Query Results 

-----------------------------------------------MGPARP-------
------ALLLLLLLLLLLLDTGAWAQDEVLENVS-PSCPKEATRFKHLRKYMYNYEAESS
SGVPGTADSRSITKINCKVELEVPQLCNFILKTSQCTLKEVYGFNAEGKPLLKKTKNSEE
FAAAMSKYEL-RLGVPEGKKVFLYPEKGEPKHILNIKRGIISALLVPPETEEDKQVL---
FTEND---CDRRLRSKPQ------E---------------LFKM------LTLQPHAQVR
P

PF01347 // ENSGT00590000083139_0_Domain_0 (302, 673)

LSTLLSSSQSC-QYTLDSKRKHVSEAICKEQHLLLPFSYKNKYGMMTHITQTLKLEDTP
--KTNSRFFNAG-TEKVGLAFESTKSTLPPKQ-AEAVLTTLQELKKLSISEQNAQRANLF
KKLVTELRGLDEEAVKSLLPQLIEVSS--PITLQALVQCGQPQCYTHILQWLKSEKAHPL
LIDVVTYLVALIPEPSTQRLREIFNTAREQQSRATLYALSHVVNNYHP-MTQEMTQDL-Q
DIADYLLEQIRNECTGDEDHTYLILRVIGNMGRTMEQVMPRLKSSVLKCIRSAKPSLLIQ
KAAIQALRKMELRDEVRGILLQTFVDGAAPVDKRLAAYLMLMRGPSQADINKIARILPRE
QNEQVKNFVASH

ENSGT00590000083139_0_Linker_0_3 (673, 709)

IANILNSEELDIQDLKNLVKEALKESQ-LPTVMDFR

PF09172 // ENSGT00590000083139_0_Domain_3 (709, 1017)

KFSRNYHLSKSV
SLPSLD-PVSAKIEGNLIFDPNNYLPKESMLKTTLTVFGFAPTDLVEIGLEGKGFEPTLE
ALFGKKGFFPDSVNKALYWVNGRVPDHVSKVLVDHFDYIKEDKHEQDMVNGIMPIVEKLI
NDLKSKEIPEARAYLRILGEELGFVRLQDLQLLGRLLLSGVQTLQGIQHLVSDQAIREGS
KSDLFLHYIFMDNAFELPTGVGSQLQVSLSGVITPGTKAGVKLELA-NMQADLVVKPSMT
VEFATNMGIILPGFARSGVQMNTNFFHESGLEARVTLKTGQLKFIIPSPRRPVKLF

ENSGT00590000083139_0_Linker_3_5 (1017, 1044)

SGSN
TLHLVSTT----KTEVIPPLIEN

PF06448 // ENSGT00590000083139_0_Domain_5 (1044, 1156)

RQSWSTCRPFVTGLSYCTSG-AYSNASSTESTSYYPL
TGDTSFELELKPTGEVEQYSASATYELQREERALVDTLKFIIQAEGVKHTEATMMFKYNR
QSRTLFSEIQIPDLN

ENSGT00590000083139_0_Linker_5_6 (1156, 4658)

VDLGTVLRVSDESAQDKKSYKLTLDIQNKKITEVALMGHISYDTK
EESKIKGVISIPRLQAEARSEILTRWSPTKLLLQMDSS--ATAYGSTVSKRLAWRYDEEK
IEFEWNTGTNVDTKKVASNFPV----DLSDFYRAFLLHASSLPDNRVPQTDMTFRQMGSK
LIVATNSWLQKASESLPLAQTLQDHLSGLTELSLQKMRFPTFQVPENLFLKSDGRVKYTL
NKNSVKIEIPLPFGGKSSKDLKMLETIRTPALNFKSVGFQLPSQEFQVPTFTIPKLYQLR
VPLLGVLDLSTNIYSNLYNWSASYTGGNTSR-D--HYSLQARYHMKADSVIDMFSYSIQG
SGETAYDQRNMLTLACDGSLRHKF-LDSKIKFSHVEKVGNNPASKGF---LTFDASSAWG
PQMSASIHFDSKKKQHLYVKDVKIDGQFRASSFYANGIYDLSCQRDSTTGQLSGESNLRF
NSSYLQGTNQITGRYKDGTLSLTSTSDLQDGIFKNTASLKYENYELTVKSDSNGKYEDFS
TFNKVDLTFSKQNALLRSEYQADYKSLRFFTLLSGSLNSHGIELNADILGTDKINTGAHK
ATLRIARDGLSTSATTSLKYSPLLLENELNAELDLSGASMKLTANGRFREHNAKFSLDGK
AALTEVSLGSTYQAMILGVDSKNIFNFKISREGLKLSNDMMGSYAEMKLDHSNSLNIAGL
SLDLSSKLDNVYSTDKFYKQNFNLQLQPFSLVTTLNNDLRYSALDLTSNGKLRLEPLKLN
MAGNLKGAYQNDEIKHIYTISYADLS-ASYKADT---VARVQGVEFSHRLNTDIAGLASS
IDISTNYNSDSLHFSNVFRSAMAPFTVAIDAHTNGNGKLALWGEHTGQLYSKFLFKAEPL
ALTFSHDYKGSTSH-LMSSKSISTALDHKVSVLLTPAEQTSTWKLKTQLNNNEYSQDFEA
YNTKDKIGVELSGRALADLTVLDSPIKVPFLLREPVNVIDALEMKDAIDKPQEFTIVAFV
KYDKNQEVHTISLPFSETLPEYLERNRIVIITALQTIQKELKRINIDQFMRKYRAALNRL
PQQVNDYLNALNWERQVSIAKEKLNTFTENYRITENDLQIALDNAKINFNEKLSQLQTYV
IQFDQYIKDNYDLHDFKTAIAKIIDQIIEKWKILNEHYHICVHLVKTINDLYEFIENIDF
DKTGSSVASWIQNVDTKYQVRIQIQEKLQQLNTHIQNTDIEDIATVLKQRVKDIDVRVLL
DQLRTTISFQRIKDIIEHVKYFVTNLIEEFEVTEKINAFRAIVHELIRKYEVDQQIQVLM
DKSVQLAHKYKLKETVQKLSNVLQQVEIKEYYERLVGFIDDAIKQLKALSFKKFIEEVNR
LLDMLVKKLKSFNYNQFVNETNNKIHEMTQRINGEIQALELPQKAEAL-KLFVEDIKAMV
AIYWEKLKDTKITLFIDWLQDALNSASLVHMKARFQETLEDLRDRIYQMDLQRELERYLS
LVGQVYNTLVTYITDWWILAAKNFTDFAEQYSIQDWAEKVKSLVERGFTVPKIQTILGTM
PAFEVSLHALQEATFQTPDFIVPLTDLRIPSVQINFKELKDIKIPSRFSTPEFTILNTFH
IPSFTIDLVEIKAKIIRTIDQMLISELQWPLPEVYLRDLKMGDIPLALLTLPDFHLPKIT
IPEVMIPNLNLKDFQVPDLQIPDFQLPHISHTIGIPTFGKLNSILKVQSPLFTLDANANI
QNVTS-SEHKAEIAASITAKGESKLEVLNFDFQANAQLSDPKI--NPLVLKESMIFSSKY
MRTKHESEILFSGNAIEGKSDTMASLHTEKNTLEFNNGVIVKINNQLKLESHTKYFHKLN
IPKLDLSSKVDLNNDIKTLLEAGHLTWTSSGIGSWKLACLNFSDEGIHESQISFTVEGPI
TSFGLSNNISSKHLRVNQKIAYESGFLDSSRFEIKSEVESQHVGHSILTANGIALLKEGK
TEITGIHNAHLNGKVIGTLKNSLFFSAQPSEITATTKNEGNLKVSFPLKLVGKIDFLNNY
AMFLSPHAQQASWQASARFNQYKYHQNFSAVNNGHSMEAHVQINGDANLDFLNIPLTIPE
IN--LPYTTLTTPS-LKDFSIWEETGLKEFLKTTKQSFDLSVKARYKKNKDRHSIAIPLG
VFFEFINQNINSFDRHFEKVRDDALDFLTTSYNEAKSKFDEYEVERSLNKLPRTFQTPRY
TLPV---INMEVSPFTVEMSASSHVIPKVISTPNVTIPGSGFYVPSHTFVLP-SIELPVL
RAPRNLLKVPLPDFKELSTINNIFIPALGNITYDFSFKSSAITLNTNIGLYNQSDIVAHF
LSSSSFVIDALQYKLEGTSSLTRKRGLKLATALSLS-NKFVEGSHDSTISLIEKNLEASV
TTTAKIHVPVLRLNFKQELNGNTKSKPTVSSSTELKYDFNSPKLYYTAKGAVDHKLSLES
L-----TSYFSIESSTKGDVKGSVLS-REYLGTIASEASMYLNSKGTRSSVKLQGASKVD
NIWNLEVKENFAGEANLRRIYAIWEHNTENYLQLQGLFFTQGEHASKATLELSPWTMSAL
VQGHASQLSSLLDIPYIDQEVTLNANTKNQKVSWKSEIQIYSGSLQNNIQLSNTQEEARL
DIAGSLEGS--NLEHIVLPVYDKSLWDLLK---------RQYLHVSTALVYTKNPNGYLL
SVPVQELADKFI--IPGLKLNDLNSVFS-----------------------------RMS
PFALNLPTLPKIKFPEVDVLTKYSESENSSFPFFEITVPAAQFIVTPFTLPKSISIGSAV
LDLNEVANKIGGFELPTIIMPEQTIQIPSIKFSIPAGIWIPIFGELTARFRVASPPYNAT
WSAGLKNKADHIETFLDSTCSSTLKFLEYDLKAVDIYKFEDYSFIYKSNNTFVHRDFSVL
YKEEGKYKGLQDLEMQAVLDITCPVFSDLQLHYQTYSK-IQTFWAAYPAIDTVGLNLGEK
G-NHSIVKN---PYFYPQSSAEKKLIILITEWR--HK-PDGDIQIKFNWDEEVAS-RLLS
SLKDSVPKATETFYDYVNKYHQEYTGLSLTD--------------QAYQGAMRQIDEMD-
-MGFQRA------------DKTQNLYQELL-AQESQASFQTIKEKAFDSLIQIIKGYHRA
IKHLIDSFIDILKFSRFHLPGKAEMSTIDELNSMVMKEVGKMLSQVCSNIQNGLDKLLSY
VQDLVGRTELIKDLQIKLPFHSTSSK---------LKDAIPDLREQLK----SLSGEIQE
TLIDYLSVNT-TETLSVLGIVLQSFVFNEIEKDIEILKELNFTDLVNEILQEKD-NFKDY
VLYVFQNLKESLDFILSSFN----EFIQDQLQDSSQNLQQVHQYIKALREEYFDPSTVGW
MVKYYKLEEKVMDLIRNFLIALKDFHSKYTSSATGFTSQLSNQVKQFVDRAFQEYVSILT
DADGKGKEKIEELSTTAQEIIKSWATAMKKIISDYQH

PF12491 // ENSGT00590000083139_0_Domain_6 (4658, 4714)

QFRSKLQDFSDQLSDYYEKFIAE
ATRLIDLSIQSYHIFLRYITKFLTELQS-TTVNDVSPHMKFAPGELTIIF----------
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----MSRY

PF01347 // ENSGT00590000083139_0_Domain_0 (189, 673)

EL-KLAIPEGKQVFLYPEKDEPTHILNIKRGIISALLVPSETEEAKQVL---
FLDTVYGNCSTDFTVKTRKGNVATEISTERD----LGRCDRFKPISTSTSPLALIKGITR
PLSTLISSSQSC-QYTLDAKRKHVAEAICKEQHLFLPFSYKNKYGMMTQVTQTLKLEDMP
--KINSRFFGEG-TNKMGLAFESTKSTSPPKQ-AEAVLKTLQELKKLTISEQNSQRANLF
NMLVTELRGLSDEAVTSLLPQLIEVSS--PITLQALVQCGRPQCYTHILQWLSSVHANPL
LIDVVTYLVALIPEPSAQQLREIFNTAREQRSRATLYALSHVVNNYHK-TNPTGTQEL-L
DVANYLMEQIQDDCTGNEDYTYLILRVIGNMGQTMERLTPELKSSILKCVQSTKPSLMIQ
KAAIQALRKMELKDKDQEVLLQTFLDSASPGDKRLAAYLMLMRDPSQADINTIVQLLPRE
QNEQVKNYVASH

ENSGT00590000083139_0_Linker_0_3 (673, 709)

IANILNSEELYIQDLKRLVKEALKESQ-LPTVMDFR

PF09172 // ENSGT00590000083139_0_Domain_3 (709, 1017)

KFSRNYQLSKSV
SLPSLD-SASAKIEGNLIFDPNNYLPKESMLKTTLTVFGFAPADLFEIGLEGKGFEPTLE
ALFGKQGFFPDSVNKALYWVKGQVPDGVSKVLVDHFGYTKDDKREQDMVKGMMLSVEKLI
KDLKSKEVPEARAYLRILGEELGFARLHDLQLLGKLFLMGARTVQGIPQVIG-EIFREGS
KNDIFLHYIFADYAFELPTGAGLQFQMSSSGVITPGAKAGVKLEVA-NMEAELVAKPSVS
VEIVTNMGIIIPDFARSGVQMHTNIFHESGLEARVALKAGQLKFIIPSPKRPVKLF

ENSGT00590000083139_0_Linker_3_5 (1017, 1044)

SGGN
TLYLVSTT----KTEVIPPLIEN

PF06448 // ENSGT00590000083139_0_Domain_5 (1044, 1156)

RQSWSTCKPFFTGLNYCTSG-AYSNASSTDSASYYPL
TGNTRLELELRPTGEIEQYSVSATYELQREDRALVDTLKFITQAEGVKQTEATMTFKYNR
QSMTLSSEVQIPDFDVDLGTILRVHDESTKGKKSYRLTLDIQNKKITEAALMGHLSCDTK
EEGKIKGVISIPRLQAEARSEILTHWSPAKLLLQMDSS--ATAYGSTVSKRLAWHYDEEK
IEFEWNTGTNVDTKKMASNFPD-----ISDFLWSLSLNVVGLLDTRIPPTDMTLWYMGSK
LIDTTHSWLQQASESLPYAQTLQDHLSGLKELNLQNMELPDFHIPENLFLKSDGRVKYTL
NKNSLKIEIPLPFGGKSSRDLKMLETVRTPALQFKSVGFHLPSQEFQVPTFTIPELYQLQ
VPLLGVLDLSTNVYSNLYNWSASYTGGNTST-D--HFSLRASYHMKADSVVDLLSYNVQG
SGETTYDHKNTLTLSCDGSLRHKF-LNSNIKFSHVEKVGNNPVSKGL---LTFDASSAWG
PQMSASVHLDSKKKQHLFVKEVKIDGQFRVSSFYAKGTYGLSCQRDPNTGRLNGESNLRF
NSTYLQGTNQITGRYEDGTLSLTSTSDLQSGIIKNTASLKYENYELTLKSDTNGKYKNFA
TSNKMDMTFSKQNALLRSEYQANYESLRFFSLLSGSLNSQGLELNADILGTDKINSGAHK
ATLRIAQDGVSTSAMTSLKYSPLVLENELNADLGLSGASMKLTTNGRFREHNAKFSLDGK
AALTELSLGSAYQAMILGVDSKNLFNFKISQEGLTLSNDMMGSYNEMKLDHTNSLNIAGL
SLDFSSKLDNIYSSDKFYKQTFNLQLQPYSLVTTINNDLKYNALDLTNNGKLRLEPLKLN
VAGNLKGAYGNNEIKHIYTIAYAALS-ASYKADT---VAKVQGVEFSHRLNTDIAGLASA
VDISTNYNSDSLHFSNVFHSVMAPFTMTIDAHTNGNGKLALWGEHTGQLYSKFLLKAEPL
AFTFSHDYKGSTSHHLMSRKSVSTTLEHKASALLTPAEQMGTWKLKTQFNNNEYSQDLEA
YNTKDKIGVELSGRALADLTLLDSPIKVPFLLSEPVNVIDALEMKDAIETPQEFTIVAFV
KYDKNQDVHTISLPFLETLQEYFERNLQTVIIILEHMQRDLKHININQFVRKYRAALGKL
PQQVDDYLNSFNWERQVSHAKEKLTALTKKYRITENDIQIALDDAKINFNEKLSQLQTYV
IQFDQYIKDNYDLHDLKIAIANIIDRIIEKLRSLDEDYHIRVNLVKTIHDLHLFIENIDF
NKTGSSTASWIQNVDTKYRIRIQIQEKLQQIKRHIQNIDMQHLAGKLKQYVEATDVRVLL
DQLGTTISFERINDILEYVKYFVINLIGDFEVAEKINAFRAKVHELIGRYEIDQQIQVLM
DKSVELAHQFKLKETTQKLSHVLQQVKIKDYFEKLIGLIDDAVKQLGELSFKTFIEDVNK
FLDMLIKKLRLFNYHQFVNETNNKIHEVTQRLNGEIQALELPQKAKAL-KLFLEDTKATV
AVYLESLQDTRITLIIDWLQDALSSASFAHIRAKFCETLEDTRDRMYQMDIQQELQRYLS
LVGQVYSTLVTYISDWWTLAAKNLTDFAEQYSIQDWAKRVKALVERGFTVPEIKTILGTV
PAFEVSLQALQKATFQTPDFIVPLTDLRIPSVQINFKELKDIKIPSRFSTPEFTLLNTFH
IPSFTIDFVEIKVKIIRTIDQVLNSELQWPVPELYLRDLKVEDIPLVRITLPDFHLPEIA
IPEFVIPNLNLSDFQVPDLHIPEFQLPHISHTIEVPTFGKLYGILKIQSPLFTLDANADI
QNETT-SANEAGIAASITAKGESRLEVLSFDFQAKAQLSTPTI--NPLALKESVKFSSKY
LRTQHDSEMLFFGNTIEGKSNTVASLHTEKNTLELSNGVIVKINNQLTLDSNTKYFHNLN
IPKLDFSSQADLRNEVKTLLEAGHVAWTSSGKGSWKWACPQFSDEGTHESQISFTMEGPL
TSFELSNKINSKHLTVNQNLVHESGFLNFSKLEIQSQVESQHVGRSVLTAKGTALFGEGK
AELTGRHDAHLNGKVIGTLKNSLFFSAQPFEITVSTNNEGNLKVSFPLRVTWKIDFLNNY
ALFLSPSAQQAGWQVSARYNQYKYNQNFSAENNENIMEARVGINGEANLDFLNISLTIPE
ML--LPYTTITTPP-LKDFSLWEKTGLKELLKTTKQSFDLSVKAQYKKNKHKHSITNPLA
VLCEFISQNIKSFDRHFEKAGNDALDFVTKSYKEAKIKFDKYKAEKSHNELPRTFQIPGY
TVPV---VNVEVSPFTVEMSAFGYVIPKAVSMPSFTISGSDIRVPSYTLTLP-SLELPDL
HVPRHL-KLSLPDFKELCTITHIFIPAMGNITYDFSFKSSVITLNTNAELFNQSDIVAHL
LSSSSSVIDALQYKLEGTTRLTRKRGLKLATALSLS-NKFVEGSHNSIVSLTKKNMEASV
VTAAKVQIPILRMNFKQELNGNSKSKPTVSSSMEFKYDFNSPMLYSTAKGAADHKLSLES
H-----TSYFSIESSTKGGVKGSVLS-REYSGTIASEASTYLNSKSTRSSVKLQGTSKID
DIWNLEVKENFAGEATLQRIYSLWEHSTKNHLQLEGLFFTNGEHTSKATLELSPWEMSAL
VQVHASQPNSFLDIPYLGQEVALNANTKNQKIRWKSEARVHSGSLHSHVELSNDQKEAHL
DIAGSLEGHLSFLKNIILPVYDKSLWDFLKLDVTTSMGRRQHLRVSTALVYTKNPNGYSF
SIPVKVLADEFI--IPGLKLNDLNSVLVMPAFYVPFTDLQVPSYKLDFREIKMYKKLRTS
SFALSLPTLPKVKFPEVDVLTKYSQPEDSLVPFFEITVPESQLTVSQFTLPKSVSVGGAV
LDLNEVAKKIADFELPTIIMPEQTIEIPSIKFSVPAGIFIPSFGALTARFGVASPLYNAT
WSASLKNKADHLETVLDSTCSSTIQFLEYDLNGKKYPASSP--RYCA----FSMRVMSK-
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-----------------------------------------------MGRPRPALL----
AL---PALL-LLLAGARAEKE----M---LENVS-VVCPRDATR

PF01347 // ENSGT00590000083139_0_Domain_0 (105, 673)

FKHLRKYTYNYEAESS
SGVPGTADSRSATRINCKVELEVPQLCSFILKTSQCTLKEVYGFNPEGRALLKKTKNSEE
FAAAMSRYEL-KLAIPEGKQVFLYPEKDEPTHILNIKRGIISALLVPPETEETKQVL---
FLDTVYGNCSTHFTVKTRKGNVATEISTERD----LGQCDRFKPIRTGISPLALIKGMTH
PLSTLISSSQSC-QYTLDAKRKHVAEAICKEQHLFLPFSYKNMYGMGVQVTQTLKLEDTP
--KINSRFFGEG-TKKVGLAFESTKSTSPLKQ-AEAVLKTLQELKKLTISEQNIQRANLF
HKLVTELRGLSDEAVTSLLPQLIEVSS--PITLQALVQCGQPQCSTHILQWLKRVHANPL
LIDVVTYLVALIPEPSAQQLREIFNMAREQRSRATLYALSHAVNNYHK-TNPTVTQEL-L
DIANYLMEQIQDDCTGDEDYTYLILRVIGNMGQTMEQLTPELKSSILNCVQSTKPSLMIQ
KAAIQALRKMEPKDKDQEVLLQTFLDDASPGDKRLAAYLMLMRSPSQADINKIVQLLPRE
QNEQVKNFVASH

ENSGT00590000083139_0_Linker_0_3 (673, 709)

IANILNSEELDIQDLKKLVKEALKESQ-LPTVMDFR

PF09172 // ENSGT00590000083139_0_Domain_3 (709, 1017)

KFSRNYQLSKSV
SLPSLD-PASAKIEGNLIFDPNNYLPKETMLKTTLTAFGFASADLFEIGLEGKGFEPTLE
ALLG------NSVNKALYWVNGQVPDGVSKVLVDHFGYTKEDKREQDMVNGMMFSVQKLI
EDLKSKEVPEARAYLRILGEELGFAKLHDLQFLGKLLLMGARTLQGIPQMIG-EVIRKGS
KNDFFLHYIFIENAFELPTGAGLQLQISSSGVTAPGIKAGVKLEVA-NMQAELVAKPSVS
VEFVTNMGIIIPDFARSGVQMNTNFFHESGLEARVALKAGQLKFIIPSPKRPVKLL

ENSGT00590000083139_0_Linker_3_5 (1017, 1044)

SGSN
TLHLVSTT----KTEVIPPLIEN

PF06448 // ENSGT00590000083139_0_Domain_5 (1044, 1156)

RQSLSVCKQLFTGLNYCTSS-AYSNASSTDSAPYYPL
TGDTRLELELRPTGEVEQYSVSATYELQREDRALVDTLKFVTQAEGVKQTEATMAFKYNR
QSMTLSSEVQIPDFD

ENSGT00590000083139_0_Linker_5_6 (1156, 4652)

VDLGTILRVNDESTEGRKSYRLTLDIQNKKITEVTLMGHLSCDTK
EEGKIKGVISIPRLQAEARSEILTHWSPAKLLLQMDSS--ATAYGSTVSKRVAWRYDEEK
IEFEWNTGTNVDTKKMTSNFPV----DLSEYPRSLHMYADRLLDHRVPQTDMTFRHMGSK
LIVAMNSWLQKASGSLPYTQTLQDHLNSLKELNLQNMGLPDFHIPENLFLKSDGRVKYTL
NKNSLKVEIPLPFGGKSSRDLKMLETVRTPALHFKSVDFHLPSREFQVPTFTIPKLYQLQ
VPLLGVLDLSTNVYSNLYNWSASYTGGNTST-D--HFSLRARYHIKADSVVDLLSYNVQG
SGEATYDHKNTFTLSCDGSLRHKF-LDSNIKFSHVEKLGNNPVSKGL---LIFDASSSWG
PQMSASVHLDSKKEQHLFVKEVKIDGQFRVSSFYAKGTYGLSCQRDPNTGRLNGESNLRF
NSSYLQGTNQITGRYEDGTLSLISTSDLQSGIIKNTASLKYENYELTLKSDTNGKYKNFA
TSNKMDMTFSKQNALLRSEYQADYESLRFFSLLSGSLNSHGLELNADILGTDKINSGAHK
ATLRIGQDGVSTSATTNLKYSPLVLENELNAELGLSGASMKLTTNGRFREHNAKFSLDGK
AALTELSLGSAYQAMILGVDSKNVFNFKISREGLKLSNDMMGSYAEMKFDHTNSLNIAGL
SLDFSSKLDNIYSSDKFYKQTFNLQLQPYSLVTTLNNNLKYNALDLTNNGKLRLEPLKLH
VAGNLKGAYQNNEIKHIYTISSAALS-ASYKADT---VAKVQGVEFSHRLNTDIAGLASA
IDISTNYNSDSLHFSNVFHSVMAPFTMTIDTYTNGNGKLALWGEHTGQLYSKFLLKAEPL
AFTFSHDYKGSTSHHLMSRKSISTSLEHKVSALLTPAEQTGTWKLKTQFNNNEYSQDLDA
YNTKDKIGVELSGRALADLTLLDYPIEVPLLLSEPVNVIDALEMRDAVEKPREFTIVAFV
KYDKNQEVRTINLPFFETLQEYFERNQRTIIVVLENMQRHLKRINIDQFVRKYRAALGKL
PQQANDYLNSFNWERQVSRAKEKLIALTKKYRITENDIQIALDDAKINFNEKLSQLQTYM
IQFDQYIKDNYDLHDLKIAI----------------HYHIRVNLVKTIHDLHVFIENIDF
NKIGSSTASWIQNVDTKYQIRIQIQEKLQHLKRHIQNIDIQHLAGKLKQHVEAIDVRVLL
DQLGTTISFERINDVLEHVKHFVINLIGDFEVAEKINAFRAKVHELIERYEVDQQIQVLM
DKLVELAHQYKLKETIQKLSNVLQQVKIKDYFEKLVGFIDDAVKQLDELSFKTFIEDVNK
FLDMLIKKLKSFDYHQFVDETNNKIRELTQRLNGEIQALELPQKAEAL-KLFLEETKATV
AVYLESLQNTKITLIIDWLQDALNSASLAHMKAKFRETLEDTRDRIYQMDIEKELQRYLS
LVGQVYSTLVTYISDWWTLAAKNLTDFAEQYSIQDWAKHVKALVEQGFTVPEIKTIFGTM
PAFEVSLQALQKATFQTPDFIVPLTDLRIPSVQINFKELKDIKIPSRFSTPEFTILNTFH
IPSFTIDFVEIKVKIIRTIDQMLNSELQWPIPEVYLRDLKVEDIPLARITLPDFHLPEIA
IPEFVIPNLNLNDFQVPDLHIPEFQLPHISHPIEVPTFGKLYSILKIQSPLFTLDANADI
GNGTT-SANEAGIAASITAKGESKLEVLNFDFQANAQLSNPKI--NPLALKEFVKFSSKY
LRTEHGSEMLFFGNAIEGKSNTVASLHTEKNILELSNGVILKINNQLTLDSNTKYFHKLN
IPKLDFSSQADLRNEIKTLLEAGHIAWTSSGKGSWKWACPRFSDEGTHESQISFTIEGPL
TSFGLSNKINSKHLRVNQNLVYESGSLNFSKLEIQSQVDSQHVGRSVLTAKGTALFGEGK
AEFTGRHDAHLNGKVIGTLKNSLFFSARPFEITTSTNNEGNLKVSFPLRLTGKIDFLNNY
ALFLSPSAQQASWQVSTRFNQYKYNQNFSAGNNQNIMEAHAGINGEGNLDFLSIPLTIPE
MP--LPYTTITTPP-LKDFSLWEKTGLKEFLKTTKQSFDLSVKAQYKKNKHRHSITNPLA
VLYEFTSQNIKSFDKHFEKARNNALDFVTKSYNDAKIKFDKYKAEKSHDELPRTFQIPGY
TVPV---VNVEVSPFTVEMLAFGYVIPKAISMPSFTILGSDIRVPSYTLILP-SLELPVL
QVPRNL-KLSLPDFKELCTISHIFVPAMGNITFDFSFKSSVISLNTNAEVFNQSDIVAHL
LSSSSSVIDALQYKLEGTTRLTRKRGLKLATALSLS-NKFVEGSHDSTVSLTKKNMEASV
ATTAKVQIPILRINFKQELNGNTKSKPTVSSSMEFKYDFNSSMLYSTAKGAVDHKLILES
L-----TSYFSIESSTKGDVKGSVLS-RDFSGTIASEANTYLNSKSTRSSVKLQGTSKID
DIWNLEVNENFAGEATLQRIYSLWEHSMKNHLKLEGLFFTNGEHTSKATLELSPWEMSAF
VQVQASQPNSFLDILHLGQEVALNTNTKNQKIRWKNEVRVHSGSFQNHVELSNDQEKAHL
DIAGSLEGHLRFLKNIILPVYGKSLWDFLKLDVTTSIGRRQHLRVSTAFVYTKNPNGYSF
SIPVKVLADEFI--IPGLKLNDLNSVLVMPTFHVPFTDLQVPSYKLDFREIKIYKKLRTS
SFALNLPALPEVKFPEVDVLTKYYQPEDSLIPFFEITVPESQLTVSQFTLPKSVSVGSAV
LDLNAVANKIADFELPTIITPEQTIEIPSIKFSVPAGIFIPSFRALTAHFEVDSPLYNAT
WSASLKNKADHVETVLDSTCSSTIQFLEYKLNVVGTHRIEDGMLASKTKGTFAHQDFSAE
YEEDGKYEGLREWERKVHLDIKSPAFTDLHLRYQKDKK-GVSTSAASPAIGTMGMDV---
--DFSKWNI---HYS-PQSSPNKKLTIFKTELR--FPESDEEIQIKVNWEEEAAS-GLLT
SLKDNMPKATGALYDYVNKYHWEHTGLTLREASSKLRRNLQSNAEWVYQGAIRQIDDID-
-LQFRKAASGTTGTYQEWKDKAQNLYQELL-TQEGQTSFQGLKDKVFDGLVRVTQEFHMK
VKHLIDSLIDFLNFPRFQFPGKPGTYTREELCTMFIREVGMVLSQVYLKVHNGSEILFSY
FQDLV----------ITLPFELRTHK---------LIDVISMYREWLK----VLSKEAQE
VFKDIQSLKT-TEVLRNLQDLL-QFIFQLIEDNIKQLKEMKFTYLINYIQDEINTIFNDY
IPYVFKLLKENLCLNLHKFN----EFIQNELQGASQELQQIHQYIMALREEYFDPSVVGW
TVKYYELEEKIVRLIKNLLVALKDFHSEYIVSASDFTSQLSSQVEQFLHRNIQEYLSILT
DTDGKGKEKIAELSTTAQEIIKSQAIAMKEI

PF12491 // ENSGT00590000083139_0_Domain_6 (4652, 4715)

ISDYHQQFRYKL-----------------
---LIDLSIQNYHTFLIYIMELLKKLQS-TTL--MNPYVKLAPGELTIIL----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------

----------------------------------------YRPARSCMKATET-------
----------LLTLVGLI--------------ST-FYVAEAALK

PF01347 // ENSGT00590000083139_0_Domain_0 (105, 674)

FKHLRKYVYNYEAATT
SGVSGTADSQSGTKFNCKVELEVPQSCNFILRVKQCTLREVYGVSSEGKALLKKSKNSED
FSNAMTKYEV-KVTVQDGKNVVLYPDKDEPLNVLNMKRGILSALLVDETQET-DYMVRNG
GQDTVYGKCTSEIKVTGRKGNTPTDVTVKRN----LKTCDRFTPIRDYVNPLAIIKGMNR
PLSTLISSSQVC-QYSLDPKRRHITEASCAETHLFLPFSYRDQYGINGKVTQTLKLEDVA
--KTNSRDFDPDTSLARGFALEATKTVSKN---EDAALENLQELQKLSTSEQNQQRASRF
YKLVTALRGLNNDSLGPLVPRLMQLSS--PIALQALTQCGTPECFGGILQVLRSGDISPV
ISDTVTFGLGLLPSPCTKRVRELLNMAQYQSSRASFYALSHAVSKFYE-EQQTVTDEL-R
DVADFMLSLIGNECTGNEDKTFQTLKAIGIMGSAMEATNPEIKSSLLKCARGQASSPDIQ
KAAIQAFRRMTMTDDVRGVLVQVFQDSNAPEQKRLAAYLMLMKNPSQSDLRKVVKVLLRD
DNKQVKNFVSSHI

ENSGT00590000083139_0_Linker_0_3 (674, 715)

RNILQMDAPEAEGLKTKLQEALKSSQPLNVDTDFTKLSQNY

PF09172 // ENSGT00590000083139_0_Domain_3 (715, 1025)

HFSRDV
TIPGLYDAAGADMVANIIFDSEGYMPKEAMLEATLNVFGK-SVDMFEIGVEGKGFEPTLD
SLFGNGGFFPDCTLKALYWADGKLPDKVTEILFKWYGVPRQSGQNQDLTKAILYNVEKLI
KEVRSNYAPEAKLYLEILGKELGYLQLNDFRTLGSMLLRTLHTTQELPAQIM-KAISKGA
ETDLFLHYIFMDNEFDLPTGSGLQLQVSFSGVIAPGTRAGMKFGGR-NIRAELSMKPAVA
VEFVTQMGIQIPEFSRHAVLMNTNLYHESGFEGRFSMKEGQLKFSIPAPKTPTKLFSIRN
QLNL

ENSGT00590000083139_0_Linker_3_5 (1025, 1041)

VFAS----KTEIMASI

PF06448 // ENSGT00590000083139_0_Domain_5 (1041, 1157)

LQNRVAQASCRPLFKGINSCTNL-EYSNASGKEGAPYFPL
TGEARFDLEIQPTGEVEEYSVIASYNLNREDEDMVDTFILSAQAEGSGPSDAKLITKYNR
NKVILTSDVQVPNYDVNFGAIMKLNDESTESKKSYAVMLDVHNQQVPEVTLTGKISYDGM
RDAQMEGMLSIPRLKVQLTSQASLQDFVQSLRIQMQSSAQ--ICSLSGSGSVAFTYDNEK
IDLEWSTETNTNVKKIISQLPDVEFSDVYNYPEMMKNYANEALDFKVAQTDMTMRHIASQ
SL--------------------VNKLTALKELDFPELGFPP--LPEILFLNSNGRIRGMF
SKDSIDITIPLPYGGRTTKQLM---SMRSPPVDMPSIGLKFPSKEFRIPSFTIPESYQLK
VPLFGSIDLSSNVKSNYYNWSASYSAGNTPSD---FPSYKADYEMKANAIWDILSYKIDG
AAAFSYNPDKFVLMSYTGSVLHNL-LEANINLKETYNFQSNPIVKET---IMFDVKSILG
VEGSFTSEAETASTNNLVTCDYNINGQFKLASLLTTSDYTLRVTFNTDNLQLNTESSFNV
DLSIIKLTNKMSAMILSERVTITSTTDVQDGALTNTMTLDYRNRQLTYKSDTNGNYYNLI
GLNKFEVTLSRQMAAIRSEYQADYKRNRFYTLLSGSLNSQGLELNADVSLNSQVNRAAHK
ATLKISQEGLSTSATTNVNFSPLTLENDLNAAIGLTGGMMKMTANGRYKEHNAKFTVDGK
AALTELSFGSVYQATVFGVGSKNVLSFKISKEGLKFSNNMMGSYDQMKLENSNDLVISGS
LAHFNSKLENALSTDKSYKHEFDLQLQPYTMTAMLNNEFLYGALQLSNMGQMELAVFSIK
VNGNMRGAFDKDNVKHSYAFSFSDLT-ANVKTDT---VANIQGTAHSHNVNMEIAGLSAS
FSSSTNSETKSTRFTNAIRSVVAPFTVTVDSHTNADGRLSIFGDHSGELYSKFILKAEPL
SFNLVHDFRGSTSHTLNSRNRHTTLLDYKVNALVTPSEQASSWKLKSQLNQNTHNQDFSL
YNNAEKIGIELSGQTLADLSILDGHIRTPFGVFNP---IDALSLRDSVTTPQEFSISGFV
KYDKNKDVHVINLPFIENIGSLFEKVRSILLTSLQALQNSLKSINIDQYVKKYKMTLNKI
PEQMNDYINNLDLERRINELKEQLIALTKDVKLSSEELYKAISS---TLQTARENLMSYL
SGIQQYIQENYDLERLTKAIETLLQQFIENVKSLEKQYNIREKAIDMVKGLQNQVEKINI
NELGESLAAWIKNVDDLYQIQANLRQILQKIQSLIQSINIEQIAINVREYFQSIDFSEYR
QRLMRALPINEINTAAEYIQDYIVILLMEYEVTEKFNAVVDKLQDVVSEYEIDKKVQTLL
ENFIQLLNQQKVKETIKKVTDMLTNIDIKMYYRRLMAFIQDSVKKVKEYDFKKLVDDINE
FLNVCVMKLKSFNYEKFVDDVNNWIQEVRQTINDNMKALELPQKAQAL-KQYMNDVSVMA
TEYVQQVRDTRLSAVMQWYEDIMSSAILNELRTRILQYLEDVRDTINSMNIKQEIQIYLQ
KLSQAYQRIVTYVTNEWKNMSEKIEMFAKEHSIEEWAERFKLFIEEGFPVPEMNLGLMTI
PPFEVSLRALKDATFKTPSFTILLTDLQVPSVEINLKKLKEIEIPSRFVIPEFTILSSIK
VPSYVIDLHELKLRIVRIIDQVLHSDFQWPSPETYLKDLKMSDMGFPAITFPEMNMPSMQ
IPEIKIPKLNLNNFQFADIQIPEFRLPQIPHSVSVPTFGKLSSSFIVKSPFLTLSTAAEM
KNGTV-SEKNPEFIASLSATSTSMIEALAFNLVADARISAPML--EQLILKETVAASNKY
FKLDHNSEATFAGSYIQTKVQTVASLKTEKNEASLDNAILVRLQGRITAESNTKYSHKLN
IPEFDISSQLELQNDVESFLEAGRILLISSGKGNWKWACPLISDEGTHQSNLKFNIMGSL
VELSGSNKITDKYLKLDQAFKYDSALLSYVNVDITSKAESPYVGNSIISVKGSGQLSDMT
LGLTATHNAELSGRATGTIQNALTFAAKPFDINLSTTNNGNLKVGFPLKLTGKIEFLNNY
NFILNTNVQQISWQVNGRFNQYKVSHTISVGNNEDSVVAIVGMNGEANLDFLTIPISIPE
MN--VPYTSMKTPE-VKDFSLWEQAGLKKLLTTTKQNVDLNVKLQYKKNMDVHSIQLPLD
SLYDSINSNMKVLTKNFEKGRDNTLRMLTDSYNEAKAKFDKYKVENSAGKAPRTIRVPGY
TIPL---LNIEVSPFSAELPAFGYVIPKEISTPSFSLPVMGFSIPTYTVVLP-SLELPVL
HVPNTLRKLTLPKLKLPSGPHTISIPAMGNLTYDFSFKSNVISLTTSAGLYNQSDLSARI
SVASTSIINALQFTIDGTTGLTRKRGLKLATALAV-KHVFVDGKHESSMSLGKRNIEASV
VTNAKVSLPIIQLTFKQELNGNTKTKPNLSSKMSLSYSENDAIM--VSKGMIDHTLTIEG
L-----TSYFSMETKTNGDITGTLLGQQGFSGKFTNEANTYLNSNGLRSSMKLVGSSKAD
SVGNLDVAENLAVEATTSRIYAVWEHNGENYLRVTPLFTTKGLQNCKATFELALWSLLAN
LQVKIEQPNSMLENLALNQEILLSANEEKQEIGLNGDGTFHTIILAHNVKLSNDKTDARF
QIDGSLQGHASMLKYVILPVYEKSLWEILKFDVTTSEDKQQYLNVSTSVTYTKNKEGFWF
PIPINKVADGN---------------------------LNVPSTKLDLNNIKISEIKSTL
PFDINLPSLPQIKFPKVDITTKYITVEEYKIPFFEVTIPQHQITLARYTLPKSFY----N
IDFNSLVNKIADIDLPTIEIPEQNIEIPPIKMNLPAGIFIPAFGALAGTAQLSSPIYNLT
WTNKMANNADGFVASIDASSSSTLRFLEYDLDAVASASTAPT-NGLVLQGTFAHTDLSIN
WKDDINFNGLRIPGHNIDIDIKSPTFTDVQIRSQQENN-KITSSVSSSSAGTLGLVLEKE
S-SALKGKL---FSR-SLSTPGKDTLIMKGEV---SLKNPERIQYKINWREEAAM-DVLN
GLKERLPKISNSIHNCVNKYHKEHFGMEISEDKI----------ASTYRSTANEINNIE-
-YQLQSTARGASDKYNEIVNSAQKWYQDPK-DM----SMFLNDGEYKDKAIELVRAYQNK
MKDLIDAAIKFVKNTRFQLPGQSRKYTGEELFNLGMKNVASNIDAFFKAMQQIYDACVQY
INRTE----------LKIPGTEVTIK-------------GKEITDACKSFSANLERMTKK
AIQDLQGVSL-ESALNQLKSFI-QVITQKTVDMIKALQTKNIEDVKLQFQQMYSDAMKSD
YARELQNLVEELKKATSQLQ----KYAQTGHEELSEKLKQLQVYAKALREEYLDPNIVGW
SVKYYEIEEKVIQLLQKIVDSLKDLSSQYGINTA----EITEQTKDFVKKYYQHANDLLT
NANGQGKELIRRASIDLEDRVTKWSATARQLSQNANKILNEKLQATSNLFVNSYEKLIAE
ASRLIDIIIQNYNSFIEYVNQLLQSIQ---------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------

-----------------------------------------------MGPSGP-------
------ALL-ALLLLM--ITAGAGAEDEVLENVN-PSCSKGTTR

PF01347 // ENSGT00590000083139_0_Domain_0 (105, 674)

FKHLRKYVYNYEAESS
SGAPASTDSRSVTKINCKVELEVPQLCSFILKTSQCTLKEVYGFSPEGQALLKKAKNSEE
FSAAMAKFEL-RLATPEGKQVLLYPDKEEPKHILNIKRGIISALLVPPETEEDKQVL---
FLDTVYGNCSSDVTVKTRKGNVATEISIERN----LEKCDHFKPVSTGVSPLALIKGLTQ
PLSTQISSNQSC-QYTLDPKRKHVSEAICQEQHLFLPFSHKDKYGMMALVTQTLKLEDTP
--KINSRFFDEG-TEEVGLTFETTKSTSPPKQ-AEAIVKTLQELQKLHVSEQNAQRANLF
SRLVTELRGLNNEAVASLLPKLVEVSS--PITLQALIQCGQPQCYTHILQWLRNEKANPL
LIDVVTYLVALIPGPSAQRLQEIFNTAKEQQSRATFYALSHVIHNYHK-THPKATQEL-L
DIADYLLEQIQDDCTGNEDHTYLSLRVIGNIGGTLQKLTPRLTSSVLKCIKSTAPSLLIQ
KAAIQALRKMENKDEVREVLLQTFLDEAAPGDKRLAAYLMLMRDPSQSDVSKVTQLLPGE
QNEQVKNYVASHI

ENSGT00590000083139_0_Linker_0_3 (674, 709)

ANILNSDELYVQSLKELVKEALKDSQ-LPTVMDFR

PF09172 // ENSGT00590000083139_0_Domain_3 (709, 1025)

KFSRNYHFSKSV
SLPSLT-PFSTKLEGNLIFDPDNYLPIESMLKTTLTVFGFESADLFELGLEGKGFEPTLE
AFFGKQGFFPDSVNKALYWVDGKVPDRVSEVLEDHFGYTKDDKREQDMVKGIMGNVEKLI
KDLKSKDFPEARAYLRILGEELGFVKLDDLQLLGRLLLNGVHTLKGIPHMVA-EALKKGS
KNDLFLHYIFMDNAFELPTGLGLPLQVSSSGVLAPGIQAGVKLEVKDKMQMELVTKPSVS
VEFVTNMGIVIPDFARNGVQMNTNFFHETGLEARVGLNLGHLKFSIPAPKRPVKLFSVSN
TMHL

ENSGT00590000083139_0_Linker_3_5 (1025, 1041)

VSTT----KTELIPLL

PF06448 // ENSGT00590000083139_0_Domain_5 (1041, 1157)

KENRNSWSTCKPFFTGLNYCTTG-TYS-----NTSSYSPL
TGDTRYELKLRPTGEVEQYSASATYNLQKEGKARVDTLEFVAQAEGVKQTEATMTIKYNR
QTMTLTSETQIPDFGIDLGTVLRVSDESAEEKTSYKLTLDIQNMKITEVAFTGLISYDKK
EEAKIKGVLSVPRLQAEARSETLAQWSPTKLLLQMDSS--ATAYGSTISKKLAWRYDGEK
IEFEWNAGTDVDTKKAASSFPV----DLSDYPKSLHMYTNRLLDHRVPKTDMTFRHMGSK
LMVATNTWFQKAFASLPYTQNLQEYL---KQLNLQKMALPEFHIPENLFLKSDGRVKYTF
NKNSVKIEIPLPLGGKSSKDLKMLETVRTPVISLPFLGFYQPSQEFQLPSFTIPKLYELR
VPHLGVLDLSTNIYSNLYNWSASYTGGNTST-D--HFSLQARYHMKADSAVDLLSYSVQG
SGETTYDHRNTFTLSCGGSLHHKL-LDSNVKFSHVEKMGNNPASKGL---LTFDASSPWG
PQMSASVHLDSKQKEQLYIKEVKIDGQFRVSSFYANGAYGLSYQKDPASGQRTGESNLRF
NSTYLQGTNQIIGRYEDGTFSLTSSSDLQDGIIKNTASLKYENYELTVKSDTNGQYQDFT
TSNKVELAFSTQKASLSSVYQADYRSLRFFTQLSGSMNSHGLELNAEILGTDKINTGAHK
ATLRIARDGMSTSTTTNLKYSPLMLENELNAALGLSGASVKLTTNGRFREHNAKFSLDGK
AALTEVSLGSAYQAMILGVDSKNIFNFKINQEGLKLSNDMMGSYAEMKLHHTHSLNMAGL
SLDFSSKLDNIYSSDKSYKQTFNLQLQPYSLVTTLNNDLEFNDLDLTNHAKLRLEPLKLN
VGGNIKGAYRNDEIKHIYTLSYADLS-ASYKADT---VAKVQNTEFSHRLSTNIAGLAST
TDISTSYNSDSLHFSNVFHSVMAPFTVTVDVHTNSNGKLVLWGEHTGQLYSKFLLKAEPL
ALTFSHDYKGSTSHHLMSKRSVSTALDNKVGALLTPAEQTATWKLKTQVNKNEYTQEFDA
YNTKDKVGMDLTGRALADLTMLDSPIEVPFLVRDPVNVIDALEIKDTIDQPQEFTMVASV
KYDKNQDVHTINLPFFNLLPEHFEKSRIIIITALEAIQRELKHIDIDQFVTKYRAALDKF
SEKVNVQLNEVNWETQVSRAKEKLTAFIKNYGITENDLKMALDNAQINFNETLSQLQTYV
IQVDQYIKDNYDV---KAAIAKIIDQIIKNLNILDKRYRIRVTLVKVIHNLHLFIEKIDF
NKVGSNTVSWIQNVTDRYQIIIQVQEKLQQLKTQIQNFDMQHLAEKLKQQIEAIDVRVLL
DQLRAAISFQKIKQMIEHVKNYVGKLIEDFEVTKKINAFRTMVHKLINRYKIEQHIQILM
DKSVQLAQKYKLKETLQKLGNVLKQVGIKDHFEKLVGFIDDAVTQLKAWSFKNFIKEVNR
FLDRI-NKLRSFDYHWFIDETNNKIREVTRSINEEIQALDLPQKAKAL-KLFVEDIKAAV
SVHLENLNSTKITLFIDWLQEALRSPSLNHMKAKFQETLEDIRDQMYRMDLQQKVQQFLP
QVGQIYKTIVSCISNLWNLAVKNLNDFAEQYSMQDWAENLKALVEQGFIVPEIQTIFVTI
PSFEVSLRALQEATYQTPEFIVPLTDLKVPSVQINFKKLEDIKVPSRFSTPEFTVLNTFH
IPSFTIDLVEIKAKIIRIIDQMLNSELQWPVPEVYLKDLMDTDTILARITLPDFHVSEIT
IPEFVIPKLDLKAFQIPDLHIPEFQLPKISQTIEVPTFGKLHSVLKIQSPLFTLDANADI
HNVTT-SVNEAGITASITAKGHSKFEVLKFDLQANAQLSYPKM--KPLVLKESVSFSSKY
LNTEHKSEVLFFENTFEGKSNTVAGLQTEKNTMELSNGVLIKINNQITLDSNTKYFHKLN
IPKLDFSSQADLHDEIKTLWDSEKIAWTSSGRASWKVACPKFSDEGTRESQISFTMRGLL
TSFEFSNKINSKHLRVNQTLAYESGFLNYYQLEIQSQVESQHVGHSILTAKGTAQLSERK
VEVTGNHDAQLNGKVSGNLKNSLFFSAIPFEITASTNNEGNLKVIFPLKLTGKIDFLNNY
ALFLSPNAQQASWQAGARFNQYKYNQNFSAGNNENSTDAHIGISGEANLDFLNSPLTIPE
MT--LPYTGFKIPQ-VKDFSLWEKTGLKEFLKTTKQSFDLSVKAQYKKNKDKHSIPIPLD
VFYVFINQNINSFNRHFEKVRGKALNLFTKSYNEAKIKLNKYMVEKSLNKEPMTLQIPGY
TIPV---VNTELSPFTAKMWTFGF----EIRTPNLTTPDSGFYVPSYAIVLP-SLELPAL
NIPRNFLKFSLPELKVLSIPN-ILIPAMGNITYDFSFKSSVITLNTNVGLYNQSDIVAHF
LSSSSSVIDALQYKLEGSSSLTRKRGLKLATALSLS-NKYVEGNHDSTISLTKKTMEASV
TTTANVQIPILRMNFKQELNGNTKSKPTVSSSIELKYDFNSTKLYSTATGTVNHKFSLES
L-----TSYFSIELSNKGDIKGSVLS-REYSGMIASEVSTYLNSKGTRSSVKLQGASKVE
RLWNLEVKESFAGEASLQRIYATWEHNTRNHFQLL-YPLTSGEHSGKATLELSPWKMSAL
AQVHASQLSSFLDLNHLGQEMSLNVNPENQKASWKGEVQVHSLSLQNGVQLSNDQDETRL
DIAGSLEGYLKFLDSIALPVYDKTLWEFFKLDVTTSKDRKQYFHASTALVYTKNPKGYTF
SVPVQELADKFV--IPGLRLNNLNSVLLTPAFQVPFTDLQVPSYTLDFSEIKIYKKLSTS
PFSLNVPALPKVKFPEVDVLTKYSGPEDSSVPFFEITVPGFQLTMPQFTYPNSISVGATV
LDLNEMAGKIADFRLPNITVPDQTIEIPSIKFSIPSGIYIPSFGALTARFGVASPLYNAT
WNAGLKNKEDHVETYLNSTCSSIIQFLEYDLKGIGTYKIEDGMFVYKAKGTFTHRDISVE
YKEDAKLQEYPDWKVEVLLDITSPVFTDVHIHCHAHEN-V-FYSAASPAIGTVVLDLGSD
N-TTITYNF---YYR-PQSSPDKNLSIFKIEYRHPYAESNEKFQIKVNWEKEAVS-QLLS
SLKDNVPKATGALYNYVNKCHQEYTGLNLREASLKLRRGLQNKAEETCQGALILIDKVNK
TLEFKRVARGAARTYQLWNDKVQILYQDLL-DQEGHIDLQRLQNKVLNILINIIREYETT
VRHVIAWLTEYLQRTRLPLPGRASTNTTDELSTLVMRGVGKILLQVHSNIHNGLEILFSY
VQGLMEKSELIKDLKIKFPFDSRSLK---------LTNVTLEYGKQLN----SFSQMVQR
VLNALKSNKT-TVILGDLQRYL-EGVFEYIREEINHLKMKKLTVIIKNIKHEIKVIFDSC
IQYVSQFLKENLGLDFDELD----ELVQNKFQEASQELEQLHQYIKALRKEYLDSSVVSW
TLKYYEYEEKVINLVKKLVHALTYFYSKYTVNAAGMASQLSSEAEQLVQQAIQNYLSILV
DADGKGQEKIVELFTSAEEIIKNRTAAMKEIISDYHQQFKDILQNFSDRLFDYYEKFIAE
SQILIDLSIQTYHMFLIYITGLLKELQS-TTVYDLSRYLKIAPGELTITF----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------

------------------------------------------------------------
MGPPRPALPAL--LLLLLLLAGARAEEEVLENVT-PICSRDATR

PF01347 // ENSGT00590000083139_0_Domain_0 (105, 673)

FRHLRKYVYSYEAESS
SGVPGTADSRSVTRINCKAELEVPQPCSFILKTSQCTLKEVYGFNPEGKALLKKTKNSEE
FALAMSRYEL-KLAIPEGKQVFLYPEKDEPTHILNIKRGIISALLVPSETEEAKQVL---
FLDTVYGNCSTDFTVKTRKGNVATEISTERD----LGRCDHFKPISTGTSPLALIKGITR
PLSTLISSSQSC-QYTLDAKRKHVAEAICKEQHLFLPFSYKNKYGMMTQVTQTLKLEDMP
--KINSRFFGEG-TNKMGLAFESTKSTSPPKQ-AEAVLKTLQELKKLTVSEQNSQRANLF
NMLVTELRGLSDEAVTSLLPQLIEVSS--PITLQALVQCGQPQCYTHILQWLSSVHANPL
LIDVVTYLVALIPEPSAQQLREIFNTARAQRSRATLYALSHVVNNYHE-TNPTETQEL-L
DVANYLMEQIQDDCTGDEDYTYLILRVIGNMGQTMEQITPELKSSILKCVQSTKPSLMIQ
KAAIQALRKMKLKDKDQEVLLQTFLDGASPGDKRLAAYLMLMRDPSQADINKIVQLLLRE
QNEQVKNFVASH

ENSGT00590000083139_0_Linker_0_3 (673, 709)

IANILNSEELYIQDLKKLVKEALEESQ-LPTVMDFR

PF09172 // ENSGT00590000083139_0_Domain_3 (709, 1017)

KFSRNYQLSKSV
SLPSLD-PVSAKIEGNLIFDPNNYLPKESMLKATLTVFGFAPADLFEIGLEGKGFEPTLE
ALFGKQGFFPDSVNKALYWVKGQVPDGVSKVLVDHFGYTKDDKREQDMVKGMMLSVEKLI
NDLKAKEVPEARAYLRILGEELGFARLHDLQLLGKLLLMGARTLQGIPQVIG-EIIREGS
KNDFFLHYIFADFAFELPTGAGLQFQMSSSGVITPGAKAGVKLEVA-NMEAELVAKPSVS
VEFVTNMGIIIPDFARSGVQMHTNIFHESGLEARVALKAGQLKFIIPSPKRPVKLF

ENSGT00590000083139_0_Linker_3_5 (1017, 1044)

SGGN
TLYLVSTT----KTEVIPPLIEN

PF06448 // ENSGT00590000083139_0_Domain_5 (1044, 1156)

RQSWSTCKPFFTGLNYCTSG-AYSNASSTDSASYYPL
TGNTRLELELRPTGEIEQYSVSATYELQREDRALVDTLKFVTQAEGVKQTEATMTFRYNR
QSMTLSSEVQIPDFD

ENSGT00590000083139_0_Linker_5_6 (1156, 4658)

VDLGTILRVHDESTEGKKSYRLTLDIQDKKITEAALMGHLSYDTK
EEGKVRGVIFIPCL-------------PAKLLLQMDSS--ATAYGSTVSKRLAWHYDEEK
IEFEWNTGTNVDTKKMASNFPD-----ISDFLWSLAFNVIDLLDTRIPPTDMSLWYMGSK
LIVTTQSWLQQASESLPYAQTLQDHLSGLKELNLQNMELPDFHIPENLFLKSDGRVKYTL
NKNSLKIEIPLPFGGKSSRDLKMLETIRTPALQFKSVGFHLPSQEFQVPTFTIPELYQLQ
VPLLGVLDLSTNVYSNLYNWSASYTGGNTST-D--HFSLRASYHMKADSVVDLLSYNVQG
SGETTYDHKNTLTLSCDGSLRHKF-LNSNIKFSHVEKVGNNPVSKGL---LTFDASSAWG
PQMSASVHLDSKKKQHLFVKEVKIDGQFRVSSFYAKGTYGLSCQRDPNTGRLNGESNLRF
NSTYLQGTNQITGRYEDGTLSLTSTSDLQSGIIKNTASLKYENYELTLKSDTNGKYKNFA
TSNKMDMTFSKQNALLRSEYQANYESLRFFSLLSGSLNSHGLELNADILGTDKINSGAHK
ATLRIAQDGVSTSAMTSLKYSPLVLENELNAELGLSGASMKLTTNGRFRDHNAKFSLDGK
AALTELSLGSAYQAMILGVDSKNLFNFKISQEGLKISNDMMGSYNEMKLDHTNSLNIAGL
SLDFSSKLDNIYSSDKFYKQTFNLQLQPYSLVTTINNDLKYNALDLTNNGKLRLEPLKLN
VAGNLKGAYGNNEIKHIYTIAYAALS-ASYKADT---VAKVQGVEFSHRLSTDIAGLASA
VDISTNYNSDSLHFSNVFHSVMAPFTMTIDAHTNGNGKLSLWGEHTGQLYSKFLLKAEPL
AFTFSHDYKGSTSHHLMSRKSISTTLEHKASALLTPAEQMGTWKLNTQFNNNEYSQDLEA
YNTKDKIGVELSGRALADLTPLDSPIKVPFLLSEPVNVIDALEMKDATEMPQEFTIVAFI
KYDKIQDVHAISLPFSETLQEYFERNLQTVIIILDNMQRGLKHININQFVRKYKAALGKL
PQQVDDYLNSFNWERQVSYAKEKLTALTEKYRITENDIQIALDDAKINFNEKLSQLQTYV
IQFDQYIKDNYDLHDLKIAIANIIDRIIEKLRSLDEDYHIRVNLVKTIHDLHLLIENIDF
NKTGSSTASWIQNVDTKYQIRIQIQEKLQQIKRHIQNIDMQHLAGKLKQYAEATDVRVLL
DQLGTTISFERINDILEYVKYFVIHLIGDFEVAEKINAFRTKVHELIERYEIDQKIQVLM
DKSVELAHQFKLKETTQKLSNVLQQVKIKDYFEKLIGLIDDAVNLLDELSFKTFIEDVNK
FLDMLIKKLRSFDYHQFVNETNNKIHEVTQRLNGEIQALELPQKAKAL-KLFLEDTKATV
EVYLESLQDTKITLFIDWLQDALSSASFAHMRAKFRETLEDTRDRIYQMDIQQELQRYLS
LVGQVYSTLVTYISDWWTLAAKNLTDFSEQYSIQDWAKRVKALVERGFTVPEIKTILGTM
PAFEVSLQAVQKATFQTPDFIVPLTDLRIPSVQINFKELKDIKIPSRFSTPEFTLLNTFH
IPSFTIDFVEIKVKIIRTIDQMLNSELQWPVPELYLRDLKVEDIPLARITLPDFHLPEIA
IPEFVIPNLNLSDFQVPDLHIPEFQLPHISHTIEVPTFGKLYGILKIQSPLFTLDANADI
QNETT-SVNEAGIAASITAKGESRLEVLSFDFQVKAQLSAPKI--NPLALKESVKFSSKY
LRTEHDSEMLFFGNAIEGKSNTVASLHTEKNTLELSNGVIVKINNQLTLDSNTKYFHNLN
IPKLDFSSQADLRNEIKTLLEAGHVAWTSSGKGTWKWACPQFSDEGTHESQISFIMEGPL
TSFELSNKINSKHLTVNQNLVYESGLLNFSKLEIQSQVESQHVGRSVLTVKGTALFGEGK
AELTGRHDAHLNGNVIGTLKNSLFFSAQPFEITVSTNNEGNLKVSFPLRATGKIDFLNNY
ALFLSPGAQQAGWQVSARFNQYKYNQNFSAENNENIMEAHVGINGEANLGFLNISLTIPE
ML--LPYTTITTTP-LKNFSLWEETGLKELLKTTKQSFDLSVKAQYKKNKHKHSITNPLA
VLYEFISQNIKSFDGHFEKARNNALDFVTKSYKEAKIKFDKYKAEKSHNELPSTFQIPGY
TVPV---VNVEVSPFTVEMSAFGYVIPKAVSMPSFTISGSDIRVPSYTLTLP-SLELPVL
HVARHL-KLSLPDFKELCTISHIFIPAMGNITYDFSFKSSVITLNTNAELFNQSDIVAHL
LSSSSSVIDALQYKVEGTTRLTRKRGLKLATALSLS-NKFVEGSHNSTVSLTKKNMEASV
VTTAKVQIPILRMNFKQELNGHTKSKPTVSSSMEFKYDFNSPMLYSTTKGAVDHKLSLES
H-----TSYFSIESSTKGDVKGSVLS-REYSGTVASEASTYLNSKSTRSSVKLQGTSKID
DIWNLEVKENFAGEATLQRIYSLWEHSTKNHLQLEGLFFTNGEYTSKATLELSPWEMSAL
VQVHASQPNSFLDIPYLGQEVALNANTKNQKIRWKSEARVHSGSLHSHVELSNDQEEAHL
DIAGSLEGHLRFLKNIILPVYDKSLWDFLKLDVTSSMGRRQQLRVSTALVYTKNPNGYSF
SIPIKVLADEFI--IPGLKLNDLNSVLVMPEFYVPFTDLQVPSYKLDFREIKMYKKLRTS
SFALSLPTLPKVKFPEVDVLTKYSQPEDSLIPFFEITVPESQLTVSEFTLPKSVSVGGAV
LNLNEVAKKIADFELPTIIMPEQTIEIPSIQFSVPAGIFIPSFGALTARFGVASPLYNAT
WNASLKNKADHLETVLDSTCSSTIQFLEYDLNVVETLKITDGRLTCKTKGTFAHRDFSAE
YEEDGKYEGLKEWEGKARLDIKSPAFTDLHLHYQEDEK-GLSISAASPAIGIMGMDMDED
D-DFFKWNF---YYR-PQSSPDKKLTIFKTELR--YQESDEELQIKVNWEQEAAS-GLLT
SLKDNVPKATQALYDYVNKYHWEHTGLTLREASSKLRRNLQNKAEWVYQGATRKIDDMD-
-MWFQKAASGTTGNYQKWMGKAQNLYQELL-TQEAQVSLQEFKDKVFDSLIRVTQEFHMK
VKHLIDSLIDFLTFPRFQVPGKPGTYTRDELCSMVIREVGMVLSQVYSKVHNGSEILFSY
FQDLV----------IKIPFELRSQK---------LLDIILMYRELLK----DLSKEAQN
VFENMQSLKT-TEVLHHLQQLL-QFIFQLIEEEFKELKETKLSQLTNHIRDDINTIFNDY
IPFYFKLLKETLCRNLYTFN----EFIQNNLQEASQELQQIHQYIMALREEYFDPSVVGW
TVKYYELEEKIISLIKNLLVTLRDFHSEYTVSASGFASQLSTQVEQFLHRNIQEYLSILT
DADGKGKEKIEELSCTAQEIIKSWAIAMKAIISDYHQ

PF12491 // ENSGT00590000083139_0_Domain_6 (4658, 4716)

QFRYKLQDFSDQLSDYDEKFIAE
SKRLIDLSIQNYHTFLRYITELLKKLQS-ITV--MNPFMKLAPGELTIIL----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------

------------------------------------------------------------
------------------------AEAEVQENVS-PSCSKDTTR

PF01347 // ENSGT00590000083139_0_Domain_0 (105, 673)

FKHLRKYTYIYEAESS
SGVPGTADSRSTTKITCKVELDVPQPCSFILKTSHCTLKEGYGFNPRGKTLLKKTKNSEE
FGAAMSKYDL-RLAVPEGKQVLLYPEKDEPKHILNIKRGIISTLLVPPETEEATQVL---
FLDTVYGNCSSNFTVKTRKGNVATEISIERN----LDKCDHFKPMSTGVSPLALIKGMIR
PLSTLIGSSQSC-QYTLESKRKHVSEAICKEQHLFLPFSYKNKYGMMVQVTQTLKFEDTS
--KINSRFFEEG-VEEVSLAFESTKSTSPPKQ-AEAIVETFQELQKLHVSEQNAQRANLF
NKLVTELRSLNHVAIASILPKLIQVSS--PITLQALIQCGQPHCYTHILQWLKSEKANPL
LIDVVTYLMALIPEPSAQRLREIFNTTKEQQSRATFYALSHVVNNYHK-TNPTVTQDL-L
DIADYLLEQIRNDCTGNEDHTYLILRVIGNTGKTMEQLTPRLTSSVLKCIKSTEPSLLIQ
KAAIQALRKIELKDEVREVLLQTFLDDASPGDKRLAAYLMLMRSPSQSDINKITQLLPRE
QNEQVKNFVASH

ENSGT00590000083139_0_Linker_0_3 (673, 709)

IANILNSEELHIQDLKKSVEEALKTSQ-LPTVMDFR

PF09172 // ENSGT00590000083139_0_Domain_3 (709, 1025)

KFSRNYHLSKAI
SLPSLD-PVSAKIEGNLIFDPNNYLPTESMLKMTLSIFGFAPVDLFEIGLEGRGFEPTLE
ALFGKQGFFPDSVSKALYWVDGRVPDHVSKVLVDHLGYSKDDKHEQDMVNGIMLNAEKLI
KDLQSKEFPEARAYLQILGEELGFVRLHDLQLLGRLFLNSVRTLQGIPQMIG-DIIRTGS
KNDLFLHYIFMDNAFELPTGLGLQLQVSSSGVITPGIKAGVKLEVA-NMQAELVAKPSVS
VEFVTNMGIIIPDFARSGVQMNTNFFHETGLEARVALKAGQLQFIIPSPKRPLRLLSGSN
TLHL

ENSGT00590000083139_0_Linker_3_5 (1025, 1043)

VSTT----KVEVIPPLTG

PF06448 // ENSGT00590000083139_0_Domain_5 (1043, 1156)

NRQSWSVCKPFFTGLNYCTTG-AYSNANSTDSVSYYPL
TGDARFELELRPTGEVEQYSASATYKLQKEGGALVDTLKFVTQAEGKKQNEATLMFRYNR
QSMTLSSEIQIPNFD

ENSGT00590000083139_0_Linker_5_6 (1156, 4658)

VDLGTILRVSDESAQERKSYKLTLDFQNKKITEVTLTGHVSCDRR
EEGKIKGVISIPRLQAEARSEILTQWSPTGLLLQMDSS--ATAYGSTISQKVAWRYDEEK
IEFEWNTGTNVDTKKAASNFPV----DLSDYPKSLHMYASSLLDHRVPQTDVTFRHMGSK
LIVATNTWLQEASSSLPYAQNLQDRLSGLKESYLQKMRLPDFHIPENLFLKSDGRVKYTF
NKNSVKIEIPLPFGGKSSKDLKILDMIRKIDLVFKSGGLYLPAQESQVPPFTIPKAYQLQ
VPLLGVLDLSTNIYSNLYNWSASYTGGNTST-D--HLSLQAQYHMKADSVVDLFSYRVQG
SGETTYDRRNTLTLSCDGSLHHKF-LDSNIKFSYVEKMRNNPASKGL---LTFDASSAWG
PQISASVHLDSKKKQHFYVKEVKIDGQFRVSSFYAKGAYGLSYQRDPNTGQLNGESNLRF
NSSYVQGTNQITGRYEDGTFSLTSTSDLQ-GIVKNTASLRYENYELTLKSDTNGKYENFA
TSNKMDLTFSKQNALLRSEYQADYKSLRFFALLSGSLNSHGLELNADVLGTDKINSGAHK
ATLRIAQDGMSTSATTNLKYSPLVLENELNAALGLSGASMKLTTNGRFRQHSAKFSLDGK
AALSEISLGSAYQAMILGVDSKNIFNFKINQEGLKLSNDMMGSYAEMKLDYTNHLNIAGL
SLDFSSKLDNIYDSDKFYKQNFNLQLQPYSLVTTLNNNLKFSALDLTNNGKLRLEPLKLN
VGGNIKGAYQNNEMKHIYTISYADLS-ASYKADT---VAKVQDTEFSHRLSTDIAGLASA
IDIRTNYNSDSLHFSNVFHSIMAPFTVTIDSHTNGNGKLVLWGEHAGQLYSKFLLKAEPL
AFTFSHDYKGSMNHNLVSERSISTALDHKVSALLTPAEQTGTWKLKTKLNKNEYSQDFNA
YNTKDKVGVELSGRALADLTMLDSPITVPFSLSEPINLIDALEMRDDVDQPQEFTIVASI
KYDKNQDVHTINLPFSKILLEYFDKNRIVIVTVLETIQKELKRINIDQFLRKYRAALDRL
PQQVNDYLNAFSWERQVSSAKEKLTAFTKYYKITENDIQIALDKAKINLNEKLSQLQTYV
IQFDQYIKDNYDLHDFKTAIAGIIDQIIEKLKILDEHYHIRVNLAKTIHNLYLFIEKIDF
NKIGSSTASWIQNVDTKYQIRIQIQEKLEQLKTQIQNIDIQLLAENLKQQVEAIDIRVLL
DQLRTTIPFQRIMEIIENVKCCIITLTEDFELTEKIDAFGATIYKLIKMYEIDQHIQVLM
DNSVQLAHQYKLKETVQKLSNVLQQVEIKDHFERLAEFVDDAVKQLNALSFKKFIEEVNR
FLDMLVKKLRSFDYHKFVNETNNKIHEVTQRINGEIQALELPQKAKALKKLFVEHIQAMT
SDHLENINNTKITIFLDYLQEALSSASSGYIKAKFQDILEDVRDRMYQMDIQQEIQRYLS
LVGQVYSTLVTYISDWWSLAAKNLTDFAEQYSMQAWAENLKALVEQGFTVPDIHTTFGTM
PAFEVSLHALQEATFQTPDFIVPLTDLRIPSVQINFKKLKDIKIPSRFSTPEFTVLHTFH
VPSFTIDLREIKAKIIRTIDQMLNSELQWPVPEVYLRDLLGVDTILAGLTLPDFHLPEIT
VPEFIIPNLDLKDVQVSDLHIPEFQLPHISHTIEVPTFGKLYSILKIQSPLFTLDANADV
QNVTT-LVNKAEIAASITAKGESKLEVLNFDFQANAQLLAPKI--NPLVLKESMRFSSKY
LKTEHESEVLFSRNAIEGKSNTVANLHTEKNTVELSSGVLVTVNNQLTLDSNTKYFHKLN
IPELDFSSQADLHNEIKTLLEAGHIAWTSSGTGSWKWACPKSSDEGTHESQISFTVEGPN
TSFGLSNKINSKHLRVTQNLVYNSGFFNFSKFEIQSQVESQHVGRSVLSAKGTALLGEGK
AELSGHHDAHLNGKVIGTLKNSLFFSAQPFEITATTNNEGNLKVSFPLILVGKIDFLNNY
ALFLSPHAQQASWQTSARFNQYKYHQNFSAGNNENSIEAHIGINGEANLDFLNSPLTIPE
MT--VPYTTLTTPQ-VKDFSLWEKTGLKNFLKTTKQSFDLGVKAQYKKNKDKYSIQNPLD
VFYVFI----NSFNRHFEKARDESLDFFTRSYNEANIKFDKDKVENSLNKQPRTFQIPGY
TIPV---INIEASPFTVEMSTCSYVIPKEISTPNFTIPGSGFYVPSYKLVLP-LLELPAL
HVPRNLLELSLPVFKVLSIPHNILIPAMGNITYDFAFKSSVITLNTNFGLYNQSDIVAHF
LTSSSSVIDALQYKFEGTSSLTKKRGLKLATALSLS-NKFVEGKHESAISLIKKTMEASV
TTIAKVQIPILRMNFKQELSGNTKSKPTVSSSIELKYDLNSPTLYSTAIGAVDHKLKLES
L-----TSYFSIESSTKGNIKGLVLS-REYSGTIASEANTYLNSEGTRSSVKLQGASKVD
DIWNLEVKGNFSGETASQRIYAIWEHNIKNHLQLEGLFLTSGEHTSKTTLDLSPWKMSAL
IQVNASQPSSLLEINYLLQEVSLNANTEHQKVSWKSEVQVHSGSLQNNVQLSNGQKEARL
DVAGSLEGYLRFFKDIVLPVYDKSLWDLLKLDVTTSIDRKQYLRASTALVYTKNPNKYSF
SIPVQELADKFI--IPGLKLNNLNSVLVTPAFQVPFTGHEVPSYTLDLSEIIIYKKLSTS
PFVLSIPTLPKVKFPEVDVLTKYSGPKDSSDPFFEITVPKSQLTVSQYTLPKNISIGNTV
LDLNEVASKIADFELPTITVREQTIEIPSITFSVPAEISIPSFGALTARFRVASPLYNAT
WSTGLENKKDRIETFLSSTCSSTIQFLEYDLDVVRTHKIEDGRLVYETNGTFAHRDFSAE
YKD-SKHQGLWDWKDEIQLNITSPTLTDVRLRYQSSEN-SLSSSAASPAIGTVAMHLGKD
N-GIFKWNF---FYR-PQSSPDKKLNIFKTELK--YQKF---YEIKVNWEEEAVS-KLLT
SLKDNAPKAVGALYDHVNKYHQEHTGLNLRDASLKLRRSLQNSADQAYQGAMRQIDEVD-
-MDLQRMAMGTTRTYEQWKDKAQNLYQELL-AQEGQADFQRLRNKTFDRLIRVTQEYCVI
FKHLSDSFIDYLNFTRFQLPGRAGTYTTDELCTMFMREVGSVLSQVHSKIHNGLEMLFSY
FQDLMEKSELIKDLKIKFPFDSRSHK---------LIDVILEYGKLLK----SVSQWVPK
AFNYLQSIKI-TEMLSDLQRSL-QSVCQEIEGEIEYLKEKKFTYLINDIQHEIKTIFNEY
ITYVFGYLKENLYLNFGKFN----ELVQNNLQEASQELQQLLQYVKAVHEEHFDPSIVDW
TVKYYELEEKVINLIKNLVDILKDFHFKYTVSAADFASQLSSQVEQFVQKDIQEYLSILA
DADGKGKEKIAELSTIAQEIIKSWAAAMKEIISDYHQ

PF12491 // ENSGT00590000083139_0_Domain_6 (4658, 4716)

QFIYKLQDFPDQLSDYYEKFIAE
SQRLIDLSIQIYHVFVKYIAELLKELQL-ATVNDMKSYIKNAPGEFTI------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------

-----------------------------------------------MGPRRPVLR----
------SPLLL-LFLLLFLDTSVWAQDEVLESTS-SNCPKDATR

PF01347 // ENSGT00590000083139_0_Domain_0 (105, 673)

FKHLRKYVYNYEAESS
SGIRGTADSRSATKINCKVELEVPQLCSFIMRTTQCTLKEVYGFNPEGKALMKKTKNSDE
FAAAMSRFEL-KLATPEGKQVVLYPDKDEPKHILNIKRGIISALLVPPETEEDKQVL---
LLDTVYGNCSTQVTVNSRKGTVATEMSTERN----LQQCEGFQPTSTSVSPLALIKGLVR
PLSTLVSSSQSC-QYTLDPKRKHVSEAICNEQHLFLPFSYKNKYGIMTQVTQTLRLEDTP
--KINSRFFNEG-TKKVGLAFESTKSTSPTKQ-TEAVLSTLRELKGLSVSEQNAQRANLF
NKLVTELRGLSEEAVASLLPQLIGLSS--PITLQALVQCGQPQCYTHILQWLKTEKAHPL
LVDIVTYLVALIPNPSTQRLREIFNTAKEQQSRATLYALSHVVNNYYD-ADLSRSRDL-Q
DVAGYLLKQIDNECTGNEDHTYLILRVIGNTGRTMEQVMPALKSSVLDCVRSTKPSLLIQ
KAAIQALRKMELGEEVKCILFDTFANGAAPVEKRLAAYLLLMRGPSSSEIRKIIELLQLE
QSEQVKNFVASH

ENSGT00590000083139_0_Linker_0_3 (673, 709)

IANILNSEELYVQDLKNLIESALEGSQ-LPTIMDFR

PF09172 // ENSGT00590000083139_0_Domain_3 (709, 1017)

RFSQNYQISKSV
SLPSFD-PVSAKVEGNLIFDPSSYLPKESMLKTTLTVFGLASADLFEIGLEGKGFEPTLE
ALFGKQGFFPDSVNKALYWVDGQVPDRVSKVLVDHFGYIKDDKHEQDMVNGIMPMVDKLI
KELKSTEIPEARAYLRILGEELGFVKLQDLQVLGKLLLSSAQTLRGIPQMIA-QAMRDGS
KNDLYLHYIFMDNAFELPTGAGVQLQVSSSGVITPGTKAGVRMELA-NIQAELVAKPSVS
VEFVTNMGIIIPDFAKSGVQMNTNFFHESGLEARVALKAGELKVTIPAPKRPVKLF

ENSGT00590000083139_0_Linker_3_5 (1017, 1044)

SGSN
TLHLVSTT----KTEEIPPLIEN

PF06448 // ENSGT00590000083139_0_Domain_5 (1044, 1156)

RQSWSTCRPFFTGMNYCTTG-AYSNASSTESASYYPL
TGDTRYELELRPTGEVDQYSASATYQLQKEDKALVDTLKVLVQAEGVQQTEATAVFKYNR
QSRTFSSEVLIPGFD

ENSGT00590000083139_0_Linker_5_6 (1156, 4658)

VDFGTILRVNDESARDKNAYKLILDIQNKKVTEVSFVGHVSYDRK
GDGKIKGVVSIPRLLAEARSEVHTHWSPTKLLFQMDSS--ATAYGSTISKRVAWRYDNEK
IDFNWNTGTNVDTKKVASNFPV----DLSSYPRTLHEYANRLLDQRVPQTDMTFRHMGSK
LTAATNIWLQMASRGLPYSQMLQDHLNGLSELNLQKMGLPDFHIPDNLFLKSDGRVKYTL
NKNSIKLDIPLPLSGKSSKDLKIPETVRTPALNFKSMGFQLPSQVFQLPTFTIPKTYQLQ
VPLLGVLDLSTNVYSNLYNWSASYTGGNTSR-D--HFSLRAQYRMKADSAVDLFSYSVQG
SGETTFDSRNTFTLSCDGSLHHKL-LDSKFKVSHVEKFGNTPVSKGL---LTFEASSALG
PQVSATVHLDSKKKQHLYVKDLKVDGQLRASSFYAQGKYGLSCERDPTTGQLSGESNMRF
NSTYFQGTNQIVATYQDGTLSVTSTSDLQDGIFKNTASLKYENYELTLKSDSSGQYENFA
ASNKLDMTFSKQSASLRSEHQANYKSLSLITLLSGSLTSQGVELNADILGTDKINTGAHK
ATLKIARDGLSTSATTNLKYSPLVLENELNADLGLSGASMKLSTSGRFKEHHAKFNLDGK
AALTEVSLGSMYQAMILGADSKNIFNFKLSREGLKLSNDMMGSYAEMKLDHTHSLSIAGL
SLDFSSKMDNIYSANKFYKQNFNLHLQPYSFLTTLSHDLRYNALDLANSGQLRLEPLKLN
VGGNFKGTYQNNELKHIYAISYTNLVVGSYRADT---IAKVQGTEFSHRLNADIKGLASS
VDVITNYNSEPLNFNNVFHFVLKPFTLGIDTHTSGDGKLALWGQHAGKLYSKFLLKAEPL
ALSFSHDFKGSTNHDLVYKSSISTALNHEATALLTPAEQTSTWKFETRLNDKVYRQDFEA
YNTKDKIGVELSGR--AELSEPSWPFKLPFFYSEPVSALDNSEINDAVDKPQEFTIVAFV
KYDKNQDVHTISLPFFKSLPEYLERNRRRIITLLEAVQGELQSINIDQYLRKYKAALSRL
PEQVHDYLNASDWEGQVTNAKEKLTAFMENYKITDNDVLIALDSAKINFNEKLSQLETYV
IQFDQYIKDNYDPQVLKKTIAQIIERIIEKLKILDEQYHIRVNLEKSIHNLYVFVENVDL
NKLGSSTASWIQNMDTKYQIRIQIQEKLQQLRTLIQTVDIQQLAAELKQQIEAIDVMMYF
DQLRTAILLQRVKNIIERVEYFVMSLIEDFKVTEKINT---IVRELIEKYEVNQQIQVLM
DKLVELAHSYSLGETLQKLSNVLQEIEIKDCYDKFVGFIDETVEWLKALSFKKFIEELNR
FLDMLVKTLKSFDYHQFIDETNSKLREMTQRINAEIHALELPQKTEAL-KLLVEDFKATV
SSYLERLKGTTVTVFFDWLQDAL-----VHIKDH---TLDDVRDIVYQIDIPWELERFLS
LVSQAYHTLVTYISDRWILTVKNITDFAEQYSIQNWAEHAKVLVEQGFTVPEIQTFLGTM
PAFEISLRALQEGTFQTPDFIVPLTDLRIPSIQINFRTLKNVKIPSRFSTPEFTILNTYH
VRSFTIDLLEIKAKIIRTIDQMLSSELQWPLPEVYLKDLGMVNIPLARLTLPDFQVPEIA
IPEFAIPNVSFKDFQVPDLHIPEFQLPRLSHTIEIPAFGKLHGVLKIQSPLFILDANANI
QNVST-SENKAEMVASVAAAGESKFEALNFDFQAQAQLLELKP--NPLVLKESMNFSSKY
VRMEHEGEMLFSGQAIEGKSDTVASFHIEKNTVEFNNGVTVRINNRLTLDSHTKYFHKLS
VPSLDFSSKASFNNEIKSLLEAGHVVWTSSGTGSWNWACPNFSDEGIHSSKVSFTVKGPI
ASFGLSNNINGKHLRVTQKLAYESGFLNYSKFEVESKVESQHVGSSVLTGKGTVLLRDAK
AEMTGEHNADFNGKVIGTLKNLLFFSAQPFMITASTNNEGNLKVSFPLKLTGKIDFLNNY
ALFLSPHAQQTSWQASARFNQYKYNQNFSAVNNEHNMEAHVGMNGDANLDFLNVPLTIPE
IS--LPYIGLTTPL-LKDFSIWEEAGLKDFLKTTRQSFDLSVKAQYKKNREKHSIVIPLS
MFYEFILNNVNSWDRKLEKVRDGALDFLTTSYNETKVKFDKYNTEKSLTRPLRTFQSHGF
TIPF---ANIDVSPFTVETLASSYVIPKAIRTPSVTIPGPKVIVPSYRLELP-SLELPVL
RAPGNLLRFSLPDLKKLSTIDNIYIPALGNFTYDFSFKSSVITLNTNAGLYNQSDIVAHF
LSSSSYVTDGLQYKLEGTSRLTQKRGPKLATAVSLT-NKFVKGSHDSTISLNKKNVEASV
KTTASLHVPVLTMNFKQELNGNAKSKPTVSSSMELNYDFSSSKLHSTAKGGVDHKFSLES
L-----ASYFSIESSAKGNIKGSVLS-QEYSGSVASEANTFLDSRGSRSSVKLQGASKVD
GIWNIEVGENFAGEATLPHIYATWEHSIKNHLHVDSFFVTKGKQTCKATLELSPWTMSTL
LQVHVSQPSSLLDLHHFDQEVTLKANAKNQKVDWKSEVQIHSRVLQHNVKFSNDQEEVRL
DVAGSTEGQLWDLESIILPVYDKSLQELLQMD-----GKKQYLQVSTSLVYTKNPNGYLL
SLPVEELADRFI--IPGLNLGG-------------------------FSGIKIYKKLSTS
PFALNLAMLPKVNFPGVDVLTQYSKPEDSSVPAFEVTIPEVQLTISPFTLPKNFPVGSAG
FDLKDIAQLIAGVDLPSTTLPEQTIEIPSFEFTVPTGVLIPLFGALTAHVGVASPVYNVT
WSAALKNKADHVETSLDSTCSSIWQFLEYDLKVVGTQKMEDRVFFYKNKGTLQHRDFNVE
YNEDGVFQGLWIWLGEAHLDITSPALTDLRLYYKEDEN-SLWAWAASPAIGAVGLESSTD
D-QRLRLNV---YFQ-PQSPLDRKLNIFKTEWR--YKKSDDGRYIKINWEDEAAS-RLLG
SLKSNVPKATATIYDYVNKY----A-------SSKLKRSLQNNAER----AIRTVNEMN-
-MDFQRAAH---DAYQEWKDKTQNLYEAML-AQEGQSITEGLQEKVVDSIVNVTQKYHVA
VALLTDSFIHFLKYNTFKLPGNAGTYTADELCTMVMGGMAKSLSC----VHNSLEKLLSY
VQDLVEKSGLFSDIKFRFPLVPKASE---------LKDVILEYRLLLN----ISSDFIQG
YFEDFQHVNF-TTILGDVQVVL-KEILGYVVKEIQYLCNKESDCFTNYINA-I---FKIH
IPSAFQFLKEELYSIFSDFN----DSVQSLLLEGSYKLQQVYHYIKALREEYFDPSMVGW
TVKYYEVEEKMVDLIKSLLVILKDFHSEYSARATDFVSNITTQVEQFVSRNIQEYLSILA
DIDGKGKEKIAELSITAKEAIKSWAPAMKEIIFDYHQ

PF12491 // ENSGT00590000083139_0_Domain_6 (4658, 4715)

QFSSKLQDFSDKLSDYYEKFIAE
STRLIDLSVQSYHVFLRYVTQLLKELQV-ATANNMSSYVKLAPGELIITF----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------EEVGLAFE

PF01347 // ENSGT00590000083139_0_Domain_0 (383, 674)

STRSTSTPKQ-AEAIVKTIQELQTLHVSEKNAQRANLF
NKLVTELRSLNNEAFTSLLPKLVKVSS--PITLQALIQCGQPQCYTHILQWLRSEKANPL
LIDVVTYLAALMPEPSAERLREIFSTAKEQQSRATLYALSHVVNNYHK-ANPVVTQDL-L
DIADYLLEQIHDDCTGNKDHTYLILRIIGNIGRTMETVTPRLTSSILKCIKSTEPSLLIQ
KAAIQALRKMELKDEVREVLLQVFLSDASPGDKRLAAYLMLMRDPSQSDMKQIIQLLPRE
QNEQVKNFVASHI

ENSGT00590000083139_0_Linker_0_3 (674, 709)

ANILNSEELHIKNLKKLVEEALKGSQ-LPTILDFS

PF09172 // ENSGT00590000083139_0_Domain_3 (709, 1025)

KFSRNYHLSKSV
SLPSLD-PISAKIEGNLIFDPNNYLPKESMLKTTLNVFGFAPADLFEIGLEGKGFEPTLE
ALFGKQGFFPDSVNKALYWVDDQVPDHVSKVLVDHFGYTKDDKREQDMINGIMLNVERLI
KDLKSREFPEARAYLRILGEELGFVRLHDLQLLGKLLLSGVRTLPGIPQMIG-EAIKKGS
MNDLFLHYIFMDNAFELPTGIGLQLQVSSSGVIAPGIRAGMKLDTA-NSQMELVTKPSVS
VEFVTNMGIIIPDFSRTMFQMNTNLFHETGLEMHVVFKAGQLKFIIPSPTMPVKLFSGRN
TVHF

ENSGT00590000083139_0_Linker_3_5 (1025, 1041)

ISTT----NTEEAPPL

PF06448 // ENSGT00590000083139_0_Domain_5 (1041, 1157)

KENREAWSDCKPLFTGLDFCTSSSHYTTTTSPEPASFYQL
SQDTRLELELKPTGEVELYSASVTYELQKEAGALVDTLTFLTQTEGAKQTEATMMFKYNR
QSMTLSSEIQIPDFDVDLGTILRVSDESAMEKKSYKLTLDLQNKKITEVTLTGHISYDRR
EEGKIKGVISIPRLQAEARSEILTQWSPTKLLLLMDSS--TTAYGLTISKKLVWRYDEEK
IEFEWNTGTNVDTKKAASNFPM----DFSDYPKSLHMYANSLLDHPVPQTDMTFRHMGSK
LIVATNTWLQKASSSLPYAHNLQDYLSGLKELYLQKMGLPDFHIPVNLFLKSDGRIKYTL
NKNTVKIEIPLPFGGKSSKDLKMLETIRTPNLNFKSIGFHLPSREFQVPTFTIPELYQLR
VPLLGVLDLSTNIYSNLYNWSASYTGGNTST-D--HLSLRAWYHMKADSVVDLLSYSVQG
SGETTYDHKNTFTLSCDGYLHHKL-LDSNMKFSHVEKIRNNPASKSL---LTFNASSAWG
PQMSASVHLDAKKKHHLYIKEAKIDGQFRVSSFYAEGTYDLSYQRDSTTDQLSGESNLRF
NSSYLQGTNQITGRYEDGTLSLTSTSDLQDGIIKNTAFLRYENYELILKSDTNGKHEDFA
ASNKVDMTFSKQNALLRSEYQADYKSLRFFTLLSGSLNSHGLELNADILGTDKINSGAHK
ATLRIAQDGMSTSATTNLKYSPLVLENELNTELGLSGASMRLTANGRFREHNAKFSLDGK
AALTEVSLGSAYQAMILGVDSKNVFNFKISQEGLRLSHDMMGSYAEMKLDYENNLNIAGL
SLDFSSKLENIYSSDKFYKQNVNVQLQPYSLVTTLKNDLKFNALDLTNSGKLQLEPLKVN
VGGNIKGVYQNNEIKHIYTISYADLS-ASYKTDT---VAKVQGTEFSHRLNTNIAGLAST
IDISTNYNSDSLHFSNVVHSAMAPFTMTIDGHTNGNGKLSLWGEHTGQLYSKFLLKAEPL
ALTFSHDYKGSVSHHLPLKSTISTTLDHKISALLTPAEQTGTWKLKTQLNQNEYIQDFNA
YNDKDRVGVELRGQALADLSLLDFSIQVPFLLNEHTNIIDALGMRDAVDQPQEFSVVASV
KYDKNQDVHTINLPFFEILPEYFEGKRMVIITALETIQRELKLIDVDQFVSKYRTALDKL
PQQVDSYLNALNWERQVLSAKEKLTALAENYRITENDLQIALDNTKISLNDKLSQLKTYV
IQFDQYINDNYDLRDFKTAIAKIIDQIIEKLKILDEQYHIHVNLVKIIHDVCLFIEKTDF
NRIGNSTALWIQNVDAKYKIKIQIQEKLQQLKTQIQNIDIQRLAEQLKQQVEAADVRDLL
HWLRITIPFQRIKEIIEHVKYYVINLMDGFEVAEKINVLRARSYQLIKMYGIDQYIQVLM
DKSVQLAHQYKLKETVQKLSSVLQQVKIKDHFEKLVTFIDNAIQQLKALSFKKIIEQVNR
FLDMLTNRLRSFDYHRFVDETNNKIREVTQRLNGEIQALELSQKAKAL-ALFVEDIKATV
LVHLEHLKGTQINLFFDRLQEALSSTSLIYMKEKFREILEDIRDRVYQMDIQQEVHWYLS
LVGQVYSTLVTYISDWWSLAAKNLTDFAEQYSIEDWAENLKSLVEQGFTVPEIQTTFGTM
PAFEVSLRALQEATFQTPDFIVPLTDLKVPSIQINFKRLKDIEMPSKFATPEFTVLNTFH
VPSFTIDLVEIKAKIIRTIDQMLHSELQWPVPEVDLRDLMGVDTILASITLPDFHLPEIT
IPEFIIPNLDFKDYQVPDLHIPEFQLPHMSHTLEVPTFGKLHSILKIQSPLFTLDANADI
QNVTT-SGNRAEITASLTAKGESKLEVLNFDFQANAQLSDPEI--NPLVMKQSMRLSSKY
LKTEHKSEVLFVGNTIEGKSNTVADLHTEKNTVELSHGALVRINNQLTLDSNAKYFHKLN
IPKLDFSSQAELRNEIKTLLEAGHIAWNSSGIGSWKWACHAVSDEGAHESQASFTMEGPI
TSFGWSNKINSKHLRLSQNLVYESGFLDFSKFEIQSQVESQHVGRSVLAAKGTAKLGERK
AEITGNHDAHLNGKVIGTLKNSLFFTAQPFEITASTNNEGNLKVSFPLKLIGKVDFLNNY
ALFLSPSAQQASWQASARFNQYKYHQNFSAGNNENSTEAHIGINGEANLDFLKIPLTIPE
MT--LPYTTFTTPQ-VKDFSLWEKTGLKGFLKTTKQSFDLSVKAQYKKNKDKHIIPIPF-
------------------------------------------------------------
------------------------------------------------------------
---------YTKDFQVLSTPNDIFIPAMGNITYDFSFKSGIITLNTNVGLYNQSDIVAHF
LTSSSSVTDALQYKLEGTSSLTRKRDLKLATALSLS-NKFVEGNHDSTISLTKKNMEASV
TTSAKVQIPILRMNFKQELNGNTKSKPTVSASIELTYDLNSAEQYSTATGTVSHKFNLES
L-----TSYFSIESSTKGDIKGSVFS-RKYSGTIASEASTYLNSKSTRSSVKLQGASKVD
GIWNLEVKENFAGEATLQRIYGIWEHNTKNNLQLEGFFSSSGEHTSKATLELSPWKMSAL
IQVHASQPSSLLEINYLGQEVSLKANAENQKVSWKSEVQVHSEFFQNNIQLSNDQEEARL
DIASSLKVSLGFLKDTVLPVYDKSLWDLLKLDVTTSIDRKQYLHASAAFVYTKNPNGYHF
SVPVQELADKFI--IPRLKLNDLNSSFVIPTFQVPFTDLQVPSYTFDFSEIKIYKKLNTL
PFALNIPTLPQVKVPKVDVLTKYSEPEDSSVPFFEITVPASQLTVSQLT-----------
------------LQLPAITIPEQTIEIPSIKFSVPAGIFIPSFGALTAHFGVASPLYNAT
WSTGLKNKVEYFETFLNSTCSSTIQFLEYDLNVVGTHKIEDGMLVCRTKGTFAHRDISAE
YKEDSKYQGLQDWKKEIRLDITSPTFTDVHLYHQLSEN-SLSSSVASPAIGTVALDLEDN
N-STFKWNL---YYR-PQSSLDKKLNIFKAEWK--YKEPGEKHQIKVSWEEEAAT-ELLS
SLKDNVPKATRVLYDYANKYHQEHTGLNLRDASLKLRGSLQNSAEWAYQGAMRQIDVVD-
-TGFQRVARGTARTYQQWKDKAQDLYQELLLAQGDQADFQGLQNEMFNRVIGVTQEYNIT
VSHQIDSLIEFLKLTRFQLPGKAGTYTKDEVCTVVMREVGQVLSQVYSKIHSGLEILFSY
FQDLMEKSELTKNLEIKIPFDSKRFK---------LIDVISESGTMLE----HFSEKLQD
IFNNLQSCKT-TEMLRDLQSYL-QRTSQEIENDIQVLKSIKFHSLIDHIQYNANGIFNES
IPYVFAPM----ELMFGKFN----EFVEKQLHEASRQLQKRHQIIKDLHKEYVDPSVVSW
TGRFYELEEKIISSLKNLMDVLKDMHASYTVGSIYLVSHISDQVQQFMQTDIQEYFSILT
DADGKGKEKIVELSTSAQEIIKSWAIAMKEIISDYRQQFTYKLQDFSDQLSDYYEKFITE
SKRLIDLSTQKYHMFLRYIIELLKELQS-ATVNNMIPYIKVSPGEFTI------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------

-----------------------------------------------MGPPRP-------
------ELLLPLLLLLLLP-NSHSSY----VADL-LLVVEEATR

PF01347 // ENSGT00590000083139_0_Domain_0 (105, 673)

FKHLRKYVYSYEAESS
SGIPGKADSRSITKINCKVELEVPQLCSFVLKTSQCTLKELHGLNLEGKALLKKTKNSED
FAAAMSRHEL-RLAFPEGKRVFLYPEEEEPKHILNIKRGIVSALLAPPETEEDTQEL---
FLDTVYGNCSTRVVVKTRKGNVATEMSTDRN----LQECTGFQPSSTGASPLALIRGLAR
PLSTLVSSSQSC-QYTLDPKRKHVSEAVCREQHLFLPFSYKNKYGMMTQVTQTLKLEDTP
--KINSRFFGEG-ALKVGLAFENTKSTFLPKQ-AEAVLKTLQELKKLTGFEPQVQRANLF
SKLVTNLRGLSSEDITSLLPRLIEVSS--PITLQALIQCGQPQCYTHVLQWLRSEKAHPL
LIDVVTYLVALIPDPSAQMLRETFNIAKEQLSRATLYALSHMVNNYFE-TTRTPNQDL-R
DIANYLQEQIQDECAGDEEHTYLILRVIGNMGRTLDNITPTIKSSILRCIGSSKPSMLIQ
KAAIQALRKMQLGDEAQQLLLQTFVDSASPGDKRLAAYLTLMKKPSQSDIGRVIQLLPRE
ENEQVKNFVVSH

ENSGT00590000083139_0_Linker_0_3 (673, 709)

IANILSSEELYIGGLKALVKEALKDSQ-LPTIMDFS

PF09172 // ENSGT00590000083139_0_Domain_3 (709, 1018)

KFSRNYQFSKSV
SLPSLD-PVSAKIEGNLIFDPNNYLPKESMLKTTLTAFGFASADLFEIGLEGKGFEPTLE
ALFGKQGFFPDSVSKALYWVNGQVPDGVSKVLVDHFGYTKDDKHEQDMINGIIPIVDKLI
KDLKSRDLPEARAYLRILGKELSFFRLQDLRLLGRLLLSGVHALRGIPQMV--KALREGW
RNDLFLYYIFMDNTFELPTGMGLQLQVSSSGVTTLGTKAGVKLEMA-KMQTDLVMRPSVS
VEFVTSIGIIMPDFARSGVRMNTNVFCGSSLEAHVALKAGELRFIVVSPKRPIKLFS

ENSGT00590000083139_0_Linker_3_5 (1018, 1044)

ISN
TLHLVSTT----KTEVLPPLIDG

PF06448 // ENSGT00590000083139_0_Domain_5 (1044, 1156)

KQSWVNCRPLIPGLNFCSTD-APSNASATESASYYPL
TGNIRYGLELRPTGDVEQYSVGATYELQREENALVDRLKFAIQAEGKKTTEATLVFKYNR
RSKTLSSEMQIPDLD

ENSGT00590000083139_0_Linker_5_6 (1156, 4658)

