGVIPPLVALFKGKQLSVQVKGAM
AVESLASHNPAIQKAFLEKSLTKYLLKLLKAFKIDVKEQGAVALWALAGQTLKQQKYMAE
QIGYNFIINMLLSPSAKMQYV---GGEAVIALSKDSRMHQNQICEGNGIAPLVRLLRITK
IAEGTLLSVIRAVGSICIGVAHTS----NPISQHYVVEENAFPVLIQLLRNHPSANIKVE
V----AFSLACIVLRNDLLQNELQETEGFKYDDVLYLLHSPDKDICLRAGYALTLFAFNN
RFQQYLILESGTMTISIFEPFLESTIETEKAMAAFQIIVLAKVIIDVDHIALSAR--GVN
ILVDSLYSDQASTTVLTGNLIASL----AHSRAGIPEAFTTLGTIQRLCYHLYSEKEEVR
SACSCALGYLTYNANAFRILLKECRNKPNQFIRIRNNISRDASINPAFLKEFEMQQ-KVG
LPSLSLEK---NGGPSIIPVFKKGK----EHQRKSKPKIQPKDSLTLIPPVTNFM----G
LFRTTEKTIASHNI-FYFSSSSSSDIIK---------------VSRPRIVVLSQLGKHVQ
KGNSEPPEG-------------------

MLRLPKKGLPRLEQVQDEDTYLENLAIQRNASAFFEKYDRSEIQELLTTALVSWLSAKED
VRSQVELPCGIMSQMNNVGFSTAILLTPVDPTALLDYREVHQMIRELAIGIYCLNQIPSI
SLEANYDQSSSCQLPPAYYDTRIGQILINIDYMLKALWHGIYMPKEKRARFSELWRAIMD
IDPDGKPQTNKDIFSEFSSAGLTDITKDPDFNEIYDEDVNEDPTYDPNSPEETAVFMKYA
ENIMLKLTFSTTQIQQYENVFIFETGYWLTNAIKYNQDYLDICTYQRLQQRLYLQKKIIQ
KHFEKKKDIRRGIGYLKLICFLIPFLLSLKKKMKVPYLSSLLQPFS-DDKVKTERELPPF
IYGRDFKCQNFHYKENQYFHVHGGIEFDISTPSIENALEDFQKNLEKIRDCAANTF----
IEDSGYKEYYSIPVMEFHGKSYYVIYFELETFYQQLYKTQWWGAINEIVNNLRLKRLPLT
DAQLHEQFKKKLGFKRAMKCKSIPFGMKSAVERGLSAVFHTFSRKTSSSTISVSDEAGYT
I

PF12796 // ENSGT00680000100065_0_Domain_1 (542, 642)

FHHAALHNRVSIICQLCNANFKVNQRRFVTFS--------------QGPTPLHLAAQAC
SLETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLE----------
AEATAENQCTPLLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYI
IKLNIPELPVWKTLVEMLQCESY-KRRMMAVMSLEVICLAN

PF00514 // ENSGT00680000100065_0_Domain_5 (762, 800)

DQYWRCILDAGTIPALINL
LKSSKIKLQCKTVGLLSNISTHKSAVHALVEAGGIPSLINLLVCDEPEVHSRCAVILYDI
AQCE-NKDVIAKYNGIPSLINLLNLNIENVLVNVMNCIRVLCIGNENNQRAVREHKGLPY
LIRFLSSDSDVLKAVSSAAIAEVGRDNKEIQDAIAMEGAIPPLVALFKGKQISVQMKGAM
AVESLASHNALIQKAFLEKSLTKYLLKLLKAFQIDVKEQGAVALWALAGQTLKQQKYMAE
QIGYSFIINMLLSPSAKMQYV---GGEAVIALSKDSRMHQNQICEGNGIAPLVRLLRVST
IAEGTLLSVIRAVGSICIGVAHTS----NPVSQQFVVDENAFPVLIQLLRNHPSPNIKVE
V----AFSLACIVLGNDVLQKDLHENEGFEYADVLYLLHSTEKDICLRAGYALTLFAFNN
RFQQYLILESGIMTISIFERFLESTVETEKAMAAFQIVVLAKVIRDMDHITLSAR--GVT
ILVDSLYSVQTSTIVLTGNLIASL----AHSRAGIPEAFTTLGTIQRLCYHLYSGIEEVR
AACSSALGYLTYNANAFRILLKECRNKPNQFIRIKNNISRDASINPAFLKEFQMQQTLVG
LPSLSLEK---NGGPSIIPIFKRGK----EHRRKLKPKIQPKDSLTLLPPVTNFM----G
LFKATKKTKDSHNI-FSFSSTITSDITN---------------VSRPRIVCLNQLGKHVQ
KANPEPAEG-------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------SIPFGMKSAVERGLSAVFHTFSRRTSSSTINVSDEAGYA
I

PF12796 // ENSGT00680000100065_0_Domain_1 (542, 642)

FHHAALHNRVSIICQLCNANFNVNQRRFIIFTPA-DSSKGDTKKERNGPTPLHLACQAC
SLESTVCLLCFKADYTLSEKRGWMPIHFAAFYDNICIIIVLCRKDPSLLE----------
AEATAENQCTPLLLAATSGALDTIQYLFSLGANWRKTDIKGNNIIHLSVLTFHTEVLKYI
IELNIPELPVWKTLVEMLQCESF-KRRMMAVMSLEVICLAN

PF00514 // ENSGT00680000100065_0_Domain_5 (762, 800)

DQYWKCILDAGAIPALINL
LKYPKIKLQCKTVGLLSNISTHVSVVHALVEGGGIPALINLLGSDEPELHSRCAVILYDI
AMNE-NKDVIAQYNGIPALINLLNLDMESVLVNVMNCIRVLCMGNEGNQRAMVDHNGIQY
LIRFLSSDSDILKAVSSATIAEVGRDNRDVQDAIAMEGAIPPLVDLFKGKQLSVQVKGAM
AVESLANYNPLIQKAFLKRNLTKDLLKLLKAFQLNVKEQGAVALWALAGQTLKQQKYMAE
QIGYNFIINMLLSPSAKMQYV---GGEAVIALSKDSKIHQNQICEGNGIAPLVRLLRINK
IAEGTLLSVIRAVGSICVGVAHTS----NPLSQQYVVEENALPVLIQLLRTHPSLNIKVE
V----AFSLACIVLGNDSLQKELQEKEGFVYSDVLYLLHSKDKEICLRAGYALTLFAFNN
RFQQYLILENGRITLSIFEPFLRSKVETERAMAAFQIIVLAKVIIDVDHIAASAR--GVT
ILVDSLYSAHFPTIVLTGNLIASL----AHCRVGIPDAFTTLGAIRRLCYHLYSGREEVR
TACSCALGYLTYNAYAFRILLSECRNKPNQFLRITNNISRDAKINPAFLKEFQMQQ-HVG
LPSLSLEK---NGGPSVIPVFKKGK----EHRRKARPKIQPKDSLTLIPPVTNLK----G
LFRTAKKTNVSHNT-FSFSSGISSDIIT---------------VSRPRIVYLNMLGKHEQ
KSSPELSES-------------------

MLRLPKKGLPRFEQVQDEETYLENLAIQRNASAFFEKYDRSEIQELLTTALVSWLSTKED
VRSQGDLPCGIMSQMNNVGFSTAILLTPVDPTALLDYREVHQMIRELAIGIYCLNQIPSI
SLEANYDQSSSCQLPPAYYDTRIGQILINIDYMLKALWHGIYMPKEKRARFSELWRTIMD
IDADGKPQTNKDIFSEFSSAGLTDITKDPDFNEIYDEDVNEDPTYDPNSPEETAVFMKYA
ENIMLKLTFSTTQVQQYENVFIFETDYWLTNAIKYNQDYLDICTYQRLQQRLYLQKKIIQ
KHFEKKKDIRRGIGYLKLICFLIPFLLSLKKKMKVPYLGSLLQPFS-DDKVKTERELPPF
IYGRDFKCQNFHYKENQYFHVHGGIEFDISTPSIENALEDFQKNLEKIRDCAANAF----
IEDSGYKEYYSIPVMEFHGKSYYVMYFELETFYQQLYKTQWWGAINEIMNNLRPKRLPLT
DAQLHEQFKKKFGFKRAMKCKSIPFGMKSAVERGLSAVFHTFSRKTSSSTINVSDEAGYT
I

PF12796 // ENSGT00680000100065_0_Domain_1 (542, 644)

FHHAALHNRVSIICQLCNANFKVNQRRFVTFG--------------QGPTPLHLAAQAC
SLETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIVIALCRKDPSLLE----------
AEATAENQCTPLLLAATSGALDTIQYLFSIGANWRKTDTKGNNIIHLSVLTFHTEVLKYI
IKLNIPELPVWKTLVEMLQSESY-KRRMMAVMSLEVICLAN

PF00514 // ENSGT00680000100065_0_Domain_5 (762, 800)

DQYWRCILDAGTIPALINL
LKSSKIKLQCKTVGLLSNISTHKRAVRALVEAGGIPSLINLLVCDEPEVHSRCAVILYDI
AQCE-NKDVIAKYNGIPSLINLLNLNIENVLVNVMNCIRVLCIGNENNQRAVREHKGLPY
LIRFLSSDSDVLKAVSSAAIAEVGRDNKEIQDAIAMEGAIPPLVALFKGKQISVQMKGAM
AVESLASHNPLIQKAFLEKSLTKYLLKLLKAFQIDVKEQGAIALWALAGQTLKQQKYMAE
QIGYSFIINMLLSPSAKMQYV---GGEAVIALSKDSRMHQNQICEGNGIAPLVRLLRIST
IAEGTLLSVIRAVGSVCIGVAHTS----NPVSQQFVVDENAFPVLIQLLRNHPSPNIKVE
V----AFSLACIVLGNDVLQKDLHENEGFEYADVLYLLHSTEKDICLRAGYALTLFAFNN
RFQQYLILESGIMTISIFEPFLESIVETEKAMAAFQIVVLAKVIRDVDHITLSAR--GVT
ILVDCLYSVQTSTIVLTGNLIASL----AHSRAGIPEAFTTLGTIQRLCYHLYSGTEEVR
AACSSALGYLTYNANAFRILFKECRNKPNQFIRIKNNISRDASINPAFLKEFQMQQTLVG
LPSLSLEK---NGGPSIIPIFKKAC----HLVLCPK-TFQEAENLKLLELMPTDS----D
LQKSKEL---KKEI-LLYWST---------------------------------------
----------------------------

MLRISKKGIVRFDQIQDEETYLENLAVQRNASAFFEKYERSEIQELLTTAIVSWLAAKDD
VRSQLDIPCGLMSQINNVGFSTAILLTPVDPTAHLDYREVHQILRELAVGIYCLNQIPSI
SLEANYDQSSSCQLPPAYYDTRIGQILIHIDYMLKALWHGIYMPKEKRARFSELWRTIMD
IDQDGKPQTTKDIFSEFSSAGLVDITNDPDFYGIYDEDMNEDPTYEPNSPEEKAIFMKYA
ENIMLKLTFSTTQVQQHENIFIFETDYWLTNAIKYNQDHLDICTYQRLQQRLYLQKKVIQ
KHFENKKEIRKGMGYLKLICFLIPFLLSLKKKMKVPYLNSLLPPFS-EDKVKTERELPPF
IYGRDFKCQNFDYKENQYFHVHGGIEFDISTSPVENAMDDFKNNVEQIRECAANTF----
VEDSGYKEFYSVPVMEFYGKSYYVIYFDLEIFYQQLYKTQWWGAINEIVNSLRLKRLPLT
EAQLHEQFKKKFGFKKAMKCKSIPFGMKSAVERGLSAVFHTFSRKTSSSTLNVSDEAGYA
IFHHAALHNRVSIICQLCNANFNVNQRRFIMFSQA-ESSKMDMKKERNGPTPLHLAAQAC
SLETTICLLCFKADYMLTEKRGWMPIHFAAFYDNICILIALCRKDPSLLE----------
AEATAENQCTPLLLAATSGALDTIQYLFSLGANWRKTDTKGNNIIHLSVLTFHTEVLKYI
IELDIPELPVWKTLVEMLQCESL-KRRMMAVMSLEVICLAKDRYW

PF00514 // ENSGT00680000100065_0_Domain_5 (766, 800)

KCILDAGTIPALINL
LKCPRIKLQCKTVGLLSNI

ENSGT00680000100065_0_Linker_5_6 (800, 808)

STHVSVVH

PF00514 // ENSGT00680000100065_0_Domain_6 (808, 838)

ALVEAGGIPALINLLSSDEPELHSRCAVILYDI
ARCE-NKDVIAKWNGIPALVNLLNLNIESVLVNVMNCIRVLCMGNESNQRAMIEHKGIQY
LIRFLSSDSDTLKAVSSATIAEVGRDNKEVQDALAMEGAIPPLVALFKGKQLSVQVKGAM
AVESLANCNPLIQRAFLERKLTKDLLKLLKAFQLDVKEQGARALWALAGQTLKQQKFMAE
QIGYNFIINMLLSPSAKMQYV---GGEAVMALSKDSRLHQNQICEGNGIAPLVRLLRINK
IAEGTLLSVIRAVGSICIGVAHTS----NPLSQQFVVEENAFPVLIQLLRSHPSLNIKVE
V----AFSLACIVLGNDLLQKELQEKEGFQYSDVLYLLHSRDKDICLRAGYALTLFAYNN
RFQQYLILEKGMITLSIFEPFLQSKVETERAMAAFQIIVLAKVIIDVDHITLLAR--GVN
ILVDSLYSTHVPTIVLAGNLIATL----AHSRPGIPDAFMTVGAIQRLCYHLYSGREEVR
TACSCALGYLTYNAYAFRILLAECRNKPNQFLRIMNNISRDAKINPAFLKEFQMQQ-SVG
LPSLSLEK---NGGPSVIPVFKKGK----EHRRKARPKIQPKDSLTLIPPVTNFM----G
LFRTPKNTNVYHNI-FSFSSGVSSDIIN---------------VSRPRIVCLNKLKHQEQ
KANPEPTES-------------------

------------------------------------------------------------
-----------MSQMNNVGFSTAILLTPVDPTALLDYREVHQIIRELAVGIYCLNQIPSI
SLEANYDQSSSCHLPPAYYDTRVGQILIKIDYMLKALWHGMYMPKEKRARFSELWRTIMD
IDPDGKPQTNRDIL-EFSSAGLIDITKDPDFNGIYDEDMNEDPTYDPNSPEEKAVFMKYA
ENIMLKLTFSTTQIQQHENIFIFETAYWLTNAIKCNQDYLDICTYQRLQQRLYLQKKVIQ
KHFEKKKEIRRGIGYLKLICFLIPFLLSLKKKMKVPYLSSLLQPFS-DDKVKTERELPPF
IYGRNFKCQNFHYKENQYFHVHGGIEFDISTPPIENALEDIKKNLEKIRVCAANIF----
AEDSGYKEHYSIPVTELHGKRYYVICFELETFYQQLYKTQWWGAINEIVKNLRVKRLPLT
DAQLHEQFKKKFGFKKAMKCKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--X--XXX-XX--XXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX------XXXXXXXXXX----------
XXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXPELPVWKTLVXXXXXXXX-XXXXXXXXXXXXX

PF00514 // ENSGT00680000100065_0_Domain_5 (758, 801)

XXANDR---YIILAGSIPALINI
LKTSKIKLQCKTVGLLSNIS

ENSGT00680000100065_0_Linker_5_6 (801, 802)

T

PF00514 // ENSGT00680000100065_0_Domain_6 (802, 842)

HRSVVHALVEAGGIPALINLLTYDEPELHSRCAVILYDI
AQCE-SKDVIAKYNGVPALINLLKLDIEGVLVNVMNCIRVLCIGNVNNQRAVRDHKGIHH
LIRFLNSDSDVLKALSSATIAAVARVNTEVQLPIVKDLSL--SAILFKGKHISVQIKGGA
GSESTASQDAHILAVFGEAVSTTDL--WILAFQLDVKEQGAVALWALAGQTLKQQKYMAE
QIGYNFIINMLLSPSAKMQYV---GGEAVIALSKDSKMHQNQICEGNGIAPLVRLLRMNK
IAEGTLLSVIRAVGSICIGVAHTS----NPVSQYCVAEENAFPILIQLLRNHPSPNIKVE
V----AFSLACIVLRNDVLQNELQENEGFMYSDVLYLLHSSDKDICLRAGYALTLFAFNN
RFQQFLILESGLMTISIFEPYLESTVETEKAMAAFQXXXXXXXXXXXXXXXXXXX--X--
----------------------------X---------------XXX-------------
-------------------------------------------------XXXXXXX-XXX
XXXXXIGELEKNGGPSIIPIFKKGKE----HRRKLKPKIQPRDSLTLIPPVANIM----G
LFNAAKKTTVS-HNIFSFSSAISPDIIN---------------VSRPRIVCLSQLGKHVQ
KTNPEPAEG-------------------

------------------------------------------------------------
-----------MSQINNVGFSTAILLTPIDSTALLDYREVHQILRELSVGIYCLNQIPSI
SLEANYDQSSSCQLPPAYFDTRIGQILINIDYMLKALWHGIYMPKEKRARFSEMWRTVLD
IDPDGKPQTNKDIFTEFSSAGLTDITKDPDFDSIYDEDMNEDPTYNPNSPEEKDVFMKYA
ENIMLKLTFSTTQVQQCENVFIVETAYWLTNAIKCNQDYLDICTYQRLQQRLYLQKKIIQ
KHFEKKKEIRKGIGYLKLICFLIPFLLSLKKKMKVPYLNTLLQPFS-DDKVKTERELPPF
IYGRDFKCQNFHYKENQYFHVHGGIEFDISTPPIEDAMEDF-------------------
----------KIPVMNFHGKSYYVIYFELETFYQQLYKTQWWGAINEIVNNLRPKRLPLT
DAQLHEQFKKKFGFKKAMKCKSIPFGMKSAVERGLSAIFHTFSRKTSSSTINVSDE

PF00023 // ENSGT00680000100065_0_Domain_0 (537, 569)

AGYA
IFHHAALHNRVSIICQLCNANFNVNQRR

ENSGT00680000100065_0_Linker_0_1 (569, 588)

FIMFS--------------

PF00023 // ENSGT00680000100065_0_Domain_1 (588, 620)

QGPTPLHLAAQAC
SLEATICLLCFKADYMLSEKRGWMPIHFGAFYVNVCIIIALCRKDLSLLE----------
AEATAE

PF00023 // ENSGT00680000100065_0_Domain_3 (667, 699)

NQCTPLLLAATSGALDTIQYLFSLGANWRKTDIKGNNIIHLSVLTFHTEVLKHI
IALNIPELPVWKTLVXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXTIPALINL
LKIPKIKLQCKVVGLLSNISI

PF00514 // ENSGT00680000100065_0_Domain_6 (802, 842)

HVSVVDTLVEAGGIPALINLLVSEEPELHSRCALILYDI
AQLG-NRDVIAKYXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXVLKAVSSATIAEVARD

PF00514 // ENSGT00680000100065_0_Domain_9 (927, 967)

NTEVQNAIAMEGVIPPLVALFKGKQLSVQVKGAM
AVESLASYNPAIQKGFLEKSLTKYLLKLLKAFQIDVKEQGAVALGXXXXXXXXXXXXXXX
XXXX-XXXXXXXXXXXXXXXXX--XGEAVIALSKDSRMHQNQICEGNGIAPLVRLLRISK
IAEGTLLSVIRAVGSICIXXXXXX----XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVE
V----VFSLACIVLRNDLLQKELQQTEGFQYADVLYLLHSPDKDICLRAGYALTLFAFNN
HFQQYLILESGTMTISIFEPFLESTVETEKAMAAFQIVILAKVIIDVDHITLSAR--GVN
ILIGSLYSVHSTTIILTGNLIASL----AHSRAGIPEAFTALGTIQRLCYHLYSEKEEVR
AACSCALGYLTYNANAFRILLKECRNKPNQFIRITNNISRDASINPAFLKEFQLQQ-RVG
LPSLSLEK---NGGPSIIPIFKKGKE-----HRKSKLKIQPRDSWAFIPPATKFM----G
LFRTTKKTTVFHHSPLSF---KNSDIIH---------------SAGTR------------
----------------------------

MLRISKKGIVRFDQVQDEETYLENLAVQRNASAFFEKYDRSEVQELLTTTVVSWLSSKDD
VRSQLDIPSGLMSQINNVGFSNAILLTPVDPTAHLDYREVHQILRELAVGIYCLNQIPSI
SLEANYDQSSSCQLPPLIEMAVSGPENFIAPFLVFCLLLPIF------------------
---------FSFLSSIFYCEGLIDITNDPDFVGIYDEDMNEDPTYDPNSPEEKAIFMKYA
ENIMLKLTFSTTRVQQHENIFIFETDYWITNAIKFNQDYLDICTYQRLQQRLYLQKKVIQ
KHFEKKKEVRRGMSYLKLICFLIPFLLSLKKKMKVPYLNSLLPPFS-DDKVKTERELPPF
IYGRDFKCQNFDYKEHQYFHVHGGIEFDISTSPVESALDEFQNNIGKIRECAANTF----
AEDSGYKEFYSVPVMEFYGKSYYVIYFELEIFYQQLHKTQWWGAINEIVNNLRVKRLPLT
EAQLHEQFKKKFGFKKAMKCKSIPFGMKSAVERGLSAVFHTFSRRTSSSTINVSDEAGYA
IFHHAALHNRVSIICQLCNANFNVNQRRFIIFTPA-DSSKGDTKKERNGPTPLHLACQAC
SLESTVCLLCFKADYTLSEKRGWMPIHFAAFYDNICIIIVLCRKDPSLLE----------
AEATAENQCTPLLLAATSGALDTIQYLFSLGANWRKTDIKGNNIIHLSVLTFHTEVLKYI
IELNIPELPVWKTLVEMLQCESF-KRRMMAVMSLEVICLAN

PF00514 // ENSGT00680000100065_0_Domain_5 (762, 800)

DQYWKCILDAGAIPALINL
LKYPKIKLQCKTVGLLSNISTHVSVVHALVEGGGIPALINLLGSDEPELHSRCAVILYDI
AMNE-NKDVIAQYNGIPALINLLNLDMESVLVNVMNCIRVLCMGNEGNQRAMVDHNGIQY
LIRFLSSDSDILKAVSSATIAEVGRDNRDVQDAIAMEGAIPPLVDLFKGKQLSVQVKGAM
AVESLANYNPLIQKAFLKRNLTKDLLKLLKAFQLNVKEQGAVALWALAGQTLKQQKYMAE
QIGYNFIINMLLSPSAKMQYV---GGEAVIALSKDSKIHQNQICEGNGIAPLVRLLRINK
IAEGTLLSVIRAVGSICVGVAHTS----NPLSQQYVVEENALPVLIQLLRTHPSLNIKVE
V----AFSLACIVLGNDSLQKELQEKEGFVYSDVLYLLHSKDKEICLRAGYALTLFAFNN
RFQQYLILENGRITLSIFEPFLRSKVETERAMAAFQIIVLAKVIIDVDHIAASAR--GVT
ILVDSLYSAHFPTIVLTGNLIASL----AHCRVGIPDAFTTLGAIRRLCYHLYSGREEVR
TACSCALGYLTYNAYAFRILLSECRNKPNQFLRITNNISRDAKINPAFLKEFQMQQ-HVG
LPSLSLEK---NGGPSVIPVFKK-------------------------------------
------------------------------------------------------------
----------------------------

