Query Results 

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-----MATVVVEATEPEPSGSIANPAASTSPSLSHRFLDSKFYLLVVVGETVTEEHLRRA
IGNIE-LGIRSWDTNLIECNLDQELKLFVSRHSARFSPEVP-----------GQKILHHR
SDVLETVVLINPSDEAVSTEVRLMITDAARHKLLVLTGQCFENTGELILQSGSFSFQNFI
EIFTDQEIGELLSTTHPANKASLTLFCPEEGDWKNSNLDRHNLQDFINIKLNSASILPEM
EGLSEFTEYLSESVEVPSPFDILEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFNML
INGGSERKSCFWKLIRHLDRVDSILLTHIGDDNLPGINSMLQRKIAELEEERSQGSTSNS
DWMKNLISPDLGVVFLNVPENLKNPEPNIKMKRSIEEACFTLQYLNKLSMKPEPLFRSVG
NTIEPVILFQKMGVGKLEMYVLNPVKTSKEMQYFMQQW---T-GTN-KDKAE-LILPN-G
QEVD-IPISYL-TSVSS-LIVWHPANPAEKIIRVLFPGNSTQYNILEGLEKLKHLDFLKQ
PLATQKDLTGQVPTPT-AKQVKLKQRADSRESLKPAAKPLPS-KSVRKESKEEAPEVTKA
SQ-VEKTPKVESKEKVIVKKDK------PVKTEPKPSVTEKELPSR--EEQSPVKAEVAE
K---PATESKPKVTKEKVVKKEIKAKPEDKKEE--KEKPKKEVAKKEDKTPLKKDEKPKK
EEVKKEVKKEIKKEEKKELKKEVKKETPLKEAKKEVKKEEKKEVKKEEKEPKKEIKKISK
DIKK-STPLSETKKPAALKPKVAKKEESTKKEPA-AASKLKDKGKVKVVKKEGKTTEAAA
TAVG-TAATAAAAVAAAGIAAAGGPAKELEAERSLMSSPEDLTKDFEELKAEEIDVAKDI
KPQLELIEDEEKLKETEPVEAYVIQKETEVSKGSAESPDEGITTTEGEGECEQTPEELEP
VEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEDNVSGSASKHSPT--
--------EDDECAKAEADVHI----K-EKRESVTSGDDRAEEDMDEALEKGEAEQSEEE
G--EE-EDKAEDAREEDYEPEK-AEAEDYVMAVVDKAAE-AGVAEEQY-GFLSTPTKQPG
AQSPGREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPM
DEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYSQEYSKPA----VASFNGLSEGS
KTDATDGKDYNASASTISPPSSMEEDKFSKSALRDAYCSDEKEVKASAVLDI----KD--
ISDERLSPSKSPSLSPSPPSPIEKTPLGERSVNFSLTPNEIKVSAEAEATS-VSPGVTQA
VVEEHCASPEEKTLEVASPSQSVTGSAGHTPYYQSPTDEKSSHLPTEATEKPQAVPAGFE
FSE-AKDEHERASISPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYDDFLTADSKALGR
CTESPFEGKDGKQGFPDKESPVSDVTSTGLYQDKQEGK-STGFIPIKEDFGPEKKTNDVE
IMSSQSALALDERKLGGDVSPTQIDVSQFGSFKEDTKMSISEGTVSDKSATPVDEGVAED
TYSHMEGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTF
QETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQDHRS-EQSSMSIEFGQESPEHSLAM
DFSRQSPDHPTAGASVLHITENGPTEVDYSPSDIQDSSLSHKIPPMEDP-SYTQDNDLSE
LISVSQVEASPSTSSAHTPSQIASPLQEDTLSDVVPPRDMSLYASLTSEKVQSLEGEKLS
PKSDISPLTPRESSPLYSPGFSDSTSAATENAAGR-QTS-SPPLDAASAEPYGFRASMLF
DTMQHHLALNRDLTTSSVEK---DSGGKTPGDFSYAYQKPEKTTRSPDE-EDYDYESYGK
S

PF00414 // ENSGT00550000074593_0_Domain_5 (2102, 2117)

TRAPDVGGYYYEKTE

ENSGT00550000074593_0_Linker_5_6 (2117, 2120)

RTM

PF00414 // ENSGT00550000074593_0_Domain_6 (2120, 2134)

KSPCDSGYSYETIEKTIKPPEDGGYACEITEK

PF00414 // ENSGT00550000074593_0_Domain_9 (2152, 2168)

TTRTPEEGG
YSYEISE

ENSGT00550000074593_0_Linker_9_10 (2168, 2169)

K

PF00414 // ENSGT00550000074593_0_Domain_10 (2169, 2185)

TTRTPEVSGYTYEKTERS-RRLLDDISNGYDDSEDGGHTLGDCSYSYETTEK
ITS-FPESESYSYETSTK

PF00414 // ENSGT00550000074593_0_Domain_14 (2239, 2256)

TTRSPDTE-TYCYETME

ENSGT00550000074593_0_Linker_14_15 (2256, 2257)

K

PF00414 // ENSGT00550000074593_0_Domain_15 (2257, 2290)

ITKTPQASTYSYETS---------
--------DRC---YTTE--------------KKSPSEARQDVDLCLVSSCEYKHPKTEL
SPSFINPNPLEWFASEESTEDSEKPLTQAGGAPPPSGGKQQGRQCDETPPTSVSESAPSQ
TDSDVPPETEECPSITADANIDSEDESETIPTDKTVTYKHMDPPPAPMQDRSPSPRHPDV
SMVDPEALALEQNLGKALKKDLKEKAKTKKPGTKTKSSSPVKKGDGKSKPLAASPKPGAL
KESSDKVSRVASPKKKESVEKATKTT-TTPEVK--AARGEEKDKETKNAANASASKSAKT
ATA----GPGTTKTAKSSTVPPGLPVYLDLCYIPNHSNSKNVDVEFFKRVRSSYYVVSGN
DPAAEEPSRAVLDALLEGKAQWGSNMQVTLIPTHDSEVMREWYQETHEKQQDLNIMVLAS
SSTVVMQDESFPACKIEL

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-----MATVVVEAAEPELSGSTANPAASTSPSLSHRFLDSKFYLLVVVGEIVTEEHLRRA
IGNIE-LGIRSWDTNLIECNLDQELKLFVSRHSARFSPEVP-----------GQKILHHR
SDVLETVVLINSSDEAVSTEVRLMITDAARHKLLLLTGQCFENTGELILQSGSFSFQNFI
EIFTDQEIGELLSTTHPANKASLTLFCPEEGDWKNSNLDRHNLQDFINIKLNSASILPEM
EGLSEFTEYLSESVEVPSPFDILEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFNML
INGGSERKSCFWKLIRHLDRVDSILLTHIGDDNLPGINSMLQRKIAELEEEQSQGSTTNS
DWMKNLISPDLGVVFLNVPENLKNPDPNIKMKRSIEEACFTLQYLNKLSMKPEPLFRSVG
NIIDPVILFQKMGVGKLEMYVLNPLKSSKEMQYFMQQW---T-GTN-KDKAE-LILPN-G
QEID-IPVSYL-TSVSS-LIVWHPANPAEKIIRVLFPGNSTQYNILEGLEKLKHLDFLKQ
PLATQKDLTGQVATPA-VKQVKLKQRADSRESLKPATKTLAS-KSVRKESKEETPEVTKA
NH-VEKSPKVESKEKVTVKKDK------PVKTETKPPVTEKEVPSK--EEQPPVKAEVAE
K---QATDVKPKVTKEKTVKKETKAKPEEKKEE--KEKTKKEVAKKEDKTPIKKEEKPKK
EETKKEVKKEIKKEEKKESKKEVKKETPLKEAKKEVKKEEKKEIKKEEKEPKKEIKKLPK
DAKKSSTPLSEAKKPAALKPKVPKKEESIKKDSV-AAGKPKEKGKIKVVKKEGKTAEAAA
-AAI-GTVAAAAAVATAAGIATAGPTKEL

PF00183 // ENSGT00550000074593_0_Domain_1 (990, 1015)

EAERSLMSSPEDLTKDFEELKAEEV

ENSGT00550000074593_0_Linker_1_2 (1015, 1490)

DVAKDI
KPQLELIEDAEKLKETEPVEAYVIQKETEVIKGPAESPDEGITTTEGEGECEQTPEELEP
VEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEDDGEEAACVSTSKHSPV--
-------EE-DESAKAEADVHI----K-EKRESVASGDDRAEEDMDEAVEKGEAEQSEEE
G--D-EEDKAEDAREEEYEPEK-AEAEDYVMAVVDKAAE-AGGAEDQY-GFLTTSAKQLE
AQSPAREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPM
DEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYSQEYSKPA----VTSLNGLSEGS
KTDATDGKDYNASASTISPPSSMEEDKFSKSVLRDAYCFEGKDLKAGAALEIKDTVSA--
VSDEKLSSSKSPSLSPSPPSPIEKTPLGERSVNFSLTPNEIKVSAKAET

PF02818 // ENSGT00550000074593_0_Domain_2 (1490, 1516)

AP-VSPEVTRE
VVEEHCASPEDKTLE

ENSGT00550000074593_0_Linker_2_3 (1516, 2066)

VVSPSQSVTGSAGHTPYYQSPTDEKSSHLPTEVIEKPPAVPVSFE
FSD-AKDENERASISPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYESFLSADDKAPGR
RAESPFEGKNGKQGFSDQISPVSDMTSTGLFQDKLEGK-STDFIPIKEDFGQEKKTDDIE
AMSSQSGLALDERKLGGDVSPTQIDVSQFGSFKEDTKMSISEGTVSDKSATPVDEGVAED
TYSHMEGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTF
QETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQDHRS-EQSSMSIEFGQESPEHSLAM
DFSRQSPDHPTAGAGMLHITENGPTEVDYSPSDMQDSSLSHKIPPMEEP-SYTQDNDLSE
LISVSQVEASPSTSSAHTPSQIASPLQEDTLSDVAPPRDMSLYASLTSEKVQSLEGEKLS
PKSDISPLTPRESSPLYSPSFSDSTSAIKENIAACHTSS-SPPIEAASAEPYGFRASMLF
DTMQHHLALNRDLTTSVVEK---DI

PF00414 // ENSGT00550000074593_0_Domain_3 (2066, 2082)

GGKTPGDFSYAYQKSE

ENSGT00550000074593_0_Linker_3_4 (2082, 2084)

K-

PF00414 // ENSGT00550000074593_0_Domain_4 (2084, 2100)

TRSPDE-EGYDYESYE

ENSGT00550000074593_0_Linker_4_5 (2100, 2101)

K

PF00414 // ENSGT00550000074593_0_Domain_5 (2101, 2117)

TTRTPDVSGYYYEKTE

ENSGT00550000074593_0_Linker_5_6 (2117, 2118)

R

PF00414 // ENSGT00550000074593_0_Domain_6 (2118, 2134)

TTQSLCDSGYSHETTE

ENSGT00550000074593_0_Linker_6_7 (2134, 2135)

K

PF00414 // ENSGT00550000074593_0_Domain_7 (2135, 2151)

TTKTPDDDSYAYEITE

ENSGT00550000074593_0_Linker_7_9 (2151, 2152)

K

PF00414 // ENSGT00550000074593_0_Domain_9 (2152, 2168)

TTRSPEESG
YSYEISE

ENSGT00550000074593_0_Linker_9_10 (2168, 2169)

K

PF00414 // ENSGT00550000074593_0_Domain_10 (2169, 2185)

TIRTPEVSGYGYEKTERS-RRLLDDISNGYDDSED

PF00414 // ENSGT00550000074593_0_Domain_12 (2204, 2220)

GGHTLGDSSYSYETTEK
IAS-FPESESYSCETSTK

PF00414 // ENSGT00550000074593_0_Domain_14 (2239, 2256)

TTRTPDTS-TYCYEAAE

ENSGT00550000074593_0_Linker_14_15 (2256, 2257)

K

PF00414 // ENSGT00550000074593_0_Domain_15 (2257, 2290)

ISRTPQGSTYSYETS---------
--------DQC---YAAE--------------KKSPSEARQDVDLCLVSSCEYKHPKTEL
SPSFINPNPLEWFASEEPTEESEKPLTQSGGAPPPPGGKPQGRQCDETPPTSVSESAPSQ
TDSDVPPETEECPSITADANIDSEDESETIPTDKTVTYKHMDPPPAPMQDRSPSPRHPDV
SMMDPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKSDGKSKPSAASPKPGGL
KESSDKVSRVASPKKKESVEKATKPT-TTPEVK--AARGEEKDKETKNAANASTSKSVKT
ATA----GPGTTKTAKLSAVPPGPPVYLDLCYIPNHSNSKNVDVEFFKRVRSSYYVVSGN
DPAAEEPSRAVLDALLEGKAQWGSNMQVTLIPTHDSEVMREWYQETHEKQQDLNIMVLAS
SSTVVMQDESFPACKIEL

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--------IRSWDTNLIECNLDQELKLFVSRHSARFSPEVP-----------GQKILHHR
SDVLETVVLINPSDEAVSTEVRLMITDAARHKLLVLTGQCFENTGELILQSGSFSFQNFI
EIFTDQEIGELLSTTHPANKASLTLFCPEEGDWKNSNLDRHNLQDFINIKLNSASILPEM
EGLSEFTEYLSESVEVPSPFDILEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFNML
INGGSERKSCFWKLIRHLDRVDSILLTHIGDDNLPGINSMLQRKIAELEEEQSQGSTTNS
DWMKNLISPDLGVVFLNVPENLKNPEPNIKMKRSIEEACFTLQYLNKLSMKPEPLFRSVG
NTIDPVILFQKMGVGKLEMYVLNPVKSSKEMQYFMQQW---T-GTN-KDKAE-FILPN-G
QEVD-LPISYL-TSVSS-LIVWHPANPAEKIIRVLFPGNSTQYNILEGLEKLKHLDFLKQ
PLATQKDLTGQAPTGA-SKQVKLKQRADSRESLKPAAKPLPS-KTVRKESKEETPEVTKA
NH-AEKPPKVESKEKVTVKKDK------PVKTEPKPPAAEKDVPGK--EEPSPVKAEAAE
K---QATDVKPKATKEKTVKKDTKVKPEEKKEE--KEKPKKEVAKKEDKTPVKREEKPKK
EEVKKEVKREVKKEEKKEPKKEAKKETPLKEAKKDVKREERKEIRKEEKEPKKEIKKLPK
DTKKSSAPLAEAKKPAALKPKVPKKEESVKKDSA-APGKPKEKGKIKVVKKESKTAEAAT
AAA--------GAAVAAARVAATGPAKDLEAERSLMSSPEDLTKDFEELKAEEVDVTRDI
KPQLELLEDEARWKETEPVEAYVTQKETEVVRGPAESPDEGITTTEGEGECEQTPEDLEP
AGKQGVDDTERFEDEGAGFEESSETGDYEEKAETEEAEEPEEDAEESVCARASKHSLL--
-------ED-EESTKAEADVHL----Q-AKRESVASGDDRAEEDMDEATAKGEAEPSEEE
A--E-EEDKAEDARE-DDESEN-IEAEDYVMAVVDKAAE-AGGAEDQY-GFLTAAARPPG
AQAPGREPASSIHDETLPGGSESEATASDEDNREDQPEEFTATSGYTQSTIEISSEPTPM
DEMSTPRDVLSDETNNEETESPSQEFMHVTKYESPPYTQEYPRPAA----ASLNGFSEGS
KTDATEGKDYNASASTISPPSSMEEDRFSRSALRDAYCSDVR---ASARLEIKDTVSA--
VSGDTLSPSKSPSLSPSPPSPIEKTPLGERSVNFSLTPNEIKVSAEAEAVS-VSPEVTQE
VVEEHCASPEDKTLEVVSPSQSVTGSAGHTPYYQSPTDEKSSHLPTEVSGKPPAVPVTFE
FSE-AKDENERASISPMDEPVPDSESPMEKVLSPLRSPPLIGSEPAYDSFLRADGKASGR
YTESPFGEKNGKQGSPDQVSPVSETTATGHYHDRQEGK-STDFIPIKEDLGQEKKTDDVE
AIRSQPALALDERKLGGDVSPTQIDVSQFGSLKEDTKMSISEGTVSDKSATPVDEGVAED
TYSHMEGVASVSTASVATSSFPEPTTDDASPSLHAEVGSPHSTEVDDSLSVSVVQTPTAF
QETEMSPSKEECPRPMSISPPDFSPKTATSRTPVQDHRS-EQSSMSIEFGQESPEHSLAM
DFSRQSPDHPTMGAGVLHITENGPTEVDYSPSDMQDSSLSHKIPPMEEP-SYTQDNDLSE
LISVSQVEASPSTSSAHTPSQIASPLQEDTLSDAAPPRDMSLYASLTSEKVKSLEGEKLS
PKSDISPLTPRESSPLYSPSFSDSTSAAKENTVARHTSS-SPPVDAASAEPYGFRASMLF
DTMQHHLALNRDLTTSGMER---DNGGKTPGDFSYAYPKSEKTTRLPDE-EDCDYGSYRK

PF00414 // ENSGT00550000074593_0_Domain_5 (2101, 2117)

TTRTPDMVGYYYEKTE

ENSGT00550000074593_0_Linker_5_6 (2117, 2118)

R

PF00414 // ENSGT00550000074593_0_Domain_6 (2118, 2134)

TTKSPGDSDYSYETIE

ENSGT00550000074593_0_Linker_6_8 (2134, 2135)

K

PF00414 // ENSGT00550000074593_0_Domain_8 (2135, 2168)

TTKTPE-----------------DGG
YAYEITE

ENSGT00550000074593_0_Linker_8_10 (2168, 2169)

K

PF00414 // ENSGT00550000074593_0_Domain_10 (2169, 2185)

TTRTPEVSGYSYEKTERS-RRLLDDISNGYDDSEDG

PF00414 // ENSGT00550000074593_0_Domain_12 (2205, 2220)

GHPLGDSSYSYETTEK
IAS-FPESESYSYGTSIT

PF00414 // ENSGT00550000074593_0_Domain_14 (2239, 2256)

TARTPDAS-TYCYETTE

ENSGT00550000074593_0_Linker_14_15 (2256, 2257)

K

PF00414 // ENSGT00550000074593_0_Domain_15 (2257, 2290)

ITRTPQASTYAYETS---------
--------DRC---YTAE--------------KKSPSEARQDVDLCLVSSCEYKHPKTEL
SPSFINPNPLEWFASEEAPEESERPLTQSGGAPPPPGGKQQGRQCDETPPTSVSESAPSQ
TDSDVPPETEECPSITADANIDSEDESETIPTDKTVTYKHMDPPPAPMQDRSPSPRHPDV
SMVDPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKSDGKSKPLAASPKPGTL
KESSDKVSRVASPKKKESVEKATKTT-ATPEVK--AARGEEKDKETKNAANASASKSVKT
ATA----GPGTTKTAKSSAVPPGLPVYLDLCYIPNHSNSKNVDVEFFKRVRSSYYVVSGN
DPAAEEPSRAVLDALLEGKSQWGSNMQVTLIPTHDSEVMREWYQETHEKQQDLNIMVLAS
SSTVVMQDESFPACKIEL

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-----MATVVVEAAEPEPSGSIANPAASTSPSLSHRFLDSKFYLLVVVGEIVTEEHLRRA
IGNIE-LGIRSWDTNLIECNLDQELKLFVSRHSARFSPEVP-----------GQKILHHR
SDVLETVVLINPSDEAVSTEVRLMITDAARHKLLVLTGQCFENTGELILQSGSFSFQNFI
EIFTDQEIGELLSTTHPANKASLTLFCPEEGDWKNSNLDRHNLQDFINIKLNSASILPEM
EGLSEFTEYLSESVEVPSPFDILEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFNML
INGGSERKSCFWKLIRHLDRVDSILLTHIGDDNLPGINSMLQRKIAELEEEQSQGSTTNS
DWMKNLISPDLGVVFLNVPENLKNPEPNIKMKRSIEEACFTLQYLNKLSMKPEPLFRSVG
NTIDPVILFQKMGVGKLEMYVLNPVKNSKEMLYFMQQW---T-GTN-KDKAE-LILPN-G
QEID-IPISYL-TSVSS-LIVWHPANPAEKIIRVLFPGNSTQYNILEGLEKLKHLDFLKQ
PLATQKDLTGQVAAPA-VKQVKLKQRADSRESLKPAAKPLPS-KSVRKESKEETPDVTKA
NH-VEKPPKVESKEKVTVKKDK------PVKTETKPVVTEKEVPSK--EELPPVKAEVAE
K---QATDVKPKVSKEKTVKKETKAKSEEKKEE--KEKPKKEVAKKEDKTPIKKEEKPKK
EEVKKEVKKEIKKEEKKEPKKEVKKETPLKEAKKEVKKEEKKEIKKEEKEPKKEIKKLPK
DAKKPSTPLSEAKKPAALKPKVPKKEEPVKKDSV-AAGKPKEKGKIKVVKKEGKTPEAAA
A-AI-GSVAAVAAVAAAAGMASAGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVAKDI
KPQLELIEDEEKLKETEPVEAYVLQKETEVIKGPAESPDEGITTTEGEGECEQTPEELEP
VEKQGVDDIEKFEDEGTGFEESSETGDYEEKAETEEAEEPDEDVEETVCVSTSKHSLM--
-------EE-EESAKAEADVHI----K-EKRESLASGDDRAEEDMDEVVEKGEAEQSEEE
G--D-EEDRAEDAREEEYEPEK-AEAEDYVMAVVDKAAE-ASGVEDQY-GFLTTSIKQPG
AQSPAREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPM
DEMSTPRDVMSDEINNEETESPSQEFVNITKYESSLYSQEYCKPA----VTSLNGLSEGS
KTDATDGKDYNASASTISPPSSMEEDKFSRSVLRDAYYTEEKDMKASATLVIKDTISA--
VSDEKLSPPKSPSLSPSPPSPIEKTPLGERSVNFSLTPNEIQVSAEAEAVP-VSPEVTQE
VVEEHCASPEDKTLEVVSPSQSVTGSAGHTPYYQSPTEEKSSHLPTEVTEKPPTVPVSFE
FSD-AKDENERASISPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYESFLSADDKTSGR
GTESPFEGKDGKQGFPHEISPISDMTSTGLSQDKPEEK-STDFIPIKEDFGQEKKPDDVE
AMSSQSGLALDERKLGGDVSPTQIDVSQFGSFKEDTKMSISEGTVSDKSATPVDEGVAED
TYSHMEGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTF
QETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQDHRS-EQSSMSIEFGQESPEHSLAM
DFSRQSPDHPTVGASMLHITENGPTEVDYSP-DMQDSSLSHKIPPMEEP-SYTQDNDLSE
LISVSQVEASPSTSSAHTPSQIASPLQEDTLSDVVPPRDISLYASLTSEKVQSLEGEKLS
PKSDISPLTPRESSPLYSPSFSDSTSAVKETIAACPTAS-PPPTDAASAEPYGFRASMLF
DTVQHQLALNRDLTTSGMEK---DIGGKTPGDFSYAYQKPEKTTRSPDE-EGYEYESYEK

PF00414 // ENSGT00550000074593_0_Domain_5 (2101, 2116)

TTRTPDVSGYYYEKT

ENSGT00550000074593_0_Linker_5_6 (2116, 2118)

DS

PF00414 // ENSGT00550000074593_0_Domain_6 (2118, 2134)

TTKSPCDSSYSYETIEKTAKTPEDGGYAYEVTEETTRTPEEGE
YSYEASEKTM

PF00414 // ENSGT00550000074593_0_Domain_10 (2171, 2185)

RTPEVSGYSYEKTERSSRRLLDDISNGYDDSEDG

PF00414 // ENSGT00550000074593_0_Domain_12 (2205, 2220)

GHTLGDSSYSYETTEK
IAS-FPESESYSYETSTATTRAPDTS-TYDYEAVEK

PF00414 // ENSGT00550000074593_0_Domain_15 (2257, 2289)

ITRTPQASTYSYETS---------
--------EQC---YTVE--------------KKSPSEARQDVDLCLVSSCEYKHPKTEL
SPSFINPNPLEWFASEEPTEEAEKPLTQSGGAPPPPGGKPQGRQCDETPPTSVSESAPSQ
TDSDVPPETEECPSITADANIDSEDESETIPTDKTVTYKHMDPPPAPMQDRSPSPRHPDV
SMMDPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKGDGKSKPSAASPKPGGL
KESSDKVSRVASPKKKESVEKATKTT-TTPEVK--AARGEEKDKDTKNAANASTSKSVKT
ATA----GPGNTKPSKPSAVPPGPPVYLDLCYIPNHSNSKNVDVEFFKRVRSSYYVVSGN
DPAAEEPSRAVLDALLEGKAQWGSNMQVTLIPTHDSEVMREWYQETHEKQQDLNIMVLAS
SSTVVMQDESFPACKIEL

------------------------------------------------------------
------------------------------------------------------------
-----MATVVVEA-ESEPSCSIPNPA-STSPSLSHRFLDSKFYLLVVIGEIVTEEHLRRA
IGNIE-QGIRSWDTNLIECNLDQELKLFVSRHSARFSPDVR-----------GQKILHHR
SDVLETVVLINPSDEAVSTEVRLMITDAARHKLLVLTGQCFENTGELILQSGSFSFQNFI
EIFTDQEIGELLSTTHPANKASLTLFCPEEGDWKNSNLDRHNLQDFINIKLNSASILPEM
EGLSEFTEYLSESVEVPSPFDILEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFNML
INGGSERKSCFWKLIRHLDRVDSILLTHIGDDNLPGINSMLQRKIAELEEEQSQGSTTNS
DWMKNLISPDLGVVFLNIPENLKTPDPNIKMKRSIEEACFTLQYLNKLSMKPEPLSRNVG
NTIDPVILFQKMGVGKLEMYVLNPVKNSKEMQYFMNQW---T-GTN-KDKAE-LILPN-G
QEVD-IPVSYL-TSVSS-LIVWHPANPAEKIIRVLFPGNSPQYNILEGLEKLKHLDFLKQ
PMVTQKDLSGQVASPA-VKQVKLKQRTDSRESLKPVAKTLSS-KPVRKESKEETPETAKI
NH-VEKASKIESKEKVIVKKEK------PIKTEVKPSAPEKEVSNK--EEHSTVKAEVAE
K---QATDVKPKVSKDKIVKKEVKAKSEDKKEE--KEKPKKEVSKKEEKIPLKKEEKPKK
EDIKKEVK----KEEKKELKKEVKKETPLKEIKKEVKKEDKKEIKKEEKEIKKDIKKLPK
DTKKTS-TLSEAKKP-ILKPKVQKKEEPIKKEAA-AAGKLKEKGKIKVVKKESKVSESAA
A-AI-GTAATAVAAVAAAGISTEGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVLKET
KPQLALIEDEKKLPETEHVDAYDIQKETEVLKRPAESPDEGITTTEVEGECEQTPEELEP
TEKHREDDNEKFEDEGTGFEESSEAGDYEEKAETEEAEEPDYEGEENVPLSSAKRGVEEE
ARVLDEEEEAEEDRKMEADARG----K-EKRESLAGGDERAEEDMDEIIEKAEAEETEEE
LD---EEEKTEDARDEDYEMEKHLAEEDYVMAVVDKAAE-AGDIEDKY-GSLLTPGKQSG
AQSPAREPASSIHDETLPGGSESEATVSDEENREDQPEEFTATSGYTQSTIEISSEPTPM
DEMSTPRDVMSDETNNEESESPSQEFVNITKYESSLYSQEFTKPKL---PEAFNGLSDGS
KTDATDGKDYNASASTISPPSSMEEDKFSKSILQDAYYAGDRDVKTTATLEIKDGS----
PADEKLSPARSPSLSPAPPSPVAKTPLGERSVNFSLTPNEIKVSAEVGVIP-KSPELPQE
VLEEHCASPEDKTLEVVSPSQSVAGSAGHTPYYQSPTDEKSSHLPTDATEKAPSVPVSFE
FDD-TKDENGKTSISPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYETFLSADIRPSGR
HVESPFEEKIGKQDSPSQISPVSEMTPSGLYQEQQDEK-SAEFMPIKEDLGPEKKMEDFE
AVGSQADLTLDERKLAGDVSPTQIDVSQFGSFKEDTKMSISEGTVSDKSATPVDEGVAED
TYSHIEGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTF
QETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQEHKS-EQSSMSIEFGQESPEQSLAM
DFSRQSPDHPAAGMSVLHISENGPTEVDYSP-DMQESSFSHKIPPAEES-SYAQDNDLSE
LISVSQVEASPSTSSAHTPSQIASPLQEDALSDVVPPREISLYSSLASEKVQGLEGEKLS
PKSDISPLTPRESSPLYSPSFSESTSAFKENAAACRSPSPSPSVGTSSAEPYGFRSSVLF
DTMQHHLSLNSHLPSSGPEK---DQEGKMSDDFSYTYQQTNKTTRSPDE-DDYVYETCEK
TSRSPELGSYSYEKAER

PF00414 // ENSGT00550000074593_0_Domain_6 (2118, 2134)

ITRSPHDSGYSYETIEKTFKTPDDCGFACEITEKTRQTPEEGG
YSYEISEKITRTHEVGEYTHEKMERT-ARLLDDISNGYDDSEDGS

PF00414 // ENSGT00550000074593_0_Domain_12 (2206, 2220)

QTPGDSTYSYETTEK
ITS-FPDSEGYSYETPKRTSQTPESS-PYCYETPEKITRTSQASTYSYETS---------
--------DQC---FSAE--------------KKSPTQARQDVDLCLVSSCEYKHPKTEL
SPSFINPNPLEWFASEEQTQEYEKPLTQAGGGPPPPGGKQQGRQCDETPPTSVSESAPSQ
TDSDVPPETEEFPSITADANIDSEDESETIPTDKTVTYKHIDPPPVPMQDRSPSPRHPDV
S-----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------

------------------------------------------------------------
------------------------------------------------------------
-----MATVVVEATEPEPSGSIANPAASTSPSLSHRFLDSKFYLLVVVGEIVTEEHLRRA
IGNIE-LGIRSWDTNLIECNLDQELKLFVSRHSARFSPEVP-----------GQKILHHR
SDVLETVVLINPSDEAVSTEVRLMITDAARHKLLVLTGQCFENTGELILQSGSFSFQNFI
EIFTDQEIGELLSTTHPANKASLTLFCPEEGDWKNSNLDRHNLQDFINIKLNSASILPEM
EGLSEFTEYLSESVEVPSPFDILEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFNML
INGGSERKSCFWKLIRHLDRVDSILLTHIGDDNLPGINSMLQRKIAELEEEQSQGSTTNS
DWMKNLISPDLGVVFLNVPENLKNPEPNIKMKRSIEEACFTLQYLNKLSMRPEPLFRSVG
NTIDPVILFQKMGVGKLEMYVLNPVKSSKEMQYFMQQW---T-GTN-KDKAE-LILPN-G
QEVD-LPISYL-TSVSS-LIVWHPANPAEKIIRVLFPGNSTQYNILEGLEKLKHLDFLKQ
PLATQKDLTGQVPTPV-VKQTKLKQRADSRESLKPATKPLPS-KSVRKESKEETPEVAKV
NH-VEKPPKVESKEKVTVKKDK------PVKTETKPSVTEKEVPSK--EEPSPVKAEVAE
K---QATDVKPKAAKEKTVKKETKAKPEDKKEE--KEKPKKEVAKKEDKTPIKKEEKPKK
EEVKKEVKKEIKKEEKKEPKKEVKKETPLKEAKKEVKKEEKKEVKKEEKEPKKEIKKLPK
DAKKSSTPLSEAKKPAALKPKVPKKEEPVKKDSV-AAGKPKEKGKVKVIKKEGKATEAVT
A-AV-GTGAATAAVVAAAGIAATGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVTKDI
KPQLELIKDEEKLKETEPVEAYVIQKETEVTKGPAESPDEGITTTEGEGECEQTPEELEP
VEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEEHICVSASKHSPT--
-------E-YEESAKAEADAYI----R-EKRESVASGDDRAEEDMDEAIEKGEAEQSEEE
A--D-EEDKAEDAREEEYEPEK-MEAEDYVMAVVDKAAE-AGGAEEQY-GFLTTPTKQPG
AQSPGREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPM
DEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYSQEYSKPAD---VTPLNGFSEGS
KTDATDGKDYNASASTISPPSSMEEDKFSRSALRDAYCSEVK---ASTTLDIKDTISA--
VSGGKLSPSKSPSLSPSPPSPLEKTPLGERSVNFSLTPNEIKVSAEAEVAP-VSPEVTQE
VVEEHCASPEDKTLEVVSPSQSVTGSAGHTPYYQSPTDEKSSHLPTEVIEKPPAVPVSFE
ISD-AKDDSERASVSPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYESFLSADDKASGR
GAESPFEEKSEKQSSPDQVSPVSEMTSTSLYQDKQEGK-STDFVPIKEDFGQEKKTDDVE
ATSSQPALALDERKLG-DVSPTQIDVSQFGSFKEDTKMSISEGTVSDKSATPVDEGVAED
TYSHMEGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTF
QETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQDHRS-EQSSMSIEFGQESPEHSLAM
DFSRQSPDHPTVGAGVLHITENGPTEVDYSPSDMQDSSLSHKIPPMEEP-SYTQDNDLSE
LISVSQVEASPSTSSAHTPSQIASPLQEDTLSDVAPPRDMSLYASLTSEKVQSLEGEKLS
PKSDISPLTPRESSPLYSPTFSDSTSAVKEKTAACHTSS-SPPIDAASAEPYGFRASVLF
DTMQHHLALNRDLATPGLEK---DSGGKTPGDFSYAYQKPEKTTRSPDE-EDYDYESYEK

PF00414 // ENSGT00550000074593_0_Domain_5 (2101, 2117)

TTRTSDVGGYYYEKIERTTKSPSDSGYSYETIGK

PF00414 // ENSGT00550000074593_0_Domain_7 (2135, 2151)

TTKTPEDGDYSYEIIEKTTRTPEEGG
YSYDISEKTTSPPEVSGYSYEKTERS-RRLLDDISNGYDDSEDG

PF00414 // ENSGT00550000074593_0_Domain_12 (2205, 2220)

GHTLGDPSYSYETTEK
ITS-FPESESYSYETATK

PF00414 // ENSGT00550000074593_0_Domain_14 (2239, 2256)

TTRTPDTS-TYCYETTE

ENSGT00550000074593_0_Linker_14_15 (2256, 2257)

K

PF00414 // ENSGT00550000074593_0_Domain_15 (2257, 2289)

ITRTPQASTYSYETS---------
--------DLC---YTAE--------------KKSPSEARQDVDLCLVSSCEYKHPKTEL
SPSFINPNPLEWFASEEPTEESEKPLTQSGGAPPPPGGKQQGRQCDETPPTSVSESAPSQ
TDSDVPPETEECPSITADANIDSEDESETIPTDKTVTYKHIDPPPAPVQDRSPSPRHPDV
SMVDPEALALEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKSDGKSKPLAASPKPAGL
KESSDKVSRVASPKKKESVEKAAKPT-TTPEVK--AARGEEKDKETKNAANASASKSAKT
AT---A-GPGTTKATKSSTVPPGLPVYLDLCYIPNHSNSKNVDVEFFKRVRSSYYVVSGN
DPAAEEPSRAVLDALLEGKAQWGSNMQVTLIPTHDSEVMREWYQETHEKQQDLNIMVLAS
SSTVVMQDESFPACKIEL

------------------------------------------------------------
------------------------------------------------------------
--------------MATVSGSIANPAATTSPSLSHRFLDSKFYLLVVVGEIVTEEHLRRA
IGNIE-LGIRSWDTNLIECNLDQELKLFVSRHSARFSPEVP-----------GQKILHHR
SDVLETVVLINPSDEAVSTEVRLMITDAARHKLLVLTGQCFENTGELILQSGSFSFQNFI
EIFTDQEIGELLSTTHPANKASLTLFCPEEGDWKNSNLDRHNLQDFINIKLNSASILPEM
EGLSEFTEYLSESVEVPSPFDILEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFNML
INGGSERKSCFWKLIRHLDRVDSILLTHIGDDNLPGINSMLQRKIAELEEEQSQGSTTNS
DWMKNLISPDLGVVFLNVPENLKNPEPNIKMKRSIEEACFTLQYLNKLSMKPEPLFRSVG
NTIDPVILFQKMGVGKLEMYVLNPVKNSKEMQYFMQQW---T-GTN-KDKAE-LILPN-G
QEID-IPISYL-TSVSS-LIVWHPANPAEKIIRVLFPGNSTQYNILEGLEKLKHLDFLKQ
PLATQKDLTGQVATSA-VKQVKLKQRADSRESLKPAAKPLPS-KTVRKESKEETPEVTK-
-G-LEKAPKVESKEKVTVKKDK------PVKTETKPPVTEKETPSK--EELPPAKAEVAE
K---QGTDVKPKVAKEKTVKKETKPKPEEKKEEKEKEKPKKEVAKKEDKTPVKKEEKPKK
EEVKKEVKKEIKKEEKKEIKKEVKKETPLKEAKKEVKKEEKKEIKKEEKEPKKEIKKLPK
DTKKSPTPVAEAKKPAALKPKVPKKEEPVKKESV-AAGKPKEKGKIKVVKKEGKTAEAAA
A-AL-GTVAAAA---AVAGLATTGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVAKDI
KPQLELIEDEEKLKQTEPVEAYVIQKETEVIKGPAESPDEGITTTEGEAECEQTPEELEP
VEKQGVEDTEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDAEDHVRVSTSKHSLA--
-------EE-EDSAKAEADAHI----K-EKRESVASGDDRAEEDMDEALEKGEAEQSEEE
A--E-EEDRAEDAREEDYEPEK-AEAEDYVRAVVDKAAE-ASRAEAEY-GFLTAAPKPGG
AQSPIREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPM
DEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYSQEYAKP-A---VTSLNGLSDGS
KTDATDGRDYNASASTISPPSSMEEDKFSRSALRDAYYSEDKDVRAGAMLEIKDTVSP--
VLDEKLSPPKSPSLSPSPPSPIEKTPLGERSVNFSLTPSEIEVSAEAEVAP-VSPEVTQE
VVEEHCASPEDKTLEVVSPSQSVTGSAGHTPYYQSPTEEKSSHLPTEVIEKPAAVPVSFE
FSD-AKDESERASISPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYESFLSADDKAPGR
GTESPFEGKDGKEASPDQISPVSDMTSTGLLQDKQEGK-STDFIPIKEDFGQEKKTDDVE
DMSSQAGLTLDERKLGGDVSPTQIDVSQFGSLKEDTKMSISEGTVSDKSATPVDEGVVED
TYSHMEGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTF
QETEMSPSKEECPRPMSISPPDFSPKTAKSQTPVQDHRS-EQSSMSIEFGQESPEHSLAM
DFSRQSPDHPTVGAGMLHITENGPTEVDYSPSDMQDSSLSHKIPPTEEP-SYTQDNDLSE
LISVSQVEASPSTSSAHTPSQIASPLQEDTLSDVVPPRDISLYASLTSEKVQSLDAEKLS
PKSDISPLTPRESSPLYSPSFSDSTSAVKESTAACHTAS-PPPMDAASAEPYGFRASMLF
DTMPHHLALNRDLTTPGMEK---DTGGKTPGDFSYAYQKPETTTRSPDE-EGYDYEAYEK

