Query Results 

---------------------------------MPNEGIPHSSQTQEQDCL-----QSQP
VSNNEEMAIKQESG-G--G-GEVEEYLSFRS---VGDGLSTSAVGCASAAPRRGPALLHI
DRHQIQAVEPSAQALELQGLGVDVYDQDVLEQGVLQQVDNAIHEASRASQLADVEKEYRS
VLDDLTSCATSLRQINKIIEQLSPQAATSRDINRKLDSVKRQKYNKEQQLKKITAKQKHL
QAILGGAEVK--IELDHASLE--EDAEPG----PSSLGSMLMPVQETAWEELIRTGQMTP
FGTQIPQKQEKKPRKIMLNEASGFEKYLADQA--KLSFERKKQ-ACNKRAARKTPAPVTP
-PAPVQ----N--KPNKKARVLSKKEERLKKHIKKLQKRAL--QFQGKVGLPKARRPWES
DMRPEA-EGDSEGEESEYFPTEEEE--EEEDDEVEGAEADLSGDGTDYELKPLPKGGKRQ
KKVP---VQEIDDDFFPSSGEEAEAASVGEG---GGGGRKVGRYRDDGDEDYYKQRLRRW
NKLRLQDKE-KRLKLEDDSEESDAEFDEGFKVPGFLFKKLFKYQQTGVRW

PF00176 // ENSGT00590000083118_2_Domain_0 (591, 898)

LWELHCQQAG
GILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRFEGLGPTVIVCPTTVMHQWVKEFHT
WWPPFRVAILHETGSYTHKKEKLIRDVAHCHGILITSYSYIRLMQDDISRYDWHYVILDE
GHKIRNPNAAVTLACK-----QFRTPHRI---IL--SGSPMQNNLRELWSLFDFIFPGKL
GTLPVFMEQFSVPITMGGYSNASPVQVKTAYKCACVLRDTINPYLLRRMKSDVKMSLSLP
DKNEQV--LFCRLTDEQHKVYQ--NFVDSKEVYRILNGEMQIFSGLIALRKICNHPD

ENSGT00590000083118_2_Linker_0_1 (898, 935)

LFS
GGPKNLKGLPDDELE-EDQFGYWKRSGKMIVVES

PF00271 // ENSGT00590000083118_2_Domain_1 (935, 1040)

LLKIWHKQGQRVLLFSQSRQMLDILE
VFLRAQKYTYLKMDGTTTIASRQPLITRYNEDTSIFVFLLTTRVGGLGVNLTGANRVVIY
DPDWNPSTDTQARERAWRIGQKKQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVLKDPKQ
RRFFKSNDLYELFTLTSPDASQSTETSAIF----------------------------AG
TGSDVQTPKCHLKRRIQPAFGAD--HDV---------PKRKKFPASNMSVNDAT-SS---
---EEKSEAKGAEVNAVTSNR--SDPLK-DDPHMSSNVTSN-DRLGEET----NAVSG--
-PEELSVISGNGECSNSSGTGKTSRPSGDESI-DEKLGLSYKREGPSQAQTEAFWENKQM
ENNFYKHKSKTKHHSVAEEETLEKHLRPKQKPKNSKHCRDAKFEGTRIPHLVKKRRYQKQ
DSENKSEAKEQSNDDYVLEKLFKKS-VGVHSVMKHDAIMDGASPDYVL---VEAEANRVA
QDALKALRLSRQRCLGAVSGVPTWTGHRGISGAPAGKK--SRFGKKRNSNFSVQHPSSTS
PTEKCQDGIMKKE---GKDNVPEHFSGRAEDADSSSGALASSSLLAKMRARNHLILPERL
ESESGHLQEA--SALL-PTTEHDDLLVEMRNFIAFQAHTDGQASTREILQEFESKLSASQ
SCVFRELLRNLCTFHRTSGGEGIWKLKPEYC

---------------------------------MPNEGIPHSSQTQEQDYL-----QSQL
VSNNEEMAIKQESG-G--D-GEVEEYLPFSS---VGDGLSTSAEGCASAAPRRGPALLHI
NRHQIQAVEPSAQALELQGLGVDVYDQDVLEQGVLRQVDNAIHEASRTSQLADVEKEYRS
VLDDLTSCTTSLRQINKIIEQLSPQAATSRDINRKLDSVKRQKYNKEQQLKKITAKQKHL
QAILGGAEVK--IELDHASLE--EDAEPG----PSSLGSMLMPVQETAWEELIRTGQMTP
FGTQIPQKQEKKPRKIMLNEASGFEKYLADQA--KLSFERKKQATYNKRPARKAPASVTP
-PAPTQ----SKNKPNKKAKVLSKKEERLKKHIKKLQKRAL--QFQGKVGLPKARRPWES
DMRPEA-EGDSEGEESEYFPTEEEE--EEEDDEVEGVEADLSGDGTDYELKPLPKGRKRQ
KKVP---VQEIDDDFFPSSGEEAEASPIGEG---GGGSRKVGRYRDDGDEDYYKQRLRRW
NKLRLQDKE-KRLKLEDDSEESDAEFDEGFKVPGFLFKKLFKYQQTGVRW

PF00176 // ENSGT00590000083118_2_Domain_0 (591, 898)

LWELHCQQAG
GILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRFEGLGPTVIVCPTTVMHQWVKEFHT
WWPPFRVAILHETGSYTHKKEKLIRDVAHCHGILITSYSYIRLMQDDISRYDWHYVILDE
GHKIRNPNAAVTLACK-----QFRTPHRI---IL--SGSPMQNNLRELWSLFDFIFPGKL
GTLPVFMEQFSVPITMGGYSNASPVQVKTAYKCACVLRDTINPYLLRRMKSDVKMSLSLP
DKNEQV--LFCRLTDEQHKVYQ--NFVDSKEVYRILNGEMQIFSGLIALRKICNHPD

ENSGT00590000083118_2_Linker_0_1 (898, 935)

LFS
GGPKNLKGLPDDELE-EDQFGYWKRSGKMIVVES

PF00271 // ENSGT00590000083118_2_Domain_1 (935, 1040)

LLKIWHKQGQRVLLFSQSRQMLDILE
VFLRAQKYTYLKMDGTTTIASRQPLITRYNEDTSIFVFLLTTRVGGLGVNLTGANRVVIY
DPDWNPSTDTQARERAWRIGQKKQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVLKDPKQ
RRFFKSNDLYELFTLTSPDASQSTETSAIF----------------------------AG
TGSDVQTPKCHLKRKIQPAFGAD--HDV---------PKRKKFPASNISINDAT-SS---
---EEKSEAKGAEVNVVPSNQ--SDPLK-DDPHMSSNIASN-DRLGEET----NAVSG--
-PEESSVISGNGECSNSSGTGKTSRPSGDESI-DEKLGLSYKRERPSQARTESFWENKQM
ENNFYKHKSKTKHHSVAEEETLEKHLRPKRKPKNPKHCRDAKFEGTRIPHLVKKRRYQKQ
DSENKSEAKEQSNDDYVLEKLFKKS-VGVHSVMKHDAIMDGASPDYVL---VEAEANRVA
QDALKALRLSRQQCLGAVSGVPTWTGHRVISGAPAGTK--SRFGKKRNSNFSVQHSSSTS
PTEKCQDGIMKKE---GKDNVPEHFSGRAEDADSSSGALASSSLLAKMRARNHLILPERL
ESESGHLQEA--SALL-PTTEHDDLLVEMRNFIAFQAHTDGQASTREILQEFESKLSASQ
SCVFRELLRNLCTFHRTSGGEGIWKLKPEYC

---------------------------------MPNERIPHSSQTQEPDCS-----RSQD
VSGSEEGTIKQEKD-G--D-MDLGQSLPSCS---SANGPSTSTEGCLLELPRRGPALLHI
DRHQIQAVEPGAQALELQGLGVDVYDQDVLEQGVLQQVDSAIHEASCVAQLAEAEKEYRS
VLDDLTSCTTSLRQIDKIIEQLGPQAATNKDINRKLDSVKRQKYNKEQQLKKITAKQKRL
QAVLGGAEVQ--VELGLGGLEE-EDAEAE----PSCLGSMLMPAQETAWEELVRTGQMTP
FGTKIPQKQEKKPRKLMLNEASGFEKYLADQA--KLSFERKKQ-ACNKRAAKKASASATS
EPSSAL----NENKPDERGKAVSKTDKRLKKQIKKLQKRAL--QLQGQVGLLKGKKPWDC
DVRPNA-QGDSEDEESEYLPTEEELE--------ETVGADLPGEGSDWEQRLVLNRRKRQ
KKVT---VQEIDDDFFPSSGEEAEA-------T--GGGRKVVRCRDDGDEDYYKQRLSRW
SITRLKQDKASLPWLDDITNSMDMNLSHGVRMPKIMRKSLYKYREKDNVFPGDIRCAQGA
WELGDSTGHADAQRILAFLMKTSFKRLR

PF00176 // ENSGT00590000083118_2_Domain_0 (629, 897)

VRGVYALFEGLGPTIIVCPTTVMHQWVKEFHT
WWPAFRVAVLHETGSFTHKKEKLVRDIARCHGILITSYSYIRLMQDDISRHDWHYVILDE
GHKIRNPNAAVTLACK-----QFRTPHRI---IL--SGSPMQNNLRELWSLFDFIFPGKL
GTLPVFMEQFSVPITMGGYSNASPVQVKTAYKCACVLRDTINPYLLRRMKSDVKMSLSLP
DKNEQV--LFCRLTDEQHKVYQ--NFIDSKEVYRILNGEMQIFSGLVALRKICNHP

ENSGT00590000083118_2_Linker_0_1 (897, 962)

DLFS
GGPKNLKGIPDEELG-EDQFGYWKRSGKMIVVESLLKIWHKQGQRVLLFSQSRQMLDILE
V

PF00271 // ENSGT00590000083118_2_Domain_1 (962, 1040)

FLRAQKYSYLKMDGTTAIASRQPLITRYNEDTSIFVFLLTTRVGGLGVNLTGANRVIIY
DPDWNPSTDTQARERAWRIGQKKQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVLKDPKQ
RRFFKSNDLYELFTLSSPDTSQSTETSAIF----------------------------AG
TGSDVQTPKRHLKRRLQQACGTD--QSV---------PVDRQFPDCKTSASAAM-SS---
---EEVCAASVSEVNAVTSDQ--GIPLN-DAVQTPHSLTSS-ERLGEEA----DAVSR--
-PRESSVIHGNGNSSDSPRVSRTCGVSGEESV-SEKESLSDKRES-CQVQREALWENEQT
ENNFYKHKSKMKH-HVAEE-PMEKHLRPNQKPKSSKHRRDAKFEGTRIPHLVKKRQYRRR
DPAAESEAKERSHDDYVLEKLFRKS-AGVHSVMKHDAIMDGASPDHVL---VEAEANRVA
QDALRALRLSRQQCLGAASGVPTWTGHRVLAGAPAGKK--SRFGQKRNSSFSVQRPSSTS
PKEKCQDSTVKKE---GKDHVSEHFSGKAEDTESSSGALTSSSLLAKMRARNHLILPERL
ESESGRLPEA--AAPLPCSTEHDDLLVEMRNFIAFQAQADGQASTREILQEFESKLSASQ
SCVFRELLRSLCTFHRTSAGEGIWKLKPEYC

---------------------------------MPSEGSPHSCQTQEQERL-----QSLT
VRADEETRM--EQEHG--GAVEVGERLPSPPSAQSDTGPSTSAEGCTSAAVRRGPALLHI
DRHQIPAVEPNAQALELQGLGVDVYDQAVLEQGVLQQVDSALHEASRVAQLIDAEKEYQS
VLDDLASCTTSLRQIDKIIEQLSPQAATNRDINRKLDSVKRQKYNKEQQLKKITAKQKRL
QAILGGAAVR--VELDHNSLKEE-DAEPG----PSCLGSMLMPAQETAWEELIRTGQMTP
FGTQIPQKTEKKPRKLMLNEASGFEKYLADQA--KLSSERKKQ-AANKRASRKAPASVKS
EPSARS----KENKPKQKNKVLLKTDRRLKKHIRKLQKRAL--QFQGKVGLPRGKRSLEV
EVRPQ-AEGDSEGDEPRSCPTEG-----EEEGDREEVGASLSGDGADCELRPVLRGHKHQ
KKVP---VRESDDDFFPSSGEETEA--TE---DRGRPSRKIVRCRDDGDGEYYKQRLRRW
NKLRLRDKE-KRLKLEDDSEESDAEFDEGFKVPGFLFKKLFKYQQTGVRW

PF00176 // ENSGT00590000083118_2_Domain_0 (591, 898)

LWELHCQQAG
GILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRFEGLGPTMIVCPTTVMHQWVKELHT
WWPPFRVAILHETGSYTHRKEKLIRDIAHCHGILITSYSYVRLMQDDLSRHDWHYVILDE
GHKIRNPNAAITLACK-----QFRTPHRI---IL--SGSPMQNNLRELWSLFDFVFPGKL
GTLPVFMEQFSVPITMGGYANASPVQVKTAYKCACVLRDTINPYLLRRMKSDVKMSLSLP
DKNEQV--LFCRLTDEQHKVYQ--NFIDSKEVYRILNGEMQIFSGLVALRKICNHPD

ENSGT00590000083118_2_Linker_0_1 (898, 935)

LFS
GGPKNLGSLPDNELE-EDQFGYWKRSGKMIVVES

PF00271 // ENSGT00590000083118_2_Domain_1 (935, 1040)

LLKIWHKQGQRVLLFSQSRQMLHILE
VFLRAQRYSYLKMDGSTTIASRQPLIARYNEDASIFVFLLTTRVGGIGVNLTGANRVIIY
DPDWNPSTDTQARERAWRIGQKRQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVLKDPKQ
RRFFKSNDLYELFTLTSPDASQSTETSAIF----------------------------AG
TGSDVPTPKRHLKRKILPAFGTD--HDV---------PKCKKFPDSNTLANVTA-SA---
---EDKSKAAG---PEVTSSA--GSPLK-GDPKPGGRVTVG-DGVREET----SAVSG--
-PEEPPVTSGNGNCSNSPQIGRAPGPSGEESA-AAKQGPSCDGDS-SQVPAEPPWENGQV
RSPSCKHKSKTKHQGVVEEGDLEK----QQKPESTKHCRDAKFEGTRVPHLVKRRRYHRH
DTDPETEARARSGDDYVLEKLFKKS-VGVHSVVKHDAIMDGANPDYVL---VEAEANRVA
QDALKALRLSRQQCLGALSGVPTWTGHRGT-----GVK--SRFGQKRNSNLSVQCTSSSS
STEKCQDGVVKRE---GKERASEHFSGKAEDTDSSSGAPTSSSLLARMRARNHLILPERL
ESENGHIPEV--SAPPPHTTEHDDLLVEMRNFIAFQARVDGQASTREILQEFESKLSAAQ
SCVFRELLRNLCTFHRTPSGEGVWRLKPEYC

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---------------------------------------MLMPVQETEWEELIRTGQMTP
FGTKVPQKIEKKPRRLMLNETSDFEKYLADQA--KLSSERKRS-ALKKRAKNRAELKKAQ
CALPTL----VKKEKRGKTRILSKTDKRLKKHMKKLQTHAL--QIQFKIGIPKEKRLPEL
QERLKG-EQGDESGESEYVPDEELFNPEDEEE----EPFSLADDSSDYELKTLPGARKHS
GKRILKEEAEEDEDFFPSSEEEEEEST--------IGNRRVKRCRDDGDEDYYKQRLRRW
HKQRLKDKE-RRRMAEEDSDESDAEFDEGFRVPGFLFRKLFK

PF00176 // ENSGT00590000083118_2_Domain_0 (583, 897)

YQQTGVRWLWELHCQQAG
GILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRFKGLGPTVIVCPATVMHQWVKEFHT
WWPPFRVAVLHETGSYTNKKVKLIREIATCHGILITSYSYIRLMQDHINNYDWHYVILDE
GHKIRNPNAAITLACK-----QFRTPHRI---IL--SGSPMQNNLKELWSLFDFVFPGKL
GTLPVFMEQFSVPITMGGYSNASPVQVKTAYKCACVLRDTINPYLLRRMKADVKMSLSLP
DKNEQV--LFCRLTDEQRQVYQ--NFIDSKEVYQILNGEMQIFSGLVALRKICNHP

ENSGT00590000083118_2_Linker_0_1 (897, 962)

DLFS
GGPKLLKGVPDDELEEADNFGYWKRSGKMIVVESLLKIWHKQGHRVLLFTQSRQMLRILE
V

PF00271 // ENSGT00590000083118_2_Domain_1 (962, 1040)

FLRDRNYSYLKMDGTTTIASRQPLIMSYNQDTSIFVFLLTTRVGGIGVNLTGADRVIIY
DPDWNPSTDTQARERAWRIGQKKQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVLKDPKQ
RRFFKSNDLYELFTLTSPDGCQGTETSAIF----------------------------AG
TGSDVQAPKRQLKRKPEKPLDC--ASKHDLHLKEHDSPKYDKPTDSSSASHLMNS-S---
---KAIEPVGEIKGNLETFNQ--NSSVK-DGTQATNNIDSL--IEEEEKSMRPSEGSVFQ
ALPGNAQTSENVQCSNPTLTGEMHRAPSIPV--GSRHSLICEADS-SQGKQNGNLEDEQL
VNNPHKCTSKTKHGI-----AMQALESHRGTSKKPKHHKGARFEGERIPYLMKQKQYRKG
NQEEE--EEQKKNDDYVLEKLFKKS--GIHSVMKHDVIMEASNPDYVL---VEAEATRVA
QDALRALKISRQRCLGAASGVPTWTGNSALTGAPSRLK--SRFGQKRNPTLLIPHSSTTS
RGKKCKDADITRKEKAKKNTPSVHFDGKIET-ESSSSALDSSSLLAKMRARNHLILPQTM
ENESDETLQ--ASAPLPTSTEHDELLVDVRNFIAFQARVDGEASTQEILQEFESKLSMAQ
SCVFRELLRNLCTFHRSPNGEGVWKLKPEFR

---------------------------------MPNEGIPHSSQTQEQDYL-----QSQP
VSNNEEMAIKQESG-G--D-GEVEEYLPFSS---VGDGPSTSAEGCASAASRRGPALLHI
NRHQIQAVEPSAQALELQGLGVDVYDQDVLEQGVLRQVDNAIHEASRTSQLADVEKEYRS
VLDDLTSCTTSLRQINKIIEQLSPQAATSRDINRKLDSVKRQKYNKEQQLKKITAKQKHL
QAILGGAEVK--IELDHASLE--EDAEPG----PSSLGSMLMPVQETAWEELIRTGQMTP
FGTQIPQKQEKKPRKIMLNEASGFEKYLADQA--KLSFERKKQATCNKRPARKAPASVTP
-PAPTQ----SKNKPNKKAKVLSKKEERLKKHIKKLQKRAL--QFQGKVGLPKARRPWES
DMRPEA-EGDSEGEESEYFPTEEEEEEEEEDDEVEGVEADLSGDGTDYELKPLPKGRKRQ
KKVP---VQEIDDDFFPSSGEEAEASPIGEG---GGGGRKVGRYRDDGDEDYYKQRLRRW
NKLRLQDKE-KRLKLEDDSEESDAEFDEGFKVPGFLFKKLFKYQQTGVRW

PF00176 // ENSGT00590000083118_2_Domain_0 (591, 898)

LWELHCQQAG
GILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRFEGLGPTVIVCPTTVMHQWVKEFHT
WWPPFRVAILHETGSYTHKKEKLIRDVAHCHGILITSYSYIRLMQDDISRYDWHYVILDE
GHKIRNPNAAVTLACK-----QFRTPHRI---IL--SGSPMQNNLRELWSLFDFIFPGKL
GTLPVFMEQFSVPITMGGYSNASPVQVKTAYKCACVLRDTINPYLLRRMKSDVKMSLSLP
DKNEQV--LFCRLTDEQHKVYQ--NFVDSKEVYRILNGEMQIFSGLIALRKICNHPD

ENSGT00590000083118_2_Linker_0_1 (898, 935)

LFS
GGPKNLKGLPDDELE-EDQFGYWKRSGKMIVVES

PF00271 // ENSGT00590000083118_2_Domain_1 (935, 1040)

LLKIWHKQGQRVLLFSQSRQMLDILE
VFLRAQKYTYLKMDGTTTIASRQPLITRYNEDTSIFVFLLTTRVGGLGVNLTGANRVVIY
DPDWNPSTDTQARERAWRIGQKKQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVLKDPKQ
RRFFKSNDLYELFTLTSPDASQSTETSAIF----------------------------AG
TGSDVQTPKCHLKRKIQPTFGAD--HDV---------PKRKKFPASNISINDAT-SS---
---EEKSEAKGAEVNVVPSNQ--SDPLK-DDPHMSSNIASN-DRLGEET----NAVSG--
-LEESSVISGNGECSNSSGTGKTSRPSGDESI-DEKLGLSYKRERPSQAQTESFWENKQM
ENNFYKHKSKTKHHSVAEEETLEKHLRPKQKPKNPKHCRDAKFEGTRIPHLVKKRRYQKQ
DSENKSEAKEQSNDDYVLEKLFKKS-VGVHSVMKHDAIMDGASPDYVL---VEAEANRVA
QDALKALRLSRQRCLGAVSGVPTWTGHRGISGAPAGTK--SRFGKKRNSNFSVQHSSSTS
PTEKCQDGIMKKE---GKDNVPEHFSGRAEDADSSSGALASSSLLAKMRARNHLILPERL
ESESGHLQEA--SALL-PTTEHDDLLVEMRNFIAFQAHTDGQASTREILQEFESKLSASQ
SCVFRELLRNLCTFHRTSGGEGIWKLKPEYC

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-SSTFTRRLLMT---TALHS

PF00176 // ENSGT00590000083118_2_Domain_0 (681, 882)

VKLIHEIAGCQGILITSYSYIRLMQDNINNYDWHYVILDE
GHKIRNPNAAVTLACKQ---QQFRTPHRI---IL--SGSPMQNNLRELWSLFDFVFPGKL
GTLPVFMEQFSVPITMGGYSNASPVQVKTAYKCACVLRDTINPYLLRRMKADVKMSLSLP
DKNEQ------------------------------------

ENSGT00590000083118_2_Linker_0_1 (882, 962)

IFPGLMALRKMCNHPDLFS
GGPKILKNVPDDELEEEDQFGYWKRSGKMIVVESLLKIWHKQGHRVLLFSQSRQMLHILE
V

PF00271 // ENSGT00590000083118_2_Domain_1 (962, 1040)

FLRGQKYSYLKMDGTTTIASRQPLITRYNEDTSIFVFLLTTRVGGIGVNLTGANRVIIY
DPDWNPSTDTQARERAWRIGQKRQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVLKDPKQ
RRFFKSNDLYELFTLSNPDGSQGTETSAIF----------------------------AG
TGSDVPAPKRHLKRKLQGPPAGSCQDRR---------PTD---PESSDGTKEPVPSPAR-
-QSRAHSSAQETEVNSEAFRA--GGPLI-VGAPTNT------NGLSGENSKQTDLASA--
-LEDRAPIPEHGEHSSPPRLGEAHGASSGGKA-EEEQNLPRDGTA-SQVKPDAKSESERV
ENHFQKHKSKMKHHIEEG-EEPLKSEGRAPRPKKSKHPKDAKFEGTRVPHLVKQKRYRKR
VREDEKEEDAKKNDDYVLEKLFKKS-----------------------------------
------------------------------------------------------------
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-------------------------------

---------------------------------MFHEEVPNSTHPQEQDCL-----PSQH
ANAYKDMPVGQEDG-G--V-SEAGECLSSTS---CEYGPSTSAEACVLAATRRGPTLLHI
DRHQIPAVEPSAQALELQGLGVDVYDQAVLEQGVLEQVDSAMHEASRVAQLADAEKEYQS
VLDDLMSCTTSLRQINKIIEQLSPQAASSRDINRKLDSVKRQKYNKEQQLKKITAKQKRL
QAILGGAGVQ--VELDHASLEE-DDAEPG----PSCLGSMLMPAQETAWEELIRTGQMTP
FGTPAPQKQEKKPRKIMLNEASGFEKYLAEQA--QLSFERKKQ-AATKRTAKKAV--VIS
ESSRAA----NETKADQRSQVLSQTDKRLKKHSRKLQRRAL--QFQGRVGLPSGKKPLEP
EVRPEA-EGDTEGEESGSSPTDGEEEEEQEE---EEAVASLSSDDVSYELKPLRKRQKYQ
KKVP---VQEFDDDFIPSSEEEDEAME------GRGGGRKVARRQDDGDEDYYKQRLRRW
NRLRLQDKE-KRLKLEDDSEESDAEFDEGFKVPGFLFKKLFKYQQTGVRW

PF00176 // ENSGT00590000083118_2_Domain_0 (591, 898)

LWELHCQQAG
GILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRFEGLGPTIIVCPTTVMHQWVKEFHT
WWPPFRVAVLHETGSYAHKKERLIRDIVYCHGVLITSYSYIRLMQDDISRHDWHYVILDE
GHKIRNPNAAVTLACK-----QFRTPHRI---IL--SGSPMQNNLRELWSLFDFIFPGKL
GTLPVFMEQFSVPITMGGYSNASPVQVKTAYKCACVLRDTINPYLLRRMKSDVKMSLSLP
DKNEQV--LFCRLTDEQHKVYQ--NFIDSKAVYRILNGENQIFSGLVALRKICNHPD

ENSGT00590000083118_2_Linker_0_1 (898, 936)

LFS
GGPKSVSGLPEGELE-EEQFGHWRRSGKMIVVESL

PF00271 // ENSGT00590000083118_2_Domain_1 (936, 1040)

LKIWHRQGQRVLLFSQSRQMLHILE
VFLRAHKYSYLKMDGTTTIASRQPLITKYNEDTSIFVFLLTTRVGGLGVNLTGANRVIIY
DPDWNPSTDTQARERAWRIGQKKQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVLKDPKQ
RRFFKSNDLYELFTLTSPDASQGTETSAIF----------------------------AG
TGSSIQTPKCHLKKKTSPGLRTD--------------PKCKKAPASNIPANAAT-LI---
---GEKPKAAGATGRSVTSGE--SGPFK-GDHDTNGNRASS-VAFGEET----DAGST--
-LEHLSVMSGDGKHSDSPTVNHTSRPPVEAST-SEKQGSSYEGEC-CQAQTEPVRMSEQM
EGQFCKYKSKRKH-DASEEETTEKCPQPKRKAKNSKHCRDAKFEGTRVPHLVKKRRYRQQ
TSEQEGGAKDRSSDDYVLEKLFKKS-VGVHSVVKHDAIIDGSSPDYVL---VEAEANRVA
QDALKALRLSRQQCLGAASGVPTWTGHRGISGAPTGVK--NRFGQKRNSSLPVQRPSS--
LTEKTQNN-MKKE---GKAYTPEHFSGKEDGA-SLSGAPSSSSLLARMRARNHMILPERL
ESDSEHLAEA--AAVPPCGTEHDDLLVDMRNFIAFQAQVDGQASTQEILQEFESKLSVAQ
SCVFRELLRNLCNFHRTPGGEGIWKLKPEYC

---------------------------------MPNERIPHSNQPQEQECV-----QSQC
VSSNEDMAIKQERD-G--S-VEGEGSLPSCS---SANGPSASAEGCPSEVPRRGPALLHI
DRHQIQAVEPSAQALELQGLGVDVYDQDVLEQGVLQQVDSAIHEASCAAQLADAEKEYRS
VLDDLTSCTTSLRQINKIIEQLSPQAAANRDINRKLDSVKRQKYNKEQQLKKITAKQKRL
QAILGGAEVN--IELDHAGLEE-EAAEPG----PSSLGSMLMPVQEAAWEELIRTGQMTP
FGTQIPQKQEKKPRKLMLNEASGFEKYLADQA--KLSFERKKQ-ACNKRAARKAPAPVTS
ELIPTL----SENKPDERSRVLSKADKRLKKRIGKLQKRAL--QFQGKVGLLKRRKPWES
DVRPKA-EGDSESEESEYLPTEEEQD--------EAAGADLSGEGTDCELRPVLKRPKWP
KKVT---VQEIDDDFFPSSGEEAEATG-----G--GGGRKVVKCRDDGDEDYYKQRLRRW
NKLRLQNKE-KCLKLEDDSEESDAEFDEGFKMPGFLFRKLFK

PF00176 // ENSGT00590000083118_2_Domain_0 (583, 921)

YQQTGVRWLWELHCQQAG
GILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYR-QGLGPTVIVCPTTVMHQWVKEFHT
WWPPFRVAVLHETGSCTHRKEKLIRDIAHCHGILITSYSYIRLMQDDISRHDWHYVILDE
GHKIRNPNAAVTLACK-----QFRTPHRI---IL--SGSPMQNNLRELWSLFDFIFPGKL
GTLPVFMEQFSVPITMGGYANASPVQVKTAYKCACVLRDTINPYLLRRMKSDVKMSLSLP
DKNEQV--LFCRLTDEQHKVYQ--NFIDSKEVYGILNGDMQVFSGLVALRKICNHP----
--------------------

ENSGT00590000083118_2_Linker_0_1 (921, 962)

GYWKRSGKMIVVESLLKIWHKQGQRVLLFSQSRQMLDILE
V

PF00271 // ENSGT00590000083118_2_Domain_1 (962, 1040)

FLRAQKYSYLKMDGTTTVASRQPLITRYNEDTSIFVFLLTTRVGGIGVNLTGANRVIIY
DPDWNPSTDTQARERAWRIGQKKQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVLKDPKQ
RRFFKSNDLYELFTLTSPDASQSTETSAIF----------------------------AG
TGSDVQTPKRRLKRQLEPAVGTD--HNV---------PMSRKLTASSTSANGAT-SS---
---EEKSAAAGADVKAVASDQ--GDPLK-EVPEPPRGLTSS-DSLGEDT----GAVAG--
-RDESPVVSGNGECSESPRISRMSRTSGEESV-GEKQGLPDKRES-CQAQTEPLWERDQM
ENNSCKHKAKTKH-RAAEEGTLEKHRRPKQEPKSSKHRRDAKFEGTRIPHLVKRRQYRKQ
DGENEHEPKERGHDDYVLEKLFRKS-VGVHSVMKHDAIMDGASPDYVL---VEAEANRVA
QDALRALRHSRQQCLGATSGAPTWTGHRGSSGAPAGIK--SRFGQKRNSSFSVQRPSSAS
PKEKAQDGVMKKD---GKDTVSEHFSGKVEDAESSSGALTSSSLLAKMRARNHLILPERL
ESEPVPPHEP--PAPLPSSTEHDDLLVEMRNFIAFQARVDGQASTREILQEFESKLSASQ
SCVFRELLRNLCTFHRTSNGEGIWKLKPEYC

---------------------------------MPNERIPYSSQTQEQDCL-----QSQH
VNNNEEMAVKQEID-G--D-VEVEECLYSRS---PEEGPSTSAEGCASAAPRRGQALLHI
DRHQIQAVEPSAQAPELLGLGVDVYDQDVLEQCVLQQVDNAIHEASRVAQLADAEKEYRS
VVDDLTSCMSSLRQINKIIEQLSPQAAINRDINRKLDSVKRQKYNKEQQLKKITAKQKRL
QAILGGTEVK--IELDHASLEE-EDAEAG----PSCLGSMLMPVQETAWEELIRTGQMTP
FGTQIPQKQEKKPRKIMLNEESGFEKYLADQA--KLSFERKKQQAYNKRTARKAPTSVTP
ELNPTE----NDNKPNKKTKVLSKTDKRLKKHIKKLQKRAL--QFQGKVGLPRGKKPWES
DVRPKA-EGDSESEESEYLPTEEE-----DDDEADWAGADLSRDGTDYELRPVLKGQKRQ
KKVS---VQEIDDDFFPSSGEESEA--TGGGGGGGGAGRKVARCRDDGDEDYYKQRLRRW
NKLRLQDKE-KRLKLEDDSEESDAEFDEGFKVPGFLFKKLFKYQQTGVRW

PF00176 // ENSGT00590000083118_2_Domain_0 (591, 898)

LWELHCQQAG
GILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRFEGLGPTVIVCPTTVMHQWVKEFHM
WWPPFRVAILHETGSCTHKKENLIRDIAHCHGILITSYSYIRLMQDDISRYDWHYVILDE
GHKIRNPNAAVTLACK-----QFRTPHRI---IL--SGSPMQNNLRELWSLFDFVFPGKL
GTLPVFMEQFSVPITMGGYSNASPVQVKTAYKCACVLRDTINPYLLRRMKSDVKMSLSLP
DKNEQV--LFCRLTDEQLKVYQ--NFVDSKEVYRILNGDMQIFSGLIALRKICNHPD

ENSGT00590000083118_2_Linker_0_1 (898, 935)

LFS
GGTKNLKGLPEDELEEEDQFGYWKRSGKMIVVES

PF00271 // ENSGT00590000083118_2_Domain_1 (935, 1040)

LLKIWHKQGQRVLLFSQSRQMLHILE
VFLRAQKYSYLKMDGTTTIASRQPLITRYNEDKSIFVFLLTTRVGGLGVNLTGANRVIIY
DPDWNPSTDTQARERAWRIGQKRQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVLKDPKQ
RRFFKSNDLYELFTLTSPDASQSTETSAIF----------------------------AG
TGSDVQTPKRHLKRKIQTAFGTD--HDV---------PKCKKFPDSNTSANDAT-SS---
---EKESEAVGAKVIAVTSNQ--GDLFK-GDPHMSSTVTSS-NRLGEET----DMVST--
-PEQSLVISGNEECSHSSGIGSMSRRSGEESM-DEKQGLSDERES-CQGQIEPLWENEQM
ENNFYKHKSKTKHQCVAAAETLEKHVRPKQKPRNSKHHRDARFEGTRIPHLVKKRQYQKQ
DEENRSEAKEQSNDDYVLEKLFKKS-VGVHSVMKHDAIMDGASPDYVL---VEAEANRVA
QDALKALRLSRQRCLGAVSGVPTWTGHRASSGAPAGLK--SRFGQKRNSKFSVQHPSSVS
PAEKCQDGIMKKE---GKGNVPEHFSGRTEDAESSSGALTSSSLLAKMRARNHLILPERL
ESESGHLQEA--SAPM-LTTEHDDLLVEIRNFIAFQAHVDGQASTREILQEFESKLSASQ
SCVFRELLRNLCTFHRTSGGEGIWKLKPEYC

---------------------------------MSNEGVPHSHETQGLDCL-----PSEC
IQSDAEMAIQEEDTEG--MEVEGEALLPPRV---PGDGPSTSAGDGMSTAARRGPALLHI
DRHQIQAVEPSAQALELQGLGVDVYDQAVLEQGVLQQVDSAIHKASCVAQLADAEKEYGS
VLDDLAACTTSLRQINKIIEQLSPQAATNKDVSRKLDSVKRQKYNKEQQLKKITAKQKRL
QAILGGAEAR--VELDHARLGA-EDAEPG----PSSLGSMLMPAQEAAWEELVRTGQMTP
FGTRIPQKQERKPRRLMLDEASGFEKYLAEQA--KLSLERKKR-AGGTRAARKAPAAVPA
TLSPAP----GGSEPGSRSRALSRADKRLKQHMKKLQRRAR--QFQGGLGLLRRGRPSEP
RAGPGA-AGDSEAEGSGDCPTDGEGPG-------AVAGADLSGDGPDYELKPLPQGRSRR
QRAP---AQEVDEDFFPSSEEDEEDG--GAAAAAAGNRRKAARCRDDGDEDSYRQRLRRW
NRLRLRDRG-ERGEREADSEESDAEFDEGFRVPGFLFRKLFK

PF00176 // ENSGT00590000083118_2_Domain_0 (583, 897)

