Query Results 

--------------------------SWVGFIASFRGTVPYGLSLEIGDTVQILEKCDGW
YRGFALKNPNIKGIFPSS--YVHLKNACV

PF16172 // ENSGT00610000085806_3_Domain_1 (90, 451)

KNKGQFEMVIPTEDSVITEMTSTLRDWGTMW
KQLYVRNEGDLFHRLWHIMNEILDLRRQVLVGHLTHDRMKDVKRHITARLDWGNEQLGLD
LVPRKEYAMVDPEDISITELYRL---------------------------------MEHR
HRKKDTPVQASSHHLFVQMKSLMCSNLGEELEVIFSLFDSKENRPISERFFLRLNRNGLP
KAPDKPERHCSLFVDLGSSELKKDIYITVHIIRI---GRMGAGEKKNACSVQYRRPFG--
CAVLSIADLLTGETKDDLILKVYMCNTESEWYQIHENIIKKLNARYNLTGSNAGLAVSLQ
LLHGDIE-QIRREYSSVFSHGVSITRKLGF

ENSGT00610000085806_3_Linker_1_3 (451, 456)

SNIIM

PF14429 // ENSGT00610000085806_3_Domain_3 (456, 652)

PGEMRNDLYITIERGEFEKGGKSVA
RNVEVTMFIVDSSGQTLKDFISFGSGE------PPASEYHSFVLYH--NNSPRWSELLKL
PIPVDKFRGAHIRFEFRHCSTKEK---GEKKLFGFSFVPLMQEDGRTLPDGTHELIVHKC
EENTNLQDTTRYLKLPFSKGI-FLGNNNQAMKATKESFCITSFLCSTKLTQ

ENSGT00610000085806_3_Linker_3_5 (652, 1250)

N---GDMLD
LLKWRTHP----------DKITGCLSKLKEIDGSEIVKFLQDTLDTLFGILDENSQKYGS
KVFDSLVHIINLLQDSKFHHFKPVMDTYIESHFAGA--LAYRDLIKVLKWYVDRITEAER
QEHIQEVLKAQEYIFKYIVQSRRLFSLATGGQNEEEFRCCIQELLMSVRFFLSQESKGSG
ALSQSQAVFLSSFPAVYSELLKLFDVREVANLVQDTLGSLPTILHVDDSLQAIKLQCIGK
TVE-SQLYTNPDSRYILLPVVLHHLHIHLQEQKDLIMCARILSNVFCLIKKNSSEKSVLE
EIDVIVASLLDILLRTILEITSRPQPSSSAMRFQFQDVTRTGFLNKESLHDSSTLSTFSF
CADTYGKVPMTGRH--------TGEFVACLLSLLRQMTDRHYQQLLDSFNTKEELRDFLL
QIFTV-----FRILIRP-----EMF-PKDWTVMRLVA---NN-VIITTVLYLSDALRKNF
LNENFDYKIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKYG-----DMRVTMGCEIF
SMWQNLGEHKLHFIPALIGPFLEVTLIPQPDLRNVMIPIFHDMM-----

PF06920 // ENSGT00610000085806_3_Domain_5 (1250, 1759)

-DWEQRRSGNF
KQVEAKLIDKLDSLMSEGKGDETYRELFNSIIPLFGP---YPSLLKKIERETWRESGVSL
IATVTRLMERLLDYRDCMKMGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHL
KAQNFTEAAYTLLLYDELLEWSDRPLREFLTYPMQTEWQRKEHLHLTIIQNFDRGKCWEN
GIILCRKIAEQYESYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLR
NKEFVCRGHDYERLEAFQQRMLNEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPIPES
QEVLQREGVPDNIKSFYKVNHIWKFRYDRPFHKGTKDKENEFKSLWVERTSLYLVQSLPG
ISRWFEVEKREVVEMSPLENAIEVLENKNQQLKTLISQCQTRQMQNINPLTMCLNGVIDA
AVNGGVSRYQEAFFVKEYILSHPEDGEKIARLRELMLEQ---AQILEFGLAVHEKFVPQD
MRPLHKKLVDQFFVMKSSLGIQEFSACMQASPVHFPNGSPRVCRNSAPASVSPDGTRVIP
RR---SPLSYPAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQ--------------
--------PSPSTSSLSSTHSASPNVTSSAPSSARASPLLSDKHKHSRENSCLSPRERPC
SAIYPTPVEPS-------------------------------------------------
-------QRMLFNHIGDG-ALPRSDPNLSAPEKAVNPTPSSWSLDSGKEAKNMSDSGKLI
SPPVPPRPTQTASPARHTTSV-SPSPAGRSPLK----------------GSVQSFTPSPV
EYH--SPGLISNSPVLSGSYSSGISSLSRCSTSETSGFENQVNEQSVPLPVPV-------
----PVPVPV-YGGEEPVRKESKTPPPYSVYERTLRRPVPLPHSLSIPV------TPEPP
ALPPKPLAARSSHLENG-ARRTDPGPRPRPLPRKVSQL-

------------------MWIPTEHEK

PF07653 // ENSGT00610000085806_3_Domain_0 (28, 82)

YGVVIASFRGTVPYGLSLEIGDTVQILEKCDGW
YRGFALKNPNVKGIFPSS--YVHLKNACVKNKGQFEMVIPTEDSVITEMTSTLRDWGTMW
KQLYVRNEGDLFHRLWHIMNEILDLRRQVLVGHLTHDRMKDVKRHITARLDWGNEQLGLD
LVPRKEYAMVDPEDISITELYRL---------------------------------MEHR
HRKKDTPVQASNHHLFVQMKSLMCSNLGEELEVIFSLFDSKENRPISERFFLRLNRNGLP
KAPDKPERHCSLFVDLGSSELRRDIYITVHIIRI---GRMGAGEKKNACSVQYRRPFG--
CAVLSIADLLTGETKDDLILKVYMCNTESEWYQIHENIIKKLNARYNLTGSNAGLAVSLQ
LLHGDIE-QIRREYSSVFSHGVSITRKLGFSNII

PF14429 // ENSGT00610000085806_3_Domain_3 (455, 657)

MPGEMRNDLYITIERGEFEKGGKSVA
RNVEVTMFIVESSGQILKDFISFGSGE------PPASEYHSFVLYH--NNSPRWSELLKL
PIPVDKFRGAHIRFEFRHCSTKEK---GEKKLFGFSFVPLMQEDGRTLPDGTHELIVHKC
EENTNLQDTARYLKLPFSKGI-LLGNNHQAMKATKESFWITSFLCSTKLTQN---GDMLD
LLKWRTHP----------DKITGCLSKLKEIDGSEIVKFLQDTLDTLFGILDENSQKYGS
KVFDSLVHIINLLQDSKFHHFKPVMDTYIESHFAGA--LAYRDLIKVLKWYVDRITEAER
QEHIQEVLKAQEYIFKYIVQSRRLFSLATGGQNEEEFRCCIQELLMSVRFFLSQESKGSG
ALSQSQAVFLSSFPAVYSELLKLFDVREVANLVQDTLGSLPTIVHVDDSLQAVKLQCIGK
TVE-SQLYTNPDSRYILLPVVLHHLHMHLQEQKDLIMCARILSNVFCLIKKNSSEKSVLE
EIDVIVASLLDILLRTILEITSRPQPSGSAMRLQFQDV----------------------
----------------------TGEFVACLLSLLRQMTDRHYQQLLDSFNTKEELRDFLL
QIFTV-----FRILIRP-----EMF-PKDWTVMRLVA---NN-VIITTVLYLSDALRKNF
LNENFDYKIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKYG-----DMRVTMGCEIF
SMWQNLGEHKLHFIPALIGPFLEVTLIPQPDLRNVMIPIFHDMM------DWEQRRSGNF
KQVEAKLIDKLDSLMSEGKGDETYRELFNSI------------LLKKIERETWRESGVSL
IATVTRLMERLLDYRDCMKMGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHL
KAQNFTEAAYTLLLYDELLEWSDRPLREFLTYPMQTEWQRKEHLHLAIIQNFDRGKCWEN
GIILCRKIAEQYESYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLR
NKEFVCRGHDYERLEAFQQRMLNEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPIPES
QEVLQREGVPDNIK

PF06920 // ENSGT00610000085806_3_Domain_5 (1575, 1759)

SFYKVNHIWKFRYDRPFHKGTKDKENEFKSLWVERTSLYLVQSLPG
ISRWFEVEKREVVEMSPLENAIEVLENKNQQLKTLISQCQTRQMQNINPLTMCLNGVIDA
AVNGGVSRYQEAFFVKEYILSHPEDGEKIARLRELMLEQ---AQILEFGLAVHEKFVPQD
MRPLHKKLVDQFFVMKSSLGIQEFSACIQASPVHFPNGSPRVCRNSAPASLSPDGPRVIP
RR---SPLSYPAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQ--------------
--------PSPSTSSLSSTHSASPNVTSSAPSSARASPLLSDKHKHSRENSCLSPRERPC
SAIYPTPVEPS-------------------------------------------------
-------QRLLFNHIAEG-ALPRSDPNLSAPEKAVNPTPSSWSLDSGKEAKNMSDSGKIL
SPPVPPRPTQTASPARHTTSV-SPSPAGRSPLKQ---------------GSGQGFTPSPV
EYQ--SPGLTSHSPVLSGSYSSGISSLSRCSTSETSGFESQAPEGPAQA-----------
--------AG-PGAEEPGRRESRTPPPYSVYERTLRRPGPLPHSLSIPVAVAVAATVEPP
ALPPKPPAPRPGPPENG-PRRTEPGPRPRPLPRKVSQL-

-----------------IWIK-KKFR

PF00018 // ENSGT00610000085806_3_Domain_0 (27, 85)

KFLAVIASFRGTVPYGLSLEIGDTVQILEKCDGW
YRGFALKNPNIKGIFPSS--YVHLKHAGVKNKGQFEMVIPTEDSVITEMTSTLRDWGTMW
KQLYVRNEGDLFHRLWHIMNEVLDLRRQVLVGHLTHDRMKDVKRHITARLDWGNEQLGLD
LVPRKEYAMVDPEDISITELYRL---------------------------------MEHR
HRKKDAPAQASSHHLFVQLKSLMCSNLGEELEVVFSLFDSRENRPISERFFLRLNRNGLP
KAPDKPERHCSLFVDLSSGELRRDIYITVHIIRI---GRMGAGEKKNACSVQYRRPFG--
CAVLSIADLLTGETKDDLILKVYMCNTESEWHQIHENIIKKLNARYNLTGSNAGLAVSLQ
LLHGDLE-QIRREYPSVFSHGVSITRKLGFSNIIMPGEMRNDLYITVERGEFEKGGKSVA
RNVEVTMFIVESGGQTLKDFISFGSGE------PPASEYHSFVLYH--NNSPRWAELLKL
PIPVDKFRGAHIRFEFRHCSTKEK---GEKKLFGFSFIPLMQEDGRTLPDGTHELIVHKC
EENTSLQDPTRYLKLPFSKGL-LLGTSSLAPKTTKESFWITSFLCSTKLTQN---GDMLD
LLKWRTHP----------DKIPGCLSKLKEIDGSEIVKFLQDTLDTLFGILDENSQKYGS
KVFDSLVHIINLLQDSKFHHFKPVMDTYIESHFAGA--LAYRDLIKVLKWYVDRITEAER
QEHIQEVLKAQEYIFKYIVQSRRLFSLATGGQHEEEFRCCIRELLLSVRFFLSQESKGAG
PLSQSQAVFLSSFPAVYSELLKLFDVREVANLVQDTLGSLPTLLHVDETLQAVKLQCIGQ
TVE-SQLYTNPDSRCILLPVVLHHLHMHLRQQKDLVACARILSNVFCLSKKNSSEKSVLE
EIDVIVASLLDILLRTILEITSRPQASGPATRLHFQDVTTGLCSAGSPRAHGPGRITC--
---KGSSICNHEGPKAVVQSKSLGEFVACLLSLLRQMTDRHYQQLLDSFSTKEELRDFSG
RTLSA-----KKFCDLPGQA-GTFF-ALSWTQRGRIRRLMNLKTIVLTAVCMLHQQAESF
CRTTLSPKAWPLTCITICIYFQQRFMQPH---PVLRKKIDRKHKDINKRAPMLKLGCKY-
LCWTRHGEVLAATRAAP---------------RGVHIPFVSICLETPLAQGSRERALLGV
LQVEAKLIDKLDSLMSEGKGDETYRELFNSIIPLFGP---YPSLLKKIERETWRESGVSL
IATVTRLMERLLDYRDCMKVGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHL
KAQNFTEAAYTLLLYDELLEWSDRPLREFLSYPAQTEWQR-EHLHLAIIQNFDRGKCWEN
GIVLCRKIAEQYESYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLR
NKEFVCRGHDYERLEAFQQRMLTEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPIPES
QEVLQRDGVPDNIKSFYKVNRIWKFRYDRPFHKGPKDKENEFKSLWVERTSLFLVQSLPG
ISRWFEVDKREVVEMTPLENAIEVLENKNQQLKTLISQCRTRQMQNINPLTMCLNGVIDA
AVNGGVSRYQEAFFVKEYILSHPEDGEKIARLQELMLEQ---AQILECGLAVHEKFVPQD
MRPLHKKLVDQFFMMKSSLGIQEFSACIQASPVHFPNGSPRVCRNSAPASMSPDGSRVIP
RR---SPLSYPAINRYSSSSLSSQASAEVSNITGQSESSDEVFNMQ--------------
--------PSPSTSSLSSTHSASPNVTSSAPSSARASPLLSDKHKHSRENACLSPRERPC
SAIYPTPVEPS-------------------------------------------------
-------QRLLFNHIGDG-AMPRSDPNLSAPEKAVNPTPSSWSLDSGKEARSMAESGRLL
SPPVPPRPALTASPARHTAPV-SPSPAGRSPLK---------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------

------------------PLIPVSHALDPAIIASFRGTVPHGLSLEIGDTVQILEKCDGW
YRGFALKNPNIKGIFPSS--YVHLKNACV

PF16172 // ENSGT00610000085806_3_Domain_1 (90, 451)

KNKGQFEMVIPTEDSVITEMTSTLRDWGTMW
KQLYVRNEGDLFHRLWHIMNEILDLRRQVLVGHLTHDRMKDIKRHITARLDWGNEQLGLD
LVPRKEYAMVDPEDISITELYRL---------------------------------MEHR
HRKKDTPVQASSHHLFVQMKSLMCSNLGEELEVIFSLFDSKENRPISERFFLRLNRNGLP
KAPDKPERHCSLFMDLGSSELRKDIYITVHIIRI---GRMGAGEKKNACSVQYRRPFG--
CAVLSIADLLTGETKDDLVLKVYMCNTESEWYQIHENIIKKLNARYNLTGSNAGLAVSLQ
LLHGDIE-QIRREYSSVFSHGVSITRKLGF

ENSGT00610000085806_3_Linker_1_3 (451, 456)

SNIIM

PF14429 // ENSGT00610000085806_3_Domain_3 (456, 652)

PGEMRNDLYITIERGEFEKGGKSVA
RNVEVTMFIVDSSGQTLKDFISFGSGE------PPASEYHSFVLYH--NNSPRWSELLKL
PIPVDKFRGAHIRFEFRHCSTKEK---GEKKLFGFSFVPLMQEDGRTLPDGTHELIVHKC
EENTNLQDTTRYLKLPFSKGI-FLGNNNQAMKATKESFWITSFLCSTKLTQ

ENSGT00610000085806_3_Linker_3_5 (652, 1250)

N---GDMLD
LLKWRTHP----------DKITGCLSKLKEIDGSEIVKFLQDTLDTLFGILDENSQKYGS
KVFDSLVHIINLLQDSKFHHFKPVMDTYIESHFAGA--LAYRDLIKVLKWYVDRITEAER
QEHIQEVLKAQEYIFKYIVQSRRLFSLATGGQNEEEFRCCIQELLMSVRFFLSQESKGSG
ALSQSQAVFLSSFPAVYSELLKLFDVREVANLVQDTLGSLPTIMHVDDSLQAIKLQCIGK
TVE-SQLYTNPDSRYILLPVVLHHLHIHLQEQKDLIMCARILSNVFCLIKKNSSEKSVLE
EIDVIVASLLDILLRTILEITSRPQPSSSAMRLQFQDV----------------------
----------------------TGEFVACLLSLLRQMTDRHYQQLLDSFNTKEELRDFLL
QIFTV-----FRILIRP-----EMF-PKDWTVMRLVA---NN-VIITTVLYLSDALRKNF
LNENFDYKIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKYG-----DMRVTMGCEIF
SMWQNLGEHKLHFIPALIGPFLEVTLIPQPDLRNVMIPIFHDMM-----

PF06920 // ENSGT00610000085806_3_Domain_5 (1250, 1759)

-DWEQRRSGNF
KQVEAKLIDKLDSLMSEGKGDETYRELFNSIIPLFGP---YPSLLKKIERETWRESGVSL
IATVTRLMERLLDYRDCMKMGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHL
KAQNFTEAAYTLLLYDELLEWSDRPLREFLTYPMQTEWQRKEHLHLTIIQNFDRGKCWEN
GIILCRKIAEQYESYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLR
NKEFVCRGHDYERLEAFQQRMLNEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPMPES
QEVLQREGVPDNIKSFYKVNHIWKFRYDRPFHKGTKDKENEFKSLWVERTSLYLVQSLPG
ISRWFEVEKREVVEMSPLENAIEVLENKNQQLKTLISQCQTRQMQNINPLTMCLNGVIDA
AVNGGVSRYQEAFFVKEYILSHPEDGEKIARLRELMLEQ---AQILEFGLAVHEKFVPQD
MRPLHKKLVDQFFVMKSSLGIQEFSACIQASPVHFPNGSPQVCRNSAPASMSPDGTRVIP
RR---SPLSYPAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQ--------------
--------PSPSTSSLSSTHSASPNVTSSAPSSARASPLLSDKHKHSRENSCLSPRERPC
SAIYPTPGEPS-------------------------------------------------
-------QRMLFNHIGDGGASPRSDPNLSAPEKAVNPTPSSWSLDSGKEAKNMSDSGKLI
SPPVPPRPTQTASPARHTTA-VSPSPAGRSPLK----------------GSVQSFTPSPV
EYH--SPGLTSNSPVLSGSYSSGISSLSRCSMSETSGFENQVNDQPAPATVP--------
--------G-YSGPEEPARKESKTPPPYSVYERTLRRPVPLPHSLSIP----------PP
ALPPKPLAARAGHLENG-TRRTEPGPRPRPLPRKVSQL-

-----------------------------PLIASFRGTVPYGLSLEIGDTVQILEKCDGW
YRGFALKNPNIKGIFPSS--YVHLKNACV

PF16172 // ENSGT00610000085806_3_Domain_1 (90, 451)

KNKGQFEMVIPTEDSVITEMTSTLRDWGTMW
KQLYVRNEGDLFHRLWHIMNEILDLRRQVLVGHLTHDRMKDVKRHITARLDWGNEQLGLD
LVPRKEYAMVDPEDISITELYRL---------------------------------MEHR
HRKKDTPVQASSHHLFVQMKSLMCSNLGEELEVIFSLFDSKENRPISERFFLRLNRNGLP
KAPDKPERHCSLFVDLGSSELRKDVYITVHIIRI---GRMGAGEKKNACSVQYRRPFG--
CAVLSIADLLTGETKDDLILKVYMCNTESEWYQIHENIIKKLNARYNLTGSNAGLAVSLQ
LLHGDIE-QIRREYSSVFSHGVSITRKLGF

ENSGT00610000085806_3_Linker_1_3 (451, 456)

SNIIM

PF14429 // ENSGT00610000085806_3_Domain_3 (456, 652)

PGEMRNDLYITIERGEFEKGGKSVA
RNVEVTMFIVDSSGQTLKDFISFGSGE------PPASEYHSFVLYH--NNSPRWSELLKL
PIPVDKFRGAHIRFEFRHCSTKEK---GEKKLFGFSFVPLMQEDGRTLPDGTHELIVHKC
EENTNLQDTTRYLKLPFSKGI-FLGNNNQAMKATKESFCITSFLCSTKLTQ

ENSGT00610000085806_3_Linker_3_5 (652, 1250)

N---GDMLD
LLKWRTHP----------DKITGCLSKLKEIDGSEIVKFLQDTLDTLFGILDENSQKYGS
KVFDSLVHIINLLQDSKFHHFKPVMDTYIESHFAGA--LAYRDLIKVLKWYVDRITEAER
QEHIQEVLKAQEYIFKYIVQSRRLFSLATGGQNEEEFRCCIQELLMSVRFFLSQESKGSG
ALSQSQAVFLSSFPAVYSELLKLFDVREVANLVQDTLGSLPTILHVDDSLQAIKLQCIGK
TVE-SQLYTNPDSRYILLPVVLHHLHIHLQEQKDLIMCARILSNVFCLIKKNSSEKSVLE
EIDVIVASLLDILLRTILEITSRPQPSSSAMRFQFQDVTRTGFLNRESLHDSSTLSTFSF
CADTYGKLPMTGRH--------TGEFVACLLSLLRQMTDRHYQQLLDSFNTKEELRDFLL
QIFTV-----FRILIRP-----EMF-PKDWTVMRLVA---NN-VIITTVLYLSDALRKNF
LNENFDYKIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKYG-----DMRVTMGCEIF
SMWQNLGEHKLHFIPALIGPFLEVTLIPQPDLRNVMIPIFHDMM-----

PF06920 // ENSGT00610000085806_3_Domain_5 (1250, 1759)

-DWEQRRSGNF
KQVEAKLIDKLDSLMSEGKGDETYRELFNSIIPLFGP---YPSLLKKIERETWRESGVSL
IATVTRLMERLLDYRDCMKMGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHL
KAQNFTEAAYTLLLYDELLEWSDRPLREFLTYPMQTEWQRKEHLHLTIIQNFDRGKCWEN
GIILCRKIAEQYESYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLR
NKEFVCRGHDYERLEAFQQRMLNEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPIPES
QEVLQREGVPDNIKSFYKVNHIWKFRYDRPFHKGTKDKENEFKSLWVERTSLYLVQSLPG
ISRWFEVEKREVVEMSPLENAIEVLENKNQQLKTLISQCQTRQMQNINPLTMCLNGVIDA
AVNGGVSRYQEAFFVKEYILSHPEDGEKIARLRELMLEQ---AQILEFGLAVHEKFVPQD
MRPLHKKLVDQFFVMKSSLGIQEFSACMQASPVHFPNGSPRVCRNSAPASVSPDGTRVIP
RR---SPLSYPAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQ--------------
--------PSPSTSSLSSTHSASPNVTSSAPSSARASPLLSDKHKHSRENSCLSPRDRPC
SAIYPTPVEPS-------------------------------------------------
-------QRMLFNHIGDG-ALPRSDPNLSAPEKAVNPTPSSWSLDSGKEAKNMSDSGKLI
SPPVPPRPTQTASPARHTTSV-SPSPAGRSPLK----------------GSVQSFTPSPV
EYH--SPGLISNSPVLSGSYSSGISSLSRCSTSETSGFENQVNEQSVPLPVPV-------
----PVPMPV-YGGEEPVRKESKTPPPYSVYERTLRRPVPLPHSLSIPV------TPEPP
ALPPKPLAARSSHLENG-ARRTDPGPRPRPLPRKVSQL-

--------------MWIP----TEHEK

PF07653 // ENSGT00610000085806_3_Domain_0 (28, 82)

YGVVIASFRGTVPYGLSLEIGDTVQILEKCDGW
YRGFALKNPNIKGIFPSS--Y

ENSGT00610000085806_3_Linker_0_1 (82, 90)

VHLKNACV

PF16172 // ENSGT00610000085806_3_Domain_1 (90, 451)

KNKGQFEMVIPTEDSVITEMTSTLRDWGTMW
KQLYVRNEGDLFHRLWHIMNEILDLRRQVLVGHLTHDRMKDVKRHITARLDWGNEQLGLD
LVPRKEYAMVDPEDISITELYRL---------------------------------MEHR
HRKKDTPVQASSHHLFVQMKSLMCSNLGEELEVIFSLFDSKENRPISERFFLRLNRNGLP
KAPDKPERHCSLFVDLGSSELRKDIYITVHIIRI---GRMGAGEKKNACSVQYRRPFG--
CAVLSIADLLTGETKDDLVLKVYMCNTESEWYQIHENIIKKLNARYNLTGSNAGLAVSLQ
LLHGDIE-QIRREYSSVFSHGVSITRKLGF

ENSGT00610000085806_3_Linker_1_3 (451, 456)

SDIIM

PF14429 // ENSGT00610000085806_3_Domain_3 (456, 652)

PGEMRNDLYITVERGEFEKGGKSVA
RNVEVTMFIVDSNGQPLKDFISFGSGE------PPASEYHSFVLYH--NNSPRWSELLKL
PIPVDKFRGSHIRFEFRHCSTKEK---GEKKLFGFSFVPLMQEDGRTLPDGTHELIVHKC
EENTNLQDTTRYLKLPFSKVI-FLGNNNQTMKATKESFWITSFLCSTKLTQ

ENSGT00610000085806_3_Linker_3_5 (652, 1250)

N---GDMLD
LLKWRTHP----------DKITGCLSKLKEIDGSEIVKFLQDTLDTLFGILDENSQKYGS
KVFDSLVHIINLLQDSKFHHFKPVMDTYIESHFAGA--LAYRDLIKVLKWYVDRITEAER
QEHIQEVLKAQEYIFKYIVQSRRLFSLATGGQNEEEFRCCIQELLMSVRFFLSQESKGTG
ALSQSQAVFLSSFPAVYSELLKLFDVREVANLVQDTLGSLPTIMHVDDSLQAIKLQCIGK
TVE-SQLYTNPDSRYILLPVVLHHLHIHLQEQKDLIMCARILSNVFCLIKKNSSEKSVLE
EIDVIVASLLDILLRTILEITSRPQASSSAMRLQFQDV----------------------
----------------------TGEFVACLLSLLRQMTDRHYQQLLNSFSTKEELRDFLL
QIFTV-----FRILIRP-----EMF-PKDWTVMRLVA---NN-VIITTVLYLSDALRKNF
LNENFDYKIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKYG-----DMRVTMGCEIF
SMWQNLGEHKLHFIPALIGPFLEVTLIPQPDLRNVMIPIFHDMM-----

PF06920 // ENSGT00610000085806_3_Domain_5 (1250, 1757)

-DWEQRRSGNF
KQVEAKLIDKLDSLMSEGKGDETYRELFNSIIPLFGP---YPSLLKKIERETWRESGVSL
IATVTRLMERLLDYRDCMKIGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHL
KAQNFTEAAYTLLLYDELLEWSDRPLREFLTYPMQTEWQRKEHLHLTIIQNFDRGKCWEN
GIILCRKIAEQYESYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLR
NKEFVCRGHDYERLEAFQQRMLNEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPIPES
QEVLQREGVPDNIKSFYKVNHIWKFRYDRPFHKGTKDKENEFKSLWVERTSLYLVQSLPG
ISRWFEVEKREVVEMSPLENAMEVLENKNQQLKTLISQCQTRQMQNINPLTMCLNGVIDA
AVNGGVSRYQEAFFVKDYILSHPEDGEKIARLRELMLEQ---AQILEFGLAVHEKFVPQD
MRPLHKKLVDQFFVMKSSFGIQEFPACIQASPVHFPNGSPRVCRNSAPASMSPDGTRVIP
RR---SPLSYPAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQ--------------
--------PSPSTSSLSSTHSASPNVTSSAPSSARASPLLSDKHKHSRENSCLSPRDRPC
SAIYPTPVEPS-------------------------------------------------
-------QRMLFNHIGDG-ALPRSDPNLSAPEKAVNPTPSSWSLDSGKEAKNMSDSGKLI
SPPVPPRPTQTASPARHTTSV-SPSPAGRSPLK----------------GSVQSFTPSPV
EYN--SPGLSSNSPVLSGSYSSGISSLSRCSTSETSGFENQANEQSVPV----PVPV--P
--VPVPVPSF-SGSEEPVRKESKTPPPYSVYERTLRRPVPLPHSLSIPV------TSEPP
ALPPKPLAARSSHLENG-TRRTDPGPRPRPLPRKVSQL-

------------------MWIPTEHEK

PF07653 // ENSGT00610000085806_3_Domain_0 (28, 82)

YGVVIASFRGTVPYGLSLEIGDTVQILEKCDGW
YRGFALKNPNVKGIFPSS--Y

ENSGT00610000085806_3_Linker_0_1 (82, 90)

VHLKNACV

PF16172 // ENSGT00610000085806_3_Domain_1 (90, 451)

KNKGQFEMVIPTEDSVITEMTSTLRDWGTMW
KQLYVRNEGDLFHRLWHIMNEILDLRRQVLVGHLTHDRMKDVKRHITARLDWGNEQLGLD
LVPRKEYAMVDPEDISITELYRL---------------------------------MEYR
HRKKDTPVQASSHHLFVQMKSLMCSNLGEELEVIFSLYDSKENRPISERFFLRLNRNGLP
KAPDKPERHCSLFLDLGSSELRKDIYITVHIIRI---GRMGAGEKKNACSVQYRRPFG--
CAVLSIADLLTGETKDDLVLKVYMCNTESEWNQIHENIIKKLNARYNLTGSNAGLAVSLQ
LLHGDIE-QIRREYSSVFSHGVSITRKLGF

ENSGT00610000085806_3_Linker_1_3 (451, 456)

SNIIM

PF14429 // ENSGT00610000085806_3_Domain_3 (456, 652)

PGEMRNDLYITIERGEFEKGGKSVA
RNVEVTMFIVDSGGQTLKDFISFGSGE------PPASEYHSFVLYH--NNSPRWSELLKL
PIPVDKFRGAHIRFEFRHCSTKEK---GEKKLFGFSFVPLMQEDGRTLPDGTHELIVHKC
EENTNLQDPTRYLKLPFSKGI-FLGNNNQTMKATKESFWITSFLCSTKLTQ

ENSGT00610000085806_3_Linker_3_5 (652, 1250)

N---GDMLD
LLKWRTHP----------DKITGCLSKLKEIDGSEIVKFLQDTLDTLFGILDENSQKYGS
KVFDSLVHIINLLQDSKFHHFKPVMDTYIESHFAGA--LAYRDLIKVLKWYVDRITEAER
QEHIQEVLKAQEYIFKYIVQSRRLFSLATGGQNEEEFRCCIQELLMSVRFFLSQESKGSG
ALSQSQAVFLSSFPAVYSELLKLFDVREVANLVQDTLGSLPTIMHVDDSLQAIKLQCIGK
TVE-SQLYTNPDSRYILLPVVLHHLHIHLQEQKDLIMCARILSNVFCLIKKNSSEKSVLE
EIDVIVASLLDILLRTILEITSRPQPSSSTMRLQFQDV----------------------
----------------------TGEFVACLLSLLRQMTDRHYQQLLDSFSTKEELRDFLL
QIFTV-----FRILIRP-----EMF-PKDWTVMRLVA---NN-VIITTVLYLSDALRKNF
LNENFDYKIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKYG-----DMRVTMGCEIF
SMWQNLGEHKLHFIPALIGPFLEVTLIPQPDLRNVMIPIFHDMM-----

PF06920 // ENSGT00610000085806_3_Domain_5 (1250, 1759)

-DWEQRRSGNF
KQVEAKLIDKLDSLMSEGKGDETYRELFNSIIPLFGP---YPSLLKKIERETWRESGVSL
IATVTRLMERLLDYRDCMKMGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHL
KAQNFTEAAYTLLLYDELLEWSDRPLREFLTYPMQTEWQRKEHLHLTIIQNFDRGKCWEN
GIILCRKIAEQYESYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLR
NKEFVCRGHDYERLEAFQQRMLNEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPIPES
QEVLQREGVPDNIKSFYKVNHIWKFRYDRPFHKGTKDKENEFKSLWVERTSLYLVQSLPG
ISRWFEVEKREVVEMSPLENAIEVLENKNQQLKTLISQCQTRQMQNINPLTMCLNGVIDA
AVNGGVSRYQEAFFVKEYILSHPEDGEKIARLRELMLEQ---AQILEFGLAVHEKFVPQD
MRPLHKKLVDQFFVMKSSLGIQEFSACIQASPVHFPNGSPRVCRSSVPASMSPDGTRVIP
RR---SPLSYPAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQ--------------
--------PSPSTSSLSSTHSASPNVTSSAPSSARASPLLSDKHKHSRENSCLSPRERPC
SAIYPTAVEPS-------------------------------------------------
-------QRMLLNHIGDG-ALPRSDPNLSAPEKAVNPTPSSWSLDSGKEAKNMSDSGKLI
SPPVPPRPTQTASPARHTTSV-SPSPAGRSPLK----------------GSAQSFTPSPV
EYH--SPGLTSNSPVLSGSYSSGISSLSRCSTSETSGFENQVNEQSVSLSSF--------
-------GGP-GGPEEPVCKESKTPPPYSVYERTLRRPVPLPHSLSIPA------TSEPP
ALPPKPLAARPGHLENG-TRRTEPGPRPRPLPRKVSQL-

------------------------------------------------------------
------------------------------------MVIPTEDSVITEMTSTLRDWGTMW
KQLYVRNEGDLFHRLWHIMNEILDLRRQVLVGHLTHDRMKDVKRHITARLDWGNEQLGLD
LVPRKEYAMVDPEDISITELYRL---------------------------------MEHR
HRKKDTPVQASSHHLFVQMKSLMCSNLGEELEVIFSLFDSKENRPISERFFLRLNRNGLP
KAPDKPERHCSLFVDLGSSELRKDIFITVHIIRI---GRMGAGEKKNACSVQYRRPFG--
CAVLSIADLLTGETKDDLILKVYMCNTESEWYQIHENIIKKLNARYNLTGSNAGLAVSLQ
LLHGDIE-QIRREYSSVFSHGVSITRKLGFSNIIMPGEMRNDLYITIERGEFEKGGKSVA
RNVEVTMFIIDSSGQNLKDFISFGSGE------PPASEYHSFVLYH--NNSPRWAELLKL
PIPVDKFRGAHIRFEFRHCSTKEK---GEKKLFGFSFVPLMQEDGRTLPDGTHELIVHKC
EENTNLQDTTRYLKLPFSKGI-FLGNNNQAMKATKESFWITSLLCSTKLTQN---GDMLD
LLKWRTHP----------DKITGCLSKLKEIDGSEIVKFLQDTLDTLFGILDENSQKYGS
KVFDSLVHIINLLQDSKFHHFKPVMDTYIESHFAGA--LAYRDLIKVLKWYVDRITEAER
QEHIQEVLKAQEYIFKYIVQSRRLFSLATGGQNEEEFRCCIQELLMSVRFFLSQESKGSG
ALSQSQAVFLSSFPAVYSELLKLFDVREVANLVQDTLGSLPTIMHVDDSLQAIKLQCIGK
TVE-SQLYTNPDSRYILLPVVLHHLHIHLQEQKDLIMCARILSNVFCLIKKNSSEKSVLE
EIDVIVASLLDILLRTILEITSRPQPSGSSMRLQFQDV----------------------
----------------------TGEFVACLLSLLRQMTDRHYQQLLDSFNTKEELRDFLL
QIFTV-----FRILIRP-----EMF-PKDWTVMRLVA---NN-VIITTVLYLSDALRKNF
LNENFDYKIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKYG-----DMRVTMGCEIF
SMWQNLGEHKLHFIPALIGPFLEVTLIPQPDLRNVMIPIFHDMM------DWEQRRSGSF
KQVEAKLIDKLDSLMSEGKGDETYRELFNSIIPLFGP---YPSLLKKIERETWRESGVSL
IATVTRLMERLLDYRDCMKMGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHL
KAQNFTEAAYTLLLYDELLEWSDRPLREFLTYPMQTEWQRKEHLHLTIIQNFDRGKCWEN
GIILCRKIAEQYENYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLR
NKEFVCRGHDYERLEAFQQRMLNEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPMPES
QEVLQREGVPDNIK

PF06920 // ENSGT00610000085806_3_Domain_5 (1575, 1759)

SFYKVNHIWKFRYDRPFHKGTKDKENEFKSLWVERTSLYLVQSLPG
ISRWFEVEKREVVEMSPLENAIEVLENKNQQLKTLIGQCQTRQMQNINPLTMCLNGVIDA
AVNGGVSRYQEAFFVKEYILSHPEDGEKIARLRELMLEQ---AQILEFGLAVHEKFVPQD
MRPLHKKLVDQFFVMKSSLGIQEFTACIQASPVHFPNGSPRVCRNSAPASMSPDGTRVIP
RR---SPLSYPAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQ--------------
--------PSPSTSSLSSTHSASPNVTSSAPSSARASPLLSDKHKHSRENSCLSPRERPC
SAIYPTPVEPS-------------------------------------------------
-------QRMLFNHIGDG-GLPRSDPNLSAPEKAVNPTPSSWSLDSGKEAKNMSDSGKLI
SPPVPPRPTQTASPARHTTTSVSPSPAGRSPLKQ---------------GSVQSFTPSPV
EYH--S-------PVLSGSYSSGISSLSRCSTSETSGFENQVNEQSAPPPTPAPAPAPAP
GSGPAPVPSYGGGPEEPVRKESKTPPPYSVYERTLRRPVPLPHSLSIPA------AAEPP
ALPPKPLASRPSHLENG-TRRTEAGPRPRPLPRKVSQL-

--------------MWIP----TEHEK

PF07653 // ENSGT00610000085806_3_Domain_0 (28, 82)

YGVVIASFRGTVPYGLSLEIGDTVQILEKCDGW
YRGFALKNPNIKGIFPSS--Y

ENSGT00610000085806_3_Linker_0_1 (82, 90)

VHLKNACV

PF16172 // ENSGT00610000085806_3_Domain_1 (90, 451)

KNKGQFEMVIPTEDSVITEMTSTLRDWGTMW
KQLYVRNEGDLFHRLWHIMNEILDLRRQVLVGHLTHDRMKDVKRHITARLDWGNEQLGLD
LVPRKEYAMVDPEDISITELYRL---------------------------------MEHR
HRKKDTPVQASSHHLFVQMKSLMCSNLGEELEVIFSLFDSKENRPISERFFLRLNRNGLP
KAPDKPERHCSLFVDLGSSELRKDIYITVHIIRI---GRMGAGEKKNACSVQYRRPFG--
CAVLSIADLLTGETKDDLVLKVYMCNTESEWYQIHENIIKKLNARYNLTGSNAGLAVSLQ
LLHGDIE-QIRREYSSVFSHGVSITRKLGF

ENSGT00610000085806_3_Linker_1_3 (451, 456)

SDIIM

PF14429 // ENSGT00610000085806_3_Domain_3 (456, 652)

PGEMRNDLYITVERGEFEKGGKSVA
RNVEVTMFIVDSNGQPLKDFISFGSGE------PPASEYHSFVLYH--NNSPRWSELLKL
PIPVDKFRGSHIRFEFRHCSTKEK---GEKKLFGFSFVPLMQEDGRTLPDGTHELIVHKC
EENTNLQDTTRYLKLPFSKVI-FLGNNNQTMKATKESFWITSFLCSTKLTQ

ENSGT00610000085806_3_Linker_3_5 (652, 1250)

N---GDMLD
LLKWRTHP----------DKITGCLSKLKEIDGSEIVKFLQDTLDTLFGILDENSQKYGS
KVFDSLVHIINLLQDSKFHHFKPVMDTYIESHFAGA--LAYRDLIKVLKWYVDRITEAER
QEHIQEVLKAQEYIFKYIVQSRRLFSLATGGQNEEEFRCCIQELLMSVRFFLSQESKGTG
ALSQSQAVFLSSFPAVYSELLKLFDVREVANLVQDTLGSLPTIMHVDDSLQAIKLQCIGK
TVE-SQLYTNPDSRYILLPVVLHHLHIHLQEQKDLIMCARILSNVFCLIKKNSSEKSVLE
EIDVIVASLLDILLRTILEITSRPQASSSAMRLQFQDV----------------------
----------------------TGEFVACLLSLLRQMTDRHYQQLLNSFSTKEELRDFLL
QIFTV-----FRILIRP-----EMF-PKDWTVMRLVA---NN-VIITTVLYLSDALRKNF
LNENFDYKIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKYG-----DMRVTMGCEIF
SMWQNLGEHKLHFIPALIGPFLEVTLIPQPDLRNVMIPIFHDMM-----

PF06920 // ENSGT00610000085806_3_Domain_5 (1250, 1757)

-DWEQRRSGNF
KQVEAKLIDKLDSLMSEGKGDETYRELFNSIIPLFGP---YPSLLKKIERETWRESGVSL
IATVTRLMERLLDYRDCMKIGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHL
KAQNFTEAAYTLLLYDELLEWSDRPLREFLTYPMQTEWQRKEHLHLTIIQNFDRGKCWEN
GIILCRKIAEQYESYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLR
NKEFVCRGHDYERLEAFQQRMLNEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPIPES
QEVLQREGVPDNIKSFYKVNHIWKFRYDRPFHKGAKDKENEFKSLWVERTSLYLVQSLPG
ISRWFEVEKREVVEMSPLENAIEVLENKNQQLKTLISQCQTRQMQNINPLTMCLNGVIDA
AVNGGVSRYQEAFFVKDYILSHPEDGEKIARLRELMLEQ---AQILEFGLAVHEKFVPQD
MRPLHKKLVDQFFVMKSSFGIQEFPACIQASPVHFPNGSPRVCRNSAPASMSPDGTRVIP
RR---SPLSYPAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQ--------------
--------PSPSTSSLSSTHSASPNVTSSAPSSARASPLLSDKHKHSRENSCLSPRDRPC
SAIYPTPVEPS-------------------------------------------------
-------QRMLFNHIGDG-ALPRSDPNLSAPEKAVNPTPSSWSLDSGKEAKNMSDSGKLI
SPPVPPRPTQTASPARHTTSV-SPSPAGRSPLK----------------GSVQSFTPSPV
EYN--SPGLSSNSPVLSGSYSSGISSLSRCSTSETSGFENQANEQSVPV----PVPV--P
--VPVPVPSF-SGSEEPVRKESKTPPPYSVYERTLRRPVPLPHSLSIPV------TSEPP
ALPPKPLAARSSHLENG-TRRTEPGPRPRPLPRKVSQL-

