ENSGT00560000076605_0 : Linker Region Query Results

------------------MKKIF---SKKG------------------------------
--------------------------------------------------------ESPL
GSFT----------------RLRRSGPGVSC----------------QHGDSAYSPPGYH
IRDRDLGK-----IHK---------------AAGSGNV----------------------
AK---VQQILLLRK-NG--LN-DKDKM------------------NRTAL----------
----------HLAC--ANGHPEVVTLLVDRKCQLDV--CDSENRTALIK-----------
-AVQCQEEECATILL-EHGADPNLMDVH----GN--TALHYAV-YNEDLSIAAKLLSYDA
NIEVKNKD-D---LTPLL------LAVNGKNQQIVE-YLIKKKAN--------MKAV---
-DKLES-------KR-QLISEY--KEE---MPKNPSQNSNSVDESSED------------
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---------SLSRLSG--KPGI--------------D----D--SWPTSDD---------
--------EDFDFDTKN-------------------VPKPSLTKLMTASQQSRK---SLE
AKCDIVRT------------------ENRTSFEDRNYDSE--------------------
---------------------N-------------------EDVE---------------
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-------------------------------SLS--------------------------
----------------------------------TSVKLQGFSHPT--CPSPDPLL-KPS
LKS---------------------------------------------------------
----------------------------------------LENP----------------
-----------------------------------VLTKEGTTQPATGKKE---------
---NDIGVTE----SGPPE--------------QTNNDN-------------LTYVDGVP
KNN----RGEMMSALGLGQEEDIESPWDSESI-SENLPQKYAG---------------HL
SGATDQDEKNIVNG---Q------VED----------------------------VFYIP
SFMSGSRNFKMARLEDTRNV--------------GIPVVHMESPGRYPNMKPP----IEM
-KDSALNK-----------------------------AIGMK------------------
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----------------------------------------DK------------------
---------------------------------------------QTPR-----------
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----------------------------------------------------------SA
GHDLEVTSEEEKDRLEE-------------SEINQPQVE--------EERKKHR------
---------------------------NNETEVS---ENLYDRAADG-------------
-----DDDGLIQ---------QRKSGRTG----NQPFPMKENEEC---------------
---------DSSGSALHMKE-VKKNDN--EKWTSKESRITSVFEKATLL-----------
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--------------------------------------------TGSLQVDDDSSLNE--
-------------------IDEPEG---RPPKKTSDENNE---EKNQKYSMD--------
------------------------------------------------------DF-DDL
TQSSETASEDCELP--SSNYKNLMLLIEQLG---TE--YKD--SVSLLKIQDA----VLS
CERLIEL---KKNH-------------------CELLTVKLKKMENK-------------
--VSVLQ----KELSETK---EIKSQLEHQKVE-WEREH--CTLRFALKQEEEKRRNADM
LY-EKIREQ----LRRKEEQ------------------FGKEIEIKQQLELNLRSLDMEL
RTVRSNLN-QVVQERNDTQRQLSREQNARMLQDGIL-----TNHLSK--QKEIEMTQ---
-KKEDSH--------SHEEDKD---LLQK------NHMLQDEIAMLRLEIDTIKSQNQEK
EKKYFEDIEIVKEKNDDLQKTIKLNEETVT--------KTVFQYDGQLSAL-T------A
KNTMLNSK-----------------------------------LENEKQNK---------
--ERLEAEIESYRSRLTVAIQDR--DQSETSKRDLD----LAFQRARDEWFRLQDKMNFD
LSNLKDNNEVLS--------------------------Q-QLSKAESKFNS--LEIELHH
TR-DALREKTLV-LER--VQRDL--SQTQCQMKE-----IEQKYQN-EQGKV------NK
YIGKQESVEERLSQLQSENMLLRQQLDDAHNKA---DTKERTVTDIQD----QFHAIVQR
LQAES-EKHSLLLEDRNKELISEC-NHLKERQYQYENEKAER EV--TVRQLQQELADT--
--LKKQ------SMSEASLEVTSRYRINLEDEMQDLKKKLGQVRSQ-LQEEQDQRTEAER
C-----------------------------------AERTQDHMQKLEKENSKLKVTIKK
QVDKIEQLQ----KKLLNA-----------------------------------------
------------------------------SLYEDEKE-QLKKL---TELKQSLEYN-LD
QEMKKNDELEKEITGFKNL-----LKMTK--------------KKLNE------YENE--
--EF-SFHGDLKTSQFETDIQINKLKHKIDALTAELETASSECLRLDTR-----------
-NQVL--QQELSSMRAIQKKCEKLQKNKKKLEQELVNLKSH---MEM-NMVERGQVEQY-
KQEIEERARQDI-VDKLKEVNL---FLQTQAA-SQENLEH-LRES-NIASI RSQMELRIK
DLESEV-SKMKTSQE------DINKTELEKYK----QLYLEELKVRKFLS-SKLNKTNEK
LVEVSTKLLVEKQQ---TRSLFT------TLTTRPVLEAPCVGNLSNSLDLNRKCIPSEN
LMI-PTSSPRTLNNS-MENYLTKMQQELEKNITRELEEA-AAE-----LES-----A---
--------------------SYTASPLGST---------DES----NINQDLVWKASREY
VQILKKN--YMI------------------------------------------------
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-----------------------------

------------------MNKIFSFGKKKE------------------------------
--------------------------------------------------------QSPS
RPSN--------------KPPSS------------------------FGIQTPNSTEGYL
IRSKDLGK-----IHK---------------AALRGDV----------------------
AK---VQQLLMLRK-NS--VN-DLDKV------------------KRTPL----------
----------HLAC--ANGHPDVVCLLVERKCQLNL--LDKDSRTPLMK-----------
-AIECQQEECATILL-EHGADPNLGDAR----NN--NALHYIA-SGRTKFMAEKLVKHKI
DIEAKNKE-G---LTPLL------LAVSTMNFEMAG-FLLKNGAN--------VNAL---
-DSCKR-------TA-LMIAIS--VESI--GLVTLLLQNN--------------------
---------ADY--------TLQD------IAG-WTAQT---YA-ER---YGY---PV--
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----------------------------------------------KVILTKHADLS---
--------------RELDLE-------------------VITEEE----------QEKL-
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-----------------------------------DEDENNHAQFE-EEKKH---KSSEV
EVSE-----------NVCNAA---------------------------------------
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----------------------------------------DESGL-FQQR----------
--KRGG------------------------------------------------------
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-------------------------------NSNQEFPAIRMRVL---------------
-------IG--SYPGVHRKE-VKKKNDD--KWTPEECVIAPIF-----------EK----
----------------------TYSLTGGLL-----------------------------
-----------------------------------HV--NDDS----I------------
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----------------LREVDQGD---DRPARKTPYEKKK---ILCQRNSVN--------
------------------------------------------------------DL-DDL
TQSSETDSEDGDVL--CSSNPSFLN-VTTLPQGNLSCTQSMSSSVILLKIQDT----ILS
HERLVDF---QR-------------------SHCELIRGEFYRMKFK-------------
--VRGLQ----KELSETK---VVKSQLKHQKVE-WERERSSLSKEAEVKQHLELTLQAVE
MKLKPERNN----L--NQVDVRGTFRLIVKN-KRKEIQNSQRNKAR--TE-SSRTGV---
------------------NRNKARNKNC-----VIL-----TCWVHFFEQREEEVTSVAH
TIDPEKPQSSQ-VSDSCEEAKD---LLHK------NHMLQDELATLRLEIDALK-QHWEK
EENYFENMEILKVKNDDLQKAVKLTE----------------------------------
-NTMLTSK-----------------------------------LENEKESK---------
--QRLETEVKSYRSRLAAALHDH--DQGQTSKRDLE----LAFQRARDKWLCLQDKMQFD
VANLRDNNEKLS--------------------------Q-QLSTVESIFNK--LKIKLHH
MR-DDLREKTLM-LER--VQRDL--SQSECQKQK-----IEHMYQN-EHSKV------NT
YFRKHKSLEKRLSQLQSENVLLRQQLGNARNRA---DSKEKVVISIQD--------ILRK
LQAER-KKQGLMLEERNK----EC-NHLKERMYWYENEKAEGEV--SIQKEKA-FSP---
----------------THSFLSGREVVK-----------LCRFIGR-GGHGQWSR---IF
CLSW-----------------------------------KV---------APSLSVTRFS
E-----------------------------------------------------------
-------------------------------EE---KG-EVLSV---NALVSFFFFP---
--SFSIQMY--ILFTLRKVENCASLFTQVESLFFLNSCITMMRQARKSEDNISLMERSD-
---ISSMRGNLGS--LSSLANSIILFLKTDNYPAELETASSKCLHLDAK-----------
-K------------------------------------------KKM-NMIEHSQVEQY-
KGEIEERVRQDL-VEKLKKVDL---FCREQ-I-YFSRLMIILKMLSFSICLRHKMELIIK
DLESEL-SKMKSLQEDS------NKAELEKCK----QLY-LEREVIKSLE-DKLDKTHER
LAVISTKLEVKKEQ---NRCLLS------PLSTRPVLEPPCVRNFNNPLVPSGNLTPRAN
IGF-STSIPCPSNNS-TETYLTE-------------------------------------
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-----------------------------

------------MPIASAIRRLFGLSSRGR------------------------------
--------------------------------------------------------V-P-
--------------------------------------------SDPSGLEGSCGDPQHR
ARPKAVGK-----LHK---------------AASVGDT----------------------
VK---VEQRLMLRK-SG--VN-DRDKK------------------HRTAL----------
----------HFAC--VYGHPEVVTLLVEKKCDIDA--HDRENSTALIK-----------
-AVQYHQEECATILL-EQGANPNVSDAS----GN--TALHYAV-YYENSSIVAKLLSHHA
DTEAKNKD-D---LTPNL------LAVRENKQQVAE-LLIKKKEN--------THAL---
-DEPGR-------YS-CSFIKI--RL----------------------------------
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MVA-----EVCSMPAASAVKKPFGLRSKMGKWC---------------------------
----------HHPLPCCRGSGKSNMGTSGDHDDSFMKTLRSKMGKCCHHCFPCCRGSGTS
NVGTSGDHDNNFMKTLRSKMGKW-CCHCFPCCRGSGKSNVGTWGDYDD---SAFMEPRYH
VRREDLDK-----LHR---------------AAWWGKV----------------------
PR---KDLIVMLRD-TD--MN-KRDKQK------------------RTAL----------
----------HLAS--ANGNSEVVQLLLDRRCQLNV--LDNKKRTALIK-----------
-AVQCQEDECVLMLL-EHGADRNIQDEY----GN--TALHYAI-YNEDKLMAKALLLYGA
DIESKTRY-R---STNFI------FKILKCIRVNID-L----------------------
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--------------------------------------N---LV-SY---IFI---HR--
--ICELLSDYKEKQMLKISSEN--------------------------------------
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--------------------------------------------NNPGK-----------
---------EAEE-----------------------------------------------
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--------------HR---------------AAASGDL----------------------
AQ---VRQG--LRK-HG--ID-ERDKA------------------QRTPL----------
----------HLAC--ANGHVDVVTYLVENKCKLNL--FDNDNRSPLMK-----------
-AVQCQKEKCVAILL-EHGADPNLADAS----GN--TALHLAA-AAPNASLAEMLLEHNA
HIDAQNKE-G---YTPLI------LAVLEHHEEMVE-FLLKKGAD--------VHAR---
-DQCER-------SN-QLIWLY-------------------------------------V
RMMC-PRG-SRQ--------C----------------SN---AI-AL---FYF---DN--
--VSKSLYYYKI---CGLKRTSI-------------------------------------
VSHFVT-------SLYA-------------------------------------------
------FVIKSIS------Y-------------------------------FC-------
-------V----------------------------------------------RA----
----SEPWFSFLRSSE--KEGN--------------D----D--SWHTSEE---------
--------EELDFTPKK-------------------PQKPNLTLLMNASQQFKKNKSEKS
SSMRTEHI---------------------VIL----------------------------
------------GQNNQDEKEE-------------------EDLEDE-------------
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---------ETQSNSIMEEEQ------GREIEPKGIHTK-------T-------------
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------------------------------------SCP---------------------
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-----------------------------------TKSKEELLKWEEE------------
EKEDACGELQ----TAASE--------------GVKNYVHS--------NTHQDHNASED
TA-------GALPALGAEQEEEAESPWDSETD-SDSLRKVSP-G--------------VL
LPAADEHGACLQSVSVER------NNG---------------------------------
-NFLLKISASVLEMNETSPRRGRR---------------KSGECSDSAFHVSSSGEKEAI
-KDTIENY-------------------------------GRQ------------------
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----------------------------------------VASSG-------------M-
-----RES----------------------------------------------------
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--------NNK--LENNT----------------------------------KEE-----
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---------------------------ENK-------VPT---TEME-------------
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----ENKDYLIKNNKIGEAEIET-FPRFNGPVHI--------------------------
------------------------SYSS--------------------------------
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--------------SMEAKV-VKKNES--KRQSSKQ----KANQRMSS------------
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-------------------------------------------SSGNHFQVLDDSTFSE-
-------------------TSQDEE---RPAAKTGSEKNK---VIVQMDVMD--------
-------------------------------------------------------N-LDL
TQSSDTTTEDVESP--TPTYKEAMLLLEQLG---VD--HAG--SVILLKIQNI----LLQ
YEQIIER---EKSR-------------------YAALSREVRKLESE-------------
--KEESQ----LIAEETQ---DLKSILAHQEVE-WKSDI--QSLKFSLKQEEEKRLRVEM
LY-EKTREQ----LRRKEDQ------------------YCKEMEKKQQLELHSGNLQTEI
ITLRKLLK-QVEEERDETQRQLSQEKSARALQEGIL-----NSHLWR--QKELEEET---
-RITIGKNSE--ESDTNEREKD---LLYK------NQLLQDEIAMLRLELDQVKLRHQED
EGKYLEENETLKEKNEDLKKELKLNEEALT--------QTVFQYNGQLNLL-K------T
ESAVLTSK-----------------------------------LEQTKESK---------
--DRLETEIESFRSRLNAAVQDL--ERHQTSKSDVE----RTFQRERDEWLRLQDKLHHD
LSDVRETNNSLS--------------------------Q-QLSKAESKANT--LENELHQ
LK-QTLREKTLL-LEM--TQKEL--SQAQCQAKE-----SDHARQL-EKDQV------SK
FMIKQESMQERLAQLQSENLLLRQQLEDMQNKG---IIKEKVVNDVQD----RFNDIFNK
LRADT-EKQVYLMEERNKELKTKC-TDLREQVFKYEADKVERE--GMVRQLQQELADA--
--LKKQ------SMSEAALEVTTHHRSDLEEDKLRLQKELDKVKTK-LQESEQQRIQSEH
CVHDLKTVLDNKE--------------------------------RLEIENARLEATAKQ
QTNRIEALQ----KDLQTS-----------------------------------------
------------------------------ASCESERK-KVKKL---IELKRPVEVR-LD
QEMKRNIELQKECHRCKRL-----LNRAM--------------KKIRM------YEARER
ESQF-NFQGEIKNRYSEMVNEVGRLRTKVSELSQQLELESKKCMQLEAQ-----------
-NQDL--REELSALR---GNHEILEKSKCQLKEEVANLRHR---LET-NMVDHSQIEQY-
KREMEERAGQEI-RQKLQEVNL---FLQTQAA-SQDRLEQ-IRAS-HHASLRNQLKHRIK
DLECEL-DRIKNTQQ-----KESTQAEVEKYK----ELYLEEVKIRRCLA-NKLERANER
LAEANAKLLQERHR---SKSLIASSIVGGGLAASPVLYSTELGHLGNNLALNRSLSLGGS
FLG-PPGNALSSRNR-VEAYVAKIRRELDEKITKELEQA-TAE-----LET-----G---
-------------------S-AGASPMVST---------DGSSKNFNVDQDPLCKAIQEY
RDVLTKN--YLI------------------------------------------------
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-----------------------------

------------------MKRVSAAAVKGE------------------------------
--------------------------------------------------------TGPE
RPSP-------------------------------------------FSQLVYTNNDSYV
IHHGDLRK-----IHK---------------AASQGQA----------------------
WK---LERM-MKKTTMDLN---IRDAK------------------KRTAL----------
----------HWAC--ANGHAEVVTLLVDRKCQLDV--LDGENRTPLMK-----------
-ALQCQREACANILI-DSGADPNIVDVY----GN--TAVHYAV-YSENLSVVVKLLSCGA
DIEVKNKA-G---HTPLL------LAIRKRSEQIVE-FLLTKNAN--------ANAV---
-DKFKC------------------------------------------------------
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---------------I--H-------------------------QQLLEYKQ--------
-----------K------------------------------------------------
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--ISKNSQ-------------------------------------------NS-------
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-------------------------------------------------NP---EGTSEG
TPEEA-------------------------------------------------------
-------------ASLAER-------------------------------------I-PD
KAK---------------------------------------------------------
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-------------------CSV--ERTPDE------------------------------
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------------------MRKLFSFGRRLG------------------------------
--------------------------------------------------------QALL
SS----------------------------------------------RD-KEYAGPGYH
TRDWELRK-----IHR---------------AAIKGDA----------------------
AE---VEHIAL-QF-P----E-ISSYS------------------PRTVL----------
----------HLAC--AHGRVEVVTLLLNRTPLMKV--FK-INLS---------------
--HLNITKACAIILL-EHGANPNIKDIY----GN--TALHYAM-YNKGTSLAEKLLSHRA
NIEALNEE-G---NTPLL------FAINSRRQQMVE-FLLKNQAN--------IHAV---
-DNFRR-------TA-LMLAVQ--HSSS--SIVSL-------------------------
--LL-QQN-INI--------FSQD------MFG-QTAED---YA-VC---CDL---RR--
--YILILG----------------------------------------------------
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------------------MEKLFWFCRRKDQT----------------------------
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------------------------------------------------------CGVGSS
LQSKRSKK-----LHK---------------AASAGDS----------------------
EK---LRQYLQLK-KYD--VN-MQDKD------------------RXXXXXXXXXXXXXX
XXXXXXX--------------X------XX-XXXXX---XXXXXXXXXX-----------
-XXQFQKENCASLLL-SHGADPNLADSQ----HN--TALHHAV-CGQSLSLVEKLLKHKA
NLEAKNKD-G---YTPLL------LAVTENKEEMVE-FLLKKGAD--------VNAS---
-DKNQR-------TA-LMISLT--EEPT--NTVSH-------------------------
--LL-QYD-------------------------------------VD---LSCTDITDLQ
LKNMLPLTV--------------------------------------SPSRYHELTANY-
GKNKK--AKH--------------------------------------------------
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--MAS---------------RGGEKRGGSEGSPKPTVSAMRKTPSV--------------
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-------------------------------------------------GSVRSQEDQL-
----------SLSYQGDRWSSDSSYSAGSDSAGSDSE--------H-------------V
EGAL--------------------------------------------------DQP---
-----QHDVCLEDPCELHRA--------------ARSGD-------VP-----GVERVLA
PGD-----------------------------------PGVNKRD-RKESLWHLIPECKM
EQSPESLPQNNNPDWHPTNLTVSDKTCQKSKILSVDDQCPSVSPSMPENQSAVKELGQMN
LTEQEKM----------N---------------------VSGNGSLH--DLC-QSQLPE-
----------------------NKESK---------------E------AEQDLELTSEE
E---QERLKGHENKQPQ----KMSQEPEMAKDCDRED------------------IPVYS
ILPHAQKSEEMWIEQGKLEWKNKLKL-----------VTNELKQRFGE------------
------IRETYKIP----------------------------------------------
----VCPEEEPLLDNSMRKTNVKDIPFNLTN-N-------------------------IP
GCVEEDASEVSVSVVFETFPEKNEPSLKSIIH---------PYSHPYSGSLEHACQSSSK
LHLHENKLDCDSDNKPGIEHIFSMDEN-FSNDAGTKKAR-NPEEVTVEMKE-----D---
QEF-DLQMTKNMNQNSDSC-----------------------------------------
---------------------------STNNYKSLKPKL-E--NL-SSLPPDSDRTSEVY
LHEELQ---QDMQKPQTEVDRVEEMF-----LALKKENVQLQKEVEEEVEKQ---RSNST
ELSG-----------NPAHGAAAG------------------------------------
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---------------------------------------NNDDGL-NQQ-----------
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------------------------------------FPRKK-------------------
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----------------------KKGH-DRPADKTSNEKNK---VKNQVH-----------
---------------------------------------------------PEADF-ADS
VGPSETTSEDCELS--HSTYENFLLLIEQLG---ME--CKD--SVSLSRIQDT----FCF
YEHLLEL---KNND-------------------YEQLTVKIKQTENM-------------
--VSVLQ----KELSETK---KTKLQLELQKIE-LEKQL--YSLRLALKQEKEEKGNAVM
LY-NKYSER----LRLKEEE------------------CGKEVEMKQRLKWTLRRLVKEL
KTVRNNLD-LVVQERNDVQKQLSEEQNARILQDQTL-----TS---K--QKELE------
--IAQKKINSE-ISHRHKKEKD---LLHE------NCMLQEEIALLRLEIDTVNNQNQQK
EKKYFEDIEVVKEKNDNLQKIIKLNEEKLT--------KTILQYSGQLNNL-TA------
ENKRLNSE-----------------------------------LENKKQNQ---------
--ERLEIEMESYRCRLAAALRDCDCDQSQT-SRDPK----LDFQRTRQEWVHLQDKKKVD
MSDLQAKTEILS--------------------------E-KLSNAESKISS--LQIELHN
TR-DAVERKSLI-LEH--LQRDL--SQTHCEKKE-----IEQMYQT-EQRKL------KK
YIAKQESVEERLSQLQSENTLLPQQLDDAHKKA---NSQEKTISTIQD----QFHAFAKN
LQAES-EKKILSLQEKNKELLDEY-NHLQERMHQCEKEKAR RKV----------------
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------------------------------DLIEAQETAPLRCLHLDAE-----------
-NEVLQLQQTLFSMKAIRKQCETLQKNKKQLKREVVNLKSY---MER-NMLECVEAEQH-
KLLIEEKAKKEI-AEKLNEAVL---TLQKQAAVSQEQLAQ-LRED-NTTSV KTQMELTIK
NLESEI-SRINTSSADF------NKTELERYK----ELYLEEVKVRESLS-NELNRTNEK
IAEVSAQLTVKKELTR---SPFA------ACSTRPILEPPCAGNLNDSEDLNRKHIPRKK
KSA---------PES-MESYLLKMQQKFQNDVTREVTAA-TKCEPEPYVAS-----P---
----------------------PESA-----------------YQKNLNQDPVLEATKEY
AQILSRK--YMI------------------------------------------------
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-----------------------------

------------------MKKLFNIWRR--------------------------------
--------------------------------------------------------KDEP
-------------------HSQAII--------------------------GPSAYPGYN
LRDKGLKK-----LHQ---------------AAAVGDL----------------------
EK---VMKYLRLKK-QD--VN-MQDRE------------------HRTPL----------
----------HLAC--ANGYSNIASLLLEKKCKENI--LDGESRSPLTK-----------
-AIQCDKESCAAILL-EHGADPNLVDLN----GN--TALHYAA-SHQRVSLAKKLLEHKA
NLEAQNKD-G---YTPFL------LAVTENNVEMVK-FLLKSGAD--------VNAS---
-DKNQR-------TA-LMIALS--NEPT--SLISL-------------------------
--LL-QQE-VDL--------SCQD------IYG-FTAEE---YA-SF---NGF---TI--
--RRTHAAHT--------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-----------------------------

------------------MKKIF---SKKG------------------------------
--------------------------------------------------------ESPL
SSFA----------------RRRRSSAGGGG----------------ELGEGAYSQPGYH
VRDRDLGK-----IHK---------------AASAGNV----------------------
AK---VQQILLLRK-NG--LN-DRDKM------------------NRTAL----------
----------HLAC--ASGHPEVVTLLVDRKCQLNV--CDNENRTALMK-----------
-AVQCQEEECATILL-EHGADPNLADVH----GN--TALHYAI-YNEDIPVATKLLLYDA
NIEAKNKD-D---LTPLL------VAVNGKKQQMVE-FLIKKKAN--------VNAV---
-DKLES-------SH-QLIPEY--KEER--IPKNSSQNSNSGKTSDSGLLL-VNTM----
-------D-K-------------K------V-----------------------------
--------------------EVR-------------------------------------
KTE---------------------------------------------------------
---------------------------------------------------FT-------
-------H----------------------------------------------------
F-----------------------------------------------------------
-------------------------------------YIFFLAKLMTASQQSRK---NLE
ATYGIVRT------------------GSRTLFEDRDSDSQ--------------------
---------------------D-------------------EVVV---------------
------------------------------------------------------------
-----------------------------ESLPT--------------------------
----------------------------------TSVKAQGFSHPT--CQSPDPLP-KPS
HKS---------------------------------------------------------
----------------------------------------LANP----------------
-----------------------------------GLIKEGPTKPAVGKKE---------
---NGIDIIE----SAPLE--------------QTNSDN-------------LTYVDEVH
KNN----RSDMMSALGLGQEEDIESPWDSESI-SENFPQKYVD---------------PL
AGAAYQKEKNIGNE---Q------AE----------------------------------
-----------------------------------------ESPERYLHLKPA----IEM
-KDSVPNK-----------------------------AGGMK------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------DV------------------
---------------------------------------------QTSK-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------AA
ERDLEVASEEEQER-EE-------------SENNQPQVE--------EERKKHR------
---------------------------NSEMEVS---ANIHDGATDND------------
-----EDDGLIQ---------ERRSGETD----DQQFPRKENKEY---------------
---------ASSGPALQMKA-VKR--------TSKESVNSPVFEKAGLL-----------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------TGGLLQV---------
--------------------------------------------KNQIQSMD--------
------------------------------------------------------DV-DDL
TQSSETASEDCELP--RSSYKNFMLLIEQLG---ME--CKD--SVSLLKIQDA----ALS
CERLLEL---KKNH-------------------CELLTVKIKKMEDK-------------
--VNVLQ----KELSETK---EIKSQLEHQKVE-WEREL--CSLRFSLNQEEEKRRNADM
LY-EKIREQ----LRRKEEQ------------------YRKEVEVKQQLELSLQTLEMEL
RTVKSNLN-QVIQERNDTQRQLSREQNARMLQDGIL-----TNHLSK--QKEIEMTQ---
-RKMNSETSH-----SHEE-ED---LLHK------NSMLQEEIAMLRLEIDTIKNQNQEK
EKKCFEDLEIVKEKNEDLQKTIKQNEETLT--------QTISQYNGRLSVL-T------A
ENTMLNSK-----------------------------------LESEKQSK---------
--ERLEAEVESYRSRLAAAIHDR--DQSETSKRDLE----LAFQRARDEWSRLQDKMNFD
ASHLKDNNEILS--------------------------Q-QLFKTESKLNS--LEIELHH
TR-DTLREKTLG-LER--VQKDL--SQTQCQMKE-----MEQKYQN-EQVKV------NK
YIGKQESVEERLSQLQSENMLLRQQLDDAHNKA---DNKEKTVINIQD----QFHAIVQK
LQAES-EKQSLLLEERNKELISEC-NHLKERQYQYENEKAER EV--VVRQLQQELADT--
--LKKQ------SMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQ-LQEAQDRHTEAVR
C-----------------------------------AEKMQDHKQKLEKDNAKLKVTIKK
QMDKIEELQ----KNLLNA-----------------------------------------
------------------------------NLSEDEKE-QLKKL---MELKQSLECN-LD
QEMKKNVELEREITGFKNL-----LKMTR--------------KKLNE------YENG--
--EL-SFHGDLKSSQFEMDIQINKLKHKIDDLTADLETAGSKCLHLDTK-----------
-NQVL--QQELLSMKTIQKKCEKLQKNKKKLEQEVVNLRSH---IER-NMVELGQVKQY-
KQEIEERARQEI-VEKLKEVNL---FLQAQAA-SQENLEQ-LREN-NFASM KSQMELRIK
DLESEL-SKIKTSQE------DFNKTELEKYK----QLYLDELKVRKSLS-NKLNKTNER
LAEVSTKLLVEKQQ---SRSLFT------TLTTRPVMEPPCVGNLNNSLDHNRKLIPREN
LVI-SSSNPRTSNNS-VENYLSKMQQELENNITRELEEA-AAE-----LES-----G---
--------------------S-IASPLGST---------DES----NLNQDLVWKASREY
VQVLKKN--YMI------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

----------------MKKILVHG----VK------------------------------
---------------------------------------------------------EKT
PLGF--------------CDVPRKNLLDFLR--------------DM-----KSISVPNE
PRYKPLRK-----IHQ---------------AASDGDT----------------------
ER---LQRMISLG-KHS--VH-DRDFK------------------ERTAL----------
----------HFAC--ACGQVEVVSILLRNNCDIDA--ADMNFITPLMK-----------
-AVQNWTYECVCILL-KHGADPNRKDKN----GN--TSLHYAV-SEDNQTLAKCLLKYSA
NMEQKNKD-G---FTPLL------LALKENKIEMAK-FLVKMGAN--------IHVF---
-DDMRR-------NT-LLYAIR--WDSK--DMVNL-------------------------
--LL-DEG-IDF--------FFRD------VFG-WTALR---YA-IE---GTS---K---
-GSREILMNYDEMLRRKNKDGIPEYKFFEDK---------------------SLDKHPN-
NPTSGSTFPKSNENACKFDDELDI------SKYVLGTCPNNIHGAGEEGDKSETKKAADV
Q------VWTNPTL----------KSSTKGKV-----PNLNEVGTMTESHHFIK------
------ESDLEI-----------------------------ESLVETFSYDNEDKQ--SM
--------SDDGHFSG--TTPK-----------WCQN---DT--NRKTTVQD--CMYP--
-----------NLKSPT------------------EGKIPTR-SKAGKMAESA-------
-------------HFIIESDLEIESLEETVSCDSE-----DK------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------QLLV----------------------------------------------
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-----------------------------

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-----------------M--------KLFGFGSRR-------------------------
----------GQTAQGSI------------------------------------------
------------------------------------------------------------
----------------------------------------------DHV-----------
------------------------------------------------------------
-----YT--GSGY--------------------------------------RIRDS----
V-----LQKIHRAAVKGDAAEVERCLARRSGDL---------------------------
------------------D----AL-D-------------KQHQALPV-------ASEEE
QERHERS---EKKQ------------------------PQVKEGNNTNKSEKIQLSENIC
DSTSSAA---AGRLTQQRKIGKTYPQQF-------PKKLKEEHDRCTLKQENEEKTNVNV
LY-KKNREE----LERKEKQ------------------YKKEVDAK-QLEPTVQSLEMKS
KTARNTPN----------------------------------------------------
----------R-DFHNHEEKKG---LMDE------NCILKADIAILRQEICTMKNDNLEK
ENKYLKDIKIVKETNAALEKYVKLNEEMIT--------ETAFRYQQELNDL-KA------
ENTRLNAE-----------------------------------LLKEKESK---------
--KRLEADIESYQSRLAAAISKH--SESVKTERNLK----LALERTQDV--SVQVEMSSA
ISKVKDENEFLT--------------------------E-QLSETQIKFNA--LKDKFRK
TR-DSLRKKSLA-LET--VQNDL--SQTQQQTQE-----MKEMYQN-AEAKV------NN
STGKWNCVEERICHLQRENAWLVQQLDDVHQKE----DHKEIVTNIQR----GF------
--IES-GKKDLVLEEKSKKLMNEC-DHLKESLFQYEREKAEGVV--SIKEDKY-FQTS--
--RKKI------------------------------------------------------
------------------------------------------------------------
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-----------------------------

-----------------------MED----------------------------------
--------------------------------------------------------DEPK
RWPT--------------FRE----R---LC-------------------SDGFSFPQYH
IKLSHLKR-----IHR---------------AVFYGNL----------------------
EK---LEY-LLFV-YHD--AN-KRDKK------------------ERTAL----------
----------HLAC--ATGQPEMVFLLVSARCELNL--CDCECRTPLIK-----------
-AVQLRQKACATTLQ-QNGANPNIXXXX----XX--XX----------------------
------------------------------------------------------------
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-----------------------------

------------------MRKLFSFGRRLG------------------------------
--------------------------------------------------------QALL
DS----------------------------------------------MD-QEYAGRGYH
IRDWELRK-----IHR---------------AAIKGDA----------------------
AE---VERCLTRRF-RD--LD-ARDRK------------------DRTVL----------
----------HLAC--AHGHVEVVTLLLSRRCQINI--CDKLNRTPLMK-----------
-AVHCQEEACAIILL-EHGANPNIKDIY----GN--TALHYAV-YNEGTSLAEKLLSCHA
NIEALNEE-G---NTPLL------FAINSRRQQMVE-FLLNNQAN--------VHAV---
-DNFRR-------TA-LMLAVQ--HNSS--SIVNL-------------------------
--LL-QQN-INI--------FSQD------LFG-QTAED---YA-VC---CNF---RS--
--IQQQIL---E------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------H--------------
------------------------------------------------------------
-------------K-----------------------------NK-------I-------
-----------------------------LK----------NHLR---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------N----------------------------------------------------
------------DNQETAA-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------MK-------------------------------------------PG-------
------------------------------------------------------------
-------------------------------------------------SL--K------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------K
------------------------------------------------------------
----------------------------RK-------EGAKGKTF---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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---------ECLYS----------------------------------------------
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-----------------------------

-----------------------------G------------------------------
--------------------------------------------------------GGGG
GGGG---------------------------------------------G-VPCPAGAYE
LRQKDLGK-----LHR---------------AAASGDL----------------------
AQ---VRQG--VKK-YG--TD-GRAKA------------------ERTAL----------
----------HLAC--ANGHVDIVMYLVENKCKLNL--FDNDNRSPLMK-----------
-AVQCQQEKCVAILL-EHGADPNLADAD----GN--TALHLAV-LSSNTTVAGLLLEHNA
NIDSQNKE-G---YTPLI------LAVSEHHEEIVE-FLLRKGAD--------VHAR---
-DQCER-------FL-RVLLGN--------------------------------------
--YV-ANG-QKT--------VVKH------SSL-WNYVA---------------------
---------------NGAEDSG--------------------------------------
QTQFIIPLNTVPYSIFK-------------------------------------------
------YVKKTCTQKVQVLYH---------------QFSLLQ------KLAFV-------
-------Y----------------------------------------------RVM---
YCSFHVPGSLLHRSSE--KEEN--------------D----D--SWHTSEE---------
--------EELDFTPKS-----------------------NLTLLMSASQQFRKNSN---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------KAKH
EGDAQCG------------TGDVCDDHE-ITKEHDEKVKDSVDTPV--SFIAGSCEKFQQ
KKTQDLKAYLSH----------------------------------------ISIFS---
------------------------------------------------------------
----------------------------------SSLFNEESSDY---KEE---------
EKDGAGRKLQ----TTGVE--------------DVKNSVCN--------DRHEVHKASKD
N-------SGTLPTVGAEQEEDAESPWDSEHL-EQNFTSFQE-L--------------QI
SI----NGKEFDLEDVED------IEG----------------------------IHDH-
-------LCPVLSWTDTLPHT--------------LEGMHYCEYSGSTFHMSSAAEKEDD
-KDAVENY-------------------------------GVW------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------VFCER-----R----TKKE-
-----TTNLIEKSARENET----DKAEVSHQKALTKREKSHSADKESNLKTWEERYERKG
--------------EKKKM-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------PT---METE----------END
NGSSKNAEEGPAYSLR--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------HS------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------LNGNNFRVPDDSTSSE-
-------------------VSQEEG---RPAAKTASERNK---VRIQMDVTD--------
-------------------------------------------------------D-LDL
THSSDTTSEDVKLP--TSTYKEAVLLLEQLT---VD--HTG--SAILLKIQNI----LLK
YEQIIEH---EKNR-------------------YAAVSREVRKLESE-------------
--KEKSK----LIAEETQ---DLKSVLAHQEVE-WKSDI--QSLKFSLKQEEEKRLRAET
LY-EKTREK----LKRKEEQ------------------YSKEMEEKQQLELQSRNLEMEL
VTLRKLLK-QVEDERDETQRQLSQEKSARALQEGIL-----NNHLWR--QKELEEET---
-RRTIGKSSD--ESDT-EREKD---LLYK------NQLLQDEIAMLRLELDQVRLRHQEE
EGKYLEENETLKEKNEDLQKELKLNEETLT--------QTVFQYNGQLNLL-K------T
ESAMLTSK-----------------------------------LEQTKESK---------
--DRLETEIESFRSRLNSTVQEL--ERHQSSKSDVE----RTFQRERDEWLRLQDKLHHD
LSDVREANKSLS--------------------------QQQLSKAESKANS--LENELHQ
LK-QTLREKTLF-IEM--AQKEL--SQTQCQAKE-----YDHVRQL-KKDQV------NK
LTIMQKSLQERLAPPQSENLLLCQQLEDLQNKQ---TQSEKVVNDVQD----RFNYIFNK
LRADP-EKQVYLVEERNKELNAKC-IDLRGQVFKYETDKIERE--GTIRQLQQELADA--
--LKKQ------SMSEASLEVTTRYRSDLEEDKLRLQKELEKAKI---------------
--------------------KKLQDQLLASSETNTTIKQLEEHVQHLEIENTKLEATVQQ
QSNRIEALQ----RDLQAS-----------------------------------------
------------------------------ASCESERK-KVKKL---IELKRPVELR-LD
QEMRRNLELQKDFKRLKRL-----LSRAT--------------KKIRV------YEEREV
ESQL-NLKGEMKSRYSEMITEVDRLRTKVAELSQQLDMESKKSMQLEAQ-----------
-NRDL--REELSALH---GNCEKLEKSKCQLKEEMAKLQRH---LET-NMVDHSQIEQY-
KREVDERAGQEI-RQKLQEVNL---FLQAQAA-SQDRLEQ-IRAS-HHASLRNQLKDRIR
DLECEL-DKIKNTHKKHS--TNCAQAEVAKYK----ELYLEEVKTRKSNWESVTTKANER
LEEANAKLLRERHK---NKSLITSSIVSGGLAATPVLYSTALGHLGNHLGLNRSLSLGES
FLS-PTENTLSSRNR-VAAFVAKVRQELDEKITKELKEA-TAE-----LDT-----G---
-------------------C-G------------------GSSKNLHVDQDPLCRAIEEY
RDVLTKN--YMI------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------RTAL----------
----------HWAC--ANGHAEVVTLLVDRKCQLDV--LDGENRTPLMK-----------
-ALQCQREACENILI-DSGADPNIVDVY----GN--TAVHYAV-YTENLSVVAKLLSCGA
DVDVKNKA-G---HTPLL------LAIRKRSEQTVG-FLLTKN-N--------ANAV---
-DKFKC-------TG-LMLAVC--HGSL--EIVGMVLQQN--------------------
---------VDI--------YAED------TCG-MTAEC---YA----------------
--------------------VAC-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------G--------------
----------FN--LI--H-------------------------QQLLEYTQ--------
-----------K------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--LSKNSQ-------------------------------------------NS-------
------------------------------------------------------------
-------------------------------------------------NP---EGTSEG
TPDEA-------------------------------------------------------
-------------APLAER-------------------------------------T-PD
MAE---------------------------------------------------------
------------------------------------------------------------
-------------------SLV--ERTPDE------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-----------------------------

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------------T--A--LHLACASG--H------E----KVVTL-LINR----------
--KCQI------------------------------------------------------
-----------------------------------------------------DICDKEN
R-----------------------------------------------------------
-----------------T--------PLIQAGSSD-------------------------
----------ESA--VSI------------------------------------------
------------------------------------------------------------
----------------------------------------------FHE-----------
------------------------------------------------------------
-----LC--VDSL--------------------------------------PTSDDEDMS
VAAKKCVPKYVSQPLPGPSHEKGNGIV-----S---------------------------
------------------G----KG-K-------------GEEQALLV-------ASEEE
QERHERS---EKKQ------------------------PQVKEGNNTNKSEKIPVSENLC
DRTA--A---ADRLPQQRKTGEMHPQQF-------PKKLKEERDRCTFKQENEEKINVNM
LY-KKNREE----LDRKEKQ------------------HKKEAEAK-QPEPTVQSLEMKP
KTARSTPN----------------------------------------------------
----------Q-DFHTHEETED---LMDE------NCILKTDIAILRQEILTMKNDNLEK
ENEYLKDIKIVKERNAALEKSIKLNEE-IT--------KTAFQDQQELKDL-KA------
ENKRLNSE-----------------------------------LLKKKES----------
-----------------------------NTERNLK----LTLQNTQDI--SVQEKMSSD
ISEVEDKNEFLT--------------------------E-QLSKTQIKFNT--LKDKFPK
TR-DTLRTKPLD-LET--LQNDL--SQTQQQIKE-----MKEMYQN-AEAKV------SN
STGEWNCVEERICQLQRENLCLEQQLDDDHQKE----DHKERVINIQR----GS------
--IES-GKKDLLLQEKNKKLMNDY-DHLKESLFLYEREKAERVV--SIKEEKY-FQTS--
--RKKM------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------MNKLFSCWKRRHET----------------------------
------------------------------------------------------------
------------------------------------------------------PSQTYK
LLDKDVKK-----LHR---------------AASLGDL----------------------
KK---LKKYIQVK-KYD--VN-SQDEE------------------YRTG-----------
---------------------------------------------WGGS-----------
-SIQCQKEDCANILL-NYGADPNLMDFC----YN--TALHYAV-CGKSFSLVEKLLKHKA
DLEAKNKD-G---CTPLL------LAVIKCNPKMLK-FLLDKGAD--------VNAT---
-DNYQR-------TA-LIIAVS--GEAT--CVQRS-------------------------
--LL-QKG-------------------------------------VE---LSSEEYAFLN
DTHNQWRVM--------------------------------------ERRKMLSRHLIL-
GTTCD-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-----------------------------

MVA-----EVGSMPAASAAKKPFDLRSKMGKWC---------------------------
----------RHRFPCCGGSGKSSVGTSGDHDDSFMKTFRSKMDKWCCHCFPCCGGSGKS
NVGTSGDHDDSFMKTLRSQMGKW-CRHCFPCCSGSGKSNVGAWGDYDD---SAFKEPRYH
LCREDLDK-----LHR---------------AAWWGKV----------------------
PR---KDLIVMLRD-TD--VN-KRDKQK------------------RTAL----------
----------HLAS--ANGNSEVVKLLLDRRCQLNV--LDNKKRTALIK-----------
-AVQCQEDECALMLL-EHGTDPNIPDEY----GN--TALHYAI-YNEDKLMAKALLLYGA
DIESKNKY-G---LTPLL------LGVHGQKQQVVK-FLIKKKAN--------LNAL---
-DRYG-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-----------------------------

-------------------ERSMGFGRRLG------------------------------
--------------------------------------------------------RAVL
GS----------------------------------------------ID-HQSAGPGYH
TRDAELRK-----IHR---------------AAIQGDA----------------------
AE---VERCLARRS-RD--VD-AQ---------------------DRTVL----------
----------HLAC--AHGCVEVVTLLLSRKCQINI--CDRLNRMPLMK-----------
-AVHCQEETCSIILL-EHGANPNIKDVY----SN--TAVHD-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-----------------------------

------------------MKKIF---SKKG------------------------------
--------------------------------------------------------ESPL
GSFA----------------RRRRSSAGGGG----------------EPGDGAYSQPGYH
VRDRDLGK-----IHK---------------AASAGNV----------------------
AK---VQQILLLRK-NG--LN-DRDKM------------------NRTAL----------
----------HLAC--ANGHPEVVTLLVDRKCQLNV--CDNENRTALMK-----------
-AVQCQEEECATILL-EHGADPNLADVH----GN--TALHYAV-YNEDIPVATKLLLYDA
NIEAKNKD-D---LTPLL------LAINGKKQQMVE-FLIKKKAN--------VNAA---
-DKLES-------SH-QLISEY--KEER--IPKNSSQNSNSVDESSED------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------SLSRLSG--KPGV--------------D----D--SWPTSDD---------
--------EDLNFDTKN-------------------VPKPSLAKLMTASQQSRK---NLE
ATYGIVTT------------------GSRTLFEDRDSDSQ--------------------
---------------------D-------------------EVVV---------------
------------------------------------------------------------
-----------------------------ESLPT--------------------------
----------------------------------TSVKAQGFSHPT--CQSPDPLP-KPS
HKS---------------------------------------------------------
----------------------------------------LANP----------------
-----------------------------------GLIKEEPTKPAVGEKE---------
---NGIDIIE----SAPLE--------------QTNNDN-------------LTYVDEVH
KNN----RSDMMSALGLGQEEDIESPWDSESI-SENFPQKYVD---------------PL
AGAADRKEKNIGNE---Q------AED----------------------------MFYIP
SCMSGSRNFKMAKLEDTRNV--------------GMPVAHMESPERYLHLKPT----IEM
-KDSVPNK-----------------------------AGGTK------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------DV------------------
---------------------------------------------QTSK-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------AA
GHDLEVASEEEQER-EE-------------SENHQPQVE--------EERKKHR------
---------------------------NSEMEVS---ANIHDGATDDD------------
-----EDDGLIQ---------ERRNGETD----HQQFPRKENKEY---------------
---------ASSGPALQMKE-VKR--------TSKESVNSPVFEKASLL-----------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------TGGLLQVDDDSSLSE-
-------------------IDEDEE---RPSKKTSNEKNK---VKNQIQSMD--------
------------------------------------------------------DV-DDL
TQSSETASEDCELP--RSSYKNFMLLIEQLG---ME--CKD--SVSLLKIQDA----ALS
CERLLEL---KKNH-------------------CELLTVKIKKMEDK-------------
--VNVLQ----KELSETK---EIKSQLEHQKVE-WEREL--CSLRFSLNQEEEKRRNADM
LY-EKIREQ----LRRKEEQ------------------YRKEVEVKQQLELSLQTLEMEL
RTVKSNLN-QVVQERNDTQRQLSREQNARMLQDGIL-----TNHLSK--QKEIEMTQ---
-RKMNSENSH-----SHEEEKD---LLHK------NSMLQEEIAMLRLEIDTIKNQNQEK
EKKCFEDLEIVKEKNEDLQKTIKQNEETLT--------QTISQYNGRLSVL-T------A
ENAMLNSK-----------------------------------LESEKQSK---------
--ERLEAEVESYRSRLAAAIHDR--DQSETSKRDLE----LAFQRARDEWSRLQDKMNFD
ASNLKDNNEILS--------------------------Q-QLFKTESKLNS--LEIELHH
TR-DALREKTLG-LER--VQKDL--SQTQCQMKE-----IEQKYQN-EQVKV------NK
YIGKQESVEERLSQLQSENMLLRQQLDDAHNKA---DNKEKTVINIQD----QFHAIVQK
LQAES-EKQSLLLEERNKELISEC-NHLKERQYQYENEKAEREV--VVRQLQQELADT--
--LKKQ------SMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQ-LQEAQDRHTEAVR
C-----------------------------------AEKMQDHKQKLEKDNAKLKVTIKK
QMDKIEELQ----KNLLNA-----------------------------------------
------------------------------NLSEDEKE-QLKKL---MELKQSLECN-LD
QEMKKNVELEREITGFKNL-----LKMTR--------------KKLNE------YENG--
--EF-SFHGDLKSSQCEMDIQINKLKHKIDDLTAELETAGSKCLHLDTK-----------
-NQVL--QQELLSMKTIQKKCEKLQKNKKKLEQEVINLRSH---IER-NMVELGQVKQY-
KQEIEERARQEI-VEKLKEVNL---FLQAQAA-SQENLEQ-LREN-NFASMKSQMELRIK
DLESEL-SKIKTSQE------DFNKTELEKYK----QLYLEELKVRKSLS-NKLNKTNER
LAEVSTKLLVEKQQ---SRSLFT------TLTTRPVMEPPCVGNLNNSLDHNRKLIPREN
LVI-SSSNPRTSNNS-VENYLSKMQQELEKNITRELKEA-AAE-----LES-----G---
--------------------S-IASPLGST---------DES----NVNQDLVWKASREY
VQVLKKN--YMI------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

----------------MKKILVHG----VK------------------------------
---------------------------------------------------------EKT
PMGF--------------CDVPRKNLLDFLR--------------DM-----KSISVPNE
PRYKPLRK-----IHQ---------------AASDGDT----------------------
ER---LQRMISLG-KHS--VH-DRDFK------------------ERTAL----------
----------HFAC--ACGQVEVVSILLRNNCDIDA--ADMNFITPLMK-----------
-AVQNWTYECVCILL-KHGADPNRKDKN----GN--TSLHYAV-SEDNQTLAKCLLKYSA
NMEQKNKD-G---FTPLL------LALKENKIEMAK-FLVKMGAN--------IHVF---
-DDMRR-------NT-LLYAIR--WDSK--DMVNL-------------------------
--LL-DEG-IDF--------FFRD------VFG-WTALR---YA-IE---GTS---K---
-GSREILMNYDEMLRRKNKDGIPEYKFLEDK---------------------SLDKHPN-
DPTSGSTFPKSNENACKFDDEPDI------SKYVLATCPNNMHRAEEEGDKSETKKAADV
Q------VWTNPTL----------KSSTKGKV-----PNLNEVGTMTESHHFIK------
------ESDLEI-----------------------------ESLVETFSYDNEDKQ--SV
--------SDDGHFSG--TTPK-----------WCQN---DT--NRKTTVQD--CMYP--
-----------NLKSST------------------EGKIPTR-NKAGKMAESA-------
-------------HFIIESDLEIESLEETVSCDSE-----DK------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------QLLV----------------------------------------------
------------------------------------------------------------
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-----------------------------

--------------------------MFDD------------------------------
--------------------------------------------------------YEPE
RWPT--------------LR--------------------------ERLCSDGFSFPEYR
IKLSHLRR-----IHR---------------AIFYGRL----------------------
EK---LEYLLLTRS--D--VNKR-DKK------------------ERTPL----------
----------HLAC--ATGQPDMVSLLVSARCELNL--YDRECRTPLIK-----------
-AVQLRQEVCATILL-KNGADPNIMDFF----GR--TALHYAV-YNEDTSMIETLLFYGT
DIEECSKY-E---YQPLL------LAVSRAKVNMVE-FLLKKNAN--------VNAV---
-DFLNR-------SA-LILAVT--LGEK--DIVILLL-----------------------
---K-QHN-IDV--------FSRD------AYG-KTAED---YA-IE---TRN---KV--
--IFRLISEYKREKTSEELPINS-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------N--------------
----------PV--SS--Q-------------------------KQP-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------ALKV
IKISF-------------------------------------------------------
-------------IF---------------------------------------------
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-----------------------------

------------------MKSFFGLRSLRS------------------------------
--------------------------------------------------------TSSP
RVDG---------------------------------------------GREGGAQPGYR
IRGRELGK-----IHR---------------AASAGDV----------------------
AR---VQQVLLLGK-NG--LN-DRDKM------------------NRTAL----------
----------HLAC--ANGHLEVVTLLVERKCQLNL--CDSENRTALIK-----------
-AVQCQQEECAAILL-EHGADPNLKDTR----GN--TALHYAA-SGQSVSIAAKLLSYSA
DIEAKNQD-G---FTPLL------LAVSKNNQQMVE-FLINKGAN--------VHAL---
-DASKS-------NH-KLISEY--LTEK--MTNFSSQNNNQXXXXXX-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------XXXXXLFR--VPDT--------------D----D--SWSSSD----------
--------DDLNSELKI-------------------VQNPDFSKQTSVTHQFKE---KFE
ANCYIVKA------------------ENRALFTDSHSAGG--------------------
---------------------N-------------------DDGI---------------
------------------------------------------------------------
-----------------------------ETPVK--------------------------
----------------------------------PS--IQEISHPD--ISSPLHFPKSSK
P-----------------------------------------------------------
----------------------------------------LAVC----------------
-----------------------------------HLANEETAKEACRNEK---------
---SGSHITD----SASAQ--------------QTNHDN-------------LTCADEEH
KSS----RYDMNPALGFGEEEDTESSCESQNV-CKNAAQMHIG---------------HL
SGSVDERGKHILNQ---Q------KYD----------------------------VFYIP
SCMSGSRSVKMSKLEDARNV--------------GIPVAHMDYPRQYPRLKPL----VEV
-RASASPK-----------------------------TAKTK------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------GGQT----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------PQ
PVKCEMTSEKDQENREE-------------SANDYLQV---------EEGKTYK------
---------------------------SGEVEVS---ENMCDAA----------------
-------DQLIQ---------QRQKEPMD----NQLFPIVENEDS---------------
---------DSSGPSLYIKE-GKEKER--KTPPPADFMIMPVIDESDSL-----------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------TCSELQVTDDDSLGE-
-------------------IAKNSG------------------AKRQIKPAD--------
------------------------------------------------------VL-DFL
TQSSETASEDSELP--YSNYRNAIFLTEQLG---LG--GKD--SVNVSKKGET----LLF
YKRLLEL---NRYH-------------------YELLAQKNERRKAK-------------
--VSGLL----KLLSESK---EIQSQLKHQKEE-WEQEL--YTVRSTLKKEEEKRRTTDL
LC-EELRQQ----LRKTIGQ------------------NSKEVEVRQQLELTLQSLNREL
SALRNELN-QVTEERDDSQRQLAVEQNARALQERIA-----KDHYSR--QKDLEESY---
-KKVKSMVSE-----GGKKEKD---LLHK------NHMLQDRVSILKQELRKLSHQGQEK
ERKYFEDIKVLQEKNHALQDTIEQNEEAST--------EKIIQYTRQLDAL-K------A
ENITLNTT-----------------------------------LEDEKQNK---------
--ARLETEVESYCSRLAAVLCNQ--DPSQTSRNDLE----VTFQRAKDEWLNLQDHLTFQ
VSSLKASNKILS--------------------------Q-QLFKAESKSNS--LETELQH
TG-DALRQKTST-VEC--LQKEL--CRIHCQKKE-----LEREYDN-QQNLL------NE
HIRKQESLEGQLSEIQNENVLLQCQLDAAHSKA---SKKEKTVMSIHD----GFWDVKRR
NQAEP-EDQCLTQEERNKELINEC-NCSKQTVCPCENEKAQREE--LVRKLEQELAGS--
--RKKQ------STA----EVVSYYLIKLEDERRDFKKKVSQIRNQ--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------VDDLTSELQIASSKCLHLDAH-----------
-NQVL--QQEISYMTATRKKCGKLKKHNSELEQEIVNLKSH---IGK-MMEKYGQVEQS-
KRELEERSRHNL-AEILRAVEL---FLQKRAS-SPRYVEQ-RKEN-GTASMSNQVDLRVK
NLESEF-SKMKISHE------VSKEAEIEKCK----PLFIEEVKVKNSLE-NKPKXXXXX
XXXXXXXXXXXXXX---XXXXXX------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXX-XXXXXXXXXXX-XXXXXXXMEEALDVSTAGEVAEA-AAD-----SPE-----V---
---------------------SASFLLSST---------NKS----HETQDLLLKTSQEY
VDVLKKN--YMI------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TPL----------
----------HLAC--ANGYPHIVSALLEKRCNIHA--QDGENRSPLMM-----------
-AVKCQKEDCAVLLL-KHGADPNLTD-G----GN--TALHYAV-CGSVS--VEKLLKH--
ANLAQNRD-G---YSPLL------LAITEHNAEMVA-FLLKKGAD--------VNAS---
-DQSQR-------TA-LMIALS--EEPT--ILVNL-------------------------
--IL-QQD-VDL--------SRQD------ITDSQPRNM---LL-LM---ALL---CR--
--YHQLMANYGKGKQV--KK----------------------------------------
------------------------------------------------------------
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-----------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------SRTPL----------
----------HLAC--INGHADVVQFLVEKKCKLNP--RDKLNKSPLMK-----------
-AVEHQHRDCAAILL-EHGANPNHKGAS----GN--TALHLAV-MVSSKSLVDLLLEHGA
DIEAKNKL-G---YTPLA------LAITENCEEMAK-FLLQKGAD--------VNAQ---
-DNVFR------------------------------------------------------
------------------------------------------------------------
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-----------------------------

MVA-----EVGSMPAASSVKKPFGFRSM--------------------------------
-------------MPCRRGSGKSNVVASGDQDDSAVKTFRSKMAKWCCHCFPCCRGSGKS
NLGASGDQDDSAVKTVRS-----------------SKSNVGAWEEYDD---SAFMEPRYH
VRREDLDK-----LHR---------------AAWWGKV----------------------
PR---KDLIVMLRD-TD--VN-KMDKQK------------------RTAL----------
----------HLAS--ANGNSEVVKLLLDRQCQLNV--LDNKNRTALTK-----------
-AVQCQEDECALMLL-EHGTDPNIPDEY----GN--TALHYAI-YDEDKLMAKALLLHGA
AIESKNKH-D---LTPLL------LGVHEQKQQVVK-FLIKKKAN--------LNAL---
-DGYGR-------YK-MLYTCC--TLWIA-SIVSL-------------------------
--LL-ESI-WTD-----------------------SHET---YA-VS---RFF---FF--
--I---------------------------------------------------------
------------------------------------------------------------
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-----------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------D---EYTSL------LAINRKKEQMVT-FLLKKKPDLTAID----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------NFGR---------------TALILAACN---G-----
------------------------------------------------------------
--------------------------------------------------------STGV
VFQL--------------------------------------------------------
-------------------------------------------LQHNVDV----------
-----CCRDISG------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------WTAEDH--------AIAYNF-----------QAI
RRLI-----SEYKA------------------------------------N---KR----
------------------------------------------------------------
------------------------------------------------------------
-------RK----------RLQN-R-------------NPEQDL----------K-----
---------------------------------------LISEGE----------QDRL-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------QGCENNQPQVAEKMRKC---RNKKM
EVSR--------------------------------------------------------
------------------------------Y-----------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------LHADDSDNDD-DDDEL-IQER----------
--RGR------K------------------------------------------------
------------------------------------------SD----------------
------------------------------------------------------------
---------------------------------DHQFP----------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------R
-------------------------------------------Q----------------
-------------------KREEY---NRLARKTSNEKNK--------------------
---------------------------------------------VKRDLYSKDDL-NDI
IWSPETSSEDDDLP--YSSDKNFMLFIEQHG---ME--HK--DFVSLLKIKNA----ITA
CERSIEH---KKCN-------------------CEQLKVKFQKMKNK-------------
--ISMLQ----KELSETD---KTKSQLEHQNLE-CKQKL--CNFSCILQEEEEKRRKAEE
LY-EKDTEE----LKIMEEQ------------------YRTQTEVKKQLQLTLKSLEVEL
KTVRSNSN----------------------------------------------------
----------E-SSHTHEKERD---LWQE------NHLMRDEIARLRLEIDTIKYQNQET
EKKYFKDIEIIKENNEDLEKTLKLNEETLT--------KTITRYSKELSAL--M-----D
ENTVLNLE-----------------------------------LEKEKQST---------
--QRLKTEMESYPCRLAAALHDH--DQCQSAKRDRQ----LAFQSTVNEWCHLQENINSH
-------IQILS--------------------------Q-QLSKVESTSSG--LETELHY
ER-EALKEKTLA-IEH--MQGVL--SRTQCQLKD-----IEHMYQN-DQPIF------EK
YVRKQQSVEDGLFQLQSRNLLYQQQCNDADKKA---DNQEKTIINIRA----KCEDTVEK
LQADC-RK----LEENNKELMKEC-TLLKERQCQYEKEKEEEEV--VMRQLQREVGDT--
--LNKQ------SLSEAMLEISSQCHHNLEDETRDSKKKLDQLRSQ-VCMKLRMSTVTL-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------MKKIF------K------------------------------
---------------------------------------------------------GHS
PW----------------------GFLSFRH--------------VS--A-ENQEPPRYL
TGYMPMKK-----IHK---------------AASVGDI----------------------
TE---VQRMLEFG-HVD--VN-ITDRK------------------KRTAL----------
----------HYAC--AHGQSEMVSLLLWYDCNIEA--RDCEDSTALIK-----------
-ATQRQHEECVKILL-DNGADSNAVDAY----QN--SALHYAV-YNNNLTIASKLLAFNA
DTEIKAKN-G---YTPLI------LAVLENKEEMVE-LLLQAAAD--------INAL---
-DNCKR-------SP-LIHAVR--AQFK--NMISL-------------------------
--LL-QQG-ADV--------SLVD------VYG-ATAQS---YT-VF---ETF---Q--N
TQP---------------------------------------------------------
GVVLR--RITLQK--IS-FI----------VKIV-FPH---FL-----------------
----------------------------------------L-SIHFVDLKYSFP------
------LSSEADT-------------------CPECYSKTRVSVLS-------DSRPHFL
--------------SP--QTPG-------------------I--QSPMFTES--NLWI--
-----------GYP--A------------------DWPEPIKFSRQPAVYNPI-------
-------------EW--MVKLALKSY----CF----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------FG-FVQDDLV----------SL------------------------LAPLEE
YKPQMK----EFS----------------------------------------------V
PEAAELQTDVKL---ERQGVL-------GYEEMGLETCQESN------------------
------------------------------------------------------------
--------LGK---------------------------------TW--------------
------------------------------------------------------------
----------------T-------------------------------------RTRKDE
CNFDTK--DKLKKHLLAQRAPSSQA-----------------------------------
------KP-SPAPLQLQEQ--AE--EPEMNAA------------------------SDGE
DTCGPSRSAEGQVLRGMSLEGEKLE---------------------SKDALQLVVNKLSQ
KP--GEICEA---------------VKIG-------------------------------
---VHHEEERPCDDWT-GKTPLKSASPKPAR-DSLGCEDR--------------------
--DA---AAAPVSVPLQTFPGWEEGGLGDVFSSPSSSQVVENSGQSVTKF-PLM----K-
-----NK--CENNKSE--------MEESLRKSKEKSS-----------------------
------------------------------------------------------------
----------KKPESGKADGTCPEV-C------MGENQGGREFKGQLQKT----------
--------------------------VKPKRMAWQLEIRHMPKSSEPK------------
--------G-LSDFKEKTQVSELK-------------------GWGD-STLP-DT----Y
KKSKGAWDFTQKPLHSKGK------------APPCT---------------LG---TARA
PPPAGRTASTFADEDLQD----SL-SDDEFHVLE-------------EEILAWEKVHLEN
ESVSEDL-LNKCEGISSD---------ATD----------PKRNDLE----------N-E
D----TGEDSD--FE-------------VTTQSEH---KSLDGSE-NSQL----------
---Q-V-CLSKTC------------PQTQNTFADPA-------RPTNPQSQKE----SK-
------------------------HRY------PPPL--------HLQKMSEDPEIN---
-------KKCDGECAPV----------HPEVPSARAHEKMSLARDVTGSNREPHRCSREL
--QHTVGDVSANICPDKEPLLGSYGGR-------TQFKVI---TCNLSNAV---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------LQMET---QVHQVNE----------
-------------------------------------------------------M-EEA
NSRSQ----------------------PSET---AS--GN---GDSPLELWDM----IHS
YERLLEL---KNSH-------------------EELFTGKLENMENE-------------
-----------REQTEMK---KIKSWLQHKGVE-GE-EL--CALR---------------
------------------------------------------------------------
------------------------------------------------------------
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-----------------------------

------------------MNKLFSFWKRKN------------------------------
--------------------------------------------------------ETR-
-------------------------------------------------------SQGYN
LREKDLKK-----LHR---------------AASVGDL----------------------
KK---LKEYLQIKK-YD--VN-MQDKK------------------YRTPL----------
----------HLAC--ANGHTDVVLFLIEQQCKINV--RDSENKSPLIK-----------
-AVQCQNEDCATILL-NFGADPDLRDIR----YN--TVLHYAV-CGQSLSLVEKLLEYEA
DLEAKNKD-G---YTPLL------VAVINNNPKMVK-FLLEKGAD--------VNAS---
-DNYQR-------TA-LILAVS--GEPP--CLVKL-------------------------
--LL-QQG-VEL--------CYEG------IVDSQLRNM---FI-SM---VLL---HR--
--YPQFTASHGKKKHA--K-----------------------------------------
------------------------------------------------------------
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-----------------------------

-------------------------------MKKRS------------------------
--------------------------------------------------------TARN
GWGL--------------LRFGFNLRPLRVRSP----------PMTMTVDSFHSPGPGYH
IRYQDLRG-----IHR---------------AVIEGDT-------------------EKM
QE---IQQLLVFG-LHD--LN-KRDRK------------------NRTAL----------
----------HLAC--AIGSVDMVKILVLSQCQLNL--RDGENRTALVK-----------
-AVQCQEEACVDILL-RKGADVNTKDFK----DN--TALHYAA-YEGNISIARKLLLNKG
DIEAKNKD-G---LTPLL------LAINEKKEKMVA-FLVEKA-N--------INAV---
-DYAKR-------TA-LHLACA--IGRED-------------------------------
--MV-KLL-VDR--------HCQL-------------------N-LC---DGE---DR--
------------------------------------------------------------
-------------------------------------------TA------L--------
--------V---------------KAIQ----------CQEE--------ACV-------
----------TLLL----------------------------EHGAD--PKVK-------
-DN---KGNTALHYAA--HEGI-----------VSIA---E---KLLL-QN----ANI--
-----------EAKNTD-------------------GLTPVLVAL-NENKEQM-------
------V------KFLVG-KGARLLSGDTVKSSDQLISEHEEEMK----------PEN--
------------------------------------------------------------
------------------------------------------------------------
-------------------------------SSQ--------------------------
---------------------------NHDLVAKKSEEVSLSSRTR--K---ADTDDSRP
SKHEDL---SSGT-----------------------------------------------
------------------------------------------------------------
--------------------------------------KEGATKLAIGKK------D---
---NGIDIIE----SPPQEQA---VNDNLT------------------------SADRAH
KNHMSD----RISALGRGE----DSSPW---D------SESISARLPKKSVD------CL
PGAADQQGQSIFSEQVEDS-----------------------------------------
---------------------------------PGKDL---------LHWKST----TKV
-KDSVPNE-----------------------------AVATSDKQTPRSDLSSEP-----
------------------------------------------------------------
--------------------------------------DLEV---------ASQQKQEQE
RPDKS-----------ENNHPQDKVIL---------------QTCILAE-KT------SE
S---QTKQINIPLVQLQ----NMAREPEMNMEC---DRHGD--RSVHSEHPRV---HKK-
--YE----EI-QMKQGKLDWKNNVKR-----------MSRELKQKIGKTCEKYQIITHPK
------------------LEQLRGNSKE--------------------------------
-----------------A--DVKEIPPNVTK-VTLDCEEK--------------------
--DEL---GVSVSVVPQAFPEQKEP--SLE---------NAILSHSYSGSPDYACQSSSK
LSSHENDNKPGEHVFNK--------NESLDSDPENKKLR--NPLV---------------
------------------------------------------------------------
--TFEVKEDQ-----------EFDMQMAK-------------------------------
--------------------------------------SLNQNTTNSK------------
-LDTGYIPP----------------------------------YSDP-ESLFDL------
--RLAHSNVAKQMIQKKRH----------DTSAIT--------------------NTYKK
TKPI----------------------------QD-------------SFQKPLDA-----
-----------------------------------------------------------D
N----D--STNNY---------------KTT----------EPAL-E-------------
----------------------------------NV-------S----SSPRPFRTSKVY
QKEELQQDMQNLQRFKNEKGMLQVELLA--LEKEKVE------------LQK--ETG---
---------------KE----------RKQHTSNKM------------------------
-------EGAENIYAA--------------------------------------------
-------------------------------AA----AAAPVLGTALAVA----------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------A---AAAPAAG-LIQQRKTGETDNHLFPT--
---------------------TQN------------------------------------
------------------------------------------------------------
-------------------------------------------EDS--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------DSNDPGLSIMEIKIKM---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------MKRIFTFASHKG------------------------------
--------------------------------------------------------ESPL
SGP--------------------------------------------EDGDRDKSRPGYR
IRDRDLGK-----IHR---------------AARVGEV----------------------
AR---VQQLLLLGK-SG--LN-DRDKM------------------DRTAL----------
----------HLAC--ASGHPEVVTLLVERKCLLNA--YDNENRTPLVK-----------
-AVQCQEEECATILL-EHGANPNLTDNF----GN--TALHYAV-CGQNRAIAEKLLLHGA
DTEARNKN-G---LTPLL------LAISENKEEMVE-ILVKKEAN--------TRAV---
-DEIHS-------NQ-QLISEY--KEEK--KCNMFE-NSNS-EDESSE------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------DCISRLSS--EPGT--------------D----D--PWPTSVE---------
--------EDLDFDTKN-------------------VPKPNLTKLLTASQQFRKNTSTM-
VKTETVKP------------------ENTALSDSSNSDGQ--------------------
---------------------N-------------------EDVV---------------
------------------------------------------------------------
-----------------------------QTCPA--------------------------
----------------------------------TAAKVQSVSHPT--LPSPEPLLKYSF
------------------------------------------------------------
--------------------------------------KSTAIP----------------
-----------------------------------ALKKEEMTRPEIGKKE---------
---NDIDT-E----SVPQE--------------QTNNDG-------------LSHIDEVH
KSN----RRDMMSALGFGEEEDIDSPWDSESI-SESPPHKSVDH----------------
SEATDQR-RKSIHE---E------VDD----------------------------VFYIP
SCISGSRNFKMAKLEDTRSV--------------GIPVGRMESPEKYSHLKPA----VEM
-KDSVPNK-----------------------------EIGMK------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------DV------------------
---------------------------------------------QTSR-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------SA
IFHNKVVTSCKKRDFVG-------------SRSNKKEYF--------EEEKKYQ------
---------------------------SKQVEVS---GNLSDGAAAPN------------
-----STDGLIQ---------QRRSGKTD----NQQIVIKENEEY---------------
---------EGYSPALHMEE-VK-NKN--ENWTSRESGTAPGFGKTSPP-----------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------TGGPLDLSDDYSWSD-
-------------------VDQGET--GRPAKKAANEKNK---VKNQRNSSD--------
------------------------------------------------------DR-DDI
SQSSETASEDYEWP--H--TKNSVLLIEQLA---VD--CKD--SVSLLKIQDA----VLS
YERLIEL---KKNR-------------------CRLLTAKIKKLENK-------------
--VSGLK----QELSELR---EVKSQLERQKVE-WEQEC--CSLRFTLKQEAEKRRNADI
LY-EKIKEQ----LRRKEEQ------------------YSKEVEVKGQLELSLRTLETEL
RTVKNSLN-QVMEERNDTQRQLSREQNARILQDGIL-----TSHLCK--QKELEMAR---
-KQMNSEVFD-----NREKEKD---LLCK------NHMLQDEIAMLKLEIDTIKSQNKEK
ENKYFEDIEIIKQKNDELQKTIKLNEETLT--------KTIFQYNGQLDVL-T------A
ENAMLNSK-----------------------------------LELEKQNK---------
--ERLETEVESYHTRLTAAIQDH--DQSQTSERDLK----LAFQRARDEWRCLQDKMNFE
VSNLKDSNEILS--------------------------Q-QLSKAEREFNS--LEIKLHH
TR-DALREKTLA-LEC--VQRDL--SHTQCQLKE-----MENMYQK-EQGKV------NK
YIGKQESVKERLSQLQSENMLLRQQLDDAQNKV---EGKEKTVISIQD----QFHDIVKQ
LQAES-EKQSHRLEDRNKELTSEC-NHLKERLYQYENEKTEREV--VVRQLQQELADT--
--LKKQ------SMSEASLEVITQYRINLEDETQNLKKKLDKVSNQ-LQEAQDRNTELVR
D-----------------------------------AEKMQDHLQKLESENSELKVTVKK
QAGKIEHLQ----KSLLCP-----------------------------------------
------------------------------SLSKDEKE-QLKEL---TELKQSLEYN-LG
EEMKKNGELEKEITEFKKL-----LTMTK--------------TKLNE------YENG--
--EF-HSHGDLKMSQLETAIENNMLKYKIDDLRAKLETASSKCLHLDTT-----------
-NQVL--KQQMLSMKAQQKKCEKLERNKRKLEQEVVNLRSL---MEM-NMVDRGQVEQY-
KREVEERARQDI-VDKLKEVNL---FLQAQAA-SQENLEQ-LRDS-NSASIRSQMELRIK
DLESEL-SKLRTAQE------DSNKTELEKYK----QFYLEELQVRKSLS-TELNKTKER
LAEIRTELLLEKQQ----RTLLS------TLTGRPVLEAPCVGNLNTSLVLSGSLIPKEN
FLI-PTSRPQPSTNS-MDDYLTKMRQELDKSITRELEKA-AAE-----FES-----Q---
--------------------PCQAAPVAPT---------ARS----NQTQDLLLKASQEY
VQILKKN--YML------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
--MTS---------------RGGEKRGGSEGSPKPTVSAMRKTPSV--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------GSVRSQEDQL-
----------SLSYRGDRWSSDSSWL--SDSAGSDSE--------H-------------V
EGAL--------------------------------------------------DQP---
-----QHDVRLEDLCELHRA--------------ARSGD-------VP-----GVERVLA
PGD-----------------------------------PGVNKRD-RKESLRHLIPKCKM
EQSPESLPLNNNPDWHPTNLTVSDKTCQKSKILNVDDQCPSVSPSMPENQSATKELGQMN
LTEQEKM----------N---------------------VSGNDSLH--DLC-QSQLPE-
----------------------NKESK---------------E------AEQDLELTSEE
E---QERLKGHENKQPQ----KMSQEPEMAKDSDRED------------------IPVYS
ILPHAQKSEEMWIEQDKLEWKNKLKL-----------VTNELKQRFGE------------
------IRETYKIP----------------------------------------------
----VCPEEEPLLDNSMRKTNVKDIPFNLTN-N-------------------------IP
GCVEEDASEVSVSVVFETFPEQNEPSLKSIIH---------PYSHPYSGSLEHACQSSSK
LHLHENKLDYDSDNKPGIEHIFSMDEN-FSNDAGIKKAR-NPEEVTVEMKE-----G---
QEF-DLQMTKNMNQNSDSC-----------------------------------------
---------------------------STNNYKSLKPKL-E--NL-SSLPPDSDRTSEVY
LHEELQ---QDMQKPKTEVDRVEEMF-----LALKKENVQLQKEVEEEVEKH---RSNST
ELSG-----------NPAHGAAAG------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------NNDDGL-NQQ-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------FPRKK-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------KKGH-DRPADKTSNEKNK---VKNQVH-----------
---------------------------------------------------PEADF-ADS
VGPSEMASEDCELS--HSTYENFLLLIEQLG---ME--CKD--SVSLSRIQDT----FCF
YEHLLKL---KNND-------------------YEQLTVKIKQTENT-------------
--VSVLQ----KELPETK---KTELQLELQKIE-LEKQL--YSLRLALKQEKEEKGNAVM
LY-NKYSEQ----LRLKEEE------------------CGKEVETKQRLKWTLRRLVKEL
KTVRNSLD-LVVQERNDVQKQLSEEQNARILQDQIL-----TS---K--QKELE------
--IAQKKMNSE-ISHRHKKEKD---LLHE------NCMLQEEIALLRLEIDTVNNQNQQK
EKKYFEDIEVVKEKNDNLQKIIKLNEEKLT--------ETILQYSGQLNDL-TA------
ENKILNSE-----------------------------------LENEKQNQ---------
--ERLEIEMESYRCRLAAALHDC--DQSQT-SRVPK----LDFQRTRQEWIHLQDKRKVD
MSDLQAKTEILS--------------------------E-KLSNAESKISS--LQIQLHN
TR-DAVERKSLI-LER--LQRDL--SQTHCEKKE-----IEQMYQT-EQRKL------KK
YIAKQESVEERLSQLQRENTLLPQQLDDAHKKA---NSQEKTISTIQD----QFHAFAKN
LQAES-EKKILSLQEKNKELMDEY-NHLQERMHQCEKEKAR RKV----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------DLIEAQETAPSRCLHLDAE-----------
-NEVLQLQQTLFSMKAIQKQCETLQKNKKQLKREVVNLKSY---MER-NMLECVEAEQH-
KLLIKEKAKKEI-AEKLNEAIL---TLQKQAAVSQEQLAQ-LRED-NTTSV KTQMELTIK
NLESEI-SRINTSSADF------NKTELERYK----ELYLEEVKVRESLS-NELNRTNEK
IAEVSAQLTVEKELTR---SPFA------ACSTRPILEPPCAGNLNDSEDLNRKHIPRKK
KSA---------PES-MESYLLKMQQKLQNDITTEVTAA-TKCEPEPYVAS-----P---
----------------------PESA-----------------YQKNLNQDPVLEATKEY
VQILSRK--YMI------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------MFPLNSQNLPPVSWHNYSQ-----------
-AVQCQQEECTSILL-EHGADPNLVDVK----GY--TALHYAA-FGPNISIAAKLLSYNA
NIEARDKD-D---LTPLL------LAVSENQQQMVE-FLLQKEAN--------IHAV---
-DKMKR-------TA-LILAVN--FASS--SVVRL-------------------------
--LL-EQG-VDI--------SPQD------CYG-RNAED---YA-VI---KGH---QM--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-----------------------------

------------------MRKLFSFGRRLG------------------------------
--------------------------------------------------------QALL
SS----------------------------------------------MD-QEYAGPGYD
IRDWELRK-----IHR---------------AAIKGDA----------------------
AE---VERCLTRRF-RD--LD-ARDRK------------------DRTVL----------
----------HLAC--AHGRVEVVTLLLHRRCQIDI--CDRLNRTPLMK-----------
-AVHGQEEACAILLL-ECGANPNIKDIY----GN--TALHYAV-YNKGTSLAERLLSHHA
NIEALNKE-G---NTPLL------FAINSRRQHMVE-FLLKNQAN--------IHAV---
-DNFKR-------TA-LILAVQ--HNLS--SIVTL-------------------------
--LL-QQN-IRI--------SSQD------MFG-QTAED---YA-FC---CDL---RS--
--IRQQILEHKNKMLKNHLRNDN-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------Q--------------
----------E----T--A-----------------------------------------
-------------------------------------------AM-------K-------
-----------------------------PAN----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
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-------------------------------------MKKRKERA---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------KAEQNLKVASEEKQERLER--SENKQPQDS---------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------QSYGKKKD---AMYG------NFMLKRDIAMLKEELYAIKNDSLRK
ENKYIQEIKSITEINAKFEKSVRLNEEMIT--------KKVAQYSQQLNDL-K------A
ENARLNSE-----------------------------------LEKEKHNK---------
--ERLEAEVESLHSNLATAINEY--NEIVER-KDLE----LVLRRADDVSR--HEKMGSN
ISKLTDKNELLT--------------------------E-QVHKARVKFNT--LKGKLRE
TR-DALREKTLA-LGS--VQLDL--RQAQHRIKE-----MKQMHPN-GEAKE------SQ
SIGKQNSLEERIRQRELENLLLERQ-LEDARKE---GDNKEIVINIHR----DCL-----
---EN-GKEDLL-EERNKELMKEY-NYLKEKLLQYEKEKAER EV--IVRECQEELVDH--
--LKKF------SNSESPLEGTSHCHINLDE-TWTSKKKLFQVEIQ-PEEKHEEFR----
------------------------------------------------------------
-------------K----------------------------------------------
-------------------------------------------L---FELISLLNYT-AD
QIRKKNRELEEEATGSKKC-----LEMTI--------------NMLNA------FANE--
--DF-SCHGDLNTDQLKMDILFKKLKQKFNDLVAEKEAVSSKCVNLAKD-----------
-NEVL--HQELLSMRKVQEKCEKLEKDKKMLEEEVLNLKTH---MEK-DMVELGKLQEY-
KSELDERAVQEI-EKLEEI------HLQKQAE-YEKQLEQ-LNKD-NTASL-K KKELTLK
DVECKF-SKMKTAYEE-----V--TTELEEFK----EAFAAALKANNSMS-KKLTKSDKK
IAVISTKLFTEKQR---MKYFLS------TLPTRPEPELPCVENLNSIE-LNRKYIPKTA
IRI-PTSNPQTSNNC--KNSLTEVLLC---------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------MKKLLTFRKR--------------------------------
--------------------------------------------------------TDVC
-------------------HSLSSDM-----CI----------GLASTS-SSLSVGANYN
LPDKHLKP-----LRK---------------PASVGDL----------------------
KM---LTMSLQLKK-PE--AN-MRGKG------------------HRTLL----------
----------HRAC--ANGNENMVTFLITKQYNINV--QDSENRTPLIK-----------
-AVQCQKENCASLLL-NHGADINRVDCN----CN--TALHYAV-CGESISLVKHLIENKA
NLEAKNKD-G---YTPLL------LAVAENNEKMVE-FLLKSGAD--------VNAS---
-DKNQS-------TA-LMIALS--IEPT--NLVSL-------------------------
--LL-QQD-LDL--------SCRD------IYG-FTAED---YA-SF---NGF---TM--
--YHQLIDNYGQQKKG--KKKSS-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------S--------------
----------ED--LT--S-----------------------------SM----------
------------------------------------------------------------
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-----------------------------

--------------TAFLMEKFFSWSVRKF------------------------------
--------------------------------------------------------ERKP
AWTV--------------TEFE-------------------------KKHLKRRPHFGYR
LLYWELGA-----IHR---------------AASTGNV----------------------
AA---VEKILGCRR-SG--VD-DVDHK------------------SRTAL----------
----------HWAC--AKGHQDMVAFLISRRCLLDP--QDKRAATPLIK-----------
-AVQCPAENCATLLL-DHGADPNIEDEI----GN--TALHYAA-YGGNTRMAEKLLSSNA
DIEKKNET-G---LTPLL------VAIQQNQETMVK-FLILQNAD--------VFAV---
-DNLNR-------TS-LMFAGW--YNTE--DIVHM-------------------------
--LL-ELG-VDV--------LSED------IAG-HSARD---YA-LQ-------------
------------------------------------------------------------
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-----------------------------

------------------------------------------------------------
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------------------------------------------------------------
-------ASSCLEG-RT--IT-YFFLL------------------HRTAL----------
----------HLAC--AAGYPDVVSFLVERHCKLDI--CDSNHRTPLMK-----------
-AVQCQQEECVSILL-LHGADPNMVDES----SS--SALHYAA-AGENLRIVERLLESKA
NMEARDKV----------------------------------------------------
------------------------------------------------------------
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-----------------------------

------------------------------------------------------------
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------------------------------------------------------------
----------------------------------------------RTAL----------
----------PWAC--ANGHAEVVTLLVDRKCQLDI--LDGENRTLLMK-----------
-ALQCQREACANILI-DSGADPNIVDVY----GN--TAVHYAV-YSENLSVVAKLLSCGA
DIEVKNKA-G---HTPLL------LAIRKRSEQIVE-LLLTKNAN--------ANAV---
-DKFKC-------TA-LMLAIC--HGSS--EIVGMVLQQN--------------------
---------VDI--------CAED------TCG-MTAEC---YA----------------
--------------------VAC-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------G--------------
----------FN--LI--H-------------------------QQLLEYKQ--------
-----------K------------------------------------------------
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--ISKNSQ----------------------------------------------------
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-----------------------------

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------------------------------------------MVAEVD------------
------------SMPAASSVKKPFGLR---------------------------------
--------------------------------------SKMGK--WCCHCFPCCRGSGKS
NV----------------------------------------------------------
----------------------------------GTSGDQDDSAMKTLRS----------
--K---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------MGKWCRHCFPCCRGSGK---------------
-------SNVGTSGDHDDSA-MKTLRSKMGKWCC-----------HCFPCCRGSGKSNVG
AWGDYDDSAFVEPRYHVR----REDLDKLHRAA-WWGKVP-----RKDLIVML-------
-------------------R--DTD--VNKKDKQKHG-FTPL--LLGVH------EQKQQ
VVKFLIKKKA----NLNALDR---------------------------------------
-YG---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-----------------------------

------------------------------------------------------------
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------------------------------------------------------------
-----------------------------------------------TSL----------
----------HLAC--ASGHPQVVNLLVERNCMIDP--TDKRNATPLIK-----------
-ATQCHEVECGSILL-MHGADPNHMDDG----GN--TALHYAA-YSENLDMAKQLLKYGA
DIEAKNKV----------------------------------------------------
------------------------------------------------------------
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-----------------------------

------------------MRKLFSFGRRLD------------------------------
--------------------------------------------------------QALL
SS----------------------------------------------RD-KEYAGRGYH
TLDWELRK-----IHR---------------AAIKGDA----------------------
AE---VERCLKRRF-WD--VD-ARDRK------------------DRTVL----------
----------HFAC--VHGHIEVVTLLLRRRCQIDI--YDRLNRTPLMK-----------
-AVHCQEEACAIILL-ERGANPNIKDIY----GN--TALHYAV-YNKGTSLAEKLLSHHA
NIEALNEE-G---NTPLL------FAINSRRQQMVE-FLLKNQAN--------IHAV---
-DNYRR-------TA-LMLAVQ--HNSS--SIVSL-------------------------
--LL-QQN-VNI--------FSQD------MFG-QTAED---YA-VC---CDL---RS--
--IQQQILEH--------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------K-----------------------------NK-------M-------
-----------------------------LK----------NHLR---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------N----------------------------------------------------
------------DNQETAA-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------VK-------------------------------------------PA-------
------------------------------------------------------------
-------------------------------------------------NL--K------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------K
------------------------------------------------------------
----------------------------RK-------EGAKA------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------EHNLKVISEEKQERLER--SENKQP------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
----------QDSQSY--QKSYL--KQAQHQIKE-----MKQMHPS-EEAKE------SH
SIGKQNSLEERIRQQELENLLLEQQ-LKDAYKE---GNNEEAVINIQE----DSL-----
---DN-GKEDLLLEEKNKELMNEY-NYLKEKLFQYEKEAA E-EV--IVRQLQEELADH--
--LKNF------PMSDSPLEGTSHCHINLDE-TRASKKKLFQVGSQ-PEGKREEFG----
------------------------------------------------------------
-------------K----------------------------------------------
-------------------------------------------L---FELI-SLEYN-VD
QIRKKNHELEEETTGYKKC-----LEMTI--------------NMLNV------FGNE--
--DF-SCHGDLNTDQLKMDILFKKLKQKFDDLMAEKEAVSSKCVNLAKD-----------
-NQVL--QQEFLSMRKIQEKCEKLEEDKKMLEEEVLTLKTH---MEN-NMVELGKAQEY-
KSELDEKTMQII-EKLEEI------HLQEQAQ-YEKQLEQ-LNKD-NTASL-NM KELTLK
DVECKF-SEMKTAYEE-----V--TTELEEYK----EAFAATLKANNSMS-KKIMKSNKK
IAMINTKLLMEKER---MKYFLS------TLPTRPHPELPCAENLNSTG-LNRKYIPKTP
IRI-PTSNPQTSNNC--KNSLTELLMCWALAP-----------------VY---------
FLL---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

MVA-----EVSSIPAASAVKKPFGLRSKMGKWC---------------------------
----------CHCFPCCRGSGKSNVGTSGDQDDSAMKTLRSKMAKWCHHCFPCCRGSGES
NVGPSGDQDDSAMKTHRSKMAKW-CCHCFPRCKGNGESNVEAWEDYDD---SAFMEPRYH
VRGEDLDK-----LHR---------------AAWWGKV----------------------
PR---KDLIVMLRD-TD--VN-KTDKQK------------------RTAL----------
----------HLAS--ANGNSEIVKLLLDRRCQLDV--LDNKKRTALIK-----------
-AVQCQEDECALMLL-EHGTDPNIPDEY----GN--TALHYAI-YNEDKLMAKALLLYGA
DIESKNKH-G---LTPLL------LGVRGQKQLVVK-FLIKKKAN--------LNAR---
-DRCGR-------NA-LILAVR--CGS-A-SIVSL-------------------------
--LL-EQN-INV--------SSKD------LSG-QMARD---YA-VS---SHH---NV--
--ICQLLSDYKEKQMLTISSEN--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------SNPEQ-----------
---------DLKLTSEE------------------ESQ------------RLK-------
--------------------------------GSENS-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------QPE--------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------EISQEQEINK-----------
---DCDREVE--------------------------------------------------
---------EVMKKHG--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----SNH------------------------------VRLP------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
----------------------------------ENLTNDATAGNGD-------------
--DGLNP----QSKSRTP---ESQ-----QFPD-TENEE--Y-HS---------------
------------------------------------------------------------
------------DEQNDTQKQVLEEQIAGMSQEEIL-----TN---K--QEQMEVAE---
-KEMNSEVSLS-----HKQEKD---LLHE------NCMLQEEIAMLKLEVDKIKQQSQLR
ERKLLEEIESVKAKNDKLLKAVKLREETIT--------KINI------------------
------------------------------------------------------------
------------------------------------------------------------
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-----------------------------

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---------------------------------------------------MV-------
---------------------------------AEHG-LTPL--------LLGVRGQKHQ
VVKFLIKKKA----NLSARDRCGRNALILAVHCGSASIVSLLLEQNIDISSKDLSGQTAR
EYAVSSHHNV-IC-QLLSDYKEKQMLTISSENSNPEQDLK---LTSEEESQR--------
-----------------------------------------------------------L
KGSE-------------NSQP---EEISQEQEINKD--CD--------------------
--REVE--------------------------------EVMK----KHGSNHVRLPENLT
NDATA-------------------------------------------------GNGDDG
LI-------------PQ---------------------SKSRTPESQQFPD---------
----TENEEYHSDEQNDTQKQVLEEQIAGMSQEEILT-----N-----KQEQME------
--VAEKEMNSE-VSLSHKKEKD---LLHE------NCXXXXXXXXXX-------------
----XXXXXXXXEKNDKLLKAVKLNEEALAKINIS-------------------------
------------------------------------------------------------
------------------------------------------------------------
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-----------------------------

MLEDTDH-------DAQTPN--A------S------------------------------
---------------------------------------------------------EQP
HWYW--------------RL--WTCCLGYGC--------------LD--YQ-VDEYPAYL
IPYEPVGQ-----FQR---------------AASMGDL----------------------
ST---VEHFITSR-RYH--VD-KCDRR------------------NRTSL----------
----------HYAC--AHNHPEVVTLLIESNCNINV--QDDEGCTPLIK-----------
-ATERNNLECVFILL-KHGADPHMADFT----GN--TALHYAV-YNGNKAIASELLEYKV
DINTTTKH-G---FTPFS------LAVFEKKEIMAE-FL---------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-----------------------------

------------------MRKLFSFGRGLG------------------------------
--------------------------------------------------------QALL
SS----------------------------------------------RD-KEYAGPGYH
TLDWELRK-----IHR---------------AAIKGDA----------------------
AE---VERCL-RRF-RD--VD-ARDRK------------------DRTVL----------
----------HLAC--AHGRVEVVTLLLSRSCQIDI--CDRLNRTPLMK-----------
-AVHCQEEACAIILL-EHGANPNIKDIY----GN--TALHYAV-YNKGTSLAEKLLSHHA
NIEALNEE-G---NTPLL------FAINSRRQQMVE-FLLKNQAN--------IHAV---
-DNFRR-------TA-LMLAVQ--HSSS--SIISL-------------------------
--LL-QQN-INI--------FSQD------MFG-QTAED---YA-VC---CDL---RS--
--IQQQIL---E------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------H--------------
------------------------------------------------------------
-------------K-----------------------------NK-------I-------
-----------------------------LK----------NHLR---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------N----------------------------------------------------
------------DNQ---------------------------------------------
------------------------------------------------------------
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-----------EHNLKVASEEKQERLER--SGNKQPQDS---------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------QSYGRKKD---VIYG------NYMLKRDIAMLKQELYTIKNDSLRK
EKEYIREIKSITEMNANFEKSVRLNDKMIT--------KTTAQYSQQLNEL-K------A
ENTRLNSK-----------------------------------LEKEKHSK---------
--ERLEVEVESLHSSLATAINEY--NEILER-KDLE----LVLWRADDVSV--HEKMDSN
ISQLTDKNELLT--------------------------K-QLSKARVKFNT--LKGKLHE
TR-DALREKTLA-LES--VQMDL--KQAQYRLKE-----MKQMHPN-EEAKE------SQ
SFGKQNSLEERIHQ-ELENLLLEQQ-LKDAYKE---GNNKEIVINIQE----DCL-----
---EN-GKEDLT-EEKNMELMNEY-NYLKEKLFQYEKDEAEG EV--IVRRLQEELADH--
--LNKF------SMSESPLEGTSHCHINLDD-TQASKKKLFQVGSQ-PEEKHEEFR----
------------------------------------------------------------
-------------K----------------------------------------------
-------------------------------------------L---FELRSSLDYN-VD
QIRKKNHKLEEETTGYKKC-----LEMTI--------------NMLNV------FGNE--
--DF-SCHGDLNTDQLKMDILFKKLKQKFDDLTAEKEAVSSKCVNLAKD-----------
-NQVL--QQEFLSMRKIQEKCEKLEEDKKMLEEEVLTLKTH---MEN-NMVELGKVQEY-
KSELDERTMQII-EKLEET------HLQEQAK-YEKQLEQ-LNKD-NIASL-NKKELTLT
DVECKF-SEMKTAYEE-----V--TTELAEYK----EAFAVALKANNSMS-KNLMKSNKK
IAVISTKLLMEKER---MKYFLS------TLPIRPDPELPCIENLNSIG-LNRKDISKTP
IGI-PTSNPQTSNNC--ENSLTEVEPDCVEQIIRETKKT-FAV-----LGT---------
CSHLLSSLESTEI-----------TPI-------------NKT---------GCS-----
GSQ-L-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

MVA-----EVCSKPAASAMKKPFGLRSK--------------------------------
------------------------------------------------------------
-------------------MGKW-CFPCFPCCRGSGKSNVGTWEDYGD---SAFKEPRYQ
VGREDLGK-----LHR---------------AAWWGKV----------------------
PR---ANLIVMLRS-TD--VN-KRDKQK------------------RTAL----------
----------HLAS--ASGNSEVVKLLLDRRCKLNA--FDSKKRTALIK-----------
-AVQCQEDECVLMLL-EHGTDPNLPDVY----GN--TALHYAV-YNEDKLLAKALLLYGA
DTEAKNKC-G---LTPLL------LGVHGQKQQMVK-FLIKKKAN--------LNAL---
-DKYGR-------TA-LILAVC--CGS-A-SIVSL-------------------------
--LL-EQD-IDV--------FSQD------TSG-KTATD---YA-VS---SHH---DI--
--ICQLLSDYKEKQMSKNSSEN--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------SHPEQ-----------
---------DLKLTSEK------------------EPQ------------RLT-------
--------------------------------RIETS-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------HPE--------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------KMSQEPEINR-----------
---DCDREVE--------------------------------------------------
---------EEMKKHG--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----SNN------------------------------VGLP------------------
------------------------------------------------------------
-----------------------------------------E-------NL---------
--------------------------------------------------TNG-------
------------------------------------AVA---------------------
---G---------NG---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------DDGGLI---------------------------P----
----R-------------------------------------------------RSRRKP
----------------------------------------ENQ-----------------
--QFPSTQ------------------------------------------------NE--
------------------E-----------------------------------------
----------------------------------------------------YH------
-SDEQNDTQRQ-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------L-----SE---E--QNQIEV-A---
-EKINSEISLS-----HKKEKD---LLHE------NHMLQEEIAMPKLELDTIKHQNQLR
ENKVLEDIESVKGKNDI-LKAIKLDKEE--------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

-------------------MKFFGFGGRRA------------------------------
--------------------------------------------------------QVVQ
ES----------------------------------------------ID-HVYTGSGYR
IRDADLRK-----IHR---------------AAVKGDA----------------------
AE---VERCLARRS-GD--LN-ARDKR------------------HRTAL----------
----------HLAC--ARGHVAVVTLLVDRKCQIDI--RDKLNRTPLIQ-----------
-AVHSQEETCASILL-KHGANPNLKDIY----GN--TALHYAV-YNDSTSLAEKLLSHDA
NIEALDKD-R---NTPLL------FAIICKREKMVQ-FLVKNQAN--------VHAA---
-NRLRR-------SA-LILAVH--HGLP--DIVNL-------------------------
--LL-QQN-VSI--------FFRD------MHG-RDVGD---YA-IS---CGS---KR--
--IQNQITEHKKKILEKDNPDAG-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------S--------------
----------SD--ES--L-------------------------VSIFQDL---------
------------------------------------------------------------
--------------------------------------------Y---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------V----------------------------------------------------
------------DSHTKPE-----------------------------------------
------------------------------------------------------------
----------------------------------------------------------DE
-GLTVTTK--------------------------------------------Q-------
------------------------------------------------------------
-------------------------------------------------CV--PEKVSEP
LPGPS-------------------------------------------------------
-------------DDKGNS-------------------------------------VVNG
K-K---------------------------------------------------------
------------------------------------------------------------
-------------------GPPAKQLSGKPT-T---------------------------
---------------------------------------------------EREDPAVKE
------------------------------------------------------------
----------------------------VV-------QKKNEQTS---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------RAGQDFLVDSEEEQESLEI--SEKKEPEVEEGKNTNKSEEIQL--SEN---
------------------------------------------------------------
------------TWDST-------------------------------------------
--------------------------------------------SS--------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------DATVE-LTQQTKIRKTSPQQFPKD-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------V-----------------------------------------------------
-------------------------------------KE--EHDRCTLKQENEEKSNVNM
LY-KNLTEG----LERKWEQ------------------YEKEVK-QQ-LKLTVRSLEMEP
KTLRNIP-----------------------------------------------------
---------NQ-DFHNHEEMK---DLMHE------NGILKRDIAMLREEICTLKNDSLEK
ENKYFKDFEIIEEINTGFENRNKLSEEMIT--------KIVSQCLQQLNDL-R------A
ENTRLNSE-----------------------------------LGKEREDE---------
--ERLEAEIESYQSRLAAAIREH--NQRVKTERDLK----LSLQRTQDISL--QRNTN--
-SELKDKYEFLK--------------------------E-KLSKTQIKFNT--LKDKVCK
TS-DTLREKTLA-LET--AQNDL--SQTQQQIKE-----MKEMYQN-ADAKV------SK
STGEWNYVEERLCELQRKNLWLKQQ-LDDAYQK---GDNEERVINIQG----GFI-----
---ES-GKKGLLLEEKNKKLMNEC-NHLKERLFQHEKEKAEV----SIKEDKYFQTFG--
--KNI-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------MKKIF---SKKG------------------------------
--------------------------------------------------------ESPL
GSFA----------------RRRRSSAGSGG----------------EPGEGAYSQPGYH
VRDRDLGK-----IHK---------------AATAGNV----------------------
AK---VQQILLLRK-NG--LN-DRDKM------------------NRQAL----------
----------HLAC--ANGHPEVVTLLVDRKCQLNV--CDNENRTALMK-----------
-AVQCQEEECATILL-EHGADPNLADVH----GN--TALHYAI-YNEDIPVATKLLLYDA
NIEAKNKD-D---LTPLL------LAVNGKKQQMVE-FLIKKKAN--------VNAV---
-DKLES-------SH-QLISEY--KEER--IPKNSSQNSNSGKTSDMYLST-LFYLFIYF
IIII-IIT-KSC--------TVAQ------A-----------------------------
-----GVQ----RHDLSSL-QPP-------------------------------------
LPG---------------------------------------------------------
---------------------------------------------------FT-------
-------Q----------------------------------------------------
FSCLCLPSSCDHRLSG--KPGV--------------D----D--SWPTSDD---------
--------EDLNFDTKN-------------------VPKPSLAKLMTASQQSRK---NLE
ATYGIVRT------------------GSRTLFEDRDSDSQ--------------------
---------------------D-------------------EVVV---------------
------------------------------------------------------------
-----------------------------ESLPT--------------------------
----------------------------------TSVKAQGFSHPT--CQSPDPLP-KPS
HKS---------------------------------------------------------
----------------------------------------LANP----------------
-----------------------------------GLIKEGPTKPAVGKKE---------
---NGIDIIE----SAPLE--------------QTNNDN-------------LTYVDEVH
KNN----RSDMMSALGLGQEEDIESPWDSESI-SENFPQKYVD---------------PL
AGAAYRKEKNIGNE---Q------AE----------------------------------
-----------------------------------------ESPERYLHLKPA----IEM
-KDSVPNK-----------------------------AGGMK------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------DV------------------
---------------------------------------------QTSK-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------AA
EHDLEVASEEEQER-EE-------------SENHQPQVE--------EERKKHR------
---------------------------NSEMEIS---ANIHDGATDDD------------
-----EDDGLIQ---------ERRSGETD----HQQFPRKENKEY---------------
---------ASSGPALQMKE-VKR--------TAKESVNSPVFEKAGLL-----------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------TGGLLQV---------
--------------------------------------------KNQIQSMD--------
------------------------------------------------------DV-DDL
TQSSETASEDCELP--RSSYKNFMLLIEQLG---ME--CKD--SVSLLKIQDA----ALS
CERLLEL---KKNH-------------------CELLTVKIKKMEDK-------------
--VNVLQ----KELSETK---EIKSQLEHQKVE-WEREL--CSLRFSLNQEEEKRRNADM
LY-EKIREQ----LRRKEEQ------------------YRKEVEVKQQLELSLQTLEMEL
RTVKSNLN-QVVQERNDTQRQLSREQNARMLQDGIL-----TNHLSK--QKEIEMTQ---
-RKMNSENSH-----SHEEEKD---LLHK------NSMLQEEIAMLRLEIDTIKNQNQEK
EKKCFEDLEIVKEKNEDLQKTIKQNEETLT--------QTISQYNGRLSVL-T------A
ENAMLNSK-----------------------------------LESEKQSK---------
--ERLEAEVESYRSRLAAAIHDR--DQSETSKRDLE----LACQRARDEWSRLQDKMNFD
ASHLKDNNEILS--------------------------Q-QLFKTESKLNS--LEIELHH
TR-DALREKTLG-LER--VQKDL--SQTQCQMKE-----MEQKYQN-EQVKV------NK
YIGKQESVEERLSQLQSENMLLRQQLDDAHNKA---DNKEKTVINIQD----QFHAIVQK
LQAES-EKQSLLLEERNKELISEC-NHLKERQYQYENEKAER EV--VVRQLQQELADT--
--LKKQ------SMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQ-LQEAQDRHTEAVR
C-----------------------------------AEKMQDHKQKLEKDNAKLKVTIKK
QMDKIEELQ----KNLLNA-----------------------------------------
------------------------------NLSEDEKE-QLKKL---MELKQSLECN-LD
QEMKKNVELEREITGFKNL-----LKMTR--------------KKLNE------YENG--
--EL-SFHGDLKSSQFEMDIQINKLKHKIDDLTAELETAGSKCLHLDTK-----------
-NQVL--QQELLSMKTIQKKCEKLQKNKKKLEQEVINLRSH---IER-NMVELGQVKQY-
KQEIEERARQEI-VEKLKEVNL---FLQAQAA-SQENLEQ-LREN-NFASM KSQMELRIK
DLESEL-SKIKTSQE------DFNKTELEKYK----QLYLDELKVRKSLS-NKLNKTNER
LAEVSTKLLVEKQQ---SRSLFT------TLTTRPVMEPPCVGNLSNSLDHNRKLIPREN
LVI-SSSNPRTSNNS-VENYLSKMQQELEKNITRELEEA-AAE-----LES-----G---
--------------------S-IASPLGST---------DES----NLNQDLVWKASREY
VQVLKKN--YMI------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------MKKIFGFGSKKG------------------------------
--------------------------------------------------------ESPL
GSSI----------------SPGRDG-----------------------GHRINFQPGYR
IRDKDLGK-----IHK---------------AAIVGNV----------------------
AK---VQQILLLGK-NG--LN-DRDKM------------------NRTAL----------
----------HLAC--ANGHSAVVTLLLERKCLLNL--CDSENRTALMK-----------
-AVECQEEECATLLL-EHGADPNVMDVS----GN--TALHYAV-LCQNISLAAKLLSYDA
NIEARNKD-D---LTPLS------LAISERKQQMVE-FLAKKEAN--------IHAV---
-DKMQS-------IR-QLISEY--KEKL--IVGKHS--YLFVEDESSEE-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------DSLSRFSN--KPGV--------------D-------SWPTSDD---------
--------EDLDLETKN-------------------VLKPNLTKLMNASQQSKRNSKLLE
AKCGIVSP------------------ESTAFSEDNNSDGE--------------------
---------------------I-------------------EDVV---------------
------------------------------------------------------------
-----------------------------ETIPE--------------------------
----------------------------------PSPGVRGFSHPA--FPSPDSITEMPQ
QFA---------------------------------------------------------
-------------------------------SSPLWSIACRKSM----------------
-----------------------------------TPNKEGATKPEIVDKE---------
---SDTDIVE----RAPQE--------------QINHDL-------------LSSVDGTH
KNN----RS------GLGEEEDIESPWDSEKC-KQSSDVSLWSD--------------VP
FLQRKSPVRCVRKE---S------NKN----------------------------VSYIP
SCMIGSRNFKMAKLEEPRHV--------------GIPVAHMVSDQKSVSIHRI----WTD
-DCNSHMT-----------------------------DKSIK------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------IILT----------------
--------------------------------------------NHTDL-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------SA
ELDLEMTSEEEEEKPVG-------------DNKQYKTNF--------KNKKFNN------
---------------------------KYMYSLP---NANLSIHLI--------------
-----NSFGNLS---------D-SRLQNF----IISFGAIKSGH----------------
---------LCSDPGMHRME-VKKKDT--SKWTPEECVIAPIFEKTDSL-----------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------TGGLLHVNDDSVLSE-
-------------------VDQDDDR-KKPAKKTSNENNK---VKEQINSVD--------
------------------------------------------------------DL-DDL
TQSSETASEDGELL--Y--YKNSMLLIEQLD---TA--CKD--SVSLLKIRDT----ILS
YERLVEL---KKSH-------------------CELLRGKIKKMERK-------------
--VRGLQ----KELSETK---QVKSQLEHQKVE-WEREL--GSLRFTLKQEEEQRRSADM
LY-EKMREQ----LRRKEDQ------------------YSKEVEMKQQLELTLRALEMEL
KTVRNDLD-QVTEERNDTQKQLSRERSARILQDGIL-----ANHLAK--QKEIEMAN---
-KEVNSEVSV-----SCEEAKD---LLRK------NHMLQDEIAMLRLEIDAVKIQNQEK
EKKYFEDLEIVKGKNDDLQKAIKLNEETLT--------KTISQYTGQLSAL-T------A
ENTMLNSK-----------------------------------LENEKESK---------
--QRLETEVESYRSRLAAASHDH--DQCQTSKRDLE----LAFQRARDEWFCLQDKMKSD
MANLRDNSETLS--------------------------Q-QLSRAESKFNN--LEIKLHH
TR-DSLREKTLM-LER--VQRDL--SQAECQKQE-----IEHMYQN-EQGKV------NK
YIGKQESLEERLSQLQSENMLLRQQLDDAQNRA---DSKEKTIISIQD----QFQQIVKK
LQAER-EKQVLMLEERNKELIKEC-IHLKERMCQYENEKAERDVEKAVRQLQQELADT--
--LKKQ------SMSEASLEVLSRYRANLEVEAQDLKKKLCQLTSQKLQEAQDQLTEAVR
C-----------------------------------AEKTQDHVQKLEIENAELQTTVKK
QEGKIEQLQ----KNLLST-----------------------------------------
------------------------------RSSEDEKE-QLKKY---IE-----ENS-LY
QEKKKNSELEKEITGFKKL-----LKMSR--------------RKLNE------YENG--
--EL-SFHGDLKTSQTEMDIQINMLKHKCEERLIILETASSKCLHLDAK-----------
-NQVL--REELLSMKGMQKKCEKLEKNKKKLEQEVVNLRSH---IEM-NMVERSQVEQY-
KREIEERARQDL-VEKLKEVNL---FLQIQAA-SQENLEQ-LQEK-NNASIRSQMELRIK
DLESEL-SKVKTLQE------ESHKAELEKYK----QLYLVELEVRKSLE-GKLDKTHER
LAVISTKLEVEKEQ---NKSLLS------TLTTRPVLEPPCVGNFNNPLVLNGNLTPRAN
VGF-STSIPRPSNNS-METYLTKMRQELDRSITRELREG-IAN-----EKF-----Y---
--LL---PSG---------KAPKLSPLGAT---------DGS----NLSQDLLLKTSQEY
VQILKKK--YMI------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

MKEDIDY-------DAHTIK--G------P------------------------------
---------------------------------------------------------KRA
RWYT--------------CL--WPACLGRGC--------------LS--SK-RQEFPLYS
IGYDPVGQ-----LQR---------------AASVGDV----------------------
AS---VGRLIKFY-GFH--VN-QCDSR------------------HRTSL----------
----------HYAC--AHNHPDVVRLLLSYNANIDV--LDDEGCTPLIK-----------
-AAQRDNVECVSILL-TQDADPHVMDFS----GN--TALHHAV-SRGNTAIASNLLECNA
DIDGKTEY-G---LTPYK------LALFENQHQMAE-FL---------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
-----------------------------

------------------MRRFIGLGGKQG------------------------------
--------------------------------------------------------QCSG
A------------------------------KV---------------GIKRTSTRCEYK
VQDWKLEK-----IHK---------------AALAGDV----------------------
VK---VQQILPKGK--A--LN-YPDKK------------------NRTAL----------
----------HLAC--ASGRQELVTLLAERKCELYI--RDGRGKTALIM-----------
-AVQCQEEKCANILL-EHGADPKAADVN----GN--TALHYAA-HHGMISIAEKLLSLSV
NVDVKSK-----------------------------------------------------
------------------------------------------------------------
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-----------------------------

------------------MNKLFSFWKRKN------------------------------
--------------------------------------------------------ETR-
-------------------------------------------------------SQGYN
LREKDLKK-----LHR---------------AASVGDL----------------------
KK---LKEYLQLKK-YD--VN-MQDKK------------------YRTPL----------
----------HLAC--ANGHRDVVLFLIEQQCKINI--RDSENKSPLIK-----------
-AVQCQNEDCATILL-NCGADPNLRDVR----YN--TALHYAV-CGQSFSLVEQLLDYEA
DLEAKNKD-G---YTPLL------VAVINNNPKMVK-FLLEKGAD--------VNAS---
-DNYQR-------TA-LILAVS--GEPT--RLVKL-------------------------
--LL-QQG-I--------------------FVDSQLRNM---LI-SM---VLL---YI--
--HNSLQVMERRNMLN--RHLIL-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------G--------------
----------TA--CD--------------------------------------------
------------------------------------------------------------
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-----------------------------

-----------------TMQMLFH----KK------------------------------
---------------------------------------------------------QRT
PLGF--------------CDGLDNVFVGFGS--------------KD--E-KGCRPPKYH
ASYAPYYP-----IHK---------------AASMGDV----------------------
NT---VKSFVERG-VFA--ME-QTDWK------------------YRTAL----------
----------HFAC--VYGHPEVVTLLVESSCEISP--KDIKDATPLIK-----------
-ASQCRQTECLNILL-KHGADPNIMDCS----DN--TALHYAV-YNGDIETATKLLEYKA
NIEAINEN-K---ITPLL------LALKQNKEKMAE-FLIHNGAN--------AKTC---
-DFLGR-------SS-LMYAVR--CGSE--LIIKL-------------------------
--LL-QRD-IDT--------FKQD------VFG-WTAKR---YA-VE---SKS---R---
VSTRKLLIDYDEEELRQRCSGNQLYKFFNPK--ILSK-----------------------
------------------------------------------------------------
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-----------------------------

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-------G-E---HTSLL------LAVNRKKEQMVA-FLLKKKPDLTAID----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------NFGR---------------TALILAARN---G-----
------------------------------------------------------------
--------------------------------------------------------STSI
VYQL--------------------------------------------------------
-------------------------------------------LQHNIDV----------
-----FCQDTSG------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------WTAEDY--------AVASKF-----------QAI
RGLI-----SEYKA------------------------------------N---KR----
------------------------------------------------------------
------------------------------------------------------------
-------HK----------SLQN-S-------------DPEQDL----------E-----
---------------------------------------MTSEGR----------QERL-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------EGCESSQPQVEEKMKKC---RNKKT
EVSR--------------------------------------------------------
------------------------------N-----------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------VHADDSDNYNDDVDEL-IHKI----------
--KNR------K------------------------------------------------
------------------------------------------PG----------------
------------------------------------------------------------
---------------------------------NHQFP----------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------E
-------------------------------------------E----------------
-------------------ENDEF---DRLARKTFNEKSK--------------------
---------------------------------------------VKSQIYFRDDL-NDI
SESSEKTSEDDELP--YSDDKNFMLLIEQRG---MD--CK--DFVSLLKIKDA----TAA
CERSIED---KKCY-------------------CERLKVKFQKMKNN-------------
--ISVLQ----KVLSETD---KTKSQLEHQNLE-RKKKL--CNLRFILQEEEEERIKAEE
LF-EKDTEE----LKITEEQ------------------YVTQTEVK-QLKLALKSLEVEL
KTVRSNSN----------------------------------------------------
----------Q-TSHTHEKERD---LWQE------NHLIGDEIARLGLEIDTIKHQNQET
ENKYFKNIEIIKENNEDLEKTLKLDEETLT--------KTITRYSKELNVL--M-----D
ENTMLNFE-----------------------------------LEKEKQSK---------
--SRLETEMESYRCGLAAALCDH--DQCQSSKRDLQ----LAFQSTVNEWCHLLENRYSH
-------IQILS--------------------------Q-QLSKAESTSSG--LETELRY
ER-EALKEKTLG-IEH--VQGVL--SRTQCRLKD-----IEHMYQN-DQRIW------EK
YVRKQQSVEDGLFQLQSQNLLIQQQCNDAHKKA---DNWEKTVINIQA----KCEDTVEE
LQAEC-RK----LEENNKGLMKEC-TLLKERQCQYEKEKEEGEV--VVRQLQREVGDA--
--LNKQ------LLSEAMLEISSQHRVNLEDETRNSKKKLGQMRSQ-VCMKLSMSTVTL-
------------------------------------------------------------
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-----------------------------

------------MGVGGSSLGT--------------------------------------
------------------------------------------------------------
-------------------CRGCMAHWRENR----------------S--KDGFSNPVYR
VRQKDLGM-----IHK---------------AAIAGDV----------------------
NK---VQESILLRL-ND--VN-DRDNK------------------NRTAL----------
----------HLAC--AHGHPGVVADLVVRKCQLNL--TDSENRTALIK-----------
-AVQCQEEVCASILL-EHGADPNVRDMY----GN--TALHYAI-DNGNISMAGKLLAYGA
DIEAKSQG-E---CTSLL------LAINRKKEEMVT-FLLKKKPD--------LTAI---
-DNFRR-------TAL-ILAAC--NGL-------------------TG----------VV
FQLL-QHN-VDV--------CCQD------ISG-WTAED---YA-VA---YNF---Q---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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----------------------------------------AIRR--------------LI
SEYK--------------------------------------------------------
------------------------------------------------------------
-----ANK-------------------------------RR-------------------
------------------------------------------------------------
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---------------------------------------------K---C----LQNRNP
EQDLKLISEGEQDRLQG-------------CENNQPQVA--------EKMRKCR------
---------------------------NKKMEVS---RNL--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------LARKTSNEKNK---VKRDLCSKD--------
------------------------------------------------------DL-NDM
IWSPETSSEDDDLP--YSNDKNFMLFIEQHG---ME--HKD--FVSLLKIKNA----IAA
CERSTEH---KKCN-------------------CEQLKVKFRKMKNK-------------
--ISMLQ----KELSETD---ETNSQLEHQNLE-CKQKL--CNFSCILQEEEEERRKAEE
LY-EKDTEE----LKIMEEQ------------------YRTQTEVKKQLQLTLESLEVEL
KTVRSNSK-ESS------------------------------------------------
--------------HTHEKERD---LWQE------NHLMRDEIARLRLETDTIKYQNQET
EKKYFKDIEIINENNEDLEKTLKLNEETL----------TITGYSKELNAL-M------D
ENTMLNLE-----------------------------------LEKEKQST---------
--QRLKTEMESYPCRLAAALCDH--DQCQSAKRDRQ----LAFQSTVNECCHLQENINSH
I-------QILS--------------------------Q-QLSKVESTSSG--LETELHY
ER-EALKEKTLA-VEH--IQGVL--SRTQCRLKD-----IEHMYQN-DQPIF------EK
YVRKQQSVEDGLFHLQSQNLLYQQQCNDAHKKV---DNHEETIINIRA----KCEDTVEK
LQAEC-RK----LEENNKELMKEC-TLLKERQCQCEKEKEEGEV--VMRQLQREVGDA--
--LNKQ------SLSEAMLEISSQRHINLEDETRDSKKKLGQLRSQ-VCMKLSMSTVS--
------------------------------------------------------------
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-----------------------------

------------------MKKIF---SKKG------------------------------
--------------------------------------------------------ESPL
GSFA----------------RRRRSSAGGGG----------------EPGEGAYSQPGYH
VRDRDLGK-----IHK---------------AASAGNV----------------------
AK---VQQILLLRK-NG--LN-DRDKM------------------NRTAL----------
----------HLAC--ANGHPEVVTLLVDRKCQLNV--CDNENRTALMK-----------
-AVQCQEEKCATILL-EHGADPNLADVH----GN--TALHYAV-YNEDISVATKLLLYDA
NIEAKNKD-D---LTPLL------LAVSGKKQQMVE-FLIKKKAN--------VNAV---
-DKLES-------SH-QLISEY--KEER--IPKNSSQNSNSVDESSED------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------SLSRLSG--KPGV--------------D----D--SWPTSDD---------
--------EDLNFDTKN-------------------VPKPSLAKLMTASQQSRK---NLE
ATYGIVRT------------------GNRTLFEDGDSDSQ--------------------
---------------------D-------------------EIVV---------------
------------------------------------------------------------
-----------------------------ESLPT--------------------------
----------------------------------TSVKVRDFSHPT--NQSPDLLP-KLS
HKS---------------------------------------------------------
----------------------------------------LANP----------------
-----------------------------------GLIKEEPTKPGIGKKE---------
---NGIDIVE----SAPLE--------------QTDNDN-------------LTYVDEVH
KNN----RS---------------------------------------------------
--------------------------D----------------------------VFYIP
SCMSGSRNFKMAKLEDTRNV--------------GMPVAHMESPERYLHLKPT----IEM
-KDSVPNK-----------------------------AGGKK------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------DV------------------
---------------------------------------------QTSK-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------AG
EHDLEVASEEQQET-EG-------------SENNQPQVE--------EERKKHR------
---------------------------NNEMEVS---ANIHDGATDDAED----------
DDDDDDDDGLIQ---------KRKSGETD----HQQFPRKENKEY---------------
---------ASSGPALQMKK-VKRTEK--EKQTSKESVNSPVFEKACLL-----------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------TGGLLQVDDDSSLSE-
-------------------IDEDEG---RPTKKTSNEKNK---VKNQIQSMD--------
------------------------------------------------------DV-DDL
TQSSETASEDCELP--HSSYKNFMLLIEQLG---ME--CKD--SVSLLKIQDA----ALS
CERLLEL---KKNH-------------------CEVLTVKIKKMEDK-------------
--VNVLQ----RELSETK---EIKSQLEHQKVE-WEREL--CFLRFSLNQEEEKRRNADM
LY-EKIREQ----LRRKEEQ------------------YRKEVEVKQQLELSLQTLEMEL
RTVKSNLN-QVVQERNDAQRQLSREQNARMLQDGIL-----TNHLSK--QKEIEMAQ---
-KKMNSENSH-----SHEEEKD---LLHK------NSMLQEEIAMLRLEIDTIKNQNQEK
EKKCFEDLEIVKEKNEDLQKAIKQNEETLT--------QTISQYNGRLSVL-T------A
ENAMLNSK-----------------------------------LENEKQSK---------
--ERLEAEVESYRSRLATAIYDR--DQSETSKRDLE----LAFQRARDECSRLQDKMNFD
VSNLKDNNEILS--------------------------Q-QLFKTESKLNS--LEIELHH
TR-DALREKTLG-LER--VQKDL--SQTQCQMKE-----MEQKYQN-EQVKV------NK
YIGKQESVEERLSQLQSENMLLRQQLDDAHNKA---DNKEKTVINIQD----QFHAIVQK
LQAES-EKQSLLLEERNKELISEC-NHLKERQYQYENEKAEREV--VVRQLQQELADT--
--LKKQ------SMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQ-LQEAQDRHTEAVR
C-----------------------------------AEKMQDHKQKLEKDNAKLKVTIKK
QMDKIEELQ----KNLLNA-----------------------------------------
------------------------------NLSEDEKE-QLKKL---MELKQSLECN-LD
QEMKKNVELEREITGFKNL-----LKMTR--------------KKLNE------YENG--
--EF-SFHGDLKTSQFEMDIQINKLKHKIDDLTAELETAGSKCLHLDTK-----------
-NQVL--QQELLSMKTIQKKCEKLQKNKKKLEQEVINLRSH---IER-NMVERGQVKQY-
KQEIEERARQEI-EEKLKEVNL---FLQAQAA-SQENLEQ-LREN-NFASMKSQMELRIK
DLESEL-SKIKTSQE------DFNKTELEKYK----QLYLEELKVRKSLS-SKLNKTNER
LAEVTKLL----------------------------------------VKINRKLIPREN
LVI-STSNPRASNNS-MENYLSKMQQELEKNITRELEEA-AAE-----LES-----G---
--------------------S-IASPLGST---------DES----NLNQDLVWKASREY
VQVLKKN--YMI------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
--------------WHPTTMTDSDKTCERSKNLKVDDKCLPVSPSTSKKQSDIKELGQTN
SIEQEKM----------NIG-VVL---------------LSANNTLH--DVC-QSQLPE-
----------------------NKKSK---------------E------EEQDLELPSEE
E---EERLKGRENKQPQ----KMSQEPEMAKDCDRED------------------IPVYS
LLPHVQNSEQMWIEQGKLEWKNKFKL-----------ITNELKQRFGE------------
------TGEKYKIP----------------------------------------------
----TCPEEEHLLDNSTRGTNVKDIPSNWTN-N-------------------------IP
GCEEEDASEVPVSVVFKTFPEQKEPSLKNVFP-----------SHPYSGSLEHACQSSCK
LHLHKNKSDSDSDNKPGIEHICSTDEN-FCNDAPTKKAR-NPEVVTVEMKE-----D---
QES-DLQMTKNKNRNSDSC-----------------------------------------
---------------------------STNNYKNLKPEL-E--NL-SFLLLDCDST---S
VHEELQ---QDMQRFKNEVDMIEEDL-----LALKKENIPLQKEVEEEIKQH---TSNNT
ELSG-----------SLPDGAAGG------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------SGDDGL-HQQ-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------FPRKE-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------N----------------E---VKNQIH-----------
---------------------------------------------------SRADF-ADS
MRPSETAS-ECEFS--HSTYENFLLLIEQLK---TE--CKD--SVSLSRIKDA----FHL
YEHFLEL---KNNN-------------------CERLTAEIKHMGNT-------------
--VSVLQ----KELSETK---DTKLQLEHQKIE-WEQEL--GSLRLALRQEKEKRENGDM
LC-NKHSEQ----LRIKEEE------------------CREKAEMTQRLKWTLRKLIKEL
RMVRKSLD-LVEQQRNDAQQQLSKEQNARVLQDQIL-----TS---K--QQELE------
--MAQKKMDSE-ISHRHKKEKD---LLHE------NCMLQKEIALLRLEIDTITNQNQQK
EKKYFEDIEAVKENNDNLQKIIKLY-ETLT--------KTIFQYSGQPNDL-AA------
ENKILNSE-----------------------------------LENEKQNQ---------
--ERPAIEMESYRCRLAAALC--DCDQSQT-QRDLN----HDFLRKRQEWIDLQDKTKAD
MSDLRATNEILS--------------------------E-KLTNVENKINS--LQIQLRN
TT-DAVEEKNLI-LEG--VQRDL--SQTQCQKKE-----IEQMYQT-EQNKL------KK
YIAKQESVEERLFQLQNENTLLRQQLDAAHKKV---NRQEKTISTLHD----QFQALARN
LQADS-EKQSLPLQE-NKELLDEC-HYFKNSMDQCEKEKPG RKD----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------DLTETQETAPSQCLHVDTE-----------
-NEVL--RQILFAMKAMKKKGQMLQKKNKELKQEVLNLKSY---IER-HMLKHYE-----
-VLIEGRSRQSK-VEKLKEISL---LLQ--VAASQEQFLQ--REN-DFASE RTQMELTIK
DLKSEL-SRIQTSQADK-------ETELERYK----ELFLEEVKAVKFWS-NELRRTNES
IEEVSTQLTVEKEKNR---YPAT------ASPTRPVLGLPFVGNLNDSEGLNRRHTQRKR
RSS---------DKR-LENLLWKMQQKLENDIPLGVGAA-TGSE-HGYPTV-----S---
--------------------PL------------------GFAHKANVNVDPVSEAVRDY
AQVLYRK--YKIW-----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

MVA-----EVYSMPAASSVKKPFGLRSKMGKWC---------------------------
----------YHCFPCCRGSGKSNVGTSGDHYDSAMKTLRSKMGKWCRHCFPCCRGSGKS
NVGTSGDHDDSFMKTLRSEMGKW-CCHCFPCCRGSGKSNVGAWGDYDD---SAFMEPRYH
VRGEDLDK-----LHR---------------AAWWGKV----------------------
PR---KDLIVMLRD-TD--VN-KKDKQKRV---------TRPGPGRRTAL----------
----------HLAS--ANGNSEVVKLLLDRRCQLNV--LDNKKRTALTK-----------
-AVQCQEDECALMLL-EHGTDPNIPDEY----GN--TTLHYAI-DNEDKLMAKALLLYGA
DIESKNKH-G---LTPLL------LGVHEQKQQVVK-FLIKKKAN--------LNAL---
-DRYGR-------TA-LILAVC--CGS-A-SIVSL-------------------------
--LL-EQN-IDV--------SSQD------RSG-QTARE---YA-VS---SHH---TV--
--ICQLLSDYKEKQMLKISSEN--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------SNPEQ-----------
---------DLKLTSEE------------------ESQ------------RFK-------
--------------------------------GSENS-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------QPE--------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------KMSQEPEINK-----------
---DGDREVK--------------------------------------------------
---------EEMKKHE--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----SNN------------------------------VGLL------------------
------------------------------------------------------------
-----------------------------------------E-------NL---------
--------------------------------------------------TNG-------
------------------------------------VAA---------------------
---G---------NG---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------D-DGLI---------------------------P----
----Q-------------------------------------------------RKSRTP
----------------------------------------ENQ-----------------
--QFPDNE------------------------------------------------S---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------EE--Y-HS---------------
------------------------------------------------------------
------------DEQNDTQKQFCEEQNTGILQDEIL-----IH---E--EKQIEVVE---
-K-MNSELSLS-----CKKEKD---LLHE------NSTLQEEIALLRLELDTMKHQSQLR
EKKYLEGIESASELAKTPMAAKKTKTKQKT--------KT-------NKQ-----KKRKK
KSSWKFFK-----------------------------------TFALF------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------MKRIFGFGSKKG------------------------------
--------------------------------------------------------EPPP
ASGS----------------PRRDG------------------------GPGPGVESGYL
LRDRDLGK-----IHR---------------AASSGNV----------------------
AK---VQQILLLGK-NG--LN-DRDKM------------------NRTAL----------
----------HLAC--ANGHTEVVTLLVERKCQINL--CDSENRTALIK-----------
-AVQCQDEECATILL-EHGADPNLADVS----GN--TALHYAV-YGQNIPIAAKLLSHNA
NIEARNKD-D---FTPLL------LAVSENKQQMVE-FLVKKEAN--------IHAV---
-DKIHS-------SR-QLISSY--KEEK--LPKNSSQNNNPEVEEISEE-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------DSLSRLSN--KPGI--------------D----D--SWPTSDD---------
--------EDLDFDNKN-------------------LPKPSLTKLMTASQQARK---NIE
EKDSIVRP------------------ENRTLLEDSSSESE--------------------
---------------------N-------------------EDVV---------------
------------------------------------------------------------
-----------------------------ETLPK--------------------------
----------------------------------LPVKGQGFSHAA--SPSPDPHI-KPF
LKS---------------------------------------------------------
----------------------------------------SAIP----------------
-----------------------------------GVTKEGTTKSAIEKKE---------
---NGIGIIE----SAPRE--------------QTNNDN-------------LTYDVGIH
KNN----RSDMMSALGLGEEEDIESPWDSESI-SESLPQKYVT---------------HL
SGATDQKGKNILNG---Q------IED----------------------------VFYIP
SCMSGSRNFKMAKLEDTRNV--------------GIPLAHMGSPEKYPHLKPV----VEM
-KDPEPNK-----------------------------AVGIK------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------NI------------------
---------------------------------------------QTSK-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------SA
ELDLKMISEEEQERLDG-------------SENNQPQVE--------EERKKHK------
---------------------------RNEMEVS---ENLYAAAAAEE------------
-----NDDGLTQ---------QRKNRKID----SQQYPVKGNA-S---------------
---------NCSSPALHMKE-VKKSEN--EKWTSKESVIAPMFEKTDSL-----------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------TGVLLQANDDSSLSE-
-------------------IDQDEG---RPAKKVSDEKNK---VKKQINSMD--------
------------------------------------------------------DF-DDL
TQSSETASEDFELP--NSNYKNSMLLIEQLG---MV--CKD--SVSLLKIQDA----VLS
YERLIEL---KKNH-------------------CELLTGKVKKMENK-------------
--VSELL----NELSETK---EMKSQLEHQRVE-WEQEL--CSLRFTLKQEEEKRRNADM
LY-EKIREQ----LRRKEEQ------------------YSKEVEMKQQLELTLRTLDMEL
RTVRNNLN-QVVEERNDTQRQLSREQNARLLQDGIL-----TNHLCK--QKEIEMAE---
-KKVSQNS--V-VSDSHEKGKD---LLHK------NHMLQDEIAMLKLEIDTIKNHNLEK
EKKYSEDFEIVKEKNVDLQRTLKLNEETLT--------KTVFQYSGQVNVL-T------S
ENAVLNSK-----------------------------------LESEKQNK---------
--ERLETEVESYRSRLAAAINDH--DQCQTSKRDLD----LAFQRARDEWFRIQDKMNFD
VSNLKDNNEILS--------------------------Q-QLSKTESKFNN--LEIELHH
TR-DALREKILT-LER--VQRDL--SHTQCQMKE-----IEHMYQN-EQGKV------NK
YIGKQESLEERLSQLQSENMLLRQQLDDAHNKA---DNKEKTVINIQD----QFQDIIKN
LKAES-EKQSLLLEERNKELINEC-NHLKDRLYQYENEKAEREV--VVRQLQQELADT--
--LKKQ------SMSEASLEVTSRYRINLEDETQDLKKKLGQIRCQ-LQEAQDRHTEAVR
C-----------------------------------AERTQDHMQKLEIENTKLKVTVKK
QLGKIEQLQ----KNLSGS-----------------------------------------
------------------------------NSSEEEKE-QLKKL---TELKQSLEYS-LD
QEMKKNSELEKEIIGFKKL-----LKMTR--------------KKLNE------YENG--
--EL-SFHGDLKTNQIEMDIHINMLKHKIDDLTAKLETTSSKCLHLDAN-----------
-NQVL--QQELLSMKAIKKKCEKLEKNKKKLEQEVVNLKSH---VEI-NMIEHGQVEQY-
KREIEERARWDI-VEKLKEVNL---FLQTQAA-SQENLEQ-IREN-NNASIRSQMELRIK
DLESQL-CKMKTSQE------DSNKAELEKYK----QLYLEELKVRKSLS-NKLNKTNER
LAEISTKLIVEKQQ---NRSLVN------TLTVRPVLEPPCVGNLNNSLVLNRNIFPREN
LVI-PPSSPRSSNNS-METYLTKMQQELEKNITRELEEA-AAE-----FES-----G---
--------------------SCRASPLGST---------DES----NLNQDLVLKTSQEY
VQILKKN--YMI------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