YQQTGVRWLWELHCQQAG
GILGDEMGLGKTIQIIAFLASLSYSKIRTRGSNYRFEGLGPALIVCPTTVMHQWVKEFHT
WWPPFRVAILHETGSYTHKKEKLIREIAHCHGILITSYSYIRLMQDDISRYDWHYVILDE
GHK-RNPNAAVTLACKQ---QQFRTPHRL---IL--SGSPMQNNLRELWSLFDFIFPGKL
GTLPVFMEQFSVPITMGGYSNASPVQVKTAYKCACVLRDTINPYLLRRMKSDVKMSLSLP
DKNEQV--LFCRLTDEQHKVYQ--NFIDSKEVYAILNGEMQIFSGLVALRKICNHP

ENSGT00590000083118_2_Linker_0_1 (897, 962)

DLFS
GGPKNLRGLPEEELE-EDQFGYWKRSGKMIVVESLLKIWHKQGQRVLLFSQSRQMLHILE
V

PF00271 // ENSGT00590000083118_2_Domain_1 (962, 1040)

FLRAQKYTYLKMDGTTTIASRQPLITRYNEDTSIFVFLLTTRVGGLGVNLTGANRVIIY
DPDWNPSTDTQARERAWRIGQKKQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVLKDPKQ
RRFFKSNDLYELFTLTSPDASQSTETSAIF----------------------------AG
TGSDVQTPRRHLKRKSQPALGTD--RGL---------PEGRALAESPASANDAP-VP---
---AEKPKAAGVEVNAGASEE--GGPLQ-GDPPTRGSATPG-DGLGEEP----HATSR--
-PEDSQAGGGSGTCPDAAGRGQAPGLCSEEST-DTRPGLSSPREG-CRAEAGPLWESEQT
ENSSLKHKAKTKHQNVAREGSPGKCATPKQQPRSSRPRRDAKFEGTRISHLVKKRRYRKQ
DNEDAREAGARSTDDYVLEKLFKKS-VGVHSVMKHDAIMDGASPDYVL---VEAEANRVA
QDALRALRLSRQRCLGATSGVPTWTGHRGASGAPAGGR--SRFGQKRNSHLSAQC-----
PTEKRQDSVAGQE---GKDRGPGHFSGHAEEAESSSGAPSSSSLLAKMRARNHLIVPERL
ESEDGHLLGAAGPAPAPSATEHDELLVEVRNFIAFQARVDGQASTQEILREFESRLSASQ
SCVFRELLRNLCTFRRAAGGEGIWKLKPEYC

---------------------------------MTAEKSPQQNIMDGQDQGD----TGSN
PAGSGEMEVEQDDSPLS-NGFHMGEFQKELS----FENKTLELSSDGSEALGK-GPLLFI
NRQQIQSVAHDARADELRGLEIDVYDQDILEQGVLQQVDNAINEANK-VQIADAEKSYQS
VIDDIRSCTKSLKQIDTIIEQLTPQSATCKPINRKLDSVKRQKYNKEQQLKKLRSKQKYL
QIILGRKISD---EIEDAVFE--NDGDPG----PSCLGSMLMPSEETEWENLIKTGQMTP
FGTKLQ-GRESRPRRIMLNDTSDFEKYLTDQA--KLSCEKKKTS-VKKWTKKEAL-SEKS
Q--TKA----SIKGKGSTSKSQSKTDHHLNKRLKTLQNHALQMQVKSRL--SKTKE----
---LERGEQQEDSDGSVYMPDEELSNLEDEEEYYEDDT-------NDLITKPRLWRQKK-
--SS-RQESQDEPVWVDSSSTSDEET------EGMIKKRGIKRYRDDGNEDYFKQRLRKW
HKQERKQQQ----MTGEDSEESDVEFPEGFKVPGFLFKKLFK

PF00176 // ENSGT00590000083118_2_Domain_0 (583, 897)

YQQTGVRWLWELHCQQVG
GILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRFTGLGPSLIVCPTTVMHQWVKEFHN
WWPPFRVAVLHETGSYIKKKVKLIREIAACNGILITSYSYVRLLQESIHRYNWHYVILDE
GHKIRNPNAAVTLACK-----QFSTPHRI---IL--SGSPIQNNLKELWSLFDFVFPGKL
GTLPVFMEQFSVPITMGGYCNASPVQVKTAYKCACILRDTINPYLLRRMKANVKMSLSLP
DKNEQV--LFCRLTDEQHEVYK--RFIDSKEVYQILNGEMQIFSGLTALRKICNHP

ENSGT00590000083118_2_Linker_0_1 (897, 962)

DIFS
GGPKILKGVPDEELNEEDHFGFWKRSGKMIVVESLLKIWYKQGHRVLLFTQSRQMLHIIE
A

PF00271 // ENSGT00590000083118_2_Domain_1 (962, 1040)

FLKQRSYSYVKMDGTTTVASRQPLISRFNEDTSIFIFLLTTRVGGLGVNLTGADRVIIY
DPDWNPSTDTQARERAWRIGQTKEVTVYRLLTAGTIEEKIYHRQIFKQFLTNRILKDPKQ
RRFFKSNDLYELFSLSNPDGTQETETSAIF----------------------------AG
TGSDVPKPKKQKLHKAAKHSYVS---KEYCHFAEPTSSTSTALPNSLSARQNVNSHP---
-----------IERDSVESGT--SNLPK-DYAQSTASGGTDSFSVGEES--EKGSVSRVK
GATKNMGILNSGECSINCER---------------QHTLIYEE----KRHRKEQGANEQL
DNNYSKHTSKRKHHETT--------------SRKSKRSRGAKFEGERIPHLVKQKRYRKE
ENEET--KDLEKNDDYVLEKLFKKS--GIHSVMKHDVIMEASSPDYVL---LETEANRVA
QDALRALRMSRQRYQGVTSNIPGSGGLPG------LTK--KRFGQKRKLNLAVPSPTSPS
TAKKFKGTESEREE--NKNISNSHFTGRTEAGESSSSTLDSSFLLAKMRERNHLPHRTDG
QTDS-RVQQ--AVAALPVAREHEELLMDIQNFVAFRVRVPGQASTQEILQEYESKLSVEQ
SCIFRELLRNICNFHRHSSGEGIWKLKPEFS

---------------------------------MPYEDIPTSPQPQEQDCS-----PSQH
AGASEDLPVGQESG-G--D-SEAGACLSPSL---EEYGPATSAEACVLAATRRGPGLLHI
DRHQIPAVERSAQAPELQGLGVDVYDQAVLEQGVLQQVDSAMLEASRAAQSADAEKEYQS
VLDDLVSCTTSLKQINKIIEQLGPQAATNRDVNRKLDSVKRQKYNKEQQLKKITAKQKRL
QAILGGAGVQ--VERNHASLEE--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------EDARW
NKLRLQDKE-KRLKLEDDSEESDAEFDEGFKVPGFLFKKLFKYQQTGVRW

PF00176 // ENSGT00590000083118_2_Domain_0 (591, 898)

LWELHCQQAG
GILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRFEGLGPTIIVCPTTVMHQWVKEFHT
WWPPFRVAILHETGSYAHKKERLIRDIVHCHGVLITSYSYIRLMQDDISRHDWHYVILDE
GHKIRNPNAAVTLACK-----QFRTPHRI---IL--SGSPMQNNLRELWSLFDFIFPGKL
GTLPVFMEQFSVPITMGGYSNASPVQVKTAYKCACVLRDTINPYLLRRMKSDVKMSLSLP
DKNEQV--LFCRLTDEQHKVYQ--NFIDSKEVYRILNGDNQIFSGLVALRKICNHPD

ENSGT00590000083118_2_Linker_0_1 (898, 935)

LFS
GGPKNLSGLPEDELE-EDQFGYWKRSGKMIVVES

PF00271 // ENSGT00590000083118_2_Domain_1 (935, 1040)

LLKIWHKQGQRVLLFSQSRQMLHILE
VFLRAHKYSYLKMDGTTTIASRQPLITKYNEDTSIFVFLLTTRVGGIGVNLTGANRVIIY
DPDWNPSTDTQARERAWRIGQKKQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVLKDPKQ
RRFFKSNDLYELFTLSSPDASQSTETSAIF----------------------------AG
TGSDVQTHKCHLKKKTPPALGID--------------PKCKKLPFSGTSANGAI-LT---
---E-ESKATGPSG-SAASRE--GGPLK-GDCHPSSSRADS-AAFGEER----GAEPE--
-LEEVSEMSGDGQCADSAAVEQTSGPSGEAGT-SEKRGPSYKGEC-CQVQTEPVCLSEQT
EGHFCKHKSKRKH-DVAKEETPEKRPQPKQKAKTSKHCRDAKFEGTRVPYLVKKRRYRQE
SSEQENKAKEQSSDDYVLEKLFKKS-VGVHSVVKHDAIMDGTNPDYVL---VEAEATRVA
QDALKALKFSRQQCLGAASGVPTWTGHRGVSGAPAGIK--NRFGKKRNSSLPVHRP-S-S
LTEKHQDH-VKQE---GRVPAPQHFSGKEDGAAPLSGAPSSSSLLARMRARNHLILPERL
ESDSGHLAEA--AALPPSGTEHDDLLVEMRNFIAFQAQVDGQASTQEILQEFESKLSVAQ
SCVFRELLRNLCNFHRTPGGEGIWKLKPEYC

---------------------------------MPNEGIPHSSQTQEQDCL-----QSQP
VSNNEEMAIKQESS-G--D-GEMEEYLRSHS---VGDGLFTSAEGCASAAPRRAPALLHI
DRHQIQAVEPSAQALELQGLGVDVYDQDVLEQGVLQQVDNAIHEASCASQLADAEKEYRL
VLDDLMSCTISLRQINKIIEQLSPQAATSRDINRKLDSVKRQKYNKEQQLKKITAKQKRL
QAILGGAEVK--VELDHASLEE-EDAEPG----PSSLGSMLMPVQETAWEELIRTGQMTP
FGTQIPQKQEKKPRKIMLNEASGFEKYLADQA--KLSFERKKQ-ACNKRAARKAPAPVIS
-PAPMQ----NENKPNKKTKLLLKKEERLKKHIKKLQKRAL--QFQGKVGLPKTRRPWES
DMRPQA-EGDSEGEESEYFPTEEE-----EDDEVEGVEADLSGDGTDYELKSLPKGRKWQ
KKVP---VQEIDDDLFLSSGEEAETSV---GGGGGGGGRKVGRYRDDGDEDYYKWRLRRW
NKLRLQDKK-KRLKLEDDSEESDAEFDEGFKVPGFLFKKLFKYQQTGVRW

PF00176 // ENSGT00590000083118_2_Domain_0 (591, 898)

LWELHCQQAG
GILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRFEGLGPTVIVCPTTVMHQWVKEFHT
WWPPFRVAILHETGSYTHKKEKLIRDVAHCHGILITSYSYIRLMQDDISRYDWHYVILDE
GHKIRNPNAAVTLACK-----QFRTPHRI---IL--SGSPMQNNLRELWSLFDFIFPGKL
GTLPVFLEQFSVPITMGGYSNASPVQVKTAYKCACVLRDTINPYLLRRMKSDVKMSLSLP
DKNEQV--LFCRLTDEQHKVYQ--NFIDSKEVYRILNGEMQIFSGLIALRKICNHPD

ENSGT00590000083118_2_Linker_0_1 (898, 935)

LFS
GGPKNLKGLPDDELE-EDQFGYWKRSGKMIVVES

PF00271 // ENSGT00590000083118_2_Domain_1 (935, 1040)

LLKIWHKQGQRVLLFSQSRQMLDILE
VFLRAQKYTYLKMDGTTTIASRQPLITRYNEDKSIFVFLLTTRVGGLGVNLTGANRVVIY
DPDWNPSTDTQARERAWRIGQKKQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVLKDPKQ
RRFFKSNDLYELFTLTSPDASQSTETSAIF----------------------------AG
TGSDVQTPKCHLKRKIQPAFGAE--HDI---------PKHKKFPASNIPVNDAT-SS---
---EEKPKAKGGEINAVTSSQ--SDPLK-DDPHTSSNVTSS-DRLGEET----NAVFG--
-PEESSVISGNGECSNS-RTGKTSRLSGDESI-DEKLGLSYKREIPSQAQTESFWENKQM
ENKFYKHKSKTKHHNAAEEKTLEKHLRPKQKSKNPKHCRDAKFEGTRIPYLVKKRRYQKQ
DTENKSEAKEQSNDDYVLEKLFKKS-VGVHSVMKHDAIMDGASPDFVL---VEAEANRVA
QDALKALRLSRQRCLGAVSGVPTWTGHRGISGAPAGTK--SRFGKKRNSNFSVQHPSSKS
PAGKCQDGIMKKE---VKDNVPGHFSGRAEDAESSSGALASSSLLAKMRARNHLILPERL
ESESGHLQEA--SAPL-STTEHDDLLVEMRNFIAFQAHTDGQASTREILQEFESKLSASQ
SCVFRELLRNLCTFHRTSGGEGIWKLKPEYC

---------------------------------MPNEGISHSSQTQEQDYL-----QSQP
ISNNEEMAIKQESG-G--D-GEVEEYLPFSS---VGDGLSTSAEGCASAALRRGPALLHI
NRRQIQAVEPSAQALELQGLGVDVYDQDVLEQGVLRQVDNAIHEASCASQLADVEKEYRS
VLDDLTSCTTSLRQINKIIEQLSPQAATSRDINRKLDSVKRQKYNKEQQLKKITAKQKHL
QAILGGAEVK--IELDHASLE--EDAEPG----PSCLGSMLMPVQETAWEELIRTGQMTP
FGTQIPQKQEKKPRKIMLNEASGFEKYLADQA--KLSFERKKQATCNKRPARKAPASVTP
-PAPAQ----SKSKPNKKAKVLSKKEERLKKHIKKLQKRAL--QFQGKVGLPKARRPWES
DMRPEA-EGDSEGEESEYFPTEEEE--EEEDDEVEGVEADLSGDCTDYELKPLPKGRKQQ
KKVP---VQEIDDDFFPSSGEEAEASPIGEG---GGGGRKVGRYQDDGDEDYYKQRLRRW
NKLRLQDKE-KRLKLEDDSEESDAEFDEGFKVPGFLFKKLFKYQQTGVRW

PF00176 // ENSGT00590000083118_2_Domain_0 (591, 898)

LWELHCQQAG
GILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRFEGLGPTVIVCPTTVMHQWVKEFHT
WWPPFRVAILHETGSYTHKKEKLIRDVAHCHGILITSYSYIRLMQDDISRYDWHYVILDE
GHKIRNPNAAVTLACK-----QFRTPHRI---IL--SGSPMQNNLRELWSLFDFIFPGKL
GTLPVFMEQFSVPITMGGYSNASPVQVKTAYKCACVLRDTINPYLLRRMKSDVKMSLSLP
DKNEQV--LFCRLTDEQHKVYQ--NFVDSKEVYRILNGEMQIFSGLIALRKICNHPD

ENSGT00590000083118_2_Linker_0_1 (898, 935)

LFS
GGPKNLKGLPDDELE-EDQFGYWKRSGKMIVVES

PF00271 // ENSGT00590000083118_2_Domain_1 (935, 1040)

LLKIWHKQGQRVLLFSQSRQMLDILE
VFLRAQKYTYLKMDGTTTIASRQPLITRYNEDTSIFVFLLTTRVGGLGVNLTGANRVVIY
DPDWNPSTDTQARERAWRIGQKKQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVLKDPKQ
RRFFKSNDLYELFTLTSPDASQSTETSAIF----------------------------AG
TGSDVQTPKCHLKRKIQPAFGTD--HDV---------LKRKKFPASNISINDAT-SS---
---EDKSEAKGAEVNVVPSNQ--SDPLK-DDPHMSSNVASN-DRLGEET----NTVSG--
-PEESSVISGNGECSNSSGTGKTSRPSGDESI-EEKLGLSYKRERPNQVQTESFWENKQM
ENNFS----------VAEEETLEKHLRPKQKPKNPKQCRDAKFEGTRIPHLVKKRRYRKQ
GSENKSEAKEQSNDDYVLEKLFKKS-VGVHSVMKHDAIMDGASPDYVL---VEAEANRVA
QDALKALRLSRQRCLGAVSGVPTWTGHRGISGAPAGTK--SRFGKKRNSNFSVQHTSSTS
PTEKCQDGIMKKE---GKDNVPEHFSGRAEDADSSSRALASSSLLAKMRARNHLILPERL
ESESRHLQEA--SALL-PTTEHDDLLVEMRNFIAFQAHTDGQASTREILQEFESKLSASQ
SCVFRELLRNLCTFHRTSGGEGIWKLKPEYC

---------------------------------MASEETPSSTQNQEQDSL-----QSWH
ASANEDVPVED---------SEVREYLPCTP---CDYGPSTTTETCVLAARRRGPTLLHI
DRNQIPVVEPSAQALELQGLGVDVYDQAVLEQGVLQQVDSAMHEASRVAQLADAEKEYQS
VLDDLMSCTTSLRQINKIIEQLSPQAATNRDINRKLESVKRQKYNKEQQLKKITAKQKRL
QAILGGAEVQ--VELDHASLEE-EDAEPG----PSCLGSMLMPAQEMAWEELIRTGQMTP
FGTPAPQKQEKKPRKIMLNEVSGFEKYLADQA--QLSFERKKQ-AASKRAASKVL--VTS
KSKPGQ----NEAKPNQRSRVLSQTDKRLKKHIRRLQKRAL--QFQGKTGMPRR-KPQEP
EMKPEA-EGDSEGEESGSFPTEGEEEEQEEE---EERIANLSSDDTNYELRPLCKGQKRQ
-KVP---VQEVDDDFFPSSGEEDEAVE------GGRGGRKVVRCRDDGDEDYYKQRLRRW
NKLRLQDRE-ECLKLEDDSEESDADFDEGFKVPGFLFKKLFKYQQTGVRW

PF00176 // ENSGT00590000083118_2_Domain_0 (591, 898)

LWELHCQQAG
GILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRFEGLGPTVIVCPTTVMHQWVKEFHT
WWPPFRVAILHETGSYAYKKEKLIRDIVHCHGILITSYSYIRLMQDDISRHDWHYVILDE
GHKIRNPNAAVTLSCK-----QFRTPHRI---IL--SGSPMQNNLRELWSLFDFVFPGKL
GTLPVFMEQFSVPITMGGYSNASPVQVKTAYKCACVLRDTINPYLLRRMKSDVKMSLSLP
DKNEQV--LFCRLTDEQHKVYQ--NFIDSKEVYGILNGDNQIFSGLVALRKICNHPD

ENSGT00590000083118_2_Linker_0_1 (898, 935)

LFS
GGPKNLSGPPEDELE-EDQFGYWKRSGKMIVVES

PF00271 // ENSGT00590000083118_2_Domain_1 (935, 1040)

LLKIWHKQGQRVLLFSQSRQMLHILE
VFLRAHKYSYLKMDGTTTIASRQPLITRYNEDTSIFVFLLTTRVGGIGVNLTGANRVIIY
DPDWNPSTDTQARERAWRIGQKKQVTVYRLLMAGTIEEKIYHRQIFKQFLTNRVLKDPKQ
RRFFKSNDLYELFTLTSPDTSQSTETSAIF----------------------------AG
TGSDVQTPKRQLKRKTLPALETD--------------PKGKKFSHPNTSVNDSI-PT---
---EEKSKATGIAGN-ETYKE--SSLTK-GDCHTSRNITCG-VGLREDT----SAVSE--
-PEELPAVNGDEKCSNSPRVDKASRPSGEAST-SEKQGPSAKGDC-CQVQAKPLWVSRQV
ESHSCKHKTKRKH-GVAEEEIPEKHPLPKQNPK----NRDAKFEGTRIPHLVKKRGYHKQ
NTEQESEAKERSSDDYVLEKLFKKS-VGVHSVVKHDAIMDGTSPDYVL---VEAEASRVA
QDALKALRLSRQQCLGAASGIPTWTGHRGVSGAPARIR--NRFGQKRNSSFPMQRPSSTS
LTEKCQDT-VKKE---GKDPAPANLSGKEDTA-SLSRAPSSSSLLARMRARNHLILPERL
ESDSGHLPEA--ASLSPSTTDHDDLLVEMRNFIAFQAQVDGQASTREILQEFESKLSASQ
SCVFRELLRNLCTFHRTPGGEGIWKLKPEYC

---------------------------------MPNEGIPHSSQTQEQDYL-----QSQP
VSNNEEMAIKQESG-G--D-GEVEEYLPFSS---VGDGLSTSAEGCASAALRRGPALLHI
SRRQIQAVEPSAQALELQGLGVDVYDQDVLEQGMLRQVDNAIHEASRASQLADVEKEYRS
VLDDLTSCTTSLRQINKIIEQLSPQAATSRDINRKLDSVKRQKYNKEQQLKKITAKQKHL
QAILGGAEVK--IELDHASLE--EDAEPG----PSCLGSMLMPVQETAWEELIRTGQMTP
FGTKIPQKQEKKPRKIMLNEASGFEKYLADQA--KLSFERKKQATCNKRPARKAPASVTP
-PAPTQ----SKSKPNKKAKVLSKKEERLKKHIKKLQKRAL--QFQGKVGLPKARRPWEL
DMRPEA-EGDSEGEESEYFPTEEEE--EEEDDEVEGVQADLSGDSTDYELKPLPKGRKRQ
KKVP---VQEIDDDFFPSSGEEAEASPIGEG---GGGGRKVGRYQDDGDEDYYKQRLRRW
NKLRLQDKE-KRLKLEDDSEESDAEFDEGFKVPGFLFKKLFKYQQTGVRW

PF00176 // ENSGT00590000083118_2_Domain_0 (591, 898)

LWELHCQQAG
GILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRFEGLGPTVIVCPTTVMHQWVKEFHT
WWPPFRVAILHETGSYTHKKEKLIQDVAHCHGILITSYSYIRLMQDDISRYDWHYVILDE
GHKIRNPNAAVTLACK-----QFRTPHRI---IL--SGSPMQNNLRELWSLFDFIFPGKL
GTLPVFMEQFSVPITMGGYSNASPIQVKTAYKCACVLRDTINPYLLRRMKSDVKMSLSLP
DKNEQV--LFCRLTDEQHKVYQ--NFVDSKEVYRILNGEMQIFSGLIALRKICNHPD

ENSGT00590000083118_2_Linker_0_1 (898, 935)

LFS
GGPKNLKGLPDDELE-EDQFGYWKRSGKMIVVES

PF00271 // ENSGT00590000083118_2_Domain_1 (935, 1040)

LLKIWHKQGQRVLLFSQSRQMLDILE
VFLRAQKYTYLKMDGTTTIASRQPLITRYNEDTSIFVFLLTTRVGGLGVNLTGANRVVIY
DPDWNPSTDTQARERAWRIGQKKQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVLKDPKQ
RRFFKSNDLYELFTLTSPDASQSTETSAIF----------------------------AG
TGSDVQTLKCHLKRKIQPTFGTD--HDV---------LKRKKFPASNISINDAT-SS---
---EEKSEAKGAEVNVVLSNQ--SDPLK-DDPHMSSNVASN-DRLGEET----NAVSG--
-PEESSVISGNGECSNSSGTGKTSRPSGDESI-DEKLGLSYKRERPNQAQTESFWENKQI
ENNFCKHKSKTKHQSVAEEETLEKHLRPKQKPKNPKHCRDAKFEGTRIPHLVKKRRYRKQ
DNENQSEAKEQSNDDYVLEKLFKKS-VGVHSVMKHDAIMDGASPDYVL---VEAEANRVA
QDALKALRLSRQRCLGAVSGVPTWTGHRGISGAPAGTK--SRFGKKRNSNFSVQHPSSTS
PTEKCQDGIMKKE---GKDNVPEHFSGRAEDADSSSGALASSSLLAKMRARNHLILPERL
ESESRHLQEA--SALL-PTTEHDDLLVEMRNFIAFQAHTDGQASTREILQEFESKLSASQ
SCVFRELLRNLCTFHRTSGGEGIWKLKPEYC

---------------------------------MQNARIPHSNQTQEQDCL-----QSQY
VSDKQEMTIKQEND-A--N-VEVEESLPSCS---SANGPSTSAEGCLSEVARRGPAPLHI
DRHQIQTVEPSAQALELQGLGVDVYDQDVLEQGVLRQVDSAIHEASRAAQLADAEKEYRS
VLDDLTSCTTSLRQINKIIEQLSPQAATNRDINRKLDSVKRQKYNKEQQLKKITAKQKRL
QAILGGAEVQ--VELDHASLEE-EDIEPG----PSCLGSMLMPVQETAWEELIRTGQMTP
FGTQIPQKQEKKPRKLMLNEASGFEKYLADQA--KLSFERKKQ-ACNKRAARRTTSSVSS
ELSATL----NENKPNERSKVLSKTDKRLKKHIKKLQKRAL--HFQGKAGLPKGKKSLES
DARARA-EGSSEGDESEYLPTEEELE--------EAEGAELPGEGPDYELKPGLKHQKQQ
KKVM---VQEIEDDFFPSSGEEAEAAC-----G--GRGRKVVRCRDDGDEDYYKQRLRRW
NKLRLQDKE-KCLKLEDNSEESDAEFD-DFKMPGFLFKKLFK

PF00176 // ENSGT00590000083118_2_Domain_0 (583, 899)

YQQTGVRWLWELHCQQAG
GILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRFKGLGPTIIVCPTTVMHQWVKEFHT
WWPPFRVAILHETGSYTQKKEKLIRDIAHCHGILITSYSYIRLMQDDISRHDWHYVILDE
GHKIRNPNAAVTLACK-----QFRTPHRI---IL--SGSPMQNNLRELWSLFDFIFPGKL
GTLPVFMEQFSVPITMGGYSNASPVQVKTAYKCACVLRDTINPYLLRRMKSDVKMSLSLP
DKNEQV--LFCRLTEEQHRVYQ--NFIDSKEVYRILNGDMQIFSGLVALRKICNHPDL

ENSGT00590000083118_2_Linker_0_1 (899, 962)

FS
GGPKNPKDIPDGELE-EDQFGYWKRSGKMIVVESLLKIWHKQGQRVLLFSQSRQMLDILE
V

PF00271 // ENSGT00590000083118_2_Domain_1 (962, 1040)

FLRAQKYSYLKMDGTTAIASRQPLITRYNEDTSIFVFLLTTRVGGIGVNLTGANRVIIY
DPDWNPSTDTQARERAWRIGQKKQVTVYRLLTAGTIEEKIFHRQIFKQFLTNRVLKDPKQ
RRFFKSNDLYELFTLTSPDASQSTETSAIF----------------------------AG
TGSEVQAPKLHLKRKLPPACGTD--HNV---------PICKKFPDSNAATNEAT-SS---
---EEKSAATEAEVNAVTSDP--GDPLK-DAPQTPWSLPGS-DGPGEEA----STVSG--
-LEESSVISGRGDCSDSLTISRMDGLSSEESV-NEKQGLCDRRES-CQAQTEPLWENKQM
ESNFSKHKSKTKH-SAPE-EPLEQHRRPTWKPKSSKHRRDAKFEGTRIPHLVKKRRYQKQ
DSENENEAVEQSNDDYVLEKLFKKS-VGVHSVMKHDAIMDGANPDYVL---VEAEANRVA
QDALKALRLSRQRCLGASSGVPTWTGHRGISGAPAGVK--SRFGQKRNSNFSVQHPSSAS
SKEKCQDSVTRKD---GKDNASEHFSGKVEDAESSPGALSSSSLLAKMRARNHLILPERL
ESEIA-HPEA--SAPLSSTTEHDDLLVEMRNFVAFQARVDGQASTGEILQEFESKLSASQ
SCVFRELLRNLCTFHRTSSGEGIWKLKPEYC

---------------------------------MPSEGSPHCCQTQEQEPV-----RSPR
VGAEEGAPVEQEQEHG--GAAEAGECPPSPS---SACGPSTSAEDCTSAAVRRGPALLHI
DRHQIPAVEPSAQALELQGLGVDVYDQAVLEQGVLQQVDSALHEASRATQLADAEKEYHA
VLDDLTSCTTSLRQIDKIIEQLSPQAATNRDVNRKLDSVKRQKHNKEQQLKKITAKQKRL
QAVLGGAAVR--VELDHGS-LEQEDAEPG----PSCLGSMLMPAQETAWEELIRTGQMTP
FGTQVPQKTEKKPRKLMLNEASGFEKYLADQA--KLSFERRKQ-AASRRASRKAPASAQS
EPGAPA----RESEPKPRSKALSQADRRLQKHLRKLQRRALQLQFQGRPGQPRGKRPPEG
D-----SKGGSEGEEPRACPPEPLELDRAAEGAGEEVGASPSAEGADCEPRPVPRAQKRR
RKAL---VQGSDDDFSPSSGEEAEAEAAG---KGGGPSRKAVRCRDDGDGEHYKQRLRRW
NKLRLRDKE-ERLKLEDDSEESDAEFDEGFKVPGFLFRKLFKYQQTGVRW

PF00176 // ENSGT00590000083118_2_Domain_0 (591, 898)

LWELHCQQAG
GILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRFEGLGPTMIVCPTTVMHQWVKEFHT
WWPPFRVAILHETGSYAHRKEKLIRDIAHCHGILITSYSYVRLMQDDISRHDWHYVILDE
GHKIRNPNAAITLACK-----QFRTPHRI---IL--SGSPMQNNLRELWSLFDFVFPGKL
GTLPVFMEQFSVPITMGGYANASPVQVKTAYRCACVLRDTINPYLLRRMKSDVKMSLSLP
DKNEQV--LFCRLTDEQHKVYQ--NFIDSKEVYQILNGEMQIFSGLVALRKICNHPD

ENSGT00590000083118_2_Linker_0_1 (898, 936)

LFS
GGPKNLGGLPDEELE-EGQFGYWKRSGKMIVVESL

PF00271 // ENSGT00590000083118_2_Domain_1 (936, 1040)

LKIWHRQGQRVLLFSQSRQMLHILE
VFLRARGYSYLKMDGSTTIASRQPLITRYNQDTSIFVFLLTTRVGGLGVNLTGANRVIIY
DPDWNPSTDTQARERAWRIGQKRQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVLKDPKQ
RRFFKSNDLYELFTLTSPDSTQSTETSAIF----------------------------AG
TGSDVPTPRRHLKRRTPPAFGAD--QDA---------PKCGRFPDSATRTGAAT-PA---
---KAKPKAIGAEGSTVASGA--GG--L-GDAHPGGGVTAG-DGAGEET----GAGSG--
-PEAPLVTSGHGGSAASLRVSRAPGPPAEEDP-TTDQAPSAAGHS-GQVPAEPPWENGQA
GSRSWKHKSKTKHQAVAEEGALEQ----QRKPGSARHRRDAKFEGTRVPHLVKRRPYHRA
DAEPEPAAGARSGDDYVLEKLFKKS-VGVHSVVRHDAIMDGASPDYVL---VEAEANRVA
QDALKALRLSRQQCLGAASGIPTWTGRQGS-----RVR--GRFGQKRNSSLSGQRPPSS-
SAEKCQDG-------------VEHFSGRVQDPDSSPAALASSSLLARMRARNHLTLPERP
ES--RATAEA--PTPPPCATEHDELLVEMRNFIAFQARVDGQASTREILQEFESRLSTSQ
SCVFRELLRNLCSFHRTPSGEGVWRLKPEYC

---------------------------------MPNERIPHSSQTQEQDCS-----QNQD
ISESAEGTVKQEND-G--D-VELGESLPSCS---PANGPSTSAKGYPSELPRRGPALLHI
NRHQIQAVEPSAQALELQGLGVDVYDQDVLEQGVLQQVDSAIHEASRVAQLADAEKEYQS
VLDDLMSCTTSLRQINKIIEQLSPQADTNKDINRKLDSVKRQKYNKEQQLKKITAKQKRL
QAILGGAEVK--VELDHASLEE-EDAEAE----PSSLGSMLMPAQETAWEELVRTGQMTP
FGTQIPQKQERKPRKLMLNEASDFEKYLADQA--KLSFERKKQ-ACNKRATKKAPASVTS
ELSSTL----SENKPDKRGKVLSKTDERLKKHIKKLQKRAL--QFQGQVGLLKGKKPLEC
DVRPKA-EGDSEDEVSEYLPTEWEQG--------EAAGTDLSGEDTDCDRRRVLSRQKRQ
KKVT---VQEIDDDFFPSSGEEAEAAG----GG--GGGRKVVRCRDDGDEDYYKQRLRRW
NKLRLQDKE-KSLRLEDDSEESDAEFDEGFKVPGFLFKKLFK

PF00176 // ENSGT00590000083118_2_Domain_0 (583, 899)

YQQTGVRWLWELHCQQAG
GILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRFEGLGPTIIVCPTTVMHQWVKEFHT
WWPPFRVAVLHETGSFSHKKEKLIRDIAHCHGILITSYSHVRLMQDDISRHDW-YVILDE
GN-KRNPNAAITLACK-----QFRTPHRI---IL--SGSPMQNNLRELWSLFDFIFPGKL
GTLPVFMEQFSVPITMGGYSNASPVQVKTAYKCACVLRDTINPYLLRRMKSDVKMSLSLP
DKNEQV--LFCRLTDEQHKVYQ--NFIDSKEVYRILNGEMQIFSGLVALRKICNHPDL

ENSGT00590000083118_2_Linker_0_1 (899, 962)

FS
GGPKNLKGIPDEELE-EDQFGHWKRSGKMIVVESLLKIWHKQGQRVLLFSQSRQMLDIFE
V

PF00271 // ENSGT00590000083118_2_Domain_1 (962, 1040)

FLRAQKYSYLKMDGTTAIASRQPLITRYNEDTSIFVFLLTTRVGGLGVNLTGANRVIIY
DPDWNPSTDVQARERAWRIGQKKQVTVYRLLTARTIEEKIYHRQIFKQFLTNRVLKDPKQ
RRFFKSNDLYELFTLTSPDTSQSTETSAIF----------------------------AG
TGSDVQTPKRRLKRKLQPAFGTD--QNV---------PVGKKFPDSNTSANVAM-SS---
---EEKSTTRGPEVNAVTSNL--GDPLK-DAPQTSCSLTNS-ERLGEET----DAVSR--
-LQDSSVIHGNGEGSDSPRISKMYRMSGEESI-DEKEGLSDKRES-CRVQTEPLWENEQT
ENNFYKHKSKTKH-HVAEEKTLEKHLRPKQKLKSSKHRRDAKFEGTRIPHLVKKKQYRRQ
DNENESEPKERSHDDYVLEKLFRKS-VGVHSIMKHDAIMDGASPDYVL---VEAEANRVA
QDALKALRLSRQRCLGAASGVPTWTGHRGVAGTPAGRX--XXXXXXXXXXXXXXXXXXXX
XXXXXXDSTMKKD---GKDNVSEHFRGKVEDAEPSSGALTSSSLLAKMRARNHLILPERL
ESESGCLPEA--SAPPPSSMEHDDLLVEMRNFIAFQAQVDGQASTREILQEFESKLSASQ
SCVFRELLRNLCTFHRTSGGEGIWKLKPEYC

---------------------------------MPNEGIPHSSQSQEQDCL-----QSQP
VSNNEEMAIKQESG-G--D-GEMEEYLPFCS---VGDGLSTSAVGCASAAPRRGPALLHI
DRHQIQAVEPSAQALELQGLGVDVYDQDVLEQGVLQQVDNAIHEASRGSQLADVEKEYRS
VLDDLTSCTTSLRQINKIIEQLSPQAATSRDINRKLDSVKRQKYNKEQQLKKITAKQKHL
QAILGGAEVK--IELDHASLE--EDAEPG----PSSLGSMLMPVQETAWEELIRTGQMTP
FGTQIPQKQEKKPRKIMLNEASGFEKYLADQA--KLSFERKKQ-ACNKRAARKAPAPVTP
-PAPVQ----NKNKPNKKARVLSKKEERLKKHIKKLQKRAL--QFQGKVGLPKARRPWES
DMRPEA-EGDSEGEESEYFPTEEEE--EEEDEEVEGVEADLSGDGTDYELKPLPKGRKRQ
KKVP---VQEIDDDFFPSSGEEAEASSVGEG---GGGGRKVGRYRDDGDEDYYKQRLRRW
NKLRLQDKE-RRLKLEDDSEESDAEFDEGFKVPGFLFKKLFK