--------------VWV--------EEEKYMIASFRGTVPYGLSLEIGDTVQILEKCDGE
WPGVL-----LEGIFPSS--YVHLKNACV

PF16172 // ENSGT00610000085806_3_Domain_1 (90, 451)

KNKGQFEMVIPTEDSVITEMTSTLRDWGTMW
KQLYVRNEGDLFHRLWHIMNEILDLRRQVLVGHLTHDRMKDVKRHITARLDWGNEQLGLD
LVPRKEYAMVDPEDISITELYRL---------------------------------MEHR
HRKKDTPVQASCHHLFVQMKSLMCSNLGEELEVIFSLFDSKENRPISERFFLRLNRNGLP
KAPDKPERHCSLFVDLGSSELRKDIYITVHIIRI---GRMGAGEKKNACSVQYRRPFG--
CAVLSIADLLAGETKDDLILKVYMCNTESEWYQIHENIIKKLNARYNLTGSNAGLAVSLQ
LLHGDIE-QIRREYSSVFSHGVSITRKLGF

ENSGT00610000085806_3_Linker_1_3 (451, 456)

SNIIM

PF14429 // ENSGT00610000085806_3_Domain_3 (456, 652)

PGEMRNDLYITIERGEFEKGGKSVA
RNVEVTMFIVDSSGLPLKDFISFGSGE------PPASEYHSFVLYH--NNSPRWSELLKL
PIPVDKFRGAHIRFEFRHCSTKEK---GEKKLFGFSFVPLMQEDGRTLPDGTHELIVHKC
EENTNLQDTTRYLKLPFSKGI-FLGNNNQAMKATKESFWITSFLCSTKLTQ

ENSGT00610000085806_3_Linker_3_5 (652, 1250)

N---GDMLD
LLKWRTHP----------DKITGCLSKLKEIDGSEIVKFLQDTLDTLFGILDENSQKYGS
KVFDSLVHIINLLQDSKFHHFKPVMDTYIESHFAGA--LAYRDLIKVLKWYVDRITEAER
QEHIQEVLKAQEYIFKYIVQSRRLFSLATGGQNEDEFRCCIQELLMSVRFFLSQESKGSR
ALSQSQAVFLSSFPAVYSELLKLFDVREVANLVQDTLGSLPTIMHVDDSLQAIKLQCIGK
TVE-SQLYTNPDSRYILLPVVLHHLHIHLQEQKDLIMCARILSNVFCLIKKNSSEKSVLE
EIDVIVASLLDILLRTILEITSRPQPSSSAMRLQFQDVTSSRNRQSLC------GDPTLS
---TFPVFAD------TYMKKCHGEFVACLLSLLRQMTDRHYQQLLDSFNTKEDLRDFLL
QIFTV-----FRILIRP-----EMF-PKDWTVMRLVA---NN-VIITTVLYLSDALRKNF
LNENFDYKIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKYG-----DMRVTMGCEIF
SMWQNLGEHKLHFIPALIGPFLEVTLIPQPDLRNVMIPIFHDMM-----

PF06920 // ENSGT00610000085806_3_Domain_5 (1250, 1759)

-DWEQRRSGNF
KQVEAKLIDKLDSLMSEGKGDETYRELFNSIIPLFGP---YPSLLKKIERETWRESGVSL
IATVTRLMERLLDYRDCMKMGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHL
KAQNFTEAAYTLLLYDELLEWSDRPLREFLTYPMQTEWQRKEHLHLTIIQNFDRGKCWEN
GIILCRKIAEQYESYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLR
NKEFVCRGHDYERLEAFQQRMLNEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPIPES
QEVLQREGVPDNIKSFYKVNHIWKFRYDRPFHKGTKDKENEFKSLWVERTSLYLVQSLPG
ISRWFEVEKREVVEMSPLENAIEVLENKNQQLKTLISQCQTRQMQNINPLTMCLNGVIDA
AVNGGVSRYQEAFFVKEYILSHPEDGEKIARLRELMLEQ---AQILEFGLAVHEKFVPQD
MRPLHKKLVDQFFVMKSSLGIQEFSACIQASPVHFPNGSPRVCRNSAPASMSPDGTRVIP
RR---SPLSYPAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQ--------------
--------PSPSTSSLSSTHSASPNVTSSAPSSARASPLLSDKHKHSRENSCLSPRERPC
SAIYPTPVEPS-------------------------------------------------
-------QRMLFNHIGDG-ALPRSDPNLSAPEKAVNPTPSSWSLDSGKEAKNMSDSGKLI
SPPVPPRPTQTASPARHTTAV-SPSPAGRSPMK----------------GSVQSFTPSPV
EYH--SPGLTSNSPVLSGSYSSGISSLSRCSTSETSGFENQVNEQSAAAPG---------
-----------PGPEEPVRKESKTPPPYSVYERTLRRPVPLPHSLSIPV------AAEPP
ALPPKPLAARPGHLENG-TRRTEPGPRPRPLPRKVSQL-

---------------M---WIPTEHEK

PF07653 // ENSGT00610000085806_3_Domain_0 (28, 82)

YGVVIASFRGTVPYGLSLEIGDTVQILEKCDGW
YRGFALKNPNIKGIFPSS--Y

ENSGT00610000085806_3_Linker_0_1 (82, 90)

VHLKNACV

PF16172 // ENSGT00610000085806_3_Domain_1 (90, 451)

KNKGQFEMVIPTEDSVITEMTSTLRDWGTMW
KQLYVRNEGDLFHRLWHIMNEILDLRRQVLVGHLTHDRMKDVKRHITARLDWGNEQLGLD
LVPRKEYAMVDPEDISITELYRL---------------------------------MEHR
HRKKDTPMQASSHHLFVQMKSLMCSNLGEELEVIFSLFDSKENRPISERFFLRLNRNGLP
KAPDKPERHCSLFVDLGSSDLRKDIYITVHIIRI---GRMGAGEKKNACSVQYRRPFG--
CAVLSIADLLTGETKDDLVLKVYMCNTESEWYQIHENIIKKLNARYNLTGSNAGLAVSLQ
LLHGDIE-QIRREYSSVFSHGVSITRKLGF

ENSGT00610000085806_3_Linker_1_3 (451, 456)

SNIIM

PF14429 // ENSGT00610000085806_3_Domain_3 (456, 652)

PGEMRNDLYITVERGEFEKGGKSVA
RNVEVTMFIVDSNGLPLKDFISFGSGE------PPASEYHSFVLYH--NNSPRWSELLKL
PIPVDKFRGSHIRFEFRHCSTKEK---GEKKLFGFSFVPLMQEDGRTLPDGTHELIVHKC
EENTNLQDTTRYLKLPFSKVI-FLGNNNQTMKATKESFWITSFLCSTKLTQ

ENSGT00610000085806_3_Linker_3_5 (652, 1250)

N---GDMLD
LLKWRTHP----------DKITGCLSKLKEIDGSEIVKFLQDTLDTLFGILDENSQKYGS
KVFDSLVHIINLLQDSKFHHFKPVMDTYIESHFAGA--LAYRDLIKVLKWYVDRITEAER
QEHIQEVLKAQEYIFKYIVQSRRLFSLATGGQNEEEFRCCIQELLMSVRFFLSQESKGAG
ALSQSQAVFLSSFPAVYSELLKLFDVREVANLVQDTLGSLPTIVHVDDSLQAIKLQCIGK
TVE-SQLYTNPDSRYILLPVVLHHLHIHLQEQKDLIMCARILSNVFCLIKKNSSEKSVLE
EIDVIVASLLDILLRTILEITSRPQATSSAMRLQFQDV----------------------
----------------------TGEFVACLLSLLRQMTDRHYQQLLNSFNTKEELRDFLL
QIFTV-----FRILIRP-----EMF-PKDWTVMRLVA---NN-VIITTVLYLSDALRKNF
LNENFDYKIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKYG-----DMRVTMGCEIF
SMWQNLGEHKLHFIPALIGPFLEVTLIPQPDLRNVMIPIFHDMM-----

PF06920 // ENSGT00610000085806_3_Domain_5 (1250, 1757)

-DWEQRRSGNF
KQVEAKLIDKLDSLMSEGKGDETYRELFNSIIPLFGP---YPSLLKKIERETWRESGVSL
IATVTRLMERLLDYRDCMKMGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHL
KAQNFTEAAYTLLLYDELLEWSDRPLREFLTYPMQTEWQRKEHLHLTIIQNFDRGKCWEN
GIILCRKIAEQYESYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLR
NKEFVCRGHDYERLEAFQQRMLNEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPIPES
QEVLQREGVPDNIKSFYKVNHIWKFRYDRPFHKGTKDKENEFKSLWVERTSLYLVQSLPG
ISRWFEVEKREVVEMSPLENAIEVLENKNQQLKALISQCQTRQMQNINPLTMCLNGVIDA
AVNGGVSRYQEAFFVKDYILSHPEDGEKIARLRELMLEQ---AQILEFGLAVHEKFVPQD
MRPLHKKLVDQFFVMKSSFGIQEFPACIQASPVHFPNGSPRVCRNSAPASMSPDGTRVIP
RR---SPLSYPAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQ--------------
--------PSPSTSSLSSTHSASPNVTSSAPSSARASPLLSDKHKHSRENSCLSPRDRPC
SAIYPTPVEPS-------------------------------------------------
-------QRTLFNHIGDG-ALPRSDPNLSAPEKAVNPTPSSWSLDSGKEAKNMSDGGKLI
SPPVPPRPTQTASPARHTTP-VSPSPVGRSPLK----------------GSVQSFTPSPV
EYN--SPGLSSNSPVLSGSYSSGISSLSRCSTSETSGFENQANEQSVAMPGPVP------
VSVPMPVPSF-SGSEEPVRKESKTPPPYSVYERTLRRPVPLPHSLSIPV------TSEPP
ALPPKPLAARSSHLENG-TRRTEPGPRPRPLPRKVSQL-

-----------------------------PLIASFRGTVPYGLSLEIGDTVQILEKCDGW
YRGFALKNPNIKGIFPSS--YVHLKNACV

PF16172 // ENSGT00610000085806_3_Domain_1 (90, 451)

KNKGQFEMVIPTEDSVITEMTSTLRDWGTMW
KQLYVRNEGDLFHRLWHIMNEILDLRRQVLVGHLTHDRMKDVKRHITARLDWGNEQLGLD
LVPRKEYAMVDPEDISITELYRL---------------------------------MEHR
HRKKDTPVQASSHHLFVQMKSLMCSNLGEELEVIFSLFDSKENRPISERFFLRLNRNGLP
KAPDKPERHCSLFVDLGSSELRKDIYITVHIIRI---GRMGAGEKKNACSVQYRRPFG--
CAVLSIADLLTGETKDDLILKVYMCNTESEWYQIHENIIKKLNARYNLTGSNAGLAVSLQ
LLHGDIE-QIRREYSSVFSHGVSITRKLGF

ENSGT00610000085806_3_Linker_1_3 (451, 456)

SNIIM

PF14429 // ENSGT00610000085806_3_Domain_3 (456, 652)

PGEMRNDLYITIERGEFEKGGKSVA
RNVEVTMFIVDSSGQTLKDFISFGSGE------PPASEYHSFVLYH--NNSPRWSELLKL
PIPVDKFRGAHIRFEFRHCSTKEK---GEKKLFGFSFVPLMQEDGRTLPDGTHELIVHKC
EENTNLQDTTRYLKLPFSKGI-FLGNNNQAMKATKESFCITSFLCSTKLTQ

ENSGT00610000085806_3_Linker_3_5 (652, 1250)

N---GDMLD
LLKWRTHP----------DKITGCLSKLKEIDGSEIVKVYSISL--LFSLI---------
---------------------RPIL-------HSAHFPLYFRDLIKVLKWYVDRITEAER
QEHIQEVLKAQEYIFKYIVQSRRLFSLATGGQNEEEFRCCIQELLMSVRFFLSQESKGSG
ALSQSQAVFLSSFPAVYSELLKLFDVREVANLVQDTLGSLPTILHVDDSLQAIKLQCIGK
TVE-SQLYTNPDSRYILLPVVLHHLHIHLQEQKDLIMCARILSNVFCLIKKNSSEKSVLE
EIDVIVASLLDILLRTILEITSRPQPSSSAMRFQFQDVTRTGFLNRESLHDSSTLST---
-----FSFCADTYGKLPMTGRHTGEFVACLLSLLRQMTDRHYQQLLDSFNTKEELRDFLL
QIFTV-----FRILIRP-----EMF-PKDWTVMRLVA---NN-VIITTVLYLSDALRKNF
LNENFDYKIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKYG-----DMRVTMGCEIF
SMWQNLGEHKLHFIPALIGPFLEVTLIPQPDLRNVMIPIFHDMM-----

PF06920 // ENSGT00610000085806_3_Domain_5 (1250, 1759)

-DWEQRRSGNF
KQVEAKLIDKLDSLMSEGKGDETYRELFNSIIPLFGP---YPSLLKKIERETWRESGVSL
IATVTRLMERLLDYRDCMKMGEVDGTIHTCTFILQNFYKTELNKEEMYIRYIHKLYDLHL
KAQNFTEAAYTLLLYDELLEWSDRPLREFLTYPMQTEWQRKEHLHLTIIQNFDRGKCWEN
GIILCRKIAEQYESYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLR
NKEFVCRGHDYERLEAFQQRMLNEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPIPES
QEVLQREGVPDNIKSFYKVNHIWKFRYDRPFHKGTKDKENEFKSLWVERTSLYLVQSLPG
ISRWFEVEKREVVEMSPLENAIEVLENKNQQLKTLISQCQTRQMQNINPLTMCLNGVIDA
AVNGGVSRYQEAFFVKEYILSHPEDGEKIARLRELMLEQ---AQILEFGLAVHEKFVPQD
MRPLHKKLVDQFFVMKSSLGIQEFSACMQASPVHFPNGSPRVCRNSAPASVSPDGTRVIP
RR---SPLSYPAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQ--------------
--------PSPSTSSLSSTHSASPNVTSSAPSSARASPLLSDKHKHSRENSCLSPRDRPC
SAIYPTPVEPSQAGL---------------------------------------------
-----------------E-LLTSGDPPLCYSLPAVNPTPSSWSLDSGKEAKNMSDSGKLI
SPPVPPRPTQTASPARHTTSV-SPSPAGRSPLK----------------GSVQSFTPSPV
EYH--SPGLISNSPVLSGSYSSGISSLSRCSTSETSGFENQVNEQSVPLPVPVPV-PVP-
---------I-YGGEEPVRKESKTPPPYSVYERTLRRPVPLPHSLSIPV------TPEPP
ALPPKPLAARSSHLENG-ARRTDPGPRPRPLPRKVSQL-

------------------MWIPTEHEKYGVVIASFRGTVPYGLSLEIGDTVQILEKCDGW
YRGFALKNPNIKGIFPSS--YIHLKNACV

PF16172 // ENSGT00610000085806_3_Domain_1 (90, 451)

KNKGQFEMIIPTEDSVITEMTSTLRDWGAMW
KQLYVRNEGDLFHRLWHIMNEILDLRRQVLVGHLTHDRMKDVKRHITARLDWGNEQLGLD
LVPRKEYAMVDPEDISITELYRL---------------------------------MEHR
HRKKDTPVQASSHHLFVQMKSLMCSNLGEELEVIFSLFDSKENRPISERFFLRLNRNGLP
KAPDKPERHCSLFVDLGSSELRKDIYITVHIIRI---GRMGAGEKKNACSVQYRRPFG--
CAVLSIADLLTGETKDDLILKVYMCNTESEWYQIHENIIKKLNARYNLTGSNAGLAVSLQ
LLHGDIE-QIRREYSSMFSHGVSITRKLGF

ENSGT00610000085806_3_Linker_1_3 (451, 456)

SNIIM

PF14429 // ENSGT00610000085806_3_Domain_3 (456, 652)

PGEMRNDLYITIERGEFEKGGKSVA
RNVEVTMYVVDSSSQTLKDFISFGSGE------PPASEYHSFVLYH--NNSPRWSELLKL
PIPVDKFRGAHIRFEFRHCSTKEK---GEKKLFGFSFVPLMQEDGRTLPDGTHELIVHKC
EENTNLQDTTRYLKLPFSKGI-FLGNNNQAMKATKESFWITSFLCSTKLTQ

ENSGT00610000085806_3_Linker_3_5 (652, 1250)

N---GDMLD
LLKWRTHP----------DKITGCLSKLKEIDGSEIVKFLQDTLDTLFGILDENSQKYGS
KVFDSLVHIINLLQDSKFHHFKPVMDTYIESHFAGA--LAYRDLIKVLKWYVDRITEAER
QEHIQEVLKAQEYIFKYIVQSRRLFSLATGGQNEEEFRCCIQELLMSVRFFLSQESKGSG
ALSQSQAVFLSSFPAVYSELLKLFDVREVANLVQDTLGSLPTILHVDDSLQAIKLQCIGK
TVE-SQLYTNPDSRYILLPVVLHHLHIHLQEQKDLIMCARILSNVFCLIKKNSSEKSVLE
EIDVIVASLLDILLRTILEITSRPQPSSSAMRLQFQDV----------------------
----------------------TGEFVACLLSLLRQMTDRHYQQLLDSFNTKEELRDFLL
QIFTV-----FRILIRPEM------FPKDWTVMRLVA----NNVIITTVLYLSDALRKNF
LNENFDYKIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKYG-----DMRVTMGCEIF
SMWQNLGEHKLHFIPALIGPFLEVTLIPQPDLRNVMIPIFHDMM-----

PF06920 // ENSGT00610000085806_3_Domain_5 (1250, 1759)

-DWEQRRSGNF
KQVEAKLIDKLDSLMSEGKGDETYRELFNSIIPLFGP---YPSLLKKIERETWRESGVSL
IATVTRLMERLLDYRDCMKMGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHL
KAQNFTEAAYTLLLYDELLEWSDRPLREFLTYPMQTEWQRKEHLHLTIIQNFDRGKCWEN
GIILCRKIAEQYESYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLR
NKEFVCRGHDYERLEAFQQRMLNEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPIPES
QEVLQREGVPDNIKSFYKVNHIWKFRYDRPFHKGTKDKENEFKSLWVERTSLYLVQSLPG
ISRWFEVEKREVVEMSPLENAIEVLENKNQQLKTLISQCQTRQMQNINPLTMCLNGVIDA
AVNGGVSRYQEAFFVKEYILSHPEDGEKIARLRELMLEQ---AQILEFGLAVHEKFVPQD
MRPLHKKLVDQFFVMKSSLGIQEFSACIQASPVHFPNGSPRVCRNSAPASMSPDGTRVIP
RR---SPLSYPAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQ--------------
--------PSPSTSSLSSTHSASPNVTSSAPSSARASPLLSDKHKHSRENSCLSPRERPC
SAIYPTPVEPS-------------------------------------------------
-------QRMLFNHIGDG-ALPRSDPNLSAPEKAVNPTPSSWSLDSGKEAKNMSDSGKLI
SPPIPPRPTQTASPARHTTSV-SPSPAGRSPLK----------------GSVQSFTPSPV
EYH--SPGLISNSPVLSGSYSSGISSLSRCSTSETSGFENQVNEPVAPAP----------
--------VSPYGPEEPVRKESKTPPPYSVYERTLRRPXXXXXXXXXXXXX----XXXXX
XXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXX---

------------------VWYYQEIL

PF00018 // ENSGT00610000085806_3_Domain_0 (27, 85)

SFGQVVASFRATSQHGLTLEIGDTVQILEKCEGW
YRGFAVKNPNVKNVYLFPANGVILEVIVLRHHKHTE-CLPYENSLVCPLLGHLSQWHSFW
YNVLSTDKAKRENLRQHCCNLIYMSKRNSLLGTQIQMLLLCMKLLLTLLLFCFHRQLGLD
LVPRKEFAMVDPEEISITELYRLMSCFHSN------------SSIKVTRIILSFDQMEHR
HRKKDTPVPASSHHLFVQMKSLMCSNLGEELEVIFSLYDSKESRPISERFFVRLNKNGLP
KSPEKSERYSSLFIDLSSSDLRKDIFITVHIIRIALVGRMGAGEKKNSSNMQYRRPFG--
CAALSIADLLTGESKDDLVLKVYMCNTESDWYQIHENIIKKLNARYNLTGSNTGLAVSLQ
LLHGDIE-QIRRDYSSVFTRGVSITRKLGFSDVIMPGEMRNDLYITIEKGEYEKGGKSVA
RNVQVSMVILNSEGQILKDYISFGSGE------PPANEYHSFVLYH--NNSPRWAELIKL
PIPVDKFRGAHIRFEFRHCSTKEK---GEKKLFGFCFVPLMQEDGRTFPDGTHELIVHKC
EENTVFQDPCRYLKLSFLKGN-QPGNNNQAVKYTKESFWITSFLCSSKLTQN---GDMLD
LLKWRMHP----------ENIPHCLSKLKEIDGSEIVKFLQDTLDTLFGILNENSPKYGS
KVFDCLVHIINLLQDSKFQHFKPVMDTYIEAHFSGA--LAYRDLIKVLKWYVDRIIEAER
QEHIQDVLKAQEYIFKYIVQSRKLFSLTTGGQNEEEFRCCIQELLMSIRFFLSQESKGTS
ALSQSQAVFLNSFPTVYSELLKLFDVREVANLVRDTLGSLPTIMHADDSLQDVKLQCIAK
TVE-SELYSNPESRFILLPVVMHHLHMHLQEQKDLGMCARILSNMFHLSKKSNSEKTAMK
EIDVIVNSLLDILLRTILEITSRPQPSGSAMRLQFQDVTNSLCGAGITLM----------
-----------------LH------------KKTRVLKDLRRQHVKCNSYPQTHLQDFLL
QIFTV-----FRILIRPE------MFPKDWTVMRFVAN----NVIITTVLYLSDALRKNF
LNDSFDYKIWDSYFYLAVIFINQSCLQLEMFTPSKMKKVLEKYG-----DMRVTMGCEIF
SMWQNLGEHKLHFIPALIGPFLEVTLIPQPDLRNVMIPIFHDMM------DWEQRRSGNF
KQVEAKLIDKLDSLMSEGKGDETYRELFNSIIPLFGP---YPSLLKKIERETWRESGVSL
IATVTRLMERLLDYRDCMKMGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHM
KAQNFTEGAYTLLLYDELLEWSDRPLREFISYPMQTEWQRKEYLHMTIIQNFDRGKCWEN
GIILCRKLAEQYESYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLR
NKEFVCRGHDYERLEAFQQRMLTEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPIPET
QEVLQRDGIPDNI

PF06920 // ENSGT00610000085806_3_Domain_5 (1574, 1761)

KSFYKVNHIWRFRYDRPFHKGTKDKENEFKSLWVERTALTLVQSLPG
ISRWFEVEKREVVEMSPLENAIEVLENKNQQLRTLISQCQARQMQNINPLTMCLNGVIDA
AVNGGVSRYQEAFFVKEYIFNHPEDGDKITRLRELMLEQ---AQILEFGLAVHEKFVPQD
MRPLHKKMVDQFFVMKSSLGIQDFSTCVPPSPINFLNGSPRIPRNSAPAIMGPDAARVVP
RR---SPLSYPAVNRYSSSSLSSQASAEVSNLTGQSESSDEVFHMQITFPNCLICFKLTA
VGFVCPCPPSPSTSSLSSTHSASPNVTSSAPSSARASPLLSDKHKHSRETSCLSPRERPC
SAIFPIPAEPPQ------------------------------------------------
------FRRVLFNHIGET-TLPRSDPNLSAPEKG--------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------

------------------------------------------------------------
------------------------------------MVIPTEDSVITEMTSTLRDWGTMW
KQLYVRNEGDLFHRLWHIMNEILDLRRQVLVGHLTHDRMKDVKRHITARLDWGNEQLGLD
LVPRKEYAMVDPEDISITELYRL---------------------------------MEHR
HRKKDTPVQASSHHLFVQMKSLMCSNLGEELEVIFSLFDSKENRPISERFFLRLNRNGLP
KAPDKPERHCSLFVDLGSSELRKDIYITVHIIRI---GRMGAGEKKNACSVQYRRPFG--
CAVLSIADLLTGETKDDLILKVYMCNTESEWYQIHENIIKKLNARYNLTGSNAGLAVSLQ
LLHGDIE-QIRREYSSVFSHGVSITRKLGFSNIIMPGEMRNDLYITIERGEFEKGGKSVA
RNVEVTMFIVDSSGQTLKDFISFGSGE------PPASEYHSFVLYH--NNSPRWSELLKL
PIPVDKFRGAHIRFEFRHCSTKEK---GEKKLFGFSFVPLMQEDGRTLPDGTHELIVHKC
EENTNLQDTTRYLKLPFSKGI-FLGNNNQAMKATKESFCITSFLCSTKLTQN---GDMLD
LLKWRTHP----------DKITGCLSKLKEIDGSEIVKFLQDTLDTLFGILDENSQKYGS
KVFDSLVHIINLLQDSKFHHFKPVMDTYIESHFAGA--LAYRDLIKVLKWYVDRITEAER
QEHIQEVLKAQEYIFKYIVQSRRLFSLATGGQNEEEFRCCIQELLMSVRFFLSQESKGSG
ALSQSQAVFLSSFPAVYSELLKLFDVREVANLVQDTLGSLPTILHVDDSLQAIKLQCIGK
TVE-SQLYTNPDSRYILLPVVLHHLHIHLQEQKDLIMCARILSNVFCLIKKNSSEKSVLE
EIDVIVASLLDILLRTILEITSRPQPSSSAMRFQFQDV----------------------
----------------------TGEFVACLLSLLRQMTDRHYQQLLDSFNTKEELRDFLL
QIFTV-----FRILIRP-----EMF-PKDWTVMRLVA---NN-VIITTVLYLSDALRKNF
LNENFDYKIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKYG-----DMRVTMGCEIF
SMWQNLGEHKLHFIPALIGPFLEVTLIPQPDLRNVMIPIFHDMM------DWEQRRSGNF
KQVEAKLIDKLDSLMSEGKGDETYRELFNSI------------LLKKIERETWRESGVSL
IATVTRLMERLLDYRDCMKMGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHL
KAQNFTEAAYTLLLYDELLEWSDRPLREFLTYPMQTEWQRKEHLHLTIIQNFDRGKCWEN
GIILCRKIAEQYESYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLR
NKEFVCRGHDYERLEAFQQRMLNEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPIPES
QEVLQREGVPDNIK

PF06920 // ENSGT00610000085806_3_Domain_5 (1575, 1759)

SFYKVNHIWKFRYDRPFHKGTKDKENEFKSLWVERTSLYLVQSLPG
ISRWFEVEKREVVEMSPLENAIEVLENKNQQLKTLISQCQTRQMQNINPLTMCLNGVIDA
AVNGGVSRYQEAFFVKEYILSHPEDGEKIARLRELMLEQ---AQILEFGLAVHEKFVPQD
MRPLHKKLVDQFFVMKSSLGIQEFSACMQASPVHFPNGSPRVCRNSAPASVSPDGTRVIP
RR---SPLSYPAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQ--------------
--------PSPSTSSLSSTHSASPNVTSSAPSSARASPLLSDKHKHSRENSCLSPRERPC
SAIYPTPVEPS-------------------------------------------------
-------QRMLFNHIGDG-ALPRSDPNLSAPEKAVNPTPSSWSLDSGKEAKNMSDSGKLI
SPPVPPRPTQTASPARHTTSV-SPSPAGRSPLK----------------GSVQSFTPSPV
EYH--SPGLISNSPVLSGSYSSGISSLSRCSTSETSGFENQVNEQSVPLPVPV-----PV
--PVPVPVPS-YGGEEPVRKESKTPPPYSVYERTLRRPVPLPHSLSIPV------TPEPP
ALPPKPLAARSSHLENG-ARRTDPGPRPRPLPRKVSQL-

------------------MIISIYSVSFLTVIASFRGTVPYGLSLEIGDTVQILEKCDGW
YRGFALKNPNIKGIFPSS--YVHLKNACVKNKGQFEMVIPTEDSVITEMTSTLRDWGTMW
KQLYVRNEGDLFHRLWHIMNEILDLRRQVLVGHLTHDRMKDVKRHITARLDWGNEQLGLD
LVPRKEYAMVDPEDISITELYRL---------------------------------MEHR
HRKKDTPVQASSHHLFVQMKSLMCSNLGEELEVIFSLFDSKENRPISERFFLRLNRNGLP
KAPDKPERHCSLFVDLGSSELRKDIYITVHIIRI---GRMGAGEKKNACSVQYRRPFG--
CAVLSIADLLTGETKDDLILKVYMCNTESEWYQIHENIIKKLNARYNLTGSNAGLAVSLQ
LLHGDIE-QIRREYSSVFSHGVSITRKLGFSNIIMPGEMRNDLYITIERGEFEKGGKSVA
RNVEVTMFIVESSGQTLKDFISFGSGE------PPASEYHSFVLYH--NNSPRWSELLKL
PIPVDKFRGAHIRFEFRHCSTKEK---GEKKLFGFSFVPLMQEDGRTLPDGTHELIVHKC
EENTNLQDTTRYLKLPFSKGI-LLGNNNQAMKATKESFWITSFLCSTKLTQN---GDMLD
LLKWRTHP----------DKITGCLSKLKEIDGSEIVKFLQDTLDTLFGILDENSQKYGS
KVFDSLVHIINLLQDSKFHHFKPVMDTYIESHFAGA--LAYRDLIKVLKWYVDRITEAER
QEHIQEVLKAQEYIFKYIVQSRRLFSLATGGQNEEEFRCCIQELLMSVRFFLSQESKGSG
ALSQSQAVFLSSFPAVYSELLKLFDVREVANLVQDTLGSLPTIVHVDDALQAVKLQCIGK
TVE-SQLYTNPDSRYILLPVVLHHLHMHLQEQKDLIMCARILSNVFCLIKKNSSEKSVLE
EIDVIVASLLDILLRTILEITSRPQPSGSTMRLQFQDV----------------------
----------------------TGEFVACLLSLLRQMTDRHYQQLLDSFNTKEELRDFLL
QIFTV-----FRILIRPEM------FPKDWTVMRLVA----NNVIITTVLYLSDALRKNF
LNENFDYKIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKYG-----DMRVTMGCEIF
SMWQNLGEHKLHFIPALIGPFLEVTLIPQPDLRNVMIPIFHDMM------DWEQRRSGNF
KQVEAKLIDKLDSLMSEGKGDETYRELFNSIIPLFG---PYPSLLKKIERETWRESGVSL
IATVTRLMERLLDYRDCMKMGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHV
KAQNFTEAAYTLLLYDELLEWSDRPLREFLTYPMQTEWQRKEHLHLAIIQNFDRGKCWEN
GIILCRKIAEQYESYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLR
NKEFVCRGHDYERLEAFQQRMLNEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPIPES
QEVLQREGVPDNIK

PF06920 // ENSGT00610000085806_3_Domain_5 (1575, 1759)

SFYKVNHIWKFRYDRPFHKGTKDKENEFKSLWVERTSLYLVQSLPG
ISRWFEVEKREVVEMSPLENAIEVLENKNQQLKTLISQCQTRQMQNINPLTMCLNGVIDA
AVNGGVSRYQEAFFVKEYILSHPEDGEKIARLRELMLEQ---AQILEFGLAVHEKFVPQD
MRPLHKKLVDQFFVMKSSLGIQEFSACIQASPVHFPNGSPRVCRNSAPASMSPDGTRVIP
RR---SPLSYPAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQ--------------
--------PSPSTSSLSSTHSASPNVTSSAPSSARASPLLSDKHKHSRENSCLSPRERPC
SAIYPTPVEPS-------------------------------------------------
-------QRLLFNHIGDG-ALPRSDPNLSAPEKAVNPTPSSWSLDSGKEAKNMADGGKLI
SPPVPPRPTQTASPARHTASV-SPSPAGRSPLK----------------GSVQSFTPSPV
EYH--SPGLISNSPVLSGSYSSGISSLSRCSTSETSGFENQVNEPSAAPLGSG-------
-------PGYGGGSEEPVRKESKTPPPYSVYERTLRRPVPLPHSLSIPV------TAEPP
ALPPKPLAARSGHLENG-TRRTDPGPRPRPLPRKVSQL-

------------------MWIPTEHEKYGVVIASFRGTIPHGLSLEIGDTVQILEKCDHW
YRGFALKNPNIKGTFPSN--YIHLKNACVKNKGQFEMVIPTEDSVITEMTSTLRDWGTMW
KQLYVRNEGDLFHRLWHIMNEILDLRRQVLVGHLTHDRMKDVKRHITARLDWGNEQLGLD
LVPRKEYAMVDPEEISITELYRL---------------------------------MEHR
HRKKDTPVPASSHHLFVQMKSLMCSNLGEELEVIFSLFDSKENRPISERFFLRLNRNGLP
KCPEKPERHCSLFVDLSSSELRKDIYITVHIIRI---GRMGAGEKKNACNVQYRRPFG--
CAVLSIADLLAGDAKDDLILKVYMCNTESDWYQIHENIIKKLNVRYNLTGSNAGLAVSLQ
LFHGDIE-QIRRDYTSMFTHGVSITRKLGFSNIIMPGEMRNDLYITIERGEFEKGGKSVA
RNVEVMMYIVDNGGQILKDFISFGSGE------PPASKFHSFVLYH--NNSPRWAELLKL
PIPVDKFRGAHIRFEFRHCSTKEK---GEKKLFGFSFVPLMQENGRTLPDGTHELIVHKC
EENTYLQDSSHYLKLPFSKGI-LLGNNNQAIKNTKESFWITSFLCSTKLTQN---GDMLD
LLKWRAHP----------DKIAGCLTKLKEIDGSEIVKFLQDTLDTLFGILDENSQKYGS
KVFDSLVHIINLLQDSKFQHFKPVMDTYIESHFAGA--LAYRDLIKVLKWHVDRVTDMEV
QEHIHDVLKALEYIFKYIVQSRRLFSLATGGQNEEEFRCCIQELLMSIRFFLSQESKGAS
ALSQSQAVFLSSFPAVYSELLKLFDVREVANLVHDTLGSLPTIMHVDESLQAVKLQCIGK
TVE-SQLYTNPDSRYILLPVVLHHLHMHLQEQKDLTMCARILSNIFCFIKKNSSEKSVLE
EIDVIVNSLLDILLRTILEITSRPQPSGSAMRLQFQDV----------------------
----------------------TGEFVSCLLSLLRQMTDRHYQQLLDRFNTKDELRDFLL
QIFTV-----FRILIRP-----EMF-PKDWTVMRLVA---NN-VIITTVLYLSDALRKNF
LNENFDYKIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKYG-----DMRVTMGCEIF
SMWQNLGEHKLHFIPALIGPFLEVTLIPQPDLRNVMIPIFHDMM------DWEQRRSGNF
KQVEAKLIDKLDSLMSEGKGDETYRELFNSI------------LLKKIERETWRESGVSL
IATVTRLMERLLDYRDCMKMGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHL
KAQNFTEAAYTLLLYDELLEWSDRPLREFLNYPMQTEWQRKEYLHLTIIQNFDRGKCWEN
GIILCRKIAEQYESYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLR
NKEFVCRGHDYERLEAFQQRMLNEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPIPES
QEVLQREGIPDNIK

PF06920 // ENSGT00610000085806_3_Domain_5 (1575, 1759)

SFYKVNHIWRFRYDRPFHKGTKDKENEFKSLWVERTTLILVQSLPG
ISRWFEVEKREVVEMSPLENAIEVLENKNQQLRTLISQCQTRQMQNINPLTMCLNGVIDA
AVNGGVARYQEAFFVKEYILNHPQDGEKITRLRELMLEQ---AQILEFGLAVHEKFVPQD
MRPLHKKLVDQFFVMKSSLGIQEFSACVQASPVHFPNGSPRVCRNSAPASMSPEGARVIP
RR---SPLSYPAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQ--------------
--------PSPSTSSLSSTHSASPNVTSSAPSSARASPLLSDKHKHSRENSCLSPRERPC
SAIYPIPSEPSQPANSCFAKWNAASVSRCTRDSPREREEPLGPISTLPEAHLTGKPPNLS
LPSMPPDRRMLLNNFGDG-ALPRSDPNLSGPEKAVNPTPSSWSLDSGKEARNMSESGKLM
SPPVPPRPTQTASPARHVALV-SPSSAGRSPMK----------------GSVQSFTPSPV
ECH--SSGLISNSPVLSGSYSSGISSLSRCSTSETSGFESQGNEQ-----------TIP-
--------NY-SVSEEPMRKESKTPPPYSVYERTLRRPVPLPHSLSIPV------TSDPP
ALPPKPLQARPNNLENS-SRRTEQVPRPRPLPRKVSQL-

------------------MWIPTEHEK

PF07653 // ENSGT00610000085806_3_Domain_0 (28, 82)

YGVVIASFRGTVPYGLSLEIGDTVQILEKCDGW
YRGFALKNPNIKGIFPSS--Y

ENSGT00610000085806_3_Linker_0_1 (82, 90)

VHLKNACV

PF16172 // ENSGT00610000085806_3_Domain_1 (90, 451)

KNKGQFEMVIPTEDSVITEMTSTLRDWGTMW
KQLYVRNEGDLFHRLWHIMNEILDLRRQVLVGHLTHDRMKDVKRHITARLDWGNEQLGLD
LVPRKEYAMVDPEDISITELYRL---------------------------------MEHR
HRKKDTPVQASSHHLFVQMKSLMCSNLGEELEVIFSLFDSKENRPISERFFLRLNRNGLP
KAPDKPERHCSLFVDLGSSELRKDIYITVHIIRI---GRMGAGEKKNACSVQYRRPFG--
CAVLSIADLLTGETKDDLILKVYMCNTESEWYQIHENIIKKLNARYNLTGSNAGLAVSLQ
LLHGDIE-QIRREYSSVFSHGVSITRKLGF

ENSGT00610000085806_3_Linker_1_3 (451, 456)

SNIIM

PF14429 // ENSGT00610000085806_3_Domain_3 (456, 652)

PGEMRNDLYITIERGEFEKGGKSVA
RNVEVTMFIVDSSGQTLKDFISFGSGE------PPASEYHSFVLYH--NNSPRWSELLKL
PIPVDKFRGAHIRFEFRHCSTKEK---GEKKLFGFSFVPLMQEDGRTLPDGTHELIVHKC
EENTNLQDTTRYLKLPFSKGI-FLGNNNQAMKATKESFCITSFLCSTKLTQ

ENSGT00610000085806_3_Linker_3_5 (652, 1250)

N---GDMLD
LLKWRTHP----------DKITGCLSKLKEIDGSEIVKFLQDTLDTLFGILDENSQKYGS
KVFDSLVHIINLLQDSKFHHFKPVMDTYIESHFAGA--LAYRDLIKVLKWYVDRITEAER
QEHIQEVLKAQEYIFKYIVQSRRLFSLATGGQNEEEFRCCIQELLMSVRFFLSQESKGSG
ALSQSQAVFLSSFPAVYSELLKLFDVREVANLVQDTLGSLPTILHVDDSLQAIKLQCIGK
TVE-SQLYTNPDSRYILLPVVLHHLHIHLQEQKDLIMCARILSNVFCLIKKNSSEKSVLE
EIDVIVASLLDILLRTILEITSRPQPSSSAMRFQFQDV----------------------
----------------------TGEFVACLLSLLRQMTDRHYQQLLDSFNTKEELRDFLL
QIFTV-----FRILIRP-----EMF-PKDWTVMRLVA---NN-VIITTVLYLSDALRKNF
LNENFDYKIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKYG-----DMRVTMGCEIF
SMWQNLGEHKLHFIPALIGPFLEVTLIPQPDLRNVMIPIFHDMM-----

PF06920 // ENSGT00610000085806_3_Domain_5 (1250, 1759)

-DWEQRRSGNF
KQVEAKLIDKLDSLMSEGKGDETYRELFNSI------------LLKKIERETWRESGVSL
IATVTRLMERLLDYRDCMKMGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHL
KAQNFTEAAYTLLLYDELLEWSDRPLREFLTYPMQTEWQRKEHLHLTIIQNFDRGKCWEN
GIILCRKIAEQYESYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLR
NKEFVCRGHDYERLEAFQQRMLNEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPIPES
QEVLQREGVPDNIKSFYKVNHIWKFRYDRPFHKGTKDKENEFKSLWVERTSLYLVQSLPG
ISRWFEVEKREVVEMSPLENAIEVLENKNQQLKTLISQCQTRQMQNINPLTMCLNGVIDA
AVNGGVSRYQEAFFVKEYILSHPEDGEKIARLRELMLEQ---AQILEFGLAVHEKFVPQD
MRPLHKKLVDQFFVMKSSLGIQEFSACMQASPVHFPNGSPRVCRNSAPASVSPDGTRVIP
RR---SPLSYPAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQ--------------
--------PSPSTSSLSSTHSASPNVTSSAPSSARASPLLSDKHKHSRENSCLSPRERPC
SAIYPTPVEPS-------------------------------------------------
-------QRMLFNHIGDG-ALPRSDPNLSAPEKAVNPTPSSWSLDSGKEAKNMSDSGKLI
SPPVPPRPTQTASPARHTTSV-SPSPAGRSPLK----------------GSVQSFTPSPV
EYH--SPGLISNSPVLSGSYSSGISSLSRCSTSETSGFENQVNEQSAPLPVP--------
---VPVPVPS-YGGEEPVRKESKTPPPYSVYERTLRRPVPLPHSLSIPV------TSEPP
ALPPKPLAARSSHLENG-ARRTDPGPRPRPLPRKVSQL-

--------------------------AEQHVIASFRGTVPYGLSLEIGDTVQILEKCDGW
YRGFALKNPNIKGIFPSS--YVHLKNACV

PF16172 // ENSGT00610000085806_3_Domain_1 (90, 451)