MLRLPKKGLPRFEQVQDEETYLENLAIQRNASAFFEKYDRSEIQELLTTALVSWLSTKED
VRSQGDLPCGIMSQMNNVGFSTAILLTPVDPTALLDYREVHQMIRELAIGIYCLNQIPSI
SLEANYDQSSSCQLPPAYYDTRIGQILINIDYMLKALWHGIYMPKEKRARFSELWRTIMD
IDADGKPQTNKDIFSEFSSAGLTDITKDPDFNEIYDEDVNEDPTYDPNSPEETAVFMKYA
ENIMLKLTFSTTQVQQYENVFIFETGYWLTNAIKYNQDYLDICTYQRLQQRLYLQKKIIQ
KHFEKKKDIRRGIGYLKLICFLIPFLLSLKKKMKVPYLGSLLQPFSGDDKVKTERELPPF
IYGRDFKCQNFHYEENQYFHVHGGIEFDISTPSIENALEDFQKNLEKIRDCAANTF----
IEDSGYKEYYSIPVMEFHGKSYYVMYFELETFYQQLYKTQWWGAINEIMNNLRPKRLPLT
DAQLHEQFKKKFGFKRAMKCKSIPFGMKSAVERGLSAVFHTFSRKTSSSTINVSDEAGYT
IFHHAALHNRVSIICQLCNANFKVNQRRFVMFG--------------QGPTPLHLAAQAC
SLETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLE----------
AEATAENQCTPLLLAATSGALDTIQYLFSIGANWRKTDTKGNNIIHLSVLTFHTEVLKYI
IKLNIPELPV

PF05804 // ENSGT00680000100065_0_Domain_6 (731, 903)

WKTLVEMLQSESY-KRRMMAVMSLEVICLANDQYWRCILDAGTIPALINL
LKSSKIKLQCKTVGLLSNISTHKRAVRALVEAGGIPSLINLLVCDEPEVHSRCAVILYDI
AQCE-NKDVIAKYNGIPSLINLLNLNIENVLVNVMNCIRVLCIGNENNQRAVREHKGLPY
LIRFLSSDSDVLKAVSSAAIAEVGRDNKEIQDAIAMEGAILPLVALFKGKQISVQMKGAM
AVESLASHNPLIQKAFLEKSLTKYLLKLLKAFQIDVKEQGAVALWALAGQTLKQQKYMAE
QIGYSFIINMLLSPSAKMQYV---GGEAVIALSKDSRMHQNQICEGNGIAPLVRLLRIST
IAEGTLLSVIRAVGSICIGVAHTS----NPVSQQFVVDENAFPVLIQLLRNHPSPNIKVE
V----AFSLACIVLGNDVLQKDLHENEGFEYADVLYLLHSTEKDICLRAGYALTLFAFNN
RFQQYLILESGIMTISIFEPFLESTVETEKAMAAFQIVVLAKVIRDVDHITLSAR--GVT
ILVDSLYSVQTSTIVLTGNLIASL----AHSRAGIPEAFTTLGTIQRLCYHLYSGTEEVR
AACSSALGYLTYNANAFRILFKECRNKPNQFIRIKNNISRDASINPAFLKEFQMQQTLVG
LPSLSLEK---NGGPSIIPIFKKGK----DRRRKLKPKIQPRDSLTLLPPVTNFM----G
LFKATKKTKDSHNI-FSFSSTITSDITN---------------VSRPRIVCLNQLGKHVQ
KANPEPAEG-------------------

MLRLSKKGLP-FDQAQDEQTYLENLAVQRNASAFFENYDRNEIQELITTALASWLSTQED
GHSQLEFPSGIMSQMNNVGFSTAILLMPVDPTALLDYREVHQIIRELAVGIYCLNQIPSI
SLEANYDQSSSCQLPPAYFDTRIGQILIHIDYMLKALWHGIYMPKEKRTRFSEMWRTILD
IDPDGKPQTNKDIFAEFSSAGLVDITQDPDFNGIYDEDMNENPTYNPNSPEEKAVFMKYA
ENILLKLTFSTIQLQQCENVFIFEAAYWLTNAIKSTQDYLDICTYQRLQQRLYLQKKVIQ
KHLEKKKEIRRGISYLKLICFLVPLLLSLKKKMKIPYLNSLLPPFS-DDKVKTERELPPF
IYGRDFKCQNFHYKENQYFHVHGGIEFDITTPSIENALDDFKNNLEKIRACAAKTS----
AEDFGYKEYYSIPVMEFHGKSYYVICFDLEIFYQQLYKTQWWGAINEIVNTLRVKRLPLT
DAQLHEQFKKKFGFKKAMKCKSVPFGLKSAVERGLSAVFHTFSRKTSSSTINVSDEAGYA
IFHHAALHNRISIICHLCDANFNVNQRRFVMLGQ--ESSKMDTKKERNGPTP

PF12796 // ENSGT00680000100065_0_Domain_2 (593, 697)

LHLAAQTC
SLESTICLLSFKADYTLSEKRGWMPIHFAAFYDNICIIIVLCRKDPSLLE----------
AEATAENQCTPLLLAATSGALDTIQYLFSLGANWRKTDTKGNNIIHLSVLTFHTEVLMHI
IELNIPELPVWKTLVEMLQCESL-KRRVMAVMSLEVICLAND

PF00514 // ENSGT00680000100065_0_Domain_5 (763, 800)

RYWKCILEAGTIPALINL
LKSPKIKLQCKTVGLLSNI

ENSGT00680000100065_0_Linker_5_6 (800, 807)

STHGSVV

PF00514 // ENSGT00680000100065_0_Domain_6 (807, 837)

RALVEAGAIPALIALLLSEEPDLQSRCAVILYDI
AQYG-NKDVISKHNGIPALINLLTLDVENVLVNVMNCIRVLCIQNENNQKAVKDHNGIQH
LITFLHTDSDVLQAVSSATIAEVARGNKDVQDAMAEEGAIPALVALFKGKQLSVQTKGAT
AVESLASYNPPIQKAFLENKLTKHLLKLLKAFQIDIKEQGAAALWALAGQTLKQQKYMAE
QIGYNFIINMLLSPSAKMQYV---GGEAVIALSKDSRMHQNQICEGNGIAPLVRLLRINK
IAESTLLSVIRALGSICIGVAHTS----NPVSQQSIVDENAFPVLIQLLRDHPSPTIKVE
V----AFSLACIVLRNDALQKELQDKQGFKYSDVLYLLHSTDKDICLRAGYALTLFAFNN
RFQQYLILESGKITISIFEHFLESTIETEKAMAAFQIIVLAKVIIDVDHITLSAR--GVT
ILVNSLYSDQHITIILA-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------

MLRLPKKGLPRFEQVQDEETYLENLAIQRNASAFFEKYDRSEIQELLTTALVSWLSAKED
VRSQGDLPCGIMSQMNNVGFSTAILLTPVDPTALLDYREVHQMIRELAIGIYCLNQIPSI
SLEANYDQSSSCQLPPAYYDTRIGQILINIDYMLKALWHGIYMPKEKRARFSELWRTIMD
VDADGKPQTNKDIFSEFSSAGLTDITKDPDFNEIYDEDVNEDPTYDPNSPEETAVFMKYA
ENIMLKLTFSTTQVQQYENVFIFETGYWLTNAIKYNQDYLDICTYQRLQQRLYLQKKIIQ
KHFEKKKDIRRGIGYLKLICFLIPFLLSLKKKMKVPYLGSLLQPFS-DDKVKTERELPPF
IYGRDFKCQNFHYKENQYFHVHGGIEFDISTPSIENALEDFQKNLEKIRDCAANTF----
IEDSGYKEYYSIPVMEFHGKSYYVMYFELETFYQQLYKTQWWGAINEIMNNLRPKRLPLT
DAQLHEQFKKKFGFKRAMKCKSIPFGMKSAVESGLSAVFHTFSRKTSSLTINVSDEAGYT
IFHHAALHNRVSIICQLCNANFKVNQRRFVTFG--------------QGPTP

PF12796 // ENSGT00680000100065_0_Domain_2 (593, 697)

LHLAAQAC
SLETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLE----------
AEATAENQCTPLLLAATSGALDTIQYLFSIGANWRKTDTKGNNIINLSVLTFHTEILKYI
IKLNIPELPVWKTLVEMLQSESY-KRRMMAVMSLEVICLAN

PF00514 // ENSGT00680000100065_0_Domain_5 (762, 800)

DQYWRCILDAGTIPALINL
LKSSKIKLQCKTVGLLSNISTHKTAVHALVEAGGIPSLINLLVCDEPEVQSRCAVILYDI
AQCE-NKDVIAKYNGIPSLINLLNLNIENVLVNVMNCIRVLCIGNENNQRAVREHKGLPY
LIRFLSSDSDVLKAVSSAAIAEVGRDNKEIQDAIAMEGAIPPLVALFKGKQISVQMKGAM
AVESLASHNPLIQKAFLEKSLTKYLLKLLKAFQIDVKEQGAIALWALAGQTLKQQKYMAE
QIGYSFIINMLLSPSAKMQYV---GGEAVIALSKDSRMHQNQICEGNGIAPLVRLLRIST
IAEGTLLSVIRAVGSICIGIAHTS----NPVSQQFVVDENAFPVLIQLLRNHPSPNIKVE
V----AFSLACIVLGNDVLQKDLHENEGFEYADVLYLLHSTEKDICLRAGYALTLFAFNN
RFQQYLILESGIMTISIFEPFLESTVETEKAMAAFQIVVLAKVIRDVDHITLSAR--GVT
ILVDSLYSVQTSTIVLTGNLIASL----AHSRAGIPEAFTTLGAIQRLCYHLYSGTEEVR
AACSSALGYLTYNANAFRILLKECRNKPNQFIRIKNNISRDASINPAFLKEFQMQQTLVG
LPSLSLEK---NGGPSIIPIFKKGK----DHRRKLKPKIQPRDSLTLLPPVTNFM----G
LFKATKKTKDSHNI-FSFSSTITSDITN---------------VSRPRIVCLNQLGKHVQ
KANPEPAEG-------------------

MLRLPKKGLPRIDQAQDEQTYLENLAVQRNASAFFENYDRSEIQELLTTALASWLSTKED
GRSQLEFPSGIMSQMNNVGFSTAILLMPVDPTALLDYREVHQIIRELAVGIYCFNQIPSI
SLEANYDQSSSCQLPPAYFDTRIGQILIHIDYMLKALWHGIYMPKEKRTRFSEMWRTIMD
VDPNGKPQTNKDIFAEFSSAGLMDITQDPDFDGIYDEDLNEDPTYDPNSAEEKAVFMKYA
EHILLKLTFSTTQVQQCENIFIFETAYWLTNAIKCTQDYLDVCTYQRLQQRLYLQIKLIQ
KHFEKKKEIRRGIGYLKLICFLVPFLLSLKKKMKFVL------ILE-DDKVKTERELPPF
IHGRDFKCQNFHYKENQYFHVHGGIEFDITTPSIENALDDFKSNLEKIRQCAANTF----
AEDFGYREYYSIPVMEFCGKSYYVIYFELEIFYQQLYKIQWWGAINEIMDTLRVKRLPLT
EAQLHEQFKKKFGLKKAMKCKSIPFGLKSAVERGLSAVFHTFSRKTSSSTINVSDEAGYA
I

PF12796 // ENSGT00680000100065_0_Domain_1 (542, 643)

FHHAALHNRISIICHLCDANFNINQRRFITFSQ-------------RGPTPLHLAAQAC
SLETSICLLSFKADYTLSEKRGWMPIHFAAFYDNISIIIVLYRKDPTVLE----------
AEATAENQCTPLLLAATSGALDTIQYLFSLGANWRKTDTKGNNIIHLSVLTFHTEVLKYI
IQLNIPELPVWKTLVEMLQCEHF-KRRMMAVMSLEVICLAKDQYW

PF00514 // ENSGT00680000100065_0_Domain_5 (766, 800)

KCILDAGTIPALINL
LKSPKIKLQCKTVGLLSNISTHASVVHAMVEAGAIPALINLLVSEEPELHSRSAVILYDI
AQYG-NKDIISKYNGIPALVNLLTLNIENVLVNVINCIRVLCIGNKNNQRAVKDHGGIQH
LIRFLSTDSDVLQASAAAAIAEVARGNKEVQDAMAQEGAVPPLVALFIGKQLSVQIKGAM
AVESLASYNPPIQKAFLEHQLTKYLLKLLKAFQIDIKEQGAVALWALAGQSLKQQKYMAE
QIGYNFIINMLLSSSAKMQYV---GGEAVMALSKDSRAHQNQICEGNGIAPLVRLLRVHK
IAEGTLLSVIRAVGSMCIEVVL-----------------------------------LLS
L----AFSLACIVLGNDGLQKELQEIEGFKYSDVLYLLYSPNKDICLRAAYALTLFAFNN
RFQQYLILESGKITLAIFEPFLESTVETEQAMAAFQIIVLAKVIIDVDHITLSAR--GVT
ILVNSLYSNQYPTIVLTGNLIASL----AHSRAGIPAAFTTLGTVQRLCYHLYSGREEVR
TACSCALGYLTYNAHGFRILLKECRNKPNQFLRIKNNISRDASINPAFLKEFEMQQ-MVG
LPSLSLEK---NGGPSIHPVFKKGKK----HRRKAKPKIQPKDSLTLIPPVTNFM----G
LFKTTKKKTFL-NWYAKVEDGVNISHILMLILNTLFNEKCYKYMKLPKLKCTLL------
----------------------------

MLRLPKKGLTKFDQIQDEETYLENLSVQRNASAFFEKYDRSEVQELLTTALVSWLSTKED
VHSQLDIPCGIMSQMNNVGFSTAILLMPVDPTALLDYREVHQIIRELAVGIYCLNQIPSI
SLEANYDQSSSCQLPPAYYDTRIGQILINVDYMLKALWHGIYMPREKRARFSELWRTIMD
IDPDGKPQTSKDIFAEFSSAGLIDITKDPDFNGIYDEDMNEDPTYDPNSPEEKKVFMKYA
ENIMLKLTFSTTQIQQYKNVFIFETAYWLTNAIKYNQDYLDICTYQRLQQRLYLQKKIIQ
KHFEKKNEIRRGIGYLKLICFLIPFLLSLKKKMKVPYLNSLLPPFS-DDKVKTERELPPF
IYGRDFKCQHFHYNENKYFHVHGGIEFDISTSPIENALEDFKNNLEKIRDCAAKTF----
VEDSGYKEYYSIPVMEFNGKSYYVINFELEIFYQQLYKTQWWGAINEIINNLRVKRLPLT
DAQLHEQFKKKFGFKKSMKCKSIPFGMKSAVERGLTAVFHTFSRKTSSSTINVSDEAGYT
I

PF12796 // ENSGT00680000100065_0_Domain_1 (542, 638)

FHHAALHNRVSIICQLCNANFNVNQRRFITFN--------------QGPTPLHLAAQAC
SLETTICLLSFKADYTLSEKRGWMPIHFAAFYDNICIIIALYRKDPSLLE----------
AEATAENQCTPLLLAATSGALDTIQYLFSLGANWRKTDNKGNNIIHLSVLTFHTEVLKHI
IELNIPELPVWKTLVEMLQCESY-KRRMMAVMSLEVICLA

PF00514 // ENSGT00680000100065_0_Domain_5 (761, 800)

NDQYWKYILDAGTIPALINL
LKSSKIKLQCKTVGLLSNISTHASIVHALVEAGGIPALINLLAYDEPELHSRCAVILYDI
AQCE-NKDVIAKYNGIPGLINLLKLDIESVLVNVMNCIRVLCIGNENNQREVRNHKGIQH
LVRFLNSDSDVLKAVSSATIAEVGRDNREIQNAIAMEGGIPPLVALFKGKQLDVQMKGAM
AVESLASGNPLIQKAFLEKSLTKYLLKLLKAFQIEVKEQGAVALWALAGQTLKQQKYMAE
QIGYNFIINMLLSPSAKMQYV---GGEAVIALSKDSRMHQNQICEGNGIAPLVRLLRISK
IADGTLLSVIRAVGSICIGVAHTS----NPVSQQFIVEENAFPVLIQLLRNHPSPNIKVE
V----AFSLACIVLRNDSFQKDLHENEGFEYADVLYLLHSTDKDICLRAGYALTLFAFNN
RFQQYLILERGTMTISIFEPFLESTVETEKAMAAFQIIVLAKVIIDVDHITLFAR--GVT
ILVDSLYSVQTSTIVLTGNLIASL----AQSRNGIPEAFTTLRIIQRLCYHLYSGIEEVR
AACSCALGYLTYNANAFRILLKECRNKPNQFLRLTNNISRDASINPAFLKEFQMQR-TVG
LPSLSLEK---NGGPSIIPVFKKGK----EHRRKSKSKIQPRDSLTLIPPITNFM----G
LFKATKKTKVSHNI-FSFSSAITSDIIN---------------VSRPRIVSLNQLGKHVQ
KANPEPAEG-------------------

MDKYRSVKMVASKPPVKDETFIAEMSLQRNAHAFFERFSQSEIQELLVYTTSSWLANMED
I--QFQLPSGLICQMKNQCNSSVFLLAPVESEVRLDYRDVHQIIRELAVGIYCFNQVPSI
SLDANYDRSTSCNIPPAYCDTRVGQIMIAVDYMMKALWHGAFMAKDKRVRFSEFWRSNMN
IDANGIPLTKKDVFADFCAAGLTDISSDPDYEDIYSQTPDFDPSYEPNNEEEKNLFMQYA
DSITIKMTCFITDVQQCENFFIYDASNQFSTAIRLTEEYIDPVTYQRLQQRLKIQRKLVA
ENIEKTVENRKNVAYLKLISFLVPFFLGLKKKMKVPDLNHLLQPFS-NDKLKTERELPPL
MLGENFACQHFQYGENEYFHLHGGIEFDLGTPSLEQPCEDIKASCKQRKPLSISV--SRE
DLDTTYREYYPIPTVTINGKSYYTIAIQLENFYPAGLKTHWWGAINGIISTLKPKRLPLT
DVQMYEQFKKRFGYKRAIKCQNFPFGLKSAAKRGLAAVFHTFSRKTQISGLDVRDE

PF00023 // ENSGT00680000100065_0_Domain_0 (537, 569)

AGYA
VIHHAAIYNRVVIVSQLAKASFNLNQRR

ENSGT00680000100065_0_Linker_0_1 (569, 588)

NIILNDNHFC-SLFFKELL

PF00023 // ENSGT00680000100065_0_Domain_1 (588, 620)

LGPTALHIAAQCG
SLEVLLCLLALKTDYMLRD

ENSGT00680000100065_0_Linker_1_2 (620, 621)

N

PF00023 // ENSGT00680000100065_0_Domain_2 (621, 663)

RGWMAIHFAAFYGAIPCIRALYRNDPNLLE----------
ME

ENSGT00680000100065_0_Linker_2_3 (663, 667)

TTAQ

PF00023 // ENSGT00680000100065_0_Domain_3 (667, 699)

YQCTPLLLTAAAGELDALHYLLSVGANWKQKD

ENSGT00680000100065_0_Linker_3_4 (699, 700)

S

PF00023 // ENSGT00680000100065_0_Domain_4 (700, 722)

LGNNIIDLAVLYFHTNILKYI
I

ENSGT00680000100065_0_Linker_4_5 (722, 761)

DLNIPELHVWQQLAGLLKCDDQ-HRKEMAVRCLEVLCVV

PF00514 // ENSGT00680000100065_0_Domain_5 (761, 801)

NRNYWEDIYKAGTIPSLVEL
LHSDQVPLKCLALGILSNIS

ENSGT00680000100065_0_Linker_5_6 (801, 802)

N

PF00514 // ENSGT00680000100065_0_Domain_6 (802, 842)

NNPVSRALVKSGAIQVLVHLLHSRQPELQSRCSVLLSDI
A

ENSGT00680000100065_0_Linker_6_7 (842, 843)

Q

PF00514 // ENSGT00680000100065_0_Domain_7 (843, 883)

IDSNQNVIAEMDGISPLVHLLYEKYEDVLVNAVNCIRVLC

ENSGT00680000100065_0_Linker_7_8 (883, 885)

IK

PF00514 // ENSGT00680000100065_0_Domain_8 (885, 925)

NTANQKAVRDLGAIPS
LVEFLTAKSDILVSAATDVIAELA

ENSGT00680000100065_0_Linker_8_9 (925, 927)

RD

PF00514 // ENSGT00680000100065_0_Domain_9 (927, 967)

NKAIQDAVTKEGVIESLISILRVRNINIQVKAAM
TIEALC

ENSGT00680000100065_0_Linker_9_10 (967, 1109)

DHNPAVQKEFLTKSVTKHISKLLKVFQLEVREQGSTTLWALAGQTRKQQKAMAE
YIGYKCIIDMLLSPSDKMQYIEFKGGEAIIALCKDSRHYQCQICEGNGIGPLVRLLRSPK
VANGTLIRIIKALGIMCIGVAFIN----

PF00514 // ENSGT00680000100065_0_Domain_10 (1109, 1154)

NPVAQEKIVEENAIPTLLHLLKTQNSLHVKAE
V----ACTLACIV

ENSGT00680000100065_0_Linker_10_11 (1154, 1302)

LRNSNLQDSLKEMEDVKYSDILDLLYASDKAICLRAGYALSLFAYSS
TMQQFNILENGGIKISIYEPFLQSDIEPERALAAFQIVVLAKVISDMDQITLCTK--GVT
VLTELLQSKNPTTLVLTGELLATL----AHIRTGIPEAITT

PF02985 // ENSGT00680000100065_0_Domain_11 (1302, 1334)

LGTVKCLCNHLYSPDEEVR
IACANALGYLTFNRTASRHLLAECRTRPCLYNLLISNLSEDARMSKTFTDEFKIQK-QIG
LPSLRL------------------------------------------------------
------------------------------------------------------------
----------------------------

MLRFPKKGLTKYDQIQDEETYLENLSVQRNAFAFFERYDRSEVQELLTTALVSWLSTKED
VQSQLDLPCGIMSQMNNVGFSTAILLMPVDPAALLDYREVHQIIRELAVGIYCLNQIPSI
SLEANYDQSSSCQLPPAYYDTRIGQILINVDYMLKALWHGIYMPREKRARFSELWRTIMD
IDPDGKPQTSKDVFTEFSSAGLIDITKDPDFNGIYDEDMNEDPTYDPNSPEEKDVFMKYA
ENIMLKMTFSTTQIQQYENVFIFETAYWLTNAIKCNQDYLDICTYQRLQQRLYLQKKIIQ
KHFEKKNEIRRGIGYLKLICFLIPFLLSLKKKMKVPHLNSLLPPFS-DDKVKTERELPPF
IYGRDFKCQHFHYKENKYFHVHGGIEFDISTSSIENALEDFKNNLEKIRNCAANKC----
VEDSGYKEYYSIPVMEFKGKSYYVINFELEIFYQQLYKTQWWGAINEIMNNLRVKRLPLT
DAQLHEQFKKKFGFKKSMKCKSIPFGMKSAVERGLTAVFHTFSRKTSSSTINVSDEAGYT
I

PF12796 // ENSGT00680000100065_0_Domain_1 (542, 642)

FHHAALHNRVSIICQLCKANFNVNQRRYIMFN--------------QGPTPLHLAAQAC
SLETTVCLLSYKADYTLSEKRGWMPIHFAAFYDNICIVIALYRKDPSLLE----------
AEATAENQCTPLLLAATSGALDTIQYLFSLGADWRKTDNKGNNIIHLSVLTFHTEILKHI
IELNIPELPVWKTLVEMLQCESY-KRRMMAVMSLEVICLA

PF00514 // ENSGT00680000100065_0_Domain_5 (761, 800)