IDLGTILRVTDESSNDEKSYKLNLDFQNKKITEVAFTGHVSHDTN
GEGKIKGVISIPRLQAEARSEISTHWSPTKLLLHMDSS--ATAYGSAISKRVVWRYDDEK
IEFQWNTGTNVDTKKAAASFPV----DPSDYLRSLHMHANKLLDHRIPQTGMTFSEMGSK
LIVTTNTWLQEAANGLPYAQILQDHLSSLKELNLEKMWLPYFHLPDNLFLKSDGRIKYIL
NKNSIKVEIPLPFGGKSSRDLKMLETIRTPALSFKSLGFQLPSQEFQVPSFTIPEVYQLR
VPLLGVLDLSTNVHSNLYNLSASYTGGNTSR-D--HFRLQARYHIKADSVVNLLSYSLQG
SGETTYDHRNTFTLSCDGSLRHQL-LDSNVKLSHVEKIGNNPASKGV---LTFDISSTWG
PQMSASVHLDSKMKQQLFVKDVKIDGQLRASSFYAEGTYGLTCQRNPTTGQLRGESNLRF
NSSYLQGTNQMTGVYEDGALSLTSTSNLQGGTLKNTASLKYENYELTLKSDTSGNYENLA
TSNKVDLTFSKQNALLRSEYQADYKSLKFFSLLAGSLNSQGVELNADILGTDKINAGAHK
ATLRITRDGISTSATTNLKYSPLFLENELNAALGLSGASMKLAANGRFREHSAKFSVDGK
AALTEVSLASAYQAMLMGVDSKNVFSFRLSGEGLKVSNDLMGSYGEMTLDHANSLSIAGL
SLEFSSKLDNIYSADKFYKQNFNFQLQPFSLVTTLNNDLKYSALDLTSSGKLRLEPLKLN
VGGNLKAAYQNNEIKHIYTISYADLS-ASYKADT---LARIQGAEFSHRLSTGIAGLAAS
VDISTNYHSDSLRFNSAVHSALAPFTVAIDAHVNGNGKLALWGEHTGQLYSKFLLKAEPL
ALTFSHDYKGSTSHNLSSGKSISAALDHRLSALLTPTEQTSTWKLKTQLNNHEYSQDFDA
YNTKDKIGVELSGRGLADLTVLDFPIKVPLLLSEPINVIDALQMKDAIEQPQEFTVVAFV
KYDKNQDVHTISLPFLKTLPEYLERNRIIIITTLEIIQRELKRIDIDQFVKKYGAGLSKL
PQQVSEHLNALDWERQIACAKKKLTAFAENYRITENDLQTALNTVKINLNEKLSQFQTYV
MQFDHYIINNYDLRDVKRAIAKIIDQITKRLKSLDERYQIRVTLVRTIHSLYLFVENVDF
NKMASSTASWIQNVDTQYQIRVQIQEKLEQIRTQIQNLDIQELAAKLKQQVEAIDIRKLL
NQLRATIPVQKINTIIEHVKYFVINLINDFEVVEKINAFRAVAHELIKKYDIDRQIQVLI
DKSVQLAHQYKLKDMVQKLSNALQQVDIKDCYEKLLVFIDDIIRELKEFSFKTIIEDVNH
LLDILVKELRSFDYHQFVNETNDTIREVIQLAN-SY--LDLPQKAEAL-KLFIEDVKVML
SAFLEKLKDTKITLFVDWLQNALNS------------TLEDMRDRIYQMDIQHELERYLS
LVGQVYNTLVTYISDWWGLTAKNLADLAEQYSIQAWAANVTALVEQGFTVPKIQTFLGTM
PAFEVSLRALQQATFQTPDFVVPLTDLKIPSVRINFKELKDIKIPSRFSTPQFTILNTFH
IPSFTIDLKDIKVRIIRTIDQMLSSELRWPVPEVYLRDLKVENILPARLMLPDFSLPEIT
IPEFAIPNLNLSEFRVPDLHIPEFQLPPISHTAKIPAFGKLNSILKIQFPLFTIDAQANV
HNVTI-SEHQAGIEAFIGAKGESKFEIFNFDFQANAQLLEPMT--DPLLLKESMNFSSKY
LRMGHGSEIVFSTNAIEGKSGTVASFHTEKNTLELKNGMIVKIKDQLTLDSLTKYSHKLN
IPKLDFSSKAELINDVNTRLEAGHVTLTSSGAGSWKWACPNFSDEGTHESQISFTMKGPL
ASLELANKINSKHVRVTQNLAYESGFLNFSKFDITSDVESQHVGHSVLNAKGIALLDKGK
VEITGDHNAHLNGKVIGTLKNSLFVSAQPFEMTASANNEGNLKVSFPLKLTGKIDFLNNY
ALLVSPAAQQANWQASARFNQYKYNQNFSALNNENSIEAHVSINGDANLEFLNVPLTIPE
MN--VSYIALTTPS-LKDFNIWEATGLKEFLKTTKQSVDLNVKIQYKKNKDKHSIAIPLG
RFYKFINENVNSLDSYVANVRDNSLDFLTTAYKAVKFKWDEVRAEKSRNAPPRTFQYLGY
TIPV---ISIEVSPFSAEIWPFSHVIPKAINTSSSTVPSSDFSVPSYTLVLP-SIELPEL
YIPRNLFKLSLPDLKELSDVSSLFIPAMGNMTYDFSFKSSVITLNTNAGLYNQSDIVAHF
LSSSSFVIDALQYKLEGTLRLTRKRGLKLATALSLS-NKFVEGSHDSTISFTKKNMEASL
TTSAKVHVPVLRMNFKHELNGNTKSKPAASSSIELKYDFNAPEMFPTAKGAIDHKLSLES
L-----TSYFSIESSTKADIKGLVLS-REYSGALASEASTYLNSKATRSSVKLQGSSKVD
GIWNVEVKENFAGEATPLRIYTMWEHSMKDRLRPL--LSTHGEHTSKATLELFPGAVSAL
IQVRARQLSSLFDIPHVGQEVVLNANTENQKFGWKSEVQIHSGTLKNSLQLSNDQKEARF
DIAGTLEGHLHFLKFINLPVYDKSLWDLLKLD-------RQHLHAATALVYTKNPKGFPL
SAPVQELTDKFV--IPGLKLNDPE--------------------------IKIYKKLSSS
PFAVSLPKLPKVKVPQVNVFTKYSEPGNSSVPYFEITVPEVQLTVSQFTLPKSLRIAGAV
LDLNKVASTIGDFELPTITVPEQTIEIPSIKFSVPAGVFLPLFGALTARFGVASPLYNAT
WNVGLKNNADHVETFLDSTCSSTLQFLEYDLNVVGTYKIDDAMLSYKIKGTLDHSDLSAE
YEEDGKYKGLEDWEGEASLDFRSPAFTELHLRYQEDRN-SMSSSAASPAIGTVGLDLETE
GDRSFKCNL---YFQ-PQSSSDKKLTILKMDWK--YQESGDKTQMRFNWEEEAAS-RLLS
SLKDNVPKATGALYDYADKYHQEYTGLNLKD------RSVRESAEGAFRTLEELEAEVQ-
-TA--------------ASSTTGDLYQDLL-AEEGQNNSQRLKDEVFDSLIQVTHKYHKA
AKHLIHSFIDFLKLTRIQLPGMNGTYTRDELCTIVMREIGKILSQVYSNLQNGLEKLLSY
TQDLVEKSEVIRDLQIELPYDAGRYK---------LTEVILNCRKLLE----YLSQE---
------SIKF-SEKLSDLQSFL-QIVFQEIEAEIKSLKETRLSHLTNT----VREVINTY
IPFTYGVLKEGLSLHINEL-------VEFYLQTTSQGLLQIHHYVKALREEYFDPSIIGW
TVKYYELEEKIVDLIKHLAASLKDLHSMYTAHATKFASQLSTQVERFV----QEYLSIFV
DADGKGRVKIAELSNTTQEGIQTLTTAMKEIVSDYQK

PF12491 // ENSGT00590000083139_0_Domain_6 (4658, 4713)

QFTSKLQELSDQFSDYHEKVIAL
FQGLIDLSIENYHMLLRYITEVLAKLQA-ATAKGGSPSIQLTSGELIITI----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------

-----------------------------------------------MGPRRPALR----
------PPLLL-LLLLLFLDTSVWAREVALGLMYFLLTVEDATR

PF01347 // ENSGT00590000083139_0_Domain_0 (105, 673)

FKHLRKYVYNYEAESS
SSVRGTADSRSATKINCKVELEVPQLCSFVMRTSQCTLKEVYGFNPEGKALMKKTKNSDE
FATAMSKFEL-KLAISKGKQVVLYPDNDEPKHILNIKRGIISALLVPPETEEDKQVL---
FLDTVYGNCSTQVTVNSRKGTVATEMSTDRN----LQQCDGFQPISTAVSPLALIKGLVN
PLATLVKSSQSC-KYTLDPKRKDVSQAICNEQHLFLPFSYKNKYGIMTHVTQTLSLEDTP
--KINSRFFNEG-TKQVGLAFESTKSTPPPKQ-ADAVLNTLRELERLSVSEQNAQRANLF
NKLVTELRGLGDEAIRSLLPQLIGVSS--PITLQALVQCGQPQCYTHILQWLKTEKAHPL
LIDIVTYLVALMPNPSTQRLQEIFNTAREQQSRATLYALSHVVNNYYT-VDHSSSTDL-Q
DIANYLLKKIDNECMWDEDHTYLILRVIGNTGRTMEQVMPALKSSVLNCVRSKKPSPLIQ
KAAIQALRKMELGDEVK-ILFDTFADSAIPVENRLAAYLLLMKGPSSSDMSRIIQLLQWE
QSEQVKNFVASH

ENSGT00590000083139_0_Linker_0_3 (673, 709)

IANILNSEELYVQDLKNLIKNALEHSQ-LPTIMDFR

PF09172 // ENSGT00590000083139_0_Domain_3 (709, 1017)

KYSRNYQISKSV
SLPSFD-PVSAKMEGNLIFDPSSYLPKESMLKTTLTIFGLTSTDLFEIGLEGKGFEPTLE
ALFGKQGFFPDSVNKALYWVNGQVPDRVSKVLVDHFGYTRDDKHEQDMVNGIMPMVDKLI
KDLKSKEIPEARAYLRILEEELGFVKLQDLQVLGRLFLNGAQTLRGIPQMIA-QAIRDGS
KNDLFLHYIFMDNAFELPTGVGLQLQVSSSGVITPGIKAGVRMELA-NIQAELVAKPSVS
VEFVTNMGTIIPDFAKSGVQMNTNFFHESGLEARMALKAGQLKVVIPAPKRPIKLF

ENSGT00590000083139_0_Linker_3_5 (1017, 1044)

SGSN
TLHLVSTT----KTEMIPPLVEN

PF06448 // ENSGT00590000083139_0_Domain_5 (1044, 1156)

RQSWSTCKPFFTGMNYCTTG-AYSNASTTESASYYPL
TGDTRYELELKPTGEVEQYSASATYEFQKEDK--VDTLKFLVQAEGVQQSEATAVFKYNR
RSRTLSSEVLIPGFD

ENSGT00590000083139_0_Linker_5_6 (1156, 4658)

VDFGTLLRLNDESAKDKNAYKLILDIQNKKITEVALVGHVSYDRR
VDGKIKGVISIPRLQAEARSEIHTHWSPTKLLFQMDSS--ATAYGSTISKRVAWRYDNEK
IEFDWNAGTNVDTKKVASNFPV----DLSSYPRTLHEYANGLLDHRVPQTDMTFRHMGSK
LIVATNTWLQMASRGLPYSQMLQDHLNGLSELNLQKMGLPDFHIPDNLFLKSDGRVKYTL
NKNSIKLEIPLPLGGKSSKDLRMPESVRTPALNFKSVGFHLPSQTFQVPTFTIPKTHQLQ
VPLLGVLDLSTNVYSNLYNWSASYTGGNTSK-D--HFSLRAQYRMKADSAVDLFSYSVQG
SGETTYDSQSTFTLSCDGSLHHKF-LDSKFKVSHVEKFGNTPVSKGL---LTFEASSPLG
PRMSATVHLDSKKKQHLYVKEIKVDGQFRASSFYAQGRYGLSCERDPTTGQLSGESNIRI
NSTYLQGTNQIVGVYQDGTFSLTSTSDLQDGIFKNTASLKYENYELTLKSDSSGQYENFA
ASNKLDLTFSRQSASLRSEHQANYKSLRLVTLLSGSVTSQGMELNADILGTDQINTGAHK
ATLKITRDGLSTSATSNLKYSPLLLENELNAELGLSGASMKLSTNGRFKEHHAKFSLDGK
AALTEVSLGSIYQAMILGADSKNIFNFKLSREGLRLSNDMMGSYAEMKLDHAHSLSLAGL
SLDVSSKMDNIYSADKFYKQNFNLQLQPYSFVAALSSDLRYNALDVANSGRLRLEPLTLN
VGGNFKGTYQNHELKHIYTISYADLIVASYRADT---VAKVQGVEFNHRLNADINGLASS
VDVITNYNSDPLHFNNVFHLVLKPFQLGIDTHTSGDGKLALWGEHTGQLYNKFLLKAEPL
ALTFSHDFKGSTNHDLVHKSSISTGLEHTVSALLTPAEQTSRWKFKTRLNDKVYSQDFEA
YNTKDKIGVELRGR--ADLSGLDSPIKVPFFHSEPDNVLNDLEINDAVDKPQEFTIVAFV
KYDKNQDVHTISLPFFKSLPEYLERNRRGIITLLEAMQGELQRIDIDEFVRKYKAALSRL
PRQIHDYLNASDWERQATNAKEKLTAFMENYKITDNDVLIALDSAKINFNEKLSQLETYV
IQFDQYIRDNYDPQDFKKAIAQIIDRIIETLKILDEQYHIRVNLEKSIHNLYLFVENVDL
NKIGSSAASWVQNVDTKYQIRIQIQEKLQQLRTQIQTIDIQQLAADLKQQVEAIDVTKHL
DQLRTAILFQRINDIIERVQHFVRNLIEDFKVTEKINTFRAIVHELIEKYEVDRQLRVLM
HESVELAHRYSLGEALQKLSNALQQIEIRDYYEKFVGFIDDAVKQLKALSFKNVIQELNR
YLDMLVKMLKAFDYHQFIDETNSKIREVTRRINVEIQALELPQKTEAL-KLLAGDFKATV
SAYLERLKNTKVTVFIDWLQDAL-----VHIKAHFQDTLEDVRDRLYQMDIQWELEHFLS
LVSQVYNTLVTYISDWWILTAKNITDFAEQYSIQNWAESVKRLVEQGFTVPEIRTFLGTM
PAFEVSLRALQEANFQTPDFIVPLTDLRIPSIQINFKTLKNVKIPSRFSTPEFTLLNTFH
IPSFTIDLLEIKAKIIRTIDQMLSSELQWPLPEVYLRDLEMVNIPLARLTLPDFHIPEIT
IPEFTIPNVNFKDFQVPDLHIPEFQLPRLSHTIEIPAFGKLHGILKIQSPLFTLDANANI
QNVTT-SQNRAQIVASVAATGESKFEALNFDFEAQAQFLELNPNPNPLVLKESMNFSSKH
VRMEHEGEILFSGKAIEGKSDTVASLYTEKNTVEFNNSVIVKINNQLTLDSHTKYFHKLS
IPRLDFSSKASFNNEIKTLLEAGHVAWTSSGTGSWNWACPNFSDEGIHSSKISFTVEGPV
ASFGLSNNINGKHLRVIQKLAYESGFLNYSKFEVESKVESQHVGSSILIGKGTVLLRDAK
AEMTGQHHADLHGKVIGTLKNSLFFSAHPFTITASTNNEGNLKVSFPLKLTGKIDFLNNY
ALFLSPHAQQASWQAGARFNQYKYNQNFSAINNEHNMEARVGMNGDANLDFLNIPLTIPE
IT--LPYTGLTTPL-LKDFSIWEETGLKEFLKTTKQSFDLSVKAQYKKNRDRHVFMIPLS
TFYEFILNNVNSWDRKFEKVRDSALDFLTTSYNEAKIKFDKYKTENSLIQPPRTFQSHGY
TIPF---VNIEVSPFAVETMGSSHVIPKAISTPSVTIPGPNVIVPSYRLVLP-SLELPVL
HFPRNLLKFSLPDFKELSPIDNIYIPALGNFTYDFSFKSSVITLNTNAGLYNQSDIVARF
LSSSSFVTDALQYKLEGTSRLTQKRGLA--IAVSLT-NKFVKGNHDSTISLTKKNMEASM
KTTASLHVPILTMNFKQELNGNVKSKPTLSSSIELNYDFNSSKLHSTAKGGINHKFSLES
L-----TSYFSIESSTKGNIKGSVLL-QEYSGSVASEANTYLNPKGTRSSVRLQGASVVD
GIWNIEVGENFAGEATLRRIYATWEHSIKNHLQVDNFFVTKGKQMCRATLELSPWTMSTL
LQVHVSQPSSLLDLHHFDQEVTLKANTNNQKVIWKSEAQINSQVLQHNVQFSNDQEEVRL
DIAGSTEGQ-----TIFLPVY---LQKLLQMD-----GKRQYLQASTSLVYTKNPRGYLF
SLPVQELADRFI--IPGLKLND-------------------------FSGIKIYKKLSTS
PFALNLTMLPKVNFPGIDVLTQYSKPEDSSVPAFEVIIPEVQFIVSQFTLPKSFPVGNAG
FDLNEIANMIAGVDLPSVTLPEQTVEIPPVKFSVPAGIFIPFFGALTTHVGVASPVYNVT
WSAGLKNKADHVETSLDSTCSSIWQFLEYDLKVVGTHKIEDHMFICKNKGTLQHRDFTVE
YKDDGVFKGLWVWQGEAHLDITSPVLTELHLHYKEDEK-SLSASAVSPAIGTVGLESSRD
D-QSVELNV---YFL-PQSPLDRKLSIFKTEWR--FKKSEDGKHIKINWEEEAAS-RLLG
SLKSNVPKATEAIYDYVNKYYLGNA-------SSELRRSLQNNAES----ARKKIYKMN-
-MDFQKAAH---D--------TQNLYEEML-AQEGQSIPERLQDTVVDSLVYVTHKYHMA
VTFLTDSFIHFLKNNTFQLPGNGGMYTIDELCTMVMRETLKSLSQLCSSFYGSLEKLLSY
VQDLAEKLGLINDIKFKFPFVSKASK---------LPDVILEYRKLLN----ISSDLIQE
YSKVFQNTNF-TEILSDLQIIL-ERILDITEENIQCLNNKEYACFTDYINT-I---FKIH
IPNALKFLRKELYPICSEIN----DSVQSILQEGSYKLQQVHQYIKALREEYFDPSMVGW
TVKYYEVEEKVVDLIKSLLVILRDFYSEHSARAIDFASKITTQVEQFMPRDIQECLSILA
DINGKGKEKIAELSIMAKETIKSWPTVMKGTISEYHQ

PF12491 // ENSGT00590000083139_0_Domain_6 (4658, 4714)

QFSSKLQDFSDQFSDYYEEFIAE
STRLIDLSIQSYHEFLRYITKLLKELQV-ATANNVSPYIKLAPGELIITF----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------

------------------------------------------------------------
------------------------------------------------------------
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PF01347 // ENSGT00590000083139_0_Domain_0 (181, 674)

LSLSRGRYEL-RLTTPEGEQVLLYPEKEEPKHILNIKRGIISALLVPPETREAKQVL---
FLDTVYGNCSSDLTVQTRTGNVATEISIERN----LQKCDHFKPISTGVSPLAFVKGMIR
PLSTLISSSQSC-QYTLDPKRKHVSEATCKEQHLFLPFSYKNKYGMMAHVTQSLKFGNTS
--KINSRFFGEG-AEEVGLAFESTKSTSPPKQ-AE-VLKTLQDLENLSVSEQNAQRANLF
SK-VTELRGLSNEAVTSLLPRLIEVSS--PITLQALVQCGQPQCYNHILQWLKSKEAHPL
LIDIITYLMALIPEPPEERVREIFNTAKEQQSRATLYALSHVVNNYHK-IAPQRTQIL-L
DIEDYLLAQIHNDCTGDKDHTYLILRVIGNMGRTMEQVSPRLSSSVLKCIESTEPSLLIQ
KAAIQALRKMGSNEEIQEALLQAFFDGASPVDKRLAAYLMLMRGPSQADVNRIVQLLPWE
QNDQVKNFVASHI

ENSGT00590000083139_0_Linker_0_3 (674, 709)

ANILNSEELYIQDLKTLLEEALKGSQ-LPTIMDFK

PF09172 // ENSGT00590000083139_0_Domain_3 (709, 1025)

KFSRNYHFSKSV
SLLSLD-PISAKIEGNLIFDPNNYLPRESMLKTTLTVFGFSPADLFEIGLEGKGFEPTLE
ALFGKQGFFPDSVNKALYWVDGRVPDQVSRVLVDHFGYTKDDKHAQDMVNGIMLNVEKLI
KDLKSKEVPEARAYLRMLGEELGFVKLNDLQFLGRLLLSGIHILQGVPRMIG-EAISKGS
KNDLFLHYIFMDTAFELPTGAGLQLQVSSSGVITPGMKAGVKLEVA-SMQAELVAKPSVS
VEFVTNVGIIIPDFARSGVQMNTNFFHESGLEARVALKAGQLKFIVPSPKRPVKLFSGSN
TLHL

ENSGT00590000083139_0_Linker_3_5 (1025, 1041)

VSTT----KTDMILPL

PF06448 // ENSGT00590000083139_0_Domain_5 (1041, 1157)

IENRQTWSNCKPFFVGLNYCTSG-AYTNASSTDSASYYPL
TGETRFELELQPTGEVEQYSASATYELQREG-TVVDTLKFVTQAERLEQAKATMMFKYNR
QSMTLSSGIQIPDFSVDLGTVLRVSDDSAKDKKSYKLTLDIQNNKITEVTLTGHVSYDSK
EEGKIKSVISIPHWQAEARSEILARWSHTKLFLQMDSS--ATAYGSMISKKVAWRYDEEK
MEFEWNAGTNVDTKKVASNFPL----DLSDVSRSLHTYANSLLDHRVPQTDMTFRHMGSK
LIAATNTWLQEAPRNLPYAQTLQDHLSGLEEMNIQKMGLPDFHIPENLFLKSDGRIKYTL
NKNSVKIEIPLPFGGKSSKDLKILETVQTPALDLKSVGFHLPSQEFRIPSFTIPKFYPLR
VPLLGVLDLSTNVYSNVYNWSASYTGGNTST-D--HLSLKAQYYMKASSVVDLFSYSVQG
SGETTYNHRNTFTLSYDGSLHHKF-LDSNIKLSHVEKSGNSPASTCS---LIFEAASAWG
PQMSALVHLDSKKKQHLYIKEVKVDGQFRASSFYTKGSFGLSYQRDLNTGQLSGESNLRF
NSSYLQGTNQVTGSYKDGAVSFTSTSDLQGGLLKNTASLKYENYELTLKSDTTGKYKDFA
TSNKVDVTFSKQNALLRSEYQADYKALRFFTLLSGSLNSHGLELNADILGTDKINSGAHK
ATLRIGQDGMSTSATTNFRYSPLVLENELNAGLGLSGASVKLTTSGRFREHNAKLNLDGK
ATLTEVSLGSAYQAIILGVDSKNIFSFKINQEGLKLSNDMMGSYAEMKLDYTNSLNIAGL
SLDFASKLDNVYSSDKFYKQNFNLHLQPYSLVTTLNNDLKYKALDLTNSGRLRLEPLKLN
VGGNIKGTYQNNEIKHIYTISYADLS-ASYKADT---VAKVQGVEFNHRLNTDFAGLASA
IDISTNYNSDSLHFSNVFHSTMAPFTMTIDAHTNGNGKLGLWGEHLGQLYSKFLLKAEPL
ALTFSHDYKGSTSHHLVYKTSIDTALDHKVSALLTPTEQTGTWKLKTQLNKNEYNQDFDA
YNTKDKVGIELSGRGLADITMLDSPIEVPFLLSEPVNVIDALGMRDVSDQPQEFTIVASV
KYDKNQNVHIINLPFLKILPEYFERNRIAIIAVLESMQRELKHININQFARKYKAALDKV
PKQVTDYLNAFNWEARVTNAKEKLTAFTKNYKITANDLQIMLDNAKINLNEKLSQLQTYV
IQFDQYIKDNYDLHDFKLAVAKIIDQIIEKLKILDEHYHIHVNLIKTIHDLYLFVEKIDF
NKTGSSTAAWIQNVDTKYKIRIQIQEKLQELRTQIQNIDIQNLAEKLKQQVEIIDIRVLL
DPLRTTIPIQRIKDIIEHVKYFVINLTEDFEVAEIINAFTAKVRELIKKYEVDQQIQVLI
DKSVELVHQYKLKETLQRLSNALKRVEIKAYFEKLVEYVDDNVKKLKVLNFENFIEEVNR
FLDMLVKKLRSFDYNQFVDETNNKIRELTQKINHEIQALELPQKARAL-KLFTEKVKAVI
SVYLEDLKDAKITFLLDWLQDAFSSASLIYMKGKLQETLEDIRDRIYQMDIQQELQRCLS
LISQVYSTLVTYISDWWILAAKNLTDFAEQYSIQDWAEKLKRLIEQGFTVPEIQTMLGTM
PAFEVSLRALKGATFQTPDFIVPLTDLRIPSVEINFKTLKDIKIPSRFTTPEFTVLNAFH
ISSFTIDLVEIKVKLIRTIDQMLNSELQWPVPEVYLRDLKVNDTFLARIALPDFYLPEFT
IPEFVIPNLNLKDFDAPNLHIPEFQLPHISHTIQVPTFGKLYGILKIQSPLFTLDTNASI
QNVTT-SVNKAEIVASFTAKGESKLEVLNFDFQANAQLSGSEI--EPMVVKESVKLSSKY
LKTEHASQVLFSGKAVEGQSDTMTSLHTEKNTLELSNSVLLKINQQLTLDSNTKYSHKLN
IPKLDFSSQADLRNEMKTLLEAGRITWTSSGTGSWKWACPKFSDEGTHESRISFTVEGPI
ASFGLSNKINCKHLRVNQNLICESGFLNFSKFEIQSQIESQHVGHSVLTAKGTALLGDMK
AEVTGNHDARLNGKVIGTLKNSLLFSAQPFEITASTNNEGNLKVSFPLRLTGKVDFLNNY
ALLLSPNVQQASWQANARFNQYKYNQNFSAANNENSMEAHIGMNGEANLDFLNAPLTIPE
MT--LPYTTLTTPQ-LKNFSLWERTGLKEFLRTTKQSFDLSIDAQYKKNKERHSIPIPLN
VFYEFISQNIISFNKHFEKGKDNALDFLTKSYD---------------------------
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-----------------------------------------------MGPPRPALL----
AL---PALL-LLLAGARAEKE----M---LENVS-PVCPRDTTR

PF01347 // ENSGT00590000083139_0_Domain_0 (105, 673)

FKHLRKYTYNYEAESS
SGVPGTADSRSATRINCKVELEVPQLCSFILKTSQCTLKEVYGFNPEGRALLKKTKNSEE
FAAAMSRYEL-KLVIPEGKQVFLYPEKDEPTHILNIKRGIISALLVPPETEETKQVL---
FLDTVYGNCSTHFTVKTRKGNVATEISTERD----LGQCDRFKPIRTGVSPLALIKGMTH
PLSTLISSSQSC-QYTLDAKRKHVAEAICKEQHLFLPFSYKNMYGMGVQVTQTLKLEDTP
--KINSRFFGEG-TKKVGLAFESTKSTSPPKQ-AEAVLKTLQELKKLTISEQNIQRANLF
HKLVTELRGLSEEAVTSLLPQLIEVSS--PITLQALVQCGQPQCSTHILQWLKRVHANPL
LIDVVTYLVALIPEPSAQQLREIFNMAREQRSRATLYALSHAVNNYHK-TNPTGTQEL-L
DIANYLMEQIQDDCTGDEDYTYLILRVIGNMGQTMEQVTPELKSSILKCVQSTKPSLMIQ
KAAIQALRKMEPKDEDQEVLLQTFLDDASPGDKRLAAYLMLMRSPSQADINKIVQLLPRE
QNEQVKNFVASH

ENSGT00590000083139_0_Linker_0_3 (673, 709)

IANILNSEELDIQDLKKLVKEALKESQ-LPTVMDFR

PF09172 // ENSGT00590000083139_0_Domain_3 (709, 1017)

KFSRNYRLYKSV
SLPSLD-PASAKIEGNLIFDPNNYLPKETMLKTTLTAFGFASADLFEIGLEGKGFEPTLE
ALFGKQGFFPDSVNKALYWVNGQVPDGVSKVLVDHFGYTKEDKREQDMVNGMMFTVQKLI
EDLKSKEVPEARAYLRILGEELGFARLHDLQLLGKLLLTGARTLQGIPQMIG-EVIRKGS
KNDFFLHYIFIENAFELPTGAGLQLQISSSGVTAPGIKAGVKLEVA-NMQAELVAKPSVS
VEFVTNMGIIIPDFARSGVQMNTNFFHESGLEARVALKAGQLKFIIPSPKKPVKLL

ENSGT00590000083139_0_Linker_3_5 (1017, 1044)

SGSN
TLHLVSTT----KTEVIPPLIEN

PF06448 // ENSGT00590000083139_0_Domain_5 (1044, 1156)

RQSLSVCKQLFTGLNYCTSS-AYSNASSTDSAPYYPL
TGDTRLELELRPTGEVEQYSVSATYELQREDRALVDTLKFVTQAEGVKQTEATMTFRYNR
QSMTLSSEVQIPDFD

ENSGT00590000083139_0_Linker_5_6 (1156, 4658)

VDFGTILRVNDESTEGRKSYRLTLDIQNKKITEVTLMGHLSCDTK
EEGKIKGVISVPRLQAEARSEIIAHWSPAKLLLQMDSS--ATAYGSTVSKRVAWHYDEEK
IEFEWNTGTNVDTKKMTSNFPV----DLSEYPRSLHMYADRLLDHRVPQTDMTFRHVGSK
LIVAMNSWLQKASGSLPYTQTLQDHLNSLKELNLQNMGLPDFHIPENLFLKSDGRVKYTL
NKNSLKVEIPLPFGGKSSRDLKMLETVRTPALHFTSVDFHLPSREFQVPTFTIPKLYQLQ
VPLLGVLDLSANVYSNLYNWSASYTGGNTST-D--HFSLQARYHMKADSVVDLLSYNVQG
SGEATYDHKNTLTLSCGGSLRHKF-LDSNIKFSHVEKLGNNPVSKGL---LIFDASSSWG
PQMSASVHLDSKKEQHLFVKEVKIDGQFRVSSFYAKGTYGLSCQRDPNTGRLNGESNLRF
NSSYLQGTNQITGRYEDGTLSLISTSDLQSGIIKNTASLKYENYELTLKSDTNGKYENFA
TSNKMDMTFSKQNALLRSEYQADYESLRFFSLLSGSLNSHGLELNADILGTDKINSGAHK
ATLRIGQDGVSTSATTNLKYSPLVLENELNAEIGLSGASMKLTTNGRFREHNAKFSLDGK
AALTELSLGSAYQAMILGVDSKNIFNFKISQEGLKLSNDMMGSYAEMKFDHTNSLNIAGL
SLDFSSKLDNIYSSDKFYKQTFNLQLQPYSLVTTLNNDLKYNALDLTNNGKLRLEPLKLH
MAGNLKGAYQNNEIKHIYTISSAALS-ASYKADT---VAKVQGVEFSHRLNTDIAGLASA
IDISTNYNSDSLHFSNVFHSVMAPFTMTIDTHTNGNGKLVLWGEHTGQLYSKFLLKAEPL
AFTFSHDYKGSTSHHLMSRKSISTSLEHKVSALLTPAEQTGTWKLKTQFNNNEYSQDLDA
YNTKDKIGVELSGRALADLTLLDYPIEVPLLLSEPVNVIDALEMRDAVEKPQEFTIVAFV
KYDKNQDVHTINLPFFETLQEYFERNQRTIIVVLENMQRHLKRINIDQFVRKYRAALGKL
PQQANDYLNSFNWERQVSRAKEKLTALTKKYRITENDIQIALDDAKINFNEKLSQLQTYM
IQFDQYIKDNYDLHDLKIAIANIIDQIIEKLKSLDEHYHIRVNLVKTIHDLHLFIENIDF
NKIESSTASWIQNVDTKYQIRIRIQEKLQQLKRHIQNIDIQHLAGKLKQHIEAIDVRVLL
DQLGTTISFERINDVLEYVKHFVINLIGDFEVAEKINAFRAKVHELIERYEVDQQIQVLM
DKLVELAHQYKLKETIQKLSNVLQQVKIKDYFEKLVGFIDDAVKQLDELSFKTFIEDVNK
FLDMLIKKLKSFDYHQFVDETNNKIRELTQRLNGEIQALELPQKAEAL-KLFLQETKATV
AMYLESLQDTKITLIIDWLQDALSSASLAHMKAKFRESLEDTRDRIYQMDIEQELQRYLS
LVGQVYSTLVTYISDWWTLAAKNLTDFAEQYSIQDWAKHVKALVEQGFTVPEIKTILGTM
PAFEVSLQALQKATFQTPDFIVPLTDLRIPSVQINFKELKDIKIPSRFSTPEFTILNTFH
IPSFTIDFVEIKVKIIRTIDQMLNSELQWPVPEVYLRDLKVEDIPLARITLPDFHLPEIA
IPEFVIPNLNLNDFQVPDLHIPEFQLPHISHTIEVPTFGKLYSILKIQSPLFTLDANADI
GNGTT-SANEAGIAASITAKGESKLEVLNFDFQANAQLSNPKI--NPLALKEFVKFSSKY
LRTEHGSEMLFFGNAIEGKSNTVASLHTEKNTLELSNEVIVKINNQLTLDSNTKYFHKLN
IPKLDFSSQADLRNEIKTLLEAGHIAWTSSGKGSWKWACPRFSDEGTHESQISFTIEGPL
TSFGLSNKINSKHLRVNQNLVYESGSLNFSKLEIQSQVDSQHVGHSVLTAKGTALFGEGK
AEFTGRHDAHLNGKVIGTLKNSLFFSAQPFEITTSTNNEGNLKVSFPLRLTGKIDFLNNY
ALFLSPSAQQASWQVSTRFNQYKYNQNFSAGNNKNIMEAHIGINGEANLDFLNIPLTIPE
MP--LPYTTITTPP-LKDFSLWEKTGLKEFLKTTKQSFDLSVKAQYKKNTHRHSITNPLA
VLYEFTSQNIKSFDKHFEKARNNALGFVTKSYNDAKIKFDKYKAEKSHDELPRTFQIPGY
TVPV---VNVEVSPFTVEMSAFGYGIPKAVSMPSFTILGSNIRVPSYTLILP-SLELPVL
QVPRNL-KLSLPDFKELCTISHIFIPAMGNITFDFSFKSSIISLNTNAEVFNQSDIVAHL
LSSSSSVIDVLQYKLEGTTRLTRKRGLKLATALSLS-NKFVEGSHNSTVSLTKKNMEASV
ATTAKVQIPILRINFKQELNGNTKSKPTVSSSMEFKYDFNSSMLYSTAKGAVDHKLILES
L-----TSYFSIESSTKGDVKGSVLS-RDYSGTIASEANTYLNSKSTRSSVKLQGTSKID
DIWNLDVKENFAGEATLQRIYSLWEHSMKNHLKLEGLFFTNGEHTSKATLELSPWEMSAF
VQVHASQPNSFLDIPHLGQEVALNANTKNQKIRWKNEVRVHSGSFQNHVELSNDQEKAHL
DIAGSLEGHLRFLKNIILPVYGKSLWDFLKLDVTTSIGRSQHLRVSTAFVYTKNPNGYSF
SIPVKVLADEFI--IPGLKLNDLNSVLVMPTFHVPFTDLQVPSYKLDFREIKIYKKLRTS
SFALNLPALPEVKFPEVDVLTKYSQPEDSLIPFFEITVPESQLNVSQFTLPKSVSVGSAV
LDLNVVANKIADFELPTIIMPEQTIEIPSIKFSVPAGIFIPSFQALTARFEVDSPLYNAT
WRASLKNKADHVETVLDSTCSSTMQFLEYKLNVVGTHRIEDDMLASKTKGTFAHHDFSAE
YEEDGKYKGLREWERKVHLDIKSPAFTDLHLRYQKDKK-GISTSAASPAIGTMGMDV---
--DFSKWNI---YYS-PQSSPDKKLTIFKTELR--FQESDEEIQIKVNWEEEAAS-GLLT
SLKDNVPKATGALYDYVNKYHWEHTGLTLREASSKLRRNLQNNAEWVYQGAIRQIDDID-
-LRFQKAASGTTGTYQKWKDKAQNLYQELL-TQEGQTSFQGLKDKVFDGLVRVTQEFHTK
VKHLIDSLIDFLNFPRFQFPGKPGTYTGEELCTMFIREVGMVLSQVCLKVHNGSEILFSY
FQDLV----------ITLPFELRRHK---------LIDVISMCRERLK----VLSEEAQE
VFKDIQSLKT-TEVLRNLQDIL-QFIFQLIEGNIKELKEMKFTHLINYIQDEINTIFNDY
IPYVFKLLKENLCLNLHKFN----EFIQNELQGASQELQQIHQYIMALREEYFDPSVVGW
TVKYYELEEKIVRLIKNLLVALKDFHSEYIVSASDFTSQLSSQVEQFLHRNIQEYLSILT
DPDGKGKEKIAELSTTAQEIIKSQAIAMKEIISDYHQ

PF12491 // ENSGT00590000083139_0_Domain_6 (4658, 4716)

QFRYKLQDFSDQLSDYYEKFIAE
SKRLIDLSIQNYHTFLIYIMELLKKLQS-TTV--MNPYVKLAPGELTIIL----------
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-----------------------------------------------MGPRKPALR----
------TPLLL-LFLLLFLDTSVWAQDEVLENLS-FSCPKDATR

PF01347 // ENSGT00590000083139_0_Domain_0 (105, 673)

FKHLRKYVYNYEAESS
SGVQGTADSRSATKINCKVELEVPQICGFIMRTNQCTLKEVYGFNPEGKALMKKTKNSEE
FAAAMSRYEL-KLAIPEGKQIVLYPDKDEPKYILNIKRGIISALLVPPETEEDQQEL---
FLDTVYGNCSTQVTVNSRKGTVPTEMSTERN----LQQCDGFQPISTSVSPLALIKGLVH
PLSTLISSSQTC-QYTLDPKRKHVSEAVCDEQHLFLPFSYKNKYGIMTRVTQKLSLEDTP
--KINSRFFSEG-TNRMGLAFESTKSTSSPKQ-ADAVLKTLQELKKLSISEQNAQRANLF
NKLVTELRGLTGEAITSLLPQLIEVSS--PITLQALVQCGQPQCYTHILQWLKTEKAHPL
LVDIVTYLMALIPNPSTQRLQEIFNTAKEQQSRATLYALSHAVNSYFD-VDHSRSPVL-Q
DIAGYLLKQIDNECTGNEDHTFLILRVIGNMGRTMEQVMPALKSSVLSCVRSTKPSLLIQ
KAALQALRKMELEDEVRTILFDTFVNGVAPVEKRLAAYLLLMKNPSSSDINKIAQLLQWE
QSEQVKNFVASH

ENSGT00590000083139_0_Linker_0_3 (673, 709)

IANILNSEELYVQDLKVLIKNALENSQ-FPTIMDFR

PF09172 // ENSGT00590000083139_0_Domain_3 (709, 1017)

KFSRNYQISKSA
SLPMFD-PVSVKIEGNLIFDPSSYLPRESLLKTTLTVFGLASLDLFEIGLEGKGFEPTLE
ALFGKQGFFPDSVNKALYWVNGRVPDGVSKVLVDHFGYTTDGKHEQDMVNGIMPIVDKLI
KDLKSKEIPEARAYLRILGKELSFVRLQDLQVLGKLLLSGAQTLQGIPQMVV-QAIREGS
KNDLFLHYIFMDNAFELPTGAGLQLQVSSSGVFTPGIKAGVRLELA-NIQAELVAKPSVS
LEFVTNMGIIIPDFAKSSVQMNTNFFHESGLEARVALKAGQLKVIIPSPKRPVKLF

ENSGT00590000083139_0_Linker_3_5 (1017, 1044)

SGSN
TLHLVSTT----KTEVIPPLVEN

PF06448 // ENSGT00590000083139_0_Domain_5 (1044, 1156)

RQSWSTCKPLFTGMNYCTTG-AYSNASSTESASYYPL
TGDTRYELELRPTGEVEQYSATATYELLKEDKSLVDTLKFLVQAEGVQQSEATVLFKYNR
RSRTLSSEVLIPGFD

ENSGT00590000083139_0_Linker_5_6 (1156, 4658)

VNFGTILRVNDESAKDKNTYKLILDIQNKKITEVSLVGHLSYDKK
GDGKIKGVVSIPRLQAEARSEVHTHWSSTKLLFQMDSS--ATAYGSTISKRVTWRYDNEI
IEFDWNTGTNVDTKKVASNFPV----DLSHYPRMLHEYANGLLDHRVPQTDVTFRDMGSK
LIVATNTWLQMATRGLPYPQTLQDHLNSLSELNLLKMGLSDFHIPDNLFLKTDGRVKYTM
NRNKINIDIPLPLGGKSSKDLKMPESVRTPALNFKSVGFHLPSREVQVPTFTIPKTHQLQ
VPLLGVLDLSTNVYSNLYNWSASYTGGNTSR-D--HFSLQAQYRMKTDSVVDLFSYSVQG
SGETTYDSKNTFTLSCDGSLHHKF-LDSKFKVSHVEKFGNSPVSKGL---LTFETSSALG
PQMSATVHLDSKKKQHLYVKDIKVDGQFRASSFYAQGKYGLSCERDVTTGQLSGESNMRF
NSTYFQGTNQIVGMYQDGALSITSTSDLQDGIFKNTASLKYENYELTLKSDSSGQYENFA
ASNKLDVTFSTQSALLRSEHQANYKSLRLVTLLSGSLTSQGVELNADILGTDKINTGAHK
ATLKIARDGLSTSATTNLKYSPLLLENELNAELGLSGASMKLSTNGRFKEHHAKFSLDGR
AALTEVSLGSIYQAMILGADSKNIFNFKLSREGLRLSNDLMGSYAEMKLDHTHSLNIAGL
SLDFFSKMDNIYSGDKFYKQNFNLQLQPYSFITTLSNDLRYGALDLTNNGRFRLEPLKLN
VGGNFKGTYQNNELKHIYTISYTDLVVASYRADT---VAKVQGVEFSHRLNADIEGLTSS
VDVTTSYNSDPLHFNNVFHFSLAPFTLGIDTHTSGDGKLSFWGEHTGQLYSKFLLKAEPL
ALIVSHDYKGSTSHSLPYESSISTALEHTVSALLTPAEQTSTWKFKTKLNDKVYSQDFEA
YNTKDKIGVELSGR--ADLSGLYSPIKLPFFYSEPVNVLNGLEVNDAVDKPQEFTIIAVV
KYDKNQDVHTINLPFFKSLPDYLERNRRGMISLLEAMRGELQRLSVDQFVRKYRAALSRL
PQQIHHYLNASDWERQVAGAKEKITSFMENYRITDNDVLIAIDSAKINFNEKLSQLETYA
IQFDQYIKDNYDPHDLKRTIAEIIDRIIEKLKILDEQYHIRVNLAKSIHNLYLFVENVDL
NQVSSSNTSWIQNVDSNYQVRIQIQEKLQQLRTQIQNIDIQQLAAEVKRQMDAIDVTMHL
DQLRTAILFQRISDIIDRVKYFVMNLIEDFKVTEKINTFRVIVRELIEKYEVDQHIQVLM
DKSVELAHRYSLSEPLQKLSNVLQRIEIKDYYEKLVGFIDDTVEWLKALSFKNTIEELNR
LTDMLVKKLKAFDYHQFVDKTNSKIREMTQRINAEIQALKLPQKMEAL-KLLVEDFKTTV
SNSLERLKDTKVTVVIDWLQDIL-----TQMKDHFQDTLEDVRDRIYQMDIQRELEHFLS
LVNQVYSTLVTYMSDWWTLTAKNITDFAEQYSIQNWAESIKVLVEQGFIVPEMQTFLWTM
PAFEVSLRALQEGNFQTPVFIVPLTDLRIPSIRINFKMLKNIKIPLRFSTPEFTLLNTFH
VHSFTIDLLEIKAKIIRTIDQILSSELQWPLPEMYLRDLDVVNIPLARLTLPDFHVPEIT
IPEFTIPNVNLKDLHVPDLHIPEFQLPHLSHTIEIPAFGKLHSILKIQSPLFILDANANI
QNVTT-SGNKAEIVASVTAKGESQFEALNFDFQAQAQFLELNP--HPPVLKESMNFSSKH
VRMEHEGEIVFDGKAIEGKSDTVASLHTEKNEVEFNNGMTVKVNNQLTLDSHTKYFHKLS
VPRLDFSSKASLNNEIKTLLEAGHVALTSSGTGSWNWACPNFSDEGIHSSQISFTVDGPI
AFVGLSNNINGKHLRVIQKLTYESGFLNYSKFEVESKVESQHVGSSILTANGRALLKDAK
AEMTGEHNANLNGKVIGTLKNSLFFSAQPFEITASTNNEGNLKVGFPLKLTGKIDFLNNY
ALFLSPRAQQASWQASTRFNQYKYNQNFSAINNEHNIEASIGMNGDANLDFLNIPLTIPE
IN--LPYTEFKTPL-LKDFSIWEETGLKEFLKTTKQSFDLSVKAQYKKNSDKHSIVVPLG
MFYEFILNNVNSWDRKFEKVRNNALHFLTTSYNEAKIKVDKYKTENSLNQPSGTFQNHGY
TIPV---VNIEVSPFAVETLASSHVIPTAISTPSVTIPGPNIMVPSYKLVLP-PLELPVF
HGPGNLFKFFLPDFKGFNTIDNIYIPAMGNFTYDFSFKSSVITLNTNAGLYNQSDIVAHF
LSSSSFVTDALQYKLEGTSRLMRKRGLKLATAVSLT-NKFVKGSHDSTISLTKKNMEASV
RTTANLHAPIFSMNFKQELNGNTKSKPTVSSSIELNYDFNSSKLHSTATGGIDHKFSLES
L-----TSYFSIESFTKGNIKSSFLS-QEYSGSVANEANVYLNSKGTRSSVRLQGASKVD
GIWNVEVGENFAGEATLQRIYTTWEHNMKNHLQVYSYFFTKGKQTCRATLELSPWTMSTL
LQVHVSQLSSLLDLHHFDQEVILKANTKNQKISWKGGVQVESRVLQHNAQFSNDQEEIRL
DLAGSLDGQLWDLEAIFLPVYGKSLQELLQMD-----GKRQYLQASTSLLYTKNPNGYLL
SLPVQELADRFI--IPGIKLND-------------------------FSGVKIYKKLSTS
PFALNLTMLPKVKFPGIDLLTQYSTPEGSSVPIFEATIPEIHLTVSQFTLPKSLPVGNTV
FDLNKLANMIADVDLPSVTLPEQTIVIPPLEFSVPAGIFIPFFGELTARAGMASPLYNVT
WSAGWKTKADHVETFLDSMCTSTLQFLEYALKVVETHKIEEDLLTYNIKGTLQHCDFNVE
YNEDGLFKGLWDWQGEAHLDITSPALTDFHLYYKEDKT-SLSASAASSTIGTVGLDSSTD
D-QSVELNV---YFH-PQSPPEKKLSIFKTEWR--YKESDGERYIKINWEEEAAS-RLLG
SLKSNVPKASKAIYDYANKYHLEYV-------SSELRKSLQVNAEH----ARRMVDEMN-
-MSFQRVAR---DTY-------QNLYEEML-AQKSLSIPENLKKRVLDSIVHVTQKYHMA
VMWLMDSFIHFLKFNRVQFPGYAGTYTVDELYTIVMKETKKSLSQ----LFNGLGNLLSY
VQNQVEKSRLINDITFKCPFFSKPCK---------LKDLILIFREELN----ILSNIGQ-
-----QDIKF-TTILSSLQGFL-ERVLDIIEEQIKCLKDNESTCVADHINM-V---FKIQ
VPYAFKSLREDIYFVLGEFN----DFLQSILQEGSYKLQQVHQYMKALREEYFDPSMVGW
TVKYYEIEENMVELIKTLLVSFRDVYSEYSVTAADFASKMSTQVEQFVSRDIREYLSMLT
DINGKWMEKIAELSIVAKETMKSWVTAVAKIMSDYPQ

PF12491 // ENSGT00590000083139_0_Domain_6 (4658, 4714)

QFHSNLQDFSDQLSSYYEKFVGE
STRLIDLSIQNYHVFLRYITELLRKLQV-ATANNVSPYIKLAQGELMITF----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------

-----------------------------------------------MGPRKPALR----
------TPLLL-LFLLLFLDTSVWAQDEVLENLS-FSCPKDATR

PF01347 // ENSGT00590000083139_0_Domain_0 (105, 673)

FKHLRKYVYNYEAESS
SGVRGTADSRSATKINCKVELEVPQICGFIMRTNQCTLKEVYGFNPEGKALMKKTKNSEE
FAAAMSRYEL-KLAIPEGKQIVLYPDKDEPKYILNIKRGIISALLVPPETEEDQQEL---
FLDTVYGNCSTQVTVNSRKGTVPTEMSTERN----LQQCDGFQPISTSVSPLALIKGLVH
PLSTLISSSQTC-QYTLDPKRKHVSEAVCDEQHLFLPFSYKNKYGIMTRVTQKLSLEDTP
--KINSRFFSEG-TNRMGLAFESTKSTSSPKQ-ADAVLKTLQELNKLSISEQNAQRANLF
NKLVTDLRGLAGEAITSLLPQLIEVSS--PITLQALVQCGQPQCYTHILQWLKTEKAHPL
LVDIVTYLMALIPNPSTQRLQEIFNTAKEQQSRATLYALSHAVNSYFD-VDHSRRPVL-Q
DIAGYLLKQIDNECTGNEDHTFLILRVIGNMGRTMEQVMPALKSSVLSCVRSTKPSLLIQ
KAALQALRKMELEDEVRTILFDTFVNGVAPVEKRLAAYLLLMKNPSSSDINKIVQLLQWE
QSDQVKNFVASH

ENSGT00590000083139_0_Linker_0_3 (673, 709)

IANILNSEELYVQDLKVLIKNALENSQ-FPTIMDFR

PF09172 // ENSGT00590000083139_0_Domain_3 (709, 1017)

KFSRNYQISKSA
SLPMFD-PVSVKIEGNLIFDPSSYLPRESLLKTTLTVFGLASLDLFEIGLEGKGFEPTLE
ALFGKQGFFPDSVNKALYWVNGQVPDGVSKVLVDHFGYTTDGKHEQDMVNGIMPIVDKLI
KDLKSKEIPEARAYLHILGKELSFVRLQDLQVLGKLLLSGAQTLQGIPQMVV-QAIREGS
KNDLFLHYIFMDNAFELPTGAGLQLQVSSSGVFTPGIKAGVRLELA-NIQAELVAKPSVS
LEFVTNMGIIIPDFAKSSVQMNTNFFHESGLEARVALKAGQLKVIIPSPKRPVKLF

ENSGT00590000083139_0_Linker_3_5 (1017, 1044)

SGSN
TLHLVSTT----KTEVIPPLVEN

PF06448 // ENSGT00590000083139_0_Domain_5 (1044, 1156)

RQSWSTCKPFFTGMNYCTTG-AYSNASSTESASYYPL
TGDTRYELELRPTGEVEQYSATATYELLKEDKSLVDTLKFLVQAEGVQQSEATALFKYNR
RSRTLSSEVLIPGFD

ENSGT00590000083139_0_Linker_5_6 (1156, 4658)

VNFGTILRVNDESAKDKNTYKLILDIQNKKITEVSLVGHLSYDKK
GDGKIKGVVSIPRFQAEARSEVHTHWSSTKLLFQMDSS--ATAYGSTISKRVTWRYDNEI
IEFVWNTGTNVDTKKVASNFPV----DLSHYPRMLHEYANGLLDHRVPQTDVTFRDMGSK
LIVATNTWLQMATRGLPYPQTLQDHLNSLSELNLLKMGLSDFHIPDNLFLKTDGRVKYTM
NKNKINIDIPLPLGGKSSKDLKMPESVRTPALNFKSVGFYLPSREVQVPTFTIPKTHQLQ
VPLLGVLDLSTNVYSNLYNWSASYTGGNTSR-D--HFSLQAQYRMKTDSVVDLFSYSVQG
SGETTYDSKNTFTLSCDGSLHHKF-LDSKFKVSHVEKFGNSPVSKGL---LTFETSSALG
PQMSATVHLDSKKKQHLYVKDIKVDGQFRASSFYAQGKYGLSCERDVTTGQLSGESNMRF
NSTYFQGTNQIVGMYQDGALSITSTSDLQDGIFKNTASLKYENYELTLKSDSSGQYENFA
ASNKLDVTFSTQSALLRSEHQANYKSLRLVTLLSGSLTSQGVELNADILGTDKINTGAHK
ATLKIARDGLSTSATTNLKYSPLLLENELNAELGLSGASMKLSTNGRFKEHNAKFSLDGR
AALTEVSLGSIYQAMILGADSKNIFNFKLSREGLRLSNDLMGSYAEMKLDHTHSLNIAGL
SLDFFSKMDNIYSGDKFYTQNFNLQLQPYSFITTLSNDLRYGALDLTNNGRFRLEPLKLN
VGGNFKGTYQNNELKHIYTISYTDLVVASYRADT---VAKVQGVEFSHRLNADIEGLTSS
VDVTTSYNSDPLHFNNVFHFSLAPFTLGIDTHTSGDGKLSFWGEHTGQLYSKFLLKAEPL
ALIVSHDYKGSTSHSLPYESSISTALEHTVSALLTPAEQTSTWKFKTKLNDKVYSQDFEA
YNTKDKIGVELSGR--ADLSGLYSPLKLPFFYSEPVNVLNGLEVNDAVDKPQEFTIIAMV
KYDKNQDVHTINLPFFKSLPDYLERNRRGMISLLEAMRGELQRLSVDQFVRKYRAALSRL
PQQIHHYLNASDWERQVAGAKEKITSFMENYRITDNDVLIAIDSAKINFNEKLSQLETYA
IQFDQYIKDNYDPHDLKRTIAEIIDRIIEKLKILDEQYHIRVNLAKSIHNLYLFVENVDL
NQISSSNTSWIQNVDSKYQIRIQIQEKLQQLRTQIQNIDIQQLAAEVKQQMDAIDVTMHL
DQLRTAILFQRISDIIDRVKYFVMNLIEDFKVTEKINTFRVIVRELIEKYEVDKHIQVLM
DKSVELAHRYSLSEPLQKLSNVLQQIEIKDYYEKLVGFIDDTVEWLKALSFKNTIEELNR
LTDMLVKKLKAFDYHQFVEKTNSKIREMTQRINAEIQALKLPQKLEAL-KLLVEDFKTTV
SNSLERLKDTKVTVVIDWLQDIL-----TQMKDHFQDTLEDVRDRIYQMDIQRELEHFLS
LVNQVYSTLVTYMSDWWTLTAKNITDFAEQYSIQNWAESIKVLVEQGFIVPEMQTFLWTM
PAFEVSLRALQEGNFQTPVFIVPLTDLRIPSIRINFKMLKNIKIPLRFSTPEFTLLNTFH
VHSFTIDLLEIKAKIIRTIDQILSSELQWPLPEMYLRDLDVVNIPLARLTLPDFHVPEIT
IPEFTIPNVNLKDLHVPDLHIPEFQLPHLSHTIEIPAFGKLHSILKIQSPLFILDANANI
QNVTT-SGNKAEIVASVTAKGESQFEALNFDFQAQAQFLELNP--HPPVLKESMNFSSKH
VRLEHEGEIVFDEKAIEGKSDTVASLHTEKNEVEFNNGMTVKVNNQLTLDSHTKYFHKLS
VPRLDFSSKASLNNEIKTLLEAGHVALTSSGTGSWNWVCPNFSDEGIHSSQISFTVDGPI
AFVGLSNNINGKHLRVIQKLTYESGFLNYSKFEVESKVESQHVGSSILTANGQALLKDAK
AEMTGEHNANLNGKVIGTLKNSLFFSAQPFEITASTNNEGNLKVGFPLKLTGKIDFLNNY
ALFLSPRAQQASWQASTRFNQYKYNQNFSAINNEHNIEASIGMNGDANLDFLNIPLTIPE
IN--LPYTEFKTPL-LKDFSIWEETGLKEFLKTTKQSFDLSVKAQYKKNSDKHSIVVPLG
MFYEFILNNVNSWDRKFEKVRNNALHFLTTSYNEAKIKVDKYKTENSRNQPSGTFQNHGY
TIPV---VNIEVSPFAVETLASSHVIPKAISTPSVTIPGPNIMVPSYKLVLP-PLELPVF
HGPGNLFKFFLPDFKGFNTIDNIYIPAMGNFTYDFSFKSSVITLNTNAGLYNQSDIVVHF
LSSSSFVTDALQYKLEGTSRLMRKRGLKLATAVSLT-NKFVKGSHDSTISLTKKNMEASV
RTTANLHAPIFSMNFKQELNGNTKSKPTVSSSIELNYDFNSSKLHSTAKGGIDHKFSLES
L-----TSYFSIESFTKGNIKGSFLS-QEYSGSVANEANVYLNSKGTRSSVRLQGASKVD
GIWNVEVGENFAGEATLQRIYTTWEHNMKNHLQVYSYFFTKGKQTCRATLELSPWTMSTL
LQVHVSQLSSLLDLHHFDQEVILKANTKNQKISWKGGVQVESRVLQHNAQFSNDQEEIRL
DLAGSLDGQLWDLEAIFLPVYGKSLQELLQMD-----GKRQYLQASTSLLYTKNPNGYLL
SLPVQELADRFI--IPGIKLND-------------------------FSGVKIYKKLSTS
PFALNLTMLPKVKFPGIDLLTQYSTPEGSSVPIFEATIPEIHLTVSQFTLPKSLPVGNTV
FDLNKLANMIADVDLPSVTLPEQTIVIPPLEFSVPAGIFIPFFGELTAHAGMASPLYNVT
WSAGWKTKADHVETFLDSMCTSTLQFLEYALKVVETHKIEEDLLTYNIKGTLQHCDFNVE
YNEDGLFKGLWDWQGEAHLDITSPALTDFHLYYKEDKT-SLSASAASSTIGTVGLDSSTD
D-QSVRLNV---YFH-PQSPPEKKLSIFKTEWR--YKESDGERYIKINWEEETAS-RLLG
SLKSNVPKASKAIYDYANKYHLEYV-------SSELRKSLQVNAEH----ARRMVDEMN-
-MSFQRVAR---DTY-------QNLYEEML-AQKSLSIPENLKKRVLDSIVHVTQKYHMA
VMWLMDSFIHFLKFNRVQFPGYAGTYTVDELYTIVMRETKKSLSQ----LLNGLENLLSY
VQNQVEKSRLINDITFKCPFFPKPCK---------LKDLILIFREELN----ILSNIGQ-
-----QDIKF-TTILSSLQGFW-ERVLDIIEEQIKCLKDNESTCVADHINM-V---FKVQ
VPYAFKSLREDIYFVLGEFN----DFLQSILQEGSYKLQQVHQYMKALREEYFDPSMVGW
TVKYYEIEENMVGLIKTLLVSFRDVYSEYSVTAADFASKMSTQVEQFVSRDIREYLSMLT
DINGKWMEKIAELSIVAKETMKSWVTAVAKIMSDYPQ

PF12491 // ENSGT00590000083139_0_Domain_6 (4658, 4714)

QFHSNLQDFSDQLSRYYEKFVGE
STRLIDLSIQNYHVFLRYITELLRKLQV-VTANNVSPYIKFAQGELMITF----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------

-----------------------------------------------MGPRKPALR----
------TPLLL-LFLLLFLDTSVWAQDEVLENLS-FSCPKDATRFK

PF01347 // ENSGT00590000083139_0_Domain_0 (107, 673)

YLRKYVYNYEAESS
SGVPGTADSRSATKINCKVELEVPQTCGLIMRTNQCTLKEVYGFNPEGKALMKKTKNSEE
FAAAMSRYEL-KLAIPEGKQIVLYPDKDEPKYILNIKRGIISALLAPPETEEDQQEL---
FLDTVYGNCSTQVTVNSRKGTVPTEMSTERN----LQQCDGFQPISTSVSPLALIKGLVH
PLSTLISSSQSC-QYTLDPKRKHVSEAVCDEQHLFLPFSYKNKYGIMTRVTQKLSLEDTP
--KTNSRFFSEG-THRMGLAFESTKSTSSPKQ-AEAVLKTLQELKKLSISEQNAQRANLF
NKLVTELRGLTGEAITSLLPQLTAVSS--PITLQALVQCGQPQCYTHILQWLKTEKAHPL
LIDIVTYLMALIPNPSTQRLQEIFNTAKEQQSRATLYALSHAVNSYFD-VDHSRSPVL-Q
DIAGYLLKQIDNECTGNEDHTFLILRVIGNMGRTMEQVMPALKSSVLNCVRSTKPSLLIQ
KAAIQALRKMELEDEVRTILFDTFVNGVAPVEKRLAAYLLLMKSPSSSDINKIAQLLQWE
QSEQVKNFVASH

ENSGT00590000083139_0_Linker_0_3 (673, 709)

IANILNSEELYVQDLKILIKNALENSQ-FPTIMDFK

PF09172 // ENSGT00590000083139_0_Domain_3 (709, 1017)

KFSRNYQISKSA
SLPMFD-PVSVKIEGNLIFDPSSYLPKESLLKTTLTVFGLASLDLFEIGLEGKGFEPTLE
ALFGKQGFFPDSVNKALYWVNGRVPDGVSKVLVDHFGYTTDDKHEQDMVNGIMPIVDKLI
KDLKSKEIPEARAYLRILGKELSFVRLQDLQVLGKLLLSGAQTLQGIPQMVV-QAIREGS
KNDLFLHYIFMENAFELPTGAGLQLQVSSSGVFTPGIKAGVRLELA-NIQAELVAKPSVS
LEFVTNMGIIIPDFAKSSVQMNTNFFHESGLEARVALKAGQLKVIIPSPKRPVKLF

ENSGT00590000083139_0_Linker_3_5 (1017, 1044)

SGSN
TLHLVSTT----KTEVIPPLIEN

PF06448 // ENSGT00590000083139_0_Domain_5 (1044, 1156)

RQSWSTCKPFFTGMNYCTTG-AYSNASSTESASYYPL
TGDTRYELELRPTGEVEQYSATATYELLKEDKSLVDTLKFLVQAEGVQQSEATALFKYNR
RSRTLSSEVLIPGFD

ENSGT00590000083139_0_Linker_5_6 (1156, 4658)

VNFGTILRVNDESAKDKNTYKLILDIQNKKITEISLVGHVSYDKK
GDGKIKGVVSIPRLQAEARSEVHTHWSSAKLLFRMDSS--ATAYGSTISKRVTWRYDNEI
IEFDWNTGTNVDTKKVASNFPV----DLSHYPRMLHEYANGLLDHRVPQTDVTFRDMGSK
LIVVTNTWLQMATRGLPYPQTLQDHLNSLSELNLLKMGLSDFHIPDNLFLKTDGRVKYTM
NKNKINIDIPLPLGGKSSKDLKMPESVRTPALSFNFVGFHLPSREVQVPTFTIPKTHQLQ
VPLLGVLDLSTNVYSNLYNWSASYTGGNTSR-D--HFSLQAQYRMKTDSVVDLFSYSVQG
SAETTYDSKNTFTLSCDGSLHHKF-LDSKFKVSHVEKFGNSPVSKGL---LTFETSSALG
PQMSATVHLDSKKKQHLYVKDIKVDGQFRASSFYAQGKYGLSCERDVTTGQLSGESNMRF
NSTYFQGTNQIVGMYQDGTLSITSTSDLQDGIFKNTASLKYENYELTLKSDSSGQYENFA
ASNKLDVTFSTQSALLRSEHQANYKSLRLVTLLSGSLTSQGVELNADILGTDKINTGAHK
ATLKIARDGLSTSVTTNLKYSPLLLENELNAELGLSGASMKLSTNGRFKEHHAKFSLDGR
AALSEVSLGSIYQAMILGADSKNIFNFKLSREGLRLSNDLMGSYAEMKLDHTHSLNIAGL
SLDLFSKMDNIYSGDKFYKQNFNLQLQPYSFITTLSNDLRYGALDLTNNGRLRLEPLKLN
VGGNFKGTYQNNELKHIYTISYTDLVVASYRADT---VAKVQGVEFSHRLNADIEGLTSS
VDVTTSYNSDPLHFNNVFHFALAPFTLGIDTHTSGDGKLSFWGEHTGQLYSKFLLKAEPL
ALTVSHDYKGSTSHNLPYKSSISTALEHTVSALLTPAEQTSTWKFKTKLNDKVYSQNFEA
YNTKDKIGVELSGR--ADLSGLYSPIKLPFFYSEPVNVLNGLEVNDAVDKPQEFTIIAMV
KYDKNQDVHTINLPFFKSLPDYLERNRRGMISLLEAMRGELQRLSVDQYVRKYRAALSRL
PQQIHDYLNASDWERQVASAKEKITSFMENYRITDNDILSAIDSAKINFNEKLSQLETYA
IQFDQYIKHNYDPHDLKRTIAEIIDRIIEKLIILDEQYHIRVNLAKSIHNLYLFVENVDL
NQISSSNTSWIQNVDTKYQVRIQIQEKLQQLRTQIQNIDIQQLAAEVKQQIDAIDVTMHL
DQLRTAILFQRISDIIDRVKYFVMNLIEDFKVTEKINIFRVIVRELIEKYEVDQHIQVLM
DKSVELAHRYSLREPLQKLSNVVQQIEIKDYCEKLVGFIDDTVEWLKALSFKNTIEELNR
LTDMLVKKLKAFDYHQFVDKTNSKIHEMTQRINAEIQALELPQKMEAL-KLLVEDFKTTV
SNSLERLKDTKITVVIDWLQDIL-----TQMKDYFQDTLEDVRDRIYQMDIQWELEHFLS
LVNQVYSTLVTYMSDWWTLTAKNITDFAEQYSIQNWAESIKVLVEQGFIVPEMQTFLWTM
PAFEVSLRALQEGNFQTPDFIVPLTDLRIPSIRINFKMLKNIKIPLRFSTPEFTLLNTFH
VHSFTIDLLEIKAKIIRTIDQILSSELQWPLPEIYLRDLDVLNIPLARLTLPDFHVPEIT
IPEFTIPNVNLKDLHVPDLHIPEFQLPRLSHTIEIPAFGKLHSILKIQSPLFILDANANI
QNVTT-SENKAEIVASVTAKGESQFEALNFDFQAQAQFLELNP--HPPVLKESMNFSSKH
VRMEHEGEIVFDGKAIEGKSDTVASFHTEKNEVEFNNGMTVKVNNQLTLDSHTKYFHKLS
VPRLDFSSKASLNNEIKTLLEAGHVTLTSSETGSWNWACPNFSDEGIHSSQISFTVDGPI
AFFGLSNNINGKHLRVIQKLTYESGFLNYSKFEVESKVESQHVGASILTANGQALLKDAK
AEMTGEHNANLNGKVIGTLKNSLFFSAQPFEITASTNNEGNLKVSFPLKLTGKIDFLNNY
ALFLSPHAQQASWQASTRFNQYKYNQNFSAINNEHNIEASIGMNGDANLDFLNIPLTIPE
IN--LPYTEFKTPL-LKDFSIWEETGLKEFLKTTKQSFDLSVKAQYKKNSDKHSIVVPLS
MFYEFILNNVNSWDRKFEKVRNNALHFLTTSYNEAKIKVDKYKTENSLNQPSGTFQNHGY
TIPV---VNIEVSPFAIETLTSSHVISKAISTPSVTIPGPNIMVPSYKLVLP-PLELPVF
HGPGNLFKFFLPDFKGLSTIDNIYIPAMGNFTYDFSFKSSVITLNTNAGLYNQSDIVAHF
LSSSSFVTDALQYKLEGTSRLMRKRGLKLATAVSLT-NKFVKGSHDSTISLTKKNMEASV
RTTANLHAPIFTMNFKQELNGNTKSKPTVSSSIELNYDFNSSKLHSTAKGGIDHKFSLES
L-----TSYFSIESFTKGNIKGSFLS-QEYSGSVANEANVYLNSKGTRSSVRLQGASKVD
GIWNFEVGENFAGEATLRRIYATWEHNMKNHLQVYGYFFTKGKQTCRATLELSPWTMSTL
LQVHVSQLSSLLDLHHFDQEVILKANTKNQKVSWKGGVQVESRVLQHNAQFSNDQEEIQL
DLAGSLDGQLWDLETIFLPVYGKSLQELLQMD-----GKRQYLQASTSLRYTKNPNGYLL
SLPVQELADRFI--IPGIKLND-------------------------FSGIKIYKKLSTS
PFALNLTMLPKVKFPGIDLLTQYSTPEGSSVPIFEATIPEIHLTVSQFTLPKSLPVGNTV
FDLNKLANMIADVDLPSVTLPEQAIVIPPLEFSVPAGIFIPFFGELTARVGMASPLYNVT
WSAGWKTKADHVETFLDSMCTSTLQFLEYALKVVETHKIEEDMLTYNIKGTLQHCDFNVE
YNEDGLFKGLWDWQGEAHLDITSPALTDFHLYYKEDKT-SLSASAASSTIGTVGLDSSTD
D-QSVKLNV---YFH-PQSPPDKKLSIFKTEWR--YKESDGERYIKINWEEEAAS-RLLG
SLKSNVPKASKAIYDYANKYHLEYF-------SSELRESLQVNAEH----ARRMVDEMN-
-MSAQRVAR---DTY-------QNLYEEML-TQKNLRIPENLKKRVLDSIVHVTQKYHMA
VMWLMDSFIHFLKFNRVQFPGYIGTYTVDELYTIVMRETKKSLSQ----LFNGLGNLLSY
VQNQVEKSRLINDITFKCPFSPKPCK---------LKDLILIFREELN----ILSNIGQ-
-----QDIKF-TTILSSLQGFL-ERVLDIIEEQIKCLKDNESTCVADHINM-V---FKIQ
VPYAFKSLREDIYSVLSEFN----DFLQSILQEGSYKLQQVHQYMKALREEYFDPSMVGW
TVKYYEIEENMVDLIKTLLVSFRDVYSEYSVTAADFASKMSTQVEQFVSRDIREYLSMLA
DINGKWMEKIAELSIVAKEAMKSWVTAVAKIMSDYPQ

PF12491 // ENSGT00590000083139_0_Domain_6 (4658, 4714)

QFHSNLQDFSDQLSSYYEKFVGE
STRLIDLSIQNYHVFLRYITELLRKLQV-ATANNVGPYIKFAQGELMITF----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------PQL

PF01347 // ENSGT00590000083139_0_Domain_0 (147, 673)

CSFVLRASQCTLEELRDFSPDGEALLKKTKNSEE
FAAAMSRYEL-RLAISEGKQVVLYPEKDEPKHILNIKRGIISALLAPPEIEEDQQVL---
FLDTVYGNCSTDVTVQTRQGDVATAVSTERK----LQQCDGFQPVGAGASPLALIKGLVR
PLSTLISSNQSC-QYTLDPKRKHVSEATCQEQHLFLPFSYMNKYGMMAHVTQKVKLEDTP
--MINSRFFEGG-AEPVGLAFESTKSTSLPKQ-AEAVLKTLQELTKLSVSEQNIKRATLF
NELVMELRGLSDEAVSALLPQLVELSS--PITLQALVQCGQPQCYTHILQWLRNEKAHPL
LIDIVTYLVALIPEPSAQRLQEVFNTAKEQQSRVTLYALSHVVNNYHK-INQAVTQGL-Q
DITDYLLEQIRNECTGDEEHTYLILRVIGNMGSTMEQVMPRLKSSILKCIRSTKPSLLIQ
KAAIQALRKMKLEDEVRGILLQTFVNSTAPVEKRLAAYLMLMRQPSSSDIHKITQLLPRE
LNEQVKNFVASH

ENSGT00590000083139_0_Linker_0_3 (673, 709)

IANILNSEELHIDSLKNLVTEALKESQ-LPTVMDFR

PF09172 // ENSGT00590000083139_0_Domain_3 (709, 1017)

RFSQNYHFSKSV
SLPSLD-PVSAKIEGNLIFDPNNYLPKESMLKTTLTAFGCASTDLFEIGLEGKGFEPTLE
ALFGKQGFFPDSVNKALYWVNGQVPDHVSKVLMDHFGYTKDDKHEQDMVKGIMPMVDKLI
NELKSREIPEARAYLRLLGEELGFVRLQDFQLLGRLLLNGARTLQGIPQMIG-KAMREGS
KNDLFLHYIFMDNAFELPTGMGLPLQVSSSGVVTPGTKAEVKLELA-QMQAELVAKPSVS
VEFVTHMGITIPDFARSGIQMNTNLFHESGLEVRMALKAGQLKFIIPSPPRPIKLF

ENSGT00590000083139_0_Linker_3_5 (1017, 1044)

SSSN
TLHLVSTT----KMEAIPPLTED

PF06448 // ENSGT00590000083139_0_Domain_5 (1044, 1156)

RQTWSTCKPLFPGLNYCTTG-AFSTDSSTESASFYPL
TGDTRYELELQPSGEVKQYAASATYELQTQAKALVDTLKFVIQAEGVKQTEAMMLFKYNR
RSRTLSSEIQIPDFD

ENSGT00590000083139_0_Linker_5_6 (1156, 4658)

IDFGTILRVNDESDEDKKSYKLTLDIQNKKLTEAALTGYVSYDTK
GEGKIKGVISIPRLQAEARSEVHTHWSPTKLLLRMDSS--ATAYGSTVSKKVAWRYDGEK
IEFDWNTGTNMDTKKVSSHFPV----DLSDYPRSLHHYVNSLLDHRIPETDMTFRHMGST
LIVATSTWLQMASRTLPYAQTLQDHLNGLTELNFQKMGLPDFHIPDNLFLKSDGRVKYTF
NQNTVKLEIPLPLGGKSSKDLKMPETIRIPAINFKFVGIHLPSQQFQVPTFTIPELYQLQ
VPLLGVLDLSTNVYSNLYNWSASYTGGNTSR-E--HFSLKAQYHIKADSVVDLLSYSVQG
SGETTYDYRNTFTLSSDGSLHHKF-LDSNVKFSHVEKLGINPASKGL---LTFDASSSWD
STMSASVHWDSKKKQHLYVKDVKADGQFTASSFYAKGTHGLTFQMDSTTGQLSGESNIRF
NSSYLQGTNQIKGQYQDGTLSLASTSDLQDGIFKNTASLKYENYALTLKSDSNGKYENFA
TSNKLDLTFSKQKASLRSEYQADYKSLTFLTQLSGSLDSRGFELNADITGNDKTNSGAHK
ATLKISQDGLSTSATTNLKYSPLLLENEMNADLRLSGASMKLTTNGRFREHYAKFSLDGK
AALTEVSLGSVYQAMILGMDSNNVFNFRISQEGLKLSNDMKGSYAEMKLDHTNSLNIAGL
SLDFSSKMDNIYSSDKFYKQNFNLHLQPLILVTTFNNDLKYNALDWNSNGKLRLEPLKLN
VGGNLKGTYQNNEIKHIYALSYADLS-ASYQADT---VARVQGAEFSHRFNTDIAGLASS
VDISTTYNSDSLHFSNIVHSAIAPFTLATDVHTNANGILSLWGEHTGQLYSKFLLKAEPL
ALTFAHDYKGSTTHHFRSRKIISTAFDHKVSALLTPAEQMSSWKFKTQFNDNQYSQDFEA
YNTKEKIGVEFTGQALTDVSMLNSPIKVPFLLSEPVNVLNSLEMKDAADKPQEFTIVAFI
KYDKNQDVHTISLPFLNILPDYVERNRKVIIAVLESIQKELKSIDTDQVVRKYRASLGSF
SQQVNDYLNDFNWDRQVSSAKETLTTFTENYGITENDLQVALDNAKININEKLSDLQTYM
IQFDQYIRDNYDLHDFKIAIAKIIDRILEKVKILDEHYHIRVNLAKTIHDLHLFIENIDF
NKIGGSTASWVQNVDTKYQIRIQIQEKLQQLRIQIQDTDIQQFSAKLNQQIEAANIRMLL
DQLRSIIEFQRINDFIEHVKYLVMNFIDTLEVTDKINSFRAILHEFIKKYELELQIQILG
DKLVHLAHQYKLKETVQKLSNALLQVEIKDYYEKLGGFIDDAVKQLKALSFKKFIEEVNR
LLDLLVKKLKAFDYHQFVDGTNNIIREVTQRINSEIQGLDLQRKAEAL-KQFIGDIKDLV
-------SDAKVSMLIDWFLDAVN-----LVKDYFQYPLEDVRDRLYQLNIQWEIERYLS
LVSQVYNTLVTYISDWWVLAAKNLTDFAQQYSIQDWAEKVNALVEQGFIIPEIQTALGTM
PAFEVSLRALQNATFLTPDFIVPLTDLRIPSIKINFKELKDIKIPSRFSTPEFTIFNTFH
IPSFTIDLEEIKAKVIRTIDQMMDGEMRWPVPDIYLKDLMMGDLPLTGFTLPDFHFPEIK
VPELVIPNLNPKDFQVADLHIPEFQLPHISDTITIPAFGKLSSILKIQSPFFTLDANADI
QNVTI-SENKAEITASITAKGQSKLEVLNFDFQANAQLLEPKI--HPLALKESVNFSSKY
LRMEHESKMLFYGNSIEGKSDTTASLHTEKNTLEFNNNVILKVNHQFALDSHTKYFHKLN
IPQFDFSSKAELLNEMKTLMEAGDLSWTSSGSGSWKWSCPNFSDEGTHESQSSLTVKRPI
ASFGFFNKINSKHLSVNQNLTFESSLFDYFNLEVKSDVESQHVGHSVLTARGTALRREMI
AEITGDHNAHLNGKVIGTLKNSLFFSAQPFQMTASTNNEGNLKVSFPLKLTGKIDFLNNY
ALFLSPDAQQTSWQASARFNQYKYNQNFSATNNENSIEAHVGINGDANLDFLNIPLTIPE
VN--LPYTLLTTPP-LKDFSIWEQTGLKKFLKTTKQSFDLSINAQYKKNKDKHSIAIPLG
LFYEFINHSINSMNWHFEKVRDDALHVLTTSYNEAKVKLDRYEAEN-LNKPPRTFQIPGY
TIPV---ANMEVSPFTVETLASSPVIPKAISTPSFSILGSSFSVPSYTLDLQ-SLELPIL
HVPRNLLQLSLPDFKELSTINNILVPALGNITYDFSFKSSFMTLNTNAVLYNQSDIVAHF
LSSSWFVMDALQYKLEGTSSLTRKRGLKLATALSLS-NKYVEGSHDSTISLTKKSMEASV
TTTAKAHFPTLRMNFKQELNGNTKSKPTISSSIELKYDFSSSKLDSTAKGALDHKLSLES
L-----TSYLAIESSTKGDVKGSILS-REYSGSVASEANTYLNSKGSRASVKLQGTSKVD
GIGNLEVKENFSGEVTLRHIYAIWEHNTKNHVQLKSLFFTSGEHTSKATLELSPWTMSAL
VQLRSSQPSSLLDNAYFGQEVALNANTKIQKVSWKSEVQVHTGSLRNNVEFSNDQEEARL
DLAGSLEGNLGYLKNIILPVYDKSLPDLLKLDLTTKTGKKQYLHASTSLVYTKNCNGHLF
SIPVQQLADKFI--IPGLKLNYLSSDL----------------------------KLSTS
PFALNLPMLPKVNFPQVDVITKYSESDDSSTPYFEITMPEAQLTVSQFTLP----VGSAA
LDVNEVANKIADFELPTITIPEQTIEIPSLKFSVPTGIFVPFFGTLTASFGVTSPLYNAT
WSAGLKNKADHIETFLDSTCSSTLQFLEYDLNVIGTHSLEDYTFISKTKGTFAHRDFSAE
YYEDIKYEGLRTAQEEIRLDISSPAFTDLHLNYQGNER-RFFFSVASPAIGSVGLDMWVV
ND-TVMGDV---YFH-PQSSPDKKLNILKTEWI--HQKSDNESEIKFNWEEEAIS-ILLS
SLKDNVPKATEAFYDYVNKYHQEYTGLSLEDTSTRLRRSIQNNAKWAYQGTMELG-----
-MGFQT------------ADKAQNLYQEML-AEDGQSTFHRCKDKIFDSIIQVTRHYNMA
VKHLTDSFIHFSKL-SFQLPGQNVTYTSDELCTMVIRKAGKILSQA-------LEKLLSY
AQNLVEKSDLIKDLKIKCPFYSRSYK---------LIDIIAESRELLD----TISESVQD
I-----SFKF-TEFLREFQNVL-QGFLQGTEEGIKNLREITLTNLLND----SSITFKEY
ILYGFRFLKQNLYLDFTEFN----EFVQSNLQQASDKLQLLHQHIKALCEAYFDPSIIGQ
SVKYHELEEKFVHLVKYIAELLADFHYTYTATVTHFASQFSIQVEEFMLRETQEYLNILT
DVDGKGKEKIEELYNTAQEIIQSWFLAIKEIISDYHQ

PF12491 // ENSGT00590000083139_0_Domain_6 (4658, 4713)

QLRSKLQEFSDQLSDYHEKFIAE
SKRLIDLSIQSYSIVLSYLIELLEKLQS-ATVSGISPYVSLVPGGLTITY----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

PF06448 // ENSGT00590000083139_0_Domain_5 (1050, 1157)

CKPFISGLNFCTKL-LYSNASSMEAAPYYPL
TGETRFEVEIVSTGEVKEYSASANYDLQREGNDLVDTLKFAVQAEGVKQHEATLTFKYNR
DRKILTSDVSIPDFDVDFGTKFRITDESVSEKKAYSFVIDFNNKKISEVTLTGQIRYAGM
EEAMLRGTVSIPRLQTELRTEALVNYSPTKGYLQMSSA--VETHGNTISKRVLLRYDSET
AELEWNSGATAAVGRMSSGFQV----DFSDYSKTLEKYANELLDRKVALTDMTMRHIVSQ
FIVATNTWLQKSSKDVPYAQTLQAKLSGLQELNIQKIKLPVITVPEELFLKSEGRIKYSF
NKNSFLINIPLPFGGRSSHEIRVPQTVKTPRLVIESMGINIPSQEYRMPAFTVPESYPLL
VPLFGALEVSASVHSNYYNWTAAYTLTNSSTEK--TSRIGTTYTVNADSIFELLSYNMKG
SGEASYS-RNGFTCAYENHLKHRL-LTSDFKMSRTKSYEPTSVSNCT---VFLMASSALG
PQLSFSSDIVSEKTNNMNINNVKIEGQLEVASVFARSIYTMSSSYNEKRRVLEGKSNLRL
DSSYLQATNHLSGRYTDGVFSITSASDVQNGLLKNTASLKYENSQLKITSETNGRYLHLA
AVNKLEFLLSKKMAALRSEYQATYKQIQYYALFAGSLSSQDLVFNTDFSLTDQRNRAAHK
SSLNINQYGLASSATTNVQFSPLTMQSEMNAKLDTSGGSMSLSSSGRYGKNNAKFNLGGR
VSLTEVTLGSEYQSTVLGMDNKHVLNFRINREGLKFSNNLQGSFKEIKLEYTNDLNIPGL
SLTFVSKLDNSFSFDKFHKHVFDLQLQPRSLTAKLNNNIKYTKTEVSNKAELLLEPLKLN
LGGNMRAAYGTDEVRHTYTITYADLT-ANFKTDT---VANVQGAAVSHRVNLNVAGLASS
ITMNTNCDSKSLRFSNALRSTMAPFTITADVHTNGNGKLIALGEHTGDLYSKMLFKAEPL
AFTFSHDYRGSTSHSFKSMRRYATQLDNKFHMLFTPSEQSSAWKLKSQLNNNMYSQDINA
YNDAEKIGVELSGRALADLSVMDTAIQLPFT-SEEVNVIDVLGLRDSMSEPQEFSISGSV
KYDKNKDMHVINLPFLEHLPVYFEQIRGAILSMLQAVQNYLKNIDIDQYMNKYKATLDEF
PQNLNDYMDKLDLKGRVSTIKTNLIAFTKDYKITSDDLEIVLEKALDNLQEVLLQFQVYL
VQIEQYIKENYDQFDINALIAQLLDKIVEKMTALDEKYKIRTTVVDTIQKLQFFFNQYYP
SNIGSSTMAWIKNVDDEYRITSRIQENLEQLKIQIQNIDIRSFAENLKRKIKVIDVKQVL
EKLKRSLPIKKMKEVLQQIKDFILSWMEEYEVPEKISAFRGHMHKLIVKYELDKHMYFLL
DRMIELLNQYRIKETVRKMMTYLRKIDVKTCFDKIVAFIDDGVKKVQTFDYEMMIKKLNK
FLDMIIKKLKSFDYNQFVDDTNNKIQEMTQKINEELRNLELPQKAEAL-KQYIRDFSTVV
SKYIEQIRDTKLVAIINWLKELIDSTTFINLKAKVNEHLEDLRERISDMDISKEFEWYLQ
KISQFYNSVVIYISEQWNIAFKKIVTLAEKYDLKNWAENLNQFIETGFKVPEIRTVIVTI
PAFEFSLRSLREATFQTPDFIVPLTDLKIPSYEINIKRLKDIKIPAKFTTPEFTVLNTFK
VPSYTIDLNEIKFQIVRMIDKLMSGEFQLPAIDLYFKDLKMRDMPFSEISFPELQMPQLE
IPELLIPKLNLNEFQIPDLKIPDFQLPRIPHTVTAPTFGKLSGAFTVASPFFTLSTQAEV
HNTTT-SANSPEFVTSLSAQATSKLDFLVFSVIADSHILAPEM--KQLKLKNSMKVSHKF
LKVDHTNEVVFLGTSVSGEAETRAKFSATKNSIELQNNLMVNLQRKIQMQSGTAYSHRLN
IPQADFSSQADLVNNMTTEIEAGRISFTSNGKGNWKWTSPNFSDEGTHNSHATFRVDGPI
LIFFADYRINDRYLKVSQSMRYECGFLSYATLQVQSEIESQRVGRSILNVKGTGQLGGMK
VELTGSHNARLNGRITGTVNNEFFFLAQPFEIRLLTNNDGNVKISFPMKLTGKIDFLNNY
GLSLSSSIQQVSWQATGRFNQYRYAHNMSAGNNDDRIEAHVEMSGDANLDFLNIPLTIPQ
LH--IPYTGIQTPQ-LKDYSLWEQAGLRDLLKTTRQSFDLNLNAQYEKNKDMHAIPLPLA
TVHEALNKYIIFFNKYFERGRNTALDFLTKSYNEAKTKFDKYKIQTSLNKLPRTFRIPGY
TIPI---VNIEVSPFTAEMPAFGYMLPKEISTTGFTVPFIGFSVPSYTLVLP-SLELPVL
HVPQDLRTLKLPRFRINSPSNQILIPTMGNFTYDFSFKSSVITLTANAGLFNQSDIAGHL
SVSSSSAIDALQFKLDGSTSLTRKRGLKLATALSLNNNKFLEGSHDHSISLTKRNLEASM
ITNAKIKTPVFKMNFSQELSGNTKSKPTISSGLKVTYDFTTPKNGISSKGGVAHKLAIET
L-----TSYLSVDTSTKGNIDGAVYTGYSFSGAVDHEANTYLHANGVRSSVKLAANSKVD
GLWNSEMKEILAVEASTSRVYAVWEHSGKNYARYTPLFTTTGSQKCKATFELASWTVSAD
LQIQATQPNSFLDTASVNQVVLMKISPTDQKVGWKGEGQIQSISLRHDMQLSNEKSNAKF
DISGSLEGYMDFLKRINCPISKKSLWDILKLDVTTLADRKQYLNASASFIYTKSDNGYFF
PVPVIRLSDGFTFSIPELHLKAPSPVLSTPEFRVPFSTLQVPAYTIDLRNIKIPQTLNIM
PFDVNLPTLPKLRFPRVDVGANYITLKEYKIPYFEVTVPEYQITVSQFTLPKSISLGSFH
VDLDEVANKIADFDLPTITIPEQKIEIPPLKLSLPAGIYIPSFGALTGSLKVASPLYNVT
WRTDLTNKKESFEVSIDSTCSSTLQFLEYDLNVVSNYKYEEDKFVMKTTGSFAHRDLSAN
YMEDLAVLGFGKEGKILLR-----------VRFKQTNKKQIKLCHSTPVKRSKELTSQDD
S-KHTKIPYTYLVLC-FQSAPQKDIDILKSEI---SFRNSDVIQIKLNWKEDAAK-DLLL
GFKEKVPKMTSAVYKCVNRYYKEHMGLDISDATVIMKNMMQNNADKAYMFAVRQIDQLD-
-VQLRTAANEASDKYQEMKVKARQLYKRAA-DQAQQIDYQRIKARLLDATVDLMEEYHKK
IKHLIDSVIEFLKTTKFQVPGLSEKYTGEELYLMTTEKAAKTADICLSKLQEYFDALIVA
INELE----------VRVPASETILR-------------GRNVLDQIREMLKHLQEKIRQ
TFVTLREADF-AGKLNLLKQVV-QKTFQKAGNMVRSLQSKNFEDIKGQMQQLYKDAMASD
YAEQLRSLAENVQKYISQMK----NFSQKTLQKLSEKLHQLLLYIKSLREEYFDPTTLGW
SVKYYEVEEKVLGLLKNLIDTVVVWYNEYVKDLSDLVTQLTDQVRELVENYSQEYYDLIT
DVEGKGRQKVMELSSAAQEKVRYWSAVAKRKINELNRQVKTKLQEINGQLSDSQEKLINV
AKMLIDLTVEKYSTFMKYIFELLRWFEQ-ATADSIKPYIAIREGELRIDV----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------

-----------------------------------------PPPGSAMGPPRPALL----
--------------LLLLLGSGAWADDEVLEQAS-PSCPKDATR

PF01347 // ENSGT00590000083139_0_Domain_0 (105, 673)

FKHLRKYVYSYEAETS
SGVTGTADSRSVTKISCKVELEVPQLCSFVLRTSQCSLREASGVSPEGRALLKRARDSEE
FSATMSRYEL-RLTMPRGKRVSLYPEKDEPRHILNIKRGIVSALLLPPETEMTRRQL---
FTVRFWKAGGRAPRAHTRLHTHSRHWLTTRA----LPECDGFKATGSGVSPLALVRGMVR
PLSTMIGSSQSC-QYTLDSRKKHVSEAICKERHLFLPFSYKNQYGMMVHVTQSLKLEDTP
--KINSRFFEGG-AKEVGLAFENTRSTSPPKQ-AEAVLKTLQELQKLSISEQNAQRAKLF
SKLVTELRGLSHEAVKSLLPRLTEVSS--PITLQALIQCGQPQCYTQILQWLRNEKANPL
LMDVVTYLVALIPEPSAQRLREVFNMAKEQRSRATYYALSHVANNYYA-TFQEVTQDL-L
DIANYLLEEIRNDCTGDEEHTYLILRVIGNMGRTMEQVNPRLKSSVLKCIRSMEPSLLVQ
KAAIQALRKMALKEEVRGVLLQAFLNGAAPVDKRLAAYLMLMREPSQLEMNKIAQLLLQE
QSEQVKNFVASH

ENSGT00590000083139_0_Linker_0_3 (673, 709)

IANILNSEELSIHDLKKSVEEALKGSQ-LPTVMDFK

PF09172 // ENSGT00590000083139_0_Domain_3 (709, 1025)

KFSRNYHLSKSV
SLPSLA-PVSAKIEGNLIFDPNNYLPKDSMLKMTLTVLGFAPADLFEIGLEGKSFEPTLE
ALFGKKGFFPDSVNKALYWVDGQVPDHVSKVLVDHFGYTKGDKREQDMMNGIMVNVEKLI
KDLKSSEVPEARAYLRILGEELGFVRLHDLQLLGRLLLNAAHTLQGIPQMIG-EAIRKGS
NSDLFLHYIFMDNAFELPTGAGLQLHMSSAGVITPGTKAAVKLEMA-PMQAELVVKPSVS
LEFVTNMGITIPEFARSGVQMNINLFHESGLEARVALEAGQLKFTVPSPKRPVKLFSVSN
TLHL

ENSGT00590000083139_0_Linker_3_5 (1025, 1042)

VSTT----KTEAIPPPV

PF06448 // ENSGT00590000083139_0_Domain_5 (1042, 1156)

ENRQSWSACKPVFPGLSYCTTG-AYSNTSSTDASSYYPL
TGDSTLELELQPTGEVEQYTASATYDLQKEKNKNLDHTKCYLEKYSVKQTEASLTFRYNR
QRMTLSSEMQIPDFD

ENSGT00590000083139_0_Linker_5_6 (1156, 4658)

VDLGTILRVSGESAKEKKSYKLTLDMQSKKITEVALTGLVSYDGK
KEGRIKGVISIPHLQAEARSESLVHWSPTKLILQMDSS--ATVCGSTISKKWHGA-MMRE
VEFEWKTGTNVDTKKVASNLPV----DLSDYP-SLPVYTKSLLDRRVPHTNVTFWHMGSK
LIAATNTWLQKVSEHLPYAQILQDHLKGLEELNLQKMELPDFHIPQNLFLKSDGRIKYTL
NKNSVKVEIPLPLGGKSSKDLKILESVRTPALNFESVGFHLPSREFHIPTFTIPEVYQLH
VPLLGVLDLSTNVYSNVYNWSASYMGGNTST-N--HFSLQARYHVKADSVVDLLSYSVQG
SGETTYDHKNVFTLSCDGTLHHKF-LDSNIKFSHVETGGNNPASKGF---LTFDTSSAWG
PQMSASVHLDSKKKKHLYVKEVKVDGQLRVSSFYAKGAYGLSYQRDASTGQLGAESHLSV
NSSYVHGTNQITGRYQDGSLFLTSTSDLQDGIVKNAASLKYENYELTLNSDTSGKYEDFA
TSSKVDLTFSRQNALLRSENQANYKSLRFFTMLSGSLNSQGLELNADVLGTDRVNSGAHK
STLRIGQDGLSTSSTTNLKYSRLVLENELNAGLGPLGALVKLTMNGRFQEHNAKFSLDGK
ATLTEVSLGSTYQGMVLGVDSRNIFNFKLGKEGLKLSDDMMGSYADMQLDYANSLTIAGL
SLDFSSKLDHIYSSDKFYKQNLNLLLQPYSLVAMVNNDLKYSSLDVTNSGKLRLEPLKLS
VGGNIKGAYQNDEIKHIYTASYAGWS-ASYKADT---VAKIQGVEVSHRLSTDIAGLASA
VDVSTNYNSDSLHFSSVFRSAMAPFTVTVDVHTNANGKLVLWGEHTGQLYSKFLLKAEPL
ALTFSHDYKGATSHHLMSRKSLSTALDHKVSALLMPGEQAGTWKLKTQLNKNEYSQDLDA
YNTKDKIGVELRGRALADLTVLDVPIKVPFVLSEPVNVIDLLLMRDVVDQPQEFTVFASV
KYDKNQDVHTINLPFLKVLPEYFKRNQKAMVALLESLQKELKRIKIDQFVRKYRAALDKL
PQQISDYLNTLNWEGQVTNAKEKLAAFTKHYRITNDDLQIMLDDAKISFNEKLSQLQTYM
IQFDQYVKENYDLHDFKATIAKIIDQIIEKLKILDKHYHIHETLIKEILDLDVLIEKLDF
NQTGSSSASWIQNVDTKYQIRIQIQEKLQQIQTQVQNVDIQHLAEKLKKQAEAADLKMLL
YQLRTAIPTERIQDFIEQLKYVVVTIIEDFEITEKINAFSAKVHELIKKYEVDQQIQVLM
DKSVQLFHQYKLKETVEKLSDVIKQVDIKDYFKKLVGFIDDALEKLKAMNFGKFIEEVHR
FLDILVKKLRSFDYNQFVEETNNKIHEVTQRINGEIWALELPQKAEAI-RLFAEEVKAII
SVCLENLKDTKITSLIDWSHDALSSASFTYVTAKFQETLEDARDRLYQMDVQQELQRYLA
LVSQAYHTLVTYISDWWALAAKNLADFAQQYSIQDWAEHLKALVEQGFTVPEVQTIFGTM
PALEVSLRALQEATFQTPDFIVPLTDLRIPSVQINFKKLKDKNIPLKFTIPEFTILGTFH
VPPLTIDLVEMKLKIIRIIDQLLHSELQWPLPEVYLRDLKVDDTLLGRITLPNFSLPEIM
IPEIIIPNLILTDFQVPDLHIPEFQFPHISHTLEVPTFGKLSGTLKIQSPLFTLDTNAGI
QNVTT-SESKAEIVASLTAIGESKFEVLTFDFQANAQLSTPEV--NPLVVKESVTFSSKY
LRAEHGSEALVVGSTLTGKSHTVASLRTEKNTLELSNSVLVKTNKQFTLDSSTKYVHTLT
IPTLDFSSQADLRNEIKTLLEAGHIAWASSGTGSWKWAYPEFSDEGTHESQMSFTVQGPT
ASFGWSNKINSKHLRVNQNLVFESRFLNFSKFEIQSQVESQHMGRSDLTAKGTALLRDVR
AEVTGSHDAHLNGKVIGTLKNSLFFSAQPYEITASTNNEGNLKVGFPLKLSGKIDFLNNY
ALFLSPHVQQTSWQARGRYNQYNYNQNFSAGNNENSVEAHIGMNGEANLDFLNIPLTIPE
MT--MPYTSFTTPP-LQNFSIWEKTGLKEFLKTTRQSFDFSVKAQYKKNKEKHSL-----
------------------------------------------------------------
-----------------------------------TIPGSDFYMPSYTLALP-PLELPSL
HVPRNLHKISLPDFKVLSTLNNIFIPAMGNITCDFSFKSTVITLNTNAGLYNQTDIVAHF
LSSSSSVFEELQYKLEGTSSLTRKRGLKLATALSLS-NKFLEGSHDSTISLNKKNMEASV
TTTAKVQSPILRMNFKQDLNGNTKSKPTVSSSVELKYDFNSTKLHSTAAGAVEHKLSLET
L-----TSYFSIESSTKGNIKGTVLS-REYSGIIASETSTYLNSKGTRSSVKLQGASKVN
GIWNFKIEDNFAGEATLQRIYAIWERNMINRLSLKGLFLTHGEHTSKATLEFSPWEMSAL
VQVHANQSNSLLNIPSLSQELALNANTGKQKVSWKSKVQVDSGSLQNNVQLSNDQDEVRL
DTAGSLEGYLLFLKEIILPVYDKSLWDLLKLDKTTSIDRRQYLRASTALVYTKNPNGYTF
SVPVQELANEFI--IPGLKLSDPNSVLVTPTFQVPFTDLQIPSYTLDFGEIKISKKLSTP
SFALNIPTLPEVKFPRVDVLTKYSEPEGSTVAFFEISVPEYQLTMSQFNLPKRISVGSTV
LNLNKLANMIADFDLPTISIPEQTFELPSIKLSVPAGIFIPFFGALTAHFEVDSPLYNAT
WSAGLKNKADYIETFLKSTCGSTIDFLEYGLNVVTTHKIEDGMLVCETNGVFSHHDFNVN
YKEDDKYHGLQVWETGIRLNITSPLFTDVFVHYQTNAT-HLSSSADSPAVGTVGLDLEEN
D-DVLKWNF---YYL-PRSPPVKKLSIFETELN--YQESNDEILIDVNWEEEAAS-RLLS
SLKDNVPKATGALYDFVNKYHQEYTGLDLQDASSRLRRSLQ-----------RRIDEVG-
-VELQRAADSTAGTYEQWKDKAQNLYWELW-AQEGQTSFQRYKDEMYGHLARFLQELRGT
VL----QLIHFLRVSRFQLPGAARAYTGDELCNMVLREVGKVLSQVNSKIHEGLEILFSY
FQDDL---------KVKSLFDSRTQK---------LIDIFLEDVNLLK----FLSQEVQK
NLNDLQSINS-TKMLTNLRRSI-QSLFLDADRGIKYLKEKTFLYLINETQSEVMTVFNVH
IPFVFRLLKENLYNILGKFN----EFIQTIFQDASQELQQLHQYIKALREEYFDPSMIGW
TVKYYELEEKIIIQIQNLLAGLKDLYSKYRSQAADFASQLLNNTEESVHKNLQEYLSILI
DADGKGKEKIAELSATAQEIIKSWATAMKEMISDYQQ

PF12491 // ENSGT00590000083139_0_Domain_6 (4658, 4715)

QFRYKLQDFSDLLSDCYEKFIAS
STRLIDLSIQNYLMFLRFITELLEMLQS-TQAYDMNPYIKVASGELTINF----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------

-----------------------------------------------MGPQSPALR----
------LPLLLLLFLLLFLDTSVWAQDEVLENFS-LNCPKDATR

PF01347 // ENSGT00590000083139_0_Domain_0 (105, 673)

FKHLRKYVYNYEAESS
SGVRGTADSRSATKINCKVELEVPQLCSFIMRTSQCTLKEVYGFNPEGKALMKKTKNSDE
FAAAMSRFEL-KLAIPEGKQAVLYPDKDEPTHILNIKRGIVSALLVPPETAEDKQVL---
FLDTVYGNCSTQVTVNSRKGTVATEMSTERN----LQQCDGFQPISTSVSPLALIRGLVR
PLSTLVSSSQSC-QYTLDPKRKHISEAICSEQHLFLPFSYKNTYGIMTHVTQTLRLEDTP
--KTNSRFFSEG-TKRVGLSFESTKSTSPPKQ-VDAVLNTLQELKSLSVSEQNAQRANLF
NKLVTELRGLSDEAITSLLPQLIGVSS--PITLQALIQCGQPQCYTHILQWLKTEKAHPL
LVDIVTYLMALIPNPSTQRLREIFNTAKEQPSRATLYALSHVVNNYYD-ADHSRSPDL-Q
DIADYLLKQIDNECTGDEDHTYLILRVIGNMGRTMEQVMPALKSSVLNCVRSKKPSLQIQ
KASIQALRKMKLGDEVKEILFDTLMNGVDPVEKRLAAYLLLMKSPASSDISKIIQLLQWE
QSEQVKNFMASH

ENSGT00590000083139_0_Linker_0_3 (673, 709)

IANILNSEELYVQDLKKLIKDAPEYSQ-LPTIMDFK

PF09172 // ENSGT00590000083139_0_Domain_3 (709, 1013)

KFSRNYQISKSV
SLPSFD-PVSAKMEGNLIFDPNSYLPKESMLKTTLTVFGLASVDLFEIGLEGKGFEPTLE
ALFGQQGFFPDSVNKALYWVNGQVPDRVSKVLVDHFGYANNEKHEQDMVNGIMPMVDKLI
RELKSKEIPEARAYLRILGEELGFVKLQDLQVLGRLLLNGAQTLRGIPQMIA-QAIRDGS
NNDFFLHYIFMDNAFELPTGLGVQLQVSSSGVITPGTKAGVRMELA-NIQAELVAKPSVS
VEFVTNMGIIIPDFAKSGVQMNTNFFHESGLEARVALKAGQLKVIIPAPKKP