-----------------MFKKFFSLKQKNT------------------------------
--------------------------------------------------------QPQA
CSST--------------TPRRDSG------------------------VDGTAISEGYH
LNKKDLGK-----LHR---------------AASTGDV----------------------
AK---VQWLLLLKK-QE--IN-ETDKL------------------NRTPL----------
----------HLAC--ASGYPDVVSLLVERNCSLNV--CDGDSRTPLIK-----------
-AVQCQQEECVGILL-SHGADPNVVDTR----SN--TALHYSS-LCHNTAIAAKLVEHKA
DIEAKNQE-G---YTPLL------LAITEHNEEMVD-FFLKNGAN--------VNAC---
-DNSKR-------TA-LMIAVS--TEPT--SIVNL-------------------------
--IL-QYN-IDL--------SFQD------NDG-WTAED---YA-LV---SGI---PV--
--HRELVLQ---YGKRQLNQLPS-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------A--------------
----------NI--SR--P-------------------------DGASDIGF--------
-----------T------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--LGKPAL-------------------------------------------DK-------
------------------------------------------------------------
-------------------------------------------------EG--QDIQKSH
CTGPK-------------------------------------------------------
-------------RNQSRK-------------------------------------D---
------------------------------------------------------------
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-----------------------------

------------------------------------------------------------
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--------------------------------------------------------PKYH
LKDKDLRK-----IHK---------------AARDGDA----------------------
AR---VQQLLLGKH--C--VN-DKDKK------------------KRTAL----------
----------HIAC--AYGHPKVVMALVEGKCEVNA--TDSEECTSLVK-----------
-AVQCQEEECATILL-ENNADPNIVDAQ----GN--SALHYAV-YYKNTSLAAKLLDHEV
NIEATNKD-G---FTPFL------LAVSENKLKIAK-FLLMKNAS--------IHAA---
-DNQKR-------TA-LMHAVS--HDST--NLVRF-------------------------
--VL-EQG-VDL--------FVKD------AFG-LTAID---YA----------------
------------------------------------------------------------
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-----------------------------

------------------------------------------------------------
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--------MMEKKKTMD--LN-MRDGR------------------NRTAL----------
----------HLAC--AFGHEKVVTLLVDRKCQIDV--CDKEHRTPLMK-----------
-AIQYRKEGCANILI-DSGADITIADVN----GN--TALHCAI-YIESLSMVAKLLSHGA
DIEVKNKA-T---LTPLL------LAITKRNVQIVE-FLLSKKAN--------ANAV---
-NEYKC-------TA-LILAVY--HRSS--EIVGM-------------------------
--LL-QQN-VDI--------YAED------MRG-LTAER---YA-AA---YGF---DE--
--ILEQLLDYKQKTSK-Y-PQNS-----NPGKTSD---------------IKLL----FG
TLDMVAGLAEGTLDEAARLAEATPD-EDAHLVERTSEE----------------------
-----------------------------------------------------VKCLV--
--------------------------------------------ERT------PEKAAP-
--------LVEGS-SD--K--I---RYLRNAT-SGRIEQSAE--ETPM-----------K
PAKETSA--KFAWTAQ--------------------------------------------
----------------------GKP-TQIT----------WVEEK------------Q--
------------------------------------------------------------
------------------------------------------------------------
-------------------------------PEK--------------------------
---------------------------T--------------KCLA--SVTSYKTEVVET
G-------------ISEMSERS--------------------------------------
------------------------------------------------------------
-----------------------------------TEETSTKASTN--------------
------------------------------------------------------------
---------DQMFPSESEEEEDETKSWDSEVL----------------------------
--------------CI-----------------------T--------------------
------------------------------------------------------------
-----------------------------------------------DFFKNQM---F--
PSE-SEEGEDETKSWDSESLFESVQEN---------------------------------
------------------------------------HVCLHDATYQQ--KI---------
---KT---IFGKLVGKNHFLF--KKSFYRIF----------E------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------DEKNSWD------------------------------------
----------------------------------SEVL----------------------
--CISDKSTAN----------------------------IILNGQKLEAF-----P----
-----------------------------------------------------MKTG---
-T------------------------------------------------RQG---CPLS
PFLFSIV-------------------L--EVVARAIRQEKEIKGIQ----LGKEEIRLS-
---------------------EDEKN------SWD------------S---E---SLSES
VQ---------------------------------------------------------Q
KYVCLPDAAYQ-------------------------------------------------
----------KEIKTINGKM----------------------------------------
------------------------------------------------------------
-------EGKS----------------PFPFCGMKDSVPNKALEL-KDI-----------
-QRFKNKKS-DFIIFNVSIFVEKNIPNSKYTFV---------------------------
-------------------------------------------------NSE--------
------HAAQNYMCLPQTSYQKEIKTINGKIEEHVLFGFLFL------------------
---------------CH---------F-------AE----N-------DGHELILF----
--------------------------------FMTPPKKPSDFEPAIEM-----------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------QN-SVS-NIALEWKNEQTLGA-
-----------------------------INIYFSVY---------ELV-----------
----------------------------------------------------------NV
KICRSLYPKSTNIFYFCLLL------------------ETD--SPILSKILDV----EPS
CKRAREL---KIYH-------------------CKQLTEKMKQMKKK-------------
--VCELQ----KELSEAK----IKFQLENEKVK-WQQEL--CSVRFTLNQEEEKRRNIDM
LN-ENIREE----LGRIKEQ------------------HRKELEVRQQIEMAHRMQDMEL
KSLRSNF-----------------------------------------------------
---------NQ-VSHTRENEND---LLHE------DCVLEKEIAMLKLERDTLRHLNQEK
ENKYFEDMKILKEKNAELQITLKQKKKTLT--------KRAPEYSEQLKVL-T------A
ENTMLTSK-----------------------------------LK-EKQDK---------
--EILKTEIESYHPRLASAIQDH--DQNVASSKKQE----LAFHASGDAHL--QGKMNVD
VNNVIYNNEMPH--------------------------Q-PLSEVQSKSKS--LKM-TNY
AG-DAVRENTLV-LEH--AQRDL--SEIQCQLKK-----VEYMYKN-EEDNV------HP
HTEQQESLEQRLLQLESKNIWLRQQLVHALKKA---NNKSKITINIRF----LE------
----R-KKEHHLLREKNEEIVNNC-KRLKECIYQYEKEKAERE-----------------
------------------------------------------------------------
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-----------------------------

------------------------------------------------------------
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------------------------------------------------------------
-----------------------------------------------TAL----------
----------HWAC--ANGHAEVVTLLVDRKCQLDV--LDGENRTPLMK-----------
-ALQCQREACANILI-DSGADPNIVDVY----GN--TAVHYAV-YSDNLSVVAKLLSCGA
DIEVK-KA-G---HTPLL------LAIMKRSEQIVE-FLLTKNAN--------ANAV---
-DKFKC-------TA-LMLAIC--HGSS--EIVGMVLQQN--------------------
---------VDI--------CAED------TCG-MTAER---YA----------------
--------------------VAC-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------G--------------
----------FN--L---------------------------------------------
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-----------------------------

------------------MKKLFSFWRR--------------------------------
--------------------------------------------------------KDES
-------------------RSSSSHV-----QI----------GLART--------GCYN
LRERDLKK-----LHK---------------AASVGDL----------------------
EK---VQECLQLKK-HD--VN-MLDKE------------------YRTPF----------
----------HLVY--ANRYTNIVSLLIEKQCKINV--QDRENRSPLI------------
---KCQKENCTTLLL-NLGADPNLVDFE----SS--SALHYAV-CGHSVSLVEKLLEHKA
SLEAQNKA-G---YTSF--------AVSEDNAEMVE-FLLKKGAD--------VNAS---
-DNSQR-------TP-LMIALS--NEPT--SLVSF-------------------------
--IL-QQD-VDL--------SCQD------IYG-FTAEE---YA-SF---NGF---TV--
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-----------------------------

MGGKCSRGGERRPLGFPGFSALCCCQIKSR------------------------------
---------------------------------------------------------EET
PLGF--------------CDIKARRNNS---------------------CFGREDPAYLD
MAYFPDND-----LHM---------------AACAGDL----------------------
PF---MRLYFTLG-KYE--VN-HRDRE------------------NRNAM----------
----------HFAC--FYGHLELVIYLWRRGCEINV--CDNHNITPLMK-----------
-AVQSWEDEIVCFLL-EHHANLHIKDSR----GN--TALHYAV-YGGNSAMAARLLEYGA
DIEERTKD-N---LTPLL------LALKENRLKMAQ-FLVRMEAS--------VHAV---
-DSQRR-------NS-LMYAVR--CDCP--VMVNL-------------------------
--IL-QQG-ADI--------NLKD------LFG-WTALR---YA-IE---GDR---D---
--V---------------------------------------------------------
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-----------------------------

----------------------MGVRE---------------------------------
---------------------------------------------------------SFL
G-----------------ACRRR--------MA----------TWRENRGKHGFSNPGYR
VRQKDLGM-----IHK---------------AAIAGDL----------------------
NK---VMESILLRL-ND--VN-DRDKK------------------NRTAL----------
----------HLAC--AHRRPGVVADLVARKCQLNL--TDSENRTALIK-----------
-AVQCQEEVCASILL-EHGADPNVRDMY----GN--TALHYAI-DNENISMAGKLLAYGA
DIEARSQG-E---HTSLL------LAVNRKKEQMVA-FLLKKKPD--------LTAT---
-DNFGS-------AQ-ILPA-K--NGEE--RQIRTLHHSVW-------------------
F-PL-PR--------GNSVVYLD-------------------------------------
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-----------------------------

------------------------------------------------------------
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------------------------------------------------------------
-----------------------------------------------TAL----------
----------HLAS--ANGNSEVVKLLLDRRCQLNI--LDNKKRTALTK-----------
-TVQCQEDECALMLL-KHGTDPNIPDEY----GT--TTLHYAI-YNEDKLMAKALLLYGA
DIESKNKH-G---LTPLL------LGVHEQKQQVVK-FLIKKNAN--------LNAL---
-DRYGR-------TA-LILAVC--GGS-A-SIVSL-------------------------
--LL-EQN-IDV--------SSQD------LSG-QAARD---YA-VS---SHH---NV--
--ICQLLSDYKEKQMLKVFSEN--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------SNPEQ-----------
---------DLKLTSEE------------------ESQ------------RLK-------
--------------------------------GSENS-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------QPE--------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------KMSQEPEINK-----------
---DGDREVE--------------------------------------------------
---------EEMKKHR--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----SNP------------------------------VGFP------------------
------------------------------------------------------------
-----------------------------------------E-------NL---------
--------------------------------------------------TNG-------
------------------------------------ATA---------------------
---G---------NG---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------D-DGLI---------------------------P----
----Q-------------------------------------------------RKSRTP
----------------------------------------ENQ-----------------
--QFPDTE------------------------------------------------SE--
------------------E-----------------------------------------
----------------------------------------------------YH------
-RDFSGHPSLP-------------------------------------------------
------------------------------------------------------------
-----------------------------T------------------------------
-------TLPIKH-----------------------------------------------
------------------------------------------------------------
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-----------------------------

MQEDIDN-------DGQTPSPSA------S------------------------------
---------------------------------------------------------ERA
HWYA--------------CM--WNACLGYGC--------------LE--VQ-TEDCPEYL
ITYVPVGH-----FQR---------------AASMGDV----------------------
ST---VQHFITSR-GYH--VD-NPDRR------------------RRTSL----------
----------HYAC--VYNHPDVVLLLIENNCNINA--QDDDGCTPLIK-----------
-ATEHNNLECVSILL-KGGADPHIKDSN----GN--TALHYAV-YTGNKAIVSELLEHKV
DINIETQH-G---LTPFS------LAVSENKKQMAE-FL---------------------
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-----------------------------

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---------------------ACASD--H------V----KVVTL-LVSR----------
--KCQI------------------------------------------------------
-----------------------------------------------------DICDKEN
R-----------------------------------------------------------
-----------------T--------PLIQAFHCQ-------------------------
----------EEACTVILLE-HGTNPNL-----------KDIY-----------------
------------------------------------------------------------
--------RNTALHYAVYSE--STS--LAEK-------------LLFHGANIEALDKKEK
MVEFLKTKA-----STHAVDRLRWSALMIAIHYDSPGIVNILLKQNIDVFTKDINF----
--IYYFC--ICRIQQQILEHKKKILK-KEKRGKASES-EF---LTSLGGPTLDKKIRILS
VATKQCVPEKVSEPLCRPSHEKGNRIVNGKGEGENH-------ILFKKPPA---------
KHPSLKPSTDVEDP--ANV----QT-L-------------RAEQTLPV-------ALQEE
QERCERS---EKKQ------------------------PQVKEGNNTNKSEKIQLSENVC
HSTSSAA---ADRLTKERKIGKMYPQQF-------PKKLKEEHDRCILRQENEEKTNVNM
LY-KKNREE----LERKEKQ------------------HKK---------------EMKP
KTARNTPN----------------------------------------------------
----------Q-DFHNHEEMKD---LMDE------NCILKTDISILRQEICSMKNDNLEK
ENKYLKDVKIVKKTNAALEKYIKLNEELIT--------KTAFWYQQELNDV-KA------
ENTRLISE-----------------------------------LLKEEESN---------
--KRPEAETESYQSRLAATISKH--SESVKTERNLK----LALERTQDV--SVQVKMSSD
ISEVEDKNEFLT--------------------------E-QLSKTQNKFST--LKDKFRK
TR-DTLRKKSLA-SET--VQNDL--SQTQQQIKE-----MKEMYQN-AEAKV------SN
STGKWSCVEERICQLQHENLCIEQQLDDVHQKE----YHKEIVTNIQR----GF------
--IEK---------EKNKKLMNEC-DHLKESLFQYEREKAERVV--SIKEDKY-FQTS--
--RKKI------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-----------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------XTSL----------
----------HYAC--AHNHPDVVTLLLENNSSINI--RDDEGCTPLIK-----------
-ATQRDNVDCASVLL-THNADPNLIDSS----GN--TAFHHAI-SRGNIRIVKMLLEHNV
DIEAKTEY-G---LTPLQ------LATFEQKPEMVE-FLAAKCAK--------SSVT---
-PSWSP-------SP-TVSPCP--SSTS--PLSSL-------------------------
--GL-PVC-PNP--------GTSS------LSE-DRKSS---SA------RRI-------
-KL---------------------------------------------------------
STGSSAQRTEVKHVRFN-EEVLYF------KEERPLSCEARPPGQLKSILKNT------V
--------------------------------------QYNTVNEKITRRTSLW------
------CSKAEDVR------------------YTSCIKVKCFSVKSSLL-----------
------------------------------------------------------------
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-----------------------------

MGGKYSLERWRWPGCSGGFSVLCGKQKKSL------------------------------
---------------------------------------------------------VET
PLGF--------------CDIEAQGNNL---------------------SFGTQNPSYLD
MAYFPDND-----LHM---------------AACAGDL----------------------
PF---VRLYFTLG-KYD--VN-HRDKD------------------NRNAL----------
----------HFAC--FYGHLDMVNYLWRRGCQINV--CDKHNITPLMK-----------
-AVQSWEEEIVCYLL-ERHANLHIRDSS----GN--TAFHYAV-YGGKPAMAARLLQYGA
NIEERTKD-N---LTPLL------LALRENRLHMAQ-FLIKMEAS--------VHAV---
-DSHRR-------NS-LMYAVR--CDSS--VMVNL-------------------------
--LL-QQG-VDM--------NFKD------LFG-WTALR---YA-IE---VI--------
------L-------------------------------------------------INI-
NSDAGTTSSTATENMIEMQDPLTT------NEAGVK------------------K-TET-
---------CQPAS------------------------ASST---VLERD----------
----------GN-----------------------------SGQCYLIP-----------
--------ISLGLLSF--FFSI--------------------------------------
------------------------------------------------------------
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-----------------------------

------------------MNKLFSFWKRKN------------------------------
--------------------------------------------------------ETR-
-------------------------------------------------------SQGYN
LREKDLKK-----LHR---------------AASVGDL----------------------
KK---LKEYLQLKK-YD--VN-MQDKK------------------YRTPL----------
----------HVAC--ANGHRDVVLFLIEQQCKINI--RDSENKSPLIK-----------
-AVQCQNEDCATILL-NCGADPNLRDVR----YN--TALHYAV-CGQSFSLVEQLLDYEA
DLEAKNKD-G---YTPLL------VAVINNNPKMVK-FLLEKGAD--------VNAS---
-DNYQR-------TA-LILAVS--GEPT--RLVKL-------------------------
--LL-QQG-I--------------------FVDSQLRNM---LI-SM---VLL---YI--
--HNSLQVMERRNMLN--RHLIL-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------G--------------
----------TA--CD--------------------------------------------
------------------------------------------------------------
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-----------------------------

MVA-----EAGSMPAASSVKKPFGLRSKMGKWCRHCFAWCRGSGKSNVGTSGDHDDSAMK
TLRSKMGKWCCHCFPWCRGSGKSNVGTSGDHDDSAMKTLRSKMGKWCCHCFPCCRGSGKS
NVGTSGDHDDSAMKTLRSKMGKW-CCHCFPCCRGSGKNKVGPWGDYDD---SAFMEPRYH
VRREDLDK-----LHR---------------AAWWGKV----------------------
PR---KDLIVMLKD-TD--MN-KKDKQK------------------RTAL----------
----------HLAS--ANGNSEVVKLLLDRRCQLNI--LDNKKRTALTK-----------
-AVQCQEDECALMLL-EHGTDPNIPDEY----GN--TALHYAI-YNEDKLMAKALLLYGA
DIESKNKH-G---LTPLL------LGVHEQKQQVVK-FLIKKKAN--------LNAL---
-DRYGR-------TA-LILAVC--CGS-A-SIVSL-------------------------
--LL-EQN-IDV--------SSQD------LSG-QTARE---YA-VS---SRH---NV--
--ICQLLSDYKEKQILKVSSEN--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------SNPEQ-----------
---------DLKLTSEE------------------ESQ------------RLK-------
--------------------------------GSENS-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------QPE--------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------EMSQEPEINK-----------
---GGDRKVE--------------------------------------------------
---------EEM------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
-----------------------------------K--KHG--STHMG------------
-------------F-------------------PENLTNGATADNGD-------------
--DGLIP----PRKSRTP---ESQ-----QFPD-TENEQ--Y-HS---------------
------------------------------------------------------------
------------DEQNDTQKQLSEEQNTGILQDEIL-----IH---E--EKQIEVAE---
-N-EF-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-----------------------------

MVA-----EVGSMPAASSVKKPFGFRRKMGKWG---------------------------
----------CHCLPCCRGSRKSNVGASGDQDDSAVKTFRSKMGKWCCHCLPCRRGSGKS
NLRPSGDQDDSAMKTLRS-----------------SKSDVGAWEEYDD---SAFMEPRYH
VCREDLDK-----LHR---------------AAWWGKV----------------------
PR---KDLIVMLRD-TD--VN-KTDKQK------------------RTAL----------
----------HLAS--ANGNSEIVKLLLDRQCQLNV--LDNKNRTALTK-----------
-AVQCQEDECALMLL-EHGTDPNIPDEY----GN--TSLHYAI-YNEDKLMAKALLLHGA
AIESKNKH-G---LTPLL------LGVHEQKQQVVK-FLIKKKAN--------LNAL---
-DGYGR-------TA-LILAVC--CGS-A-SLVSL-------------------------
--LL-EQN-IDV--------SSQD------LSG-QTARE---YA-VS---SHH---NV--
------------------------------------------------------------
------------------------------------------------------------
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-----------------------------

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------------MAYFPDNDLHMAACAGDLPFMRLYFTLGKYEVNHRDRENRNAMHF---
----AC--FYGHLELVIY LWRRGCEINVCDNHNIT PL--MKDN---LTPLLLALKENRLK
MAQFLVRMEA----SVHAVDSQRRNSLMYAVRCDCPVMVNLILQQGADINLKDLFGWTAL
RYAIEGDRDVRTI--LLE-Y--EYNLIQRLRERNQEFQSSEDSSIRPINEVDA---E---
V---------TSSMA------------------------------IEKV----IEL-QDP
LTTSETSV----------------KKIQ-T--------CRSESELEVISLED-----EIS
GKETINN---PQQQCCKF------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-----------------------------

------------------MKKIFGFRS-KG------------------------------
--------------------------------------------------------PSPL
GPSA----------------RPRSNCVGFGR----------------EGA-SGSLTPRYH
IHDKDMGK-----IHK---------------AASAGDV----------------------
AK---VQHILILGK-SG--VN-DRDKK------------------DRTAL----------
----------HLAC--AYGHPEVVTLLVERKCEIDA--RDGENSTALIK-----------
-AVQCQEEECATILL-EHGADPNVMDSS----GN--TALHYAV-CSENTSIAARLLAHNA
NMEAKNKD-D---LTPLL------LAVKEKKQHIVE-FLVKKKAS--------IHAV---
-DQLGS-------N--RQIFEY--DGRR---LK-SSENSNPVDNGSED------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------ESLTRSSN--TPDP--------------A----D--SWPTSDE---------
--------DEYNFDSKN-------------------VPKINLTELWAAAQQSKKN----Q
TKCGFENL------------------ENRILFDNSNSNSE--------------------
---------------------I-------------------EDAV---------------
------------------------------------------------------------
-----------------------------EIGPG--------------------------
----------------------------------TSARVQTS-SLS--CQSPDP------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------MEGATEPATGREENGADAVENV
SQENGADAVE----RASQE--------------QPNGDN-------------LTCAGGWH
RSN----KSEMMSALGLGEDEEEESPWDSESI-SDSVSLKGVG---------------HL
SGTADQTGETKVHG---Q------DED----------------------------VTYIP
SCMSGSRNFKMAKLEESRNV--------------GIPVAHKEALRKYPVMEPT----IKR
-MDPVLYK-----------------------------TVGMK------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------DVPT----------------
--------------------------------------------F---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------KS
EPDIEIVPREEQRRLSS-------------SEDSQRQV---------EEKRNYK------
---------------------------TSEAKVS---GSLCDGSVDSV------------
------GNGVNQ-----------QSGKTD----NQQLPLKRHEER-----------DR--
-------LFLSSGPALLMKE-VKKKES--EKRVPRESVLMPVTEEAGSP-----------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------PGGSSQMQDGSSLSD-
-------------------TDHSEM---RPIKKTSNKNNK---VRKQVAAVD--------
------------------------------------------------------DL-DDL
NESSETASEDCELQ--CPDYESVLCEIEHLR---ME--CRD--IVSLLKIRDA----VYS
YKRLIEF---KKSH-------------------CELLTGKLKRMENK-------------
--FKESQ----KEISETK---EVRSQLEHEKVE-WEQEL--SNLRFALKQEEEKRRSADQ
LS-EKTMDQ----LRRKDEQ------------------YQNEVDEKQQLEVSLRTLDMEL
KTVRNHLN-QVLEERNEIQRQLSREQNARMLQDGIL-----ANHLSK--QKEIEMAQ---
-KKMTSEVSV-----SQEKEKD---LLHK------NQRLQDEIAMLRLEMDTVKTHSQEK
EKKYLEDIKTANEKSDKLQRMIKLNEETFT--------KTIFQYNGQINNL-T------T
ENTMLSSK-----------------------------------LENEKQNK---------
--ERLETDIESFRSRLASAMHDH--AEIQTSKRDLE----IAFQRARDEWVRLQDKMNFD
MSNLRDNNEILS--------------------------Q-QLSKTEKKLNS--LEIEFHH
TK-DALREKTLA-LKH--VQRDL--NQTQCQMKE-----VEHMYQD-EQGKV------NK
YMGKQESIEERLSQLQSENMLLRQQLDDASNKA---DSKDKTIVDIQD----QFHDMLSR
LQAES-QKHRLLLEDRNKELVSEC-SHLKERMCQYENEKAER EV--IVRQLQQELADT--
--LKKQ------SMSEASLEVSSRYRSNLEDEARDLKKKLGQIRNQ-LQEAQDQHREAVQ
R-----------------------------------AEKTQDHLQKLELENSNFKITIQK
QTEEIEQLQ----ENLSSV-----------------------------------------
------------------------------NLSEEDKE-KLKKL---AELKESLEYT-LD
QEQKKNDALEKELTEFKEL-----LQMTK--------------KELNE------HENR--
--EL-NHNQDSKNSQFEMDISVNMLINKIDDLTTKLETASSKCLHLGKK-----------
-NQVL--QQELLLMKSIQKKCVKLEKHKKRLEEEVDRLRSH---MEK-HMVEHSQVQQY-
QREVEERARQDL-VEKLKQVNL---FLQAQAA-SQENLEQ-LREN-SNASV RTQMELRIK
DLESQL-SRMKT-QE------DFDKIELEKYK----QLYQEEFQVRKLLS-SKLSKTNER
LEEASTKLHLEEQQ---NRSLLS------SLSTRPVVECPCVGSLHNSLVFNRALIPREN
IVI-PTSSLQPSNKR-MEIYLTKMHQELEKSINRELKEA-AAE-----LES-----E---
--------------------FCRVSPLGSA---------TKP------SQDLLSEASQEY
IDILKKK--YTIC-----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

-------------------MKLFGFGSRRG------------------------------
--------------------------------------------------------QTAQ
GS----------------------------------------------ID-HVYTGSGYR
IRDSELQK-----IHR---------------AAVKGDA----------------------
AE---VERCLARRS-GD--LD-ALDKQ------------------HRTAL----------
----------HLAC--TSGHVQVVTLLVNRKCQIDV--CDKENRTPLIQ-----------
-AVHCQEEACAVILL-EHGANPNLKDIY----GN--TALHYAV-YSESTSLAEKLLSHGA
HIEALDKD-N---NTPLL------FAIICKKEKMVE-FLLKKKAS--------SHAV---
-DRLRR-------SA-LMLAVY--YDSP--GIVNI-------------------------
--LL-KQN-IDV--------FAQD------MCG-RDAED---YA-IS---HHL---TK--
--IQQQILEHKKKILKKEKSDVG-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------S--------------
----------SD--ES--A-------------------------VSIFHEL---------
------------------------------------------------------------
--------------------------------------------R---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------V----------------------------------------------------
------------DSLPASD-----------------------------------------
------------------------------------------------------------
----------------------------------------------------------DK
-DLNVATK--------------------------------------------Q-------
------------------------------------------------------------
-------------------------------------------------CV--PEKVSEP
LPGSS-------------------------------------------------------
-------------HEKGNR-------------------------------------IVNG
QGE---------------------------------------------------------
------------------------------------------------------------
-------------------GPPAKHPSLKPS-T---------------------------
---------------------------------------------------EVEDPAVKG
------------------------------------------------------------
----------------------------AV-------QRKNVQTL---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------RAEQALPVASEEEQERHER--SEKKQPQVKEGNNTNKSEKIQL--SEN---
------------------------------------------------------------
------------ICDST-------------------------------------------
--------------------------------------------SS--------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------AAAGR-LTQQRKIGKTYPQQFPKK-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------L-----------------------------------------------------
-------------------------------------KE--EHDRCTLKQENEEKTNVNM
LY-KKNREE----LERKEKQ------------------YKKEVEAKQ-LEPTVQSLEMKS
KTARNTP-----------------------------------------------------
---------NW-DFHNHEEMK---GLMDE------NCILKADIAILRQEICTMKNDNLEK
ENKYLKDIKIVKETNAALEKYIKLNEEMIT--------ETAFRYQQELNDL-K------A
ENTRLNAE-----------------------------------LLKEKESK---------
--KRLEADIESYQSRLAAAISKH--SESVKTERNLK----LALERTRDVSV--QVEMSSA
ISKVKAENEFLT--------------------------E-QLSETQIKFNA--LKDKFRK
TR-DSLRKKSLA-LET--VQNDL--SQTQQQTQE-----MKEMYQN-AEAKV------NN
STGKWNCVEERICHLQRENAWLVQQ-LDDVHQK---EDHKEIVTNIQR----GFI-----
---ES-GKKDLVLEEKSKKLMNEC-DHLKESLFQYEREKTEGVV--SIKEDKYFQ-TS--
--RKTI------------------------------------------------------
------------------------------------------------------------
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-----------------------------

----------------MKKILVHG----VK------------------------------
---------------------------------------------------------EKT
PMGF--------------CDVPRKNLLDFLR--------------DM-----KSISVPNE
PRYKPLRK-----IHQ---------------AASEGDT----------------------
DR---LRRMISLG-KHS--VH-DRDFK------------------QRTAL----------
----------HFAC--AYGQVEVVSVLLRNNCDIDA--ADVNFITPLMK-----------
-AVQNWTYECVCILL-KHGADPNHMDKN----GN--TPLHYAV-SEDNQTLAKCLLKYSA
NMEQKNKD-G---FTPLL------LALKENKIEMAK-FLVKMGAN--------IHVF---
-DEMKR-------NT-LLYAIR--WDSK--DMVNL-------------------------
--LL-DEG-IDF--------FFRD------VFG-WTALR---YA-IE---GTS---K---
-GSREILMNYDEMLRRKNKDGIPEYKNFEDK---------------------LLDKHPN-
DPTSGSSFPKSNEKACEFDDEADI------SKYVLTTCPNNIHGAGEQGDKSETKGAADV
Q------VWTNPTL----------KSSTKGKV-----PNLNEVGTMTESHHFIK------
------ESDLKI-----------------------------ESLEETFSYDNEDKQ--SV
--------SDDGHFSG--TTPE-----------WCQN---DT--NRKTTAKD--CMYP--
-----------NLKSST------------------EGKMPTR-SKTGKMAEPP-------
-------------HFIIESDLEIESLEETVSCDSE-----DK------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------QLLV----------------------------------------------
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-----------------------------

MVT-----EVCSMPAASAVKKPFDLRSKMGKWF---------------------------
----------HHRFPCCKGSGKSNMGTSGDHDDSFMKMLRSKMGKCCHHCFPCCRGSGTS
NVGTSGDHDNSFMKTLRSKMGKW-CCHCFPCCRGSGKSNVGAWGDYDD---SAFMEPRYH
VRREDLDK-----LHR---------------AAWWGKV----------------------
PR---KDLIVMLRD-TD--MN-KRDKQK------------------RTAL----------
----------HLAS--ANGNSEVVQLLLDRRCQLNV--LDNKKRTALIK-----------
-AVQCQEDECVLMLL-EHGADQNIPDEY----GN--TTLHYAV-HNEDKLMAKALLLYGA
DIESKNKC-G---LTPLL------LGVHEQKQQVVK-FLIKKKAN--------LNAL---
-DRYGR-------TA-LILAVC--CGS-A-SIVNL-------------------------
--LL-EQN-VDV--------SSQD------LSG-QTARE---YA-VS---SHH---HV--
--ICELLSDYKEKQMLKISSEN--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------SNPEQ-----------
---------DLKLTSEE------------------ESQ------------RLK-------
--------------------------------VSENS-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------QPE--------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------KMSQEPEINK-----------
---DCDREVE--------------------------------------------------
---------EEIKKHG--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----SNP------------------------------VGLP------------------
------------------------------------------------------------
-----------------------------------------E-------NL---------
--------------------------------------------------TNG-------
------------------------------------ASA---------------------
---G---------NG---------------------------------------------
------------------------------------------------------------
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----------------------------------------------D-------------
--DGLIP----QRRSRKP---ENQ-----QFPD-TENEE--Y-HS---------------
------------------------------------------------------------
------------DEQNDTRKQLSEEQNTGISQDEIL-----TN---K--QKQIEVAE---
-KKMNSELSLS-----HKKEED---LLRE------NSMLQEEIAMLISGDWN--------
------------------------------------------------------------
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-----------------------------

------------------MRKLFSFGRRLG------------------------------
--------------------------------------------------------QALL
SS----------------------------------------------RD-KEYAGPVYH
IRDWELRK-----IHR---------------AAIKGDA----------------------
VE---VERCL-RRF-RD--VD-ARDRK------------------DRTVL----------
----------HLAC--AHGHVEVVTLLLSRICQIDI--CDRLNRTPLMK-----------
-AVQCQEEACAIILL-EHGANPNIKDIY----GN--TALHYAV-YNKGTSLAEKLLSHHA
NIEALNEE-G---NTPLL------LAINSTRQQMVE-FLLKNQAN--------IHAV---
-DNFRR-------YN-SHSSHS--VVSI--DSLPV-------------------------
--LL-PL-----------------------------------------------------
------------------------------------------------------------
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-----------------------------

------------------MERLSAAAVKG-----Q-------------------------
--------------------------------------------------------TGLE
CPSP--------------FSQL-----------------------------VYTNNDSYV
IHHGDLRK-----IHK---------------AVSQGQA----------------------
WK---LERMMK-TTTMD--LN-IRDAK------------------KRTAL----------
----------HWAC--ANGHAEVVTLLVDRKCQLDV--LDGENRTPLMK-----------
-ALQCQRESCANILI-DSDADPNIVDVY----GN--TAVHYAV-YSENLSVVAKLLI---
---------------------------RKRSEQIVE-FLLTKNAN--------ANAV---
-DKFKC-------I----------------------------------------------
------------------------------------------------------------
---DQQLLEYKQKISK-N-SQNS-----NPEGTS------------------------EG
TPDEAAPLAERTHLTWLKAWWKEHL-TN--------------------------------
------------------------------------------------------------
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-----------------------------

------------MGLAAW------------------------------------------
------------------------------------------------------------
--FLQ-------------ACKRRGTSWRKNP----------------HKDDYGFSNTLYR
IRQKDLGM-----IHK---------------AAIAGDV----------------------
NK---VDQILLLRE-NE--IN-DTDKK------------------MRTAL----------
----------HWAC--AHGHPGVVTHLVARKCQLNL--SDSKHRTALIK-----------
-AVQCQNDVCAYILL-EHGADPNIIDTY----GN--TALHYAI-DNENIPMAGKLLACGA
DIEARSQG-E---LTSLL------LAINRNKEQMVA-FLLKKKPD--------LTAV---
-DNFKR-------TAL-ILAAR--NGS-------------------TS----------VV
YQLL-QHN-IDV--------VFQD------ISG-WTAED---YA-VA---YNF---Q---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------DICR--------------LI
SEYK--------------------------------------------------------
------------------------------------------------------------
-----ANK-------------------------------KC-------------------
------------------------------------------------------------
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------------------------------------------------------------
---------------------------------------------K---S----LQNSNP
EQDLKMTSDKED----------------------PGRVA--------EKMKTCR------
---------------------------NKKMEVS---RNLHANYSDS-------------
-----DLDELIQ---------ERRSRKPD----NHQFPRQKSEEN---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------NGLAKKSSNKKNK---VKRHLYFKD--------
------------------------------------------------------DL-DDI
IRSSETASEKDELP--YSDDMNFMLLIEQHR---KE--CKD--FVSLLKIKNA----ISA
HERLIEH---KIHY-------------------CEQLTVKFQKMKNE-------------
--ISKLR----KELSEID---KTKSQIEHQKPD-WKQEL--HILRLILQQQEEKRRK-PE
KY-EKGIEK----FKIMEEQ------------------YWTQARVKNLLKLTHKSLNIEL
KTVRNNLN-QSS------------------------------------------------
--------------FTHEKERD---LWQK------NHLMRVEIARLRLEIDTIKHQNQEI
ENMYFKDIEIIKKKNEDLEKTLKLNEETLT--------KTINWYSEELNGLTL------D
KNTVLNSE-----------------------------------LEKEKQRK---------
--QRLETELELYSRRLAAALCDR--DQSQSSKRDLQ----LAFQNTVNQWCHLQENMNSH
I-------QILS--------------------------Q-QLSKAESKSRG--LETELHC
ER-EALKEKTLA-IEH--MQGVI--SQAQCRMKA-----FEHMYQN-DQHIV------EK
YVRKQQSVQDGLFQIQSQNSLHQQQLNDAHKKA---DNQEKTIIDIQA----KCEDTVEK
LQAEC-RKHCILLEENNKGLIEEY-TLLKERQCQYEKEKEEGQV--VVRKLKRELGDV--
--LNKQ------SLAEGMLEISSQRQNTLEDETRDTKKKLELMRSQ-VCMKLSLSTVTL-
------------------------------------------------------------
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------------------------------------------------------------
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-----------------------------

---------------------------MSD------------------------------
--------------------------------------------------------DERE
RWPT--------------LM--------------------------ERLLSDGFAFPHYY
IKPYHLKR-----IHR---------------AVFYGNL----------------------
AK---LKYLLLMHY--D--PNRR-DRK------------------ERTAL----------
----------HLAC--ATGQPEMVHLLVSRRCELNL--CDREDRTPLIK-----------
-AVQLRRGACATLLL-QNGADPNIMDVF----GR--TALHYAV-YNEDTSMIEKLLSHGT
NIEECSKN-E---YQPLL------LAVSRRKVKMVE-FLLKKKAN--------VNAI---
-DYLGR-------SA-LILAVT--LGEK--DIVILL------------------------
---L-QHN-IDV--------FSRD------VYG-KLAED---YA-SE---AEN---RV--
--ILELINEYKRKK-LEELSINS-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------N--------------
----------PG--EI--S-------------------------DSELLLM---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-----------------------------------------------------VLP----
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-----------------------------

------------------MKKLFSFWVKGK------------------------------
--------------------------------------------------------TDDS
-------------------HSRSSEL-----SM----------SMASTD-PSLSTSRGHH
LQDKPLKK-----LHK---------------AASVGNV----------------------
QK---FKKYLECKK-HD--VN-GRDKK------------------SRTPL----------
----------HLAC--ANGYIDIVYLLIENQCKINV--QDSENRTPLIK-----------
-AVQCQQENCAMVLL-QHGADPNLVDFN----SN--TALHYAV-CGQNISLANELLEYKA
NLEAKNKD-G---YTPLL------LAVAENNVNMVK-FLVKKGAD--------VNAS---
-DNNHR-------TA-IMIALT--VEPT--NSVKL-------------------------
--LL-QQD-MNL--------SCRD------IYG-FTAEE---YA-SF---NGF---TM--
--YHQIIANNGTKKKT--KSTAD-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-----------------------------

------------------------MKRSSG--FGGQ------------------------
--------------------------------------------------------KGQG
PSGS--------------FTCWWCCRGDDV----------------AEHDDSPFTQCRYN
IREKHLGK-----LHR---------------AASRGEV----------------------
SK---VERILSRG-NAD--LD-ERDKK------------------KRTAL----------
----------HLAC--ANGHPEVVALLVDRGCQLDV--FDNKNRTALLK-----------
-AVQCQEEECATILL-EHGADPDLPDVY----GN--TTLHYAI-YNEDIPMTKKLLLYHA
NIESANKD-E---LTPFL------LAVHEQKQQMED-FLRKQKEN--------LTAV---
--KLES-------IH-QV------------------------------------------
--MS-EYK-ENE--------TPRN---------------------PQ---NSN---PE--
------------------------------------------------------------
-------------------------------------------GT------S--------
--------N---------------KMAY----------L---------------------
------------------------------------------GEGAA--G-AK-------
--VNEIPGNPVKRLFN--K--------------PSVD---D---SRPMSAN----EDF--
-----------DFDTEE-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------KATEPANGKR------Q---
---NGMGIIE----SAPQEHT---NNENLI------------------------LIQKCS
RW----------------------------------------------------------
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-----------------------------

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---------------------------------------------------MKKKQMLIC
CT-KKRREE----FERKEKP------------------CKKEVEAK-QLGPTVQSREMKP
ETLRSTPN----------------------------------------------------
----------Q-DFHNQEEMKD---LMGE------NCILKTSIAVLRQEICTMKNDNLEK
ESKYRKDIKIVKDINAALEKSIKLNEEMII--------KTAFQYQQELSDL-KT------
ENTRLNSK-----------------------------------PLKEKESK---------
--ERLQAEIESYQSRLSAAISKH--GESMKTERNLR----LPLERTQDV--SLQVKMSSD
TSKVEDKNEFLT--------------------------Q-QRSKRQIKFNT--LKDKFHK
TR-DTLRKNSLS-SET--VQNYL--SQTAANKRN-----EKD-VSN-AGAKV------SK
STGKWNCVEEKICQLPGENSWLEQQLDDVHQKD----NHREIVINSQE------------
------------------------------------------------------------
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-----------------------------

-------------------MRLFGTRTEP-------------------------------
----------------------------------------------------------PE
TCGP--------------TSPRR-----------------------DVGINGATAKDGYR
IRKKFLGK-----LHR---------------AALSGDC----------------------
RK---IQWLLLAKG-KD--IN-KVDDL------------------NRTAL----------
----------HLAC--AAGYPDVVSFLVERHCKLDV--CDSNHRTPLMK-----------
-AVQCQQEECVSILL-LHGADPNMVDES----SS--SALHYAA-AGGNLRIVERLLESKA
NMEARDKQAC---LTPLL------LAVKNHHEAMVD-LFLKNGAN--------VNAK---
-DNSKR------------------------------------------------------
------------------------------------------------------------
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-----------------------------

MAA-----EVCSRSAASTVKKPFGLRSKMGKRC---------------------------
----------HHCFPCCRGSGKSNVGTSGDHDDSTVKVLRSKMDKWCCHCFPCCRGRGKS
NMGTSGDHDDSAVKTLRSKMGKW-CRRCFPCCRGRGKSNVGSWGDYDD---SAFMEPRYH
VRREDLDK-----LHR---------------AACWGKV----------------------
PR---KDLIVMLRD-TD--VN-KRDKQK------------------RTAL----------
----------HLAS--ANGNSEVVKLLLDRQCQLHV--LDNKQRTPLIK-----------
-AVQCQEDECALMLL-EHGTDPNIPDEY----GN--TTLHYAI-YNEDKLMAKALLLYGA
DIESKNKH-G---LTPLL------LGVHEQKQHVVK-FLIKKKAN--------LNAL---
-DRYGR-------TA-LILAVC--CGS-A-SIVSL-------------------------
--LL-EQN-IDV--------SSQD------LSG-QTARE---YA-VS---SHH---NV--
--ICQLLSDYKEKQMLEISSEN--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------SNPEQ-----------
---------DLKLTSEE------------------ESQ------------RLK-------
--------------------------------GSENR-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------QQE--------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------KISQAPEINK-----------
---DCDREVE--------------------------------------------------
---------EEMKKHG--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----SNH------------------------------VGFP------------------
------------------------------------------------------------
-----------------------------------------E-------NL---------
--------------------------------------------------TNG-------
------------------------------------ASA---------------------
---G---------NG---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------D-DGLI---------------------------P----
----Q-------------------------------------------------RKNRTP
----------------------------------------ENQ-----------------
--QFPDPE------------------------------------------------NV--
------------------D-----------------------------------------
----------------------------------------------------YH------
-RICQLLSDCK-------------------------------------------------
------------------------------------------------------------
-----------------------------E------------------------------
-------KQMPKYSS---------------------------------------------
------------------------------------------------------------
-------------------------------ENSNPDEQ---------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------NDIQKQLSEEQNTGILQDEIL-----TK---S--EQKQEVAE---
-KKMNSE-----------------------------------------------------
------------------------------------------------------------
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-----------------------------

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---------------------------------MVK-FLVGKGAH--------LLSG---
-DTVKS-------SD-QLISEH--EEEM----KPENSSQN--------------------
---------HDL--------VAKK------SE----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------EVSLSSRTR--KADT------------------DD--SRPSKHEDL-------
---------TSGTKE-------GATKPA-----------IGKKDNGID------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------IIESPPQ-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------EQA--------------VNDNLT-------------SADRAH
KNH----MSDRISALGRGED---SSPWDSESI-SASLPKKSVD--C-------------L
PGGA--------------------------------------------------DQ----
------------------------------------------------------------
-------------------------------------------QG-----QSILNEQV--
EE---SPGK------DL---HW-KSTTEVKDS------VTNEAV----------------
----------------------------------------AGK-----------------
------------------------------------------------------------
---------------DQ----QMS------------------------------------
-------RSDFS------DWDSSLS----------------LG---NE------------
------TCQRTGDL----------------------------------------------
----KVDDKCP------------FVSQPMTK-I-------------------------E-
--SASGEFGQT--------------------------------------------TLMDK
------------------------------------EN--INIGAVFLLEN-----S---
TLH-DL------------------------------------------------------
----------------------------------CE-SE-L--PE-NRESK---------
KDLSA---ELDLEVA-SEE-----EQ-----ER-PDESENNHPQIEKKRKKQ---KSSKM
EGAE-----------NIYAA----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------AAAGL-IQQR----------
--KNGK------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------TDNHLFPTMKNEDS---------------
-------DA---------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------PAKKMSKEKNK---VKKQMNSVE--------
------------------------------------------------------HL-DDL
TQSSEAPSEDCKLH--YSDFKSSLLLIEQLG---MD--CT--DSVSLLKIQDA----ILS
YERLIEL---KKND-------------------CEQLIRRIKKMGCK-------------
--INGLQ----KELSETK---EMKSQLEHQKVE-WEQEL--CSLRFTLKQEKEKRKSADM
LY-EKIREQ----LRNKEEQ------------------YSKEVEMKQQLELNLRTLDLEL
KSVKNNLN-QVIEERNDIQRQLSQEQNARILQDGIL-----NNHLCK--RKEIE------
--ISHTKMNSE-ASPTHEKAKD---LLHK------NRMLQDEIAMLRLEIDTIRNQNQEK
EKKYCEDIEIEKEKNDSLQKTIKLNEVTLT--------NTVFQYTGQLNVL-TT------
ENTMLHSQ-----------------------------------LDNEKQNK---------
--ERLEAKIQSYRARLATAIQDH--DQSQASKRDLE----LAFQRAKDEWFRLQDKMNFD
VSNLKDNNEVLS--------------------------Q-QLSKAESKFNT--LEIELHH
TR-DALREKTLA-LEH--VQRNL--KQTQCQKKE-----IEQKYQN-EQSKV------NK
YFGKQGSLEERLSQLQSENMLLRQQIDDAYSKV---DCKEKTVIDIQD----QFQVIVRN
LQAES-EKQSVILQERNKELITEC-NHLKERIYKYEKEKEER EV--VMRQFQQELADA--
--LKKQ------SMSEASLEVTSHYRINLEDEVQDLKKKLDQIKSQ-LREAQDRYTEAVG
CIEK-----------------------------------SQDHIQKLEVENAKLKVTIKK
QAGQIEQLQ----EDLLSPSSPS-------------------------------------
-------------------------------DE---KE-SLKKC---MELKQSLEFS-LD
QEVKKNYELEKENTGFKN-----LLNMTR--------------RMLSK------YENGE-
---L-PFYGDLKTSQTEMDIQINMLKHKIDDLTAKLETESSRCLHLDAK-----------
-NQVL--QQELLSMKATERKCEKLEKNKKKLEQKVVNLRSH---LEV-NVVERSQVEKY-
KREIEERARLVI-VEKLKEVNL---FLQTQAA-SQENLEQ-LRES-NNAS IRGQLELRIK
ELESEI-SKIKNSQE--------DKAELEKYR----QLYLEESKIRMSLT-NKLSKTSER
LADITTKYLVEKQQ---NRPFHS------TLTMRPVLELPYVGNLTSSLLLDRNVTPREN
VVI-PTSSSRPSNNS-IDTYLTKMQQMLEENITRELKEA-AGE-----LES-----G---
--------------------SCRSFSLGST---------DES----NLNQHLVLQASQEY
VEILKKN--YMI------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

--------------MSFSMKKIFG----AK------------------------------
---------------------------------------------------------EKT
PLGF--------------CDAPQMTVSEFFF--------------GE-----SPNYPKYH
TTYRPLGH-----IHR---------------VAAEGDA----------------------
AQ---MEILLTLG-QCN--VY-HRDRK------------------DRTAL----------
----------HFAC--VYGRLPVVTILVKNNCEIDA--LDKNHTTPLMK-----------
-SVQCWKQKCATVLL-EHGADPNIRDSS----GN--SALHYAV-YNGHEEMASLLLQYNA
DIEQKTKD-G---FTPLL------LALREKRVELAE-FLVRMGAD--------IHVV---
-DELQR-------NT-LIYAIR--CGSK--DLSVL-------------------------
--LL-EKG-IDF--------FYKD------VFG-WTALR---YA-IE---GHC---T---
--FRQTLLDFEENLHCNKKDKEPELQVEPNTSCILAK--------QIDAGNDSLARISS-
CPNPETPVLTMKED--ENSDARSN------SESKPPNCAGNSLAAIDKIHGNRGKRTVEA
W------VEKDPSS----------ESAAEVRD-----SVTNEAVERIKLLPSE-------
-------TELEL-----------------------------MSVE-DVSRESEND--HPS
RDSEHLPKIKVGHSSR--SGYQ-----------MGKM---NI--NRQMKGRI--NIFI--
-----------IFLLKI------------------YVITYLFKTG-HCYM-IL-------
-------------KYY--------------------------------------------
------------------------------------------------------------
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-----------------------------

------------MGVGGSFLRT--------------------------------------
------------------------------------------------------------
-------------------CGGCVAPWRENR----------------G--KDGFSNPGYR
VRQKDLGM-----IHK---------------AAIAGDM----------------------
NK---AQESILLRL-ND--VN-DRDNK------------------NRTAL----------
----------HLAC--AHGHPRVVADLVARKCQLNL--TDSENRTALIK-----------
-AVQCQEEVCACILL-KHGADPNVRDIY----GN--TALHYAI-DNENISMAGKLLAYGA
DIEAKSQD-E---YTSLL------LAINRKKEQMVT-FLLKKKPD--------LTAI---
-DNSGR-------TAL-ILAAC--NGS-------------------TG----------VV
FQLL-QHN-VDV--------CCRD------ISG-WTAED---YA-VA---YNF---Q---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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----------------------------------------AIRR--------------LI
SEYK--------------------------------------------------------
------------------------------------------------------------
-----ANK-------------------------------RR-------------------
------------------------------------------------------------
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------------------------------------------------------------
---------------------------------------------K---R----LQNRNP
EQDLEMTSEGEQESLEG-------------CESSQPQVE--------EKMKKCR------
---------------------------NKKMEVS---RNVHADDSDNY------------
---NDDVDELTH---------KIKNRKPD----NHQLPRKENDKF---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------DRLARKTSNEKNK---VKSQIYFRD--------
------------------------------------------------------DL-NDV
TGSSKKTSEDDDLP--YSDDKNFMLRIEQHG---ME--CKD--FVSLLKIKNA----IAA
CERSREH---KKCN-------------------CEQLKVKFQKMKNK-------------
--ISMLQ----KELTETD---KTKSQLEHQNLE-CKQKL--CNFSCVLQEEEEERRKAEE
LY-EKDTEE----LKIMEDQ------------------YRTQTEVKKRLQLTVESLEVEL
KTVRSNSN-ESS------------------------------------------------
--------------HTHEKERD---LWQE------NHLMRDEIARLRLEIDTIKYQNQET
EKKYFKDIEIIKENNEDLEKTLKLNEETLT--------KTITRYSKELSAL-M------D
ENTVLNLE-----------------------------------LEKEKQST---------
--QRLKTEMELYPCRLAAALHDH--DQCQSAKRDQQ----LAFQSTVNEWCHLQENINSH
I-------HILS--------------------------Q-QLSEVESTSSG--LETELHY
ER-EALKEKTLA-IEH--MQGVL--SQTQCRLKD-----IEHMYQN-DQPIF------EK
YVRKQQSVEDGLFQLQSRNLLYQQQCNDAHKKA---DNQEKTIINIRA----KCEDTVEK
LQAEC-RK----LEENNKELMKEC-TLLKERQCQYEKEKEEGEV--VMRQLQREVGDT--
--LNKQ------SLSEAMLEISSQCHHNLEDETRDSKKKLDQLRSQ-VCMKLSMSTVTL-
------------------------------------------------------------
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-----------------------------

------------------------------------------------------------
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------------------------------------------------------------
-----------------L------VAVAENKQQIVE-ILMERGAN--------IHAI---
-DRWKR-------TA-LMLAVT--YECT--DIVKL-------------------------
--LL-QKG-INI--------FLEA------ECG-WTAEE---YA-TV---SGF-------
------------------------------------------------------------
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-----------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------AC--ALGHVEVVTLLVSRKCQIDI--DDRLNRTPLMK-----------
-AVHGQEEACSIILL-EHGADPNIQDVY----GN--TALHYAV-YNSVTSLAEKLLSYQA
NIEAINKE-G---NTPLL------FAITCKRQQMVT-FLVNNQAN--------VHTV---
-DNFRR-------TA-LMLAVH--HNLP--SIVNL-------------------------
--LL-EEN-VSV--------FSQD------MFG-QTAED---YA-VC---CDL---VR--
--IQQQILEHKNKKLKN-LQDDN-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------R--------------
----------E----T--A-------------------------AT--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------K-------------------------------------------PT-------
------------------------------------------------------------
-------------------------------------------------HF--K------
------------------------------------------------------------
-------------K----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------MKK
------------------------------------------------------------
----------------------------AF-------ILTKHMDF---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------SVEHDLKVASEETEERLKR--SQNIQPQDF---------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------QSHGRKKD---VMYE------NCMLKRDTAVLRRKLHTIKNASLRK
EKEHIQEIKRIKEINANFRKSVRLNEEMIT--------KTISQYCQRLHEL-K------A
KNTRLNSE-----------------------------------LEKEKHSK---------
--DRLETEIESLHSILSAAVNEH--NERAKT-KFLQ----VALQRAQDVSV--QEIMTSN
ISQLKDKNELLT--------------------------G-QLSKGRMKFST--LKEKLQE
TR-DALREKTLA-LES--AQRDL--RQKQHRIKE-----MEQMHLN-EEAKE------SQ
FIGKQNSAEERIRQLERENLLLEQLLLEAACKK---GNNENIVINIQG----GCL-----
---ES-EKEDLLLEEKNKELTNEY-NYLKEKLFQYEKEAAE IKV--IVRQLQEELAGS--
--LKKV------SMPESPLEGTSHCHINLDE-TWASKKKLFEVGNQ-SEEK-EELR----
------------------------------------------------------------
-------------K----------------------------------------------
-------------------------------------------L---FELISSQEYN-MD
QIRKKNNELEEETTGYKKL-----LEMTI--------------SVLNV------FGNE--
--DF-SFHGDLETDQLKMDILIKKIKQKLDDLIAEKEAVSSKCINLDKE-----------
-NKVI--QQELLSMKKVQEKREKLE-DKKMLEEELLNLKTH---MDT-NMVEVGEVREY-
KLEVEEKAMQAI-KNLEET------HLQKQAD-YEKQLEQ-LNKE-HTASQ-NEMELKIK
DVKCKL-SEMKTAYEE-----V--TNELEEYK----EAFAVTLKANNSMS-KKIHEVK--
--NGSTKLLMEKVR---MKSCLS------ILPMRPDPKSPHVKNLSSIE-CNRKYIPETS
GKI-PTSDPQTSNNW--KNYLTG-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------------------------------------------------
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-------------------------------------MLQDELAMLRLEIDTIRNQKQ--
EKRYCEDTETEKEKNDSLQNAIKLNE----------------------------------
---------------------------------------------DEKLNR-----------ERLEAKLQSYRARVATAIQDR--DQSQASKRDLE----LAFQRAKDEWCHLQDKMNFEMSNLKDNNEVLS--------------------------Q-QLSEVESKLNA--LEIELQYTR-DALREKTLA-LEH--LQRNP--KQTQGQKKE-----IEQKSQN-EQGKV------NEYMGKHESLEEKLSQLQSENMLLREQLDDAYSRV---ECKEKTIIYLKD----QVQVIVRMVRVAG-EKRALQLRERNKELINKC-KQIMERAFRYEDEKEERER----------------------------------------------------------------QEAKELQTKVV----------------------------------------------RLEVENAELKVTVKEQAGQIEQLQ----KDLLSSSSCGDE-----------------------------------------------------------------KEN---L----KKC---MELKQPLQFR-LDQEVKKNEELEKENTG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DEKLNR---------
--ERLEAKLQSYRARVATAIQDR--DQSQASKRDLE----LAFQRAKDEWCHLQDKMNFE
MSNLKDNNEVLS--------------------------Q-QLSEVESKLNA--LEIELQY
TR-DALREKTLA-LEH--LQRNP--KQTQGQKKE-----IEQKSQN-EQGKV------NE
YMGKHESLEEKLSQLQSENMLLREQLDDAYSRV---ECKEKTIIYLKD----QVQVIVRM
VRVAG-EKRALQLRERNKELINKC-KQIMERAFRYEDEKEERER----------------
------------------------------------------------QEAKELQTKVV-
---------------------------------------------RLEVENAELKVTVKE
QAGQIEQLQ----KDLLSSSSCGDE-----------------------------------
------------------------------KEN---L----KKC---MELKQPLQFR-LD
QEVKKNEELEKENTG---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

MVA-----EVGSMPAASFVKKPLGLRSKMGKWC---------------------------
----------RHSFPCCRGSGKSNVGTSGDHDDSSMKTLRSKMGKWCRHCFPCCRGSGKS
NVGTSGDHDDSSMKTLRSKMGKW-CCHCLPCCRGSGKSNVGAWGDYDD---SAFMEPRYN
VRREDVNK-----LHR---------------AAWWGKV----------------------
PR---KDLVVMLRD-TD--VN-KKDKQK------------------RTAL----------
----------HLAS--ANGNSEVVKLLLDRRCQVNV--LDNKKRTALTK-----------
-AVQCQEDQCALMLL-EHGTDPNIPDEY----GN--TALHYAI-YNEDKLMAKALLLHGA
DIESKNKH-G---LTPLL------LGVHEQKQQVVK-FLIKKKAN--------LNAL---
-DRYGR-------TA-LILAVC--CGS-A-SIVSL-------------------------
--LL-EQN-IDV--------SSQD------LSG-QAARD---YA-VS---SHH---NV--
--ICQLLSDYKEKQMLKIFSEN--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------SNPEQ-----------
---------DLKLTSEE------------------ESQ------------TLK-------
--------------------------------GSENG-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------QPE--------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------KMSQEPEINK-----------
---DGDREVE--------------------------------------------------
---------EEK------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
-----------------------------------K--QHG--STHVG------------
-------------F-------------------PENLTNGAAAGNGD-------------
--DGLIP----PRKSRTP---EGQ-----QFPD-TESEE--Y-HS---------------
------------------------------------------------------------
------------DEQNDTQKQLSEEQNTGILQDEIL-----IH---K--EKQIEVAE---
-KKMNSELSLS-----YKKEKD---LLRE------NSTLQEEIAMLRLELDTMKHQSQLR
EKKYLEEIESVEEKNDNLLKALQLNE----------------------------------
------------------------------------------------------------
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-----------------------------

------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------PTLISFPQYH
IKSSHLRR-----IHR---------------AVFNGNL----------------------
EK---LRYLLMTFH--D--ANKR-DDK------------------GRTAL----------
----------HLAC--ATGQPEMVFLLVSARCELNL--CDRECRTPLIK-----------
-AVQLRQEACATILL-QNGANPNIMDFF----GR--TALHYAV-YNEDTSMIEKLLLYGT
NIEECSKT-E---RQPLL------FAVCQRKLKMVE-VLLKKNAN--------INAI---
-DCLS-------------------------------------------------------
------------------------------------------------------------
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-----------------------------

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-------------------A--------------ARSGD-------VP-----GVEGVLA
PGD-----------------------------------TGMDKRD-GKKSIQQLVPEYKE
KQTPEILPQNNNPDWHPTNLTLSDETCQRSKNLKVDDKCPSVSPSMPENQSATKELGQMN
LTEQRKM----------NIG-VVL---------------LLGNGTSH--DLC-QSQLPE-
----------------------NKKSK---------------E------AELDLELISGE
A---QERLKGCENKQPQ----KTSQEPEMAKDCDRED------------------IPIYP
VLPHVQKSEEIWIEQGKLEWKNQLKL-----------ITNKLKQRFGE------------
------ICEKYKIP----------------------------------------------
----PCPEEEPLLDNSTRGTDVKDIPFNLTN-N-------------------------IP
GCEEEDASEVSVSVVFETFPEQKEPSLKNIIH---------PYYHPYSGSQKHACQLSSE
LHLHENKLDCDNDNKPGIGHIFSTDKN-IHSDAGTKKAR-NPEVVTVEMKE-----D---
QEF-DLQMTKNMNQNSDSG-----------------------------------------
---------------------------STNNYKSLKPKL-E--NL-SSLPPDSDRTSEVY
LHEELQ---QDMQKSKNEVYTLEEEF-----LTLKKENVQLHKAVEEEMEKH---RSNST
KLSG-----------TLTDGATVG------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------SDDDGL-NQQ-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------IPRKE-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------NGEH-DRPADKTSNEKNE---VKNQTH-----------
---------------------------------------------------PEADF-ADS
MEPSEIASGDCELS--HSVCENFILLIEQLQ---EE--CKD--SVSLPRIQDT----FCL
WEHLLKC---NNNH-------------------CDQLTVKIKQMENM-------------
--VSVLQ----NELSETK---KTKLQLKLQKIE-WEKKL--YDLRLALKQEKVEKRNAYM
LY-NKDSEQ----SRIKEEE------------------CGKVVETQQQLKWNPSRLVKKL
RTVRNNLD-LVVQERNDAQKQLSEEQNARISQYQIL-----MS---K--QKELE------
--MAQKKINSE-ISHRHQKEKD---LFHE------NCMLQEEIALLRLEIDTIKNQNKQK
EKKYFEDIEVVKEKNDNLQKITKLSEKTLT--------ETILQYSGQQNNL-TA------
ENKILNSE-----------------------------------LENGKQNQ---------
--ERLEIEMESYCCRLAAALG--DCDQSQT-ARDLK----LDFQRTIQEWIRLHDKMKVD
MSGLQAKNEILS--------------------------E-KLSNAESKINS--LQIQLHN
KR-DALGRQSLI-LER--VQRDL--SQTQCQKKE-----IEQMYQI-EQSKL------KK
YIAKQESVEERLSQLQSENTLLRQQLDDAHKKA---NSQEKAISTIQD----QFHSAAKN
LRAES-EKQILSLQEKNKELMDEY-NHLKERTDRCEKE K-GRKV----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------DLTEAQETVPSRCLHLDAE-----------
-NEVLQLQQTLFSMKAIQKQCETLQKNKRQLKQGIVSLKSY---MER-NMLEHGEAEQH-
KLLIEERARKEM-EEKLNEAIL---TLQKQAAVSQEQLAQ-LRED-DTTSI KTQMELTIK
DLESEI-SRIKTSQADF------NKTELERYK----RLYLEEVKVRESLS-NELNRTNEM
IAEVSTQLTVEKQQTR-SRSLFT------AYTTRPVLESPCVGNFNDSEGLNRKHIPRKR
SSA---------LKS-MESYLLKMQQKLENDLTTEVAGS-SQTGLHRIPQC-----S---
--------------------SFSSSSLRLLLCSICQPFFLVLQLLLNMNLDPI-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------MKKIF------K------------------------------
---------------------------------------------------------GHL
PW----------------------DFLGFRN--------------AN--A-ENQEWHRYL
TGYIPVKK-----IHK---------------AASMGDI----------------------
TQ---VQRMLEFG-DVD--VN-VTDRK------------------KRTAL----------
----------HYAC--AHGQAEMATLLLWYECNIEA--RDSDESTALIK-----------
-AAQRQHEACVKVLL-ENGADSNAIDAD----QN--TALHYAV-YNNSTSIAAKLLEFRA
DTEIKAKN-G---YTPLI------LAVLKNKLEMVE-LLLRGAAN--------INAL---
-DNYKR-------SA-LIHAVR--AQCR--DMIGF-------------------------
--LL-QQG-ADV--------SLVD------VYG-ATAQS---YT-GF---ETF---Q--V
LSK---------------------------------------------------------
GPSS-----TTREDRYS-SD----------AKEDCLSCAQSTQEDGTREEGNRGAADKLG
--------------------------------------RY--------------------
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-----------------------------

------------------MKKIFGFRT-KG------------------------------
--------------------------------------------------------PVPL
GSSGG-------------A-RPRRSSAGFGS----------------GTA-KNPGAPGYS
VHDKDMGK-----IHK---------------AASVGDV----------------------
AK---VQHILLLGK-NG--LN-DRDRR------------------NRTAL----------
----------HFAC--VFGHSEVVTLLVERKCEIDA--CDNENSTALIK-----------
-AVQCQEEECVTILL-EHGANPNIPDAS----GN--TALHYAV-YNENIQIAAKLFAHDA
DIEARNKD-D---LTPLL------LALREKKQQIVE-FFIRNKAK--------TCAV---
-DELES-------KR-QVFSDC--EEKR---LK-NSENGHSANELNVSI-------FITY
F-----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------CSKNRLSNT--PPGP--------------G----D--PWPSSDE---------
--------DDYDFDNKN-------------------APKVNLKDLWTAAQQSRKN----Q
TRCDFRKV------------------ETRTLFDNNNSDNE--------------------
---------------------K-------------------EDVV---------------
------------------------------------------------------------
-----------------------------ELLPK--------------------------
----------------------------------TSVKVQSFSLPS--SLSPDP------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------MEGKTEPAIGKGE---------
---NDTNIIE----SASQE--------------LVNNDN-------------LTHVDGRH
RNN----KTEMMSALGLGDE-DEDSPWDSESV-SESLPLKCAG---------------YL
SGDADPRGKNTVNE---Q------VED----------------------------MVYIP
SCMSGSRNFKMAKLEDSRNV--------------DKRVAPMGMEKMVDYVNYY----STS
------------------------------------------------------------
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-------------------------------------V---------EGK----------
------------------------------MNLK----------SKES------------
----QLSANLNQ---------ERKSTKTD----KQQFPFKDNEKY---------------
---------DGSGTALHMKK-VKKMEK--EKWTSRESMIMLMCEKSGLG-----------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------TDGLLYVKDEKDQDE-
------------------------G----------RPTKN---VKNPINEMD--------
------------------------------------------------------DFDDDL
TQSSETVSEDYDLP--HPTYENIVLLIEQLR---ME--CKD--FVSLLKIRDA----VHS
YKRWIEL---KKSQ-------------------CDELSGKIKRMEIR-------------
--IRGLQ----KELSEIK---EEKSQLEHEKVE-WEQEL--CKLRFALKQEEEKRKSAEQ
FY-EKIKDQ----LRKSEEQ------------------YNKEVEMKQQLEVSVRTLDMEL
KTVRNNLN-QVVEERNDAQRQLSREQNARLLQDGIL-----ANHLCK--QKEKEMMQ---
-KKMNAEVSF-----SHEKEKD---LLHT------NHRLQDEIAMVRLEIDTIRSHNQEK
EKKYLEDIEIANEKNDNLQKTIKLNEETLT--------KTVFQYNGQISIL-T------A
DNAMLNSK-----------------------------------LENEKQNR---------
--ERLETEVELYRTRLAAAINDH--GESQTSKKELE----LAFQRARDEWSRLQDKLNFD
ICNLKDNNEVLS--------------------------Q-QLSKAERKFNS--LETELYH
TK-DALREKTLI-LEH--IQIDL--TQTQSQMKE-----IEHMYQN-EQGKV------NK
YIGKQESIEERLSHLQSENTLLRQQLDGAHHKV---DSKEKTLINIQD----QFHDIIKK
LQAES-EKQSLMLEDRNKELINEC-DHLKERLHQYEDEKAER EV--VVRQLQQELADT--
--LKKQ------SMSEASLEVSSRYRLNLENETQDLRKKLDQIRSQ-LQETQDQHTEAVR
C-----------------------------------SEKMQDHVQKLELENSKLKVTLKK
QSGKIEELK----KTLLNA-----------------------------------------
------------------------------DLSEDKKK-QLKRL---TELKQSLEDT-LD
QEKKRSGELEKELTGFKKL-----FKMTK--------------KKLND------HESG--
--DF-SLLEDLKSSQFEMDIPAIMLMQKIDDLTAKLETASSKCLHLDKK-----------
-NQFL--QQELLSMKTIQNKCEKLEKNKKKLEQRIVNLKSH---IEN-NMMENGQVEQY-
TREIEEKARQDL-VDKLKQVNL---FLQTQAA-SQENLEQ-LREN-NNASV RSQMELRIK
DLESEL-SKMKT-QD------DFNKIEIEKYK----QLYLEEFRSRKSLS-NKLTKTNER
LEEANTKLYVEEQQ---NRSLLS------TLSARPILDCPCVGNLHNTLALNRSFIPTES
LVL-PTLTSQPSSKS-MENYLTKVQQELEKSITRELKEA-AAE-----LES-----G---
--------------------FFRASPLGST---------PKS------SQNLKSEASQGY
IEILKKK--YMI------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------MKKFFLFRGKRK------------------------------
--------------------------------------------------------TDDS
-------------------HSHSSEV-----PI----------SLAKTAPPSLSIGGGYH
PRDKHLKK-----LHK---------------AATTGNE----------------------
QK---LKDYLERKK-YN--VN-GRDKR------------------SRTPL----------
----------HLAC--ANGYTNIVSLLIENQCKINV--QDSENRTPLIK-----------
QAVQCQQESCATVLL-LHGADPNLVDVY----SN--TALHYAV-CGQNISLANKLLQYKA
NLEAKNKD-G---HTPLL------LAVAENNENMVK-FLLKKGAD--------VNAS---
-DKNHR-------TA-IMIALI--VEPT--SSVKL-------------------------
--LL-QQD-TDL--------AHKD------IYG-FTAEE---YA-SF---NGF---TM--
--YHQITANNENKKKT--EQTAY-------------------------------------
------------------------------------------------------------
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-----------------------------

------------------MKKIF---SKKG------------------------------
--------------------------------------------------------ESPL
GSFA----------------RRRRSSAGGGG----------------EPGEGAYSQPGYH
VRDRDLGK-----IHK---------------AASAGNV----------------------
AK---VQQILLLRK-NG--LN-DRDKM------------------NRTAL----------
----------HLAC--ANGHPEVVTLLVDRKCQLNV--CDNENRTALMK-----------
-AVQCQEEECATILL-EHGADPNLADVH----GN--TALHYAI-YNEDIPVATKLLLYDA
NTEAKNKD-D---LTPLL------LAVNGKKQQMVE-FLIKKKAN--------VNAV---
-DKLES-------SH-QLISEY--KEER--IPKNSSQNSNSVSQDCI--TK-CFFGFFFS
R------W-SFT--------LVAQ------A-----------------------------
-----GVQ----RHDLSSL-QPP-------------------------------------
LPG---------------------------------------------------------
---------------------------------------------------FT-------
-------Q----------------------------------------------------
FSCLCLPSSCDHRLSG--KPGV--------------D----D--SWPTSDD---------
--------EDLNFDTKN-------------------VPKPSLAKLMTASQQSRK---NLE
ATYGIVRT------------------GSRTLFEDRDSDSQ--------------------
---------------------D-------------------EVVV---------------
------------------------------------------------------------
-----------------------------ESLPT--------------------------
----------------------------------TSVKAQGFSHPT--CQSPDPLP-KPS
HKS---------------------------------------------------------
----------------------------------------LANP----------------
-----------------------------------GLIKNPVDLIFYKC-----------
--------------------------------------S-------------HA---YIC
VSH----LIDMMSALGLGQEEDIESPWDSESI-SENFPQKYVD---------------PL
AGAAYRKEKNIGNE---Q------AE----------------------------------
-----------------------------------------ESPERYLHLKPA----IEM
-KDSVPNK-----------------------------AGGMK------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------DV------------------
---------------------------------------------QTSK-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------AA
EHDLEVASEEEQER-EE-------------SENHQPQVE--------EERKKHR------
---------------------------NSEMEIS---ANIHDGATDD-------------
-----ENDGLIQ---------ERRSGETD----HQQFPRKENKEY---------------
---------ASSGPALQMKE-VKR--------TAKESVNSPVFEKAGLL-----------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------TGGLLQV---------
--------------------------------------------KNQIQSMD--------
------------------------------------------------------DV-DDL
TQSSETASEDCELP--RSSYKNFMLLIEQLG---ME--CKD--SVSLLKIQDA----ALS
CERLLEL---KKNH-------------------CELLTVKIKKMEDK-------------
--VNVLQ----KELSETK---EIKSQLEHQKVE-WEREL--CSLRFSLNQEEEKRRNADM
LY-EKIREQ----LRRKEEQ------------------YRKEVEVKQQLELSLQTLEMEL
RTVKSNLN-QVVQERNDTQRQLSREQNARMLQDGIL-----TNHLSK--QKEIEMTQ---
-RKMNSENSH-----SHEEEKD---LLHK------NSMLQEEIAMLRLEIDTIKNQNQEK
EKKCFEDLEIVKEKNEDLQKTIKQNEETLT--------QTISQYNGRLSVL-T------A
ENAMLNSK-----------------------------------LESEKQSK---------
--ERLEAEVESYRSRLAAAIHDR--DQSETSKRDLE----LAFQRARDEWSRLQDKMNFD
ASHLKDNNEILS--------------------------Q-QLFKTESKLNS--LEIELHH
TR-DALREKTLG-LER--VQKDL--SQTQCQMKE-----MEQKYQN-EQVKV------NK
YIGKQESVEERLSQLQSENMLLRQQLDDAHNKA---DNKEKTVINIQD----QFHAIVQK
LQAES-EKQSLLLEERNKELISEC-NHLKERQYQYENEKAER EV--VVRQLQQELADT--
--LKKQ------SMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQ-LQEAQDRHTEAVR
C-----------------------------------AEKMQDHKQKLEKDNAKLKVTIKK
QMDKIEELQ----KNLLNA-----------------------------------------
------------------------------NLSEDEKE-QLKKL---MELKQSLECN-LD
QEMKKNVELEREITGFKNL-----LKMTR--------------KKLNE------YENG--
--EL-SFHGDLKSSQFEMDIQINKLKHKIDDLTAELETAGSKCLHLDTK-----------
-NQVL--QQELLSMKTIQKKCEKLQKNKKKLEQEVINLRSH---IER-NMVELGQVKQY-
KQEIEERARQEI-VEKLKEVNL---FLQAQAA-SQENLEQ-LREN-NFASM KSQMELRIK
DLESEL-SKIKTSQE------DFNKTELEKYK----QLYLDELKVRKSLS-NKLNKTNER
LAEVSTKLLVEKQQ---SRSLFT------TLTTRPVMEPPCVGNLNNSLDHNRKLIPREN
LVI-SSSNPRTSNNS-VENYLSKMQQELEKNITRELEEA-TAE-----LES-----G---
--------------------S-IASPLGST---------DES----NLNQDLVWKASREY
VQVLKKN--YMI------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

--------------MSFSMKKIFG----AK------------------------------
---------------------------------------------------------EKT
PLGF--------------CDAPQMTVSEFFF--------------GE-----NPNYPKYH
TTYRPLEL-----IHR---------------VAAEGDA----------------------
AQ---MEILLTLG-QCN--VY-HRDRK------------------DRTAL----------
----------HFAC--VYGRLPVVTILLNNNCEIDA--LDKNHTTPLMK-----------
-SVQCWKQKCATVLL-EHGADPNIRDSN----GN--SALHYAV-YNGHEEMASLLLQYKA
DIEQKTKD-G---FTPLL------LALREKRVEVAE-FLVRMGAD--------IHVV---
-DELQR-------NT-LIYAIR--CGSK--DLAVL-------------------------
--LL-EKG-IDF--------FYKD------VFG-WTALR---YA-IE---GHC---T---
--FRQTLLDFEENLHSNKKDKEPELEVEPNTSCILAK--------QIEAGNDSLARISS-
CPSPATPVLTRKEE--ENSDARSN------SENKPPNCAGNSPAAIDKIFGNRGKRTVEA
W------VEKDPSS----------KPVTEVRE-----SVTNETVERIKLLPSIS------
------ETELEL-----------------------------MSVE-DVSDEGEND--QPL
SESEHLPQRKVGHSSG--AAYQ-----------VGKI---NI--NRQMKGRN--SI----
-------------LLKI------------------YVITYLFKTG-HCYM-IP-------
-------------KYY--------------------------------------------
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-----------------------------

MGA-----EVSPKPSAPPLKKPFGLRSK--------------------------------
------------------------------------------------------------
-------------------MGKW-YCLCLPCCWGSGKNNVGAWGDHDD---SAFREPRYH
VRREDLGK-----LHR---------------AAWWGKV----------------------
PR---ADLIVMLRG-PG--VN-KRDKKK------------------RTAL----------
----------HLAC--ANGNPEVVKLLLDRQCDLHV--LDSKKRTALIK-----------
-AVQCQEDECALMLL-EHGTDPNIPDVY----GN--TALHYAV-YNEDKLLARALLLCGA
DTESANKS-G---LTPLL------LGVHGQKEQMVK-FLIKKKAN--------LNAL---
-DRFGR-------TA-LILAVC--CGS-A-SIVSI-------------------------
--LL-QQD-VDV--------FSQD------ASG-WTAED---YA-AS---GHH---DI--
--ICQLLSDYKEKQMSKNSSQN--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------SNPGK-----------
---------EAEE-----------------------------------------------
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-----------------------------

------------------MKKLLSLWRM--------------------------------
--------------------------------------------------------KDES
-------------------LSRSSDL-----SL----------SLGSTY-SDLSTDESYN
FQHKHSKK-----LHK---------------AASVGDL----------------------
EK---LKEYLKYKK-HD--VD-KRDKG------------------HRTPL----------
----------HLAC--ANGYESIVSLLIEKQCKINV--LDGEKRSPLIK-----------
-AIQYQKEKCVTILL-DHGADPNLVDFH----YN--TALHYAV-CGQSVSIVRKLLEHKA
NLEAKNKD-G---YTPLL------LAVVKNNAKMVK-FLLKKGAD--------VNAS---
-DNNQR-------TA-LMIALS--FEPT--NLVSL-------------------------
--LL-QQG-VDL--------SCQD------IYG-FTAAE---YA-SC---NGF---T---
------------------------------------------------------------
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-----------------------------

MVA-----EVSPKLAASPMKKPFGFRGK--------------------------------
------------------------------------------------------------
-------------------MGKW-CCCCFPCCRGSGKNNMGAWRDHDD---SAFTEPRYH
VRREDLGK-----LHR---------------AAWWGEV----------------------
PR---ADLIVMLRG-PG--IN-KRGKKK------------------RTAL----------
----------HLAC--ANGNSEVVRLLLDRQCQLHV--FDSKKRTALIK-----------
-AVQCQEDECALMLL-QHGTDPNLPDMY----GN--TALHYAV-YNEDKLMAKTLLLYGA
DIESKNKG-G---LTPLL------LAVHGQKQQMVK-FLIKKKAN--------LNAL---
-DRFGR-------TA-LILAVR--CGS-A-SIVSL-------------------------
--LL-QQN-IDV--------FSQD------VFG-QTAED---YA-VS---SHH---NI--
--ICQLLSDYKENQMPKNSSGN--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------SNPEQ-----------
---------DLKLTSEE------------------EPQ------------RLK-------
--------------------------------GSENS-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------QHE--------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------KVTQEPDINK-----------
---DCDREVE--------------------------------------------------
---------EEMQKHG--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----SNN------------------------------VGLS------------------
------------------------------------------------------------
-----------------------------------------E-------NL---------
--------------------------------------------------TDG-------
------------------------------------AAA---------------------
---G---------NG---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------D-GGLV---------------------------P----
----Q-------------------------------------------------GKSRKH
----------------------------------------ENQ-----------------
--QFPNTE------------------------------------------------IE--
------------------E-----------------------------------------
----------------------------------------------------YH------
-RPEKKSNEKN-------------------------------------------------
------------------------------------------------------------
-----------------------------K------------------------------
-------VKSQIHSV---------------------------------------------
------------------------------------------------------------
-------------------------------DNL---DD---ITWPSEIASEDY------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------DL
------------LF---SNYETFTLLIEQLK---MD--FND--SASLSKIQNA----VIS
DEHLLEL---KNSH-------------------YEQLTVEIEQMENV-------------
--VHVLQ----KELSEAK---ETQLQLAHQKGE-CEQEC--YSSR---------------
------------------------------------------------------------
------------YDILVLEKYFNSLF----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-----------------------------

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--MTS---------------RGGEKRGGSEGSPKPTVSAMRKTPSV--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------GSVRSQKDQL-
----------SLSYRGDRWSSDSSWL--SDSAGSDSE--------H-------------V
EGAL--------------------------------------------------DQP---
-----QHDVRLEDLCELHRA--------------ARSGD-------VP-----GVERVLA
PGD-----------------------------------PGVNKRD-RKESLRHLIPKCKM
EQSPESLPPNNNPDWHPTNLTVSDKTCQKSKILNVDDQCPSVSPSMPENQSATKELRQMN
LTEQEKM----------N---------------------VSGNDSLR--DLC-QSQLPE-
----------------------NKESK---------------E------AEQDLELTSEE
E---QERLKGHENKQPQ----KMSQETEMAKDSDRED------------------IPVYS
ILPHAQKSEEMWIEQDKLEWKNKLKL-----------VTNELKQRFGE------------
------IRETYKIP----------------------------------------------
----VCPEEEPLLDNSMRKTHVKDIPFNLTN-N-------------------------IP
GCVEEDASEVSVSVVFETFPEQNEPSLKSIIH---------PYSHPYSGSLEHACQSSSK
LHLHENKLDCDSDNKPGIEHIFSMDEN-FSNDAGIKKAR-NPEEVTVEMKE-----G---
QEF-DLQMTKNMNQNSDSC-----------------------------------------
---------------------------STNNYKSLKPKL-E--NL-SSLPPDSDRTSEVY
LHEELQ---QDMQKPETEVDRVEEMF-----LALKKENVQLQKEVEEEVEKH---SSNST
ELSG-----------NPAHGAAAG------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------NNDDGL-NQQ-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------FPRKK-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------KKGR-DRPADKTSNEKNK---VKNQVH-----------
---------------------------------------------------PEADF-ADS
VGPSETASEDCELS--HSTYENFLLLIEQLG---ME--CKD--SVSLSRIQDT----FCF
YEHLLKV---KNID-------------------YEQLTVKIKQTENT-------------
--VSVLQ----KELRETK---KTELQLELQKIE-LEKQL--YSLRLALKQEKEEKGNAVM
LY-NKYSEP----LRLKEEE------------------CGKEVETKQRLKWTLRRLVKEL
KTVRNNLD-LVVQERNDVQKQLSEEQNARILQDQIL-----TS---K--QKELE------
--IAQKKINSE-ISHRHKKEKD---LLHE------NCMLQEEIALLRLEIDTVNNQNQQK
EKKYFEDIEVVKEKNDNLQKIIKLNEEKLT--------ETILQYSGQLNDL-TA------
ENKILSSE-----------------------------------LENEKQNQ---------
--ERLEIEMESYRCRLAAALHDC--DQSQT-SRDPK----LDFQRTRQEWIHLQDKKKVD
MSDLQAKTEILS--------------------------E-KLSNAESKISS--LQIQLHN
TR-DAVERKSLI-LER--LQRDL--SQTHCEKKK-----IEQMYQT-EQRKL------K-
-----ESVEERLSQLQSENTLLPQQLDDAHKKA---NSQEKTISTIQD----QFHAFAKN
LQAES-EKKILSLQEKNKELMDEY-NHLQERMHQCEKEKAR RKV----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------DLIEAQETAPSRCLHLDAE-----------
-NEVLQLQQTLFSMKAIQKQCETLQKNKKQLKREVVNLKSY---MER-NMLECVEAEQH-
KLLIKEKAKKEI-AEKLNEAIL---TLQKQAAVSQEQLAQ-LRED-NTTSV KTQMELTIK
NLESEI-SRINTSSADF------NKTELERYK----ELYLEEVKVRESLS-NELNRTNEK
IAEVSAQLTVEKELTR---SPFA------ACSTRPILEPPCAGNLNDSEDLNRKHIPRKK
KSA---------PES-MESYLLKMQQKLQNDITTEVTAA-TKCEPEPYVAS-----P---
----------------------PESA-----------------YQKNLNQDPVLEATKEY
VQILSRK--YMI------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

-------------------MKIFGFGSKKG------------------------------
--------------------------------------------------------ESPL
GSSI----------------SPGRDS-----------------------GRRIHFQPGYR
IRDKDLGK-----IHK---------------AAIVGKI----------------------
AK---VQQILLLGK-NG--LN-DRDKM------------------NRTAL----------
----------HLAC--ANGHSAVVTLLLERKCLLNL--CDNENRTALMK-----------
-AIECQEEECATLLL-EHGADPNVMDVS----GN--TALHYAI-FCQNIPLTAKLLSCKA
NIEARNKD-D---LTPLS------LAVSERQQQMVE-FFAKKEAN--------IHAV---
-DKMKR-------NG-FQLAKY--KDTF-----------------------NLVDLYLIN
HCMS-FMC-TKH--------CSDV------------------------------------
------TE----YKHLNSLPLPI-------------------------------------
FKS---------------------------------------------------------
---------------------------------------------------FK-------
-------K-----------------------------------------------VLKKL
VNELFQSTNLIFRFSN--KPGV--------------D-------SWPTSDD---------
--------EDLDLKPSS-------------------GV--PLTVLSNT------------
--EGGVKK------------------KNE---------LE--------------------
---------------------N-------------------TDYVE--------------
------------------------------------------------------------
-----------------------------EGGPA--------------------------
----------------------------------Q----QDK---------KDPTTEM--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------EA-------------FKVTIQNE
NKE----EINMMSALGLGEEEDIESPWDSEKK-KKKKK----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------HK------
---------------------------SIEVEVS---DNVCDT-----------------
----VDESGLIQ---------QIKSGGNS----NQEFVAMEDE-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------GSDRLTLKQEGEQRRNADM
LY-EKIREQ----LRRKEDQ------------------YSKKVEMKQQLELTLRALDMEL
KTVRNDLN-QIFHI----------------------------------------------
--------------YYCEEAKD---LLRK------NHMLQDEIAMLRLEIDAVKNQYQEK
EKKYFEDIEIVKGKNDDLQKAIKRNEETLT--------KTVSQYI-KLNAL-T------A
KNTMLNSK-----------------------------------LENEK------------
---RLETKVESYRSRLAAASHDH--DQCQTSKRDME----LAFQRARDERLHLHDKMKSD
VANLKDNNEMLS--------------------------Q-QLSRVKSKFNN--LEIKLHH
TR-DSLREKILM-LEC--VQRDL--SQTERQKQE-----IEHMYQN-EQGKV------NK
YIA----LEERLSQLQSENMLLQEQLDDTQNRA---DSKEKTVISIQD----QFQPMVRE
LQAER-EKQGLVLEERNKELIKEC-SHLKKRMCQYENEKAEREVNIQKKKF---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

----------------------MFDG----------------------------------
--------------------------------------------------------YKPE
RWPI--------------LRE----R---LC-------------------SDGFSFPEYC
IKLSHLRR-----IHR---------------AVFHGRL----------------------
EK---LKY-LLLT-RSD--PN-KRDKK------------------ERTAL----------
----------HLAC--ATGQPGMVSLLVSARCELNL--YDREYRTPLIK-----------
-AVQLRQEACATILL-KNGADPNIMDFF----GR--SALHYAV-YNEDTSMIETLLAYGT
DIEGCSEH-E---CQPLL------LAVSRAKVNMVE-FLLKKNAN--------VNAV---
-NYLNR-------SA-LILAVT--LGEK--DIVIL-------------------------
--LLKQHN-IDV--------FSRD------VCG-KTAED---YA-IE---TQN---KV--
--IFGLVSEYKRGKTSEELPINS-----NPVSSQ----------------KQPALKATSE
KKDSVSNIATETKDGEISGTVSTPKKEGVGLVN---------------------------
-----------TVEEDEHD----WNGAICTQDEDFSSIL---------------------
--------------------------------SLGCLECLCRSLGRP------DNIAQP-
--------VTEDEFAL--KSAIISKLYILNRKIISLKSLEDV--LPPVEDCFDRSLYIPD
NVAQPVTKNEFDLEPEN------------------VS-AFSFT----SVSIVK-------
------I---LSYSFL-FSECWVLIDRH-GVFEDINVDLLNNEEK------------S--
------------------------------------------------------------
------------------------------------------------------------
-------------------------------LSA--------------------------
---------------------------T--------------GEKA--NVSPEQTPLF--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------THTVED
RDHISTRFLGSMDSLTSSEGSSERPPLSTLTP-E--------------------------
----------------------------------------EADPSSKVAIRRKDS-----
------------------------------------PPPGKVSSEKQPACKVT----SDQ
-NDSILNI-----------------------------ATEIKDGQKSGTVSSEK------
------QPALKATSEKNDSVSNIATEI---------------------------------
-----------EEGPTSGTVS--------SQKQKGREVYIQLKCHCN--CV------SSQ
LSGKL---KSMIFSVSSQKQPVLKVTSDEKD----------SVSNTATEIKDG-------
------QESAIVSSQKQPALKAT---SDKEDSVSNIATE-----------------IKDA
QISGTVSSQKQPVVK------------VTSDE---KDSVSNIA----------TEIKDGQ
QSGTVSSQKQPTLKATSDKEDSVSNIA------TKIKDAQISGTVSFPSNSQAPQLQATQ
GSGTHLRRQSVCSQMS-NSVL--GEPLLSSKLSDRYCLSR-------LPLARKGNSQTPC
TSWGTVNGTCSYLVILR---KRSIQQEQLT---------ILNIYA----------PNTRA
------PRFIKQVLRN--------LQRDLDSH----------------------------
-----------T-------MVMGDFNT-SL-STL-DQRDRKKKQE-----R---SKIDTL
ASQLKELEKQEQ------TPSKPSRRQEITKISSELKEIETQKTLINESRSWFFEEI---
-----------------NKLDRPLARLIKK-KKWAKTESIPFEN---------------W
HK---------------------------------------------------------T
RMPCLTTPVQHSVGSSGQG----------NQAG-------ERN-------------KG--
----------KNQYRETGLTAQELEKTTLKFIWN-QKRAHIAKTIPSQKKPKTIKTLEGK
LG------NTIQDIGMSK------------------------------------------
D----F-MTKAPKAMA-----------TKAEIDKWDLIKYYGTMK-NDEL----------
MSFVGTLSSQKPLAWKATSDRKDSLLNIAT-------E--I----------KDGQQSGTV
-----------------------------------SSQKQ--PALKATSDKEDSVSNIAT
------------------------EVKDGQQSGTGNFAKHIMS------------CSVKI
EKNFSSPNKSFSVSPQK---------Q-------SSWKVIFKKKVPVLNIATRIMAGRK-
-------------------------------SGTEYPENLPTLKATIEN-----------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------KD-SVL-NTATKMKGVQTSTPA
EQDLGMA------SQGKQKRLEDYEN-NQPRVKNQIH---------SRDD----------
-------------------------------------------------------L-DDI
IQSSQIASE-DD--SLCSNCKNVILLIDQHE---MK--CKD--CIHLSKIKNT----FCF
CKRSIKL---KDNH-------------------CERRIVKIQKMKNK-------------
--VSVLR----KRLSEKE---EIKSCLEHEKLE-CKQEL--CSVRFAILQEKEKRRNVEE
LH-QKVREK----LRTTEEQ------------------YRIEADVTE-VKLALKSLEMEL
KSVGKNS-----------------------------------------------------
---------NQ-ISDTDKKEED---LLHE------NHLMEDEIATLRLEIDTIKNQNL--
EKKYLKDFEIMKRKHEDLQETLKRNGETLA--------KTIADYSVQLTAL-T------D
ENATLRSK-----------------------------------LEKETQSR---------
--QRLETETESYHCRLNAALSDH--DQSHSLERDQE----LGFQGTVDKWCHLQENSNSC
-------VLTLS--------------------------Q-QLSKAESKFRV--LETELHY
TR-EALKEKSLV-FEH--VQREL--NQKQCQMKN-----IEKMYKN-EYDKM------EK
CIEKQ----ERFCQLQKQTMLIQQQLDDARNKA---DNQEKAILTIQA----RCDARVQN
FQAEC-RKHRLLLQEDTKRLVKEL-NHLKEKERQNEKEKAEREV--VVRQLQQKRNDV--
--LNKQ------SSTKALLDASSRHCVHLENEIQDSRKILDQIRSR-FPEIQDQLTATIR
C-----------------------------------TKEMEGHVHKLEVENAMIRKTIKK
QDDEIEQLE----KILQRS-----------------------------------------
------------------------------SLM-------------------QPVFR-K-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------MNKLFSFWKRKN------------------------------
--------------------------------------------------------ETR-
-------------------------------------------------------SQGYN
LLEKDLKK-----LHR---------------AASIGDL----------------------
KK---LKECLQIKK-YD--VN-MQDKK------------------YRTPL----------
----------HLAC--ANGHTDVVLFLIEQRCKINV--LDSENKSPLIK-----------
-AVQCQNEDCATILL-NCGADPDLRDIR----YN--TALHYAV-CGQSLSLVGKLLEYEA
DLEMKNKD-G---CTPLL------VAVTNNNPKMVK-FLLEKGAD--------VNAS---
-DNYQR-------TA-LMLAVS--GEPT--CSVNH-------------------------
--LL-RQG-VEL--------CCED------IVDSQLRNM---FI-SL---VLP---YT--
--HNSLRAMERRNMLN--RHLIL-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------G--------------
----------TT--CD--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-----------------------------

------------MGVGGW------------------------------------------
------------------------------------------------------------
--FLG-------------ACRRRVASWRENR----------------RQATDGFSNIQYR
IRQKHLGM-----IHK---------------AAIAGDV----------------------
KK---VDEILLLRL-NE--IN-DRDKK------------------KRTAL----------
----------HWAC--AHGHSGLVTHLVARKCQLNL--TDNENRTALIK-----------
-AVQYQKDVCASILL-ELGADPNITDMY----SN--TALHYAI-NNENISMAGKLLAYGA
DIEARSQG-E---LTSLL------LAINRKKERMVA-FLLKKKPD--------LTAV---
-DNFER-------SAL-ILAAR--NGS-------------------TN----------VV
YQLL-QHN-VDV--------VFQD------ISG-WTAED---YA-VA---YNF---R---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------DIRR--------------LI
SEYK--------------------------------------------------------
------------------------------------------------------------
-----ANK-------------------------------KH-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------K---S----LQNSNQ
EQDLKMTSKGEQENLQE-------------CENNQQQVA--------EKMKTHR------
---------------------------NKKMEVS---RNLDANYSDS-------------
-----DDDELIQ---------ERRSRKPD----NHQFPRQKSEEY---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------NRLAKKTSNKENK---VKRHLYFKD--------
------------------------------------------------------DL-DDI
IWSSETTSEDDELP--YSDDKNFMLLIEQHR---ME--CKD--FVSLLKIKNA----ISA
HERLIEH---KIYY-------------------CEQLTVKFQKMKNK-------------
--ISILQ----NELSETD---KTKSQLEHQKLE-WKQEL--HSLRLILQQEEEKRRN-PE
KY-GKDTEK----FKIMEEQ------------------YWTQAGLKKQLKLTLKSLEMEL
KTVRNNLN-QSS------------------------------------------------
--------------HTYEKQKD---LWQK------NHLMQDEIARLKLEKDTIKHQNEEN
ENTYFKDIEIIKKKNEDLQKTLKLNEETLT--------KTINWYSEELNVLTL------D
KNTVLSSE-----------------------------------LEKEKQRK---------
--QRLETEMELYSCRLAAALCDR--DQSQSSKRDLQ----LAFQNTVNQWCHLQENMNSH
I-------EILS--------------------------Q-QLSKAESKSSG--LETELHY
ER-EVLKEKTLA-IEH--MQGVI--SQTQCRVKA-----IEHMYQN-DQHIV------EK
YVRKQPSVEDGLFQIQSQNSLHQQQLNDAHKKA---DNQEKTIINIQA----KCEDTVEK
LEAEC-RKHCILLEENNKGLMEEY-TLLKERQCQYEKEKEEEEV--VVRKLKQELGDA--
--LNKQ------LLSESMLEISSQHQNTLEDEIQDTNKKLGQMRSQ-VCMKLSMSTVTL-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------MKKIFGFGSKKG------------------------------
--------------------------------------------------------ESPL
GSST----------------SPGREG-----------------------RNRSNSHPGYH
IRDKDLGK-----IHK---------------AASVGNV----------------------
AR---VQQILLLRK-NG--LN-DRDKM------------------NRTAL----------
----------HLAC--ANGHPAVVTLLVERKCQLNL--CDNENRTALIK-----------
-AVQCQEEECASILL-EHGADPNLADLS----GN--TALHYAA-FGQNISIAAKLLSYNA
DIEARNKD-D---LTPLL------LAVRENKQQMVD-FLAEKEAN--------THVV---
-DKIKS-------NR-QLISEY--KEEK--RPKSPSLNSNLVVDESSEE-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------DSLSRLSD--KPGV--------------D----D--SWPTS-D---------
--------EDFDFDTKP-------------------VLKPSLTTLMSASQLPK---KITE
AKCGIVGP------------------ENNTFFEDNNSASE--------------------
---------------------N-------------------EDVV---------------
------------------------------------------------------------
-----------------------------ETFPK--------------------------
----------------------------------PSINVQDFSNSA--FPSPESFLKPFK
SLT---------------------------------------------------------
------------------------------------------GL----------------
-----------------------------------GLTKEGETKPETGKKE---------
---NSTDVIE----SAPQE--------------PTTHDN-------------LTSVNGAR
RNN----RSDMLSALGLE-EDDIESPWDSESI-SESLPQKFVD---------------HF
SGASGQRGKNLLDG---E------VED---------------------------------
------------------------------------------SPEEYPHLKPA----VGV
-KESVPNK-----------------------------TLGMK------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------DLQK----------------
--------------------------------------------SRSDF-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------LA
EPDLEMTLEEEQERLDG-------------NENNHSQVE--------EEKKKHR------
---------------------------NSVMEVS---ENR---RDA--------------
-----AESGLIQ---------KRENGKTN----NQQFPTMENDV----------------
---------FDSSPGIYLKD-VKKNEN--EKWTSETLEITPVFEKADSP-----------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------TGGLLHMNDDSSLSE-
-------------------IDQDDG---RPAKKTSNEENK---VKEQINSVD--------
------------------------------------------------------DL-DDL
TQSSETASEGCELL--YSNYKNSMLLIEQLG---ME--CKD--SVSLLKIQDA----VLS
YERLLEL---KKSH-------------------CDVLNGKIKKMENK-------------
--VSGLQ----KELSETK---EVKSQLEHQKVE-WEQEL--CSLRFTLKQEEEKRRNADM
LY-EKIREQ----LRRKEEQ------------------YGKEVEMKQQLELTLRALDMEL
RTVKNNLN-QVIEERNDIQKQLSRKQNARILQDGIL-----TNHLSK--QKEIEMAN---
-KEMNSEVSE-----CREKEEN---LLRR------NHMLQDEIALLKLEIDTIKKQNQEK
ENKYFEDIEIVKEKNDDLQKTIKLNEETLA--------KTILQYSGQLNVL-T------A
ENTMLKSK-----------------------------------LESEKQNK---------
--DRLEAEVESYHSRLAAAIQDR--EQSQTSKRDLE----LAFQRAKDEWLRLQDKMNFD
VANLKDNNEMLS--------------------------Q-QLSKTESKFNS--LETELHH
TK-DALREKALV-LER--VQRDL--SQAQGQKKE-----IEHMYQS-EQGKV------NK
YMGKQESLEERLSQLQSENLLLRQQLDDAQNKV---DSKEKTVINIQG----QFQDIVKR
LQAES-ERQGLMLEERNKELTNEC-NHLKERLYQYENEKAER EA--VVRQLQQELADT--
--LKKQ------SMSEASLEVTSRYRANLEDEAQDLKKKLRQITSQ-LQEAQDRHTEAVK
C-----------------------------------TEKTQDHVQKLEIENAKLKVTVKK
QVGKIEQLQ----KNLLST-----------------------------------------
------------------------------GSSEDEKE-QLKKL---TELKQSLESS-LD
QEMKKNDELEKELTGFKEL-----LKMTR--------------RKLNE------YENG--
--EF-NSPGDLKTNQIEMDIQINLLKHKIDDLTAKLETASSKCLHLDTK-----------
-NQVL--QQELLSMKVMQKKCKKLEKNKSKLEQEVVNLKSH---IEM-NTVERSQVEQY-
KREIEERARQEL-VEKLKEVNL---FLQAQAA-SQENLEQ-LWEN-NYASI RSQMELRIK
DLESEL-SKMKSFQE------YSDKTELEKYK----QLYLEEVKLGKSLA-NKLNKTNER
LAEISAKLLVEKEQ---NRSLLH------TLTTRPVLEPPCARNLNNGLMFNRNLTPREN
LVI-STSSPRPSNDS-IETYLTKMQQELQKNISRELAEA-AAE-----FES-----G---
--------------------ICRTSPLGST-------------------DDLVLKTSQEY
VQILKKN--YML------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------MERLSAAAVKGE------------------------------
--------------------------------------------------------TDPE
RLSP-------------------------------------------FSQLVYTNNDSYV
IHHGDLRK-----IHK---------------AASRGQA----------------------
WK---LERM-MKKTTMDLN---IRDAK------------------KRTAL----------
----------HWAC--ANGHAEVVTLLVDRKCQLDV--LDGENRTPLMK-----------
-ALQCQREACANILI-DSGADPNIVDVY----GN--TAVHYAV-YSENLSVVAKLLSCGA
DIEMKNKA-G---HTPLL------LAIRKRSEQIVE-FLLTKNAN--------ANAV---
-DKFKC------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------I--H-------------------------QQLLEYKQ--------
-----------K------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--ITKNSQ-------------------------------------------NS-------
------------------------------------------------------------
-------------------------------------------------NP---EGTSEG
TPDEA-------------------------------------------------------
-------------APLAER-------------------------------------T-PD
MAE---------------------------------------------------------
------------------------------------------------------------
-------------------SLV--ERTPDE------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-----------------------------

------------------MKKIF---GKKG------------------------------
--------------------------------------------------------ESPL
ASFS----------------GRRRTGAGVGC----------------EHGNGVYSQPGYH
VRDRDLGK-----IHK---------------AASLGQV----------------------
AK---VQQILLLRK-NG--LN-DRDKM------------------SRTAL----------
----------HLAC--ANGHSEVVTLLVDRKCQLNM--CDSENRTALMK-----------
-AVQCQEEECATILL-EHGADPNLTDVH----GN--TALHYAV-YNENIPITAKLLLHNA
NIEAKNKA-E---LTPLL------LAINGEKQQMVE-FLVQKKGN--------INEV---
-DKLKS-------NY-QLISEY--KEEK--IPENLSEHSNSDNINC-----QITR---IF
FFFF-FET-ESR--------FVAQ------------------------------------
---ARVMP----WHQPSSQ-QPQ-------------------------------------
TPG---------------------------------------------------------
---------------------------------------------------LK-------
-------Q----------------------------------------------------
SFCLSLPSSWDYRLSD--KPGI--------------D----D--SWPTSDD---------
--------EDFDFDTKN-------------------VPKPSLTKLMTASQQSRK---NLE
AQYGTVKT------------------ESTILIEDRNS--P--------------------
---------------------R-------------------EDVV---------------
------------------------------------------------------------
-----------------------------EGLSA--------------------------
----------------------------------RPVKVQAFAHPA--FPSPGPRPNKPS
LTS---------------------------------------------------------
----------------------------------------LANL----------------
-----------------------------------GLTAEV-TKPAIGKKE---------
---NGIGIAS----PIV-E--------------QT--DD-------------NLTLDGVR
KNN----RNDMMSALGLGQEEDTESPWDSESI-SENLPQKYVD---------------NL
SGAADQKEDDTVNG---Q------VE----------------------------------
-----------------------------------------ESPKKFPHLKPT----IET
-KDCVLNK-----------------------------AVGIK------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------DK------------------
---------------------------------------------HTYG-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------SA
ERDLEVTSEEEQESLEG-------------RENNQPWVE--------EERKKHK------
---------------------------SQEMDVS---ENLYDGDD---------------
----DDDGGLIQ---------QRKSGKTD----NQQFSRKEKEKC---------------
---------DSSGPALHMKE-VRKNDN--EKWISE-SAMTPVFEKG--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------KKQIHSMD--------
------------------------------------------------------DL-DDL
TRSSETASEDCELP--YWNYKNTMLLIEQLG---MD--CKDFLYIFIPF--SS----LVQ
ISSYLE------------------------------------------------------
--------------------------TEENQIH-IRISI--FNCRFTLKQEEEKRRNADM
LY-EKNREQ----LRRKEEQ------------------YRKEVEAKQELELTLRTLDMEL
RTVRNNLD-QVVQERDDTQRQLSREQNARILQDGIL-----TNHLCK--QKEIEMAQ---
-KKMNSEVSH-----SHEKEED---LLHK------NHMLQDEIALLRLEIDTIKIQNQEK
EKKYFEDIEIVKEKNDDLQKTIKLNEETLT--------KTISQYSGQLSVL-T------A
ENTMLNSK-----------------------------------LENEKQTK---------
--ERLETEVESYRSRLAAAIHDC--DQSQTSKRDLE----LAFQRAREEWFRLQDKMNFD
VSNLKDNNEILS--------------------------Q-QLSKTESKFNS--LEIELHH
TR-DALREKTLV-LER--VQRDL--SQTQSQMKE-----IEQMYQN-EQGKV------NK
YIGKQESVEERLSQLQSENMLLRQQLDDAQNKA---DNKEKTVINIQD----QFHAIVKK
LETES-EKQSLMLQERNKELINEC-NHLKERQYQYENEKAEREV--VVRQLQQELADT--
--LKKQ------SMSEASLEVTSRYRLNLEDETQDLKKKLGQIRSQ-LEEARDQHAEAVR
C-----------------------------------AEKTQDHMQKLEKENCKLKVTIKK
QADKIERLQ----KNLLSA-----------------------------------------
------------------------------SSCEDEKE-DLKKL---TELKQSLEYN-LD
QEMKKNDELEKELSGLKNL-----LKMTR--------------KKLNE------YENG--
--QF-SVYGDLKTSQFETDIQINKLKHK--------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

MVV-----EVCSKPAASAMKKPFGLRSK--------------------------------
------------------------------------------------------------
-------------------MGKW-CFPCFPCCRGSGKSNVGTWEDYDD---SAFKEPRYQ
VHREDLGK-----LHR---------------AAWWGKV----------------------
SR---ADLIVMLRS-TD--VN-KRDKKK------------------RTAL----------
----------HLAS--ANGNSEIVKLLLGRRCALHA--FDSKKRTALIK-----------
-AVQCQEDECVLMLL-EHGTDPNLPDVY----GN--TALHYAV-YNEDKLLAKALLLYGA
DIEAKNKC-G---LTPLL------LGIHGQKQQMVK-FLIKKKAN--------LNAL---
-DKFGR-------TA-LILAVC--CGS-A-SIVSL-------------------------
--LL-EQD-IDV--------FFQD------LSG-KTATD---YA-VS---SHH---DI--
--ICQLLSDYKEKQMSKNSSEN--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------SNPGK-----------
---------EAEE-----------------------------------------------
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-----------------------------

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------------------------------------------------------------
------------------------------------------------------------
-----------------------------------QV--PDDST----------------
------------------------------------------------------------
----------------FSETSQEE---ERPAAKTASEKNK---VLIQMDVTD--------
------------------------------------------------------DL-D-L
THSSDTTSEDVKLP--TSTYKEAVLLLEQLT---VD--HT--GSAILLKIQNI----LLK
YEQIIEH---EKNR-------------------YAAVWREVRKLESE-------------
--KEESK----LKAEETQ---DLKSILAHQEVE-WKSDI--QSLKFTLKQEEEKRLRVET
LY-EKTKEK----LRRKEEQ------------------YCKEMEEKQQLELQSRNLEMEL
VTLRKLFK-QVEDERDETQRQLSQEKSARALQEGIL-----NNHLWR--QKELEEET---
-R-RTIGKSSD-ESDT-EREKD---LLYK------NQLLQDEIAMLRLDLDQIRLRHQEE
EGKYLEEIETLKEKNEDLQKELKLNEEALT--------QTVFQYNGQLNLL-KT------
ESTMLTSK-----------------------------------LEQTKESK---------
--DRLETEIESFRSRLNTTVQEL--ERHQSSRSDVE----RTFQRERDEWLRLQDKLHHD
FSDVREANKSLS--------------------------Q-QLSNAESKANG--LENELHQ
LR-QTLREKTLL-LEM--TQKEL--SQTQCQAKE-----YDHARQL-EKDQV------SK
LIIKQESMQERLAQLQSENLLLRQQLEDLQNKG---IIKEKVVNDVQD----RFNDIFNK
LRADT-EKQVYLVEERNKELNAKC-IDLREQVFKHETDKIEREG--MIRQLQQELADA--
--LKKQ------SMSEASLEVTTRYRSDLEEDKLHLQKELEKAKTK-LREVEEKYLQEAT
ASAQ-----------------KLQDQLLASSE--------------TNTTIKQLEEHVQQ
----REERS----KGKLS------------------------------------------
-----------------------------GYLCESERK-KVKKL---IELKRPVE-LRLD
QEMRRNLELQKDFKRLKRL-----LSRAT--------------KKIKV------YEEREM
ESQL-NLKGEMKSRYSEMVSEVDRLRTKVAELSQQLDMESKKSMQLEAQ-----------
-NRDL--REELS---TLHGNCEKLEKSKCQLKEEVAKLQHH---LET-NMVDHSQIEQY-
KREVDERAGQEI-RQKLQEVNL---FLQAQAA-SQDRLEH-IRAS-HHASLRNQLKDRIR
DLECEL-EKIKNTQQDKC-----VQAEVEKYK----ELYLEEMKTRRCLA-KKLERANER
LEEANAKLLRERHK---SKSLITSSIVSG------VLYSTALGHLGNNLGLSRSLSLGGS
FLT-PAENTLSSRNR-VAAFVAKVRQELDEKITKELKEA-TAE-----LET-----G---
--------------------CT------------------GSSKNLHVDQDPLCRAIEEY
RDVLTKN--YMI------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------------------------------------------------
------------------------------------------------------------
----------------------DIG------------------------VDGTSCSEGYH
LRDKDMGR-----IHR---------------AASIGNE----------------------
AK---VEELLLQKK-YE--ID-EPDKM------------------NRTPL----------
----------HLAC--ASGYPDVVSLLVERNCSLNV--CDSENRTPLIK-----------
-AVQCQQEECVGILL-SHGADPNVVDTT----SN--TALHYAA-LGDNTTIAVKLLEHHA
DIEAKNQT-G---YTPLI------LAVRKHNEAMVD-VLLKNGAD--------VNAC---
-DNSKR-------TA-LMIALSTSTKPT--NIINL-------------------------
--IL-EYD-VDL--------SCQD------DYG-WTTKD---YA-SV---SGV---HL--
--HRDLVLQ---HEKRKLDQPLS-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------A--------------
----------GI--SS--T-------------------------DGGSDTGF--------
-----------T------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--LSAHAL-------------------------------------------AK-------
------------------------------------------------------------
-------------------------------------------------EV--ME-----
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-----------------------------

------------------MKKIFDFGKKEQ------------------------------
---------------------------------------------------------VPP
CPPF--------------KLPNF------------------------FGLHTPNYIPGYV
IQSKDLPK-----IHK---------------AALLGDV----------------------
AK---VQHLLLFGK-NS--VN-DVDRE------------------KRTCL----------
----------HLAC--ANGHPDVVSLLIERKCDLNL--LDTDHRTPFMK-----------
-AIQCEEVECATLLL-EHGADPNLGDGS----N---NALHYVA-FFQNVDMASKLLQYKA
DIDAKNKE-G---LTPLF------FAIRAKKFDIAE-FLLKNGAN--------VNAL---
-DGYKR-------YS-DKSFK----------IQKYF------------------------
------------------------------------------------------------
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-----------------------------

------------------MRKLFSFGRRLG------------------------------
--------------------------------------------------------QTVL
GS----------------------------------------------IERDEYAGPGYH
IRDAELRK-----IHR---------------AAIKGNA----------------------
AE---VERCLRCRS-QD--VD-ARDKK------------------GRTPL----------
----------HLAC--AYGHVAVVTLLVSRKCQIDI--DDGLNRTPLMK-----------
-AVHGQKEACSIILL-EHGANPNIQDVY----GN--TALHYAI-YNSVTSLAEKLLSHQA
NIEAINKE-G---NMPLL------LAIICKRQQMVT-FLVKNQAN--------VHAV---
-DNFRR-------YS-SSF-----------------------------------------
--FF-FLN-KNV--------FSQD------VFG-QTAED---YA-VC---CDL---IR--
--IQQQILEHKNRKFKNHLQDDN-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------R--------------
----------E----T--A-------------------------AT--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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-------K-------------------------------------------PL-------
------------------------------------------------------------
-------------------------------------------------NY--S------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------K
------------------------------------------------------------
----------------------------SF-------ILTKHMDF---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------SVEHDLKVASEETKERFKR--SENIQPQDF---------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------QSHGKKKD---VMYE------NCMLKRDTAVLRQKLYTIKNASLRK
EKEHILEIKSTREINANFQKSVRLNEEMIT--------KTISQYCQQLNEF-K------A
KNTRLNSE-----------------------------------LEKVKHNK---------
--DRVEAEIAFLRSILAAAVNGH--NERVKT-KYLQ----VALQRAQDVSV--REIMTSN
ISQLKDKNELLT--------------------------E-QLSNAQMKFHM--LKEKLHE
TR-DALREKTSA-LES--AERDL--RQKRHRIKE-----MEQMRLN-EEAKE------SQ
FIGKQNCVEERIHQVECENLLLEQL-LEAACKE---GNNENIIINTQG----GWD-----
---EC-VKEGLLLEEKNKELINEY-NYLKEKLFQYEKEEAE IKV--IVRQLQEELAGS--
--LKNV------SVPESPLEGTSHCHINLDE-TRASKKKLFQVGSQ-PKEK-EELR----
------------------------------------------------------------
-------------K----------------------------------------------
-------------------------------------------L---FELISSLEYN-VD
QIRKKNNELEEETTGYKKL-----LKMTI--------------SMLNV------FGNE--
--DF-RFHGDLETDQLKMDILIKKIKQKLDDLIAEKEAVSSKCINLDKE-----------
-NQVI--QQELLSMKKVQEKCEKLEEDKKMLEEGILNLKTH---MEK-NMIEVGKVQEY-
KLELEERAMQAI-EKLEEI------HLQKQVD-YEKQLEQ-LKKE-NTASQ-NEMELKTK
DVECKL-SKIKTAYEE-----V--TTEFEEYK----EAFAIALKANDSMS-KKYMKSKKK
MAVFSTKLFMEKER---MKSCLR------TLPTRPDPESPYVENLNSIG-CNRKYIPETP
VRI-PTSGPGTSNNC--KNDLTE-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------YC
IRDKDLRK-----IHK---------------AAIVGNV----------------------
AK---VQHVLLFG-KNG--PN-DRDKT------------------NRTAL----------
----------HLAC--ANGHSAVVTLLLERKCQLNL--CDNENRTALMK-----------
-AVECQEEECVTLLL-EHGADPNVMDVC----GN--TALHYAV-FCQNLSLAAKLLSCDA
NIEAKNKD-N---LTPLL------LAIIERRAQMVE-FLVKNGAN--------IHAV---
-DKLKR-------TA-LMLAVN--YGST--NVVGL-------------------------
--LL-QQG-VDI--------FSQD------VFG-QTAED---YA-II---SGF---NI--
--YLGREIFSHFKRRK-KKKRNS----SCSQLTID-------------------------
LYSQAAPAGPGSPVFMV--MHTSTS-ESQLLCSHMYACS---------------------
-----------------------------------------------SSHCCKAPALA--
--------------------------------------------AGP------PSFSPT-
--------LRSLTWSP--RVSL---DLHDEHSIRQLISAYKE--ERPKT----------P
PENSNPE--KVGWRKYE-----------------------IW-----SRIKSL-------
------SPSREVCGLF-VWSCWSKRKKDVK----------WTSRS------------F--
------------------------------------------------------------
------------------------------------------------------------
-------------------------------TLR--------------------------
------------------------------------------G-SV--RVRKLRLRFQEN
K-------------RSKGVALH--------------------------------------
------------------------------------------------------------
------------------------------------LEKSGRT------------LDSAG
-----HN-------------------------------------------------RIKD
EGR---KVGLREVSLELKRKLDRTPKWLQSIY----------------------------
---------------------------------------PEKRWQGVLEVGE-TT-----
------------------------------------APLSNS-----QASKPA----VLV
-KDSVPSK-----------------------------TVGMKDLQTSSS--VPL---I--
KEEAQEKPDGDE------------------------------------------------
--------------------N--------NHSQSSSKLCFTENKIDV--EN------DQ-
LDIEH---VFIKIEESFYNDT---------------------------------------
--------------ENKNGADPV---VTFEDK----SME-----------------LD--
--LE--------------------------------------------------------
-NGNSSPKSHRASKVYVNEEFQKD------------------------------------
----------------------------------M-------------------------
------------------------------------------------------------
--------------------------------------------------------Q---
-R---------F-------KNEIDM--------------LQVELL-----ALEKENSTFK
RVSFDIGS--------------IKPQQK-------RKNIVFISKGE----KANAEANNKI
--------------ENKDLYNKEVAI------ILSVKLSLKVQ--EKK---H---KSSEV
EV---------------------------------------------------------S
DNECDAAAES--------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------GLIQQRKSGR-NSS-----------
-QEFPAAENEDFDSSYPGVHRKEDN-----------------------------------
------------------------------------EE----SPWKLKVSLTHTVCSISG
CQMHEETAEWLNGCLLMNSFTKNKSLLKK---------ITYQ------------------
---------------CR---------V---------YL--K-------KKSLGL---RE-
-------------------------------KHHMTRRRYS-EKKKMNF-----------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------KK-YYP-SKNLSLRVEMTLRL-
-----------------------------PRLCVSES---------SQSS----------
-------------------------------------------------------L-PSS
MWSLFALWLDKSTCDVSFPHSLPS-NPVRWQ---LE--HAD--SVSLLKIQDT----ILS
RERLVGF---QRSH-------------------CELLRE-FYRMKSK-------------
--VRGLQ----KELSETK---EVKSQLEHQKVE-WEREL--GSLRFTLKQKEENRRNADM
LC-EKMREH----LRRKEDE------------------YSKEVEVKQQLELTFRAVEVKL
KAERNNL-----------------------------------------------------
---------NQ-VSDSCEKAKD---LLCK------NHMLQEEIAMLRLERDALKNQHREK
EENYFEDIEILKVKNDDLQKTIKLDEEMLT--------KTISHYTGQLNAL-T------A
ENAMLNSK-----------------------------------LEKEKESK---------
--QRLETEVESYRSRLAAALHDH--DQSQTSKRDLE----LAFGRARDEWLCLQDKMKSD
VANLKDNNEMLS--------------------------Q-QLSTVESKFNK--LKIKLHH
TR-DDLREKTLM-LEH--VQRDL--NQAEGQKQE-----IEHVYRN-QQGRV------NT
YLGKQESLEERLFQLQSENMLLRQQLDNARNRA---DSREKTVISIQD----QFQQIVRE
LQAKR-EKQGLMLEERNKELVKEC-NHLKERMCQYENEKAEGEV--S-------------
------------------------------------------------------------
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-----------------------------

------------------MKKLFTFWRR--------------------------------
--------------------------------------------------------KDQP
-------------------HNPSSHL-----PV----------GRV--S-THHPTQPGYN
LRDKDLKK-----LHK---------------AVSVGDL----------------------
EK---VKEYLQLKK-HD--VN-IRDRK------------------YRTPL----------
----------HLAC--ANGYSNIVSLLIEKNCKINV--CDSEKRSPLTK-----------
-AVQCAKEDCAAVLL-SHGADPNLADLD----GN--TALHYAV-CGQSISLVEKLLEHKA
NLEDQNKD-G---YTPLL------LAITENNAKMVD-YLLKRGAD--------VNAS---
-DKNQR-------TA-LMIAIS--DEPT--NLVSL-------------------------
--LL-QQE-VDL--------SCQD------IYG-FTAEE---YA-SF---NGF---TV--
--YHQLIANYGRKKNV--EQKSN-------------------------------------
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-----------------------------

-------------------MKLFGFGSRRG------------------------------
--------------------------------------------------------QTAE
GS----------------------------------------------ID-HVYTGSGYR
IRDSELQK-----IHR---------------AAVKGDA----------------------
AE---VERCLARRS-GD--LD-ARDKQ------------------HRTAL----------
----------HLAC--ASGHVQVVTLLVNRKCQIDI--CDKENRTPLIQ-----------
-AVHCQEEACAVILL-KHGANPNLKDIY----GN--TALHYAV-YSESTSLAEKLLSHGA
HIEALDKD-S---NTPLL------FAIICKKEKMVE-FLLKKKAS--------THAV---
-DRLRR-------SA-LMLAVY--YDSP--GIVSI-------------------------
--LL-KQN-IDV--------FAQD------MCG-RDAED---YA-IS---HHL---TK--
--IQQQILEHKQKILKKEKSDVG-------------------------------------
------------------------------------------------------------
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---------------------------------------------S--------------
----------SD--ES--A-------------------------VSIFHEL---------
------------------------------------------------------------
--------------------------------------------R---------------
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-------V----------------------------------------------------
------------DSLPASD-----------------------------------------
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----------------------------------------------------------DK
-DLSVATK--------------------------------------------Q-------
------------------------------------------------------------
-------------------------------------------------CV--PEKVSEP
LPGPS-------------------------------------------------------
-------------HEKGNR-------------------------------------IVNG
QGE---------------------------------------------------------
------------------------------------------------------------
-------------------GPPAKHPSLKPT-T---------------------------
---------------------------------------------------GVEDPAVKG
------------------------------------------------------------
----------------------------AV-------QRKNVQTL---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------RAEQALPVASEEEQERHER--SEKKQPQVKKGNNTNKSEKIQL--SEN---
------------------------------------------------------------
------------ICDST-------------------------------------------
--------------------------------------------SS--------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------AAAGR-LTQQRKIGKTYPQQFPKK-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------L-----------------------------------------------------
-------------------------------------KE--EHDKCTLKQENEEKTNVNM
LY-KKNREE----LERKEKQ------------------YKKEVEAKQ-LEPTVQSLEMKS
KTARNTP-----------------------------------------------------
---------NR-DFHNHEETK---GLMDE------NCILKADIAILRQEICTMKNDNLEK
ENKYLKDIKIVKETNAALEKYIKLNEEMIT--------ETAFRYQQELNDL-K------A
ENTRLNAE-----------------------------------LLKEKESK---------
--KRLEADIESYQSRLAAAIGKH--SESVKTERNVK----LALERTQDVSV--QVEMSSA
ISKVKDENEFLT--------------------------E-QLSETQIKFNA--LKDKFRK
TR-DSLRKKSLA-LET--VQNDL--RKTQQQTQE-----MKEMYQN-AEAKV------NN
STGKWNCVEERICHLQRENAWLVQQ-LDDVHQK---EDHKEIVTNIQR----GFI-----
---ES-GKKDLVLEEKSKKLMNEC-DHLKESLFQYEREKAEGVV--SIKEDKYFQ-TS--
--RKKI------------------------------------------------------
------------------------------------------------------------
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-----------------------------

------------------------------------------------------------
------------------------------------------------------------
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----------------------------------------------RTAL----------
----------HLAC--ANGHPEVVTLLVERKCQLNL--CDSENRTALMK-----------
-AIQCQQEECATILL-EHGADPDVTDVG----GN--TALHYAA-RGENLSIAAKLLSHNA
NIEARNKD-D---LTPLL------LAVSENKQQMVE-FLVKQEAN--------IHAV---
-DKMKR-------TA-LMLAVN--YEST--NIVRL-------------------------
--LL-QQG-IDV--------FSQD------IYG-WTAEE---YA-LV-------------
----------------------S-------------------------------------
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---------------------------------------------G--------------
----------FA--M---------------------------------------------
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-------------------LTLSDETCQRSKNLKVDDKCPSVSPSMPENQSATKELGQMN
LTEREKM----------DTG-VVL---------------LSGNDTLH--DLC-QSQLPE-
----------------------NKESK---------------E------AEQDSELTSEE
E---QERLKGCENKQPQ----KTSQEPEMAKDCDRED------------------IPIYP
VLPHVQKSEEMWIEQGKLEWKNQLKL-----------IINELKQRFGE------------
------IYEKYKIP----------------------------------------------
----ACPEEEPLLDNSTRGTDVKDIPFNLTN-N-------------------------IP
GCEEEDASEISVSVVFETFPEQKEPSLKNIIH---------PCYHPYPGSQEHVCQSSSK
LHLHENKLDC-------IGHIFSTDKN-FHNDASTKKAR-NPEVVTVEMK------D---
QEF-DLQMTKNMNQNSDSG-----------------------------------------
---------------------------STNNYKSLKPKL-E--NL-SSLPPDSDRTSEVY
LHEELQ---QDMQKFKNEVNTLEEEF-----LALKKENVQLHKEVEEEMEKH---RSNST
ELSG-----------TLTDGTTVG------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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---------------------------------------NDDDGL-NQQ-----------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------IPRKE-------------------
------------------------------------------------------------
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----------------------NGEH-DRPADKTSNEKNE---VKNQIY-----------
---------------------------------------------------PEADF-ADS
MEPSEIASEDCELS--HSVYENFMLLIEQLR---ME--CKD--SASLPRIQDT----FCL
CEHLLKL---KNNH-------------------CDQLTVKLKQMENM-------------
--ASVLQ----NELSETK---KTKLQLELQKIE-WEKEL--YDLRYDVL-----KRNAVM
LY-NKDSEQ----LRIKEEE------------------CGKVVETKQQLKWNLRRLVKEL
RTVRNNLD-LVVQERNGAQKQLSEEQDARILQDQIL-----TS---K--QKELE------
--MARKKMNSE-ISHRHQKEKD---LFHE------NCMLQEEIALLRLEIDTIKNQNKQK
EKEYFEDIEVVKEKNDNLQKSIKQNEETLT--------ETILQYSGQLNNL-TA------
ENKILNSE-----------------------------------LENGKQNQ---------
--ERLEIEMESYRCRLAAAVR--DCDQSQT-ARDLK----LDFQRTRQEWVRLHDKMKVD
MSGLQAKNEILS--------------------------E-KLSNAESKINS--LQIQLHN
TR-DALGRESLI-LER--VQRDL--SQTQCQKKE-----TEQMYQI-AQSKL------KK
YIAKQESVEERLSQLHSENMLLRQQLDDAHKKA---NSQEKTSSTIQD----QFHSAAKN
LQAES-EKQILSLQEKNKELMDEY-NHLKERMDQCEKEKAG RKI----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------DLTEAQETVPSRCLHLDAE-----------
-NEVLQLQQTLFSMKAIQKQCETLQKNKKQLKQEVVNLESY---MER-NMLESGEAEWH-
KLLIEERARKEI-EEKLNEAIL---TLQKQAAVSHEQLVQ-LRED-NTTSI KTQMELRIK
DLESEI-SRIKTSQADF------NKTELERYK----ELYLEEVKVRESLS-NELSRTNEM
IAEVSTQLTVEKE----SRSLFT------AYAARPVLESPCVGNLNDSEGLNRKHIPRKK
RSA---------LKD-MESYLLKMQQKLQNDLTAEVAGS-SQTGLHRIPQC-----S---
--------------------SFSSSSLHLLLCSICQPFFLILQLLLNMNLDPI-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------MKKLLTFWRR--------------------------------
--------------------------------------------------------KDEP
-------------------QGPSSHL-----PV----------AQA--S-THHPAQPGYN
LRDKDLKK-----LHK---------------AASVGDL----------------------
EK---VKEYLQLKK-RD--VN-VRDRQ------------------YRTPL----------
----------HLAC--ANGYSNIVSLLIEKQCEINV--CDGEKRSPLTK-----------
-AVQCAKEDCATILL-EHGAYPNLVDFD----GN--TALHYAV-CGHSVSLVEKLLEHKA
NLEYQNKD-G---YTPLL------LAVTENNAEMVE-YLLKKGAD--------VNAS---
-DKNQR-------TA-LMIALS--DEPT--NLVSL-------------------------
--LL-QQE-VNL--------SSQD------IYG-FTAED---YA-SF---NGF---TV--
--YYQLIANYGKGKKV--KQVSN-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------S--------------
----------KD--TI--L-----------------------------DTTF--------
-----------D------------------------------------------------
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--TEELK-----------------------------------------------------
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-------------------------------------------------ED--M------
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--------------WSSYHA--DLR--KIHRAAVKGDAAEVERCLARRSGNLNARDKQ--
-----------------HRCSPGWEGVPRP--------------------VKKSSC----
--SFSLC--IF-----------------------ALK-HF---QGLCMDSSTKPEDKVLT
VATKQCVPEKVSEPLPGTSDDKGSSVVNGKKAG---------------------------
-------------------------------------------QGFLV-------DSEEE
QERLERS---EKKE------------------------PEVKEGRNTNKSEEIQLSEHIC
DSTSSDA---ADGLTQQRKIRKTYPQQF-------PKDVKEKHDRCTLKQENEEKSNVNM
LY-KKLKEA----LERKWEQ------------------YKEEVKAK-QLELTVQSLEMEL
KTLRNTQN----------------------------------------------------
----------H-DFHNHEEMKD---LMHE------NGILKRDIAMLREKICTLKNDSLEK
ENKYFKDFEIFKETSAGLEKRYKLSEEMLI--------KTVSQCRQQLNDL-QG------
EITRFNSE-----------------------------------LGKEKENE---------
--ERLEAEIESYQSRLAAAIREH--NQMVTTERDLK----LSLQRTQDV--SVQINMSSE
---LKDENEFLK--------------------------E-QLSKTQIKFNT--LKDEFCK
TI-DALREMTLA-LET--AQNYL--SQTQQQLKE-----MKEMHQN-AVAKV------NK
STGKQNHVEERIYELQHESLWHKQQLDDAHQIA----DNRKIVINIQG----DF------
--IES-GKEGLLLEEKNKTLMKKC-NHLEERLFQHEKEKAEGEV--SIKEDKY-FQTS--
--GKNM------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------MERLSAAPVKGQ------------------------------
--------------------------------------------------------TGPE
RPSP-------------------------------------------FSQLVYTNNDSYV
IHHGDLRK-----IHK---------------AASRGQA----------------------
WK---LERM-MKKTTMDLN---IRDAK------------------KRTAL----------
----------YWAC--ANGHAEVVTLLVDRKCQLDV--LDGENRTILMK-----------
-ALQCQREACANILI-DSGADPNIVDVY----GN--TAVHYAV-NSENLSVVAKLLSCGA
DIEVKNKA-G---HTPLL------LAIRKRSEEIVE-FLLTKNAN--------ANAV---
-DKFKC------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------V--H-------------------------QQLLEYKQ--------
-----------K------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--ISKNSQ-------------------------------------------NS-------
------------------------------------------------------------
-------------------------------------------------NP---EGTSEG
TPDEA-------------------------------------------------------
-------------APLAER-------------------------------------T-PD
TAE---------------------------------------------------------
------------------------------------------------------------
-------------------SLV--ERTPDE------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-----------------------------