PF00176 // ENSGT00590000083118_2_Domain_0 (583, 897)

YQQTGVRWLWELHCQQAG
GILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRFEGLGPTVIVCPTTVMHQWVKEFHT
WWPPFRVAILHETGSYTHKKEKLIRDVAHCHGILITSYSYIRLMQDDISRYDWHYVILDE
GHKIRNPNAAVTLACK-----QFRTPHRI---IL--SGSPMQNNLRELWSLFDFIFPGKL
GTLPVFMEQFSVPITMGGYSNASSVQVKTAYKCACVLRDTINPYLLRRMKSDVKMSLSLP
DKNEQV--LFCRLTDEQHKVYQ--NFVDSKEVYRILNGEMQIFSGLIALRKICNHP

ENSGT00590000083118_2_Linker_0_1 (897, 962)

DLFS
GGPKNLKGLPDDELE-EDQFGYWKRSGKMIVVESLLKIWHKQGQRVLLFSQSRQMLDILE
V

PF00271 // ENSGT00590000083118_2_Domain_1 (962, 1040)

FLRAQKYTYLKMDGTTTIASRQPLITRYNEDTSIFVFLLTTRVGGLGVNLTGANRVVIY
DPDWNPSTDTQARERAWRIGQKKQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVLKDPKQ
RRFFKSNDLYELFTLTSPDASQSTETSAIF----------------------------AG
TGSDVQTPKCHLKRRIQPAFGAD--CDV---------PKRKKFPASNISVNDAT-SS---
---EEKSEAKGAEVNAVTSNQ--SGPLK-DDPYMSSNVTSS-DRLGEET----NPLSG--
-PEELSVISGNGECS---------RPSGDESI-DEKLGLSSKRERPSQAQTESFSENKQM
ENNFYKHKSKTKHHSVAEEETLEKYLRPKQKPKNSKHCRDAKFEGTRIPHLVKKRRYQKQ
DSENKSEAKEQSNDDYVLERLFKKS-VGVHSVMKHDAIMDGASPDYVL---VEAEANRVA
QDALKALKLSRQRCLGAASGVPTWTGHRGISGAPAGKK--SRFGKKRNSNFSVQHPSSTS
PTEKCQDGIMKKE---GKDNVPEHFSGRAEDADSSSGALASSSLLAKMRARNHLILPERL
ESESGHLQEA--SAVL-PTTEHDDLLVEMRNFIAFQAHTDGQASTREILQEFESKLSASQ
SCVFRELLRNLCTFHRTSGGEGIWKLKPEYC

---------------------------------MPNERISHSSQTKEQDCL-----QSQH
VSDDEEMTIKQEND-G--D-AEMEESLPSCS---STNGPYTSTEGCLSEILRRGPALLHI
NRHQIQAVEPSAQALELQGLGVDVYDQDVLEQGVLQQVDNAIHEVTHATQLADAEKEYRS
VLDDLTSCTTSLRQINKIIEQLSPQAATNRDINRKLDSVKRQKYNKEQQLKKITAKQKRL
QAILGGVEIK--VEIDHASLEE-DA-EAG----PSCLGSMLMPVQETAWEELIRTGQMTP
FGTQIPQKQEKKPRKLMLNEASGFEKYLADQE--KLSFERKKQ-ACNKRAARKTPALVNS
KLSPTL----NEKKPNRRSKVLSKTDKRLKKHVKKLQKRAL--QFQGKLRLPMGKKPLES
NVKPVA-EGDSEGEESEYIPTGEEEQE-------EAAGADLSGEGTESELGSVLKHCKWQ
KKGI---AQEVDDDFFSSSGEEDEAIT----GGRGRGSRKVVRCRDDGDEDYYKQRLRRW
NKLRLQDKE-KCLKLEDDSEESDAEFNEGFKIPGFLFKKLFK

PF00176 // ENSGT00590000083118_2_Domain_0 (583, 899)

YQQTGVRWLWELHCQQAG
GILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRFDGLGPTIIVCPTTVMHQWVKEFHM
WWPPFRVAILHESGSCTRKKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXX-----XXXXXXXX---XX--XXXPMQNNLRELWSLFDFI-PGKL
GTLPVFMEQFSVPITMGGYSNASPVQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXV--LFCRLTDEQHKVYQ--NFIDSKEVYRILNGEMQIFSGLIALRKICNHPDL

ENSGT00590000083118_2_Linker_0_1 (899, 962)

FS
GGPKNLKGIPDDELG-EDQFGYWKRSGKMIVVESLLKIWHKQGQRVLLFSQSRQMLDILE
I

PF00271 // ENSGT00590000083118_2_Domain_1 (962, 1040)

FLRAQKYSYLKMDGTTTIASRQPLITRYNEDTSIFVFLLTTRVGGLGVNLTGANRVIIY
DPDWNPSTDTQXRERAWRIGQKKQVTVYRLLTAGTIEEKIYHRQIFKQFLINRVLKDPKQ
RRFFKSNDLYELFTLTSPDASQNTETSAIF----------------------------AG
TGSDVQASKRHLKRKLQPAFGTD--HNV---------LISKKFPDSNVSANDAM-SS---
---EEKSTTVGAEVNVP-SDQ--GDPLR-DDPQTPSNLMSS-DRLVEKT----DAVSR--
-LECSSVMSGNGECSNSPRINKMYRTSGEESI-DEKQSFSDKRES-CQVQTEPLWENEQI
ENNFCKHKSKTKH-SVAEE-TQEKQLRPKQMSKNSKRCRDAKFEGTRIPHLVKKRQYQKQ
NSENESENKEQSNDDYVLEKLFKKS-VGVHSVMKHDAIMDGASPDYVL---VEAEANRVA
QDALKALRLSRQRCLGAVSGVPTWTGHRGVSGAP-GIK--SRFGQKRNSSFSVQPSSSAS
PKEKCQDGIMKKD---GKNHVSEQFSGKVEDAESLSRALTSSSLLAKMRARNHLILPERL
ESENVQLQEA--SAPPPSTTEHDDLLVEMRNFIAFQAHVDGQASTREILQEFESKLSASQ
SCVFRELLRNLCTFHRTSGGEGIWKLKPEYC

---------------------------------MPNERIPHSSQTQEPDCS-----QSQD
VSGSEEGTVKQEKD-G--D-MDLGQSLPSCS---SADGPSTSTEGCLLELPRRGPALLHI
DRHQIQAVEPSAQALELQGLGVDVYDQDVLEQGVLQQVDSAIHEASRVAQLAEAEKEYRS
VLDDLTSCTTSLRQIDRIIEQLGPQAATSKDVSRKLDSVKRQKYNKEQQLKKITAKQKRL
QAVLGGAEVK--VELGPGSLEE-EDAEAE----PSCLGSMLMPAQEAAWEELVRTGQMTP
FGTKIPQKQEKKPRKLMLNEASGFEKYLADQA--KLSFERKKQ-ACNRRAAKKASASATS
ELSSTL----SENKPDERGKVVSKTDKRLKKHIKKLQKRAL--QLQGQVGLLKGKKPWDC
DVSPQA-QGASEGEESEYLPTEEELE--------EAVGADLPGEGADWEQRLVLNRRKRQ
KKVT---VQEIDDDFFPSSGEEAEG-------T--GGGRKVVRCRDDGDEDYYKQRLRRW
NKLRLKDKE-ERSRREDGSEESDAELDEGFKMPGFLFRKLFK

PF00176 // ENSGT00590000083118_2_Domain_0 (583, 897)

YQQTGVRWLWELHCQQAG
GILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRFEGLGPTIIVCPTTVMHQWVKEFHT
WWPPFRVAVLHETGSFTHKKERLVRDIAHCHGILITSYSYIRLMQDDISRHDWHYVILDE
GHKIRNPNAAITLACK-----QFRTPHRI---IL--SGSPMQNNLRELWSLFDFIFPGKL
GTLPVFMEQFSVPITMGGYSNASPVQVKTAYKCACVLRDTINPYLLRRMKSDVKMSLSLP
DKNEQV--LFCRLTDEQHKVYQ--NFIDSKEVYRILNGEMQIFSGLVALRKICNHP

ENSGT00590000083118_2_Linker_0_1 (897, 962)

DLFS
GGPKSLKGAPDEELG-EDEFGYWKRSGKMIVVESLLKIWHKQGQRVLLFSQSRQMLDILE
V

PF00271 // ENSGT00590000083118_2_Domain_1 (962, 1040)

FLRAQKYSYLKMDGTTAIASRQPLIARYNEDTSVFVFLLTTRVGGLGVNLTGANRVIIY
DPDWNPSTDTQARERAWRIGQKKQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVLKDPKQ
RRFFKSNDLYELFTLSSPDTSQSTETSAIF----------------------------AG
TGSDVQTPRRHLKRRLQQACGTD--PNV---------PVGRQFPDGKTSANAAV-SS---
---EERPAAPGSEVRAGTSDQ--GIPLK-DAVQTPHSLTSS-ERLGEEA----DAVSR--
-PRESLVIHENGDSSGSPRIGRTCGTSGEESI-NEKESLSDKRER-CQVQREPLWENEQT
ENNCYKHKSKMKH-HVAEE-AREKHLRSNQKPESSKHRRDAKFEGTRIPHLVKKRQYRRR
ASENESEAKERSHDDYVLEKLFRKS-VGVHSVMKHDAIVDGASPDCVL---VEAEANRVA
QDALRALRLSRQRCLGAASGVPTWTGHRGLAGAPAGKK--SRFGQKRNSSFSLQRPSSTS
PKEKCQDSTVKKD---GKDHVLEHFSGKVEDAESSSGALTSSSLLAKMRARNHLILPERL
ESEIGRLPEA--AAPLPCSTEHDELLVEMRNFIAFQAQVDGQASTQEILQEFESKLSASQ
SCVFRELLRNLCTFHRTSAGEGIWKLKPEYC

---------------------------------MPNETTQHSSQTQEKDYL-----SSQF
FSNAEERAFDSENGGAV---DKMEESLTS---SPCNNRPSTSSVVGMFEVPRKGQSVLHI
NRQQIQSVEHSAQAVELKGLGVDVYDQDVLEQGVLRQVDNAINEANRAAQLAEAEKEYHS
VLDDLRSCTTSLKQINTIIEHLSPQAVNNKDVNRKLDSVKRQKDNKEKQLKKIKAKQRRL
QAIIGGTERD--TEVNLVDL---EDEEPG----PSSLGSMLMPVQETEWEELIRTGQMTP
FGTQIPQNQEKKPRKLMLNEASGFEKYLADQA--KLSFERKKVSLQKK--KKKIQASFDS
DMISTS----DKKEKSKTSGKQMKTDKRLNKHIKKLQRRAV--QFKSKVEFLKEKKALEP
KKPK-Y-EKGDESEESEYVPEDDDLLCSEEEEEEEL--ALCATNTGDHKLKVLSIHKKKQ
NKIP---TEEIDEDYLPSSEEEEEESM--------GRNGKIKRSRDDGDEDYYKQRLRRW
NKQRLEDKE-QRRKAEEESEESDAEFDEGFKVPGFLFKKLFK

PF00176 // ENSGT00590000083118_2_Domain_0 (583, 897)

YQQTGVRWLWELHCQQAG
GILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRFEGLGPTVIVCPTTVMHQWVREFHT
WWPPFRVAILHETGSYTNKKVKLIQEIARCHGILITSYSYIRLMQDNINNHDWHYVILDE
GHKIRNPNAAVTLACK-----QFRTPHRI---IL--SGSPMQNNLKELWSLFDFVFPGKL
GTLPVFMEQFSVPITMGGYSNASPVQVKTAYKCACVLRDTINPYLLRRMKSDVKMSLSLP
DKNEQV--LFCRLTDEQRKVYQ--NFIDSKEVYRILNGEMQVFSGLVALRKICNHP

ENSGT00590000083118_2_Linker_0_1 (897, 962)

DLFS
GGPKIIKGIPDDELEEADQFGYWKRSGKMIVVESLLKIWHKQGHRVLLFSQSRQMLHLLE
V

PF00271 // ENSGT00590000083118_2_Domain_1 (962, 1040)

FLRARDYSYLKMDGTTTIASRQPLITRYNEDTSIFVFLLTTRVGGIGVNLTGANRVIIY
DPDWNPSTDTQARERAWRIGQKKQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRILKDPKQ
RRFFKSNDLYELFTLSSPDESQSTETSAIF----------------------------AG
TGSDVQAPKHHLKRKFQSSSPVADKESV---------HQADVFPECSTSFDANI-SKAIS
GSVQEQDKAQETGVNLGTFNQ------------SSLSMESVEADLIEDKCVHTNIFSITD
EQSKNIMILGNGENLNSSCIAENFRIAGGEDL-DEKQDLLCKKGS-LKARLDPDLESKQT
KNQFSKHKAKTKHHLEE-GKDTLKHKGQKQNVKTSKHSKDARFEGTRIPHLVKQKRYQRH
DDEK--EENEQKNDDYVLEKLFKRS-GGVHSVMKHDAIMEASSPDYVL---VEAEANRVA
QDALKALKMSRQRCLGAVSGVPTWTGSNGLSGAPGGGK--SRFGQKRNPNLPASQPFSKS
TKEKCQDADLKKD---EKNATQTHFSGKIEGGESSSGALASSSLLAKMRTRNHLILPQRI
ENENVNLQQA--SASLLTATEHDDLLVEMRNFIAFQARIDGQASTQEILQEFESKLSTSQ
SCVFRELLRNLCTFHRGLNGEGVWKLKPEFC

---------------------------------MPNEGIPHSSQTQEQDYL-----QSQP
VSNNEEMAIKQESG-G--D-GEVEEYLPFSS---VGDGLSTSAEGCASAAPRRGPALLRI
NRHQIQAVEPSAQALELQGLGVDVYDQDVLEQGVLRQVDNAIHEASCTSQLADVEKEYRS
VLDDLMSCTTSLRQINKIIEQLSPQAATSRDINRKLDSVKRQKYNKEQQLKKITAKQKHL
QAILGGAEVK--IELDHASLE--EDAEPG----PSSLGSMLMPVQETAWEELIRTGQMTP
FGTQIPQKQEKKPRKIMLNEASGFEKYLADQA--KLSFERKKQATCNKRPARKAPASVTP
-PAPTQ----SKNKPNKKAKVLSKKEERLKKHIKKLQKRAL--QFQGKVGLPKARRPWES
DMRPEA-EGDSEGEESEYFPTEGEEE-EEEDDEVEGVEADLSGDGTDYELKPLPKGRKRQ
KKVP---VQEIDDDFFPSSGEEAEASLIGEG---GGGGRKVGRYRDDGDEDYYKQRLRRW
NKLRLQDKE-KRLKLEDDSEESDAEFDEGFKVPGFLFKKLFKYQQTGVRW

PF00176 // ENSGT00590000083118_2_Domain_0 (591, 898)

LWELHCQQAG
GILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRFEGLGPTVIVCPTTVMHQWVKEFHT
WWPPFRVAILHETGSYTHKKEKLIRDVAHCHGILITSYSYIRLMQDDISRYDWHYVILDE
GHKIRNPNAAVTLACK-----QFRTPHRI---IL--SGSPMQNNLRELWSLFDFIFPGKL
GTLPVFMEQFSVPITMGGYSNASPVQVKTAYKCACVLRDTINPYLLRRMKSDVKMSLSLP
DKNEQV--LFCRLTDEQHKVYQ--NFVDSKEVYRILNGEMQIFSGLIALRKICNHPD

ENSGT00590000083118_2_Linker_0_1 (898, 935)

LFS
GGPKNLKGLPDDELE-EDQFGYWKRSGKMIVVES

PF00271 // ENSGT00590000083118_2_Domain_1 (935, 1040)

LLKIWHKQGQRVLLFSQSRQMLDILE
VFLRAQKYTYLKMDGTTTIASRQPLITRYNEDTSIFVFLLTTRVGGLGVNLTGANRVVIY
DPDWNPSTDTQARERAWRIGQKKQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVLKDPKQ
RRFFKSNDLYELFTLTSPDASQSTETSAIF----------------------------AG
TGSDVQTPKCHLKRKIQPAFGAD--HDV---------PKRKKFPASNISINDAT-SS---
---EEKSEAKGAEVNVVPSNQ--SDPLK-DDPHMSSNIASN-DRLGEET----NAVSG--
-PEESSVISGNGECSNSSGTGKTSRPSGDESI-DEKLGLSYKRERPSQAQTESFWENKQM
ENNFYKHKSKTKHHSVAEEETLEKHLRPKQKPKNPKHCRDAKFEGTRIPHLVKKRRYQKQ
DSENKSEAKEQSNDDYVLEKLFKKS-VGVHSVMKHDAIMDGANPDYVL---VEAEANRVA
QDALKALRLSRQRCLGAVSGVPTWTGHRGISGAPAGTK--SRFGKKRNSNFSVQHSSSTS
PAEKCQDGIMKKE---GKDNVPEHFSGRAEDTDSSSGALASSSLLAKMRARNHLILPERL
ESESGHLQEA--SALL-PTTEHDDLLVEMRNFIAFQAHTDGQASTREILREFESKLSASQ
SCVFRELLRNLCTFHRTSGGEGIWKLKPEYC

---------------------------------MPTENSHLPDSIQEQDPIT--TLSSIC
PHNAEQKGTEQENGICN---SDLVNHFGVHN---SDSKPSTS-VAVPVEVPRRGQPLLHI
NRQQIQSVSHSAQAAELKGLGVDVYDQEVLEQGVIQQVDNAINEANRATKIADAEKEYQS
VLDDLRSCTTSLKQIDKIIEQLSPQATNNKDINRKLDSVKRQKYNKEQQLKKIKAKQKRL
QAVLGGTEIL-DK-VNEIEF-EDD-EEPG----PSSLGSMLMPIQETEWEELIRTGQMTP
FGTKIPQKPERKTRRLMLNEASDFEKYLADQA--KLSSERKKL-ALHKRVKKKAQAKNVQ
CVAPTS----ATKEKRGK--ALSKTDKRLKKHLKKLQKHAL--QVHSKAGIPKEKKNLET
T-KLKP-GQKDDSGESDYVPDE-HLEPEAVEEE-EEQASSHAENDSDYELRNLSGKGKYL
VKRDSK-DAGNDTDYFPSSEEE--EHT--------VGKRKVKRWRDDGDEDYYKQRLRKW
QRERLKDKE-RS-VAEELSDESDTEFEEGFKVPGFLFKKLFKYQQTGVRW

PF00176 // ENSGT00590000083118_2_Domain_0 (591, 898)

LWELHCQQAG
GILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRYQGLGPTVIVCPATVMHQWVKEFHT
WWPPFRVAILHETGSYTNKKVKLIREIASCHGILITSYSYIRLMQDNIHSYDWHYVILDE
GHKIRNPNAAVTLACK-----QFRTPHRI---IL--SGSPMQNNLKELWSLFDFVFPGKL
GTLPVFMEQFSVPITMGGYSNASPVQVKTAYKCACVLRDAINPYLLRRMKADVKMSLSLP
DKNEQV--LFCRLTDEQRQVYQ--NFIDSKEVYQILNGDMQVFSGLVALRKICNHPD

ENSGT00590000083118_2_Linker_0_1 (898, 935)

LFS
GGPKILKCVPDADLEEADQFGYWKRSGKMIVVES

PF00271 // ENSGT00590000083118_2_Domain_1 (935, 1040)

LLKIWHKQGHRVLFFTQSRQMLQILE
VFLRDRNYSYLRMDGTTTIASRQPLITRYNEDKSIFIFLLTTRVGGIGVNLTGADRVIIY
DPDWNPSTDTQARERAWRIGQKKQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVLKDPKQ
RRFFKSNDLYELFTLSSPDVSQGTETSAIF----------------------------AG
TGSDVQVPKHQLKRKLERPADD-DTLKGGLHLKKSSSPKYSKSSSSHLTRHRANS-S---
---EAIETSEEAKGNLETFDQ--NSYAK-DNAETATDINSV--NKSKQESLERADISLSQ
SLPGGAGSSENA-----KVTEEEHEVANENA--EGDFSLLCGAAG-SQEKQVDKTEDGQL
DNNHYKCTSKTKHRV-----DMLSHDSHKEKSK-KKHHKDAKFEGERIPHLVKQKRYKKE
DSEEK-ELDPKKNDDYVLEKLFKK-T-GVHSVMKHDAIMEASSADYVL---VEAEANRVA
QDALRALKVSRQRCLGAASGVPTWTGVSGLSGAPSGVK--SRFGQKRNPMLLSSHSTCVS
PMKKCKDADTMKKENVKKNSSNGHFDGKSETGESSSSILDSSSLLAKMRARNHLILPQRT
GNEGDDNLHQ-ASAPAPGSTEYDELLVDVRNFIAFQARVDGEASTQEILQEFESKLPAAQ
SCVFRELLRNLCSFHRNPNGEGVWRLKPEFR

---------------------------------MSNERIPHSSQTQDQAGV-----QSQY
VCESEGVTVKRENDGD----VELGESLPSCS---SASGPSTSAEGRLSEVPRRGPGLLHI
DRHQIQAVEPSAQALELQGLGVDVYDQDVLEQGVLQQVGSAIHEAGRAAQLADAEKEYWS
VLDDLTSCTTSLRQIDKIIEQLSPQAATNKDISRKLDSVKRQKHNKEQQLKKITAKQKRL
QAILGGAEVR--VEIEHASLEE-EEADAG----PSCLGSMLMPAQETAWEELVRTGQMTP
FGTQIPQKQEKKPRKLMLNEASGFEKYLADQA--KLSFERKKQ-ARNKRAARKAAAPVTS
ELSSTL----SE-KPNESSKVLSKTDKRLKKHIRKLQKRAR--QLQGQVGLPKGRRPLGS
DARLRA-EGDSEGEESEYLPTEEERE-----------EADLSGEGTDCDPGPVLSRGKRQ
KKVT---EQEIDDDFFPSSGEEADAAG------GGGGGRKVVRRRDDGDEDYYKQRLRRW
NKLRLQDKE-KRLRLEEDSEESEAEFDEGFKMPGFLFKKLFK

PF00176 // ENSGT00590000083118_2_Domain_0 (583, 893)

YQQTGVRWLWELHCQQAG
GILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRFEGLGPTIIVCPTTVMHQWVKEFHT
WWPPFRVAILHETGSFTHKKEKLIRDIAHCHGILITSYSYIRLMQDDISRHDWHYVILDE
GHKIRNPNAAITLACK-----QFRTPHRI---IL--SGSPMQNNLRELWSLFDFIFPGKL
GTLPVFMEQFSVPITMGGYSNASPVQVKTAYKCACVLRDTINPYLLRRMKSDVKMSLSLP
DKNEQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXX
XXXXXXXXXX-XXXX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
DPDWNPSTDTQARERAWRIGQTKQVTVYRLLTAGTIEEKIYHRXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-----XXXX-XXXXXXXXXXXXX----XX
XXXXXXXXXXXXXXXXXXXXXXX--XXX---------XXXXXXXXXXXXXXXXXXXX---
---XXXXXXXXXXXXXXXXXX--XXXXX-XXXXXXXXXXXX-XXXXXXX----XXXXX--
-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-X-XXXXXXXXXX--XXXXXXXXXXX-X
XXXXXXX--XXXXXXXXXXXXXXXX---XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-
X--X--XXXXXXXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXXX---XXXXXXXXX
--XXXXXXX----XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXDGTMKKD---GKNHVSEHFSGKMEDAESSSGALTSSSLLAKMRARNHMILPERL
ESEGVPLPEA--AALPPSSAEHDDLLVEMRNFIAFQAQVDGQASTREILQEFESKLSASQ
SCVFRELLRNLCTFHRTPGGEGIWKLKPEYC

---------------------------------MQNARISHSSQTQEQDCLLSKTEQSQC
VSDKQEMTIKQEDD-G--N-MEVEESLPSCS---SANGPSASAEGRSSEVPKRGPALLHI
DRHQIQTVEPSAQALELQGLGVDVYDQDVLEQGVLRQVDSAIHEASRAAQLADVEKEYRS
VLDDLTSCTTSLRQINKIIEQLSPQAATNRNVNRKLDSVKRQKYNKEQQLKKITAKQKRL
QAILGGVEVQ--VELDHASLEE-EDIEPG----PSCLGSMLMPIQETAWEELIRTGQMTP
FGTQIPQKSEKKPRKLMLNEASGFEKYLADQA--KLSFERKKQ-ACNKRAARKAIASVAS
ELSSTV----DENKTNERSKVLSKTDKRLKKHIKKLQKRAL--HFQGRVGLPKGKKTLES
DMRLKV-EGNSEGEESEYLPTEEELE--------EAEGVKLTGEDKDYELNPMLKRWKRQ
KKVM---VQENEDDFSPSSGEEAEAAC-----G--GRGRKVVRCRDDGDEDYYKQRLRKW
NKLRLQDKE-KCLKLEDDSEESDAEFD-DFKMPGFLFRKLFK

PF00176 // ENSGT00590000083118_2_Domain_0 (583, 899)

YQQTGVRWLWELHCQQAG
GILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRFKGLGPTIIVCPTTVMHQWVKEFHT
WWPPFRVAILHETGSYTQKKEKLIRDIAHCHGILITSYSYIRLMQDDISRHDWHYVILDE
GHKIRNPNAAVTLACK-----QFRTPHRI---IL--SGSPMQNNLRELWSLFDFIFPGKL
GTLPVFMEQFSVPITMGGYSNASPVQVKTAYKCACVLRDTINPYLLRRMKSDVKMSLSLP
DKNEQV--LFCRLTEEQHKVYQ--NFIDSKEVYRILNGDMQIFSGLVALRKICNHPDL

ENSGT00590000083118_2_Linker_0_1 (899, 962)

FS
GGPKNLKTIPDDD-E-EDQFGYWKRSGKMIVVESLLKIWHKQGQRVLLFSQSRQMLDILE
V

PF00271 // ENSGT00590000083118_2_Domain_1 (962, 1040)

FLRAQKYSYLKMDGTTAIASRQPLITRYNEDTSIFVFLLTTRVGGIGVNLTGANRVIIY
DPDWNPSTDTQARERAWRIGQKKQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVLKDPKQ
RRFFKSNDLYELFTLTSPGASQSTETSAIF----------------------------AG
TGSEVQTPKLHLKRKLPPAFGAD--HNI---------PICRKFPDSNASTNDTT-SS---
---EEKFTAKGAGVNTITSDQ--GDPLK-DAPQTPRNLTGS-GGPEEKT----KAVPI--
-LEELSVTSGRVDCSSSPRTSKMDGLSSEESI-HEKQGLSDRRES-CQAQTEPLQENKES
ENNFSKHKSKTKH-SVLEEETLEQLQRPKSKPKNTKHCRDARFEGTRIPHLVKKRRYQKQ
DSEIESETSEQSNDDYVLEKLFKKS-VGVHSVMRHDAIMDGADPDYVL---VEAEANRVA
QDALKALRLSRQQCLGASSGVPTWTGHRGISGAPAGIK--SRFGQKRNSKFSVQHPSSAS
SKEKCQDGVPRKD---GKDNASEHFSGKVEDAESSPGALPSSSLLAKMRARNHLILPQRL
ESENA-HQEA--PAPPPPTTEHDDLLVEMRNFIAFQARVDGQASTQEILQEFESKLSASQ
SCVFRQLLRNLCTFHRTSSGEGIWKLKPEYC

---------------------------------MQNAGIPHSSQAQEQDCL-----QSQC
VSDKQEMTIKREND-G--N-AEVEESLPSCS---SASGPSTSAEGCSSEVLRRGPALLHI
DRHQIQTVELSAQALELQGLGVDVYDQDVLEQGVLRQVDSAIHEASRAAQLADAEKEYRS
VLDDLTSCRTSLRQINKIIEQLSPQAATNRDVNRKLDSVKRQKYNKEQQLKKITAKQKRL
QAILGGAEVQ--VEIDHAGLEE-EDTEPG----PSCLGSMLMPVQEAAWEELIRTGQMTP
FGTQIPQKQEKKPRKLMLDEASGFEKYLADQA--KLSFERKKQ-ACNKRAARKTAASGTS
ELSATL----SENKPSERSKVLSKADKRLRKHIKKLQKRAL--HFQGKVGLPKGKKPLES
DVRPKA-EGTSESEESEYFPTEEEQE--------EAEGAELTGEGPDSVLKPVLKHRKRQ
KKVT---VQEMGDDFFPSSGEEAEATC-----G--GGGRKVVRCRDDGDEDYYKQRLRRW
NKLRLRDKE-KCLKLEGDSEESDAEFD-DFKIPGFLFKKLFKYQQTGVRW

PF00176 // ENSGT00590000083118_2_Domain_0 (591, 898)

LWELHCQQAG
GILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRFKGLGPTIIVCPTTVMHQWVKEFHT
WWPPFRVAILHETGSYTHKKEKLIRDIAHCHGILITSYSYIRLMQDDISRHDWHYVILDE
GHKIRNPNAAVTLACK-----QFRTPHRI---IL--SGSPMQNNLRELWSLFDFIFPGKL
GTLPVFMEQFSVPITMGGYSNASPVQVKTAYKCACVLRDTINPYLLRRMKSDVKMSLSLP
DKNEQV--LFCRLTEEQLKVYQ--NFIDSKEVYRILNGDMQIFSGLVALRKICNHPD

ENSGT00590000083118_2_Linker_0_1 (898, 935)

LFS
GGPKNLRGIPDEELE-EDQFGYWKRSGKMIVVES

PF00271 // ENSGT00590000083118_2_Domain_1 (935, 1040)

LLKIWHKQGQRVLLFSQSRQMLDILE
VFLRAQKYSYLKMDGTTAIASRQPLITRYNEDTSIFVFLLTTRVGGIGVNLTGANRVIIY
DPDWNPSTDTQARERAWRIGQKKQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVLKDPKQ
RRFFKSNDLYELFTLTSPDVSQSTETSAIF----------------------------AG
TGSDVQTPKRLLKRKLLPAFGTD--PNV---------SICKKCPDSNASANDAT-SS---
---EEKSTATGAEVNAVTSDQVTSDPLK-DAPRTPRDLTGG-DGPGEEA----SAVSR--
-PEESSVMSGHGECSDSPGISKMDGLSSEESI-HEKQGLSDKRES-CQAPTDPLRENKQT
ENNFYKHKSKTKH-SAPEEETLEHRRRLKQKPKNSKHRRDAKFEGTRIPHLVKKRRYQKQ
DSENENETSQQSNDDYVLEKLFKKS-VGVHSVMKHDAIIDGANPDYVL---VEAEANRVA
QDALKALRLSRQRCLGAVSGVPTWTGHRGVSGAPAGIK--SRFGQKRNSNFSLQHPSSTS
SKEKCQDGVTRKD---GKDNASEHFSGKVEDAESSPGALPSSSLLAKMRARNHLILPERL
ESDSA-HQEA--SAPPSATTEHDDLLVEMRNFIAFQARVDGQASTREILQEFECKLSASQ
SCVFRELLRNLCTFHRTSSGEGIWKLKPEYC

---------------------------------MPSEGSRHSCQTQEQEHS-----QSPP
VRADEDTTG--EQEHG--GAVEVGKQLASPP---SDCGPSTSAEGCTSAAMRRGPTLVHI
DRHQIPAVERNAQALELQGLGVDVYDQTVLEQGVLQQVDSALHEASRAAQLADAEKEYQS
VLDDLMSCMTSLRQINKIIEQLSPQAATNRDINRKLDSVKRQKYNKEQQLKKITVKQKRL
QAVLGRAEVR--VELEHAGGLEEEDAEPG----PSCLGIMLMPAQKTAWEELIRTGQMTP
FGTQVLQKTEKKPRKLMLNEASGFEKYLADQA--RLSFERKKQ-AANKRTSRKAAASVKP
ASNAQS----KENKPKQRSQILSKTDWRLKKHIRKLQKKAL--QFQGKVGLPRGKRSLGA
EARLQ-AMGNSESEEPRSFPMEG-----EEEGDGEEVGADLSGDGADCELRPELRGQKRQ
KKVP---AQENDDDFSPSSGEEAEA--TE---RGRGTGRKVVRCCDDGDEDYYKQRLRRW
TKLRLQNKE-KHLKLEDDSEESDAEFDEGFKVPGFLFKKLFKYQQTGVRW

PF00176 // ENSGT00590000083118_2_Domain_0 (591, 898)

LWELHCQQAG
GILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRFEGLGPTIIVCPTTVMHQWVKEFHT
WWPSFRVAILHETGSCTHRKENLIRDIAHCHGILITSYSYIRLMQDDFSRQNWHYVILDE
GHKIRNPNAAVTLACK-----QFRTPHRI---IL--SGSPMQNNLRELWSLFDFVFPGKL
GTLPVFMEQFSVPITMGGYANASPVQVKTAYKCACVLRDTINPYLLRRMKSDVKMSLSLP
DKNEQV--LFCRLTDEQHKVYQ--NFINSKEVYKILNGEMQLFSGIVALRKICNHPD

ENSGT00590000083118_2_Linker_0_1 (898, 935)

LFS
GGPKNLGGLPDDELE-EDQFGYWKRSGKMIVVES

PF00271 // ENSGT00590000083118_2_Domain_1 (935, 1040)

LLKIWHKQGQRVLLFSQSRQMLHILE
VFLRAQKYSYLKMDGTTTIASRQPLIARYNEDASIFVFLLTTRVGGIGVNLTGANRVIIY
DPDWNPSTDTQARERAWRIGQKRQVTVYRLLMAGTIEEKIYHRQIFKQFLTNRVLKDPKP
RRFFKSNDLYELFTLTSPNGSQSTETSAIFAGNTERPLISGNNLHTICALSISYAFPFTG
IGSDVPTPKRHLKRKILPAFGTD--RDV---------PKCKKFPDSNTLANVAT-SS---
---EHKSKATRAEGIMVTSSP--SNRLK-TDPHPGGRVTSS-DRVSEGT----SAASG--
-PEEPPVTSGNGDCSDCPRIGGALLLSGEENI-AAKQGPSDEGDS-GLVPAEPPRENEQV
GSHSYKHKSKRKHQGVAEEGTLEK----RQKHESTRHRRDAKFEGTRVPHLVKRRRYHRH
DLGPDSKARVHSGDDYVLEKLFKKS-VGVHSVVKHDAIMDGASPDYVL---VEAEANRVA
QDALKALRLSRQQCLGAASGVPTWTGHRGA-----RVK--SRFGQKRNSNLSVHRPSSS-
STEECQDGLVKRE---GKDHMSEHFSGKAEDTDSSSGALTSSSLLARMRARNHLILPERL
ESENGHVAEV--SAPPSCATEHDELLVDMRNFIAFQARVDGQASTRELLQEFEPKLSASQ
SCVFRELLRNLCTFHRTPGGEGVWRLRPEYC

---------------------------------MPNERISHSRQTEEQDCL-----QSQY
VSNNVEMTIKQENG-G--D-VEVEECLPSCS---PADGPSTSAERCASATPRRGPALLHI
DRHQIQAVEPSVQALELQGLGVDVYDQDVLEQGVLQQVDQAIHEASCVAQLADVEKEYRS
VLDDLTSCTTSLRQINKIIEQLSPQAATNRDINRKLDSVRRQKFNKEQQLKKITAKQKRL
QAILGGAEVK--VELDHASLEE-EDAEPG----PSCLGSMLMPVQEAAWEELIRTGQMTP
FGTQIPQKQEKKPRKIMLNEASDFEKYLADQA--KLSFERKKQA-YTKRAARKAPATVTS
ELTPTQ----NKNKPNKKTKVLSKTDKRLKKHIKKLQKKAL--QFQGKVGLPKAKKPWES
DMRPNA-EGDSGSEESEYFPSGED-----EEDDVEGTRADLSGDGTSCELRPVRKSCKRQ
KKVL---VQEIDDDFFSSSGEEAEA--------TGGGGQKVARCRDDGDEDYYKQRLRRW
NKLRLQDKE-KRLKLEDDSEESDAEFDEGFKVPGFLFRKLFKYQQTGVRW