ENSGT00590000083139_0_Linker_3_5 (1013, 1044)

VN-----N
TLHLVSTT----KTEVIPPLIEN

PF06448 // ENSGT00590000083139_0_Domain_5 (1044, 1156)

RQSWSTCKPFFTGMNYCTTG-AYSNASSTESASYYPL
TGDTRYELELKPTGEVEQYSASATYELQKEDKSLVDTLKFLVQAEGVQQTEATAVFKYNR
RSRTLSSEVLIPGFD

ENSGT00590000083139_0_Linker_5_6 (1156, 4658)

VDFGTILRVNDESSKDKNAYKLILDIQNKKITEVSLVGHVSYDKK
GDGKIKGVVSVPHLQAEARSEIHTHWSPTKLLFQIDSS--ATAYGSTISKRVVWRYDNEK
IEFDWNAGTNVDTKKVASNFPV----DLSSYPRTLHEYANSLLDHRVPQTDMTFRHMGSK
VIVATNTWLQMASRGLPYSQILQDHLNGLSELNLQKMGLPDFHIPDNLFLKSDGRIKYTL
NKNSIKLDIPLPLGGKSSKDLKIPERVRTPDLNFKFMGFHLPSQVFQVPTFTIPKTYQLQ
VPLLGVLDLSTNVYSNLYNWSASYTGSNTSR-D--HFSLWAQYRMKADSAVDLFSYSMQG
SGETTYDSRSTFTLSCDWSLHHKF-LDSKFKVSHVEKFGNTPVSKGL---LTFEASSAWG
PQMSATVHLDSEKKQQLYVKHIKVDGQFRASSIYAQGKYGLSCERNPTTGQLSGESNMSF
NSTYLQGTNQIVGIYQDGTLSLTSTSDLQDGIFKNTASLKYENYELTMKSDSSGHYENFA
ASNKLDMTFSKQSASLRSEHQANYKSLRLVTLLSGSLTSQGMELNADILGTDKMNSGAHK
ATLKITRDGLSTSATTNLKYSPLLLENELNAELGLSGASMKLSTNGRFKEHHAKFSVDGK
AALTEVSLGSIYQAMILGADSKNIFNFKLSREGLKLSNDLMGSYAEMKLDHTHSLSITGL
SLDLSSKMDNIYSADKFYKQNFNVQLQPYSFLTTLSNDLRYNVLDLTNSGKLQLEPLKVN
VGGNFKGVYQNNELKHIYAISYTDLVVASYRADT---VAKVQGIEFSHRLNADIEGLASS
VDVTTYYNSDPLHFNNVFHFVLAPFTLGIDTHTSGDGKLSLWGEHTGQLYNKFLLKAEPL
ALAFSHDFKGSTNHDLVYKNSISTALDHSFGALLTPAEQTSTWKFKTRLNDKVYSQDFEA
YNTKDKIGVDLSGR--AELSGLYSPFKVPFFHSEPVNVLSDLEINDAEDKPQEFTIVAFV
KYDKNQDVHTISLPFFKSLPEYLERNRRGIITLLEAMQGELQRINIDQFVRKYKAALSRL
PQQIRDYLNASDWERQVTNAKEKLTAFMENYRITDNDVLIALDSAKINFNEKLSQLETYV
IQFDQYIKDNYDPQYFKKTIAQIIDRIIEKLKILDEQYHIRVNLEKSIHNLYVFVENVDL
NKIGSSTASWIQNVDTKYQVRIQIQEKLQQLRTQIQTIDIQQLATELKQQIETIDFTMHL
DQLRTAILFQRVNDIIERVKYFVMNLIEDFKVTEKINTFRAIVHELIEKYEVDRQIQVLM
DKSVELAHRYSLGETLQKLSNVLQQIEIKHYYEKFVGFIDDTVKWLKALSFKNYIEELNR
FLDMLVKKLKAFDYHQFIDETNSKIREVTQRINAEIQALELPQKTEAL-KLLVEGFKATV
SNYLERLKDTKVTVFIDWLQGAL-----VHIKAHFQDTLEDVRDRLYQMDIQWEFEHFLS
LVSQVYNTLVTYISDWWSLTAKNITDFAEQYSIQNWAETVKLLVEQGFTVPEIQTFLGTM
PAFEISLRALQEANFQTPDFIVPLTDLRIPSIRINLKMLKNVKIPSRFSTPEFTLLNTFH
VRSFTIDLLEIKAKIIRTIDQMLNSEIQWPLPEVYLRDLEIVNISLARLTLPDFHVPEMT
IPEFTIPNVNFKEFRVPDLHIPEFQLPHLSHTIEMPAFGKLHGILKIQSPLFILDANANI
QNVTT-SENKAEIMASITATGESKFEALNFDFQAQAQFLELTP--NPLVLKESMNFSSKH
VRMEHEGEILFSGKSIEGKLDTVASLHTEKNMVELNNGMIVRLNNQLTLDSHTKYFHKLS
IPRLDFSSKASFNNEIKTLLEAGHVAWTSSGTGSWNWACPNFSDEGTHSSRISFTVEGPI
ASFGMSNNINGKHLRVIQKLAYESGFLNYSKLEVESKVESQHVGSSILTGKATVLLREAK
AEMTGEHNAELNGRVIGTLKNSLYFSAQPFMITASTNNDGNLKVSFPLKLTGKIDFLNNY
ALFLSPHAQQASWQASARFNQYKYNQNFSAINNEHNMETHIGMNGDANLDFLNIPLTIPE
MN--LPYIGLTTPL-LKDFSIWEETGLKEFLKTTKQSFDLSVKAQYKKNRDKHSIAIPLS
GFYEFILNKVNSWDRKFEKVRDSALDFLTASYNEAKNKFE-----NSLIQPPRTFQSRGY
TIPF---VNIEVSPFTVETLASSHVIPKAISTPSVTIPGPNVIVPSYRLVLP-SLELPVF
HAPRNLLKFSLPAFKELKTIDNIHIPALGNFTYDFSFKSSVITLNTNAGLYNRSDIIAHF
LSSSSFVTDALQYKLEGTSRLTQKRVSKLATAISLT-NKFVKGNHDSTISLTKKNMEALV
KTTANLHVPILTMNFKQELNGNTKSKPTVSSSIELNYDFNSSKLHSTAKGGVNYKFSLES
L-----TSYFSIESSTKGNIKGSVLS-QEYSGSVTSVANTYLNSKGTRSSVSLQGASKVD
GVWNLEVEENFAGEATLQRIYATWEHNNNNYFQVDSFFVTKGKQTYRATLELSPWTMSTL
LQVHMSQPSSLLDLHHFDQEVTLKANTKNQKVNWKSEVQIHSQVLRHNVQFSNDQEEVRL
DIAGSTDGQLWDLETIFLPVYDKSLQELLQMN-----GKRQYLQASTSIVYTKNPNGYLF
SLPVQELADQFI--IPGLKLNN-------------------------FNGIKIYKKLSTS
PFALNLTMLPKVNFPGVDVLTQYSKPEGSSVPTFQVTIPEVQLTVSQFTLPK------TG
FDLNEIANRIAEVDLPSITLPEQTIKVPPFKFSVPSGILIPFFGALTAQVGVASPVYNAT
WSAGLKNKADHVETFLDSTSSSIWQFLEYELKVVGTHKIEDHMFICKNKGTLQHRDFNVE
YNEDGVFKGLWVWQGEARLDITSPALTELRLLYKEDET-SLSASVASPAIGIVGLESSTD
Y-HSVKLNV---YFY-PQSPLDRKLSIFKTEWR--CKKNDDGMHIKINWEEEAAS-RLLG
SLKSNVPKATEALYDYVNKNYLGNT-------SLELRRSLQNNVES----AIRTIDAMN-
-MDFQRAAH---D--------TQNLYEEML-AQEGQSIPERLQEKALDSLVHVTQMYHKE
VMFLTDSFIRFLKYNTFHLPGNAGTYTTDELCTLVMGETAKLLSR----IHNSLEKLLSY
VQDLVEKSSLISDMELKFPFISKTRT---------LKDAILEYRNIIN----TLQ-----
------NTKF-TTILSELQGFL-DRILDIIVEQIQCLSD--NACFTDYINA-V---FKIN
VPDAFKFLREDLYAIFREFH----DSAQSILQEGSYKLQQAYQYIKALREEYFDPSMVGW
TVKYYAVEEKMVDLIKSLLVILRDFHSKYSARATDFDSKITTQVEQFMSRDMQEYSSILI
DINGKGKEKIAKLSIMAKEAFKNWATAMKETISDYQE

PF12491 // ENSGT00590000083139_0_Domain_6 (4658, 4714)

QFSFKLQDFSVQLSEYFEKFLAE
STRLIDLSIQSYHVFLRYITELLKELQV-ATTNNVSPYINRAPGELVITF----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------

------------------------------------------------------------
--------------------------DEVLENVS-PSCPKDATR

PF01347 // ENSGT00590000083139_0_Domain_0 (105, 673)

FKHLRKYVYNYEAESS
SGVPGTADSRSSTKINCKVELEVPQLCNFILKTSHCTLKEVYGLDPEGKALLKKTKNSEE
FAAAMSKYDL-KLAVPEGKQVLLYPEKEEPKHILNIKRGIISALLLPPETEKAKQVL---
FLDTVYGNCSTDFTVKTKKGNVATEISIERN----LRKCDHFQPISTGVSPLALIRGMTR
PLSTLIGSSQSC-RYTLDPRRKHVSEAICNEQHLFLPFSYKNKYGMMAQVTQTLKLEDTP
--KINSRFFEEG-TEAVGLAFESTRSTSPPKH-AEAIVKTLQELQKLHVSEQNAQRANLF
HKLVTELRGLSSEAVTSLLPKLIEVSS--PITLQALIQCGQPQCYTHILQWLKNERANPL
LIDAVTYLVALIPEPSAERLREVFNTARVQQSRLTFYALSHMINNYHK-TNPTWTQDL-L
EIADYLSEQIGNDCTGNEDLTYLILRVIGNIGKTMEQLTPKLTSSVLKCIRSEQPSLVIQ
KAAIQALRKMELSDEVREVLLQTFLDDTSPGDKRLAAYLMLMGSPSQSDISKITQLLPRE
QNEQVKNFVASH

ENSGT00590000083139_0_Linker_0_3 (673, 709)

IANILNSEDLYVQDLKSLVEEALKKSQ-LPTIMDFK

PF09172 // ENSGT00590000083139_0_Domain_3 (709, 1025)

KFSQSYQFSKSI
SLPSLD-LVSAKIEGNLIFDPNNYLPKESMLKTTLKVFGFASADLFEIGLEGKGFEPTLE
ALFGKEGFFPDSVNKALYWVNGRVPDRVSKVLVDHFGYTKDDKHEQDMVNGIMFNVEKLV
KDLKSKDFPEARAYLRILGEELGFVRLHDLQLLGKLLLKGVHTLQGIPQMIK-ELVRKGS
ASDLFLHYIFMDNAFELPTGLGLQLQVSSSGIITPGLKAGVKLEVA-NMQAELVTKPSVS
VEFVTNMGIVIPDFARSGVQMNTNFFHETGLEARVVLKAGQLKFIIPSPKRPVRLFSGSN
TLHL

ENSGT00590000083139_0_Linker_3_5 (1025, 1042)

VSTT----KTEAIPPLI

PF06448 // ENSGT00590000083139_0_Domain_5 (1042, 1156)

ENRQSWSTCKPFFIGLNYCIMG-AYSNASSTDSSSYYPL
TGDTRFELELKPTGEVEQYSAKAFYELRRDGEALVDMLKLVTQTEGVKQTEATLLFRYNR
QSKTLSSELHIPDFD

ENSGT00590000083139_0_Linker_5_6 (1156, 4658)

VDLGTVLKVSYDPSKEKKSYKLTLDFQNKKITEVTLTGHISYDRR
EEGKIKGVISIPRLQAEARSEILSLWSPSKLLLQMDSS--ATAYGSTISKKVAWRYDGEK
IEFEWNTGINVDTKKATSNFPV----DLSALPKSLHTYANILLDRRVPQTDLTFRHMGSK
LVAAASTWLQETSRSLPYAQNIQDQLSGLQELCLQKMKLPNFYIPENLFLKSDGRIKYTL
NKNSMEIEIPLPFGGRSSEDLKMFKTIQTPALNFQPLGFRLPSQEFQIPTFTIPHLYPLR
LPLLGVLDLSTSIYSNLYNWSASYTGGNTST-D--HWSLQAQYHVKADSVVDLLSYHVQG
SGKTAYDHRNTLTLSGDGSLHHKF-LDSNVKFNHVEKRGNSPASKGL---LTFDASSAWG
PQISASVHLDSKKKEHLYVKEVKIDGQFRASAFYAKGAYDLSYQRDPATGQLTGESNLRF
NSSYVQGTNQITGRYDDGTVSITSTSDLQDGLVKNTASLKYENYELTLKSDTNGKYEDFA
TSNKVDLTFSKQNALLRSEYQADYKSLRFFTLLSGSLNSHGLELNADIMGTDKINSGAHK
ATLRIARDGMSTSATTSLKYSPLVLENELNAAVSLSGASLKLTSNGRFREHHAKFSLDGK
AAPTEVSLGSAYQAMILGVDSKNIFYFKINQEGLKLSNDIMGSYDEMKLDYTNNLNVVGF
SLDFSSKLDNIYSSDKFYKQNFNLQLEPYSLVTTLNNDLKFNALDMTNSGKLRLEPLKLN
VGGTIKGAYQNDEIKHIYTLSYADLS-ASYKADT---VAKVQGTEFSHRLNTNIAGLAST
VDISTSYNSDSLHFSNAFRSAVAPFTMTIDTHTNGNGKLVLWGQHTGQLYSKFLLKAEPL
AFTFSHDYRGSTSHHLTSRRSVTTALDHKVSALLTLAEQTGNWKLRTRLNQNEYSQDFSA
YNTKDKVGVELSGRALADLTVLDFPIAVPLVLSKSINVIDTLEMRDSVGQPQEFTLVASV
KYDKNQNAHTIHLPFFKFLPKYFEKTRVVVIGALGAVQKELKRTHIDQHMRKCMAALDRL
SQQVSDYLSTFNWERQVLSAKEKLTAFTENYRMTENDLQIVLDNAKINLNEKLSQLQTYV
IQFDQYIEDNYDLHDFKTTVAKIIDQIIEKLKILDEHYHIRANLVKKIRDLYFFIENFDF
NKVGSSTASWIQNMDTKYQIRIQIQEKLQQLKVQIQTVDIHHLAEMFKQQVEAVDIRVLL
DQLRTTIPFQRIKEIIEHVKYRVTSLSEGFEVTEEIKAFRVMVHEFIEMYKIDQHIQALM
DKSVQLAQQYKLQETVQKLSSVLQQVKMAEIVEKLIRLTNNALKQLEALSFNQFLEEVNK
FLDMLVKKLRSFHYHQFVDETNNKIHEVTQRINDEIQALGLPQKAKAL-RLLVEDARIVV
SAYLENLKTTKITLFLDRLQEALSSTSVTYMKAKFQETLEDFRDRVYQMDVRQELQRYLF
LVGQVYNTLVTYISDWWALAAKNLTDFAEQYSIQDWAENLKTLVEKGFTIPKIQTTFGTI
PAFEISLRALQEATYQTPDFTIPLTDLRIPSFQINFKTLKDVKIPSSFSTPEFTILNALH
VPSFTIDFIEIKIKIIRTIDQMLNSELQWPVPEVYLGDLSGVDAILAGITVPDFHLPEIT
IPEFVIPNLNLTDFQLSDLHIPDFQLPRISHTIEIPAFGKLYGILKIQSPFFTLDANTDI
QNATA-SENQVEIEASISAKGASRLEVLNFDFQAKAQLSDPTI--NPLVLKESVRFSSKY
LKTEHESEMLWVGNAIEGKTNTMAGIHTEKNTLELSNGVLVKINNQLTLDSNTKYFHKLN
IPQLDFSSQADLHSDLKTLLEAGHIAWASSGTASWKLACHEFSDEGTHESQSSFTVEESI
TSFRLSNKINSKHLRVNQKILYESRFLNFSKFEIQSQAECQHVGRSVLTAKGLALLQEGK
AEITGNHDAHLNGKVVGTLKNSLFFSAQRYEMTASTNNEGNLRVSFPLKLTGKIDFLNNY
ALFLSPSTQKASWQASGRFNQYKYHQNFSAGNNEKSIEAHIGINGEANLDFLNIPLTIPE
MT--LPYTKLSTPQ-MKEISLWEKTGLKDFLKTTKQSFDLSVRAQYKKNKDKHSIPVPLD
AFYALIHRNINSFSRLFKTVRNQALDFFIKSYNEAKTTFDKYKVEKSLNQQPKIYKIPGY
TIPV---ANIEVSPFTVKMLTFEYMIPKEISTPSITVLGSGIYVPSYTLVLP-FLELPTL
HVPKELSELSLPEFKVLSTINKILIPALGNMTYDFSFKSSVITLNTNVGLYNQSDIVAHF
LTSSSSVMDALQYKLEGTSSLTRKRGLKLAAALSLS-NRFVEGNHDSTISFTKKNMDASV
TTTARVQIPILKMTFKQQLHGNTKSKPAVSSVIELKYNFNSPKLLSAAMGAVTHKLTLES
L-----TSYFSIESSTKGSVEGSFGS-QGYSGSLASEASTYLNSKGTRSSVILQGASKAD
GLWDLKVKENFAGETTLQRIYTIWEQNIKNHLELGGLILTSGEHTSKATLELSLWKISAL
VQVHAHQPSSLLKINYLGQEVSLNVNTENQKISWKSQVQVHSGSLQNNIQLSNDQEVARF
DMAVSLEGHLRFLKDTVLPVYDKSLWDLLKLDVTTSLNRKQYLRAATAVIYTKNPNGYLV
SIPMQELDDKFI--IPGLKRNNQNSVYVTPTFQVPFTDLQVPSYTLDLSEIEIYKKLCTL
PLTLNVSTLPKVKFPRVDVLIQYSKPEASSVPFFEITVPASQLTVSHFTLPKSISVGSTV
LDLNAVASNIADFELPTITVPEQTLEIPSMKFSVPAGILIPSFGTLTARFEVASPLYNTT
WSAGLKNKGDHVETFLDSTCSSTIQFLEYDLNVVGTHKIEGGMLVYKTNASFAHRDFSAE
YEEDGKYQGLGYWNGKVDLNITSPTLTDVCLHYQENEN-HFFSSVASPAIGTVVIDVKNI
SDTLLGWNL---YYR-PQASPDKILNIFKIELR--VLELDDEVQIKANWEEGAVS-ELLS
SLKDSVPRATGALYDYVNKYHQEYTGLDLKDASLKLRRGLQDSADQVYQGAMRQIDEVD-
-MELQRMARGTTETYQQWKDKAQSLYQELL-AQEDRSGFQRLQKKVSDSLIGVTQGYNVT
VKRATDLLIDLLSVTRFQLPGRARNYTADELCTVVIQEIAKRLSQVHSNIHNGLHILFSY
LLYLIEESELYKDLNNKFSFTSMHNQ---------LISMVLEYVKMSI----FFSQEIQK
ALSYLQSTMM-TEMLSDLQRSR-QDTFQEIERELKCFKEKKLADFINQTLQNINTIFDIY
ISFVFRFLKENLDYNFVEFN----ELIQNKLQVASQELQQLHQYVQALHQEYFDPATVGW
TVKYYEFEEKIINLIKNLVDVLKDFHSKYAVGAADFASQLSSQIKTLIQKYLQEYLRILA
NAEEKGKEKITELSTSAQEVIKSWAVAVKEIISDYHQ

PF12491 // ENSGT00590000083139_0_Domain_6 (4658, 4715)

QFTYKLQEFSDQLSDYCEKFISE
SKRLIDLSIQNYHMFLNYIMELLKELQS-ATVNDMSPYIKVAPGEFTITF----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------

-----------------------------------------------MGRPRPALL----
AL---PALL-LLLAGARAEKE----M---LENVS-VVCPRDATR

PF01347 // ENSGT00590000083139_0_Domain_0 (105, 673)

FKHLRKYTYNYEAESS
SGVPGTADSRSATRINCKVELEVPQLCSFILKTSQCTLKEVYGFNPEGRALLKKTKNSEE
FAAAMSRYEL-KLAIPEGKQVFLYPEKDEPTHILNIKRGIISALLVPPETEETKQVL---
FLDTVYGNCSTHFTVKTRKGNVATEISTERD----LGQCDRFKPIRTGISPLALIKGMTH
PLSTLISSSQSC-QYTLDAKRKHVAEAICKEQHLFLPFSYKNMYGMGVQVTQTLKLEDTP
--KINSRFFGEG-TKKVGLAFESTKSTSPLKQ-AEAVLKTLQELKKLTISEQNIQRANLF
HKLVTELRGLSDEAVTSLLPQLIEVSS--PITLQALVQCGQPQCSTHILQWLKRVHANPL
LIDVVTYLVALIPEPSAQQLREIFNMAREQRSRATLYALSHAVNNYHK-TNPTVTQEL-L
DIANYLMEQIQDDCTGDEDYTYLILRVIGNMGQTMEQLTPELKSSILNCVQSTKPSLMIQ
KAAIQALRKMEPKDKDQEVLLQTFLDDASPGDKRLAAYLMLMRSPSQADINKIVQLLPRE
QNEQVKNFVASH

ENSGT00590000083139_0_Linker_0_3 (673, 709)

IANILNSEELDIQDLKKLVKEALKESQ-LPTVMDFR

PF09172 // ENSGT00590000083139_0_Domain_3 (709, 1017)

KFSRNYQLSKSV
SLPSLD-PASAKIEGNLIFDPNNYLPKETMLKTTLTAFGFASADLFEIGLEGKGFEPTLE
ALFGKQGFFPDSVNKALYWVNGQVPDGVSKVLVDHFGYTKEDKREQDMVNGMMFSVQKLI
EDLKSKEVPEARAYLRILGEELGFAKLHDLQFLGKLLLMGARTLQGIPQMIG-EVIRKGS
KNDFFLHYIFIEKAFELPTGAGLQLQISSSGVTAPGIKAGVKLEVA-NMQAELVAKPSVS
VEFVTNMGIIIPDFARSGVQMNTNFFHESGLEARVALKAGQLKFIIPSPKRPVKLL

ENSGT00590000083139_0_Linker_3_5 (1017, 1044)

SGSN
TLHLVSTT----KTEVIPPLIEN

PF06448 // ENSGT00590000083139_0_Domain_5 (1044, 1156)

RQSLSVCKQLFTGLNYCTSS-AYSNASSTDSAPYYPL
TGDTRLELELRPTGEVEQYSVSATYELQREDRALVDTLKFVTQAEGVKQTEATMAFKYNR
QSMTLSSEVQIPDFD

ENSGT00590000083139_0_Linker_5_6 (1156, 4658)

VDLGTILRVNDESTEGRKSYRLTLDIQNKKITEVTLMGHLSCDTK
EEGKIKGVISIPRLQAEARSEILTHWSPAKLLLQMDSS--ATAYGSTVSKRVAWRYDEEK
IEFEWNTGTNVDTKKMTSNFPV----DLSEYPRSLHMYADRLLDHRVPQTDMTFRHMGSK
LIVATNSWLQKASGSLPYIQTLQDHLNSLKELNLQNMGLPDFHIPENLFLKSDGRVKYTL
NKNSLKVEIPLPFGGKSSRDLKMLETVRTPALHFKSVDFHLPSREFQVPTFTIPKLYQLQ
VPLLGVLDLSTNVYSNLYNWSASYTGGNTST-D--HFSLRARYHIKADSVVDLLSYNVQG
SGEATYDHKNTFTLSCDGSLRHKF-LDSNIKFSHVEKLGNNPVSKGL---LIFDASSSWG
PQMSASVHLDSKKEQHLFVKEVKIDGQFRVSSFYAKGTYGLSCQRDPNTGRLNGESNLRF
NSSYLQGTNQITGRYEDGTLSLISTSDLQSGIIKNTASLKYENYELTLKSDTNGKYKNFA
TSNKMDMTFSKQNALLRSEYQADYESLRFFSLLSGSLNSHGLELNADILGTDKINSGAHK
ATLRIGQDGVSTSATTNLKYSPLVLENELNAELGLSGASMKLTTNGRFREHNAKFSLDGK
AALTELSLGSAYQAMILGVDSKNVFNFKISREGLKLSNDMMGSYAEMKFDHTNSLNIAGL
SLDFSSKLDNIYSSDKFYKQNFNLQLQPYSLVTTLNNNLKYNALDLTNNGKLRLEPLKLH
VAGNLKGAYQNNEIKHIYTISSAALS-ASYKADT---VAKVQGVEFSHRLNTDIAGLASA
IDISTNYNSDSLHFSNVFHSVMAPFTMTIDTYTNGNGKLALWGEHTGQLYSKFLLKAEPL
AFTFSHDYKGSTSHHLMSRKSISTSLEHKVSALLTPAEQTGTWKLKTQFNNNEYSQDLDA
YNTKDKIGVELSGRALADLTLLDYPIEVPLLLSEPVNVIDALEMRDAVEKPREFTIVAFV
KYDKNQEVHTINLPLFETLQEYFERNQRTIIVVLENMQRHLKRINIDQFVRKYRAALGKL
PQQANDYLNSFNWERQVSRAKEKLIALTKKYRITENDIQIALDDAKINFNEKLSQLQTYM
IQFDQYIKDNYDLHDLKIAIANIIDQIIEKLKSLDEHYHIRVNLVKTIHDLHVFIENIDF
NKIGSSTASWIQNVDTKYQIRIQIQEKLQHLKRHIQNIDIQHLAGKLKQHVEAIDVRVLL
DQLGTTISFERINDVLEHVKHFVINLIGDFEVAEKINAFRAKVHELIERYEVDQQIQVLM
DKLVELAHQYKLKETIQKLSNVLQQVKIKDYFEKLVGFIDDAVKQLDELSFKTFIEDVNK
FLDMLIKKLKSFDYHQFVDETNNKIRELTQRLNGEIQALELPQKAEAL-KLFLEETKATV
AVYLESLQNTKITLIIDWLQDALNSASLAHMKAKFRETLEDTRDRIYQMDIEKELQRYLS
LVGQVYSTLVTYISDWWTLAAKNLTDFAEQYSIQDWAKHVKALVEQGFTVPEIKTILGTM
PAFEVSLQALQKATFQTPDFIVPLTDLRIPSVQINFKELKDIKIPSRFSTPEFTILNTFH
IPSFTIDSVEIKVKIIRTIDQMLNSELQWPIPEVYLRDLKVEDIPLARITLPDFHLPEIA
IPEFVIPNLNLNDFQVPDLHIPEFQLPHISHPIEVPTFGKLYSILKIQSPLFTLDANADI
GNGTT-SANEAGIAASITAKGESKLEVLNFDFQANAQLSNPKI--NPLALKEFVKFSSKY
LRTEHGSEMLFFGNAIEGKSNTVASLHTEKNILELSNGVILKINNQLTLDSNTKYFHKLN
IPKLDFSSQADLRNEIKTLLEAGHIAWTSSGKGSWKWACPRFSDEGTHESQISFTIEGPL
TSFGLSNKINSKHLRVNQNLVYESGSLNFSKLEIQSQVDSQHVGRSVLTAKGTALFGEGK
AEFTGRHDAHLNGKVIGTLKNSLFFSARPFEITTSTNNEGNLKVSFPLRLTGKIDFLNNY
ALFLSPSAQQASWQVSTRFNQYKYNQNFSAGNNQNIMEAHVGINGEANLDFLSIPLTIPE
MP--LPYTTITTPP-LKDFSLWEKTGLKEFLKTTKQSFDLSVKAQYKKNKHRHSITNPLA
VLYEFTSQNIKSFDKHFEKARSNALDFVTKSYNDAKIKFDKYKAEKSHDELPRTFQIPGY
TVPV---VNVEVSPFTVEMLAFGYVIPKAISMPSFTILGSDIRVPSYTLILP-SLELPVL
QVPRNL-KLSLPDFKELCTISHIFVPAMGNITFDFSFKSSVISLNTNAEVFNQSDIVAHL
LSSSSSVIDALQYKLEGTTRLTRKRGLKLATALSLS-NKFVEGSHDSTVSLTKKNMEASV
ATTAKVQIPILRINFKQELNGNTKSKPTVSSSMEFKYDFNSSMLYSTAKGAVDHKLILES
L-----TSYFSIESSTKGDVKGSVLS-RDFSGTIASEANTYLNSKNTRSSVKLQGTSKID
DIWNLEVNENFAGEATLQRIYSLWEHSMKNHLKLEGLFFTNGEHTSKATLELSPWEMSAF
VQVQASQPNSFLDILHLGQEVALNTNTKNQKIRWKNEVRVHSGSFQNHVELSNDQEKAHL
DIAGSLEGHLRFLKNIILPVYGKSLWDFLKLDVTTSIGRRQHLRVSTAFVYTKNPNGYSF
SIPVKVLADEFI--IPGLKLNDLNSVLVMPTFHVPFTDLQVPSYKLDFREIKIYKKLRTS
SFALNLPALPEVKFPEVDVLTKYYQQEDSLIPFFEITVPESQLTVSQFTLPKSVSVGSAV
LDLNAVANKIADFELPTIIMPEQTIEIPSIKFSVPAGIFIPSFRALTAHFEVDSPLYNAT
WSASLKNKADHVETVLDSTCSSTIQFLEYKLNVVGTHRIEDGMLASKTKGTFAHQDFSAE
YEEDGKYEGLREWERKVHLDIKSPAFTDLHLRYQKDKK-GVSTSAASPAIGTMGMDV---
--DFSKWNI---YYS-PQSSPNKKLTIFKTELR--FPESDEEIQIKVNWEEEAAS-GLLT
SLKDNMPKATGALYDYVNKYHWEHTGLTLREASSKLRRNLQSNAEWVYQGAIRQIDDID-
-LQFRKAASGTTGTYQEWKDKAQNLYQELL-TQEGQTSFQGLKDKVFDGLVRVTQEFHMK
VKHLIDSLIDFLNFPRFQFPGKPGTYTREELCTMFIREVGMVLSQVYLKVHNGSEILFSY
FQDLV----------ITLPFELRTHK---------LIDVISMYREWLK----VLSKEAQE
VFKDIQSLKT-TEVLRNLQDLL-QFIFQLIEDNIKQLKEMKFTYLINYIQDEINTIFNDY
IPYVFKLLKENLCLNLHKFN----EFIQNELQGASQELQQIHQYIMALREEYFDPSVVGW
TVKYYELEEKIVRLIKNLLVALKDFHSEYIVSASDFTSQLSSQVEQFLHRNIQEYLSILT
DTDGKGKEKIAELSTTAQEIIKSQAIAMKEIISDYHQ

PF12491 // ENSGT00590000083139_0_Domain_6 (4658, 4715)

QFRYKLQDFSDQLSDYYEKFIAE
SKRLIDLSIQNYHTFLIYIMELLKKLQS-TTL--MNPYVKLAPGELTIIL----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----MSKY

PF01347 // ENSGT00590000083139_0_Domain_0 (189, 673)

EL-RLAVPEGKQVVLYPADKEPKHILNIKRGMVSALLVPPETEEAEREL---
FLDTVYGNCSTHVTVKTRKGSVATEMSTDRN----LRQCSGFQPVSAGASPLALIRGLAR
PLSTLISSSQSC-QYSLDPKRKHVSEATCKEQHLFLPFSYKNKYGMMTQVTQTWKLEDTP
--KTNSRFFGEG-TQKVGLAFESTKSPSLPKQ-AEAVLKTLQELKALSVSEQNAQRANLF
NKLVTNLRGLSNEAVSSLLPQLIEVSS--PITLQALVQCGQPQCYTHILQWLKSEKAHPL
LIDAVTYLVALIPDPSVQRLREIFSIAKEQQSRATLYALSHVASSYFQ-TTHTVNQDL-Q
DVANYLQEQIRDTCAGDEDHTYLILRVIGNMGRTLESITPAIKSSVLSCIRSPKPSVLIQ
KAAIQALRKMELGDEAQELLLQTFVDSTFPVEKRLAAYLMLMKGPSQADVNKVIGLLPRE
GNEQVKNFVASH

ENSGT00590000083139_0_Linker_0_3 (673, 709)

IANILNLEELYVGDLKTLVREALKDSQ-LPTIMDFR

PF09172 // ENSGT00590000083139_0_Domain_3 (709, 1017)

KYSRNYHFSKSV
SLPLLD-PVSAKIEGNLLFDPNNYLPKESMLKTTLTVFGFASADLFEIGLEGKGFEPTLE
ALFGKQGFFPDSVSKALYWVNGQVPDHVSKVLVDHFGYTQDDKHEQDMVNGIMPIVNKLI
KDLKSRDMPEARAYLRILGKELGFFKLQDLQFLGRLLLSGARTLQGVPQMIG-EAIRKGS
ERDLFLHYIFMDNTFELPTGAGLQLQVSSSGVITPGIKAGVKLEVA-NMKADLLMKPSVS
VEFVTDMSVIMPDFARSGVQMNTNFFHESGLEARMALKAGQLKFIIPSPQRPVKLF

ENSGT00590000083139_0_Linker_3_5 (1017, 1044)

SGRN
TLHLVSTT----KTEVIPPLIED

PF06448 // ENSGT00590000083139_0_Domain_5 (1044, 1156)

RQSWSACRPFIAGLSYCTTG-AYSNASSTQSASYYPL
TGDTRYELELKPTGEVEQYSASATYELQKEDKALVDRLKFVIQAEGVKQTEATLMFRYNR
RSRTLSTEMQIPDLD

ENSGT00590000083139_0_Linker_5_6 (1156, 4659)

VNLGTVLRVSDESSKDKKSYKLNLDIQNKKITEIAFSGHISHDTK
GDGKIKGVVSIPRLQAEARSEILSHWSPTKLLLQMDSS--ATAYGSTVSKRVMWRYDDEK
IEFEWNTGTNVDTKKVASNFPV----DLSGYLRSLEMHARGLLHHRIPQADMSFWDMGSK
LIATTNTWLQEASGHLPYAQILQAHLSGLTQMDLQKMSLPYFHMPDNLFLKSDGQVKYTL
NKNSIEVEIPLPFGGKSSKDLKIFETIRTPALNFKSVGLHLPSREFQVPTFTIPELYHLR
VPLLGVLTLSTNVYSNLYNWSASYTGGNTSR-D--HFTLQARYHVKADSVVNLLSYSVQG
SGETTYDHRNTFTLSCDGALRHKF-LDSNIKLSHVEKVGNNPASKGL---LTLDASTSWG
PQVSASVHLDLKKRQHLYIKDVKIDGQ---------------------------------
------GTNRITGRYEDGALSLTSTSELQGGTLKNTASLKYENYELTLKSDTSGKSDNLA
AHNKVDLTFSKQNALLRSEYAADYKSLKFFSLLSGSVNSHGVELNADVLGTDKTNAGAHK
ATLRIARDGISTSATTSLKYSPLFLENELNAELGLSGASVKLTANGRFREHSTKFTLDGK
AALTEVSLGSAYQAMILGVDTKNIFNFKVSGEELKLTNDLKGSYGEMTLDHTNSLHIAGL
SLEFSSKLDSIYSSDKFYKQNFNFQIQPFSLVTALNNDLKYSALGLTSSGKVRLEPLKLV
VDGNLKGSYQNNEIKHIFAVSYVDVS-ASCKAST---VARIQGTEFSHQLSAGLTGLAAS
VDTSTNYHSDSLRFGSAFHAAMAPFTLAVDAHANGNGKLAVWGEHTGQLYSKFLLKAEPL
ALTFSHDHKGSTNHRLLSRKSISTAVDHKLSVLLTPSQQTSTWKLKTQLNDNEYSQDFDA
YNTKDKIGVELRGRGLADLAALDSPIKVPLFLSEPVNVLEALQMKDAVQQPQEFTIAAVV
KYDKNQDVHTISLPFFRSLPEYLERNRLMLITVLEAMQKELKSIKIDQFVGKYRAGLGKL
PQQVNDYLNAFSWEGQVASAKEKLTAFAENYRITENDVQAALNNAKINLNEILSQLQTYV
IQFDQYIKDNYDLYDLKVAIAKIIDHIIENLKILDERYHIRVNLVRTIHNAHLFIENIDF
NKMGSSTASWIQNVDIQYQIRSQMQEKLQQVRTQLQNVDIQEIAAKLKQQVEAIDARVLL
NQLRTTIPFQRIKDIIEHIKYFVISLIEDFDVTEKINAFRAIAHELIKKYEVDQQIQVLL
DKSVQLAHQYKLKDTVQKLSNVLQQVDMKDCYEKLLVFVDDIIRQLKAFSFKHFLEELNQ
FLDILVKKLRSFDYHQFVDDTNHKIREVTQIINTEFQVLDLPQKAEAL-KLFVEDVRAML
CAFLEKLKDTKINVFVNSLQDALNSAHLVPIKAKFQETLEDLRDRIYQMDIQQELEHYLS
LAGQVYSTLVTYISDWWVVVAKNLTDFAEQYSVQAWAENVKALVEQGFTVPKIQLILGTL
PAFQISLRALQEASFQTPDFTVPLTDLRIPSVQINFKELKDIKIPPRFSTPEFTILNTFH
IPSFTIDFLEIKIKIIRTIDQMLSSEFQWPVPEVYLGDLKVEDVLPARLVLPDFHLPEIA
IPEFLIPNLNLTEFQVPDLHIPEFQLPPISYTAEIPAFGKLNSILKIQSPLFTLDAKADI
HNITT-SEHQAGTEASIAAKGESKFEVLNFDFQANAQLLNPKT--NPLFLKESMNFSSKY
LRMEHESEIRFSINAIEGKSDTLASLHTEKNTLELHNGVVVKIKDRLTLDSHTKYFHKLS
IPTLDFSSKADLSNAVKTLLEVGYITLTSSGAGSWKWACPNFSDEGTHESQINFTVEGLL
ASLGVANKINSKHLKVSQNLAYESGFLNFSKFEIRSDVESQHLGHSVLTAKGIALLGKGR
AEITADHNAHLNGKVIGTLKNSLFISAQPLEITASASNEGNLKVSFPLRLTGKIDFLNDY
ALLVSPAAQQTSWQASAGFNQYKYNQNFSATNNENSIDAHVSINGVANLDFLNIPFTIPE
MN--LPYTALTTPS-LKDFSIWEETGLKEFLKTTKQSFDLNVSVQYKKNKDKHSIAVPLG
AFYKFISQNVNSLDSYFEDVRDKALDFLTTSYNEVKIKLDEYKAERSLNKLPQTFPRPGY
TIPV---VNVEVTPFLVETLPSGHVIPKAVHTPSFTIPGSDFYVPSYTLVLP-SFELPDL
HIPRNLLQLSLPDFKELSTVNNIFIPAMGNITYDFSFKSSVITLNANAGLYNQSDLVAHF
LSSSSFVIDALQYKLEGTSRLTRKRGPKLATALSLS-NKFVEGSHDSTISITKKIMEASA
TTTAKVHVPVLRMNFKQELNGNTKSKPTVSSSIELTYDFNSPQLLSTVKGAIDHKLSLES
L-----TSYFSIESSTKGDIEGVVLS-REYSGAIANEASTYLSSKVTRSSVKLQGSSKVD
GIWNVELKENFAGEATLRRIYAMWEHSVKNHLQPHRHWSSHGEHTSKATLELFPGSVSAL
IQIRAREINSVFDIPHLDQEVALNANTKHQKFSWKSEVQAPYGTLQHNGQLSNDQKEARF
DIAGSLEGHLHFLKFVTLPVYDKSIWDLLKLDVTTSSRKRQYLRASTALVYTKNPKGYPF
SVPVQELADKFI--IPGLKLSDLSSDLATPTFRVPFTDLQIPAYTLDFNEIKIYKKLSTS
PFALNLPALPEVKFPQVDVLTKYSEPEESSVPFFEITVPEVQLTVSQFTLPKSLAVGSTV
LDLNEVASRVGDFELPTITVPEQTIEIPSIKFSVPAGVFIPFFGTLTAHFGVASPLYNAT
WNAGLKNKADHVETFLDSTCSSTLQFLEYDLNVVGTHRIEDGMLICKTEGMLAHHDFSAE
YKEDGKYKGLEDWEGELSLDISSPAFTELHLHYQENEK-SVSSSAASPAIGTVGLDMETE
GGRSFEFKL---YFQ-PQSSPGQQLNIFKTKWR--YRESDDKTQMKFNWEEEAAS-RLLN
SLRDNVPKATGAFHAYVDKYHREYTGLSLEDASVKLGRSLLDSAEGAYQRARRQIDKID-
-VGLQRAASSTTGAYQEWKEKAQDLYQGLL-ADEGQATSHRLKDK---------------
-------------LTRIHLPGIAGMYTRDELCTMVMKEIGKALSQAYSNIQSGLEKLLSY
VQDLVEKSELIKDLQIKFPFYSESHT---------LTEVILKSRKLLE----FLSKEAQE
VFTDLQSIKF-SETLTELQSLL-QRVFQEIEEEIKLLKETRLIHPINA----IHTVFNTY
IPLAFRVLKESLCLNLTKFN----ELVQNNLQMASEGLQQTHQYIKALREEYFDPSVVGW
TVKYYELEDKIIDLVMDLVIALHNFHSTYAAYVTSYVSQLSALAEQFVHKDVQEYLFILA
DADGKGKEKIAELSNTAQQVIKTLITATKEIVSDYQEK

PF12491 // ENSGT00590000083139_0_Domain_6 (4659, 4713)

FTSKLQEFPDQFSDYHEKFIAE
SQRVMDLFIQNYHMILSYITELLQKLQA-ATASGGNAYIKLAPGELTVTY----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------

------------------------------------------------QRP---------
----------REVLGRLSLLSPFLSEDEVLENVS-PGCSKDATR

PF01347 // ENSGT00590000083139_0_Domain_0 (105, 673)

FKHFRKYVYNYEAESS
SGVPGTADSRSATKINCKVELEVPQLCSFIMKTSQCTLKEVYGFNPEGKALLKKTKNSED
FAAAMSKYEL-RLVVPEGKQVFLYPEEDEPKHILNIKRGIISALLVPPETEEDNQVV---
FLDTVYGNCSTQLTVKTRKGNVATEITTDRN----LQQCDRFKPITTGVSPLALIKGLTR
PLSTLISSSQAC-QYTLDSRRKHVSEAVCKEQHLFLPFSYKNKYGMIAHITQTLKLEDTP
--KINSRFFGEG-AMKVGLAFESTKSTSLPKQ-AEAVLKTFQELKRLSASEQNAQRANLF
NKLVTELRGLSSEAITSLLPQLIEVSS--PITLQALVQCGQPQCYTHILQWLKHTHTNPL
LIDVVTYLVALIPEPSAQRLREIFNMAREQRSRASLYALSHVVKSYHE-THPTETQDL-L
DIADYLLEQIQNDCTGDEDYTNLILRVIGNMGQTMDRLTPTLKSSVLKCIQSTKPSVLIQ
KAAIQALRKMELKEEEQEVLLQTFLDGTSPGDKRLAAYLMLMRTPSQLDINKITQLLPQE
QDEQVKNFVASH

ENSGT00590000083139_0_Linker_0_3 (673, 709)

IANILNSEELYIQDLKTLVKEALKESQ-LPTVMDFR

PF09172 // ENSGT00590000083139_0_Domain_3 (709, 1025)

RFSRNYQLSKSV
SLPSLD-SASVKIEGNLIFDPNNYLPKESMLKTTLTVFGFASTDLFEIGLEGKGFEPTLE
ALFGKRGFFPDSANKALYWVNGQVPDHVSKVLMDHFGYTKDDKREQDMVNGIMLNVEKLI
KDLKSKGVPEARAYLRILGEELGFVRLRDLQYLGRLLLTSARTLQGIPQMIG-EAINKGS
KNDFFLHYIFMDNAFELPTGVGLQLQMSSSGIITPGTKAGVKLEVA-NMQAELVAKPSVS
VEFVTHMGMIIPDFARSGVQMNTNFFHESGLEARVALKAGQLKFIVPSPKRPVKLFSASN
TLHL

ENSGT00590000083139_0_Linker_3_5 (1025, 1042)

VSTT----KTEAIPPLI

PF06448 // ENSGT00590000083139_0_Domain_5 (1042, 1156)

ENRQSWSACKPFFTGLNYCTSV-AYSNASSTDSASYYPL
TGDTRLELELKPTGEVEQYSVSAIYELQREDRALVDTLKFVTQTEGVKQTEATVTFRYNR
QTVTLSSEVQIPDFD

ENSGT00590000083139_0_Linker_5_6 (1156, 4658)

VDLGTILRVNDESAEDKVSYKLTLDIQNKKITEVALMGRVSCDKK
EEGRIKGVISIPRLQAEARSEILTYWSPSKLLLQMDSS--ATAYGSTVSKRVAWRYDEEK
IEFEWNTGTNVDTKKLASNFPI----NLPDYPRSLHTYANSLLDHRVLQTDMTFRHMGSK
LIVATNTWLQKASESLPYAQTLQDHLSGLKELNLQQMGVPDLHIPENLFLKSDGRVKYTL
NKDSMKIEIPLPFGGKSSKDLNILESIRTPALQFKPVGFHLPAREFQVPTFTIPKSYQLP
VPLLGVLDLSTNVYSNLYNWSASYTGGNTSR-E--HFRLQARYHMKADSVIDLLSYSVQG
SGETTYDHRNAFTLSSDGALRHKF-LDSTIKFSHVEKVGKSPISKSL---LIFDASSAWG
PEMSASVHVDSKKKQHLYVKEVKVDGQFRVSSIHAKGIYDLSYQRDPITGQLSGESNLRF
NSTYLQGTNQMTGRYEDGTLSLTSTSDLQGGLIKNTASLKYENYELTLKSDTNGKSENFA
TSNKMDLTLSRQNALLRSEYQADYGSLRFFTLLSGLLNSHGLELNADILGTDRINSAAHK
ATLRIAQGRVSTSATTNLKYSPLVLENELNAELGLSGAHVKLTANGRFREDSAKFSLDGK
AALTEVSLGSAYQAMILGVDSKNIFNFKLSREGLKLSNDLMGSYGEMRLDHTNSLNIAGL
SLDFSSKLDNVYSSDKYYKQNFNLQLQPYSLVTTLNSDLKYNALDLTNTGKLRLEPLKLN
VGGNLKGAYQNNEIKHIYSISYAALS-ATYKADT---VAKVWGAEFSHRLSTDIAGLASA
IDISTNYNSDSLHFSNVFHSVMAPFTMGIDTHTNCNGKLALWGEHTGQLYSKFLLKAEPL
ALTFSHDYKGSTSHHLKSKKSISMALDHKVSALLTPAEQMGSWKLKTQLNDNEYSHDLEA
YNTKDKIGVELSGRALADLTLLDYPIKVPLVLSEPVNVIDALEMKDAVDKPQEFTVVAFV
KYDKNQDVHTISLPFFKTLPEYFERNRRMIITALEAIQKELKRVNIDQFVGKYRAAVGKL
PQQVNDYLNSLDWEKQVSNANEKLTAFTKNYRITANDLQIALDNAKINFNEKLSQLQTYV
IQFDQYIKDNYDLHDFKITVAKMIDQIIEKLKSLDEHYHICVSLVKTIHNLNSFIENIDF
STIGSSTASWIQNVDTKYQIRVHLQEKLQQLEAHVQNTDLQHFAGKLKQQVEAIDFKVLL
DQSRTTMTFARISNILEHVKYFVLSLITDFEVTEKINAFRATVYKLIEAYGLDQKIQVLM
DKSVQLAHQYKLKETVQKLSNVLQQIEIKDYFEKLVGLTDEAVKKLDALSFKKFMEEVNR
VLDMLIKKLKSFNYHQFVDETNNKVREVTQRINGKIRALELPQKAEAL-KLFVEDSKTLA
SEYLESLKDTKISSMTDWLQVALDLAPLVHMKAKFQETLEDVRDRMYRMDIQRELERYLS
LVGQVYNTLVTYLSDWWTLAAKNLTDFAEQYSIPDWAESVKALVKQGFTVPEIQTVFGVM
PAFEVSLRALQQATFQTPDFIVPLTDLRIQSVQINFKELKDIKIPSRFVTPEFTILNTFH
IPSFTIDLVEIKVKIIRIIDQMLSGELQWPVPEVYLRDLKVEDSPLARITLPDFHLPEIT
VPEFLIPNLNHSDFQVPDLHIPEFQLPHFSHTIEVPTFGKLYSVLKIQSPIFTLDANADI
QNVTASSANKADIAASIAAKGESKLEVLSFDFQANAQLSHPKT--NPLILKESMTFSSKY
LRTEHRSEMLFFENAIEGKSDIVASLHTEKNTLELSNGVIVKINNQLTLDSNTKYFHKLN
IPKLDFSSQADLRNEIKTLLKAGHVAWTSSGTGSWKWAYPKFSDEGTHESQINFTMKELT
TSFGLSNKINSKHLRVNQNLAYESGFLHFSKFEIQSQVESQHVGRSILTAQGTALFREGK
AEVTGNHDAHLNGKVIGTLKNSLSISAHSFEIAATANNEGNLKVSFPLKLTGKIDFLNNY
ALFLSSSVQQASWQASARFNQYKYNQNFSAGNNKNIIEAHVGINGEANLDFLNIPLTIPE
MT--LPYTTITTPP-LKDFSLWEKTGLKKVLKTTKQSFDLSAKAQYKKNKDQHSIANPLC
VFYEFVRQNMNSINSHFEKARNNAFSFLTKSYQEAKIKFDKYKAEESSNNLPRTFQIPGY
TIPV---INIEVSPFTVEMLTFGYVIPKAISTPSFTLPSSDLHVLSNTLVLP-SLELPVL
RVPEHLLKISLPDFKELCSVSNIFIPAMGNITYDFSFKSTVITLNTNAGLYNQSDIVAHL
LSASSSVIDALQYKLEGTSSLTRKRGLKLAMALSLN-NKYVEGNHDSTISLTKKNMEASV
TTTAKVQIPILRMNFTQLLNGNTKSKPTVSSSIELKYDFNSPKLYSTAKGEVYHKFSLES
L-----TSYFSIESSTIGNVKGSILS-REYSGTIAGETSTYLNSKGTRSLVTLQGASKVD
DIWKLELKETVGGEASLQRIYAIWEHNTKNHLQLEGLYSTGGEHTSIATLELSPWKISAL
VQVRASQHNSLLNIPYLSQEVSLNANTKNQKVSWKSEVQIHSGSLQNHVELSNDQEKAHL
DITGSLEGHLSFLKYIMLPVYEKNLWDILKLDVTTSTSRRQYLRASTALVYTKNPNGYPF
SVPVKVLDNEFI--VPGLKLNDLNSVLVTPTFQVPFTDLQVPSYKLDFSEIKIYKKLRTS
PFALNLPTLPKVNFPEIDVLTKYSQPEDSSVPLFDITVPEFQLTVSPFTLPKSISVGNVV
LDLNEVANKIANFELPTIIMPEQTIEIPSFKFSVPTGIFIPSFGTLTARFGVASPLYNAT
WSTGLKNKADHVETFLDSTCSSTIQFLEYDLNVVGTHKIENGSLVCKTKGTFAHRDFSAK
YEEDGKYKGLDKWEGEARLDITSPAFTDLHLSYQEDEK-SLSSSASSPAIGTVDMNLEED
V-EFLKWNL---YYR-PQSSPDKKFTIFKIEFR--DQESDEDLQIKVNWEDEAAS-RLLT
SLKDNVPKATEALYDYVDKYHREHTGLTLRDASSKVRRSLQNNADWAYQGAMRQIDKVE-
-MQLQREASDTIGIYQEWKEKAQTLYQESL-GQEDRVNFQRLKDKLFDSLVQITQKYHVT
VQYLIDSFIHFLKSGRFQLPGKPEMYTRDELFTMAMR--------VHANIHNRLEMLFVY
FQDLVENSELIKDLEIICPFDSKSYK---------LTDIILRCKKLLK----SLSQEVQE
AFNDLQSVKI-TEMLVDLRNIL-QRVFQEIEREIKRLKRKKFTELTND------------
IRYVFASLKKSLSFNFGKFN----ELVQNKLQEASQELQQIQKHIKALREEYFDPSVVGW
TVKYYELEEKIVNLIKNLVLALKDFHSKFTIGAADFISQLSSRVEQCMYGMVQEYLSILT
DTDGKGKEKIAELSATAQEIIKSRAVAMKKIISDYHQ

PF12491 // ENSGT00590000083139_0_Domain_6 (4658, 4717)

QFRYKLQDFSDQLCDYYEKFIAE
SKRLIDLSIQNYHMFLRYIMELLKKLQS-TTA--MSPYIKFAPGELTI------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------

---------------------------------------KPPPRRAAMAPWGT-------
----------LLLLLLL---------------LG-SSSSQDATRFKHLRKYVYSYEAESA
SSVAGTADSYSGTKISCKVCAPTPARLPLSPMGQSLQAGQVLSGSPESLGLHQPG-----
-----PGIDFRMAPLPTGSRAWAWPPGHRPLEGGRLSRAARLELLLPPTAESASGRTRRE
RMNEQMSECK---SINARLGSVLPEGSPRAPGRLGVGTERGSPSPGPRWTPLPNSPSQGG
PLS

PF01347 // ENSGT00590000083139_0_Domain_0 (304, 673)

RTLSSRQEC-VYTVDPRRKHVTEAVCREQHLFLPFSYKGQYGMKAHVTQILKLEDTP
--KINSRFFDEDAFPRKGLALESVEAAAPTKEGKEEVLQTLQELQKLAVSERGEHRAKLF
GRLVTGLRALSAEAVASLWPELLQVSS--PLALQALVQCGQPQCYAHILRWLKTEKADPL
LMDVAAYVMALVPRPSAQRLREIFEVAQERPNRVTLYALSHVVNKFQP-QTVAESEEL-K
AVANFLISRLGDECADDKEATYLTLRVIGNMGAALEEGSPRLKASVLKCIESPAASLPVQ
KAAIQALRKMELTEEVRGVLLRAFLDGASPEDKRLAAYLLLMRRPGREGLAQVLGALQAE
KNEQVRSFVASH

ENSGT00590000083139_0_Linker_0_3 (673, 709)

LANVLVSQDLSLQDLRSQVEAALQGSR-LPEATDFR

PF09172 // ENSGT00590000083139_0_Domain_3 (709, 1020)

RFSQNYQLSKAV
SIPSLS-PFSTKVEGNLLLDPHNYLPKEAMLKTTLSIFGFQPTDLFEVGLEGKAYGPTLE
ALFGKQGFFPDSATKALYWVDGRVPSSVSKVLEDHFGYSREEKRDQDMVNGLMLNFQKLL
KDLGSAEAPQAEAYLHLLGEELGYIRLEELKVLGARLIGMAKALGGLPQMVA-AALAKGS
KNDLFVHYIFMESSVELPTGAGLPLQLSTSGLVTPGLRAGMKLQVA-NMQAELVAKPSVA
VEFVTHVGVTIPDFAWSGVQMNSNLFHESGLEARLALTRGRLKLSVPAPKGPVKLFRART
GTNTKTQKLLSEASAFGGSLRRRAQDWLDHKVAHTDMTVRHMG-TKLIAVSEASCPYPP-
PGSRQASCGGQG------------------------------------------------
----FLGEGGLRD--LPLGPS---------------------------------------
---SLGLP-------------------PVKPFPGMSGGEGGVGLGAFI-HPPPW------
---AWDLAASKDTTVPASQAVP----R---ALG-LPRYPSHSP---PCKSSLTGLKLPFP
LLQATNTWFQKASQSLPYGETLQRKLQGLQEWE-----MPELQVPDTLFLKSDGRIRYTL
NKDHVDVEIPLLFGGTSLEQLQQGQVIRTPALDLQAIGLRVPSREFQVPPLSIPKSYPLR
VPLLGVLDFSTNVHSNLYNWSASWSLGNTTAPKAEHVSFQGRYHLKGDSALELLSFSAQG
FGESTYDHRNTFTYSWDESLHHKF-LDSNIKFNLVKKIGHNPASKGF---LTFNASSALG
PQASFSVHLDSKKKVHLYVKEMQAAGELTAASFHAKSTCALSYQRDPNTGHVGGESHLRV
DSSLLQASNQVTGSYRDGSLSITSTSDLQDGAVRNTASLTYENSQLTLKSDTSGKLSGLA
ATHKLDLTLTRQNALLRSEHQVDFQAVKVFTLLSGSLNSRGLELNADLLGTGQSSSAAHK
ATLRIGPDGVSTSATSNLKALPLMLENELNAALGPLGASLKLATNARYQEHSAKYSLDGK
VALTEVALGSVYQTTVLGVDGKSIFNFRLNKEGLTLANDMMGSYKESKLNHVSSLVVAGW
ALDFTSKMENVLSPNKFYQHNFNVQLQPYSLSATLNNNLKYNILDLANAGKLKLEPLKLS
LGGNMKGTYGGEEIKHIYTLTYADLS-ASYKTDT---LGRVGGAELTHRVSANLAGLASA
VDVNTAFNSESLRFNNVFHTVMEPFKLAMDAQTTGNGRLIWAGEHTGQLYSKLLLKAEPL
ALVFSHDYKASSGHQLRSKRSIETTLEHKVSTLFTPAEQSNTWKLKALANQNEYSHDLQT
YNSKDSVGMELRAKAVTDLAVIDSPLEVPYLSHEPINVIDAFDLRTQVGKPQEFSLTGSI
KYDKNLDVHVINLPFLETLPAFFEKIRGAVLAALQNLQQSLKSINIDHYVKRYRAALDKL
PQLVNEQLNNFNFEGQVINAKEKLITFMENYKITIDDLQILLDNAKIRLNEITSQLQTYL
IQFDQYIKDNYDLHKLKESLKELINEKIKELKVFEDNYQIRSYVMSAIQAIYEFVEKISV
NKVHA-----------MSRIRAEILEKLQHLNRQIQNIDFQHGADWLKKQVEAIDIRAYI
EFLRSLLPIRELNGVIEHLRDVVGNLLEDYEVTEKINAFLAKVHELTYKYEVHKRVQVLM
DKLIQLANQYKLRETTQKLTNSLKKLEIKAHFEKMRTLVDKAVRKAQTVRFKQLIDEANK
FLDLLIKKLRAFDYNQFVDEANKAIHELIQKINEEIRALELPQKIEAA-KSYASEVRATL
SDYLEKIQDTQLSVIADWFWEAMNSASVADIRGRFQEILEDTRDRLYTLDLQKEIQQRLQ
SLSQVYSTLVTYLVDWWMLISKELTDFAEQYRVQDWAESVKSLVEHGFTVPEIKTALGTL
PAFEVSLRALQEATFQTPDFVVPLTDLHIPSVQINMKKLKEIKVPSQFTTPEFSILNIFV
VPSFTIDLVEIKLKLIRTIDQMMSSEFRWPLPEVSLQNLKVKDTLLAALTLPDFHLPEVT
IPEIVIPKLSLNEFQLPDIQIPEFQLPRIPHTLAVPAFGKMSAALKITAPFFTLDASGNI
ENTTT-SERNPEIVASLVAEGQSAVDFLDFTLQADALLSAPEL--ERLILKESLKLTNKY
LKAEHNGETLFLQTSILGKASTLVGIYTSKNTVELDNSLSLKLQKQVTFDSNTKYSHKLN
LPQVDFSSQMELRHDLGTLLDAGHVTVTSAGRGTWKCAFPDFSDEGTHESLLKFTLEGPI
AFLDASNKINSKHVKVNQKLTSESSFLNFAKLEIQSEVESQHVGRSVLTVRGTGTIGEMK
GRLEGTHEASLTGRATGTLKNSLLFLVQPFEINTEMSNEGNMKVSFPLKLTGKIDFHNNY
ALALSCDFQQVSWQAGARFNQYRYSQNFSAGNDENSLEAHVSINGEANLDFLNIPLTIPE
MT--LPYTKVRMPP-LRDFSLWERTGLKNFLKTTKQSFDLSVNAQYKKN--SHLIPFPLG
AVYDVFGSKIHIFHRHFENIKWKTLDFLTKSYNTAKVRLDRHNVKSSLDKLPRTLEIPAY
YIPVLPVLNIEVDQFTAELPAFGFVTPWEVSTPSFTVPGIGFSMPSYTFVLP-SLEFPVL
HVPESFRDLSFPRVTIVRPPDYIPIPAVGNLTYDFSFKSSVITLSTNVGLHSQSDLVAHF
KSSSFSVIDALQYKLDGTTSLTRKRGLKLATALSL-NSKFVEGNHDSTLSLTKRNMEASV
TTTAKVQFPILRANFRQELTGNMKPKPTVSSSIHLKYNFTSARLHSSTKGAVEHKLTLES
FTSESPTPYLSVETAGKGSVSGSLLS-QKYSGAIAGEANSYFDTKGTRSSVKLEGASKVD
GVWNVEAKDNFAGEASLGHVYMVWEHSGKNHFQLRREFSTNGEQKTKVTLELAPWTASGV
IQLQASQPSSLFRKASLNQTATLAASLKNQRVTWKGEGHVQTVSLGHNVQLTNDPAEIRL
NAAGSLEGHLAFLKDALLPVYESSLWDILKLDVTTRPDKKQYLHLSSALVYTKSPTGRWL
SIPVQETAEEFL--IPRLGLG--PSS-------------------SERSSLRVPKKTSVA
PFAFSLPSLPQVKFPRVEVSTEYSGPEGAALPFFGVTVPEFHVTLSPFTLPKKFSLAGAV
LDLNEVANKIADFDLPNVAMAEQSVRVPALTFWLPAGIFVPHFGALAGDFRAASPVYNTS
WSINVQRKE-GVELSLEATCSSTVQALEYDLTYEAKYSKAEDVFVQKDKGTFSHRDLSVE
YEKTSKVQNLELLEDVKTLKITSPTFTDVLMNYREARN-SLSLTVSSPPIGTLSLERQQS
P-DALRSKM---YYH-PKEWAQCPGRLPRAR----------------AF-----------
---GPGPRTA----------------SETGAVDLLSPGILVKPSAAGWGGG-GSLD----
--GAPQAVDKAASTYRQWGDSVQRLYQAE------EADPQLLKDRVLEGALRLTQEYRKK
TRLLLDSALEFLKVSRFQLPGKAESYTGDELCSAVLRRAGRALAQAYSRVHQTLEALVSH
VRDLG----------EDV-----------------AIQSLVDFGESLKSFSESI----QC
KLNELQEATF-SNLLISLQSFT-DNVFQEVERNIKILKEKTFSCLKDEFQIAVQ-A----
IFDFIPPILMEVTEGLKSLH----SLVLTQFQKIS---GNFHNSIKTLREEYLDPNIMGW
TARYHEIEDKLVSLARRILAALKDFQSQAFEGLLALVSRLTKEVESFTNTSVQKYLDLLL
DVDGKGKERIGKAFAAAREKIGSWAAEAKGKAAELRDRLMRWLQAAYNHVAEAVRRATEQ
AGNLPGLLVRGYQALLEYVAELLQSLQW-TTA----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------

-----------------------------------------------MGPPRPALL----
AL---PALL-LLLAGARAEKE----M---LENVS-PVCPRDTTR

PF01347 // ENSGT00590000083139_0_Domain_0 (105, 673)

FKHLRKYTYNYEAESS
SGVPGTADSRSATRINCKVELEVPQLCSFILKTSQCTLKEVYGFNPEGRALLKKTKNSEE
FAAAMSRYEL-KLVIPEGKQVFLYPEKDEPTHILNIKRGIISALLVPPETEETKQVL---
FLDTVYGNCSTHFTVKTRKGNVATEISTERD----LGQCDRFKPIRTGVSPLALIKGMTH
PLSTLISSSQSC-QYTLDAKRKHVAE---KEQHLFLPFSYKNMYGMGVQVTQTLKLEDTP
--KINSRFFGEG-TKKVGLAFESTKSTSPPKQ-AEAVLKTLQELKKLTISEQNIQRANLF
HKLVTELRGLSDEAVTSLLPQLIEVSS--PITLQALVQCGQPQCSTHILQWLKRVHANPL
LIDVVTYLVALIPEPSAQQLREIFNMAREQRSRATLYALSHAVNNYHK-TNPTGTQEL-L
DIANYLMEQIQDDCTGDEDYTYLILRVIGNMGQTMEQLTPELKSSILKCVQSTKPSLMIQ
KAAIQALRKMEPKDEDQEVLLQTFLDDASPGDKRLAAYLMLMRSPSQADINKIVQLLPRE
QNEQVKNFVASH

ENSGT00590000083139_0_Linker_0_3 (673, 709)

IANILNSEELDIQDLKKLAKEALKESQ-LPTVMDFR

PF09172 // ENSGT00590000083139_0_Domain_3 (709, 1017)

KFSRNYRFSKSV
SLPSLD-PASAKIEGNLIFDPNNYLPKETMLKTTLTAFGFASADLFEIGLEGKGFEPTLE
ALFGKQGFFPDSVNKALYWVNGQVPDGVSKVLVDHFGYTKEDKREQDMVNGMMFTVQKLI
EDLKSKEVPEARAYLRILGEELGFARLHDLQLLGKLLLMGARTLQGIPQMIG-EVIRKGS
KNDFFLHYIFIENAFELPTGAGLQLQISSSGVTAPGIKAGVKLEVA-NMQAELVAKPSVS
VEFVTNMGIIIPDFARSGVQMNTNLFHESGLEARVALKAGQLKFIIPSPKRPVKLL

ENSGT00590000083139_0_Linker_3_5 (1017, 1044)

SGSN
TLHLVSTT----KTEVIPPLIEN

PF06448 // ENSGT00590000083139_0_Domain_5 (1044, 1156)

RQSLSVCKQLFTGLNYCTSS-AYSNASSTDSAPYYPL
TGDTRLELELRPTGEVEQYSVSATYELQREDRALVDTLKFVTQAEGVKQTEATMTFKYNR
QSMTLSSEVQIPDFD

ENSGT00590000083139_0_Linker_5_6 (1156, 4658)

VDLGTILRVNDESTEGRKSYRLTLDIQNKKITEVTLMGHLSCDTK
EEGKIKGVISVPRLQAEARSEIIAHWSPAKLLLQMDSS--ATAYGSTVSKRVAWHYDEEK
IEFEWNTGTNVDTKKMTSNFPV----DLSEYPRSLHMYADRLLDHRVPQTDMTFRHVGSK
LIVAMNSWLQKASGNLPYTQTLQDHLNSLKELNLQNMGLPDFHIPENLFLKSDGRVKYTL
NKNSLKVEIPLPFGGKSSRDLKMLETVRTPALHFTSVDFHLPSREFQVPTFTIPKLYQLQ
VPLLGVLDLSANVYSNLYNWSASYTGGNTST-D--HFSLQARYHMKADSVVDLLSYNVQG
SGEATYDHKNTFTLSCGGSLRHKF-LDSNIKFSHVEKLGNNPVSKGL---LIFDASSSWG
PQMSASVHLDSKKEQHLFVKEVKIDGQFRVSSFYAKGTYGLSCQRDPNTGRLNGESNLRF
NSSYLQGTNQITGRYEDGTLSLISTSDLQSGIIKNTASLKYENYELTLKSDTNGKYENFA
TSNKMDMTFSKQNALLRSEYQADYESLRFFSLLSGSLNSHGLELNADILGTDKINSGAHK
ATLRIGQDGVSTSATTNLKYSPLVLENELNAEIGLPGASMKLTTNGRFREHNAKFSLDGK
AALTELSLGSAYQAMILGVDSKNIFNFKISQEGLKLSNDMMGSYAEMKFDHTNSLNIAGL
SLDFSSKLDNIYSSDKFYKQTFNLQLQPYSLVTTLNNDLKYNALDLTNNGKLRLEPLKLH
MAGNLKGAYQNNEIKHIYTISSAALS-ASYKADT---VAKVQGVEFSHRLNTDIAGLASA
IDISTNYNSDSLHFSNVFHSVMAPFTMTIDTHTNGNGKLALWGEHTGQLYSKFLLKAEPL
AFTFSHDYKGSTSHHLMSRKSISTSLEHKVSALLTPAEQTGTWKLKTQFNNNEYSQDLDA
YNTKDKIGVELSGRALADLTLLDYPIEVPLLLSEPVNVIDALEMRDAVEKPQEFTIVAFV
KYDKNQDVHTINLPFFETLQEYFERNQRTIIVVLENMQRHLKRTNIDQFVRKYRAALGKL
PQQANDYLNSFNWERQVSRAKEKLTALTKKYRITENDIQIALDDAKINFNEKLSQLQTYM
IQFDQYIKDNYDLHDLKIAIANIIDQIIEKLKSLDEHYHIRVNLVKTIHDLHLFIENIDF
NKIGSSTASWIQNVDTKYQIRIRIQEKLQQLKRHIQNIDIQHLAGKLKQHVEAIDVRVLL
DQLGTTISFERINDVLEYVKHFVINLIGDFEVAEKINAFRAKVHELIERYEVDQQIQVLM
DKLVELAHQYKLKETIQKLSNVLQQVKIKDYFEKLVGFIDDAVKHLDELSFKTFIEDVNK
FLDMLIKKLKSFDYHQFVDETNNKIRELTQRLNGEIQALELPQKAEAL-KLFLQETKATV
AMYLESLQDTKITLIIDWLQDALSSASLAHMKAKFRETLEDTRDRIYQMDIEQELQRYLS
LVGQVYSTLVTYISDWWTLAAKNLTDFAEQYSIQDWAKHVKALVEQGFTVPEIKTILGTM
PAFEVSLQALQKATFQTPDFIVPLTDLRIPSVQINFKELKDIKIPSRFSTPEFTILNTFH
IPSFTIDFVEIKVKIIRTIDQMLNSELQWPVPEVYLRDLKVEDIPLARITLPDFHLPEIA
IPEFVIPNLNLNDFQVPDLHIPEFQLPHISHTIEVPTFGKLYSILKIQSPLFTLDANADI
GNGTT-SANEAGIAASITAKGESKLEVLNFDFQANAQLSNPKI--NPLALKEFVKFSSKY
LRTEHGSEMLFFGNAIEGKSNTVASLHTEKNTLELSNEVIVKINNQLTLDSNTKYFHKLN
IPKLDFSSQADLRNEIKTLLEAGHIAWTSSGKGSWKWACPRFSDEGTHESQISFTIEGPL
TSFGLSNKINSKHLRVNQNLVYESGSLNFSKLEIQSQVDSQHVGHSVLTAKGTALFGEGK
AEFTGRHDAHLNGKVIGTLKNSLFFSAQPFEITTSTNNEGNLKVSFPLRLTGKIDFLNNY
ALFLSPSAQQASWQVSTRFNQYKYNQNFSAGNNKNIMEAHIGINGEANLDFLNIPLTIPE
MP--LPYTTITTPP-LKDFSLWEKTGLKEFLKTTKQSFDLSVKAQYKKNIHRHSITNPLA
VLYEFTSQNIKSFDKHFEKARNNALGFVTKSYNDAKIKFDKYKAEKSHDELPRTFQIPGY
TVPV---VNVEVSPFTVEMSAFGYGIPKAVSMPSFTILGSNIRVPSYTLILP-SLELPVL
QVPRNL-KLSLPDFKELCTISHIFIPAMGNITFDFSFKSSVISLNTNAEVFNQSDIVAHL
LSSSSSVIEVLQYKLEGTTRLTRKRGLKLATALSLS-NKFVEGSHNSTVSLTKKNMEASV
ATTAKVQIPILRINFRQELNGNTKSKPTVSSSMEFKYDFNSSMLYSTAKGAVDHKLILES
L-----TSYFSIESSTKGDVKGSVLS-RDYSGTIASEANTYLNSKSTRSSVKLQGTSKID
DIWNLDIKENFAGEATLQRIYSLWEHSMKNHLKLEGLFFTNGEHTSKATLELSPWEMSAF
VQVHASQPNSFLDIPHLGQEVALNANTKNQKIRWKNEVRVHSGSFQNHVELSNDQEKAHL
DIAGSLEGHLRFLKNIILPVYGKSLWDFLKLDVTTSIGRRQHLRVSTAFVYTKNPDGYSF
SIPVKVLADVFI--IPGLKLNDLNSVLVMPTFHVPFTDLQVPSYKLDFREIKIYKKLRTS
SFALNLPALPEVKFPEVDVLTKYSQPEDSLIPFFEITVPESQLTVSQFTLPKSVSVGSAV
LDLNAVANKIADFELPTIIMPEQTIEIPSIKFSVPAGIFIPSFQALTARFEVDSPLYNAT
WSASLKNKADHVETVLDSTCSSTMQFLEYKLNVVGTHRIEDGMLASKTKGTFAHHDFSAE
YEEDGKYKGLREWERKVHLDIKSPAFTDLHLRYQKDKK-GVSTSAASPAIGTMGMDV---
--DFSKWNI---YYS-PQSSPDKKLTIFKTELR--FRESDEEIQIKVNWEEEAAS-GLLT
SLKDNVPKATGALYDYVNKYHWEHTGLTLREASSKLRRNLQNNAEWVYQGAIRQIDDID-
-LRFQKAASGTTGTYQEWKDKAQNLYQELL-TQEGQTSFQGLKDKVFDGLVRVTQEFHTK
VKHLIDSLIDFLNFPRFQFPGKPGTYTGEELCTMFLREVGMVLSQVCLKVHNGSEILFSY
FQDLV----------ITLPFELRRHK---------LIDVISMCRERLK----VLSEEAQE
VFKDIQSLKT-TEVLRNLQDVL-QFIFQLIEDNIKELKEMKFTHLINYIQDEINTIFNDY
IPYVFKLLKENLCLNLHKFN----EFIQNELQGASQELQQIHQYIMALREEYFDPSVVGW
TVKYYELEEKIVRLIKNLLVALKDFHSEYIVSASDFTSQLSSQVEQFLHRNIQEYLSILT
DPDGKGKEKIAELSTTAQEIIKGQAIAMKEIISDYHQ

PF12491 // ENSGT00590000083139_0_Domain_6 (4658, 4716)

QFRYKLQDFSDQLSDYYEKFIAE
SKRLIDLSIQNYHTFLIYIMELLKKLQS-TTV--MNPYVKLAPGELTIIL----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------

-----------------------------------------------MGPPRPALL----
AL---PALL-LLLAGARAEKE----M---LENVS-PVCPRDTTR

PF01347 // ENSGT00590000083139_0_Domain_0 (105, 673)

FKHLRKYTYNYEAESS
SGVPGTADSRSATRINCKVELEVPQLCSFILKTSQCTLKEVYGFNPEGRALLKKTKNSEE
FAAAMSRYEL-KLVIPEGKQVFLYPEKDEPTHILNIKRGIISALLVPPETEETKQVL---
FLDTVYGNCSTHFTVKTRKGNVATEISTERD----LGQCDRFKPIRTGVSPLALIKGMTH
PLSTLISSSQSC-QYTLDAKRKHVAEAICKEQHLFLPFSYKNMYGMGVQVTQTLKLEDTP
--KINSRFFGEG-TKKVGLAFESTKSTSPPKQ-AEAVLKTLQELKKLTISEQNIQRANLF
HKLVTELRGLSEEAVTSLLPQLIEVSS--PITLQALVQCGQPQCSTHILQWLKRVHANPL
LIDVVTYLVALIPEPSAQQLREIFNMAREQRSRATLYALSHAVNNYHE-TNPTGTQEL-L
DIANYLMEQIQDDCTGDEDYTYLILRVIGNMGQTMEQVTPELKSSILKCVQSTKPSLMIQ
KAAIQALRKMEPKDEDQEVLLQTFLDDASPGDKRLAAYLMLMRSPSQADINKIVQLLPRE
QNEQVKNFVASH

ENSGT00590000083139_0_Linker_0_3 (673, 709)

IANILNSEELDIQDLKKLVKEALKESQ-LPTVMDFR

PF09172 // ENSGT00590000083139_0_Domain_3 (709, 1017)

KFSRNYRLYKSV
SLPSLD-PASAKIEGNLIFDPNNYLPKETMLKTTLTAFGFASADLFEIGLEGKGFEPTLE
ALFGKQGFFPDSVNKALYWVNGQVPDGVSKVLVDHFGYTKEDKREQDMVNGMMFTVQKLI
EDLKSKEVPEARAYLRILGEELGFARLHDLQLLGKLLLTGARTLQGIPQMIG-EVIRKGS
KNDFFLHYIFIENAFELPTGAGLQLQISSSGVTAPGIKAGVKLEVA-NMQAELVAKPSVS
VEFVTNMGIIIPDFARSGVQMNTNFFHESGLEAHVALKAGQLKFIIPSPKKPVKLL

ENSGT00590000083139_0_Linker_3_5 (1017, 1044)

SGSN
TLHLVSTT----KTEVIPPLIEN

PF06448 // ENSGT00590000083139_0_Domain_5 (1044, 1156)

RQSLSVCKQLFTGLNYCTSS-AYSNASSTDSAPYYPL
TGDTRLELELRPTGEVEQYSVSATYELQREDRALVDTLKFVTQAEGVKQTEATMTFKYNR
QSMTLSSEVQIPDFD

ENSGT00590000083139_0_Linker_5_6 (1156, 4658)

VDLGTILRVNDESTEGRKSYRLTLDIQNKKITEVTLMGHLSCDTK
EEGKIKGVISVPRLQAEARSEIIAHWSPAKLLLQMDSS--ATAYGSTVSKRVAWHYDEEK
IEFEWNTGTNVDTKKMTSNFPV----DLSEYPRSLHMYADRLLDHRVPQTDMTFRHVGSK
LIVAMNSWLQKASGSLPYTQTLQDHLNSLKELYLQNMGLPDFHIPENLFLKSDGRVKYTL
NKNSLKVEIPLPFGGKSSRDLKMLETVRTPALHFTSVDFHLPSREFQVPTFTIPKLYQLQ
VPLLGVLDLSANVYSNLYNWSASYTGGNTST-D--HFSLQARYHMKADSVVDLLSYNVQG
SGEATYDHKNTLTLSCGGSLRHKF-LDSNIKFSHVEKLGNNPVSKGL---LIFDASSSWG
PQMSASVHLDSKKEQHLFVKEVKIDGQFRVSSFYAKGTYGLSCQRDPNTGRLNGESNLRF
NSSYLQGTNQITGRYEDGTLSLISTSDLQSGIIKNTASLKYENYELTLKSDTNGKYENFA
TSNKMDMTFSKQNALLRSEYQADYESLRFFSLLSGSLNSHGLELNADILGTDKINSGAHK
ATLRIGQDGVSTSATTNLKYSPLVLENELNAEIGLSGASMKLTTNGRFREHNAKFSLDGK
AALTELSLGSAYQAMILGVDSKNIFNFKISQEGLKLSNDMMGSYAEMKFDHTNSLNIAGL
SLDFSSKLDNIYSSDKFYKQTFNLQLQPYSLVTTLNNDLKYNALDLTNNGKLRLEPLKLH
MAGNLKGAYQNNEIKHIYTISSAALS-ASYKADT---VAKVQGVEFSHRLNTDIAGLASA
IDISTNYNSDSLHFSNVFHSVMAPFTMTIDTHTNGNGKLALWGEHTGQLYSKFLLKAEPL
AFTFSHDYKGSTSHHLMSRKSISTSLEHKVSALLTPAEQTGTWKLKTQFNNNEYSQDLDA
YNTKDKIGVELSGRALADLTLLDYPIEVPLLLSEPVNVIDALEMRDAVEKPQEFTIVAFV
KYDKNQDVHTINLPFFETLQEYFERNQRTIIVVLENMQRHLKRINIDQFVRKYRAALGKL
PQQANDYLNSFNWERQVSRAKEKLTALTKKYRITENDIQIALDDAKINFNEKLSQLQTYM
IQFDQYIKDNYDLHDLKIAIANIIDQIIEKLKSLDEHYHIRVNLVKTIHDLHLFIENIDF
NKIESSTASWIQNVDTKYQIRIRIQEKLQQLKRHIQNIDIQHLAGKLKQHIEAINVRVLL
DQLGTTISFERINDVLEYVKHFVINLIGDFEVAEKINAFRAKVHELIERYEVDQQIQVLM
DKLVELAHQYKLKETIQKLSNVLQQVKIKDYFEKLVGFIDDAVKQLDELSFKTFIEDVNK
FLDMLIKKLKSFDYHQFVDETNNKIRELTQRLNGEIQALELPQKAEAL-KLFLQETKATV
AMYLESLQDTKITLIIDWLQDALSSASLAHMKAKFRETLEDTRDRIYQMDIEQELQRYLS
LVGQVYSTLVTFISDWWTLAAKNLTDFAEQYSIQDWAKHVKALVEQGFTVPEIKTILGTM
PAFEVSLQALQKATFQTPDFIVPLTDLRIPSVQINFKELKDIKIPSRFSTPEFTILNTFH
IPSFTIDFVEIKVKIIRTIDQMLNSELQWPVPEVYLRDLKVEDIPLARITLPDFHLPEIA
IPEFVIPNLNLNDFQVPDLHIPEFQLPHISHTIEVPTFGKLYSILKIQSPLFTLDANADI
GNGTT-SANEAGIAASITAKGESKLEVLNFDFQANAQLSNPKI--NPLALKEFVKFSSKY
LRTEHGSEMLFFGNAIEGKSNTVASLHTEKNTLELSNEVIVKINNQLTLDSNTKYFHKLN
IPKLDFSSQADLRNEIKTLLEAGHIAWTSSGKGSWKWACPRFSDEGTHESQISFTIEGPL
TSFGLSNKINSKHLRVNQNLVYESGSLNFSKLEIQSQVDSQHVGHSVLTAKGTALFGEGK
AEFTGRHDAHLNGKVIGTLKNSLFFSAQPFEITTSTNNEGNLKVSFPLRLTGKIDFLNNY
ALFLSPSAQQASWQVSTRFNQYKYNQNFSAGNNKNIMEAHIGINGEANLDFLNIPLTIPE
MP--LPYTTITTPP-LKDFSLWEKTGLKEFLKTTKQSFDLSVKAQYKKNTHRHSITNPLA
VLYEFTSQNIKSFDKHFEKARNNALGFVTKSYNDAKIKFDKYKAEKSHDELPRTFQIPGY
TVPV---VNVEVSPFTVEMSAFGYGIPKAVSMPSFTILGSNIRVPSYTLILP-SLELPVL
QVPRNL-KLSLPDFKELCTISHIFIPAMGNITFDFSFKSSVISLNTNAEVFNQSDIVAHL
LSSSSSVIDVLQYKLEGTTRLTRKRGLKLATALSLS-NKFVEGSHNSTVSLTKKNMEASV
ATTAKVQIPILRINFKQELNGNTKSKPTVSSSMEFKYDFNSSMLYSTAKGAVDHKLILES
L-----TSYFSIESSTKGDVKGSVLS-RDYSGTIASEANTYLNSKSTRSSVKLQGTSKID
DIWNLDVKENFAGEATLQRIYSLWEHSMKNHLKLEGLFFTNGEHTSKATLELSPWEMSAF
VQVHASQPNSFLDIPHLGQEVALNANTKNQKIRWKNEVRVHSGSFQNHVELSNDQEKAHL
DIAGSLEGHLRFLKNIILPVYGKSLWDFLKLDVTTSIGRRQHLRVSTAFVYTKNPNGYSF
SIPVKVLADEFI--IPGLKLNDLNSVLVMPTFHVPFTDLQVPSYKLDFREIKIYKKLRTS
SFALNLPALPEVKFPEVDVLTKYSQPEDSLIPFFEITVPESQLNVSQFTLPKSVSVGSAV
LDLNVVANKIADFELPTIIMPEQTIEIPSIKFSVPAGIFIPSFQALTARFEVDSPLYNAT
WRASLKNKADHVETVLDSTCSSTMQFLEYKLNVVGTHRIEDGMLASKTKGTFAHHDFSAE
YEEDGKYKGLREWERKVHLDIKSPAFTDLHLRYQKDKK-GISTSAASPAIGTMGMDV---
--DFSKWNI---YYS-PQSSPDKKLTIFKTELR--FRESDEEIQIKVNWEEEAAS-GLLT
SLKDNVPKATGALYDYVNKYHWEHTGLTLREASSKLRRNLQNNAEWVYQGAIRQIDDID-
-LRFQKAASGTTGTYQKWKDKAQNLYQELL-TQEGQTSFQGLKDKVFDGLVRVTQEFHTK
VKHLIDSLIDFLNFPRFQFPGKPGTYTGEELCTMFIREVGMVLSQVCLKVHNGSEILFSY
FQDLV----------ITLPFELRRHK---------LIDVISMCREWLK----VLSEEAQE
VFKDIQSLKT-TEVLRNLQDIL-QFIFQLIEGNIKELKEMKFTHLINYIQDGINTIFNDY
IPYVFKLLKENLCLNLHKFN----EFIQNELQGASQELQQIHQYIMALREEYFDPSVVGW
TVKYYELEEKIVRLIKNLLVALKDFHSEYIVSASDFTSQLSSQVEQFLHRNIQEYLSILT
DPDGKGKEKIAELSTTAQEIIKSQAIAMKEIISDYHQ

PF12491 // ENSGT00590000083139_0_Domain_6 (4658, 4716)

QFRYKLQDFSDQLSDYYEKFIAE
SKRLIDLSIQNYHTFLIYIMELLKKLQS-TTV--MNSYVKLAPGELTIIL----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------

------------------------------------------------------------
----------------------------------------DATRFKL-QKYVYY-EPEG-
TSAPS----------T

PF01347 // ENSGT00590000083139_0_Domain_0 (137, 363)

ADVELEVPQLCSFILRLSQCTLKEVSGFSAEGRALLKKTKNSEE
FAAAMSRHEL-RLAFPGGKQVVLYPEKDEPKQILNIKRGIISALLVPPETEEARQVL---
FLDTVYGNCSSDVTVKARKGTVATEMAIERD----LERCEGFRPLSTGVSPLAFIQGLSH
PLSTLTDSHQAC-QYTLDPKRKHVSEARCQEQHLFLPFSYRNKYGVKTQVTQTLTLEDTP
--

ENSGT00590000083139_0_Linker_0_2 (363, 616)

KLNSRFFDEX-XXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXX-X
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXX

PF01347 // ENSGT00590000083139_0_Domain_2 (616, 674)

IRKVLLQTFLHEAAPTEKRLAAYLVLMSGPSQSDISTVTQLLPRE
QNQQVKNFVASHM

ENSGT00590000083139_0_Linker_2_3 (674, 709)

ANILNSEDLYVQDLKTVVEGALKESQ-LPTLMDFN

PF09172 // ENSGT00590000083139_0_Domain_3 (709, 1025)

TFSRNYQLSKSV
SLASLD-PFSGKIEGNLIFDPNSYLPKESMLKTTLTVLGLAPLDLIEIGLEGKGFEPTLE
ALFGKQGFFPNSVNKALYWVDGQVPDDISSVLMDHFGYTKDDKREQDMAKGIMFSIQNLL
KDLKSKEFPEARAYLQVLGEELGFVRLQDLKLLGRLLMNGVQSLRGIPQMIE-DVLKRGS
KNGLFLHYIFMDNAFQLPTGLGLPVHVSSSGILTPGLKAGLKLELL-NMDMELVAQPSVS
VEFVTTMGLVIPDFARSGVQMNTNFFHETGLEARMTLKNRQLKFTLPLPKKPIKLFSFSN
TIHL

ENSGT00590000083139_0_Linker_3_5 (1025, 1041)

VTTS----RTEVIPSL

PF06448 // ENSGT00590000083139_0_Domain_5 (1041, 1157)

VFDRQSWSTCRPFLPGLNYCIMS-DYSNATSTDSGFYSPL
LGETRFVLELRPTGAVRQYSASAAYDILREGEALVDTLKFVTQAEDLQGTTMTMAFRYNR
QRKVFSTELQVPPLDVDLSTVLRVSDESAEGKKSYKLTLDIQNKKITEVTLTGHISCDGK
KGGKIRGVISIPRLQAEARSEIHTVWSPTKLLLHMDSS--ATAYGSTISKKVAWHYDEEK
MEFEWNTGTNVNTKKVASNLPL----DLSSYPKRLHEYTSSLLDNRIPQTDMTFRHMGSK
LVAATNTWLQHVYRNFPSTEKVQDHLSGLKELYLQEMRIPEFHMPENLFLKSDGRVKYIL
NKNSLKIEIPLPFGGKSSKDLKMWDTVRTPALNFRSVGISLPSREFQMPTFTIPKLYELH
VPLLGMLDVSTNVYSNLYNWSALYTGGNSSK-D--HLSLQALYQVKADSVVDLLSYHVQG
SGETTYDHRNTFTVSCDGILHHKL-LNSNLKFSHVAKTGNNPASKGL---LTFDASSPWG
PQMSASVHLDSRKKQHLYVKEVRMDGQFKVSSFYSNGVYSLSYQRDPMIGQLHGESSLRF
NSSYIQGTNQVTGMYEDGNISLISASDLQGGL-ENTASLKYENAKLTL-SDTSWQYEDFV
TSSKVDLSFSKHSALLRSEYQADYRSLRLFSLMSGSLTAQGLELNADMLGTDKVNSGAHK
ATLKIGRDGISTSATSNLKFSPLVLENELNAALDLSGLLMRLTSNGRYREHNAKFSLDGK
AALTELSVGSAYQATILGADSKNVFNFKLNQDGLKLSNDLLGSYAEMKFDYTNNLNIAGL
SLDFSSKLDSIYSSDKFYKQLLSLQLQPYFLVTTLNNDLKFNALGLTNHGKLRLEPLKLH
EGGSVKGVYQDDEIKXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXLNTIAGLATA
FDMSTNYNSDSLHFGNVFHAAVAPFTVTVDAHTNGNGKLILWGDHTGQLYNKFLLKAEPL
TFTLTHDYRGSTNHHLKSKRSLSTALNHKANVLLTPAEQTGSWKIKTQWNKNEYYQDFDA
YNTKDKVGVEFSGRALADLTMLDGPISLPFLSSKPINVIDAFEMRETIDQPQEFAVAASV
KYDKTQDVHTINLPFLKLLPEYFEKNRALVITALEAIQKELKHVNIDQFMRKYRAALDGF
PQQLNDYLDASNWERQVASAKEKLKAFTKNYKITENDLKMALDNAKINLNEKLSQLQTYV
IQFDQYIKDSNDLNYVKIVITKIIERIIEKLQILDEH----ANLVKALQDLSLLIEKIDF
HRINSRIASWVENMDNNYQIRIQIQEKLQQIKTQIEIIDTQHLAGKLKQQLETFDVKVLW
DQLRATIPFQKIKEIIEHVEYRVISLIEGLKVTEKVNTFIVIIHKLIELYEIDQHTQVLV
DKLVQLANQYKLKETVEKISNALRHVEMKVHFEKLLSLIDDATKKLKTLSFETFIEEVNR
FLNMLVKKLRSFDYHQFVDTTNNKIHEVTRRINSEIQALELPQKAKAL-KLFVDSIKVMV
SDIWEKVKNIKITLFFDWLQDPLSSASLTYMREKXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXKLN
IPTFDFSSQADLRNDIKTLLEVGHVTLSSSGTGSWKWAHPKYSDEGTHESQINFAMEGPI
TSFELTNKVNSKHLKLNQNVGFKSGFLNFSKFEIQSQVESQYLGHSILTVKGIALLGEKK
AEITGSHNAYLSGKVSGTLKNSLFFLIQPFEITASSNNEGNLKVVFPLKLTGKIDFLNNY
ALLLSPSAQQASWQAGARFNQYKYSHNFSAGNNENSMEAHVGMNGEANLDFLNIPLTIPE
MA--LPFTTLTTPQ-VKEFSLWEEAGLKKVLKTTKQSFDLNVKIQYMKNKNQHSISVPLE
SVYVFIHRNINDFMGKFEKARDKTLGFLAKSYNEARFKFN-----KSLNEQPRTFQIPGY
TIPV---INLEASPFTVEMLPFDYMIPKEIITPNFTIPGSDFSVSSYNLALP-FLELPDL
QIPGYLPQFSLPEFKAMSF----PVPALGNITCDFSFKSSLITLNTNAGLYNQSDLVAHF
VSSSSSVFSALQYKLEGTSSLTRKRGLKVATALSLN-NKFVEGKHDSTISLTKKNMEASV
TTVAKVHTPVLRISFKQQLNGNTKSNPTILSSVDFEYDFNFHRVYTTATGEVNHKLSL-S
L-----TSYLAIESSTKGXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMGTHKFENGAMVCKTRGTFAHPDFSAE
YQEDGRYDKLWDWRGESRLDILSPTFTDIHLHYQADEN-TLSSLVVSPALGTVAMQLEDK
D-SIFKVNV---YYR-PEXXXXXXXXXXXXXXXXXXXXX---XXXXXXXXXXXXXXXXXX
XXXXXXXKATEVLFIYPNNSPQ-SPGLILREVSK--LRGSRTSAERVYQGAKWQIDEVQ-
-SSIQRTVRETKRNYQQWQDKAQNLYQELL-AQEGGVNFQRFQTQVFDGLIGVTRESNKT
VTHLIDSFVEFLRFNKLRLPGRIGVYTGDELCNMVLREVGKVLLQVHSAILDGLEMVVSY
SQDLVP----------TIKFALKSHG---------VIDPLLEWVDPLNLF--ALSEIIKQ
PLNDLLFINT-TETLHDLQEFF-QFIFQDVEIRLLYVREKKLSYLINASLQEISILFRQY
ALYAFEFLRENIYLTFGRLN----ELIHIRLQEVSQQL----QIIKDNCKESLDQYMVTW
TVKYYELEEKIISLIKVVIDVLMDFHTKYSDSASGLTSHLLSQVEQFVQKDIQEYLGILA
DPDRKRKENTEELSTSAQGIITNWTVVKKKILSVSPQQVRYKKAFLIKI-----------
---------ALREMILAF------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------

-----------------------------------------------MGPPRPALP----
------LLLLL--LAAAFARA-----XXXXXXXXXXXXXXDATR

PF01347 // ENSGT00590000083139_0_Domain_0 (105, 674)

FKHFRKYVYDYKAESS
SGVPGTADSRSSTKIHCKVELKVPQFCNFILNTSQCTLKEVYGFNPEGKALLKKAKNSEE
FAAAMSRYEL-KLAVPEGKRVVLYPEKDEPKHILNIKRGIISALLLPPETEEAKQVL---
FLDTVYGNCSSDITVKTRKGSVTTEISIERN----LEKCDNFQPIRTGVSPLALIRGMTR
PLSTLIGSSQSC-QYTLDPESKHVSEVICKEQHLFLPFSYKNKYGMMTQVSQTLKLEDTP
--RINSRFFDEG-PEAVGLAFESTKSTSPPKQ-AEAILQTLQELQKLHDSEQNAQRANLF
YKLVTELRGLSSEAVASLLPKLIEVSS--PITLQALIQCGQPQCYTRILQWLKTEKANPL
LIDVVTYLVALIPQPSAERLREIFNTAKEQHSRATFYALSHVINNYRK-TDPAGTQDL-L
DIADYLLEQIRDDCTGNEDHTYLILRVIGNIGRTMEKLTPKLTSSILKCIESRQPSLLIQ
KAAIQALRKMELRDEVREVLLQTFLSNTSPGDKRLAAYLMLMRGPSLSDVSKITELLPWE
QNEQVKNFVASHI

ENSGT00590000083139_0_Linker_0_3 (674, 709)

ANILTSDELSIQDLKKLVEEALKKSQ-LPTVMDFR

PF09172 // ENSGT00590000083139_0_Domain_3 (709, 1025)

KFSRNYHQIPPL
GA-------SXXXXXXXXXXPNDYLPKESMLKATLTVFGFAPADLFEIGLEGKGFEPTLE
ALFGKQGFFPDSVSKALYWVDGQVPDRVSKVLVDHFGYSKDDRREQDMVNGIMLNVDKLI
KDLKSKELPEARAYLHILGEELGFVKLHDLQLLGRLLLNGVHTLQGIPQLIR-ETIRKGS
KNDLFLHYIFMDNAFELPTGLGLQLQVSSSGVITPGMKAGVKLEVA-NMQAELVTKPSVS
VEFVTNMGVIIPDFARSGVQMNTNFFHETGLEARLAMKARQLRFIIPSPKRPVKLFSGXX
XXXXXXXX----XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMKQTEATLMFRYNR
QSKTLSSEIQIPDFDVDLGTVLRVSDDSAKEKQSYRLTLDFQNKKITEVTLTGHISYDRK
EEGKIKGVISIPRWQAEARSEVLTQWSPSKLLLQMDSS--ATAYGSTISKKLAWRYDEEK
IEFEWNTGSNVDTKKAASSFPM----DLSDFSKSLHMYASRLLNHRVPPTDMTFQDMSSK
LIDATNIWLLEASRNLPYGQKLRDHFSGLQEXXXXXXXXXXXXXXXXXXXXXDGRIRYTL
NKHSMKIEIPLPFGGKSSKDLKMFKTVWTPALNFKSVGFYLPPREFQVPTFTIPRLYPLQ
VPLLGVLDLSANIYSNLYNWSASYTGGNS-T-D--HLSLQAQYHMKADSLXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXX---XXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXFA
TSNKVDLTFSKQSALLRSEYHADYKSLRFFTLLSGSLNSHGLELNADILSTDKINSGAHK
ATLRISQDGVSTSATTNLKYSPLVLENELNAALSLSGASMKLTTNGRFREHNAKFSLDGK
AALTEVSLGSAYQAMILGVDSKNIFNFRINQEGLKLSNDMMGSYAEMKLDYTNNLNIAGL
SLDFSSKLDNIYSSDKYYKQNVNLKLQPYSLVTTLNSDLKFSALDVTNTGKLRLEPLKLN
VGGTIKGTYQNNEIKHIYTISYADLS-ASYKAXX---XXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXYIKDNYDLHDFKEAIAKIIDQIIEKLKILDEHYHIRVNLVKKIHDLYLFIEKINF
NKIGTSTASWVQNMDTEYQIRIQIQEKLQRFKTQIQNIDIQHLAERLKQLVEAIDVRVLL
DQLRT-IPFRRIKEIIEYIKYCVVSLFEDFEVTEEINAFRGIVHELIKMHEIDQHIQILM
NKSVQLVRQYKLQETVQKLSSVLQQVKIEDHVEKLTGFIDAALKQLEALSFKQFVEEVNK
FLDMLVKTLRSFDYHQFVDKTNHQICEVTQRINGEIQALELPQKAEAL-KLFAEDVKSVV
SAYMENLGATKITVFFDWLQGTLNSTSVVHMKAKFQEILEDIRDRMYQMDLQREAQRYLF
LVGQVYNTLVTYISDWWSLAAKNLTDFAEQYSIQDWAENLKALVEQGFTVPEIQTTFGTI
PAFEVSLHALQ-ATYQTPDFTVPLTDL-IPSVQINFKS-KIIKIPSXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXTIDQMLNSELQWPVPEVYLRDLNGVDTILARITLPDFHLPEIT
VPEFVIPNLNLTDFQVSDLRIPEFQLPHISHTIEVPTFGKLYGLLKIQSPLFVLDANANI
QNATA-SASKAEIEAAFTAEGKSKLEVLNFDFQANAQLSDPT--TKPLVLKETVRFSSKY
LKTEHESEVLFSGKVIEGKSNTVAGLHTEKNTVELSNGVLIKITDQLTLDSDTKYFHKLN
IPKLDFSSQADLRNEIKTLLEARHIAWTSSGTGSWKLARHKFSDEGTHEAQIRFTVEGPI
TSFGLSNKIYSKYLRVNQSMVYESGFLNFSKFEVQSQAECQYVGRSVLTAKGMVLLGEGK
AEITGNHDAHLNGKVIGTLKNSLFFSSQPYEITASTNNEGNLRVSFPLKLTGKIDFLNNY
ALFLSPGAQQASWQASARFNHYKYNQNFSAVNNEKITEAYVGINGEANLDFLNIPLTIPE
VT--LPYIRLTTPQ-VKDISLWEKTGLKGFLKTTKQSFDLSVKAQYKKNKDMHSISVPLD
AFYALINHNIHSFNRHFEKVRNKALYFFNKSYNEAKTTFDKYKVEKSLNEQPKTFQIPGY
TIPV---INIEVSPFTMEMLPYSYVIPKEISTPSITIPGSGIYVPSYTLVLP-FLELPAL
HVPRNLLEFSLPELKGLSTPNKILIPAMGNITYDFSFKSSVITLNTNVGLYNQSDIVAHF
LTSSSSVINALQYKLEGTSSVTRKRGLKLATALSLSNNRFVAGSHDSTISFTKKNVDASV
TTTARVHIPILRMNFKQELNGNTKSKPTVSSSIELKYNFNSPKLYSTAMGAVDHKLSLES
L-----TSYFSIESSTKGDVKGSVLS-REYSGIIASEASTYLNSKGTRSSVKLQGASKVD
GIWSIEVKESYAGEATFQRIYAILGNNMKNHLQLKGXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXNTAGFKQLTVSMPEQTIEVPSIKFSVPAGISIPSFGTLTARFRVASPLYNAS
WSAGLKNKEDHVETFLDSTCSSTIQFLEYDLNVVGTHKIEDGMLVSNTTGTFAHRDISAE
YQEDGQYQELGYWDAKVLLNISSPTLTDVHLRYEDGEN-HLSSSVASPAIGTVGIDLEDN
D-TLWKLNL---YYQ-PQSSPDKRFNIFKIEMR--DEESDEEFQIKVNWEEAAVS-ELLS
SLKDSVPKATGAFYDYVNKYHREYTGLDLKDASLKLRRSLQSSADQAYQEAVRQTDEVD-
-MRLQRLARGTTKTYQQWKDKAQSLYQELL-AQEDQGDFQRLQNRVFDSLIGVAQESNVT
VKRVTDSFIDFLKFIRFQLPGRAEDYTGDELCSMVIMEVGKVLSQVHSKIQSGLEILFSY
FQD----------LMITFPFGSMIYQ---------LIDLISEYGKLLK----LLSEEVQK
AFSDLQSVKI-TELLSDLQRFL-QSIFQEIEEELQHLKEKFPYLINDTQDK-TNTTFNIH
IPFAFRLLKEYPDLNFGDFN----ELVQNTLQEAFQELQQLHQYIKDLRKEYFDPSMVGW
TVKYYELEEKIISLIKYLVGVLKDLHSICTVGAA----QLSRQVERFVQEDIQEHLSILA
DADGKGKEKIAELSTSAQEIIKSWAVAMKEIISDYHQQFTYKLQNFSDYLSDYYEKFIAE
SKRLIDLSIQKYHVFLRCIMDLLKKLQS-ATEDNISPYIKVAPGGFTITF----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------