------------------------------------------------------------
------------------------------------------------------------
-------------------RD----R---LC-------------------SDGFLYPHYP
IKPYHLKG-----IHR---------------AVFCRDL----------------------
EE---LKF-VLLT-RYD--IN-KRDKK------------------ERTAL----------
----------HLAC--ATGQPEMVRLLVSRRCELNL--CDREDRTPLIK-----------
-AVQLRQEACATLLL-QNGADPNIMDFF----GR--TALHYAV-YNEDTSMIEKLLSYGT
NIEECSKC-E---YQPLL------LAVSRRKVKMVE-FLLKKKAN--------VNAI---
-DYLGR-------SA-LILAVT--LGEK--DIVIL-------------------------
--LL-QHN-IDV--------FSRD------VYG-NLAED---YA-SE---AEN---RV--
--IFELIYEYERKR-YEDLPINS-----NPVSPQ----------------K---------
------------------------------------------------------------
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--------------------------------QSAQKVIFKKKVSLL--NF------ATR
VMDGW---KS--GTVSSQKQPASKATSDKTD----------SALNIATEIKDG-------
------LQCGTVSSQKQPALKAT---TDEEDSVSNIATE-----------------IKDG
EKSGTVSSRKKPA-----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------L-------KATSDEKD-SF-SNI-TREKKDGEIS-----R---TVSSQK
PPGLKATS---------------DEKDSVLNIARGKKDGDKTRRVSSRKKPALKATS---
-----------------DKEDS-IPNIATETKDEQISGT---------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------VSSQKKPA-----------LKATSDEKDSFSNITREK-KD------------
GEISRTVSSQKQPALKATSDKKDSVSNIPT-------A--I----------KDGQQSGTV
-----------------------------------SSQKQ--PAWKATSVKKDSVSNIAT
------------------------EIKDGQIPGTVSSQRQPALKATGDEK----DSVSNI
AREIKDGEK---------------------------------------------------
-------------------------------SGTEYPENLPTMKATIEN-----------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------KD-SVL-NTATKMKDVQTSTP-
-------------------------------VKNQIH---------SRDD----------
-------------------------------------------------------L-DDI
IQSSQTVSEDGD--LLCCNCKNVILLIDQHE---MK--CKD--CVHLLKIKNT----FCL
WKRSIKL---KDNH-------------------CEQLRVKIRKMKNK-------------
--ASVLQ----KRLSEKE---EIKSQLEHERLE-LEKEL--CSLRFAIQQEKKKRRSVEE
LY-QKVREK----LRITEEQ------------------YRIEADVTKPIKPALKSAEVEL
KTEGNNS-----------------------------------------------------
---------NQ-VSETDEK-ED---LLHE------NRLMQDEIARLRLEKDTIKNQNL--
EKKYLKDFEIVKRKCEDLQKALKRNEETLA--------KTIACYSGQLAAL-T------D
ENTTLRSK-----------------------------------LEKQRESR---------
--QRLETEMQSYRCRLNAALCDH--DPSHTSERDQE----LAFQGTVDKCCHLQENLNSQ
-------VLILS--------------------------L-QLSKAESKSRV--LKTELHY
TG-EALKEKALV-FEH--VQSEL--KQKQSQMKD-----IEKMYKS-GYNTM------EK
CIEKQ----ERFCQLKKQNMLLQQQLDDARNKA---DAQEKAILNIQA----RCDARVQN
LQAEC-RKHRLLLEEDNKMLVNEL-NHLKEKECQYEKEKAEREV--AVRQLQQKRDDV--
--LNKR------SATKALLDASSRHCIYLENGMQDSRKKLDQMRSQ-FQEIQDQLTATIR
C-----------------------------------IKEMEGDAQKLEVENVMMRKIIKK
QDEQIERFE----KILQHS-----------------------------------------
------------------------------SLM-------------------LQVFE-S-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------MKKIFNFGRKKGQSPPRP------------------------
--------------------------------------------------------FIK-
------------------LPS-------YFG------------------VQTPYPTEGYQ
IRSKDLGK-----IHK---------------AALLGDV----------------------
AK---VQQLLLLG-KST--VN-DLDKM------------------KRTPL----------
----------HLAC--ANGYPDVVSLLVERKCELNL--LDNDSRTPLIK-----------
-AIECQQEECATILL-EHGADPNLGDSK----NN--NALHYIA-SGRTKFMAEKLIKHKI
DIEAKNKE-G---FTPLL------LAITTMNTEMAD-FLLKNGAN--------VNAL---
-DSCKR-------TA-LMIAVS--VESI--ALVTL-------------------------
--LL-QNN-ADY--------TLQD------IAG-WTAQT---YA-ER---YGY-------
------------------------------------------------------------
-----------------------------------P-------LH------I--------
--------YHKQIEK-QKELY--------------------N--------TCS-------
----------SQIS------------------CSEKASSTGFALGAPSLDKKE-------
-ES--SAEESISRLSD--N--------------PGPD---D---HLPSTDK-----EL--
-----------DFDTEV-------------------L--------IPSH--PV-------
------S------QQHNGY---SQSAEIHSVFLDS-----NSDLC----------DCS--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------LGALTIIF-
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-----------------------------

MPEDIDY-------DAQTPN--A------S------------------------------
---------------------------------------------------------EQP
HWYW--------------RL--WTCCLGYGC--------------LD--YQ-VDEYPAYL
IPYEPVGQ-----FQR---------------AASMGDL----------------------
ST---VEHFITSG-RYH--VD-KCDRR------------------NRTSL----------
----------HYAC--AHNHPEVVTLLIESNCNINV--QDDEGCTPLIK-----------
-ATERNNLECVSILL-KHGADPHMADFT----GN--TALHYAV-YNGNKAIASELLEYKV
DINTTTKH-G---FTPFS------LAVFEKKEKMAE-FL---------------------
------------------------------------------------------------
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-----------------------------

MVA-----EVYSMPAASSEKKPFGLRSKMGKWC---------------------------
----------YHCFPCCRGSGRSNVG----------------------------------
---TSGDHDDSAMKTLRSEMGKW-CCHCFPCCRGSGKSNVGAWGDYDD---SAFMEPRYH
VCGEDLDK-----LHR---------------AAWWGKV----------------------
PR---KDLIVMLRD-TD--VN-KKDKQK------------------RTAL----------
----------HLAS--ANGNSEVVKLLLDRRCQLNV--LDNKKRTALTK-----------
-AVQCQEDECALMLL-EHGTDPNIPDEY----GN--TTLHYAI-YNEDKLMAKALLLYGA
DIESKNKH-G---LTPLL------LGVHEQKQQVVK-FLIKKKAN--------LNAL---
-DRYGR-------TA-LILAVC--CGS-A-SIVSL-------------------------
--LL-EQN-IDV--------SSQD------RSG-QTARE---YA-VS---SHH---TV--
--ICQLLSDYKEKQMLKISSEN--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------SNP-------------
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-----------------------------

------------------MQWLSPVGGND-----LP------------------------
--------------------------------------------------------TGQE
RPSP--------------FSQL-----------------------------VYTNNDSYI
IQYGELRK-----IHK---------------AASRGQV----------------------
ST---LQKMTLKKKTIN--LN-VKDAR------------------KRTAL----------
----------HWAC--VNGHAEVVTFLVDRKCQLDV--LDGENRTPLMK-----------
-ALQCQSEDCANILV-DSGANLNIVDVY----GN--TALHYAV-YNKDLSVVAKLLSHSA
VVETQNKA-S---LTPLL------LAITKRSEQIVE-LLLTKNAN--------ANAV---
-NRFKC-------I----------------------------------------------
------------------------------------------------------------
---HQQLLEYIRKL-----SKNA-----GPAGTS------------------------AG
TPEEGAPLAERTPDTAESLVEKSPD-E---------------------------------
------------------------------------------------------------
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-----------------------------

------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------GYR
IRDKDLKK-----LHK---------------ATSVGDL----------------------
GK---VKEYLRLK-KHD--VN-VRDKE------------------HRHLL----------
----------HLGC--ASGYDV--SLLIEK-CKING---DSENRSPLDK-----------
-XXXXXXXXXXXXXX-XXXXXXXXXXXX----XX--XXXXXXX-XXXXXXXXXXXXXXXX
XXXXXXXD-G---CTPLL------LAVTKSNTEMVE-FLLKRGAD--------VNAS---
-DKNQ-------------------------------------------------------
------------------------------------------------------------
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-----------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------MK-----------
-AIECQQEECATILL-EHGADPNLRDKD----NN--TILHYVA-CGRTKFMAEILVKYKV
DIEAKNKE-G---LTPLL------LSITSMNTELAD-FLLKNGAN--------VNVL---
-DSYKR-------TP-LMIAVS--MESL--GLVTL-------------------------
--LL-QNN-ADY--------TLRD------ESG-WTAYT---YA-EQ---YGY-------
------------------------------------------------------------
-----------------------------------P-------LH------I--------
--------YHKQIEK-QEEYIEQQKKQF----------EKEK--------LCP-------
----------PQIS------------------CSEKPSDTEFALGASSLDKKG-------
-RI--DKPK---------------------------------------------------
------------------------------------------------------------
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-----------------------------

------------------MKKIFGFRN-KG------------------------------
--------------------------------------------------------PSPL
GSSA----------------RPRSNCVGFGR----------------ENA-SGSHVPRYH
IHDKDMGK-----IHK---------------AASVGDV----------------------
AK---VQHILILGK-SG--VN-DRDKK------------------DRTAL----------
----------HLAC--AYGHPEVVTLLVERKCEIDA--CDSENSTALIK-----------
-AVQCQEEECAAILL-DHGADTNVTDSS----GN--TALHYAV-YCESTSIAAKLLARGA
NIEAKNKD-D---LTPML------LAVKENKQHIVE-FLVKKKTS--------IHAA---
-DQLGS-------N--RQIFEY--DGKR---PK-NSENSNAVDNVSED------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------GSLTRSSH--IPDP--------------A----D--SWPTSDE---------
--------DDYNFDTKN-------------------VPKINLTELWTAAQQSKKN----Q
TKCGFEEP------------------DSRALFDDSNSASE--------------------
---------------------N-------------------EDAT---------------
------------------------------------------------------------
-----------------------------GIEPE--------------------------
----------------------------------SPARVQTL-SPS--CQSPDP------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------VEGAADPAIEGEE---------
---NGKDIIE----SASQE--------------Q-SHDS-------------LVRADGWH
RSN----KSEMMSALGLGEDEDEDSPWDSESL-SESVSLDGVA---------------PL
SGTEDHTGKRRARG---Q------IED----------------------------VTYIP
SCMSGSRSFKMAKLEESRTV--------------GIPVAHMEAPRRCPIMKPA----VER
-RAPVLNKSE---------------------------TVGMK------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------DVQT----------------
--------------------------------------------F---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------KP
EP--E-----EQTRLRG-------------SEDSQQKV---------EERRKYR------
---------------------------NNEAEPS---GNLYAGAADCA------------
------A-DGNP-----------PRGNTD----DLQFPRKGSEGH-----------G---
-----------SGPTLLMKE-AEKTEN--EKWVSKESVMMAVTESAGLP-----------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------TGGSLQMQDGSHLSD-
-------------------SDQSES---RPAKKTSNKNNK---DSKQTAAVD--------
------------------------------------------------------NL-DNL
TESSEMSSEDHELQ--GPDYERILCEIEHLR---LE--CKD--TVSLLKIRDA----VYS
YKRLIEL---KRSH-------------------CELLTGKLKRVESK-------------
--CKGLQ----KEVSETE---EVRSRLEHEKLA-WEQEL--CSLRFALKQEEEKRRSADQ
LS-ERMVEQ----LRRKGEQ------------------YQGEVEARQQLEVSLRSLEMEL
KTVRSHLN-QVLEERNETQRQLSREQNARMLQDGIL-----ANHLCK--QKEIEMEQ---
-KKMTSEASL-----SHEKEKD---LLHK------NQRLQDEVAMLKLEMDTIKNHNLEK
ERKYLEDIKIANEKNDNLQRMIKLNEETFT--------KTIFQYSGQLNNL-K------T
ENAMLSSR-----------------------------------LDNEKQSK---------
--ERLETDVESFRSRLASALHEH--AEIQTAKRDLE----TAFQRAKDEWFRLKDKMNFD
MSNLRDNNEVLS--------------------------Q-QLSKTERKLNS--LETEFHH
TQ-GELREKTLA-LKC--VQRDL--SQTQSQMKE-----VEHMFQD-EQGKV------NK
YMGKQESIEERLAQLQSENTLLRQQLDDAANKA---ESKDRTIVSIQD----QFQEMLNR
VQAES-QKHSLRLEDRNQELIIEC-SHLKERMCQYENEKAER EV--AVRQLQQELADT--
--LKKQ------SMSEASLEVSSRYRSSLEEEARDLKKNLSQLRSQ-LQEAQDQHREAVQ
R-----------------------------------AEKMQDHLQKLELENSKFKITIKT
QSEEIEQLQ----ENLSNG-----------------------------------------
------------------------------NLSEEDQE-KLKKL---TELKESLEYT-LD
QEQKRSDALEKELTEFKEV-----LKMTK--------------KELSE------YENR--
--EL-HLHQDMKSSQLEMDVPVNALVKKIDDLTEKLETASSKCLHLGKR-----------
-NQLL--QQELLLMKTLQKKCGKLEKSKRKLEQEVASLRSH---IEE-NMVEHSRVQQY-
AREVEDRARQDL-VEKLKQVNL---FLQAQAA-SQENLEQ-LREN-SNASL RSQMELRIQ
DLESQL-YKMKA-QE------DFDKIELEKYK----QLYQEEFRVRKALS-SKLNRTTER
LEETSTKLLLEEQQ---NRSLLS------SLSTRPVVECPCVGKLHNSLVLNRTLIPRES
LAV-PTSGLQPSNKR-VEIFLTKMHQELEKSINRELKEA-TAE-----LES-----E---
--------------------FCRVSPLGSA---------TKP------GQDLLSEASQEY
IDILKKK--YMIC-----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------MKRLLAAARKG-----V-------------------------
--------------------------------------------------------PDPE
RPSA--------------LSKL-----------------------------VYAKNDSYI
VHFGDLGK-----IHK---------------AASLGQV----------------------
RK---LESMTVTKKTID--LN-KRDVK------------------KRTAL----------
----------HWAC--VNGHVEVVTFLVDRKCQLDI--LDGESRTPLMK-----------
-ALQCQREACANILI-DSGADLNVVDIY----GN--TALHYAV-YSENLSMVAKLLSHGA
VIEVQNKA-S---LTPFL------LAIMKRSERIVE-FLLTKNAN--------ANAV---
-NEFKR-------TA-LMLAIC--DGSS--EIVGM-------------------------
--LL-QQN-VDI--------FAED------ICG-MTAEH---YA-AT---CGV---NL--
--IHQQLLKHKQKLSK-N-PQNT-----NPEGTP------------------------AG
TTDEAAPLAERTLDMAESLVERPPD-EAAPLAERTLDM----------------------
-----------------------------------------------------AESLV--
--------------------------------------------ERP------PDEAAP-
--------LVEGT-SD--K--I---QCQGKAT-SGKFEQSSE--ETPRK--------IMR
PTKETSE--KSEWPAKE-------------------------------------------
-----------------------RH-RKIT----------REEKE------------T--
------------------------------------------------------------
------------------------------------------------------------
-------------------------------SVK--------------------------
---------------------------T--------------ECVA--EVTPNKTEDLEK
G-------------TSKMIACP--------------------------------------
------------------------------------------------------------
-----------------------------------TKETSIKASTNGFLFHCESHQDEFN
-----ETL----MCD------TFKL-----SKSKG-------------------------
-------------------------------------K----------------------
----------RVEICV-----------------------VSV-SHTNINTHTQIS-----
------------------------------------DPPASP-----SQVAGI----KDY
-QTSVNNK-----------------------------SLNRNNLHYFNANPAQK---F--
PSQ-SKQKDDEEDRLDFENFLENVLQN---------------------------------
------------------------------------DECLPKATHQK--EF---------
---SK---ISGKLEDQNNRSGNLGTLCSVLG----------GILRQVTGYK---------
------------------------------------------------------------
------------------------------------------------------------
-----------------QE-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------RSF-----KKE---PPEK
PSAFKPA---------------TKMQNSVPNEAFEWKNEQTLRPAQ----KFPSESKQK-
---------------------DDEED------YLN------------F---E---NFLEN
LL---------------------------------------------------------Q
NDVYLPKATHR-------------------------------------------------
----------KEFDTISGKL----------------------------------------
------------------------------------------------------------
-------EESPHKDGL-----------LKPTCGMKVSIPNKALEL-KDR-----------
-ETFKAGRPGKSYSFKVSIFVEKNIPN-------KKYTLKNKR-----TVREDELDSGKV
K---------------K-----------------KEQKKN--LFWEGEIISV--------
------SDTQNYVCLTEATYQKEIKTIKGKIEVKTSFDQMFV------------------
---------------SK---------H-------EDWYALT-------TKAQHILTFEI-
-------------------------------LSAKSPEKSSDFEPATEM-----------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------QN-SVP-NKGLEWKNKQTLRA-
-----------------------------DNMFTLKS---------GQEA----------
-------------------------------------------------------Y-AES
HWSSKSVSESAAQNYTCLPEATYREETKRIN---GK--LKD--STSLSKSLDA----VPS
CERAQEL---KKDH-------------------CEQLTTKLKKMKNK-------------
--FCVLQ----KELSEAK---EIKSQLENQKVK-WEQEL--CSVSNQLNQLEERVSAIED
QM-NEM KISYPAKLSFISEG------------------EIKSFTDRQILRDFVTTRPALQ
ETLKEAL-----------------------------------------------------
---------NM-VSHPCENGND---LFHE------NCMLKKEIAMLKLEIDTLKHQHQEK
ENKYFEDLKILQEKNADLQMTLKLKEKTLT--------KRASQYSGQPKVL-I------A
ENAMLTSK-----------------------------------LK-EKQDK---------
--EIREREIESYHPRLASALQDH--DQSATSRKKQE----LAFHSAGDTHL--QGKMNVD
VRNTIYNNEMLH--------------------------Q-PLCEAQRKSKS--LKINLNY
AG-DALRENTLV-SEH--AQRER--DETQYQMKK-----AEHMYQN-KQDNV------DK
HTKQQQSREQTLFQLQSKNMWLRQQLIHAHKKA---DNKSKITININF----CE------
----K-KMQHHLLKE-KNEEFNYG-NHLKECTDQCEKEKAETEV--S-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TAL----------
----------HLAC--ASGHPEVVTLLAERKCQLDL--CDGQNKTALIK-----------
-AVQCQDEECASILL-EHGADPDVADGN----GN--TALHYAV-CNSNIPIAEKLLSHNA
NIEARNKV-K--------------------------------------------------
------------------------------------------------------------
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-----------------------------

------------------MKKIF------K------------------------------
---------------------------------------------------------GHS
PW----------------------GFLSFRH------------------A-ENQEPPRYL
TGYMPVKR-----IHK---------------AASVGDI----------------------
PQ---VQKMLEFG-DID--VN-VTDRK------------------KRTAL----------
----------HYAC--AHGQSEMVSLLLWYDCNIEA--RDREESTALIK-----------
-ATQRQHEICVKILL-ENGADSNAVDIH----QN--TSLHYTV-YNKDTTIAAKLLAFNA
DTEIKTKN-G---YTPLI------LAVLENKQEMVE-LLLQAAAN--------INAL---
-DNCKR-------SA-LIHAVR--TQSK--NMISL-------------------------
--LL-QQG-ANA--------SLVD------IYG-ATAQS---YA-VF---ETF---Q--V
LSQ---------------------------------------------------------
GPGPR-PELTTKESRHS-FD----------TKDGLVSCSPRFKEDNKRMEENTDAVDK--
------------------------------------------------------------
--------------------------------------LGSFAHRPSNSEPIEVEDEPSL
--------------ST--KPPV-------------------V--QSPVLTES--NLWA--
-----------GYP--A------------------DWPEPIKFSRQPAVYNPT-------
-------------EW--REDMESRSV----PLES------K-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------QQGAA---LPGKE-------------------------------------
------------------------------------------------------------
-----------------------------------TKV----QTQ---QQPQTRAFKEPG
ANDPDLPSRE-NAKDELV----------SL------------------------LAPLEE
KKPQMK----EFP----------------------------------------------V
TEAAKFQTDVKL---EREGVL-------EFEEKGLEICQDSN------------------
------------------------------------------------------------
--------LEA---------------------------------AESTESYSILRFTK--
PD------VSDPE-----------------------------------------------
----------------P-------------------------------------TARKDE
YKLDTKDEGRLERQP---LAHQHQA-----------------------------------
------KQTSPPPVQLQER--SQ--GPEMGTA------------------------SDEE
DTSGLSKSAKGQMLGGKLTLRENPE---------------------GKETVQCVINKPTQ
KG--DEIYED---------------VSAN-------------------------------
---VYLKEERPP-DVS-GKTHLTSDPTTLAY-NMFDCGDR--------------------
--DV---SAALVSVALQTSPRQEEGGLGNAFPSPSSSLDVDYSGQPLTKF-PLV----R-
-----NKLDCENNASK--------LEESFHKRKEKSS-----------------------
------------------------------------------------------------
----------KNIESRKVKGKCPEV-R------MGEKQEGHEFKSQSQKT----------
--------------------------MKPKRTNWQLDIRHMLKSSDAN------------
--------R-LSNAKERSHVSEVK-------------------SWGD-SALASDM----Y
RKSKGTQDLFLKPLPCKGN----------FEAPART---------------LG---TARD
APPGGPTTRAFADEELRG----RL-SDSEFRILE-------------EEILAWEKVHLEN
ESVSENL-LNKCEGIISD---------ATD----------QQGRYLD----------M-E
Q----A-TEVD--AE-------------GTSQLEQ---KNLDSSE-NTQS----------
---SNP-DLSKTC------------PQAQSAPADPT-------TPIQALSEEE----SK-
------------------------QTY------PPSL--------QLKKMSEDLEIN---
-------TKDDKECAPG----------HPEVPSVKAHGRESLTGDMRGQNRESKQSCPEL
--QHTAAEGLESICPVEDPFPGGCR---------SHFKVE---EVSRKQQRMDLEVSELS
PADEKDEPAR-SVPDSCIKD-SKDSEK--EAWSPREPVVTPEFEKSPPAG----------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------A---------D-LL------LLKDGHLLTK-
---------------------MDRVE-GRLTKREAKEKHK---TKSQVNE----------
-------------------------------------------------------M-EEA
SHGSE----------------------PRAP---AP--GWG--SDSPLKLWNT----THS
DERLIEL---KNSH-------------------CELLTRKPGKMGNM-------------
-----------REQTKVK---KVKTWSQHKEVA-WD-KL--CTLRFPLKQDEKQEN-AEL
TF-QQKKPQ----LQREKEQ------------------CGGSVEWTQ-H-SEIRTVIEEL
KALEKDLR-QFHN-----------------------------------------------
---------------LKESWET---TYYK------YLHMVVKLQFIEQELIGIKTEQKKC
RHLL-KN----------Q-KNLEEEVLHLK--------SWMRESEIQAR-----------
----DQNN-----------------------------------IENLRDTN--D----AA
MISQMDLRIKNMESQLARRGAQR--Q----------------------------------
---------------------LLEEGCLDVSTA-M----------QKRVAWPSP------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
-----------------------------

------------------MKKFFCFRTGKVCSSPTF------------------------
--------------------------------------------------------DIQ-
------------------LMN-------DLR-------------ALVYKQEVTETQPRYN
IRVKELKK-----IHK---------------VALLGNI----------------------
WN---MEQLL-LR-GKN--VN-KRDKR------------------KRTPL----------
----------HVAC--TIGHADMVDFLVERKCKLDL--YDGDYRTPLMK-----------
-VCGS---SCVCLRW-I-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-----------------------------

------------MEVRGSFLA---------------------------------------
------------------------------------------------------------
------------------ACRRRMATWRKNR----------------D--KDGFSNPGYR
VRQKDLGM-----IHK---------------AAIAGDV----------------------
NK---VMESILLRL-ND--LN-DRDKK------------------NRTAL----------
----------HLAC--AHGRPGVVADLVARKCQLNL--TDSENRTALIK-----------
-AVQCQEEVCASILL-EHGANPNVRDMY----GN--TALHYAI-DNENISMARKLLAYGA
DIEARSQD-G---HTSLL------LAVNRKKEQMVA-FLLKKKPD--------LTAI---
-DNFGR-------TAL-ILAAR--NGS-------------------TS----------VV
YQLL-QHN-IDV--------FCQD------ISG-WTAED---YA-VA---SKF---Q---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------AIRG--------------II
SEYK--------------------------------------------------------
------------------------------------------------------------
-----ANK-------------------------------RR-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
---------------------------------------------E---S----LQNSDS
EQDLEMTSEGEQERLEG-------------CESSQPQVE--------EKMKKCR------
---------------------------NKKMEVS---RNVHADDSDNY------------
---NDDVDELIH---------KIKNRKPD----NHQSPGKENGEF---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------DRLARKTSNEKSK---VKSQIYFRD--------
------------------------------------------------------DL-NDI
TGSSEKTSEDDELP--YSDDENFMLLIEQSG---ME--CKD--FVSLSKSKNA----TAA
CGRSIED---QKCY-------------------CEQLKVKFQKMKNN-------------
--ISVLQ----KVLSETD---KTKSQSEHQNLQ-GKKKL--CNLRFILQQQEEERIKAEE
LY-EKDIEE----LKIMEEQ------------------YRTQTEVKKQSKLTLKSLEVEL
KTVRSNSN-QNS------------------------------------------------
--------------HTHERERD---LWQE------NYLMRDEIARLRLEIDTIKHQNQET
ENKYFKDIEIIKENNEDLEKTLKRNEETLT--------KTITRYSKELNVL-M------D
ENTMLNSE-----------------------------------LQKEKQSM---------
--SRLETEMESYHCRLAAALCDH--DQRQSSKRDLQ----LAFQSTVNEWCHLQEDTNSH
I-------QILS--------------------------Q-QLSKAESTSSG--LETELHY
ER-EALKEKTLH-IEH--MQGVL--SRTQRRLED-----IEHMYQN-DQPIL------EK
YVRKQQSVEDGLFQLQSQNLLYQQQCNDARKKA---DNQEKTIINIQV----KCEDTVEK
LQAEC-RK----LEENNKGLMKEC-TLLKERQCQYEKEKEEREV--VRRQLQREVDDA--
--LNKQ------LLLETMLEISSERRINLEDEARSLKKKLGQMRSQ-VCMKLSMSTVTL-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------MRKLFSFGRRLG------------------------------
--------------------------------------------------------QALL
SS----------------------------------------------GD-KEYAGPGYH
IRDWELRK-----IHR---------------AAIKGDA----------------------
AE---VERCL-RRF-RD--VD-ARDRK------------------DRTVL----------
----------HLAC--AHGRVEVVTLLLSRSCQIDI--CDRLNRTPLMK-----------
-AVHCQEEACAIILL-EHGANPNIKDIY----GN--TALHYAV-YNKGTSLAEKLLSHHA
NIEALNEE-G---NTPLL------FAINSRRQQMVE-FLLKNQAN--------IHAV---
-DNFRR-------TA-LMLAVQ--HSSS--SIVSL-------------------------
--LL-QQN-INI--------FSQD------MFG-QTAED---YA-VC---CDL---RS--
--IQQQIL---E------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------H--------------
------------------------------------------------------------
-------------K-----------------------------NK-------I-------
-----------------------------LK----------NHLR---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------N----------------------------------------------------
------------DNQETAA-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------VK-------------------------------------------PA-------
------------------------------------------------------------
-------------------------------------------------NL--K------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------K
------------------------------------------------------------
----------------------------RK-------EGAKGKTL---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------ESEHNLKVASEEKQERLER--SGNKQPQDS---------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------QSYGRKKD---VMYG------NYMLKRDIAMLKQELYTIKNDSLRK
EKEYIQEIKSITEMNANFEKSVRLNDEMIT--------KTTAQYSQQLNVL-K------A
ENTRLNSK-----------------------------------LEKEKHSK---------
--ERLEVEVESLHSSLATAINEY--NEILER-KDLE----LVLWRADDVSV--HEKMDSN
ISQLTDKNELLT--------------------------K-QLSKARVKFNT--LKGKLHE
TR-DALREKTLA-LES--VQMDL--KQAQYRLKE-----MKQMHPN-EEAKE------SQ
SFGKQNSLEERIHQ-ELENLLLEQQ-LKDAYKE---GNNKEIVINIQE----DCL-----
---EN-GKEDLT-EEKNMELMNEY-NYLKEKLFQYEKEEAEGEV--IVRRLQEELADH--
--LNKF------SMSESPLEGTSHCHINLDD-TRASKKKLFQVGSQ-PEEKHEEFR----
------------------------------------------------------------
-------------K----------------------------------------------
-------------------------------------------L---FELISSLDYN-VD
QIRKKNHKLEEETTGCKKC-----LEMTI--------------NMLNV------FGNE--
--DF-SCHGDLNTDQLKMDILFKKLKQKFDDLTAEKEAVSSKCVNLAKD-----------
-NQVL--QQEFLSMRKIQEKCEKLEEDKKMLEEEVLTLKTH---MEN-NMVELGKVQEY-
KSELDERTMQII-EKLEET------HLQEQAK-YEKQLEQ-LNKD-NTASL-NKKELTLT
DVECKF-SEMKTAYEE-----V--TTELAEYK----EAFAVALKQ---------------
--WIQTKLLMEKER---MKYSQH------VFLIRQDPRLLVLKSVLVIW-A--------P
FLF---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TAL----------
----------HLAS--ASGRQEVVTLLAERKCELDI--RDGRGKTALIM-----------
-AVQCQEEKCANILL-EHGADPKAAEVS----GN--TALHYAA-HHGMISIAEKLLSLSV
NVDQIKLL----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-----------------------------

------------------MKRLSAAAVKGE------------------------------
--------------------------------------------------------TGPE
RPSP-------------------------------------------FSQLVYTNNDSYV
IHHGDLRK-----IHK---------------AASQGQA----------------------
WK---LERM-MKKTTMDLN---IRDAK------------------KRTAL----------
----------HWAC--ANGHAEVVTLLVDRKCQLDV--LDGENRTPLMK-----------
-ALQCQREACANILI-DSGADPNIVDVY----GN--TAVHYAV-YSENLSVVVKLLSCGA
DIEVKNKA-G---HTPLL------LAIRKRSEQIVE-FLLTKNAN--------ANAV---
-DKFKC------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------I--H-------------------------QQLLEYKQ--------
-----------K------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--ISKNSQ-------------------------------------------NS-------
------------------------------------------------------------
-------------------------------------------------NP---EGTSEG
TPEEA-------------------------------------------------------
-------------ASLAER-------------------------------------I-PD
KAK---------------------------------------------------------
------------------------------------------------------------
-------------------CSV--ERTPDE------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-----------------------------

MVA-----EVSPKLAASPMKKPFGLRGK--------------------------------
------------------------------------------------------------
-------------------MGKW-CCCCFPCCRGSGKNNVGAWGDHDN---SPFTEPRYH
IRREDLGK-----LHR---------------AAWWGKV----------------------
PR---ADLIVMLRG-PG--IN-KRDKKK------------------RTAL----------
----------HLAC--ANGNSEVVRLLLDRQCQLHV--FDSKKRTALIK-----------
-AVQCQEDECVLMLL-QHGTDPNHPDTY----GN--TALHYAV-YNEDKLMAKTLLLYSA
DIESKNKG-G---LTPLL------LAVHGQKQRMVK-FLIKKKAN--------LNVL---
-DRFGR-------TA-LILAVR--CGS-A-SILSL-------------------------
--LL-QQD-IDV--------FSQD------VFG-QTAED---YA-VS---SHH---NI--
--ICQLLSDYKENHMPKNSSGN--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------SNPEQ-----------
---------DLKLTSEE------------------EPQ------------RLK-------
--------------------------------GSENS-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------QHE--------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------RLLLPFDCLC-----------
---PAPR-----------------------------------------------------
---------------G--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----G------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------S---------
--------------------------------------------------YKG-------
------------------------------------RQA---------------------
---S---------LS---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------C-GGLH---------------------------P----
----V-------------------------------------------------RVSRLK
----------------------------------------CTG-----------------
--LYIQK-----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------LLIYFISPLF---SP--DAD--SASLSKIQDA----VIS
DEHLLEL---KNSH-------------------YEQLTVEIEQMENT-------------
--VHVLQ----KELPEAK---ETQLQLAHQKGE-WEQER--YSLR---------------
------------------------------------------------------------
------------YDILVLEKYFNSLF----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-----------------------------

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-------------------------------------------SVSVLKIWDA----LHS
YKTSVDL---KKDH-------------------DELLIGKTKKLENK-------------
--VRTL-----KELTETR---EVKSQLEHEKLH-QEGEL--GNLRFALQQEEEKRRNVDQ
FY-EKIKEQ----LRKKEEQ------------------YYQEVEAKQQLEISLRTLDIEL
KTVRNKLN-QVLEEQNDTLSQLSPEQNCRMLPDGIL-----ANRFCE--QKEIE------
--MAPEKMSPE-VSISHE--ED---MLHK------NHRLQDEITRLRLEIDAIKNQNQVK
EKKYLGDIEIANEKNDDLQRTIKLNEE------------TIFQSNGQLNSL-TI------
ENTMLNSK-----------------------------------LENEKRIK---------
--ERLETEIESYRSRLAAAVHNY--DESQTSKRDVE----LAFQRARDEWVRLQDKLNFD
ISNLKDNNEMLS--------------------------Q-QLSKAERKFNS--LEIELHH
TR-DALREKTSV-LEQ--VQRDL--KQTQCQMKE-----IKHMYQD-EQGKV------NK
YMGKQESIEERLSQLQSENALLRQQLDDAHNKV---DYKERTLINIQD----QFHDIVKT
LQGES-KKQSLMLEDRNKELINEC-NHLKERVYQYENEKAEK EV--VVRQLEQELADT--
--LKKQ------SMSEASLEISSHYRINLEDETRDLKKKLSQIRSQ-LEEEQNRHTEAAQ
CAEK-----------------------------------MQEYLQKLELENSRLKVKIKK
QAGKTEQLQ----KNLLSANLSE-------------------------------------
--------------------------------D---KE-QLKKL---SELTESLEFT-LH
QEKKKNGELQKELTGFKK-----LFKMTK--------------TKLNE------QENGD-
---F-YFHGDLKSSE--LDIPINMLIHKVDDLAAKLETASSKCLHLDKN-----------
-D-LL--QQELLSMKNIQKKCETLEKKEKKLEEEVVNLRSH---MEK-NVLEHGQAEQY-
KQEIEERARRDL-VEKLKQVNL---FLQTQAA-SQENLQQ-LRET-NNASM RSQMELRIK
DLESEV-SKMKT-QEES------NKIQLEKYR----QCYLEEFNTRKSLS-SKLNKANER
LEEANTKLLVEQQQ---NRSLLS------TVSTRPVLECPCVGNLNHSLVFQRSFLPREN
LVV-PPLNLQPSNTSIIESYLTKMRQELEKSITREVREA-TVE-----LES-----G---
--------------------SFKVSP----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--RSPRTV-----LHL---------------ACARGRV----------------------
EV---LRYCTTF-------PE-NPSRS------------------PRTVL----------
----------HLAC--AHGRVEVVTLLLHRRCQIDI--CDRLNRTPLMK-----------
-AVHGQEEACAIILL-KCGANPNIKDIY----GN--TALHYAM-YNEGTSLAERLLSHHA
NIEALNKE-G---NTPLL------FAINSRRQHMVE-FLLKNQAN--------IHAV---
-DNFKR-------CT-LILAVQ--HNLS--SIVTL-------------------------
--LL-QQN-IHI--------SSQD------MFG-QTAED---YA-FC---SDL---RS--
--IRQQILEHKNKMLKNHLRNDN-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------Q--------------
----------E----A--C-------------------------RGLFVNFF-----F--
-----------PSG-----------------------------DV-------V-------
-----------------------------SLYHQS--GVQWRDLR---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------S----------------------------------------------------
------------LQPSPPR-----------------------------------------
------------------------------------------------------------
----------------------------------------------------------FK
-QFSCLSL-------------------------------------------LR-------
------------------------------------------------------------
-------------------------------------------------SW--DNRHMRP
RPGN--------------------------------------------------------
-------------F----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------FFK
------------------------------------------------------------
----------------------------SF-------ILTKHMDL---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------SAEHNLKVASEEKQERLER--SENKQPQDS---------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------QSYGKKKD---AMYG------NFMLKRDIAMLKEELYAIKNDSLRK
EKKYIQEIKSITEINANFEKSVRLNEEMIT--------KKVARYSQQLNDL-K------A
ENARLNSE-----------------------------------LEKEKHNK---------
--ERLEAEVESLHSSLATAINQY--KEIVER-KDLE----LVLWRADDVSR--HEKMDSN
ISQLTDKNELLT--------------------------E-QVHKARVKFNT--LKGKLRE
TR-DALREKTLA-LGS--VQLDL--KQAQHRIKE-----MKQMHPN-GEAKE------SQ
SIGKQNSLEERIRQQELENLLLERQ-LEDARKE---GNNKEIVINIHR----DCL-----
---EN-GKEDLL-EERNKELMNEY-NYLKEKLLQYEKEKAEREV--IVREFQEELVDH--
--LKKF------SISESPLEGTSQCHINLDE-TWTSKKKLFQVEIQ-PEEKHEEFR----
------------------------------------------------------------
-------------K----------------------------------------------
-------------------------------------------L---FELISLLNYT-AD
QIRKKNRELEEEAIGYKKC-----LEMTI--------------NMLNA------FANE--
--DF-GCHGDLNTDQLKMDILFKKLKQKHCLAD---------------------------
-------------------------------------------------------LQLY-
TR--------------PGF------HLER-------------------------------
-V----------------------------------------------------------
-PA--------------LSALLG------AP-----------------------------
--------------------------------PLSASPG-PPL-----VEREEIGEHLWE
ALILALGPGGDSDEDLGAPQFHSASPL-------------DTPRTTRTTPSWPCHQAH-S
GSV-ITK--MQVQRQPPYLVPASDPPWWHNMEEARVACSQLPCSPRWHLGLGKSFSKGKL
ETLMSLEGRVNVASEQPWQPAASSHPTCLNATTVLQMEPHRGNEQQAQEQAMRCLWGSSP
CMRAPTALWASWVPRGRPQAILRRTPCSSAERAQSEWESKIDE-------DGPQGTQLNF
SANELTCKQIMVMGFKKE--DPIQELDPVMDLLVLSQGHQVNIPDIIHIHKEALTKVMES
RQHVAEGKTEVQRLMTSESQEQDFFGHCG

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------RTPL----------
----------HLAC--ANGHTDVVLFLIEQQCKINV--QDSENKSPLIK-----------
-AVQCQNEDCATILL-NCGADPDLRDIR----YN--TALHYAV-CGQSLSLVEKLLEYEA
DIEAKNKD-G---YTPLL------VAVINNDPKMVK-FLLEKGAD--------VNAS---
-DNYQR-------TA-LILAVS--GEPA--CLVKL-------------------------
--LL-QQG-VEL--------YYEG------IVDSQPRNM---FI-SM---VLP---YR--
--YPQFTASYGKKKHA--K-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-----------------------------

----------------------MGVRG---------------------------------
---------------------------------------------------------SFL
A-----------------ACGRR--------MA----------TWRKNRDKDGFSNSGYR
VRQKDLGM-----IHK---------------AAIAGDV----------------------
NK---LLESILLGL-ND--VN-DRDKK------------------NRTAL----------
----------HLAC--AHGRPGVVADLVARKCRLNL--TDSENRTALIK-----------
-AVQCQEAVCASILL-EHGADPNVRDMY----GN--TALHYAI-DNENISMAGKLLAYGA
DIEARSQG-G---HTSLL------LAVNRKKEEMVA-FLLKKKPD--------LTAI---
-DNFGR-------TA-LILAAR--NGST--SVV---------------------------
Y-QL-LQ--------HNIDVFCQD------ISG-WTAED---YA-AA---SKF---QA--
--TRLRNDIRGRARKA--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
-----------------------------

-------------------MKLFGFGSRRG------------------------------
--------------------------------------------------------QTAQ
GS----------------------------------------------ID-HVYTGSGYR
IRDSELQK-----IHR---------------AAVKGDA----------------------
AE---VERCLARRS-GD--LD-ALDKQ------------------HRTAL----------
----------HLAC--ASGHVQVVTLLVNRKCQIDV--CDKENRTPLIQ-----------
-AVHCQEEACAVILL-EHGANPNLKDIY----GN--TALHYAV-YSESTSLAEKLLSHGA
HIEALDKD-N---NTPLL------FAIICKKEKMVE-FLLKRKAS--------SHAV---
-DRLRR-------SA-LMLAVY--YDSP--GIVNI-------------------------
--LL-KQN-IDV--------FAQD------MCG-RDAED---YA-IS---HHL---TK--
--IQQQILEHKKKILKKEKSDVG-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------S--------------
----------SD--ES--A-------------------------VSIFHEL---------
------------------------------------------------------------
--------------------------------------------R---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------V----------------------------------------------------
------------DSLPASD-----------------------------------------
------------------------------------------------------------
----------------------------------------------------------DK
-DLNVATK--------------------------------------------Q-------
------------------------------------------------------------
-------------------------------------------------CV--PEKVSEP
LPGSS-------------------------------------------------------
-------------HEKGNR-------------------------------------IVNG
QGE---------------------------------------------------------
------------------------------------------------------------
-------------------GPPAKHPSLKPS-T---------------------------
---------------------------------------------------EVEDPAVKG
------------------------------------------------------------
----------------------------AV-------QRKNVQTL---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------RAEQALPVASEEEQERHER--SEKKQPQVKEGNNTNKSEKIQL--SEN---
------------------------------------------------------------
------------ICDST-------------------------------------------
--------------------------------------------SS--------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------AAAGR-LTQQRKIGKTYPQQFPKK-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------L-----------------------------------------------------
-------------------------------------KE--EHDRCTLKQENEEKTNVNM
LY-KKNREE----LERKEKQ------------------YKKEVEAKQ-LEPTVQSLEMKS
KTARNTP-----------------------------------------------------
---------NR-DFHNHEEMK---GLMDE------NCILKADIAILRQEICTMKNDNLEK
ENKYLKDIKIVKETNAALEKYIKLNEEMIT--------ETAFRYQQELNDL-K------A
ENTRLNAE-----------------------------------LLKEKESK---------
--KRLEADIESYQSRLAAAISKH--SESVKTERNLK----LALERTRDVSV--QVEMSSA
ISKVKDENEFLT--------------------------E-QLSETQIKFNA--LKDKFRK
TR-DSLRKKSLA-LET--VQNDL--SQTQQQTQE-----MKEMYQN-AEAKV------NN
STGKWNCVEERICHLQRENAWLVQQ-LDDVHQK---EDHKEIVTNIQR----GFI-----
---ES-GKKDLVLEEKSKKLMNEC-DHLKESLFQYEREKTEGVV--SIKEDKYFQ-TS--
--RKKI------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

--------------MASAMKKIFG----VK------------------------------
---------------------------------------------------------EKT
PFGF--------------CDGPQMSISEFFF--------------GE-----CPSYPKYH
TTYRPLGQ-----IHR---------------VAAEGDA----------------------
GR---LEVLITLG-QCS--VF-DRDHK------------------DRTAL----------
----------HFAC--VYGRLPVVNVLVNNNCEIDA--LDKNHITPLMK-----------
-SVQCWKQKCAAVLL-EHGADANIRDNS----GN--CALHYAV-YNGHEDMASLLLKYHA
DIEQKTKV-Q---FTAFL------FQNL--------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-----------------------------

------------------MKKLFCFRRRKG------------------------------
--------------------------------------------------------K---
-------------------------------------------------PHNLPMGLGYD
LRDKDLKK-----LHK---------------AASVGDS----------------------
EE---LRKYLQLKK-LD--VN-MRDKE------------------YRTPL----------
----------HLAC--ANGYMNIVCLLIEKQCEINV--LDSENRSPLIK-----------
-AVQCQREDCVTVLL-SCGADPELVDFN----HN--TALHYAV-CGQSVSLVEKLLKHKA
NLEAKNKD-G---YTPLL------LAVSENNEEMVK-FLLRKGAD--------VNAT---
-DNNQR-------TA-LMIAIS--NEPT--SLVNI-------------------------
--LL-QQD-LRN--------ML-------------------------LLMVLL---CK--
--YYQLISNYGMKENS--KQMNC-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------T--------------
----------K-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-----------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TAL----------
----------HLAC--ANGHPEVVALLVDRGCQLNV--FDNKNRTALLK-----------
-AVQCQEEECATILL-ELGADPNPPDVY----GN--TALHYAI-YNEDIPMTKKLLLHHA
DIESANKV----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-----------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------MTKRKKTIN--LN-IQDAK------------------RRTAL----------
----------HWAC--VNGHEEVVTFLVDRKCQLDV--LDSEHRTPLMK-----------
-ALQCHREACANILI-DSGADLNLIDVY----GN--TALHYAV-YSEILSVVAKLLSHGA
VIEVHNKA-S---LTPLL------LSITKRSEQIVE-FLLIKNAN--------ANAV---
-NKYKC-------TA-LMLAAC--HGSS--EIVGM-------------------------
--LL-QQN-VDV--------FAAD------ICG-VTAEH---YA-VT---CGF---HH--
--IHEQIMEYIRKLSK-N-HQNT-----NPEGTS------------------------AG
TPDEAAPLAERTPDTAESLVEKTPD-EAAPLVERTPDT----------------------
-----------------------------------------------------AESLV--
--------------------------------------------EKT------PDEAAS-
--------LVEGT-SD--K--I---QCLEKAT-SGKFEQSAE--ETPRE--------ITS
PAKETSE--KFTWPAKG------------------RPRKIAWEKK-DTPREIM-------
------SPAKETSEKF-TWAAKGRP-RKIA----------WEKKE------------T--
------------------------------------------------------------
------------------------------------------------------------
-------------------------------PVK--------------------------
---------------------------T--------------GCVA--RVTSNKTKVLEK
G-------------RSKMIACP--------------------------------------
------------------------------------------------------------
-----------------------------------TKESSTKASAK--------------
------------------------------------------------------------
---------DQRFPSESKQEEDEEYSCDSRSL-FESSA----------------------
----------KIQVCI-----------------------PESIYQKVMEINKEVE-----
------------------------------------EPPKKP-----SAFKPA----IEM
-QNSVPNK-----------------------------AFELKNEQ--TLRADPM---F--
PPE-SKQKDDEENSWDSEVLCVIDFFL---------------------------------
------------------------------------VLVFP-------------------
------------------------------------------------------------
----------C-------------------------------------------------
------------------------------------------------------------
-----LPK----------ESSFFM------------------------------------
----------------------------------FCSL----------------------
--CETVSQKDVCLPKAT---HQKE---------------IDKINGKLEES-----P----
-----------------------------------------------------NKDG---
-L---------L-------KATCGMKV-SI-LTK-ALELMDMQTF-----KAE---PPEK
PSAFEPCQ--------------LKCKKSVPNKALELKNEQTLRAGE----ILPSESKQK-
---------------------DDEEN------SWD------------S---E---SLCET
VS---------------------------------------------------------Q
KDVCLPKATRQ-------------------------------------------------
----------KEIDKING------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------KLEGKN-------------------------
------------------------------------------------------------
----------------------------------QPPEKPSAFEPAIEM-----------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------QK-SVP-NKALELKNEQTLRA-
-----------------------------DQMFPSES---------KQKN----------
-------------------------------------------------------V-EEN
SWNSESLHETVSQKDVCLPKATHQKEIDKIS---GK--LED--STSLSKILDA----VHS
CERAREL---QKDH-------------------CEQLTGKMEQMKKK-------------
--FCVLK----KKLSEAK---EIKSRLENQKVK-WEQEL--CSVRLTLNQEEEKRRNADI
LN-EKIREE----LGRIEEQ------------------HRKELEVKQQLEQALRIQDMEL
KSVGSNL-----------------------------------------------------
---------NQ-VSHTHENEND---LLHE------NCMLKKEIAMLKLEIATLKHQYQEK
ENKYFEDIKILKEKNAELRMTLKLKEESLT--------KRASQYSGQLKVL-I------A
ENTILTSK-----------------------------------LK-EKQDK---------
--EILETEIESHHPRLASALQDH--DQIVTSRKSQE----LAFHIAGDACL--QRKMNVD
VSSTICNNEVLH--------------------------Q-PLSEAQRKSKS--LKINLNY
AG-DALRENTLV-SEH--AQRDQ--CETQCQMKE-----AEHMYQN-EQDDV------NK
HTEQQESLDQKLFQLQSKNMWLRQQLVHAHKKA---DNKSKITIDIHF----LE------
----R-KMQHHLLKEKNEEIFNYN-NHLKNRIYQYEKEKAETEV--SIKKYKYLSN-F--
--LK---------ESLKSYLALAKC-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----MEILLTLG-QCN--VY-HRDRK------------------DRTAL----------
----------HFAC--VYGRLPVVTILVKNNCEIDA--LDKNHTTPLMK-----------
-SVQCWKQKCATVLL-EHGADPNIRDSS----GN--SALHYAV-YNGHQEMASLLLQYNA
DIEQKTKD-G---FTPLL------LALREKRVEVAE-FLVRMGAD--------IHVV---
-DELQR-------NT-LIYAIR--CGSK--DLSVL-------------------------
--LL-EKG-IDF--------FYKD------VFG-WTALR---YA-IE---GHC---T---
--FRQTLLDFEESLHSNKKDKEPELQVEPSTSCILAK--------QIDAGNDSLARISS-
CPSPETPVLTMKED--ENSDARSN------SESKPPNCAGNSPAAIDKAFGNRGKRTVEA
W------VEKDPSS----------ESAAEVRD-----SVTNEAVERIKLLPSE-------
-------TELEL-----------------------------MSVEEDVSHESEND--HPL
RESEHLPKIKVGHSSR--SGYQ-----------MGKM---NI--NRQMKESD--EEYA--
-----------QLMTPI------------------EMKDPVSKEP-WTTKDAP-------
-------------TFKSEPDLEVTLKEDHNRFDDS-----RN------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------IQSLRIREGPPNTS-------------------------------------
------------------------------------------------------------
-----------------------------------GNVSVAADPR---RERTNRQAAESA
KEYPPLMTTN-EMKD--PDKV---VTMKEV------------------------GIVQLE
-GPA--------VKLTSEE----EP--NRQDG-FERNPPSNICKQIPAQDVGYLSI----
---AKHQRGEKMVTPR---------------EKEF--SKECP--QSKPTIVEEESVSKEA
WDMTTVKSFLEDTS-----------------NDY-------------PLSKPT----VEK
-NDYVPNE-----------------------------VSDIKHGKWFQENCPKEYVQL--
KLP-----IEERDSFPREAPPVNQAKL---------------------------------
-----------HRADEPTSVK--------NPSRITRCVRQNAAASVK---VT--SVEDQK
CPDDHE---KNQRMA-AFKRPQTKDTE---------------------YL--SMANYESR
ENFAEDQEEDPPEQQPQWK--PV--QPTLEDSSPSKASAAKPVEPFLTAEPITNISEGKQ
EWCDS-RNTQRQGIG-NLFLAEDQRY------------DSSIQDEEEDFPEEYVQLKPLD
KEKTPFPCEAPAK---KEVKTFGTELDKNL------------------------------
---SSEEEQGWLDDRE-EEHPKEPPPKDIVH-LSMSK-----------------------
----------------------DEGGVNVV----------GVISSQEKDF-PAECPEFKV
SIEKQDFVPTEDSILD--------QEKSFLAGPKTEQLRWEEEQTGWRVSD---KKQRKQ
AIFERLQLRRNT-------RVSIDPPK-SV-RSTRAAEDRGATTV-------QPRPEEDQ
TGWHAIDRKQQKPVFVRVQPRCNARTSMGPEE-SGGDTGAAQEKGATTVQLRPQEDQTGW
--------------HAIDK-KQKPIT-ERFQPRWNARVSLNPEESGEN---M---GVAEE
KGSTAVQPR-PEEDQMRWGGSEKM-------------------QWKP-VLERFQ------
--LKWSARVSVGPEKSRRH----------RGAGKDKVEPTVR------------------
----------VSSEQHSRCHSSVK-K-PRLHILE-------------RLQRKWSVRV---
----------------CM---------ETN----------QRGGKTK----------A-A
Q----MTYSSDEYPE------------LKTVIEKQDSVPVEDPEM-NHEM----------
SSAAET-DLQMKSK---EMKQTQAYENIQSVDIDQV-------SMTVGQRSKN-IVSGE-
--------EEAESDLNNASGDELNRCYS--SESNQSL--------VEEKMQKPGSNGTD-
------RDEYPSDATVS----------AAGVAGAA--AGASVGAAAGGGA----------
---AAAADGSAVVIGGGA-ASGASGGA-------PAG-------VVVGAGGVAAAAGG-S
GTDGGGGAGGNFVTAGANAD-DGGAPA--AAPTAASPAAAPTVASAAAAS----------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------A---VASAMEE-LVLQRRSGEINNQRFLTK-
---------------------ESVRH-DRPRKKTSKEKHK---ITKQVRA----------
-------------------------------------------------------M-VDV
TQLS-------------------------EA---VS--EDD--SGRPFKKQGS----LNS
DNASIDL---KKVN-------------------ELP-GKRNKKIDTE-------------
--KNDPK----KEISETR---EEKSKLEDEVVQ-GDEEF--WKLRFTLRKELEETKNIHC
IY-EIMKKH----LNEKEEQ------------------QKERATAAQ-LAMRLRTRDWEL
RIMRDTLK-ELQE-----------------------------------------------
---------------AQDQHID---AIKL------AQKMKDDLQRVEHENSELKVKVKEQ
AKKI-EK----------LSRCLQNSRERLE----------QSSKLTQSG-----------
----VRET-----------------------------------LEVLCKNN--M-----S
PMNQIGVGIHSLRSEPAQRKTVQ--DPNTSSLKSYE---------------------QQC
IDELRISNALLYERYNLYRNKRLEESRTKVHITVEQDTS-PLSTSETRFDLESPCVACSC
PHQYVFPREAGV-LPG--NPRSSNYSSQRCH-RT-----MEDEE-----KSV------KE
LTELKQTLEYKLYHQKKKNGEIEKEII-----------------------------GIKK
CL-KM-TKTGH-------KIGECS-SHGHSRTVQF-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TAL----------
----------HLAC--ATGQPKMVFLLVSRRCELNM--QDRECRTPLIK-----------
-AVQLRQEACATILL-QNGADPNIMDFF----GR--TALHYAV-YNEDTSMIEKLLLYGT
NIEECSKY-K---YPPLL------LAVSKRKLKMVE-VLLKKNAN--------INAI---
-DYLSR-------SA-LILAVT--LGEK--DIVI-L------------------------
---L-QHN-IDV--------FSRD------AYG-KTAED---YA-IE---AEN---RV--
--IFELISEYKRKK-YEELSINS-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------N--------------
----------PG--KI--S-------------------------DSELLLM---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------VLP----
------------------------------------------------------------
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-----------------------------

------------------MKKIFGFRS-KG------------------------------
--------------------------------------------------------PSPL
GPSG----------------GSRSNCVGFGR----------------ESA-SGSHVPRYH
IHDKDMGK-----IHK---------------AASVGDV----------------------
AK---VQHILILGK-SG--VN-DRDKK------------------DRTAL----------
----------HLAC--AYGHPEVVTLLVERKCEIDA--RDSENNTALIK-----------
-AVQCQEEECAAILL-DHGADPNVVDSS----GN--TALHYAV-YSESTSIAAKLLAHSA
NIEAKNED-D---LTPML------LAVKENKQHIVE-FLVKKKAS--------IHAV---
-DQLGS-------N--RQIFEY--DGKR---LK-SSENSNPVDNGSED------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------GSLTRSYN--TPGP--------------A----D--SWPTSDE---------
--------EDYSFDTKN-------------------VPKINLTELWTAAQQSKKN----Q
TKCGFKEL------------------DNGARFDDSNSTSE--------------------
---------------------S-------------------DDAI---------------
------------------------------------------------------------
-----------------------------EIESA--------------------------
----------------------------------PPVRVQTL-SPS--RQSPDP------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------VLGAPEPAIEGEE---------
---NGTDIIE----STSQE--------------QPNRDN-------------LTRADGWH
KSN----KSEMMSALGLGEDEDEDSPWDSESV-SESVSLKDVG---------------HL
SGTADQTGKRRVHG---Q------IED----------------------------VTYVP
SCMSGSRSFKMAKLEESRNV--------------GIPVAHMEAPRKYAIMEPA----MER
-RAPALNRTE---------------------------TVGRK------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------DAQT----------------
--------------------------------------------V---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------KS
EP--ETVSREEQTRLSG-------------SEDTQQKV---------EE-KTYK------
---------------------------NNEAELS---GSLYSGAADSG------------
------A-AVKP-----------QNGDTD----NQQAPREGTEGR-----------G---
-----------SGPALPMKE-AKKMGN--EKWVSREPARTAVSECA--------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------GLPQMQDGSCWSD-
-------------------TDQSEA---RPTKKTSSKHNK---DSGQTAAVD--------
------------------------------------------------------NL-DDF
TESSETASEDHELQ--GPDYESILCEIEHLR---LE--CKD--TVSLLKIRDA----IYS
YKRLIEL---KRSH-------------------CELLTGKLKRMENK-------------
--YKGLQ----KEVSETE---DVKSRLEHEKVG-WEQEL--CRLRFALKQEEEKRRSADQ
LS-EKTMEQ----LRRKGEQ------------------CQSEVEARQQLEASLRTLEMEL
KTVKSHLS-QVLEERNETQRQLSREQNARMLQDGIL-----ASHLCK--QKEIEMTQ---
-KKMTSEVSV-----SHEKEKD---LLHK------NQRLQDEVAVLRLEMDTIQNHNQEK
EKRYLEDIKIANEKSDNLQRMIKLNEETFT--------KTIFQYSGQLNSL-K------T
ENTMLSSK-----------------------------------LDNEKQNK---------
--ERLETDVESFRSRLASALHDH--AEIQTAKRDLE----IAFQRARDEWFRLKEKMNFD
MSNLRDNNEVLS--------------------------Q-QLSKTERKLNS--LEIEFHH
TK-DELREKTLA-LKH--AQRDL--SQTQCQMKE-----VEHMFQD-EQGKV------SK
FMGKQESIEERLAQLQSENTLLRQQLDDAANKA---ESKDKTIVNIQD----QFQDVLNR
FQAES-QRHSLRLEDRNQELISEC-SHLKERMCRYENEKAER EV--VVRQLQQELADT--
--LKKQ------SMSEASLEVSSRYRSNLEEEVRDLKKKLGQIRSQ-LQEAQDQHREAVQ
H-----------------------------------AEKMEDHLQKLELEKSTFEITIKK
QSEEIEQLQ----ENLSRV-----------------------------------------
------------------------------NLSEEDKE-KLQKL---TELKESLEYT-LD
QEQKRSGALEKELTEFKEV-----LKMTK--------------KELSE------YENR--
--EL-NLRQDIKSNQLEMDIPVNTLIKKIDDLTAKLESTSSKCLHLGKK-----------
-NQLL--QQELLLMRTIQKKCGKLEKNKKQLEQEVMNLRSH---MEK-NMVEHSQAQQY-
AREVEERARQDL-VEKLKQVNL---FLQAQAA-SQENLEQ-LREN-SNASV RSQMELRIK
DLESQL-YKLKA-QE------DLDKIELEKYK----QLYQEEFRARKALS-SKLNKTSEK
LEEASTKLLLEEQQ---NRSLLS------TLSTRPVVECPCVGNLHNSLVFNRTLIPREN
IVV-PTSGLQPSNKR-VEIYLTKMHQELEKSINRELKEA-AAE-----LES-----E---
--------------------SCRVSPLGPA---------AKP------SQDLLSGASQEY
IDILKRK--YMIC-----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TAL----------
----------HLAC--ASGHPEVVTLLVERKCLLNA--YDSENRTPLMK-----------
-AIQCQEEECATILL-EHGANPNLTDTF----GN--SALHYAV-YGQNRALVEKLLLRHA
DIEARNKN-G---LTPLL------LAISENKEEMVE-ILVKKEAS--------TRAV---
-DETKX-------XX-XXXXXX--XXXX--XXXXXXXXXXX-------------------
---X-XXX-XXX--XXXXXXXXXX------XXX-XXXNQQLIYE-YR-------------
------------------EEKKC-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------K--------------
----------V-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------MKKIF---SKKG------------------------------
--------------------------------------------------------ESPL
GSFA----------------RRRRSSAGGGG----------------EPGEGAYSQPGYH
VRDRDLGK-----IHK---------------AASAGNV----------------------
AK---VQQILLLRK-SG--LN-DRDKM------------------NRTAL----------
----------HLAC--ASGHPEVVTLLVDRKCQLNV--CDNENRTALMK-----------
-AVQCQEEECASILL-EHGADPNLADVH----GN--TALHYAV-YNEDIPLATKLLLYDA
NIEAKNKD-D---LTPLL------LAVNGKKQQMVE-FLIKKKAN--------VNAV---
-DKLES-------SH-QLISEY--KEER--IPKNSSQNSNSVDDSSED------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------SLSRLSG--KPGV--------------D----D--SWPTSDD---------
--------EDLNFDTKN-------------------VPKPSLAKLMTASQQSRK---NLE
ATYGIVRT------------------GSRTLFEDRDSDSQ--------------------
---------------------D-------------------EVVC---------------
------------------------------------------------------------
-----------------------------ESLPT--------------------------
----------------------------------TSVKVQGFSHPT--CQSPDPLP-KPS
HKS---------------------------------------------------------
----------------------------------------LANP----------------
-----------------------------------GLIKEGPKKPAIGKKE---------
---NGIDIIE----SAPLE--------------QTNNDN-------------LTYVDEVH
KNN----RSDMMSALGLGQEEDIESPWDSESI-SENFPQKYVD---------------PL
AGAADRKEKNMGNE---Q------AED----------------------------VFYIP
SCMSGSRNFKMAKLEDTRNV--------------GMPVAHMESPERYLHLKPT----IEM
-KDSVPNK-----------------------------AGGTK------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------DV------------------
---------------------------------------------QTSK-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------AA
EHDLEVASEEEQER-KE-------------SENNQPQVE--------EERKKHR------
---------------------------NSEMEVS---ANIHDGATDDD------------
-----EDDGLIQ---------ERRSGETD----HQQFPRKENKEY---------------
---------AGSGPALQMKE-VKR--------TSKESVNSPVFEKASLL-----------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------TGGLLQVDDDSSLSE-
-------------------IDEDEE---RPSKKTSNEKNK---VKNQIQSVD--------
------------------------------------------------------DV-DDL
TQSSETASEDCELP--HCSYKNFMLLIEQLG---ME--YKD--SVSLLKIQDA----ALS
CERLLEL---KKNH-------------------CELLTVKIKKMEDK-------------
--VNVLQ----KELSETK---EIKSQLEHQKVE-WEREL--CSLRFSLNQEEEKRRNADM
LY-EKIREQ----LRRKEEQ------------------YRKEVEVKQQLELSLQTLEMEL
RTVKSNLN-QVVQERNDTQRQLSREQNARMLQDGIL-----TNHLSK--QKEIEMTQ---
-RKMNSENSH-----SHEEEKD---LLHK------NSMLQEEIAMLRLEIDTIKNQNQEK
EKKCFEDLEIVKEKNEDLQKTIKQNEETLT--------QTISQYNGRLSVL-T------A
ENAMLNSK-----------------------------------LENEKQSK---------
--ERLEAEVESYRSRLAAAIHDR--DQSETSKRDLE----IAFQRARDEWSRLQDKMNFD
ASNLKDNNEILS--------------------------Q-QLFKTESKLNS--LEIELHH
TR-DALREKTLG-LER--VQKDL--SQTQCRMKE-----MEQKYQN-EQVKV------NK
YIGKQESVEERLSQLQSENMLLRQQLDDAHNKA---DNKEKTVINIQD----QFHAIVQK
LQAES-EKQSLLLEERNKELISEC-NHLKERQYQYENEKAER EV--VVRQLQQELADT--
--LKKQ------SMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQ-LQEAQDQHTEAVR
C-----------------------------------AEKMQDHKQKLEKDNAKLKVTIKK
QMEKIEELQ----KNLLNA-----------------------------------------
------------------------------NLSEDEKE-QLKKL---TELKQSLECN-LD
QEMKKNVELEREITGFKNL-----LKMTR--------------KKLNE------YENG--
--EF-SFHGDLKSSQFEMDIQINKLKHKIDDLTAELETAGSKCLHLDTK-----------
-NQVL--QQELLSMKTIQKKCEKLQKNKKKLEQEVINLRSH---IER-NMVELGQVKQY-
KQEIEERARQEI-VEKLKEVNL---FLQAQAA-SQENLEQ-LREN-NFASM KSQMELRIK
DLESEL-SKIKTSQE------DFNKTELEKYK----QLYLEELKVRKSLS-NKLNKTNER
LAEVSTKLLVEKQQ---SRSLFT------TLTTRPVMEPPCVGNLNNSLYHNRKLIPREN
SVI-SSSKPRTSNNS-VENYLSKMQQELEKNITRELKEA-AAE-----LES-----G---
--------------------S-IASPLGST---------DES----NPNQDLVLKASREY
VQILKKN--YMI------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------MRKLFSFGRGLG------------------------------
--------------------------------------------------------QALL
SS----------------------------------------------RD-KEYAGPGYH
TLDWELRK-----IHR---------------AAIKGDA----------------------
AE---VERCL-RRF-RD--VD-ARDRK------------------DRTVL----------
----------HLAC--AHGRVEVVTLLLSRSCQIDI--CDRLNRTPLMK-----------
-AVHCQEEACAIILL-EHGANPNIKDIY----GN--TALHYAV-YNKGTSLAEKLLSHHA
NIEALNEE-G---NTPLL------FAINSRRQQMVE-FLLKNQAN--------IHAV---
-DNFRR-------TA-LMLAVQ--HSSS--SIVSL-------------------------
--LL-QQS-INI--------FSQD------MFG-QTAED---YA-VC---CDL---RR--
--YMLILG----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
-----------------------------

------------------MRRLFSFGRRLG------------------------------
--------------------------------------------------------QMLL
SS----------------------------------------------RD-EEYAGRGYH
TLDWELRK-----IHR---------------AAIKGDA----------------------
AE---VERCL-RRF-RD--VD-ARDRK------------------DRTVL----------
----------HLAC--AHGHVEVVTLLLSRSCQIDI--CDRLNRTPLMK-----------
-AVHCQEEACAIILL-EHGANPNIKDIY----GN--TALHYAV-YNKGTSLAEKLLSHHA
NIEALNEE-G---NTPLL------FAINSRRQQMVE-FLLKNQAN--------IHAI---
-DNFRR-------TA-LMLAVQ--HSSS--SIVSL-------------------------
--LL-QQN-INI--------FSQD------MFG-QTAED---YA-VC---CDL---RS--
--IQQQIL---E------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------H--------------
------------------------------------------------------------
-------------K-----------------------------NK-------I-------
-----------------------------LK----------NHLR---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------N----------------------------------------------------
------------DNQETAA-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------VK-------------------------------------------PA-------
------------------------------------------------------------
-------------------------------------------------NL--E------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------K
------------------------------------------------------------
----------------------------RK-------EGAK-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------EHNLKVASEEKQERLER--SGNKQPQDS---------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------QSYGRKKD---VMYG------NYMLKRDIAMLKQELYTIKNDSLRK
EKEYFQEIKSITEMNANFEKSVRLNDEMVT--------KTTAQYSQQLNEL-K------A
ENTRLNSK-----------------------------------LEKEKHNK---------
--ARLEAEVESLHSSLATAINEY--NDILER-KDLE----LVLWRADDVSG--HGKMDSN
ISQLTDKNKLLT--------------------------E-QLSKARVKFNT--LKGKLHE
TR-DALKEKTLA-LES--VQIDL--KQTQYRLKE-----MKQMHPN-EEAKE------SQ
SFGKQNSLEERRHQQEPENLLLEQQ-LKDAYKE---GNNKEIVINIQE----DRL-----
---EN-GKEDLT-EEKNTELTNEY-NYLKEKLFQYEKEEAEGEV--IVRRLQEELADH--
--LNKF------SMSESPLEGTSHCHINLDE-TRASKKKLFQVGSQ-PEEKHEEFR----
------------------------------------------------------------
-------------K----------------------------------------------
-------------------------------------------L---FELISSLDYN-VD
QIREKNNKLEEETTGYKKC-----LEMTI--------------NMLNV------FGNE--
--DF-SCHGDLNTDQLKMDVLFKKLKQKFDDLTAEKEAVSSKCVSLAKD-----------
-NQVL--QQEFLSMRKIQEKCEKLEEDKKMLEEEVLTLKTH---MEN-NMVELGKVQEY-
KSELDEKTMQII-EKLEEI------HLQEQAK-YEKQLEQ-LNKD-NTASL-NKKELTLT
DVECKF-SNMKTAYEE-----V--TTELEEYK----EAFAVALKAHNSMS-KNLTKSNKK
IAVISTKLLMEKER---MKYFLS------TLPTRPDPELPCIENLNSIG-LNKKDISKTP
VRI-PTSNPQTSNNC--ENSLTEVEPDCVEQIIRETKKT-FAV-----LGT---------
CSHLLSSLESTGP-----------E-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------MER-LSAALKGQ------------------------------
--------------------------------------------------------TGPE
RPSP-------------------------------------------F-----------M
IHHGDLRK-----IHK---------------AASRGQA----------------------
WK---PERM-MKKTTMDLN---IRDAK------------------KRTAL----------
----------HWAC--ANGHAKVVTLLVDRKCQLDV--LDGENRTILMK-----------
-ALQCQREACANILI-DSGADPNIVDV-------------------ENLSVVAKLLSCGA
DIEVKNKA-G---HTPLL------LAIRKRSEKIVK-FLLTKNAN--------ANAV---
-DKFKC------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------V--H-------------------------QQLLEYKQ--------
-----------K------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--ISKNSQ-------------------------------------------NS-------
------------------------------------------------------------
-------------------------------------------------NP---EGTSEG
TPDEA-------------------------------------------------------
-------------VPLAER-------------------------------------T-PD
TAE---------------------------------------------------------
------------------------------------------------------------
-------------------SLV--ERTPDE------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
-----------------------------

------------------MKKI---FSKKGES-PLA------------------------
------------------------------------------------------S-----
------------------FSSRRRTGA-------------GVGC---EHGNGVYSQPGYH
VRDRDLGK-----IHK---------------AASLGQV----------------------
AK---VQQILLLRI-NG--LN-DRDKM------------------IGLTV----------
----------KSSLGVSFSKAQFYFSIVDLKCILLF--SLIEDGS---------------
--------------------S------------------EDSL-IPFSFSFFEMG-----
------SR-----F---V------------AWVSVQ-WHQHS------------------
----------------SLQPQ---------------TLEL--------------------
---------KRS--------SYLS------LP----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------SSWDYRLSD--KPGI------------------DD--SWPTSDDED-------
----------LDFDTKN-----VPK--------------PSLTKLMTA------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------S--QQSRKNLE---AQYGTVRM
ESAILTEDRI----------SESPKEEVVEGLPSRPVKVQAFAHPA--FPSPGP-RPKPS
LTAL--------------------------------------------------------
------------------------------------------------------------
--------------------------------ANRGLTEEGTTKPATGKKE---------
---NGVGID-----SPLAEQT----------------DDNL-------------TFDGVC
KNN----RSDMMSALGLGQEEDIESPWDSESI-SENLPQKYVD--H-------------L
SGAA--------------------------------------------------DQ----
------------------------------------------------------------
-------------------------------------------KE-----EDTVNGQV--
EG---NNPF------IC---CKSFILT---------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------QNM----D-----LSAEHDLEEVT-SEE-----------
----------------------------------EQ-ES-L--EG-R-------------
--------------------------------------ENNEPWVEEERKKH---KSKEM
EVSE-----------NLYDGAAAA------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------ADGGF-IQQR----------
--KSGK------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------TDDQQFTRKEKEKC---------------
-------DS--SGPASHMTE-VRKNDNE--KWTPKESVMTPVF-----------EK----
----------------------ASLPTGGLL-----------------------------
-----------------------------------RG--NDDS----S------------
------------------------------------------------------------
----------------LKLFFLLP------------------------------------
------------------------------------------------------------
-------------------------HFQNYG---LP--CN--HILYFKKFISDHVTPLFK
TQLSLLI---ARSTC----------------GACFSILGILHL-----------------
---------------------------VECKTN-LKISI--FNCRFTLKQEEEKKRNADM
LY-EKNREQ----LRRKEEQ------------------YRKEVEAKQQLELTLRTLDMEL
RTVRNNLD-QVNQSLVVV-RQL---------QQELA---------DT--LKKQS------
----MSEASLE-VSHSHENEED---LLHK------NHMLQDEIAMLRLEIDTIKIQNQEK
EKKYFEDIEIVKEKNDDLQKTIKLNEETLT--------KTISQYSGQLSVL-TA------
ENTMLNSK-----------------------------------LENEKQTK---------
--ERLETEVESYRSRLAAAMHDC--DQSQTSKRDLE----LAFQRAREEWFRLQDKMNFD
VSNLKDNNEILS--------------------------Q-QLSRTESKFNS--LEIELHH
TR-DALREKTLV-LEG--VQRDL--SQTQSQMKE-----IEQMYQN-EQGKV------NK
YIGKQESVEERLSQLQSENMLLRQQLDDAQNKA---DNKEKTVISIQD----QFHAIVKK
LEAES-EKQSLLLEERNKELINEC-NHLKERQYQYENEKAER EV--SIKKEI--------
------------------------------------FFRLPERKFR-LEEARDQHAEAVR
CAER-----------------------------------TQDHMQKLEKENSKLKVTIKK
QADKIERLQ----KNLLSASSCE-------------------------------------
-------------------------------DE---KE-ELKKL---TELKQSLEYN-LD
QEVKKNDELEKELSGFKN-----LLKMTR--------------KKLNE------YENGD-
---F-SVCGDLKTSRFETDVQINKLKHKIDDLTAELETASSKCLHLDTK-----------
-NQTL--RQELSSMKTIQKKCEKLQKNKTKLEQEVVNLKSH---IEI-NMVELGQVEQY-
KREIEERARQDI-VEKLKEVNL---FLQTQAA-SQENLEQ-LREN-HIASI RSQMELRIK
DLESEL-SKMKTSQEDF------NKMELEKYK----QLYLEELKFRKSLA-TKLNKTNEK
LAEVSTKLLVEKQQ---TRSLFT------TLATRPVLESPCVGNLNNGLVLNRKLIPREN
LVI-PTSSPRTSNNS-MENYLTKMQQELEKNITRELEEA-AAE-----LET-----E---
--------------------SYIASPVGST---------DES----NLNQDLVWKASREY
VQILKKN--YMI------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------IKK---------------------------------------
------------------------------------------------------------
---L--------------FSFWWEDESC-----------------------------GHS
LLDGDLKK-----LLX---------------XXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XV---LSPCLF---LSH--AT-TLNYF------------------IRTPL----------
----------HLVY--ASGYTNTVSLLVEKHFKISV--QDREDRFLLIE-----------
-AVQCQKENCA-IFL-NHGADPKLVDFE----FS--AVHHYAV-CAHIVSLV-----EKP
NLQGQNQD-V---YTPVL------LAITEKDVETVE-FLLKKVAN--------VNAL---
-NNSQ-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
-----------------------------

------------------MKRIF------K------------------------------
---------------------------------------------------------GHS
PW----------------------GFLSFRH--------------------ENQEPSWYL
TGYTPVKK-----IHK---------------AASMGDI----------------------
AQ---VQRMLEFG-DVD--VN-ITDRK------------------KRTAL----------
----------HYAC--AHGQSEMVTLLLWYACNIEA--RDREESTALIK-----------
-ATQRQHEECVKILL-ENGADPNPVDIN----QS--TALHYAV-YNNTTSIAARLLAFNA
DTETKTKN-G---YTPLI------LAVLENKQEMVE-LLLQAAAN--------INAL---
-DNCKR-------SA-LIHAMR--AQSK--NIISL-------------------------
--LL-QQG-ADA--------SLMD------VYG-ATAQS---HT-GF---E---------
-GC---------------------------------------------------------
KPCPP-RDSEIFNLRM-----------------------------MAQLPENTDAADK--
------------------------------------------------------------
--------------------------------------LGRYSCLHIP------------
---------------------L-------------------V--K--TSSRV--LLWD--
-----------GCS--S------------------SVTLNL-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------MLIASAIRRLFGLSSRGR------------------------------
--------------------------------------------------------V-P-
--------------------------------------------SDPSGLQGSCGDLQHR
ARPKAVDK-----LHK---------------AASGGDT----------------------
TK---VDWSLLLRK-NG--VN-DRDKK------------------HRTAL----------
----------HFAC--VYGHPEVVTLLVEHKCDIDA--RDRENSTALIK-----------
-AVQYHQEECATILL-EHGANPNVADAS----GN--TALHYAV-YWENSSIAAKLLSHHA
DTEAKNKV----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------MRKLFSFGRRLG------------------------------
--------------------------------------------------------QALL
SS----------------------------------------------MD-QEYAGPGYD
IRDWELRK-----IHR---------------AAIKGDA----------------------
AE---VERCLTRRF-RD--LD-ARDRK------------------DRTVL----------
----------HLAC--AHGRVQVVTLLLHRRCQIDI--CDRLNRTPLMK-----------
-AVHSQEEACAIVLL-ECGANPNIEDIY----GN--TALHYAV-YNKGTSLAERLLSHHA
NIEALNKE-G---NTPLL------FAINSRRQHMVE-FLLKNQAN--------IHAV---
-DNFKR-------TA-LILAVQ--HNLS--SIVTL-------------------------
--LL-QQN-IRI--------SSQD------MFG-QTAED---YA-LC---SDL---RS--
--IRQQILEHKNKMLKNHLRNDN-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------Q--------------
----------E----T--A-----------------------------------------
-------------------------------------------AM-------K-------
-----------------------------PAN----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------LKKRKERA---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------KAEHNLKVASEEKQERLQR--SENKQPQDS---------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------QSYGKKKD---AMYG------NFMLKKDIAMLKEELYAIKNDSLRK
EKKYIQEIKSITEINANFEKSVRLNEKMIT--------KTVARYSQQLNDL-K------A
ENARLNSE-----------------------------------LEKEKHNK---------
--ERLEAEVESLHSSLATAINEY--NEIVER-KDLE----LVLWRADDVSR--HEKMGSN
ISQLTDKNELLT--------------------------E-QVHKARVKFNT--LKGKLRE
TR-DALREKTLA-LGS--VQLDL--RQAQHRIKE-----MKQMHPN-GEAKE------SQ
SIGKQNSLEERIRQQELENLLLERQ-LEDARKE---GDNKEIVINIHR----DCL-----
---EN-GKEDLL-EERNKELMKEY-NYLKEKLLQCEKEKAER EV--IVREFQEELVDH--
--LKTF------SISESPLEGTSHCHINLNE-TWTSKKKLFQVEIQ-PEEKHEEFR----
------------------------------------------------------------
-------------K----------------------------------------------
-------------------------------------------L---FELISLLNYT-AD
QIRKKNRELEEEATGYKKC-----LEMTI--------------NMLNA------FANE--
--DF-SCHGDLNTDQLKMDILFKKLKQKFNDLVAEKEAVSSECVNLAKD-----------
-NEVL--HQELLSMRNVQEKCEKLEKDKKMLEEEVLNLKTH---MEK-DMVELGKLQEY-
KSELDERAVQEI-EKLEEI------HLQKQAE-YEKQLEQ-LNKD-NTASL-K KKELTLK
DVECKF-SKMKTAYEE-----V--TTELEEFK----EAFAGAVKANNSMS-KKLMKSDKK
IAVISTKLFTEKQR---MKYFLS------TLPTRPEPELPCVENLNSIE-LNRKYIPKTA
IRI-PTSNPQTSNNC--KNFLTEVLLC---------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------MER-LSAALKGQ------------------------------
--------------------------------------------------------TGPE
RPSP-------------------------------------------F-----------M
IHHGDLRK-----IHK---------------AASRGQA----------------------
WK---PERM-MKKTTMDLN---IRDAK------------------KRTAL----------
----------HWAC--ANGHAEVVTLLVDRKCQLDV--LDGENRTILMK-----------
-ALQCQREACANILI-DSGADPNIVDV-------------------ENLSVVAKLLSCGA
DIEVKNKA-G---HTPLL------LAIRKRSEKIVK-FLLTKNAN--------ANAV---
-DKFKC------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------V--H-------------------------QQLLEYKQ--------
-----------K------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--ISKNSQ-------------------------------------------NS-------
------------------------------------------------------------
-------------------------------------------------NP---EGTSEG
TPGEA-------------------------------------------------------
-------------VPLAER-------------------------------------T-PD
TAE---------------------------------------------------------
------------------------------------------------------------
-------------------SLV--ERTPDE------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------MRKLFSFGRRLG------------------------------
--------------------------------------------------------QALL
SS----------------------------------------------RD-KEYAGPGYH
IRDWELRK-----IHR---------------AAIKGHA----------------------
AE---VERCL-RRF-RY--VD-ARDRK------------------DRTVL----------
----------HLAC--AHGRVEVVTLLLSRSCQIDI--CDRLNRTPLIK-----------
-AVHCQEEACDIYGNTALHYAPNIKDIY----GN--TALHYAM-YNKGTSLAEKLLSHLL
L-------------------------------------------------------F---
-LCYFR-------TA-LMLAVQ--HNSS--SIISL-------------------------
--LL-QKN-VNI--------FSQD------MFG-QTAED---YA-VC---CDL---RR--
--YMLILG----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------MKKIFGFGSRKG------------------------------
--------------------------------------------------------ESPL
GSLT--------------SRQRT--------GV----------GVRPETGNRVTLGPGYH
IRDKDLGK-----IHK---------------AASVGNV----------------------
RK---VQRILLLRL-NG--LN-DRDRM------------------NRTAL----------
----------HLAC--ANGHPEVVTLLADRKCQLNL--CDNENRTALIK-----------
-AVQCQEEECATILL-EHGADPNIMDTD----GN--TALHYAV-TGQNMNIAAKLLLYKA
DTEARNKD-D---LTPLL------LAINENKQQMVE-FLVKRNEN--------VHAV---
-DKMKS-------NC-KLPSDY--KEEW--GYKRSSQNSNLAGTSIRITRLAE----GTA
A-EV-DES-SEEDSVSSLFSKPGV------DDS-WPTSEDEDFD-FD---SRK---EA--
--TKAAI-----------AKKEN-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------G--------------
----------ID--II--E-------------------------SAPQEQT---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----NND-------------------------------------------N--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------LKRIFGLSS-KG------------------------------
--------------------------------------------------------RAPS
SPADP-----------------RSS----------------------------CRDARHG
VVDMAVGK-----LHK---------------AASGGDV----------------------
AR---VQHLLLLGK-SG--LN-DRDKK------------------HRTAL----------
----------HFAC--AYGHPEVVTLLVERKCDIDA--CDNDNNTALIK-----------
-AVQCDHEECATILL-EHGANPDVADAR----GN--TALHYAI-YSENTSIAAKLLSHNA
NTDAKNKD-G---LTPLL------LALKENRLEVAE-LFEKKKTD--------INML---
-DKPGR-------YSLFLSFFN--K----------------TLVNSED------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------DSLTSFSN--KHDP--------------D----D--SWPTSDD---------
--------DDCVFDNKN-------------------VPKVNLTELWTAAQQSKKN----R
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------PVIRMTE---------
---TDTFVVE----NASQE---------------QTNDN-------------MTNIDGGQ
KDY----KTDMMFALGLGDE-D-ESPWDSESI-SENLPQKSVD---------------PL
SVAADERGKHTGNG---Q------VED----------------------------VVYIP
SCMSGSRNFKMAKLEDTGNV--------------GKPITKKTLIFLIFF-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------FFF---------------
---------LSSGPAFPLWK-VNKTEN--EQWSSTESVISPVLKKASSL-----------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------SGGLLQVKSD------
---------------------------------------I---VKKQIHAVD--------
------------------------------------------------------YL-DDL
SQSSETPSEDSESP--YPNYENILLLFEQLR---ME--CKD--SISILKIWDA----IRS
YKTVMEL---KKDH-------------------DELLTGKIKKLENK-------------
--LRELQ----KELTETK---DAKSQLEHEKIQ-REREL--GDLRFVLKQEEEKRKNVDQ
FY-EKTKEQ----LRKKEEQ------------------YYQEVEAKQQLEISLRTLDTEL
KTVRNKLD-QVLEERNDTQRQLSREQNARMLQDRIL-----ESHLCE--QKEIEVTQ---
-EKMNPEVSV-----SN---ED---LLHK------NQRLQNEIAMIRLEIDAIKNQNQEK
EKKYLEDIEVANEKNDALQRTIKLNEETFA--------KTVFQCNGQLHIL-T------A
ENTMLNSK-----------------------------------LENEKQNK---------
--ERLETEIESYRSRLASAVHDY--DESQTSKRDLE----LAFQRARDEWFRLQDKMNSD
MSNLKDNNEILA--------------------------H-QLSKAERKFNS--LEIEFHH
AR-DALREKTSV-LEQ--VQRDL--NQTQCEMKE-----FKHMYQD-EQGKV------NQ
YMGKQESMMERLSQLQSENALLRQQLDDAHNKV---DFKEKTVINIQD----QFQDIVKT
LQGES-EKQNLMLEDRNKELLHEH-NCLKERLCQYEKEKAER EV--VVRQLQQELADT--
--LKKQ------SMSEASLEVSSRYRISLEDETQDLKKKLDQIRSQ-LEEERHQRMEAVQ
C-----------------------------------AEKMQEHLQKLELENSRLKAKIKK
QAGKIEHLQ----KNLLSA-----------------------------------------
------------------------------NLSEDDKE-QLKKY---AELKQALEYN-LD
QEKKKNDELKKELTRFKKL-----FKMTE--------------AKLNE------QESG--
--EF-RFHGDLKSNELEMNIPIKTLIHKIDGLAAKLEATSSKCLHLDKN-----------
-NEFL--HQELLSMKNIQKNCETLEENKKKLEQEVVNLKSH---LEK-NVVEHGQLEQY-
KREIEERARRDL-LEKLKQVNL---FLQTQAA-SQEHLEQ-LRES-NNASM RNQMELRIK
DLELEL-SKTKT-EE------DFNKIQLEKYR----QLYMEEFRTRKSLS-SKLNKARER
LEEANTELLVEKQQ---SRSLLS------TVSTRPVLECPCVGNLNHSLTLHRSFLPRES
LVV-HTLNPQPSNDS-IENYLTKMRQELENSITRAAREA-TAE-----IES-----A---
--------------------VLKFSPRRLT---------NKS------SQDLISETSQEY
KEILRRR--YMI------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TAL----------
----------HLAS--ANGNSEVVKLLLDRQCQLNV--LDNKNRTALTK-----------
-AIQCQEDECALMLL-EHGTDPNIPDEF----GN--TALHYAV-YNEDKLMAKALLLHGA
AIESKNKH-G---LTPLL------LGVHEQKQQVVK-FLIKKKAN--------LNAL---
-DRYGR-------TA-LILAVR--CGS-A-SIVSL-------------------------
--LL-EQN-IDV--------SSQD------LSG-QTTRE---YA-VS---SHH---NV--
--ICQLFSDYKEKRMLKISSEN--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------SNPS------------
-------------------------------------Q------------RLK-------
--------------------------------GSENS-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------QPE--------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------KMSEEPEINK-----------
---DCDREVE--------------------------------------------------
----------EVKKHG--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----SNH------------------------------VGLP------------------
------------------------------------------------------------
-----------------------------------------E-------NL---------
--------------------------------------------------ADG-------
------------------------------------AAA---------------------
---G---------NG---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------D-DGLI---------------------------P----
----Q-------------------------------------------------SKSRTP
----------------------------------------GSQ-----------------
--QFPDTE------------------------------------------------NE--
------------------E-----------------------------------------
----------------------------------------------------CH------
------------------------------------------------------------
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-----------------------------

------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------PGYR
IRDKDLRK-----IHK---------------AAIVGNV----------------------
AK---VQLVLLFGK-NG--LN-DRGKM------------------NRTAL----------
----------HLAC--ANGHSA-ITLLLERKCLLNL--CDNENRTALMR-----------
-AIECQEEECATLLL-EHGADPNVMDIC----GN--TALHYQ-----NVSLAAKLLSCDT
NIEARNKD-D---LTPLL------LAICESRGQMYA-DVIRLQKS--------RSKK---
-D--------------------------------------SFGRKTTAL-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------M---------
--------LAIKYESAN-------------------VIR-----LL--------------
------------------------------------------------------------
--------------------------------------------LQ--------------
------------------------------------------------------------
-----------------------------QG-----------------------------
--------------------------------------ADIFSQDV--FGWPVEE-----
------------------------------------------------------------
----------------------------------------YAV-----------------
------------------------------------------------------------
------------------------------------------------------------
-----------IS--GFNIFCQL--------------ISEYKE-----------------
-----KRS----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------KS-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------S---A----ENSNPG
EQYLEMITEEEQEKPDE-------------DENNYAQV---------EEEKKHK------
---------------------------GSEVEVS---ENMCYAA----------------
-----DESGLFQ---------QRKSGGNS----NQEFPAMQNEGS---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------DKPARKTPYEKKK---VKEQINYVN--------
------------------------------------------------------KL-DSF
----ETVSEDGDVL--S--STNSTLQVEPLN---VG--CKD--SVSLLKIQDT----ILL
HERLVYFQSSQRSH-------------------CELLRGEFYRMKSK-------------
--VRELQ----KELSETK---EVKSQSIRKWTGNKRKSF--KFCRFTLKQEEEHRRNAKM
LY-EKMRQH----LRRK-DQ------------------YSKEVEVKQHLELTFQAVEVIV
KTGRARSN-QN-------------------------------------------------
-------------HYSCEETKD---LLHK------KHMLQDETAMLRLEIDALKNQHREK
EENYFEDVEILKVKNDDLQKAIKLNEESLT--------KTISHYTGQLNAL-T------A
ENTMLNSK-----------------------------------LENEKESK---------
--QRLETEVKSYRSRLATALHDH--DQGQTSKSDLE----LAFQRARDEWLCLWDKMKYD
VANLKDNNEMLS--------------------------Q-QLSTVESVFNK--LKIKLHH
MR-DDLREKTLM-LER--VQRDL--SQSECQKQE-----IEHMYQN-EQGKV------NT
YLGKQECLEERLSQLQSENMLLRQQLGNAQNRA---ESKEKTVISIQD----QFQQIVRK
LQAKY-EKQGLMLEKRNKELIKEW-NYLKERMYWYENEKAEEVS--IQ----KE------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------MNKLFSCWKRRN------------------------------
--------------------------------------------------------ETP-
-------------------------------------------------------SQGYK
LLDKDVKK-----LHR---------------AASLGDL----------------------
KK---LKKYIQVKK-YD--VN-SQDEE------------------YRTPL----------
----------HLAC--ANGHTNVVLFLIEQKCKINV--QDSENKSPLIV-----------
-AVQCQKEDCANILL-NCGADPNLMDVC----YN--TALHYAV-CGQSFSLVEKLLEHKA
DLEAKNKD-G---YTPLL------LAVIKCNPKMLK-FLLDKGAD--------VNAT---
-DNYQR-------TA-LIIAVS--GEAT--CVQRS-------------------------
--LL-QQG-VEL--------SCED------VMDSQLRNM---LF-SM---VLL---YT--
--HNQWQVMERRKMLS--RHLIL-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------G--------------
----------TT--CD--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------MKKIFGFESWKG------------------------------
--------------------------------------------------------KLPF
GSLT--------------KWQRN--------SI----------GISPKDGNSTTSWNRYH
IQDKDLRK-----IHR---------------AASAGNA----------------------
QE---MEEILLTSL-RH--LN-DRDRK------------------NRTAL----------
----------HLAC--ANGHPKVVALLADSKCQLNL--CDNENKTALIK-----------
-AVQCQEEECATILL-ERGADPNIMDIY----GN--TALHYAV-AGQNMDIATKLLSYKA
NIEARNKN-E---LTPLL------LAVSENKQQMVE-FLVKRNAN--------VHAV---
-DKVKS-------NC-KLTSEN--KEER--RCKDSQN-SN--------------------
--PE-TSI-KITHLAER----TAA------E-----------------------------
------------------------------------------------------------
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-----------------------------

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------------------------------------------------------------
-------------------------------------MLQEEIARLRLEIDALKNWNQQK
EKNFLEDIKILKEKNDFLQNALMLKEETFA--------TMIFQDSIQPEIL-KA------
ENEMPSFK-----------------------------------LKDKSQNQ---------
--ERLEREIESYRCRLAAALQDR--DQSQASKRDVE----CDFQRTREEWFHLKEKMNFD
MSDLKGKNELLS--------------------------E-KLSNAENKIRS--LKMKWHQ
TK-DALREKTLV-LED--VQRDL--TQSQCRRKE-----IEQMFQN-EEDKV------SK
YIQKQESLEERLSQIQNENLLLRQQLDEAYKKA---DNQEETIINIQE----QFNAIVKN
-QAQS-EEQSLLLEQKNNNLINKC-DFIKKRLYKYEKEKAERNV--SIEKEN--------
------------------------------------IFQTS-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

MGA-----EVSSKPAASTMKKPFGLSGK--------------------------------
------------------------------------------------------------
-------------------MGKW-CCHCFPSCRGSGKNHVDSRGDHDD---IAYL-----
------GK-----LHR---------------AAWWGKV----------------------
PR---ADQSKDKRG-PY--L------GK------------------RTAL----------
----------HLAC----GNSEVGKLLLDRKCQLRV--FDSKKRTALTQ-----------
-AVRC-----AILLL-QHDIDPNLPDLY----GN--TALHYAV-YSEDRLMAKTLLLYNA
DIESKNKG-G---LTPLL------LGVHGQKQQMVE-FLIKKKAN--------LNAL---
-DRFGR-------TA-LILAVR--CGS-A-SMVSL-------------------------
--LL-QQN-IDV--------FSQD------VSR-WTAED---YA-IS---SHH---NI--
--ICQLLSDYKEKQMPKKCSEN--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------SNPEQ-----------
---------DLKLTSEE------------------EPQ------------RLK-------
--------------------------------GGENR-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------QHE--------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------KMSQEPDVNK-----------
---DCDREAE--------------------------------------------------
---------EEMQRHG--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----SNN------------------------------VGIS------------------
------------------------------------------------------------
-----------------------------------------V-------NL---------
--------------------------------------------------TDG-------
------------------------------------AAA---------------------
---G---------NG---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------D-DGLI---------------------------P----
----Q-------------------------------------------------RKSRKP
----------------------------------------ENQ-----------------
--QFPSTE------------------------------------------------NE--
------------------E-----------------------------------------
----------------------------------------------------YH------
-RPEKKFNEKN-------------------------------------------------
------------------------------------------------------------
-----------------------------K------------------------------
-------VKSEIQSV---------------------------------------------
------------------------------------------------------------
-------------------------------DDL---DD---ITWPSEIASEDY------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------DL
------------LY---PNYETFMSLAEQLK---MD--FNG--STSLSKIQDA----VLS
DEYLLEL---KNNH-------------------REQLTVEIEKMENM-------------
--IHVLQ----KKLSEAK---ETQLQLEHEKDE-WEQEL--SALR---------------
------------------------------------------------------------
------------YDILVLKNILTIYAKDTCEN-------------------YCDC-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------VERLSAAAVKG-----E-------------------------
--------------------------------------------------------TGPE
RPSP--------------FSQL-----------------------------VYTNNDSYV
IHHGDLRK-----IHK---------------AASRGQA----------------------
WK---LERMMK-KTTMD--LN-IRDAK------------------KRTAL----------
----------HWAC--ANGHAEVVTLLVDRKCQTDI--L---------D-----------
-ALQYQREACANILI-DSAADPNIVDVY----GN--TAVHYAV-YSENLSV----LSCGA
DIEVKNKA-G---HTPLL------LAIRKRSDQIVE-FLLTKNSN--------ANANADA
LDKFKW-------Y----------------------------------------------
------------------------------------------------------------
---S--NLKFVDKIHK-N-QQDT-----FKVLL---------------------------
--------KKETKDIWDNILDSSA------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
-----------------------------

------------------MKKIFNFGNKKG------------------------------
--------------------------------------------------------QSPS
CSFA--------------TPPRDCG------------------------ARASDPNAGYL
IRDKDLGK-----LHK---------------AAWIGDV----------------------
AK---VQKLLLLRK-HN--VN-DVDKV------------------KRTPL----------
----------HLAC--ANGYPDVVSLLVERKCKLNL--CDNDRRTPLIK-----------
-AVQCQQEECATILL-EHGADANLVDSN----NN--TALHYAA-SGLNKAIATKLLKHQT
DIEAKNKE-G---YTPLL------LAITENNPDMVD-FFLKNGAN--------VNAT---
-DKSKR-------TA-LMIAVS--SEPT--IIVSL-------------------------
--LL-QYEALDL--------SCQD------IYG-WTAKE---YA-IV---SGY---PI--
--HSQLISQ---YEIRKEHNQHF-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------S--------------
------------------------------------------------------------
------------------------------------------------------------
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-----------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------NVQGYF
IRYKDLGK-----LHK---------------AASIGDL----------------------
EK---VHHLLS-K-KHD--VD-KRDKE------------------HRXXXXXXXXXXXXX
XXXXXXXTSSHLAC--TMGYPDVASHLVER-KKLNI---YSENRSPLIK-----------
-KVQCQHEEYATILL-ENKEKPNFKDIN----KN--TALHNAA-PGHNISLVNK--KHKT
NIEAQRXD-G---HTPLL------LAITENNPEMVA-ILLKKGAD--------VNAS---
-DKLQ-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
-----------------------------

MVA-----EVCSMPTASAAKKPFDLRSKMG------------------------------
--------------------------------------------KWCCHCFPCCRGSGKS
NVGASGDQGNSAVKTLRSKMAKW-CCHCFPCCRGSGKSNVGAWGVYDD---SAFMEPRYH
VRQEDLDK-----LHR---------------AAWWGKV----------------------
PR---KDLIVMLRD-TD--MN-KRDKQK------------------RTAL----------
----------HLAS--ANGNSEVVKLLLDRQCQLNV--LDNKKRTVLIK-----------
-AIQCQEDECALMLL-EHGTDPNIPDEY----GN--TALHYAI-YNEDKLMAKALLLYGA
DIESKNK-------------------------RVVK-FLIKKKAN--------LSAL---
-DRYGR-------TA-LTLVVC--CGS-A-SIVSL-------------------------
--LP-AQN-IDV--------SSQD------LSG-QTARE---YA-VS---SHH---NV--
--ICELLSDYKEKQMLKISSEN--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------SNPEQ-----------
---------DLKRTSEE------------------ESQ------------RLK-------
--------------------------------VSENS-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------QPE--------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------KMSQEPEINK-----------
---DCDRVVE--------------------------------------------------
---------EEIKKHG--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----SNP------------------------------VGLP------------------
------------------------------------------------------------
-----------------------------------------E-------NL---------
--------------------------------------------------TNG-------
------------------------------------ASG---------------------
---H---------LQ---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------YFM------------------------------------
------------------------------------------------------------
-----------------------------------KIKI--F-SN---------------
------------------------------------------------------------
------------DEQNDTQKQLSEEQNTGISQDEIL-----TN---K--QKQTEVAE---
-KKMNSELSLS-----HNEEKD---LLHE------NSMLQEEIAMLRLELDEIKHQHQLR
ENKFWEEIESVKEKNDKLLKAVKLNKEALR--------KIN-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

MGA-----EVSPKPSASPMKKPFGLRST--------------------------------
------------------------------------------------------------
-------------------MGKW-CCHCFPCCWGSGKNNVGAWGDHDD---SAFREPRYH
VRREDLGK-----LHR---------------AAWRGKV----------------------
PR---ADLIIMLRG-PG--VN-KRDKKK------------------RTAL----------
----------HLAC--ASGNPEVVKLLLDRQCDLHV--FDSKKRTALIK-----------
-AIQCQEDESALMLL-EHGTDPNIPDVY----GN--TTLHYAV-YNEDKLMAKTLLLYGA
DIDSANKS-G---LTPLL------LGVHGQKEQMVK-FLVKKKAN--------LNAL---
-DRFGR-------TA-LILAVC--RGS-A-SIVSI-------------------------
--LL-QQS-IDV--------FSRD------ASG-RTAED---YA-VS---SRH---DI--
--ICQLLSDYKEKQMSKSSSQN--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------SNPEQ-----------
---------DLKMTSEE------------------EPQ------------RLK-------
--------------------------------GSENS-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------QPE--------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------KMSQEPDINK-----------
---DCDREAE--------------------------------------------------
---------EEMQKHG--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----SNN------------------------------VGLS------------------
------------------------------------------------------------
-----------------------------------------E-------NL---------
--------------------------------------------------TNG-------
------------------------------------VAP---------------------
---G---------NG---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------G-YGLI---------------------------Q----
----R-------------------------------------------------RRSSKP
----------------------------------------ENQ-----------------
--QFSSTE------------------------------------------------NE--
------------------E-----------------------------------------
----------------------------------------------------YH------
-KPEEKSNENN-------------------------------------------------
------------------------------------------------------------
-----------------------------K------------------------------
-------VKSPIHSV---------------------------------------------
------------------------------------------------------------
-------------------------------DDL---DD---ISWPSEVASEDY------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------DW
------------LY---SNYVTYMLLNEELD---MD--FND--FASLSKIQDA----VLS
DEHLLEL---QNNH-------------------WEQLTVEIEQMENM-------------
--IDVLE----KELSEAK---ETKLQLQHQKGE-FEQEL--STLR---------------
------------------------------------------------------------
------------YDTVF-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TPL----------
----------HLAC--ANGRSSVMPQLIDKKCKKNA--REREKISPITE-----------
-TVQCKKEICAAILL-HYGADPNLMDLN----GN--TALHYAV-CGEKTSLVEKLLEYKA
NLEIQNKD-G---YTPLL------LAITENNAKMVE-FLLKRGAN--------VNAS---
-DKNQR-------TA-LMIALI--YEPE--TLVSL-------------------------
--LL-KQD-VDL--------SCQD------I-G-FTAEE---YA-SF---NGL---S---
------------------------------------------------------------
------------------------------------------------------------
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-----------------------------

------------------------------------------------------------
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------------------------NALILAVRCGSASIVSLLLEQNIDVSSKDLSGQTAR
DYAVSSHHNV-IC-QLLSDYEEKQMLKISSENSNPEQDLK---LTSEEESQR--------
-----------------------------------------------------------L
KGSE-------------NSQP---EEMSQEPEINKD--CD--------------------
--REAE--------------------------------EDMK----KHGSNNMGLPENLT
NDAAA-------------------------------------------------GNGDDG
LI-------------PQ---------------------SKSRTPESQQFPD---------
----TENEEYHSDEQNDTQKQVSEEQNAGISQEEILT-----G-----KQEQME------
--VAEKKMNSE-VSLTNKKEKD---LLHE------NRMLQEEIAMLRLEVDKIKQQSQLR
EKKLLEEIESVKAKNEKLLKAVKLSEETLTKISI--------------------------
------------------------------------------------------------
------------------------------------------------------------
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-----------------------------

------------MEVRGSFLA---------------------------------------
------------------------------------------------------------
------------------ACRRRMATWRKNR----------------D--KDGFSNPGYR
VRQKDLGM-----IHK---------------AAIAGDV----------------------
NK---VMESILLRL-ND--LN-DRDKK------------------NRTAL----------
----------LLAC--AHGRPGVVADLVARKCQLNL--TDSENRTALIK-----------
-AVQCQEEVCASILL-EHGANPNVRDMY----GN--TALHYAI-DNENISMARKLLAYGA
DIEARSQD-G---HTSLL------LAVNRKKEQMVA-FLLKKKPD--------LTAI---
-DNFGR-------TAL-ILAAR--NGS-------------------TS----------VV
YQLL-QHN-IDV--------FCQD------ISG-WTAED---YA-VA---SKF---Q---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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----------------------------------------AIRG--------------MI
SEYK--------------------------------------------------------
------------------------------------------------------------
-----ANK-------------------------------RC-------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
---------------------------------------------K---S----LQNSNS
EQDLEMTSEGEQERLEG-------------CESSQPQVE--------EKMKKCR------
---------------------------NKKMEVS---RNVHADDSDNY------------
---NDDVDELIH---------KIKNRKPD----NHQSPGKENGEF---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------DRLARKTSNEKSK---VKSQIYFTD--------
------------------------------------------------------DL-NDI
SGSSEKTSEDDELP--YSDDENFMLLIEQSG---ME--CKD--FVSLSKSKNA----TAA
CGRSIED---QKCY-------------------CERLKVKFQKMKNN-------------
--ISVLQ----KVLSETD---KTKSQSEHQNLQ-GKKKL--CNLRFILQQQEEERIKAEE
LY-EKDIEE----LKIMEEQ------------------YRTQTEVKKQSKLTLKSLEVEL
KTVRSNSN-QNF------------------------------------------------
--------------HTHERERD---LWQE------NHLMRDEIARLRLEIDTIKHQNQET
ENKYFKDIEIIKENNEDLEKTLKRNEEALT--------KTITRYSKELNVL-M------D
ENTMLNSE-----------------------------------LQKEKQSM---------
--SRLETEMESYRCRLAAALCDH--DQRQSSKRDLQ----LAFQSTVNEWCHLQEDTNSH
I-------QILS--------------------------Q-QLSKAESTSSG--LETELHY
ER-EALKEKTLH-IEH--MQGVL--SRTQRRLED-----IEHMYQN-DQPIL------EK
YVRKQQSVEDGLFQLQSQNLLYQQQCNDARKKA---DNQEKTIINIQV----KCEDTVEK
LQAEC-RK----LEENNKGLMKEC-TLLKERQCQYEKEKEEREV--VRRQLQREVDDA--
--LNKQ------LLLEAMLEISSERRINLEDEAQSLKKKLGQMRSQ-VCMKLSMSTVTL-
------------------------------------------------------------
------------------------------------------------------------
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-----------------------------

MVA-----EVSSIPAASTVKKPFGLRSKMGKWC---------------------------
----------HHCFPCCRGRGKSNVGASGDQDDSVMEALGSKMAKWCCHCFPCCRGSGES
NVGPSGDQEDSAMKTHRSKIAKW-CCHCFPRCKGRGESNVEAWEDYDD---SAFMEPRYH
VRGEDLDK-----LHR---------------AAWWGKV----------------------
PR---KDLILMLRD-TD--VN-KTDKQK------------------RTAL----------
----------HLAS--ANGNSEIVKLLLDRGCQLNV--LDNKKRTALIK-----------
-AVQCQEDECALMLL-EHGTAPNIPDEY----GN--TALHYAI-YNEDKLMVKALFLYGA
DIESKNKH-G---LTPLL------LGVHGQKQQVVK-FLIKKKAN--------LNAR---
-DRCGR-------TA-LILAVC--CES-A-SIVSL-------------------------
--LL-EQN-IDI--------SSKD------LSG-QTA-R---YA-VS---SHH---NV--
--ICQLLSDYKEKQMLTISSEN--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------SNPEQ-----------
---------DLKLTSEE------------------ESQ------------RLK-------
--------------------------------GSENS-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------QPE--------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------EISQEREINK-----------
---DCDREVE--------------------------------------------------
---------EEMKKHG--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----SNH------------------------------VRLP------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
----------------------------------ENLTNDAAAGNGD-------------
--DGLIP----QSKSRTP---ESQ-----QFPD-TENEE--Y-HS---------------
------------------------------------------------------------
------------DEQNDTQKQVSEEQIVGMSQEEIL-----TN---K--QEQMEVAE---
-KKMNSEVSLS-----HKKEKD---LLHE------NRMLQEEIAMLRLEVDKIKQQSQLR
EKKLLEEIESVKAKNDKLLKAVKLREETIT--------KINI------------------
------------------------------------------------------------
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-----------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------M------------------VPEGY----------
----------FVTKHQSYALNYIYFFIVDLKCVLLF--S---------------------
------------LI------------VD-ES-SE------DS--LS-SL-FF-FF-----
-----ETE-----SR-SV---------AQ-AG-VQ--WC-DF-GS---------------
--------------L-Q-APP-----PG-----FM-------------------------
----------PF--------SCLS------LP----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------SSWDYRLSG--KPGV------------------DD--SWPTSDDED-------
----------LNFDTKN-----VPK--------------PSLAKLMTA------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------S--QQSRKNLE---ATYGIVRT
GSRTLFEDRD----------SDSQDEVVVESLPTTSVKAQGFSHPT--CQSPDP-LPKPS
HKSL--------------------------------------------------------
------------------------------------------------------------
--------------------------------ANPGLIKEGPTKPAVEKKE---------
---NGIDIIE----SAPLEQT--------------NSDNLT-------------YVDEVH
KNN----RSDMMSALGLGQEEDIESPWDSESI-SENFPQKYVD--P-------------L
AGAA--------------------------------------------------YQ----
------------------------------------------------------------
-------------------------------------------KE-----KNIGNEQA--
E-----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------ES---------------------------
----PERY----------------------------------------------------
------------------------------------------------------------
------LHLKPAIEMK------DSVPNKAG------------------------------
--------GMK-------------------------------------------------
------------------------------------------------------------
----DVQT-------------SKA------------AERD-LEVA-SEE-----------
----------------------------------EQ-ER-E---E-S-------------
--------------------------------------ENNQPQVEEERKKH---RNSKM
EVSA-----------NIHDGATDN------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------D-EDNGL-IQER----------
--RSGE------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------TDHQQFPRKENKEY---------------
-------AS--SGPALQMKA-VKR--------TSKESVNSPVF-----------EK----
----------------------AGLLTGGLL-----------------------------
-----------------------------------QV--DDDS----S------------
------------------------------------------------------------
----------------LSEIDEDE---ERPSKKTSNEKNK---VKNQIQSMD--------
------------------------------------------------------DV-DDL
TQSSETASEDCELP--RSSYKNFMLLIEQLG---ME--CK--DSVSLLKIQDA----ALS
CERLLEL---KKNH-------------------CELLTVKIKKMEDK-------------
--VNVLQ----KELSETK---EIKSQLEHQKVE-WEREL--CSLRFSLNQEEEKRRNADM
LY-EKIREQ----LRRKEEQ------------------YRKEVEVKQQLELSLQTLEMEL
RTVKSNLN-QVIQERNDTQRQLSREQNARMLQDGIL-----TSHLSK--QKEIE------
--MTQRKMNSE-TSHSHEEEKD---LLHK------NSMLQEEIAMLRLEIDTIKNQNQEK
EKKCFEDLEIVKEKNEDLQKTIKQNEETLT--------QTISQYNGRLSVL-TA------
ENTMLNSK-----------------------------------LESEKQSK---------
--ERLEAEVESYRSRLAAAIHDR--DQSETSKRDLE----LAFQRARDEWSRLQDKMNFD
ASHLKDNNEILS--------------------------Q-QLFKTESKLNS--LEIELHH
TR-DTLREKTLG-LER--VQKDL--SQTQCQMKE-----MEQKYQN-EQVKV------NK
YIGKQESVEERLSQLQSENMLLRQQLDDAHNKA---DNKEKTVINIQD----QFHAIVQK
LQAES-EKQSLLLEERNKELISEC-NHLKERQYQYENEKAER EV--VVRQLQQELADT--
--LKKQ------SMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQ-LQEAQDRHTEAVR
CAEK-----------------------------------MQDHKQKLEKDNAKLKVTIKK
QMDKIEELQ----KNLLNANLSE-------------------------------------
-------------------------------DE---KE-QLKKL---MELKQSLECN-LD
QEMKKNVELEREITGFKN-----LLKMTR--------------KKLNE------YENGE-
---L-SFHGDLKSSQFEMDIQINKLKHKIDDLTADLETAGSKCLHLDTK-----------
-NQVL--QQELLSMKTIQKKCEKLQKNKKKLEQEVVNLRSH---IER-NMVELGQVKQY-
KQEIEERARQEI-VEKLKEVNL---FLQAQAA-SQENLEQ-LREN-NFASM KSQMELRIK
DLESEL-SKIKTSQEDF------NKTELEKYK----QLYLDELKVRKSLS-NKLNKTNER
LAEVSTKLLVEKQQ---SRSLFT------TLTTRPVMEPPCVGNLNNSLDHNRKLIPREN
LVI-SSSNPRTSNNS-VENYLSKMQQELEKNITRELEEA-AAE-----LES-----G---
--------------------SI-ASPLGST---------DES----NLNQDLVWKASREY
VQVLKKN--YMI------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------------------------------------------------
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------------------------------------------------------------
-------------------------------------------------ALLWSQLLRRL
GQ------------EDCLSLRISGYI---------------------------------A
LQFPEISSYSPRT--V--LHLACAHG--R------V----EVVTL-LLSR----------
--SCQI------------------------------------------------------
-----------------------------------------------------DICDRLN
R-----------------------------------------------------------
-----------------T--------PLMKVYSSQLFQVKINLSH---------------
-------LNITKACAIILLE-HGANPNI-----------KDIY-----------------
------------------------------------------------------------
--------GNTALHYAVYNK--GTS--LAEKLLS--------------------------
--------------------------HHANIEALN------------------EL-----
----AC---------------------------LAET-----------------------
------------------------------------------------------------
--AAVK-------P--AN-----LE-KR------KE--GAKAEHNLKV-------ASEEK
QERLERS---GNKQ------------------------PQDS------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------QSYGRKKD---VMYG------NYMLKRDIAMLKQELYTIKNDSLRK
EKEYIQEIKSITEMNANFEKSVRLNDEMIT--------KTTAQYSQQLNEL-KA------
ENTRMNSK-----------------------------------LEKEKHSK---------
--ERLEVEVESLHSSLATAINEY--NEIL-ERKDLE----LVLWRADDV--SVHEKMDSN
ISQLTDKNELLT--------------------------K-QLSKARVKFNT--LKGKLHE
TR-DALREKTLA-LES--VQMDL--KQAQYRLKE-----MKQMHPN-EEAKE------SQ
SFGKQNSLEERIHQ-ELENLLLEQQLKDAYKEG----NNKEIVINIQE----DC------
--LEN-GKEDL-TEEKNMELMNEY-NYLKEKLFQYEKEEAEG EV--IVRRLQEELADH--
--LNKF------SMSESPLEGTSHCHINLDD-TQASKKKLFQVGSQ-PEEKHEEFRKLFE
LRSS--------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------LDYNVDQ
IRK-KNHKLEEETTGYKK-------------------CLEMTINMLNV------FGNED-
---F-SCHGDLNTDQLKMDILFKKLKQKFDDLTAEKEAVSSKCVNLAKD-----------
-NQVL--QQEFLSMRKIQEKCEKLEEDKKMLEEEVLTLKTH---MEN-NMVELGKVQEY-
KLELDERTMQII--EKLEETHL-----QEQAK-YEKQLEQ-LNK--DNIASL NKKELTLT
DVECKF-SEMKTAYEEV-------TTELAEYK----EAFAVALKANNSMS-KNLMKSNKK
IAVISTKLLMEKER---MKYFLS------TLPIRPDPELPCIENLNS-IGLNRKDISKTP
IRI-PTSNPQTSNNC--ENSLT------------EVSY----------------------
---------------------MTISLLGFISLI---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------MKKIF---SKKG------------------------------
--------------------------------------------------------ESPL
GSFA----------------RRRRSSAGGGG----------------ELGEGAYSQPGYH
VRDRDLGK-----IHK---------------AASAGNV----------------------
AK---VQQILLLRK-NG--LN-DRDKM------------------NRTAL----------
----------HLAC--ANGHPEVVTLLVDRKCQLNV--CDNENRTALMK-----------
-AVQCQEEECATILL-EHGADPNLADVH----GN--TALHYAI-YNEDIPVATKLLLYDA
NIEAKNKD-D---LTPLL------VAVNGKKQQMVE-FLIKKKAN--------VNAV---
-DKLES-------SH-QLIPEY--KEER--IPKNSSQNSNSVDESSED------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------SLSRLSG--KPGV--------------D----D--SWPTSDD---------
--------EDLNFDTKN-------------------VPKPSLAKLMTASQQSRK---NLE
ATYGIVRT------------------GSRTLFEDRDSDSQ--------------------
---------------------D-------------------EVVV---------------
------------------------------------------------------------
-----------------------------ESLPT--------------------------
----------------------------------TSVKAQGFSHPT--CQSPDPLP-KPS
HKS---------------------------------------------------------
----------------------------------------LANP----------------
-----------------------------------GLIKEGPTKPAVGKKE---------
---NGIDIIE----SAPLE--------------QTNSDN-------------LTYVDEVH
KNN----RSDMMSALGLGQEEDIESPWDSESI-SENFPQKYVD---------------PL
AGAAYQKEKNIGNE---Q------AED----------------------------MFYIP
SCMSGSRNFKMAKLEDTRNV--------------GMPVAHMESPERYLHLKPA----IEM
-KDSVPNK-----------------------------EGGMK------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------DV------------------
---------------------------------------------QTSK-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------AA
ERDLEVASEEEQER-EE-------------SENNQPQVE--------EERKKHR------
---------------------------NSEMEVS---ANIHDGATDND------------
-----EDDGLIQ---------ERRSGETD----HQQFPRKENKEY---------------
---------ASSGPALQMKA-VKR--------TSKESVNSPVFEKAGLL-----------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------TGGLLQVDDDSSLSE-
-------------------IDEDEE---RPSKKTSNEKNK---VKNQIQSMD--------
------------------------------------------------------DV-DDL
TQSSETASEDCELP--RSSYKNFMLLIEQLG---ME--CKD--SVSLLKIQDA----ALS
CERLLEL---KKNH-------------------CELLTVKIKKMEDK-------------
--VNILQ----KELSETK---EIKSQLEHQKVE-WEREL--CSLRFSLNQEEEKRRNADM
LY-EKIREQ----LRRKEEQ------------------YRKEVEVKQQLELSLQTLEMEL
RTVKSNLN-QVIQERNDTQRQLCREQNARMLQDGIL-----TSHLSK--QKEIEMTQ---
-RKMNSETSH-----SHEEEKD---LLHK------NSMLQEEIAMLRLEIDTIKNQNQEK
EKKCFEDLEIVKEKNEDLQKTIKQNEETLT--------QTISQYNGRLSVL-T------A
ENTMLNSK-----------------------------------LESEKQSK---------
--ERLEAEVESYRSRLAAAIHDR--DQSETSKRDLE----LAFQRARDEWSRLQDKMNFD
ASHLKDNNEILS--------------------------Q-QLFKTESKLNS--LEIELHH
TR-DTLREKTLG-LER--VQKDL--SQTQCQMKE-----MEQKYQN-EQVKV------NK
YIGKQESVEERLSQLQSENMLLRQQLDDAHNKA---DNKEKTVINIQD----QFHAIVQK
LQAES-EKQSLLLEERNKELISEC-NHLKERQYQYENEKAER EV--VVRQLQQELADT--
--LKKQ------SMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQ-LQEAQDRHTEAVR
C-----------------------------------AEKMQDHKQKLEKDNAKLKVTIKK
QMDKIEELQ----KNLLNA-----------------------------------------
------------------------------NLSEDEKE-QLKKL---MELKQSLECN-LD
QEMKKNVELEREITGFKNL-----LKMTR--------------KKLNE------YENG--
--EL-SFHGDLKSSQFEMDIQINKLKHKIDDLTADLETAGSKCLHLDTK-----------
-NQVL--QQELLSMKTIQKKCEKLQKNKKKLEQEVVNLRSH---IER-NMVELGQVKQY-
KQEIEERARQEI-VEKLKEVNL---FLQAQAA-SQENLEQ-LREN-NFASM KSQMELRIK
DLESEL-SKIKTSQE------DFNKTELEKYK----QLYLDELKVRKSLS-NKLNKTNER
LAEVSTKLLVEKQQ---SRSLFT------TLTTRPVMEPPCVGNLNNSLDHNRKLIPREN
LVI-SSSNPRTSNNS-VENYLSKMQQELEKNITRELEEA-AAE-----LES-----G---
--------------------S-IASPLGST---------DES----NLNQDLVWKASREY
VQVLKKN--YMI------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TVL----------
----------HLAC--AHGRVEVVTLLLSRSCQIDI--CDRLNRTPLMK-----------
-AVHCQEEACAIILL-EHGANPNIKDIY----GN--TALHYAM-YNKGTSLAEKLLSHRA
NIEALNEE-G---NTPLL------FAINSRRQQMVE-FLLKNQAN--------IHAV---
-DNFRR-------TA-LMLAVQ--HSSS--SIVSL-------------------------
--LL-QQN-INI--------FSQD------MFG-QTAED---YA-VC---CDL---RS--
--IQQQIL---E------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------H--------------
------------------------------------------------------------
-------------K-----------------------------NK-------I-------
-----------------------------LK----------NHLR---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------N----------------------------------------------------
------------DNQETAA-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------VK-------------------------------------------PA-------
------------------------------------------------------------
-------------------------------------------------NL--K------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------K
------------------------------------------------------------
----------------------------RK-------EGAKA------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------EHNLKVASEEKQERLER--SGNKQPQDS---------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------QSYGRKKD---VMYG------NYMLKRDIAMLKQELYTIKNDSLRK
EKEYIQEIKSITEMNANFEKSVRLNDEMIT--------KTTAQYSQQLNEL-K------A
ENTRLNSK-----------------------------------LEKEKHSK---------
--ERLEAEVESLHSSLATAINEY--NEILER-KDLE----LVLWRADDVSV--HEKMDSN
ISQLTDKNELLT--------------------------K-QLSKARVKFNT--LKGKLHE
TR-DALREKTLA-LES--VQMDL--KQAQYRLKE-----MKQMHPN-EEAKE------SQ
SFGKQNSLEERIHQQELENLLLEQQ-LKDVYKE---GNNKEIVINIQE----DCL-----
---EN-GKEDLT-EEKNTELMNEY-NYLKEKLFQYEKEEAEG EV--IVRRLQEELTDH--
--LNKF------SMSESPLEGTSHCHINLDD-TRASKKKLFQVGSQ-PEEKHEEFR----
------------------------------------------------------------
-------------K----------------------------------------------
-------------------------------------------L---FELISSLDYN-GD
QIRKRNHELEEETTGYKKC-----LEMTI--------------NMLNV------FGNE--
--DF-SCHGDLNTDQLKMDILFKKLKQKFDDLTAEKEAVSSKCVNLAKD-----------
-NQVL--QQEFLSMRKIQEKCEKLEEDKKMLEEEVLTLKTH---MEN-NMVELGKAQEY-
KSELDEKTMQII-EKLEEI------HLQEQAK-YEKQLEQ-LNKD-NTASL-NK KKLTLT
DVECKF-SEMKTAYEE-----V--TTELEEYK----EAFAVAFKANNSMS-KNLMLLLCW
AL-----------A---PIYFLL-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------MKKIF---SKKG------------------------------
--------------------------------------------------------ESPL
GSFA----------------RRRRSSAGGGG----------------EPGEGAYSQPGYH
VRDRDLGK-----IHK---------------AASAGNV----------------------
AK---VQQILLLRK-NG--LN-DRDKM------------------NRTAL----------
----------HLAC--ANGHPEVVTLLVDRKCQLNV--CDNENRTALMK-----------
-AVQCQEEKCATILL-EHGADPNLADVH----GN--TALHYAV-YNEDISVATKLLLYDA
NIEAKNKD-D---LTPLL------LAVSGKKQQMVE-FLVKKKAN--------VNAV---
-DKLES-------SH-QLISEY--KEER--IPKHSSQNSNSVDESSED------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------SLSRLSG--KPGV--------------D----D--SWPTSDD---------
--------EDLNFDTKN-------------------VPKPSLAKLMTASQQSRK---NLE
ATYGTVRT------------------GNRTLFEDRDSDSQ--------------------
---------------------D-------------------EVVV---------------
------------------------------------------------------------
-----------------------------ESLPT--------------------------
----------------------------------TSIKVQGFSNPT--YQSPDLLP-KPS
HKS---------------------------------------------------------
----------------------------------------LANP----------------
-----------------------------------GLMKEEPTKPGIGKKE---------
---NGIDIIE----SAPLE--------------QTNNDN-------------LTYVDEVH
KNN----RSDMMSALGLGQEEDIESPWDSESI-SENFPQKYVD---------------PL
AGAADGKEKNIGNE---Q------AED----------------------------VFYIP
SFMSGSRNFKMAKLEDTRNV--------------GMPVAHMESPERYLHLKPT----IEM
-KDSVPNK-----------------------------AGGMK------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------DV------------------
---------------------------------------------QTSK-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------AA
EHDLEVASEEEQER-EG-------------SENNQPQVE--------EERKKHR------
---------------------------NNEMEVS---ANIHDGATDDAED----------
DD--DHDDGLIR---------KRKSGETD----RQQFPRKENKEY---------------
---------ASSGPALQMKE-VKRTEK--EKRTSKESVNSPVFGKASLL-----------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------TGGLLQVDDDSSLSE-
-------------------TDEDEG---RPTKKTSNEKNK---VKNQIQSMD--------
------------------------------------------------------DV-DDL
TQSSETASEDCELP--HSSYKNFMLLIEQLG---ME--CKD--SVSLLKIQDA----ALS
CERLLEL---KKNH-------------------CELLTVKIKKMEDK-------------
--VNVLQ----RELSETK---EIKSQLEHQKVE-WEREL--CSLRFSLNQEEEKRRNADM
LY-EKIREQ----LRRKEEQ------------------YRKEVEVKQQLELSLQTLEMEL
RTVKSNLN-QVVQERNDAQRQLSREQNARMLQDGIL-----TNHLSK--QKEIEMAQ---
-KKMNSENSH-----SHEEEKD---LSHK------NSMLQEEIAMLRLEIDTIKNQNQEK
EKKCFEDLKIVKEKNEDLQKTIKQNEETLT--------QTISQYNGRLSVL-T------A
ENAMLNSK-----------------------------------LENEKQSK---------
--ERLEAEVESYHSRLAAAIHDR--DQSETSKRELE----LAFQRARDECSRLQDKMNFD
VSNLKDNNEILS--------------------------Q-QLFKTESKLNS--LEIEFHH
TR-DALREKTLC-LER--VQKDL--SQTQCQMKE-----MEQKYQN-EQVKV------NK
YIGKQESVEERLSQLQSENMLLRQQLDDAHNKA---DNKEKTVINIQD----QFHAIVQK
LQAES-EKQSLLLEERNKELISEC-NHLKERQYQYENEKAER EV--VVRQLQQELADT--
--LKKQ------SMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQ-LQEAQDRHTEAVR
C-----------------------------------AEKMQDHKQKLEKDNAKLKVTIKK
QMDKIEELQ----KNLLNA-----------------------------------------
------------------------------NLSEDEKE-QLKKL---MELKQSLECN-LD
QEMKKNVELEREITGFKNL-----LKMTR--------------KKLNE------YENG--
--EF-SFHGDLKTSQFEMDIQINKLKHKIDDLTAELETAGSKCLHLDTK-----------
-NQIL--QEELLSMKTVQKKCEKLQKNKKKLEQEVINLRSH---IER-NMVELGQVKQY-
KQEIEERARQEI-AEKLKEVNL---FLQAQAA-SQENLEQ-LREN-NFASM KSQMELRIK
DLESEL-SKIKTSQE------DFNKTELEKYK----QLYLEELKVRKSLS-SKLTKTNER
LAEVNTKLLVEKQQ---SRSLFT------TLNTRPVMEPPCVGNLNNSLDLNRKLIPREN
LVM-STSNPRASNNS-MENYLSKMQQELEKNITRELKEA-AAE-----LES-----G---
--------------------S-IASPLGST---------DDS----NLNQDLVWKASREY
VQVLKKN--YMI------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