NDQYWKYILDAGTIPALINL
LKISKIKLQCKTVGLLSNISTHTSVVHALVEAGGIPALINLLDYDEPELHSRCAVILYDI
AQCE-KKNVIAKSNGIPGLIKLLKLDIENVLINVMNCIRVLCIGNENNQRAVRDHKGIQH
LVRFLSSDSDVLKAVSSATIAEVGRANKEIQNAIAMEGGIPPLVALFKGNQLNVQMKGAM
AVESLASGNPLIQKAFLEKSLTKYLLKLLKAFQIDVKEQGAVALWALAGQTLKQQKYMAE
QIGYNFIINMLLSPSAKMQYV---GGEAVIALSKDSRMHQNQICEGNGIAPLVRLLRISK
VAEGTLLSVIRAVGSICIGVAHTS----NPVSQQFIVEENAFPVLIQLLRNHPSPNIKVE
V----AFSLACIVLRNDLFQKDLHENEGFEYADVLYLLHSKDKDICLRAGYALSLFAFNN
RFQQYLMLERGTMTISIFEPFLASRIETEKAMAAFQIIVLAKVIIDVDHITLFAR--GVT
ILVDSLYSVHTSTIVLTGNLIASL----ARSRGGIPEAFTTLGTIQRLCYHLYSGREEVR
AACSCALGYLSYNANAFRILLKECRNKPNQFLRLTNNISRDASINPAFLKEFQIQQ-TVG
LPSLSLEK---NGGPS-------RK----EHRGKSKSKIQPRDSLTLLPPRTNLM----G
RFRVTKKTKVSQNI-FSFSSAITSDIIN---------------VSRPRIVCLDQLGKHVQ
KVNSEPAEG-------------------

MLRFPKKGLAKFDQS-DQTTFLSNLAVKRNASAFFEKYDRNEIQELLATAVISWLSGKED
VRSLIELPDGLMSHLKSVGFSTAIVLAPVDPNANLDYREVHQIVRELSIGIYCLNQIPSI
SLEFNYDQSSSCQLPSAYFDTRIGQILINVDYMIKSLWHGIYMPKDKRMRFSEMWRSLMD
IDVEGKPQTDKDIFAEFCSAGLLDLTKDPDYEGIYDEDMNEDPTYDPNSPEEKSIFMKYI
ENIKLKLTFSNTLVQQYENVFLFEAASWLTNVIRYTDDFLDICTYQRLQQRLALQKKLIE
KHLEKKYEMRQNMAYLRLICFMIPFLLALKRKMKVPNLNTLLPAFSD-DKVKTERELPPF
IRGQNFKCQHFHYAQNQYFHVHGGVEFDIGTPSVEEITEPFKDIYDYLQEITSEPV----
-SNVGYKEYYPIPVIQHNGKSYYVISFDLEAFYLQLYKTQWWGAITEIMDGLRPKRLPLS
DIQLHEQFKKKFGFKKAMKCKSLPYGMKCTVERGLYAAFHTFCRKTSSATINVIDDLGYS
ILHHASMHNKVPIICQLCSANVNVNQRRYVTSSQGRDAPKSDMKKDRT

PF00023 // ENSGT00680000100065_0_Domain_1 (589, 614)

GITALHLAAQAG
SLEATNCLLSHKADYTLYEKRGWMPIHFAAFYDNICIIIVLCRKDANLLE----------
VETASEQRCTPLLLAATSGALDTLHYLFSHGANWRKTDSKGNNIIHLSVLNFHTEILKHI
IVLNIPELPVWKTLVEMLVSDNY-KRKMMAVMSLEVICLASENYW

PF00514 // ENSGT00680000100065_0_Domain_5 (766, 800)

KCILDAGTIPALIHL
LKSHKLQLKCKITGLLSNISTHRSVCHALVEAGGIPVLINLLHFDEPELQARSAVILYDV
AQIEIYKRIIAKHNGMPALISLLKSDKDFLLLNVMNCMRVLCIGYPENQKAVKDHKGIPY
LVSFLSSESDVLQAVSSAAIAEIARGNPDMQEAIAREGAIMPLVALFKGKQISVQVKGAM
AVESLASHNGAIQRGFLEKSLTKYLLKLLKAFHIPVKEQGATALWALAGQSLKQQKFMAE
QIGYNFIIDMLLSPSAKMQYV---GGEAVIALSKDSKVHQNQICEGNGIAPLVRLLRISK
IAVGTLLSVIRAVGTICIGVAHTN----NATSQQYIVDEQAFPVLIQLLRNHPSVQIKVE
V----ACALACIVLKNNKLQDILQEKEGFRYDDVLYLLHSPEKEICLRAGYAITLFAFNN
CYQQYLILESGAITLSIFEPFLNSEIETEQAMAAFQIIVLAKVIVDADHITLSAR--GIT
ILVDLLYSCRTATLVLTGNLIASL----THTRAGLIEAFSTLRTIQRLCHHLYSEKEEVR
ISCACALGYLTYNAKAYRYLLKECRNKPNQFLRLMNNLSKDATICPDFVKEFQMQR-KIG
LPSLSLEI---NGGPSIIPVFKKGK----EHRRKAKAKIQPKDSLLLIPHTGNLI----G
RLKASKFTTSRK--IITFSTSDSTDIIK---------------VSRPRIVTLSKLKIKQK
KAAQDTQGNPYKP-IQYENIG-------

MSRIVKKGIVKIDQEQDEETFRENLAVQRNASAFFEKYDRTEVQELLTTTLVSWLAAKDD
ARSQLETPCGLMSQMNNAGFSTAILLTPVDPTALLDYREVHQILRELAIGIYCLNQIPSI
SLEANFDQSSSCQLPPAYYDTRVGQILIQIDYMLKALWHGIYMPKEKRARFSELWRTIMD
IDLDGKPQTTKNVFSEFSSAGLVDITNDPDFNGIYDEDMNEDPTYEPNSPEEKAVFMKYA
ESIMMKLTFSTVQIQQHENIFIFETAYWLSNAIKYNQDYLDICTYQRLQKRLYLQKKVIQ
KHFEKKKEIRRGMGYLKLICFLIPFLLSLKRKMKVPYLNSLLPPFS-DDKVKTERELPPF
IYGRDFKCQNFDYKQHQYFHVHGGIEFDISTHPVESALDEFKKNVEKIWECASSAS----
AEDAGYKEVYPIPVMELNGKSYYVIHFELEIFYQQLYKTQWWVAINETVNNLKVKRLPLT
EDQLHEQFKKKFGLKKAMKCKSIPFGVKSAVERGLSAVFYTFSRKTSSSTINVSDEAGYA
IFHHAALHNRVSVICQLWSANFNVNQRRFIMFSQA-DSSKVDMKKERNGPTPLHLAAQAC
SLEATICLLCFKADYTLTEKRGWMPIHFAAFYDNICILIALCRKDPSLLE----------
AEATAENQCTPLLLAATSGALDTIQYLFSLGANWRKTDTKGNNIIHLSVLAFHTEVLKYI
IELNIPELPVWETLVEMLQCESS-KRRMMAVMSLEVICLAN

PF00514 // ENSGT00680000100065_0_Domain_5 (762, 800)

DRYWQCILDAGTIPALVNL
LKSPQIKLQYKTVGLLSNISTHVSIVHAIVEAGGIPAVINLLTSDEPELHSRCAIILYDV
AKCE-NKDVIAKYSGIPALINLLSLNKESVLVNVMNCIRVLCMGNESNQQSMKDNNGIQY
LIQFLSSDSDVLKALSSATIAEVARDNKEVQDAIAKEGAIPPLVTLFKGKQLSVQVKGAM
AVESLANCNPLIQKEFLERELTKDLLKLLQAFQIDVKEQGAIALWALAGQTLKQQKYMAE
QIGYNLIISMLLSPSAKMQYV---GGEAVIALSKDSRMHQNQICEGKGIAPLVRLLRINK
IPEGTLLSVIRAVGSICIGVAHTS----NPMSQQFVVEENALPVLIQLLRNHPSINIRVE
V----AFSLACIVLGNNSLKKELQNDEGFEYSDVLYLLHSKDKEVCLKAGYALTLFAFND
RFQQHLILETGLITVSIFEPFLQSSVETERAMAAFQIIILAKAIIDVEHVTLYGR--GIQ
ILADSLNSVHAPTIALTGNIIASL----AHSRAGIPEAFVSLGTVQRLCYHLYARSEEVR
TACSCALGYLTYNAHAFRLLLTECRNKPNQFLRITNNISKDAKINPAFLKEFQLQQ-RMG
LPSLSLER---NGGPPVIPVFKKGK----EHRQKTRPKIQPRDSLTLLPPVTNVK----E
LFRTTHKANISHNT-FSFPSGVSSDIIN---------------VSRPRIAFLNKLGKDEQ
KANPDPPAFLNKLGKDEQNANPDPAESQ

MLRLPKKGAPRFDQNQDEETYLENLAVQRNASAFFEKYDRSEVQELLTTALVSWLSAKED
VRSQLDMPCGIMSQMNNVGFSTAILLTPVDPTALLDYREVHQIIRELAVGIYCLNQIPSI
SLEANYDQSSSCQLPPAYFDTRIGQILINIDYMLKALWHGIYMPKEKRARFSELWRTIMD
IDPDGKPQTNRDIFAEFSSAGLIDITKDPDFDGIYDEDMNDDPTYNPNSPEEKAVFMKYA
EYILLKMTFSTTQVQQCENVFIFETAYWLTNAIKCNQDNLDICTYQRLQQRLYLQKKIIQ
KHFEKKKEIRKGIGYLKLICFLTPFLLSLKKKMKVPYLSGLLQPFS-DDKVKTERELPPF
IYGRDFKCQNFHYKEDQYFHVHGGIEFDISTPSIENALEDFKNNLEKIRDCAVNAL----
AEDSGYKEHYSIPVVKFNGKSYYVISFELEIFYQQLYKTQWWGAINEIVNNLRLKRLPLT
DAQLHEQFKKKFGFKKAMKCKSIPFGMKSAVERGLYAVFHTFSRKTSSSTINISDEAGYA
IFHHAALHNRVPIICQLCNANFNVNQRRFIILNQE-SS-KVDMKKERNGPTPLHLAAQTC
SLETTICLLCFKADYTLSEKRGWMPIHFAAFYDNICIIIVLCRKDPSLLE----------
AEATADNQCTPLLLAATSGALDSIQYLLSLGANWRKTDIKGNNIIHLSVLTFHTEVLKHI
IELNIPELPVWKTLVEMLQCESY-KRRMMAVMSLEVICLA

PF00514 // ENSGT00680000100065_0_Domain_5 (761, 800)

NDEYWKCILDAGTIPALINL
LKGSKIKLQCKTVGLLSNISTHPSIVHALVEAGAIPALINLLVSEEPELHSRCAVILYDI
AQLE-NKDVIAKHNGIPALINLLNLDIESVLVNVMNCMRVLCMGNKNNQRAVKDHKGIPY
LISFLSSDSDMLTAVSSVTIAEVARDNKEVQDAMALEGAIPPLVALFKGKQLSVQVKGAM
AVEALASHNPAIQRAFLEKSLSKCLLKLLKAFQIDVKEQGAVALWALAGQTLKQQKYMAE
QIGYNFIINMLLSPSAKMQYV---GGEAVIALSKDSKIHQNQICEGNGIAPLVRLLRISK
IADGTLLSVIKAVGSICIGVAHTS----NPVSQQFVVDENAFPVLIQLLRNHPSPNIKVE
V----AFSLACIVLRNDLLQKELQENEGFDYADVLYLLHSEDKNICLRAGYALTLFAFNN
RFQQYLILENGKMSISIFEPFLESTIETEKAMAAFQIIVLAKVIIDVDHITLTAR--GVT
ILVDSLYSADSSTIVLTGNLIATL----AHSRAGIPEAFTTLGTVQQLCYHLYSGQEEVR
MACSSALGYLTYNANAFRLLLKECRNKPNQFLRITNYISRDASINPAFLKEFEMQQ-KVG
LPSLSLEK---NGGPSIIPVFKKGK----EHRRKLKPKVQPRDSLTFIPPVTNFM----G
LFKTTKKTTVSHNI-FSFSSAISSDIIT---------------VSRPRIVLLNQLGKHVQ
KANPEPGEEKKNFNITI-----------

MSRIVKKGIVKIDQEQDEETFRENLAVQRNASAFFEKYDRTEVQELLTTTLVSWLAAKDD
ARSQLETPCGLMSQMNNAGFSTAILLTPVDPTALLDYREVHQILRELAIGIYCLNQIPSI
SLEANFDQSSSCQLPPAYYDTRVGQILIQIDYMLKALWHGIYMPKEKRARFSELWRTIMD
IDLDGKPQTTKDVFSEFSSAGLVDITNDPDFDGIYDEDMNEDPTYEPNSPEEKAVFMKYA
ESMMMKLTFSTIQIQQHENIFIFETAYWLSNAIKYNQDYLDICTYQRLQKRLYLQKKVIQ
KHFEKKKEIRRGMGYLKLICFLIPFLLSLKRKMKVPYLNSLLPPFS-DDKVKTERELPPF
IYGRNFKCQNFDYKQHQYFHVHGGIEFDISTHPVESALDEFKKNVDKIWECASSAF----
AEDSGYKEVYPIPVMELNGKSYYVIHFELEIFYQQLYKTQWWVAINETVNNLKVKRLPLT
EDQLHEQFKKKFGLKKAMKCKSIPFGVKSAVERGLSAVFYTFSRKTSSSTINVSDEAGYA
IFHHAALHNRVSVICQLWSANFNVNQRRFIMFSQA-DSSKVDMKKERNGPTPLHLAAQAC
SLEATICLLCFKADYTLTEKRGWMPIHFAAFYDNICILIALCRKDPSLLE----------
AEAAAENQCTPLLLAATSGALDTIQYLFSLGANWRKTDTKGNNIIHLSVLAFHTEVLKYI
IELNIPELPVWETLVEMLQCESS-KRRMMAVMSLEVICLAN

PF00514 // ENSGT00680000100065_0_Domain_5 (762, 800)

DRYWQCILDAGSIPALVNL
LKSPQIKLQYKTVGLLSNISTHVSIVHAIVEAGGIPAVINLLTSDEPELHSRCAIILYDI
AKCE-NKDVIAKYSGIPALINLLSLNKESVLVNVMNCIRVLCMGNESNQQSMKDNNGIQR
LIQFLSSDSDVLKALSSATIAEVARDNKEVQDAIAREGAIPPLVTLFKGKQLSVQVKGAM
AVESLANCNPLIQKEFLERELTKDLLKLLQAFQIDVKEQGAIALWALAGQTLKQQKYMAE
QIGYNLIISMLLSPSAKMQYV---GGEAVIALSKDSRMHQNQICEGKGIAPLVRLLRINK
IPEGTLLSVIRAVGSICIGVAHTS----NPMSQQFVVEENALPVLIQLLRNHPSINIRVE
V----AFSLACIVLGNNSLKKELQNDEGFEYSDVLYLLHSKDKEVCLKAGYALTLFAFND
RFQQHLILEIGLITVSIFEPFLQSSVETERAMAAFQIIILAKAIIDVDHVTLYGR--GIQ
ILADSLNSVHAPTIALTGNIIASL----AHSRAGIPEAFVSLGTVQRLCYHLYARSEEVR
TACSCALGYLTYNAHAFRLLLTECRNKPNQFLRITNNISKDAKINPAFLKEFQLQQ-RMG
LPSLSLER---NGGPPVIPVFKKGK----EHRQKARPKIQPRDSLTLLPPVTNVK----E
LFRTTHKANIAHNT-FSFPSGVSSDIIN---------------VSRPRIAFLNKLRKDEQ
KANPDPPAFLNKLGKDEQNANPDSAESQ

MFRISKKGIVRFDQVQDEETYLENLAVQRNASAFFEKYDRSEVQELLTTALVSWLSTKDD
VRSQLDIPCGLMSQINNVGFSNAILLTPVDPTAHLDYREVHQILRELAVGIYCLNQIPSI
SLEANYDQSSSCQLPPAYYDTRIGQILIHIDYMLKALWHGIYMPKEKRTRFSELWRTIMD
IDPDGKPQTTKDIFSEFSSAGLVDITNDPDFNGIYDEDMNEDPTYDPNSPEEKAIFMKYA
ENIMLKLTFSTTRVQQHENIFIFETAYWLTNAIKYNQDYLDICTYQRLQQRLYLQKKVIQ
KHFEKKKEIRRGIAYLKLICFLIPFLLSLKKKMKVPYLNSLLPPFS-DDKVKTERELPPF
IYGRDFKCQNFDYKEHQYFHVHGGIEFDISTNPVESALDEFKENVGNIRECAANPF----
AEDSGYKEFYSVPVMEFYGKSSSPGPCGNVAKVE----PHS----CDSVNTFYVLFF---
--SFKENFIIIF-TKLFKTTDSIPFGMKSAVERGLSAVFHTFSRKTSSSTINVSDEAGYA
I

PF12796 // ENSGT00680000100065_0_Domain_1 (542, 642)

FHHAALHNRVSIICQLCNANFNVNQRRFIMFSQ--DSSKGDTKKERNGPTPLHLAAQAC
SLETTICLLSFKADYTLTEKRGWMPIHFAAFYDNICIIIALCRKDPSLLE----------
AEATAENQCTPLLLAATSGALDTIQYLFSLGANWRKTDIKGNNIIHLSVLTFHTEVLKYI
IELNIPELPVWKTLVEMLQCESF-KRRMMAVMSLEVICLAND

PF00514 // ENSGT00680000100065_0_Domain_5 (763, 800)

RYWKCILDAGTIPALINL
LKCPKIKLQVKTVGLLSNISTHVSVVHSLVEAGGIPALINLLSSEEPELHSRCAVILYDI
AKCE-NKDVIAKYNGIPALINLLSLDIENVLVNVMNCIRVLCMGNEGNQRAMKDHNGIQH
LIRFLSSDSDALKAVSSATIAEVGRDNKEVQDAIAMEGAIPPLVDLFKGKQLSVQVKGAM
AVESLANCNPLIQKAFLERQLTKDLLKLLKAFQLDVKEQGAIALWALAGQTLKQQKYMAE
QIGYNFIINMLLSPSAKMQYV---GGEAVIALSKDSRVHQNQICEGNGIAPLVRLLRINK
IAEGTLLSVIRAVGSICIGVAHTS----NPMSQQFVVEENAFPVLIQLLRSHPSVNIKVE
V----AFSLACIVLGNDLLQKELQEKEGFMYSDVLYLLHSKDKEICLRAGYALTLFAFNN
RFQQYLILESGMITISIFEPFLRSTVETERAMAAFQIIVLAKVIIDVDHITLSAR--GVT
ILVDSLYSAHTPTIVLTGNLIASL----AHSRVGIPDAFMTVGTIQRLCYHLYSGREEVR
TACSCALGYLTYNAYAFRILLSECRNKPNQFLRITNNISRDAKINPAFLKEFQMQQ-SVG
LPSLRYCAFIRNGSSEVISTYTRS------------TRITPTDKLSNNGETTNSPSMMIR
LMTTL-------------------------------------------------------
----------------------------

MLRLPKKGLPRFEQVQDEDTYLENLAIQRNASAFFEKYDRSEIQELLTTALVSWLSAKED
VRSQVDLPCGIMSQMNNVGFSTAILLTPVDPTALLDYREVHQMIRELAIGIYCLNQIPSI
SLEANYDQSSSCQLPPAYYDTRIGQILINIDYMLKALWHGIYMPKEKRARFSELWRAIMD
IDPDGKPQTNKDIFSEFSSAGLTDITKDPDFNEIYDEDVNEDPTYDPNSPEETAVFMKYA
ENIMLKLTFSTTQIQQYENVFIFETGYWLTNAIKYNQDYLDICTYQRLQQRLYLQKKIIQ
KHFEKKKDIRRGIGYLKLICFLIPFLLSLKKKMKVPYLSSLLQPFS-DDKVKTERELPPF
IYGRDFKCQNFHYKENQYFHVHGGIEFDISTPSIENALEDFQKNLEKIRDCAANTF----
IEDSGYKEYYSIPVMEFHGKSYYVIYFELETFYQQLYKTQWWGAINEIVNNLRLKRLPLT
DAQLHEQFKKKLGFKRAMKCKSIPFGMKSAVERGLSAVFHTFSRKTSSSTINVSDEAGYT
IFHHAALHNRVSIICQLCNANFKVNQRRFVTFS--------------QGPTPLHLAAQAC
SLETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPRLLE----------
AEATAENQCTPLLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYI
IKLNIPELPVWKTLVEMLQCESY-KRRMMAVMSLEVICLAN

PF00514 // ENSGT00680000100065_0_Domain_5 (762, 800)

DQYWRCILDAGTIPALINL
LKSSKIKLQCKTVGLLSNISTHKSAVHALVEAGGIPSLINLLVCDEPEVHSRCAVILYDI
AQCE-NKDVIAKYNGILSLINLLNLNIENVLVNVMNCIRVLCIGNENNQRAVREHKGLPY
LIRFLSSDSDVLKAVSSAAIAEVGRDNKEIQDAIAMEGAIPPLVALFKGKQISVQMKGAM
AVESLASHNALIQKAFLEKSLSKYLLKLLKAFQIDVKEQGAVALWALAGQTLKQQKYMAE
QIGYSFIINMLLSSSAKMQYV---GGEAVIALSKDSRMHQNQICEGNGIAPLVRLLRIST
IAEGTLLSVIRAVGSICIGVAHTS----NPVSQQFVVDENAFPVLIQLLRNHPSPNIKVE
V----AFSLACIVLGNDVLQKDLHENEGFEYADVLYLLHSTEKDICLRAGYALTLFAFNN
RFQQYLILESGIMTISVFERFLESTVETEKAMAAFQIVVLAKVIRDMDHITLSAR--GVT
ILVDSLYSVQTSTIVLTGNLIASL----AHSRAGIPEAFTTLGTIQRLCYHLYSGIEEVR
AACSSALGYLTYNANAFRILLKECRNKPNQFIRIKNNISRDASINPAFLKEFQMQQTLVG
LPSLSLEK---NGGPSIIPIFKRGK----EHRRKLKPKIQPKDSLTLLPPVTNFM----G
LFKATKKTKDSHNI-FSFSSTITSDITN---------------VSRPRIVCLNQLGKHVQ
KANPEPAEG-------------------

MLRLPKKGLPRFEQVQDEETYLENLAIQRNASAFFEKYDRSEIQELLTTALVSWLSAKED
VRSQVDLPCGIMSQMNNVGFSTAILLTPVDPTALLDYREVHQMIRELAIGIYCLNQIPSI
SLEANYDQSSSCQLPPAYYDTRIGQILINIDYMLKALWHGIYMPKEKRARFSELWRTIMD
IDPDGKPQTNKDIFSEFSSAGLTDITKDPDFNEIYDEDVNEDPTYDPNSPEETAVFMKYA
ENIMLKLTFSTTQVQQYENVFIFETGYWLTNAIKYNQDYLDICTYQRLQQRLYLQKKIIQ
KHFEKKKDIRRGIGYLKLICFLIPFLLSLKKKMKVPYLSSLLQPFS-DDKVKTERELPPF
IYGRDFKCQNFHYKENQYFHVHGGIEFDISTPSIENALEDFQKNLEKIRDCAANTF----
IEDSGYKEYYSIPVMEFHGKSYYVIYFELETFYQQLYKTQWWGAINEIVNNLRLKRLPLT
DAQLHEQFKKKFGFKRAMKCKSIPFGMKSAVERGLSAVFHTFSHTTSSSTINVSDEAGYT
I

PF12796 // ENSGT00680000100065_0_Domain_1 (542, 642)

FHHAALHNRVSIICQLCSANFEVNQRRFVTFS--------------QGLTPLHLAAQAC
SLETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLE----------
AEATAENQCTPLLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYI
IKLNIPELPVWKTLVEMLQCESY-KRRMMAVMSLEVICLAN

PF00514 // ENSGT00680000100065_0_Domain_5 (762, 800)