------------------------------------------------------------
----------------------------------------DATR

PF01347 // ENSGT00590000083139_0_Domain_0 (105, 616)

FKHLRKYVYNYEAESS
SGIPGTADSRSATKIHCQVELEVPQLCSFILRTSQCTLKEVYGFNPEGKALLKKTKNSDE
FAAAMSXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXSALLVPPETEEAKPLL---
FLDTVYGNCSSDVTVKTRTGNVATEISIERN----LQKCDRFKPISTDVSPLAFIKGMIH
PLSTLISSSQSC-QYTLDSKRKHVSEAICKEQHLFLPFSYKNKYGMMAHVTQSLKLEDTP
--KINSRFFGEG-AEEVGLAFETTKSTSPPKQ-TEAILKTLQDLQKLSVSEQNAQRANLF
NKFVIGLRGLNNEAVTSLLPRLMEVSS--PITLQALVQCGQPQCYTYILQWLKSQKAHPL
LIDVATYLMALIPEPSRERVQEIFNTAKEQQSRATLYALSRVVNNYHS-ITPQTTQIL-L
DIEEYLLAQIANDCTGDKDHTYLILRVIGNMGKAMEQVSPKLKSSVLKCIRSKQPSPLIQ
KTAIQALRKMQSSEE

ENSGT00590000083139_0_Linker_0_3 (616, 709)

XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXLKTLLEEALKESQ-LPTIMDFK

PF09172 // ENSGT00590000083139_0_Domain_3 (709, 1025)

KFSRNYQFSKSV
SLPSLD-PVSAKIEGNLIFDPNNYLPRESMLKTTLTVFGFSSIDLFEIGLEGKGFQPTLE
ALFGKQGFFPDSVNKALYWVDGKVPAQVSKVLVDHFGYTKADKHEQDMVNGIMVNVEKLI
KELKSKEVPEATAYLRVLGEEFGFVELNDLRFLGRLLISSVRTLQGIPQMIG-EAIREGS
KSDLFLHYIFMDNALELPTGAGLQLQVSLSGVITPGTTAGIKLEAA-NLQTELVAKPSVS
VEFVTNVGIIIPDFAKSGVQMNTNFFHESGLEARVALKAGELKLIVPSPKRPVKLFSVXX
XXXXXXXX----XXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXX
XXXXX

PF06448 // ENSGT00590000083139_0_Domain_5 (1086, 1157)

FELELQPTGDVERYSASATYELQREGTALVDTLKFVTQAEGLKQTEAIMMFKYNR
QSVTLSSEIQIPDFEVDLGTILRVSDESTEEKKSYKLTKDIQNQKITEVTSRGSVSRDAK
EEGKIKGIISISRWQAEARSEILTQWSQAKLLLQMDSS--ATAYGATISKK-VWSYDEEK
MEFEWNTGTNVNTKKVASSFPV----DLSDVPRSLHEYANSLLDYRVPQTDVTFRHIGSK
LIVTTNAWLQKASGNLPYAQTLQDHLSSLEDMDMQKMGLPDFHIPENLFLKSDGRVKYTL
NNNHVKVEIPLPFGGKSSKDLKIIETVRTPALDLKSVGYYLPSQEVQIPSFTIPKWYLLQ
VPLLGVLDLSTNIYSNLYNWSASYTGGNTTT-D--HFRLKAQYHMKANSVIDLLSYSVQX
XXXXXYDHRHTFTLSCDGSLRHKL-LDSNIKLSHVEKSGNSPASKGS---LTFDATSVWG
PQMSAVVQAHSKKKHHFYVREVKVDGQFRASSFYSKGLLDLSYQRDLNTGQLSGESNMRF
NSSYFQGTNRVTGSYKDGALSLTSASDLQGGLLKNTASLKYENSELVLKSDTNGKYKDFA
TSNKVDVTFSKQNALLRSEYQADYKALRFFTLLSGSLSSHGLELNTELVGTDKINSGAHK
ATLKIDQHGMSTSATTNLRYSPLVLENELNAEIGLSGAAMRSTTSGRFKDHNAKFSLDGK
ATLTEAALGSTYQAMILGVDSKNIFNFKINPEGLKLSNDLMGSYAEMKLDYVNSLTIAGL
SLDFTSKLDNIYSSDKFYKQNFNLQLQPYSLVTTLNNDLKYEPLGLTTSGKLRLEPLKLN
VGGNIKGTYQNSEIKHIYTISYADLS-ASYKADT---VAKGQGVEFNHRLSTYIAGLASA
IDISTNYNSDSLHFSNVFHSVMAPFTVAIDTHTNGNGKLDLWGKHTGQLYSKLLLKAEPL
ALTFSHDYKGSTSHDLMSRRSVDTAVDHKVSALLTPAEQTGTWKLKTQWNKNEYNHDFGA
YNTKDKVGVELSGRALADLTVLDSPLEVPFFLSEPVNVIDALEMRDVADQPQEFTIVASV
KYDKNQDVHIINLPFLKILPEYFERNRIAIITVLESIQKELKRININQFARKYRAALDKF
PQQVNDYLNTFNWEAQVVSAKEKLSVFTKNYKITANDLQTVLDDAKINLSEKLSQLQTYV
IQFDQYIKDNYSPYDIKIAIAKIIDQIIEKLKSLDEYYHIHANLIKTIHDIYLFVEKIDL
NKTGSINAAWIQNVDSKYKIRIQIQEKLQQLRTEIQNIDIQHLAEKLKQQINITDIRVTL
DQLRTTIKVQRIKDFIEHVKYFIVNLIEEFEVAEIINTFRATVLELIKNCKVDQQIQVLI
DKSVELAHQYKLKETLQKLSHALKQVEIKAYFEKLVRYINDNVKKLKALNFENFMGEVNR
FLDMLVKKLRSFDYNQFVDETNNKIREVTQGINGKIRALELPQKAEAL-KLYAEEVKAAI
SVSLENLKDTKITFLLDWLQDAFHSTSLVYVKAKFQETLEDIRDRMYHMDIQQELQQCLS
LISQVYSTLXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXNTVASLQTDKNTLR-RNSVLLKINQTFTLDSNTK-FHKLS
IPKLEFSSQADLHNEMKTLLEAGHVTWTSSGTGSWKWACPKFSDEGTHESQIKFTMGGPV
SSFGLSNKINSKHLRVDQSLVCESGFLNFSKCEIQSQVDSQHVGRSILNAKGTALFKDMK
AEVTGNHDAQLNGKVIGTLKNSLSFSAQPFKITASTNSEGNLKVSFPVRLTGKIDFLNNY
KLLLSPSVQQASWQASARFNQYKYNQNFSVGNNENSMEAHIGMNGEANLDFLNTPLTIPE
MT--LPYTTLTTPQ-VKNFSLWERTGLKDFLKTTKQSFDLSVTSQYKKNKHTHSIPHPLG
VVFEFINQNIKSFKRHFEKGRDNALDPDIKS-----------------------------
--------------------------------------------------------HNVL
HVPTSIHKLFLPDFELPRT-SNILIPAMGNITYDFSFKSSFITLSTNAGLYNQSDTVAHF
LSSSSSFIDALQYKLEGSSSLTRKRGLKLATALSLN-NKFVEGSHDSTISLTKKNMETSV
TTAAKVQIPILRMNFKQELHGNTKSKPTVSSAIELKYDFNCPKLYSTAKGAVVHKLSLEG
L-----TSYFSLESSTKGDVKGSVLS-QEYSGNVTSEASTYWNSKGTRSSVALQGVSKVD
GIWNLEVKENFAGEASLQRIYALWDHNTKNVLQIKNIFLTSGEHTSKATLELSPWQMSAL
VQVRAGQPSSFLDIPYFDQEVVLNANTGNQKVSWKSEVRFHSESLQNNVQLSSNQEEARL
DVSGSLEGHLSFLKEIVLPVYDKNLWDLLKLDVTTNVGRRQYLRTSAALVYTKNPNGYYF
PIPMQELANEFI--IPGVRVDDPNPVLIIPTFQVPFTNLEVPSYTLNFSEIAISKKLSSL
PFDFNLPTLPKVKFPKVDVLTKYYEPEDSSVPFFEVTVPESQLTVSPFSLPKSISVGGVV
LDLNKVANKIADFDLPTITVPEQTIEIPSMKLTVPAGIFIPSFGSLTAHFGVASPLYNTT
WSAGLKNKGDHLETFLDATCSSTLQILEYDLNIVGTHKYEDGTLVCKTQGTVSHRDFSAE
YKEDGKYQGLMTWEGDISLNITSPRFTDVRLHYQAVKQ-NLSSLVASPAVGTVVMDWGEN
N-DDFKWDF---YYY-PKSSPDKMLNIFRTEWR--YQESNDEIRIKVNWEEEAAS-QLLS
ILKDNVPKATGALYDYVNKYHQEHTGLDLKDASSRLKASLQNSAEQAYQGAMRWVHEVE-
-LGLQTVASSTTRTYQQWKDEGQNLYQELL-DQKNQTSFHKF-DTVYKSSLRVIQEYYRT
VKHLIDSLIEFLKVTRFQCR-KAGLYTGDEXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXX------XXXXXXXXXXX---------XXXXXXXXXXXX---------XXXX
XXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXLEEKEFTDLINDIQHVVSVIVDTY
FSNIFKFLKESLYLELVKFN----ELIQNKYQEASQELQMLHQYIKALREEYFDPSVVGW
TVKYYELEEKTVDLIKNLLAVIKDLYLRYAESAVDFA---------------CEYLNILT
DADGKGKEKIAELSTTAQDIIKSWAAAMKEIISDYHQQFRYKLQAFSDQCCDYYEKFITE
SKRLIDLSMQNYHMLLRYITKFLKNLQS-AVADDMTSYIKVAPGELIITL----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----MSRY

PF01347 // ENSGT00590000083139_0_Domain_0 (189, 673)

EL-RLAIPEGKQAVLYPEENEPAHILNIKRGIISALLVPPETEEAQQEL---
FLDTVYGNCSTHTAVKTRKGSVATEMSTERN----LQQCSGFQPASTGASPLALIKGLAR
PLSTLISSSQSC-QYTLDPKRKHVSEATCKEQHLFLPFSYKNKYGMMTQVTQTLKLEDTP
--KINSRFFGGG-TQKVGLAFESTKSPSLPKQ-AEAVLKTLQELKKLSTSEQNAQRANLF
NKLVTNMRGLSSEAITSLLPQLIEVSS--PITLQALVQCGQPQCYTHVLQWLKSEKAHPL
LIDAVTYLVALIPDPSVQRLREIFSIAKEQQSRATLYALSHVANNYFE-ATRTVDPDL-Q
DIINYLQEQIQDQCAGDEDHAYLILRVIGNMGRTLESIAPMIKSSVLSCIRSPKGSVLIQ
KAAIQALRKMELGYEDRELLLQTFADSTSPVEKRLAAYLMLMKQPSQSDISSVIQLLPQE
ESEQVKNFVASH

ENSGT00590000083139_0_Linker_0_3 (673, 709)

VANILNSEELYVGDLKTLVKEALKDSQ-LPTVMDFR

PF09172 // ENSGT00590000083139_0_Domain_3 (709, 1017)

KYSRNYHVSKSV
SLPSLD-PVLAKIEGNLIFDPNNYLPKESMLKTTLTIFGFASADLFEIGLEGKGFEPTLE
ALFGKQGFFPDSVSKALYWVNGQVPDRVSQVLVDHFGYTKDDKHEQDMVSGIMPIVDKLI
RDLQSRDMPEARAYLRILGRELGFFKLQDLQLLGKLLLSGARTLQGIPQMIS-EAIREGS
EHDLFLHYIFMDNTFELPTGVGLQLQVSSSGIISPGSKAGLKLQVA-NMQADLLMKPAVS
VEFVTNMGVIVPDFARSGVQMNTNFFHESGLEARVALKAGQLKVIIPSPKRPVKLF

ENSGT00590000083139_0_Linker_3_5 (1017, 1044)

SGSN
TLHLISTT----KTEVIPPLMEN

PF06448 // ENSGT00590000083139_0_Domain_5 (1044, 1156)

RQSWSACRPFLTGLHYCTAG-AYSNASSTESASYYPL
TGDTRYELELKPTGEVEQYSASATYELQREDKALVDRLKFVIQAEGVKQAEATLMFKYNR
RSRTLSTEMQIPDLD

ENSGT00590000083139_0_Linker_5_6 (1156, 4658)

VNLGTILRVSDESSKDKRSYKLNLDIQNKKITEVALSGHISHDTK
GEGKIKGVISIPRLQAEARSEILSHWSPTKLLLQMDSS--ATAYGSTVSKRVAWRYDDEK
VEFEWNTGTNVDTKKVASNFPV----DLSDYLRSLYMHANGLLHHRIPQTDMSFWDMGSK
VIVTTNTWLQEASSSLPYAQILQDHLSSLTELDLQKMSLPYFHIPDNLFLKSDGRVKYTL
NKNSIEVDIPLPFGGKSSKDLKMFDTIRTPALNFKSVGFYLPSREFHIPTFTIPELYQLR
VPLLGVLDLSTNVYSNLYNWSASYTGGNTSR-D--HFTLQARYHIKADSAVNLLSYSLQG
SGETTYDHRNTFTLSCDGSLRHKF-LDSNVKFSHVEKLGNNPASKGV---LTFDASTTWG
PQVSASVHLDSKKKQHLYVRDVKIDGQFGASSFYAKGTYSLTCQGDPATGQLSGESDLSF
NSSYLQGTNQITGRYEDGALSLTSTSDLQGGTLKNTASLKYENYELTLKSDTNGKSENFA
IRNRVDLTFSKQNALLHSEYEADYKSLKFFSLLSGSLNSHGVELNADILGTDKVNTAAHK
ATLSIGRSGISTSATTNLKYSPLFLENELNAELGLSGASMKFTANGRFREHSTKFTLDGK
AALTEVSLGSVCQAMVLGVDSKNIFNFRISGEGLKLSNDLKGSYGEITLDHANSLNTAGL
SLEFSSKLDNIYSSDKFYKQHFNFQLQPFSLVTTLNNDLKYSALGLTSSGKLRLEPLKLN
VDGNLKGAYQNNEIKHIFTISYVDIS-ASYKAST---IARIQGMQFSHQLNTGIAGLVAS
LDTSTNYHSDSLRFSSALHSAVAPFALAINAHTNGNGKLALWGEHTGQLYSKFLLKAEPL
ALTFSHDYKGSTSHSLLSRESIGMALDHKLSALLTPSEQTGTWKLKTQLNSNEYSQDFDA
YNTKDKIGVELSGRGLADLTVLDSPIKVPFFLSEPINIIDTFRMKDTVQQPQEFTIAAAI
KYDKNQDVHTISLPFFKSLPEYLEKNRLMIITALEAMQKELKSLNIDQFVGRYRAGLGKL
PQQVNDYLTAFNWESQVASGKEKLTAFAENYRITENDVQTALNNAKISLNENLSQLQTYV
IQFDQYIKDNYDLHDLKIAIVRIIDRIIENLKILDEHYHIRENLVRTIHNAYLFIENIDF
SKMGSSTASWIQNVDTQNQIRIQIQEKLQQARTQIQNIDIQELAAKLKQQVEAIDTRALL
NQVRTTIPFQRIKDIIEHVKYIVISLIEDFEVTEKINAFRAIAHELIKKYEVDQQIQVLL
DKSVQLARQYKLKDTVQKLSNLLQRVDMKDCYKKLLVFIDDIIRQLKAFSFKNFMEEVNQ
FLDALVKKLRSFDYHQFVDETNHKIREVTQIINAELQVLDLPQKAEAL-KLFVEDVRVML
SAFLEKLKDTKITVFVDWLQDALNTAYLVPIKAKFQETLEDIRDRIYQMDIQQELERCLS
LVGQVYSTLVTYVSDWWVLAAKNLTDFAEQYSIQGWAENVKALVEQGFTVPRIQLILGTV
PAFEVSLRALQEASFQTPIFTVPLTDLRIPSVRINFKELKDIKIPPRFSTPEFTVLNTFH
IPSFTVDFLEIKLKIIRTIDQMLSSEFQWPVPEVYVGDLKVEDILPARLFLPNFHLPEIT
IPEFLIPNLNLTEFQVPDLHIPEFQLPPISHSAEIPALGKLNSILKIQSPLFTLDAKADI
HNITT-SEHQTGTEVSIAAKGESKFEVFNFDFQANAQLLDPKT--NPLLLKESMNFSSKH
LRMEHKSEILFSINAIEGKSDTVASFSTEKNTLELNNGVVVKMKGQLTLDNHMKYFHKLS
IPKLDFSSKADLRNDLKTLLKVGHITLTSSGAGSWKWACPSFSDEGTHESQINFTVEGPL
ASLGLANKINSKHLRVTQNLAYESHFLNFSKFEIRSDVESQHVGHSILTAKGTALLGKGK
AEITGDHSAHLSGKVIGTLKNSLFISAQPLEITASTNNEGNLKVSFPLRLTGKIDFLNNY
ALLLSPSAHQTSWQASAGFNQYKYNHNFSASNNENSIDAHVSINGDANLDFLNIPLTIPE
MN--LPYTTFKTPS-LKDFSIWEETGLKEFLKTTKQSFDLNVKIQYKKNKDKHTIAVPLG
VFYKFISQNVNSLDSYFENVRDNALDFLTTSYNELKIKLDEYKAERSLNKLPRTFPRPGY
TIPI---VNVEVTPFSVEMLPSGHMIPKAVHTPSFTIPGFDFYVPSYMLSPP-SIELPDL
HIPRNLLKLSLPDFKGLSTVNNIFIPAMGNITYDFSFKSSVITLNTNAGLYNQSDIVAHF
LSSSSFVIDALQYKLEGTSRLTRKRGLKLATALSLS-NKFVEGSHDSTISITKKIMEASA
TTTAKVHIPVLRMNFKQELNGNTKSKPTVSSSIELTYDFNSPKLFSSAKGAIDHKLSLES
L-----TSYFSIESSTKGDIEGLVLS-REYSGAIASEASTYLSSKATRSSVKLQGSSKVD
GIWNVEVKENFAGEATLRRMYAMWEHSMKNHLQPYSGFSTHGEHTSKATLELSPGSVSAL
IQVRAREINSVLDIPHLGQEVALNANTKNQKFSWKSEVQGQLGTLQNHVQLSNDQKEARF
DIAGSLEGRLHFLKFITLPVYDKSLWDLLKLDVTTSSQKRQYLHASTALVYTKNPKGYPF
SVPVQELTDEFI--VPGLKLSDLSSDFATPTFRVPFTDLQIPSYKLDFNEIRIYKKLSTS
PFALNLPTLPKVKFPQVDVLTKYSEPEDSSVPFFEITIPDVQLTVSQFTLPKSLSVGSAV
LDLSEVANMIGDFELPTITVPEQTIEIPSMKFSVPAGVFIPFFGALTARFGVASPLYNAT
WNVGLKNKADHVETFLDSTCSSTLQFLEYDLNVVGTHSLEDGMLICKIKGTLAHRDFSAE
YKEVDKYKGLKAWEEDVNLDILSPAFTELHLRYREDEN-SMSFSAASPAVGTVGLDLETE
GDRSFKGNL---YFQ-PQSSPGRKLNIFKTEWR--YQESDDKIQMKFNWEEEAAS-RFLG
SLKDNVPKATGAFYDYVDKYHQEYTGLSLKDASSKLRRSLRESAEGAYQRARRQINKMD-
-VGLQRAASSTIGTYQEWKEKAQDLYQELL-AEEGQASSQRLKDKVFDSLFQATQEARMA
AKCMMDSSIGFLQLTRIQLPGIAGTYTGEELCTMVIKEIGKVLSWAYSNIHSELEKLLSY
AQDLVEKSELIKDLQITFPFYSESYK---------LTEVILKSRKLLE----FLSKNVQD
VFIDLQSIKL-SETLGDLQSSL-QIIFERIEEEIKYLKETRFIHPINA----IDTIFNTY
IPFAFRVLKESLYLNLTKFN----EAVQNNLQVASQGLQQTHQYLKALREEYFDPSIVGW
TVKYYALEEKMVDLVMDLVIALKNLHSTYTAYAASSASQLSALVEQFVHKDVQEYLSILA
DADRRGKEKIAELSNSAQQVIKTLTTAMKEIVSDYLE

PF12491 // ENSGT00590000083139_0_Domain_6 (4658, 4713)

QFISKLQEFLDQFPDYYEKFIAE
SQRLIDLAIQSYHVILSYITELLKKLQA-ATASGGNPYVKLAPGELTITY----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----MSKY

PF01347 // ENSGT00590000083139_0_Domain_0 (189, 674)

EL-RLAIPEGKQVLLYPEKEEPKHILNIKRGIISALLVPPETEEDEQVL---
FLDTVYGNCSSDLTVKTKKANVATGISIERN----LEKCDRFKPISTGVSPLALIKGMIG
PLSTLISSNQSC-QYTLDPKKKHVSEAICKEQHVFLPFSYKNKYGMMAQVTQTLKLEETP
--KINSRFFDEG-TEEVGLAFEITKSTSPPKQ-AEAIVKTLQELQTLHVSDQNAQRANLF
NKLVTELRGLNNEAITSLLPKLIQVSS--PVTLQALIQCGQPQCYTHILQWLRSEKANPL
LTDVVTYLVALMPEPSAERLQEIFSTAKEQQSRTTLYALGHVVNNYHE-TNPVVTQAL-L
DIADYLLEQIRDDCTGNEDHTYLILRVIGNTGRTMETVSPRLTSSILKCIQSSEPSLLIQ
KAAIQALRKMELKDEVREVLLQVFLSDASPGDKRLAAYLMLMRSPSQSDINQIVQFLPRE
QNEQVKNFVASHI

ENSGT00590000083139_0_Linker_0_3 (674, 709)

TNILNSEELYIKDLKSLVEDALKGSQ-LPTIMDFT

PF09172 // ENSGT00590000083139_0_Domain_3 (709, 1017)

KFSRNYHLSKSV
SLPSLD-PVSAKIEGNLIFDPNNYLPKESMLKTTLTVFGFAPADLFEIGLEGKGFEPTLE
ALFGKQGFFPDSVNKALYWVDGQVPDHVSKVLVDHFGYTKDDKREQDMVNGIMLNIEKLI
KDLKSREFPEARAYLRVLGEELGFVRLHDLQLLGKLLLNGVRTLQGIPQMVG-EAIKKGL
RSDLFLHYIFMDNAFELPTGLGLQLQISSSGVITPGIRGGMKLEVA-NMQAELMAKPSVS
VEFVTNMGIIIPDFSRTGIQMNTNFFHETGLGVQVAMKAGQLKFTVPSPTRPIRLF

ENSGT00590000083139_0_Linker_3_5 (1017, 1044)

SGSN
TLHLVSTT----KTQEVPPLTEN

PF06448 // ENSGT00590000083139_0_Domain_5 (1044, 1156)

RQSWSTCKPLFTGLDYCTSG-SYSNASCPEATSYCLL
PGGTRFALELKPTGEVEQYSASATYELQREGGILVDTLKFVTQTEGVKQSEATMMFKYNR
QSMTLSSEIQIPDFD

ENSGT00590000083139_0_Linker_5_6 (1156, 4658)

VDLGTVLRVRDESAMEKKSYKLTLDIQNKKITEVTLTGHISYDRN
EEGKIKGVISIPRLQAEARSEILTQWSPTKLFFQMDSS--ATAYGSTISKKLAWRYDEEK
IEFEWNTGTNVDTKKAASNFPL----DLSDYPKSLHMYANSLLDHRVPQTDMTFRHMGSK
LIVATNTWLQKASGSLPYAQNLQDHLSGLKELYLQKMGLPNFHIPENLFLKSDGRVKYTL
NKNSVKIEIPLPFGGKSSKDLKMLEAIRTPAINFKSVEFYLPSQEFQVPTFTIPKSYQLR
VPLLGVLDLSTSIYSNLYNWSASYTGGNTST-N--HLRLQTQYYMKADSVVDLLSYSVQG
SGETTYDHKNTFTLSYDGSLHHKF-LDSKMVFSHTEKIRNNPVSKSL---LTFYASSAWG
PQMSASVHVDSKRKHHLYVKEVKIDGQLRVSSFHAKGTYDLSYQKDSTTGQLSGESNLRF
NSSYLQGTNQITGRYEDGIVSLTSTSNLQGGIIKNTASLKYENYELTMKSDTDGKYEDFA
TSNKIDLTFSEQNALLRSEYQADYKSLRFFTLLSGTLNSHGLELNADILGTDKSNSGVHK
ATLRITRDGMSTSATSNLRYSPLVLENELNAALGPSGASVRLTTNGRFREHNAKFSLDGK
AALTEVSLGSVYQAMILGLDSKNIFNFKISQEGLKLSNDMMGSYAEMKLEHTNNLNIAGL
SLDFSSKLDHIYSSDKFYKQNFNLQLQPYSLVTTLNNDLKFSALDLTNSGKLRLEPLKLN
VGGNIKGVYQNNEIKHIYTLSYADLS-ASYKTDT---VAKVQGTEFSHRLNTNIAGLASS
IDISTNYNSDSLHFSNVFHSAMAPFTMTIDAHTNGNGKLSFWGEHTGQLYSKFLLKAEPL
ALTVSHDYKGSTNHHLPLKSSISASLDHKVSALLTPAEQTATWKLKTQLNKNEYSQDFDA
YNTKDKVGVELRGQALADFNMLDFSIQVPFFLSEPTNIIDALGMRDAIDQPQEFTVVAFV
KYDKNQDVHTINLPFFKILPEYFEKKRMVIIMALETIQRELKVINIDQFMTKYREALDKL
PQQVNDYLNAFNWESQVVSAKEKLSAFTKHYRMTENDLQIALNNTKINLNEKLSQLQTYV
IQFDQYIKDNYDLHDFKTAIAEIIDQIIEKLKTLDEHYHIHENLVKTIHDVYLFIEKIDF
NRIGSSPASWIQNADTRYQIRIQMQEKLQQLKTQIQNVDMRHLAEQLKQQVEAMDVRVLL
HNLRTTIPFQRVKEIIEHIKYYVIHLMEDFVVVDKINAFGAKVHKLIKIYKIDQHIQVLM
DTSVQLAHKYQLKETVEKLSNVLQQVNIKDHFEKLVRLIDDAIKQLKALSFKKIIEEVNR
FLDMLIKKLRSFDYHQFVDETNNKIREVTQRINGEIQALALSEKAIAL-TLFVEDIKAMV
SVHLENTKDIQITLFFDWLQEALSAVFLTSMKAKFQETLEDIRDRVYQMDIQQEVQRYLS
LVGQVYSTLVTYISDWWSLAAKNLTDFAEQYSLQNWAGNLKALVERGFTIPEIQTIFGTI
PAFEVSLRALQEATYQTPDIIVPLTDLKIPSVQINFKSLKDIKIPSRFTTPEFTVLNTFH
VPSFTIDLVEIKVKIIRTIDQMLSSELQWPVPEIYLRDLKGLDTILAGITVPDFYFPEIA
IPEFIIPNLDLKNYQIPDLHIPEFQLPHLSHTVEVPSFGKLHGILKIQSPLFILDANANI
QNATT-SGNKAEIAASITAKGESKLEVLNFDFQANGQLSDSNI--NPLVMKQSMRFSSKY
IKTEHESEVLFFGNAVEGKSNTVAGLHTEKNMLEFSNGVFVRINNQLTLDSNTKYFHKLN
IPKLDFSSQAELRNEIKTLLEAGHVAWTSSGIGSWKWAHQTFSDEGAHESQVSFTVEGPI
TSFGLSNKISSKHLRLSQNLVYESGFLDFSKFEIQSQVESQYVGRSVLAAKGTALLGERK
AEITGNHDAHLNGKVIGTLKNSLFFTAQPFEITASTNNEGNLKVSFPLKLIGKVDFLNNY
ALFLSPSAQQASWQASARFNQYKYHQNFSAGNNENSIEAHVGINGEANLDFLNIPLTIPE
MT--LPYTGLTTPQ-VKDFSLWEKTGLKEFLKTTKQSFDLSVKAQYKKNKDKHSIPIPF-
------------------------------------------------------------
------------------------------------------------------------
---------YVKDFQAVSTPNNILIPAMGNITYDFSFKSSVITLNANAGLYNQSDIVAHF
VTSSSSVTDTLEYKLEGTSSLTRKRGLKLATALSLS-NKFMEGNHDSTISLTKKSMEASV
TTSAKVQIPILKMNFKQELNGNTKSKPTISSSIELTYDFNSPKLYSTATGAVDHKLILES
L-----TSYFSVESSTKGDIKGSVLS-REYSGTIASEASTYLNSKSTRSLVKLQGASKVD
GIWNLEVKENFAGEATIRRIYAIWEHNTKNHLQLEGFFLTSGEHTSKATLELSPWKMSAL
VQVRASQPNSLLDISYFGQDVSLNANSEHQKVSWKSEVQVHSGFFQNNVHLSNDQEEARL
DIASTLKVSLWFLKDIALPVYDKSLWDLLKLDVTTSIDRKQYLHASTSLVYTKNPNGYHF
SVPVQELADKFI--VPRLKLNGLSSGLVIPAFQVPFTDLQVPSYTFDFSEIKIYKKLSSL
PFALSIPTLPKVKFPKVDVLTKYSEPEDASVPFFEITIPASQLTVSQFTLPKSISVGSAV
EYLNEVASKIADFELPAITMPEQTIEIPSIKFSVPAGIFIPSFGALTAHFGVASPLYNAT
WSTGLKNKVEYVETFLNSTCSSTIQFLEYDLNVVGTHKIEDGVLFYRTKGTFAHHDISAE
YKEDNKYRGLWDWKEDIRLDITSPTFTDVHLHYQLNKN-SLSSSVSSPAIGTVALDLEGN
N-NTLKWNL---YYR-PQSSLDKKLNIFKTEWR--YQESDDKSQIKVSWEEEAVS-ELLS
SLKDNVPKATGVLYDYANKYHQEYTGLNLRDASLKLRRSLQNSAEWAYESTMRQTDEVD-
-MGLQRVARATTRTYQQWKDKAQDLYHELL-AQEGQADFQGLQNKVFDRLMGVTQEYKDK
VSHQVASLIDFLQFTRFQLPGKAGTYSRDELFTMVMREVGQVLSQVYSKIHSGLEILFSY
FQDLMEKSELIKDVEIKFPFNSESYK---------LRDVVLEFGNLLK----SLSQNIQD
ALNNLQSIKT-TEMLSHLQRYL-ERAFQEIEEEIQRLKGKKFTYLINDIQHVINRIFKKY
IPTAFTFL----KINFDKFN----ELVQNQLQEASQQLQQLHQLIKDLHKEYVDPTVVSW
TSRYYELEEKIISLIKNLVDVLMDFHSKYTISTAGLISQLSNQVEQFVQKDIQEYLSILT
DADGKGKEKIAELSTSAQEIIKSQATAMKEIISDYHQ

PF12491 // ENSGT00590000083139_0_Domain_6 (4658, 4715)

QFRYKLQDFSDQLSDYYEKFITE
SKRLIDLSTQTYHMFLRYITELLKELQS-ATVNNMIPSIKVSPGEFTITF----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------

-----------------------------------------------MGPLRL-------
----------LLLLLLLLIASGPSSQEEGSEAPG-ASCPKDATR

PF01347 // ENSGT00590000083139_0_Domain_0 (105, 673)

FKHLRKYVYNYEAEST
SGVTGTADSRSATKINCKVELEVPQLCSFVLKTSQCTLREVYGFNTEGKAMLKKTKNSEE
FTAAMSKYEL-KLSIPGGKQVSLYPDRDEPTHILNIKRGIVSALLLPQETEEDQQQL---
SMDTVYGNCSSQITVKARKGSTATEMTIERN----LKQCDHFSPISGDMSPLALIRGSNN
PLSTLIKSSQSC-QYTVDNRRKHVSEVVCTEKHLFLPFSHKNQYGMMTQVRQTLKLEDTP
--KINNRVFDEASLPKKRLAFEKTENTPPK-Q-GEDVLKTLKDLQKLSATEQSNQRANLF
GKLVTGLRGLNEEEMLSLLPKLIEVSS--PITLQALMQCGQPQCYSQVLEWLKVEKVNPL
VLDAITYIVGLLPEPSSQRVRDIFKTAKDQQSRATFYALSHVVISFYD-SNKEVTQDL-K
DIAEYLMAQIGNECSGNEELTFLTLKVTGNMGKVMDLANPKMKSSILKCITNPTSS-SVQ
KAAIQALRKMELTDEVRGVLLQVFQDNSSPVDKRLAAYLILMRDPSQSDIHKVAKTLLKD
NSQQVKSFVASH

ENSGT00590000083139_0_Linker_0_3 (673, 709)

LANILESDEAFVQGLKGKVEEALKGSQ-VPTAMDFR

PF09172 // ENSGT00590000083139_0_Domain_3 (709, 1025)

KFSRNYQISKTV
SVPDLD-PISAKVEANLIFDPNHYLPKEAILKTTLKLFDH-TEDVFEIGLEGKGFEPTLE
ALFGNKGFFPDSATQALYWVDGKVPNQVSRALEDHFGYSKDGKREQDMMKGIMANIEKLI
KEVQSKEAPEASAYLRILGEELGYLKLSDLKLLGHLLFKSANTMQTIPQMIA-EALSKGT
QSDLFVHYIFMDNNFDLPTGAGLPLQVAFSGIVAPGARAGMKIQAA-NMQAELIAKPAVS
VEFVTHIGVVIPDFARSGVQMNSNLYHESGLEARVTLKAGQLKFIIPSPTGPVKLFSASN
TLHL

ENSGT00590000083139_0_Linker_3_5 (1025, 1042)

VSTT----KTDVIPPFI

PF06448 // ENSGT00590000083139_0_Domain_5 (1042, 1156)

ENRQSQSTCKHFFTGLNYCTTV-VYSNASSTDAAPYYPL
TGDTRFEFELQPTGEVQEYSASVKYESQKEGKDLVDSLKFGVQAEGAKLTEAAVILRYNR
GKRSLTGDLQIPEFGVDFGANLRVKDDSAQDKKAYTLILDINNNKIPEITITGQMRFDGN
EEGMIGGIISIPRLQAEARTETLFQRSLKKLVLQTDSS--ATAYGMTLSKKIGFHYDDEK
VEFEWNTGSNTNTKKVAAIFPV----D---ISKSLHQYANDLLDHKVADPDMTFRHIVSN
SVEATSTWLQSAAKNVPYAQTLQKKLRNLQELSMEKMGLPDFQVPENLFLKSDGRIKYSW
NENKFEIAIPVPFGGKSSQDMKVPQSVRMPELKLESVGIHLPSQEFTIPPFAVPKFYQLQ
VPLLGVLELSTNVYSNLYNWSASYTGGNTSQD---NFSLQSRYHVKADSIVDLLSYNVQG
SGETTYDYKNTFTVALDGSLHHKF-LDSRLKFNHRETLGNHPVSKAS---LTFDSSSSLG
TQVSVSANFDSKRKQHLSIKDAKIDGQLTISSFVAKGAYSLSYNRDVNTQHINGESNLRF
SSPYLKGSNQITGRYADGALSISSASDIQSGTLKNTASLNYENSQLTLKSDTSGKFQDFA
ATNKIDVSLSRQNAQLRSETQTDYKNLRFYALFSSSLNSQGLELNADLLGTDQTNRGAHK
ATLRISQDGLSTSATSNLRLSALFLENEVNAGLGTSGALVKVTSNGRFREHNAKFTLDGR
VALTEIALGSLYQATIFGADSKNVFDFRINREGLKFSNGIMGAYKEIKLENNNNLNLAGL
TLDFTSKLENTISSDKSYKHNFNFQLQPFSLLATLTNDFQFGTLAATNNGKLRLEPLKLN
LAGNVKGSYKSDEFKHIYALTYADLT-ASYKADT---IASVQGTEFSNRVNLGAAGLSSA
VDISTSYDSKPLHFNNVFRSALSPFTITVDAHTTSNGKLSVLGEHTGQLYSKLLFKGEPL
AFSLSHDFKGSSGHSLESGQKINTGLENKVSALFTPEEQSSIWKLKTQLNQNEFTQDFHA
YNVKDKVGVEFSGRALADLTVLDSPIKVPLLLTEPVNLIDVFALRDTVGQPQEFSLSGSV
KYDKNLHVHVIDLPFLESLPAYFQKIQEAILNALQHIQKYLKSININQYVRKYQAALDKL
PQQVNDYLNQYDLEGKVRSAKEKLIAFTDSYQITTDDLQMTLDNAKINLEKILVQLQSYV
IQFDQYIRNHYDLRSFKTAITDFIDYLVKKWKNLDEHYKIRINTIKAVQEMHSVVENIDI
NKLGSATASWVRDFDGKYQIKAQIQEKLQQLKVQIQNIDLQHHAENLKQQVQALDLKIYL
DRLKVSFPLQRIKAIFEQIKDILINLLEDYEVAEKVSAFRGKIHALVKKFEVDKEIHILM
DKLVHLADQYKLKETLQKLTASLKKIDLRIYFEKLVGFVDDAVKKAKTLHYDQLIEDVNQ
CLDMLIKKVAAFDYNQFVDETNNKILVITQKINDEIKSLELPQKVEAA-KVYIADVNAVI
AHYVEKLKDTKITVIIDWFGDLISSTSLAHLKASIREILEDLRNLIYGIDIPREIQLYLQ
KAGQAYHTVITFISNRWSFVAKEIDKVAEQYDMKNWAENLKVFVERGFTVPEIKTSIITV
PAFEVSLRALQLATFQTPAFRVPLTDLHIPSIQINIKKWKEVKVPSRFTTPEFTVLDTFT
VPSYTIDFKELKLKIVRTIDQLLSSELRWPLPEVYFRDLKMRDFVFSGITLPDFRLPEVK
IPEIVIPKLNLNEFQVPDIQIPTYQLPQVPRAVALPAFGKLSAVFRITSPFFTLNTNAGV
QNTTT-LMNTPEFVASVTVDSKSKSDLLAFTFDASTHLSAPQM--EKLILKQSAKFSQRY
LKTQHESEVVFLGNSIQGTADSLASLHTEKNVLELNNNMFVKLQKQVTFESNTKYTHKLN
IPQADFSSQADLRNEVKALLEAGHVSIVSEGTGSWKWACPHFSDEGTHESLFKFSVDGPI
SLLDLSNQISGKHLKVNQKLTFESGFLSFAKFEVQSEVGSQHLGQSVLTAKGSGLLGEMK
LQLTGHHEANLKGKVDGTLRNSLSFLAQPFEISTATDNEGNVKISFPLKLSGKIDFLNKY
ALVLNSGVQQVSWQAGGRFNQYRYNHNFSAGNNENSIEAQVEMNGDANLDFLSIPLTIPE
QSIPLPFFTIQTPP-VKDFSVWEKTGLKDFLKTTKQSFDLNVKAQYNKNQDWHAIPLPVG
AVYEAIEQNLKSLNKYFEKGRDNALDFLTKSYNEAKIKFDKFKVEPSLNKLPRTFRIPGY
TIPM---VNIEVSPFTAELPAFGYMVPKEISTTGFSIPGIGFSMPSYTLVLP-SLELPVL
HVPNNLRKITLPSFRILSTANYILIPTMGNITYDFSFKSSVITLNTHAGLYNQSDIVAHF
RSSSSSVFEALRYKLDGKTSLTRKRGLKLATALSL-NNKFVEGNHDSTVSLTRRNMEASV
TTVAKVQTPILRMNFRQELNGNTKSKPTVSSLLGLKYDFSYPKLQSSTKGALEHKLTLES
L-----TSYFSVESITKGDTSGSVLS-QKYSGAFTKEANTYLNSKGARSSVKLEGHSKVD
GVWNVEAKENFAGEASIRRLFAIWEHSGKNQLQLQRVFSTKGDQNCRVTLELGLWSVSTL
LQIQASQPSSLLDEASIQQAFLLNANPENQKVVWRGEGHVQTAYVSHEVQLSNGQAEARM
VIAGSVGGHMRFLKDIQVPIYEQSIWDLLKLDVTTSEDQKQYLNVSTGLIYTKSKTGYVF
PLKVNQLADGFT--IPGLKLKGLNSPWTTPAFRVPFTTLEVPSYTLDFSTAKIPKKLSSP
PFDLNLPSLPKVKFPQIDVSIKYTTPDDAQIPFFEIRSPEYHITLSQFTLPKSFTIGTVP
LDLNKVANRIADFDLPTITMPEQKVEIPSVKISIPAGIFIPSFGFLTGDFKVASPLYNIT
WSAGVKNQGDHIESSLDLTCSSTLQFLEYDINVETTYQTEGGTLRGKVTGTLSHRDFSAE
YKEDFTLRGFW-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------

-----------------------------------------------MGPRKPAPR----
------APLLL-LFLLLFLDTSVWAQDEVLENFS-FNCPKDATR

PF01347 // ENSGT00590000083139_0_Domain_0 (105, 673)

FKHLRKYMYNYEAESS
SGVQGTADSRSATKINCKVELEVPQICGFIMRTNQCTLKEVYGFNPEGKALMKKTKNSEE
FATAMSRYEL-KLAIPEGEQIVLYPDKDEPKYILNIKRGIISALLAPPETAEDQQEL---
FLDTVYGNCSTQVIVNSRKGAVPTEMSTERN----LQRCDGFQPISTSVSPLALIKGLVH
PLSTLISSSQSC-QYTLDPKRKHVSEAVCDEQHLFLPFSYKNKYGIMTRVTQKLSLEDTP
--KINTRFFSEG-TNRVGLAFESTKSTSSPKQ-ADAVLKALQEMKKLSISEQNAQRANLF
NRLVTELRGLTGEEITSLLPQLIEVSS--PITLQALVQCGQPQCYTHILQWLKTEKAHPL
LVDIVTYLMALIPNPSTQRLQEIFNTAREQQSRATLYALSHVVNSYFD-VDHSRSPVL-Q
DIAGYLMKQIDNECTGNEDHTFLILRVIGNMGRTMEQVMPALKSSVLNCVRSTKPSLLIQ
KAAIQALRKMELGDEVRTILFDTFVNGAAPVEKRLAAYLLLMKGPSSSDINKIAQLLQWE
QSEQVKNFVASH

ENSGT00590000083139_0_Linker_0_3 (673, 709)

IANILNSEELYVQDLKILIKNALEDSQ-FPTIMDFR

PF09172 // ENSGT00590000083139_0_Domain_3 (709, 1017)

KFSRNYQISKSA
SLPMFD-PVSVKIEGNLIFDPNSYLPKESMLKTTLTVFGLASLDLFEVGLEGKGFEPTLE
ALFGKQGFFPDSVNKALYWVNGRVPDGVSKVLVDHFGYTTGDKHEQDMVNGIMPIVDKLI
KDLKSKEIPEARAYLRILGKELSFVKLQDLQVLGKLLLNGAQTLQGIPQMVA-QAIREGS
KNDLFLHYIFMENAFELPTGAGLQLQVSSSGVFTPGIKAGVRLELA-NIQAELVAKPSAS
LEFVTNMGTIIPDFAKSGVQMNTNFFHESGLEARVALKAGQLKVIIPSPKRAVKLF

ENSGT00590000083139_0_Linker_3_5 (1017, 1044)

SGSN
TLHLVSTT----KTEVIPPLIEN

PF06448 // ENSGT00590000083139_0_Domain_5 (1044, 1156)

RQSWSTCKPFFTGMNYCTTG-AYSNASSTESASYYPL
TGDTRYELELRPTGEVEQYSATATYELLKEDKSLVDTLKFLVQAEGVQQSEATALFKYNR
RSRTLSSEVLIPGFD

ENSGT00590000083139_0_Linker_5_6 (1156, 4658)

VNFGTILRVKDESAKDKNTYKLILDIQNKKITEVSLMGHVSYDKN
GDGKIKGVVSVPRLQAEARSEVHTHWSPTKLLFQMDSS--AIAYGSTISKRVAWRYDNEK
IEFDWNTGTNVDTKKVASNFPV----DLSHYPRMLHEYASGLLDHRVPQTDVTFRHMGSK
LIVVTNTWLQMATRGLPYPQTLQDRLNSLSELNPLKMGLPDFHIPDNLFLNTNGRVKYTM
NKNRIKIDIPLPLGGKSSKDLKMPESVRTPALNFKSVGFHLPSREVQVPTFTIPKMHQLQ
VPLLGVLDLSTNFYSNLYNWSASYTGGNTSR-D--HFSLQAQYRMKADSVVDLFSYSLQG
SGETTYDSKNTFTLSCDGSLHHKF-LDSKFKVSHVEKFGNSPVSKGL---LTFETSSALG
PQMSATVHLDSKKKQHLYVKDITVDGQFRASSFYAQGKYDLSCERDVTTGQLRGESNMRF
NSTYFQGTSQIVGMYQDGTLSITSTSDLQDGIFKNTASLKYENYELTLKSDSSGQYENFA
TSNKLDMTFSTQSALLRSEHQANYKSLRLVTLLSGSLTSQGVELNADILGTDKINTGAHK
ATLKIARNGLSTSATSNLKYSPLLLVNELNAELGLSGASMKLSTSGRFKEHHATFSLDGR
AALTEVSLGSIYQAMILGADSKNIFNFKLSREGLRLSNDLMGSYAEMKLDHTHSLNIAGL
SLDFFSKMDNIYSGDKFYKQNFNLQLQPYSFVTTLNNDLRYNALDLTNSGRLRLEPLKLN
VGGNFKGTYQNNELKHIYTISYTDLVVASYRADT---VAKVQGMELSHRLNADIEGLTSS
VDVTTSYNSDPLHFNNVFHFALAPFILGIDTHTSGDGKLSFWGEHTGQLYSKFLLKAEPL
ALTASHEYKGSTSHNLPYKSSISTALEHTVSVLLTPAEQTSSWRFKTKLNDKVYSQDFEA
YNSKDKIGVELSGR--AELSGLNSPIKLPFFYSEPVNVLNGLEVNDAVDKPQEFAIVAMV
KYDKNQDVHTISLPFFKSLPDYLERNRRGIISLLEAVRGELQSVSVDQFVRKYRAALSKL
PQQIHDYLNASDWERQIAGAKERITSFMENYRITDNDVLIAIDNAKINFNEKLSQLETYA
IQFDQYIKDNYDPHDLKRTIAEIIDRIIEKLKILDEQYHIRVNLAKSIHNLYLFVENVDL
NQISSSSASWIQNVDTKYQIRIQIQEKLQQLRTQIQNIDIQQLAAEVKQQIEAIDVTMHL
DQLRTAFLFQRISDIIDRVKYFVMNLIEDFKVTEKINTFRVIVRELIEKYEVDQQIQVLM
DKSVELAHRYSLREPLQKLSNVLQQIEIKDYYEKLVGFIDDTVEWLKALSFKNTIEELNR
LIDMLVKKLKAFDYHQFVDKTNSKIREMTQKINAEIQALELPQKMEAL-KLLVEDLKTTV
SNSLERLKDTKVTVVIDWLQDIL-----AQMKDHFQDTLEDVRDRIYQMDIQWELERCLS
LVSQVYSTLATYLSDWWTLTAKNITDFAKQYSIQNWAESIKVLVEQGFIVPEMQTFLWTM
PAFEVSLRALQEGTFQTPDFIVPLTDLRIPSIRINLKMLRNIKIPLRFSTPEFTLLNTFH
VRSFTIDLLEIKAKVIRTIDQMLSSELQWPLPEVYLRDLDVVNIPLTRLTLPDFHVPEIT
IPEFTIPNINLKDLHIPDLHIPEFQLPRLSHTIEIPAFGKLHSILKIQSPLFVLDANANI
QNVTT-SENKAEIVASVTSRGQSQFEALNFDFQAQAQFLELNT--HPPVLKESMNFSSKH
VRMEHEGEIVFSGKAIEGKSDTVASLHTEKNAVEFNNGMTVKINNQLTLDSHTKYFHKLS
IPRLDFSSKASLNNEIKTLLEAGHVALTSSGTGSWNWACPNFSDEGIHSSQISFTVDGPI
ATFGLSNNINGKHLQVIQKLTYESGFLNYSKFEVESKVESQHVGSSILTAKGRALLRDAK
AEMTGEHNANLNGKVIGTLKNSLFFSAQPFEITASTNNEGNLKVSFPLKLTGKIDFLNNY
ALFLSPHAQQASWQASARFNQYKYNQNFSAINNEHNIEASMGMNGDANLDFLNIPLTIPE
IN--LPYMEFKTPL-LKDFSIWEETGLKDFLKTTKQSFDLSVKAQYKKNRDKHSIAIPLS
MFYEFILNNVNSWDRKFEKVRNNALHFLTASYNEAKIKVDKYKTENSLNQPSGTFQNRGY
TIPV---VNIKVSPFAVETLASSHVIPKAISTPSVTIPGPNIMVPSYRLVLP-SLELPVF
HGPGNLFKVFLPDFKGLSTIDNIYIPAMGNFTYDFSFKSSVITLNTNAGLYNQSDIVAHF
LSSSSFVTDALQYKLEGTSRLMRKRGLKLATAVSLA-NKFVKGSHDSTISLTKKNMEASM
RTTANLHVPVFTMNFKQELNGNTKSKPTVSSSIELNYDFNSSKLHSTAKGGIDHKFSLES
L-----TSYFSIESFTKGNVKGSFLS-REYSGSVTNEANAYLNSKGTRSSVRLQGASKVD
GIWNFEVGENFAGEATLRRIYATWEHNMKNHLQVDSYFFTKGKQTCRATLELSPWTMSTF
LQVHVSQPSSLLDLHHFDQEVILKANTKNQKVSWKSGVQVESQVLQHNAQFSNDQEEIRL
DLAGSLEGQLWDLETIFLPVYGKSLQELLQTD-----GKRQYLQASTSLLYTKNPNGYLL
SLPVQELADRFI--IPGLKLND-------------------------FSGIKIYKKLSTS
PFALNLTMLPKVKFPGVDLLTRYSKPEGSSVPIFEATIPEIHLTVSQFTLPKSFPVGNTV
FDLNKLANMIADVDLPSVTLPEQTIEVPPLQFSVPAGIFIPFFGELTARVGMASPLYNVT
WSAGWKTKADHVETFLDSTCTSTLQFLEYALKVVETHKIEEDMLTYNIKGTLQHCDFNVE
YNEDGLFKGLWDWQGEAHLDITSPALTDVHLHYKEDKT-SLSASAASSTVGTVGLDSSTD
D-QSVKLNV---YFH-PQSPPDKKLSIFKTEWR--YKESDGERYIKINWEEEAAS-RLLG
SLKSNVPKASKAIYDYANKYHLEYA-------SSELRKRLQDNAEH----ARRMVDEMN-
-MSFQRVAR---DTY-------QNLYEEML-AQKSQSSPENLKKRVLDSLVHVTQKYHMA
VTWLMDSFIHFLKFNRVQFPGYSGTYTADELYTIVMRETKKSLSQ----LFNGLGNLLSY
VQNQVEKSRLINDITFKCPFSPKPWK---------LKDLILICREYLN----ILSNIGQ-
-----QDIKF-TTILSSLQGFL-ERVLDIIEEQIKCLKDNESTCIADHINM-V---FKIQ
VPYAVKSLREDIHSVLSEFN----GFLQSILQEGSYKLQQVHQYMKALREEYFDPSMVGW
TVKYYEIEEKMVDLIRTLLVSLRDVYSEYSVTAADFASKMSTQVEQFVSRDIGDYLSMLA
DVNGKGMEKIAELSIVAKEAMKSWVTAVAEIMSDYPQ

PF12491 // ENSGT00590000083139_0_Domain_6 (4658, 4714)

QFHSNLQDFSEQLSSYYEKFVAE
STRLIDLSIQNYHVFLRYITELLKKLQV-ATGNNVSPYIKFAQGELMITF----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------

-----------------------------------------------MGPQRPALR----
-------PLLLLLSLLLFLDTSVWAQDEVPENFS-LNCPKDATR

PF01347 // ENSGT00590000083139_0_Domain_0 (105, 673)

FKHLRKYVYNYEAESS
SGVRGTADSRSATKINCKVELEVPQLCSFIMRTSQCTLKEVYGFNPEGKALMKKTKNSDE
FAAAMSRFEL-KLAIPEGKQVVLYPDKDEPKTILNIKRGIVSALLVPPETEEDKQVL---
FLDTVYGNCSTQVTVNSRKGTVATEMSTERS----LQQCDGFQPISTGVSPLALIKGLVH
PLSTLVSSSQSC-QYILDPKRKHVSEAICNEQHLFLPFSYKNKYGIMTHVTQTLSLEDTP
--KINSRFFSEG-TKRVGLAFESTKSTSPPKQ-ADAVLNTLQELKSLSVSEQNAQRANLF
NKLVTELRGLSDEAITSLLPQLIGVSS--PITLQALVQCGQPQCYTHILQWLKTEKAHPL
LVDMVTYLVALIPNPSTQRLREIFNTAKEQPSRATLYALSHVVNNYYD-ADHSGSPDL-Q
DIADYLLKQIDNECLGDEDHTYLILRVIGNMGRTMEQVMPALKSSVLNCVRSKKSSLLIQ
KAAVQALRKMELGEEVKEILFDTFVNGVAPVEKRLAAYLLLMKGPTSSDISKIIQLLQWE
QSEQVKNFVASH

ENSGT00590000083139_0_Linker_0_3 (673, 709)

IVNILNSEELYVQDLKNLIKDAPEYSQ-LPTIMDCK

PF09172 // ENSGT00590000083139_0_Domain_3 (709, 1017)

KFSRNYQISKSV
SLPSFD-PVSAKMEGNLIFDPNSYLPKESMLKTTLTVFGLASIDLFEIGLEGKGFEPTLE
ALFGKQGFFPDSVNKALYWVNGQVPDRVSKVLVDHFGYTNNGKHEQDMVNGIMPMVDKLI
RELKSKEIPEARAYLRILGEELGFVKLQDLQVLARLLLNGAQTLRGIPQMIA-QAIRDGS
KNDLFLHYIFMDNAFELPTGVGVQLQVSSSGVITPGTKAGVRMELA-NIQAELVAKPSVS
VEFVTNMGIIIPDFAKSGVQMNTNFFHESGLEARVALKAGQLKVTIPAPKRPVKLF

ENSGT00590000083139_0_Linker_3_5 (1017, 1044)

SGSN
TLHLVSTT----KMEVIPPLVEN

PF06448 // ENSGT00590000083139_0_Domain_5 (1044, 1156)

RQFWSTCKPFFTGMNYCTTG-AYSNASSTESASYYPL
TGDTRYELELKPTGEVEQYSASATYELLKEDKSLVDTLKFLVQAEGVQQTEATAVFKYNR
QSRTLSSEVLIPGFD

ENSGT00590000083139_0_Linker_5_6 (1156, 4658)

VDFGTILRVNDESSKDKNAYKLILDIQNRKITEVSLVGHVSYDKK
GDGKIKGVISVPHLQAEARSEIHTHWSLTKLLFQMDSS--ATAYGSTISKRVVWRYDNEK
IEFDWNAGTNVDTKKLASNFPV----DLSSYPRTLHEYADSLLDHRVPQTDMTFRHMGSK
LVVATNTWLQMASRGLPYSQKLQDHLNGLSELNLQKMGLPDFHIPDNLFLKSDGRIKYTL
NKNSIKLDIPLPFGGKSSKDLKIPENVKTPDLNFKAMGFHLPSQVFQVPTFTIPKTHQLQ
VPLLGVLDLSTNVYSNLYNWSASYTGGNTSR-D--HFSLRAQYRMKADSAVELFSYSMQG
SGETTYDNKNTFTLSCDGSLHHKF-LDSKFKVSHVEKFGNTPVSKGL---LTFEASSVLG
PQMSASVHLDSKKKQHLYVKDIKVDGKFRASLLYAQGKYGLSFERDPTTGQMNGESNMSF
NSTYFQGTNQIVGIYQDGTLSLTSTSDLQDGIFKNTASLKYENYELTLKSDSSGQYENFA
ASNKLDMTFSKQSASLRSEHQANYKSLRLVTLLSGSLTSQGVELNADILGTDKMNTGAHK
ATLKISRDGLSTSTTTNLKYSPLLLENELNAELGLSGASMKLSTNGRFKEHHAKFSVDGK
AALTEVSLGSIYQAMILGADSKNIFNFKLNQEGLKLSNDMMGSYAEMKLDHTHSLSIAGL
SLDLSSKMDNIYSADKFYKQNFNVHLQPYSFLTTLSNDLRYNALDLTNSGKLRLEPLKLN
VGGNFKGAYQNNELKHIYTISYTDLVVASYRADT---VAKVQGVEFSHRLNADIEGLASS
VDVTTNYDSEPLHFNNVFHFVLAPFTLGIDTHTSGDGKLSLWGEHTGQLYNKFLLKAEPL
ALTFSHDFKGSTNHDLVYKSSIGTGLEHMVSALLTPAEQTSTWKLNTRLNDKVYSQDFKA
YNTKDKIGVELSGR--ADLSGLYSPFKVPVFHSEPVSVLSDLEINDADSKPQEFTIVAFV
KYDKNQDVHTISLPFFKSLPEYLERNRRGIITLLEAMQGELQGINIDQFVRKYKAALSRL
PQQIRDHLNASDWERQVANAKEKLTAFMENYRITDNDVLIALDSAKINFNEKLSQLETYV
IQFDQYIRDNYDPQDLKKTIAQIIDRIIEKLKILDEQYHIRVNLEKSIHNLYVFVENVDL
NKIGSSTASWIQNVDTKYQIRIQIQEKLQQLRTQIQTIDIQQLAAELKQKIEAIDFTMHL
DQLRTSILFQRLNDIIEHVKYFVMNLLEDFKVTEKINTFRAIVHELIEKYEVDRQIQVLM
DKSVELVHRYSLGKTLQKLSNVLQQIEIKDYYEKCVGFIDDTIKWLKELSFKNFIEELNR
FLDMLVKKLKAFDYHQFINETNSKIREVTQRINAKIQALELPQKTEAL-KLLVEDFKATV
SDHLERLKDTKVTMFIDWLQAAL-----AHIKAHFQDTLEDVRDRLYRMDIQWELEHFLS
LVSQVYNTLVTYISDWWSLTAKNITDFAEQYSIQNWAESVKVLVEQGFTIPEIQTLLGTM
PAFEISLRALQEANFQTPDFTVPLTDLRIPSIRINLKMLKNVKIPSRFSTPEFTVLNTFH
VRSFTIDLLEIKAKIIRTIDQILSSEIQWPLPEVYLRDLEIVNIPLARLTLPDFHVPEMT
IPEFTIPNVSFKEFRVPDLHIPEFQLPRLSHTIEIPAFGRLHGILKIQSPLFILDANANI
QNVTT-LENKAEIVASIAATGESEIEALNFDFQAQAQFLELNP--NPLILKESMNFSSKH
ARMEHEGEILFSGKFIEGKLDTVASLQTEKNMVEFNNGMIVKINNQLILDSHTKYFHKLS
IPRLDFSSKASFNNEIKMLLEAGHVAWTSSGTGSWNWACPNFSDEGTHSSKISFTVEGPI
AFFGLSNNINGKHLRVIQKLAYESGFLNYSMLEVESKVESQHVGSSILTGKGTVLLREAK
AEMTGEHNADLNGKVIGTLKNSLSFSAQPFMITASTNNDGNLKVSFPLKLTGKIDFLNNY
ALFLSPHAQQASWQVSARFNQYKYNQNFSAINNEHNMEAHVGMNGDANLDFLTIPLTIPE
VK--LPYIGLTTPL-LKDFSIWEETGLKEFLKTTKQSFDLSVKAQYKKNRDRHSIAIPLN
GFYEFILNNVDSWDRKIGKVRDSALDYLISSYNEAKNKFE-----NSLIQPSRTFQKRGY
TIPF---VNIEVTPFTVETLASSHVIPKAINTPSVTILGPNVIVPSYRLVLP-SLELPVL
RVPRNLLKFSLPDFKELRTIDNIYIPALGNFTYDFSFKSSVITLNTNVGLYNRSDIVAHF
LSSSSFVTDALQYKLEGTSRLTRKRGLKLATAISLT-NKFVKGNHDSTFSLTKKNMEASV
KTTANLHAPILTMNFKQELNGNAKSKPIVSSSIELNYDFNSSKLYSTAKGGVDHKFSLES
L-----TSYFSIESSTKGNIKGSVLS-QEYSGSVASEANTYLNSKGTRSSVRLQGASKVD
GIWNLEVGENFAGEATLRRIYATWEHNNKNHLQVDSFFVTKGKQTCRATLELSPWTMSTL
LQVHVSQPSSLLDLHHFDQEVTLKANSKNQKVNWKSEVQIHSQVLQHNVQFSNDQEEVHL
DIAGSTDGQLWDLETIILPVYGKSLQELLKMD-----GKRQYLQASTSLVYTKNPNGYLF
SLPVQELADQFI--IPGLKLND-------------------------FSGIKIYKKLSTS
PFSLNLTMLPKVNFPGVDVLTQYSKQEDSSVPAFEVTIPEVRLTVSAFTLPK------TG
FALNDIVNRIADVDLPNITLPEQTIEVPPFRFSVPAGILIPFFGALTAHVGMASPVYNVT
WNAGLRNKEDHVETFLDSTCSSIWQFLEYDLKVVGTHKIEDHMFTCKNKGTLQHRDFSVE
YNEDGVFKGLWVWQGEAHLDITSPALTELRLLYKEDET-SLSTSVASPAIGTVGLESSTD
D-QSIKLNV---YFH-PQSPLERKLSIIKTEWR--YKKSDDGMHIKINWEEEAAS-RLLG
SLKSNMPKATEAIYDYVNKNYLGNA-------SLELRISLQNNVEN----AIRTIDEMN-
-MDFQRAAH---D--------TQNLYEEML-AQEVQSIPERLQEKALDSLVYVTQKYHTA
AMFLSDSFIHFLKYNTFHLPGNAGTYTADELCTLVMGETAKLLSH----IHNSLEKLLSF
VQDLVEKSGLINDIKFKFPFDSKMMK---------LKDAILEYRKLIN----SSS-----
------NTTF-TAILSYLRDFF-EVMLERIVEQVQCPSDKKSACFTDPIIA-I---FKTN
IQNAFIILREDIYPFFRDFN----DSVQSILQEGSYKLQQIHQYMKALREEYFDPSMVGW
TVKYYEVEEKMVDLITYLLVILRDFHSTYSARATDFASKITTEVEQFMSKDMQEYLSMLI
DMNEKGKEKIAELSITAMEAIKNWATAMKETIPDYQQ

PF12491 // ENSGT00590000083139_0_Domain_6 (4658, 4714)

QFSSKVQDLSDQLSDYCEKFIAE
SARLIGLSIQSYHMLLRYITELLKELQV-ATANNVSTYIKRAPGELIITF----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------

------------------------------------------------------------
-------------------KE----M---LENVS-PVCPRDTTR

PF01347 // ENSGT00590000083139_0_Domain_0 (105, 673)

FKHLRKYTYNYEAESS
SGVPGTADSRSATRINCKVELEVPQLCSFILKTSQCTLKEVYGFNPEGRALLKKTKNSEE
FAAAMSRYEL-KLVIPEGKQVFLYPEKDEPTHILNIKRGIISALLVPPETEETKQVL---
FLDTVYGNCSTHFTVKTRKGNVATEISTERD----LGQCDRFKPIRTGVSPLALIKGMTH
PLSTLISSSQSC-QYTLDAKRKHVAEAICKEQHLFLPFSYKNMYGMGVQVTQTLKLEDTP
--KINSRFFGEG-TKKVGLAFESTKSTSPPKQ-AEAVLKTLQELKKLTISEQNIQRANLF
HKLVTELRGLSDEAVTSLLPQLIEVSS--PITLQALVQCGQPQCSTHILQWLKRVHANPL
LIDVVTYLVALIPEPSAQQLREIFNMAREQRSRATLYALSHAVNNYHK-TNPTGTQEL-L
DIANYLMEQIQDDCTGDEDYTYLILRVIGNMGQTMEQLTPELKSSILKCVQSTKPSLMIQ
KAAIQALRKMEPKDEDQEVLLQTFLDDASPGDKRLAAYLMLMRSPSQADINKIVQLLPRE
QNEQVKNFVASH

ENSGT00590000083139_0_Linker_0_3 (673, 709)

IANILNSEELDIQDLKKLVKEALKESQ-LPTVMDFR

PF09172 // ENSGT00590000083139_0_Domain_3 (709, 1017)

KFSRNYRLSKSV
SLPSLD-PASAKIEGNLIFDPNNYLPKETMLKTTLTAFGFASADLFEIGLEGKGFEPTLE
ALFGKQGFFPDSVNKALYWVNGQVPDGVSKVLVDHFGYTKEDKREQDMVNGMMFTVQKLI
EDLKSKEVPEARAYLRILGEELGFARLHDLQLLGKLLLTGARTLQGIPQMIG-EVIRKGS
KNDFFLHYIFIENAFELPTGAGLQLQISSSGVTAPGIKAGVKLEVA-NMQAELVAKPSVS
VEFVTNMGIIIPDFARSGVQMNTNLFHESGLEARVALKAGQLKFIIPSPKRPVKLL

ENSGT00590000083139_0_Linker_3_5 (1017, 1044)

SGSN
TLHLVSTT----KTEVIPPLIEN

PF06448 // ENSGT00590000083139_0_Domain_5 (1044, 1156)

RQSLSVCKQLFTGLNYCTSS-AYSNASSTDSAPYYPL
TGDTRLELELRPTGEVEQYSVSATYELQREDRALVDTLKFVTQAEGVKQTEATMTFKYNR
QSMTLSSEVQIPDFD

ENSGT00590000083139_0_Linker_5_6 (1156, 4658)

VDLGTILRVNDESTEGRKSYRLTLDIQNKKITEVTLMGHLSCDTK
EEGKIKGVISVPRLQAEARSEIIAHWSPAKLLLQMDSS--ATAYGSTVSKRVAWHYDEEK
IEFEWNTGTNVDTKKMTSNFPV----DLSEYPRSLHMYADRLLDHRVPQTDMTFRHVGSK
LIVAMNSWLQKASGSLPYTQTLQDHLNSLKELNLQNMGLPDFHIPENLFLKSDGRVKYTL
NKNSLKVEIPLPFGGKSSRDLKMLETVRTPALHFTSVDFHLPSREFQVPTFTIPKLYQLQ
VPLLGVLDLSANVYSNLYNWSASYTGGNTST-D--HFSLQARYHMKADSVVDLLSYNVQG
SGEATYDHKNTFTLSCGGSLRHKF-LDSSIKFSHVEKLGNNPVSKGL---LIFDASSSWG
PQMSASVHMDSKKEQHLFVKEVKIDGQFRVSSFYAKGTYGLSCQRDPNTGRLNGESNLRF
NSSYLQGTNQITGRYEDGTLSLISTSDLQSGIIKNTASLKYENYELTLKSDTNGKYENFA
TSNKMDMTFSKQNALLRSEYQADYESLRFFSLLSGSLNSHGLELNADILGTDKINSGAHK
ATLRTGQDGVSTSATTNLKYSPLVLENELNAEIGLSGASMKLTTNGRFREHNAKFSLDGK
AALTELSLGSAYQAMILGVDSKNIFNFKISQEGLKLSNDMMGSYAEMKFDHTNSLNIAGL
SLDFSSKLDNIYSSDKFYKQTFNLQLQPYSLVTTLNNDLKYNALDLTNNGKLRLEPLKLH
MAGNLKGAYQNNEIKHIYTISSAALS-ASYKADT---VAKVQGVEFSHRLNTDIAGLASA
IDISTNYNSDSLHFSNVFHSVMAPFTMTIDTHTNGNGKLALWGEHTGQLYSKFLLKAEPL
AFTFSHDYKGSTSHHLMSRKSISTSLEHKVSALLTPAEQTGTWKLKTQFNNNEYSQDLDA
YNTKDKIGVELSGRALADLTLLDYPIEVPLLLSEPVNVIDALEMRDAVEKPQEFTIVAFV
KYDKNQDVHTINLPFFETLQEYFERNQRTIIVVLENMQRHLKRINIDQFVRKYRAALGKL
PQQANDYLNSFNWERQVSRAKEKLTALTKKYRITENDIQIALDDAKINFNEKLSQLQTYM
IQFDQYIKDNYDLHDLKIAIANIIDQIIEKLKSLDEHYHIRVNLVKTIHDLHLFIENIDF
NKIGSSTASWIQNVDTKYQIRIRIQEKLQQLKRHIQNIDIQHLAGKLKQHVEAIDVRVLL
DQLGTTISFERINDVLEYVKHFVINLIGDFEVAEKINAFRAKVHELIERYEVDQQIQVLM
DKLVELAHQYKLKETIQKLSNVLQQVKIKDYFEKLVGFIDDAVKQLDELSFKTFIEDVNK
FLDMLIKKLKSFDYHQFVDETNNKIRELTQRLNGEIQALELPQKAEAL-KLFLQETKATV
AMYLESLQDTKITLIIDWLQDALSSASLAHMKAKFRETLEDTRDRIYQMDIKQELQRYLS
LVGQVYSTLVTYISDWWTLAAKNLTDFAEQYSIQDWAKHVKALVEQGFTVPEIKTILGTM
PAFEVSLQALQKATFQTPDFIVPLTDLRIPSVQINFKELKDIKIPSRFSTPEFTILNTFH
IPSFTIDFVEIKVKIIRTIDQMLNSELQWPVPEVYLRDLKVENIPLARITLPDFHLPEIA
IPEFVIPNLNLNDFQVPDLHIPEFQLPHISHTIEVPTFGKLYSILKIQSPLFTLDANADI
GNGTT-SANEAGIAASITAKGESKLEVLNFDFQANAQLSNPKI--NPLALKEFVKFSSKY
LRTEHGSEMLFFGNAIEGKSNTVASLHTEKNTLELSNEVIVKINNQLTLDSNTKYFHKLN
IPKLDFSSQADLRNEIKTLLEAGHIAWTSSGKGSWKWACPRFSDEGTHESQISFTIEGPL
TSFGLSNKINSKHLRVNQNLVYESGSLNFSKLEIQSQVDSQHVGHSVLTAKGTALFGEGK
AEFTGRHDAHLNGKVIGTLKNSLFFSAQPFEITTSTNNEGNLKVSFPLRLTGKIDFLNNY
ALFLSPSAQQASWQVSTRFNQYKYNQNFSAGNNKNIMEAHIGINGEANLDFLNIPLTIPE
MP--LPYTTITTPP-LKDFSLWEKTGLKEFLKTTKQSFDLSVKAQYKKNTHRHSITNPLA
VLYEFTSQNIKSFDKHFEKARNNALGFVTKSYNDAKIKFDKYKAEKSHDELPRTFQIPGY
TVPV---VNVEVSPFTVEMSAFGYGIPKAVSMPSFTILGSNIRVPSYTLILP-SLELPVL
QVPRNL-KLSLPDFKELCTISHIFIPAMGNITFDFSFKSSVISLNTNAEVFNQSDIVAHL
LSSSSSVIDVLQYKLEGTTRLTRKRGLKLATALSLS-NKFVEGSHNSTVSLTKKNMEASV
ATTAKVQIPILRINFKQELNGNTKSKPTVSSSMEFKYDFNSSMLYSTAKGAVDHKLILES
L-----TSYFSIESSTKGDVKGSVLS-RDYSGTIASEANTYLNSKSTRSSVKLQGTSKID
DIWNLDVKENFAGEATLQRIYYLWEHSMKNHLKLEGLFFTNGEHTSKATLELSPWEMSAF
VQVHASQPNSFLDIPHLGQEVALNANTKNQKIRWKNEVRVHSGSFQNHVELSNDQEKAHL
DIAGSLEGHLRFLKNIILPVYGKSLWDFLKLDVTTSIGRRQHLRVSTAFVYTKNPDGYSF
SIPVKVLADEFI--IPGLKLNDLNSVLVMPTFHVPFTDLQVPSYKLDFREIKIYKKLRTS
SFALNLPALPEVKFPEVDVLTKYSQPEDSLIPFFEITVPESQLTVSQFTLPKSVSVGSAV
LDLNAVANKIADFELPTIIMPEQTIEIPSIKFSVPAGIFIPSFQALTARFEVDSPLYNAT
WSASLKNKADHVETVLDSMCSSIMQFLEYKLNVVGTHRIEDGMLASKTKGTFAHHDFSAE
YEEDGKYKGLREWERKVHLDIKSPAFTDLHLRYQKDKK-GVSTSAASPAIGTMGMDV---
--DFSKWNI---YYS-PQSSPDKKLTIFKTELR--FRESDEEIQIKVNWEEEAAS-GLLT
SLKDNVPKATGALYDYVNKYHWEHTGLTLREASSKLRRNLQNNAEWVYQGAIRQIDDID-
-LRFQKAASGTTGTYQEWKDKAQNLYQELL-TQEGQTSFQGLKDKVFDGLVRVTQEFHTK
VKHLIDSLIDFLNFPRFQFPGKPGTYTGEELCTMFLREVGMVLSQVCLKVHNGSEILFSY
FQDLV----------ITLPFELRRHK---------LIDVISMCRERLK----VLSEEAQE
VFKDIQSLKT-TEVLRNLQDVL-QFIFQLIEDNIKQLKEMKFTHLINYIQDEINTIFNDY
IPYVFKLLKENLCLNLHKFN----EFIQNELQGASQELQQIHQYIMALREEYFDPSVVGW
TVKYYELEEKIVRLIKNLLVALKDFHSEYIVSASDFTSQLSSQVEQFLHRNIQEYLSILT
DPDGKGKDKIAELSTTAQEIIKSQTIAMKEIISDYHQ

PF12491 // ENSGT00590000083139_0_Domain_6 (4658, 4716)

QFRYKLQDFSDQLSDYYEKFIAE
SKRLIDLSIQNYHTFLIYIMELLKKLQS-TTV--MNPYVKLAPGELTIIL----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------

-----------------------------------------------MDPPRPALL----
ALLALPALLLLLLAGARAEEE----M---LENVS-LVCPKDATR

PF01347 // ENSGT00590000083139_0_Domain_0 (105, 673)

FKHLRKYTYNYEAESS
SGVPGTADSRSATRINCKVELEVPQLCSFILKTSQCTLKEVYGFNPEGKALLKKTKNSEE
FAAAMSRYEL-KLAIPEGKQVFLYPEKDEPTYILNIKRGIISALLVPPETEEAKQVL---
FLDTVYGNCSTHFTVKTRKGNVATEISTERD----LGQCDRFKPIRTGISPLALIKGMTR
PLSTLISSSQSC-QYTLDAKRKHVAEAICKEQHLFLPFSYKNKYGMVAQVTQTLKLEDTP
--KINSRFFGEG-TKKMGLAFESTKSTSPPKQ-AEAVLKTLQELKKLTISEQNIQRANLF
NKLVTELRGLSDEAVTSLLPQLIEVSS--PITLQALVQCGQPQCSTHILQWLKRVHANPL
LIDVVTYLVALIPEPSAQQLREIFNMARDQRSRATLYALSHAVNNYHK-TNPTGTQEL-L
DIANYLMEQIQDDCTGDEDYTYLILRVIGNMGQTMEQLTPELKSSILKCVQSTKPSLMIQ
KAAIQALRKMEPKDKDQEVLLQTFLDDASPGDKRLAAYLMLMRSPSQADINKIVQILPWE
QNEQVKNFVASH

ENSGT00590000083139_0_Linker_0_3 (673, 709)

IANILNSEELDIQDLKKLVKEALKESQ-LPTVMDFR

PF09172 // ENSGT00590000083139_0_Domain_3 (709, 1017)

KFSRNYQLYKSV
SLPSLD-PASAKIEGNLIFDPNNYLPKESMLKTTLTAFGFASADLIEIGLEGKGFEPTLE
ALFGKQGFFPDSVNKALYWVNGQVPDGVSKVLVDHFGYTKDDKHEQDMVNGIMLSVEKLI
KDLKSKEVPEARAYLRILGEELGFASLHDLQLLGKLLLMGARTLQGIPQMIG-EVIRKGS
KNDFFLHYIFMENAFELPTGAGLQLQISSSGVIAPGAKAGVKLEVA-NMQAELVAKPSVS
VEFVTNMGIIIPDFARSGVQMNTNFFHESGLEAHVALKAGKLKFIIPSPKRPVKLL

ENSGT00590000083139_0_Linker_3_5 (1017, 1044)

SGGN
TLHLVSTT----KTEVIPPLIEN

PF06448 // ENSGT00590000083139_0_Domain_5 (1044, 1156)

RQSWSVCKQVFPGLNYCTSG-AYSNASSTDSASYYPL
TGDTRLELELRPTGEIEQYSVSATYELQREDRALVDTLKFVTQAEGAKQTEATMTFKYNR
QSMTLSSEVQIPDFD

ENSGT00590000083139_0_Linker_5_6 (1156, 4658)

VDLGTILRVNDESTEGKTSYRLTLDIQNKKITEVALMGHLSCDTK
EERKIKGVISIPRLQAEARSEILAHWSPAKLLLQMDSS--ATAYGSTVSKRVAWHYDEEK
IEFEWNTGTNVDTKKMTSNFPV----DLSDYPKSLHMYANRLLDHRVPQTDMTFRHVGSK
LIVAMSSWLQKASGSLPYTQTLQDHLNSLKEFNLQNMGLPDFHIPENLFLKSDGRVKYTL
NKNSLKIEIPLPFGGKSSRDLKMLETVRTPALHFKSVGFHLPSREFQVPTFTIPKLYQLQ
VPLLGVLDLSTNVYSNLYNWSASYSGGNTST-D--HFSLRARYHMKADSVVDLLSYNVQG
SGETTYDHKNTFTLSCDGSLRHKF-LDSNIKFSHVEKLGNNPVSKGL---LIFDASSSWG
PQMSASVHLDSKKKQHLFVKEVKIDGQFRVSSFYAKGTYGLSCQRDPNTGRLNGESNLRF
NSSYLQGTNQITGRYEDGTLSLTSTSDLQSGIIKNTASLKYENYELTLKSDTNGKYKNFA
TSNKMDMTFSKQNALLRSEYQADYESLRFFSLLSGSLNSHGLELNADILGTDKINSGAHK
ATLRIGQDGISTSATTNLKCSLLVLENELNAELGLSGASMKLTTNGRFREHNAKFSLDGK
AALTELSLGSAYQAMILGVDSKNIFNFKVSQEGLKLSNDMMGSYAEMKFDHTNSLNIAGL
SLDFSSKLDNIYSSDKFYKQTVNLQLQPYSLVTTLNSDLKYNALDLTNNGKLRLEPLKLH
VAGNLKGAYQNNEIKHIYAISSAALS-ASYKADT---VAKVQGVEFSHRLNTDIAGLASA
IDMSTNYNSDSLHFSNVFRSVMAPFTMTIDAHTNGNGKLALWGEHTGQLYSKFLLKAEPL
AFTFSHDYKGSTSHHLVSRKSISAALEHKVSALLTPAEQTGTWKLKTQFNNNEYSQDLDA
YNTKDKIGVELTGRTLADLTLLDSPIKVPLLLSEPINIIDALEMRDAVEKPQEFTIVAFV
KYDKNQDVHSINLPFFETLQEYFERNRQTIIVVLENVQRNLKHINIDQFVRKYRAALGKL
PQQANDYLNSFNWERQVSHAKEKLTALTKKYRITENDIQIALDDAKINFNEKLSQLQTYM
IQFDQYIKDSYDLHDLKIAIANIIDEIIEKLKSLDEHYHIRVNLVKTIHDLHLFIENIDF
NKSGSSTASWIQNVDTKYQIRIQIQEKLQQLKRHIQNIDIQHLAGKLKQHIEAIDVRVLL
DQLGTTISFERINDILEHVKHFVINLIGDFEVAEKINAFRAKVHELIERYEVDQQIQVLM
DKLVELAHQYKLKETIQKLSNVLQQVKIKDYFEKLVGFIDDAVKKLNELSFKTFIEDVNK
FLDMLIKKLKSFDYHQFVDETNDKIREVTQRLNGEIQALELPQKAEAL-KLFLEETKATV
AVYLESLQDTKITLIINWLQEALSSASLAHMKAKFRETLEDTRDRMYQMDIQQELQRYLS
LVGQVYSTLVTYISDWWTLAAKNLTDFAEQYSIQDWAKRMKALVEQGFTVPEIKTILGTM
PAFEVSLQALQKATFQTPDFIVPLTDLRIPSVQINFKDLKNIKIPSRFSTPEFTILNTFH
IPSFTIDFVEMKVKIIRTIDQMLNSELQWPVPDIYLRDLKVEDIPLARITLPDFRLPEIA
IPEFIIPTLNLNDFQVPDLHIPEFQLPHISHTIEVPTFGKLYSILKIQSPLFTLDANADI
GNGTT-SANEAGIAASITAKGESKLEVLNFDFQANAQLSNPKI--NPLALKESVKFSSKY
LRTEHGSEMLFFGNAIEGKSNTVASLHTEKNTLELSNGVIVKINNQLTLDSNTKYFHKLN
IPKLDFSSQADLRNEIKTLLKAGHIAWTSSGKGSWKWACPRFSDEGTHESQISFTIEGPL
TSFGLSNKINSKHLRVNQNLVYESGSLNFSKLEIQSQVDSQHVGHSVLTAKGMALFGEGK
AEFTGRHDAHLNGKVIGTLKNSLFFSAQPFEITASTNNEGNLKVRFPLRLTGKIDFLNNY
ALFLSPSAQQASWQVSARFNQYKYNQNFSAGNNENIMEAHVGINGEANLDFLNIPLTIPE
MR--LPYTIITTPP-LKDFSLWEKTGLKEFLKTTKQSFDLSVKAQYKKNKHRHSITNPLA
VLCEFISQSIKSFDRHFEKNRNNALDFVTKSYNETKIKFDKYKAEKSHDELPRTFQIPGY
TVPV---VNVEVSPFTIEMSAFGYVFPKAVSMPSFSILGSDVRVPSYTLILP-SLELPVL
HVPRNL-KLSLPDFKELCTISHIFIPAMGNITYDFSFKSSVITLNTNAELFNQSDIVAHL
LSSSSSVIDALQYKLEGTTRLTRKRGLKLATALSLS-NKFVEGSHNSTVSLTTKNMEVSV
ATTTKAQIPILRMNFKQELNGNTKSKPTVSSSMEFKYDFNSSMLYSTAKGAVDHKLSLES
L-----TSYFSIESSTKGDVKGSVLS-REYSGTIASEANTYLNSKSTRSSVKLQGTSKID
DIWNLEVKENFAGEATLQRIYSLWEHSTKNHLQLEGLFFTNGEHTSKATLELSPWQMSAL
VQVHASQPSSFHDFPDLGQEVALNANTKNQKIRWKNEVRIHSGSFQSQVELSNDQEKAHL
DIAGSLEGHLRFLKNIILPVYDKSLWDFLKLDVTTSIGRRQHLRVSTAFVYTKNPNGYSF
SIPVKVLADKFI--IPGLKLNDLNSVLVMPTFHVPFTDLQVPSCKLDFREIQIYKKLRTS
SFALNLPTLPEVKFPEVDVLTKYSQPEDSLIPFFEITVPESQLTVSQFTLPKSVSDGIAA
LDLNAVANKIADFELPTIIVPEQTIEIPSIKFSVPAGIVIPSFQALTARFEVDSPVYNAT
WSASLKNKADYVETVLDSTCSSTVQFLEYELNVLGTHKIEDGTLASKTKGTFAHRDFSAE
YEEDGKYEGLQEWEGKAHLNIKSPAFTDLHLRYQKDKK-GISTSAASPAVGTVGMDMDED
D-DFSKWNF---YYS-PQSSPDKKLTIFKTELR--VRESDEETQIKVNWEEEAAS-GLLT
SLKDNVPKATGVLYDYVNKYHWEHTGLTLREVSSKLRRNLQNNAEWVYQGAIRQIDDID-
-VRFQKAASGTTGTYQEWKDKAQNLYQELL-TQEGQASFQGLKDNVFDGLVRVTQEFHMK
VKHLIDSLIDFLNFPRFQFPGKPGIYTREELCTMFIREVGTVLSQVYSKVHNGSEILFSY
FQDLV----------ITLPFELRKHK---------LIDVISMYRELLK----DLSKEAQE
VFKAIQSLKT-TEVLRNLQDLL-QFIFQLIEDNIKQLKEMKFTYLINYIQDEINTIFSDY
IPYVFKLLKENLCLNLHKFN----EFIQNELQEASQELQQIHQYIMALREEYFDPSIVGW
TVKYYELEEKIVSLIKNLLVALKDFHSEYIVSASNFTSQLSSQVEQFLHRNIQEYLSILT
DPDGKGKEKIAELSATAQEIIKSQAIATKKIISDYHQ

PF12491 // ENSGT00590000083139_0_Domain_6 (4658, 4716)

QFRYKLQDFSDQLSDYYEKFIAE
SKRLIDLSIQNYHTFLIYITELLKKLQS-TTV--MNPYMKLAPGELTIIL----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------

-----------------------------------------------MGPPRPALL----
AL---PALL-LLLAGARAEKE----M---LENVS-PVCPRDTTR

PF01347 // ENSGT00590000083139_0_Domain_0 (105, 673)

FKHLRKYTYNYEAESS
SGVPGTADSRSATRINCKVELEVPQLCSFILKTSQCTLKEVYGFNPEGRALLKKTKNSEE
FAAAMSRYEL-KLVIPEGKQVFLYPEKDEPTHILNIKRGIISALLVPPETEETKQEL---
FLDTVYGNCSTHFTVKTRKGNVATEISTERD----LGQCDHFKPIRTGVSPLALIKGMTH
PLSTLISSSQSC-QYTLDAKRKHVAEAICKEQHLFLPFSYKNMYGMGVQVTQTLKLEDTP
--KINSRFFGEG-TKKVGLAFESTKSTSPPKQ-AEAVLKTLQELKKLTISEQNIQRANLF
HKLVTELRGLSDEAVTSVLPQLIEVSS--PITLQALVQCGQPQCSTHILQWLKRVHANPL
LIDVVTYLVALIPEPSAQQLREIFNMAREQRSRATLYALSHAVNNYHK-TNPTGTQEL-L
DIANYLMEQIQDDCTGDEDYTYLILRVIGNMGHTMEQLTPELKSSILKCVQSTKPSLMIQ
KAAIQALRKMEPKDEDQEVLLQTFLDDASPGDKRLAAYLMLMRSPSQADINKIVQLLPRE
QNEQVKNFVASH

ENSGT00590000083139_0_Linker_0_3 (673, 709)

IANILNSEELDIQDLKKLVKEALKESQ-LPTVMDFR

PF09172 // ENSGT00590000083139_0_Domain_3 (709, 1025)

KFSRNYQFSKSV
SLPSLD-PASAKIEGNLIFDPNNYLPKETMLKTTLTAFGFASADLFEIGLEGKGFEPTLE
ALFGKQGFFPDSVNKALYWVNGQVPDGVSKVLVDHFGYTKEDKREQDMVNGMMFTVKKLI
EDLKSKEVPEARAYLRILGEELGFARLHDLQLLGKLLLTGARTLQGIPQMIG-EVIRKGS
KNDFFLHYIFIENAFELPTGAGLQLQISSSGVTAPGIKAGVKLEVA-NMQAELLAKPSVS
VEFVTNMGIIIPDFARSGVQMNTNFFHESGLEARVALKAGQLKFIIPSPKRPVKLLSGSN
TLHL

ENSGT00590000083139_0_Linker_3_5 (1025, 1042)

VSTT----KTEVIPPLI

PF06448 // ENSGT00590000083139_0_Domain_5 (1042, 1156)

ENRQSLSVCKQLFTGLNYCTSS-AYSNASSTDSAPYYPL
TGDTRLELELRPTGEVEQYSVSATYELQREDRALVDTLKFVTQAEGVKQTEATMTFKYNR
QSMTLSSEVQIPDFD

ENSGT00590000083139_0_Linker_5_6 (1156, 4658)

VDLGTILRVNDESTEGRKSYRLTLDIQNKKITEVTLMGHLSCDTK
EEGKIKGVISIPRLQAEARSEILAHWSPAKLVLQMDSS--ATAYGSTVSKRVAWHYDEEK
IEFEWNTGTNVDTKKMTSNFPV----DLSEYPRSLHMYADRLLDHRVPQTDMTFRHVGSK
LIVAMNSWLQKASEILPYTQTLQDHLNSLKELNLQNMGLPDFHIPENLFLKSDGRVKYTL
NKNSLKVEIPLPFGGKSSRDLKMLETVRTPALHFKSVDFHLPSREFQVPTFTIPKLYQLQ
VPLLGVLDLSANVYSNLYNWSASYTGGNTST-D--HFSLQARYHMKADSVVDLLSYNVQG
SGEATYDHKNMFTLSCGGSLRHKF-LDSNIKFSHVEKLGNNPVSKGL---LIFDASSSWG
PQMSASVHLDSKKEQHLFVKEVKIDGQFRVSSFYAKGTYGLSCQRDPNTGRLNGESNLRF
NSSYLQGTNQITGRYEDGTLSLISTSDLQSGIIKNTASLKYENYELTLKSDTNGKYENFA
TSNKMDMTFSKQNALLRSEYQADYESLRFFSLLSGSLNSHGLELNADILGTDKINSGAHK
ATLRIGQDGVSTSATTNLKYSPLVLENELNAEIGLSGASMKLTTNGRFREHNAKFSLDGK
AALTELSLGSAYQAMILGVDSKNIFNFKISQEGLKLSNDMMGSYAEMKFDHTNSLNIAGL
SLDFSSKLDNIYSSDKFYKQTFNLQLQPYSLVTTLNNDLKYSALDLTNNGKLRLEPLKLH
VAGNLKGAYQNNEIKHIYTISSAALS-ASYKADT---VAKVQGVEFSHRLNTDIAGLASA
IDISTNYNSDSLHFSNVFHSVMAPFTMTIDTHTNGNGKLALWGEHTGQLYSKFLLKAEPL
AFTFSHDYKGSTSHHLMSRKSISTSLEHKVSALLTPAEQTGTWKLKTQFNNNEYSQDLDA
YNTKDKIGVELSGRALADLTLLDYPIEVPLLLIEPVNVIDALEMRDAVEKPQEFTIVAFV
KYDKNQDVHTINLPFFETLQEYFERNQRTIIVVLESMQRHLKHINIDQFVRKYRAALGKL
PQQANDYLNSFNWERQVSRAKEKLTALTKKYRITENDIQTALDDAKINFNEKLSQLQTYM
IQFDHYIKDNYDLHDLKIAIANIIDQIIEKLKSLDEHYHIRVNLVKTIHDLHLFIENIDF
NKIGSSTASWIQNVDTKYQIRIRIQEKLQQLKRHIQNIDIQHLAGKLKQHIEAIDVRVLL
DQLGTTISFERINDVLEHVKHFVINLIGDFEVTEKINAFRAKVHELIERYEVDQQIQVLM
DKLVELAHQYKLKETIQKLSNVLQQVKIKDYFEKLVGFIDDAVKQLDELSFKTFIEDVNK
FLDMLIKQLKSFDYHQFVDETNNQIRELTQRLNGEIQALELPQKAEAL-KLFLEETKATV
AVYLESLQDTKITLIIDWLQDALSSASLAHMKAKFRETLEDTRDRIYQMDIEQELQRYLS
LVGQVYSTLVTYISDWWTLAAKNLTDFAEQYSIQDWAKHVKALVEQGFTVPEIKTILGTM
PAFEVSLQALQRATFQTPDFIVPLTDLRIPSVQINFKELKDIKIPSRFSTPEFTILNTFH
IPSFTIDFVEIKVKIIRTIDQMLNSELQWPVPEVYLRDLKVEDIPLARITLPDFHLPEIA
IPEFVIPNLNLNDFQVPDLHIPEFQLPHISHTIEVPTFGKLYSILKIQSPLFTLDANADI
GNGTT-SANEAGIAASITAKGESKLEVLNFDFQANAQLSNPKI--NPLALKEFVKFSSKY
LRTEHGSEMLFFGNVIEGKSNTVASLHTEKNTLELSNEVIVKINNQLTLDSNTKYFHKLN
IPKLDFSSQADLRNEIKTLLEAGHIAWTSSGKGSWKWACPRFSDEGTHESQISFTIEGPL
TSFGLSNKINSKHLRVNQNLVYESGSLNFSKLEIQSQVDSQHVGHSVLTAKGTALFGEGK
AEFTGRHDAHLNGKVIGTLKNSLFFSAQPFEITTSTNNEGNLKVSFPLRLTGKIDFLNNY
ALFLSPSAQQASWQVSTRFNQYKYNQNFSAGNNKNIMEAHVGINGEANLDFLNIPLTIPE
MP--LPYTIITTPP-LKDFSLWEKTGLKEFLKTTKQSFDLSVKAQYKKNKHRHSITNPLA
VLYEFTSQNIKSFDKHFEKARNNALDFVTKSYNDAKIKFDKYKAEKSHDELPRTFQIPGY
TVPV---VNVEVSPFTVEMSAFGYGIPKAVSMPSFTILGSDIHVPSYTLILP-SLELPVL
QVPRNL-KLSLPDFKELCTISHIFIPAMGNITFDFSFKSSVISLNTNAEVFNQSDIVAHL
LSSSSSVIDVLQYKLEGTTRLTRKRGLKLATALSLS-NKFVEGSHNSTVSLTKKNMEASV
ATTAKVQIPILRINFKQELNGNTKSKPTVSSSMEFKYDFHSSMLYSTAKGAVDHKLILES
L-----TSYFSIESSTKGDVKGSVLS-RDYSGTIASEANTYLNSKSTRSSVKLQGTSKID
DIWNLEVKENFAGEATLQRIYSLWEHSMKNHLKLEGLFFTNGEHTSKATLELSPWEMSAF
VQVHASQPNSFLDIPHLGQEVTLNANTKNQKIRWKNEARVHSGSFQNHVELSNDQEKAHL
DIAGSLEGNLRFLKNIILPVYGKSLWDFLKLDVTTSIGRRQHLRVSTAFVYTKNPNGYSF
SIPVKVLADEFI--IPGLKLNDLNSVLVMPTFHVPFTDLQVPSYKLDFREIKIYKKLRTS
SFALNLPALPEVKFPEVDVLTKYSQPEDSLIPFFEITVPESQLTVSQFTLPKSVSVGSAV
LDLNAVANKIADFELPTIIMPEQTIEIPSIKFSVPAGIFIPSFQALTARFEVDSPLYNAT
WSASLKNKADHVETVLDSTCSSTIQFLEYKLNVVGTHRIEDGMLASKTKGTFAHHDFSAE
YEEDGKYEGLREWERKVHLDIKSPAFTDLHLRYQKDKK-GVSTSAASPTIGTMGMDV---
--DFSKWNI---YYI-PQSSPDKKLTIFKTELR--FQESDEEIQIKVNWEEEAAS-DLLT
SLKDNVPKATGALYDYVNKYHWEHTGLTLREASSKLRRNLQNNAEWVYQGSIRQIDDID-
-LQFRKAASGTTGTYQEWKDKAQNLYQELL-TQEGQTSFQGLKDKVFDGLVRVTQEFHTK
VKHLIDSLIDFLNFPRFQFPGKPGTYTGEELCTTFIREVGMVLSQVYLKVHNGSEILFSY
FQDLV----------ITLPFELRRHK---------LIDVISMYREWLK----VLSKEAQE
VFKDIQSLKT-TEVLRNLQDLL-QFIFQLIEDNIKQLKEMKFTDLINYIQDEINIIFNDY
IPYVFKLLKENLCLNLHKFN----EFIQNELQGASQELQQIHQYIMALREEYFDPSVVGW
TVKYYELEEKIVRLIKNLLVALKDFHSEYIVSASDFTSQLSSQVEQFLHRNIQEYLSILT
DPDGKGKEKIAELSTTAQEIIKSQAIAMKEIISDYHQ

PF12491 // ENSGT00590000083139_0_Domain_6 (4658, 4717)

QFRYKLQDFSDQLSDYYEKFIAE
SKRLIDLSIQNYHTFLIYIMELLKKLQS-TTV--MNPYVKLAPGELTIIL----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------

-----------------------------------------------MGAPRP-------
------AVLL-LLLLLFLDAANAQARDEVLENVS-PSCPKDAVR

PF01347 // ENSGT00590000083139_0_Domain_0 (105, 673)

FKHLRKYVYNYEAESS
SGVPGTADSRSATKINCKVELEVPQLCNFILKTSDCTLKEVDGLNPEGKALLKKTKNSEE
FAAAMSKYDL-KLAVPEGKQVLLYPEKEEPKHILNIKRGIISALLLPPETEEAKQVL---
FLDTVYGNCSTDFTVKTKKGNVATEISIERN----LEKCDHFQPISTGVSPLALIRGMTR
PLSTLIGSSQSC-RYTLDPRKKHVSEAICNEQHLFLPFSYKNKYGMMAQVTQTLKLENTP
--KINSRFFEEG-TEAVGLAFESTRSTSPPNH-AEAIVKTLQELQKLHVSEQNAQRANLF
HKLVTELRGLSSEAVTSLLPKLIEVSS--PITLQALIQCGQPQCYTHILQWLKNERANPL
LIDAVTYLVALIPEPSAERLREVFNTARVQQSRLTFYALSHMINNYHK-TNPTWTQDL-L
EIADYLSEQIGNDCTGNEDLTYLILRVIGNIGKTMEQLTPKLTSSVLKCIRSEQPSLVIQ
KAAIQALRKMELSDEVREVLLQTFLDDTSPGDKRLAAYLMLMGSPSQSDISKITQLLSGE
QNEQVKNFVASH

ENSGT00590000083139_0_Linker_0_3 (673, 709)

IANILNSEDLYVQDLKSLVEEALKKSQ-LPTIMDFK

PF09172 // ENSGT00590000083139_0_Domain_3 (709, 1025)

KFSRSYQFSKSI
SLPSLD-LVSAKIEGNLIFDPNNYLPKESMLKTTLKVFGFASADLFEIGLEGKGFEPTLE
ALFGKEGFFPDSVNKALYWVNGRVPDRVSKVLVDHFGYTKDDKHEQDMVNGVMFNVEKLV
KDLKSKDFPEARAYLRILGEELGFVKLHDLQLLGKLLLKGVRTLQGIPQMIK-ELIRKGS
TSDLFLHYIFMDNAFELPTGLGLQLQVSSSGIITPGIKAGVKLEVA-DIESEISQKPSQT
SQFVQTIRCIIPSHAKSGLQLQPHFKAGEGNEAHVYIRRGRMKYKIKSFKRATGILSYSN
TLHL

ENSGT00590000083139_0_Linker_3_5 (1025, 1042)

VSTT----KTEVIPPLI

PF06448 // ENSGT00590000083139_0_Domain_5 (1042, 1156)

ENRQSWSTCKPFFIGLNYCITG-AYSNASSTDSSSYYPL
TGDTRFELELKPTGEVEQYSAKAFYELRRDGEALVDMLKLVTQTEGVKQTEATLLFRYNR
QSKTLSSELHIPDFD

ENSGT00590000083139_0_Linker_5_6 (1156, 4658)