--------------------SSFLHTV---------------------------------
------------------------------------------------------------
--------------------WKA--------VV----------GATDEVPARAYSQPWYT
IDEVDFWP-----LHK---------------AACLGNL----------------------
RE---IEIILSQEP-YL--LD-IKDSA------------------YRTAL----------
----------HLAC--ANGHVDVVRLLIEKKCTLDR--HDSKQRTPLLK-----------
-AVQCQEEECATLLL-EVGADPNSRDLY----GN--TALHYAA-YHQNLSLAEKLLAHSA
CIDAKNRS-H---HTPLL------LAVRNNKEKMVE-FLLKNGAN--------KDEV---
-DKSKR------------------------------------------------------
------------------------------------------------------------
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-----------------------------

------------------MERLSAAAVKGQ------------------------------
--------------------------------------------------------MGLE
CPSP-------------------------------------------FSQLVYTNNDSYV
IHHGDLRK-----IHK---------------AVSQGQA----------------------
WK---LERM-MKKTTMDLN---IRDAK------------------KRTAL----------
----------HWAC--ANGHAEVVTLLVDRKCQLDI--LDGKNRTPLMK-----------
-AVQCQREVCANILI-DSGADPNIVDVY----GN--TAVHYAL-YGENLSVVAKLLSCGA
DIEVKNKA-G---HTPLL------LAIRKRSEQIVE-FLLTKNEN--------ANAV---
-DKFKC-------I----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------D-------------------------QQLLKYKQ--------
-----------K------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--ISKNSQ-------------------------------------------NS-------
------------------------------------------------------------
-------------------------------------------------NP---EGTSEG
TPDEA-------------------------------------------------------
-------------APLAER-------------------------------------T-HL
TWL---------------------------------------------------------
------------------------------------------------------------
-------------------KAWWKEHLTN-------------------------------
------------------------------------------------------------
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-----------------------------

------------------------------------------------------------
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-----------------------------------------------TAL----------
----------HYAC--AYGHLAIVALLIE-KCEIDI--CDSDNSTALIK-----------
-ASQCQHEECVTLLL-KYGADPNVRDSS----GN--TAIHYAI-YTNNVPIAAKLLAYNA
SIESQTKD-G---LTPLL------LALKENKQQMAE-FL---------------------
------------------------------------------------------------
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-----------------------------

-----------------MKKRLAKFASWVD------------------------------
--------------------------------------------------------FS--
--------------------------------------------IHRESGNHEKPVPGYH
VHRSELKE-----FHK---------------AAYLGDT----------------------
RT---VQELLSHKK--N--VD-SRDRR------------------NRTAL----------
----------HLAC--ASGQSSVVALLTQWKCDLDA--RDEESRTALIK-----------
-AVQCRKEECVTILL-KQGADPNLEDNF----QN--TALHYAV-LAENTSIAPQLLRYNA
NIEAINQY-N---FTPFL------VAVRENKEEMVK-FLIDNGAN--------VHAV---
-DMLQS-------LY-QQIVDY--RDEK--IPNTPPQNSDL-------------------
------------------------------------------------------------
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-----------------------------

------------------LKLFRPFGSR--------------------------------
--------------------------------------------------------RGHD
GPG---------------------------------------------LYD-CLHGLRIP
IRDPNMQK-----NHR---------------GSCPRAT----------------------
RG---GSGCPGAAQGGD--LD-ALA-A------------------ARTAL----------
----------HLAC--ASGHVKVVTLLVSRKCQIDI--CDKENRTPLIQ-----------
-AVHCQEEACTVILL-EHGTNPNLKDIY----RN--TALHYAV-YSESTSLAEKLLFHGA
NIEALDKD-N---NTPLL------FAIICKKEKMVE-LLLKTKAS--------THAV---
-DRLRQ-------SA-LLLAIH--YDSP--GIVNI-------------------------
--LL-KQN-IDV--------FAKD------ICG-RDAED---YA-IS---HHL---TK--
--N--QLAHFHCVFLL-S----S----ILHELCVD-------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------SLPA-
--------LDDEDLSV--A------------T--------K-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------QCVP-------------E
K-------------VSEPLRGP--------------------------------------
------------------------------------------------------------
-----------------------------------SHEKGNR------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------IVNGKGE-----
------------------------------------GPPAKH-----PSLKPS----TEV
-EDPAVKG-----------------------------SVQ--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------RKDVQTLRAEQ-ALPVASEEEKERC
--------------ERSEKK-QPQ---------------VKEG--NNT---N---ESEKR
QL---------------------------------------------------------S
KKVCHSTSSAA-------------------------------------------------
----------A-------------------------------------------------
------------------------------------------------------------
----------------------------------DRLTKQRK------------------
------------------------------------------------------------
-------------------------------------------IG---------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------KTYPQQFPK------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------KLKE--EHDSCILRQENEEKTNVNM
L------EE----LERKEKQ------------------YKKEVEAKQ-LEPNVQSLEMKP
KTARNTPN-QIN------------------------------------------------
--------QSL-DFHNHEEIKD---LMDE------NCILKTDIAILRQEICTMKNDNLEK
ENKYLKDVKIVKKTNAALENYIKLNEELIT--------KTAFRYQQELNDL-K------A
ENTRLNSE-----------------------------------LLKEEESN---------
--KRLEAEIESYQSRLAAAISKH--SESVKTERNLK----LAL--------------DSD
IPKVEDKNEFLT--------------------------E-QLSKTQIKFNT--LKDKFRK
TR-DTLRKKLLA-LET--VQNYL--SQTQQQIKE-----MKEMYQN-AEAKV------SN
STGKWSSVEDRICQLQYENPCIEQQLDDVHQKK---DHKE-IVTNIQR----VFI-----
---ES-GKTDLMLEEKNKKLMNEC-DHLKESLFQYEREKAERVV--SIKEDKYFQTSR--
--KKI-------------------------------------------------------
------------------------------------------------------------
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-----------------------------

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--MAS---------------WGGEKRGGAEGSPKPAVYATRKTPSV--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------GS---QGDQW-
----------YLGYPGDQWSSGFPYSWWKNSVGSESK--------H-------------G
EGAL--------------------------------------------------DQP---
-----QHDVRLEDLGELHRA--------------ARSGD-------VP-----GVEHILA
PGD-----------------------------------TGVDKRD-RKKSIQQLVPEYKE
KQTPESLPQNNNPDWHPTNLTLSDETCQRSKNLKVDDKCPSVSPSMPENQSATKELGQMN
LTEREKM----------DTG-VVL---------------LSGNDTLH--DLC-QSQLPE-
----------------------NKESK---------------E------AEQDSELTSEE
E---QERLKGCENKQPQ----KTSQEPEMAKDCDRED------------------IPIYP
VLPHVQKSEEMWIEQGKLEWKNQLKL-----------VINELKQRFGE------------
------IYEKYKIP----------------------------------------------
----ACPEEEPLLDNSTRGTDVKDIPFNLTN-N-------------------------IP
GCEEEDASEISVSVVFETFPEQKEPSLKNIIH---------PYYHPYSGSQEHVCQSSSK
FHLHENKLDCDNDNKPGIGHIFSTDKN-FHNDASTKKAR-NPEVVMVEMKE-----D---
QEF-DLQMTKNMNQNSDSG-----------------------------------------
---------------------------STNNYKSLKPKL-E--NL-SSLPPDSDRTSEVY
LHEELQ---QDMQKFKNEVNTLEEEF-----LALKKEDVQLHKDVEEEMEKH---RSNST
ELSG-----------TLTDGTTVG------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------NDDDGL-NQQ-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------IPRKE-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------NGEH-DRPADKTSNEKNE---VKNQIY-----------
---------------------------------------------------PEADF-ADS
MEPSEIASEDCELS--HSVYENFMLLIEQLR---ME--YKD--SASLPRIQDT----FCL
CEHLLKL---KNNH-------------------CDQLTVKLKQMENM-------------
--VSVLQ----NELSETK---KTKLQLELQKIE-WEKEL--YDLRLALKQENEEKRNADM
LY-NKDSEQ----LRIKEEE------------------CGKVVETKQQLKWNLRRLVKEL
RTVRNNLD-LVVQERNDAQKQLSEEQDARILQDQIL-----TS---K--QKELE------
--MARKKMNSE-ISHRHQKEKD---LFHE------DCMLQEEIALLRLEIDTIKNQNKQK
EKKYFEDIEAVKEKNDNLQKIIKLNEETLT--------ETILQYSGQLNNL-TA------
ENKILNSE-----------------------------------LENGKQNQ---------
--ERLEIEMESYRCRLAAAVR--DCDQSQT-ARDLK----LDFQRTRQEWVRLHDKMKVD
MSGLQAKNEILS--------------------------E-KLSNAESKINS--LQIQLHN
TR-DALGRESLI-LER--VQRDL--SQTQCQKKE-----TEQMYQI-EQSKL------KK
YIAKQESVEERLSQLQSENMLLRQQLDDAHKKA---NSQEKTSSTIQD----QFHSAAKN
LQAES-EKQILSLQEKNKELMDEY-NHLKERMDQCEKEKAG RKI----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------DLTEAQETVPSRCLHLDAE-----------
-NEVLQLQQTLFSMKAIQKQCETLQKNKKQLKQEVVNLKSY---MER-NMLERGKAEWH-
KLLIEERARKEI-EEKLNEAIL---TLQKQAAVSHEQLVQ-LRED-NTTSI KTQMELTIK
DLESEI-SRIKTSQADF------NKTELERYK----ELYLEEVKVRESLS-NELSRTNEM
IAEVSTQLTVEKEQTR-SRSLFT------AYATRPVLESPCVGNLNDSEGLNRKHIPRKK
RSA---------LKD-MESYLLKMQQKLQNDLTAEVAGS-SQTGLHRIPQC-----S---
--------------------SFSSSSLHLLLCSICQPFFLILQLLLNMNLDPI-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

MMA-----EVSSIPAASAVKKPFGLRSKMGKWC---------------------------
----------HHCFPCCRGSGKS-------------------------------------
NVGASGDQDDSAMKTLRSKMAKW-CSHCFPCCRGSGES-IVAWEDYDH---SAFMEPRYH
VRGEDLDK-----LHR---------------AAWWGKV----------------------
PR---KDLIVMLRD-TD--VN-KTDKQK------------------RTAL----------
----------HLAS--ANGNSEIVKLLLDRRCQLDV--LDNKKRTALIK-----------
-AVQCQEDECALMLL-EHGTDPNIPDEY----GN--TALHYAI-YNEDKLMAKALLLYGA
DIESKNKH-G---LTPLL------LGIHGQKQQVVK-FLIKKKAN--------LNAR---
-DRCGR-------I----------------------------------------------
------------------------------------------------------------
---CQLLSDCKEKQMLKISSEN--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------SNPGN-----------
---------TCDSELL--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-----------------------------

------------------MKKIFGFRS-KG------------------------------
--------------------------------------------------------PSPL
GPSA----------------RPRSNCVGFGR----------------ESA-SGSHVPRYH
IHDKDMGK-----IHK---------------AASVGDV----------------------
AK---VQHILILGK-SG--VN-DRDKK------------------DRTAL----------
----------HLAC--ASGHPEVVTLLVERKCEIDA--RDSENSTALIK-----------
-AVQCQEEECAAILL-DHGADPNVMDSS----GN--TALHYSV-YSENTSMAAKLLAHNA
NIEAKNKD-D---LTPML------LAVKENKQHIVE-FLVKKKAS--------IHAV---
-DQLGS-------N--KQIFEY--DGKR---LQ-RSENSNPVDNGSED------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------GSLTRSYN--SPGP--------------A----D--SWPTSDE---------
--------EDYNFDNKN-------------------VPKINLTELWTAAQQSRKN----Q
TKCGFEEL------------------DNGARFDDSDSPSE--------------------
---------------------G-------------------EDAI---------------
------------------------------------------------------------
-----------------------------EVEPA--------------------------
----------------------------------PSVRVQTL-SPS--RQSPDP------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------VEGATEPAIEGEE---------
---NGTDVIE----SASQE--------------QPNHDN-------------LTRADGWH
KSN----KSEMMSALGLGEDEDEDSPWDSESI-SESVSLKDVG---------------HF
FGTADQTGKRRAHG---Q------IED----------------------------VTYIP
SCMSGSRSFKMAKLEESRNV--------------GLPVAHMEAPRKYAIMEPT----IER
-RAPVLNKTE---------------------------TVGMK------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------DVQT----------------
--------------------------------------------F---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------KS
EP--ESVSREEQTRLSG-------------SEDSQQKV---------EEKRKYK------
---------------------------SNEAEPS---GNLYSGAADSG------------
------A-DVKP-----------QSGDTD----NQQSRREGSERR-----------G---
-----------SGPALLMKE-AKKMEN--EKWVSREPARTAVSERTGLP-----------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------TGGWPQMQDGSCWSD-
-------------------TDQSEA---RPTKKTSSKHNK---DSGQTAAVD--------
------------------------------------------------------NL-DDF
TESSETASEDHELQ--GPDSESILCAIEHLR---LE--CKD--TASLLKIRDA----VYS
YKRLIEL---KRSH-------------------CELLTGKLRRMENK-------------
--YKGLQ----MEMSETE---DVKSRLEHEKVG-WEQEL--CRLRFALKQEEEKRRSADQ
LS-EKTVEQ----LRRKGAQ------------------CQSEVEARQQLEASLRTLEMEL
KTVKSHLN-QVLEERNETQRQLSREQNARKLQDGIL-----ASHLCK--QKEIEMTQ---
-KKMTSEVSV-----SHEKEKD---LLHK------NQRLQDEVAVLRLEMDTIKSHNQEK
EKRYLEDIKIANEKNDNLQRMVKLNEETFT--------KTIFQYTGQLNSL-K------A
ENTMLSSK-----------------------------------LDNEKQNK---------
--ERLETDVESFRSRLASALHDH--AEIQTAKRDLE----IAFQRARDEWFRVKDKMNFD
MSNLRDNNEVLS--------------------------Q-QLSKTERKLNS--LEIEFHH
TK-DELREKTLA-LKH--AQRDL--SQTQCQMKE-----VEHMFQD-EQGKV------SK
FMGKQESIEERLAQLQSENTLLRQQLDDAANKA---ESKDKTIVNIQD----QFQDVLTR
FQAES-QRHSLRLEDRNQELVSEC-SHLRERLCQYENEKAER EV--VVRQLQQELADT--
--LKKQ------SMSEASLEVSSRYRSNLEEEARDLKKKLGQLRSQ-LQEAQDQHREAVQ
H-----------------------------------AEKMEDHLQKLELEKSKFEITIKK
QSEEIDQLQ----ENLSRV-----------------------------------------
------------------------------NLSEEDKE-KLQKL---TELKESLECT-VD
QEQKRSSALEKELAEFKEV-----LKMTK--------------KELNE------YENR--
--EL-NLRQDIKNNQLEMDIPVSTLIKKIDDLTAKLETASSKCLHLGKK-----------
-NQLL--QQELLLMRTIQKKCGKLEKNKKQLEQEVMNLRSH---MEK-NMVEHSQAQQY-
AREVEERARQDL-VEKLKQVNL---FLQAQAA-SQENLEQ-LREN-SNASV RSQMELRIK
DLESQL-YRMKA-QE------DFDKIELEKYK----QLYQEEFRARKSLS-SKLNKTSEK
LEEASTKLLLEEQQ---NRSLLS------TLSTRPVVECPCVGSLHNSLVFNRTLIPREN
IVV-PTSGLQPSNKR-VEIYLTKMHQELEKSINRELKEA-TAE-----LES-----E---
--------------------FCRVSPLGSA---------TKP------SQDQLSETSQEF
IDILKKK--YMIC-----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------MGVGGSFLGT--------------------------------------
------------------------------------------------------------
-------------------CAGCMAPWRENR----------------G--KDGFSNPGYR
VRQKDLGM-----IHK---------------AAIAGDV----------------------
NK---VQESILLRL-ND--VN-DRDNK------------------NRTAL----------
----------HLAC--AHGHPGVVADLVARKCQLNL--TDSENSTALIK-----------
-AVQCQEEVCASILL-EHGADPNVRDMY----GN--TALHYAI-DNENISMAGKLLAYGA
DIEAKSQD-E---YTSLL------LAINRKKEQMVT-FLLKKKPD--------LTAI---
-DNFGR-------TAL-ILAAC--NGS-------------------TG----------VV
FQLL-QHN-VDV--------CCRD------ISG-WTAED---HA-IA---YNF---Q---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------AIRR--------------LI
SEYK--------------------------------------------------------
------------------------------------------------------------
-----ANK-------------------------------RR-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------K---R----LQNRNP
EQDLKLISEGKQDRLQG-------------CENNQPQVA--------EKMRKCR------
---------------------------NKKMEVS---RYLHADDSDDD------------
-----DDDELIQ---------ERRGRKSD----DHQFPRQKREEY---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------NRLARKTSNEKNK---VKRDLYSKD--------
------------------------------------------------------DL-NDI
IWSPETSSEDDDLP--YSSDKNFMLFIEQHG---ME--HKD--FVSLLKIKNA----ITA
CERSIEH---KKCN-------------------CEQLKVKFQKMKNK-------------
--ISMLQ----KELSETD---ETKSQLEHQNLE-CKQKL--CNFSCILQEEEEKRRKAEE
LY-EKDTEE----LKIMEEQ------------------YRTQTEVKKQLQLTLKSLEVEL
KTVRSNSN-ESS------------------------------------------------
--------------HTHEKERD---LWQE------NHLMRDEIARLRLEIDTIKYQNQET
EKKYFKDIEIIKENNEDLEKTLKLNEETLT--------KTITRYSKELSAL-M------D
ENTVLNLE-----------------------------------LEKEKQST---------
--QRLKTEMESYPCRLAAALHDH--DQCQSAKRDRQ----LAFQSTVNEWCHLQENINSH
I-------QILS--------------------------Q-QLSKVESTSNG--LETELHY
ER-EALKEKTLA-IEH--MQGVL--SRTQCQLKD-----IEHMYQN-DQPIF------EK
YVRKQQSVEDGLFQLQSRNLLYQQQCNDADKKA---DNQEKTIINIRA----KCEDAVEK
LQAEC-RK----LEENNKELMKEC-TLLKERQCQYEKEKEEEEV--VMRQLQREVGDT--
--LNKQ------SLSEAMLEISSQCHHNLEDETRDSKKKLDQLRSQ-VCMKLSMSTVTL-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------MDEN------SN----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------DDSLTRFSS--KPGP------------------DD--SWPTSDDDD-------
----------YLFDNEN-----VPK--------------VNLTELWAA------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------A--QQSRKN-Q---AKYGIGET
GNRTLIDNSP----------SDNKNKDMVETFSKTSVNVQDFSQSS--SSSPSS-E----
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------AKEKATGPVIRKEE---------
---NGAFVIE----NASQEQT---------------HDNVT-------------NVDGGQ
KNY----KSDMMFALGLGEDD--ESPWDSESI-SENLPQKSVD--H-------------L
SGAA--------------------------------------------------DE----
------------------------------------------------------------
-------------------------------------------QG-----KHVGNRQV--
ED---VVYI------PS---CMSGSRNFKMTK------L--E------------------
------------------------------------------------------------
------------------------------------------------------------
----DTGNVGIPV---------------AHKES---------------------------
----PERH----------------------------------------------------
------------------------------------------------------------
------LHLKPATEMK------DPVLNEAV------------------------------
--------GGK-------------------------------------------------
------------------------------------------------------------
----DVQT-------------LKS----EFGKTTLIEEPD-LQVT-SKE-----------
----------------------------------EQ-KR-L--DG-W-------------
--------------------------------------ENNQDQVEEKR-KQ---MSNEM
EVSE-----------NQYDATVANA-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------DNDSDGL-MQQR----------
--KNGE------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------AVSQRFPVKKNEEH---------------
-------DS--SEPVLPLRK-VKKNENE--QWSSTESVTSPVF-----------QP----
----------------------AGSLAGGLL-----------------------------
-----------------------------------QV--KSGC----K------------
------------------------------------------------------------
----------------LHDRDEDE---GRSTKKTSNEKNK---VKKKKNTVD--------
------------------------------------------------------DL-DDL
SQSSETPSEDSELP--YPKYENILLLFEQLR---ME--CK--DSISVLKIWDA----LHS
YKTVIEL---KKDQ-------------------DELLTGKIKKLENK-------------
--LRELQ----KELTETK---EVKSQLEHEKIQ-REREI--GNLRFALKQEEEKRKNVDQ
FY-EKIKEQ----LRKKEEQ------------------YCQEVEAKQQLEVSLRTLDLEL
KTVRKKLN-QVLEEQNDTQRQLSREQNARMLQDRIL-----ANRLCE--QKEIE------
--MTQEKMSPE-VSVSHE--ED---LLHK------NHRLQEELAMIRLEIDAIKNLNQEK
EKKYLEDIEIANKKNDDLQRTIKVNEETFT--------KTIFQYNGQLNIL-TV------
ENTMLNSK-----------------------------------LENEKQNR---------
--ERLETEIESYRSRLAAAVHDY--DESQTSKRELE----LAFQRARDEWFRLQDKMNSD
ISNLKDNNDILS--------------------------H-QLSKVEKKFNS--LEIELHH
TR-DALREKTSG-LEQ--VQRDL--NQSQCQMKE-----LKHMYQD-EQGKV------NK
YVGKQESMLERLSQLQSENTLLRQQLDDAHNKA---DCKEKRVINIQD----QFHEIVKT
LQGES-EKQSLMLEDRNKELLHEC-SHLKERLCQYEKEKGER EV--VVRQLQQELADT--
--LKKQ------SMSEASLEVSSRYRINLEDETQDLKKKLDQTRSQ-LEEAQDQHTEAVR
HAEK-----------------------------------MQERLQKLELENSRLKVKIKK
QAGKTEHLQ----KNVLSTNLSE-------------------------------------
-------------------------------ND---KE-QLKKL---TELKQSLEYT-LD
EEKKKNNELKKELTGFKK-----LFKMTE--------------TKLNA------EENGE-
---F-YFHGDLKSSEFEMDIPINMIIHKIDNLAAKLETTSSKCLHLDKN-----------
-NQFL--HQELLSLKNIQKKCETLEKNKRKLEQEVVNLKRY---IEE-NVVEHGQLQQY-
KQEIEERARQDL-VEKLKQVNL---FLQTQAA-SQGHSEQ-LGES-NNASM RSQMELRIK
DLESEL-SKMKT-QEDS------NEIQLEKYK----QLYIEEFKTRKSLS-SKLNKANER
LEEANTKLLVEKQQ---SRSLLS------TVSTRPVLECPCVGNLHHSLALHRSFPPREN
LVV-HTLNPQPSNNS-MESYLTKMRQELENSITRELREA-TAE-----LEA---------
---------------------FKVPPRGSA---------HKS------SQDLISEASQEY
KEILRRR--YMI------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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----------------------MKSQLEHQKVE-WEREL--YSLRLTLKQEKEKRRSAEI
LY-INIKEQ----LRSKEE-----------------------------------------
------------------------------------------------------------
--------LSE-VSPPHEKEKG---LLHE------NRMLQDELAMLRLEIDTIRNQKQ--
EKRYCEDTETEKEKNDSLQNAIKLNE----------------------------------
---------------------------------------------DEKLNR-----------ERLEAKLQSYRARLATAVQDR--DQSQASKRDLE----LAFQRAKDEWCHLQDKMNFEMSNLKDNNEVLS--------------------------Q-QLSEVESKFNA--LEIELQYTR-DALREKTLA-LEH--LQRNP--KQTQGQKKE-----IEQKSQN-EQGKV------NKYMGKHESLEEKLSQLKIENMLLREQLDDAYSRV---ECKEKTIIDLKD----QVQVIVRMVRVAG-EKRALLLREKNKELINKC-KQIMERAFRYEDEKEERER----------------------------------------------------------------QEAKELQTKVV----------------------------------------------RLEVENAELKVTVKEQAGQIEQLQ----KDLLSSSSCGDE-----------------------------------------------------------------KEN---L----KKC---MELKQPLQFR-LDQEVKKNEELEKENTGLKNH----LINMLR--------------RILSK------YENGE----L-PFYGDLKTSQTEMEIQINMLRQKIGDLRARLETESSRCIDLDAK------------NQVL--QQELLSMKATERECEKLKQIKKNLEEKVVNLRSH---AEV-NVVQGIQVEKYYKWEIDQRVRLIV-EERLKEVNL---FLQRQAA-SQENLEQ-LRAS-HDASIRSQVALRIKELESELQSQIRNSQE--------LKIELEKYR----QLYLEESEMRMSLT-KKLSKTNERLADITTKYLVERQQ---NRPFHS------TLTMGPVLEGPSVGNLTSSLLLDRNVTPRENVMI-PTSRPQTSVSN-IETHLFKMQQMLEDSIIRELKEV-AHD----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DEKLNR---------
--ERLEAKLQSYRARLATAVQDR--DQSQASKRDLE----LAFQRAKDEWCHLQDKMNFE
MSNLKDNNEVLS--------------------------Q-QLSEVESKFNA--LEIELQY
TR-DALREKTLA-LEH--LQRNP--KQTQGQKKE-----IEQKSQN-EQGKV------NK
YMGKHESLEEKLSQLKIENMLLREQLDDAYSRV---ECKEKTIIDLKD----QVQVIVRM
VRVAG-EKRALLLREKNKELINKC-KQIMERAFRYEDEKEER ER----------------
------------------------------------------------QEAKELQTKVV-
---------------------------------------------RLEVENAELKVTVKE
QAGQIEQLQ----KDLLSSSSCGDE-----------------------------------
------------------------------KEN---L----KKC---MELKQPLQFR-LD
QEVKKNEELEKENTGLKNH----LINMLR--------------RILSK------YENGE-
---L-PFYGDLKTSQTEMEIQINMLRQKIGDLRARLETESSRCIDLDAK-----------
-NQVL--QQELLSMKATERECEKLKQIKKNLEEKVVNLRSH---AEV-NVVQGIQVEKYY
KWEIDQRVRLIV-EERLKEVNL---FLQRQAA-SQENLEQ-LRAS-HDAS IRSQVALRIK
ELESELQSQIRNSQE--------LKIELEKYR----QLYLEESEMRMSLT-KKLSKTNER
LADITTKYLVERQQ---NRPFHS------TLTMGPVLEGPSVGNLTSSLLLDRNVTPREN
VMI-PTSRPQTSVSN-IETHLFKMQQMLEDSIIRELKEV-AHD-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------MRKLLSFGRRLG------------------------------
--------------------------------------------------------QALL
SS----------------------------------------------MD-QEYAGRGYH
IRDWELRK-----IHR---------------AAIKGDA----------------------
AE---VEHCLTRRF-RD--LD-ARDRK------------------DRTVL----------
----------HLAC--VHGRVQVVTLLLDRRCQINI--CDRLNRTPLMK-----------
-AVHCQEEACAIILL-KHGANPNIKDIY----GN--TALHYAV-YNEGTSLAEKLLSHHA
NIEALNKE-G---NTPLL------FAINSRRQHMVE-FLLKNQAN--------IHAV---
-DNFKR-------TA-LILAVQ--HNLS--SIVTL-------------------------
--LL-QQN-IHI--------SSQD------MFG-QTAED---YA-FC---CDL---RS--
--IQQQILEHKNKMLKNHLRNDN-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------Q--------------
----------G----K--T-----------------------------------------
-------------------------------------------SD-------I-------
-----------------------------SLYHQS--GVQWHDLR---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------L----------------------------------------------------
------------LQPSPPR-----------------------------------------
------------------------------------------------------------
----------------------------------------------------------FK
-QFSCLSL-------------------------------------------PR-------
------------------------------------------------------------
-------------------------------------------------SW--DNRHMRP
CPGN--------------------------------------------------------
-------------F----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------FFK
------------------------------------------------------------
----------------------------SF-------ILTKHMDL---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------SAEHNLKVASEEKQERLER--SENKQPQDS---------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
--------------QSYGKKKD---AMYG------NFMLKRDIAMLKQELYAIKNDSLRK
EKKYIQEIKSITEINANFEKSVRLNEEMIT--------KKVAQYSQQLNDL-K------A
ENARLNSK-----------------------------------LEKEKHNK---------
--ERLEAEVESLHSNLATAINEY--NEILER-KDLE----LVLWRADDVSR--HETMGSN
ISQLTDKNELLT--------------------------E-QVRKARVKFNT--LKGKLRE
TR-DALREKTLA-LES--VQLDL--RQAQHRIKE-----MKQMHPN-GEAKE------SQ
SIGKQNSSEERIRQRELENLLLERQ-LEDARKE---GDNKEIVINIHR----DCL-----
---EN-GKEDLL-EERNKELMNEY-NYLKEKLLQYEKEKAER EV--IVREFQEELVDH--
--LQKF------SMSESPLEGTSHCHINLDE-TWTSKKKLFQVEIQ-PEEKHEEFR----
------------------------------------------------------------
-------------K----------------------------------------------
-------------------------------------------L---SELISLLNYT-AD
QIRKKNRELEEEATGYKKC-----LEMTI--------------NMLNA------FANE--
--DF-SCHGDLNTDQLKMDILFKKLKQKFDDLMAEKEAVSSKCVNLDKD-----------
-NEVL--HQELLSMRKVQEKCEKLEKDKKMLEEEVLNLKTH---MEK-DMVELGKVQEY-
KSELDERATQAI-EKLEEI------HLQKQAE-YEKQLEQ-LNKD-NMASL-K KKELTLK
DVECKF-SKMKTAYED-----V--TTELEEYK----EAFAVALKANSSMS-EKIMKSDKK
IAVISTKLFMEKER---MEYFLS------TLPMRPDPELPCVENLNSIE-LNRKYIPKT A
IRI-PTPNPQTSNNC--KNSLTEMELDCAEQIITETKKR-PPL-----VERAEIGEHLWE
ALILALGPGGDSDEDLGAPQFHSASPL-------------DTPRTTRTTPSWPCHQAQ-S
GSM-ITK--MQVQRQPPYLVPASDPPWWPNMEEARAACSQLPCSPRWHLGLGKSLSKWKL
ETLMSLEGRVNVASEQPWQPAASSHPTCLNATTVLQMEPHRGNEQQAQEQGVRCLWGSSP
CMRAPTELWASWVPRGRPQAILRRTPCSSAERAQSEWESKIDGFECFTKKMETQGTQLNF
SANELTCKQIMVTGFKKEHQ KPIQELDPVMDLLVLSQGHQVNILDIIHIHKEALTKVMES
RQHVAEGKTEVQRLMMSESQEQDFFGHCG

MVA-----EVSPKLAASPMKKPFGLRVK--------------------------------
------------------------------------------------------------
-------------------MGKW-CCCCFPCCRGSGKNNVGARGDHDD---SAFTEPRYH
VRREDLGK-----LHR---------------AAWWGEV----------------------
PR---ADLIVMLRG-PG--IN-KRDKKK------------------RTAL----------
----------HLAC--ANGNSEVVRLLLDRQCQLHV--FDSKKRTALIK-----------
-AVQCQEDECALMLL-QHGTDPNLPDTF----GN--TALHYAV-YNEDKLMAKTLLLYSA
DIESKNKG-G---LTPLL------LAVHGQKQRMVK-FLIKKKAN--------LNAL---
-DRFGR-------TA-LILAVH--CGS-A-SIVSL-------------------------
--LL-QQN-IDV--------FSQD------VFG-QTAED---YA-VS---CHH---NI--
--ICQLLSDYKENQMPKNSSGN--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------SNPEQ-----------
---------DLKLTSEE------------------EPQ------------RLK-------
--------------------------------GSENS-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------QHE--------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------KKTQEPDINK-----------
---DCDREVE--------------------------------------------------
---------EEMQKHG--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----SNN------------------------------VGLS------------------
------------------------------------------------------------
-----------------------------------------E-------NL---------
--------------------------------------------------TDG-------
------------------------------------AAA---------------------
---G---------NG---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------D-GGLV---------------------------P----
----Q-------------------------------------------------RKSRKH
----------------------------------------ENQ-----------------
--QFPNTE------------------------------------------------IE--
------------------E-----------------------------------------
----------------------------------------------------YH------
-RPEKKSNENN-------------------------------------------------
------------------------------------------------------------
-----------------------------K------------------------------
-------VKSQIHSV---------------------------------------------
------------------------------------------------------------
-------------------------------DNL---DD---ITWPSEIASEDY------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------DL
------------LF---SNYETFMLLIEQLK---MD--FND--SASLSKIQDA----VIS
DEHLLEL---KNSH-------------------YEQLTVEIEQMENM-------------
--VHVLQ----KELCEAK---ETQLELAHQKFE-WEQER--YSLS---------------
------------------------------------------------------------
------------EEQNDTQKQLSKEQNARILRDEIL-----TN---K--QKQIEVAE---
-KKMSSEISLG-----HKEEKE---LLHE------NSMLQEEIAMLRIELDTIKHQNQLR
EKKYLEDIKSVKEKNDNLLKAIQLNEEALT--------KAVVQYSGQ-------------
------------------------------------------------------------
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-----------------------------

------------------REKIFGFGKKRK------------------------------
--------------------------------------------------------QPGH
SPSS-----------------------------------------------------RAS
RRERALGR-----LHR---------------AAAGGDL----------------------
GR---LQQLL-KK--HD--VN-QLDKE------------------NRTPL----------
----------HLAC--ANGHSDVVSYLVDNKCKLNL--CDNDNRSPLMK-----------
-AVQCQQEKCVTLLL-EHGADPNLVDVN----SN--TAFHLAA-HTANISLAVQLLEYNA
HIDAQNKE-G---YTPLA------IAITENHQEMVE-FLLKKGAD--------VHAR---
-DKSKR-------TP-LMIAAS--GGEL--KLIQV-------------------------
--LL-RYG-ADV--------SHKD------ING-WTSED---YA-LI---GGY---S---
------------------------------------------------------------
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-----------------------------

------------------MKKIFGL---G-----SK------------------------
--------------------------------------------------------QGQP
PPGF--------------VTRLQKIRGTVAC--------------DTGSIDETFTEPRYH
IRTRDLGK-----IHK---------------AASRGQV----------------------
DK---VQQLLLLG-KSR--VN-DRDSN------------------RRTAL----------
----------HLAC--AKGHIKVVRLLLSRKCEVDV--GDNEGRTPLMK-----------
-AVQYQETECAFNLL-EYGADPNVTDDY----GN--TALHYAV-YNGNMVLITKLLSCGA
NIEAKNKK-Q---LTPLL------LAINGKSLKTVE-FLVKNKAD--------TNAVD--
--RHES------------------------------------------------------
------------------------------------------------------------
--IHQVLSEYMQKSVN-P-ENPK-----NPTENI-----------------NPV----VG
ETT---------EHSVNSLRGRNQ----VHVQSGQR------------------------
------------------------------------------------------------
------------------------------------------------------VTLGS-
--------MNEGF-RK--E--I---L-------LGVMTSLAK--INPRNEGYVGSLYIIL
GNKNYHE--DFDSDTKH---------------------HMLFQSKV--------------
-----------T--------ASIPH-RALT----------HGRVK------------N--
------------------------------------------------------------
------------------------------------------------------------
-------------------------------PSL--------------------------
---------------------------P--------------PSL-----KSPILSLTEE
--------------------GP--------------------------------------
------------------------------------------------------------
-----------------------------------RKQATGKKQTGIGIVECASHKETSN
-----DN-----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------F-----------------------------IFVYK-----NNRGDVMT-AL--
GSE-QEAAREKESVWVLKSLSEDFDDP---------------------------------
-----------AGAADPGEST--------VNEQGEESLFIPSSSFSR--RN---------
---FK---IAE-VE--------------------------------DTKLQNL-------
------VLIHIRSSEEHHS-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------L-------KPAIEMKV-SI-PEK-EIR----------------------
-----------------------------------MKNIPTSTSGKYGLKLTPEEKQQRL
--------------EGNENNNQPQVE------EWK------------K---H---KSKEV
EI---------------------------------------------------------S
KSPCDGDADDS-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------D----------------------SEASIPQRESGK-GGN-----------
-QHFGRKDNEELDSSGRALYMKKVR-----------------------------------
------------------------------------KKKK--EKWTSKESKMTPVLEEAN
L-LTSDLLQRNDNCRLSEVYQ---------------------------------------
--------------------------L-------HGWPAKK-------TSH---------
-------------------------------------------EK---------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------NKGE-----------
---------------------------------THIH---------SQDH----------
-------------------------------------------------------L-EDL
TWSSEMASEDQLLP--AFNPKACALLIEQLA---MH--CKD--NASMSEIQQA----LLS
YERIIKN---QGSH-------------------CEQLKVKIKKLENA-------------
--VCDLQ----KELSVTE---GVKSQLEHQNTE-REQEL--CNLRLSLEEEKEKRTNADV
DC-EKMRRK----LRRIEEQ------------------YMEEVKMKQQLQKALRTQDAEV
KSLKINLN-EIINNREALAKVESGDLGGNLKIVYIF-----NHSFSE---K-IRKYI---
-DSSQGKKGNQ-ISHSGEKDKD---LLYE------NRLLQDEIARLRMKVDLIKTQTQEK
KPESLEDIETIKE----LRNSIKLKKERLA--------EAMSEQSGQLRLL-R------S
ENTLLKFE-----------------------------------VDFEKREK---------
--EKLKTEVQSNLHKLAAVLNDL--HQSQKSQKDLE----FSFQKARDEWS--VVQE---
--NMSSYSHILF--------------------------Q-KLVEAERKFNS--LEVELSN
TK-DVLRQKTLA-LEG--VQRDL--SQAECEKKE-----IELKYHN-EQRKM------NT
YLAEEELAEERLAALRSRNTLLQQQLSHAQDKA---DNKEKMIIDIQT----QFQATVKE
LQAKS-ERQRLLLEARNKDLTAKC-SHLKERQNQYKIERAEREV--VVRQLRRELAEA--
--LHKL------PRSDATLDITSRCHIHSED-TARAKKKCSQITNK-LQEAQGQLTVTVR
D-----------------------------------AT-RDDYMKKLEEENFKLKVTIRE
QEGRMEQLQ----ETLSST-----------------------------------------
------------------------------RSVR---Q-TGKGF---HVSETLYKNI-LD
NMTLQT-QLLHELTEARRL-----AGKME--------------DHMQM------YNLN--
--QN-NFRTEIENSQLKARSQ-------KSPVKHRVGKLISKFLSYHSGILLLQQGSPEL
PPQGL--FIKVL-----HKRRGELKCKTPSLR---ISLKSP---PSR-SLKGKKRMRKY-
G--LQD---TPL-KKKTETFFCIVKFLETQIP-ALENLEQ-PRKN-QIASWGSEMELDVP
ETELSI-ADVQSELSR-----IRESQKLEEYT----QVRMNELQTLKCLS-TKVCQLHEN
LAEVETQLSGIKQM---DRSLHT------TLTTRPILEARHLENPNHAL-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

--------------MSFSMKKIFG----AK------------------------------
---------------------------------------------------------EKT
PLGF--------------CDAPQMTVSEFFF--------------GE-----NPNYPKYH
TTYRPLGH-----IHR---------------VAAEGDA----------------------
AR---MEILLTLG-QCN--VY-HRDRK------------------DRTAL----------
----------HFAC--VYGRLPVVTILVKNNCEIDA--LDKNHTTPLMK-----------
-SVQCWKQKCATVLL-EHGADPNIRDSS----GN--SALHYAV-YNGHQEMASLLLQYNA
DIEQKTKD-G---FTPLL------LALREKRVEVAE-FLVRMGAD--------IHVV---
-DELQR-------NT-LIYAIR--CGSK--DLSVL-------------------------
--LL-EKG-IDF--------FYKD------VFG-WTALR---YA-IE---GHC---T---
--FRQTLLDFEESLHSNKKDKEPELQVEPSTSCILAK--------QIDAGNDSLARISS-
CPSPETPVLTMKED--ENSDARSN------SESKPPNCAGNSPAAIDKAFGNRGKRTVEA
W------VEKDPSS----------ESAAEVRD-----SVTNEAVERIKLLPSE-------
-------TELEL-----------------------------MSVEEDVSHESEND--HPL
RESEHLPKIKVGHSSR--SGYQ-----------MGKM---NI--NRQMKGRI--NI----
-------------LLKI------------------YVITYLFKTG-HCYM-IL-------
-------------KHY--------------------------------------------
------------------------------------------------------------
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-----------------------------

------------------MKKFFPFRGKRK------------------------------
--------------------------------------------------------TDDS
-------------------HSRSSEV-----PI----------SLANTAPLSLSIGGGYH
LRDKHLKK-----LHK---------------AATTGNE----------------------
QK---LKDYLERRK-YN--VN-GRDKR------------------SRTPL----------
----------HLAC--ANGYTNIVSLLIENQCKINV--QDSENRTPLIK-----------
QAVECQQESCATVLL-LHGADPNLVDVY----SN--TALHYAV-CGQNISLANKLLQYKA
NLEAKNKD-G---HTPLL------LAVAENNENMVK-FLLKKGAD--------VNAS---
-DKNHR-------TA-IMIALI--VEPT--SSVKL-------------------------
--LL-QQD-TDL--------AHKD------IYG-FTAEE---YA-SF---NGF---TM--
--YHQITANNENKKKT--EQTAY-------------------------------------
------------------------------------------------------------
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-----------------------------

------------------MKKIF---SKKG------------------------------
--------------------------------------------------------ESPL
GSFA----------------RRQRSSAGGGG----------------EPGEGAYSQPGYH
VRDRDLGK-----IHK---------------AASAGNV----------------------
AK---VQQILLLRK-NG--LN-DRDKM------------------NRTAL----------
----------HLAC--ANGHPEVVTLLVDRKCQLNV--CDNENRTALMK-----------
-AVQCQEEKCATILL-EHGADPNLADVH----GN--TALHYAV-YNEDISVATKLLLYDA
NIEAKNKD-D---LTPLL------LAVSGKKQQMVE-FLIKKKAN--------VNAV---
-DKLES-------SH-QLISEY--KEER--IPKHSSQNSNSVDESSED------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------SLSRLSG--KPGV--------------D----D--SWPTSDD---------
--------EDLNFDTKN-------------------VPKPSLAKLMTASQQSRK---NLE
ATYGTVRT------------------GNRTLFEDRDSDSQ--------------------
---------------------D-------------------EVVV---------------
------------------------------------------------------------
-----------------------------ESLPT--------------------------
----------------------------------TSIKVQCFSHPT--YQSPDLLP-KPS
HKS---------------------------------------------------------
----------------------------------------LANP----------------
-----------------------------------GLMKEEPTKPGIAKKE---------
---NGIDIIE----SAPLE--------------QTNNDN-------------LTYVDEVH
KNN----RSDMMSALGLGQEEDIESPWDSESI-SENFPQKYVD---------------PL
AGAADGKEKNIGNE---Q------AED----------------------------VFYIP
SCMSGSRNFKMAKLEDTRNV--------------GMPVAHMESPERYLHLKPT----IEM
-KDSVPNK-----------------------------AGGMK------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------DV------------------
---------------------------------------------QTSK-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------AA
EHDLEVASEEEQER-EG-------------SENNQPQVE--------EERKKHR------
---------------------------NNEMEVS---ANIHDGATDDAED----------
DD---DDDGLIQ---------KRKSGETD----HQQFPRKENKEY---------------
---------ASSGPALQMKE-VKSTEK--EKRTSKESVNSPVFGKASLL-----------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------TGGLLQVDDDSSLSE-
-------------------IDEDEG---RPTKKTSNEKNK---VKNQIQSMD--------
------------------------------------------------------DV-DDL
TQSSETASEDCELP--HSSYKNFMLLIEQLG---ME--CKD--SVSLLKIQDA----ALS
CERLLEL---KKNH-------------------CELLTVKIKKMEDK-------------
--VNVLQ----RELSETK---EIKSQLEHQKVE-WEREL--CSLRFSLNQEEEKRRNADT
LY-EKIREQ----LRRKEEQ------------------YRKEVEVKQQLELSLQTLEMEL
RTVKSNLN-QVVQERNDAQRQLSREQNARMLQDGIL-----TNHLSK--QKEIEMAQ---
-KKMNSENSH-----SHEEEKD---LSHK------NSMLQEEIAMLRLEIDTIKNQNQEK
EKKCFEDLKIVKEKNEDLQKTIKQNEETLT--------QTISQYNGRLSVL-T------A
ENAMLNSK-----------------------------------LENEKQSK---------
--ERLEAEVESYHSRLAAAIHDR--DQSETSKRELE----LAFQRARDECSRLQDKMNFD
VSNLKDNNEILS--------------------------Q-QLFKTESKLNS--LEIEFHH
TR-DALREKTLG-LER--VQKDL--SQTQCQMKE-----MEQKYQN-EQVKV------NK
YIGKQESVEERLSQLQSENMLLRQQLDDAHNKA---DNKEKTVINIQD----QFHAIVQK
LQAES-EKQSLLLEERNKELISEC-NHLKERQYQYENEKAER EV--VVRQLQQELADT--
--LKKQ------SMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQ-LQEAQDRHTEAVR
C-----------------------------------AEKMQDHKQKLEKDNAKLKVTVKK
QMDKIEELQ----KNLLNA-----------------------------------------
------------------------------NLSEDEKE-QLKKL---MELKQSLECN-LD
QEMKKNVELEREITGFKNL-----LKMTR--------------KKLNE------YENG--
--EF-SFHGDLKTSQFEMDIQINKLKHKIDDLTAELETAGSKCLHLDTK-----------
-NQIL--QEELLSMKTVQKKCEKLQKNKKKLEQEVINLRSH---IER-NMVELGQVKQY-
KQEIEERARQEI-AEKLKEVNL---FLQAQAA-SQENLEQ-FREN-NFASM KSQMELRIK
DLESEL-SKIKTSQE------DFNKTELEKYK----QLYLEELKVRKSLS-SKLTKTNER
LAEVNTKLLVEKQQ---SRSLFT------TLTTRPVMEPPCVGNLNNSLDLNRKLIPREN
LVI-STSNPRASNNS-MENYLSKMQQELEKNITRELKEA-AAE-----LES-----G---
--------------------S-IASPLGST---------DES----NLNQDLVWKASREY
VQVLKKN--YMI------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------MRKLFSFGRRLG------------------------------
--------------------------------------------------------QALL
SS----------------------------------------------MD-QEYPGPGYH
IGDWELRK-----IHR---------------AAIKGDA----------------------
AE---VERCLTRRF-QN--LD-ARDRK------------------DRTAL----------
----------HLAC--AFGRVEVVTLLLGKGCQIDV--CDRLRRTPLMK-----------
-AVHCQEEACAIILL-EHGANPNIKDIY----GN--TALHYAV-YNQGTSLAEKLLSHHA
NSEARNEE-G---NTPFL------FAINSGRQHMVE-FLLKNQAN--------VHAV---
-DNFRR-------TA-LILAVQ--RSSS--SIISL-------------------------
--LL-QQN-INI--------FSQD------TFG-QTAED---YA-VC---CDL---RS--
--IEQQIL---E------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------H--------------
------------------------------------------------------------
-------------K-----------------------------NK-------I-------
-----------------------------LK----------NRLR---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------N----------------------------------------------------
------------DNQETAT-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------MK-------------------------------------------SA-------
------------------------------------------------------------
-------------------------------------------------NL--K------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------K
------------------------------------------------------------
----------------------------RK-------EGAKA------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------EHNLTVASEEKQERLER--SENKQPQDS---------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
--------------QSCGKKKD---VMHG------NYMSKRDIAMLKEELYAIKNDNLRK
EKEYIHEIKSITEINANFEKSVRLNEEMIT--------KTMAQYSQELSDL-K------A
ENSRLNSK-----------------------------------LEKEKHNK---------
--ERLEAEVESLHSRLATAANEY--NEILER-KDLE----LVLLRADEVSR--EEKMGSN
ISQLTDENEFLT--------------------------K-QLSKARVKFST--LKAKLCE
TR-DALREKTLA-LES--VQLDL--KQAQHQIKE-----TKQMHPN-EEAKE------SQ
STGKQNSLEERIHQEELKNLLLE-L-LKDALKE---GNNKEVVINIQG----GCL-----
---EN-GKEDLLLEEKNKELMNEY-NYLKEKLLQYEKEEAEG EV--IVRQLQEELADH--
--LKKF------SMSESPLEGTSHCHINLDE-TRTSKKKLFQVESQ-PEEKHEEFR----
------------------------------------------------------------
-------------K----------------------------------------------
-------------------------------------------L---FELISSLDYN-VD
QIRKKNHELEEEATGYKKC-----LEMTI--------------NMLNA------FGNE--
--DF-SCHADLNKDQVKMDILFKKLKQKFDDLMAEKEAVSSKCVNLAKD-----------
-NEVL--HQELLSMRKVQEECEKLEKDKKMLEEVVLNLKTH---MEK-DMVELGKAQEY-
KLELDEGTRQAI-EKSVEI------QSQERAE-NEKQLEQ-LNRD-NTALL-K KKELTLK
DVECKF-SKMKTAYEE-----V--TTELEEYK----EALAITLKANHSMS-KKLMKSDEK
IAMISTMLLMEKQQ---IKYFLS------TLPMTPDPELPCV-NLNSIG-LDRKYSPKTA
IRI-PTSNPQPSNNC--KNSLTELLLCWALA------PV-YFL-----L-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------MNKLFSFWKRKN------------------------------
--------------------------------------------------------ETRS
-----------------------------------------------RTSSDPFIGQGYN
LREKDLKK-----LHR---------------AASVGDL----------------------
KK---LKEYLQLKK-YD--VN-MQDKKNR----------------HRTPL----------
----------HLAC--ANGHRDVVLFLIEQQCKINI--RDSENKSPLIK-----------
-AVQCQNEDCATILL-NCGADPNLRDVH----YN--TALHYAV-CGQSFSLVEQLLDYEA
DLEAKNKD-G---YTPLL------VAIINNNTKMVK-FLLEKGAD--------VNAS---
-DNHQR-------TA-PILAVS--GEPT--RLVKL-------------------------
--LL-QQG-VEL--------SCQD------ICG-FLRNM---LI-SV---VLL---YR--
--YAQFTVSHGKKKHV--K-----------------------------------------
------------------------------------------------------------
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-----------------------------

------------------------------------------------------------
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-------------------------------------C----------------------
SA---VR-----QT-AS--FK-PVIFS------------------YRTPL----------
----------HLAC--ANGYTNIVSLLIEKKCKINV--QDSENRSPLIK-----------
-AVQYQKENCATVLL-YHGADPNLLDIH----YN--TALHYAV-CGHSVSLVEKLLKHKA
NLEAKNKD-G---YTPLL------LAVSENKAEMAE-FLLEKGAD--------VNTS---
-DKNQR-------TA-LMISLS--EEPT--SIVSH-------------------------
--LL-QYD-VDL--------TCQD------IYG-FTAEE---YA-SF---NGF---TI--
--IRSYLQNHNFKLLY--NHR---------------------------------------
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-----------------------------

------------------------------------------------------------
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--------MTKRKKTIN--LN-IQDAE------------------KRTAL----------
----------HWAC--VNGHEEVVTFLVDRKCQLDV--LDGEHRTPLMK-----------
-ALQCHQEACANILI-DSGADLNLVDVY----GN--MALHYAV-YSEILSVVAKLLSHGA
VIEVHNKA-S---LTPLL------LSITKRSEQIVE-FLLTKNAN--------ANAV---
-NKYKC-------TA-LMLAVC--HGSS--EIVGM-------------------------
--LL-QQN-VDV--------FAAD------ICG-VTAEH---YA-VT---CGF---HH--
--IHEQIMEYIRKLSK-N-HQNT-----NPEGTS------------------------AG
TPDEAAPLAERTPDTAESLVEKTPD-EAAPLVERTPDT----------------------
-----------------------------------------------------AESLV--
--------------------------------------------EKT------PDEAAS-
--------LVEGA-SD--K--I---QCLEKAT-SGKFEQSAE--ETPRE--------ITS
PAKETSE--KFTWPAKG------------------RPRKIAWEKK-DTPREIM-------
------SPAKETSEKF-TWAAKGRP-RKIA----------WEKKE------------T--
------------------------------------------------------------
------------------------------------------------------------
-------------------------------PVK--------------------------
---------------------------T--------------GCVA--RVTSNKTKVLEK
G-------------RSKMIACP--------------------------------------
------------------------------------------------------------
-----------------------------------TKESSTKASAN--------------
------------------------------------------------------------
---------DQRFPSESKQEEDEEYSCDSRSL-FESSA----------------------
----------KIQVCI-----------------------PESIYQKVMEINIEVE-----
------------------------------------EPPKMP-----SAFKPA----IEM
-QNSVPNK-----------------------------AFELKNEQ--TLRADPM---F--
PPE-SKQKDDEENSWDSESLRETVSQK---------------------------------
------------------------------------VVCLPKATHQK--EI---------
---DK---INGKLEGKNRFL--FKN-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------HLTEYFSKLMRKD------------------------------------
----------------------------------ILYL----------------------
--CETVSQKDVCLPKAT---HQKE---------------IDKINGKLEES-----P----
-----------------------------------------------------NKDG---
-L---------L-------KATCRTKV-SI-PTK-ALELKDMQTF-----KAE---PPEK
PSAFEPA---------------IEMQKSVPNKALELKNEQTLRADE----ILPSESKQK-
---------------------DYEEN------SWD------------T---E---V----
------------------------------------------------------------
-PSCLPKAYTH-------------------------------------------------
----------AK------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------H----------TQYTV--
------------------------IILP--SESKQKDYEE--NSWDTESLRE--------
------TVSQKVVCLPKATHQKEIDKINGKLEGKNRFI----------------------
----------------------------------------F-------KNHLTKYFSKL-
-------------------------------MRKDIL-YCVLFA--IGE-----------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------KK-HIC-TATHVYNLSYTLRI-
-----------------------------DQRFSNFR---------K-------------
---------------------------------------------------------SAE
NLVNNSLRETVSQKVVCLPKATHQKEIDKIN---GK--LED--STSLSKILDA----VHS
CERAREL---QKDH-------------------CEQLTGKMEQMKKK-------------
--FCVLK----KKLSEAK---EIKSQLENQKVK-WEREL--CSVRLTLNQEEEKRRNADI
LN-EKIREE----LGRIQEQ------------------HRKELEVKQQLEQALRIQDMEL
KSEGSNL-----------------------------------------------------
---------NQ-VSHTHENEND---LLNE------NCMLKKEIAMLKLEIATLKHQYQEK
ENKYLEDIKILKEKNAELRMTLKLKEESLT--------KRASQYSGQLKVL-I------A
ENTMLTSK-----------------------------------LK-EKQDK---------
--EILETEIESHHPRLASAVQDH--DQIVTSRKSQE----LAFHIAGDACL--QRKMNVD
VSSTIYNNEVLH--------------------------Q-PLSEAQRKSKS--LKINLNY
AG-DALRENTLV-SEH--AQRDQ--RETQCQMKE-----AEHMYQN-EQDNV------NK
HTEQQESLDQKLFQLQSKNMWLRQQLVHAHKKA---DNKSKITIDIHF----LE------
----R-KMQRHLLKEKNEEIFNYN-NHLKNRIYQYEKEKAETEV--SIKKYKYLSN-F--
--LK---------ESLKSYLALAKC-----------------------------------
------------------------------------------------------------
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-----------------------------

------------------------------------------------------------
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-----------------------------------------------TAL----------
----------HVAC--ALGSKEAAELLLKL-LPGQS--RDSFKRTPLIK-----------
-AIQQQL----FKLL-ERGADPNAMDIH----GF--TALHYAV-HYDHRCLARLLLQN--
-IEAKDKV----------------------------------------------------
------------------------------------------------------------
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-----------------------------

------------------MKKIFGFRS-KG------------------------------
--------------------------------------------------------PSPL
GPSA----------------RPRSNCVGFGR----------------ESA-SGSHVPRYH
IHDKDMGK-----IHK---------------AASVGDV----------------------
AK---VQHILILGK-SG--VN-DRDKK------------------DRTAL----------
----------HLAC--AYGHPEVVTLLVERKCEIDA--RDSESSTALIK-----------
-AVQCQEEECAAILL-DHGADPNVMDSS----GN--TALHYAV-YSENTSMAAKLLAHNA
NIEAKNKD-D---LTPML------LAVKENKQHIVE-FLVKKKAS--------IHAV---
-DQLGS-------N--RQMFEY--DGKR---LQ-RSENSNPVDNGSED------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------GSLTRSYN--TPGP--------------A----D--SWPTSDE---------
--------EDYNFDNKN-------------------VPKINLTELWTAAQQSRKN----Q
TKCGFEEL------------------DNGARFDDSDSPSE--------------------
---------------------S-------------------EDAI---------------
------------------------------------------------------------
-----------------------------EVEPA--------------------------
----------------------------------PSVRVQTL-SPS--RQSPDP------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------VEGATELAIEGEE---------
---NGTDVIE----SASQE--------------QPNHDN-------------LTRADGWH
KSN----KSEMMSALGLGEDEDEHSPWDSESI-SESVSLKDVG---------------HF
SGTADQTGKRRAHG---Q------IED----------------------------VTYIP
SCMSGSRSFKMAKLEESRNV--------------GLPVAHMEAPRKYAIMEPT----IER
-RAPVLNKTE---------------------------TVGMT------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------DAQT----------------
--------------------------------------------F---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------KS
EP--ESVSREEQTRLSG-------------SEDSQQKV---------EEKRKYK------
---------------------------NNEAEPS---GNLYSGAADGG------------
------A-DVKP-----------QSGDTE----NQQSPREGSEGR-----------G---
-----------SGPALLMKE-AKKMEN--EKWVSREPARTAMSERTGLP-----------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------TGGWPQMQDGSCWSD-
-------------------TDQSEA---RPTKKTSSKHNK---DSGQTAAVD--------
------------------------------------------------------NL-DDF
TESSETASEDHELQ--GPDSESILCAIEHLR---LE--CKD--TASLLKIRDA----VYS
YKRLIEL---KRSH-------------------CELLTGKLKRMENK-------------
--YKGLQ----KEMSETE---EVKSRLEHEKVG-WEQEL--CRLRFALKQEEEKRRSADQ
LS-EKTSEQ----LRRKGEQ------------------CQSEVEARQQLEASLRTLEMEL
KTVKSHLN-QVLEERNETQRQLSREQNARMLQDGIL-----ASHLCK--QKEIEMTQ---
-KKMTSEVSV-----SHEKEKD---LLHK------NQRLQDEVAVLRLEMDTIKSHNQEK
EKRYLEDIKIANEKNDNLQRMVKLNEETFT--------KTIFQYTGQLNSL-K------A
ENTMLSSK-----------------------------------LDNEKQNK---------
--ERLETDVESFRSRLASALHDH--AEIQTAKRDLE----IAFQRARDEWFRVKDKMNFD
MSNLRDNNEVLS--------------------------Q-QLSKTERKLNS--LEIEFHH
TK-DELREKTLA-LKH--AQRDL--SQTQCQMKE-----VEHMFQD-EQGKV------SK
FMGKQESIEERLAQLQSENTLLRQQLDDAANKA---ESKDKTIVNIQD----QFQDVLTR
FQAES-QRHSLRLEDRNQELVSEC-SHLRERLCQYENEKAER EV--VVRQLQQELADT--
--LKKQ------SMSEASLEVSSRYRSNLEEEARDLKKKLGQLRSQ-LQEARDQHREAVH
H-----------------------------------AEKMEDHLQKLELEKSKFEITIKK
QSEEIDQLQ----ENLSRV-----------------------------------------
------------------------------NLSEEDKE-KLQKL---TELKESLECT-VD
QEQKRSSALEKELAEFKEV-----LKMTK--------------KELNE------YENR--
--EL-NLRQDIKNNHLEMDIPVSTLIKKIDDLTAKLETASSKCLHLGKK-----------
-NQLL--QQELLLMRTIQKKCGKLEKNKKQLEQEVVNLRSH---MEK-NMVEHSQAQQY-
AREVEERARQDL-VEKLKQVNL---FLQAQAA-SQESLEQ-LREN-SNASV RSQMELRIK
DLESQL-YRMKA-QE------DFDKIELEKYK----QLYQEEFRARKSLS-SKLNKTSEK
LEEASSKLLLEEQQ---NRSLLS------TLSTRPVVECPCVGSFHNSLVFNRTLIPREN
IVV-PTSGLQPSNKR-VEIYLTKMHQELEKSINRELKEA-TAE-----LES-----E---
--------------------FCRVSPLGSA---------TKA------SQDQLSDASQEF
IDILKKK--YMIC-----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------MKKLFTFWRR--------------------------------
--------------------------------------------------------SDGP
-------------------HSASSGQ-----LF----------PGAR---GAPQVQPGYS
LRDRDLKT-----LHK---------------AAALGDL----------------------
DK---VKEYLLLGK-HD--VN-APDRK------------------YRTPL----------
----------HLAC--AFGCSNVVSFLIEKQCKINV--FDSENKSPLIK-----------
-AVQCKNETCAAMLL-DQGADPNIMDFD----GN--TALHYAV-YGQSVALVKKLLEYKV
NLEAQNKD-G---CTPLL------LAVTENNAEIVK-FLLKRGAD--------ANAS---
-DQNQR-------TA-LMIALS--DEPT--NLVSL-------------------------
--LL-QKE-VDL--------SCQD------IYG-FTAEE---YA-SF---NGF---TI--
--YHHLIANYGNKKKV--KKISY-------------------------------------
------------------------------------------------------------
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-----------------------------

------------------MKKLFTFWKRKN------------------------------
--------------------------------------------------------EPHS
--------------------------------------------------------LGYN
LRDKDLKK-----LHK---------------AAAVGDL----------------------
EK---VKKYLQ--K-HD--VN-IRDREYRVTY--LYSYTTSLNYFTRTPL----------
----------HLAC--AYGYSNVVSLLIEKQCKINV--WDSENRSPLTK-----------
-AVQCEKESCATLLL-DQGADPDLVDLD----GN--TALHYAV-CGHSTSLVRILLQHKA
NLEAQNKD-G---YTPLL------LAIAENKAEMVE-FLLKRGAD--------VNAS---
-DNNQR-------TA-LMIALS--EEPT--SLVSL-------------------------
--LL-QQE-VDL--------SCRD------IMDSQLRNM---LL-LM---VLL---CR--
--YHQLIANYRKEKKI--KK----------------------------------------
------------------------------------------------------------
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-----------------------------

------------------MKKIF---SKKG------------------------------
--------------------------------------------------------ESPL
GSFA----------------RRRRSSAGGGG----------------EPGEGAYSQPGYH
VRDRDLGK-----IHK---------------AASAGNV----------------------
AK---VQQILLLRK-NG--LN-DRDKM------------------NRTAL----------
----------HLAC--ANGHPEVVTLLVDRKCQLNV--CDNENRTALMK-----------
-AVQCQEEKCATILL-EHGADPNLADVH----GN--TALHYAV-YNEDISVATKLLLYDA
NIEAKNKD-D---LTPLL------LAVSGKKQQMVE-FLVKKKAN--------VNAV---
-DKLES-------SH-QLISEY--KEER--IPKHSSQNSNSGKTSNSE--F-L-------
---L-VIT-KSC--------TVAQ------AG----------------------------
------VL----QHDLSSL-RSL-------------------------------------
LPG---------------------------------------------------------
---------------------------------------------------FT-------
-------Q----------------------------------------------------
FFCLHLPSSWDHRLSG--KPGV--------------D----D--SWPTSDD---------
--------EDLNFDTKN-------------------VPKPSLAKLMTASQQSRK---NLE
ATYGTVRT------------------GNRTLFEDRDSDSQ--------------------
---------------------D-------------------EVVV---------------
------------------------------------------------------------
-----------------------------ESLPT--------------------------
----------------------------------TSIKVQGFSHPT--YQSPDLLP-KPS
HKS---------------------------------------------------------
----------------------------------------LANP----------------
-----------------------------------GLMKVTR----HWKKE---------
---NGIDIIE----SAPLE--------------QTNNDN-------------LTYVDEVH
KNN----RSDMMSALGLGQEEDIESPWDSESI-SENFPQKYVD---------------PL
AGAADGKEKNIGNE---Q------AE----------------------------------
-----------------------------------------ESPERYLHLKPT----IEM
-KDSVPNK-----------------------------AGGMK------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------DV------------------
---------------------------------------------QTSK-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------AA
EHDLEVASEEEQER-EG-------------SENNQPQVE--------EERKKHR------
---------------------------NNEMEVS---ANIHDGATDDAED----------
D--DDHDDGLIR---------KRKSGETD----RQQFPRKENKEY---------------
---------ASSGPALQMKE-VKRTEK--EKRTSKESVNSPVFGKASLL-----------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------TGGLLQVDDDSSLSE-
-------------------TDEDEG---RPTKKTSNEKNK---VKNQIQSMD--------
------------------------------------------------------DV-DDL
TQSSETASEDCELP--HSSYKNFMLLIEQLG---ME--CKD--SVSLLKIQDA----ALS
CERLLEL---KKNH-------------------CELLTVKIKKMEDK-------------
--VNVLQ----RELSETK---EIKSQLEHQKVE-WEREL--CSLRFSLNQEEEKRRNADM
LY-EKIREQ----LRRKEEQ------------------YRKEVEVKQQLELSLQTLEMEL
RTVKSNLN-QVVQERNDAQRQLSREQNARMLQDGIL-----TNHLSK--QKEIEMAQ---
-KKMNSENSH-----SHEEEKD---LSHK------NSMLQEEIAMLRLEIDTIKNQNQEK
EKKCFEDLKIVKEKNEDLQKTIKQNEETLT--------QTISQYNGRLSVL-T------A
ENAMLNSK-----------------------------------LENEKQSK---------
--ERLEAEVESYHSRLAAAIHDC--DQSETSKRELE----LAFQRARDECSRLQDKMNFD
VSNLKDNNEILS--------------------------Q-QLFKTESKLNS--LEIEFHH
TR-DALREKTLC-LER--VQKDL--SQTQCQMKE-----MEQKYQN-EQVKV------NK
YIGKQESVEERLSQLQSENMLLRQQLDDAHNKA---DNKEKTVINIQD----QFHAIVQK
LQAES-EKQSLLLEERNKELISEC-NHLKERQYQYENEKAER EV--VVRQLQQELADT--
--LKKQ------SMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQ-LQEAQDRHTEAVR
C-----------------------------------AEKMQDHKQKLEKDNAKLKVTIKK
QMDKIEELQ----KNLLNA-----------------------------------------
------------------------------NLSEDEKE-QLKKL---MELKQSLECN-LD
QEMKKNVELEREITGFKNL-----LKMTR--------------KKLNE------YENG--
--EF-SFHGDLKTSQFEMDIQINKLKHKIDDLTAELETAGSKCLHLDTK-----------
-NQVL--QEELLSMKTVQKKCEKLQKNKKKLEQEVINLRSH---IER-NMVELGQVKQY-
KQEIEERARQEI-AEKLKEVNL---FLQAQAA-SQENLEQ-LREN-NFASM KSQMELRIK
DLESEL-SKIKTSQE------DFNKTELEKYK----QLYLEELKVRKSLS-SKLTKTNER
LAEVNTKLLVEKQQ---SRSLFT------TLTTRPVKEPPCVGNLNNSLDLNRKLIPREN
LVI-STSNPRASNNS-MENYLSKMQQELEKNITRELKEA-AAE-----LES-----G---
--------------------S-IASPLGST---------DDS----NLNQDLVWKASREY
VQVLKKN--YMI------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

MVA-----EVCSMPAASAVKKPFDLRSKMGKWC---------------------------
----------HHRFPCCRG-----------------------------------------
----------------------------------SGKSNVGTWGDYDD---SAFMEPRYH
VRREDLDK-----LHR---------------AAWWGKV----------------------
PR---KDLIVMLRD-TD--MN-KRDKQE------------------RTAL----------
----------HLAS--ANGNSEVVQLLLDRRCQLNV--LDNKKRTALIK-----------
-AVQCQEDECVLMLL-ELGADRNIQDEY----GN--TALHYAV-YNEDKLMAKALLLYGA
DIESRNKC-G---LTPLL------LGVHEQKQQVVK-FLIKKKAN--------LNAR---
-DRYGR-------TA-LILAVC--CGS-A-SIVNL-------------------------
--LL-EQN-VDV--------SSQD------LSG-QTARE---YA-VS---SHH---HV--
--ICELLSDYKEKQMLKISSEN--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------SNPGK-----------
---------EAEE-----------------------------------------------
------------------------------------------------------------
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-----------------------------

------------------MKKIF------K------------------------------
---------------------------------------------------------GHS
PW----------------------GFLSFRH------------------S-ENQEPPRYL
TGYMPVKR-----IHK---------------AASVGDI----------------------
PQ---VQKMLEFG-DID--VN-ITDRK------------------KRTAL----------
----------HYAC--AHGQSEMVSLLLWYDCNIEA--RDREESTPLIK-----------
-ATQRQHEICVKILL-ENGADSNAVDIH----QN--TSLHYTV-YNNDTTIAAKLLAFNA
DTEIKTKN-G---YTPLI------LAVLENKQEMVE-LLLQAAAN--------INAL---
-DNCKR-------SA-LIHAVR--TQSK--NMTSL-------------------------
--LL-QQG-ANE--------SLVD------IYG-ATAQS---YA-VF---ETF---Q--V
LSQ---------------------------------------------------------
GPGPR-SELTTKEARHN-FD----------TKDGLIPCSHSIKEDNKRMEENTDAVDE--
------------------------------------------------------------
--------------------------------------LGSFAHRPSNSEPIEVEDDPSL
--------------ST--KPPV-------------------I--QSPMLTES--SLWA--
-----------GYP--A------------------DWPEPIKFSRQPAVYNPT-------
-------------EW--REDMESRSV----PLES------K-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------QQVAV---LPGKK-------------------------------------
------------------------------------------------------------
-----------------------------------AKG----QTL---ELQSSRAVTEPG
ASSPDLPSGE-DAKDELV----------SL------------------------LASLEK
KKPQMK----EFP----------------------------------------------V
TEAAKCQTDVKL---QRQGVL-------EFEEKGLEICQDSN------------------
------------------------------------------------------------
--------LEA---------------------------------AESTESYSILRFTK--
PD------VSDPE-----------------------------------------------
----------------P-------------------------------------TSRKDE
YKFDTKDEDGLERHLLAPRASQHQA-----------------------------------
------KPTSPPPVQLQER--SR--EPEMGMA------------------------SDEE
DTSGLSKSAKGQILEGKLTLGEIPE---------------------GKETVQCVINKPTQ
KG--DAIYKD---------------VNAS-------------------------------
---VYLKEERPP-DVS-GKAHLTSAPTTLTY-NTLDCGDR--------------------
--DV---SAALVSEALRTSPRQEEGGLGNAFPSPSSSQDVDYSGQSLTKF-PLM----R-
-----NKLDCENNTSE--------LEESFHKRREKSS-----------------------
------------------------------------------------------------
----------KNIESRKVKGKCPEV-R------MGEKQGGHEFKSQSQKT----------
--------------------------VKPKRTDWQLDIGHMLKSSDDN------------
--------R-K--QQERSHVSEVK-------------------SWGD-STLVSDM----N
RKSKGTQDLFLKPLPCKGH----------CEAPARA---------------VG---TASD
APPGGQTTRAFANEELRD----RL-SDSEFRILE-------------EEILAWERVHLEN
ESVSENL-LNKCEGIISD---------ATD----------QQGQYLD----------M-D
Q----V-AEVD--SE-------------GTSQLEQ---KNLDSSE-NTQL----------
---SDP-DLSKMC------------PQTQSTPADPT-------TLSQPLSEKE----GK-
------------------------QTQ------PPSL--------HLKKMSEDLEIN---
-------KKYDKECAPG----------HPEVPSVKVHGREPLTGDTTGKNRGSNKSSSEL
--QHTAGDVLENICPAEDP--DDCR-R-------THFKVE---EISKKQGS---------
--------LK-CVPDSCIKE-AKDSEK--EAWSPREPVVTPESERPPPEG----------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------A---------G-LL------LLKDGRLLTK-
---------------------MDQAE-RRLTKREAKEKHK---TKTQVNE----------
-------------------------------------------------------M-EEA
SHGSE----------------------PRAP---AS--GWG--SGSPLKLCDT----THS
DERLIEL---KNRH-------------------CELLTRKPGKMGTM-------------
-----------REQTEIT---KIKTWSQHKEGA-WD-KL--CALRFPLKQDEKQEN-AEF
MF-QQKKPQ----LQREKEQ------------------CGGSVQWTQ-Y-SEIGTVIAEL
KALEKDLR-QFHN-----------------------------------------------
---------------LKESWET---TYYK------YLHMVVKLQFIEQELIAIKTEQKKC
GHLL-KN----------Q-KNLEEEVLHLK--------SWIRESEIQAR-----------
----DQNN-----------------------------------IENLRDTN--D----AA
MISQIDLRIKNMETQLAMRGTQQ--H----------------------------------
---------------------LPGGGMPKHKHH-H----------AEEGSLAQPV-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
-----------------------------

------------------MRRVFGLGS-RG------------------------------
--------------------------------------------------------QAPS
GPAGV-----------------QGS----------------------------SGGPRPR
VGVRAVGK-----LHK---------------AASTGDA----------------------
AR---VQHLLILGK-SG--IN-DRDKK------------------YRTAL----------
----------HFAC--AYGHPEVVTLLVERKCDIDA--CDSENSTALIK-----------
-AVQCHQEECVTILL-EHGANPNVADAS----GN--TALHYAV-YCENSSIAAKLLSHHA
NTEAKNKD-D---LTPHL------LAVREKRQQVAE-LLIKKEAN--------IHAV---
-DKPER-------FSNK-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------PG--------------S----D--SWPTSDD---------
--------DDYNFDNKN-------------------VPKINITELWAAAQQSRKN----Q
TKYGIGEA------------------GNRTLLKDNISVSK--------------------
---------------------N-------------------KDVV---------------
------------------------------------------------------------
-----------------------------ETLPK--------------------------
----------------------------------TSINVQNFSQSS--FISPSPDT----
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------KEEATESEIRKEE---------
---NGTCVIK----NASQE---------------QTNDS-------------LTQVDAGR
KKY----KSDMMFALGLGED-D-ESPWDSESL-SENLPQKSVD---------------HL
SGPADKKGKHRGNR---Q------VED----------------------------VIYIP
SCINGSRNFKIAKLEDTGNV--------------GIPVAHKESAEECLHLKPA----IER
-KSTVLNK-----------------------------AVAME------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------DLWT----------------
--------------------------------------------C---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------NS
E-----EPEEEQKRLDG-------------CENSHEQV---------EGNRKQI------
---------------------------HNDMEVS---ENEFSGIVTTT------------
----NGDDGFIQ---------QRKNGKND----NQQFPIKENEEH---------------
---------DSSGPALPVRE-IKKNEN--EQWSSTESMISPVFEEANSL-----------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------PGGLLQVKGSYSLHD-
-------------------SNENEE---RSIKKTSNENSK---VKEQIDGVN--------
------------------------------------------------------DF-DDL
SQSSETASEDCELL--YPKYENILLLFEQLR---ME--CKD--SVSVLKIWDA----VHS
YKTSIEL---KKDH-------------------DELLMGKIKKLENK-------------
--VRRLQ----KELTEIK---EVKSQLEHEKLH-REGEL--GKLRFALQQEEEKRRNVHQ
CY-EKIKEQ----LRKKEEQ------------------YYQEVEAKQQLEISLRTLDIEL
KTVRNKLH-QVLEEQNDTLRQLSQEQNSRMLKDAIL-----ANHLCE--QKEIETAP---
-EKISPEISV-----SHE--ED---LLHK------NHRLQDENARLRLEIDAIKNQNQAK
EKKYLEDIELAHKKNDDLQRTVKLNEE------------TIFQCNGQLNSL-T------V
ENTMLNSK-----------------------------------LENEKQIK---------
--ERLEAETESYCSRLAAAVQDY--DESQTSKRDVE----LAFQRARDEWFRLQDKLNFD
LSNLKDNNEMLS--------------------------Q-QLSKAERKFNS--LEIELHH
AR-DALREKTSV-LEQ--VQRDL--KQTQCQMKE-----IKHMYQN-EQGKV------NK
YMGKQESIEERLSQLQSENALLRQQLDDAHNKV---DFKEKTVINIQD----QFHGIVKT
LQGES-KKQSLILEDRNKELIDEC-NHLKERIYQYEKEKAEK EG--VVRQLQQELADT--
--LKKQ------SMSEASLEISSLYRINLEDETRDLKKNLSQIRSQ-LEEEQNRHTQAAQ
C-----------------------------------AEKLQQHLQKLELENSRLKVKVKK
QAGKTEQLQ----KHLLST-----------------------------------------
------------------------------NLSEGDKE-QLKKL---TELTESLEFT-LD
QEKKKNGELQKELIGFKKL-----LKMTK--------------TKLNE------QENG--
--DF---HADLKSNE--LDIPINMLIHKVDDLAAKLETASSKCLHLDKN-----------
-NDFL--QQELLSMKNIEKKCETLEKNEKKLEQEVVKMRSH---LEK-SVVEHSQIEQY-
KQEIEERARRDL-VEKLRQVNL---FLQTQAA-SQENLQQ-LRET-NNASM RSQMELRIR
DLESEV-SKMKI-QE------ETNKVQLEKYR----QHYLEELNTRKSLS-SKLNKANER
LEEANTKLLVEKQQ---NRSLLS------TVSTRPVLECPCFGNLNHSVVFQRSFLPREN
LVV-PLLNPQPSNNS-MESYLTKMRHELEKSITREVREA-TAE-----FES-----G---
--------------------SFKVSPIRSA---------NKS------SQDLMSETSQEY
LEILRRR--YMI------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

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-------------------------------------------------------KMKVD
MSGLQAKNEILS--------------------------E-KLSNAESKINS--LQIQLHN
TR-DALGRESWI-LER--VQRDL--SQTQCQKKE-----TEQMYQI-EQSKL------KK
YIAKQESVEERLSQLQSENTLLRQQLDDAHKKA---NSQEKTISTIQD----QFHSAAKN
LRAES-EKQILSLQEKNKELMDEY-NHLKERMDQCEKDKAGRKV--VMREFHQEWTDL--
--LKQ-------------------------------------------------------
--QP--------------------------------------------------------
------------------------------------------------------------
--------------------------------T---S--EATSR----CH---IN-L---
------------------------------------------------------------
-------------DETQDSKKKLGQIRSEVDLTEAQETVPSRCLHLDAE-----------
-NEVLQLQQTLFSMKAIQKQCETLQKNKKQLKQEVVNLKSY---MER-NMLEHGEAEQH-
KLLIEERARKET-EEKLNEAVL---TLQKQAAVSQEQLAQ-LRED-NTTSIKTQMELTIK
DLESEI-SRIKTSQADC------NKTELERYK----ELYLEEVKVRESLS-NELSRTNEM
IAEVSTQLTVEKEQTR-SRSLFT------AYTTRPVLESPCIGNLNDSEGLNRKHIPRKK
RSA---------LKS-VESYLLKVSYVFSFGVQI--------------------------
-------------------------SDIILICYLVK------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

MEEEINY-------GAQTMN--I------P------------------------------
---------------------------------------------------------RRR
RWYT--------------RL--WHSCLDLRC--------------MH--PQKKKKYPLYL
IGYDPIGP-----LQR---------------AASVGDL----------------------
DT---TEKLIHSS-QHH--VD-ESDRR------------------KRTSL----------
----------HYAC--AHNHPDVVTLLLENNSSINI--RDDEGCTPLIK-----------
-ATQRDNVDCASVLL-THNADPNLIDFS----GN--TALHHAI-SRGNLRIVKMLLEHNV
DIEAKTEY-G---LTPLQ------LATFEQKPEMVE-FLAAKCAK--------SSVT---
-PSWSP-------SP-TVSPCP--SSTS--PLSSL-------------------------
--GL-HVC-PNP--------GTSS------LSE-DRKSS---SA------RRI-------
-KL---------------------------------------------------------
STGSSAQRTEVKHVRFN-EEVLYF------KEERPLSCEARPPGQLKSILKNT------V
--------------------------------------QYNTVNEKITRRTSLW------
------CSKGEDVR------------------YTSCIKVKCFSVKSSFL-----------
------------------------------------------------------------
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-----------------------------

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--MAS---------------RGGEKRGGSEGSPKPTVSAMRKTPSV--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------GSVRSQEDQL-
----------SLSYQGDRWSSDSS----CDSAGSDSE--------H-------------V
EGAL--------------------------------------------------DQP---
-----QHDVCLEDPCELHRA--------------ARSGD-------VP-----GVERVLA
PGD-----------------------------------PGVNKRD-RKESLWHLIPECKM
EQSPESLPQNNNPDWHPTNLTVSDKTCQKSKILSVDDQCPSVSPSMPENQSAAKELGQMN
LTEQEKM----------N---------------------VSGNGSLH--DLC-QSQLPE-
----------------------NKESK---------------E------AEQDLELTSEE
E---QERLKGHENKQPQ----KMSQEPEMAKDCDRED------------------IPVYS
ILPHAQKSEEMWIEQGKLEWKNKLKL-----------VTNELKQRFGE------------
------IRETYKIP----------------------------------------------
----VCPEEEPLLDNSMRKTNVKDIPFNLTN-N-------------------------IP
GCVEEDASEVSVS-VFETFPEQNEPSLKSIIH---------PYSHPYSGSLEHACQSSSK
LHLHENKLDCDSDNKPGIEHIFSMDEN-FSNDAGTKKAR-NPEEVTVEMKE-----D---
QEF-DLQMTKNMNQNSDCC-----------------------------------------
---------------------------STNNYKSLKPKL-E--NL-SSLPPDSDRTSEVY
LHEELQ---QDMQKPKTEVDRVEEMF-----LALKKENVQLQKEVEEEVEKQ---RSNST
ELSG-----------NPAHGAAAG------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------NNDDGL-NQQ-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------FPRKK-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------KKGH-DRPADKTSNEKNK---VKNQVH-----------
---------------------------------------------------PEADF-ADS
VGPSETASEDCELS--HSTYENFLLLIEQLG---ME--CKD--SVSLSRIQDT----FCF
YEHLLKL---KNND-------------------YEQLTVKIKQTENM-------------
--VSVLQ----KELSETK---KTELQLKLQKIE-LEKQL--YSLRLALKQEKEEKGNAVM
LY-NKYSER----LRLKEEE------------------CGKEVEMKQRLKWTLRRLVKEL
KTVRNNLD-LVVQERNDVQKQLSEEQNARILQDQIL-----TS---K--QKELE------
--IAQKKINSE-ISHRHKKEKD---LLHE------NCMLQEEIALLRLEIDTVNNQNQQK
EKKYFEDIEVVKEKNDNLQKIIKLNEEKLT--------KTILQYSGQLNDL-TA------
ENKILNSE-----------------------------------LENKKQNQ---------
--ERLEIEMESYRCRLAAALRDC--DESQT-SRDPK----LDFQRTRQEWVHLQDKKKVD
MSDLQAKTEILS--------------------------E-KLSNAESKISS--LQIQLHN
TR-DAVERKSLI-LER--LQRDL--SQTHCEKKE-----IEQMYQT-EQRKL------KK
YIAKQESVEERLSQLQNENTLLPQQLDDAHKKA---NSQEKTISTIQD----QFHAFAKN
LQAES-EKKILSLQEKNKELMDEY-NHLQERMHQCEKEKAR RKV----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------DLIEAQETAPLRCLHLDAE-----------
-NEVLQLQQTLFSMKAIRKQCETLQKNKKQLKREVVNLKSY---MER-NMLECVEAEQH-
KLLIEEKAKKEI-AEKLNEAIL---TLQKQAAVSQEQLAQ-LRED-NTTSV KTQMELTIK
NLESEI-SRINTSSADF------NKTELERYK----ELYLEEVKVRESLS-NELNRTNEK
IAEVSAQLTVEKELTR---SPFA------ACSTRPILEPPCAGNLNDSEDLNRKHVPRKK
KSA---------PES-MESYLLKVSYLFSFGVHIFS--------PSSFLLC-----M---
----------------------SQ------------------------------------
--LVLAE--VMILIV---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------MKKIF---SKKG------------------------------
--------------------------------------------------------ESPL
GSFA----------------RRRRSSAGGGG----------------EPGEGAYSQPGYH
VRDRDLGK-----IHK---------------AASAGNV----------------------
AK---VQQILLLRK-NG--LN-DRDKM------------------NRTAL----------
----------HLAC--ASGHPEVVTLLVDRKCQLNV--CDNENRTALMK-----------
-AVQCQEEECASILL-EHGADPNLADVH----GN--TALHYAV-YNEDIPLATKLLLYDA
NIEAKNKD-D---LTPLL------LAVNGKKQQMVE-FLIKKKAN--------VNAV---
-DKLES-------SH-QLISEY--KEER--IPKNSSQNSNSGKTSDSELL----------
------LT-KSC--------TVAQ------A-----------------------------
-----GVQ----QHDLSSL-QPP-------------------------------------
LPG---------------------------------------------------------
---------------------------------------------------FT-------
-------Q----------------------------------------------------
FSCLCLPSSCDHRLSG--KPGV--------------D----D--SWPTSDD---------
--------EDLNFDTKN-------------------VPKPSLAKLMTASQQSRKIV-SLE
ATYGIVRT------------------GSRTLFEDRDSDSQ--------------------
---------------------D-------------------EVVC---------------
------------------------------------------------------------
-----------------------------ESLPT--------------------------
----------------------------------TSVKVQGFSHPT--CQSPDPLP-KPS
HKS---------------------------------------------------------
----------------------------------------LANP----------------
-----------------------------------GLIKEGPKKPAIGKKE---------
---NGIDIIE----SAPLE--------------QTNNDN-------------LTYVDEVH
KNN----RSDMMSALGLGQEEDIESPWDSESI-SENFPQKYVD---------------PL
AGAADRKEKNMGNE---Q------AE----------------------------------
-----------------------------------------ESPERYLHLKPT----IEM
-KDSVPNK-----------------------------AGGTK------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------DV------------------
---------------------------------------------QTSK-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------AA
EHDLEVASEEEQER-KE-------------SENNQPQVE--------EERKKHR------
---------------------------NSEMEVS---ANIHDGATDDD------------
-----EDDGLIQ---------ERRSGETD----HQQFPRKENKEY---------------
---------AGSGPALQMKE-VKR--------TSKESVNSPVFEKASLL-----------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------TGGLLQV---------
--------------------------------------------KNQIQSVD--------
------------------------------------------------------DV-DDL
TQSSETASEDCELP--HCSYKNFMLLIEQLG---ME--YKD--SVSLLKIQDA----ALS
CERLLEL---KKNH-------------------CELLTVKIKKMEDK-------------
--VNVLQ----KELSETK---EIKSQLEHQKVE-WEREL--CSLRFSLNQEEEKRRNADM
LY-EKIREQ----LRRKEEQ------------------YRKEVEVKQQLELSLQTLEMEL
RTVKSNLN-QVVQERNDTQRQLSREQNARMLQDGIL-----TNHLSK--QKEIEMTQ---
-RKMNSEVFIF-PLVIFKYVKD---LLHK------NSMLQEEIAMLRLEIDTIKNQNQEK
EKKCFEDLEIVKEKNEDLQKTIKQNEETLT--------QTISQYNGRLSVL-T------A
ENAMLNSK-----------------------------------LENEKQSK---------
--ERLEAEVESYRSRLAAAIHDR--DQSETSKRDLE----IAFQRARDEWSRLQDKMNFD
ASNLKDNNEILS--------------------------Q-QLFKTESKLNS--LEIELHH
TR-DALREKTLG-LER--VQKDL--SQTQCRMKE-----MEQKYQN-EQVKV------NK
YIGKQESVEERLSQLQSENMLLRQQLDDAHNKA---DNKEKTVINIQD----QFHAIVQK
LQAES-EKQSLLLEERNKELISEC-NHLKERQYQYENEKAER EV--VVRQLQQELADT--
--LKKQ------SMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQ-LQEAQDQHTEAVR
C-----------------------------------AEKMQDHKQNYN----------QK
QMEKIEELQ----KNLLNA-----------------------------------------
------------------------------NLSEDEKE-QLKKL---TELKQSLECN-LD
QEMKKNVELEREITG----------------------------KKLNE------YENG--
--EF-SFHGDLKSSQFEMDIQINKLKHKIDDLTAELETAGSKCLHLDTK-----------
-NQVL--QQELLSMKTIQKKCEKLQKNKKKLEQEVINLRSH---IER-NMVELGQVKQY-
KQEIEERARQEI-VEKLKEVNL---FLQAQAA-SQENLEQ-LREN-NFASM KSQMELRIK
DLESEL-SKIKTSQE------DFNKTELEKYK----QLYLEELKVRKSLS-NKLNKTNER
LAEVSTKLLVEKQQ---SRSLFT------TLTTRPVMEPPCVGNLNNSLYHNRKLIPREN
LVI-SSSKPRTSNNS-VENYLSKMQQELEKNITRELKEA-AAE-----LES-----G---
--------------------S-IASPLGST---------DES----NPNQDLVLKASREY
VQILKKN--YMI------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------MKRLSAAAVKGE------------------------------
--------------------------------------------------------TGPE
RPSP-------------------------------------------FSQLVYTNNDSYV
IHHGDLRK-----IHK---------------AASQGQA----------------------
WK---LERM-MKKTTMDLN---IRDAK------------------KRTAL----------
----------HWAC--ANGHAEVVTLLVDRKCQLDV--LDGENRTPLMK-----------
-ALQCQREACANILI-DSGADPNIVDVY----GN--TAVHYAV-YSENLSVVVKLLSCGA
DIEVKNKA-G---HTPLL------LAIRKRSEQIVE-FLLTKNAN--------ANAV---
-DKFKC-------TA-LMLAVC--HGSS--EIVGMVLQQN--------------------
---------VDI--------CAED------TCG-MTAER---YA----------------
--------------------VAC-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------G--------------
----------FN--LI--H-------------------------QQLLEYKQ--------
-----------K------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--ISKNSQ-------------------------------------------NS-------
------------------------------------------------------------
-------------------------------------------------NP--AEGTSEG
TPEEA-------------------------------------------------------
-------------ASLAER-------------------------------------I-PD
KAK---------------------------------------------------------
------------------------------------------------------------
-------------------CSV--ERTPDE------------------------------
------------------------------------------------------------
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-----------------------------

MVA-----EVGSMPAASSVKKPFGFRRKMGKWG---------------------------
----------CHCLPCCRGSGKSNLGASADQDDSARKTRRSKMAKWCCHCLPCCRGSRKS
NVGASGDQDDSAMKTLRSKMAKW-CCHCLPCRRGSGKSNVGAWEEYDD---SAFMEPRYH
VRREDLDK-----LHR---------------AAWWGKV----------------------
PR---KDLIVMLRD-TD--VN-KTDKQK------------------RTAL----------
----------HLAS--ANGNSEVVKLLLDRQCQLNV--LDNKNRTALTK-----------
-AVQCQEDECALMLL-EHGTDPNIPDEY----GN--TALHYAI-YNEDKLMAKALLLHGA
AIESKNK-----------------------------------------------------
------------------------------------------------------------
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-----------------------------

MGGKYSRGEERRPLGFPGFSALCCCQKTNR------------------------------
---------------------------------------------------------EET
PLGF--------------CDIKARRSNL---------------------SFGREDPAYLD
MAYFPDND-----LHM---------------AACAGDL----------------------
PF---VRLYFTLG-KYE--VN-HRDRE------------------NRNAM----------
----------HFAC--FYGHLELVIYLWRRGCEINV--CDNHNITPLMK-----------
-AVQSWEDKIVCFLL-EHHANLHIKDSM----GN--TALHYAV-YSGNLATAARLLQYGA
DIEERTKD-N---LTPLL------LALRENRLKMAQ-FLVRMEAS--------VHAV---
-DSQRR-------NS-LMYAVR--CDSP--VMVNL-------------------------
--IL-QQG-VDI--------NLKD------LFG-WTALR---YA-IE---GDR---D---
--VRTMLLELRKRNRAFQS-----------------------------SEN-SSIRLIN-
KADAEVTSPTANEKVIEMQDPFTT------NEASVE------------------K-TQT-
---------RRPAE------------------------SELE---VFSLE----------
----------EE-----------------------------ISYKETINNLQ--------
--------QNPGQRSA--KTDA-----------ATE--------NRSP------------
------------------------------------------------------------
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-----------------------------

------------------MKKLFPFREKRK------------------------------
--------------------------------------------------------TDDS
-------------------HSHSSDL-----SI----------SLASTM-PSLSTGGGYH
LRDKPLKK-----LHK---------------AASVGNV----------------------
QK---LKDYLERKK-YD--VN-GRDKR------------------SRTPL----------
----------HFAC--ANGYTNIVSLLIENQCKINV--QDSENRTPLIK-----------
-AAECQQESCATLLL-HHGADPNLGDIY----GN--TALHYAV-YGQNISLANKLLDYKA
NLEAKNKD-G---YTPLL------LAVAENNENMVK-FLLKKGAD--------VNAS---
-DKNHR-------TA-IMIALI--VEPT--NSVKL-------------------------
--LL-QQD-ADL--------ACED------IYG-FTAEE---YA-SF---NGF---TM--
--YHQLIANNEKKKKT--EQTAH-------------------------------------
------------------------------------------------------------
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-----------------------------

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-------------------------NWASAAL-SLNNETCQRA-RH-----------LKV
DGQCALVSHSMIKN------------------------------------QSASTE----
------------------------------------------------------------
-------------------------------------------FG-----QKTVIDKMKM
KT---VAVF-PVGNYSLHQLCKSE----------------------LPGNRGSKDLS---
--------------RELDLE-------------------MITEEE----------QEKL-
--DE--------------------------------------------------------
-----------------------------------DENN----------------HAQVC
KISGVVLYEKMCIKQGKLEWKDKLTP-----------IINELKWF--T------------
------EIKEYQIT----------------------------------------------
----ISPEEDQLHDNPKEGANQKEISPNLTN-N-------------------------IP
HWEGKDAFGVPVSLVFQAFPVSKM------------------------FFHGLACRSSSK
LFFPENKVDFENY-QLDIEHVFMKIEDGFYNDTENKKVG-EL-VVIFEVK------D---
QEI-DMQMSQNMRQGQNNCS----------------------------------------
----------------------------TSDNKSMESGL-E--NG-NSSPPNSHSASEVY
VNEELE---KDMQRFKNEIDVFQVEF-----LALEKHSVKLPLKVE-EEKKH---KSSEV
EVSE-----------NICDAA---------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------D-------QR----------
--KIGG------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------NSNQEFPAMQ-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------NEGS---DRPARKTPYEKKK---VKELINYVN--------
------------------------------------------------------EL-DDL
TQSSETVSEDGDVL--YSRNSTLQV-E--------PHNVGYKDSVSLLKIQDT----ILS
HERLVDF---QRSQR----------------SHCELLRGEFYRMKSK-------------
--VHGLQ----KELSETK---EVKSQLEHQKVE-WEREKSFKFFRFTLKQEEENRRNAYV
LG-NFSRSP----TMKSSQEELGKVVFVIQIHLSRAVRWSHTMASSKNLVYLYRADA---
------------------IFKCSHIYES-----FIL-----SLWVCYSSER---------
-----SLFSSE-LLENCEETKD---LLHK------KHMLQEEIAMLRLEIDALKNQHREK
EENYFEDIEILKVKNDDLQKAIKLNEETLT--------KTISHYTGQLNAL-TA------
ENTMINSK-----------------------------------LENKKESK---------
--K-TGTEVKSYCSRLAAALH----D---TSKRDLE----LAFQRARDEWLCLQDKMKYD
VANLKDNSEMLS--------------------------Q-QLSTVESIFNK--LKIKLHH
TR-DDLREKTLM-LER--VQRDL--SQSECQKQE-----IEH-YQN-EQGKV------NT
CLGKQESLEERLSQLQSENMLLRQQLGNAQNRA---NSKVKTVISIQD----QFQQIVRK
LQAKY-EKQGLLLEKRNNELIKEY-NHLKERMYWYENEKAEGKK--TADFPAE-LET---
----------------AS------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------SKYLHLV---
--AK-NQVFQQELLSMKRI---------------QKKCKKLEKKKKKLEQ----------
-----------------------------------------EVV-NLRS-----------
-H------------------------------------------IEM-NMIEHSQVEQY-
QQEIERNKKKSTYFCRLICSSV---ICLNSLS-LYSTFWIYTELSDYTQAEFQQIELRIK
DLESEL-SKMKSLQEDS------NKAELEKYK----QLNQVECEVRKSLE-DKLDKTHER
LAVISTKLEVKKEK---KRSLLS------SLSMRPVLEPPCVGNFNNPLVLNGNLTPRAK
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------MRKLFSFGRRLG------------------------------
--------------------------------------------------------QALL
SS----------------------------------------------RD-KEYAGPGYH
IRDWELRK-----IHR---------------AAIKGDA----------------------
AE---VERCLR-RF-RD--VD-ARDRK------------------DRTVL----------
----------HFAC--VHGHIEVVTLLLNRTPLMKV--CIKMNLSH--------------
---LNITKACAIILL-ERGANPNIKDIY----GN--TALHYAM-YNKGTSLAEKLLSHRA
NIEALNEE-G---NTPLL------FAINSRRQQMVE-FLLKNQAN--------IHAV---
-DNYRR-------TA-LMLAVQ--HNSS--SIVSL-------------------------
--LL-QQN-VNI--------FSQD------MFG-QTAED---YA-VC---CDL---RR--
--YVLI------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-----------------------------

MVA-----EVCSKPAASAMKKPFGLRSK--------------------------------
------------------------------------------------------------
-------------------MGKW-CCHCFPCCRGSSKSNMDTWADYDD---SAFTEPRY-
VHREDLGK-----LHR---------------AAWWGKV----------------------
PR---DDLIVMLRS-TD--GN-KKDKKK------------------RTAL----------
----------HLTS--ASGNSEVVKLLLGRRCELNA--FDSKKRTALIK-----------
-AVQCQEDECVLMLL-EHGTDPNLPDVY----GS--TALHYAV-YNEDKLLAKALLLYGA
DIEAKNKC-G---LTPLL------LGVHGQKQQMVK-FLVKKKAN--------LKAL---
-DKFVR-------AA-LILAVC--CGS-A-SIVSL-------------------------
--LF-EQD-IDV--------FSQD------VSG-KTATD---YA-VS---SHH---D---
------------------------------------------------------------
------------------------------------------------------------
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-----------------------------

-------------------MKLFGFGSRRG------------------------------
--------------------------------------------------------QTAQ
GS----------------------------------------------ID-HVYTGSGYR
IRDSELQK-----IHR---------------AAVKGDA----------------------
AE---VERCLARRS-GD--LD-ALDKQ------------------HRTAL----------
----------HLAG--ASGHVKVVTLLVSRKCQIDI--CNKENRTPLIQ-----------
-AVHCQEEACAVILL-EHGANPNLKDIY----GN--TALHYAV-YSESTSLAEKLLSHGA
NIEALDKD-N---NTPLL------FAIICKKEKMVE-FLLKNKAS--------THAV---
-DRLRR-------SV-LMFAVH--YDSP--GIVNI-------------------------
--LL-KQN-INV--------FTQD------MWG--DAED---YA-IS---CHL---TK--
--IQQQILEHKKKILKKDKPDVG-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------S--------------
----------SD--ES--A-------------------------VSIFHEL---------
------------------------------------------------------------
--------------------------------------------C---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------V----------------------------------------------------
------------DSLPPSD-----------------------------------------
------------------------------------------------------------
----------------------------------------------------------NE
-DLTVATK--------------------------------------------Q-------
------------------------------------------------------------
-------------------------------------------------RV--PEKVSEP
LPGPS-------------------------------------------------------
-------------HEKGNR-------------------------------------IVNG
KGE---------------------------------------------------------
------------------------------------------------------------
-------------------GPPAKHPSLKPS-T---------------------------
---------------------------------------------------EMEDPAVKG
------------------------------------------------------------
----------------------------AV-------QRKNVQTL---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------RAEQALRVASEEEQERLER--SEKKQPQVKEGNNTNKSEKIQL--SEN---
------------------------------------------------------------
------------ICDST-------------------------------------------
--------------------------------------------SA--------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------AAADR-LTQQRKIGKTYPQQFPKK-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------L-----------------------------------------------------
-------------------------------------KE--EHDRCTLKQENEEKTNVNM
LY-KKNREE----LERKEKQ------------------YKKEVEAKQ-LEPTVQSLEMKP
KTARNTP-----------------------------------------------------
---------NQ-DFHNHEEMK---DLMDE------NCILKTDIAILRQEICTMKNDNLEK
ENKYLKYIKIVREINAELEKSVKLNEEMLT--------KTAFQYQQELNDL-K------A
ENARLNSK-----------------------------------LMKGKESK---------
--ERLEADIEPYQSRLAAAISKH--NESVKTERNLK----LALERTQDVSE--QVKISSD
ISEVKDENEFLT--------------------------E-QLSKMQIKFNT--LKDKFQK
TR-DTLRKKSLA-LET--VQNNL--SQTQQQIKE-----MKEMYQN-AEAKV------SK
STGKWNYVEKRTCQLQRENLRLEKQ-LEGVHQK---EHHEEIVINIQR----GFI-----
---ES-GRKDLLLEEKNKQLMNEY-NHLKESLFQCEKKKKERVV--VLRQLQQEVADS--
--LKKL------TMLESPLEGT-SCHINLDE-TQASEKKLFQVESQ-PEEKNEELR----
------------------------------------------------------------
-------------K----------------------------------------------
-------------------------------------------L---SVLVSSLEYN-VN
QIRKKNHELEEEATGYKKL-----LEMTI--------------NMLSV------FGNE--
--DF-GCHGDLKTDQLKMDILIKKL--NRSLMIL----RHRRKLYLQNV-----------
-SIWL------KTIKFFNRSYYL-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------------------------------------------------
------------------------------------------------------------
----------------------MRKLFSFGR--------------RL-----GQAGRGYH
IGDWELRK-----IHR---------------AAIKGDA----------------------
AE---VERCLTRR-FRD--LD-ARDRR------------------DRTVL----------
----------HLAS--AHGHVEVVTLLLGRRCLIDI--CDRLNRTSLMK-----------
-AVHCQEEACAIILL-EHGANPNIKDIY----SN--TALYYAV-YNKGTSLAEKLLSHHA
NIKALNKV-Q---INQLS------F--QNNLICLVKIFHITIKIL---------------
-------------------------------ILFI-------------------------
--TF-IMH-ISL--------YHQS------GVQ-WHDLR---SL-QP---PPP---RFKQ
FSCLSLPRSWDNR----------HMQPHPDNFCIFNRDGSFILTKHMDLSAQHNLKVAS-
E---------------EKQERLER------SENKQPQDSQSYGKKKDVMYGNYMLKRDIA
MLKQELYAIKNDSLRKEEEYIHEIKSITEINANFEKSVRLNE--EMITKTMAQY------
------SQELND-----------------------------LKAEN--------SRLNSK
LEK---EKHNKGRLEA--EVK-------------------SL--HSSLATAI--NEYN--
------------------------------------------------------------
-------------EILERKDLELVLQRADDVYGQE-----K-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------MGSDIPQLT-------------------------------------
------------------------------------------------------------
-----------------------------------DKNEL-----------LTEQLSKAR
EKFSTLKAKLHETRDALREKA---LALESV------------------------QMDLKQ
AQHQIK----EMKQMHPNE----EAKESQSTG-TQNSLEDRICQQ----ELENLLLEQQL
EDAHKEGDNEEIVINIQGGCLENGKEDLLLEEKNMELMNEYNYLKEKLSYVKEEGE----
----GEVKQLASHL-----------------KKF-------------PMSESP----LEG
-TSHCHINLDETWASKKKLYFKSGIQTQAFWLLCRTASQTIPWNTWLVSSI-ILLMQF--
DDL-----MAKKEA----------------------------------------------
--------------------------------VSSKCVNLAKDNEVLHQELLSMRKVQEK
CEKLEKDKKMLEEVL-NLKTHMKKDMV---------------------EL-GKVQEYKSE
L------DERAM------------------------------------------------
--------QAIEKLE-EIHLQEQAEY------------EKQLEQLNKDNM---ASLKKKE
LTVKDVECKFSKMKTAYEEEAFAVALKANNSMSEKIMKSDKKIAVI--------ST----
---KLLIEKEWMKYFL-STLPMRPDPELPCV-E---------------------------
-------------------------NLNSI----------GLNRKYIPK M-PLRIPTSN-
---PQTSNNCKNSLTE--------MEPDC---------------VEQIITE---TKKRPP
SV------GRAL-------ILALGPGG-V------SDEDLGA------------------
-PQFHSASPLDTPRTTRTTPSWPCHQAQS---------GSMITKTQVQRQLPCTVDQQNM
--------------E---E-ARAAGSQLPRSPRWHLGL-----------------GRSFL
KGKLETLMS-LE---ERVNVASEQ-------------------PWQP-AASSHP------
--TCLSATNVLQMEPHRGN----------EQQAQER---GVRC-------LWG------S
IPCIRASTALWASWMPRGRPQAIL-RRTLWCLCS-------------SAEREWESKI---
------------DGFKCF---------TKK----------MDNR----------------
A----LSSTSQPMSEA-----------FHTVS------EDLDPAM-NLLV----------
LSQGHR-T------NILDII-----------HIHKE-------ALTKVTESRQQVAEGKI
EVQRLMMSESQEQDFFGHFG----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
-----------------------------

------------------MRKLFSFGRRLG------------------------------
--------------------------------------------------------QALL
SS----------------------------------------------RD-KEYAGPGYH
IRDWELRK-----IHR---------------AAIKGDA----------------------
AE---VERCL-RRF-RD--VD-ARDRK------------------DRTVL----------
----------HLAC--AHGCVEVVTLLLSRSCQIDI--CDRLNRTPLMK-----------
-AVHCQEEACAIILL-EHGANPNIKDIY----GN--TALHYAM-YNKGTSLAEKLLSHRA
NIEALNEE-G---NTPLL------FAINSRRQQMVE-FLLKNQAN--------IHAV---
-DNFRR-------TA-LMLAVQ--HSSS--SIVSL-------------------------
--LL-QQN-INI--------FSQD------MFG-QTAED---YA-VC---CDL---RS--
--IQQQIL---E------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------H--------------
------------------------------------------------------------
-------------K-----------------------------NK-------M-------
-----------------------------LK----------NHLR---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------N----------------------------------------------------
------------DNQETAA-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------VK-------------------------------------------PA-------
------------------------------------------------------------
-------------------------------------------------NL--K------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------K
------------------------------------------------------------
----------------------------RK-------EGAK-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------EHNLKVASEEKQERLER--SGNKQPQDS---------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------QSYGRKKD---VMYG------NYMLKRDIAMLKQELYTIKNDSLRK
EKEYIQEIKSITEMNANFEKSVRLNDEMIT--------KTTAQYSQQLNEL-K------A
ENTRLNSK-----------------------------------LEKEKHSK---------
--ERLEAEVESLHSSLATAINEY--NEILER-KDLE----LVLWRADYVSV--HEKMDSN
ISQLTDKNELLT--------------------------K-QLSKARVKFNT--LEGKLHE
TR-DALREKTLA-LES--VQMDL--KQAQYRLKE-----MKQMHPN-EEAKE------SQ
SFGKQNSLEERIHQQELENLLLEQQ-VKDAYKE---GNNKEIVINIQE----DCL-----
---EN-GKEDLT-EEKNMELMNEY-NYLKEKLFQYEKEEAEG EV--IVRRLQEELADH--
--LNKF------SMSESPLEGTSHCHINLDD-TRASKKKLFQVGSQ-PEEKHEEFR----
------------------------------------------------------------
-------------K----------------------------------------------
-------------------------------------------L---FELISSLYYN-VD
QIRKKNHKLEEETTGYKKC-----LEMTI--------------NMLNV------FGNE--
--DF-SCHGDLNTDQLKMDILFKKLKQKFDDLTAEKEAVSSKCVNLAKD-----------
-NQVL--QQEFLSMRKIQEKCEKLEEDKKMLEEEVLTLKTH---MEN-NMVELGKVQDY-
KSELDERTTQII-EKLEEI------HLQEQAK-YEKQLEQ-LNKD-NTASL-NKKELTLT
DVECKF-SEMKTAYEE-----V--ITELAEYK----EAFAVALKANNSMS-KNLMKSNKK
IAVISTKLLMEKER---MKYFLS------TLPVRPDPELSCIENLNSIG-LNRKDISKTP
VRI-PASNPQTSNNC--KNSLTEVEPDCVEQIIRETKKT-FAV-----LGT---------
CSHLLSSLESTGP-----------E-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TAL----------
----------HLAC--ASGHQEVVTLLAERKCELDI--RDGRGKTALIM-----------
-AVQCQEEKCANILL-EHGADPKTADVN----GN--TALHYAA-HHGMISIAEKLLSLNV
NVDVKSKV-L--------------------------------------------------
------------------------------------------------------------
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-----------------------------

------------------MRKIVWWASKKS------------------------------
--------------------------------------------------------SV--
-----------------------------------------------GCENGIEAQFGYH
IRRKELRK-----LHK---------------AASEGDV----------------------
AR---VQHLCLLKK-SS--VN-DRDRN------------------NRTAL----------
----------HLAC--ASGHSEVVMLLLERKCMINV--TDNDNMTPLMK-----------
-AVQSHEEKCARILL-NHGADPNIIDEN----GN--TALHYAA-YCENVGIAKQLLLRSA
DIEVRNKD-G---FTPLL------LAIYENGEEIAE-FLIKKGAN--------IHAV---
-DKIKR-------TA-LMLAAQ--YRST--RIVRL-------------------------
--LL-EKG-IDA--------SCLN------MYG-WPAEK---FA-LV---TFN---LY--
--LRRVKTFI---------LSGP-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------N--------------
----------IV--LF--Q-------------------------ST--------------
------------------------------------------------------------
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-----------------------------

------------------------------------------------------------
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------------------------------------------------------------
--------------------PWYHIQDR--------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------GLRKIHKA
AS----------------------VG---NVAKVHQVLLLGENGL-NDRD----------
--KRN-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------RICCLFIF---------------------
------------KPNKHIMV-------------------LKILGFCCL------LT----
----------------------LDDFKGNNSGV-SWVSAP-----KKEKKKNLKVHFSQK
KSFSLCKFMLCMLQIVLYIS--ASA--LSLKYAIDTV--AKDDL---TPLLLGIHERRGQ
M-EFLVKKAQKGRRKKGSFDRKDKTALMLAVKYESANVVRLLLQQGADIFSQDVFGWTVE
EYAVISGFNIFL--LLISEYKEKRSK-ASPENSNPEEKKK---LIV--GDLTS-------
--KTVLSEKKSVSLIWPLKPY---------------------------------------
--------------------------IGSLCKSEKK--ML--SEYDVHFIYSHSIADWTS
YERYPRI---PHVSVYIYAQKLNFFKEVIHIYISFSIYRELYILRERENFLSVLLSAYST
DCVNGIVSFSVSLLEF-----DSDSSLNHEQT----MEKESLFFRFVLSHQVYSSLGKQE
LL-------------QSI---NGIFSS--------AVRTFSENKLF---LGSADTLAVTL
C--YGKLGERDAEIGNEKLFNHHKRNKGGFLSRVLLERHLVQSFHCV--NVEV-------
-SLSFQRKSWN-VSDGWEEAQD---LLRK------NHT-------LRLEIDALKRQHREK
EENYSEDMGILKGKNDDLQKAIKLSEETLT--------KTVSHCTRQLNAL-TA------
EKRMLTFK-----------------------------------LENEKESK---------
--QRLETEVKPYRSRLAAASRDH--DQGQTSQRDLE----LALQRARDEWLCLQDKMKSD
MANLNDVAETFS--------------------------Q-QPSIVESRLNK--LKIKLQH
MR-DDLREKTSM-LER--VQRDK----PECQKQE-----IEHMYQN-EHAKV------NT
YLEKQKTKGE----IISAPVLLRQQLDDAQSRA---DSREKTVMSVQD----QLQQITRE
LQAEH-EQRGL-MEERNKQLIKEC-NHL-KRMCQYKKEKAEREV--SIQKE---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

-----------------MSNLVHG----IK------------------------------
---------------------------------------------------------EKT
PMGF--------------CDVPRKNLFDFLR--------------DM-----KSISVPNK
PRYKPLKK-----IHQ---------------AASEGDV----------------------
KR---LQKMIRLG-KHS--VH-DRDFK------------------QRTAL----------
----------HFAC--AYGKVEAVSVLLRNNCDIDA--VDRNSITPLMK-----------
-AVQNWTYGCVHTLL-KHGADPNHMDKN----GN--TSLHYAV-SEDNQMLAKYLLKYSA
DMEQKNKD-G---FTPLL------LALKENKIEMAK-FLVKKGAN--------IHVF---
-DEMKR-------NT-LLYAIR--WDAK--DMVSL-------------------------
--LL-KEG-IDF--------SFKD------VFG-WTALR---YA-IE---GTS---K---
-GSRKILMDYDEKLRIKNKDGSLEYKNSEEN---------------------SLA-----
------------------------------------------------------------
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-----------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------SRTPL----------
----------HLAC--INGHADVVQFLVEKKCKLNP--CDRLDKSPLIK-----------
-AVEHQHRDCAAILL-EHGANHDHRAVN----GN--TALHFAV-MASSKSLVKLLLEHGA
DIDAKNKW-G---YTPLT------LAIIENHEEMVK-FLLQKGAD--------VNAL---
-DKVYR------------------------------------------------------
------------------------------------------------------------
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-----------------------------

---------------------INVAD----------------------------------
--------------------------------------------------------RCED
RKP---------------------------K-------------------ENINPLSEYH
VRHRDLGK-----IHK---------------AALTGNV----------------------
AE---VQRILLLN-KNG--LN-EPDKC------------------ERTAL----------
----------HLAC--ASDHPEVVRLLVERKCQLDL--LDGDQKTALIK-----------
-AIQCGNEECASILL-EHGADPNVTDYR----GN--AALHYAA-AHDNVSIAEKLLSHNA
PIEAKNKS-Y---LTPLL------LAVLENKQQMVE-FLIRKGAN--------IHAV---
-DRLQR-------NR-LMLAMG--E--K--EYKYK-------------------------
------------------------------------------------------------
------------------MSQNN-----NPVDMNV---------------EEDHVRSSSR
KS----NI----------------------------------------------------
----------------DDS----WPT----SDDDFIGLD---------------------
---------TKEASNPN-------------------------------------------
----------------------LRKLAIAVRKYM--------------------------
------------------------------------------------------------
-------------ENI-EEKHDIERTEGRAMFEGSD------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------SATPVEKVGE-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------TLPQTVITLLTPS--------------------------------------
-------------------LHAI---SDFT---------------------------KEG
AT--------IPTIR------------KTEN------GISVVE----------S------
-----S------------------------------------------------------
-----------------------------------------------------------P
NEQRTND-----------------------------------------------------
------------------------------------------------------------
-----------L-------TCDGDS-----------------KIC---------------
------T----------------HAAGSTLGLG----------EEEDTESPWDSES----
------------------VTDSPSSQ----------------------------------
------------------------------------------------------------
---CAGSS-----------------------SG---------------------------
------------------------------------------------------------
------------------------------------------------------------
----------AAREKG-----------RHGVDGRWQDVFYMPFY----------------
------------------------------------------------------------
---------------------------------------------R--------------
-------------------------------SGSRSFN----------------------
----------------------------------------------VTKLENTRNVGMP-
-------------------------------VAHRSPKMTPHLMPTLEE-----------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------RD-S----KAGGVEDVQTPRQA
ELDLKMT------PEEEQERLDGSAE-RQPKADERRK---------KQS-----------
------------------------------------------------------------
---SNEMS--------------------TSE---IP--CGG--AAAPA-GEDG----HGV
CQQSAKA---------------------------D-------------------------
--------------------------------------------SLLIP-----------
----------------TKEH---------------------------------EEHDGST
KTTSKEK-----------------------------------------------------
---------KE-ISDSCDREKD---LLDR------NRKLESEVATLRLKMKTIKNHILKK
EKKYVEDIQILKEKNDDLQKTIKQNEATIG--------QTIACYSGRLVVL-S------T
ENAMLNSQ-----------------------------------LESEKKNK---------
--ERLESEVESYRARLAAAIQEH--DQT--SKRDLE----LAFERAREEWFHLKEKMNLD
ASNLKENNERLS--------------------------Q-QLSETKSKLNS--LQIELLH
AR-EALRERTLA-LEQ--VDRCL--SQTQCQMKK-----IELKYTN-KQCKL------NK
YSGKQEWKEENLCQLQREVAMRQ-------------------------------------
--------------------------------------------------LQELAEA---
---PKT------QSMGASLEVISHNHINLEDETQDLKKGLSQI-GI-LQEEKNQPVEAIK
C-----------------------------------SEKTQDHIPKLEKEISKLKVILKD
QASKIEELQ----KTLSRT-----------------------------------------
------------------------------SSSKDEKE-QLK-F---TILKQSLEYK-LD
QEIKKNCELEKEKIGLKKL-----LHMTQ--------------RNFSE------FGNR--
--ES-NFQSDARFSQFQMDIQLDMLKYKMDDFTTRVETASAELEHIDAK-----------
-NQIL--LQELESM--TIQQYVKLETGKLNLEQEIINLKSH---MEI-SMVKSVQEEQD-
KR--------EI-EGRARQIEEKLKEVHAQAT-AQENLEQ-IREY-NHASVRSQMQSRIY
DLEFEL-VKIRASQEN-----T--NKAELEKY----KQYLEKSQVKKSLS-DEK--TDEK
LAIVRAKHLMDKQQ---KRFLLN------SLITRPVLESPVGNPDNSL-VYSRNLISRET
SVV-SSISRAXXXXX--XXXXXXTQLELLRNI----------------------------
--------SG--ERSRVATEFASLSRA-------------SPQRTD-ENTDLLLRASE-Y
GQI-AKK--YMI------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------MKKIFNFGSKKG------------------------------
--------------------------------------------------------QSPS
RSFA----------------VPRRDCG----------------------VPESDTSAGYL
LRDKELGK-----LHK---------------AASVGDV----------------------
AK---VQQLLLLGK-HD--VN-DLDKV------------------KRTPL----------
----------HLAC--AKGYPDVVSLLVQRKCKLNL--CDNDNRTPLIK-----------
-AVQCQQEECATILL-EHGADPNLVDSN----NN--TALHYAA-SGQNKAIAAQLLKHKG
DIEAKNKE-G---YTPLL------LAVTENNHDIVD-FFLKNGAN--------VNAS---
-DKSKS-------HR-QLINQY--EIQK--IFKYGGNNTYN--D----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------L
IVEESSAEESLSRLSD--KPGA--------------D----D--SWPTTDD---------
--------EELDFTTKK-------------------LPKSNITKIINVSQQIRK---SID
EKSSTVNT------------------EHRTFLGHHQSDSE--------------------
---------------------K-------------------EDMT---------------
------------------------------------------------------------
-----------------------------DSLPK--------------------------
----------------------------------PSSQAQCSPHPA--HPSLRSFSKSSH
MMS---------------------------------------------------------
-----------------------------------------TLL----------------
-----------------------------------AINKEDSTDSEEEEKE---------
---DGILVDN----DTG-K--------------QTP-HE-------------TPSIPNEH
STS----ARDMMSALGLEEEDDAESPWDSEVF-LLRFPYLLIT---------------PI
ASTNQTIKNSISME---Q------LED----------------------------VPYIP
SFLNESRNFKMDKLTDTRSI--------------RMPVGSLDHPQRNPIFKPIQ-STLEM
-KDSFTNQ-----------------------------EVEKK------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------DFSK----------------
--------------------------------------------NAVLR-----------
------------------------------------------------------------
------------------------------------------------------------
---------------KQC------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
E-----SPLEKEDDKEG-------------KKKNPCQVE--------EEKKKHQ------
---------------------------HNEMETL---EGKNGDKL---------------
--IRSNNIGLIC---------ERHQGKTG----YPFFPNKENEEH---------------
---------CSNDFATNRKN-VKKPQN--NKWIPKDPGMTLSSEKVNSS-----------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------SGILLHSCDDSSLSE-
-------------------TDNYEL---RPAKKTLNEKNK---DKVQVD-AD--------
------------------------------------------------------DL-DDL
TQSSDTATEDYDLP--PSNYKNIMLLIEQLS---VD--CKD--SIHLLKIQDA----VLK
YERSVEL---KKAR-------------------CTQLKRKVKSLENK-------------
--ITGLQ----EELSETR---KMKSQLEHQKVE-WDREL--YRLRFTLKQEKEKQLSTEM
LF-EKTREQ----LRRKEEQ------------------YSKEVELKQQLEFTLRTLDLEL
RTVKSNFK-QVEEERNDAQRQLSREQSARVLQDGIL-----NNYLWK--QKEIEAAA---
-SKMIQSS--E-VPDSHEKEKC---LLHE------NQSLLDEVAKLKLELDTIKIKDQEK
EDRYTEENEVLKEKNDELQKELKLKEEALR--------ETIFQYSGQVNVL-T------T
ENTMLSSK-----------------------------------LDNEKQNR---------
--DKLETEVESYRSRLNSAILDH--ERSQTSKLDLE----NIFQRERDEWLHLQDK----
---LRDNNGVLS--------------------------Q-ELSKAESKANR--LENELYQ
VC-DSLREKTLI-LES--TQREL--NQTQNKAKE-----LENKNQM-DKEKL------DR
YIIKQESIQERLAQIQSENMLLRQQLEDAQNKG---VIKEKVVNDVQV----QFSDLFNK
LRADT-EKQVLLVEERNKELINEC-NHLREQMCKYENEKAEREG--TVRKLQQELADS--
--LKKQ------SMTEASLEVTSRYRNDLEDKKKQLQKEVDQIKSK-LQESQERHIQSQR
S-----------------------------------TNELEDHIQKLEIENARLEATVKQ
QVGKIENIQ----KNILDS-----------------------------------------
------------------------------TKLDTERE-KLKKL---IELKQSLENR-LE
QEMKRNDELQKDVSGFKKL-----LKTTK--------------KKLRE------YEKG--
--EV-ISQEVLKQTHFDEDRQINRLKNKNEDLTQQLEATSSKCIQLESI-----------
-NRNL--REELLSMKSLQKKCDRLERNKRELEEEVVDLKHH---LEI-TKLEHSQVEQY-
KREIEERANQEI-VEKLKEVNL---FLQTQAA-TQDYLEQ-SREN-SNASIRNQMENRIR
DLEAEL-SKMKNSHQ------DSTKAELEIYR----QLYSEELKIRESLS-NKLDRTNER
LAELSSRLLNEKQK---SRILIN------SFTTSPVLEPPHVGDLHTTMVLNRRLIPRGN
LLY-STGNTVSSTNS-MEAYLTKMRQELDKSISRELDEA-NAE-----FES-----R---
--------------------SCWAFPVGST---------DESTRMPNLNQDPVSRATQEY
LEVLKKN--YML------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------MKKIFGFGSKKGES-PLG------------------------
------------------------------------------------------S-----
------------------SISPGRDG-----------------------GHRINFQPGYR
IRDKDLGK-----IHK---------------AAIVGNV----------------------
AK---VQQILLLGK-NG--LN-DRDKM------------------NRTAL----------
----------HLAC--ANGHSAVVTLLLERKCLLNL--CDSENR-------TA-LMK-AV
-ECQ-EEE-CATLLL-EHG-AD-PNVMD-VS-GNT-AL-HYA--VF-SF-FK-IY-----
-----NCK-----LN-SV---------HQ-AL-LL--WK-QL-QG---------------
--------------Q-C-R-G-----G---------------------------------
--------------------GCMC------VH----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------RKGKALFSN--KPGV-------------------D--SWPTSDDED-------
----------LDLETKN-----VLK--------------PNLTKLMSA------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------S--QQSKRNIE---AKCGIVRA
ESTTLSEDNN----------SDGEVEDVVETVPEPSPGVRGFSHPA--FPSPEP-LPQPL
-KSL--------------------------------------------------------
------------------------------------------------------------
--------------------------------AGLGLTKEGATKPEIVDKE---------
---SDTDIVE----RAPQEQI--------------NHDLLS-------------SVDGTH
KNN----RSDMMSALGLGEEEDIESPWDSESI-SED---------L-------------L
SGAA--------------------------------------------------GQ----
------------------------------------------------------------
-------------------------------------------RG-----KNTLNGQV--
ED---VSYI------PS---CMIGSRNFKMAK------L--E------------------
------------------------------------------------------------
------------------------------------------------------------
----EPRHVGIPV---------------AHMGM---------------------------
----KKSE----------------------------------------------------
------------------------------------------------------------
------YCYEL----L------FYK-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
----CVSQ-------------LIK----FLS-----VKLS--------------------
------------------------------------------------------------
-----------------------------------------LKV-EEEKKKH---KSSEV
QVSD-----------DVCDAA---------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------DESEL-SQQR----------
--KSGG------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------NSIQEFAAMGSEGS---------------
--------D--SDPGMHRKE-VKKKDTS--KWTPEECVIAPIF-----------EK----
----------------------TDSLTGGLL-----------------------------
-----------------------------------HV--NDDS----I------------
------------------------------------------------------------
----------------LSEVDQDD---DRPAKKTSNENNK---VKEQINSVD--------
------------------------------------------------------DL-DDL
TQSSETASEDGELL--Y--YKNSMLLIEQLG---TA--CK--DSVSLLKIRDT----ILS
YERLVEL---KKSH-------------------CELLRGKIKKMESK-------------
--VRGLQ----KELSETK---QVTSQLEHQKVE-WEREL--GSLRFTLKQEEEQRRNADM
LY-EKMREQ----LRRKEDQ------------------YSKEVEMKQQLELTVRALEMEL
KTVRNDLD-QVTEERNDTQKQLSRERSARILQDGIL-----ANHLAK--QKEIE------
--MANKEVNSE-VSVSCEEAKD---LLRK------NHMLQDEIAMLRLEIDAVKIQNQEK
EKKYFEDLEIVKGKNDDLQKAIKLSEETLT--------KTISQYTGQLSAL-TA------
ENTMLNSK-----------------------------------LENEKESK---------
--QRLETEVESYRSRLAAASHDH--DQCQTSKRDLE----LAFQRARDKWFHLQDQMKSD
MANLRDNSETLS--------------------------Q-QLSRAESKFNN--LEIKLHH
TR-DSLREKTLM-LER--VQRDL--SQAECQKQE-----IEHMYQN-EQGKV------NK
YIGKQESLEERLSQLQSENMLLRQQLDDAQNKA---DSKEKTVISIQD----QFQQIVRK
LHSES-EKQGLMLEERNKELIKEC-NHLKERMHQYENEKGER EV--TVRQLQQELADT--
--LKKQ------SMSEASLEVLSRYRANLEVEAQDLKKKLCQLTSQ-LQEAQDQLTEAVR
CAEK-----------------------------------TQDHVFKNNFLK---------
----------------NFFSKSE-------------------------------------
-------------------------------DE---KE-QLKKY---IELKQSLENS-LD
QEKKKNSELEKEITGFKK-----LLKMSR--------------RKLNE------YENGE-
---L-SFHGDLKTSQTEMDIQINMLKHKIDDLTAELETASSKRLHLDAK-----------
-NQVL--REELLSMKGMQKKCEKLEKNKKKLEQEVVNLRSH---IEM-NMIERSQVEQY-
KREIEERARQDL-VEKLKEVNL---FLQIQAA-SQENLEQ-LQEK-NNASI RSQMELRIK
DLESEL-SKVKTLQEES------HKAELEKYK----QLYLVELEVRKSLE-GKLDKTHER
LAVISTKLEVEKEQ---NKSLLS------TLTTRPVLEPPCVGNFNNPLVLNGNLTPRAN
VGF-STSIPRPSNNS-METYLTKMRQELDRSITRELREA-AAE-----FES-----E---
--------------------SYGLSPLGAT---------DGS----NLSQDLLLKTSQEY
VQILKKK--YMI------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------M
KALQCQREACANILID-SGADLNVVDMY----GN--TALHYAV-YSENLSMVAKLLSHGA
VIEVQNKA-S---LTPLL------LAIMKRSERIVE-FLLTKNAN--------ANVV---
-NEFKC-------TA-LMLAIC--DGSS--EIVGMLLQQN--------------------
---------VDI--------FAED------MCG-MTAEH---YA-AA---CGV---NV--
--IHQQ------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------LLKHIRKLSK--NPQN------------------TNPEGTPAGTTDE-------
---------AAPLAE-----------RTPDMAESLVERPPDEAAPLVEGTS---------
--------------------------DKIQCLGKATSGKFEQSSEE--TPRKIMRPTKET
SEKS-EWPAKERPRKITWEEKETSVKTECVAGVTPNKTE---DLEKGTS-KIITCPTK--
------------------ETSIKAST----------------NAQMFQAGSKQ-------
----KDNEE----NSLDFENFLENLLQNDECLPKATHQKEFSKISGKLEESSDKDGLLQP
TGGMKAANPNKAL---E-----LKDRETVK-----AVDVSSVEPISSLFGKMTTENSQSP
KVEE--------------------------------------------------------
------------------------------------------------------------
--------------------------------DFNLATKEGATKTVTGQQK---------
---YIIGIIE----QAPQDQT--------------NKMPIS-------------------
---------------ELGQKEDTKSTSVPEII-SVNDTQNYVC----------------L
PEATY-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