PF00414 // ENSGT00550000074593_0_Domain_5 (2101, 2116)

TTRTPDVSGYYYEKT

ENSGT00550000074593_0_Linker_5_6 (2116, 2119)

ESV

PF00414 // ENSGT00550000074593_0_Domain_6 (2119, 2134)

TKSPCDSSYSYETMEKTSKTPEDDGYAYEITEKTTRSPEESG
YAYEISEK

PF00414 // ENSGT00550000074593_0_Domain_10 (2169, 2185)

TIRTPEVSAYSYEKTERS-RRLLDDISNGYDDSEE

PF00414 // ENSGT00550000074593_0_Domain_12 (2204, 2220)

GGHTLGDSSYSYETTEK
TAG-FPESESYSYEPSTTTTRSPDAS-AYCYETPEKITRAPQASSYAYETS---------
--------DQC---YTAE--------------KKSPSEARQDVDLCLVSSCEYKHPKTEL
SPSFINPNPLEWFASEEPTEESEKPLTQSGGAPPPPGGKPQGRQCDETPPTSVSESAPSQ
TDSDVPPETEECPSITADANIDSEDESETIPTDKTVTYKHMDPPPAPMQDRSPSPRHPDV
SMMDPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKSDGKSKPSAASPKPGAL
KESSDKVSRVASPKKKESVEKATKTT-TTPEVK--AARGEEKDKETKNAANASTSKSVKT
AT---A-GPGTTKTSKPSAVPPGPPVYLDLCYIPNHSNSKNVDVEFFKRVRSSYYVVSGN
DPAAEE------------------------------------------------------
------------------

------------------------------------------------------------
------------------------------------------------------------
-----MATVVVEATEPEPSGSIANPAASTSPSLSHRFLDSKFYLLVVVGEIVTEEHLRRA
IGNIE-LGIRSWDTNLIECNLDQELKLFVSRHSARFSPEVP-----------GQKILHHR
SDILETVVLINPSDEAVSTEVRLMITDAARHKLLVLTGQCFENTGELILQSGSFSFQNFI
EIFTDQEIGELLSTTHPANKASLTLFCPEEGDWKNSNLDRHNLQDFINIKLNSASILPEM
EGLSEFTEYLSESVEVPSPFDILEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFNML
INGGSERKSCFWKLIRHLDRVDSILLTHIGDDNLPGINSMLQRKIAELEEEQSQGSTTNS
DWMKNLISPDLGVVFLNVPENLKNPEPNIKMKRSIEEACFTLQYLNKLSMKPEPLFRSVG
NTIDPVILFQKMGVGKLEMYVLNPVKSSKEMQYFMQQW---T-GTN-KDKAE-FILPN-G
QEVD-LPISYL-TSVSS-LIVWHPANPAEKIIRVLFPGNSTQYNILEGLEKLKHLDFLKQ
PLATQKDLTGQVPTPV-VKQTKLKQRADSRESLKPATKPLPS-KTVRKESKEEPPEVTKV
NH-VEKPPKVESKEKVTVKKDK------PVKTETKPSVTEKEVPSK--EEPSPVKAEVAE
K---QATDVKPKAAKEKTVKKETKVKPEDKKEE--KEKPKKEVAKKEDKTPIKKEEKPKK
EEVKKEVKKEIKKEEKKEPKKEVKKETPPKEAKKEVKKEEKKDVKKEEKEPKKEIKKLPK
DSKKSSTPLSEAKKPAALKPKVPKKEESVKKDSV-ATGKPKEKGKIKVIKKEGKAAEAVA
A-AV-GTGAT--TAAAAAGIAATGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVTKDI
KPQLELIEDEEKLKETEPVEAYIIQKEIEVTKGSAESPDEGITTTEGEGECEQTPEELEP
VEKPGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEEHVCVSTSKHSPT--
-------ED-EESAKAEADAYI----R-EKRESVASGDDRAEEDMDEAIEKGEAEQSEEE
A--D-EEDKAEDAREEEYEPEK-IEAEDYVMAVVDKAAE-AGGAEEQY-GFLTTPTKQPG
SQSPGREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPM
DEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYSQEYSKPAA---VTPLNGFSEGS
KTDATDGKDYNASASTISPPSSMEEDKFSRSALRDAYCPEVK---ASPTLDIKDAISA--
VSGEKLSPSKSPSLSPSPPSPIEKTPLGERSVNFSLTPNEIKVSAEAEVAP-VSPEVTQE
VVEEHCASPEDKTLEVVSPSQSVTGSAGHTPYYQSPTEEKSSHLPTEVIEKPPAVPVSFE
FSD-AKDENERASVSPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYESFLSADGKASGR
GAESPFEEKSGKQGSPDQISPVSEMTSTSLYQDKQEGK-GTDFVPIKEDFGQEKKIDDGE
AMSAQPALALDERKLG-EVSPTQIDVSQFGSLKEDTKMSISEGTVSDKSATPVDEGVAED
TYSHMEGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTF
QETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQDHRS-EQSSMSIEFGQESPEHSLAM
DFSRQSPDHPTVGAGVLHITENGPTEVDYSPSDMQDSSLSHKIPPMEEP-SYTQDNDLSE
LISVSQVEASPSTSSAHTPSQIASPLQEDTLSDVAPPRDMSLYASLTSEKVRSLEGEKLS
PKSDISPLTPRESSPLYSPTFSDSTSAVKEKTAACHTSS-SPPIDAASTEPYGFRASVLF
DTMQHHLALNRDLATPGME----DSGGKTPGDFSYAYQKPEKTTRSSDE-EDYDYESYEK

PF00414 // ENSGT00550000074593_0_Domain_5 (2101, 2117)

TTRTSDVGGYYYEKTERTTKSPSDSGYSYETIGK

PF00414 // ENSGT00550000074593_0_Domain_7 (2135, 2151)

TTKTPEDGDYSYEIIE

ENSGT00550000074593_0_Linker_7_9 (2151, 2152)

K

PF00414 // ENSGT00550000074593_0_Domain_9 (2152, 2168)

TTRTPEEGG
YSYEISEKTTSPPEMSGYSYEKTERS-RRLLDDISNGYDDSEDG

PF00414 // ENSGT00550000074593_0_Domain_12 (2205, 2220)

GHTLGDPSYSYETTEK
ITS-YPESESYSYETSTK

PF00414 // ENSGT00550000074593_0_Domain_14 (2239, 2256)

TTRTPDAS-TYCYETTEKITGTPQASTYSYETS---------
--------DLC---YSAE--------------KKSPSEARQDVDLCLVSSCEYKHPKTEL
SPSFINPNPLEWFASEEPTEESEKPLTQSGGAPPPPGGKQQGRQCDETPPTSVSESAPSQ
TDSDVPPETEECPSITADANIDSEDESETIPTDKTVTYKHMDPPPAPVQDRSPSPRHPDV
SMVDPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKSDGKSKPLAASPKPGGL
KESSDKVSRVASPKKKESVEKAAKPT-TTPEVK--AARGEEKDKETKNAANASASKSAKT
ATA----GPGTTKTTKSSTVPPGLPVYLDLCYIPNHSNSKNVDVEFFKRVRSSYYVVSGN
DPAAEEPSRAVLDALLEGKAQWGSNMQVTLIPTHDSEVMREWYQETHEKQQDLNIMVLAS
SSTVVMQDESFPACKIEL

------------------------------------------------------------
------------------------------------------------------------
-----MATVVVEATEPEPSGSIANPAVSTSPSLSHRFLDSKFYLLVVVGEIVTEEHLRRA
IGNIE-LGIRSWDTNLIECNLDQELKLFVSRHSARFSPEVP-----------GQKILHHR
SDILETVVLINPSDEAVSTEVRLMITDAARHKLLVLTGQCFENTGELILQSGSFSFQNFI
EIFTDQEIGELLSTTHPANKASLTLFCPEEGDWKNSNLDRHNLQDFINIKLNSASILPEM
EGLSEFTEYLSESVEVPSPFDILEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFNML
INGGSERKSCFWKLIRHLDRVDSILLTHIGDDNLPGINSMLQRKIAELEEEQSQGSTTNS
DWMKNLISPDLGVVFLNVPENLKNPEPNIKMKRSIEEACFTLQYLNKLSMKPEPLFRSVG
NTIDPVILFQKMGVGKLEMYVLNPVKNSKEMQYFMQQW---T-GTN-KDKAE-LILPS-G
QEVD-IPISYL-TSVSS-LIVWHPANPAEKIIRVLFPGNSTQYNILEGLEKLKHLDFLKQ
PLATQKDLTGQVATPA-VKQVKLKQRADSRESLKPATKPLPS-KSVRKESKEETLDITKA
NL-VEKPPKVESKEKVTVKKDK------PTKIDTKPSVSEKEVPSK--EDQPSVKTEVAE
K---QATDVKPKVTKEKTVKKETKPKPEEKKEE--KEKPKKEVAKKEDKTPVKKEEKTKK
EEVKKE----IKKEEKKESKKEVKKETPLKEAKKEVKKEEKKEVKKEEKEPKKEIKKISK
DVKKPSTPLPEAKKPAALKPKVPKKEEPVKKDAV-AAGKPKEKGKIKVIKKEGKTTEAAA
A-AI-STVAAAEAMSVAAGIEATGPAKEL

PF00183 // ENSGT00550000074593_0_Domain_1 (990, 1015)

EAERSLMSSPEDLTKDFEELKAEEV

ENSGT00550000074593_0_Linker_1_2 (1015, 1490)

DVAKDI
KPQLELIEDEEKLKETEPVEAYVIQKETEVIKGPAESPDEGITTTEGEGECEQTPEELEP
VEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEESMYMRT-KHSPT--
-------ED-EESVKAEADVHI----K-EKRESVASGDDRAEEDMDEAVEKEEAEQSEEE
G--D-EEDKAEDSREEEYEPEK-IEAEDYVMAVVDKAAE-AGGAEDQY-GFLTTSTKQLG
AQSPVQEPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPM
DEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYSQEYPKP-----VTSLNGLSDVS
KTDATEGKDYSVSASTISPPSSMEEDKFSRSALRDAYCSEEKEMKASVTLEIKDT-SA--
VSDEKLSPSKSPSLSPSPPSPIEKTPLGERSVNFSLMPNEIKVSAEA-A

PF02818 // ENSGT00550000074593_0_Domain_2 (1490, 1516)

AP-VSPEVTQE
VVEEHFASPEDKTLEVVSPSQSVTGSAGHTPYYQSPTDEKSSHLPTEVIEKPPAVPVSFE
FDD-AKDDNEKPSISPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYESFLNADGKTPDR
CTESPFEGTIGEQGSPDQISPASEITSTGLFQEKQEEK-SADFIPIKEDFGEEKKTDDVE
AMSSQPGLALDERKLGGDVSPTQIDVSQFGSFKEDTKMSISEGTVSDKSATPVDEGVAED
TYSHMEGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTF
QETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQDHRS-EQSSMSIEFGQESPEHSLAM
DFSRQSPDQPTVGVGMLHITENGPTEVDYSPSDLQDSSLSHKIPPTEEP-SYTQDNDLSE
LISVSQVEASPSTSSAHTPSQIASPLQEDTLSDVVPPRDISLYASLTSEKVQSLEGEKLS
PKSDISPLTPRESSPLYSPSFSDSTSAVKESAAACHTSS-SPSVDAASAEPYSFRASMLF
DTMQHHLALDRDLTTSGLE----DSGGRTPGDFSYAYQKPEKTARSPGE-ES--YESYEK

PF00414 // ENSGT00550000074593_0_Domain_5 (2101, 2117)

THQTPDVGGYYYEEAE

ENSGT00550000074593_0_Linker_5_6 (2117, 2118)

R

PF00414 // ENSGT00550000074593_0_Domain_6 (2118, 2134)

TTKSPCDSGYSYETVE

ENSGT00550000074593_0_Linker_6_7 (2134, 2135)

K

PF00414 // ENSGT00550000074593_0_Domain_7 (2135, 2149)

TSKTPEDDGYAYEI

ENSGT00550000074593_0_Linker_7_9 (2149, 2152)

T-K

PF00414 // ENSGT00550000074593_0_Domain_9 (2152, 2168)

TTRTPEEGG
YSYEISE

ENSGT00550000074593_0_Linker_9_10 (2168, 2169)

K

PF00414 // ENSGT00550000074593_0_Domain_10 (2169, 2185)

TTRTPEVSGYSYEKTERS-SRLLDDISNGYDDTED

PF00414 // ENSGT00550000074593_0_Domain_12 (2204, 2220)

GGHTLGDSSYSYETTEK
ITA-FPESESYSYETP---

PF00414 // ENSGT00550000074593_0_Domain_14 (2240, 2256)

TKTPDTS-AYCYETTE

ENSGT00550000074593_0_Linker_14_15 (2256, 2257)

K

PF00414 // ENSGT00550000074593_0_Domain_15 (2257, 2290)

ITRTPQASTYSYETS---------
--------DQC---YTAE--------------KKSPSEARQDVDLCLVSSCEYKHPKTEL
SPSFINPNPLEWFASEEPTEESEKPLIQSGGAPPPPGGKQQGRQCDETPPTSVSESAPSQ
TDSDVPPETEECPSITADANIDSEDESETIPTDKTVTYKHMDPPPAPMQDRSPSPRHPDV
SMVDPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKGDGKSKPSAASPKPVGL
KESSDKVSRVASPKKKESVEKATKPT-TAPEVK--TARGEDK--ETKNATNTSTSKSVKT
ATA----GPGTTKTAKSSAVPPGPPVYLDLCYIPNHSNSKNVDVEFFKRVRSSYYVVSGN
DPAAEEPSRAVLDALLEGKAQWGSNMQVTLIPTHDSEVMREWYQETHEKQQDLNIMVLAS
SSTVVMQDESFPACKIEL

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------GQKILHHR
SDVLETVVLINPSDEAVSTEVRLMITDAARHKLLVLTGQCFENTGELILQSGSFSFQNFI
EIFTDQEIGELLSTTHPANKASLTLFCPEEGDWKNSNLDRHNLQDFINIKLNSSSILPEM
EGLSEFTEYLSESVEVPSPFDILEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFNML
INGGSERKSCFWKLIRHLDRVDSILLTHIGDDNLPGINSMLQRKIAELEEEQSQGSTTNS
DWMKNLISPDLGVVFLNVPENLKNMDPSFRVKRSVEEACFTLQYLNKLSMKPEPLFRNVG
NTIDPIILFQKMGVGKLEMYVLNPVKSSKEMQYFMHQW---S-GTS-KDKAE-FLLPN-G
QELD-IPLSYF-TSVSS-LIVWHPANPAEKIIRVLFPGNSTQYNILEGLEE---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------ISSEPTPM
DEMSTPRDVMSDETNNEESESPSQEYVNITKYETSLYSQEFGRPKLSPLPDAFNGLSEGS
KTEATEGKDYNASASTISPPSSLEEDKFCKSAFQDVYRQKESE---TAKLEIKETCPEDV
DVTGKRSPAKSPADSLSPPSPVAKTPLSERSVNFSLTPNEIKVSAETASVT-ALPSVHQE
IAEEHCASPEDKTLEVASPSQSAAGSAGHTPYYQSPTDEKSSQLPSETSEKSSEAPVSVE
FSE-VKDESAKPRISPMDEPVPDSESPIEKVLSPLRSPPLIGSETSYDMFLSADVRSPPR
DYGSPSEEKPEKEKSPVQMSPSSEASSVGLFQEKQDEK-SMEFMVIKEGFSLERKTEDTE
PSSSQSSLVLDERKLTGDLSPTQIDISQFGSLKEDTKMSISEGTVSDKSATPVDEVVAED
TYSHIEGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTF
QETEMSPSKEECPRPMSISPPDFSPKTAKSGTPVHDHRSPEQSTMSVEFGQESPEQSLAM
DFSRQSPEYPTAGTGIHHISENGPTEVDYSPSDIQEPTFARKISPLEHT-SYSQEKDISE
IISVSQIEASSSSSSAHTPSQVTSPLPEETFSGVVPPRDISLH-SFTSEKVQSL-GEKLS
PKSDLSPLTPRESSPLYSPTFPDSPPAVTEAVSASHASPLS--LQVSSDKVFGYQAVTLQ
ETLTK----HSPEPLFSPEKEDSEK

PF00414 // ENSGT00550000074593_0_Domain_3 (2066, 2082)

SSRSPEELSYSYEATE

ENSGT00550000074593_0_Linker_3_4 (2082, 2083)

K

PF00414 // ENSGT00550000074593_0_Domain_4 (2083, 2100)

TTRSPED-ISYSYEAVG

ENSGT00550000074593_0_Linker_4_5 (2100, 2101)

R

PF00414 // ENSGT00550000074593_0_Domain_5 (2101, 2117)

STRSPQATDYSYETTG

ENSGT00550000074593_0_Linker_5_6 (2117, 2118)

K

PF00414 // ENSGT00550000074593_0_Domain_6 (2118, 2134)

ITRSPEATDYSYEMRG

ENSGT00550000074593_0_Linker_6_7 (2134, 2135)

K

PF00414 // ENSGT00550000074593_0_Domain_7 (2135, 2151)

ITRSPDATDYSYDLTQ

ENSGT00550000074593_0_Linker_7_9 (2151, 2152)

K

PF00414 // ENSGT00550000074593_0_Domain_9 (2152, 2168)

TTVSPGDTD
YSYEMTQ

ENSGT00550000074593_0_Linker_9_10 (2168, 2169)

K

PF00414 // ENSGT00550000074593_0_Domain_10 (2169, 2185)

TTRSPGDTEFSYEMTR

ENSGT00550000074593_0_Linker_10_11 (2185, 2186)

K

PF00414 // ENSGT00550000074593_0_Domain_11 (2186, 2203)

AT-RSPDDTDYSYEGIGKGTQSLDALDS-------
-----------SYETMGKITESPEA-ISYCYDRSGR

PF00414 // ENSGT00550000074593_0_Domain_16 (2257, 2273)

TTRSPEATDYSFETTEKATRSPEA
TGYSYEASAH-------------------FTPGKSLAESRQDVDLCLVSSCEYKHPKTEL
SPSFINPNPLEWFASEEQSQDQEKLLTQSGGAQPPSGGKQQGRQCDETPPTSVSESAPSQ
TDSDVPPETEECPSITADANIDSEDESETIPTDKTITYRHIDPPPVPMQDRSPSPRHPDV
SMVDPEALPIDQNLGKPLKKDLKEKAKTKKTGTKTKSSSPVKKSDGKSKQVA-SPKP-AA
KDSLEKSSKTASPKKKESVEKASKNI-STPEVK---TRVEEKDKDTKNAVNTTASKSAKT
ATTG--------------------------------------------------------
------------------------------------------------------------
------------------

MTSARAAGC--RR-------GGSRRVRMCRVVPAS-------SSSSSSRLAARAPYKSGA
ASPPARSARSAPPRAPGRAEGRRRGAGRGAGGGARAAPRRPSLSC--SRRAG-RRAARAA
QRAGRMATVVLEAAEPEPAGGIANPAASTSPSLSHRFLDSKFYLLVVVGEIVTEEHLRRA
IGNIE-LGIRSWDTNLIECNLDQELKLFVSRHSARFSPEVP-----------GQKILHHR
SDVLETVVLINPSDEAVSTEVRLMITDAARHKLLVLTGQCFENTGELILQSGSFSFQNFI
EIFTDQEIGELLSTTHPANKASLTLFCPEEGDWKNSNLDRHNLQDFINIKLNSASILPEM
EGLSEFTEYLSESVEVPSPFDILEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFNML
INGGSERKSCFWKLIRHLDRVDSILLTHIGDDNLPGINSMLQRKIAELEEEQSQGSTTNS
DWMKNLISPDLGVVFLNVPENLKNPEPNIKMKRSIEEACFTLQYLNKLSMKPEPLFRSVG
NTIDPVILFQKMGVGKLEMYVLNPVKSSKEMQYFMQQW---T-GTN-KDKAE-LILPN-G
QEID-IPISYL-TSVSS-LIVWHPANPAEKIIRVLFPGNSTQYNILEGLEKLKHLDFLKQ
PLATQKDLTGQVAAPA-VKQVKLKQRADSRESLKPAAKPLPS-KSVRKESKEETPEVTKA
NH-VEKPPKVESKEKVTVKKDK------PVKTETKPPVTEKEVPSKEKEELPPVKAEVAE
K---PTTDVKPKVTKEKTVKKETKAKSEEKKEE--KEKPKKEVAKKEDKTPIKKEEKPKK
EEVKKEVKKEVKKEEKKEPKKEVKKETPLKEAKKEVKKEEKKEIKKEEKEPKKEIKKLPK
DTKKSTTPLSEAKKPAALKPKVPKKEEAVKKESV-AAGKPKEKGKVKVVKKEGKTAEAAA
A-AL-GSVAGAAA-VAAAGAAGASSAKELEAERSLMSSPEDLTKDFEELKAEEVDVAKDM
KPQLELIEDEEKLKDAEPVEAYVLQKETEVIKGPAESPDEGITTTEGEGECEQTPEELEP
VEKQGVEDTEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDVEETVCVSTSKHSLT--
-------EE-EESAKAEADVHV----K-EKRESLASGDDRAEEDMDEAVEKGEAEQSEEE
G--E-EEDRAEDAREEEYEPEK-AEAEDYVMAVVDKAAE-ASGVEDQY-GFLASAIKQPG
AQSPAREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPM
DEMSTPRDVMSDEINNEETESPSQEFVNITKYESSLYSQEYGKP-A---VASLNGLSEGS
KTDATDGKDYNASASTISPPSSMEEDKFSKSALRDAYCADEKDLKAGATLAIRDTISA--
VSEEKLSPPKSPSPSPSPPSPVEKTPLGERSVNFSLTPNEIQVSAEAEAAP-VSPEVTQ-
VVEEHCASPEEKTLEVVSPSQSATGSAGHTPYYQSPTEEKSGHLPTEVIEKPQAVPVSFE
FSD-AKDENERASISPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYEGFLSADDQASGR
GAESPFEGKDGKQGFADEISPVSDMTSTGLFQDKEERK-STDFIPIKEDFGQEKKTDDVD
VTSSQSGLALDERKLGGEVSPTQIDVSQFGSFKEDTKMSISEGTVSDKSATPVDEGVAED
TYSHMEGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTF
QETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQDHRS-EQSSMSIEFGQESPEHSLAM
DFSRQSPDHPTVGAGMLHITENGPTEVDYSPSDMQDSSLSHKIPPMEEP-SYTQDNDLSE
LISVSQVEASPSTSSAHTPSQIASPLQEDTLSDVVPPRDISLYASLTSEKVQSLEGEKLS
PKSDISPLTPRESSPLYSPSFSDSTSAVKENIAVCHTSS-PPPMDAASAEPYGFRASMLF
DTMQHQLALNRDLTSSGVE----DSGGKTPGDFSYAYQKPEKTTRSPDE-EVYDYESYEK

PF00414 // ENSGT00550000074593_0_Domain_5 (2101, 2117)

ATRPPDVSDYYYEKTERTTKSPCDSSYPYETTEKTTKTPEDGGYAYDIAEKTTRTPEEAE
YSYETSEKTMRTPEVSGFSYEKTERS-RRLLDDISNGYDDSEDVGHALGDSGYSYKTTEK
IAS-YPEPESYSYEASTT

PF00414 // ENSGT00550000074593_0_Domain_14 (2239, 2256)

ATRAPDAS-TYCYETAEKITRTPQAATYSYETS---------
--------DQC---YTAE--------------KKSPSEARQDVDLCLVSSCEYKHPKTEL
SPSFINPNPLEWFASEEPTEESEKPLTQAGGAPPPPGGKPQGRQCDETPPTSVSESAPSQ
TDSDVPPETEECPSITADANIDSEDESETIPTDKTVTYKHMDPPPAPMQDRSPSPRHPDV
SMMDPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKGDGKSKPSAASPKPGGL
KESSDKVSRVASPKKKESVEKATKTT-TTPEVK--AARGEEKDKDTKNAANASTSKSVKT
AA---A-GPGTTKPSKPSAVPPGPPVYLDLCYIPNHSNSKNVDVEFFKRVRSSYYVVSGN
DPAAEEPSRAVLDALLEGKAQWGSNMQVTLIPTHDSEVMREWYQETHEKQQDLNIMVLAS
SSTVVMQDESFPACKIEL

------------------------------------------------------------
------------------------------------------------------------
-----MATVVVETAEPEPSGSLANPAASTSVSLSHRFLDSKFYXXXXXXXXXXXXXXXXX
XXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-----------XQKILHHR
SDILETVVLINPSDEAVSTEVRLMITDAARHKLLVLTGQCFENTGELILQSGSFSFQCFI
EIFTDQEIGELLSTTHPANKASLTLFCPEEGDWKNSNLDRHNLQDFINIKLNSASILPEM
EGLSEFTEYLSESVEVPSPFDILEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFNML
INGGSERKSCFWKLIRHLDRVDSILLTHIGDDNLPGINSMLQRKIAELEEEQSQGSTTNS
DWMKNLISPDLGVVFLNVPENLKNPEPNIKMKRSIEEACFTLQYLNKLSMKPEPLFRSVS
NTIEPVILFQKMGVGKLEMYVLNPVKSSKEMQYFMQQW---T-GTN-KDKAE-LILPS-G
QEID-IPISYL-TSVSS-LIVWHPANPAEKIIRVLFPGNSTQYSILEGLEKLKHLDFLKQ
PLATQKDLTGQVATPA-VKQAKLKQRADSRESLKPVTKPLAS-KSVRKESKEETPEVTKA
NH-VEKPPKVESKEKVIVKKDK------PVKTETKPTLIEKEVSSK--EEQPPVKAELTE
K---PATDVKPKVTKEKTVKKEIKAKPEEKKEE--KEKPKKEVAKKEDKTPIKKEEKTKK
EEVKKEVKKEIKKEEKKELKKEVKKDTPLKDAKKEIKKDEKKDIKKEEKEPKKEIKKIPK
DTKKSSTPLSEAKKPAVLKPKVPKKEEAVKKD-SVATGKLKDKGKVKVIKKEGKMTEAAA
A-AT-GTTATA----ALVTAATTGPAKDL

PF00183 // ENSGT00550000074593_0_Domain_1 (990, 1015)

EAERSLMSSPEDLTKDFEELKAEEVDVAKDI
KPQLELIEDEEKLKETEPVKAYVIQ-ETEVIKGPAESPDEGITTTEGEGECEQTPEELEP
VEKQGVEDTEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGDENICVNTSKHSPL--
--------EEEESVKAEDDVHI----K-EKRESVASGDDRAEEDMDEAVEKGEAEQSEEE
GD---EEDKAEGVREEEYESEK-AEAEDYVMAVVDKAAGA-SGLEDQY-GFLTPSAKPVG
SQSPLQEPASXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXX----XXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--
XXXXXXXXXXXXXXXX---XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXX-XXXXXXXXXX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXX
XXXXXXXXXXXXXXPSTSSDQIASPLQEDALSDV-PPRDMSLYASLTSEKVQSLEGEKLS
PKSDISPLTPRQSSPLYSPSFSDSTSAVKENIAT-CHTPSLPPMDTASTEPYDFRASMLF
DSMQHHLALDTDLTTSGIEK---DS

PF00414 // ENSGT00550000074593_0_Domain_3 (2066, 2082)

GGKTPGDFSYAYQKSE

ENSGT00550000074593_0_Linker_3_4 (2082, 2083)

K

PF00414 // ENSGT00550000074593_0_Domain_4 (2083, 2100)

TTRSPDE-EGYDYESYE

ENSGT00550000074593_0_Linker_4_5 (2100, 2101)

K

PF00414 // ENSGT00550000074593_0_Domain_5 (2101, 2117)

TTRTPDVSGYYYEKVE

ENSGT00550000074593_0_Linker_5_6 (2117, 2118)

R

PF00414 // ENSGT00550000074593_0_Domain_6 (2118, 2134)

TTKSPSGGGYSYETIE

ENSGT00550000074593_0_Linker_6_7 (2134, 2135)

K

PF00414 // ENSGT00550000074593_0_Domain_7 (2135, 2151)

TVKTPEDGGYAYEITE

ENSGT00550000074593_0_Linker_7_9 (2151, 2152)

K

PF00414 // ENSGT00550000074593_0_Domain_9 (2152, 2168)

TTRTPEEGG
YSYEISE

ENSGT00550000074593_0_Linker_9_10 (2168, 2169)

K

PF00414 // ENSGT00550000074593_0_Domain_10 (2169, 2185)

TIRTPEVSGYSYEKTERS-RRLLDDISNGYDDSED

PF00414 // ENSGT00550000074593_0_Domain_12 (2204, 2220)

GGHTLGDCSYSYETSEK
ISN-FPESESYSYEKSTK

PF00414 // ENSGT00550000074593_0_Domain_14 (2239, 2256)

TTRTPDTS-TYCYETAE

ENSGT00550000074593_0_Linker_14_15 (2256, 2257)

K

PF00414 // ENSGT00550000074593_0_Domain_15 (2257, 2290)

ITRTPQESTYSYETS---------
--------DQC---YTAE--------------KKSPSEARQDVDLCLVSSCEYKHPKTEL
SPSFINPNPLEWFASEEPTEESERPLTQSGGAPPPPGGKPQGRQCDETPPTSVSESAPSQ
TDSDVPPETEECPSITADANIDSEDESETIPTDKTVTYKHMDPPPASMQDRSPSPRHPDV
SMMDPEALAIEQNLGKSLKKDLKEKTKTKKPGTKTKSSSPVKKADGKSKPSAASPKPGGL
KESLDKVSRVASPKKKESVEKATKTT-AFFF--FSSPCGEEKDKETKNATNASTSKSVKT
AT----AGPGTTKTAKPSAVPPGPPIYLDLCYIPNHSNSKNIDVEFFKRVRSSYYVVSGN
DPAAEEPSRAVLDALLEGKAQWGSNMQVTLIPTHDSEVMREWYQETHEKQQDLNIMVLAS
SSTVVMQDESFPACKIEL

------------------------------------------------------------
------------------------------------------------------------
-----MATVVVEATEPEPSGSIANPAASTSPSLSHRFLDSKFYLLVVVGETVTEEHLRRA
IGNIE-LGIRSWDTNLIECNLDQELKLFVSRHSARFSPEVP-----------GQKILHHR
SDVLETVVLINPSDEAVSTEVRLMITDAARHKLLVLTGQCFENTGELILQSGSFSFQNFI
EIFTDQEIGELLSTTHPANKASLTLFCPEEGDWKNSNLDRHNLQDFINIKLNSASILPEM
EGLSEFTEYLSESVEVPSPFDILEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFNML
INGGSERKSCFWKLIRHLDRVDSILLTHIGDDNLPGINSMLQRKIAELEEEQSQGSTTNS
DWMKNLISPDLGVVFLNVPENLKNPEPNIKMKRSIEEACFTLQYLNKLSMKPEPLFRSVG
NTIDPVILFQKMGVGKLEMYVLNPVKSSKEMQYFMQQW---T-GTN-KDKAE-LILPN-G
QEVD-IPISYL-TSVSS-LIVWHPANPAEKIIRVLFPGNSTQYNILEGLEKLKHLDFLKQ
PLATQKDLTGQVPTPT-VKQVKLKQRADSRESLKPAAKPLAS-KSVRKESKEETPEVTKA
NQ-VEKPPKVESKEKVIVKKDK------PVKTETKPPVTEKEAPSK--EEQPPAKTDVAE
K---QATDVKPKTAKEKIVKKEIKTKPEEKKEE--KEKPKKEVAKKEDKTPAKKEEKPKK
EEVKKEVKKEVKKEEKKEPKKEVKKETPLKDAKKEGKKEEKKDLKKEEKEPKKEIKKLSK
DSKKPSTPLSEAKKPAALKPKVPKKEEPVKKESV-AAGKPKEKGKIKVVKKEGKTAEAAA
A-VV-GTVATTAAAVAAAGIAATGPAKELEAERSLMSSPEDLTKDFEELKAEEIDVAKDI
KPQLELIEDEEKLKGTEPVDAYVLQKETEVSKGSAESPDEGITTTEGEGECEQTPEELEP
VEKPGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEENVCT--SKHSPT--
-------ED-EESAKAEADVHI----K-EKRESVASGDDRAEEDMDEAIEKGEAEQSEEE
E--A-EEEDKAEDARDEYEPEK-MEAEDYVMAVVDKAAE-AGGAEDQY-GFLTTSAKQPG
VQSPGREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPM
DEMSTPRDVMSDETNNEETESPSQEFINITKYESSLYSQEYSKT-T---VTPFNGLSDGS
KTDATEGKDYNASASTISPPSSMEEDKFSKSALRDAYYSEEKEVKASATLEIKDTVSP--
VSDEKLSPAKSPSSSPSPPSPVEKTPLGERSVNFSLTPNEIKVSTEAEVVP-VSPEVTQE
VVEEHCASPEEKTLEVVSPSQSVTGSAGHTPYYQSPTEEKAGHLPAEVTEKPAAVPVSFE
FSD-AKDESERASISPMDEPVPDSESPMEKVLSPLRSPPLIGSESAYESFLSADDKAPGR
RAQSPFEGKNGKQDFADQVSPVSEMTPPGLYQDKQEVR-STDFTPIKEDFGPEKKTGDVE
AMSSQPALALDERKLGGEVSPTQIDVSQFGSFKEDTKMSISEGTVSDKSATPVDEGVAED
TYSHMEGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTF
QETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQDHRS-EQSSMSIEFGQESPEHSLAM
DFSRQSPDHPAVGASMLHITENGPTEVDYSPSDMQDSSLSHKIPPTEEQ-SYTQDNDLSE
LISVSQVEASPSTSSAHTPSQIASPLQEETLSDVAPPREMSLYASLTSEKEQSLEGEKLS
PRSDISPLTPRESSPLYSPGFSDSTSAGKESTTACHTSS-SPPLDAASAEPFGYRASMLF
DTMQHHLALNRDLAASGMEN---DNGGKTPGDFSYVYQKSEKTTRSPDE-EDYDYEPSEK

PF00414 // ENSGT00550000074593_0_Domain_5 (2101, 2117)

TTRTPDVGSYYYEKTERTVKSAYDSGYSYETIEKTIKTPEDGGYACEITEK

PF00414 // ENSGT00550000074593_0_Domain_9 (2152, 2168)

TTRTPEEGG
YSYEISE

ENSGT00550000074593_0_Linker_9_10 (2168, 2169)

K

PF00414 // ENSGT00550000074593_0_Domain_10 (2169, 2185)

TTRTPEVSGYSYEKTERA-RRLLDDISNGYDDSEEGGHTLGDASYSYETTEK
ISS-FPESESYSYETSTK

PF00414 // ENSGT00550000074593_0_Domain_14 (2239, 2256)

TAKSPDSS-TYCYETME

ENSGT00550000074593_0_Linker_14_15 (2256, 2257)

R

PF00414 // ENSGT00550000074593_0_Domain_15 (2257, 2290)

ITKTPQASTYSYETS---------
--------DRC---YTAE--------------KKSPSEARQDVDLCLVSSCEYKHPKTEL
SPSFINPNPLEWFASEEPTEESEKPLTQSGGAPPPPGGKQQGRQCDETPPTSVSESAPSQ
TDSDVPPETEECPSITADANIDSEDESETIPTDKTVTYKHMDPPPAPMQDRSPSPRHPDV
SMVDPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKGDGKSKPSAASPKPGAL
KDTSDKVSRVASPKKKESVEKATKTT-ATPEVK--AVRGEEKDKETKNAANASASKSAKT
AT---A-GPGATKTTKSSAVPPGLPVYLDLCYIPNHSNSKNVDVEFFKRVRSSYYVVSGN
DPAAEEPSRAVLDALLEGKAQWGSNMQVTLIPTHDSEVMREWYQETHEKQQDLNIMVLAS
SSTVVMQDESFPACKIEL