KNKGQFEMVIPTEDSVITEMTSTLRDWGAMW
KQLYVRNEGDLFHRLWHIMNEILDLRRQVLVGHLTHDRMKDVKRHITARLDWGNEQLGLD
LVPRKEYSMVDPEDISITELYRL---------------------------------MEHR
HRKKDTPVQASSHHLFVQMKSLMCSNLGEELEVIFSLFDSKENRPISERFFLRLNRNGLP
KAPDKPERHCSLFMDLGSSELRKDIYITVHIIRI---GRMGAGEKKNACSVQYRRPFG--
CAVLSIADLLTGETKDDLVLKVYMCNTESEWYQIHENIIKKLNARYNLTGSNAGLAVSLQ
LLHGDVE-QIRREYSSVFSHGVSMTRKLGF

ENSGT00610000085806_3_Linker_1_3 (451, 456)

SNIIM

PF14429 // ENSGT00610000085806_3_Domain_3 (456, 652)

PGEMRNDLYITIERGEFEKGGKSVA
RNVEVTMFIVDSSGQTLKDFISFGSGE------PPACEYHSFVLYH--NNSPRWSELLKL
PIPVDKFRGAHIRFEFRHCSTKEK---GEKKLFGFSFVPLMQEDGRTLPDGTHELIVHKC
EENTNLQDTTRYLKLPFSKGI-FLGNNNQAMKATKESFWITSFLCSTKLTQ

ENSGT00610000085806_3_Linker_3_5 (652, 1250)

N---GDMLD
LLKWRTHP----------DKITGCLSKLKEIDGSEIVKFLQDTLDTLFGILDENSQKYGS
KVFDSLVHIINLLQDSKFHHFKPVMDTYIESHFAGA--LAHRDLIKVLKWYVDRITEAER
QEHIQEVLKAQEYIFKYIVQSRRLFSLATGGQNEEEFRCCIQELLMSVRFFLSQESKGSG
ALSQSQAVFLSSFPAVYSELLKLFDVREVANLVQDTLGSLPTVMHVDDSLQAIKLQCIGK
TVE-SQLYTNPDSRYILLPVVLHHLHIHLLEQKDLIVCARILSNVFCLIKKNSSEKSVLE
EIDVIVASLLDILLRTILEITSRPQPSSSAMRLQFQDV----------------------
----------------------TGEFVACLLSLLRQMTDRHYQQLLDSFNTKEELRDFLL
QIFTV-----FRILIRP-----EMF-PKDWTVMRLVA----NNVIITTILYLSDALRKNF
LNENFDYKIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKYG-----DMRVTMGCEIF
SMWQNLGEHKLHFIPALIGPFLEVTLIPQPDLRNVMIPIFHDMM-----

PF06920 // ENSGT00610000085806_3_Domain_5 (1250, 1759)

-DWEQRRSGSF
KQVEAKLIDKLDSLMSEGKGDETYRELFNSIIPLFGP---YPSLLKKIERETWRESGVSL
IATVTRLMERLLDYRDCMKMGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHL
KAQNFTEAAYTLLLYDELLEWSDRPLREFLTYPMQTEWQRKEHLHLTIIQNFDRGKCWEN
GIILCRKIAEQYESYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLR
NKEFVCRGHDYERLEAFQQRMLTEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPMPES
QEVLQREGVPDNIKSFYKVNHIWKFRYDRPFHKGTKDKENEFKSLWVERTSLYLVQSLPG
ISRWFEVEKREVVEMSPLENAIEVLENKNQQLKTLISQCQTRQMQNINPLTMCLNGVIDA
AVNGGVSRYQEAFFVKEYILSHPEDGEKIARLRELMLEQ---AQILEFGLAVHEKFVPQD
MRPLHKKLVDQFFVMKSSLGIQEFSTCIQASPVHFPNGSPRVCRNSAPASMSPDGTRVIP
RR---SPLSYPAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQ--------------
--------PPRTGFIFRDCAN-CHNV-PSSFFLFSASPLLSDKHKHSRENSCLSPRERPC
SAIYPTPGEPS-------------------------------------------------
-------QRMLFNHIGDG-ASPRSDPNLSAPEKAVNPTPSSWSLDSGKEAKNMSDSGKLI
SPPVPPRPTQTASPARHTTAV-SPSPAGRSPLK------------------VQGFTPSPV
EYH--CPGLTSNSPVLSGSYSSGISSLSRCSMSETSGFESQMNEQPAP------------
------------------------------------------------------------
---------------NG-TRRTEPGPRPRPLPRKVSQL-

------------------------------VIASFRGAVPHGLSLEIGDTVQILEKCDGW
YRGFALKNPNLKGIFPSS--YIHLKNACVKNKGMLDVSVQTESSRVRAIGAVLKRGAASW
YVQLHA-------------------RRDPCLGHTVWFLFLKMMFMLK------HQ-----
-------------NMSDVKRYITKICIMCNENSRRSFVNKTFHDMIVPLKLSIYHLMEHR
HRKKDTPIPASSHHLFVQMKSLMCSNLGEELEVIFSLFDSKENRPISERFFLRLNRNGLP
KCPEKPERHCSLFVDLGSSELRKDIYITVHIIRI---GRMGAGEKKNSCNVQYRRPFG--
CAVLSIADLLAGDTKDDLVLKVYMCNTESDWYQIHENIIKKLNARYNLTGSNAGLAVSLQ
LLHGDIE-QIRRDYTSMFTHGVSITRKLGFSNIIMPGEMRNDLYITIERGEFEKGGKSVA
RNVEVTMYIVDCGGQILKDFISFGSGE------PPATEFHSFVLYH--NNSPRWAELLKL
PIPVDKFRGAHLRFEFRHCSTKEK---GEKKLFGFSFVPLMQENGRTLPDGTHELIVHKC
EENVSLQDSSRYLKFPFSKGH-LLTNNHQVVKTTKESFWITSFLCSTKLTQN---GDMLD
LLKWRAHP----------EKIAGCLSKLKEIDGSEIVKFLQDTLDTLFGILDENSQKYGS
QVFDCLVHIINLLQDSKFHHFKPVMDTYIESHFAGA--LAYRDLIKVLKWHVDRITELER
QTHNQEVLKAQEYIFKYIVQSRKLFSLATGGQNEEEFCCCIQELLMSVRFFLSQETKGTS
ALSQAQVVFLNSFPAVYSELLKLFDVREVANLVRDTLGSLPTITNSDESLQAVKLQCIGK
TVE-SELYTNPESRYILLPVVLHHLYVHLQEQKDLIMCARILSNIFCFIKKNSSEKSILE
EIDVIVNSLLDVLLRTILEITSRPQPAGTATRLQFQDV----------------------
----------------------TGEFVSCLLSLLRQMTDRHYQQLLDRFKTKDELRDFLL
QIFTV-----FRILIRPE------MFPKDWTVMRLVAN----NVIITTVLYLSDALRKNF
LNESFDYKIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKYG-----DMRVTMGCEIF
SMWQNLGEHKVHFIPALIGPFLEVTLIPQSDLRNVMIPIFHDMM------DWEQRRSGNF
KQVEAKLIDKLDSLMSEGKGDETYRELFNSIIPLFGP---YPSLLKKIERETWRESGVSL
IATVTRLMERLLDYRDCMKMGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHL
KAQNFTEAAYTLLLYDELLEWSDRPLREFLNYPMQTEWQRKEYLHLTIIQNFDRGKCWEN
GIILCRKIAEQYESYYDYRNLSKMRVMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLR
NKEFVCRGHDYERLEAFQQRMLNEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPIPES
QEVLQREGIPDNIK

PF06920 // ENSGT00610000085806_3_Domain_5 (1575, 1759)

SFYKVNHIWRFRYDRPFHKGTKDKDNEFKSLWVERTTLILVQSLPG
ISRWFEVEKREVVEMSPLENAIEVLENKNQQLRTLISQCQTRQMQNINPLTMCLNGVIDA
AVNGGVARYQEAFFVKEYVLTHPEDGEKIACLRELMLEQCIKAQILEFGLAVHEKFVPQD
MRPLHKKLVDQFFVMKSSLGIQEFAACIQSSPVHFPNGSPRVSRNSMPVSMSPEGARVIP
RR---SPLSYPAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQ--------------
--------PSPSTSSLSSTHSASPNVTSSAPSSARGSPLLSDKLKHSRENSCLSPRDRPC
SAIYSNAAEPS-------------------------------------------------
-------QRILYNHIGDG-ALPRSDPNLSGPEKAVNSTPSSWSLDSGKEARNMSDCGKLM
SPPVPPRPTQTASPARHL-TSVSPSPAGRSPMKNCGQS--------------FTPS--PV
DYH--SSGLISNSPVLSGSYSSGISSLSRCSTSETSGFESHIIDHSIPV-----------
--------SNCNISEEPVRKESKTPPPYSVYERTLKRPVPLPHSLTIPI------PTDPP
ALPPKPLLVRPNNLENS-NKRTEQVPRPRPLPRKVSQL-

-------------SPFITEHILTNYFRPDTVIASFRGTVPYGLSLEIGDTVQILEKCDGW
YRGFALKNPNIKGIFPSS--YVHLKNACV

PF16172 // ENSGT00610000085806_3_Domain_1 (90, 451)

KNKGQFEMVIPTEDSVITEMTSTLRDWGTMW
KQLYVRNEGDLFHRLWHIMNEILDLRRQVLVGHLTHDRMKDVKRHITARLDWGNEQLGLD
LVPRKEYAMVDPEDISITELYRL---------------------------------MEHR
HRKKDTPVQASSHHLFVQMKSLMCSNLGEELEVIFSLFDSKENRPISERFFLRLNRNGLP
KAPEKPERHCSLFMDLGSSELRKDIYITVHIIRI---GRMGAGEKKNACSVQYRRPFG--
CAVLSIADLLTGETKDDLVLKVYMCNTESEWYQIHENIIKKLNARYNLTGSNAGLAVSLQ
LLHGDIE-QIRREYSSVFSHGVSITRKLGF

ENSGT00610000085806_3_Linker_1_3 (451, 456)

SNIIM

PF14429 // ENSGT00610000085806_3_Domain_3 (456, 652)

PGEMRNDLYITIERGEFEKGGKSVA
RNVEVTMFIVDSSGQTLKDFISFGSGE------PPASEYHSFVLYH--NNSPRWSELLKL
PIPVDKFRGAHIRFEFRHCSTKEK---GEKKLFGFSFVPLMQEDGRTLPDGTHELIVHKC
EENTNLQDTTRYLKLPFSKGI-FLGNNNQAMKTTKESFWITSFLCSTKLTQ

ENSGT00610000085806_3_Linker_3_5 (652, 1250)

N---GDMLD
LLKWRTHP----------DKITGCLSKLKEIDGSEIVKFLQDTLDTLFGILDENSQKYGS
KVFDSLVHIINLLQDSKFHHFKPVMDTYIESHFAGA--LAYRDLIKVLKWYVDRITEAER
QEHIQEVLKAQEYIFKYIVQSRRLFSLATGGQNEEEFRCCIQELLMSVRFFLSQESKGSG
ALSQSQAVFLSSFPAVYSELLKLFDVREVANLVQDTLGSLPTIMHVDDSLQAIKLQCIGK
TVE-SQLYTNPDSRYILLPVVLHHLHIHLQEQKDLIMCARILSNVFCLIKKNSSEKSVLE
EIDVIVASLLDILLRTILEITSRPQPSSSALRLQFQDV----------------------
----------------------TGEFVACLLSLLRQMTDRHYQQLLDSFNTKEELRDFLL
QIFTV-----FRILIRP-----EMF-PKDWTVMRLVA---NN-VIITTVLYLSDALRKNF
LNENFDYKIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKYG-----DMRVTMGCEIF
SMWQNLGEHKLHFIPALIGPFLEVTLIPQPDLRNVMIPIFHDMM-----

PF06920 // ENSGT00610000085806_3_Domain_5 (1250, 1759)

-DWEQRRSGNF
KQVEAKLIDKLDSLMSEGKGDETYRELFNSIIPLFGP---YPSLLKKIERETWRESGVSL
IATVTRLMERLLDYRDCMKMGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHL
KAQNFTEAAYTLLLYDELLEWSDRPLREFLTYPMQTEWQRKEHLHLTIIQNFDRGKCWEN
GIILCRKIAEQYESYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLR
NKEFVCRGHDYERLEAFQQRMLTEFPHAIAMQHANQPDETIFQAE-----IYAVTPIPES
QEVLQREGVPDNIKSFYKVNHIWKFRYDRPFHKGTKDKENEFKSLWVERTSLYLVQSLPG
ISRWFEVEKREVVEMSPLENAIEVLENKNQQLKTLISQCQTRQMQNINPLTMCLNGVIDA
AVNGGVSRYQEAFFVKEYILSHPEDGEKIARLRELMLEQ---AQILEFSLAVHEKFVPQD
MRPLHKKLVDQFFVMKSSLGIQEFSACIQASPVHFPNGSPRVCRNSAPASMSPDGSRVIP
RR---SPLSYPAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQ--------------
--------PSPSTSSLSSTHSASPNVTSSAPSSARASPLLSDKHKHSRENSCLSPRERPC
SAIYPTPGEPS-------------------------------------------------
-------QRMLFNHIGDG-ALPRSDPNLSAPDKAVNPTPSSWSLDSGKEAKNMSDSGKLI
SPPVPPRPTQTAPGGTA------------------------WGLRGGCQGSVQSFTPSPV
EYH--PPGLTSNSPVLSGSYSSGISSLSRCSMSETSGFENQANEPAAP------------
--------GY-SGPEEPARRESKTPPPYSVFERSLRRPAPLPHSLSIPVSQL--------
---------------------------------------

------------------------------

PF07653 // ENSGT00610000085806_3_Domain_0 (31, 84)

VIASFRGTVPYGLSLEIGDTVQILEKCDGW
YRGFALKNPNIKGIFPSS--YVHLKNACVKNKGQFEMVIPTEDSVITEMTSTLRDWGTMW
KQLYVRNEGDLFHRLWHIMNEILDLRRQVLVGHLTHDRMKDVKRHITARLDWGNEQLGLD
LVPRKEYAMVDPEDISITELYRL---------------------------------MEHR
HRKKDTPVQASSHHLFVQMKSLMCSNLGEELEVIFSLFDSKENRPISERFFLRLNRNGLP
KAPDKPERQCSLFVDLGSSELRRDIYITVHIIRI---GRMGAGEKKNACSVQYRRPFG--
CAVLSIADLLTGETKDDLILKVYMCNTESEWYQIHENIIKKLNARYNLTGSNAGLAVSLQ
LLHGDIE-QIRREYSSVFSHGVSITRKLGFSNIIMPGEMRNDLYITIERGEFEKGGKSVA
RNVEVTMFIVESSGQTLKDFISFGSGE------PPASEYHSFVLYH--NNSPRWSELLKL
PIPVDKFRGAHIRFEFRHCSTKEK---GEKKLFGFSFVPLMQEDGRTLPDGTHELIVHKC
EENTNLQDTTRYLKLPFSKGI-LLGNNNQAMKATKESFWITSFLCSTKLTQN---GDMLD
LLKWRTHP----------DKITGCLSKLKEIDGSEIVKFLQDTLDTLFGILDENSQKYGS
KVFDSLVHIINLLQDSKFHHFKPVMDTYIESHFAGA--LAYRDLIKVLKWYVDRITEAER
QEHIQEVLKAQEYIFKYIVQSRRLFSLATGGQNEEEFRRCIQELLMSVRFFLSQESKGSG
ALSQSQAVFLSSFPAVYSELLKLFDVREVANLVQDTLGSLPTIVHVDDALQAVKLQCISK
TVE-SQLYTNPDSRYILLPVVLHHLHMHLQEQKDLIMCARILSNVFCLIKKNSSEKSVLE
EIDLIVASLLDILLRTILEITSRPQPSGSTMRLQFQDV----------------------
----------------------TGEFVACLLSLLRQMTDRHYQQLLDSFNTKEELRDFLL
QIFTV-----FRILIRP-----EMF-PKDWTVMRLVA---NX-XXXXXXXXXXXXXXXXX
XXXXXXXXIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKYG-----DMRVTMGCEIF
SMWQNLXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXIFHDMM------DWEQRRSGNF
IQVEAKLIDKLDSLMSEGKGDETYRELFNSIIPLFGP---YPSLLKXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXDCMKMGEVDGKKIGCTVSLLNFYKTELNKEEMYIRY-HKLYDLHV
KAQNFTEAAYTLLLYDELLEWSDRPLREFLTYPMQTEWQRKEHLHLAIIQNFDRGKCWEN
GIILCRKIAEQYESYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLR
NKEFVCRGHDYERLEAFQQRMLNEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPIPDS
QEVLQREGVPDNIKSFYKVNHIWKFRYDRPFHKGTKDKENEFKSLWVERTSLYLVQSLPG
ISRWFEVEKREVVEMSPLENATEVLENKNQQLKTLISQCQTRQMQNINPLTMCLNGVIDA
AVNGGVSRYQEAFFVKEYILSHPEDGEKIARLRELMLEQ---AQILEFGLAVHEKFVPQD
MRPLHKKLVDQFFVMKSSLGIQEFSACIQASPVHFPNGSPRVCRNSAPASMSPDGTRVIP
RR---SPLSYPAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQ--------------
--------PSPSTSSLSSTHSASPNVTSSAPSSARASPLLSDKHKHSRENSCLSPRERPC
SAIYPTPVEPS-------------------------------------------------
-------QRLLFNHIGDG-ALPRSDPNLSAPEKAVNPTPSSWSLDSGKEAKNMSDGGKLI
SPPVPPRPTQTASPARHTTSV-SPSPAGRSPLK----------------GSMQSFTPSPV
EYH--SPGLISNSPVLSGSYSSGISSLSRCSTSETSGFENQVNEQSVAP----G--SGS-
--------GH-SGSEELVRKESKTPPPYSVYERTLRRPVPLPHSLSIPI------TAEPP
ALPPKPLAARSGHLENG-TRRTDPGPRPRPLPRKVSQLE

---------------------TNLSTEYEMFIASFRGTIPFGLSLEIGDTVQILEKCDGE
WP---------RGIFPSS--YVHLKNACV

PF16172 // ENSGT00610000085806_3_Domain_1 (90, 451)

KNKGQFEMVIPTEDSVITEMTSTLRDWGAMW
KQLYVRNEGDLFHRLWHIMNEILDLRRQVLVGHLTHDRMKDVKRHITARLDWGNEQLGLD
LVPRKEYAMVDPEDISITELYRL---------------------------------MEHR
HRKKDTPVQASSHHLFVQMKSLMCSNLGEELEVIFSLFDSKENRPISERFFLRLNRNGLP
KAPDKPERHCSLFVDLGSSDLRKDIYITVHIIRI---GRMGAGEKKNACSVQYRRPFG--
CAVLSIADLLTGETKDDLVLKVYMCNTESEWYQIHENIIKKLNARYNLTGSNAGLAVSLQ
LLHGDIE-QIRREYSSVFSHGVSITRKLGF

ENSGT00610000085806_3_Linker_1_3 (451, 456)

SNIIM

PF14429 // ENSGT00610000085806_3_Domain_3 (456, 652)

PGEMRNDLYITVERGEFEKGGKSVA
RNVEVTMFIVDSNGQPLKDFISFGSGE------PPASEYHSFVLYH--NNSPRWSELLKL
PIPVDKFRGSHIRFEFRHCSTKEK---GEKKLFGFSFVPLMQEDGRTLPDGTHELIVHKC
EENTNLQDTTRYLKLPFSKVI-FLGNNNQTMKATKESFWITSFLCSTKLTQN---GDMLD
LLKWRTHP----------DKITSCLSKLKEIDGSEIVKFLQDTLDTLFGILDENSQKYGS
KVFDSLVHIINLLQDSKFHHFKPVMDTYIESHFAGA--LAYRDLIKVLKWYVDRITEAER
QEHIQEVLKAQEYIFKYIVQSRRLFSLATGGQNEEEFRCCIQELLMSVRFFLSQESKGAG
ALSQSQAVFLSSFPAVYSELLKLFDVREVANLVQDTLGSLPTIMHVDDSLQAIKLQCIGK
TVE-SQLYTNPDSRYILLPVVLHHLLVHLQEQKDLIMCARILSNVFCLIKKNSSEKSVLE
EIDVIVASLLDILLRTILEITSRPQASSSAMRLQFQDV----------------------
----------------------TGEFVACLLSLLRQMTDRHYQQLLNSFSTKEELRVKDS
GFSQSCQQIFFSILALEISFFLLLFLETGFLCVV-------LELTLSAWLCLPSA---GI
KGVSHHCPAWGFFYLVKRSY----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------

------------------MWIPTEHEK

PF07653 // ENSGT00610000085806_3_Domain_0 (28, 82)

YGVVIASFRGTVPYGLSLEIGDTVQILEKCDGW
YRGFALKNPNIKGIFPSS--YVHLKNACVKNKGQFEMVIPTEDSVITEMTSTLRDWGAMW
KQLYVRNEGDLFHRLWHIMNEILDLRRQVLVGHLTHDRMKDVKRHITARLDWGNEQLGLD
LVPRKEYAMVDPEDISITELYRL---------------------------------MEHR
HRKKDTPVQASSHHLFVQMKSLMCSNLGEELEVIFSLFDSKENRPISERFFLRLNRNGLP
KAPDKPERHCSLFVDLGSSELRKDIYITVHIIRI---GRMGAGEKKNACSVQYRRPFG--
CAVLSIADLLTGETKDDLILKVYMCNTESEWYQIHENIIKKLNARYNLTGSNAGLAVSLQ
LLHGDIE-QIRREYSSVFSHGVSITRKLGFSNIIMPGEMRNDLYITIERGEFEKGGKSVA
RNVEVTMFIVESSGQTLKDFISFGSGE------PPASEYHSFVLYH--NNSPRWSELLKL
PIPVDKFRGAHIRFEFRHCSTKEK---GEKKLFGFSFVPLMQEDGRTLPDGTHELIVHKC
EENTNLQDTTRYLKLPFSKGI-LLGNNNQAVKATKESFWITSFLCSTKLTQN---GDMLD
LLKWRTHP----------DKITGCLSKLKEIDGSEIVKFLQDTLDTLFGILDENSQKYGS
KVFDSLVHIINLLQDSKFHHFKPVMDTYIESHFAGA--LAYRDLIKVLKWYVDRITEAER
QEHIQEVLKAQEYIFKYIVQSRRLFSLATGGQNEEEFRCCIQELLMSVRFFLSQESKGSG
ALSQSQAVFLSSFPAVYSELLKLFDVREVANLVQDTLGSLPTIVHVDDALQAVKLQCIGK
TVE-SQLYTNPDSRYILLPVVLHHLHMHLQEQKDLIMCARILSNVFCLIKKNSSEKSVLE
EIDVIVASLLDILLRTILEITSRPQPSGSTMRLQFQDV----------------------
----------------------TGEFVACLLSLLRQMTDRHYQQLLDSFNTKEELRDFLL
QIFTV-----FRILIRPEM------FPKDWTVMRLVA----NNVIITTVLYLSDALRKNF
LNENFDYKIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKYG-----DMRVTMGCEIF
SMWQNLGEHKLHFIPALIGPFLEVTLIPQPDLRNVMIPIFHDMM------DWEQRRSGNF
KQVEAKLIDKLDSLMSEGKGDETYRELFNSIIPLFG---PYPSLLKKIERETWRESGVSL
IATVTRLMERLLDYRDCMKMGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHL
KAQNFTEAAYTLLLYDELLEWSDRPLREFLTYPMQTEWQRKEHLHLAIIQNFDRGKCWEN
GIILCRKIAEQYESYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLR
NKEFVCRGHDYERLEAFQQRMLNEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPIPES
QEVLQREGVPDNIK

PF06920 // ENSGT00610000085806_3_Domain_5 (1575, 1759)

SFYKVNHIWKFRYDRPFHKGTKDKENEFKSLWVERTSLYLVQSLPG
ISRWFEVEKREVVEMSPLENAIEVLENKNQQLKTLISQCQTRQMQNINPLTMCLNGVIDA
AVNGGVSRYQEAFFVKEYILSHPEDGEKIARLRELMLEQ---AQILEFGLAVHEKFVPQD
MRPLHKKLVDQFFVMKSSLGIQEFSACIQASPVHFPNGSPRVCRNSAPASMSPDGTRVIP
RR---SPLSYPAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQ--------------
--------PSPSTSSLSSTHSASPNVTSSAPSSARASPLLSDKHKHSRENSCLSPRERPC
SAIYPTPVEPS-------------------------------------------------
-------QRLLFNHIGDG-ALPRSDPNLSAPEKAVNPTPSSWSLDSGKEAKSTAGGGKLP
SPPVPPRPAQTASPARHTSSV-SPSPAGRSPLK----------------GSVQSFTPSPV
EYH--SPGLISNSPVLSGSYSSGISSLSRCSTSETSGFENQVNEPSAAPLGSG-------
-------PGYGGGSEEPVRKESKTPPPYSVYERTLRRPVPLPHSLSIPV------TAEPP
ALPPKPLAARSGHLENG-TRRTDPGPRPRPLPRKVSQL-

------------------------------VIASFRGTVPYGLSLEIGDTVQILEKCDGW
YRGFALKNPNIKGIFPSS--YVHLKNACV

PF16172 // ENSGT00610000085806_3_Domain_1 (90, 451)

KNKGQFEMVIPTEDSVITEMTSTLRDWGSMW
KQLYVRNEGDLFHRLWHIMNEILDLRRQVLVGHLTHDRMKDVKRHITARLDWGNEQLGLD
LVPRKEYAMVDPEDISITELYRL---------------------------------MEHR
HRKKDTPVQASSHHLFVQMKSLMCSNLGEELEVIFSLFDSKENRPISERFFLRLNRNGLP
KAPDKPERHCSLFVDLGSSELRKDIYITVHIIRI---GRMGAGEKKNACSVQYRRPFG--
CAVLSIADLLTGETKDDLVLKVYMCNTESEWYQIHENIIKKLNARYNLTGSNAGLAVSLQ
LLHGDIE-QIRREYSSVFSHGVSITRKLGF

ENSGT00610000085806_3_Linker_1_3 (451, 456)

SDIIM

PF14429 // ENSGT00610000085806_3_Domain_3 (456, 652)

PGEMRNDLYITVERGEFEKGGKSVA
RNVEVTMFIVDSNGQPLKDFISFGSGE------PLASEYHSFVLYH--NNSPRWSELLKL
PIPVDKFRGSHIRFEFRHCSTKEK---GEKKLFGFSFVPLMQEDGRTLPDGTHELIVHKC
EENTNLQDTTRYLKFPFSKVI-FLGNNNQTMKATKESFWITSFLCSTKLTQ

ENSGT00610000085806_3_Linker_3_5 (652, 1250)

N---GDMLD
LLKWRTHP----------DKITGCLSKLKEIDGSEIVKFLQDTLDTLFGILDENSQKYGS
KVFDSLVHIINLLQDSKFHHFKPVMDTYIESHFAGA--LAYRDLIKVLKWYVDRITEAER
QEHIQEVLKAQEYIFKYIVQSRRLFSLATGGQNEEEFRCCIQELLMSVRFFLSQESKGTG
ALSQSQAVFLSSFPAVYSELLKLFDVREVANLVQDTLGSLPTIMHVDDSLQAIKLQCIGK
TVE-SQLYTNPDSRYILLPVVLHHLHIHLQEQKDLIMCARILSNVFCLIKKNSSEKSVLE
EIDVIVASLLDILLRTILEITSRPQASSSAMRLQFQDV----------------------
----------------------TGEFVACLLSLLRQMTDRHYQQLLNSFNTKEELRDFLL
QIFTV-----FRILIRP-----EMF-PKDWTVMRLVA---NN-VIITTVLYLSDALRKNF
LNENFDYKIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKYG-----DMRVTMGCEIF
SMWQNLGEHKLHFIPALIGPFLEVTLIPQPDLRNVMIPIFHDMM-----

PF06920 // ENSGT00610000085806_3_Domain_5 (1250, 1757)

-DWEQRRSGNF
KQVEAKLIDKLDSLMSEGKGDETYRELFNSIIPLFGP---YPSLLKKIERETWRESGVSL
IATVTRLMERLLDYRDCMKIGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHL
KAQNFTVYCFPLCMLVEIMEWPGRPLHTDSSYPMVTEEKRKEMLYTCVVKLCYRGMCWEN
GIILCRKIAEQYESYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLR
NKEFVCRGHDYERLEAFQQRMLNEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPIPES
QEVLQREGVPDNIKSFYKVNHIWKFRYDRPFHKGTKDKENEFKSLWVERTSLYLVQSLPG
ISRWFEVEKREVVEMSPLENAIEVLENKNQQLKTLISQCQSRQMQNINPLTMCLNGVIDA
AVNGGVSRYQEAFFVKDYILSHPEDGEKIARLRELMLEQ---AQILEFGLAVHEKFVPQD
MRPLHKKLVDQFFVMKSSFGIQEFPACIQASPVHFPNGSPRVCRNSAPASMSPDGTRVIP
RR---SPLSYPAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQ--------------
--------PSPSTSSLSSTHSASPNVTSSAPSSARASPLLSDKHKHSRENSCLSPRDRPC
SAIYPTPVEPS-------------------------------------------------
-------QRMLFNHIGDG-ALPRSDPNLSAPEKAVNPTPSSWSLDSGKEAKNMSDSGKLI
SPPVPPRPTQTASPARHTTSV-SPSPAGRSPLK----------------SSVQSFTPSPV
EYN--SPGLSSNSPVLSGSYSSGISSLSRCSTSETSGFENQANEQSVPVPVPVPVPMPVP
---------SFSGSEEPVRKESKTPPPYSVYERTLRRPVPLPHSLSIPV------TSEPP
ALPPKPLAARSSHLENG-TRRTEPGPRPRPLPRKVSQL-

------------------MWIPTEHEK

PF07653 // ENSGT00610000085806_3_Domain_0 (28, 82)

YGVVIAGFRGTVPHGLSLEIGDTVQILEKCDGW
YRGFALKNPNVKGIFPSN--YIHLKNACVKNKGQFEMVIPTEDSVITEMTSTLRDWGTMW
KQLYVRNEGDLFHRLWHIMNEILDLRRQVLVGHLTHDRMKDVKRHITARLDWGNEQLGLD
LVPRKEYAMVDPEEISITELYRL---------------------------------MEHR
HRKKDTPVPASSHHLFVQMKSLMCSNLGEELEVIFSLFDSKENRPISERFFLRLNRNGLP
KCPEKPERHCSLFVDLGSSELRKDIYITVHIIRI---GRMGAGEKKNACNVQYRRPFG--
CAVLSIADLLAGDSKDDLVLKVYMCNTESDWYQIHENIIKKLNARYNLTGSNAGLAVSLQ
LLHGDIE-QIRREYTSRFTHGVSITRKLGFSNIIMPGEMRNDLYITVERGEFEKGGKSVA
RNVEVTMHVVDSSGQILKDFISFGSGE------PPASEYHSFVLYH--NNGPRWAELLKL
PIPVDKFRGAHIRCEFRHCSTKEK---GEKKLFGFSFVPLMQENGRTLPDGTHELIVHKC
EENANLQDSGRYLKLPFSKGI-SLGSNSQAVKSTKESFWITSFLCSTKLTQN---GDMLD
LLKWRTHP----------DKIAGCLSKLKEIDGSEIVKFLQDTLDTLFGILDENSQKYGS
KVFDCLVHIINLLQDSKFHHFKPVMDTYIESHFAGA--LAYRDLIKVLKWHIDRVTEVEL
HDHIQEVLKAQEYIFKYIVQSRRLFSIATGGQNEEEFRCCIQELLMSVRFFLSQESKGTS
ALSQLQAVFLSSFPSVYSELLKLFDVREVANLVHDALGSLPTVMHGDESLQAVKLQSIGK
TVE-SHLYTNPDSRCILLPVVLHHLHMHLQEQKDLIMCARILSNIFCLIKKNSSEKSVLE
EIDVIVNSLLDILLRTILEITSRPQPSGSAMRLQFQDVTTFDSFLSSSMLQSDLTETIQ-
---CFSPVQKKHYNISPLGLSEQGEFVSCLLSLLRQMTDRHYQQLLDSFNTKEDLRDFLL
QIFTV-----FRILIRP-----EMF-PKDWTVMRLVA---NN-VIITTVLYLSDALRKNF
LNENFDYKIWDSYFFLAVIFINQLCLQLEMFTPSKKKKVLEKYG-----DMRVTMGCEIF
SMWQNLGEHKLHFIPALIGPFLEVTLIPQPDLRNVMIPIFHDMM------DWEQRRSGNF
KQVEAKLIDKLDSLMSEGKGDETYRELFNSIIPLFGP---YPSLLKKIERETWRESGVSL
IATVTRLMERLLDYRDCMKMGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHL
KAQNFTEAAYTLLLYDELLEWSDRPLREFLTYPMQTEWQRKECLHLTIIQNFDRGKCWEN
GIILCRKIAEQYESYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLR
NKEFVCRGHDYERLEAFQQRMLNEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPIPEN
QEVLQRDGIPDNIK

PF06920 // ENSGT00610000085806_3_Domain_5 (1575, 1759)

SFYKVNHIWRFRYDRPFHKGTKDKENEFKSLWVERTTLILVQSLPG
ISRWFEVEKREVVEMSPLENAIEVLENKNQQLRTLISQCQTRQMQNINPLTMCLNGVIDA
AVNGGVARYQEAFFIKEYILNHPEDGEKITRLRELMLEQ---AQILEFGLAVHEKVVPQD
MRPLHKKLVDQFFVMKSSLGIQEFSACVQASPVHFPNGSPRVCRNSIPISMSPDAARVIP
RR---SPLSYPAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQ--------------
--------PSPSTSSLSSTHSASPNVTSSAPSSARASPLLSDKHKHSRENSCLSPRERPC
SAIYPTPLETS-------------------------------------------------
-------QRMLFNHIGDG-ALPRSDSNLPGADKAVNTTPSSWSLDSGKEARNTSESGKLI
SPPVPPRPVQTASPARHIASI-SPSPAGRSPMK----------------GSVQSFTPSPV
EYH--SSGLISNSPALSGSYSSGISSLSRCSTSETSGFESQGSEPAV---------TVP-
--------SY-SISEEPVRKESKTPPPYSVYERTLKRPVPLPHSLSIPP------AADPP
ALPPKPQLVRPNNLENS-SRRTEQVPRPRPLPRKVSQL-

------------------MIAFIYSMSFLTVIASFRGTVPYGLSLEIGDTVQILEKCDGW
YRGFALKNPNIKGIFPSS--YVHLKNACV

PF16172 // ENSGT00610000085806_3_Domain_1 (90, 451)

KNKGQFEMVIPTEDSVITEMTSTLRDWGTMW
KQLYVRNEGDLFHRLWHIMNEILDLRRQVLVGHLTHDRMKDVKRHITARLDWGNEQLGLD
LVPRKEYAMVDPEDISITELYRL---------------------------------MEHR
HRKKDTPVQASSHHLFVQMKSLMCSNLGEELEVIFSLFDSKENRPISERFFLRLNRNGLP
KAPDKPERHCSLFVDLGSSELRKDIYITVHIIRI---GRMGAGEKKNACSVQYRRPFG--
CAVLSIADLLTGETKDDLVLKVYMCNTESEWYQIHENIIKKLNARYNLTGSNAGLAVSLQ
LLHGDIE-QIRREYSSVFSHGVSITRKLGF

ENSGT00610000085806_3_Linker_1_3 (451, 456)

SNIIM

PF14429 // ENSGT00610000085806_3_Domain_3 (456, 652)

PGEMRNDLYITIERGEFEKGGKSVA
RNVEVTMFIVDSSGQTLKDFISFGSGE------PPASEYHSFVLYH--NNSPRWSELLKL
PIPVDKFRGAHIRFEFRHCSTKEK---GEKKLFGFSFVPLMQEDGRTLPDGTHELIVHKC
EENTNLQDTTRYLKLPFSKGI-FLGNNNQAMKATKESFWITSFLCSTKLTQ

ENSGT00610000085806_3_Linker_3_5 (652, 1250)

N---GNGKK
IPHD------------------------------AHFRFI--------GIS---------
-------------------------LKVQPTLLCAHFSLYFRDLIKVLKWYVDRITEAER
QEHIQEVLKAQEYIFKYIVQSRRLFSLATGGQNEEEFRCCIQELLMSVRFFLSQESKGSG
ALSQSQAVFLSSFPAVYSELLKLFDVREVANLVQDTLGSLPTIMHVDDSLQAIKLQCIGK
TVE-SQLYTNPDSRYILLPVVLHHLHIHLQEQKDLIMCARILSNVFCLIKKNSSEKSVLE
EIDVIVASLLDILLRTILEITSRPQPSGSTMRLQFQDV----------------------
----------------------TGEFVACLLSLLRQMTDRHYQQLLDSFNTKEELRDFLL
QIFTV-----FRILIRP-----EMF-PKDWTVMRLVA---NN-VIITTVLYLSDALRKNF
LNENFDYKIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKYG-----DMRVTMGCEIF
SMWQNLGEHKLHFIPALIGPFLEVTLIPQPDLRNVMIPIFHDMM-----

PF06920 // ENSGT00610000085806_3_Domain_5 (1250, 1759)

-DWEQRRSGNF
KQVEAKLIDKLDSLMSEGKGDETYRELFNSIIPLFGP---YPSLLKKIERETWRESGVSL
IATVTRLMERLLDYRDCMKMGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHL
KAQNFTEAAYTLLLYDELLEWSDRPLREFLTYPMQTEWQRKEHLHLTIIQNFDRGKCWEN
GIILCRKIAEQYESYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLR
NKEFVCRGHDYERLEAFQQRMLNEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPIPES
QEVLQREGVPDNIKSFYKVNHIWKFRYDRPFHKGTKDKENEFKSLWVERTSLYLVQSLPG
ISRWFEVEKREVVEMSPLENAIEVLENKNQQLKTLISQCQTRQMQNINPLTMCLNGVIDA
AVNGGVSRYQEAFFVKEYILSHPEDGEKIARLRELMLEQ---AQILEFGLAVHEKFVPQD
MRPLHKKLVDQFFVMKSSLGIQEFSACIQASPVHFPNGSPRVCRNSAPASMSPDGTRVIP
RR---SPLSYPAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQ--------------
--------PSPSTSSLSSTHSASPNVTSSAPSSARASPLLSDKHKHSRENSCLSPRERPC
SAIYPTPVEPS-------------------------------------------------
-------QRMLFNHIGDG-ALPRSDPNLSAPEKAVNPTPSSWSLDSGKEAKNMSDSGKLI
SPPVPPRPTQNASPARHTTSV-SPSPAGRSPLK----------------GSVQSFTPSPV
EYH--SPGLISNSPVLSGSYSSGISSLSRCSTSETSGFENQVNEQAAPVSVSSY------
--------AG-PGPEEPVRKESKTPPPYSVYERTLRRPVPLPHSLSIPV------TSEPP
ALPPKPLTARTSHLENG-TRRTEPGPRPRPLPRKVSQL-

------------------------------VIASFRGTVPYGLSLEIGDTVQILEKCDXX
XXXXXXXXXXXXXXXXXX--XXXXXXXXXXXXXQFEMIIPTEDSVITEMTSTLRDWGTMW
KQLYVRNEGDLFHRLWHIMNEILDLRRQVLVGHLTHDRMKDVKRHITARLDWGNXXXXXX
XXXXXXXXXX-----------------XXXX----------------XXXXXXXXXMEHR
HRKKDTPVQASSHHLFVQMKSLMCSNLGEELEVIFSLFDSKENRPISERFFLRLNRNGLP
KAPDKPERHCSLFVDLGSSELRKDVYITVHIIRI---GRMGAGEKKNACSVQYRRPFG--
CAVLSIADLLTGETKDDLVLKVYMCNTESEWYQIHENIIKKLNARYNLTGSNAGLAVSLQ
LLHGDME-QMRREYSSVFSHGVSITRKLGFSNIIMPGEMRNDLYITIERGEFEKGGKSVA
RNVEVAMFIIDSSGQTLKDFISFGSGE------PPASDYHSFVLYH--NNSPRWSELLKL
PIPVDKFRGAHVRFEFRHCSTKEK---GEKKLFGFSFVPLMQEDGRTLPDGTHELIVHKC
EENTNLQDPTHYLKLPFSKGL-LLGHNNPAMKATKESFWITSFLCSTKLTQNXXXXXXXX
XXXXXXXX----------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXX-XXX-XXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXX-XXXXXXXXSRYILLPVVLHHLHMHLQAQKDLIMCARILSNVFCLIKKNSSEKSVLE
EIDVIVASLLDILLRTVLEITSRPQPSGSALRLQFQDV----------------------
----------------------TGEFVACLLSLLRQMTDRHYQQLLDSFNTKEDLRXXXX
XXXXXXXXXXX---------------XXXXXXXXXXXXXXXXXVIITTVLYLSDALRKNF
LNENFDYKIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKYG-----DMRVTMGCEIF
SMWQNLGEHKLHFIPALIGPFLEVTLIPQPDLRNVMIPIFHDMM------DWEQRRSG-F
KQVEAKLIDKLDSLMSEGKGDETYRELFNSIIPLFGP---YPSLLKKIERETWRESGVSL
IATVTRLMERLLDYRDCMKMGEVDGKKIGCTVSLLXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXAAYTLLLYDELLEWSDRPLREFLTYPMQTEWQRKEHLHLTVIQNFDRGRCWEN
GVILCRKIAEQYESYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLR
NKEFVCRGHDYERLEAFQQRMLNEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPIPES
QEVLQREGVPDNI

PF06920 // ENSGT00610000085806_3_Domain_5 (1574, 1761)