DQYWRCILDAGTIPALINL
LKSSKIKLQCKTVGLLSNISTHESAVHALVEAGGIPSLINLLVCDEPEVHSRCAVILYDI
AQCE-NKDVIAKYNGIPSLINLLNLNIENVLVNVMNCIRVLCIGNENNQRAVREHKGLPY
LIRFLSSDSDVLKAVSSAAIAEVGRGNKEIQDAIAMEGAIPSLVALFKGKQISVQMKGAM
AVESLASHNPLIQKAFLEKSVTKYLLKLLKAFQIDVKEQGAVALWALAGQTLKQQKYMAE
QIGYSFIINMLLSPSAKMQYV---GGEAVIALSKDSRMHQNQICEGNGIAPLVRLLRIST
IAEGTLLSVIRAVGSICIGVAHTS----NPVSQQFVVDENAFPVLIQLLRNHPSPNIKVE
V----AFSLACIVLGNDVLQKDLHENEGFEYADVLYLLHSTEKDICLRAGYALTLFAFNN
RFQQYLILESGIMTISIFERFLESTVETEKAMAAFQIVVLAKVIRDVDHITLSAR--GVT
ILVDSLYSVQTSTIVLTGNLIASL----AHSRAGIPEAFTTLGTIQRLCYHLYSGIEEVR
AACSSALGYLTYNANAFRILLKECRNKPNQFIRIKNNISRDASINPAFLKEFQMQQTLLG
LPSLSLEK---NGGPSIIPIFKKGK----EHRRKLKPKIQPKDSLTLLPPVTNFM----G
LFKATKKTKDSHNI-FSFSSTITSDITN---------------VSRPRTVCLNQLGKHVQ
KANPEPAEG-------------------

MLRLPKKGLPRFEQVQDEETYLENLAIQRNASAFFEKYDRSEIQELLTTALVSWLSTKED
VRSQGDLPCGIMSQMNNVGFSTAILLTPVDPTALLDYREVHQMIRELAIGIYCLNQIPSI
SLEANYDQSSSCQLPPAYYDTRIGQILINIDYMLKALWHGIYMPKEKRARFSELWRTIMD
IDADGKPQTNKDIFSEFSSAGLTDITKDPDFNEIYDEDVNEDPTYDPNSPEETAVFMKYA
ENIMLKLTFSTTQVQQYENVFIFETDYWLTNAIKYNQDYLDICTYQRLQQRLYLQKKIIQ
KHFEKKKDIRRGIGYLKLICFLIPFLLSLKKKMKVPYLGSLLQPFS-DDKVKTERELPPF
IYGRDFKCQNFHYKENQYFHVHGGIEFDISTPSIENALEDFQKSLEKIRDCAANTF----
IEDSGYKEYYSIPVMEFHGKSYYVMYFELETFYQQLYKTQWWGAINEIMNNLRPKRLPLT
DAQLHEQFKKKFGFKRAMKCKSIPFGMKSAVERGLSAVFHTFSRKTSSSTINVSDEAGYT
IFHHAALHNRVSIICQLCNANFKVNQRRFVTFG--------------QGPTP

PF12796 // ENSGT00680000100065_0_Domain_2 (593, 697)

LHLAAQAC
SLETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIVIALCRKDPSLLE----------
AEATAENQCTPLLLAATSGALDTIQYLFSIGANWRKTDTKGNNIIHLSVLTFHTEVLKYI
IKLNIPELPVWKTLVEMLQSESY-KRRMMAVMSLEVICLAN

PF00514 // ENSGT00680000100065_0_Domain_5 (762, 800)

DQYWRCILDAGTIPALINL
LKSSKIKLQCKTVGLLSNISTHKRAVRALVEAGGIPSLINLLVCDEPEVHSRCAVILYDI
AQCE-NKDVIAKYNGIPSLINLLNLNIENVLVNVMNCIRVLCIGNENNQRAVREHKGLPY
LIRFLSSDSDVLKAVSSAAIAEVGRDNKEIQDAIAMEGAIPPLVALFKGKQISVQMKGAM
AVESLASHNPLIQKAFLEKSLTKYLLKLLKAFQIDVKEQGAVALWALAGQTLKQQKYMAE
QIGYSFIINMLLSPSAKMQYV---GGEAVIALSKDSRMHQNQICEGNGIAPLVRLLRIST
IAEGTLLSVIRAVGSVCIGVAHTS----NPVSQQFVVDENAFPVLIQLLRNHPSPNIKVE
V----AFSLACIVLGNDVLQKDLHENEGFEYADVLYLLHSTEKDICLRAGYALTLFAFNN
RFQQYLILESGIMTISIFEPFLESIVETEKAMAAFQIVVLAKVIRDVDHITLSAR--GVT
ILVDCLYSVQTSTIVLTGNLIASL----AHSRAGIPEAFTTLGTIQRLCYHLYSGTEEVR
AACSSALGYLTYNANAFRILFKECRNKPNQFIRIKNNISRDASINPAFLKEFQMQQTLVG
LPSLSLEK---NGGPSIIPIFKKGK----DHRRKLKPKIQPRDSLTLLPPVTNFM----G
LFKATKKTKDSHNI-FSFSSTITSDITN---------------VSRPRIVCLNQLGKHVQ
KANPEPAEG-------------------

MLRLPKKGAPRFDQNQDEETYLENLAVQRNASAFFEKYDRSEVQELLTTALVSWLSAKED
VRSQLDMPCGIMSQMNNVGFSTAILLTPVDPTALLDYREVHQIIRELAVGIYCLNQIPSI
SLEANYDQSSSCQLPPAYFDTRIGQILINIDYMLKALWHGIYMPKEKRARFSELWRTIMD
INPDGKPQTNRDIFAEFSSAGLIDITKDPDFDGIYNEDMNEDPTYNPNSPEEKAVFMKYA
EYILLKMTFSTTQVQQCENVFIFETAYWLTNAIKCNQDNLDICTYQRLHQRLYLQKKIIQ
KHLEKKKEIRKGIGYLKLICFLTPFLLSLKKKMKVPYLSGLLQPFS-DDKVKTERELPPF
IYGRDFKCQNFHYKEDQYFHIHGGIEFDISTPSIENASEDFKNNLEKIRDCAVNTF----
AEDSGYKEHYSIPVVKFNGKSYYVISFELEIFYQQLYKTQWWGAINEIVNNLRLKRLPLT
DAQLHEQFKKKFGFKKAMKCKSIPFGMKSAVERGLYAVFHTFSRKTSSSTINISDEAGYA
VFHHAALHNRVPIICQLCNANFNVNQRRFIILSQA-ESSKVDMKKERNGPTPLHLAAQAC
SLETTICLLCFKADYTLSEKRGWMPIHFAAFYDNICIIIVLCRKDPSLLE----------
AEATAENQCTPLLLAATSGALDSIQYLLSLGANWRKTDIKGNNIIHLSVLTFHTEVLKHI
IELNIPELPVWKTLVEMLQCESY-KRRMMAVMSLEVICLAH

PF00514 // ENSGT00680000100065_0_Domain_5 (762, 800)

DEYWKCILDAGTIPALINL
LKGSKIKLQCKTVGLLSNISTHPSIVHALVEAGAIPALINLLVSEEPELHSRCAVILYDI
AQLE-NKDVVAKHNGIPALINLLNLDIESVLVNVMNCVRVLCMGNKNNQRAVRDHKGIPY
LISFLSSDSDVLTAVSSVTIAEVARDNKEVQDAMALEGAIPPLVALFKGKQLSVQVKGAM
AVEALASYNPAIQRAFLEKSLSKYLLKLLKAFQIDVKEQGAVALWALAGQTLKQQKYMAE
QIGYNFIINMLLSPSAKMQYV---GGEAVIALSKDSKIHQNQICEGNGIAPLVRLLRISK
IADGTLLSVIKAVGSICIGVAHTS----NPISQQFVVDENAFPVLIQLLRSHPSPNIKVE
V----AFSLACIVLRNDLLQKELQENEGFDYADVLYLLHSEDKDICLRAGYALTLFAFNN
RFQQYLILENGKMSISIFEPFLESTIETEKAMAAFQIIVLAKVIIDVDHITLTAR--GVT
ILVDSLYSADSTTIVLTGNLIATL----AHSRAGIPEAFTTLGTIQQLCYHLYSGQEEVR
MACSSALGYLTYNANAFRLLLKECRNKPNQFLRITNNISRDASINPAFLKEFKMQQ-KVG
LPSLSLEK---NGGPSIIPVFKKGK----EHRRKLKPKIQPRDSLTFIPPVTNFM----G
LFKTTKKTTVSHNI-FSFSSAISSDIIT---------------VSRPRIVLLNQLGKHVQ
KANPEP----------------------

MLRLPKKGIPRFDQIPDEETYLENLSVQRNASAFFDKYERSEVQELLTTALVSWLSTKED
GRSQQDIPAGIMSQMNNVGFSTAILLMPVDPAALLDYREVHQILRELAVGIYCLNQIPSI
SLEANYDQSSSCHLPPAYFDTRIGQILIKTDYMLKALWHGIFMPKEKRTRFSELWRTIMD
VDPDGKPQTNKDIFAEFSSAGLIDVTEDPVFNGIYDDDMNEDPTYDPNSPEEISVFMKYA
ENIMLKLSFSTIHIQQYENVFIFETAYWLTNAITYTQDYLDICTYQRLQQRLYLQKKIIQ
KHLEKKNDIRRGIGYLKLICFLIPFLLSLKKKMKVPYLNNLLPPFS-DDKVKTERELPPF
IYGRDFKCQNFHYKDNQYFHVHGGIEFDISTSPIENALEDFKNNLEKIQECAANTF----
LEDSGYKEYYSIPVMEFYGKSYYVIHFELEIFYQQLYKTQWWSAINEIVNTLRVKRLPLT
DAQLHEQFKKKFGFKKAMKCKSIPFGMKSAVERGLSAVFHTFSRKTSSSTINVADEAGYT
IFHHAALHNRVSIICQLWNANFNVNQRRFIMFS--------------QGPTPLHLAAQAC
SLETTICLLSFKADYTLSEKRGWMPIHFAAFYDNICIIIALYRKDPSLLE----------
AEATAENQCTPLLLAATSGALDSIQYLFSLGADWRKTDTKGNNIIHLSVLTFHTEVLKYI
I

PF05804 // ENSGT00680000100065_0_Domain_6 (722, 904)

ELNIPELPVWKTLVEMLQCESY-RRKMMAVMSLEVICLAKDQYWKFILDAGTIPALINL
LKIPKIKLQCKTVGLLSNISTHTSAVHALVEAGGIPALIDLLTSEEPELHSRCAVILYDI
ALHD-NKDIIAKYNGIPNLINLLNLDIEGVLVNVMNCIRVLCMGNERNQRAVRDHKGLQP
LIKFLSSDSDVLIAVSSATLAEVGRDNTEIQNAIAAAGGIPPLVALFKGKQLNVQMKGAM
AVESLASCNSGIQKAFLEKSLTKYLLKLLKAFQIDVKEQGAIALWALAGQTLKQQKYMAE
QIGYNFIINMLLSPSAKMQYV---GGEAVIALSKDSRMHQNQICEGNGIAPLVRLLRISK
IAEGTLLSVIRAIGSICIGVAHTS----NPVSQQYIVEENAFPLLIQLLRSHPSPHIRVE
V----AFSLACIVLRNDLLQKDLRENEGFEYADVLYLLHSTDKDICLRAGYALTLFAFNN
RFQQYLILEKGIISISIFERFLESTIQTEKAMAAFQIIVLAKVITDVDHITLFAR--GVT
ILVDSLYSVHPPTIVMAGNLIASL----ALTRGGIAEAFTSVGTIQRLCYHLYSGVEEVR
TACSCALGYLTYNANAFRLLLKECRNKPNQFLRLTTNISRDASINPAFLKEFHMQQ-TVG
LPSLSLEK---NGGPSIIPVFKKGI----EHRRKSKPKIQPRDSYTLIPPVTNFT----G
LFKATQKTKVSQNV-FSFSSAIPSDIIN---------------VSRPRIVFLNQLGKHIQ
RSNSEPNEG-------------------

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-----------------------------------------FQDIRLRAGYAVSLFAFNN
CLQQFLILESGTITISIFEPFLTSDIETEKAMAAFQHLERCLAHSSGGNEELSAHYVPST
VLSVGVDATRSPTVTDTGNLIASL----AHTRAGIPEAFTA

PF00514 // ENSGT00680000100065_0_Domain_11 (1302, 1331)

LGAVHHLCSHLYSKKEEVR
IACSCALGYLTFNATARRQLLQECHNKPKQFTRLTKNLSRDAIINPEFIQDFNRQK-RVG
LPALSLEI---NGGPP--------------------------------------------
------------------------------------------------------------
----------------------------

MLRLPKKGLQRFDQVQDEETYLQNLAVQRNASAFFEKYDRSEVQELLTIALVSWLSGKED
VHLQIESPSGIMSHLNNVGFNTTILLMPVDPTALLDYREVHQIIRELAVGIYCLNQIPGI
SLEANYDQSSSCQLPPAYFDTRIGQILINVDYMLKALWHGIYMPKEKRTRFSELWRTILD
IDPEGKAQTNKDIFAEFSSAGLIDITKDPDFDGIYDEDMNEDPTYNPNSPEETAVFMKYA
ENILLKLTFSTTQIQQYENVFVFDTAYWLTNAIKCTQDCLDICTYQRLQQRLYLQQKVIQ
KHFEKKKEIRRGIGYLKLICFLTPFLLSLKKKMKVPYLSSLLQPFSGDDKVKTERELPPF
IYGPDFKCQSFQYAKHQYFHVHGGIEFDITTPMIENALEVFQDNLEKIQECAASTF----
AEDSGYKEYYSIPVMELNGKSYYVISFELETFYQQLYKTQWWGAINEIVNNLRPKRLPLT
DTQLHEQFKKKFGFKKAMKCKSIPFGMKSAVEKGLSAVFHTFSRKTSSSTINVSDE

PF00023 // ENSGT00680000100065_0_Domain_0 (537, 569)

AGYA
IFHHAALHNRVPIICQLCKANFNVNQRR

ENSGT00680000100065_0_Linker_0_1 (569, 588)

FIMFSQGTESSKTDGKKER

PF00023 // ENSGT00680000100065_0_Domain_1 (588, 620)

NGPTPLHLAAQAC
SLESTTCLLCFKADYTLPE

ENSGT00680000100065_0_Linker_1_2 (620, 621)

K

PF00023 // ENSGT00680000100065_0_Domain_2 (621, 663)

RGWMPIHFAAFYDNICIIMILCRKDPSLLE----------
AE

ENSGT00680000100065_0_Linker_2_3 (663, 667)

ATAE

PF00023 // ENSGT00680000100065_0_Domain_3 (667, 699)

NQCTPLLLAATSGALDTIKYLFSLGANWRKTD

ENSGT00680000100065_0_Linker_3_4 (699, 700)

T

PF00023 // ENSGT00680000100065_0_Domain_4 (700, 722)

KGNNIIHLSVLTFHTEVLKHI
I

ENSGT00680000100065_0_Linker_4_5 (722, 761)

ELHLPELPVWKTLVEMLQGESY-KRKMMAVMSLEVICLA

PF00514 // ENSGT00680000100065_0_Domain_5 (761, 801)

KEEYWRCILDAGTIPALINL
LKGSKMKLLCKTAGLLSNIS

ENSGT00680000100065_0_Linker_5_6 (801, 802)

T

PF00514 // ENSGT00680000100065_0_Domain_6 (802, 842)

HANVVHAIVEAGGIPVLISLLVSEEPELHSHCAVILYDI
AQLE-NKEVIAKHNGIPTLINLLKLDIENVLVNVMNCIRVLCMG

PF00514 // ENSGT00680000100065_0_Domain_8 (885, 925)

NESNQRAVRDHKGMQY
LINFLSSSSDLLKAVASATIAEVARDNKEVQNALAAEGVIPPLVALFKGKQLSVQVKGAM
AVEALASYNPSIQRAFLENSLSKYLLKLLKAFEISVKEQGAVALWALAGQTLKQQKYMAE
QIGYNFIINMLLSPSAKMQYV---GGEAVIALSKDSRLHQNQICEGNGIAPLVRLLRISK
LAEGTLLSVIRAVGSMCIGVAHTS----NPISQQFMVEENAFPVLIQLLRSHPSLSIKVE
V----AFSLACIVLRNKLLQKELQENEGFKYADVLFLLHAQDKDIRLRAGYALTLFAFND
VFQQYLILENGIMTLSIFEPFLESTIETEKAMAAFQIIILAKVIIDVDHITLSSR--GVT
ILIDSLYSLQSTTIVLTGNLIASL----AHS

PF00514 // ENSGT00680000100065_0_Domain_11 (1292, 1332)

RAGIPAAFASLGTVQRLCYHLYSGKEEVR
TACSCALGYLTYNAIAFRILLSECRNKPNQFLRIINSISRDASINPAFLKEFRMQQ-KVG
LPSLSLEK---NGGPCINLLSRKGR----EHRRKLRPKIQPRDSLTLLPPVTNFM----G
LFKTSKKSAVSHNI-FSFASATSSDVIQ---------------VSRPRIVLLSELGKHVQ
KDNVEP----------------------

MLRLPKKGLPRFDQIQDEETYLENLTVQRNASAFFEKYDRSEIQELLTTALVSWLSAKDD
VRSQLDLPCGIMTQMNNVGFSTAILLTPVDPTALLDYREVHQIIRELAVGIYCLNQIPSI
SLEANYDQSSSCQLPPAYYDTRIGQILINIDYMLKALWHGIYMPKEKRARFSELWRTIMD
IDPDGKPQTHKDIFAEFSAAGLIDITKDPDFNGIYDEDVNEDPTYNPNSPEEKAVFMKYA
ENIMLKLTFSTTQVQQYENVFIFETAYWLTNAIKYKQDYLDICTYQRLQQRLYLQKKVIQ
KYFEKKKEIRRGIGYLKLICFLTPFLLSLKKKMKVPYLSSLLPPFSGDDKVKTERELPPF
IYGRDFKCQHFHYKEDQYFHVHGGIEFDISTPSIESALEDFKNNLETIRDCAANAF----
VEDSGYKEYYSIPVMELNGKSYYVICFELETYYHQLYKTKWWGAINEVVSNLKPKRLPLT
DAQLHEQFKKKFGFKKAMKCKSIPFGMKSAVERGLSAVFHTFSRKTSSSTINVSDE

PF00023 // ENSGT00680000100065_0_Domain_0 (537, 569)

AGYA
IFHHAALHNRVAIICQLCNANFNVNQRR

ENSGT00680000100065_0_Linker_0_1 (569, 588)

FIMFSQA-DSSKMDVKKER

PF00023 // ENSGT00680000100065_0_Domain_1 (588, 620)

NGPTPLHLAAQAC
SLETTICLLCFKADYMLSE

ENSGT00680000100065_0_Linker_1_2 (620, 621)

K

PF00023 // ENSGT00680000100065_0_Domain_2 (621, 663)

RGWMPIHFAAFYDNIGIIIALYRKDPSLLE----------
AE

ENSGT00680000100065_0_Linker_2_3 (663, 667)

TTAE

PF00023 // ENSGT00680000100065_0_Domain_3 (667, 699)

NQCTPLLLAATSGALDTIQYLFSLGANWRKTD

ENSGT00680000100065_0_Linker_3_4 (699, 700)

I

PF00023 // ENSGT00680000100065_0_Domain_4 (700, 722)

KGNNIIHLSVLTFHTEVLKHI
I

ENSGT00680000100065_0_Linker_4_5 (722, 761)

ELNIPELPVWKTLVEMLQCESY-KRRMMAVMSLEVICLA

PF00514 // ENSGT00680000100065_0_Domain_5 (761, 801)

NDGYWKFILDAGTIPALINL
LKGSKIKLQCKTVGLLSNIS

ENSGT00680000100065_0_Linker_5_6 (801, 802)

T

PF00514 // ENSGT00680000100065_0_Domain_6 (802, 842)

HASIVHAIVEAGGIPALINLLASDEPELHSRCAVILYDI
AQLE-NKDVIAKYNGIPALINLLKLDIENVLINVMNCIRVLCMG

PF00514 // ENSGT00680000100065_0_Domain_8 (885, 925)

NEQNQRTVRDHNGIQY
LITFLSSDSDVLKAVSSATIAEVA

ENSGT00680000100065_0_Linker_8_9 (925, 927)

RD

PF00514 // ENSGT00680000100065_0_Domain_9 (927, 967)

NRDIQVAVAMEGAIPPLVALFKGKQLSVQVKGAM
AVESLA

ENSGT00680000100065_0_Linker_9_10 (967, 1109)

SHNPSIQRAFLEKSLSKYLLKLLKAFQIDVKEQGAVALWALAGQTLKQQKYMAE
QIGYNFIINMLLSPSTKMQYV---GGEAVIALSKDSRMHQNQICEGNGIAPLVRLLRMSN
VAEGTLLSVIRAVGSICIGVAHTS----

PF00514 // ENSGT00680000100065_0_Domain_10 (1109, 1154)

NPISQQFVVEENAFPVLIQLLRNHPSPNIKVE
V----AFSLACIVLRNDLLQNELQETEGFKYADVLYLLHSPDKDICLRAGYALTLFAFNN
RLQQYLILESGIMTISIFEPFLESAVETEKAMAAFQIIILAKVIIDVDHITLSAR--GVT
ILVDSLYSVHATTIALTGNLIASL----AHSRAGIPEAFTTLGTIQQLCYHLYSGKDEVR
TACSCALGYLTYNANAFRILLKECRNKPNQFLRITNNINRDASINPAFLKEFQMQQ-RVG
LPSLSLEK---NGGPSITPVFKKGK----EHRRKLKPKIQPRDSLTLIPPVTNFM----G
LFKTTKKTPVSHSI-FSFSPAISSDIIK---------------VSRPRIVFLSQLGKHVQ
KANLEP----------------------

MSRIVKKGIVKIDQEQDEETFRENLAVQRNASAFFEKYDRTEVQELLTTVLVSWLAAKDD
ARSQLDTPCGLMSQMNNAGFSTAILLTPVDPTALLDYREVHQILRELAIGIYCLNQIPSI
SLEANFDQSSSCQLPPAYYDTRVGQILIQIDYMLKALWHGIYMPREKRARFSELWRTIMD
IDLDGKPQTNKDVFSEFSSAGLVDITSDPDFDGIYDEDMNEDPTYEPNSPEEKAVFMKYA
ESMMMKLTFSTTQIQHHENIFIFETAYWLTNAIKYNQDYLDICTYQRLQKRLYLQKKVIQ
KHFEKKKEIRRGMGYLKLICFLIPFLLSLKKKMKVPYLNSLLPPFS-DDKVKTERELPPF
IYGRDFKCQNFDYKQHQYFHVHGGIEFDISTHAVESALDEFKKNVDKIWECASSAF----
AEDAGYREVYPIPVMEFNGKSYYVIHFELEIFYQQLYKTQWWVAINETVNNLKVKRLPLT
EDQLHEQFKKKFGLKKAMKCKSIPFGVKSAVERGLSAVFYTFSRKTSSSTINVSDDAGYA
IFHHAALHNRVSVISQLWSANFNVNQRRFIMFSQA-DSSKVDMKKERNGPTPLHLASQAC
SLEATICLLCFKADYTLTEKRGWMPIHLAAFYDNICILIALCRKDPSLLE----------
AEATAENQCTPLLLAATSGALDTIQYLFSLGANWRKTDAKGNNIIHLSVLAFHTEVLKYI
IELNIPELPVWETLVEMLQCESS-KRRMMAVMSLEVICLAN

PF00514 // ENSGT00680000100065_0_Domain_5 (762, 800)

DRYWQCILDAGTIPALVNL
LKSPQIKLQYKTVGLLSNI

ENSGT00680000100065_0_Linker_5_6 (800, 808)

STHISIVH

PF00514 // ENSGT00680000100065_0_Domain_6 (808, 837)

AIVEAGGIPALINLLTSDEPELHSRCAVILYDI
AKCE-NKNVIAKYNGIPALINLLTLNKEGVLVNVMNCIRVLCMGNESNQEAMRDNNGIQY
LIQFLSSDSDVLKALSSATIAEVARDNKEVQDAIAKEGAIPPLVALFKGKQLSVQVKGAM
AVESLASCNPLIQKEFLERELTKDLLKLLQAFQIDVKEQGAIALWALAGQTLKQQKYMAE
QIGYNLIISMLLSPSAKMQYV---GGEAVIALSKDSRMHQNQICEGKGIAPLVRLLRMNK
IPEGTLLSVIRAVGSICTGVAHTS----NPMSQQFVVEENALPVLIQLLRNHPSINIRVE
V----AFSLACIVLGNNSLKKELQKDEGFEYSDVLYLLHSKDKEVCLKAGYALTLFAFND
RFQQHLILETGLITVSLFEPFLQSRVETERAMAAFQIIVLAKAIIDVDHVTLYGR--GIQ
ILADSLNSVHAPTIALTGNLIASL----AHSKAGIPEAFVSLGTVQRLCYHLYARSEEVR
TACSCALGCLTYNAHAFRILLTECRNKPNQFLRITNNISKDVKMNPAFLKEFQLQQ-RMG
LPSLSLER---NGGPPVIPVFKKGK----EHRQKARPKIQPRDSLTLLPPVTNVK----E
LFRTTHKANISHNT-FSFPSGVSADIIN---------------VSRPRIAFLNKLGKDEQ
KANPDPPAFLNKLGKDEQNANPDPAESQ