------------------------------------------------------------
------------------------------------------------------------
-----MATVVVEATEPEPSGSIANPAASTSPSLSHRFLDSKFYLLVVVGEIVTEEHLRRA
IGNIE-LGIRSWDTNLIECNLDQELKLFVSRHSARFSPEVP-----------GQKILHHR
SDVLETVVLINPSDEAVSTEVRLMITDAARHKLLVLTGQCFENTGELILQSGSFSFQNFI
EIFTDQEIGELLSTTHPANKASLTLFCPEEGDWKNSNLDRHNLQDFINIKLNSASILPEM
EGLSEFTEYLSESVEVPSPFDILEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFNML
INGGSERKSCFWKLIRHLDRVDSILLTHIGDDNLPGINSMLQRKIAELEEEQSQGSTTNS
DWMKNLISPDLGVVFLNVPENLKNPEPNIKMKRSIEEACFTLQYLNKLSMRPEPLFRSVG
NTIDPVILFQKMGVGKLEMYVLNPVKSSKEMQYFMQQW---T-GTN-KDKAE-LILPN-G
QEVD-LPISYL-TSVSS-LIVWHPANPAEKIIRVLFPGNSTQYNILEGLEKLKHLDFLKQ
PLATQKDLTGQVPTPV-VKQTKLKQRADSRESLKPATKPLPS-KSVRKESKEETPEVTKV
NH-VEKPPKVESKEKVTVKKDK------PVKTETKPSVTEKEVPSK--EEPSPVKAEVAE
K---QATDVKPKAAKEKTVKKETKAKPEDKKEE--KEKPKKEVAKKEEKTPIKKEEKPKK
EEVKKEVKKEIKKEEKKEPKKEVKKETPLKEAKKEVKKEEKKEVKKEEKEPKKEIKKLPK
DAKKSSTPLSEAKKPAALKPKVPKKEEPVKKDSV-AAGKPKEKGKIKVIKKEGKATEAVA
A-AV-GTGAATAAVVAAAGIAATGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVTKDI
KPQLELIEGEEKLKETEPVEAYVIQKETEVTKGPAESPDEGITTTEGEGECEQTPEELEP
VEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEEHICVSASKHSPT--
-------E-YEESAKAEADAYI----R-EKRESVASGDDRAEEDMDEAIEKGEAEQSEEE
A--D-EEDKAEDAREEEYEPEK-MEAEDYVMAVVDKAAE-AGGAEEQY-GFLTTPTKQPG
AQSPGREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPM
DEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYSQEYSKPAD---VTPLNGFSEGS
KTDATDGKDYNASASTISPPSSMEEDKFSRSALRDAYCSEVK---ASTTLDIKDTISA--
VSGEKLSPSKSPSLSPSPPSPLEKTPLGERSVNFSLTPNEIKVSAEAEVAP-VSPEVTQE
VVEEHCASPEDKTLEVVSPSQSVTGSAGHTPYYQSPTDEKSSHLPTEVIEKPPAVPVSFE
FSD-AKDDSERASVSPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYESFLSADDKTSGR
GAESPFEEKSEKQGSPDQVSPVSEMTSTSLYQDKQEGK-STDFVPIKEDFGQAKKTDDVE
ATSSQPALALDERKLG-DVSPTQIDVSQFGSFKEDTKMSISEGTVSDKSATPVDEGVAED
TYSHMEGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTF
QETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQDHRS-EQSSMSIEFGQESPEHSLAM
DFSRQSPDHPTVGAGVLHITENGPTEVDYSPSDMQDSSLSHKIPALEEP-SYTQDNDLSE
LISVSQVEASPSTSSAHTPSQIASPLQEDTLSDVAPPRDMSLYASLTSEKVQSLEGEKLS
PKSDISPLTPRESSPLYSPTFSDSTSAVKEKTAACHTSS-SPPIDAASAEPYGFRASVLF
DTMQHHLALNRDLATPGLEK---DSGGKTPGDFSYAYQKPEKTTRSPDE-EDYDYESYEK

PF00414 // ENSGT00550000074593_0_Domain_5 (2101, 2117)

TTRTSDVGSYYYEKIERTTKSPSDSGYSYETIGK

PF00414 // ENSGT00550000074593_0_Domain_7 (2135, 2151)

TTKTPEDGDYSYEIIEKTTRTPEEGG
YSYDISEK

PF00414 // ENSGT00550000074593_0_Domain_10 (2169, 2185)

TTSPPEVSGYSYEKTERS-RRLLDDISNGYDDSED

PF00414 // ENSGT00550000074593_0_Domain_12 (2204, 2220)

GGHTLGDPSYSYETTEK
ITS-FPESESYSYETATK

PF00414 // ENSGT00550000074593_0_Domain_14 (2239, 2256)

TTRTPDTS-TYCYETTEKITRTPQASTYSYETS---------
--------DLC---YTAE--------------KKSPSEARQDVDLCLVSSCEYKHPKTEL
SPSFINPNPLEWFASEEPTEESEKPLTQSGGAPPPPGGKQQGRQCDETPPTSVSESAPSQ
TDSDVPPETEECPSITADANIDSEDESETIPTDKTVTYKHMDPPPAPVQDRSPSPRHPDV
SMVDPEALALEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKSDGKSKPLAASPKPAGL
KESSDKVSRVASPKKKESVEKAAKPT-TTPEVK--AARGEEKDKETKNAANASASKSAKT
AT---A-GPGTTKATKSSTVPPGLPVYLDLCYIPNHSNSKNVDVEFFKRVRSSYYVVSGN
DPAAEEPSRAVLDALLEGKAQWGSNMQVTLIPTHDSEVMREWYQETHEKQQDLNIMVLAS
SSTVVMQDESFPACKIEL

------------------------------------------------------------
------------------------------------------------------------
-----MATVVVEATEPEPSGSIANPAASTSPSLSHRFLDSKFYLLVVVGEIVTEEHLRRA
IGNIE-LGIRSWDTNLIECNLDQELKLFVSRHSARFSPEVP-----------GQKILHHR
SDVLETVVLINPSDEAVSTEVRLMITDAARHKLLVLTGQCFENTGELILQSGSFSFQNFI
EIFTDQEIGELLSTTHPANKASLTLFCPEEGDWKNSNLDRHNLQDFINIKLNSASILPEM
EGLSEFTEYLSESVEVPSPFDILEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFNML
INGGSERKSCFWKLIRHLDRVDSILLTHIGDDNLPGINSMLQRKIAELEEEQSQGSTTNS
DWMKNLISPDLGVVFLNVPENLKNPEPNIKMKRSIEEACFTLQYLNKLSMKPEPLFRSVG
NTIDPVILFQKMGVGKLEMYVLNPVKSSKEMQYFMQQW---T-GTN-KDKAE-FILPN-G
QEVD-LPISYL-TSVSS-LIVWHPANPAEKIIRVLFPGNSTQYNILEGLEKLKHLDFLKQ
PLATQKDLTGQVPTPV-VKQTKLKQRADSRESLKPAAKPLPS-KSVRKESKEETPEVTKV
NH-VEKPPKVESKEKVMVKKDK------PIKTETKPSVTEKEVPSK--EEPSPVKAEVAE
K---QATDVKPKAAKEKTVKKETKVKPEDKKEE--KEKPKKEVAKKEDKTPIKKEEKPKK
EEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKEVKKEEKEPKKEIKKLPK
DAKKSSTPLSEAKKPAALKPKVPKKEESVKKDSV-AAGKPKEKGKIKVIKKEGKAAEAVA
A-AV-GTGATTAAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVTKDI
KPQLELIEDEEKLKETEPVEAYVIQKEREVTKGPAESPDEGITTTEGEGECEQTPEELEP
VEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEEHVCVSASKHSPT--
-------ED-EESAKAEADAYI----R-EKRESVASGDDRAEEDMDEAIEKGEAEQSEEE
A--D-EEDKAEDAREEEYEPEK-MEAEDYVMAVVDKAAE-AGGAEEQY-GFLTTPTKQLG
AQSPGREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPM
DEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYSQEYSKPAD---VTPLNGFSEGS
KTDATDGKDYNASASTISPPSSMEEDKFSRSALRDAYCSEVK---ASTTLDIKDSISA--
VSSEKVSPSKSPSLSPSPPSPLEKTPLGERSVNFSLTPNEIKVSAEAEVAP-VSPEVTQE
VVEEHCASPEDKTLEVVSPSQSVTGSAGHTPYYQSPTDEKSSHLPTEVIEKPPAVPVSFE
FSD-AKDENERASVSPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYESFLSADDKASGR
GAESPFEEKSGKQGSPDQVSPVSEMTSTSLYQDKQEGK-STDFAPIKEDFGQEKKTDDVE
AMSSQPALALDERKLG-DVSPTQIDVSQFGSFKEDTKMSISEGTVSDKSATPVDEGVAED
TYSHMEGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTF
QETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQDHRS-EQSSMSIEFGQESPEQSLAM
DFSRQSPDHPTVGAGVLHITENGPTEVDYSPSDMQDSSLSHKIPPMEEP-SYTQDNDLSE
LISVSQVEASPSTSSAHTPSQIASPLQEDTLSDVAPPRDMSLYASLTSEKVQSLEGEKLS
PKSDISPLTPRESSPLYSPTFSDSTSAVKEKTATCHSSS-SPPIDAASAEPYGFRASVLF
DTMQHHLALNRDLSTPGLEK---DSGGKTPGDFSYAYQKPEETTRSPDE-EDYDYESYEK

PF00414 // ENSGT00550000074593_0_Domain_5 (2101, 2117)

TTRTSDVGGYYYEKIERTTKSPSDSGYSYETIGK

PF00414 // ENSGT00550000074593_0_Domain_7 (2135, 2151)

TTKTPEDGDYSYEIIEKTTRTPEEGG
YSYDISEKTTSPPEVSGYSYEKTERS-RRLLDDISNGYDDSEDG

PF00414 // ENSGT00550000074593_0_Domain_12 (2205, 2220)

GHTLGDPSYSYETTEK
ITS-FPESEGYSYETSTK

PF00414 // ENSGT00550000074593_0_Domain_14 (2239, 2256)

TTRTPDTS-TYCYETAE

ENSGT00550000074593_0_Linker_14_15 (2256, 2257)

K

PF00414 // ENSGT00550000074593_0_Domain_15 (2257, 2289)

ITRTPQASTYSYETS---------
--------DLC---YTAE--------------KKSPSEARQDVDLCLVSSCEYKHPKTEL
SPSFINPNPLEWFASEEPTEESEKPLTQSGGAPPPPGGKQQGRQCDETPPTSVSESAPSQ
TDSDVPPETEECPSITADANIDSEDESETIPTDKTVTYKHMDPPPAPVQDRSPSPRHPDV
SMVDPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKSDGKSKPLAASPKPAGL
KESSDKVSRVASPKKKESVEKAAKPT-TTPEVK--AARGEEKDKETKNAANASASKSAKT
AT---A-GPGTTKTTKSSAVPPGLPVYLDLCYIPNHSNSKNVDVEFFKRVRSSYYVVSGN
DPAAEEPSRAVLDALLEGKAQWGSNMQVTLIPTHDSEVMREWYQETHEKQQDLNIMVLAS
SSTVVMQDESFPACKIEL

------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------LRRA
IGNIE-LGIRSWDTNLIECNLDQELKLFVSRHSARFSPEVP-----------GQKILHHR
SDVLETVVLINPSDEAVSTEVRLMITDAARHKLLVLTGQCFENTGELILQSGSFSFQNFI
EIFTDQEIGELLSTTHPANKASLTLFCPEEGDWKNSNLDRHNLQDFINIKLNSASILPEM
EGLSEFTEYLSESVEVPSPFDILEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFNML
INGGSERKSCFWKLIRHLDRVDSILLTHIGDDNLPGINSMLQRKIAELEEERSQGSTSNS
DWMKNLISPDLGVVFLNVPENLKNPEPNIKMKRSIEEACFTLQYLNKLSMKPEPLFRSVG
NTIEPVILFQKMGVGKLEMYVLNPVKSSKEMQYFMQQW---T-GTN-KDKAE-LILPN-G
QEVD-IPISYL-TSVSS-LIVWHPANPAEKIIRVLFPGNSTQYNILEGLEKLKHLDFLKQ
PLATQKDLTGQVPTPT-VKQVKLKQRADSRESLKPATKPLPS-KSVRKESKEEAPEVTKP
SQ-VEKTPKVESKEKVTVKKDK------PIKTETKPSVTEKEVPSK--EEQSPVKAEVAE
K---QATESKPKVTKEKVVKKEIKAKPEEKKEE--KEKPKREVAKKEDKTPLKKDEKPKK
EEVKKEVKKEIKKEEKKELKKEVKKETPLKEAKKEVKKEEKKEVKKEEKEPKKEIKKISK
DIKK-STPVSETKKPAALKPKVAKKEEATKKEPA-AASKLKDKGKVKVIKKEGKTTEAAA
TAVG-TAATTAAAVAAAGIVA-TGPAKELEAERSLMSSPEDLTKDFEELKAEEIDVAKDI
KPQLELIEDEEKLKETESVEAYVIQKETEVLKGSAESPDEGITTTEGEGECEQTPEELEP
VEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEDNVSGSASKHSPT--
--------EDDESAKAEADVHI----K-EKRESVTSGDDRAEEDMDEALEKEEAEQSEEE
G--EE-EDKAEDAREEDYEPEK-LEGEDYVMAVVDKAAE-AGVAEEQY-GFLSTPTKQPG
AQSPGREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPM
DEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYSQEYSKPI----VASFNGLSEGS
KTDATDGKDYNASASTISPPSSMEEDKFSKSALRDAYCSEEKEVKASAALDI----KD--
VSDERLSPTKSPSLSPSPPSPIEKTPLGERSVNFSLTPNEIKVSAEADVTS-VSPGMTQA
VVEEHCASPEEKTLEVVSPSQSVTGSAGHTPYYQSPTDEKASHLPTEATEKPQAVPVSFE
FSEEAKDENERASISPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYEDFLSADGKALGR
GIKSPFEGKNEKQG----ESPVSEVTSTGLYQEEQEGK-STGFIPIREDFGPEKKTNEVE
IMSSQSALALDERKLGGDVSPTQIDVSQFGSFKEDTKMSISEGTVSDKSATPVDEGVAED
TYSHMEGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTF
QETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQDHRS-EQSSMSIEFGQESPEHSLAM
DFSRQSPDHPTVGASMLHITENGPTEVDYSPSDIQDSSLSHKIPPMEEP-SYTQDNDLSE
LISVSQVEASPSTSSAHTPSQIASPLQEDTLSDVVPPRDMSLYASLTSEKAQSLEGEKLS
PKSDISPLTPRESSPLYSPGFSDSTSATTENAAGR-QTS-SPPMDAASAEPYGFRASMLF
DTMQHHLALNRDLTTSSVEK---DSGGKTPGDFNYAYEKPEKTTRSPDE-EDYDYESYEK
TSRAPDTDGYYYEKTER

PF00414 // ENSGT00550000074593_0_Domain_6 (2118, 2134)

TIKSPCDSGYSYETIEKTIKPQEDGGYACEITEK

PF00414 // ENSGT00550000074593_0_Domain_9 (2152, 2168)

TTRTPEEGG
YSYEISE

ENSGT00550000074593_0_Linker_9_10 (2168, 2169)

K

PF00414 // ENSGT00550000074593_0_Domain_10 (2169, 2185)

TTRTPEVGGYTYEKTERS-RRLLDDISNGYDDSEDGGHTLADCSYSYETTEK
ISS-FPESESYSYEMSTK

PF00414 // ENSGT00550000074593_0_Domain_14 (2239, 2256)

TTRSPDTA-TYCYETME

ENSGT00550000074593_0_Linker_14_15 (2256, 2257)

K

PF00414 // ENSGT00550000074593_0_Domain_15 (2257, 2290)

ITKTPQASTYSYETS---------
--------DRC---YTPE--------------KRSPSEARQDVDLCLVSSCEYKHPKTEL
SPSFINPNPLEWFASEESTEDSEKPLAESGGAPPPSGGKQQGRQCDETPPTSVSESAPSQ
TDSDVPPETEECPSITADANIDSEDESETIPTDKTVTYKHMDPPPAPMQDRSPSPRHPDV
SMVDPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKADGKSKPLAASPKPGAL
KESSDKVSRVASPKKKESVEKATKTT-TTPEIK--ATRGDEKDKETKNAANASASKSAKT
ATA----GPGTTKTAKSSTVPPGLPVYLDLCYIPNHSNSKNVDVEFFKRVRSSYYVVSGN
DPAAEEPSRAVLDALLEGKAQWGSNMQVTLIPTHDSEVMREWYQETHEKQQDLNIMVLAS
SSTVVMQDESFPACKIEL

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------MITDAARHKLLVLTGQCFENTGELILQSGSFSFQNFI
EIFTDQEIGELLSTTHPANKASLTLFCPEEGDWKNSNLDRHNLQDFINIKLNSASILPEM
EGLSEFTEYLSESVEVPSPFDILEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFNML
INGGSERKSCFWKLIRHLDRVDSILLTHIGDDNLPGINSMLQRKIAELEEEQSQGSTTNS
DWMKNLISPDLGVVFLNVPENLKNPEPNIKMKRSIEEACFTLQYLNKLSMRPEPLFRSVG
NTIDPVILFQKMGVGKLEMYVLNPVKSSKEMQYFMQQW---T-GTN-KDKAE-LILPN-G
QEVD-LPISYL-TSVSS-LIVWHPANPAEKIIRVLFPGNSTQYNILEGLEKLKHLDFLKQ
PLATQKDLTGQVPTPV-VKQTKLKQRADSRESLKPATKPLPS-KSVRKESKEETPEVAKV
NH-VEKPPKVESKEKVTVKKDK------PVKTETKPSVTEKEVPSK--EEPSPVKAEVAE
K---QATDVKPKAAKEKTVKKETKAKPEDKKEE--KEKPKKEVAKKEDKTPIKKEEKPKK
EEVKKEVKKEIKKEEKKEPKKEVKKETPLKEAKKEVKKEEKKEVKKEEKEPKKEIKKLPK
DAKKSSTPLSEAKKPAALKPKVPKKEEPVKKDSV-ATGKPKEKGKIKVIKKEGKATEAVA
A-AV-GTGAATAAVVAAAGIAATGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVTKDI
KPQLELIEDEEKLKETEPVEAYVIQKETEVTKGPAESPDEGITTTEGEGECEQTPEELEP
VEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEEHICVSASKHSPT--
-------E-YEESAKAEADAYI----R-EKRESVASGDDRAEEDMDEAIEKGEAEQSEEE
A--D-EEDKAEDAREEEYEPEK-MEAEDYVMAVVDKAAE-AGGAEEQY-GFLTTPTKQPG
AQSPGREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPM
DEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYSQEYSKPAD---VTPLNGFSEGS
KTDATDGKDYNASASTISPPSSMEEDKFSRSALRDAYCSEVK---ASTTLDIKDTISA--
VSGGKLSPSKSPSLSPSPPSPLEKTPLGERSVNFSLTPNEIKVSAEAEVAP-VSPEVTQE
VVEEHCASPEDKTLEVVSPSQSVTGSAGHTPYYQSPTDEKSSHLPTEVIEKPPAVPVSFE
ISD-AKDDSERASVSPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYESFLSADDKASGR
GAESPFEEKSEKQSSPDQVSPVSEMTSTSLYQDKQEGK-STDFVPIKEDFGQEKKTDDVE
ATSSQPALALDERKLG-DVSPTQIDVSQFGSFKEDTKMSISEGTVSDKSATPVDEGVAED
TYSHMEGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTF
QETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQDHRS-EQSSMSIEFGQESPEHSLAM
DFSRQSPDHPTVGAGVLHITENGPTEVDYSPSDMQDSSLSHKIPPMEEP-SYTQDNDLSE
LISVSQVEASPSTSSAHTPSQIASPLQEDTLSDVAPPRDMSLYASLTSEKVQSLEGEKLS
PKSDISPLTPRESSPLYSPTFSDSTSAVKEKTAACHTSS-SPPIDAASAEPYGFRASVLF
DTMQHHLALSRDLATPGLEK---DSGGKTPGDFSYAYQKPEKTTRSPDE-EDYDYESYEK

PF00414 // ENSGT00550000074593_0_Domain_5 (2101, 2117)

TTRTSDVGGYYYEKIERTTKSPSDSGYSYETIGK

PF00414 // ENSGT00550000074593_0_Domain_7 (2135, 2151)

TTKTPEDGDYSYEIIEKTTRTPEEGG
YSYDISEKTTSPPEVSGYSYEKTERS-RRLLDDISNGYDDSEDG

PF00414 // ENSGT00550000074593_0_Domain_12 (2205, 2220)

GHTLGDPSYSYETTEK
ITS-FPESESYSYETATK

PF00414 // ENSGT00550000074593_0_Domain_14 (2239, 2256)

TTRTPDTS-TYCYETTE

ENSGT00550000074593_0_Linker_14_15 (2256, 2257)

K

PF00414 // ENSGT00550000074593_0_Domain_15 (2257, 2289)

ITRTPQASTYSYETS---------
--------DLC---YTAE--------------KKSPSEARQDVDLCLVSSCEYKHPKTEL
SPSFINPNPLEWFASEEPTEESEKPLTQSGGAPPPPGGKQQGRQCDETPPTSVSESAPSQ
TDSDVPPETEECPSITADANIDSEDESETIPTDKTVTYKHIDPPPAPVQDRSPSPRHPDV
SMVDPEALALEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKSDGKSKPLAASPKPAGL
KESSDKVSRVASPKKKESVEKAAKPT-TTPEVK--AARGEEKDKETKNAANASASKSAKT
AT---A-GPGTTKATKSSTVPPGLPVYLDLCYIPNHSNSKNVDVEFFKRVRSSYYVVSGN
DPAAEEPSRAVLDALLEGKAQWGSNMQVTLIPTHDSEVMREWYQETHEKQQDLNIMVLAS
SSTVVMQDESFPACKIEL

------------------------------------------------------------
------------------------------------------------------------
-----MATVVVEATEPEPSGSIANPAASTSPSLSHRFLDSKFYLLVVVGEIVTEEHLRRA
IGNIE-LGIRSWDTNLIECNLDQELKLFVSRHSARFSPEVP-----------GQKILHHR
SDVLETVVLINPSDEAVSTEVRLMITDAARHKLLVLTGQCFENTGELILQSGSFSFQNFI
EIFTDQEIGELLSTTHPANKASLTLFCPEEGDWKNSNLDRHNLQDFINIKLNSASILPEM
EGLSEFTEYLSESVEVPSPFDILEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFNML
INGGSERKSCFWKLIRHLDRVDSILLTHIGDDNLPGINSMLQRKIAELEEEQSQGSTTNS
DWMKNLISPDLGVVFLNVPENLKNPEPNIKMKRSIEEACFTLQYLNKLSMRPEPLFRSVG
NTIDPVILFQKMGVGKLEMYVLNPVKSSKEMQYFMQQW---T-GTN-KDKAE-LILPN-G
QEVD-LPISYL-TSVSS-LIVWHPANPAEKIIRVLFPGNSTQYNILEGLEKLKHLDFLKQ
PLATQKDLTGQVPTPV-VKQTKLKQRADSRESLKPATKPLPS-KSVRKESKEETPEVTKV
NH-VEKPPKVESKEKVTVKKDK------PVKTETKPSVTEKEVPSK--EEPSPVKAEVAE
K---QATDVKPKAAKEKTVKKETKAKPEDKKEE--KEKPKKEVAKKEDKTPIKKEEKPKK
EEVKKEVKKEIKKEEKKEPKKEVKKETPLKEAKKEVKKEEKKEVKKEEKEPKKEIKKLPK
DAKKSSTPLPEAKKPAALKPKVPKKEEPVKKDSV-AAGKPKEKGKIKVIKKEGKATEAVA
A-AV-GTGAATAAVVAAAGIAATGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVTKDI
KPQLELIEDEEKLKETEPVEAYVIQKETEVTKGPAESPDEGITTTEGEGECEQTPEELEP
VEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEEHICVSASKHSPT--
-------E-YEESAKAEADAYI----R-EKRESVASGDDRAEEDMDEAIEKGEAEQSEEE
A--D-EEDKAEDAREEEYEPEK-MEAEDYVMAVVDKAAE-AGGAEEQY-GFLTTPTKQPG
AQSPGREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPM
DEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYSQEYSKPAD---VTPLNGFSEGS
KTDATDGKDYNASASTISPPSSMEEDKFSRSALRDAYCSEVK---ASTTLDIKDTISA--
VSGERLSPSKSPSLSPSPPSPLEKTPLGERSVNFSLTPNEIKVSAEAEVAP-VSPEVTQE
VVEEHCASPEDKTLEVVSPSQSVTGSAGHTPYYQSPTDEKSSHLPTEVIEKPPTVPVSFE
FSD-AKDDSERASVSPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYESFLSADDKASGR
GAESPFEEKSEKQSSPDQVSPVSEMTSTSLYQDKQEGK-STDFVPIKEDFGQEKKTDDVE
ATSSQPALALDERKLG-DVSPTQIDVSQFGSFKEDTKMSISEGTVSDKSATPVDEGVAED
TYSHMEGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTF
QETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQDHRS-EQSSMSIEFGQESPEHSLAM
DFSRQSPDHPTVGAGVLHITENGPTEVDYSPSDMQDSSLSHKIPPMEEP-SYTQDNDLSE
LISVSQVEASPSTSSAHTPSQIASPLQEDTLSDVAPPRDMSLYASLTSEKVQSLEGEKLS
PKSDISPLTPRESSPLYSPTFSDSTSAVKEKTAACHTSS-SPPIDAASAEPYGFRASVLF
DTMQHHLALNRDLATPGLEK---DSGGKTPGDFSYAYQKPEKTTRSPDE-EDYDYESYEK

PF00414 // ENSGT00550000074593_0_Domain_5 (2101, 2117)

TTRTSDVGGYYYEKIERTTKSPSDSGYSYETIGK

PF00414 // ENSGT00550000074593_0_Domain_7 (2135, 2151)

TTKTPEDGDYSYEIIEKTTRTPEEGG
YSYDISEKTTSPPEVSGYSYEKTERS-RRLLDDISNGYDDSEDG

PF00414 // ENSGT00550000074593_0_Domain_12 (2205, 2220)

GHTLGDPSYSYETTEK
ITS-FPESESYSYETATK

PF00414 // ENSGT00550000074593_0_Domain_14 (2239, 2256)

TTRTPDTS-TYCYETTE

ENSGT00550000074593_0_Linker_14_15 (2256, 2257)

K

PF00414 // ENSGT00550000074593_0_Domain_15 (2257, 2289)

ITRTPQASTYSYETS---------
--------DLC---YTAE--------------KKSPSEARQDVDLCLVSSCEYKHPKTEL
SPSFINPNPLEWFASEEPTEESEKPLTQSGGAPPPPGGKQQGRQCDETPPTSVSESAPSQ
TDSDVPPETEECPSITADANIDSEDESETIPTDKTVTYKHMDPPPAPVQDRSPSPRHPDV
SMVDPEALALEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKSDGKSKPLAASPKPAGL
KESSDKVSRVASPKKKESVEKAAKPT-TTPEVK--AARGEEKDKETKNAANASASKSAKT
AT---A-GPGTTKATKSSTVPPGLPVYLDLCYIPNHSNSKNVDVEFFKRVRSSYYVVSGN
DPAAEEPSRAVLDALLEGKAQWGSNMQVTLIPTHDSEVMREWYQETHEKQQDLNIMVLAS
SSTVVMQDESFPACKIEL

------------------------------------------------------------
------------------------------------------------------------
-----MATVVVEATEPEPSGSIGNPAASTSPSLSHRFLDSKFYLLVVVGETVTEEHLRRA
IGNIE-LGIRSWDTNLIECNLDQELKLFVSRHSARFSPEVP-----------GQKILHHR
SDVLETVVLINPSDEAVSTEVRLMITDAARHKLLVLTGQCFENTGELILQSGSFSFQNFI
EIFTDQEIGELLSTTHPANKASLTLFCPEEGDWKNSNLDRHNLQDFINIKLNSASILPEM
EGLSEFTEYLSESVEVPSPFDILEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFNML
INGGSERKSCFWKLIRHLDRVDSILLTHIGDDNLPGINSMLQRKIAELEEERSQGSTSNS
DWMKNLISPDLGVVFLNVPENLKDPEPNIKMKRSIEEACFTLQYLNKLSMKPEPLFRSVG
NTIEPVILFQKMGVGKLEMYVLNPVKSSKEMQYFMQQW---T-GTN-KDKAE-LILPN-G
QEVD-IPISYL-TSVSS-LIVWHPANPAEKIIRVLFPGNSTQYNILEGLEKLKHLDFLKQ
PLATQKDLTGQVPTPP-VKQVKLKQRADSRESLKPATKPVAS-KSVRKESKEETPEVTKT
SQ-VEKTPKVESKEKVLVKKDK------PVKTESKPSVTEKEVSSK--EEQSPVKAEVAE
K---QATESKPKVTKDKVVKKEIKTKLEEKKE----EKPKKEVVKKEDKTPLKKDEKPRK
EEVKKEIKKEIKKEERKELKKEVKKETPLKDAKKEVKKEEKKEVKKEEKEPKKEIKKISK
DIKK-STPLSDTKKPSALKPKVAKKEESTKKEPL-AAGKLKDKGKVKVIKKEGKTTEAAA
TAVG-TAATTAAVVAAAGIAA-SGPVKELEAERSLMSSPEDLTKDFEELKAEEIDVAKDI
KPQLELIEDEEKLKETQPGEAYVIQKETEVSKGSAESPDEGITTTEGEGECEQTPEELEP
VEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEDNASGSASKHSPT--
--------EDDESAKAEADVHL----K-EKRESVVSGDDRAEEDMDDVLEKGEAEQSEEE
G--EE-EDKAEDAREEGYEPDK-TEAEDYVMAVADKAAE-AGVTEEQY-GYLGTSAKQPG
IQSPSREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPM
DEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYSQEYSKPA----VASFNGLSEGS
KTDATDGKDYNASASTISPPSSMEEDKFSKSALRDAYCSEEKELKASAELDI----KD--
VSDERLSPAKSPSLSPSPPSPIEKTPLGERSVNFSLTPNEIKVSAEGEARS-VSPGVTQA
VVEEHCASPEEKTLEVVSPSQSVTGSAGHTPYYQSPTDEKSSHLPTEVTEKPQAVPVSFE
FSE-AKDENERASLSPMDEPVPDSESPVEKVLSPLRSPPLLGSESPYEDFLSADSKVLGR
RSESPFEGKNGKQGFPDRESPVSDLTSTGLYQDKQEEK-STGFIPIKEDFGPEKKTSDVE
TMSSQSALALDERKLGGDVSPTQIDVSQFGSFKEDTKMSISEGTVSDKSATPVDEGVAED
TYSHMEGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTF
QETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQDHRS-EQSSMSIEFGQESPEHSLAM
DFSRQSPDHPTLGASVLHITENGPTEVDYSPSDIQDSSLSHKIPPTEEP-SYTQDNDLSE
LISVSQVEASPSTSSAHTPSQIASPLQEDTLSDVVPPREMSLYASLASEKVQSLEGEKLS
PKSDISPLTPRESSPLYSPGFSDSTSAAKETAAAHQASS-SPPIDAATAEPYGFRSSMLF
DTMQHHLALNRDLTTSSVEK---DSGGKTPGDFNYAYQKPENAAGSPDE-EDYDYESQEK

PF00414 // ENSGT00550000074593_0_Domain_5 (2101, 2117)

TIRTHDVGGYYYEKTE

ENSGT00550000074593_0_Linker_5_6 (2117, 2118)

R

PF00414 // ENSGT00550000074593_0_Domain_6 (2118, 2134)

TIKSPCDSGYSYETIEKTIKTPEDGGYTCEITEK

PF00414 // ENSGT00550000074593_0_Domain_9 (2152, 2168)

TTRTPEEGG
YSYEISE

ENSGT00550000074593_0_Linker_9_10 (2168, 2169)

K

PF00414 // ENSGT00550000074593_0_Domain_10 (2169, 2185)

TTRTPEVSGYTYEKTERS-RRLLDDISNGYDDTEDGGHTLGDCSYSYETTEK
ITS-FPESESYSYETSTK

PF00414 // ENSGT00550000074593_0_Domain_14 (2239, 2256)

TTRSPDTS-AYCYETME

ENSGT00550000074593_0_Linker_14_15 (2256, 2257)

K

PF00414 // ENSGT00550000074593_0_Domain_15 (2257, 2290)

ITKTPQASTYSYETS---------
--------DRC---YTTE--------------KKSPSEARQDVDLCLVSSCEFKHPKTEL
SPSFINPNPLEWFAGEEPTEESEKPLTQSGGAPPPSGGKQQGRQCDETPPTSVSESAPSQ
TDSDVPPETEECPSITADANIDSEDESETIPTDKTVTYKHMDPPPAPMQDRSPSPRHPDV
SMVDPDALAVDQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKGDGKSKPLAASPKPGAL
KESSDKVSRVASPKKKESVEKATKTT-TTPEVK--ATRGEEKDKETKNAANASASKSAKT
ATA----GPGTTKTAKSSTVPPGLPVYLDLCYIPNHSNSKNVDVEFFKRVRSSYYVVSGN
DPAAEEPSRAVLDALLEGKAQWGSNMQVTLIPTHDSEVMREWYQETHEKQQDLNIMVLAS
SSTVVMQDESFPACKIEL

------------------------------------------------------------
------------------------------------------------------------
-----MATVVVEATEPEPSGGIANPAASTSPSLSHRFLDSKFYLLVVVGEIVTEEHLRRA
IGNIE-FXXXXXXXXXXXXXXXXXXX-----------XXXXXXXXXXXXXXXXQKILHHR
SDVLETVVLINPSDEAVSTEVRLLITDAARHKLLVLTGQCFENTGELILQSGSFSFQNFI
EIFTDQEIGELLSTTHPANKASLTLFCPEEGDWKNSNLDRHNLQDFINIKLNSASILPEM
EGLSEFTEYLSESVEVLSPFDILEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFNML
INGGSERKSCFWKLIRHLDRVDSILLTHIGDDNLPGINSMLQRKIAELEEEQSQGSTTNS
DWMKNLISPDLGVVFLNVPENLKNPEPNIKMKRSLEEACFTLQYLNKLSMKPEPLFRSVG
NTIDPVILFQKMGVGKLEMYVLNPVKSSKEMQYFMQQW---T-GTS-KDKAE-LILPN-G
QEVD-IPIPYL-TSVSS-LIVWHPANPAEKIIRVLFPGNSTQYNILEGLEKLKHLDFLKQ
PLATQKDLTGQVPAPA-VKQVKLKQRADSKENLKPAAKPVPS-KPVRKESKEEAPDVTKT
NQ-VEKPAKVESKEKAPVKKDK------PLKAEAKPAVAEKEAPSK--DEQPPVKADVAE
K---QATDVKPKVSKEKTVKKEVKAKSDEKKEE--KEKTKKEVVKKEDKTPVKKEEKPKK
EEAKKEIKKEIKKEEKKEPKKEVKKETPLKEAKKEVKKEEKKEMKKEEKEPKKEIKKLTK
DTKKPSTPLSDAKKPAALKPKVAAKKEEPAKKDTVAAGKPKEKGKIKVVKKESKPTEVVA
ATAT----AAAMAAVAAAGTAAPSPGKEL

PF00183 // ENSGT00550000074593_0_Domain_1 (990, 1015)

EAERSLMSSPEDLTKDFEELKAEEV

ENSGT00550000074593_0_Linker_1_2 (1015, 1490)

DVAKXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXEEPEEDAEESLGVGAPKHGAA--
-------E-DEEVAKAEADVHI----K-EKRESVASADDRAEEDMDEAIEKEEAEQSEEE
G---NEEDKAEDAREEDYEPEK-AEAEDYMMAVVDKAAE-TGGAEDQY-GFLTASVKQPG
AQSPSREPASSIHDETLPGGSESEATASDEDNREDQPEEFTATSGYTQSTIEISSEPTPM
DEMSTPRDVMSDETNNEETESPSQEFVNITKYESALYSQEYAKPA----VTSLNGLSDGS
KTDATEGKDYNASASTISPPSSMEEDKFSRSALRDAYYLEEKEAKASAKLEVKETFST--
VSEEKLSPPKSPSQSPSPQSPIEKTPLGERSVNFSLTPNEIQVSTEAEV

PF02818 // ENSGT00550000074593_0_Domain_2 (1490, 1516)

AP-VSPEVPQE
VVEERCASPEEKTLEVVSPSQSVTGSAGHTPYYQSPTEEKSSHLPTEVIEKPPAVPVRFE
FSD-AKDESDRASVSPMDEPVPDSESPLEKVLSPLRSPPLLGSESAYDSFLSVDDKAPSR
SSESPFEGKDGKQELPDQMSPVSDMTSMSLYPDREEGK-STDFIPIKEDFDQDKKTDDVE
SASSQPALALDERKLG-DVSPTQVDVSQFGSFKEDTKMSISEGTVSDKSATPVDEGVAED
TYSHMEGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTF
QETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQDHRS-EQSSMSIEFGQESPEHSLAM
DFSRQSPDQSAAGAGVLHITENGPTEVDYSPSDMQDSSLSHKIPPMEEP-SFTQDNDLSE
LISVSQVEASPSTSSAHTPSQIASPLQEDTLSDVAAPRDIALYASLTSDKVQSLEGEKLS
PKSDISPLTPRESSPLYSPSFSDSTSAVKESMAACPTSS-SPPTGAGSAEPYGFRASMLF
DTMQHHLALSRDLTTSGVEK---DSGGKTPGDFSYAYQTPEK