PF00176 // ENSGT00590000083118_2_Domain_0 (591, 898)

LWELHCQQAG
GILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRFEGLGPTVIVCPTTVMHQWVKEFHT
WWPPFRVAILHETGSYTHKKEKLIRDIAHYHGILITSYSYIRLMQDDIGRYGWHYVILDE
GHKIRNPNAAVTLACK-----QFRTPHRI---IL--SGSPMQNNLRELWSLFDFVFPGKL
GTLPVFMEQFSVPITMGGYSNASPVQVKTAYKCACVLRDTINPYLLRRMKSDVKMSLSLP
DKNEQV--LFCRLTDEQHKVYQ--NFIDSKEVYRILNGEMQIFSGLVALRKICNHPD

ENSGT00590000083118_2_Linker_0_1 (898, 935)

LFS
GGPKNLKGLPDDELE-EDQFGYWKRSGKMIVVES

PF00271 // ENSGT00590000083118_2_Domain_1 (935, 1040)

LLKIWHKQGQRVLLFSQSRQMLHILE
VFLRARKYSYLKMDGTTTIASRQPLITRYNEDTSIFVFLLTTRVGGIGVNLTGANRVIIY
DPDWNPSTDTQARERAWRIGQKKQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVLKDPKQ
RRFFKSNDLYELFTLTSPDVSQSTETSAIF----------------------------AG
TGSDVQAPKRHFKKKSQPTFEID--PDV---------PKHKKFPGSDASANDAM-SS---
---EEKSKAIGAEINTITSNQ--SDPLK-DNPHTSSNVTNN-DRLGEET----NTGSR--
-PAESSVINGKGECSDSPRISKTSRPPGEESI-DEKQGLSYKREN-CQVQIEPLWENEQT
ENNFYKHKSKTKHHSVAEDETLEKHLRPKQKPKNSKHHRDAKFEGTRIPHLVKKRQYQKQ
DSENKSEVKEQSNDDYVLEKLFKKS-VGVHSVLKHDAIMDGANPDYVL---VEAEANRVA
QDALKALRLSRQRCLGAGSGVPTWTGHRGISGAPGGTK--SRFGKKRNSNFSS-----TS
PTDKCQDGIMKKE---GRDNVPGHFSGTAEDAESSSEVLPSSSLLAKMRARNHLILPQRL
ESDDGHLQEV--SASL-PTTEHDDLLVEIRNFIAFQAHVDGQASTREILQEFESKLSASQ
SCVFRELLRNLCTFHRTSGGEGIWKLKPEYC

---------------------------------MPNEGMPASSHTTEPDCP-----QSQS
VSNDEEAASRQGSD----GAVEEGESLPSCS---SDSGPSASAEGCVE-ALRRGPALLHI
DRHRIQAVEPSAQALELQGLGVDVYDQDVLEQGVLQQVDTAIHEASRAAQRADAEKEYRS
VLDDLTSCTISLRQINKIIEQLSPQAATNKDVSRKLDSVRRQKCNKEQQLKKITAKQKRL
QAILGGAEIK--AELDPASLEE-EDAEPG----PSCLGSMLMPVQEAAWEELIRTGQMTP
FGTRIPQKQEKKPRKIMLNEASGFEKYLADQA--KLSFERKKQ-ACNKRAARKAPALDPS
KVSPTR----NENRPNQRSRVLSRADKRLQKHMKKLQKRAL--QTQGKMGLPKRRKPLEP
EGRPKA-EGDSESEGSEYLPTEEEEEEE--EEEEAAAGADLSGDGTDYELKPMPKGRKRQ
RKVL---ALDIDDDSFPSSGEEAEATG-----GGGGGGRKVVRCRDDGDEDYYKQRLXXX
XXXXXXXXX-XXXXXXDESEESDAEFDEG-RVPGFLFKKLFK

PF00176 // ENSGT00590000083118_2_Domain_0 (583, 899)

YQQTGVRWLWELHCQQAG
GILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRFEGLGPAVIVCPTTVMHQWVREFHT
WWPPFRVAVLHETGSYTHKKEKLIRDIAHCHGILITSYSYVRLMQDDISRYDWHYVILDE
GHKIRNPNAAITLACK-----QFRTPHRI---IL--SGSPMQNNLRELWSLFDFIFPGKL
GTLPVFMEQFSVPITMGGYSNASPVQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXX--XXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXIFSGLVALRKICNHPDLFS
GGPKNLRGSPDDTLE-EDQFGYWKRSGKMIVVESLLKIWHKQGQRVLLFSQSRQXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXARERAWRIGQKKQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVLKDPKQ
RRFFKSNDLYELFTLTSPDASQSTETSAIF----------------------------AG
TGSEVQTPKRHLKRKVQSAFAVG--RDI---------PKHEKSPDPSTSVHSAT-SS---
---AEEPKATGVAVTA---NE--SDPSK-DGPYPRGDVTSS-DGLGVEG----AAASR--
-LEESSGISGHEKSSDSPRTGKTSRLSAEESS-HEKQGLSYERGK--QGHTEPHWENEQV
ENNFSKHKSKTKHSSTA-EEVLGKLPRLKLKPKKPKYLRDAKFEGTRIPHLVKKRQYRKP
DGDPESEARERSSDDYVLEKLFKKS-VGVHSVMKHDAIMDGASPDYVL---VEAEANRVA
QDALKALRLSRQRCLGAASGVPTWTGHRGVAGAPVGIK--NRFGQKKNSSFSVQRPFSTS
LTEKCQDSITKKE---GKASAQEHFSGRAEDAEPCTGALTSSSLLAKMRARNHLILPERL
ESEDGPLPES--SAPLPSCTEHDDLLVEMRNFIAFQAHVDGQASTQEILQEFESRLSASQ
SCVFRELLRNLCTFHRASSGEGIWKLKPEYC

---------------------------------MPNEGIPDSSQTQEQDYL-----QSQP
ISNNEEMAIKQESG-G--D-GEVEEYLPFSS---VGDGLSTSAEGCASAALRRGPALLHI
NRRQIQAVEPSAQALELQGLGVDVYDQDVLEQGVLRQVDNAIHEASCASQLADVEKEYRS
VLDDLTSCTTSLRQINKIIEQLSPQAATSRDINRKLDSVKRQKYNKEQQLKKITAKQKHL
QAILGGAEVK--IELDHASLE--EDAEPG----PSCLGSMLMPVQETAWEELIRTGQMTP
FGTQIPQKQEKKPRKIMLNEASGFEKYLADQA--KLSFERKKQATCNKRPARKAPASVTP
-PAPAQ----SKSKPNKKAKVLSKKEERLKKHIKKLQKRAL--QFQGKVGLPKARRPWES
DMRPEA-EGDSEGEESEYFPTEEEE--EEEDDEVEGVEADLSGDCTDYELKPLPKGRKQQ
KKVP---VQEIDDDFFPSSGEEAEASPIGEG---GGGGRKVGRYQDDGDEDYYKQRLRRW
NKLRLQDKE-KRLKLEDDSEESDAEFDEGFKVPGFLFKKLFKYQQTGVRW

PF00176 // ENSGT00590000083118_2_Domain_0 (591, 898)

LWELHCQQAG
GILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRFEGLGPTVIVCPTTVMHQWVKEFHT
WWPPFRVAILHETGSYTHKKEKLIRDVAHCHGILITSYSYIRLMQDDISRYDWHYVILDE
GHKIRNPNAAVTLACK-----QFRTPHRI---IL--SGSPMQNNLRELWSLFDFIFPGKL
GTLPVFMEQFSVPITMGGYSNASPVQVKTAYKCACVLRDTINPYLLRRMKSDVKMSLSLP
DKNEQV--LFCRLTDEQHKVYQ--NFVDSKEVYRILNGEMQIFSGLIALRKICNHPD

ENSGT00590000083118_2_Linker_0_1 (898, 935)

LFS
GGPKNLKGLPDDELE-EDQFGYWKRSGKMIVVES

PF00271 // ENSGT00590000083118_2_Domain_1 (935, 1040)

LLKIWHKQGQRVLLFSQSRQMLDILE
VFLRAQKYTYLKMDGTTTIASRQPLITRYNEDTSIFVFLLTTRVGGLGVNLTGANRVVIY
DPDWNPSTDTQARERAWRIGQKKQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVLKDPKQ
RRFFKSNDLYELFTLTSPDASQSTETSAIF----------------------------AG
TGSDVQTPKCHLKRKIQPAFGTD--HDV---------LKRKKFPASNISINDAT-SS---
---EDKSEAKGAEVNVVPSNQ--SDPLK-DDPHMSSNVASN-DRLGEET----NTVSG--
-PEESSVISGNGECSNSSGTGKTSRPSGDESI-EEKLGLSYKRERPNQVQTESFWENKQM
ENNFCKHKSKTKHQSVAEEETLEKHLRPKQKPKNPKQCRDAKFEGTRIPHLVKKRRYRKQ
GSENKSEAKEQSNDDYVLEKLFKKS-VGVHSVMKHDAIMDGASPDYVL---VEAEANRVA
QDALKALRLSRQRCLGAVSGVPTWTGHRGISGAPAGTK--SRFGKKRNSNFSVQHTSSTS
PKEKCQDGIMKKE---GKDNVPEHFSGRAEDADSSSRALASSSLLAKMRARNHLILPERL
ESESRHLQEA--SALL-PTTEHDDLLVEMRNFIAFQAHTDGQASTREILQEFESKLSASQ
SCVFRELLRNLCTFHRTSGGEGIWKLKPEYC

---------------------------------MPYEEIPHSSQAQEQDGF-----QSYH
VNASKETSTEPENG-G--N-GEAEKCLPSPS---SDYGVSTPAEACASVAGRRGPGLLHI
DRHQIPAVEPSAQALELQGLAVDVYDQSVLEQGVLQQVDSAMHEASRATQLADAEKEYRS
VLDDFMSCMKSLRQIDKIIEQLSPQALTSRDISRKLDSVKRQKYNKEQQLKKITAKQKRL
QAILRGAEVQ--VELEHASLEE--DAEPG----PSCLGSMLMPAQETAWDELIRTGQMTP
FGTQVPQKQEKKPRKIMLNEASGFEKYLADQA--KLSFERKKQ-ATNKKVARKAPVLCES
--NTGP----NENRPSQGSKVVSRADQRLKKHMRKLQRRAL--QFQGKVQLPKGKKSLEP
QGGPET-EVDSEGEEFGSFPTEEMEEEE-EEEEEDRTGAELSEDGTDYELKPLHRGRKRQ
KKVL---AQEVDDDFFPSSGEEAEATG---EEGGRGGGRKEARCRDDGDEDYYKQRLRRW
NKLRLQDKV-KCLKLDDDSEESDAEFDEGFKVPGFLFKKLFKYQQTGVRW

PF00176 // ENSGT00590000083118_2_Domain_0 (591, 898)

LWELHCQQAG
GILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRFEGLGPTVIVCPTTVMHQWVKEFHT
WWPPFRVAILHETGSYTHKKEKLVRDIAHCHGILITSYSYIRLMQDAISRYDWHYVILDE
GHKIRNPNAAVTLACK-----QFRTPHRI---IL--SGSPMQNNLRELWSLFDFVFPGKL
GTLPVFMEQFSVPITMGGYSNASPVQVKTAYKCACVLRDTINPYLLRRMKSDVKMSLSLP
DKNEQV--LFCRLTDEQHEVYQ--NFIDSKEVYGILNGDMQIFSGLVALRKICNHPD

ENSGT00590000083118_2_Linker_0_1 (898, 935)

LFS
GGPKNLKGHPDEELE-ENQFGYWKRSGKMIVVES

PF00271 // ENSGT00590000083118_2_Domain_1 (935, 1040)

LLKIWHKQGQRVLLFSQSRQMLHILE
VFLRARNYSYLKMDGSTTIASRQPLIAKYNEDTSIFVFLLTTRVGGLGVNLTGANRVIIY
DPDWNPSTDTQARERAWRIGQKKQVTVYRLLMAGTIEEKIYHRQIFKQFLTNRVLKDPKQ
RRFFKSNDLYELFTLTSPDVSQSTETSAIF----------------------------AG
IGSDVKTPSRCLKRKATPAFRTD--HTI---------PKCTKFPDSNISAKGAT-LT---
---EEEPKAAG----VVTCNE--SGLLK-GALHLGGSSSAG-DSG------EAGMESG--
-PKGLPVASASGDCSDSVRVGRTPGPSGGGST-SEKEGPSCEGES-CPLKTEPLWENGRV
ESHFHKHKSKTKHQDMAGEETPGK-------PMKAKCRRDAKFEGTRIPHLVRKKRYHKQ
DSEQESQATEQNSDDYVLQKLFKKS-VGVHSVVKHDAIVDGTSPDYVL---VEAEASRVA
QEALKALKLSRQRCLGAASGVPTWTGHRGTSGAPAGIK--SRFGQKRNSKLTVQSPSSAS
PTQKCQDSTLKKE---GKDGALEHFSGKAEEAESSSRALASSLLLARMRARNHLILPERL
ESDSGLLPET--SAPLPTATEHDDLLVEMRNFIAFQAHVDGQASTQEILQEFESKLSTSQ
SCVFRELLRNLCTFHRTSGGEGIWKLKPEYC

---------------------------------MPNERIPDSSQTEEQDCL-----QSRC
VSDGEKMTVKQEND-G--D-AEMEESLPSCS---SANGPSISTEGCPWEVPRRRPALLHI
DRHQIQAVEPSAQALELQGLGVDVYDQDVLEQGVLQQVDSAIHEASHAAQLLDAEKEYQS
VLDDLTSCTTSLRQINKIIEQLSPQAATNRDINRKLDSVKRQKYNKEQQLKKITAKQKRL
QALLGGVAVN--AELDHASVEE-EDAEAG----PSCLGSMLMPAQETAWEELIRTGQMTP
FGTQIPQKQEKKPRKLMLNEASGFEKYLADQA--KLSFERKKQ-ACNKRASRKTPALVTS
ELSPTL----SENKPNKRSKVLSKTDKRLKKHIKKLQKRAL--QFQGKVGLPKGKKHLES
DVRPKA-EGDSEGEESEYLPTEEEERE-------AAAEVDLSAEGTDSELGPVLKRRKWQ
KKIT---VQEIDDESF---GEEAEAAK-----G--GGGRKVVRCRDDGDEDYYKQRLRRW
NKLRLQDKE-KCLKLEDDSEESDAEFD-EFKVPGFLFKKLFK

PF00176 // ENSGT00590000083118_2_Domain_0 (583, 899)

YQQTGVRWLWELHCQQAG
GILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRFEGLGPTIIVCPTTVMHQWVKEFHT
WWPPFRVAVLHETGSYTHRKEKLIRDIAHCHGILITSYSYIRLRQDDISRHDWHYVILDE
GHKIRNPNAAITLACK-----QFRTPHRI---IL--SGSPMQNNLRELWSLFDFVFPGKL
GTLPVFMEQFSVPITMGGYSNASPVQVKTAYKCACVLRDTINPYLLRRMKSDVKMSLSLP
DKNEQV--LFCRLTDEQHKVYQ--NFIDSKEVYRILNGEMQVFSGLVALRKICNHPDL

ENSGT00590000083118_2_Linker_0_1 (899, 962)

FS
GGPKTPRGISDNEPE-EDQFGHWRRSGKMIVVESLLKIWHKQGQRVLLFSQSRQMLDILE
V

PF00271 // ENSGT00590000083118_2_Domain_1 (962, 1040)

FLRAQKYSYLKMDGTTTIASRQPLITRYNEDTSIFVFLLTTRVGGLGVNLTGANRVIIY
DPDWNPSTDTQARERAWRIGQRKQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVLKDPKQ
RRFFKSNDLYELFTLTSPDASQGTETSAIF----------------------------AG
TGSDVQTPKRHLKRKLQLAFGAD--HNI---------PIGKKFPDSDASASDGT-AS---
---AEKSAAVGAAVNAAPSNQ--GDPLG-EAPRTPGTGARG-DRLAEET----DAVIR--
-LEDGPVPSAQGQCSRSPGTSDTGRTSGGERI-GEKQGLPDKRES-CQVQTEPLWENGQM
DNNFCKHKSKTKH-SVAEE-TQETLLRPKQKPKSSKCRRDAKFEGTRIPHLVKKRKYRKQ
DSENEQESKQQDNDDYVLEKLFKKS-VGVHSVMKHDAIMDGASPDYVL---VEAEANRVA
QDALKALRLSRQRCLGVASGVPTWTGHRGVSGAPAGTK--SRFGQKRNSSFSVQHPSSTS
PKQKHQDGIVKKD---GKDHISEHFSGNSEAAESSSGALASSSLLAKMRARNHLILPERL
ESENVHPPEA--CAPPPSSAEHDDLLVEMRNFIAFQARVDGQASTQEILQEFESKLTVSQ
SCVFRELLRNLCTFHRTSGGEGIWKLKPEYC

---------------------------------MPHEEIPNSTQPQGQDWL-----PGQH
VSADRDIPAGQETA-G--D-SEAGKCLSSPS---CDHGPSTSAEACVLAATRWGPALLHI
DRHQIPAVEPSAQALELQGLGVDVYDQAVLEEGVLQQVDSAMHEASRVAQRADAEKEYQS
VLDDLMSCTTSLRQINKIIEQLSPQAASNRDINRKLDSVKRQKYNKEQQLKKITAKQKRL
QAILGGAEVH--VELDHGSLEE-EDAEPG----PSCLGSMLMPAQESAWEELIRTGQMTP
FGTPAPQKQEKKPRKIMLNEASGFEKYLADQA--QLSFKRKKQ-AANKRTAKKAV--VVS
ESSRGP----NETKPNQRSQALSQTDKRLKKHIRKLQRRAL--QFQGKVGLQRGKRPLEP
EERPGA-EGDTEGEESGSSPTDGEEEEEQ-E---EEGVAVLSSDDISYELKPLRKGQKYE
KKVP---VQEIDDDFFPSSEEEDEAVE------GRGGGRKVSRRPDDGDEDYYKQRLRRW
NRLRLQDKE--KLKLEDDSEESDAEFDEGFKVPGFLFKKLFKYQQTGVRW

PF00176 // ENSGT00590000083118_2_Domain_0 (591, 898)

LWELHCQQAG
GILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRFEGLGPTLIVCPTTVMHQWVKEFHT
WWPPFRVAILHETGSCAHRKERLVRDIVHCHGVLITSYSYIRLMQDDISRHDWHYVILDE
GHKIRNPNAAVTLACK-----QFRTPHRI---IL--SGSPMQNNLRELWSLFDFTFPGKL
GTLPVFMEQFSVPITMGGYSNASPVQVKTAYKCACVLRDTINPYLLRRMKSDVKMSLSLP
DKNEQV--LFCRLTDEQHKVYQ--NFIDSKAVYRILNGENQIFSGLVALRKICNHPD

ENSGT00590000083118_2_Linker_0_1 (898, 935)

LFS
GGPKNTSALPEDGLE-EEQFGYWKRSGKMIVVES

PF00271 // ENSGT00590000083118_2_Domain_1 (935, 1040)

LLKIWHKQGQRVLLFSQSRQMLHILE
VFLRAHKYSYLKMDGTTTIASRQPLITKYNEDTSIFVFLLTTRVGGLGVNLTGANRVIIY
DPDWNPSTDTQARERAWRIGQKKQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVLKDPKQ
RRFFKSNDLYELFTLTSPDASQGTETSAIF----------------------------AG
TGSNIQTLKCHFKKRTPPVLQMD--------------PKRKKPLVSDTSVNGAT-VM---
---EEKSQGSGATG-SVPSTE--SGPLK-SDRHTDGSRASS-VGFGEEA----DAGST--
-LEHLSGL-----SGDSPAVDHTSRLSAVAST-SEKQGSSYEGEC-CQAQTGPVHLSEQT
EGHFSKHKSKRKH-DAAEEETTEKCPQPKQKAKNSRHHRDAKFEGTRVPHLVKKRRYHQQ
TTEQESGAKDRSSDDYVLEKLFKKS-VGVHSVVKHDAIIDGSSPDYVL---VEAEANRVA
QDALKALRLSRQQCLGATSGVPTWTGHRGISGAPAGVK--KRFGQKRNSSLPVQRPSS--
LTERTQ-N-MKKE---GEAHTAEHFSGKEDGA-SSSGAPSSSSLLARMRARNHMILPERL
ESDGEQLAGAAAAAAPPCSTEHDALLVDMRNFIAFQAQVDGQASTQEILQAFESKLSVAQ
SCVFRELLRNLCNFHRTPGGEGIWKLKPEYC

---------------------------------MPNEGIPHSSQTQEQDCL-----QSQP
VSNNEEMAIKQESG-G--D-GEVEEYLSFRS---VGDGLSTSAVGCASAAPRRGPALLHI
DRHQIQAVEPSAQALELQGLGVDVYDQDVLEQGVLQQVDNAIHEASRASQLVDVEKEYRS
VLDDLTSCTTSLRQINKIIEQLSPQAATSRDINRKLDSVKRQKYNKEQQLKKITAKQKHL
QAILGGAEVK--IELDHASLE--EDAEPG----PSSLGSMLMPVQETAWEELIRTGQMTP
FGTQIPQKQEKKPRKIMLNEASGFEKYLADQA--KLSFERKKQ-GCNKRAARKAPAPVTP
-PAPVQ----NKNKPNKKARVLSKKEERLKKHIKKLQKRAL--QFQGKVGLPKARRPWES
DMRPEA-EGDSEGEESEYFPTEEEE--EEEDDEVEGAEADLSGDGTDYELKPLPKGGKRQ
KKVP---VQEIDDDFFPSSGEEAEAASVGEG---GGGGRKVGRYRDDGDEDYYKQRLRRW
NKLRLQDKE-KRLKLEDDSEESDAEFDEGFKVPGFLFKKLFKYQQTGVRW

PF00176 // ENSGT00590000083118_2_Domain_0 (591, 898)

LWELHCQQAG
GILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRFEGLGPTVIVCPTTVMHQWVKEFHT
WWPPFRVAILHETGSYTHKKEKLIRDVAHCHGILITSYSYIRLMQDDISRYDWHYVILDE
GHKIRNPNAAVTLACK-----QFRTPHRI---IL--SGSPMQNNLRELWSLFDFIFPGKL
GTLPVFMEQFSVPITMGGYSNASPVQVKTAYKCACVLRDTINPYLLRRMKSDVKMSLSLP
DKNEQV--LFCRLTDEQHKVYQ--NFVDSKEVYRILNGEMQIFSGLIALRKICNHPD

ENSGT00590000083118_2_Linker_0_1 (898, 935)

LFS
GGPKNLKGLPDDELE-EDQFGYWKRSGKMIVVES

PF00271 // ENSGT00590000083118_2_Domain_1 (935, 1040)

LLKIWHKQGQRVLLFSQSRQMLDILE
VFLRAQKYTYLKMDGTTTIASRQPLITRYNEDTSIFVFLLTTRVGGLGVNLTGANRVVIY
DPDWNPSTDTQARERAWRIGQKKQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVLKDPKQ
RRFFKSNDLYELFTLTSPDASQSTETSAIF----------------------------AG
TGSDVQTPKCHLKRRIQPAFGAD--HDV---------PKRKKFPASNISVNDAT-SS---
---EEKSEAKGAEVNAVTSNR--SDPLK-DDPHMSSNVTSN-DRLGEET----NAVSG--
-PEELSVISGNGECSNSSGTGKTSMPSGDESI-DEKLGLSYKRERPSQAQTEAFWENKQM
ENNFYKHKSKTKHHSVAEEETLEKHLRPKQKPKNSKHCRDAKFEGTRIPHLVKKRRYQKQ
DSENKSEAKEQSNDDYVLEKLFKKS-VGVHSVMKHDAIMDGASPDYVL---VEAEANRVA
QDALKALRLSRQRCLGAVSGVPTWTGHRGISGAPAGKK--SRFGKKRNSNFSVQHPSSTS
PTEKCQDGIMKKE---GKDNVPEHFSGRAEDADSSSGPLASSSLLAKMRARNHLILPERL
ESESGHLQEA--SALL-PTTEHDDLLVEMRNFIAFQAHTDGQASTREILQEFESKLSASQ
SCVFRELLRNLCTFHRTSGGEGIWKLKPEYC

---------------------------------MFHEEVPNSTHPQEQDCL-----PSQH
ANAYKDMPVGQECG-G--V-SEAGECLSSTS---CEYGPSTSAEACMLAATRRGPTLLHI
DRHQIPAVEPSAQALELQGLGVDVYDQAVLEQGVLQQVDSAMHEASRVAQLADAEKEYQS
VLDDLMSCSTSLRQINKIIEQLSPQAASNRDINRKLDSVKRQKYNKEQQLKKITAKQKRL
QAILGGAGVQ--VELDHASLEE-EDAEPG----PSCLGSMLMPAQETAWEELIRTGQMTP
FGTPAPQKQEKKPRKIMLNEASGFEKYLAEQA--QLSFERKKQ-AATKRTAKKAV--VMS
ESSRAA----NETKADQRGQVLSQTDKRLKKHIRKLQKRAL--QFQGKVGLPRGKKPLEP
EVRPEA-EGDTEGEESGSSPTDGEEEEEQEE---EEGVASLSSDDISYELKPLRKRQKYQ
KKVP---VQEIDDDFFPSSEGEDEAME------GRGGGCKVAKRQDDGDEDYYKQRLRRW
NRLRLQDKE-KRLKLEDDSEESDAEFDEGFKVPGFLFKKLFKYQQTGVRW

PF00176 // ENSGT00590000083118_2_Domain_0 (591, 898)

LWELHCQQAG
GILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRFEGLGPTIIVCPTTVMHQWVKEFHT
WWPPFRVAILHETGSYAHKKERLIRDIVHCRGVLITSYSYIRLMQDDISRHDWHYVILDE
GHKIRNPNAAVTLACK-----QFRTPHRI---IL--SGSPMQNNLRELWSLFDFIFPGKL
GTLPVFMEQFSVPITMGGYSNASPVQVKTAYKCACVLRDTINPYLLRRMKSDVKMSLSLP
DKNEQV--LFCRLTDEQHKIYQ--NFIDSKEVYRILNGENQIFSGLVALRKICNHPD

ENSGT00590000083118_2_Linker_0_1 (898, 936)

LFS
GGPKNVSGLPEDELE-EEQFGHWRRSGKMIVVESL

PF00271 // ENSGT00590000083118_2_Domain_1 (936, 1040)

LKIWQRQGQRVLLFSQSRQMLHILE
VFLRAHKYSYLKMDGTTTIASRQPLITKYNEDTSIFVFLLTTRVGGLGVNLTGANRVIIY
DPDWNPSTDTQARERAWRIGQKKQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVLKDPKQ
RRFFKSNDLYELFTLTSPDASQGTETSAIF----------------------------AG
TGSNIQTPKCHLKKRTSPVLGTD--------------PKCKKPPVSDTPANAAT-LI---
---GEKPKAAGATGRSVSSAE--SGPFK-GDRHTNGDRASS-VALGEET----GAGSM--
-LEHLSVMSEDGKCSDSPTVDHTSRPSIEVST-SEKQGSSNEGEC-CQAQTEPVHMSEQM
EGQFSKYKSKRKH-DASEEETTEKRPQPKQKAKNSKHCRDAKFEGSRVPHLVKKRRYRQQ
TSEQEGGAKDRSSDDYVLEKLFKKS-VGVHSVVKHDAIIDGSSPDYVL---VEAEANRVA
QDALKALRLSRQQCLGAASGVPTWTGHRGISGAPTGVK--NRFGQKRNANLPAQRPSS--
LTEKTQSN-MRKE---GKAHTPEHFSGKEDGA-SLSGAPSSSSLLARMRARNHMILPERL
ESDGEHLAEA--AAVPPCGTEHDDLLVDMRNFIAFQAQVDGQASTQEILQEFESKLSVAQ
SCVFRELLRNLCNFHRTPGGEGIWKLKPEYC

---------------------------------MPNETIPHSGQSEEKDYS-----NGQF
FSNAEETAYGPENGGAL---DKMEESFTSST---YDNRPSTSSVVGMFEVPRKGQPLLHI
NRQQIQSVEHSAQAVELKGLGVDVYDQEVLEQGVLQQVDNAINEANRAAQLAEAEKEYHS
VLDDLRSCTTSLKQIDTIIEHLSPQAVNNKDVNRKLDSVKRQKCNKEKQLKKIKAKQKRL
QAILGTERD---IEANLVDLE--EDEEPG----PSSLGSMLMPIQETEWEELIRTGQMTP
FGTRIPQNQKKRPRKLMLNEASGFEKYLADQA--KLSFEKKKL--CKKRRKT----SVAS
NVISTS----KRKEPDQ--WEALKTDKRLKKHIKKLQRRAV--QFQGKVGFLKEKKPLEP
KSPN---MKGDESEDSEYLFTEEEEEEE--------EQALHATNKRNHKLKLLSKDRKQQ
NKIP---VEEIDDDCLPSSGEEGSI----------GRNGKIKRCRDDGDEDYYKQRLRRW
NKQRLEDKE-QRRKAEEESEESDAEFDEGFRVPGFLFKKLFK

PF00176 // ENSGT00590000083118_2_Domain_0 (583, 959)

YQQTGVRWLWELHCQQAG
GILGXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXX----XXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXFRTPHRI---IL--SGSPMQNNLKELWSLFDFVFPGKL
GTLPVFMEQFSVPITMGGYSNASPVQVKTAYKCACVLRDTINPYLLRSMKTDVKMSLSLP
DKNEQV--LFCRLTDEQRKVYQ--NFIDSKEVYRILNGEMQXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXHKQGHRVLLFSQSRQMLHL

ENSGT00590000083118_2_Linker_0_1 (959, 962)

LE
A

PF00271 // ENSGT00590000083118_2_Domain_1 (962, 1033)

FLRVREYSYLKMDGTTTIASRQPLITRYNEDTSVFVFLLTTRVGGIGINLTGANRVIIY
DPDWNPSTDTQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXQIFKQFLTNRILKDPKQ
RRFFKSNDLYELFTLSSPDESQGTETSAIF----------------------------AG
TGSDVQAPKHHLKRKFQTFREGMCQADV--------SPECSKLSDVNISEAIAG------
-SSQEKYKDKETDVNLGTFSQ------------SSVSVERVETHLIEEKCALKNTFSASD
EPSKIVMTLGNGENLNSXXXXXXXXXXXXXXX----------------------------
------------X-X-----X----------XX-XX-XXXX-------------------
-------XXX-----XXX-XXXXXX--XXXXXX---------------------------
----------------XXXXXXXXXXXXXXXXXXXXXXXXSRFGQKRNPSLPVPQSSSKS
AKEKCQ------------------------------------------------------
------------------------------------------------------------
-------------------------------

---------------------------------MPNEGIPHSSQTQEQDCL-----QSQP
VSNNEEMAIKQESS-G--D-GEMEEYLHSHS---VGDGLFTSAEGCASAAPRRGPALLHI
DRHQIQAVEPSAQALELQGLGVDVYDQDVLEQGVLQQVDNAIHEASCASQLADAEKEYRS
VLDDLASCTTSLRQIDKIIEQLNPQAAPSRDINRKLDSVKRQKYNKEQQLKKITAKQKRL
QAILGGAEVK--VELDHASLEE-EDAEPG----PSSLGSMLMPVQETAWEELIRTGQMTP
FGTRIPQKQEKKPRKIMLNEASGFEKYLADQA--KLSFERKKQ-ACNKRAARKAPAPVMS
-PAPMQ----NKNKPSKKTKVLSKKEERLKKHIKKLQKRAL--QFQGKVGLPKTRRPWES
DMRPQV-EGDSGGEESEYFPTEEE-----EDDEVEGVEADLSGDGKDYELKPLPKGRKRQ
KKVP---VQEIDDDFFPSSGEEAEASPVGGGG--GGGGRKVGRYRDDGDEDYYKQRLRRW
NKLRLQDKE-KRLKLEDESEESDAEFDEGFKVPGFLFKKLFKYQQTGVRW

PF00176 // ENSGT00590000083118_2_Domain_0 (591, 898)

LWELHCQQAG
GILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRFEGLGPTVIVCPTTVMHQWVKEFHT
WWPPFRVAILHETGSYTHKKEKLIRDVAHCHGILITSYSYIRLMQDDISRYDWHYVILDE
GHKIRNPNAAVTLACK-----QFRTPHRI---IL--SGSPMQNNLRELWSLFDFIFPGKL
GTLPVFLEQFSVPITMGGYSNASPVQVKTAYKCACVLRDTINPYLLRRMKSDVKMSLSLP
DKNEQV--LFCRLTDEQHKVYQ--NFIDSKEVYRILNGEMQIFSGLIALRKICNHPD

ENSGT00590000083118_2_Linker_0_1 (898, 935)

LFS
GGPKNLKGLPDDELE-EDQFGYWKRSGKMIVVES

PF00271 // ENSGT00590000083118_2_Domain_1 (935, 1040)

LLKIWHKQGQRVLLFSQSRQMLDILE
VFLRAQKYTYLKMDGTTTIASRQPLITRYNEDTSIFVFLLTTRVGGLGVNLTGANRVIIY
DPDWNPSTDTQARERAWRIGQKKQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVLKDPKQ
RRFFKSNDLYELFTLTSPDASQSTETSAIF----------------------------AG
TGSDVQTPKCHLKRKIQPAFGAD--HDI---------PKHKKFPASNIPVNDAT-SS---
---EEKPKAKGGEVNAVTSSQ--SDPLK-DDPHTSSNVTSN-DRLGEET----NAVSG--
-PEESSVISGNGECSNSSRTGKTSRLSGDESI-DEKLGLPHEREIPSQAQTESFWENKQM
ENKFYKHKSKTKHHNAAEEKIPEKHLRPKQKSEKPKHCRDAKFEGTRIPHLVKKRRYQKQ
DAENKSEAKEQSNDDYVLEKLFKKS-VGVHSVMKHDAIMDGASPDFVL---VEAEANRVA
QDALKALRLSRQRCLGAVSGVPTWTGHRGISGAPAGTK--SRFGKKRNSNFSVQHPSSKS
TAEKCQDGVMKKE---GKDNVPGHFSGRAEDAESSSGALASSSLLAKMRARNHLILPERL
ESESGHLQEA--SAPL-PTTEHDDLLVEMRNFIAFQAHTDGQASTREILQEFESKLSASQ
SCVFRELLRNLCTFHRTSGGEGVWKLKPEYC

---------------------------------MPNEGIPHSSQTQEQDCL-----QSQP
VSNNEEMAIKQESS-G--D-GEMEEYLHSHS---VGDGLFSTAEGCASAAPRRGPALLHI
DRHQIQAVEPSAQALELQGLGVDVYDQDVLEQGVLQQVDNAIHEASCASQLADAEKEYQS
VLDDLTSCTTSLRQIDKIIEQLSPQAATSRDINRKLDSVKRQKYNKEQQLKKITAKQKRL
QAILGGAEVK--VELDHASLEE-EDAEPG----PSSLGSMLMPVQETAWEELIRTGQMTP
FGTQIPQKQEKKPRKIMLNEASGFEKYLADQA--KLSFERKKQ-ACNKRAARKAPAPVMS
-PAPMQ----NKNKANKKTKVLSKKEERLKKHIKKLQKRAL--QFQGKVGLPKTRRPWES
DMRPQA-EGDSGGEESEYFPTEEEEE-EEEDDEVEGVEADLSGDGTDYELKPLPKGRKRQ
KKVP---VQEIDDDFFPSSGEEAEASPVGGGGGGGGGGRKVGRYRDDGDEDYYKQRLRRW
NKLRLQDKE-KRLKLEDDSEESDAEFDEGFKVPGFLFKKLFKYQQTGVRW

PF00176 // ENSGT00590000083118_2_Domain_0 (591, 898)