IDLGTVLKVNYEHSKEKKSYKLTLDFQNKKITEVTLTGHISYDRK
EEGKIKGVISIPRLQAEARSEILSLWSPSKLLLQMDSS--ATAYGSTISKKVAWRYDGDK
IEFEWNTGTNVDTKKATSNFPV----DLSAFPKSLHTYANILLDRRVPQTDLTFRHMGSK
LVAAASTWLQETSRSLPYAQNIQDQLSGLQELCLQKMELPNFHIPDNLFLKSDGRIKYTL
NKNSMEIEIPLPFGGKSSEDLKMFKTIQTPALNFQPLGFHLPSQEFQIPTFTIPNLYPLR
LPLLGVLDLSTSIYSNLYNWSASYTGGNTST-D--HWSLQAQYHVKADSVVNLLSYHVQG
SGKTAYDHRNTLTFSGDGSLHHKF-LDSNVKFSLVEKRGNSPASEGL---LTFDASSAWG
PQISASVHLDSKKKEHLYVKEVKIDGQFRASAFYAKGAYDLSYQRDPATGQLTGESNLRF
NSSYVQGTNQITGRYDDGTVSITSTSDLQDGLVKNTASLKYENYELTLKSDTNGKYEDFA
TSNKVDLTFSKQHALLRSEYQADYKALRFFTLLSGSLNSHGLELNADILGTDKINSGAHK
ATLRIARDGMSTSATTSLKYNPLVLENELNAAVSLSGASLKLTSNGRFREHHAKFSLDGK
AAPTEVSLGSAYQAMILGVDSKNIFHFKINQEGLKLSNDIMGSYDEMKLDYTNNLNIVGF
SLDFSSKLDNIYSSDKFYKQNFNLQLEPYSLVTTLNSDLKFSALDMTNNGKLRLEPLKLN
VGGTIKGAYQNDEIKHIYTLSYADLS-ASYKADT---VAKVQGTEFSHRLNTNIAGLAST
VDIRTNYNSDSLHFSNAFHSAVAPFTMTIDTHTNGNGELVLWGQHTGQLYSKFLLKAEPL
AFTFSHDYRGSTSHRLMSKRSITTALDHKVSALLTLAEQTGDWKLRTQLNQNEYSQDFSA
YNTKDKAGVELSGRALADLTVLDFPIAVPLVLNEPINVIDTFEMRDSVGQPQEFTLVASV
KYDKNQNAHTIHLPFFKFLPKYFEKTRVVVIGALETVQKELKRTHIDKHMRKYVEALDRL
SQQVSDYLSTFNWERQVLSAKEKLTAFT------ENDLQIVLDNATINLNEKLSQLQTYV
IQFDQYFEDNYDLHDFKTTIAKIIDQIIEKLKILDEHYHIRVNLVKKIRDLYFFIENFDF
NKTESSTASWIQNMDTKYQIRIQIQEKLQQLKVQIQTVDIHHLAEMFKQQVEAVDVRVLL
DQLRTTIPFQRIKEIIEHVKYRVTSLSEGFKVTEEINAFRVMVHEFIKMYKIDQHIQALM
DKSVQLAQQYKLQETVQKLSSVLQQVKMAEIVEKLIGLTDNALKQLEALSFNQFLEEVNR
FLDMLVKKLRSFDYHQFVDETNNKIHEVTQRINDEIQALEFPQKAKAL-RLLVEDARIVV
STYLENLKATKITLVLDWLQEALSSTSVTYMKAKFQETLEDFRDRVYQMDVQQELQRYLF
LVGQVYNTLVTYISDWWALAAKNLTDFAEQYSIQDWAENLKTLVEQGFTVPEIQTTFGTI
PAFKIGLRALQEATYQTPDFIVPLTDLRIPSFQINFKTLKDVKIPSSFSTPEFTILNTLH
IPSFTIDFVEIKIKIVRTIDQMLNSELQWPVPEVYLGDLSGVDTILAGITVPDFHLPEIT
IPEFVIPNLNLTDFQVSDLHIPEFQLPHISHTIEVPAFGKLYSILKIQSPFFTLDANADI
QNATA-LANQAEMEASITAKGASRLEVLNFDFQAKAQLSDPTL--NPLVLKEFVRFSSKY
LKTEHESEVLWVGNAIEGKSNTVAGIHTEKNTLKLSSSVLVNISNQLTLDSNTKYFHKLN
IPQLDFSSQADLHSDLKTLLEAGHIAWASSGRASWKLACHEFSDEGTHESQSSFTVEESI
TSFRLSNKINSKHLRVNQKILYESRFLNFSKFEIQSQAECQHVGRSVLTAKGLALLQEGK
AEITGNHDAHLNGKVVGTLRNSLFFSAQPYEMTASTNNEGNLRVSFPLKLTGKIDFLNNY
ALFLSPSTQQASWQASGRFNQYKYHQNFSAGNNEKSIEAHIGINGEANLDFLNIPLKIPE
MT--LPYTKLTTPQ-IKEISLWKKTGLKDFLKTTKQSFDLSVRAQYKKNKDKHSIPVPLD
AFYALIHRNINSFSRLFETVRNQALDFFIKSYNEAKTTFDKYKVEKSLNQQPKIYKIPGY
TIPV---ANIEVSPFTVKMLTFEYMIPKEISTPSITVLGSSISVPSYTLVLP-FLELPAL
PVPKELSELSLPEFKVLSTINKILIPALGNITYDFSFKSSVITLNTNVGLYNQSDIVAHF
LTSSSSVMDTLQYKLEGTSSLTRKRGLKLATALSLS-NRFVEGNHDSTVSFTKKNVDASV
TTTARVQIPILKMSFKQELHGNTKSKPTVSSAIELKYNFNSPKLLSAATGAVAHKLTLES
L-----TSYFSIESSTKGGVEGSFGS-WGYSGSLASEANTYLNSKGTRSSVTLQGASKAD
GLWDLKVKENFAGEATLQRIYIIWEQNMKNHLELGGLILTSGEHTSKATLELSLWKISAL
VQVRAHQPNSLLKINFLGQEVSLNVNTENQKISWNSEVQVPSGSLQNNIQLSNDQEVARF
DMAVSLEGYLRFLKDTVLPVYDKSLWDLLKLNVTTSLNRKQYLRAATALIYTKNPNGYLV
SIPMQELDDKFI--IPGLKRNNQNSIHVTPTFQVPFTDLQIPSYTLDLSEIKIYKNLSTL
PLTFNVSTLSQVKFPRVDVLIQYSKPEASSVPFFEITVPASQLTVSQFTLPKSISVGSTV
LDLNTVASNIADSELPTITVPEQTLEIPSMKFSVPAGILVPSFGTLTARFEVASPLYNTT
WSAGLKNKGDHVETFLDSTCSSTIQFLEYDLNVVGTHKIEGGMLVYKTNASFAHRDFSAE
YEEDGKYQGLGYWNGKVDLNITSPTLTDVCLHYQEDEN-HFSSSVAFPAIGTVVIDVKNI
SDTVLGWNL---YYR-PQASPDKILNIFKIELR--VLELDDEVQIKANWEEGAAS-ELLS
SLKDSVPRATGALYDYVNKYHQEYMGLDLKDATLKLRRGLQDSADQVYQGAMRQIDEVD-
-MELQRMARGTTETYQQWKDKAQSVYQELL-AQEDRSGFQRLQK-VSDSLIGVTQGYSVT
VKHATDLFIDLLNVTRFQLPGRARNYTADELCTVVIQEIAKRLSQVHSNIHKGLHILFSY
LLYLMEESELYKELNNKFSFTSMCNQ---------LIDMALECMKTFL----FFSQEIQK
ALSYLQSTMM-TEMLSDLQRSL-QDIFQEIESELKRFKEKKLTDFINQTLQNINTISDIY
ISFVFRFLKENLNYNFVEFN----KLIQNKLQVASQELQQLLQYVQALHQEYFDPTTVGW
TVKYYEFEEKVINLIKNLVDVLKDFHSKYIVGATDFASQLSSQIEPLIQKSLQEYLSILA
NAEGRGKEKITELSTSAQEVIKSWAVAVKEIISDYHQ

PF12491 // ENSGT00590000083139_0_Domain_6 (4658, 4715)

QFTYKLQEFSDQLSDYCEKFISE
SKRLIDLSIQNYHMFLNYIMELLKELQS-ATINDMSPYIKVAPGEFTITF----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------

-----------------------------------------------MGPLQL-------
----------QLL--LLLLLSYDVLTDDGPENGN-PACSKDAAR

PF01347 // ENSGT00590000083139_0_Domain_0 (105, 673)

FKPFRKYVYNYEAEIA
SGVKGTADSRSGSKITCKIELEVPQMCSFTLKASQCTLREMFGVDAEGKTLLKKSKNSDD
FARAMAQYEL-KFSTQDEKKIQLYSEKDEPMNILNIKRGIISALIVPTETEDNVKTI---
SMDTIYGKCDSEVEIKDRKGNIASVISINRN----LKTCENFNPIREYVSPIALIKGLNS
PLANLLSSSQSC-QYTIDAKKRHVAEVDCREKHLFLPASHKNQYGMMAQVTQTLKLDETP
--KINNRNFDEDKLERRGLSLEGADTKSLR--HGDAVLKVLQELQKLSASQQNQQRASLF
YKFVTGLRGLHNDTLGSLVQKMMEASSLSLIIMQGLIQCGTPDCFGAILQIIRTGNIDPL
VADAVTYSLGLLPFPCTKRIREILNMAQYQKSRATFYALSHAVTNFYE-DKKTVTQEI-T
DVANFMESMIGSECSGNDELTYLTLRAIGNMGKAMEVANPNLKSALKTCIKSEVASPSVQ
KAAIQALRRMTITDEDRAVLLKAFQSADSPVDKRLAAYLMLMKGPSPSDLSKITRALVKD
KNEQVKSFVASH

ENSGT00590000083139_0_Linker_0_3 (673, 709)

IANILDSEEIGIEDLKGKLQEALKGSQ-IPAPKDFR

PF09172 // ENSGT00590000083139_0_Domain_3 (709, 1024)

KFSQNYQISKRV
SLPGSD-PVSAKVEGNLIFDPKTYIPKETMLKTTLQLYGLSPMDIFEIGMDGKSFEPTLE
ALFGEKGFFPDSASKALFWVDGKVPEHVSKVLFDYFGYSKDDKQDQDVMKAIMLNFQKLI
KEMGNKEIPEGRAYLRILGEELGYMKLNDLNLLGNVILKSIKTLQAIPEKIV-QAISKGT
EGDFFVHYIFMDNEFELPTGAGLQLQFALSGIATPGAKAGVKIQQK-NMQADLIIKPSMA
IEFITHVGVNIPAFARSGVEMISNIYHESGIEAQVALKTVQLQLFISEAMSPLKLLEYSN
TLH

ENSGT00590000083139_0_Linker_3_5 (1024, 1042)

LVSPT----KTEVIPPLI

PF06448 // ENSGT00590000083139_0_Domain_5 (1042, 1156)

ENRESWTSCKPFFIGLNYCTKV-AYSNASYTAAAPYFPL
TGETRIEIELQPTGEVEEYSANANYELQREENDLVDTLKFTTETKGTRQSEASLTFRYNR
DKKILTSDFQIPNFD

ENSGT00590000083139_0_Linker_5_6 (1156, 4659)

IDFGTNFRVNDESTLDMRAYTFILDISNKKIPEVTLTGRIRYDGK
KETVLGGVISIPRLQTELRTEALLHHPPNRFSLQMDSS--ATVYGNSISETVVFRYDNEK
IELEWNSGTSTALKKMSDSFPV----DFADYPKALQKHANELLDRKVANTDMTLRHIVSQ
LIVATRTWLQKTSKDVPYAQTLQDKLNGLQDLNI----LPVITIPEELFLKSDGRIKYIW
NKDSVTINIPLPFGGRSSHDIRLPKIVKTPQLVMESIGINVPSQEFQLPLFTVPESYHLR
VPLLGTLEVSTNVYSNYYNWSASYAVANTT-KN--VSSLTTSYLMKADSVFDLLSYSIQG
SGEAMYD-RNAFDCKYENSLHHRL-LDSNFKFIRTNKYEPTLAIKQT---ILLTATSTLG
PQLSFSTNMDFRQKNNLNVNEVQMQGELRVASAFAKAIYTLSSNNSKNSHELAGTSNLIF
DSSYLHCTNEITGKSTKDALSLTSVSNVQRGLITNTASLKYEKRQLTVMSETNGRYQNFV
GLNKFELTLAMQKAAVRSENQAIYKENRYYTLFAGSLNSQGLELNSDITVNGQRNRATHK
STLRINQDGLASSATTNLHLNPLMLEEEMNARIDASGGTLAVTAKGRYGKDNAQINIDGR
MALREIALGSVYQSTILGMDSKNVLNFRINKEGLKFSNNLIGSYEEMKLEHVNELNIPGL
SLTFSSKLDNAISSDKFHKHYFDLQLQPYSLIAKLNNDLKYGETDVTNKAQLRLEPLKLT
MTGNVRGTYRTDEVKHAYTITYADLA-ANFKTDT---TAKIQGTALSHNINLDVAGLASS
ITINTNYNAKSLHFTNVVRSAMAPFTITADVHTNGDGRLFAMGEHTGQLYSKFLFKAEPL
AFTFSHDYKGSTSHSLTTGKKYTTLLDNKIHMLFTPSEQSSAWKLKSQVNNNVYTQDLGA
YNDAEKTGVELSGQALADFTVMDSPIQIPLM-SEPINLIDVLGLRDAVDQPQEFSISGSV
KYDKNKDEHVINLPFLEYLPIYFEQIRGAILSTLQSIQKHFKSIKIDHYVRKYRATIEKF
PRQVNDYMDKLDFKNRVNSMKEKLVAFTNDYRITADDLQNALENAKINFQEALSQLQLYL
IQIEQHVRDNYKHYDIRTVIEKLIDQIVEKIKVLDQQYNISATMITTIQDLQYIIAQHDP
SE--SSVSVWIQNMEAEYKIIAQVRGKLEQLKNQIHNIDANHIAEKLKQQVQDVDIKGFL
EKIRNSLPMKKMNEIIERIKDILLNLMEDYEVSEKINAFQSKMHDMIMKYEIDKQAQFLM
DRMIQMSDQYKVKETVQKLTISLKKIDIRSFFDKIVTVIDDAVKQVQEFDYQKLVDEVNK
FLDLVIKQLKSFDYNQFVDETNNKIREITHKINDEIRTLELPQKAEAL-KEYMKDINAMV
SKFVEQLRDTKLATVIDWFRDLISSTVFADLKVKLNEYLEDLRDRIYEMDIPKECQRYLQ
KASQFYNSIVGYISEQWNIASEKIALLAEQYDVKNWAEKVNVFVETGFIVPAIRTGIINI
PAFEVSLRALREATFQTPDFVVPLTDLHIPSYQIHIKKLKDIQIPVRFTTAEFTILNMYK
VPSYTIDLNEIKLKIVKIIDQMMSSEFQLPIPDMNFAELKMKDMLFSDISFPAIYIPEPQ
IPEFLIPKLNLNEFQFPNIQIPEYHLPRIPHTVTVPTFGKLSGAFRIVSPFFTLSTLAGI
HNTTV-SVNSPEFVATISAQATSRVDFLAFTMNADARLSAPEM--QQLILKETMKVTHSL
VKVDHNSEVIFLGTSVQGKAETTTSLRTTKNLIEVHNNLLVKLQRKILMQSKTTYSHRLN
IPQADLSSQADLMNDMTTELEAGHVSFTSSGKGNWKWAAPDFSDEGTHDSRATFTIEGPI
IAFVAENRINDKYLKINQNVNYECGLLNYATLQLQSVIESQHVGHSNLSVHGTGQLATMK
VEIKGNHMAKLNGRVSGTIRNNVALLVQPFEISVSTNNDGNVKVSFPLKLTGKIEFLNNY
GLVLSSSVQEVNWQASGRFNQYKYSHRMSAGNTEDKIEAHVGMNGEANLDFLKTPLSIPE
LH--IPYVGIKTSQVMKEYSLWEQTGLKDLLKTTKQSFDLNLNAQYKKNKDMYALPIPLK
AVQEGINQYIIFFNKYFVKGRDNALDFLTSSYNQAKTEFDKYKVETSLNKLPRTFKIPGY
TIPV---VNIEVSPFTAELPAFGYVIPKEISTTSFTIPLIGFSVPSYTLVLP-SLEMPVL
HVPSDLRTLKLPKFTVH-PSTHILIPALGNITYDFSFKSSMITLNTNIGLFNQSDIIARF
SSSSSSVIDAVQFNLDGTTSLTRKRGLKLATALSLSNNKFVEGKHESTVSLTKRNIEASV
TTNAKINLPVFKMNFNQELKGNTKSKTTVSSAINLNYDFDTLKYGASAKGAVDHKLTLES
L-----TSSISVETSTKGSINGMLYTQNPFSGMLIHEANTYLNSKGARSSVKLEGNSKAD
GIWNVDVAEKLAVEASTQRVYAIWEHNGENYGQFTPLLRTKGTQNCRVTLELVPWSMSAA
LQIQATQPNSFLDIASVNQVVLLNINTENQKLGWKGEGQIQSLSLSHDMQLSNEKTKVQF
DISGSLEGHIDFLKNFVCPVYEKSLWDILKLDLTTSADRKQYLNTSASIVCTKSEDGYFF
PLYVNRLADGFTITIPEMHLKAPNPVLTTPEFQVPFTTLQVPSYTMDLRNIKIPHKLSIM
PFDINLPSLPRMGIPKVDIGAQYITLEEYKIPYFEVTVPQYQITLSQFTLPKSISLGNMH
VDLNQVANKIADFDLPTVTISEQKIEIPPLKMSLPAGIYFPAFSALTGSFRVASPLYNVT
WKTDLKNNKDSFTSSIDSTSSSTLQFLEYDLEAVSSYSKEGDMSLAKATCSFSHRDMSVD
YKIDLPIQGKRILAHTASLNITSPTFTDVQLSYWGDSH-RISSSVSSPSAGTLGYLVEMD
T-DILRGKI---YYQ-TQYTPEKETDILKSEI---SFKKPDLIQIKTNWNDAAAT-DMLN
GLKEKIPKMTKALYTSINKYHHEHTGMEISDATQKLKNIMQNEAEKAYRLTTRKIDEID-
-LHLRNTAFQATGKYQEMTVKAKQLYQEAA-DQAVQIDYQQIRAKIFDATMNLLREYQKR
IKHLIDSAIEFLKITKFRFPGLAEKHTGEELYVMATEETAKATDALISKIQEYFDALIAF
VNEIE----------FKVPASDRILK-------------GSEVLDQIKEMLKRLQNNARQ
IFATLQEADF-AEKLKQLKQLV-QQVFQKVEEIIRNLQSKNFEEIKDQAQQMYNDAINSD
YAEKMSFLAENIKTYLSQLK----DFSKQTCNEISEKLHQILLYVKALREEYFDPSLVGW
SVKYYEVEDKVLDWLKNLIDALMDWHAKYIGDTADLVSRLTDQIKEFVENHGQRYYDLVT
DADGKGRQKAIELSSAAQEKIRYWSETAKKNSAEYNKL

PF12491 // ENSGT00590000083139_0_Domain_6 (4659, 4715)

VKVKIQGAHNQLSQAYERLISA
TQKLIDLTIENYSTFLQYITELLHQLEK-MTTDTIRPYIAVRQGELRLDIPIPFDLLSIY
QMPQLSEEAFQKKLEITRML---IQKGI----------------------DQGSKTWIEL
QTFIDQQLAVDQLN---------------------IQQIMENIQKRIKT-----------
------------------------------------------------------------
------------------------------------------------------------
--------------------------

-----------------------------------------------MGPPRPALL----
ALLALPALLL-LLAGARAEEE----M---LENVS-PVCPKDATR

PF01347 // ENSGT00590000083139_0_Domain_0 (105, 673)

FKHLRKYTYNYEAESS
SGVPGTADSRSATRINCKVELEVPQLCSFILKTSQCTLKEVYGFNPDGKALLKKTKNSEE
FAAAMSRYEL-KLAITEGKQVFLYPEKDEPTYILNIKRGIISALLVPPETEEAKQVL---
FLDTVYGNCSTHFTIKTRKGNVATEISTERD----LGQCDRFKPIRTGISPLALIKGMTR
PLSTLISSSQSC-QYTLDAKRKHVAEAICKEQHLFLPFSYKNKYGMVAQVTQTLKLEDTP
--KINSRFFGEG-TKKMGLAFESTKSTSPPKE-AEAVLKTLQELKKLTISEQNIQRANLF
NKLVTELRGLSDEAVTSLLPQLIEVSS--PITLQALVQCGQPQCSTHILQWLKRVHANPL
LIDVVTYLVALIPEPSAQQLREIFNMARDQRSRATLYALSHAVNNYHK-TNPTGTQEL-L
DIANYLMEQIQDDCTGDEDYTYLILRVIGNMGQTVEQLTPELKSSILKCIQSTKPSLMIQ
KAAIQALRKMEPKDKDQEVLLQTFLDDASPGDKRLAAYLMLMRSPSQADINKIVQLLPWE
QNEQVKNFVASH

ENSGT00590000083139_0_Linker_0_3 (673, 709)

IANILNSEELDIQDLKKLVKEALKESQ-LPTVMDFR

PF09172 // ENSGT00590000083139_0_Domain_3 (709, 1018)

KFSRNYQLYKSV
SLPSLD-PASAKIEGNLIFDPNNYLPKESMLKTTLTAFGFASADLIEIGLEGKGFEPTLE
ALFGKQGFFPDSVNKALYWVNGQVPDGVSKVLVDHFGYTKDDKREQDMVNGMMLSIEKLI
KDLKSKEVPEARAYLRILGEELGFARLHDLQLLGKLLLMGARTLQGIPQMIG-EVIRKGS
KNDFFLHYIFMENAFELPTGAGLQLQVSSSGVIAPGAKAGVKLEVA-NMQAELVAKPSVS
VEFVTNMGIIIPDFARSGVQMNTNFFHESGLEAHVALKAGQLKFIIPSPKRPVKLLS

ENSGT00590000083139_0_Linker_3_5 (1018, 1044)

AGN
TLHLVSTT----KTEVIPPLIEN

PF06448 // ENSGT00590000083139_0_Domain_5 (1044, 1156)

RQSWSVCKQVFPGLNYCTSG-AYSNASSTDSASYYPL
TGDTRLELELRPTGEIEQYSVSATYELQREDRALVDTLKFVTQAEGAKQTEATMTFKYNR
QSMTLSSEVQIPDFD

ENSGT00590000083139_0_Linker_5_6 (1156, 4658)

VDLGTILRVNDESTEGKTSYRLTLDIQNKKITEVALMGHLSCDTK
EERKIKGVISIPRLQAEARSEILAHWSPAKLLLQMDSS--ATAYGSTVSKRVAWHYDEEK
IEFEWNTGTNVDTKKMTSNFPV----DLSDYPKSLHMYANRLLDHRVPQTDMTFRHVGSK
LIVAMSSWLQKASGSLPYTQTLQDHLNSLKEFNLQNMGLPDFHIPENLFLKSDGRVKYTL
NKNSLKIEIPLPFGGKSSRDLKMLETVRTPALHFKSVGFHLPSREFQVPTFTIPKLYQLQ
VPLLGVLDLSTNLYSNLYNWSASYSGGNTST-D--HFSLRARYHMKADSVVDLLSYNVQG
SGETTYDHKNTFTLSCDGSLRHKF-LDSNIKFSHVEKLGNNPVSKGL---LIFDASSSWG
PQMSASVHLDSKKKQHLFVKEVKIDGQFRVSSFYAKGTYGLSCQRDPNTGRLNGESNLRF
NSSYLQGTNQITGRYEDGTLSLTSTSDLQSGIIKNTASLKYENYELTLKSDTNGKYKNFA
TSNKMDMTFSKQNALLRSEYQADYESLRFFSLLSGSLNSHGLELNADILGTDKINSGAHK
ATLRIGQDGISTSATTNLKYSLLVLENELNAELGLSGASVKLTTNGRFREHNAKFSLDGK
AALTELSLGSAYQAMILGVDSKNIFNFKISQEGLKLSNDMMGSYAEMKFDHTNSLNIAGL
SLDFSSKLDNIYSSDKFYKQTVNLQLQPYSLVTTLNSDLKYNALDLTNNGKLRLEPLKLH
VAGNLKGAYQNNEIKHIYAISSAALS-ASYKADT---VAKVQGVEFSHRLNTDIAGLASA
IDMSTNYNSDSLHFSNVFRSVMAPFTMTIDAHTNGNGKLALWGEHTGQLYSKFLLKAEPL
AFTFSHDYKGSTSHHLVSRKSISAALEHKVSALLTPAEQTGTWKLKTQFNNNEYSQDLDA
YNTKDKIGVELTGRTLADLTLLDSPIKVPLLLSEPINIIDALEMRDAVEKPQEFTIVAFV
KYDKNQDVHSINLPFFETLQEYFERNRQTIIVVLENVQRDLKHINIDQFVRKYRAALGKL
PQQANDYLNSFNWERQVSRAKEKLTALTKKYRITENDIQIALDDAKINFNEKLSQLQTYM
IQFDQYIKDNYDLHDLKIAIANIIDEIIEKLKSLDEHYHIRVNLVKTIHDLHLFIENIDF
NKSGSSTASWIQNVDTKYQIRIQIQEKLQQLKRHIQNIDIQHLAGKLKQHVEAIDVRVLL
DQLGTTISFERINDVLEHVKHFVINLIGDFEVAEKINAFRAKVHELIERYEVDQQIQVLM
DKLVELAHQYKLKETIQKLSNVLQQVKIKDYFEKLVGFIDDAVKKLNELSFKTFIEDVNK
FLDMLIKKLKSFDYHQFVDETNDKIREVTQRLNGEIQALELPQKAEAL-KLFLEETKATV
AVYLESLQDTKITLIINWLQEALSSASLAHMKAKFRETLEDTRDRMYQMDIQQELQRYLS
LVGQVYSTLVTYISDWWTLAAKNLTDFAEQYSIQDWAKRVKALVEQGFTVPEIKTILGTM
PAFEVSLQALQKATFQTPDFIVPLTDLRIPSVQINFKDLKNIKIPSRFSTPEFTILNTFH
IPSFTIDFVEMKVKIIRTIDQMLNSELQWPVPDVYLRDLKVEDIPLARITLPDFHLPEIA
IPEFIIPTLNLNDFQVPDLHIPEFQLPHISHTIEVPTFGKLYSILKIQSPLFTLDANADI
GNGTT-SANEAGIAASITAKGESKLEVLNFDFQANAQLSNPEI--NPLALKESVKFSSKY
LRTEHGSEMLFFGNAIEGKSNTVASLHTEKNTLELSNGVIVKITNQLTLDSNTKYFHKLN
IPKLDFSSQADLRNEIKTLLKAGHVAWTSSGKGSWKWACPRFSDEGTHESQISFTIEGPL
TSFGLSNKINSKHLRVNQNLVYESGSLNFSKLEIQSRVDSQHVGHSVLTAKGTALFGEGK
AEFTGRHDAHLNGKVIGTLKNSLFFSAQPFEITASTNNEGNLKVRFPLRLTGKIDFLNNY
ALFLSPSAQQASWQVSARFNQYKYNQNFSAGNNENIMEAHVGINGEANLDFLNIPLTIPE
MR--LPYTIITTPP-LKDFSLWEKTGLKEFLKTTKQSFDLSVKAQYKKNKHRHSITNPLV
VLCEFISQSIKPFDRHFEKNRNNALDFVTKSYNETKIKFDKYKAEKSHDELPRTFQIPGY
TVPV---VNVEVSPFTIEMSAFGYVFPKAVSMPSFTILGSDIRVPSYTLILP-SLELPVL
HVPRNL-KLSLPDFKELCTISHIFIPAMGNITYDFSFKSSVITLNTNAELFNQSDIVAHL
LSSSSSVIDALQYKLEGTTRLARKRGLKLATALSLS-NKFVEGSHNSTVSLTTKNMEVSV
ATTAKAQIPILRMNFKQELNGNTKSKPTVSSSMEFKYDFNSSMLYSTAKGAVDHKLSLES
L-----TSYFSIESSTKGDVKGSVLS-REYSGTIASEANTYLNSKSTRSSVKLQGTSKID
DIWNLEVKENFAGEATLQRIYSLWEHSTKNHLQLEGLFFTNGEHTSKATLELSPWEMSAL
VQVHASQPSSFHDFPHLGQEVALNANTKNQKIRWKNEVRIHSGSFQSQVELSNDQEKAHL
DIAGSLEGHLRFLKNIILPVYEKSLWDFLKLDVTTSIGRRQHLRVSTAFVYTKNPNGYSF
SIPVKVLADKFI--IPGLKLNDLNSVLVMPTFHVPFTDLQVPSYKLDFREIQIYKKLRTS
SFALNLPTLPEVKFPEVDVVTKYSQPEDSLIPFFEITVPESQLTVSQFTLPKSVSDGIAA
LDLNAVANKIADFELPTIIVPEQTIEIPSIKFSVPAGIVIPSFEALTARFEVDSPMYNAT
WSASLKNKADYVETVLDSTCSSTVQFLEYELNVAGTHKIEDGMLASKTKGTFAHRDFSAE
YEEDGKYEGLQEWEGKAHLNIKSPAFTDLQLHYQKDKK-GISTSAASPAIGTVGMDTDED
D-DFSTWNF---YYS-PQSSPDKKLTIFKTELR--VRESDEETQIKVNWEEEAAS-GLLT
SLKDNVPKATGALYDYVNKYHWEHTGLTLREASSKLRRNLQNNAEWVYQGAIRQIDDIE-
-VRFQKTASGTTGTYQEWKDKAQNLYQELL-TQEGQASFQGLKDKVFDGLVRVTQEFHMK
VKHLIDSLIDFLNFPRFQFPGKPGIYTREELCTMFIREVGTVLSQVYLKVHNGSEILFSY
FQDLV----------ITLPFELRKHK---------LIDVISMYRELLK----DLSKEAQE
VFKDIQSLKT-TEVLRNLQDLL-QFIFQLIEDNIKQLKEMKFTYLINYIQDEINTIFNDY
IPYVFKLLKENLCLNLHKFN----EFIQNELQESSQELQQIHQYIMALREEYFDPSIVGW
TVKYYELEEKIVSLIKNLLVALKDFHSEYIVSASDFTSQLSSQVEQFLHRNIQEYLSILT
DPDGKGKEKIAELSATAQEIIKSQATATKKIISDYHQ

PF12491 // ENSGT00590000083139_0_Domain_6 (4658, 4716)

QFRYKLQDFSDQLSDYYEKFIAE
SKRLIDLSIQNYHTFLIYITELLKKLQS-TTV--MNPYMKLAPGELTIIL----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------

-----------------------------------------------MGPPRS-------
------ALWLLLGLLLLLLDAGAQAEDKAPENVS-PSCLKEATR

PF01347 // ENSGT00590000083139_0_Domain_0 (105, 673)

FKHLRKYIYSYEAESS
SGIPGTADSRSATKINCKVELEVPQLCSFILKTSQCTLKEVYGFNPEGKALLKKTKNSEE
FAAAMSKYEL-RLAIPEGKQVLLYPEENEPKHILNIKRGIVSALLVPPETEEATQVL---
FLDTVYGNCSTNVMVKTRKGSVATEMSTERN----LQQCSGFQPISTGASPLALVKGLVR
PLSTLISSSQSC-QYSLDSKRKHVSEAICKEQHLFLPFSYRNKYGMMTQVTQTLKLEDTP
--KINSRFFGEG-FQMVGLAFESTKSTSLPKQ-AEAVLKTLQELKKLSISEQNAQRANLF
NKLVTDLRSLSTEAITSLLPQLIEVSS--PITLQALVQCGQPQCYTHVLQWLKSEKAHPL
LIDVVTYLVALIPDPSVHRLREIFSIAKEQQSRATLYALSHVVNNYFE-TTHTLNQDL-Q
DIANYLQEQIHNQCAGDEDHTYLILRVIGNMGRTLENITPMIKSLVLRCIRSSKPSVLIQ
KAAIQALRKMELGDEAQQLLLQTFVHSASPVEKRLAAYLMLMKGPSQPVINKIIQLLPRE
ENEQVKNFVASH

ENSGT00590000083139_0_Linker_0_3 (673, 709)

IANILNSEELYIGDLKNLVKEALKDSQ-LPTIMDFR

PF09172 // ENSGT00590000083139_0_Domain_3 (709, 1017)

KFSRNYHFSKSI
SLPSLD-PVSAKIEGNLIFDPNNYLPKESMLKTTLTVFGFASADLFEIGLEGKGFEPTLE
ALFGKQGFFPDSVSKALYWVNGQVPDHVSKVLEDHFGYTKDEKHEQDMVNGIMPIVDKLI
KDLKSRDIPEARAYLRILGKELGFFKLQDLQLLGRLLLSGARTLQGIPQMIG-EAIREGS
KNDLFLHYIFMDNSFELPTGMGLQLQVSSSGVITPGTKAGVKLEMA-NMQADLVMKPSVS
VEFVTNMGIIVPDFARSGVQMNTNFFHESGLEARVALKAGALKFIIPAPKRSIKLF

ENSGT00590000083139_0_Linker_3_5 (1017, 1044)

SGSN
TLHLVSTT----KTEVIPPLIEN

PF06448 // ENSGT00590000083139_0_Domain_5 (1044, 1156)

RQHWSTCRPFISGLNYCTTG-AYSNASSTESASYYPL
TGDTRYELELKPTGEVEQYSASATYELQREDKALVDRLKFVIQAEGVKQTEAALMFKYNR
RSRTLSSEMQIPDFD

ENSGT00590000083139_0_Linker_5_6 (1156, 4658)

VNLGTILRVSDESSKDKKSYKLNLDIQNKKITEVAFTGHISHDTK
GEGKIKGVISIPRLQAEARSEILTHWLSTKLLLQMDSS--ATAYGSTISKRVAWRYDDEK
IEFEWNTGTNVDTKKVASNFPV----DLSEYLTSLHMHANSLLDHRIPQIDMTFSEMGSK
LMATTNTWLQEASNSLPYAQILQDHLSGLKELNLQKMGLPYFHIPDNLFLKSDGRLKYVL
NKNSIEVEIPLPFGGKSSKDLKMLETIRTPALSFKSVGFHLPSQEFQVPTFTIPKLYQLR
VPLLGVLDLSTNVYSNLYNWSASYTGGNTSR-D--HFSLQARYHIKADSAVNLLSYSVQG
SGETTYDHRNTLTLSCDGSLRHKF-LDSNIKFSHVEKIGNNPASKGV---LTFDASSTWG
PQMSASVHLDSKKKQHLYVKDVKIDGQLRASPFYAKGTYGLTCQRDPTTGQLSGESNLRF
NSSYLQGTNQITGNYEDGTLSLTSTSDLQGGILKNTASLKYENYELTLKSDTNGKYENFA
TSNKVDLTFSKQNTLLRSEYQADYKSLRFFSLLTGSLNSHGVELNADILGTDKINTGAHK
ATLRIARDGISTSATTNLKYSPLFLENELNAELGLSGTSMKLTANGRFREHSAKFTLDGK
AALTEVSLGSAYQANIMGMDSKNIFNFKVSGEGLKLSNDLMGSYGEMTLDHANSLSIAGL
SLEFSSKLDNIYSTDKFYKQNFNFQLQPFSLVTSLNNDLKYSALDLTSSGKLRLEPLKLN
VGGNLKGAYQNNEIKHIYTISYADLS-ASYKADT---LARIQGTEFSHRLNTGITGLAAS
IDVSTNYHSDSLRFSNAFHSAMAPFTVAIDAHMNGNGKLTLWGEHTGQLYSKFLLKAEPL
ALTFSHDYKGSTSHNLLSRKSISMALDHKLNVLLVPSEQSSTWKLKTQLNNNEYSQDFDA
YNTKDKIGVELSGRGLADLTVLDSPITVPFLLREPINVLDALQMKEAVEQPKEFTVVAFV
KYDKNQDVHSVNLPFFKTLPEYWERNRIIIITALETIQRELKRINIDQFVRKYRGGLGKL
PQQVNDYLNALNWESQVASAKEKLTAFAENYRITENDLQTALNNAKINFNEKLSQLQTYV
IQFDQYIQDNYDLHALRIAITKIIDQIIENLKILDEHYHIRVNLVRTIHNLYLFIENVNF
NKMASSTASWIENVDTQYQIKVQIQEKLQQIRTQIQNIDMEELAAKLKQQVEAIDVRVLV
NQVRTTVPFQKIQNIIEYVKYFVINLIKDFEVTEKINAFRAIVHDLIKKYEVDQQMQVLI
DKSIQLAHQYKLKDTVQKLSNVLQRVDIKDYYEKLLVFIDDIIRQLKAFSFEKIIEEINL
LLDMLVKKLRSFDYHQFVDETNNTIREVIQIINGAFQGLDLPQKAEAL-KLFVEDVKVML
SAFLEKLKDTKITLFVDWLKDALNSAYFIPIKAKFQETLEDIRDRIYQMDIQQELERYLS
LVGQVYSTVVTYISDWWILAAKNLTDFAEQYSIQDWAENVKALVEQGLTVPKIQTILGTM
PAFEVSLRALQQASFQTPDFIVPLTDLRIPSVQINFKELKDIKIPSRFSTPEFTILNTFH
IPSFTIDFLEIKVKIIRTIDQMLNSEFQWPVPEVYLRDLKVEDILPARVILPNFHLPEIV
IPQFVIPNINLTEFQVPDLHVPEFQLPPISHTAEIPAFGKLSSLLKIQSPIFSIDAKADI
RNVTT-SEHRAGIEASIDAKGESKFTVFNFDFQANAQLVRPKI--NPLFLKESMNFSSKY
LRMEHESEILCSINAIDGKSDTVVSLRTEKNILELNNGMTLKINRQVTLNSHTKYSHKLN
IPKLDFSSKADLSNDVKMLLGAGHAALSSSGAGSWKWACPNFSDEGTHESQISFTVEGPL
VSLGLANKINSKHLRVTQILAYESGFLNFSKFEIQSDVESQHVGHSILTAKGIALLGKGK
AEITGDHNAHLNGKVIGTLKNSLFISAQPFEITASTNNEGNLKVSFPLKLTGKIDFQNNY
ALLLSPAAQQTSWQASARFNQYKYNQNFSATNNENSIEAHVSINGDANLDFLNIPLTIPE
MN--LPYTTLTTPS-LKDFSIWEETGLKEFLKTTKQSFDLNVKIQYKKNKDKHSIAVPLG
VFYKFISENVNSLDIYFENVRDDALDFLTTSYNKAKNKLDKYKAEKSLNTLPRTFQNPGY
TIPV---VNIEVSPFSVEMSPLSHVIPKAINTPSFTVPGSDFYVPSYTLVLP-SLKLPEL
HIPRNLLKLSLPDFKELSAVNNIFIPAMGNITYDFSFKSSVITLNTNAGLYNQSDIVAHF
LSSSSLVIDALQYKLEGTSRLTRKRGLKLATALSLS-NKFVEGSHDSTVSFTKKNMEASA
TTTAKVHIPVLRMNFKQELNGNTKSKPAVSSSIELKYNFNSPKLFSTAKGAIDHKLSLES
L-----TSYFSIESSTKADMKGLVHS-REYSGAIASEVSTYLNSKVTRSSVKLQGSSKVD
GIWNVEVKENFAGEATLLRIYAMWEHSMKNHLQPCRQFSTHGEHTSKATLELSPRTISAL
IQVRAHELNSVLGIPHFGQEVALNANTKNQKFSWKSDVQVHFGALQNSLQLSNDQKEARF
DIAGSLEGHLHFLKFIILPVYDKSLWDLLKLDVTTNSQKRQYLHASTALVYTKNPKGYPL
SVPVQELTDKFI--IPGLKLNDLNSELIIPAFQVPFTDLQIPSYKLDFNEIKIYKKLSTS
SFALNLPALPQVKFPQVDVLTKYSEPEDSSVPFFEITMPEVQLTVSQFTLPKNLSVGSAV
LDLSEVANMIGDFELPTITVPEQTIEIPSIKFSVPAGVFIPLFGALTARFGVSSPLYNAT
WNVGLRNNADHVETFLDSTCSSTLQFLEYDLNVVGTHKIEDGMLSCKTKGTFAHPDLSAE
YKEEGKYKSLEDWEGEMSLDIISPAFTELHLRYEEDEN-SMSSSAASPAIGTVGLDLGKE
GDHSFKWNF---YFQ-PQSSPDKKLNIFKTEWR--YQASDDKIQMKFNWEEEAVS-RLLG
SLKDNVPKATGAFYDYADKYHQEYTGLTLKDASSKLKRSLQESAEGAYQKAMRQLDEVE-
-VQFHRAASGTTGTYEEWKEKAEDLYRELL-AEEGQDNSQRLKAKIFDSLTQVTQESQMA
VKHLFDSFIDFLQLTRIQFPGIAGTYTRDELCTMVIREIGKVLSQVYSNIHNGLEKLLSF
VQDLVGKSELIKDLQIKFPFDSEPYK---------PAELILNYRKLLE----SYSQEVQE
AFIDLQSTKF-SEKLRYLQSLL-QRVFQEIEAEIKSLKETRFIHLINT----INTIFNTY
IPFAFGVLKESLCLHLTKLN----EFVQINLQLAFQGLQQIHQYIQALRQEHFDPHVIGW
TVKYYQLEEKIVDLIMNLVISLKDLHSIYTVRATNFASQLSTQFEQFARKEVQEYLSIFV
DAEGKGREKIAELSNTAQKVIKTLITAIKEIISDYQE

PF12491 // ENSGT00590000083139_0_Domain_6 (4658, 4713)

QFTSKLQEFSDQFSDYHEKFIAE
SQRLIDLSIQNYHMFLRYITEFLKKLQA-VTASGGSPYVKLAPGELTITY----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------

MLTSDFSPRCKCG-CGAACGRPSPGASEQRRGQAQTAGGRETPPRLAMGAPRP-------
------AVLL-LLLLLFLDAASTQARDEVLENVS-PSCPKDATR

PF01347 // ENSGT00590000083139_0_Domain_0 (105, 673)

FKHLRKYVYNYEAESS
SGVPGTADSRSSTKINCKVELEVPQLCNFILKTSHCTLKEVYGLDPEGKALLKKTKNSEE
FAAAMSKYDL-KLAVPEGKQVLLYPEKEEPKHILNIKRGIISALLLPPETEEAKQVL---
FLDTVYGNCSTDFTVKTKKGNVATEISIERN----LGKCDHFQPISTGVSPLALIRGMTR
PLSTMIGSSQSC-RYTLDPRRKHVSEAICNEQHLFLPFSYKNKYGMMAQVTQTLKLEDTP
--KINSRFFEEG-TEAVGLAFESTRSTSPPKH-AEAIVKTLQELQKLHVSEQNAQRANLF
HKLVTELRGLSSEAVTSLLPKLIEVSS--PITLQALIQCGQPQCYTHILQWLKNERANPL
LIDAVTYLVALIPEPSAERLREVFNTARVQQSRLTFYALSHVINNYHK-TNPTWTQDL-L
EIADYLSEQIGNDCTGNEDLTYLILRVIGNIGKTMEQLTPKLTSSVLKCIRSEQPSLVIQ
KAAIQALRKMELSDEVREVLLQTFLDDTSPGDKRLAAYLMLMGSPSQSDISKITQLLPRE
QNEQVKNFVASH

ENSGT00590000083139_0_Linker_0_3 (673, 709)

IANILNSEDLYVQDLKSLVEEALKKSQ-LPTIMDFK

PF09172 // ENSGT00590000083139_0_Domain_3 (709, 1017)

KFSQSYQFSKSI
SLPSLD-LVSAKIEGNLIFDPNNYLPKESMLKTTLKVFGFASADLFEIGLEGKGFEPTLE
ALFGKEGFFPDSVNKALYWVNGRVPDRVSKVLVDHFGYTKDDKHEQDMVNGIMFNVEKLV
KDLKSKDFPEARAYLRILGEELGFVRLHDLQLLGKLLLKGVHTLQGIPQMIK-ELVRKGS
TSDLFLHYIFMDNAFELPTGLGLQLQVSSSGIITPGIKAGVKLEVA-NMQAELVTKPSVS
VEFVTNMGIVIPDFARSGVQMNTNFFHETGLEARVVLKAGQLKFIIPSPKRPVRLF

ENSGT00590000083139_0_Linker_3_5 (1017, 1044)

SGSN
TLHLISTT----KTEAIPPLIEN

PF06448 // ENSGT00590000083139_0_Domain_5 (1044, 1156)

RQSWSTCKPFFIGLNYCITG-AYSNASSTDSSSYYPL
TGDTRFELELKPTGEVEQYSAKAFYELRRDGEALVDMLKLVTQTEGVKQTEATLLFRYNR
QSKTLSSELHIPDFD

ENSGT00590000083139_0_Linker_5_6 (1156, 4658)

VDLGTVLKVSYDPSKEKKSYKLTLDFQNKKITEVTLTGHISYDRR
EEGKIKGVISIPRLQAEARSEILSLWSPSKLLLQMDSS--ATAYGSTISKKVAWRYDGEK
IEFEWNTGTNVDTKKATSSFPV----DLSGLPKSLHTYANILLDRRVPQTDLTFRRMGSK
LVAAASTWLQETSRSLPYAQNIQDQLSGLQELCLQKMKLPNFHIPENLFLKSDGRIKYTL
NKNSMEIEIPLPFGGKSSEDLKMFKMIQTPALNFQPLGFHLPSQEFQIPTFTIPHLYPLR
LPLLGVLDLSTSIYSNLYNWSASYTGGNTST-D--HWSLQAQYHVKADSVVDLLSYHMQG
SGKTAYDHRSTLTLSGDGSLHHKF-LDSNVKFNHVEKRGNSPASKGL---LTFDASSAWG
PQISASVHLDSKKKEHLYVKEVKIDGQFRASAFYAKGAYDLSYQRDPATGQLTGESNLRF
NSSYVQGTNQITGRYDDGAVSITSTSDLQDGLVKNTASLKYENYELTLKSDTNGKYEDFA
TSNKVDLTFSKQNALLRSEYQADYKSLRFFTLLSGSLNSHGLELNADIMGTDKINSGAHK
ATLRIARDGMSTSATTSLKYSPLVLENELNAAVSLSGASLKLTSNGRFREHHAKFSLDGK
AAPTEVSLGSAYQAMILGVDSKNIFYFKINQEGLKLSNDIMGSYDEMKLDYTNNLNVVGF
SLDFSSKLDNIYSSDKFYKQNFNLQLEPYSLVTTLNSDLKFNALDMTNSGKLRLEPLKLN
VGGTIKGAYQNDEIKHIYTLSYADLS-ASYKADT---VAKVQGTEFSHRLSTNIAGLAST
VDISTSYNSDSLHFSNAFRSAVAPFTMTIDTHTNGNGKLVLWGQHMGQLYSKFLLKAEPL
AFTFSHDYRGSTSHHLTSRRSVTTALDHKVSALLTLAEQTGNWKLRTRLNQNEYSQDFSA
YNTKDKVGVELSGRALADLTVLDFPIAVPLVLSESINVIDTLEMRDSVGQPQEFTLVASV
KYDKNQNAHTIHLPFFKFLPKYFEKTRVVVIGALEAVQKELKRTHIDQHMRKCIAALNRL
SQQVSDYLSTFNWERQVLSAKEKLTAFTENYRMTENDLQIVLDNAKINLNEKLSQLQTYV
IQFDQYIEDNYDLHDFKTTVAKIIDQIIEKLKILDEHYHIRVNLVKKIRDLYFFIENFDF
NKVGSSTASWIQNMDTKYQIRIQIQEKLQQLKVQIQTVDIHHLAEMFKQQVEAVDIRVLL
DQLRTTIPFQRIKEIIEHVKYRVTSLSEGFEVTEEIKAFRVMVHEFIEMYKIDQHIQVLM
DKSVQLAQQYKLQETVQKLSSVLQQVKMAEIVEKLIGLTDNALKQLEALSFNQFLEEVNK
FLDMLVKKLRSFQYHQFVDETNNKIHEVTQRINDEIQALELPQKAKAL-RLLVEDARIVV
STYLENLKTTKITLFLDWLQEALSSTSVTYMKAKFQETLEDFRDRVYQMDVRQELQRYLF
LVGQVYNTLVTYISDWWALAAKNLTDFAEQYSIQDWAENLKTLVEKGFTVPEIQTTFGTI
PAFEISLRALQEATYQTPDFTIPLTDLRIPSFQINFKTLKDVKIPSSFSTPEFTILNTLH
VPSFTIDFVEIKIKIIRTIDQMLNSELQWPVPEVYLGNLSGVDTILAGITVPDFHLPEIT
IPEFVIPNLNLTDFQVSDLHIPDFQLPHISHTIEIPAFGKLYGILKIQSPFFTLDANTDV
QNATA-SENQAEIEASISAKGASRLEMLNFDFQAKAQLSDPTI--NPLVLKESLRFSSKY
LKTEHESEMLWVGNAIEGKSNTMAGIHTEKNTLELSNGVLVKINNQLTLDSNTKYFHKLN
IPQLDFSSQADLHSDLKTLLEAGHIAWASSGTASWKLACHDFSDEGTHESQSSFTVEESI
TSFRLSNKINGKHLRVNQKILYESRFLNFSKFEIQSQAECQHVGRSVLTAKGLALLQEGK
AEITGNHDAHLNGKVVGTLKNSLFFSAQPYEMTASTNNEGNLRVSFPLKLTGKIDFLNNY
ALFLSPSTQEASWQASGRFNQYKYHQNFSAGNNEKSIEAHIGINGEANLDFLNIPLTIPE
MT--LPYTKLTTPQ-MKEISLWEKTGLKDFLKTTKQSFDLSVRAQYKKNKDKHSIPVPLN
AFYTLIHRNINSFSRLFERVRNQALDFFTKSYNEAKTTFDKYKVEKSLNQQPKIYKIPGY
TIPV---ANIEVSPFTVKMLTFEYMIPKEISTPSITVLGSGIYVPSYTLVLP-FLELPTL
HVPKELSELSLPEFKVLSTINKILIPALGNITYDFSFKSSIITLNTNIGLYNQSDIVAHF
LTSSSSVMDALQYKLEGTSSLTRKRGLKLAAALSLS-NRFVEGNHDSTISFTKKNMDASV
TTTARVQIPILKMTFKQELHGNTKSKPAVSSVIELKYNFNSPKLLSAAMGAVTHKLTLES
L-----TSYFSIESSTKGSVEGSFGS-QGYSGSLASEASTYLNSKGTRSSVTLQGASKAD
GLWDLKVKENFAGETTLQRIYTIWEQNIKNHLELGGLILTSGEHTSKATLELSLWKISAL
VQVRAHQPGSLLKINYLGQEVSLNVNTENQKISWKSQVQVHSGSLQNNIQLSNDQEVARF
DMAVSLEGHLRFLKDTVLPVYDKSLWDLLKLDVTTSLNRKQYLRAATAVIYTKNPNGYLV
SIPMQELDDKFI--IPGLKRNNQNSVYVTPTFQVPFTDLQVPSYTLDLSEIEIYKKLSIL
PLTFNVSTLPKVKFPRVDVLIQYSKPEASSVPFFEITVPAAQLTVSHFTLPKSISVGSTV
LDLNAVASNIADFELPTITVPEQTLEIPSMKFSVPAGILVPSFGTLTARFEVASPLYNTT
WSAGLKNKGDHVETFLDSTCSSTIQFLEYDLNVVGTHKIEGGMLVYKTNASFAHRDFSAE
YEEDGKYQGLGYWNGKVDLNITSPTLTDVCLHYQESEN-HFSSSVASPAIGTVVIDVKNI
SNTLLGWNL---YYR-PQASPDKILNIFKMELR--VLELDDEVQIKANWEEGAVS-ELLS
SLKDSVPRATRALYDYVNKYHQEYTGLDLKDASLKLRRGLQDSADQVYQGAMRQIDELD-
-MELQRMARGTTETYQQWKDKAQSLYQELL-AQEDRSGFQRLQKKVSDSLIRVTQGYNVT
VKRATDLLVDLLNVTRFQLPGRARNYTADELCTVVTQETAKRLSQVHSNIHNGLHILFSY
LLYLTEESELYKDLNNKFSFTSMHNQ---------LISMVLEYVKMSI----FFSQEIQK
ALSYLQSTMM-TEMLSDLHRSL-QDTFQEIERELKRFKEKKLTDFINQTLQNINTIFDIY
ISFVFRFLKENLDYNFVEFN----ELIQNKLQVASQELQQLHQYVQALHQEYFDPTTVGW
TVKYYEFEEKIVNLIKNLVDVLKDFHSKYAVGAADFASQLSSQIETLIQKYLQEYLRILA
NAEERGKEKITELSTSAQEVIKSWTIAVKEIISDYHQ

PF12491 // ENSGT00590000083139_0_Domain_6 (4658, 4715)

QFTYKLQEFSDQLSDYCEKFISE
SKRLIDLSIQNYHMFLNYIMELLKELQS-ATVNDMSPYIKVAPGEFTITF----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------

-----------------------------------------------MGPPRPALL----
AL---PALLL-LLAGARAEEE----M---LENVS-PVCPRDATR

PF01347 // ENSGT00590000083139_0_Domain_0 (105, 673)

FKHLRKYTYNYEAESS
SGVPGTADSRSATRINCKVELEVPQLCSFILKTSQCTLKEVYGFNPEGKALLKKTKNSEE
FAAAMSRYEL-KLAIPEGKQVFLYPEKDEPTYILNIKRGIISALLVPPETEEAKQVL---
FLDTVYGNCSTHFTVKTRKGNVATEISTERD----LGQCDRFKPIRTGISPLALIKGMTR
PLSTLISSSQSC-QYTLDAKRKHVAEAICKEQHLFLPFSYKNKYGMVAQVTQTFKLEDTP
--KINSRFFGEG-TKKMGLAFESTKSTSPPKQ-AEAVLKTLQELKKLTISEQNIQRANLF
SKLVTELRGLSDEAVTSLLPQLIEVSS--PITLQALVQCGQPQCSTHILRWLKRVHANPL
LIDVVTYLVALIPEPSAQQLREIFNMARDQRSRATLYALSHAVNNYRK-TNPTGTQEL-L
DIANYLMEQIQDECTGDEDYTYLILRVIGNMGQTMEQLTPELKSSILKCVQSTKPSLMIQ
KAAIQALRKMEPKDKDQEVLLQTVLDDASPGDKRLAAYLMLMRSPSQADINKIVQLLPRE
QNEQVKNFVASH

ENSGT00590000083139_0_Linker_0_3 (673, 709)

IANILNSEELDIQDLKKLVKEALKESQ-LPTVMDFR

PF09172 // ENSGT00590000083139_0_Domain_3 (709, 1023)

KFSRNYQLYKSV
SLPSLD-PVSAKIEGNLIFDPNNYLPKESMLKTTLTAFGFASADLIEIGLEGKGFEPTLE
ALFGKQGFFPDSVNKALYWVNGQVPDGVSKVLVDHFGYTKDDKHEQDMVNGMMLSVEKLI
KDLKSKEVPEARAYLRILGEELGFARLHDLQLLGQLLLMGARTLQGIPQVIG-EVIRKGS
KNDFFLHYIFMENAFELPTGAGLQLQISSSGVIAPGTKAGVKLEVA-NMQAELVAKPSVS
VEFVTNMGIIIPDFARSGVQMNTNFFHESGLEAHVALKAGQLKFIIPSPKRPVKLLSGGN
TL

ENSGT00590000083139_0_Linker_3_5 (1023, 1042)

HLVSTT----KTEVIPPLI

PF06448 // ENSGT00590000083139_0_Domain_5 (1042, 1156)

ENRQSWSVCKQVFTGLNYCTSG-AYSNASSTDSASYYPL
TGDTRLELELRPTGEIEQYSVSATYELQREDRALVDTLKFVTQAEGAKQTEATMTFKYNR
QSMTLSSEVQIPDFD

ENSGT00590000083139_0_Linker_5_6 (1156, 4658)

VDLGTILRVNDESTEGKTSYRLTLDIQNKKITEVALMGHLSCDTK
EERKIKGVISIPRLQAEARSEILAHWLPAKLLLQMDSS--ATAYGSTVSKRVAWRYDEEK
IEFEWNTGTNVDTKKMTSNFPV----DLYDYPKSLHMYANRLLDHRVPQTDMTFRHMGSK
LIVAMNSWLQKASGSLPYTQTLQDHLNSLKEFNLQNMGLPDFHIPENLFLKSDGRVKYTL
NKNSLKIEIPLPFGGKSSRDLKMLETVRTPALHFKSVGFHLPSREFQVPTFTIPKLYQLQ
VPLLGVLDLSTNVYSNLYNWSASYSGGNTST-D--HFSLQARYHMKADSVVDLLSYNVQG
SGETTYDHKNTFTLSCDGSLRHKF-LDSNIKFSHVEKLGNNPVSKGL---LTFDASSSWG
PQMSASVHLDSKKKQHLFVKEVKIDGQFRVSSFYAKGTYGLSCQRDPNTGRLNGESNLRF
NSSYLQGTNQITGRYEDGTLSLTSTSDLQSGIIKNTASLKYENYELTLKSDTNGKYKNFA
TSNKMDMTFSKQNALLRSEYQADYESLRFFSLLSGSLNSHGLELNADILGTDKINSGAHK
ATLRIGQDGISTSATTNLKYSLLVLENELNAELGLSGASMKLTTNGRFREHNAKFSLDGK
AALTELSLGSAYQAMILGVDSKNIFNFKISQEGLKLSNDMMGSYAEMKFDHTNSLNIAGL
SLDFSSKLDNIYSSDKFYKQTVNLQLQPYSLVTTLNSDLKYNALDLTNNGKLRLEPLKLH
VAGNLKGAYQNNEIKHIYAISSAALS-ASYKADT---VAKVQGVEFSHRLNTDIAGLASA
IDMSTNYNSDSLHFSNVFRSVMAPFTMTIDAHTNGNGKLTLWGEHTGQLYSKFLLKAEPL
AFTFSHDYKGSTSHHLVSRKSISAALEHKVSALLTPAEQTGTWKLKTQFNNNEYSQDLDA
YNTKDKIGVELSGRTLADLTLLDSPIKVPLLLSEPINIIDALEMRDAVEKPQEFTIVAFV
KYDKNQDVHAINLPFFETLQEYFERNQQTIIVVLENIQRDLKHINIDQFVRKYRAALGKL
PQQANDYLNSFNWERQVSRAKEKLTALTKKYRITENDIQIALDDAKINFNEKLSQLQTYM
IQFDQYIKDNYDLHDLKIAIANIIDEIIEKLKSLDEHYHIRVNLVKTVHDLHLFIENIDF
NKSGSSTASWIQNVDTKYQIRIQIQEKLQQLKRHIQNIDIQHLAGKLKQHVEAIDVRVLL
DQLGTTISFERINDILEHVKHFVINLIGDFEVAEKISAFRAKVHELIERYEVDQQIQVLM
DKLVELAHQYKLKETIQKLSNVLQQVKIKDYFEKLVGFIDDAVKQLNELSFKTFIEDVNK
FLDMLIKKLKSFDYHQFVDETNNKIREVTQRLNGEIQALELPQKAEAL-KLFLEETKATV
AVYLESLQDTKITLIIDWLQEALSSASLAHMKAKFRETLEDTRDRMYQMDIQQELQRYLS
LVGQVYSTLVTYISDWWTLAAKNLTDFAEQYSIQDWAKRVKALVEQGFTVPEIKTILGTM
PAFEVSLQALQKATFQTPDFIVPLTDLRIPSVQINFKELKNIKIPSRFSTPEFTIFNTFH
IPSFTIDFVEIKVKIIRTIDQMLNSELQWPVPDVYLRDLKVEDFPLMRITLPDFHLPEIA
IPEFIIPNLNLNDFQVPDLHIPEFQLPHISHTIEVPTFGKLYSILKIQSPLFTLDANADI
GNGTT-SANEAGIAASITAKGESKLEVLNFDFQANAQLSNPKI--NPLALKESVKFSSKY
LRTEHGSEMLFFGNAIEGKSNTVASLHTEKNTLELSNGVIVKINNRLTLDSNTKYFHKLN
IPKLDFSSQADLRNEIKTLLEAGHITWTSSGKGSWKWACPRFSDEGTHESQISFTIEGPL
TSFGLSNKINSKHLRVNQNLVYESGSLNFSKLEIQSQVDSQHVGRSVLTAKGTALFGEGK
AEFTGRHDAHLNGKVIGSLKNSLFFSAQPFEITASTNNEGNLKVSFPLKLTGKIDFLNNY
ALFLSPSAQQASWQVSARFNQYKYNQNFSAGNNENIMEAHVGINGEANLDFLNIPLTIPE
MR--LPYTIITTPP-LKDFSLWEKTGLKEFLKTTKQSFDLSVKAQYKKNKHRHSITNPLA
VLYEFISQSIKSFDRHFEKARNNALDYVTKSYNETKIKFDKYKAEKSHDELPKTFQIPGY
TVPV---VNVEVSPFTIEMSAFGYVFPKAVSMPSFTILGSDIRVPSYTLMLP-SLELPVL
HVPRNL-KVSLPDFKELCTISHIFIPAMGNITYDFSFKSSVITLNTNAELFNQSDIVAHL
LSSSSSVIDTLQYKLEGTTRLTRKRGLKLATALSLS-NKFVEGSHNSTVSLTKKNMEASV
ATTAKAQIPILRMNFKQELNGNTKSKPTVSSSMEFKYDFNSSMLYSTAKGAVDHKLSLES
L-----TSYFSIESSTKGDVKGSVLS-REYSGTIASEANTYLNSKSTRSSVKLQGTSKID
DTWNLEVKENFAGEATLQRIYSLWEHSMKNHLQLEGLFFTNGEHTSKATLELSPWEMSAL
VQVHASQPSSFLDFPHLGQEVALNANTKNQKIRWKNEVRIHSGSFQSHVELSNDQEKAHL
DIVGSLEGHLRFLKNIILPVYDKSLWDFLKLDVTTSIGRRQHLRVSTAFVYTKNPNGYSF
SIPVKVLADKFI--IPGLKLNDLNSVLVMPTFHVPFTDLQVPSYKLDFREIKIYKKLRTS
SFALNLPTLPEVKFPEVDVLTKYSQPEDSLIPFFEITVPESQLTVSQFTLPKSVSVGIAA
LDLNAVANKITDFELPTIIVPEKTIEIPSIKFSVPAGIVIPSFQALTAHFEVDSPLYNAT
WSASLKNKADHVETVLDSTCSSTVQFLKYELNVVGTHKIEDGMLASKTKGTFAHRDFSTE
YEEDGKYEGLQGWEGKVHLNIKSPAFTDLHLRYQKDKK-GISTSAASPAIGTVGMDMDED
D-DFSKWNF---YYS-PQSSPDKKLTIFKTELR--VRESDEETQIKVNWEEEAAS-GLLT
SLKDNVPKATRAFYDYVNKYHWEHTGLTLTEASSKLRRNLQNNAEWVYQGAIRQIDDID-
-MRFQKAASGTTGTYQEWKDKAQNLYQELL-TQEGQASFQGLKDKVFDGLVRVTQEFHMK
VKHLIDSLIDFLNFPRFQFPGKPGTYTREELCTMFIREVGTVLSQVYSKVHNGSEILFSY
FQDLV----------ITLPFELRRHK---------LIDVISMYRELLK----DLSKEAQE
VFKAIQSLNS-TEVLRNLQDLL-QFIFQLIEDNIKQLKEMKFTYLINYIQDEINTIFKDY
IPYVFKLLKENLCLNLRKFN----EFIQNELQEASQELQQIHQYIMALREEYFDPSIVGW
TVKYYELEEKIVSLIKNLLVALKDFHSEYIVSASDFTSQLSSQVEEFLHRNIQEYLSILT
DPDGKGKEKIAELSTTAQEIIKSQAIATKEIISDCHQ

PF12491 // ENSGT00590000083139_0_Domain_6 (4658, 4717)

QFRYKLQDFSDQLSDYYEKFIAE
SKRLIDLSIQNYHTFLIYITELLKKLQS-TAV--MNPYMKLAPGELTIIL----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------

-----------------------------------------------MGQQWPWPP----
------PP-PLLLLLLLLLDTSVWAQEEVLENVG-LSCSN-AAR

PF01347 // ENSGT00590000083139_0_Domain_0 (105, 385)

FKHLRKYAYDYEAESS
SGVHGTADSRSATKIHCKVELEVPQLCSFILRTSQCTLKEVYGFNPEGKALMKKTKNSEE
FAAAMSRYEL-KLAIPEGKQVVLYPEKDEPTHILNIKRGIISTLLVPLETEEAEQVS---
FLDTVYGNCSTRLTVQTRKGSVATQISMERD----LQECDGFQPISTTVSPLALIKGLVR
PLSTLISSSQSC-QYTLDSKRRHVSEASCQEQHLFLPFSYKNKYGMMTQVTQTLKLEDMP
--KINSRFFSEG-AKQVGLAFESTKSSSPPKQ-AEAVVKTLQ------------------
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----------------------------------------DATR

PF01347 // ENSGT00590000083139_0_Domain_0 (105, 673)

FKPLRKYVYSYEAETS
SGVTGTADSRSGSKITCKVELEIPQLCRFILRTMHCSLRETFGVDTEGKAILKKSKNSED
FASAMSKNEL-KFSIQDGTKVKLYPEKDEALNVLNLKRGIISALLVPTETVENIKTI---
PMDTVYGKCDSEVEFKSRKGNVAEDISITRY----LKDCDNFSPIRDHVSPIAIVKGLNT
PLSALLKSTQFC-HYNIDAKKRHIRDVVCSEKHLFLPSSYKNLYGVMTEVNQTLKLEDTP
--KITNKNFDGG-IAAKGLALESTDANLPR--QGDAVLKTLQEIQKLTASQENQQRARLF
YRFVSGLRSLHNSTLGSLVPKMMETSS--SVTVQALAQCGTPECYSAILQILRTGNVNPL
VADLVTYTLGLLPSPTPQRIREILNMAQYQPSRASFYGLSHSVTKFYN-EKKIVTEEI-A
DVADFMVSLLGTDCSGEDELTYLTLRAIGNMGAVMEKAKPSVKASLKTCIRNEAASLPVQ
KAAIQAFRKMTITEEDRSALLKAFQELDAPTDKRLASYLLVMKNPSPSDLAKILRVLTKE
KSEQVKSFVASH

ENSGT00590000083139_0_Linker_0_3 (673, 709)

IANILDSEELGIEDLKSRVEEALKGNQ-LPKAKDFI

PF09172 // ENSGT00590000083139_0_Domain_3 (709, 1025)

KFSQNYQISKRV
SVPGID-PISAKVEGNVIFDPNSYIPKETMLKTTLHAYGFDSSDVFELGLDGKGFEPTLE
ALFGENGFFPDTATKALYWVDGKVPEKVSKALFDYFGYSQDGKQDQDIMKGIILNLEKLI
KELGSKEAPEGRAYLRILGEELGYMKLNDFKLLGSLILKSAKTLQTVPEMIA-QAISKGV
DRDLFVHYIFMDNEFELPTGAGLQLKFALSGIATPGARVAAKLHQK-SMQADLIAKPSVA
VEFVTHLGINMPEFAGSGVEMNSNIFHESGIEAHVSVKAGQLKFSIPAPKSPVKLLSISN
TLHL

ENSGT00590000083139_0_Linker_3_5 (1025, 1043)

VSPT----KTEEIPTRIE

PF06448 // ENSGT00590000083139_0_Domain_5 (1043, 1156)

NQETSTSCKPFIPGLNFCTKV-LYPNSTDAEAVPYFPL
TGESRFEVELVSTGKVKEYSASANYELQREGNDQIDTLKFAVQAEGVNKHGATLTFRYNK
GKKILTSDVQIPDVG

ENSGT00590000083139_0_Linker_5_6 (1156, 4658)

VDFGTNFRITDESISGKKAYTFVLDVNNKKITEVTLTGQIRYAGV
EEAMLRGTISFPRLETELRSEALVNYSPKKAYLQISSA--ATIYGNSISKRVLLRYDAEK
VELEWNSGASAAVKKLCSAFPV----DFSDYSKTLEKHTNELLDQKVAHTDMTLRHIVSQ
FIVATNTWLQKTSKDVPYAQTLQDKLSALQELSIQKLNLPVITIPEELFLKSEGRVRHNL
NKNSFVIDIPLPFAGKSSDEIWMPKTVKTPPLVVESMGISVPSQEYRIPSFTVPKSYPFR
VPLLGKLEVSANVYSNYYNWTAAYTVTNSTSER--ATSVKATYNTNADSVFELLSFSVQG
SGEASYN-RNGFICAYENHLKHRV-LTSVFKLSGRKSYEPIPLTNYT---LSLTASSTLG
PQLSFSSDIVSEKINNMNTNNVKIEGQLEVASVFARSIYTLSTTYNEKRRVLEGKSNLKL
DSSHLQATNQISGRYSDGSFSITSVSDVQNGLLKNTASLKCENSQLKMSSETNGKYQHTA
GVNKLEIVLSKKMAALRSEYQATYKQIQYFAVFAGSLNSQDLVFNTDISLTDQKYRAAHK
SSLNVNRYGLASSATTNVQFSPLAMQSEINAKLDTAGGSMSLSSSGRYGKNNAKFNVGGR
VSLTEITLGSEYQSTVLGMDNKHILNFRVNREGLKFSNNLQGSFKEIKLEYTNDLNIPGL
SLTFVSKLDNSFGFDKFHKHVFDLQLEPSSLTAKLSNNLKYTKTEVSNKAELLLEPLKMN
LGGNVRGAHEADEIRHTYTLTCAALT-ADLKTDT---VANIQGAAVSHRVHLDVAGLSSS
VTMNTNCDSKPLRFSNAVRSTMSPFVITADVHTNANGKLVAVGEHTGDLYSKLLFKAEPL
AFTFSHDYRGSTSHSLKSRGRYTTLLDNKVHMLFTPSEQSSAWKLKSQLNNNVYSQDFSA
YNNAEKIGVELNGRALADLSVMDTSVILPLT-YEEVNLIDVLGLRSSISEPQEFSISGFV
KYDKNKDMHVISLPFLENLPVYFEKLRGTILSTLQAIQSYLKNIDIEQHMKKYKATLNKL
PEDINDYMDKLDIKGKVSSMKNNFVAFTKDYRITSDDLQIMLEKALDNLQEILSQLQIYL
IKVEQYIKDSYEQYDINTLIAQLLDQIIETLTALDNKYQVRTTVINIIEKLQVFFQQYDL
NKIGSSTLAWIKNFDDEYGITAKIQENLELLKIHIQNIDVRSVAENLKRQIKEFDAKECL
EKFKRSLPIKKINEIIEQIKDFILNWIEEYELSEKISAFRGHMHKLIIKYEIDKQIYFLI
DRMIELLKTYRIKETVQKLTIYLQNVDVKSCFDKVVAFVDDAVKKVQTFDYEKMIKQVNK
FLDVIIKKLKAFDYDQFVDDTNNKIREVTQKINEELRNLELPQKAEAL-KQYIRDLRSVI
SKYMEQLKDTNLAAVINWLRELIDSTTFANLKAKVNEYLEDLRERISEMDISQELQWCLQ
KISQFYNSVVAYISHQWNTASKKITALAEEYDLKNWAENVKQFVETGFKVPEIRAVIVTI
PAFEVSLRSLREATFRTPEFIVPLTDLRIPSYEINIKRLKDVKIPMKFTTPEFKILNTFQ
IPSFTIDLIEVKLLIVRTIDKFMSAEFQFPSIDVYLKDLKMRDMAFSDISFPEIHMPQFQ
IPELLIPKLNLNQLRIPNVKIPEFQLPRIPHTVTVPTFGKLSGAFRVTSPFFTLSTQAEL
RNTTT-SANSPEFVTSISAQTTSKLDFLVFSVIADSRFLAPDM--KQLNLKNAMKVSHRF
LKVDHTNEVVFLGTSVEGEAETRANLNTKKNSVELQNNFMVKLQRRIWMQSGMVYSHRLN
IPQADFSSQADLINNMTTEVEAGYISFTSAGKGNWKWTSPNFSDEGTHDSHATFKIEGPS
ITFSANNRINAKYLKVNQAMKYECHSLMSALLQIQSEIESQRVGRSLLNVQGTGELLEMK
VELTGSHNARLHGRITGTVNNELSFIANLSEIHLAANNDGNVKISFPMKLTGKIDFLNNY
GFTLSPSVHQVNWQATGRFNQYRYFHNISAGSNDDRIEAHIEMNGDANLDFLNIPLSIPQ
IQ--IPYTGIRTPQ-LKDYSLWEQVGLKELLKTTRQSFDLNFNAQYEKNKDMHAIPLPLA
KVYEVLNKNILLFNKHFEKGRNTALDFLTKSYNEAKTKLDKYKIQTSLNKIPRTLTIPGY
TIPV---VNIEVSPFTAEMPAFGFTLPKEISTRGFTVPIIGFSVPSYTLVVP-SFELPVL
HIPQDLRTLKLPRFRINSSANNILVPAMGNITYDFSFKSSVITLTANAGLFNQTDIVGHL
SVSSSSVIEALQFKLDGSTSLTRKRGLKLATALSLSNNKYLGGNHDSTITLLKRIMEASV
ATNIEFDTPVLKLNFSQELSGNTKSKPTLSSGIKLIYDFNTPKYGTSAKGEIAHKFALET
L-----TYYISVESSTTGDIDGVFYTGNAFSGSVDHEANAYLNANGARSSLRFEAHSKAD
GLWVIEIKELLAVEASARRIYAVWEHNGKNYARCTSSFTTTGTQKCKATLELAPWDVSAD
LQIQAIQPNPYMGMVSVNEAVVVKISPANQKAGWKGEGQIHSLSLSHDMQLSNENSEAKF
VISGSLEGYMDFLKVIKCPISEKSLWDILKLDVTTSADRKQYINGSAALVYTKSEDGYFF
PIPVNKLTDGFTVTVPGLHLKAPSPVLSTPEFSLPFTTLQVPAYTVDLRNIKIPQTLSSM
PFDVHLPTLPKLRFPRVDVGANYITLEEYKMPFFEVTIPEYQITMSQFTLPKNVSFGSFS
VDLDEVTNKIADFEMPTITIPEQKIEIPPLKISLPAGIYIPSFGALTGSFKVVSPLYNVT
WRTDLTNKKDSFEHSIDSTCSSTLQFLEYDLNVVSNYEYKEGVFVMKITGSFSHRDLSAN
YQENLTISGVRDTEDSLSLDIISPTFTDVHVRYQENERKS-FGSISSPSAGTLAYLVEVA
D-ETLLARV---YYQ-TQSAPQNDIDILKGEI---SLKEPDQIQMKFNWNEDASK-DLLL
GLKERVPQMTNAIYRYVNRYHKEHMGLEISAATLKMKNIMQNNAEKAYTFAANQIDEID-
-AQLRTAANEASDKYQELKFKAKRLYRRAA-DQAEQFDYQRIKAELLNVLIDIIEEYHQK
IKHVIDSATEFLKTTKFQVPGLSEKYSGAEIYLMTTEKVAKTADVCLSKLQEYFDALIAA
INELE----------VRLPASETILR-------------GRNVLDQIKGMLKDLQNKIRQ
VFATLQEADF-AGRLKQLKQAV-QQVFQKVEEMVRSLQSKTFEDIKVETQQLYKDAMASD
FAQKLRSLTKDVKKYISQFK----DFSQKTFQDLSKKLHQLLLYIKSLREEYFDSIRLGV
SVTYSEVEDKVLGWLKNIIDLLTDWHNQCVGDLAGIATRLTDQVRELVEIYSEEYYGLIT
DIEGKGKQKIMELSSAAQEKIRYWSAAAKRKIDEHNK

PF12491 // ENSGT00590000083139_0_Domain_6 (4658, 4716)

QLKEKLREIYGQISQSQEKLISE
AKRLIDLTIENYSAFLQYLSELLRWLEQ-VTAESIKPYVAVRQGELRIQV----------
------------------------------------------------------------
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--------------------------

-----------------------------------------------MGPPRP-------
------ASLL-LLLLL-LATTCAGAREEVPGTVG-QSCPRDATL

PF01347 // ENSGT00590000083139_0_Domain_0 (105, 673)

FKHLRKYVYSYEAESS
SGVPGTADSRSSTKINCKVELEVPQLCSFILKTSHCSLKEVYGFNPEGKALLKKAKNSEE
FAAAMSKYEL-RLAVPEGKQVLLYPEKEEPKHILNIKRGIISALLLPPETEETKQVL---
YLDTVYGNCSSDLTIKKGREHVATEISIERN----LEKCDRFQPISTGVSPLALIRGMTR
PLSTLIGSSQSC-QYTLDPKRKHVSEAICKEQHLFLPFSYKNKYGMMAQVTQTLKLEETP
--KINSRFFNEG-AEAVGLAFESTKSTSPPKQ-AEAIVKTLQELQKLHVSEQNAQRANLF
HRLVTELRGLSSEAVATLLPKLMEVSS--PITLQALVQCGQPQCYTHILRWLKNEKANPL
LIDVVTYLVALIPEPSAERLREVFNTAKEQQSRATFYALSHVINNYHR-TNPTGTQDL-L
EIADYLLEQIRDNCTGNEDHTYLSLRVIGNIGRTMEQLTPKLTSSVLKCIKSTQPSLLIQ
KAAIQALRKVELGDQVREVLLQTFLDNVSPGEKRLAAYLMLMRAPSQSDINKVTQLLPGE
KNEQVKNFVASH

ENSGT00590000083139_0_Linker_0_3 (673, 709)

LANILHSEESYIQELKKLVEEALKNSQ-LPTIMDFK

PF09172 // ENSGT00590000083139_0_Domain_3 (709, 1018)

KFSRNYHFSKSI
SLPSLD-PVSTTIEGNLIFDPNNYLPKESMLKTTLRVFGFAPADLFEIGLEGKGFEPTLE
ALFGKQGFFPDSVNKALYWVDGQVPDRVSKVLVDHFGYTKDERREQDMVNGIMFSLENLI
KDLKSKEFPEARAYLHILGEELGFVKLHDLQLLGRLLLNGVRTLQGIPQMIT-EIIRKGS
KNDLFLHYIFMDNAFELPTGLGLQLQVSSSGVLTPGVKAGVKLEVA-QMQAELVTKPSVS
VEFVTNMAIIIPDFARSGVQMNTNFFHETGLEARVALRAGQLRLIIPSPKRPVRLFS

ENSGT00590000083139_0_Linker_3_5 (1018, 1044)

ASN
TLHLVSTT----KTEAIPPLIEN

PF06448 // ENSGT00590000083139_0_Domain_5 (1044, 1156)

RQSWSTCKPFFIGLNYCTTV-AYSNASSTDSSSYYPL
TGDTRFELDLKPTGEVEQYSASTSYELQRDGDALVDMLKFVTQAEGVKQTKATMMFRYNR
QSKTLSSEIQIPDFD

ENSGT00590000083139_0_Linker_5_6 (1156, 4658)

IELGTILRVSEKSTMEKKAYKLTLDLQNKKITEVTLTGHVSYERK
EEGRIKGVISIPRLQAEARSDILTHWSPSKLLLQMDSS--ATAYGSTISKRVVWRYDEEK
IEFEWNAGTNMDTKKAASNFPV----DLSDYPKSLHTYAKSLLDHRVPQTDMTFRHMGSK
LIGATNTWLQEASRNLPYAQNLQDHLSGLQELYLQKMQLPHIHIPEKLFLKSDGRIKYTL
NQNSVNIEIPLPFGGKSSKDLKMLETIWTPALSFQPVGFYLPSREVRIPTFTIPKLYQLQ
VPLMGVLDLSTNIYSNLYNWSASYTGGNTSTDQ--HWSLQAQYHVKADSVVDLLSYSVQG
SGKTTCDRRNAFTLSGDGSFHHKF-LDSNVRFSYTENTGNNPASKGL---LTFDTSSAWG
PQISASVHLDSKKKQHVYVKEVKIDGQFRASSFYTKGTYDLSYQKDPTTGRLSGESNLRF
NSSYLQGTNQITGRYEDGTVSLTSTSDLQGGLMKNTASLKYENYELSLKSDTNGKYEDFA
TSNKVDLTFSKQSALLRSEYQANYKALRFFTLLSGSLNSHGLELNADILGTDKINSGAHK
ATLRITQDGLSTSATTNLKYSPLVLENELNTALGLSGASLKLTTNGRFREHNAKFSLDGK
AALAEVSLGSAYQAMILGVDSKNIFNFRINQEGLKLSNDMMGSYAEMKLDYSNSLNIAGL
SLDFSSKLDNIYSSDKFYKQNFNLQLQPYSLVTTLNNDLKFNTLDMTNKGNLRLEPLKLN
VGGTIKGAYENNEIKHIYTLSYADLS-ASYKADT---IAKVQGTEFSHRLNTNIAGLAST
VDISTNYNSDSLHFSNVFHSAMAPFTITVDTHTSGNGKLILWGQHTGQLYSKFLMKAEPL
AFTFSHDYKGSTSHHLLSRRSMNTALDHKVSALLTLAEQTGTWKLKTQLNQNEYSQNFDA
YNTKDKVGVELNGRGLADLTVLDSTITVPLLLSEPINVIDALEMRDTVDQPQEFTVVASV
KYDKNQNHHTINLPFFNILPEYFEKTRLVGIVALEAIQRELKHININQPMRKYGAALDKF
PQQVNDYLSTFSWERQVLSAKKKLSDFMEDYRITENDVRIALDNAKINLNEKLTQLQTYV
IQFDQYIKDNYDLHDFKTAIARIIDEIIATLKILDERYHIHVNLVKKIHDLHLFIEKIGF
NKTRSSTASWFQNVNINYQIRLWIQEKLQQLKAQIQNIDIQHLAEKLKQQVEDIDARVLL
DQLRTTIPFQEIKEVIEHVKYCVKSLFEDFEVTKEINAFRAMVHELIKMYKIDEHIQVLM
DNSVHLAHQYKLQETVQKLSSILQQVKIQDLLETLTWFIDDTLKQLEALSFQQLIEEVNK
FLDMLVKRLRSFDYHHFLDETNKNLHEVTQRINGKIQALELPQKFTAL-KLLSEDIKALI
SVHLENLKATKITLFFDWLQGTLSSTPIVHMKAKFHETLEDVRDRMYQMDVQQEIQRYLF
LVGQVYSTLVTYISDWWDLAAKNLTDFAEQYSIQDWAKNLKALVEQGFTVPEIQTTFGTL
PAFEVSLRALQEATYQTPDFIVPLTDLKIPSVQINFKKLKDIEIPSRFSTPEFTVLNTFH
VPSFTIDLVEIKAKIIRTIDQMLNSELQWPVPEVYLRDLNGVETMLARITLPDLYLPEIR
IPEFVIPNLNLTDFQVSDLHIPEFQLPHIPHTVEVPAFGKLHGILKIQSPLLILEANANI
QNITT-SENTAEMEASFTAKGESKFEVLNFDFQANAQLSDPEI--NPLVLKESVRFSSKY
LKTEHGSEVLFVGNSIEGKSNTVAGLYTGKNTLKLSNDVLLKVNNQLTLNSNTKYFHELN
IPKLDFSSQADLRSEIKTLLEASHIAWRSSGKGSWKLACHRFSDEGTHESQISFTVEGPI
TSFGLSNEIRSKHLRVNQSMVYESAFLKFSKFEIHSQAECQYVGRSVLTAKGMVLPRERK
AEITGNHDAHLNGKVIGTLKNSLFFSAQPLEITASTINEGNLRVSFPLKLTGKIDFLNNY
ALLLSPSAQQASWQASARFNQYKYNQNFSAVNNERSTEAHIGINGEANLDFLNIPLTIPE
MT--LPYTRLTVPQ-VKDISLWEKTGLKEFLKTTKQSFDLSVKAQYKKNKDKHSIPNPLD
VFYAFINRNINSFNRHFETVRDKALDFFTESYNEIKITFDKYKVEKPLDQQPRTFQIPGY
TIPV---INIEVSPFTVKMLTFGYVIPKEISTPNITILGSGISVPSYTLGLQ-FLELPAL
DVPRNILQISLPELAVSGTSNKILIPAMGNITYDFSFKSSVITLNTNVGLYNQSNIVAHF
LTFSSSVIDALQYKLEGTSSLMRKRGLKLATALSLS-NKFMEGNHDSTISFTKKNVDASL
TTTARVQLPILRMNFKQELKGNTKSKPTISSSIELKYDFNSPKLHSTAAGAVDHKLSLES
L-----TSYFSIEMSTKGDVKGSILS-RVYSGSLASEASTYVNSKGTRSSVKLQGASKVD
DIWNLEVKENFAGEATLLRIYTIWEHHTKNHLQLEGLILTSGEHTSKATLELSPWNIAAL
VQVHTRQPSSLLNIHYLSQEVSLNANTENQKISWKSQVQVHSGSLQNNLQLSNDKEEARF
DISGSVEGYLSFLKYTVLPVYDMSLWDLLKLDVTTSINRKQYLRASTALVYTKNPNAYPV
SIPVQELTDKFI--IPGLKLNNLKSAHVTPAFQVPFTDLRFPSYTLDFSEIKIYKKLSTS
SFSLNIPTLPKVKFPKVDVLTQYSNPETSSVPFFEVTVPAYQLTVSPFTLPKSISVGSAV
LDLDVVASYIADFEVPTVTMPEQTIEIPSIKFSVPAGISLPSFGTLTARFGVASPLYNAT
WSAGLKNKEDRVETFLDSTCSSTIQFLEYDLNVVGTHKIEDGMLVCSTKGSFAHRDLSAE
YEENGKYHGLEYWDGKIILNITSPTLTDVYLRYQQSKN-HLFSSLASPAIGTVALEQENI
NT-SLKSNL---YYR-PQSSPDKKLNIFKIEKR--DLESDEDVQIKANWEEEAVS-ELLR
SLKDNVPKATGAFYDYVNKYHQEYTGLDLRDASLKLRKGLQNSADQAYQGAVRQIDEVD-
-RGLRKIARGTTKTYQQWKDRAQSLYQKLL-AQEDQGDFQGLRNKVFDSVIGVTQEYNVT
VKRAVDSLIKSLKFTRFQLPGRARNYTGDELCNMVMTEVGEVLSQIYSKIHSGLEILLSY
FQDLMEKSKLNKARKIKFTFDSVKYQ---------LTDVVSEYGEQLK----SLSQDVQK
ALSDLHSINI-TEILSELQIFL-EGIFQEIEEELTRLKEKKLADFINDIQQNINTTFNIY
APLGFRLLKENLDSPFGMLN----EFIQNTLWEASQELQQLHQYIKALRKEYFDPSMVGW
TVKYYELEEKVINLIKNLVDVLKDFHSKYTVSATDFASQLSSQVEQFVQEDIQEYLSILA
DADGKGKEKIAQLSSRAQEIIKSWAVTMKEIISDYHQ

PF12491 // ENSGT00590000083139_0_Domain_6 (4658, 4715)

QFIYKLQDFSDQLSDYYEKFIAE
TERLIDLSIQKYHMFLRYIMKLLKELQS-DTVNDMRPYIKVAPGEFTITF----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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--------------------------

-----------------------------------------------MGPPRP-------
------ALLPPLALGLLL-LLGAGAQDEVLENGS-PACPKDATR

PF01347 // ENSGT00590000083139_0_Domain_0 (105, 673)

FKHLRKYVYNYEAESS
SGVPGTADSRSATKINCKVELEVPQLCSFILKTSQCTLKEVYGFNPEGKALLKKTKNSEE
FAAAMSKYEL-RLAVPEGKQVFLYPEQGEPKHILNIKRGIISALFVPPETEEAKQVM---
FQDTVYGNCSTQFTVKTRKGNVATEISTERN----LQQCDHFKPISTGVSPLALIKGMSR
PLSTLISSSQSC-QYTLDSKRKHVSEAICKEQHLFLPFSYKNKYGMMAHITQTLKLEDTP
--KINSRFFGEG-AEKVGLAFESTKSTSLPKQ-ADAVLKTLQELKKLSDSEQNAQRANLF
NKLVTELRGLNNEAVTSLLPRLIEVSS--PITLQALVQCGQSQCYSHILQWLKQMHAKPL
LVDVVTYLVALVPEPSAQRLREIFNTAREQRSRATLYALSHVVNSYHK-THPTETQDL-L
DIANYLEEQIQNDCTGDEDYTDLILRVIGNMGQTMEQLTPTLKSSVLKCIKSTKPSLLIQ
KAAIQALRKMELKDEEQGVLLQTFLDGASPGDKRLAAYLMLMRTPSQSDISEIIQLLPRE
QNEQVKNFVASH

ENSGT00590000083139_0_Linker_0_3 (673, 709)

IANILNSEELYIQDLKTLVKEALRESQ-LPTLMDFR

PF09172 // ENSGT00590000083139_0_Domain_3 (709, 1017)

KFSRNYQISKSV
SLPSLN-SASAKIEGNLIFDPNNYLPKESMLKTTLTVFGFAAADLFEIGLEGKGFEPTLE
ALFGKQGFFPDSVNKALYWVNGQVPDHVSKVLEDHFGYTKDDKREQDMVNGIMLNVENLI
KDLKSKDVPEARAYLRILGEELGFARLRDLKFLGELLLISARTLQGIPQMIA-EAIRQGS
KNDFFLHYIFMDNAFELPTGAGLQLQMSSSGVITPGTKAGVKLEVA-NMQAELVTKPSVS
VEFVTNMGMIIPDFARSGVQMNTNFFHESGLEARVSLRAGQLKFIIPSPKRPVKLF

ENSGT00590000083139_0_Linker_3_5 (1017, 1044)

SGSN
TLHLVSTT----KTEAIPPLIEN

PF06448 // ENSGT00590000083139_0_Domain_5 (1044, 1156)

RQSWSACKPFFTGLNYCTSG-AYSNASSTDSASYYPL
TGDTRFELELKPTGEVEQYSVSATYELQKEDSALVDTLKFVTQTEGVKHTEATMTFRYNR
QTVTLSSEVQIPDFD

ENSGT00590000083139_0_Linker_5_6 (1156, 4658)

VDLGTILRVINESVKDKISYKLTLDIQNKKITEVAVMGHLSCDTK
EEGKIKGVISIPHLQAEARSEILTHWSSTKLLLQMDSS--ATAYGSTVSKRVAWRYDEEK
IEFEWNTGSNVDTKKVASNFPM----DLSDYPRSLLVYANSLLDHRVPQTDMTFRHMGSK
LIVATNAWLQKASGSLPYAQTLQDHLDSLKELNLQQMGLPDFHIPENLFLKSDGRVKYTL
NKNSMKIEIPLPFGGKSSKDLKVLETIRTPALHFKPMEFHLPAQEFQVPAFTIPKSYQLQ
VPLLGVLDLSTNVYSNLYNWSASYTGGNTST-D--HFSLQARYHVKADSVVDLLSYSVQG
SGETTYDHRNTYTLSCDGSLHHKF-LDSNIKFSHVEKVGNSPVSKGL---LTFDASSAWG
PQMSASVHLGSKKKQHLYVKEVKIDGQFKVSSFYAKGTYGLSCQRDPATGQLNGESTLRF
NSSYLQGTNQITGRYEDGTLSLTSTSDLQGGLIKNVASLKYENYELTLKSDTNGKYKNFA
TSNKVDLTFSEQNALLRSEYQADYESLRFFTLLSGSLNSHGLELNADILGTDKINSGAHK
ATLRIAQGAVSTSATTNLKYSPLVLENELNAELGLSGTSVKLTTSGRFREHSAKFSLDGK
AALTEVSLGSAYQAMILGVDSKNIFNFKLSREGLKLSNDMMGSYAEMKLDHTHSLNIAGL
SLDFSSKLDNIYSSDKFYKQNFNLQLQPYSLVTTLNNDLKYSALDLTNTGKLRLEPLKLN
VGGNLKGAYQNNEIKHIYTISYAALS-ASYKADT---IAKIRGAEFSHRLSTNVAGLASA
LDVSTNYNSDSLHFSNVFHSAMAPFTMAIDTHTNCNGKLALWGEHTGQLYSQFLLKAEPL
ALTFSHDYKGSTSHHLMSRKSISTALDHKVSTLLTPAEQTGTWKLKTQFNNNEYSQDLDA
YNTKDKIGVELNGRALADLTVLDYPIKVPLVLSEPINVIDALEMRDAIDKPQEFTIVAFV
KYDKNQDVHTINLPFFKTLPEYFERNQRIIITVLEVIQKELKRIDIDQFVRKYRAALSQL
PQQVNDSLNSFSWKRQVSSAKEKLTAFTKKYGITENDLQTVLDNAKINFNEKLSQMQTYV
IQFDQYIKDNYDLHDLKITVAKIIDLIIEKLKILNEHYPICVNLEKTIHALYSFIENIDF
NKTGSSTASWIQNVDTKYQIRKWIQEKLQQLEAHIQNTDLEHFAGKLKQQVEATDVKVLL
DQLRTTIPLGRIHDVLEHVKYV-VDLTGDFEVTEKIDAFRATVYKLIKAYAVDQQIQVLM
DKSVQLAHQYKLKESVQKLSNVLQQIEIKDYFEKLIRFIDDAVKQLDALSLKKFVEEVNK
FLDMLVKKLRSFDYHQFVDETNNKISEVTQRINGKIQALELPQKAETL-KLFVEDTKTVA
SEYLESLKDIKITLIIDWLQDALDSTSLTHMKAKFQETLEDIRDRMYQMDIQQELERYLS
LVGQVYSTLVTYISDWWNLAAKNLTDFAEQYSIPDLAESVKALVEQGFTVPEIQTVFGTM
PTFEVSLRALQEATFQTPDFMVPLTDLRIPSVQINFKELKDKKIPSRFSTPEFTILNILH
IPSFTIDLVEIKAKIIRTIDQMLNSELQWPVPEVYLRDLKVEDIPFGRITLPDFYLPEIT
IPEFVIPNLNRNDFQFPNIHIPEFQLPHISHSIEVPAFGKLYSILKIQSPIFTLDANADI
QNITT-LANKADIAASIAAKGESKLEVLNFDFQANAQLSSPKI--NPLVLKESVTFSSKY
LRTEHASEMLFSRDAIEGKSDTVASLYTEKNTLEVNNGVLVKINNQLTLDSNTKYFHKLN
IPKLDFSSQADLRNEIKTLLKAGHMAWTSSGIGSWKWACPKFSDEGIHESQINFTVKELM
TYFGLSNRINSKHLRVNQNLVYESGFPHVSKFEIQSQVESQHVGRSILTAKGTALFREGK
AEITGNHDAHLNGKVIGTLKNSLSVSAHSFEITASTNNEGNLKVSFPLKLTGKIDFLNNY
ALFLSPSVQEASWQASARFNQYKYNHNFSAGNNKNTIEAHVGINGEANLDFLNIPLTIPE
MT--LPYTIITTPP-LKDFSLWEKTGLKEFLKTTKQSFDLSAKAQYKKNKDQLSITNPLC
VFYEFISQKFNSFDSHLEKAQDNALDFLTKSYNEAKIKFDKYKVEESQNNLPRTFQIPGY
TIPV---INIEVSPFTVEMLEFGYVIPKAISTPNFTLLGSDFYVPSYTLVLP-SLELPVL
RIPRNLLKLSLPDFKELGTVNDIFIPAMGNITYDFSFKSSVITLNTNAGLYNQSDIVAHL
LSSSSSVIDALQYKLEGTSSLTRKRGLKLATGLSLS-NKFVEGSHNSTVSLTKKNLEASV
TTTAKVQIPILRMNLKQELNGNTKSKPTVSSSIELKYDFNSPQLLSTAQGAVDHKLILES
L-----ASYLSIESSTKGDVKGSVLS-QEYSGTIASEASTYFNSKGTRSSVKLQGASKVD
DIWNFQVKENFAGEATLQRIYAVWERNMKNHLQLEGLFSSHGEHTSKATLELSPWKMSAL
VQVHASQPNSLLNVPSLSQEVALHANTKNQKVSWKSEVQVHSGSVQNHIELSNDPKEAHL
DIAGALEGHLSFLKYVMLPVYEKSLWDLLKLDITTSIDRRQYLHASTALVYTKNPNGYPF
SVPVKVLDNEFI--IPGLKLNDLNSVLIIPAFQVPFTDLQVPSYKLDLSEIKIYKQLRTS
SFALNLPTLPKVEFPEVAVLTKYSQPEDSSVPFFEITVPKSQLTVSQFTFPISISVGNAV
WDLNEMASKIADFELPTIIMPEQTVEIPAIEFSIPAGIFIPSFGALTARLGVASPLYNAT
WSAGLKNKGDHVETFLDSTCSSTIQFLEYDINVVGTHKIENGMLVCKTKGAFAHRDFSAE
YEENSKYKGLQEWKREVHLDITSPAFTDLHFRE---------KAAASPAIGTVGIDLEKD
D-EFLKWNL---YYRSPQSSPDKKFTIFKTELR--YQESNEEIQIKVNWEEGAPS-RLLT
SLKDKVPKATGALYNYVNKYHQEHTGLTLKDASSKARRSLQNKAEWAYQGAMRQIDKMD-
-TQLWKVANDATETYQEWKDKVQTLY---------------LKANVFDSLLRITQEYRMT
VQRLIDSFITFLNSTRFQLPGKAGMYTRDELGTMAMREVVEVLSRIHLNVHNGLEILLSY
FQDLV----------IKFPFVLRRYD---------LIDIILGCRKLLK----SSSQDVQK
ALNDLQSVKI-TKMLSDLQDIL-QRVFQEIEGKIKHLK-KKFTYLTNDIQQEINTIFNKH
IPYAFGFLKEIIYLDFVKFH----ELVQNKLEETSQELQQIQQYIKALREEYFDSSVVGW
TVKYYELEKKIVNLIKNLVLALKDFHSKYTVSAAGFVSQLSGQVKQSMYRAVQEYLSILT
DADGKGKEKIAELSATAQEIIKSLTVAMKEIISDYHQ

PF12491 // ENSGT00590000083139_0_Domain_6 (4658, 4716)

QFRYKLQDFSDQVSDYYEKFIAE
SERLIDLSIQNYHMFLRYITELLKKLQS-TTA--MSPYIKLAPGELTVTL----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------

-----------------------------------------------AVPPQPAIFFFFF
FLLALPALLLLLLAFF-----FFFFFAAALRAQR-EREGADTTRFFFFFF

PF01347 // ENSGT00590000083139_0_Domain_1 (111, 224)

FTYNYEAESS
SGVPGTADSRSATRINCKVELEVPQLCSFILKTSQCTLKEVYGFNPEGRAFFFFFFYSEE
FA---------ALVIPEGKQVFLYPEKDEPTHILNIKRGIISA

ENSGT00590000083139_0_Linker_1_2 (224, 615)

FFFFFFSEETKQVL---
FLDTVFFFFFFHFTVKTRKGNVATFFFFFFF----LGQCDRFKPIRTGFFFFFFFKGMVS
PMSAL--SSQSC-QYTLVFFFFFFAEAICKEQHLFLSFDTFF------------------
---------FFF-FLKVGLAFESTKSTSFFFF-FFSVLKTLQELKKLTIFFFFFFRANLF
HKLVTELRFFFFFFFTSLLPQLIEVSR--------YLMCGQPQCSFFFFFFLKRVHANPL
LIDVVFFFFFFFPEPSAQQLREIFIFFFFFFSRATLYALSHASTWPP-----LRWQWL--
--QSIFWEPLLD-------------SALGNTGKKIQYQH--LKSDY----REIRPVL---
KKELADNASVCQAR

PF01347 // ENSGT00590000083139_0_Domain_2 (615, 673)

SDQEVLLQTFLDDASPGDKRLAAYLMLMRSPSQADINKIVQLLPRE
QNEQVKNFVASH

ENSGT00590000083139_0_Linker_2_3 (673, 709)

VANILNSEELDIQDLKKLVKEALKESQ-LPTVMDFR

PF09172 // ENSGT00590000083139_0_Domain_3 (709, 1017)

KFSRNYRLSKSI
SLPSLD-PASAKIEGNLIFDPNNYLPKETMLKTTLTAFGFASADLFEIGLEGKGFEPTLE
ALFGKQGFFPDSVNKALYWVNGQVPDGVSKVLVDHFGYTKEDKREQDMVNGMMFTVQKLI
EDLKSKEVPEARAYLRILGEELGFARLHDLQLLGKLLLTGARTLQGIPQMIG-EVIRKGS
KNDFFLHYIFIENAFELPTGAGLQLQISSSGVTAPGIKAGVKLEVA-NMQAELVAKPSVS
VEFVTNMGIIIPDFARSGVQMNTNLFHESGLEARVALKAGQLKFIIPSPKRPVKLL

ENSGT00590000083139_0_Linker_3_5 (1017, 1044)

SGSN
TLHLVSTT----KTEVIPPLIEN

PF06448 // ENSGT00590000083139_0_Domain_5 (1044, 1156)

RQSLSVCKQLFTGLNYCTSS-AYSNASSTDSAPYYPL
TGDTRLELELRPTGEVEQYSVSATYELQREDRALVDTLKFVTQAEGVKQTEATMTFKYNR
QSMTLSSEVQIPDFD

ENSGT00590000083139_0_Linker_5_6 (1156, 4658)