MGA-----EVSSKPAASTMKKPFGLSSK--------------------------------
------------------------------------------------------------
-------------------MGKW-CCHCFPSCRGSSKNNVDSEGDHDD---IAFL-----
------EP-----STL---------------QF---------------------------
-----------AKT-SS--H------SH------------------RTAL----------
----------HLAC----GNSEVVKLLLDRKCQLHV--FDSKKRTALIK-----------
-AVQC-----AILLL-RHGIDPNLPDVY----GN--TALHYAV-YSEDRLMAKTLLLYNA
DIESKNKG-G---LTPLL------LGVHGQKQQMVE-FLIKKKAN--------LNAL---
-DRFGR-------TA-LILAVR--CGS-A-SMVSL-------------------------
--LL-QQN-IDV--------FSQD------VSG-WTAED---YA-VS---SHH---NI--
--ICQLLSDYKEKQMPKKCSEN--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------SNPEQ-----------
---------DLQLTSEE------------------ESQ------------SLK-------
--------------------------------GGENS-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------QPE--------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------ASTTI--LNI-----------
---KLPLKVE--------------------------------------------------
---------EEMQRHG--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----SNN------------------------------VGIS------------------
------------------------------------------------------------
-----------------------------------------E-------NL---------
--------------------------------------------------TGG-------
------------------------------------AAA---------------------
---G---------NG---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------D-DGLI---------------------------P----
----Q-------------------------------------------------RKSRKP
----------------------------------------ENQ-----------------
--QFPSTE------------------------------------------------SE--
------------------E-----------------------------------------
----------------------------------------------------YH------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------MRKLFSFGRRL-------------------------------
------------------------------------------------------------
----------------------------------------------------EYTGRGYH
IADWELRK-----IHR---------------AAIKGDA----------------------
AE---VERCLTRRF-RD--LD-ARDRK------------------DRTLL----------
----------HLAC--AHGHVEVVTLLLGRRCQIDV--CDRLSRTPLMK-----------
-AIHCQEEACAIILL-EHDASPNIKDIY----GN--TAVHYAV-YNTGTSLAEKLLSHRA
NIEALKKE-G---NTPLL------FAINSGRQHMVE-FLLKNQAN--------VHAV---
-DNFRR-------TA-LMLAVQ--HSSS--NIISL-------------------------
--LL-QQN-INI--------FSQD------MFG-QTAED---YA-VC---CDL---RS--
--IQQQIL---E------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------H--------------
------------------------------------------------------------
-------------K-----------------------------NK-------I-------
-----------------------------LK----------NHLR---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------N----------------------------------------------------
------------DNQEIAA-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------MK-------------------------------------------PA-------
------------------------------------------------------------
-------------------------------------------------NL--K------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------K
------------------------------------------------------------
----------------------------RK-------EGAKA------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------EHDLKVASEEKQERLER--SENKQPQDS---------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------QSYGKKTD---VMHG------NYMLKRDIAMLKEELYPIKNDSLRK
EKEYIHEIKSITEINANFEKSVRLHEEMIT--------KTMAQYSQELNDL-K------A
ENSRLNSK-----------------------------------LEKEKHNK---------
--QRLETEVESLHSSLATAINEH--NEILER-KDLE----LVLRRADDISE--QEKMGAN
ISQLTGKNELLT--------------------------K-QLSKARVKFST--LKAKLHE
TR-DALREKTLA-LES--VQLDL--KQAQHQIKE-----MKQMHPN-EEAKE------SQ
STGKQNSLEDRIRQEELKNLLLEQQ-LGDAH---------KEVINIQG----GSV-----
---VN-GKEYLLLEEKNTELMNEC-NYLKEKLFQYEKEEAEG EV--IVRQLQEELADH--
--LKKF------SMSESPLEVTSHCHINLDE-TRTSKKKLFQVESQ-PEEKHEEFR----
------------------------------------------------------------
-------------K----------------------------------------------
-------------------------------------------L---FELISSLDYN-VD
QIRKKNHELEEEATGYKKC-----LEMTI--------------NMLNV------FGNE--
--DF-SCHGDLNTDQLKMDILFKRLKQ---------------------------------
------------------KKCEKLEKDKKMLEEEVLNLKTH---MEK-DIVELGKEQEY-
KSEQVEMAMQAL-EKLEEI------HLQAQAE-YEKQLEQ-LNKD-NMASL-K EKELTLK
DVECKF-SKMKTAYEE-----V--TTELEEYK----EALAVTLKANNSMS-EKIMKSDKK
IAVISTKLLMQKER---VKYSLS------TLPTRPDPELPCVENLNSTG-LNRKYIPQMP
VRI-PTSDPQTSNNC--KISLTEVSYVTIS------------L-----LGF---------
ISLI--------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MVD-FFLKNGAN--------VNAC---
-DNSKR-------TA-LMIAVS--TEPT--SIVNLLLQFD--------------------
---------IDL--------SLQD------NYG-WTAEE---YA-LV---SGF---PV--
--HRELILQYGQRQL-NQLTSAKI---SSPDRASD-------------------TVFTLG
GPA------LDKEDIKEE-----------------------KKAQGLGGPGNR---KA--
----------------------------EIQE-----------------SPVQ-------
------------------------------------TS---------------RTRISGK
VVEESSPEDSISRFSD--KPGP------------------DD--SWPTSDEEE-------
---------LD-FSTQK-----LPK--------------PNLKKLINAS-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------QQIRTN-GANDEKGNTVKT
EHRAFHG----------HNQSDSEKEDVTDSLPKPSSQAQYSLHPV--HPLPDTFSILVQ
KMSS--------------------------------------------------------
------------------------------------------------------------
--------------------------------P-LGINKEELIDTEEEEKK---------
---DGA-LFD----NENREQI--------------HHETSN------ILSELQAPITSQK
CTV----RRDMLSALGLEDEEDTESPWDSECT-SESLPKESVI--H-------------V
SAATNQAMKESISR------------------------------------GSLEDYP---
--------------------------------------------KKHPNLQ--PTQPTLV
MKDSFTNQETE---------------------------KGVMEKE-----KSDLLEEFGL
DD---ADDIDDVSNWDSPSTSQKNVTYRNYKDLNFDGNYPCKSMPLTKNQSGSTEFGELP
LKEDETAAAVQETGPEPRFSVVILVDKPGSQKQSEPQLLLEKEESKK--DLT-QESEFEG
SSEES------QENFDKSDQEEEEIII-----------------ETANTAE-QTA---SK
K---QLKPLSFPVLHLK----TAL---LEES-N---SED----------------MHLDA
DQNWEEKYEKMWVEKDKMEVKKNFKI-----------ITTELKQVFGE------------
------ISTKNKIA----------------------------------------------
----HQSTEELQEDESKPLQEV---SSDFTN-N-------------------------SS
DNMGIEKSGDSLDIGFQSFPEEREDNPENDIF-----------QHLNLTFEEKVHQSPFN
LCSKSSHQLCQNENNSETVYTCNVNEEDVTCDAEIVRIA-NSKKITNEMKE-----D---
GAF-DMQMAVSLDRNTINLR----PNSEHLLESSGLGSHFGDQLTGSHDVKPIIQDKEPT
ITTTTKFNEKTELNENL-----FQNLVDSDN---STNEL-R--HW-KYSLPSSDKISKMY
LDKELK---QDVQRFKNELGMLKVEF-----LALEKEKTQLQKEVEEEKKKH---LHNEM
ETLE-----------ERNINSVLEDTEVKGQ--------------NSSIMKV--------
--------------------V---------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------PNGYL-ILKI----------
---MNF-----P------------------------------------------------
------------------------------------------P-----------------
------------------------------------------------------------
-------------------------------SNDSA------------------------
-------------MNLKYVK-----KPPSDKWISEDPGITSSC-----------EK----
----------------------VNSLTSI-------------------------------
---------------------------------LLQV--HDDSS----------------
------------------------------------------------------------
----------------LSEDLHEG---SNLKKGGGGNSHA---NGELMD-AD--------
------------------------------------------------------DL-DDL
TQSSDTATLDDDLP---PSYKTIILLIEQLS---ID--CK--DSISLLKIQDA----VLT
YERSLEL---KKGR-------------------CTLLAEKVKSLENK-------------
--ITGLQ----EELSETR---EVKSQLEHQKVE-WDREL--CSLRFTLKQEEEKRLNSEM
LF-KKISEQ----LRRKEKQ------------------YIKEVEIKEQLELTLRSLHLEL
KAVRNNLK-QVEEERNETQRKLSHEQSARALQDGIL-----SNHFW------KQKEA---
-FEANVSKMNQ-SCEVPDSHEK---DLQK------NHTLQDEIAMLKLELDAVKIKNQEK
ENRYTEENEVLKEKNDELQKELKLNEEALT--------KTVLQYSGQLNVL-TT------
ENAMLNSK-----------------------------------LKNEKQNR---------
--DRVEIEIESYRSRLTSAILDH--ERSQTSKLDLE----HTFQRERDEWLRLQDKLNYD
LSSLKDNNGVLS--------------------------Q-QLSKAESKANS--LENELHL
VR-DSLREKTLI-LES--TQRDL--NQAQYQAKE-----LEHTNQI-EKEKL------NK
YVVKQESMQERFAQIQSENMLLRQQLEDAQNKG---IIKEKVVSDVQV----QFSDLFNK
LRADS-EKQVLMVEERNKELINEC-NHLKEQMCKYENEKAEREV--TVRQLQQELADS--
--LKKQ------SMSEASLEVTSRYRNDLEDKKQQLQKEIDQIKSK-LQESEERHLQSKR
STNE-----------------------------------LEDHIQKLEIENARLEATVKQ
QMNKIEQIQ----QNMLDA-----------------------------------------
------------------------------TSLDNERE-KLKKL---IELKQSLE-SRLD
QEIKRNGELQKDISGFKRL-----LKATK--------------KKLKD------YEKGN-
---L-DYQGRMKHACSEEDGQINRLKNKIDELTQQLEDASSKCIHLESM-----------
-NRGL--QEELFSLKTVQKKCDRLEKNKKQLEEEIANLKHH---LEI-YTLERSQVEQY-
KREIEERARQEI-VEKLKEVNL---FLQTQAA-SQENLEQ-LREN-NNASIRNQMEHRIR
DLESEL-SKLKNSQQDS------TKAELEIYR----QLYSEELKTRKSLS-NKLERTNER
LAEVSAELLNEKQR---SKTLIT------SFTASPVLEPPHIGNLNNSLVLNRGLIPRGN
IVY-STGNTVSSRNR-AEAYFTKMQQELEKNIARELNEA-TGE-----LES-----G---
--------------------SCWPSPIGST---------DESSRMSNVNQDPVSRATQEY
IEVLKKN--YML------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------MKKTFGFRSKTE------------------------------
--------------------------------------------------------VLPL
GSSI--------------SPGRD--------R----------------GHHRTSFQPGYH
IRDRDLKK-----IHK---------------AASVGNV----------------------
AK---VQQVLLLRK-NG--LN-DRDKK------------------NRTAL----------
----------HLAC--ANGHSEVVALLLERKCQLNL--GDSENKTALIK-----------
-AIECQEEECATLLL-EHGANPNVTDVN----GN--TALHYAV-FCQNVSLAAKLLSYDA
NIEAKNED-D---LTPLL------LGISERKQQMVE-FLVKKEAD--------IHAV---
-DKMQS-------RG-SNLQGC--RLEH--SENPF-KLSR--------------------
--PL-SNV-GRDGSRNRFSNKP-G------VDS-WPTSDDDILG-SE---TKK---EP--
--KPNLAKLMKAFQQSKRNQAEC-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------G--------------
----------IV--RR--E-------------------------STTLSEN---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----NNS-------------------------------------------DS-------
------------------------------------------------------------
-------------------------------------------------EI--EDVV-ET
LPKPS-------------------------------------------------------
-------------PGVQGF-------------------------------------S-HP
A-----------------------------------------------------------
------------------------------------------------------------
--------------------FPRPDPLPKPL-K---------------------------
---------------------------------------------------TLAGLGLA-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-----------------------------

------------------MRKLFSFGRRLG------------------------------
--------------------------------------------------------QALL
DS----------------------------------------------MD-QEYAGRGYH
IRDWELRK-----IHR---------------AAIKGDA----------------------
AE---VEHCLTRRF-RD--LD-ARDRK------------------DRTVL----------
----------HLTC--AHGRVEVVTLLLSRRCQINI--CDRLNRTPLMK-----------
-AVHCQEEACAIILL-EHGANPNIKDIY----SN--TALHYAV-YNKGTSLAEKLLFHHA
NIETLNEE-G---NTPLL------FAINSRRQQIVE-FLLKNQAN--------VHAV---
-DNFRR-------TA-LMLAVQ--HNSS--SIVSL-------------------------
--LL-QQN-INI--------FSQD------LFG-QTAED---YA-VC---YNF---RS--
--IQQQIL---E------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------H--------------
------------------------------------------------------------
-------------K-----------------------------NK-------I-------
-----------------------------LK----------NHL----------------
------------------------------------------------------------
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-----------------------------

----------------------------TE------------------------------
--------------------------------------------------------EDSP
DWQT--------------RKNP-----------------------LQHLWGDGFSCAEYK
IKPCHLER-----IHR---------------AAVYGKL----------------------
KK---LDTILITEN--C--ID-DKDRK------------------NRTAL----------
----------HLAC--ATGQYQVVELLVLNNCQLNL--VDSECRTPLVK-----------
-AIQLKHMSCATFLL-ENGANPNIVDYY----GR--TALHYAV-YNEDTAIIERLLSHGA
DIERSSKE-E---PSPLL------LAVSQGKLKMVE-FLLKKNAN--------VNAL---
-DSLKR-------SA-LTLAVR--LEKT--DIVTLL------------------------
---L-QHD-VDV--------FSQD------VYG-KTAEN---YA-AD---DKN---EI--
--ILKLISEYKEEKKSKGLSINS-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------N--------------
----------P-------------------------------------------------
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-----------------------------

------------------MRKLFSFGRRLG------------------------------
--------------------------------------------------------QALL
SS----------------------------------------------MD-QEYAGPGYD
IRDWELRK-----IHR---------------AAIKGDA----------------------
AE---VERCLTRRF-RD--LD-ARDRK------------------DRTVL----------
----------HLAC--AHGRVEVVTLLLHRRCQIDI--CDRLNRTPLMK-----------
-AVHGQEEACAILLL-ECGANPNIKDIY----GN--TALHYAV-YNKGTSLAERLLSHHA
NIEALNKE-G---NTPLL------FAINSRRQHMVE-FLLKNQAN--------IHAV---
-DNFKR-------TA-LILAVQ--HNLS--SIVTL-------------------------
--LL-QQN-IRI--------SSQD------MFG-QTAED---YA-FC---CDL---RR--
--YVLIL---KDRLILN-------------------------------------------
------------------------------------------------------------
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-----------------------------

------------------MKKLF------K------------------------------
---------------------------------------------------------GYS
PW----------------------GFLSFRH--------------------ENQEPPWYL
TGYTPVKK-----IHK---------------AASMGDI----------------------
TQ---VQRMLEFG-DVD--VN-ITDRK------------------KRTAL----------
----------HYAC--AHGQSEMVALLLWYDCNIEA--RDRDESTALIK-----------
-ATQRQHEECVKILL-ENGADPNAIDAY----QN--AALHYTV-YNNTVSIAARLLAFNA
DTEVKTKH-G---YTPLI------LAVLENKQEMVE-LLLQSDAN--------INAL---
-DNYKR-------SA-LIHAMR--AQSK--DMISL-------------------------
--LL-QQG-ADA--------SLMD------VYG-ATARS---HA-VF---ETF---Q--V
SGH---------------------------------------------------------
HPCIP-VKTPTQEM----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-----------------------------

------------MGVGGSFLGT--------------------------------------
------------------------------------------------------------
-------------------CGGCMAPWRENR----------------G--KDGFSNPGYR
VRQKDLGM-----IHK---------------AAIAGDV----------------------
NK---VQESILLRL-ND--VN-NRDKK------------------NRTAL----------
----------HLAC--AHGHPGVVADLVARKCQLNL--TDSENRTALIK-----------
-AVQCQEEVCASILL-EHGADPNVRDMY----GN--TALHYAI-DNENISMAGKLLAYGA
DIEAKSQD-E---YTSLL------LAINRKKEQMVT-FLLKKKPD--------LTAI---
-DNFGR-------TAL-ILAAC--NGS-------------------TG----------VV
FQLL-QHN-VDV--------CCRD------ISG-WTAED---YA-IA---YNF---Q---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
----------------------------------------AIRR--------------LI
SEYK--------------------------------------------------------
------------------------------------------------------------
-----ANK-------------------------------RR-------------------
------------------------------------------------------------
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------------------------------------------------------------
---------------------------------------------K---R----LQNRNP
EQDLEMTSEGEQESLEG-------------CESSQPQVE--------EKMKKCR------
---------------------------NKKMEVS---RNVHADDSDNY------------
---NDDVDELTH---------KIKNRKPD----NHQFPRKENDKF---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------DRLARKTSNEKSK---VKSQIYFKD--------
------------------------------------------------------DL-NDV
TGSSIKTSEDDDLP--YSDDKNFMLRIEQHG---ME--CKD--FVSLLKIKNA----IAA
CERSIEH---KKCN-------------------CEQLKVKFQKMKNK-------------
--ISMLQ----KELSETD---ETKSQLEHQNLE-CKQKL--CNFSCILQEEEEKRRKAEE
LY-EKDTEE----LKIMEEQ------------------YRTQTEVKKQLQLTLKSLEVEL
KTVRSNSN-ESS------------------------------------------------
--------------HTHEKERD---LWQE------NHLMRDEIARLRLEIDTIKYQNQET
EKKYFKDIEIIKENNEDLEKTLKLNEETLT--------KTITRYSKELSAL-M------D
ENTVLNLE-----------------------------------LEKEKQST---------
--QRLKTEMESYPCRLAAALHDH--DQCLSAKRDRQ----LAFQSTVNEWCHLQENINSH
I-------EILS--------------------------Q-QLSKIESTSSG--LETELHY
ER-EDLKEKTLA-IEH--MQGVL--SRTQCRLKD-----IEHMYQN-DQPIF------EK
YVRKQQSVEDGLFQLQSRNLLYQQQCNDADKKA---DNQEKTIINIQA----KCEDTVEK
LQAEC-RK----LEENNKELMKEC-TLLKERQCQYEKEKEEGEV--VMRQLQREVGDT--
--LNKQ------SLSEAMLEISSQCHHNLEDETRDSKKKLDQLRSQ-VCMKLSMSTVTL-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------MKKIF------K------------------------------
---------------------------------------------------------GHS
PW----------------------GFLSFRH------------------A-ENQEPPRYL
TGYMPVKR-----IHK---------------AASVGDI----------------------
PQ---VQKMLEFG-DID--VN-VTDRK------------------KRTAL----------
----------HYAC--AHGQSEMVSLLLWYDCNIEA--RDREESTALIK-----------
-ATQRQHEICVKILL-ENGADSNAVDIH----QN--TSLHYTV-YNKDTSIAAKLLAFNA
DTEIKTKN-G---YTPLI------LAVLENKQEMVE-LLLQAAAN--------INAL---
-DNCKR-------SA-LIHAVR--TQSK--NMISL-------------------------
--LL-QQG-ANA--------SLVD------IYG-ATAQS---YA-VF---ETF---Q--V
LSQ---------------------------------------------------------
GPGPR-PELTTKEARHN-FD----------TKDDLVPCSPPFKEDNKRMEENRDAVDK--
------------------------------------------------------------
--------------------------------------LGSFAHRPNNSEPIEVEDEPSL
--------------NT--KPPV-------------------V--QSPMLTES--NLWA--
-----------GYP--A------------------DWPEPIKFSRQPAVYNPT-------
-------------EW--REDMESRSV----PLES------K-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------QQAAV---LPGKE-------------------------------------
------------------------------------------------------------
-----------------------------------ASV----QTQ---Q-QQARAFKAPG
AKDPDLPSRE-NAKDELV----------SL------------------------LAPLEE
KKPQMK----EFP----------------------------------------------V
TEAAKFQTDVKL---EREGVL-------EFEEKGLEICQDSN------------------
------------------------------------------------------------
--------LEA---------------------------------AESTESYSILRFAK--
PD------VGDPE-----------------------------------------------
----------------P-------------------------------------TARKDE
FKSETKDEDRLERHPLAPRASQHQA-----------------------------------
------KQTSPPPVQLQER--SQ--GPEMDTA------------------------SDED
DTSGLSKSAKGQMLGGKLTLGENPE---------------------GKETVQCVINKPTQ
KG--DEFYED---------------VNAN-------------------------------
---VYLKEERPP-DVS-GKTHLTSDPTTLAY-NMFDCGDR--------------------
--DV---SAALVSVALQTSPRQEEGGLGNAFPSPSSSQDVDYSGQSLTKF-PLM----R-
-----NKLDCENNASE--------LEESFHKRKEKSS-----------------------
------------------------------------------------------------
----------KNIESRKVKGKCPEV-R------MGEKQEGHEFKSQSQKT----------
--------------------------MKPKRTDWQLDIKHMLKSSDAN------------
--------R-LSNAKERSHVSEVK-------------------SWGD-SALVSDM----Y
RKSKGTQDLFLKPLSCKGN----------FEAPART---------------LG---TASD
APPGGPTTRAFADEELRD----RL-SDSEFRILE-------------EEILAWEKVHLEN
ESVSENL-LNKCEGIISD---------ATD----------QQGRSLD----------M-E
Q----A-TEVD--SE-------------GTSQLEQ---KNLDSSG-NTQP----------
---SNP-DPSKMC------------PQAQSTPAEPT-------MLIQPLSEEE----SK-
------------------------QAH------PPSL--------HLKKMSEDLEIN---
-------TKSDKECAPG----------HPEVPSVKAHGRESLTGDTTGKNREPKRSSPEL
--QHTAAGGLESICPVEEPLPGDCR-R-------SHFKVE---EGSRKQQWMELEVSELS
PADKKEEPAR-SVPDSCIKD-AQDSEK--EAWSPQEPVVTPEFEKSPPAG----------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------A---------D-LL------LLKDGHLLTK-
---------------------MDRVE-GRLTKREAKEKHK---TKSQVYE----------
-------------------------------------------------------M-EEA
SHGSE----------------------PRAP---AS--GWG--SDSPLKLWNT----THS
DERLIEL---KNSH-------------------CELLPRKPGKMGTM-------------
-----------REQTKIK---KIKTWSQHKEVA-WD-KL--CALRFPLKQDEKQEN-AEF
TF-QQKKPQ----LQREKEQ------------------CGGSVEWTQ-H-SEIRTVIAEL
KALEKDLR-QFHN-----------------------------------------------
---------------LKESWET---TYYK------YLHMVVKLQFIEQELIGIKTEQKKY
GHLL-EN----------Q-KNLEEEVLHLK--------SWMRESEIQAR-----------
----DQNN-----------------------------------IENLRDTN--D----TA
MISQMDLRIKNMESQLATRGAQR--Q----------------------------------
---------------------LLEEGCSDISTA-M----------QKRVVWPSP------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------MEGLPAAAVGG-----V-------------------------
--------------------------------------------------------LDPP
RPSP--------------FSQL-----------------------------VYTSNDSYA
IHHGDLKK-----IHK---------------AAWQGQD----------------------
RK---LQKMMKKKKTMD--LN-IRDAK------------------KRTAL----------
----------HLAC--AYGHEKVVILLVDRKCQIDV--CDGEKRTPLMK-----------
-ALQCRREACANILI-DSGADPTIIDVY----GN--TALHYAV-YIESVSMVAKLLSRGA
DTEVENKA-G---LTPLL------LSITRRNVQIVE-FLLTKNAN--------ANAV---
-NKCTC-------I----------------------------------------------
------------------------------------------------------------
---LQQLLEYKQKTSK-Y-LQNS-----NPEGTA------------------------EE
TPDQAAPLAEGTPDADARL--AEGT-PD--------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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-----------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TAL----------
----------HLAC--ATGQPEMVRLLVSRKCELNL--CDREDRTPLIK-----------
-AVQLRQEACATILL-QNGADPNITDFF----GR--TALHYAV-YNEDTSMIEKLLSYGA
NIEECSKC-E---FQPLL------LAVSRRKVKMVE-FLLKKKAN--------VNAI---
-DYLGR-------SA-LIHAVT--LGEK--DIVILL------------------------
---L-QHN-IDV--------FSRD------AFR-KIAGD---YA-SE---AEN---RV--
--IFELIYEYERKK-HEELSINS-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------D--------------
----------PA--AT--E-------------------------QDSMSKI---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------KKRKLIV
MKKKS-------------------------------------------------------
-------------MVIQRF-----------------------------------------
-LV---------------------------------------------------------
------------------------------------------------------------
-------------------TFCK-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------MKRLSAACVKGE------------------------------
--------------------------------------------------------TGPE
RPSP-------------------------------------------FSQLVYTKNDSYV
IHHGDLRK-----IHK---------------AAFQGQA----------------------
WK---LERM-MKKTTMDLN---IKDAK------------------KRTAL----------
----------HWAC--FNGHAEVVTLLVDRKCQLDV--LDGENRTPLMK-----------
-ALQCQREACANILI-DSGADPNIVDVY----GN--TAVHYAV-YSENLSVVVKLLSCGA
DIEVKNKA-G---HTPLL------LAIRKRSEQIVE-FLLTKNAN--------ANAV---
-DKFKC------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------I--H-------------------------QQLLEYKQ--------
-----------K------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--ISKNSQ-------------------------------------------NS-------
------------------------------------------------------------
-------------------------------------------------NP---EGTSEG
TPEEA-------------------------------------------------------
-------------TPLAER-------------------------------------T-PG
KAE---------------------------------------------------------
------------------------------------------------------------
-------------------GSV--EGTPDE------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------MNKLFSFWKRKN------------------------------
--------------------------------------------------------ETRS
-----------------------------------------------RTSSDPSIGQGYN
LREKDLKK-----LHR---------------AASVGDL----------------------
KK---LKEYLQLKK-YD--VN-MQDKK------------------YRTPL----------
----------HLAC--ANGHRDVVLFLIEQQCKINI--RDSENKSPLIK-----------
-AVQCQNEDCATILL-NCGADPNLRDIR----YN--TALHYAV-CGQSFSLVEQLLDYEA
DLEAKNKD-G---YTPLL------VAVINNNPKMVK-FLLEKGAD--------VNAS---
-DNYQR-------TA-LILAVS--DEPT--RLVKL-------------------------
--LL-QQG-VEL--------SCQD------ICG-FTAEE---YA-YF---NGF---TI--
--YPQFTASHGKKKHV--K-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

-----------------MKNLVHG----IK------------------------------
---------------------------------------------------------EKT
PMGF--------------CDVPGKNLLDFLR--------------DM-----KSIC-ANE
ARYKPRKK-----IHQ---------------AASEGDI----------------------
KK---LQRMINLG-KHS--VH-DRDFK------------------ERTAL----------
----------HFAC--IYGREEVVNVLLRNNCDIDA--VDRNSITPLMK-----------
-AVQNWSYGCMCTLL-KHGANPNHMDKN----GN--TSLHYPV-SEDNQKLVEYLLKYNA
DMEQKNND-G---FTPLL------LALKENKIEMAK-FLVKKGAN--------IHVF---
-DKMKR-------NT-LLYAIR--WDST--DLVSL-------------------------
--FL-DEG-IDF--------FFKD------VFG-WTVLR---YA-IE---GMS---K---
-GSRNILMDYEVKLHVKNKDGSL-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------MKRIF---SKKG------------------------------
--------------------------------------------------------ESPL
GSFA----------------RRRRSNSGGGG----------------EPGDGAYSQPGYH
VRDRDLGK-----IHK---------------AASAGNV----------------------
AK---VQQILLLRK-NG--LN-DRDKM------------------NRTAL----------
----------HLAC--ASGHPEVVTLLVDRKCQLNV--CDNENRTALMK-----------
-AVQCQEEECATILL-EHGADPNLADVH----GN--TALHYAV-YNEDMSVATKLLLHDA
NIEARNKD-D---LTPLL------LAVSGKKQQMVE-FLIKKKAN--------ANGV---
-DKLES-------SH-YLISEC--KEER--IPKNSSQNSVSADESSED------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------SLSRLSG--KPGI--------------D----D--SWPTSDD---------
--------EDVNFDIKN-------------------VPKPSLAKLMTASQQSKK---NLE
ATYDIVRT------------------GNRTSFEDRDSDSQ--------------------
---------------------D-------------------EVVI---------------
------------------------------------------------------------
-----------------------------ESLPT--------------------------
----------------------------------TSIKVQGFSHPT--NPLPDPLP-KLS
HKS---------------------------------------------------------
----------------------------------------LANP----------------
-----------------------------------GLTKEGTTKPATGKKE---------
---NGLDTIE----SPPLE--------------QTDNDN-------------LTYVDEVP
KNN----RSDMMTALGLGQEEDIESPWDSESI-SENFPQKYVD---------------PL
AGAADQKEKNIGNE---Q------AEG----------------------------MFYIP
SCMSGSRNFKMAKLEDTRNV--------------GMPVAHMESPERYHHLTPT----IEM
-KD----K-----------------------------AGGMK------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------NV------------------
---------------------------------------------QTSK-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------AA
EHDLEVTSEEEQER-KG-------------SENNQSQVE--------EERKKHR------
---------------------------NNEMEVS---ANIYDSATDDEDD----------
ED-VDDNDGLIQ---------ERRSGKTD----DQQFPRKENKEY---------------
---------VSSGPALQMKE-V---KK--GKPTSKESVNSLVFEKASLL-----------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------TGGLLQVDDDSSLSE-
-------------------IDEDER---RLTKKTSNEKNK---AKNQIQSMN--------
------------------------------------------------------DV-DDL
TQSSETASEDCELL--HSNYKNFMLLIEQLG---ME--CKD--SVTLLKIQDA----ALS
CERLLEL---KKNH-------------------CELLTVKIKKMEDK-------------
--VNVLQ----KELSETK---EIKSQLEHQKVE-WEREL--CSLRFSLNQEEEKRRNADM
LY-EKIREQ----LRGKEEQ------------------YRKEVEVKQQLELTLQTLEMEL
RTVKSNLN-QVVQERNDTQRQLSREQNARVLQDGIL-----TNHLSK--QKEIEMTQ---
-KKMNSENFH-----SHEEEKD---LLHK------NSVLQEEIAMLRLEIDTIKNQNQEK
EKKCFEDIETAKEKNEDLQKTIKQNEETLT--------QTISQYNGRLNVL-T------A
ENAMLNSK-----------------------------------LENEKQSK---------
--DRLETEVESYRARLAAAIHDR--DQSETSKRDLE----LAFQRARDEWSRLQDRMNFD
VSNLKDNNEILS--------------------------Q-QLSKTESKLNS--LEIELHH
AR-NALREKTLG-LER--VQTDL--SQTQCQMKE-----MEQKYQN-EQVKV------NK
YIGKQESVEERLSQLQSENMLLRQQLDDAHNKA---DSKEKTVINIQE----QFHAIVQK
LQAES-EKQSLLLEERNKELISEC-NHLKERQYQYENEKAER EV--VVRQLQQELADT--
--LKKQ------SMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQ-LQEAQDQHTEAVR
C-----------------------------------VEKMQDHKQKLEKDNAKLKVKIKK
QMDKIEELQ----KNLLNA-----------------------------------------
------------------------------NLSEDEKE-QLKKL---TELKQSLECN-LD
QEMKKNVELEREITRFKNL-----LKMTR--------------KKLNE------YENG--
--EF-SFHGDLKTSPFEMDIQINKLKHKIGDLTAELETAGSKCLHLDTK-----------
-NQVL--QQELLSMKTIQKKCEKLQKNKEKLEQEVVNLRSH---LER-NMVECGQVKQY-
KQEIEERARQEI-VEKLKEVNL---FLQAQAA-SQENLEQ-LREN-NFASM KSQMELRIK
DLESEL-SKMKTSQE------DFNKTELEKYK----QLYLEELKVRKSLS-NKLNKTNER
LAEVNTKLLVEKQQ---TRSLFT------TLTTRPVLESPCVGNLNNSLDVNRKLIPREN
LVI-STSNPRTSNNS-MEKYLTKMQQELEKNITRELEEA-AAE-----LES-----G---
--------------------S-AASPLGST---------ADS----ILNQDLVWKASREY
VQVLKKN--YMI------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

MVA-----EVDSMPAASSVKKPFVLRSKMGKWC---------------------------
----------RHCFPCCRGSGKSNVGTSGDQDDSTMKTLRSKMGKWCCHCFPCCRGSGKS
NVGTSGDHDDSAMKTLRSKMGKW-CCHCFPCCRGSGKSNVGAWGDYDD---SAFVEPRYH
VRREDLDK-----LHR---------------AAWWGKV----------------------
AR---KDLIVMLRD-TD--VN-KQDKQK------------------RTAL----------
----------HLAS--ANGNSGVVKLLLDRRCQLNV--LDNKKRTALTK-----------
-AVQCQEDECALMLL-EHGTDPNIPDEY----GN--TTLHYAI-YNEDKLMAKALLLYGA
DIESKNKH-G---LTPLL------LGVHEQKQQVVK-FLIKKKAN--------LNAL---
-DRYGR-------TA-LILAVC--CGS-A-SIVSL-------------------------
--LL-EQN-IDV--------SSQD------LSG-QTARE---YA-VS---SHH---HV--
--ICQLLSDYKEKQMLKISSEN--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------SNPEQ-----------
---------DLKLTSEE------------------ESQ------------RFK-------
--------------------------------GSENS-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------QPE--------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------KMSQEPEINK-----------
---DGDREVE--------------------------------------------------
---------EEMKKHE--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----SNN------------------------------VGLL------------------
------------------------------------------------------------
-----------------------------------------E-------NL---------
--------------------------------------------------SNG-------
------------------------------------VTA---------------------
---G---------NG---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------D-DGLI---------------------------P----
----Q-------------------------------------------------RKSRTP
----------------------------------------ENQ-----------------
--QFPDNE------------------------------------------------SE--
------------------E-----------------------------------------
----------------------------------------------------YH------
-RICELVSDYK-------------------------------------------------
------------------------------------------------------------
-----------------------------E------------------------------
-------KQMPKYSS---------------------------------------------
------------------------------------------------------------
-------------------------------ENSNPEQD---LKLTSEEESQRL------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------KGSEN-GQPEKRSQE------------------------
---------------------------------------------------------PEI
------------NKDGDRELENFMAIEE-M-----K--KHG--STHVG------------
-------------F-------------------PENLTNGATAGNGD-------------
--DGLIP----PRKSRTP---ESQ-----QFPD-TENEE--Y-HS---------------
------------------------------------------------------------
------------DEQNDTQKQFCEEQNTGILHDEIL-----IH---E--EKQIEVVE---
-K-MNSELSLS-----CKKEKD---FLHE------NSTLREEIAMLRLELDTMKHQSQLR
KKKYLEDIESVKKKNDNLLKALQLNELT MD--------DDTAVLVIDNGSGMCKAGFAGD
DAPRAVFP-----------------------------------SIVGRPRQQGMMGGMHQ
KESYVGKEAQSKRGI-------------LTLKYPMEHGIITNWDDMEKIWHHT-------
----------------FYNELRVAPEEHPILLT-----EAPLNPKANREKM---------
-------------------------TQIMFETFN-----TPAMYVA-IQAML------SL
YTSGR---------------------------------TTGIVMDSGD----GVTHTVPI
YDGNALPHATLRLDLAGRELTDYLMKILTERGYRFTT-MAEREI---VRDIKEKLCYVAL
DFEQEMAMAASSSSLEKSYELPDGQVITIGNEWFRCPEALFQPCF----------LGMES
CGIHETTFNSIMKSDVDI-RKDLYTNTVL-SGGTT---MYPGMAHRMQKEIAA-------
-------LA----PSMLKI--------------RIIAPPKRKYSV---WVGGSILASLST
FQQMWISKQEYDE-----------------------SG-------------PS-------
------------------------------------------------------------
-------------------------------------IVHRKCF----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------MKKIFGFRS-KG------------------------------
--------------------------------------------------------PSPL
GPSA----------------RPRNNCVGFGR----------------ESA-SGAHMPRYH
IHDKDMGK-----IHK---------------AASVGDV----------------------
AK---VQHILILGK-SG--VN-DRDKK------------------DRTAI----------
----------HLAC--AYGHPEVVTLLVERKCEVDA--RDGESSTALIK-----------
-AVQCQEEECATILL-EHGANPDMMDSR----GN--TALHYAV-LSENTSIVAKLLAHNA
NMEAKNKD-D---LTPLL------LAVKENKQHIVE-FLVKKKTS--------CHAV---
-DQLGS-------N--RQIFEY--DGKR---QK-NSENSNPVDNGSED------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------ESLSRSSR--IPDP--------------A----D--SWPSSDE---------
--------DDYSFDTKN-------------------VPKINLTELWAAAQQSKKN----Q
TKCGIENL------------------ENSSLFDNSNSNSE--------------------
---------------------N-------------------EDAV---------------
------------------------------------------------------------
-----------------------------EIGPG--------------------------
----------------------------------TSARVLAS-SPS--CTSPDP------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------VI----------------VESA
SQENGADVVE----RASQE--------------QPNHSN-------------LTYASGWH
KSN----KSEMMTALGLGEDEDEESPWDSESI-SDSVSLRGVD---------------RF
CGTADPTGEARVHG---Q------VED----------------------------VTYIP
SCMSGSRNFKMAKLEESRNV--------------GIPVAHKGMEKKLP----S----IKK
-PDPVVNK-----------------------------TAGMK------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------AVQT----------------
--------------------------------------------F---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------KS
VILT---------------------------VNFSSKA---------EEKRKYK------
---------------------------NNEAKLS---GSLYNGAADRV------------
------ENGVNQ-----------QSGKTD----DQQFPMKGSKEH-----------D---
-----------RGPPLLMKE-MKKTEN--EKCVSRESVTMPVTEKPGSP-----------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------PGDPLHLQDGSSLSD-
-------------------TDQSET---RPTKKTSNKNNK---VTNQVASVD--------
------------------------------------------------------NL-DDL
NESSETASEDCELQ--CPDYESVLCEIEHLR---ME--CRD--IVSLLKIRDA----VYS
YKRLIEF---KRSH-------------------CELLTGKLKRMENK-------------
--FKELQ----KEVSETK---EVRSLLEHEKAE-WEQEL--SSLRFALKQEEEKRRSADL
LS-EKTMEQ----LRRKDEQ------------------YQSEVEVKQQLEVSLRTLDMEL
KTVRNHLN-QVLEERNEIQRQLSQEQNARMLQDGIL-----ANHLCK--QKEIEMAQ---
-KRMTSEVSV-----SHEKEKD---LLHK------NQRLQDEIAMLRLEMDTVKRHNQEK
EKKYLEDIKTANEKSDKLQRTIKLNEETFT--------KTIFQYNGQLNNL-T------T
ENTMLSSK-----------------------------------LENEKQNK---------
--ERLETDVESFRSRLASAMHDH--AEIQASKRDLE----IAFQRARDEWLRLQDKMNFD
LSNLRDNNEILS--------------------------Q-QLSKTEKKLNS--LEIEFHH
AK-DALREKTLA-LKH--VQRDL--NQTQCQMKE-----VEHLYQD-EQGKV------NK
YMGKQESIEERLSQLQSENMLLRQQLDDASNKA---DSKDKTIVNIQD----QFHDMLGR
LQAEG-QKHRLMLEERNKELVSEC-SHFKERLCQYENEKAER EV--VVRQLQQELADT--
--LKKQ------SMSEASLEVSSRYRSNLEDEARDLKKKLGQLRSQ-LQEAQDQHREAVQ
H-----------------------------------TEKMQDHLQKLELENSNFKITIKN
QSEKIEQLQ----ENLSSV-----------------------------------------
------------------------------NLSEDDKE-KLKKL---AEVKESLECT-LE
QEQKRNDALEEELREFKEL-----LKKTK--------------KELSE------HENR--
--EL-NLHQDIKNSQFEMDIPVNMLIKKIDDLTSKLETTSSKCLHLGRK-----------
-NQVL--QQELLLMKTIQKKCVKLEKNKRKLEQEVESLRSH---MEK-NMVEHSQVQQY-
RREVEEQARQDL-VEKLKQVNL---FLQAQAA-SQENLEQ-LRES-SNASV RSQMELRIK
DLESQL-SRMKS-QE------DFDKIELEKYK----QLYQEELRVRKSLS-SKLNKTNER
LEEASTKLLLEEQQ---NRSLLS------SLSTRPIVECPCIGGLHNSLVFNRTLIPREN
IVI-PSSSLQPSNKR-MEIYLTKMHQELEKSINRELKEA-AAE-----LES-----E---
--------------------FCRVSPLGSA---------TKP------GQDLLSEASQEY
IDILKKK--YTIC-----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TPL----------
----------HLAC--AKGHVGVVRFLLTKNCDYNV--CDEDKRTPLIK-----------
-AVQYQFKECVQVLLL-KGAD--PNLIDHD--GN--TALHYAA-CG-KVSIASNLLFHGA
NIEARNKH-D---LTPLL------IAINEGNEDMVI-FLIRSKAD--------IHAV---
-DSQKX-------XX-XXXXXX--XXXX----XXXXXXXX--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------XXX------------------XX--XXXXXXXXX-------
---------XXXXXXXX-----XXXXXX-----------XXXXXXXXXXXXXX---XXXX
X-----------------------------------------------------------
---------------------X-----XXX--------XX------------------XX
------------------------------------------------------------
--------------------------------------X--XXXXXXXXXXXXXXXXXXX
XXXXXXXXXX------------XXXXX---XXXX-XXXXXXXXXXX--XXXXXX-X-XXX
XXXX--------------------------------------------------------
------------------------------------------------------------
--------------------------------XXXXXXXXXXXXXXXXXXX---------
---XXXXXXX----XXXXXXX--------------XXXXXX-------------XXXXXX
XXX----XXXVMSTLGSQ------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------G---------------
---------------HQRKICWISEXXXXXXX------XXXXXX----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------X------------
------XXXXX-------------------------------------------------
------XXXXXXXXXX------XXXXXXXXX-X---------------------------
--X---XXXXX---------------------------------------XXX--XXX-X
-----------------X----------XXXXXXXXXXX-XSKMKTLHLKX-----X---
XXX-XXXXX--------------------------------XXXX---------------
-----------------------------XXX--XX-XX-X--XX-XX------------
-----------------XXXXXXXXX-----XXXXXXXXXXXXXVREEKNKV---KSSTR
KGPE-----------NT-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------HQLAADFDDDGL-IKKG----------
--KSE-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------ETGKRFPVEENEDS---------------
-------DG--SSLDLPMLE-VKKYESQ--NWTPTSSAVTPVV-----------EK----
----------------------ANVLCGVLP-----------------------------
-----------------------------------EV--NTPDS----------------
------------------------------------------------------------
---------------SFSETDQEE---GRPAKKTSDMKTK---VSKNMGCVQ--------
------------------------------------------------------DD-ECW
SLTSETASEDCVLP--NSV-----TLLEQLA---MS--CN--DSLNLLKIQDA----ILS
YERVIEL---KKNH-------------------CALLTRKMKQMETK-------------
--CCALQ----MELRETK---EIKVELENEKME-WEQEL--SNLRFALAQEEEKRRNADI
LF-EVTKVQ----LKQKEEE------------------YNNEVKVKQQLEHTLSTLDLEL
KTARSNLN-KIVEERDDTQKQLSQEQNARILQDGIL-----SNHLCK--QKAIE------
--MAYK---KK-NSGNPSKEKQ---DSHP------NCPFRVLAEILQREVDALKNQIQAK
E-KYANDIEIMKAKNDVLQQTLNRREESGR--------RATTQYSEQLKEL-TA------
ENAMLRSE-----------------------------------LENEKLNK---------
--QRLETDIDSLQSRLAAAVQDH--EQSQKSTAELE----ESLQTTRNVCRHIWKKFKAD
KSHLKENNEALC--------------------------Q-KLSEMETKFSS--LENEFCC
TK-AALQEEIT------NLQRDI--KQSQSQLKE-----MEHQFQN-AQDKV------CE
S-RRQKLISEKVTRLQAENVSLQQKVHDAENKA---DSEEKEVMQLQD----RFHYVVNT
YQTNE--RQ--ELIEQIKELSNRC-DHLSERFCQGGKEKAERKX--XXXXXXXXXXXX--
--XKKH------PRPEGSIAVAVHYHPASEDEVQV-QKKLSQFRCQ-YEELQCQHAEVLQ
NAER-----------------------------------TQDNMQXXXXXXXXXXXXXXX
XXXXXXXXX----XXXXXXXXXXXX-----------------------------------
------------------------------XXX---XX-XXXXXXXXXXXXXXXXXXXXX
XXXXXXXXLEKSLK--------------------------ETKKKLNEXXXXX-------
---X-XXXXXXXXXXXXXXXXXXXXXXXINNLTEQLETSYSKCQHLEIQ-----------
-KQAL--QQELVAVKDVQRKCGKLEKRKDKLEQKVGHLRSQ---LEK-SAIDYAQVEQY-
KRDVEEKATQEL-VEKLKQVNL---FLQTQAV-SQENLEY-LREE-HNASMRSQMEMRMN
ELESEL-SKMKTSQNDS------QKTETEKYK----ELYFQELQLKSVLS-SKLEKANER
LSDISGKLAMEKQQNQQNQSFLN------SLMTRPALETPFVGTAQISSVFARNLP-REY
IGVSPTSTLAPT-DN-IDTYLAKMQEELQNNITRELEEA-HGE-----LES-----D---
--------------------MFRISPMGSR---------NI------FKNGPILKISQEY
GHILKKNSVL--------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

MVA-----EVDSMPAASSVKKPFGLRSKMGKWC---------------------------
----------CHCFPCCRGSGKSNVGTSGDQDDSTMKTLRSKMGKWCRHCFPCCRGSGKS
NVGTSGDHDDSAMKTLRSKMGKW-CCHCFPCCRGSGKSNVGAWGDYDD---SAFVEPRYH
VRREDLDK-----LHR---------------AAWWGKV----------------------
PR---KDLIVMLRD-TD--VN-KKDKQK------------------RTAL----------
----------HLAS--ANGNSEVVKLLLDRRCQLNV--LDNKKRTALTK-----------
-AVQCQEDECALMLL-EHGTDPNIPDEY----GN--TTLHYAI-YNEDKLMAKALLLYGA
DIESKNKH-G---FTPLL------LGVHEQKQQVVK-FLIKKKAN--------LNAL---
-DRYGR-------TA-LILAVC--CGS-A-SIVSL-------------------------
--LL-EQN-IDV--------SSRD------LSG-QTTRD---YA-VS---GHH---TV--
--ICQLLSDYKEKQMLKISSEN--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------SNPEQ-----------
---------DLKLTSEE------------------ESQ------------RFK-------
--------------------------------GSENS-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------QPE--------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------KMSQEPEINK-----------
---DGDREVE--------------------------------------------------
---------EEMKKHE--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----SNN------------------------------VGLL------------------
------------------------------------------------------------
-----------------------------------------E-------NL---------
--------------------------------------------------TNG-------
------------------------------------VTA---------------------
---G---------NG---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------D-DGLI---------------------------P----
----Q-------------------------------------------------RNSRTP
----------------------------------------ENQ-----------------
--QFPDNE------------------------------------------------SE--
------------------E-----------------------------------------
----------------------------------------------------YH------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TAL----------
----------HLAC--TSGQSPVVALLTQWWCDLNA--RDKEGKTALIK-----------
-AVQCQKEACVTILL-KRGADPNLADDH----QN--TALYYAV-LAGNTSIAAELLRYDA
NIEAINKY-N---LTPFL------LAQ-EEKEEMVK-FLIENGAN--------VHAV---
-DKLQS-------LS-QL------------------------------------------
--IV-DYR-DGK--------IPAI-------------------P-PQ---NSD---LG--
------------------------------------------------------------
-------------------------------------------GT------S--------
--------L---------------KITL----------A---------------------
------------------------------------------ERTGS--EVIK-------
-IAPRLEDVSVSRYFT--Q--------------TYID---D---SRPPSDG-----NL--
-----------DLAAK--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------HRTAL----------
----------HLAC--AIGREDMVKLLVDRHCQLNL--CDGEDRTALVK-----------
-AIQCQEEACVTLLLE-HGAD--PKVKDNK--GN--TALHYAA-HEGIVSIAEKLLLQNA
NIEAKNTD-G---LTPVL------VALNENKEQMVK-FLVGKGAR--------LLSG---
-DTVKS-------SD-QLISEH--EEEM----KPENSSQN--------------------
---------HDL--------VAKK------SE----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------EVSLSSRTR--KADT------------------DD--SRPSKHEDL-------
---------SSGTKT-------VPKLN--------------LRKQMAA------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------FLRPKSK-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------IE---------
---AKCGLVS----QEDRPLF--------------ADNNFA-------------REDKTE
T------LCK---PSVNVSD---YSPLAF--V-SPETPQTSSA-----------------
-------------------------------------------------------M----
------------------------------------------------------------
-------------------------------------------LG-----VTKVRKHS--
RA---SPGT------PKQELCLYIVQSENRED------VNKHDLQAQMNY----------
----------------------------------------VEE-----------------
------------------------------------------------------------
---------------IK----KLN------------------------------------
-------RSKMW------SYNNFAR--------------EDKT---ET------------
------LCKPS--V----------------------------------------------
----NVSDYSPLA----------FVSPETPQ-----------------------------
--TSSAMLGVTKKHSS------SEAKVE-QML-----------YIIKCGRNYFKCKLI-K
------------------------------------GN--IVVLLLEHLKE-----D---
KTE-TL------------------------------------------------------
----------------------------------CK-PS-V--NV-SDYSPLAFVSPETP
QTSSA---MLGVTKVRNGS-----PQ-----EYKRKQCNNNREHTGKERKQH---TSNKM
EGAE-----------NIYDAAAAAAAAPALG-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------TA--LAVAA--------AA---AAAAPAAGL-IQQR----------
--KTGK------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------TDNHLFPTTQNEDS---------------
-------DS--NDPGLSIME-IKKDKNV--KWVSKASVITPGF-----------EE----
----------------------ADSLTGSLL-----------------------------
-----------------------------------RV--SNDN----S------------
------------------------------------------------------------
----------------LSKMDQDE---RRPAKKTSKEKNK---VKKQVNSAE--------
-------------------------------------------------HLDDEHL-DDL
TQSSETASEDCKLQ--SSDYKSSLLLI-ELG---MD--CKGVDSVSVLTIQNA----ILK
YKRSIEL---KRKD-------------------CEQLTRKILQVEYK-------------
--VNGLE----QLLSETK---EMKSQLEHQKVE-WEREL--YSLRLTLKQEKEKRRSAEI
LY-INIKEQ----LRSKEAC------------------NTLGILFSRKLPLNIILLFYNL
ETVKMKCL-IYLKPNNILQFQVSSSKTGRALQDGIL-----NNHLCK--RNESE------
--MSHTKMNSE-VSPPHEKEKG---LLHE------NRMLQDELAMLRLEIDTIRNQKQ--
EKRYCEDTETEKEKNDSLQNAIKLNEVTLT--------NTVFQSSGQLNVV-TT------
ENTMLNSK-----------------------------------LQDEKLNR---------
--ERLEAKLQSYRARVATAIQDR--DQSQASKRDLE----LAFQRAKDEWCHLQDKMNFE
MSNLKDNNEVLS--------------------------Q-QLSEVESKLNA--LEIELQY
TR-DALREKTLA-LEH--LQRNP--KQTQGQKKE-----IEQKSQN-EQGKV------NE
YMGKHESLEEKLSQLQSENMLLREQLDDAYSRV---ECKEKTIIYLKD----QVQVIVRM
VRVAG-EKRALQLRERNKELINKC-KQIMERAFRYEDEKEER EV--VMRELQQELADA--
--LKKQ------CMSQASPE-LSHYRINLEDEVQDLK-TLDQIESH-RQEAKELQTKVVR
CVQK-----------------------------------FRDDIKKLEVENAELKVTVKE
QAGQIEQLQ----KDLLSSSSREKW-----------------------------------
------------------------------STE---KK-KLKSC---REMTSLETQM-LD
QEAKKNEELEKENTGLKNH----LINMLR--------------RILSK------YENGE-
---L-PFYGDLKTSQTEMEIQINMLRQKIGDLRAIFETASSKCIDLDAK-----------
-NQVL--LQELLSTKATERECEKLKQIKKNLEEKVVNLRSH---AEV-NVVQGIQVEKYY
KWEIDQRARLIV-EERLKEVNL---VLQRQAA-SQENLEQ-LRAS-HDASI SSQVALRIK
ELESELQSQIRNSQE--------LKIELEKYR----QLYLEESEMRMSLT-KKLSKTNER
LADISTKYLVERQQ---NRPFHS------TLTMGPVLEGPSVGNLTSSLLLDRNVTPREN
VMI-PTSRPQTSVSS-IETHLFKMQQMLEDSIIRELKEG-VDCA--ISLQS-----H---
--------------------LVISSPLGPT---------DES----NVNQDLVLQASREY
VEILNR--KYMI------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------MKKFFGFGAGKG------------------------------
--------------------------------------------------------RSSP
TFRT----------------EPMNGLRARAD----------------KNEEVNKSQRGYD
VRVKDLKK-----IHR---------------AAAVGDV----------------------
AK---MQRLLLLGK--D--VN-KRDKM------------------KRTPL----------
----------HLAC--TIGHADMVTLLVERKCQLNL--CDRECKTPLMK-----------
-AVQCQEEACVTILL-EHGANPHLTDNF----GN--TALHYAV-AGENTSIVEKLILFHA
NIEARNKF-E---LTPFL------LAVNENKHQMVE-LLIGKKAD--------VHVV---
-DKSKR-------TA-LMLAAT--SKSP--DV---------------------VRLL---
---L-QQG-VNT--------SSRD------ECG-WTAED---YA-VF---GGF---DV--
--NRQIIA----QHREE-----R-------------------------------------
IKN---------------------------------------------------------
---------------------------------------------------FS-------
-------Q-----------------------------------------------N-NNP
VTNKSFEEDSLSSISI--KPGD--------------D---NA--SWPTSDD---------
--------EDLSFNMKE-------------------GEE---------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------QPVIETK----------
----DDGITE----SVPQA--------------QTVNDC-------------LTSADRAD
KND----RHVMLSALGFAE-QNEESPWDSESN-SESLPEKYID---------------HL
SGNADQKGTSPLNE---Q------VED----------------------------VFYIP
SCMSGSRNFKMAKLEDTRNV--------------GLPVAHMDSPEKYSFLKPT----VEE
-KDSVPKK-----------------------------GGEME------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------EKQT----------------
--------------------------------------------SKSDSP----------
------------------------------------------------------------
------------------------------------------------------------
---------------GKCS----------YLKP------AVE------------------
------------------------------------------------------------
---------------------G-----KDF-------VPNEPG-EME----------E--
------KEASKSDSPEKYFHLKPAVE-------GKDFIPNQPGEM---------EEIQAC
QTDSPGKYSYLKPGVEV----NHSLPNKPGEMEEKE---------T---S----ESDFSA
ELDLEMTTEEEEESLSE-------------SENKHLQI---------EETKRHQ------
---------------------------NDETAVL---ESIYASAA---------------
-------AGLMH---------PIGSGKTD----NNLCPITENEE----------------
---------SDGDPALDTKE-LMKGEK--EKQTSKESVIIPRFEKAPSL-----------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------TSRPLQMNDDSTSSG-
-------------------MDQDEG---RPGKKTSSEEEE---VKKQIDSVD--------
------------------------------------------------------DL-DDL
TPSSETISEDFHMP--CSNYMICMSLIEQHG---MD--CKD--SVSLLKIQDT----VLS
YERLIEL---KKNH-------------------CGQLKRKNKKMENK-------------
--ANRLQ----KELSETK---EVISKLELQKVE-WEQEL--CSLRFTLKQEKERRRNAEM
LY-EKIQEQ----LIRKEEQ------------------YNKEVEMKQELELNLRTLDMEL
RTVKNDFN-QVVEEWNDTKKQLCREQDARILQDGIL-----NNHLCK--QKEIEMDN---
-KRS-----SG-ISNSHENEKY---LLHN------KYILEDQIAMLRLEIDTINNQSQEK
ERKYCEDIEILKEKHVSLQKTIKLNEERLT--------KTELQHSGQINAL-S------I
ENTMLKSK-----------------------------------LENEKQNK---------
--ERLDEKVESYRARLAAAIQDY--DQSQTSKRDLE----LAFQRAKGEWFRVQDKLNFD
VSKLKEDNELLS--------------------------Q-NLSEAESKFNT--LETELHR
TR-DALREKTLV-LER--VQRDL--SQTQCQKKE-----IEHSYQS-AQDKV------SK
YIGKQESLKERLSQLQSENMLLQQQLDDAHNKA---SSKEKVVINIQD----QFQDILKK
LEAES-QKQALIIEASKQELINER-NLLRERMYVYEKEKVEREV--AVRQLQEELADT--
--LKKQ------SMSEASLEVTSRCRMNLEDEVQDLKKKLAQIRNQ-LQDAQERHAEAVT
R-----------------------------------IETLKDHVQKLEVENAELKDTITK
QVEKIEQLQ----ENTLST-----------------------------------------
------------------------------CSSDDEKG-QIKKF---IELKQSLECS-LN
QEMKKNGELEKEIARFKKL-----LKVTR--------------KKLSE------YENE--
--DL-SFHGDLRTSHAETDIQINMLKHKVDDLTAKLETLSS-------K-----------
-NQVL--TLELSSMKEIQTKCEKLEKNKKKLEQQVVNLRSC---VEV-NMVEYSKIEQY-
KRELEERTRLNI-EEKLKEVDL---FLQTQVA-SQESLAQ-LREN-NNASLRSQMELRIK
ELEFEL-LKMKSSQE------DLTKTELDRYK----HLYLEEVTHRMSLT-NELNNCC--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------MRKLFSFGRRLG------------------------------
--------------------------------------------------------QELL
DS----------------------------------------------MD-QEYAGRGYH
IRDWELRK-----IHR---------------AATKGDA----------------------
AE---VEHCLTRRF-RD--LD-ARDRK------------------DRTVL----------
----------HLAC--AHGRVEVVTLLLSRRCQINI--CDRLNRTPLMK-----------
-AVHCQEEACAIILL-EHGANPNIKDIY----GN--TALHYAV-YNEGTSLAEKLLSHHA
KIEALNEE-G---NTPLL------FAINSRRQQIVE-FLLKNQAN--------VHAV---
-DNFRR-------TA-LMLAVQ--HNSS--NIVSL-------------------------
--LL-QQN-INI--------FSQD------LFG-QTAED---YA-VC---YNF---RS--
--IQQQIL---E------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------H--------------
------------------------------------------------------------
-------------K-----------------------------NK-------I-------
-----------------------------LK----------NHL----------------
------------------------------------------------------------
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-----------------------------

------------------MKKIFGFGSKKG------------------------------
--------------------------------------------------------VSPL
GSAS----------------V--------GQ----------------KNNRIDNFLMGYH
VRDRDLGK-----IHK---------------AACVGNV----------------------
AK---VQQILFLGK-NG--VD-DRDKM------------------NRTAL----------
----------HLAC--ANGHPEVVTLLIERKCHLNL--CDNENRTALMK-----------
-AVQCQEEKCVNILL-ENGADPNIRDLS----GN--TALHYAA-FGDNISIIEKLLLYNA
NTEAINKD-N---FTPLL------VAVNENKQQIVE-FLIEKAAN--------IHAV---
-DKLKS-------NY-EIICRH--KEEI--MLKNSLQNSNPVEDKNSEE-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------DSLTRLSD--KPGI--------------D----D--SWPTSDS---------
--------EDLDFGTKN-------------------VPKPSVAKLLHSSGQFMK---NMR
AKRGSVKA------------------EGGTLSEDNNPDSE--------------------
---------------------N-------------------EDVG---------------
------------------------------------------------------------
-----------------------------ETLSK--------------------------
----------------------------------PPTRDYGDSLPI--FPSAKSLLKP-S
L-----------------------------------------------------------
--------------------------------------KTLAVL----------------
-----------------------------------GLPKEGIAKSAVEAKE---------
---DGIGIIE----NVPPE--------------QTVNDS-------------LT-SGGVH
KNY----RSDMMSALGLGEEEDVESPSDPESM-SES-PNKYVP---------------HL
SGAVDQKGQSILSG---Q------VED----------------------------VFYIP
SCMSGSRNFKMAKLEDTRNV--------------GIPVTHMDPPDKYPHLKPT----VEV
-EDSFSDK-----------------------------TVGMK------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------DIQT----------------
--------------------------------------------SRSDFSDWESTSL---
------------------------------------------------------------
---------------------------------------------------TFG------
NETCQTSKNLK--VDDKCP----------FVSQ------PMI------------------
------------------------------------------------------------
---------------------K-----NQS-------A----------------------
---------STDSGPITLVDKEKI----------------NMGTV---------LLLGNC
T--------------------LHDL------SESQL---------P---E----NRESKE
DLDLELTSVEERERLDG-------------SENNHPQYQ---VPLKVEEKKKHR------
---------------------------SSDMEVS---ENIHDAAA---------------
-------AGLIQ---------QRKNGKTD----NHQFPVTENKDS---------------
---------DSSEPGLHMKK-LKKGED--EEGTSEESVITPVLKKADSL-----------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------TGGLLQMNEGSSLSE-
-------------------KDQHES---RPAKKISKKKNK---VKKQVTSMD--------
------------------------------------------------------DL-VDL
IQSSETASEDCELP--Y--SKNFMLLIEKLG---TD--CKD--TVGFLKIQDI----VFS
YERLMKL---NKSH-------------------CKLLTGKIKKMEKT-------------
--VSALQ----NELREAK---DMKSRLEHQKVE-WEHEF--CSLRFTLKQEEEKRRNADM
LY-EKIRER----LRRKEDQ------------------YNKEVETKQQFELALRTLNMEL
KAAKNHLN-QLS------------------------------------------------
--------------DSHEKQQD---LLHK------NHMLQDEIAMLRLEIDTIKNQNQGK
ETKYCEDIEIVKEENDNLQKTIKQNEETLS--------KTIFQYSGQLNVL-T------A
EIAMLNSK-----------------------------------LENEKQNK---------
--ESLEAEVESYRARLATAVHDH--DQSQTSRRDLE----LAFQRARDEWFHLQDKMNFN
VSNLQDNNEVLS--------------------------Q-QLSQVESKLNA--LEIELHH
TK-DALREKTLV-LEC--VQRDL--SQTQCQKTE-----IEHMYQN-EQSKV------NK
YIAKQESLEERLSQLQSENTLLRQQLDDAHNKA---DSKEKLVINIQD----QFQNIIKK
LEAKS-EEQGLMLGERNKELIDEC-KHLKERMYHYENEKAKI EV--VMRQLQQELADT--
--LKKQ------SMSEASLEVTSRYRLSLEDETRDLKKKLGQVRSQ-LQEAQDRHAEAVR
Y-----------------------------------AEKTL------EVTNTTQEETIKQ
QAAQIQDLQ----SNLLRT-----------------------------------------
------------------------------SL----------------------------
------------------------------------------------------------
----------------------------ADDLTTKLETTSSKCLHLDAK-----------
-NQVL--QQELLSMKALGKKCEKLESNSKKLQQEVVKLKSF---MEM-NMVERSQVEQY-
KREIEERARLEI-VEKLKEVNL---FLQAQAA-AQENLDQ-LREN-AHASM RSQMELRIK
DLESQV-STMKTSQE------DSTKTELETYR----QLYLEELKARKSLR-NKLNRTNER
LSEINTKLLVERQQ---HQTLLG------TLTLRSGLEPPYCGHFENNLVLNRNLTPRGN
LVI-PTSNPRPSYDY-RETSLWKMQWELEKSITRALEEA-ATE-----FES-----G---
--------------------SCR-TPLVST---------DDS----ILNQDLVWKASQEY
VKILNKN--YMI------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--MTS---------------RGGEKRGGSEGSPKPTVSAMRKTPSV--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------GSVRSQEDQL-
----------SLSYQGDRWSSDSSWL--SDSAGSDSE--------H-------------V
EGAL--------------------------------------------------DQP---
-----QHDVRLEDLCELHRA--------------ARSGD-------VP-----GVERVLA
PGD-----------------------------------PGEGGTR-AV------------
-----LLGTPAFWYWHPTNLTVSDKTCQKSKILNVDDQCPSVSPSMPENQSATKELGQMN
LTEQEKM----------N---------------------VSGNDSLH--DLC-QSQLPE-
----------------------NKESK---------------E------AEQDLELTSEE
E---QERLKGHENKQPQ----KMSQEPEMAKDSDRED------------------IPVYS
ILPHAQKSEEMWIEQDKLEWKNKLKL-----------VTNELKQRFGE------------
------IRETYKIP----------------------------------------------
----VCPEEEPLLDNSMRKTNVKDIPFNLTN-N-------------------------IP
GCVEEDASEVSVSVVFKTFPEQNEPSLKSIIH---------PYSHPYSGSLEHACQSSSK
LHLHENKLDYDSDNKPGIEHIFSMDEN-FSNDAGIKKAR-NPEEVTVEMKE-----G---
QEF-DLQMTKNMNQNIDSC-----------------------------------------
---------------------------STNNYKSLKPKL-E--NL-SSLPPDSDRTSEVY
LHEELQ---QDMQKPKTEVDRVEEMF-----LALKKENVQLQKEVEEEVEKH---RSNST
ELSG-----------NPAHGAAAG------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------NN-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------VKNQVH-----------
---------------------------------------------------PEADF-ADS
VGPSETASEDCELS--HSTYENFLLLIEQLG---ME--CKD--SVSLSRIQDT----FCF
YEHLLKL---KNND-------------------YEQLTVKIKQTENT-------------
--VSVLQ----KELPETK---KTELQLELQKIE-LEKQL--YSLRLALKQEKEEKGNAVM
LY-NKYSEQ----LRLKEEE------------------CGKEVETKQRLKWTLRRLVKEL
KTVRNSLD-LVVQERNDVQKQLSEEQNARILQDQIL-----TS---K--QKELE------
--IAQEKINSE-ISHRHKKEKD---LLHE------NCMLQEEIALLRLEIDTVNNQNQQK
EKKYFEDIEVVKEKNDNLQKIIKLNEEKLT--------ETILQYSGQLNDL-TA------
ENKILNSE-----------------------------------LENEKQNQ---------
--ERLEIEMESYRCRLAAALHDC--DQSQT-SRDPK----LDFQRTRQEWIHLQDKKKVD
MSDLQAKTELLS--------------------------E-KLSNAESKISS--LQIQLHN
TR-DAVERKSLI-LER--LQRDL--SQTHREKKE-----IEQMYQT-EQRKL------KK
YIAKQESVEERLSQLQSENTLLPQELDDAHKKA---NSQEKTISTIQD----QFHAFAKN
LQAES-EKKILSLQEKNKELMDEY-NHLQERMHQCEKEKAR RKV----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------DLIEAQETAPSRCLHLDAE-----------
-NEVLQLQQTLFSMKAIQKQCETLQKNKKQLKREVVNLKSY---MER-NMLECVEAEQH-
KLLIKEKAKKEI-AEKLNEAIL---TLQKQAAVSQEQLAQ-LRED-NTTSV KTQMELTIK
NLESEI-SRINTSSADF------NKTELERYK----ELYLEEVKVRESLS-NELKRTNEK
IAEVSAQLTVEKELTR---SPFA------ACSTRPILEPPCAGNLNDSEDLNRKHIPRKK
KSA---------PES-MESYLLKVSYLFSFGVHIKMCLL--LCGCTGF------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------MRKLFSFGRRLG------------------------------
--------------------------------------------------------QALL
SS----------------------------------------------RD-KEYAGPGYH
ILDWELRK-----IHR---------------AAIKGDA----------------------
AE---VERCLR-RF-RD--VD-ARDRK------------------DRTVL----------
----------HFAC--VHGHIEVVTLLLRRRCQIDI--YDRLNRTPLMK-----------
-AVHCQEEACAIILL-ERGANPNIKDIY----GN--TALHYAM-YNKGTSLAEKLLSHRA
NIEALNEE-G---NTPLL------FAINSRRQQMVE-FLLKNQAN--------IHAV---
-DNYRR-------TA-LMLAVQ--HNSS--SIVSL-------------------------
--LL-QQN-VNI--------FSQD------MFG-QTAED---YA-VC---CDL---RS--
--IQQQILEH--------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------K-----------------------------NK-------I-------
-----------------------------LK----------NHLR---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------N----------------------------------------------------
------------DNQETAA-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------VK-------------------------------------------PA-------
------------------------------------------------------------
-------------------------------------------------NL--K------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------K
------------------------------------------------------------
----------------------------RK-------EGAKA------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------EHNLKVASEEKQERLER--SGNKQPQ-----------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
-----------VSQSY--QKSYL--KQAQHQIKE-----MKQMHPS-EEAKE------SH
SIGKQNSLEERIRQQELENLLLEQQ-LKDAYKE---GNNEEIVINIQE----DCL-----
---DN-GKEDLLLEEKNKELMNEC-NYLKEKLFQYEKEAA E-EV--IVRQLQEELANH--
--L-KF------PMSDSPLEGTSHCHINLDE-TQASKKKLFQVGSQ-PEGKHEEFG----
------------------------------------------------------------
-------------K----------------------------------------------
-------------------------------------------F---FELISSLEYN-AD
QIRKKNHELEEETTGYKKC-----LEMTI--------------NMLNV------FGNE--
--DF-SCHGDLNTDQLKMDILFKKLKQKFDDLMAEKEAVSSKCVNLAKD-----------
-NQVL--QQEFLSMRKIQEKCEKLEEDKKMLEEEVLTLKTH---MEN-NMVELGKAQEY-
KSELDEKTMQII-EKLEEI------HLQEQAQ-YEKQLEQ-LNKD-NTASL-N RKELTLK
DVECKF-SEMKTAYEE-----V--TTELEDYM----EAFAVALKANNSMS-KNLMKSNKK
IAVISTKLLMEKER---MKYFLS------TLPIRPDPELPCIENLNSIG-LNRKDISKTP
VRI-PTSNPQTSNNC--ENSLTELLMCWALAP-----------------VY---------
FLL---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TAL----------
----------HLAC--TSGQSPVVTLLIEWRCDLNA--RDKEGKTALIK-----------
-AVQCQKEVCVTILL-EQGADPNLADDF----EN--TALHYAV-LAGNTSVAAELLRYNA
DIEAINKY-N---LTPFL------HAVRKNKEEMVK-FLIENGAN--------VHAV---
-DKLQS-------LY-QLIVDY--RARR--IPNTPPQNSDLGRTSLKLTLAER----TGA
E-----------------------------------------------------------
------------------------------------------------------------
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-----------------------------

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--MAF---------------WGGEKRGGTEGSLTPAVSAMRKTPSV--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------ES---QEDQ--
-------------------------RWWKNSA-VESE--------H-------------D
EGAL--------------------------------------------------DQP---
-----QHDVRLEYLCELHRA--------------ARSGD-------VP-----GVERVLA
PGD-----------------------------------TGVDKRD-RKKSIQQLIPEYKE
KQTPESLPQNNNPDWHPTNLTLSDKACQRSKILNVDDKCPSVSPSMPENQSATKELGQMN
LAEREKM----------NIG-VIL---------------LSENDTLR--DLC-QSQLPE-
----------------------NKESK---------------D-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------G-----N---
KEF-DLQMTKNMNQNSDSC-----------------------------------------
---------------------------STNNYKSLKPKL-E--NL-SSLPPDSDRTSEVY
LHEELQ---QDMQKFKNEVDTLEEGF-----LALKKENVQLQKAVEEEIEKH---RSNRT
EITG-----------TLTDGATV-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------KNQIH-----------
---------------------------------------------------PGADF-ADS
VEPSETASEDCELS--HSVYENFLLLMEQLR---ME--CKD--SVSLAGIQDT----FCL
CERLLKL---KNNR-------------------CDRLRVKIKQTENT-------------
--VSVLQ----NELSETK---KTKLQLEHQKIE-WEKEL--YDLRLALKQENEEKRNANI
LY-NKDNEQ----LRIKEEE------------------YKKVVETKQQLKGNLRRLVKEL
RTVRKNLD-LVMQERNDAQKQLSEEQNARILQDQIL-----TS---K--EKELE------
--MAQKKINSE-ISHRHQKEKD---ILHE------NCMLQEEIALLRLEIDTIKNQNKQK
ENQYLEDIEVVKEKNDNLQKIIKQNEETLT--------ETILLYSGQLNDL-TA------
ENKILNSE-----------------------------------LKNEKQNQ---------
--ERLEREMESYRCRLAAALC--DYDQSQT-ARDLK----LDFQRTRQEWIRLQDKRKVD
MSGLQAKNEILS--------------------------E-KLSNAKSKINS--LQIQLHN
TR-DALGRDSLI-LER--VQRDL--SQAQCQKKE-----IEQMYQI-EQHKL------KE
YITKQESAEERLSQLQSENMLLRQQLDDAHKKA---NSQEKTISTIRD----QFHSAAKN
LRAES-EKQVLSLQKKNKELMDEY-NHLKERMDQCEKEKAG RKV----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------DLTEAQETAPSRCLHLDAE-----------
-NEVLQLQQTLFSMKAIQKQCETLQKNKKQLKQEVVHLKSY---MEK-NMLKHAEAEQH-
KLLIEERARKEI-EEKLNEAVL---TLQKQAAVSQEQLAQ-LRED-NTTSIN TQMELTIK
DLESEI-SRIKTPQADF------IKTKLEIYK----ELYLQEVKVRESLS-SELNRTNEK
IAEVSAQLTVEKEQTR---SPFT------AYTTRPVLEPPCAGNFIDSEDLKRRHIPGIK
RSA---------LNS-VESYLLK--QKLQNDITTEVAGS-SQTGLHRTLQC-----S---
--------------------SFSSSSLHLLLCSVCQPFFLVLQVFINHASTKKPTIS---
----RQN--WNRCPS---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------M
KAIECQKEQCAIILLD-HDADPNLVDAKHN------TALHYAA-LIPNVSLAGHLLEHRA
HIDVQNQE-G---YTPLL------LAVIQNHQEMVE-FLLKKGAD--------VNAR---
-DNFKR-------TA-LILAAK--GEQT--GMIKLLLEHN--------------------
---------ADT--------YLED------DQG-WTAEN---HA-TF---SGF---HA--
--HSLLIAQYALQKNPKQCSSSIF---NSPDRAFV-------------------SGFTLG
GPA------TDKKGMDE-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----SSSESLSRASN--KPSP------------------SD--SWPPSDEEE-------
---------SD-FSTKK-----PAK--------------PNLSRLINAS-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------QQIKKD----DEKSSLVRT
ERITFLG----------PSMSSSEKEDVTESPPKPSPHVQCIPHPV--LPLPGSFSKPPL
MTST--------------------------------------------------------
------------------------------------------------------------
--------------------------------PLLNIKKEESVETEDEEEN---------
---SGN-SSD----DAPKEQP--------------HSFKSLTKSLNSSTGYLKTQNTSQN
CAL----GGDILPELGVEEEE---ESWKSESA-SESTPERSVP--H-------------L
PAARSNEPTNSISK------------------------------------EKSEDIFYEP
SFVSGSRNCNMNKLEDVRNL--------------GRPVDHMDNYENHPVSKSNTTKAVVS
KDSV--NQEEE---------------------------QMVKQNR-----TSDFMEEFGL
DN---ADDIEDASDWDSTDTSYKNSQNVPQ--------YSPEVKRAQKDSNG--DLEDAT
IS---SSSRHSEKSPVPKNSS---------------------------------------
--EEA------HEGLSGSIPQQDKVML---------------NICSLTE---KTAL-EKQ
T---NKARMSISHLKTK----SEGLETNEEM-C---SGD----------------LPLDS
KLNWEERYEKLWADKEKMKVKMSFKS-----------ITAELKKMFGE------------
------TFEENKIA----------------------------------------------
----PMSRVEPLQDISKESETVGEPPHNLRK-N-------------------------IT
EPEDQDKIGVFLTVTLPQFSGKGEKGLENSSS-----------YNLNSNSQENTTQSSFK
LCTSSNTLGSE----NDIGCICNANEEGLADDAENTKIS-SLKIAANKL-----------
--F-IKQTAGNKDRIFTSWESVSGKNLECVLKPSSTEEALSTGLTYPEVMRPISPEKAHT
LSAETYNAEKTDSRLNSHQSHNHRGRKAGNS---TVTEN-K--KW-KHSISFYDKISQAH
PDEELQ---QAMQGFKKEVGVLEIGF-----LTLEKQKMQLQKEVEEEKIKH---KYDEM
GTLE-----------KRHESDKSVQEKM--------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----AK-----I------------------------------------------------
------------------------------------------P-----------------
------------------------------------------------------------
-------------------------------RQHSQ------------------------
-------------INNTVSS-KERSPLILSHWKSHDG-----------------------
------------------------------------------------------------
---------------------------------HFAG--GE-------------------
------------------------------------------------------------
----------------GSKETPDQ---QKSAEKGIHKKSK---EPAQMAVDG--------
------------------------------------------------------DL-DDL
TQSSDTATEEFDFP--SLNTKNPMLLIEQLG---VH--CN--DSAGLLQVQNA----FLS
CERSVEF---EKGR-------------------YQLLLSKVELMKKE-------------
--KKELQ----EELSETR---EIKSKLEHEKVE-WESEL--SSLRFTLKQEEEKKLSMEI
KY-EKAREQ----LKRKEDQ------------------YCKELEMKQQLELTLRTLDLEL
RTVRNNLK-QVEEERNDTQRQLSQEQSARALQDDIL-----NNHIWR--QKEIEAAQ---
---KTATHSSE-IPDNHEKEKE---LQHI------NQKLQEEIAILKLEVDTARVQNQEK
ESRYVDENEALKEKNEDLQKELKLNA----------------------------------
ENAMLRSQ-----------------------------------MENEKQNK---------
--DRLETEMESYRSRLSTAIQEH--EKSQVAKSDAE----RKFQRERDEWLRLQDKLNHD
LSNLRDTNGVLS--------------------------Q-HLSQAESKANG--LENELHR
LR-DIIREKSLS-LES--AQRDL--QQTQCQAKE-----LERVCQN-EKAQM------TK
FTVKQESMTERLAQLQSENALLRQQLEDAQNKG---IVQDKVVNDVQV----LFRDIVDK
LHAES-DKQILLVEERNKELTCKC-SHLREQLYKSETQQADREA--TIRQLQQELADS--
--LKKQ------SMSEASLEVTTRYRNDLEDEKQQLQKELDKIRNK-MQESEELQMQYKR
CNHE-----------------------------------LEDHVQKLEIENTTLEATIKQ
QTTRIELLQ----KEPQDSSS---------------------------------------
--------------------------------SENEKE-NLKKL---NQIKRSLE-NRLE
HEIKKNQELQKNIDGQQQ------------------------------------------
------------------------------------------------------------
------------------KNYEISEKIKRQLEEEMVNLKRY---QEM-NMFERSQMEQY-
KREVDEQAKQEI-VKKLEEVNL---FLQTQAA-SQETLEK-LREN-NNASLINQMETRIK
DLEMEL-ARLKNSSQNNTFQKDPTQAELERYR----GLYNEESNIRKSLS-SKLDRANER
LAETNVKLLSERQK---RRSLIS------SLTSSPVLEPTHLGNLSYSFVFNRGLDLGGS
FLG-ATPSTPSSETT-VETYLTKMRQELDRKITKELAEA-NTE-----LQF-----A---
--------------------TLRVSPQGST---------DDSSRNPNCHRDPAARATQEY
LDILKKN--YMI------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TPL----------
----------HLAC--AHGFPNVVALLIEKKCKLNL--LDKKGQTPLIK-----------
-AVECQQEDCAAILL-ERGADTLHWDTY----HN--TALHYAA-CGHNIKIATKLLRHNV
VMKARNKV-E--------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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-----------------------------

MVA-----EAGSMPAASSVKKPFGLRSKMGKWCRHCFPWCRGSGKSNVGTSGDHDDSAMK
TLRSKMGKWCRHCFPWCRGSGKSNVGTSGDHDDSAMK-----------------------
--------------TLRSKMGKW-CCHCFPCCRGSGKSKVGPWGDYDD---SAFMEPRYH
VRREDLDK-----LHR---------------AAWWGKV----------------------
PR---KDLIVMLKD-TD--MN-KKDKQK------------------RTAL----------
----------HLAS--ANGNSEVVKLLLDRRCQLNI--LDNKKRTALTK-----------
-AVQCQEDECALMLL-EHGTDPNIPDEY----GN--TALHYAI-YNEDKLMAKALLLYGA
DIESKNKH-G---LTPLL------LGVHEQKQQVVK-FLIKKKAN--------LNAL---
-DRYGR-------TV-LILAVC--CGS-A-SIVSL-------------------------
--LL-EQN-IDV--------SSQD------LSG-QTARE---YA-VS---SRH---NV--
--ICQLLSDYKEKQILKVSSEN--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------SNPEQ-----------
---------DLKLTSEE------------------ESQ------------RLK-------
--------------------------------GSENS-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------QPE--------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------EMSQEPEINK-----------
---GGDRKVE--------------------------------------------------
---------EEM------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------K--KHG--STHMG------------
-------------F-------------------PENLPNGATADNGD-------------
--DGLIP----PRKSRTP---ESQ-----QFPD-TENEQ--Y-HS---------------
------------------------------------------------------------
------------DEQNDTQKQLSEEQNTGILQDEIL-----IH---E--EKQIEVAE---
-N-EF-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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-----------------------------

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--------------------------------------MNRF--PN--KPGVDL-GPTSD
-DEV--------------------------------------------------------
------------------------------------------------------------
--------------------------------L-DFKTKEGATKSELVAEK---------
---SDTDIID----RAPQEQT--------------NHDHLS-------------SVDGAH
KNT----RSDMLSALGLGEEEDIESPQDSESI-SESLPQKYVD--H-------------L
SGTA--------------------------------------------------GE----
------------------------------------------------------------
-------------------------------------------RG-----KKTLNVQV--
ED---VSNI------PS---CMSGSRNFKMAK------L--E------------------
------------------------------------------------------------
------------------------------------------------------------
----EPRHVGKPV---------------AHMDS---------------------------
----PEKY----------------------------------------------------
------------------------------------------------------------
------PNVKPAVRMK------NYVPNKTV------------------------------
--------RMK-------------------------------------------------
------------------------------------------------------------
----DLQT-------------SGS----ELS-----TKLD-LEMI-SEE-----------
----------------------------------EQ-EN-L---G-D-------------
--------------------------------------ENNHSQ-IEEEKKH---KSSEV
EVSD-----------NVCNAA---------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------DESGL-IQQR----------
--KSGG------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------NSNQEFPATENEDS---------------
-------DS--SNPGVHKKE-VKKKNND--KRTPEECVIAPVF-----------EK----
----------------------TDSLTGGLL-----------------------------
-----------------------------------HV--NDDS----I------------
------------------------------------------------------------
----------------LREVDQDD---DRPARKTPYEKKK---VKEQMNYVN--------
------------------------------------------------------DL-DDL
TQSSEMVSEDGDAL--C--STNSTLQAEPLD---LG--CE--DSGSLLKIQDA----IFS
HDRLVDF---QRKH-------------------CELLRGEIHRMKSK-------------
--FCELQ----KELSETK---EVKSQLEHQKVE-WEQEH--RSLRFTLKQEEENRRNANM
LY-EKIREQ----LRRNEDK------------------YSKEVEMKQQLELSLRALEMEL
KTVTNNQS-QLTYIFNFS---LSRIIIANELIDENL-----CMKFNL--FKSIK------
--FKEKPLQSE-ASAGPEEPKD---LLCK------NQMLQDEIAMLKLEIDTVKNQNLEK
EKNYFEDIEIVKAKNDDAQKAIKLNEERLT--------KTISQYTGQLNVL-TA------
ENTMLKSK-----------------------------------LENEKENK---------
--QRLETEVESYRSRLAGAFHDH--DQDQTSQRDLE----LAFQKAKDEWLCLQDKMKSD
VANLKEKNEALS--------------------------Q-QLSSAESKFHQ--VKIKLQH
TR-DNLREKTLM-LER--VQRDL--RQAECQKQE-----TEHMYQN-EQGKV------NK
YLGKQDSLEEALSQLQSENILLRQQLDDTQNKA---NSKEKTDISIQD----QFQQIVRK
LHAEN-EKQGLMLEERNKELIQER-NHLKERMYQYENEKTEREA--VVRQLQQELADA--
--LQKK------SMSEASLEIMSSYLAKLEAETQDFKNNLHQPTSQ-YISKAWRFSDDVY
CSEK-----------------------------------CMDHLCKLLG-----------
----------------DGISLS--------------------------------------
------------------------------------LQ-IISLW---IAIQEAFINLALG
KIEK---YYCRTIKEYRIKCKCCLTKMRVKNIFCESWCNPWSYILQYT------YHPAV-
---L-NLHSSLPN--------SLIFFLKSDDFPAELETASSKCLHMDAE-----------
-KS-------SISTEGMQRKCEKTRE-EKKLEQDLVTLKSHMNEYEM-NMIGHSQVEQY-
QQTTEERVRQNL-KQRNEKKST---YLCRTDA-ILLNYSK-VVSFNFIQAGSQQMELRIK
DLESEL-SKMKTLQEDS------NKAELEKYK----HLYLVELEVRKSLQ-NKLDKTDER
LIETRAELEVEKQQ---NRSIHS------TLSTRPVLESSSVGNFNPASGFNTNVISRAN
RRF-STSIPCPSNDS-METYLTKMQQELDRSITREIRKV-DAE-----FAS-----D---
--------------------AFTVSQVS-A---------DGS----NVYDDQILKTKAQY
TQILKEK--FMI------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

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-------------------------SLSSSFDYRHASLCIILL-LIFYIFIIDLKC----
--ILPFS--LI--------------D-VGSSDESAVS-IF---HDLCVDSLPASDDEDLS
VATKHCVLEKVSEPLPGLSHEKGNRILNGKGEG---------------PPA---------
KRPSLKPSTEMEDP--AVK----GA-VQ------RE--CSDIEKDLLV-------ASEEE
RERLERS---EKKQ------------------------PQVKEGNNTNKSEKIQLSERLC
DCTSAAA---AGRLTQQRKIGKTYSQQF-------PKEVKEEHDKYTLKQENEEKANKGK
KL-KK---------------------------------EVVRKKNK-QLEPTVQSLEMKP
KTVRNTPN----------------------------------------------------
----------Q-DFRNHEEMKD---LMDE------NCILKTGVAILRQEICTMKRDNLEK
ENKCLTDIKIVKEINAYLEKSVKLNEETIT--------KTTFQYEQELHDL-KA------
ENTGLNSK-----------------------------------LLKEKESK---------
--ARLEAEIESYQARLAAAISKH--SESVKTERNLR----LALERTQDV--SLQVKMTSD
ISEVEDENEFLT--------------------------E--LSKMQIKLIT--LKDKFRK
TR-DTLRKKSLA-LET--VQNNL--SPTQQHIKE-----MKEMYQN-AEAKV------SK
STGKWNCVEERICQLQRENPWLEQQLDDVHQKE----GDQEIVINIHR----GS------
--IES-GKKDLLLQEKNK-QMNEC-NHLKENVFQYEKEKTKNKY----------FQTS--
--GKII------------------------------------------------------
------------------------------------------------------------
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-----------------------------

------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------EGTHSGYH
ICRRDLKK-----IHK---------------AAYVGDV----------------------
RK---VQRVLFLR-QNG--LD-EPDRK------------------NRTAL----------
----------HLAC--ASGHGGVVALLLERGCQVNT--QDRKKRTALIK-----------
-AVQCEAEECTDILL-KSGANVNAADVL----GN--TVLHYAI-LNK--HIAAKLLSHAA
DMDVKNQD-D---LTPLL------VAMRE-NRQMAE-FLNEKQAN--------IHAI---
-EKMKS-------NH-QW------------------------------------------
--IS-EHK-DEK--------RHEM-------------------P-FQ---DTN---PV--
------------------------------------------------------------
-------------------------------------------GT------S--------
--------F---------------KMTL----------A---------------------
------------------------------------------KGTAA--EEAE-------
-VR-----HPVSRISP--K--------------HDID---D---SRPPSDD-----DL--
-----------DLARKE-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------EATKPKTGGK------E---
---NGARTIN----SVLKEQA---DHSID-------------------------------
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-----------------------------

------------------MNKLFSFWKRKN------------------------------
--------------------------------------------------------ETH-
-------------------------------------------------------SQGYN
LREKDLKK-----LHR---------------AAAVGDL----------------------
KK---LKEYLQLKK-YD--VN-MQDKK------------------YRTPL----------
----------HLAC--VNGHRDVVLFLIEQQCKINI--RDSENKSPLIK-----------
-AVQCQNEDCATILL-NCGADPNLRDIH----YN--TALHYAV-CGQSVSLVEQLLDYEA
DLEMKNKD-G---YTPLL------AAVVSNNPKMVK-FLLEKGAD--------VNAS---
-DNYQR-------TA-LILAVS--GEPT--RLVNL-------------------------
--LL-QQG-VEL--------SCQD------ICG-FTAEE---YA-YF---NGF---TV--
--YPQFTASHGKKKHV--K-----------------------------------------
------------------------------------------------------------
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-----------------------------

------------------------------------------------------------
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-------------------------------------------------------GPGYH
IKYQDLRK-----IHR---------------AVVADDP----------------------
RKLQDVEQFLLFDL-CD--IN-ERDRK------------------NRTAL----------
----------HLAC--AIGRVDVVKYLLAWKCDVNL--RDGENRTALVK-----------
-AVQCQKEACVDILL-KKGADPNAKDFK----GN--TALHYAA-FEGNILIAQKLLFNKG
EIEAKNKD-G---LTPLL------VAVNEKKEKMVA-FLL-EEAN--------INAV---
-DYTKS-------TM-SMLAVQ--SQDE--ACVDI-------------------------
--LL-KHG-ANP--------DLKD------IKG-NTALH---YA-AL---GDN---VT--
--IAQK--LL---------LKKV-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------N--------------
----------ME--IR--N-------------------------K---------------
------------------------------------------------------------
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-----------------------------

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-------------------------------------MLQEEIARLRLEIDALKNWNQQK
EKNFLEDIKILKEKNDFLQNALMLKEETFA--------TMIFQDSIQPEIL-KA------
ENEMPSFK-----------------------------------LKDKSQNQ---------
--ERLEREIESYRCRLAAALQDR--DQSQASKRDVE----CDFQRTREEWFHLKEKMNFD
MSDLKGKNELLS--------------------------E-KLSNAENKIRS--LKMKWHQ
TK-DALREKTLV-LED--VQRDL--TQLQCRRKE-----IEQMFQN-EEDKV------SK
YIQKQESLEERLSQIQNENLLLRQQLDEAYKKA---DNQEETIINIQE----QFNAIFKN
-QAQS-EEQSLLLEQKNNNLINKC-DFIKKRLYKYEKEKAERNV--SIEKEN--------
------------------------------------IFQTS-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------MRKLFSFGRRLG------------------------------
--------------------------------------------------------QALL
DS----------------------------------------------MD-QEYAGRGYH
IRDWELRK-----IHR---------------AAIKGDA----------------------
AE---VEHCLTRRF-RD--LD-ARDRK------------------DRTVL----------
----------HLTC--AHGRVEVVTLLLSRRCQINI--CDRLNRTPLMK-----------
-AVHCQEEACAIILL-EHGANPNIKDIY----SN--TALHYAV-YNKGTSLAEKLLFHHA
NIETLNEE-G---NTPLL------FAINSRRQQIVE-FLLKNQAN--------VHAV---
-DNFRR-------TA-LMLAVQ--HNSS--SIVSL-------------------------
--LL-QQN-INI--------FSQD------LFG-QTAED---YA-VC---YNF---RR--
--NSSYEALNFE------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------K--------------
------------------------------------------------------------
-------------K-----------------------------TR-------R-------
-----------------------------CK----------SL-----------------
------------------------------------------------------------
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-----------------------------

------------------MKKIFGFRS-KG------------------------------
--------------------------------------------------------PSPL
GPSA----------------RPRSNCVGFGR----------------EGA-SGSLTPRYH
IHDKDMGK-----IHK---------------AASAGDV----------------------
AK---VQHILILGK-SG--VN-DRDKK------------------DRTAL----------
----------HLAC--AYGHPEVVTLLVERKCEIDA--RDGENSTALIK-----------
-AVQCQEEECATILL-EHGADPNVMDSS----GN--TALHYAV-CSENTSIAARLLAHNA
NMEAKNKD-D---LTPLL------LAVKEKKQHIVE-FLVKKKAS--------IHAV---
-DQLGS-------N--RQIFEY--DGRR---LK-SSENSNPVDNGSED------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------ESLTRSSN--TPDP--------------A----D--SWPTSDE---------
--------DEYNFDSKN-------------------VPKINLTELWAAAQQSKKN----Q
TKCGFENL------------------ENRILFDNSNSNSE--------------------
---------------------I-------------------EDAV---------------
------------------------------------------------------------
-----------------------------EIGPG--------------------------
----------------------------------TSARVQTS-SLS--CQSPDP------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------MEGATEPATGREEN--------
--ENGADAVE----RASQE--------------QPNGDN-------------LTCAGGWH
RSN----KSEMMSALGLGEDEEEESPWDSESI-SDSVSLKGVG---------------HL
SGTADQTGETKVHG---Q------DED----------------------------VTYIP
SCMSGSRNFKMAKLEESRNV--------------GIPVAHKGMK-KKKTKLPT----IKR
-MDPVLYK-----------------------------TVGMK------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------DVPT----------------
--------------------------------------------F---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------KS
EPDIEIVPREEQRRLSS-------------SEDSQRQV---------EEKRNYK------
---------------------------TSEAKVS---GSLCDGSVDSV------------
------GNGVNQ-----------QSGKTD----NQQLPLKRHEER-----------D---
-----------SGPALLMKE-VKKKES--EKRVPRESVLMPVTEEAGSP-----------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------PGGSSQMQDGSSLSD-
-------------------TDHSEM---RPIKKTSNKNNK---VRKQVAAVD--------
------------------------------------------------------DL-DDL
NESSETASEDCELQ--CPDYESVLCEIEHLR---ME--CRD--IVSLLKIRDA----VYS
YKRLIEF---KKSH-------------------CELLTGKLKRMENK-------------
--FKESQ----KEISETK---EVRSQLEHEKVE-WEQEL--SNLRFALKQEEEKRRSADQ
LS-EKTMDQ----LRRKDEQ------------------YQNEVDEKQQLEVSLRTLDMEL
KTVRNHLN-QVLEERNEIQRQLSREQNARMLQDGIL-----ANHLSK--QKEIEMAQ---
-KKMTSEVSV-----SQEKEKD---LLHK------NQRLQDEIAMLRLEMDTVKTHSQEK
EKKYLEDIKTANEKSDKLQRMIKLNEETFT--------KTIFQYNGQINNL-T------T
ENTMLSSK-----------------------------------LENEKQNK---------
--ERLETDIESFRSRLASAMHDH--AEIQTSKRDLE----IAFQRARDEWVRLQDKMNFD
MSNLRDNNEILS--------------------------Q-QLSKTEKKLNS--LEIEFHH
TK-DALREKTLA-LKH--VQRDL--NQTQCQMKE-----VEHMYQD-EQGKV------NK
YMGKQESIEERLSQLQSENMLLRQQLDDASNKA---DSKDKTIVDIQD----QFHDMLSR
LQAES-QKHRLLLEDRNKELVSEC-SHLKERMCQYENEKAER EV--IVRQLQQELADT--
--LKKQ------SMSEASLEVSSRYRSNLEDEARDLKKKLGQIRNQ-LQEAQDQHREAVQ
R-----------------------------------AEKTQDHLQKLELENSNFKITIQK
QTEEIEQLQ----ENLSSV-----------------------------------------
------------------------------NLSEEDKE-KLKKL---AELKESLEYT-LD
QEQKKNDALEKELTEFKEL-----LQMTK--------------KELNE------HENR--
--EL-NHNQDSKNSQFEMDISVNMLINKIDDLTTKLETASSKCLHLGKK-----------
-NQVL--QQELLLMKSIQKKCVKLEKHKKRLEEEVDRLRSH---MEK-HMVEHSQVQQY-
QREVEERARQDL-VEKLKQVNL---FLQAQAA-SQENLEQ-LREN-SNASV RTQMELRIK
DLESQL-SRMKT-QE------DFDKIELEKYK----QLYQEEFQVRKLLS-SKLSKTNER
LEEASTKLHLEEQQ---NRSLLS------SLSTRPVVECPCVGSLHNSLVFNRALIPREN
IVI-PTSSLQPSNKR-MEIYLTKMHQELEKSINRELKEA-AAE-----LES-----E---
--------------------FCRVSPLGSA---------TKP------SQDLLSEASQEY
IDILKKK--YTIC-----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------MRKLFSFGRRLG------------------------------
--------------------------------------------------------QALL
SS----------------------------------------------RD-EEYAGPGYH
IRDWELRK-----IHR---------------AAIKGNA----------------------
AE---VERCL-RRF-RD--VD-ARDRK------------------DRTVL----------
----------HLAS--AHGRVEVVTLLLSRSCQIDI--CDRLNRTPLMK-----------
-AIHCQEEACAIILL-ERGANPNIKDIY----GN--TALHYAV-YSKGTSLAEKLLSHHA
NIEALNEE-G---NTPLL------LAINSTRQQMVE-FLLKNQAN--------IHAV---
-DNFRR-------TA-LMLAVQ--HNSS--SIVSI-------------------------
--LL-QQN-VNI--------FSQD------VFG-HTAED---YA-VC---CDL---RR--
--YMLILG----------------------------------------------------
------------------------------------------------------------
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-----------------------------

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---------------------------------------------------------MIF
---------SAEQVLAVI-SE--------------E---------EQ--ERLEE------
----SENNELQ-ISHGHKKEKD---LLHE------NCMLQEEIARLRLEIDTVKNLNQQK
EKNYLEDIKIVKEKNDFLQNTLKLNEETFT--------TTIFQYSVRPEVL-KA------
ENKMLSFK-----------------------------------LEDENQNQ---------
--ERLETEIESYRCRLATAVQDC--DQ--ESKRDVE----ADFPRTRQEGFHLKEKMN--
------KNEMLS--------------------------E-KLFNAENKIRS--LKMKWHH
TK-DTLREKTLV-LED--VQRDP--TQSQCQRKE-----IEQTFQN-EQDKM------SK
YIQKQDSLEERLSQIQNENLLLRQLLDEAHKTP---DNQEETIINIQE----AFNAIVKN
-QAQS-EEQSLLLEQENNKLINKC-NYIKKRLYKYEKEKAERNV--SIEKEN--------
------------------------------------ILKL--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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-----------------------------

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------------------------------------------------------------
--MAS---------------RGGEKRGGSEGSPKPTVSAMRKTPSV--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------GSVRSQEDQL-
----------SLSYQGDRWSSDSSWLSDS--AG-SDS--------H-------------V
EGAL--------------------------------------------------DQP---
-----QHDVCLEDPCEPHRA--------------ARSGD-------VP-----GVERVLA
PGD-----------------------------------PGVNKRD-RKESLWHLIPECKM
EQSPESLPQNNNPDWHPTNLTVSDKTCQKSKILSVDDQCPSVSPSMPENQSAAKELGQMN
LTEQEKM----------N---------------------VLGNGSLH--DLC-QSQLPE-
----------------------NKESK---------------E------AEQDLELTSEE
E---QERLKGHENKQPQ----KMSQEPEMAKDCDRED------------------IPVYS
ILPHAQKSEEMWIEQGKLEWKNKLKL-----------VTNELKQRFGE------------
------IRETYKIP----------------------------------------------
----VCPEEEPLLDNSMRKTNVKDIPFNLTN-N-------------------------IP
GCVEEDASEVSVSVVFETFPEQNEPSLKSIIH---------PYFHPYSGSLQHACQSSSK
LHLHEKKLDCDSDNKPGVEHIFSMDEN-FSNDAGTKKAR-NPEEVTVEMKE-----D---
QEF-DLQMTKNMNQNSDSC-----------------------------------------
---------------------------STNNYKSLKPKL-E--NL-SSLPPDSYRTSEVY
LHEELQ---QDMQKPKTEVDRVEEMF-----LALKKENVQLQKEVEEEVEKQ---RSNST
ELSG-----------NPAHGAAAG------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------NNDDGL-NQQ-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------FPRKK-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------KKGH-DRPADKTSNEKNK---VKNQVH-----------
---------------------------------------------------PEADF-ADS
VGPSETTSEDCELS--HSTYENFLLLIEQLG---ME--CKD--SVSLSRIQDT----FCF
YEHLLKL---KNND-------------------YEQLTVKIKQTENM-------------
--VSVLQ----KELSETK---KTELQLELQKIE-LEKQL--YSLRLALKQEKEEKGNAVM
LY-NKYSER----LRLKEEE------------------CGKEVEMKQRLKWTLRRLVKEL
KTVRNNLD-LVVQERNDVQKQLSEEQNARILQDQIL-----TS---K--QKELE------
--IAQKKINSE-ISHRHKKEKD---LLHE------NCMLQEEIALLRLEIDTVNNQNQQK
EKKYFEDIEVVKEKNDNLQKIIKLNEEKLT--------KTILQYSGQLNDL-TA------
ENKILNSE-----------------------------------LENKKQNQ---------
--ERLEIEMESYRCRLAAALRDC--DQSQT-SRDPK----LDFQRTRQEWVHLQDKKNVD
MSDLQAKTEILS--------------------------E-KLSNAESKISS--LQIQLHN
TR-DAVERKSLI-LER--LQRDL--SQTHCEKKE-----IEQMYQT-EQRKL------KK
YIAKQESVEERLSQLQNENTLLPQQLDDAHKKA---NSQEKTISTIQD----QFHAFAKN
LQAES-EKKILSLQEKNKELMDEY-NHLQERMHQCEKEKAR RKV----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------DLIEAQETAPLRCLHLDAE-----------
-NEVLQLQQTLFSMKAIRKQCETLQKNKKQLKREVVNLKSY---MER-NMLECVEAEQH-
KLLIEEKAKKDI-AEKLNEAIL---TLQKQAAVSQEQLAQ-LRED-NTTSV KTQMELTIK
NLESEI-SRINTSSADF------NKTELERYK----ELYLEEVKVRESLS-NELNRTNEK
IAEVSAQLTVEKELTR---SPFA------ACSTRPILEPPCAGNLNDSEDLNRKHIPRKK
KSA---------PES-MESYLLKMQQKFQNDITREVTAA-TKCEPEPYVAS-----P---
----------------------PESA-----------------YQKNLNQDPVLEATKEY
AQILSRK--YMI------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------MKKLFSFRKKGK------------------------------
--------------------------------------------------------TDQS
-------------------HSYFSDL-----SV----------SGASPT-PSLSTGGRHR
RQDKHSKK-----LHK---------------AASVGNV----------------------
QK---LKVYLERRK-HD--VN-GQDKR------------------NRTPL----------
----------HLAC--ANGYANIVSLLIENHCKINV--QDSKNRTPLMK-----------
-AVQCQQENCATILL-QHGANPNLVDFY----NN--TALHYAA-CGKNISLAKKLLGYKA
NLEAKNKD-G---YTPLL------LAIAENNENMVK-FLLKKGAD--------VNAS---
-DNKHR-------TA-IMIALI--AEPT--SSVTL-------------------------
--LL-QQN-TDL--------TCKD------IYG-FTAEE---YA-SF---NAF---TT--
--FHQILANNGNKKKT--KSTAY-------------------------------------
------------------------------------------------------------
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-----------------------------

------------------MKKIFGFGRKKK------------------------------
--------------------------------------------------------GDPP
PGST---------------------------------------------A-SPCPAGAYE
LRQKELGK-----LHR---------------AAAAGDL----------------------
AQ---VRQG--LKK-HG--ID-GRDKA------------------QRTPL----------
----------HLAC--ANGHADVVTFLVESKCKLNL--FDNDNRSPLMK-----------
-AVQCQQEKCVAILL-EHGADPNLADAN----GN--TALHLAA-VAPNTFLAGMLIEHNA
HIDAQNKE-G---CTPLT------LAVSEHHQEMVE-LLLKKGAD--------VNAR---
-DLCER-------TP-LMTAAS--GGEL-----------------------------KVV
KVLL-RYG-ADL--------SHKD------TNG-WTAED---YA-II---HGY---DS--
--LSNQLAEYADWENTGEASAGA-------------------------------------
TRGISVPMTPHKARAAG-------------------------------------------
------FTLGAPA----VDRG---------------GT--QQ------SPKQT-------
-------P----------------------------------------------RTGESR
KAIDDFSQGDSIRSSE--KEGS--------------N----D--SWHTSEE---------
--------EELDFTPKK-------------------PQKPNLTMLMNVSKKFRNIGGGDS
SRIESPKSQKKSLQQKEPTDANLNKGECGELLNQDVSDSSNLEEDELEEEEEEEEDENDD
GDDDEEYEEEEEEDLTPDEKEE-------------------EDLEDE-------------
------------------------------------------------------------
---------ETQSNDIMEEEQ------RGKIEPKEEINQ-------NLE----YLSNVKN
EGDAQCG------------AGSVSSDYQKTCKKTDEKMEESVDTPV--SFIDGCYERLQE
NITAMSPKRMNNEVSYESVPKQAVLQNLNNLQDKQESCNKKSMIQKLFHRNTASCFADSE
MTDLKKEIPQPLSNSGDLQEEKLSFSDGFKSSSGSWSAAENIKLENQRPSSVTDDEDTEE
GQYKEVDNKVHEALKQEGENLCLNRCEENLRATFSSSTKEESPKWEEEEEQ---------
EKEDTGEKLQ----TTVFE--------------GVKNSVCS--------INHQVHNASED
TAN----ERSTLPAIGAQQEKESESPWDSEMD-SESLRKASP-G--------------VL
LPAADEHGICLQNISGEH------NNG----------------------------FSEKP
SNLQLKVSASLLEMNETSPKKEGQKSDLREELSLGDVDDIEGECSESVFHVPSSAEKGMV
-KDAIENY-------------------------------GRR------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------DKCVL-------------E-
-----TTSLIEKTAYEKQT----DKAEISHQETLAENEESHSADKQLSLKPWEERYERMW
--------------VEKEKRELKTNF-----KNITAELKQLFGEINES------------
EKATSLVAE-----------VSED-------------------DFNE-ELKSFR------
VSSCATESSNK--LESKGE----------FGDM------KLNV-------DLKEPKTEIV
IPSLGVLPDH--------------------------------NNLNANVENTWSTDE---
--------------EDCTNYTD-----NTN-------VPLAKGEEME----------ENE
NGISKSVEGSPEYSPRYCL-KTNILDDISSILPKVRPISTNDGST-LDFIREKKFGKDVC
LSDSVSRDCFIKNKEIGEKEIENLFPHAQQPCGM-L----------------------KR
NLDEELK--QDVERFKSKVGMLQMVFLALEKEKVQLQKE---VE---KEKRKQK------
---------------------------HFKVQAV---EKQEDLD----------------
--KLNTPAGNITNQPVKEKLALRKNEKMTEEKHTKNFSSEERPKL-----------VE--
-------MPIKGKSVLNAKG-MKKNEK--KRQSS------------KQ------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------RANRKIQLMDDSTFSE-
-------------------TSQDEE---RPATKTGSEKNK---GSMQMDVTD--------
-------------------------------------------------------D-LDL
TQSSDTTTEDAELP--TSTYKEAMLLFEQLS---VD--HTD--SAILLKIQNI----LLE
YEQIIDC---EKKR-------------------YTALWREVKKLESE-------------
--KEESQ----LIAEETQ---DLKSILAHQEME-LKSDI--QSLKFSLKQEEEKRLRAEM
QY-EKMREQ----LRRKEDQ------------------YCRETEERQQLELHARNLETEL
ITLRKLMK-QIEEERDETQRQLSQEKSARALQEGIL-----NSHLWR--QKELEEET---
-RKTIGKNSE--ESDTNDREKD---LLHR------NQLLQEEIAMLRLELDQVKLRHQEN
EGKYLEENESLKEKNDDLQKELKLNEEALT--------QTVLQYNGQLNLL-K------T
ESAMLTSK-----------------------------------LEQTKESK---------
--DRLETEIESFRSRLNAAVQDL--ERHQSLKSDVE----RTFQRERDEWLRLQDKLHCE
LSDVRETNKSLS--------------------------Q-QLSKMESKANS--LENELHQ
FK-QTLREKTLL-LEM--TQKDL--NQAQCQAKE-----SDHARQL-EKDQV------SK
FMIKQESMQERLAQLQSENLLLRQQLEDMQNKG---IIKEKVVNDVQD----KFNDIFNK
LRADT-EKQVYLMEERNKELNTKC-TDLREQVFKYETDKVER E--GMVRQLQQELADA--
--LKKQ------SMSEASLEVTTRYRSDLEEDKLRLQKELDRVKTK-LQESEEQRIQSEH
CVHDLKTVLDNKEREVSASSQKLQDLLLATSGTNTTIKQLEEHVQRLEIENARLEAAAKQ
QTNRIEALQ----KDLQASTSVHNRLEDLITGLRTAQTAAEEYQHQQMQKQNMLAMTSKD
SRNMWEEELKSRAHLEDRLAQLDREKAELLEQCESERK-KVKKL---VELKRPVEAR-LD
QEMKRNIELQKECHRCKRL-----LNRAV--------------KKLRM------YEARER
ESQF-NFQGEMKNRYSEMVNEVGKLRTKVTELSQQLELESKKCIQLEAQ-----------
-NQDL--REELSALR---ENHEKLEKSKCQLKEEVANLRHH---LEA-NMVNHSQIEQY-
KKEMEERAGQEI-RQKLQEVNL---FLQTQAA-SQDRLEQ-IRAN-HHASL RNQLKHRIK
DLECEL-DRIKNTQQDSIFQKESTQAEVEKYK----EMYLEEMKIRRSLA-NKLERANER
LAEANAKLLQERHR---SKSLIASSIVTGGLSASPVLYSTELGHLGNNLALNRSLSLGGS
FLG-TAGNALSSRNK-VEAYMAKIRKELDEKITKELEQA-TAE-----LET-----G---
-------------------S-AGASPMVST---------DGSSRNLNVDQDPLCRAIQEY
RDVLTKN--YLI------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------MKKIFGFWNKKDRETPVT------------------------
------------------------------------------------------S-----
------------------TR--LRREN-------------LRLG---EEKESVNAQPGYN
IQDKDLGK-----IHK---------------AANEGNV----------------------
AR---VQQILLLGK-NG--VN-DRDRR------------------NRXXX----------
----------XXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXXX-----XX--X-
-XXXXXXX-XXXXXX--XXXX--XX-XX----XX--XXXXXXX-XXXXXXXXXXXXXXXX
XXXXXXXE-D---FTPVL------LAISESNEQMVE-FLVKLGAN--------IHAV---
-DKIKS-------HC-QMISDF--REKR----SKNTSPGN--------------------
---------Y----------PXXX------XX----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------XXXXXXLSD--KPGI------------------DE--SWPTSDDED-------
----------LDFSIKN-----GPR--------------PNLAKLMSAIH----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------QSRTYIE---ETPSIVRP
ESKTLFEESH----------FDSEDEDVVETLPKPSFRAQGFSHSA--FRSTDP-PLKSS
SSFS--------------------------------------------------------
------------------------------------------------------------
--------------------------------SVSGATKEGATKAAFETRE---------
---SVLDT-A----CAPGEQR--------------KNDTLS-------------CEDGAD
RKN----RNDKMSALGLGEEKDEESPWDSESI-SERLPQKYTG--H-------------V
SEAA--------------------------------------------------DQ----
------------------------------------------------------------
-------------------------------------------KE-----ENTFSGQI--
ED---VLCV------VS---CMTGSRNIPIAE------LEDT------------------
------------------------------------------------------------
------------------------------------------------------------
------RNTGLSV----------------------------------------------A
YLESPEKY----------------------------------------------------
------------------------------------------------------------
------SHLKPRTEMK------DSAPDEAT------------------------------
--------GLK-------------------------------------------------
------------------------------------------------------------
----DVRTSKSA------------------------E--RELKMTLVE------------
------------------------------------------------------------
------------------------E-------QERPDKRANKSQVEKKGKQF---KSNEL
EVAE-----------HMQD-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------PVAGNGADGL-IQQG----------
--KSGK------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------TDTQQFSTKETGDT---------------
-------DS--SDPALHMKD-LKKYESE--KCASKESAMTPVL-----------QK----
----------------------VPALTGVL------------------------------
-----------------------------------QG--SDDA----G------------
------------------------------------------------------------
----------------RTETGQGE---GRAAEKTSEEKIK---VQKQINSTD--------
------------------------------------------------------DP-DDS
SQPSE--------P--SHGFRNCVLLIEPLG---ME--CK--DSARLLKVRDV----IHS
RRRLAER---ERSC-------------------CEQLTCKIEKMESK-------------
--ASALR----KELSEMI---EIKSQLECQNME-MKKEV--HNLRFTLKEEKQKRTHSSK
LL-QKNRKQ----LRRIEEQ------------------YSKEAELKQH---TLQALAMQS
KTVRSDLN-QVVEERNDAQRQLSRERNDRMLQDGIL-----TIQLCR--QEKQM------
-AQKNTMQNSE-VSSSNKKEED---LLHE------NHMLQDEIARLTLERDTIKNQNLEK
EKKYSEDIAILKERNDD-QKTLKQNEETST--------KAILQYSGQIDVL-KA------
ENTTLNSE-----------------------------------LENERQNN---------
--KRIEKEAESYRSRLAAAVRGL--NRGQTLRRDVE----CAFDKATEEWDHVMARMASD
VSNLLGVCTKVS--------------------------K-AASKTERNFCS--LEIELHH
TK-EALREKTLI-LES--VQREL--NEKECQMKA-----IEHMYQN-EHGKV------NK
SIAKQQSIEEQLSQLQSENMLLRQQLDDARNKA---NNKE----NIED----QLPDMVKQ
LRAEN-ENQNLRLEERHKELFEEC-NRLKEWLYXXXXXXXXXXA--VVRQLQQELADT--
--LKKQ------SMSEASLEVTSRYRINLEDEIQDLKKKLHQIRCR-XXXXXXXXXXXXX
XXXX-----------------------------------XXXXXXXVEIENAELKVTVKK
QTEKIEQFQ----KNLLGTCLSE-------------------------------------
-------------------------------DE---KE-QLKKL---TELKQSLEYR-LD
QEMKRNGELEKEIIGFKR-----LLKMTQ--------------KKITE------YENGE-
---L-SFHGDLKTNQIEMDIQVAMLKHKXXXXXXXXXXXXXXXXXXXXX-----------
-XXXX--XXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXX---XXX-XXXXXXXXXXXX
XXXXXXXXXXXX-XXXXXXXXX---XXXTQAA-SQEHSEQ-YGEK-NNNSVKSQLELRIK
DLESEI-FKMKTCQKDS------ERGELEKKQPHLALGYIVELEVKKDLP-DKLNNTNER
LVEISTKLPVEKQK---KTSLLS------SRVTHIVHEPACVADVLNSLVLNRSLAPRGN
LVI-PTYPL--SSNS-METCLIKVQQEFEKNSKELAESE-AEE-----------------
---------------------FGI----VS---------SNS----NLNEDPVLKESQEK
M--LRKNMSL--------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------MKKIFGFRS-KG------------------------------
--------------------------------------------------------PMPL
GPSA----------------RPRNNCVGFGR----------------ENA-SGSLMPRYH
IHDKDMGK-----IHK---------------AASVGDV----------------------
AK---VQHILILGK-SG--VN-DRDKK------------------DRTAL----------
----------HLAC--AYGHPEVVTLLVERKCDIDA--CDGENSTALIK-----------
-AVQCQEEECATILL-EHGADPNVTDNS----GN--TALHYAV-CSENTSIAAKLLAHNA
DMEAKNKD-D---LTPLL------LAVKENKQHIVE-FLVKKKAS--------IHAV---
-DQLGS-------N--RQIFEY--DGKR---LK-SSENSNPVDNGSED------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------ESLTRSSN--TPDP--------------A----D--SWPTSDE---------
--------DEYNFDSKN-------------------VPKINLTELWAAAQQSKKN----Q
TKCGFENL------------------GNRILFDNSNSNSD--------------------
---------------------I-------------------EDEV---------------
------------------------------------------------------------
-----------------------------EIGPG--------------------------
----------------------------------TSARVQTS-SPS--CPSPVP------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------MEGATEPAPGREENG-------
-----ADTVE----RASQE--------------QPNRDN-------------LTCAGGWH
RSN----KSEMMSALGLGEEEEEESPWDSESI-SDSVSLKGVG---------------HL
SGTADQTGETRKRG---Q------VED----------------------------VTYIP
SCMSGPRNFKMANLEESRNV--------------GIPVAHKEALRKYPVIEPT----SKR
-TDAVLNK-----------------------------TVGMK------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------GITV----------------
--------------------------------------------F---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------KS
EPDIEIVPREEEKRLSS-------------SEDSQRQA---------EEKRKYK------
---------------------------NSGAKVS---GSLYDGAVDSV------------
------GNGVNQ-----------QSGKTD----CQQFPVKRNEEH-----------A---
-----------SGPALLMKE-VKKKEN--EEWVSRESVMMPMTEEADSP-----------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------PGGSLQMQDGSSLSD-
-------------------TDQSDM---RSTKKTSKKNNK---ARKQVATVN--------
------------------------------------------------------DL-DDL
NESSETASEDCELQ--CPDYESVLCEIEHLR---ME--CRD--IVSLLKIRDA----VYS
YKRLIEF---KKSH-------------------CELLTGKLKRMENK-------------
--FKELQ----KEVSETK---EVKSQLEHEKVE-WEQEL--SNLRFALKQEEEKRRSADQ
LS-EKTMEQ----LRRKDEQ------------------YQNEVDEKQQLEVSLRTLDMEL
KTVRNHLN-QILEERNEIQRQLSQEQNARMLQDGIL-----ANHLSK--QKEIEMAQ---
-KKMTSEVSV-----SHEKEKD---LLHK------NQRLQDEIAMLRLEMNTVKTHSQEK
EKKYLEDIKTANEKSDKLQRMIKLNEETFT--------KTIFQYNGQINNL-T------T
ENTMLSSK-----------------------------------LENEKQNK---------
--ERLETDVESFRSRLASAMHDH--AEIQTSKRDLE----IAFQRARDEWVRLQDKMNFD
MSNLRDNNEILS--------------------------Q-QLSKTERKLNS--LENEFHH
TK-DALREKTLA-LKH--VQRDL--NQTQCQMKE-----VEHMYQD-EQGKV------TK
YMGKQESIEERLSQLQSENMLLRQQLDDASNKA---DSKDKTIVDIQD----QFHDVISR
LQAEG-QKHRLLLEDRNKELVSEC-SHLKERVCQYENEKAER EV--VVRQLQQELADT--
--LKKQ------SMSEASLEVSSRYRSNLEDEARDLKKKLSQIRNQ-LQEAQDQHREALH
R-----------------------------------AEKMQDHLQKLELENSKFKITIQK
QSEKIEQLQ----ENLSSV-----------------------------------------
------------------------------NLSEEDKE-KLKKL---AELKESLEYT-LD
QEQKKNDSLEKELTEFKEL-----LKMTK--------------KELNE------HENR--
--EL-NLNQDRKNSQFEMDISVNMLINKIDDLTSKLETASSKCLHLGKK-----------
-NQVL--QQELLLMKTVQKKCVKLEKSKRKLEEEVGRLRSH---MEE-NMLERSQVQQY-
QQEVEERARQDL-VEKLKQVNL---FLQAQAA-SQENLEQ-LREN-SNASV RSQMELRIK
DLESQL-SMMKI-QE------DFGKIELEKYK----QLYQEEFRVRKSLS-SKLNKTNER
LEEASTKLLWEEQQ---NRSLLS------SLSTRPVAECPCVGSLHNSLVFNRALIPREN
IVT-PTSSLQPSNKR-MEIYLTKLHQELEKSINRELKEA-TAE-----LES-----E---
--------------------FCRVSPLGSA---------TKP------GQDLLSEASQDY
IDILKRK--YTIC-----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------MKKIFGFWSKKSKE---T------------------------
--------------------------------------------------------QVTS
IWGR--------------KI----CVLG--K------------------RESINARPWYR
IQDRDLGK-----IHK---------------AASEGNV----------------------
AR---VQQILLLG-KNG--VN-DRDRR------------------NRXXXXXXXXXXXXX
XXXXXXX--------------------XXX-XXXXX---XXXXXXXXXX-----------
-AAQCREQECVSVLL-EHGANPNLVDIY----GN--TALHYAA-CGENVSMAANLLSHHA
NIEAKNEX-X---XXXXX------XXXXXXKQQMVE-FLVRRGAD--------IHAV---
-DKAKS-------YP-RVISDY--REKR--SKNAS-------------------------
--QD-NYP-KGT--------PDKS------PCL-AEGTA---SAKMD---ERS-DEEFLT
RLPNIPIM---------------------------------------DDEDFH-VSIKE-
GATKA--AVETREN---ILDTTSA------PREQRK---------------N--------
---------------------------------------DNE------------------
------------------------------------------------------------
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-----------------------------

--------------MFSTFKKLCCCKR--E------------------------------
---------------------------------------------------------PKT
PLGF--------------CDGPSTCKWSLAC--------------CDCS---QDRY---G
QSYDPDNK-----FHE---------------AVCMGKI----------------------
KV---VLHLLSKK-KFT--IN-DQDKG------------------KRTAL----------
----------HFAC--FYGHLHLVQFLLYNDCMINA--LDDQKATPLMK-----------
-AVQSWETKIVSVLL-DNGADPNCKDFN----GE--TALHQAV-YVNSPDIATCLLEYGA
EIEETTRD-G---FTPLL------LALRERKFLMVE-YLIKNGAN--------IHAW---
-DDYQR-------TA-LMYAVQ--CDSE--AIVKQ-------------------------
--LL-EKG-VDH--------SLKD------AFG-WSALQ---YA-VA---GKR---K---
--VRSLILDYEDSLLLGQHH-------------IFSG--------QLRTDFYSS------
------------------------------------------------------------
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-----------------------------

MEEEINY-------DSQTMN--I------P------------------------------
---------------------------------------------------------RRR
RWYT--------------HL--WRSCLGLRC--------------MH--PQKKKKYPLYL
IGYDPIGP-----LQR---------------AASVGDL----------------------
DT---TEKLIHSS-QHH--VD-ESDRR------------------KRTSL----------
----------HYAC--AHNHPDVVTLLLENNSSINI--RDDEGCTPLIK-----------
-ATQRDNVDCASVLL-THNADPNLIDSS----GN--TAFHHAI-SRGNIRIVKMLLEHNV
DIEAKTEY-G---LTPLQ------LATFEQKPEMVE-FLAAKCAK--------SSVT---
-PSWSP-------SP-TVSPCP--SSTS--PLSSL-------------------------
--GL-PVC-PNP--------GTSS------LSE-DRKSS---SA------RRI-------
-KL---------------------------------------------------------
STGSSAQRTEVKHVRFN-EEILYF------KEERPLSCEARPPGQLKSILKNT------V
--------------------------------------QYNTVNEKITRRTSLW------
------CSKAEDVR------------------YTSCIKVKCFSVKSSFL-----------
------------------------------------------------------------
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-----------------------------

------------------MRKIFGSRS-KG------------------------------
--------------------------------------------------------PSPL
APG-----------------RLRSNCVGFGR----------------EGA-ASSPQPRYP
VQDKDLGK-----IHK---------------AACAGDV----------------------
AK---VQHALILGK-SG--VN-DRDKK------------------DRTAL----------
----------HFAC--AFGHPEVVTLLVERKCEIDA--YDSESRTPLMK-----------
-AIQCQEEECATILL-EHGASPDVTDAS----GN--TALHYAV-YSDNASIAAKLLAHSA
NLEAKNKD-D---LTPLL------LAVKENKHHIMD-FLVKRKTK--------TYVA---
-DKLGR-------Y--SSVLSA--S----------------MDKS---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------S---------
--------EDGSLTGHN-------------------VPKVNLTELWTAAQQSRKN----Q
SKHGFGEL------------------ENRMVFNNSNSNSE--------------------
---------------------N-------------------EDAD---------------
------------------------------------------------------------
-----------------------------EVLPE--------------------------
----------------------------------TSVRAPSFSVPS--FQPLDP------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------TEETTEPAVRKEENGA------
-------NIE----SASRE--------------QPNNGS-------------VTNADETH
KNN----KSDMMSALGLGED--EESPWDSESV-SESPPLNCVG---------------HV
SLTADHKGESIVNG---Q------VED----------------------------VGYIP
SCMSGSRNL--AKLEDSRNV--------------GIPVAHMAYIKVRPYLNST----STK
-V----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------N---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------LS
EPDIE-MSSEEQRRLSG-------------SDSSQLQV---------EA-NQYK------
---------------------------GSDVELS---ENLHAGAPAVG------------
----ATDEGLSE-----------EGGKTD----GQQFPVKEKEEH-----------ER--
-------YGCGTCSA----------YI--QKWVITTSVHLI----CGIN-----------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------IWGYFEIV--------
------------------------------------FILQ---VRKQTCAVE--------
------------------------------------------------------DS-DDL
TQSSETASEDCELP--YPNYESILLLIEQLR---TE--CKD--IVSLLKVRDA----VHS
YRRLIEV---TKSH-------------------CELLRGKIKRMGCK-------------
--VSEVQ----KELSETK---EAKSQLEHEKVE-WEQEL--SSLRFALKQEGEKRRSADQ
LY-DKIMEQ----FRKKEEQ------------------YNKEVEVKQQLEISLRALDMEL
KTVKDNLN-QVVEERNETQRQLSREQNARLLQDGIL-----ANHLCK--QQEIETAQ---
-RRMTSEVSV-----SHEKEKD---LLHK------NYKLQDEIAMLRLEIDTIKNHNQEK
EKKYLEDIESANEKNENLQRAMKLKEETFT--------KTVFQYNRQFSVL-T------A
ENALLSSK-----------------------------------LENEKQNK---------
--ERLETEIESYRSRLASAVHDH--GESQTSKRDLE----IAFQRAKDEWCRLQDKMNFD
ISNLKDNNEVLS--------------------------Q-QLSKTERKFNS--LEIEFHH
AR-DALREKTLV-LKH--VQRDL--SQAQCQMKE-----VEHMYQN-EQGKV------NK
YIGKQESIEERLSLLHSENTLLRQQLDEAHSKV---DRKDKTVVNIQD----QFRDLMKK
LQAER-EKQNLMLEDRNKELINEC-NHLKERVHQYENEKTER EV--VVRELQQELADT--
--LKKQ------SMSEASLEITSHHRINLEEETRDLKKKLSQLGSQ-LQEARDQHAEAVR
C-----------------------------------TEKTQDQL--VELENSKLKTTVKK
QAGKIEQLQ----KNLLSI-----------------------------------------
------------------------------NLSEDDKE-QLKRL---TELKQSLECN-LG
EEQKKNEELEKELTGFKKL-----LKTAE--------------KKLNE------YESR--
--EL-SFRQDIKTSQLEMDIPINVLINKVDDLTAKLETTSSKYLHLDKR-----------
-NQLL--QQELLSMKTVQKKCEKLEKNKKKLEQEVVNLKSH---IEE-NMIEYGQVEHY-
KREVEERAKQDL-VEKLKQVNL---FLQTQAT-SQESLEQ-LREN-NNASI RNQMELRIK
DLESEL-AKMKA-QE------DFHKFELEKYK----QLHVEEFRIRKSLS-SKLNKTSEK
LEETSAKLLLEEQQ---NRSLLS------TLSTRPVVECPCIGNLHNGLVYKGSFLPREN
LVV-PSSNLQPSNKR-IENYLTQMQRELEKSITRELKEA-TAE-----LEC-----G---
--------------------FLRASPLGSA---------TKS------SPDLPSEESQEH
PDILMKK--YMIF-----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TAL----------
----------HVAC--ALGSKEAAELLLENYCLVNP--RDSFKRTPLIK-----------
-AVQCNNSNCSKLLL-ERGADPNAMDIH----GF--TALHYAV-HYDHRCLARLLINYKA
NMEAKDKF-G---QTPLM------LAENNKNLEMVE-LLTKNEDN--------INVV---
-ERMKY------------------------------------------------------
------------------------------------------------------------
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-----------------------------

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---------------------------------MGGKYSRMGR--RMPQGF---------
------------------------------------------------------------
---------------------------------------RGFSGL----C----------
--KCQKRN----------------------------------------------------
-----------------------------------------------LEETPLGFCDIKA
P-----------------------------------------------------------
-----------------R------------------------------------------
--------------------------N-----------------TLCF------------
--GT-RDPAYLDMAYFPDNDLHMAACAGDLPFVRLYLIY---------------------
----------------------------------FAV--LQDN---LTPLLLALREDRLK
MAEYLVRMKA----SVHAVDFQRRTSLMYAVRCDSSVMVNLLLQQGVDMNFKDFFGWTAL
RYAIEGDRELLKA--ISIKMRHGFPLSL-----------------LLLNIVLE---E---
L---------ASAIK---------------------------------------------
---EEKEI----------------KGIK-I--------GKGEVKL---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-----------------------------