PF00414 // ENSGT00550000074593_0_Domain_4 (2083, 2100)

ATRSPDE-EDYDYESYE

ENSGT00550000074593_0_Linker_4_5 (2100, 2101)

K

PF00414 // ENSGT00550000074593_0_Domain_5 (2101, 2117)

TTRAPDMDSYYYEKAE

ENSGT00550000074593_0_Linker_5_6 (2117, 2118)

R

PF00414 // ENSGT00550000074593_0_Domain_6 (2118, 2134)

TIKSPCDGGYSYETIE

ENSGT00550000074593_0_Linker_6_7 (2134, 2135)

K

PF00414 // ENSGT00550000074593_0_Domain_7 (2135, 2151)

TTKSPEDGGSACEITE

ENSGT00550000074593_0_Linker_7_9 (2151, 2152)

K

PF00414 // ENSGT00550000074593_0_Domain_9 (2152, 2168)

TTRTPAEDG
YSYEMSE

ENSGT00550000074593_0_Linker_9_10 (2168, 2169)

K

PF00414 // ENSGT00550000074593_0_Domain_10 (2169, 2185)

TTRTPAVSGYSYEKTERS-RRLLDDISNGYDDSDD

PF00414 // ENSGT00550000074593_0_Domain_12 (2204, 2220)

GSHTLGDSSYSYETTEK
ISS-FPESESYSYETSTK

PF00414 // ENSGT00550000074593_0_Domain_14 (2239, 2256)

TTHTPDTS-TYCYETSE

ENSGT00550000074593_0_Linker_14_15 (2256, 2257)

K

PF00414 // ENSGT00550000074593_0_Domain_15 (2257, 2290)

ITKTPQGSTYSYETS---------
--------DRC---YAAE---------------KSPSEARQEVDLCLVSSCEYKHPKTEL
SPSFINPNPLEWFASEDPTDDTEKPLTQLGGAPPPPGGKVQGRQCDETPPTSVSESAPSQ
TDSDVPPETEECPSITADANIDSEDESETIPTDKTVTYKHMDPPPAPVQDRSPSPRHPDV
SMVDPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKSDGKSKPAAASPKPATL
KESSDKVSRVASPKKKESAEKVTKTS-TTPEVK--AARGDEKDKETKNAANVSASKSSKT
ATA----GPGTTKTAKPSAVPPGLPVYLDLCYIPNHSNSKNVDVEFFKRVRSSYYVVSGN
DPAAEEPSRAVLDALLEGKAQWGSNMQVTLIPTHDSEVMREWYQETHEKHQDLNIMVLVS
SSTEVMQDESFPAK-IEL

------------------------------------------------------------
------------------------------------------------------------
-----MATVVVEATEPEPSGSIANPAATTSPSLSHRFLDSKFYLLVVVGEIVTEEHLRRA
IGNIE-LGIRSWDTNLIECNLDQELKLFVSRHSARFSPEVP-----------XXXXXXXX
XXXXXXXXXXXXXXXXXXXXVRLMITDAARHKLLVLTGQCFENTGELILQSGSFSFQNFI
EIFTDQEIGELLSTTHPANKASLTLFCPEEGDWKNSNLDRHNLQDFINIKLNSASILPEM
EGLSEFTEYLSESVEVPSPFDILEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFNML
INGGSERKSCFWKLIRHLDRVDSILLTHIGDDNLPGINSMLQRKIAELEEEQSQGSTTNS
DWMKNLISPDLGVVFLNVPENLKNPEPNIKMKRSIEEACFTLQYLNKLSMRPEPLFRSVG
NTIEPVILFQKMGVGKLEMYVLNPVKSSKEMQYFMQQW---T-GTN-KDKAE-LILPN-G
QEID-IPISYL-TSVSS-LIVWHPANPAEKIIRVLFPGNSTQYSILEGLEKLKHLDFLKQ
PLATQKELTGQVATPA-MKQVKLKQRADSRESLKPAAKPLPS-KSVRKESKEETAEVTKA
NH-VEKPPKVESKEKVTVKKDK------PVKTETKPPVAEG-VPSK--EELPSQAXXXXX
X---XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX---XX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXKGEKGPKSDRKLLN-
---TKPSTVPEAKN--PALPKVPKKEEFVKKDSV-AAGKPKEKGKIKVVKKEGKAAEAAA
VASV-------AAVAAAAGMATTGPAKDLEAERSLMSSPEDLTKDFEELKAEEVDVSKDI
KPQLELIEDEEKLKETEPVEAYVIQKETEVIKGPAESPDEGITTTEGEGECEQTPEELEP
VEKQGVEDTEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDAEENVCESTSKHSPV--
-------EE-EESAKAEADVHI----R-EKRASVASGDDRAEEDMDEALEKGEAELSEEE
G--D-EEDKAEDAREEDYEPEK-AEAEDYVMAVVDKAAE-AGGAEDQY-GFLTTSSKQLG
AQSPVQEPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPM
DEMSTPRDVMSDETNNEETESPSQEFVNITKYESALYSQEYPKP-A---VTSLNGLSEES
KTDATDGKDYNASASTISPPSSMEEDKFSRSALRDAYYSEEKDVRASATLEIKDMVSA--
VADEKLSPPKSPSLSPSPPSPIEKTPLGERSVNFSLTPNEIQVSAEAEVVP-VSPEVTQE
VVEEPCASPEDKTLEVVSPSQSVTGSAGHTPYYQSPTEEKSSHLPTEVTEKPPAAPVSFE
FSD-AKDESERASISPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYESFLSVDDQAPGR
CTESPFEGKNGKQGFPDQISPVSDMTSTGVFQDKQEGK-STDFIPIKEDFGPERKTDDVE
AMSSQSGLALDERKLG-DVSPTQIDVSQFGSFKEDTKMSISEGIXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXX---XXXXXXXGDFSYAYQKPEK

PF00414 // ENSGT00550000074593_0_Domain_4 (2083, 2100)

TIRSPDE-EGYDYESYE

ENSGT00550000074593_0_Linker_4_5 (2100, 2101)

K

PF00414 // ENSGT00550000074593_0_Domain_5 (2101, 2117)

TTRTPDVSGYYYEKTE

ENSGT00550000074593_0_Linker_5_6 (2117, 2118)

G

PF00414 // ENSGT00550000074593_0_Domain_6 (2118, 2134)

TTKSPCDSGYSYETIE

ENSGT00550000074593_0_Linker_6_7 (2134, 2135)

K

PF00414 // ENSGT00550000074593_0_Domain_7 (2135, 2151)

TTKTPEDGGYAYEITE

ENSGT00550000074593_0_Linker_7_9 (2151, 2152)

K

PF00414 // ENSGT00550000074593_0_Domain_9 (2152, 2168)

TTQSPEESG
YSFEIHE

ENSGT00550000074593_0_Linker_9_10 (2168, 2169)

K

PF00414 // ENSGT00550000074593_0_Domain_10 (2169, 2185)

TIRTPEVSGYSYEKTERS-RRLLDDISNGYDDSEE

PF00414 // ENSGT00550000074593_0_Domain_12 (2204, 2220)

GGHIPGDSSYSYETTEK
TAS-FPESESYSYATSTT

PF00414 // ENSGT00550000074593_0_Domain_14 (2239, 2256)

ATRTPDTS-AYCYETTE

ENSGT00550000074593_0_Linker_14_15 (2256, 2257)

K

PF00414 // ENSGT00550000074593_0_Domain_15 (2257, 2290)

IARTPQASPYSYETS---------
--------DQC---YSAE--------------KKSPSEARQDVDLCLVSSCEYKHPKTEL
SPSFINPNPLEWFASEEPTEESEKPLTQSGGVPPPPGGKPQGRQCDETPPTSVSESAPSQ
TDSDVPPETEECPSITADANIDSEDESETIPTDKTVTYKHMDPPPAPMDR---SPSHPDV
SMMDP-ALGIEQNLGKAXXXXLKEKTKPKNPGTKTKSSSPFKKGDGKSKPSAASPKPGAL
KESSDKVSRVASPKKKDSVEKATKTT-TNPEVK--APRGEEKDKETKNAANASTSKSVKT
AT---A-GPGTAKMSKPSAVPPGPPVYLDLCYIPNHSNSKNVDVEFFKRVRSSYYVVSGN
DPAAEEPSRAVLDALLEGKAQWFINMQVTLIPTHDSEVMREWYQETHEKQQDLNIMVLAS
SSTVVMQDESFPACKIEL

------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------KNGSSKRTE
WLTVE-LNMSKWGTNLATGFYNYPTTL---------------------------------
------------------------INDNHLHLFFLFF-SFFLSFS--FFLSFSLSLSLFL
S-FFLSQIGELLSTTHPANKASLTLFCPEEGDWKNSNLDRHNLQDFINIKLNSASILPEM
EGLSEFTEYLSESVEVPSPFDILEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFNML
INGGSERKSCFWKLIRHLDRVDSILLTHIGDDNLPGINSMLQRKIAELEEEQSQGSTTNS
DWMKNLISPDLGVVFLNVPENLKNPEPNIKMKRSIEEACFTLQYLNKLSMKPEPLFRSVG
NTIDPVILFQKMGVGKLEMYVLNPVKSSKEMQYFMQQW---T-GTN-KDKAE-LILPN-G
QEVD-LPISYL-TSVSS-LIVWHPANPAEKIIRVLFPGNSTQYNILEGLEKLKHLDFLKQ
PLATQKDLTGQVPTPV-VKQTKLKQRADSRESLKPAAKPLPS-KSVRKESKEETPEVTKV
NH-VEKPPKVESKEKVTVKKDK------PVKTETKPSVTEKEVPSK--EEPSPVKAEVAE
K---QATDVKPKAAKEKTVKKETKVKPEDKKEE--KEKPKKEVAKKEDKTPIKKEEKPKK
EEVKKEVKKEIKKEEKKEPKKEVKKETPLKEVKKEVKKEEKKEVKKEEKEPKKEIKKLPK
DAKKSSTPLSEAKKPAALKPKVPKKEESVKKDSV-AAGKPKEKGKIKVIKKEGKATEAVA
A-AV-GTGATTAAMV--AGLAATGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVTKDI
KPQLELIEDEEKLKETEPVEAYVIQKETEVTKGPAESPDEGITTTEGEGECEQTPEELEP
VEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEEHVCVSTSKHSPA--
-------ED-EESAKAEADAYI----R-EKRESVASGDDRAEEDMDEAIEKGEAEQSEEE
A--D-EEDKAEDAREEEYEPEK-MEAEDYVMAVVDKAAE-AGGAEEQY-GFLTTPTKQPG
AQSPGREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPM
DEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYSQEYSKPAD---VTQLNGLSEGS
KTDATDGKDYNASASTISPPSSMEEDKFSRSALRDAYCSEVKA---STTLDIKDTISA--
VSGEKVSPSKSPSLSPSPPSPLEKTPLGERSVNFSLTPNEIKVSAEAEVAP-VSPEVTQE
VVEEHCASPEDKTLEVVSPSQSVTGSAGHTPYYQSPTDEKSSHLPTEVIEKPPAVPVSFE
FSD-AKDENERASVSPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYESFLSADDKASGR
GAESPFEEKSGKQGSPDQVSPVSEMTSTSLYEDKQEGK-STDFVPIKEDFGQEKKTDDVE
AMSSQPALALDERKLG-DVSPTQIDVSQFGSFKEDTKMSISEGTVSDKSATPVDEGVAED
TYSHMEGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTF
QETEMSPSKEECPRPMSISPPDFSPKTAKSRTPIQDHRS-EQSSMSIEFGQESPEQSLAM
DFSRQSPDHPTVGAGVLHITENGPTEVDYSPSDMQDSSLSHKIPPVEEP-SYTQDNDLSE
LISVSQVEASPSTSSAHTPSQIASPLQEDTLSDVAPPRDMSLYASLTSEKVQSLEGEKLS
PKSDISPLTPRGSSPLYSPTFSDSTSAVKEKTAACHTSS-SPPIDAASTEPYGFRASVLF
DTMQHHLALNRDLATPGLEK---DSGGKTPGDFSYAYQKPEETTRSPDE-EDYDYESYEK
TSRTSDVGSYYYEKIERTTKSPSDSGYSYETIGK

PF00414 // ENSGT00550000074593_0_Domain_7 (2135, 2151)

TTKTPEDGDYSYEIIEKTTRTPEEGG
YSYDVSEKTTSPPEVSGYSYEKTERS-RRLLDDISNGYDDSEDG

PF00414 // ENSGT00550000074593_0_Domain_12 (2205, 2220)

GHTLGDPSYSYETTEK
ITS-FPESEGYSYETSTKTTPTPDTS-TYCYETAEKITRTPQASTYSYQTS---------
--------DLC---YTAE--------------KKSPSEARQDVDLCLVSSCEYKHPKTEL
SPSFINPNPLEWFASEEPTEESEKPLTQSGGAPPPPGGKQQGRQCDETPPTSVSESAPSQ
TDSDVPPETEECPSITADANIDSEDESETIPTDKTVTYKHMDPPPAPMQDRSPSPRHPDV
SMVDPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKSDGKSKPLAASPKPGGL
KESSDKVSRVASPKKKESVEKAAKPT-TTPEVK--AARGEEKDKETKNAANASASKSAKT
AT---A-GPGTTKTTKSSAVPPGLPVYLDLCYIPNHSNSKNVDVEFFKRVRSSYYVVSGN
DPAAEEPSRAVLDALLEGKAQWGSNMQVTLIPTHDSEVMREWYQETHEKQQDLNIMVLAS
SSTVVMQDESFPACKIEL

------------------------------------------------------------
------------------------------------------------------------
-----MATVVVEASEPEPSGSIANPAASTSPSLSHRFLDSKFYLLVVVGEVVTEEHLRRA
IGNIE-LGIRSWDTNLIECNLDQELKLFVSRHSARFSPEVP-----------GQKILHHR
SDVLETVVLINPSDEAVSTEVRLMITDAARHKLLVLTGQCFENTGELILQAGSFSFQNFI
EIFTDQEIGELLSTTHPANKASLTLFCPEEGDWKNSNLDRHNLQDFINIKLNSASILPEM
EGLSEFTEYLSESVEVPSPFDILEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFNML
INGGSERKSCFWKLIRHLDRVDSILLTHIGDDNLPGINSMLQRKIAELEEEQSQGSTTNS
DWMKNLISPDLGVVFLNVPENLKNPEPNIKMKRSIEEACFTLQYLNKLSMKPEPLFRSVG
NTIDPVILFQKMGVGKLEMYVLNPVKSSKEMQYFMQQW---T-GTN-KDKAE-LILPN-G
QEID-IPISYL-TSVSS-LIVWHPANPAEKIIRVLFPGNSTQYNILEGLEKLKHLDFLKQ
PLATQKDLTGQVASPT-VKQVKLKQRADSRESLKPATKPLAS-KSVRKESKEETPDATKV
NH-VEKPPKIESKEKVTVKKDK------PTKAETKPPVTEKEVPSK--EDQPSVKAEVAE
K---QATDVKPKVAKEKVVKKETKLKAEEKKEE--KEKPKKEVAKKEDKTPVKKEEKPKK
EEVKKEVKKEVKKEEKKESKKEVKKETPLKETKKEVKKEEKKEVKKEEKEPKKEIKKLPK
DLKKPSTPLSEAKKPAALKPKVPKKEESVKKDAV-AAGKPKEKGKIKVIKKEVKTTEAAA
A-AI-GTVATAAAMGAAAEIAATGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVAKDI
KPQLELREDEEKLKESEPVEAYVIQKETEVIKGPAESPDEGITTTEGEGECEQTPEELEP
VEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEDAEEPEEDGEENVCVRTSKHSLI--
-------ED-EERAKAEADVYI----K-EKRESVASGDDRAEEDMDEAVEKGETEQSEEE
G--D-EECKAEDAREEEYEPEK-IEAEDYVMAVVDKAAE-AGGVEDQY-GFLTTSAKPLG
AQSPAQEPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPM
DEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYSQEYAKPTT---VTPLNGLSDGS
KTDATDGKDYNASASTISPPSSMEEDKFSKSALHDAYCFGEKEVKVSARLEIKDTSAD--
-LDEKLSPSKSPSLSPSPPSPIEKTPLGERSVNFSLTPNEIKVSTEPEAAP-VSPEVTQE
VVEEHCASPEDKTLEVVSPSQSVTGSAGHTPYYQSPTDEKANHLPTEVIEKPSAVPVSFE
FDD-DKDENEKPSISPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYESFLSADDKALDR
CIESPFEGKNGKQSFPDQISPVSEITSTGLFQEEQEGK-STDFIPIKEDFSQEKKNDDIE
ALSSQPGLALDERKLG-DVSPTQIDVSQFGSFKEDTKMSISEGTVSDKSATPVDEGVAED
TYSHIEGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTF
QETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQDHRS-EQSSMSIEFGQESPEHSLAM
DFSRQSPDQPTVGASMX-------------------------------------------
-------------------------------------------------KVQTLEGEKLS
PKSDISPLTPRESSPLYSPSFSDSTSAVKESTAASHSSS-SPPMDAASAEPYGFRSSMLF
DTMQHHLALNRDLTPSGVEK---DSGGKTPGDFSYAYQKAEKTTRSPDE-EGYTYESYEK

PF00414 // ENSGT00550000074593_0_Domain_5 (2101, 2117)

TTRTPEVGGYYYEKTERTTKSPTDGGYTYETIEK

PF00414 // ENSGT00550000074593_0_Domain_7 (2135, 2151)

TTKTPEDGGYAYEITE

ENSGT00550000074593_0_Linker_7_9 (2151, 2152)

K

PF00414 // ENSGT00550000074593_0_Domain_9 (2152, 2168)

TTRTPEEGG
YSYEISE

ENSGT00550000074593_0_Linker_9_10 (2168, 2170)

KM

PF00414 // ENSGT00550000074593_0_Domain_10 (2170, 2185)

TKTPEVSGYSYEKAERS-RRLLDDISNGYDDSEG

PF00414 // ENSGT00550000074593_0_Domain_12 (2204, 2220)

GGHTLGDSSYSYETTEK
IAT-FPESESYSYEASTKM

PF00414 // ENSGT00550000074593_0_Domain_14 (2240, 2256)

TRAPDTS-TYCYETTEKITRTPQTTTYSYETP---------
--------DRC---YTAE--------------KKSPSEARQDVDLCLVSSCEYKHPKTEL
SPSFINPNPLEWFASEEPTEESEKPLTQSGGAPPPPGGKQQGRQCDETPPTSVSESAPSQ
TDSDVPPETEECPSITADANIDSEDESETIPTDKTVTYKHMDPPPAPVQDRSPSPRHPDV
SMVDPEALAIEQNLGKALKKDLKEKAKTKKPGTKTKSSSPVKKGDGKSKPSTASPKPGGL
KDSSDKVSRVASPKKKESVEKATKPT-STPEVK--AARGEEKDKETKNATNASTSKSVKT
AT---A-GPGATKTAKSSAVPPGPPVYLDLCYIPNHSNSKNVDVEFFKRVRSSYYVVSGN
DPAAEEPSRAVLDALLEGKAQWGSSMQVTLIPTHDSEVMREWYQETHEKQQDLNIMVLAS
SSTVVMQDESFPACKIEL

------------------------------------------------------------
------------------------------------------------------------
-----MATVVVEAAEPEPSGSIANPAASTSPSLSHRFLDSKFYLLVVVGEIVTEEHLRRA
IGNIE-LGIRSWDTNLIECNLDQELKLFVSRHSARFSPEVP-----------GQKILHHR
SDVLETVVLINPSDEAVSTEVRLMITDAARHKLLVLTGQCFENTGELILQSGSFSFQNFI
EIFTDQEIGELLSTTHPANKASLTLFCPEEGDWKNSNLDRHNLQDFINIKLNSASILPEM
EGLSEFTEYLSESVEVPSPFDILEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFNML
INGGSERKSCFWKLIRHLDRVDSILLTHIGDDNLPGINSMLQRKIAELEEEQSQGSTTNS
DWMKNLISPDLGVVFLNVPENLKNPEPNIKMKRSIEEACFTLQYLNKLSMKPEPLFRSVG
NTIDPVILFQKMGVGKLEMYVLNPVKSSKEMQYFMQQW---T-GTN-KDKAE-LILPN-G
QEID-IPISYL-TSVSS-LIVWHPANPAEKIIRVLFPGNSTQYNILEGLEKLKHLDFLKQ
PLATQKDLTGQVATPA-VKQVKLKQRADSRESLKPATKPLPS-KSVRKESKEETPDVAKA
NH-VEKAPKVESKEKVTVKKDK------PVKTETKPLVTEKEVPSK--EELPPVKAEVAE
K---PATDVKPKVAKEKTVKKETKAKSEEKKEE--KEKPKKEVAKKEDKTPIKKEEKPKK
EEVKKEVKKEIKKEEKKEPKKEVKKETPLKEAKKEVKKEEKKEVKKEEKEPKKEIKKLPK
DTKKSSTPLPEAKKPAALKPKVPKKEEAVKKDSV-AAGKPKEKGKIKVVKKEGKTPEAAA
A-AI-GSVAAATAVVAAAGIASAGPAKEL

PF00183 // ENSGT00550000074593_0_Domain_1 (990, 1015)

EAERSLMSSPEDLTKDFEELKAEEV

ENSGT00550000074593_0_Linker_1_2 (1015, 1490)

DVAKDM
KPQLELIEDEEKLKETEPVEAYVIQKETEVIKGSAESPDEGITTTEGEGECEQTPEELEP
VEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDVEENVCVSTSKHSLM--
-------EE-EESAKAEADVHI----K-EKRESLASGDDRAEEDMDEVVEKGEGEQSEEE
G--D-EEDRAEDAREEEYEPEK-AEAEDYVMAVVDKAAE-ASGVEDQY-GFLTTAIKQPG
AQSPAREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPM
DEMSTPRDVMSDEINNEETESPSQEFVNITKYESTLYSQEYCKP-A---VTSLNGLSEGS
KTDATDGKDYNASASTISPPSSMEEDKFSKSALRDAYCSEDKDLKASATLTIKDTISA--
VSDEKLSPPKSPSLSPSPPSPIEKTPLGERSVNFSLTPNEIQVSAEAEA

PF02818 // ENSGT00550000074593_0_Domain_2 (1490, 1516)

AP-VSPEVTQE
VVEEHCASPEDKTLEVVSPSQSVTGSAGHTPYYQSPTEEKSSHLPTEVIEKPPAVPVSFE
FSD-AKDENERASISPMDEPVPDSESPIEKVLSPLRSPPLIGSEAAYEGFLSADDKVADR
GAESPFEGKNGKQAFPDEMSPVSDITSTGLFQDKEEGK-STDFIPIKEDYGQEKKTDDVE
AMSSQSGLALDERKLGGDVSPTQIDVSQFGSFKEDTKMSISEGTVSDKSATPVDEGVAED
TYSHMEGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTF
QETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQDHRS-EQSSMSIEFGQESPEHSLAM
DFSRQSPDHPTVGASMLHITENGPTEVDYSPSDMQDSSLSHKIPAMEEP-SYTQDNDLSE
LISVSQVEASPSTSSAHTPSQIASPLQEDTLSDVIPPRDISLYASLTSEKVQSLEGEKLS
PKSDISPLTPRESSPLYSPSFSDSTSAVKENIAVCHTSS-PPPMDAASAEPYGFRASMLF
DTMQHQLALNRDLTLSGVEK---DSGGKTPGDFSYTYPKPEK

PF00414 // ENSGT00550000074593_0_Domain_4 (2083, 2100)

TTRSPDE-EGYDYESYE

ENSGT00550000074593_0_Linker_4_5 (2100, 2101)

K

PF00414 // ENSGT00550000074593_0_Domain_5 (2101, 2117)

TTQPPDVSGYYYEKTE

ENSGT00550000074593_0_Linker_5_6 (2117, 2118)

R

PF00414 // ENSGT00550000074593_0_Domain_6 (2118, 2134)

TAKSPCDSSYSYDTVE

ENSGT00550000074593_0_Linker_6_7 (2134, 2135)

K

PF00414 // ENSGT00550000074593_0_Domain_7 (2135, 2151)

TTKTPEDGGYAYDIAE

ENSGT00550000074593_0_Linker_7_9 (2151, 2152)

K

PF00414 // ENSGT00550000074593_0_Domain_9 (2152, 2168)

TTRTPEEGE
YSYETSE

ENSGT00550000074593_0_Linker_9_10 (2168, 2169)

K

PF00414 // ENSGT00550000074593_0_Domain_10 (2169, 2185)

MMRTPEVSGYSYEKTERS-RRLLDDISNGYDDSED

PF00414 // ENSGT00550000074593_0_Domain_12 (2204, 2220)

GGHTLGDSSYSYETTEK
IAS-FPESESFSYETSTT

PF00414 // ENSGT00550000074593_0_Domain_14 (2239, 2256)

ATRIPDAS-TYCYETTE

ENSGT00550000074593_0_Linker_14_15 (2256, 2257)

K

PF00414 // ENSGT00550000074593_0_Domain_15 (2257, 2290)

ITRTPQASTYSYETS---------
--------DQC---YTAE--------------KKSPSEARQDVDLCLVSSCEYKHPKTEL
SPSFINPNPLEWFASEEPTEESEKPLTQAGGAPPPPGGKPQGRQCDETPPTSVSESAPSQ
TDSDVPPETEECPSITADANIDSEDESETIPTDKTVTYKHMDPPPAPMQDRSPSPRHPDV
SMMDPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKGDGKSKPSAASPKPAGL
KESSDKVSRVASPKKKESVEKATKTT-TTPEVK--AARE-EKDKDTKNAANTSTSKSVKT
AA---A-GPGTTKPSKPSAVPPGPPVYLDLCYIPNHSNSKNVDVEFFKRVRSSYYVVSGN
DPAAEEPSRAVLDALLEGKAQWGSNMQVTLIPTHDSEVMREWYQETHEKQQDLNIMVLAS
SSTVVMQDESFPACKIEL

------------------------------------------------------------
------------------------------------------------------------
-----MATVVVEAAEPEPSGSIANPAATTSPSLSHRFLDSKFYLLVVVGEIVTEEHLRRA
IGNIE-LGIRSWDTNLIECNLDQELKLFVSRHSARFSPEVP-----------GQKILHHR
SDVLETVVLINPSDEAVSTEVRLMITDAARHKLLVLTGQCFENTGELILQSGSFSFQNFI
EIFTDQEIGELLSTTHPANKASLTLFCPEEGDWKNSNLDRHNLQDFINIKLNSASILPEM
EGLSEFTEYLSESVEVPSPFDILEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFNML
INGGSERKSCFWKLIRHLDRVDSILLTHIGDDNLPGINSMLQRKIAELEEEQSQGSTTNS
DWMKNLISPDLGVVFLNVPENLKNPEPNIKMKRSIEEACFTLQYLNKLSMKPEPLFRSVG
NTIDPVILFQKMGVGKLEMYVLNPVKNSKEMQYFMQQW---T-GTN-KDKAE-LILPN-G
QEID-IPISYL-TSVSS-LIVWHPANPAEKIIRVLFPGNSTQYNILEGLEKLKHLDFLKQ
PLATQKDLTGQVATPA-VKQVKLKQRADSRESLKPAAKPLPS-KTVRKESKEETPEVTK-
-G-LEKAPKVESKEKVMVKKDK------PVKTETKPPVTEKETPSK--EELPPAKAEGAE
K---QGTDVKPKVAKEKTVKKETKPKPEEKKEEKEKEKPKKEVAKKEDKTPVKKEEKPKK
EEVKKEVKKEIKKEEKKEIKKEVKKETPLKEAKKEVKKEEKKEIKKEEKEPKKEIKKLPK
DTKKSPTPVAEAKKPAALKPKVPKKEEPVKKESV-AAGKPKEKGKIKVVKKEGKTAEAAA
A-AL-GTVAAAA---AVAGLATTGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVAKDI
KPQLELIEDEEKLKQTEPVEAYVIQKETDVIKGPAESPDEGITTTEGEGECEQTPEELEP
VEKQGVEDTEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDTEDHVRVSTSKHSLA--
-------EE-EESAKAEADAHI----K-EKRESVASGDDRAEEDMDEALEKGEAEQSEEE
A--E-EEDRAEDAREEDYEPEK-AEAEDYVRAVVDKAAE-ASRAEAEY-GFLTAAPKPGG
AQSPIREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPM
DEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYSQEYAKP-A---VTSLNGLSDGS
KTDATDGRDYNASASTISPPSSMEEDKFSRSALRDAYYSEDKDVRAGATLEIKDTVSP--
VLDEKLSPPKSPSLSPSPPSPIEKTPLGERSVNFSLTPNEIEVSAEAEVAP-VSPEVTQE
VVEEHCASPEDKTLEVVSPSQSVTGSAGHTPYYQSPTEEKSSHLPTEVIEKPAAVPVSFE
FSD-AKDESERASISPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYESFLSADDKAPGR
GTESPFEGKDGKEASPDQISPVSDMTSTGLFQDKQEGK-STDFIPIKEDFGQEKKTDDVE
DMSSQSGLTLDERKLGGDVSPTQIDVSQFGSLKEDTKMSISEGTVSDKSATPVDEGVVED
TYSHMEGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTF
QETEMSPSKEECPRPMSISPPDFSPKTAKSQTPVQDHRS-EQSSMSIEFGQESPEHSLAM
DFSRQSPDHPTVGAGMLHITENGPTEVDYSPSDMQDSSLSHKIPPTEEP-SYTQDNDLSE
LISVSQVEASPSTSSAHTPSQIASPLQEDTLSDVVPPRDISLYASLTSEKVQSLDAEKLS
PKSDISPLTPRESSPLYSPSFSDSTSAVKESTAACHTAS-PPPMDAASAEPYGFRASMLF
DTMPHHLALNRDLTTPGMEK---DTGGKTPGDFSYAYQKPETTTRSPDE-EGYDYEAYEK

PF00414 // ENSGT00550000074593_0_Domain_5 (2101, 2116)

TTRTPDVSGYYYEKT

ENSGT00550000074593_0_Linker_5_6 (2116, 2119)

ESV

PF00414 // ENSGT00550000074593_0_Domain_6 (2119, 2134)

TKSPCDSSYSYETMEKTSKTPEDGGYAYEITEK

PF00414 // ENSGT00550000074593_0_Domain_9 (2152, 2168)

TTRSPEESG
YAYEISE

ENSGT00550000074593_0_Linker_9_10 (2168, 2169)

K

PF00414 // ENSGT00550000074593_0_Domain_10 (2169, 2185)

TIRTPEVSAYSYEKTERS-RRLLDDISNGYDDSEEG

PF00414 // ENSGT00550000074593_0_Domain_12 (2205, 2220)

GHTLGDSSYSYETTEK
TAG-FPESESYSYEPSTT

PF00414 // ENSGT00550000074593_0_Domain_14 (2239, 2256)

TTRSPDAS-AYCYETPEKITRAPQASSYAYETS---------
--------GQC---YTAE--------------KKSPSEARQDVDLCLVSSCEYKHPKTEL
SPSFINPNPLEWFASEEPTEESEKPLTQSGGAPPPPGGKPQGRQCDETPPTSVSESAPSQ
TDSDVPPETEECPSITADANIDSEDESETIPTDKTVTYKHMDPPPAPMQDRSPSPRHPDV
SMMDPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKGDGKSKPSAASPKPGAL
KESSDKVSRVASPKKKESVEKATKTT-TTPEVK--AARGEEKDKETKNAANASTSKSVKT
AT---A-GPGTTKTSKPSAVPPGPPVYLDLCYIPNHSNSKNVDVEFFKRVRSSYYVVSGN
DPAAEEPSRAVLDALLEGKAQWGSNMQVTLIPTHDSEVMREWYQETHEKQQDLNIMVLAS
SSTVVMQDESFPACKIEL

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------VSGQKILHHR
SDILETVVLINPSDEAVSTEVRLMITDAARHKLLVLTGQCFENTGELILQSGSFSFQNFI
EIFTDQEIGELLSTTHPANKASLTLFCPEEGDWKNSNLDRHNLQDFINIKLNSSSILPEM
EGLSEFTEYLSESVEVPSPFDILEPPTSGGFLKLSKPCCYIFPGGRGDSALFSVNGFNML
INGGSERKSCFWKLIRHLDRVDSILLTHIGDDNLPGINSMLQRKIAELEEEQSQGSTTNS
DWMKNLISPDLGVVFLNVPENLKNLDPNIRVKRSVEEACFTLQYLNKLSMKPEPLFRNVG
NTIDPIILFQKMGVGKLEMYVLNPVKNSKEMQYFMQRWSGTS-----KDKAE-FLLPN-G
QELD-IPLSYF-TSVSS-LIVWHPANPAEKIIRVLFPGNSTQYNILEGLEKLKHLDFLKQ
PMVTQKDLTGNIASPA-VKQAKLKQRTDSKESLKPAAKTPPS-KIVRKESKEETPEPAKP
SPAPEKTQKLESKEKVPVKKEK------PAKPEAKPIVAEKDITSK---EEQLLKSETPE
K---QATDVKPKVTKEKP------------------------------------------
------------------------------------------------------VKKVPK
ETKKTPTPSAESKKP-AAKPKPQKKEEPAKKEA-VPAGKPKEKGKIKTVKKEIKVSGAQA
ALAAVGAAATTVAAVAAAEI--TASGKELEAERSLMSSPEDLTKDFEELKAEEVETIKTT
KPQVALIEDELKLSGKEQKEAFDIQKEKLDNEGPAESSDEGITTTEAEGECGQTPEELEP
VEKHRVDDNEKFEDEGTGLEESSEAGDYEEKAETEEAEERGEDEEEKTPLDTTKPYMEEA
RKVGKSAE----EIMAETDANIKDEKYIEK------------------------------
---------------ADY---EASDERDYVMAVVDKAAE-AGEVEDKYGLLIITPTKCSE
PQSPAVEPASSIHDETLPGGSESEATVSDEENREDQPEEFTATSGYTQSTIEIS-EPTPM
DEMSTPRDVMSDETNNEESESPSQEYVNITKYETSLYSQEFGRPKLSPLPDALNGLSEGS
KTEATEGRDYNASASTISPPSSLEEDKFCKSVFQDVYRQKESEIQGTAKLEIKETCPE--
DVSGKLSPAKSPADSLSPPSPVAKTPLGERSVNFSLIPNEIKVLAEPAPVA-ALPSVRQE
VAEEHCASPEDKTLEVASPSQSAAGSAGHTPYYQSPTDEKSSQLPSETSEKSTEAPVSFE
FSE-VKDESAKPRISPMDEPVPDSESPIEKVLSPLQSPPLIGSETTYDTFLSDDVKCPTR
DYGSPSEGKPEKEKSPVQMSPASEASSVGLFQERQDEK-SMEFMVIKEGFSLERRMEDTE
PSSSQSSLVLDERKLTGDLSPTQIDISQFGSLKEDTKMSISEGTVSDKSATPVDEVIAED
TYSHIEGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTF
QETEMSPSKEECPRPMSISPQDFSPKTAKSRTPVHDHRSPEQSTMSVEFGQESPEQSLAM
DFSRQSPEYPTVGISIHHISVNGPTEVDYSPSDIQEPTFAQKISPVEQT-SYSQEKDISE
IISVSQIEASSSSSSAHTPSQVTSPLPEETFAGAAPPRDMSLHSSLTSEKVQSL-GEKLS
PKSDLSPLSPRESSPLYSPSFPDSPPAVTEAVSASHASSLS--LEVSSDKAFGYQAVTLQ
EPLE----KHSPEPLFSPEKEDSEK

PF00414 // ENSGT00550000074593_0_Domain_3 (2066, 2082)

SSRSPEELSYSYEATE

ENSGT00550000074593_0_Linker_3_4 (2082, 2083)

K

PF00414 // ENSGT00550000074593_0_Domain_4 (2083, 2100)

TARSPED-ISYSYEAVG

ENSGT00550000074593_0_Linker_4_5 (2100, 2101)

K

PF00414 // ENSGT00550000074593_0_Domain_5 (2101, 2117)

STKSPEATDYSYETTG

ENSGT00550000074593_0_Linker_5_6 (2117, 2118)

K

PF00414 // ENSGT00550000074593_0_Domain_6 (2118, 2134)

TSRSPEATDYSYEMTG

ENSGT00550000074593_0_Linker_6_7 (2134, 2135)

K

PF00414 // ENSGT00550000074593_0_Domain_7 (2135, 2151)

TTRSPGDTDYSYETTG

ENSGT00550000074593_0_Linker_7_9 (2151, 2152)

K

PF00414 // ENSGT00550000074593_0_Domain_9 (2152, 2168)

TTRSPEATD
YSYEIIG

ENSGT00550000074593_0_Linker_9_10 (2168, 2169)

K

PF00414 // ENSGT00550000074593_0_Domain_10 (2169, 2185)

TTKSLDVTDYSYERIGKATK--------------------------------
----SLDAMDYSFEATGK

PF00414 // ENSGT00550000074593_0_Domain_14 (2239, 2256)

TTKSPET-MDYCYETTG

ENSGT00550000074593_0_Linker_14_16 (2256, 2257)

R

PF00414 // ENSGT00550000074593_0_Domain_16 (2257, 2273)