VDLGTILRVNDESTEGRKSYRLTLDIQNKKITEVTLMGHLSCDTK
EEGKIKGVISVPRLQAEARSEIIAHWSPAKLLLQMDSS--ATAYGSTVSKRVAWHYDEEK
IEFEWNTGTNVDTKKMTSNFPV----DLSEYPRSLHMYADRLLDHRVPQTDMTFRHVGSK
LIVAMNSWLQKASGNLPYTQTLQDHLNSLKELNLQNMGLPDFHIPENLFLKSDGRVKYTL
NKNSLKVEIPLPFGGKSSRDLKMLETVRTPALHFTSVDFHLPSREFQVPTFTIPKLYQLQ
VPLLGVLDLSANVYSNLYNWSASYTGGNTST-D--HFSLQARYHMKADSVVDLLSYNVQG
SGEATYDHKNTFTLSSGGSLRHKF-LDSNIKFSHVEKLGNNPVSKGL---LIFDASSSWG
PQMSASVHLDSKKEQHLFVKEVKIDGQFRVSSFYAKGTYGLSCQRDPNTGRLNGESNLRF
NSSYLQGTNQITGRYEDGTLSLISTSDLQSGIIKNTASLKYENYELTLKSDTNGKYENFA
TSNKMDMTFSKQNALLRSEYQADYESLRFFSLLSGSLNSHGLELNADILGTDKINSGAHK
ATLRIGQDGVSTSATTNLKYSPLVLENELNAEIGLSGASMKLTTNGRFRDHNAKFSLDGK
AALTELSLGSAYQAMILGVDSKNIFNFKISQEGLKLSNDMMGSYAEMKFDHTNSLNIAGL
SLDFSSKLDNIYSSDKFYKQTFNLQLQPYSLVTTLNNDLKYNALDLTNNGKLRLEPLKLH
MAGNLKGAYQNNEIKHIYTISSAALS-ASYKADT---VAKVQGVEFSHRLNTDIAGLASA
IDISTNYNSDSLHFSNVFHSVMAPFTMTIDTHTNGNGKLALWGEHTGQLYSKFLLKAEPL
AFTFSHDYKGSTSHHLMSRKSISTSLEHKVSALLTPAEQTGTWKLKTQFNNNEYSQDLDA
YNTKDKIGVELSGRALADLTLLDYPIEVPLLLSEPVNVIDALEMRDAVEKPQELTIVAFV
KYDKNQDVHTINLPFFETLQEYFERNQRTIIVVLENMQRHLKRINIDQFVRKYRAALGKL
PQQANDYLNSFNWERQVSRAKEKLTALTKKYRITENDIQIALDDAKINFNEKLSQLQTYM
IQFDQYIKDNYDLHDLKIAIANIIDQIIEKLKSLDEHYHIRVNLVKTIHDLHLFIENIDF
NKIGSSTASWIQNVDTKYQIRIRIQEKLQQLKRHIQNIDIQHLAGKLKQHVEAIDVRVLL
DQLGTTISFERINDVLEYVKHFVINLIGDFEVAEKINAFRAKVHELIERYEVDQQIQVLM
DKLVELAHQYKLKETIQKLSNVLQQVKIKDYFEKLVGFIDDAVKHLDELSFKTFIEDVNK
FLDMLIKKLKSFDYHQFVDETNNKIRELTQRLNGEIQALELPQKTEAL-KLFLQETKATV
AMYLESLQDTKITLIIDWLQDALSSASLAHMKAKFRETLEDTRDRIYQMDIEQELQRYLS
LVGQVYSTLVTYISDWWTLAAKNLTDFAEQYSIQDWAKHVKALVEQGFTVPEIKTILGTM
PAFEVSLQALQKATFQTPDFIVPLTDLRIPSVQINFKELKDIKIPSRFSTPEFTILNTFH
IPSFTIDFVEIKVKIIRTIDQMLNSELQWPVPEVYLRDLKVEDIPLARISLPDFHLPEIA
IPEFVIPNLNLNDFQVPDLHIPEFQLPRISHTIEVPTFGKLYSILKIQSPLFTLDANADI
GNGTT-SANEAGIAASITAKGESKLEVLNFDFQANAQLSNPKI--NPLALKEFVKFSSKY
LRTEHGSEMLFFGNAIEGKSNTVASLHTEKNTLELSNEVIVKINNQLTLDSNTKYFHKLN
IPKLDFSSQADLRNEIKTLLEAGHIAWTSSGKGSWKWACPRFSDEGTHESQISFTIEGPL
TSFGLSNKINSKHLRVNQNLVYESGSLNFSKLEIQSQVDSQHVGHSVLTAKGTALFGEGK
AEFTGRHDAHLNGKVIGTLKNSLFFSAQPFEITTSTNNEGNLKVSFPLRLTGKIDFLNNY
ALFLSPSAQQASWQVSTRFNQYKYNQNFSAGNNKNIMEAHIGINGEANLDFLNIPLTIPE
MP--LPYTTITTPP-LKDFSLWEKTGLKEFLKTTKQSFDLSVKAQYKKNTHRHSITNPLA
VLYEFTSQNIKSFDKHFEKARNNALGFVTKSYNDAKIKFDKYKAEKSHDELPRTFQIPGY
TVPV---VNVEVSPFTVEMSAFGYGIPKAVSMPSFTILGSNIRVPSYTLILP-SLELPVL
QVPRNL-KLSLPDFKELCTISHIFIPAMGNITFDFSFKSSVISLNTNAEVFNQSDIVAHL
LSSSSSVIDVLQYKLEGTTRLTRKRGLKLATALSLS-NKFVEGSHNSTVSLTKKNMEASV
ATTAKVQIPILRINFKQELNGNTKSKPTVSSSMEFKYDFNSSMLYSTAKGAVDHKLILES
L-----TSYFSIESSTKGDVKGSVLS-RDYSGTVASEANTYLNSKSTRSSVKLQGTSKID
DIWNLDVKENFAGEATLQRIYSLWEHSMKNHLKLEGLFFTNGEHTSKATLELSPWEMSAF
VQVHASQPNSFLDIPHLGQEVALNANTKNQKIRWKNEVRVHSGSFQNHVELSNDQEKAHL
DIAGSLEGHLRFLKNIILPVYGKSLWDFLKLDVTTSIGRRQHLRVSTAFVYTKNPDGYSF
SIPVKVLADEFI--IPRLKLNDLNSVLVMPTFHVPFTDLQVPSYKLDFREIKIYKKLRTS
SFALNLPALPEVKFPEVDVLTKYSQPEDSLIPFFEITVPESQLTVSQFTLPKSVSVGSAV
LDLNAVANKIADFELPTIIMPEQTIEIPSIKFSVPAGIFIPSFQALTARFEVDSPLYNAT
WSASLKNKADHVETVLDSTCSSTMQFLEYKLNVVGTHRIEDGMLASKTKGTFAHHDFSAE
YEEDGKYEGLREWERKVHLDIKNPAFTDLHLRYQKDKK-GVSTSAASPAIGTMGMDV---
--DFSKWNI---YYS-PQSSPDKKLTIFKTELR--FRESDEEIQIKVNWEEEAAS-GLLT
SLKDNVPKATGALYDYVNKYHWEHTGLTLREASSKLRRNLQNNAEWVYQGAIRQIDDID-
-LRFQKAASGTTGTYQEWKDKAQNLYQELL-TQEGQTSFQGLKDKVFDGLVRVTQEFHTK
VKHLIDSLIDFLNFPRFQFPGKPGTYTGEELCTMFLREVGMVLSQVCLKVHNGSEILFSY
FQDLV----------ITLPFELRRHK---------LIDVISMCRERLK----VLSEEAQE
VFKDIQSLKT-TEVLRNLQDVL-QFIFQLIEDNIKELKEMKFTHLINYIQDEINTIFNDY
IPYVFKLLKENLCLNLHKFN----EFIQNELQGASQELQQIHQYIMALREEYFDPSVVGW
TVKYYELEEKIVRLIKNLLVALKDFHSEYIVSASDFTSQLSSQVEQFLHRNIQEYLSILT
DPDGKGKDKIAELSTTAQEIIKSQAIAMKEIISDYHQ

PF12491 // ENSGT00590000083139_0_Domain_6 (4658, 4716)

QFRYKLQDFSDQLSDYYEKFIAE
SKRLIDLSIQNYHTFLIYIMELLKKLQS-TTV--MNPYVKLAPGELTIIL----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------

-----------------------------------------------MGPPRPALL----
AL---PALL-LLLAGARAEEE----M---LENVS-PVCPRDATR

PF01347 // ENSGT00590000083139_0_Domain_0 (105, 673)

FKHLRKYTYNYEAESS
SGVPGTADSRSATKINCKVELEVPQLCSFIMKTSQCTLKEVYGFNPEGKALLKKTKNSEE
FAAAMSRYEL-KLAIPEGKQVFLYPEKDEPTYILNIKRGIISALLVPPETEEAKQVL---
FLDTVYGNCSTHFTVKTRKGNVATEISTERD----LGQCDRFKPIRTGISPLALIKGMTR
PLSTLISSSQSC-QYTLDAKRKHVAEAICKEQHLFLPFSYKNKYGMAAQVTQTLKLEDTP
--KINSRFFGEG-TKKMGLAFESTKSTSPPKQ-AEAVLKTLQELKKLTISEQNIQRANLF
NKLVTELRGLSDEAVTSLLPQLIEVSS--PITLQALVQCGQPQCSTHILQWLKRVHANPL
LIDVVTYLVALIPEPSAQQLREIFNMARDQRSRATLYALSHAVNNYHK-TNPTGTQEL-L
DIANYLMEQIKDDCTGDEDYTYLILRVIGNMGQTMEQLTPELKSSILKCVQSTKPSLMIQ
KAAIQALRKMEPKDKDQEVLLQIFLDGASPGDKRLAAYLMLMRSPSQADINKIVQLLPWE
QNEQVKNFVASH

ENSGT00590000083139_0_Linker_0_3 (673, 709)

IANILNSEELDIQDLKKLVKEALKESQ-LPTVMDFR

PF09172 // ENSGT00590000083139_0_Domain_3 (709, 1017)

KFSRNYQLYKSV
SLPSLD-PASAKIEGNLIFDPNNYLPKESMLKTTLTAFGFASADLFEIGLEGKGFEPTLE
ALFGKQGFFPDSVNKALYWVKGQVPDGVSKVLVDHFGYTKDDKREQDMVNGMMLSVDKLI
KDLKSKEVPEARAYLRILGEELGFARLHDLQLLGKLLLMGARTLQGIPQMIG-EVIRKGS
KNDFFLHYIFMENAFELPTGAGLQLQISSSGVIAPGTKAGVKLEVA-NMQAELVAKPSVS
VEFVTNMGIIIPDFARSGVQMNTNFFHESGLEAHVALKAGQLKFIIPSPKRPVKLL

ENSGT00590000083139_0_Linker_3_5 (1017, 1044)

SGGN
TLHLVSTT----KTEVIPPLIEN

PF06448 // ENSGT00590000083139_0_Domain_5 (1044, 1156)

RQSWSVCKQFFTGLNYCTSG-AYSNASSTDSASYYPL
TGDTRLELELRPTGEIEQYSVSATYELQREDRALVDTLKFVTQAEGAKQTEATMTFKYNR
QSMTLSSEVQIPDFD

ENSGT00590000083139_0_Linker_5_6 (1156, 4658)

VDLGTILRVNDESTEGKKSYRLTLDIQNKKITEVALMGHLSCDTK
EERKIKGVISIPRLQAEARSEILAHWSPAKLLLQMDSS--ATAYGSTVSKRVAWHYDEEK
IEFEWNTGTNVDTKKMTSNFPV----DLSDYPKSLHMYANRLLDHRVPQTDMTFRHVGSK
LIVAMNSWLQKASGSLPYTQTLQDHLNSLKEFNLQNMGLPDFHIPENLFLKSDGRVKYTL
NKNSLKIEIPLPFGGKSSRDLKMLETVRTPALHFKSVGFHLPSREFQVPTFTIPELYQLQ
VPLLGVLDLSTNVYSNLYNWSASYSGGNTST-D--HFSLRAHYHMKADSVVDLLSYNVQG
SGETTYDHKNTFTLSCDGSLRHKF-LDSNIKFSHVEKLGNNPVSKGL---LTFDASSSWG
PQMSASVHLDSKKKQHLFVKEVKIDGQFRVSSFYAKGTYGLSCQRDPNTGRLNGESNLRF
NSSYLQGTNQITGKYEDGTLSLTSTSDLQSGIIKNTASLKYENYELTLKSDTNGKYKNFA
TSNKMDMTFSKQNALLRSEYQADYESLRFFSLLSGSLNSHGLELNADILGTDKINSGAHK
ATLRIGQDGISTSATTNLKYSLLVLENELNAELGLSGASMKLTTNGRFREHNAKFSLDGK
AALTELSLGSAYQAMILGVDSKNIFNFKISQEGLKLSNDMMGSYAEMKFDHTNSLNIAGL
SLDFSSKLDNIYSSDKFYKQTFNLQLQPYSLVTTLNSDLKYNALDLTNNGKLRLEPLKLH
VAGNLKGAYQNNEIKHIYAISSAALS-ASYKADT---VAKVQGVEFSHRLNTDIAGLASA
VDMSTNYNSDSLHFSNVFRSVMAPFTMTIDAHTNGNGKLALWGEHTGQLYSKFLLKAEPL
AFTFSHDYKGSTSHHLMSRKSISTALEHKVSALLTPAEQTGTWKLKTQFNNNEYSQDLDA
YNTKDKIGVELSGRALADLTLLDSPIKVPLLLSEPVNIIDALEMRDAIEKPQEFTIVAFV
KYDKNQDVHTINLPFFETLQEYFERNQRTIIVVLENIQRDLKHINIDQFVRKYRAALGKL
PQQVNDYLNSFNWERQVSRAKEKLTALTKKYRITENDIQIALDDAKINFNEKLSQLQTYM
IQFDQYIKDNYDINDLKIAIANIIDQIIEILKSLDEHYHIHVNLVKTIHDLHLFIENIDF
NKSGSSTASWIQNVDTKYQIRIQIQEKLQQLKRHIQNIDIQHLAGKLKQHIEAIDVRVLL
DQLRTTISFERINAILEHVKHFVINLIGDFEVTEKINAFRAKVHELIERYEVDQQIQVLM
DKLVELAHQYKLNETIQKLSNVLQQVKIKDYFEKLVGFVDDAVKQLDELSFKTVIEDVNK
FLDMLIKKLKSFDYHQFVDETNNKIHEVTQRLNGEIQALELPQKAEAL-KLFLEETKATV
AVYLESLQDTKITLIIDWLQDALSSASLAHVKAKFRETLEDTRDRMYQMDIQQELQRYLS
LVGQVYSTLVTYISDWWTLAAKNLTDFAEQYSIQDWAKRVKALVEQGFTVPEIKTVLGTM
PAFEVSLQALQKATFQTPDFIVPLTDLRIPSVQINFKELKDIKIPSRFSTPEFTILNTFH
IPSFTIDFVEIKVKIIRTIDQMLNSELQWPVPEVYLRDLKVEDIPLARITLPDFHLPEIA
IPEFIIPNLNLKDFRVPDLHIPEFQLPHISHTIEVPTFGKLYSILKIQSPLFTLDANADI
GNGTT-SANEAGIAASITAKGESKLEVLNFDFQANAQLSNPKI--NPLALKESLKFSSKY
LRTEHGSEMLFFGNAIEGKSNTVASLHTEKNTLELSNGVIVKINNQLTLDSNTKYFHKLN
IPKLDFSSQADLRNEIKTLLEASHIAWTSSGKGSWKWACPRFSDEGTHESQISFTIEGRF
TSFGLSNKINSKHLRVNQNLVYESSSLNFSKFEIQSQVDSQHVGRSVLTAKGTALFGEGK
AEFTGRHDAHLNGKVIGTLKNSLFFSAQPFEITASTNNEGNLKVSFPLRLTGKIDFLNNY
ALFLSPSAQQASWQVNARFNQYKYNQNFSAGNNENIMEAHAGISGEANLDFLNIPLTIPE
MH--LPYTIITTPP-LKDFSLWERTGLKEFLKTTKQSFDLSVKAQYKKNKHRHSITNPLA
VLYEFISQSIKSFDRHFEKARNNALDFVTKSYNEAKIKFDKYKAEKSHDELPRTFQIPGY
TVPV---VNVEVSPFTIEMSAFGYVFPKAVSMPSFTILGSDIRVPSYTLILP-SLALPVL
HVPRNL-KLSLPDFKELCTISHIFIPAMGNITYDFSFKSSVITLNTNAELFNQSDIVAHL
LSSSSSVIDALQYKLEGTTRLTRKRGLKLATALSLS-NKFVEGSHNSTVSLTKKNMEASV
ATTAKAQVPILRMNFKQELNGNTKSKPTVSSSMEFKYDFNSSMLYSTAKGAVNHKLSLES
L-----TSYFSIESSTRGDVKGSVLS-REYSGTIASEVNTYLNSKSTRSSVKLQGTSKID
DIWNLEVKENFAGEATFQRIYSLWEHSTKNHLQLEGLFFTSGELTSKATLELSPWEMSAL
VQVHASQPSSFLDFPHFGQEVALNANTKNQKIRWKNEVWVHSGSFQSHVELSNDQEKAHL
NIAGSLEGHLRFLKNIILPVYDKSLWDFLKLDVTTSIGRRQHLRVSTAFVYTKNPNGYSF
SIPVTVLADKFI--IPGLKLNDLNSVLVMPTFHVPFTDLQVPSYKLDFREIKIYKKLRTS
SFALNLPTLPEVKFPEVDVLTKYSQPKDSLIPFFEITVPESQLTVSQFTLPKSVSVGIAA
LDLNAVANKIADFELPTIIMPKQTIEIPSIKLSVPAGIFIPSFRALTARFEIDSPLYNAT
WSASLKNKADHVEIVLDSTCSSTIQFLEYELNVVGTHKIEDGMLASKTKGTFAHRDFSTE
YEEDGKYEGLQEWEGKAHLNIKSPAFTDLHLRYQKDKK-GISTSAASPAIGTVGMDMDED
D-DFSKWNF---YYS-PQSSPDKKLTIFKTELR--VRESDEETQIKVNWEEEAAS-GLLT
SLKDNMPKATGALYDYVNKYHWEHTGLTLREASSKLRRNLQNNAEWVYQGAIRQIDDID-
-MRFQKAASGTTGTYQEWKDKAQNLYQELL-TQEGQASFQGFKDKVFDGLVRVTQEFHMK
VKHLIDSLIDFLNFPRFQFPGKPGTYTREELCTMFIREVGTVLSQVYSKVHNGSEILFSY
FQDLV----------ITLPFELRRHK---------LIDVISMYRELLK----DLSKEAQE
VFKAIQSLKT-IEVLRNLQDLL-QFIFQLIEDNIKELKEMKFTNLINYIQDEINTIFNDY
IPFVFKLLKENLCLNLHKFN----EFIQNELQEVSQELQQIHQYIMALREEYFDPSIVGW
TVKYYELEEKIVSLIKNLLVAFKDFHSEYIVSASDFTSQLSSQVEQFLHRNIQEYLSILT
DPDGKGKEKIAELSTTAQEIIKSQAIAMKEIISDYHQ

PF12491 // ENSGT00590000083139_0_Domain_6 (4658, 4716)

QFRYKLQDFSDQLSDYYEKFIAE
SKRLIDLSIQNYHTFLIYIMELLKKLQS-TTV--MNPYMRLAPGELTIIL----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------

-----------------------------------------------MGPQRPALR----
------APLLL-LFLLLFLDTSVWAQD--------------ATR

PF01347 // ENSGT00590000083139_0_Domain_0 (105, 673)

FKHLRKYVYSYEAESS
SGVRGTADSRSATKINCKVELEVPQVCTLIMRTSQCTLKEVYGFNPEGKALMKKTKNSEE
FASAMSRYEL-KLAFPEGKRVALYPDLGEPNYILNIKRGIISALLVPPETEEDKQVL---
FQDTVYGNCSTQVTVNSRKGTVATEMSTERN----LQHCDGFQPISTSVSPLALIKGLVR
PLSTLISSSQSC-QYTLEPKRKHVSEAICNEQHLFLPFSYKNKYGIMTHVTQKLSLEDTP
--KINSRFFRGG-INQVGLAFESTKSTSPPKQ-ADAVLKTLQELKKLSISEQNAQRANLF
HKLVTELRGLSGEAITSLLPQLIEVSS--PITLQALIQCGQPECYTHILQWLKTEKAHPL
LIDIVTYLMALIPNPSVQRLQEIFNTAKELQSRATLYALSHAVNSYYAIMDHSRSPVL-E
DIAGYLMKQIDNECMGDEDRTFLILRVIGNMGRTMERVMPALKSSVLNCVRSTKPSLQIQ
KAALQALRKMEMGDEVRTILFDTFVNDVAPVEKRLAAYLLLMRSPSSSDINKIAKLLQWE
QSEQVKNFVASH

ENSGT00590000083139_0_Linker_0_3 (673, 709)

IANILNSEELYVQDLKNLIKNALVNSR-LPTIMDFR

PF09172 // ENSGT00590000083139_0_Domain_3 (709, 1017)

KFSRNYQISKSV
SIPLFD-PVSAKIEGNLVFDPSSYLPKESMLKTTLTVFGIASLDLFEIGLEGKGFEPTLE
ALFGKQGFFPDSVNKALYWVNGQVPDRVSKVLVDHFGYTKDDKHEQDMVNGIMPIVDKLI
KELKSKEIPEARAYLRILGKELGFVRLQDLQVLGKLLLNGAQTFRGVPQMIV-QAIREGS
KDDLFLHYIFMENAFELPTGVGLQLQVSSSGVFTPGIKAGVRLELA-NIQAELVAKPSVS
LEFVTNMGIIIPDFAKSGVQMNTNFFHESGLEARVALKAGQLKVIIPSPKRPVKLF

ENSGT00590000083139_0_Linker_3_5 (1017, 1044)

SGSN
TLHLVSTT----KTEVIPPLIEN

PF06448 // ENSGT00590000083139_0_Domain_5 (1044, 1156)

RKSWSTCKPFFTGMNYCTTG-AYSNASSTESASYYPL
TGDTRYELELKPTGEVEQYSASATYELLKEDKSLVDTLKFLVQAEGVQQSEATAMFKYNR
RSRTLSSEVLIPGFD

ENSGT00590000083139_0_Linker_5_6 (1156, 4658)

VNFGTILRVNDESSKDKNTYKLILDIQNKKITEVSVVGHVSYDKK
GDGKVKGVVSIPRLQAEARSEVHTHWSPTKLLFQMDSS--ATAYGSTISKRVAWRYDNEK
IEFDWNTGTNVDTKKVASNFPV----DLSRYPRMVHEYANGLLDHRVPQTDMTFRHMGSK
LIV--------------------DHLNGLSELNLPKVGLPDFHIPDNLFLKTDGRVKYTL
NKNRIEIDIPLPLGGKSSKDLKVPESVRTPALNFKSVGFHLPSQEVQIPTFTIPKTHQLQ
VPLLGILDLSTNVYSNLYNWSVSYTGGNTSR-D--HFSLQAQYRMKADSVVDLFSYSVQG
SGETTYDSKSTFTLSCDGSLHHKF-LDSKFKVSHVEKFGNNPVSKGL---LTFETSSALG
PQMSATVQLDSKKKQHLYVKDIKVDGQFRVFSLYAQGEYGLSYERDSMTGQMSGESNMKF
NSTYFQGTNQIVGMYQDGMLSVTSTSDLQDGIFKNTASLKYENYELTLKSDSSGQYENFA
ASNKLDMTFSKQSALLRSEHQANYKSLRLVTLLSGSLTSQGVELNADILGTDKINTGAHK
STLKIAQDGVSTSATTNLKYSPLLLENELNAELGLSGASMKLSTSGRFKEHHAKFSLDGR
AALTEVSLGSIYQAMILGADSKNVFNFKLSREGLKLSNDMMGSYAEMKLDHTHSLRISGL
SLDFFSKMDNIYSGDKFYKQNFNLQLQPYSFGITLSNDLKYDALVLTNNGRLRLEPLKLN
VGGNFKGTYQNNELKHIYTISYTDLVVASYRADT---VATVQGVEFSHRLNADIEGLASS
VDVTTSYSSDPLHFNNVFRFVLAPFTLGVDTHTSGDGKMSLWGEHTGQMYSKFLLKAEPL
ALTFSHDYKGSTSHNLLYKNSVSTALEHTLSALLTPAEQTSSWKFKTSLNDKVYSQEFEA
YNTKDKIGIELSGR--ADLSGLYSPIKVPFFYSEPVNVLNSLEINDAFDEPREFTIDAVV
KYDKNQDVHTISLPFFQSLPDYLERNRRGIISLLEAMKGELQRLSVDQFVRKYRVALSRL
PQQIHDYLNASDWERQVAGAKEKLTSFMENYRITDNDVLIALDSAKINLNEKLSQLETYA
IQFDQYIRDNYDAQDLKRTIAQIIDRIIEKLKMLDEQYHIRVNLAKSIHNLYLFVENVDL
NQISSSGASWIQNVDTKYQIRIQIQEKLQHLRTQIHNIDIQQLAAELKQQIEALDVPMHL
DQLRTAILFQRISVIIERVKYFVMNLIEDFKVTEKINTFRVIVRELIEKYEVDRQIQVLM
DKSIELAHRYSLSEPLQKLSNVLQQIEIKDYYDKLVGFIDDTVEWIKAVSFKNIIEELNR
LIDMSVKKLKAFDYHQFVDKTNSKIREMTQRINAEIQALELPQKTEAL-KLWVEDFKTTV
SNSLEKLKDTKVTVVVDWLQDGL-----AQIKAQFQDALEDVRDRIYQMDIQGELERCLS
LVSQVYSTVVTYISDWWTLTAKNITDFAEQYSTQKWAESVKALVEQGFIVPEIQTFLGTM
PAFEVSLHALQEANFQTPDFIVPLTDLRIPSIWINFKMLKNVKIPLRFSTPEFTLLNTFR
VRSFTIDLLEIKAKIIRTIDQMLSSELQWPLPEVYLRDLEMVNISLARLSLPDFHVPEIT
IPEFTIPNVNLKDLQVPDLHIPEFQLPHLSCTTEIPAFGKLHSVLKIQSPLFILDASANI
QNITT-SENKAEIVASVTARGESKFEALNFDFQAQAQFLELNA--NPLVLKESVNFSSKH
VRMEHEGKILVSGKALEGKSDTVARLHTEKNTVEFNNGIVVKINNQFTLDSQTKYFHKLS
VPRLDFSSKASLNNEIKTLLEAGHMAWTSSGTGSWNWACPNFSDEGIHSSKISFIVDGPI
ASFGLSNNINGKHLRVVQKLTSESGFLNYSRFEVESKVESQHVGSSILTAEGRALLGDAK
AEMTGEHNANLNGKVIGTLKNSLFFSAQPFEITASTNNEGNLKVSFPLKLTGKIDFLNNY
ALFLSPHAQQASWQLSTRFNQYKYNQNFSAINNEHNMEASIVMNGDANLDFLNIPLTIPE
IN--LPYTRFTTPL-LKDFSIWEETGLKEFLKTTKQSFDLSIKAQYKKNRDKHSVVIPLK
MFYEFMLNNVNSWDRKFEKVRDNALHFLTASYNETKIKFDKYKTENSLNQPSRTFQNRGH
TIPV---LNIEVSPFAVETLASSHVIPKAIRTPSVTIPGPNIIVPSYRLVLP-SLQLPVF
HIPRTLFKFSLPDFKKLSTIDNIYIPAMGNFTYDFSFKSSVITLNTNAGLYNQSDLVARF
LSSSSFVTDALQYKLEGTSRLMRKKVLKLATAVSLT-NKFLKGSHDSTISLTKKNMEASV
KTTANLHAPIFTMNFKQELNGNTKSKPTVSSSIELNYDFNSSKLHSAAKGGVDHKFSLES
L-----TSYLSIESFTKGNIKGSFLS-QEYSGSVANEANVYLNSKGTRSSVRLQGASNFA
GIWNFEVGENFAGEATLRRIYGTWEHNMINHLQVFSYFDTKGKQTCRATLELSPWTMSTL
LQVHVSQPSPLFDLHHFDQEVILKASTKNQKVSWKSEVQVESQVLQHNAHFSNDQEEVRL
DIAGSLEGQLWDLENFFLPAFGKSLRELLQID-----GKRQYLQASTSLHYTKNPNGYLL
SLPVQELTDRFI--IPGLKLND-------------------------FSGIKIYKKLSTS
PFALNLTMLPKVKFPGVDLLTQYSKPEGSSVPTFETTIPEIQLTVSQFTLPKSFPVGNTV
FDLNKLTNLIADVDLPSITLPEQTIEIPSLEFSVPAGIFIPFFGELTAHVGMASPLYNVT
WSTGWKNKADHVETFLDSTCSSTLQFLEYALKVVGTHRIENDKFIYKIKGTLQHCDFNVK
YNEDGIFEGLWDLEGEAHLDITSPALTDFHLHYKEDKT-SVSASAASPAIGTVSLDASTD
D-QSVRLNV---YFR-PQSPPDNKLSIFKMEWR--DKESDGETYIKINWEEEAAF-RLLD
SLKSNVPKASEAVYDYVKKYHLGHA-------SSELRKSLQNDAEH----AIRMVDEMN-
-VNAQRVTR---DTY-------QSLYKKML-AQESQSIPEKLKKMVLGSLVRITQKYHMA
VTWLMDSVIHFLKFNRVQFPGNAGTYTVDELYTIAMRETKKLLSQ----LFNGLGHLFSY
VQDQVEKSRVINDITFKCPFSPTPCK---------LKDVLLIFREDLN----ILSNLGQ-
-----QDINF-TTILSDFQSFL-ERLLDIIEEKIECLKNNESTCVPDHINM-F---FKTH
IPFAFKSLRENIYSVFSEFN----DFVQSILQEGSYKLQQVHQYMKAFREEYFDPSVVGW
TVKYYEIEEKMVDLIKTLLAPLRDFYSEYSVTAADFASKMSTQVEQFVSRDIREYLSMLA
DINGKGREKVAELSIVVKERIKSWSTAVAEITSDYLR

PF12491 // ENSGT00590000083139_0_Domain_6 (4658, 4714)

QLHSKLQDFSDQLSGYYEKFVAE
STRLIDLSIQNYHMFLRYIAELLKKLQV-ATAN

ENSGT00590000083139_0_Linker_6_7 (4714, 4827)

NGLLKRGDFEAAVKLGIACLYNEGLS-
----VSDEAYAEVNGLKASRFFSMDERLNMGSDPFIWLSICPPCFRKLRDFAGKGCWEAQ
PALAKDCAGGSQLGLEGKAFSESVCQ

PF00134 // ENSGT00590000083139_0_Domain_7 (4827, 4947)

LFQASQAVNKQQIF-SVQKGLSDTVRYILIGWLV
EVAPMKDFTSLCLHLTVECVGRYLQRKLVPRYKLQLLGIACMVICTWFISKEILTIREAV
RLTDNTYKYKDLVRVKREIISALEGKIRIPTVVDYKEVLLTLVPVTPRTQYLCSFLCELT
LSVYTPAHLASAALLLARLMHGQTQP

------------------------------------------------------------
------------------------AEDEVPESAS-PGCAKGATR

PF01347 // ENSGT00590000083139_0_Domain_0 (105, 673)

FKHLRKYVYNYEAESS
SSIPGTTDSRSATRINCKVELEVPQLCNFIVRTSQCTLKEGNGFNPKGRPSLHKTKNSEE
FAAAMSKYEL-RLAIPEGKQVLLYPEKEEPTHILNIKRGLISALLVPPETEADKQVL---
FLDTVYGNCSSDLTVNARKANVATEISIERN----LEKCDHFKPISTGVSPLALIKGMVR
PLSTLISSNQSC-QYTLDPKKKHVSEAICKEQHLFLPFSYENKYGIMTQVTQTLKLEDTP
--KINSRFFDEG-AKEVGLAFESTKSTSPPKQ-AEAIVKTIQELQTLHVSEQNAQRANLF
NKLVTELRGLNNEALTTLLPKLMEVSS--PITLQALIQCGQSQCYTHILQWLRSEKANPL
LIDVVTYLVALTPEPSAERLQEIFSTAQEQQSRATLYALSHVVNNYHK-ANPVVTQDL-L
NIADYLLEQLQDSCTGNEDHTYLILRVIGNMGRTMETVAPRLTSSILKCIQSTEPSLLIQ
KAAIQALRKMELKDEVREVLLQVFLDDASPGEKRLAAYLMLMRSPSQSDINQITQLLPRE
QNEQVKNFVASH

ENSGT00590000083139_0_Linker_0_3 (673, 709)

IANILNSEELYIKDLKKLVEGALKGSQ-LPTIMDFS

PF09172 // ENSGT00590000083139_0_Domain_3 (709, 1025)

KFSRNYHLSKSV
SLPSLD-PISGKIEGNLIFDPNNYLPKESMLKTTLTVFGLAPADLFEIGLEGKGFEPTLE
ALFGKQGFFPDSVNKALYWVDDQVPDHVSKVLVDHFGYTKDGKREQDMVNGIMLNVERLI
KDLKSKEFPEARAYLHILGEELGFVRLHDLQLLGKMLLNGVHTLAGIPQMIG-EAIRKGL
KNDLFLHYIFMDNAFELPTGLGLQLQVSSSGVITPGMKAGMKVEMA-NLLTELVAKPSVS
MEFVTNMGIIIPDFSKTGIQMNTNFFHETGLEMQIAFKAGRLKFVIPSPTRPVKLFSGSN
TLHL

ENSGT00590000083139_0_Linker_3_5 (1025, 1042)

VSTT----KTEEVAPLN

PF06448 // ENSGT00590000083139_0_Domain_5 (1042, 1156)

ESRKSWSTCKPLFTGLDYCSSG-AYSTANSPESASYYPL
SRDTRFELELKPTGEVEQYSASVSYELQREGGASVDTLTFITQTEGLKQTEAAMMFKYNR
QSTTLSSEIQIPDFD

ENSGT00590000083139_0_Linker_5_6 (1156, 4658)

VDLGTILRVSDESAMEKKSYRLTLDIQNKKITEVTLTGHVSYDKR
EEGKIKGVISIPRLQAEARSEILTQWSPTKLLVHMDSS--ATAYGLTISKKLGWRYDEEK
IEFEWNTGTNVDTKKAASNFPM----DFSDYPKSLHMYANSLLDHRVPQTDMTFRHVGSK
LMVATDTWLQKASRSLPYAQNLQDHLSGLKELYLQKMGLPDFHVPENIFLKSDGRVKYTL
NKNSVKIEIPLPFGGKSSKELKMSETIQTPDLNFKSIGFYLPSREFQVPTFTIPKLYQLQ
VPLLGVLDLSANIYNNLYNWSASYTGGNTTN-N--HWSLQAQYHMKADSVVDLLSYSVQG
SGETTYDHRNTFTLSCDGYLHHKL-LDSNMKFSHVEKIRNNPASKSV---LTFNTSTAWG
PQMSASLHLDSKKKHHLYVKEAKIDGQFTVSSFYAKGIYDLSYQRDSTTGQLRGESNLRF
NSSYLQGTNQITGRYEDGTVSLTSTSDLQDGIIKNTAFLRYENYELTLKSDTSGKHEDFA
TYNKVDMTFSKQNALVRSEYQADYKSLRLFTLLSGSLNSHGLELNADVLGTDKINSGAHK
ATLRIAQDGMSTSATTNLKYNPLVLENELNAALGLSGASVRLTTNGRFREHNAKFSLDGK
ATLTEVSLGSAYQAMILGFDSKNVFNFKISREGLKLSNDMMGSYAEMKLDYTNNLNIAGL
SLDFSSKLDNIYSSDKFYKQNFNVQLQPYSLVTTLSNDLQFNALDLTNSGKLRLEPLKLN
VGGNIKGVYQNNEIKHIYTISYADLS-ASYKTDT---VAKVQGTEFSHRLNTNIAGLASA
IDISTSYNSDSLHFSNIVHSAMAPFTMTIDALTNSNGKLSFWGEHTGQLYSKFLLKAEPL
ALTFSHDYKGSTSHHLPLKSSITTGLDHKVSALLTPAEQTGTWKVKTQLNENEYSQDFDA
YNDKDKVGVELRGRALAEPTMIDFSIPVPFLLSEYINIIDVLGMRDAVAQPQEFSVVASV
KYDKNQNVHTINLPFFESLPEYFEEKRMVIITALETIQRELKLINIDQFVKKYRTALDKL
PQQTYGYLNSLNWERQVSSAKEKLITLIENYRITENDVQIALNNTKISLNDKLSQLKTYV
IQFDQYIKDNYDLRDFKIAVAKIIDQIIEKLKILDEHYHIHVNLVKTIHDVCLFIEKTDF
NRIGNSTAFWIQNVDTKYQIKIQIQEKLQQLKTHIQNIDIQHLADQLKQQVEALDVRVLL
DKLRITIPFQRIKEIIEHVRNYVVNLMKDFEVAEKINMFGTMSHKLIKMYGIDRHIQVLM
DKLVQLAHQYKLKETVQKLSSVLQQVKIKDHFEKLVKCIDDAIKQLKAFSFKKIIEGVNR
FLDMLVKKLRSFDYHQFVDEANNKIHEVTQRLNGEIQALELPQKAKAL-RLFIEDIKATV
SVHLENLKGTQISLFFDWLQEPLNSTSLTHIKEKFQETLEDIRERVYQMDIQREVKRYLS
LVGQVYSTLVTYISDWWSLAAKNLTDFAEQYSIQYWAENLKALVEQGFTVPEIQTTFGTM
PAFEVSLRALQEATFQTPDFIVPLTDLKVPSVQINFKKLKDIEIPPKFTTPEFTILNTFH
VPSFTIDLVELKAKIIRTIDQMLSSELQWPVPEMYLRDLEGVDTILASITLPDFCLPEIT
IPEFIIPNFDFKDYQVPDLHIPEFQLPRMPHTVEVPTFGKLHSILKIQSPLFTLDANADI
QNVTT-SGNKAEIAASITARGESKLEVLSFDFQANAQLSDPKI--SPLVMKQSVRFSSKY
LKTEHESEVLFFGNAIEGKSNTVAGLHTEKNTLELSNGVLVTINNQLTLDSSTKYFHKLN
IPKLDFSSQAELRNEIKTLLESGHITWTSSGLGSWKWACNTSSDEGAHESQVSFTMKEAM
ASFGLSNKISSKHLKLSQNLVFESSFPDFSKFEIQSQVESQHVGHSVLAAKGTALLGERK
AEITGNHNAHLNGKIIGTLKNSLFFTAQPFELTASTNNEGNLKVSFPLKLIGKVDFLNNY
ILLLSPSTQQAGWQASARFNQYKYHHNFSAGNNENSVEAHIGINGEANLDFLNIPLTIPE
MT--LPYTTLTTPH-VKDFSLWEKTGLKEFLKTTRQSFDLSVKSQYKKNKDKHIIPIHF-
------------------------------------------------------------
------------------------------------------------------------
---------YMKDFQVLSTPGDIFIPAMGNITYDFSFKSGLITLNTNVGLYNQSDIVAHF
LTSSSSVIDGLQYKLEGTSSLTRKRGLKLATALSLS-NKFVEGNHDSTISLTKKNMEASV
TTSAKVQIPILRMNFKQELNGNTKSKPTVSSSIELIYDLNSPKLYSTATGRVNHKLSLES
L-----TSYFSIESSTKGDVKGSVLS-REYSGSIAGEASTYLNSKSTRTSVKLQGASKVD
GIWNLDVKENFAGETTLQRIYAIWEHNMKNSLQLEDLFSSSGEHTSKATLELSPWKMSAL
VRVHASQPNSFLEINYLDQEMSLNANTENQKVSWKSEVQVHSEFFQNNIQLFNDQEEARL
DVGSSLKVSLWFLKDIILPIYDKSLWDLLKLDVTTSIDKRQYLHAATALVYTKNPKGYHF
SVPVQELADKFI--IPRLKLSDLNSSFVIPTFQVPFTDLQVPSYTIDFSEIKLYKKLSTL
PFSLNIPMLPKVKFPKIDVLTKYSEPEDSSVPFFEIIVPASQLTVSQFTLLQSSSGDSAV
EYLNEVASKFADFELPAITIPEQTIEIPSIKFSVPAGIFIPSFGALTAHFGVVSPLYNAT
WSAGLKNKVEYVETFLNSTCSSTIQFLEYDLNVVGTHKIEDGMLVCRTKGTFAHRDISAE
YKEDNRYRGLQDWKKEIRLDITSPTFTDAHLHYQLNKN-YLSYLVASPAVGTVAFDMEDN
N-RTLKLNL---YYR-PQSSLDKKLNIFKTEWR--YRESDEKNQIKVSWEEEAVS-KLLT
SLKDNVPKATGALYDYANKYHQEHTGLDLTDASSKLRRSLQNSADWAYHSVLEKIDKAD-
-LGFQSIAKGTTRTYQQWKDKAQDLYQEMLLAHRDQGDFQGLQKDMFDRLMGVTQEYKVT
VSHQIDSLIDFLKFTKFQLPGKPGTYTKDELCTMVMKEVGQVLSQVYSKIYSGFEILFSY
FQDLMEKSELIKDLEIKIPFDSKSYK---------LIDVILEFGRVLK----SLSQKPQD
AFNNLQSINT-TEMLSDLQRYL-QRAFQKIEEEIQRLKEKKFSYLINHIQHKINIIFNKY
IPYVFEFLKRNLYLNFGKFN----ELVQNQLQEASQQLQQLHQIIKDLRKEYVDSNVVSW
TLRYYELEEEIISLIKNLVDVLKDFHSKYTVSTADLVSQLSSKVEQFVQKDIQEYLSILI
DADGKGKEKIAELSTSTQEIIKSWANAMKEIISDYHQ

PF12491 // ENSGT00590000083139_0_Domain_6 (4658, 4715)

QFRYKLQDFLDQLSDYYEKFITE
SKRLIDLSIQNYHMFLRYITELLKELQS-ATVNNMIPYIKVSPGEFTITL----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------

-----------------------------------------------MGPPRPALL----
AL---PALL-LLLAGARAEKE----M---LENVS-VVCPRDATR

PF01347 // ENSGT00590000083139_0_Domain_0 (105, 673)

FKHLRKYTYNYEAESS
SGVPGTADSRSATRINCKVELEVPQLCSFILKTSQCTLKEVYGFNPEGRALLKKTKNSEE
FAAAMSRYEL-KLAIPEGKQVFLYPEKDEPTHILNIKRGIISALLVPPETEETKQVL---
FLDTVYGNCSTHFTVKTRKGNVATEISTERD----LGQCDRFKPIRTGISPLALIKGMTH
PLSTLISSSQSC-QYTLDAKRKHVAEAICKEQHLFLPFSYKNMYGMGVQVTQTFKLEDTP
--KINSRFFGEG-TKKVGLAFESTKSTSPLKQ-AEAVLKTLQELKKLTISEQNIQRANLF
HKLVTELRGLSDEAVTSLLPQLIEVSS--PITLQALVQCGQPQCSTHILQWLKRVHANPL
LIDVVTYLVALIPEPSAQQLREIFNMAREQRSRATLYALSHAVNNYHK-TNPTVTQEL-L
DITNYLMEQIQDDCTGDEDYTYLILRVIGNMGQTMEQLTPELKSSILKCVQSTKPSLMIQ
KAAIQALRKMEPKDKDQEVLLQTFLDDASPGDKRLAAYLMLMRSPSQADINKIVQLLPRE
QNEQVKNFVASH

ENSGT00590000083139_0_Linker_0_3 (673, 709)

IANILNSEELDIQDLKKLVKEALKESQ-LPTVMDFR

PF09172 // ENSGT00590000083139_0_Domain_3 (709, 1017)

KFSRNYQLSKSV
SLPSLD-PASAKIEGNLIFDPNNYLPKETMLKTTLTAFGFASADLFEIGLEGKGFEPTLE
ALFGKQGFFPDSVNKALYWVNGQVPDGVSKVLVDHFGYTKEDKREQDMVNGMMFSVQKLI
EDLKSKEVPEARAYLRILGEELGFAKLHDLQLLGKLLLMGARTLQGIPQMIG-EVIRKGS
KNDFFLHYIFIENAFELPTGAGLQLQISSSGVTAPGIKAGVKLEVA-NMQAELVAKPSMS
VEFVTNMGIIIPDFARSGVQMNTNFFHESGLEARVALKAGQLKFIIPSPKRPVKLL

ENSGT00590000083139_0_Linker_3_5 (1017, 1044)

SGSN
TLHLVSTT----KTEVIPPLIEN

PF06448 // ENSGT00590000083139_0_Domain_5 (1044, 1156)

RQSLSVCKQLFTGLNYCTSS-AYSNASSTDSAPYYPL
TGDTRLELELRPTGEVEQYSVSATYELQREDKALVDTLKFVTQAEGVKQTEATMTFKYNR
QSMTLSSEVQIPDFD

ENSGT00590000083139_0_Linker_5_6 (1156, 4658)

VDLGTILRVNDESTEGRKSYRLTLDIQNKKITEVTLMGHLSCDTK
EEGKIKGVISIPRLQAEARSEILTHWSPAKLLLQMDSS--ATAYGSTVSKRVAWRYDEEK
IEFEWNTGTNVDTKKMASNFPV----DLSEYPRSLHMYADRLLDHKVPQTDMTFRHMGSK
LIVAMNSWLQKASGSLPYTQTLQDHLNSLKELNLQNMGLPDFHIPENLFLKSDGRVKYTL
NKNSLKIEIPLPFGGKSSRDLKMLETVRTPALHFKSVDFHLPSREFQVPTFTIPKLYQLQ
VPLLGVLDLSTNVYSNLYNWSASYTGGNTST-D--HFSLRARYHIKADSVVDLLSYNVQG
SGEATYDHKDTFTLSCDGSLRHKF-LDSNIKFSHVEKLGNNPVSKGL---LIFDASSSWG
PQMSASVHLDSKKEQHLFVKEVKIDGQFRVSSFYAKGTYGLSCQRDPHTGRLNGESNLRF
NSSYLQGTNQITGRYEDGTLSLISTSDLQGGIIKNTASLKYENYELTLKSDTNGKYKNFA
TSNKMDMTFSKQNALLRSEYQADYESLRFFSLLSGSLNSHGLELNADILGTDKINSGAHK
ATLRIGQDKVSTSATTNLKYSPLVLENELNAELGLSGVSMKLTTNGRFREHNAKFSLDGK
AALTELSLGSAYQAMILGVDSKNIFNFKISQEGLKLSNNMMGSYAEMKFDHTNSLNIAGL
SLDFSSKLDNVYSSDKFYKQTFNLQLQPYSLVTTLNNDLKYNALDLTNNGKLRLEPLKLH
VAGNLKGAYQNNEIKHIYTISSAALS-ASYKADT---VAKVQGVEFSHRLNTDIAGLASA
VDISTNYNSDSLHFSNVFHSVMAPFTMTIDTHTNGNGKLALWGEHTGQLYSKFLLKAEPL
AFTFSHDYKGSTSHHLMSRKSISTSLEHKVSALLTPAEQTGTWKLKTQFNNNEYSQDLDA
YNTKDKIGVELSGQALADLTLLDYPIEVPLLLSEPVNVIDALEMRDAVEKPQEFTIVAFV
KYDKNQDVHTINLPFFETLQEYFERNQRTIIVVLENMQRHLKRINIDQFVRKYRAALGKL
PQQANDYLNSFNWERQVSRAKEKLTALTKKYRITENDIQIALDDAKINFNEKLSQLQTYM
IQFDQYIKDNYDLHDLKIAIANIIDQIIEKLKSLDEHYHIRVNLVKTIHDLHVFIENIDF
NKIGSSTASWIQNVDTKYQIRIQIQEKLQHLKRHIQNIDIQHLAGKLKQHVEATDVRVLL
DQLGTTISFERINDVLEHVKHFVINLIGDFEVAEKINAFRAKVHELIEWYEVDQQIQVLM
DKLVELAHQYKLKETIQKLSNVLQQVKIKDYFEKLVGFIDDAVKQLDELSFKTFIEDVNK
FLDMLIKKLKSFDYHQFVDETNNKIRELTQRLNGEIQALELPQKAEAL-KLFLEETKATV
AVYLESLQDTKITLIIDWLQDALSSASLAHMKAKFRETLEDTRDRIYQMDIEKELQRYLS
LVGQVYSTLVTYISDWWTLAAKNLTDFAEQYSSQDWAKHVKALVEQGFTVPEIKTILGTM
PAFEVSLQALQKATFQTPDFIVPLTDLRIPSVQINFKELKDIKIPSRFSTPEFTILNTFH
IPSFTIDFVEIKVKIIRTIDQMLNSELQWPIPEVYLRDLKVEDIPLARITLPDFHLPEIA
IPEFVIPNLNLNDFQLPNLHIPEFQLPHISHPIEVPTFGKLYSILKIQSPLFTLDANADI
GNGTT-SANEAGIAASITAKGESKLEVLNFDFQANAQLSNPKI--NPLALKEFMKFSSKY
LRTEHGSEMLFFGNAIEGKSNTVASLHTEKNILELSNGVIVKINNQLTLDSNTKYFHKLN
IPKLDFSSQADLRNEIKTLLEAGHIAWTSSGKGSWKWACPRFSDEGTHESQISFTTEGPL
TSFGLSNKVNSKHLRVNQNLVYESGSLNFSKLEIQSQVDSQHVGHSVLTAKGTALFGEGK
AEFTGRHDAHLNGKVIGTLKNSLFFSAQPFEITTSTNNEGNLKVSFPLRLTGKIDFLNNY
ALFLSPSAQQASWQVSTRFNQYKYNQNFSAGNNKNIIEAHIGINGEANLDFLSIPLTIPE
MP--LPYTTITTPP-LKDFSLWEKTGLKELLKTTKQSFDLSVKAQYKKNKHRHSITNPLA
VLYEFTSQNIKSFDKHFEKARNNALDFVTKSYNDAKIKFDKYKAEKSHDELPRTFQIPGY
TVPV---VNVEVSPFTVEMSAFGYVIPKAVSMPSFTILGSDIRVPSYTLILP-SLELPVL
QVPRNL-KLSLPDFKELCTISHIFIPAMGNITFDFSFKSSVISLNTNAEVFNQSDIVAHL
LSSSSSVIDALQYKLEGTTRLTRKRGLKLATALSLS-NKFVEGSHNSTVSLTKKSMEASV
ATTAKVQIPILRINFKQELNGNTKSKPTVSSSMEFKYDFNSSMLFSTAKGAVDHKLILES
L-----TSYFSIESSTKGDVKGSVLS-RDYSGTIASEANTYLNSKSTRSSVKLQGTSKID
DIWNLEVNENFAGEATLQRIYSLWEHSMKNHLKLEGLFFTNGEHTSKATLELSPWEMSAF
VQVHANQPNSFLDIPHLGQEVALNANTKNQKIRWKNEVRVHSGSFQNHVELSNDQEEAHL
DIAGSLEGHLRFLKNIILPVYGKSLWDFLKLDVTTSIGRRQHLRVSTAFVYTKNPNGYSF
SIPVKVLADKFI--IPGLKLNDLNSVLVMPTFHVPFTDLQVPSYKLDFREIKIYKKLRTS
SFALNLPALPEVKFPEVDVLTKYSQPEDSLIPFFEITVPESQLTVSQFTLPKSVSVGSAV
LDLNAVANKIADFELPTIIMPEQAIEIPSIKFSVPAGIFIPSFRALTAHFEVDSPLYNAT
WSASLKNKADHVETVLDSTCSSTIQFLEYKLNVVGTHRIEDGMLASKTKGTFAHRDFSAE
YEEDGKYEGLREWERKVHLDIKSPAFTDLHLHYQKDKK-GVSTSAASPAIGTMGMDV---
--DFSKWNI---YYS-PQSSPDKKLTIFKTELR--FRESDEEIQIKVNWEEEAAS-GLLT
SLKDNVPKATGALYDYVNKYHWEHTGLTLREASSKLRRNLQSNAEWVYQGAIRQIDDID-
-LRFRKAASGTTGTYQEWKDKAQNLYQELL-TQEGQTSFQGLKDKVFDGLVLVTQEFHMK
VKHLIDSLIDFLNFPRFQFPGKPGTYTREELCTMFIREVGMVLSQVYLKVHNGSEILFSY
FQDLV----------ITLPFELRRHK---------LIDVISMYREWLK----VLSKEAQE
VFKDIQSLKT-TEVLRNLQDLL-QFIFQLIEDNIKQLKEMKFTYLINYIQDEINTIFNNY
IPYVFKLLKENLCLNLHKFN----EFIQNELQGASQELQQIHQYIMALREEYFDPSVVGW
TVKYYELEEKIVRLIKNLLVALKDFHSEYIVSASDFTSQLSSQVEQFLHRNIQEYLSILT
DPDGKGKEKIAELSTTAQEIIKSQAIAMKEIISDYHQ

PF12491 // ENSGT00590000083139_0_Domain_6 (4658, 4715)

QFKHKLQDFSDQLSDYYEKFIAE
SKRLIDLSIQNYHTFLIYIMELLKKLQS-TTL--MNPYVKLAPGELTIIL----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------

-----------------------------------------------MGPPRP-------
------ALLPLLLLLLLLLAASAPARDTVLENVS-PSCPKDATR

PF01347 // ENSGT00590000083139_0_Domain_0 (105, 674)

FKHLRKYVYNYEAESS
SGVPGTADSRSSTKINCK-ELEVPQLCNFIK-TSLC-TKEVYGFNPEGKALLKKAKNSEE
FTAAMSKYDL-RLAVPEGKQVLLYPEKEEPKHILNIKRGIISALLLPPDTEEAKQVL---
FLDTVYGNCSSDVTVKTRKGNVATEISIERN----LENCDHFQPISTAVSPLALIKGLTR
PLSTLIGSSQSC-HYTLDPKRKHVSEAICKEQHLFLPFSYKNKYGMTAQVTQTLKLEDTP
--KINSRFFDEG-AEAVGLAFESTKSTSPPKQ-AEAIVKTLQELQKLDVSEQNAQRANLF
HKLVTELRALSNEAVTSLLPKLIEVSS--PITLQALIQCGQPQCYTHILQWLKSEKANPL
LIDVVTYLVALIPKPSAERLQTIFNMAKEQQSRATFYALSHVINNYHK-TNPTGTQDL-L
EIADYLSEQIRNDCTGNEDHIYLILRVIGNIGRTMEQLTPKLQSSVLKCIKSRQPSLLIQ
KAAIQALRKMELRDEVREVLLQTFLDDTSPGDKRLAAYLMLMGGPSQSDINKITQLLTRE
KNEQVKNFVASHI

ENSGT00590000083139_0_Linker_0_3 (674, 709)

ANILNSEELYVQELRKLVEEALKTSQ-LPTVMDFK

PF09172 // ENSGT00590000083139_0_Domain_3 (709, 1025)

KFSRNYHLSKSI
SLPSLD-PVSGRIEGNLIFDPSNYLPKESMLKMTLSVFGFAPADLFEIGLQGKGFEPTLE
ALFGKQGFFPDSVNKALYWVDGQVPDHVSKVLVDHFGYNKEDKHEQDMVNGIMLNAEKLI
KDLKSKDFPEARAYLHILGEELGFVKLQDLQLLGRLLLSGARTLQGVPQMIK-ELVRKGS
KGDLFLHYIFMDNAFELPTGLGLQLQVSSSGVITPGIKAGVKLEVA-SIQAELVTKPSVS
VEFVTSMGIIMPDFARSGVQMNTNFFHETGLEARVALKAGQLEFIVPSPKRPVRLFSGSN
TLHL

ENSGT00590000083139_0_Linker_3_5 (1025, 1041)

VSTT----KTEVIPPL

PF06448 // ENSGT00590000083139_0_Domain_5 (1041, 1157)

VENRQSWSTCKPFFIGLNYCTTV-AYSNASSTDSSSYYPL
TGDSRFELELKPTGEVEQYSARAFYELQRDGEALVDMLKFVTQAKGVKQTEATMMFTYNR
QSKTLSSEIQIPDFDVDLGTVLRVRDESAEEEKSYKLTLDIQNKKITEVTLTGHMXXXXX
XXXXIKGIS--IPLQAEARSEILTQWSPSKLLLQMDSS--ATAYGSTVSKKVAWRYDEEK
IEFEWNTGTNVDTKKAASSFPV----DLSDYPKSLQMYASSLLDHRVPQTNMTFRHMGSK
LAVATSTWLQEASRNLPYAQNLQDHLSGLQELYLQKMELPDFHIPENLFLKSDGRIKYTL
NKNSVNIEIPLPFGGKSSKDLKMLETIRTPALNFQPVGFHLPSQEFQVPTFTIPKLYQLR
VP-LGVLDLSTNTYSNLYNWSASYTGGNTST-X--XXXXXXXXXXXXXXXXXXXXXXXXX
SAKTTYDHRNTLTFSGDGSLHHKF-LDSHVKFSHVEKTGNNPASKGF---LTFDASSAWG
PQISASVHLDSKKKQHLYVKEVTIDGQLRASSFYAKGVYGLSYQRDPTTGQLSGESNMRF
NSSYLQGTNQITGRYEDGTVSVTSTLDLQGGLMKNTASLKYENYELTLKSDTNGKYEDFA
TLNKMDLTFSKQSALLRSEYQ-DYKSLKFFTLLSGSLNSRGLELNADILGTDRINSGAHK
ATLRIAQDGMSTSATTNLKYSPLMLENELNAALGLSGASLKLTTNGRFREHHAKFSLDGR
ATLTEVSLGSAYQAMILGVDSKNIFNFRINQEGLKLSNDMMGSYAEMKLDYTNNLNIAGL
SLDFSSKLDNIYSSDKFYKQNFNLQLQPYSLVTTLNNDLKFSALDMTNNGKLRLEPLKLN
VGGTIKGAYQNNELKHIYTLSYADLS-ASYKADT---VAKVQGAEFSHRLNTNIAGLAST
VDISTNYNSDSLHFNNVFHSAVAPFTMTVDTRTNGNGKLVLWGQHTGQLYSKFLLKAEPL
AFTFSHDYRGSTSHHLVSRRSIRTALDHKISALLTLAEQTGTWKLKTQLNQNEYSQDFSA
YNTKEKVGVELSGRALADLTVLDSPITVPLLLSEPISVIDALELRDAVDQPQEFTLVASV
KYDKNQEVHTINLPFFKILPEYFEKTREVVIGALEAIQKELKHINIDERMRKYTAALDKL
PQQVNDYLNAFNWEKHVLSAKEKLTAFTENYRITENDLQIVLDNAKINLNGKLSQLQTYV
IQFDQYIKDNYDLHDFKAAIAKIIDRIIEKLKTLDERYHIRVTVLKEIRDLCFLIENIDF
NKIGSSTASWIQNMDTKYQIRIQIQEKLQQLHAQIQNVDIQHLADKVRQQVEAVDVRVLL
DQLRTTISFQRIKEIIEHVKYCVTHLFEDFVVIEEINAFRVMVHEFIETYKIDHHIQVLM
DKSVQLAHQYKLQETVQKLSSVLQQVKMADLVEELIGFTDHALRQLEALSFKQFIEEINR
FLDMLVKKLRSFDYHQFVGETNNKIREVTQRINGEIRALGLPQKAKAL-QLFTEDVKATV
SVHLENLKATKVTWFLDWLRV-----SIVHMKAKFQDTLEDIRDRVYQMDMQQEVQRYLF
LVGQVYSTLVTYISDWWNLAAKNLTDFAEQYSLQDWAKNLKTLVEQGFTVPKIQTTFGTI
PAFEVSLRALQEATYQTPDFIVPLTDLKIPSVQINFKKLKDIKIPSRFSTPEFTVLNTFH
IPSFTVDLVEIKTKIIRTIDQMLNSELQWPVPEVYLRDLSGVDTVLARIPVPDFHLPEIT
IPEFVIPHLNVTDFQVSDLHMPEFQLPHISHTTEVPTFGKLYGILKIQSPLLILDANADI
QNVTA-SANQAEIEASVTAKGESKLEVLNFDFQANAQLSDPKI--NPLVLKESMRFSSKY
LKMEHESEVLFVGNAIEGKSNTVGGLHTEKNTLELSNGVLVKINHQLTLDSNTKYFHKLN
IPKLDFSSQADLRSEIKTLLEAGHLAWTSSGTGSWKLACHKFSDEGTQESQSNFTVEGPI
TSFGLSNKINSKHLRVNQNIVYESRFLNFSKFEIQSQAECQYLGRSVLTAKGMALLREGK
AEITGNHDAHLNGKVIGTLKNSLFFSAQPHALTASTNNEGNLRVSFPLKLTGKIDFLNNY
ALFLSPGAQQASWQSSARFNQYKYNQNFSAGNNEKSIEAHIGINGEANLDFLNIPLTIPE
MT--LPYTNLTTPQ-VKDISLWEKTGLKEFLKTTXXXXXXSVKAQYKKNKDKHSIPCPLA
GFYAFINRNINSFNRHFETVRNKALDFFIKSYNEAKITFDKYKVEKSLNQQPRFYKIPGY
TIPV---TNIEVSPLTVKMLTFGYVIPKEISTPSITIPGSGAYVPSYTLVLP-FLELPTL
HVPRNLLELSLPEFKVLSTTNKILIPAMGNITYDFSFKSSVITLNTNVGLYNQSDIVAHF
LTSSSSVIDALQYKLEGTSSLTRKRGLKLATALSLS-NKLVEGNHDNTISFTKKNMDASM
TTTARVQIPLLRMNFKQELNGNTKSK-TVSSSIELKYDFSWPHVYTTATGAFDHKLSLEC
L-----TSYFSIESSTKGGVKAFILS-REYSGTLASEASTYLNSKGTRSSVKLLGASKAD
GIWNLEVKENFAGETTLQRIYAIWEQNTKNHLQLGGLFLTSGEHTSKATLELSLWEISAL
VQVRARQPNSLLNINYLGQEVSLNANTENQKMSWKSQVQVHSGSLQNNIQLSNGQEEARL
DMAGSLEGYLWFLKDAVLPVYDKSMWDLLKLDVTTTNDRKQYLRASTALVYTKNPNGYPV
SIPVQELAAKFI--IPGLKLYNLTSVHVTPTFHVPFTDLQVPSYILDFSEIKIYEKLSTL
PFALNIPTLPKVKFPKVDVLAQYSEPEVSSVPFFEITVPASQLTVSHFTLPKSISVGSAV
SDLNVVASNTADFELPTVTMPEQTTEIPSMKFSVPAGIFIPSFGTLTARFEVASPLYNAT
WSAGLKNKGDHVETFLDSTCSSTIQFLEYDLNVVGTHKIEGGMLVCKTNGSFAHRDFSAE
YEEVGRYQGLGYWNRKVDLNITSPILTDVPLRYQESEN-H-SFSVASPAIGTVVIGLKNS
NDTLLRWNL---YYR-PQSSPDKTLNIVKIEMRAP--ESDNVVQIKANWEEEAVS-ELLS
SLKDNMPKAMGASYDYVNKYHQEYTGLDLRDASLKLRRGLQNSAEQVYQGAVRQIDEVD-
-VGLRRIARGTTNTYQQWKDTAKSLYQELL-AQEDHSGFQRLQKKVFDSLIGVTQEYNVT
VNRVIDSFIDFLKSTRFQLPGRAGNYTEDELYTMVLKKVGKLLSQVHSKIHSGLEILFSY
FQDLMN----------KFPFDSVYYQ---------LIGIGSEYGKLLK----SLSQEIQK
ALSDLQSVKT-TEMLSNLKRFL-QSIFQEIEEDLKRLKEKKFTDLINDIQHDISITFDTF
ISFVFRLLKENLGPNFGEFN----ELVQNKLQEASQELQQLHQYVQALRKEYFDPSMVGW
TVKYYELEEKFINLIKKLVDVLKDFHSKYTVSAAGFASQLSSQVEQLVQKDFQEYLSILA
DADGKGKEKIAELSTSAQEIIKSWAVAVKEIISDYRQQFTYKLQDFADQLSDYYEKFIAE
SKRLINLSIQNYHMFLRYIMELLKELQL-ATVNGMSPYIKVAPGEFTITF----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------

-----------------------------------------------MGAPGP-------
------ALLLPAL--LLLLAPSARAQDEVLEDVS-PTCQ-DANR

PF01347 // ENSGT00590000083139_0_Domain_0 (105, 674)

FKPLRKYIYNYEAESS
SGVPRT-DSRSIIRINCKVELEVPQRCSFILKTSQCTLKEVNGFNPKGKPLMKKTANSEE
FAAAMSKHEL-RLAVPDGRPILLHPEPEEPDHTLNVKRGIISALLVPPEMEDAQRVL---
FLDTVYGNCSSNFSVRTRKGSVATEVSIERN----LKDCDHFRPASTGVSPLALIRGLNR
PLSTLISSSQSC-RYTLDPKKKHVSEAICKEQHRFLPFSHK--NGMMAQITQTLKLEETR
--NFNSRLFDEG-TREVGLAFESTKAASPPGQ-AEAAMKTLQELQSLHISEQNAKRANLF
SKLVSELRGLSDEAVSALLPKLFGVSX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXX-X
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXVREVLLQTFLDDASPGDKRLAAYLMLMRDPSQSDVSKITQLLPWE
QNAQVKNFVASHI

ENSGT00590000083139_0_Linker_0_3 (674, 709)

ANILNSEELYVQNLKMLVKEALKNSQ-LPTVMDFK

PF09172 // ENSGT00590000083139_0_Domain_3 (709, 1025)

RFSRNYHFSKSL
SLPLLD-PVSAKIEGNLIFDPHNYLPKESMLKTTLTVFGLASADIFELGVEGKGFEPTLE
AFFGKQGFFPDSVNKALYWVDGQVPDHVSKVLVDHFGYTKDDKREQDMVSGIMLTVEKLL
KDLKSKEFPEARAYLRILGEELGFVSPL-QQVLGRLLVNGARILXXXXXXIG-EVIKKGS
KSDLFLHYIFMDNAFELPTGLGLQLQMSSTGVIAPGIHAGVKMEVA-KMQAELVTKPSVS
VEFVTHMSVVIPDFARSGIQMNTNFFHETGLEARLSLMAGQLKLSIPAPNRPIKLFSGSN
TLHL

ENSGT00590000083139_0_Linker_3_5 (1025, 1041)

VSTT----KTEAISSL

PF06448 // ENSGT00590000083139_0_Domain_5 (1041, 1157)

PENRKSWSICKPFFTGLNYCMG--AYSNASSTGTSSYYLL
AGDTRFELELKPTGEVEQYSASATYELQREGEAFVDMLKFVTQAEGVRETEATMTFRYNR
QSMTLSSEMQIPDFDVDVGTVLRVSDESAKEKKSYKLTLDIQNKKITEVTLTGHISGYGK
EEGRIKGVISIPRLQAEARSEILTQWSPTKLLLQMDSS--ATAYGSTISKKVAWRYDEDK
IEFEWNAGTNVDTKKIISNFPT----ALSDYPKTLCALGNSILDHRVPQANMTFRHMGSN
LIVATNTWLQKASMSLPYAQILQDYLWGQKELKLRKISLPGFYIPENLFLKSDGRVKYTL
NKQSVKFEIPLPFGGKSSKDLKILQAIRTPALNFKSVGFYLPSREFQVPAFTIPELYHLQ
VPLLRMLDVSTNIYSNSYNWSASFSGGNVST-D--HLRLKASYHMKANSVVELLSYRTQG
SAETTYDPRKTFTLSYDGVLRHRFFLDSNIKFSHVESIGNNPASKGF---LTFDASNAWG
PEMSASVYWDSKKKEHLYIKEAKIDGQFRVSSFYANGAYGLSYRKDSTTGQLSGKSNLKF
NSTYLQGTNQITGTYEDGTVSLTSTSDLQGGILKNTASLKYENYELILKSDTNGKYEDFA
TSNKVDLTFSDQNALLRSEYQTDYKSFRFFALLSGSLNSHGLELNADVLGTDRINSGAHK
ATLRIGQDGMSTSATTNLKYSPLVLENELNAALGLSGASVKLTTNGRFREHNAKFSLDGK
AALTEASLGSAYQATILGVNSKNIFNFKINQEGLKLANNMMGSYAEMKLDYTNNLNVAGL
ALDFSSKLDNIYSSDKFYKQTFNLQLEPYSFVATLNNDLKFSALDLTNNGKLRLEPLKLN
MGGNVKGAYQNNEIKHIYTISYADLS-ASYKADT---VAKAQGTEFSHRLNMNIAGLASA
IDVSTNYNSDSLHLSNVFRSAVAPFTMTIDAHTNGNGKLVLWGEHTGQLYSKFLLKAEPL
ALTFSHDYKGSTSHHPVSRRSISTALDHKVGILLTPAEQTSTWKFRTQLNENEYSHDFDG
YNTKDKVGMELNGRALADLTILDFPIKVPLLLSEPVNVISALEMRDTVDQPQEFTIVASV
KYDKNQDVHTINLPFLKILSEYFEKNQLVIISALETIQRGLKRIDIDQFVRKYGVALDKL
SQQVNDYLNEFSWERQVSNAKEKLTAFTKNYTITENDLKIVLDNAKINLKLS----LTYV
IQFDHYIKEYYDLHDFSAA--KII-ARIEKLKILDEQYH-RVNLVKIIHDLYI-IEKIDF
NKIGSSIASWIQNVDTKYQIRIQVQEKLQHLKTQIENIDIQHLAEKLKQQVEAIDVRVLL
DQMRTTIPFQKIKEIIEHVKYYVRDLIDDFEVTEKIIAFRAIFYKLIKMYEIDQHIQVLM
DKSVQLAHQYKLKETVQKLSNALQQVGIKDHFEKLAGFINDALNQLKALSFKNFIEEVNR
FLDMLVKKLRSFDYLRFVDETNNKISEVTQRIHGTIQDLDLPQKAKAL-KLFVEDVKAMV
SVYLENLKGTNITLFIDWLQEDLSSMSLIYMKDKFQETLEDIRDQIYQMDLQQEVQRYQC
LVSAAYSTLVAYISDLWSLAAKNFTDLAEQYAIRHWAENLKALVEQGFTVPEIQTAFGIV
PAFEVSLRALQEATYQTPDFIVPLTDLKIPSVQINFKKLENIKIPLRFSTPAFTVLNTFH
VPSFTVDLVEIKAKIIRTIDQILNGELQWPVPEVNLRDLKGTDTIFARITLPDIQVQEIT
IPEFVIPNLNLKDFQVPDLHIPEFQLPSISHTIEIPALGKLHSILKIQSPFFILDMNADI
QNVTT-SVNKAEITASITAKGDSKLEVLKFDFQGNVQLPDPKI--NPWSLKEFMSFSSKY
LKIECKSEVLSLGNAGEGRSSIVVGLHTGKNTVELSNAVLVEINHQLTVDSNTKYFHKLN
IPKLDFSSQADLHNEITALVRDGHKAWTSSGRGSWKWACPSLSDEGTHELQVSFTEEGPN
ASFGISNKIHSKHLRVNQTLVYDSDF-DFCKLEIQSQVESQHVGQSVLSAKGTALLRERK
VEMAGNHDAHLKGKVSGTLKNSLFFSAQPFEITTSTSNEGNLKVSFPLKLTGKVDFLNNY
ALFLSPDAQQASWLASARFNQYKYNQNFSAGNNENSIQAHIGINGEANLDFLNIHLTIPE
TT--LPYTGLTIPQ-VNYFSLWEKTGLKELLKTTKQSFDLSVKAQYKRNKDKHSISIPLD
AFDEFI----VSFNRHFEKVRDKALSFFAQSYNEAKLMFDEYKVEKSLSNQPRTYRIPGY
TIPV---VNIEVLPXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXX-X-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXS-NKFVEGNHDSTISLTKKNMDASV
TTTAKVQIPILRMDFKQELNGNTKSKPTVSSSIELKYNFNSTKLSSTATGTAGHKLSLES
L-----TSYFSIESSNKGDIKGAVLL-QEYSGTIASEVSTYLNSKGARSSVKLQGTSRVD
GIWNLEVEESFAGEATLRRIYAMWEHNTKNHLQLKGHSLTSGEHASKATLELSPWKMSAL
VQVRASQPNSLLDVNHLGQEVSLNADSENQRVSWKSEIQVYSGSLQNDIQLSNNQERARL
DVTGSLEGPLWLLKNTVLPVYDKSIWDLLKLDVTTSTERKQYLSVSSALVYTKNPHSYTF
SVPVQELADKFI--IPGLKLNNPNSVLVTPTLQVPFTNLQVPSYTFNFSEIKIYKKLRTS
PFALNVPALPKVKFPEVDVLTTYSKPEGSSVPFFEITVPGSQLTMSQFTFPKSISVGTAA
VDLNEVAHKTADFRSPNVTQPERTMEIPSMQFSVPAGISIPSFGALTAQFGVASPLYNAT
WSAGLKNKVDHIETSLESTCSSTMQFLEYDLNVVGTHKIKDGVLVSKTKGTLEHRDVSAE
YKEDGKYRTLQDWEEEVHLDITSPTFTSVQLHYHIGEN-NYSFSAASPAIGTVALDSEND
N-DILKWNY---YYH-PQLSPNKKLNIFKLELR--YQEANDKFQVKVNGEEEAMSLSLLN
SLRDNVPKVTGALYDYVNKYHEEYTGLDLKDASLKVRGRLQNSTEQAYQKAVRQIDEVN-
-TTLGRVVRDATGTSQLWNDKAQNLYQELL-DQEG-VSLQRLQNKALDSLTGVTEEYKIV
VSHLIGKFIDYLKFPRF-LRGRAGTYTIDELCTGVMREVGKVLSQVYK-ICSRLEMLFCY
FQDLM----------SKFPFDLRSHK----------VDITLKFGKLLK----SLSQKVQK
VFNYLQSNKTTTEMLGDFQRYL--NIFQEMEN--EWLKEKKFINLINDIQHKIN-TFTSY
SQHVFRCLKENLYLEFGTFN----ELVNKLQKASHVEI----HQVKSLHKECFYPGVVSW
TVKYYELEEKIINLIKNLVHVLKDL----------FASQISSEPEQLMQKDIQKYFSILD
NTDGKRKENTVELSNSAQEIIKSWAIAMEEIISDYRQHFEYKLQDLSNHLSDYYEKFIAE
SKRLIDLSIQKYT-FLRYITELLKELLQSATANDM-SLYKIASEEFTITF----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------

------------------------------------------------------------
-------------------------EEEVPENGS-PSCPKDGTR

PF01347 // ENSGT00590000083139_0_Domain_0 (105, 365)

FKHLRKYVYNYEAESS
TGVAGDSFSRSATRINCKVELDVPQLCSFILRTSQCTLKEGYSFNPNGRPSLHKSKNSEE
FAAAMSKYEL-RLAIPEGKQVSLYPDKEEPKHILNIKRGIISALLVPPETEEDKQVV---
FLDTVYGNCSSDLTVETKKANVATRISIERD----LENCDHFKPISTGVSPLALIKGMLH
PFSTLISSNQSC-QYTLDPKNKHVSEAICKEQHVLLPFSTKDKHAMMAKVTQTLKLEDTP
--KINSRFFDEG------------------------------------------------
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-----------------------------------------------MGPQRPPLP----
------LVL---LLLLLLLDTSVWAQDEVLENVN-WNCPN-ATR

PF01347 // ENSGT00590000083139_0_Domain_0 (105, 385)

FKHLRKYVYNYEAESS
SGVRGTADSRSTTKINCKIELEVPQLCSFILRTSQCTLKEVYGFNPEGKALMKKTKNSEE
FAAAMSRYEL-KLAIPEGKQAVLYPEKDEPKHILNIKRGIISALLVPPETEEAKQVL---
FLDTVYGNCSTQVTVTTRKGNVATEMSTERD----LQQCDGFQPISTSVSPLALIKGLVR
PLSTLISSSQSC-QYTLDPKRKHVSEAMCKEEHLFLPFSYKNKYGIMTHVTQTLTLEDTP
--KINSRVFSEG-TEQVGLAFESTKSTSPPKQ-AEAVLKTLQ------------------
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------------------------EEALERENVI-SSCPKDATR

PF01347 // ENSGT00590000083139_0_Domain_0 (105, 674)

FKHLRKYVYTYEAESS
SGVPGTADSRSATKITCKVELEVPQLCSFVLKTSQCTLKEVYGISPEGKALLKKTKNSEE
FSTAMSXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX---
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX----XXXXXXXXXXXXXXXXXXXXXXXTR
PLSTLVSSSQSC-QYTLDAKKKHVSEAICKEQHLFLPFSYKNKYGMMARVTQSLKLEDTP
--KINTRFFDEG-VEAVGLALESTKSTSPPKQ-TEAIVKTLQELQHLSVSEQNAQRAKLF
HKLVTELRGLRNEAVASLLPKLIEVSS--PVTLQALVQCGQPQCYTHILQWLRTEKANPL
LIDVVTYLMALIPEPSAERVREIFITAKEQQSRATLYALSHVVNXXXX-XXXXXXXXXXX
XXXXXXXXXXXXNCTGDTDHVYL-LKVIGNMGKTIDQVSPSLKSAVLKCVRSTEPSLLIQ
RAAIQSLRKMATNDEVQRALLQAFLSGVAPVDKRLAAYLMLMKGPSQSDISRIARLLPRE
QNEHVKNFVATHIANILNSEDLSIQHLKMLVEEALKGSQ-LPTIADFRKYSRNYQLSKSV
SLPSLG-PVSTKIEGNLIFDPNSYLPKESMLKTTLTVFGFSALDLFEIGVEGKGFEPTLE
ALFGKQGFFPDSVNKALY-VDGHVPDQVSKVLVDHFGYTRNNRHEQDMVNGIMFNIEKLI
KDLKSKDIPEASAYLRFLGEELGFVRLSDLQHLGRLLLSGVQNLQGIPQLIK-EAIRKGS
MNDLFLHYIFMDNAFELPTGAGLQLQVSSSGIIAPGTKAGVKVEVA-NMQADLVAKPSVS
VEFVTNMGIIIPDFAKSGVQMNTNFFHESGLEARVALKAGQLKFIVPTPKRPVKLFSGSN
TLHLTSTT----KTEAVLPL

PF06448 // ENSGT00590000083139_0_Domain_4 (1041, 1084)

AVDRQSWTTCKPFFTGLNYCTTG-AYSNASSTDDSSYYPL
TGDTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXX----XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXATNTWLQKTSRNLPYTQILQDHLSGLEEMNLQKMGLPDFHLPENLFLKXXXXXXXXX
XXXXXXXXXXXXXXGRSPKNLNILETVRTPALHFKSVGFQLPSQEYRIPTFVIPKVYLLR
VPLLGVLDLSTNVYSNAYNWSASFTGGNTST-D--HFGLKAQYLMRAMSAVDLFSYSVQG
SGETTYDHRNTFTLSCDGSLRHKF-LDSNIKFNHVEKSGKNPASKGL---LTFDATSAWG
PQLSASVHLDTKKKQHLNVKEVKVEGQFRVSSFYTKGIWGLAYQRDLNTGELHGESNLRF
NSSYIQGTSQMTGRYEDGALTFTSNSDLQDGLLKNTVSLKYENYELTVKSDTNGRYRDFA
TSSKVDVTVSRQNALFRSEYQANYNALRFYSVLSGSLDSHGLELNADVLGSDTLNSGAHK
ATLRVDRGGLSTSATTNLKYSPLVLENELNAGVGFSGATLKLTANGRFREHHAKLILDGK
AGLTEISLGSAYQAMILGVDSKNIFNFKINQEGLKLSSDMMGSYAEMKLDYTNSLTMADL
SLDFASKLDNVYSSDKFYKQNFHLKLQPYALVTTLNNDLKVNALQLTNNGKLQLEPLKLN
MGGTIKGAYENNEIKHIYAMSYADLS-ATYKADT---VAKVRDAEFSHRLSTDIAGLASA
IDISTNYNSDSLHFSNVFHSTMEPFTMTIDAHTNANGKLALWGEHTGQLYSKLLWKAKPL
ALTFSHDYKGSTSHHLMTKRSIETALEHQVNALLTPAEQMGTWKLKTQLNKHEYSQDFDA
YNTKDKVGVELSGRALADLTVLDWPINVPFILTEPVNVFDALEMRDVADQPQEFTIVASV
KYDKNQDVHTIDLPFLQILPEYFEKNRIAIITALERIQRHLKHININQISRKYKASLDQV
PQQVNDYLKAFNWEAQVTNAKEKLTAFTKDYRITANDLQIALDNAKINLNEKLSQLQTYV
IQFDQYIKDNYDLHDLKLAIAKIIDLIIERLKVLDENYRIRVNLIKTIHDLHVLVEKIDF
NKMGSSTEAWIQNMDTKYQIRIQLQEKLQQLRTQIQNIDIQHLAEKLKHQVETIDIRVLL
DHLRTAIPIQSLKDIIEHVRHFVVNLIEDLEVTEVINAFRAQVHDLIKKYEVDQQIQVLM
DKSVQLAHQYKLKETLQRLSSALKRVEIKAYFEKLVGCIDDVVKKLKALHFENFMGEVNR
FLDMLVEKLRSFDYNQFVDETNNKIREMTQRINSEILAVELPQKVEAL-KVFVEEVKAVM
SVYWAALKDTKITVFLDWLQEAFSSTSLRYMKARFQETLEDTRDRVYQMDIQQELQRYLS
LISQAYKTLVMYVSDWWILAEKALTDFAEQYSIQDWAESIKGLVEQGFTVPEIRTVFWAM
PSFEVSLRALKGATFQTPDFIVPMTDLRIPSVEINFKTLKDIKVPSKFTTPEFTVLNTFH
VPSFTIDLIEIKAKLIRTIDQMLSSELQWPVPEIYLRDLKVNDTLLAGITLPDFYLPQFT
IPEIIIPKINVKDFEVPNLHIPEFQLPHISHTIQIPTFGKLYGILKIQSSLFTLDANAAI
QNITT-SVNKAEMVATFTAKGESKLEVLNFDFQANAQLSDSEL--NSIIVKESMKLSNKY
LKTEHSSQVVFSGNAIEGKSDTLASLHTEKNTMELSNSMLLNINQQFALESNTKYTHKLS
IPQLDFSSQADLRNGMKTLWEAGRIGWTSSGTGSWKWACPKFSDEGTHESQINFTVEGPT
ASFGLSNKINSKHLRVNQKLLGESGFLNYLKFEIESQVDSQHVGRSILTAKGAALLGEMK
AEITGTHDASLNGKVIGTLKNSLVFSAQPFEIMASTNNEGNLKVSFPFKLTGKIDFLNNY
ALLLNPSVQQASWQASARFNQYKYHQNFSAGNNENSMEAHVGMNGEANLDFLNIPLTIPE
MT--LPYMTLTTPQ-VKDFSLWERTGLKDFLKTTKQSFDLSVKAQYKKNKGRHSIPVPLD
VFYDFINQHIKSFNKYLEKVRDSAV-----------------------------------
------------------------------------------------------------
YIPWSLRKLSLPDFQLPQTSNNIFVPALGNMTYEFSFKSSVITLNTNVGLYNQSDIVAHL
LSSSSSFITALQYKLEGTSSLTRKRGLKLATAWSLS-NKFVEGSHDSTMSLTRKNMEASM
ATSANVQFPILRMNFKQELNGNTKAKPTLSAAIELKYDFNCPRLYSAAKGAVDHKFNFEG
L-----SSYLSMESSTKGNVKGSVLS-REYSGNLASEVNTYLNSKGTRSSVILRGASRLD
GIWNLEVKENFAGEATLSRIYAIWEHSTKNLLQLQGTFVTSGEHTSKATLELSPWKMAAL
VQVRASQPNSLLDIPYFGQEGVLNADTENQKVSWKSEVQVHTGSLQSNFQLSNGQKEARL
DIAGSLEGHLSFLKEVVLPIYDKSVWDLLKLDVTTSSGRRQSLHAATALVYTKNPNGYYF
SIPVKELADEFI--IPGLKLNDPNSILVTPTWRVPLTNLQIPSYTLDFSEIKISKKLSTS
PFDLNIPTLPKVKFPQIDVLTKYSEPEESSVPFFEVTVPGSQLIVSPFTLSKSISVGSAT
LDLNKIANKIADFDLPTITVPEQMIAVPSMTFSVPAGIFIPSLGSLSARFAVTSPLYNST
WSAGWKNKADHFETFLDTTCSSTLQFLEYDLNIVGTHKFEDGALVCKTQGTFSHRDLSAE
YKEDGKYQTLADWLGEARLDITSPKFTDIHLHYQSDEK-SLFSSIASSAIGSVVLNLEEE
DEDAFKLEF---YYL-PQSSPGKKFNILTTEWK--YQESDNEMQIKVNWEEEATS-QLLS
SLKDNVPKATGALYDYINVYHREHTGVDLRDVASRLRRSIENGAELAYLGALRQINKAD-
-IGLRRAAGSTARAYKQWKDEAQNLYQDYF---------QNLSDRVYDSSIQVIQTYNTT
ITHLIDSLIEFLRAIRFQLPGKARTYTGAELCTMVTSEVGKVLFQGNLIVQSGLNVLIAY
VHELG----------IILPFHYGTYS---------LTDEFVGAGKLLH----ALLEEIQK
EFNRLQSKTS-TELLTDLKALQ-QEILQEVEKKVLKLKRNKLSDVVSTIQDMISMTFNKL
IPYIFTCLKEHLY----NFK----ELAQNKIQEVSQKLKELHEYIKTLREEYFDPSMVGW
TVKYYELEEKVTNIVTTLIIILQDLHSTYTVTSAYFISELSSQYEQFMSENVQEYLIILA
DGHGKGTEKITELCTIAQDIIKRWATAMKEIISGYYQQFPLKLQNFADQLSDYYEEFLTE
SKRLIDLSIQKYHMFLSYLTELLNKLQS-DIANDLSPYFKVVPGEIIITF----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------

------------------------------------------------------------
MGLPRPALLALPALLLLLLQAGAGAEEEVLENVT-PICSRDATR

PF01347 // ENSGT00590000083139_0_Domain_0 (105, 673)

FRHLRKYVYSYEAESS
SGVPGTADSRSVTRINCKAELEVPQPCSFILKTSQCTLKEVYGFNPEGKALLKKTKNSEE
FAAAMSRYEL-KVAIPEGKQVFLYPEKDEPTHILNIKRGIISALLVPSETEEAKQVL---
FLDTVYGNCSTDFTVKTRKGNVATEISTERD----LGRCDRFKPISTVTSPLALIKGITR
PLSTLISSSQSC-QYTLDAKRKHVAEAICKEQHLFLPFSYKNKYGMMTQVTQTLKLEDMP
--KINSRFFGEG-TNKMGLAFESTKSTSPPKQ-AEAVMKTLQELKKLTVSEQNSQRANLF
NMLVTELRGLSDEAVTSLLPQLIEVSS--PITLQALVQCGRPQCYTHILRWLSSVHANPL
LIDVVTYLVALIPEPSVQQLREIFNTAREQRSRATLYALSHVVNNYHM-TNPTGTQEL-L
DVANYLMEQIQDDCTGDEDYTYLILRVIGNMGQTMEQITPELKSSILKCVQSTKPSLMIQ
KAAIQALRKMGLEDKDQEVLLQTFLDGASPGDKRLAAYLMLMRDPSQADINKIVQLLPRE
QNEQVKNYVASH

ENSGT00590000083139_0_Linker_0_3 (673, 709)

IANILNSEELYIQDLKKLVKEALKESQ-LPTVMDFR

PF09172 // ENSGT00590000083139_0_Domain_3 (709, 1017)

KFSRNYQLSKSV
SLPSLD-PASAKIEGNLIFDPNNYLPKESMLKTTLTVFGFAPADLFEIGLEGKGFEPTLE
ALFGKQGFFPDSVNKALYWVKGQVPDGVSKVLVDHFGYTKDDKREQDMVKGMMLSVEKLI
KDLKSKEAPEARAYLRILGEELGFARLHDLQLLGKLLLMGARTLQGIPQVIG-EIIREGS
KNDFFLHYVFADYAFELPTGAGLQFRMSSTGVIAPGAKAGMKLEVA-KMEAELVAKPSVS
VEFVTNMGTIIPNFARSGVQMHTSIFHESGLEARVALKAGQLKFIIPSPKRPVKLF

ENSGT00590000083139_0_Linker_3_5 (1017, 1044)

SGGN
ILYLVSTT----KTEEIPPLIEN

PF06448 // ENSGT00590000083139_0_Domain_5 (1044, 1155)

RQSWSTCKPFFTGLNYCTSG-AYSNASSTDSASYYPL
TGNTRLELELRPTGEIEQYSVSATYELQREDRALVDTLKFVTQAEGVKQTEATMTFKYNR
QSMTLSSEVQIPDF

ENSGT00590000083139_0_Linker_5_6 (1155, 4658)

YVDLGTILRVHDESTKGKKSYRLTLDIQNKKITEAALMGHLSCDTK
EEGKIKGVISIPRLQAEARSEILTHWSPAKLLLQMDSS--ATAYGSTVSKRLAWHYDEEK
IEFEWNTGTNVDTKKMASNFPD-----ISDYLWSLAFGVIGILDTRIPPTDMTLWHMGSK
LVVTTHSWLQQASESLPYAQTLQDHLSGL-ELNLQNMEWPDFDIPENLFLKSDGRVKYTL
NKNSLKIEIPLPFGGKSSRDLKMLETIRTPALQFKSVGFHLPSQEFQVPTFTIPELYQLQ
VPLLGVLDLSTNVYSNVYNWSASYTGGNTST-D--HFSLRASYHMKADSVVDLLSYNVQG
SGETTYDHKNTLTLSCDGSLRHKF-LNSNIKFSHVEKVGNNPVSKGL---LTFDASSAWG
PQMSASVHLDSKKKQHLFVKEVKIDGQFRVSSFYAKGTYGLSCQRDPHTGRLNGESNLRF
NSTYLQGTNQITGRYEDGTLSLTSTSDLQSGIIKNTASLKYENYELTLKSDTNGKYKNFA
TSNKMDMTFSKQNALLRSEYQANYESLRFFSLLSGSLNSHGLELNADILGTDKINSGAHK
ATLRIAQDGVSTSAMTSLKYSPLVLENELNAELGLSGASVKLTANGRFREHHAKFSLDGK
AALTELSLGSAYQAMILGVDSKNLFNFKISQEGLKLSNDMMGSYNEMKLDHTNSLNIAGL
SLDFSSKLDNIYGSDKFYKQTFNLQLQPYSLVTTINNDLKYNALDVTNNGKLRLEPLKLN
VAGNLKGAYGNNEIKHIYTIAYAALS-ASYKADT---VAKVQGVEFSHRLNTDIAGLASA
VDISTNYNSDSLHFSNVFHSVMAPFTVTIDAHTNGNGKLALWGEHTGQLYSKFLLKAEPL
AFTFSHDYKGSTSHHLMSRKSISTTLEHKASALLTPAEQMGTWKLKTQFNNNEYSQDLEA
YNTKDKIGVELSGRALADLTLLDSPIKVPFLLSEPVNVIDALEMKDAIETPQEFTIVAFV
KYDKNKDVHAISLPFLETLQEYFERNQQTVIIILEHMQRDLKHININQFVRKYRAALGKL
PQQVDNYLNSFNWERLVSHAKEKLTALTNKYRITENDIQIALDDAKINFNEKLSQLQTYV
IQFDQYIKDNYDLHDLKIAIANIIDRIIEKLRSLDEDFHIRVNLVKTIHDLHLFIENIDF
NKTGSSAASWIQNVDTKYQIRIQIQEKLQQVKRHIQNTDMQHLAGKLKQYVEATDVRVLL
DQLGTTISFERINDILEYVKYFVINLIGDFEVAEKINAFRTKVHELIERYEIDQQIQVLM
DKSVELAHQFKLKETTQKLSNVLQQVKIKDYFEKLIGLIDDAVKQLDELSFKTFIEDVNK
FLDMLIKKLRSFDYHQFVNETNNKIHEVTQRLNGEIQALELPQKAKAL-KLFLEDTKATV
AVYLESLQDTKITLIIDWLQDALSSASFAHMRAKFRETLEDTRDRMYQMDIQQELQRYLS
LVGQVYSTLVTYISDWWTLAAKNLTDFAEQYSIQDWAERVKALVERGFTVPEIKTILGTV
PAFEVSLQALQKATFQTPDFIVPLTDLRIPSVQINFKELKVIKIPSRFSTPEFTLFNTFH
IPSFTIDFVEIKVKIIRTIDQMLNSDLQWPVPESYLRDLKVEDIPLARITLPDFPLPEIA
IPEFVIPNLNLSDFQVPDLHIPEFQLPHISHTIEVPTFGKLYGILKIQSPLFTLDANADI
QNETT-SVNKAGIAASITAKGESRLEVLSFDFQAKAQLSTPKI--NPLALKESVKFSSKY
LRTEHDSEMLFFGNAIEGKSNTVASLHTEKNTLELSNGAIVKINNQLTLDSNTKYFHNLN
IPKLDFSSQADLRNEVKTLLEAGHVAWTSSGKGSWKWACPHFSDEGTHESQISFTMEGPL
TSFELSNKINSKHLTVNQNLVYESGFLNFSKLEIQSRAESQHVGRSVLTAKGTALFGEGK
AELTGRHDAHLNGKVIGTLKNSLFFSAQPFEITVSTNNEGNLKVSFPIRVTGKIDFLNNY
ALFLSPSAQQAGWQVSARFNQYKYSQNFSAENNENNMEAHVGINGEANLDFLNFPLTIPE
ML--LPYTAITTSP-QKNFSLWEKTGLKELLKTTKQSFDLSIKAQYKKNKHKHSIANPLA
VLCEFISQNIKSFDRHLEKARNNALDFVTESYKEAKINFDKYKAENSH-ELPRTFQIPGY
TVPV---VNVEVSPFTVEMSAFGYVIPKAVSMPSFTISGSDIRVPSYTLTLP-PLELPVL
HVPRHL-KLSLPDFKELCTISHIFIPAMGNITYDFSFKSSVITLNTNVELFNQSDIVAHL
LSSSSSVFDALQYKLEGTTRLTRKRGLKLATALSLS-NRFVEGSHNSTVSLTKKNMEASV
VTTAKVQIPILRMNFKQELNGNTKSKPTVSSSMEFKYDFNSPMLYSTAKGAVDHKLSLES
H-----TSYFSIESSTKGDVKGSVFT-REYSGTIASEASTYLNSKSTRSSVKLQGTSKID
DIWNLEVKENFAGEATLQRIYSLWEHSTKNHLQLEGLFFTNGQHTSKATLELSPWEMSAL
VQVQASQPNSFLDIPYLGQEVALNANTKNQKIRWKSEARVHSGSLHSHVELSNDQEKAHL
DIAGSLEGHLRFLKNIILPVYDKSLWDFLKLDVTTSMGRRQHLRLSTALVYTKNPNGYSF
SIPVKVLADEFI--IPGLKLNDLNLVLVMPAFYVPFTDLQVPSYKLDFREIKMYKKLRTS
SFALSLPTLPKVKFPEVDVLTKYSQPEDSLVPFFEITVPESQLTVSQFTLPKSVSVGGAV
LDLNKVAKKIADFELPTITMPEQTIEIPSVKFSVPAGVFIPSFGALTARFGVASPLYNAT
WSASLKNKADHLETALDSTCSSTIQFLEYDLNVVETLEIKNGSLTCKTKGTFAHRDFSAE
YEEDGKYEGLKDWEGKARLDIKSPAFTDLHLHYQEDEK-GLSISAASPAIGTMGMDIDED
D-DFFKWNF---YYS-PQSSPDKKLTIFKTELR--YQESDEELQIKVNWEEEAAS-GLLT
SLKDNVPKATQALYDYVNKYHWEHTGLTLRGASSKMRRNLRNKAEWVYQGAIRQIDDMD-
-MWFQKAATGTTGNYQKWMDKAQNLYQELL-TPEAQASLQGFKDKVFDSLIRVTQEFRMK
IKHLIDSLIDFLTFPRFQFPGKPGTYTRDELCTMVIREVGMVLSQVYAKVHNGSEILFSY
FQDLV----------IKLPFELRSQK---------LIDIILRCRELLN----DLSEEAQT
VFKNMQSLKT-TEVLHDLQQLL-QFIFQI-EEDIKRLKEIKLTQLTNHIRDDINTIFNDY
IPFFFKILKEILCHNLHTFN----EFIQNNLQEASQELQQIHQYIMALREEYFDPSVVGW
TVKYYELEEKIVSLIKNLLVALKDFHSEYTASASGFASQLSTQVEQFLHGNIQEYLSILT
DAEGKGKEKIEELSTTAQKIIKSWAIAMKAIISDYHQ

PF12491 // ENSGT00590000083139_0_Domain_6 (4658, 4716)

QFRYKLQDFSDQLSDYSEKFIAE
SKRWIDLSIENYHTFLRYITELLKKLQS-TTV--MNPFMKFAPGELTIIL----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------

-----------------------------------------------MGPPRP-------
------ALRLLLLLLPLLE-AGA-------QARE-YGYFSCATR

PF01347 // ENSGT00590000083139_0_Domain_0 (105, 673)

FKHLRKYMYNYEAESS
SGVPGTADSRSATKISCKVELEVPQLCSFILKTSQCTLKEVYGFNPEGKALLKKTKNSEE
FSDAMSKYEL-RLAISEGKQVFLYPEAEEPTHILNIKRGIVSALLVPPETEEDTQVL---
FLDTVYGNCSTQVTVKTRKGNVATEMSTERN----LQQCSGFQPVSIGASPLALVRGLVR
PLSTLISSSQSC-QYSLDSKRKHVSEAICKEQHLFLPFSYKNKYGMMTQVTQTLKLEDTP
--KINSRFFGEG-SQKVGLAFENTKSMSLPKQ-AEAVLKTLQELKKLSVSEQNAQRANLF
SKLVTNLRGLSSEAVTSLLPQLIEVSS--PITLQALVQCGQPQCYTHVLQWLKSEKANPL
LIDVVTYLVALIPDPSVQRLREIFNIAREQQSRATLYALSHVVNNYFE-TAHTMTEDL-Q
DIANYLQEQIRNECSGDEDHTYLILRVIGNMGRTLESITPMIKSVVLECIRSPKPSVLIQ
KAAIQALRKMELGDEVQQLLLETFVDSTSPVEKRLAAYLMLMRTPSQPDISKIIQLLPQE
ENEQVKNFVASH

ENSGT00590000083139_0_Linker_0_3 (673, 709)

IANILNSEELYIGDLKALVKEALKDSQ-LPTIMDFR

PF09172 // ENSGT00590000083139_0_Domain_3 (709, 1017)

KFSRNYHFSKSI
SLPSLD-PVSAKIEGNLIFDSNNYLPKETMLKTTLTVFGFAAADLFEIGLEGKGFEPTLE
ALFGKQGFFPDSVSKALYWVNGQVPEQVSKVLVDHFGYTKDDKHEQDMVNGIMPIVNKLI
KDLKSRDIPEARAYLRILGRELGFLKLQDLQLLGRLLLSGARTLQGIPQMV--KAIREGS
KNDLFLHYIFMDNTFELPTGMGLQLQVSSSGVITPGTKAGVKLEMA-NMQADLVMKPSVS
VEFVTNMGIIMPDFARSGVQMNTNFFHELGLEARVALKAGELRFIIPSPKRPIKLF

ENSGT00590000083139_0_Linker_3_5 (1017, 1044)

SGSN
TLHLVSTT----KTEVIPPLIEN

PF06448 // ENSGT00590000083139_0_Domain_5 (1044, 1156)

RQSWSTCRPFITGLNYCTTG-AYSNASSTESASYYPL
TGDTRYEMELKPTGEVEQYSASATYELQREDEALVDRLKFAIQAEGVKETEATLMFKYNR
RSRTLTSEMQIPDFD

ENSGT00590000083139_0_Linker_5_6 (1156, 4658)