MLRLPKKGLPRFEQVQDEETYLENLAIQRNASAFFEKYDRSEIQELLTTALVSWLSTKED
VRSQGDLPCGIMSQMNNVGFSTAILLTPVDPTALLDYREVHQMIRELAIGIYCLNQIPSI
SLEANYDQSSSCQLPPAYYDTRIGQILINIDYMLKALWHGIYMPKEKRARFSELWRTIMD
IDADGKPQTNKDIFSEFSSAGLTDITKDPDFNEIYDEDVNEDPTYDPNSPEETAVFMKYA
ENIMLKLTFSTTQVQQYENVFIFETDYWLTNAIKYNQDYLDICTYQRLQQRLYLQKKIIQ
KHFEKKKDIRRGIGYLKLICFLIPFLLSLKKKMKVPYLGSLLQPFS-DDKVKTERELPPF
IYGRDFKCQNFHYKENQYFHVHGGIEFDISTPSIENALEDFQKNLEKIRDCAANTF----
IEDSGYKEYYSIPVMEFHGKSYYVMYFELETFYQQLYKTQWWGAINEIMNNLRPKRLPLT
DAQLHEQFKKKFGFKRAMKCKSIPFGMKSAVERGLSAVFHTFSRKTSSSTINVSDEAGYT
IFHHAALHNRVSIICQLCNANFKVNQRRFVTFG--------------QGPTP

PF12796 // ENSGT00680000100065_0_Domain_2 (593, 697)

LHLAAQAC
SLETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIVIALCRKDPSLLE----------
AEATAENQCTPLLLAATSGALDTIQYLFSIGANWRKTDTKGNNIIHLSVLTFHTEVLKYI
IKLNIPELPVWKTLVEMLQSESY-KRRMMAVMSLEVTCLAN

PF00514 // ENSGT00680000100065_0_Domain_5 (762, 800)

DQYWRCILDAGTIPALINL
LKSSKIKLQCKTVGLLSNISTHKRAVRALVEAGGIPSLINLLVCDEPEVHSRCAVILYDI
AQCE-NKDVIAKYNGIPSLINLLNLNIENVLVNVMNCIRVLCIGNENNQRAVREHKGLPY
LIRFLSSDSDVLKAVSSAAIAEVGRDNKEIQDAIAMEGAIPPLVALFKGKQISVQMKGAM
AVESLASHNPLIQKAFLEKSLTKYLLKLLKAFQIDVKEQGAVALWALAGQTLKQQKYMAE
QIGYSFIINMLLSPSAKMQYV---GGEAVIALSKDSRMHQNQICEGNGIAPLVRLLRIST
IAEGTLLSVIRAVGSVCIGVAHTS----NPVSQQFVVDENAFPVLIQLLRNHPSPNIKVE
V----AFSLACIVLGNDVLQKDLHENEGFEYADVLYLLHSTEKDICLRAGYALTLFAFNN
RFQQYLILESGIMTISIFEPFLESTVETEKAMAAFQIVVLAKVIRDVDHITLSAR--GVT
ILVDCLYSVQTSTIVLTDIPLFGFLLSSCAHFSWYPEAFTTLGTIQRLCYHLYSGTEE--
-ACSSALGYLTYNANAFRILFKECRNKPNQFIRIKNNISRDASINPAFLKEFQMQQTLVG
LPSLSLEK---NGGPSIIPIFKKGK----DHRRKLKPKIQPRDSLTLLPPVTNFM----G
LFKATKKTKDSHNI-FSFSSTITSDITN---------------VSRPRIVCLNQLGKHVQ
KANPEPAEG-------------------

MLRLPKKGLPRFDQNQDEETYLENLAVQRNASAFFEKYDRSEVQELLTTTLVSWLSAKDD
VRSQLDLPCGIMSQMNNVGFSTAILLTPTDPTALLDYREVHQIIRELAVGIYCLNQIPSI
SLEANYDQSSSCQLPPAYYDTRVGQILIAVDYMLKALWHGLYMPKEKRARFSELWRTVVD
IDPDGKPQTHKDIFAEFSAAGLVDITKDPDFNGIYDEDMNEDPTYDPNSPEEKAVFMKYA
ENIMLKLTFSTTQVQQYENVFIFETAYWLTNAIKYNQDYLDICTYQRLQQRLYLQKKVIQ
KHFEKKKEIRKGIGYLKLICFLTPFLLSLKKKMKVPYLSSLLQPFSGDDKVKTERELPPF
IYGRDFKCQHFHYKEDQYFHVHGGIEFDISTPSIENALEDFKNNLEKIRDCAANTF----
AEDSGYKEYYSIPVMELNGKSYYVICFELETFYHQLYKTKWWGAINEIVNVLKPKRLPLT
DAQLHEQFKKKFGFKKAMKCKSIPFGMKSAVERGLSAVFHTFSRKTSSSTINVSDEAGYT
IFHHAALHNRVAVICQLCNANFNVNQRRYIMFNQE--SSKMDTKRERNGPTPLHLVAQAC
ALEATVCLL-FRADLTLAACPGLACHPLRRLYNNICVSAALCKLDPAL-E----------
AEA

PF12796 // ENSGT00680000100065_0_Domain_3 (664, 721)

ATWNQCTPLLLAATSGALDTIRYLLSLGANWRKTDTKGNNIIHLSVLSFHTEVLKHI

ENSGT00680000100065_0_Linker_3_5 (721, 764)

IALSIPELPVWATLVEMLQCESY-KRRMMAVMSLEVICLANDG

PF00514 // ENSGT00680000100065_0_Domain_5 (764, 800)

YWKCILDAGTIPALINL
LKGSKIKLQCKTVGLLSNLSTRASVVRAVVAAGGVPALLGLLASDEPELHSRCAVILYDV
AQLE-NKDVIARYNGIPTLISLLKLNIENVLINVMNCIRVLCMGNEQNQRAVRDHKGIQY
LITFLSSDSDVLKAVSSATIAEVARDNRSVQDAMAAEGAIPPLVALFKGKQLSVQVKGAM
AVESLASYNPSIQRAFLEESLSKYLLKLLKAFQIDVKEQGAVALWALAGQTLKQQKYMAE
QIGYNFIISMLLSPSAKMQYV---GGEAVIALSKDSRMHQNQICEGNGIAPLIRLLRISK
IAEGTLLSVIRAVGSICIGVAHTS----NPISQQFVVQENAFPVLLQLLRNHPSPNIRVE
V----AFSLACIVLRNDLLQNELQENEGFKYADVLYLLHSQDKDICLRAGYALTLFAFNN
RLQQYLILESGVMTISIFEPFLESTIETEKAMAAFQIIILAKVIIDVDHITLSAR--GVT
ILVASLYSVHSTTIVLTGNLIASL----AHSRAGIPEAFTTLGTIQRLCYHLYSGKEEVR
AACSCALGYLTYNAAAFRLLLKECRRRPGQFLRLTRNISRDASVNPAFLREFQWQQ-QVG
LPSLSLER---NGGPSVTPVFKKGK----EHQRKLIPKIQPRDSLTLIPPITNFT----G
LFKTTKKTTVSHNI-FSFSSAIPSDITE---------------VSRPRIVFLNQLGKHVQ
KANSEP----------------------

MLRLPKKVLTRLDQIQDDETYLENLAVQRNASAFFEKYDRSEVQELLTTALVSWLSTKED
VRSQLDIPCGIMTQMNNFAFSTAILLTPVDSDALLDYREVHQIIRELAVGIYCLNQIPSI
SLEANYDQSSSCHLPPAYYDTRIGQILIDIDYMLKALWHGIYMPKEKRARFSELWRTIMD
IDPDGKPQTSKDIFAEFNAAGLVDITKDPDFDGIYDEDMNEDPTYNPNSPEEKAVFMKYA
ENIMLKLTFSTIQVQQYENVFIFETAYWLTNAIKYNQDYLDICTYQRLQQRLYLQKKIIQ
KHFEKKKEIRGGLGYLKLICFLIPFLLSLKKKMKVPYLSSLLQPFS-DDKVKTERELPPF
IYGQDFKCQNFYYKENQYFHMHGGIEFDISTPSIENALEDFKNNLEKIRDCAANTF----
AEDSGYKEYYSIPVMEFYGRSYYVICFELEAFYQQLYKTQWWGAINEIVNSLRVKRLPLT
DAQLHDQFKKKFGFKKAMKCKSIPYGLKSAVERGLSAIFHTFSRKTSSSTINVSDEAGFA
IFHHAALYNRVPIICQLCNANFNVNQRRFIMFSQA-DSSKVDMKKERTGPTPLHLAAQAC
SLETTICLLCFKADYTLSEKRGWMPIHFAAFYDNICIVIALCRKEPSLLE----------
AETTAENQCTPLLLAATSGALDTIQYLFSLGANWRKMDAKGNNIIHLSVLTFHTEVLKHI
IELDIPELPVWKTLVEMLQCESY-KRRMMAVMSLEVICLANERYW

PF00514 // ENSGT00680000100065_0_Domain_5 (766, 800)

KCILDAGTIPALINL
LKCPKIKLQCKTVGLLSNISTHNSVVHALVESGGIPAVINLLASDEPELHSRCAVILYDI
AQCE-NKDVVAKYNGIPALINLLTLNIENVLVNVMNCIRVLCIKNEINQRAVRDHNGIQH
LIRFLSSDSDVLKAVSSATIAEVGRDNKEIQNAIIMEGAINPLVALFKGTQLSVQVKGAE
AVESLASFNPLIQKAFLERKLTKYLLKLLKAFQIDVKEQGAMTLWALAGQSLKQQKHMAE
QIGYNFIISMLLSSSAKMQYV---GGEAVIALSKDSRLHQNQICEGNGIAPLVRLLKISR
LTEGTLLSVIRAVGSMCIGVAHTS----NPVSQQFIVEEDALPVLIQLLRNHPSPNIKVE
V----AFSLACIVLRNEVLQNELLDNEGFKYSDVLHLLHSTDKDICLRAGYALSLFAFNN
RFQQYLILESGIMTISIFEPFLESAVETERAMAAFQIIVLSKVIVDVDHITLTAR--GVT
ILVDSLYSVQPATLVLTGNLIASL----AHSRAGIPEAFTSLGTIQRLCYHLHSVREEVR
TACSCALGYLTYNANAFRILLKECRNKPNQFLRLTNNINRDASINPAFLKEFQMQQ-TVG
LPSLSLEK---NGGPSIIPVFKKGK----EHRRKAKPKIQPRDSLTLIPPVTNFM----G
LFKTTENTDVPVNL-FSFSSALSSDIIN---------------ISRPRIVCLNQLGKHVQ
KANSEPSEG-------------------

MLRSVKKALPRSEQA-DETNYLANLAVQRNASAFFDKFDRSELQELLTTASCSWLASKDD
LRQPLELPNGLMGQLKNISFPSAILLAPVVPDVPLDCKEIHQIVRELAVGLYCLNQVPSI
SLDANYDHSTSCQLPPAYFDTRIGQMLISVDYMLKALWHGVYMPKEKRARFSELWRSSMD
IDMDGNPQTEKNIFSEFCSAGLVDISNEPGFEGIYDENMNEDPTYDPNSAQEKNLFMQYA
DSILLKLTFGTIQVQQHENVCKFDAVYELSNVIRLTEDYLDTDTYQRLQQRLTLQQKLVK
KHLEKKAEIRKNIEYLKILSFLIPFLLGLKKKMKVPNLNQLLQPYS-DDKVKTERELPPF
VLGPDFKCQHFHYVKNEYFHVHGGIEFDIGTPSVEDVSEEIKAAFNDIQNCASNHIAQLL
DPDIPYREHYPIPTMEFDGKKYYVIAIELETFYQQLYKTPWWVAINEIISTLKPKRLPLT
DIQSLEQFKKRFGYKKAIKCKSLPYGMKSAAERGLAAIFHTFCRKTSTSSLSVVDEYGYA
LLHHASIHNRVPIIYQMIKSHLNINQRRNVHYNPGRRSQKGETKGDRAGPTALHLASQCG
SIEALNCLLAFKADYKLTDDRGWMAIHFAAFYDNISCIKVLCRKDPDLLE----------
TETTAKYHSTPLLLAATSGALDTLQYLFSLGANWKKTDSEGNNIIHLAVLYFHTEILKHL
IVLDNPDLPVWNTLVEMLQCEDP-SRTEMAVRSLEVLCLAEDFYWKCILDSGAIPSLINL
LKGHHIKQLCITSGVLSNISPHIAISKALVEAGGISVLIELLGSGEPELQSRCAVILYDI
AQFNDNQNVITELGGIPPLVNLLKIKIQDLLVNVINCIRVLCIQ

PF00514 // ENSGT00680000100065_0_Domain_8 (885, 925)

NKHNQSAVKDHHGIPA
LVEFLTSESDVLQAISAAALAELARGNEMMQDAIANADAIGPLVELLRGRKVSVQVKGAM
AIEMLSENNSSIQKEFLERSVTKDLLKLFKAFHLTVKEQGATTLWALAGQTLKQQKLMAE
QIGYNFIIDMLLSPSDKMQYVE--GGEAVIALSKDSRLHQNQICEGNGIGPLVRLLRSTK
IAEGTLLSVIRALGTICIGVAHTN----NPVSQENIVEEQALPILVHLLKNHNSLQIKVE
V----AYSLACIVLRNSKLQTVLQEEEGFDYRDVLELLNAPDKDIRLRAGYALALFAYNN
PVQQFLMLETGAITLSTFDPFLFSEIETDKALAAFQIVVLARVIVDVDQVTLSAR--GIA
ILVGLLNSKKTATLVLTGKLLASL----AHTRAGIP

PF00514 // ENSGT00680000100065_0_Domain_11 (1297, 1331)

EAITELGTVQQLCYHLYSDKEEIR
IAAAGALGYLTFNGVAYRQLLVECRNKPKQFTRLMNNLSRDAKISQKFVKEFQRQR-EVG
LPSLSLMI---NGGPPTVPTYAKERSQSSSGRRQFKSKFRAKDSLLLMPISAHLM----G
KLRTTDKPRGQTTGLRSFAHA-TSDIT---------------EISRPRIFDVSKL-----
----------------------------

MLRQIKKLAPRNEQA-DEAAYLAQLAAQRNATAFFEKYERSELQELLTMSFCSWLASKDD
LRRPLDLPSGLVEEMKSFTVQSVILLAPVEPGLALDCKEIHQMIRELSVGVFCLNQIPSI
SLDANYDQSTSCSLAPAYFDTRIGQMLIAVDYMLKALWHGAYMSKEKRVRFSELWRSSMD
IDADGIPQTERTACSEFCQAGLVDISKEPDFRGIYDENMNEDPTYDPNSAEEKKIFMQFV
EYMLLKLTFGTTEIQQHENLFLFDSAYTVTNAIRVTEDRLDTILYQRLQQRLILQQKLVR
KHLEKKPEIRNYIAYLKLLSFLIPFIVSLKRKNKVPNLSRLLQPYS-DDKVKTEREFPPI
LLGPDFKCQHFMYPQNRYFHLHGGIEFDIGTPSVGNVSEEIKDAYDEICECAANHLSQLL
DPDAPYREHYSIPIMDFGGKSYYVIGIELEPFYL-LFKSQWWGAINEVISMLKPKRLPLI
DTQAMELFKRRFGYKKAIKCKHMAYGMKAAAERGLAAVFLTFCRKTSISSLTTTDEHGYS
LIHHAAIYNWVAIICQVVKSSLAMNQRRSIPIS--------------QGPTALHLAAQCS
SLEALHFLLALKADYRIPDHRGWLPIHYAAFYDNVACITVLYRKNPDMIE----------
AETRAEFHSTPLLLAATSGALDTIRYLFSLGANWLKKDIEGNTIIHLAVMNFHTEVLKHL
NELHNPDLPV

PF05804 // ENSGT00680000100065_0_Domain_6 (731, 913)

WKILVDMLDCKAVRKKREMAVRCLEVLCLAKDNYWKSILDAGTIPSLISL
LKSGDIVLECITVGVLSNISTHNSIARALVDAGGISVLIKLLASDHPDLLSRCAVLLYDI
AQLDNNQAIIAEQGAIPALVNLLQYDLHDLLVNVINCIRVLCLNNHENQLKVKEANGIEP
LVQFLDSESDVLLAVASATIAEVARGNCEMQNAIVEAHVIGRLVELLRGRKISVQVKGAM
AIEALCANNSYIQMRFLAKSVTRFLLKLLKAFHLKVKEQGAATLWALAGQTLKQQKYMAE
QIGYNLIIDMLLSPSDRMQCV---GGEAVIALSKDSQLHQNQICEGNGIGPLVRLLRSGR
IADSTLISIIRALGTICVGFNSNPNHRIHPVQPTFCLHTGKAPFIYLFIYNIYNPPFFLT
LKGTQGGSHYTLIEGDLFVHSLLHIDKLFQLQGMTWLYHNNFQDICLRAGHAIAFFAYNN
PTQQLLILDTGPISLSMFEDFLLSDVEIERAMAAFQIVVLARIIVDKDQVSLSAR--GVS
ILVDLLCSEKAATLVLTGKLLASL----AHTRAGIPEAITSLGTVQRLCYHLYAKEEEVR
TAMSSALGYLTFNRTAYRHLLVQCRNKPKLFKRLIKNLSRDARINPDFVKEFKRQK-KIG
LPSLR-------------------------------------------------------
------------------------------------------------------------
----------------------------

------------------------------------------------------------
-----------MTQMNNVGFSTAILLTPVDSDALLDYREVHQIIRELAVGIYCLNQIPSI
SLEANYDQSSSCQLPPAYFDTRVGQILINIDYMLKALWHGIYMPQEKRARFSELWRTIMD
IDPDGKPQTSKDIFAEFSAAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XDKVKTERELPPF
IYGQDFKCQNFYYKENQYFHVHGGIEFDISTPSIENALEDFKNNLEKIRDCAAHTF----
GEESGYKEYYPIPVIEFYGRSYYVICFELEGFYQQLYKTQWWGAINEIVNSLRLKRLPLT
DAQLHDQFKKKFGFKKAMKCKSIPFGLKSAVERGLAAIFHTFSRKTSSSTINVSDE

PF00023 // ENSGT00680000100065_0_Domain_0 (537, 569)

AGFA
VFHHAALYNRVSIICQLCNANFNVNQRR

ENSGT00680000100065_0_Linker_0_1 (569, 588)

FIMYS--------------

PF00023 // ENSGT00680000100065_0_Domain_1 (588, 620)

QGPTPLHLAAQAC
SLETTICLLCFKADYMLSE

ENSGT00680000100065_0_Linker_1_2 (620, 621)

K

PF00023 // ENSGT00680000100065_0_Domain_2 (621, 664)

RGWLPIHFAAFYDNICIIIALCRKDPALLE----------
AEA

ENSGT00680000100065_0_Linker_2_3 (664, 667)

TAE

PF00023 // ENSGT00680000100065_0_Domain_3 (667, 699)

NQCTPLLLAATSGALDTIQYL-SLGANXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXMLQCESY-KRRMMAVMSLEVICLANDRYWKCILDAXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXX-XXXXXXXXNGIPALINLLTLNIENVLINVMNCIRVSCIK

PF00514 // ENSGT00680000100065_0_Domain_8 (885, 925)

NEINQRAVRDHNGIPH
LIRFLSSDSDVLKAVSSATIAEVGRDNKDIQNAIVAEGAINPLVALFKGTQLSVQVKGAE
AVESLASFNPHIQKAFLERKLTKYLLKLLKXXXXXXXXXGAMTLWALAGQSLKQQKHMAE
LIGYNLIISMLLSSSAKMQYV---GGEAVIALSKDSRMHQNQICEGNGIAPLVRLLKINR
LTEGTLLSVIRAVGSICIGVAHTN----

PF00514 // ENSGT00680000100065_0_Domain_10 (1109, 1154)

NPVSQQFVVEENALPVLIQLLRSHPSPNIKVE
V----AFSLACIVLRNEALQNELQEKEGFRYSDVLYLLHSTDKDICLRAGYALSLFAFNN
RFQQYLILESGTMTISIFEPFFESTVETERAMAAFQIIVLAKVIIDVDHITLTAR--GVT
ILVDSLYSLQPNTIVLTXXXXXXX----XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
TACSCALGYLTYNANAFRILLRECRNKPNQFLRLTNNINKDANINPAFLKEFQIQQ-TVG
LPSLSLEK---NGGPSIIPVFKKGKE----HRRKAKPKIQPRDSLTLIPPVTNLK----G
LFKTSENADVP-LSILSFSSALSSDIIN---------------ISRPRIVCLNKLGKNIQ
KANSEPSES-------------------

MLRLPKKGLPRFEQVQDEDTYLENLAIQRNASAFFEKYDRSEIQELLTTALVSWLSAKED
VRSQVDLPCGIMSQMNNVGFSTAILLTPVDPTALLDYREVHQMIRELAIGIYCLNQIPSI
SLEANYDQSSSCQLPPAYYDTRIGQILINIDYMLKALWHGIYMPKEKRARFSELWRAIMD
IDPDGKPQTNKDIFSEFSSAGLTDITKDPDFNEIYDEDVNEDPTYDPNSPEETAVFMKYA
ENIMLKLTFSTTQIQQYENVFIFETGYWLTNAIKYNQDYLDICTYQRLQQRLYLQKKIIQ
KHFEKKKDIRRGIGYLKLICFLIPFLLSLKKKMKVPYLSSLLQPFS-DDKVKTERELPPF
IYGRDFKCQNFHYKENQYFHVHGGIEFDISTPSIENALEDFQKNLEKIRDCAANTF----
IEDSGYKEYYSIPVMEFHGKSYYVIYFELETFYQQLYKTQWWGAINEIVNNLRLKRLPLT
DAQLHEQFKKKLGFKRAMKCKSIPFGMKSAVERGLSAVFHTFSRKTSSSTINVSDEAGYT
I

PF12796 // ENSGT00680000100065_0_Domain_1 (542, 642)

FHHAALHNRVSIICQLCNANFKVNQRRFVTFS--------------QGPTPLHLAAQAC
SLETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLE----------
AEATAENQCTPLLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYI
IKLNIPELPVWKTLVEMLQCESY-KRRMMAVMSLEVICLAN

PF00514 // ENSGT00680000100065_0_Domain_5 (762, 800)

DQYWRCILDAGTIPALINL
LKSSKIKLQCKTVGLLSNISTHKSAVHALVEAGGIPSLINLLVCDEPEVHSRCAVILYDI
AQCE-NKDVIAKYNGIPSLINLLNLNIENVLVNVMNCIRVLCIGNENNQRAVREHKGLPY
LIRFLSSDSDVLKAVSSAAIAEVGRDNKEIQDAIAMEGAIPPLVALFKGKQISVQMKGAM
AVESLASHNALIQKAFLEKSLTKYLLKLLKAFQIDVKEQGAVALWALAGQTLKQQKYMAE
QIGYSFIINMLLSPSAKMQYV---GGEAVIALSKDSRMHQNQICEGNGIAPLVRLLRIST
IAEGTLLSVIRAVGSICIGVAHTS----NPVSQQLVVDENAFPVLIQLLRNHPSPNIKVE
V----AFSLACIVLGNDVLQKDLHENEGFEYADVLYLLHSTEKDICLRAGYALTLFAFNN
RFQQYLILESGIMTISIFERFLESTVETEKAMAAFQIVVLAKVIRDMDHITLSAR--GVT
ILVDSLYSVQTSTIVLTGNLIASL----AHSRAGIPEAFTTLGTIQRLCYHLYSGIEEVR
AACSSALGYLTYNANAFRILLKECRNKPNQFIRIKNNISRDASINPAFLKEFQMQQTLVG
LPSLSLEK---NGGPSIIPIFKRGK----EHRRKLKPKIQPKDSLTLLPPVTNFM----G
LFKATKKTKDSHNI-FSFSSTITSDITN---------------VSRPRIVCLNQLGKHVQ
KANPEPAEG-------------------