KSFYKVNHIWKFRYDRPFHKGTKDKENEFKSLWVERTSLYLVQSLPG
ISRWFEVEKRDVVEMSPLENATEVLENKNQQLKTLISQCQTRQMQNINPLTMCLNGVIDA
AVNGGVSRYQEAFFVKDYILSHPEDGEKIARLRELMLEQ---AQILEFGLAVHEKFVPQD
MRPLHKKLVDQFFVMKSSLGIQEFSACLQASPVHFPNGSPRVCRNSAPASMSPDGTRVIP
RR---SPLSYPAINRYSSSSLSSQASAEVSNITGQSESSDEVFNMQ--------------
--------PSPSTSSLSSTHSASPNVTSSAPSSARASPLLSDKHKHSRENACLSPRERPC
SAIFPTPVEPS-------------------------------------------------
-------QRMLFNHIGDG-ALSRSDPNLCASEITVNPTPSSWSLDSGKEAKTMSDSGKLL
SPPVPPRPTLTXXXXXXXXXXX-----------------XXXXXXXXXXGSVQSFTPSPV
EFH--CPGLISNSPGLSGSYSSGISSLSRCSTSETSGFENQGTEPPAPGLVPVPVPVA--
-------MSGYSAPEEPVRKESKTPPPYSVYERTLRRPVPLPHSLSIPV------TSEPP
ALPPKPLPARSSHLENG-TRRTEPGSRPRPLPRKVSQL-

------------------MIIFIYSITFLAV

PF07653 // ENSGT00610000085806_3_Domain_0 (32, 82)

IASFRGTVPYGLSLEIGDTVQILEKCDGW
YRGFALKNPNVKGIFPSS--Y

ENSGT00610000085806_3_Linker_0_1 (82, 90)

VHLKNACV

PF16172 // ENSGT00610000085806_3_Domain_1 (90, 451)

KNKGQFEMVIPTEDSVITEMTSTLRDWGTMW
KQLYVRNEGDLFHRLWHIMNEILDLRRQVLVGHLTHDRMKDVKRHITARLDWGNEQLGLD
LVPRKEYAMVDPEDISITELYRL---------------------------------MEHR
HRKKDTPVQASNHHLFVQMKSLMCSNLGEELEVIFSLFDSKENRPISERFFLRLNRNGLP
KAPDKPERHCSLFVDLGSSELRRDIYITVHIIRI---GRMGAGEKKNACSVQYRRPFG--
CAVLSIADLLTGETKDDLILKVYMCNTESEWYQIHENIIKKLNARYNLTGSNAGLAVSLQ
LLHGDIE-QIRREYSSVFSHGVSITRKLGF

ENSGT00610000085806_3_Linker_1_3 (451, 456)

SNIIM

PF14429 // ENSGT00610000085806_3_Domain_3 (456, 652)

PGEMRNDLYITIERGEFEKGGKSVA
RNVEVTMFIVESSGQILKDFISFGSGE------PPASEYHSFVLYH--NNSPRWSELLKL
PIPVDKFRGAHIRFEFRHCSTKEK---GEKKLFGFSFVPLMQEDGRTLPDGTHELIVHKC
EENTNLQDTTRYLKLPFSKGI-LLGNNHQAMKATKESFWITSFLCSTKLTQ

ENSGT00610000085806_3_Linker_3_5 (652, 1427)

N---GDMLD
LLKWRTHP----------DKITGCLSKLKEIDGSEIVKFLQDTLDTLFGILDENSQKYGS
KVFDSLVHIINLLQDSKFHHFKPVMDTYIESHFAGA--LAYRDLIKVLKWYVDRITEAER
QEHIQEVLKAQEYIFKYIVQSRRLFSLATGGQNEEEFRCCIQELLMSVRFFLSQESKGSG
ALSQSQAVFLSSFPAVYSELLKLFDVREVANLVQDTLGSLPTIVHVDDSLQAVKLQCIGK
TVE-SQLYTNPDSRYILLPVVLHHLHMHLQEQKDLIMCARILSNVFCLIKKNSSEKSVLE
EIDVIVASLLDILLRTILEITSRPQSSGSAMRLQFQDV----------------------
----------------------TGEFVACLLSLLRQMTDRHYQQLLDSFNTKEELRDFLL
QIFTV-----FRILIRP-----EMF-PKDWTVMRLVA---NN-VIITTVLYLSDALRKNF
LNENFDYKIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKYG-----DMRVTMGCEIF
SMWQNLGEHKLHFIPALIGPFLEVTLIPQPDLRNVMIPIFHDMM------DWEQRRTGNF
KQVEAKLIDKLDSLMSEGKGDETYRELFNSIIPLFGP---YPSLLKKIERETWRESGVSL
IATVTRLMERLLDYRDCMKMGEVDGKKIGCTVSLLPHSRGSCLGPC----------LNHC
LPTWLAEAAYTLLLYDELLEWSDRPLREFLTYPMQTEWQRKEHLHL

PF06920 // ENSGT00610000085806_3_Domain_5 (1427, 1759)

AIIQNFDRGKCWEN
GIILCRKIAEQYESYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLR
NKEFVCRGHDYERLEAFQQRMLNEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPIPES
QEVLQREGVPDNIKSFYKVNHIWKFRYDRPFHKGTKDKENEFKSLWVERTSLYLVQSLPG
ISRWFEVEKREVVEMSPLENAIEVLENKNQQLKTLISQCQTRQMQNINPLTMCLNGVIDA
AVNGGVSRYQEAFFVKEYILSHPEDGEKIARLRELMLEQ---AQILEFGLAVHEKFVPQD
MRPLHKKLVDQFFVMKSSLGIQEFSACIQASPVHFPNGSPRVCRNSAPASMSPDGTRVIP
RR---SPLSYPAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQ--------------
--------PSPSTSSLSSTHSASPNVTSSAPSSARASPLLSDKHKHSRENSCLSPRERPC
SAIYPTPGETS-------------------------------------------------
-------QRLLFNHIGDG-ALPRSDPNLSAPEKAVNPTPSSWSLDSGKEAKNMSDSGKIL
SPPVPPRPTQTASPARHTTS-VSPSPAGRSPLK----------------GSVQSFTPSPV
EYH--SPGLISNSPVLSGSYSSGISSLSRCSTSETSGFENQVNEQSAPAAGP--------
--------G-YSGPEEPVRKESKTPPPYSVYERTLRRPVPLPHSLSIPV------TAEPP
ALPPKPLAARPGHLENG-TRRTEPGPRPRPLPRKVSQL-

------------------MIIPIYSVSFLTVIASFRGTVPYGLSLEIGDTVQILEKCDGW
YRGFALKNPNIKGIFPSS--YVHLKNACV

PF16172 // ENSGT00610000085806_3_Domain_1 (90, 451)

KNKGQFEMVIPTEDSVITEMTSTLRDWGAMW
KQLYVRNEGDLFHRLWHIMNEILDLRRQVLVGHLTHDRMKDVKRHITARLDWGNEQLGLD
LVPRKEYAMVDPEDISITELYRL---------------------------------MEHR
HRKKDTPVQASSHHLFVQMKSLMCSNLGEELEVIFSLFDSKENRPISERFFLRLNRNGLP
KAPDKPERHCSLFVDLGSSELRKDIYITVHIIRI---GRMGAGEKKNACSVQYRRPFG--
CAVLSIADLLTGETKDDLILKVYMCNTESEWYQIHENIIKKLNARYNLTGSNAGLAVSLQ
LLHGDIE-QIRREYSSVFSHGVSITRKLGF

ENSGT00610000085806_3_Linker_1_3 (451, 456)

SNIIM

PF14429 // ENSGT00610000085806_3_Domain_3 (456, 652)

PGEMRNDLYITIERGEFEKGGKSVA
RNVEVTMFIVESSGQTLKDFISFGSGE------PPASEYHSFVLYH--NNSPRWSELLKL
PIPVDKFRGAHIRFEFRHCSTKEK---GEKKLFGFSFVPLMQEDGRTLPDGTHELIVHKC
EENTNLQDTTRYLKLPFSKGI-LLGNNNQAVKATKESFWITSFLCSTKLTQ

ENSGT00610000085806_3_Linker_3_5 (652, 1297)

N---GDMLD
LLKWRTHP----------DKITGCLSKLKEIDGSEIVKFLQDTLDTLFGILDENSQKYGS
KVFDSLVHIINLLQDSKFHHFKPVMDTYIESHFAGA--LAYRDLIKVLKWYVDRITEAER
QEHIQEVLKAQEYIFKYIVQSRRLFSLATGGQNEEEFRCCIQELLMSVRFFLSQESKGSG
ALSQSQAVFLSSFPAVYSELLKLFDVREVANLVQDTLGSLPTIVHVDDALQAVKLQCIGK
TVE-SQLYTNPDSRYILLPVVLHHLHMHLQEQKDLIMCARILSNVFCLIKKNSSEKSVLE
EIDVIVASLLDILLRTILEITSRPQPSGSTMRLQFQDV----------------------
----------------------TGEFVACLLSLLRQMTDRHYQQLLDSFNTKEELRDFLL
QIFTV-----FRILIRPEM------FPKDWTVMRLVA----NNVIITTVLYLSDALRKNF
LNENFDYKIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKYG-----DMRVTMGCEIF
SMWQNLGEHKLHFIPALIGPFLEVTLIPQPDLRNVMIPIFHDMM------DWEQRRSGNF
KQVGGCALRAVRRISVLSEVSA-----VAQRCSEFQ

PF06920 // ENSGT00610000085806_3_Domain_5 (1297, 1759)

PRPRTSNLLKKIERETWRESGVSL
IATVTRLMERLLDYRDCMKMGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHL
KAQNFTEAAYTLLLYDELLEWSDRPLREFLTYPMQTEWQRKEHLHLAIIQNFDRGKCWEN
GIILCRKIAEQYESYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLR
NKEFVCRGHDYERLEAFQQRMLNEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPIPES
QEVLQREGVPDNIKSFYKVNHIWKFRYDRPFHKGTKDKENEFKSLWVERTSLYLVQSLPG
ISRWFEVEKREVVEMSPLENAIEVLENKNQQLKTLISQCQTRQMQNINPLTMCLNGVIDA
AVNGGVSRYQEAFFVKEYILSHPEDGEKIARLRELMLEQ---AQILEFGLAVHEKFVPQD
MRPLHKKLVDQFFVMKSSLGIQEFSACIQASPVHFPNGSPRVCRNSAPASMSPDGTRVIP
RR---SPLSYPAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQ--------------
--------PSPSTSSLSSTHSASPNVTSSAPSSARASPLLSDKHKHSRENSCLSPRERPC
SAIYPTPVEPS-------------------------------------------------
-------QRLLFNHIGDG-ALPRSDPNLSAPEKAVNPTPSSWSLDSGKEAKSTAGGGKLP
SPPVPPRPAQTASPARHTASV-SPSPAGRSPLK----------------GSVQSFTPSPV
EYH--SPGLISNSPVLSGSYSSGISSLSRCSTSETSGFENQVNEPSAAPLGSG-------
-------PGYGGGSEEPVRKESKTPPPYSVYERTLRRPVPLPHSLSIPV------TAEPP
ALPPKPLAARSGHLENG-TRRTDPGPRPRPLPRKVSQL-

---------------------------FSTVIASFRGTVPYGLSLEIGDTVQILEKCDGW
YRGFALKNPNIKGIFPSS--YVHLKNACVKNKGQ---------------------WGTLW
RDYG-----------------------------------------------CIR

PF16172 // ENSGT00610000085806_3_Domain_1 (175, 451)

RQLGLD
LVPRKEYAMVDPEDISITELYRL---------------------------------MEHR
HRKKDTPVQASSHHLFVQMKSLMCSNLGEELEVIFSLFDSKENRPISERFFLRLNRNGLP
KAPDKPERHCSLFVDLGSSDLRKDIYITVHIIRI---GRMGAGEKKNACSVQYRRPFG--
CAVLSIADLLTGETKDDLVLKVYMCNTESEWYQIHENIIKKLNARYNLTGSNAGLAVSLQ
LLHGDIE-QIRREYSSVFSHGVSITRKLGF

ENSGT00610000085806_3_Linker_1_3 (451, 456)

SNIIM

PF14429 // ENSGT00610000085806_3_Domain_3 (456, 652)

PGEMRNDLYITVERGEFEKGGKSVA
RNVEVTMFIVDSNGQPLKDFISFGSGE------PPSSEYHSFVLYH--NNSPRWSELLKL
PIPVDKFRGSHIRFEFRHCSTKEK---GEKKLFGFSFVPLMQEDGRTLPDGTHELIVHKC
EENTNLQDTTRYLKLPFSKVI-FLGNNNQTMKATKESFWITSFLCSTKLTQ

ENSGT00610000085806_3_Linker_3_5 (652, 1250)

N---GDMLD
LLKWRTHP----------DKITGCLSKLKEIDGSEIVKFLQDTLDTLFGILDENSQKYGS
KVFDSLVHIINLLQDSKFHHFKPVMDTYIESHFAGA--LAYRDLIKVLKRYVDRITEAER
QEHIQEVLKAQEYIFKYIVQSRRLFSLATGGQNEEEFRCCIQELLMSVRFFLSQDSKGAG
ALSQSQAVFLNSFPAVYSELLKLFDVREVANLVQDTLGSLPTIMHVDDSLQAIKLQCIGK
TVE-SQLYTNPDSRYILLPVVLHHLHIHLQEQKDLIMCARILSNVFCLIKKNSSEKSVLE
EIDVIVASLLDILLRTILEITSRPQATSSAMRLQFQDV----------------------
----------------------TGEFVACLLSLLRQMTDRHYQQLLNSFNTKEELRDFLL
QIFTV-----FRILIRPE------MFPKDWTVMRLVA----NNVIITTVLYLSDALRKNF
LNENFDYKIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKYG-----DMRVTMGCEIF
SMWQNLGEHKLHFIPALIGPFLEVTLIPQPDLRNVMIPIFHDMM-----

PF06920 // ENSGT00610000085806_3_Domain_5 (1250, 1757)

-DWEQRRSGNF
KQVEAKLIDKLDSLMSEGKGDETYRELFNIGSI---Q---DICLLKKIERETWRESGVSL
IATVTRLMERLLDYRDCMKMGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHL
KAQNFTEAAYTLLLYDELLEWSDRPLREFLTYPMQTEWQRKEHLHLTIIQNFDRGKCWEN
GIILCRKIAEQYESYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLR
NKEFVCRGHDYERLEAFQQRMLNEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPIAES
REALQREGVPDNIKSFYRVNHIWKFRYDRPFHKGTKDKENEFKSLWVERTSLYLVQSLPG
ISRWFEVEKREVVEMSPLENAIEVLENKSQQLKALISQCQTRQMQNINPLTMCLNGVIDA
AVNGGVSRYQEAFFVKDYILSHPEDGEKIARLRELMLEQ---AQILEFGLAVHEKFVPQD
MRPLHKKLVDQFFVMKSSFGIQEFPACFQASPVHFPNGSPRVCRNSAPASMSPDGTRVIP
RR---SPLSYPAVNRYSSSSLSSQASAEVSNITGHSESSDEVFNMQ--------------
--------PSPSTSSLSSTHSASPNVTSSAPSSARASPLLSDKHKHSRENSCLSPRDRPC
SAIYPTPAEPS-------------------------------------------------
-------QRTLFNHIGDG-ALPRSDPNLSAPEKAVNPTPSSWSLDSGKEAKNMSDGGKLI
SPPVPPRPTQTASPARHTTSV-SPSPAGRSPLK----------------GSVQSFTPSPV
EYN--SPGLSSNSPVLSGSYSSGISSLSRCSTSETSGFENQASEQSVPV----------P
VPVPMPVPSF-SGSEEPVRKESKTPPPYSVYERTLRRPVPLPHSLSIPV------TSEPP
ALPPKPLAARSSHLENG-TRRTEPGPRPRPLPRKVSQL-

------------------------------VIASFRGTVPYGLSLEIGDTVQILEKCDGW
YRGFALKNPNIKGIFPSS--YVHLKNACVKNKGQFEMVIPTEDSVITEMTSTLRDWGTMW
KQLYVRNEGDLFHRLWHIMNEILDLRRQVLVGHLTHDRMKDVKRHITARLDWGNEQLGLD
LVPRKEYAMVDPEDISITELYRL---------------------------------MEHR
HRKKDTPVQASSHHLFVQMKSLMCSNLGEELEVIFSLFDSKENRPISERFFLRLNRNGLP
KAPDKPERHCSLFVDLGSSELRKDIYITVHIIRI---GRMGAGEKKNACSVQYRRPFG--
CAVLSIADLLTGETKDDLILKVYMCNTESEWYQIHENIIKKLNARYNLTGSNAGLAVSLQ
LLHGDIE-QIRREYSSVFSHGVSITRKLGFSNIIMPGEMRNDLYITIERGEFEKGGKSVA
RNVEVTMFIVDSSGQTLKDFISFGSGE------PPASEYHSFVLYH--NNSPRWSELLKL
PIPVDKFRGAHIRFEFRHCSTKEK---GEKKLFGFSFVPLMQEDGRTLPDGTHELIVHKC
EENTNLQDTTRYLKLPFSKGI-FLGNNNQAMKATKESFCITSFLCSTKLTQN---GDMLD
LLKWRTHP----------DKITGCLSKLKEIDGSEIVKFLQDTLDTLFGILDENSQKYGS
KVFDSLVHIINLLQDRKFHHLKPVMDTYIESHFAGA--LAYRDLIKVLKWYVDRITEAER
QEHIQEVLKAQEYIFKYIVQSRRLFSLATGGQNEEEFRCCIQELLMSVRFFLSQESKGSG
ALSQSQAVFLSSFPAVYSELLKLFDVREVANLVQDTLGSLPTILHVDDSLQAIKLQCIGK
TVE-SQLYTNPDSRYILLPVVLHHLHIHLQEQKDLIMCARILSNVFCLIKKNSSEKSVLE
EIDVIVASLLDILLRTILEITSRPQPSSSAMRFQFQDV----------------------
----------------------TGEFVACLLSLLRQMTDRHYQQLLDSFNTKEELRDFLL
QIFTV-----FRILIRP-----EMF-PKDWTVMRLVA---NN-VIITTVLYLSDALRKNF
LNENFDYKIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKYG-----DMRVTMGCEIF
SMWQNLGEHKLHFIPALIGPFLEVTLIPQPDLRNVMIPIFHDMM------DWEQRRSGNF
KQVEAKLIDKLDSLMSEGKGDETYRELFNSIIPLFGP---YPSLLKKIERETWRESGVSL
IATVTRLMERLLDYRDCMKMGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHL
KAQNFTEAAYTLLLYDELLEWSDRPLREFLTYPMQTEWQRKEHLHLTIIQNFDRGKCWEN
GIILCRKIAEQYESYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLR
NKEFVCRGHDYERLEAFQQRMLNEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPIPES
QEVLQREGVPDNIK

PF06920 // ENSGT00610000085806_3_Domain_5 (1575, 1759)

SFYKVNHIWKFRYDRPFHKGTKDKENEFKSLWVERTSLYLVQSLPG
ISRWFEVEKREVVEMSPLENAIEVLENKNQQLKTLISQCQTRQMQNINPLTMCLNGVIDA
AVNGGVSRYQEAFFVKEYILSHPEDGEKIARLRELMLE--------QFGLAVHEKFVPQD
MRPLHKKLVDQFFVMKSSLGIQEFSACMQASPVHFPNGSPRVCRNSAPASVSPDGTRVIP
RR---SPLSYPAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQ--------------
--------PSPSTSSLSSTHSASPNVTSSAPSSARASPLLSDKHKHSRENSCLSPRERPC
SAIYPTPVEPS-------------------------------------------------
-------QRMLFNHIGDG-ALPRSDPNLSAPEKAVNPTPSSWSLDSGKEAKNMSDSGKLI
SPPVPPRPTQTASPARHTTSV-SPSPAGRSPLK----------------GSVQSFTPSPV
EYH--SPGLISNSPVLSGSYSSGISSLSRCSTSETSGFENQVNEQSAPLPVPV-------
----PVPVPS-YGGEEPVRKESKTPPPYSVYERTLRRPVPLPHSLSIPV------TPEPP
ALPPKPLAARSSHLENG-ARRTDPGPRPRPLPRKVSQL-

------------------WLPSYILYHFFIVIASFRGTVPYGLSLEIGDTVQILEKCDGW
YRGFALKNPNIKGIFPSS--YVHLKNACV

PF16172 // ENSGT00610000085806_3_Domain_1 (90, 451)

KNKGQFEMVIPTEDSVITEMTSTLRDWGTMW
KQLYVRNEGDLFHRLWHIMNEILDLRRQVLVGHLTHDRMKDVKRHITARLDWGNEQLGLD
LVPRKEYAMVDPEDISITELYRL---------------------------------MEHR
HRKKDTPVQASSHHLFVQMKSLMCSNLGEELEVIFSLFDSKENRPISERFFLRLNRNGLP
KAPDKPERHCSLFVDLGSSELRKDIYITVHIIRI---GRMGAGEKKNACSVQYRRPFG--
CAVLSIADLLTGETKDDLILKVYMCNTESEWYQIHENIIKKLNARYNLTGSNAGLAVSLQ
LLHGDIE-QIRREYSSVFSHGVSITRKLGF

ENSGT00610000085806_3_Linker_1_3 (451, 456)

SNIIM

PF14429 // ENSGT00610000085806_3_Domain_3 (456, 652)

PGEMRNDLYITIERGEFEKGGKSVA
RNVEVTMFIVDSSGQTLKDFISFGSGE------PPASEYHSFVLYH--NNSPRWSELLKL
PIPVDKFRGAHIRFEFRHCSTKEK---GEKKLFGFSFVPLMQEDGRTLPDGTHELIVHKC
EENTNLQDTTRYLKLPFSKGI-FLGNNNQAMKATKESFCITSFLCSTKLTQ

ENSGT00610000085806_3_Linker_3_5 (652, 1250)

N---GDMLD
LLKWRTHP----------DKITGCLSKLKEIDGSEIVKFLQDTLDTLFGILDENSQKYGS
KVFDSLVHIINLLQDSKFHHFKPVMDTYIESHFAGA--LAYRDLIKVLKWYVDRITEAER
QEHIQEVLKAQEYIFKYIVQSRRLFSLATGGQNEEEFRCCIQELLMSVRFFLSQESKGSG
ALSQSQAVFLSSFPAVYSELLKLFDVREVANLVQDTLGSLPTILHVDDSLQAIKLQCIGK
TVE-SQLYTNPDSRYILLPVVLHHLHIHLQEQKDLIMCARILSNVFCLIKKNSSEKSVLE
EIDVIVASLLDILLRTILEITSRPQPSSSAMRFQFQDVTRTGFLNRESLHDSSTLSTFSF
CADTYGKVPMTGRH--------TGEFVACLLSLLRQMTDRHYQQLLDSFNTKEELRDFLL
QIFTV-----FRILIRP-----EMF-PKDWTVMRLVA---NN-VIITTVLYLSDALRKNF
LNENFDYKIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKYG-----DMRVTMGCEIF
SMWQNLGEHKLHFIPALIGPFLEVTLIPQPDLRNVMIPIFHDMM-----

PF06920 // ENSGT00610000085806_3_Domain_5 (1250, 1759)

-DWEQRRSGNF
KQVEAKLIDKLDSLMSEGKGDETYRELFNSIIPLFGP---YPSLLKKIERETWRESGVSL
IATVTRLMERLLDYRDCMKMGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHL
KAQNFTEAAYTLLLYDELLEWSDRPLREFLTYPMQTEWQRKEHLHLTIIQNFDRGKCWEN
GIILCRKIAEQYESYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLR
NKEFVCRGHDYERLEAFQQRMLNEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPIPES
QEVLQREGVPDNIKSFYKVNHIWKFRYDRPFHKGTKDKENEFKSLWVERTSLYLVQSLPG
ISRWFEVEKREVVEMSPLENAIEVLENKNQQLKTLISQCQTRQMQNINPLTMCLNGVIDA
AVNGGVSRYQEAFFVKEYILSHPEDGEKIARLRELMLEQ---AQILEFGLAVHEKFVPQD
MRPLHKKLVDQFFVMKSSLGIQEFSACMQASPVHFPNGSPRVCRNSAPASVSPDGTRVIP
RR---SPLSYPAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQ--------------
--------PSPSTSSLSSTHSASPNVTSSAPSSARASPLLSDKHKHSRENSCLSPRERPC
SAIYPTPVEPS-------------------------------------------------
-------QRMLFNHIGDG-ALPRSDPNLSAPEKAVNPTPSSWSLDSGKEAKNMSDSGKLI
SPPVPPRPTQTASPARHTTSV-SPSPAGRSPLK----------------GSVQSFTPSPV
EYH--SPGLISNSPVLSGSYSSGISSLSRCSTSETSGFENQVNEQSVPLPVPV-------
----PVPVPV-YGGEEPVRKESKTPPPYSVYERTLRRPVPLPHSLSIPV------TPEPP
ALPPKPLAARSSHLENG-ARRTDPGPRPRPLPRKVSQL-

------------------MWIPTEHEK

PF07653 // ENSGT00610000085806_3_Domain_0 (28, 82)

YGVVIASFRGTVPYGLSLEIGDTVQILEKCDGW
YRGFALKNPNIKGIFPSS--Y

ENSGT00610000085806_3_Linker_0_1 (82, 90)

VHLKNACV

PF16172 // ENSGT00610000085806_3_Domain_1 (90, 451)

KNKGQFEMVIPTEDSVITEMTSTLRDWGTMW
KQLYVRNEGDLFHRLWHIMNEILDLRRQVLVGHLTHDRMKDVKRHITARLDWGNEQLGLD
LVPRKEYAMVDPEDISVTELYRL---------------------------------MEHR
HRKKDTPVQASSHHLFVQMKSLMCSNLGEELEVIFSLFDSKENRPISERFFLRLNRNGLP
KAPDKPERHCSLFVDLGSSELRRDIYITVHIIRI---GRMGAGEKKNACSVQYRRPFG--
CAVLSIADLLTGETKDDLILKVYMCNTESEWYQIHENIIKKLNARYNLTGSNAGLAVSLQ
LLHGDIE-QIRREYSSVFSHGVSITRKLGF

ENSGT00610000085806_3_Linker_1_3 (451, 456)

SNIIM

PF14429 // ENSGT00610000085806_3_Domain_3 (456, 652)

PGEMRNDLYITIERGEFEKGGKSVA
RNVEVTMFIVESSGQILKDFISFGSGE------PPASEYHSFVLYH--NNSPRWSELLKL
PIPVDKFRGAHIRFEFRHCSTKEK---GEKKLFGFSFVPLMQEDGRTLPDGTHELIVHKC
EENTNLQDTTRYLKLPFSKGI-LLGNNNQAMKATKESFWITSFLCSTKLTQ

ENSGT00610000085806_3_Linker_3_5 (652, 1250)

N---GDMLD
LLKWRTHP----------DKITGCLSKLKEIDGSEIVKFLQDTLDTLFGILDENSQKYGS
KVFDSLVHIINLLQDSKFHHFKPVMDTYIESHFAGA--LAYRDLIKVLKWYVDRITEAER
QEHIQEVLKAQEYIFKYIVQSRRLFSLATGGQNEEEFRCCIQELLMSVRFFLSQESKGSG
ALSQSQAVFLSSFPAVYSELLKLFDVREVANLVQDTLGSLPTIVHVDDALQAVKLQCIGK
TVE-SQLYTNPDSRYILLPVVLHHLHMHLQEQKDLIMCARILSNVFCLIKKNSSEKSVLE
EIDVIVASLLDILLRTILEITSRPQPPGSTMRLQFQDV----------------------
----------------------TGEFVACLLSLLRQMTDRHYQQLLDSFNTKEELRDFLL
QIFTV-----FRILIRP-----EMF-PKDWTVMRLVA---NN-VIITTVLYLSDALRKNF
LNENFDYKIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKYG-----DMRVTMGCEIF
SMWQNLGEHKLHFIPALIGPFLEVTLIPQPDLRNVMIPIFHDMM-----

PF06920 // ENSGT00610000085806_3_Domain_5 (1250, 1759)

-DWEQRRSGNF
KQVEAKLIDKLDSLMSEGKGDETYRELFNSI------------LLKKIERETWRESGVSL
IATVTRLMERLLDYRDCMKVGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHL
KAQNFTEAAYTLLLYDELLEWSDRPLREFLTYPMQTEWQRKEHLHLAIIQNFDRGKCWEN
GIILCRKIAEQYESYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLR
NKEFVCRGHDYERLEAFQQRMLNEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPIPES
QEVLQREGVPDNIKSFYKVNHIWKFRYDRPFHKGTKDKENEFKSLWVERTSLYLVQSLPG
ISRWFEVEKREVVEMSPLENAIEVLENKNQQLKTLISQCQTRQMQNINPLTMCLNGVIDA
AVNGGVSRYQEAFFVKDYILSHPEDGEKIARLRELMLEQ---AQILEFGLAVHEKFVPQD
MRPLHKKLVDQFFVMKSSLGIQEFSACIQASPVHFPNGSPRVCRNSAPASMSPDGTRVIP
RR---SPLSYPAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQ--------------
--------PSPSTSSLSSTHSASPNVTSSAPSSARASPLLSDKHKHSRENSCLSPRERPC
SAIYPTPVEPS-------------------------------------------------
-------QRLLFNHIGDG-ALPRSDPNLSAPEKAVNPTPSSWSLDSGKEAKNMSDGGKLI
SPPVPPRPTQTASPARHTTSVSSPSPAGRSPLKRHQKQTQFKNISNQDLGSVQSFTPSPV
EYH--SPGLISNSPVLSGSYSSGISSLSRCSTSETSGFENQVNDPSAG--------PGL-
--------SY-SGPEEPVRKESKTPPPYSVYERTLRRPVPLPHSLSIPV------TAEPP
ALPPKPLAARSGHLENG-TRRTDPGPRPRPLPRKVSQL-

MLGTQGSMSPDGMSMLCT-VECHIHGILRRIIASFRGTVPYGLSLEIGDTVQILEKCDGW
YRGFALKNPNIKGIFPSS--YVHLKNACV

PF16172 // ENSGT00610000085806_3_Domain_1 (90, 451)

KNKGQFEMVIPTEDSVITEMTSTLRDWGTMW
KQLYVRNEGDLFHRLWHIMNEILDLRRQVLVGHLTHDRMKDVKRHITARLDWGNEQLGLD
LVPRKEYAMVDPEDISITELYRL---------------------------------MEHR
HRKKDTPVQASSHHLFVQMKSLMCSNLGEELEVIFSLFDSKENRPISERFFLRLNRNGLP
KAPDKPERHCSLFVDLGSSELRKDIYITVHIIRI---GRMGAGEKKNACSVQYRRPFG--
CAVLSIADLLTGETKDDLVLKVYMCNTESEWYQIHENIIKKLNARYNLTGSNAGLAVSLQ
LLHGDIE-QIRREYSSVFSHGVSITRKLGF

ENSGT00610000085806_3_Linker_1_3 (451, 456)

SDIIM

PF14429 // ENSGT00610000085806_3_Domain_3 (456, 652)

PGEMRNDLYITVERGEFEKGGKSVA
RNVEVTMFIVDSNGQPLKDFISFGSGE------PPASEYHSFVLYH--NNSPRWSELLKL
PIPVDKFRGSHIRFEFRHCSTKEK---GEKKLFGFSFVPLMQEDGRTLPDGTHELIVHKC
EENTNLQDTTRYLKLPFSKVI-FLGNNNQTMKATKESFWITSFLCSTKLTQ

ENSGT00610000085806_3_Linker_3_5 (652, 1250)

N---GDMLD
LLKWRTHP----------DKITGCLSKLKEIDGSEIVKFLQDTLDTLFGILDENSQKYGS
KVFDSLVHIINLLQDSKFHHFKPVMDTYIESHFAGA--LAYRDLIKVLKWYVDRITEAER
QEHIQEVLKAQEYIFKYIVQSRRLFSLATGGQNEEEFRCCIQELLMSVRFFLSQESKGTG
ALSQSQAVFLSSFPAVYSELLKLFDVREVANLVQDTLGSLPTIMHVDDSLQAIKLQCIGK
TVE-SQLYTNPDSRYILLPVVLHHLHIHLQEQKDLIMCARILSNVFCLIKKNSSEKSVLE
EIDVIVASLLDILLRTILEITSRPQASSSAMRLQFQDV----------------------
----------------------TGEFVACLLSLLRQMTDRHYQQLLNSFSTKEELRDFLL
QIFTV-----FRILIRP-----EMF-PKDWTVMRLVA---NN-VIITTVLYLSDALRKNF
LNENFDYKIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKYG-----DMRVTMGCEIF
SMWQNLGEHKLHFIPALIGPFLEVTLIPQPDLRNVMIPIFHDMM-----

PF06920 // ENSGT00610000085806_3_Domain_5 (1250, 1757)

-DWEQRRSGNF
KQVEAKLIDKLDSLMSEGKGDETYRELFNSIIPLFGP---YPSLLKKIERETWRESGVSL
IATVTRLMERLLDYRDCMKIGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHL
KAQNFTEAAYTLLLYDELLEWSDRPLREFLTYPMQTEWQRKEHLHLTIIQNFDRGKCWEN
GIILCRKIAEQYESYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLR
NKEFVCRGHDYERLEAFQQRMLNEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPIPES
QEVLQREGVPDNIKSFYKVNHIWKFRYDRPFHKGTKDKENEFKSLWVERTSLYLVQSLPG
ISRWFEVEKREVVEMSPLENAIEVLENKNQQLKTLISQCQTRQMQNINPLTMCLNGVIDA
AVNGGVSRYQEAFFVKDYILSHPEDGEKIARLRELMLEQ---AQILEFGLAVHEKFVPQD
MRPLHKKLVDQFFVMKSSFGIQEFPACIQASPVHFPNGSPRVCRNSAPASMSPDGTRVIP
RR---SPLSYPAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQ--------------
--------PSPSTSSLSSTHSASPNVTSSAPSSARASPLLSDKHKHSRENSCLSPRDRPC
SAIYPTPVEPS-------------------------------------------------
-------QRMLFNHIGDG-ALPRSDPNLSAPEKAVNPTPSSWSLDSGKEAKNMSDSGKLI
SPPVPPRPTQTASPARHTTSV-SPSPAGRSPLK----------------GSVQSFTPSPV
EYN--SPGLSSNSPVLSGSYSSGISSLSRCSTSETSGFENQANEQSVPV----PVPVPVP
--VPVPVPSF-SGSEEPVRKESKTPPPYSVYERTLRRPVPLPHSLSIPV------TSEPP
ALPPKPLAARSSHLENG-TRRTEPGPRPRPLPRKVSQL-

--------------------MY-QSYTRNVIIASFRGTVPFGLSLEIGDTVQILEKCDGW
YRGFALKNPNIKGIFPSS--YVHLKNACVKNKGKIIYTSEDWGW---NEG--

PF16172 // ENSGT00610000085806_3_Domain_1 (113, 319)

-DLFHRLW
HIMNE----------------ILDLRRQVLVGHLTHDRM---------KDVKRHITARLD
WGNEKEYAMVDPEDISITELY---------------------------------RLMEHR
HRKKDTPVQASSHHLFVQMKSLMCSNLGEELEVIFSLFDSKENRPIS-------------
------------------

ENSGT00610000085806_3_Linker_1_2 (319, 321)

SE

PF16172 // ENSGT00610000085806_3_Domain_2 (321, 408)

LRKDIYITVHIIRI---GRMGAGEKKNACSVQYRRPFG--
CAVLSIADLLTGETKDDLVLKVYMCNTESEWYQIHENIIKKLNARYN

ENSGT00610000085806_3_Linker_2_3 (408, 456)

LTGSNAGKNMGQ-
--------------------ALSPYTSLGFSNIIM

PF14429 // ENSGT00610000085806_3_Domain_3 (456, 652)

PGEMRNDLYITIERGEFEKGGKSVA
RNVEVTMFIVDSSGQTLKDFISFGAGE------PPASEYHSFVLYH--NNSPRWSELLKL
PIPVDKFRGAHIRFEFRHCSTKEK---GEKKLFGFSFVPLMQEDGRTLPDGTHELIVHKC
EENTNLQDTTRYLKLPFSKGI-FLGNNNQAMKATKESFWITSFLCSTKLTQ

ENSGT00610000085806_3_Linker_3_4 (652, 1250)

N---GNVQ-
YSQWREHL----------PD----------------------------------------
---KYEVHIINLLQDSKFHHFKPVMDTYIESHFAGA--LAYRDLIKVLKWYVDRITEAER
QEHIQEVLKAQEYIFKYIVQSRRLFSLATGGQNEEEFRCCIQELLMSVRFFLSQESKGSG
ALSQSQAVFLSSFPAVYSELLKLFDVREVANLVQDTLGSLPTIMHVDDSLQAIKLQCISK
TVE-SQLYTNPDSRYILLPVVLHHLHIHLQEQKDLIMCARILSNVFCLIKKNSSEKSVLE
EIDVIVTSLLDILLRTILEITSRPQPSSSALRLQFQDV----------------------
----------------------TGEFVACLLSLLRQMTDRHYQQLLDSFNTKEELRDFLL
QIFTV-----FRILIRPE------MFPKDWTVMRLVAN----NVIITTVLYLSDALRKNF
LNENFDYKIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKYG-----DMRVTMGCEIF
SMWQNLGEHKLHFIPALIGPFLEVTLIPQPDLRNVMIPIFHDMM-----

PF06920 // ENSGT00610000085806_3_Domain_4 (1250, 1464)

-DWEQRRSGNF
KQVEAKLIDKLDSLMSEGKGDETYRELFNSIIPLFGP---YPSLLKKIERETWRESGVSL
IATVTRLMERLLDYRDCMKMGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHL
KAQNFTEAAYTLLLYDELLEWSDRPLREFLTYPMQTEWQRKEHLHLTIIQNFDRGKCWEN
GIILCRKIAEQYESYYDYRNLSK

ENSGT00610000085806_3_Linker_4_5 (1464, 1498)

MRVRS-----------------------------

PF06920 // ENSGT00610000085806_3_Domain_5 (1498, 1759)

-LH
NKEFVCRGHDYERLEAFQQRMLTEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPIPES
QEVLQREGVPDNIKSFYKVNHIWKFRYDRPFHKGTKDKENEFKSLWVERTSLYLVQSLPG
ISRWFEVEKREVVEMSPLENAIEVLENKNQQLKTLISQCQTRQMQNINPLTMCLNGVIDA
AVNGGVSRYQEAFFVKEYILSHPEDGEKIARLRELMLEQ---AQILEFSLAVHEKFVPQD
MRPLHKKLVDQFFVMKSSLGIQEFSACMQASPVHFPNGSPRVCRNSAPASMSPDGTRVIP
RR---SPLSYPAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQLFVAHV--------
-----------------------PSLSVSIATVSFPSPLLSDKHKHSRENSCLSPRERPC
SAIYPTPGEPS-------------------------------------------------
-------QRMLFNHIGDG-ALPRSDPNLSAPDKAMNPTPSSWSLDXXXXXXXXSDSGKLI
SPPVPPRPTQTASPARHT-TTVSPSPAGRSPLKVQALVR-------------LKPEPDPG
SFFVLD-------PAQS--------HSPNCSSET-LKLR-------IG------------
-----------------LYTESRKXXFYNVIPRTFSV-----------------------
---------------------------------------

------------------------------

PF00018 // ENSGT00610000085806_3_Domain_0 (31, 85)

VIASFRGTVPYGLSLEIGDTVQILEKCDGW
YRGLALKNPNIKGIFPSS--YVHLKNACVKNKGXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXRNEGDLFHRLWHIMNEILDLRRQVLVGHLTHDRMKDVKRHITARLDWGNEQLGLD
LVPRKEYAMVDPEDISITELYRL---------------------------------MEHR
HRKKDTPVQASSHHLFVQMKSLMCSNLGEELEVIFSLFDSKENRPISERFFLRLNRNGLP
KAPDKPERHCSLFVDLGSSELRKDIYITVHIIRI---GRMGAGEKKNACSVQYRRPFG--
CAVLSIADLLTGETKDDLILKVYMCNTESEWYQIHENIIKKLNARYNLTGSNAGLAVSLQ
LFHGDIE-QIRREYSSVFSHGVSITRKLGFSNIIMPGEMRNDLYITIERGEFEKGGKSVA
RNVEVTMFIIDSGGQILKDFISFGSGE------PLASEYHSFVLYH--NNSPRWSELLKL
PIPVDKFRGAHIRFEFRHCSTKEK---GEKKLFGFSFVPLMQEDGRTLPDGTHELIVHKC
EENTNLQDITRYLKLPFSKGL-FLGNNNQAMKATKESFWITSFFCSTKLTQN---GDMLD
LLKWRTHP----------DKITGCLSKLKEIDGSEIVKFLQDTLDTLFGILDENSQKYGS
KVFDSLVHIINLLQDSKFHHFKPVMDTYIESHFAGALAYXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXAVFLSSFPAVYSELLKLFDIREVASLVQDTLGSLPTIMHVDDSLQAIKLQCIGK
TVE-SQLYTNPDSRYILLPVVLHHLHMHLQEQKDLIVCARILSNVFCLIKKNSSEKSVLE
EIDVIVASLLDILLRTILEITSRPQASGSTMRLQFQDVTIGSSKESLHGSIVSSFSVFTG
TYDRVPTM-----------CGHTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXDFLL
QIFTV-----FRILIRPE------MFPKDWTVMRLVAN----NVIITTVLYLSDALRKNF
LNENFDYKIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKYG-----DMRVTMGCEIF
SMWQNLGEHKLHFIPALIGPFLEVTLIPQPDLRNVMIPIFHDMM------DWEQRRSGNF
KQVEAKLIDKLDSLMSEGKGDETYRELFNSIIPLFGP---YPSLLKKIERETWRESGVSL
IATVTRLMERLLDYRDCMKMGEVDGKKIGCTVSLLXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXWQREEHLHLTIIQNFDRGKCWEN
GIILCRKIAEQYESYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLR
NKEFVCRGHDYERLEAFQQRMLNEFPHAIAMQHANQPDETIFQAEAQYAELYAVTPIPES
QVLQRS---VDNIKVYV--NHIN--RYDRV-----HKTKDENKSLWVERTSLYLVQSLPG
ISRWFEVEKREVVEMSPLENAIEVLENKNQQLKTLISQCQTRQMQNINPLTMCLNGVIDA
AVNGGVSRYQEAFFVKEYILSHPEDGEKIARLRELMLEQ---AQILEFGLAVHEKFVPQD
MRPLHKKLVDQFFVMKSSLGIQEFSACIQASPVHFPNGSPRVCRNSAPASMSPDGTRVIP
RR---SPLSYPAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQ--------------
--------PSPSTSSLSSTHSASPNVTSSAPSSARASPLLSDKHKHSRENSCLSPRERPC
SAIYPTPVEPS-------------------------------------------------
-------QRMLLNHIGDG--LPRSDPYLS-AEKAVNPTPSSWSLDSGKEAKNMSDSGKLI
SPPVPPRPTQTASPARHTTSV-SPSTAGRSPMK----------------GSVQSFTPSPV
EYH--SPGLTSNSPVLSGSYSSGISSLSRCSMSETSGFENQVNEHAAPV--------PVP
VPLPLPVPC-YSGPEEPARKESKTPPPYSVYERTLRRPVPLPHSLSIPV------TSEPP
ALPPKPLAARSSHLENG-TRRTDPGPRPRPLPRKVSQL-