LWELHCQQAG
GILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRFEGLGPTVIVCPTTVMHQWVKEFHT
WWPPFRVAILHETGSYTHKKEKLIRVVAHCHGILITSYSYIRLMQDDISRYDWHYVILDE
GHKIRNPNAAVTLACK-----QFRTPHRI---IL--SGSPLQNNLRELWSLFDFIFPGKL
GTLPVFLEQFSIPITMGGYSNASPVQVKTAYKCACVLRDTINPYLLRRMKSDVKMSLSLP
DKNEQV--LFCRLTDEQHKVYQ--NFIDSKEVYRILNGEMQIFSGLIALRKICNHPD

ENSGT00590000083118_2_Linker_0_1 (898, 935)

LFS
GGPKNLKGLPDDELE-EDQFGYWKRSGKMIVVES

PF00271 // ENSGT00590000083118_2_Domain_1 (935, 1040)

LLKIWHKQGQRVLLFSQSRQMLDILE
VFLRARKYTYLKMDGTTTIASRQPLITRYNEDTSIFVFLLTTRVGGLGVNLTGANRVVIY
DPDWNPSTDTQARERAWRIGQKKQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVLKDPKQ
RRFFKSNDLYELFTLTSPDASQSTETSAIF----------------------------AG
TGSDVQTPKCRLKRKIQPAFGAD--HDI---------PKHKKFPASNVVVNDAT-SS---
---EEKPKAKGGEVNAVTSSQ--SDPLK-DDPHTSSNVTSN-DRLGEET----NAVSG--
-PEESSVISGNGECSNSSRTGNTSKLCGNESI-NEKLGVSYKREIPSQAQTESFWENKQM
ENKFYKHKSKTKHHNAAEEKTLEKHLRPKQKSKNSKHCRDAKFEGTRIPHLVKKRRYQKQ
DTENKSEAKEQSNDDYVLEKLFKKS-VGVHSVMKHDAIMDGASPDFVL---VEAEANRVA
QDALKALRLSRQRCLGAVSGVPTWTGHRGISGAPAGTK--SRFGKKRNSNFSVQHPSSKS
PAEKCQDGVMKKE---GKDNVPGHFSGRAEDAESSSGALASSSLLAKMRARNHLILPERL
ESESGHLQEA--SVSL-PTTEHDDLLVEMRNFIAFQAHTDGQASTREILQEFESKLSASQ
SCVFRELLRNLCTFHRTSGGEGIWKLKPEYC

---------------------------------MQNARISNSSSTQEQDGL-----QSQY
VNDKQEMTIKQEND-G--S-VEVEESLPSCS---SANGPSNSAEGCSSEVSRRGSALLHI
NRHHIQTVEPSAQALELQGLGVDVYDQDVLEQGVLRQVDSAIHEASRAAQLADAEKEYRS
VLDDLTSCTTSLRQINKIIEQLSPQAATNRDINRKLDSVKRQKYNKEQQLKKITAKQKRL
QAILGGAEVQ--VEVDHASLEE-EDIEPG----PSCLGSMLMPAQETAWEELIRTGQMTP
FGTQIPQKQEKKPRKLMLNEASGFEKYLADQA--KLSFERKKQ-ACSKRASRKTPASVTS
ELSTAL----HENKPNEQSKGLSKTDKRLKKHMKKLQKRAL--HFQGKVGLPKGKKPLES
DVRPKV-EGSSEGEESEYLPTEEELE--------EAEEAKLTAEDTDYELKPVLKHRKRQ
KKVT---GQEIEDDFLPSSGEEAEAAC-----G--GRSRKVVRCRDDGDEDYYKQRLRRW
NKLRLRDKE-KSLKLEDDSEESDAEFD-DFKMPGFLFKKLFK

PF00176 // ENSGT00590000083118_2_Domain_0 (583, 897)

YQQTGVRWLWELHCQQAG
GILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRFKGLGPTIIVCPTTVMHQWVKEFHT
WWPPFRVAILHETGSYAHKKEKLIRDIAHCHGILITSYSYIRLMQDDISRHDWHYVILDE
GHKIRNPNAAVTLACK-----QFRTPHRI---IL--SGSPMQNNLRELWSLFDFIFPGKL
GTLPVFMEQFSVPITMGGYSNASPVQVKTAYKCACVLRDTINPYLLRRMKSDVKMSLSLP
DKNEQV--LFCRLTEEQHKVYQ--NFIDSKEVYRILNGDMQIFSGLVALRKICNHP

ENSGT00590000083118_2_Linker_0_1 (897, 962)

DLFS
GGPKNAKGIPDDELE-EDQFGYWKRSGKMIVVESLLKIWHKQGQRVLLFSQSRQMLDILE
V

PF00271 // ENSGT00590000083118_2_Domain_1 (962, 1040)

FLRAQKYSYLKMDGTTAIASRQPLITRYNEDPSIFVFLLTTRVGGIGVNLTGANRVIIY
DPDWNPSTDTQARERAWRIGQKKQVTVYRLLTAGTIEEKIYHRQIFKQFLANRVLKDPKQ
RRFFKSNDLYELFTLTSPDPSQSTETSAIF----------------------------AG
TGSEVQASKLHLKRKLPPAFGAD--HDV---------PICKKFPDSTASTNEAP-ST---
---EEKSTATGAEVNAVTSDP--GDPLN-DAPQTPRNLPGS-DGPREGT----KAVSR--
-LEESAVINGQGDCPDSPRISKPDGVSSEESI-HEKQGLSDGREN-CQAQTEPLWEKKQS
EGNFCKHKSKTKH-SAPEEEPPEQPGRPAQKLKSSKHRRDAKFEGTRIPHLVKKRRYHQR
DSENENESSEQSNEDYVLEKLFKKS-VGVHSVMKHDAIMDGASPDYVL---VEAEANRVA
QDALKALRLSRQRCLGAASGVPTWTGHRGISGAPAGIK--SRFGQKRNSNISVQHPSSTG
SKEKCQDGVTRKD---GKDNASEHFSGKMEDAESSPAALSSSSLLAKMRARNHLILPERL
ESENT-HHEA--SAPPPSTTEHDDLLVDMRNFIAFQAHVDGQASTREILQEFESKLSASQ
SCVFRELLRNLCTFHRTSNGEGIWKLKPEYC

---------------------------------MSDERVFHSCQTQEQDSL-----QGQS
VSGHVEMTVKQENND----HAEMEEDLPSCS---SANVPSTSMEGCPLELPRKGLSLLHI
DRHQIQAVEPSAKALEL-GWGVDVYDQDVLKQGVLQQVDSAXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXX--XXXXXXXXXXXXXXXPG----PSCLGSMLMPVQETAWEELIRTGQMTP
FGTQIPQKQEKKPRKLMLNEASDFEKYLADQA--KLSFERKKQ-ASTKKATRKAPTSVL-
-LSRVQ----SENKPNKKSQVLSRTDKRLKKHMKKLQKRAL--QFQGKVGLVKRKKSLES
DVRPKT-KGDSEDEESEYLPSEVEQE--------EAEGAELSGEDTDCELRPVLKH--RQ
KKVI---KQEVDDDFLPSSGEETEAET------ATGGRRKAVRCRDDGDEDYYKQRLRKW
NKLRLQDKE-KSLRHEEDSEESDAEFDEGFKMPGFLFKKLFK

PF00176 // ENSGT00590000083118_2_Domain_0 (583, 899)

YQQTGVRWLWELHCQQAG
GILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRFEGLGPALIVCPTTVMHQWVKEFHT
WWPPFRVAILHETGSSSHKKERLIRDIAHCHGILITSYSYIRLMQDDISRHDWHYVILDE
GHKIRNPNAAVTLACK-----QFRTPHRI---IL--SGSPMQNNLRELWSLFDFIFPGKL
GTLPVFMEQFSVPITMGGYSNASPVQVKTAYKCACVLRDTINPYLLRRMKSDVKMSLSLP
DKNEQV--LFCRLTDEQHKVYQ--NFIDSKEVYGILNGDMQIFSGLVALGKICNHPDL

ENSGT00590000083118_2_Linker_0_1 (899, 962)

FS
GGPKNLRGPADDVLE-EDQFGYWKRSGKMIVVESLLKIWHKQGQRVLLFSQSRQMLHILE
V

PF00271 // ENSGT00590000083118_2_Domain_1 (962, 1040)

FLRAQKYTYLKMDGTTTIASRQPLISRYNEDTSIFVFLLTTRVGGIGVNLTGANRVIIY
DPDWNPSTDTQARERAWRIGQKKQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVLKDPKQ
RRFFKSNDLYELFTLTSPDASQSTETSAIF----------------------------AG
TGSDVQTPKHHLKRKSPPAFETD--HNA---------LISQTFPDSNASTNDAT-SS---
---EEKSMTIGAVDRAVPSNQ--GILLE-DSPQAPFNLTSN-DRL-------------ET
RPEDSSVTSENGECSDSLKTSTISTTPCIKTI-EGKSGLPDKRER-FQIQTELLCENKQI
ENNFSKHKSKTKHSM--AEETMEKQSRRKQKPKHSKHCGDAKFEGTRISHLVKKRRYQKQ
DNEN--ETIEKSNDDYVLEKLFKKS-VGVHSVMKHDAIMDGANPDYVL---VEAEANRVA
QDALKALKLSRQRCLGAVSGVPTWTGHRGISGAPAGIK--SRFGQKRNSRFSVQHPSSVS
TKEKCQXXXXXXX---XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXX--XXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXICKLKPKC-

---------------------------------MPNEGIPHSSQTQEQDYL-----QSQP
VSNNEEMAIKQESG-G--D-GEVEEYLPFSS---VGDGPSTSAEGCASAASRRGPALLHI
NRHQIQAVEPSAQALELQGLGVDVYDQDVLEQGVLRQVDNAIHEASRTSQLADVEKEYRS
VLDDLTSCTTSLRQINKIIEQLSPQAATSRDINRKLDSVKRQKYNKEQQLKKITAKQKHL
QAILGGAEVK--IELDHASLE--EDAEPG----PSSLGSMLMPVQETAWEELIRTGQMTP
FGTQIPQKQEKKPRKIMLNEASGFEKYLADQA--KLSFERKKQATCNKRPARKAPASVTP
-PAPTQ----SKNKPNKKAKVLSKKEERLKKHIKKLQKRAL--QFQGKVGLPKARRPWES
DMRPEA-EGDSEGEESEYFPTEEEEEEEEEDDEVEGVEADLSGDGTDYELKPLPKGRKRQ
KKVP---VQEIDDDFFPSSGEEAEASPIGEG---GGGGRKVGRYRDDGDEDYYKQRLRRW
NKLRLQDKE-KRLKLEDDSEESDAEFDEGFKVPGFLFKKLFKYQQTGVRW

PF00176 // ENSGT00590000083118_2_Domain_0 (591, 898)

LWELHCQQAG
GILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRFEGLGPTVIVCPTTVMHQWVKEFHT
WWPPFRVAILHETGSYTHKKEKLIRDVAHCHGILITSYSYIRLMQDDISRYDWHYVILDE
GHKIRNPNAAVTLACK-----QFRTPHRI---IL--SGSPMQNNLRELWSLFDFIFPGKL
GTLPVFMEQFSVPITMGGYSNASPVQVKTAYKCACVLRDTINPYLLRRMKSDVKMSLSLP
DKNEQV--LFCRLTDEQHKVYQ--NFVDSKEVYRILNGEMQIFSGLIALRKICNHPD

ENSGT00590000083118_2_Linker_0_1 (898, 935)

LFS
GGPKNLKGLPDDELE-EDQFGYWKRSGKMIVVES

PF00271 // ENSGT00590000083118_2_Domain_1 (935, 1040)

LLKIWHKQGQRVLLFSQSRQMLDILE
VFLRAQKYTYLKMDGTTTIASRQPLITRYNEDTSIFVFLLTTRVGGLGVNLTGANRVVIY
DPDWNPSTDTQARERAWRIGQKKQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVLKDPKQ
RRFFKSNDLYELFTLTSPDASQSTETSAIF----------------------------AG
TGSDVQTPKCHLKRKIQPAFGAD--HDV---------PKRKKFPASNISINDAT-SS---
---EEKSEAKGAEVNVVPSNQ--SDPLK-DDPHMSSNIASN-DRLGGET----NAVSG--
-LEESSVISGNRECSNSSGTGKTSRPSGDESI-DEKLGLSYKRERPSQAQTESFWENKQM
ENNFYKHKSKTKHHSVAEEETLEKHLRPKQKPKNPKHCRDAKFEGTRIPHLVKKRRYQKQ
DSENKSEAKEQSNDDYVLEKLFKKS-VGVHSVMKHDAIMDGASPDYVL---VEAEANRVA
QDALKALRLSRQRCLGAVSGVPTWTGHRGISGAPAGTK--SRFGKKRNSNFSVQHSSSTS
PTEKCQDGIMKKE---GKDNVPEHFSGRAEDADSSSGALASSSLLAKMRARNHLILPERL
ESESGHLQEA--SALL-PTTEHDDLLVEMRNFIAFQAHTDGQASTREILQEFESKLSASQ
SCVFRELLRNLCTFHRTSGGEGIWKLKPEYC

---------------------------------MPNEGIPHSSQTQEQDYL-----QSQP
VSNNEEMAIKQESG-G--D-GEVEEYLPFSS---VGDGLSTSAEGCASAAPRRGPALLHI
NRHQIQAVEPSAQALELQGLGVDVYDQDVLEQGVLRQVDNAIHEASRTSQLADVEKEYRS
VLDDLTSCTTSLRQINKIIEQLSPQAATSRDINRKLDSVKRQKYNKEQQLKKITAKQKHL
QAILGGAEVK--IELDHASLE--EDAEPG----PSSLGSMLMPVQETAWEELIRTGQMTP
FGTQIPQKQEKKPRKIMLNEASGFEKYLADQA--KLSFERKKQATCNKRPARKAPASVTP
-PAPTQ----SKNKPNKKAKVLSKKEERLKKHIKKLQKRAL--QFQGKVGLPKARRPWES
DMRPEA-EGDSEGEESEYFPTEEEE--EEEDDEVEGVEADLSGDRTDYELKPLPKGRKRQ
KKVP---VQEIDDDFFPSSGEEAEASPIGEG---GGGGRKVGRYRDDGDEDYYKQRLRRW
NKLRLQDKE-KRLKLEDDSEESDAEFDEGFKVPGFLFKKLFKYQQTGVRW

PF00176 // ENSGT00590000083118_2_Domain_0 (591, 898)

LWELHCQQAG
GILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRFEGLGPTVIVCPTTVMHQWVKEFHT
WWPPFRVAILHETGSYTHKKEKLIRDVAHCHGILITSYSYIRLMQDDISRYDWHYVILDE
GHKIRNPNAAVTLACK-----QFRTPHRI---IL--SGSPMQNNLRELWSLFDFIFPGKL
GTLPVFMEQFSVPITMGGYSNASPVQVKTAYKCACVLRDTINPYLLRRMKSDVKMSLSLP
DKNEQV--LFCRLTDEQHKVYQ--NFVDSKEVYRILNGEMQIFSGLIALRKICNHPD

ENSGT00590000083118_2_Linker_0_1 (898, 935)

LFS
GGPKNLKGLPDDELE-EDQFGYWKRSGKMIVVES

PF00271 // ENSGT00590000083118_2_Domain_1 (935, 1040)

LLKIWHKQGQRVLLFSQSRQMLDILE
VFLRAQKYTYLKMDGTTTIASRQPLITRYNEDTSIFVFLLTTRVGGLGVNLTGANRVVIY
DPDWNPSTDTQARERAWRIGQKKQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVLKDPKQ
RRFFKSNDLYELFTLTSPDASQSTETSAIF----------------------------AG
TGSDVQTPKCHLKRKIQPAFGAD--HDV---------PKHKKFPASNISINDAT-SS---
---EEKSEAKGAEVNVVPSNQ--SDPLK-DDPHMSSNIASN-DRLGEET----NAVSG--
-PEESSVISGNGECSNSSGTGKTSRPSGDESI-DEKLGLSYKRERPSQAQTESFWENKQM
ENNFYKHKSKTKHHSVAEEETLEKHLRPKQKPKNPKHCRDAKFEGTRIPHLVKKRRYQKQ
DGENKSEAKEQSNDDYVLEKLFKKS-VGVHSVMKHDAIMDGASPDYVL---VEAEANRVA
QDALKALRLSRQRCLGAVSGVPTWTGHRGISGAPAGTK--SRFGKKRNSNFSVQHSSLTS
PTEKCQDGIMKKE---GKDNVPEHFSGRAEDADSSSGALASSSLLAKMRARNHLILPERL
ESESGHLQEA--SALL-PTTEHDDLLVEMRNFIAFQAHTDGQASTREILQEFESKLSASQ
SCVFRELLRNLCTFHRTSGGEGIWKLKPEYC

MYKQPSTPGFCSPLATESLSAQRREDAEDSLYKMPNEEISHSTQTQEQDCL-----QRQH
ISTNEESSTEQKND-G--D-AEKKEHLPSPF---SDFGPSTSTEGCTSAAARRGPALLHI
DRHQIPAVEPSAQALELQGLGVDVYDQAVLEQGVLQQVDSAILEANRVAQLVDAEKEYRS
VLDDLMSCTTSLRQINKIIEQLSPQAATNRDINRKLDSVKRQKYNKEQQLKKITAKQKRL
QAILGGLEVR--VELDHASLEE-EDEEPG----PSCLGSMLMPAQETAWEELIRTGQMTP
FGTQVPQKQEKKPRKIMLNEASGFEKYLADQA--KLSFERKKQ-AANKRAARKAPALVMS
KAGPGP----HENKTNQRNKVLSKTDKCLKKRIRKLQKRAL--QFQGKVGLPRGKKPLES
EARPKS-EGDSESGESWSCLTEQEE----------EAEAGLCGDATDYELRPVLKGRKRQ
KKAS---VQEVDDDFFPSSGEEAEAN------GGGKGSRKVVRCQDDGDEDYYKQRLRRW
NKLRLQDKE-KRLKLEDDSEESDAEFDEGFKVPGFLFKKLFKYQQTGVRW

PF00176 // ENSGT00590000083118_2_Domain_0 (591, 898)

LWELHCQQAG
GILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRFEGLGPTILVCPTTVMHQWVKEFHT
WWPPFRVAVLHETGSYSHKKEKLIRDIAHCHGILITSYSYIRLMQDDISKHDWHYVILDE
GHKIRNPNAAVTLACK-----QFRTPHRI---IL--SGSPMQNNLRELWSLFDFVFPGKL
GTLPVFMEQFSVPITMGGYSNASPVQVKTAYKCACVLRDTINPYLLRRMKSDVKMSLSLP
DKNEQV--LFCRLTDEQQKVYQ--NFIDSKEVYRILNGEMQIFSGLIALRKICNHPD

ENSGT00590000083118_2_Linker_0_1 (898, 935)

LFS
GGPKNLRGLPDDELE-ENQFGYWKRSGKMIVVES

PF00271 // ENSGT00590000083118_2_Domain_1 (935, 1040)

LLKIWQKQGQRVLLFSQSRQMLHILE
VFLRSQKYSYLKMDGSTTIASRQPLITKYNEDTSIFVFLLTTRVGGIGVNLTGANRVIIY
DPDWNPSTDTQARERAWRIGQKKQVTVYRLLMAGTIEEKIYHRQIFKQFLTNRVLKDPKQ
RRFFKSNDLYELFTLTSPDASQSTETSAIF----------------------------AG
TGSDVRTPKCHLKKKIPSAFGTD--SGI---------PNCRKFPDSDTSINDEE-KSKR-
NLTEEKSKATETEGNTETSAE--SNPLK-SNPHRNGNVTSS-DRLEEET----KAVSG--
-REEPIVISGNRDRSDSASIGGKSQPSGEEST-DEKQSPSYKGES-SQVQSERLRKNEQI
ESHFCKHKSKTKHHNVSEEEISEKHLQQQPKVKNSKHCKDAKFEGIRVPHLVKKRQYHKR
DTERASEAQERSSDDYVLEKLFKKS-VGVHSVVKHDAIIDGASPDYVL---VEAEANRVA
QDALKALRLSRQRCLGAMSGIPTWTGHRGTSGAPAGIK--SRFGQKKNSNLSVQRPS-TS
PTDKCQDGVMKKE---GKDHGLDHFSGKAEDSESSSGALASSSLLARMRARNHLILPERL
ESESGHLPEA--SAPQALTTEHDDLLVEMRNFIAFQAHIDGQASTQEILQEFESKLSASQ
SCVFRELLRNLCTFHRTPQGEGIWKLKPEYC

---------------------------------MPYEEIPNSPQPQDQDCS-----PSQH
VSANEDMPVGQESG-G--D-SETGECISTSF----EYGPSTSAEACVLAATRRGPSLLHI
DRHQIPAVEPSAQALELQGLGVDVYDQAVLEQGVLQQVDSAMHEASRVAQFADAEKEYQS
VLDDLMSCTTSLRQINKIIEQLSPQAATNRDINRKLDSVKRQKCNKEQQLKKITAKQRRL
QAILGGAEVQ--IELDHANLEE-EDAEPG----PSCLGSMLMPAQEATWEELIRTGQMTP
FGTPAPQKQEKKPRKIMLNEVSGFEKYLADQA--QLSFERKKR-TANKRAAKKAV--VVS
ESCAEP----NETKPGQRSQGLSQADKRLKKHIRKLQKRAL--QFQGKVGLSRGKKPLEP
EVRPEA-EGDTEGEVSGEEEE--EEQEEEKE---EEGVANLSSDDVTYELRPLRKGRKYQ
KKVP---VQDVDDDFFPSSGEEDEAME------GRGGGRKVARCPDDGDEAYYKQRLRRW
NKLRLQDKE-KRLKLEDDSEESDAEFDEGFKVPGFLFKKLFKYQQTGVRW

PF00176 // ENSGT00590000083118_2_Domain_0 (591, 898)

LWELHCQQAG
GILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRFEGLGPTIIVCPTTVMHQWVKEFHM
WWPPFRVAILHETGSYAHKKERLVRDIVHCHGVLITSYSYIRLMQDDISRHDWHYVILDE
GHKIRNPNAAVTLACK-----QFRTPHRI---IL--SGSPMQNNLRELWSLFDFIFPGKL
GTLPVFMEQFSVPITMGGYSNASPVQVKTAYKCACVLRDTINPYLLRRMKSDVKMSLSLP
DKNEQV--LFCRLTDEQHKVYQ--NFIDSKEVYRILNGENQIFSGLVALRKICNHPD

ENSGT00590000083118_2_Linker_0_1 (898, 935)

LFS
GGPKNLSGLPEDELE-EDQFGYWKRSGKMIVVES

PF00271 // ENSGT00590000083118_2_Domain_1 (935, 1040)

LLKIWHKQGQRVLLFSQSRQMLHILE
VFLRAHKYSYLKMDGTTTIASRQPLITKYNEDTSIFVFLLTTRVGGIGVNLTGANRVIIY
DPDWNPSTDTQARERAWRIGQKKQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVLKDPKQ
RRFFKSNDLYELFTLSSPDASQSTETSAIF----------------------------AG
TGSDVQTPKCHFKKKTPPALGTD--------------PKCKKFPFSDTSANGAI-LT---
---EEESKATGAAG-SATSRE--GGPLK-DDCHPSGSRANS-VAFGEET----GTGSK--
-LEQVSVISGDGKYSDVPTVDQTSGPSCEAST-SEKQGPSYKGEC-CQVQTEPVCVSEQT
DGHFCKHKSKRKH-GVTKEETPEKHPQPKQKAKTSKHCRDAKFEGTRVPYLVKKRRYHQQ
NSEQESKAKERSSDDYVLEKLFKKS-VGVHSVVKHDAIMDGTNPDYVL---VEAEATRVA
QDALKALKFSRQQCLGAASGVPTWTGHRGISGAPAGIK--NRFGKKRNSNLPVQRSSS-S
LTEKHQNN-VKKE---GKAPAPEHFSGKEDGV-SLSGAPSSSSLLARMRARNHLILPERL
ETDSGHLAEA--AALPPCSTEHDDLLVEMRNFIAFQAQVDGQASTQEILQEFESKLSVAQ
SCVFRELLRNLCNFHRTPGGEGIWKLKPEYC

---------------------------------MFHEEVPNSTHPQEQDCL-----PSQH
ANAYKDMPVGQENG-G--V-SEARECLSSTS---CEYGPSTSAEACVLAATRRGPTLLHI
DRHQIPAVEPSAQALELQGLGVDVYDQAVLEQGVLQQVDSAMHEASCVAQLADAEKEYQS
VLDDLMSCTTSLRQINKIIEQLSPQAASNRDINRKLDSVKRQKYNKEQQLKKITAKQKRL
QAILGGAGVQ--VELDHASLEE-DDAEPG----PSCLGSMLMPAQETTWEELIRTGQMTP
FGTPAPQKQEKKPRKIMLNEASGFEKYLAEQA--QLSFERKKQ-AVTKRTAKKAV--VIS
ESSRAA----NETKADQRSQVLSQTDKRLKKHSRKLQRRAL--QFQGKVGLLSGKKPLEP
EVRPEA-EGDTEGEESGSSSTDGEEEEEQEE---EEGVASLSSDDVSYELKPIRKRQKYQ
KKVP---VQEIDDDFFPSSEEEDEAME------GRGGGRKVARRQDDGDEDYYKQRLRRW
NRLRLQDKE-KRLKLEDDSEESDAEFDEGFKVPGFLFKKLFKYQQTGVRW

PF00176 // ENSGT00590000083118_2_Domain_0 (591, 898)

LWELHCQQAG
GILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRFEGLGPTIIVCPTTVMHQWVKEFHT
WWPPFRVAVLHETGSYAHKKERLIRDIVYCHGVLITSYSYIRLMQDDISRHDWHYVILDE
GHKIRNPNAAVTLACK-----QFRTPHRI---IL--SGSPMQNNLRELWSLFDFIFPGKL
GTLPVFMEQFSVPITMGGYSNASPVQVKTAYKCACVLRDTINPYLLRRMKSDVKMSLSLP
DKNEQV--LFCRLTDEQHKVYQ--NFIDSKAVYRILNGENQIFSGLVALRKICNHPD

ENSGT00590000083118_2_Linker_0_1 (898, 935)

LFS
GGPKNASGPPEDELE-EEQFGHWRRSGKMIVVES

PF00271 // ENSGT00590000083118_2_Domain_1 (935, 1040)

LLKIWHRQGQRVLLFSQSRQMLHILE
VFLRAHKYSYLKMDGTTTIASRQPLITKYNEDTSIFVFLLTTRVGGLGVNLTGANRVIIY
DPDWNPSTDTQARERAWRIGQKKQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVLKDPKQ
RRFFKSNDLYELFTLTSPDASQGTETSAIF----------------------------AG
TGSSIQTPKCHLKKRTSTVLGTD--------------PKCKKPPVSDTPANAAT-LI---
---GEKPKAAGATGRSVTSGE--SSPFK-GDHDTDGNRASS-VAFGEET----DAGST--
-LEHLSVMSGDGKHSDSPAVDHTSRPPVEAST-SEKQGSSYTGAR-CQAQTEPGRMSEQM
EGQFSKYKSKRKH-DASEEETTEKRPQPKQKAKNSKHCRDAKFEGTRVPHLVKKRRYRQQ
TGEQEGGAKDRSSDDYVLEKLFKKS-VGVHSVVRHDAIIDGSSPDYVL---VEAEANRVA
QDALKALRLSRQQCLGAASGVPTWTGHRGISGAPTGVK--NRFGQKRNSSLPVQHPWS--
LTERTQNN-MKKE---GKAHTPEHFSGKEDGA-SVSGAPSSSSLLARMRARNHMILPERL
ESDSEHLAEA--AAVPPCGTEHDDLLVDMRNFIAFQAQVDGQASTQEILQEFESKLSMAQ
SCVFRELLRNLCNFHRTPGGEGIWKLKPEYC

---------------------------------MPTEDNHLADGIQEQDTGT--TVSNNH
LHNAEESGTKQENGMCN---SELGNSSGVHE---SPSQPSTS-MAGPLEVPRRGQPLLHI
NRQQIQSVSCSAQAAELKGLGVDVYDQDVLEQGVLQQVDNAINEASKAAKIADAEKEYQL
VLDDLRSCTSSLKQINKIIEQLSPQAANNKDINRKLDSVKRQKYNKEQQLKKINAKQKRL
QAILGGTEIL-DK-ISEIEF-EDD-EEPG----PSSLGSMLMPVQETEWEELIRTGQMTP
FGTKIPQKPERKARRLMLNEASDFEKYLADQA--KLSSERKKL-SLHKGAKKKAQAKNVQ
CIAPTS----TTKEKKGK--SLSKTDKRLKKHLKKLQRHAL--QIQPKSGIPKEK-YPET
K-KLKR-EQEDDSGDSEYVPDEELFDPEEVEEE-EEWVPSHANNDSDYELKNFSRKGKHL
VKRDSK-EAEEDADYFPSSEEE--EPT--------VGKRKVKRWRDDGDEDYYKQRLRRW
QKERLKDKE-HQ-VAEEGSDESDTEFEEGFKVPGFLFKKLFK

PF00176 // ENSGT00590000083118_2_Domain_0 (583, 899)

YQQTGVRWLWELHCQQAG
GILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRYQGLGPTVIVCPATVMHQWVKEFHT
WWPPFRVAILHETGSYTNKKVKLIREIASCHGILITSYSYIRLMQDNIHSYDWHYVILDE
GHKIRNPNAAVTLACK-----QFRTPHRI---IL--SGSPMQNNLKELWSLFDFIFPGKL
GTLPVFMEQFSVPITMGGYSNASPVQVKTAYKCACVLRDTINPYLLRRMKADVKMSLSLP
DKNEQV--LFCRLTDEQRQVYQ--NFIDSKEVYQILSGDMQVFPGLVALRKICNHPDL

ENSGT00590000083118_2_Linker_0_1 (899, 962)

FS
GGPRILKGVPDAEVEEADQFGFWKRSGKMIVVESLLKIWHKQGHRVLFFTQSRQMLQILE
A

PF00271 // ENSGT00590000083118_2_Domain_1 (962, 1040)

FVRDRSYSYLRMDGTTTIASRQPLITRYNEDKSIFIFLLTTRVGGIGVNLTGADRVIIY
DPDWNPSTDTQARERAWRIGQKKQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVLKDPKQ
RRFFKSNDLYELFTLSSPDVSQGTETSAIF----------------------------AG
TGSDVQVPKHQLKRKHEKPSDG-DTSKGGLHLGRSSSPKYSKSSNSYSTSHMTNS-S---
---KAIETSEETKGNLETFNQ--NSYAK-DNAQAATNINSL--NKNKEESLETDDKCMSQ
SLPGDTGSSENANSLNIMVTDEIHGAANVNV--EGDLTLACSAAG-SWEKQVAKTEDGQL
DNNHYKCTSKTKHKV-----DVLSHESHKDKSK-KKHHKDAKFEGERIPHLVKQKRYRKE
DSEEK-EEDPKKNDDYVLEKLFKK-S-GVHSVMKHDAIIEASNADYVL---VEAEANRVA
QDALRALKVSRQRCLGAASGVPTWTGTSGLSGAPAGTKFRSRFGQKRNLMLLSSRSTCVS
PGRKNKDADTIKKENVKSSSSSTHFDGKSETGESSSSALESSSLLAKMRARNHLILPQRT
ESEGDENLHE-APTPAAVSTEYDELLVDVRNFIAFQARVDGEASTQEILQEFDSKLPAAQ
SCVFRELLRNLCTFHRSPNGEGVWRLKPEFR

---------------------------------MPTHKSLLPDSAQEQESAT--TSSNDC
LHNDENSGTEQENGICD---NGVGNSVGIPN---SDCQASTS-MAVPLEAPRRTHPLLQI
NRQQIQSVSCSAHAAELKDLGVDVYDQDVLEQGVLQQVDNAINEANKAAKIANASKEYES
VLEDLRSCTTSLRHINKIIEELSPQAADNKNVNRKLDSVKRQKYNKEQQLKKIKAKQKRL
QGILGLTEFA--DEAN--EIEYEEDEEPG----PSSLGSMLMPAQETEWAELIRTGQMTP
FGTKIPQKPERKARQLRLNEASDFEKYLADQA--KLSSERRKL-SRHRGAKKKAQAKNVQ
CVAPAA----ATKEKSGK--ALSKTDKRLKKHLRELQKHAL--QIHSKARIPKEKKYPEA
K-KFRH-EQEDDSGESEYVPDEELFDPEAAEEE--EQSSSLDENDSDYELKSLSRKRKHL
VKKGFK-EDENDADFVPSSEEE--EHT--------PGKHKVRRWRDDGDVDYYKQRLRKW
QKERLKDKE-HQ-TAEELSEESDVEFEEGFKVPGFLFKKLFK

PF00176 // ENSGT00590000083118_2_Domain_0 (583, 897)

YQQTGVRWLWELHCQQAG
GILGDEMGLGKTIQIIAFLAGLSYSNMRTRGSNYRYQGLGPTVIVCPATVLHQWVKEFHT
WWPPFRVAVLHETGSYTKSKVKLIHEIASCHGILITSYSYIRLMQDNIHTYDWHYVILDE
GHKIRNPNAAVTLACK-----QFRTPHRI---IL--SGSPMQNNLKELWSLFDFIFPGKL
GTLPVFMEQFSVPITMGGYCNASPVQVKTAYKCACVLRDTINPYLLRRMKADVKMSLSLP
DKNEQV--LFCRLTEEQRQIYQ--NYINSKEVYQILNGDMQILLGLSTLRKICNHP

ENSGT00590000083118_2_Linker_0_1 (897, 963)

DFVA
DSPRILKSVPDAEVEDPNQFGYWKRSGKMIVVESLLKIWHKQGHRVLFFTQSRQMMQILE
VF

PF00271 // ENSGT00590000083118_2_Domain_1 (963, 1040)

VRYRNYSYLRMDGTTAVASRQPLVTKYNEDKSIFLFLLTTRVGGIGVNLVGADRVIIY
DPDWNPSVDTQARERAWRIGQKKEVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVLKDPKQ
NRFFKSNDLYELFTLNSPDVSQGTETSAIF----------------------------AG
TGSDVQVPKPPDK--------------RDIHIAENSSHKKIKSSNSYSTTHMKDSSF---
---KAIETNEETKGNLEAFNQ--NSYAK-DNAQAATDTNSL--NKSKEECLEDDDKCLSQ
SMPCSAGSSENAERLTAVVAGEGHGAAPADA--RTDLSPTSDTTG-SWEKQGAKTEDGQF
DNNHSKCISKTKHKV-----DMLSHDSHKDKSK-KKHHKDAKFEGKRIPHLVKQKQFRRE
NSEE---QDSKKNDDYVLQKLFKKSG--VHSVMKHDAIMDASNADHVL---EEAEASRVA
QDALRALRLSRQQCLGAASGVPTWTGTSGLSGAPSGIK--SRFGQKRNSMLLSSHSTCAS
PAKKHKDGDTIKKQNIKKCSSSEHFNGKS--GESSSSALDSSSLLARMRARNHLVLPQQT
RSEGDENHQP-APAPVQGSTEYDELLVDLRNFLAFQARVDGEASTRELLQEFESKLPAEH
SCVFRELLRNICTFHRSPSGEGVWRLKPEFR

---------------------------------MSHEGIPKSSQIQEHDRV-----QSQH
VGTNGDVSVEQENS-G--D-PEVEKRLPSPS---SDCGPST-AEACLSAPTRRGSALLHI
DRHQIPSVEPCAQALELQGLGVDVYDQAVLEQGVLQQVDGAMHEASRAAQLADAEKEYLS
VLDDLTSCTTSLRQINKIIEQLSPQAATNRDINRKLDSVKRQKYNKEQQLKKITAKQKRL
QAVLGGAEVL--VELDHAGLQE-VDAEPG----PSCLGSMLMPAQESAWEELIRTGQMTP
FGTQIPQKQEKKPRRIMLNEESGFEKYLAEQA--QLSFEKKKQ-AASKRAARKAL--APS
-----------ASKASQRHCGLSQTDQRLKKHIRRLQRRAL--QFQGKVGLPRGRRPPEP
QARSEA-EGDSEGEESGSFPTEGEEEEQE-E---EDEEADLSSEGTDYDLKPLRKGRRRQ
QKAP---AQEVDDDFLPSSGEEAEAA-------GGGGGRKGARCRDDGDEEYYRQRLRRW
NKQRLQDRE-NSLKLEDESEESDAEFDEGFKVPGFLFKKLFKYQQTGVRW