TTRSPEATAYSYETTGKSTSSPEA
TDYSFETTEQATRS--PEPTSYSYEASAHFTPGKSLAESCQDVDLCLVSSCEYKHPKTEL
SPSFINPNPLEWFASEEQSQDQEKPLTQSGGAQPPSGGKQQGRQCDETPPTSVSESAPSQ
TDSDVPPETEECPSITADANIDSEDESETIPTDKTITYKHIDPPPVPIQDHSPSPRHPDV
SMVDPEALPVDQNLGKPLKKDLKEKTKTKKQGTKTKSSSPVKKSDGKSKQVA-SPKP-AV
KESLEKTSKTASPKKKESVEKATKNI-SNPEVK---SRVEEKDKDTKNAANTTASKSAKT
ATT----GPGTTKSAKSTAVPPGPPVYLDLVYIPNHSNSKNVDVEFFKRVRSSYYVVSGN
DAAAEEPSRAVLDSLLEGKAQWESNMQVTLIPTHDSEVMREWYQETHEKQQDLNIMVLAS
SSTVVMQDESFPACKIEL

------------------------------------------------------------
------------------------------------------------------------
-----MATVVVEATEPEPSGSIANPAASTSPSLSHRFLDSKFYLLVVVGEIVTEEHLRRA
IGNIE-LGIRSWDTNLIECNLDQELKLFVSRHSARFSPEVP-----------GQKILHHR
SDVLETVVLINPSDEAVSTEVRLMITDAARHKLLVLTGQCFENTGELILQSGSFSFQNFI
EIFTDQEIGELLSTTHPANKASLTLFCHEEGDWKNSNLDRHNLQDFINIKLNSASILPEM
EGLSEFTEYLSESVEVPSPFDILEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFNML
INGGSERKSCFWKLIRHLDRVDSILLTHIGDDNLPGINSMLQRKIAELEEEQSQGSTTNS
DWMKNLISPDLGVVFLNVPENLKNPEPNIKMKRSIEEACFTLQYLNKLSMKPEPLFRSVG
NTIDPVILFQKMGVGKLEMYVLNPVKSSKEMQYFMQQW---T-GTN-KDKAE-FILPN-G
QEVD-LPISYL-TSVSS-LIVWHPANPAEKIIRVLFPGNSTQYNILEGLEKLKHLDFLKQ
PLATQKDLTGQVPTPV-VKQTKLKQRADSRESLKPAAKPLPS-KSVRKESKEETPEVTKV
NH-VEKPPKVESKEKVTVKKDK------PVKTETKPSVTEKEVPSK--EEPSPVKAEVAE
K---QATDVKPKAAKEKTVKKETKVKPEDKKEE--KEKPKKEVAKKEDKTPIKKEEKPKK
EEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKEVKKEEKEPKKEIKKLPK
DAKKSSTPLSEAKKPAALKPKVPKKEESVKKDSV-AAGKPKEKGKIKVIKKEGKAAEAVA
A-AV-GTGATTAAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVTKDI
KPQLELIEDEEKLKETEPVEAYVIQKEREVTKGPAESPDEGITTTEGEGECEQTPEELEP
VEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEEHICVSASKHSPT--
-------ED-EESAKAEADAYI----R-EKRESVASGDDRAEEDMDEAIEKGEAEQSEEE
A--D-EEDKAEDAREEEYEPEK-MEAEDYVMAVVDKAAE-AGGAEEQY-GFLTTPTKQPG
AQSPGREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPM
DEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYSQEYSKPAD---VTPLNGFSEGS
KTDATDGKDYNASASTISPPSSMEEDKFSRSALRDAYCSEVK---ASTTLDIKDTISA--
VSSEKVSPSKSPSLSPSPPSPLEKTPLGERSVNFSLTPNEIKVSAEAEVAP-VSPEVTQE
VVEEHCASPEDKTLEVVSPSQSVTGSAGHTPYYQSPTDEKSSHLPTEVIEKPPAVPVSFE
FSD-AKDENERASVSPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYESFLSADDKASGR
GAESPFEEKSGKQGSPDQVSPVSEMTSTSLYQDKQEGK-STDFAPIKEDFGQEKKTDDVE
AMSSQPALTLDERKLG-DVSPTQIDVSQFGSFKEDTKMSISEGTVSDKSATPVDEGVAED
TYSHMEGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTF
QETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQDHRS-EQSSMSIEFGQESPEQSLAM
DFSRQSPDHPTVGAGVLHITENGPTEVDYSPSDMQDSSLSHKIPPMEEP-SYTQDNDLSE
LISVSQVEASPSTSSAHTPSQIASPLQEDTLSDVAPPRDMSLYASLTSEKVQSLEGEKLS
PKSDISPLTPRESSPLYSPTFSDSTSAVKEKTATCHSSS-SPPIDAASTEPYGFRASVLF
DTMQHHLALNRDLSTPGLEK---DSGGKTPGDFSYAYQKPEETTRSPDE-EDYDYESYEK

PF00414 // ENSGT00550000074593_0_Domain_5 (2101, 2117)

TTRTSDVGGYYYEKIERTTKSPSDSGYSYETIGK

PF00414 // ENSGT00550000074593_0_Domain_7 (2135, 2151)

TTKTPEDGDYSYEIIEKTTRTPEEGG
YSYDISEKTTSPPEVSGYSYEKTERS-RRLLDDISNGYDDSEDG

PF00414 // ENSGT00550000074593_0_Domain_12 (2205, 2220)

GHTLGDPSYSYETTEK
ITS-FPESEGYSYETSTK

PF00414 // ENSGT00550000074593_0_Domain_14 (2239, 2256)

TTRTPDTS-TYCYETAE

ENSGT00550000074593_0_Linker_14_15 (2256, 2257)

K

PF00414 // ENSGT00550000074593_0_Domain_15 (2257, 2289)

ITRTPQASTYSYETS---------
--------DLC---YTAE--------------KKSPSEARQDVDLCLVSSCEYKHPKTEL
SPSFINPNPLEWFASEEPTEESEKPLTQSGGAPPPPGGKQQGRQCDETPPTSVSESAPSQ
TDSDVPPETEECPSITADANIDSEDESETIPTDKTVTYKHMDPPPAPVQDRSPSPRHPDV
SMVDPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKSDGKSKPLAASPKPAGL
KESSDKVSRVASPKKKESVEKAAKPT-TTPEVK--AARGEEKDKETKNAANASASKSAKT
AT---A-GPGTTKTTKSSAVPPGLPVYLDLCYIPNHSNSKNVDVEFFKRVRSSYYVVSGN
DPAAEEPSRAVLDALLEGKAQWGSNMQVTLIPTHDSEVMREWYQETHEKQQDLNIMVLAS
SSTVVMQDESFPACKIEL

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------IRSWDTNLIECNLDQELKLFVSRHSARFSPEVP-----------GQKILHHR
SDVLETVVLINPSDEAVSTEVRLMITDAARHKLLVLTGQCFENTGELILQSGSFSFQNFI
EIFTDQEIGELLSTTHPANKASLTLFCPEEGDWKNSNLDRHNLQDFINIKLNSASILPEM
EGLSEFTEYLSESVEVPSPFDILEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFNML
INGGSERKSCFWKLIRHLDRVDSILLTHIGDDNLPGINSMLQRKIAELEEEQSQGSTTNS
DWMKNLISPDLGVVFLNVPENLKNPEPNIKMKRSIEEACFTLQYLNKLSMKPEPLFRSVG
NTIEPVILFQKMGVGKLEMYVLNPVKSSKEMQYFLQQW---T-GTN-KDKAE-LILPS-G
QEVD-IPISYL-TSVSS-LIVWHPANPAEKIIRVLFPGNSTQYNILEGLEKLKHLDFLKQ
PLATQKDLTGQVPTPTTTKQVKLKQRADSRESLKPAAKPLTT-KSVRKESKEETPDVTKA
SQ-VEKPPKVESKEKVMVKKDK------PVKTETKPPVTEKEIASK--EELPPARAEVAE
K---QATDVKPKISKEKVVKKETKPKSEEKKEE--KEKPKKEVAKKEEKTLIKKEEKPKK
EEVKREVKKEIKKEEKKELKKEVKKETPLKDAKKEIKKEEKKEIKKDEKEPKKEIKKLSK
DSKKSTTLLSEAKKPAALKPKVPKKEETVKKE-SVAAGKPKEKGKIKVIKKESKTSEAAA
I-GT-VVTTAAA--VAAAGIAATGPAKELEAERSLMSSPEDLTKDFEELKAEEIDVAKDI
KPQLELTEDEEKVKETEPVEAYVIQKETEVIKGPAESPDEGITTTEGEGECEQTPEELEP
VEKQGVDDIEKYEDEGAGFEESSETGDYEEKAETEEAEEPEEDSEENVCVSTSKHSPI--
--------DEEESAKAEADVHI----K-EKRESVASGDDRAEEDMDEAVEKGEAELSEEE
GE---EEDKAEDAREEEYEPEK-AEAEDYVMAVVDK-AAEVSGTEDQY-GFLATSTKQPG
AQSPGRGPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPM
DEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYSQEYAKPG----AAPFNGLSDGS
KTDATEGKDYNVSASTISPPSSMEEDKFTRSALRDAYCPEEKEVKASATLEIQDTTSA--
VSDERLSPAKSPSLSPSPPSPIEKTPLGERSVNFSLTPNEIKVSTEAEAVS-VSPEVTQE
IVEEHCASPEEKTLEVVSPSQSVTGSAGHTPYYQSPTDEKSSHLPTEVIEKPQAVPVSFE
FSDAKDESER-ASISPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYESFLSVDDKAPSR
GSESPFEGKNGKQSFPDQISPVSETTSTGLYQDKQEGK-STDFIPIKEDFSLEKKTDDVE
ALSSHAALALDERKLG-DVSPTQTDVIQFGSFKEDTKMSISEGTVSDKSATPVDEGVAED
TYSHMEGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTF
QETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQDHRS-EQSSMSIEFGQESPEHSLAM
DFSRQSPDHPTVGASVLHITENGPTEVDYSP-DMQDSSLSHKIPPTEEP-SYTQDNDLSE
LISVSQVEASPSTSSAHTPSQIASPLQEDTLSDVAPPRDMSLYASLTSEKVQSLEREKLS
PKSDISPLTPRESSPLYSPGFSDSTSAVKENVA-ACHTSSSPPVDAASSEPYGFRASMLF
DTMQHHLTLNRDLTTSGIED---SGG-KTPGDFGYAYQKPEKTTRSPDEEEDYDYESYEK
S

PF00414 // ENSGT00550000074593_0_Domain_5 (2102, 2117)

TRTPDVGSYYYEKTE

ENSGT00550000074593_0_Linker_5_6 (2117, 2120)

RTL

PF00414 // ENSGT00550000074593_0_Domain_6 (2120, 2134)

KSPCDSGYSYETIEK-TKTPEDGGYACEITEK

PF00414 // ENSGT00550000074593_0_Domain_9 (2152, 2168)

TTRTPEEGG
YSYEISE

ENSGT00550000074593_0_Linker_9_10 (2168, 2169)

K

PF00414 // ENSGT00550000074593_0_Domain_10 (2169, 2185)

TIRTPDVSGYSYEVTERS-RRLLDDISNGYDDSEDVGRTIGDSSYSFETTEK
ITS-FPECESYSYETSTKM

PF00414 // ENSGT00550000074593_0_Domain_14 (2240, 2256)

TRSPDSS-TYCYETME

ENSGT00550000074593_0_Linker_14_15 (2256, 2257)

K

PF00414 // ENSGT00550000074593_0_Domain_15 (2257, 2290)

ITKTPQASAYSYETS---------
--------DRC---YSTE--------------KKCPSEARQEVDLCLVSSCEYKHPKTEL
SPSFINPNPLEWFASEEPTEESEKPLTQLGGAPPPPGGKQQGRQCDETPPTSVSESAPSQ
TDSDVPPETEECPSITADANIDSEDESETIPTDKTVTYKHMDPPPAPMQDRSPSPRHPDV
TMVDPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSSPIKKGDGKSKPLAASPKPGAL
KETSDKVSRVASPKKKEAVEKATKTT-STPEVK--AARGEEKDKETKNAAN--VSKSVKT
AT----PGLGTTKTAKSSTVPPGLPVYLDLCYIPNHSNSKNVDVEFFKRVRSSYYVVSGN
DPAAEEPSRAVLDALLEGKAQWGSNMQVTLIPTHDSEVMREWYQETHEKQQDLNIMVLAS
SSTVVMQDESFPACKIEL

------------------------------------------------------------
------------------------------------------------------------
-----MATVVVEATEPEPSGSIANPAASTSPSLSHRFLDSKFYLLVVVGETVTEEHLRRA
IGNIE-LGIRSWDTNLIECNLDQELKLFVSRHSARFSPEVP-----------GQKILHHR
SDVLETVVLINPSDEAVSTEVRLMITDAARHKLLVLTGQCFENTGELILQSGSFSFQNFI
EIFTDQEIGELLSTTHPANKASLTLFCPEEGDWKNSNLDRHNLQDFINIKLNSACILPEM
EGLSEFTEYLSESVEVPSPFDILEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFNML
INGGSERKSCFWKLIRHLDRVDSILLTHIGDDNLPGINSMLQRKIAELEEEQSQGSTTNS
DWMKNLISPDLGVVFLNVPEHLKNPEPNIKMKRSIEEACFTLQYLNKLSMKPEPLFRSVG
NTIEPVILFQKMGVGKLEMYVLNPVKSSKEMQYFLQQW---T-GTN-KDKAE-LILPS-G
QEVD-IPIPYL-TSVSS-LIVWHPANPAEKIIRVLFPGNSTQYNILEGLEKLKHLDFLKQ
PLATQKDLTGQVPTPTTAKQVKLKQRADSRESLKPAAKPLPT-KSVRKESKEETPDIAKA
NQ-VEKPPKVESKEKAVVKKDK------PIKTETKAPVSEKEVASK--EEQPPAKAEVAE
K---QATDVKPKVAKEKVVKKDTKPKSEEKKEE--KEKPKKEVAKKEEKTPIKKEEKLKK
EEVKKEVKKEIKKEEKKELKKEVKKETPLKEPKKEVKKEEKKEIKKEEKEPKKEIKKLPK
DSKK-TTPLAEAKKPAALKPKVPKKEETVKKE-SVAAGKPKEKGKVKVIKKEAKPSEAAA
I-GT-VATTAAV--VAAAGIVATGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVVKDI
KPQLELIEDEEKGKETEPVEAYVVQKETEVIKGPAESPDEGITTTEGEGECEQTPEELEP
VEKQGVDDIEKYEDEGAGFEESSETGDYEEKAETEEAEEPEEDSEENVCVSTSKHSPV--
--------DEEESAKVEADVHL----K-EKRESVASGDDRAEEDMDEAVEKGEAELSEEE
GE----EDKAEDAREEEYEPEK-AEAEDYVMAVVDK-AAEAGG-TDQY-GFLATSAKQPG
AQSPGREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPM
DEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYAQEYTKPA----VTPFNGLSDGS
KTDATEGKDYSVSASTISPPSSMEEDKFTRSALRDAYYSEEKAVKPSDTLEVQDTTSA--
VSDERLSPVKSPSLSPSPPSPIEKTPLGERSVNFSLTPNEIKVSTEAEAVS-VSPEVTQE
VVEEHCASPEEKTLEVVSPSQSVTGSAGHTPYYQSPTEEKSSHLPTEVIEKPQAVPVSFE
FSDAKDESER-ASVSPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYESFLSVDDKAPSR
GSESPFEGKNGKQGFPDQISPVSEMTSTGLYQDKQEGK-STDFIPIKEDFSPEKKTDDVE
AMSSHAALALDERKLG-DVSPTQIDVIQFGSFKEDTKMSISEGTVSDKSATPVDEGVAED
TYSHMEGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTF
QETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQDHRS-EQSSMSIEFGQESPEHSLAM
DFSRQSPDHPTAGVGVLHITENGPTEVDYSPSDMQDSSLSHKIPLAEEP-SYTQDNDLSE
LISVSQVEASPSTSSAHTPSQIASPLQEDTLSDVAPPRDMTLYASLTSEKVQSLEGEKLS
PKSDISPLTPRESSPSYSPGFSDSTSAVKESTA-VHRTSSSPPVDSASAEPYGFRASMLF
DTMQHHLTLDRDLTTSGIEK---DGGEKVPGDFSYAYQKPEKTTGSPDE-DDYDYESYGK

PF00414 // ENSGT00550000074593_0_Domain_5 (2101, 2117)

TTRTPDVGSYYYEKTE

ENSGT00550000074593_0_Linker_5_6 (2117, 2120)

RTV

PF00414 // ENSGT00550000074593_0_Domain_6 (2120, 2134)

KSPCDSGYSYETIEK-TKTPEDGGYACEITEK

PF00414 // ENSGT00550000074593_0_Domain_9 (2152, 2168)

TTRTPEEGG
YSYEISE

ENSGT00550000074593_0_Linker_9_10 (2168, 2169)

K

PF00414 // ENSGT00550000074593_0_Domain_10 (2169, 2185)

TIRTPEVSGYSYEATERS-RRLLDDISNGYDDSEDGGHTLGDTSYSCETTEK
ITS-FPESESYSYEMSTKM

PF00414 // ENSGT00550000074593_0_Domain_14 (2240, 2256)

TRSPDSS-TYCYETME

ENSGT00550000074593_0_Linker_14_15 (2256, 2257)

K

PF00414 // ENSGT00550000074593_0_Domain_15 (2257, 2290)

ITKTPQASTYSYETS---------
--------DRC---YSAE--------------KKSPSEARQEVDLCLVSSCEYKHPKTEL
SPSFINPNPLEWFASEEPTEESEKPLTQSGGAPPPPGGKQQGRQCDETPPTSVSESAPSQ
TDSDVPPETEECPSITADANIDSEDESETIPTDKTVTYKHMDPPPAPMQDRSPSPRHPDV
TMVDPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKGDGKSKPSAASPKPGPL
KEPSDKVSRVASPKKKESVEKATKTT-ATPEVK--ASRGDEKDKETKNAAN--VSKSVKT
AT----AGPGTTKTAKSSTVPPGLPVYLDLCYIPNHSNSKNVDVEFFKRVRSSYYVVSGN
DPAAEEPSRAVLDALLEGKAQWGSNMQVTLIPTHDSEVMREWYQETHEKQQDLNIMVLAS
SSTVVMQDESFPACKIEL

------------------------------------------------------------
------------------------------------------------------------
-----MATLLVEATE----LSIASPEASTSPSLSHCSRDSKFYLLVVLSEIVTEEHLRRA
IGNIE-LGIRSWDTNLIECNLDQELKLFVSRHSARFSPEVP-----------GQKILHHR
SDVLETVVLINPSDEAVSTEVRLMITDAARHKLLVLTGQCFENTGELILQSGSFSFQNFI
EIFTDQEIGELLSTTHPANKASLTLFCPEEGDWKNSNLDRHNLQDFINIKLNSASILPEM
EGLSEFTEYLSESVEVPSPFDILEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFNML
INGGSERKSCFWKLIRHLDRVDSILLTHIGDDNLPGINSMLQRKIAELEEEQSQGSTTNS
DWMKNLISPDLGVVFLNVPENLKNPEPNIKMKRSLEEACFTLQYLNRLSMKPEPLFRSVG
NAIEPVILFQKMGVGKLEMYVLNPVKSSKEMQYFMQQW---T-GTH-KDKAE-LLLPN-G
QEVD-IPISYV-TSVSS-LIVWHPANPAEKIIRVLFPGNSAQYNILEGLEKLKHLDFLKQ
PLATQKDLSGQAASPA-VKQVKLKQRADSRESLKPAPKPLPSGKSVRKESKEEAPEVPKA
NQ-VEKPPKVESKDKVTVKKDK------PTKTETKPAASEKQAPSK--EDQPSVKAEVAD
K---QAAEVKPKVTKEKTVKKETKLKSEEKKEE--KEKPKKEVVKKEEKTPVKKEDKAKK
EEVKKEVRKEVKKEEKKESKKEVKKETPLKDAKKEAKKDEKKEAKKEEKEPKKEIKKISK
DAKKSSTPLSDAKKPTALKPKVPKKEEPVKKDAAAAAAKSKEKGKVKVTKKGTA---EAA
AAAI-GTVAAAATGAVAAGIAAAGPAKDL

PF00183 // ENSGT00550000074593_0_Domain_1 (990, 1015)

EAERSLMSSPEDLTKDFEELKAEEVDVAKDR
QPPLALAEDEDKRREPAPGDAYVIQCETEVPPGPAESPDEGITTTEGEGECEQTPEELEP
VEKQGGEDMEKFEDEGAAFEESSEAGDYEEKAETEEPEE---DGDSASS---AKRSP---
-----VQQEEDEPAPAEAHGPL----R-EKRASVASGDDRAEEDMDEALEKGEAAPSEEE
G--D--EDKAEDAREAEYEAGR-AEAEDYVMAVVDKAAE-AGGAEDQY-GFLGASGKPPG
AQSPAREAAATIHDETLPGGSESEATVSDEDNREDQPEEFTATSGYTQSTIEISSEPTPM
DEMSTPRDVMSDETNNEDTESPSQEFVNVTKYESSLYAQEYSKPG-----VSLNGLSEGS
KTDATDGKDYNASASTISPPSSMEEDKFSKSALRDAYCAEERGAKGSAALELPDAPAV--
PDDSRSPSKSPLSLSPSPPSPIEKTPLGERSVNFSLTPNQISVSAAA-TIP-ASPEVTQE
VVEAHCASPEDQTLEVVSPSQSVTGSAGHTPYYQSPTDEKASHLPTEVGGKPAAAPESFE
FDD-TKD--ERLSISPMDEPVPDSASPIEKVLSPLRSPPRIGSESAYESFLSVDEKTPSR
-CRSPFEGTDGEQSILDQISPVAEITSTGLFQERPEKA-SADFVPIKEDSEKGQTTEDVE
ALGSPPGLAS-GRKLGGEVSPTQIDVSQFGFLKEDTKMSISEGTVSDKSATPVDEGVAED
TYSHLEGVASVSTASVATNSFPEPTTDDVFPSLHAEVGSPHSTEVDDSLSVSVVQTPTTF
QETEVSPSKEECPRPMSISPPDFSPKTAKSGTPVQDHRS-EQSSMSIEFGQESPEHSLAM
DFSRQSPDHPAVGAGMLHITENGPTEVDYSP-DLQDSSLSHKIPPVEEP-SYTQDNDLSE
LISVSQVEASPSTSSAHTPSQIASPLQEDTLSDVVPPREISLYASLTSEKVQLPEGEKLS
PKSDISPLTPREASPLYSPSFSDATSAARENAAXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXX---XXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXX-XXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXX---------
--------XXX---XXXX--------------XXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXPKSPSPEAYSFSPIKKADREIKHLASPRHPSHH
G----EDCRSSSPKKKESVK--ASKT-TAPEVK--AARGEEKDRETKNATNVSTSKSVKT
AAA---------------------------------------------------------
------------------------------------------------------------
------------------

------------------------------------------------------------
------------------------------------------------------------
-----MATVVVEA-ESEPSCSIPNPT-STSPSLSHRFLDSKFYLLVVIGEIVTEEHLRRA
IGNIE-QGIRSWDTNLIECNLDQELKLFVSRHSARFSPDVR-----------GQKILHHR
SDVLETVVLINPSDEAVSTEVRLMITDAARHKLLVLTGQCFENTGELILQSGSFSFQNFI
EIFTDQEIGELLSTTHPANKASLTLFCPEEGDWKNSNLDRHNLQDFINIKLNSASILPEM
EGLSEFTEYLSESVEVPSPFDILEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFNML
INGGSERKSCFWKLIRHLDRVDSILLTHIGDDNLPGINSMLQRKIAELEEEQSQGSTTNS
DWMKNLISPDLGVVFLNVPENLKNPDPNIKMKRSIEEACFTLQYLNKLSMKPEPLSRNVG
NTIDPVILFQKMGVGKLEMYVLNPVKSSKEMQYFMNQW---T-GTN-KDKAE-LILPN-G
QEVD-IPISYL-TSVSS-LIVWHPANPAEKIIRVLFPGNSTQYNILEGLEKLKHLDFLKQ
PLVTQIDLSGQVASPA-VKQVKLKQRTDSRESLKPAAKTLSS-KPIRKESKEEIPEATKI
NH-VENAPKIESKEKVIVKKDK------PIKTETKPSVPKKEVSNK--EDHSVVKAEVPE
K---QATVVKPKVTKDKFVKKEVKAKSDDKKEE--KEKPKKEVSKKDEKTLLKKEEKPKK
EDVKKEVKKEEKKELK--------------------------------KEVKKDIKKVPK
DSKKLSTSLSDAKKP-ILKPKVQKKEEPIKKETT-ALGKPKEKGKIKVVKKESKLSETPA
AAAI-GTAATAAAVVAAAGIATTGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVLKET
KPQLELIEDEEKLAETEQVEAYVIQKETEVIKGSAESPDEGITTTEVEGECEQTPEELEP
TEKHREDDNEKFEDEGTGFEESSEAGDYEEKAETEEAEEPDYEGEENVSQISAKHGTE-V
VRALDEEEEAEEDRKVEADGHS----K-EKRESLAGGDERAEEDMNEIIEKAEAEETEEE
L--D-EEEKTEDARDDEYDMEKHLAEEDYVMAVVDKAAE-AGDAEDKY-GLLLTPNKQSG
AQSPAREPASSIHDETLPGGSESEATVSDEENREDQPEEFTATSGYTQSTIEISSEPTPM
DEMSTPRDVMSDETNNEESESPSQEFVNITKYESSLYSQEYTKPKL---PDAFNGLSDGS
KTDATDGKDYNASASTISPPSSMEEDKFSRSVLQDAYHSGDRDMKTTTMLEIKDGPSA--
VADEKISPAKSPSLSPAPLSPVAKTPLGERSVNFSLTPNEIKVSDEAGVIT-KSPEVPQE
VLEEHCASPEDKTLEVVSPSQSVAGSAGHTPYYQSPTDEKSSHIPSDVTEKAPPVPVSFE
FDD-AKDENGKTSISPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYDTFLSTDIKTSVR
HIESPLEEKIGKQDSPSQRSPVSETTSTDIFPEKQDEK-CTEFIPIKEELGQEKKMEDFE
AVGSQSGLTLDERKLAGDVSPTQIDISQFGSFKEDTKMSISEGTVSDKSATPVDEGVAED
TYSHMEGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTF
QETEMSPSKEECPRPMSISPPDFSPKTDKSRTPLQEHKS-EQSSMSIEFGQESPEHSLAM
DFSRQSPDHPTAGMSVLHISENGPTEVDYSP-DMQDSSFSHKIPPAEEP-SYAQDNDLSE
LISVSQVEASPSTSSAHTPSQIASPLQEDALSDVIPPRDISLYSSLASEKVQSLEGEKLS
PKSDISPLTPRESSPLYSPSFSESTSAFKENTSTCRSPSPSAAMSTSSAEPYGFRSSMLF
DSMQHHLSLNSHLPSSGTEK---EP-EKMSDDFSYTYQKSEQTTKSPDE-EDYTYETCEK
KTRSPELGSYSYEKTERATRSPHDSGYAFETFEKTFKAPEDDDFACKTTEKTRRSPEEGG
YSFEMSEKTTRTTEVGGYTYEKMERT-TRLLDDISNGYDESEDGSQTPGDSTYSYETMEK
ITS-FPDSESYAYETSKRTSQTPESS-TYCYETPEK

PF00414 // ENSGT00550000074593_0_Domain_15 (2257, 2289)

ITRTPQASTYSYETS---------
--------DQC---FTAE--------------KKSPTQARQDVDLCLVSSCEYKHPKTEL
SPSFINPNPLEWFASEEQTQEYEKPLTQSGGGPPPPGGKQQGRQCDETPPTSVSESAPSQ
TDSDVPPETEECPSITADANIDSEDESETIPTDKTVTYKHIDPPPVPMQDRSPSPRHPDV
SMVDPEALALEQNLGKALKKDLKEKTKTKKPGTKSKSLSPVKKADGKSKQSAASLKPAGL
KESLEKVSRTTSPKKKESAEKTTKTS-TTPEVK--ASRLEEKDKETKNATNTSTSKSAKA
ATA----GPGPTKTAKASAVPPGPPVYLDLVYIPNHSNSKNVDVEFFKRVRSSYYVVSGN
DPAAEEPSRAVLDSLLEGKSQWGSNMQVTLIPTHDSEVMREWYQETHEKQQDLNIMVLAS
SSTVVMQDESFPACKIEL

------------------------------------------------------------
------------------------------------------------------------
-----MATVVVEATEPEPSGSIGNPAASTSPSLSHRFLDSKFYLLVVVGETVTEEHLRRA
IGNIE-LGIRSWDTNLIECNLDQELKLFVSRHSARFSPEVP-----------GQKILHHR
SDVLETVVLINPSDEAVSTEVRLMITDAARHKLLVLTGQCFENTGELILQSGSFSFQNFI
EIFTDQEIGELLSTTHPANKASLTLFCPEEGDWKNSNLDRHNLQDFINIKLNSASILPEM
EGLSEFTEYLSESVEVPSPFDILEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFNML
INGGSERKSCFWKLIRHLDRVDSILLTHIGDDNLPGINSMLQRKIAELEEERSQGSTSNS
DWMKNLISPDLGVVFLNVPENLKDPEPNIKMKRSIEEACFTLQYLNKLSMKPEPLFRSVG
NTIEPVILFQKMGVGKLEMYVLNPVKSSKEMQYFMQQW---T-GTN-KDKAE-LILPN-G
QEVD-IPISYL-TSVSS-LIVWHPANPAEKIIRVLFPGNSTQYNILEGLEKLKHLDFLKQ
PLATQKDLTGQVPTPP-VKQVKLKQRADSRESLKPATKPLAS-KSVRKESKEETPEVTKA
SQ-VEKTPKVESKEKVLVKKDK------PVKTESKPSVTEKEVSSK--EEQSPVKAEVAE
K---QATESKPKVTKDKVVKKEIKTKLEEKKE----EKPKKEVVKKEDKTPLKKDEKPRK
EEVKKEIKKEIKKEERKELKKEVKKETPLKDAKKEVKKEEKKEVKKEEKEPKKEIKKISK
DIKK-STPLSDTKKPSALKPKVAKKEESTKKEPL-AAGKLKDKGKVKVIKKEGKTTEAAA
TAVG-TAATTAAAVAAAGIAA-SGPVKELEAERSLMSSPEDLTKDFEELKAEEIDVAKDI
KPQLELIEDEEKLKETQPGEAYVIQKETEVSKGSAESPDEGITTTEGEGECEQTPEELEP
VEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEDNASGSASKHSPT--
--------EDDESAKAEADVHL----K-EKRESVVSGDDRAEEDMDDVLEKGEAEQSEEE
G--EE-EDKAEDAREEGYEPDK-IEAEDYVMAVADKAAE-AGVTEEQY-GFLGTSAKQPG
IQSPSREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPM
DEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYSQEYSKPA----VASFNGLSDGS
KTDATDGKDYNASASTISPPSSMEEDKFSKSALRDAYCSEEKELKASAELDI----KD--
ASDERLSPAKSPSLSPSPPSPIEKTPLGERSVNFSLTPNEIKVSAEGEARS-VSPGVTQA
VVEEHCASPEEKTLEVVSPSQSVTGSAGHTPYYQSPTDEKSSHLPTEVTEKPQAVPVSFE
FSE-AKDENERASLSPMDEPVPDSESPVEKVLSPLRSPPLLGSESPYEDFLSADSKVLGR
RSESPFEGKNGKQGFPDRESPVSDLTSTGLYQDKQEEK-NTGFIPIKEDFGSEKKTSDVE
TMSSQSALALDERKLG-DVSPTQIDVSQFGSFKEDTKMSISEGTVSDKSATPVDEGVAED
TYSHMEGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTF
QETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQDHRS-EQSSMSIEFGQESPEHSLAM
DFSRQSPDHPTLGASVLHITENGPTEVDYSPSDIQDSSLSHKIPPMEEP-SYTQDNDLSE
LISVSQVEASPSTSSAHTPSQIASPLQEDTLSDVVPPREMSLYASLASEKVQSLEGEKLS
PKSDISPLTPRESSPLYSPGFSDSPSTAKETAAAHQASS-SPPIDAATAEPYGFRSSMLF
DTMQHHLALNRDLTTSSMEK---DSGGKTPGDFSYAYQKPENATGSPDE-EDYDYESQEK

PF00414 // ENSGT00550000074593_0_Domain_5 (2101, 2117)

TIRTHDVGGYYYEKTE

ENSGT00550000074593_0_Linker_5_6 (2117, 2118)

R

PF00414 // ENSGT00550000074593_0_Domain_6 (2118, 2134)

TIKSPCDSGYSYETIEKTTKTPEDGGYTCEITEK

PF00414 // ENSGT00550000074593_0_Domain_9 (2152, 2168)

TTRTPEEGG
YSYEISE

ENSGT00550000074593_0_Linker_9_10 (2168, 2169)

K

PF00414 // ENSGT00550000074593_0_Domain_10 (2169, 2185)

TTRTPEVSGYTYEKTERS-RRLLDDISNGYDDTEDGGHTLGDCSYSYETTEK
ITS-FPESESYSYETSTK

PF00414 // ENSGT00550000074593_0_Domain_14 (2239, 2256)

TTRSPDTS-AYCYETME

ENSGT00550000074593_0_Linker_14_15 (2256, 2257)

K

PF00414 // ENSGT00550000074593_0_Domain_15 (2257, 2290)

ITKTPQASTYSYETS---------
--------DRC---YTTE--------------KKSPSEARQDVDLCLVSSCEFKHPKTEL
SPSFINPNPLEWFAGEEPTEESEKPLTQSGGAPPPSGGKQQGRQCDETPPTSVSESAPSQ
TDSDVPPETEECPSITADANIDSEDESETIPTDKTVTYKHMDPPPAPMQDRSPSPRHPDV
SMVDPDALAIDQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKGDGKSKPLAASPKPGAL
KESSDKASRVASPKKKESVEKATKTT-TTPEVK--ATRGEEKDKETKNAANASASKSVKT
ATA----GPGTTKTAKSSTVPPGLPVYLDLCYIPNHSNSKNVDVEFFKRVRSSYYVVSGN
DPAAEEPSRAVLDALLEGKAQWGSNMQVTLIPTHDSEVMREWYQETHEKQQDLNIMVLAS
SSTVVMQDESFPACKIEL

------------------------------------------------------------
------------------------------------------------------------
-----MATVVVEATEPEPSGSIANPAASTSPSLSHRFLDSKFYLLVVVGEIVTEEHLRRA
IGNIE-LGIRSWDTNLIECNLDQELKLFVSRHSARFSPEVP-----------GQKILHHR
SDVLETVVLINPSDEAVSTEVRLMITDAARHKLLVLTGQCFENTGELILQSGSFSFQNFI
EIFTDQEIGELLSTTHPANKASLTLFCPEEGDWKNSNLDRHNLQDFINIKLNSASILPEM
EGLSEFTEYLSESVEVPSPFDILEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFNML
INGGSERKSCFWKLIRHLDRVDSILLTHIGDDNLPGINSMLQRKIAELEEEQSQGSTTNS
DWMKNLISPDLGVVFLNVPENLKNPEPNIKMKRSIEEACFTLQYLNKLSMKPEPLFRSVG
NTIDPVILFQKMGVGKLEMYVLNPVKSSKEMQYFMQQW---T-GTN-KDKAE-FILPN-G
QEVD-LPISYL-TSVSS-LIVWHPANPAEKIIRVLFPGNSTQYNILEGLEKLKHLDFLKQ
PLATQKDLTGQVPTPV-VKQTKLKQRADSRESLKPAAKPLPS-KSVRKESKEETPEVTKV
NH-VEKPPKVESKEKVTAKKDK------PVKTETKPSVTEKEVPSK--EEPSPVKAEVAE
K---QATDVKPKAAKEKTVKKETKVKPEDKKEE--KEKPKKEVAKKEDKTPIKKEEKPKK
EEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKEVKKEEKEPKKEIKKLPK
DAKKSSTPLSEAKKPAALKPKVPKKEESVKKDSV-AAGKPKEKGKIKVIKKEGKAAEAVA
A-AV-GTGATTAAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVTKDI
KPQLELIEDEEKLKETEPVEAYVIQKEREVTKGPAESPDEGITTTEGEGECEQTPEELEP
VEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEEHVCVSASKHSPT--
-------ED-EESAKAEADAYI----R-EKRESVASGDDRAEEDMDEAIEKGEAEQSEEE
A--D-EEDKAEDAREEEYEPEK-MEAEDYVMAVVDKAAE-AGGAEEQY-GFLTTPTKQPG
AQSPGREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPM
DEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYSQEYSKPAD---VTPLNGFSEGS
KTDATDGKDYNASASTISPPSSMEEDKFSRSALRDAYCSEVK---ASTTLDIKDTISA--
VSSEKVSPSKSPSLSPSPPSPLEKTPLGERSVNFSLTPNEIKVSAEAEVAP-VSPEVTQE
VVEEHCASPEDKTLEVVSPSQSVTGSAGHTPYYQSPTDEKSSHLPTEVIEKPPAVPVSFE
FSD-AKDENERASVSPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYESFLSADDKASGR
GAKSPFEEKSGKQGSPDQVSPVSEMTSTSLYQDKQEGK-STDFAPIKEDFGQEKKTDDVE
AMSSQPALALDERKLG-DVSPTQIDVSQFGSFKEDTKMSISEGTVSDKSATPVDEGVAED
TYSHMEGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTF
QETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQDHRS-EQSSMSIEFGQESPEQSLAM
DFSRQSPDHPTVGAGVLHITENGPTEVDYSPSDMQDSSLSHKIPPMEEP-SYTQDNDLSE
LISVSQVEASPSTSSAHTPSQIASPLQEDTLSDVAPPRDMSLYASLTSEKVQSLEGEKLS
PKSDISPLTPRESSPLYSPTFSDSTSAVKEKTATCHSSS-SPPIDAASAEPYGFRASVLF
DTMQHHLALNRDLSTPGLEK---DSGGKTPGDFSYAYQKPEETTRSPDE-EDYDYESYEK