------------------------------------------------------------
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------------------------------------------------------------
-------------------------------YFTLLSCTTPLNYFTGTPL----------
----------HLAC--ANGNSNIVSLLIEKQCKESV--WNGANRSPSTK-----------
-AVQRDKESCAAILL-EHSADPNLVDLD----GN--TALHYAA-CHPSISLVEKLLEHKA
NLEAQNKD-G---YTPLL------LAITENNAEMVE-FLLKRGAD--------VNAS---
-DKNQR-------TA-LMIALS--DEPS--SLVSL-------------------------
--LL-QQE-VDL--------SRQD------IMDSQLRNM---LP-SM---VLP---GR--
--YHQLTANYGKEIS---------------------------------------------
------------------------------------------------------------
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-----------------------------

----------------------MFDD----------------------------------
--------------------------------------------------------YKPE
RWPT--------------LKE----R---LR-------------------LDGFSFPEYR
IKLSHLRR-----IHR---------------AICYGRL----------------------
EK---LKY-LLLT-RSD--VN-KRDKK------------------ERTPL----------
----------HLAC--ATGQPDMVSLLVSARCELNV--YDREYRTPLIK-----------
-AVQLRQEVCATILL-KNGADPNIMDFF----GK--TALHYAV-YNEDTSMIETLLCYGA
DIEERGKC-E---YQPLL------LAVSRAKVNMVE-FLLKKNAN--------VNAV---
-DSLNR-------SA-LILAVT--LGEI--DIVIL-------------------------
--LLKQHN-IDV--------FFRD------AYG-KTAED---YA-IE---TQN---KV--
--IFGLISEYKREKTSEELPINS-----NPVSSQ----------------KQPALKATSE
KKDSVSNIATETKDGEKSGTGKNLNIWLS-------------------------------
---------S--------------------------------K-----------------
----------------------------NERAHFCCIFFLCRSLCRP------DNIAQP-
--------VTEDEFDL--ESEIISKLYIPKRKIISPKSIDDV--LPPVEECFDRSLYIPD
IVAQPVTKNEFDLESEV------------------E------------------------
---------------------------------------YSLEEK------------S--
------------------------------------------------------------
------------------------------------------------------------
-------------------------------LSA--------------------------
---------------------------T--------------GEEA--NVSPEQTPLF--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------THTVED
RDHISTRFLRSMDSLTSSEGSSEQPPLSTLTP-K--------------------------
----------------------------------------EADPSSKVAIRRKDS-----
------------------------------------PPPGKVSSEKQPALKVT----SDE
-KDSVSNI-----------------------------ATEIKDGQQSGTVSSQK------
------QPALKATSDKKDSLVNIATEI---------------------------------
-----------NDGQQSGTVS--------PQKQSAWKVISKKKVPVL--NI------ATR
IMAGR---KS--GTVSCQKQPALKATSDKED----------SVSNIATEIKDA-------
------QISGTVSSQKQPPLKAT---SDKKDSVSNIVTE-----------------IKDE
QQSGTVSSQKQPPLK------------ATSDK---KDSVSNIV-----------------
------------------------------------------------------------
------------------------------------------TEIKDEQQSGTVSSQKQP
ALKATSDKEDSISNIAT---EIKDAQICGT---------VTVESMKPTLF-----INYFV
------ISDEKDSVLN--------IATEIKDGQESGAVS----------S---QKQP---
-T---------L-------KATSDKED-SV-SNI-ATEIKDGQES-----G---TGNS--
-----ATS---------------DKEDSVSNIATEIKDGQESGTGN-------FATS---
-----------------DKEDS-VSNITTEIKDCHCNCV-PSQLSDEL---K---SVMNV
LI---------------------------------------------------------M
YPFCFSVSSQKPPAN---------------------------C-------------RV--
----------Y------------------ETYFFGD----------YFDSNSIQVTSDEK
VSVSNAA-TEIKDGQESGTGNS-----TTD----------IAISFPK----------E-K
G----K-EEVIYKQPA-----------LKATSDKEDSVSNITTKI-KD------------
KRTS---------LPQISDDKKDSVSNIAT-------E--I----------KDGQKSGTV
-----------------------------------SSQKQ--PAWKATSDKKDSVSNITT
------------------------EIKDGQISGTEKRNSLPQI-----------------
-----NQWGVHQMSPQK---------Q-------SAWKVIFKKKAPVLNIATRIMAGRK-
-------------------------------SGTEYPENLPTLKATIEN-----------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------KD-SVL-NAATKMKDVQTSTPA
EQDLEMV------SEGEQKRLEDYEN-NQPRVKNQIH---------SRDD----------
-------------------------------------------------------L-DDI
VQSSQIASE-DD--LLCCNCKKVILLVDQHE---MK--CKD--CVRLSKIKNA----FCF
CKRSIKL---KDNH-------------------CERLIVKIQKMKNK-------------
--FSVLQ----KRLSEKE---EIKSCLEHEKLE-CEQEL--CSVRFAIQQEKEKRRNAEE
LH-QKVREK----LRTTEEQ------------------HRIEVDVTEQVKLALKSLEMEL
KSVGKNS-----------------------------------------------------
---------NQ-ISDTDKK-ED---LLHE------NHLMEDEIATLRLEIDTIKNQNL--
EKKYLKDFEIMKRKHEDLQKTLKRNGETLA--------KTIADYSVQLAAL-T------D
ENATLRSK-----------------------------------LEKETQTR---------
--QRLETETESYRCRLNAPLSDH--DQSHSSERDQE----LAFQGTVDKWCHLQENSNSC
-------VLTLS--------------------------Q-QLSKAESKFRV--LETELHY
TR-EALKEKSLV-FEH--VQREL--NQKQCQMKD-----IEKMYKN-EYNKM------EK
CIEKQ----ERFCQLKKQNMLLQQQLDDALNKA---DNREKAILNIQA----RCDARVQN
FQAEC-RKHRLLLQEDSKRLVNEL-NHLKEKARQNEKEKAEREV--VVRQLQQKRNDV--
--LNKQ------SSTKALLDASSRHCVHLENEMQDSRKKLDRI-SQ-FQEIRDQLITTIR
C-----------------------------------TKETEGHVHKLEVENAMMRKTIKK
QDDQIERLE----KILQRS-----------------------------------------
------------------------------SLVII--------F---DLFQMLPVFR-K-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------VRKFFRLKRRKCAAPLDS------------------------
--------------------------------------------------------AGSQ
PWGQ--------------RGGAWD-------------------------TNPGTPDPRYQ
VREQDLGE-----IHK---------------AAWSGNV----------------------
RE---VQRLLSLG-RND--LD-EQDGH------------------SRTPL----------
----------HLAC--ANGQVGVVKVLVKRKCFLNL--CDRENRTALMK-----------
-AVQCQEEECVAVLL-ENGADPNVMDLD----GN--TALHYAT--SGDISIAEQLLSHGA
DVEARNKD-D---LTPLS------LAINENKEEMVA-FLMENKAD--------IRAV---
-DKAKS-------YR-EK------------------------------------------
--MD-KYK-EEL--------KHKY-------------------P-DQ---NGK---QG--
------------------------------------------------------------
-------------------------------------------TS------M--------
----------------------------------------KD--------ACL-------
----------V--------------------------------EGTS--TK---------
------------------------------------------------------------
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-----------------------------

------------------MKKIF------K------------------------------
---------------------------------------------------------GHS
PW----------------------GFLSFRH------------------A-ENQEPPRYL
TGYMPVKR-----IHK---------------AASVGDI----------------------
PQ---VQKMLEFG-DID--VN-VTDRK------------------KRTAL----------
----------HYAC--AHGQSEMVSLLLWYDCNIEA--RDREESTALIK-----------
-ATQRQHEICVKILL-ENGADSNAVDIH----QN--TSLHYTV-YNKDTTIAAKLLAFNA
DTEVKTKN-G---YTPLI------LAVLENKQEMVE-LLLQAAAN--------INAL---
-DNCKR-------SA-LIHAVR--TQSK--NMISL-------------------------
--LL-QQG-ANA--------SLVD------IYG-ATAQS---YA-VF---ETF---Q--V
LSQ---------------------------------------------------------
GPGPR-PELTTKEARHS-FD----------TKDGLVPCSPRFKEDNKRMEENTDAVDE--
------------------------------------------------------------
--------------------------------------LGSFAHRPSNSEPIEEEDEPSL
--------------ST--KPPV-------------------V--QSPVLTES--NLWA--
-----------GYP--A------------------DWPEPIKFSRQPAVYNPT-------
-------------EW--REDMESRSV----PLES------K-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------QQGAA---LPGKE-------------------------------------
------------------------------------------------------------
-----------------------------------ANI----QTQ---QQLQTRAFKEPG
ANDPDLPSRE-NAKDELV----------SL------------------------LAPLEE
KKPQMK----EFP----------------------------------------------V
TEAAKFQTDVKL---EREGVL-------EFEEKGLEICQDSN------------------
------------------------------------------------------------
--------LEA---------------------------------AESTESYSILRFAK--
PD------VSDPE-----------------------------------------------
----------------P-------------------------------------TARKDE
YKLDTKDEDRLERHLLAPKASQHQA-----------------------------------
------KQTSPPPVQLQER--SQ--GPEMDTA------------------------SDEE
DTSGLSKSAKGQILGGKLTLGENPE---------------------GKETVQCVINKPTQ
KG--DEIYED---------------VNAN-------------------------------
---VYLKEERPP-DVS-GKTHLTSDPTTLAY-NMFDCGDR--------------------
--DV---SAALVSVTLQTSPRQEEGGLGNAFPSPSSSQDVDYSGQSLTKF-PLM----R-
-----NKLDCENNASE--------LGESFHKRKEKSS-----------------------
------------------------------------------------------------
----------KNIESRKVKGKCPEV-R------MGEKQEGHEFKSQSQKT----------
--------------------------MKPKRTDWQLDIRHMLKSSDAN------------
--------R-LSNAKERSHVTEVK-------------------SWGD-SALASDM----Y
RKSKGTQDLFLKPLPCKGN----------FEAPART---------------LG---TASD
APPGGPTTRAFADEELRG----RL-SDSEFRILE-------------EEILAWEKVHLES
ESVSENL-LNKCEGIISD---------ATD----------QQGRYLD----------M-E
Q----A-TEVD--SE-------------GTSQLEQ---KNLDSSE-NTQP----------
---SNP-DLSKTC------------PQAQSAPADPT-------TLIQPLPEEE----SK-
------------------------QTH------PPSL--------RLKKMSEDLEIN---
-------TKDDKECAPG----------HPEVPSVKAHGRESLTGDRRGQNRESKQSCPEL
--QHTAADGLESICPVEDPLPGGCR---------SHFKVE---EVSRKQQSMDLEVSELS
PADEKDEPAR-SVPDLCIKD-AKGSEK--EAWSPREPVVTPEFEKSPPAG----------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------A---------D-LL------LLKDGHLLTK-
---------------------MDRVE-GRLTKREAKEKHK---TKSQVNE----------
-------------------------------------------------------M-EEA
SHGSE----------------------PRAP---AP--GWG--SDSPLKLWNT----THS
DERLIEL---KNSH-------------------CELLTRKPGKMGNM-------------
-----------REQTKVK---KTKTWSQHKEVA-WD-KL--CTLRFPLKQDEKQEN-AEL
TF-QQKKPQ----LQREKEQ------------------CGGSVEWTQ-H-SEIRTVIAEL
KALEKDLR-QFHN-----------------------------------------------
---------------LKESWET---TYYK------YLHMVVKLQFIEQELIGIKTEQKKC
RHLL-EN----------Q-KNLEEEVLHLK--------SWVRESEIQAR-----------
----DQNN-----------------------------------IENLRDTN--D----AA
MISQMDLRIKNMESQLATRGAQR--R----------------------------------
---------------------LLEEGCLDVSTA-M----------QKRVAWPSP------
------------------------------------------------------------
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-----------------------------

------------------MKRLSAAAVKGE------------------------------
--------------------------------------------------------TGPE
RPSP-------------------------------------------FSQLVYTNNDSYV
IHHGDLRK-----IHK---------------AASQGQA----------------------
WK---LERM-MKKTTMDLN---ITDAK------------------KRTAL----------
----------HWAC--ANGHAEVVTLLVDRKCQLDV--LDGENRTPLMK-----------
-ALQCQREACANILI-DSGADPNIVDVY----GN--TAVHYAV-YSENLSVVVKLLSCGA
DIEVKNKA-G---HTPLL------LAIRKRSEQIVE-FLLTKNAN--------ANAV---
-DKFKC------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------I--H-------------------------QQLLEYKQ--------
-----------K------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--ISKNSQ-------------------------------------------NS-------
------------------------------------------------------------
-------------------------------------------------NP--AEGTSEG
TPEEA-------------------------------------------------------
-------------AFLAER-------------------------------------T-PD
KAE---------------------------------------------------------
------------------------------------------------------------
-------------------CSV--ERTLDE------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-----------------------------

------------------MKKFFPFRGKRK------------------------------
--------------------------------------------------------TDDS
-------------------HSHSSEV-----PI----------SLAKTAPPSLSIGGGYH
LRDKHLKK-----LHK---------------AATIGNE----------------------
QK---LKDYLERKK-YN--VN-GRDKR------------------SRTPL----------
----------HLAC--ANGYTNIVSLLIENQCKINV--QDSENRTPLIK-----------
QAVECQQESCATVLL-LHGADPNLVDVY----SN--TALHYAV-CGQNISLANKLLQYKA
NLEAKNKD-G---HTPLL------LAVAENNENMVK-FLLKKGAD--------VNAS---
-DKNHR-------TA-IMIALI--VEPT--SSVKL-------------------------
--LL-QQD-TDL--------AHKD------IYG-FTAEE---YA-SF---NGF---TM--
--YHHITANNENKKKT--EQTAY-------------------------------------
------------------------------------------------------------
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-----------------------------

------------------MKKIFGFGKKKK------------------------------
--------------------------------------------------------WGPS
PNTS---------------------------------------------DTGSVLSVGYE
LKDKDLSK-----LHR---------------AASAGDV----------------------
GK---IKQL--IKK-QD--IN-QLDKE------------------NRTPL----------
----------HIAC--ANGQLDTVKLLLEHKSKLNL--CDNDNRSPLLK-----------
-AIQCQQESCATVLL-EHNADPNLVDIN----GN--AALHLAA-LIPSVSIAKQLLEHGA
NINAFNKE-G---CTPLI------LAVTENNEEMVE-FLLKEGAD--------INAC---
-DRGGS-------VA-QYIYKY--KDKL-----------------------------LFV
HHSA-S------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------YN---------------SDSH--------------------
------------------------------------------------------SQEES-
----------ESCISG--KSGD--------------V----D--SWPSSDED--------
-------NDDLDFCPQK-------------------TPKPSLTQLLKKKKHALGNSSIA-
--------------TTQPVGFTLHST--------SISE-----DESLHD----------S
RD----------E-----------------------------DVN---------------
------------------------------------------------------------
----------------------------HQHHPK--------------------------
----------------------------------PFSQTPAFPHPL--YFTPGSFTKPPQ
MASS---------------P---------------------------LSTITKACITPS-
--------------------------------KGGLKKKETL------------------
----------------------------------MDKIQD-SSNAD--DEN---------
DNSDFEESVE----SSPFK-----------------------------------------
-------IVELMSELG-LEEDDIESPWDSESA-SESSRKQVVSD--------------LP
LPAAKTQMQCISEE---S------NED----------------------------VSYRP
SFLRPSRSIPEHDLENT----------------------------SYAFYPTA-------
-------Y-------------------------------AHH------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------DQKM----------------
-------EKIQKNRTENAP----HQAEHQ-AKTVMQNVEDILA-SSDLELSWEEKYEKMW
--------------VDNEKKYVKTHF-----KNITAELNETSYSVTDG------------
S-----------------------------------------------------------
------------------------------------------------------------
------LPSN---------------------------------------NVPWDQDR---
--------------EKR------------------------------------------S
QGFIV------------------------------------------NFGT----SKKGN
FADSPGLECKEK------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------YVTVFQDQKCCNV-----------VN--
-------QPLKGK--------------------------------KNT------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------INGDPLEVFDDSTLSD-
-------------------TSQEDD--GRTPGKFTSKTNK---VIELLDNAG--------
------------------------------------------------------EL-EDF
SPSSDTATEEYGTP--TLPFRNAKMLIEQLG---VD--SQD--SVNLLKFQNI----IHE
YERTIQR---ENGR-------------------YKLLARKVKKMENE-------------
--KKDLQ----QIAEKNR---ELKSMLDHQKVE-SESDL--NSLRFTLKQEEEKRKNAEM
LY-GKSQEQ----LRRKEDQ------------------CCQEMEAKQLLELTIRNLELEM
RSMQNTVR-QVEEERNEVQRLLSHEHNARIAQEDIL-----NNIRRK--SEE---AE---
-KAQILPNSS--SGFSNEREKD---LILQ------NSNLQEEMNVLKLELDHVRSQNQQE
ESKYMDENENLKEKIADLRRDLKMNEETLT--------QTVIQYNSQLHAL-K------T
ENTMLCSK-----------------------------------LEHEKQGK---------
--DRLETELESIRSRLTSTLQEV--ERNQALKIEVE----RTLQRERDEWLRSQDKLNHE
LSTIRENNNNLS--------------------------Q-QLIRAETKSNS--LENELRQ
TN-TSLQDKVIL-SES--TQREL--THTCGRIKE-----LEHTLQL-EKDKI------CK
STVKQESLQEKLAQIQSENMLLRQQIEDVNNKG---IIKDKTVSDVQD----KFTEIIAK
IRADA-ERQVQIIEERNKDLIIKY-NETREQLYRLETEKVEREV-STLRQLQQELADA--
--LKKL------SMSEASLEVITRYRNDIEGEKQILQKEVEKFRI---------------
--------------------KKVQEYSSAAAGDENAIKELEGHVQKLEIENAKFEATAKQ
QAGQIDILQ----KELRET-----------------------------------------
------------------------------LSVESEKK-KVKKL---IEHKRSMEAR-FD
QEIKRNAELQRDISGLKKL-----LKTAK--------------KKIKE------LESVGT
--QQ-STQDGFKSTHFEKEIDIMKLKEKINELSFRLENESSNYKQLEAA-----------
-NRDL--QQQLSSMKMFHKSQEHLEKGKRQLEDEVANLKRQ---IEI-NKVDQSLIEKH-
KREIEERGRLEL-KQKLEEVNL---FLQSQAA-SQETLEQ-IRAA-NDASVRNQMEHRIQ
ELESDL-GKIKNAQQENMLQRESTQTELERFK----ELYNEELKNRNSLA-LKLERSNER
LADANAKLLNERQR---TKSLIASSIMNGSLATSPVVDASSFGNFSN-----SGFRLGGS
FLS-STANGMN-TNR-VENYLTKMQQELEKNITKELDQVANAE-----LES-----G---
-------------------SSARVSPVGSI---------AGSLRNLNVDQDPVSRATQQY
LEVLKKN--YKI------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------MRKLFSFGRRLG------------------------------
--------------------------------------------------------QALL
SS----------------------------------------------MD-EEYAGRGYH
TQDWELRK-----IHR---------------AAIKGDA----------------------
AE---VERCLTRRF-WD--VD-ARDRK------------------DKTVL----------
----------HLAC--AHGRVEVVTVLLSSSCQIDI--CDRLNRTPLMK-----------
-AVHCQEEACAIILL-ERGANPNIKDIY----SN--TALHYAV-YNKGTSLAEKLLSHRA
NIEALNEE-G---NTPLL------LVGICRRQQMVE-FLLKNQAN--------VHAV---
-DNFRR-------TA-LMHAVQ--HNSS--SIVSL-------------------------
--LL-QQN-INI--------FYQD------MFG-QTAKD---YA-VC---CDL---RR--
--YMLILR----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------DR-------L-------
-----------------------------IL----------N------------------
------------------------------------------------------------
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-----------------------------

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------------------------------------------------------------
---------------------ACAHG--H------V----EVVTL-LLSR----------
--ICQI------------------------------------------------------
-----------------------------------------------------DICDRLN
R-----------------------------------------------------------
-----------------T--------PLMK------------------------------
----------EEACAIILLE-HGANPNI-----------KDIY-----------------
------------------------------------------------------------
--------GNTALHYAVYN K--GTS--LAEKL TA--------------------------
--------------------------LMLAVQHNSPSILSLLLQQNINIFSQDTFGQTAE
DYAVCCD--LRSIQQQILEHKNKILK-NRLRNDNQET-----------------------
------------------------------------------------------------
--AAVK-------P--AN-----LK-KR------KE--G---------------------
---------------------------------------AKG------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------ESLERKKD---VMYG------NDILKRDIAMLKQELYTIKNDSLRK
EKEYIQEIKSITEMNANFEKSVRLNDEMIA--------KTTAQYSQQLNEL-KA------
ENTRLTSK-----------------------------------LEKEKHKK---------
--ERLEAEVESLHSNLATAINEY--NEIL-ERKDLE----LALCRADDV--SGHEKMDSN
ISQLTDKNELLT--------------------------K-QLSKARVKFST--LKGKLHE
TR-DALREKTLA-LES--VQMDL--KQAQYRLKE-----MKQMHPN-EEAKE------SQ
SFGKQNSLEERIHQQELENLLLEQKLKDAYEEG----NNKEIVINIQE----DC------
--LEN-GKEDLLTEEKNMELMNEY-NYLKEKLFQYEKEEAEG EV--IVRRLQEELADH--
--LNKF------SMSESPLEGTSHCHINLDE-TRASKKKLFQVGSQ-KEKERERKERKE-
-GQS--------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------ILVNIQR
KRKKKRKEKKEKGQSILK-------------------CLEMTINMLNV------FGNED-
---F-SCHGDLNIDQLKMDTLFKKLKQKFDELTAEKEAVSSKYVNLAKD-----------
-NQVL--QQEFLSMRKIQEKCEKLEEDKKILEEEVLTLKTH---MEN-NMVELGKGQEY-
KLELDERILQAI--EKLEKISL-----QEQAK-YEKQLEQ-LNK--DNMASL NKKELTLK
DVECKF-SNMKTAYEEV-------TTELEEYK----EAFAVALKANNSMS-KNLTKLNKK
IVVISTKLLMEKER---MKYFLS------TVPIRPDPELPCIENLNH-IGFNRKYIPKTP
IRI-PTSNPQTSNNY--ENSLT------------ELLL----------------------
---------------------CWALAPIYFLL----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

---------------------MLGLGKKRR------------------------------
--------------------------------------------------------EPPE
PLPL--------------GH-AWAG------------------------SRLGLAGGLYK
VRSKELPR-----LHR---------------AAAEGDL----------------------
VE---VRHLL-RRH-HD--PD-ERDKS------------------DRTPL----------
----------HFAC--ANGCIDVVTFLVSNQCQLDL--YDSDTRTPLMK-----------
-AVQCQQDLCAIYLL-EQGADPDLVDAY----SN--TALHFAA-FNSSISIAKHLLEYNA
NVEAQNKD-G---NTPLI------VAVTENNREMVE-FLLKQGAS--------VHAT---
-DNSGR-------TP-LLIATS--NKKR--DLTNI-------------------------
--LL-FHG-SDV--------SHKD------ESG-WSARD---YA-LL---SDD---PI--
--LLQYIADYSRQRDKE-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-----------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TAL----------
----------HLAC--ASGRQEVVTLLAERKCELYI--RDGRGKTALIM-----------
-AVQCQEEKCANILL-EHGADPKAADVN----GN--TALHYAA-HHGMISIAEKLLSLSV
NIDVKSKV-L--------------------------------------------------
------------------------------------------------------------
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-----------------------------

------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------GYD
VHNADLKS-----LHR---------------AVYEGDI----------------------
SI---IHDLIELK-RNK--LN-SYDKK------------------NRSPL----------
----------HLAC--VKGYARVATMLIDKRCDLNI--RDAEQRTPLIK-----------
-AVQCEKLECVTLLL-ERGADPNIVDIH----GN--CALHYAA-HSGNVEIATKLLEHGA
TTEIMNKG-GHKDTTPLF------LALKETHSDVAE-LLIKNKAN--------IHLV---
-DGCKR-------TA-LMPAVL--CNSD------L-------------------------
--LL-EQN-INV--------FAED------LFG-RTTDN---FL-AP---DSE---S---
--C----QKFPNNVAGKDRSS---------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-----------------------------

------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------GYR
IRGKDLRK-----LHK---------------AASKGDV----------------------
AR---VQHLLLLK-KSS--VN-DRDRK------------------NRTAL----------
----------HLAC--ADGHSEVVTLLLERKCVINV--PDDDNMTPLMK-----------
-AVQS-----ARILL-DHGAGANVIDDN----GN--TALHYAA-YCENAGIA------NT
NVEVRNKD-G---FTPLL------LAIYENGEEIAE-FLIK--AN--------IHVV---
-DKIKR-------MA-LMLAAQ--YRSR---IVRL-------------------------
--LL-EKG-IDA--------SCLN------TYG-WPAEK---LA-LV---TFN---L---
-ANRQLILDYEDEHRYKMLEKHL-------------------------------------
------------------------------------------------------------
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-----------------------------

-----------------------MDD----------------------------------
--------------------------------------------------------KEPK
RWPT--------------LRD----R---LC-------------------SDGFLFPQYP
IKPYHLKG-----IHR---------------AVFYRDL----------------------
EE---LKF-VLLT-RYD--IN-KRDRK------------------ERTAL----------
----------HLAC--ATGQPEMVHLLVSRRCELNL--CDREDRTPLIK-----------
-AVQLRQEACATLLL-QNGADPNITDVF----GR--TALHYAV-YNEDTSMIEKLLSYGA
NIEECSED-E---YPPLF------LAVSQRKVKMVE-FLLKKKAN--------INAV---
-DYLGR-------SA-LIHAVT--LGEK--DIVIL-------------------------
--LL-QHN-IDV--------FSRD------VYG-KLAED---YA-SE---AKN---RV--
--IFELIYEYERKK-HEELSINS-----NPVSSQ----------------KQPALKATSG
KEDSISNIATEIKDGQKSGTVSSQKQPALKGTSDKNDSVSNTATEIKDEQKS---GTVSS
Q---KQPALKDTSDKNDSV----SNTATEIKDEQKSGTV---------------------
--------------------------------LPAVEQCLNRSLYRP------DAVAQP-
--------VTEDEFAL--ESEIISKLYIPKRKIISPRSIEDV--LPPVEEAVDRCLYLLD
RFAQAVTKDKFALESEN------------------IS-EPYFT----NRRTIS-------
------Q---QSAEKL-DAACGIDKTENGTLFEDQNV---DKEGK------------A--
------------------------------------------------------------
------------------------------------------------------------
-------------------------------LPA--------------------------
---------------------------T--------------GQKA--NVSPEQPPLF--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------THTVKD
SDHISTRFLGSMDSLTSSEESSERPPLSTLTL-K--------------------------
----------------------------------------EADPSSKAAMRRKDS-----
------------------------------------PPPGKVSSQKQPAEKAT----SDD
-KDSVSNI-----------------------------ATEIKEGPISGTVSSQK------
------QPAEKATSDEKDSVSNIATEI---------------------------------
-----------KEGQQSGTVS--------PQKQSAWKVIFKKKVSLL--NI------ATR
ITGGG---KS--GTVSSQKQPPSKATSDKTD----------SALNIATEIKDG-------
------LQCGTVSSQKQPALKAT---TDEEDSVSNIATE-----------------IKDG
EKSGTVSSQKQPALK------------ATTDE---EDSVSIIA----------TEIKDGE
KSGTVSSRKKPALKATSDEKDSFSNIT------REKKDGEISRTV---------------
------------------------------------------------------------
----------------------------------------TSEKP----------AGLKA
------TSDEEDSVLN--------IARGKEDGEKTRRVS----------S---RKKP---
-A---------L-------KATSDEKD-SF-SNI-TREKKDGETS-----R---TVSSQK
PPALKATS---------------DEEDSVLNIAREKKDGEKSRTVSSEKPSGLKATS---
-----------------DEKDS-VLNIARGKKHGEKTRR---------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------VSSHKQPA-----------LKATSDKENSVPNMATET-KD------------
EQISGTVSSQKQPALKATSDKKDSVSNIPT-------E--I----------KDGQQSGTV
-----------------------------------SSQKQ--LAWKATSVKKDSVSNIAT
------------------------EIKDGQIRGTVSSQRQPALKATGDEK----DSVSNI
AREIKDGEKSGTVSPQK---------Q-------SAQKVIFKKKVSLLNIATRITGGWK-
-------------------------------SGTEYPENLPTLKATIEN-----------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------KN-SVL-NTATKMKDVQTSTP-
EQDLEMA------SEGEQKRLEEYEN-NQPQVKNQIH---------SRDD----------
-------------------------------------------------------L-DDI
IQSSQTVSEDGD--SLCCNCKNVILLIDQHE---MK--CKD--CVHLLKIKKT----FCL
CKRLTEL---KDNH-------------------CEQLRVKIRKLKNK-------------
--ASVLQ----KRLSEKE---EIKSQLKHETLE-LEKEL--CSLRFAIQQEKKKRRNVEE
LH-QKVREK----LRITEEQ------------------YRIEADVTKPIKPALKSAEVEL
KTGGNNS-----------------------------------------------------
---------NQ-VSETDEK-ED---LLHE------NRLMQDEIARLRLEKDTIKNQNL--
EKKYLKDFEIVKRKHEDLQKALKRNEETLA--------ETIACYSGQLAAL-T------D
ENTTLRSK-----------------------------------LEKQRESG---------
--QRLETEMQSYRCRLNAALCDH--DQSHSSKRDQE----LAFQGTVDKCCHLQENLNSH
-------VLILS--------------------------L-QLSKAESKFRV--LETELHY
TG-EALKEKALV-FEH--VQSEL--KQKQSQMKD-----IEKMYKS-GYNTM------EK
CIEKQ----ERFCQLKKQNMLLQQQLDDARNKA---DNQEKAILNIQA----RCDARVEN
LQAEC-RKHRLLLEEDNKMLVNEL-NHSKEKKCQYEKEKAEREV--AVRQLQQKQDDV--
--LNKR------SATKALLDASSRHCIYLENGMQDSRKKLDQMRSQ-FQEIQDQLTATIR
C-----------------------------------TKEMEGDAQKLEVENVMMRKIIKK
QDEQIERFE----KILQHS-----------------------------------------
------------------------------SLM-------------------LQVFE-S-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TAL----------
----------HLAC--TRGQSSVVALLIQWKCDLNA--RDEEGKTALIK-----------
-AVQCQKELCVTVLL-EHGADPNLVDDC----HN--TALHYAI-LAEDTSIAAKLLCYKA
DIEAMNKY-K---YTPLL------LTIRENREEMAK-FLIENGAN--------VHAV---
-DKLQS-------LY-QLIVDY--RAGK--IPDTSPQNSDLGGTSLKITLAER----TGA
K-----------------------------------------------------------
------------------------------------------------------------
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-----------------------------

------------------MKKLFHFWRRKN------------------------------
--------------------------------------------------------ESSS
-----------------------------------------------PPSSDLPMGLGYH
LQDKDLKK-----VHK---------------AALAGDL----------------------
EK---LTKCLQVKK-QD--VN-VRDKE------------------YRTPL----------
----------HFAC--ANGHVNIVYFLIEKQCEINV--LDSENRSPLIK-----------
-AVQCQKEDCANILL-NCGADPNLVDFL----NN--SALHYAV-CGQSVSLVEKLLQHEA
DLEAKNKD-G---YTPLL------LAVSKNNAEMAK-FLLMKGAD--------VNAT---
-DKNQR-------TA-LMIAIS--GEPT--SLVNI-------------------------
--LF-QQD-VDL--------SRQD------IYG-FTAEI---NM-KVQMIRLH---YR--
--YHQLTSNNGTKNKV--K-----------------------------------------
------------------------------------------------------------
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-----------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------MRDRA------------------HRTPL----------
----------HLAC--ANGYPHIVSALLEKRCNIHA--QDGENRSPLMM-----------
-AVKCQKEDCAVLLL-KHGADPNLTDGH----GN--TALHYAV-CGTSVSLVEKLLKHKA
NLEAQNR-----------------------------------------------------
------------------------------------------------------------
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-----------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------I
TGYCAVGQ-----LHR---------------AASVGAV----------------------
AT---VERFLTFRL-NG--VN-DTDKR------------------NRTAL----------
----------HYAC--AHGHLGVVTLLIERNCNVNA--RDDDKCTPLIK-----------
-ASQHQREDCVAVLL-QHGADPNAVDAL----GN--TALHYAV-HSENASIASQLLEHSA
NIEARTK-----------------------------------------------------
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-----------------------------

MEEEINY-------DSQTMN--I------P------------------------------
---------------------------------------------------------RRR
RWYT--------------HL--WRSCLGLRC--------------MH--PQKKKKYPLYL
IGYDPIGP-----LQR---------------AASVGDL----------------------
DT---TEKLIHSS-QHH--VD-ESDRR------------------KRTSL----------
----------HYAC--AHNHPDVVTLLLENNSSINI--RDDEGCTPLIK-----------
-ATQRDNVDCASVLL-THNADPNLIDSS----GN--TAFHHAI-SRGNIRIVKMLLEHNV
DIEAKTEY-G---LTPLQ------LATFEQKPEMVE-FLAAKCAK--------SSVT---
-PSWSP-------SP-TVSPCP--SSTS--PLSSL-------------------------
--GL-PVC-PNP--------GTSS------LSE-DRKSS---SA------RRI-------
-KL---------------------------------------------------------
STGSSAQRTEVKHVRFN-EEVLYF------KEERPLSCEARPPRQLKSILKNT------V
--------------------------------------QYNTVNEKITRRTSLW------
------CSKAEDVR------------------YTSCIKVKCFSVKSSFL-----------
------------------------------------------------------------
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-----------------------------

MVA-----EAGSMPAASSVKKPFGLRSKMGKWCRHCFPWCRGSGKSNVGTSGDHDDSAMK
TLRSKMGKWCRHCFPWCRGSSKSNVGTSGDHDDSAMK-----------------------
--------------TLRSKMGKW-CCHCFPCCRGSGKSKVGPWGDYDD---SAFMEPRYH
VRREDLDK-----LHR---------------AAWWGKV----------------------
PR---KDLIVMLKD-TD--MN-KKDKQK------------------RTAL----------
----------HLAS--ANGNSEVVKLLLDRRCQLNI--LDNKKRTALTK-----------
-AVQCREDECALMLL-EHGTDPNIPDEY----GN--TALHYAI-YNEDKLMAKALLLYGA
DIESKNKH-G---LTPLL------LGVHEQKQQVVK-FLIKKKAN--------LNAL---
-DRYGR-------TA-LILAVC--CGS-A-SIVSL-------------------------
--LL-EQN-IDV--------SSQD------LSG-QTARE---YA-VS---SHH---NV--
--ICQLLSDYKEKQMLKVSSEN--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------SNPEQ-----------
---------DLKLTSEE------------------ESQ------------RLK-------
--------------------------------GSENS-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------QPE--------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------EMSQEPEINK-----------
---GGDRKVE--------------------------------------------------
---------EEM------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
-----------------------------------K--KHG--STHMG------------
-------------F-------------------PENLPNGATADNGD-------------
--DGLIP----PRKSRTP---ESQ-----QFPD-TENEQ--Y-HS---------------
------------------------------------------------------------
------------DEQNDTQKQLSEEQNTGILQDEIL-----IH---E--EKQIEVAE---
-N-EF-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------MKRIFGFGRRKS------------------------------
--------------------------------------------------------DQSL
SSG-------------------------------------------------SPGGSGYR
LQDRDLGK-----IHR---------------AASRGNV----------------------
AK---VQQILLLGK-NG--VN-DKDKK------------------NRTAL----------
----------HLAC--ANGHAEVVTLLVERKCQLNV--YDSEHRTALMK-----------
-AIQWKEEECATILL-QHGADPDITDAS----GN--TALHYAV-CAEHIPIAAKLLSYNA
NIEARNED-G---FTPLL------LAVDENKQQMVE-FLVKKEAN--------IHAV---
-DKTKS-------SR-KMISEY--KKKK--LPVSSSQNNNP-EETANITCLAE----GTA
STNE-EEH-SEEDSLSRLSIKPGI------DDS-WPTPDEKDFD-FD---HKE---GI--
--TKPAI-----------TEKEA-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------G--------------
----------VG--IT--E-------------------------SAPREQT---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----NSG-------------------------------------------NI-------
------------------------------------------------------------
-------------------------------------------------C----------
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-----------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
IRDKDLRK-----IHK---------------AAIVGNV----------------------
AK---VENDLSKND-FK--ST-NRNVA------------------QRTAL----------
----------HLAC--ANGHSAVVTLLLERKCLLNL--CDNENRTALMK-----------
-ALECQEEECATLLL-EHGADPNVMDIS----GN--TTLLYAV-FCQNISLAAKLLSCDA
NIEARNKN-N---LTPLL------LAIIEKREQMVE-FLVKKGAN--------THAV---
-GNLKR-------TA-LMLAVS--YGLA--NVVGL-------------------------
--LL-QQG-VDI--------FSQD------VFG-WTAED---YA-SI---S---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------G--------------
----------F-------------------------------------------------
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------------------------------------------------------------
-----------------------------

------------------MNKLFSFWKRKN------------------------------
--------------------------------------------------------ETR-
-------------------------------------------------------SQGYN
LREKDLKK-----LHR---------------AASVGDL----------------------
KK---LKEYLQLKK-YD--VN-MQDKK------------------SRTPL----------
----------HLAC--ANGHRDVVLFLIGQQCKINI--RDSENKSPLIK-----------
-AAQCQNEDCATILL-NCGADPDLRDIH----YN--TALHYAV-CGQSVSLVERLLDYEA
DLEMKNKD-G---YTPLL------VAVISNNPKMVK-FLLEKGAD--------VNAS---
-DNYQR-------TA-LILAVS--GEPT--RLVNL-------------------------
--LL-QQG---------------------------LRNM---LI-SM---VLL---YI--
--HNSLQVMERRNMLN--RHLIL-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------G--------------
----------TT--CD--------------------------------------------
------------------------------------------------------------
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-----------------------------

------------------MKKIF---SKKG------------------------------
--------------------------------------------------------ESPL
GSFA----------------RRRRSSAGGGG----------------EPGEGAYSQPGYH
VRDRDLGK-----IHK---------------AASAGNV----------------------
AK---VQQILLLRK-NG--LN-DRDKM------------------NRTAL----------
----------HLAC--ANGHPEVVTLLVDRKCQLNV--CDNENRTALMK-----------
-AVQCQEEECATILL-EHGADPNLADVH----GN--TALHYAV-YNEDIPVATKLLLYDA
NIEAKNKD-D---LTPLL------VAVNGKKQQMVE-FLIKKKAN--------VNAV---
-DKLES-------SH-QLISEY--KEER--IPKNSSQNSNSVDESSED------------
-------S-LSR--------NTEK------R-----------------------------
-----NLQ----RHDLSSL-QPP-------------------------------------
LPG---------------------------------------------------------
---------------------------------------------------FT-------
-------Q----------------------------------------------------
FSCLCLPSSCDHRLSG--KPGV--------------D----D--SWPTSDD---------
--------DDLNFHTKN-------------------VPKPSLAKLMTASQQSRK---NLE
ATYGIVRT------------------GSRTLFEDRDSDSQ--------------------
---------------------D-------------------EVVV---------------
------------------------------------------------------------
-----------------------------ESLPT--------------------------
----------------------------------TSVKAQGFSHPT--CQSPDPLP-KPS
HKS---------------------------------------------------------
----------------------------------------LANP----------------
-----------------------------------GLIKEGPTKPAIGKKE---------
---NGIDIIE----SAPLE--------------QTNNDN-------------LTYVDEVH
KNN----RSDMMSALGLGQEEDIESPWDSESI-SENFPQKYVD---------------PL
AGAAYRKEKNIGNE---Q------AE----------------------------------
-----------------------------------------ESPERYLHLKPT----IEM
-KDSVPNK-----------------------------AGGTK------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------DV------------------
---------------------------------------------QTSK-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------AA
EHDLEVASEEEQER-EE-------------SENHQPQVE--------EERKKHR------
---------------------------NSEMEVS---ANIHDGKSEE-------------
----------------------------T----DQHIPRKENKEY---------------
---------ASSGPALQMKE-VKR--------TAKESVNSPVFEKAGLL-----------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------TGGLLQV---------
--------------------------------------------KNQIQSMD--------
------------------------------------------------------DV-DDL
TQSSETASEDCELP--RSSYKNFMLLIEQLG---ME--CQD--SVSLLKIQDA----ALS
CERLLEL---KKNH-------------------CELLTVKIKKMEDK-------------
--VSVLQ----KELSETK---EIKSQLEHQKVE-WEREL--CSLRFSLNQEEEKRRNADM
LY-EKIREQ----LRRKEEQ------------------YRKEVEVKQQLQLSLQTLEMEL
RTVKSNLN-QVVQERNDTQRQLSREQNARMLQDGIL-----TNHLSK--QKEIEMTQ---
-RKMNSENSH-----SREEEKD---LLHK------NSMLQEEIAMLRLEIDTIKNQNQEK
EKKCFEDLEIVKEKNEDLQKTIKQNEETLT--------QTISQYNGRLSVL-T------A
ENAMLNSK-----------------------------------LESEKQSM---------
--ERLEAEVESYRSRLAAAIHDR--DQSETSKRDLE----LAFQRARDEWSRLQDKMNFD
ASHLKDNNEILS--------------------------Q-QLFKTESKLNS--LEIELHH
TR-DALREKTLG-LER--VQKDL--SQTQCQMKE-----MEQKYQN-EQVKV------NK
YIGKQESVEERLSQLQSENMLLRQQLDDAHNKA---DNKEKTVINIQD----QFHAIVQK
LQAES-EKQSLLLEERNKELISEC-NHLKERQYQYENEKAER E-----------------
-----------------------------------------------LQEAQDRHTEAVR
C-----------------------------------AEKMQDHKQKLEKDNAKLKVTIKK
QMDKIEELQ----KNLLNA-----------------------------------------
------------------------------NLSEDEKE-QLKKL---MELKQSLECN-LD
QEMKKNVELEREITGFKNL-----LKMTR--------------KKLNE------YENG--
--EL-SFHGDLKSSQFEMDIQINKLKHKIDDLTAELETAGSKCLHLDTK-----------
-NQVL--QQELLSMKTIQKKCEKLQKNKKKLEQEVINLRSH---IER-NMVELGQVKQY-
KQEIEERARQEI-VEKLKEVNL---FLQAQAA-SQENLEQ-LREN-NFASM KSQMELRIK
DLESEL-SKIKTSQE------DFNKTELEKYK----QLYLDELKVRKSLS-NKLNKTNER
LAEVSTKLLVEKQQ---SRSLFT------TLTTRPVMEPPCVGNLNNSLDHNRKLIPREN
LVI-SSSNPRTSNNS-VENYLSKMQQELEKNITRELEEA-AAE-----LES-----G---
--------------------S-IASPLGST---------DES----NLNQDLVWKASREY
VQVLKKN--YMI------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

---------------------MVGF-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------LLRNQ-AN--IH-AVDKM------------------KRTAL----------
----------ILAV--NFASSSVVRLLLE-------------------------------
-----------------QGVDISPQDRY----GR--NAEDYAV-IK-G------------
-------H-------------------HMNHHMILE-YKREMGPK--------TPAQ----DSN----------L-DLTAE----ESP----RQISRETD-----------------------------STQ--------VHES------SE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EDSLSSFSS--KPHV------------------DD--TWPTSDTVT----------------DFDLEEGDKKPGMEPKETRTDVMESIPQEPPNLDHFTSVDGAHRENRSGVLSASGLEEE-------------DIASSLDTECASESLS-------QK--TVYHISRAADERGKKRGNKEVEASPEKYPHSKPT-----VGVKDAVPNKTVGTKDLQASRSDSVPLCKIQGAVLSSERSLKVKNSQCEVLEGKIKNMESKISGLQAELSETKEVQSQLEQQKVEQQQELCSLRLYLKHEEEQRKKADMLSEEIREQLRRKEEQCSKETELK--QQLELTLEVLQGELKTVRNKANQLQEAQDRYM---EAVKCTEKMQDQMQKLQKENAELKDTNKMQ--AGTI-------EELQR----------------------------------------------------------------------------------------------------------------------------------------------------NPPGPSSEGDKKPGTEPKE------------TRTDVME----SIPQEPP--------------NLDHFT-------------SVDGAHREN----RSGVLSASGLEE-EDIASSLDTECA-SESLSQKYVD--H-------------LSGTS--------------------------------------------------GQ-----------------------------------------------------------------------------------------------------------RG-----KNRVNGEV--ED---VPYI------PS---CMSGSSNFKRAQ------Q--E----------------------------------------------------------------------------------------------------------------------------------------------DPRHGGLAV---------------AHMAS-------------------------------PEKY----------------------------------------------------------------------------------------------------------------------PHSKPTVGVK------DAVPNKTV--------------------------------------GTK-----------------------------------------------------------------------------------------------------------------DLQA-------------SRS----DLPQSSDHKSPFDLPLAYSKEMNAMIQRRNHDISAVKKTSNQTKPVQDWSKKLWYASNFHAKKRKSIK-PK-L--ET-WTCPPNSNRTSKIYLKEEL-----------------------------QQSMQRCKNKAEKEKKQH---RSSVMAVSE-----------NNHGSD-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDSGL-MQQG------------ERGK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TNHQWFPTVENGDS----------------------DS--SSSGMHMKE-VWKNERE--KWSSKGPVIPPIF-----------EK--------------------------ADSLPIDLL----------------------------------------------------------------HV--NDDR----S----------------------------------------------------------------------------------------LSERDQDD---GRPIKRTPNEENK---VKEQINSVD--------------------------------------------------------------DF-DDLTQLPETASKDRELL--SSKSMNAMLLIEQLG---TE--CK--DSVSVLKKQDS----VLSDDSLLEI---KKSH-------------------YELLTGKIKKMKSK---------------IIGLR----KELSEAK---EVKSQLEHQILE-WQQEF--YSLRCTLKQEEEKRRNVYKLY-EKTRKE----LRRRKER------------------YDKEAEMKQQLELTVQALDMELRAVRNNLN-QGD--------------------------------------------------------------ESHEKAKE---LLPK------NHMSQNEIAMLKHEIEAVENHNQEMEKKYFMDMKIVKKKYAEVRKTIKLNEETLT--------KIILER----NEL-TA------ENTMLKSE-----------------------------------LENERQNK-----------ERLERQVESYRSRLAA-THDQ--VQSQTSKRDLE----LAFQRGRDKCLPLQDEINLDVSNLKD-NEVHS--------------------------Q-QLSKSEGKSNG--LETELHHGR-DALREKSLV-FETVPVQRDL--SQAQCQ-KE-----IEHMPPS-EQGKV------KKYMDKQESSKGRLSQLESENLLLRQQLDDLQNKK---ESQQKRVINIQD----QFQNTVKSLQAKS-EKQYLMLEERNKELTKEY-SHLKESINQYENEAMEREV--VVEQLQQELADS----LKKQ------SLSEASLELMLRDCAKLEDERQDLKKKVHQMTSK-A--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RTAL--------------------ILAV--NFASSSVVRLLLE------------------------------------------------QGVDISPQDRY----GR--NAEDYAV-IK-G-------------------H-------------------HMNHHMILE-YKREMGPK--------TPAQ----DSN----------L-DLTAE----ESP----RQISRETD-----------------------------STQ--------VHES------SE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EDSLSSFSS--KPHV------------------DD--TWPTSDTVT----------------DFDLEEGDKKPGMEPKETRTDVMESIPQEPPNLDHFTSVDGAHRENRSGVLSASGLEEE-------------DIASSLDTECASESLS-------QK--TVYHISRAADERGKKRGNKEVEASPEKYPHSKPT-----VGVKDAVPNKTVGTKDLQASRSDSVPLCKIQGAVLSSERSLKVKNSQCEVLEGKIKNMESKISGLQAELSETKEVQSQLEQQKVEQQQELCSLRLYLKHEEEQRKKADMLSEEIREQLRRKEEQCSKETELK--QQLELTLEVLQGELKTVRNKANQLQEAQDRYM---EAVKCTEKMQDQMQKLQKENAELKDTNKMQ--AGTI-------EELQR----------------------------------------------------------------------------------------------------------------------------------------------------NPPGPSSEGDKKPGTEPKE------------TRTDVME----SIPQEPP--------------NLDHFT-------------SVDGAHREN----RSGVLSASGLEE-EDIASSLDTECA-SESLSQKYVD--H-------------LSGTS--------------------------------------------------GQ-----------------------------------------------------------------------------------------------------------RG-----KNRVNGEV--ED---VPYI------PS---CMSGSSNFKRAQ------Q--E----------------------------------------------------------------------------------------------------------------------------------------------DPRHGGLAV---------------AHMAS-------------------------------PEKY----------------------------------------------------------------------------------------------------------------------PHSKPTVGVK------DAVPNKTV--------------------------------------GTK-----------------------------------------------------------------------------------------------------------------DLQA-------------SRS----DLPQSSDHKSPFDLPLAYSKEMNAMIQRRNHDISAVKKTSNQTKPVQDWSKKLWYASNFHAKKRKSIK-PK-L--ET-WTCPPNSNRTSKIYLKEEL-----------------------------QQSMQRCKNKAEKEKKQH---RSSVMAVSE-----------NNHGSD-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDSGL-MQQG------------ERGK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TNHQWFPTVENGDS----------------------DS--SSSGMHMKE-VWKNERE--KWSSKGPVIPPIF-----------EK--------------------------ADSLPIDLL----------------------------------------------------------------HV--NDDR----S----------------------------------------------------------------------------------------LSERDQDD---GRPIKRTPNEENK---VKEQINSVD--------------------------------------------------------------DF-DDLTQLPETASKDRELL--SSKSMNAMLLIEQLG---TE--CK--DSVSVLKKQDS----VLSDDSLLEI---KKSH-------------------YELLTGKIKKMKSK---------------IIGLR----KELSEAK---EVKSQLEHQILE-WQQEF--YSLRCTLKQEEEKRRNVYKLY-EKTRKE----LRRRKER------------------YDKEAEMKQQLELTVQALDMELRAVRNNLN-QGD--------------------------------------------------------------ESHEKAKE---LLPK------NHMSQNEIAMLKHEIEAVENHNQEMEKKYFMDMKIVKKKYAEVRKTIKLNEETLT--------KIILER----NEL-TA------ENTMLKSE-----------------------------------LENERQNK-----------ERLERQVESYRSRLAA-THDQ--VQSQTSKRDLE----LAFQRGRDKCLPLQDEINLDVSNLKD-NEVHS--------------------------Q-QLSKSEGKSNG--LETELHHGR-DALREKSLV-FETVPVQRDL--SQAQCQ-KE-----IEHMPPS-EQGKV------KKYMDKQESSKGRLSQLESENLLLRQQLDDLQNKK---ESQQKRVINIQD----QFQNTVKSLQAKS-EKQYLMLEERNKELTKEY-SHLKESINQYENEAMEREV--VVEQLQQELADS----LKKQ------SLSEASLELMLRDCAKLEDERQDLKKKVHQMTSK-A--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RTAL--------------------ILAV--NFASSSVVRLLLE------------------------------------------------QGVDISPQDRY----GR--NAEDYAV-IK-G-------------------H-------------------HMNHHMILE-YKREMGPK--------TPAQ---
-DSN----------L-DLTAE----ESP----RQISRETD--------------------
---------STQ--------VHES------SE----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------EDSLSSFSS--KPHV------------------DD--TWPTSDTVT-------
---------DFDLEEGDKKPGMEPKETRTDVMESIPQEPPNLDHFTSVDGAHRENRSGVL
SASGLEEE-------------DIASSLDTECASESLS-------QK--TVYHISRAADER
GKKRGNKEVEASPEKYPHSKPT-----VGVKDAVPNKTVGTKDLQASRSDSVPLCKIQGA
VLSSERSLKVKNSQCEVLEGKIKNMESKISGLQAELSETKEVQSQLEQQKVEQQQELCSL
RLYLKHEEEQRKKADMLSEEIREQLRRKEEQCSKETELK--QQLELTLEVLQGELKTVRN
KANQLQEAQDRYM---EAVKCTEKMQDQMQKLQKENAELKDTNKMQ--AGTI-------E
ELQR--------------------------------------------------------
------------------------------------------------------------
--------------------------------NPPGPSSEGDKKPGTEPKE---------
---TRTDVME----SIPQEPP--------------NLDHFT-------------SVDGAH
REN----RSGVLSASGLEE-EDIASSLDTECA-SESLSQKYVD--H-------------L
SGTS--------------------------------------------------GQ----
------------------------------------------------------------
-------------------------------------------RG-----KNRVNGEV--
ED---VPYI------PS---CMSGSSNFKRAQ------Q--E------------------
------------------------------------------------------------
------------------------------------------------------------
----DPRHGGLAV---------------AHMAS---------------------------
----PEKY----------------------------------------------------
------------------------------------------------------------
------PHSKPTVGVK------DAVPNKTV------------------------------
--------GTK-------------------------------------------------
------------------------------------------------------------
----DLQA-------------SRS----DLPQSSDHKSPFDLPLAYSKEMNAMIQRRNHD
ISAVKKTSNQTKPVQDWSKKLWYASNFHAKKRKSIK-PK-L--ET-WTCPPNSNRTSKIY
LKEEL-----------------------------QQSMQRCKNKAEKEKKQH---RSSVM
AVSE-----------NNHGSD---------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------DDSGL-MQQG----------
--ERGK------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------TNHQWFPTVENGDS---------------
-------DS--SSSGMHMKE-VWKNERE--KWSSKGPVIPPIF-----------EK----
----------------------ADSLPIDLL-----------------------------
-----------------------------------HV--NDDR----S------------
------------------------------------------------------------
----------------LSERDQDD---GRPIKRTPNEENK---VKEQINSVD--------
------------------------------------------------------DF-DDL
TQLPETASKDRELL--SSKSMNAMLLIEQLG---TE--CK--DSVSVLKKQDS----VLS
DDSLLEI---KKSH-------------------YELLTGKIKKMKSK-------------
--IIGLR----KELSEAK---EVKSQLEHQILE-WQQEF--YSLRCTLKQEEEKRRNVYK
LY-EKTRKE----LRRRKER------------------YDKEAEMKQQLELTVQALDMEL
RAVRNNLN-QGD------------------------------------------------
--------------ESHEKAKE---LLPK------NHMSQNEIAMLKHEIEAVENHNQEM
EKKYFMDMKIVKKKYAEVRKTIKLNEETLT--------KIILER----NEL-TA------
ENTMLKSE-----------------------------------LENERQNK---------
--ERLERQVESYRSRLAA-THDQ--VQSQTSKRDLE----LAFQRGRDKCLPLQDEINLD
VSNLKD-NEVHS--------------------------Q-QLSKSEGKSNG--LETELHH
GR-DALREKSLV-FETVPVQRDL--SQAQCQ-KE-----IEHMPPS-EQGKV------KK
YMDKQESSKGRLSQLESENLLLRQQLDDLQNKK---ESQQKRVINIQD----QFQNTVKS
LQAKS-EKQYLMLEERNKELTKEY-SHLKESINQYENEAMEREV--VVEQLQQELADS--
--LKKQ------SLSEASLELMLRDCAKLEDERQDLKKKVHQMTSK-A------------
------------------------------------------------------------
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-----------------------------

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-----------SF--------------------------------------AQHPS----
L---KPSTKMEDPAVKGAVP-------RK--KV---------------------------
-----------------------QT-L-------------REEQALLV-------ASEEE
QERHER------------------------------------------------------
--------------------------------------SEKKQPQCTLKQENEEKANVNM
LY-KKHREE----LERKEKQ------------------HEKEVEAK-QLEPTVQSLEMKP
KTARNTPH----------------------------------------------------
----------Q-DFHNHEEIKD---LMDE------ICILETDIAILRQEICTMKNDNLEK
ENEYLKDINIIKERNAALEKSIKLNEE-IT--------KTAFQDQQELNDL-KA------
ENKRLNSE-----------------------------------LLKENESK---------
--ARLEAEIESYQARLAAAISKH--SESVKTERNLK----LALQNTQDI--SVQVKMSSD
ISEVEDKNEFLT--------------------------E-QLSKAHIKFNT--LKDKFRK
TG-DTLRKKSLA-LET--LQNDL--SQTQQQIKE-----MKEMYQN-AEAKV------SN
STGEWNCVEERICQLQRENLWLEQQLDEVHQKE----DHKEIVINIQR----GS------
--IES-GKKDLLLEEKNKKLMNDY-DHLKESLFQYEREKAERVV--SINEEKY-FQTS--
--RKKI------------------------------------------------------
------------------------------------------------------------
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-----------------------------

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-------------------------------------MLQDELAMLRLEIDTIRNQKQ--
EKRYCEDTETEKEKNDSLQNAIKLNE----------------------------------
---------------------------------------------DEKLNR-----------ERLEAKLQSYRARLATAIQDR--DQSQASKRDLE----LAFQRAKDEWCHLQDKMNFEMSNLKDNNEVLS--------------------------Q-QLSEVESKFNA--LEIELQHTR-DALREKTLA-LEH--LQRNP--KQTQGQKKE-----IEQKSQN-EHGKV------NKYIGKHESLEEKLSQLQSENMLLREQLDDAYSRV---ECKEKTIIDLKD----QVQVIVRMVRVAG-EKRNLLLREKNKELINKC-KQIMERAFRYEDEKEEREL----------------------------------------------------------------QEAKELQTKIVRCIQK-----------------------------------FRDDIKKLEVENAELKVTVKEQAGQIEQLQ----KDLLSSSSCGDE-----------------------------------------------------------------KEN---L----KKC---MELKQPLQFR-LDQEVKKNEELEKETTGLVIL----EQDWKL--------------NLQDV-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DEKLNR---------
--ERLEAKLQSYRARLATAIQDR--DQSQASKRDLE----LAFQRAKDEWCHLQDKMNFE
MSNLKDNNEVLS--------------------------Q-QLSEVESKFNA--LEIELQH
TR-DALREKTLA-LEH--LQRNP--KQTQGQKKE-----IEQKSQN-EHGKV------NK
YIGKHESLEEKLSQLQSENMLLREQLDDAYSRV---ECKEKTIIDLKD----QVQVIVRM
VRVAG-EKRNLLLREKNKELINKC-KQIMERAFRYEDEKEEREL----------------
------------------------------------------------QEAKELQTKIVR
CIQK-----------------------------------FRDDIKKLEVENAELKVTVKE
QAGQIEQLQ----KDLLSSSSCGDE-----------------------------------
------------------------------KEN---L----KKC---MELKQPLQFR-LD
QEVKKNEELEKETTGLVIL----EQDWKL--------------NLQDV------------
------------------------------------------------------------
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-----------------------------

------------------------------------------------------------
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------------------------------------------------------------
-------------C--ATGQPEMVRLLVSRKCELNL--CDREDRTPLIK-----------
-AVQLRQEACATILL-QNGADPNITDFF----GR--TALHYAV-YNEDTSMIEKLLSYGA
NIEECSKV----------------------------------------------------
------------------------------------------------------------
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-----------------------------

------------------MKSLFGLRNA--------------------------------
------------------------------------------------------------
--------------------SPRLDGGGFGR----------------GARTSCVPGPGYY
VRDKDLGK-----IHK---------------AASAGDV----------------------
AK---VQQVLLLGK-SG--LN-DRDKM------------------NRTAL----------
----------HLAC--ASGHREVVTLLVERKCQLNL--CDRENRTALIK-----------
-AVQCQKEDCATILL-EHGADPNLQDSF----GN--TALHYAA-LGQNQSV-AKLLLHDA
NIEADNEN-G---LTPVL------LAVNENKQQMAD-FLIK-EAN--------LCAL---
-SKMQS-------NH-QATSEY--TLEN--IPKSPFQQDSPXXXXXXXXXXXXXXXXXXX
XXXX-XXX-XXX--------XXXX------------------XX-X--------------
------------X-----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------XXXXXXXX--XXXX--------------X----X--XXXXX-X---------
--------XXXXXXXXX-------------------XXX-XXXXXXXX----XX------
--XXX-------------------------------------------------------
-------------------------------------------XX---------------
------------------------------------------------------------
-----------------------------XXXXX--------------------------
----------------------------------XXX-XXXXXXXX-----------XXX
XXX---------------------------------------------------------
-------------------------------XXXXXXXXXXXXX----------------
-----------------------------------XXXXEESTKPETSPVG---------
---EGIDIAE----WTPHE--------------QNANLF-------------NANETPLK
RKS----NLMTISLLGEEDLEDIEANLKIEXX-XXXXXXXXXX---------------XX
XXXXXXXXXXXXXX---X------XXX----------------------------MFYIP
SCMSGLSNFKMAKVEDTRNI--------------GIPVAPLDLFENYHHLKPS----IEL
-KDSVSNK-----------------------------IVEIK------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------DAQT----------------
--------------------------------------------S---P-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------PA
ELNLDMTLDETQERLNG-------------SENSYSQIE--------EEKKKRK------
---------------------------NNEIKAS---ENTYEAAH---------------
-------AGFSQ---------QRKNRKTD----NQQFPISETEDS---------------
---------DSIVLSLPMKE-IKEKES-EKNWTPKASVIPLVFERPKSR-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------VSAESLCEENDDSSLSE-
-------------------ADQKDE------------------VRLQINSVD--------
------------------------------------------------------IP-DDI
TQSSETTSENCDMP--YSNYNNSMLLIEQLG---KD--CKD--SVSLLKIQDA----ILS
YERLIEL---KKNH-------------------CELLTGKNKKMRNK-------------
--ISSLQ----KKLSEAK---ETKSQLEHQKVE-WEQEL--CNLRFTLKQEEEKRRSADM
LY-EKIREQ----LRKTEEQ------------------YCQEVEVKQQLELNLRTLDMEL
RTVRNHLS-QXXXXXXXXQRQLSREQNARILQEGIL-----TNHLSK--QKELEMTH---
-KKLNSEVSD-----SYEKGNN---MLHK------HHMLQDEIVTLKLEIDTVKNQNQEK
EKKYLEDIEMIKEKNEDLQRTLKRTEESLT--------ETVFQYSGQVNVL-T------A
ENAMLKSQ-----------------------------------LETAKQNK---------
--ERLETELETYRSRLATATQDH--QQSQTSKRELE----LSFR-TKEEWARLQEKMFDV
----LKENEVLS--------------------------X-XXXXXXXXXXX--XXXXXXX
XX-XXXXXXXXX-XXX--XXXXX--XXXXXXXXX-----XXXXXXX-XXXXX------XX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXNKA---ESKEKTVMSIHG----QFQDAVKR
LQVES-EKKGLMLEERTKELINDC-NHLKETICQYESEKAEREV--VVRQLQQELADT--
--LKKQ------SMSEASLEVISRYRSSLEDEKKDLKKKVSQIR---LQEVQGQHTEAIR
C-----------------------------------VEKMKDHIQKLEIENGKLNITVQK
QASKIEQLQ----KNPLST-----------------------------------------
------------------------------SSLDHL------------------------
------------------------------------------------------------
---------------------------------TELQTVSSKCQRLDAQ-----------
-NQML--HE-----REMQKECEKLEKDIKQIEPEVVNLKSH---VEK-NMVEPSPSRQY-
KQEIEERARQEI-VEKLKEVNL---ILQAQAA-SQENLEQ-LREN-NNASVRSQLEVRIK
DLESEL-TRMKTYQE------ESSKIELEKYK----QLFLKEFKVRKSLA-NELKXXXXX
XXXXXXXXXXXXXX---XXXXXX------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXX-XXXXXXXXXXX-XXXXXXXMQQELEKNITRELEEA-AAE-----FES-----G---
----------------------SISSPGST---------NGS----NLTQDLLMQTSQEY
VEILKKN--YLI------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------MKKIFGYRSEKG------------------------------
--------------------------------------------------------ESPL
DSSI--------------SLGRD--------R----------------GHRRTSFQPGYR
IRDRDLKK-----IHK---------------AASEGNV----------------------
AK---VQQVLLLRK-NG--LN-DRDKK------------------NRTAL----------
----------HLAC--ANGHSEVVALLLERKCQLNL--GDSENKTALMK-----------
-AIECQEEECAALLL-EHGADPNVTDVN----GN--TALHYAV-FCQNVSLAAKLLSYNA
NLEARNED-G---LTPLL------LGISERKQQMVE-FLVKKEAD--------IHAV---
-DKMKS-------IC-ELISEY--KEKR--PKTTP-ENSN--------------------
--PA-AKS-SEEDSLSRFSNKP-G------VDS-WPTSDDDMLG-SE---TKK---EP--
--KPNLAKLMKAFQQSKRNQAEC-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------G--------------
----------IV--RR--E-------------------------NTTLSEN---------
------------------------------------------------------------
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-----NNS-------------------------------------------DS-------
------------------------------------------------------------
-------------------------------------------------EI--EDVA-ET
LPKPS-------------------------------------------------------
-------------PGVQGF-------------------------------------S-HP
A-----------------------------------------------------------
------------------------------------------------------------
--------------------SPRPDPLPKPL-K---------------------------
---------------------------------------------------TLAGLGLA-
------------------------------------------------------------
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-----------------------------

------------------MKKIFHFGNRKG------------------------------
--------------------------------------------------------ESPL
GSST--------------SPGRD-------------------------RRNSGNSPPGYH
IRDKDLKK-----IHK---------------AASVGDV----------------------
AR---VQQILLLRK-NG--LN-DRDKM------------------NRTAL----------
----------HLAC--ANGHSAVVTLLVERRCQLNL--YDNENRTALMK-----------
-AVQCQEEACVTILL-EHGADPNLTDGS----EN--TALHYAV-LAENTSIAAKLLSYNA
SIEARNKD-D---LTPLL------LAVSENKQQMAE-FLVKKEAN--------IHTA---
-NKVK-------------------------------------------------------
------------------------------------------------------------
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-----------------------------

------------------------------------------------------------
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----------------------------------------------RTPL----------
----------HLAC--ANGHSNTVSLLTEKQCKVNV--WDCENRSPLTK-----------
-AVPCDKGSCATILL-EHSADPNLVDLD----GN--TALHYAA-CCQSVSLAAKLLKHKA
NLEAQNMD-G---FTPLL------LAITENNAEM-------NGAD--------VNAS---
-DKNQR-------TA-LMIAFS--DEPT--RLVSL-------------------------
--LL-QQE-VDL--------SCQD------IYG-FTAEE---YA-SF---NGF---TM--
------------------------------------------------------------
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-----------------------------

----------------------MFDD----------------------------------
--------------------------------------------------------YEPE
RWPT--------------LRE----R---LC-------------------SDGFSFPEYR
IKLSHLRR-----IHR---------------AIFYGRL----------------------
EK---LEY-LLLT-RSD--VN-KRDKK------------------ERTPL----------
----------HLAC--ATGQPDMVSLLVSARCELNL--YDRECRTPLIK-----------
-AVQLRQEVCATILL-KNGADPNIMDFF----GR--TALHYAV-YNEDTSMIETLLFYGT
DIEECSKY-E---YQPLL------LAVSRAKVNMVE-FLLKKNAN--------VNAV---
-DFLNR-------SA-LILAVT--LGEK--DIVIL-------------------------
--LLKQHN-IDV--------FSRD------AYG-KTAED---YA-IE---THN---KV--
--IFRLISEYKREKTSEELPINS-----NPVSSQ----------------KQPALKATSE
KKDSASNVATETKDGEKSGTVSSQKQPVL-------------------------------
---------KATSEKKDSV----SNIATEIKDGEKSGTVLPPAKECLNRSLCRPDNIAQP
VTEDEFDLESEIISKPYIPKRRIISPQSAEDVLPPAEECLNRSLCRP------DSVAQP-
--------VTEDEFAL--ESEIISKLYIPKRKIISPKSIEDV--LPPVEECFDRSLYIPD
IVAQPVTKNEFDLESEE-------------------------------------------
-------------------------------------------EK------------S--
------------------------------------------------------------
------------------------------------------------------------
-------------------------------LSA--------------------------
---------------------------T--------------GEEA--NVSPEQTPLF--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------THTVED
RDHISTRFSGSMDSLTSSEGSSERPPLSTLTP-K--------------------------
----------------------------------------EADPSSKVAIRRKDS-----
------------------------------------PPPEKVSSEKQPACKVT----SDQ
-NDSILNI-----------------------------ATEIKDGQKSGTVSSEK------
------QPALKATSEKNDSVSNIATEI---------------------------------
-----------EEGPTSGTVS--------SRKQPVLKVTSDEKDSVS--NI------ATE
IKDGQ---QS--GTVSSQKQPTLKATSDKED----------SVSNIATKIKDA-------
------QISGTVSSQKPPAWKAT---SDKKDSLVNIATE-----------------INDG
QQSGTVSSQKQPALK------------ATSDK---EDSVSNIT----------TEVKDGQ
QSGTVSPQKQSAWKVIFKKKAPVLNIA------TRIMAGRKSGTVSSQKKKALKTTSDKE
DSVSNTATEIKDEQQS-GTVSSQKQPVLKVTSDEKDSVSNTASEIKDGQESATVSSQKQP
DLKATSDKEDSVSNIAT---EIKDAQISGT---------VPSQKP----------PALKV
------ISDEKDSILN--------IATEIKDGQESGTVS----------S---QKQP---
-T---------L-------KATSDKED-SV-SNI-ATEIKDGQQS-----G---TVSSQK
RPTLKATS---------------DKEDSVLNIATEIQDGQQSGTVSSQKQPALKATS---
-----------------DKEDS-VSNITTEIKDAQISG----------------------
------------------------------------------------------------
-----TVPSQKPP-----------------------------------------------
---------------------------------------------------ALKVTSDKK
VPVSNTA-TEIKDAQESGTVSS--------------------------------------
-----------QKQPA-----------LKATSDKEDSVSNIATEI-KD------------
AQISGTVSSQKPPALKATSDKKDSVSNIAT-------E--I----------MDGQKSGTV
-----------------------------------SSQKQ--PPLKATSDKKDSVSNITT
------------------------EIKDGQISGTVSSQKKKALKATSDKE----DSVSNT
ATERKDGQQSGTASPQK---------Q-------SAWKVIFKKKVPVLNTATRIMAGQK-
-------------------------------SGTEYPENLPTLKATIEN-----------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------KD-SVL-NTATKMKGVQTSTPA
EQDLEMA------SEGEQKRLEDYEN-NQPRVKNQIH---------SRDD----------
-------------------------------------------------------F-DDI
IQSSQIASE-DD--SLCSNCKKVILLIDQHE---MK--CKD--CVRLSKIKNA----FRF
CKRSIKL---KDNH-------------------CERLIVKIQKMKNK-------------
--VSVLR----KRLSEKE---EIKSCLEHEKLE-CEQEL--CSVRFTIQQEKEKRRNVEE
LH-QKVREK----LRTTEEQ------------------HRIEVDVTEQVKLALKSLEMEL
KSVGKNS-----------------------------------------------------
---------NQ-ISDTDKKEED---LLHE------NHLMEDEIATLRLEIDTIKNQNL--
EKKYLKDFEIMKRKHEDLQKTLKRNGETLA--------KTIADYSVQLAAL-T------D
ENATLRSK-----------------------------------LEKETQTR---------
--QILETETESYRCRLNAALSDH--DQSHSSERDQE----LAFQGTVDKWCHLQENSNSC
-------VLTLS--------------------------Q-QLSKAESKFRV--LETELHY
TR-EALKEKSSV-FEH--VQREL--NQKQCQMKD-----IEKMYKN-EYDKM------EK
CIEKQ----ERFCQLKKQNMLLQQQLDDARNKA---DNREKAILNIQA----RCDARVQN
FQAEC-RKHRLLLQEDNKRLVNEL-NHLKEKECQNEKEKAEREV--VVRQLQQKRNDV--
--LNKQ------SSTKALLDASSRHCVHLENEMQDSRKKLDQIRSQ-FQEIQDQLTATIR
C-----------------------------------TKKTEGHAHKLEVENAMIRKTIKK
QDDQIERLE----KILQRS-----------------------------------------
------------------------------SLM-------------------LPVFR-K-
------------------------------------------------------------
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-----------------------------

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----------------N-----VPK--------------PSLTKLMTA------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------F--QQSKKNIE---AKRGTVRP
ENTMLFEDDN----------SDSENEDVVETLPKPSIKVQGFSPPA--FPSPEP-LLKPT
VRSF--------------------------------------------------------
------------------------------------------------------------
--------------------------------ADLDLTKEETTKSATGKKE---------
---NGIDIIQ----STPQEQT--------------NNDNLI-------------SVEGAH
KDN----RSDLMSALGLGEEDGVESPWDSESI-SESLPQKYVD--H-------------L
SGAA--------------------------------------------------DQ----
------------------------------------------------------------
-------------------------------------------KG-----KNMLNEQV--
ED---VFYV------PS---CMSGSRNFKMAK------L--E------------------
------------------------------------------------------------
------------------------------------------------------------
----DKRNVGIPV---------------AHMDS---------------------------
----PEKC----------------------------------------------------
------------------------------------------------------------
------PHLKPTIDVQ------DSVPKKAG------------------------------
--------GRK-------------------------------------------------
------------------------------------------------------------
----DART-------------SRS------------AEVD-LEIT-SEE-----------
----------------------------------EQ-ER-L--DG-S-------------
--------------------------------------ENNHLQVEEEKKKH---KSSEM
EISE-----------NIDAAAAA-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------AENGL-IQ-Q----------
--TSGR------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------ADKQHFPVMENED----------------
-------SV--SAPGLHMKE-VKKTKDE--KWTPKESVITPMF-----------EK----
----------------------ADSLPGGLL-----------------------------
-----------------------------------QV--NDDS----S------------
------------------------------------------------------------
----------------LSETDQDD---GRPAKKTSNEKNK---VKKQINSLD--------
------------------------------------------------------DL-ADL
TQSSETASEDCELP--YSNYMNSMLLIEQLG---VD--CK--DSVSLLKIQNA----VLS
YERLIEL---KKNH-------------------CELLTGKIKKMENK-------------
--VSGLQ----KELSETK---EMKSQLEHQKVE-WEREV--CSLRFTLKQEEEKRRTADK
LY-EKIREQ----LRRKEEQ------------------YSQEVEMKQQLELTLRTLDMEL
RTVRNNLN-QVVEERNDTQRQLSREQNARILQDGIL-----TNHLCK--QKEIE------
--MAHKKLNTE-VSDSHDKEKD---LSHK------NHMLQDEIAILRLEIDTIKNQNKEK
EKKYFEDIERVKEKNDDLQKTIKLNEETLA--------KTIFQYNGQLNVL-TA------
ENTVLNSK-----------------------------------LENERQNK---------
--ERLETEVESYRSRLATAVHDH--DQSQTSKRDLE----IAFQRARDEWFRLQDKMNFD
ISNLKDSNEILS--------------------------Q-QLSKAESKVNN--LEIELHQ
TR-DVLREKTLV-LEG--VQRDL--SQTQCQKKE-----IEQMYQS-EQGRV------NK
YIGKQESLEERLAQLQSENMLLRQQLDDAHNKA---DSKEKTVINIQD----RFQDIVTK
LQAKS-EKQGLMLEERNKELMDEC-NHLKERMYQYENEKAEREV--VVRQLQQELADT--
--LKKQ------SMSEASLEVTSRYRISLEDETQDLKKKLGQIRSQ-LQEAQDRHIEAVR
CAEK-----------------------------------TQDHVQKLEIENAKLKVTVKK
QMGKIEQLQ----KNLLGTSTSE-------------------------------------
-------------------------------DE---KE-QLKKF---MELKQSLEYS-LD
QEMKKNSELEKEITGVKK-----LLKVTR--------------RKLND------YENGE-
---L-SFQGDLKTNQIEMDIQMNMLKHKIDDLTAKLETASSKCVHLDAE-----------
-NQVL--QQKLLSMKALQKKCEKLDKNKKKLEQEVVNLRSH---IEM-NMVEHGQVEQY-
RREIEERARQDI-VEKLKEVNL---FLQTQAA-AQENLEQ-LREN-NNASIRSQMELRIR
DLESEL-SKMKISQEDF------NKTELEKYK----QLYLEELKVRKSLE-NKLNKTNER
LAETSTELLLKKEQ---NRSLLS------ALTARPVLEPPCAGNHNSSLVLNRNLTPRED
LVI-PTSRPRPSNNS-METYLTKMQEELEKNITRELEEA-AAE-----FES-----G---
--------------------PCRASPLGST---------DES----NLNQDLVLKTSQEY
VQILKKN--YMI------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------MKRIF------K------------------------------
---------------------------------------------------------GHS
PW----------------------GFLSFRH------------------A-ENQEPPRYL
TGYTPVKR-----IHK---------------AASMGDI----------------------
PQ---VQKLLEFG-NID--VN-ITDRK------------------KRTAL----------
----------HYAC--AHGQSEMVSLLLWYDCNIEA--RDREESTALIK-----------
-ATQRQHEICVKILL-ENGADPNAVDAY----HI--TALHYAV-YNNDTAIAAKLLSFNA
NTEIKTKN-G---YTPLI------LAVLENKQEMVE-LLLRAAAN--------INAL---
-DNCKR-------SA-LIHAVR--IQSK--NMISL-------------------------
--LL-QQG-ADP--------SLVD------IYG-ATAQS---YA-VF---ETF---Q--V
LSQ---------------------------------------------------------
SPGPSCPELTTKEDKQS-FD----------TKDGCIPHSHHIKEDNQEMEENTDDKLGSP
--------------------------------------AAL-KHKEKELENCEE------
------CNSEADT-------------------YPESYSKTSSAQRRSNSEPTEVDDEPSF
--------------ST--KPPV-------------------A--QSPMFTES--SLWV--
-----------GYP--A------------------DWPEPVKFSRQPAVYNPT-------
-------------EW--REDMESRSV----PREES-----K-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------QQVAI---FPEGK-------------------------------------
------------------------------------------------------------
-----------------------------------EAD----VQT---QELLSRVFKESG
DNDPNLPAIE-NTKDELV----------SL------------------------LAPLEE
NKPQMT----EFP----------------------------------------------L
IEAAKFQTDVQL---DRCPCF-------LLSLRNSL---SGT------------------
------------------------------------------------------------
--------LD--------------------------------------------------
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-----------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------MTKRKKTIN--LN-IQDAK------------------RRTAL----------
----------HWAC--VNGHEEVVTFLVDRKCQLDV--LDCEHRTPLMK-----------
-ALQCHREACANILI-DSGADLNLIDVY----GN--TALHYAV-YSEILSVVAKLLSHGA
VIEVHNKA-S---LTPLL------LSITKRSEQIVE-FLLIKNAN--------ANAV---
-NKYKC-------TA-LMLAAC--HGSS--EIVGM-------------------------
--LL-QQN-VDV--------FAAD------ICG-VTAEH---YA-VT---CGF---HH--
--IHEQIMEYIRKLSK-N-HQNT-----NPEGTS------------------------AG
TPDEAAPLAERTPDTAESLMEKTPD-EAAPLVERTPDT----------------------
-----------------------------------------------------AESLV--
--------------------------------------------EKT------PDEAAS-
--------LVEGT-SD--K--I---QCLEKAT-SGKFEQSAE--ETPRE--------ITS
PAKETSE--KFTWPAKG------------------RPRKIAWEKK-DTPREIM-------
------SPAKETSEKF-TWAAKGRP-RKIA----------WEKKE------------T--
------------------------------------------------------------
------------------------------------------------------------
-------------------------------PVK--------------------------
---------------------------T--------------GCVA--RVTSNKTKVLEK
G-------------RSKMIACP--------------------------------------
------------------------------------------------------------
-----------------------------------TKESSTKASAN--------------
------------------------------------------------------------
---------DQRFPSESKQEEDEEYSCDSRSL-FESSA----------------------
----------KIQVCI-----------------------PESIYQKVMEINREVE-----
------------------------------------EPPKKP-----SAFKPA----IEM
-QNSVPNK-----------------------------AFELKNEQ--TLRADPM---F--
PPE-SKQKDDEENSWDSESLYETVSQK---------------------------------
------------------------------------DVCLPKATHQK--EI---------
---DK---INGKLEESPNKDGLLKATCGMKV----------SILTKALELMDM-------
------QTFKAEPPEKPSAFEPA---IEMQKSVPNKALE-----------------LKNE
QTLR--------------------------------------------------------
-ADEILPSE-SKQKDY--EENSWD------------------------------------
----------------------------------TESL----------------------
--YETVSQKDVCLPKAT---HQKE---------------IDKINGKLEES-----P----
-----------------------------------------------------DKDG---
-L---------L-------KATCGMKV-SI-LTK-ALELMDMQTF-----KAE---PPEK
PSAFEPA---------------IEMQKSVPNKALELKNEQTLRAGE----ILPSESKQK-
---------------------DDEEN------SWD------------S---E---SLCET
VS---------------------------------------------------------Q
KDVCLPKATRQ-------------------------------------------------
----------KEIDKINGKL----------------------------------------
------------------------------------------------------------
-------EESPDKDGL-----------LKATCGMKVSILTKALEL-MDM-----------
-QTFKAEPPEKPSAFEPAIEMQKSVPNKAL-------ELKNEQ----------TLRAG--
------------------------EILP--SESKQKDDEE--NSWDSESLCE--------
------TVSQKDVCLPKATRQKEIDKINGKLEGKNLSI----------------------
----------------------------------------L-------TKALELMDMQT-
-------------------------------FKAEPPEKPSAFEPATEM-----------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------QR-SVP-NKALESKNEQTLRA-
-----------------------------DQMFPSES---------KQKN----------
-------------------------------------------------------V-EEN
SWNSESLRETVSQKDVCLPKATHQKEIDKIS---GK--LED--STSLSKILDA----VHS
CERAREL---QKDH-------------------CEQLTGKMEQMKKK-------------
--FCVLK----KKLSEAK---EIKSRLENQKVK-WEQEL--CSVRLTLNQEEEKRRNADI
LN-EKIREE----LGRIEEQ------------------HRKELEVKQQLEQALRIQDMEL
KSVGSNL-----------------------------------------------------
---------NQ-VSHTHENEND---LLRE------NCMLKKEIAMLKLEIATLKHQYQEK
ENKYFEDIKILKEKNAELRMTLKLKEESLT--------KRASQYSGQLKVL-I------A
ENTMLTSK-----------------------------------LK-EKQDK---------
--EILETEIESHHPRLASALQDH--DQIVTSRKSQE----LAFHIAGDACL--QRKMNVD
VSSTICNNEVLH--------------------------Q-PLSEAQRKSKS--LKINLNY
AG-DALRENTLV-SEH--AQRDQ--CETQCQMKE-----AEHMYQN-EQDNV------NK
HTEQQESLDQKLFQLQSKNMWLRQQLVHAHKKA---DNKSKITIDIHF----LE------
----R-KMQHHLLKEKNEEIFNYN-NHLKNRIYQYEKEKAETEV--SIKKYKYLSN-F--
--LK---------ESLKSYLALAKC-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
-----------------------------

------------------MKKLFGFWRR--------------------------------
--------------------------------------------------------KDEA
-------------------HSCSSDL-----QM----------GAA--T-ICPPSHPGYN
LRDKDLRK-----LHK---------------AASVGDL----------------------
EK---VQVYLQFKK-HD--VN-GRDKK------------------HRTPL----------
----------HLAC--ANGYANIVSLLVEKQCNINV--LDSEKRSPLIK-----------
-AVQCQKESCASILL-DHDADPNLADSD----CN--TALHYAV-CGQSVSLVEKLLEHKA
NLEAQNKN-G---YTPLL------LAITENNEEMVE-FLLKRGAD--------VNAS---
-DKSQR-------TA-LMIALS--DEPT--GLVSL-------------------------
--LL-QQD-VDL--------SCKD------IYG-FTAEE---YA-SF---NGF---TM--
--YHQLIANYAKKEKI--KQTSY-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------S--------------
----------EN--TT--L-----------------------------WTTF--------
-----------D------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
--SEELP-----------------------------------------------------
------------------------------------------------------------
-------------------------------------------------EG--R------
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-----------------------------

------MALSQTLVLPGSLLHLRGLRLAIG------------------------------
----------------------------------------------------------GL
GGGQG-------------YGHAEPGPWKDQG----------------Q--EQGQCRAKAR
TR----------------------------------------------------------
--------------------D-RSALG------------------PVTAL----------
----------HLAC--AHGHPGVVADLVARKCQLNL--TDSENRTALIK-----------
-AVQCQEEVCASILL-EHGADPNVRDMY----GN--TALHYAI-DNENISMAGKLLAYGA
NIEAKSQD-E---YTSLL------LAINRKKEQMVT-FLLKKKPD--------LTAI----DNFGR-------TAL-ILATC--NGS-------------------TG----------VVFQLL-QHN-VDV--------CCRD------TSG-WTAED---HA-IA---YNF---Q-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AIRR--------------LISEYK-------------------------------------------------------------------------------------------------------------------------ANK-------------------------------RR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------K---R----LQNRNPEQDLKLISEGKQDRLQG-------------CENNQPQVA--------EKMRKCR---------------------------------NKKMKVS---RNLHADDSDND---------------DD-DDELIQ---------ERRGRKSD----DRQFPRQKREEY------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NRLARKTCNEKNK---VKRDLYSKD--------------------------------------------------------------DL-NDIIWSPETSSEDDDLP--YSSDKNFMLFIEQHG---ME--HKD--FVSLSKTKNA----ITACERSIEH---KKCN-------------------CEQLKVKFQKMKNK---------------ISMLQ----KELSETD---ETKSQLEYQNLE-CKQKL--CNFSCILQEEEEKRRKAEELY-EKDTEE----LKIMEEQ------------------YRTQTEVKKQLQLTLKSLEVELKTVRSNSN-ESS--------------------------------------------------------------HTHEKERD---LWQE------NHLMRDEIARLRLEIDTIKYQNQETEKKYFKDIEIIKGNNEDLEKTLKLNEETLT--------KTITRYSKELSAL-M------DENTVLNLE-----------------------------------LEKEKQST-----------QRLKTEMESYPCRLAAALHDH--DQCQSAKRDRQ----LAFQSTVNEWCHLQENINSHI-------QILS--------------------------Q-QLSKVESTSSG--LETELHYER-EALKEKTLA-VEH--MQEVL--SRTQCQLKD-----IEHMYQN-DQPIF------EKYVRKQQSVEDGLFQLQSRNLLYQQQCNDADKKA---DNQEKTIINIRA----KCEDTVEKLQAEC-RK----LEENNKELMKEC-TLLKERQCQYEKEKEEEEV--VMRQLQREVGDT----LNKQ------SLSEAMLEISSQCHHNLEDETRDSKKKLDQLRSQ-VCMKLSMSTVTL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HLAC--AHGHPGVVADLVARKCQLNL--TDSENRTALIK------------AVQCQEEVCASILL-EHGADPNVRDMY----GN--TALHYAI-DNENISMAGKLLAYGANIEAKSQD-E---YTSLL------LAINRKKEQMVT-FLLKKKPD--------LTAI----DNFGR-------TAL-ILATC--NGS-------------------TG----------VVFQLL-QHN-VDV--------CCRD------TSG-WTAED---HA-IA---YNF---Q-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AIRR--------------LISEYK-------------------------------------------------------------------------------------------------------------------------ANK-------------------------------RR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------K---R----LQNRNPEQDLKLISEGKQDRLQG-------------CENNQPQVA--------EKMRKCR---------------------------------NKKMKVS---RNLHADDSDND---------------DD-DDELIQ---------ERRGRKSD----DRQFPRQKREEY------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NRLARKTCNEKNK---VKRDLYSKD--------------------------------------------------------------DL-NDIIWSPETSSEDDDLP--YSSDKNFMLFIEQHG---ME--HKD--FVSLSKTKNA----ITACERSIEH---KKCN-------------------CEQLKVKFQKMKNK---------------ISMLQ----KELSETD---ETKSQLEYQNLE-CKQKL--CNFSCILQEEEEKRRKAEELY-EKDTEE----LKIMEEQ------------------YRTQTEVKKQLQLTLKSLEVELKTVRSNSN-ESS--------------------------------------------------------------HTHEKERD---LWQE------NHLMRDEIARLRLEIDTIKYQNQETEKKYFKDIEIIKGNNEDLEKTLKLNEETLT--------KTITRYSKELSAL-M------DENTVLNLE-----------------------------------LEKEKQST-----------QRLKTEMESYPCRLAAALHDH--DQCQSAKRDRQ----LAFQSTVNEWCHLQENINSHI-------QILS--------------------------Q-QLSKVESTSSG--LETELHYER-EALKEKTLA-VEH--MQEVL--SRTQCQLKD-----IEHMYQN-DQPIF------EKYVRKQQSVEDGLFQLQSRNLLYQQQCNDADKKA---DNQEKTIINIRA----KCEDTVEKLQAEC-RK----LEENNKELMKEC-TLLKERQCQYEKEKEEEEV--VMRQLQREVGDT----LNKQ------SLSEAMLEISSQCHHNLEDETRDSKKKLDQLRSQ-VCMKLSMSTVTL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HLAC--AHGHPGVVADLVARKCQLNL--TDSENRTALIK------------AVQCQEEVCASILL-EHGADPNVRDMY----GN--TALHYAI-DNENISMAGKLLAYGANIEAKSQD-E---YTSLL------LAINRKKEQMVT-FLLKKKPD--------LTAI---
-DNFGR-------TAL-ILATC--NGS-------------------TG----------VV
FQLL-QHN-VDV--------CCRD------TSG-WTAED---HA-IA---YNF---Q---
------------------------------------------------------------
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----------------------------------------AIRR--------------LI
SEYK--------------------------------------------------------
------------------------------------------------------------
-----ANK-------------------------------RR-------------------
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---------------------------------------------K---R----LQNRNP
EQDLKLISEGKQDRLQG-------------CENNQPQVA--------EKMRKCR------
---------------------------NKKMKVS---RNLHADDSDND------------
---DD-DDELIQ---------ERRGRKSD----DRQFPRQKREEY---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------NRLARKTCNEKNK---VKRDLYSKD--------
------------------------------------------------------DL-NDI
IWSPETSSEDDDLP--YSSDKNFMLFIEQHG---ME--HKD--FVSLSKTKNA----ITA
CERSIEH---KKCN-------------------CEQLKVKFQKMKNK-------------
--ISMLQ----KELSETD---ETKSQLEYQNLE-CKQKL--CNFSCILQEEEEKRRKAEE
LY-EKDTEE----LKIMEEQ------------------YRTQTEVKKQLQLTLKSLEVEL
KTVRSNSN-ESS------------------------------------------------
--------------HTHEKERD---LWQE------NHLMRDEIARLRLEIDTIKYQNQET
EKKYFKDIEIIKGNNEDLEKTLKLNEETLT--------KTITRYSKELSAL-M------D
ENTVLNLE-----------------------------------LEKEKQST---------
--QRLKTEMESYPCRLAAALHDH--DQCQSAKRDRQ----LAFQSTVNEWCHLQENINSH
I-------QILS--------------------------Q-QLSKVESTSSG--LETELHY
ER-EALKEKTLA-VEH--MQEVL--SRTQCQLKD-----IEHMYQN-DQPIF------EK
YVRKQQSVEDGLFQLQSRNLLYQQQCNDADKKA---DNQEKTIINIRA----KCEDTVEK
LQAEC-RK----LEENNKELMKEC-TLLKERQCQYEKEKEEEEV--VMRQLQREVGDT--
--LNKQ------SLSEAMLEISSQCHHNLEDETRDSKKKLDQLRSQ-VCMKLSMSTVTL-
------------------------------------------------------------
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-----------------------------

-----------------MKNLVHG----IK------------------------------
---------------------------------------------------------EKT
PMGF--------------CDVPRKNLLDYLR--------------DM-----KSISVPNE
PRYKPLKK-----IHL---------------AASEGDA----------------------
ER---LQRMINLG-KHS--VH-DRDYK------------------QRTAL----------
----------HFAC--AYGHVEVVSVLLKNNCDIDA--IDMNSVTPLMK-----------
-AVQNWTYECVRTLL-KHGADPNRMDKD----GN--TSLHYAV-SEDNQTLAKCLIKYSA
DMEQKNKD-G---FTPLL------QALKENKIEMAK-FLVKNGAN--------IHVF---
-DEMKR-------NT-LLYAIR--WDSK--DMVSL-------------------------
--LL-NEG-IDF--------FFKD------VFG-WTALR---YA-IE---GTS---K---
-GSREILMDYDEKLRIKHKKGSSAYKNSEDN---------------------SLAKYPD-
GPTSAFTLPKSKED-SDFSDKLNS------STNVLDKCPSNLCGAGDQRDKNETKGTMTA
Q------VWMHPTL----------KSSIEEKV-----PILNEAGKTAESHHFTI------
------ESDLEI-----------------------------ESLEETLSDENEDKQ--SL
--------SEDGDFSV--MTDE-----------SGQK---DT--SRHNTGQV--WMFP--
-----------NKKSST------------------ERKMPIL-NKVGKMVNLH-------
-------------HFKIESDLETESLEETLSGGSE-----EK------------------
------------------------------------------------------------
------------------------------------------------------------
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----------KSLV----------------------------------------------
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-----------------------------

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-------V-----LHA---------------AAACGDL----------------------
AL---LQRRQWLRK-LC--IN-WGDAE------------------GRTPL----------
----------HFAC--ANGHVDVVQFLLRKKCKLNP--RDNRKNTPLMK-----------
-AVVHKQEGCVVLLL-EHGADPNVTNHR----GN--TALHLAV-HAGSVSVAGILLQHNA
RIDAQNEM-G---CTPLA------LAVSCSRKEMIE-FLLEKGAN--------VNAR---
-DRSGR-------SI-CAIAAV--AGDT--DMIRLLLRHG--------------------
---------ADP--------FKKD------FTG-KSAKD---Y-----------------
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MVECLVKKEA----DIHAVDKMKRTALILAVNYECTDVVSLLLQRGADVFSQDVFGRTAE
EYSAISGFNIIC--ELISEYKEKRPK-TTPQKSNPVAAKS---SEE--DSLS--------
--------------RFSNKPG---------------------------------------
--------------------------VDSWPTSDDD--VL--GSETKKK-----------
----------P---------KPNLAKLMK----AFQ------------------QSKRN-
QTEHGIVRRESTNFSE-----NNNSDSEIEDVV-ETLPKPSPGV----------------
---------------------QGFSHP--------A---FPRP----------DPL----
----PKPLKTLAGLGLAKV-----------------------------------------
------------------------------------------------------------
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-----------------------------

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---------------------------------------EEPTKPGIGKKE---------
---NDIDIIE----SAPLEQT--------------NNDNLT-------------YVDEVH
KNN----RSDMMSALGLGQEEDIESPWDSESI-SENFPQKYVD--P-------------L
AGAA--------------------------------------------------DG----
------------------------------------------------------------
-------------------------------------------KE-----KNIGNEQA--
ED---VFYI------PS---CMSGSRNFKMAK------L--E------------------
------------------------------------------------------------
------------------------------------------------------------
----DTRNVGMPV---------------AHMES---------------------------
----PERY----------------------------------------------------
------------------------------------------------------------
------LHLKPTIEMK------DSVPNKAG------------------------------
--------GMK-------------------------------------------------
------------------------------------------------------------
----DVQT-------------SKA------------AEHD-LEVA-SEE-----------
----------------------------------EQ-ER-E---E-S-------------
--------------------------------------ENNQPQVEEERKKH---RNNEM
EVSA-----------NIHDGATDD------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------AEDDDGL-IQKR----------
--KSGE------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------TDHQQFPRKENKEY---------------
-------AS--SDPALQMKE-VKRTEKE--KRTSKESVNSPVF-----------GK----
----------------------ASLLTGGLL-----------------------------
-----------------------------------QV--DDDS----S------------
------------------------------------------------------------
----------------LSEIDEDE---GRPTKKTSNEKNK---VKNQIQSMD--------
------------------------------------------------------DV-DDL
TQSSETASEDCELP--HSSYKNFMLLIEQLG---ME--Y---------------------
------------------------------------------------------------
--------------------------------------------KFSLNQEEEKRRNADM
LY-EKIREQ----LRRKEEQ------------------YRKEVEVKQQLELSLQTLEMEL
RTVKSNVN-QVVQERNDAQRQLSREQNARMLQDGIL-----TNHLSK--QKEIE------
--MAQKKMNSE-NSHSHEEEKD---LLHK------NSMLQEEIAMLRLEIDTIKNQNQEK
EKKCFEDLKTVKEKNEDLQKTIKQNEETLT--------QTISQYNGRLSVL-TA------
ENAMLNSK-----------------------------------LENEKQSK---------
--ERLEAEVESYHSRLAAAIHDR--DQSETSKRELE----LAFQRARDECSRLQDKMNFD
VSNLKDNNEILS--------------------------Q-QLFKTESKLNS--LEIEFHH
TR-DALREKTLG-LER--VQKDL--SQTQCQMKE-----MEQKYQN-EQVKV------NK
YIGKQESVEERLSQLQSENMLLRQQLDDAHNKA---DNKEKTVINIQD----QFHAIVQK
LQAES-EKQSLLLEERNKELISEC-NHLKERQYQYENEKAER EV--VVRQLQQELADT--
--LKKQ------SMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQ-LQEAQDRHTEAVR
CAEK-----------------------------------MQDHKQKLEKDNAKLKVTIKK
QMDKIEELQ----KNLLNANLSE-------------------------------------
-------------------------------DE---KE-QLKKL---TELKQSLECN-LD
QEMKKNVELEREITGFKN-----LLKMTR--------------KKLND------YENGE-
---F-SFHGDLKTSQFEMDIQINKLKHKIDDLTAELETAGSKCLHLDTK-----------
-NQVL--QEELLSMKTVQKKCEKLQKNKKKLEQEVINLRSH---IER-NMVELGQVKQY-
KQEIEERARQEI-AEKLKEVNL---FLQAQAA-SQENLEQ-LREN-NFASM KSQMELRIK
DLESEL-SKIKTSQEDF------NKTELEKYK----QLYLEELKVRKSLS-SKLTKTNER
LAEVNTKLLVEKQQ---SRSLFT------TLTTRPVMEPPCVGNLNNSLDLNRKLIPREN
LVI-STSNPRASNNS-MENYLSKMQQELEKNITRELKEA-AAE-----LES-----G---
--------------------SI-ASPLGST---------DES----NLNQDLVWKASREY
VQVLKKN--YMI------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------MKKIFNFGSRRE------------------------------
--------------------------------------------------------LSPG
RSSF----------------SPHPRR---------------------DSGSDPSPQAGYV
VKMKELGK-----IHK---------------AAAIGDV----------------------
AK---VQQLLLLGL-AS--VD-DLDKE------------------NRTPL----------
----------HLAC--ANGYPDLVSLLVERKCKLNL--HDNDCQTPLIK-----------
-AVQCQQEECATILL-EHGADPSIMDTH----HN--TALHYAA-SGHNIMITAKLLRYKI
EMEAKNKE-G---YTPFL------LAVTENNQDMVD-LFLKNGAN--------VNAS---
-DRFDX-------XX-XXXXXX--XXXX--XXXXXX------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------XXX
XXXXXXXXXXXXXHSD--KPGT--------------D----Y--SWPTMDE---------
--------EEIDFSTKK-------------------LPKSNLIKIANASQQIRK---KLD
EKSSTVNT------------------EHRAFLGHSQSESE--------------------
---------------------K-------------------EDMT---------------
------------------------------------------------------------
-----------------------------DTLPK--------------------------
----------------------------------PSSRAQSSPHSV--HPSLGSFSRFSQ
EMT---------------------------------------------------------
-----------------------------------------TLL----------------
-----------------------------------DINKXXXXXXXXXXXX---------
---XXXXXXX----XXXXX--------------XXXXXX-------------XXXXXXXX
XXX----XXXMMSALGLEEEKEAESLWDSEXX-XXXXXXXXXX---------------XX
XXXX-ERREGNLGN---V------TKD----------------------------LFNI-
PFINESRNFKIDKLMATGSI--------------GIPVGSVDYLVRHPNLKPT----IEM
-KDYFTNR-----------------------------EVERS------------------
------------------------------------------------------------
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----------------------------------------SGKS----------------
--------------------------------------------KSXXXXXX--------
------------------------------------------------------------
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------XXXXXXXXXXX-------------XXXXXXXVE--------EEKKKHQ------
---------------------------HNEMETL---EETDG------------------
-------DKLTE---------NRKIGKVN-----ELFSIE----S---------------
---------NQSDSVMQKKE-VKTSPK--DKWISEDPGINSSCEKVNAS-----------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------IDVLLRGPEDSSLSE-
-------------------ADHDEE---RPAKKIWNKKNK---IKRL---ID--------
------------------------------------------------------DV-DDL
TQSSDAATEDYDLP--PLNYKNVLLLIEQLX---XX--XXX--AIKLLKIEDA----VLR
YNRLIEH---KQRQ-------------------CSLLARKVKSLENK-------------
--ITGLQ----EELSETR---EKKSQLELQKAE-WNREL--HSIXXXXXXXXXXXXXXXX
XX-XXXXXX----XXXXXXX------------------XXXXXXXXXXXXXXXXXXXXXX
XXXXXXXX-XVEEERNDTQRQLSQELRARALQAGIQ-----NNPLCK--QKEIEVLP---
-KL-----TSE-VPDSNEKEKY---LLDK------NQILQDEVAMLQVELDTLKIKDQEK
ASQFTEENEVLKEENDELQKKLQLNEEALT--------KIISQYSGQVNVL-T------T
ENAMLNSK-----------------------------------LENAKQNR---------
--ARLETEIESYHSRLTSAVHDH--ERSQTSKLDLE----RTFQRERDEWLRLQRKLNHD
LTSLRENNAVLC--------------------------Q-KLSKAENKANS--LENELYH
VH-DSLREKTLV-LES--TQREL--SQAQHKAQE-----LEHTNQL-EKEKL------KK
YVVKYESMQERLTQIQSKNMLLQQQLEDAQNKG---HE--KVLSDAQGEFTDLFSKFVQI
LVTES-EKQVLKLQERNKELISEC-NHLREKMCKYENEKAEREA--TVRKLQQELADS--
--LKNQ------SMTETSLEVTLFDRNDFEDKKKLQKXXXXXXXXXXXXXXX-XXXXXXX
X-----------------------------------XXXXX-XXXXXXXXXXXXXXXXXX
XXXXXXXXX----XXXXXX-----------------------------------------
------------------------------XXLNNERE-KLKKL---IELKQSVENR-LE
RETKKNEELQKDLSGFKKL-----LKTTK--------------KKLRE------YEKG--
--DV-VYQGGVKQTYSEMEREISMLKNKTEDLRQQLEAEYSTCNQLKSI-----------
-NESQ--GEEPFSVKILQTKCAKLEGYKRELEEEVVNLRHH---LEI-TKLERSEIEQY-
KHEIDEQAKQRI-IEKLKEVNL---FLQTQAA-SRENLEQ-LREN-NNASIRNQMEHRIR
DLESEL-YKMKNSRQ------DSTEAEIKRYR----QLYSEELKIRKSLS-NKLDRTTER
LAEVSARLLNEKQK---NKVLIN------SFAASPVLEPSHIGNINTSMFLSRSLIPRGN
LVC-SAGNTVSSKSR-VEAYMAKMQQELEENITRELDE----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------MKRLLAAAGKG-----V-------------------------
--------------------------------------------------------RGPE
PPNP--------------FSER-----------------------------VYTEKDYGT
IYFGDLGK-----IHT---------------AASRGQV----------------------
QK---LEKMTVGKKPVN--LN-KRDMK------------------KRTAL----------
----------HWAC--VNGHAEVVTFLVDRKCQLNV--LDGEGRTPLMK-----------
-ALQCEREACANILI-DAGADLNYVDVY----GN--TALHYAV-YSENLLMVATLLSYGA
VIEVQNKA-S---LTPLL------LAIQKRSKQTVE-FLLTKNAN--------ANAF---
-NESKC-------TA-LMLAIC--EGSS--EIVGM-------------------------
--LL-QQN-VDV--------FAED------IHG-ITAER---YA-AA---CGV---NY--
--IHQQLLEHIRKLPK-N-PQNT-----NPEGTS------------------------TG
TPDEAAPLAERTPDTAESLLEKTPD-----------------------------------
------------------------------------------------------------
-------------------------------------------------------EAAR-
--------LVEGT-SA--K--I---QCLGKAT-SGKFEQSTE--ETPRK--------ILR
PTKETSE--KFSWPAKE-------------------------------------------
-----------------------RS-RKIT----------WEEKE------------T--
------------------------------------------------------------
------------------------------------------------------------
-------------------------------SVK--------------------------
---------------------------T--------------ECVA--GVTPNKTEVLEK
G-------------TSNMIACP--------------------------------------
------------------------------------------------------------
-----------------------------------TKETSTKASTNVDVSSVEPIFSLFG
-----TRTIENSQCTKVEE--DFNLATKIISKSAAQNYTCL--------PDATYQKDIKT
INH---KIEDQMFPSESKREEDEEYSWDSGSL-FESSA----------------------
----------KTQVCI-----------------------PESMYQKVMEINREVE-----
------------------------------------ELPEKP-----SAFKPA----VEM
-QKTVPNK-----------------------------AFELKNEQ--TLRAAQM---F--
PSE-SKQKDDEENSWDSESPCETVSQK---------------------------------
------------------------------------DVYLPKATHQK--EF---------
---DT---LSGKLEESPVKDGLLKPTCGRKV----------SLPNKALELK---------
------------------------------------------------------------
------------------------------------------------------------
-----------------DRETFK-------------------------------------
------------------------------------------------------------
-----AESPDKD------------------------------------------------
--------------------------------------------------------G---
-L---------L-------KPTCGRKV-SL-PNK-ALELKDRETL-----KAE---SPDN
DGLLKPT---------------CGRKVSLPNKALELKDRETFKAAQ----MFPSESKQK-
---------------------DDEEN------SWD------------F---E---SFLET
LL---------------------------------------------------------Q
NDVCLPKATHQ-------------------------------------------------
----------KEFDTLSGKL----------------------------------------
------------------------------------------------------------
-------EESPDKDGL-----------LKPTCGMKISLPNKALEL-KDR-----------
-ETFKAEDVSSVES-TFSLFGKPTTENSQSTKVEEDFNLTTKEGATKTVTGQQERDIGII
E---------------RAPQDQTNKMPT--SELGRKEDTK--STSDSEIISV--------
------SDTQNYECLPEATYQKEIKTTNGKIE----------------------------
------------------------------------------------------------
----------------------------------ESPEKPSHFEPATEM-----------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------QN-SVP-NKGLEWKNKQTLRA-
-----------------------------D------------------------------
------------------------------------------------------------
-------------------------------------------STTLSKILDA----LPS
CERGREL---KKDN-------------------CEQITAKMEQTKNK-------------
--FCVLQ----KELSEAK---EIKSQLENQKAK-WEQEL--CSVRLTLNQEEEKRRNVDI
LK-EKIRPEEQ--L-------------------------RKKLEVKQQLEQTLRIQDIEL
KSVTSNL-----------------------------------------------------
---------NQ-VSHTHESEND---LFHE------NCMLKKEIAMLKLEVATLKHQHQVK
ENKYFEDIKILQEKNAELQMTLKLKQKTVT--------KRASQYREQLKVL-T------A
ENTMLTSK-----------------------------------LK-EKQDK---------
--EILETEIESHHPRLASALQDH--DQSVTSRKNQE----LAFHSAGDAPL--QGIMNVD
VSNTIYNNEVLH--------------------------Q-PLYEAQRKSKS--PKINLNY
AG-DDLRENALV-SEH--AQRDR--CETQCQMKK-----AEHMYQN-EQDNV------DK
HTEQQESLEQKLFQLESKNRWLRQQLVYAHKKV----NKSKVTINIQF----PE------
----M-KMQRHLNEK-NEEVFNYG-NHLKERIDQYEKEKAEREV--SIKKYKYFSN-F--
--LK---------ESGLG------------------------------------------
------------------------------------------------------------
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-----------------------------

------------------------------------------------------------
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------------------------------------------------------------
-----------------------------------------------TPL----------
----------HLAC--VLGSINTVQLLVENKCLLNP--RDQFKRTPLFK-----------
-AVQCKYVVCSQFLL-EHGADPNLVDIH----GF--SVLHYAV-YDNSPFLAELLIF--A
NIEAKDKV----------------------------------------------------
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-----------------------------

------------------MNKLFSFWKRKN------------------------------
--------------------------------------------------------ETR-
-------------------------------------------------------SQGYN
LREKDLKK-----LHR---------------AASVGDL----------------------
KK---LKEYLQLKK-YD--VN-MQDKK------------------YRTPL----------
----------HLAC--ANGHRDVVLFLIEQQCKINI--RDSENKSPLIK-----------
-AVQCQNEDCATILL-NCGADPNLRDVR----YN--TALHYAV-CGQSFSLVEQLLDYEA
DLEAKNKD-G---YTPLL------VAVINNNPKMVK-FLLEKGAD--------VNAS---
-DNYQR-------TA-LILAVS--GEPT--RLVKL-------------------------
--LL-QQG---------------------------LRNM---LI-SM---VLL---YI--
--HNSLQVMERRNMLN--RHLIL-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------G--------------
----------TA--CD--------------------------------------------
------------------------------------------------------------
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-----------------------------

------------------MKKLFHFRKKTQPEACVP------------------------
---------------------------------------------------------IP-
------------------ARR-------DVG------------------VSGESAEEAYR
IRKKDVGK-----LHQ---------------AASTGDC----------------------
PE---VQWLLLVK-GKD--IN-ELDQF------------------NRTAL----------
----------HLAC--AAGYPDVVSLLVERHCKLDV--CDSNHRTPLMK-----------
-AVQCQQEECVSILL-LHGADPNMVDES----SS--SALHYAA-SGYSTAIAVKLLEWKA
DIEAKDGH-G---FTPLL------LAVKNHHEEMVD-LFLKNGAN--------VNGC---
-DDCRR-------TA-LMIALS--SNSTPTSLIKL-------------------------
--IL-QYD-VDL--------SCQD------YFG-RTIKD---YP-YS---SHA---KV--
Y----WIMKAPGSLTYLMQDSMLSCRPACSAS------------------------LTF-
CTNSFS----------------SM------PEYSVPRVSGDFKWT------N--------
--------WGSVVSR-HRELVLQ-YVKS----------KLNE--------PCV-------
----------AEIS------------------SPDVTSDISFTSGGPVLDKKV-------
-AEQNSPEVSRSRFSD--K--------------PGLD---D---SWSSSDE-----EL--
-----------DFSIQN-------------------PPKLNLKKLITAT--PQ-------
------I------RRIKDEKSSTVKTELRTCLSHNQTDNEKEDVT----------DSL--
------------------------------------------------------------
------------------------------------------------------------
-------------------------------L----------------------------
---------------------------------HPSSQAQYSLHPA--HLSPGTFSMPVQ
KLSAPV---DSNKRVSENLPKGS-------------------------------------
------------------------------------------------------------
-----------------------------------TRQKSAATTPTMKEVFSSGQLEDYT
EKYHKLQFTQ----PTLEIKDSFTNQETKK------------------------GIKKKE
KSDPGH----RV-VRNPGV----SPKRW--------------------------------
------------------------------------------------------------
----------------------------------GFSKAEV----------------SPI
-TLSLPLD-----------------------------AVALGHKQWLRPALSSRASPS--
TSL----------------------K----------------------------------
--------------------S--------VTSRTSKHVHFDVVEES-SSEVSISRFSDKP
GPDDSWSTSDEELDFSIQKPPDLNLKKLINASQQIRRIIDEKSSSVNTELRIFLGHNHSD
NETDVTDSLPQPSSQIQYSLNPVHPSPGTFSMSVRK-----------VSAPMD---INKE
ELMDT---EEEPKNDGMLMVNNATREQRHDET---PNSPSELGAH--SMSQKCAVRKDL-
------------------MSAFT-------------------------------------
-----------------------------GG-EEEDAESP--------------------
--WDS--ETASESL----------------------------------------------
---PKGSMRHISAITNQI------IKESISGG----QLE--G------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-----------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------SFLKQPTLRATRDKKTSVL-VKVREI------NDGKKSWT---
-VSS--------------------------------QKQL--------------------
----------DL--------KATS-------D----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------KKDSVSNI----------------------------------------------
---------ATEIKDGP-KPGTVSSQK---------------QLALKATSD---K-----
------------------------------------------------------------
-----------------------------------------KDSVSNIATEIKDGPKSGI
VSSV--------------------------------------------------------
-------------------------------------------KQPALRATSDRKKSVSA
VAREIKDGDKSGTVSSQKQRAAKAPRDKKDPVSNIGTEIKDGSKSG--AVSPEQPP----
---L--------------------------------------------------------
------------------------------------------------------------
--------------------------------FMH-------------------------
------------------------------------------------------------
TVK----DKDHISTRVVGK--LDSPTSREVSS-QKQPTLKAATDKK-----------DSV
SNIA-----TEIKD------------------------------------E---QK----
------------------------------------------------------------
-------------------------------------------SG-----TDSSQKQQ--
-----TL----------------------------------KAI--SVKTDSVSN-----
---------------------------------------ITTEIK----------DGKK-
-P----------------------------------------------------------
------------------------------------------------------------
---------RTVSSQKQSAWKALFK-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------RK-------------------------------------------------
------------------------------------------------------------
-------------------------------------------VSLSNI-----------
-----------------------------------ATGI-A--D----------------
--------------------------------GQKSGAESSQKQLALK--TT---SDKKD
SVSN-----------IATETKDVQKS----G-----------TVY---------------
---------------------------AQKQLA---------------------------
--------------LK--------------------------------------------
------------------------------------------------------------
-----------------------------ATIDKKDSVSNIATEI-KDGK----------
--KSKTVSSQKQ------------------------------------------------
------------------------------------------PAWKAIIKKKVSLSNIAT
G-----------------------------------------------------------
-----------------I--------T-VVEKSGAEYPENL-------------------
-------------PTLKVT-----------------------------------------
------------------------------------------------------------
-----------------------------------IE--NKDSVLNIATEMKDVHTSLPA
-------------------------------------------E----------------
--------------QDLEMASEGE---QKRFEEYENNQPW--------------------
---------------------------------------------MKNQIHFRDDL-DDV
IQPSQIASEGDDSL--SS--KKVILLIDQHG---MQ--CK--DCAHLLKIKNA----IYL
HERSIEN------H-------------------CERLTGKIQKMKNK-------------
--ISILQ----KRLSEEK---EIISQLEHEKPE-WEKAL--CSLRYAILQEKEKGRNSEK
LH-EKVREK----II-MEEQ------------------HAIDAKEIKQLKLAIKSLEVEL
ETVENDSN----------------------------------------------------
----------Q-ISDSHGKEED---LLHK------NHLMQDEIARLRLEVDTIKNQN--L
EKKYLKDIEIIKGRNEDLQKTLKWNGETLT--------KMIARSSGRLTAL--T-----D
ENTMLRSK-----------------------------------LEKEKESN---------
--QRLETEIESYRCRLNAVLRDH--DQNQSSERDQE----LAFQGTVDKWCHLQENLNSH
-------VLILS--------------------------Q-QLAKAESKSSG--LETELCY
TR-EALKEKTLV-FEC--MQRDL--NQTQCQMKD-----IEKMYKN-GQDKV------EK
CIEKQE----RLCQLHRQSMLLQQQLNDAHNKA---DNQEKTLINIQA----KCDARVQN
VQAEC-RKRSILLEEENKRLINEV-NHLKEKQCQYERDKAEREV--LIRQLQQKRDDA--
--LHKE------STSKTLVDASLRRSIHLESELEDSKKKAGQMRSQ-FQEIQDQLTATLR
RAEK-----------------------------------MQGHIQKLEIENSMIRNIIKN
QDDQIEQLQ----KIMQNSTLRQQV-----------------------------------
--------------------------------L---QE----------NEK---------
------------------------------------------------------------
------------------------------------------------------------
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-----------------------------

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------------MRPRKKKLEE------------------DDKG--D-------------
--LASQ------EALK----Q-ACS--QVEDA-----QMNT-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------LRNQKEELAQQVEAASSKCIQLEWT-----------
-IQGL--RQELLSKESLEEKNGKLEKEKSQLEEEIANLKHR---FKM-TMLEHRQVEQY-
KSEVDEQATQEI-IGKLRTIKL---FLQTQAA-FQNNTEQ-LGEN-HQAPRGNEMEWRMK
YMEAEL-STLRSSYQDA------E-EQLERNT----QLYFKELKANESLS-KELDRANRR
LLKVSAKLRNERQR---NETLRA------SFTASPVLGPPPTEPPNSSSLFNGGLIPRGN
RTC-FEQ-----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

MVV-----EVDSMPAASSVKKPFGLRSKMGKWC---------------------------
----------CRCFPCCRESGKSNVGTSGDHDDSAMKTLRSKMGKWCRHCFPCCRGSGKS
NVGASGDHDDSAMKTLRNKMGKW-CCHCFPCCRGSSKSKVGAWGDYDD---SAFMEPRYH
VRGEDLDK-----LHR---------------AAWWGKV----------------------
PR---KDLIVMLRD-TD--VN-KQDKQK------------------RTAL----------
----------HLAS--ANGNSEVVKLLLDRRCQLNV--LDNKKRTALIK-----------
-AVQCQEDECALMLL-EHGTDPNIPDEY----GN--TTLHYAI-YNEDKLMAKALLLYGA
DIESKNKH-G---LTPLL------LGVHEQKQQVVK-FLIKKKAN--------LNAL---
-DRYGR-------TA-LILAVC--CGS-A-SIVSL-------------------------
--LL-EQN-IDV--------SSQD------LSG-QTARE---YA-VS---SHH---HV--
--ICQLLSDYKEKQMLKISSEN--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------SNPEQ-----------
---------DLKLTSEE------------------ESQ------------RFK-------
--------------------------------GSENS-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------QPE--------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------KMSQEPEINK-----------
---DGDREVE--------------------------------------------------
---------EEMKKHE--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----SNN------------------------------VGLL------------------
------------------------------------------------------------
-----------------------------------------E-------NL---------
--------------------------------------------------TNG-------
------------------------------------VTA---------------------
---G---------NG---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------D-NGLI---------------------------P----
----Q-------------------------------------------------RKSRTP
----------------------------------------ENQ-----------------
--QFPDNE------------------------------------------------SE--
------------------E-----------------------------------------
----------------------------------------------------YH------
-RICELLSDYK-------------------------------------------------
------------------------------------------------------------
-----------------------------E------------------------------
-------KQMPKYSS---------------------------------------------
------------------------------------------------------------
-------------------------------ENSNPEQD---LKLTSEEESQRL------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------KGSEN-GQPEKRSQE------------------------
---------------------------------------------------------PEI
------------NKDGDRELENFMAIEE-M-----K--KHR--STHVG------------
-------------F-------------------PENLTNGATAGNGD-------------
--DGLIP----PRKSRTP---ESQ-----QFPD-TENEE--Y-HS---------------
------------------------------------------------------------
------------DEQNDTQKQFCEEQNTGILHDEIL-----IH---E--EKQIEVVE---
-K-MNSELSLS-----CKKEKD---ILHE------NSTLREEIAMLRLELDTMKHQSQLR
EKKYLEDIESVKKRNDNLLKALQLNELT MD--------DDTAVLVIDNGSGMCKAGFAGD
DAPRAVFP-----------------------------------SIVGRPRQQGMMGGMHQ
KESYVGKEAQSKRGI-------------LTLKYPMEHGIITNWDDMEKIWHHT-------
----------------FYNELRVAPEEHPVLLT-----EATLNPKANREKM---------
-------------------------TQIMFETFN-----TPAMYVA-IQAVL------SL
YTSGR---------------------------------TTGIVMDSGD----GVTHTVPI
YEGNALPHATLRLDLAGRELPDYLMKILTEHGYRFTT-MAEREI---VRDIKEKLCYVAL
DFEQEMATVASSSSLEKSYELPDGQVITIGNERFRCPEALFQPCF----------LGMES
CGIHETTFNSIMKSDVDI-RKDLYTNTVL-SGGTT---MYPGMAHRMQKEIAA-------
-------LA----PSMMKI--------------RIIAPPKRKYSV---WVGGSILASLST
FQQMWISKQEYDE-----------------------SG-------------PS-------
------------------------------------------------------------
-------------------------------------IVHRKCL----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------MRKLFSCGRRLG------------------------------
--------------------------------------------------------RAVL
GS----------------------------------------------ID-HQSAGPGCH
TRDAELRK-----IHR---------------AAIQGDA----------------------
AE---VER-LARRS-RD--VD-AQ---------------------DRTVL----------
----------HLAC--ARGRVEVVTLLLSRKCQINI--CDRLNRMPLMK-----------
-AVYCQEETCSIILL-EQGANPNIKYVY----SN--TALHDGK-C---------------
------------------------------------------------------------
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-----------------------------

------------------MIKFWGYIKKKA------------------------------
--------------------------------------------------------QLSS
SPFD--------------PSERSNSI-----KG----------TGSSSNVLTTQNAPGYC
IRYKDLGK-----LHK---------------AAFLGDL----------------------
AK---VQHHLLFKK-QD--LN-KRDKE------------------HRTPL----------
----------HLAC--ANGYPDVVSLLVEKKCKLNI--CDSENRSPLIK-----------
-AVQCQQIECATILL-ENKAEPNLGDIH----KN--TALHYAA-CGHNISLVNKLIEHKA
NIEAQNKD-G---HTPLL------LAITENNPEMVA-ILLKRGAD--------VNAS---
-DKLQR-------TA-LMLAVG--GEPI--GIVNL-------------------------
--LL-QYD-VDL--------SCQD------IYG-LTAEE---YA-TC---SGY---SI--
--HHELISQYKIQKNL--KKSIF-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------P--------------
----------GM--SH--S-------------------------ERISAIKF--------
-----------S------------------------------------------------
------------------------------------------------------------
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-----------------------------

MVA-----EVGSMPAASSVKKPFGFRRKMGKWG---------------------------
----------CHCLPCCRGSGKSNLGASADQDDSARKTRRSKMAKWCCHCLPCCRGSRKS
NWALLE-TRMTRLKTLRSKMAKW-CCHCLPCRRGSGKSNLGAWEEYDD---SAFVEPRYH
VRREDLDK-----LHR---------------AAWWGKV----------------------
PR---KDLIVMLRD-TD--VN-KTDKQK------------------RTAL----------
----------HLAS--ANGNSEVVKLLLDRQCQLNV--LDNKNRTALTK-----------
-AVQCQEDECALMLL-EHGTDPNIPDEY----GN--TALHYAI-YNEDKLMAKALLLHGA
AIESKNK-----------------------------------------------------
------------------------------------------------------------
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-----------------------------

------------------MKRFFPFRGKRK------------------------------
--------------------------------------------------------TDDS
-------------------YSHSSEL-----SI----------SMTSTAPPSLSTGRGYH
LRDKHSKK-----LHK---------------ATVVGNV----------------------
QK---LKDYLERKK-YN--VN-GRDKR------------------SRTPL----------
----------HLAC--ANGYTNIVCLLIENQCKINV--QDSENRTPLIK-----------
-AVECQQESCAMILL-LHGADPNLVDVY----SN--TALHYAV-CGQNISLANKLLEYKA
NLESKNKD-G---HTPLL------LAVAENNENMVK-FLLKKGAD--------VNAS---
-DKNHR-------TA-IMIALI--VEPT--SSVKL-------------------------
--LL-QQD-TDL--------AHKD------IYG-FTAEE---YA-FF---NGF---TT--
--YHQITANNENKKKT--ERTAY-------------------------------------
------------------------------------------------------------
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-----------------------------

------------------------------------------------------------
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------------------------------------------------------------
IRDKDLRK-----IHK---------------AAIVGNV----------------------
AK---AALHLSKND-FK--ST-NRNVA------------------QRTAL----------
----------HLAC--ANVHSVVVTLLLERKCLLNL--CDNENRTTLMK-----------
-AIACQEDECATLLL-EHGADPNAMDVC----GN--TALHFAV-FCQNISLAAKLLSCDA
NIEARNKD-G---LTPLL------LAICERRGQMVE-FLVKKEAN--------IHEV---
-NKMKR-------TA-LMLAVK--YEST--NVVRL-------------------------
--LL-QQG-ADI--------FSQD------IFG-WIAEK---YA-VI---S---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------G--------------
----------F-------------------------------------------------
------------------------------------------------------------
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-----------------------------

------------------MRKLLSFGRRLG------------------------------
--------------------------------------------------------QALL
SS----------------------------------------------MD-QEYAGRGYH
IRDWELRK-----IHR---------------AAIKGDA----------------------
AE---VEHCLTRRF-RD--LD-VRDRK------------------DRTVL----------
----------HLAC--AHGRVQVVTLLLDRKCQINI--CDRLNRTPLMK-----------
-AVHCQEEACAIILL-KRGANPNIKDIY----GN--TALHYAV-YNEGTSLAERLLSHHA
NIEALNKE-G---NTPLL------FAINSRRQHMVE-FLLKNQAN--------IHAV---
-DNFKR-------TA-LILAVQ--HNLS--SIVTL-------------------------
--LL-QQN-IHI--------SSQD------MFG-QTAED---YA-FC---CDL---RS--
--IQQQILEHKNKMLKNHLRNDN-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------Q--------------
----------E----T--A-----------------------------------------
-------------------------------------------AM-------K-------
-----------------------------PEN----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------L-
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------KKRKK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------R
------------------------------------------------------------
----------------------------KK-------LKKRKEGA---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------KAEHNLKVASEEKQERLER--SENKQPQDS---------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------QSYGKKKD---EMFG------NFMLKRDIAMLKEELYAIKNDSLRK
EKKYIQEIKSITEINANFEKSVRLNEEMIT--------KKVAQYSQQLNDL-K------A
ENARLNSK-----------------------------------LEKEKHNK---------
--ERLEAEVESLHSNLATAINEY--NEILER-KDLE----LVLWRADDVSR--HETMGSN
ISQLTDKNELLT--------------------------E-QVHKARVKFNT--LKGKLRE
TR-DALREKTLA-LES--VQLDL--KQAQHRIKE-----MKQMHPN-GEAKE------SQ
SIGKQNSSEERIRQRELENLLLERQ-LEDARKE---GDNKEIVINIHR----DCL-----
---EN-GKEDLL-EERNKELMNEY-NYLKEKLLQYEKEKAER EV--IVREFQEELVDH--
--LKKF------SMSESPLEGTSHCHINLDE-TWTSKKKLFQVEIQ-PEEKHEEFR----
------------------------------------------------------------
-------------K----------------------------------------------
-------------------------------------------V---FELISLLNYT-AD
QIRKKNRELEEEATGYKKC-----LEMTI--------------NMLNA------FANE--
--DF-SCHGDLNTDQLKMDILFKKLKQKFDDLMAEKEAVSSKCVNLAKD-----------
-NEVL--HQELLSMGKVQEKCEKLEKDKKMLEEKVLNLKTH---MEK-DMVELGKVQEY-
KSELDERAMQAI-EKLEEI------HLQKQAE-YEKQLEQ-LNKD-NTASL-K KKELTLK
DVECKF-SKMKTAYED-----V--TTELEEYK----EAFAVALKANSSMS-EKITKSDKK
IAVISTKLFMEKER---MEYFLS------TLPMRPDPELPCVENLNSIE-LNRKYIPKMA
IRI-PTSNPQTSNNC--KNSLTELLLRWALAPIYFLL-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

MPEDIDY-------DAQTPN--A------S------------------------------
---------------------------------------------------------EQP
HWYW--------------RL--WTCCLGYGC--------------LD--YQ-VDEYPAYL
IPYEPVGQ-----FQR---------------AASMGDL----------------------
ST---VEHFITSG-RYH--VD-KCDRR------------------NRTSL----------
----------HYAC--AHNHPEVVTLLIESNCNINV--QDDEGCTPLIK-----------
-ATERNNLECVSILL-KHGADPHTADFT----GN--TALHYAV-YNGNKAIASELLEYKV
DINTTTKH-G---FTPFS------LAVFEKQEKMVE-FL---------------------
------------------------------------------------------------
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-----------------------------