PF00176 // ENSGT00590000083118_2_Domain_0 (591, 898)

LWELHCQQAG
GILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRFLGLGPTVIVCPTTVMHQWVKEFHT
WWPPFRVAVLHETGSYAHKKEKLIRDIVHCCGILITSYSYIRLMQDDMSKHDWHYVILDE
GHKIRNPNAAVTLACK-----QFRTPHRI---IL--SGSPMQNNLRELWSLFDFIFPGKL
GTLPVFMEQFSVPITMGGYSNASPVQVKTAYKCACVLRDTINPYLLRRMKSDVKMSLSLP
DKNEQV--LFCRLTDEQHKVYQ--NFIDSKEVYGILNGENQIFSGLVALRKICNHPD

ENSGT00590000083118_2_Linker_0_1 (898, 935)

LFS
GGPKNLSGLPDDEQE-EDQFGYWKRSGKMIVVES

PF00271 // ENSGT00590000083118_2_Domain_1 (935, 1040)

LLKIWHKQGQRVLLFSQSRQMLHILE
VFLRAQKYSYLKMDGTTTIASRQPLIAKYNEDASIFVFLLTTRVGGIGVNLTGANRVIIY
DPDWNPSTDTQARERAWRIGQKKQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVLKDPKQ
RRFFKSNDLYELFTLTSPDASQSTETSAIF----------------------------AG
TGSDVQTPKRHSKRKTQPAPGVD--CDL---------PKCKKLSDSDTSARDTM-LT---
---EEKPETTGAEGDRGPSKE--SSPLK-DDHMSG--NETGIVGLGNKT----NATSE--
-PEQLPVINENGKCSDSPGVSITPKLSGKTSV-PEKQGPSYKGEC-CQVQTQPLWASGQM
EGHSYKHKSKTKH-GVPKEETPEKHLWPKQTPRTSRHCKDARFEGTRVPHLVKKRRYRKQ
EAEQEGEAKQRSSDDYVLEKLFKKS-VGVHSVVKHDAIVDGASPDYVL---VEAEASRVA
QDALKALRLSRQQCLGAASGVPTWTGQRGISGAPAGLK--SRFGQKRNSSLPTQRLSSSS
PTEKCQDA-VKKK---EKDQDPEHFSGKAEGAESSSGAPTSSSLLARMRARNHLILPERL
ESDRGHLPVP--SSAPPSSTEHDDLLVEMRNFIAFQAQVDGQASTQEILQEFESKLSASQ
SCVFRELLRNLCTFHRT-GGEGIWKLKPEYC

---------------------------------MPNEGIPHSSQTQEQDYL-----QSQP
VSNNEEMAIKQESG-G--D-GAVEEYLPFSS---VGDGLSTSAEGCAAAAPRRGPALLHI
NRHQIQAVEPSAQALELQGLGVDVYDQDVLEQGVLRQVDNAIHEASRTSQLADVEKEYRS
VLDDLTSCTTSLRQINKIIEQLSPQAATSRDVNRKLDSVKRQKYNKEQQLKKISAKQKHL
QAILGGAEVK--IELDHASLE--EDAEPG----PSSLGSMLMPVQETAWEELIRTGQMTP
FGTQIPQKQEKKPRKIMLNEASGFEKYLADQA--KLSFERKKQATCNKRPARKAPASVTP
-PAPTQ----SKNKPNKKAKVLSKKEERLKKHIKKLQKRAL--QFQGKVGLPKARRPWES
DMRPEA-EGDSEGEESEYFPTEEEE--EEEDDEVEGVEADLSGDGTDYELKPLPKGRKRQ
KKVP---VQEVDDDFFPSSGEEAEASPIGEG---GGGGRKVGRYRDDGDEDYYKQRLRRW
NKLRLQDKE-KHLKLEDDSEESDAEFDEGFKVPGFLFKKLFK

PF00176 // ENSGT00590000083118_2_Domain_0 (583, 897)

YQQTGVRWLWELHCQQAG
GILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRFEGLGPTVIVCPTTVMHQWVKEFHT
WWPPFRVAILHETGSYTHKKEKLIRDVAHCHGILITSYSYIRLMQDDISRYDWHYVILDE
GHKIRNPNAAVTLACK-----QFRTPHRI---IL--SGSPMQNNLRELWSLFDFIFPGKL
GTLPVFMEQFSVPITMGGYSNASPVQVKTAYKCACVLRDTINPYLLRRMKSDVKMSLSLP
DKNEQV--LFCRLTDEQHKVYQ--NFVDSKEVYRILNGEMQIFSGLIALRKICNHP

ENSGT00590000083118_2_Linker_0_1 (897, 962)

DLFS
GGPKNLKGLPDDELE-EDQFGYWKRSGKMIVVESLLKIWHKQGQRVLLFSQSRQMLDILE
V

PF00271 // ENSGT00590000083118_2_Domain_1 (962, 1040)

FLRAQKYTYLKMDGTTTIASRQPLITRYNEDTSIFVFLLTTRVGGLGVNLTGANRVVIY
DPDWNPSTDTQARERAWRIGQKKQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVLKDPKQ
RRFFKSNDLYELFTLTSPDASQSTETSAIF----------------------------AG
TGSDVQTPKCHLKRKIQPAFGAD--HDV---------PKRKKFPASNISINDAT-SS---
---EEKSEAKGAEVNVVPSNQ--SDPLK-DDPHMSSNIASN-DRLGEET----NAVSG--
-PEESSVISGNGECSNSSGTGKTSRPSGDESI-DEKLDLSYKRKRPSQAQTESFWENKQM
ENNFYKHKSKTKHHSVAEEETLEKHLRPKQKPKNPKHCRDAKFEGTRIPHLVKKRRYQKQ
DSENKSEAKEQSNDDYVLEKLFKKS-VGVHSVMKHDAIMDGASPDYVL---VEAEANRVA
QDALKALRLSRQRCLGAVSGVPTWTGHRGISGAPAGTK--SRFGKKRNSNFSVQHSSSTS
PTEKCQDGIMKKE---GKDNVPEHFSGRAEDANSSSGALASSSLLAKMRARNHLILPERL
ESESGHLQEA--SALL-PTTEHDDLLVEMRNFIAFQAHTDGQASTREILQEFESKLSASQ
SCVFRELLRNLCTFHRTSGGEGIWKLKPEYC

---------------------------------MPHDEVPNSPQPQEQDCS-----LSQH
ASANEDMLVGQESG-G--D-SEAGECLSASC----EYGPSTSAEACVLAATRRGPALLHI
DRHQIPSVEPSAQALELQGLGVDVYDQAILEQGVLQQVDSAMHEASRGAQFADAEKDYQS
VLDDLMSCTTSLRQINKIIEQLSPQAATNRDVNRKLDSVKRQKYNKEQQLKKITAKQKRL
QAILGGAGVQ--VELDQASLEE-EDTEAG----PSCLGSMLMPAQEAAWEELIRTGQMTP
FGTPAPQKPEKKPRKIMLNEVSGFEKYLADQA--QLSFERKKR-TANKKAARKAV--VIA
ESSAGP----NETKPDQSRQVLSQADKRLKKHMRKLQKRAL--QFQGKVGLPWGKKGLEP
AVRPEA-EGDTEGEESGSFPTDGEEEEEQEE---EEAVANLSSDDISYELKPLRKGRKYQ
KKVP---VHEVDDDFFPSSGEEDEAME------GRGGGRKVARCRDDGDEDYYKQRLRRW
NKLRLQDKE-KRLKLEEDSEESDAEFDEGFKVPGFLFKKLFKYQQTGVRW

PF00176 // ENSGT00590000083118_2_Domain_0 (591, 898)

LWELHCQQAG
GILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRFEGLGPTLIVCPTTVMHQWVKEFHT
WWPPFRVAILHETGSYAHKKEKLIRDIVHCHGVLITSYSYIRLMQDDISRHDWHYVILDE
GHKIRNPNAAVTLACK-----QFRTPHRI---IL--SGSPMQNNLRELWSLFDFIFPGKL
GTLPVFMEQFSVPITMGGYSNASPVQVKTAYKCACVLRDTINPYLLRRMKSDVKMSLSLP
DKNEQV--LFCRLTDEQHKVYQ--NFIDSKEVYRILNGENQIFSGLVALRKICNHPD

ENSGT00590000083118_2_Linker_0_1 (898, 935)

LFS
GGPKNLSGLPEDELE-EDQFGYWKRSGKMIVVES

PF00271 // ENSGT00590000083118_2_Domain_1 (935, 1040)

LLKIWHKQGQRVLLFSQSRQMLHILE
VFLRAHKYSYLKMDGTTTIASRQPLITRYNEDTSIFVFLLTTRVGGIGVNLTGANRVIIY
DPDWNPSTDTQARERAWRIGQKKQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVLKDPKQ
RRFFKSNDLYELFTLSSPDASQSTETSAIF----------------------------AG
TGSDVQTPKCHLKNKTPPAPGTN--------------AKCKKLPISDTSANGAL-LT---
---EEKSEAMGSAG-SAPSTE--SGPVQ-GDCLPSGSGTSS-VAFGEET----GAGST--
-LEQLSAMSEDGKRSDCPVVYQTSGPSGEASA-SEKQGPSSKGEC-CQVQTGPALVSEQT
EGHFCKHKSKRKH-DAAKEETPEKC-LPKQKAKNSKHCRDAKFEGTRVPHLVKKRRYRQQ
NPEQEGAAKERSSDDYVLEKLFKKS-VGVHSVVKHDAIMDGTNPDYVL---VEAEASRVA
QDALKALKFSRQQCLGAASGVPTWTGHRGSSGAPAGMK--NRFGKKRNSNLPVQRPSS-S
LTEKSQNN-VKRE---GKAPAPKHFSGKEDGA-SLSGAPSSSALLARMRARNHLILPERL
ESDNGHLPEA--TTLPPSSTEHDDLLVEMRNFIAFQAQVDGQASTQEILQEFESKLSAAQ
SCVFRELLRNLCSFHRTPGGEGIWKLKPEYC

---------------------------------MPREEIPHSPQPQEQDCS-----PSHH
VSAIEDMPVGQESG-G--D-AEAGECLSTSC----ESGPSTSAEACLLAATRRGAPLLHI
DRHQIPAVEPSAQALELQGLGVDVYDQAVLEQGVLQQVDSAMHEASRVAQVADAEKEYQS
VLDDLMSCTTSLRQINKIIEQLSPQAATNRDVNRKLDSVKRQKYNKEQQLKKITAKQKRL
QAILGGAGAQ--VELDPASLEE-EDAEPG----PSCLGSMLMPAQEAAWEELIRTGQMTP
FGTPAPQKQEKKPRKIMLNEVSGFEKYLADQA--QLSFERKKR-GANRRVARKNM--VVS
ESSAGP----NETKPDQRNQGLCQADKRLKKHIRRLQKRAL--QFQGKVGLPRGKKPLEP
AVRLEA-EEDTEGEQSGSFPSDGEEEE-QEE---EEEVANLSSDDISYELKPLRKGQKRQ
KKTP---VREVDDDFVPSSGEEDEALE------ARGGGRKVARCPDDGNEDYYKQRLRRW
NQLRLQEKE-QRPKLDDDSEESDAEFDEGFRVPGFLFKKLFKYQQTGVRW

PF00176 // ENSGT00590000083118_2_Domain_0 (591, 898)

LWELHCQQAG
GILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRFEGLGPTMIVCPTTVMHQWVKEFHT
WWPPFRVAILHETGSYAHKKEMLIRDIVRCHGVLITSYSYIRLMQDDISRHDWHYVILDE
GHKIRNPNAAVTLACK-----QFRTPHRI---IL--SGSPMQNNLRELWSLFDFIFPGKL
GTLPVFMEQFSVPITMGGYSNASPVQVKTAYKCACVLRDTINPYLLRRMKSDVKMSLSLP
DKNEQV--LFCRLTDEQHTVYQ--NFIDSKEVYGILNGENQIFSGLVALRKICNHPD

ENSGT00590000083118_2_Linker_0_1 (898, 935)

LFS
GGPKNLSGLPEDELE-EDQFGYWKRSGKMIVVES

PF00271 // ENSGT00590000083118_2_Domain_1 (935, 1040)

LLKIWHKQGQRVLLFSQSRQMLHILE
VFLRAHKYSYLKMDGTTTIASRQPLITKYNEDTSIFVFLLTTRVGGIGVNLTGANRVIIY
DPDWNPSTDTQARERAWRIGQKKQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVLKDPKQ
RRFFKSNDLYELFTLSSPDASQSTETSAIF----------------------------AG
TGSDVQTPKCHLKKKTPPAPETG--------------PKCKKVSVSDTSANGAI-LT---
---QEKSKSMGAVE-SATCRA--SGPLK-SDCHPSVSRTSSVVAVGEKT----GAGSE--
-LEQLSVMSGDGKCSDFPTVDQTSGPSGEAST-SEKQGPSYKGEC-CQVQPEPVCRSERM
EGRFYKHKSKRKH-DAAKEETPEKCLQSKQKSKHAKHCRDAKFEGTRVPHLVKKRRYHQQ
NSEQASEAEERSSDDYVLEKLFKKS-VGVHSVVKHDAIMDGANPDYVL---VEAEASRVA
QDALKALKFSRQQCLGAASGVPTWTGHRGVSGAPAGMK--NRFGKKRNSNLPVQRPSS--
QTEKCQNT-VKKE---GKASAPEHFSGREDGT-SLSGAPSSSSLLARMRARNHLILPERL
ESNSGHLAEA--AALLPSSTEHDDLLVEMRNFIAFQAQVDGQASTQEILQEFESKLSAEQ
SCVFRELLRNLCNFHRTPGGEGIWKLKPEYC

---------------------------------MPNERIPHSSQTQEPDCS-----QSQD
VSGSEEGTVKQEKD-G--D-VDLGPSLPSCS---SADGPSSSTEGCLLELPRRGPALPHI
DRHQIQAVEPSAQALELQGLGVDVYDQDVLEQGVLQQVDSAIHEASRVAQLAEAEKEYRS
VLDDLTSCTTSLRQIGRIIEQLGPQAATNKDVSRKLDSVKRQKYNKEQQLKKITAKQKRL
QAVLGGAEVK--VELGPGSLEE-EDAGAE----PSCLGSMLMPAQETAWEELVRTGQMTP
FGTKIPQKQEKKPRKLMLNEASGFEKYLADQA--KLSFERKKQ-ACNKRAAKKALASATS
ELSSTL----NENKPDERGKVVSKTDKRLKKHIKKLQKRAL--QLQGQVGLLKGKKPWDC
DVRPQA-QGASEGEESEYLPTEEELE--------EAVGADLPGEGADWEQRLVLNRRKRQ
KKVT---VREIDDDFFPSSGEEAEG-------T--GGGRKVVRCRDDGDEDYYKQRLRRW
NKLRLKDRE-KSPRLEDDSEESDAEFDEGFKMPGFLFKKLFKYQQTGVRW

PF00176 // ENSGT00590000083118_2_Domain_0 (591, 898)

LWELHCQQAG
GILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRFEGLGPTIIVCPTTVMHQWVKEFHT
WWPPFRVAVLHETGSFTHKKERLVRDIAHCHGILITSYSYIRLMQDDISRHDWHYVILDE
GHKIRNPNAAITLACK-----QFRTPHRI---IL--SGSPMQNNLRELWSLFDFIFPGKL
GTLPVFMEQFSVPITMGGYSNASPVQVKTAYKCACVLRDTINPYLLRRMKSDVKMSLSLP
DKNEQV--LFCRLTDEQHKVYQ--NFIDSKEVYRILNGEMQIFSGLVALRKICNHPD

ENSGT00590000083118_2_Linker_0_1 (898, 935)

LFS
GGPKSLKGAPDEELG-EDEFGYWKRSGKMIVVES

PF00271 // ENSGT00590000083118_2_Domain_1 (935, 1040)

LLKIWHKQGQRVLLFSQSRQMLDILE
VFLRAQKYSYLKMDGTTAIASRQPLIARYNEDTSVFVFLLTTRVGGLGVNLTGANRVIIY
DPDWNPSTDTQARERAWRIGQKKQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVLKDPKQ
RRFFKSNDLYELFTLSSPDTSQSTETSAIF----------------------------AG
TGSDVQTPRRHLKRRLQQACGTD--PNV---------PVGRQFPDGKTSANAAV-SS---
---EERPAAPGSEVRAGTSDQ--GIPLK-DALQTPHSLTSS-ERLGEEA----DAVSR--
-PRESLVIHENGDSSGSPRIGRTCGTSGEEST-NEKESLSDKRES-CQVQREPLWENEQT
ENNCYKHKSKMKH-HVAEE-AREKHLRSNQKPESSKHRRDAKFEGTRIPHLVKKRQYRRR
DSENESEAKERSHDDYVLEKLFRKS-VGVHSVMRHDAIVDGASPDCVL---VEAEASRVA
QDALRALRLSRQRCLGAASGVPTWTGHRGLAGAPAGKK--SRFGQKRNSSFSVQRPSSTS
PKEKCQDSTVKKD---GKDHVLEHFSGKVEDAESSSGALTSSSLLAKMRARNHLILPERL
ESEIGRLPEA--AAPLPGSTEHDELLVEMRNFIAFQAQVDGQASTQEILQEFESKLSASQ
SCVFRELLRNLCTFHRTSAGEGIWKLKPEYC

---------------------------------MPNEGIPHSSQTQEQDCL-----QSQP
VSNNEEMAIKQESG-G--G-GEVEEYLSFRS---VGDGLSISAVGCASAAPRRGPALLHI
DRHQIQAVEPSAQALELQGLGVDVYDQDVLEQGVLQQVDNAIHEASRASQLADVEKEYRS
VLDDLTSCTTSLRQINKIIEQLSPQAATSRDINRKLDSVKRQKYNKEQQLKKITAKQKHL
QAILGGAEVK--IELDHASLE--EDAEPG----PSSLGSMLMPVQETAWEELIRTGQMTP
FGTQIPQKQEKKPRKIMLNEASGFEKYLADQA--KLSFERKKQ-ACNKRAARKTPAPVTP
-PAPVQ----N--KPNKKARVLSKKEERLKKHIKKLQKRAL--QFQGKVGLPKARRPWES
DMMPEA-EGDSEGEGSEYFPTEEEE--EEEDDEVEGAEADLSGDGTDYELKPLPKGGKRQ
KKVP---VQEIDDDFFPSSGEEAEAASVGEG---GGGGRKVGRYRDDGDEDYYKQRLRRW
NKLRLQDKE-KCLKLEDDSEESDAEFDEGFKVPGFLFKKLFKYQQTGVRW

PF00176 // ENSGT00590000083118_2_Domain_0 (591, 898)

LWELHCQQAG
GILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRFEGLGPTVIVCPTTVMHQWVKEFHT
WWPPFRVAILHETGSYTHKKEKLIRDVAHCHGILITSYSYIRLMQDDISRYDWHYVILDE
GHKIRNPNAAVTLACK-----QFRTPHRI---IL--SGSPMQNNLRELWSLFDFIFPGKL
GTLPVFMEQFSVPITMGGYSNASPVQVKTAYKCACVLRDTINPYLLRRMKSDVKMSLSLP
DKNEQV--LFCRLTDEQHKVYQ--NFVDSKEVYRILNGEMQIFSGLIALRKICNHPD

ENSGT00590000083118_2_Linker_0_1 (898, 935)

LFS
GGPKNLKGLPDDELE-EDQFGYWKRSGKMIVVES

PF00271 // ENSGT00590000083118_2_Domain_1 (935, 1040)

LLKIWHKQGQRVLLFSQSRQMLDILE
VFLRAQKYTYLKMDGTTTIASRQPLITRYNEDTSIFVFLLTTRVGGLGVNLTGANRVVIY
DPDWNPSTDTQARERAWRIGQKKQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVLKDPKQ
RRFFKSNDLYELFTLTSPDASQSTETSAIF----------------------------AG
TGSDVQTPKCHLKRRIQPAFGAD--HDV---------PKRKKFPASNMSVNDAT-SS---
---EEKSEAKGAEVNAVTSNR--SDPLK-DDPHMSSNVTSN-DRLGEET----NAVSG--
-PEELSVISGNGECSNSSGTGKTSRPSGDESI-DEKLGLSYKREGPSQAQTEAFWENKQM
ENNFYKHKSKTKHHSVAEEETLEKHLRPKQKPKNSKHCRDAKFEGTRIPHLVKKRRYQKQ
DSENKREAKEQSNDDYVLEKLFKKS-VGVHSVMKHDAIMDGASPDYVL---VEAEANRVA
QDALKALRLSRQRCLGAVSGVPTWTGHRGISGAPAGKK--SRFGKKRNSNFSVQHPSSTS
PTEKCQDGIMKKE---GKDNVPEHFSGRAEDADSSSGALASSSLLAKMRARNHLILPERL
ESESGHLQEA--SALL-PTTEHDDLLVEMRNFIAFQAHTDGQASTREILQEFESKLSASQ
SCVFRELLRNLCTFHRTSGGEGIWKLKPEYC

---------------------------------MSDGGLAHSSPTLERDCL-----QNEH
VQKDGGAAVREKDSGETEVDLGVEGRLPSCS---SIEGPSTSAEGSVPNAARRGPALLHI
DRHQIQAVEPSAQAVELQGLGVDVYDQDVLEQGVLQQVDSAIHKASHAAQLADAEKEYGS
VLDDLASCTTSLXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXX
XXXXXXXXXX--XXXXXXXXXXXXXXXPG----PSSLGSMLMPAQESAWEELIRTGQMTP
FGTQIQPKPEKQPRKIMLDEASGFEKYLAEQA--KLSFERRKR-VRGKRAARQAPTPVTA
VSGPAA----SEGKPS-RGATLSKADRRLQKHMRKLQKRAA--QFQGKVVPRPRRKPLEA
EVQPRA-AGHSEGEESEYIPTEEEDEEEE-DEEEAAAGVDLSGDGTDYELKPLPCGRRRQ
KKAA---AQQVDEDFFPSSEEDVDAPA-----AGPGRGRKATRCRDDGDESYYRQRLRRW
NKLRLQDRK-ERAQAEADSEESDAEFDEGFRVPGFLFKKLFK

PF00176 // ENSGT00590000083118_2_Domain_0 (583, 899)

YQQTGVRWLWELHCQQAG
GILGDEMGLGKTIQIIAFLASLSYSKIRTRGSNYRFEGLGPALIVCPTTVMHQWVKEFHT
WWPPFRVAILHETGSYTHKKRNIIRDNAHWQGIQITSYSYLRLMQDDISRHKLPYLILDE
GHKIRNTNAAVTLRK------QFRTPHRI---IL--SGSPMQNNLRELWSLFDFIFPGKL
GTLPVFMEQFSVPITMGGYSNASPVQVKTAYKCACVLRDTINPYLLRRMKSDVKMSLSLP
DKNEQV--LFCRLTDEQHKVYQ--NFIDSKEVYAILNGEMQIFSGLIALRKICNHPDL

ENSGT00590000083118_2_Linker_0_1 (899, 962)

FS
GGPKNCSSLPYDGLE-EEQFGYWKRSGKMIVVESLLKIWHKQGQRVLLFSQSRQMLHILE
A

PF00271 // ENSGT00590000083118_2_Domain_1 (962, 1040)

FLRARKYSYLKMDGTTTVASRQPLITQFNEDASIFVFLLTTRVGGLGVNLTGANRVIIY
DPDWNPSTDTQARERAWRIGQKKQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVLKDPKQ
RRFFKSNDLYELFTLSSPDAAQSTETSAIF----------------------------AG
TGSDVQTPRRPLKRKSRPALGTD--QDA---------PKCRTFLRPSPLPEGAA-LP---
---AEKPAGTGAEVHTVASDE--GGSAK-GHPHTSASITPCGDRMAEEG----LVASG--
-PEDSEVGSGSGKHQNALGTARPSGLCAEGSG-DTKSDLSSKTKG---SQAELLWENERP
ETVFSKHKSKTKHQTGAAEETPEQHETPKPKPKAHRPHRDAKFEGTRISHLVKQRRYHQQ
DGGDTDEAAHRSTDDYVLEKLFRKS-GGVHSVMRHDAIMDGASHDYVL---VEAEANRVA
QDALKALRLSRQRCLGAGSGVPTWTGHRGSSGAPAGVR--SRFGQKRNSHLPVQR-----
AVEKCQDGVTVPE---GKDRGSGHFSGHGEEVESSSCA---SSSVAKMRARNLLIAPERL
ESEDRHVPGA--AAPAPSATEHDELLVEVRNFVAFQARVDGQASTQEILREFESRLSASQ
SCVFRELLRNLCTFHRTPGGEGIWKLKPQYC

---------------------------------MPSEGSLHSCQTQDQERS-----QSPP
VRADEDTAV--EQERG--GAVEAGEHVASPP---SNYMPSTSAEGCTSAAMRRGLALLHI
DRHQIPAVEQNAQALELQGLGVDVYDQSVLEQGVLQQVDSALNEAGRAAQLADAEKEYRC
VLDDLTSCTTSLRQINKIIEQLSPQAATNRDINRKLDSVKRQKYNKEQQLKKITAKQKRL
QAVLVGAEVR--VELEH-GGLEEEDAEPG----PSCLGSMLMPAQETAWEELIRTGQMTP
FGTRVPQKTEKKPRKLMLNEASGFEKYLADQA--KLSFERKKQ-AANKRASRKAPPSVKS
ESSAQS----KEKKPKQRSKVLSKTDWRLKKHIRKLQKRAL--QFQGKVGLPRGKRPLEA
EARLQ-TK----------------------------------GDEEDCELRPVLRGQKRQ
KKVP---PWKSDDNFSPSSGEEAEA--TE---GGGGTGRKVVRCCDDGDEDYYKQRLRRW
KKL-----E-KHLKLEDDSEESDAEFDEGFKVPGFLFKKLFKYQQTGVRW

PF00176 // ENSGT00590000083118_2_Domain_0 (591, 898)

LWELHCQQAG
GILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRFEGLGPTLIVCPTTVMHQWVKEFHT
WWPPFRVAILHETGSCTNRKAKLIRDIAHCHGILITSYSYIRLMQDDISRHDWHYVILDE
GHKIRNPNAAVTVACK-----QFRTPHRI---IL--SGSPMQNNLRELWSLFDFVFPGKL
GTLPVFMEQFSVPITMGGYANASPVQVKTAYKCACVLRDTINPYLLRRMKSDVKMSLSLP
DKNEQV--LFCRLTDEQHKVYQ--NFIDSKEVYKILNGEMQIFSGLVALRKICNHPD

ENSGT00590000083118_2_Linker_0_1 (898, 935)

LFS
GGPKNLGRLPEDELE-EDQFGYWKRSGKMIVVES

PF00271 // ENSGT00590000083118_2_Domain_1 (935, 1040)

LLKIWHKQGQRVLLFSQSRQMLHILE
VFLRAQKYSYLKMDGSTTIASRQPLIARYNEDASIFVFLLTTRVGGIGINLTGANRVIIY
DPDWNPSTDMQARERAWRIGQKRQVTVYRLLMAGTIEEKIYHRQIFKQFLTNRVLKDPKQ
RRFFKSNDLYELFTLTSPDGSQSTETSAIF----------------------------AG
TGSDVPTPKRHFKRKIPPAFGTD--QNV---------PKYRKFPDSDTFANVAT-SS---
---EDKSKATGAEGSMVTSST--SGPLK-SDPHPGSRVTSS-DRVSEET----GAVSG--
-PEEPPMTGRNEYCSSSPQIDRAPGLSGEESI-AVKQGPSGEGDR-GQVPAELPQENGQV
RSHSCKHKSKTKHQDVAEEGALEK----KQKPQGAKHRRDAKFEGTRVPHLVKRRRYHRH
DEGPESKPKAHSGDDYVLEKLFKKS-VGVHSVVKHDAIVDGASPDYVL---VEAEANRVA
QDALKALRLSRQQCLGATSGVPTWTGHSGA-----RVK--SRFGQKRNSNLSVQRPLLS-
TTKQFQDGVVKRE---EKDRTSEHFSGKAEDMDSSSAALTSSSLLARMRARNHLILPEHL
ESENGHPAEV--SALPLCATEHDELLVDMRNFIAFQARVDGQASTRELLQEFEPKLSTSQ
SCVFRELLRNLCMFHRTSSGEGVWRLRPEYC

---------------------------------MPNEGIPHSSQTQEQDCL-----QSQP
VSNNEEMAIKQESS-G--D-GEMEEYLRSHS---MGDGLFTSAEGCASAAPRRGPALLHI
DRHQIQAVEPSAQALELQGLGVDVYDQDVLEQGVLQQVDNAIHEASCASQLADAEKEYRS
VLDDLTSCTTSLRQIDKIIEQLSPQAATSRDINRKLDSVKRQKYNKEQQLKKITAKQKRL
QAVLGGAEVK--VELDHTSLEE-EDAEPG----PSSLGSMLMPVQETAWEELIRTGQMTP
FGTQIPQKQEKKPRKIMLNEASGFEKYLADQA--KLSFERKKQ-ACNKRAARKAPAPVMS
-PAPMQ----NKNKPNKKTKVLSKKEERLKKHIKKLQKRAL--QFQGKVGLPKTRRPWES
DMRPQA-EGDSGGEESEYFPTEEEEE-EEEDDEVEGMEADLSGDGTDYELKPLPKGRKRQ
KKVP---VQEIDDDFFPSSGEEAEASPVGGGV---GGGRKVGRHRDDGDEDYYKQRLRRW
NKLRLQDKE-KRLKLEDDSEESDAEFDEGFKVPGFLFKKLFKYQQTGVRW

PF00176 // ENSGT00590000083118_2_Domain_0 (591, 898)

LWELHCQQAG
GILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRFEGLGPTVIVCPTTVMHQWVKEFHT
WWPPFRVAILHETGSCTHKKEKLIRDVVHCHGILITSYSYIRLMQDDISRYDWHYVILDE
GHKIRNPNAAVTLACK-----QFRTPHRI---IL--SGSPMQNNLRELWSLFDFIFPGKL
GTLPVFLEQFSVPITMGGYSNASPVQVKTAYKCACVLRDTINPYLLRRMKSDVKMSLSLP
DKNEQV--LFCRLTDEQHKVYQ--NFIDSKEVYRILNGEMQIFSGLIALRKICNHPD

ENSGT00590000083118_2_Linker_0_1 (898, 935)

LFS
GGPKNLKGLPDNELE-EDQFGYWKRSGKMIVVES

PF00271 // ENSGT00590000083118_2_Domain_1 (935, 1040)

LLKIWHKQGQRVLLFSQSRQMLDILE
VFLRAQKYTYLKMDGTTTIASRQPLITRYNEDTSIFVFLLTTRVGGLGVNLTGANRVVIY
DPDWNPSTDTQARERAWRIGQKKQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVLKDPKQ
RRFFKSNDLYELFTLTSPDASQSTETSAIF----------------------------AG
TGSDVQSPKCHLKRKIQPAFGAD--HDI---------PKHKKFPASNIPINDAT-SS---
---EEKPKVKGGEVNAVTSSQ--SDPLK-DDPHMSSNVTSN-DRLGEET----NAVSG--
-PEESSVISGNGECSNSSRTDKTSRLSGDESI-DEKFGLSYKREIPSQAQTESFWENKQT
ENKFYKHKSKTKHHNAAEEKILEKHLRPKQKSKNPKHCRDAKFEGTRIPHLVKKRRYQKQ
DTENKSEAKEQSNDDYVLEKLFKKS-VGVHSVLKHDAIMDGASPDFVL---VEAEANRVA
QDALKALRLSRQRCLGAVSGVPTWTGHRGISGAPAGTK--SRFGKKRNSNFSVQHPSLKS
PAEKCQDGVMKKE---GKDNVPGHFSGRAEDAESSSGALASSSLLAKMRARNHLILPERL
ESESGHLQEA--SAPL-PTTEHDDLLVEMRNFIAFQAHTDGQASTREILQEFESKLSASQ
SCVFRELLRNLCTFHRTSGGEGIWKLKPEYC

---------------------------------MPNERIPYSSQTQEQDCL-----QSQH
VNNNEEMATKQEIG-G--D-ARVEECLPSRS---PDDGPSASAEGCASAAPRRAQALLHI
DRHQIQAVEPSAQAPELQGLGVDVYDQDVLEQCVLQQVDNAIHEASRVAQLADAEKEYQS
VMDDLTSCMTSLRQINKIIEQLSPQAATNRDVNRKLDSVKRQKYNKEQQLKKITAKQKRL
QAILGGAEVK--VELDHASLEE-EDAEAG----PSCLGSMLMPVQETAWEELIRTGQMTP
FGTQIPQKQEKKPRKIMLNEESGFEKYLADQA--KLSFERKKQ-ASNKRAARKAPTSVTP
ELNPTQ----TDNKPNKKTKVLSKTDKRLKKHIKKLQKRAL--QFQGKVGLPRGKKPWES
DVRPKA-EGDSESEESEYFPTEEE-----GDDEADWAEADLSRDGTDYELRPVLKGQKRQ
KKVS---VQEIDDDFFPSSGEEAEA--TGG----GGAGWKVARCRDDGDEDYYKQRLRRW
NKLRLQDKE-KRLKLEDDSEESDAEFDEGFKVPGFLFKKLFKYQQTGVRW

PF00176 // ENSGT00590000083118_2_Domain_0 (591, 898)

LWELHCQQAG
GILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRFEGLGPTVIVCPTTVMHQWVKEFHT
WWPPFRVAILHEAGSCTHKKEKLIRDIAHCHGILITSYSYIRLMQDDMSRYDWHYVILDE
GHKIRNPNAAVTLACK-----QFRTPHRV---IL--SGSPMQNNLRELWSLFDFVFPGKL
GTLPVFMEQFSVPITMGGYSNASPVQVKTAYKCACVLRDTINPYLLRRMKSDVKMSLSLP
DKNEQV--LFCRLTDEQHKVYQ--NFVDSKEVYRILNGEMQIFSGLIALRKICNHPD

ENSGT00590000083118_2_Linker_0_1 (898, 935)

LFS
GGTKNLKGLPEDELE-EDQFGYWKRSGKMIVVES

PF00271 // ENSGT00590000083118_2_Domain_1 (935, 1040)

LLKIWHKQGQRVLLFSQSRQMLHILE
VFLRAQRYSYLKMDGTTTIASRQPLIARYNEDRSIFVFLLTTRVGGLGVNLTGANRVIIY
DPDWNPSTDTQARERAWRIGQKRQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVLKDPKQ
RRFFKSNDLYELFTLTSPDASQSTETSAIF----------------------------AG
TDSDVQTPKRHLKRKIQTAFGTD--HDA---------PKCKKFPDSSTSANDAT-SS---
---EKKSEAVGAKVIALTSDQ--GDLLK-GDPHMSSTVTSS-SRPGEET----GAVST--
-PEKSPVVSGDGGCSHSSGIGSMSRPSGEEST-DEKQGLSDERES-CQGQTEPLWENEQM
ENNFCKHKSKTKHQNVAEAETLEKHVRPKQKPRNSKHRRDARFEGTRIPHLVKKRQYQKQ
DEENRSEAKEQSNDDYVLEKLFKKS-VGVHSVMKHDAIMDGASPDYVL---VEAEANRVA
QDALKALRLSRQRCLGAGSGVPTWTGHRGSSGAPAGLK--SRFGQKRNSKFSVQHPSSAS
PAEKFQGGAAKQE---GKGHVPEHFSGRAEDAEPSSGALPSSSLLATMRARNHLILPARL
ESESGHLQEA--PAPM-LTTEHDALLVEMRNFIAFQAHVDGQASTREILQEFESKLSVSQ
SCVFRELLRNLCTFHRTSGGEGIWKLKPEYC