PF00414 // ENSGT00550000074593_0_Domain_5 (2101, 2117)

TTRTSDVGGYYYEKIERTTKSPSDSGYSYETIGK

PF00414 // ENSGT00550000074593_0_Domain_7 (2135, 2151)

TTKTPEDGDYSYEIIEKTTRTPEEGG
YSYDISEKTTSPPEVSGYSYEKTERS-RRLLDDISNGYDDSEDG

PF00414 // ENSGT00550000074593_0_Domain_12 (2205, 2220)

GHTLGDPSYSYETTEK
ITS-FPESEGYSYETSTK

PF00414 // ENSGT00550000074593_0_Domain_14 (2239, 2256)

TTRTPDTS-TYCYETAE

ENSGT00550000074593_0_Linker_14_15 (2256, 2257)

K

PF00414 // ENSGT00550000074593_0_Domain_15 (2257, 2289)

IARTPQASTYSYETS---------
--------DLC---YTAE--------------KKSPSEARQDVDLCLVSSCEYKHPKTEL
SPSFINPNPLEWFASEEPTEESEKPLTQSGGAPPPPGGKQQGRQCDETPPTSVSESAPSQ
TDSDVPPETEECPSITADANIDSEDESETIPTDKTVTYKHMDPPPAPVQDRSPSPRHPDV
SMVDPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKSDGKSKPLAASPKPAGL
KESSDKVSRVASPKKKESVEKAAKPT-TTPEVK--AARGEEKDKETKNAANASASKSAKT
AT---A-GPGTTKTTKSSAVPPGLPVYLDLCYIPNHSNSKNVDVEFFKRVRSSYYVVSGN
DPAAEEPSRAVLDALLEGKAQWGSNMQVTLIPTHDSEVMREWYQETHEKQQDLNIMVLAS
SSTVVMQDESFPACKIEL

------------------------------------------------------------
------------------------------------------------------------
-----MATVVVEATEPEPSGSIGNPAATTSPSLSHRFLDSKFYLLVVVGETVTEEHLRRA
IGNIE-LGIRSWDTNLIECNLDQELKLFVSRHSARFSPEVP-----------GQKILHHR
SDVLETVVLINPSDEAVSTEVRLMITDAARHKLLVLTGQCFENTGELILQSGSFSFQNFI
EIFTDQEIGELLSTTHPANKASLTLFCPEEGDWKNSNLDRHNLQDFINIKLNSASILPEM
EGLSEFTEYLSESVEVPSPFDILEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFNML
INGGSERKSCFWKLIRHLDRVDSILLTHIGDDNLPGINSMLQRKIAELEEERSQGSTSNS
DWMKNLISPDLGVVFLNVPENLKNPEPNIKMKRSTEEACFTLQYLNKLSMKPEPLFRSVG
NAIEPVILFQKMGVGKLEMYVLNPVKSSKEMQYFMQQW---T-GTN-KDKAE-LILPN-G
QEVD-IPISYL-TSVSS-LIVWHPANPAEKIIRVLFPGNSTQYNILEGLEKLKHLDFLKQ
PLATQKDLTGQVSTPP-VKQVKLKQRADSRESLKPATKPLSS-KSVRKESKEEAPEATKA
SQ-VEKTPKVESKEKVIVKKDK------PGKVESKPSVTEKEVPSK--EEQSPVKAEVAE
K---AATESKPKVTKDKVVKKEIKTKPEEKKE----EKPKKEVAKKEDKTPLKKDEKPKK
EEAKKEIKKEIKKEEKKELKKEVKKETPLKDAKKEVKKDEKKEVKKEEKEPKKEIKKISK
DIKK-STPLSDTKKPAALKPKVAKKEEPTKKEPI-AAGKLKDKGKVKVIKKEGKTTEAAA
TAVG-TAAVAAA-----AGVAASGPAKELEAERSLMSSPEDLTKDFEELKAEEIDVAKDI
KPQLELIEDEEKLKETEPGEAYVIQKETEVSKGSAESPDEGITTTEGEGECEQTPEELEP
VEKQGVDDIEKFEDEGAGFEESSEAGDYEEKAETEEAEEPEEDGEDNVSGSASKHSPT--
--------EDEEIAKAEADVHI----K-EKRESVASGDDRAEEDMDEALEKGEAEQSEEE
G--EEEEDKAEDAREEDHEPDK-TEAEDYVMAVVDKAAE-AGVTEDQY-GFLGTPAKQPG
VQSPSREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPM
DEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYSQEYSKPV----VASFNGLSDGS
KTDATDGRDYNASASTISPPSSMEEDKFSKSALRDAYRPEETDVKTGAELDI----KD--
VSDERLSPAKSPSLSPSPPSPIEKTPLGERSVNFSLTPNEIKASAEGEATAVVSPGVTQA
VVEEHCASPEEKTLEVVSPSQSVTGSAGHTPYYQSPTDEKSSHLPTEVTEKPQAVPVSFE
FTE-AKDENERSSISPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYEDFLSADDKALGR
RSESPFEGKNGKQGFSDKESPVSDLTS-DLYQDKQEEK-SAGFIPIKEDFSPEKKASDAE
IMSSQSALALDERKLGGDGSPTQVDVSQFGSFKEDTKMSISEGTVSDKSATPVDEGVAED
TYSHMEGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTF
QETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQDHRS-EQSSMSIEFGQESPEHSLAM
DFSRQSPDHPTVGAGMLHITENGPTEVDYSPSDIQDSSLSHKIPPTEEP-SYTQDNDLSE
LISVSQVEASPSTSSAHTPSQIASPLQEDTLSDVVPPRDMSLYASLASEKVQSLEGEKLS
PKSDISPLTPRESSPTYSPGFSDSTSGAKESTAAYQTSS-SPPIDAAAAEPYGFRSSMLF
DTMQHHLALSRDLTTSSVEK---DNGGKTPGDFNYAYQKPESTTESPDE-EDYDYESHEK

PF00414 // ENSGT00550000074593_0_Domain_5 (2101, 2117)

TIQAHDVGGYYYEKTE

ENSGT00550000074593_0_Linker_5_6 (2117, 2118)

R

PF00414 // ENSGT00550000074593_0_Domain_6 (2118, 2134)

TIKSPCDSGYSYETIEKTTKTPEDGGYSCEITEK

PF00414 // ENSGT00550000074593_0_Domain_9 (2152, 2168)

TTRTPEEGG
YSYEISE

ENSGT00550000074593_0_Linker_9_10 (2168, 2169)

K

PF00414 // ENSGT00550000074593_0_Domain_10 (2169, 2185)

TTRTPEVSGYTYEKTERS-RRLLDDISNGYDDTEDGGHTLGDCSYSYETTEK
ITS-FPESESYSYETTTK

PF00414 // ENSGT00550000074593_0_Domain_14 (2239, 2256)

TTRSPDTS-AYCYETME

ENSGT00550000074593_0_Linker_14_15 (2256, 2257)

K

PF00414 // ENSGT00550000074593_0_Domain_15 (2257, 2290)

ITKTPQASTYSYETS---------
--------DRC---YTPE--------------RKSPSEARQDVDLCLVSSCEFKHPKTEL
SPSFINPNPLEWFAGEEPTEESEKPLTQSGGAPPPSGGKQQGRQCDETPPTSVSESAPSQ
TDSDVPPETEECPSITADANIDSEDESETIPTDKTVTYKHMDPPPAPMQDRSPSPRHPDV
SMVDPEALAIEQNLGKALKKDLKEKAKTKKPGTKTKSSSPVKKGDGKSKPSAASPKPGAL
KESSDKVSRVASPKKKESVEKAMKTT-TTPEVK--ATRGEEKDKETKNAANASASKSVKT
ATA----GPGTTKTAKSSTVPPGLPVYLDLCYIPNHSNSKNVDVEFFKRVRSSYYVVSGN
DPAAEEPSRAVLDALLEGKAQWGSNMQVTLIPTHDSEVMREWYQETHEKQQDLNIMVLAS
SSTVVMQDESFPACKIEL

------------------------------------------------------------
------------------------------------------------------------
-----MATVVVEATEPEPSGSIANPAASTSPSLSHRFLDSKFYLLVVVGEIVTEEHLRRA
IGNIE-LGIRSWDTNLIECNLDQELKLFVSRHSARFSPDVPEMKKNYSRIIKGQKILHHR
SDVLETVVLINPSDEAVSTEVRLMITDAARHKLLVLTGQCFENTGELILQSGSFSFQNFI
EIFTDQEIGELLSTTHPANKASLTLFCPEEGDWKNSNLDRHNLQDFINIKLNSASILPEM
EGLSEFTEYLSESVEVPSPFDILEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFNML
INGGSERKSCFWKLIRHLDRVDSILLTHIGDDNLPGINSMLQRKIAELEEEQSQGSTTNS
DWMKNLISPDLGVVFLNVPENLKNPEPNIKMKRSLEEACFTLQYLSKLSMKPEPLFRSVG
NTIDPVILFQKMGVGKLEMYVLNPVKSSKEMQYFMQQW---T-GTS-KDKAE-LILPN-G
QEVD-IPITYL-TSVSS-LIVWHPANPAEKIIRVLFPGNSTQYNILEGLEKLKHLDFLKQ
PLATQKDLTGQVPTSA-VKQVKLKQRADSRESLKPATKPLPS-KSVRKESKEETSDVTKA
NH-VEK-PKVESKEKVTVKKDK------PIKTETKPPVTEKEAPSK--DEPSPVKAEVAE
K---QATDVKPKVTKEKIVKKETKVKSEEKKEE--KEKPKKEVAKKEDKTPIKKEEKPKK
EEVKKEVKKEIKKEEKKELKKEVKKETPLKEVKKEVKKDEKKEIKKEEKEPKKEIKKLPK
DSKKLSTPLSEAKKPAALKPKVAKKEDSVKKDSV-AAGKPKEKGKIKVIKKEGKTTEAAA
-AAV-GTVATAAAMVAAAGIAATGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVTKDI
KPQLELIEDQEKLKETEPVEAYVI-------KGPAESPDEGITTTEGEGECEQTPEELEP
VEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEENVHVSTSKHSLI--
-------E-DEESAKAEADVHI----R-EKRESVASGDDRAEEDMDEAVEKGEAEQSEDE
R----EEDKAEDAREEEYEPKK-IEAEDYVMAVVDKAAE-ASGAEDQY-GFLTTPAKQVG
APSPGREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPM
DEMSTPRDVMSDETNNEETESPSQEFVNITQYESSLYSQEYSKPA----VTTLNGLSEGS
KTDATDGKDYNASASTISPPSSMEEDKFSKSALRDAYYSEVKEVKASAMLEIKDTI----
-SDEKLSPSKSPSLSPSPPSPIEKTPLGERSVNFSLMPNEIKVSTEADVVS-ASPEVTQE
VVEEHCASPEDKTLEVVSPSQSVTGSAGHTPYYQSPTDEKSSHLPTEVIEKPPALPVSFE
FSD-AKDENERASISPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYESFLSADGKASGR
CTESPFEEKIGKQSFPDQISPVSEITSTGLYQDKQEGK-STDFIPIKEDFGQGKKTDDAE
SVSSQPALALDERKLGGDVSPTQIDVSQFGSFKEDTKMSISEGTVSDKSATPVDEGVAED
TYSHMEGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTF
QETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQEHRS-EQSSMSIEFGQESPEHSLAM
DFSRQSPDHPAVGASILHITENGPTEVDYSPSDMQDSSLSHKIPPMEEP-SYTQDNDLSE
LISVSQVEASPSTSSAHTPSQIASPLQEDTLSDVAPPRDISLYASLTSEKVQSLEGEKLS
PKSDISPLTPRESSPLYSPSFSDSTSAVKENIAACHPSS-SPPIDAASAEPYGFRASMLF
DTMQHHLALNRDLTTSGMEK---DSGGKTPGDFSYAYQTHEKTTRSPDE-EDYDYASYEK

PF00414 // ENSGT00550000074593_0_Domain_5 (2101, 2117)

TSRPPDVGGYYYEKTE

ENSGT00550000074593_0_Linker_5_6 (2117, 2118)

R

PF00414 // ENSGT00550000074593_0_Domain_6 (2118, 2132)

TTKSPGDSDYSYETIVKTTKTPEHGGYACEITEK

PF00414 // ENSGT00550000074593_0_Domain_9 (2152, 2168)

TTRTPEEGG
YSYEISE

ENSGT00550000074593_0_Linker_9_10 (2168, 2169)

K

PF00414 // ENSGT00550000074593_0_Domain_10 (2169, 2185)

TTRTPDVSGYSYEKTERS-RRLLDDISNGYDDSEDG

PF00414 // ENSGT00550000074593_0_Domain_12 (2205, 2220)

GHTLGDSSYSYETTEK
ISS-FPESDSYSYETSTK

PF00414 // ENSGT00550000074593_0_Domain_14 (2239, 2256)

TTRSPDTS-TYCYETTE

ENSGT00550000074593_0_Linker_14_15 (2256, 2257)

K

PF00414 // ENSGT00550000074593_0_Domain_15 (2257, 2290)

ITRTPQASTYSYETS---------
--------DRC---YATE--------------KKSPSEARQDVDLCLVSSCEYKHPKTEL
SPSFINPNPLEWFASEEPTEESEKPLTQSGGAPPPPGGKQQGRQCDETPPTSVSESAPSQ
TDSDVPPETEECPSITADANIDSEDESETIPTDKTVTYKHMDPPPAPMQDRSPSPRHPDV
SMVDPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKSDGKSKPLAASPKPAGL
KESSDKVSRVASPKKKESVEKATKTT-TTPEVK--AARGEEKDKETKNAANASTSKSVKT
ATA----GPGTTKTVKSPAVPPGLPVYLDLCYIPNHSNSKNVDVEFFKRVRSSYYVVSGN
DPAAEEPSRAVLDALLEGKAQWGSNMQVTLIPTHDSEVMREWYQETHEKQQDLNIMVLAS
SSTVVMQDESFPACKIEL

------------------------------------------------------------
------------------------------------------------------------
-----MATVVVEATEPEPSGSIANPAASTSPSLSHRFLDSKFYLLVVVGEIVTEEHLRRA
IGNIE-LGIRSWDTNLIECNLDQELKLFVSRHSARFSPEVP-----------XXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXIEKLLSTTHPANKASLTLFCPEEGDWKNSNLDRHNLQDFINIKLNSASILPEM
EGLSEFTEYLSESVEVPSPFDILEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFNML
INGGSERKSCFWKLIRHLDRVDSILLTHIGDDNLPGINSMLQRKIAELEEEQSQGSTTNS
DWMKNLISPDLGVVFLNVPENLKNPEPNIKMKRSIEEACFTLQYLNKLSMKPEPLFRSVG
NTIDPVILFQKMGVGKLEMYVLNPVKSSKEMQYFLQQW---T-GTN-KDKAE-LILPN-G
QEVD-IPISYL-TSVSS-LIVWHPANPAE-IIRVLFPGNSTQYNILEGLEKLKHLDFLKQ
PLATQKDLTGQVPTGT-VKQVKLKQRADSRESLKPATKPLSS-KTVRKESKEETTDVTKT
NH-VEKPPKVESKEKVTVKKDK------PVKTETKPPVTEKEVTSK--EEQPPIKAEVAE
K---QATDVKPKVTKEKTVKKEIKAKSEEKKEE--KEKPKKEVAKKEDKTPIKKEEKPKK
EEVKKEVKKEIKKDEKKELKKEVKKETPLKETKKEVKKXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
X-XX-XXXXXXX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--
--------XXXXXXXXXXXXXX----X-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XX---XXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX----XXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXRDAYCSE---VKACATLEIKDTTSP--
LTDEKRSPSKSPSLSPSPPSPIEKTPLGERSVNFSLTPNEIKVSAEAETVS-ASPEVTQE
VVEEHCASPEDKTLEVVSPSQSATGSAGHTPYYQSPTDEKSSHLPTEVIEKPPAAPVSFE
FSDAKDENER-ASISPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYESFLSAGDKDPS-
--ESLFEGKNGKKGFPDQTSPVSEITSTGLYQDKQEDK-STDFIPIKEDFGQEKKTDDIE
TISSQPALALDERKLGGDVSPTQIDVSQFGSFKEDTKMSISEGTVSDKSATPVDEGVAED
TYSHMEGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTF
QETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQDHRS-EQSSMSIEFGQESPEHSLAM
DFSRQSPDHPTVGASMLHITENGPTEVDYSPSDMQDSSLSHKIPPMEEP-SYTQDNDLSE
LISVSQVEASPSTSSAHTPSQIASPLQEDTLSDVAPPRDISLYASLASEKVQSVEGEKLS
PKSDISPLTPRESSPLYSPSFSDSTSAVKENIA-ASHTSSSPPTDAASAEPYGFRASMLF
DTMQHHLALNRDLTSSGMEK---DSGGKTPGDFSYAYQKPEK

PF00414 // ENSGT00550000074593_0_Domain_4 (2083, 2100)

ATRSPDE-EDYDYESYE

ENSGT00550000074593_0_Linker_4_5 (2100, 2101)

K

PF00414 // ENSGT00550000074593_0_Domain_5 (2101, 2117)

TTRTPDAGGYYYEKTD

ENSGT00550000074593_0_Linker_5_6 (2117, 2118)

R

PF00414 // ENSGT00550000074593_0_Domain_6 (2118, 2134)

TTKSPCDSGYSYEMIG

ENSGT00550000074593_0_Linker_6_7 (2134, 2135)

K

PF00414 // ENSGT00550000074593_0_Domain_7 (2135, 2151)

TTKTPEDGGYAYEITE

ENSGT00550000074593_0_Linker_7_9 (2151, 2152)

K

PF00414 // ENSGT00550000074593_0_Domain_9 (2152, 2167)

TTRSPEESG
YSYEMS

ENSGT00550000074593_0_Linker_9_10 (2167, 2171)

E--T

PF00414 // ENSGT00550000074593_0_Domain_10 (2171, 2185)

RTPEVSGYSYEKTERS-RRLLDDISNGYDDTED

PF00414 // ENSGT00550000074593_0_Domain_12 (2204, 2220)

GVHTLGDSSYSYETTE

ENSGT00550000074593_0_Linker_12_13 (2220, 2221)

K

PF00414 // ENSGT00550000074593_0_Domain_13 (2221, 2238)

ITS-FPESESYSYETST

ENSGT00550000074593_0_Linker_13_14 (2238, 2239)

K

PF00414 // ENSGT00550000074593_0_Domain_14 (2239, 2256)

TTRTPDTS-TYCYETTE

ENSGT00550000074593_0_Linker_14_15 (2256, 2257)

N

PF00414 // ENSGT00550000074593_0_Domain_15 (2257, 2290)

ITRTPQTSTYSYEAS---------
--------DRC---YTAE--------------KKSPSEARQDVDLCLVSSCEYKHPKTEL
SPSFINPNPLEWFASEDPTDESEKPLTQSGGAPPPPGGKQQGRQCDETPPTSVSESAPSQ
TDSDVPPETEECPSITADANIDSEDESETIPTDKTVTYKHMDPPPVPMQDRSPSPRHPDV
SMVDPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKGDGKSKPLAASPKPVGL
KESSDXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXX
XX----XXPGATKTTKSSAVPPGLPVYLDLCYIPNHSNSKNVDVEFFKRVRSSYYVVSGN
DPAAEEPSRAVLDALLEGKAQWGSNMQVTLIPTHDSEVMREWYQETHEKQQDLNIMVLAS
SSTVVMQDESFPACKIEL

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------TNLIECNLDQELKLFVSRHSARFSPEVP-----------GQKILHHR
SDVLETVVLINPSDEAVSTEVRLMITDAARHKLLVLTGQCFENTGELILQSGSFSFQNFI
EIFTDQEIGELLSTTHPANKASLTLFCPEEGDWKNSNLDRHNLQDFINIKLNSASILPEM
EGLSEFTEYLSESVEVPSPFDILEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFNML
INGGSERKSCFWKLIRHLDRVDSILLTHIGDDNLPGINSMLQRKIAELEEEQSQGSTTNS
DWMKNLISPDLGVVFLNVPENLKNPEPNIKMKRSIEEACFTLQYLNKLSMKPEPLFRSVG
NTIEPVILFQKMGVGKLEMYVLNPVKSSKEMQYFLQQW---T-GTN-KDKAE-LILPS-G
QEVD-IPISYL-TSVSS-LIVWHPANAAEKIIRVLFPGNSTQYNILEGLEKLKHLDFLKQ
PLATQKDLTGQVPTPTTAKQVKLKQRADSRESLKPAAKSLPT-KSVRKESKEETPDVTKA
NQ-VEKPPKVESKEKVIVKKDK------PIKTETK-PVTEKEVASK--EEQPSAKAEVAE
K---QGTDVKPKIAKEKVVKKETKPKLEEKKEE--KEKPKKEVAKKEEKTPVKKEEKLKK
EELKKEVKKEIKKEEKKELKKEVKKETPLKDAKKEVK----KEIKKDEKEPKKEIKKLSK
DSKKPTTPLSEAKKPAALKPKVPKKEETVKKE-SVAAGKPKEKGKIKVIKKESKTSEAVA
I-GT-VVTTAAA--VAAAGIAATGPAKELEAERSLMSSPEDLTKDFEELKAEEIDVAKDI
KPQLELIEDEEKVKETEPVEAYVIQKETEVIKGSAESPDEGITTTEGEGECEQTPEELEP
VEKQGVDDIEKYEDEGAGFEESSETGDYEEKAETEEAEEPEEDSEENVCVSTSKHSPI--
--------EDDESAKAEADVHI----K-EKRESVASGDDRAEEDMDEAVGKGEAELSEEE
GE---EEDKAEDAREEEYEPEK-AEAEDYVMAVVDK-ATEASGTEDQY-GFLATSAKQPG
AQSPGRGPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPM
DEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYSQEYTKPG----VIPFNGLSDGS
KTDATDGKDYSVSASTISPPSSMEEDKFTRSALRDAYCSEEKEVKASAALEIQDKTSA--
VSGERLSPAKSPSLSPSPPSPVEKTPLGERSVNFSLTPNEIQVSTEAEAVS-VSPEVTQE
VVEEHCASPEEKTLEVVSPSQSVTGSAGHTPYYQSPTDEKSSHLPAEVIEKPQAVPVSFE
FSDAKDENER-ASISPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYESFLSVDDKAPSR
GSESPFEGKNGKQSFPDEISPVSEMTSTGLYQDRQEGK-STNFIPIKEDFSLEKKTDDME
TMSSHATLALDERKLG-DVSPTQIDAIQFGSFKEDTKMSISEGTVSDKSATPVDEGVAED
TYSHMEGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTF
QETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQDHRS-EQSSMSIEFGQESPEHSLAM
DFSRQSPDHPTVGASVLHITENGPTEVDYSPSDLQDSSLSHKIPPTEEP-SYTQDNDLSE
LISVSQVEASPSTSSAHTPSQIASPLQEDTLSDVAPPRDMSLYASLTSEKVQSLEREKLS
PKSDISPLTPRESSPLYSPGFSDSTSAVKENAA-ACHTS-SPPVDAASSEPYGFRASMLF
DTVQHHLTLNRDLTTSRVED---SGG-KTPGDFSYAYQKPEKATRSPDEEEDYDYESYEK
SS

PF00414 // ENSGT00550000074593_0_Domain_5 (2103, 2117)

RTPDVGSYYYEKTE

ENSGT00550000074593_0_Linker_5_6 (2117, 2120)

RTM

PF00414 // ENSGT00550000074593_0_Domain_6 (2120, 2134)

KSPCDSGYSYETIEK-TKTPEDGGYACEITEK

PF00414 // ENSGT00550000074593_0_Domain_9 (2152, 2168)

TTRTPEEGG
YSYEISE

ENSGT00550000074593_0_Linker_9_10 (2168, 2169)

K

PF00414 // ENSGT00550000074593_0_Domain_10 (2169, 2185)

TIRTPDVSGYSYEVTERS-RRLLDDISNGYDDSEDG

PF00414 // ENSGT00550000074593_0_Domain_12 (2205, 2220)

GHTLGDSSYSYETTEK
ITS-FPESESYSYETSMK

PF00414 // ENSGT00550000074593_0_Domain_14 (2239, 2256)

TTRSPDSS-TYCYETME

ENSGT00550000074593_0_Linker_14_15 (2256, 2257)

K

PF00414 // ENSGT00550000074593_0_Domain_15 (2257, 2290)

ITKTPQTSTYSYETS---------
--------DRC---YSAE--------------KKSPSEARQEVDLCLVSSCEYKHPKTEL
SPSFINPNPLEWFASEEPTEESEKPLTQLGGAPPPPGGKQQGRQCDETPPTSVSESAPSQ
TDSDVPPETEECPSITADANIDSEDESETIPTDKTVTYKHMDPPPAPMQDRSPSPRHPDV
TMVDPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKGDGKSKPLAASPKPGPL
KEPSDKVSRVASPKKKESVEKATKST-TTPEVK--AARGEEKDKETKNAAN--VSKSVKT
TT----PGLGTTKTAKSSTVPPGLPVYLDLCYIPNHSNSKNVDVEFFKRVRSSYYVVSGN
DPAAEEPSRAVLDALLEGKAQWGSNMQVTLIPTHDSEVMREWYQETHEKQQDLNIMVLAS
SSTVVMQDESFPACKIEL

------------------------------------------------------------
------------------------------------------------------------
-----MATVVVEAAEPELSGSIANPAASTSPSLSHRFLDSKFYLLVVVGEIVTEEHLRRA
IGNIE-LGIRSWDTNLIECNLDQELKLFVSRHSARFSPEVP-----------GQKILHHR
SDVLETVVLINPSDEAVSTEVRLMITDAARHKLLVLTGQCFENTGELILQSGSFSFQNFI
EIFTDQEIGELLSTTHPANKASLTLFCPEEGDWKNSNLDRHNLQDFINIKLNSASILPEM
EGLSEFTEYLSESVEVPSPFDILEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFNML
INGGSERKSCFWKLIRHLDRVDSILLTHIGDDNLPGINSMLQRKIAELEEEQSQGSTTNS
DWMKNLISPDLGVVFLNVPENLKNPEPNIKMKRSIEEACFTLQYLNKLSMKPEPLFRSVG
NTIDPVILFQKMGVGKLEMYVLNPVKSSKEMQYFLQQW---T-GTN-KDKAE-FMLPN-G
QEID-IPISYL-TSVSS-LIVWHPANPAEKIIRVLFPGNSTQYNILEGLEKLKHLDFLKQ
PLATQKDLTGQVAAPA-VKQVKLKQRADSRESLKPATKPLAS-KSVRKESKEETPEVTKA
NH-VEKPPKIESKEKVTVKKDK------PVKTETKPPVTEKEVPSK--EEQPLVKAEVAE
K---QATDVKPKVAKEKVVKKETKVKSEEKKEE--KEKPKKEVAKKEDKTPIKKEEKPKK
EEVKKEVKKEIKKEEKKEPKKEVKKETPLKEAKKEVKKEDKKEMKKEEKEPKKEIKKLPK
DVKKSSTPLSEAKKPAALKPKVPKKEESAKKD-SLAAGKPKEKGKIKVIKKEGKTTEAAA
A-AI-GTVATAAAVVAAAGIAATGPAKELEAERSLMSSPEDLTKDFEELKAEEVNVAKDI
KPQLGLIEDEEKLKATEPVEAYVIQKETE-VKGSAESPDEGITTTEGEGECEQTPEELEP
VEKQGVEDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEENVCVSTSKHSLM--
--------EEEESAKAEADAHI----K-EKRESVASGDDRAEEDMDEAVEKGEAEQSEEE
ED---EEDKAEDAREEEYEPEK-AEAEDYVMAVVDKAAEAS-GAEDQY-GFLTTSTKQQG
AQSPAQEPASTIQDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPM
DEMSTPRDVMSDETNNEETESPSQEFVNITKYESLLYSQEYTKPA----VTSLNGLSEGS
KTDATDGKDYNASASTISPPSSMEEDKFSKSVLRDAYCAEEKDRK--AMLEIKDTVSA--
VSDEKLSPPKSPSLSPSPPSPLAKTPLGERSVNFSLTPNEIKVSAKTKA

PF02818 // ENSGT00550000074593_0_Domain_2 (1490, 1516)

AP-VSPEVTQE
VAEEHCASPEDKTLEVVSPSQSVTGSAGHTPYYQSPTDEKTSHLPTEIIEKSSAVPVSFE
FSEAKDENER-ASISPMDEPVPDSESPIEKVLSPLRSPPLIGSDSAYESFLSADHKAPSR
YTGSPFEGKNGKQGFPDQISPVSDMTSTGLFQDKQQGK-STDFIPIKEDFGQQKKTDNVE
TMSSQSGLALDERKLGGDVSPTQIDVSQFGSFKEDTKMSISEGTVSDKSATPVDEGVAED
TYSHMEGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTF
QETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQDHRS-EQSSMSIEFGQESPEHSLAM
DFSRQSPDHPTMGASVLHITENGPTEVDYSPSDMQDSSLSHKIAPMEEP-SYTQDNDLSE
LISVSQVEASPSTSSAHTPSQIASPLQEDTLSDVVPPRDISLYASLTSERVRNLEGETLS
PKSDISPLTPRESSPLYSPSFSDSTSAVKENIAAYDDTSAPPSMEATSTEPYGFRASMLF
DTMQRHLALNRDLTTSGVEK---DNGGKTPGDFSYAYQKPEK

PF00414 // ENSGT00550000074593_0_Domain_4 (2083, 2100)

TSSSPDK-EGYPYESYE

ENSGT00550000074593_0_Linker_4_5 (2100, 2101)

K

PF00414 // ENSGT00550000074593_0_Domain_5 (2101, 2117)

PTRTPDKGGYYYEKTE

ENSGT00550000074593_0_Linker_5_6 (2117, 2118)

R

PF00414 // ENSGT00550000074593_0_Domain_6 (2118, 2134)

TTKAPSDSGYSYETIE

ENSGT00550000074593_0_Linker_6_7 (2134, 2135)

K

PF00414 // ENSGT00550000074593_0_Domain_7 (2135, 2151)

TTKTPEDGGFAYEITE

ENSGT00550000074593_0_Linker_7_9 (2151, 2152)

K

PF00414 // ENSGT00550000074593_0_Domain_9 (2152, 2168)

TTRAPEEGG
YSYEISE

ENSGT00550000074593_0_Linker_9_10 (2168, 2169)

K

PF00414 // ENSGT00550000074593_0_Domain_10 (2169, 2185)

TTRTPELSGYSYEKTERS-SRLLDDISNGYDDSED

PF00414 // ENSGT00550000074593_0_Domain_12 (2204, 2220)

GGNTPGDSSYSYETTEK
ISS-FPESESYTYETSTK

PF00414 // ENSGT00550000074593_0_Domain_14 (2239, 2256)

TTRTPDAS-TYCYETSE

ENSGT00550000074593_0_Linker_14_15 (2256, 2257)

K

PF00414 // ENSGT00550000074593_0_Domain_15 (2257, 2290)

ITRTPQGNTYSYETS---------
--------DQC---YTTE--------------KKSPSEARQDVDLCLVSSCEYKHPKTEL
SPSFINPNPLEWFASEEPTEESERPLTQSGGAPPPPGGKPQGRQCDETPPTSVSESAPSQ
TDSDVPPETEECPSITADANIDSEDESETIPTDKTVTYKHMDPPPAPMQDRSPSPRHPDV
SMMDPEALANEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKSDGKSKPSAASPKPGGL
KESSDKVSRVASPKKKESVEKATKPT-TTPEVK--AARGEEKDKETKNAANASASKSVKT
ATA--AKGPGTTKTTKPSAVPPGPPVYLDLCYIPNHSNSKNVDVEFFKRVRSSYYVVSGN
DPAAEEPSRAVLDALLEGKAQWGSNMQVTLIPTHDSEVMREWYQETHEKQQDLNIMVLAS
SSTVVMQDESFPACKIEL

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------IRSWDTNLIECNLDQELKLFVSRHSARFSPEVP-----------XXXXXXXX
XXXXXXXXXXXXXXXXXXXXVRLMITDAARHKLLVLTGQCFENTGELILQSGSFSFQSFI
EIFTDQEIGELLSTTHPANKASLTLFCPEEEDWKNSNLDRHNLQDFINIKLNSASILPEM
EGLSEFTEYLSESVEVPSPFDILEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFNML
INGGSERKSCFWKLIRHLDRVDSILLTHIGDDNLPGINSMLQRKIAELEEEQSQGSTTNS
DWMKNLISPDLGVVFLNVPENLKSPEPNIKMKRSIEEACFTLQYLNKLSMKPEPLFRSVG
NTIDPVILFQKMGVGKLEMYVLNPVKSSKEMQYFMQQW---T-GTN-KDKAE-LILPS-G
QEVD-IPISYL-TSVSS-LIVWHPANPAEKIIRVLFPGNSTQYNILEGLEKLKHLDFLKQ
PLATQKDLTGQVPTPA-AKGVKLKQRADSRENLKPATKPLPN-KSVRKESIDETTEVTKA
NL-VEKPPKVESKEKVTVKKDK------PPKTEAKPSVSDKEVPSK--EDQPPVKTEVAE
K---QATDVKPKVTKEKTVKKETKLKPEEKKEE--KEKPKKEVAKKEDKTPIKKEEKPKK
EEVKKEVKKEIKKEEKKEPKKEVKKETPLKEAKKEVKKEEKKEVKKEEKEPKKEIKKISK
DVKKPSTPVSEVKKPAALKPKVPKKEEPVKKE-AVAAGKPKEKGKIKVTKKEGKTTEAAA
A-AI-GTAATAAALSVGAAIAATGPAKEL

PF00183 // ENSGT00550000074593_0_Domain_1 (990, 1015)

EAERSLMSSPEDLTKDFEELKAEEVDVARDI
KPQLELIEDEEKLKGTEPVEAYVIQKETEVIKGPAESPDEGITTTEGEGECEQTPEELEP
VEKQGVEDTEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEESMYMRTSKHSPI--
--------EDEESVKAEADVHI----K-EKRESVASGDDRAEEDMDEAVEKGEAEQSEEE
GX---XXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXQPEEFTATSGYTQSTIEISSEPTPM
DEMSTPRDVMSDETNNEETESPSQEFINITKYETSLYSQEYSKP-----VSSLNGLSDVS
KTDATDGRDYNASASTISPPSSMEEDKFSRSALRDAYCSEEKEVKVSAALEIKDT-LA--
VSDEKLSPSKSPSLSPSPPSPIEKTPLGERSVNFSLMPNEIKVSAEA-AVP-VSPEVTQE
VVEEHVASPEDKTLEVVSPSQSVTGSAGHTPYYQSPTDEKSSHLPTEVIEKPPAVPVSFE
FDDAKDDSEKPSSISPMDEPVPDSESPIEKVLSPLRNPPLIGSESAYDSFLNADGKSPDR
STGSPFEGTNGKQGFPDQTSPVSEVTSTDVFQEKQEKK-STDFIPIKEDFGEHKRTGDVE
AVSSQPGLALDERKLGGDVSPTQIDGGHFGSLKEDTKMSISERTVSYKSATPVDEGVAED
TYSHMEGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTF
QETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQDHRS-EQSSMSVEFGQESPEHSLAM
DFSRQSPDHPTVGAGMLHITENGPTEVDYSPSDLQDSSLSHKIPPTEEP-SYTQDNDLSE
LISVSQVEASPSTSSAHTPSQIASPLQEDTLSDVVPPRDISLYASLTSEKVQSLEGEALS
PKSDISPLTPRESSPLYSPSFSDSTSAVKEDAAA-RHTSSSPSVDAASAEPYGFRASVLF
DTMQHHLALDRDVTTSNLEK---DS

PF00414 // ENSGT00550000074593_0_Domain_3 (2066, 2082)

GGKTPGDFSYAYQKSEKTASSPDE---ESYEYYEK

PF00414 // ENSGT00550000074593_0_Domain_5 (2101, 2117)

TKQTPDVGDYYYEKME

ENSGT00550000074593_0_Linker_5_6 (2117, 2118)

R

PF00414 // ENSGT00550000074593_0_Domain_6 (2118, 2134)

TAKSPLDSSYSYETTE

ENSGT00550000074593_0_Linker_6_7 (2134, 2135)

K

PF00414 // ENSGT00550000074593_0_Domain_7 (2135, 2149)

TSKTPEDDGYAYEI

ENSGT00550000074593_0_Linker_7_9 (2149, 2152)

TK-

PF00414 // ENSGT00550000074593_0_Domain_9 (2152, 2168)

ATRTPEEVA
YSYEISE

ENSGT00550000074593_0_Linker_9_10 (2168, 2169)

T

PF00414 // ENSGT00550000074593_0_Domain_10 (2169, 2185)

TPRTPEVSGYSYEKTERS-RRLLDDVSNGYDDTED

PF00414 // ENSGT00550000074593_0_Domain_12 (2204, 2220)

GGHTLGDSSYSYEATEK
IAG-FAESESYSYETATK

PF00414 // ENSGT00550000074593_0_Domain_14 (2239, 2256)

TSRAPDTS-AYCYETTE

ENSGT00550000074593_0_Linker_14_15 (2256, 2257)

T

PF00414 // ENSGT00550000074593_0_Domain_15 (2257, 2290)