--------------------------SWVGFIASFRGTVPYGLSLEIGDTVQILEKCDGW
YRGFALKNPNIKGIFPSS--YVHLKNACV

PF16172 // ENSGT00610000085806_3_Domain_1 (90, 451)

KNKGQFEMVIPTEDSVITEMTSTLRDWGTMW
KQLYVRNEGDLFHRLWHIMNEILDLRRQVLVGHLTHDRMKDVKRHITARLDWGNEQLGLD
LVPRKEYAMVDPEDISITELYRL---------------------------------MEHR
HRKKDTPVQASSHHLFVQMKSLMCSNLGEELEVIFSLFDSKENRPISERFFLRLNRNGLP
KAPDKPERHCSLFVDLGSSELRKDIYITVHIIRI---GRMGAGEKKNACSVQYRRPFG--
CAVLSIADLLTGETKDDLILKVYMCNTESEWYQIHENIIKKLNARYNLTGSNAGLAVSLQ
LLHGDIE-QIRREYSSVFSHGVSITRKLGF

ENSGT00610000085806_3_Linker_1_3 (451, 456)

SNIIM

PF14429 // ENSGT00610000085806_3_Domain_3 (456, 652)

PGEMRNDLYITIERGEFEKGGKSVA
RNVEVTMFIVDSSGQTLKDFISFGSGE------PPASEYHSFVLYH--NNSPRWSELLKL
PIPVDKFRGAHIRFEFRHCSTKEK---GEKKLFGFSFVPLMQEDGRTLPDGTHELIVHKC
EENTNLQDTTRYLKLPFSKGI-FLGNNNQAMKATKESFCITSFLCSTKLTQ

ENSGT00610000085806_3_Linker_3_5 (652, 1250)

N---GDMLD
LLKWRTHP----------DKITGCLSKLKEIDGSEIVKFLQDTLDTLFGILDENSQKYGS
KVFDSLVHIINLLQDSKFHHFKPVMDTYIESHFAGA--LAYRDLIKVLKWYVDRITEAER
QEHIQEVLKAQEYIFKYIVQSRRLFSLATGGQNEEEFRCCIQELLMSVRFFLSQESKGSG
ALSQSQAVFLSSFPAVYSELLKLFDVREVANLVQDTLGSLPTILHVDDSLQAIKLQCIGK
TVE-SQLYTNPDSRYILLPVVLHHLHIHLQEQKDLIMCARILSNVFCLIKKNSS------
EIDVIVASLLDILLRTILEITSRPQPSSSAMRFQFQDVTRTGFLNRESLHDSSTLSTFSF
CADTYGKVPMTGRH--------TGEFVACLLSLLRQMTDRHYQQLLDSFNTKEELRDFLL
QIFTV-----FRILIRP-----EMF-PKDWTVMRLVA---NN-VIITTVLYLSDALRKNF
LNENFDYKIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKYG-----DMRVTMGCEIF
SMWQNLGEHKLHFIPALIGPFLEVTLIPQPDLRNVMIPIFHDMM-----

PF06920 // ENSGT00610000085806_3_Domain_5 (1250, 1759)

-DWEQRRSGNF
KQVEAKLIDKLDSLMSEGKGDETYRELFNSIIPLFGP---YPSLLKKIERETWRESGVSL
IATVTRLMERLLDYRDCMKMGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHL
KAQNFTEAAYTLLLYDELLEWSDRPLREFLTYPMQTEWQRKEHLHLTIIQNFDRGKCWEN
GIILCRKIAEQYESYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLR
NKEFVCRGHDYERLEAFQQRMLNEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPIPES
QEVLQREGVPDNIKSFYKVNHIWKFRYDRPFHKGTKDKENEFKSLWVERTSLYLVQSLPG
ISRWFEVEKREVVEMSPLENAIEVLENKNQQLKTLISQCQTRQMQNINPLTMCLNGVIDA
AVNGGVSRYQEAFFVKEYILSHPEDGEKIARLRELMLEQ---AQILEFGLAVHEKFVPQD
MRPLHKKLVDQFFVMKSSLGIQEFSACMQASPVHFPNGSPRVCRNSAPASVSPDGTRVIP
RR---SPLSYPAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQ--------------
--------PSPSTSSLSSTHSASPNVTSSAPSSARASPLLSDKHKHSRENSCLSPRERPC
SAIYPTPVEPS-------------------------------------------------
-------QRMLFNHIGDG-ALPRSDPNLSAPEKAVNPTPSSWSLDSGKEAKNMSDSGKLI
SPPVPPRPTQTASPARHTTSV-SPSPAGRSPLK----------------GSVQSFTPSPV
EYH--SPGLISNSPVLSGSYSSGISSLSRCSTSETSGFENQVNEQSVPLPVPV-------
----PVPVPV-YGGEEPVRKESKTPPPYSVYERTLRRPVPLPHSLSIPV------TPEPP
ALPPKPLAARSSHLENG-ARRTDPGPRPRPLPRKVSQL-

------------------MWIPTEHEKYGVVIASFRGTVPFGLSLEIGDTVQILEKCDGW
YRGFALKNPNIKGIFPSS--YVHLKNACV

PF16172 // ENSGT00610000085806_3_Domain_1 (90, 451)

KNKGQFEMVIPTEDSVITEMTSTLRDWGTMW
KQLYVRNEGDLFHRLWHIMNEILDLRRQVLVGHLTHDRMKDVKRHITARLDWGNEQLGLD
LVPRKEYAMVDPEDISITELYRL---------------------------------MEHR
HRKKDTPVQASSHHLFVQMKSLMCSNLGEELEVIFSLFDSKENRPISERFFLRLNRNGLP
KAPEKPERHCSLFMDLGSSELRKDIYITVHIIRI---GRMGAGEKKNACSVQYRRPFG--
CAVLSIADLLTGETKDDLVLKVYMCNTESEWYQIHENIIKKLNARYNLTGSNAGLAVSLQ
LLHGDIE-QIRREYSSVFSHGVSITRKLGF

ENSGT00610000085806_3_Linker_1_3 (451, 456)

SNIIM

PF14429 // ENSGT00610000085806_3_Domain_3 (456, 652)

PGEMRNDLYITIERGEFEKGGKSVA
RNVEVTMFIVDSSGQTLKDFISFGAGE------PPASEYHSFVLYH--NNSPRWSELLKL
PIPVDKFRGAHIRFEFRHCSTKEK---GEKKLFGFSFVPLMQEDGRTLPDGTHELIVHKC
EENTNLQDTTRYLKLPFSKGI-FLGNNNQAMKATKESFWITSFLCSTKLTQ

ENSGT00610000085806_3_Linker_3_5 (652, 1250)

N---GDMLD
LLKWRTHP----------DKITGCLSKLKEIDGSEIVKFLQDTLDTLFGILDENSQKYGS
KVFDSLVHIINLLQDSKFHHFKPVMDTYIESHFAGA--LAYRDLIKVLKWYVDRITEAER
QEHIQEVLKAQEYIFKYIVQSRRLFSLATGGQNEEEFRCCIQELLMSVRFFLSQESKGSG
ALSQSQAVFLSSFPAVYSELLKLFDVREVANLVQDTLGSLPTIMHVDDSLQAIKLQCISK
TVE-SQLYTNPDSRYILLPVVLHHLHIHLQEQKDLIMCARILSNVFCLIKKNSSEKSVLE
EIDVIVTSLLDILLRTILEITSRPQPSSSALRLQFQDV----------------------
----------------------TGEFVACLLSLLRQMTDRHYQQLLDSFNTKEELRDFLL
QIFTV-----FRILIRP-----EMF-PKDWTVMRLVA---NN-VIITTVLYLSDALRKNF
LNENFDYKIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKYG-----DMRVTMGCEIF
SMWQNLGEHKLHFIPALIGPFLEVTLIPQPDLRNVMIPIFHDMM-----

PF06920 // ENSGT00610000085806_3_Domain_5 (1250, 1759)

-DWEQRRSGNF
KQVEAKLIDKLDSLMSEGKGDETYRELFNSIIPLFGP---YPSLLKKIERETWRESGVSL
IATVTRLMERLLDYRDCMKMGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHL
KAQNFTEAAYTLLLYDELLEWSDRPLREFLTYPMQTEWQRKEHLHLTIIQNFDRGKCWEN
GIILCRKIAEQYESYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLR
NKEFVCRGHDYERLEAFQQRMLTEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPIPES
QEVLQREGVPDNIKSFYKVNHIWKFRYDRPFHKGTKDKENEFKSLWVERTSLYLVQSLPG
ISRWFEVEKREVVEMSPLENAIEVLENKNQQLKTLISQCQTRQMQNINPLTMCLNGVIDA
AVNGGVSRYQEAFFVKEYILSHPEDGEKIARLRELMLEQ---AQILEFSLAVHEKFVPQD
MRPLHKKLVDQFFVMKSSLGIQEFSACMQASPVHFPNGSPRVCRNSAPASMSPDGTRVIP
RR---SPLSYPAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQ--------------
--------PSPSTSSLSSTHSASPNVTSSAPSSARASPLLSDKHKHSRENSCLSPRERPC
SAIYPTPGEPS-------------------------------------------------
-------QRMLFNHIGDG-ALPRSDPNLSAPDKAMNPTPSSWSLDSGKEAKNMSDSGKLI
SPPVPPRPTQTASPARHTTTV-SPSPAGRSPLK----------------SSVQSFTPSPV
EYH--SPGLTSNSPVLSGSYSSGISSLSRCSMSETSGFENQGNEPATPAP----------
------APGY-SAPEEPARKESKTPPPYSVFERTLRRPVPLPHSLSIPA------AAEPP
ALPPKPLAARAGHLENG-TRRTEPGPRPRPLPRKVSQL-

------------------------------

PF00018 // ENSGT00610000085806_3_Domain_0 (31, 85)

VIAGFRGTVPHGLSLEIGDTVQILEKCDGW
YRGFALKNPNIKGIFPSN--YIHLKNACVKNKGQFEMVIPTEDSVITEMTSTLRDWGTMW
KQLYVRNEGDLFHRLWHIMNEILDLRRQVLVGHLTHDRMKDVKRHITARLDWGNEQLGLD
LVPRKEYAMVDPEEISITELYRL---------------------------------MEHR
HRKKDTPVPASSHHLFVQMKSLMCSNLGEELEVIFSLFDSKENRPISERFFLRLNRNGLP
KCPEKPERHCSLFVDLSSSELRKDIYITVHIIRI---GRMGAGEKKNACNVQYRRPFG--
CAVLSIADLLAGDSKDDLILKVYMCNTESDWYQIHENIIKKLNARYNLTGSNAG------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------

--------------MWIP----TEHEK

PF07653 // ENSGT00610000085806_3_Domain_0 (28, 82)

YGVVIASFRGTVPYGLSLEIGDTVQILEKCDGW
YRGFALKNPNIKGIFPSS--Y

ENSGT00610000085806_3_Linker_0_1 (82, 90)

VHLKNACV

PF16172 // ENSGT00610000085806_3_Domain_1 (90, 451)

KNKGQFEMVIPTEDSVITEMTSTLRDWGTMW
KQLYVRNEGDLFHRLWHIMNEILDLRRQVLVGHLTHDRMKDVKRHITARLDWGNEQLGLD
LVPRKEYAMVDPEDISITELYRL---------------------------------MEHR
HRKKDTPVQASSHHLFVQMKSLMCSNLGEELEVIFSLFDSKENRPISERFFLRLNRNGLP
KAPDKPERHCSLFVDLGSSELRKDIYITVHIIRI---GRMGAGEKKNACSVQYRRPFG--
CAVLSIADLLTGETKDDLVLKVYMCNTESEWYQIHENIIKKLNARYNLTGSNAGLAVSLQ
LLHGDIE-QIRREYSSVFSHGVSITRKLGF

ENSGT00610000085806_3_Linker_1_3 (451, 456)

SNIIM

PF14429 // ENSGT00610000085806_3_Domain_3 (456, 652)

PGEMRNDLYITIERGEFEKGGKSVA
TNVEVTMFIVDSNGQNLKDFISFGAGE------PPATEYHSFVLYH--NNSPRWSELLKL
PIPVDKFRGSHIRFEFRHCSTKEK---GEKKLFGFSFVPLMQEDGRTLPDGTHELIVHKC
EENTNLQDTTRYLKLPFSKVI-FLGNNNQTMKATKESFWITSFLCSTKLTQ

ENSGT00610000085806_3_Linker_3_5 (652, 1250)

N---GDMLD
LLKWRTHP----------DKITGCLSKLKEIDGSEIVKFLQDTLDTLFGILDENSQKYGS
KVFDSLVHIINLLQDSKFHHFKPVMDTYIESHFAGA--LAYRDLIKVLKWYVDRITEAER
QEHIQEVLKAQEYIFKYIVQSRRLFSLATGGQNEEEFRCCIQELLMSVRFFLSQESKGSG
ALSQSQAVFLSSFPAVYSELLKLFDVREVANLVQDTLGSLPTIMHVDDSLQAIKLQCIGK
TVE-SQLYTNPDSRYILLPVVLHHLHIHLQEQKDLIMCARILSNVFCLIKKNSSEKSVLE
EIDVIVASLLDILLRTILEITSRPQASSSAMRLQFQDV----------------------
----------------------TGEFVACLLSLLRQMTDRHYQQLLDSFNTKEELRDFLL
QIFTV-----FRILIRP-----EMF-PKDWTVMRLVA---NN-VIITTVLYLSDALRKNF
LNENFDYKIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKYG-----DMRVTMGCEIF
SMWQNLGEHKLHFIPALIGPFLEVTLIPQPDLRNVMIPIFHDMM-----

PF06920 // ENSGT00610000085806_3_Domain_5 (1250, 1757)

-DWEQRRSGNF
KQVEAKLIDKLDSLMSEGKGDETYRELFNSIIPLFGP---YPSLLKKIERETWRESGVSL
IATVTRLMERLLDYRDCMKMGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHL
KAQNFTEAAYTLLLYDELLEWSDRPLREFLTYPMQTEWQRKEHLHLTIIQNFDRGKCWEN
GIILCRKIAEQYENYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLR
NKEFVCRGHDYERLEAFQQRMLNEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPIPES
QEVLQREGVPDNIKSFYKVNHIWKFRYDRPFHKGTKDKENEFKSLWVERTSLYLVQSLPG
ISRWFEVEKREVVEMSPLENAIEVLENKNQQLKTLISQCQTRQMQNINPLTMCLNGVIDA
AVNGGVSRYQEAFFVKEYILSHPEDGEKIARLRELMLEQ---AQILEFGLAVHEKFVPQD
MRPLHKKLVDQFFVMKSSFGIQEFSACIQASPVHFPNGSPRVCRNSAPASMSPDGTRVIP
RR---SPLSYPAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQ--------------
--------PSPSTSSLSSTHSASPNVTSSAPSSARASPLLSDKHKHSRENSCLSPRDRPC
SAIYPTPVEPS-------------------------------------------------
-------QRMLFNHIGDG-ALPRSDPNLSAPEKAVNPTPSSWSLDSGKEAKTMSDSGKLI
SPPVPPRPTQTASPARHTTSV-SPSPAGRSPMK----------------GSVQSFTPSPV
EYH--SPGLSSNSPVLSGSYSSGISSLSRCSTSETSGFENQVNEQSVPV----PMPV--P
--VPVPVPSF-SGPEEPVRKESKTPPPYSVYERTLRRPVPLPHSLSIPV------TSEPP
ALPPKPLAARSSHLENG-NRRTEPGPRPRPLPRKVSQL-

------------------------------V

PF07653 // ENSGT00610000085806_3_Domain_0 (32, 81)

IASFRGTVPYGLSLEIGDTVQILEKCDGW
YRGFALKNPNIKGIFPSS--YIHLKNACVKNKGQFEMVIPTEDSVITEMTSTLRDWGTMW
KQLYVRNEGDLFHRLWHIMNEILDLRRQVLVGHLTHDRMKDVKRHITARLDWGNEQLGLD
LVPRKEYAMVDPEDISITELYRLSLEDRQSN----------------SGLTVGVTQMEHR
HRKKDTPVQASSHHLFVQMKSLMCSNLGEELEVIFSLFDSKENRPIR-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------

------------------------------VIASFRGTVPYGLSLEIGDTVQILEKCDGW
YRGFALKNPNIKGIFPSS--YVHLKNACV

PF16172 // ENSGT00610000085806_3_Domain_1 (90, 451)

KNKGQFEMVIPTEDSVITEMTSTLRDWGTMW
KQLYVRNEGDLFHRLWHIMNEILDLRRQVLVGHLTHDRMKDVKRHITARLDWGNEQLGLD
LVPRKEYAMVDPEDISITELYRL---------------------------------MEHR
HRKKDTPVQASSHHLFVQMKSLMCSNLGEELEVIFSLFDSKENRPISERFFLRLNRNGLP
KAPDKPERHCSLFVDLGSTELRKDIYITVHIIRI---GRMGAGEKKNACSVQYRRPFG--
CAVLSIADLLTGETKDDLILKVYMCNTESEWYQIHENIIKKLNARYNLTGSNAGLAVSLQ
LLHGDIE-QIRREYSSVFSHGVSITRKLGF

ENSGT00610000085806_3_Linker_1_3 (451, 456)

SNIIM

PF14429 // ENSGT00610000085806_3_Domain_3 (456, 652)

PGEMRNDLYITIERGEFEKGGKSVA
RNVEVTMFIVDSSGQTLKDFISFGSGE------PPASEYHSFVLYH--NNSPRWSELLKL
PIPVDKFRGAHIRFEFRHCSTKEK---GEKKLFGFSFVPLMQEDGRTLPDGTHELIVHKC
EENTNLQDTTRYLKLPFSKGI-FLGNNNQAMKATKESFCITSFLCSTKLTQ

ENSGT00610000085806_3_Linker_3_5 (652, 1250)

N---GDMLD
LLKWRTHP----------DKITGCLSKLKEIDGSEIVKFLQDTLDTLFGILDENSQKYGS
KVFDSLVHIINLLQDSKFHHFKPVMDTYIESHFAGA--LLTF------------------
---KNCIFKAQEYIFKYIVQSRRLFSLATGGQNEEEFRCCIQELLMSVRFFLSQESKGSG
ALSQSQAVFLSSFPAVYSELLKLFDVREVANLVQDTLGSLPTILHVDDSLQAIKLQCIGK
TVE-SQLYTNPDSRYILLPVVLHHLHIHLQEQKDLIMCARILSNVFCLIKKNSSEKSVLE
EIDVIVASLLDILLRTILEITSRPQPSSSAMRFQFQDVTRTGFLNRESLHDNSTLSTFSF
CADTYGKVPMTGRR--------TGEFVACLLSLLRQMTDRHYQQLLDSFNTKEELRDFLL
QIFTV-----FRILIRP-----EMF-PKDWTVMRLVA---NN-VIITTVLYLSDALRKNF
LNENFDYKIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKYG-----DMRVTMGCEIF
SMWQNLGEHKLHFIPALIGPFLEVTLIPQPDLRNVMIPIFHDMM-----

PF06920 // ENSGT00610000085806_3_Domain_5 (1250, 1759)

-DWEQRRSGNF
KQVEAKLIDKLDSLMSEGKGDETYRELFNSIIPLFGP---YPSLLKKIERETWRESGVSL
IATVTRLMERLLDYRDCMKMGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHL
KAQNFTEAAYTLLLYDELLEWSDRPLREFLTYPMQTEWQRKEHLHLTIIQNFDRGKCWEN
GIILCRKIAEQYESYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLR
NKEFVCRGHDYERLEAFQQRMLNEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPIPES
QEVLQREGVPDNIKSFYKVNHIWKFRYDRPFHKGTKDKENEFKSLWVERTSLYLVQSLPG
ISRWFEVEKREVVEMSPLENAIEVLENKNQQLKTLISQCQTRQMQNINPLTMCLNGVIDA
AVNGGVSRYQEAFFVKEYILSHPEDGEKIARLRELMLEQ---AQILEFGLAVHEKFVPQD
MRPLHKKLVDQFFVMKSSLGIQEFSACMQASPVHFPNGSPRVCRNSAPASVSPDGTRVIP
RR---SPLSYPAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQ--------------
--------PSPSTSSLSSTHSASPNVTSSAPSSARASPLLSDKHKHSRENSCLSPRERPC
SAIYPTPVEPS-------------------------------------------------
-------QRMLFNHIGDG-ALPRSDPNLSAPEKAVNPTPSSWSLDSGKEAKNMSDSGKLI
SPPVPPRPTQTASPARHTTSV-SPSPAGRSPLK----------------GSVQSFTPSPV
EYH--SPGLISNSPVLSGSYSSGISSLSRCSTSETSGFENQVNEQSVPLPVPM-----P-
---VPVPVPS-YGGEEPVRKENKTPPPYSVYERTLRRPVPLPHSLSIPV------TPEPP
ALPPKPLAARSSHLENG-ARRTDPGPRPRPLPRKVSQL-

------------------MIAFIHSVSFFTVIASFRGTVPYGLSLEIGDTVQILEKCDGW
YRGFALKNPNIKGIFPSS--YVHLKNACV

PF16172 // ENSGT00610000085806_3_Domain_1 (90, 451)

KNKGQFEMVIPTEDSVITEMTSTLRDWGTMW
KQLYVRNEGDLFHRLWHIMNEILDLRRQVLVGHLTHDRMKDVKRHITARLDWGNEQLGLD
LVPRKEYAMVDPEDISITELYRL---------------------------------MEHR
HRKKDTPVQASSHHLFVQMKSLMCSNLGEELEVIFSLFDSKENRPISERFFLRLNRNGLP
KAPDKPERHCSLFVDLGSSELRKDIYITVHIIRI---GRMGAGEKKNACSVQYRRPFG--
CAVLSIADLLTGETKDDLILKVYMCNTESEWYQIHENIIKKLNARYNLTGSNAGLAVSLQ
LLHGDIE-QIRREYSSVFSHGVSITRKLGF

ENSGT00610000085806_3_Linker_1_3 (451, 456)

SNIIM

PF14429 // ENSGT00610000085806_3_Domain_3 (456, 652)

PGEMRNDLYITIERGEFEKGGKSVA
RNVEVTMFIVDSSGQALKDFISFGSGE------PPASEYHSFVLYH--NNSPRWSELLKL
PIPVDKFRGAHIRFEFRHCSTKEK---GEKKLFGFSFVPLMQEDGRTLPDGTHELIVHKC
EENTNLQDTTRYLKLPFSKGI-FLGNNNQAMKATKESFCITSFLCSTKLTQN---GDMLD
LLKWRTHP----------DKITGCLSKLKEIDGSEIVKFLQDTLDTLFGILDENSQKYGS
KVFDSLVHIINLLQDSKFHHFKPVMDTYIESHFAGA--LAYRDLIKVLKWYVDRITEAER
QEHIQEVLKAQEYIFKYIVQSRRLFSLATGGQNEEEFRCCIQELLMSVRFFLSQESKGSG
ALSQSQAVFLSSFPAVYSELLKLFDVREVANLVQDTLGSLPTILHVDDSLQAIKLQCIGK
TVE-SQLYTNPDSRYILLPVVLHHLHIHLQEQKDLIMCARILSNVFCLIKKNSSEKSVLE
EIDVIVTSLLDILLRTILEITSRPQPSSSAMRFQFQDV----------------------
----------------------TGEFVACLLSLLRQMTDRHYQQLLDSFNTKEELRDFLL
QIFTV-----FRILIRP-----EMF-PKDWTVMRLVA---NN-VIITTVLYLSDALRKNF
LNENFDYKIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKYG-----DMRVTMGCEIF
SMWQNLAGRGGGRLLRQESH---LNL-----------------------------GGGGC
KS-DSKKKKK--------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------MTDRHYQQLLDSFNTKEELRDFLL
QIFTV-----FRILIRPEM------FPKDWTVMRLVA----NNVIITTVLYLSDALRKNF
LNENFDYKIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKYG-----DMRVTMGCEIF
SMWQNLGEHKLHFIPALIGPFLEVTLIPQPDLRNVMIPIFHDMM------DWEQRRSGNF
KQVEAKLIDKLDSLMSEGKGDETYRELFNSIIPLFGP---YPSLLKKIERETWRESGVSL
IATVTRLMERLLDYRDCMKMGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHL
KAQNFTEAAYTLLLYDELLEWSDRPLREFLTYPMQTEWQRKEHLHLAIIQNFDRGKCWEN
GIILCRKIAEQYESYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLR
NKEFVCRGHDYERLEAFQQRMLNEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPIPES
QEVLQREGVPDNIK

PF06920 // ENSGT00610000085806_3_Domain_5 (1575, 1759)

SFYKVNHIWKFRYDRPFHKGTKDKENEFKSLWVERTSLYLVQSLPG
ISRWFEVEKREVVEMSPLENAIEVLENKNQQLKTLISQCQTRQMQNINPLTMCLNGVIDA
AVNGGVSRYQEAFFVKEYILSHPEDGEKIARLRELMLEQ---AQILEFGLAVHEKFVPQD
MRPLHKKLVDQFFVMKSSLGIQEFSACIQASPVHFPNGSPRVCRNSAPASMSPDGTRVIP
RR---SPLSYPAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQ--------------
--------PSPSTSSLSSTHSASPNVTSSAPSSARASPLLSDKHKHSRENSCLSPRERPC
SAIYPTPVEPS-------------------------------------------------
-------QRLLFNHIGDG-ALPRSDPNLSAPEKA--------------------------
------------SPARPTTPV-SPSPAGRSPLK----------------GSVQSFTPSPV
EYH--SPGLSSNSPVLSGSYSSGISSLSRCSTSETSGFENQVNDPSAPGPGPG-------
-------PCYSG-PEEPVRKESKTPPPYSVYERTLRRPVPLPHSLSIPVPP----TAEPP
ALPPKPLAARSSHLENG-TRRTDPAPRPRPLPRKVSQL-

----------------MDMIAFIYSVSFFTVIASFRGTVPYGLSLEIGDTVQILEKCDGW
YRGFALKNPNIKGIFPSS--YVHLKNACV

PF16172 // ENSGT00610000085806_3_Domain_1 (90, 451)

KNKGQFEMVIPTEDSVITEMTSTLRDWGTMW
KQLYVRNEGDLFHRLWHIMNEILDLRRQVLVGHLTHDRMKDVKRHITARLDWGNEQLGLD
LVPRKEYAMVDPEDISITELYRL---------------------------------MEHR
HRKKDTPVQASSHHLFVQMKSLMCSNLGEELEVIFSLFDSKENRPISERFFLRLNRNGLP
KAPDKPERHCSLFVDLGSSELRKDIYITVHIIRI---GRMGAGEKKNACSVQYRRPFG--
CAVLSIADLLTGETKDDLILKVYMCNTESEWYQIHENIIKKLNARYNLTGSNAGLAVSLQ
LLHGDIE-QIRREYSSVFSHGVSITRKLGF

ENSGT00610000085806_3_Linker_1_3 (451, 456)

SNIIM

PF14429 // ENSGT00610000085806_3_Domain_3 (456, 652)

PGEMRNDLYITIERGEFEKGGKSVA
RNVEVTMFIIDSSGQTLKDFISFGSGE------PPASEYHSFVLYH--NNSPRWSELLKL
PIPVDKFRGAHIRFEFRHCSTKEK---GEKKLFGFSFVPLMQEDGRTLPDGTHELIVHKC
EENTNLQDTTRYLKLPFSKGI-FLGNNNQAMKATKESFCITSFLCSTKLTQ

ENSGT00610000085806_3_Linker_3_5 (652, 1250)

N---GDMLD
LLKWRTHP----------DKITGCLSKLKEIDGSEIVKFLQDTLDTLFGILDENSQKYGS
KVFDSLVHIINLLQDSKFHHFKPVMDTYIESHFAGA--LAYRDLIKVLKWYVDRITEAER
QEHIQEVLKAQEYIFKYIVQSRRLFSLATGGQNEEEFRCCIQELLMSVRFFLSQESKGSG
ALSQSQAVFLSSFPAVYSELLKLFDVREVANLVQDTLGSLPTILHVDDSLQAIKLQCIGK
TVE-SQLYTNPDSRYILLPVVLHHLHIHLQEQKDLIMCARILSNVFCLIKKNSSEKSVLE
EIDVIVTSLLDILLRTILEITSRPQPSSSAMRFQFQDV----------------------
----------------------TGEFVACLLSLLRQMTDRHYQQLLDSFNSKEELRDFLL
QIFTV-----FRILIRP-----EMF-PKDWTVMRLVA---NN-VIITTVLYLSDALRKNF
LNENFDYKIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKYG-----DMRVTMGCEIF
SMWQNLGEHKLHFIPALIGPFLEVTLIPQPDLRNVMIPIFHDMM-----

PF06920 // ENSGT00610000085806_3_Domain_5 (1250, 1759)

-DWEQRRSGNF
KQVEAKLIDKLDSLMSEGKGDETYRELFNSIIPLFGP---YPSLLKKIERETWRESGVSL
IATVTRLMERLLDYRDCMKMGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHL
KAQNFTEAAYTLLLYDELLEWSDRPLREFLTYPMQTEWQRKEHLHLTIIQNFDRGKCWEN
GIILCRKIAEQYESYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLR
NKEFVCRGHDYERLEAFQQRMLNEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPIPES
QEVLQREGVPDNIKSFYKVNHIWKFRYDRPFHKGTKDKENEFKSLWVERTSLYLVQSLPG
ISRWFEVEKREVVEMSPLENAIEVLENKNQQLKTLISQCQTRQMQNINPLTMCLNGVIDA
AVNGGVSRYQEAFFVKEYILSHPEDGEKIARLRELMLEQ---AQILEFGLAVHEKFVPQD
MRPLHKKLVDQFFVMKSSLGIQEFSACMQASPIHFPNGSPRVCRNSAPASVSPDGTRVIP
RR---SPLSYPAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQ--------------
--------PSPSTSSLSSTHSASPNVTSSAPSSARASPLLSDKHKHSRENSCLSPRERPC
SAIYPTPVEPS-------------------------------------------------
-------QRMLFNHIGDG-ALPRSDPNLSAPEKAVNPTPSSWSLDSGKEAKNMSDSGKLI
SPPVPPRPTQTASPARHTTSI-SPSPAGRSPLK----------------GSVQSFTPSPV
EYH--SPGLISNSPVLSGSYSSGISSLSRCSTSETSGFENQVNEQSAPMPVPVPV---PV
--PVPVPVPT-YSGEEPVRKESKTPPPYSVYERTLRRPVPLPHSLSIPV------TSEPP
ALPPKPLAARSSHLENG-ARRTDPGPRPRPLPRKVSQL-

------MLLPIVLIFY---MPPVEYSAYFQFIASFRGTVPYGLSLEIGDTVQILEKCDGW
YRGFALKNPNIKGIFPSS--YVHLKNACV

PF16172 // ENSGT00610000085806_3_Domain_1 (90, 451)

KNKGQFEMVIPTEDSVITEMTSTLRDWGTMW
KQLYVRNEGDLFHRLWHIMNEILDLRRQVLVGHLTHDRMKDVKRHITARLDWGNEQLGLD
LVPRKEYAMVDPEDISITELYRL---------------------------------MEHR
HRKKDTPMQASSHHLFVQMKSLMCSNLGEELEVIFSLFDSKENRPISERFFLRLNRNGLP
KAPDKPERHCSLFVDLGSSDLRKDIYITVHIIRI---GRMGAGEKKNACSVQYRRPFG--
CAVLSIADLLTGETKDDLVLKVYMCNTESEWYQIHENIIKKLNARYNLTGSNAGLAVSLQ
LLHGDIE-QIRREYSSVFSHGVSITRKLGF

ENSGT00610000085806_3_Linker_1_3 (451, 456)

SNIIM

PF14429 // ENSGT00610000085806_3_Domain_3 (456, 652)

PGEMRNDLYITVERGEFEKGGKSVA
RNVEVTMFIVDSNGLPLKDFISFGSGE------PPASEYHSFVLYH--NNSPRWSELLKL
PIPVDKFRGSHIRFEFRHCSTKEK---GEKKLFGFSFVPLMQEDGRTLPDGTHELIVHKC
EENTNLQDTTRYLKLPFSKVI-FLGNNNQTMKATKESFWITSFLCSTKLTQ

ENSGT00610000085806_3_Linker_3_5 (652, 1250)

N---GDMLD
LLKWRTHP----------DKITGCLSKLKEIDGSEIVKFLQDTLDTLFGILDENSQKYGS
KVFDSLVHIINLLQDSKFHHFKPVMDTYIESHFAGA--LAYRDLIKVLKWYVDRITEAER
QEHIQEVLKAQEYIFKYIVQSRRLFSLATGGQNEEEFRCCIQELLMSVRFFLSQESKGAG
ALSQSQAVFLSSFPAVYSELLKLFDVREVANLVQDTLGSLPTIVHVDDSLQAIKLQCIGK
TVE-SQLYTNPDSRYILLPVVLHHLHIHLQEQKDLIMCARILSNVFCLIKKNSSEKSVLE
EIDVIVASLLDILLRTILEITSRPQATSSAMRLQFQDV----------------------
----------------------TGEFVACLLSLLRQMTDRHYQQLLNSFNTKEELRDFLL
QIFTV-----FRILIRP-----EMF-PKDWTVMRLVA---NN-VIITTVLYLSDALRKNF
LNENFDYKIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKYG-----DMRVTMGCEIF
SMWQNLGEHKLHFIPALIGPFLEVTLIPQPDLRNVMIPIFHDMM-----

PF06920 // ENSGT00610000085806_3_Domain_5 (1250, 1757)

-DWEQRRSGNF
KQVEAKLIDKLDSLMSEGKGDETYRELFNSIIPLFGP---YPSLLKKIERETWRESGVSL
IATVTRLMERLLDYRDCMKMGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHL
KAQNFTEAAYTLLLYDELLEWSDRPLREFLTYPMQTEWQRKEHLHLTIIQNFDRGKCWEN
GIILCRKIAEQYESYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLR
NKEFVCRGHDYERLEAFQQRMLNEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPIPES
QEVLQREGVPDNIKSFYKVNHIWKFRYDRPFHKGTKDKENEFKSLWVERTSLYLVQSLPG
ISRWFEVEKREVVEMSPLENAIEVLENKNQQLKALISQCQTRQMQNINPLTMCLNGVIDA
AVNGGVSRYQEAFFVKDYILSHPEDGEKIARLRELMLEQ---AQILEFGLAVHEKFVPQD
MRPLHKKLVDQFFVMKSSFGIQEFPACIQASPVHFPNGSPRVCRNSAPASMSPDGTRVIP
RR---SPLSYPAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQ--------------
--------PSPSTSSLSSTHSASPNVTSSAPSSARASPLLSDKHKHSRENSCLSPRDRPC
SAIYPTPVEPS-------------------------------------------------
-------QRTLFNHIGDG-ALPRSDPNLSAPEKAVNPTPSSWSLDSGKEAKNMSDGGKLI
SPPVPPRPTQTASPARHTTP-VSPSPVGRSPLK----------------GSVQSFTPSPV
EYN--SPGLSSNSPVLSGSYSSGISSLSRCSTSETSGFENQANEQSVAMPGPVP------
VSVPMPVPSF-SGSEEPVRKESKTPPPYSVYERTLRRPVPLPHSLSIPV------TSEPP
ALPPKPLAARSSHLENG-TRRTEPGPRPRPLPRKVSQL-

------------------MWIPTEHEK

PF07653 // ENSGT00610000085806_3_Domain_0 (28, 82)

YGVVIASFRGTVPYGLSLEIGDTVQILEKCDGW
YRGFALKNPNVKGIFPSS--YVHLKNACVKNKGQFEMVIPTEDSVITEMTSTLRDWGTMW
KQLYVRNEGDLFHRLWHIMNEILDLRRQVLVGHLTHDRMKDVKRHITARLDWGNEQLGLD
LVPRKEYAMVDPEDISITELYRL---------------------------------MEHR
HRKKDTPVQASNHHLFVQMKSLMCSNLGEELEVIFSLFDSKENRPISERFFLRLNRNGLP
KAPDKPERHCSLFVDLGSSELRRDVYITVHIIRI---GRMGAGEKKNACSTQYRRPFG--
CAVLSIADLLTGDTKDDLILKVYMCNTESEWYQIHENIIKKLNARYNLTGSNAGLAVSLQ
LLHGDIE-QIRREYSSVFSHGVSITRKLGFSNIIMPGEMRNDLYITIERGEFEKGGKSVA
RNVEVTMFIVESSGQILKDFISFGSGE------PPASEYHSFVLYH--NNSPRWSELLKL
PIPVDKFRGAHIRFEFRHCSTKEK---GEKKLFGFSFVPLMQEDGRTLPDGTHELIVHKC
EENTNLQDTTRYLKLPFSKGI-LLGNNHQAIKATKESFWITSFLCSTKLTQN---GDMLD
LLKWRTHP----------DKITGCLSKIKEIDGSEIVKFLQDTLDTLFGILDENSQKYGS
KVFDSLVHIINLLQDSKFHHFKPVMDTYIESHFAGA--LAYRDLIKVLKWYVDRITEAER
QEHIQEVLKAQEYIFKYIVQSRRLFSLATGGQNEEEFRCCIQELLMSVRFFLSQESKGSG
ALSQSQAVFLSSFPAVYSELLKLFDVREVANLVQDTLGSLPTIVHVDDSLQAVKLQCIGK
TVE-SQLYTNPDSRYILLPVVLHHLHMHLQEQKDLIMCARILSNVFCLIKKNSSEKSVLE
EIDVIVASLLDILLRTILEITSRPQPSGSAMRLQFQDV----------------------
----------------------TGEFVACLLSLLRQMTDRHYQQLLDSFNTKEELRDFLL
QIFTV-----FRILIRPE------MFPKDWTVMRLVA----NNVIITTVLYLSDALRKNF
LNENFDYKIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKYG-----DMRVTMGCEIF
SMWQNLGEHKLHFIPALIGPFLEVTLIPQADLRNVMIPIFHDMM------DWEQRRSGNF
KQVEAKLIDKLDSLMSEGKGDETYRELFNSIIPLFGP---YPSLLKKIERETWRESGVSL
IATVTRLMERLLDYRDCMKMGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHL
KAQNFTEAAYTLLLYDELLEWSDRPLREFLTYPMQTEWQRKEHLHLAIIQNFDRGKCWEN
GIVLCRKIAEQYESYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLR
NKEFVCRGHDYERLEAFQQRMLNEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPIPES
QEVLQREGVPDNIK

PF06920 // ENSGT00610000085806_3_Domain_5 (1575, 1759)

SFYKVNHIWKFRYDRPFHKGTKDKENEFKSLWVERTSLYLVQSLPG
ISRWFEVEKREVVEMSPLENAIEVLENKNQQLKTLISQCQTRQMQNINPLTMCLNGVIDA
AVNGGVSRYQEAFFVKEYILSHPEDGEKIARLRELMLEQ---AQILEFGLAVHEKFVPQD
MRPLHKKLVDQFFVMKSSLGIQEFSACIQASPVHFPNGSPRVCRNSAPASMSPDGTRVIP
RR---SPLSYPAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQ--------------
--------PSPSTSSLSSTHSASPNVTSSAPSSARASPLLSDKHKHSRENSCLSPRERPC
SAIYPTPVEPS-------------------------------------------------
-------QRLLFNHIGEG-ALPRSDPNLSAPEKAVNPTPSSWSLDSGKEAKNMSDSGKII
SPPVPPRPTQTASPARHTTSV-SPSPAGRSPLK----------------GSVQSFTPSPV
EYH--SPGLISNSPVLSGSYSSGISSLSRCSTSETSGFENQVNEQSAPG-----------
--------PSYSGSEEPGRKESKTPPPYSVYERTLRRPVPLPHSLSIPV------TAEPP
ALPPKPLAARPGHLENG-TRRTEPGPRPRPLPRKVSQL-

------------------MWIPTELEKYGVVIASFRGTIPHGLSLEIGDTVQILEKCDGW
YRGFALKNPNIKGIFPSS--YVHLKNACV

PF16172 // ENSGT00610000085806_3_Domain_1 (90, 451)

KNKGQFEMVIPTEDSVITEMTSTLRDWGTMW
KQLYVRNEGDLFHRLWHIMNEILDLRRQVLVGHLTHDRMKDIKRHITARLDWGNEQLGLD
LVPRKEYAMVDPEDISITELYRL---------------------------------MEHR
HRKKDTPVQASSHHLFVQMKSLMCSNLGEELEVIFSLFDSKENRPISERFFLRLNRNGLP
KAPDKPERHCSLFMDLGSSELRKDIYITVHIIRI---GRMGAGEKKNACSVQYRRPFG--
CAVLSIADLLTGETKDDLVLKVYMCNTESEWYQIHENIIKKLNARYNLTGSNAGLAVSLQ
LLHGDIE-QIRREYSSVFSHGVSITRKLGF