---------------------------------MPSEGSRHSCQTQEQEHS-----QSPP
VRADEDTTG--EQEHG--GAVEVGKQLASPP---SDCGPSTSAEGCTSAAMRRGPTLVHI
DRHQIPAVERNAQALELQGLGVDVYDQTVLEQGVLQQVDSALHEASRAAQLADAEKEYQS
VLDDLMSCMTSLRQINKIIEQLSPQAATNRDINRKLDSVKRQKYNKEQQLKKITVKQKRL
QAVLGRAEVR--VELEHAGGLEEEDAEPG----PSCLGIMLMPAQKTAWEELIRTGQMTP
FGTQVLQKTEKKPRKLMLNEASGFEKYLADQA--RLSFERKKQ-AANKRTSRKAAASVKP
ASNAQS----KENKPKQRSQILSKTDWRLKKHIRKLQKKAL--QFQGKVGLPRGKRSLGA
EARLQ-AMGNSESEEPRSFPMEG-----EEEGDGEEVGADLSGDGADCELRPELRGQKRQ
KKVP---AQENDDDFSPSSGEEAEA--TE---RGRGTGRKVVRCCDDGDEDYYKQRLRRW
TKLRLQNKE-KHLKLEDDSEESDAEFDEGFKVPGFLFKKLFKYQQTGVRW

PF00176 // ENSGT00590000083118_2_Domain_0 (591, 898)

LWELHCQQAG
GILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRFEGLGPTIIVCPTTVMHQWVKEFHT
WWPSFRVAILHETGSCTHRKENLIRDIAHCHGILITSYSYIRLMQDDFSRQNWHYVILDE
GHKIRNPNAAVTLACK-----QFRTPHRI---IL--SGSPMQNNLRELWSLFDFVFPGKL
GTLPVFMEQFSVPITMGGYANASPVQVKTAYKCACVLRDTINPYLLRRMKSDVKMSLSLP
DKNEQV--LFCRLTDEQHKVYQ--NFINSKEVYKILNGEMQLFSGIVALRKICNHPD

ENSGT00590000083118_2_Linker_0_1 (898, 935)

LFS
GGPKNLGGLPDDELE-EDQFGYWKRSGKMIVVES

PF00271 // ENSGT00590000083118_2_Domain_1 (935, 1040)

LLKIWHKQGQRVLLFSQSRQMLHILE
VFLRAQKYSYLKMDGTTTIASRQPLIARYNEDASIFVFLLTTRVGGIGVNLTGANRVIIY
DPDWNPSTDTQARERAWRIGQKRQVTVYRLLMAGTIEEKIYHRQIFKQFLTNRVLKDPKP
RRFFKSNDLYELFTLTSPNGSQSTETSAIF----------------------------AG
IGSDVPTPKRHLKRKILPAFGTD--RDV---------PKCKKFPDSNTLANVAT-SS---
---EHKSKATRAEGIMVTSSP--SNRLK-TDPHPGGRVTSS-DRVSEGT----SAASG--
-PEEPPVTSGNGDCSDCPRIGGALLLSGEENI-AAKQGPSDEGDS-GLVPAEPPRENEQV
GSHSYKHKSKRKHQGVAEEGTLEK----RQKHESTRHRRDAKFEGTRVPHLVKRRRYHRH
DLGPDSKARVHSGDDYVLEKLFKKS-VGVHSVVKHDAIMDGASPDYVL---VEAEANRVA
QDALKALRLSRQQCLGAASGVPTWTGHRGA-----RVK--SRFGQKRNSNLSVHRPSSS-
STEECQDGLVKRE---GKDHMSEHFSGKAEDTDSSSGALTSSSLLARMRARNHLILPERL
ESENGHVAEV--SAPPSCATEHDELLVDMRNFIAFQARVDGQASTRELLQEFEPKLSASQ
SCVFRELLRNLCTFHRTPGGEGVWRLRPEYC

---------------------------------MPNKGIPHSSQTQEQDYL-----QSQP
VSNNEEMAIKQESG-G--D-GEVEEYLPFSS---VGDGPSTSAEGCASAASRRGPVLLHI
NRHQIQAVEPSAQALELQGLGVDVYDQDVLEQGVLRQVDNAIHEASRTSQLADVEKEYRS
VLDDLTSCTTSLRQINKIIEQLSPQAATSRDINRKLDSVKRQKYNKEQQLKKITAKQKHL
QAILGGAEVK--IELDHASLE--EDAEPG----PSSLGSMLMPVQETAWEELIRTGQMTP
FGTQIPQKQEKKPRKIMLNEASGFEKYLADQA--KLSFERKKQATCNKRPARKAPASVTP
-PAPTQ----SKNKPNKKAKVLSKKEERLKKHIKKLQKRAL--QFQGKVGLPKARRPWES
DMRPEA-EGDSEGEESEYFPTEEEEEEEEEDDEVEGVEADLSGDGTDYELKPLPKGRKRQ
KKVP---VQEIDDDFFPSSGEEAEASPIGEG---GGGGRKVGRYRDDGDEDYYKQRLRRW
NKLRLQDKE-KRLKLEDDSEESDAEFDEGFKVPGFLFKKLFKYQQTGVRW

PF00176 // ENSGT00590000083118_2_Domain_0 (591, 898)

LWELHCQQAG
GILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRFEGLGPTVIVCPTTVMHQWVKEFHT
WWPPFRVAILHETGSYTHKKEKLIRDVAHCHGILITSYSYIRLMQDDISRYDWHYVILDE
GHKIRNPNAAVTLACK-----QFRTPHRI---IL--SGSPMQNNLRELWSLFDFIFPGKL
GTLPVFMEQFSVPITMGGYSNASPVQVKTAYKCACVLRDTINPYLLRRMKSDVKMSLSLP
DKNEQV--LFCRLTDEQHKVYQ--NFVDSKEVYRILNGEMQIFSGLIALRKICNHPD

ENSGT00590000083118_2_Linker_0_1 (898, 935)

LFS
GGPKNLKGLPDDELE-EDQFGYWKRSGKMIVVES

PF00271 // ENSGT00590000083118_2_Domain_1 (935, 1040)

LLKIWHKQGQRVLLFSQSRQMLDILE
VFLRAQKYTYLKMDGTTTIASRQPLITRYNEDTSIFVFLLTTRVGGLGVNLTGANRVVIY
DPDWNPSTDTQARERAWRIGQKKQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVLKDPKQ
RRFFKSNDLYELFTLTSPDASQSTETSAIF----------------------------AG
TGSDVQTPKCHLKRKIQPAFGAD--HDV---------PKRKKFPASNISINDAT-SS---
---EEKSEAKGAEVNVVPSNQ--SDPLK-DDPHMSSNIASN-DRLGEET----NAVSG--
-LEESSVISGNGECSNSSGTGKTSRPSGDESI-DEKLGLSYKRERPSQAQTESFWENKQM
ENNFYKHKSKTKHHSVAEEETLEKHLRPKQKPKNPKHCRDAKFEGTRIPHLVKKRRYQKQ
DSENKSEAKEQSNDDYVLEKLFKKS-VGVHSVMKHDAIMDGASPDYVL---VEAEANRVA
QDALKALRLSRQRCLGAVSGVPTWTGHRGISGAPAGTK--SRFGKKRNSNFSVQHSSSTS
PTEKCQDGIMKKE---GKDNVPEHFSGRAEDADSSSGALASSSLLAKMRARNHLILPERL
ESESGHLQEA--SALL-PTTEHDDLLVEMRNFIAFQAHTDGQASTREILQEFESKLSASQ
SCVFRELLRNLCTFHRTSGGEGIWKLKPEYC

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------EQQLKKITAKQKHL
ETTLGRAEVK--VEIDSVSVEE--DAEPG----PSCLGSMLMPAQETAWEELIRTGQMTP
FGTHIPQKLEKKPRKLMLNEVSGFEKYLADQA--KLSFERKKQ-VCNKRTRRKAQVSATS
ELNLTL----NENKQTQRRKILSKTDKCLKRHIKKLQKRAL--QFQGKVGLLKGKKPLEA
DKKG--EEGAFQSDESDYIPKEEEMEEM--------AESD-LSESVDYELKPLRRRQKQQ
KKVT---AQEIDEQFSPSSEEEIEAAE------GRGGGRKTVRCRDDGDEDYFKQRLRKW
NKLRLQEKE-PSLKLEDSSEDSDAEFDEGFRMPGFLFRRLFK

PF00176 // ENSGT00590000083118_2_Domain_0 (583, 899)

YQQTGVRWLWELHCQQVG
GILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRFQGLGPTIIVCPT-VMHQWVKELHT
WWPPFRVAVLHDTGSCAHKKEKLIGDIAHYHGILITSYSYIRLMQDNISRHDWHYVILDE
GHKIRNPNAAITLACKQ---XXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXX-----X
XXXXXXXXXXXXXXXXXXXXXXXXVQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXX--XXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXIFSGLTTLRKICNHPDL

ENSGT00590000083118_2_Linker_0_1 (899, 962)

FS
GGPRNPGVLPDDELQ-EDQFGYWKRSGKMIVVESLLKIWHKQGQRVLLFSQSRQMLHIFE
V

PF00271 // ENSGT00590000083118_2_Domain_1 (962, 1040)

FLRTQKYSYLKMDGMTTIASRQPLITRYNEDTSIFVFLLTTRVGGIGVNLTGANRVIIY
DPDWNPSTDTQARERAWRIGQKKQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVLKDPKQ
RRFFKSNDLYELFTLTSPDPSQSTETSAIF----------------------------AG
TGSDVQAPKHRFKRKIQAASGVD--HDV---------PKCKKLPGANIAANNAV-SP---
---EEKPKFAGAERHALTSDS--GEPSP-GDSQTSNLLESS-GTLLAEECLKINAVSK--
-LEEPSVIIGNKEFSDYPRISEICRTPGEESS---------------QLQTAPVEENKQM
GNNFYKCKSKTKHHDMVEEKTLEKYQRQKETPKSSKHRKDAKFEGTRIPHLVKKRQYQKQ
E----SEAQERNNDDYVLEKLFKKA-VGVHSVMKHDAIVDGASADYVL---VEAEATRVA
QDALRALRHSRQHCLGAVSGVPTWTGQQGISGVPAVVK--RRFGLKRNSNVSVKNPSLTS
PKEKYQDGAVKN------DHAREHFSGKSEDAASPSVAPTSSSLLTKMRARNHLILPERL
ESENVSLPEI--SSPLLSLTEHDDLLVEMRNFIAFQARVDGQASTQEILQEFESKLSVSQ
SCVFRELLRNLCTFHRTLDGKGIWKLKSEYC

---------------------------------MPNEGIPHSSQTQEQDCL-----QSQP
VSNNEEMAIKQESG-G--D-GEVEEYLSFRS---VGDGLSTSAVGCASAAPRRGPALLHI
DRHQIQAVEPSAQALELQGLGVDVYDQDVLEQGVLQQVDNAIHEASRASQLADMEKEYRS
VLDDLTSCTTSLRQINKIIEQLSPQAATSRDINRKLDSVKRQKYNKEQQLKKITAKRKHL
QAILGGAEVK--IELDHASLE--EDAEPG----PSSLGSMLMPVQETAWEELIRTGQMTP
FGTQIPQKQEKKPRKIMLNEASGFEKYLADQA--KLSFERKKQ-ACNKRAARKAPAPVTP
-PAPVQ----NKNKPNKKARVLSKKEERLKKHIKKLQKRAL--QFQGKVGLPKARRPWES
DMRPEA-EGDSEGEESEYFPTEEEE--EEEDDEVEGAEADLSGDGTDYELKPLPKGGKRQ
KKVP---VQEIDDDFFPSSGEEAEAASVGEG---GGGGRKVGRYRDDGDEDYYKQRLRRW
NKLRLQDKE-KRLKLEDDSEESDAEFDEGFKVPGFLFKKLFKYQQTGVRW

PF00176 // ENSGT00590000083118_2_Domain_0 (591, 898)

LWELHCQQAG
GILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRFEGLGPTVIVCPTTVMHQWVKEFHT
WWPPFRVAILHETGSYTHKKEKLIRDVAHCHGILITSYSYIRLMQDDISRYDWHYVILDE
GHKIRNPNAAVTLACK-----QFRTPHRI---IL--SGSPMQNNLRELWSLFDFIFPGKL
GTLPVFMEQFSVPITMGGYSNASPVQVKTAYKCACVLRDTINPYLLRRMKSDVKMSLSLP
DKNEQV--LFCRLTDEQHKVYQ--NFVDSKEVYRILNGEMQIFSGLIALRKICNHPD

ENSGT00590000083118_2_Linker_0_1 (898, 935)

LFS
GGPKNLKGLPDDELE-EDQFGYWKRSGKMIVVES

PF00271 // ENSGT00590000083118_2_Domain_1 (935, 1040)

LLKIWHKQGQRVLLFSQSRQMLDILE
VFLRAQKYSYLKMDGTTTIASRQPLITRYNEDTSIFVFLLTTRVGGLGVNLTGANRVVIY
DPDWNPSTDTQARERAWRIGQKKQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVLKDPKQ
RRFFKSNDLYELFTLTSPDASQSTETSAIF----------------------------AG
TGSDVQTPKCHLKRRIQPAFGAD--HDV---------PKRKKFPASNISVNDAT-SS---
---EEKSEAKGAEVNAVTSNR--SDPLK-DDPHMSSNVTSS-DRLGEET----NAVSG--
-EEELSVISGNGKCSNSSGTDKTSRPSGDESI-DEKLGLSYKRERPSQAQTEAFWENKQM
ENNFYKHKSKTKHHSVAEEETLEKHLRPKQKPKNSKHCRDARFEGTRIPHLVKKRRYQKQ
DSENKSEAKEQSNDDYVLEKLFKKS-VGVHSVMKHDAIMDGASPDYVL---VEAEANRVA
QDALKALRLSRQRCLGAVSGVPTWTGHRGISGAPAGKK--SRFGKKRNSNFSVRHPSSTS
PTEKCQDGIMKKE---GKDNVPEHFSGRAEDADSSSGALASSSLLAKMRARNHLILPERL
ESESGHLQEA--SALL-PTTEHDDLLVEMRNFIAFQAHTDGQASTREILQEFESKLSASQ
SCVFRELLRNLCTFHRTSGGEGIWKLKPEYC

---------------------------------MSNEKIPYSSPTQEQDCL-----QSQH
VSNNEEMSVNQEIGVG--D-VDVVEEWLRYF---PDDGPSTSAEWYVSEAPKRGQAMLHI
DRRQIQAVEPSVQAPELQGLGVDVYDQEVLEHCVLQQVDSAIHEANRVAQLADAEKEYRS
VLDDLMSCTTSLRQISKIIDQLSPQAATNRDINRKLDSVKRQKYNKEQQLKKIAAKQKRL
QAILGGAEVK--IELDRASLEEEEDAEPG----PSCLGSMLMPVQETAWEELIRTGQMTP
FGTQIPQKQEKKPRKIMLNEASGFEKYLADQA--KLSFERKKQ-ACHKRAARKTPTSVTP
QSKPTQ----NENKPNKKTQVLSKTDKRLKKHIKKLQKRAL--QCQGKMRLPKPKKLWES
DVTPKA-EGDS---ESEYFPTEEEEEQE-EEDEADWAGADLSRDDADYELRPVVKKRKQQ
KKVS---VQEIDDDFFPSSGEESEATV------GEGGGRKVARCRDDGDEDYYKQRLRRW
NKLRLRDKE-KHLKLGEDSEESDAEFDEGFKVPGFLFKKLFK

PF00176 // ENSGT00590000083118_2_Domain_0 (583, 897)

YQQTGVRWLWELHCQQAG
GILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRYEGLGPTIIVCPTTVMHQWVKEFHT
WWPPFRVAILHETGSYTHKKEKLIRDIAHCHGILITSYSYIRLMQDDISRYDWHYVILDE
GHKIRNPNAAVTLACK-----QFRTPHRI---IL--SGSPMQNNLRELWSLFDFVFPGKL
GTLPVFMEQFSVPITMGGYANASPVQVVYRAECK----ENVQAYNFRRLESDVKMSLSLP
DKNEQV--LFCRLTDEQHKIYQ--NFVDSKEVYGILNGEMQIFPGLIALRKICNHP

ENSGT00590000083118_2_Linker_0_1 (897, 962)

DLFS
GGTKNLKGLPEDELE-EDQFGYWKRSGKMIVVESLLKIWHKQGQRVLLFSQSRQMLDILE
V

PF00271 // ENSGT00590000083118_2_Domain_1 (962, 1040)

FLRAQKYTYLKMDGTTTIASRQPLITRYNEDTSIFVFLLTTRVGGLGVNLTGANRVIIY
DPDWNPSTDTQARERAWRIGQKKQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVLKDPKQ
RRFFKSNDLYELFSLTSPDTSQSTETSAIF----------------------------AG
TGSDVQTPKRHLKRRNQPAFGTD--CDV---------PKCEKFPHSHTSANDAP-SS---
---EEKPKSVEAEVNAVTSNQ--GDLLK-DDPHVSSSVTSS-SRLGEEA----NTVSR--
-PEESSATSGNGECSDSLRIGDISRPSGEKSL-DEQQDLSTKRGS-SQVHTEPLCENEQM
ENSFYKHKSKTKHQGMAEEGTLEKHVGQKQKPKNSKHRRDARFEGTRIPHLVKKRRYQKQ
EN-DKSEAKEQSNDDYVLEKLFKKS-VGVHSVMKHDAIMDGASPDYVL---VEAEANRVA
QDALKALRLSRQQCLGAVSGVPTWTGHRGSSGAPAGIK--SRFGQKRNSNFSVQRSSSTS
PTEKYQNGTMKKE---GKDNVLEHFSGRTEDAESSSGALTSSSLLARMRARNHLILPERL
ESEGGHLPEA--SAPL-PTTEHDDLLVEIRNFIAFQAHVDGQASTREILQEFESKLSASQ
SCVFRELLRNLCTFHRTSGGEGIWKLKPEYC

------------------------------------------------------------
---------------------------------------SASAEGGALGAPRRGPALLQI
DRHQIQAVERSAQALELRGLGVDVYDQEVLEQGVLQQVDDAIHEASRAAQLADAEKEYRS
VLDDLTSCTTSLRQINKIIEQLSPQATTSRDINRKLDSVKRQKYNKEQQLKKITAKQKRL
QAILGGAEVN--IEMDLASLEEDAGEEPG----PSCLGSMLMPAQETAWEQLVRTGQMTP
FGTQIPQKQEKKPRRLMLNEASGFEKYLADQA--KLSFERKKQ-ASNKRVRRKARALATS
ELNPTQ----SENKQNERSAVPSKTEKRLKKHIRKLQRRAL--QFQGKVGLLKRAKPVEA
DGQI-G-DGASESEESEDLPEAEEED--------QVAEANLPEGGADYELKPLLKGRKRQ
KKAT---VRELDEDFIPSSGEETEA---------GGAGRKAARWRDDGNEDYYQQRLRRW
NKLRLQDKE-KCLTLEDSSEDSDAEFDEGFKVPGFLFRKLFK

PF00176 // ENSGT00590000083118_2_Domain_0 (583, 899)

YQQTGVRWLWELHCQQAG
GILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYR-QGLGPTVIVCPTTVMHQWVKEFHT
WWPPFRVAILHDTGSYTHKKEKLIRDIARYHGILITSYSYIRLMQDDISRHDWHYVILDE
GHKIRNPNAAITLACK-----QFRTPHRI---IL--SGSPMQNNLRELWSLFDFVFPGKL
GTLPVFMEQFSVPITMGGYSNASPVQVKTAYKCACVLRDTINPYLLRRMKSDVKMSLSLP
DKNEQV--LFCRLTDEQHEVYQ--NFIDSKEVYRILNGEMQIFSGLVALRKICNHPDL

ENSGT00590000083118_2_Linker_0_1 (899, 962)

FS
GGPRHLTGLPDGESE-EDQFGYWKRSGKMIVVESLLKIWHKQGQRVLLFSQSRQMLDILE
V

PF00271 // ENSGT00590000083118_2_Domain_1 (962, 1040)

FLRARKYSYLKMDGTTTIASRQPLITRYNEDTSIFVFLLTTRVGGIGVNLTGANRVIIY
DPDWNPSTDTQARERAWRIGQKKQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVLKDPKQ
RRFFKSNDLYELFTLTSPDPSQSTETSAIF----------------------------AG
TGSDVQTPKRHLKRKMPPAFGID--RDV---------PKCQRFPDSNISANDAT-SP---
---EEKPKSVEAEAHVATSKY--GDPVK-GDPQTGNALTSS-DSLLEEKYLQVDTVPR--
-LEEPLMVSGNRECSDSPRVSKTCGTRAEEST-GEQQGLPRTGES-RQVQTEPLAENGQV
GNHFYKHKSKTKHHDVVEEETLEKSLRREEKPKRSKRCRDAKFEGTRIPHLVKKRQYQKQ
DIANESEVKDRNNDDYVLEKLFKKA-VGVHSVVKHDAIVDGTSADYVL---VEAEAARVA
QDALKALRLSRQRCLGALSGVPTWTGQQGISGAPAGMK--SRFGQKRNSNFPVQHPSSIS
PKEKCQDGAMKKE---KKDKAPEHFSGKAEDADSLSRAPTSSSLLAKMRARNHLILPECL
ESENVPLLEA--SAPPPPTTEHDDLLVEIRNFIAFQARVDGQASTQEILQGFEAKLSASQ
SCVFRELLRNLCTFHRTSGGEGIWKLKPEYC

---------------------------------MPTENSHLPDSIQEQDPIT--TVSSIC
PHNAEESGTEQDNGICN---SDQGNHFGVHS---SDSKPSTS-VAVPMEVPRRGQPLLHI
NRQQIQSVSYSAQAAELKGLGVDVYDQDVLEQGVLQQVDNAINEANKATKIADAEKEYQS
VLDDLRSCTTSLKQIDKIIEQLSPQAANNKDINRKLDSVKRQKYNKEQQLKKIKAKQKRL
QAVLGGTEIL-DK-VNEIEF-EDDEAEPG----PSSLGSMLMPVQETEWEELIRTGQMTP
FGTKIPQKPERKTRRLMLNEASDFEKYLADQA--KLSSERKKL-SLHKRAKKKAQAKNVQ
CVAPTS----ATKERRGK--VLSKTDKRLKKHLKKLQKHAL--QVHSKAGILKEKKNLET
T-KLKP-GQEDDSGESEYVPDEEQLEPAAVEEE-EEQASSHAENDSDYELRNLSRKGKYL
VRRDSK-DAENDADYFPSSEEE--EHT--------VGKRKVKRWRDDGDEDYYKQRLRKW
QRERLKDKE-RP-VAEELSDESDTEFEEGFKVPGFLFKKLFK

PF00176 // ENSGT00590000083118_2_Domain_0 (583, 899)

YQQTGVRWLWELHCQQAG
GILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRYQGLGPTVIVCPATVMHQWVKEFHT
WWPPFRVAILHETGSYTNKKVKLIREIASCHGILITSYSYIRLMQDNIHSYDWHYVILDE
GHKIRNPNAAVTLACK-----QFRTPHRI---IL--SGSPMQNNLKELWSLFDFVFPGKL
GTLPVFMEQFSVPITMGGYSNASPVQVKTAYKCACVLRDAINPYLLRRMKADVKMSLSLP
DKNEQV--LFCRLTDEQRRVYQ--NFIDSKEVYQILNGDMQVFSGLVALRKICNHPDL

ENSGT00590000083118_2_Linker_0_1 (899, 962)

FS
GGPKILKCLPDADLEEADQFGYWKRSGKMIVVESLLKIWHKQGHRVLFFTQSRQMLQILE
V

PF00271 // ENSGT00590000083118_2_Domain_1 (962, 1040)

FVRDRNYSYLRMDGTTTIASRQPLITRYNEDKSIFIFLLTTRVGGIGVNLTGADRVIIY
DPDWNPSTDTQARERAWRIGQKKQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVLKDPKQ
RRFFKSNDLYELFTLSSPDVSQGTETSAIF----------------------------AG
TGSDVQVPKHQLKRKLERPADDDDTLKGGLHLKKSCSPKYSKSSSSHLTSHMANS-S---
---KAIETNKEAKGNLETFDQ--KNYAE-DIAQTATNINSV--NKSKQESLERADISLSQ
SLPGDAEPSENA-----TVTEEEHEVANENA--EGDFSLLCSAAG-CQEKQIGKTEDGQL
DNNHYKCTSKTKHRV-----DMLSHDSHKEKSK-KKHHKDAKFEGERIPHLVKQKRYRKE
DSEEK-ELDPKKNDDYVLEKLFKKTV-GVHSVMKHDAIMEASSADYVL---VEAEANRVA
QDALRALKVSRQRCLGAASGVPTWTGVSGLSGAPSGVKFRSRFGQKRNPMLLSSHSTCAS
PVKKCKDADTMKKENVKKNSTNGHFDGKLETGESSSSVLDSSSLLAKMRARNHLILPQRT
GNEGDENLHQ-APAPAPGSTEYDELLVDVRNFIAFQARVDGEASTQEILQEFESKLPAAQ
SCVFRELLRNLCTFHRNPSGEGVWRLKPEFR

---------------------------------MPNEGIPHSSRTQEQDCL-----QSQD
VSESEEATIKQENG-V--G-VELGESLLS-S---SADGPSCSAEGCPAEVPRRGPALLHI
DRHQIQAVEPSAQALELQGLGVDVYDQDVLEQGVLRQVDSAIQEASRTAQLADAEKEYRS
VLDDLTSCTTSLRQIDKIIEQLSPQAATNRDINRKLDSVKRQKYNKEQQLKKITAKRKRL
QAILGGAEVQ--VEIDHASLEE-EEDAGEDTGNSVFVLDMLMPVQEAAWEELVRTGQMTP
FGTQIPQKQEKKPRKLMLNEASGFEKYLADQA--KLSFERKKQ-ACNKRAARKALASVTS
EPSSTR----SENKPDKKGTVLLKKDKRLEKRIRKLQKKAL--QFQGQVGLPKGKRHLEY
DMRPEA-EGASEGEESEYLPSEEEPQ--------EAAGADLSE----DERRRVLSHRKRQ
KKVT---VQDIDDDFFPSSGEEAEGTG----GG--GGGRKVARCRDDGDEDYYKQRLRRW
NKLRLQDKE-KCLKLEDDSEESDAEFDEGFKMPGFLFKKLFKYQQTGVRW

PF00176 // ENSGT00590000083118_2_Domain_0 (591, 898)

LWELHCQQAG
GILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRFEGLGPTIIVCPTTVMHQWVKEFHT
WWPPFRVAILHETGSFTHKKEKLVRDIAHCHGILITSYSYIRLMQDDISRHDWHYVILDE
GHKIRNPNAAITLACK-----QFRTPHRI---IL--SGSPMQNNLRELWSLFDFIFPGKL
GTLPVFMEQFSVPITMGGYSNASPVQVKTAYKCACVLRDTINPYLLRRMKSDVKMSLSLP
DKNEQV--LFCRLTDEQHKVYQ--NFIDSKEVYRILNGEMQIFSGLVALRKICNHPD

ENSGT00590000083118_2_Linker_0_1 (898, 935)

LFS
GGPKNFKGIPGEELE-EDQFGYWKRSGKMIVVES

PF00271 // ENSGT00590000083118_2_Domain_1 (935, 1040)

LLKIWHKQGQRVLLFSQSRQMLDILE
VFLRAQKYSYLKMDGTTTIASRQPLITRYNEDASIFVFLLTTRVG-----------VIIY
DPDWNPSTDTQARERAWRIGQKKQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVLKDPKQ
RRFFKSNDLYELFTLTSPDTSQSTETSAIF----------------------------AE
ICNVTLTPKRHLKRKFHP--------NV---------AMGKKLPDLNASANDAT-PS---
---EEKSIAMGAEI---------NDPLK-DAPQTPRSLTSS-DRLGGET----DAESR--
-LQESSGIRGNGECSDSTGVGKMCRTPGEDSI-EEEEGLSDKRES-CQVQTEPLWENGQT
DTSFQKHKSKTKH-RVTEEETLEKHLRPKQKPKNSKHRRDAKFEGTRIPHLVKKRQYQRQ
DNENESEVKERSNDDYVLEKLFKKS-VGVHSVMKHDAIMDGASPDYML---VEAEANRVA
QDALKALRLSRQRCLGAASGVPTWTGHRGLAGAPAGRK--SRFGQKRNSNFAVQHPSSAS
PKEKSQDGILKKD---GKDSVSEHFSGKVEDAELSSGALTSSSLLAKMRARNHLILPARL
ESESGHVPEA--SAPLPSSTEHDELLVEMRNFIAFQAQVDGQAGTREILQEFEPRLSASQ
SCVFRELLRNLCTFHRTSGGEGIWKLKPEYC

---------------------------------MPNEGIPHSSQTQEQDCL-----QSQP
VSNNEEMAIKQESG-G--D-GEVEEYLPFCS---VGDGLSTSVVGCASAALRRGPALLHI
DRHQIQAVEPSAQALELQGLGVDVYDQDVLEQGVLQQVDSAIHEASRASQLADVEKEYRS
VLDDLTSCTTSLRQINKIIEQLSPQAATSRDINRKLDSVKRQKYNKEQQLKKITAKQKHL
QAILGGAEVK--IELDHASLE--EDAEPG----PSSLGSMLMPVQETAWEELIRTGQMTP
FGTQIPQKQEKKPRKIMLNEASGFEKYLADQA--KLSFERKKQ-ACNKRAARKAAAPVTP
-PAPVQ----NKNKPNKKARVLSKKEERLKKHIKKLQKRAL--QFQGKVGLPKAGRPWGS
DMRPEA-EGDSEGEESEYFPTEEEE--EEEDDEVEGAEADLSGDGTDYELKPLPKGRKRQ
KKVP---VQEIDDDFFPSSGEEAEASPVG-G---GGGGRKVGRYRDDGDEDYYKQRLRRW
NKLRLQDKE-KHLKLEDDSEESDAEFDEGFKVPGFLFKKLFKYQQTGVRW

PF00176 // ENSGT00590000083118_2_Domain_0 (591, 898)

LWELHCQQAG
GILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRFEGLGPTVIVCPTTVMHQWVKEFHT
WWPPFRVAILHETGSYTHKKEKLIRDVAHCHGILITSYSYIRLMQDDISRYDWHYVILDE
GHKIRNPNAAVTLACK-----QFRTPHRI---IL--SGSPMQNNLRELWSLFDFIFPGKL
GTLPVFMEQFSVPITMGGYSNASPVQVKTAYKCACVLRDTINPYLLRRMKSDVKMSLSLP
DKNEQV--LFCRLTDEQHKVYQ--NFIDSKEVYRILNGEMQIFSGLIALRKICNHPD

ENSGT00590000083118_2_Linker_0_1 (898, 935)

LFS
GGPKNLKGLPDEELE-ADQFGYWKRSGKMIVVES

PF00271 // ENSGT00590000083118_2_Domain_1 (935, 1040)

LLKIWHKQGQRVLLFSQSRQMLDILE
VFLRAQKYTYLKMDGTTTVASRQPLITRYNEDTSIFVFLLTTRVGGLGINLTGANRVVIY
DPDWNPSTDTQARERAWRIGQKKQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVLKDPKQ
RRFFKSNDLYELFTLTSPDASQSTETSAIF----------------------------AG
TGSDVQTPKCHLKRRIQPAFGAA--HDV---------PKCKKFPASNISVNDAT-SS---
---EEKSEAKGAEVNAVTSNQ--SDPLK-DDPHMSSNVTSN-DRLGEET----NAVSG--
-PEESSVISGNGECSNSSATGKTSRPSGDESI-DEKLGLSYKRERPSQAQTESFWENKQM
ENNFYKHKSKTKHHSVAEEETLEKHLRPKQKPKNPKHCRDAKFEGTRIPHLVKKRCYQKQ
DSENKSEAKEQSNDDYVLEKLFKKS-VGVHSVMKHDAIVDGASPDYVL---VEAEANRVA
QDALKALRLSRQRCLGAVSGVPTWTGHRGISGAPAGKK--SRFGKKRNSNFSVQHPSSTS
PTEKCQDGIMKKE---GKDNVPEHFSGRAEDADSSSGALASSSLLAKMRARNHLILPERL
ESESGHLQEA--SALL-PTTEHDDLLVEMRNFIAFQAHTDGQASTREILQEFESKLSASQ
SCVFRELLRNLCTFHRTSGGEGIWKLKPEYC

------------------------------------------------------------
------------------------------------------------MAVRKANTLLQI
DRHQIQAVQSEQQALELQGLGLAVYDQEVLEQGVLQQVDNAINEASRVSRLAEAEQELQQ
LADELRSCVTSLRQINKIIEQLTPQAATCKEIGRKLDSVKRQKHNKEQQLKKIKAKQKRL
KAVLGGSQEEPDIEEDLQGYH-----EEGETTRELCQNFMRFI--SGSFAKIVFYHNIT-
RGLRIKIVLE-GPACKSLHKKSPFLSSWVTQEPQDLPSGRKLLK------NYNPPALITP
FPLPDSLVFQGKGYPGCRIGLGSFGPLQLLHRVMCIL--------NQTLGHQTVVGPWLP
GASRDA-LGLQ-QGNSSYFKMTNQXKKEESMEE-NEEEWVPESQDTEYELKPLIQRTNGK
RP----RENGMDPGFLPSSEEKEDHL---------SRSGKGQRCRDDGNAQLYKQRLRQW
HKQREKEKE-ER-IATEESEDSDVEFDEGFSIPCSIWKKLYK

PF00176 // ENSGT00590000083118_2_Domain_0 (583, 899)

YQQTGVRWLWELHCQQAG
GILGDEMGLGKTIQIIAFLAGLSYSRIRTRGSDYRYEGLGPSIIVCPATVMHQWVKEFHT
WWPQFRVVILHETGSYAGKKVKLIGELGNGCGILITSYSYVRLMQEELQKYHWHYIILDE
GHKIRNPNAGVTLACK-----QFILQHNKVLEDLFGGTAPMQISIFCNWSLFF-LCASYV
RTSPFVEQQKETPI-----SNIPDTKVKTAYKCACVLRDTINPYLLRRMKADVKMSLALP
DKNEQV--LFCRLTDEQRQVYQ--TFIDSKEVYGILNGEMQVFPGLIALRKICNHPDL

ENSGT00590000083118_2_Linker_0_1 (899, 963)

FS
GGPKILKGTRDEDLEEEEQFGFWKRSGKLIVVEALLKIWHRQGHRVLLFTQSRQMLQILE
VF

PF00271 // ENSGT00590000083118_2_Domain_1 (963, 1040)

VRSRCYSYLKMDGTTTIASRQPLIAKYNEDPSLFVFLLTTRVGGLGVNLTGANRVIIY
DPDWNPSTDTQARERAWRIGQKKQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVLKDPKQ
RRFFKSNDLYELFTFSSPDTSHGTETSAIF----------------------------AG
RKSNKNTHSAHLKLSLNQQAYTTK-HSL-----KQRKSNVQEKPDSQTGLKSVI------
---------RGTEHNGIKHFM--SNALKKGGLEMFREATNTNKRIK-------PLNSVLQ
HAQENPMLVGFEARSNSEVTPST-------SI-KLESGKDCKQG----------SLTEAP
ENCHRKHKAKTKHQS---------------KGKSVKRRKDAKYEGERISHLVKQNPFRRE
EGDQH--EDRRKSDDYVLEKLFKKSVFRCSSVAKLNTYLELASTAHAPARSVRTTERRVS
EDR--KMAQSKFACR---IALAGWELSKGGGGGGGEAGNRHRFGQKRNPLLQTPDVPGRL
PQDKCKDLNITKQKDQSSADAPSHFSGENQS--TATAALSSSSLLSRMRARNNMLLPPRD
ENETGT------GVPSAGTTEHDELLADMRNFIAFQARVDGEASTQELLQEFENKLSQKQ
SCVFRELLRRLCTFHRNTDGTGVWRLKPEFH