MARTPQASTYSYESP---------
--------DRC---XXXX--------------XXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXQQGRQCDETPPTSVSESAPSQ
TDSD-PPETEECPSITADANIDSEDESETIPTDKTVTYKHMDPPPAPMQDRSPSPRHPDV
SMVDPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKGDGKSKPSAASPKPVGL
KESSDKVSRVASPKKKESVEKATKTT-TTPEVKSA--R--GEDKETKNATNASTSKSVKT
AT----AGPGTTKTAKSSAVPPGPPVYLDLCYIPNHSNSKNVDVEFFKRVRSSYYVVSGN
DPAAEEPSRAVLDALLEGKAQWGSNMQVTLIPTHDSEVMREWYQETHEKQQDLNIMVLAS
SSTVVMQDESFPACKIEL

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------P-----------GQKILHHR
SDVLETVVLINPSDEAVSTEVRLMITDAARHKLLVLTGQCFENTGELILQSGSFSFQNFI
EIFTDQEIGELLSTTHPANKASLTLFCPEEGDWKNSNLDRHNLQDFINIKLNSACILPEM
EGLSEFTEYLSESVEVPSPFDILEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFNML
INGGSERKSCFWKLIRHLDRVDSILLTHIGDDNLPGINSMLQRKIAELEEEQSQGSTTNS
DWMKNLISPDLGVVFLNVPENLKNPEPNIKMKRSIEEACFTLQYLNKLSMKPEPLFRSVG
NTIEPVILXXXXXXXXXXXYVLNPVKSSKEMQYFLQQW---T-GTS-KDKAE-LILPS-G
QEVD-IPISYL-TSVSS-LIVWHPANPAEKIIRVLFPGNSTQYNILEGLEKLKHLDFLKQ
PLATQKDLTGQVPTPTTAKQVKLKQRADSRESLKPAAKPLPT-KSVRKESKEETPDVTKA
NQ-VEKPPKVESKEKVVVKKDK------PIKTETKPPVTEKEVASK--EEQPPAKAEVAE
K---QATDVKPKVAKEKVVKKDVKPKPEEKKED--KEKPKKEVVKKEEKTPIKKEEKLKK
EEVKKEVKKEIKKEEKKELKKEVKKETPLKEAKKEVKKEEKKEIKKEEXXXXXEIKKLPK
DSKKSTTPLSEAKKPAALKPKVSKKEEPVKKESAVAAGKPKEKGKIKVIKKEGKVSEAAA
T-GA-AATT--AAAVAAAGIVATGPAKELEAXXSLMSSPEDLTKDFEELKAEEVDVVKDI
KPQLELTEDEEKEKETEPVEAYVVQKETEVIKGPAESPDEGITTTEGEGECEQTPEELEP
VEKQGVDDIEKYEDEGAGFEESSETGDYEEKAETEEAEEPEEDSEENVCVSTSKHSPI--
--------DDEESAKAEADVHI----E-EKRGSVASGDDRAEEDMDEAVEKGEAEMSEEE
GE----EDKAEDAREEEYEPEK-AEAEDYVMAVVDKAAEA--GGTDQY-AFLATSAKQPG
AQSPGREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPM
DEMSTPRDVMSDETNNEETESPSQEFVNITKYESALYSQESAKPA----VTPFNGLSDGS
KTDATEGKDYSVSASTISPPSSMEEDKFTKSALRDAYYSEEKELKPSGTLEVQDTTSA--
VSDERLSPAKSPSLSPSPPSPIEKTPLGERSVNFSLTPNEIKVSTEVEAVS-VSPEVTRE
VVEEHCASPEEKTLEVVSPSQSVTGSAGHTPYYQSPTDEKATHLPTEVIEKPQAVPVSFE
FSDAKDENER-ASVSPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYESFLSVDDKPPSR
GSESPFEGKDGKQSLSDRVSPVSEMTSTGLYLDKH-------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------EM
DFSRQSPDHPTVGASVLHITENGPTEVDYSPSDIQDSSLSHKIPPTEEP-SYTQDNDLSE
LISVSQVEASPSTSSAHTPSQIASPLQEDTLSDVAPPRDMTLYASLTSEKVQSLEAEKLS
PKSDISPLTPRESSPSYSPGFSDSTSAVKESSAAAHHIASSPPVDPASTEPYSFRASMLL
DTMQHHLTLDRDLSTSGIED---S-GGKIPGDFSYAYQKPEKTTRSPDE-EDYDYESYGK

PF00414 // ENSGT00550000074593_0_Domain_5 (2101, 2116)

TTRTPDVGSYYYEKT

ENSGT00550000074593_0_Linker_5_6 (2116, 2120)

EGTM

PF00414 // ENSGT00550000074593_0_Domain_6 (2120, 2134)

KSPCDSGYSYETTEK-IKSPEDDGYACEITEK

PF00414 // ENSGT00550000074593_0_Domain_9 (2152, 2168)

TTRSPEESG
YSYEISEKTIRTPEVSGYSYQVTERS-RRLLDDISNGYDDSEDG

PF00414 // ENSGT00550000074593_0_Domain_12 (2205, 2220)

GHTLGDSSYSYETTEK
IPS-FPESESYSYEMSTK

PF00414 // ENSGT00550000074593_0_Domain_14 (2239, 2256)

TTRSPDSS-TYCYETME

ENSGT00550000074593_0_Linker_14_15 (2256, 2257)

K

PF00414 // ENSGT00550000074593_0_Domain_15 (2257, 2290)

ITKTPQASAYSYETS---------
--------DRC---YSAE--------------KKSPSEARQEVDLCLVSSCEYKHPKTEL
SPSFINPNPLEWFASEESTEESEKPLTQSGGAPPPPGGKQQGRQCDETPPTSVSESAPSQ
TDSDVPPETEECPSITADANIDSEDESETIPTDKTVTYKHMDPPPAPMQDRSPSPRHPDV
TMVDPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKGDGKSKPSAASPKPGPL
KEPSDKVSRVASPKKKESVEKATKPT-TTPEVK--AARGEEKDKETKNAAN--VSKSVKT
AT----AGPGTTKTS---------------------------------------------
------------------------------------------------------------
------------------

MTSASGQRLEERRQPPREDVPGGPFLLLFLLLPGS-------LPS--LHIKAAPPPRPFS
LPAPLRRALSAALGEGGGGGGARRQRRGDAGGGAETAPSEIILSPAAEERSGRSETLRPG
TAAGRMATVVVEATEPEPSGSIANPAASTSPSLSHRFLDSKFYLLVVVGEIVTEEHLRRA
IGNIE-LGIRSWDTNLIECNLDQELKLFVSRHSARFSPEVP-----------GQKILHHR
SDVLETVVLINPSDEAVSTEVRLMITDAARHKLLVLTGQCFENTGELILQSGSFSFQNFI
EIFTDQEIGELLSTTHPANKASLTLFCPEEGDWKNSNLDRHNLQDFINIKLNSASILPEM
EGLSEFTEYLSESVEVPSPFDILEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFNML
INGGSERKSCFWKLIRHLDRVDSILLTHIGDDNLPGINSMLQRKIAELEEEQSQGSTTNS
DWMKNLISPDLGVVFLNVPENLKNPEPNIKMKRSIEEACFTLQYLNKLSMRPEPLFRSVG
NTIDPVILFQKMGVGKLEMYVLNPVKSSKEMQYFMQQW---T-GTN-KDKAE-LILPN-G
QEVD-LPISYL-TSVSS-LIVWHPANPAEKIIRVLFPGNSTQYNILEGLEKLKHLDFLKQ
PLATQKDLTGQVPTPV-VKQTKLKQRADSRESLKPATKPLPS-KSVRKESKEETPEVTKV
NH-VEKPPKVESKEKVTVKKDK------PVKTETKPSVTEKEVPSK--EEPSPVKAEVAE
K---QATDVKPKAAKEKTVKKETKAKPEDKKEE--KEKPKKEVAKKEDKTPIKKEEKPKK
EEVKKEVKKEIKKEEKKEPKKEVKKETPLKEAKKEVKKEEKKEVKKEEKEPKKEIKKLPK
DAKKSSTPLSEAKKPAALKPKVPKKEEPVKKDSV-AAGKPKEKGKIKVIKKEGKATEAVA
A-AV-GTGAATAAVVAAAGIAATGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVTKDI
KPQLELIEDEEKLKETEPVEAYVIQKETEVTKGPAESPDEGITTTEGEGECEQTPEELEP
VEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEEHICVSASKHSPT--
-------E-YEESAKAEADAYI----R-EKRESVASGDDRAEEDMDEAIEKGEAEQSEEE
A--D-EEDKAEDAREEEYEPEK-MEAEDYVMAVVDKAAE-AGGAEEQY-GFLTTPTKQPG
AQSPGREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPM
DEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYSQEYSKPAD---VTPLNGFSEGS
KTDATDGKDYNASASTISPPSSMEEDKFSRSALRDAYCSEVK---ASTTLDIKDTISA--
VSGEKLSPSKSPSLSPSPPSPLEKTPLGERSVNFSLTPNEIKVSAEAEVAS-VSPEVTQE
VVEEHCASPEDKTLEVVSPSQSVTGSAGHTPYYQSPTDEKSSHLPTEVIEKPPAVPVSFE
FSD-AKDDSERASVSPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYESFLSADDKASGR
GAESPFEEKSEKQSSPDQVSPVSEMTSTSLYQDKQEGK-STDFVPIKEDFGQEKKTDDVE
ATSSQPALALDERKLG-DVSPTQIDVSQFGSFKEDTKMSISEGTVSDKSATPVDEGVAED
TYSHMEGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTF
QETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQDHRS-EQSSMSIEFGQESPEHSLAM
DFSRQSPDHPTVGAGVLHITENGPTEVDYSPSDMQDSSLSHKIPPMEEP-SYTQDNDLSE
LISVSQVEASPSTSSAHTPSQIASPLQEDTLSDVAPPRDMSLYASLTSEKVQSLEGEKLS
PKSDISPLTPRESSPLYSPTFSDSTSAVKEKTAACHTSS-SPPIDAASAEPYGFRASVLF
DTMQHHLALNRDLATPGLEK---DSGGKTPGDFSYAYQKPEKTTRSPDE-EDYDYESYEK

PF00414 // ENSGT00550000074593_0_Domain_5 (2101, 2117)

TTRTSDVGGYYYEKIERTTKSPSDSGYSYETIGK

PF00414 // ENSGT00550000074593_0_Domain_7 (2135, 2151)

TTKTPEDGDYSYEIIEKTTRTPEEGG
YSYDISEKTASPPEVSGYSYEKTERS-RRLLDDISNGYDDSEDG

PF00414 // ENSGT00550000074593_0_Domain_12 (2205, 2220)

GHTLGDPSYSYETTEK
ITS-FPESESYSYETATKM

PF00414 // ENSGT00550000074593_0_Domain_14 (2240, 2256)

TRTPDTS-TYCYETTE

ENSGT00550000074593_0_Linker_14_15 (2256, 2257)

K

PF00414 // ENSGT00550000074593_0_Domain_15 (2257, 2289)

IARTPQASTYSYETS---------
--------DLC---YTAE--------------KKSPSEARQDVDLCLVSSCEYKHPKTEL
SPSFINPNPLEWFASEEPTEESEKPLTQSGGAPPPPGGKQQGRQCDETPPTSVSESAPSQ
TDSDVPPETEECPSITADANIDSEDESETIPTDKTVTYKHMDPPPAPVQDRSPSPRHPDV
SMVDPEALALEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKSDGKSKPLAASPKPAGL
KESSDKVSRVASPKKKESVEKAAKPT-TTPEVK--AARGEEKDKETKNAANASASKSAKT
ATAGRLRRPGIEYM------P--QPFYLIYN----------LYISLFGF-------VLGR
------------------------------------------------------------
------------------

------------------------------------------------------------
------------------------------------------------------------
-----MATVVVEAAEPEPSGSIANPAASTSPSLSHRFLDSKFYLLVVVGEIVTEEHLRRA
IGNIE-LGIRSWDTNLIECNLDQELKLFVSRHSARFSPEVP-----------GQKILHHR
SDVLETVVLINPSDEAVSTEVRLMITDAARHKLLVLTGQCFENTGELILQSGSFSFQNFI
EIFTDQEIGELLSTTHPANKASLTLFCPEEGDWKNSNLDRHNLQDFINIKLNSASILPEM
EGLSEFTEYLSESVEVPSPFDILEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFNML
INGGSERKSCFWKLIRHLDRVDSILLTHIGDDNLPGINSMLQRKIAELEEEQSQGSTTNS
DWMKNLISPDLGVVFLNVPENLKNPEPNIKMKRSIEEACFTLQYLNKLSMKPEPLFRSVG
NTIDPVILFQKMGVGKLEMYVLNPVKSSKEMQYFMQQW---T-GTN-KDKAE-LILPN-G
QEID-IPISYL-TSVSS-LIVWHPANPAEKIIRVLFPGNSTQYNILEGLEKLKHLDFLKQ
PLATQKDLTGQVVTPA-VKQVKLKQRADSRESLKPAAKPLAS-KSVRKESKEETPDVAKA
NH-VEKAPKVESKEKVTVKKDK------PIKTETKPPMTEKEVPSK--EELPPVKAEVAE
K---PTTDVKPKVAKEKTVKKETKAKSEEKKEE--KEKPKKEVAKKEDKTPIKKEEKPKK
EEVKKEVKKEIKKEEKKEPKKEVKKETPLKEAKKEVKKEEKKEIKKEEKEPKKEIKRLPK
DTKKSSTPLSEAKKPAALKPKVPKKEEAVKKDSV-AAGKPKEKGKIKVIKKEGKTSEAAA
A-AI-GSVAATAALAAAAGVAGAGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVAKDM
KPQLELIEDEEKLKETEPVECYVIQKETEVIKGPAESPDEGITTTEGEGECEQTPEELEP
VEKQGVDDIEKYEDEGAGFEESSETGDYEEKAETEEAEEPEEDVEENVCVSTSKHSLM--
-------EE-EESAKAEADVHI----K-EKRESLVSGDDRAEEDMNEVVEKGEAEQSEEE
G--D-EEDRAEDAREEEYEPEK-AEAEDYVMAVVDKAAE-AGGVEDQY-GFLTTAIKQPG
AQSPAREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPM
DEMSTPRDVMSDEINNEETESPSQEFVNITKYESALYAQEYSKP-A---VTTLNGLSEGS
KTDATDGKDYNASASTISPPSSMEEDKFSKSALRDAYCSEEKDLRASATLTIKESIPA--
VSDEKLSPPKSPSLSPSPPSPIEKTPLGERSVNFSLTPNEIQVSAEAEAAP-VSPEVTQE
VVEEHCASPEDKTLEVVSPSQSVTGSAGHTPYYQSPTEEKSSQLPTEVTEKPPAVPVSFE
FSD-AKDENERASISPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYEGFLSADDKVAGR
GAESPFEGKNGKQGFPDKLSPVSDITSTGLFQNKEEGK-STDFIPIKEDFGQEKKTDDVE
ALSSQSGLALDERKLGGDVSPTQIDVSQFGSFKEDTKMSISEGTVSDKSATPVDEGVAED
TYSHMEGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTF
QETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQDHRS-EQSSMSIEFGQESPEHSLAM
DFSRQSPDHPTVGASMLHITENGPTEVDYSPSDMQDSSLSHKIPPMEEP-SYTQDNDLSE
LISVSQVEASPSTSSAHTPSQIASPLQEDTLSDVAPPRDISLYASLTSEKVQSLEGEKLS
PKSDISPLTPRESSPLYSPSFSDSTSAVKESIAVCHTSS-PPAMDAASAEPYGFRASMLF
DTMQHQLALNRDLTSTGVEK---DSGGKTPGDFSYAYQKPEKTTRSPDG-EGYDYESYEK

PF00414 // ENSGT00550000074593_0_Domain_5 (2101, 2117)

TTRPPDVSGYYYEKTERTTKSPSDSSYSYDTIEKTTKTPEDGGYAYDIAEKTTRSPEEGE
YSYETSEK

PF00414 // ENSGT00550000074593_0_Domain_10 (2169, 2185)

TMRTPEVSGYSYEKTERS-RRLLDDISNGYDDPED

PF00414 // ENSGT00550000074593_0_Domain_12 (2204, 2220)

GGHTLGDSSYSYETTEK
IAS-FSESGSFSYETSTTATRTPEAS-KYCYETAEK

PF00414 // ENSGT00550000074593_0_Domain_15 (2257, 2289)

ITRTPQASTYSYETS---------
--------DQC---YTAE--------------KKSPSEARQDVDLCLVSSCEYKHPKTEL
SPSFINPNPLEWFASEEPTEESEKPLTQAGGAPPPPGGKPQGRQCDETPPTSVSESAPSQ
TDSDVPPETEECPSITADANIDSEDESETIPTDKTVTYRHMDPPPAPMQDRSPSPRHPDV
SMMDPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKGDGKSKPSAASPKPAGL
KESSDKVSRVASPKKKESVEKATKTT-TTPEVK--AARGEEKDKDTKNAANASTSKSVKT
AA---A-GPGTTKPSKPSAVPPGPPVYLDLCYIPNHSNSKNVDVEFFKRVRSSYYVVSGN
DPAAEEPSRAVLDALLEGKAQWGSNMQVTLIPTHDSEVMREWYQETHEKQQDLNIMVLAS
SSTVVMQDESFPACKIEL

------------------------------------------------------------
------------------------------------------------------------
-----MATVVVEATEPEPSGSIGNPAASTSPSLSHRFLDSKFYLLVVVGETVTEEHLRRA
IGNIE-LGIRSWDTNLIECNLDQELKLFVSRHSARFSPEVP-----------GQKILHHR
SDVLETVVLINPSDEAVSTEVRLMITDAARHKLLVLTGQCFENTGELILQSGSFSFQNFI
EIFTDQEIGELLSTTHPANKASLTLFCPEEGDWKNSNLDRHNLQDFINIKLNSASILPEM
EGLSEFTEYLSESVEVPSPFDILEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFNML
INGGSERKSCFWKLIRHLDRVDSILLTHIGDDNLPGINSMLQRKIAELEEERSQGSTSNS
DWMKNLISPDLGVVFLNVPENLKDPEPNIKMKRSIEEACFTLQYLNKLSMKPEPLFRSVG
NTIEPVILFQKMGVGKLEMYVLNPVKSSKEMQYFMQQW---T-GTN-KDKAE-LILPN-G
QEVD-IPISYL-TSVSS-LIVWHPANPAEKIIRVLFPGNSTQYNILEGLEKLKHLDFLKQ
PLATQKDLTGQVPTPP-VKQVKLKQRADSRESLKPATKPVAS-KSVRKESKEETPEVTKA
SQ-VEKTPKVESKEKVLVKKDK------PVKTESKPSVTEKEVSSK--EEQSPVKAEVAE
K---QATESKPKVTKDKVVKKEIKTKLEEKKE----EKPKKEVVKKEDKTPLKKDEKPRK
EEVKKEIKKEIKKEERKELKKEVKKETPLKDAKKEVKKEEKKEVKKEEKEPKKEIKKISK
DIKK-STPLSDTKKPSALKPKVAKKEESTKKEPL-AAGKLKDKGKVKVIKKEGKTTEAAA
TALG-TAATTAAAVAAAGIAA-SGPVKELEAERSLMSSPEDLTKDFEELKAEEIDVAKDI
KPQLELIEDEEKLKETQPGEAYVIQKETEVSKGSAESPDEGITTTEGEGECEQTPEELEP
VEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEDNASGSASKHSPT--
--------EDDESAKAEADVHL----K-EKRESVVSGDDRAEEDMDDVLEKGEAEQSEEE
G--EE-EDKAEDAREEGYEPDK-TEAEDYVMAVADKAAE-AGVTEEQY-GFLGMSAKQPG
IQSPSREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPM
DEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYSQEYSKPA----VASFNGLSEGS
KTDATDGKDYNASASTISPPSSMEEDKFSKSALRDAYCSEEKELKASAELDI----KD--
VSDERLSPAKSPSLSPSPPSPIEKTPLGERSVNFSLTPNEIKVSAEGEARS-VSPGVTQA
VVEEHCASPEEKTLEVVSPSQSVTGSAGHTPYYQSPTDEKSSHLPTEVTEKPQAVPVSFE
FSE-AKDENERASLSPMDEPVPDSESPVEKVLSPLRSPPLLGSESPYEDFLSADSKVLGR
RSESPFERKNGKQGFPDRESPVSDLTSTGLYQDKREEK-STGFIPIKEDFGPEKKTSDVE
TMSSQSALALDERKLGGDVSPTQIDVSQFGSFKEDTKMSISEGTVSDKSATPVDEGVAED
TYSHMEGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTF
QETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQDHRS-EQSSMSIEFGQESPEHSLAM
DFSRQSPDHPTLGASVLHITENGPTEVDYSPSDIQDSSLSHKIPPTEEP-SYTQDNDLSE
LISVSQVEASPSTSSAHTPSQIASPLQEDTLSDVVPPREMSLYASLASEKVQSLEGEKLS
PKSDISPLTPRESSPLYSPGFSDSTSAAKETAAAHQASS-SPPIDAAAAEPYGFRSSMLF
DTMQHHLALNRDLTTSSVEK---DSGGKTPGDFNYAYQKPENATGSPDE-EDYDYESQEK

PF00414 // ENSGT00550000074593_0_Domain_5 (2101, 2117)

TIRTHDVGGYYYEKTE

ENSGT00550000074593_0_Linker_5_6 (2117, 2118)

R

PF00414 // ENSGT00550000074593_0_Domain_6 (2118, 2134)

TIKSPCDSGYSYETIEKTTKTPEDGGYTCEITEK

PF00414 // ENSGT00550000074593_0_Domain_9 (2152, 2168)

TTRTPEEGG
YSYEISE

ENSGT00550000074593_0_Linker_9_10 (2168, 2169)

K

PF00414 // ENSGT00550000074593_0_Domain_10 (2169, 2185)

TTRTPEVSGYTYEKTERS-RRLLDDISNGYDDTEDGGHTLGDCSYSYETTEK
ITS-FPESESYSYETSTK

PF00414 // ENSGT00550000074593_0_Domain_14 (2239, 2256)

TTRSPDTS-AYCYETME

ENSGT00550000074593_0_Linker_14_15 (2256, 2257)

K

PF00414 // ENSGT00550000074593_0_Domain_15 (2257, 2290)

ITKTPQASTYSYETS---------
--------DRC---YTTE--------------KKSPSEARQDVDLCLVSSCEFKHPKTEL
SPSFINPNPLEWFAGEEPTEESEKPLTQSGGAPPPSGGKQQGRQCDETPPTSVSESAPSQ
TDSDVPPETEECPSITADANIDSEDESETIPTDKTVTYKHMDPPPAPMQDRSPSPRHPDV
SMVDPDALAIDQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKGDGKSKPLAASPKPGAL
KESSDKVSRVASPKKKESVEKATKTT-TTPEVK--ATCGEEKDKETKNAANASASKSVKT
VTA----GPGTAKTAKSSSVPPGLPVYLDLCYIPNHSNSKNVDVEFFKRVRSSYYVVSGN
DPAAEEPSRAVLDALLEGKAQWGSNMQVTLIPTHDSEVMREWYQETHEKQQDLNIMVLAS
SSTVVMQDESFPACKIEL

------------------------------------------------------------
------------------------------------------------------------
-----MATVVVEATEPEPSGSIANPAASTSPSLSHRFLDSKFYLLVVVGEIVTEEHLRRA
IGNIE-LGIRSWDTNLIECNLDQELKLFVSRHSARFSPEVP-----------GQKILHHR
SDILETVVLINPSDEAVSTEVRLMITDAARHKLLVLTGQCFENTGELILQSGSFSFQNFI
EIFTDQEIGELLSTTHPANKASLTLFCPEEGDWKNSNLDRHNLQDFINIKLNSASILPEM
EGLSEFTEYLSESVEVPSPFDILEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFNML
INGGSERKSCFWKLIRHLDRVDSILLTHIGDDNLPGINSMLQRKIAELEEEQSQGSTTNS
DWMKNLISPDLGVVFLNVPENLKNPEPNIKMKRSIEEACFTLQYLNKLSMKPEPLFRSVG
NTIDPVILFQKMGVGKLEMYVLNPVKSSKEMQYFMQQW---T-GTN-KDKAE-FILPN-G
QEVD-LPISYL-TSVSS-LIVWHPANPAEKIIRVLFPGNSTQYNILEGLEKLKHLDFLKQ
PLATQKDLTGQVPTPV-VKQTKLKQRADSRESLKPATKPLPS-KTVRKESKEETPEVTKV
NH-VEKPPKVESKEKVTVKKDK------PVKTETKPSVTEKEVPSK--EEPSPVKAEVAE
K---QATDVKPKAAKEKTVKKEAKVKPEDKKEE--KEKPKKEVAKKEDKTPLKKEEKPKK
EEVKKEVKKEIKKEEKKEPKKEVKKETPPKEAKKEVKKEEKKDMKKEEKEPKKEIKKLPK
DSKKSSTPLSEAKKPAALKPKVPKKEESVKKDSL-ATGKPKEKGKIKVIKKEGKAAEAVA
AA-V-ATGAT--TAAVAAGIVATGPTKELEAERSLMSSPEDLTKDFEELKAEEVDITKDI
KPQLELIEDEGKLKETEPVEAYVIQKETEVTKGSAESPDEGITTTEGEGECEQTPEELEP
VEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEEHVCVSTSKHSPT--
-------ED-EESAKAEADAYI----R-EKRESVASGDDRAEEDMDEAIEKGEAEQSEEE
A--D-EEDKAEDAREEEYEPEK-IEAEDYVMAVVDKAAE-AGGAEEQY-GFLTTPTKQPG
AQSPGREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPM
DEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYSQEYSKPAA---VTPLNGFSEGS
KTDATDGKDYNASASTISPPSSMEEDKFSRSALRDAYCSEVK---ASTTLDIKDAISA--
VSGDKLSPSKSPSLSPSPPSPIEKTPLGERSVNFSLTPNEIKVSAEAEVAP-VSPEVTQE
VVEEHCASPEDKTLEVVSPSQSVTGSAGHTPYYQSPTEEKSSHLPTEVIEKPPAVPVSFE
FSD-AKDENERASISPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYERFLSADGKASGR
GAESPFEEKSGKQGSPDQISPVSETTATSLYQDKQEGK-STDFVPIKEDFGQEKKIDDGE
AMSAQPALALDERKLG-DVSPTQIDVSQFGSLKEDTKMSISEGTVSDKSATPVDEGVAED
TYSHMEGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTF
QETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQDHRS-EQSSMSIEFGQESPEHSLAM
DFSRQSPDHPTVGAGVLHITENGPTEVDYSPSDMQDSSLSHKIPPMEEP-SYTQDNDLSE
LISVSQVEASPSTSSAHTPSQIASPLQEDTLSDVAPPRDMSLYASLTSEKVQSLEGEKLS
PKSDISPLTPRESSPLYSPTFSDSTSAVKEKTAACHTSS-SPPIDAASAEPYGFRASVLF
DTMQHHLALNRDLATPGME----DSGGKTPGDFSYAYQKPEKTTRSPDE-EDYNYESYEK
TTRTSDVGSYYYEKTER

PF00414 // ENSGT00550000074593_0_Domain_6 (2118, 2134)

TTKSPSDSGYSYETIE

ENSGT00550000074593_0_Linker_6_7 (2134, 2135)

K

PF00414 // ENSGT00550000074593_0_Domain_7 (2135, 2151)

TTKTPEDGDYSYEIIE

ENSGT00550000074593_0_Linker_7_9 (2151, 2152)

K

PF00414 // ENSGT00550000074593_0_Domain_9 (2152, 2168)

TTRTPEEGG
YSYEISEKTTSPPEMSGYSYEKTERS-RRLLDDISNGYDDSEDG

PF00414 // ENSGT00550000074593_0_Domain_12 (2205, 2220)

GHTLGDPSYSYETTEK
ITS-YPESESYSYETSAKM

PF00414 // ENSGT00550000074593_0_Domain_14 (2240, 2256)

TRTPDTS-TYCYETTEKISRTPQASTYSYETS---------
--------DLC---YTAE--------------KKSPSEARQDVDLCLVSSCEYKHPKTEL
SPSFINPNPLEWFASEEPTEESEKPLTQSGGAPPPPGGKQQGRQCDETPPTSVSESAPSQ
TDSDVPPETEECPSITADANIDSEDESETIPTDKTVTYKHMDPPPAPVQDRSPSPRHPDV
SMVDPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKSDGKSKPLAASPKPGGL
KESSDKVSRVASPKKKESVEKAAKPT-TTPEVK--AARGEEKDKETKNAANASASKSAKT
ATA----GPGTTKTTKSSAVPPGLPVYLDLCYIPNHSNSKNVDVEFFKRVRSSYYVVSGN
DPAAEEPSRAVLDALLEGKAQWGSNMQVTLIPTHDSEVMREWYQETHEKQQDLNIMVLAS
SSTVVMQDESFPACKIEL

------------------------------------------------------------
------------------------------------------------------------
-----MATVVVEATEPEPSGSIANPAASTSPSLSHRFLDSKFYLLVVVGEIVTEEHLRRA
IGNIE-LGIRSWDTNLIECNLDQELKLFVSRHSARFSPEVP-----------GQKILHHR
SDILETVVLINPSDEAVSTEVRLMITDAARHKLLVLTGQCFENTGELILQSGSFSFQNFI
EIFTDQEIGELLSTTHPANKASLTLFCPEEGDWKNSNLDRHNLQDFINIKLNSASILPEM
EGLSEFTEYLSESVEVPSPFDILEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFNML
INGGSERKSCFWKLIRHLDRVDSILLTHIGDDNLPGINSMLQRKIAELEEEQSQGSTTNS
DWMKNLISPDLGVVFLNVPENLKNPEPNIKMKRSIEEACFTLQYLNKLSMKPEPLFRSIG
NTIDPVILFQKMGVGKLEMYVLNPVKSSKEMQYFMQQW---T-GTN-KDKAE-LVLPN-G
QEVD-LPISYL-TSVSS-LIVWHPANPAEKIIRVLFPGNSTQYNILEGLEKLKHLDFLKQ
PLATQKDLTGQVPTPV-VKQTKLKQRADSRESLKPATKPLPS-KTVRKESKEETPEVTKV
NH-VEKPPKVESKEKVTVKKDK------PAKTETKPSVTEKEVPSK--EEPSPVKAEVAE
K---QAADVKPKAAKEKTVKKEAKVKPEDKKEE--KEKPKKEVAKKEEKTPIKKEEKPKK
EELKKEVKKETKKEEKKEPKKEVKKETPPKEAKKEVKKEEKKDVKKEEKEPKKEIKKLPK
DTKKSSTPLSEAKKPAALKPKVPKKEESVKKDSV-AAGKPKEKGKIKVVKKEGKPAEAVA
AAVA-AGATAA---AAAAGIAATGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVTKDI
KPQLELIEDEEKLKETKPVEAYVIQKETEVTKGSAESPDEGITTTEGEGECEQTPEELEP
VEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEEHVCVSTSKHSPT--
--------EDEESAKAEADAYI----R-EKRESVASGDDRAEEDMDEAIEKGEAEQSEEE
A--DE-EDKAEDAREEEYEPEK-IEAEDYVMAVVDKAAE-AGGAEEQY-GFLTTPAKQPG
AQSPGREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPM
DEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYSQEYSKPAA---VTPLNGFSEGS
KTDATDGKDYNASASTISPPSSMEEDKFSRSALRDAYCSEVKA---SPTLDIKDAISA--
VSGEKLSPSKSPSLSPSPPSPIEKTPLGERSVNFSLTPNEIKVSAEAEVVP-VSPEVTQE
VVEEHCASPEDKTLEVVSPSQSVTGSAGHTPYYQSPTEEKSSHLPTEVIEKPPAVPVSFE
FSD-AKDENERASVSPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYESFLSADGKASGR
GAESPFEEKSGKPGSPDQVSPVSETTSTSLYQDKQEGK-GTDFVPIKEDFGQEKKIDDGE
AMSAQPALALDERKLG-DVSPTQIDVSQFGSLKEDTKMSISEGTVSDKSATPVDEGVAED
TYSHMEGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTF
QETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQEHRS-EQSSMSIEFGQESPEHSLAM
DFSRQSPDHPTVGAGVLHITENGPTEVDYSPSDMQDSSLSHKIPPMEEP-SYTQDNDLSE
LISVSQVEASPSTSSAHTPSQIASPLQEDTLSDVAPPRDMSLYASLTSEKVQSLEGEKLS
PKSDISPLTPRESSPLYSPTFSDSTSAVKEKTAVCHTSS-SPPIDAASAEPYGFRASVLF
DTMQHHLALNRDLATPGME----DSGGKTPGDFSYAYQKPEKTTRSPDE-EDYDYESYEK
TTRTSDVGGYYYEKTKRTTKSPSDSGYSYETIGK

PF00414 // ENSGT00550000074593_0_Domain_7 (2135, 2151)

TTKTPEDGDYSYEIIE

ENSGT00550000074593_0_Linker_7_9 (2151, 2152)

K

PF00414 // ENSGT00550000074593_0_Domain_9 (2152, 2168)

TTRTPEEGG
YSYEISEKTTSPPEMSGYSYEKTERS-RRLLDDISNGYDDSEDG

PF00414 // ENSGT00550000074593_0_Domain_12 (2205, 2220)

GHTLGDPSYSYETTEK
ITS-YPESESYSYETSTK

PF00414 // ENSGT00550000074593_0_Domain_14 (2239, 2256)

TTRTPDTS-TYCYETTE

ENSGT00550000074593_0_Linker_14_15 (2256, 2257)

K

PF00414 // ENSGT00550000074593_0_Domain_15 (2257, 2289)

ITRTPQASTYSYETS---------
--------DLC---YSAE--------------KKSPSEARQDVDLCLVSSCEYKHPKTEL
SPSFINPNPLEWFASEEPTEESEKPLTQSGGAPPPPGGKQQGRQCDETPPTSVSESAPSQ
TDSDVPPETEECPSITADANIDSEDESETIPTDKTVTYKHMDPPPAPVQDRSPSPRHPDV
SMVDPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKSDGKSKPLAASPKPGGL
KESSDKVSRVASPKKKESVEKAAKPT-STPEVK--AARGEEKDKETKNAANASASKSAKT
ATA----GPGTTKTTKSSAVPPGLPVYLDLCYIPNHSNSKNVDVEFFKRVRSSYYVVSGN
DPAAEEPSRAVLDALLEGKAQWGSNMQVTLIPTHDSEVMREWYQETHEKQQDLNIMVLAS
SSTVVMQDESFPACKIEL

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------MITDAARHKLLVLTGQCFENTGELILQSGSFSFQNFI
EIFTDQEIGELLSTTHPANKASLTLFCPEEGDWKNSNLDRHNLQDFINIKLNSASILPEM
EGLSEFTEYLSESVEVPSPFDILEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFNML
INGGSERKSCFWKLIRHLDRVDSILLTHIGDDNLPGINSMLQRKIAELEEEQSQGSTTNS
DWMKNLISPDLGVVFLNVPENLKNPEPNIKMKRSLEEACFTLQYLNKLSMKPEPLFRSVS
NTIEPVILFQKMGVGKLEMYVLNPVKTSKEMQYFMQQW---T-GTS-KDKAE-LLLPN-G
QEVD-IPISYL-TSVSS-LIVWHPANPAEKIIRVLFPGNSTQYNILEGLEKLKHLDFLKQ
PLATQKDLTGQVPTSA-TKQVKLKQRADSRESLKPATKPLPS-KSVRKESKEESPDVTKA
NH-VEKPPKVESKEKVTVKKDK------PVKTETKPPVTEKEAPSK--DEPSPVKAEVAD
K---QATDVKPKVTKEKTVKKETKVKSEEKKEE--KEKPKKEVAKKEDKTPVKKEEKPKK
EEVKKEVKKEIKKEEKKELKKEVKKETPLKEVKKDVKKEEKKEIKKEEKEPKKEIKKVTK
DTKK-STPLPEAKKPAAIKPKVPKKEESVRKDSV-AAGKPKEKGKIKVIKKEGKTTEAAA
A-AV-GTAAATAATVAAAAVAATGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVTKDI
KPQLELIEDEEKLKETEPVEAYVIQKETEVIKGSAESPDEGITTTEGEGECEQTPEELEP
VEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEENVCVSTSKHSLT--
-------ED-EESAKAEADVHI----R-EKRESVASGDDRAEEDMDEAVEKGEAEQSEEE
G--E-EEDKAEDAREEEYEPEK-AEAEDYVMAVVDKAAE-ASGADGQY-GFLSTPAKQVG
AQALGREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPM
DEMSTPRDVMSDETNNDETESPSQEFVNITKYESSLYSQEYSKPA----VTSLNGLSEGS
KTDATDGKDYNASASTISPPSSMEEDKFSRSALRDAYYSEVKEVKASAMLEIKDTTSV--
VSDEKLSPPKSPSLSPSPPSPVEKTPLGERSVNFSLMPNEIKVSTEAEAVS-VSPEVTQE
VVEEHCASPEDKTLEVVSPSQSVTGSAGHTPYYQSPTDEKSSHLPTEVIEKPPALPVSFE
FSD-AKDENERASISPMDEPVPDSESPIEKVLSPLRSPPLIGSEPAYESFLSADGKTSGR
FTE-------EKKGFPDQMRPVPEMTSAGLYQDKQEGK-STDFIPIKEDFGQEKKTDDAE
ALSSQPALALDERKLG-DVSPTQIDVSQFGSFKEDTKMSISEGTVSDKSATPVDEGVAED
TYSHMEGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTF
QETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQEHRS-EQSSMSIEFGQESPEHSLAM
DFSRQSPDHPTVGAGMLHITENGPTEVDYSPSDMQDSSLSHKIPPMEEP-SYTQDNDLSE
LISVSQVEASPSTSSAHTPSQIASPLQEDTLSDVAPPRDISLYASLTSEKVQSLEGEKLS
PKSDISPLTPRESSPLYSPSFSDSTSAVKENIAASHTSS-SPPIDAASAEPYGFRASMLF
DTMQHHLALNRDLTTSGLEK---DSGGKTPGDFSYAYQKAEKTTRSPDE-EDYNYESYEK