MGA-----EVSSKPAASTMKKPFGLSGK--------------------------------
------------------------------------------------------------
-------------------MGKW-CCHCFPSCRGSGKNHVDSRGDHDD---IACL-----
------------------------------------------------------------
--------------------------EP------------------RTAL----------
----------HLAC----GNSEVGKLLLDRKCQLRV--FDSKKRTALTQ-----------
-AVRC-----AILLL-QHGIDPNLPDVY----GN--TALHYAV-YSEDRLMAKTLLLYNA
DIESKNKG-G---LTPLL------LGVHGQKQQMVE-FLIKKKAN--------LNAL---
-DRFGR-------TA-LILAVR--CGS-A-SMVSL-------------------------
--LL-QQN-IDV--------FSQD------VSG-WTAED---YA-IS---SHH---NI--
--ICQLLSDYKEKQMPKKCSEN--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------SNPEQ-----------
---------DLKLTSEE------------------EPQ------------RLK-------
--------------------------------GGENS-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------QHE--------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------KMSQEPDVNK-----------
---DCDREAE--------------------------------------------------
---------EEMQRHG--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----SNN------------------------------VGIS------------------
------------------------------------------------------------
-----------------------------------------V-------NL---------
--------------------------------------------------TDG-------
------------------------------------AAA---------------------
---G---------NG---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------D-DGLI---------------------------P----
----Q-------------------------------------------------RKSRKP
----------------------------------------ENQ-----------------
--EFPSTE------------------------------------------------NE--
------------------E-----------------------------------------
----------------------------------------------------YH------
-RPEKKFNEKN-------------------------------------------------
------------------------------------------------------------
-----------------------------K------------------------------
-------VKSEIHSV---------------------------------------------
------------------------------------------------------------
-------------------------------DDL---DD---IMWPSEIASEDY------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------DL
------------LY---PNYETFMLLAEQLK---MD--FNG--RTIA-------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
-----------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TAL----------
----------HLAC--ANGHPEVVALLVDRGCQLNV--FDNKNRTALLK-----------
-AVQCQEEECATILL-ELGADPNPPDVY----GN--TALHYAI-YNEDIPMTKKLLLHHA
DIESANKV----------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------KVQMD-TG--------
------------------------------------------------------DL-DDF
TQSSDTVTEDYDLS--PSNYKNVMLLIEHLS---VD--CK--DSVHLLKIQDA----VLT
YERSVEL---KKAQ-------------------CSELERKVKTLEKK-------------
--ITGLQ----EKLSETR---KVKSQFEHQKVE-WDREL--YRVRFTLKQEKEKQSSIEM
LF-EKTKEQ----LRKREEQ------------------YNKEVHLKQQLEFKLRTLDREL
TSVRNNFK-QQKEIEAATSKMIQSSEK-HILPKTYI-----YIYIYI--YIYISVDN---
-CISSAPNRKL-AMANQEKEKR---LLCE------NQSLQDEVVRLKLELETLKIKTQEK
ENRYVEENEILKKNNDELRKELKLNEN---------------------------------
--AILNSG-----------------------------------LEDEKQNR---------
--DKLEKEIKSYHARLNSAILDH--ERSQTSKLDLE----HNFQRERDEWLHVQAKLN--
-----DNYGVVS--------------------------Q-ELSKAESKVNR--LENELCQ
LR-DSLREKTVI-IES--VQREL--KQAQYKATE-----LKHKNQM-DNEKL------DR
YIVKQESIQERLAQIQSENILLRKQLEDAQNKD---VIEEDVLNTVQV----QFRDFFNQ
LHADN-EKHVVVVEERNKELINEC-NHLREQMCKYENEKAERED--IIKQLQQELADS--
--LKKQ------SMTEASLEATSHFQNNLEDNR-KLQKEVNHIKSK-VCMQKISNLLLIK
N--Y-----------------------------------FYHFFYHLKL-----------
------------------------------------------------------------
---------------------------------SPSK--HIFSL---ITVIRGISSERTE
QEQCSL---------------------------------------------------GK-
---L-HEQ---KHSS---MRSVVVKKIRCSHLNECLELGLNQCSHLND------------
------------EKKYLQNKYDNLEKNNRELEELVLYLKHN---LEI-SKLEHSQIEQF-
KQEIKEEAKQEI-IEKILKVIF---FQNYTCL-YNLIYIS-TREQ-AASQEKNQMECRIQ
ELEAEI-SKMKNSHQTY-------KAALESYK----KSYREELKIKA-SS-NKLDRTNER
LAELSSRP--QTQK---SKTLAN------SFTVCPVQEMPLIGNLHSPSVLNRSFIPRGD
LGY-PMGNTVSSPHS-IESYLTKMRRELEKNITRELHSD-NAG-----LES-----G---
--------------------PCWASPIVPT---------HQPTGTPNVNQDPLSRAKQEY
LEVLNKK--YML------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------MKRIF---SKKG------------------------------
--------------------------------------------------------ESPL
GSFA----------------LRRRSNSGGGG----------------EPGDGPYSQPGYH
VRDRDLGK-----IHK---------------AASAGNV----------------------
AK---VQQILLLRK-NG--LN-DRDKM------------------NRTAL----------
----------HLAC--ASGHPEVVTLLVDRKCQLNV--CDNENRTALMK-----------
-AVQCQEEECATILL-EHGADPNLVDVH----GN--TALHYAV-YNEDMSVATKLLLHDA
NIEARNKD-D---LTPLL------LAVSGKKQHMVE-FLIKKKAN--------ANGV---
-DKLKS-------SH-HLISEC--KEER--LPKNSSQNSDSADESSED------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------SLSRLSG--KPGI--------------D----D--SWPTSDD---------
--------EDVNFDTKN-------------------VPKPSLAKLMTASQQSKK---SLE
ATDGIVRT------------------GNRTSFEDRDSDSQ--------------------
---------------------D-------------------EVVI---------------
------------------------------------------------------------
-----------------------------ESLPT--------------------------
----------------------------------TSVKVHGFSHPT--YPSPDPLL-KSS
HKS---------------------------------------------------------
----------------------------------------LANP----------------
-----------------------------------GLTKEGAMKPAAGKKE---------
---NGADIIE----SPPLE--------------QTDNDN-------------LTYVDEVP
QNN------NMMSALGLGQEEDIESPWDSESI-SENFPQKYVD---------------PL
AGAADRKEKNVGNE---Q------AEG----------------------------MFYIP
SCMSGSRNFKMAKLEDTRHV--------------GMPVTHMGMEKNEYFC----------
------------------------------------------------------------
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-----------------------------

------------------MNKLFSYWKWRN------------------------------
--------------------------------------------------------ETR-
-------------------------------------------------------SQGYE
LLDKDVKK-----LHR---------------AASLGDL----------------------
KK---LKKYIQVKK-YD--VN-SQDED------------------YRTPL----------
----------HLAC--ANGHTNVVLFLIEQKCKINV--QDSENKSPLIV-----------
-AVQCQKEDCANILL-NCGADPNLMDFC----YN--TALHYAV-CGQSFSLVEKLLEHKA
DLEAKNKD-G---YTPLL------LAVIKSNPKMLK-FLLDKGAN--------VNAT---
-DNYQR-------TA-LIIALS--GGTT--CVQRR-------------------------
--LL-QQG-VEL--------SCED------VMDSQLRNM---LF-SM---VLL---YT--
--HNQWQVMERRKMLS--RHLIL-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------G--------------
----------TT--CD--------------------------------------------
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-----------------------------

------------------------------------------------------------
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------------------------------------------------------------
-----------------------KGRP------------------VRTVL----------
----------HLAC--ANGRSAVVTFLLERKCLLNL--CDNEKKTALMR-----------
-AVACQEEECATLLL-ERGANPNVMDIC----GN--TALHYAVFFGQNLSLTAKLLSYNA
YIEARNKD-D---LIPLL------LAIHERRGQMVE-FLVKKEAN--------IHAV---
-DKMKR-------TA-LMLAVK--YESP--NVVRH-------------------------
--LL-QQG-VDI--------FFQD------VFG-WIAEE---YA-II---G---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------G--------------
----------FN--EI--Q-------------------------KQITVLR---------
------------------------------------------------------------
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-----NTV-------------------------------------------LE-------
------------------------------------------------------------
-------------------------------------------------YY--R------
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-----------------------------

------------------MRRLFSFGRRLG------------------------------
--------------------------------------------------------QMLL
SS----------------------------------------------RD-EEYAGRGYH
TLDWELRK-----IHR---------------AAIKGDA----------------------
AE---VERCLKRRF-WD--VD-ARDRK------------------DRTVL----------
----------HFAC--VHGHIEVVTLLLRRRCQIDI--YDRLNRAPLMK-----------
-AVHCQDEACAIILL-ERGANPNIKDIY----GN--TALHYAV-YNKGTSLAEKLLSHHA
NIEALNEV----------------------------------------------------
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-----------------------------

-------------------MKLFASWRR--------------------------------
--------------------------------------------------------KVEP
-------------------HSPPAGW---------------------AS-THHPTQPGYN
LQDKDLKK-----LYK---------------AASVGHL----------------------
EK---VKEHLQLKK-HD--VN-VRDRE------------------YRTPL----------
----------HLAC--ANGYSNIVSLLIEQLRKINV--CDSENRSPLTK-----------
-AVQCAKEDCATILL-GHGADPNLADLD----GN--TALHCAV-CGQSVSLVEKLLEHKA
NLEDQNKD-G---YTPLL------LAITENNAKMVE-YLLKRGAD--------VNAS---
-DNNQR-------TA-LMIALS--DEPT--NLVGL-------------------------
---L-QQE-VDL--------SCQD------IYG-FTAEE---YA-SF---NGL---TV--
--YHPLIATYGRGKNV--EQISN-------------------------------------
------------------------------------------------------------
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-----------------------------

MVA-----EVSSIPAASAVKKPFGLRSKMGKWC---------------------------
----------CHCFPCCRGSGKSNVGTSGDQDDSAMKTLRSKMAKWCHHCFPCCRGSGES
NVGPSGDQDDSAMKTHRSKMAKW-CCHCFPRCKGNGESNVEAWEDYDD---SAFMEPRYH
VRGEDLDK-----LHR---------------AAWWGKV----------------------
PR---KDLIVMLRD-TD--VN-KTDKQK------------------RTAL----------
----------HLAS--ANGNSEIVKLLLDRRCQLDV--LDNKKRTALIK-----------
-AVQCQEDECALMLL-EHGTDPNIPDEY----GN--TALHYAI-YNEDKLMAKALLLYGA
DIESKNKH-G---LTPLL------LGVRGQKQLVVK-FLIKKKAN--------LNAR---
-DRCGR-------NA-LILAVR--CGS-A-SIVSL-------------------------
--LL-EQN-INV--------SSKD------LSG-QMARD---YA-VS---SHH---NV--
--ICQLLSDYKEKQMLTISSEN--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------SNPEQ-----------
---------DLKLTSEE------------------ESQ------------RLK-------
--------------------------------GSENS-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------QPE--------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------EISQEQEINK-----------
---DCDREVE--------------------------------------------------
---------EVMKKHG--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----SNH------------------------------VRLP------------------
------------------------------------------------------------
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----------------------------------ENLTNDATAGNGD-------------
--DGLNP----QSKSRTP---ESQ-----QFPD-TENEE--Y-HS---------------
------------------------------------------------------------
------------DEQNDTQKQVLEEQIAGMSQEEIL-----TN---K--QEQMEVAE---
-KEMNSEVSLS-----HKKEKD---LLHE------NCMLQEEIAMLKLEVDKIKQQSQLR
EKKLLEEIESVKAKNDKLLKAVKLREETIT--------KINI------------------
------------------------------------------------------------
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-----------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------MTKRKKTIN--LN-IQDAQ------------------KRTAL----------
----------HWAC--VNGHEEVVTFLVDRKCQLDV--LDGEHRTPLMK-----------
-ALQCHQEACANILI-DSGADINLVDVY----GN--TALHYAV-YSEILSVVAKLLSHGA
VIEVHNKA-S---LTPLL------LSITKRSEQIVE-FLLIKNAN--------ANAV---
-NKYKC-------TA-LMLAVC--HGSS--EIVGM-------------------------
--LL-QQN-VDV--------FAAD------ICG-VTAEH---YA-VT---CGF---HH--
--IHEQIMEYIRKLSK-N-HQNT-----NPEGTS------------------------AG
TPDEAAPLAERTPDTAESLVEKTPD-EAAPLVERTPDT----------------------
-----------------------------------------------------AESLV--
--------------------------------------------EKT------PDEAAS-
--------LVEGT-SD--K--I---QCLEKAT-SGKFEQSAE--ETPRE--------ITS
PAKETSE--KFTWPAKG------------------RPRKIAWEKKEDTPREIM-------
------SPAKETSEKF-TWAAKGRP-RKIA----------WEKKE------------T--
------------------------------------------------------------
------------------------------------------------------------
-------------------------------PVK--------------------------
---------------------------T--------------GCVA--RVTSNKTKVLEK
G-------------RSKMIACP--------------------------------------
------------------------------------------------------------
-----------------------------------TKESSTKASAN--------------
------------------------------------------------------------
---------DQRFPSESKQEEDEEYSCDSRSL-FESSA----------------------
----------KIQVCI-----------------------PESIYQKVMEINREVE-----
------------------------------------EPPKKP-----SAFKPA----IEM
-QNSVPNK-----------------------------AFELKNEQ--TLRADPM---F--
PPE-SKQKDYEENSWDSESLCETVSQK---------------------------------
------------------------------------DVCLPKATHQK--EI---------
---DK---INGKLEESPNKDGLLKATCGMKV----------SIPTKALELKDM-------
------QTFKAEPPGKPSAFEPA---TEMQKSVPNKALE-----------------LKNE
QTLR--------------------------------------------------------
-ADEILPSE-SKQKDY--EENSWD------------------------------------
----------------------------------TESL----------------------
--CETVSQKDVCLPKAA---HQKE---------------IDKINGKLEGS-----P----
-----------------------------------------------------VKDG---
-L---------L-------KANCGMKV-SI-PTK-ALELMDMQTF-----KAE---PPEK
PSAFEPA---------------IEMQKSVPNKALELKNEQTLRADE----ILPSESKQK-
---------------------DYEES------SWD------------S---E---SLCET
VS---------------------------------------------------------Q
KDVCLPKATHQ-------------------------------------------------
----------KEIDKINGKL----------------------------------------
------------------------------------------------------------
-------EESPDNDGF-----------LKAPCRMKVSIPTKALEL-MDM-----------
-QTFKAEPPEKPSAFEPAIEMQKSVPNKAL-------EL---------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------KNEQTLRA-
-----------------------------DQMFPSES---------KQKK----------
-------------------------------------------------------V-EEN
SWDSESLRETVSQKDVCVPKATHQKEMDKIS---GK--LED--STSLSKILDT----VHS
CERAREL---QKDH-------------------CEQRTGKMEQMKKK-------------
--FCVLK----KKLSEAK---EIKSQLENQKVK-WEQEL--CSVRLTLNQEEEKRRNADI
LN-EKIREE----LGRIEEQ------------------HRKELEVKQQLEQALRIQDIEL
KSVESNL-----------------------------------------------------
---------NQ-VSHTHENENY---LLHE------NCMLKKEIAMLKLEIATLKHQYQEK
ENKYFEDIKILKEKNAELQMTLKLKEESLT--------KRASQYSGQLKVL-I------A
ENTMLTSK-----------------------------------LK-EKQDK---------
--EILEAEIESHHPRLASAVQDH--DQIVTSRKSQE----PAFHIAGDACL--QRKMNVD
VSSTIYNNEVLH--------------------------Q-PLSEAQRKSKS--LKINLNY
AG-DALRENTLV-SEH--AQRDQ--RETQCQMKE-----AEHMYQN-EQDNV------NK
HTEQQESLDQKLFQLQSKNMWLQQQLVHAHKKA---DNKSKITIDIHF----LE------
----R-KMQHHLLKEKNEEIFNYN-NHLKNRIYQYEKEKAETEN--S-------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
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-----------------------------

------------------MNKLFSFWKRKN------------------------------
--------------------------------------------------------ETRS
-----------------------------------------------RTSSDPSIGQGYN
LREKDLKK-----LHR---------------AASVGDL----------------------
KK---LKEYLQLKK-YD--VN-MQDKK------------------YRTPL----------
----------HLAC--ANGHRDVVLFLIEQQCKINI--RDSENKSPLIK-----------
-AVQCQNEDCATILL-NCGADPNLRDIR----YN--TALHYAV-CGQSFSLVEQLLDYEA
DLEAKNKD-G---YTPLL------VAVINNNPKMVK-FLLEKGAD--------VNAS---
-DNYQR-------TA-LILAVS--DEPT--RLVKL-------------------------
--LL-QQG-VEL--------SCQD------ICG-FTAEE---YA-YF---NGF---TI--
--YPQFTASHGKKKHV--K-----------------------------------------
------------------------------------------------------------
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-----------------------------

-------------------MKLLGFGSRRG------------------------------
--------------------------------------------------------QRAQ
GS----------------------------------------------ID-HVYTGSGYR
IRDSELQK-----IHR---------------AAVKGDA----------------------
AE---VERCLARRS-GD--LD-ALDKQ------------------HRTAL----------
----------HLAC--ASGRVQVVTLLVSRKCQIDI--CDKENRTPLIQ-----------
-AVHCQEEACAVILL-EHGAHPNLKDIY----GN--TALHYAV-YSESTSLAEKLLSHGA
HIEALDKD-N---NTPLL------FAIICKKEKMVE-FLLKKKAS--------THAV---
-DRLRR-------NQ-LAHFRC--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------V--FL--L-------------------------SSIFHEL---------
------------------------------------------------------------
--------------------------------------------R---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------V----------------------------------------------------
------------DSLPASD-----------------------------------------
------------------------------------------------------------
----------------------------------------------------------DK
-DLSVATK--------------------------------------------Q-------
------------------------------------------------------------
-------------------------------------------------CV--PEKVSEP
LPGPS-------------------------------------------------------
-------------HEKGNR-------------------------------------IVNV
QGE---------------------------------------------------------
------------------------------------------------------------
-------------------GPPAKHPSLKPS-T---------------------------
---------------------------------------------------EVEDPAVKG
------------------------------------------------------------
----------------------------AV-------QRKNVQTF---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------RAEQALPVASEEEQERHER--SEKKQPQVKEGNNTNKSEKIQL--PEN---
------------------------------------------------------------
------------ICDST-------------------------------------------
--------------------------------------------SS--------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------AAAGR-LTQQRKIGKMYPQQFPKK-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------L-----------------------------------------------------
-------------------------------------KE--EHDRCTLKQENEEKTNVNM
LY-KKNREE----LERKEKQ------------------YKKEVEAKQ-LEPTVQSLEMKS
KTARSTP-----------------------------------------------------
---------NR-DFHNHEEMK---GLMDE------NCILKADIAILRQEICTMKNDNLEK
ENKYLKDIKIVKETNAALEKYIKLNEEMIT--------ETAFQYQQELNDL-K------A
ENTSLNAK-----------------------------------LLKEKESK---------
--KRLEADIESYQSRLAAAISKH--SESVKTERNLK----LALERTQDVSV--QVEMSSA
ISKVKDENEFLT--------------------------E-QLSETQVKFNA--LKDKFRK
TR-DILRKKSLA-LET--VQNDL--SQTQQQIQE-----MKEMYQN-AEAKV------NN
STGKCNCVEERICHLQCENAWLVQQ-LDDVHQK---EDHKEIVTNIQR----GFI-----
---ES-GKKDLVLEEKSKKLMNEC-DHLKESLFQYEREKAEEVV--SIKEDKYFQ-TS--
--RKKI------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------MKRFFAAAVKGE------------------------------
--------------------------------------------------------TGPE
RPSF-------------------------------------------STWST---RA---
------RL-----LMI---------------TSLARAS----------------------
WK---LGEDDEAKTHMDLTHK-SSSHS------------------HRTAL----------
----------HWAC--ANGHAEVVTLLVDRKCQLDV--LDGENRTPLMK-----------
-ALQCQREACANILI-DSGADPNIVDVY----GN--TAVHYAV-YSENLSVVVKLLSCGA
DIEVKNKA-G---HTPLL------LAIKKRSEQIVE-FLLTKNAN--------ANAV---
-DNFK-------------------------------------------------------
------------------------------------------------------------
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-----------------------------

------------MSLFSIKKKVFISET--K------------------------------
---------------------------------------------------------PQT
PLGF--------------CDGPGKRIEWKDC--------------LACRCETADKYDYDL
LLYDPDNE-----FHS---------------AVCLGKV----------------------
SE---VQSLLKEK-KYN--VN-DRDGN------------------NRTAL----------
----------HFAS--CYGKAEIVNILMENDCEINA--LDNQKTTPLIK-----------
-AVQMCEENIVSLLL-EHGADPNIKDAN----GN--TALHYAV-YVGKPAIAANLLPYGA
NIEEKTKD-G---FSPLL------LALRENQLLMAE-FLIRRGAD--------INVS---
-DEQQR-------TT-LMYAVK--SDSK--RLVDL-------------------------
--LL-NLN-IDV--------FLKD------SFS-WNALR---YA-IM---GH--------
------------------------------------------------------------
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-----------------------------

------------------------------------------------------------
------------------------------------------------------------
---ASGDHDDSAMKTLRSKMGKW-CCHCFPCCRGSGKSNVDD---------SAFVEPRYH
VRREDLDK-----LHR---------------AAWWGKV----------------------
PR---KDPIVMLRD-TD--VN-KKDKQK------------------RTAL----------
----------HLAS--ANGNSEVVKLLLDRQCQLNV--LDNKKRTALIK-----------
-AVQCQEDECALILL-EHGTDPNMPDEY----GN--TTLHYAI-YNEDKLMAKTL-----
------------------------------------------------------------
------SYLCHFRTA-LILAVC--CGS-A-SIVSL-------------------------
--LL-EQN-IDV--------SSQD------LSG-QTARE---YA-VS---SHH---TV--
--ISQLLSDYKEKQMVKISSEN--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------SNPGK-----------
---------TCNKEMSQ------------------KYN------------KQI-------
--------------------------------NLLFL-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------HLQ--------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------KRSQEPEINK-----------
---DGDREIE--------------------------------------------------
---------IQFHSST--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----CGY------------------------------LFFP------------------
------------------------------------------------------------
-----------------------------------------G-------H----------
------------------------------------------------------------
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-------------------LQYFM------------------------------------
------------------------------------------------------------
-----------------------------------KIKI--S-SS---------------
------------------------------------------------------------
------------DEQNDTQKQFCEEQNTGILHDEIL-----IH---E--EKQIEVAE---
------------------------------------------------------------
------------------------------------------------------------
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-----------------------------

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MVEFLVKKEA----NIHAVDKMKRTALMLAVKYESANVIRLLLQQGADIFSQDVFGWTAE
EYAVISGFNIHCFRQLISEYKEKRSK-TSPENNNPVDES----SEE--DSSR--------
--------------RFLNKPG---------------------------------------
--------------------------IDLGPTRNGG--CY--NSFIQHV-----------
----------L---------KSKLTKLMK----ASQ------------------QSKKNI
EAKCGILRPESTTFSQ-----DNNSDSNVEDVV-ETFPKPSPWF----------------
---------------------EGICHP--------A---FPSP----------EPV----
----SKLLKSVAGLGRTKS----------------------ISESL--------------
----PQKYVDH-LPG-------------T------AG---------------------VR
GKKYIEWTS------------RR-------------------------------------
------------------------------------------------------------
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-----------------------------

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-------------------------------------MLQEEIARLRLEIDALKNWNQQK
EKNFLEDIKIAKEKNDFLQNALMLKEETFA--------TMIFQDSIQPEVL-KA------
ENKMPSFK-----------------------------------LKDKSQNQ---------
--ERLEREIESYRCRLAAALQDR--DQSQASKRDVE----CDFQRTREEWFHLKEKMNFD
MSNLKDKNELLS--------------------------E-TLSNAENKIRS--LKMKWRQ
TK-DALREKTLV-LED--VQRDL--TQSQCRRKE-----IEQMFQN-EEDKV------SK
YIQKQESLEERLSQIQNKNLLLRQQLDEAYKKA---DNQKETIINIQE----QFNAIVKN
-QAQS-EEQSLLLDQKNNNLINKC-NFIKKRSYKYEKEKAERNV--SIEKEN--------
------------------------------------IFQTS-------------------
------------------------------------------------------------
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-----------------------------

-----------------------MED----------------------------------
--------------------------------------------------------GKRE
RWPT--------------LME----R---LC-------------------SDGFAFPQYP
IKPYHLKR-----IHR---------------AVLHGNL----------------------
EK---LKY-LLLT-YYD--AN-KRDRK------------------ERTAL----------
----------HLAC--ATGQPEMVHLLVSRRCELNL--CDREDRTPLIK-----------
-AVQLRQEACATLLL-QNGANPNITDFF----GR--TALHYAV-YNEDTSMIEKLLSHGT
NIEECSKC-E---YQPLL------FAVSRRKVKMVE-FLLKKKAN--------VNAI---
-DYLGR-------SA-LIHAVT--LGEK--DIVIL-------------------------
--LL-QHN-IDV--------LSRD------AFR-KIAGD---YA-IE---AKN---RV--
--IFDLIYEYERKR-YEDLPINS-----NPVSSQ----------------KQPALKATSG
KEDSISNIATEIKDGQKSGTVSSQKQPAL-------------------------------
---------KDTSDKDDSV----SNTATEIKDEQKSGTV---------------------
--------------------------------LPAVEQCLNRSLYRP------DAVAQP-
--------VTENEFSL--ESEIISKLYIPKRKIISPRSIKDV--LPPVEEAVDRCLYLLD
RFAQPVTKDKFALESEN------------------IS-EPYFT----NRRTIS-------
------Q---QSAENL-DAACGIDKTENGNMFEDQNV---DKEGK------------A--
------------------------------------------------------------
------------------------------------------------------------
-------------------------------LPA--------------------------
---------------------------T--------------GQKA--NVSPEQPPLF--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------THTVKD
RDHISTRFLGGMDSLTSSEESSERPPLSTLTL-K--------------------------
----------------------------------------EADPSSKAAMRRKDS-----
------------------------------------PPPGKVSSQKQPAEKAT----SDD
-KDSVSNI-----------------------------ATEIKEGPISGTVSSQK------
------QPAEKATSDEKDSVSNIATEI---------------------------------
-----------KKGQQSGTVS--------PQKQSAWKVIFKKKVSLL--NI------ATR
IMGGG---KS--GTVSSQKQPASKATSDKTD----------SALNIATEIKDG-------
------LQCGTVSSQKQPALKAT---TDEEDSVSNIATE-----------------IKDG
EKSGTVSSQKQPALK------------ATTDE---EDSVSNIA----------TEIKDGE
KSGTVSSQKQPALKATTDEKDSVSNIA------TEIKDGEKSGTVSSQKPPALTATSDEE
GSVLSIARENKDGEKS-RTVSSRKKPALKATSDEKDSFSNITRGKKDGEISRKVSSQKPP
TLKGTSDEEDSVLGIAR---ENKDGEKSRT---------VSSEKP----------PGLKA
------SSAEKDSVLN--------IARGKKDGEKTKRVS----------S---RKKP---
-S---------L-------EATSDEKD-SF-SNI-TREKKDGEIS-----R---KVSSQK
PPALKGTS---------------DEEDSVLGIARENKDGEKSRTVSSEKPPGLKATS---
-----------------DEKDS-VLNIARGKKDGEKTRTVSSQ-----------------
-K---------------------------------------------------------P
PTLKATSDEEDSVLSIARE----------NKDG-------EKS-------------RT--
----------VSSEKPSGLKATSAEKDSVLNIARGKKYGEKTKRVSSRKKPALKATSDEK
DSVLYIA-REKKDGEKSR------------------------------------------
-------TVSSPKQPA-----------LKAICDKEDSVPNMATEK-KD------------
EQISGTVSCQKQPALKATSDKKDSVSNIPT-------E--I----------KDGQQSGTV
-----------------------------------SSQKQ--PAWKATSVKKDSVSNIAT
------------------------EIKDGQIRGTGILEYTFNV------------MFDQI
EEKFTSLNKSAGVSPQK---------Q-------SAQKVIFKKKVSLLNIATRITGGWK-
-------------------------------SGTEYPENLPTLKATIEN-----------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------KN-SVL-NTATKMKDVQTSTPA
EQDLEMA------SEGEQKRLEEYEN-NQPQVKNQIH---------SRDD----------
-------------------------------------------------------L-DDI
IQSSQTVSEDGD--SLCCNCKNVILLIDQHE---MK--CKD--CVHLLKIKNT----FCL
WKRLIKL---KDNH-------------------CEQLRVKIRKLKNK-------------
--ASVLQ----KRISEKE---EIKSQLKHEILE-LEKEL--CSLRFAIQQEKKKRRNVEE
VH-QKVREK----LRITEEQ------------------YRIEADVTKPIKPALKSAEVEL
KTGGNNS-----------------------------------------------------
---------NQ-VSETDEK-ED---LLHE------NRLMQDEIARLRLEKDTIKNQNL--
EKKYLKDFEIVKRKHEDLQKALKRNGETLA--------KTIACYSGQLAAL-T------D
ENTTLRSK-----------------------------------LEKQRESR---------
--QRLETEMQSYHCRLNAARCDH--DQSHSSKRDQE----LAFQGTVDKCRHLQENLNSH
-------VLILS--------------------------L-QLSKAESKSRV--LKTELHY
TG-EALKEKALV-FEH--VQSEL--KQKQSQMKD-----IEKMYKS-GYNTM------EK
CIEKQ----ERFCQLKKQNMLLQQQLDDARNKA---DNQEKAILNIQA----RCDARVQN
LQAEC-RKHRLLLEEDNKMLVNEL-NHSKEKECQYEKEKAEREV--AVRQLQQKRDDV--
--LNKG------SATKALLDASSRHCTYLENGMQDSRKKLDQMRSQ-FQEIQDQLTATIR
C-----------------------------------TKEMEGDTQKLEVEHVMMRKIIKK
QDDQIERLE----KILQHS-----------------------------------------
------------------------------SLM-------------------LQVFE-S-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
-----------------------------

------------------MR--VGEWFLRAWRRHVA------------------------
------------------------------------------------------R-----
----------------------W-----------------RKNH---HKDGDGFSNTRYR
IRPKDLGM-----IHR---------------AAIAGDV----------------------
NK---VDQILL-L-----------------------------------------------
------------------------------------------------R-----------
-VNEINAVICAENCCK-CFTYPNITDMY----GN--TALHYAI-DNENISMAGKLLAYGA
DIEARSQG-E---LTSLL------LAINRKKERMVA-FLLKKKPDLTAID----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------NFQR---------------TALILAARN---G-----
------------------------------------------------------------
--------------------------------------------------------STSI
VDQL--------------------------------------------------------
-------------------------------------------LQHNIDV----------
-----VFQDISG------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------WAAEDY--------AVAYTH-----------LDV
IINR-----SIIKT------------------------------------N---TR----
------------------------------------------------------------
------------------------------------------------------------
-------YI----------HCST-V-------------YNKQDL----------K-----
---------------------------------------MTSEGE----------QEKL-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------QGCENNQQQVAEKMKTC---RNKKM
EVSR--------------------------------------------------------
------------------------------N-----------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------LHADYSDS---DDDEL-IQER----------
--RSR------K------------------------------------------------
------------------------------------------PD----------------
------------------------------------------------------------
---------------------------------NHQFP----------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------R
-------------------------------------------Q----------------
-------------------KSEE------LAKKTSNKKNK--------------------
---------------------------------------------VKRHVHFKDDL-DDI
IQSSETTSEDDELP--YSDDKNFMLLIEQHR---VE--CK--DFVSLLKIKNA----ASA
HQRLVEH---KRYY-------------------CEQLTVKFQKMKNK-------------
--ISTLQ----KELSETD---KTESQSEHQKLE-WKQDI--FNHRLILQQEEKRR--KPE
KY-EKGTEE----FEIMEKQ------------------YWTQAGAKKQLQLTLKSLEMKL
KTVRN-------------------------------------------------------
---------------------N---LYQK------NHLMQDEMARLWLEIDTVKHQNQEN
ENTYFKDIEIIKKKSEDLEKTLKLNEETLT--------KTINWYSEKLNAL-TL-----D
KNTVLNSE-----------------------------------LEKEKQRK---------
--QRLETEVELYSCRLTAVLCDR--DQSQSSKRDLQ----LAFQNTVNQWCHLQENMNSH
-------IQILC--------------------------Q-QLSKAESKSSG--LETELHC
ES-EALKKKTLA-IEH--MQRVI--SQTPRRLKA-----IEHMYQN-AQHIV------EK
YVRKQPSVEDELFQIQSQNALHQQQLNDAHKQA---DNQEKLIINIQA----KCEDTVEK
LQAEC-RKHCILLEENNKGLIEEY-ALLKERQCQYEKEKEEEEV--VVRKLKRELGDA--
--LNKQ------LLSEGMLEISSQRQNTLEDETRDTKKKFGLMRSQ-VCMKLSMSTVTL-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-----------------------------

-----------------MKNLVHG----IK------------------------------
---------------------------------------------------------EKT
PMGF--------------CDVPRKNLFDFLH--------------DM-----KSISVSNE
PRYKPLIK-----IHQ---------------AASEGDA----------------------
ER---LQRMISLG-KHS--VH-DRDCK------------------QRTAL----------
----------HYAC--AYGQVEVVNFLLKNNCDVDA--IDMNSVTPLMK-----------
-AVQNWTYECVCTLL-KHGADPNHMDKD----GN--TSLHYAV-SEGNQILAKCLLKYSA
DMEQKNKD-G---FTPLL------QALKENKIEMAK-FLVMNGAN--------IHVF---
-DYM--------------------------------------------------------
--------------------------------K-WTALR---YA-IE---GTS---K---
-GIREILTDYDEKLRVKHKNGNSAYKNSEDN---------------------SLAKYPN-
GPTLGSNLPKSKEENSGFNDKLSS------SKYAPDKCSSNLCGAGDQRIKNEMKGTMEA
Q------VWMHPTL----------KSSVEGKV-----PILKEARKTAKSYHFLI------
------------------------------------------------------------
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-----------------------------

MVA-----EVSSIPAASAVKKPFGLRSKMGKWC---------------------------
----------HHCFPCCRASGKSN-----------------------------------S
NVGTSGDHHDSAMKTLRSKMAKW-CCHCFPRCKGRGESNVEAWEDYDD---SAFMEPRYH
VRGEDLDK-----LHR---------------AAWWGKV----------------------
PR---KDLMVMLRD-TD--VN-KTDKQK------------------RTAL----------
----------HLAS--ANGNSEIVKLLLDRRCQLDV--LDNKKRTALIK-----------
-AVQCQEDECALMLL-EHGTDPNIPDEY----GN--TALHYAI-YNEDKLMAKALLLYGA
DIESKNKH-G---LTPLL------LGIHGQKQQVVK-FLIKKKAN--------LNAR---
-DRCER-------I----------------------------------------------
------------------------------------------------------------
---CQLLSDCKEKQMLKISSEN--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------SNPGN-----------
---------TCDSELL--------------------------------------------
------------------------------------------------------------
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-----------------------------

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-------------------------------------------------------QLNYD
LSRERGHNDFLA--------------------------Q-QLEEADSEVNS--LQNQLIH
LH-YSYREKVLI-LES--TERAL--HQAQFHIKE-----LKRINNI-QNEKQ------QE
YTAKEECFQGKLAEIHSENMVLQQQLENAPERV---IIKKKVVKDVQV----NFSDPFAK
VHADR-EKQVLLVKERNKELIDDC-NHSREQGCTYEKEQREREG--TIKELQQQLADA--
--LKRQ------STLEVFLEVIFCYIHDLEDKKQQLQKETE-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------EIKSKEELAQQVEAASSKCNQLEWT-----------
-IQGL--RQELLSKESLEEKNGKLEKEKSQLEEEIANLKHR---FKM-TMLEHRQVEQY-
KSEVDEQATQEI-IGKLRTIKL---FLQTQAA-FQNNTEQ-LREN-HQAPRVNEMEWRMK
YMEAEL-STLRSSYQDA------E-EQLERNT----QLYFKELKANESLS-KELDRANRR
LLKVSAKLRNERQR---NETLRA------SFTASPVLGPPPTEPPNSSSLLNGGLIPRGN
RTC-FE------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

-------------------MRLFGTR----------------------------------
--------------------------------------------------------TEPE
TCGP--------------TSP----RRDVGI-------------------NGATAKDGYR
IRKKFLGK-----LHR---------------AALSGDC----------------------
RK---IQWLLLAK-GKD--IN-KVDDL------------------NRTAL----------
----------HLAC--AAGYPDVVSFLVERHCKLDI--CDSNHRTPLMK-----------
-AVQCQQEECVSILL-LHGADPNMVDES----SS--SALHYAA-AGENLRIVERLLESKA
NMEARDKL-G---LTPLL------LAVKNHHEAMVD-LFLKNGAN--------VNAK---
-DNSKR-------TA-LMMAIS--NKFNPTSLVQ--------------------------
--LILQYD-VDL--------SCED------DFG-WTIRD---YV-RI---SNT---ER--
--LHESILPHKKKMNFEEK-------------------------------KQPE------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------ADMPLKTIR-----------------------------
-----------------------------------------------EQIRREEK-----
-----------------------------------------LSSK---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------E--VEKK-----------------
--------QS--LEVAEQNQ----------------------------------------
------------------------------------ARE-----------------PRPG
GN---NLTQVNAKFR-------------------------HFA-----------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------SRF-----PLKK-
------------------------------------------------------------
---------------------------------------EKEKQS-----R---------
------------------------------------------------------------
-------------------AGMPLKTIREQIRRKEKLSSKEVE-----------------
------------------------------------------------------------
KKQSLEEPEQS-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------QT-----------TKLRLGE----NNL-TQK-KQ------------
-------------SL-------------------------------------------EV
-----------------------------------AEQSQ------------------TT
------------------------KLR----LGENNLT----------------------
---------------------------------------------------QQSK-----
-------------------------------AG--MP--LKTI-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------REQIR---------RKEK----------
-------------------------------------------------------L-S--
------------------------------------------------------------
-----------SKE-------------------V--------------------------
--------------------------------------------EKKQSLEKEKQPKAGM
FF-KTIREH----LRRKEKL------------------YSEGVEMKQSYQLTVQSLDREP
RPGGNNL-----------------------------------------------------
---------KQ-IPDYHEKEKP---VLQK------NNLLLDEIGVFLLAGDTGKIEKREK
ESRHIKENEVSKEKTDELQKKLKLSEETLR--------TKLSEANKQLNFL-M------I
KNRKLTSK-----------------------------------WKKEKQKR---------
--ARVGKDK--QSCHLCSAIPDP--KQCQTSKQDLA----YAFQQERDEWLRIKDQLNYD
LSRERDRNDFLA--------------------------Q-QLEEADSEVNS--LQNQLIH
LH-CSYREKALI-LES--TERAL--HQAQFHIKE-----LKRINNI-QNEKQ------QE
YTAKEECYQGKLPEIHSENMVLQQQLENAPKRV---IIKKKVVKDVQV----NFSDPFAK
VHADR-EKQVLLVEERNKELIDDC-NHSREQGCTYEKEQKEREG--TIKELQQQLADA--
--LKRQ------STLEVFLEVIFCYIHDLEDKKQQLQKETEEIKSK-LRESEGRHPKAEP
W-----------------------------------TNDLEDGEQKLEMENGRLEATAKE
LLGKMEEME----ENLLDP-----------------------------------------
------------------------------KWLDPERG-KGKTL---VELKQSLVAS-LD
DQRKRNEEVE-QDIGRPRK-----KKLEE--------------DDKGD------LASQ--
--EA-LKQACSQ----VEDAQMNTLRNQKEELAQQVEAASSKCIQLEWT-----------
-IQGL--RQELLSKESLEEKNGKLEKEKSQLEEEIANLKHR---FKM-TMLEHRQVEQY-
KSEVDEQATQEI-IGKLRTIKLFL---QTQAA-FQNNTEQ-LGEN-HQAPRGNEMEWRMK
YMEAEL-STLRSSYQD-----A--EEQLERNT----QLYFKELKANESLS-KELDRANRR
LLKVSAKLRNERQR---NETLRA------SFTASPVLEPPPTEPPNSSSLLNGGLIPRGN
RTC-FEQ-----------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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-----------------------------

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-------------------------------------MLQEEIARLRLEIDTVKNLDQQK
ENNYLEDIKIVKEKNDFLQNTLKLNEETFT--------TTIFQYSVQSEVL-KA------
ENEMLSFK-----------------------------------LEDENQNQ---------
--ERLETEIESYRCRLAAAIQDC--DQSQASKRDVE----LDFQRTRQEWFHLKEKMNFD
MSNLKDKNEMLS--------------------------E-KLSNAENKIRS--LKMKWHH
TK-DALREKTLV-LED--VQRDL--TQSQCQRKE-----IEQMFQN-EEDKV------SK
YIQKQESLEERLSQIQNENLLLRQQLNEAHKKA---DNQEETIINIQE----HFNAIVKN
-QAQR-EEQSLLLEQENNKLINKC-NYINKRLYKYEKEKAERNV--SIEKEN--------
------------------------------------ILKLLERKYK-AIFGFC-------
------------------------------------------------------------
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-----------------------------

MEEDFEY-------DALALK--F------P------------------------------
---------------------------------------------------------RRG
RWYT--------------RL--WRSCPGFGC--------------LR--QKKTTKFPLYL
IGYDPVGR-----LQR---------------AACVGDV----------------------
EK---IESMIHEC-HHH--VD-ESDWR------------------GRTSL----------
----------HYAS--AHNHPDVVTLLLENKSNINI--QDDEGCTPLIK-----------
-AAQRDNTHCVCVLL-RHNANPNLMDYS----GN--TAFHHAI-SRGSIAIVKMLLEYNV
DIEAKTEY-G---LTPLQ------LATYENHTEMIK-FLESKSA----------------
------------------------------------------------------------
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-----------------------------

------------------MNKLFSFWKRKN------------------------------
--------------------------------------------------------ETR-
-------------------------------------------------------SQGHN
LREKDLKK-----LHR---------------AASVGDL----------------------
KK---LKEYLQIKK-YD--VN-MQDKK------------------YRTPL----------
----------HLAC--ANGHTDVVLFLIEQQCKINV--RDSENKSPLIK-----------
-AVQCQNEDCATILL-NFGADPDLRDIR----YN--TVLHYAV-CGQSLSLVEKLLEYEA
DLEAKNKD-G---YTPLL------VAVINNNPKMVK-FLLEKGAD--------VNAS---
-DNYQR-------TA-LILAVS--GEPA--CLVKL-------------------------
--LL-QQG-VEL--------CYKG------IVDSQLRNM---FT-SM---VLL---HR--
--YPQFTVSHGKKKHA--K-----------------------------------------
------------------------------------------------------------
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-----------------------------

------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------FPQYH
IKLSHLKR-----IHR---------------AVFYGNL----------------------
EK---LEYLLLTYH--D--AIRETRTK------------------GKTAL----------
----------HLAC--ATGQPEMVFLLVSRGCELNL--YDREGRTPLIK-----------
-AVQLRQEACATILL-QNGADPNIMDLF----GR--TALHYAV-YNEDTSMIEKLLLYGT
NIEECGKY-E---YQPLL------LAVSRRKVKMVE-FLLKKKAN--------VNAI---
-DYLSR-------SA-LILAVT--LGEK--DVVILL------------------------
---L-QHN-IDV--------FSRD------AYG-KLAED---YA-LE---AKN---RV--
--LFGSQNVQ--------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-----------------------------

MVA-----EVCSMPTASTVKKPFDLRSKMGKWC---------------------------
----------HHRFPCCRGSGKSNMGTSGDHDDSFMKMLRSKMGKCCRHCFPCCRGSGTS
NVGTSGDHENSFMKMLRSKMGKW-CCHCFPCCRGSSKSNVGAWGDYDH---SAFMEPRYH
VRREDLDK-----LHR---------------AAWWGKV----------------------
PR---KDLIVMLRD-TD--MN-KRDKEK------------------RTAL----------
----------HLAS--ANGNSEVVQLLLDRRCQLNV--LDNKKRTALIK-----------
-AIQCQEDECVLMLL-EHGADRNIPDEY----GN--TALHYAI-YNEDKLMAKALLLYGA
DIESKNKC-G---LTPLL------LGVHEQKQQVVK-FLIKKKAN--------LNVL---
-DRYGR-------TA-LILAVC--CGS-A-SIVNL-------------------------
--LL-EQN-VDV--------SSQD------LSG-QTARE---YA-VS---SHH---HV--
--ICELLSDYKEKQMLKISSEN--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------SNPEQ-----------
---------DLKLTSEE------------------ESQ------------RLK-------
--------------------------------VSENS-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------QPE--------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------KMSQEPEINK-----------
---DCDREVE--------------------------------------------------
---------EEIKKHG--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----SNP------------------------------VGLP------------------
------------------------------------------------------------
-----------------------------------------E-------NL---------
--------------------------------------------------TNG-------
------------------------------------ASA---------------------
---G---------NG---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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----------------------------------------------D-------------
--DGLIP----QRRSRKP---ENQ-----QFPD-TENEE--Y-HS---------------
------------------------------------------------------------
------------DEQNDTRKQLSEEQNTGISQDEIL-----TN---K--QKQIEVAE---
-QKMNSELSLS-----HKKEED---LLRE------NSVLQEEIAVLRLELDETKHQNQLR
ENKILEEIESVKEKTDKLLRAMQLNEEALT--------KTNI------------------
------------------------------------------------------------
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-----------------------------

-------------------MKLFGFGSRRG------------------------------
--------------------------------------------------------QTAQ
GS----------------------------------------------ID-HVYTGSGYR
IRDSELQK-----IHR---------------AAVKGDA----------------------
AE---VERCLARRS-GD--LD-ALDKQ------------------HRTAL----------
----------HLAC--ASGHVQVVTLLVNRKCQIDV--CDKENRTPLIQ-----------
-AVHCQEEACAVILL-EHGANPNLKDIY----GN--TALHYAV-YSESTSLAEKLLSHGA
HIEALDKD-N---NTPLL------FAIICKKEKMVE-FLLKRKAS--------SHAV---
-DRLRR-------SA-LMLAVY--YDSP--GIVNI-------------------------
--LL-KQN-IDV--------FAQD------MCG-RDAED---YA-IS---HHL---TK--
--IQQQILEHKKKILKKEKSDVG-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------S--------------
----------SD--ES--A-------------------------VSIFHEL---------
------------------------------------------------------------
--------------------------------------------R---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------V----------------------------------------------------
------------DSLPASD-----------------------------------------
------------------------------------------------------------
----------------------------------------------------------DK
-DLNVATK--------------------------------------------Q-------
------------------------------------------------------------
-------------------------------------------------CV--PEKVSEP
LPGSS-------------------------------------------------------
-------------HEKGNR-------------------------------------IVNG
QGE---------------------------------------------------------
------------------------------------------------------------
-------------------GPPAKHPSLKPS-T---------------------------
---------------------------------------------------EVEDPAVKG
------------------------------------------------------------
----------------------------AV-------QRKNVQTL---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------RAEQALPVASEEEQERHER--SEKKQPQVKEGNNTNKSEKIQL--SEN---
------------------------------------------------------------
------------ICDST-------------------------------------------
--------------------------------------------SS--------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------AAAGR-LTQQRKIGKTYPQQFPKK-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------L-----------------------------------------------------
-------------------------------------KE--EHDRCTLKQENEEKTNVNM
LY-KKNREE----LERKEKQ------------------YKKEVEAKQ-LEPTVQSLEMKS
KTARNTP-----------------------------------------------------
---------NR-DFHNHEEMK---GLMDE------NCILKADIAILRQEICTMKNDNLEK
ENKYLKDIKIVKETNAALEKYIKLNEEMIT--------ETAFRYQQELNYL-K------A
ENTRLNAE-----------------------------------LLKEKESK---------
--KRLEADIESYQSRLAAAISKH--SESVKTERNLK----LALERTRDVSV--QVEMSSA
ISKVKDENEFLT--------------------------E-QLSETQIKFNA--LKDKFRK
TR-DSLRKKSLA-LET--VQNDL--SQTQQQTQE-----MKEMYQN-AEAKV------NN
STGKWNCVEERICHLQRENAWLVQQ-LDDVHQK---EDHKEIVTNIQR----GFI-----
---ES-GKKDLVLEEKSKKLMNEC-DHLKESLFQYEREKTEGVV--SIKEDKYFQ-TS--
--RKTI------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

MVA-----EVGSMPAASSVKKPFGFRRKMGKWG---------------------------
----------CHCLPCC-------------------------------------RGSRKS
NVGASGDQDDSAVKTVRS-----------------SKSNVGAWEEYDD---SAFMEPRYH
VRREDLDK-----LHR---------------AAWWGKV----------------------
PR---KDLIVMLRD-TD--VN-KTDKQK------------------RTAL----------
----------HLAS--ASGNSEVVKLLLDRQCQLNI--LDNKNRTALTK-----------
-AVQCQEDECALMLL-EHGTDPNIPDEY----GN--TALHCAI-YNEDKLIVKALLLHGA
AIESKNKH-D---LTPLL------LGIHEQKQQVVK-FLIKKKAN--------LNAL---
-DRYGR-------TA-LILAVC--CGS-A-SLVSL-------------------------
--LL-EQN-IDV--------SSQD------LSG-QTARE---YA-VS---SHH---NV--
--ICQLFSDYKEKRMLKISSEN--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------SNPGK-----------
---------EAEE-----------------------------------------------
------------------------------------------------------------
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-----------------------------

------------------MKKFFRSIKKKA------------------------------
--------------------------------------------------------HESS
-------------------SSNSKDI-----RD----------TGSSSSILTSSNAPGYR
FWFRDLGK-----LHK---------------AASVGDL----------------------
AK---VQRHLLFKK-HD--LN-KRDKE------------------HRTPL----------
----------HLAC--ANGYPDVVSLLVERKCKLNI--RDSENRSPLIK-----------
-AVQSQHEECATILL-ENKAEPNLVDIN----KN--TALHYAV-CGHNVSLVIKLLEHKA
NTEAQNKD-G---HTPLL------LAITENNPEMVS-ILLRKGAD--------VNAA---
-DKFQR-------TA-LMLAVG--GEPT--GIVSI-------------------------
--LL-QYD-VDL--------SCQD------IYG-MTAEG---YA-SC---SGY---SI--
--HYELISQYKNQRNR--KKLIF-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------P--------------
----------EI--SC--P-------------------------ERISAVQF--------
-----------S------------------------------------------------
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-----------------------------

------------------MKKLFGFGSK--------------------------------
--------------------------------------------------------TTVL
SAG-------------------SSGEG---------------------S-SGVNQLPGYH
VRDKDLGK-----IHR---------------AACEGDV----------------------
AR---VQQILLLR-RNG--PN-DKDKR------------------NRTAL----------
----------HLAC--AGGRPAVVTLLAKWKCQLNI--CDSENRTALIK-----------
-AVQCQQEECTSILL-EHGADPNLVDVK----GY--TALHYAA-FGPNISIAAKLLSYNA
NIEARDKD-D---LTPLL------LAVSENQQQMVE-FLLQKEAN--------IHAV---
-DKMKR-------TA-LILAVN--FASS--SVVRL-------------------------
--LL-EQG-VDI--------SPQD------RYG-RNAED---YA-VI---KGH---QI--
--MHNLIL--KYKGEK-GLKTPS------RDTILD-------------------------
------------------------------------------------------------
-------------------------------------------------------RTA--
--------------------------------------------EGP------PRQTSG-
--------ETE---S-------------------------KQ--ASPEK----------H
PHSKPPV-----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------G-VT--NVRKIKVGTKDL
-------------------P----------------------------------------
------------------------------------------------------------
------------------------------------TSRSDRT------------AE--G
-----PP-------------------------------------------------RQ-T
-----------SGETESKQDVPQRPPWASGLG----------------------------
---------------------------------------NSKRA----------------
------------------------------------------------------------
------------------------------------------------------------
---KQEDPRNRG------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------IE---------------------------------------
---E--------------------------------------------------------
-AHTASPEKHPHSKPP--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------VGV--------------TNVRKI-----K---------
-----V--------------------------------------GT----KD--------
---------------------------------------------------L---P----
------------------------------------------------------------
TSRSDRTAE---------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------GPPRQTSGET-ESK-----------
-QDV--------------------------------------------------------
-------------------------------------PQR--PPWASGLGNSKRAKQ---
------EDP-R-------------------------------------------------
--------------------------------------------------NRGI---EE-
-------------------------------AHTASPEKHP-H-----------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------SKP-PVGVTN-------V-
-----------------------------RKIK---V---------GTKD----------
-------------------------------------------------------L-PTS
R--------------------------------------SG--S---L-SLGA----VLS
YRRSLEL---EKSQ-------------------CELLKAKVKNMEST-------------
--ISGLQ----KELSETK---EVKSQLEHQMAE-WQGEL--CSLRLSLKQEEEQRKKADM
LS-EEIREQ----LRREEEQ------------------CSKETELKQQLELTVEGLQGEL
KAVRDRL-----------------------------------------------------
---------NQ-VSDSHERATN---LLHE------NLMIQDEIATLKREIDTIKNENLEK
ERKYLEVIEIVKQKNDELQKAIKLNEEKLT--------Q---TYSGQLHDL-T------A
ENTRLKSK-----------------------------------LKKEEKRQ---------
--KAWKQMLR-YIVPS--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------K-----LHR---------------AAYVGYD----------------------
EP---LRKLLSRK-KNA--VD-SRDKD------------------GRTPL----------
----------HLAC--ISGCPGVVVLLIQFHCDLNA--RDKERTTALIR-----------
-AVQFLNRRCAGILL-EHGANPNLEDGS----QN--TALHYAI-LEESVSIATQLLRHNA
NIEAVNKS-N---LTPFL------LAVKENKKEMVK-FLIENGAN--------VHAV---
-DNVQS-------IY-QL------------------------------------------
--IV-DYR-EGK--------IPKT-------------------P-SQ---NSD---LE--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------VK-------
-FPPRFDDLSISSVSS--I--------------PCID---D---SWHSADD-----DT--
-----------DLAPKK-------------------AWHPRFAKPIQAWQEPT-------
------I------NT-EA-KDGVLKPGTSTSLEDNNSDNKNEDVV----------PTF--
------------------------------------------------------------
------------------------------------------------------------
-------------------------------P----------------------------
---------------------------------QPSTEVPGFSHP--------AFPAPEH
LTSAAV---LAVT-----------------------------------------------
------------------------------------------------------------
--------------------------------------EEEAAKPKIGGK------E---
---NGAQTIN----SVLKEQA---DHKKLV------------------------SIDGAH
KNDKGG----ATSALGLGE----KAVVELSTD------SESTSKIQLPNYVD------QL
SGAAGQGEKNTLNGQIELSC----------------------------------------
--MSGSRNFMAEDP-----------------RNVGIPIAHVESTDMHPHLKPA----VGV
-KDSVPNK-----------------------------SGGMKNLQAFK---SADL-----
------------------------------------------------------------
--------------------------------------DLEM-----------TSKEEQE
GLDGS-----------ENKQSQVKVEENRNKSGELKG---SETVCDATV-KG-LTQRRKR
G---KTDDQQFAALQKEN---SDSSSPGLPMKEVKKNESGK--QTLKAS--VT---SHV-
--FE----KSASLAGGLLHMNDNSSL-----------SEGDLG--HGRSSKKTSAKKDKV
------------------KEQVNS---V--------------------------------
-----------------G--DLDDLTLSPET-ASEDCESP--------------------
--YPN--YKNTLRLIERLGLERKDYGTLLK---------IQNAVHSFRSL--IECKESDC
ELLRG-KVKKMENKVNKL------QKELLEAREMNSQLE--RQNVAWERELCSMEKQYNE
QVLQKQQL-----------------------------------------------ESTLQ
PLKFELKSRRDKPSQQRVRDEWFHSQ--D-------------------------------
--------------------------------------TMNFEVSDPK------------
-DNGEVLPPQLPE-------AESQ-------------------YRGP-EIELHP------
--RREALRP-VTVLECGHR----------DQSQAQ--------------------CSNKK
IEPL----------------------------Y----------------QRK--------
------------------------------------------------------------
Q----G--KVNKY---------------AAK----------QAFL-EDRL----------
--------CELQSEN---MLLRQQLEVAQNEAKSKT-------I----NIPEPFPIVGKA
TRKQLLMLEEGNKELINECKCVKDRMYQ--YETDRAE------------MQA--CVR---
---------------RL----------QQEL-----------------------------
--------------TD--------------------------------------------
-------------------------------TR----KKVSMLEASLEVT----------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------T---AHHQ--T-DIE-NKTQDLERKLNQIA-
---------------------DQN------------------------------------
------------------------------------------------------------
-------------------------------------------ADLTAKLQST-------
TSALLHL---SAET-------------------QLLLK-ELLSMKG--------------
-----MQ----KKCETLQ---EEKKKLEEEVVN----------LKHHLEVNTVERSQV--
---EQYKQE----IEER---------------------AKQ-----------------DV
AAALKELS-QFLQ-----------------------------------------------
---------------TQAAYED---NLLREYKNASISQMKHKIKYLESELKSKTVQLDSE
KKEL-EK----------YRQLYLEEPENRT--------SWASQLHSINERL-V------V
MNTKLQMA-----------------------------------EEYKCSV----------
-LKTIPAR-------PAEK-------FNDSSEH---------------------------
------------------------------KWTLTQS--------ANFRSFSEPST----
-------------------------SVSDCL-FG-----MHKKENN-AAREV------KE
ATPKLQSESYRTPRGSSKESRLIEDML----------------LKACK----EYEEVLKK
NY-TM-L-----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------MRKIF---SKKG------------------------------
--------------------------------------------------------ESPL
ASFP----------------GRRRTGAGVGC----------------EHGNSVYSQPGYH
LRDRDLGK-----IHK---------------AASLGQV----------------------
AK---VQQILLLRK-SG--LN-DRDKM------------------GRTAL----------
----------HLAC--ASGHSEVVTLLVDRKCQLNM--CDSENRTALMK-----------
-AVQCQEEECATILL-EHGADPNLTDVH----GN--TALHYAV-YNENIPITAKLLSHRA
NIEVKNKA-E---LTPVL------LAVNGKKQKMVE-FLVQNKGR--------VNEI---
-DKLKS-------SR-QLISEY--KEEK--IPENPSQNSNSVVDGSSED-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------SLSRLSD--KPGI--------------D----D--SWPTSDD---------
--------EDFDFDTKN-------------------VPKPSLTKLMTASLQSKK---NLE
AQYGTVRT------------------ENTTLIEDSNSDSP--------------------
---------------------E-------------------EDEV---------------
------------------------------------------------------------
-----------------------------EGLPS--------------------------
----------------------------------RSVKVQAFAHPA--FPSPGPHP-APS
LKA---------------------------------------------------------
----------------------------------------SANL----------------
-----------------------------------GHTEDVTTEAATGKKE---------
---NGIGIID----SAPVE--------------QTDDN---------------VTSDGVR
KNN----RSDMMSALGLGQEEDIDSPWDSESI-SETLPQNYVD---------------HL
SGAADEKE-NTVND---Q------VED----------------------------VFYIP
SCMSGSRNFKMAKLEDARNV--------------DIPVTHMESPKRYPHLKPT----TEM
-KDCVPNK-----------------------------AVGVK------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------DI------------------
---------------------------------------------QTYR-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------SA
EHDLEVTSEEEQESLEG-------------RENNQPQVE--------EERKKHK------
---------------------------GKEMQVS---ENLYDGAAADS------------
-----DDGGLIQ---------QRKTGNID----NQQFTRKEKENF---------------
---------ANGGPALHMKE-VRKNDN--EKWTSKESVMTPVLEKASLL-----------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------MGGLLQVNDDSSSSE-
-------------------LDEDEG---RPAKKTSTGKNE---VKNQLYSMD--------
------------------------------------------------------DL-DDL
TRSSETASEDCELP--YSNYKNIMLLIEQLG---KD--CKDTDSVSLLKIQDA----FLS
CERLMEL---KKNH-------------------CEQLTVKVKKMESK-------------
--VSVIQ----KELSETK---EIKSQLEHQKVE-LEQEL--CSLRFTLKQEEEKRKNADM
LY-EKNREQ----LRRKEEQ------------------YRKEVEAKQQLELTLRTLDMEL
RTVKNNLD-QVVQERNDTQRQLSREQNARILQDGIL-----TNHLCK--QREIEMSQ---
-KKMDSETSY-----GHEKEDD---PLHK------NHMLQDEIAMLRLEIDTIKIQNQEK
EKKYFEDIEIVKEKNDDLQRTIKLNEETLT--------KTISQHNGQLSVL-T------A
ENTMLNSK-----------------------------------LENEKQIK---------
--ERLEAEVESYRSRLAAAVHDC--DQSQTSKRDLE----LAFQRARDEWFRLQDRMNFD
LSNLKDNNEILS--------------------------Q-QLSKTESKFNS--LEIDLHH
TR-DALREKTLV-LER--VQRDL--SQTQSQMKE-----IEQMYQE-EQGKV------NK
YIGKQESVEERLSQLQSENMLLRQQLDDAQNKA---DSKEKTVINIQD----QFHAIVEK
LQAES-EKQSILLEERNKELISEC-NHLKERQYQYENEKAEREV--VVRQLQQELADT--
--LKKQ------SMSEASLEVTSRYRISLEDETQDLKKKLGQIRSQ-LEEARDQHTEAVR
C-----------------------------------VEKMQDHVQKLEKENSKLKVTIKK
QTDKIEQLQ----KNLLIA-----------------------------------------
------------------------------SSHEDEKE-QLKKL---SELKQSLEYN-LN
QEMKKNGELEKEISGFKNL-----LKMTR--------------KKLHE------YENG--
--EC-NFYEDLKTSQYEMDTQIKKLKHKIDDLTAQLESSSSKCLHLDAK-----------
-NQIL--QEELLSMKTMQKKCEKLQKNKKKLEQEVVNLKSQ---IEM-NIVERGQVEQY-
KQEIEERARQDI-VEKLKEVNL---FLQTQAA-SQENLEQ-LRES-HISSMRSQMELRIR
DLESEL-FKMKTSQE------DFNKAELEKYK----QLYLEELKVRKSLA-TKLSKTNEK
LAEVSTKLLVEKQQ---TRSLLT------TLATRPVLESPCVGNVNNGLALNRKHTPREN
LLI-PTLNPRASNNS-MESYLTKMQQELEKNITRELEEA-AAE-----LET-----E---
--------------------SCIASPVGST---------DES----NLNHDLVWKASREY
VQILQKN--YML------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------MRKFFSFGRRLG------------------------------
--------------------------------------------------------QALL
SS----------------------------------------------RD-KEYAGRGYH
TLDWELRK-----IHR---------------AAIKGDA----------------------
AE---VERCLKRRF-WD--VD-ARDRK------------------DRTVL----------
----------HFAC--VHGHIEVVTLLLRRRCQIDI--YDRLNRTPLMK-----------
-AVHCQEEACAIILL-ERGANPNIKDIY----GN--TALHYAV-YNKGTSLAEKLLSHHA
NIEALNKE-G---NTPLL------FAINSRRQQMVE-FLLKNQAN--------IHAV---
-DNYRR-------TA-LMLAVQ--HNSS--SIVSL-------------------------
--LL-QQN-VNI--------FSQD------MFG-QTAED---YA-VC---CDL---RR--
--YVLI------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
-----------------------------

------------------MKKIFGFESWKG------------------------------
--------------------------------------------------------KSPF
ESLT--------------SQQKT--------NT----------GLTPEACNSITSWNRYH
IRDKDLRK-----IHR---------------AASVGDA----------------------
QE---MEEILLKSL-RH--LN-DRDKM------------------NRTAL----------
----------HLAC--ANGHPKVVALLADSKCRLNL--CDNENKTALIK-----------
-AVQCQEEECATILL-EHGADPNIMDIY----GN--TALHYAV-AGHDMDMAAKLLSYKA
NIEARNKD-E---LTPLL------LAITENKQQMVE-FLVKKNAN--------VHAV---
-DKMKS-------NC-KLISEY--EEQR--RCEESSQNSN--------------------
--PV-NES-SEGDSVSRILRKPGL------DDS-WPESDNEDFG-FA---TK--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

MVA-----EVCSMPAASAVKKPFDLRSKMGKWC---------------------------
----------HHRFPCCRGSGTSNVG----------------------------------
---TSGDHDDSFMKTLRSKMGKW-CCHCFPCCRGSGKSNVGTWGDYDD---SAFMEPRYH
VRREDLDK-----LHR---------------AAWWGKV----------------------
PR---KDLIVMLRD-TD--MN-KRDKQK------------------RTAL----------
----------HLAS--ANGNSEVVQLLLDRRCQLNV--LDNKKRTALIK-----------
-AVQCQEDECVLMLL-EHGADGNIQDEY----GN--TALHYAI-YNEDKLMAKALLLYGA
DIESKNKC-G---LTPLL------LGVHEQKQEVVK-FLIKKKAN--------LNAL---
-DRYGR-------TA-LILAVC--CGS-A-SIVNL-------------------------
--LL-EQN-VDV--------SSQD------LSG-QTARE---YA-VS---SHH---HV--
--ICELLSDYKEKQMLKISSEN--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------SNPEQ-----------
---------DLKLTSEE------------------ESQ------------RLK-------
--------------------------------VSENS-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------QPE--------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------KMSQEPEINK-----------
---DCDREVE--------------------------------------------------
---------EEIKKHG--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----SNP------------------------------VGLP------------------
------------------------------------------------------------
-----------------------------------------E-------NL---------
--------------------------------------------------TNG-------
------------------------------------ASA---------------------
---G---------NG---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------D-------------
--DGLIP----QRKSRKP---ENQ-----QFPD-TENEE--Y-HS---------------
------------------------------------------------------------
------------DEQNDTQKQLSEEQNTGISQDEIL-----TN---K--QKQIEVAE---
-KEMNSELSLS-----HKKEED---LLRE------NSMLREEIAKLRLELDETKHQNQLR
ENKILEEIESVKE---KLLKTIQLNEEALT--------KTSI------------------
------------------------------------------------------------
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-----------------------------

---------------------MKTHRSKMAKWC---------------------------
----------CHCLPRCTGSGE-------------------------------------S
NVGASGDQDDSAMKTHR--------------GRGESQSNVEAWEDYDD---SAFMEPRYH
VRGEDLDK-----LHR---------------AAWWGKV----------------------
PR---KDLIVMLRH-TD--MN-KTDKQK------------------RTAL----------
----------HLAS--ANGNSEIVKLLLDRRCKLNV--LDNKKRTALIK-----------
-AVQCQEDECALMLL-EYGTDPNIPDEY----GN--TTLHYAI-YNEDKLMAKALLLYGA
DIESKNKH-G---LTPLL------LGIHGQKQQGVK-FFIKKKAN--------LNAR---
-DGCGR-------S----------------------------------------------
------------------------------------------------------------
---CQLLSDYKEKQMLKISSEN--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------SNPGN-----------
---------TCDSEYR--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-----------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TAL----------
----------HLAC--AKGHVEVVNFLIGRQCLIDA--IDNADMTPLMK-----------
-ATQCNQEKCAIILL-EHGADPNHTDRN----GN--TALHYAI-YNENTGIAKQLIQHNA
DIKLRNKD-D---LTPLL------VAICAKRENTVD-FLVKNNDI--------FHAL---
-DNMDX-------XX-XXXXXX--XXXXX-------------------------------
--XX-XXX-XXX--------XXXX-------------------X-XX---X---------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------X---------------------
------------------------------------------XXXXX--XXXX-------
-XXHESSEDSVSRFCN--K--------------FGHV---D---HLIAPGV----EDF--
-----------NLFTM--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-----------------------------

------------------MKKIFDLRSK--------------------------------
--------------------------------------------------------KGKS
PLGS--------------FTIPGRDRG---------------------H-HRTSFQPGYH
IRDRDLGK-----IHK---------------AASVGNV----------------------
AK---VQQVLLLG-KNG--LD-DKDKM------------------NRTAL----------
----------HLAC--TNGHSAVVTLLLERKCLLNL--CDSENKTALMK-----------
-AVECQEEECATLLL-EHGADPNVVDVN----GN--TALHYAV-FCQNISLAAKLLSYNA
NIEARNKD-D---LTPLL------LGISERKQQIVE-FLVRKEAN--------IHAV---
-DKMKR-------TA-LILAVN--YESL--NVVSL-------------------------
--LL-QRG-ADV--------FSQD------VFG-RTAEE---YA-VI---SGF---KI--
--EEFREYSELLKKLI-VPQQR--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------LR----ST--RVAY---KFSNK----------------PGV-----------
------------------------------------------------------------
---------------------------DSQ----------FASDD---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------EVLDFETV
---------------NNGVPLTV-------------------------------------
------------------------------------------------------------
-----------------------------------LLNSEGG------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----VKK-----------------------------TMGFKIYSDRH------------
---HSLDP----------------------------------------------------
------------------------------------------------------------
-----------------YDDK---------------------------------------
--------------K-----DAT---AEMED------FK-----------------VT--
--IR--------------------------------------------------------
-NDN--------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------KEEISM--------------MSA--L-----G---------
-----L--------------------------------------GE----EKDIES----
--------------------------------PWDSEENKVEG--EKK---H---RSSEV
KV---------------------------------------------------------S
DNVCDAAAES--------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------RLIQQRKSGG-NNK-----------
-QAFPAMESKGSDSSDRGVPRKETE-----------------------------------
------------------------------------KKNN--GKWTQDERVIAPILK---
-----KTDS-LTGGL---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------LHVNDD----SIL
RK---------LID-------------------CMTLSV-NYYNKLI-------------
--VH------------------------------------------------------SY
YC-TG-------------------------------------------------------
------------------------------------------------------------
-----------------REAKH---QLRK-------NHMQDAVASLRLEIDTVKNQNQEQ
EKKCFEDIETAKGD-EYPQKANKLNKETLT--------KAIFQHAGQLNVP-I------A
ENTMLNPE-----------------------------------LENAKQSK---------
--QRLETEVESYRSRLAAATQDH--DQGQTSQRDLE----LASQKAEEKRLRLQDQMKFD
MAKLKSNNEMLS--------------------------Q-QLSKEKNKVSQ--LNIKLHQ
TR-DDLREKTLM-LDR--VQRDL--CQAECQRQE-----IERMYQN-KQGKV------NE
YPGKQESLEERLSQLQSENGIM--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
-----------------------------

------------------MKKIFGFRSKG-------------------------------
--------------------------------------------------------PSPL
GPSA--------------RPRNS--------SV----------GFGR-VSAGGSHMPRYH
IHDKDMGK-----IHK---------------AASVGDV----------------------
AK---VQHILILGK-SG--VN-DRDKK------------------DRTAL----------
----------HLAC--AYGHPEVVTLLVERKCDIDA--CDGENSTALIK-----------
-AVQCEEEECAAILL-EHGADPNVADSS----GN--TALHYAV-QGENTSIAAKLLAHGA
NIEAKNKD-D---LTPLL------LAVKENKQHIVE-FLVKKKAS--------IHAV---
-DQLGS-------NR-QLLEYD--GERL--KYSEN---SN--------------------
--PV-DNG-SEEESLTRSSNTPDP------ADS-WPTSDEDDYN-FD---NKN---VP--
--KINLTELWTAAQRSKKNQTKC-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------G--------------
----------FE--NL--G-------------------------SRILLDN---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----SNS-------------------------------------------NS-------
------------------------------------------------------------
-------------------------------------------------ED--EDGV-EI
GPGPP-------------------------------------------------------
-------------ARVQTF-------------------------------------S-PS
S-----------------------------------------------------------
------------------------------------------------------------
--------------------PYTALTLLRS------------------------------
--------------------------------------------------------AF--
------------------------------------------------------------
------------------------------------------------------------
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-----------------------------

------------------MKRLLAAAGKG-----V-------------------------
--------------------------------------------------------RGPE
PPNP--------------FSER-----------------------------VYTEKDYGT
ICFGDLGK-----IHT---------------AASRGQV----------------------
RK---LEKMTVGKKPVN--LN-KRDMK------------------KRTAL----------
----------HWAC--VNGHAEVVTFLVDRKCQLNV--LDGEGRTPLMK-----------
-ALQCEREACANILI-DAGADLNYVDVY----GN--TALHYAV-YSENLLMVATLLSYGA
VIEVQNKA-S---LTPLL------LAIQKRSKQTVE-FLLTKNAN--------ANAF---
-NESKC-------TA-LMLAIC--EGSS--EIVGM-------------------------
--LL-QQN-VDV--------FAED------IHG-ITAER---YA-AA---CGV---NY--
--IHQQLLEHIRKLPK-N-PQNT-----NPEGTS------------------------TG
TPDEAAPLVERTPDMAESLVEKTPD-----------------------------------
------------------------------------------------------------
-------------------------------------------------------EAAH-
--------LVEGT-SA--K--I---QCLGKAT-SGKFEQSTE--ETPRK--------ILR
PTKETSE--KFSWPAKE-------------------------------------------
-----------------------RP-RKIT----------WEEKE------------T--
------------------------------------------------------------
------------------------------------------------------------
-------------------------------SVK--------------------------
---------------------------T--------------ECVA--GVTPNKTEVLEK
G-------------TSNMIACP--------------------------------------
------------------------------------------------------------
-----------------------------------TKETSTKASTNVDVSSVEPIFSLFG
-----TRTIENSQCTKVEE--DFNLATNIISKSAAQNYMCL--------PDAAYQKDIKT
INH---KIEDQMFPSESKREEDEEYSWDSGSL-FESSA----------------------
----------KTQVCI-----------------------PESIYQKVMEINREVE-----
------------------------------------ELPEKP-----SAFKPA----VEM
-QKTVPNK-----------------------------AFELKNEQ--TLRAAQM---F--
PSE-SKQKDDEENSWDSESPCETVSRK---------------------------------
------------------------------------DVYLPKATHQK--EF---------
---DT---LNGKLEESPVKDGLLKVITFILK----------H------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------ILC------------------------------------------------
--------------------------------------------------------I---
-N---------F-------CPTCGRKV-SL-PNK-ALELKDRETL-----KAE---SPDK
DGLLKPT---------------CGRKVSLPNKALELKDRETFKAAQ----MFPSESKQK-
---------------------DDEEH------SWD------------F---E---SFLET
LL---------------------------------------------------------Q
NDVCLPKATHQ-------------------------------------------------
----------KEFDTLSGKL----------------------------------------
------------------------------------------------------------
-------EESPDKGGL-----------LKPTCGMKISLPNKALEL-KDR-----------
-ETFKAVDVSSVES-TFSLFGKPTTENSQSTKVEEDFNLTTKEGTTKTVTGQQECDIGII
E---------------RAPQDQTNKMPT--SELGRKEDPK--STSDSEIISV--------
------SDTQNYECLPEATYQKEIKTTNGKIE----------------------------
------------------------------------------------------------
----------------------------------ESPEKPSHFEPATEM-----------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------QN-SVP-NKGLEWKNKQTLRA-
-----------------------------D------------------------------
------------------------------------------------------------
-------------------------------------------STTLSKILGA----VPS
CERGREL---KKDN-------------------CEQITAKMEQTKNK-------------
--FCVLQ----KELSEAK---EIKSQLENQKAK-WEQEL--CSVRLTLNQEEEKRRNVDI
LK-EKIRPEEQ--L-------------------------RKKLEVKQQLEQTLRIQDIEL
KSVTSNL-----------------------------------------------------
---------NQ-VSHTHESEND---LFHE------NCMLKKEIAMLKLEVATLKHQHQVK
ENKYFEDIKILQEKNAELQMTLKLKQKTLT--------KRASQYREQLKVL-T------A
ENTMLTSK-----------------------------------LK-EKQDK---------
--EILETEIESHHPRLASALQDH--DQSVTSRKNQE----LAFHSAGDAPL--QGIMNVD
VSNAIYNNEVLH--------------------------Q-PLYEAQRKSKS--PKINLNY
AG-DDLRENALV-SEH--AQRDR--CETQCQMKK-----AEHMYQN-EQDNV------DK
HTEQQESLEQKLFQLESKNRWLRQQLVYAHKKV----NKSKVTINIQF----PE------
----T-KMQHHLKEK-NEEIFNYG-NHLKERIDQYEKEKAEREV--SIKKYKYFST-F--
--LK---------ENGLS------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-----------------------------

MGGKYSLERWRWPGCSGGFSVLCGKQKKSL------------------------------
---------------------------------------------------------VET
PLGF--------------CDIEAQGNNL---------------------SFGTQNPSYLD
MAYFPDND-----LHM---------------AACAGDL----------------------
PF---VRLYFTLG-KYD--VN-HRDKD------------------NRNAL----------
----------HFAC--FYGHLDMVNYLWRRGCQINV--CDKHNITPLMK-----------
-AVQSWEEEIVCYLL-ERHANLHIRDSS----GN--TAFHYAV-YGGKPAMAARLLQYGA
NIEERTKD-N---LTPLL------LALRENRLHMAQ-FLIKMEAS--------VHAV---
-DSHRR-------NS-LMYAVR--CDSS--VMVNL-------------------------
--LL-QQG-VDM--------NFKD------LFG-WTALR---YA-IE---GDR---E---
--VRTVLLDLRQNNSAPQS-----------------------------SENYSSIRPTN-
KADAGTTSSTATENMIEMQDPLTT------NEAGVK------------------K-TET-
---------CQPAE------------------------PGAE---MISLK----------
----------KE-----------------------------ISCNETIKNSQ--------
--------QSPGQLCV--QIDA-----------VTV--------NSP-------------
------------------------------------------------------------
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-----------------------------

------------------MKKIF---SKKG------------------------------
--------------------------------------------------------ESPL
GSFA----------------RRRRSSAGGGG----------------EPGEGAYAQPGYH
VRDRDLGK-----DPQ---------------------S----------------------
CQ---LQQILLLRK-NG--LN-DRDKM------------------NRTAI----------
----------HLAC--ANGHPEVVTLLVDRKCQLNV--CDNENRTALMK-----------
-AVQCQEEKCATILL-EHGADPNLADVH----GN--TALHYAV-YNEDISVATKLLLCDA
NIEAKNKD-D---LTPLL------LAVSGKKQQMVE-FLIKKKAN--------VNAV---
-DKLES-------SH-QLISEY--KEER--IPKNSSQNSNSDQSSQYGETP-N-------
---L-AIM-KHC--------YHXX------XXX-XXXXX---XX-XX---XXX---XX--
--XXXXXX----XXXXXXX-XXF-------------------------------------
LSF---------------------------------------------------------
---------------------------------------------------YF-------
-------Q----------------------------------------------------
FFCLSLPGSRDYRLSG--KPGV--------------D----D--SWPTSDD---------
--------EDLNFDTKN-------------------VPKPSLAKLMTASQQSRK---NLE
ATYGIVRT------------------GKRTLFEDRDSDSQ--------------------
---------------------D-------------------EVVV---------------
------------------------------------------------------------
-----------------------------ESLPT--------------------------
----------------------------------TSIEVQGFSHPT--YQSPDLLP-KPS
HKS---------------------------------------------------------
----------------------------------------LANP----------------
-----------------------------------GLIKEEPTKPAIEKKE---------
---NGIDIIE----SAPLE--------------QTNNDN-------------LTYVDEVH
NNN----RSDMMSALGLGQEEDIESPWDSESI-SETFPQKYVD---------------PL
AGAADRKEKNIGNE---Q------AE----------------------------------
-----------------------------------------ESPERYLHLKPT----IEM
-KDSVPNK-----------------------------AGGMK------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------DV------------------
---------------------------------------------QTSK-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------AA
EHDLEVASEEEQER-EG-------------SENNQPQVE--------EERKKHR------
---------------------------NNEMEVS---ANIPDGATDDAED----------
D--DDDDDGLIQ---------KRKSGETD----HQQFPRKENKEY---------------
---------ASSGPALQMKE-VKRTEK--EKQTSKESVNSPVFEKANLL-----------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------TGGLLQV---------
--------------------------------------------KNQIQSMD--------
------------------------------------------------------DV-DDL
TQSSETASEDCELP--HSSYKNFMLLIEQLG---ME--CKD--SVSLLKIQDA----ALS
CERLLEL---KKNH-------------------CELLTVKIKKMEDK-------------
--VNVLQ----KELSETK---EIKSQLEHQKVE-WEREL--CSLRFSLNQEEEKRRNADI
LY-EKIREQ----LRRKEEQ------------------YRKEVEVKQQLELSLQTLEMEL
RTVKSNLN-QVIQERNDAQRQLSREQNARMLQDGIL-----TNHLSK--QKEIEMAQ---
-KKMNSENSH-----SHEEEKD---LLHE------NSMLQEEIAMLRLEIDTIKNQNQEK
EKKCFEDLEIVKEKNEDLQKTIKQNEETLT--------QTISQYNGRLSVL-T------A
ENAMLNSK-----------------------------------LENEKQSK---------
--ERLEAEVESYCSRLAAAIRDR--DQSETSKRDLE----LAFQRARDECSRLQDKMNFD
VSNLKDNNEILS--------------------------Q-QLFKTESKLNS--LEIELHH
TR-DALREKTLC-LEQ--VQKDL--SQTQCQMKE-----MEQKYQN-EQVKV------NK
YIGKQESVEERLSQLQSENMLLRQQLDDAHNKA---DNKEKTVISIQD----QFHAIVQK
LQAES-EKQSLLLEERNKELISEC-NHLKERQYQYENEKAER EV--VVRQLQQELADT--
--LKKQ------SMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQ-LQEAQDRHTEAVR
C-----------------------------------AEKMQDHKQKLEKDNAKLKVTIKK
QMDKIEELQ----KNLLNA-----------------------------------------
------------------------------NLSEDEKE-QLKKL---MELKQSLECN-LD
QEMKKNVELEREITGFKNL-----LKMTR--------------KKLNE------YENG--
--EF-SFHGDLKTSQFEMGIQINKLKHKIDDLTAELETAGSKCLHLDTK-----------
-NQVL--QQELLSMKTIQKKCEKLQKNKKKLEQEVIDLRSH---IER-NMVELGQVKQY-
KQEIEERARQEI-VEKLKEVNL---FLQAQAA-SQENLEQ-LREN-NFASM KSQMELRIK
DLESEL-SKIKTSQE------DFNKTELEKYK----QLYLEELKVRKSLS-SKLNKTNER
LAEVSTKLLVEKQQ---SRSLFT------TLTTRPVMEPPCVGNLSNSLDLNRKLIPREN
LVI-STSNPRASNNS-MENYLSKMQQELEKNLTRELKEA-AAE-----LES-----G---
--------------------S-IASPLGST---------DES----NLNQDLVWKASREY
VQVLKKN--YMI------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------FRTPL----------
----------HLAC--ANGHADVVTFLVENKCKLNV--FDSDNRSPLMK-----------
-AVQCQQEKCVVILL-EHGADPNLGDAS----GN--TALHLAA-VAPNTFLAGILIEHNA
HIDAQNKD-G---CTPLT------LAVSEHHDEMVE-FLLKKGAD--------VHAR---
-DLCER-------TP-LMTAAS--GGEL--KLVKV-------------------------
--LL-RYG-ADL--------SHKD------TNG-WTAED---YA-II---HGY---VS--
--FPFRKGEEGRQNHVS-------------------------------------------
------------------------------------------------------------
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-----------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------T----------
----------AHLC--ATG-PE-MVLLVSRGCELNL--YDREGRTPLIK-----------
-AVQLRQEACATILL-QNGADPNIMDLF----GR--TALHYAV-YNEDTSMIEKLLLHGT
NIEECGKC-E---YQPLL------FAVSRRKVKMVE-FLLKNKAN--------INAI---
-DYLSR-------SA-LILAVT--LGEK--DIVILL------------------------
---L-QHN-IDV--------FSRD------AYG-KLAED---YA-LE---AKN---K---
------------------------------------------------------------
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-----------------------------

-------------------MKLFGFGSRRG------------------------------
--------------------------------------------------------QTAQ
GS----------------------------------------------ID-HVYTGSGYR
IRDSELQK-----IHR---------------AAVKGDA----------------------
AE---VERCLARRS-GE--LD-ALDKQ------------------HRTAL----------
----------HLAC--ASGHVQVVTLLVNRKCQIDV--CDKENRTPLIQ-----------
-AVHCQEEACAVILL-EHGANPNLKDIY----GN--TALHYAV-YSESTSLAEKLLSHGA
HIEALDKD-N---NTPLL------FAIICKKEKMVE-FLLKKKAS--------SHAV---
-DRLRR-------SA-LMLAVY--YDSP--GIVNI-------------------------
--LL-KQN-IDV--------FAQD------MCG-RDAED---YA-IS---HHL---TK--
--IQQQILEHKKKILKKEKSDVG-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------S--------------
----------SD--ES--A-------------------------VSIFHEL---------
------------------------------------------------------------
--------------------------------------------R---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------V----------------------------------------------------
------------DSLPASD-----------------------------------------
------------------------------------------------------------
----------------------------------------------------------DK
-DLNVATK--------------------------------------------Q-------
------------------------------------------------------------
-------------------------------------------------CV--PEKVSEP
LPGSS-------------------------------------------------------
-------------HEKGNR-------------------------------------IVNG
QGE---------------------------------------------------------
------------------------------------------------------------
-------------------GPPAKHPSLKPS-T---------------------------
---------------------------------------------------EVEDPAVKG
------------------------------------------------------------
----------------------------AV-------QRKNVQTL---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------RAEQALPVASEEEQQRHER--SEKKQPQVKEGNNTNKSEKIQL--SEN---
------------------------------------------------------------
------------ICDST-------------------------------------------
--------------------------------------------SS--------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------AAAGR-LTQQRKIGKTYPQQFPKK-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------L-----------------------------------------------------
-------------------------------------KE--EHDRCTLKQENEEKTNVNM
LY-KKNREE----LERKEKQ------------------YKKEVEAKQ-LEPTVQSLEMKS
KTARNTP-----------------------------------------------------
---------NW-DFHNHEEMK---GLMDE------NCILKADIAILRQEICTMKNDNLEK
ENKYLKDIKIVKETNAALEKYIKLNEEMIT--------ETAFRYQQELNDL-K------A
ENTRLNAE-----------------------------------LLKEKESK---------
--KRLEADIESYQSRLAAAISKH--SESVKTERNLK----LALERTQDVSV--QVEMSSA
ISKVKDENEFLT--------------------------E-QLSETQIKFNA--LKDKFRK
TR-DSLRKKSLA-LET--VQNNL--SQTQQQTQE-----MKEMYQN-AEAKV------NN
STGKWNCVEERICHLQRENAWLVQQ-LDDVHQK---EDHKEIVTNIQR----GFI-----
---ES-GKKDFVLEEKSKKLMNEC-DHLKESLFQYEREKTEVVV--SIKEDKYFQ-TS--
--RKKI------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TAL----------
----------HLAC--ASGRQEVVTLLAERKCELDI--RDGRGKTALIM-----------
-AVQCQEEKCANILL-EHGADPKAAEVS----GN--TALHYAA-HHGMISIAEKLLSLSV
NVDQIKLL----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-----------------------------

MEEEINY-------DSQTMN--I------P------------------------------
---------------------------------------------------------RRR
RWYT--------------HL--WRSCLGLRC--------------MH--PQKKKKYPLYL
IGYDPIGP-----LQR---------------AASVGDL----------------------
DT---TEKLIHSS-QHH--VD-ESDRR------------------KRTSL----------
----------HYAC--AHNHPDVVTLLLENNSSINI--RDDEGCTPLIK-----------
-ATQRDNVDCASVLL-THNADPNLIDSS----GN--TAFHHAI-SRGNIRIVKMLLEHNV
DIEAKTEY-G---LTPLQ------LATFEQKPEMVE-FLAAKCAK--------SSVT---
-PSWSP-------SP-TVSPCP--SSTS--PLSSL-------------------------
--GL-PVC-PNP--------GTSS------LSE-DRKSS---SA------RRI-------
-KL---------------------------------------------------------
STGSSAQRTEVKHVRFN-EEVLYF------KEERPLSCEARPPRQLKSILKNT------V
--------------------------------------QYNTVNEKITRRTSLW------
------CSKAEDVR------------------YTSCIKVKCYSVKSSFL-----------
------------------------------------------------------------
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-----------------------------

------------------MRKFFGFGSQKG------------------------------
--------------------------------------------------------KSSL
GSST----------------IQQGNGFDMVS----------------ESGNRVTSGPRYH
IRDKDLGK-----IHK---------------AASTGNV----------------------
QK---VQKILLLQE-NG--LN-DKDRK------------------SRTAL----------
----------HLAC--ANGHPEVVTLLADRKCQLNL--CDNENRTALIK-----------
-AVQCQEEECATILL-ERGADPNIMDID----GN--SALHYAV-AAQNMDMAAKLLSYKA
NIEARNKD-E---LTPLL------LAVTEKKQQMVE-FLVKRNAN--------VHAV---
-DKMKS-------NY-KLIHDY--KVGE--ICKQLSQNRNQASEHSE-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------GDSVRSCLI--KPDV--------------D----D--SWPESDD---------
--------DDFCFETKN-------------------VVNPSVGKIMSVVQQALK---NIE
EKYGTLRN------------------VKETSSEDDQAHRE--------------------
---------------------N-------------------EDGS---------------
------------------------------------------------------------
-----------------------------ATLPK--------------------------
----------------------------------PSTAVQVCSPHD--FP----------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------EEETKPATGNEE---------
---NGINIIE----SAPQK--------------QTNNDI-------------LICADGTH
END-----TNVMSALGLGKKEDEESPWDSESF-AASVPGNYIV---------------YL
PEAAEESGKNIPNG---Q------VEA---------------------------------
------------------------------------------------------------
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ELVLGLTSEEKQESLRG-------------SEKN--------------------------
------------------------------------------------------------
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-------H-PVIEERNDSQRQLSQELNARMSQDTIP-----TNHLCK--QK-IEINL---
-KEMNSEISE-----SHKKEKR---LLHK------NHMLQDEIAMLRLETDTVKNQKQEM
EKKYL-DIATVQDKNDCHQKTIKLNEETLT--------KKIFQCTAQLNIL-T------A
ENTMLKYQ-----------------------------------LEDEKENK---------
--ERLETEVESYCSRLATATHDH--EQGQTSKKDLE----LSFQRARDEWFHLRDKMNFD
LYNLKGNNEILS--------------------------Q-QLCKAESKLNS--LETELHQ
IR-DALRERTLV-LEH--VQTDL--SQTQCQKKE-----IEYKYQH-EQDKV------NK
CTGKQKSLEERLSQLQSENALLRQQPDHADHKG---DSQERAVINMQE----QFQDVIKR
LKAES-EKQGHILQEKNQKLINEC-NRLKERVCR-ELDKEEREV--VVRQLQQELADT--
--LRKQ------SMSEVSLEVTAHYHTNLGDETHDVKMKLDQIRS--VQEARDEHVKAIK
C-----------------------------------AEKMQDQMRKLETECAELKDTIKK
QASRSEQLQ----RNLLGT-----------------------------------------
------------------------------SLSENEKE----------LLKQSLEYR-LD
EEKRKNDELEKEITRLKEL-----LKITR--------------RKLNE------YEKG--
--EL-HLPGDLKPNLTEMDVPITKLKQKITDSKAKLETVSSKCLRLEEE-----------
-NQFL--RQQLLSLKGIQAKCDELKNKNKNLEGKLVILQNH---IEM-NMVEYNEVEQY-
KHETEERGRQEI---------L---FLQAQAA-SQENLPH-F-EN-DNASIRSHRELRIE
DLESEL-SQVKASQV------DSNKTDLEKYK----QLYLEELQVRT-----KLNKANER
LAETRTEFRAMEQQ---YKSLLS------ILNTRPVREPPCPAT--QSFMLNRNPAQREN
SEI-STSIPWTSNNS-METYLFKMQRELEKNILRELNEA-EAE-----LEF-----E---
--------------------SCRLSSLVSI---------DDL----SLYQNLVLKMSQKY
VQILKKN--MI-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------MKRLSAACVKGE------------------------------
--------------------------------------------------------TGPE
RPSP-------------------------------------------FSQLVYTKNDSYV
IHHGDLRK-----IHK---------------AASQGQA----------------------
WK---LERM-MKKTTMDLN---IKDAK------------------KRTAL----------
----------HWAC--FNGHAEVVTLLVDRKCQLDV--LDGENRTPLMK-----------
-ALQCQREACANILI-DSGADPNIVDVY----GN--TAVHYAV-YSENLSVVVKLLSCGA
DIEVKNKA-G---HTPLL------LAIRKRSEQIVE-FLLTKNAN--------ANAV---
-DKFKC------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------I--H-------------------------QQLLEYKQ--------
-----------K------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--ISKNSQ-------------------------------------------NS-------
------------------------------------------------------------
-------------------------------------------------NP---EGTSEG
TPEEA-------------------------------------------------------
-------------TPLAER-------------------------------------T-PG
KAE---------------------------------------------------------
------------------------------------------------------------
-------------------GSV--EGTPDE------------------------------
------------------------------------------------------------
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-----------------------------

------------------MKKIFNFCKKDQ------------------------------
--------------------------------------------------------SPSS
P-SI--------------KLPSYFA------------------------VGTPDLTPGYL
IQDKDLGK-----LHK---------------AASIGDV----------------------
AK---MQQLLLLGK-NN--VN-DLDKV------------------KRTPL----------
----------HLAC--AKGYPDIVSLLVERKCKVDL--QDKDSLTPLIK-----------
-AVLCHQEECATILL-KHGADPNLGDHN----NN--TALHYAA-FDQNVAMAEKLLTYKA
DIEAKNKE-G---FTPFM------FAVMKRSYELVE-LLLKMGAN--------VNAT---
-DNTKR-------TS-LMIAIS--MESM--GIVNL-------------------------
--LF-QNN-VDT--------TCED------EDG-WTAEK---YA-KH---FRY---PL--
--HIYHSLIDEQKLQKELYQPCS-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------P--------------
----------QI--SC--S-------------------------EKTSGIRF--------
-----------G------------------------------------------------
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--LGGSAL-------------------------------------------DK-------
------------------------------------------------------------
-------------------------------------------------EG--RTDKPK-
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-----------------------------

------------------------------------------------------------
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-----MEILIMLG-QCS--VF-DRDHK------------------NRTAL----------
----------HFAC--VYGRLPVVNILLKNNCEIDA--FDQRQITPLMK-----------
-SVQCWKQKCAAVLL-EHGADPNIRDSS----GN--CALHYAV-YNGHEDMAALLLEYHA
DIEQKTKD-G---FTPLL------LALREKRVEVAE-FLVIKGAD--------IHVV---
-DDMQR-------NT-LMYAIR--CGSK--DIAML-------------------------
--LL-QKG-IDF--------FYKD------VFG-WTALR---YA-VE---GRC---T---
--FRQMLLDFEENIHNNKKDNEPGKSYNEL------------------------------
------------------LFAQGI------SESAPLSCTGSLSLAIDKIFENSARRKVTE
S------VATEVRE----------SVATEARE-----SVTNEAAERTELLPFL-------
-------PELEL-----------------------------ISVEEDIPDESADNQIHPL
LTLEHLPQKNVGHLSG--TGHQ-----------MGNI---NI--SGQMKESD--EEHS--
-----------QLTTPI------------------EIKDDDFKEA-WATKNTP-------
-------------AFKSEPDLEVTSEEDHSRFDER-----GS------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------IHSLSIYENLPNMS-------------------------------------
------------------------------------------------------------
-----------------------------------GNEFVGADSR---REKTNGQATEPG
EEYPPLMVIA-FMFS-------------LW------------------------IIYLSE
-GPA--------VKLTSEE----ES--DSYDG-FEKNPPLTIFNQIHTQDVGYLSM----
---AKEQRGEKMVMCQ---------------EKEF--SKECP--QSKPTIVEQESVPKEA
WDMSPVIQLLADTP-----------------KDY-------------PLSETT----VEE
-NDSVPNE-----------------------------VCDTKHGKWFLVGELIILIFM--
NER-----YEGTR-----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------HDEDPT------------------------------------------------
------------------------------------------------TAITCLVLKP-V
QMKTPLPCKAPAR---KEVKAFGPESDAYS------------------------------
---SSEGEQECPDDNE-GEHLKQPQPMGTAH-SSMAE-----------------------
----------------------DERGVNAV-------------SDQEK------------
-----DLVIMEDSTMK--------QEKSLTAGVS--------------------------
-------------------------------------------TA-------QLRPKKEQ
TGRFGSDKKQRKPIFERLQSKWRAQMSADPEE-SRENTGAAEGKVRAA---------TRW
--------------MEHDVGRYELGFISLFQCL------------------T---THMYF
LGATTVQLR-PEEEQTKRNGCDKK-------------------QRKP-IFERFQ------
--PKWSARVSVGPEESREN----------TGATGEKGKDPINR-------RYCRECSEIK
QEVGNKSPKLFTSEEQTGCHDSEK-K-PQLHILE-------------RFQPKWSVRV---
----------------CV---------ETK----------E-GENAE----------A-T
D----MTCSSDEYTE------------LKATTEKQDSVPTEDPIM-EQER----------
SSMAEP-DSSAKSK---EMQRSPSYDNSQSTGIDHL-------SMTVGQRSKD-ILSEE-
---------EEEPDLEAASGDEQNKRYS--SESNQSL--------VEKT-KMCASNGID-
------IAKYPCEAAVF----------TSPAAGGG--GDISAAAAAAGGG----------
---DAAGDD--AAVSGGD-AAAVSGGD-------AAA-------V----------SGG-D
AAADGDTAAAAIS------------------GDAAAAADGGGGTDAAAGG----------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------I---ADSTMDK-LVLQRKSGEINDQRFLIK-
---------------------ENAKH-DGPRKKTSKGKHK---TLID-------------
-----------------------------------------------------------V
FYFV-------------------------SS---FL--HPD--SGGSLKIQDS----PNS
YNALLDL---KKIH-------------------ELL-RKKHQKIENK-------------
--IIALR----KELTERR---EEKSKLEDEIVE-QDEEF--WTLRFTLCKEFKETRIIH-
---KNIKKH----LHEKQKQ------------------FNERVTMAE-LESHLRTRDMEL
RSAKTILK-ELQE-----------------------------------------------
---------------SQRQHIE---TLKI------AQKMKDHLQRIEQEHSELKVEVKEQ
AKKI-EE----------LRGCLQNSPLKLE----------QNEKLTQAG-----------
----TQET-----------------------------------LEELCENI--------S
LMGQTGIRIQSLRSESSKTKTGK--DSNTSAQKSYE---------------------QQC
IEELRISNALLYN---FYRNRRRDKSLKQVHITVEQDTS-PLPTPETRFSLENPCVASSC
SRRHLFPCGNMV-LPG--NPRSSDDSILYDF-LK-----MEDEE-----KSI------KV
LTKLKQSLEYNLYQQQKKNDELAKEIT-----------------------------RNKK
LL-KM-AKIGH-------EIGECS-YHGNSKSDHF-------------------------
------------------------------------------------------------
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-----------------------------

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----------------Q----TISQEPDV-KDCDTEN-V----------------SI-HW
ELSCMQTYAETWVQGGKLEEENGSEF---------------------N------------
------ICEQYRG-----------------------------------------------
----TWPEEEPLHDHSRGRANLTGIPSTLTS-H-------------------------IL
DCEEKDASGASACVVVPTVPKQIEPHLQHVFP-----------CHSCSVSPECACQSSSQ
LSLSENKSFFENDNKPDTDNVFNTDEENFYSDTGNKKAR-ESEVVTVEMKD-----G---
QEF-NKQMIR--------------------------------------------------
----------------NMK-NPLCDKGNAKNYENVR-PK-C--EN-VSSSPHSNRTSKVS
LKEKLQ---QDVQKFKNEVSMLQAEF-----LAVEKEKIQLKNEVEEERKKQ---KSNEI
KVSG-----------ILYDGGSDDSDNEP-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------INTNL-LE------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------KQNEAKK---KKPAKKTPKEKNK---VEQNIHSMG--------
------------------------------------------------------DL-DDL
TGSSSIAPEDCELP--HSDF---MLLIEQLG---KD--CK--DSVSLMKMRDE----FVS
HQRLLEL---TENH-------------------CEQLIAQIEKMENK-------------
--ADVLQ----KQLWKTE---DINLQLEHLKVA-REHEL--CTVRFTSKEEEEKRRNFSI
LC-EQIREE----LRRKEEE------------------CRKEVEMKQQREQTLKKQNEEF
WTMRTYLS-EVLQKQNDTQRKLYGEHNSRLFQFQTI-----LSKERN--LKDFI------
-----KFHLSK-YIHGQEKEKY---LLHK------NSMLQEEISKLRIEIATMKNQKQEN
EKKYLKDLEIAKEKNDDLAMSLKLNVDKLI--------KARSQYAGQFYVL-EA------
ENTILNHK-----------------------------------LEEETHSK---------
--ERLEREVASSCSRLSAVTRDL--DESETSKRHLE----LALKRVRDEWFYSKGKMDLN
VSNLIEESEILS--------------------------Q-KLSNVESKIGS--LETELHD
TT-ADLIEKTLF-VEG--LYREL--IQKYCQMNK-----MEQPYEN-EESKL------NQ
CISKRESLEESLCQPLRESMLLCQQLDAAHSKA---DHKDLAVMNIQD----QFQETVIN
LPTES-EEQILLLGGKLQKLIKTF-TYLKEIIYHCERDNAERET--N-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------ELTEALETSSLQHHHVGAM-----------
-NQVP--PQELLSMETIQTRCLELQNINQKLKEAVVYLKNH---MER-NMIDCGQLEQY-
KWEIEARARQTI-GEKLKEVIL---FLQTQAA-SQEL-----RKD-HVASVKSQLEVQIK
DLESVL-SKMTMS-QDF------SNIELEKYK----IFCQVEIESKNFLS-YKYNR----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----MRRFF----------G-LGGKQ------------------GKTAL----------
----------HLAC--ASGRQEVVTLLAERKCELDI--RDGRGKTALIM-----------
-AVQCQKEKCANILL-EHGADPKAADVN----GN--TALYYTA-HHGMIPIAEKLLSLNV
NVDVKSKH-E---MTPLL------IAVNADEQRMVE-FLLNKKAN--------IYAV---
-DEKKS-------NS-ELLSKS--VEKYK-------------------------------
--MS-QNN-AXX--------X----------------------X-XX---X---------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------X---------------------
------------------------------------------XXXXX--XXXX-------
-XXDKSSGDSIKSISK--K---------------SKS---D---EQPASGD----DVL--
-----------GLNTKE-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------GTRIPTIVEK------E---
---NGINVIE----EQRKKDD---D-----------------------------------
------------------------------------------------------------
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-----------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TPL----------
----------HLAC--AHGYPDVVSLLIEKKCKLNP--CDNEYQTPLMK-----------
-AIQCQQEECAAILL-EHGADPGVIDTY----HN--TALHYAA-CAHNTKIAARLFRYNV
EMEAKNKV-E--------------------------------------------------
------------------------------------------------------------
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-----------------------------

------------------MKRIF---SKKG------------------------------
--------------------------------------------------------DSPL
GSFA----------------RRRRSNSGGGG----------------EPGDGAYSQPGYP
VRDRDLGK-----IHK---------------AASAGNV----------------------
AK---VQQILLLRK-NG--LN-DRDKM------------------NRTAL----------
----------HLAC--ASGHPEVVTLLVDRKCQLNV--CDNENRTALMK-----------
-AVQCQEEECATILL-EHGADPNLADVH----GN--TALHYAV-YNEDMSVATKLLLHDA
NIEARNKD-D---LTPLL------LAVSGKKQQMVE-FLIKKKAN--------ASGV---
-DRLES-------SH-HLISEC--KEER--IPKNSSQNSDSVDESSEDSLTTVPGLWFIY
FFVY-FET-ASC--------SVTQ------AG----------------------------
------LQ----WRSLSSL-QPL-------------------------------------
PPE---------------------------------------------------------
---------------------------------------------------FK-------
-------Q----------------------------------------------------
FSCSSILSSWDYRLSG--KPGI--------------D----D--SWPTSDD---------
--------EDVNFDTKN-------------------VPKPSLAKLMTASQQSKK---NLE
ATYGIVRT------------------GNRTSFEDRDSDSQ--------------------
---------------------D-------------------EVVI---------------
------------------------------------------------------------
-----------------------------ESLPT--------------------------
----------------------------------TSIQVQGFSHPT--YPSPDPLP-KPF
HKS---------------------------------------------------------
----------------------------------------LANP----------------
-----------------------------------GLTEV--------------------
------------------------------------------------------------
--------SYMMSALGLGQEEDIESPWDSESI-SENFPQKYVD---------------PL
AGAADRKEKNIGNE---Q------AE----------------------------------
-----------------------------------------ESPERYRHLKPT----IEM
-QDSVPNK-----------------------------AGGMK------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------NV------------------
---------------------------------------------QTSK-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------AA
EHDLEVTSEEEQER-KG-------------SENKQSQVE--------EERKKYR------
---------------------------NNEMEVS---ANIYDSATDDEDD----------
ED-VDDDDRLIQ---------ERRSGKTD----HQQFPRKENKEY---------------
---------VSSGPALQMKE-VKKG-----KPTSKESVNSLVFEKASLL-----------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------TGGLLQV---------
--------------------------------------------KNQIQSMD--------
------------------------------------------------------DV-DDL
TQSSETASEDCELP--HSNYKNFMLLIEQLG---ME--CKD--SVTLLKIHDA----ALS
CERLLEL---KKNH-------------------CELLRVKTKKMEDK-------------
--VNVLQ----KELSETK---EIKSQLEHQKVE-WEREL--CSLRFSLNQEEEKRRNADM
LY-EKIREQ----LRGKEEQ------------------YRKEVEVKQQLELTLQTLEMEL
RTVKSNLN-QVVQERNDTQRQLSREQNARVLQDGIL-----TNHLSK--QKEIEMTQ---
-KKMNSENSH-----SHEEEKD---LLHK------NSVLQEEIAMLRLEIDTIKNQNQEK
EKKCFEDIEIAKEKNEDLQKTIKQNEETLT--------QTISQYNGRLNVL-T------A
ENAMLNSK-----------------------------------LENEKQSK---------
--DRLETEVESYRARLAAAIHDR--DQSETSKRDLE----LAFQRARDEWSRLQDRMNFD
VSNLKDNNEILS--------------------------Q-QLSKTESKLNS--LEIELHH
AR-NALREKTLG-LER--VQTDL--SQTQCQMKE-----MEQKYQN-EQVKV------NK
YIGKQESVEERLSQLQSENMLLQQQLEDAHNKA---DNKEKTVINIQE----QFHAIVQK
LQAES-EKQSLLLEERNKELISEC-NHLKERQYQYENEKAER EV--FVRQLQQELADT--
--LKKQ------SMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQ-LQEAQEQHTEAVR
C-----------------------------------VEKMQDHKQKLEKDNAKLKVTIKK
QMDKIEELQ----KNLLNA-----------------------------------------
------------------------------NLVIQDHLGQHSKT---LSLKKCKTD----
-----ELDQLTGHCKFKNL-----LKMTR--------------KKLNE------YENG--
--EF-NFHGDLKTSPFEMDIQINKLKHKA-------------------------------
------------------------------------------------------------
-----------------------------QAA-SQENLEQ-LREN-NFASM KSQMELRIK
DLESEL-SKMKTSQE------DFNKTELEKYK----QLYLEELKVRKSLS-KKLNKTNER
LAEVNTKLLVEKQQ---TRSLFT------TLTTRPVLEFPCVRNLNDSLDLNRKLIPREN
LLI-STSNPRTSNNS-MEKYLTKMQQELEKNITRELEGV-AAE-----LES-----G---
--------------------S-VSSPLGST---------AES----ILNQDLVWKASREY
VQVLKKN--YMI------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------MKAVQCQ---EEE---CA------------------------
------------------------------------------------------T-----
------------------IL--LKHGS-------------DTS----ITDNEGNTALHYA
VSEENVSIAKKLVLHKADIEAKNKDGFTPLLIAVKNDK----------------------
RK---MVAFLVEEG-AN--VN-AVDNA------------------KRSAL----------
----------HLAC--AKGHVYIVHILMYLECELNL--RDEENRTALMK-----------
-AAQFQHVECATIVLG-QGAD--PNIKDDE--GN--TALHYSV-FEENISIAKQLLLHKA
DIEVKNKD-G---LTPVL------IALKANKEQMVN-FLVGKGAS--------LPAG---
-DKVKS-------ND-QLISEH--EEEM----KPENSSEN--------------------
---------HDL--------VAEK------SE----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------EDSISSLSD--KADI------------------DN--SWPSSIEDL-------
---------GPPTKT-------VPELNL--------------RELMAA------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------FLQARGADYGILSK
ECRLIFADN-------------FASEDKTETLLKPSVNVSDYSPLA--FVSPET-P----
QTSL--------------------------------------------------------
------------------------------------------------------------
--------------------------------AMRDVTKEGAMKPAIGKKD---------
---NGIDIIE----SASQEQA--------------VNDNLT-------------SADRAH
KNN----TSDRMSALG-EED---SSPWDSESI-SVRLPKKSVD--C-------------L
PGAA--------------------------------------------------DQ----
------------------------------------------------------------
-------------------------------------------QG-----QSIFNEQV--
ED---SPGK------DL---HWE-STTKVKDS------VPNEGVATSDKQTSISDLS---
--------------SEPDLE-------------------VASEQE----------QEQER
-PDES-----------ENNHPQDKVIS---------------QTCMLA------EK-TSE
S---QTKQINVPLVQLQ----DMAREPEMHMECDRQDGR----------------SVHSE
HLRAHKKYEEIWMKQGKLDWKNNVKL-----------MSRELTQEIGK------------
------TCEKYQII----------------------------------------------
----THPKVEPLHGNS-KEADLKEIPPKLTK-V-------------------------TL
DYEEKDEFGVSVSVVPQAFPERKEPSLENAVL-----------SHSYSGSPDYACQSSSK
LSFHEN------DNQPGE-HVFNKNES-LDNDTEDKKV--RNPLVTFEVKE-----D---
QEF-DLQMAKSLNQNTTNSKLDTG----YIPPYSDPESLFDLQLAHSNVVKQMIQKKRHD
TSAITNTYKKTKPIRDSFQKPLYADNDSTNNYKSTE-PA-L--EV-VSSSPRPFRTSEVH
QKEELQQDKQDLQRFRNEKGMLQVEL-----LASEKEKVELQKESGKERKKH---KSSKM
EGAE-----------KIYAAAAAPAPAAAPA-A---A---PAAAASPPVAPAAPPAAPPA
AAPAAAAPPVAPPAPAAPPVAPPAALAAPRAPAAPRAAPAPHAAPAPAAAPPPAAPRAAA
APPAAPAAAP--AARPPAAPRAAA--AP-----PAAALAPAAA--AAPPAAPRAVAASRA
APAAPRATPAAPPAVPCAAAAPPAAPAAAAPPAAAPAAPCAAAAPRAAPAAAPLAAAHPA
AVAPPAAAAPPAAPAA--LATAAAAA--PPAAPPPPPVAAPAAGL-IQQR----------
--KSGK------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------TDNHLFPTMQNEDS---------------
-------DS--NDPGLSIME-IKKDKNV--KWTSKASMITPGF-----------EK----
----------------------ADFLTGSLL-----------------------------
-----------------------------------RV--SNDN----N------------
------------------------------------------------------------
----------------LSEMDQDE---RRPAKKTSKEKNK---SHRERERQRHRQRE---
-KQAPCTG----SPMWDSIPGLQDRALGQRQ-VPNHCATQGSLIKVKKQVNSVEHL-DDL
TQSSEAASEHCKLQ--YSDYKSSLLPIGQLG---MD--CK--DSVSVLTTQDA----IFK
YKRLIEL---KTKD-------------------CEQLTRKILKMEYK-------------
--VNVLQ----EELSEAK---EMKSQVERQKVE-LEREL--YSLREQ-------------
-------------LRSKEEQ------------------HSKEVEMKQQLNLRRG--NLEL
KSVK--------------------------------------------------------
------SNLSQ-VSPPHEKEKG---LLHE------NRRLQDEIATLRLEIDTIRNQKQEK
EKKYCEDTEIEKEKNDSLQIVIKLNGVTLT--------NTVFQSSGQLNVV-TT------
ENTMLNSK-----------------------------------LQNEKLNR---------
--ERPEAKLQSYRARLTTAVQDH--DQSQASKRDLE----LAFQRTKDEWCHLQGKMNFE
MSNLKDNNEVLS--------------------------Q-QFSEAKSKFNT--LEIELQY
KR-DALREKTLA-LEH--VQRNL--KQTQDQKME-----IEQKSQN-EQDKV------NK
YMGKHESLEERLSQPQSENTLLREQLDDGYSRV---ECKEKTRIDLED----QVHVTVRN
LQAEL-ENQGLI-QQGDTEFIDEW-EHLIERRYTYKKEKEGREV--VMRE-QQELSNT--
--LKEQ------SMSQASLE-LPHYYTKLEDEIQDLKKTGNQIKSQ-VQEVEDQHAKILR
CTEK-----------------------------------SGDHQKKIEVENATLKVTIKE
QAGQIEQLQ----KDPLRSSSCG-------------------------------------
-------------------------------DE---KE-NLKKC---MELKQSLPFR-LD
QEAKKNEELEKENTGMECS----EDICE--------------------------------
---V-HFVQCVIQSPCAL------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

MGGECSRGGGWRPWGSQGVSVLCCCPEKSL------------------------------
---------------------------------------------------------EET
PLGF--------------CNISGRRNTP---------------------CLGPQDPVYLD
MAYFPDND-----LHM---------------AACAGDL----------------------
PF---VRLYFTLG-KYE--VN-HRDKE------------------NRNAL----------
----------HFAS--FYGHLELVTYLWRRGCEING--CDNRNITPLMK-----------
------------------------------------------------------------
-------D-N---LTPLL------LALRENRLNMAQ-FLVSTGAS--------VHAV---
-DPQRR-------NS-LMYAVR--CDSP--VMVNL-------------------------
--LL-QQG-VDI--------NFKD------LFG-WTALR---YA-IE---GDR---E---
--V---------------------------------------------------------
------------------------------------------------------------
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-----------------------------

------------------------------------------------------------
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------------------------------------------------------------
-----------------------------------------------TAL----------
----------HLAC--SSGKSSVVTLLIQWKCDLNA--RDEEGKTALMK-----------
-AVECQEEVCVTILL-KRGADPNLKDNC----QN--TALHYAV-LAENTSIAAKLLRYNA
DIEAINEY-K---YTPLL------LAIRENKEEMVK-FLIENGAN--------VHAV---
-DKLQS-------LY-QLIVDY--RARR--IPNTPPQNSDLGGTSLKITLAER----TGA
E-----------------------------------------------------------
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-----------------------------

--------------------------MFDD------------------------------
--------------------------------------------------------YEPE
RWPT--------------LR--------------------------ERLCSDGFSFPEYR
IKLSHLRR-----IHR---------------AIFYGRL----------------------
EK---LEYLLLTRS--D--VNKR-DKK------------------ERTPL----------
----------HLAC--ATGQPDMVSLLVSARCELNL--YDRECRTPLIK-----------
-AVQLRQEVCATILL-KNGADPNIMDFF----GR--TALHYAV-YNEDTSMIETLLFYGT
DIEECSKY-E---YQPLL------LAVSRAKVNMVE-FLLKKNAN--------VNAV---
-DFLNR-------SA-LILAVT--LGEK--DIVILLL-----------------------
---K-QHN-IDV--------FSRD------AYG-KTAED---YA-IE---THN---KV--
--IFRLISEYKREKTSEELPINS-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------N--------------
----------PV--SS--Q-------------------------KQP-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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--------------------------------------------------------ALKV
ITHSF-------------------------------------------------------
-------------MF---------------------------------------------
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-----------------------------

MVA-----EVGSMPAASSVKKPFGFRSTMAKWC---------------------------
----------CHCLPCRRGSGKSNVVASGDQDNSAVKTFRSKMAKWCCHCFPCRRGSGKS
NLGASGDQDDSAVKTVRS-----------------SKSNVGAWEEYDD---SAFMEPRYH
VRREDLDK-----LHR---------------AAWWGKV----------------------
PR---KDLIVMLRD-TD--VN-KMDKQK------------------RTAL----------
----------HLAS--ANGNSEVVKLLLDRQCQLNV--LDNKNRTALTE-----------
-AVQCQDDECALMLL-EHGTDPNIPDEY----GN--TALHYAI-YNEDKLMAKALLLHGA
AIESKNKH-D---LTPLL------LGVHEQKQQVVK-FLIKKKAN--------LNAF---
-DRYGR-------TA-LILAVC--CGS-A-SLVSL-------------------------
--LL-EQN-IDV--------SSQD------LSG-QTARE---YA-VS---SHH---NV--
--ICQLFSDYKEKRMLKISSEN--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------SNPGK-----------
---------EAEEE----------------------------------------------
------------------------------------------------------------
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-----------------------------

------------------MKRFFAAAVKGE------------------------------
--------------------------------------------------------TGPE
RPSP-------------------------------------------FSQLVYTSNDSYV
IHHGDLRK-----IHK---------------AASQGQA----------------------
WK---LERM-MKKMTMDLN---IRDAK------------------KRTAL----------
----------HWAC--ANGHAEVVTLLVDRKCQLDV--LDGENRTPLMK-----------
-ALQCQREACANILI-DSGADPNIVDVY----GN--TAVHYAV-YSENLSVVVKLLSCGA
DIEVKNKA-G---TTPLL------LAIREKNNFIYF-IF---------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------IH--SI--H-------------------------QQLLEYKQ--------
-----------K------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--ISKNSQ-------------------------------------------NS-------
------------------------------------------------------------
-------------------------------------------------NP---EGTSEG
TPEEA-------------------------------------------------------
-------------ASLPER-------------------------------------T-PD
KAE---------------------------------------------------------
------------------------------------------------------------
-------------------CSV--ERTPDE------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-----------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------RTAL----------
----------HWAC--VNGHAEVVTFLVDRKCQLDV--LDGENRTPLMK-----------
-ALQCQREDCANILV-DSGAGLNIVDVY----GN--TALHYAV-YNKNLSVVAKLLSHGA
VVETQNKA-S---LTPLL------LAITKRSEQIVE-FLLTKNAN--------ANAV---
-NRFKC-------TA-LMLAVC--HGSS--EIVGMLLLRN--------------------
---------VDV--------FAED------TCG-MTAVR---YA----------------
--------------------IAC-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------G--------------
----------FD--HI--H-------------------------QQLLEYIR--------
-----------K------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--LSKNA-----------------------------------------------------
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-----------------------------

------------------MKRIFGFGS-KG------------------------------
--------------------------------------------------------RSPL
GSSSN-------------L---RRNCVGFGL----------------ENA-SRLNSPRYH
IRDKDTGK-----IHK---------------AASMGNV----------------------
AK---VQHLLILGE-NG--VN-DKDKK------------------NRTAL----------
----------HFAC--AYGHPEVVTLLVERKCNIDI--CDSDGSTALIK-----------
-AVQCQEEECATILL-EHGADTNVMDSS----GN--TALHYAV-YIENTSIAVKLLLHNA
NTEAKNKD-G---HTPLL------LALRENKQQMAE-VLVNKKAN--------VHAV---
-DELER----------QVIFEY--EEKR---LK-HSQI----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------NNSGKLSN--KPGP--------------G----D--PWPTSDE---------
--------EDSNFDTKN-------------------FPKVNLTELWTTTQQFKKN-----
QKYDILKP------------------ENRTLFDSSDSDSQ--------------------
---------------------N-------------------EDMD---------------
------------------------------------------------------------
-----------------------------ETLPK--------------------------
----------------------------------TSVKQ-SFSGPS--ILSSDP------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------NEGATKPIIGKEE---------
---NGTKS-------ASQD--------------QTNNGN-------------LTYVDAGH
KKS----KSDLMSALGLGEE-E-ESPWDSESI-SESLPQKGVS---------------HL
SGAVHERGNN-ING---Q------VED----------------------------MIYIP
SCMSGSRNFKMAKLEKTRNV--------------GIPVANMGMENNEYFYELL----FY-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------KY---------------
---------ISKLIISENFL-LRKNEN--EKYTSKESVTTPAFEMADSL-----------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------TGGLLQAPQ-------
----------------------------------------------KINAMD--------
------------------------------------------------------DL-DDL
TQSSETASEDYELL--YPSYENMLLLIEQLR---ME--CKD--SVSLLKLWDA----VHS
YKRLIEL---KKSH-------------------CELLTGKIKKMENK-------------
--VHELQ----KELSSTK---EVKSQLEHEKVE-WEGEI--HNLRFALKEEKEKRRNADN
AY-EKIKQH----LRKKEEQ------------------YNKEVEVKQQLEISLRTLEVEL
KTIKINLN-QVLEDRNDLQRQLTQEQNARILQDGIL-----ANHLCK--QKEIETAQ---
-MKMSSEVSI-----SHEKEKD---LLHK------SHSLQKEISMIRLEIDTIKNQNQEK
EKKYLEDVEIANEKNDNLQKTIKLNEETFT--------TTVLQYNGQLSIL-T------A
QNTMLNSK-----------------------------------LENEKQNK---------
--ERLEIEVESYRSRLAAAIHDY--DESQASKRDLE----LAFQRSRDECFRLQDKMNFS
ISNLKDNNEILS--------------------------Q-QLSKAERKFNS--LEIELHH
TK-DALREKTLV-LEQ--VQRDL--NQTQGQMKE-----IECMYQN-EQGKV------NK
YVGKQESLEERLSQLQSENTLLRQQLDDAQNKA---DNKEKTVINIQD----QFHDIVKK
LQAES-EKQNLMLEDRNKELINEY-NHLKERLYQYENEKAER EV--IVRQLQQELADT--
--LKKQ------SMSEASLEVSSRYRISLEDETQDLKKKLAQIRSQ-LQEAEDQHTEAAQ
C-----------------------------------VEKMQDHLQKLEIQNSKLKDTIKK
QTGKIEQLQ----KNLLSA-----------------------------------------
------------------------------NLSEDDKE-QLKKL---TELKQSLEYT-LD
QEKKKNDKLEKELTGFKKL-----LKMTK--------------TKLNK------YENG--
--EF-SFHEDLKNSSFEMDIPINMLIYKIDDLAAKLETASSKCLHLDKK-----------
-NQFL--HQELLSMKTMQKKCEKLEKNKKKLEQEVVNLKSH---IEKKNMEEHGQLEQY-
KQEIEDRARQDL-VEKLKQVNL---FLKTQAA-SQENLEQ-LRES-NNASI RSQMELRIK
DLEYEL-SKMKT-QE------DSNKIELEKYK----QLYVEEFKIRKSLL-NKLNKANER
LQDVNTQLLVEK-Q---NRSLLS------TVSPRPVVECSCVGSLNNSLVLNRSYFPREN
LVV-PTSNPKPSNKS-MENYLAEMQQKLEKSITRELKEV-ADE-----LES-----G---
--------------------SLRASPLGST---------HKS------SQDLLSEASQEY
VEILKKK--YMI------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------MKRIFGLSP-KG------------------------------
--------------------------------------------------------QAPP
SPAGL-----------------RRS----------------------------SRGARYR
VFDRSVRK-----LHK---------------AASEGDV----------------------
AR---VQHLLLLGK-SG--LN-DRDEK------------------HRTAL----------
----------HFAC--AYGHTGVVTLLVERRCDIDA--CDNENNTALIK-----------
-AVQCDQEECAAILL-EHGADPNVANAK----GN--TALHCAI-YSESASIAAKLLSHNA
DTEVKNKD-G---LTPLL------LALRENRREVAE-LFQKKKAS--------IAVM---
-DKPQR-------YSHLQIFEY--EEKR---LK-NSENSYPVDENSED------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------DSLTRSSN--KSGP--------------D----D--SWPTSDD---------
--------DDYLFDNKN-------------------APKMNLTDLWTASQQSRKN----E
AKYGIAET------------------GNRTLIDNSISDTK--------------------
---------------------N-------------------KDVV---------------
------------------------------------------------------------
-----------------------------ETLFK--------------------------
----------------------------------TSVNVQDFEK----------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------ATGPAIRKEG---------
---NGTFVVE----SASQE---------------QTNDN-------------VTNVDEEQ
KNY----KSDMMFALGLGED-D-ESPWDSESI-SENLPQKSVD---------------HL
SGAADEKGKHAGSR---Q------IED----------------------------VVYVP
SCMSGSRNFKMAKLEDSGNV--------------VIPVAHKDILLDG-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------CQNSQD------
---------------------------------------Q---VEKKISAVD--------
------------------------------------------------------DL-DDL
SQSSETPSEANELP--YPKYENILLLFEQLR---ME--CKD--SISVLKIWDA----IHS
YKTVIEL---KKDH-------------------DELLTGKIKKLENK-------------
--LRGLE----KELTETK---ELKSQLEHEKIQ-REREL--GNLRFALKQEQEKRKNVDQ
FY-ERIKEQ----LRKKEEE------------------YYQEVEAKQQLEISLRTQDMEL
KTIRTKLN-QVLEEQNDTQRQLSREQNARMLQEKIL-----ANQLSE--QKEIEMAK---
-EKMSPEVSV-----CHE--ED---LLHK------NHRLQDEIAMIRLEIDAIKNLSQEK
EKKYLEDIEIANEKTGDLQRTIKLNEETFT--------KTIFQYNGQLNSL-T------V
ENTMLNSK-----------------------------------LENEKQNK---------
--ERLTTEIESYRSRLAAAVHDY--DESQSTKRDLE----LAFQRARDEWFRLQDKMNCD
ITNLKDNNEILS--------------------------H-HLSKAERKLNS--LEIELHH
TR-DALREKTSL-LEQ--VQRDL--NQTQCQMKE-----LKHMYED-EQGKV------SK
YMGKQESMEERLSQLQSENTLLQQQLDDAHNKV---DCKEKRVVNIQD----QFHDIVKT
LQGES-EKQSLMLEDRIKELIHEC-NHLKERLYQYEKEKEER EV--VVRQLQQELADT--
--LKKQ------SMSEASLEVSSRYRINLEEETQELKKKLDQTRSQ-LEEVQDRHAEAVR
H-----------------------------------AEKMQERLQKYDLKQYTKHLGIYK
V------------HEQENV-----------------------------------------
------------------------------GCSEDDKE-QLKKL---TDLKQSLEYT-LD
QEKKKNIELNKELTGFKKL-----FKMTE--------------TKLNE------QENG--
--EF-CFHGDLKSSDYEMNIPINTLIHKIDDLAAKLETTSSKCLHLDKN-----------
-NQFL--NQELLSMKNIQKKCETLEKNKKKLEQEVVNLKSY---IEQ-NVVEHGHLEQY-
KQEIEERARRDL-VEKLKQVNL---FLQTQAA-SQEHLEQ-LRES-NNASM RNQMELRIK
DLESEL-CKTKT-QE------DSNKIQLEKYK----QLYIEEFRTRKSLS-SRLNKANEK
LEEANTKLLVEKQQ---SRSLLN------TVSTRPVLECPCVGNFNHSLGLHRSFLPSEN
LVV-CTLNPQSSNNS-IENYLTKMRQELENSITRELRDA-TAE-----LDA---------
---------------------FNVPPRGSA---------NKS------SQDLIAEATQEY
KEILRRR--YMI------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------M-SRSLPGEESG-----------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------G-----LYLVEGKF--
----------------NQIVCLAEGTSA---G------TPDEAAP-------LAER----
---------------TPDTA------------------------E----------SLVEK
PPDEA-----------A-PLVEGTSDK---------------IQCLEKATSGKFEQ-SAE
E---TPREITRPA-----------------------------------------------
----KETSEKFTGRPRKIAWDNKETP-----------VKT--------------------
------GCVAR-------------------------------------------------
------------------------VTSNKTK-V---------------------------
--L---EKGRS---------------------------------------KMIACPTKES
-----------------------------------------------STKA-----S---
TNV-DVSSVESIISLFG---KTTI----EISQSTEVEEDFNLAT----------------
-----------KIISKS----------AAQNY---------------MCLPDA-------
--------------------------------AYQKDIKTINHNIEDQRFSS---ESEQE
EDEE-----------NSWDSGSLLGSSAEIQVC---I---PKSIYQ-KVM----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-EINRKVEEPPEKPSA--FKPATEMQ---------KS--VPNKAF-ELKT----------
--EQTL------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------RADQMFPSES-------------------
----------------------KQKDNEENSWDSESLCETVSQKDVCLPKATHQKE----
----------------------IDKISGKLEGL-SWETCG-----RRKVRTEK----GQE
KG-----LWYGLLKYALYIN--CFA--TCG----MKV--SIQNK---ALELK--------
------------------------------------------------------------
---------------DIQTFKADE---MFPSESKQKDDDN---NSWDSESLSET-VS---
-QTDVCLPKATHQKEIDKISGKLEESPGKDGLLKPTCGMKV---SIQNKAL---EL-KDI
Q--TFKAGKFCNFN--FTLERRILKYLKSFELKNEQ--ILRADSTSLSKILDA----VHS
GKRAREL---A--------------------------YSKM--EQMK-------------
--RSVLK----KQLSEAK---EIKSQLENQKVK-WEQEL--CSGRLTLNQEEEKRRNADI
LN-EKIREE----LGRIEEQ------------------HRKELEVKQQLEEALRIQDMEL
KSVRSNSN----------------------------------------------------
----------Q-VSHPHKNEND---LLHE------NSMLKKEIAMLKLEIATLKHQYQEK
ENKYFEDIKILKERNAELQMTLKLKEETLT--------KRASQYSGQLKVL-IA------
ENTMLTSK-----------------------------------LK-EKQDE---------
--EILDTEIESYHPRLASAVQDH--DQIVTSRKSQE----LAFHIAGDA--CLQGRMNVD
VNNTIYNNEVLH--------------------------Q-PLSETQRESKS--LKI-INY
AG-DALRENTLV-SEH--AQRDQ--CETQCQVKK-----AEHMYQN-EQDNV------NK
HTEQQESVEQKLFQLQSKNMWLRQRLVHAHKKA---DKKSKITINIQF----L-------
---ER-KMQHHLLKEKNEEVFNYV-NHLKDRIYQYEKEKAEREV--SIKKYKY-LSNF--
--LKEN------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------MKKLFTLWRRKD------------------------------
--------------------------------------------------------EPHS
-------------------------------------------------------QPGYN
LRDKDLKK-----LHK---------------AASVGDL----------------------
EK---VKEYLQLKK-HD--VN-MRDREHRVIQFILLSYTIPLNFFTGTAL----------
----------HLAC--ANGYSNIVSLLIEKQCKVNV--WDGENRSPLTK-----------
-AVQCDKESCVTILL-EHGADPNLVDLY----GN--TALHYAA-CHQSDSLVAKLLEHKA
NLEAQNKD-G---YTPLL------LAITENNAEMVE-FLLKSGAD--------VNAS---
-DKNQR-------TA-LMIALS--DEPT--SLVSL-------------------------
--LL-QQE-VNL--------SCQD------IMDSQLRNM---LL-SM---VLL---YR--
--YHELIANYEKKNVK--Q-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------TMKLFGFGSRRG------------------------------
--------------------------------------------------------QTAQ
GS----------------------------------------------ID-HVYTGSGYR
IRDSELQK-----IHK---------------AAVKGDA----------------------
AE---VERCLARRS-G---LD-APDKQ------------------HRTAL----------
----------HLAC--ASGHVKVVTLLVNRKCQIAL--CDKENRTPLIQ-----------
-AVHCQEEACAVILL-EHGANPNLKDIY----GN--IALHYAV-YSESTSMAEILLFHDA
NIEALDKD-N---NTPLL------FAIICKKEKMVE-FLLKNKAS--------THAV---
-DRLRW-------YT-LMLAVH--YDSP--GIVNI-------------------------
--LL-KQN-INV--------FIQD-------CG--DAED---YA-IS---RSL---TK--
--IQQQILEHKKKILKNDK-----------------------------------------
------------------------------------------------------------
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---------------------------------------------------------MKT
EHVDISL----------QNKSDCEAEDVIESPPNF-SQVKSYPRSI--HPSPGSFSKPSQ
MTPL--------------------------------------------------------
------------------------------------------------------------
---------------------------------LLGLKQEESSEEEDEV-----------
------------------EQP--------------HISNAVDKSLI-RNGNSEAQNATED
IAV----RKDMMSALGLEDEEDTESPWDSECA-SESPRKLPAN--Q-------------L
I------------S------------------------------------SDRTEIHMQS
VFEEPNEGLS----------------------------------EKKPDSQLKNTQAILE
TNDITSCPAKG---------------------------KEIDKRQ-----KSDLMEELGL
DD---ADDIEDASDWDSTSISLKNVCDTK----------SPKVLTFGNPS-S--LLSTLT
AK----------------N-----------------------------------------
---DA------AAKDSEVIPPRSEEMS---------------EAQTVTAPE-NTHL-HS-
-----LQKQLLPILKSK----GEEQEDANEK-C---KK----------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------Q-------------------------VE
EEKKKQKCGEMLATEKK------------EDT-----------YK---------------
------------------------------------------------------------
----------------SNMQNLAGNGIDQQMKE---------KLTIQ-------------
--ENQYSIGE-----------------SGET---TKKE--N--PI-KNSVSSK------E
RTKLIQ---IPLKGN----SALNV------------------KDVKKNE-----------
-------------------NKKRI------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----S-----K------------------------------------------------
------------------------------------------Q-----------------
------------------------------------------------------------
-------------------------------RTNQQ------------------------
-------------MNST-----------------NGN-----------------------
------------------------------------------------------------
---------------------------------QFQG--VDDST----------------
------------------------------------------------------------
----------------LSETSQDE---GRPRARTVDEKNK---IGKQMDVAD--------
------------------------------------------------------DF-DEL
TQSSDTATEDFELP--SSNYRDAMLLIEQLN---MD--GK--DSITVLKIQNL----LHG
YERLIEH---EKGR-------------------YTQLLGKVKKLENE-------------
--KRELQ----SVLEETR---ELKSMMDHQKME-WESDV--GSLKFTLKQEEEKRMSTEM
LY-EKNREL----LRKKEDK------------------YSKEMEEKQQLELALRSLEMEL
RTLRNHLK-QVEEERNETQRQLSQEQSARALQEGIL-----NSHLWR--QKEIEEET---
-K-RTVAKSSE-VPDNHDREKD---LLHK------NQILQDEIAILRLELDQIRIRHQEE
ETKYLEENEVLKEKNEDLKKELKLNEEALT--------QTVFQYNGQLNVL-KT------
ESAMLTSK-----------------------------------IEHAKENK---------
--DRLETEMESFRSRLNSAVQEL--ECCHKSKNDVE----RMLQRERDEWLRLQDKLNHD
LSNLRDTNNSLS--------------------------Q-QLSKVESKANS--LENELHH
AT-HTLREKTLL-LES--AQRDL--NHAQCQAKE-----HDHARQI-EKDQM------SK
YIVKQESMQERLAQLQSENVLLRQQLEDMQNKG---IIKEKVVSDVQD----KFSDIFSK
LRADT-EKQIHMMEERNKELITKC-NNLREQIFKYETEKVERES--TVRQLQQELADA--
--LKKQ------SMSEASLEVTTRYRNDLEEDKLHLQKEIDKIKTK-LQESEDQYIQSER
HVHDLKNALDGKEREVNASSQKLQDLLIASSGTNNAIKQLEEHIQRLEIENARLEATTKQ
QTSRIEVLQ----KDLQDSASVHNRLEDLITGLQTAKINLEEQLNQQVQKQTMLSMSAKD
THNMWEEELKSRSKLGVRLSQLDREKAEMLEQFESERK-KMKKL---VELKRSVE-VRLD
QEMKRNSELQKECNGMKKL-----LKAAK--------------KKLKE------YENGES
VSQF-SFQGELKNRYSEIDNEVSRLRSKTDELSRKLDIESKKSMQLEST-----------
-NRDL--REQLSSVKILHKNHEKLEKSKWQLEEEVANLKRQ---VGT-NMMDHSQIEQY-
KREIEERARQEI-RQKLEEVNL---FLQTQAA-SQETLEQ-IRTT-NNASLRNQLEHRIR
DLESEL-ARIKSTQEDGVFQKQSTQAELERYK----ELYLEELKIRKSLA-SKLDRANER
IAEANAKLLHERHR---SKSLIANSIVNGSLSASPVLDPTQLGNLGNNLTLNRSLGLGGS
FIN-TTGNALSSKNR-VEAYLAKMQQELEKSITKELDQA-TVE-----LET-----G---
--------------------SVRVSPVGST---------DGSSKNLNVDQDPVSRATQQY
LDVLKKN--YMI------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