MLRLPKKGIPRLDQVQDEETFLENLAIQRNASAFFEKYDRSEIQELLTTALVSWLSTKED
GRSQVDMPCGIMSQMNNVGFSTAILLTPVDPTALLDYREVHQIIRELAIGIYCLNQIPSI
SLEANYDQSSSCQLPPAYYDTRIGQILINIDYMLKALWHGIYMPKEKRARFSELWRTILD
IDPDGKPQTNKDIFAEFSSAGLTDITKDPDFNGIYDEDMNEDPTYDPSSPEETAVFMKYA
ENIMLKLTFSTTQVQQYENVFIFESDYWLTNAIKYNQDYLDICTYQRLQQRLYLQKKIIQ
KHFEKKKDIRRGIGYLKLICFLIPFLLSLKKKMKVPYLNSLLQPFS-DDKVKTERELPPF
IYGRNFKCQNFHYKENQYFHVHGGIEFDISTPSTENALEDFQKNLEKIRDCAANTF----
IEDSGYKEYYSIPVMEFYGKRYYVIYFELETFYQQIYKTQWWGAINEIVNNLRLKRLPLT
DAQLHEQFKKKFGFKKAMKCKSIPFGMKSAVERGLSAVFHTFSRKTSSSTINVADEAGYT
IFHHAALHNRVSIICQLCNANFRVNQRRFVMFS--------------QGPTPLHLAAQAC
SLETSVCLLCFKADYMLSEKRGWMPIHFAAFYDNICIIIALCRKDPSLLE----------
AEATAENQCTPLLLAATSGALDTIQYLFSVGANWRKTDIKGNNIIHLSVLTFHTEVLKYI
IKLNIPELPVWKTLVEMLQCESY-KRRMMAVMSLEVICLAN

PF00514 // ENSGT00680000100065_0_Domain_5 (762, 800)

DQYWRCILDAGTIPALINL
LKSSKIKLQCKTVGLLSNISTHKSAVHALVEAGGIPSLINLLVCDEPELNSRCAVILYDI
AQCE-NKDVIAKYNGIPSLINLLNLNIESVLVNVMNCIRVLCVGNENNQRAVREHKGLPY
LIRFLSSDSDVLKAVSSATIAEVGRDNKEIQDAIALEGAIPPLVALFKGKHISVQMKGAM
AVESLASHNPFIQKAFLEKSLTKYLLKLLKAFQMDVKEQGAIALWALAGQTLKQQKYMAE
QIGYSFIINMLLSPSAKMQYV---GGEAVIALSKDSRMHQNQICEGNGIAPLVRLLRISK
IAEGTLLSVIKAVGSVCIGVAHTS----NPVSQQVVVDENALPVLIQLLRNHPSPYIKVE
V----AFSLACIVLGNDVLQKDLHENEGFDYADVLYLLHSTEKDICLRAGYALTLFAFNN
RLQQYVILESGIMTICIFEPFLESTIETEKAMAAFQIVVLAKVIRDVDHITLSAR--GVT
ILVDSLYSVQTSTIVLTGNLIASL----AHSRAGIPEAFTTLGTVQRLCYHLYSGTEEVR
AACSCALGYLTYNANAFRILLKECRNKPNQFIRIKNNISRDASINPAFLKEFETQQTLVG
LPSLSLEK---NGGPSIIPVFKKGK----EHRRKLKPKIQPKDSLTLLPPVTNFV----G
LFKETKKTKDSHNI-FSFLSTTTSDITN---------------ISRPRIVCLNQLGKHVQ
KANPEPAEGQ------------------

MLRIVKKGIVRFDQGQDEETFLENLAVQRNASAFFEKYERSEVQELLTTALVSWLAAKDD
VRSQLDIPCGLMSQINNVGFSTAVLLTPVDPTTQLDYREVHQILRELAIGIYCLNQIPSI
SLEANFDQSSSCQLPPAYYDTRVGQILIHIDYMLKALWHGIYMPREKRARFSELWRTIMD
IDQDGKPQTTKNIYSEFSSAGLVDITNDPDFEGIYDEDMNEDPTYEPNSPEEKAMFMKYA
EGMMMKLTFSTTHIQQHENIFIFETAYWLTNAIKYNQDYLDICTYQRLQQRLSLQKKVIQ
KHFEKKKEIRRGIGYLKLICFLIPFLLSLKKKMKVPYLNSLLPPFS-DDKVKTERELPPF
MYGRNFKCQNFDYKEHQYFHVHGGIEFDISTSPVENALDDFKNNAKKIWACAANTF----
TEDSGYKEFYSVPVMEFYGKSYYVIYFELEIFYQQLYKTQWWGAINEIVNNLRLKRLPLT
EAQLHEQFKKKFGLKKAMKCKSIPFGLKSAVERGLSAVFHTFSRKTSSSTINVSDEAGYA
IFHHAALHNRVPIICQLCNANFNVNQRRFIMFTQ--ESSKMDMKKERNGPTPLHLAAQAC
SLEATICLLCFKADYTLTEKRGWMPIHFAAFYDNICIIIALCRKDPSLLE----------
AEATAENQCTPLLLAATSGALDTIQYLFSLGANWRKTDTKGNNIIHLSVLTFHTEVLKYI
IELHIPELPVWKTLVEMLQCESF-KRRMMAVMSLEVICLA

PF00514 // ENSGT00680000100065_0_Domain_5 (761, 800)

NDEYWQNILDAGTIPALVNL
LKCPKIKLQCKIVGLLSNISIHVSVVHALVEAGGIPALISLLASDEPELHSRCAVILYDI
AKCE-NKDVIAKYNGIPALINLLSLNKENVLVNVMNCIRVLCMGNEGNQKAMRDYNGIHY
LIQFLSSDSDVLKAVSSATIAEVGRDNKQVQDAIAMEGAIPPLVALFKGKQLSVQVKGAM
AVESLANRNPSIQKAFLERKLTKDLLKLLKAFQIDVKEQGAIALWALAGQTLKQQKYMAE
QIGYNFIINMLLSPSAKMQYV---GGEAVIALSKDSRKHQYQICEGNGIAPLIRLLRISK
IAEGTLLSVIRAVGSICIGVAHTS----NPMSQQCVVEENAFPVLIQLLRSHPSINIKVE
V----AFSLACIVLGNDSLQKELQENEGFEYSDVLYLLHSKDKEICLRAGTHLTLFAFNN
RFHKL-NMETGMITL-IFEPFSQSRVETERAMAAFQIIVLAKVIIDMDHITLSAR--GVT
ILADSLYSAHTPTLALTGNLIASL----AHTRSGIPDAFLTLGTVQRLFYHLYSEREEVR
AACSCALGYLSYNARAFRILLTECRNKPNQFLRIKHNISRDARINPAFLKEFQMQQ-DVG
LPSLSLEK---NGGPSVIPIFKKGK----EHRRKARPKIQPRDSLTLIPPATNFM----G
LFRTTHKTNVSHNI-FSFSSGISSDIIN---------------VSRPRIVFLKNLGKGEQ
NANPEP----------------------

------------------------------------------------------------
-----------MSQMNNVGFSTAILLTPVDPTALLDYREVHQMIRELAIGIYCLNQIPSI
SLEANYDQSSSCQLPPAYYDTRIGQILINTDYMLKALWHGIYMPKEKRARFSELWRTIMD
IDPDGKPQTNKDIFSEFSSAGLTDITKDPDFNEIYDEDVNEDPTYDPNSPEETAVFMKYA
ENIMLKLTFSTTQVQQYENVFIFETGYWLTNAIKYNQDYLDICTYQRLQQRLYLQKKIIQ
KHFEKKKDIRRGIGYLKLICFLIPFLLSLKKKMKVPYLSSLLQPFS-DDKVKTERELPPF
IYGRDFKCQNFHYKENQYFHVHGGIEFDISTPSIENALEDFQKNLEKIRDCAANTF----
IEDSGYKEYYSIPVMEFHGKSYYVIYFELETFYQQLYKTQWWGAINEIVNNLRLKRLPLT
DAQLHEQFKKKFGFKRAMKCKSIPFGMKSAVERGLSAVFHTFSRKTSSSTINVSDEAGYT
IFHHAALHNRVSIICQLCNANFKVNQRRFVTFS--------------QGPTPLHLAAQAC
SLETTVCLLCSKADYMLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLE----------
AEATAENQCTPLLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYI
IKLNIPELPVWKTLVEMLQCESY-KRRMMAVMSLEVICLAN

PF00514 // ENSGT00680000100065_0_Domain_5 (762, 800)

DQYWRCILDAGTIPALINL
LKSSKIKLQCKTVGLLSNISTHKSAVHALVEAGGIPSLINLLVCDEPEVHSRCAVILYDI
AQCE-NKDVIAKYNGIPSLINLLNLNIENVLVNVMNCIRVLCIGNENNQRAVREHKGLPY
LIRFLSSDSDVLKAVSSAAIAEVGRDNKEIQDAIAMEGAIPPLVALFKGKQISVQMKGAM
AVESLASHNALIQKAFLEKSLTKYLLKLLKAFQIDVKEQGAVALWALAGQTLKQQKYMAE
QIGYGFIINMLLSPSAKMQYV---GGEAVIALSKDSRMHQNQICEGNGIAPLVRLLRIST
IAEGTLLSVIRAVGSICIGVAHTS----NPVSQQFVVDENAFPVLIQLLRNHPSPNIKVE
V----AFSLACIVLGNDVLQKDLHENEGFEYADVLYLLHSTEKDICLRAGYALTLFAFNN
RFQQYLILESGIMTISIFERFLESTVETEKAMAAFQIVVLAEVIRDMDHITLSAR--GVT
ILVDSLYSVQTSTIVLTGNLIASL----AHSRAGIPEAFTTLGTIQRLCYHLYSGIEEVR
AACSSALGYLTYNANAFRILLKECRNKPNQLIRIKNNISRDASINPAFLKEFQMQQTLVG
LPSLSLEK---NGGPSIIPIFKRGK----EHRRKLKPKIQPKDSLTLLPPVTNFM----G
LFKATKKTKDSHNI-FSFSSTITSDITK---------------VSRPRIVCLNQLGKHVQ
KANPEPAEG-------------------

------------------------------------------------------------
-----------MSQMNNVGFSTAILLTPVDSTALLDYREVHQIIREMAVGIYCLNQIPSI
SLEANYDQSSSCQLPPAYYDTRVGQILINVDYMLKALWHGIYMPKEKRTRFSELWRAIMD
IDPDGKPQTNKDIFAEFSSAGMIDITKDPDFKGIYDEDMNEDPTYSPNSPEEKAIFMKYA
ENIMLKLTFSTTQVQQHENVFIFETGYWLTNAVKYNQDYLDICTYQRLQQRLYLQKKMIQ
KHFEKKTEIRRALGYLKLVCFLTPFMLSLKKKMKVPYLNSLLQPFS-DDKVKTERELPPF
IYGRDFKCQNFHYKEDQYFHVHGGIEFDISTPSIENALDDFKNNLERIRDCAANTF----
VEDAGYKEYYSIPVMEFNGKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXX-X-XXXXXXXXX-XXXXXXXXXXXXXXX-XXXXXXXXXXX-XXXXXXXXX
XXXXXXXXXXX---XXXXXXXXXXXXXXXXXXXX--XX-XXX-X---XXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXIIVLCRKDPSLLK----------
VEATAE

PF00023 // ENSGT00680000100065_0_Domain_3 (667, 699)

NQCTPLLLAATSGAMDTIQYLFSLGANWRKTD

ENSGT00680000100065_0_Linker_3_4 (699, 700)

N

PF00023 // ENSGT00680000100065_0_Domain_4 (700, 722)

KGNNIIHLSVLSFHTEVLKHI
IELNLPELPVWETLVXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXTIPALITL
LKGTRIKLQCKTLGLLSNIST

PF00514 // ENSGT00680000100065_0_Domain_6 (802, 842)

HGRVVRAIVGAGGVPALISLLVSDEPELHSRCAVILFDV
A

ENSGT00680000100065_0_Linker_6_7 (842, 845)

QFE

PF00514 // ENSGT00680000100065_0_Domain_7 (845, 883)

-NKDLIAQYNGIPALINLLKLDIESVLVNVMSCIRVLCVGSETNQRAMKEHKGIHY
LISFLSSDSDVLKAVSSATIAEVARN

PF00514 // ENSGT00680000100065_0_Domain_9 (927, 967)

SREVQDAIVKEGAIPPLVALFKGSQLSVQVKGAM
AVEALA

ENSGT00680000100065_0_Linker_9_10 (967, 1109)

NFNPRIQKAFLEKSLTKYLLKLLKAFQIDVKEQGAVALWALAGQTLKQQKYMAE
QIGYNFIINMLLSSSAKMQYV---GGEAVIALSKDSRIHQNQICEGNGIAPLLRLLRISK
IAEGTLLSVIRAVGSICIGVAHTS----

PF00514 // ENSGT00680000100065_0_Domain_10 (1109, 1154)

NPTSQQYIVEENGLPILIRLLRNHPSPHIKVE
V----AFSLACIVLRNDQLQFELQKSEGFEYSDVLNLLHSQEKDIRLRAGYALTLFAFNN
RFQQYLILESGMMTLSIFEPFLQSTVETEKAMAAFQIIILAKVIIDVDHITLSAR--GVN
ILVESLYSVHSTTIILTGNLIASL----SHSRAGIPEAFTTLGTIQRLCYHLYSRIEEXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXINPAFLKEFQLQQ-RVG
LPSLSLEK---NGGPSIIPVFKKGKE----HRRKLKPKIQPADSLLIPP-----------
------------------------------------------------------------
----------------------------

MLRLPKKGLPRIDQAQDEQTYLENLAVQRNASAFFENYDRSEIQELLTTALASWLSTKED
GRSQLEFPSGIMSQMNNVGFSTAILLMPVDPTALLDYREVHQIIRELAVGIYCFNQIPSI
SLEANYDQSSSCQLPPAYFDTRIGQILIHIDYMLKALWHGIYMPKEKRTRFSEMWRTIMD
VDPNGKPQTNKDIFAEFSSAGLMDITQDPDFDGIYDEDLNEDPTYDPNSAEEKAVFMKYA
EHILLKLTFSTTQVQQCENIFIFETAYWLTNAIKCTQDYLDVCTYQRLQQRLYLQIKLIQ
KHFEKKKEIRRGIGYLKLICFLVPFLLSLKKKMKVPYLNSLLQPFS-DDKVKTERELPPF
IHGRDFKCQNFHYKENQYFHVHGGIEFDITTPSIENALDDFKSNLEKIRQCAANTF----
AEDFGYREYYSIPVMEFCGKSYYVIYFELEIFYQQLYKIQWWGAINEIMDTLRVKRLPLT
EAQLHEQFKKKFGLKKAMKCKSIPFGLKSAVERGLSAVFHTFSRKTSSSTINVSDEAGYA
I

PF12796 // ENSGT00680000100065_0_Domain_1 (542, 643)

FHHAALHNRISIICHLCDANFNINQRCFITFSQ-------------RGPTPLHLAAQAC
SLETSICLLSFKADYTLSEKRGWMPIHFAAFYDNISIIIVLYRKDPTVLE----------
AEATAENQCTPLLLAATSGALDTIQYLFSLGANWRKTDTKGNNIIHLSVLTFHTEVLKYI
IQLNIPELPVWKTLVEMLQCEHF-KRRMMAVMSLEVICLAKDKYW

PF00514 // ENSGT00680000100065_0_Domain_5 (766, 800)

KCILDAGTIPALINL
LKSPKIKLQCKTVGLLSNISTHASVVHAMVEAGAIPALINLLVSEEPELHSRSAVILYDI
AQYG-NKDIISKYNGILALVNLLTLNIENVLVNVINCIRVLCIGNKNNQRAVKDHGGIQH
LIRFLSTDSDVLQASAAAAIAEVARGNKEVQDAMAQEGAVPPLVALFIGKQLSVQIKGAM
AVESLASYNPPIQKAFLEHQLTKYLLKLLKAFQIDIKEQGAVALWALAGQSLKQQKYMAE
QIGYNFIINMLLSSSAKMQYV---GGEAVMALSKDSRTHQNQICEGNGIAPLVRLLRVHK
IAEGTLLSVIRAVGSMCI------------------------------------------
V----AFSLACIVLGNDGLQKELQEIEGFKYSDVLYLLYSPNKDICLRAAYALTLFAFNN
RFQQYLILESGKITLAIFEPFLESTVETEQAMAAFQIIVLAKVIIDVDHITLSAR--GVT
ILVNSLYSNQYPTIVLTGNLIASL----AHSRAGIPAAFTTLGTVQRLCYHLYSGREEVR
TACSCALGYLTYNAHGFRILLKECRNKPNQFLRIKNNISRDASINPAFLKEFEMQQ-MVG
LPSLSLEK---NGGPSIHPVFKKGKK----HRRKAKPKIQPKDSLTLIPPVTNFM----G
LFKTTKKSKVS-DNIFSFSSAISSDII---------------SVSRPRIVCLNQLGKQEK
KANPEPGES-------------------

MLRLPKKGLPRFEQVQDEETYLENLAIQRNASAFFEKYDRSEIQELLTTALVSWLSAKED
VRSQGDLPCGIISQMNNVGFSTAILLTPVDPTALLDYREVHQMIRELAIGIYCLNQIPSI
SLEANYDQSSSCQLPPAYYDTRIGQILINIDYMLKALWHGIYMPKEKRARFSELWRTIMD
IDADGKPQTNKDIFSEFSSAGLTDITKDPDFNEIYDEDVNEDPTYDPNSPEETAVFMKYA
ENIMLKLTFSTTQVQQYENVFIFETGYWLTNAIKYNQDYLDICTYQRLQKD-------YS
KHFEKKKDIRRGIGYLKLICFLIPFLLSLKKKMKVPYLGSLLQPFS-DDKVKTERELPPF
IYGRDFKCQNFHYKENQYFHVHGGIEFDISTPSIENALEDFQKNLEKIRDCAANTF----
REDSGYKEYYSIPVMEFHGKSYYVMYFELETFYQQLYKTQWWGAINEIMNNLRPKRLPLT
DAQLHEQFKKKFGFKRAMKCKSIPFGMKSAVERGLSAVFHTFSRKTSSSTINVSDEAGYT
IFHHAALHNRVFIICQLCNANFKVNQRRFVTFG--------------QGPTPLHLAAQAC
SLETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLE----------
AEATAENQCTPLLLAATSGALDTIQYLFSIGANWRKTDTKGNNIIHLSVLTFHTEVLKYI
IKLNIPELPVWKTLVEMLQSESY-KRRMMAVMSLEVICLAN

PF00514 // ENSGT00680000100065_0_Domain_5 (762, 800)

DQYWRCILDAGTIPALINL
LKSSKIKLQCKTVGLLSNISTHKRAVHALVEAGGIPSLINLLVCDEPEVQSRCAVILYDI
AQCE-NKDVIAKYNGISSLINLLNLNIENVLVNVMNCIRVLCIGNENNQRAVREHKGLPY
LIRFLSSDSDVLKAVSSAAIAEVGR------------------------KQISVQMKGAM
AVESLASHNPLIQK----------------AFQIDVKEQGAIALWALAGQTLKQQKYMAE
QIGYSFIINMLLSPSAKMQYV---GGEAVIALSKDSRMHQNQICEGNGIAPLVRLLRIST
IAEGTLLSVIRAVGSICIGVAHTS----NPVSQQFVVDENAFPVLIQLLRNHPSPNIKVE
V----AFSLACIVLGNDVLQKDLHENEGFEYADVLYLLHSTEKDICLRAGYALTLFAFNN
RFQQYLILESGIMTISIFEPFLESTVETEKAMAAFQIVVLAKVIRDVDHITLSAR--GVT
ILVDSLYSVQTSTIVLTGNLIASL----AHSRAGIPEAFTTLGTIQRLCYHLYSGTEEVR
AACSSALGYLTYNANAFRILLKECRNKPNQFIRIKNNISRDASINPAFLKEFQMQQTLVG
LPSLSLEK---NGGPSIIPIFKKGK----DHRRKLKPKIQPRDSLTLLPPVTNFM----G
LFKATKKTKDSHNI-FSFSSTITSDITN---------------VSRPRIVCLNQLGKHVQ
KANPEPAEG-------------------

MLRLPKKGLTRFDQAQDEETYLENLAVQRNASAFFEKFDRSEVQELLATALVSWWFAKED
VRFQIDIPCGIMSQINNVGFSTAILLTPIDSSALLDYREVHQIIRELAVGIYCLNQIPSI
SLEANYDQSSSCHLPPAYYDTRIGQILINVDYMLKALWHGIYMPKEKRARFSELWRTIMD
IDPDGKPQTNRDIFAEFSSAGLTDITKDPDFDGIYDEDINEDPTYDPHSPEEKDVFMKYA
ENIMLKLTFSTTQVQQCENVFIFETAYWLTNAIKCNQDNLDICTYQRLQQRLYLQKKVIQ
KHFEKKKEIRTGIGYLKLICFLIPFLLSLKKKMKVPYLSTLLQPFSGDDKVKTERELPPF
IYGRDFKCQNFHYKENQYFHVHGGIEFDISTPPIENAMEDFQNNLEKIRDCAANIF----
AEDSGYKEYYSIPVMNFHGKSYYVICFELETFYQQLYKTQWWGAINEIVNNLKVKRLPLT
DAQLHEQFKKKFGFTKAMKCKSIPFGMKSAVERGLSAVFHTFSRKTSSSTINVSDEAGYA
IFHHAALHNRVSIICQLCNANFNVNQRRFIMFSQETDSSKSDMKKERNGPTPLHLAAQAC
SLEATICLLCYKADYMLSEKRGWMPIHFAAFYDNICIIIALCRKDPSLLE----------
AEATAENQCTPLLLAATSGALDTIQYLFSLGANWRKTDIKGNNIIHLSVLTFHTEVLKHI
IELNIPELPVWKTLVEMLQCESY-KRRMMAVMSLEVICLAKEQYW

PF00514 // ENSGT00680000100065_0_Domain_5 (766, 800)

ECILDAGTIPALINL
LKVPKIKLQCKVVGLLSNISTHVSVVEAVVVAGGIPALINLLVSEEPELHSRCALILYDI
AQLG-NKDVIAKYNGIPNLINLLKLDIEDVLINVMNCIRVLCIGNENNQRSVKDNKGIQY
LITFLSSDSDVLKAVSSATIAEVARGNTEVQDALSMEGVIPPLVALFKGKQLSVQVKGAM
AVESLASYNPAIQKEFLEKSLSKYLLKLLKAFQIDVKEQGAVALWALAGQTLKQQKYMAE
QIGYNFIINMLLSPSAKMQYVA--GGEAVIALSKDSRMHQNQICEGNGIAPLVRLLKISK
IAEGTLLSVIRAVGSICIGVAHTS----NTVSQQFVVEENALPVLIQLLRNHPSPNIKVE
V----AFSLACIVLRNDLLQNELQETEGFQYADVLYLLHSSDKNICLRAGYALSLFAFNN
RFQQYLILENGTMTISIFEPFLESTVETERAMAAFQIIVLAKVITDVDHITLSAR--GVS
ILTESLYSVHSTTIILTGNLIASL----AHSRAGIPEAFTALGTVQRLCYHLYSEKEEVR
AACACALGYLTYNANAFRILLKECRNKPNQFIRITKSISRDASINPAFLREFQMQQ-RVG
LPSLSLEK---NGGPSIIPVFKKGK----EHRRKAKPKLQPRDSLTLITPVANFM----G
LFRTTKKNTVSHNI-FSFSSATSSDIIK---------------VSRPRIVFLSQLGKNVQ
KANLEPPEAL------------------