VNLGTVLRVSDESSDGKKSYKLNLDLQNKRITEVALIGHISHDTK
GEGKIKGVISIPHLQAEARSEILTHWFPNKLLLQMDSS--ATAYGSTVSKRVAWRYDDEK
IEFEWNTGTNVDTKKVASNFPV----SLSGSLRNLHVHANSLLDHRIPQIDMTVSEMGSK
LIVAINTWFQEASNSLPYAQTLQDHLSGLKELDLQTMRLPSFHMPENLFLKSDGRLKYVL
NKNSIEFEIPLPFGGKSSKDLKMLETIRTPPLNFKYVGFHLPSQEYQVPTFTIPKLYQLR
VPLLGVLDLSTNVYSNLYNWSASYTGGNTSR-D--HFSLQARYHIKADSAVNLLSYSIQG
SGETTYDHRNTFTLSCDGSLRHKL-LDSNIKLSHVEKVGNNPASKGV---LTFDVSSTWG
PQMSASVHVDSKKKEHLYIKDVKIDGQFRASSFYSKGIYSLMFQRDSTTGQLSGESNLRF
NSSYLQGTNQITGIYEDGTLSLTSTSDLQDGTLKNTASLKYENYELTLKSDTNGKYENFA
TSNKVDLTFSKQNALLRSEYQADYKSLRFFSLLAGSLNSRGVELNADILATDKMNTGAHK
ATLRITHDGISTSATTNLKYSPLFLENELNAELGLSGASMKLAANGRFREHSTKFTLDGK
AALTEVSLGSAYQAMIMGMDSKNIFNFKVSGEGLKLSNDLMGSYGEMTLDHSNSLNIAGL
SLEFSSKLDNIYSADKFYKQNFNFQLQPLSLVTTLNNDLKYSTLDLTSSGKLRLEPLKLN
VGGNLKGAYQNNEIKHIYTISYAGLS-ASYKADT---LARIQGTELSHRLNTVIAGLAAS
VDISTNYHSDSLRFSNAFHSAVAPFTMAINAHTNGNGKLALWGEHTGQLYSKFLLKAEPL
VLSFSHDYKGSTSHNLLSRKSINMALDHKLSALLSPTEQSGTWKFKTQLNNNEYSQDFDV
YNTKDKIGVELSGRGLADLAVLDSPIQVPFSLSEPVNVIDALQMRDAVEQPKEFTVVAFV
KYDKNQDIHTINLPFFQTLPEYLERNRIIVITALEAIQGKLKHINIDQFVRKYGAGLDKL
PQQVEYYLNALNWERQIASAKEKLTAFAENYKITENDLQTALNHAKINLNEKLSQLQTYV
IQFDQYIKDNYDLHDLKIAIAKIIDQIIENLKILDEHYHIRENLVRTIHNLYLFVENVDF
NQMASSTASWVQNIDSQYQVRVQIQEKLQQVREQIQNIDIQELASKLKQQVEAIDGRVLL
NQVETTILFQKIKNIIEHVNFFVINLIKDFEVTEKINAFRALVHEVIKKYEVDQQIQVLI
DKSVDLAQQYKLKDIVQLLN-SVLPVDIKYYHKRLLVFIDDIVKQLKEFSFKNITEDINQ
FLGMLIKILRSFDYHQFVDETNSAVREVIQMINGDF--LDLRGKAEAL-QLFVEEVRDMF
SAFLEKLKDTKITLFVDWFKDALNSAYF---------TLEDARDRIYQMDIQRELERYLS
LIGQVYNTLVTYISDWWILTAKNLTDFAEQYSIQDWADNVKALVEQGFTVPEIQTVLGTL
PAVEISLRALQQASFQTPDFIIPLTDLRIPSIQINFKELKDIKIPSRFSTPEFIILNTFH
IPSFTIDFLEIKVKILRTIDQMLYSEFQWPVPEVYLRDLKVEHILPARLTLPDFHLPAIT
VPEFVIPNLNFTEFEVPDLHIPEFQLPLIPQAAEIPAFGKLNSVLKIQSPLFTIDAKADI
HNVTT-SEHQAGLEASFGAKGESKFTVFNFDFQANAQLLEPKA--SPLFLKESMNFSSKY
LRMEHESEILFSINAIEGKSDTVASLRTEKNTLELNNGVIVKIKDQLTLDSRTKYSHKLN
IPKLDFSSKADLSNNVKTLLEAGHITLASSGAGSWKWACPHFSDEGTHESRISFTAQGPL
ASLGLANKINSKHLRVTQNLAYESGFLNFSKFEIQSDVESQHVGHSILTAKGIVLLGKGK
AEITGEHNAHLNGKVIGTLKNSLFLSAQPFEITTSTNNEGNLKVSFPLKLTGKIDFLNNY
ALLLSPAAQQTSWQASARFNQYKYNQNFSATNNENRIEAHVSINGDANLDFLNIPLTIPE
MN--LPYTALRTPS-VKDFSIWEETGLKEFLKTTKQSFDLNVKIQYKKNKDKHSIAVPLG
VFYKFISQNVNSLDSYFENVRDNALEFLTTSYNKAKIKWDKYKAEKSLNTLPRTFRNPGY
TIPV---ANIEVSSFSVEMLPFSHVIPKVINTSSFTIPGSDFYIPSYTLVLP-SLELPEL
HIPRNLLKLSLPDFKELSAVNNIFIPAMGNITYDFSFKSSVITLNTNAGLYNQSDIVVHF
LSSSSLVIDALQYKLEGTSRLTRKRGLKLATALSLS-NTFVEGSHDSTISLTKKTMEASA
TTTAKVNTPVLRLNFKQELTGNPKSKPSVSSFIELKYDFNSPKLLPTAKGAIDHKLSLES
L-----TSYFSIESSTKVDIKGAVLS-REYSGILASEASTYLNSKATRSSVKLQGSSKVD
GLWNVEVKESFAGETTVLQLYAMWEHSMKNHLQPYRHFSTHGEHASKATLELSPGALSAL
IQIRAREINSVLDIPHFGQEVALNANTKNQKFNWKSDVQVRFGTLQNSLQISNDQKEARL
HIAGSLGGHLRFLKFIILPVYDKSLWDLLKLD-------RQYLHATTALVYTKNPKGYPL
SVPVQELTDKFI--IPGLKLNHLN--------------------------SD--LTLSTS
PFALSLPTLPKIKFPQVDVLTQYSKPEDSSVPFFEIIVPEVQLTISQFNLPKSLSVGSAV
LDLNKVAHMIGDLELPTITVPEQTIEIPSLKFSVPAGIFIPLFGALTARFGVSSPLYNTT
WNVGLKNNADHIETFLDSTCSSTLQFLEYDLNVVGIHKIEDGMLSCKTEGTLAHRDLSAD
YKEDGKFKGLQDWEGEMSLDIISPDFTELHLHYQSNEN-SVSSSAASPAIGTVGLNLEKE
GDHSVKWNF---YFQ-PQSSPDKKLSIFKTEWK--YQVSGDE-VLKLNWEEEAAS-RLLD
SLKDNVPKATGAFYDYVDKYHQEYASSKLR-------RSLQESAEGAYQKATRQLHEM--
-EA--------------QLYKAEDLYQELL-AEEGQDNSQRIKDKVFDSLMQITQESQMA
VKYWIDSFIDFLKLTRIQLPGTTRTYTRDELCTMVMRKIAKGLSQVYSGIHNGLEKLLSY
AQDLMEQSELMKDLQIEFPFYSGRYK---------LTEVILNYRKQLD----SLSQD---
------STKF-SEKLRDLQSLL-QRVFQEIEAEIKSLKETRFIHLINT----INTIFNTY
IPFAFNVLKESLCLHLTKLN----NFVQINLQFASQGLQQIHQHMQALRKEYFDPGVIGW
TVKYYELEEKIIDMIMNIVVSLKDFHAIYTARATNFVSQLSTWVEQFVREDVQEYLSILA
DADGKGREKIAEFSNTTQKVIKTLATAMREIISDYQE

PF12491 // ENSGT00590000083139_0_Domain_6 (4658, 4713)

QFTSKLQQLSDQFSDYQEKFIAE
YQRLIDLSIQNYHMFLRFITELLKKLQA-ATASGESPYIRLAPGELIITY----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------

------------------------------------------------------------
--------------------CPWEHYFYHVADFF-LLISEDATR

PF01347 // ENSGT00590000083139_0_Domain_0 (105, 673)

FKHLRKYIYNYEAESS
SGVPGTADSRSATKINCKVELEVPQLCSIILKTNQCTLKEVYGFNSEGKALLKKTKNSEE
FTAAMSKYEL-KLTIPQGKQVFLYPEKDEPQHILNIKRGIISALLVPLETEEATQVL---
FLDTVYGNCSTHFTVKTRKGNVATEISTERD----LGQCDRFKPTSTGVSPLALIKGMTR
PLSTLISSSQSC-QYTLDSKRKHVAEAVCREQHLFLPFSYKNKYGIMAQVTQTLKLEDMP
--KINSRFFGEG-AKKVGLAFESTKSTSPPKQ-AEAALKTLQELKKLSVSEQNRQRAYLF
SKLVTELRGLSNEAVTSLLPQLIEVSS--PITLQALVQCGQPQCYTHILQWLKGTHASPL
LIDTVTYLVALISEPSAQRIREIFNMAREQRSRATLYALSHVVNNYYK-TNPTETQDL-L
DIADYLLGQIQNECTGDEDHTYLILRVIGNMGQTMERLTPRLKSSILECVKSTKPSLLIQ
KAAIQALRKMELNNEDQGVLLQTFLDSASPGDKRLAAYLMVMRDPSQSDIDKITQRLPEE
QNEQVRNFVASH

ENSGT00590000083139_0_Linker_0_3 (673, 709)

ISNILKSEELYVQDLKVLLEEALKQVP-VPAVRDFR

PF09172 // ENSGT00590000083139_0_Domain_3 (709, 1017)

KFSRNYQFSKSV
SLPSLD-SASAKIEGNLMFDPNNYLPTESMLKTTLTIFGFASADLFEIGLEGKGFEPTLE
ALFGKQGFFPDSISKALYWANGRVPDHVSKVLVDHFGYPKDDKSGQDMANGIMLNVEKLI
KDLKSKDVPEARAYLRILGEELGFARLQDLNLLGRLLLTGARTLTGIPQMIG-EAISKGS
KGDFFLHYIFMDNAFELPTGVGLQLQMSSSGVITPGTKAGAKLEMA-NMQAELVVKPSVS
VEFVTNMGIIIPDFARSGVQMNTNFFHESGLQARVALKAGQLKFIVPSPKRPVKLF

ENSGT00590000083139_0_Linker_3_5 (1017, 1044)

SGSN
TLHLVSTT----KTEAIPPLIEN

PF06448 // ENSGT00590000083139_0_Domain_5 (1044, 1155)

RQSWSACKPFFTGLNYCTSG-AYSNASSTDSTSYYPL
TGDTRFELELRPTGEVEQYSVSATYELQREDRALVDTLKFVTQAEGMKPTEATMAFKYNR
QTMTLSSEVQIPDF

ENSGT00590000083139_0_Linker_5_6 (1155, 4658)

GIDLGTILRVNDDSAENKKSYKLTMDVQNKKITEVTLMGHINWDTK
EEAKIKGVISIPRLQAEARSEILTHWSPTKLLLQMDSS--ATAFGSTVSKRVAWRYDEEK
IEFEWNTGTNVDTKKVASNFPV----DFSDYPRSLHMYANSLLDHRVPQTDMTFRHMGSK
LIVATNTWLQKAAESLPYAQTLQDHLNGLKELDLQNVGLPDFHIPENLFLKSDGRVKYTL
NKNSVKIEIPLPFGGKSSKDLKMLETVRTPALHFKSVGFHLPSREFQVPTFTIPELYQLQ
VPLLGVLDLSTNVYSNLYNWSASYSGGNTST-E--HFSLRGQYHVKADSVVDLLSYNVQG
SGETTYDHRNTFTLSCDGSLRHKF-LDSNIKFSHVEKLGNSPLSKGL---LTFDASSALG
PQMSAAVHLNSKKKQHLYVKEVKIEGQFKVSSFYAKGTYGLSYQKDPATGQLNGESNLRF
NSTYLQGTNQITGRYEDGTLSLTSTSDLQGGIIKNTASLKYENYELILKSDTNGKHENFA
TSNKMDLTFSKQNALLRSEYQVDYKSLRFFTLLSGSLNSHGLELNADTLGTDKINSGAHK
ATLRITRDGISTSATTNLKYSPLVLENELNAELGLAGASMKLTTNGRFREHGAKFNLDGK
AALTEVSLGSTYQAMILGVDSKNIFSFKISQEGLMLSNNLMGSYAEMKLDHTNSLNIAGL
SLDFSSKLDNFYSRDKFYKQNFNLQLQPYSLVTTLHNDLKYNALDLTNSGKLRLEPLKLN
VGGNLKGTYQNNEIKHIYTISYAALS-ASYKADT---VAKIQGVEFSHRLNTDIAGLASA
IDISTNYNSDSLHFSNVFHSVMAPFTMTVDAHTNGNGKLTLWGEHTGQLYSKFLLKAEPL
ALTFSHDYKGSTSHHLMSRKSVSTALDHKVSALLTPAEQTGTWKLKTQFNNNEYSQDLDA
YNTKDKIGVELSGRALADLTILDSPIKVPLLLSEPVNVIDALEIKDAIDKPQEFTIVAFV
KYDKNQDVHTINLPFFTTLQEYFEMNQRIIRTVLESIQRELKRINIDQFMRNYRAALGRL
PQQVDDYLNSFNWERQVSSAKEKLTAFTKNYRITENDLQIALDNAKINFNEKLSQLQTYV
IQFDQYVKDNYDLHDFKTAIAKIIDRIIEKLKLLDEQYHIRVNVAKTIHNLYLFIENVDF
NKIGSSTASWIQNVDTKYRIRIQIQEKLQQLMTHIQNTDIQNIAGKLKQQVEAVDIRVLL
DQVRATIPFKRINDILEHVKYFVINLIGDFEVTEKINAFRAKVHELIKKHEIDQKIQVLM
DKSVQLAYQYNLKETVQKLSNVLQQVEIKDYFEKLVGFIDEAVKKLDALSLKEFIEEVNR
FLDMLVKKLKSFDYHQFVDESNNKIREVTQRINSEIQALELPQKVEIL-KLFLKDTKALA
EVCLESLKDTKVTLIIDWLQDTLSSASLAHMKAKLQETLEDIRDRIYQMDIQQELERYLS
LMGQVYSTLVTYISDWWILAAKNLTDFAEQYSIQDWAERVKTLVEQGFTVPQIQTILGTM
PAFRVSLRALQEATFQTPDFIVPLTDLRIPSIQLNFKELKDIKIPSRFSTPEFTVLNTFH
IPSFTIDLVEIKVKIIRTIDQMLNSELQWPVPEVYLRDLKVEDTLLAGITLPDFHLPEIT
IPEFVIPKLSLNDFQAPDLHIPEFQLPHISQTIEVPTFGKLYSVLKIQSPLFTLDVNANM
QNVTT-SGNKADIAASIAAKGESKLEVLNFDFQANAQLSNPEI--NPLVLKESMKFSSKY
LRTEHESEMLFFGNAIEGKSDTVARLHTEKNTLELSNGMIVKMNNQLTLDSNTKYFHKLN
IPKLDFSSQADLRNEIKTLLETGRIAWTSSGAGSWKWASPNFSDEGTHESQISFTVGESI
TSFGLSNKINSKHLRVNQNLVYESSFPKFSKFEIQSQVESQHVGRSVLTAKGTALFREGK
AEITGNHDAHLNGKVIGTLKNSLLFSLQMFEITASTNNEGNLKVSFPLKLTGKIDFLNNY
ALFLSPSVQQTSWQASARFNQYKYNQNFSAGNNENIMETHIGLNGEANLDFLSIPLTIPE
MT--LPYTTITTPP-LKDFSLWEKTGLKEFLKTTKQSFDLSVKAQYKKSKGRHSIANPLG
VFYKFIGQNLNSFGRHFEKARKNALDFFTNYYNEAKIKLDRYKVEKSHDELPRTFQIPGY
TIPV---VNIEVSPFTVEMLAFGYVIPKAMSTPSITILGSNIFVPSYTLVFPLDLDLPVL
HVPRNLFMLSLPDFKELSTGNNIFIPAMGNITYDFSFKSSVITLNTNAGLYNQSDIVAHL
LSSSSSVIDALQYKLEGTSSLTRKRGLKLATALSLN-NKFVEGSHDSTVSLTKKNMEASV
TTTAKVQIPILRMNFKQELNGNTKSKPTVSSSMELKYDFNSPVLYSTAKGIIDHKFTLES
L-----TSYFSIESSTKGDVKGSVLS-QEYSGNIASEASTYLNSKGTRSSLKLQGASKVD
DIWNLEVKENFAGEATFRRIYAIWEHNTKNHLELEGLFFIFGEHTSKATLELSPWKMSTL
VQVHSSQRSSLLDIPYLGQEVTLNANTKTQKVNWKNVVRVHSGSLQSHVELSNDQEKAHL
DMAGSLEGQLSFLKYIILPVYDKSLWDLLKLDVTTSIDRRQYLHASTAIVYTKNPNGYSF
SVPVKVLTDEFI--IPRLKQNDLSSVLVTPMFQVPFTDLKVPSYKLDFSEIKIYKKLSTS
SFALNLPMLPKVKFPKVDVLTKYSQPEDSSVPFFEITVPESQLTVSQFTLPRGISVGNTV
LDLNEVANKIADFELPTIIMPEQTIDIPSIKFSVPAGIFIPSFGALSARFRVASPLYNAT
WNAGLKNKEGHVETFLDSTCSSTLQILEYDLNVVETHRIEDGMLVCKTKGTLAHRDFSAE
YEEAGRYKGLQEWEGKAHLDITSPAFTDLHLHYQEKEK-SLSISVASSTLGTVGMDLEDD
E-KFFTWNF---YYR-PQSSPDKNLTILKTELR--DQESDEEIQIKVNWEEEAAS-GLLI
SLKDNIPKATGALYDYVNKYHWEHTGLTLRDASSKLRRSLQNNAERAYQNAMRQIDEMD-
-MRFQRVTSGATGAYQEWKDKAQNLYQEML-AQEGQTNFERLKDKLIDNLVQVTQEFHMT
IQRLVDSFTDFLKYTKFQLPGKAGTYS--ELCTMVMREVRKVLSQVYSSIHEGLEILLSY
IQDLV----------IRFPFEPRSHK---------LIDVIPEIIELLK----SVSQEVQM
TLDNTHLNKT-IEMLSDLRGPL-QFIFRSLEKEIKYLKKAKFTYIINDIQYEIDRTFNKY
IPYVFGILKENLCIILDKLN----ELVQNKLQEASQSLQQIHQYIKALREEYFDPSVVGW
TVKYYELEEKVVSLMENLVIALKDFHSTYSLSTADFASQLSDQYEQFV----QEYLSILT
DPDGKGKEKIAELSTTAQEIIKSWAVSMKKIISDYHQ

PF12491 // ENSGT00590000083139_0_Domain_6 (4658, 4710)

QFRYKLQDFSDQLSDYYEKFIVE
STRLIDLSIQNYHMFLRYITELLKKLQS-TKS--MSPYIKLAPGELIITL----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------

-----------------------------------------------MGAPRPAL-----
---------PLLLLAVLLAAACVRAQDEVVENVG-PSCPKDATR

PF01347 // ENSGT00590000083139_0_Domain_0 (105, 673)

FKHLRKYVYNYEAESS
SGVPGTTDSRSATKINCKVELEVPHLCSFILRTNQCILREVYGFNPEGEALLRKTKNSDE
FAAAMSRHEL-RLAIPEGKQVFLYPETDEPKHILNIKRGIISALLAPPETEEATQEL---
FLDTVYGNCSTHVTVKTRKGNVATELSTERN----LQQCEGFQPMSTGASPLALIKGVIR
PLSTLISSSQSC-RYLLDSKRKHVSEATCEEQHLFLPFSHKNKYGMMAHVTQSLKLEETP
--KVNSRFFTEG-TQRVGLAFENTKSTSPPKQ-TEPVLKTLQELRALSVSEQNAQRANLF
NKLVTELRGLSSEAVASLLPQLIEVSS--PITLQALVQCGQPQCYTHILQWLKSVDANPL
LIDVVTYLLALIPEPSEQRLQEIFSVTKEQQSRATFYALSHVVNSYHM-TTRRVTQGL-Q
DIADYLVEQIGTECNGDEDRTYLILRAIGNMGRTMEQVTPRVKYSVLKCIKSTRPSLLIQ
KAAIQALRKMEITDEVQGVLLQTFLNDTSPVDKRLAAYLMLIRGASQSAINQIAQLLPGE
RNEQVKNFVASH

ENSGT00590000083139_0_Linker_0_3 (673, 709)

LANILNSEELYIQDLKNVVKEALRESQ-LPTVMDFR

PF09172 // ENSGT00590000083139_0_Domain_3 (709, 1025)

KFSRNYQLSKSV
SLPSLD-PVSAKIEGNMIFDPNNYLPKESMLKTTLTVFGFAPADLFEIGLEGKGFEPTLE
ALFGKQGFFPDSVNKALYWVDGQVPDYVSKVLMDHFGYTKGDKREQDMVNGMMLSADKLI
KDLKSKEIPEARAYLRVLGEELGFVRLRDLQLVGKMLLSGAHMLQGIPRLIG-EAIRKGS
KEDLFLHYIFMDNAFVLPTGVGLQLHVSSSGVITPGTKAGVKLDVG-HMQAELALKPSVA
VEFVTSMGIILPDFARSSIQMNTNFFHESGLEARLALKAGQLKFIVPSPKRPVKLFSGSN
TLHL

ENSGT00590000083139_0_Linker_3_5 (1025, 1042)

VSTT----KTEVIPPLT

PF06448 // ENSGT00590000083139_0_Domain_5 (1042, 1156)

ENRQSWSTCRSFFTGLNYCITG-AYSKANSTDSASYHPL
TGDTRFELELIPTGEVEQYSASATYELQREDTALVDTLKFVTQAEGVKQSEATMMFKYNR
QSRTLSSDIQIPDFD

ENSGT00590000083139_0_Linker_5_6 (1156, 4658)

VDFGTILRLNDESEKDKKAYKLTLDIQNKKITEVTLMGHISCDMK
GEGKIKGVISIPRLQAEARSEILTHWSPAKLLLQMDSS--ATAYGSTLSKRVAWRYDDEK
IEFEWNTGTNVDTKKMASNFPV----DLSDYPRSFHAYANNLLDYRVPQTDMTFRHMGSK
LIVATNSWLQKASRSLPYAQTLQDHLSGLQELNLQKMGLPDFHIPENLFLKSDGRVKYTL
NKNTVKIEIPLPFGGKSFKDLKMLKTIRTPALNFHSVGFYIPPQEFQVPTFTIPKLYQLR
VPLLGILDLSTNIYSNLYNWSASYTGGNTSA-D--QFILRARYHVKADSVVDLLSYSVQG
SGETTYDHRNTFTLSCDGALHHKF-LHSNIKFSHVEKVGSNPASKGL---LTFDASSTWG
PQMSASVQLDSKKKQQLYVKEVKMDGQFRASSFYAKGTYGLSCQRDLTTGWLSGESNLKF
NSSYFQGTNQITGRYQDGTLSLASTSDLQGGIFKNTASLKYENYELTLKSDTNGKYEEFA
TSNKVDLTFSKQNALLRAEYQADYKSLRFFTLLSGLLNTHGLELNADILGTDKMNTAAHK
ATLRIGQNGVSTSATTSLRYSPLMLENELNAELALSGASMKLATNGRFKEHNAKFSLDGK
ATLTELSLGSAYQAMILGADSKNIFNFKISKEGLKLSNDMMGAYAGMKFDYTNNLNIVGL
SLELSSKLDNIYSSDKFYKQNFNLQLQPYSLVTTVNNDLKYSTFGLTSSGKLRLEPLKLN
MAGDLKGAYQNDEIKHSYIISYADLS-ASYKAET---VAKVQDMRFNHRINTDIAGLASS
VDVSTNYNSDSLHFNNVFHSVLAPFTLTIDTLTNGNGKLVLWGEHTGKLYSKFLLKAEPL
AFTFSHDYQGSIRHHLLTRGSVSTTLDHKVSALLTPAEQRGTWKLKTQINNNEYSQDFDA
YNTKDKIGVELSGRVLADLTMLDTPIKVPLLLSEPINIIDALKMKDAIDKPQEFTIVSFV
KYDKNQDVHTINLPFLNSLPKYFEKNRMVIITVLETIQRELKRINIDPFLRRYRTTLGKL
PQQVNDYLSTFNWERQVSSAKEKLTTFTKNYKITENDIQTALDNAKINLNEKLSQLQTYV
IQFDQYIKDNFDLHDFKIAIASIIDQIMEKLKILDERYHIRAHLIKSIHNLYLFIEAIDF
NKIGSSTASWIQNVDTKYQVRIWIQEILQQFKTQIQNTNIPYLAEKLKQQIEAIDVRVLL
DQLRTTIPFRIIKDIIEHFKYFVINIIENFEVIDKINTFRATAHELIKKYEVDQQIQNIV
DRLVDLAQQYKLKDTVQKLSNVLQRVEIQDYFEKLVGFVDDAVKQLKALSFEKLIEEVNR
FIDMLVRKLKSFDYHQFVDETNSKIRELTQMINGEIQALEISQKAEAL-KLFVEDIKAMV
LDCLERLRDTKVTLFIDGLQEALNSISLIHMKAKFLETLEDIRDRVYQMDIQRELARYLS
LVGQVYSTLVTYISDWWSLAAKNLTDFAEQYSIQDWAENLKALVEQGFTVPEIQTIIGTM
PAFEVSLHALRKATFQTPDFTVPFTDLRIPSVQINFKELKDIKIPSRFSTPEFTILGTFH
IPSFTIDLVEIKVRFIRTIDQMLNSELQWPIPEVYLKDLKV-DTLLARITLPNFRVPEIT
IPEFILPNLSLKDLQVPDLHIPEFQLPHISHTVQVPTLGKLYSVLKIQSPLFTLDANADI
KNKTT-SVEKVEIAASIAAKGQSKLEVLNFAFQADAQLSNSKI--NPPFLKESMKFSSKY
LSTEHESELLFFRNAIEGKSDTVASLHTEKNTVKLNNSVIFKINNQLTLESTTNYSHILN
VPSLDISSQADLHNEIKTLLEAGHVTWTSSGTGTWKWACPKFSDEGTHESQIGFTVKGPI
TSFGLSNNINSKHLRVNQNLAYHSDFFNFSKFEIQSHIESQHMGHSILSAKGTALLGEGK
AEVTGNHVALLNGKVTGTLKNSLSISAQPFEIVASTNNEGNLKVSFPLKLTGKINFLNNY
ALFLNPSAQQANWQANARFNQYKYNQNFSVGNDENSIEAHMGINGEANLDFLNIPLTIPE
IN--LPYTTLTTPP-LKDFSLWEKTGLKEFLKTTKQSFDLNINAKYKKNKEKHSIAIPLG
AFYKFISQNINSFSGHLQNIGDNALDFLTKSYNEAKIKFDKYKVEKSLNRLPRTFQTPGY
IIPI---FNIEVSPLTIETSAFSHVIPKSISTPNVTILDSSFYVPSYTLALP-SLELPVF
HVPRNLLKVSLPDFKELKTINNIFIPAMGNITYEFSFKSTIITLNTNAGLYNQSDIVAHI
LSSSSSVIDALQYKLEGTSSLTRKRGLKLATTLSLN-NKFLGGTHDSTISLTKKNMEASS
TTTADVQTPILRTNFKQEFNGNTKSKPTISSSIELKYDFNFPKLSSTAKGEVKHKLSLES
L-----TSYFSIESSSKGDIKGSFLS-QEYSGAIASEASTYLNSKGTRSSVKLQGASKLH
DIWNLEVKENFAGEATLQRIYAIWEHNAKNSLQIEHFFHTHGEQASKATLELSPWTMSAL
VQIHASQPNCLLDTTYLDQEVALNANTKNQKVIWKSEVQFNLSSLQNNVQLSNDPRETRL
DIAGSLEGHLSFLKNIIIPVYDKSAWDLLKLDVTTSTSRRQYLRASTALVYTKNPNGYAF
SLPVQELADKFI--IPGLKLNDLDLVLVTPTFQVPFVNLLVPSYKLDFSEIKIYKKLSTS
PFALNLSILPNVKFPKVDVLTKYSELQDYSVPFFEITIPEAQVTVSQFTLPKSISVGSTV
LNLNDVANKIADFELPSTIVPEQTIEIPSTKFSVPTGIFIPFFGTLTAQFGLASPLYNVT
WSAGLKNKEDHIETFLDSTCSSTIQFLEYDLNVVGTHKIEDGMFICKTRGTFAHRDFSAE
YKEDSKYKGLQVWEGEARLDITSPVFTDFHMHYQEDEK-TLSFWAASPAIGTVGMDLEDQ
E-DILMWSL---YLY-PQSSPDKKLNILKTEFR--YKESEQEAQIEVNWEEEAAS-RLVS
SLKDNMPKAMGTLYNYINKYHREHTGLNLKAASSKLQRSLQNSAEQAYQEAMRQIDEMD-
-VRLQRAASGTTRTYQGWKDQAQTLYQELL-AQKDQATSQRLKDKVIDSLVWVLQEYHMA
VKRLIDSFIDFLKFPRFQLPGKARLYSRDELCTMVMREVGKALSL---------------
----------MKDLIIKHPFKSKSYK---------PTEIILECIKMVE----LLSQEIQD
AFNKLQSIKL-TEILNDLQEIL-ECFFLRVEGEIKHLKEIKLIYAINDIQN-VINTVQDY
IAYIVRHMKENLYFNLGKFN----EFVQNKLKAASQELQQIQQHIKALRKEYFDPSVVGW
RVKSYELEEKIINVIHHLVAALKDLYSKFTAGAAGFASQLSSQVEQIVCKDIQEYLSILT
DADGKGKEKIAELATSAQEITKSWATAMKEIISDYHQ

PF12491 // ENSGT00590000083139_0_Domain_6 (4658, 4715)

QFRYKLQDLSDQLCDYPEKLVAE
SKRLIDLSIQSYHMFLRYVTELLKELQL-AAVNDMSPHIKLTPGELTITF----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------

------------------------------------------------------------
-------------------EE----M---LENVS-PVCPKDATR

PF01347 // ENSGT00590000083139_0_Domain_0 (105, 673)

FKHLRKYTYNYEAESS
SGVPGTADSRSATRINCKVELEVPQLCSFILKTSQCTLKEVYGFNPEGKALLKKTKNSEE
FAAAMSRYEL-KLAIPEGKQVFLYPEKDEPTYILNIKRGIISALLVPPETEEAKQVL---
FLDTVYGNCSTHFTVKTRKGNVATEISTERD----LGQCDRFKPIRTGISPLALIKGMTR
PLSTLISSSQSC-QYTLDAKRKHVAEAICKEQHLFLPFSYKNKYGMVAQVTQTLKLEDTP
--KINSRFFGEG-TKKMGLAFESTKSTSPPKE-AEAVLKTLQELKKLTISEQNIQRANLF
NKLVTELRGLSDEAVTSLLPQLIEVSS--PITLQALVQCGQPQCSTHILQWLKRVHANPL
LIDVVTYLVALIPEPSAQQLREIFNMARDQRSRATLYALSHAVNNYHK-TNPTGTQEL-L
DIANYLMEQIQDDCTGDEDYTYLILRVIGNMGQTVEQLTPELKSSILKCIQSTKPSLMIQ
KAAIQALRKMEPKDKDQEVLLQTFLDDASPGDKRLAAYLMLMRSPSQADINKIVQLLPWE
QNEQVKNFVASH

ENSGT00590000083139_0_Linker_0_3 (673, 709)

IANILNSEELDIQDLKKLVKEALKESQ-LPTVMDFR

PF09172 // ENSGT00590000083139_0_Domain_3 (709, 1018)

KFSRNYQLYKSV
SLPSLD-PASAKIEGNLIFDPNNYLPKESMLKTTLTAFGFASADLIEIGLEGKGFEPTLE
ALFGKQGFFPDSVNKALYWVNGQVPDGVSKVLVDHFGYTKDDKREQDMVNGMMLRIEKLI
KDLKSKEVPEARAYLRILGEELGFARLHDLQLLGKLLLMGARTLQGIPQMIG-EVIRKGS
KNDFFLHYIFMENAFELPTGAGLQLQVSSSGVIAPGAKAGVKLEVA-NMQAELVAKPSVS
VEFVTNMGIIIPDFARSGVQMNTNFFHESGLEAHVALKAGQLKFIIPSPKRPVKLLS

ENSGT00590000083139_0_Linker_3_5 (1018, 1044)

AGN
TLHLVSTT----KTEVIPPLIEN

PF06448 // ENSGT00590000083139_0_Domain_5 (1044, 1156)

RQSWSVCKQVFPGLNYCTSG-AYSNASSTDSASYYPL
TGDTRLELELRPTGEIEQYSVSATYELQREDRALVDTLKFVTQAEGAKQTEATMTFKYNR
QSMTLSSEVQIPDFD

ENSGT00590000083139_0_Linker_5_6 (1156, 4658)

VDLGTILRVNDESTEGKTSYRLTLDIQNKKITEVALMGHLSCDTK
EERKIKGVISIPRLQAEARSEILAHWSPAKLLLQMDSS--ATAYGSTVSKRVAWHYDEEK
IEFEWNTGTNVDTKKMTSNFPV----DLSDYPKSLHMYANRLLDHRVPQTDMTFRHVGSK
LIVAMSSWLQKASGSLPYTQTLQDHLNSLKEFNLQNMGLPDFHIPENLFLKSDGRVKYTL
NKNSLKIEIPLPFGGKSSRDLKMLETVRTPALHFKSVGFHLPSREFQVPTFTIPKLYQLQ
VPLLGVLDLSTNVYSNLYNWSASYSGGNTST-D--HFSLRARYHMKADSVVHLLSYDVQG
SGETTYDHKNTFTLSCDGSLRHKF-LDSNIKFSHVEKLGNNPVSKGL---LIFDASSSWG
PQMSASVHLDSKKKQHLFVKEVKIDGQFRVSSFYAKGTYGLSCQRDPNTGRLNGESNLRF
NSSYLQGTNQITGRYEDGTLSLTSTSDLQSGIIKNTASLKYENYELTLKSDTSGKYKNFA
TSNKMDMTFSKQNALLRSEYQADYESLRFFSLLSGSLNSHGLELNADILGTDKINSGAHK
ATLRIGQDGISTSSTTNLKYSLLVLENELNAELGLSGASMKLTTNGRFREHNAKFSLDGK
AALTELSLGSAYQAMILGVDSKNIFNFKISQEGLKLSNDMMGSYAEMKFDHTNSLNIAGL
SLDFSSKLDNIYSSDKFYKQTVNLQLQPYSLVTTLNSDLKYNALDLTNNGKLRLEPLKLH
VAGNLKGAYQNNEIKHIYAISSAALS-ASYKADT---VAKVQGVEFSHRLNTDIAGLASA
VDMSTNYNSDSLHFSNVFRSVMAPFTMTIDAHTNGNGKLTLWGEHTGQLYSKFLLKAEPL
AFTFSHDYKGSTSHHLVSRKSISAALEHKVSALLTPAEQTGTWKLKTQFNNNEYSQDLDA
YNTKDKIGVELTGRTLADLTLLDSPIKVPLLLSEPINIIDALEMRDAVEKPQEFTIVAFV
KYDKNQDVHSINLPFFETLQEYFERNRQTIIVVLENVQRDLKHINIDQFVRKYRAALGKL
PQQANDYLNSFNWERQVSRAKEKLTALTKKYRITENDIQIALDDAKINFNEKLSQLQTYM
IQFDQYIKDNYDLHDLKIAIANIIDEIIEKLKSLDEHYHIRVNLVKTIHDLHLFIENIHF
NKSGSSTASWIQNVDTKYQIRIQIQEKLQQLKRHIQNIDIQHLAGKLKQHVEAIDVRVLL
DQLGTTISFERINDILEHVKHFVINLIGDFEVAEKINAFRAKVHELIERYEVDQQIQVLM
DKLVELAHQYKLKETIQKLSNVLQQVKIKDYFEKLVGFIDDAVKKLNELSFKTFIEDVNK
FLDMLIKKLKSFDYHQFVDETNDKIREVTQRLNGEIQALELPQKAEAL-KLFLEETKATV
AVYLESLQDTKITLIINWLQEALSSASLAHMKAKFRETLEDTRDRMYQMDIQQELQRYLS
LVGQVYSTLVTYISDWWTLAAKNLTDFAEQYSIQDWAKRVKALVEQGFTVPEIKTILGTM
PAFEVSLQALQKATFQTPDFIVPLTDLRIPSVQINFKELKNIKIPSRFSTPEFTILNTFH
IPSFTIDFVEMKVKIIRTIDQMLNSELQWPVPDVYLRDLKVEDIPLARITLPDFHLPEIA
IPEFIIPTLNLNDFQVPDLHIPEFQLPHISHTIEVPTFGKLYSILKIQSPLFTLDANADI
GNGTT-SANEAGIAASITAKGESKLEVLNFDFQANAQLSNPKI--NPLAVKESVKFSSKY
LRTEHGSEMLFFGNAIEGKSNTVASLHTEKNTLELSNGVIVKINNQLTLDSNTKYFHKLN
IPKLDFSSQADLRNEIKTLLKAGHIAWTSSGKGSWKWACPRFSDEGTHESQISFTIEGPL
TSFGLSNKINSKHLRVNQNLVYESGSLNFSKLEIQSRVDSQHVGHSVLTAKGTALFGEGK
AEFTGRHDAHLNGKVIGTLKNSLFFSAQPFEITASTNNEGNLKVRFPLRLTGKIDFLNNY
ALFLSPSAQQASWQVSARFNQYKYNQNFSAGNNENIMEAHVGINGEANLDFLNIPLTIPE
MR--LPYTIITTPP-LKDFSLWEKTGLKEFLKTTKQSFDLSVKAQYKKNKHRHSITNPLA
VLCEFISQSIKPFDRHFEKNRNNALDFVTKSYNETKIKFDKYKAEKSHDELPRTFQIPGY
TVPV---VNVEVSPFTIEMSAFGYVFPKAVSMPSFTILGSDIRVPSYTLILP-SLELPVL
HVPRNL-KLSLPDFKELCTISHIFIPAMGNITYDFSFKSSVITLNTNAELFNQSDIVAHL
LSSSSSVIDALQYKLEGTTRLARKRGLKLATALSLS-NKFVEGSHNSTVSLTTKNMEVSV
ATTAKAQIPILRMNFKQELNGNTKSKPTVSSSMEFKYDFNSSMLYSTAKGAVDHKLSLES
L-----TSYFSIESSTKGDVKGSVLS-REYSGTIASEANTYLNSKSTRSSVKLQGTSKID
DIWNLEVKENFAGEATLQRIYSLWEHSTKNHLQLEGLFFTNGEHTSKATLELSPWEMSAL
VQVHASQPSSFHDFPHLGQEVALNANTKNQKIRWKNEVRIHSGSFQSQVELSNDQEKAHL
DIAGSLEGHLRFLKNIILPVYEKSLWDFLKLDVTTSIGRRQHLRVSTAFVYTKNPNGYSF
SIPVKVLADKFI--IPGLKLNDLNSVLVMPTFHVPFTDLQVPSYKLDFREIQIYKKLRTS
SFALNLPTLPEVKFPEVDVVTKYSQPEDSLIPFFEITMPESQLTVSQFTLPKSVSDGIAA
LDLNAVANKIADFELPTIIVPEQTIEIPSIKFSVPAGIVIPSFQALTARFEVDSPMYNAT
WSASLKNKADYVETVLDSTCSSTVQFLEYELNVAGTHKIEDGMLASKTKGTFAHRDFSAE
YEEDGKYEGLQEWEGKAHLNIKSPAFTDLQLHYQKDKK-GISTSAASPAIGTVGMDTDED
D-DFSTWNF---YYS-PQSSPDKKLTIFKTELR--VQESDEETQIKVNWEEEAAS-GLLT
SLKDNVPKATGALYDYVNKYHWEHTGLTLREASSKLRRNLQNNAEWVYQGAIRQIDDIE-
-VRFQKAASGTTGTYQEWKDKAQNLYQELL-TQEGQASFQGLKDKVFDGLVRVTQEFHMK
VKHLIDSLIDFLNFPRFQFPGKPGIYTREELCTMFIREVGTVLSQVYLKVHNGSEILFSY
FQDLV----------ITLPFELRKHK---------LIDVISMYRELLK----DLSKEAQE
VFKDIQSLKT-TEVLRNLQDLL-QFIFQLIEDNIKQLKEMKFTYLINYIQDEINTIFNDY
IPYVFKLLKENLCLNLHKFN----EFIQNELQESSQELQQIHQYIMALREEYFDPSIVGW
TVKYYELEEKIVSLIKNLLVALKDFHSEYIVSASDFTSQLSSQVEQFLHRNIQEYLSILT
DPDGKGKEKIAELSATAQEIIKSQATATKKIISDYHQ

PF12491 // ENSGT00590000083139_0_Domain_6 (4658, 4716)

QFRYKLQDFSDQLSDYYEKFIAE
SKRLIDLSIQNYHTFLIYITELLKKLQS-TTV--MNPYMKLAPGELTIIL----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------

--------------------------------------EEGAENQTPV------------
-------------------------------------CPXXXXX

PF01347 // ENSGT00590000083139_0_Domain_0 (105, 674)

XXXXXKYVYSYEAESA
NSVAGTADSYSATRINCKVELEVPQLCSFILKMSQCTLKEVYGFDPDGKALLRKTKNSDE
FAAALSRYEL-RLSIPNGKQVFLYPEKEEPTHILNIKRGVVSALLVPTDTEEDKRQL---
TLDTVYGNCSSDVTVRARKGNVITEVVIDRN----LEKCDGFKPISKAASPVALIKGLSG
SLSKLLSSRQEC-VYTLDPEKKHVEQAVCREQHLFLPFSYXXXXXXXXXXXXXXXXXXXX
--XXXXXXXXXXAFQKRGLALESVEATAPPRKEE-VV---LRTLQELSAAEQNEHQAKLF
SRLVTSLRALNEEAITSLWPQLLEASS--PLALQALVQCGQPQCYSHILRWLKSEKVNPL
LIDAASYIMALIPNPSAQRLREIFKVAQERPSRITLYALSHVVNKFHQ-QSTMVSQEL-K
EIADYLTSHLGNDCAGSEEATYLTLRVIGNMGRALEKASPELKASLLKCIQSPAPSLLVQ
KTAIQALRKMELTEEVQSVLVQTFLDVASPEEKRLAAYLLLMRSPPV---QHVISALQSE
KNEQVRSFVASHI

ENSGT00590000083139_0_Linker_0_3 (674, 709)

SNILASEDLSVRDLRGQVEEALQASQ-LPAAMDFR

PF09172 // ENSGT00590000083139_0_Domain_3 (709, 1025)

RFSQNYQFSKAF
SIPSFS-PFSTKVEGNLLFDSHSRLPRETMLKTTLSVFGFSPSDLFEVGLEGKGYEPTLE
ALFGKQGFFPDSAAKALYWVDGRVPDPVSKVL-DHFGYAKE-DREQDMVNGLMLTFQKLV
KDLGSREAPEAQAYLRILGEELGYVRLQDFKVMGTTLLKMVKSLRGLPQMIA-KALARGS
QSNLFVHYIFMENTIELPTGAGLPLQLSTSGLITPGVKAGMKLRVA-DMQAELVAKPSVS
VEFVTHLGVTVPDFAWSGVQMNSNLYHESGLEARLALTKGQLKLAIPAPKNPVKLFKASN
TLHL

ENSGT00590000083139_0_Linker_3_4 (1025, 1041)

ISTMTYSK---VIPPL

PF06448 // ENSGT00590000083139_0_Domain_4 (1041, 1084)

IENRKSWSDCKPFFRGLNYCSTL-AYSNASSIEAAPYYPL
TGDTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXMALTSDLQVPDLDVDLGASLRVRDQSDEENVFYSLIMDVQNSKITEATVISHVRCDRK
EQGTVGIVFSVPLLQAEARSEILVHQSPGKFLVQMDSS--VTALGTMVSKKVAWRYDEKR
LEFEWNMGSNTEARKLAPTLLS----R---YGGALYQYSQDWLDHKVSHTDMTIRHIGSK
LLAATDTWFQKASQGLPYADTLQRKLRSLQEWE-----MPELRVPDNLFLKSDGRVRYIL
NKNHVKVNIPLPFGGKSLEQLQ----LRTPALDLQALGIQWPARDFRLPPLTIPESYPLR
VPLLGVLELSTNIYSNLYNWSASYTGGNTTTDTAEHVSFQARYHMKADSALDLFSYSLQG
SGETTYDHRNTFTLSCDGSLHHAF-LDSNIKLSHVKKLGNNPASKGF---LTFDASSDLG
PQVAFSVHLESNKKLHLYVKEIKADGQLTASSWYAKSSYALSYQRDVSTGQITGESNLKF
DSSFFQATNQVMGRYGDKSLSVTSSSNLQDGAVKNTASLTYENSQLTLKSDTTGKYSDLV
AAHKLDLTLAWQSALLRSEHQVDFRTLKVFTLLSGSLSSRGLELNADLLGTDQSSSGAHK
STLRIGRDGVSTSATTNLKILPLMFENELNAALGPLGASWKVTTNARYREHSAKYSLDGK
VALMEVALGSMYQATLLGTDSKSLFNLRINKDGLTLSNDMMGSYKESKLEHVNSLVIAGW
SLDFTSKMENMLSQNKLYQQNFNLQLQPYSLLATLSNNLRYNALDLTNTGKLKLEPLKLN
LGGNVKGTYGNEEIKHIYTLTYAGLS-ASYKTDT---MGKVQGTELTHRVSANLAGLASS
IDINTAFNSESVRFSNVFHALMEPFMLAMDAHTTGNGHLTLGGKHAGQLYSKFLLKAEPL
ALTFSHDYKASSDHQLHSRRSIETTLNHKVSALFTPSEQSSTWKLKALANKNEYNHDLQT
YNTKDRVGVELRAGAVADLTVLDSYIELPSLFNEPINVIDVFDLRTVADKPQEFGLTGSI
KYDKNLNVHVINLPFLEKLPAYFERVRGAILATLQNLQQYLKRINIDHYAKQYRMALDKF
PQVVNDLLVNFNLEGQVINAKEKLIAFMENYKITVDDLQISLDNTKIRLNEIASQLQTYL
IQFDQYIKDNYDLHKLKESIIELINEKIKELRVFEENYKIRYYVMRSIQDVYEFVEKINV
NKSSH-------------GLAVQILEKLKQLNQQIQNIDFQSWADWLKGQVENIDVRVYI
EFLRTSLPIQELNNIVEYIKEIVMNLLEDYEVADKINAFRAKIHELIRKYEVHKRVQVLM
DKLVQLANQYKLKETTQKLTNSLKKLEIKAYFEKLRTFVDKAVKKPRMLSL-SLIDEVNK
LLDLLVKTLQSFDYNQFVDEANKMIHELIQKINEELRALELPQKIEAA-KLYATEVRATL
ADYLDKIKDSQLTVIADWFWDVMSSISVSDIKGRFQEILEDTRDRLYQLDIQKEIHRGLQ
TISQVYNTLVTYIVDWWLLIAKELTDFAEQYHIQDWAESLKRLVEHGFTVPEIKTALGTM
PAFEVSLQSLQGATFQTPDFIVPLTDLRIPSVQINIKKLKEIRVASQFVTPEFSILSTFV
VPSFTIDLIEIKLKIIRTIDQIMSSEFRWPLPEISLQDLKVKDTLLAALTLPDFHLPEMT
IPEIMIPKLNLNEFHVPDIQIPEFQLPHIPYTVVIPTFGKVSATLKITSPFFTLDAAGFI
ENTTI-SERSPEILASLTAEGQSTVDLLAFTFQADAHLSVPEM--EKLILKESLELSSKY
LKAKHDSEMVFWETSILWRANTLASIHTDKNTVELVNILSLKLEKQVTFDSNTKYSHKLN
LPQGDFSSQMNLHHELRMLLVLERVAMTSTGMGSWKWAFPHFSDEGVHKSLLNFTVEGPV
VSLDLSNTISSKHLKVNQKLSSESGFLDFAKLEIQSDIQSQHVGQSVLNVRGSGTLEEMK
AVLIGTHNALLNGRVTGTLKNSLYFVVVPFQVDAEVNNEGNVKVSFPLKLTGKIDFLNNY
ALVLSCYVQQVNWQSGARFNQYRYSQNFSAGNYENSLEAHLSMNGEANLDFLNIPLTIPE
MT--LPYTKVMTPP-LRDFSLWERTGLKDFLKTTKQSFDLSVNAQYKKNTDRHFIPFPLG
AVYDVLSPDISAVHHHFEKGRDKMLDFLTKSYNKAKVKFDKYKVETSLDKLPRTIRIPGY
YIPF---VNIVVSPFTAEMPTIGYMVPKEMSTPGFTIPGIGFSLPSYTFVLP-SLEFPVL
HLPTSLQKLTLPDFEIPRPSDHIPIPALGNFTYGFSFKSSVITLNTNVGLHNHSDIVAHF
RSSSFSVIDALQYKLDGTTSLTRKRGLKLATALSL-NNRFVEGNHDSTISLTKKNMEASV
STMAKVQCPVLRVNLQQELSGNTKSKPMISSSIKLKYDFNSAQLQSSAKGNVDHKLTVES
F-----APYLAIETDTKGSMSGLVLS-QKYSGTVSSEVHSYLDTKSMRSSAKLEGASKVN
GVWDVEAKESFAGEASEGHFYIVWEHRGKNQLQLRRGFSTNGEQNSKVSLELAPWKASSV
IQLHVSQPSSLQ-EGLLGQLVTLTASLKDQRASWKGEGHIQTTSLSHNLQLSNDPTAIRL
DVTSSLEGYMSFLRDILLPVYDRSLWDILKLDVTTSADKKQHLHISSALVYTKSNHGSWF
SIPVKETADEFI--ISGPELVMLTPS-------------------ASLGAPEVGKKTSMA
PFVLSLPSLPQVKFPRVEVSTEYSASEGSTLPFFGVTVPEFQITLSPFTLPKKLPLAGAV
LNLNEVAKKIADSDLPSITMSEQSIRVPTLTFWLPAGIFLPSFGALAGDFQVASPVYNTS
WSASLKKKEDHVETMLDATCSSTVQLLEYDLKYGATYAFEDGALVGKVSGTFSHPVLSAE
YEDSFRAQGLEILEESATLNVTSPTFTDVLMNYQKRRG-SFSLMISSPPIGTLVLDSQKS
S-QVLQEKI---YYH-PKVSPERKLDLVEMVMR--VLISQL----SVTWNEEATS-ELAQ
TLRATWPRAAETLYHYVDKCHREQMGMDIGSTSTKLQRLLQKRADEAYHGALNRIDEVD-
-FALRQAVSKAAGTFQQWEDSTQHLYQVQ------QVNLWDLKNKAFDGALRLTQEYHKK
TLPLMDSGIELLKVSRFQLPGQADQYTGEEIYSMVLQQAGKALSRACSRVHRALEALISY
IKDLV----------RRP------SD---------LRKQLVELGESLEAFSENV----QH
RLNLLQEVKF-SDILIPCG-HS-LTIFQHIEESLKILKEKTFASLKNEFLDIVG-F----
ISELTPQVLIYLQDNLQHLH----SFVLTQFQEISRKLGQFQDWVKTLREEYFDPNVIGW
TVKYYEIEDKFIHLVQKLIDALKDFQSEVFEGFLTWVSKVTDEVERLTNTNVQEYLALLR
DADGKGKERLREVSMAAQERISGWTTIAKRKAAEYHQQLIGQLQDASGRLAG-YAGATDK
VSRLISLSVQGYQAFLKYVAELLHSIGG-STTV--NTYIQVHPEQLTIIVPY--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------

-----------------------------------------------MGPVQL-------
----------LLL--LLLLSSGVLTQEGTPENGN-PGCSKDAAR

PF01347 // ENSGT00590000083139_0_Domain_0 (105, 673)

FKSLRKYVYLYEAETS
SGITGTADSHSGSKITCKVELEVPQLCQFILRTMHCSLRETFGVDSERRAMLRKSKNSDD
FANAMSKHEL-RFSTQDGTKVKLYPEKDEPLNVLNLKRGIISALLAPTETEENIKTI---
SMDTVYGKCDSEVEFKSRRGSVAEDISINRN----LKACDNFSPIRDYVSPVAIVKGLNI
PLSTLLSSTQSC-HYSIDAKKKHIRDVVCSEKHLFLPSSYKNQYGMMTEVNQTLKLEDNQ
--RMNNRNPDGDELEEKGLALESTDAKFSR--QGDAVLKILQELQKLTASQQNQQRAKLF
YKFVSGLRSLHNSTLGSLVPKMMETSS--SITIQALIQCGTPECYSAVLQILRTGNVNPL
VVDLVTYTLGLLPSPTPKRIREILNMAQYQPSRASFYGLSHAVTKFYS-EKMIVTEEI-T
DVADFMVSLLGTDCSGDAELTYLTLRAIGNMGAVMEKAKPSLKASLKTCIRNQAASLSVQ
KAAIQAFRKMTITEEDRSALLKEFQEGDAPTDKRLATYLILMKNPSPADLAKIMRILTRE
KNEQVKSFVASH

ENSGT00590000083139_0_Linker_0_3 (673, 709)

IANILDSDEVGIEDLKSHVEEALKGNE-VPTAKDFR

PF09172 // ENSGT00590000083139_0_Domain_3 (709, 1018)

KFSQNYQVSKRV
SVPGLN-PISAKVEGNVIFDPSSYVPKETMLKTTLNLYGFGPSDIFELGLDGKGFEPTLE
ALFGEKGFFPDTASKALYWVDGKVPEQVSKALFDYFGYSHDGKQDQEITKAVILNLEKLI
KELSKKEAPEGRAFLRILGEELGYMKLSDFKLLGSVALECIKTLQRIPEIIA-QAISKGV
DKDLFVHYMFMDNEFELPTGAGLQLKFALSGIVTPGAKVAVKLHQK-SMQAELIAKPSVA
VEFVTHLGINMPEFARSGVEMNSNIFHESGIEAHVSVKAGQLKFSIPAPKTPTKLLS

ENSGT00590000083139_0_Linker_3_5 (1018, 1045)

ISN
TLHLVSPA----KTEEIPPLIENR

PF06448 // ENSGT00590000083139_0_Domain_5 (1045, 1156)

EFSTSCKPFISGLNFCTKL-LYSNASSMEAAPYYPL
TGETRFEVEIVSTGEVKEYSASANYDLQREGTDLVDTLKFAVQAEGVKQHEATLTFKYNR
DRKILTSDVSIPDVD

ENSGT00590000083139_0_Linker_5_6 (1156, 4658)

VDFGTNFRITDESVSGKKAYTFVIDFNNKKISEVTLTGQIRYAGI
EEAMLRGTVSIPRLQTELKTEALVNYSPTKGYLQMSSS--VGTHGNTVSKRVLLRYDSEK
AELEWNSGATAAVGRMSSAFQV----DFSDYSKTLEKYANELLDRKVALTDMTMRHIVSQ
FIVATNTWLQKASKDVPYAQTLQAKLSGLQELNIQKIKLPVITIPEELFLKSEGRIKYSF
NKNSFLINIPLPFGGRSSHDIRVPQTVKTPRLVIESMGINIPSQEYRMPTFTVPESYPLL
VPLFGALEASASVHSNYYNWTAAYTLTNSSTEK--TARIGTTYAVNADSVFELLSYNMKG
SGEASSS-RNGFTCAYENHLKHRL-LTSDFKMSRTKSYEPTSVSNCT---IFLMASSALG
PQLSFSSDVVSEKTNNMNINNVRIEGQLEVASVFARSVYTMSSSYNEKRRVLEGKSNLRL
DSSYLQATNHLSGRYTDGVFSITSASDVQNGLLKNTASLKYENSQLKITSETNGRYLHLA
AVNKLEFLLSKKMAALRSEYQATYKQTQCYALFTGSLNSQDLVFNTDFSLTDQRNRAAHK
SSLNVNQYGLASSATTNVQFSPLTMQSEMNAKLDTSGGSVSLSSSGRYGKNNAKFNVGGR
VSLTEITLGSEYQSTILGMDNKHVLNFRINKEGLKFSNNLQGSLKEIKLEYTNDLNIPGL
SLTFVSKLDNSFSFDKFHKHVFDLQLQPRSLTAKLNNNIKYTKTEVSNKAELLLEPLKLN
LGGNVRAAYGTDEVRHTYAITYADLT-ANFKTDT---VANVQGAAVSHRVNLNVAGLASS
ITMNTNCDSKSLRFSNALRSTMAPFTITADVHTNGNGKLIALGEHTGDLYSKILFKAEPL
AFTFSHDYRGSTSHSFKSMRRYSTQLDNKFHMLFTPSEQSSAWKLKSQLNNNIYSQDINA
YNDAEKIGVELSGRALADLSVVDTAIRLPFT-SEEVNVIDVLGLRDSVSEPQEFSISGSV
KYDKNKDMHVINLPFLEHFPVYFEQIRGAILSTLQAVQNYLKNIDIDQYMKKYKATLDEF
PQHLNDYMDKLDLKGRASTIKTNLIAFTKDYRITSDDLEIILEKALDNLQEILLQLQVYL
VQIEQYIKENYDQFDINALIAQLLDKIVEKMTALDEKYKIRVTVVDTIQKLQFFLNQYYP
SNIGSSTMTWIKNIDDEYRITGRIKENLEQLKIQIQNIDIRSFAENLKRKIKITDVKQLL
EKLKRSLPIKKMKEVLEQIKDFILSWMEEYEVSEKISAFRGHMHKLIVKYEIDKHVYFLL
DRMIELLNQYRIRETVRKMTTYLRKIDLKTCFDKIVSLIDDAVKKVQTFDYEMMIKKLNK
FLDMIIKKLKSFDYNQFVDDTNNKIQEIIQKINEELRNLELPQKAEAL-KQYMRDFNAVV
SKYVEQLRDTKLVAIINWLKELIDSTTFTNLKAKVNEHLEDLRERISDMDISKEFEWYLQ
KISQFYNSVVIYISEQWNIAFKKIVTLAEKYDLKNWAENLNQFIETGFKVPEIRTVIVTI
PAFEFSLRSLREATFRTPDFIVPLTDLKIPSYEINIRRLKDMKIPAKFTTPEFTVLNSFK
VPSYTIDLNEIKFQIVRMIDQLISGEFQLPAIDLYFKDLKMRDMPFSEISFPELQMPQLE
IPELLIPKLNLNEFQIPDLKIPEFQLPRIPHTVTAPTFGKLSGAFRVASPFFTLSTQAEV
HNTTA-SANSPEFVTSLSAQATSKLDFLVFSVIADSHILAPEM--KQLKLKNSMKVSHKF
LKIDHTNEVVFLGTSVSGEAETRAKFSAIKNSIELQNNLMVNLQRKIQMQSGTAYSHRLN
IPEADFSSQADLVNNMTTEVEAGRISFTSNGKGNWKWTSPNFSDEGTHNSHATFRVDGPI
LIFFADYRINDRYLKVSQSMRYECGFLSYATLQVQSEIESQRVGRSILNVKGTGQLGGMK
VELTGSHNARLNGRITGTVNNDFFFLVQPFEIRLLTNNDGNVKISFPMKLTGKIDFLNNY
GLSLSSSVQQVSWQATGRFNQYRYSHNMSAGNNDDRIEAHVEMSGDANLDFLNIPLTIPQ
LH--IPYTGIQTPQ-LKDYSLWEQAGLKNLLKTTRQSFDLNLNAQYEKNKDMHVIPLPLA
TVHEALNKYIIFFNKYFERGRNTALDFLTKSYNEAKTKFDKYKIQTSLNKLPRTFRIPGY
TIPI---VNIEVSPFTAEMPAFGYVLPKEISTTGFTVPFIGFSVPSYTLVLP-SLELPVL
HVPQDLRTLKLPRFRINSPSNQILIPAMGNITYDFSFKSSVITLTANAGLFNQSDIAGHL
SISSSSVIDALQFKLDGSTSLTRKRGLKLATALSLNNNKFLGGSHDNSISLTKKNLEASM
MTNAKINTPVFKMNFSQELSGNTKSKPTISSGLKVTYDFTTPKHGISAKGGVAHKLALET
L-----TSYLSVETSTKGNIDGAIYTGNSFSGALDHEANTYLHANGVRSSLKLEANSKVD
GLWNSEMKEILAVEASTSRVYAVWEHNGKNFARYTPLFTTTGSQKCKATFELAPWTVSAD
LQIQVTQPNSFLDTASVNQVVLMKVSPTDQKVGWKGEGQIQSLSLRHDMQLSNEKSNAKF
DISGSLEGYMDFLKRINCAISKKSLWDILKLDVTTVADRKHYLNASASFIYRKSDDGYFF
PMPVIRLSDGFTFSIPELHLKAPSPVLSTPEFRVPFSTLQVPAYTIDLRNIKIPQTLNIM
PFDVNLPTLPKLRFPRVDVGANYITLEEYKIPYFEVTVPEYQITVSQFTLPKSISLGSFH
VDLDEVANKIADFDLPTITIPEQKIEIPPLKVSLPAGIYIPSFGALTGSLKVASPLYNVT
WRTDLTNKKESFEVSIDSTCSSTLQFLEYDLNVVSNYKYEEGKFVKKTVGSFAHRDLSAN
YIEDLALQGFGTVENTASLDVISPTFADVHVRYQMTDN-MISSTVSSPSAGILGFLVQIE
T-DTLKEKF---YYR-TLSAPQKDIDILKSEI---SFRNSDIIQIKLNWKEDAAK-DLLL
GLKEKVPKMTSAVYKCVNRYYKEHMGLDISDATVIMKNILQNNADKAYMFAARQVDQMD-
-VQLRTAANEASEKYQEMKVKARQLYKRAA-EQAEQIDYQRIKARLLDATVDLMEEYHSK
IRHLIDSVIEFLKTTKFQIPGLSEKYTGEELYLMATEKAAKTADICLSKLQEYFDALIAA
INELE----------VRVPASETILR-------------GRNVLDQIKEMLKHLQEKIRQ
TFVTLQEADF-AGKLNQLKQVV-QKTFQKAGNMVRSLQSKNFEDIKVQMQQLYKDAMASD
YAHKLRSLAENVKKYISQMK----NFSQKTLQKVSENLQQLVLYIKALREEYFDPTTLGW
SVKYYEVEDKVLGLLKNLMDTLVIWYNEYAKDLSDLVTRLTDQVRELVENYRQEYYDLIT
DVEGKGRQKVMELSSAAQEKIRYWSAVAKRKINEHNR

PF12491 // ENSGT00590000083139_0_Domain_6 (4658, 4715)

QVKAKLQEIYGQLSDSQEKLINV
AKMLIDLTVEKYSTFMKYIFELLRWFEQ-ATADSIKPYIAVREGELRIDVP--FDWEYIN
QMPQKSREALRNKVELTRAL---IQQGV----------------------EQGTRKWEEM
QAFIDEQLATEQLS---------------------FQQIVENIQKRMKT-----------
------------------------------------------------------------
------------------------------------------------------------
--------------------------

-----------------------------------------------MGPPRSALL----
ALLALPALLLLLA-GARAGECSYFCY---VADVF-LPTLGDATR

PF01347 // ENSGT00590000083139_0_Domain_0 (105, 673)

FKHLRKYTYNYEAESS
SGVPGTADSRSATRINCKVELEVPQPCSFILKTSQCTLKEVYGFNPEGKALLKKTKNSEE
FAAAMSRYEL-KLAIPEGKRVFLYPEKDEPTYILNIKRGIISALLVPPETEEAEQVL---
FLDTVYGNCSTHFTVKTRKSNVATEISTERD----LGQCDRFKPIRTGISPLALIKGMTR
PLSTLISSSQSC-QYTLDAKRKHVAEAICKEQHLFLPFSYKNKYGMVAQVTQTLKLEDTP
--KINSRFFGEG-TKKMGLAFESTKSTSPPKQ-AEAVLKTLQELKKLTISEQNTQRANLF
NKLVTELRGLSDEAVTSLLPQLIEVSS--PITLQALVQCGQPQCSTHILQWLKRVHANPL
LIDVVTYLVALIPEPSAQQLREIFNMARDQRSRATLYALSHAVNNYHK-TNPTGTQEL-L
DIANYLMEQIQDDCTGDEDYTYLILRVIGNMGQTMEQLTPELKSSILKCVQSTKPSLMIQ
KAAIQALRKMEPKDKDQEVLLQTFLGDASPGDKRLAAYLMLMRSPSQADINKIVQLLPWE
QNEQVKNFVASH

ENSGT00590000083139_0_Linker_0_3 (673, 709)

IANILNSEELDIQDLKKLVKEALKESQ-LPTVMDFR

PF09172 // ENSGT00590000083139_0_Domain_3 (709, 1017)

KFSRNYQLYKSV
SLPSLD-PASAKIEGNLIFDPNNYLPKESMLKTTLTAFGFASADLIEIGLEGKGFEPTLE
ALFGKQGFFPDSVNKALYWVNGQVPDGVSKVLVDHFGYTKDDKREQDMVNGMMLSVEKLI
KDLKSKEVPEARAYLRILGEELGFARLHDLQLLGKLLLMGARTLQGIPQMIG-EVIRKGS
KNDFFLHYIFMENAFELPTGAGLQLQISSSGVIAPGAKAGVKLEVA-NMQAELVAKPSVS
VEFVTNMGIIIPDFARSGVQMNTNFFHESGLEAHVALKAGQLKFIIPSPKRPVKLL

ENSGT00590000083139_0_Linker_3_5 (1017, 1044)

SGGN
TLHLVSTT----KTEVIPPLIEN

PF06448 // ENSGT00590000083139_0_Domain_5 (1044, 1156)

RQSWSVCKQVFPGLNYCTSG-AYSNASSTDSASYYPL
TGDSRLELELRPTGEIEQYSVSATYELQREDRALVDTLKFVTQAEGAKQTEATMTFKYNR
QSMTLSSEVQIPDFD

ENSGT00590000083139_0_Linker_5_6 (1156, 4658)

VDLGTILRVNDESTEGKTSYRLTLDIQNKKITEVALMGHLSCDTK
EERKIKGVISIPRLQAEARSEILAHWSPAKLLLQMDSS--ATAYGSTVSKRVAWHYDEEK
IELEWNTGTNVDTKKMTSNFPV----DLSDYPKSLHMYANRLLDHSVPQTDMTFRHVGSK
LIVAMSSWLQKASGSLPYTQTLQDHLNSLKEFNLQNMGLPDFHIPENLFLKSDGRVKYTL
NKNSLKIEIPLPFGGKSSRDLKMLETVRTPALHFKSVGFHLPSREFQVPTFTIPKLYQLQ
VPLLGVLDLSTNVYSNLYNWSASYSGGNTST-D--HFSLRARYHMKADSVVDLLSYNVQG
SGETTYDHKNTFTLSCDGSLRHKF-LDSNIKFSHVEKLGNNPVSKGL---LIFDASSSWG
PQMSASVHLDSKKKQHLFVKEVKIDGQFRVSSFYAKGTYGLSCQRDPNTGRLNGESNLRF
NSSYLQGTNQITGRYEDGTLSLTSTSDLQSGIIKNTASLKYENYELTLKSDTNGKYKNFA
TSNKMDMTFSKQNALLRSEYQADYESLRFFSLLSGSLNSHGLELNADILGTDKINSGAHK
ATLRIGQDGISTSATTNLKYSLLVLENELNAELGLSGASMKLTTNGRFKEHNAKFSLDGK
AALTELSLGSAYQAMILGVDSKNIFNFKISQEGLKLSNDMMGSYAEMKFDHTNNLNIAGL
TLDFSSKLDNIYSSDKFYKQTVNLQLQPYSLVTTLNSDLKYNALDLTNNGKLRLEPLKLH
VAGNLKGAYQNNEIKHIYAISSAALS-ASYKADT---VAKVQGVEFSHRLNTDIAGLASA
IDMSTNYNSDSLHFSNVFRSVMAPFTMTIDAHTNGNGKLALWGEHTGQLYSKFLLKAEPL
AFTFSHDYKGSTNHHLVSRKSISAALEHKVSALLTPAEQTGTWKLKTQFNNNEYSQDLDA
YNTKDKIGVELTGRTLADLTLLDSPIKVPLLLSEPINIIDALEMRDAIEKPQEFTIVAFV
KYDKNQDVHSINLPFFETLQEYFERNRQTIIVVLENVQRDLKHINIDQFVRKYRAALGKL
PQQANDYLNSFNWERQVSRAKEKLTALTKKYRITENDIQIALDDAKINFNEKLSQLQTYM
IQFDQYIKDNYDLHDLKIAIANIIDEIIEKLKSLDEHYHIRVNLVKTIHDLHLFIENIHF
NKSGSSTASWIQNVDTKYQIRIQIQEKLQQLKRHIQNIDIQHLAGKLKQHVEAIDVTVLL
DQSGTTISFERINDVLEHVKHFVINLIGDFEVAEKINAFRAKVHELIERYEVDQQIQVLM
DKLVELAHQYKLKETIQKLSNVLQKVKIKDYFEKLVGFIDDAVKKLNELSFKTFIEDVNK
FLDMLIKKLKSFDYHQFVDETNDKIREVTQRLNGEIQALELPQKAEAL-KLFLEETKATV
EVYLESLQDTKITLIINWLQEALSSASLAHMKAKFRETLEDTRDRMYQMDIQQELQRYLS
LVGQVYSTLVTYISDWWTLAAKNLTDFAEQYSIQDWAKRVKALVEQGFTVPEIKTILGTM
PAFEVSLQALQKATFQTPDFIVPLTDLRIPSVQIHFKDLKNIKIPSRFSTPEFTILNTFH
IPSFTIDFVEMKVKIIRTIDQMLNSELQWPVPDVYLRDLKVEDIPLARITLPDFHLPEIA
IPEFIIPTLNLNDFQVPDLHIPEFQLPHISHTIEVPTFGKLYSILKIQSPLFTLDANADI
RNGTT-SANEAGIAASITAKGESKLEVLNFDFQANAQLSNPKI--NPLALKESVKFSSKY
LRTEHGSEMLFFGNAIEGKSSTVASLHTEKNTLELSNGVIVKINNQLTLDSNTKYFHKLN
IPKLDFSSQADLRNEIKTLLEAGHIAWTSSGKGSWKWACPRFSDEGTHESQISFTIEGPL
TSFGLSNKINSKHLRVSQNLVYESGSLNFSKLEIQSQVDSQHVGHSVLTAKGTALFGEGK
AEFTGRHDAHLNGKVIGTLKNSLFFSAQPFEITASTNNEGNLKVSFPLRLTGKIDFLNNY
ALFLSPSAQQASWQVSARFNQYKYNQNFSAGNNENIMEAHVGINGEANLDFLNIPLTIPE
MH--LPYTIITTPP-LKDFSLWEKTGLKEFLKTTKQSFDLSVKAQYKKNKHRHSITNPLA
VLYEFTSQSIKPFDRHFEKNRNNALDFVTKSYNETKIKFDKYKAEKSHDELPRTFQIPGY
TVPV---VNVEVSPFTIEMSAFGYVFPKAVSMPSFTILGSDIRVPSYTLILP-SLELPVL
HVPRNL-KLSLPDFKELYTISHIFIPAMGNITYDFSFKSSVITLNTNAELFNQSDIVAHL
LSSSSSVIDALQYKLEGTTRLTRKRGLKLATALSLS-NKFVEGSHNSTVSLTTKYMEASV
ATTAKAQIPILRMNFKQELNGNTKAKPTVSSSMEFKYDFNSSMLYSTAKGAVDHKLSLES
L-----TSYFSIESSTKGDVKGSVLS-REYSGTIASEANTYLNSKSTRSSVKLQGTSKID
DIWNLEVKENFAGEATLQRIYSLWEHSTKNHLQLEGLFFTNGEHTSKATLELSPWEMSAL
VQVHASQPSSFHDFPHLGQEVALNANTKNQKIRWKNEVRIHSGSFQSHVELSNDQEKAHL
DIAGSLEGHLRFLKNIILPVYDKSLWDFLKLDVTTSIGRRQRLRVSTAFVYTKNPNGYSF
SIPVKVLADKFI--IPGLKLNDLNSVLVMPTFHVPFTDLQVPSYKLDFREIKIYKKLRTS
SFALNLPTLPEVKFPEVDVLTKYSQSEDSLIPFFEITVPESQLTVSQFTLPKSVSDGIAA
LDLNAVANKIADFELPTIIMPEQTIEIPSIKFSVPAGIVIPSFQALTAHFEVDSPLYNAT
WSASLKNKADCVETVLDSTCSSTVQFLEYELNVVGTHKIEDGMLASKTKGTFAHRDFSAE
YEEDGKYEGLQEWEGKAYLNIKSPAFTDLHLRYQKDKK-GISTSAASPAIGTVGMDMDED
D-DFSKWNF---YYS-PQSSPDKKLTIFKTELR--VRESDEEIQIKVNWEEEAAS-GLLT
SLKDNVPKATGALYDYVNKYHWEHTGLTLREASSKLRRNLQNNAEWVYQGAIRQIDDID-
-VRFQKAASGTTGTYQEWKDKAQNLYQELL-TQEGQANFQGLKDKVFDGLVRVTQEFHMK
VKHLIDSLIDFLNFPRFQFPGKPGIYTREELCTMFIREVGTVLSQVYSKVHNGSEILFSY
FQDLV----------ITLPFELRKHK---------LIEVISMYRELLK----DLSKEAQE
VFKAIQSLKT-TEVLRNLQELL-QFIFQLIEDNIKQLKEMKFTYLINYIQDEINTIFNDY
IPYVFKLLKENLCLNLHKFN----EFIQNELQEASQELQQIHQYIMALREEYFDPSIVGW
TVKYYELEEKIVSLIKNLLVSLKDFHSEYIVSASDFTSQLSSQVEQFLHRNILEYLSILT
DPDGKGKEKIAELSATAQEIIKSQAIATKKIISDYHQ

PF12491 // ENSGT00590000083139_0_Domain_6 (4658, 4716)

QFRYKLQDFSDQLSDYYEKFIAE
SKRLIDLSIQNYHTFLIYIKELLKKLQS-TTV--MNPYMKLAPGELTIIL----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------

------------------------------------------------------------
----------------------------------------DATR

PF01347 // ENSGT00590000083139_0_Domain_0 (105, 674)

FKHLKKYVYSYEAESS
TGVPGTADSRSVTKINCKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXX-XXXHELRLTTPEGRPVLLYPEKDEPKHILNIKRGIISALLVPLETEEAKRVL---
LLDTVYGNCSSDFTVKTKKGNVATEVSIERN----LEACDHFKPITTSVSPLAFIQGMVR
PLSTLISSSQSC-QYSLDHKRKHVSEATCKEQHLFLPFSYXXXXXXXXXXXXXXXXXX-X
--XXXXXXXXXXXAQGVSLAFESTKSTSPPKQ-AEAVLKTLQELQKLSISEQNAQRANLF
NKLVTELRGLSDEAVASLLPKLTEVSX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXX------X----XXXX---XX-XX--XXXXXX--XXXX--X----XXX------
XXXX--XXXXXXXXXXXXX----------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXLRKMALTEEVRGVLLQAFLSGASPADKRLAAYLMLMRDPSQSDINRIARLLLRE
QNDQVKNFVASHI

ENSGT00590000083139_0_Linker_0_3 (674, 709)

ANILNSEESNLKDLKKLVEEALKGSQ-LPTPMDFK

PF09172 // ENSGT00590000083139_0_Domain_3 (709, 1025)

KFSRNYQLVKSV
SLPSLD-PVSAKIEGNLIFDPNNYLPKESMLKATLNIFGFAPGDLFEIG-EGKGFEPTIE
ALFGKKGFFPDSVNKALYWADGQVPDHXXXXXXXXXXXXXXXXXXXDMVNGIMLSVEKLI
KDLKSSEVPEARAYLRILGEELGFVRLQDLQFLGRLLLSAARSLQGLPQMIG-EAIRKGS
KNDLFLHYIFMDNAFELPTGAGIQLQVSSSGVITPGIKAGVKLELA-NMQAELVTKPSVS
LEFVMHMGTIIPDFARNGVQMNTNLFHESGLEARVALRAGQLKVIVPSPKRPVKLFSVXX
XXXX

ENSGT00590000083139_0_Linker_3_5 (1025, 1058)

XXXXXXXXXXXXXXXXXXXXXXX----XXXXXX

PF06448 // ENSGT00590000083139_0_Domain_5 (1058, 1157)

XXXXXX-XXXXXXXXXXXXXXXX
XXXXXFELELKPTGEVEQYTASATYGLQREGRALVDTLKFLAQAEGEKQTEASMMFKYNR
QSMTLSSEMQIPDFGVDFGTILRVSDESVKEKKSXXXXXXXXXXXXXXXXXXXXXXFDGK
EEGKIKGVISVPRLQAEVRSEILTQWFPTKLLLQMDSS--ATAYGSTISKKVVWRHDEEK
IEFEWKTGTNVDTKKVASNFPV----DLSDYPRSLHAYTNSLLDYRVPQTSMT-RHMGSK
LIVATNTWLQKVSGHLPYAKVLQDHLSGLEELNLQRMGLPDFHIPQNLFLKSDGRVRYTS
NKHSVQIDIPLPLGNSTTXXXXXXXX-XXXXXXXXXXXXXXPAREFQSPAFTIPKLYQLK
VPLLGVLDLSTNVYSNLYNWSF-YTGGNTSTD---HFSILARYRVKADSVVDLL-YSVQG
SGETTYDRRNVFTLSCDGSLHHKF-LDSNIKFSHVEKRGNSSASKSL---LTFDTSSAWG
PQMSASVHLDSKKKQHLYVKEVKVDGQFRVSSFYAKGTYGLSYQRDTRTGQIDGESNLMF
NSSYVHGTNRITGRYEDGRLSLTSTSDLQDGIIKQAASLKYENYELTLKSDTNGKYEDFA
TSNKLDLTFSEQNALLRSEYXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXL
SLDFSSKLDNIYSSDKFYKQNFNLLLQPYSLVTTLNNDLKYSSLDLTNNGKLRLEPLKLN
VGGNIKGAYQNDEIKHIYTISYADLS-ASYKADT---VAKVQGSEFSHRLSTDIAGLASA
IDISTNYNSDSLHFSNVFHSVMAPFTMTVDAHTNGNGKLVLWGEHTGQLYSKFLLKAEPL
ALTFSHDYKGSTGHRLMSSQSISTVLDHKVNVLLTPAEQTG-AKLKTQLNQNEYSQDLDA
YTKDKSV----LRGRLADLTVLDVPIKVPFLLSKPVNLIDTLLMRDVVDQPQEFTAFASV
KYDKNQDVHTINLPFLKILPAYFERNQKAIIALLESVQKKMKHINIDQFVRKYKAALDKL
PQQVNDYLSTLNWEGQVTNAKKKLTAFTKNFKITADDLQIILDDAKINFNDKLSQLQANV
IQFDQYIKDNYDLHDFKAAIAKIIDRIIEKLKILDEHYHIHVNLVKAIHNLYVLIEKIDF
NQIGNSSASWIQNVDTKYQIRIQIQEKLQQIETQIQNIDIQHLAQKLKQQVDAINVRVLL
DQLRTAIPIQRIKDFIEHLKYFVINVIEDFEVTEKINVFNAKVSELIKKYEVDQRVQVLM
DKSVQLAHQYKLKETVRKLSNIVKQVDIKYYFEKSFGLIDDAVKKLKAMNFEKFIEEVNR
FLDTLVKKLRSFDYNQFVDGTNSKIREVTQRINGEIRALELPQKAEAV-KLFAEEVKAVA
SEYLENLKDTKISSLLDWLHDALSSAPLKDVKAKFQETLEDVRERIYQMDIQQELQRYLS
LISQAYGTLVTYISDWWMLAAKNLTDFAQQYSFQDWAEKLKALVEQGFTFPEIQTIFGTM
PAFKVSLRALQEATFQTPDFIVPLTDLRIPSVQINFKKLKDIKIPPTFTTPEFTVLATFH
VPSFTIDLVEMKVKIIRTIDQMLNSELQWPLPEVYLRDLKVHETLLARITLPNFYVPEVT
IPEIVIPNLNLKDFQVPDLHIPEFQLPRISHTIEVPTFGKLHGTLKIQSPLMTLDTTAGI
QNVTT-SANKAEIVASITAKGQSKFEVLTFDFQANAQLSAPEI--NPLVMKESVKFSSKY
LRTEHESEALILGSTLTGKSNTVASLHTEKNTLELSNSVLVKISKQFTLDSSTKYVHTLN
IPTLDFSSQADLRNEIKTLLEAGHLSWASSGMGSWKWASPKFSDEGTHESQVSLTVEGPV
ASFGFSNKINSKHLRVNQNMIHESGFLNFSKFEIQSQVDSQHVGHSVLTAKGAALLGDMK
AEVTGTHEAHLAGKVTGTLKNSLFFLAQPFEITASTNNEGNLKVSFPLKLSGKIDFLNNY
ALSLGPRVQQASWQASGRFNQYKYNQNFSAGNNENSMEAHIGMNGEANLDFLNTPLTIPE
MT--LPYTSLTTPQ-LKDFSIWEKTGLKKFLRTTGQSFDLTVKAQYKKNKDKHSIPIPLD
VIYDFISQNINSFNRHFEKGRDSALDFLTKSYNEAKTKVEKYKVETSLNELPRTFRIPGY
TIPV---LNIEVTPLTVEMLAFGYVIPKEISTPRLTIPGSDLYVPSYTLVLP-SLELPAL
HVPQNFRKL-LPDFKFLSNPDNVFIPAMGNITCDFSFKSTVFTLNTNAGLYNQSDIVAHF
LSSSSSIFDALQFKLEGTSSLTRKRGLKLATALSL-NNKFVEGSHDSTISLNKKNMETSV
TTTAKVQSPILRMNFKQELNGNTKSKPTVSSSIELKYDFNSPKLHSTAKGAVEHKLSLET
L-----TSYFSIESSTKGDVKGSVLS-QEYSGIIASQASTYLNSKGSRSSVELQGASKVD
GIWNFEVKENFAGEATLQRIYAIWERNMINRLQLEGLLLTNGEHTSKATLELSPWKMSAL
VQVRASQPSSLLDLPYLGQELALNVNMGAQKASWKSEVQVLSGSLQNNVQLSNDQQEVRL
DIAGSLEGYLRFLKEIVLPVYDKSLWDLLKLNVTTSIHKRQYLRASTAFVYTKNPDGYSL
SFPVQELPDKFI--IPRLKPKDPDSGLATPTFQVPFTDLQVPSYTLDFSEIKIYKKLTTP
PFTLNIRTLPKVKFPKVHVFTKYSEPEGSPVPLFEITVPEFQLTLSQFSLPKSISVGSNV
VDSNKLAKKIADFDLPTISMPEQTIEIPSIKLSVPAGVFIPFFGALTARLEVDSPLYKAT
WSAGLKNKADNVETFLNSTCSSTMQFLEYGLNVVATHRIEDGALVCETIGTFSHRDFNVD
YKEDSKYQGLQDWKTDARLDVTSPVFTDVHLRYQENDT-HLFYSAASPATGTVGFYLEDS
D-DIFIWSF---YYQ-PQXXXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXX-XXXX
XXXXNVPKATGALYDYVNKYHQEYTGLDLRDASSRLRRSLQ-----------RQVDEMA-
-VELQRAVNSTTGTYQQWEDKAQSLYQELL-AQEGQINFQRCMDKMYNDSVQYFQEFCGT
VMKLFDSLIDYLRNTRFHLPGGAETYTGDELCNMAIREVVNTLSQVNSKIHDGLEILSSY
FQDLE----------IKLPFYSRSHK---------LIDVFLGIVETLKFLSQEV----QK
AFNELQSVKN-TEMLTYLQNII-LSFLQDIEQGIKHLKEKTFLYLNNDIKSGIITV----
FGEHIPYVFRLLKENYDKFN----GIIQSKLQDASQELHQLYQYIKALREEYFDPSMVGW
TVKYYEVEEKIITLFKNLLVFLKDFHSKYTSRAAGFASQLSNQVEEFVRKNIQEYLSILI
DAEGKGKEKIAELSSTAQEIIKSQATATKEMISDYHQQLRYMLQDFSDQLADCYEKFIAG
SKRLIDLSIQSYRT-LRYVTELLEKVQS-TAVS--GMN----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------

PF01347 // ENSGT00590000083139_0_Domain_0 (188, 674)

YEL-RLAVPGGKQVVLYPEKGEPKHILNIKRGIVSALLVPPETEEDTRVL---
FLDTVYGNCSSDF-VKSRKGSTATEIS--KE----LEKCEHFQPASTGVSPLALIQGLSR
PLSTLINSNQSC-QYTLDPKRKHVSEATCQEQHQLRPFSDKTKYGMMAQVTQTLKLEDTP
--KINSRFFDEG-TEEVGLAFESTRSTSPPKE-AEAVLKTLQDLQLLHVTDQNFLRAQLF
NQLVTELRGLDDKAVSDLLPKLMDVSS--PITLQALIQCGQSPCYTHVLRWLRSESANPL
LVDVATYLVALIPEPSAQALQEIFTTAKEQQSRATLYSLSHVVNNFHK-ANPTVTRDL-Q
AVADYLSEQIREDCSGDEEHIYLILRVIGNIGRTMEQVTPRLKSSVLKCIKSPEPSLLIQ
KAAIQALRKMELNDEVRDALLQIFLNHTSPGEKRLAAYLMLMRSPSQSDVNEIIQLLPQE
QNEQVKNFVASHI

ENSGT00590000083139_0_Linker_0_3 (674, 709)

ANILKSEELYTQDLKELVGKALEESQ-LPTLMDFT

PF09172 // ENSGT00590000083139_0_Domain_3 (709, 1025)

KFSRNYHLSKSF
SLPSLD-SVSAKIEGNLIFDPKNYLPKESMLKTTLAVLGVAPTDLFEIGLEGTGFEPTVE
ALFGNQGFFPDSVNRALYWVDGQVPDPVSKVLVDHFGYTKDEKHEQDMVKGIMLNVQNLI
KDLKSKEFPEARAYLQILGEELGFVRLHDLQLLGRLLLNGVDSLRGIPQMIG-ETLRKGS
RNDLFLHYIFMDNAFELPTGLGLQLHVSSSGIITPGVKAGFRLEVA-NMQMELVAKPSVS
LEFVTSMSIILPEFAVSGVQRNTNFFQESGLEARVALKAKQLKFIIPPPEKPIRLFSFSN
TLRL

ENSGT00590000083139_0_Linker_3_5 (1025, 1041)

VSTT----KTXXXXXL

PF06448 // ENSGT00590000083139_0_Domain_5 (1041, 1157)

VFNKESWSTCKPFFPGLNYCIKG-DYSNTSSTDSALDYPL
TRDTSFVLELKPTGAVRQYSASATYELQREGEALVDTLKLVTQAEDLQENGIFVTFRYNR
QKTTLSSEIEIPDFNVNLGTILRVSDESSEKQKSYKLTLDMQNNKITEITLIGHLSCNRK
EEGKIKGVISIPRLQAEARSEIHTLWSPTKLLLQIDSS--ATAYGSTISKKVAWRYEEEK
LEFEWNAGTNVDTKKAASNFPV----DLSDYPKSLQMYASSVLDQRVPQTDMTFRHMGSK
LIVETHTLLQSISKNLPYTQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXESDGRVKYTL
NKNSMEIDIPLPFGGKSSKDLKMLETIRTPGVNLKSVGVYMPPREYQVPTFTIPELYQLR
IPLVGVLDLSTNIYSNLYNWSASYTGGNTSK-D--HLSLQSQYHIKATSVVDLLSYSVRG
SGA-TYDHKDTV-LAC-NSLHHKF-LDSXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXTREKKHHLYIKGTKIDGQFRVSSLYGNGEYGLTYQRDPTTGQLLGESNLKF
NSTYIQGNNHVTGLYKDGLFTLTSTSDLQDGLIKNSASLKYENYELTVNSDTSGKYEGFV
TSNKVDLTFSKQNVLLRSEYQADYKLLRFFTLLSGSLTSQGLELNADILGSGTAHRGAHK
ATLKIGQDGISSSALTNVMFSPLVLENEMNAGLSLSGASMKLTANGRYREHNAMFNLDGK
AALTEISLGSVYQAMILDVDSKNVFSFKINREGLKLSNDMMGSFAEMKLDHSNKLNIAGL
SLDFSSKLDNIYSSNKFYKQNFNLQLQPLSLVTSLNNDLKFNALNLTNLGKLRLEPLKLS
MSGFVRGAYQNNEAKHTYT-SYAXXX-XXXXXXX---XXXXXDTEFSHQFNTDLAGLAFA
LDTSTNYNSEALHFSNVFHSAMAPFKMAISAHTNGDGKLVLWGNHTGKLYNKFLFKAEPL
ALTLTHDFKGSTSHHHVSGKSTSTALDHKVGVLLTLSEQTSTWKFKTQLNRNEYSQDIDV
YNTEDKVGAEFNGQALADFTMLDSPIEVPFLLREPVNVIDALELRDATDQPQEFAIVASV
KYDKNQDVHTINLPFLKDMPEYFEKNRVAMVTALETIQRQLRHTNIDQFMRNYREAMIKL
PQQVNDYIDASNWEKHVSQAKEKLAVFTKNYGITENDLKIALNNAKINLNEMLFQLQTYV
IQFDQYIKDNYDLHDLKITIAKIIDQIIEKLKILDEHYHIKVNFIKVINDIYIFIEKIDL
NKIGNSIASWVQTMDTKYQIRIQIQNKLQQLKTQIQNIEIQLFAEKLKQYIETVDVRVLW
DWLRATIPFQ-IKEIIEHIKYCVKSLIEGSKVTEKINAFRVMFHKLIESFEIDRHIQVLI
YKLIELSHQYKLKETVQKLXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXMKKIIRTIDQMLSSELRWPVPEVYLRDLKGVDIILACITLPNITLPEFR
VPEFIIPNLHLRDYQVPEFHIPEFQLPRLSHKIEVPAFGKLYSILKIKSPLFTLDLNANI
QNITS-SVNNSEIAASITAKGVSQLELLNFHFQANAQLLDPKM--NPLVLKEFARFSNKY
LKTEHDSEVQFGGNAIKGKSNTVAALHTDKNTLEFRNGLLLKINNQLTLESSTKYSHKLN
FPKLEFSSQADLRNEIKTLLEVGHIDWTSSGTGSWKWACPRFSDEGTQGTQISFTLEGPI
SSFGLLNEIRSKHLKVNQSLSYECAFFNFSKFEIQSQVESQHVGRSVLTAKGTVLLGEGE
AAVTGNHDAHLNGKVSGTLKNSLSFSARPFEVTASTNNEGNLKVSFPLKLTGKIDFLNNY
ALFLNPSAQQTSWQASVRFNQYKYNQNFSAGNNENSIDAHVGMNGEANLDFLNIPLTIPE
MT--LPYTMLKTPQ-VKNFSIWEKTGLKKFLKTTKQSFDLSVKTQYKKNKDTYPIPHPLA
MFYVYFNHNINSFIRQVEKVREKTFGFIIESYNEAKVKYDEYNVEKSDTKNPRTFQIPGY
TIPV---VNIEASPFTIEMFPFGYVIPRAINTPTFTILSSGFSVPSYTLVLP-IPELPTL
HVPKF-LELSLPEFKELSIPRNIFIPALGNITYDFSFKSSVITLNANAGLYNQSDIVAHV
ITSSSSVIDALQYKLEGTSSLTRKRGLKLATALSLS-NEYVEGKHDSTISLAKKNMEASV
ATTAKIHLPILTMNFTQELNGNTKSKHAISSFIELKYNFNSPCLYSTATGTVDHKFLLEN
P-----TSYFSIESSTKGDINGSVLS-REYLGTIASEFSTYFNSKSTRSAVKLQGTSKVD
GILNFEVNETFAGEASFRRIYAIWEHNAKNQLQLMDLFLTSGNHASKATLELSPWKMTTL
VQIRASQPNSLLDIKSLVQEVSLKADTQNQKSHWKSEVQIHSGRLYNNVQLSNDPKEMRL
SMAGSLEGYLGFLSGFVLPVYDKSLWDLLKLNISSNINRKQYLHTSTALVYNKAPNIRLF
SLPVQELVNKFV--IPGLKQNNLNSVIVTPTFRIPFTNLQFPSYTLNLSQIEVYKNLSSL
PFDLNIPLLPKLTFPKVDVLTKYFQPEDSSVPFFEITVPESRLTMSKFTLPKRVSFGIIN
WDLDEATRKIADFELPSTIMPEQTIEIPPIKFSIPAGIFIPSFGTFTARFMVASPLYSAN
WVSGLKNKVDHVETFLESTCSSSLQFLEYDLNVVATHRIENGALVCRMNGTFAHRDFKAE
YKEDGKYQGLGDWIVDVHLDITSPTFTDLHLRYQSGER-GVSSSVASPAIGTVTIDVDDN
D-NILKWHI---YYQ-PQSTPNKTLSIFRYH-------KSENSQIKVNWEEAS---KLLR
SIKDNVPRATGVLYDCVNGYHQNYTGLDLRDASLKVKRSLQKTAEWAYLSAKRQIDEAD-
-TRLQRVARSTTGIYQQWQDKTQNLYQDLL-ALEGRADFQKLHSTLFDGLIGAAQKYSAT
VKYVIESFINFLKFTRFQIPGRSGMYTGDELCTMAVREIAKVLSWAHSEILSGLKLVFSY
FQDLMVKSELIEFLQIKW-----------------------EWGELLM----HLSQRIQK
VLSDLQSMKA-TEMLSGLQRFL-HHVCQEMEGKIKDLKEKKITSLISSIPQEISLIFNKH
IPYLFESLKENLCFTFNKLVHRSREIVQDKFKEVPQEI-QHHKFIKAHRKEYFDPHMVIW
MVKYHDLEGKTINLIKKLPSTHEVFLF--KCTVNNFASQLPSQVEQVVQKVIQEYVDILA
S-IGKEKEKTEEISIIYQEI--NWIAEIKETMSDCH-KFRYKQKNFSDHQSDHCEKFIPK
SLRLTDQSIQIYHVYLSCHTELLIEQQT-VLVNDMRSYIKVALGEITTL-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------

PF01347 // ENSGT00590000083139_0_Domain_0 (187, 674)

RHEL-KFSTQDGTKVKLYPKKEEPLNVLNLKRGIISALLAPTETEENIKTI---
SMDTVYGKCNSEVEFKSRRGSVAEDISINRN----LKACDNFSPIRDYVSPVAIVKGLLF
PLSCKPYNPPTLSQIILEIKLKQLSDAMKTTSHFPLLIRYKDFK-------FHLFLQNVQ
LLNFKNSSIRQYELEEKGLALESTDAKFSR--QDDAVLKILQELQKLTVSQQNQQRAKLF
YRFVSGLRSLHNSTLGSLVPKMMETSS--SITIQALIQCGTPECYSAVLQILRTGNVNPL
VVDLVTYTLGLLPSPTPKRIREMLNMAQYQPSRASFYGLSHAVTKFYN-EKMIVTEEI-T
DVADFMVSLLGTECSGDAELTYLTLRAIGNMGAVMEKAKPSLKSSLKTCIRNQAASLSVQ
KAAIQAFRKMTITEEDRSALLREFQEGDAPTDKRLATYLLLMKNPSPGDLTKIMRILTRE
KNEQVKSFVASHI

ENSGT00590000083139_0_Linker_0_3 (674, 709)

ANILDSDEVGIEDLKSHVEEALKGNE-VPTAKDFR

PF09172 // ENSGT00590000083139_0_Domain_3 (709, 869)

KFSQNYQVSKRV
SVPGLD-PISAKVEGNVIFDPNRYVPKETMLKTTLNVYGFGPSDIFELGLDGKGFEPTLE
ALFGEKGFFPDTASKALYWVDGKVPEQVSKALFDYFGYSHDGKQDQEITKAIILNLEKLI
KELSKKEAPEGRAFLRILGEELGYMKLNDFKLLGSVVL----------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------

-----------------------------------------------MGPVQL-------
----------LLL--SLLLSSGVLTQEESPESGN-PECSKDVTR

PF01347 // ENSGT00590000083139_0_Domain_0 (105, 673)

FKPLRKYVYSYEAETS
SGVPGTTDSRSGSKITCKVELEVPQLCRFTLRTMHCSLRETFGVDTEGRAILKKSKNSEE
FANAMSKNEL-KFSIQDGTKVKLYPEKEEPLNVLNLKRGIISALLVPAETVENVKTI---
PMDTVYGKCDSEVEFKSRKGNVAEDISITRY----LKGCDNFSPIRDHVSPIATVKGLNS
PLSSLLKSTQFC-HYNIDAKKRHIRDAVCSEKHLFLPSSYKNRYGIMTEVNQTLKLEDTP
--KITNKNFDGDALEEKGLALERTDAKLLR--QGDAVLKTLQEMQKLAASQENQQRARVF
YRFVSGLRSLHNSTLGSLVPKMMETSS--SITVQALAQCGTPECYSAILQILRTGNVNPL
VADLVTYTLGLLPSPTPQRIREILNMAQYQPSRASFYGLSHSVTKFYN-EKKIVTEEI-A
DVADFMVSLLGTDCSGEDELTYLTLRAIGNMGAVMEKAKPSVKSSLKTCIRNEAASLSVQ
KAAIQAFRKMTITEEDRSALFKAFQELDAPTDKRLASYLLVMKNPSPSDLAKILRVLTKE
KSEQVKSFVASH

ENSGT00590000083139_0_Linker_0_3 (673, 709)

IANILDSKELGIEDLKSRVEEALKGNQ-LPTAKDFR

PF09172 // ENSGT00590000083139_0_Domain_3 (709, 1025)

KFSQNYQISERV
SVPGID-PISAKVEGNVIFDPSSYIPKETMLKTTLHAYGFDPSDVFELGLDGKGFEPTLE
ALFGEKGFFPDTATKALYWVDGKVPEQVSKALFDYFGYSQDGKQEQDIAKGIILNLEKLI
KELSSKEAPEGRAYLRILGEELGYMKLNDFKLLGSLILKSVKTLQTVPEMIA-QAISKGI
DRDLFVHYIFMDNEFELPTGAGLQLKFALSGIATPGARVAAKLHQK-SMQADLIAKPSVA
VEFVTHLGINLPEFAGSGVEMNSNIFHESGIEAHVSVKAGQLKFSIPAPKAPVKLLSISN
TLHL

ENSGT00590000083139_0_Linker_3_5 (1025, 1043)

VSPA----KTEEIPTVIE

PF06448 // ENSGT00590000083139_0_Domain_5 (1043, 1156)

KQTTSTSCKPFIPGLNFCAKV-LYSNSTDTEAVPYFPL
TGESRFEVELVSTGEVKEYSAIANYELQREGNDKIDTLKFAIQAEGVNHHEATLTFRYNR
GKKIFTSDVQIPDVDVDFGTNFRITDESISGKKAYTFVLDINNKKITEVTLSGQIRYAGV
EEAMLRGTISFPRLETELRSEALVNYSPNKAYLQISSA--ATIHGNSISKRVLLRYDAEK
VELEWSSGVSAAVKKLFSAFPV----DFSDYPKTLEKRANDLLDRKVAHTDMTLRHVVSQ
FIVATNTWLQKTSKDVPYSQALQDKLSALQELNIEKLSLPVITIPEELFLKSEGRVRYNF
NKNSFVIDIPLPYAGRSSDEIWVPKTVKTPPLVVESMGISVPSQEYRIPTFTVPKSYPFR
VPLLGKLEVSAGVYSNFYNWTAAYTVTNSTTER--LTSVKATYNTNADCDFELLAYSVKG
SGEASYN-RNGFICAYENHLTHSL-LTSVFKLSGRKSYEPIPFSNYT---LSLTASSTVG
PQLSFSSDIFSENINNMNTNNVKMEGQLEVASVFAKSIYTLSTTYNEKRRVLEGKSNLKL
DSSYLQVTNQMSGRYSDGPFSITSVSDVQNGLLKNTASVKYENSQLKMSSETSGRYRHTA
GANKLEIILSNKMAALRSEYQATYKQIQYFALFAGSLTSQDLVFNTDISLTDQKNRAAHK
SSLNINRYGLASSATTNMQFSPLAMQSEMNAKLDTAGGSMSLSSSGRYGKNNAKFNVGGR
VSLTEITLGSEYQSTVLGMDNKHVLNFRVNTEGLKFSNNLQGSFKDIKLEYTNDLNIPGL
SLTFVSKLDNSFSFDKFHKHVFDLQLQPTSLTAKLNNNLKYTKTEVSNKAELLLKPLNMN
LGGNIRGAHGADEIKHTYTLTCAGLT-ADLKTDT---VANVQGAAVSHRVHLDVAGLSSS
VTMNTNCDSKPLRFSNAVRSTMAPFVITADVHTNANGKLVAVGEHTGDLYSKFLLKVEPL
AFTFSHDYRGSTSHSLKSRGKYTTLLDNKVHMLFTPSEQSSAWKLKSQLNNNVYSQDFSA
YNNAEKIGVELNGKALADLSVMDTSVILPLT-SEEVNLIDVLGLRNSVSEPQEFSISGFV
KYDKNKDMHVISLPVLESLPVYFERLRGTILSTLQALQRYLKSIDMEQHMKKYKANLDKL
SQDINDYVDTLDIKSKISSMKNNFVAFTKDYRITSDDLQMMLEKAMDKLQEILSELQIYL
IEVEQHIKDFYEQYNIKALIAQLLDQIVETMTALDNKYQVRTTVINIIEKLRVFFQQYDL
NKIGSSALAWIKNVDDEYEITAKIHENLELLKIQIQKIDVRSIAENLKRQIKSFDAKECL
EKIKKSLPIEKINDILEQIKDFILNWIEEYELSEKISAFRGHMHKLIVKYEIDKQIYFLI
DRMIELLKTYRIKETVQKLTTYLQNTDVKSCFDKVVAFVDDAVKKVQTFDYEKMIKQVNK
FLDMVIKKLKAFDYDQFVDDTNNKIREVTQKINEELRNLELPQKAEAL-KQYIRDFRSVI
SKYMGQLKDTNLAAIINWLRELIDSTTFANLKVKVNEHLEDLRERISEMDISQELQWCLQ
KISQFYNSVVIYVSDQWNTAFKKITALAEEYDLKNWAENLKQFVEAGFKVPEIRTVVVTI
PAFEVSLRSLREATFRTPEFIVPLTDLRIPSYEINIKRLKDMKIPMKFTTPEFKILNTFQ
IPSFKIDLIEVKLLIVRTIDKFMSAEFQLPSIDVYLKDLKMRDMPFSDISFPEIQMPQFQ
IPELLIPKLNLNELQIPDLKIPEFQLPHIPHTVTVPTFGKLSGAFRVTSPFFTLSTQAEL
RNTTT-SANSPEFVTSISAQTTSKLDFLVFSVIADSRLLAPDM--KQLNLKNAVKVNHRF
LKVDHTNEVVFLGTSVEGEAETRANLHTKKNSIELQNNLMVKLQRKIWMQSGMAYSHRLN
IPQADVSSQADLVNNMTTEVEAGYISFTSAGKGNWKWASPNFSDEGTHDSHATFKIEGPT
ITFSANNRINDKYLKVNQAIRYECHSLLLSTFQIQSEIESQRVGRSILNVGGTGELLGMK
VELTGSHNARLHGRITGTVNNELSFLSHPSEIRLSTNNDGNVKISFPMKLTGKIDFLNNY
GFVLSSSVQQVNWQATGRFNQYRYSHNMSAGSNDDRIEAHIEMNGDANLDFLNIPLSIPQ
FQ--IPYTGIKTPQ-LKDYSLWEQVGLKELLKTTRQSFDLNLKARYEKNKDMHAIPLPLA
KVHEVLNKNILLFNKHFEKGRNAALDFLTKSYNEAKTKLDKYKIQTSLNKVPRTLRIPGY
TIPI---LNIEVSPFTAEMPAFGFTLPKEISTRGFTVPMIGFSVPSYTLVVP-SFELPVL
HIPQDLRTIKLPRFRINNSANSILVPAMGNVTYDFSFKSSVITLTANAGLLNQSDIVGHL
SVSSSSVIEALQFKLDGSTSLTRKRGLKLATALSLSNNKYLGGNHDSTITLLKRIMEASV
ATNIEVDTPVLKINFSQELSGNTKSKPTLSSGLKLTYDFNTPKFGTSAVGEIAHKFALES
L-----TYYISVESSTTGDINGIFYTGNAFSGRLDHEANAYLNANGARSSLKFEAQSKAD
GLWIIEIKELLAVEASTRRIYAVWEHNGKNYARYTSRFTTTGTQRCKATLELAPWDVSAD
LQIQAIQPNPYLGMASVNEVVVVKISPANQKAGWKGEGQIHSLSLSHDMQLSNEKSKAEF
FISGSLEGYMGFLKVIKCPISEKSLWDIMKLDVTTSDDRKQYLNGSASLVYTKSEDGYFF
PIPVDKLTDGFTVTIPGLHLKAPSPVLSTPEFNLPFTTLQVPAYTVDLRNIKIPQTLSTV
PFDVHFPTLPKLRFPKVDVGANYITLEEYKMPFFEVTIPEYQITMSQFTLPKSVSFGSFS
VNLDEVANKIADFEMPTITIPEQKIEVPPLKISLPAGIYIPSFGALTGSFKVVSPLYNVT
WRTDLTNKKDSFEHSIDSTCSSTLQFLEYDLNVVSNYEYKEGVFVVKTTGSFSHRDLSAN
YNENLTLSVFGPLEDTLSLDIISPTFTDVHVRYQENERKS-YGSISSPSAGTLAYVVEVD
D-EIFLARV---YYQ-TQSAPQNDIDILKGEI---SLKEPDQIQMKFNWNEDAAK-DLLL
GLKERVPKMTNAVYGYVNRYHKEHMGLEISAA----------------------------
------------------------------------------------------------
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--------------------------