ENSGT00610000085806_3_Linker_1_3 (451, 456)

SNIIM

PF14429 // ENSGT00610000085806_3_Domain_3 (456, 652)

PGEMRNDLYITIERGEFEKGGKSVA
RNVEVTMFIVDSSGQTLKDFISFGSGE------PPASEYHSFVLYH--NNSPRWSELLKL
PIPVDKFRGAHIRFEFRHCSTKEK---GEKKLFGFSFVPLMQEDGRTLPDGTHELIVHKC
EENTNLQDTTRYLKLPFSKGI-FLGNNNQAMKATKESFWITSFLCSTKLTQ

ENSGT00610000085806_3_Linker_3_5 (652, 1250)

N---GDMLD
LLKWRTHP----------DKITGCLSKLKEIDGSEIVKFLQDTLDTLFGILDENSQKYGS
KVFDSLVHIINLLQDSKFHHFKPVMDTYIESHFAGA--LAYRDLIKVLKWYVDRITEAER
QEHIQEVLKAQEYIFKYIVQSRRLFSLATGGQNEEEFRCCIQELLMSVRFFLSQESKGSG
ALSQSQAVFLSSFPAVYSELLKLFDVREVANLVQDTLGSLPTIMHVDDSLQAIKLQCIGK
TVE-SQLYTNPDSRYILLPVVLHHLHIHLQEQKDLIMCARILSNVFCLIKKNSSEKSVLE
EIDVIVASLLDILLRTILEITSRPQPSSSAMRLQFQDV----------------------
----------------------TGEFVACLLSLLRQMTDRHYQQLLDSFNTKEELRDFLL
QIFTV-----FRILIRP-----EMF-PKDWTVMRLVA---NN-VIITTVLYLSDALRKNF
LNENFDYKIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKYG-----DMRVTMGCEIF
SMWQNLGEHKLHFIPALIGPFLEVTLIPQPDLRNVMIPIFHDMM-----

PF06920 // ENSGT00610000085806_3_Domain_5 (1250, 1759)

-DWEQRRSGNF
KQVEAKLIDKLDSLMSEGKGDETYRELFNSIIPLFGP---YPSLLKKIERETWRESGVSL
IATVTRLMERLLDYRDCMKMGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHL
KAQNFTEAAYTLLLYDELLEWSDRPLREFLTYPMQTEWQRKEHLHLTIIQNFDRGKCWEN
GIILCRKIAEQYESYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLR
NKEFVCRGHDYERLEAFQQRMLNEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPMPES
QEVLQREGVPDNIKSFYKVNHIWKFRYDRPFHKGTKDKENEFKSLWVERTSLYLVQSLPG
ISRWFEVEKREVVEMSPLENAIEVLENKNQQLKTLISQCQTRQMQNINPLTMCLNGVIDA
AVNGGVSRYQEAFFVKEYILSHPEDGEKIARLRELMLEQ---AQILEFGLAVHEKFVPQD
MRPLHKKLVDQFFVMKSSLGIQEFSACIQASPVHFPNGSPQVCRNSAPASMSPDGTRVIP
RR---SPLSYPAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQ--------------
--------PSPSTSSLSSTHSASPNVTSSAPSSARASPLLSDKHKHSRENSCLSPRERPC
SAIYPTPGEPS-------------------------------------------------
-------QRMLFNHIGDGGASPRSDPNLSAPEKAVNPTPSSWSLDSGKEAKNMSDSGKLI
SPPVPPRPTQTASPARHTTA-VSPSPAGRSPLK----------------GSVQSFTPSPV
EYH--SPGLTSNSPVLSGSYSSGISSLSRCSMSETSGFENQVNDQPAPATVP--------
--------G-YSGPEEPARKESKTPPPYSVYERTLRRPVPLPHSLSIPV------TPEPP
ALPPKPLAARAGHLENG-TRRTEPGPRPRPLPRKVSQL-

----------------------VWTEEEKYIIASFRGTVPYGLSLEIGDTVQILEKCDGE
WPGGL-----LEGIFPSS--YVHLKNACV

PF16172 // ENSGT00610000085806_3_Domain_1 (90, 451)

KNKGQFEMVIPTEDSVITEMTSTLRDWGTMW
KQLYVRNEGDLFHRLWHIMNEILDLRRQVLVGHLTHDRMKDVKRHITARLDWGNEQLGLD
LVPRKEYAMVDPEDISITELYRL---------------------------------MEHR
HRKKDTPVQASCHHLFVQMKSLMCSNLGEELEVIFSLFDSKENRPISERFFLRLNRNGLP
KAPDKPERHCSLFVDLGSSELRKDIYITVHIIRI---GRMGAGEKKNACSVQYRRPFG--
CAVLSIADLLAGETKDDLILKVYMCNTESEWYQIHENIIKKLNARYNLTGSNAGLAVSLQ
LLHGDIE-QIRREYSSVFSHGVSITRKLGF

ENSGT00610000085806_3_Linker_1_3 (451, 456)

SNIIM

PF14429 // ENSGT00610000085806_3_Domain_3 (456, 652)

PGEMRNDLYITIERGEFEKGGKSVA
RNVEVTMFIVDSSGLPLKDFISFGSGE------PPASEYHSFVLYH--NNSPRWSELLKL
PIPVDKFRGAHIRFEFRHCSTKEK---GEKKLFGFSFVPLMQEDGRTLPDGTHELIIHKC
EENTNLQDTTRYLKLPFSKGI-FLGNNNQAMKATKESFWITSFLCSTKLTQ

ENSGT00610000085806_3_Linker_3_5 (652, 1250)

N---GDMLD
LLKWRTHP----------DKITGCLSKLKEIDGSEIVKFLQDTLDTLFGILDENSQKYGS
KVFDSLVHIINLLQDSKFHHFKPVMDTYIESHFAGA--LAYRDLIKVLKWYVDRITEAER
QEHIQEVLKAQEYIFKYIVQSRRLFSLATGGQNEEEFRCCIQELLMSVRFFLSQESKGSR
ALSQSQAVFLSSFPAVYSELLKLFDVREVANLVQDTLGSLPTIMHVDDSLQAIKLQCIGK
TVE-SQLYTNPDSRYILLPVVLHHLHIHLQEQKDLIMCARILSNVFCLIKKNSSEKSVLE
EIDVIVASLLDILLRTILEITSRPQPSSSAMRLQFQDVTRRGSLNR----ESLYGDLTLS
T------------------FSVFGEFVACLLSLLRQMTDRHYQQLLDSFNTKEDLRDFLL
QIFTV-----FRILIRP-----EMF-PKDWTVMRLVA---NN-VIITTVLYLSDALRKNF
LNENFDYKIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKYG-----DMRVTMGCEIF
SMWQNLGEHKLHFIPALIGPFLEVTLIPQPDLRNVMIPIFHDMM-----

PF06920 // ENSGT00610000085806_3_Domain_5 (1250, 1759)

-DWEQRRSGNF
KQVEAKLIDKLDSLMSEGKGDETYRELFNSIIPLFGP---YPSLLKKIERETWRESGVSL
IATVTRLMERLLDYRDCMKMGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHL
KAQNFTEAAYTLLLYDELLEWSDRPLREFLTYPMQTEWQRKEHLHLTIIQNFDRGKCWEN
GIILCRKIAEQYESYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLR
NKEFVCRGHDYERLEAFQQRMLNEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPIPES
QEVLQREGVPDNIKSFYKVNHIWKFRYDRPFHKGTKDKENEFKVPCCLI------TC--C
PNRWVLV----SVEMSPLENAIEVLENKNQQLKTLISQCQTRQMQNINPLTMCLNGVIDA
AVNGGVSRYQEAFFVKEYILSHPEDGEKIARLRELMLEQ---AQILEFGLAVHEKFVPQD
MRPLHKKLVDQFFVMKSSLGIQEFSACIQASPVHFPNGSPRVCRNSAPASMSPDGTRVIP
RR---SPLSYPAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQ--------------
--------PSPSTSSLSSTHSASPNVTSSAPSSARASPLLSDKHKHSRENSCLSPRERPC
SAIYPTPVEPS-------------------------------------------------
-------QRMLFNHIGDG-ALPRSDPNLSAPEKAVNPTPSSWSLDSGKEAKNMSDSGKLI
SPPVPPRPTQTASPARHTTSV-SPSPAGRSPMK----------------GSVQSFTPSPV
EYH--SPGLTSNSPVLSGSYSSGISSLSRCSTSETSGFENQVNEQSAPG-----------
-----------PGPEEPVRKESKTPPPYSVYERTLRRPVPLPHSLSIPV------AAEPP
ALPPKPLAARSGHLENG-TRRTDPGPRPRPLPRKVSQL-

------------------PHRPKSSERQGVWELHFRGTIPYGLSLEIGDTVQILEKCDGW
YRGFALKNPNVKGIFPSS--FVHLKNACV

PF16172 // ENSGT00610000085806_3_Domain_1 (90, 451)

KNKGQFEMVIPTEDSVITEMTSTLRDWGTMW
KQLYVRNEGDLFHRLWHIMNEILDLRRQVLVGHLTHDRMKDVKRHITARLDWGNEQLGLD
LVPRKEYAMVDPEDISITELYRL---------------------------------MEHR
HRKKDTPVQASSHHLFVQMKSLMCSNLGEELEVIFSLFDSKENRPISERFFLRLNRNGLP
KAPDKPERHCSLFVDLGSSELRKDIYITVHIIRI---GRMGAGEKKNACSVQYRRPFG--
CAVLSIADLLTGDTKDDLVLKVYMCNTESEWYQIHENIIKKLNARYNLTGSNAGLAVSLQ
LLHGDIE-QIRREYSSVFSHGVSITRKLGF

ENSGT00610000085806_3_Linker_1_3 (451, 456)

SNIIM

PF14429 // ENSGT00610000085806_3_Domain_3 (456, 652)

PGEMRNDLYITIERGEFEKGGKSVA
RNVEVTMFIVDSNGQTLKDFISFGSGE------PAASEYHSFVLYH--NNSPRWSELLKL
PIPVDKFRGSHIRFEFRHCSTKEK---GEKKLFGFSFVPLMQEDGRTLPDGTHELIVHKC
EENTNLQDATRYLKLAFSKGI-FLGNNNQTMKATKESFWITSFLCSTKLTQ

ENSGT00610000085806_3_Linker_3_5 (652, 1250)

N---GDMLD
LLKWRTHP----------DKITGCLSKLKDIDGSEIVKFLQDTLDTLFGILDENSQKYGS
KVFDSLVHIINLLQDSKFHHFKPVMDTYIESHFAGA--LAYRDLIKVLKWYVDRITEAER
QEHIQEVLKAQEYIFKYIVQSRRLFSLATGGQNEEEFRCCIQELLMSVRFFLSQESKGSG
ALSQSQAVFLSSFPAVYSELLKLFDIREVANLVQDTLGSLPTFMHVDDSLQAIKLQCIGK
TVE-SQLYTNPDSRYILLPVVLHHLHSHLEEQKDLIMCARILSNVFCLIKKNSSEKSVLE
EIDVIVASLLDILLRTILEITSQPQASSSAMQLRFQDA----------------------
----------------------TGEFVACLLSLLRQMTDRHYQQLLDSFNTKEELRDFLL
QIFTV-----FRILIRP-----EMF-PKDWTVMRLVA---NN-VIITTVLYLSDALRKNF
LNENFDYKIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKYG-----DMRVTMGCEIF
SMWQNLGEHKLHFIPALIGPFLEVTLIPQPDLRNVMIPIFHDMM-----

PF06920 // ENSGT00610000085806_3_Domain_5 (1250, 1757)

-DWEQRRSGNF
KQVEAKLIDKLDSLMSEGKGDETYRELFNSIIPLFGP---YPSLLKKIERETWRESGVSL
IATVTRLMERLLDYRDCMKMGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHL
KAQNFTEAAYTLLLYDELLEWSDRPLREFLTYPTQTERQRKERLHLTIIQNFDRGKCWEN
GIILCRKIAEQYESYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLR
NKEFVCRGHDYERLEAFQQRMLNEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPIPES
QEVLQREGVPDNIKGFYKVNHIWKFRHDRPFHKGTKDKENEFKSLWVERTSLYLVQSLPG
ISRWFEVDKREVVEMSPLENAIEVLENKNQQLKTLISQCQTRQMQNINPLTMCLNGVIDA
AVNGGVSRYQEAFFVKEYILSHPEDGEKIARLRELMLEQ---AQILEFGLAVHEKFVPQD
MRPLHKKLVDQFFVMKSSFGVQEFSACIQASPIHFPNGSPRVCRNSAPASMSPDGTRVIS
RR---SPLSYPAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQ--------------
--------PSPSTSSLSSTHSASPNVTSSAPSSARGPSHMSTCTF---------SK----
-VLYV--------------------------------------------------NMCII
KTDSVPLQRMLFNHIGDG-ALPRSDPNLCAPEKAVNPTPSSWSLDSGKELKNMSDSGKLT
SPPVPPRPTQTASPARHTTSV-SPSPAGRSPLK----------------GSAQSFTPSPV
EYH--SPGLSSNSPVLSGSYSSGISSLSRCSTSETSGFENQVPVPMPMP-MPVPV-PAP-
--------SF-GGPEEPVRKESKTPPPYSVYERTLRRPVPLPHSLSIPI------AAEPP
ALPPKPLAARSSHLENG-TRRTEPGPRPRPLPRKVSQL-

------------------------------VIAGFRGTVPHGLSLEIGDTVQILEKCDGW
YRGFALKNPNLKGIFPSN--YIHLKNACVKNKGQFEMVIPTEDSVITEMTSTLRDWGTMW
KQLYVRNEGDLFHRLWHIMNEILDLRRQVLVGHLTHDRMKDVKRHITARLDWGNEQLGLD
LVPRKEYAMVDPEEISITELYRL---------------------------------MEHR
HRKKDTPVPASSHHLFVQMKSLMCSNLGEELEVIFSLFDSKENRPISERFFLRLNRNGLP
KCPEKPERHCSLFVDLGSSELRKDIYITVHIIRI---GRMGAGEKKNACNVQYRRPFG--
CAVLSIADLLAGDSKDDLVLKVYMCSTESDWYQIHENIIKKLNARYNLTGSNAGLAVSLQ
LLHGDIE-QIRREYTSRFTHGVSITRKLGFSNIIMPGEMRNDLYITVERGEFEKGGKSVA
RNVEVTMHVVDSSGQILKDFISFGSGE------PPASEYHSFVLYH--NNGPRWAELLKL
PIPVDKFRGAHIRCEFRHCSTKEK---GEKKLFGFSFVPLMQENGRTLPDGTHELIVHKC
EENANLQDSGRYLKLPFSKGI-SLGNNSQAVKTTKESFWITSFLCSTKLTQN---GDMLD
LLKWRTHP----------DKIAGCLSKLKEIDGSEIVKFLQDTLDTLFGILDENSQKYGS
KVFDCLVHIINLLQDSKFHHFKPVMDTYIESHFAGA--LAYRDLIKVLKWHIDRVTEVEL
HDHIQEVLKAQEYIFKYIVQSRRLFSIATGGQNEEEFRCCIQELLMSVRFFLSQESKGTS
ALSQLQAVFLSSFPSVYSELLKLFDVREVANLVHDALGSLPTVMHGDESLQAVKLQSIGK
TVE-SHLYTNPDSRCILLPVVLHHLHMHLQEQKDLIMCARILSNIFCLIKKNSSEKSVLE
EIDVIVNSLLDILLRTILEITSRPQPSGSAMRLQFQDV----------------------
----------------------TGEFVSCLLSLLRQMTDRHYQQLLDSFNTKEDLRDFLL
QIFTV-----FRILIRP-----EMF-PKDWTVMRLVA---NN-VIITTVLYLSDALRKNF
LNENFDYKIWDSYFFLAVIFINQLCLQLEMFTPSKKKKVLEKYG-----DMRVTMGCEIF
SMWQNLGEHKLHFIPALIGPFLEVTLIPQPDLRNVMIPIFHDMM------DWEQRRSGNF
KQVEAKLIDKLDSLMSEGKGDETYRELFNSIIPLFGP---YPSLLKKIERETWRESGVSL
IATVTRLMERLLDYRDCMKMGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHL
KAQNFTGSAYTLLLYDELLEWSDRPLREFLNYPMQTEWQRKECLHLTIIQNFDRGKCWEN
GIILCRKIAEQYESYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLR
NKEFVCRGHDYERLEAFQQRMLNEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPIPEN
QEVLQRDGIPDNIK

PF06920 // ENSGT00610000085806_3_Domain_5 (1575, 1759)

SFYKVNHIWRFRYDRPFHKGTKDKENEFKSLWVERTTLILVQSLPG
ISRWFEVEKREVVEMSPLENAIEVLENKNQQLRTLISQCQTRQMQNINPLTMCLNGVIDA
AVNGGVARYQEAFFVKEYILNHPEDGEKITRLRELTLEQ---AQILEFGLAVHEKVVPQD
MRPLHKKLVDQFFVMKSSLGIQEFSACVQASPVHFPNGSPRVCRNSIPVSMSPDAARVIP
RRR-NSPLSYPAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQ--------------
--------PSPSTSSLSSTHSASPNVTSSAPSSARASPLLSDKHKHSRENSCLSPRERPC
SAIYPTPLETS-------------------------------------------------
-------QRMLFNHIGDS-ALPRSDSNLPSSDKAVNTTPSSWSLDSGKEARNTSESGKLI
SPPVPPRPAQTASPARHIASI-SPSPAGRSPMK----------------GSVQSFTPSPV
EYH--SSGLISNSPALSGSYSSGISSLSRCSTSETSGFESQGSEPAV---------TVP-
--------SY-SISEEPVRKESKTPPPYSVYERTLKRPVPLPHSLSIPP------AADPP
ALPPKPQLVRPNNLENS-SRRTEQVPRPRPLPRKVSQL-

--------------------------SWVGFIASFRGTVPYGLSLEIGDTVQILEKCDGW
YRGFALKNPNIKGIFPSS--YVHLKNACV

PF16172 // ENSGT00610000085806_3_Domain_1 (90, 451)

KNKGQFEMVIPTEDSVITEMTSTLRDWGTMW
KQLYVRNEGDLFHRLWHIMNEILDLRRQVLVGHLTHDRMKDVKRHITARLDWGNEQLGLD
LVPRKEYAMVDPEDISITELYRL---------------------------------MEHR
HRKKDTPVQASSHHLFVQMKSLMCSNLGEELEVIFSLFDSKENRPISERFFLRLNRNGLP
KAPDKPERQCSLFVDLGSSELRKDIYITVHIIRI---GRMGAGEKKNACSVQYRRPFG--
CAVLSIADLLTGETKDDLILKVYMCNTESEWYQIHENIIKKLNARYNLTGSNAGLAVSLQ
LLHGDIE-QIRREYSSVFSHGVSITRKLGF

ENSGT00610000085806_3_Linker_1_3 (451, 456)

SNIIM

PF14429 // ENSGT00610000085806_3_Domain_3 (456, 652)

PGEMRNDLYITIERGEFEKGGKSVA
RNVEVTMFIVDSSGQTLKDFISFGSGE------PPASEYHSFVLYH--NNSPRWSELLKL
PIPVDKFRGAHIRFEFRHCSTKEK---GEKKLFGFSFVPLMQEDGRTLPDGTHELIVHKC
EENTNLQDTTRYLKLPFSKGI-FLGNNNQAMKATKESFCITSFLCSTKLTQ

ENSGT00610000085806_3_Linker_3_5 (652, 1250)

N---GDMLD
LLKWRTHP----------DKITGCLSKLKEIDGSEIVKFLQDTLDTLFGILDENSQKYGS
KVFDSLVHIINLLQDSKFHHFKPVMDTYIESHFAGA--LLTF------------------
---KNCIFKAQEYIFKYIVQSRRLFSLATGGQNEEEFRCCIQELLMSVRFFLSQESKGSG
ALSQSQAVFLSSFPAVYSELLKLFDVREVANLVQDTLGSLPTILHVDDSLQAIKLQCIGK
TVE-SQLYTNPDSRYILLPVVLHHLHIHLQEQKDLIMCARILSNVFCLIKKNSSEKSVLE
EIDVIVASLLDILLRTILEITSRPQPSSSAMRFQFQDVTRTGFLNRESLHDSSTLSTFSF
CADTYGKVPMTGRH--------TGEFVACLLSLLRQMTDRHYQQLLDSFNTKEELRDFLL
QIFTV-----FRILIRP-----EMF-PKDWTVMRLVA---NN-VIITTVLYLSDALRKNF
LNENFDYKIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKYG-----DMRVTMGCEIF
SMWQNLGEHKLHFIPALIGPFLEVTLIPQPDLRNVMIPIFHDMM-----

PF06920 // ENSGT00610000085806_3_Domain_5 (1250, 1759)

-DWEQRRSGNF
KQVEAKLIDKLDSLMSEGKGDETYRELFNSIIPLFGP---YPSLLKKIERETWRESGVSL
IATVTRLMERLLDYRDCMKMGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHL
KAQNFTEAAYTLLLYDELLEWSDRPLREFLTYPMQTEWQRKEHLHLTIIQNFDRGKCWEN
GIILCRKIAEQYESYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLR
NKEFVCRGHDYERLEAFQQRMLNEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPIPES
QEVLQREGVPDNIKSFYKVNHIWKFRYDRPFHKGTKDKENEFKSLWVERTSLYLVQSLPG
ISRWFEVEKREVVEMSPLENAIEVLENKNQQLKTLISQCQTRQMQNINPLTMCLNGVIDA
AVNGGVSRYQEAFFVKEYILSHPEDGEKIARLRELMLEQ---AQILEFGLAVHEKFVPQD
MRPLHKKLVDQFFVMKSSLGIQEFSACMQASPVHFPNGSPRVCRNSAPASVSPDGTRVIP
RR---SPLSYPAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQ--------------
--------PSPSTSSLSSTHSASPNVTSSAPSSARASPLLSDKHKHSRENSCLSPRERPC
SAIYPTPVEPS-------------------------------------------------
-------QRMLFNHIGDG-ALPRSDPNLSAPEKAVNPTPSSWSLDSGKEAKNMSDSGKLI
SPPVPPRPTQTASPARHTTSV-SPSPAGRSPLK----------------GSVQSFTPSPV
EYH--SPGLISNSPVLSGSYSSGISSLSRCSTSETSGFENQVNEQSVPLPVPV-------
----PVPVPV-YGGEEPVRKESKTPPPYSVYERTLRRPVPLPHSLSIPV------TPEPP
ALPPKPLAARSSHLENG-ARRTDPGPRPRPLPRKVSQL-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------GLAVSLQ
LLHGDIE-QIRREYSSVFTHGVSITRKLGFSNIIMPGEMRNDLYITIERGEFEKGGKSVA
RNVEVTMYIIDSNGQNLKDFISFGSGE------PPANEFHSFVLYH--NNSPRWSELLKL
PIPVDKFRGSHIRFEFRHCSTKEK---GEKKLFGFSFVPLMQEDGRTLPDGTHELIVHKC
EENTNLQDSSRYLRLPFSKAS-LLGTNNQAIKATKESFWITSFLCSTKLTQN---GDMLD
LLKWRTHP----------DKITGCLSKIKEIDGSEIVKFLQDTLDTLFGILDENSQKYGS
KVFDSLVHIINLLQDSKFHHFKPVMDTYIESHFAGA--LAYRDLIKVLKWYVDRITEAER
QEHIQEVLKAQEYIFKYIVQSRRLFSLATGGQNEEEFRCCIQELLMSVRFFLSQESKGSG
ALSQSQAVFLSSFPAVYSELLKLFDVREVANLVHDTLGSLPTIMHVDDSLQAVKLQCIGK
TVE-SQLYTNPDSRYILLPVVLHHLHMHLQEQKDLIMCARILSNIFCLIKKNSSEKSVLE
EIDVIVTSLLDILLRTILEITSRPQPSGSAMRLQFQDVTTKNSSNITASYTSLTISIPSL
---KHSNTVNIYWSSCHL-GEGVGGFISLIW---LLLTIRHIKQIIEFFQYVEEIHDFLL
QIFTV-----FRILIRPE------MFPKDWTVMRLVAN----NVIITTVLYLSDALRKNF
LNENFDYKIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKYG-----DMRVTMGCEIF
SMWQNLGEHKLHFIPALIGPFLEVTLIPQPDLRNVMIPIFHDMM------DWEQRRSGNF
KQVEAKLIDKLDSLMSEGKGDETYRELFNSIIPLFGP---YPSLLKKIERETWRESGVSL
IATVTRLMERLLDYRDCMKMGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHL
KAQNFTEAAYTLLLYDELLEWSDRPLREFLTYPMQTEWQRKEYLHLTIIQNFDRGKCWEN
GIILCRKIAEQYESYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLR
NKEFVCRGHDYERLEAFQQRMLNEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPIPES
QEVLQREGIPDNIK

PF06920 // ENSGT00610000085806_3_Domain_5 (1575, 1759)

SFYKVNHIWRFRYDRPFHKGTKDKENEFKSLWVERTSLILVQSLPG
ISRWFEVEKREVVEMSPLENAIEVLENKNQQLKTLISQCQTRQMQNINPLTMCLNGVIDA
AVNGGVSRYQEAFFVKEYILNHPEDGEKITRLRELMLEQ---AQILEFGLAVHEKFVPQD
MRPLHKKLVDQFFVMKSSLGIQEFSACIQASPVHFPNGSPRVCRNSAPASMSPDGARVIP
RR---SPLSYPAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQ--------------
--------PSPSTSSLSSTHSASPNVTSSAPSSARASPLLSDKHKHSRENSCLSPRERPC
SAIYPTPTEPS-------------------------------------------------
-------QRMLFNHIGDG-PLPRSDPNLSAPDKAVNPTPSSWSLDSGKEAKNMLDSGKLI
SPPVPPRPTQTASPARHG-TSVSPSPAGRSPMKGSMQS--------------FTPS--PV
EYH--SSGLISNSPVLSGSYSSGISSLSRCSTSETSGFENPVNEQTVSL-----------
--------STYSVPEEPVRKESKTPPPYSVYERTLRRPAPLPHSLSIPV------TSEPP
ALPPKPLLARSTNLEN-GSRRTEQVPRPRPLPRKVSQL-

------------------KWIGRYSIS

PF07653 // ENSGT00610000085806_3_Domain_0 (28, 84)

FLTVIASFRGTVPYGLSLEIGDTVQILEKCDGW
YRGFALKNPNIKGIFPSS--YVHLKNACVKNKGQFEMVIPTEDSVITEMTSTLRDWGTMW
KQLYVRNEGDLFHRLWHIMNEILDLRRQVLVGHLTHDRMKDVKRHITARLDWGNEQLGLD
LVPRKEYSMVDPEDISITELYRL---------------------------------MEHR
HRKKDTPVQASSHHLFVQMKSLMCSNLGEELEVIFSLFDSKENRPISERFFLRLNRNGLP
KAPDKPERHCSLFVDLGSSELRKDIYITVHIIRI---GRMAAGEKKNACSVQYRRPFG--
CAVLSIADLLTGETKDDLILKVYMCNTESEWYQIHENIIKKLNARYNLTGSNAGLAVSLQ
LLHGDIE-QIRREYSSVFSHGVSITRKLGFSNIIMPGEMRNDLYITIERGEFEKGGKSVA
RNVEVTMFIIDSSGQVLKEFISFGSGE------PPASEYHSFVLYH--NNSPRWSELLKL
PIPVDKFRGAHIRFEFRHCSTKEK---GEKKLFGFSFVPLMQEDGRTLPDGTHELIVHKC
EENTNLQDTTRYLKLPYSKGI-LLGNNNQAMKATKESFWITSFLCSTKLTQN---GDMLD
LLKWRTHP----------DKITGCLSKLKEIDGSEIVKFLQDTLDTLFGILDENSQKYGS
KVFDSLVHIINLLQDSKFHHFKPVMDTYIESHFAGA--LAYRDLIKVLKWYVDRITEAER
QEHIQEVLKAQEYIFKYIVQSRRLFSLATGGQNEEEFRCCIQELLMSVRFFLSRESKGSG
ALSQSQAVFLSSFPAVYSELLKLFDVREVANLVQDTLGSLPTIMHVDDSLQAVKLQCIGK
TVE-SQLYTNPDSRYILLPVVLHHLHMHLQEQKDLIMCARILSNVFCLIKKNSSEKSVLE
EIDVIVASLLDILLRTILEITSRPQSSGSAMRLQFQDV----------------------
----------------------TGEFVACLLSLLRQMTDRHYQQLLDSFSTKEDLRDFLL
QIFTV-----FRILIRP-----EMF-PKDWTVMRLVA---NN-VIITTVLYLSDALRKNF
LNENFDYKIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKYG-----DMRVTMGCEIF
SMWQNLGEHKLHFIPALIGPFLEVTLIPQPDLRNVMIPIFHDMM------DWEQRRSGNF
KQVEAKLIDKLDSLMSEGKGDETYRELFNSIIPLFGP---YPSLLKKIERETWRESGVSL
IATVTRLMERLLDYRDCMKMGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHL
KAQNFTEAAYTLLLYDELLEWSDRPLREFLTYPMQTEWQRKEHLHLTIIQNFDRGRCWEN
GIILCRKIAEQYESYYDYRNLSKMRMMEAALYDKIMDQQRLEPEFFRVGFYGKKFPFFLR
NKEFVCRGHDYERLEAFQQRMLNEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPIPES
QEVLQREGVPDNIKSFYKVNHIWKFRYDRPFHKGTKDKENEFKSLWVERTSLYLVQSLPG
ISRWFEVEKREVVEMSPLENATEVLENKNQQLKTLISQCQTRQMQNINPLTMCLNGVIDA
AVNGGVSRYQEAFFVKEYILSHPEDGEKIARLRELMLEQ---AQILEFGLAVHEKFVPQD
MRPLHKKLVDQFFVMKSSLGIQEFSACIQASPVHFPNGSPRVCRNSAPASMSPDGTRVIP
RRSQNSPLSYPAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQ--------------
--------PSPSTSSLSSTHSASPNVTSSAPSSARASPLLSDKHKHSRENSCLSPRERPC
SAIYPTPVEPS-------------------------------------------------
-------QRMLFNHIGDG-TLPRSDPNLSAPEKAVNPTPSSWSLDSGKEAKTMSDGGKLI
SPPVPPRPTLTASPARHTTPV-SPSPAGRSPLK----------------GSVQSFTPSPV
EYH--SPGLISNSPVLSGSYSSGISSLSRCSTSETSGFENQVNEQ------PASV-SVP-
--------SY-SGPEEPVRKESKTPPPYSVYERTLRRPVPLPHSLSIPV------TSEPP
ALPPKPVAARSSHLENG-TRRTEPGPRPRPLPRKVSQL-

------------------MIAFIYSVSFFTVIASFRGTVPYGLSLEIGDTVQILEKCDGW
YRGFALKNPNIKGIFPSS--YVHLKNACV

PF16172 // ENSGT00610000085806_3_Domain_1 (90, 451)

KNKGQFEMVIPTEDSVITEMTSTLRDWGTMW
KQLYVRNEGDLFHRLWHIMNEILDLRRQVLVGHLTHDRMKDVKRHITARLDWGNEQLGLD
LVPRKEYAMVDPEDISITELYRL---------------------------------MEHR
HRKKDTPVQASSHHLFVQMKSLMCSNLGEELEVIFSLFDSKENRPISERFFLRLNRNGLP
KAPDKPERHCSLFVDLGSSDLRKDIYITVHIIRI---GRMGAGEKKNACSVQYRRPFG--
CAVLSIADLLTGETKDDLILKVYMCNTESEWYQIHENIIKKLNARYNLTGSNAGLAVSLQ
LLHGDIE-QIRREYSSVFSHGVSITRKLGF

ENSGT00610000085806_3_Linker_1_3 (451, 456)

SNIIM

PF14429 // ENSGT00610000085806_3_Domain_3 (456, 652)

PGEMRNDLYITIERGEFEKGGKSVA
RNVEVTMFIVDSSGQTLKDFISFGSGE------PPASEYHSFVLYH--NNSPRWSELLKL
PIPVDKFRGAHIRFEFRHCSTKEK---GEKKLFGFSFVPLMQEDGRTLPDGTHELIVHKC
EENTNLQDTTRYLKLPFSKGI-FLGNNNQAMKATKESFCITSFLCSTKLTQ

ENSGT00610000085806_3_Linker_3_5 (652, 1250)

N---GDMLD
LLKWRTHP----------DKITGCLSKLKEIDGSEIVKFLQDTLDTLFGILDENSQKYGS
KVFDSLVHIINLLQDSKFHHFKPVMDTYIESHFAGA--LAYRDLIKVLKWYVDRITEAER
QEHIQEVLKAQEYIFKYIVQSRRLFSLATGGQNEEEFRCCIQELLMSVRFFLSQESKGSG
ALSQSQAVFLSSFPAVYSELLKLFDVREVANLVQDTLGSLPTILHVDDSLQAIKLQCIGK
TVE-SQLYTNPDSRYILLPVVLHHLHIHLQEQKDLIMCARILSNVFCLIKKNSSEKSVLE
EIDVIVTSLLDILLRTILEITSRPQPSSSAMRFQFQDV----------------------
----------------------TGEFVACLLSLLRQMTDRHYQQLLDSFSTKEELRDFLL
QIFTV-----FRILIRP-----EMF-PKDWTVMRLVA---NN-VIITTVLYLSDALRKNF
LNENFDYKIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKYG-----DMRVTMGCEIF
SMWQNLGEHKLHFIPALIGPFLEVTLIPQPDLRNVMIPIFHDMM-----

PF06920 // ENSGT00610000085806_3_Domain_5 (1250, 1759)

-DWEQRRSGNF
KQVEAKLIDKLDSLMSEGKGDETYRELFNSIIPLFGP---YPSLLKKIERETWRESGVSL
IATVTRLMERLLDYRDCMKMGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHL
KAQNFTEAAYTLLLYDELLEWSDRPLREFLTYPMQTEWQRKEHLHLTIIQNFDRGKCWEN
GIILCRKIAEQYESYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLR
NKEFVCRGHDYERLEAFQQRMLNEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPIPES
QEVLQREGVPDNIKSFYKVNHIWKFRYDRPFHKGTKDKENEFKSLWVERTSLYLVQSLPG
ISRWFEVEKREVVEMSPLENAIEVLENKNQQLKTLISQCQTRQMQNINPLTMCLNGVIDA
AVNGGVSRYQEAFFVKEYILSHPEDGEKIARLRELMLEQ---AQILEFGLAVHEKFVPQD
MRPLHKKLVDQFFVMKSSLGIQEFSACMQASPIHFPNGSPRVCRNSAPASVSPDGTRVIP
RR---SPLSYPAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQ--------------
--------PSPSTSSLSSTHSASPNVTSSAPSSARASPLLSDKHKHSRENACLSPRERPC
SAIYPTPVEPS-------------------------------------------------
-------QRMLFNHIGDG-ALPRSDPNLSAPEKAVNPTPSSWSLDSGKEAKNMSDSGKLI
SPPVPPRPTQTASPARHTTSI-SPSPAGRSPLK----------------GSVQSFTPSPV
EYH--SPGLISNSPVLSGSYSSGISSLSRCSTSETSGFENQVNEQSAPVPVPVPV-PVPV
--PVPVPVPT-YGGEEPVRKESKTPPPYSVYERTLRRPVPLPHSLSIPV------TPEPP
ALPPKPLAARSSHLENG-ARRTDPGPRPRPLPRKVSQL-

------------------MIVFIYSLSFFTVIASFRGTVPYGLSLEIGDTVQILEKCDGW
YRGFALKNPNIKGIFPST--YVHLKNACV

PF16172 // ENSGT00610000085806_3_Domain_1 (90, 451)

KNKGQFEMVIPTEDSVITEMTSTLRDWGTMW
KQLYVRNEGDLFHRLWHIMNEILDLRRQVLVGHLTHDRMKDVKRHITARLDWGNEQLGLD
LVPRKEYAMVDPEDISITELYRL---------------------------------MEHR
HRKKDTPVQASSHHLFVQMKSLMCSNLGEELEVIFSLFDSKENRPISERFFLRLNRNGLP
KAPDKPERHCSLFVDLGSSELRKDIYITVHIIRI---GRMGAGEKKNACSVQYRRPFG--
CAVLSIADLLTGETKDDLILKVYMCNTESEWYQIHENIIKKLNARYNLTGSNAGLAVSLQ
LLHGDIE-QIRREYSSVFSHGVSITRKLGF

ENSGT00610000085806_3_Linker_1_3 (451, 456)

SNIIM

PF14429 // ENSGT00610000085806_3_Domain_3 (456, 652)

PGEMRNDLYITIERGEFEKGGKSVA
RNVEVTMFIVDSSGQTLKDFISFGSGE------PPASEYHSFVLYH--NNSPRWSELLKL
PIPVDKFRGAHIRFEFRHCSTKEK---GEKKLFGFSFVPLMQEDGRTLPDGTHELIVHKC
EENTNLQDTTRYLKLPFSKGI-FLGNNNQAMKATKESFCITSFLCSTKLTQ

ENSGT00610000085806_3_Linker_3_5 (652, 1250)

N---GDMLD
LLKWRTHP----------DKITGCLSKLKEIDGSEIVKFLQDTLDTLFGILDENSQKYGS
KVFDSLVHIINLLQDSKFHHFKPVMDTYIESHFAGA--LAYRDLIKVLKWYVDRITEAER
QEHIQEVLKAQEYIFKYIVQSRRLFSLATGGQNEEEFRCCIQELLMSVRFFLSQESKGSG
ALSQSQAVFLSSFPAVYSELLKLFDVREVANLVQDTLGSLPTILHVDDSLQAIKLQCIGK
TVE-SQLYTNPDSRYILLPVVLHHLHIHLQEQKDLIMCARILSNVFCLIKKNSSEKSVLE
EIDVIVASLLDILLRTILEITSRPQPSSSAMRFQFQDVTRTGFLNRESSHGSTTLSTFSV
CADTYGKVPMTSRHTVSKRRSH---------------------------------NDFLL
QIFTV-----FRILIRP-----EMF-PKDWTVMRLVA---NN-VIITTVLYLSDALRKNF
LNENFDYKIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKYG-----DMRVTMGCEIF
SMWQNLGEHKLHFIPALIGPFLEVTLIPQPDLRNVMIPIFHDMM-----

PF06920 // ENSGT00610000085806_3_Domain_5 (1250, 1759)

-DWEQRRSGNF
KQVEAKLIDKLDSLMSEGKGDETYRELFNSIIPLFGP---YPSLLKKIERETWRESGVSL
IATVTRLMERLLDYRDCMKMGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHL
KAQNFTEAAYTLLLYDELLEWSDRPLREFLTYPMQTEWQRKEHLHLTIIQNFDRGKCWEN
GIILCRKIAEQYESYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLR
NKEFVCRGHDYERLEAFQQRMLNEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPIPES
QEVLQREGVPDNIKSFYKVNHIWKFRYDRPFHKGTKDKENEFKSLWVERTSLYLVQSLPG
ISRWFEVEKREVVEMSPLENAIEVLENKNQQLKTLISQCQTRQMQNINPLTMCLNGVIDA
AVNGGVSRYQEAFFVKEYILSHPEDGEKIARLRELMLEQ---AQILEFGLAVHEKFVPQD
MRPLHKKLVDQFFVMKSSLGIQEFSACMQASPVHFPNGSPRVCRNSAPASVSPDGTRVIP
RR---SPLSYPAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQ--------------
--------PSPSTSSLSSTHSASPNVTSSAPSSARASPLLSDKHKHSRENSCLSPRERPC
SAIYPTPVEPS-------------------------------------------------
-------QRMLFNHIGDG-ALPRSDPNLSAPEKAVNPTPSSWSLDSGKEAKNMSDSGKLI
SPPVPPRPTQTASPARHTASV-SPSPAGRSPLK----------------GSVQSFTPSPV
EYH--SPGLISNSPVLSGSYSSGISSLSRCSTSETSGFENQVNEQSAPLPVPV-------
----PVPVPS-YGGEEPVRKESKTPPPYSVYERTLRRPVPLPHSLSIPV------TSEPP
ALPPKPLAARSSHLENG-ARRTDPGPRPRPLPRKVSQL-

--------------TWL---SSYVLCPF

PF07653 // ENSGT00610000085806_3_Domain_0 (29, 82)

FTVIASFRGTVPYGLSLEIGDTVQILEKCDGW
YRGFALKNPNIKGIFPSS--YVHLKNACVKNKGQFEMVIPTEDSVITEMTSTLRDWGTMW
KQLYVRNEGDLFHRLWHIMNEILDLRRQVLVGHLTHDRMKDVKRHITARLDWGNEQLGLD
LVPRKEYAMVDPEDISITELYRL---------------------------------MEHR
HRKKDTPVQASSHHLFVQMKSLMCSNLGEELEVIFSLFDSKENRPISERFFLRLNRNGLP
KAPDKPERHCSLFVDLGSSELRKDIYITVHIIRI---GRMGAGEKKNACSVQYRRPFG--
CAVLSIADLLTGETKDDLILKVYMCNTESEWYQIHENIIKKLNARYNLTGSNAGLAVSLQ
LLHGDIE-QIRREYSSVFSHGVSITRKLGFSNIIMPGEMRNDLYITIERGEFEKGGKSVA
RNVEVTMFIIDSNGQTLKDFISFGSGE------PPASDYHSFVLYH--NNSPRWSELLKL
PIPVDKFRGAHVRFEFRHCSTKEK---GEKKLFGFSFVPLMQEDGRTLPDGTHELIVHKC
EENTNLQDTTRYLKLPFSKGIIILGNNNQAMKATKESFWITSFLCSTKLTQN---GDMLD
LLKWRTHP----------DKITGCLSKLKEIDGSEIVKFLQDTLDTLFGILDENSQKYGS
KVFDSLVHIINLLQDSKFHHFKPVMDTYIESHFAGA--LAYRDLIKVLKWYVDRITEADR
QEHIQEVLKAQEYIFKYIVQSRRLFSLATGGQNEEEFRCCIQELLMSVRFFLSQESKGSR
ALSQSQAVFLSSFPAVYSELLKLFDVREVANLVQDTLGSLPTIMHVDDSLQAIKLQCIGK
TVE-SQLYTNPDSRYILLPVVLHHLHIHLQEQKDLIVCARILSNVFCLIKKNSSEKSVLE
EIDVIVASLLDILLRTILEITSRPQPSSSAMRLQFQDVTSSDIDSGHSQKQFSWGTDDL-
--SDFSIICSQRTGSLNQESSYTGEFVACLLSLLRQMTDRHYQQLLDSFNTKEDLRDFLL
QIFTV-----FRILIRP-----EMF-PKDWTVMRLVA---NNSVIITTVLYLSDALRKNF
LNENFDYKIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKYG-----DMRVTMGCEIF
SMWQNLGEHKLHFIPALIGPFLEVTLIPQADLRNVMIPIFHDMM------DWEQRRSGNF
KQVEAKLIDKLDSLMSEGKGDETYRELFNSIIPLFGP---YPSLLKKIERETWRESGVSL
IATVTRLMERLLDYRDCMKMGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHL
KAQNFTEAAYTLLLYDELLEWSDRPLREFLTYPMQTEWQRKEHLHLTIIQNFDRGKCWEN
GIILCRKIAEQYESYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLR
NKEFVCRGHDYERLEAFQQRMLNEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPIPES
QEVLQREGVPDNIK