---------------------------------MPSEGSPHSCSTQEQERL-----QSLP
VRADEETPM--EQEHD--GAAKVGEHLPSPS-LPSDCEPSTSAEGCIPAAVRRGPALLQI
DRHQIPAVEPSAQALELQGLGVDVYDQTVLEQGVLQQVDSALQEASHAAQLADAEKEYQS
VLDDLKSCTTSLRQIDKIIEQLSPQAATNRDINRKLDSVKRQKYNKEQQLKKISAKQKRL
QAILGGAALR--VELDYGSLEEEEAAEPG----PSCLGSMLMPAQETAWEELIRTGQMTP
FGTQVPQKTEKKPRKLMLNEASGFERYLADQE--KLSFERRKQ-AAHKRASRKASASVKS
EPSAGS----KENKPKQRSKGLSNTDRRLKKHIKKLQKRAL--QFQGKVGLPRGKKALEM
EVRPQQAQGDSESEEPGSCPVEW-----EEEGDREEVGASLSGDGADCEQRPVLRGHKHQ
KKGA---VQESDDDFFPSSGEETEA--TE---DQGRTSHKVVRCRDDGDEEYYKQRLRRW
NKLRLRDKE-KRLKLEDDSEESDAEFDEGFKVPGFLFRKLFKYQQTGVRW

PF00176 // ENSGT00590000083118_2_Domain_0 (591, 898)

LWELHCQQAG
GILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRFQGLGPTMIVCPTTVMHQWVKEFHT
WWPPFRVAILHETGSYSHRKEKLIRDIAYCHGILITSYSYVRLMQDDISRQDWHYVILDE
GHKIRNPNAAITLACK-----QFRTPHRI---IL--SGSPMQNNLRELWSLFDFVFPGKL
GTLPVFMEQFSVPITMGGYANASPVQVKTAYKCACVLRDTINPYLLRRMKSDVKMSLSLP
DKNEQV--LFCRLTDEQHKVYQ--NFVDSKEVYKILNGEMQIFSGLVALRKICNHPD

ENSGT00590000083118_2_Linker_0_1 (898, 935)

LFS
GGPKSLGGLPDNELE--DQFGYWKRSGKMIVVES

PF00271 // ENSGT00590000083118_2_Domain_1 (935, 1040)

LLKIWHKQGQRVLLFSQSRQMLHILE
VFLRAQRYSYLKMDGSTTIASRQPLITRYNEDASIFVFLLTTRVGGIGVNLTGANRVIIY
DPDWNPSTDTQARERAWRIGQKRQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVLKDPKQ
RRFFKSNDLYELFTLTSPDPSQSTETSAIF----------------------------AG
TGSDVPTPKQHLKRKILPAFGAD--QDV---------PKCRRFPDSNVLGTVAT-SA---
---EDQSQAVGAEGSTVTCSA--DSPSR-GDPQPVGSETLS-DGVRGET----SVLSG--
-PEEPPVTGRNGPCCGSPGISRVLGPSGEEST-AAKQGPSGDGDG-RQVSAEPPWENAQV
RSHSCKHKSKTKHQGVVEEGAPKK----QQRPEGSKHRRDAKFEGTRVPHLVKRRRFRKH
DADPESEARARSGDDYVLEKLFKKS-VGVHSVVKHDAIMDGASPDYVL---VEAEANRVA
QDALKALRLSRQQCLGATSGVPTWTGHRGT-----GVK--SRFGQKRNSSLSVRCPLS--
SAEKCQDGVVKRE---GRAHTSEHFSGKADDVDSSAVLP-SSSLLARMRARNHLILPERL
ENENGHTPEA--AALPPPTTEHDDLLVEMRNFIAFQARVDGQASTREILQEFESKLSAAQ
SCVFRELLRNLCTFHRTPSGEGVWRLKSEYR

---------------------------------MPNNGTPHSSPAQEQDCP-----QSQC
VGNNEEMVIKQENGGA------AVACPPSCP---SDLGPPTCTEEGGLEAARREPALLRI
DRHQIPAVEPSAQALELQGLGVDVYDQEVLERGVLQQVGDAIHEARRSAQLADAEKEYGS
VLDDLTSCMTSLRQINKIIEQLSPQATINRAVNRKLDSVKRQKYNKEQQLKKITAKQKRL
QAILGGTEVR--VELEHAHLEE--DAEPG----PSCLGSTLMPVQEAAWEELIRTGQMTP
FGTQIPQKQERKPRKLVLDEASGFEKYLADQA--KLSFERKKQ-AGKKRVARKALASATS
--APAQ----KENKQNKGSDSLSKTDKRLKKHIKRLQRRAL--QFQGKVGLPKGKLPFQA
EGRPERGEGDSGSEESEYLPPEEEK-----------EEADLSEDGTDCELRPLPRGGKRQ
KKVP---VQEIGDDFFPSSGEEAEAP-------EGRRGWKIVRCRXXXXXXXXXXXXXKW
DKLRLKDKE-KNLKLEDESEESDAEFDEGFKIPGFLFRKLFK

PF00176 // ENSGT00590000083118_2_Domain_0 (583, 1066)

YQQTGVRWLWELHCQQAG
GILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNY-----GPAIIVCPTTVMHQWVKELHT
WWPPFRVAVLHDTGSYAHRKEKLIREIAHCHGILITSYSYIRLMQDDISRHDWHYVILDE
GHKIRNPNAAITLACK-----QFRTPHRLILIIL--SGSPMQNNLRELWSLFDFVFPGKL
GTLPVFMEQFSVPITMGGYSNASPVQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXX--XXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMLDILE
VFLRAQNYSYLKMDGTTTIASRQPLITRYNEDTSVFVFLLTTRVGGIGVNLTGANRVIIY
DPDWNPSTDTQARERAWRIGQKKQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVLKDPKQ
RRFFKSNDLYELFTLTSPDVSQSTETSAIF----------------------------AG
TGSDVQTPKRHLKRKTQPAFGAD--PDV---------PKCKTMSDPDTSANDVT-SS---
---EDKPKPTGDEVNAVTSNQ--SNALK-DDPQSSSDLTVS-SILVDEKCLQAHAVSR--
-LEGSSMISGNGKCSNSPRISETHAASGEESIIDEKQELSHKRES-CQVLTESISENGHG
ENNCYKHKSKTKHRSVASKETLEKQPTQKQKSKNSTHRRDAKFEGTRIPHLVKKRRYRKP
DNENESEAKEQNNDDYVLEKLFRKS-VGVHSVMKHDVIMDGANPDFVL---VEAEANRVA
QDALKALRLSRQRCLGATSGVPTWTGQQGLSGTSAGIK--SRFGQKRNSNFSVQPPPSTS
PKEKCQGSVVKKE---GRENVPEYFFGKAHYADSSSGAPTSSSLLAKMRARNHLILPERL
ESENAHLPEA--SRPPPATTEHDDLLVEMRNFIAFQAQVDGQASTREILQEFEFKLSASQ
SCVFRELLRNLCTFHRTSSGEGMWKLKPEYC

------------------------------------------------------------
--------------------------------------------------PRRGHPLLQI
NRQQIQSVSCSAHAAELKDLGVDVYDQDVLEQGVLQQVDNAINEATKAAKIANASKEYES
VLEDLSCCLNILCILRTLHLEIFKSYVKSPGIF-KLSKLRVNQFSVGNDCSKH------N
SRIVYIHIFY-TEGVKGMLYVLIFVVEPG----PSSLGSMLMPAQETEWAELIRTGQMTP
FGTKIPQKPERKARQLRLNEASDFEKYLADQA--KLSSERKKL-SRHKGAKKKAQAKSVQ
CVAPAA----ATKEKSGK--ALSKTDKRLKKHLRELQKHAL--QIHSKARIPKEQKYLEA
K-KCRH-EQEDDSGESEYVPDEELFDPEAAEEE-EEQASSFAENDSDYELKSLSRKRKVS
VK-----KAENDADFVPSSEEE--EHT--------PGKHKVRRWRDDGDVDYYKQRLRLW
QKERLKDKE-HQ-TAEELSEESDVEFEEGFKVPGFLFKKLFK

PF00176 // ENSGT00590000083118_2_Domain_0 (583, 897)

YQQTGVRWLWELHCQQAG
GILGDEMGLGKTIQIIAFLAGLSYSNMRTRGSNYR-QGLGPTVIVCPATVLHQWVKEFHT
WWPPFRVAVLHETGSYTKSKVKLIHEIASCHGILITSYSYIRLMQDDIHTYDWHYVILDE
GHKIRNPNAAVTLACK-----QFRTPHRI---IL--SGSPMQNNLKELWSLFDFIFPGKL
GTLPVFMEQFSVPITMGGYCNASPVQVKTAYKCACVLRDTINPYLLRRMKADVKMSLSLP
DKNEQV--LFCRLTEEQRQIYQ--NYINSKEVYQILNGDMQILLGLSTLRKICNHP

ENSGT00590000083118_2_Linker_0_1 (897, 963)

DFVA
DSPRILKSVPDAEAEDPNQFGYWKRSGKMIVVESLLKIWHKQGHRVLFFTQSRQMMQILE
VF

PF00271 // ENSGT00590000083118_2_Domain_1 (963, 1040)

VRYRNYSYLRMDGTTAVASRQPLVTKYNEDKSIFLFLLTTRVGGIGVNLVGADRVIIY
DPDWNPSVDTQARERAWRIGQKKEVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVLKDPKQ
NRFFKSNDLYELFTLNSPDVSQGTETSAIF----------------------------AG
TGSDVQVPKPPAN----------GTSKCDVHVAESSSHK-KKSSNSYSTTHMRDSSS---
---KAIETSGETKGTLEAFDQ--NSYTE-DNAQAAADTSSF--SKSKEECLESDDKCMSQ
SVPHSAGSAANAEGLIA----VGHGATNADV--RTDLSLTCDAAG-SWEKQDAKTEDGQF
DNNHFKCISKTKHKV-----DMLSHESHRDKSK-KKHHKDAKFEGKRIPHLVKQKQYRRE
NSEE---QDSKKNDDYVLQKLFKKSGNRVHSVMKHDAIMDASSADHVL---EEAEASRVA
QDALRALRHSRQQCLGAASGVPTWTGTSGLSGAPSGIK--SRFGQKRNSMLLSSHSTCAS
PAKKHKDGDTIKKQNIRKCSSSEHFNGKS--GESSSSALDSSSLLARMRARNHLVLPQQT
RNEGDENDQP-APAPVQGSTEYDELLVDLRNFLAFQARVDGEASTQELLQEFESKLPAEH
SCVFRELLRNICTFHRSPNGEGVWRLKPEFR

---------------------------------MPYEEIPNSPQPQDQDCS-----PSQH
VSANEDMPVGQESG-G--D-SETGECISTSF----EYGPSTSAEACVLAATRRGPSLLHI
DRHQIPAVEPSAQALELQGLGVDVYDQAVLEQGVLQQVDSAMHEASRVAQFADAEKEYQS
VLDDLMSCTTSLRQINKIIEQLSPQAATNRDINRKLDSVKRQKCNKEQQLKKITAKQRRL
QAILGGAEVQ--IELDHANLEE-EDAEPG----PSCLGSMLMPAQEATWEELIRTGQMTP
FGTPAPQKQEKKPRKIMLNEVSGFEKYLADQA--QLSFERKKR-TANKRAAKKAV--VVS
ESCAEP----NETKPGQRSQGLSQADKRLKKHIRKLQKRAL--QFQGKVGLSRGKKPLEP
EVRPEA-EGDTEGEVSGEEEE--EEQEEEKE---EEGVANLSSDDVTYELRPLRKGRKYQ
KKVP---VQDVDDDFFPSSGEEDEAME------GRGGGRKVARCPDDGDEAYYKQRLRRW
NKLRLQDKE-KRLKLEDDSEESDAEFDEGFKVPGFLFKKLFKYQQTGVRW

PF00176 // ENSGT00590000083118_2_Domain_0 (591, 898)

LWELHCQQAG
GILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRFEGLGPTIIVCPTTVMHQWVKEFHM
WWPPFRVAILHETGSYAHKKERLVRDIVHCHGVLITSYSYIRLMQDDISRHDWHYVILDE
GHKIRNPNAAVTLACK-----QFRTPHRI---IL--SGSPMQNNLRELWSLFDFIFPGKL
GTLPVFMEQFSVPITMGGYSNASPVQVKTAYKCACVLRDTINPYLLRRMKSDVKMSLSLP
DKNEQV--LFCRLTDEQHKVYQ--NFIDSKEVYRILNGENQIFSGLVALRKICNHPD

ENSGT00590000083118_2_Linker_0_1 (898, 935)

LFS
GGPKNLSGLPEDELE-EDQFGYWKRSGKMIVVES

PF00271 // ENSGT00590000083118_2_Domain_1 (935, 1040)

LLKIWHKQGQRVLLFSQSRQMLHILE
VFLRAHKYSYLKMDGTTTIASRQPLITKYNEDTSIFVFLLTTRVGGIGVNLTGANRVIIY
DPDWNPSTDTQARERAWRIGQKKQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVLKDPKQ
RRFFKSNDLYELFTLSSPDASQSTETSAIF----------------------------AG
TGSDVQTPKCHFKKKTPPALGTD--------------PKCKKFPFSDTSANGAI-LT---
---EEESKATGAAG-SATSRE--GGPLK-DDCHPSGSRANS-VAFGEET----GTGSK--
-LEQVSVISGDGKYSDVPTVDQTSGPSCEAST-SEKQGPSYKGEC-CQVQTEPVCVSEQT
DGHFCKHKSKRKH-GVTKEETPEKHPQPKQKAKTSKHCRDAKFEGTRVPYLVKKRRYHQQ
NSEQESKAKERSSDDYVLEKLFKKS-VGVHSVVKHDAIMDGTNPDYVL---VEAEATRVA
QDALKALKFSRQQCLGAASGVPTWTGHRGISGAPAGIK--NRFGKKRNSNLPVQRSSS-S
LTEKHQNN-VKKE---GKAPAPEHFSGKEDGV-SLSGAPSSSSLLARMRARNHLILPERL
ETDSGHLAEA--AALPPCSTEHDDLLVEMRNFIAFQAQVDGQASTQEILQEFESKLSVAQ
SCVFRELLRNLCNFHRTPGGEGIWKLKPEYC

---------------------------------MSNESSPHSSQTQGRDGP-----QSQL
ARNEEEMVIKQENCVV--G---TEACPSSRP---LGPGLLVSAEGAVPAAARRVPALLHI
DRHQIPAVEPGAQALELQGLGVDVYDQEVLEQGVLQQVDSAVHEASRAAQLADAEKEYRA
VLGDLTSCTTSLRQIDKIIEQLSPQATINRDVSRKLDSVKRQKYNKEQQLKKITAKQKRL
QAILGGEEVK--VELEHASLVE-EDAEPG----PSCLGSALMPAQEAAWEELIRTGQMTP
FGTRIPQKQERKPRKLMLNEASGFEKYLADQA--KLSFEKKKQ-TGTKRTTRKAPAPATG
EPGPTL----KENKQK-GSDGLSKTDKRLKKHMKKLQKRAL--QCQGKVGLLKAKRPLEV
EARPKGGDGDSGSEESEYLPHEEEK-----------EEVDLSEDGTDYELRPWIRGGKQQ
KKVP---VREIDDDFFPSSGEETETT-------EGSARRKIARCRDDGDEDYYKQRLRKW
NKLRLQDKE-KRLKLEDDSEESDAEFDEGFKVPGFLFKKLFK

PF00176 // ENSGT00590000083118_2_Domain_0 (583, 897)

YQQTGVRWLWELHCQQAG
GILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRFEGLGPTIIVCPTTVMHQWMKELHT
WWPPFRVAVLHDTGSYSHRKEKLIREIAHCHGILITSYSYIRLKQDDLSRHDWHYVILDE
GHKIRNPNAAVTLACK-----QFRTPHRL---IL--SGSPMQNNLRELWSLFDFVFPGKL
GVLPVFMEQFSVPITMGGYSNASPVQVKTAYKCACVLRDTINPYLLRRMKSDVKMSLSLP
DKNEQV--LFCRLTEEQHKVYQ--NFIDSKEVYKILNGEMQIFSGLVALRKICNHP

ENSGT00590000083118_2_Linker_0_1 (897, 962)

DLFS
GGPRNLPGAPDHELE-ENQFGYWKRSGKMIVVESLLKIWHKQGQRVLLFSQSRQMLDILE
V

PF00271 // ENSGT00590000083118_2_Domain_1 (962, 1040)

FLRAHSYSYLKMDGTTTIASRQPLIMRYNEDSSIYVFLLTTRVGGLGVNLTGANRVIIY
DPDWNPSTDTQARERAWRIGQKKQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVLKDPKQ
RRFFKSNDLYELFTLTSPDASQSTETSAIF----------------------------AG
TGSDVQRPRRHLKRKIQPAFGID--HEV---------PKHKIAPDSNTSTNDVT-SS---
---EDKSKTIEDIVNPVTSDH--SDPSK-DDPPASSNLTVG-NTYVGEEYLQTQAVSR--
-PEGSSVVKGNGECSASPRISKTHGTPDEEST-DEKQDVSYKREI-CQVQTESISETEQV
ENNFHKHKSKTKHPSVAKEETPEKHPEKKPTPKNSKHRRDAKFEGTRIPHLVKKRQYRKQ
DTENESEAREQSNDDYVLEKLLKKS-VGVHSVMKHDVIEDGANPDYVL---VEAEANRVA
QDALKALRLSRQRCLGAASGVPTWTGHQGISGIPAGVK--SRFGQKRNSNFSVQ-PSSVS
QKEKCQDGVLKKE---GKDNLQEHFSGRAGDAHSSAGAPSSSALLAKMRARNHLILPERL
ESESAHLPEA--SAPVPSATEHDGLLVEMRNFIAFQAQVDGQASTREILQEFESKLSASQ
SCVFRELLRNLCTFHRTSSGEGIWKLKPDYC

---------------------------------MPSEGSPHCRQTQEQEPV-----RSPR
VGAEEGAPVEQEQEHG--GAAEAGECPPSPS---SACGPSTSAEDCTSAAVRRGPALLHI
DRHQIPAVEPSAQALELQGLGVDVYDQAVLEQGVLQQVDSALHEASRATQLADAEKEYHA
VLDDLTSCTTSLRQIDKIIEQLSPQAATNRDVNRKLDSVKRQKHNKEQQLKKITAKQKRL
QAVLGGAAVR--VELDHGS-LEQEDAEPG----PSCLGSMLMPAQETAWEELIRTGQMTP
FGTQVPQKTEKKPRKLMLNEASGFEKYLADQA--KLSFERRKQ-AASRRASRKAPASAQS
EPGAPA----RESKPKPRSKALSQADRRLQKHLRKLQRRALQLQFPGRPGQPRGKRPPEG
D-----SXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXDCEPRPVPRAQKRR
RKAL---VQGSDDDFSPSSGEEAEAEAAG---KGGGPSRKAVRCRDDGDGEHYKQRLRRW
NKLRLRDKE-ERLKLEDDSEESDAEFDEGFKVPGFLFRKLFKYQQTGVRW

PF00176 // ENSGT00590000083118_2_Domain_0 (591, 898)

LWELHCQQAG
GILGDEMGLVQIVAGVL----------QCAVYSAVFEGLGPTMIVCPTTVMHQWVKEFHT
WWPPFRVAILHETGSYAHRKEKLIRDIAHCHGILITSYSYVRLMQDDISRHDWHYVILDE
GHKIRNPNAAITLACK-----QFRTPHRI---IL--SGSPMQNNLRELWSLFDFVFPGKL
GTLPVFMEQFSVPITMGGYANASPVQVKTAYRCACVLRDTINPYLLRRMKSDVKMSLSLP
DKNEQV--LFCRLTDEQHKVYQ--NFIDSKEVYQILNGEMQIFSGLVALRKICNHPD

ENSGT00590000083118_2_Linker_0_1 (898, 936)

LFS
GGPKNLGGLPDEELE-EGQFGYWKRSGKMIVVESL

PF00271 // ENSGT00590000083118_2_Domain_1 (936, 1040)

LKIWHRQGQRVLLFSQSRQMLHILE
VFLRARGYSYLKMDGSTTIASRQPLITRYNQDTSIFVFLLTTRVGGLGVNLTGANRVIIY
DPDWNPSTDTQARERAWRIGQKRQVTVYRLLTAGTIEEKIYHRSIFKQFLTNRVLKDPKQ
RRFFKSNDLYELFTLTSPDASQSTETSAIF----------------------------AG
TGSDVPTPRRHLKRRAPPAFGAD--QDA---------LKCGRFPDSATLTGAAT-PA---
---EAKPKATGAEGSTVASGA--GG--L-GDAHPGGGVTAD-DGAGEET----GAGSG--
-PEAPLVTSGHGGSAASLRVSRAPGPPAQEDP-TTDQAPSAAGHS-GQVPAEPPWENGQA
GSRSWKHKSKTKHQAVAEEGALEQ----QRKPGSARHRRDAKFEGTRVPHLVKQRPYHRP
DAEPEPAAGARSGDDYVLEKLFKKS-VGVHSVVRHDAIMDGASPDYVL---VEAEANRVA
QDALKALRLSRQQCLGAASGVPTWTGRQGS-----RVR--GRFGQKRNSSLSGQRPPSS-
SAEKCQVT---------GAHIPRHFSGRVQDPDSSPAALASSSLLARMRARNHLTLPERP
ES--GVTAEA--PTPPPCATEHDELLVEMRNFIAFQARVDGQASTREILQEFESRLSTSQ
SCVFRELLRNLCSFHRTPSGEGVWRLKPEYC

---------------------------------MFHEEVPNSTHPQEQDCL-----PSQH
ANAYKDMPVGQENG-G--V-SEAGECLSSTS---CEYGPSTSAEACVLAATRRGPTLLHI
DRHQIPAVEPSAQALELQGLGVDVYDQAVLEQGVLQQVDSAMHEASCVAQLADAEKEYQS
VLDDLMSCTTSLRQINKIIEQLSPQAASNRDINRKLDSVKRQKYNKEQQLKKITAKQKRL
QAILGGAGVQ--VELDHASLEE-DDAEPG----PSCLGSMLMPAQETAWEELIRTGQMTP
FGTPAPQKQEKKPRKIMLNEASGFEKYLAEQA--QLSFERKKQ-AATKRTAKKAI--VIS
ESSRAA----IETKADQRSQVLSQTDKRLKKHSRKLQRRAL--QFQGKVGLPSGKKPLEP
EVRPEA-EGDTEGEESGSSPTDGEEEEEQEE---EEGVASLSSDDVSYELKPLRKRQKYQ
KKVP---VQEIDDDFFPSSEEEDEAME------GRGGGRKVARRQDDGDEDYYKQRLRRW
NRLRLQDKE-KRLKLEDDSEESDAEFDEGFKVPGFLFKKLFKYQQTGVRW

PF00176 // ENSGT00590000083118_2_Domain_0 (591, 898)

LWELHCQQAG
GILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRFEGLGPTIIVCPTTVMHQWVKEFHT
WWPPFRVAVLHETGSYTHKKERLIRDIVYCHGVLITSYSYIRLMQDDISRHDWHYVILDE
GHKIRNPNAAVTLACK-----QFRTPHRI---IL--SGSPMQNNLRELWSLFDFIFPGKL
GTLPVFMEQFSVPITMGGYSNASPVQVKTAYKCACVLRDTINPYLLRRMKSDVKMSLSLP
DKNEQV--LFCRLTDEQHKVYQ--NFIDSKAVYRILNGENQIFSGLVALRKICNHPD

ENSGT00590000083118_2_Linker_0_1 (898, 936)

LFS
GGPKNASGPPEDELE-EEQFGHWRRSGKMIVVESL

PF00271 // ENSGT00590000083118_2_Domain_1 (936, 1040)

LKIWHRQGQRVLLFSQSRQMLHILE
VFLRAHKYSYLKMDGTTTIASRQPLITKYNEDTSIFVFLLTTRVGGLGVNLTGANRVIIY
DPDWNPSTDTQARERAWRIGQKKQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVLKDPKQ
RRFFKSNDLYELFTLTSPDASQGTETSAIF----------------------------AG
TGSSIQTPKCQLKKRTSTVLGTD--------------PKCKKPPVSDTPANAAT-LI---
---GEKPKAAGATGRSVTSGE--SGPFK-GDHDTNGNRASS-VAFGEET----DAGST--
-LEHLSVMSGDGKHSDSPTVDHTSRPPVEAST-SEKQGSSYAGAR-CQAQTEPVPMSEQM
EGQFSKYKSKRKH-DASEEETTEKRPQPKQKAKNSKHCRDAKFEGTRVPHLVKKRRYRQQ
TSEQEGGAKDRSSDDYVLEKLFKKS-VGVHSVVRHDAIIDGSSPDYVL---VEAEANRVA
QDALKALRLSRQQCLGAASGVPTWTGHRGISGAPTGVK--NRFGQKRDSSLPVQHPSS--
LTEKTQNN-MKKE---GKAHTPEHFSGKEDGA-SVSGAPSSSSLLARMRARNHMILPERL
ESDSEHLAEA--AAVPPCGTEHDDLLVDMRNFIAFQAQVDGQASTQEILQEFESKLSVAQ
SCVFRELLRNLCNFHRTPGGEGIWKLKPEYC

---------------------------------MPNESDFQSSQTEERDCL-----QSQP
VD-NEEMTIKPEDNG----PAEVGDSGPSCS---SASEPSTALERHPSEGPRRGLALLHI
DRHQIQAVEPSAQALELQGLGVDVYDQDVLEQGVLRQVDSAIHEAGRAAQVADAEKEYRS
VLDDLTSCTTSLRQINKIIEQLSPQAATNRDINRKLDSVKRQKYNKEQQLKKITAKQKRL
QAILGGAEVR--VEMDHASLEV-EDEEPG----PSSLGSMLMPVQETAWEELIRTGQMTP
FGTQIPQKQEKKPRKLMLDEESAFEKYLGDQA--KLSFKRKKQPMV-RRVGKKXXXXXXX
X-XXXX----XXXXXXXXXXVRSDEDAFLMKHLRMCLRRALRLPLS----LRETRDPLCY
---GSMKGEDSEGDVSEYLPEESSLEVVEEEEEEERAGARL-SEGSGCEPRSAAKGRKRP
KKVT---AQEIDDDFFPSSEDEAEAPG---GGGAGGRGRKVVRCRDDGDEEYFKQRLRRW
NKLRLQDKE-KSLKLEDDSEESDAEFDEGFKMPGFLFKKLFK

PF00176 // ENSGT00590000083118_2_Domain_0 (583, 899)

YQQTGVRWLWELHCQQAG
GILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRFEGLGPSIIVCPTTVMHQWVKEFHT
WWPPFRVAILHETGSYTHKKAKLVREIAHCHGILITSYSYIRLMQDDISRHDWHYVILDE
GHKIRNPNAAVTLACK-----QFRTPHRI---IL--SGSPMQNNLRELWSLFDFIFPGKL
GTLPV-MEQFSVPITMGGYSNASPVQVKTAYKCACVLRDTINPYLLRRMKSDVKMSLSLP
DKNEQV--LFCRLTDEQHKVYQ--NFIDSKEVYGILNGEMQVFSGLIALRKICNHPDL

ENSGT00590000083118_2_Linker_0_1 (899, 962)

FS
GGPKNVRGGPEDALE-EDQFGYWKRSGKMIVVESLLKIWHKQGQRVLLFSQSRQMLNILE
V

PF00271 // ENSGT00590000083118_2_Domain_1 (962, 1040)

FLRAQNYSYLKMDGTTTIASRQPLITRYNEDTSIFVFLLTTRVGGIGVNLTGANRVIIY
DPXXXXXXXXXARERAWRIGQKKQVTVYRLLTAGTIEEKIYHRXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXX----------------------------XXXXXXXXXXXXXXXXX
XXXDVQTPKSHLKRKPQAAFGTN--HSA---------PGHPKFPGTSTSADDVT-SA---
---KKKLATLGTEVNAVTSNQ--GNPLK-DAPETTSALTGS-DRLGEEV----KAVPR--
-PEESAELSGNGDFATSPRISETHGTAGMEGL-EGKEGLSAKKES-CQIQTELPWESEQM
ENNSYKRKSKTKH-SVAEEATLEKPLTPKQ--KKSKHHRDAKFEGTRVPHLVKKRQYQKE
DNEEESKPKEQSHDDYVLEKLFKKS-XXXXXXXXXXXXXXXXXXXXXX---XXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--SRFGQKKNSRFSLPHPS-TS
PKEKCQDGLAKKD---GKDHVSEHFSGKGENAESSSGAPTSSSLLAKMRARNHLILPERL
ESENVHLPEA--PVSQPSATEHDDLLVEMRNFIAFQARVDGQATTQEILQEFESRLSASQ
SCVFRELLRNLCTFHRTSSGEGIWKLKSEYC

---------------------------------MPNEATQHSGQTQEKDLN------SPS
FNNAEETAIGPENSAAL---DKMEESFTP---SVFNNSPSTSSVVGMFEVPRKGPPVLHI
DRQQIQSVEYSAQAVELKDLGVDVYDQDVLEQGVLQQVDKAIHEANRAAQLAEAEKEYHS
VLDDLRSCTTSLKQINTIIEHLSPQAVNNKDVNRKLDSVKRQKCNKEKQLKKIKAKQKRL
QAILGGAERE--IEANLVDLEE--DEEPG----PSSLGSMLMPAQETEWEELIRTGQMTP
FGTQIPQNQEKKPRKLMLNEASDFEKYLADQA--KLSFERKKLS--KQKKKKKIQTSVDS
NTIPTS----DEKEKNKTNGKQLKTDKHLKKHIKKLQRRAV--QFQGKIKFLKEKKPLES
KKAK--YDQGSESEDSEYIPEEEEEEEEEEE------LALHATRRQDHTLKCVSKQRKQQ
NKTA---TEEIDDEYLPSSGEESI-----------GKNGKIKRCQDDGDGNYYKQRLRRW
NKQRLEDKE-QRRKAEEESEESDAEFEEGFRMPGFLFKKLFK

PF00176 // ENSGT00590000083118_2_Domain_0 (583, 897)

YQQTGVRWLWELHCQQAG
GILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRFEGLGPTVIVCPTTVMHQWVREFHT
WWPPFRVAILHETGSYANKKVTLIREIARCHGILITSYSYIRLMQDSINNHDWHYVILDE
GHKIRNPNAAVTLACKQKKKKQFRTPHRI---IL--SGSPMQNNLKELWSLFDFVFPGKL
GTLPVFMEQFSVPITMGGYSNASPVQVKTAYKCACVLRDTINPYLLRRMKSDVKMSLSLP
DKNEQSVKLFCYMVEKHHMFVPNFNFLNKKKKYMRILFLFQVFSGLVALRKICNHP

ENSGT00590000083118_2_Linker_0_1 (897, 962)

DLFS
GGPKIIKGIPDDELEEADQFGYWKRSGKMIVVESLLKIWHKQGHRVLLFSQSRQMLHLLE
V

PF00271 // ENSGT00590000083118_2_Domain_1 (962, 1040)

FLRAREYSYLKMDGTTTIASRQPLITRYNEDTSIFVFLLTTRVGGIGVNLTGANRVIIY
DPDWNPSTDTQARERAWRIGQKKQVTVYRVIVCGRTQKALYQQQIFKQFLTNRILKDPKQ
RRFFKSNDLYELFTLSSPDESQGTETSAIF----------------------------AG
TGSDVQAPKHHSKRKFHNSFPVADREDV---------NQADVSSECSTLSDANMSES-TA
DLSQGKCKEKETDD----------------------------NVHTQDKCAFTNTFSISD
EPSKTVTILGNEEKLNSLSFTESFSSTGDEGL-DTKQL-PCETKS-LQAKPDGSIESEQT
ENRFCKHKSKTKHHFVEGK-DTLKHKGQKQNSHTAKHSKDAKFEGTRIPHLVKQKQYQKH
DEEK--EENEQKHDDYVLEKLFKRSVVGVHSVMKHDAIMEASSPDYVL---VEAEANRVA
QEALKALKMSRQRCLSAVSGVPTWTGSNGLSGAPAGGK--SRFGQKRNPSLPAPQPSSKP
TKEKGQDTGLK-------NATRTHFSGKTEDGESSSGALASSSLLASMRTRNHLTLSQRT
ENENVNLQQA--SVPLSTVTEHDDLLVEMRNFIAFQARVDGQASTQEILREFESKLSTSQ
SCVFRELLRNLCTFHRGVNGEGVWKLKPEFC

---------------------------------MPNERTPYPSQTQEHSSL-----QSHC
VKNDEEMAIKQENGA-----RGMEESFPSCS---SDNGLATSAEGYALGIPRRGPALLQI
SRHQIQTVNQSAQALELQDLGVDVYDQEVLEQGMLQQVDDAFHEASHTAQRADAEKEYQS
VLDDLTSCTTSLRQINKIIEQLSPQATTNKDISRKLDSXXXXXXXXEQQLKKLTAKQKRL
QAMIGGAEVK--VEIDPASWEE--QAEPG----PSCLGSMLMPAQETAWEELIRTGQMTP
FGTQIPHKQ-KQPRRLMLNEASGFEKYLADQA--KLSFERKKKQSSNKRVRKKAAALATS
ELNSTL----NENKRDNRSTVPSKTDKRLKKQIRKLQRRAL--QFQGKVGLLTRMKPVEA
DVEE---EGASESEGSEYLPEVDEED--------EVAEATLSEVDTDYELKPLLESRTGQ
KKFT---VQKIDEDFSXXXXXXXXXXXXXX---XXXXXXXXXXXXXXXXXXXXXXXXXRW
NKLRLQDKE-KHLELEDNSEDSDAEFDEGFKVPGFLFRKLFK

PF00176 // ENSGT00590000083118_2_Domain_0 (583, 899)

YQQTGVRWLWELHCQQAG
GILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRFEGLGPTIIVCPTTVMHQWVKEFHT
WWPPFRVAILHDTGSYTHKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXX------XXXXXXX---XX--XXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXVKTAYKCACVLRDTINPYLLRRMKSDVKMSLSLP
DKNEQV--LFCRLTDEQHEVYQ--NFIDSKEVYRILNGEMQIFSGLIALRKICNHPDL

ENSGT00590000083118_2_Linker_0_1 (899, 962)

FS
GGPRNSRGLPDDESE-ENQFGYWKRSGKMIVVESLLKIWYKQGQRVLLFSQSRQMLDILE
V

PF00271 // ENSGT00590000083118_2_Domain_1 (962, 1040)

FLRSQKYSYLKMDGTTAIASRQLLITRYNKDTSIFVFLLTTRVGGIGVNLTGANRVVIY
DPDWNPSTDTQARERAWRIGQKKQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVLKDPKQ
RRFFKSNDLYELFTLTSPDVSQSTETSAIF----------------------------AG
TGSDVQKPKHRLKRKIQLAFGTD--HDI---------PKCKKLPDSNTSTNDAKS-S---
---EEKSKSIGAIVHAVASNY--SDPLK-DDPQKSSILTCS-SALLEEKYLQINVVSR--
-LEESSLVSRNKECSDSPSISKTCGTPGEEST-DEKQDLSYKGRL--QIQTEPYWENEHM
GNHFYKHKSKTKHLGVAEEETLDTHLRQKEKPKCSK-CKDAKFEGTRIPHLVRKSXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXXX---XXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXSRFGQKKNPKFSSQYPSSTS
SKERCQDGVVKKE---KKDNVPEHFSGKAENAGSVSRAPTSSSLLAKMRARNHLILPERL
ESENVSPLEA--PALHSSTTEHDDLLVEMRNFVAFQAHVDGQASTQEILQEFESKLSASQ
SCMFRELLRNLCTFHRTSGGEGIWKLKPEYC