--------------MSFSMKKIFG----AK------------------------------
---------------------------------------------------------EKT
PLGF--------------CDAPQMTVSEFFF--------------GD-----NPNYPKYH
TTYRPLGH-----IHR---------------VAAEGDA----------------------
AQ---MEILITLG-QCS--VS-DRDRK------------------DRTAL----------
----------HFAC--VYGRLPVVTVLVNNNCEIDA--FDKNHITPLIK-----------
-SVQCWKQKCATLLL-EHGADPNVIDSS----GN--SALHYAV-YNGHEEMVALLLQYKA
NIEQ--------------------------------------------------------
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---------------------------------------------------------MTL
---------S----------T--------------T---------CV--NQSYQ------
----MTKGSKK-ISHWHKKEKD---LLHE------NCVLQEEIARLRLEIDTKENRNQQK
ENKYLEDIEIVKAKNDFLQNALTLKEETLT--------TTIYQYSVQLEVS-TA------
ENKTLSSK-----------------------------------LEHKNQNQ---------
--ERLETEIESYRYRPAAAIQDY--DQHQASKRDAE----LGFKRARQEWFHLKEKMNFD
MSNLNDKNKMFS--------------------------E-KLSNAENKIRS--LKMKHHR
IK-DALREKTLV-LEG--IQ-------------------------N-KEGKV------NK
HIQKQDSLEERLSQIQNENLLLRQQLDEARKKA---DNQEKTIINIQE----QFNAIVKN
-QAES-KKQSLLLEQKKKKLVNKC-NYLKERLYKCEKEKAERNV--SIVK----------
------------------------------------------------------------
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-----------------------------

MVA-----EVCSMPTASTVKKPFDLRSKMGKWC---------------------------
----------HHRFPCCRGSGKSNMGTSGDHDDSFMKMLRSKMGKCCRHCFPCCRGSGTS
NVGTSGDHENSFMKMLRSKMGKW-CCHCFPCCRGSGKSNVGAWGDYDH---SAFMEPRYH
IRREDLDK-----LHR---------------AAWWGKV----------------------
PR---KDLIVMLRD-TD--MN-KRDKEK------------------RTAL----------
----------HLAS--ANGNSEVVQLLLDRRCQLNV--LDNKKRTALIK-----------
-AIQCQEDECVLMLL-EHGADRNIPDEY----GN--TALHYAI-YNEDKLMAKALLLYGA
DIESKNKC-G---LTPLL------LGVHEQKQQVVK-FLIKKKAN--------LNVL---
-DRYGR-------TA-LILAVC--CGS-A-SIVNL-------------------------
--LL-EQN-VDV--------SSQD------LSG-QTARE---YA-VS---SHH---HV--
--ICELLSDYKEKQMLKISSEN--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------SNPEQ-----------
---------DLKLTSEE------------------ESQ------------RLK-------
--------------------------------VSENS-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------QPE--------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------KMSQEPEINK-----------
---DCDREVE--------------------------------------------------
---------EEIKKHG--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----SNP------------------------------VGLP------------------
------------------------------------------------------------
-----------------------------------------E-------NL---------
--------------------------------------------------TNG-------
------------------------------------ASA---------------------
---G---------NG---------------------------------------------
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----------------------------------------------D-------------
--DGLIP----QRRSRKP---ENQ-----QFPD-TENEE--Y-HS---------------
------------------------------------------------------------
------------DEQNDTRKQLSEEQNTGISQDEIL-----TN---K--QKQIEVAE---
-QKMNSELSLS-----HKKEED---LLRE------NSVLQEEIAMLRLELDETKHQNQLR
ENKILEEIESVKEKTDKLLRAMQLNEEALT--------KTNI------------------
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-----------------------------

------------------MKRIF---SKKG------------------------------
--------------------------------------------------------ESPL
GSFA----------------RRRRSNSGGGG----------------EPGDGAYLQPRYY
VRDRDLGK-----IHK---------------AASAGNV----------------------
AK---VQQILLLRK-NG--LN-DRDKM------------------NRTAL----------
----------HLAC--ASGHPEVVTLLVDRKCQLNV--CDNENRTALMK-----------
-AVQCQEEECATILL-EHGADPNLADVH----GN--TALHYAV-YNDDMSVATKLLLHDA
NIEARNKD-D---VTPLL------LAVSGKKQQMVE-FLIKKKAN--------ANGV---
-DKLES-------SH-HLISEC--KEER--IPKNSSQNSDSADESSED------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------SLSRLSG--KPGI--------------D----D--SWPTSDD---------
--------EDVNFDTKN-------------------VPKPSLAKLMTASQQSKK---NLE
ATYSIVRT------------------GNRTSFEDRDSDSQ--------------------
---------------------D-------------------EVVI---------------
------------------------------------------------------------
-----------------------------ESLPT--------------------------
----------------------------------TSIKVQGFSHPT--YPSPDPLL-KPS
HKS---------------------------------------------------------
----------------------------------------LANA----------------
-----------------------------------GLTKEGATKLATGKKE---------
---NGIDIIE----SPPLE--------------QTDNDN-------------LTYVDEVP
KNN----RSDMMSALGLGQEEDIESPWDSESI-SENFPQKYVD---------------PL
AGAADQKEKNTGNE---Q------AEG----------------------------MFYIP
SCMSGSRNFKMAKLEDTRNV--------------GMPVAHMESPERYHHLKPT----IEM
-KDSVPNK-----------------------------AGGMK------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------NV------------------
---------------------------------------------QTSI-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------AA
EHDLEVTSEEEQEK-KG-------------SENNQSQVE--------EERRKHR------
---------------------------NNEMEVS---ANIYDSATDDEYD----------
ED-VDDDDGLIR---------E-RSGKTD----RQQFPRKENKEY---------------
---------VSSGPALQTKE-VKRTEK--GKPTSEESVNLLVFEKASLL-----------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------TGGLLQVDDDSSLSE-
-------------------IDEDEG---RPTKKTSNEKNK---VKNQIQSMD--------
------------------------------------------------------DV-DDL
TQSSETVSEDCELP--HSNYKNFMLLIEQLG---ME--CKD--SITLLKIQDA----ALA
CERLLEL---KKNH-------------------CELLTVKIKKMEDK-------------
--VNVLQ----KELSETK---EIKSQLEHQKVE-WEREL--CSLRFNLNQEEEKRRNADM
LY-EKIREQ----LRGKEEQ------------------YRKEVEVKQQLELTLQTLEMEL
RTVKSNLN-QVVQERNDTQRQLSREQNARVLQDGIL-----TNHLSK--QKEIEMTQ---
-KKMNSENSH-----SHEEEKD-----HK------NSVLQKEIAMLRLEIDTIKNQNQEK
EKKCFEDIEIAKEKNEDLQKTIKQNEETLT--------QTISQYNGRLNVL-T------A
ENAMLNSK-----------------------------------LENEKQNK---------
--DRLETEVESYRARLAAAIHDR--DQSETSKRDLE----LAFQRARDEWSRLQDRMNFD
VSNLKDSNEILS--------------------------Q-QLSKTESKLNS--LEIELHH
AR-NALREKTLG-LER--VQTDL--NQTQCQMKE-----MEQKYQN-EQVKV------NK
YIGKQESVEERLSQLQSENMLLRQQLDDAHNKA---DNKEKTVINIQE----QFCAIVQK
LQAES-EKQSLLLEERNKELISEC-NHLKERQYQYENEKAER EV--VVRQLQQELADT--
--LKKQ------SMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQ-LQEAQDQHTEAVR
C-----------------------------------VEKMQDHKQKLEKDNAKLKVTIKK
QMDKIEELQ----KNLLNA-----------------------------------------
------------------------------NLSEDEKE-QLKKL---MELKQSLECN-LD
QEMKKNVELEREITRFKNL-----LKMTR--------------KKLNE------YENG--
--EF-SFHGDLKTSPFEMDIQINKLKHKIDDLTAELETAGSKCLHLDTK-----------
-NQVL--QQELLSMKTIQKKCEKLQKNKVKLEQEVVNLRSH---IER-NMVECGQIKQY-
KQEIEERARQEI-VEKLKEVNL---FLQAQAT-SQENLEQ-LREN-NFASM KSQMELRIK
DLESEL-SKMKTSQE------DFNKTELEKYK----QLYLEELKVRKSLS-NKLNKTNER
LAEVNTKLLVEKQQ---TRSLFT------TLTTRPVLESPCVGNLNNSLDLNRKLIPREN
LVI-STSNPRTSNNS-MEKYLTKMQQELEKNITRELEEA-AAE-----LES-----G---
--------------------S-VASPLGST---------DES----NLNQDLVWKASREY
VQVLKKN--YMI------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------M----------
----------HFAC--FYGHLELVIYLWRRGCEINV--CDNHNITPLMK-----------
-AVQSWEDKIVCFLL-EHHANLHIKDSM----GN--TALHYAV-YSGNSATAARLLQYGA
DIEERTKD-N---LTPLL------LALRENRLKMAQ-FLVRMEAS--------VHAV---
-DSQRR-------NS-LMYAVR--CDSP--VMVNL-------------------------
--IL-QQG-VDT--------NLKD------LFG-WTALR---YA-IE---GDR---D---
--VRTILLELRKRNRAFQS-----------------------------SEN-SSIRLIN-
KADAEVTSPTANETLGIKRRPMDQ------TQIVMLDSSI-L---INKIRNE--KGDIT-
---------TDPEE------------------------IQNT---ITSFYKSLY------
------SIKLEN-----------------------------LDEMDKFLDRY--------
--------QNPGQRSA--KTDA-----------ATE--------NRSP------------
------------------------------------------------------------
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-----------------------------

MVA-----EVDSMPAASSVKKPFGLRSKMGKWC---------------------------
----------CHCFPCCRGSGKSNVGTSGDHNDSAMKTLRSKMGKWCRHCFPSCRGSGKS
NVGTSGDHNDSSVKTLGSKMCKW-CRHCFPCCRRSGKSKVGAWGDYDD---SAFMDPRYH
VHGEDLDK-----LHR---------------AAWWGKV----------------------
PR---KDLIVMLRD-TD--VN-KRDKQK------------------RTAL----------
----------HLAS--ANGNSEVVKLLLDRRCQLNV--LDNKKRTALIK-----------
-AVQCQEDECALMLL-ERGTDPNIPDEY----GN--TTLHYAI-YNEDKLMAKALLLYGA
DIESKNKH-G---LTPLL------LGVHEQKQQVVK-FLIKKKAN--------LNAL---
-DRYGR-------TA-LILAVC--CGS-A-SIVSP-------------------------
--LL-EQN-VDV--------SSQD------LSG-QMARE---YA-VS---SHH---HV--
--ICQLLSDYKEKQMLKISSEN--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------SNPEQ-----------
---------DFKLTSEE------------------ESQ------------RLK-------
--------------------------------GSENS-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------QPE--------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------KMSQEPEINK-----------
---DGDREK---------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------KYG--STHVG------------
-------------F-------------------PENLTNGATAGNGD-------------
--DGLIP----PRKSRTP---ESQ-----QFPD-TENEE--Y-HS---------------
------------------------------------------------------------
------------DEQNDTQKQLSEEQNTGILQDEIL-----IH---E--EKQIEVAE---
-K-KMNSEVFSLVIFKCFYMCV---YF---------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-----------------------------

------------------MKKIFGFGSKKG------------------------------
--------------------------------------------------------ESPL
GSSI----------------SPGRDG-----------------------GHRINLQPGYR
IRDKDLGK-----IHK---------------AAIVGNV----------------------
AK---VQQILLLGK-NG--LN-DRDKM------------------NRTAL----------
----------HLAC--ANGHSAVVTLLLERKCLLNL--CDNENRTALMK-----------
-AVECQEEECATLLL-EHGADPNVMDVS----GN--TALHYAV-FCQNISLAAKLLSYDA
NIEARNKD-D---LTPLS------LAVSERKQQMVE-FLAKKEAN--------IHAV---
-DKMQS-------IR-QLISEY--KEER--PKTPPE--NSNPEDESSEE-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------DSLSRFSN--KPGV--------------D-------SWPTSDD---------
--------EDLDLETKN-------------------VLKPSLTKLMNASQQSRRN---IE
AKCGIVRP------------------ESTTFSEDNNSDSE--------------------
---------------------I-------------------EDVV---------------
------------------------------------------------------------
-----------------------------ETIPE--------------------------
----------------------------------PSPGVQGFSHPA--FPSAEPLPQPLK
SLA---------------------------------------------------------
------------------------------------------GL----------------
-----------------------------------GLTKARATKPEIVDKE---------
---SDTDIIE----RAPQE--------------QINHDH-------------LSSVDATH
KNN----RSDMMSALGLGEEEDIESPWDSESI-SESLPQKYV-D--------------LL
SGAAGQRGKNTLNG---Q------VED----------------------------VSYIP
SCMIGSRNFKMAKLEEPRHV--------------GIPVAHMDSPEKYPNVKPA----VLV
-KDS--VP-----------------------------SKTV-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------GMKD----------------
--------------------------------------------LQTSS-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------SA
ELDLEMTSEEEEEKPVG-------------DKNNHSQVE--------EEKKKHK------
---------------------------SSEVEIS---DNV--CDTA--------------
-----DESGLIQ---------QRKSGGNS----SQEFAAMENEG----------------
---------SDSDPDVHRKE-VKKKDN--SKWTPEGCVTAPIFEKTDSL-----------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------TGGLLHVNDDSILSE-
-------------------VDQDDD---RPAKKTSNENNK---VKEQINSVD--------
------------------------------------------------------DL-DDL
TQSSETASEDGELL--Y--YKNSMLLIEQLD---TG--CKD--SVSLLKIRDT----ILS
YERLVEL---KKSH-------------------CELLKGKIKKMESK-------------
--VRGLQ----KELSETK---EVKSQLEHQKVE-WEREL--GSLRFTLKQEEEQRRNADM
LY-EKIREQ----LRRKEDQ------------------YSKEVEMKQQLELTLRALEMEL
KTVRNDLN-QVIEERNDTQKQLSRERNARILQDEIL-----ANHLAK--QKEIEMAN---
-KEMNSEVSD-----SCEEAKD---LLHK------NHMLQEEIAMLRLEMDAVKIQNQEK
EKKYFEDIEIVKGKNDDLQKAIKVNEETLT--------KTVSHYTGQLNAL-T------A
ENTMLNSK-----------------------------------LENEKESK---------
--QRLETEVESYRSRLAAASHDH--DQCQTSKRDLE----LAFQRARDEWLHLQDKMKSD
AANLKDNNEMLS--------------------------Q-QLSRAESKFNN--LEIKLHH
TR-DSLREKILM-LER--VQRDL--SQTECQKQE-----IEHMYQN-EQGKV------NK
YIGKQESLEERLSQLQSENMLLRQQLDDAQNKA---DSKEKTVISIQD----QFQQIVRK
LHAES-EKQGLMLEERNKELVKEC-DHLKERMYQYENEKAEREV--SVRQLQQELADT--
--LKKQ------SMSEASLEVLSRYRANLEVEAQDLKKKLGQLTSQ-LQEAQDQLTEAVR
C-----------------------------------AEKTQDRVQKLEIENAELQTTVKK
QAGKIEQLQ----KNLLST-----------------------------------------
------------------------------RSSEDEKE-QLKKY---IELKQSLENS-LD
QEKKKNSELEKEITGFKKL-----LKMTR--------------RKLNE------YENG--
--EL-SFHGDLKTSQTEMDIQINKLKHKIEDLTAELEAASSKCLHLDAK-----------
-NQVL--REELLSMKGMQKKCEKLEEKKKKLEQEVVHLRSH---IEM-NMIEHSQVEQY-
KREIEERARQDL-VEKLKEVNL---CLQVQAA-SQENLEQ-LQEK-NNASIRSQMELRIK
DLESEL-SKVKTLQE------DSHKAELEKYK----QLYLVELEVRKSLE-GKLDKTHER
LAVISTKLEVEKEQ---NRSLLS------TLSTRPVLEPPCVGNFNNPVVLNGNLTPRAN
VGF-STSIPRPSNNS-METYLTKMRQELDRSITRELREA-AAE-----FE----------
---------S---------ESYGLSPLGAT---------DGS----NLSEDLLLKTSQEY
VQILKKK--YDLKDK---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------------------------------------------------
------------------------------------------------------------
-------------------ME----R---LC-------------------SDGFAFPHYY
IKPYHLKR-----IHR---------------AVLRGNL----------------------
EK---LKY-LLLT-YYD--AN-KRDRK------------------ERTAL----------
----------HLAC--ATGQPEMVHLLVSRRCELNL--CDREDRTPLIK-----------
-AVQLRQEACATLLL-QNGADPNITDVF----GR--TALHYAV-YNEDTSMIEKLLSHGT
NIEECSKN-E---YQPLL------LAVSRRKVKMVE-FLLKKKAN--------VNAI---
-DYLGR-------SA-LILAVT--LGEK--DIVIL-------------------------
--LL-QHN-IDV--------FSRD------VYG-KLAED---YA-SE---AEN---RV--
--IFDLIYEYKRKR-YEDLPINS-----NPVSPQ----------------KQR-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------AEKAT----SDD
-KDSVSNI-----------------------------ATEIKEGPISGTVSSQK------
------QPAEKATSDEKDSVSNIATEI---------------------------------
-----------KEGQQSGTVS--------PQKQSAQKVIFKKKVSLL--NI------ATR
IMGGG---KS--GTVSSQKQPASKTASDKTD----------SALNTATEIKDG-------
------LQCGTVSSQKQQALKAT---TDEEGSVSNIATE-----------------IKDG
EKSGTVSSQKKPA-----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------L-------KATSDEKD-SF-SNI-TREKKDGEIS-----R---TVSSQK
PPALKATS---------------VKEDSVLNIAREKKDGEKSRTVSFEQPPGLKATR---
-----------------DEKDS-LLNIARGKKDGEKTRR---------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------VSSHKQPS-----------LKATSDKEDSVPNMATET-KD------------
EQISGTVSCQKQPALKATSDKKDSVSNIPT-------E--I----------KDGQQSGTV
-----------------------------------SSQKQ--PAWKATSVKKDSVSNIAT
------------------------EIKDGQIRGTVSSQRRPALKTTGDEK----DSVSNI
AREIKDGEKSGTVSPQK---------Q-------SAQKVIFKKKVSLLNIATRITGGGK-
-------------------------------SGTEYPENLRTLKATIEN-----------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------KD-SVL-NTATKMKEVQTSTPA
EQDLEMA------SEGEQKRLEEYEN-NQPQVKNQIH---------SRDD----------
-------------------------------------------------------L-DDI
IQSSQTVSEDGD--SLCCNCKNVILLIDQHE---MK--CKD--CVHLLKIKNT----FCL
WKRLIKL---KDNH-------------------CEQLRVKIRKLKNK-------------
--ASVLQ----KRISEKE---EIKSQLKHEILE-LEKEL--CSLRFAIQQEKKKRRNVEE
LH-QKVREK----LRITEEQ------------------YRIEADVTKPIKPALKSAEVEL
KTGGNNS-----------------------------------------------------
---------NQ-VSETDEK-ED---LLHE------NRLMQDEIARLRLEKDTIKNQNL--
EKKYLKDFEIVKRKHEDLQKALKRNGETLA--------KTIACYSGQLAAL-T------D
ENTTLRSK-----------------------------------LEKQRESR---------
--QRLETEMQSYRCRLNAARCDH--DQSHSSKRDQE----LAFQGTVDKCRHLQENLNSH
-------VLILS--------------------------L-QLSKAESKSRV--LKTELHY
TG-EALKEKALV-FEH--VQSEL--KQKQSQMKD-----IEKMYKS-GYNTM------EK
CIEKQ----ERFCQLKKQNMLLQQQLDDARNKA---DNQEKAILNIQA----RCDARVQN
LQAEC-RKHRLLLEEDNKMLVNEL-NHSKEKECQYEKEKAEREV--AVRQLQQKRDDV--
--LNKG------SATKALLDASSRHCTYLENGMQDSRKKLDQMRSQ-FQEIQDQLTATIR
C-----------------------------------TKEMEGDTQKLEVEHVMMRKIIKK
QDDQIERLE----KILQHS-----------------------------------------
------------------------------SLM-------------------LQVFE-S-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
-----------------------------

------------------ME-------KKS------------------------------
--------------------------------------------------------TAWN
GWGL--------------LPFSFNLRPLRVRSP----------PMTMTVASFHSPGPGYH
IRYQDLRG-----IHR---------------AVIEGDT----------------------
EKMQEIQQLLVFGL-HD--LN-KRDRK------------------NRTAL----------
----------HLAC--AIGSVDMVKILVLSQCQLNL--RDGENRTALVK-----------
-AVQCQEEACVDILL-RKGADVNTKDFK----GN--TALHYAA-YEGNISIACKLLLNKG
DIEAKNKD-G---LTPLL------VAVNEKKEKMVA-FLL-EEAN--------INAV---
-DYTNR------------------------------------------------------
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-----------------------------

------------------MNKLFNFWKRKN------------------------------
--------------------------------------------------------ETH-
-------------------------------------------------------SQGYN
LREKDLKK-----LHR---------------AAAVGDL----------------------
KK---LKEYLQLKK-YD--VN-MQDKK------------------YRTPL----------
----------HLAC--VNGHRDVVLFLIEQQCKINI--RDSENKSPLIK-----------
-AVQCQNEDCATILL-NCGADPNLRDIH----YN--TALHYAV-CGQSVSLVEQLLDYEA
DLEMKNKD-G---YTPLL------AAVVSNNPKMVK-FLLEKGAD--------VNAS---
-DNYQR-------TA-LILAVS--GEPT--RLVNL-------------------------
--LL-QQG---------------------------LRNI---LI-SM---VLL---YI--
--HNSLQVMERRNMLN--RHLIL-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------G--------------
----------TT--CD--------------------------------------------
------------------------------------------------------------
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-----------------------------

MEEEINY-------GAQTMN--I------P------------------------------
---------------------------------------------------------RRR
RWYT--------------RL--WHSCLGLRC--------------MH--PQKKKKYPLYL
IGYDPIGP-----LQR---------------AASVGDL----------------------
DT---TEKLIHSS-QHH--VD-ESDRR------------------KRTSL----------
----------HYAC--AHNHPDVVTLLLENNSSINI--RDDEGCTPLIK-----------
-ATQRDNVDCASVLL-THNADPNLIDFS----GN--TALHHAI-SRGNLRIVKMLLEHNV
DIEAKTEY-G---LTPLQ------LATFEQKPEMVE-FLAAKCAK--------SSVT---
-PSWSP-------SP-TVSPCP--SSTS--PLSSL-------------------------
--GL-HVC-PNP--------GTSS------LSE-DRKSS---SA------RRI-------
-KL---------------------------------------------------------
STGSSAQRTEVKHVRFN-EEVLYF------KEERPLSCEARPPGQLKSILKNT------V
--------------------------------------QYNTVNEKITRRTSLW------
------CSKGEDVR------------------YTSCIKVKCFSVKSSFL-----------
------------------------------------------------------------
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-----------------------------

------------------MKKIFGFGSRKG------------------------------
--------------------------------------------------------VSPL
AAST----------------SPGRSL-GERP----------------PGGGRGASQRGYH
VRDRDLGK-----IHR---------------AASVGSV----------------------
AK---VKQILLLRI-NG--LN-DRDKM------------------NRTAL----------
----------HLAC--ANGHPGVVTLLADRKCLLNL--CDNENRTALIK-----------
-AVQSQEEECVTILL-DHGADPNIMDID----GN--TALHYAV-LGQNIVIVEKLLSFKA
NIEARNKE-D---LTPLS------LAQSENKEQMVE-FLVNRGAR--------IRTV---
-DQMES-------NQ-QVTSEY--KEER--RTKKSSESSKSFGKTSN------SDLLFIF
YSIV-FRC-DSN--------KVSQ------ESV-WQNQK---WG-L--------------
---GPLES----WE----------------------------------------------
------------------------------------------------------------
----------------------------------------------------T-------
-------G----------------------------------------------------
DAELHRPMSQGRLFSS--KPGI--------------D----D--SWPTSED---------
--------EDFDFDTKN-------------------FMKPSLAKLKTAIQQSQK---NIE
AKYAIVRS------------------ENRTLYEDNNFHSE--------------------
---------------------N-------------------EDVV---------------
------------------------------------------------------------
-----------------------------ETFPN--------------------------
----------------------------------TSEQIQGFSQPA--FSSLEPVLKASP
M-----------------------------------------------------------
---------------------------------------SSAVI----------------
-----------------------------------GLTKEDAIKPTIKKKE---------
---NGIDIIE----SAPKS--------------QINNDN-------------LTYVDGDH
KNS----SSDKMSALGLGEDEDTESPWDSESF-STSLPQKFVD---------------HL
PEAADQRGKYILNE---Q------VE----------------------------------
-----------------------------------------DSPGKYSHLKPT----LVV
-TDPVPNK-----------------------------AEGMK------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------GV------------------
---------------------------------------------QASK-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------SA
ELDLEMTSQEEQERLNG-------------RENNHPQVE--------EEKKMHR------
---------------------------GCEMEVT---ENFHNADAD--------------
-----DSDELIQ---------QRKSGQTN----NQQFPTMENEDV---------------
---------VV--NGLQMKE-VKK--N--EKWTSEEPVITPTFEKADSL-----------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------SGSLPQVNDNRCLNE-
-------------------IESAKQ--TSSEEKTSSEENK---VKEKIGSVD--------
------------------------------------------------------DL-DDL
TQSSEIISEHCEVP--YSSYKNSMLLIEQLG---MN--CKD--SISLLKIQDT----VLS
YERLIEL---RKNH-------------------CEMLTGKIKKMEKR-------------
--ISGLQ----KELSETK---EMKSQLEHQKVE-WEQEL--CNLRFTLKEEKEKRRNTDL
LY-DKIREQ----LRNKEEQ------------------YIKEVEVNQQLETTLRTLEMEL
KIIRKNLN-QVVEERNDIQRQLSREQNARILQDGIL-----ANHLCK--EKEIEIAH---
-KKMNSEVSD-----NYEKEKT---LLHE------NHMLQDEITKLRLEIDTVKNQNQEM
EKKYVEDIAILKEKNDHLQKTIKLNEETLT--------RTTFQHNGQLDVL-T------A
ENTMLNSK-----------------------------------LENEKQNR---------
--ERLEAEVESYRSRLATAIQDH--EHCQTSKRDLQ----FAFQRERDEWFCLQDKMKFD
MSNLKDSNEVLS--------------------------Q-QLSKAESKFNN--LEIELHH
TR-DALRERTLV-LEG--VQRDL--SQTQCQKKE-----IEHMYQK-EQGKV------NK
YVGKQGSLEERLSHLQSENMLLRQQLDDAHNKA---DSKEKTVINIQD----QFQDIIKI
FQAES-EKQGLMLNERNKELINEC-NNLKERMYQYENDKAERDA--VVRQLQQELADT--
--LKKQ------SMSEASLEVTSRYRMNLEDEKQELKKELDQSRSQ-LQEAQDRCTAAVK
C-----------------------------------AEETQEHMQKLEIENDKLKVTIKK
QAHKIEQLQ----TNLLGK-----------------------------------------
------------------------------NSSQDEKE-QLKKY---IELKQSLEYS-LD
QEMKKNDQLEKEITRFKKL-----LKITK--------------RKLNE------YENE--
--EL-SFPGDLKPNQVEMDIQINILKHKNDDLTAKLESASSKCIHLDEK-----------
-NKFL--QQELLSMKAIQKKCEKLENEKKKWKQEVVNLKRL---LEM-NVVEFGEVEQY-
KRKIEERARQDV-VEKLKEVNL---FLQTQAA-SQENLEQ-LREN-HNTSIRSQLELRIK
DLEYEL-FKMKTSQN-------SKEIDLEKYK----QLYLEELEGRKSLA-NTLNKTNER
LAEVSTELLLQKQQ---NRSLLS------VPNTRPVLETPGVGNFNNSFVLYGHSLPREN
MVN-PTSRPRLSNNS-IETYLIKMQQDFEKTLTRELKED-AAE-----FES-----E---
--------------------SYRAYPVGLV---------DQS----NSYEDLLLKTSREY
VQILKKN--YMI------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------MW--KP-CLSSQ------------------EKTAL----------
----------HLAC--AHGHPGVVADLVARKCQLNL--TDSENRTALIK-----------
-AVQCQEEVCASILL-EHGANPNVRDMY----GN--TALHYAI-DNENISMARKLLAYGA
DIEARSQD-G---HTSLL------LAVNRKKEQMVA-FLLKKKPD--------LTAI---
-DDFGR-------TAL-ILAAR--NGS-------------------TS----------VV
YQLL-QHN-IDV--------FCQD------ISG-WTAED---YA-VA---SKF---Q---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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----------------------------------------AIRG--------------II
SEYK--------------------------------------------------------
------------------------------------------------------------
-----ANK-------------------------------RR-------------------
------------------------------------------------------------
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---------------------------------------------K---S----LQNSDP
EQDLETTSEGEQERLEG-------------CESSQPQVE--------EKMKKCR------
---------------------------NKKMEVS---RNVHADDSDNY------------
---NDDVDELIH---------KIKNRKPD----NHQSPGKENGEF---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------DRLARKTSNEKSK---VKSQIYFRD--------
------------------------------------------------------DL-NDI
TGSSEKTSEDDELP--YSDDKNFMLLIEQSG---ME--CKD--FVSLLKSKNA----TAA
CGRSIED---QKCY-------------------CEQLKVKFQKMKNN-------------
--ISVLQ----KVLSETD---KTKSQSEHQNLQ-GKKKL--CNLRFILQQQEEERIKAEE
LY-EKDTEE----LKIMEEQ------------------YRTQTEVKKQSKLTLKSLEVEL
KTVRSNLN-QNS------------------------------------------------
--------------HTHEKERD---LWQE------NHLMRDEIARLRLEIDTIKHQNQET
ENKYFKDIEIIKENNEDLEKTLKLNEETLT--------KTITRYSKELNVL-M------D
ENTMLNFE-----------------------------------LQKEKQST---------
--SRLETEMESCHCRLAAALCDH--DQRQSSKGDLQ----LAFQNTVNEWCHLQEDTNSH
I-------QILS--------------------------Q-QLSKAESTSSG--LETELHY
ER-EALKEKTLH-IEH--MQGVL--SRTQRRLED-----IEHMYQN-DQPIL------EK
YVRKQQSVEDGLFHLQSQNLLYQQQCNDARKKA---DNQEKTIINIQV----KCEDTVEK
LQAEC-RK----LEENNKGLMKEC-TLLKERQCQYEKEKEEREV--VRRQLQREVDDA--
--LNKQ------LLLEAMLEISSERRINLEDEARSLKKKLGQMRSQ-VCMKLSMSTATL-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

MVA-----EVCSMPAASAVKKPFDLRSKMGKWC---------------------------
----------HHRFPCCRGSGKSNMGTSGDHDDSFMKTLRSKMGKCCHHCFPCCRGSGTS
NVGTSGDHDNSFMKTLRSKMGKW-CCHCFPCCRGSGKSNVGTWGDYDD---SAFMEPRYH
VRREDLDK-----LHR---------------AAWWGKV----------------------
PR---KDLIVMLRD-TD--MN-KRDKQK------------------RTAL----------
----------HLAS--ANGNSEVVQLLLDRRCQLNV--LDNKKRTALIK-----------
-AVQCQEDECVLMLL-EHGADGNIQDEY----GN--TALHYAI-YNEDKLMAKALLLYGA
DIESKNKC-G---LTPLL------LGVHEQKQEVVK-FLIKKKAN--------LNAL---
-DRYGR-------TA-LILAVC--CGS-A-SIVNL-------------------------
--LL-EQN-VDV--------SSQD------LSG-QTARE---YA-VS---SHH---HV--
--ICELLSDYKEKQMLKISSEN--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------SNPEQ-----------
---------DLKLTSEE------------------ESQ------------RLK-------
--------------------------------VSENS-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------QPE--------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------KMSQEPEINK-----------
---DCDREVE--------------------------------------------------
---------EEIKKHG--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----SNP------------------------------VGLP------------------
------------------------------------------------------------
-----------------------------------------E-------NL---------
--------------------------------------------------TNG-------
------------------------------------ASA---------------------
---G---------NG---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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----------------------------------------------D-------------
--DGLIP----QRKSRKP---ENQ-----QFPD-TENEE--Y-HS---------------
------------------------------------------------------------
------------DEQNDTQKQLSEEQNTGISQDEIL-----TN---K--QKQIEVAE---
-KEMNSELSLS-----HKKEED---LLRE------NSMLREEIAMLRLELDETKHQNQLR
ENKILEEIESVKE---KLLKAIQLNEEALT--------KTSI------------------
------------------------------------------------------------
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-----------------------------

------------------------------------------------------------
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--------------------------------MFFSV--SQDDL---TPLLLGISERKQQ
IVEFLVRKGA----NIHAVDKMKRTALILAVNYESLNVVSLLLQRGADVFSQDVFGRTAE
EYAVISGFKIVC--ELISEYKEKRPK-TPPEKSNSVDKS----SEE--DSLS----------------------YNS-FIQ-----------------------------------------------------------------VDTCCSSSSD--F-----LLQPA---------------------P---------KLNLQKLMK----AFQ------------------QSKRK-EAECGIVRQESTTFSE-----NNNSDSEIEDVV-ETLPKPSPGV-------------------------------------QGFSHP--------A---FPRP----------DPL--------LKPLKTLAGLGLAKV----------------------EGEKKH--RSS------------ESRLIQQ-RKSGG---------NNK------QAF-------SAMETKGSDR---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QIVEFLVRKGA----NIHAVDKMKRTALILAVNYESLNVVSLLLQRGADVFSQDVFGRTAEEYAVISGFKIVC--ELISEYKEKRPK-TPPEKSNSVDKS----SEE--DSLS--------
--------------YNS-FIQ---------------------------------------
--------------------------VDTCCSSSSD--F-----LLQPA-----------
----------P---------KLNLQKLMK----AFQ------------------QSKRK-
EAECGIVRQESTTFSE-----NNNSDSEIEDVV-ETLPKPSPGV----------------
---------------------QGFSHP--------A---FPRP----------DPL----
----LKPLKTLAGLGLAKV----------------------EGEKKH--RSS--------
----ESRLIQQ-RKSGG---------NNK------QAF-------SAMETKGSDR-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------MKRLCAACVKRE------------------------------
--------------------------------------------------------TGPE
RPSP-------------------------------------------FSQLVYTDNNSYV
IHHGDLRK-----IHK---------------AASQGQA----------------------
WK---LEKM-IKKTTMDLN---IKDAK------------------KRTAL----------
----------HSAC--FSGHEEVVTLLVDRKCQLDV--LDGENRTPLMK-----------
-ALQCQRDACANILI-DSGADPNIVDVY----GN--TAVHYAV-YSENLSVVVKLLSCGA
DIEVKNKA-G---HTPLL------LAIRKRSEQIVE-FLLTKNAN--------ANAV---
-DKFKC------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------I--H-------------------------QQLLEYKQ--------
-----------K------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--ISKNSQ-------------------------------------------NS-------
------------------------------------------------------------
-------------------------------------------------NP---EGTSAG
TTEEA-------------------------------------------------------
-------------APLAER-------------------------------------T-PD
KAE---------------------------------------------------------
------------------------------------------------------------
-------------------GSV--EGTPDE------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-----------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--MAS---------------RGGEKRGGSEGSPKPTVSAMRKTPSV--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------GS---QEDQL-
----------SLSYLGDQWSSDSLRW-LSDSAGSDSE--------H-------------V
EGAL--------------------------------------------------DQP---
-----QHDVRLEDLCERHRA--------------ARSGD-------VP-----GVERVLA
PGD-----------------------------------PGVNKRD-RKESLRHLIPECKM
EQSPESLPQNNNPDWHPTNLTISDKTCQKSKILNVDDQCPSVSPSMPENQSATKELGQMN
LTEQEKM----------N---------------------VSGNDSLH--DLC-QSQLPE-
----------------------NKESK---------------E------AEQELELTSEE
E---QERLKGHENKQPE----KMSQEPEMAKDCDRED------------------IPVYS
ILPHVQKSEEMWIEQGKLEWKNKLKL-----------VTNELKQRFGE------------
------ICETYKIP----------------------------------------------
----VCPEEEPLLDNSMRKTNVKDIPFNLTN-N-------------------------IP
GCEEEDASEVSVSVVFETFPEQNEPSLKSIIH---------PYCHPYSGSLEHACQSSSK
LHLHENKLDYDSDNKPGIEHIFSMDEN-FSNDAGIKKAR-NPEEVTVEMKE-----G---
QEF-DLQMTKNMNQNSDSC-----------------------------------------
---------------------------TTNNYKSLKPKL-E--NL-SSLPPDSDRTSEVY
LHEELQ---QDMQKPKTEVDRVEEMF-----LALKKENVQLQKEVEEEVEKH---RSNST
ELSG-----------NPAHGAAAG------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------NNDDGL-NQQ-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------FPRKK-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------KKGH-DRPVDKTSNEKNK---VKNQVH-----------
---------------------------------------------------HEADF-ADS
VGPSETASEDCELS--HFTYENFLLLIEQLG---ME--RKDTDSISLSRSQDT----FCL
YEHLLKL---KNND-------------------YEQLTVKIKQTENM-------------
--ASVLQ----KELSETK---KTKLQLELQKIE-LEKQL--YSLRLALKQEKEEKGNAVM
LY-NKYSER----LRLKEEE------------------CGKEVETKQLLKWTLRRLVKEL
KTVRKNLD-LVVQERNDVQKQLSEEQNARILQDQIL-----TS---K--QKELE------
--IAQKKINSE-ISHRHKKEKD---LLHE------NCMLREEIALLRLEIDTVNNQNQQK
EKKYFEDIEVVKEKNDNPQKIIKLNEEKLT--------KTILQYSGQLNDL-TA------
ENKILNSE-----------------------------------LENEKQNQ---------
--ERLEIEMESYHCSLAAALHDC--DQSQT-SRDPK----LDFQRTRQEWVHLQDKKKVD
MSDLQAKTEILS--------------------------E-KLSNAESKISS--LQIQLHN
TR-DAVKRKSLI-LER--LQRDL--SQTHCEKKE-----TEQMYKN-EQHKL------KK
YIAKQESVEERLSQLQSENTLLRQQLDDAHKKA---NSQEKTISTIQD----QFHAFAKN
LQAES-EKKILSLQEKNKELMDEY-NHLQERMHQCEKEKAGRKV----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------DLIEAQETVPSQCLHLDAE-----------
-NEVLQLQQTLFSMKAIQMQCETLQKNKQQLEREVVNLKSY---MER-SMLECVEAEQH-
KLLIEEKARKEI-AEKLNEAIP---TLQKQAAVSQEQLAQ-LRED-NTTSVKTQMELTIK
NLESEI-SRINTSSANF------NKTELERYK----ELYLEEVKVRESLS-NELNRTNEK
IAEVSAQLTVEKELTR---SPFA------ACSTRPILEPPCAGNLNDSEDLNRKHIPRKK
KSA---------PES-MGSYLLKMQQKLQNDITTEVTAS-SQTGLHRTPQW-----G---
--------------------DRSSKS-----------------FSIQ------------I
CSIAVPE--FLSLYIVIDLSLDRH------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

MVA-----EVCSMPAASAVKKPFDLRSKMGKWC---------------------------
----------HHRFPCCRGSGKSNMGTSGDHDDSFMKTLRSKMGKCCHHCFPCCRGSGTS
NVGTSGDHDNSFMKTLRSKMGKW-CCHCFPCCRGSGKSNVGTWGDYDD---SAFMEPRYH
VRREDLDK-----LHR---------------AAWWGKV----------------------
PR---KDLIVMLRD-TD--MN-KRDKQK------------------RTAL----------
----------HLAS--ANGNSEVVQLLLDRRCQLNV--LDNKKRTALIK-----------
-AVQCQEDECVLMLL-EHGADGNIQDEY----GN--TALHYAI-YNEDKLMAKALLLYGA
DIESKNKC-G---LTPLL------LGVHEQKQQVVK-FLIKKKAN--------LNAL---
-DRYGR-------TA-LILAVC--CGS-A-SIVNL-------------------------
--LL-EQN-VDV--------SSQD------LSG-QTARE---YA-VS---SHH---HV--
--ICELLSDYKEKQMLKISSEN--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------SNPEQ-----------
---------DLKLTSEE------------------ESQ------------RLK-------
--------------------------------VSENS-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------QPE--------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------KMSQEPEINK-----------
---DCDREVE--------------------------------------------------
---------EEIKKHG--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----SNP------------------------------VGLP------------------
------------------------------------------------------------
-----------------------------------------E-------NL---------
--------------------------------------------------TNG-------
------------------------------------ASA---------------------
---G---------NG---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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----------------------------------------------D-------------
--DGLIP----QRKSRKP---ENQ-----QFPD-TENEE--Y-HS---------------
------------------------------------------------------------
------------DEQNDTQKQLSEEQNTGISQDEIL-----TN---K--QKQIEVAE---
-KEMNSKLSLS-----HKKEED---LLRE------NSMLREEIAMLRLELDETKHQNQLR
ENKILEEIESVKE---KLLKAIQLNEEALT--------KTSI------------------
------------------------------------------------------------
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-----------------------------

MVA-----EVSPKLAASPMKKPFGFRGK--------------------------------
------------------------------------------------------------
-------------------MGKW-CCCCFPCCGRSGKNNMGAWRDHDD---SAFTEPRYH
VRREDLGK-----VHR---------------AAWWGEV----------------------
PR---ADLIVMLRG-PG--IN-KRDKKK------------------RTAL----------
----------HLAC--ANGNSEVVRLLLDRQCQLHV--FDSKKRTALIK-----------
-AVQCQEDECALMLL-QHGTDPNLPDVY----GN--TALHYAV-YNEDKLMAKTLLLYGA
DIESKNKG-G---LTPLL------LAVHGQKQRMVK-FLIKKKAN--------LNAL---
-DRFGR-------TA-LILAVH--CGS-A-SIVSL-------------------------
--LL-QQN-IDV--------FSQD------VFG-QTAED---YA-VS---SHH---NI--
--ICQLLSDYKGNQMPKNSSGN--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------KQ-----------
---------DLKLTSEE------------------EPQ------------RLK-------
--------------------------------GNENS-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------QHE--------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------EVTPEPDINK-----------
---DCDREVE--------------------------------------------------
---------EEMQKHG--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----SNN------------------------------VGLS------------------
------------------------------------------------------------
-----------------------------------------E-------NL---------
--------------------------------------------------TDG-------
------------------------------------AAA---------------------
---G---------NG---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------D-GGLV---------------------------P----
----Q-------------------------------------------------RKSRKH
----------------------------------------ENQ-----------------
--QFPNTE------------------------------------------------IE--
------------------E-----------------------------------------
----------------------------------------------------YH------
-SKSCQ------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------VYWKNTSRSQSY------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------LV--YLN--SASLSKIQDA----VIS
DEHLLEL---KNSH-------------------YEQLTVEIEQVENM-------------
--VHVLQ----KELSEAK---ETQLQLAHQKGE-CEQER--CSLR---------------
------------------------------------------------------------
------------YDILVLEKYFNSLF----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-----------------------------

------------------MKKIFGYRSEKG------------------------------
--------------------------------------------------------ESPL
DSS-------------------I--------SL----------GRDR-GHRRTSFQPGYH
IRDRDLTK-----IHK---------------AASVGNV----------------------
AE---VQQVLLLRK-NG--LN-DRDKK------------------NRTAL----------
----------HLAC--ANGHSAVVTLLLERKCLLNL--CDNEKRTALMK-----------
-AVECQEEECATLLL-EHGADPNVMDVC----GN--TAVHYAV-FCQNLSLAAKLLSYDA
DIEARNKD-D---LTPLL------LAICERRGQMVE-FLVKKKAN--------IHAV---
-DKMKR-------TA-LMLAVM--YESP--DVVRL-------------------------
--LL-QQG-ADI--------FSQD------VFG-WTAEE---YA-VI---S---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------G--------------
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-----------------------------

MPEDIDF-------DGQTLN--T------S------------------------------
---------------------------------------------------------EQP
HWYW--------------RL--WTCCLGYGC--------------LD--YQ-VDEYPVYL
IPYEPVGQ-----FQK---------------AASMGDL----------------------
ST---VEHFITSR-RYH--VD-KYDRR------------------NRTSL----------
----------HYAC--AHNHPEVVMLLIKSNCTINA--QDDEGCTPLIK-----------
-ATERNNLECVSILL-KHGADPHMADFT----GN--TALHYAV-YNGNRAIASELLKYKV
DINAITKH-G---FTPFS------LAVFEKREKMAE-FL---------------------
------------------------------------------------------------
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-----------------------------

------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------DKAFSEPWYN
IQPQDLRR-----LHM---------------AACLGQV----------------------
AK---VEDILSFAP-SM--MN-EKDCK------------------GRSAL----------
----------HLAC--AIGQTEVVRFLVHRKCKLNT--HDRERRTPLMK-----------
-AVQCQQEECVAILL-ESGANVHLTDVY----HN--TALHYAA-YHQNIQIADRLLAYGS
YIDPQNKN-G---STPLL------LAINENRKEMVE-FLLKNKAN--------RNSV---
-DKFNS-------IP-QQISED--KEEK--VLGDDSQNSSPG------------------
-----------------------N------MFH-FSST----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-----------------------------

-----------------------MED----------------------------------
--------------------------------------------------------EELK
RWPT--------------LRD----R---LC-------------------SDGFLFPQYP
IKPYHLKG-----IHR---------------AVFYRDL----------------------
EE---LKF-ILLT-RYD--IN-KRDRK------------------ERTAL----------
----------HLAC--ATGQPEMVRLLVSRKCELNL--CDREDRTPLIK-----------
-AVQLKQEACATLLL-QNGADPNITDVF----GR--TALHYAV-YNEDTSMIEKLLSHGA
NIEECSKD-E---YPPLF------LAVSQRKVKMVE-FLLKKKAN--------INAV---
-DYLGR-------SA-LILAVT--LGEK--DIVIL-------------------------
--LL-QHN-IDV--------FSRD------VYG-KLAED---YA-SE---AKN---RV--
--IFELIYEYERKK-HEELSINS-----NPVSSQ----------------KQPALKATSG
KEDSISNIATEIKDGQKSGTVSSQKQPAL-------------------------------
---------KDTSDKNDSV----SNTATEIKDEQKSGTV---------------------
--------------------------------LPAVEQCLNRSLYRP------DAVAQP-
--------VTEDEFAL--ESEIISKLYIPKRKIISPRSIEDA--LPPVEEAVDRCLYLLD
RFAQAVTKDKFALESEN------------------IS-EPYFT----NRRTIS-------
------Q---QSAENL-DAACGIDKTENGTLFEDHNV---DKEGK------------A--
------------------------------------------------------------
------------------------------------------------------------
-------------------------------LPA--------------------------
---------------------------T--------------GQKA--NVSPEQPPLF--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------THTVKD
RDHISTRFLGSTDSLTSSEESSERPPLSTLTL-K--------------------------
----------------------------------------EADPSSKAAMRRKDS-----
------------------------------------PPPGKVSSQKQPAEKAT----SDD
-KDSVSNI-----------------------------ATEIKEGPISGTVSSQK------
------QPAEKATSDEKDSVSNIATEI---------------------------------
-----------KEGQQSGTVS--------PQKQSAQKVIFKKKVSLL--NI------ATR
IMGGG---KS--GTVSSQKQPPSKATSDKTD----------SALNIATEIKDG-------
------LQCGTVSSQKQPALKAT---TDEEDSVSNIATE-----------------IKDG
EKSETVSSQKQPALK------------ATTDE---EDSVSIIA----------TEIKDGE
KSGTVTSEKRPGLKATSDEKDSFSNIT------RERKDGEISRTVSSQKPPALKATSDEE
DSVLSIAREEKDGEKS-RTVSSEQPPGLKATRDEKDSLLNIARGKKHGEKARRGNFE--K
RFNATTDEEDSVSIIAT---EIKDGEKSGT---------VTSEKR----------PGLKA
------KSDEKDSVLN--------IARGKEDGEKTRRVS----------S---RKKA---
-A---------L-------KATSDEKD-SF-SNI-TRERKDGEIS-----R---TVSSQK
PPALKATS---------------DEEDSVLSIAREEKDGEKSRTVSSEQPPGLEATR---
-----------------DEKDS-LLNIARGKKHGEKTRRGNF------------------
-----------------------------------------------------------E
KRFNATSDEKDSFSNITRE----------RKDG-------EIS-------------RT--
----------VSSEKPSGLKATSNEKDSLLNIARGKKHGEKTRRGNFE--KRFNATSDGK
DSFSNIT-RERKDGEISR------------------------------------------
-------TVSSHKQPA-----------LKATSDKEDSIPNIATKT-KD------------
EQISGTVSSQKQPALKATSDKKDSVSNIPT-------E--I----------KDGQHSGTV
-----------------------------------SSQKQ--PAWKATSVKKDSVRNIAT
------------------------EIKDGQIPGTGILEYTFNV------------MFNQI
EEKFTSPNKSAGVSPQK---------Q-------SAQKVIFKKKVSLSNIATRITGGWK-
-------------------------------SGTEYPENLPTLKATIEN-----------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------KD-SVL-NTATKMKDVQTSTPA
EQDLEMA------SEGEQKRLEEYEN-NQPQVKNQIH---------SRDD----------
-------------------------------------------------------L-DDI
IQSSQTVSEDSD--SLCCNCKNVILLIDQHE---MK--CKD--CVHLLKIKKT----FCL
CKRLTEL---KDNH-------------------CEQLRVKIRKLKNK-------------
--SSVLQ----KRLSEKE---EIKSQLKHETLE-LEKEL--CSLRFAIQHEKKKRRNVEE
LH-QKVREK----LKITEEQ------------------YRIEADVTKPIKPALKSAEVEL
KTGGNNS-----------------------------------------------------
---------NQ-VSETDEK-ED---LLHE------NRLMQDEIARLRLEKDTIKNQNL--
EKKYLKDFEIVKRKHEDLQKALKRNEETLA--------ETIACYSGQLAAL-T------D
ENTTLRSK-----------------------------------LEKQRESR---------
--QRLETEMQSYRCRLNAALCDH--DQSHSSKRDQE----LAFQGTVDKCCHLQENLNSH
-------VLILS--------------------------L-QLSKAESKFRV--LETELHY
TG-EALKEKALV-FEH--VQSEL--KQKQSQMKD-----IEKMYKS-GYNTM------EK
CIEKQ----ERFCQLKKQNMLLQQQLDDARNKA---DNQEKAILNIQA----RCDARVEN
LQAEC-RKHRLLLEEDNKMLVNEL-NHSKEKKCQYEKEKAEREV--AVRQLQQKRDDV--
--LNKR------SATKALLDASSCHCIYLENGMQDSRKKLDQMRSQ-FQEIQDQLTATVR
C-----------------------------------TKEMEGDAQKLEVENVMMRKIIKK
QDEQIERFE----KILQHS-----------------------------------------
------------------------------SLV-------------------S-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------AC--ANGHAKVVTLLINRKCQIDI--CDKENRTPLIQ-----------
-AVHCQEEACAVILL-EHGANPNLKDIY----GN--TALHYAV-YSESTSLAEKLLSHGA
NIEALDKD-N---NTPLL------FAIICKKEKMVK-FLLKNKAS--------IHAI---
-DRLRRY------ST-LMLAVY--YDSP--GIVNI-------------------------
--LL-KQN-INV--------FTQD------MHG-QDAED---YA-IS---RHL---TK--
--N--QLAHFHCVFLV-S----S----IFHELCVD-------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------SLPT-
--------SDDEDMSV--A------------T--------K-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------KCVP-------------K
D-------------VSQPLPGP--------------------------------------
------------------------------------------------------------
-----------------------------------SHEKGNR------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------IVNGKGE-----
------------------------------------GSFAQH-----PSLKPS----TKI
-EDPALKG-----------------------------AVQ--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------RKKVQTLREEQ-ALLVASEEEQERR
--------------ERTEKK-QPQ---------------VKEG--NNT---N---KSEKI
QV---------------------------------------------------------S
ENLCDRTSAAA-------------------------------------------------
----------A-------------------------------------------------
------------------------------------------------------------
----------------------------------DRLPQQRK------------------
------------------------------------------------------------
-------------------------------------------TW---------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------EMHPQQFPK------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------KLKE--ERDRCTLKQKNEEKANVNM
LY-KRNREE----LERKEKQ------------------HEKEVEAKQ-LEPTVQSLEMKP
NTARNTPN-Q--------------------------------------------------
------------DFHNHEEIKD---LMDE------ICILETDIAILRQEICTMKNDNLEK
ENEYLKDIKIVKERNAALEKIIKLNEE-IT--------KTAFQDQQELNDL-K------A
ENKRLNSE-----------------------------------LLKEKENE---------
--ARLEAEIESYQSRLATVISKH--SESVKTERNLK----LALQNTQDISE--QVKMSSD
ISEVEDKNEFLT--------------------------E-QLSKAQIKFNT--LKDKFHK
TR-DTLRIKSLA-LET--LQNDL--SQTQQQIKE-----MKEMYQN-AETKV------SN
STGEWNRVEERICQLQRENLWLEQQLDEVHQKE---DHKE-IVINIQR----GSI-----
---ES-RKKDLLLEEKNKKLMNDY-DRLKESLFQYEREKPERVV--SINEEKYFQTSR--
--KKI-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------MEVRGSFLA---------------------------------------
------------------------------------------------------------
------------------ACRRRMATWRKNR----------------D--KDGFSNPGYR
VQQKDLGM-----IHK---------------AAIAGDV----------------------
NK---VMESILLRL-ND--LN-DRDKK------------------NRTAL----------
----------HLAC--AHGRPGVVADLVARKCQLNL--TDSENRTALIK-----------
-AVQCQEEVCASILL-EHGTNPNVRDMY----GN--TALHYAI-DNENISMARKLLAYGA
DIEARSQD-G---HTSLL------LAVNRKKEQMVA-FLLKKKPD--------LTAI---
-DNFGR-------TAL-ILAAR--NGS-------------------TS----------VV
YQLL-QHN-IDV--------FCQD------ISG-WTAED---YA-VA---SKF---Q---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------AIRG--------------II
SEYK--------------------------------------------------------
------------------------------------------------------------
-----ANK-------------------------------RR-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------E---S----LQNSDS
EQDLEMTSEGEQERLEG-------------CESSQPQVE--------EKMKKCR------
---------------------------NKKIEVS---RNVHADDSDNY------------
---NDDVDELIH---------KIKNRKPD----NHQSPGKENGEF---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------DRLARKTSNEKSK---VKSQIYFRD--------
------------------------------------------------------DL-NDI
TGSSEKTSEDDELP--YSDDENFMLLIEQSG---ME--CKD--FVSLSKSKNA----TAA
CGRSIED---QKCY-------------------CEQLKVKFQKMKNN-------------
--ISVLQ----KVLSETD---KTKSQSEHQNLQ-GKKKL--CNLRFILQQQEEERIKAEE
LY-EKDIEE----LKIMEEQ------------------YRTQTEVKKQSKLTLKSLEVEL
KTVRSNSN-QNS------------------------------------------------
--------------HTHERERD---LWQE------NHLMRDEIARLRLEIDTIKHQNQET
ENKYFKDIEIIKENNEDLEKTLKRNEETLT--------KTITRYSKELNVL-M------D
ENTMLNSE-----------------------------------LQKEKQSM---------
--SRLETEMESYHCRLAAALCDH--DQRQSSKRDLQ----LAFQSTVNEWCHLQEDTNSH
I-------QILS--------------------------Q-QLSKAESTSSG--LETELHY
ER-EALKEKTLH-IEH--MQGVL--SRTQRRLED-----IEHMYQN-DQPIL------EK
YVRKQQSVEDGLFQLQSQNLLYQQQCNDARKKA---DNQEKTIINIQV----KCEDTVEK
LQAEC-RK----LEENNKGLMKEC-TLLKERQCQYEKEKEEREV--VRRQLQREVDDA--
--LNKQ------LLLEAMLEISSERRINLEDEARSLKKKLGQMRSQ-LQEMQNQRTEILR
R-----------------------------------AEELPDHMQKLKIENAVLKIRTKK
RADKIEQLQ----KMLVSS-----------------------------------------
------------------------------SSISQSLI----------FCHTEKEFY-FS
R-----------ISL-----------------------------VQNV------WEDQ--
--KW-IFSD--------FGIFVYT------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

MVA-----EVCSMPAASAVKKPFDFRSKMGKWC---------------------------
----------HHRFPCCRGSRKSNMGTSGDHDDSFMKTLRSKMGKCCHHCFPCCRGSGTS
NVGTSGDHDNSFMKTLRSKMGKW-CCHCFPCCRGSGKSNVGTWGDYDD---SAFMEPRYH
VRREDLDK-----LHR---------------AAWWGKV----------------------
PR---KDLIVMLRD-TD--MN-KRDKQN------------------RTAL----------
----------HLAS--ANGNSEVVQLLLDRRCQLNI--LDNKKRTALTK-----------
-AVQCQEDECVLMLL-EHGADRNIQDEY----GN--TALHYAI-YNEDKLMAKALLLYGA
DIESKNKC-G---LTPLL------LGVHEQKQQVVK-FLIKKKAN--------LNAL---
-DRYGR-------TA-LILAVC--CGS-A-SIVNL-------------------------
--LL-EQN-VDV--------SSQD------LSG-QTARE---YA-VS---SHH---HV--
--ICELLSDYKEKQMLKISSES--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------SNSEQ-----------
---------DLKLTSEE------------------ESQ------------RLE-------
--------------------------------VSENS-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------QSE--------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------KMSQEPEINK-----------
---DCDREVE--------------------------------------------------
---------EEIKKHG--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----SNP------------------------------VGFP------------------
------------------------------------------------------------
-----------------------------------------E-------NL---------
--------------------------------------------------TNG-------
------------------------------------VAA---------------------
---G---------NG---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------D-------------
--DGLIP----QRTSRKP---ENQ-----QFPD-TENEE--Y-HS---------------
------------------------------------------------------------
------------DKQNDTQKQLSEEQNTGISQDEIL-----TN---K--QKQIEVAA---
-KKMNSELSLS-----HKKEEG---LLRE------NSMLREEIAMLRLELDETKHQNQLR
ENKILEELESVKEKSDKLLKAIQLNEEALT--------KTSI------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------MRKLFSFGRRLG------------------------------
--------------------------------------------------------QALL
NS----------------------------------------------MD-QEYAGRGYH
IGDWELRK-----IHM---------------VAIKGDA----------------------
AE---VERCLTRRF-RD--LD-ARDRK------------------DRTLL----------
----------HLAC--AHGHVEVVTLLLGRRCLIDI--CDRLNRTSLMK-----------
-AVHCQEEACAIIFL-EHGANPNIKDIY----SN--TALYYAV-YNKGTSLAEKLLSHHA
NIKALNKE-G---NTPLL------FAINSGRQHVVE-FLLKNQAN--------IHSV---
-DNFRR-------TA-LMLAVQ--HSSS--SIISL-------------------------
--LL-QQN-INI--------FSQD------MFG-QMAED---YA-VC---CDL---RR--
--DAFLHVSFKL------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------G--------------
----------E----N--L-------------------------QGTFCNFF--------
-----------SFG-----------------------------DV-------V-------
-----------------------------LLYHQS--GVQWHDLR---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------S----------------------------------------------------
------------LQPPPPR-----------------------------------------
------------------------------------------------------------
----------------------------------------------------------FK
-QFSCLSL-------------------------------------------PK-------
------------------------------------------------------------
-------------------------------------------------SW--DNRHMQP
HPDDS-------------------------------------------------------
-------------L----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------YFK
------------------------------------------------------------
----------------------------SF-------ILTKHMDL---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------SAEHDLKVASEEKQERLER--SENKQPQDS---------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------QSYGKKKD---VMYG------NYMLKRDVAMLKQELYAIKNDSLRK
EKEYIHEIKSITEINANFEKSVRLNEEMIT--------KTIAQYSQELNDL-K------A
ENSRLNSK-----------------------------------LEKEKHNK---------
--ERLEAEVKSLHSSLATAINEY--NEILER-KDLE----LVLQRADDVYG--QEKMGSD
ISQLTDKNELLT--------------------------K-QLSKARVKFST--LKAKL--
-------EKTLA-LES--VQMDL--KQAQHQIKE-----MKQMHPN-EEAKE------SQ
STGTQNSLEERICQQELENLLLEQQ-LEDAHKE---GHNEEIVINIQG----GCL-----
---EN-GKEDLLLEEKNMELMNEY-NYFKEKL----------SV--IVRQLQEELADH--
--LKKF------SMSESPLEGTSYCHINLDE-TRTSKKKLFQVESQ-PEEKHEELG----
------------------------------------------------------------
-------------K----------------------------------------------
-------------------------------------------L---FELISSLDYN-VD
QIRKKNHELEEEATGCKKC-----LETTI--------------NMLNV------FGNE--
--DF-SCHGDLNTDQLKMDILSIILLMQFDDLMAEKEAVSSKCVNLAKD-----------
-NEVL--HQE-----KVQEKCRKLEKDKKMLEKEVLNLKTH---MEK-DMVELGKVQEY-
KSELDERAMQAI-EKLEEI------HLQEQAE-FEKQLEQ-LNKD-NTASL-K KKELKVK
DVECKF-SKMKTAYEE-----V--TTELEEYK----EAFAVALKANNSIS-EKIMKSDKK
IAVISTKLLMEKER---MKYFLS------TLPMRPDPEI---------------------
----PTSNPQTSNN C--KNSLTEMEPDCVEQIITETKKR-PPS-----VGR---------
ALILALGPSGVSDEDLGAPQFHSASPL-------------DTPRTTRTTPSWPCHQAQ-S
GSM-ITK--TQVQRQPPCTVDQ------HNMEEARAAGSQLPCSPRWHLGLGKSFLKQKL
ETLMSLEEKVNVASEQPWQPAASSHPTCLSATTVLQMEPHRGNEQQAQEQGVHCLWGSSP
CIRAPTALWASWVPRGRPQAIFRRTLFSSAE---REWENKIDGFECFTKKID--------
--NRLTCKQMMVMGFKK VHQKPSQERDPVMDLLVLSQGHQANIPDIIHIHKEALTKVTES
RQHVAEGKTEVQRLMMSESQEQDFFGHCG

------------------MKKLFGRRA-KG------------------------------
--------------------------------------------------------LSPL
GPAA----------------VRR--RVGLGR----------------EGA-GCSRSPRYR
VPDKDMGK-----IHK---------------AASEGDV----------------------
AR---VQHILMLGK-SG--VN-DRDKK------------------DRTAL----------
----------HFAC--AYGHPEVVTLLVERKCDIDA--RDSENSTALIK-----------
-AVQCQEEECAAILL-EHGADPNVMDAS----GN--TALHYAV-RGESISIAARLLLHSA
DTEMKNKD-D---LTPLL------LGVKENKQEIVE-FLVKKKAS--------IHAV---
-DELGS-------N--RCLLRI--ELI---------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------VFVKRRSN--TPGP--------------D----D--SWPTSDE---------
--------DDYNFDNKN-------------------VPKVNFTELWTAAQQSKKN----Q
ANYDFGKL------------------ENRITFDSGDSNNE--------------------
---------------------N-------------------EDVV---------------
------------------------------------------------------------
-----------------------------ETVPQ--------------------------
----------------------------------TSVRGQGSAPPS--FLSPDP------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------REGTAEPKMGKEE---------
---NGTDVIE----SASQE--------------QPNDDN-------------LTYADGWH
KSN----RSEMMSALGLGEDEDEESPWDSESV-SESLSLKCVG---------------HL
PEAAGGRGENRANG---Q------VEG----------------------------KSCIS
FFKSPGRMYFD-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------LTIKEQKWLNS-------------NENRQLQV---------EEKRVQK------
---------------------------YNKTEIS---ENLCNGAADRD------------
------VDGLNQ-----------QNGKAD----Q-GFSVKESKER-----------GW--
-----------GSPALPLKD-V-KKKD--QKWVFKESAPTPTTETA--------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------DSLQLKEDSSLSE-
------------------------------------IKDE---ASKQISVMD--------
------------------------------------------------------DL-DDL
TQSSETSSEGCELP--YPNYESILLQIEHLR---ME--CKD--TVCLLKIRDA----IHS
YKRLIEF---KRSH-------------------CELLTGKMKRMENK-------------
--FNRLQ----KELSESK---EAQSQLEHEKVE-WEQEL--STLRFALKQEEERRRSADQ
LH-EKVTDQ----LRKKEEQ------------------YDREVGIKQQLEISLRTLDMEL
KTVKNNLN-QVLEERNDTQRQLSREQNARILQDGIL-----ANHLCK--QKEIEMAQ---
-KKMTSEVSV-----SHEKEKD---LLHK------NQRLQDEIATLRLEMDTIRNHNQEK
EKKYLDDIKVENEKNDKLQRMIKLNEETFT--------KTVFQYNGQLNIL-T------T
ENTMLSSK-----------------------------------LENEKQNK---------
--ERLEAEIESYRSRLAFAVRDH--DEIQTSKRDLE----VAFQRARDEWLRLQDKLNFE
ISNLKDNNEILS--------------------------Q-QLSNTERKFNS--LEIEFHH
TR-DALREKTLV-LKQ--AWRDL--SQTQCQMKE-----VEHMYQS-EQGKA------NK
YIGKQESIQERLSQLQSENMLLRQQLDDANNKA---DNKEKTIVNIQD----QFHDIFKR
LQAES-EKQSVMLEDRNKELIDEC-NHLKERMCQYENEKAER EV--VVRDLQQELADT--
--LKKQ------SMSEASLEVSSRYRVNLEDETRDLKKKLGQIRSQ-LEEAQSQHTDAVQ
C-----------------------------------AERMQDLLNMCSLKAS--------
------------------------------------------------------------
------------------------------------------------------------
----------VYFCRFKKL-----LKMTK--------------KELNE------HKNK--
--EF-SLHQDIKTSQFENDMPTNVLKNKIDDLTAKLEIASSKCLHLDKK-----------
-NQLL--QEELLSMKTIQKRCGKLEKNKKKLEQEVVNLKSH---MEK-TLVELGQVEQY-
KREIEEKARQEL-VEKLKQVNL---FLQTQAV-SQENLEQ-LREQ-NTTSL RNQMELRIK
DLESEL-SKMKT-QE------DFDKLELQKYK----QLYQEEFKVRKSLS-NKLNRTNER
LEEASSKLLLEEQQ---NRSLLN------TLSTRPVVVLGA-------LIFKQ-------
-----------------VLIVNLMHQELEKSINRELKE----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

-------------------MKLFGFGSR--------------------------------
--------------------------------------------------------RGQT
VLG---------------------------------------------SIDHVYTGSGYR
IRDSELQK-----IHK---------------AAVKGDA----------------------
TE---VERCLAR-RSGD--LD-ALDKQ------------------QRTAL----------
----------HLAC--ASGHVKVVTLL---------------------------------
-AVRCQEEACAVILL-EHGANPNLKDIY----RN--TALHYAT-CSESTSLAEKLLSHDA
DIEALDKD-N---NTPLL------FAIICKKEKMVE-FLLKNKAS--------THAV---
-DSLRWY------ST-LMVAVH--YDSP--GIVNI-------------------------
--LL-KQN-INV--------FTQD------MCG-QDAED---YA-IS---RCL---TK--
--N--QLAHFHCVFLL-P----S----IFHELCVD-------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------SLPA-
--------LDDEVLSV--A------------A--------K-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------QCVP-------------E
K-------------VSEPLRGP--------------------------------------
------------------------------------------------------------
-----------------------------------SHGKGSR------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------IVNGKRE-----
------------------------------------RPPAKH-----RSLKPS----TEM
-EDPSVKG-----------------------------AVQ--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------RKNVQTLRAEQ-ALPVASEDEQQRR
--------------ERSEKK-QPR--------L------VKEG--NNT---Y---KSEKI
QL---------------------------------------------------------S
ENICHSTSSAA-------------------------------------------------
----------A-------------------------------------------------
------------------------------------------------------------
----------------------------------DRLTQQRK------------------
------------------------------------------------------------
-------------------------------------------IR---------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------KTYPQMNSLF-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------FNKMN---------------
----------------------------------FKINV--FICGCTLKQENEEKTNVNM
LY-KKNREE----LERKEKQ------------------YNKEVEAKQ-LEPTVQSLEMKP
KTARNTSN-Q--------------------------------------------------
------------DFHNHEEMRD---LMDE------NCSLKTDTAILRQEICTMKNDNLEK
ENKYLKDIKIAKETNA----CIKLNEEMIT--------KTAFWYQQELNDL-K------A
ENTRLNSE-----------------------------------LLKEKESK---------
--KKLEAEIESYQSRLAAAVSKH--SENVKTERNLK----LAVERTQDVSE--QVKMSSD
IS------EFLT--------------------------E-QLSKMQIKFNT--LKDKFRS
VRQDTLRKKSLA-LET--VQNDL--SQTQQQIKE-----MKEMYQS-AEAKL------SK
STGKCNCVEERICPLQRENPWLEQQLVDVHQKE---DHKE-IVINIQR----GFI-----
---ES-RKKDLMLEEKNKKLMNEY-DHLKESLFQYERQKAETVV--SIKEDKYFQTSG--
--KKI-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------MERLCAAAVKGQ------------------------------
--------------------------------------------------------TGPE
RPSP-------------------------------------------FSQLVYTNNDSYV
IHHGDLRK-----IHK---------------AASRAKP----------------------
GK---M-----------------RRRG------------------TRTAL----------
----------HWAC--ANGHAEVVTLLVDRKCQLDV--LDGKNRTTLMK-----------
-TLQCQREACANILI-DSGADPNIVDVY----GN--TAVHYAV-NSENLSVVAKLLSCGA
DIEVKNKA-G---HTPLL------LAIRKRSEQNVE-FLLTKNAN--------ANAV---
-DKFKW-------YK-GK------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----FNQ-------------------------------------------TV-------
------------------------------------------------------------
-------------------------------------------------CL--AEGTSEG
TPDEA-------------------------------------------------------
-------------APLAER-------------------------------------T-PD
TAE---------------------------------------------------------
------------------------------------------------------------
-------------------SLV--ERTPDE------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-----------------------------

--------------------------MFND------------------------------
--------------------------------------------------------YKPE
RWPT--------------LK--------------------------ERLCLDGFSFPEYR
IKLPHLRR-----IHR---------------AICYGRL----------------------
EK---LKYLLLTRS--D--VNKR-DRK------------------ERTPL----------
----------HLAC--ATGQPDMVSLLLSARCELNV--YDREYRTPLIK-----------
-AVQLRQEVCATILL-KNGADPNIIDFY----GK--TALHYAV-YNEDTSMIETLLCYGA
DIEERGKC-K---YQPLL------LAVSRAKVNMVE-FLLKKNAN--------VNAV---
-DTLNR-------SA-LILAVT--LGEI--DIVILLL-----------------------
---K-QHN-IDV--------FFRD------ACG-KTAED---YA-IE---TRN---KV--
--ILGLISEYKREKTSEELPINS-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------N--------------
----------PA--WA--T-------------------------EQD-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------SVSK
KKK---------------------------------------------------------
---------------KKKF-----------------------------------------
-WL---------------------------------------------------------
------------------------------------------------------------
-------------------HFFK-------------------------------------
------------------------------------------------------------
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-----------------------------

--------------MASAVRKIFG----VK------------------------------
---------------------------------------------------------EKT
PFGF--------------CDGPQMTVSEFFF--------------GE-----YPSYPKYH
TTYRPVGQ-----IHR---------------VAAEGDA----------------------
GQ---LEILITLG-KCS--VY-DRDYK------------------NRTAL----------
----------HFAC--VYGRLPVVNVLVNNNCEIDA--FDKNHITPLMK-----------
-SVQCWKQKCAAILL-EHGADPNIRDNS----GN--SALHYAV-YNGHEEMAALLLDYHA
DIEQKTKV-Q---FTAF-------------------------------------------
------------------------------------------------------------
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-----------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----MEILMTLG-QCS--VF-DRDHK------------------NRTAL----------
----------HFAC--VYGRLPVVNILVNNNCEIDA--LDKDHVTPLIK-----------
-SVQCWKLKCAAVLL-EHGADPNIRDYS----GN--CALHYAV-YNGHEEMASLLLKYHA
DIEQKTKD-G---FTPLL------LALRERKVGVAE-LFVKKGAD--------IHVV---
-DDMRR-------NT-LIYAIR--CGSK--NMATL-------------------------
--LL-QKG-IDF--------FYKD------TFG-WTALR---YA-IE---GHC---T---
--FRQMLLDFEENIHNNRNDSEPG--IEPKTSCILG-------------------KISS-
CPGPIPPMPTIKED--NYNSDA------------KVGCSLYFP----------LLFFFLA
W------IEKDLSP----------KPAPEVRE-----SVTNETIEVIELLPSV-------
-------PELEL-----------------------------MSVEEDMSDESENN--HVL
---EHLPQMNVGHLSD--AEDE-----------MEKN---DI--NRQVKDTF--IYCY--
-------------------------------------KDYCFVCNVLIMLNGL-------
-------------YLLVEPDLEVTSKEDHNKFDDR-----RN------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------IQTLRIYKDLPNVS-------------------------------------
------------------------------------------------------------
-----------------------------------GNVSATVDSR---RKTNG-------
--------------------------------------------------------QARG
-GPN--------IQLTSEE----EP--DSHNG-SGKNPSLNIFKQIQTQNVGYLSM----
---AKDQRGEETVVCV---------------EKGF--SKECP--QSKV------------
---------------------------------------------------PT----VEE
-NDSVPNK-----------------------------DADIKHGKWFQEGELILIILW--
DS----------------------------------------------------------
--------------------------------ILINYIDFSAESSGK---VA--SEEEQK
CHDDPE---KEERVG-VLKQPQPRDIA---------------------YL--SVANDESR
ENTREGQEEE--------------------------------------------------
------------------------------------------------------------
-------------------------SDVLL------------------------------
---SSEEEKEWPDDCE-GEHLKQPQPKGTAH-SSMAK-----------------------
----------------------DERGAD-------------VISDQEKGL-SPEYPELKD
AIEKQDSVLTKDSTVN--------QEKSLMTGAETVQLRLEEEQTEWCGSN---KKQRKQ
-----LQPKRND-------QVSLDPEK-HV-KNSGVAEERGATTI-------QPGPKTEQ
TGRFVSDKKQRKPIFERFQPKWSAQAFMGPEE-SGENTGATEEKGATTVQPRPKTEQAGR
--------------FGRDKKRRKSIF-ERFQPTWSTRLFMGPEESGEN---T---GAVEE
KGATTVQLR-LEEEQTKWNGSDKK-------------------PWKP-VFERFH------
--SKWSARVSVGPGESGEN----------TGAAVKKGENSVN------------------
----------KGSWQ-----GVTG-S-SCRHNLE-------------QLQPKWSDRV---
----------------CV---------ETK----------QGGDNTD----------A-A
Q----MTCKSFVY---------------KTTIKEQDSAPAEDSTT-NHEI----------
LMSGKL-MSKYPCKSLLSFIFQHIFKHLQPKGKDNL-------SMTMDQRSKN-IVSGE-
--------EKAEPDLEVASGDDQNRCYR--SESDQSL--------VCRYLSLSISLNIV-
------FS-FK-YCIIE----------QTGLPYS--------------------------
-----------------------THGA-------SNG-------VDI-------------
----------------------AKYPC----------EAATSFTASADAG----------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------I---AASALDE-LVLQRIPGEIKNQRFLIK-
---------------------EHAMH-DGPRKKTSKKKHK---ITKEIRA----------
-------------------------------------------------------M-GDT
TQSS-------------------------KS---VS--EDD--YGSSLKIQDS----LNL
YNALVDL---KKMN-------------------KIL-TKNNKKLENK-------------
--NNALQ----KEISETR---EEISNLQDEIVK-WTEEF--RNLRFTLRKELEETRNILC
FY-KNIKKH----LSEIEKQ------------------FNERVAVTQ-LGIYLRTRDMGL
ENETNSLK-EFLE-----------------------------------------------
---------------AQDAYIE---TLKI------VQKLKDHLQRVELEHSKLKVKAKDQ
AKKI-EE----------LRGCLHNSCEKLE----------QDEKLTQAG-----------
----AQET-----------------------------------LGELCENT--I----HS
PVNQTGIQTQSRWSEPTQMKTVQ--ESNISAPESFE---------------------QQC
IEELRINNALLCE---LYRNRRLSESCAQVHISVEQG-T-PLNTSGTRFALESPCVASTC
PRRHFLPCENMT-LPG--NPSIQ-----TCH--H-----MEDEE-----KSI------KE
LTKLKQYLRCNLYQQQQKNDELEKEIL-----------------------------RIKK
FL-KM-RKIGH-------EIGECS-SHGNSRTGHF-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

MMA-----EVGSMPAASSVKKPFGLRSKMGKWC---------------------------
----------CHCFPCCRGRGKSNVSTSGDHDDSAMKTLRSKMGKWCCHCFPCCRGRGKS
NVGASGDHDDSAMKTLRSNLGA--------------------SGDHDDSTLRSNVGPRYH
VHREDLDK-----LHR---------------AAWWGKV----------------------
PR---KDLIVMLRD-TD--VN-EKDKQK------------------RTAL----------
----------HLAS--ASGNSEVVKLLLDRRCELNV--LDDKKRTALTK-----------
-AVQCQEDECALMLL-EHGTDPTIPDEY----GN--TSLHYAI-YNEDKLMAKALLLYGA
DIESRNKL-G---LTPLL------LGVHEQKQQVVK-FLIKKKAN--------LNAL---
-DIYGSSYLCHFGTA-LILAVC--CGS-A-SIVSL-------------------------
--LL-EQS-IDV--------SSQD------LFG-QTARE---YA-IS---SHH---NV--
--ICQLLSDYKEKQMLKA-SEN--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------SNPEQ-----------
---------DLKLPSGE------------------ESQ------------RLK-------
--------------------------------GSQNG-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------QPE--------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------KMSQEPEINK-----------
---DGDREVY--------------------------------------------------
---------LRM------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------K--KHG--STHVG------------
-------------F-------------------PENLTHGAAAGNGD-------------
--DGLIP----PRKSRTP---ESQ-----QFPD-TENEE--Y-HS---------------
------------------------------------------------------------
------------DEQNDTQKRLSEEQNTGILQDEIL-----IH---K--EKQKEVAE---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

-------------------MKFFGFGSRRA------------------------------
--------------------------------------------------------QVVR
DS----------------------------------------------TD-QVYTGSGYR
IRDADLRK-----IHR---------------AAVKGDA----------------------
AE---VERCLARRS-RD--LN-ARDKQ------------------RRTAL----------
----------HLAC--AHGHVEVVSLLVDRKCQIDV--YRSQ--LFRHD-----------
-AVHSQEETCASILL-KHGANPNLKDSY----GN--TALHYAV-YNDATSLAEKLLSHDA
DIEALDKV-G---NTPLL------FAVICKKEKMVQ-FLVKRQAN--------VHAV---
-N---R-------SA-LILAVH--HGLP--DTVNL-------------------------
--LL-QQN-INI--------FSQD------KYG-RDATD---YA-IS---CDS---TR--
--IKNQIMEHKKKILEKDKPGKT-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------S--------------
----------DL--EF--L-------------------------I---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------SLNFLVDSEEEQERLER--SEKKEP------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------E-DFHSHEKMK---DPMHE------NGILKRDIAMLREEICTLKNDSLKK
ENKYFKDFEIIKEINARLEKSNKLSEEMIT--------KILSQYRQQLKDL-Q------A
ENTSLKSE-----------------------------------LGKEKEDE---------
--ERLEAETESYQSGLAAAIREH--NQRVEAERDLK----LSLQRTQDISL--QINMSSE
L-----KDEFLK--------------------------E-KLSKTQIKFNT--LKDKLCK
IS-DTLREKTLA-LET--AQNQL--RQTQQQIKE-----MKEMYQN-ADAKV------SK
STGKRNYVEERICELQRKNLWLKQQ-LDDAYQK---GDNEETIINIQG----GFF-----
---ES-GKKCLLLEEKNKKLMNEC-SRLKERLFQHEKEK AVD-----VRQLQQQLADS--
--LKNI------STSELPLEGTSRCHINLDE-TQASKKKLFQVESQ-PEEEKKELR----
------------------------------------------------------------
-------------K----------------------------------------------
-------------------------------------------R---SELISSLKYN-MD
QIRKKNDELEKERAGYKKL-----LEMTK--------------CLLNE------FGNE--
--EL-VFHGDLETDQLEMNITKLKH--KFDDLTEELGAVSSKCLYLAKN-----------
-NQVI--QQELISMKDVQQKYEKLEEVNKTLEQEVVNLKTH---KEK-NMVDLSELEEY-
KLQIEERTRQER-KKLEEI------GLQKQAE-YEKHLEQ-LKKN-YMASV-NKIDLIQK
DAKYQF-CKMKTAYEE-----A--TTELKEYK----EAFAIALKANRSMS-KKVKKSNKI
ITRVRSMLHMENRQ---TTPFLS------PPPVRPDPGSPGVGNLNSMG-LHRKYIPKKP
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------MKKIF------T------------------------------
---------------------------------------------------------GQS
PL----------------------GFLGFRH--------------AS--A-ESQEMPSYL
SGYKPVKR-----MHK---------------AASVGDI----------------------
TQ---VQRMLIFE-DVD--VN-ITDRK------------------KRTAL----------
----------HDAS--AHGQPEMVSLLLWYECNIDV--CDRDKSTALIK-----------
-ATQCQHEKCVHILL-ENGADTNATYAD----QN--TALHYAV-HNN-TSIAAELLGHNA
DTKVKAKG-G---YTPLI------LAVLENKQEIAE-LLLKKEVD--------INAL---
-YHCNR-------SA-LIRAVR--AQSK--NMISL-------------------------
--LL-QQG-AND--------SLVD------VFG-ATAQS---YS-VF---ESF---K--V
LSN---------------------------------------------------------
SPGPRCPEPTIKGDAYD-FD----------TKNACTPRSCPIKESKQQIAELPAKEKA--
----------------------------------------K-AHAEETLGRCKW------
------------------------------------------------------------
------------------------------------------------------------
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-----------------------------

MVA-----EVGSMPAASSVKKPFGLRSKMGKWC---------------------------
----------CHCFPCCRGRGKSNVSTSGDHDDSAMKMLRSKMGKWCHHCFPCCRGSGKG
NVGTSGYHDDSAMKTLRSKMSNH-DESSV----KTLRSNVGAWGDYDD---SAFMEPRYH
VHREDLDK-----LHR---------------AAWWGKV----------------------
PR---KDLIVMLRD-TD--VN-EKDKQK------------------RTAL----------
----------HLAS--ANGNSEVVKLLLDRRCELNV--LDNKKRTALTK-----------
-AVQCQEDECALMLL-EHGSDPNIPDEY----GN--TTLHYAI-YNEDKLMAKALLLYGA
DIESRNKH-G---LTPLL------LGVHEQKQQVVK-FLIKKKAN--------LNAL---
-DIYGR-------TA-LILAVC--CGS-A-SIVSL-------------------------
--LL-EQS-IDV--------SSQD------LSG-QTARE---YA-VS---SHH---NV--
--ICQLLSDYKEKQMLKVSSEN--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------SNPEQ-----------
---------DLKLPSGE------------------ESQ------------RLK-------
--------------------------------GSENG-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------QPE--------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------KMSQEPEINK-----------
---DGDRKVE--------------------------------------------------
---------EEMKKHG--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------KNLTNGAAAGSGD-------------
--DGLIP----PRKSRTP---ESQ-----QFSD-TENEE--Y-HS---------------
------------------------------------------------------------
------------DEQNDTQKQLSEEQNTGILQDEIL-----IH---K--EKQIEVAE---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------MKKIFGFGSKKG------------------------------
--------------------------------------------------------ESPL
GSSI----------------SPRRDSAGVRQ----------------ENSKSVNSQPGYH
IRDKDLGK-----IHK---------------AASVGNV----------------------
AK---VQQILLLGK-NG--LN-DRDKT------------------NRTAL----------
----------HLAC--ANGHPEVVTLLVERKCQLNL--CDSENRTALIK-----------
-AVQCQEEECATILL-EHGADPNLTDVS----GN--TALHYAA-CGQNISIAAKLLSHGA
NIEARNKN-D---LTPLL------LAVSENKQQMVE-FLVKKEAN--------IHAV---
-DKLCS-------NR-KLISEY--KEEK--RPKNSSQNNN-LVDESSDE-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------DSLSRLSN--KPGI--------------D----D--SWPTSDD---------
--------DDLDLGIKN-------------------VPRPNLTKLITASQQSRK---TME
EKPNIVRP------------------EKRTLFEDSNSDSE--------------------
---------------------V-------------------ADVV---------------
------------------------------------------------------------
-----------------------------ETLPK--------------------------
----------------------------------PSFKVQGFSHPA--FPSPDPP-----
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------EGATKPAIGKRE---------
---NSIDIIE----SAPRD--------------ETNNDN-------------LTYVDGAH
KNN----RSDMMSALGLGEEEGVESPWDSESV-SESLPQKYVS---------------HL
SGATDEKGENILNG---Q------IED----------------------------VFYIP
SCMSESRNVKMAKLEDTRNV--------------GIPVAHMDSPEKYPHLKPT----TEM
-RDSAPDK-----------------------------AAGTK------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------DV------------------
---------------------------------------------QTPK-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------S
EVDLKMTSEEEQERLDE-------------SENNQLQVE--------EERKKFR------
---------------------------SNELEVS---ENLDDTAAAAS------------
-----GADGLIR---------QEKSGETG----HQQFSVKENEDS---------------
---------DSSGPALLMKE-VKKYES--RNWSSKESVTAPALQKAALL-----------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------TGVL-HVNDDSSLSE-
-------------------VDQDEG---RPTKKTSDEKSK---IKKQINSAD--------
------------------------------------------------------DL-DDL
SQSSETASEDCALP--NSNYKNSMLLIEQLG---MD--CKDIDSVSLLKIQDA----ILS
YERLVEL---KKKH-------------------CELLTGKIKKMENK-------------
--VSGLQ----KELSETK---EIKSQLEHQKVE-WEREL--CSLRFTLKQEEEKRRNADM
LY-EKIRDQ----LRRKEEQ------------------YSKEVEMKQQLELSLRTLDVEL
RAVRNNLN-QVIEERNDTQRQLSREQNARILQDGIL-----TNHLCK--QKEIEMAQ---
-KKTMQNS--E-VSNSHEKEKD---LLHK------NHMLQDEIAMLTLEIDTLKNQNQEK
EKKYSDDIEIVKEKNDDLQKTLKQT-----------------------------------
ENTMLNSK-----------------------------------WENEKQNK---------
--ERLETEVESYRSRLAAAIHDH--DQSQTSKRDLE----LAFQRARDEWFRLQDKMNFD
LSNLKDNNETLS--------------------------Q-QLSKAESKFNS--LEIELHH
TK-DALREKTLV-LER--VQRDL--SQTRCQLKE-----IEHMYQN-EQGKV------NK
YIGKQESMEERLSQLQSENMLLRQQLDDAHNKV---DNKEKTVINIQD----QFHDIVKK
LQVES-EKQSLMLGERNKELINEC-NHLKEQMYQYENEKAERET--VVRQLQQELADT--
--LKKQ------SMSEASLEVTSRYRINLEEETQDLKKKLGQIRCQ-LEEVQDRHAEAVR
C-----------------------------------AEKTQEHLEKIEIENTKLKVTIKK
QTGKIEHLQ----KNLLCT-----------------------------------------
------------------------------SSSEDEKG-QLKKL---IELKQSLEYR-LD
QEMKKNSELEKEITG---------------------------------------------
------------------------------------------------------------
--------------KAVQKKCEKLEKNKKKLEQEVVNLRSH---LEI-NMIDHGQIEQY-
KWEIEERARQDV-VEKLKEVNL---FLQTQAA-SQENLEQ-LREN-NNASIRSQMELRIK
DLESEI-SKMKTSQE------DSNKTELEKYK----QLYLEELKVRKALS-NKLNKTNER
LAEISTKLLVEKQQ---NRSLLS------TLTTRPVLEPPCVGNVNSSLVLNRNLIPREN
LAI-PTSSPRPSNNS-METYLTKMQQELEKNITRELEEA-AAE-----FES-----G---
--------------------SCRASPLGST---------DES----NLNQDLVLKTSQEY
VQILKKN--YMI------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

--------------------------MFDD------------------------------
--------------------------------------------------------YKPE
RWPT--------------LK--------------------------ERLRLDGFSFPEYR
IKLSHLRR-----IHR---------------AICYGRL----------------------
EK---LKYLLLTRS--D--VNKR-DKK------------------ERTPL----------
----------HLAC--ATGQPDMVSLLVSARCELNV--YDREYRTPLIK-----------
-AVQLRQEVCATILL-KNGADPNITDFY----GK--TALHYAV-YNEDTSMIETLLCYGA
DIEERGKC-G---YQPLL------LAVSRAKVNMVE-FLLKKNAN--------VNAV---
-DFLNR-------SA-LILAVT--LGKI--DIVILLL-----------------------
---K-QHN-IDV--------SSRD------AYG-KTAED---YA-IE---TKN---EV--
--IFRLISEYKREKTSEELPINS-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------N--------------
----------PA--WA--T-------------------------EQD-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------SVDY
YEKKS-------------------------------------------------------
-------------MVIQRF-----------------------------------------
-WL---------------------------------------------------------
------------------------------------------------------------
-------------------HFLK-------------------------------------
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-----------------------------

------------------MKKFFTFWRR--------------------------------
--------------------------------------------------------KHEP
-------------------VSPSSDL-----PV----------GRARTG-THHLTQPGYN
LRDKDLKK-----LHK---------------AASVGDL----------------------
EK---VKKYLQRKK-HD--VN-IRDRE------------------YRTPL----------
----------HLAC--ANGHSNIVSLLIEKQCKINV--CDRENRSPLTK-----------
-AVQCAKEDCATILL-GHGADPNLVDLD----GN--TALHYAV-CGQSISLVEKLLEYKA
NLEDQNKD-G---YTPLL------LAITENNAKMVE-YLLKRGAD--------VNAS---
-DKNQR-------TA-LMIALS--DEPT--DLVSL-------------------------
--LL-QQE-VDL--------FCQD------IYG-FTAEE---YA-SF---NGF---TV--
--YHQLIANYGREKKV--EQMSN-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------S--------------
----------ED--TA--L-----------------------------GNES--------
-----------D------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--IEELK-----------------------------------------------------
------------------------------------------------------------
-------------------------------------------------EV--MDESSEE
--DPL-------------------------------------------------------
-------------ADLNRT-------------------------------------SNKL
CWV---------------------------------------------------------
------------------------------------------------------------
-------------------TVPGGQ-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-----------------------------

------------------------------------------------------------
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------------------------------------------------------------
-----------------------------------------------TAL----------
----------HLAC--ASGQSSVVALLVQWKCDLNA--RDEESKTALIK-----------
-AVQCRKEMCVTILL-KQGADPNLEDNC----QN--TALHYAV-LAEETSIAAELLRCNA
NIEAINKD-K---FTPFL------VAIRENKEEMVK-FLIDSGAN--------VHAI---
-DKLES-------LY-QLIIDY--RDGN--IPATPPQSSDLERTGAEADLVVD----VSP
S--------HEDTSVIRVSPKYDT------DDS-RPTSDDD-LD-LA---PK--------
------------------------------------------------------------
------------------------------------------------------------
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-----------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------WQ---HLWGDGFSCCEYE
IKSSHLRK-----IHR---------------AVVHCKL----------------------
EK---LKTILI-RE-NC--IN-DKDKK------------------NRTAL----------
----------HLAC--ATGQSQMVKLLVENNCQLNL--LDSECRTPLIK-----------
-AIQLKQVSCATILLE-NNADPNIMDYY----GR--TALHYAV-YNEDTAMIESLLSHGT
DIERSSKR-F---RFLFFFLENAMHKINKG-NFILI-LLLKTFTKYTKLLEYFKQYQ---
-DIN--------------------------------YPIH--------------------
----------FS--------SATS-------D----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------KKDSVSNT----------------------------------------------
---------ATEIKDGD-KSGTGNF----------------------ATSD---E-----
------------------------------------------------------------
-----------------------------------------KDSVSNISVKYTLCA----
-DCC--------------------------------------------------------
-------------------------------------------ASNPIQATSDKKDSVSN
TATEIKDGDKSGTGNFET------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------MLR-------------------------
------------------------------------------------------------
AAR----EKDQITSLSKGN--PSDSQWISQQK-PYKPEETGVHDKK-----------DSV
LNIA-----TEIKD------------------------------------E---QQ----
------------------------------------------------------------
-------------------------------------------SG-----TGNFSMKY--
-----TLYI----------DSFV-S-------------TPIQAT--SDKKDSVSN-----
---------------------------------------ITTEIK----------DGRK-
-S----------------------------------------------------------
------------------------------------------------------------
---------GRVSSQKQRAWK---------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------TT---SDEKD
SVVN-----------IATETKDVQKS----G-----------TGS---------------
---------------------------TSRRQC---------------------------
--------------RPD--------------------------------TAPWSLG----
--------------TGC----------------------CQRRR----------------
-----------------------------PSGTTGYSVSNIATEI-KDGQ----------
--KSETG-----------------------------------------------------
--------------------------------------------NFALLKRKVSLLNVAT
G-----------------------------------------------------------
-----------------T--------A-DGQ-----------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------KSGA
-------------------------------------------E----------------
--------------QDLEMASEGE---QKKLEEYENNQAW--------------------
---------------------------------------------MKNQIHFRDDL-DDT
IQSSQIASEDDDSL--SSNCKKVILLIDRHG---MQ--CK--DCVHLSKIKNA----IYL
RERSIDN------H-------------------CERLTRKIQKMKNK-------------
--ISVLQ----KRLSEEK---EIISQLEHEKPE-WEKAL--CSLRYAILQEKEKGRNSEK
LH-EKVGEK----IQKIEEQ------------------YAIDAKEIKQLKLAIKSLEVEL
ETVGNDSN----------------------------------------------------
----------Q-ISDSHEKEED---LLHE------NHLMQDEIARLQLEIDTLKNQN--L
EKKYLKDIEIIKGRNEDLRKTLKWNMETLT--------KMMACSSGRLTAL--T-----D
ENTMLRSK-----------------------------------LEKEKESN---------
--QRLETEIESYRCRLNAVLCDH--DQSQSSERDQE----LAFQGTVDKWCHLQENLNSH
-------VLFLS--------------------------Q-QLSKAESKSKG--LETELCY
TR-EALKEKTLV-FEC--MQRDL--NQTQCQMKD-----IEKKYKN-CQDKV------EK
CIEKQE----RLCQLHRQSMLLQKQLNDAHNKA---DNQEKTLINIQA----KCDARVQS
VQAEC-RKRSVLLEEENKRLINEV-NHLKEKQCQYEREKAEREV--LVRQLQQKRVDA--
--LHKE------STSKTLMDASLRRSVHLESELEDSKKKAGQMRSQ-FQEIQDQLTATLR
CTEK-----------------------------------MQGDVKKLEIENSVRRSIIKK
QDDQIEQLQ----KIMQSSTSLWCH-----------------------------------
------------------------------V-Y---AQ----------KVSDFRAF----
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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-----------------------------

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--------------------------------MNEVVTIKFPFKTGKERKQH---TSNKM
EGAE-----------NIYDDAAAAAAAPALG-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------TA--LAVAA--------AAAAAAAPAPAAGL-IQQR----------
--KTGK------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------TDNHLFPTTQNEDS---------------
-------DS--NDPGLSIME-IKKDKNV--KWASKASVITPGF-----------EE----
----------------------ADSLTGSLL-----------------------------
-----------------------------------RV--SNDN----S------------
------------------------------------------------------------
----------------LSKMDQDE---RRPAKKTSKEKNK---VKKQVNSAE--------
-------------------------------------------------HLDDEHL-DDL
TQSSEAASEDCKLQ--YSDYKSSLLFI-ELG---MD--CK--DSVSVLTIQNA----ILK
YKRSIEL---KRKD-------------------CEQLTRKILQVEYK-------------
--VNGLE----QLLSETK---EMKSQLEHQKVE-WEREL--YSLRLTLKQEKEKRRSAEI
LY-INIKEQ----LRSKEE-----------------------------------------
------------------------------------------------------------
--------LSE-VSPPHEKEKG---LLHE------NRMLQDELAMLRLEIDTIRNQKQ--
EKRYCEDTETEKEKNDSLQNAIKLNE----------------------------------
---------------------------------------------DEKLNR-----------ERLEAKLQSYRARVATAIQDR--DQSQASKRDLE----LAFQRAKDEWCHLQDKMNFEMSNLKDNNEVLS--------------------------Q-QLSEVESKLNA--LEIELQYTR-DALREKTLA-LEH--LQRNP--KQTQGQKKE-----IEQKSQN-EQGKV------NEYMGKHESLEEKLSQLQSENMLLREQLDDAYSRV---ECKEKTIIYLKD----QVQVIVRMVRVAG-EKRALQLRERNKELINKC-KQIMERAFRYEDEKEERER----------------------------------------------------------------QEAKELQTKVV----------------------------------------------RLEVENAELKVTVKEQAGQIEQLQ----KDLLSSSSCGDE-----------------------------------------------------------------N---------------------LLQFR-LDQEAKKNEELEKENTGLKNH----LINMLR--------------RILSK------YENGE----L-PFYGDLKTSQTEMEIQINMLRQK------------------------------------------------------------------------------------------------------------------------RQAA-SQENLEQ-LRAS-HDASISSQVALRIKELESELQSQIRNSQE--------LKIELEKYR----QLYLEESEMRMSLT-KKLSKTNERLADISTKYLVERQQ---NRPFHS------TLTMGPVLEGPSVGNLTSSLLLDRNVTPRENVMI-PTSRPQTSVSS-IETHLFKMQQMLEDSIIRELKEV-AAQACVTTYSG-----K-----------------------RL------------------------------------PFLHILTNICHFLICSF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DEKLNR---------
--ERLEAKLQSYRARVATAIQDR--DQSQASKRDLE----LAFQRAKDEWCHLQDKMNFE
MSNLKDNNEVLS--------------------------Q-QLSEVESKLNA--LEIELQY
TR-DALREKTLA-LEH--LQRNP--KQTQGQKKE-----IEQKSQN-EQGKV------NE
YMGKHESLEEKLSQLQSENMLLREQLDDAYSRV---ECKEKTIIYLKD----QVQVIVRM
VRVAG-EKRALQLRERNKELINKC-KQIMERAFRYEDEKEER ER----------------
------------------------------------------------QEAKELQTKVV-
---------------------------------------------RLEVENAELKVTVKE
QAGQIEQLQ----KDLLSSSSCGDE-----------------------------------
------------------------------N---------------------LLQFR-LD
QEAKKNEELEKENTGLKNH----LINMLR--------------RILSK------YENGE-
---L-PFYGDLKTSQTEMEIQINMLRQK--------------------------------
------------------------------------------------------------
----------------------------RQAA-SQENLEQ-LRAS-HDASI SSQVALRIK
ELESELQSQIRNSQE--------LKIELEKYR----QLYLEESEMRMSLT-KKLSKTNER
LADISTKYLVERQQ---NRPFHS------TLTMGPVLEGPSVGNLTSSLLLDRNVTPREN
VMI-PTSRPQTSVSS-IETHLFKMQQMLEDSIIRELKEV-AAQACVTTYSG-----K---
--------------------RL------------------------------------PF
LHILTNICHFLICSF---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------MKRIFGLGKRQI------------------------------
--------------------------------------------------------DPSL
SSQP------------------------------------------------AAYGSGHR
VWDRDLGK-----IHK---------------AASRGQV----------------------
AK---VQQILLLGK-NG--VN-DKDKK------------------NRTAL----------
----------HLAC--ANGHAEVATLLAERKCHLNI--YDGEYRTPLMK-----------
-AIQCQEEECVTILL-HHGADPDITDAS----GN--TALHYAV-QGQSIKIAEKLLCHKA
DIVARNKD-D---LTPLL------LAIREKKEQMVE-FLTKKGAN--------IHAV---
-D----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------KAKRLSN--SPGS--------------D----D--SWPAS-D---------
--------EELDFDSKN-------------------LPNPSLTKLMTAFQQSRK---NIE
ANGGIVRP------------------QNKTLLEDNSSDSE--------------------
---------------------H-------------------EDVV---------------
------------------------------------------------------------
-----------------------------ETLPE--------------------------
----------------------------------WPVRVQGISPAA--FASPEPLLKPPL
E-----------------------------------------------------------
---------------------------------------SSAVH----------------
-----------------------------------GATKEGTTKPAIVTKE---------
---TGIGITE----SALRE--------------LMNNEN-------------MAFVVGVH
KND----RSDMMSALGLGEDEDRESPRDSESI-SESVPEKSFA---------------YL
SEVTDQRGKNILNG---Q------IE----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------G
EVDLKRTSEEEKERLDG-------------GENNQPQVE--------EERKNPK------
---------------------------GSDVEVP---ENLCTTSAEV-------------
-----IEGGLSQ---------QRMSEQRD----SQQFALKD-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------NDSNKARDGLFHLWEEMKVD
VSNLKHYTEILS--------------------------E-QLSKSASKFSI--VKLELYQ
TK-DALRKKNLV-LER--VERDL--RQAQCQMKE-----VEHMYES-EQGKV------SK
YIGKLECLEERLSQLQSENILLRQQLDDAHKKA---ASEEKTVIDIQG----QFQDVTKN
LKTES-EKQSL-LEEQNKELINEC-NRLKKQIHQYENEKLEREV--VVRQLQQELADS--
--LKKQ------PMSEASLEVKSHYHINLD-ETQDVKTKLSQIICK-LQAAQAHLPKTVP
S-----------------------------------AERTQ---QQLEIENTRLKVTIKK
QTSKIEQLQ----KNLLGT-----------------------------------------
------------------------------NLSKEEKE-QLKKL---TELKQSLEYR-LD
KEMKKNGELEKEIIGFKKL-----LKMTR--------------KELNK------YENG--
--EL-SLCGDLKPKQIEMDSQITMLKLQTDDLIAKLETSSSKCLHLDAK-----------
-NQDL--QQELLSMRAIQKKCEKLQKNKKKLEQVVVNLRSH---VEM-NMLELG-VEQY-
KREIEERARQEI-VEKLKEVNL---FLQIQAA-SQEKLEQ-LREN-NNTSMRQQMELRIK
DLEAKL-SEMKISQE------DSNKSELERYK----HLYLEELKVTTLLS-KKLNETQEQ
LAETTTKLLMEKLR---NRYLVS------PLTVTPVLEPSCAGNLNNQSVLNRNLIPRQN
IVI-PSSIPRPSSNS-METTFTKLQQELERNITRETK-A-AAD-----FES-----G---
--------------------SYR-VSLGST---------DES----N-NQDLVLKTTQEY
VEILKKK--YMI------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------MGVGGSFLGT--------------------------------------
------------------------------------------------------------
-------------------CGGCMAPWRENR----------------G--KDGFSNPGYR
VRQKDLGM-----IHK---------------AAIAGDV----------------------
NK---VQESILLGL-ND--VN-NKDNK------------------NRTAL----------
----------HLAC--AHGHPGVVADLVARKCQLNL--TDSENRTALIK-----------
-AVQCQEEVCASILL-EHGADPNVRDMY----GN--TALHYAI-DNENISMAGKLLAYGA
DIEAKSQD-E---YTSLL------LAINRKKEQMVT-FLLKKKPD--------LTAI---
-DNFGR-------TAL-ILAAC--NGS-------------------TG----------VV
FQLL-QHN-VDV--------CCRD------ISG-WTAED---YA-IA---FNF---Q---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------AIRR--------------LI
SEYK--------------------------------------------------------
------------------------------------------------------------
-----ANK-------------------------------RR-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------K---R----LQNRNP
EQDLEMTSEGEQESLEG-------------CESSQPQVE--------EKMKKCR------
---------------------------NKKMEVL----NVHADDSDNY------------
---NDDVDELTH---------KIKNRKPD----NHQFPRKENDKF---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------DRLARKTSNEKSK---VKSQIYFKD--------
------------------------------------------------------DL-NDV
TGSSIKTSEDDDLP--YSDDKNFMLLIEQHG---ME--CKD--FVSLLKIKNA----IAA
CERSIEH---KKCN-------------------CEQLKVKFQKMKNK-------------
--ISMLQ----KELSETD---ETKSQLEHQNLE-CKQKL--CNFSCILQEEEEKRRKAEE
LY-EKDTEE----LKIMEEQ------------------YRTQTEVKKQLQLTLKSLEVEL
KTVRSNSN-ESS------------------------------------------------
--------------HTHEKERD---LWQE------NHLMRDEIARLRLEIDTIKYQNQET
EKKYFKDIEIIKENNEDLEKTLKLNEETLT--------KTITRYSKELSAL-M------D
ENTVLNLE-----------------------------------LEKEKQST---------
--QRLKTEMESYPCRLTAALHDH--DQCLSANRDRQ----LAFQSTVNEWCHLQENINSH
I-------EILS--------------------------Q-QLSKIESTSSG--LETELHY
ER-EALKEKTLA-IEH--MQGVL--SRTQCRLKD-----IEHMYQN-DQPIF------EK
YVRKQQSVEDGLFQLQSRNLLYQQQCNDADKKA---DNQEKTIINIQA----KCEDTVEK
LQAEC-RK----LEENNKELMKEC-TLLKERQCQYEKEKEEGEV--VMRQLQREVGDT--
--LNKQ------SLSEAMLEISSQCHHNLEDETRDSKKKLDQLRSQ-VCMKLSMSTVTL-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

------------------MRKLFSFGRRLG------------------------------
--------------------------------------------------------QALL
NS----------------------------------------------MD-QEYAGRGYH
IGDWELRK-----IHM---------------VAIKGDA----------------------
AE---VERCLTRRF-RD--LD---------------------------------------
------------------------------------------------------------
-AVHCQEEACAIIFL-EHGANPNIKDIY----SN--TALYYAV-YNKGTSLAEKLLSHHA
NIKALNKE-G---NTPLL------FAINSGRQHVVE-FLLKNQAN--------IHSV---
-DNFRR-------TA-LMLAVQ--HSSS--SIISL-------------------------
--LL-QQN-ISI--------FSQD------MFG-QMAED---YA-VC---CDL---RR--
--YVLILKDRLI------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------L--------------
----------N-------------------------------------------------
------------------------------------------------------------
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-----------------------------

MVA-----EVSSIPAASAVKKPFGLRSKMGKWC---------------------------
----------CHCFPCCRGSGKSNVGTSGDQDDSAMKTLRSKMAKWCRHCFPCCRGSGES
NVGPSGDQDDSAMKTHRSKMAKW-CCHCFPRCKGNGESNVEAWEDYDD---SAFMEPRYH
VRGEDLDK-----LHR---------------AAWWGKV----------------------
PR---KDLIVMLRD-TD--VN-KTDKQK------------------RTAL----------
----------HLAS--ANGNSEIVKLLLDRRCQLNV--LDNKKRTALIK-----------
-AVQCQEDECALMLL-EHGTDPNIPDEY----GN--TALHYAI-YNEDKLMAKALLLYGA
DIESKNKH-G---LTPLL------LGVRGQKHQVVK-FLIKKKAN--------LSAR---
-DRCGR-------NA-LILAVH--CGS-A-SIVSL-------------------------
--LL-EQN-IDI--------SSKD------LSG-QTARE---YA-VS---SHH---NW--
--FI--LTEY----------MD--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------FSTEQ-----------
---------DLKLTSEE------------------ESQ------------RLK-------
--------------------------------GSENS-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------QPE--------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------EMSQEPEINK-----------
---DCDREAE--------------------------------------------------
---------EDMKKHG--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----SNN------------------------------MGLP------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------ENLTNDAAAGNGD-------------
--DGLIP----QSKSRTP---ESQ-----QFPD-TENEE--Y-HS---------------
------------------------------------------------------------
------------DEQNDTQKQVSEEQNAGISQEEIL-----TG---K--QEQMEVAE---
-KKMNSEVSLT-----NKKEKD---LLHE------NRMLQEELAMLRLEVDKIKEQSQLR
EKKLLEEIESVKAKNDKLLKAVKLNEEALA--------KISI------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

----------------MKKILVHG----VK------------------------------
---------------------------------------------------------EKT
PMGF--------------CDVPRKNLLDFLR--------------DM-----KSISVPNE
PRYKPLRK-----IHQ---------------AASEGDT----------------------
ER---LQKMISLG-KHS--VH-DRDFK------------------QRTAL----------
----------HFAC--AYGHVEVVSVLLRNNCDIDA--ADRNSITPLMK-----------
-AVQNWTYECVCTLL-KHGADPNRMDKN----GN--TSLHYAV-SEDNQTLAKCLLKYSA
NLEQKNKD-G---FTPLL------LALKENKIEMAK-FLVKKGAN--------IHVF---
-DEMKR-------NT-LLYAIR--WDSK--DMVNL-------------------------
--LL-DEG-IDF--------FFKD------VFG-WTALR---YA-IE---GTS---K---
-GSREILMNYDEKLRRKNKNGIPEYKKFEDN---------------------SLDKHPN-
DPTSGSNLPKSSENACDFDYELDI------SKCALTTCPSNICGAGDQEDKSEAKATVD-
------------------------------------------------------------
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-------------------------GSR--------------------------------
--------------------------------------------------------RGQT
AQG---------------------------------------------SIDHVYTGSGYR
IRDSELQK-----IHR---------------AAVKGDA----------------------
AE---VERCLVR-RSGD--LD-ALDKQ------------------HRTAL----------
----------YLAC--ASGHVNMVTLLVNRKCQIGI--CDKENRMPLIQ-----------
-AVHCQEEACAVILV-EHGANPNLKDIY----GN--TALHYAV-YSESTSLAEKLLFH--
-----------------------------------E-FLLKNKAS--------THAI---
-DRLRLP------H----ACCA--YDSP--GIANI-------------------------
--LL-KQN-INV--------FTQD------MCG-QDAED---YA-IS---HHL---TK--
--N--QLAHFHCVFLL-S----S----IFHELCVD-------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------SLPA-
--------SHDKDLSV--A------------T--------K-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------QYVP-------------E
K-------------VSEPLPGP--------------------------------------
------------------------------------------------------------
-----------------------------------SHEKGNR------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------IVNGKGE-----
------------------------------------GPPAKH-----PSL--------KM
-EDPAVKG-----------------------------AVQ--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------RKNVQTLRAEQ-ALREASEEEQERL
--------------ERSEKK-QPQ---------------VKEG--NNT---N---K----
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--------------------------------------------------KNEEKINVNM
LY-KKNTEE----LERKEKQ------------------YKKEVEAKQ-LELTVQSLEMKP
KTARNTPN-Q--------------------------------------------------
------------DFHNHEEMKD---LMDE------NCILKTDIAILRQEICTMKNDNLEK
ENKYLKELK-----------FMKLNEEMIT--------KTAFQYQQELNDL-K------A
ENVRLNSK-----------------------------------LLKEKESK---------
--ERLEADIESYQSRLAAAVSKH--NESVKTERNLK----LALERTQDISE--QVKISSD
ISKVKDENEFLT--------------------------E-QLFKMQIKFNT--LKDKFRK
TR-DTLRKKSLA-LET--VQNDL--SQTQQQIKE-----MKEMYQN-AEAEV------SK
STGKWNCVEERICQLQRENLWLVQQLDDVHQKE---DHEE-IVINIQR----GFI-----
---ES-GKKDLLLEEKNKKRMNEY-NYLKESLFQYEKEKTERVV--STKEDKYFQTSR--
--KKI-------------------------------------------------------
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-----------------------------

MVV-----EVDSMPAASSVKKPFGLRSKMGKWC---------------------------
----------CRCFPCYRESGKSNVGTSGDHDDSAMKTLRSKMGKWCHHCFPCCRGSGKS
NVGASGDHDDSAMKTLRNKMGKW-CCHCFPCCRGSGKSKVGAWGDYDD---SAFMEPRYH
VRGEDLDK-----LHR---------------AAWWGKV----------------------
PR---KDLIVMLRD-TD--VN-KKDKQK------------------RTAL----------
----------HLAS--ANGNSEVVKLLLDRRCQLNV--LDNKKRTALIK-----------
-AVQCQEDECALMLL-EHGTDPNIPDEY----GN--TTLHYAI-YNEDKLMAKALLLYGA
DIESKNKH-G---LTPLL------LGVHEQKQQVVK-FLIKKKAN--------LNAL---
-DRYGR-------TA-LILAVC--CGS-A-SIVSL-------------------------
--LL-EQN-IDV--------SSQD------LSG-QTARE---YA-VS---SHH---HV--
--ICQLLSDYKEKQMLKISSEN--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------SNPEQ-----------
---------ELKLTSEE------------------ESQ------------RFK-------
--------------------------------GSENS-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------QPE--------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------KMSQELEINK-----------
---DGDREVE--------------------------------------------------
---------EEMKKHE--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----SNN------------------------------VGLL------------------
------------------------------------------------------------
-----------------------------------------E-------NL---------
--------------------------------------------------TNG-------
------------------------------------VTA---------------------
---G---------NG---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------D-NGLI---------------------------P----
----Q-------------------------------------------------RKSRTP
----------------------------------------ENQ-----------------
--QFPDNE------------------------------------------------SE--
------------------E-----------------------------------------
----------------------------------------------------YH------
-RICELLSDYK-------------------------------------------------
------------------------------------------------------------
-----------------------------E------------------------------
-------KQMPKYSS---------------------------------------------
------------------------------------------------------------
-------------------------------ENSNPEQD---LKLTSEEESQRL------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------KGSEN-GQPEKRSQE------------------------
---------------------------------------------------------PEI
------------NKDGDRELENFMAIEE-M-----K--KHG--STHVG------------
-------------F-------------------PENLTNGATAGNGD-------------
--DGLIP----PRKSRTP---ESQ-----QFPD-TENEE--Y-HS---------------
------------------------------------------------------------
------------DEQNDTQKQFCEEQNTGILHDEIL-----IH---E--EKQIEVVE---
-K-MNSELSLS-----CKKEKD---VLHE------NSTLREEIAMLRLELDTMKHQSQLR
EKKYLEDIESVKKKNDNLLKALQLNELT MD--------DDTAVLVIDNGSGMCKAGFAGD
DAPRAVFP-----------------------------------SIVGRPRQQGMMGGMHQ
KESYVGKEAQSKRGI-------------LTLKYPMEHGIITNWDDMEKIWHHT-------
----------------FYNELRVAPEEHPILLT-----EAPLNPKANREKM---------
-------------------------TQIMFETFN-----TPAMYVA-IQAVP------SL
YTSGR---------------------------------TTGIVMDSGD----GVTHTVPI
YEGNALPHATLRLDLAGRELPDYLMKILTERGYRFTT-MAEREI---VRDIKEKLCYVAL
DFEQEMATAASSSSLEKSYELPDGQVITIGNERFRCPEALFQPCF----------LGMES
CGIHETTFNSIMKSDVDI-RKDLYTNTVL-SGGTT---MYPGMAHRMQKEIAA-------
-------LA----PSMMKI--------------RIIAPPKRKYSV---WVGGSILASLST
FQQMWISKQEYDE-----------------------SG-------------PS-------
------------------------------------------------------------
-------------------------------------IVHRKCF----------------
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-----------------------------

------------------------------------------------------------
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----------------------------------------------MIVSSFHSPGPGYH
IKYQDLRK-----IHR---------------AVVADDP----------------------
GKLQDVEQFLLFDL-CD--IN-ERDRK------------------NRTAL----------
----------HLAC--AIGRVDVVKYLLAWKCDVNL--RDGENRTALVK-----------
-AVQCQKEACVDILL-KKGADPNAKDFK----GN--TALHYAA-FEGNILIAQKLLFNKG
EIEAKNKD-G---LTPLL------VAVNEKKEKMVV-FLL-EEAN--------INAV---
-DYTKS-------QA-MFEAVQ--SQDE--ACVDI-------------------------
--LL-KHG-ANP--------DLKD------IKG-NTALH---YA-AL---GDN---VT--
--IAQK--LL---------LKKV-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------N--------------
----------ME--IR--N-------------------------KV--------------
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-----------------------------------------QDL----------K-----
---------------------------------------ITSEGE----------QEKL-
------------------------------------------------------------
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-----------------------------------QECENIQQQVTEKMKTC---RNKKV
EVSR--------------------------------------------------------
------------------------------N-----------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------LDADYSDS---DDNEL-IQER----------
--RSR------K------------------------------------------------
------------------------------------------PD----------------
------------------------------------------------------------
---------------------------------NPQFS----------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------R
-------------------------------------------Q----------------
-------------------KSEEY---NRLAEKTSNKENK--------------------
---------------------------------------------VKRHLYFKDDP-DDI
IWSSETTSEVDELP--YSDYKNFMLLIEQHR---ME--CK--DFVSLLKIKNA----ISA
HERLIEH---KIHY-------------------CEQLTVKFKKMKNK-------------
--ISTLQ----KELSETD---KTKVQLEHQKLE-WKQEL--HSLRLILQQEEERR--NPE
KY-EKGTEN----FKIMEEQ------------------YWTQAEVKKQLKLTLKSLEMEL
KTVRNYLN----------------------------------------------------
----------Q-SSHTHEKEKD---LWQK------NHLMKDEIARLRLEIDTIKHQNQEN
ENTYFKDSEIIKKKNEDLQKTLKLNEETLT--------K-TNWYNEELNVL-TL-----D
KNTVLNSE-----------------------------------LEKEKQRK---------
--QRLETEMELYSCRLAAALCDR--DQSQSSKRDLQ----LAFQNTVNQWCHLQENMNSH
-------IQILS--------------------------Q-QLSKAESKSSS--LETELNY
ER-EALKEKTLA-IEH--MQGVI--SQTQHRVKA-----IEHMYQD-DQHIV------EK
YVRKQQSVEDGLFQIQSQNSLHQQQLNDAHKKA---DNQEKTIINIQA----KCEDTVEK
LQAEC-RKHCIMLEENNKGLIEEY-TLLKERQCQYEKEKEEEEV--VVRKLKQELSDA--
--LNKQ------LLSEGMLEASSQHQNTLEDETRDTKKKFEQMKSQ-VCMKLSMLTVTL-
------------------------------------------------------------
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-----------------------------

------------------------------------------------------------
------------------------------------------------------------
-WPK--------------RKN----RLQHLW-------------------GDGFSCAEYK
IKPSHLQR-----IHR---------------AAVSGKL----------------------
EK---LDT-ILIT-ENC--IN-DKDKK------------------NRTAL----------
----------HLAC--ATGQYQVVELLVLNNCQLNL--LDSECRTPLIK-----------
-AIQLKQVSCATFLL-EKGADPNVMDYY----GR--TALHYAV-YNEDTAMIERLLSHGT
DIERSSKE-E---PPPLL------LAVSQGKLKMVE-FLLKKNAN--------INAL---
-DSLKR-------SA-LTLAVR--LEKR--DIVVL-------------------------
--LL-QHN-IDV--------FSLD------VYG-KTAEN---YA-AA---AEN---EI--
--ILKLISEYKEEKKSKALSINS-----NPGKISG---------------SELLLMATSD
KKDCVSNIATEIKDGPKSGTVSSQEQLASKATSDKKDCVSNIAAEIKDGPKS---GTVSS
Q---KQLALTATSDKKDPV----SNIATEIKDGSKSGTGIFTGSVCF-------------
-------------------------VLRNKRAHFCCIFLLCRHLWKP------DTVAKP-
--------VPEDESDS--DSEVNINCILCQRYFT------------------------A-
---------------------------------------DYFA-----------------
------------------------------------------------------------
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------------------------------------------------------------
----------------------------------------------SNPIQAT----RKK
-KDPVSNI-----------------------------STEIKDGSNSGTVSSVK------
------RPALRATSDKKTSVSVIAREI---------------------------------
-----------KDGDKSGTGN--------FA-------TSDKKTSVS--VI------ASE
IKNGD---KSGRGNFSVKYTSC--------------------------------------
-----------SDYFASNPIQAT---CKKKDPVSNIATE-----------------IKDG
SKSGTVSSVKQPALR------------ATSDK---KTSVSVIA----------SEIKDGD
KSGTVSSQKQWASKATRKKKDPVSNIA------TEIKDGSKYGTGNFLKGKLKEA-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------EIT---------------
-----STS---------------------------------TKR-ISTQRPRPKVTN---
-----------------DK-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------DHRMKT-----------PKTRIDKTDSVSNITTEI-KD------------
GKKSGTVSSQKQPAWKTTSNKKDSVSNIAT-------E--T----------KDVQKSGTV
-----------------------------------YSQKQ--LALKATIDKKDSVSNIAT
------------------------EIKDGQKSETGNFA----------------------
---------------------------------------IIKKKVSISNIATGITVVEK-
-------------------------------SGAEYPENLPTLKVTSEN-----------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------KD-SVL-NIATEMKDVHTPLP-
EQDLEMA------SEGEQKRFEEYEY-NQPWMKNQIH---------FRDD----------
-------------------------------------------------------L-DDI
IELSQIASEGED--SLS--SKKVILLIDQHG---MQ--CKD--CVHLLKIKNA----IYL
RERSI------ENH-------------------CERLTGKIQKMKNK-------------
--ISILQ----KRLSEEK---EIISQLEHEKPE-WEKIL--CSLRYAIPQEKEKGRNSEK
LH-EEVREK----II-IEEQ------------------YAIDAKEIKQLKLAITSLEVEL
ETVENDS-----------------------------------------------------
---------NQ-ISDSHGK-ED---LLPK------NHLMQDEIARLRLEIETIKNQNL--
EKKYLKDIEIIKGRNEDLQKALKWNGETLT--------KMIARSSGRLTAL-T------D
ENTMLRSK-----------------------------------LEQEKESN---------
--RRLETEIESYRCRLNAVLRDH--DQSQSSERDQE----LAFQRTVDKWCHLQENLNSH
-------VLILS--------------------------Q-QLSKAESKSSG--LETELCY
TR-EALKEKTLV-FEC--MQRDL--NQTQCQMKD-----IEKMYKN-GQDKV------EK
CIEKQ----ERLCQLHRQSMLLQQQLNDAHNKA---DNQEKILINIQA----KCDARVQN
VQAEC-RKCSILLEEENKRLISEV-NHLKEKQCQYERERAEREV--LVRQLQQKRDDA--
--LHKE------STSKTLVDASLCRSIHLESELEDSKKKAGQMRSQ-FQGIQDQLTATLR
R-----------------------------------TEKTQGHIQKLEMENSVIRNIIKN
QDDQIEQLQ----KIMQNS-----------------------------------------
------------------------------TLVS--------------------------
------------------------------------------------------------
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-----------------------------

----------------MKKILVHG----VK------------------------------
---------------------------------------------------------EKT
PMGF--------------CDVPRKNLLDFLR--------------DM-----KTISVPNE
PRYKPLRK-----IHQ---------------AASDGDT----------------------
ER---LQRMISLG-KHS--VH-DRDFK------------------ERTAL----------
----------HFAC--ACGQVEVVSILLRNNCDVDA--ADMNFITPLMK-----------
-AVQNWTYECVCILL-KHGADPNRKDKN----GN--TPLHYAV-SEDNQTLAKCLLKYSA
NMEQKNKD-G---FTPLL------LALKENKIEMAK-FLVKMGAN--------IHVF---
-DDMRR-------NT-LLYAIR--WDSK--DMVNL-------------------------
--LL-DEG-IDF--------FFRD------VFG-WTALR---YA-IE---GTS---K---
-GSREILMNYDEMLRRKNKDGIQEYKFFEDK---------------------SLDKRPN-
DPTSGSTFSKSNENACKFDDEPDI------SKYALATCPNNIHGAGEEGDKSETKEAADV
Q------VWTNPTL----------KSSTKGKV-----PNLNEVGTLTESHHFIK------
------ESDLEI-----------------------------ESLEESFSYANEDKQ--SV
--------SDGGHFSG--TTPK-----------WCQN---DT--NRKTTVQD--CMYP--
-----------NLKSST------------------EGKIPTH-SKAGKMAESP-------
-------------HFIIESDLEIESLEETVSCDSE-----DK------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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----------QLLV----------------------------------------------
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-----------------------------

Query Results

"ENSGT00560000076605_0"

ENSGT00560000076605_0