PF06920 // ENSGT00610000085806_3_Domain_5 (1575, 1759)

SFYKVNHIWKFRYDRPFHKGTKDKENEFKSLWVERTSLYLVQSLPG
ISRWFEVEKREVIEMSPLENAIEVLENKNQQLKTLITQCQTRQMQNINPLTMCLNGVIDA
AVNGGVSRYQEAFFIKEYILTHPEDGEKIARLRELMLEQ---AQILEFGLAVHEKFVPQD
MRPLHKKLVDQFFVMKSSLGIQEFSACIQASPVHFPNGSPRVCRNSAPASMSPDGTRVIP
RR---SPLSYPAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQ--------------
--------PSPSTSSLSSTHSASPNVTSSAPSSARASPLLSDKHKHSRENACLSPRERPC
SAIYPTPVEPS-------------------------------------------------
-------QRMLFNHIGDG-ALPRSDPNLSAPEKAVNPTPSSWSLDSGKEAKNMSDSGKLI
SPPVPPRPTQTASPARHTTSV-SPSPAGRSPLK----------------GSVQSFTPSPV
EYH--SPGLISNSPVLSGSYSSGISSLSRCSTSETSGFENQVNEQSAAAPGS--------
------V-PG-CGPEEPVRKESKTPPPYSVYERTLRRPVPLPHSLSIPV------AAEPP
ALPPKPLAARSSHLENG-NRRTDPGPRPRPLPRKVSQL-

------------------MTVFIYSLSFFTVIASFRGTVPYGLSLEIGDTVQILEKCDGW
YRGFALKTPNIKGIFPSS--YVHLKNACV

PF16172 // ENSGT00610000085806_3_Domain_1 (90, 451)

KNKGQFEMVIPTEDSVITEMTSTLRDWGTMW
KQLYVRNEGDLFHRLWHIMNEILDLRRQVLVGHLTHDRMKDVKRHITARLDWGNEQLGLD
LVPRKEYAMVDPEDISITELYRL---------------------------------MEHR
HRKKDTPVQASSHHLFVQMKSLMCSNLGEELEVIFSLFDSKENRPISERFFLRLNRNGLP
KAPDKPERHCSLFVDLGSSELRKDIYITVHIIRI---GRMGAGEKKNACSVQYRRPFG--
CAVLSIADLLTGETKDDLILKVYMCNTESEWYQIHENIIKKLNARYNLTGSNAGLAVSLQ
LLHGDIE-QIRREYSSVFSHGVSITRKLGF

ENSGT00610000085806_3_Linker_1_3 (451, 456)

SNIIM

PF14429 // ENSGT00610000085806_3_Domain_3 (456, 652)

PGEMRNDLYITIERGEFEKGGKSVA
RNVEVTMFIVDSSGQTLKDFISFGSGE------PPASEYHSFVLYH--NNSPRWSELLKL
PIPVDKFRGAHIRFEFRHCSTKEK---GEKKLFGFSFVPLMQEDGRTLPDGTHELIVHKC
EENTNLQDTARYLKLPFSKGI-FLGNNNQAMKATKESFCITSFLCSTKLTQ

ENSGT00610000085806_3_Linker_3_5 (652, 1250)

N---GDMLD
LLKWRTHP----------DKITGCLSKLKEIDGSEIVKFLQDTLDTLFGILDENSQKYGS
KVFDSLVHIINLLQDSKFHHFKPVMDTYIESHFAGA--LAYRDLIKVLKWYVDRITEAER
QEHIQEVLKAQEYIFKYIVQSRRLFSLATGGQNEEEFRCCIQELLMSVRFFLSQESKGSG
ALSQSQAVFLSSFPAVYSELLKLFDVREVANLVQDTLGSLPTILHVDDSLQAIKLQCIGK
TVE-SQLYTNPDSRYILLPVVLHHLHIHLQEQKDLIMCARILSNVFCLIKKNSSEKSVLE
EIDVIVASLLDILLRTILEITSRPQPSSSAMRFQFQDVTRTGFLNRESLHGSTTLSTFSV
CADTYGKVPMTSRHTMSKHRSHNGEFVACLLSLLRQMTDRHYQQLLDSFNTKEELRDFLL
QIFTV-----FRILIRP-----EMF-PKDWTVMRLVA---NN-VIITTVLYLSDALRKNF
LNENFDYKIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKYG-----DMRVTMGCEIF
SMWQNLGEHKLHFIPALIGPFLEVTLIPQPDLRNVMIPIFHDMM-----

PF06920 // ENSGT00610000085806_3_Domain_5 (1250, 1759)

-DWEQRRSGNF
KQVEAKLIDKLDSLMSEGKGDETYRELFNSIIPLFGP---YPSLLKKIERETWRESGVSL
IATVTRLMERLLDYRDCMKMGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHL
KAQNFTEAAYTLLLYDELLEWSDRPLREFLTYPMQTEWQRKEHLHLTIIQNFDRGKCWEN
GIILCRKIAEQYESYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLR
NKEFVCRGHDYERLEAFQQRMLNEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPIPES
QEVLQREGVPDNIKSFYKVNHIWKFRYDRPFHKGTKDKENEFKSLWVERTSLYLVQSLPG
ISRWFEVEKREVVEMSPLENAIEVLENKNQQLKTLISQCQTRQMQNINPLTMCLNGVIDA
AVNGGVSRYQEAFFVKEYILSHPEDGEKIARLRELMLEQ---AQILEFGLAVHEKFVPQD
MRPLHKKLVDQFFVMKSSLGIQEFSACMQASPVHFPNGSPRVCRNSAPASVSPDGTRVIP
RR---SPLSYPAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQ--------------
--------PSPSTSSLSSTHSASPNVTSSAPSSARASPLLSDKHKHSRENSCLSPRERPC
SAIYPTPVEPS-------------------------------------------------
-------QRMLFNHIGDG-ALPRSDPNLSAPEKAVNPTPSSWSLDSGKEAKNMSDSGKLI
SPPVPPRPTQTASPARHTTSV-SPSPAGRSPLK----------------GSVQSFTPSPV
EYH--SPGLISNSPVLSGSYSSGISSLSRCSTSETSGFENQVNEQSAPLPVPV-------
----PVPVPV-YSGEEPVRKESKTPPPYSVYERTLRRPVPLPHSLSIPV------TPEPP
ALPPKPLAARSMHLENG-ARRTDPGPRPRPLPRKVSQL-

------------------MIVFIYSLSFFTVIASFRGTVPYGLSLEIGDTVQILEKCDGW
YRGFALKNPNIKGIFPSS--YVHLKNACV

PF16172 // ENSGT00610000085806_3_Domain_1 (90, 451)

KNKGQFEMVIPTEDSVITEMTSTLRDWGTMW
KQLYVRNEGDLFHRLWHIMNEILDLRRQVLVGHLTHDRMKDVKRHITARLDWGNEQLGLD
LVPRKEYAMVDPEDISITELYRL---------------------------------MEHR
HQKKDTPVQASSHHLFVQMKSLMCSNLGEELEVIFSLFDSKENRPISERFFLRLNRNGLP
KAPDKPERHCSLFVDLGSSELRKDIYITVHIIRI---GRMGAGEKKNACSVQYRRPFG--
CAVLSIADLLTGETKDDLILKVYMCNTESEWYQIHENIIKKLNARYNLTGSNAGLAVSLQ
LLHGDIE-QIRREYSSVFSHGVSITRKLGF

ENSGT00610000085806_3_Linker_1_3 (451, 456)

SNIIM

PF14429 // ENSGT00610000085806_3_Domain_3 (456, 652)

PGEMRNDLYITIERGEFEKGGKSVA
RNVEVTMFIVDSSGQTLKDFISFGSGE------PPASEYHSFVLYH--NNSPRWSELLKL
PIPVDKFRGAHIRFEFRHCSTKEK---GEKKLFGFSFVPLMQEDGRTLPDGTHELIVHKC
EENTNLQDTTRYLKLPFSKGI-FLGNNNQAMKATKESFCITSFLCSTKLTQ

ENSGT00610000085806_3_Linker_3_5 (652, 1250)

N---GDMLD
LLKWRTHP----------DKITGCLSKLKEIDGSEIVKFLQDTLDTLFGILDENSQKYGS
KVFDSLVHIINLLQDSKFHHFKPVMDTYIESHFAGA--LAYRDLIKVLKWYVDRITEAER
QEHIQEVLKAQEYIFKYIVQSRRLFSLATGGQNEEEFRCCIQELLMSVRFFLSQESKGSG
ALSQSQAVFLSSFPAVYSELLKLFDVREVANLVQDTLGSLPTILHVDDSLQAIKLQCIGK
TVE-SQLYTNPDSRYILLPVVLHHLHIHLQEQKDLIMCARILSNVFCLIKKNSSEKSVLE
EIDVIVASLLDILLRTILEITSRPQPSSSAMRFQFQDVTRTGFLNRESSHGSTTLSTFSV
CADTYGKVPMTSRH--------TGEFVACLLSLLRQMTDRHYQQLLDSFNTKEELRDFLL
QIFTV-----FRILIRP-----EMF-PKDWTVMRLVA---NN-VIITTVLYLSDALRKNF
LNENFDYKIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKYG-----DMRVTMGCEIF
SMWQNLGEHKLHFIPALIGPFLEVTLIPQPDLRNVMIPIFHDMM-----

PF06920 // ENSGT00610000085806_3_Domain_5 (1250, 1759)

-DWEQRRSGNF
KQVEAKLIDKLDSLMSEGKGDETYRELFNSIIPLFGP---YPSLLKKIERETWRESGVSL
IATVTRLMERLLDYRDCMKMGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHL
KAQNFTEAAYTLLLYDELLEWSDRPLREFLTYPMQTEWQRKEHLHLTIIQNFDRGKCWEN
GIILCRKIAEQYESYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLR
NKEFVCRGHDYERLEAFQQRMLNEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPIPES
QEVLQREGVPDNIKSFYKVNHIWKFRYDRPFHKGTKDKENEFKSLWVERTSLYLVQSLPG
ISRWFEVEKREVVEMSPLENAIEVLENKNQQLKTLISQCQTRQMQNINPLTMCLNGVIDA
AVNGGVSRYQEAFFVKEYILSHPEDGEKIARLRELMLEQ---AQILEFGLAVHEKFVPQD
MRPLHKKLVDQFFVMKSSLGIQEFSACMQASPVHFPNGSPRVCRNSAPASVSPDGTRVIP
RR---SPLSYPAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQ--------------
--------PSPSTSSLSSTHSASPNVTSSAPSSARASPLLSDKHKHSRENSCLSPRERPC
SAIYPTPVEPS-------------------------------------------------
-------QRMLFNHIGDG-ALPRSDPNLSAPEKAVNPTPSSWSLDSGKEAKNMSDSGKLI
SPPVPPRPTQTASPARHTTSV-SPSPAGRSPLK----------------GSVQSFTPSPV
EYH--SPGLISNSPVLSGSYSSGISSLSRCSTSETSGFENQVNEQSAPLPVPV-------
----PVPVPS-YGGEEPVRKESKTPPPYSVYERTLRRPVPLPHSLSIPV------TSEPP
ALPPKPLAARSSHLENG-ARRTDPGPRPRPLPRKVSQL-

------------------TWNTFEYSAFLTVIASFRGTVPYGLSLEIGDTVQILEKCDGW
YRGFAFKNPNIKGIFPSS--YVHLKNACVKNKGQFEMVIPTEDSVITEMTSTLRDWGAMW
KQLYVRNEGDLFHRLWHIMNEILDLRRQVLVGHLTHDRMKDVKRHITARLDWGNEQLGLD
LVPRKEYAMVDPEDISITELYRL---------------------------------MEHR
HRKKDTPVQASSHHLFVQMKSLMCSNLGEELEVIFSLFDSKENRPISERFFLRLNRNGLP
KAPDKPERHCSLFVDLGSSELRKDIYITVHIIRI---GRYSSCQYGGASKNEYMSTFVNF
CGKRTQSLSLTAESKNNSTLLLGMCNTESEWYQIHENIIKKLNARYNLTGSNAGLAVSLQ
LLHGDIE-QIRREYSSVFSHGVSITRKLGFSNIIMPGEMRNDLYITIERGEFEKGGKSVA
RNVEVTMFIIDCGGHILKDFISFGSGE------PSASEYHSFVLYH--NNSPRWSELLKL
PIPVDKFRGAHIRFEFRHCSTKEK---GEKKLFGFSFVPLMQEDGRTLPDGTHELIVHKC
EENTNLQDTTRYLKLPFSKGI-FLGNNNQAMKATKESFWITSFLCSTKLTQN---GDMLD
LLKWRTHP----------DKITGCLSKLKEIDGSEIVKFLQDTLDTLFGILDENSQKYGS
KVFDSLVHIINLLQDSKFHHFKPVMDTYIESHFAGA--LAYRDLIKVLKWYVDRITEAER
QEHIQEVLKAQEYIFKYIVQSRRLFSLATGGQNEEEFRCCIQELLMSVRFFLSQESKGSG
ALSQSQAVFLSSFPAVYSELLKLFDVREVANLVQDTLGCLPTIVNVDDALQAIKLQCIGK
TVE-SQLYTNPDSRYILLPVVLHHLHMHLQEQKDLIMCARILSNVFCLIKKNSSEKSVLE
EIDVIVASLLDILLRTILEITSRPQPSSSAMRLQFQDVTKCIGFYNVRESVHGSTVN---
----TFPVFPYTPLLYPLSHRVDGEFVACLLSLLRQMTDRHYQQLLDSFNTKEELRDFLL
QIFTV-----FRILIRPE------MFPKDWTVMRLVA----NNVIITTVLYLSDALRKNF
LNENFDYKIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKYG-----DMRVTMGCEIF
SMWQNLGEHKLHFIPALIGPFLEVTLIPQPDLRNVMIPIFHDMM------DWEQRRSGNF
KQVEAKLIDKLDSLMSEGKGDETYRELFNSIIPLFGP---YPSLLKKIERETWRESGVSL
IATVTRLMERLLDYRDCMKMGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHL
KAQNFTEAAYTLLLYDELLEWSDRPLREFLAYPMQTEWQRKEHLHLTIIQNFDRGKCWEN
GIILCRKIAEQYESYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLR
NKEFVCRGHDYERLEAFQQRMLNEFPHAVAMQHANQPDETIFQAEAQYLQIYAVTPIPES
QEVLQREGVPDNIK

PF06920 // ENSGT00610000085806_3_Domain_5 (1575, 1759)

SFYKVNHIWKFRYDRPFHKGTKDKENEFKSLWVERTSLYLVQSLPG
ISRWFEVEKREVVEMSPLENAIEVLENKNQQLKTLISQCQTRQMQNINPLTMCLNGVIDA
AVNGGVSRYQEAYFTLHDVLSWPDKGFKPLSVKPYVLIK---AQILEFGLAVHEKFVPQD
MRPLHKKLVDQFFVMKSSLGIQEFSACIQASPVHFPNGSPRVCRNSAPASVSPDGTRVIP
RRR-NSPLSYPAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQ--------------
--------PSPSTSSLSSTHSASPNVTSSAPSSARASPLLSDKHKHSRENSCLSPRERPC
SAIYPTPVEPS-------------------------------------------------
-------QRMLFNHIGDG-ALPRSDPNLSAPEKAVNPTPSSWSLDSGKEAKNLSDSGKLI
SPPVPPRPTQTASPARHTTSV-SPSSAGRSPMKQ---------------GSVQSFTPSPV
EYH--SPGLISNSPVLSGSYSSGISSLSRCSTSETSGFENQVNEQTAP------------
----VPVPSY-PGPEEPVRKESKTPPPYSVYERTLRRPVPLPHSLSIPI------AAEPP
ALPPKPLAARSSHLENG-TRRTDPGPRPRPLPRKVSQL-

--------------EF---NPQFHQKKKKKFIASFRGTVPYGLSLEIGDTVQILEKCDGW
YRGFALKNPNIKGIFPSS--YVHLKNACV

PF16172 // ENSGT00610000085806_3_Domain_1 (90, 451)

KNKGQFEMVIPTEDSVITEMTSTLRDWGTMW
KQLYVRNEGDLFHRLWHIMNEILDLRRQVLVGHLTHDRMKDVKRHITARLDWGNEQLGLD
LVPRKEYAMVDPEDISITELYRL---------------------------------MEHR
HRKKDTPVQASSHHLFVQMKSLMCSNLGEELEVIFSLFDSKENRPISERFFLRLNRNGLP
KAPEKPERHCSLFMDLGSSELRKDIYITVHIIRI---GRMGAGEKKNACSVQYRRPFG--
CAVLSIADLLTGETKDDLVLKVYMCNTESEWYQIHENIIKKLNARYNLTGSNAGLAVSLQ
LLHGDIE-QIRREYSSVFSHGVSITRKLGF

ENSGT00610000085806_3_Linker_1_3 (451, 456)

SNIIM

PF14429 // ENSGT00610000085806_3_Domain_3 (456, 652)

PGEMRNDLYITIERGEFEKGGKSVA
RNVEVTMFIVDSSGQTLKDFISFGSGE------PPASEYHSFVLYH--NNSPRWSELLKL
PIPVDKFRGAHIRFEFRHCSTKEK---GEKKLFGFSFVPLMQEDGRTLPDGTHELIVHKC
EENTNLQDTTRYLKLPFSKGI-FLGNNNQAMKATKESFWITSFLCSTKLTQ

ENSGT00610000085806_3_Linker_3_5 (652, 1250)

N---GDMLD
LLKWRTHP----------DKITGCLSKLKEIDGSEIVKFLQDTLDTLFGILDENSQKYGS
KVFDSLVHIINLLQDSKFHHFKPVMDTYIESHFAGA--LAYRDLIKVLKWYVDRITEAER
QEHIQEVLKAQEYIFKYIVQSRRLFSLATGGQNEEEFRCCIQELLMSVRFFLSQESKGSG
ALSQSQAVFLSSFPAVYSELLKLFDVREVANLVQDTLGSLPTFMHVDESLQAIKLQCIGK
TVE-SQLYTNPDSRYILLPVVLHHLHIHLQEQKDLIMCARILSNVFCLIKKNSSEKSVLE
EIDVIVASLLDILLRTILEITSRPQPSSSAMRLQFQDV----------------------
----------------------TGEFVACLLSLLRQMTDRHYQQLLDSFNTKEELKDFLL
QIFTV-----FRILIRP-----EMF-PKDWTVMRLVA---NN-VIITTVLYLSDALRKNF
LNENFDYKIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKYG-----DMRVTMGCEIF
SMWQNLGEHKFHFIPSLIGPFLEVTLIPQPDLRNVMIPIFHDMM-----

PF06920 // ENSGT00610000085806_3_Domain_5 (1250, 1759)

-DWEQRRSGSF
KQVEAKLIDKLDSLMSEGKGDETYRELFNSIIPLFGP---YPSLLKKIERETWRESGVSL
IATVTRLMERLLDYRDCMKMGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHL
KAQNFTEAAYTLLLYDELLEWSDRPLREFLTYPMQTEWQRKEHLHLTIIQNFDRGKCWEN
GIILCRKIAEQYESYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLR
NKEFVCRGHDYERLEAFQQRMLTEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPIPES
QEVLQREGVPDNIKSFYKVNHIWKFRYDRPFHKGTKDKENEFKSLWVERTSLCLVQSLPG
ISRWFEVEKREVVEMSPLENAIEVLENKNQQLKTLISQCQTRQMQNINPLTMCLNGVIDA
AVNGGVSRYQEAFFVKEYILSHPEDGEKIARLRELMLEQ---AQILEFSLAVHEKFVPQD
MRPLHKKLVDQFFVMKSSLGIQEFSACIQASPVHFPNGSPRVCRNSAPASMSPDGTRVIP
RR---SPLSYPAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQ--------------
--------PSPSTSSLSSTHSASPNVTSSAPSSARASPLLSDKHKHSRENSCLSPRERPC
SAIYPTPGEPS-------------------------------------------------
-------QRMLFNHIGDG-ALPRSDPNLSAPDKAVNPTPSSWSLDSGKEAKNMSDSGKLI
SPPVPPRPTQTASPARHTTAV-SPSPAGRSPLK----------------GSAQSFTPSPV
DYH--PPGLTSNSPVLSGSYSSGISSLSRCSVSETSGFESQAAEPPTVP-----------
--------GC-SGPEEPTRRESKTPPPYSVFERSLRRPAPLPHSLSIPA-----------
--------------ANG-PRRTEPGPRPRPLPRKVSQL-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------MKIGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHL
KAQNFTEAAYTLLLYDELLEWSDRPLREFLTYPMQTEWQRKEYLHLTVIQNFDRGKCWEN
GIILCRKIAEQYESYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLR
NKEFVCRGHDYERLEAFQQRMLTEFPHAITMQHVNQPDETIFQAEAQYLQIYAVTPIPES
QEVLQREGIPDNIK

PF06920 // ENSGT00610000085806_3_Domain_5 (1575, 1633)

SFYKVNHIWRFRYDRPFHKGTKDKENEFKSLWVERTSLILVQSLPG
ISRWFEVEKREVVSEA--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------

--------------MWIP----TEHEK

PF07653 // ENSGT00610000085806_3_Domain_0 (28, 82)

YGVVIASFRGTVPYGLSLEIGDTVQILEKCDGW
YRGFALKNPNIKGIFPSS--Y

ENSGT00610000085806_3_Linker_0_1 (82, 90)

VHLKNACV

PF16172 // ENSGT00610000085806_3_Domain_1 (90, 451)

KNKGQFEMVIPTEDSVITEMTSTLRDWGTMW
KQLYVRNEGDLFHRLWHIMNEILDLRRQVLVGHLTHDRMKDVKRHITARLDWGNEQLGLD
LVPRKEYAMVDPEDISITELYRL---------------------------------MEHR
HRKKDTPVQASSHHLFVQMKSLMCSNLGEELEVIFSLFDSKENRPISERFFLRLNRNGLP
KAPDKPERHCSLFVDLGSSELRKDIYITVHIIRI---GRMGAGEKKNACSVQYRRPFG--
CAVLSIADLLTGETKDDLVLKVYMCNTESEWYQIHENIIKKLNARYNLTGSNAGLAVSLQ
LLHGDIE-QIRREYSSVFSHGVSITRKLGF

ENSGT00610000085806_3_Linker_1_3 (451, 456)

SDIIM

PF14429 // ENSGT00610000085806_3_Domain_3 (456, 652)

PGEMRNDLYITVERGEFEKGGKSVA
RNVEVTMFIVDSNGQPLKDFISFGSGE------PPASEYHSFVLYH--NNSPRWSELLKL
PIPVDKFRGSHIRFEFRHCSTKEK---GEKKLFGFSFVPLMQEDGRTLPDGTHELIVHKC
EENTNLQDTTRYLKLPFSKVI-FLGNNNQTMKATKESFWITSFLCSTKLTQ

ENSGT00610000085806_3_Linker_3_5 (652, 1250)

N---GDMLD
LLKWRTHP----------DKITGCLSKLKEIDGSEIVKFLQDTLDTLFGILDENSQKYGS
KVFDSLVHIINLLQDSKFHHFKPVMDTYIESHFAGA--LAYRDLIKVLKWYVDRITEAER
QEHIQEVLKAQEYIFKYIVQSRRLFSLATGGQNEEEFRCCIQELLMSVRFFLSQESKGTG
ALSQSQAVFLSSFPAVYSELLKLFDVREVANLVQDTLGSLPTIMHVDDSLQAIKLQCIGK
TVE-SQLYTNPDSRYILLPVVLHHLHIHLQEQKDLIMCARILSNVFCLIKKNSSEKSVLE
EIDVIVASLLDILLRTILEITSRPQASSSAMRLQFQDV----------------------
----------------------TGEFVACLLSLLRQMTDRHYQQLLNSFNTKEELRDFLL
QIFTV-----FRILIRP-----EMF-PKDWTVMRLVA---NN-VIITTVLYLSDALRKNF
LNENFDYKIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKYG-----DMRVTMGCEIF
SMWQNLGEHKLHFIPALIGPFLEVTLIPQPDLRNVMIPIFHDMM-----

PF06920 // ENSGT00610000085806_3_Domain_5 (1250, 1757)

-DWEQRKSGNF
KQVEAKLIDKLDSLMSEGKGDETYRELFNSIIPLFGP---YPSLLKKIERETWRESGVSL
IATVTRLMERLLDYRDCMKIGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHL
KAQNFTEAAYTLLLYDELLEWSDRPLREFLTYPMQTEWQRKEHLHLTIIQNFDRGKCWEN
GIILCRKIAEQYESYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLR
NKEFVCRGHDYERLEAFQQRMLNEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPIPES
QEVLQREGVPDNIKSFYKVNHIWKFRYDRPFHKGTKDKENEFKSLWVERTSLYLVQSLPG
ISRWFEVEKREVVEMSPLENAIEVLENKNQQLKTLISQCQTRQMQNINPLTMCLNGVIDA
AVNGGVSRYQEAFFVKDYILSHPEDGEKIARLRELMLEQ---AQILEFGLAVHEKFVPQD
MRPLHKKLVDQFFVMKSSFGIQEFPACIQASPVHFPNGSPRVCRNSAPASMSPDGARVIP
RR---SPLSYPAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQ--------------
--------PSPSTSSLSSTHSASPNVTSSAPSSARASPLLSDKHKHSRENSCLSPRDRPC
SAIYPTPVEPS-------------------------------------------------
-------QRMLFNHIGDG-ALPRSDPNLSAPEKAVNPTPSSWSLDSGKEAKTVSDSGKLI
SPPVPPRPTQTASPARHTTSV-SPSPAGRSPLK----------------GSVQSFTPSPV
EYN--SPGLSSNSPVLSGSYSSGISSLSRCSTSETSGFENQANEQSVPV----PVPV--P
--VPVPVPSF-SGSEEPVRKESKTPPPYSVYERTLRRPVPLPHSLSIPV------TSEPP
ALPPKPLAARSSHLENG-TRRTEPGPRPRPLPRKVSQL-

--------------------------RWIGFIASFRGTVPYGLSLEIGDTVQILEKCDGW
YRGFALKNPNIKGIFPSS--YVHLKNACV

PF16172 // ENSGT00610000085806_3_Domain_1 (90, 451)

KNKGQFEMIIPTEDSVITEMTSTLRDWGTMW
KQLYVRNEGDLFHRLWHIMNEILDLRRQVLVGHLTHDRMKDVKRHITARLDWGNEQLGLD
LVPRKEYAMVDPEDISITELYRL---------------------------------MEHR
HRKKDTPVQASSHHLFVQMKSLMCSNLGEELEVIFSLFDSKENRPISERFFLRLNRNGLP
KAPDKPERHCSLFVDLGSSELRKDIYITVHIIRI---GRMGAGEKKNACSVQYRRPFG--
CAVLSIADLLTGETKDDLILKVYMCNTESEWYQIHENIIKKLNARYNLTGSNAGLAVSLQ
LLHGDIE-QIRREYSSVFSHGVSITRKLGF

ENSGT00610000085806_3_Linker_1_3 (451, 456)

SNIIM

PF14429 // ENSGT00610000085806_3_Domain_3 (456, 652)

PGEMRNDLYITIERGEFEKGGKSVA
RNVEVTMFIVDSSGQTLKDFISFGSGE------PPASEYHSFVLYH--NNSPRWSELLKL
PIPVDKFRGAHIRFEFRHCSTKEK---GEKKLFGFSFVPLMQEDGRTLPDGTHELIVHKC
EENTNLQDTTRYLKLPFSKGI-FLGNNNQAMKATKESFCITSFLCSTKLTQ

ENSGT00610000085806_3_Linker_3_5 (652, 1250)

N---GDMLD
LLKWRTHP----------DKITGCLSKLKEIDGSEIVKFLQDTLDTLFGILDENSQKYGS
KVFDSLVHIINLLQDSKFHHFKPVMDTYIESHFAGA--LAYRDLIKVLKWYVDRITEAER
QEHIQEVLKAQEYIFKYIVQSRRLFSLATGGQNEEEFRCCIQELLMSVRFFLSQESKGSG
ALSQSQAVFLSSFPAVYSELLKLFDVREVANLVQDTLGSLPTILHVDDSLQAIKLQCIGK
TVE-SQLYTNPDSRYILLPVVLHHLHIHLQEQKDLIMCARILSNVFCLIKKNSSEKSVLE
EIDVIVTSLLDILLRTILEITSRPQPSSSAMRFQFQDVTRTGFLNRESLKW---------
-----------------------QSYTEQLFSLCR----HTYE-----VPLSSRHTDFLL
QIFTV-----FRILIRP-----EMF-PKDWTVMRLVA---NN-VIITTVLYLSDALRKNF
LNENFDYKIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKYG-----DMRVTMGCEIF
SMWQNLGEHKLHFIPALIGPFLEVTLIPQPDLRNVMIPIFHDMM-----

PF06920 // ENSGT00610000085806_3_Domain_5 (1250, 1759)

-DWEQRRSGNF
KQVEAKLIDKLDSLMSEGKGDETYRELFNSIIPLFGP---YPSLLKKIERETWRESGVSL
IATVTRLMERLLDYRDCMKMGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHL
KAQNFTEAAYTLLLYDELLEWSDRPLREFLTYPMQTEWQRKEHLHLTIIQNFDRGKCWEN
GIILCRKIAEQYESYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLR
NKEFVCRGHDYERLEAFQQRMLNEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPIPES
QEVLQREGVPDNIKSFYKVNHIWKFRYDRPFHKGTKDKENEFKSLWVERTSLYLVQSLPG
ISRWFEVEKREVVEMSPLENAIEVLENKNQQLKTLISQCQTRQMQNINPLTMCLNGVIDA
AVNGGVSRYQEAFFVKEYILSHPEDGEKIARLRELMLEQ---AQILEFGLAVHEKFVPQD
MRPLHKKLVDQFFVMKSSLGIQEFSACMQASPIHFPNGSPRVCRNSAPASVSPDGTRVIP
RR---SPLSYPAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQ--------------
--------PSPSTSSLSSTHSASPNVTSSAPSSARASPLLSDKHKHSRENSCLSPRERPC
SAIYPTPVEPS-------------------------------------------------
-------QRMLFNHIGDG-ALPRSDPNLSAPEKAVNPTPSSWSLDSGKEAKNMSDSGKLI
SPPVPPRPTQTASPARHTTS-ISPSPAGRSPLK----------------GSVQSFTPSPV
EYH--SPGLISNSPVLSGSYSSGISSLSRCSTSETSGFENQVNEQSAPVPVPVPMP----
--LPVPV--PTYGGEEPVRKESKTPPPYSVYERTLRRPVPLPHSLSIPV------TPEPP
ALPPKPLAARSSHLENG-ARRTDPGPRPRPLPRKVSQL-

--------------------------SWVGFIASFRGTVPYGLSLEIGDTVQILEKCDGW
YRGFALKNPNIKGIFPSS--YVHLKNACV

PF16172 // ENSGT00610000085806_3_Domain_1 (90, 451)

KNKGQFEMVIPTEDSVITEMTSTLRDWGTMW
KQLYVRNEGDLFHRLWHIMNEILDLRRQVLVGHLTHDRMKDVKRHITARLDWGNEQLGLD
LVPRKEYAMVDPEDISITELYRL---------------------------------MEHR
HRKKDTPVQASSHHLFVQMKSLMCSNLGEELEVIFSLFDSKENRPISERFFLRLNRNGLP
KAPDKPERQCSLFVDLGSSELRKDIYITVHIIRI---GRMGAGEKKNACSVQYRRPFG--
CAVLSIADLLTGETKDDLILKVYMCNTESEWYQIHENIIKKLNARYNLTGSNAGLAVSLQ
LLHGDIE-QIRREYSSVFSHGVSITRKLGF

ENSGT00610000085806_3_Linker_1_3 (451, 456)

SNIIM

PF14429 // ENSGT00610000085806_3_Domain_3 (456, 652)

PGEMRNDLYITIERGEFEKGGKSVA
RNVEVTMFIVDSSGQTLKDFISFGSGE------PPASEYHSFVLYH--NNSPRWSELLKL
PIPVDKFRGAHIRFEFRHCSTKEK---GEKKLFGFSFVPLMQEDGRTLPDGTHELIVHKC
EENTNLQDTTRYLKLPFSKGI-FLGNNNQAMKATKESFCITSFLCSTKLTQ

ENSGT00610000085806_3_Linker_3_5 (652, 1250)

N---GDMLD
LLKWRTHP----------DKITGCLSKLKEIDGSEIVKFLQDTLDTLFGILDENSQKYGS
KVFDSLVHIINLLQDSKFHHFKPVMDTYIESHFAGA--LAYRDLIKVLKWYVDRITEAER
QEHIQEVLKAQEYIFKYIVQSRRLFSLATGGQNEEEFRCCIQELLMSVRFFLSQESKGSG
ALSQSQAVFLSSFPAVYSELLKLFDVREVANLVQDTLGSLPTILHVDDSLQAIKLQCIGK
TVE-SQLYTNPDSRYILLPVVLHHLHIHLQEQKDLIMCARILSNVFCLIKKNSSEKSVLE
EIDVIVASLLDILLRTILEITSRPQPSSSAMRFQFQDVTRTGFLNRESLHDSSTLSTFSF
CADTYGKVPMTGRH--------TGEFVACLLSLLRQMTDRHYQQLLDSFNTKEELRDFLL
QIFTV-----FRILIRP-----EMF-PKDWTVMRLVA---NN-VIITTVLYLSDALRKNF
LNENFDYKIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKYG-----DMRVTMGCEIF
SMWQNLGEHKLHFIPALIGPFLEVTLIPQPDLRNVMIPIFHDMM-----

PF06920 // ENSGT00610000085806_3_Domain_5 (1250, 1759)

-DWEQRRSGNF
KQVEAKLIDKLDSLMSEGKGDETYRELFNSIIPLFGP---YPSLLKKIERETWRESGVSL
IATVTRLMERLLDYRDCMKMGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHL
KAQNFTEAAYTLLLYDELLEWSDRPLREFLTYPMQTEWQRKEHLHLTIIQNFDRGKCWEN
GIILCRKIAEQYESYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLR
NKEFVCRGHDYERLEAFQQRMLNEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPIPES
QEVLQREGVPDNIKSFYKVNHIWKFRYDRPFHKGTKDKENEFKSLWVERTSLYLVQSLPG
ISRWFEVEKREVVEMSPLENAIEVLENKNQQLKTLISQCQTRQMQNINPLTMCLNGVIDA
AVNGGVSRYQEAFFVKEYILSHPEDGEKIARLRELMLEQ---AQILEFGLAVHEKFVPQD
MRPLHKKLVDQFFVMKSSLGIQEFSACMQASPVHFPNGSPRVCRNSAPASVSPDGTRVIP
RR---SPLSYPAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQ--------------
--------PSPSTSSLSSTHSASPNVTSSAPSSARASPLLSDKHKHSRENSCLSPRERPC
SAIYPTPVEPS-------------------------------------------------
-------QRMLFNHIGDG-ALPRSDPNLSAPEKAVNPTPSSWSLDSGKEAKNMSDSGKLI
SPPVPPRPTQTASPARHTTSV-SPSPAGRSPLK----------------GSVQSFTPSPV
EYH--SPGLISNSPVLSGSYSSGISSLSRCSTSETSGFENQVNEQSVPLPVPV-------
----PVPVPV-YGGEEPVRKESKTPPPYSVYERTLRRPVPLPHSLSIPV------TPEPP
ALPPKPLAARSSHLENG-ARRTDPGPRPRPLPRKVSQL-

------------------MWIPTEHEK

PF07653 // ENSGT00610000085806_3_Domain_0 (28, 81)

YGVVIASFRATVPYGLSLEIGDTVQILEKCDGW
YRGFALKNPNIKGIFPSS--YIHLKNACVKNKGQFEMVIPTEDSVITEMTSTLRDWGTMW
KQLYVRNEGDLFHRLWHIMNEILDLRRQVLVGHLTHDRMKDVKRHITARLDWGNEQLGLD
LVPRKEYAMVDPEDISITELYRL---------------------------------MEHR
HRKKDTPVQASSHHLFVQMKSLMCSNLGEELEVIFSLFDSKENRPISERFFLRLNRNGLP
KSPEKPERHCSLFVDLGSSELRKDIYITVHIIRI---GRMGAGEKKNACSVQYRRPFG--
CAVLSIADLLTGETKDDLILKVYMCNTESEWYQIHENIIKKLNARYNLTGSNAGLAVSLQ
LLHGDIE-QIRREYSSVFTHGVSITRKLGFSNIIMPGEMRNDLYITIERGEFEKGGKSVA
RNVEVTMYIIDSNGQNLKDFISFGSGE------PPANEFHSFVLYH--NNSPRWSELLKL
PIPVDKFRGSHIRFEFRHCSTKEK---GEKKLFGFSFVPLMQEDGRTLPDGTHELIVHKC
EENTNLQDSSRYLRLPFSKVS-LLGTNNQAIKATKESFWITSFLCSTKLTQN---GDMLD
LLKWRTHP----------DKITGCLSKIKEIDGSEIVKFLQDTLDTLFGILDENSQKYGS
KVFDSLVHIINLLQDSKFHHFKPVMDTYIESHFAGA--LAYRDLIKVLKWYVDRITEAER
QEHIQEVLKAQEYIFKYIVQSRRLFSLATGGQNEEEFRCCIQELLMSVRFFLSQESKGSG
ALSQSQAVFLSSFPAVYSELLKLFDVREVANLVHDTLGSLPTIMHVDDSLQAVKLQCIGK
TVE-SQLYTNPDSRYILLPVVLHHLHMHLQEQKDLIMCARILSNIFCLIKKNSSEKSVLE
EIDVIVTSLLDILLRTILEITSRPQPSGSAMRLQFQDV----------------------
----------------------TGEFVACLLSLLRQMTDRHYQQLLDGFSTKEELRDFLL
QIFTV-----FRILIRP-----EMF-PKDWTVMRLVA---NN-VIITTVLYLSDALRKNF
LNENFDYKIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKYG-----DMRVTMGCEIF
SMWQNLGEHKLHFIPALIGPFLEVTLIPQPDLRNVMIPIFHDMM------DWEQRRSGNF
KQVEAKLIDKLDSLMSEGKGDETYRELFNSIIPLFGP---YPSLLKKIERETWRESGVSL
IATVTRLMERLLDYRDCMKMGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHL
KAQNFTEAAYTLLLYDELLEWSDRPLREFLTYPMQTEWQRKEYLHLTIIQNFDRGKCWEN
GIILCRKIAEQYESYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLR
NKEFVCRGHDYERLEAFQQRMLNEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPIPES
QEVLQREGIPDNIK

PF06920 // ENSGT00610000085806_3_Domain_5 (1575, 1759)

SFYKVNHIWRFRYDRPFHKGTKDKENEFKSLWVERTSLILVQSLPG
ISRWFEVEKREVVEMSPLENAIEVLENKNQQLKTLISQCQTRQMQNINPLTMCLNGVIDA
AVNGGVSRYQEAFFVKEYILNHPEDGEKITRLRELMLEQ---AQILEFGLAVHEKFVPQD
MRPLHKKLVDQFFVMKSSLGIQEFSACIQASPVHFPNGSPRVCRNSAPASMSPDGARVIP
RR---SPLSYPAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQ--------------
--------PSPSTSSLSSTHSASPNVTSSAPSSARASPLLSDKHKHSRENSCLSPRERPC
SAIYPTPTEPS-------------------------------------------------
-------QRMLFNHIGDG-PLPRSDPNLSAPDKAVNPTPSSWSLDSGKEAKNMLDSGKLI
SPPVPPRPTQTASPARHGTSV-SPSPAGRSPMK----------------GSMQSFTPSPV
EYH--SSGLISNSPVLSGSYSSGISSLSRCSTSETSGFENPVNEQTV---------SMS-
--------TY-SVPEEPVRKESKTPPPYSVYERTLRRPAPLPHSLSIPV------TSEPP
ALPPKPLLARSTNLENG-SRRTEQVPRPRPLPRKVSQL-

------------------------------

PF00018 // ENSGT00610000085806_3_Domain_0 (31, 85)