MSRLPKKGIPRLDQVQDEETFLENLAIQRNASAFFEKYDRSEIQELLTTALVSWLSTKED
GRSQIDMPCGIMSQMNNVGFSTAILLTPVDPTALLDYREVHQMIRELAIGIYCLNQIPSI
SLEANYDQSSSCQLPPAYYDTRIGQILINIDYMLKALWHGIYMPKEKRARFSELLRTILD
IDPDGKPQTNKDIFTEFSSAGLTDITKDPDFNGIYDEDMNEDPTYDPSSPEETAVFMKYA
ENIMLKLTFSTTQVQQYENVFIFETDYWLTN-----------------------------
-----------------LICFLIPFLLNLKKKMKVPYLNSLLQPFS-DDKVKTERELPPF
IYGRDFKCQNFHYKENQYFHVHGGIEFDISTPSIENALEDFQKNLEKIRDCAANTF----
IEDSGYKEYYSIPVMEFYGKRYYVIYFVLETFYQQIYKTQWWGAINDIVNNLRLKRLPLT
DAQLHEQFKKKFGFKKAMKCKSIPFGMKSAVERGLSAVFHTFSRKTSSSTINVADEAGYT
I

PF12796 // ENSGT00680000100065_0_Domain_1 (542, 644)

FHHAALHNRVSIMCQLCNANFRVNQRRSVMFS--------------QGPTPLHLAAQAC
SLETSVCLLCFKADYTLSEERGWMPIHFAAFYDNICIVTALCRKDPISNLTLYVCLLVIL
CFLIFRNQCTPLLLAATSGALDTIQYLFSVGANWRKTDIKGNNIIHLSVLTFHTEVLKYI
IKLNIPELPVWKTLVEMLQCESY-KRRMMAVMSLEVICLAN

PF00514 // ENSGT00680000100065_0_Domain_5 (762, 800)

DQYWRCILDAGTIPALTNL
LKSSKIKLQCKTVGLLSNISTHKSVVHALVEAGGIPSLINLLVCDEPKLHSRCAVILYDI
AQCE-NKDVIAKYNGIPSLINLLNLNIESVLVNVMNCIRVLCIGNENNQRAVREHKGLPY
LIRFLSSDSDVLKAVSSAAIAEVGRDNKEIQDAIALEGAIPPLVALFKGKHISVQMKGAM
AVESLASHNPFIQKAFLEKSLTKYLLKLLKAFQIDVKEQGAVALWALAGQTLKQQKYMAE
QIGYSFIINMLLSPSAKMQYV---GNEAVIALSKDSRMHQNQICEGNGIAPLVRLLRISK
IAEGTLLSVIRAVGSICIGVAHTS----NPVSQQFVVDEKAFPVLIQLLRNHPSPNIKVE
V----AFSLACIVLGNGVLQKDLHENEGFEYADVLYLLHSTEKDICLRAGYALTLFAFNN
RFQQYIILESGIMTISIFEPFLESTIETEKAMAAFQIVILAKVIRDVDHITLSAR--GVT
ILVDSLYSVQTSTIVLTGNLIASL----AHSRAGIPEAFTTLGTIQRLCYHLYSGTEEVR
AACSSALGYLTYNANAFRILLKECRNKPNQFIRIKNNISRDASINPAFLKEFQMQQTLVG
LPSLSLEK---NGGPSIIPVFKKGK----EHRRKLKPKIQPKDSLTLLPPVTNFV----G
LFEATKKTKDSHNI-FSFSSTITSDITN---------------ISRPKIVCLNQLGKHVQ
KANPEPAEG-------------------

------------------------------------------------------------
-----------MSQMNNVGFGTVIILTPVDPTALLDYREVHQIIRELAVGIYCLNQIPAI
SLEANYDQSSSCQLPPAYYDTRIGQILINIDYMLKALWHGIYMPKEKRARFSELWRTIMD
IDPDGKPQTNKNIFAEFSSAGLIDITNDPDFSGIYDEDMNEDPTYNPNWPEEKAIFMKYA
ENIMLKLTFSTTQVQQCENVFIFETAYWLTNAIKYNQDYLDICTYQRLQQRLYLQKKVIQ
KHFEKKKEIRIGIGYLKLICFLTPFLLSLKKKMKVPYLNSLLQPFS-DDKVKTERELPPF
IYGRDFKCQNFHYKEDQYFHVHGGIEFDITTPSIENALEEFKNNLEKIRDCAANTF----
VEDAGYKEYYSIPVMEFNGKRYYVIYFELETFYQQLYKTQWWGAINEIVNNLRLKRLPLT
DAQLHEQFKKKFGFKKAMKCKSIPFGMKSAVERGLSAVFHTFSRKTSSSTINVSDE

PF00023 // ENSGT00680000100065_0_Domain_0 (537, 569)

AGYA
IFHHAALHNRVSIVCQLCNANFNVNQRR

ENSGT00680000100065_0_Linker_0_1 (569, 588)

FIMFS--------------

PF00023 // ENSGT00680000100065_0_Domain_1 (588, 620)

QGPTPLHLAAQAC
SLETTICLLSFKADYMLSE

ENSGT00680000100065_0_Linker_1_2 (620, 621)

K

PF00023 // ENSGT00680000100065_0_Domain_2 (621, 663)

RGWMPIHFAAFYDNICIIIVLCRKDPSLLE----------
AE

ENSGT00680000100065_0_Linker_2_3 (663, 667)

ATAE

PF00023 // ENSGT00680000100065_0_Domain_3 (667, 699)

NQCTPLLLAATSGALDTIKYLFSLGANWRKTD

ENSGT00680000100065_0_Linker_3_4 (699, 700)

I

PF00023 // ENSGT00680000100065_0_Domain_4 (700, 722)

RGNNIIHLSVLTFHTEVLKHI
I

ENSGT00680000100065_0_Linker_4_5 (722, 761)

ELNIPELPVWKTLVEMLQCESY-KRRMMAIMSLEVICLA

PF00514 // ENSGT00680000100065_0_Domain_5 (761, 801)

KDEYWQYILDAGTIPALINL
LKVSKIKLQCKAVGLLSNIS

ENSGT00680000100065_0_Linker_5_6 (801, 802)

T

PF00514 // ENSGT00680000100065_0_Domain_6 (802, 842)

HACVVRAVVEAGGIPALINLLVSDEPELHSRCAVILYDI
AQLE-NKDVIAKYNGIPALINLLKLDIENVLINVMHCLRVLCMR

PF00514 // ENSGT00680000100065_0_Domain_8 (885, 925)

NENNQRAVRDHKGIQY
LITFLSSDSDVLKAVSSATIAEVA

ENSGT00680000100065_0_Linker_8_9 (925, 927)

RD

PF00514 // ENSGT00680000100065_0_Domain_9 (927, 967)

NKDVQNAVAMEGAIPPLVALFKGKHLSVQVKGAM
AVESLASYNPSIQRAFLERSLSKYLLKLLKAFQIDVKEQGAVALWALAGQTLKQQKYMAE
QIGYNFIINMLLSPSAKMQYV---GGEAVIALSKDSRMHQNQICEGNGIAPLVRLLRISK
LAEGTLLSVIRAVGSICIGVAHTS----NPISQKFVVEENAFPVLIQLLRNHPSPTIKVE
V----AFSLACIVLRNNLLHKELQENEGFKYDDVLYLLHSQDKDICLRAGYALTLFAFND
CFQQYLILESGIITISIFEPFLESTIETEKAMAAFQIIILAKVIIDVDHITLSAR--GVT
ILVDSLYSVHSATIVLTGNLIASL----AHSKAGIPEAFATLGTIQRLCYHLYSGKEEXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXLEK---NGGPSIIPVFKKGK----EHRRKLKPKIQPRDSLTLMPPVTNFM----G
LFKTTQKTTASHNV-FSFSSATSSDIIK---------------VSRPRIVFLNELGKHEQ
KANSEPAEG-------------------

------------------------------------------------------------
-----------MSQLKNVGFSTAILLAPVDPNANLDYREVHQIIRELSVGIYCLNQIPSI
SLEINYDQSSSCQLPPAYFDTRXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXLLDLTKDPDYEGIYDEDMNEDPTYEPDSPEEKSIFMKYA
ENIKLKLTFSNTLVQQYDNVFLFEAAYWLTNVIRYTDDYLDICTYQRLQQRLALQKKLIE
KHLLKKSEMRQNMAYLRLICFMIPFLLSLKKKMKVPNLSTLLPPFS-DDKVKTERELPPF
IRGPDFKCQHFHYAENQYFHVHGGVEFDIGTPPIEEISEAFQELYEKLQECASQSF----
S-DLGYKEFYPIPVMEYNGKSYYVIYFELETFYQQLYKTQWWGAINEIMNNLRPKRLPLS
DXXXXXXXXXXXXXXXXXXXXSLPYGMRCAVERGLFAIFHTFCRKTSSSTISVTDE

PF00023 // ENSGT00680000100065_0_Domain_0 (537, 569)

LGYS
ILHYAALYNRVPTICQLCSSNVNVNQRR

ENSGT00680000100065_0_Linker_0_1 (569, 588)

LVMGN--------------

PF00023 // ENSGT00680000100065_0_Domain_1 (588, 620)

LGPTPLHLAAQAG
SLEATVCLLSHKADYTLYE

ENSGT00680000100065_0_Linker_1_2 (620, 621)

K

PF00023 // ENSGT00680000100065_0_Domain_2 (621, 663)

RGWLPIHVAAFYDNICIVIVLCRKDASMLE----------
AE

ENSGT00680000100065_0_Linker_2_3 (663, 667)

TAAE

PF00023 // ENSGT00680000100065_0_Domain_3 (667, 699)

NQCTPLLLAATSGALDTLHYLFSHGANWKKTD

ENSGT00680000100065_0_Linker_3_4 (699, 700)

S

PF00023 // ENSGT00680000100065_0_Domain_4 (700, 728)

KGNNIIHLSVLNFHTEVLKHI
IELNVPELPVWKTLVXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXNVMNCMRVLCIR

PF00514 // ENSGT00680000100065_0_Domain_8 (885, 925)

HVENQRAVKEHKGIAY
LISFLSSESDVLQAVSSAAIAEIARGNTDVQDAMAKEGAIIPLVKLFKGKQISVQVKGAM
AVESLASHNCAIQKEFLERSLTRYLLKLLKAFQLHVKEQGATALWALAGQTLKQQKFMAE
QIGYNFIINMLLSPSAKMQYV---GGEAVIALSKDSKLHQNQICEGNGIAPLVRLLRIGK
IAVGTLLSVIRAVGTICIXXXXXX----XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
X----XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXDICLRAGYAIALFAFNN
RYQQYLILESGAITISIFEPFLKSDIETDKAMAAFQIIVLAKVIVDVDHITLSAR--GIT
ILVDLLYSCKTDTLVLTGNLIASL----THTRAGITEAFTTLRTIQRLCYHLYSEKEEVR
ISCACALGYLTYNANAFRHLLKECRNKPNQFVRLMNNISKDASISPEFVKEFQRQK-RVG
LPSISLEI---NGGPSVIPIFKK-------------------------------------
------------------------------------------------------------
----------------------------

------------------------------------------------------------
-----------MSHINNVNFSTAILLMPVDPTALLDYRVVHQIIRELSIGIYCLNQIPSI
SLEANYDQSSSCQLPPAYYDTRIGQILICVDYMLKALWHGIYMPKEKRARFSELWRTILD
IDPDGKPQTNKDIFAEFSTAGLIDITKDPDFEGIYDDDMNEDPTYEPNSSEETALFMKYA
EHILLKLTFSTTQVQQYKNVFIFETDYWLTNAIKYNQDYLDICTYQRLQQRLYLQKKIIQ
KQLEKKADIRKGIGYLKLICFLTPFLLTLKKKMKVPYLSSLLPPFS-DDKVKTERELPPF
MYGKDFKCQNFHYREKQYFHVHGGIEFDISTPSIEEALEEFQNNLGKIQDCAANTF----
AEDSGYKEHYSIPVIECNGKSYYVICFELEVFYQQLYKTQWWGAINEIVNILRPKRLPLT
DAQLHDQFKKKFGFKKAMKCKSIPFGMKSAVERGLCAVFHTFSRKTSSSTINVSDE

PF00023 // ENSGT00680000100065_0_Domain_0 (537, 569)

GGYA
IFHHAALHNRVAIICQLCNANFNVNQRR

ENSGT00680000100065_0_Linker_0_1 (569, 588)

FIMFS--------------

PF00023 // ENSGT00680000100065_0_Domain_1 (588, 620)

QGPTPLHLAAQAC
SLEATICLLCFKADYLLSE

ENSGT00680000100065_0_Linker_1_2 (620, 621)

K

PF00023 // ENSGT00680000100065_0_Domain_2 (621, 663)

RGWMPIHFAAFYDNICIIIALCRKDPSLLEA---------
-EATAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXMLQSESY-KRRMMATMSLEVICLA

PF00514 // ENSGT00680000100065_0_Domain_5 (761, 801)

NERYWEFILDADTIPALINL
LKCPKIKLQCKTVGLLCNLS

ENSGT00680000100065_0_Linker_5_6 (801, 802)

T

PF00514 // ENSGT00680000100065_0_Domain_6 (802, 842)

HVSIVHALVEAGAIPALINLLVSEEPELHTRCAVILYDI
AQLG-NKDIIAEHXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXVLKAIASATIAEVVRDNTEVQDAVAMEGVIPPLVAIFKGKQISVQVKGAS
AVEALASHNPAIQKEFLENSLTKYLLKLLKAFKVDIKEQGAVALWALAGQTLKQQKYMAX
XXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XX
XXXXXXXXXXXXXXXXXXXXXXXX----XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVE
V----AFSLACIVLRNDLLQKELQDIEGFNYDDVLYLLDSPDKDIRLRAGYALTLFAFNN
RFQQYLILESGTMTISIFEPFLGSAIETEKAMAAFQIIILAKVIIDVDHIALSAR--GVT
ILVDCLYSDQSSTVSLTGNLIASL----AHS

PF00514 // ENSGT00680000100065_0_Domain_11 (1292, 1332)

RAGIPEAFATLGAIQRLCYHLYAKEEEVR
TACSCALGYLSYNANAFRILLKECRNKPNQFIRISSNISRDASINPAFLKEFQLQQ-RVG
LPSLSLEK---NGGPSIIPFFKK-------------------------------------
------------------------------------------------------------
----------------------------

MLRLPKKGLPRFEQVQDEETYLENLAIQRNASAFFEKYDRSEIQELLTTALVSWLSTKED
VRSQGDLPCGIMSQMNNVGFSTAILLTPVDPTALLDYREVHQMIRELAIGIYCLNQIPSI
SLEANYDQSSSCQLPPAYYDTRIGQILINIDYMLKALWHGIYMPKEKRARFSELWRTIMD
VDADGKPQTNKDIFSEFSSAGLTDITKDPDFNEIYDEDVNEDPTYDPNSPEETAVFMKYA
ENIMLKLTFSTTQVQQYENVFIFETGYWLTNAIKYNQDYLDICTYQRLQQRLYLQKKIIQ
KHFEKKKDIRRGIGYLKLICFLIPFLLSLKKKMKVPYLGSLLQPFS-DDKVKTERELPPF
IYGRDFKCQNFHYKENQYFHVHGGIEFDISTPSIENALEDFQKNLEKIRDCAANTF----
IEDSGYKEYYSIPVMEFHGKSYYVMYFELETFYQQLYKTQWWGAINEIMNNLRPKRLPLT
DAQLHEQFKKKFGFKRAMKCKSIPFGMKSAVERGLSAVFHTFSRKTSSSTINVSDEAGYT
I

PF12796 // ENSGT00680000100065_0_Domain_1 (542, 642)

FHHAALHNRVSIICQLCNANFKVNQRRFVTFG--------------QGPTPLHLAAQAC
SLETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLE----------
AEATAENQCTPLLLAATSGALDTIQYLFSIGANWRKTDTKGNNIIHLSVLTFHTEVLKYI
IKLNIPELPVWKTLVEMLQSESY-KRRMMAVMSLEVICLAN

PF00514 // ENSGT00680000100065_0_Domain_5 (762, 800)

DQYWRCILDAGTIPALINL
LKSSKIKLQCKTVGLLSNISTHKRAVRALVEAGGIPSLINLLVCDEPEVHSRCAVILYDI
AQCE-NKDVIAKYNGIPSLINLLNLNIENVLVNVMNCIRVLCIGNENNQRAVREHKGLPY
LIRFLSSDSDVLKAVSSAAIAEVGRDNKEIQDAIAMEGAIPPLVALFKGKQISVQMKGAM
AVESLASHNPLIQKAFLEKSLTKYLLKLLKAFQIDVKEQGAVALWALAGQTLKQQKYMAE
QIGYSFIINMLLSPSAKMQYV---GGEAVIALSKDSRMHQNQICEGNGIAPLVRLLRIST
IAEGTLLSVIRAVGSVCIGVAHTS----NPVSQQFVVDENAFPVLIQLLRNHPSPNIKVE
V----AFSLACIVLGNDVLQKDLHENEGFEYADVLYLLHSTEKDICLRAGYALTLFAFNN
RFQQYLILESGIMTISIFEPFLESIVETEKAMAAFQIVVLAKVIRDVDHITLSAR--GVT
ILVDSLYSVQTSTIVL--------------------------------------------
TACSCALGYLTYNANAFRILFKECRNKPNQFIRIKNNISRDASINPAFLKEFQMQQTLVG
LPSLSLEK---NGGPSIIPIFKKGK----DHRRKLKPKIQPRDSLTLLPPVTNFM----G
LFKATKKSKDSHNI-FSFSSTITSDITN---------------VSRPRIVCLNQLGKHVQ
KANPEPAEG-------------------

------------------------------------------------------------
-----------MSQINNVGFSTAILLTPVDPTALLDYREVHQIIRELSVGIYCLNQIPSI
SLEANYDQSSSCQLPPAYFDTRIGQILINIDYMLKALWHGIYMPKEKRARFSELWRTILD
IDPDGKPQTNKDIFAEFSSAGLIDITKDPDFEGIYDEDVNEDPTYNPNSPEEKAVFMKYA
ENILLKLTFSTTQVQQYENVFIFETAYWLTNAIKYNQDYLDICTYQRLQQRLYLQKKVIQ
KHLEKKQDIRRGMGYLKLICFLVPFLLSLKKKMKVPYLNSLLQPFS-DDKVKTERELPPF
IFGRDFKCQNFHYKENQYFHVHGGIEFDISTPLIESALDHFQENFEKIQDCATRTF----
EENSGYKEYYSIPVMEFHGKSYYVICFELETFYQQLYKTQWWGAINEIVNNLRPKRLPLT
DAQLHEQFKKKFGFKKAMKCKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
----XX--------XXXXXXXXXXXXXXXXXXXX--XXXXXXXXXXX

PF00023 // ENSGT00680000100065_0_Domain_1 (588, 620)

XXPTPLHLAAQAC
SLEATICLLCFKADYTLSE

ENSGT00680000100065_0_Linker_1_2 (620, 621)

K

PF00023 // ENSGT00680000100065_0_Domain_2 (621, 663)

RGWMPIHFAAFYDNICIIIALCRKDPSLLE----------
AE

ENSGT00680000100065_0_Linker_2_3 (663, 667)

TTTE

PF00023 // ENSGT00680000100065_0_Domain_3 (667, 699)

DQCTPLLLAATSGALDTIQYLFSLGANWRKTD

ENSGT00680000100065_0_Linker_3_4 (699, 700)

I

PF00023 // ENSGT00680000100065_0_Domain_4 (700, 722)

KGNNIIHLSVLTFHTEVLKHI
I

ENSGT00680000100065_0_Linker_4_5 (722, 761)

ELNIPELPVWKTLVEMLQCESY-KRRMMAVMSLEVICLA

PF00514 // ENSGT00680000100065_0_Domain_5 (761, 801)

NPRYWEYILDAGTIPALIKL
LKCPKIKLQCIVVGLLSNIS

ENSGT00680000100065_0_Linker_5_6 (801, 802)

T

PF00514 // ENSGT00680000100065_0_Domain_6 (802, 842)

HVPVVHALVAAGGIPELIHLLASEEPELHSRCAVILYDI
AELG-NKDVIAQYXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXVLKAVSSATIAEVARN

PF00514 // ENSGT00680000100065_0_Domain_9 (927, 967)

NRAMQDVLAAEGVIPPLVALFKGKQLNVQVKGAM
AVESLASYNPAIQKEFLERSLTKYLLKLLKAFKIDVKEQGAVALWALSGQTLKQQKYMAE
QIGYNFIINMLLSPSAKMQYV---GGEAVIALSKDSRMHQNQICEGNGIAPLIRLLRINK
IAEGTLLSVIRAVGSICIGVAHTN----NPISQQYIAEENAFPILIQLLQNHPSDTIKVE
V----AFSLACIVLRNDPLQNELQEAEGFTYDDVLYLLHSPDKXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXIIILAKVIIDVDHIALTAR--GVN
ILVDSLYSDQASTIVLTGNLIAS-----AHSRAGIPAFTL----GIKLCYHLYXXXXXVR
TACSCALGYLTYNANAFRILLKECRNKPNQFIRISNNISRDASINPAFLKEFELQQ-KVG
LPSLSLEK---NGGPSIIPVFKKGKE----HRRKSKPKIQPKDSLTLIPPVTNFM----G
LFRATKKTMAS-PNIFYFSSSSSSDIIK---------------VSRPRIVVLSQLGKHVQ
RASPEPPET-------------------

MIRLPKKGVPRLDQVQDEETYLENLAIQRNASALFEKYDRSEVQELLATALVSWLSSKED
VRFQIDSPCGLMSQMNTVGFSTAILLTPVDPSALLDYREVHQIIRELAVGIYCLNQIPSI
SLEANYDQSSSCHLPPAYYDTRIGQILIHIDYMLKALWHGIYMPKEKRTRFSELWRTIMD
IDPDGKPQTTKDVFSEFSSAGLVDITKDPDFSGIYDEDMNEDPTYDPNSPEEKAVFMKYA
EHIMLKMTFSTTQVQQHENVFIFETAYWLTNAIKYTQDYLDICTYQRLQQRLYLQKKVIQ
KHFEKKKEIRRGIGYLKLICFLIPFLLSLKRKMKVPYLNSLLQPFS-DDKVKTERELPPF
VYGKDFKCQNFHYKENQYFHVHGGIEFDISTPPIENALEDFKNNIQKIQDCATKTF----
AEDSGYKEHYSIPVMELNGKSYYVICFDLEIFYQQLYKTQWWGAINEIVNTLRVKRLPLT
EAQLHEQFKKKFGFKKSMKCKSIPFGMKSAVERGLSAVFHTFGRKTSSSSINVSDEAGYT
IFHHAALHNRVSVICQLCNANFNVNQRRFIMFSQ--ESSKVDMKRERNGPTPLHLAAQAC
SLEATICLLCFKADYTLSEKRGWMPIHFAAFYDNICILIALCRKEPSLLE----------
AEATAENQCTPLLLAATSGALDTIQYLFSLGANWRKTDTKGNNIIHLSVLTFHTEILKYI
IELDIPELPVWKTLVEMLQCENF-KRRMMAVMSLEVICLAKD

PF00514 // ENSGT00680000100065_0_Domain_5 (763, 800)