-MGRGRRPRIPSSVRGGGLRVPVPEEPAGQPGDTRR--SEGAARPVAMGRPRP-------
------ALLPGLLLLL--AVAGAGAQDEVLENAS-PSCPKGATR

PF01347 // ENSGT00590000083139_0_Domain_0 (105, 673)

FKHLRKYVYSYEAESS
TGVPTAADSRSATRINCKVELEVPQLCSFILRTSQCTLKEGSGFNPKGRPSLQKTENSED
FAAAMSRHEL-RLAIPEGKQVLLYPEKEESTHILNIKRGIISALLVPLETEADKQEL---
FLDTVYGNCSSDLTVKTKKANVATEISIERN----LEKCDHFKAVSTGVSPLALIKGMLH
PFSTLISSNQSC-QYTLDPKKKHVSEAICREQHLFLPLSSKSQYGMNAQVTQTLKLEDTP
--KINSRFFEEG-TEVVGLAFERTKSTPPPQQ-AEAIVKTIQELQTLHVSEQNAQRANLF
RKLITELRSLNKEAFTSVLPKLIEVSS--PITLQALIQCGQPQCYTHILQWLRSEKANPL
LIDAVTYLIALMPEPSAERLQEIFSTAKEQQSRATLYALSHTVNNYHK-ANPLVTQDL-L
DVADYLLEQIRDDCTGNQDHTYLILRVIGNIGRTMETVTPRLRSSVLKCIKSTEPSLLIQ
KAAIQALRKMELNDEVREVLLQVFLNDASPGDKRLAAYLMLMRGPSQSDINQIIQLLPRE
QNEQVKNFVASH

ENSGT00590000083139_0_Linker_0_3 (673, 709)

IANILNSEELYIKNLKKSVEEALKGSQ-LPTIMDFS

PF09172 // ENSGT00590000083139_0_Domain_3 (709, 1025)

KFSRNYQLSKSV
SLPSLD-PVSAKIEGNLIFDPNNYLPKESMLKTTLTVFGFAPGDLFEIGLEGKGFEPTLE
ALFGKQGFFPDSVNKALYWVDNQVPDHVSKVLVDHFGYTKDDKREQDMVNGIMLNVKKLI
KDLKSKEFPEARAYLRILGEELGFVRLHDIQLLGKLLLDGVHTLPGIPQMIR-EAIRKGS
VNDLFLHYLFMDNAFELPTGLGLQLQVSSSGVITPGIKAGMKLEIA-NLQMGLVTKPSVS
VEFVTNMGIVIPDFSRTGIQMNTNFFHETGLEMQVALKAGQLKFIVPSPTRPVKLLSGSN
TLYF

ENSGT00590000083139_0_Linker_3_5 (1025, 1042)

VSTD----KTEVVPPLN

PF06448 // ENSGT00590000083139_0_Domain_5 (1042, 1156)

ENRRSWSACKPLFLGLDYCTSG-TYSTVTSLELASYHPL
TRDTRFELELKPTGEVEQYLASVTYELQREAGAPVDTLTFVTQTEGAKLTEATMTFKYNR
QRMTLSSEIQIPDFD

ENSGT00590000083139_0_Linker_5_6 (1156, 4658)

VDLGTVLRVSDESTVEKKSYKLTLDLQNKKITEVTLTGRMSYNKK
EEGKIKGVISVPRLQAEVRSEILTQWSPTKLLLLMDSS--ATAYGSTISKKLVWRYDEEK
IEFEWNTGTNVDTKKAASNFPV----DVSDYPKSLHMYANSLLDHRVPQTDMTFRHMGSK
LIVATNTWIQKASNHLPYVQNWQDQLSGLKELYLQKMGLPEFHIPENLFLKSDGRVKYTL
NKNSMIIEIPLPFGGKSSKDLKMLETIRTPDLNFKSVGFHLPSREFQVPTFTIPKLYQLR
VPLLGVLDLSTNIYSNLYNWSASYTGGNTST-N--HLSLQARYHMKADSVIDLLSYSVQG
SGETTYDRRNSFTLSCDGYLRHRL-LDSTMKFSHVEKIRNNPASKSL---LTFEASSAWG
PQMSASVHLDSKKKHHLYVREAKIDGQLRVSSFYAKGTYGLTYQRDSNTGQLSGESNLRF
NSSYLQGTNQMTGSYEDGVVSLTSTSDLQDGVIKNTAFLRYENYELTLKSDTNGKHEDFA
TSNKVDMTFSRQNALLRSEYQADYKSLRFFTLLSGSLNSHGLELNADILGTDKINSGAHK
ATLRIAQDGLSTSATTNLKYSPLVLQNELNAALGLSGASMKLTANGRFREHNAKFSLDGK
AALTEVSLGSAYQAMILGVDSKNVFNFKISREGLKLSNDMMGSYAEMKLDYTNSLNIAGL
SLDFSSKLDNIYSSDKFYKQNVNVQLQPYSLVTTLNNDLKFNALDLTNSGKLRLEPLKLN
VGGNIKGLYQNNEIKHIYTISYGDLS-ASYKTDT---VAKVQGTEFSHRVNTNMAGLAST
IDISTNYNSDSLHFSNAVHSAMAPFTMTIDAHTNGNGKLSLWGEHSGQLYSKFLLKAEPL
SLTFSHDYKGSTSHHLPLKSSITTALDHKVSALLTPAEQTGTWKLKTRLNENGYSQDFDA
YNNKDKVGVELQGQALADLTLLDYPIKVPFLFSEHTNIIDALGLRDAVDQPQEFRVVASV
KYDKNQDVHTINLPFFETLPEYFEEKRMVIITALETIQRELKLIDVDQFVRKYRTALDEL
PQQVNGYLNALNWERQISSAKEKLTALVENYKITENDLQITLDNTKISLNDKLSQLKTYV
IQFDQYINDNYDLDDFKTAIAKIIDQIIENLKILDEHYHIHVNLVKTIHDVCLFIEKTDF
SRIGSSTAFWIQNVDAKYKIKIQIQEKLKQIKTQIENLDLQHLAEQLKQQVQATDVRVLL
HWLRTIIPFQRIQEIIEHVKYYIINLMKDFEVAEKISALGTMSHELIKMYEVDKHIQVLM
DKSVQLAHQYKLTETVQKLSSVLQQVKIKDHFEKLVTFIDNAIKQLKALSFKKIIEQVNR
SLDLLVKRLRSFDYHQFVNETNNKIHEVTQRLNGEIQALELPQKAKAL-TLFVEDIKAKV
SVHLEHLKGTQINIFFDQLQEALSSTSLIYMKEKFRETLEDTRDRLYQMDIQQEVQRYLS
LISQAYSTLVTFISDWWSLAAKNLTDFAEQYSIQDWAENLKALVERGFTIPEIQTTFGTM
PAFEVSLRALQEATFQTPDFIVPLTDLKVPSIQINFKRLKDIEVPSKFATPEFTVLNTFH
VPSFTIDLVEIKAKIIRTIDQMLHGELQWPVPEVDLRDLIGVDTILASITLPDFHLPEIT
IPELIIPNLDFKDYQVPDLHIPEFQLPSISPTVEVPTFGKLHGLLKIQSPLFTLDANADV
QNVTI-SGNRAEIAASVTAKGESKLEVLNFDFQANAQLSDPEI--NPLIMKQSMRFSSKY
LKTEHESEVLFFGNRIEGKSNTVAGLHTEKNTLELSHGVLVGINNQLTLDSNTKYFHKLN
VPKLDFSSQAELRNEIKTLLGAGQVAWNSSGLGSWKWACHTFSDEGSHESQAGFTMEGPS
ASFGLSNKINSKHLRLSQNLVFESGFFDFAKFEIQSQVESQHVGRSVLAAKGTALLGERK
AEITGNHDAHLNGKVIGNLKNSLFFAAQPFEITASTNNEGNLKVSFPLKLIGKVDFLNNY
ALFLSPSTQQASWQASARFNQYKYHQNFSAGNNENSIEAHIGINGEANLDFLNIPLTIPE
MT--LPYTTLTTPQ-VKDFSLWEKTGLKDFLKTTKQSFDLNVKAQYKKNKDEHIIPIPF-
------------------------------------------------------------
------------------------------------------------------------
---------YAKDFQVLSTPNDIFIPAMGNITYDFSFKSVLITLNTNVGLYNQSDIVAYF
LTSSSSVTDALQYKLEGTSSLTRKRGLKLATALSLS-NKFMEGNHDSTFSLTKKNMEASV
TTSAEVQIPILRMKFKQELNGNTKSKPTVSSSIELMYDLNS-----TATGTINHKLNLES
L-----TSYFYIESSTKGDIKGSVLS-LEYSGTIDSEASTYLNSKSTRSSVKLQGASKVD
GIWNLEVKENFAGEATLQRIYAIWEHNTKNYLQLGGFILSSGEHTSKATLVLSPWKISAF
IQVHESQPHSLLEINYLGQEVSLHANTENQKISWKSEVQVHSQFFQNNIQISNGQEEARL
DIASSLKVSPWFLKDIVLPVYDKSLWDLLKLDVTTSIDTKQDLHASAALVYTKNPNGYHF
SFPLQELADKYI--IPRLKISDLNSSFVIPTFQVPFTDLQVPSYTFDFSEIKIYKKLSTL
PFSLYIPTLPKVKFPQVDVLTKYSEPEDSSVPFFEITMPASQLTVSQFTFPKSFSAHSAV
GYLNEVARKIADVELPAITIPEQTIEIPTLTFSVPAGIFIPFFGGLTAHFGVASPMYSGN
WSAGLKNKGEYVETFLNATCSSTIQFLEYDLNVVGTHKFEDGTFICRTKGTFAHRDISAE
YKEDSKYQGLQDWKKEIHLDITSPAFIDVHLHHQLSKN-SLSSSVTSPAIGTVALDLEEN
N-STLKWNL---YYR-PRSSLDKKLDIFKTEWR--YQESGENRQIKVRWEEEAAS-ELLS
SLKDNVPKATRALYNYANKYHQEHTGLDLGDASLKLRRSLQNSAEWAYQGAMRQIDEAE-
-IELQRIARDTTRTYQQWKDKAQDLYQKLSLAQGDQADLQGLQNDMFDRLIVVTQKYKVL
VSHQIDLLVDFLKSTKFQLPGKAGTYTIDEVCTVVMKKVGQVLSKIYSKIHSGSEILFSY
FQDLMEKSELIKDLEIKIPFESKNVK---------LKNLISEFGSLLE----YLSDKLQD
IFNKLQSLKT-TEMLSDLQNQL-QDTFKDIEEVIPYLKGTEFAYLIDFIQDKINIIFNES
ITYVSELL----SLYLGKFN----EL-EYRLQEASEQLQQYRQYIKDLYKESVDGSVFSW
TTRFYELEEKIICFLENLVGVLKDLHSTYIVSTAMLSSEISNHVEQW-QKDIQEYLSILT
DADGKGKEKIAELSTRAQEKIKSWATAMKEIISDYHQ

PF12491 // ENSGT00590000083139_0_Domain_6 (4658, 4715)

QFRYKLQDFSEQLSEYNEKFITE
SKRLIDLFIQKYHMFLTYITELLKEIQL-TTVNNMIPYITVSPGEFTITF----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------

-----------------------------------------------MGPVQL-------
----------LLL--LLLLSSGVLTQEETPENGN-PGCSKDATR

PF01347 // ENSGT00590000083139_0_Domain_0 (105, 674)

FKHLRKYVYLYEAETS
NGITGTADSRSGSKITCKVELEVPQLCHFILRTMHCSLRETFGVDAEGRSMLKKSKNSED
FANAMSKHEL-KFSIQDGTKVKLYPEKDEPLNVLNLKRGIISALLVPTETVENVKTI---
SMDTVYGKCDTEVEFKSRKGNVAEDISINRN----LKTCDNFSPIRDYVSPIAVVKGLNI
PLSTLLSSTQFC-HYNIDAKKRHIRDVVCSEKHLFLPSSYKNHYGMMTEVNQTLKLEDTP
--KINNRNFDIDELEEKGLALEVADAKFSR--QGDAVLKILQELQKLAASQQNQQRARLF
YKFVSGLRNLHNTTLGSLVPKMMETSS--SFTVQALIQCGTPECYSAILQILRTGNVNPL
VVDLVTYTLALLPSPTPERIQEILNMAQYQPSRASFYGLSHSVTKFYN-EKMIVTEEI-M
NVADFMISLLGTDCSGDAELTYLTLRAIGNMGAVMEKAKPNLKSSLKTCIRNEAASLSVQ
KAAIQAFRKMTITEEDRSALLKVFQ-GDAPADKRLAAYLILMKNPSPSDLTKILRVLTKE
KNEQVKSFVASHI

ENSGT00590000083139_0_Linker_0_3 (674, 709)

ANILDSEEVGIEDLKSRLEEALKGNE-VPTAKDFR

PF09172 // ENSGT00590000083139_0_Domain_3 (709, 1025)

KFSKNYQVSKKV
SVPGVD-PISAKVEGNVIFDPNSYVPKETMLKTTLDIYGFGPSDIFELGLDGKGFEPTLE
ALFGEKGFFPDTASKALYWVDGRVPEQVSRALFDYFGYSQDGKQDQEVMKGIMLNLEKLL
KELSNKEAPEGRAYLRILGEELGYLKLNDFKLLGSMLLKSIKTLQSIPEMIA-QAISKGV
DRDLFVHYMFMDNEFELPTGAGLQLKFALSGIATPGAKVAVKLHQK-SMQAELIAKPSVA
VEFVTHLGINMPEFARSGVEMNSNIFHESGIEAHVSVKAGQLKFSIPAPKTPTKLLSISN
TLHL

ENSGT00590000083139_0_Linker_3_5 (1025, 1041)

VSPT----KTEEIPPL

PF06448 // ENSGT00590000083139_0_Domain_5 (1041, 1157)

IENREFWTSCKPLIAGLNFCTKL-LYSNASATDAAPYYPL
TGETRYEVEIVSTGEVKEYSASANYDLQREGNGLIDTLKFALQAEGVKQHEATLTFKYNR
DRKILTSDVQIPEVDIDFGTNFRISDESTSGKKAYTFVLDFNNKKISEVTLTGQIRYAGM
EEAMLGGTISIPRLQTELRSEALVNYSPSKGYLQMSSS--ATTHGNTISERVLFSYDSEK
VELEWNSGASAAVKRMSSVFPV----DFSDYPKTLEKYANELLDQKVAHTDMTMRHIVSQ
FIVATNTWLQKASKDVPYAQTLHAKLSGLQELSIQKINLPVITIPEELFLTSEGRIKYIF
NKNSFLINIPLPFGGRSSYDIRVPQTVKTPPLVMESIGINVPSQEYRIPAFTVPESYPLL
VPLLGTLEVSTNVYSNYYNWTGAYTLANSSTEK--ASSIRTTYTTNADSVFELLSYNVKG
SGEASYN-RNGFTCAYENHLKHRL-LTSVFKLSRTKSYEPSLVSNCT---VSLMASSTLG
PQLSFSGDIVSEKTNNMNINNVKMEGQLEVASVFARSIYTMSSSYNEKRRVLEGKSNLKL
DSPYLQATNQLSGRYSDDVFSITSVSDVQSGLLKNTASLKYENSQLKMTSETNGRYRQLA
AVNKLELILSKKMAALRSEYQATYKQAQYYALFAGSLNSQDLVFNTDISLTDQRNRAAHK
SSLNVNQYGLASSATTNVQFSPLTMQSEMNAKLDTAGGSMSLSSSGRYGKNNAKFNLGGR
VSLMEVTLGSEYQSTVLGMDNKHVLNFRVNREGLKFSNSLQGSFKEIKLDYSNDLTIPGL
SLMFSSKLDNSFSFDKFHKHGFDLQLQPRSLTAKLSNNIKYTKTEVSNKAELLLELLKLN
LGGNMRAAYGSDEIRHTYTITYADLA-ANFKTDT---VANVQGAAVSHRVNLNIAGLATS
VTMNTNCDSKSLRFSNALRSTMAPFTVTADVHTNGNGKLIAMGEHTGDLYSKFLFKAEPL
AFTFSHDYRGSTSHSFKSRGRYTTQLDNKVHMLFTPSEQSSAWKLKSQLNNNVYSQDLNA
YNDAEKTGVELSGRALADLTVLDTSITLPFT-PEEVNIIDVLGLRGSVSEPQEFSISGSV
KYDKNKDMHVINLPLLEHLPVYFEQIRGAMLTSLQAVQSYLKNIDIDQYMREYKATLDKL
PQHLNDYVEKLDLKGRVSTMKTNLIAFTKDYRITSDDLQIMLEKALENLQEILLQLQVYL
IQLEQYIKDNFEQFDIKALIAQLLDQVVEKITALDNKYNIRMTIVDTLQRLQFFFQ-DYP
SKIGSSTMAWIKNVDDEYRITARIQESLEQLKIQIQNIDVRRIAEKLKQQIKIFDVKQVL
EKLKRSLPIKKMKEVLEQIKDFILNWMEDYEVSEKISAFRGHIHKLIVKYEIDKQVYFLM
DRMTELLNQYRIKETVQKLTVYLKKIDVKTYFDKIVAFIDDAVKKVQTFDYEMMIKEVNK
FLDMVIKKLKSFDYNQFVDKTNEKIQEVTQKINEELRNLELPQKAEAL-KQYMKDFSAVI
SKYIEQLKDTKLAAIINWLKELINSTTFANLKAKVNEHLEDLRERISDMDISKEFEWYLQ
KISQFYNSAVIYISEQWNIAFKKIVILAEEYDLKNWAENLNQFVETGFKVPEIRIVIVTI
PAFEFSLRSLQEATFRTPDFIVPLTDLHIPSYEINIKRLKDMKIPMKFTTPEFTVLNSFK
VPSYTIDLNEIKLQIVRTIDQLMSGDFQLPAIDLYFKDLKMRDMPFSDISFPELQMPQFQ
IPELLVPKLNLNELQIPDLKIPEFQLPRIPHTVTVPTFGKLSGAFRVTSPFFTLSTQAEV
HNTTT-SVNSPEFVTSLSAQTTSKLDFLVFSVIADSRLLAPEM--KQLNVKNSMKVNHRF
LKVDHTNELVFLGTSVEGEAETRANFYTTKNSIELQNKLMVKLQRKIWIQSGTAYSHRLN
IPQAPFSSQADFVNNMTTEVEAGHISFTSNGKGNWKWASPNFSDEGTHDSHATFRVEGPI
IIFFGDYRINDKYLKVSQAVRYECGFLNYATLQIQSEIESQRVGRSVLNVKGTVQLGGMK
VELTGSHNARLNGRITGTVNNEVFFLAQPFEIRVLTNNDGNVKISFPMKLTGKIDFLNNY
GLSLSSSVQQVSWQATGRFNQYRYSHNMSAGNNDDRIEAHVEMSGDANLDFLNIPLTIPQ
LN--VPYTGIQTPQ-LKDFSLWERVGLKDLLKTTRQSFDLNLNAQYEKNKDMHVIPLPLA
TVHEALNKYINFFNKYFERGRNTALDFLTKSYNEAKTKFDKYKIQTSLNKLPRTFRIPGY
TIPI---VNVEVSPFTAEMPAFGYMLPKEISTTGFTVPFIGFSVPSYTLVLP-SLELPVL
HVPQDLRTLKLPRFRINSPSNHILIPAMGNITYDFSFKSSVITLTANAGLFNQSDIAGQL
SISSSSVFDALQFKLDGSTSLTRKRGLKLATALSLSNNKFLGGGHDSTISLTRRNMEASL
TTNAQINTPVLKVNFSQELSGNTKSKPTLSSGLKVMYDFNTPKYGTSAKGGITHKFALES
L-----TSYLSVESSTKGNIDGVIYTGNSFSGTLVHEANTYLNANGARSSLKLETNSQAD
GLWNSDMKEILAVEASTRRVYAVWEHNGKNYARYTPLFTTTGSQKCKATFEMAPWSMSAD
LQIQATQPNSFLDIASINQVVLMKINTVNQKVGWKGESQIQSLSLGHDMQLLNEKSKVKF
DISGSLGGYIDFLKKMKCPIADKSLWDILKLDVTTSADRKQYLNASASLVYTKSDDGTFF
PIPVNKLTDGFTFNIPEFHLKVPSPVFSTPEFRVPFTTLQVPAYTIDLRNIKIPQTLNMM
PFDVNLPTLPRLRFPKVDVGANYITLEEYKIPYFELTVPEYQITVSQFTLPKSISLGSFH
INLDEVANKIADFDFPTITIPEQKIEIPPLKVSLPAGIYIPSFGALTGSFKAVSPLYNVT
WRTDLSNKKDSFELSVDSTCSSTLLFLEYDLNAVSNCKYEGDMFVMKTTGSLSHRDLSAN
YKQDVTLRGFGIVANTASLDIISPTFTDVHVRYQKTDS-TISSSVSSPSAGTLGYLIEVE
T-DILKKKV---YYR-TRSAPQKDIDILSSEI---SFKNPHLIQMKFNWKEDAAK-DLLL
GLKDKVPKMTNAVYRSVNWYHKEHMGLDISAATWKMKNIMQNNADKAYAFAAKQIDQID-
-AKLRTAANEASGKYQEMKVKAKQLYQKAA-DQAGQIEYQKIKAKLLDATIDIIEEYHKK
IKHLIDSVIEFLKTTKFQVPGLSEKYTGEELYLMTTEKAAKTADMCLSKLQEYFDALIAA
INELE----------VRVPASETILR-------------GRNVLDQIKEMLKHLQEKIRQ
TFATLQEADF-AGKLNHLKQIV-QQTFQKAEDIVRSLQSKNFEDIKVQTQQLYKDAMASV
YAQKLRSLAEDVKKYVSHVK----VFSQKTFQELSEKLHQLLLYIRALREEYFDPTTLGW
SLKYYEVEDKVLGWLKNLIDTLVNWQTRYVGDLADSFTRLADQVRELVEKYSQEYYDLIA
DVEGKGKQKVMELSSAAQEKIRYWSAAAKKKINEYNKQVKAKLQEIYEQLSDSQEKLIGE
AKKLIDLTIEKYSALLQYISELLRWLEQ-VTADSIKPYIAVRQGELRIDVP--FDWESIN
QMPQKSREALRKKVELTRTL---IQQGI----------------------EQGSRKWEEM
QKFIDEQLATEQLS---------------------LQQIVENIQKRMKT-----------
------------------------------------------------------------
------------------------------------------------------------
--------------------------

----------------------------------------------------------XX
XXXXXXXXXXXXXXXXXXXXXXXXAEEEVLENAT-PICSRDATR

PF01347 // ENSGT00590000083139_0_Domain_0 (105, 673)

FRHLRKYVYSYEAESS
SGVPGTADSRSVTRINCKAELEVPQPCSFILKTSQCTLKEVYGFNPEGKALLKKTKNSEE
FAAAMSRYEL-KLAIPEGKQVFLYPEKDEPTHILNIKRGIISALLVPSETEEAQQVL---
FQETVYGNCSTDFTVKTRKGNVATEISTERD----LGRCDRFKPISTGTSPLALIKGITR
PLSTLISSSQSC-QYTLDAKRKHVAEAICKEQHLFLPFSYKNKYGMMTQVTQTLKLEDMP
--KINSRFFGEG-TNKMGLAFESTKSTSPPKQ-AEAVLKTLQELKKLTVSEQNSQRANLF
NMLVTELRGLSDEAVTSLLPQLIEVSS--PITLQALVQCGRPQCYTHILQWLSRVHANPL
LIDVVTYLVALIPEPSAQQLREIFNTAREQRSRATLYALSHVVNNYHE-TNPTGTQEL-L
DVANYLMEQIQDDCTGDEDYTYLILRVIGNMGQTMEQVTPELKSSILKCVQSTKPSLMIQ
KAAIQALRKMELKNKDQEVLLQTFLDGASPGDKRLAAYLMLMRNPSQADINKIVQLLPRE
QNEQVKNFVASH

ENSGT00590000083139_0_Linker_0_3 (673, 709)

IANILKSEELYIQDLQKLVTEALKESQ-LPTVMDFR

PF09172 // ENSGT00590000083139_0_Domain_3 (709, 1017)

KFSRNYQLSKSV
SLPSLD-SASAKIEGNLIFDPNNYLPKESMLKTTLTVFGFAPADLFEIGLEGKGFEPTLE
ALFGKQGFFPDSVNKALYWVKGQVPDGVSKVLVDHFGYTKDDKREQDMVKGMMLSVEKLI
KDLKSKEVPEARAYLRILGEELGFARLHDLQLLGKLFLMGARTLQGIPQVIG-EIIREGS
KNDFFLHYIFADYAFELPTGAGLQFQMSSSGVITPGAKAGVKLEVA-NMEAELVTKPSVS
VELVTNMGIIIPDFARSGVQMHTNVFHESGLEARVALKAGQLKFIIPSPKRPVKLF

ENSGT00590000083139_0_Linker_3_5 (1017, 1044)

SGGN
TLYLVSTT----KTEVIPPLIEN

PF06448 // ENSGT00590000083139_0_Domain_5 (1044, 1156)

RQSWSTCKPFFTGLNYCTSG-AYSNASSTDSASYYPL
TGNTRLELELRPTGEIEQYSVSATYELQREDRALVDTLKFVTQAEGVEQTKATMTFKYNR
QSMTLSSEVQIPDLD

ENSGT00590000083139_0_Linker_5_6 (1156, 4658)

VDLGTIVRVHDESTKGKKSYRLTLDIQNQKITEAALMGHLSCDTK
EEGKIKGVISIPRLQAEARSEILTHWSPAKLLLQMDSS--ATAYGSTVSKRLAWHYDEEK
IEFEWNTGTNVDTKKMASNFPN-----IPDLLGSLTFIVIGLLNTRIPPTDMTLWYMGSK
LIDTTESWLQQASESLPYAQTLQDHLNGLMELNLQNMEWPDFDIPENLFLKSDGRVKYTL
NKNSLKIEIPLPFGGKSSRDLKMLETIRTPALQFKSVGFHLPSQEFQVPTFTIPELYQLQ
VPLLGILDLSTNVYSNLYNWSASYTGGNTST-D--HFSLRASYHMKADSVLDVLSYNVQG
SGETTYDHKNTLTLSCDGSLRHKF-LNSNVKFSHVEKVGNNPVSKGL---LTFDASSTWG
PQMSASVHLDSKKKQHLLVKEVKIDGQFRVSSFYAEGIYGLSCQRDPNTGQLNGESNLRF
NSTYLQGTNQITGRYEDGTLSLTSTSDLQSGIIKNTASLKYENYELTLKSDTNGKYKNFA
TSNKMDMTFSKQNALLRSEYQANYESLRFFSLLSGSLNSHGLELNADILGTDKINSGAHK
ATLRIGQDGVSTSAMTSLKYSPLVLENELNAELGLSGASMKLTTNGRFREHNAKFSLDGK
AALTELSLGSAYQAMILGVDSKNLFNFKISQEGLKLSNDMMGSYKEMKFDHTNSLNIAGL
SLDFSSKLDNIYSSDKFYKQTFNLQLQPYSLVTTINNDLKYNALDLTNNGKLRLEPLKLN
VAGNLKGAYGNNEIKHIYTIAYAALS-ASYKADT---VAKVQGVEFSHRLNTDIAGLASA
VDISTNYNSDSLHFSNVFHSVMAPFTMTIDAHTNGNGKLALWGEHTGQLYSKFLLKAEPL
AFTFSHDYKGSTSHHLMSRKSISTTLEHKASALLTPAEQMGTWKLKTQFNNNEYSQDLEA
YNTKDKIGVELSGRALADLTLLDSPIKVPFLLSEPVNVIDALEMKDAIETPQEFTIVAFV
KYDKNQDVHAISLPFSEPLQEYFERSVQTVIIILDNMQKGLKNININQFVRKYRAALGKL
PQQVDDYLNSFNWERQVSHAKEKLTALTKKYRITENDIQIALDDAKINFNEKLSQLQTYV
IQFDHYIKDNYDLHDLKIAIADIIDRIIEKLRSLDEDYHIRVNLVKTIHDLHLFIENIDF
NKIGSSTASWIQNVDTKYQIRIQIQEKLQQTKRHIQNIDMQHLAGKLKQYVEATDVRVLL
DQLGTTISFERINDILEYVKYFVINLLGDFEVAEKINAFRTKVHELIERYEIDQQIQVLM
DKSVELAHQFKLKETTQKLSNVLQQVKIKDYFEKLIGLIDDAVKQLDELSFKTFIDNVNK
FLDMLIKKLRSFDYHQFVNETNNKIHEVTQRLNGEIQALELPQKAKAL-KLFLEDTKATV
AVYLESLQDTKITLIIDWLQDALSSASFAHMRAKFRETLEDTRDRMYQMDIQQELQRYLS
LVGQVYSTLVTYISDWWTLAAKNLTDFAEQYSIQDWAKRVKALVERGFTVPEIKTILGTM
PAFEVSLQALQKATFQTPDFILPLTDLRIPSVQINFKELKDIKIPSRFSTPEFTLLNTFH
IPSFTIDFVEIKVKIIRTIDQMLNSELQWPVPELYLRDLKVEDIPLARITLPDVHLPEIT
IPEFIIPNLNLSDFQVPDLHIPEFQLPHISHTIEVPTFGKLYGILKIQSPLFTLDANADL
QNETT-SVNKAGIAASITAKGESRLEVLSFDFQAKAQLSAPKI--NPLALKESVKFSSKY
LRTEHDSEMLFFGNAIEGKSNTVASLHTEKNTLELSNGVIVKTNNQLTLDSNTKYFHNLN
IPKLDFSSQADLRSEVKTLLEAGHIAWTSSGKGSWKWACPQFLDEGTHESQISFTMEGPL
TSFELSNKINSKHLIVNQNLVYESGFLNFSKLEIQSQVESQHVGRSILTAKGTTLFGEGK
AELTGRHDAHLNGKVIGTLKNSLFFSAQPFEFTITTNNEGNLKVSFPLRATGKIDFLNNY
ALFLSPGAQQAGWQVSARFNQYKYNQNFSAENNENIMEAHVGINGEANLGFLNISLTIPE
ML--LPYTTITTTP-LKNFSLWEETGLKELLKTTKQSFDLSVKAQYKKNKHKHSITNPLA
VLYEFISQNIKSFDRHFEKARNNALDFVTKSYKEAKIKFDKYKAEKSHNELPRTFQIPGY
TVPV---VNVEVSPITTEMSAFGYVIPKAVSMPSFTISGSDIHVPSYTLTLP-SLELPVL
QVPRHL-KLSLPDFKELCTISHFFIPAMGNITYDFSFKSSVITLNTNAELFNQSDIVAHL
LSSSSSVIDALQYKLEGTTRLTRRRGLKLATALSLS-NKFVEGSHNSTVSLTKKNMEASV
VTAAKVQIPILRMNFKQELNGHTKSKPTISSFMEFKYDFNSPILYYTAKGAVDHKLSLES
H-----TSYFSIESSTKGDVKGLVLF-REYSATIASEASTYLNSKSTRSSVKLQGTSKID
DIWNLEVKENFAGEATLQRIYSLWEHSTKNRLQLEGLFFTNGEHTSKATLELSPWEMSAL
VQVHASQPSSFLDIPYLGQEVALNANTKNQKIRWKSEARVHSGSLHSRVELSNDQEEAHL
EFAGSLEGHLRFLKNIILPVYDKSLWDFLKLDVTTSLGRRQHLRVSTALVYTKNPNGYSF
SIPVKVLADEFI--IPGLKLNDLNSVLVMPAFYVPFTDLQVPSYKLDFREIKMYKKLRTS
SFALSLPTLPKVKFPEVDVLTKYSQPEDSLVPFFEITVPQSQLIVSQFTLPKSVSVGGAV
LDLNEVAKKIADFELPTIIMPEQTIEIPSVKFSVPAGIFIPSFGALTARFGVASPLYNAT
WSASLKNKTDHLETVLDSTCSSTIQFLEYDLNVVETLKIKDGRLTCKTKGTFSHRDFSAE
YEEDGKYEGLIEWEGKVHLNIKSPAFTDLNLHYQEDEK-GLSISAASPAIGTMGMDVDED
D-DFFKWNF---HYS-PQSSPDKKFTIFKTELR--YQESDEELQIKVNWEEEAAS-GLLT
SLKDSVPKATQALYNYVNKYHREHTGLTLREASSKLRRNLQNKAEWVYQGATRQIDDMD-
-MWFQKAASGTTGNYQKWIDKAQNLYQELL-TQEAQASLQEFKDKVFDSLIRVTQEFRMK
VKHLIDSLIDFLTFPRFQVPGKPGTYTRDELCTMVIREVGMVLSQVYSKVHNGSEILFSY
FQDLV----------IKLPFVLRSQK---------VIDIILICREQLK----DLSKEAQN
VFENMQSLKT-TEVLHDLQQLL-QFIFQLIEADIKKLKEIKLTELTKHIRDDINIIFNDY
IPFFFKLLKEILCLNLYTFN----EFIQNNLQEASQELQQIHQYVMALREEYFDPSVVGW
TVKYYELEEKIVSLIKNLLVALKDFHSEYTVSASDFASQLSTQVEQFLHRNIQEYLSILT
DADGKGKEKIEELSTTAQEIIKSWAIAMKAIISDYHQ

PF12491 // ENSGT00590000083139_0_Domain_6 (4658, 4716)

QFRYKLQDFSDQLSDYNEKFIAE
SKRLIDLSIQNYHTFLRYITELLKKLQS-TTV--MNPFMKLAPGELTIIL----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------

-----------------------------------------------MGASRPTLP----
------LLL----LLLLLTAAIGRAQQEVLESVS-PSCSKDATR

PF01347 // ENSGT00590000083139_0_Domain_0 (105, 674)

FKHFRKYLYNYEVESS
SGVPGTADSRSTTRINCKVELEVPHLCSFILRTSQCMLREVYAFSPEGKALLRKMKSSEE
FAAAMARHEL-RLTAAEGKRVSLYPEADEPKHILNIKRGIISALLAPLETNMDTQEL---
FQXXXXXXXXXXXXXXXXXXXXXXXXXXXXX----X-XXXXXXXXXXXXXXXXXXXXXXA
RPSTLISSSQSC-QYTLDARGKHVSEATCKEQHLFLPFSYKNKYGMMVHITQSLKLEDIP
--KINSRIFIEG-TQRVGLAFENTKATSPPKQ-AEAVLKTLQELRKLSISEQNAQRANLF
NKLVTELRGLSSEAVASLLPQLIQVSS--PITLQALVQCGQPQCYTHILQWLKSEGGNPL
LIDIATYLLALIPDPSEHRLQEIFNTTKEQQSRATFYALSRVVNSYYV--THRVTQDL-H
DIADFLVEQIGTECDRDEDHTYLILRAI-NMGKTMEPVT-TVKSAVLKCIQSTR-SLLIQ
KAAIQ-LRKMEMTDEVQGILLQTLLDDTSPTDKRLAAYLMLIRGASQSAIKQIAQLLPGE
KNEQVKNFVASHL

ENSGT00590000083139_0_Linker_0_3 (674, 709)

ANILNSEEPHIQDLKDLVKAALEGSQ-LPSVMDFR

PF09172 // ENSGT00590000083139_0_Domain_3 (709, 1025)

KFSRNYQLSKSV
SLPSLA-PVSAKIEGNLIFDSDNYIPKESMLKTTLSVFGFAPADLFEIGLEGKGFEPTLE
ALFGKQGFFPDSVNKALYWVDGRVPDFISKVLRDYFGYTKEDKREQDMVNGMMQSFHKLL
RDLNSKEVPEARAYLRILGEELGFVKFQDLQLLRNLLLNGARTLQGIPKMXX-XXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XMQAELVVKPSVS
VEFVTSMGIIIPDFARSGIQMNTNFFHESGLETRVALKSGQLKFIIPSPKGPVKLFSASN
SLHL

ENSGT00590000083139_0_Linker_3_5 (1025, 1041)

ISTT----KTEVIPPL

PF06448 // ENSGT00590000083139_0_Domain_5 (1041, 1157)

SENRQSWSTCRPFFTGLNYCIMG-AYSNASSTDSASYYPL
TGDTRFELELTPTGEVEQYSASATYELKGDDAALVDTLTFVTQAEGVKQTEAIMMFKYNR
QSRTLSSAIQIPDFNVDLGTILRLNDESEKDKKSYKLTLDIQNKKITEVTLMGHVSCDMR
GEGKIKGVISIPRLQAEARSEILTHWSLAKLLLQMDSS--ATAYGSTLSKRVAWRYDNEK
IEFEWNAGTNVDTKKLASNFPV----DLSDYPSSLHVYANSLLDYRVPQTDMTFRHVGSK
LILATNTWLQEASQSLPYAQTLQYHLSGLQELNLQKMGLPDFHIPENLFLKSDGRVKYTL
NKNVMTIDIPLPLGGKSSKDLKLLETIRTPALNFHPVGFYLPPKEFQVPTFTIPKLYQLR
VPLLGVLDLSTNIYSNVYNWSASYTGGNTSA-D--HFSLQARYRVKADSVVDLFSYSVQG
SGETTYDHRNTFTLSCDGALRHKF-LHSNFKFSHVEKVGSNPASKGF---LTFDASSAWG
PQMSASVYLDSKKKQHLYIREVKMDGQFRASSFYAKGMYGLSCRRDLTTGWLSGESNLKF
NSSYFEGTNQIIGRYEDGTLSLTSTSDLQGGIFKNSASLKYENYELTLKSDANGKYEDFA
TSNKLDLTLSKENALLRAEYQADYKSLRFFALLSGLLNSQVLELNADILGTDKINTAAHK
ATLRIGQNGISTSATTSLRYSPLMLENELNAELALSGASVKLITNGRFKEHNAKFSLDGK
AALTEVSLGSAYQAMILGADSKNVFNFKISQEGLKLSNDMMGSYAGMKFDYTNNLNIAGL
SLDLSSKSDNIYSSDKFYKQNFNFQLQPYSLVTTLNSDLKYSAFGLTSSGKLRLEPLKLN
MAGDLKGFYHNDEIKHGYIISYADLS-ASYKAET---VAKVQGVRFNHRINTDIGWLVSS
VDISTNYNSDSLHFN-IFHSVMGPFSLTIDSLTNGNG-LVLWGEHTGKLYSKFVLKAEPL
AFTFSHDYQGSLRHHLLTRGIVSTTFDHKVNALLSPTEQKGTWKLKTQINNNEYSQDFEA
YNNKDKIGVELKGGALVDLMMLDYPIEVPLLLREPINIIDALELRDAIDKPQEFTIVYFI
KYDKNQDVHTINLPFLNSLLEYFERNHA-VVTALETIQGELKRINVDQFVRSYRATLGKL
PQQANDYLNALNWEKQVLSAKEKLTAFTKNYKLTDHDLQSALDNAKINLNEKLSQLQTYV
IQFDQYIKDNYDLRDFKIAIAKIIDQIIEKLKILDEHYHLRVHLVKSIHNLYLLIENIDF
KKTESSAASWIQNVDTKYQIRIWILETLQQLKTQIQNVDIPHLAGKLKQQIEALDVTVLL
AQLRTTIPFHKISDIIEYVKYFVINLIENFEITENVKALRATVLELIKKYEVNQQIKEIV
DRLVELAHQYKLNETIQKLSNVLQGVEIQDYFEKLVGFVDDAVIQLKALTFEKLIEEVNR
FLDLLVKKLKSFDYHQFVDETNNKIREVTQKINYAIQALEIAQKAEAL-KLFVDDVKAMV
LDCLEKLKDTKVTLVTDWLQDALNSISLIHVKAKFVETLEDIRDRVYQMDIQQELMRYLS
LTGQAYSTLVTYISDWWRLAAKNLTDLAEQYSIQDWAENLKALVEQGFTVPKIQTTLGTM
PAFEISLRALQEATFHTPEFIVPFTDLRIPSVQINFKELKDIKIPSRFSTQNFTILN-FH
IPSFTIDLAEIKVKIIRTIDQMLTSELQWPIPEVYLKDLKL-DSILARITLPDFHLPEIT
VPEFTLPNLSFKDLQVPDLHIPEFKLPHFSNTIKVPTFGKLYGGLKIQSPLLTLDANADI
KNGTA-SAEKAVFTASVAAKGESRLEVLNFDFQANAQLSDSKI--NPWVLKESMKFSSKY
LRTQHESELLIFGNAIEGKSDTVASLHTARNTLELHNAVMVKMNTQLALESSTNYSHTLS
IPNLDFSSQADLQNEIKTLLEAGYMTWTSSGTGTWKWACPKFSDEGTHESQISFTMTTPI
TSFGLSNKINSKYLKVNQNVAYNSGLFNFSKFEIQSQIESQYLGHSILTAKGTALLEEGK
AEMNGNHVAHLNGKVSGTLKNSLSVLAQPFEITASMNNEGNLKVGFPLKLTGKIDFLNNY
ALLLSPRAQQASWQASARFNQYKYNHNFSAGNNENSLEAHIGINGDANLDFLNIPLTIPE
MX--XXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXX---XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXNVPSYTLTLP-SIELPVL
HIPKNLLKISFPDFEELKTINNIFIPAMGNITYDFSFKSTVITLNTNAGLYNQSDIVAHF
LSSSSSVIEALQYKLEGTSSLTRKRGLKLATALSLN-NKFLGGTHDSTISLTKKSMDVSL
ATSADVHIPTLRMNFKQELTGNTKSKPIVSSSIELKYDFNSTKLHSTVKGAVKHKLNLES
L-----TSYFSIESSTGGDIKGSFFS-REYSGTVASEANTYLNPKGTRSSVKLHGASRLD
DIWNLEVKENFAGEATFQRIYAMWEHNAKNSLQLQYFFYTHGEQMSKATLELSPWTMSAL
VQVRGNQPNHLLDIPYFGQGVGLNANFKNQQLNWS-EVQLNMGSLQHKVQLSYNT-EARL
DNAGSLXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXFFEITVPEFQVTVSQLTFPKSIPVGSTV
LNLNEVVNKIAEFELPSITGPEQTIQIPSTKLSVPAGIFIPFFGTLTTQFGLASPLYNAT
WSAGLKNKEDHVETFLDSTCSSTIQFLEYDLNVVGTHKMEDGVFICETKGTFAHRDFSAE
YKERIKYKGLWDWEGESRLDVTSPALTDFHMYYHRDDK-TLSFWEASPAVGTIGMDLESG
E-DSLKWNF---YFY-PQSSPAKKLNILKTELR--YKEVDREIQIEAHWEKEAAS-RLIG
YLQDNVPKAVMAFHDYVSKYHQEHTGLSLRDASLRLRRSLHNSAEQAYQEAMRQTDEMH-
-VRLQRAASSTTRTYQEWQDKAQTLYQELL-AQEDQMTSQRLKQKVVDSLVWVFQEYHKA
AKRVIDSFFDFLKFITFQLPGKEGMYTGDELCTMVLRKMGKVLSQLQSGIHTGLEMLLSY
TQD----------LVIRHSFDSKGYK---------LTDLILACRKLFE----YLSQEIQK
AFNKLQSATF-TEILNYVQDIL-EGGFQNIEKEIKRLKDIEFTDAIHDINV-V---VQNL
IPYG-GYLKENLYLNLDKFN----EFVQNKLKEAYQELQKFQQYIKALHEEYFDPSLAGW
TEKYYELEEKIINVIHSLVAVLKDLHSKFTVSAAGFASQLSNQVEQFMHRDIQEYLSILT
DADGKRKEKIAELSSVTQEIIKNWATVMKEIISDYHQQFRYKLQDFSDLLSNYPENFIAE
SKRLINQSIQSCHMFLSYIVELLMNLRL-AIGSEMSPHIKLAPEELTINF----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------

-----------------------------------------------MGPPQ--------
------------LWLLLLLSSGAWTQDDGSENTN-PFCSRDTTR

PF01347 // ENSGT00590000083139_0_Domain_0 (105, 673)

FKHLRKYVYNYEAETT
SGVTGTADTRSGSKITCKVELEVPQLCHFNLRTSQCSLREVAGINPEGEALLKKSKSSDD
FAMAMSKYEL-KFTIKDQNKVQLYAEDDEPMHILNIKRGIISALIVPIETESEAQTL---
TMDTVYGKCESEIKNRKNGAATAGEIEIKRD----LKSCDNFIPIRDFVSPIALIKGLNA
PLSTLISSNQHC-QYTIDPKKRHVSGVVCSEKHLFLPSSYKNQYGMMATVKQVLRIEDTP
--RINNREMEVYGLQKRQLSLEGVKTKSSK--HGDAVLKVLQELQRLSVTQQNQKRASLF
YRFVTGLRGLHNETLGPLVPKLMETSS--SITIQALSQCGTLECYGALLQILRTSNVDPL
IADAITYSLGLLSSPSTRMIQELLNMAQYQQSRATFYALSHAVNRFYN-EIGPLKKEI-N
DVANFMISLIGNECSNEDELTYLTLKAIGNMGNVLDENNANLKNSVKTCIRSNAASPEVQ
KAAIQALRKMTINDEDRGLLVKVFQEASSPVDKRLAAYLMLMRNPSTSDISKVIKTLQRD
KNEQVKSFIASH

ENSGT00590000083139_0_Linker_0_3 (673, 728)

IANILDSENPYIELIRNKVQEAINRDQ-LPTARHFQKFSRNYQIFKSL
SIPWEN-

PF09172 // ENSGT00590000083139_0_Domain_3 (728, 1025)

PVMGQLEGNLIFEPESYVPRESMLKTTLEVVGMRAMDLFEIGLDGKNFEPTLD
AMFGPKGFFPDSATKALYWIDGKVPDQVSQVLFDYFGYTKDGKQDQDVMKGVMLNFEKLI
KEIVNKDSPEAKAYLRILGEELGYLKLSDIKLVGNLIMRSLRTLETGLEKIT-QAVSKGT
ENDLFAHYIFMDNEFELLTGAGLQLQFALSGVATPGMKAGVKISQR-NMKAELIAKPSMA
VEFVTHLGVNIPEFARSGVQMNTNMYHESGIEAHVGVRAGQLKLTIPAPKSPTKLFSLSN
VLHL

ENSGT00590000083139_0_Linker_3_5 (1025, 1042)

VTPT----RIEVIPPLI

PF06448 // ENSGT00590000083139_0_Domain_5 (1042, 1156)

ENRESQTSCTRFFAGLNMCVRV-EYSNASSTEAAPYYPL
TGETRYEVEIQPTGEVKEYTASANYELKREEEDLVDTMKFIAQAEGIKKSEATLTLRYNR
GKHIFTSDLQIPSFD

ENSGT00590000083139_0_Linker_5_6 (1156, 4658)

IDFGTNLRITDSSSEQRKAYAFILDINNKKIPEVTLTGRIGYQAG
RESSIEASISIPRLQTQAKTDVSLLRQSTGIIFQTDSS--ATAHGSSISERIVLRYDNEK
IEVQWNSGTSAALKKMSGKLPI----DLDEYSKALQRQTSELLDHKVANTDMTFRHIISH
FITATNTWLHQASSDVPYAQQLKDKLSGLQDLNFQIMNLIT--IPEELFLRSDGQIKYIW
NKEKTVFTIPVPFGGRSSYDMRVPKTVRTPPLVLESLGVSMPSQEYRIPPFTIPESYTLQ
VPLLGTFEISSNIYSNYYNWSGSYSLANTTSD---AYSLKTSYFMKADSVLDLLSYSTQG
QGEAKYD-KNVFTIDYENLLQHSL-LNSNFKISKLDIIEPSRISRYR---ITAGASSPLG
AKFSLSYGGDAKFSNMLLTANENLESQLDVASAFAKVTYTDTGTYDLNNNAIAGESNLKF
DSSFLQATNQLTKRFTNEVWAVTSISNVQNGFLTNTASLKYQDSRLMLSSETAGKHRDYT
AFNKFDLTLQRQGASLSSEYRASCTQGQGYALISGSVNNRGAELISHMLARGERNKAEHK
STLSINQDGLASSATTTLQFNPLTLENEMNARIAISGASMKINTNGRFGKHHAKFDWDGK
ASLKEIGIASVYQGSISDVDSKNTLNFRVNKGGLKLSNSLIGSYKEMKLEHTHDLNMVGL
TLTYTSTLDHTISLDKSHKHRLEMQLKPYSLTANVNSDLKYASANANNKAQLQLELLKVN
LDGNVKAAYGGDEVKHSYTFTYADLA-AHLKTDT---VASIQGAALMHRVNVDVAGLSSS
VAINSNCNSKFLTFSNEMRSVVAPFTITVDMHTNGDGRLMVFGEQSGRLYSKFLLKAEPL
AFTFSHFYKGSTDHNLNSGKRYNTLLDNKVVVIFTPSEQSSTWTMKSQLNNHAYTQDLNI
FNNAEKIGMELSGQTLADLSVLDFPINIPFTTTRRINLIDTFDLRENLAHPQEFGLSLSV
KYDKNEDVHIINLPFLETLPVHYERYRQSILTALKSIQKNLRSINMDQFMRKYKATLDKL
PQQINSYINSIDFENRMTILKDKWETFLKDYSITVDDLKHALDSASSSLGEALFQLETFL
TNADNYIRENYDLK---ATIVQLIEQIIEKLKVIDQQFKISTQIIDTIQQLQSAISQYDP
SQIGSSAAAWVQNIDTEYKIKAQLQEKLDQLKRQIQSIDAQHIAESLKQQVEAIDIKILL
EKLKMSLPLQKMKDYIEQIQTLILNFLEDYEVFEKILVFQTKLHELLVNYKVDQQVNVLI
EKFIEFSNQQRIKETIQKITLSLRKIDVKSFFNQVLKFIDDAVQQLQTVDYKNLVDKVND
FLDDLIKKLRSFDYNKFVDETNIKIQEARQKINDEIRALELPQKVEAA-KRYVRDVSHVV
SQYIEELKDSRFAVIVNWFN-LLSSTITDELKVKVCDYLKDARDRIYQMDIAMECQRYLE
RASQLYNTIITYLADQWYIASKKITDLAEKYNVKNMADSLNQFVETGFKVPEISTGVINI
PSFEISLRALREATFQTPDFIIPLTDLRVPSYQVNFKKLKEITIPTRFETPEFTILNTYK
IPSYIIDLNEIKLQIVKTIDQILTSDFRLPPADAYFQDLRMQDMSFSDFSFPEMDLPDLQ
IPEFIIPKLNLNDFQFPDVQIPEFKLPRIPHSVTAPTFGKLSGAFRVASPFFTLTTNAGL
QNVTA-FDHSPEFMASISAISTSKINFLAFTITADTHLLAPEM--QRLILRDNFKFSHVY
LKADHAGEIIFSRTSIDGNAETTANLRTTRNALDLHNKLTLNLQKKISMESKTTYTHKLN
IPVALFTSQAELSNEIKTVLEAGRISLTSIGKGDWKWATYDYSDEGTHESSVSFTVGGSV
AALVAENKITDKYLKVNQRLAYEYNLPSFAKLQIESTVESPQLGHSTINIQGTGNLAEMK
MKVTGTQNAKMNGRISGTLNNDVAFLVQPFEVSASTNNDANIKISFLPKMTGKIEFLNNY
GLMLSPSTQQISWVAEGRFNQYRYAHNMSASNNEDSIGAFLSMNGDANLDFLTKPISLPE
LA--VPYVGIQTPT-VQEYCLWEETGLKNLLKTPKQSFDLNLKAQYKKNKYMHSFQIPLD
GVHRAINDYIVFFNKHFEKGRDNALAFLTESYNQAKTNFDIYKVDTSASQIPQIFRIPGY
TIPV---VNIEVSPFTAELPAFGYIIPKEMSTPSFTVPLVGFSVPSYTLVLP-SLELPVL
HVPQGLQTLKLPSYRTYAPSNRIYIPALGNITYEFSFKSSVITLNTNAGFFNQSDIVAHL
SSSSTSVIDALQYKLDGTTSLTRKRSLKLATALSL-NHKFIEGNHDSTISLTKRNIEASV
ITTAKINMPGLKVNFGQELKGNTKSKPIITSAINLNYDLDTGVA--NAKGEVAHKVTVES
I-----ISYISVDTSTNGFINGNIYKEIPFSGKLVHEANAYLNAKGGRASFQLETNSNVD
EMWNFGMKENVAFEASSQRLYALWDHNAENKLFPHLIVSTKGNQNCKVTLELGSTGMSVI
GQIQAIQYNNIIGEASANQAFLMTISNENQKMSWTSENQIYSLFLGHDLLLTNNNTVAQF
TMSGSLGGHMDFLRH-RLPIYDRSLWDILKLDLTTSG-GRQYLNVATGIVYTKNEDGYFI
PINVNRLT-----------------------------NLQIPSYTIDLRQITVPETLATM
PFDISLPSMPKIQFPQLAILTSYVDSEDYKIPSFELTVPEYLLRVSEFTLPKTLSFGDMT
VDFNAIANKIADFDLPTITIPEQQIEIPAFKVFLPAGIYIPKFGALAGSLAIASPIYSTT
WKMDFKNKKNSFEHSIDFTAISPLQFLEYDLDAVTTCLYQDNFLKASVQSTFAHRDLSAE
YKEILIAQGRRILEHKASLDITSPTFTDVQVRYQGSDS-KVAASVSSSSAGTLGLLIDLD
S-DVFRSKI---FYR-SQSNPENDVDVLKSEI---SFKNPELIQLKANWETDGAM-DLLK
GFKERVPKMTSTLYNAVDKYHKEHTGMEMHAVALKLNDNLKRSIDSAYENTLNDISELQ-
-QQLHVVTDQATGKYETMRKKAKKLYYDAA-DQANQIDYEQIRAKFFDAAMQTIKEYNKR
IKHLIDSTIEFLKVSRFQVPGVDGKHTGEELFVMATEKLRRAVDVGITKVQEYFEAFIAF
INELE----------VKIPASRQIIK-------------GSAILDEIKGFLNHVRNKVGG
FFVGLLEIDF-AQHLRDLKEVI-QQVFQKVEELVRNLQAQNYEYISLQAKQLFTEALQGV
-----KSLAEDRKYLNPRIE----NFIQNIVETCYNKGEELLQSMKDLREEYFDPSIVGW
SVKYYEVEEKVLAWLKSLINALREWHKKYVSDSADLIVRLADQAQEFVD-----------
-----NHEKITEFSRSAHDKILYWSQTAKKSAAEQNI

PF12491 // ENSGT00590000083139_0_Domain_6 (4658, 4714)

QVKEKLQEAYEHL--SYERFITN
TKKLIDLVIENYAAFFQDLQQLLHQFEE-AAADTLRPYIMVRQGELRIDIPKPFDMSSVN
SFYQ--------PPQLRNEL---FQHSI----------------------DQNSKKGEEL
RSFTELQIYARQLT---------------------VQQIIQEVHKLVQS-----------
------------------------------------------------------------
------------------------------------------------------------
--------------------------

-----------------------------------------------MGPPRP-------
------ELLLPLLLLLLLP-NSHSSY----VADL-LLVVEEATR

PF01347 // ENSGT00590000083139_0_Domain_0 (105, 673)

FKHLRKYVYSYEAESS
SGIPGKADSRSITKINCKVELEVPQLCSFVLKTSQCTLKELHGLNLEGKALLKKTKNSED
FAAAMSRHEL-RLAFPEGKRVFLYPEEEEPKHILNIKRGIVSALLAPPETEEDTQEL---
FLDTVYGNCSTHVVVKTRKGNVATEMSTDRN----LQECTGFQPSSTGASPLALIRGLAR
PLSTLVSSSQSC-QYTLDPKRKHVSEAVCREQHLFLPFSYKNKYGMMTQVTQTLKLEDTP
--KINSRFFGEG-ALKVGLAFENTKSTFLPKQ-AEAVLKTLQELKKLTGFEPQVQRANLF
SKLVTNLRGLSSEDITSLLPRLIEVSS--PITLQALIQCGQPQCYTHVLQWLRSEKAHPL
LIDVVTYLVALIPDPSAQMLCETFNIAKEQLSRATLYALSHMVNNYFE-TTRTPNQDL-R
DIANYLQEQIQDECAGDEEHTYLILRVIGNMGRTLDNITPTIKSSILRCIGSSKPSMLIQ
KAAIQALRKMQLGDEAQQLLLQTFVDSASPGDKRLAAYLTLMKKPSQSDIGRVIQLLPRE
ENEQVKNFVVSH

ENSGT00590000083139_0_Linker_0_3 (673, 709)

IANILSSEELYIGGLKALVKEALKDSQ-LPTIMDFS

PF09172 // ENSGT00590000083139_0_Domain_3 (709, 1018)

KFSRNYQFSKSV
SLPSLD-PVSAKIEGNLIFDPNNYLPKESMLKTTLTAFGFASADLFEIGLEGKGFEPTLE
ALFGKQGFFPDSVSKALYWVNGQVPDGVSKVLVDHFGYTKDDKHEQDMINGIIPIVDKLI
KDLKSRDLPEARAYLRILGKELSFFKLQDLRLLGRLLLSGAHALRGIPQMV--KALREGW
RNDLFLYYIFMDNTFELPTGMGLQLQVSSSGVTTLGTKAGVKLEMA-KMQTDLMMRPSVS
VEFVTSIGIIMPDFARSGVRMNTNVFCGSSLEAHVALKAGELRFIVVSPKRPIKLFS

ENSGT00590000083139_0_Linker_3_5 (1018, 1044)

ISN
TLHLVSTT----KTEVLPPLIDG

PF06448 // ENSGT00590000083139_0_Domain_5 (1044, 1156)

KQSWVNCRPLIPGLNFCSTG-APSNASATESASYYPL
TGNIRYGLELRPTGDVEQYSVGATYELQREENALVDRLKFAIQAEGKKTTEATLVFKYNR
RSKTLSSEMQIPDLD

ENSGT00590000083139_0_Linker_5_6 (1156, 4658)

IDLGTILRVTDESSNDEKSYKLNLDFQNKKITEVAFTGHVSHDTN
GEGKVKGVISIPRLQAEARSEISTHWSPTKLLLHMDSS--ATAYGSAISKRVVWRYDDEK
IEFQWNTGTNVDTKKAAASFPV----DPSDYLRSLHMHANKLLDHRIPQTGMTFSEMGSK
LIVVSMNHICNALITLCHKNKK--SEHELKKLVLSKC----IENMVFVVLFSDGRIKYIL
NKNSIKVEIPLPFGGKSSRDLKMLETIRTPALSFKSLGFQLPSQEFQVPSFTIPEVYQLR
VPLLGVLDLSTNVHSNLYNLSASYTGGNTSR-D--HFRLQARYHIKADSVVNLLSYSLQG
SGETTYDHRNTFTLSCDGSLRHQL-LDSNVKLSHVEKIGNNPASKGV---LTFDISSTWG
PQMSASVHLDSKMKQQLFVKDVKIDGQLRASSFYAEGTYGLTCQRNPTTGQLRGESNLRF
NSSYLQGTNQMTGVYEDGALSLTSTSNLQGGTLKNTASLKYENYELTLKSDTSGNYENLA
TSNKVDLTFSKQNALLRSEYQADYKSLKFFSLLAGSLNSQGVELNADILGTDKINAGAHK
ATLRITRDGISTSATTNLKYSPLFLENELNAALGLSGASMKLAANGRFREHSAKFSVDGK
AALTEVSLASAYQAMLMGVDSKNVFSFRLSGEGLKVSNDLMGSYGEMTLDHANSLSIAGL
SLEFSSKLDNIYSADKFYKQNFNFQLQPFSLVTTLNNDLKYSALDLTSSGKLRLEPLKLN
VGGNLKAAYQNNEIKHIYTISYADLS-ASYKADT---LARIQGAEFSHRLSTGIAGLAAS
VDISTNYHSDSLRFNSAVHSALAPFTVAIDAHVNGNGKLALWGEHTGQLYSKFLLKAEPL
ALTFSHDYKGSTSHNLSSGKSISAALDHRLSALLTPTEQTSTWKLKTQLNNHEYSQDFDA
YNTKDKIGVELSGRGLADLTVLDFPIKVPLLLSEPINVIDALQMKDAIEQPQEFTVVAFV
KYDKNQDVHTISLPFLKTLPEYLERNRIIIITTLEIIQRELKRIDIDQFVKKYGAGLSKL
PQQVSEHLNALDWERQIAGAKEKLTAFAENYRITENDLQTALNTVKINLNEKLSQFQTYV
MQFDHYIINNYDLRDVKRAIAKIIDQITKRLKSLDERYQIRVTLVRTIHSLYLFVENVDF
NKMASSTASWIQNVDTQYQIRVQIQEKLEQIRTQIQNLDIQELAAKLKQQVEAIDIRKLL
NQLRATIPVQKINTIIEHVKYFVINLINDFEVVEKINAFRAVAHELIKKYDIDRQIXVLI
DKSVQLAHQYKLKDMVQKLSNALQQVDIKDCYEKLLVFIDDIIRELKEFSFKTIIEDVNH
LLDILVKELRSFDYHQFVNETNDTIREVIQLAN-SY--LDLPQKAEAL-KLFIEDVKVML
SAFLEKLKDTKITLFVDWLQNALNS------------TLEDVRDRIYQMDIQHELERYLS
LVGQVYNTLVTYISDWWGLTAKNLADLAEQYSIQAWAANVTALVEQGFTVPKIQTFLGTM
PAFEVSLRALQQATFQTPDFVVPLTDLKIPSVRINFKELKDIKIPSRFSTPQFTILNTFH
IPSFTIDLKDIKVRIIRTIDQMLSSELRWPVPEVYLRDLKVENILPARLMLPDFSLPEIT
IPEFAIPNLNLSEFRVPDLHIPEFQLPPISHTAKIPAFGKLNSILKIQFPLFTIDAQANV
HNVTI-SEHQAGIEAFIGAKGESKFEIFNFDFQANAQLLEPMT--DPLLLKESMNFSSKY
LRMGHGSEIVFSTNAIEGKSGTEASFHTEKNTLELKNGMIVKIKDQLTLDSLTKYSHKLN
IPKLDFSSKAELINDVNTRLEAGHVTLTSSGAGSWKWACPNFSDEGTHESQISFTMKGPL
ASLELANKINSKHVRVTQNLAYESGFLNFSKFDITSDVESQHVGHSVLNAKGIALLDKGK
VEITGDHNAHLNGKVIGTLKNSLFVSAQPFEMTASANNEGNLKVSFPLKLTGKIDFLNNY
ALLVSPAAQQANWQASARFNQYKYNQNFSALNNENSIEAHVSINGDANLEFLNVPLTIPE
MN--VSYIALTTPS-LKDFNIWEATGLKEFLKTTKQSVDLNVKIQYKKNKDKHSIAIPXX
XXXXXXXXXXXSLDSYVANVRDNSLDFLTTAYKAVKFKWDEVRAEKSRNAPPRTFQYLGY
TIPV---ISIEVSPFSAEIWPFSHVIPKAINTSSSTVPSSDFSVPSYTLVLP-SIELPEL
YIPRNLFKLSLPDLKELSDVSSLFIPAMGNMTYDFSFKSSVITLNTNAGLYNQSDIVAHF
LSSSSFVIDALQYKLEGTLRLTRKRGLKLATALSLS-NKFVEGSHDSTISFTKKNMEASL
TTSAKVHVPVLRMNFKHELNGNTKSKPAASSSIELKYDFNAPEMFPTAKGAIDHKLSLES
L-----TSYFSIESSTKADIKGLVLS-REYSGALASEASTYLNSKATRSSVKLQGSSKVD
GIWNVEVKENFAGEATPLRIYTMWEHSMKDRLRPL--LSTHGEHTSKATLELFPGAVSAL
IQVRARQLSSLFDIPHVGQEVVLNANTENQKFGWKSEVQIHSGTLKNSLQLSNDQKEARF
DIAGTLEGHLHFLKFINLPVYDKSLWDLLKLD-------RQHLHAATALVYTKNPKGFPL
SAPVQELTDKFV--IPGLKLNDPE--------------------------IKIYKKLSSS
PFAVSLPKLPKVKVPQVNVFTKYSEPGNSSVPYFEITVPEVQLTVSQFTLPKSLRIAGAV
LDLNKVASTIGDFELPTITVPEQTIEIPSIKFSVPAGVFLPLFGALTARFGVASPLYNAT
WNVGLKNNADHVETFLDSTCSSTLQFLEYDLNVVGTYKIDDAMLSYKIKGTLDHSDLSAE
YEEDGKYKGLEDWEGEASLDFRSPAFTELHLRYREDRN-SMSSSAASPAIGTVGLDLETE
GDRSFKCNL---YFQ-PQSSSDKKLTILKMDWR--YQESDDKTQMRFNWEEEAAS-RLLS
SLKDNVPKATGALYDYADKYHQEYTGLNLKD------RSVRESAEGAFRTLEELEAEVQ-
-TA--------------ASSTTGDLYQDLL-AEEGQNNSQRLKDEVFDSLIQVTHKYHKA
AKHLIHSFIDFLKLTRIQLPGMNGTYTRDELCTIVMREIGKVLSQVYSNLQNGLEKVLSY
AQDLVEKSEVIRDLQIELPYDAGCYK---------LTEVILNCRKLLE----YLSQE---
------SIKF-SEKLSDLQSFL-QIVFQEIEAEIKSLKETRLSHLTNT----VSEVVNTY
IPFTYSVLKEGLSLHLNEL-------VEFYLQTTSQGLLQIHHYVKALREEYFDPSVIGW
TVKYYELEEKIVDLIKHLAAALKDLHSMYTAHATKFASQLSTQVERFV----QEYLSILV
NADGKGRVKIAELSNTTQEGIQTLTTAMKEIVSDYQE

PF12491 // ENSGT00590000083139_0_Domain_6 (4658, 4713)

QFTSKLQELSDRFSDYHEKVIAL
FQGLIDLSIENYHMLLRYITEVLAKLQA-ATAKGGSPSIQLTSGELIITI----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------

-----------------------------------------------MGPPRP-------
------ALQAPLALGLLL-LLWGGRR-------A-RECAGDATR

PF01347 // ENSGT00590000083139_0_Domain_0 (105, 673)

FKHLRKYVYNYEAESS
SGVPGTADSRSATKINCKVELEVPQFCSFILKTSQCTLKEVYGFNPEGKALLKKTKNSEE
FAAAMSKYEL-RLTVPEGKQVFLYPEQGEPKHILNIKRGIISALLVPPETEEANQVM---
FLDTVYGNCSTQFTVKTRKGTVATEISTERN----LQQCDHFKPISTGVSPLALIRGMSR
PLSTLISSSQSC-QYTLDPKRKHVSEAICKEQHLFLPFSYKNKYGMMAHVTQTLKLEDTP
--KINSRFFGEG-AKKVGLAFESTKSASLPKQ-ADAVLKTLQELKKLSDSEQSAQRANLF
NKLVTELRGLNNEAVTSLLPRLIEVSS--PITLQALVQCGQPQCYTHILQWLKQMHAKPL
LVDIVTYLVALVPEPSAQRLQEIFNMAREQRSRATLYALSHVVNSYHK-THPTETQDL-L
DIAGYLEEQIRDDCTGEEDYTELILRVIGNMGQTMEQLAPTLKSSVLKCIKSTKPSLLIQ
KAAIQALRKMELKDEEQGVLLQTFLDGASPGDKRLAAYLMLMRAPSQSDVNEIIQLLPRE
QNEQVKNFVASH

ENSGT00590000083139_0_Linker_0_3 (673, 709)

IANILNSEELYVQDLKTLVKEALKESQ-LPTLMDFR

PF09172 // ENSGT00590000083139_0_Domain_3 (709, 1017)

KFSRNYQISKSV
SLPSLD-SASAKIEGNLIFDPNNYLPKESMLKTTLTVFGFAAADLFEIGLEGKSFEPTLE
ALFGKQGFFPDSVNKALYWVNGQVPDHVSKVLEDHFGYTKEDKREQDMVNGIMLSVEKLI
KDLKSKDVPEARAYLRILGEELGFARLRDLKFLGELLLTSARTLQGIPQMIG-EAIRQGS
KNDIFLHYIFMDNAFELPTGAGLQLQMSSSGVITPGTKAGVKLEVA-NMQAELVTKPSVS
VEFVTNMGMIIPDFARSGVQMNTNFFHESGLEARVSLRAGQLKFIIPSPKRPVKLF

ENSGT00590000083139_0_Linker_3_5 (1017, 1044)

SGSN
TLHLVSTT----KTEAIPPLIEN

PF06448 // ENSGT00590000083139_0_Domain_5 (1044, 1156)

RQSWSVCKPLFTGLNYCTSG-AYSNASSTDSASYYPL
TGDTRFELELKPTGEVEQYSVGATYELQREDSALVDTLKFVAQTEGVKHTEATMTFRYNR
QTVTLSSEVQIPDFE

ENSGT00590000083139_0_Linker_5_6 (1156, 4658)

VDFGTILRVINESVKDKVSYKLTLDIQNKKITEIAVTGHLSCDRK
EEGKIKGIISIPRLQAEARSEILTHWSSTKLLLQMDSS--ATAYGSTISKRVAWRYDEEK
IEFEWNTGSNVDTKKVASNFPV----DLSDYPRSLHMYANSLLDHRVPQTDMTFRHMGSK
LIVATNAWLQKASGSLPYAQTLQDHLDSLKEWNLQQMGLPDFHIPENLFLKSDGRVKYTF
NKNSMKMDIPLPFGGKSSKDLKMLETIRTPALHFKPMEFHLPAQEFQVPAFTIPKSYQLQ
VPLLGVLDLSTNVYSNLYNWSASYTGGNTST-D--HFSLRAQYHVKADSVVDLLSYSVQG
SGETTYDHRNTYTLSCDGSLHHKF-LDSNIKFSHVEKVGNSPVSKGL---LTFDASSAWG
PQMSASVRLGSKKKQHLYVKEVQIDGQFKVSSFYTKGTYSLSCQRDPATGQLNGESNLSF
NSSYLQGTNQITGRYEDGTFSLSSTSDLQGGLIKNIASLKYENYELTLKSDTNGKYNNFA
TSNKVDLTFSKQNALLRSEYQADYESLRFFTVLSGSLNSHGLELNADVLGTDKINSGAHK
ATLRIAQGAISTSATTNLKYSPLVLENELNAELGLSGTSMKLTTSGRYREHSAKFSLDGK
AALTEVSLGSAYQAMILGVDSKNVFNFKLSREGLKLSNDMMGSYAEMKLDHTNSLNIAGL
SLDFSSKLDNIYSSDKFYKQNFNLQLQPYSLVTTLNNDLKYNALDLTNTGKLRLEPLKLT
VGGNLKGAYQNNEIKHIYTISYAALS-ASYKADT---IAKIQGAEFSHRLSTDIAGLASA
LDISTNYNSDSLHFSNVFHSAMAPFTMAIDAHTNCNGKLALWGEHTGQLYSQFLLKAEPL
ALTFSHDYKGSTSHHLMSRKSITTALDHKVSALLTPAEQTGTWKLKTQFNNNEYSQDLDA
YNTKDKIGVELSGQALADLTLLDYPINVPFVFSE-YNVIDALEMRDAVDKPQEFTIVAFV
KYDKNQDVHTISLPFFKTLPEYFERNRRIIITVLEVIQKELKRVDIDQFVRKYRASLSKL
PQQVNDSLKSFNWERQVSSAKEKLTAFTKKYGITENDLQIALDNAKINFNEKLSQMQTYV
IQFDQYIKNNYDLHDFKTAVAKIIDLIIEKLKILDEHYHICVNLEKTIHDLYVFIENIDF
NTTGSSTASWIQNVYTEYQIRMHIQEKLQQLKAHIQNIDLQQLAGKLKQQVATIDVRVLL
DQLRTTIPFGIIHDVLESVKYI-VDLTGDFKVSEKIDAFRTAVCNLIKAYEVDQQIQALM
DKSVQLAHQYKLKETVQKLSNVLQQIEIKDYFEKLVGFIDDAVKQLDALSLKKFIEEINK
FLDMLVKKLKSFDYRQFVDETNNKISEVTRRINSKIQDLELPQKAETL-KLFLEDTKTMA
SEYLESLKDTKITLIIDWLQDALDSTSLTHMKAKFQETLEDIRDRMYQMDIQQELEQFLS
LVGQVYSTLVTYISDWWSLAAKNLTDFAEQYSIPGLAESVKVLVEKGFTVPEIRTVFGTM
PAFEVSLRALQEATFQTPDFIVPLTDLRIPSVQINFKELKDKKIPSRFSTPEFTILNILH
IPSFTIDFVEIKAKIIRTIDQMLNSELQWPVPEVYLRDLKVENIPFGRITLPDFYLSEVT
IPEFVIPNLNRNDFQFPNIHIPEFQLPHLPHSIEVPAFGKLYSILKIQSPIFTLDANADI
QNVTT-LANKADIAASIAAKGESKLEVLNFDFQANAQLSSPKI--DPLVLKESVTFSSKY
LRTKHVGEMLFSGDAMEGKSDTVASLHTEKNTLEVSNGVLVKINNQLTLDSNTKYFHKLN
IPKLDFSSQADLRNEIKTLLKAGHMAWTSSGLGSWKWACPNFSDEGIHESQINFTVKEPM
TYFGLSNRINSKHLRVNQNFVYESGFPHFSKFEIQSQVESQHVGRSILTAKGTALFREGK
AEITGNHDAHLNGKVIGTLKNSLSVSAHSFEITASTNNEGNLKVSFPLKLTGKIDFLNNY
ALFLSPTTQQTSWQASARFNQYKYNHIFSAGNNKDTIEAHVGINGEANLDFLNIPLTIPE
MT--LPYTIITTPP-LKDFSLWEKTGLKEFLKTTKQSFDLSAKAQYKKNKDQLPIPNPFR
VFYEFISQNINSFDSHFEKAQDDTLDFLTKSYNEAKIKFDKYKVEESHNNLPRTFQIPGY
TIPV---INIEVSPFTVEMLEFGYVIPKAINTPNFTLPGSDYYVPSYTLVLP-SLELPVL
HVPRNLLKLSLPDFKELGTANNIFIPAMGNITYDFSFKSSVITLNTNAGLYNQSDIVAHL
LASSSSVIDALQYKLEGTSRLTRKRGLKLATGLSLS-NKFVEGSHNSTVSLTKKNLEASV
TTTAKVQIPILRMNLKQELNGNTKSKPTVSSSIELKYDFNSPQLFSTAQGAVDHKLILES
L-----TSYFSMESSTKGDVKGSVFS-REYSGTIASEASTYLNSKGTRSSVKLQGASKVD
DIWNFEVKENFAGEATLQRIYAVWERNMKNRLQLEGLFSSHGVHTSKATLELSPWKISAL
VQVRTSQPNSLLNIPSLSQEVALNANTKNQKVSWKSEVQVHSGSVQNHIELSNDPKEAHL
DIAGALEGHLSFLKYITLPVYEKSLWDLLKLDVTTSIDRRQYLHASTSLVYTKNPNGYPF
SVPVKVLDNEFI--IPGLKLNDLSSALVTPAFQVPFTDLQVPSYKLDLSEIKIYKQLKTS
PFALNLPTLPKVEFPEVAVLTRYSQPEDSSVPFFEISVPKSQLTVSQFTLPISISVGNAV
WDLNEMASKIADFKLPTIIMPEQTVEIPAIEFSIPAGIFIPSFGALTARLGVASPLYNAT
WSAGLKNKADHVETFLDSTCSSTIQFLEYDLNVVGTHKIENGTLVCKTKGAFAHRDFSAE
YEENSKYKGLQEWKREVHLDITGAAFTDLHLHE---------KA-TSPAIGTVGIDLEKD
A-EIFKWNL---YYRSPQSSPDKKFTIFKTELR--YRESDEEIQIKVNWEDRAAS-RLLT
SLKDKVPKATGALYNYVNKYHQEHTGLTLQDASSKARRSLQNKAEWAYQGAMRQIDKMD-
-TQLWRVANDATETYQEWKDKVQTLY---------------LKDNVFDSLLRIAQEYHMT
VQSLIDSFITFMNSTRFQLPGKARMYTRDELGTMAMREVVEVLSRVHSNVQNGLEILLSY
FQDL-----------IKFHFVSGRYE---------LIDIILGCRKLLE----SLSQEIQK
ALNDLQSVKI-TKMLSDLQDIL-QRVFQEIEGEIKRLKKKKFTYLTKDIQDEIDTIFNKH
IPYVFGSLKETIYLNLGEFH----ELVQNKLEEISQELQPIQQYIKALREEYFDPSVVGW
TVKYYELEEKIFNLIKNLVLALKDFYSKYTVSAAGFVSQLSGQVKQSMHRAIQEYLSILT
DADGKGKEKIAELSATAQEIIKSLTVAMKEIISDYHQ

PF12491 // ENSGT00590000083139_0_Domain_6 (4658, 4716)

QLRYKLQDFSDQLSDYYEKFIAE
SERLIDLSIQNYHMFLRYIIELLKKLQS-TTA--MSPYIKLAPGELTVTL----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------

-----------------------------------------------MGPPRPALL----
AL---PALL-LLLAGARAEKE----M---LENVS-PVCPRDTTR

PF01347 // ENSGT00590000083139_0_Domain_0 (105, 673)

FKHLRKYTYNYEAESS
SGVPGTADSRSATRINCKVELEVPQLCSFILKTSQCTLKEVYGFNPEGRALLKKTKNSEE
FAAAMSRYEL-KLVIPEGKQVFLYPEKDEPTHILNIKRGIISALLVPPETEETKQVL---
FLDTVYGNCSTHFTVKTRKGNVATEISTERD----LGQCDRFKPIRTGVSPLALIKGMTH
PLSTLISSSQSC-QYTLDAKRKHVAEAICKEQHLFLPFSYKNMYGMGVQVTQTLKLEDTP
--KINSRFFGEG-TKKVGLAFESTKSTSPPKQ-AEAVLKTLQELKKLTISEQNIQRANLF
HKLVTELRGLSEEAVTSLLPQLIEVSS--PITLQALVQCGQPQCSTHILQWLKRVHANPL
LIDVVTYLVALIPEPSAQQLREIFNMAREQRSRATLYALSHAVNNYHK-TNPTGTQEL-L
DIANYLMEQIQDDCTGDEDYTYLILRVIGNMGQTMEQVTPELKSSILKCVQSTKPSLMIQ
KAAIQALRKMEPKDEDQEVLLQTFLDDASPGDKRLAAYLMLMRSPSQADINKIVQLLPRE
QNEQVKNFVASH

ENSGT00590000083139_0_Linker_0_3 (673, 709)

IANILNSEELDIQDLKKLVKEALKESQ-LPTVMDFR

PF09172 // ENSGT00590000083139_0_Domain_3 (709, 1017)

KFSRNYRLYKSV
SLPSLD-PASAKIEGNLIFDPNNYLPKETMLKTTLTAFGFASADLFEIGLEGKGFEPTLE
ALFGKQGFFPDSVNKALYWVNGQVPDGVSKVLVDHFGYTKEDKREQDMVNGMMFTVQKLI
EDLKSKEVPEARAYLRILGEELGFARLHDLQLLGKLLLTGARTLQGIPQMIG-EVIRKGS
KNDFFLHYIFIENAFELPTGAGLQLQISSSGVTAPGIKAGVKLEVA-NMQAELVAKPSVS
VEFVTNMGIIIPDFARSGVQMNTNFFHESGLEARVALKAGQLKFIIPSPKKPVKLL

ENSGT00590000083139_0_Linker_3_5 (1017, 1044)

SGSN
TLHLVSTT----KTEVIPPLIEN

PF06448 // ENSGT00590000083139_0_Domain_5 (1044, 1156)

RQSLSVCKQLFTGLNYCTSS-AYSNASSTDSAPYYPL
TGDTRLELELRPTGEVEQYSVSATYELQREDRALVDTLKFVTQAEGVKQTEATMTFKYNR
QSMTLSSEVQIPDFD

ENSGT00590000083139_0_Linker_5_6 (1156, 4658)

VDLGTILRVNDESTEGRKSYRLTLDIQNKKITEVTLMGHLSCDTK
EEGKIKGVISVPRLQAEARSEIIAHWSPAKLLLQMDSS--ATAYGSTVSKRVAWHYDEEK
IEFEWNTGTNVDTKKMTSNFPV----DLSEYPRSLHMYADRLLDHRVPQTDMTFRHVGSK
LIVAMNSWLQKASGSLPYTQTLQDHLNSLKELNLQNMGLPDFHIPENLFLKSDGRVKYTL
NKNSLKVEIPLPFGGKSSRDLKMLETVRTPALHFTSVDFHLPSREFQVPTFTIPKLYQLQ
VPLLGVLDLSANVYSNLYNWSASYTGGNTST-D--HFSLQARYHMKADSVVDLLSYNVQG
SGEATYDHKNTLTLSCGGSLRHKF-LDSNIKFSHVEKLGNNPVSKGL---LIFDASSSWG
PQMSASVHLDSKKEQHLFVKEVKIDGQFRVSSFYAKGTYGLSCQRDPNTGRLNGESNLRF
NSSYLQGTNQITGRYEDGTLSLISTSDLQSGIIKNTASLKYENYELTLKSDTNGKYENFA
TSNKMDMTFSKQNALLRSEYQADYESLRFFSLLSGSLNSHGLELNADILGTDKINSGAHK
ATLRIGQDGVSTSATTNLKYSPLVLENELNAEIGLSGASMKLTTNGRFREHNAKFSLDGK
AALTELSLGSAYQAMILGVDSKNIFNFKISQEGLKLSNDMMGSYAEMKFDHTNSLNIAGL
SLDFSSKLDNIYSSDKFYKQTFNLQLQPYSLVTTLNNDLKYNALDLTNNGKLRLEPLKLH
MAGNLKGAYQNNEIKHIYTISSAALS-ASYKADT---VAKVQGVEFSHRLNTDIAGLASA
IDISTNYNSDSLHFSNVFHSVMAPFTMTIDTHTNGNGKLALWGEHTGQLYSKFLLKAEPL
AFTFSHDYKGSTSHHLMSRKSISTSLEHKVSALLTPAEQTGTWKLKTQFNNNEYSQDLDA
YNTKDKIGVELSGRALADLTLLDYPIEVPLLLSEPVNVIDALEMRDAVEKPQEFTIVAFV
KYDKNQDVHTINLPFFETLQEYFERNQRTIIVVLENMQRHLKRINIDQFVRKYRAALGKL
PQQANDYLNSFNWERQVSRAKEKLTALTKKYRITENDIQIALDDAKINFNEKLSQLQTYM
IQFDQYIKDNYDLHDLKIAIANIIDQIIEKLKSLDKHYHIRVNLVKTIHDLHLFIENIDF
NKIESSTASWIQNVDTKYQIRIRIQEKLQQLKRHIQNIDIQHLAGKLKQHIEAIDVRVLL
DQLGTTISFERINDVLEYVKHFVINLIGDFEVAEKINAFRAKVHELIERYEVDQQIQVLM
DKLVELAHQYKLKETIQKLSNVLQQVKIKDYFEKLVGFIDDAVKQLDELSFKTFIEDVNK
FLDMLIKKLKSFDYHQFVDETNNKIRELTQRLNGEIQALELPQKAEAL-KLFLQETKATV
AMYLESLQDTKITLIIDWLQDALSSASLAHMKAKFRETLEDTRDRIYQMDIEQELQRYLS
LVGQVYSTLVTYISDWWTLAAKNLTDFAEQYSIQDWAKHVKALVEQGFTVPEIKTILGTM
PAFEVSLQALQKATFQTPDFIVPLTDLRIPSVQINFKELKDIKIPSRFSTPEFTILNTFH
IPSFTIDFVEIKVKIIRTIDQMLNSELQWPVPEVYLRDLKVEDIPLARITLPDFHLPEIA
IPEFVIPNLNLNDFQVPDLHIPEFQLPHISHTIEVPTFGKLYSILKIQSPLFTLDANADI
GNGTT-SANEAGIAASITAKGESKLEVLNFDFQANAQLSNPKI--NPLALKEFVKFSSKY
LRTEHGSEMLFFGNAIEGKSNTVASLHTEKNTLELSNEVIVKINNQLTLDSNTKYFHKLN
IPKLDFSSQADLRNEIKTLLEAGHIAWTSSGKGSWKWACPRFSDEGTHESQISFTIEGPL
TSFGLSNKINSKHLRVNQNLVYESGSLNFSKLEIQSQVDSQHVGHSVLTAKGTALFGEGK
AEFTGRHDAHLNGKVIGTLKNSLFFSAQPFEITTSTNNEGNLKVSFPLRLTGKIDFLNNY
ALFLSPSAQQASWQVSTRFNQYKYNQNFSAGNNKNIMEAHIGINGEANLDFLNIPLTIPE
MP--LPYTTITTPP-LKDFSLWEKTGLKEFLKTTKQSFDLSVKAQYKKNTHRHSITNPLA
VLYEFTSQNIKSFDKHFEKARNNALGFVTKSYNDAKIKFDKYKAEKSHDELPRTFQIPGY
TVPV---VNVEVSPFTVEMSAFGYGIPKAVSMPSFTILGSNIRVPSYTLILP-SLELPVL
QVPRNL-KLSLPDFKELCTISHIFIPAMGNITFDFSFKSSVISLNTNAEVFNQSDIVAHL
LSSSSSVIDVLQYKLEGTTRLTRKRGLKLATALSLS-NKFVEGSHNSTVSLTKKNMEASV
ATTAKVQIPILRINFKQELNGNTKSKPTVSSSMEFKYDFNSSMLYSTAKGAVDHKLILES
L-----TSYFSIESSTKGDVKGSVLS-WDYSGTIASEANTYLNSKSTRSSVKLQGTSKID
DIWNLDVKENFAGEATLQRIYSLWEHSMKNHLKLEGLFFTNGEHTSKATLELSPWEMSAF
VQVHASQPNSFLDIPHLGQEVALNANTKNQKIRWKNEVRVHSGSFQNHVELSNDQEKAHL
DIAGSLEGHLRFLKNIILPVYGKSLWDFLKLDVTTSIGRRQHLRVSTAFVYTKNPNGYSF
SIPVKVLADEFI--IPGLKLNDLNSVLVMPTFHVPFTDLQVPSYKLDFREIKIYKKLRTS
SFALNLPALPEVKFPEVDVLTKYSQPEDSLIPFFEITVPESQLNVSQFTLPKSVSVGSAV
LDLNVVANKIADFELPTIIMPEQTIEIPSIKFSVPAGIFIPSFQALTARFEVDSPLYNAT
WRASLKNKADHVETVLDSTCSSTMQFLEYKLNVVGTHRIEDGMLASKTKGTFAHHDFSAE
YEEDGKYKGLREWERKVHLDIKSPAFTDLHLRYQKDKK-GISTSAASPAIGTMGMDV---
--DFSKWNI---YYS-PQSSPDKKLTIFKTELR--FRESDEEIQIKVNWEEEAAS-GLLT
SLKDNVPKATGALYDYVNKYHGEHTGLTLREASSKLRRNLQNNAEWVYQGAIRQIDDID-
-LRFQKAASGTTGTYQKWKDKAQNLYQELL-TQEGQTSFQGLKDKVFDGLVRVTQEFHTK
VKHLIDSLIDFLNFPRFQFPGKPGTYTGEELCTMFIREVGMVLSQVCLKVHNGSEILFSY
FQDLV----------ITLPFELRRHK---------LIDVISMCREWLK----VLSEEAQE
VFKDIQSLKT-TEVLRNLQDIL-QFIFQLIEGNIKELKEMKFTHLINYIQDGINTIFNDY
IPYVFKLLKENLCLNLHKFN----EFIQNELQGASQELQQIHQYIMALREEYFDPSVVGW
TVKYYELEEKIVRLIKNLLVALKDFHSEYIVSASDFTSQLSSQVEQFLHRNIQEYLSILT
DPDGKGKEKIAELSTTAQEIIKSQAIAMKEIISDYHQ

PF12491 // ENSGT00590000083139_0_Domain_6 (4658, 4716)

QFRYKLQDFSDQLSDYYEKFIAE
SKRLIDLSIQNYHTFLIYIMELLKKLQS-TTI--MNPYVKLAPGELTIIL----------
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-----------------------------------------------MGPQSPALR----
------LPLLLLLFLLLFLDTSVWAQDEVLENFS-LNCPKDATR

PF01347 // ENSGT00590000083139_0_Domain_0 (105, 673)

FKHLRKYVYNYEAESS
SGVRGTADSRSATKINCKVELEVPQLCSFIMRTSQCTLKEVYGFNPEGKALMKKTKNSDE
FAAAMSRFEL-KLAIPEGKQAVLYPDKDEPTHILNIKRGIVSALLVPPETAEDKQVL---
FLDTVYGNCSTQVTVNSRKGTVATEMSTERN----LQQCDGFQPISTSVSPLALIRGLVR
PLSTLVSSSQSC-QYTLDPKRKHISEAICSEQHLFLPFSYKNTYGIMTHVTQTLRLEDTP
--KTNSRFFSEG-TKRVGLSFESTKSTSPPKQ-VDAVLNTLQELKSLSVSEQNAQRANLF
NKLVTELRGLSDEAITSLLPQLIGVSS--PITLQALIQCGQPQCYTHILQWLKTEKAHPL
LVDIVTYLMALIPNPSTQRLREIFNTAKEQPSRATLYALSHVVNNYYD-ADHSRSPDL-Q
DIADYLLKQIDNECTGDEDHTYLILRVIGNMGRTMEQVMPALKSSVLNCVRSKKPSLQIQ
KASIQALRKMKLGDEVKEILFDTLMNGVDPVEKRLAAYLLLMKSPASSDISKIIQLLQWE
QSEQVKNFMASH

ENSGT00590000083139_0_Linker_0_3 (673, 709)

IANILNSEELYVQDLKKLIKDAPEYSQ-LPTIMDFK

PF09172 // ENSGT00590000083139_0_Domain_3 (709, 1017)

KFSRNYQISKSV
SLPSFD-PVSAKMEGNLIFDPNSYLPKESMLKTTLTVFGLASVDLFEIGLEGKGFEPTLE
ALFGQQGFFPDSVNKALYWVNGQVPDRVSKVLVDHFGYANNEKHEQDMVNGIMPMVDKLI
RELKSKEIPEARAYLRILGEELGFVKLQDLQVLGRLLLNGAQTLRGIPQMIA-QAIRDGS
NNDFFLHYIFMDNAFELPTGLGVQLQVSSSGVITPGTKAGVRMELA-NIQAELVAKPSVS
VEFVTNMGIIIPDFAKSGVQMNTNFFHESGLEARVALKAGQLKVIIPAPKKPVKLF

ENSGT00590000083139_0_Linker_3_5 (1017, 1044)

SGSN
TLHLVSTT----KTEVIPPLIEN

PF06448 // ENSGT00590000083139_0_Domain_5 (1044, 1156)

RQSWSTCKPFFTGMNYCTTG-AYSNASSTESASYYPL
TGDTRYELELKPTGEVEQYSASATYELQKEDKSLVDTLKFLVQAEGVQQTEATAVFKYNR
RSRTLSSEVLIPGFD

ENSGT00590000083139_0_Linker_5_6 (1156, 4658)

VDFGTILRVNDESSKDKNAYKLILDIQNKKITEVSLVGHVSYDKK
GDGKIKGVVSVPHLQAEARSEIHTHWSPTKLLFQIDSS--ATAYGSTISKRVVWRYDNEK
IEFDWNAGTNVDTKKVASNFPV----DLSSYPRTLHEYANSLLDHRVPQTDMTFRHMGSK
VIVATNTWLQMASRGLPYSQILQDHLNGLSELNLQKMGLPDFHIPDNLFLKSDGRIKYTL
NKNSIKLDIPLPLGGKSSKDLKIPERVRTPDLNFKFMGFHLPSQVFQVPTFTIPKTYQLQ
VPLLGVLDLSTNVYSNLYNWSASYTGSNTSR-D--HFSLWAQYRMKADSAVDLFSYSMQG
SGETTYDSRSTFTLSCDWSLHHKF-LDSKFKVSHVEKFGNTPVSKGL---LTFEASSAWG
PQMSATVHLDSEKKQQLYVKHIKVDGQFRASSIYAQGKYGLSCERNPTTGQLSGESNMSF
NSTYLQGTNQIVGIYQDGTLSLTSTSDLQDGIFKNTASLKYENYELTMKSDSSGHYENFA
ASNKLDMTFSKQSASLRSEHQANYKSLRLVTLLSGSLTSQGMELNADILGTDKMNSGAHK
ATLKITRDGLSTSATTNLKYSPLLLENELNAELGLSGASMKLSTNGRFKEHHAKFSVDGK
AALTEVSLGSIYQAMILGADSKNIFNFKLSREGLKLSNDLMGSYAEMKLDHTHSLSITGL
SLDLSSKMDNIYSADKFYKQNFNVQLQPYSFLTTLSNDLRYNVLDLTNSGKLQLEPLKVN
VGGNFKGVYQNNELKHIYAISYTDLVVASYRADT---VAKVQGIEFSHRLNADIEGLASS
VDVTTYYNSDPLHFNNVFHFVLAPFTLGIDTHTSGDGKLSLWGEHTGQLYNKFLLKAEPL
ALAFSHDFKGSTNHDLVYKNSISTALDHSFGALLTPAEQTSTWKFKTRLNDKVYSQDFEA
YNTKDKIGVDLSGR--AELSGLYSPFKVPFFHSEPVNVLSDLEINDAEDKPQEFTIVAFV
KYDKNQDVHTISLPFFKSLPEYLERNRRGIITLLEAMQGELQRINIDQFVRKYKAALSRL
PQQIRDYLNASDWERQVTNAKEKLTAFMENYRITDNDVLIALDSAKINFNEKLSQLETYV
IQFDQYIKDNYDPQYFKKTIAQIIDRIIEKLKILDEQYHIRVNLEKSIHNLYVFVENVDL
NKIGSSTASWIQNVDTKYQVRIQIQEKLQQLRTQIQTIDIQQLATELKQQIETIDFTMHL
DQLRTAILFQRVNDIIERVKYFVMNLIEDFKVTEKINTFRAIVHELIEKYEVDRQIQVLM
DKSVELAHRYSLGETLQKLSNVLQQIEIKHYYEKFVGFIDDTVKWLKALSFKNYIEELNR
FLDMLVKKLKAFDYHQFIDETNSKIREVTQRINAEIQALELPQKTEAL-KLLVEGFKATV
SNYLERLKDTKVTVFIDWLQGAL-----VHIKAHFQDTLEDVRDRLYQMDIQWEFEHFLS
LVSQVYNTLVTYISDWWSLTAKNITDFAEQYSIQNWAETVKLLVEQGFTVPEIQTFLGTM
PAFEISLRALQEANFQTPDFIVPLTDLRIPSIRINLKMLKNVKIPSRFSTPEFTLLNTFH
VRSFTIDLLEIKAKIIRTIDQMLNSEIQWPLPEVYLRDLEIVNISLARLTLPDFHVPEMT
IPEFTIPNVNFKEFRVPDLHIPEFQLPHLSHTIEMPAFGKLHGILKIQSPLFILDANANI
QNVTT-SENKAEIMASITATGESKFEALNFDFQAQAQFLELTP--NPLVLKESMNFSSKH
VRMEHEGEILFSGKSIEGKLDTVASLHTEKNMVEFNNGMIVRLNNQLTLDSHTKYFHKLS
IPRLDFSSKASFNNEIKTLLEAGHVAWTSSGTGSWNWACPNFSDEGTHSSRISFTVEGPI
ASFGMSNNINGKHLRVIQKLAYESGFLNYSKLEVESKVESQHVGSSILTGKATVLLREAK
AEMTGEHNAELNGRVIGTLKNSLYFSAQPFMITASTNNDGNLKVSFPLKLTGKIDFLNNY
ALFLSPHAQQASWQASARFNQYKYNQNFSAINNEHNMETHIGMNGDANLDFLNIPLTIPE
MN--LPYIGLTTPL-LKDFSIWEETGLKEFLKTTKQSFDLSVKAQYKKNRDKHSIAIPLS
GFYEFILNKVNSWDRKFEKVRDSALDFLTASYNEAKNKFE-----NSLIQPPRTFQSRGY
TIPF---VNIEVSPFTVETLASSHVIPKAISTPSVTIPGPNVIVPSYRLVLP-SLELPVF
HAPRNLLKFSLPAFKELKTIDNIHIPALGNFTYDFSFKSSVITLNTNAGLYNRSDIIAHF
LSSSSFVTDALQYKLEGTSRLTQKRVSKLATAISLT-NKFVKGNHDSTISLTKKNMEALV
KTTANLHVPILTMNFKQELNGNTKSKPTVSSSIELNYDFNSSKLHSTAKGGVNYKFSLES
L-----TSYFSIESSTKGNIKGSVLS-QEYSGSVTSVANTYLNSKGTRSSVSLQGASKVD
GVWNLEVEENFAGEATLQRIYATWEHNNNNYFQVDSFFVTKGKQTYRATLELSPWTMSTL
LQVHMSQPSSLLDLHHFDQEVTLKANTKNQKVNWKSEVQIHSQVLRHNVQFSNDQEEVRL
DIAGSTDGQLWDLETIFLPVYDKSLQELLQMN-----GKRQYLQASTSIVYTKNPNGYLF
SLPVQELADQFI--IPGLKLNN-------------------------FNGIKIYKKLSTS
PFALNLTMLPKVNFPGVDVLTQYSKPEGSSVPTFQVTIPEVQLTVSQFTLPK------TG
FDLNEIANRIAEVDLPSITLPEQTIKVPPFKFSVPSGILIPFFGALTAQVGVASPVYNAT
WSAGLKNKADHVETFLDSTSSSIWQFLEYELKVVGTHKIEDHMFICKNKGTLQHRDFNVE
YNEDGVFKGLWVWQGEARLDITSPALTELRLLYKEDET-SLSASVASPAIGIVGLESSTD
Y-HSVKLNV---YFY-PQVGPNRKLSIFKTEWR--CKKNDDGMHIKINWEEEAAS-RLLG
SLKSNVPKATEALYDYVNKNYLGNT-------SLELRRSLQNNVES----AIRTIDAMN-
-MDFQRAAH---D--------TQNLYEEML-AQEGQSIPERLQEKALDSLVHVTQMYHKE
VMFLTDSFIRFLKYNTFHLPGNAGTYTTDELCTLVMGETAKLLSR----IHNSLEKLLSY
VQDLVEKSSLISDMELKFPFISKTRT---------LKDAILEYRNIIN----TLQ-----
------NTKF-TTILSELQGFL-DRILDIIVEQIQCLSD--NACFTDYINA-V---FKIN
VPDAFKFLREDLYAIFREFH----DSAQSILQEGSYKLQQAYQYIKALREEYFDPSMVGW
TVKYYAVEEKMVDLIKSLLVILRDFHSKYSARATDFDSKITTQVEQFMSRDMQEYLSILI
DINGKGKEKIAKLSIMAKEAFKNWATAMKETISDYQE

PF12491 // ENSGT00590000083139_0_Domain_6 (4658, 4714)

QFSFKLQDFSVQLSEYFEKFLAE
STRLIDLSIQSYHVFLRYITELLKELQV-ATTNNVSPYINRAPGELVITF----------
------------------------------------------------------------
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--------------------------