VIASFRGTIPYGLSLEIGDTVQILEKCDGW
YRGFALKNPNIKGIFPSS--YVHLKNACVKNKGQFEMVIPTEDSVITEMTSTLRDWGTMW
KQLYVXXXXXXXXXXXXXXXXXXXXXXXXXXXXX---------XXXX------XXXXXX-
-------------XXXXX----XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMEHR
HRKKDTPVQASSHHLFVQMKSLMCSNLGEELEVIFSLFDSKENRPISERFFLRLNRNGLP
KAPDKPERHCSLFVDLGSSELRKDIFITVHIIRI---GRMGAGEKKNACSVQYRRPFG--
CAVLSIADLLTGETKDDLILKVYMCNTESEWYQIHENIIKKLNARYNLTGSNAGLAVSLQ
LLHGDIE-QIRKEYSSVFSHGVSITRKLGFSNIIMPGEMRNDLYITIERGEFEKGGKSVA
RNVEVTMFIIXXXXXXXXDFISFGSGE------PPASEYHSFVLYH--NNSPRWAELLKL
PIPVDKFRGAHIRFEFRHCSTKEK---GEKKLFGFSFVPLMQEDGRTLPDGTHELIVHKC
EENTNLQDTTRYLKLPFSKGI-FLGNNNQAMKATKESFWITSFLCSTKLTQN---GDMLD
LLKWRTHP----------DKITGCLSKLKEIDGSEIVKFLQDTLDTLFGILDENSQKYGS
KVFDSLVHIINLLQDSKFHHFKPVMDTYIESHFAGA--LAYRDLIKVLKWYVDRITEAER
QEHIQEVLKAQEYIFKYIVQSRRLFSLATGGQNEEEFRCCIQELLMSVRFFLSQESKGSG
ALSQSQAVFLSSFPAVYSELLKLFDVREVANLVQDTLGSLPTIMHVDDSLQAIKLQCIGK
TVE-SQLYTNPDSRYILLPVVLHHLHIHLQEQKDLIMCARILSNVFCLIKKNSSEKSVLE
EIDVIVASLLDILLRTILEITSRPQSSGSSMRFQFQDVTGFV------------------
----------------------------ALLSLLRQMTDRHYQQLLDSFSTKEELRXXXX
XXXXX-----XXXXXXXX------XXXXXXXXXXXXXX----XVIITTSLFLSDALRKNF
LNENFDYKIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKYG-----DMRVTMGCEIF
SMWQNLGEHKLHFIPALIGPFLEVTLIPQPDLRNVMIPIFHDMM------DWEQRRSGNF
KQVEAKLIDKLDSLMSEGKGDETYRELFNSXXXXXXX---XXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXDCMKMGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHL
KAQNFTEAAYTLLLYDELLEWSDRPLREFLTYPMQTEWQRKEHLHLTIIQNFDRGKCWEN
GIILCRKIAEQYENYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLR
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXLQIYAVTPIPES
QEVLQREGVPDNIKSFYKVNHIWKFRYDRPFHKGTKDKENEFKSLWVERTSLYLVQSLPG
ISRWFEVEKREVVEMSPLENATEVLENNQQL---TLISCQTRQMQISL------MLMGDD
AAVNGVSRYQXAFFVKEYILSHPEDGEKIARLRELMLEQ---AQILEFGLAVHEKFVPQD
MRPLHKKLVDQFFVMKSSLGIQEFAACTQASPVHFPNGSPRVCRNSAPASMSPDGTRVIP
RR---SPLSYPAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQ--------------
--------PSPSTSSLSSTHSASPNVTSSAPSSARASPLLSDKHKHSRENSCLSPRERPC
SAIYPTPVEPS-------------------------------------------------
-------QRMLFNHIGDG-ALPRSDASLSAPEKAVNPTPSSWSLDSGKEAKNVSDSGKLI
SPPVPPRPTQTASPARHTTTSVSPSPAGRSPLK---------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------

------------------------------

PF07653 // ENSGT00610000085806_3_Domain_0 (31, 84)

VIASFRGTVPYGLSLEIGDTVQILEKCDGW
YRGFALKNPNIKGIFPSS--YVHLKNAYVKNKGQFEMVIPTEDSVITEMTSTLRDWGTMW
KQLYVRNEGDLFHRLWHIMNEILDLRRQVLVGHLTHDRMKDVKRHITARLDWGNEQLGLD
LVPRKEYAMVDPEDISITELYRL---------------------------------MEHR
HRKKDTPVQASSHHLFVQMKSLMCSNLGEELEVIFSLFDSKENRPISERFFLRLNRNGLP
KAPDKPERHCSLFVDLGSSELRRDIYITVHIIRI---GRMGAGEKKNACSVQYRRPFG--
CAVLSIADLLTGETKDDLILKVYMCNTESEWYQIHENIIKKLNARYNLTGSNAGLAVSLQ
LLHGDIE-QIRREYSSVFSHGVSITRKLGFSNIIMPGEMRNDLYITIERGEFEKGGKSVA
RNVEVTMFIVESSGQTLKDFISFGSGE------PPASEYHSFVLYH--NNSPRWSELLKL
PIPVDKFRGAHIRFEFRHCSXXXX---XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXC
EENTNLQDTTRYLKLPFSKGI-LLGTNNQAMKATKESFWITSFLCSTKLTQN---GDMLD
LLKWRTHP----------DKITGCLSKLKEIDGSEIVKFLQDTLDTLFGILDENSQKYGS
KVFDSLVHIINLLQDSKFHHFKPVMDTYIESHFAGA--LAYRDLIKVLKWYVDRITEAER
QEHIQEVLKAQEYIFKYIVQSRRLFSLATGGQNEEEFRCCIQELLMSVRFFLSQESKGSG
ALSQSQAVFMSSFPAVYSELVKLFDVREVANLVQDTLGSLPTIIHVDDALQAVKLQCIGK
TVE-SQLYTNPDSRYILLPVVLHHLHMHLQEQKHLIMCARILSNVFCLIKKNSSEKSVLE
EIDVIVASLLDILLRTILEITSPPQPSGSTMRLQFQDVTTGFLNREALCGSAPT------
-------LSLSVFIEKVLPISESGEFVACLLSLLRQMTDRHYQQLLDSFNTKEELRDFLL
QVFTV-----FRILIRP-----EMF-PKDWTVMRLVA---NN-VIITTVLYLSDALRKNF
LNENFDYKXXXXXXXXXXXXXXXXXXXXXXXXXXKKKKVLEKYG-----DMRVTMGCEIF
SMWQNLGEHKLHFIPALIGPFLEVTLIPQPDLRNVMIPIFHDMM------DWEQRRSGNF
KQ-EAELFDNLDSLMSD-QSDETYRELFNSXXXXXXX---XXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXNFYKTELNKEEMYIRYIHKLYDLHL
KAQNFTEAAYTLLLYDELLEWSDRPLREFLTYPMQTEWQRKEHLHLTIIQNFDRGKCWEN
GIILCQKIAEQYESYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLR
NKEFVCRGHDYERLEAFQQRMLNEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPPEXX
XXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXSLWVERTSLYLVQSLPG
ISRWFEVEKREVVEMSPLENAIEVLENKNQQLKTLISQCQTRQMQNINPLTMCLNGVIDA
AVNGGVSRYQEAFFVKEYILSHPEDGEKIARLRELMLEQ---AQILEFGLAVHEKFVPQD
MRPLHKKLVDQFFVMKSSLGIQEFSACIQASPVHFPNGSPRVCRNSAPASMSPDGTRVIP
RR---SPLSYPAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQ--------------
--------PSPSTSSLSSTHSASPNVTSSAPSSARASPLLSXXXXXXXXXXXXXXXXXX-
-------------------------------------------------------XXXXX
XXXXXXXXRLLFNHIGDG-ALPRSDPNLSAPEKAVNPTPSSWSLDSGKEAKNMSDSGKLI
SPPVPPRPTQTASPARHTTSV-SPSPAGRSPLK----------------GSVPPFTPS-V
EYH--SPGLIS-SPVLSGS-----------------------------------------
------------------------------------------------------------
---------------------------------------

------------------------------VIASFRGTVPYGLSLEIGDTVQILEKCDGW
YRGFALKNPNIKGIFPSS--YVHLKNACV

PF16172 // ENSGT00610000085806_3_Domain_1 (90, 451)

KNKGQFEMVIPTEDSVITEMTSTLRDWGTMW
KQLYVRNEGDLFHRLWHIMNEILDLRRQVLVGHLTHDRMKDVKRHITARLDWGNEQLGLD
LVPRKEYAMVDPEDISITELYRL---------------------------------MEHR
HRKKDTPVQASSHHLFVQMKSLMCSNLGEELEVIFSLFDSKENRPISERFFLRLNRNGLP
KAPDKPDRHCSLFVDLGSSDLRKDIYITVHIIRI---GRMGAGEKKNACSVQYRRPFG--
CAVLSIADLLTGETKDDLVLKVYMCNTESEWYQIHENIIKKLNARYNLTGSNAGLAVSLQ
LLHGDIE-QIRREYSSVFSHGVSITRKLGF

ENSGT00610000085806_3_Linker_1_3 (451, 456)

SNIIM

PF14429 // ENSGT00610000085806_3_Domain_3 (456, 652)

PGEMRNDLYITIERGEFEKGGKSVA
RNVEVTMFIVDSNGQPLKDFISFGSGE------PPATEYHSFVLYH--NNSPRWSELLKL
PIPVDKFRGSHIRFEFRHCSTKEK---GEKKLFGFSFVPLMQEDGRTLPDGTHELIVHKC
EENTNLQDTTRYLKLPFSKVI-FLGNNNQTMKATKESFWITSFLCSTKLTQ

ENSGT00610000085806_3_Linker_3_5 (652, 1250)

N---GDMLD
LLKWRTHP----------DKITGCLSKLKEIDGSEIVKFLQDTLDTLFGILDENSQKYGS
KVFDSLVHIINLLQDSKFHHFKPVMDTYIESHFAGA--LAYRDLIKVLKWYVDRITEAER
QEHIQEVLKAQEYIFKYIVQSRRLFSLATGGQNEEEFRCCIQELLMSVRFFLSQESKGAG
ALSQSQAVFLSSFPAVYSELLKLFDVREVANLVQDTLGSLPTIMHVDDSLQAIKLQCIGK
TVE-SQLYTNPDSRYILLPVVLHHLHIHLQEQKDLIMCARILSNVFCLIKKNSSEKSVLE
EIDVIVASLLDILLRTILEITSRPQATSSAMRLQFQDV----------------------
----------------------TGEFVACLLSLLRQMTDRHYQQLLNSFNTKEELRDFLL
QIFTV-----FRILIRP-----EMF-PKDWTVMRLVA---NN-VIITTVLYLSDALRKNF
LNENFEYKIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKYG-----DMRVTMGCEIF
SMWQNLGEHKLHFIPALIGPFLEVTLIPQPDLRNVMIPIFHDMM-----

PF06920 // ENSGT00610000085806_3_Domain_5 (1250, 1757)

-DWEQRRSGNF
KQVEAKLIDKLDSLMSEGKGDETYRELFNTCFSPVGS-------AQKIERETWRESGVSL
IATVTRLMERLLDYRDCMKMGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHL
KAQNFTEAAYTLLLYDELLEWSDRPLREFLTYPMQTEWQRKEHLHLTIVQNFDRGKCWEN
GIILCRKLAEQYEGYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLR
NKEFVCRGHDYERLEAFQQRMLNEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPIPES
QEVLQREGVPDNIKSFYKVNHIWKFRYDRPFHKGTKDKENEFKSLWVERTSLYLVQSLPG
ISRWFEVEKREVIEMSPLENAIEVLENKNQQLKALISQCQTRQMQNINPLTMCLNGVIDA
AVNGGVSRYQEAFFVKDYILSHPEDGEKIARLRELMLEQ---AQILEFGLAVHEKFVPQD
MRPLHKKLVDQFFVMKSSFGIQEFPACIQASPVHFPNGSPRVCRNSAPASMSPDGTRVIP
RR---SPLSYPAVNRYSSSSLSSQASAEVSNITGHSESSDEVFNIQ--------------
--------PSPSTSSLSSTHSASPNVTSSAPSSARASPLLSDKHKHSRENSCLSPRDRPC
SAIYPTPVEPS-------------------------------------------------
-------QRTLFNHIGDG-ALPRSDPNLSTPEKAVNPTPSSWSLDSGKEAKNMSDGGKLI
SPPVPPRPTQTASPARHTTSV-SPSPAGRSPLK----------------GSVQSFTPSPV
EYN--SPGLSSNSPVLSGSYSSGISSLSRCSTSETSGFENQANEQSGPGPGPVPMPVPMP
--VPMPVPSF-SGSEEPVRKESKTPPPYSVYERTLRRPVPLPHSLSIPV------TSEPP
ALPPKPLAARSSHLENG-TRRTEPGPRPRPLPRKVSQL-

------------------------------

PF07653 // ENSGT00610000085806_3_Domain_0 (31, 84)

VIASFRGTVPYGLSLEIGDTVQILEKCDGW
YRGFALKNPNIKGIFPSS--YIHLKNAFVKNKGQFEMVIPTEDSVITEMTSTLRDWGTMW
KQLYVRNEGDLFHRLWHIMNEVLDLRRQVLLGHLTHDRTKDVKRHITARLDWGNEQLGLD
LVPRKEYVVVDPEDVSITELYRL---------------------------------MEHR
HRKKDTPVQASSHHLFVQMKSLMCSNLGEELEVIFSLFDSKENRPISERFFLRLNRNGLP
KAPDKPERHCSLFVDLGSSELRRDIYITVHIIRI---GRMGAGEKKSACSVQYRRPFG--
CAVLSIADLLTAETKDDLVLKVYMCNTESEWCQIHENIIKKLNARYNLTGSNAGLAVSLQ
LLHGDIE-QIRREYSSVFSHGVSITRKLGFSNIIMPGEMRNDLYITIERGEFEKGGKSVA
RNVEVTMLIVEATGQTLKDFIAFGSGE------PLASEYHSFVLYH--NNSPRWAELLKL
PIPVDKFRGAHIRFEFRHCSTKEK---GEKKLFGFSFVPLMQEDGRTLPDGTHELIVHKC
EENTNLQDAARYLSLPFSKGV-FLGNNNQAPKATKESFWITSFLCSTKLTQN---GDMLD
LLKWRTHP----------DKITGCLSKLKEIDGSEIVKFLQDTLDTLFGILDENSQKYGS
KVFDSLVHIINLLQDSKFHHFKPVMDTYIESHFAGA--LAYRDLIKVLKWYVDRITEVER
QEHIQEVLKAQEYIFKYIVQSRRLFSLATGGQNEDEFRCCIQELLMSVRFFLSQESKGSG
ALSQSQAVFLSSFPAVYSELLKLFDVREVANVVQDTLGSLPAIMHVDDALQAVKLQCISK
TVE-SQLYTNPDSRYILLPVVLHHLHMHLQEQKDLIMCARILSNVFCLIKKNSSEKSVLE
EIDVIVASLLDILLRTILETTSRPQPASSTMRLQFQDVTRAGSRRPTSAFS---------
-----------VFTDVPTVTGHSGEFVACLLSLLRQMTDRHYQQLLDSFNTKEKLKDFLL
QIFTV-----FRILIRPET------FPKDWTVMRLVA----NNVIITTVLYLSDALRKNF
LNENFDYKIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKYG-----DMRVTMGCEIF
SMWQNLGEHKLHFIPALIGPFLEVTLIPQPDLRNVMIPIFHDMM------DWEQRRSGNF
KQVEAKLIDKLDSLMSEGKGDETYRELFNSIIPLFGP---YPSLLKKIERETWRESGVSL
IATVTRLMERLLDYRDCMKMGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHL
KAQNFTEAAYTLLLYDELLEWSDRPLREFLAYPLQTEWQRKEQLHLAVIQNFDRGKCWEN
GIILCRKMAEQYESYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLR
NKEFVCRGHDYERLEAFQQRMLNEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPIPES
QEVLQREGVPDNIKSFYKVNHIWKFRYDRPFHKGTKDKENEFKSLWVERTSLYLVQSLPG
ISRWFEVEKREVMEMSPLENAIEVLENKNQQLKSLAGQCQTRQMQNINPLTMCLNGVIDA
AVNGGVSRYQEAFFVKEYILSHPEDGEKIARLRELMLEQ---AQILEFGLAVHEKFVPQD
MRPLHKKLVDQFFVMKSSLGIQDFSAYMQASPVHFSNGSPRVCRNSAPPSVSPDGARAIP
RR---SPLSYPAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQ--------------
--------PSPSTSSLSSTHSASPNVTSSAPSSARASPLLSDKHKHSRENSCLSPRERPC
SAIYPTPVEPC-------------------------------------------------
-------QRLLFNHMGDG-ALPRSDPNLSAPEKAANPTPSSWSLDSGKEAKNMSDSGKLI
SPPVPPRPTA--SPARHTASV-TLSPAGRSPLK----------------GGAQPFAASPA
EHH--CPGPASGSPALSGSCSSGISSLSRGSTSEVSSLKNAGSELPA-------------
------VRVPGGGPDEPKDRDGRPPPPYSGYERTLRRPAPPPHGPA---------AAEPP
ALPPKPPAARPGHLENG-TRRTDPGPRPRPLPRKVSQL-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------SGLAVSLQ
LLHGDIE-QIRREYTSMFTHGVSITRKLGFSNIIMPGEMRNDLYITVERGEFEKGGKSVA
RNVEVTMHVVDSGGQILRDFISFGSGE------PPASEYHSFVLYH--NNGPRWAELLKL
PIPVDKFRGAHIRCEFRHCSTKEK---GEKKLFGFSFVPLMQENGRTLPDGTHELIVHKC
EENANLQDSSRYLKLPFSKGI-FLANNSQAVKTTKESFWITSFLCSTKLTQN---GDMLD
LLKWRTHP----------DKIAGCLSKLKEIDGSEIVKFLQDTLDTLFGILDENSQKYGS
KVFDCLVHIINLLQDSKFHHFKPVMDTYIESHFAGA--LAYRDLIKVMKWHIDRVTEVEL
HEHIQEVLKAQEYIFKYIVQSRRLFSIATGGQNEEEFRCCIQELLMSVRFFLSQESKGAS
ALCQLQAVFLSSFPSVYSELLKLFDVREVANLVHDALGSLPTVMQGDESLQAVKLQSIGK
TVE-SHLYTNPDSRYILLPVVLHHLHMHLQEQKDLIMCARILSNIFCLIKKNSSEKSVLE
EIDVIVSSLLDILLRTILEITSRPQPSGSAMRLQFQDVTASERILNVEVTHGT--AFDTL
---VLFP-FVASWMDVMLQTEHKGEFVSCLLSLLRQMTDRHYQQLLDSFNTKDDLRDFLL
QIFTV-----FRILIRPE------MFPKDWTVMRLVAN----NVIITTVLYLSDALRKNF
LNENFDYKIWDSYFFLAVIFINQLCLQLEMFTPSKKKKVLEKYG-----DMRVTMGCEIF
SMWQNLGEHKLHFIPALIGPFLEVTLIPQPDLRNVMIPIFHDMM------DWEQRRSGNF
KQVEAKLIDKLDSLMSEGKGDETYRELFNSIIPLFGP---YPSLLKKIERETWRESGVSL
IATVTRLMERLLDYRDCMKMGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHL
KAQNFTEAAYTLLLYDELLEWSDRPLREFLNYPMQTEWQRKEYLHLTIIQNFDRGKCWEN
GIILCRKIAEQYESYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLR
NKEFVCRGHDYERLEAFQQRMLNEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPIPEN
QEVLQRDGIPDNI

PF06920 // ENSGT00610000085806_3_Domain_5 (1574, 1761)

KSFYKVNHIWRFRYDRPFHKGTKDKENEFKSLWVERTTLILVQSLPG
ISRWFEVEKREVVEMSPLENAIEVLENKNQQLRTLISQCQTRQMQNINPLTMCLNGVIDA
AVNGGVTRYQEAFFVKEYVLNHPEDGEKITRLRELMLEQ---AQILEFGLAVHEKFVPQD
MRPLHKKLVDQFFVMKSSLGIQEYSACVQASPIHFPNGSPRVCRNSVPVSMSPDGARVIP
RR---SPLSYPAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQ--------------
--------PSPSTSSLSSTHSASPNVTSSAPSSARASPLLSDKHKHSRENSCLSPRERPC
SAIYPTSLEAS-------------------------------------------------
-------QRMLFNHIGDG-ALPRSDSNLPGPDKAVNATPSSWSLDSGKEARNTSDSGKLI
SPPVPPRPAQTASPARHV-ASVSPSPAGRSPMKGSVQS--------------FTPS--PV
EYH--STGLISNSPVLSGSYSSGISSLSRCSTSETSGFESQGSEPPVTV-----------
--------QSYSVPEEPVRKESKTPPPYSVYERTLKRPVPLPHSLSIPP------T-DPP
ALPPKPQLGRPNNGESSSSRRTEPAPRPRPLPRKVSQL-

------------------MIVFIYSLSFFTVIASFRGTVPYGLSLEIGDTVQILEKCDGW
YRGFALKNPNIKGIFPSS--YVHLKNACV

PF16172 // ENSGT00610000085806_3_Domain_1 (90, 451)

KNKGQFEMVIPTEDSVITEMTSTLRDWGTMW
KQLYVRNEGDLFHRLWHIMNEILDLRRQVLVGHLTHDRMKDVKRHITARLDWGNEQLGLD
LVPRKEYAMVDPEDISITELYRL---------------------------------MEHR
HRKKDTPVQASSHHLFVQMKSLMCSNLGEELEVIFSLFDSKENRPISERFFLRLNRNGLP
KAPDKPERHCSLFVDLGSSELRKDIYITVHIIRI---GRMGAGEKKNACSVQYRRPFG--
CAVLSIADLLTGETKDDLILKVYMCNTESEWYQIHENIIKKLNARYNLTGSNAGLAVSLQ
LLHGDIE-QIRREYSSVFSHGVSITRKLGF

ENSGT00610000085806_3_Linker_1_3 (451, 456)

SNIIM

PF14429 // ENSGT00610000085806_3_Domain_3 (456, 652)

PGEMRNDLYITIERGEFEKGGKSVA
RNVEVTMFIVDSSGQTLKDFISFGSGE------PPASEYHSFVLYH--NNSPRWSELLKL
PIPVDKFRGAHIRFEFRHCSTKEK---GEKKLFGFSFVPLMQEDGRTLPDGTHELIVHKC
EENTNLQDTTRYLKLPFSKGI-FLGNNNQAMKATKESFCITSFLCSTKLTQ

ENSGT00610000085806_3_Linker_3_5 (652, 1250)

N---GDMLD
LLKWRTHP----------DKITGCLSKLKEIDGSEIVKFLQDTLDTLFGILDENSQKYGS
KVFDSLVHIINLLQDSKFHHFKPVMDTYIESHFAGA--LAYRDLIKVLKWYVDRITEAER
QEHIQEVLKAQEYIFKYIVQSRRLFSLATGGQNEEEFRCCIQELLMSVRFFLSQESKGSG
ALSQSQAVFLSSFPAVYSELLKLFDVREVANLVQDTLGSLPTILHVDDSLQAIKLQCIGK
TVE-SQLYTNPDSRYILLPVVLHHLHIHLQEQKDLIMCARILSNVFCLIKKNSSEKSVLE
EIDVIVASLLDILLRTILEITSRPQPSSSAMRFQFQDVTRTGFLNRESSHGSTTLSTFSV
CADTYGKVPMTSRH--------TGEFVACLLSLLRQMTDRHYQQLLDSFNTKEELRDFLL
QIFTV-----FRILIRP-----EMF-PKDWTVMRLVA---NN-VIITTVLYLSDALRKNF
LNENFDYKIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKYG-----DMRVTMGCEIF
SMWQNLGEHKLHFIPALIGPFLEVTLIPQPDLRNVMIPIFHDMM-----

PF06920 // ENSGT00610000085806_3_Domain_5 (1250, 1759)

-DWEQRRSGNF
KQVEAKLIDKLDSLMSEGKGDETYRELFNSIIPLFGP---YPSLLKKIERETWRESGVSL
IATVTRLMERLLDYRDCMKMGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHL
KAQNFTEAAYTLLLYDELLEWSDRPLREFLTYPMQTEWQRKEHLHLTIIQNFDRGKCWEN
GIILCRKIAEQYESYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLR
NKEFVCRGHDYERLEAFQQRMLNEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPIPES
QEVLQREGVPDNIKSFYKVNHIWKFRYDRPFHKGTKDKENEFKSLWVERTSLYLVQSLPG
ISRWFEVEKREVVEMSPLENAIEVLENKNQQLKTLISQCQTRQMQNINPLTMCLNGVIDA
AVNGGVSRYQEAFFVKEYILSHPEDGEKIARLRELMLEQ---AQILEFGLAVHEKFVPQD
MRPLHKKLVDQFFVMKSSLGIQEFSACMQASPVHFPNGSPRVCRNSAPASVSPDGTRVIP
RR---SPLSYPAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQ--------------
--------PSPSTSSLSSTHSASPNVTSSAPSSARASPLLSDKHKHSRENSCLSPRERPC
SAIYPTPVEPS-------------------------------------------------
-------QRMLFNHIGDG-ALPRSDPNLSAPEKAVNPTPSSWSLDSGKEAKNMSDSGKLI
SPPVPPRPTQTASPARHTTSV-SPSPAGRSPLK----------------GSVQSFTPSPV
EYH--SPGLISNSPVLSGSYSSGISSLSRCSTSETSGFENQVNEQSAPLPVPV-------
----PVPVPV-YGGEEPVRKESKTPPPYSVYERTLRRPVPLPHSLSIPV------TSEPP
ALPPKPLAARSSHLENG-ARRTDPGPRPRPLPRKVSQL-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------VIITTVLYLSDALRKNF
LNENFDYKIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKYG-----DMRVTMGCEIF
SMWQNLGEHKLHFIPALIGPFLEVTLIPQPDLRNVMIPIFHDMM-----

PF06920 // ENSGT00610000085806_3_Domain_5 (1250, 1757)

-DWEQRRSGNF
KQVEAKLIDKLDSLMSEGKGDETYRELFNSIIPLFGP---YPSLLKKIERETWRESGVSL
IATVTRLMERLLDYRDCMKMGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHL
KAQNFTEAAYTLLLYDELLEWSDRPLREFLTYPMQTEWQRKEHLHLTIIQNFDRGKCWEN
GIILCRKIAEQYESYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLR
NKEFVCRGHDYERLEAFQQRMLNEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPIPES
QEVLQREGVPDNIKSFYKVNHIWKFRYDRPFHKGTKDKENEFKSLWVERTSLYLVQSLPG
ISRWFEVEKREVVEMSPLENAIEVLENKNQQLKALISQCQTRQMQNINPLTMCLNGVIDA
AVNGGVSRYQEAFFVKDYILSHPEDGEKIARLRELMLEQ---AQILEFGLAVHEKFVPQD
MRPLHKKLVDQFFVMKSSFGIQEFPACIQASPVHFPNGSPRVCRNSAPASMSPDGTRVIP
RR---SPLSYPAANRYSSSSLSSQASAEVSNITGQSESSDEVFNMQ--------------
--------PSPSTSSLSSTHSASPNVTSSAPSSARASPLLSDKHKHSRENSCLSPRDRPC
SAIYPTPVEPS-------------------------------------------------
-------QRTLFNHIGDG-ALPRSDPNLSAPEKAVNPTPSSWSLDSGKEAKTLSDGGRLI
SPPVPPRPTQTASPARHTTP-VSPSPAGRSPLK----------------GSVQSFTPSPV
EYN--SPGLSSNSPVLSGSYSSGISSLSRCSTSETSGFENQANEQSVPGPVPMP------
MPVPMPMPSF-SGSEEPVRKESKTPPPYSVYERTLRRPVPLPHSLSIPV------TSEPP
ALPPKPLAARSSHLENG-TRRTEPGPRPRPLPRKVSQL-

------------------LYLTNLNV

PF00018 // ENSGT00610000085806_3_Domain_0 (27, 85)

LSLSVIAGFRGTVPHGLSLEIGDTVQILEKCDGW
YRGFALKNPNIKGIFPSN--YIHLKNACVKNKGQFEMVIPTEDSVITEMTSTLRDWGTMW
KQLYVRNEGDLFHRLWHIMNEILDLRRQVLVGHLTHDRMKDVKRHITARLDWGNEQLGLD
LVPRKEYAMVDPEEISITELYRL---------------------------------MEHR
HRKKDTPVPASSHHLFVQMKSLMCSNLGEELEVIFSLFDSKENRPISERFFLRLNRNGLP
KCPEKPERHCSLFVDLGSSELRKDIYITVHIIRI---GRMGAGEKKNACNVQYRRPFG--
CAVLSIADLLAGDSKDDLVLKVYMCNTESDWYQIHENIIKKLNARYNLTGSNAGLAVSLQ
LLHGDIE-QIRREYTSMFTHGVSITRKLGFSNIIMPGEMRNDLYITVERGEFEKGGKSVA
RNVEVTMHVVDSSGQILKDFISFGSGE------PPASEYHSFVLYH--NNGPRWAELLKL
PIPVDKFRGAHIRCEFRHCSTKEK---GEKKLFGFSFVPLMQENGRTLPDGTHELIVHKC
EENTNLQDSSRYLKLPFSKGI-FLGNNSQAVKTTKESFWITSFLCSTKLTQN---GDMLD
LLKWRTHP----------DKIAGCLSKLKEIDGSEIVKFLQDTLDTLFGILDENSQKYGS
KVFDCLVRSIGRLETSCNIGLVVICKTLCCGFFFQCFLYYSRDLIKVLKWHIDRVTEVEL
HEHIQEVLKAQEYIFKYIVQSRRLFSIATGGQNEEEFRCCIQELLMSVRFFLSQESKGAN
ALSQLQAVFLSSFPSVYSELLKLFDVREVANLVHDALGSLPTVMHGDESLQAVKLQSIGK
TVE-SHLYTNPDSRYILLPVVLHHLHMHLQEQKDLIMCARILSNIFCLIKKNSSEKSVLE
EIDVIVNSLLDILLRTILEITSRPQPSGSAMRLQFQDV----------------------
----------------------TGEFVSCLLSLLRQMTDRHYQQLLDSFSTKEDLRDFLL
QIFTV-----FRILIRP-----EMF-PKDWTVMRLVA---NN-VIITTVLYLSDALRKNF
LNENFDYKIWDSYFFLAVIFINQLCLQLEMFTPSKKKKVLEKYG-----DMRVTMGCEIF
SMWQNLGEHKLHFIPALIGPFLEVTLIPQPDLRNVMIPIFHDMM------DWEQRRSGNF
KQVEAKLIDKLDSLMSEGKGDETYRELFNSIIPLFGP---YPSLLKKIERETWRESGVSL
IATVTRLMERLLDYRDCMKMGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHL
KAQNFTEAAYTLLLYDELLEWSDRPLREFLNYPMQTEWQRKEYLHLTIIQNFDRGKCWEN
GIILCRKIAEQYESYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLR
NKEFVCRGHDYERLEAFQQRMLNEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPIPEN
QEVLQRDGIPDNI

PF06920 // ENSGT00610000085806_3_Domain_5 (1574, 1761)

KSFYKVNHIWRFRYDRPFHKGTKDKENEFKSLWVERTTLILVQSLPG
ISRWFEVEKREVVEMSPLENAIEVLENKNLQLRTLISQCQTRQMQNINPLTMCLNGVIDA
AVNGGVARYQEAFFIKEYVLNHPEDGEKITRLRELMLEQ---AQILEFGLAVHEKFVPQD
MRPLHKKLVDQFFVMKSSLGIQEFSACVQASPIHFPNGSPRVCRNSIPVSMSPDGARVIP
RR---SPLSYPAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQ--------------
--------PSPSTSSLSSTHSASPNVTSSAPSSARASPLLSDKHKHSRDNSCLSPRERPC
SAIYPTPSETS-------------------------------------------------
-------QRMLFNHVGDG-ALPRSDSNLPGPDKAVNTTPSSWSLDSGKEARNTSESGKLI
SPPVPPRPAQTASPARHIATV-SPSPAGRSPMK----------------GSVQSFTPSPV
EYH--SSGLISNSPVLSGSYSSGISSLSRCSTSETSGFESQGSEQAV---------TVP-
--------SY-NVSEEPVRKESKTPPPYSVYERTLKRPVPLPHSLSIX-------ATDPP
ALPPKPQLVRPNNLENS-SRRTEQVPRPRPLPRKVSQL-

-----------------NCDPPPHSKWYCAIIASFRGTIPYGLSLEIGDTVQILEKCDGW
YRGFALKNPNIKGIFPSS--YVHLKNACV

PF16172 // ENSGT00610000085806_3_Domain_1 (90, 451)

KNKGQFEMVIPTEDSVITEMTSTLRDWGTMW
KQLYVRNEGDLFHRLWHIMNEILDLRRQVLVGHLTHDRMKDVKRHITARLDWGNEQLGLD
LVPRKEYAMVDPEDISITELYRL---------------------------------MEHR
HRKKDTPVQASSHHLFVQMKSLMCSNLGEELEVIFSLFDSKENRPISERFFLRLNRNGLP
KAPDKPERQCSLFVDLGSSELRKDIYITVHIIRI---GRMGAGEKKNACSVQYRRPFG--
CAVLSIADLLTGETKDDLILKVYMCNTESEWYQIHENIIKKLNARYNLTGSNAGLAVSLQ
LLHGDIE-QIRREYSSVFSHGVSITRKLGF

ENSGT00610000085806_3_Linker_1_3 (451, 456)

SNIIM

PF14429 // ENSGT00610000085806_3_Domain_3 (456, 652)

PGEMRNDLYITIERGEFEKGGKSVA
RNVEVTMFIVDSSGQTLKDFISFGSGE------PPASEYHSFVLYH--NNSPRWSELLKL
PIPVDKFRGAHIRFEFRHCSTKEK---GEKKLFGFSFVPLMQEDGRTLPDGTHELIVHKC
EENTNLQDTTRYLKLPFSKGI-FLGNNNQAMKATKESFCITSFLCSTKLTQ

ENSGT00610000085806_3_Linker_3_5 (652, 1250)

N---GDMLD
LLKWRTHP----------DKITGCLSKLKEIDGSEIVKFLQDTLDTLFGILDENSQKYGS
KVFDSLVHIINLLQDSKFHHFKPVMDTYIESHFAGALAY--RMI-KCLLFFIF----LDG
LTFKNCIFKAQEYIFKYIVQSRRLFSLATGGQNEEEFRCCIQELLMSVRFFLSQESKGSG
ALSQSQAVFLSSFPAVYSELLKLFDVREVANLVQDTLGSLPTILHVDDSLQAIKLQCIGK
TVE-SQLYTNPDSRYILLPVVLHHLHIHLQEQKDLIMCARILSNVFCLIKKNSSEKSVLE
EIDVIVASLLDILLRTILEITSRPQPSSSAMRFQFQDVTRTGFLNRESLHDSSTLSTFSF
CADTYGKVPMTGRHTISKHRSHSGEFVACLLSLLRQMTDRHYQQLLDSFNTKEELRDFLL
QIFTV-----FRILIRP-----EMF-PKDWTVMRLVA---NN-VIITTVLYLSDALRKNF
LNENFDYKIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKYG-----DMRVTMGCEIF
SMWQNLGEHKLHFIPALIGPFLEVTLIPQPDLRNVMIPIFHDMM-----

PF06920 // ENSGT00610000085806_3_Domain_5 (1250, 1759)

-DWEQRRSGNF
KQVEAKLIDKLDSLMSEGKGDETYRELFNSIIPLFGP---YPSLLKKIERETWRESGVSL
IATVTRLMERLLDYRDCMKMGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHL
KAQNFTEAAYTLLLYDELLEWSDRPLREFLTYPMQTEWQRKEHLHLTIIQNFDRGKCWEN
GIILCRKIAEQYESYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLR
NKEFVCRGHDYERLEAFQQRMLNEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPIPES
QEVLQREGVPDNIKSFYKVNHIWKFRYDRPFHKGTKDKENEFKSLWVERTSLYLVQSLPG
ISRWFEVEKREVVEMSPLENAIEVLENKNQQLKTLISQCQTRQMQNINPLTMCLNGVIDA
AVNGGVSRYQEAFFVKEYILSHPEDGEKIARLRELMLEQ---AQILEFGLAVHEKFVPQD
MRPLHKKLVDQFFVMKSSLGIQEFSACMQASPVHFPNGSPRVCRNSAPASVSPDGTRVIP
RR---SPLSYPAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQ--------------
--------SWELWPAAT----RSGSLLQTGAAPLPSSPLLSDKHKHSRENSCLSPRERPC
SAIYPTPVEPS-------------------------------------------------
-------QRMLFNHIGDG-ALPRSDPNLSAPEKAVNPTPSSWSLDSGKEAKNMSDSGKLI
SPPVPPRPTQTASPARHTTSV-SPSPAGRSPLK----------------GSVQSFTPSPV
EYH--SPGLISNSPVLSGSYSSGISSLSRCSTSETSGFENQVNEQSVPLPV---------
--PVPVPVPV-YGGEEPVRKESKTPPPYSVYERTLRRPVPLPHSLSIPV------TPEPP
ALPPKPLAARSSHLENG-ARRTDPGPRPRPLPRKVSQL-

------------------------------V

PF07653 // ENSGT00610000085806_3_Domain_0 (32, 82)

IASFRGTVPYGLSLEIGDTVQILEKCDGW
YRGFALKNPNIKGIFPSS--YVHLKNACVKNKGQFEMVIPTEDSVITEMTSTLRDWGTMW
KQLYVRNEGDLFHRLWHIMNEILDLRRQVLVGHLTHDRMKDVKRHITARLDWGNEQLGLD
LVPRKEYAMVDPEDISITELYRL---------------------------------MEHR
HRKKDTPVQASSHHLFVQMKSLMCSNLGEELEVIFSLFDSKENRPISERFFLRLNRNGLP
KAPDKPERHCSLFVDLGSSELRRDIYITVHIIRI---GRMGAGEKKNACSVQYRRPFG--
CAVLSIADLLTGETKDDLILKVYMCNTESEWYQIHENIIKKLNARYNLTGSNAGLAVSLQ
LLHGDIE-QIRREYSSVFSHGVSITRKLGFSNIIMPGEMRNDLYITIERGEFEKGGKSVA
RNVEVTMFIVESGGQTLKDYISFGSGE------PPASEYHSFVLYH--NNSPRWSELLKL
PIPVDKFRGAHIRFEFRHCSTKEK---GEKKLFGFSFVPLMQEDGRTLPDGTHELIVHKC
EENTNLQDTTRYLKLPFSKGI-LLGNSNQTMKATKESFWITSF-CSTKLTQN---GDMLD
LLKWRTHP----------DKITGCLSKLKEIDGSEIVKFLQDTLDTLFGILDENSQKYGS
KVFDSLVHIINLLQDSKFHHFKPVMDTYIESHFAGA--LAYRDLIKVLKWYVDRITEAER
QEHIQEVLKAQEYIFKYIVQSRRLFSLATGGQNEEEFRCCIQELLMSVRFFLSQESKGSG
ALSQSQAVFLSSFPAVYSELLKLFDVREVANLVQDTLGSLPTIVHVDDSLQAVKLQCIGK
TVE-SQLYTNPDSRYILLPVVLHHLHMHLQEQKDLIVCARILSNVFCLIKKNSSEKSVLE
EIDVIVASLLDILLRTILEITSRPQPSGSSMRLQFQDV----------------------
----------------------T-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------MLD
LLKWRTHP----------DKIAGCLSKLKEIDGSEIVKFLQDTLDTLFGILDENSQKYGS
KVFDCLVHIINLLQDSKFHHFKPVMDTYIESHFAGA--LAYRDLIKVLKWHIDRVTEVEL
HEHIQEVLKAQEYIFKYIVQSRRLFSIATGGQNEEEFRCCIQELLMSVRFFLSQESKGAS
ALCQLQAVFLSSFPSVYSELLKLFDVREVANLVHDALGSLPTVMQGDESLQAVKLQSIGK
TVE-SHLYTNPDSRYILLPVVLHHLHMHLQEQKDLIMCARILSNIFCLIKKNSSEKSVLE
EIDVIVSSLLDILLRTILEITSRPQPSGSAMRLQFQDV----------------------
----------------------TGEFVSCLLSLLRQMTDRHYQQLLDSFNTKEDLRDFLL
QIFTV-----FRILIRPE------MFPKDWTVMRLVAN----NVIITTVLYLSDALRKNF
LNENFDYKIWDSYFFLAVIFINQLCLQLEMFTPSKKKKVLEKYG-----DMRVTMGCEIF
SMWQNLGEHKLHFIPALIGPFLEVTLIPQPDLRNVMIPIFHDMM-----

PF06920 // ENSGT00610000085806_3_Domain_5 (1250, 1759)

-DWEQRRSGNF
KQVEAKLIDKLDSLMSEGKGDETYRELFNSIIPLFGP---YPSLLKKIERETWRESGVSL
IATVTRLMERLLDYRDCMKMGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHL
KAQNFTEAAYTLLLYDELLEWSDRPLREFLNYPMQTEWQRKEYLHLTIIQNFDRGKCWEN
GIILCRKIAEQYESYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLR
NKEFVCRGHDYERLEAFQQRMLNEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPIPEN
QEVLQRDGIPDNIKSFYKVNHIWRFRYDRPFHKGTKDKENEFKSLWVERTTLILVQSLPG
ISRWFEVEKREVVEMSPLENAIEVLENKNQQLRTLISQCQTRQMQNINPLTMCLNGVIDA
AVNGGVTRYQEAFFVKEYVLNHPEDGEKITRLRELMLEQ---AQILEFGLAVHEKFVPQD
MRPLHKKLVDQFFVMKSSLGIQEYSACVQASPIHFPNGSPRVCRNSIPVSMSPDGARVIP
RR---SPLSYPAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQ--------------
--------PSPSTSSLSSTHSASPNVTSSAPSSARASPLLSDKHKHSRENSCLSPRERPC
SAIYPTSLEASQTANSCFAKWNAASVPHSTRDSIREAEEHVCPASTLSETRLAAKSPNLS
LPSVSQERRMLFNHIGDG-ALPRSDSNLPGPDKAVNATPSSWSLDSGKEARNTSDSGKLI
SPPVPPRPAQTASPARHI-ASVSPSPAGRSPMKVLAFC--------------KSTS--SV
GQIICAVGYII------------------CI-----------------------------
------------------------------------------------------------
---------------------------------------