EYWKCILDAGTIPALVNL
LKSNRIKLLCKTVGLLSNISTHESIVHALVEAGGIQALIKLLAIDEPELHSRCAVILYDI
AHYE-NKDVIAEYNGIPALINLLDLDIENVLINVMNCIRVLCMGNEKNQKAMIEHKGIQH
LIRFLSSDSDVLKAVSSATIAEVGRNNAKVQDALATQGAIPPLVALFKGKQLSVQVKGAM
AVESLANHNYLIQKEFLERNLTKYLLKLLKAFQIDVKEQGAIALWALAGQTLKQQKYMAE
QIGYNFIINMLLSSSAKMQYV---GGEAVIALSKDSRLHQNQICEGNGIAPLVRLLRISK
IAEGTLLSVIRAVGSICLGVAHTS----NPVSQQYIVEENALPVLIQLLRKHPSPNIKVE
V----AFSLACIVLGNASLQNELQQSEGFKYSDVLDLLHSSDKDICLRAGYALTLFAFNN
RFQQYLILESGMMTISIFEPFLQSKVETEKAMAAFQIVVLAKVIIDVDHIALCAR--GVT
ILVNSLFSRNTSTIILTGNLIASL----AHSRAGIPEAFTTMGTVQRLCYHLYSGREEVR
TACSCALGYLTYNANAFRILLKECRNKPNQFLRLTNNISRDAKINPAFLKEFQMQE-MVG
LPSLSLEK---NGGPSIIPVFKKGK----EHRRKAKPKIQPKDSLTLIPPVTNFM----G
LFRKTKKTIVSHNI-FSFSSGMSSDIIN---------------VSRPRIVVLSRLGQHEH
GSYPEPTEGQ------------------

MSRLPKKGIPRLDQVQDEETFLENLAIQRNASAFFEKYDRSEIQELLTTALVSWLSTKED
GRSQVDMPCGIMSQMNNVGFSTAILLTPVDPTALLDYREVHQMIRELAIGIYCLNQIPSI
SLEANYDQSSSCQLPPAYYDTRIGQILINIDYMLKALWHGIYMPKEKRARFSELWRTILD
IDPDGKPQTNKDIFTEFSSAGLTDITKDPDFNGIYDEDMNEDPTYDPSSPEETAVFMKYA
ENIMLKLTFSTTQVQQYENVFIFETDYWLTNAIKYNQDYLDICTYQRLQQRLYLQKKIIQ
KHFEKKKDTRRGIGYLKLISFLIPFLLSLKKKMKVPYLNSLLQPFS-DDKVKTERELPPF
IYGRNFKCQNFHYKENQYFHVHGGIEFDISTPSIENALEDFQKNLEKIRDCAANTF----
IEDSGYKDYYSIPVMEFYGKRYYVIYFELETFYQQIYKTQWWGAINEIVNNLRLKRLPLT
DAQLHEQFKKKFGFKKAMKCKSIPFGMKSAVERGLSAVFHTFSRKTSSSTINVADEAGYT
IFHHAALHNRVSIICQLCNANFRVNQRRFVMFS--------------QGPTPLHLAAQAC
SLETSVCLLCFKADYTLSEKRGWMPIHFAAFYDNICIIIALCRKDPSLLE----------
AEATAENQCTPLLLAATSGALDTIQYLFSVGANWRKTDIKGNNIIHLSVLTFHTEVLKYI
IKLNIPELPVWKTLVEMLQCESY-KRRMMAVMSLEVICLAN

PF00514 // ENSGT00680000100065_0_Domain_5 (762, 800)

DQYWRCILDAGTIPALINL
LKSSKIKLQCKTVGLLSNISTHKSAVHALVEAGGIPSLINLLVCDEPELNSRCAVILYDI
AQCE-NKDVIAKYNGIPNLINLLNLNIESVLVNVMNCIRVLCIGNENNQRAVREHKGLPC
LIRFLSSDSDVLKAVSSAAIAEVGRDNKEIQDAIALEGAIPPLVALFKGKHISVQMKGAM
AVESLASHNPFIQKAFLEKSLTKYLLKLLKAFQIDVKEQGAVALWALAGQTLKQQKYMAE
QIGYSFIINMLLSPSAKMQYV---GGEAVIALSKDSRMHQNQICEGNGIAPLVRLLRISK
IAEGTLLSVIKAVGSVCIGVAHTS----NPVSQQVVVDENALPVLIYLLRNHPSPNIKVE
V----AFSLACIVLGNDMLQKDLHENEGFEYADVLYLLHSTEKDICLRAGYALTLFAFNN
RFQQYIILESGIMAISIFEPFLESTIETEKAMAAFQIVVLAKVIRDVDHITLSAR--GVT
ILVDSLYSVQTSTIVLTGNLIASL----AHSRAGIPEAFTTLGTVQRLCFHLYSGIEEVR
AACSCALGYLTYNANAFRILLKECRNKPNQFIRIKNNISRDASINPAFLKEFQLQQTLVG
LPSLSLEK---NGGPSIIPVFKKGK----EHRRKLKPKIQPKDSLTLLPPVTNFV----G
LFKATKKTKDSHNI-FSFSSTITSDITN---------------VSRPRIVCLNQLGKHVQ
KANPEPAEG-------------------

MFRIPKKGIPRFDQIQDEETYLEKLAVQRNASAFFEKYDRSEVQELLTTALVSWLSTKDD
VRSQADTPCGIMSQINNVGYSTAILLTPVDPTALLDYREVHQILRELSIGIYCLNQIPSI
SLEANYDQSSSCQLPPAYFDTRIGQILIHIDYMLKALWHGIYMPKDKRTRFSELWRTIMD
IDPDGKPQTNKDIFSEFSSAGLVDITTDPDYNGIYDEDMNEDPTYDPNSQEEKAVFMKYA
ENILMKLTFSATQVQQFENVFIFETAYWMTNAIKYNQDYLDICTYQRLQQRLYLQKKVIQ
KHFEKKKEIRRGIGYLKLICFLIPFLLSLKKKMKVPDLSSLLPPFS-DDKVKTERELPPL
IYGRDFKCQHFDYKENQYFHVHGGIEFDISTPPIEAALEDFKNNAEKIRACAADTF----
TEDSGYKEYYSIPVMEFQGKSYYVIYFKLEIFYQQLFKTQWWGAINEILSNLRLKRLPLT
EAQLHEQFKKKFGFKKAMKCKSLPFGMKSAVERGLSAVFHTFSRKTSSSTINVSDEAGYT
IFHHAALHNRVSVICQLCNSNFNVNQRRFIMFSQG-TGKFL----NPKCPTP

PF12796 // ENSGT00680000100065_0_Domain_2 (593, 697)

LHLAAQAC
SLETTICLLAFKADYTLTEKRGWMPIHFAAFYDNICIIIALCRKDPSLLE----------
AETTAENQCTPLLLAATSGALDTIQYLFSLGANWRKTDIKGNNIIHLSVLSFHTEVLKHI
VELNLPELPVWKTLVEMLQCESF-KRRMMAVMSLEVICLAKEEYW

PF00514 // ENSGT00680000100065_0_Domain_5 (766, 800)

KCILDAGTIPALVNL
LKCPRIKLQCKTVGLLSNISTHVSVVHALVEAGGIPALINLLASDEPELHARCAVILYDI
AQCE-NKDVIARYNGIPALINLLKLNIDYVLINTMNCIRVLCVGNESNQRAMRDHKGIQY
LIKFLSSDSDVLKAVASATLAEVGRENKDVQDAIVMEGAIPPLVALFKGKQLSVQVKGAM
AVESLANHNPLIQKAFLEKKLTKYLLKLLKAFQIGVKEQGAIALWALAGQTLKQQKYMAE
QIGYNFIINMLLSSSAKMQYV---GGEAVIALSKDSRLHQNQICEGNGIAPLVRLLRISK
LAEGTLLSVIRAVGSICVGVAHTS----NPMSQQYVVQENAFPVLIQLLRNHPSVYIKVE
V----AFSLACIVLGNGPLQTELQQEEGFTYFDFLYLLYSPDKEICLRAGYALTLFAFNN
CFQQYLILESGMITLSIFEPFLQSTVETDKAMAAFQIIILAKVIIDVDHITLSAR--GVK
ILVESLNSTQTSTLVLTGNLIASL----AHSRAGIPEAFITLGTIQRLCYHLYSGKEEVR
TACSCALGYMTYNANAFRILLNECRNKPYQFLRIKNNISRDASINPRFLKEFQIQQ-KVG
LPSLSLEK---NGGPSVIPVFKKGK----EHRRKAKPKIQPKDSLTLIPPVTNFV----G
LFKTTKKTMVSHNI-FSFSSVASADIIN---------------VSRPRIVCLSKLGKHKQ
TANPEPMTEG------------------

------------------------------------------------------------
-----------MSQMNNVGFSTAILLTPVDPNALLDYREVHQMIRELAVGIYCLNQIPSI
SLEANYDQSSSCQLPPAYYDTRIGQILINIDYMLKALWHGVYMPKEKRARFSELWRTIMD
VDPDGKPQTNKDIFTEFSSAGLIDITKDTDFNGIYDEDMNEDPTYDPNSPEEKAVFMKYA
ENIMLKLTFSTTQVQQYQNVFIFETAYWLTNAIKYNQDYLDICTYQRLQQRLCLQKKIIQ
KHFEKKKEIRRGLGYLKLICFLIPLLLSLKKKMKVPYLNSLLPPFS-DDKVKTERELPPF
IYGRDFRCQNFHYKDNQYFHVHGGIEFDMSTSPIENTSEEFQKNLEKIRECAANTF----
VEDSGYKEYYSIPVMEFHGKSYYVIYFELETFYQQLYKTQWWGAINEIVNNLRVKRLPLT
DTQLHEQFKKKFGFKKAMKCKSIPFGMKSAVERGLCAVFHTFSRKTSSSTVNVSDEAGYT
IFHHAALYNRVSIICQLCKANFNVNQRRFVTFS--------------QGPTPLHLAAQAC
SLETTICLLCFKADYMLSEERGWMPIHFAAFYDNICIIIALCRKDPSLLE----------
AETTTESQCTPLLLAATSGALDTIQYLFSLGANWRKTDTKGNNIVHLSVLTFHTEVLKHI
IELNIPELPVWKTLVEMLLCESY-KRRMMAVMSLEVICLAND

PF00514 // ENSGT00680000100065_0_Domain_5 (763, 800)

RYWKHILDAGTIPALINL
LKSSKIKLQCKTVGLLSNISTHKSVVHALVEAGGIPALINLLACDEPELHSRCAVILFDT
AQCE-NKDVIAKYNGIPALISLLKLDIEGVLVNVMNCIRVLCIGNENNQRAVRDHNGIQH
LIRFLSSDSDVLKAVSSATIAEVGRDNTEIQDAIALEGAIPPLVALFKGKHISVQVKGAM
AVESLASHNPLIQKAFLEKSLTKYLLKLLKAFQIDVKEQGAVALWALAGQTLKQQKYMAE
QIGYNFIINMLLSPSAKMQYV---GGEAVIALSKDSRMHQNQICEGNGIAPLVRLLRISK
IAEGTLLSVIRAVGSICIGLYAYF----QFLKYL--------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------

MLRLPKKGAPRFDQIQDEETYLENLAVQRNASAFFEKYDRSEVQELLTTALVSWLSAKED
VRSQLDIPCGIMSQMNNVGFSTAILLTPVDPTALLDYREVHQIIRELAVGIYCLNQIPSI
SLEANYDQSSSCQLPPAYYDTRIGQILINIDYMLKALWHGIYMPKEKRARFSELWRTIMD
IDPDGKPQTNRDIFAEFSSAGLIDITKDSDFNGIYDEDMNEDPTYNPNSPEEKALFMKYA
ENILLKLTFSTTQVQQYENVFIFETAYWLTNAVKYNQDYLDICTYQRLQQRLYLQKKIIQ
KHFEKKKEIRKGIGYLKLICFLTPFLLSLKKKMKVPYLSSLLQPFS-DDKVKTERELPPF
IYGRDFKCQNFHYKEDQYFHVHGGIEFDISTPSIENALEDFKNNLEKIRDCAANTF----
AEDSGYREYYSIPVLKFNGKSYYVISFELETFYQQLYKTQWWGAINEIVNNLRLKRLPLT
DAQLHEQFKKKFGFKKAMKCKSIPFGMKSAVERGLSAVFHTFSRKTSSSTINVSDEAGYA
I

PF12796 // ENSGT00680000100065_0_Domain_1 (542, 643)

FHYAALHNRVPIVCQLCNANFNVNQRRFIIVSQE-S-SKLDIKKERNGPTPLHLAAQAC
SLETAICLLCFKADYTLSEKRGWMPIHFAAFYDNICIIIVLCRKDPSLLE----------
AEATAENQCTPLLLAATSGALDTIQYLLSLGANWRKTDIKGNNIIHLSVLTFHTEVLKHI
IELNIPELPVWKTLVEMLQCESY-KRRMMAVMSLEVICLANDGY

PF00514 // ENSGT00680000100065_0_Domain_5 (765, 800)

WKSILDAGTIPALINL
LKGTKIKLQCKTVGLLSNISTHASVVHALVEAGAIPALINLLVSDEPELHSRCAVILYDI
AQFE-NKDVIAKCNGIPALINLLNLDIESVLVNVMNCIRVLCMGNENNQRAVRDHKGIPY
LITFLSSDSDVLKAVSSVTIAEVARDNKEVQDAMAMEGAIPPLVALFKGKQLSVQVKGAV
AVEALASSNPAIQRAFLEKSLSKYLLKLLKAFQIDIKEQGAVALWALAGQTLKQQKYMAE
QIGYNFIINMLLSPSAKMQYV---GGEAVIALSKDSRIHQNQICEGNGIAPLVRLLRISK
IAEGTLLSVIRAVGSICIGVAHTS----NPISQQYVVDENAFPVLIQLLRNHPSPNIKVE
V----AFSLACIVLRNDLLQNELQGNEGFNYADVLYLLHSQDKDICLKAGYALTLFAFNN
RFQQYLMLESGRITISIFEPFLESTVETEKAMAAFQIIILAKVIIDVDHITLTAR--GIT
ILVDSLYSDHSTTIALTGNLIASL----AHSRAGIPEAFTTLGTIQRLCYHLYSGQEEVR
MACSSALGYLTYNANAFRILLKECRNKPNQFLRITNNISRDASINPMFLKEFQMQQ-RVG
LPSLSLER---NGGPSIIPVFKKGK----EHRRKLKPKIQPRDSLTSIPPVTNFM----G
LFKTTKKTTVSHNV-FSFSSAISSDIIN---------------VSRPRIVLLSQLGKHVQ
NANSEPAEG-------------------

MLRLSKKGIVRIDQVQDEETYLENLAVQRNASAFFEKYDRSEVQELLTTALVSWLSAKED
VRSQLDIPCGLMSQINNVGFSTAILLTPVDPTAHLDYREVHQILRELAVGIYCLNQIPSI
SLEANYDQSSSCQLPPAYYDTRIGQILIYIDYMLKALWHGIYMPKEKRTRFSELWRTIMD
IDPDGKPQTTKDIFSEFSSAGLVDITNDPDFDGIYDEDMNEDPTYDPNSPEEKAVFMKYA
ENIMLKLTFSTTQVQQHENIFIFETAYWLTNAIKYNQDYLDICTYQRLQQRLYLQKKVIQ
KHFEKKKEIRRGIGYLKLICFLIPFLLSLKKRMKVPYLNSLLPPFS-DDKVKTERELPPF
IYGRDFKCQNFDYKEHQYFHVHGGIEFDISTNPVENALDDFKKNVEKIQECAANTF----
AEDSGYKEFYSVPVMEFYGKSYYVIYFDLEIFYQQLYKTQWWGAINEIINNLRLKRLPLT
EAQLHEQFKKKFGFKKAIKCKSIPFGMKSAVERGLSAVFHTFSRKTSSSTINVSDEAGYA
IFHHAALHNRVSIICQLCNANFNVNQRRFVMFSQ--ESSKVDMKKERNGPTPLHLAAQAC
SLEATICLLCFKADYTLTEKRGWMPIHFAAFYDNICIIIALCRKDPSLLE----------
AEATAENQCTPLLLAATSGALDTIQYLFSLGANWRKTDTKGNNIIHLSVLTFHTEVLKYI
IELNIPELPVWKTLVEMLQCESF-KRRMMAVMSLEVVCLA

PF00514 // ENSGT00680000100065_0_Domain_5 (761, 800)

NDQYWKYILDAGTIPALINL
LKCPKIKLQCKTVGLLSNISTHISVVHALVEAGGIPALINLLASDEPELHSRCAVILYDI
AKCE-NKDVISKYNGIPALINLLSLNIESVLVNVMNCIRVLCIGNESNQRAMRDHNGIQY
LIRFLSSDSDALKAVSSATIAEVGRDNKDVQDAIAMQGAIPPLVALFKGKQLSVQVKGAM
AVESLANCNPFIQKAFLERKLTKDLLKLLKAFQIDVKEQGAVALWALAGQTLKQQKYMAE
QIGYNFIINMLLSPSAKMQYV---GGEAVIALSKDSRIHQNQICEGNGIAPLVRLLRINK
IAEGTLLSVIRAVGSICIGVAHTS----NPMSQRFVVEENAFPVLIQLLRSHPSTNIKVE
V----AFSLACIVLGNELLQKELQEKEGFKYSDVLYLLHSKEKDICLRAGYALTLFAFNN
RFQQYLILESGMLTLSIFEPFLRSKVETEKAMAAFQIIVLAKVIIDVDHITLSAR--GVT
ILVDSLYSVHIPTIVLTGNLIASL----AHSRAGIPAAFLTLGTVQRLCYHLYSGREEVR
TACSCALGYLTYNAHAFRILLTECRNKPNQFLRIMNNISRDAKINPTFLKEFQMQQ-NVG
LPSLSLEK---NGGPSIIPVFKKGK----EHRRKTRPKIQPRDSLTLIPPVTNFM----G
LFKTTKQATVSHNI-FSFSSGISSDIIN---------------VSRPRIVCLNNLGKREQ
KANPEPTES-------------------

MLRLPKKGLPRFEQVQDEETYLENLAIQRNASAFFEKYDRSEIQELLTTALVSWLSTKED
VRSQGDLPCGIMSQMNNVGFSTAILLTPVDPTALLDYREVHQMIRELAIGIYCLNQIPSI
SLEANYDQSSSCQLPPAYYDTRIGQILINIDYMLKALWHGIYMPKEKRARFSELWRTIMD
IDADGKPQTDKDIFSEFSSAGLTDITKDPDFNEIYDEDVNEDPTYDPNSPEETAVFMKYA
ENIMLKLTFSTTQVQQYENVFIFETGYWLTNAIKYNQDYLDICTYQRLQQRLYLQKKIIQ
KHFEKKKDIRRGIGYLKLICFLIPFLLSLKKKMKVPYLGSLLQPFS-DDKVKTERELPPF
IYGRDFKCQNFHYKENQYFHVHGGIEFDISTPSIENALEDFQKNLEKIRDCAANTF----
IEDSGYKEYYSIPVMEFHGKSYYVMYFELETFYQQLYKTQWWGAINEIMNNLRPKRLPLT
DAQLHEQFKKKFGFKRAMKCKSIPFGMKSAVERGLSAVFHTFSRKTSSSTINVSDEAGYT
I

PF12796 // ENSGT00680000100065_0_Domain_1 (542, 642)

FHHAALHNRVSIICQLCNANFKVNQRRFVTFG--------------QGPTPLHLAAQAC
SLETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLE----------
AEATAENQCTPLLLAATSGALDTIQYLFSIGANWRKTDTKGNNIIHLSVLTFHTEVLKYI
IKLNIPELPVWKTLVEMLQSESY-KRRMMAVMSLEVICLAN

PF00514 // ENSGT00680000100065_0_Domain_5 (762, 800)

DQYWRCILDAGTIPALINL
LKSSKIKLQCKTVGLLSNISTHKRAVRALVEAGGIPSLINLLVCDEPEVHSRCAVILYDI
AQCE-NKDVIAKYNGIPSLINLLNLNIENVLVNVMNCIRVLCIGNENNQRAVREHKGLPY
LIRFLSSDSDVLKAVSSAAIAEVGRDNKEIQDAIAMEGAIPPLVALFKGKQISVQMKGAM
AVESLASHNPLIQKAFLEKSLTKYLLKLLKAFQIDVKEQGAVALWALAGQTLKQQKYMAE
QIGYSFIINMLLSPSAKMQYV---GGEAVIALSKDSRMHQNQICEGNGIAPLVRLLRIST
IAEGTLLSVIRAVGSICIGVAHTS----NPVSQQFVVDENAFPVLIQLLRNHPSPNIKVE
V----AFSLACIVLGNDVLQKDLHENEGFEYADVLYLLHSTEKDICLRAGYALTLFAFNN
RFQQYLILESGIMTISIFEPFLESIVETEKAMAAFQIVVLAKVIRDVDHITLSAR--GVT
ILVDSLYSVQTSTIVLTGNLIASL----AHSRAGIPEAFTTLGTIQRLCYHLYSGTEEVR
AACSCALGYLTYNANAFRILFKECRNKPNQFIRIKNNISRDASINPAFLKEFQMQQTLVG
LPSLSLEK---NGGPSIIPIFKKGK----DHRRKLKPKIQPRDSLTLLPPVTNFM----G
LFKATKKSKDSHNI-FSFSSTITSDITN---------------VSRPRIVCLNQLGKHVQ
KANPEPAEG-------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------LTDITKDPDFNEIYDEDVNEDPTYDPNSPEETAVFMKYA
ENIMLKLTFSTTQIQQYENVFIFETGYWLTNAIKYNQDYLDICTYQRLQQRLYLQKKIIQ
KHFEKKKDIRRGIGYLKLICFLIPFLLSLKKKMKVPYLSSLLQPFS-DDKVKTERELPPF
IYGRDFKCQNFHYKENQYFHVHGGIEFDISTPSIENALEDFQKNLEKIRDCAANTF----
IEDSGYKEYYSIPVMEFHGKSYYVIYFELETFYQQLYKTQWWGAINEIVNNLRLKRLPLT
DAQLHEQFKKKLGFKRAMKCKSIPFGMKSAVERGLSAVFHTFSRKTSSSTISVSDEAGYT
IFHHAALHNRVSIICQLCNANFKVNQRRFVTFS--------------QGPTP

PF12796 // ENSGT00680000100065_0_Domain_2 (593, 697)

LHLAAQAC
SLETTVCLLCSKADYTLS-KRGWMPIHFAAFYDNVCIIIALCRKDPSLLE----------
AEATAENQCTPLLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYI
IKLNIPELPVWKTLVEMLQCESY-KRRMMAVMSLEVICLAN

PF00514 // ENSGT00680000100065_0_Domain_5 (762, 800)

DQYWRCILDAGTIPALINL
LKSSKIKLQCKTVGLLSNISTHKSAVHALVEAGGIPSLINLLVCDEPEVHSRCAVILYDI
AQCE-NKDVIAKYNGIPSLINLLNLNIENVLVNVMNCIRVLCIGNENNQRAVREHKGLPY
LIRFLSSDSDVLKAVSSAAIAEVGRDNKEIQDAIAMEGAIPPLVALFKGKQISVQMKGAM
AVESLASHNALIQKAFLEKSLTKYLLKLLKAFQIDVKEQGAVALWALAGQTLKQQKYMAE
QIGYSFIINMLLSPSAKMQYV---GGEAVIALSKDSRMHQNQICEGNGIAPLVRLLRIST
IAEGTLLSVIRAVGSICIGVAHTS----NPVSQQFVVDENAFPVLIQLLRNHPSPNIKVE
V----AFSLACIVLGNDVLQKDLHENEGFEYADVLYLLHSTEKDICLRAGYALTLFAFNN
RFQQYLILESGIMTISIFERFLESTVETEKAMAAFQIVVLAKVIRDMDHITLSAR--GVT
ILVDSLYSVQTSTIVLTGNLIASL----AHSRAGIPEAFTTLGTIQRLCYHLYSGIEEVR
AACSSALGYLTYNANAFRILLKECRNKPNQFIRIKNNISRDASINPAFLKEFQMQQTLVG
LPSLSLEK---NGGPSIIPIFKRGK----EHRRKLKPKIQPKDSLTLLPPVTNFM----G
LFKATKKTKDSHNI-FSFSSTITSDITN---------------VSRPRIVCLNQLGKHVQ
KANPEPAEG-------------------