PF00414 // ENSGT00550000074593_0_Domain_5 (2101, 2117)

TTRPPDVGGYYYEKTE

ENSGT00550000074593_0_Linker_5_6 (2117, 2118)

R

PF00414 // ENSGT00550000074593_0_Domain_6 (2118, 2134)

TTKSPGDSDYSYETIE

ENSGT00550000074593_0_Linker_6_7 (2134, 2135)

K

PF00414 // ENSGT00550000074593_0_Domain_7 (2135, 2151)

TTKTPEDGGYAYEIIEKTTRPFEEGG
YSYEISEK

PF00414 // ENSGT00550000074593_0_Domain_10 (2169, 2185)

TTRTPTVSGYSYEKTERS-RRLLDDISNGYDDSEDGGHTLGDSSYSYEATEK
IAS-YPESESYSYETCTK

PF00414 // ENSGT00550000074593_0_Domain_14 (2239, 2256)

TTRSPDTS-TYCYETTE

ENSGT00550000074593_0_Linker_14_15 (2256, 2257)

K

PF00414 // ENSGT00550000074593_0_Domain_15 (2257, 2290)

ITKTPQASTYSYETS---------
--------DRS---YSVE--------------KKSPSEARQDVDLCLVSSCEYKHPKTEL
SPSFINPNPLEWFASEEPTEESEKPLTQAGGAPPPPGGKQQGRQCDETPPTSVSESAPSQ
TDSDVPPETEECPSITADANIDSEDESETIPTDKTVTYKHMDPPPAPMQDRSPSPRHPDV
SMVDPEALALEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKSDGKSKPLAASPKPAGL
KESSDKVSRVASPKKKESVEKATKTT-TTPEVK--AARGEEKDKETKNAANASTSKSVKT
AAA----GSGTTKTVKPSAVPPGLPVYLDLCYIPNHSNSKNVDVEFFKRVRSSYYVVSGN
DPAAEEPSRAVLDALLEGKAQWGSNMQVTLIPTHDSEVMREWYQETHEKQQDLNIMVLAS
SSTVVMQDESFPACKIEL

------------------------------------------------------------
------------------------------------------------------------
-----MATVVVEAAEPEPSGSLANPAASTSPSLSHRFLDSKFYLLVVVGEIVTEEHLRRA
IGNIEPPGIRSWDTNLIECNLDQELKLFVSRHSARFSPEVPXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXX-----------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXIGELLSTTHPANKASLTLFCPEEGDWKNSNLDRHNLQDFINIKLNSASILPEM
EGLSEFTEYLSESVEVPSPFDILEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFNML
INGGSERKSCFWKLIRHLDRVDSILLTHIGDDNLPGINSMLQRKIAELEEEQSQGSTTNS
DWMKNLISPDLGVVFLNVPENLKNPEPNIKMKRSIEEACFTLQYLNKXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXX--XX-XXXXXXXXXXXXXXXXXXX--XXXXXXXXXXXX
X---XXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXX------
XXXXXXXXXXXXXXXX-X-------XXXXXXXXXXXXX---XXXX---XXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXAESDEGITTTEGEGVCEQTPEELEP
VEKQRVDDIEKYEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEENGYVSTSKHSVL--
--------EEEDSTKAEADVHLK-----KKRESVASGDDRAEEDMDEAVEKGEAEPSEEE
G---DEEDKAEDIREEDYEAEK-VEAEDYVMAVVDKAAE-AGGAEDQY-GFLSTSTKQVG
AQSPGQAPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPM
DEMSTPRDVMSDETNNEETESPSQEFANITKYESSLYPQEYSKHA----VTSLNGLSEGS
KTDATDGKDYNASASTISPPSSMEEDKFSRSVLKDAYCSEEKEVKASTMLNIKDAVST--
VSPDTRSPSKSPSLSPSPPSPIEKTPLGERSVNFSLTPNEIKVSAEAQAVP-ASPEVTQE
VVEEHCASPEEKTLEVVSPSQSVTGSAGHTPYYQSPTEEKASQLPTEVNTKTTAASESFE
FND-AKDEHERASISPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYESFLSADDKAPGG
CVESPFEGKNEKPGFSDQISPVSDVNSTGLFQGQQKGK-STDFIPIKEDFGQEKKADDVD
AASSQSGLALDERKLGGEVSPTQIDVSQFGSFKEDTKMSISEGTVSDKSATPVDEGVAED
TYSHMEGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTF
QETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQDHRS-EQSSMSVEFGQESPEHSLAI
DFSRQSPDHPAVGASVLHITENGPTEVDYSPSDMQDSSLAHKMPPLEEPSSYTQDNDLSE
LISVSQVEASPSTSSAHTPSQIASPLQEEALSDV-PPRDISLYASLTSEKGQNLEGEKLS
PKSDISPLTPRESSPLYSPGFSDSTSAVKENVSACHTSS-LPPMDAASSEPYGFRASMLF
DTMQHHLALNRDFNTSGTEK---DNGGKTPGDFNYAYQKPEASRSPGEEGYDYDYETVRA
----PDXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXDISNGYYDTDDSGHTLGDCSYSYETEK-
IS-SFPESESYSYEKSTK

PF00414 // ENSGT00550000074593_0_Domain_14 (2239, 2256)

TTRTPEMS-TYCYETSE

ENSGT00550000074593_0_Linker_14_15 (2256, 2257)

K

PF00414 // ENSGT00550000074593_0_Domain_15 (2257, 2290)

ITRTPQSSTYSYETS---------
--------DQC---YPAD--------------KKSPSEARQEVDLCLVSSCEYKHPKTEL
SPSFINPNPLEWFASEEQPEEGEKPLTQSGGAPPPPGGKSQGRQCDETPPTSVSESAPSQ
TDSDVPPETEECPSITADANIDSEDESETIPTDKTVTYKHMDPPPAPMPDRSPSPRHPDV
SMMDPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKGDGKSKPSAASPKPAGL
KESLDKVSRVASPKKKESVEKATKAT-TTPEVK--AARGEEKDKETKNAANASTSKSVKT
ATA----GPGTTKTAKPSAVPPGPPVYLDLCYIPNHSNSKNVDAEFFKRVRSSYYVVSGN
DPAAEEPSRAVLDALLEGRAQWGSNMQVTLIPTHDSEVMREWYQETHEKQQDLNIMVLAS
SSTVVMQDESFPACKIEL

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------MITDAARHKLLVLTGQCFENTGELILQSGSFSFQNFI
EIFTDQEIGELLSTTHPANKASLTLFCPEEGDWKNSNLDRHNLQDFINIKLNSASILPEM
EGLSEFTEYLSESVEVLSPFDILEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFNML
INGGSERKSCFWKLIRHLDRVDSILLTHIGDDNLPGINSMLQRKIAELEEEQSQGSTTNS
DWMKNLISPDLGVVFLNVPENLKTPEPNMKMKRSLEEACFTLQYLNKLSMKPEPLFRSVG
NTIDPVILFQKMGVGKLEMYVLNPVKSSKEMQYFMQQW---T-GTN-RDKAE-LILPN-G
QEVD-IPIPYL-TSVSS-LIVWHPANPAEKIIRVLFPGNSTQYNILEGLEKLKHLDFLKQ
PLATQKDLTGQVPAPA-VKQVKLKQRADSRENLKPAAKPAPS-KTVRKESKEEAPEVPKA
NQ-VEKPPKVESKEKVTVKKDKPVKKDKPVKTEPKPAAVDKEAPSK--EEQPPVKAEVAD
K---QAADVKPKVSKEKTVKKEVKAKPDEKKDE--KEKPKKEVAKKEDKTPVKKEEKPKK
EEVKKEVKKEIKKEEKKEPKKEVKKETPLKEAKKEVKKEEKKEVKKEDKEPKKEIKKLPK
DTKKPATPLSEAKKPAALKPKVPKKEEPVKKDAA-AAGKPKEKAKVKVIKKEGKTAEAAV
AVGA------AAVGAAVAAVAAAGPLRELEAERSLMSSPEDLTKDFEELKAEEVDVAKAL
KPQLELIDEDAKRKESEAGEAYALQKHTEVIQGPAESPDEGITTTEGEGECEQTPEELEP
AEKPGVEDTERFEDEGAGFEESSEAGDYEEKAETEEAEEPEEDAEESAAVSAPKPGLA--
--------EDEEVAKAEADVHI----R-EKRESVASGDDRAEEDMDEAIEKGEAEQSEEE
EGEEEEEDKAEDAREEEYEPEK-AEAEDYVMAVVDKAAE-AGGAEDQY-GFLTASLKPPG
AQSPSREPASSIHDETLPGGSESEATASDEDNREDQPEEFTATSGYTQSTIEISSEPTPM
DEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYSQEYVKPA----VTSLNGLSDGS
KTDATEGKDYNASASTISPPSSMEEDKFSRSALRDAYYSEEKEGQARAALDIKDTFSA--
VSDEKLSPPKSPARSPSPPSPIEKTPLGERSVNFSLTPNEIKASAEAEAAP-VSPEVTKE
VVEERCASPEEKTLEVVSPSQSVTGSAGHTPYYQSPTEEKSSHLPTEVVEKPPAVPVRFE
FSD-AKDERERASVSPMDEPVPDSESPLEKVLSPLRSPPLLGSESPYDSFLSVDDQAPGR
GTESPFEGKDGKPELLDQVSPVSDVTSAGLYQDKEEGK-GTDFVPIKEDVGPEK-TDDVE
SASSQPALALDDRKPG-DVSPTQIDVSQLGSFKEDTKMSISEGTVSDKSATPVDEGVAED
TYSHMEGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTF
QETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQEHRS-EQSSMSIEFGQESPEHSLAM
DFSRQSPDQPTMGAGALHITENGPTEVDYSPSDMQDSSLSHKIPPTEEP-SYTQDNDLSE
LISVSQVEASPSTSSAHTPSQIASPLQEDTLSDVAPPRDISLYASLTSEKVQSLGGEKLS
PKSDISPLTPRESSPLYSPSFSDSTSAVKESTEARHTSS-SPPIDAAVAEPYGFRASMLF
DTMQHHLALNRDLTTSSLEK---DSGGKTPGDFSYAYQTPEKLTRSPDE-EDYDSESYEK
STRSPDLGSCYYEQTER

PF00414 // ENSGT00550000074593_0_Domain_6 (2118, 2134)

TVKSPCDSGYSYETIEKTTKTPEDDGYACEITEK

PF00414 // ENSGT00550000074593_0_Domain_9 (2152, 2168)

TTRTPEEGS
YSYEISE

ENSGT00550000074593_0_Linker_9_10 (2168, 2169)

K

PF00414 // ENSGT00550000074593_0_Domain_10 (2169, 2185)

TTRTPDVSGYSYEKTERA-RRLLDDISNGYDDSED

PF00414 // ENSGT00550000074593_0_Domain_12 (2204, 2220)

GGHTLGDSSYSYETTEK
ISS-FPESESYSYETSMK

PF00414 // ENSGT00550000074593_0_Domain_14 (2239, 2255)

TTHTPDAS-TYCYESS

ENSGT00550000074593_0_Linker_14_15 (2255, 2257)

EN

PF00414 // ENSGT00550000074593_0_Domain_15 (2257, 2290)

ITKTPQASTYSYETS---------
--------DRC---YAAE---------------KSPSEARQEVDLCLVSSCEYKHPKTEL
SPSFINPNPLEWFASEEPTDDSEKPLTQSGGAPPPPGGKPQGRQCDETPPTSVSESAPSQ
TDSDVPPETEECPSITADANIDSEDESETIPTDKTVTYKHMDPPPAPVQDRSPSPRHPDV
SMVDPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKSDGKPKPLAASPKPASL
KESSDKVSRVASPKKKESVEKATKTS-ATPEVK--AARGDEKDKETKNAANASASKSAKT
ATA----GPGTTKTAKPSAVPPGLPVYLDLCYIPNHSNSKNVDVEFFKRVRSSYYVVSGN
DPAAEEPSRAVLDALLEGKAQWGSNMQVTLIPTHDSEVMREWYQETHEKQQDLNIMVLAS
SSTVVMQDESFPACKIEL

------------------------------------------------------------
------------------------------------------------------------
-----MATVVVEAAEPEPSGSIANPAATTSPSLSHRFLDSKFYLLVVVGEIVTEEHLRRA
IGNIE-LGIRSWDTNLIECNLDQELKLFVSRHSARFSPEVP-----------GQKILHHR
SDVLETVVLINPSDEAVSTEVRLMITDAARHKLLVLTGQCFENTGELILQSGSFSFQNFI
EIFTDQEIGELLSTTHPANKASLTLFCPEEGDWKNSNLDRHNLQDFINIKLNSASILPEM
EGLSEFTEYLSESVEVPSPFDILEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFNML
INGGSERKSCFWKLIRHLDRVDSILLTHIGDDNLPGINSMLQRKIAELEEEQSQGSTTNS
DWMKNLISPDLGVVFLNVPENLKNPEPNIKMKRSIEEACFTLQYLNKLSMKPEPLFRSVG
NTIDPVILFQKMGVGKLEMYVLNPVKSSKEMQYFMQQW---T-GTN-KDKAE-LILPN-G
QEID-IPISYL-TSVSS-LIVWHPANPAEKIIRVLFPGNSTQYNILEGLEKLKHLDFLKQ
PLATQKDLTGQVATPA-VKQVKLKQRADSRESLKPAAKPLPS-KAVRKESKEETPEVTKA
AQ-VEKPPKVESKEKVTVKKDK------PVKTETKPPVTEKEVPSK--EELPLAKAEGAE
K---QGADVKPKVAKEKTVKKETKAKPEEKKEEKEKEKPKKEVAKKEDKTPIKKEEKPKK
EEVKKEVKKDIKKEEKKEVKKEVKKETPLKEAKKEVKKEEKKEIKKEEKEPKKEIKKLPK
DTKKSTTPVSEAKKPAALKPKVPKKEEPVKKESVAAAGKPKEKGKIKVVKKEGRTAEAAA
AVAL-GTVATAAA--VAAGMAPAGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVAKDV
KPQLELIEDEEKLKETEPGEAYVIQKETEVIKGPAESPDEGITTTEGEGECEQTPEELEA
VEKQGVEDTEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEESVCTRTSKHSPV--
-------EEEEESAKAEADVHI----K-EKRESIASGDDRAEEDMDEALEKGDAEQSEEE
G--EEEEDKAEDAREEDYEPEK-AEAEDYVMAVVDKAAG-AGGAEDQY-GFLTTAAKQVG
AQSPVREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPM
DEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYSQEYAKP-A---VTSLNGLSEGS
KTDATDGKDYNASASTISPPSSMEEDKFSRSALRDAYCSEDKEVRASATLEVKDTVSA--
VSDEKLSPPKSPSLSPSPPSPIEKTPLGERSVNFSLTPNEIKVSAEAEVAP-VSPEVTQE
VVEEHCASPEDKTLEVVSPSQSVTGSAGHTPYYQSPTEEKSGHLPTEAIEKPAAVPVSFE
FSD-AKDESDRASISPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYESFLSADDKAPGR
YTESPFEGKNGKQGSPDQISPVSDTTSTGLFQDKEEGK-STDFIPIKEDFDQEKKTDDVE
ELSSQSGLALDERKLG-DVSPTQIDVSQFGSFKEDTKMSISEGTVSDKSATPVDEGVAED
TYSHMEGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTF
QETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQDHRS-EQSSMSIEFGQESPEHSLAM
DFSRQSPDHPTVGAGMLHITENGPTEVDYSPSDMQDSSLSHKIPPTEEP-SYTQDNDLSE
LISVSQVEASPSTSSAHTPSQIASPLQEDTLSDVVPPRDISLYASLTSEKVQSLEGEKLS
PKSDISPLTPRESSPLYSPSFSDSTSAVKESIAACHAAS-PPPTDAASAEPYGFRASMLF
DTMPHHLALSRDLATSVMEK---DSGGKTPGDFSYAYQKPEMTTRSPDE-ESYDYESYEK
TTRGADVSGYYYEKTDSP

PF00414 // ENSGT00550000074593_0_Domain_6 (2119, 2134)

AKSPCDSGYSYEAIE

ENSGT00550000074593_0_Linker_6_7 (2134, 2135)

K

PF00414 // ENSGT00550000074593_0_Domain_7 (2135, 2151)

TTKTPEEGGYAYEITE

ENSGT00550000074593_0_Linker_7_9 (2151, 2152)

K

PF00414 // ENSGT00550000074593_0_Domain_9 (2152, 2168)

ATRSPEEPG
YSYEISE

ENSGT00550000074593_0_Linker_9_10 (2168, 2169)

K

PF00414 // ENSGT00550000074593_0_Domain_10 (2169, 2185)

TARTPELSGYSYEKTERS-RRLLDDISNGYDDSEEG

PF00414 // ENSGT00550000074593_0_Domain_12 (2205, 2220)

GQTLGDSSYSYETTEK
AAS-FPESESYSYETSTA

PF00414 // ENSGT00550000074593_0_Domain_14 (2239, 2256)

TTRTPDTS-AYCYETAEKMARTPQASTYSYETS---------
--------DPC---YTAE--------------KRSPSEARQDVDLCLVSSCEYKHPKTEL
SPSFINPNPLEWFASEEPAEDSEKPLTQTGGAPPPPGGKPQGRQCDETPPTSVSESAPSQ
TDSDVPPETEECPSITADANIDSEDESETIPTDKTVTYKHMDPPPAPMQDRSPSPRHPDV
SMMDPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKADGKSKPSAASPKPGAL
KESSDKVSRVASPKKKESVEKATKTT-TTPEVK--ATRGEEKDKETKNAANASTSKSVKT
AT---A-GPGTTKTSKPSAVPPGPPVYLDLCYIPNHSNSKNVDVEFFKRVRSSYYVVSGN
DPAAEEPSRAVLDALLEGKAQWGSNMQVTLIPTHDSEVMREWYQETHEKQQDLNIMVLAS
SSTVVMQDESFPACKIEL

------------------------------------------------------------
------------------------------------------------------------
-----MATVVVEATEPEPSGSIANPAASTSPSLSHRFLDSKFYLLVVVGEIVTEEHLRRA
IGNIE-LGIRSWDTNLIECNLDQELKLFVSRHSARFSPEVP-----------GQKILHHR
SDVLETVVLINPSDEAVSTEVRLMITDAARHKLLVLTGQCFENTGELILQSGSFSFQNFI
EIFTDQEIGELLSTTHPANKASLTLFCPEEGDWKNSNLDRHNLQDFINIKLNSASILPEM
EGLSEFTEYLSESVEVPSPFDILEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFNML
INGGSERKSCFWKLIRHLDRVDSILLTHIGDDNLPGINSMLQRKIAELEEEQSQGSTTNS
DWMKNLISPDLGVVFLNVPENLKNPEPNIKMKRSIEEACFTLQYLNKLSMKPEPLFRSVG
NTIDPVILFQKMGVGKLEMYVLNPVKSSKEMQYFMQQW---T-GTN-KDKAE-FILPN-G
QEVD-LPISYL-TSVSS-LIVWHPANPAEKIIRVLFPGNSTQYNILEGLEKLKHLDFLKQ
PLATQKDLTGQVPTPV-VKQTKLKQRADSRESLKPAAKPLPS-KSVRKESKEETPEVTKV
NH-VEKPPKVESKEKVTAKKDK------PVKTETKPSVTEKEVPSK--EEPSPVKAEVAE
K---QATDVKPKAAKEKTVKKETKVKPEDKKEE--KEKPKKEVAKKEDKTPIKKEEKPKK
EEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKEVKKEEKEPKKEIKKLPK
DAKKSSTPLSEAKKPAALKPKVPKKEESVKKDSV-AAGKPKEKGKIKVIKKEGKAAEAVA
A-AV-GTGATTAAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVTKDI
KPQLELIEDEEKLKETEPVEAYVIQKEREVTKGPAESPDEGITTTEGEGECEQTPEELEP
VEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEEHVCVSASKHSPT--
-------ED-EESAKAEADAYI----R-EKRESVASGDDRAEEDMDEAIEKGEAEQSEEE
A--D-EEDKAEDAREEEYEPEK-MEAEDYVMAVVDKAAE-AGGAEEQY-GFLTTPTKQPG
AQSPGREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPM
DEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYSQEYSKPAD---VTPLNGFSEGS
KTDATDGKDYNASASTISPPSSMEEDKFSRSALRDAYCSEVK---ASTTLDIKDTISA--
VSSEKVSPSKSPSLSPSPPSPLEKTPLGERSVNFSLTPNEIKVSAEAEVAP-VSPEVTQE
VVEEHCASPEDKTLEVVSPSQSVTGSAGHTPYYQSPTDEKSSHLPTEVIEKPPAVPVSFE
FSD-AKDENERASVSPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYESFLSADDKASGR
GAESPFEEKSGKQGSPDQVSPVSEMTSTSLYQDKQEGK-STDFAPIKEDFGQEKKTDDVE
AMSSQPALALDERKLG-DVSPTQIDVSQFGSFKEDTKMSISEGTVSDKSATPVDEGVAED
TYSHMEGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTF
QETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQDHRS-EQSSMSIEFGQESPEQSLAM
DFSRQSPDHPTVGAGVLHITENGPTEVDYSPSDMQDSSLSHKIPPMEEP-SYTQDNDLSE
LISVSQVEASPSTSSAHTPSQIASPLQEDTLSDVAPPRDMSLYASLTSEKVQSLEGEKLS
PKSDISPLTPRESSPLYSPTFSDSTSAVKEKTATCHSSS-SPPIDAASAEPYGFRASVLF
DTMQHHLALNRDLSTPGLEK---DSGGKTPGDFSYAYQKPEETTRSPDE-EDYDYESYEK

PF00414 // ENSGT00550000074593_0_Domain_5 (2101, 2117)

TTRTSDVGGYYYEKIERTTKSPSDSGYSYETIGK

PF00414 // ENSGT00550000074593_0_Domain_7 (2135, 2151)

TTKTPEDGDYSYEIIEKTTRTPEEGG
YSYDISEKTTSPPEVSGYSYEKTERS-RRLLDDISNGYDDSEDG

PF00414 // ENSGT00550000074593_0_Domain_12 (2205, 2220)

GHTLGDPSYSYETTEK
ITS-FPESEGYSYETSTK

PF00414 // ENSGT00550000074593_0_Domain_14 (2239, 2256)

TTRTPDTS-TYCYETAE

ENSGT00550000074593_0_Linker_14_15 (2256, 2257)

K

PF00414 // ENSGT00550000074593_0_Domain_15 (2257, 2289)

IARTPQASTYSYETS---------
--------DLC---YTAE--------------KKSPSEARQDVDLCLVSSCEYKHPKTEL
SPSFINPNPLEWFASEEPTEESEKPLTQSGGAPPPPGGKQQGRQCDETPPTSVSESAPSQ
TDSDVPPETEECPSITADANIDSEDESETIPTDKTVTYKHMDPPPAPVQDRSPSPRHPDV
SMVDPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKSDGKSKPLAASPKPAGL
KESSDKVSRVASPKKKESVEKAAKPT-TTPEVK--AARGEEKDKETKNAANASASKSAKT
AT---A-GPGTTKTTKSSAVPPGLPVYLDLCYIPNHSNSKNVDVEFFKRVRSSYYVVSGN
DPAAEEPSRAVLDALLEGKAQWGSNMQVTLIPTHDSEVMREWYQETHEKQQDLNIMVLAS
SSTVVMQDESFPACKIEL

------------------------------------------------------------
------------------------------------------------------------
-----MATVVVEAAEPEPSGGMANPAATTSPSLSHRFLDTKFYLLVVVGEIVTEEHLRRA
IGNIE-LGIRSWDTNLIECNLDQELKLFVSRHSARFSPEVP-----------GQKILHHR
SDVLETVVLINPSDEAVSTEVRLMITDAARHKLLVLTGQCFENTGELILQSGSFSFQNFI
EIFTDQEIGELLSTTHPANKASLTLFCPEEGDWKNSNLDRHNLQDFINIKLNSASILPEM
EGLSEFTEYLSESVEVPSPFDILEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFNML
INGGSERKSCFWKLIRHLDRVDSILLTHIGDDNLPGINSMLQRKIAELEEEQSQGSTTNS
DWMKNLISPDLGVVFLNVPENLKNPEPNIKMKRSTEEACFTLQYLNKLSMKPEPLFRSVG
NTIDPVILFQKMGVGKLEMYVLNPVKNSKEMQYFMQQW---T-GTN-KDKAE-LTLPN-G
QEID-IPISCL-TSVSS-LIVWHPANPAEKIIRVLFPGNSTQYNILEGLEKLKHLDFLKQ
PLATQKDLTGQVATPT-VKQVKLKQRADSRESLKPATKPLPS-KSVRKESKEETPEVTKA
NH-VEKPPKVESKEKVTVKKDK------PVKTETKPPVAEKEVPSK--EEVPPVKAEGAD
K---QGTDVKPKVAKEKTVKKETKAKPEEKKEE--KEKPKKEVAKKEDKTPVKKEEKPKK
EEVKKEVKKEVKKEEKKEVKKEVKKETPLKEAKKEVKKEEKKEIKKEEKEPKKEIKKVPK
DSKKSTTPVSEAKKPAALKPKVPKKEEPVKKESV-AAGKPKEKGKVKVVKKEGKAAEAAV
A-AV-GTVATAAAVAAAAGIATTGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVARDM
KPQLELIEDEEKLKETEPVEAYVIQKETEVIKGPAESPDEGITTTEGEGECEQTPEELEP
VEKQGVDDIEKFEDEGAGFEESSEAGDYEEKAETEEAEEPEEDGEETVCVSTSKHSPV--
-------EEEEESTKAEADVHI----K-EKRESVTSGDDRAEEDMDEAVEKGEAEQSEEE
A--D-EEDRAEDAREEEYEPEK-VEAEDYVMAVVDKAAE-AGGAEDQY-GFLTTSAKPLG
AQSPAREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPM
DEMSTPRDVMSDETNNEETESPSQEFVNITKFESSLYSQEYSKPA----VTSLNGLSEGS
KTDATDGKDYNASASTISPPSSMEEDKFIKSALRDAYCSEEQDVKASATLEIKDTVSA--
VSDEKLSPSKSPSLSPSPPSPIEKTPLGERSVNFSLTPNEIQVSAEAEAVP-VSPEVTQE
VVEEQCASPEEKTLEVVSPSQSVTGSAGHTPYYQSPTEEKSSHLPTEVIEKAPAVPVSFE
FSE-AKDDSERASISPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYDSFLSADDKAPVR
GPESPFEGKNGKQDFPDQISPVSDTTSTGLFQDKQEGK-STDFIPIKEDFGQEKKTDDIE
AMSSQAGLAFDERKLGGDVSPSQIDVSQFGSLKEDTKMSISEGTVSDKSATPVDEGVAED
TYSHMEGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTF
QETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQDHRS-EQSSMSIEFGQESPEHSLAM
DFSRQSPDQPTVGAGMLHITENGPTEVDYSPSDLQDSSLSHKIPPTEEP-SYTQDNDLSE
LISVSQVEASPSTSSAHTPSQIASPLQEDTLSDVVPPRDISLYASLTSEKVQSLEGEKLS
PKSDISPLTPRESSPLYSPSFSDSTSAVKESIAACHTPS-PPPTDAASAEPYGFRASMLF
DTMQHHLALSRDLTTSGVEK---DSGGKTPGDFSYAYQKPEQ

PF00414 // ENSGT00550000074593_0_Domain_4 (2083, 2100)

TTRSPDE-EGYDYESYE

ENSGT00550000074593_0_Linker_4_5 (2100, 2101)

K

PF00414 // ENSGT00550000074593_0_Domain_5 (2101, 2116)

TARTPDVSGYYYEKTDITTKSPSDSSYPYETIEKTTESPEDGGYAYEITGK

PF00414 // ENSGT00550000074593_0_Domain_9 (2152, 2168)

TTRTPEEGG
YSYEISE

ENSGT00550000074593_0_Linker_9_10 (2168, 2169)

K

PF00414 // ENSGT00550000074593_0_Domain_10 (2169, 2185)

TIRTPEVSGYSYEKTERS-RKLLDDISNGYDDSEN

PF00414 // ENSGT00550000074593_0_Domain_12 (2204, 2220)

GGHTLGDSSYSYETTEK
VAS-FPESESYSYETSTATARSPDAP-TYGYETAERIPGTPQASAYAYETS---------
--------DQC---YTAE--------------KKSPSEARQDVDLCLVSSCEYKHPKTEL
SPSFINPNPLEWFASEEPTEESEKPLTQSGAAPPPPGGKPQGRQCDETPPTSVSESAPSQ
TDSDVPPETEECPSITADANIDSEDESETIPTDKTVTYKHMDPPPAPMQDRSPSPRHPDV
SMMDPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKADGKSKPSAASPKPAGL
KESSDKVSRVASPKKKESVEKATKTA-PTPEVK--AARGEEKDKETKNAANTSTSKSVKT
ATA----GPGTTKTAKPSAVPPGPPVYLDLCYIPNHSNSKNVDVEFFKRVRSSYYVVSGN
DPAAEEPSRAVLDALLEGKAQWGSNMQVTLIPTHDSEVMREWYQETHEKQQDLSIMVLAS
SSTVVMQDESFPACKIEL

------------------------------------------------------------
------------------------------------------------------------
-----MATVVVEATEPEPSGSIANPAASTSPSLSHRFLDSKFYLLVVVGETVTEEHLRRA
IGNIE-LGIRSWDTNLIECNLDQELKLFVSRHSARFSPEVP-----------GQKILHHR
SDVLETVVLINPSDEAVSTEVRLMITDAARHKLLVLTGQCFENTGELILQSGSFSFQNFI
EIFTDQEIGELLSTTHPANKASLTLFCPEEGDWKNSNLDRHNLQDFINIKLNSASILPEM
EGLSEFTEYLSESVEVPSPFDILEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFNML
INGGSERKSCFWKLIRHLDRVDSILLTHIGDDNLPGINSMLQRKIAELEEERSQGSTSNS
DWMKNLISPDLGVVFLNVPENLKNPEPNIKMKRSIEEACFTLQYLNKLSMKPEPLFRSVG
NTIEPVILFQKMGVGKLEMYVLNPVKSSKEMQYFMQQW---T-GTN-KDKAE-LILPN-G
QEVD-IPISYL-TSVSS-LIVWHPANPAEKIIRVLFPGNSTQYNILEGLEKLKHLDFLKQ
PLATQKDLTGQVPTPT-VKQVKLKQRADSRESLKPATKPLPS-KSVRKESKEEAPEVTKP
SQ-VEKTPKVESKEKVTVKKDK------PIKTETKPSVTEKEVPSK--EEQSPVKAEVAE
K---QATESKPKVTKEKVVKKEIKAKPEEKKEE--KEKPKREVAKKEDKTPLKKDEKPKK
EEVKKEVKKEIKKEEKKELKKEVKKETPLKEAKKEVKKEEKKEVKKEEKEPKKEIKKISK
DIKK-STPVSETKKPAALKPKVAKKEEATKKEPA-AASKLKDKGKVKVIKKEGKTTEAAA
TAVG-TAATTAAAVAAAGIVA-TGPAKELEAERSLMSSPEDLTKDFEELKAEEIDVAKDI
KPQLELIEDEEKLKETESVEAYVIQKETEVLKGSAESPDEGITTTEGEGECEQTPEELEP
VEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEDNVSGSASKHSPT--
--------EDDESAKAEADVHI----K-EKRESVTSGDDRAEEDMDEALEKEEAEQSEEE
G--EE-EDKAEDAREEDYEPEK-LEGEDYVMAVVDKAAE-AGVAEEQY-GFLSTPTKQPG
AQSPGREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPM
DEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYSQEYSKPI----VASFNGLSEGS
KTDATDGKDYNASASTISPPSSMEEDKFSKSALRDAYCSEEKEVKASAALDI----KD--
VSDERLSPTKSPSLSPSPPSPIEKTPLGERSVNFSLTPNEIKVSAEADVTS-VSPGMTQA
VVEEHCASPEEKTLEVVSPSQSVTGSAGHTPYYQSPTDEKASHLPTEATEKPQAVPVSFE
FSEEAKDENERASISPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYEDFLSADGKALGR
GIKSPFEGKNEKQG----ESPVSEVTSTGLYQEEQEGK-STGFIPIREDFGPEKKTNEVE
IMSSQSALALDERKLGGDVSPTQIDVSQFGSFKEDTKMSISEGTVSDKSATPVDEGVAED
TYSHMEGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTF
QETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQDHRS-EQSSMSIEFGQESPEHSLAM
DFSRQSPDHPTVGASMLHITENGPTEVDYSPSDIQDSSLSHKIPPMEEP-SYTQDNDLSE
LISVSQVEASPSTSSAHTPSQIASPLQEDTLSDVVPPRDMSLYASLTSEKAQSLEGEKLS
PKSDISPLTPRESSPLYSPGFSDSTSATTENAAGR-QTS-SPPMDAASAEPYGFRASMLF
DTMQHHLALNRDLTTSSVEK---DSGGKTPGDFNYAYEKPEKTTRSPDE-EDYDYESYEK
TSRAPDTDGYYYEKTER

PF00414 // ENSGT00550000074593_0_Domain_6 (2118, 2134)

TIKSPCDSGYSYETIEKTIKPQEDGGYACEITEK

PF00414 // ENSGT00550000074593_0_Domain_9 (2152, 2168)

TTRTPEEGG
YSYEISE

ENSGT00550000074593_0_Linker_9_10 (2168, 2169)

K

PF00414 // ENSGT00550000074593_0_Domain_10 (2169, 2185)

TTRTPEVGGYTYEKTERS-RRLLDDISNGYDDSEDGGHTLADCSYSYETTEK
ISS-FPESESYSYEMSTK

PF00414 // ENSGT00550000074593_0_Domain_14 (2239, 2256)

TTRSPDTA-TYCYETME

ENSGT00550000074593_0_Linker_14_15 (2256, 2257)

K

PF00414 // ENSGT00550000074593_0_Domain_15 (2257, 2290)

ITKTPQASTYSYETS---------
--------DRC---YTPE--------------KRSPSEARQDVDLCLVSSCEYKHPKTEL
SPSFINPNPLEWFASEESTEDSEKPLAESGGAPPPSGGKQQGRQCDETPPTSVSESAPSQ
TDSDVPPETEECPSITADANIDSEDESETIPTDKTVTYKHMDPPPAPMQDRSPSPRHPDV
SMVDPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKADGKSKPLAASPKPGAL
KESSDKVSRVASPKKKESVEKATKTT-TTPEIK--ATRGDEKDKETKNAANASASKSAKT
ATA----GPGTTKTAKSSTVPPGLPVYLDLCYIPNHSNSKNVDVEFFKRVRSSYYVVSGN
DPAAEEPSRAVLDALLEGKAQWGSNMQVTLIPTHDSEVMREWYQETHEKQQDLNIMVLAS
SSTVVMQDESFPACKIEL

------------------------------------------------------------
------------------------------------------------------------
-----MATVVVEATEPEPSGSIANPAASTSPSLSHRFLDSKFYLLVVVGEIVTEEHLRRA
IGNIE-LGIRSWDTNLIECNLDQELKLFVSRHSARFSPEVP-----------GQKILHHR
SDVLETVVLINPSDEAVSTEVRLMITDAARHKLLVLTGQCFENTGELILQSGSFSFQNFI
EIFTDQEIGELLSTTHPANKASLTLFCPEEGDWKNSNLDRHNLQDFINIKLNSASILPEM
EGLSEFTEYLSESVEVPSPFDILEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFNML
INGGSERKSCFWKLIRHLDRVDSILLTHIGDDNLPGINSMLQRKIAELEEEQSQGSTTNS
DWMKNLISPDLGVVFLNVPENLKNPEPNIKMKRSIEEACFTLQYLNKLSMKPEPLFRSVG
NTIDPVILFQKMGVGKLEMYVLNPVKSSKEMQYFMQQW---T-GTN-KDKAE-LILPN-G
QEVD-LPISYL-TSVSS-LIVWHPANPVEKIIRVLFPGNSTQYNILEGLEKLKHLDFLKQ
PLATQKDLTGQVPTPV-VKQTKLKQRADSRESLKPATKPLPS-KSVRKESKEETPEVTKV
NQ-VEKPPKVESKEKVTVKKDK------PVKTETKPSVTEKEVPSK--EEPSPVKAEVAE
K---QATDVKPKAAKEKTVKKETKAKPEDKKEE--KEKPKKEVAKKEDKTPIKKEEKTKK
EEVKKEVKKEIKKEEKKEPKKEVKKETPLKEAKKEVKKEEKKEVKKEEKEPKKEIKKLPK
DAKKSSTPLSEAKKPAALKPKVPKKEEPVKKDSV-AAGKPKEKGKIKVVKKEGKATEAVA
A-AV-GTGAATAAVVAAAGIVATGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVTKDI
KPQLELIEDEEKLKETEPVEAYVIQKETEVTKGPAESPDEGITTTEGEGECEQTPEELEP
VEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEEHICVSASKHSPT--
-------ED-EESAKAEADAYI----R-EKRESVASGDDRAEEDMDEAIEKGEAEQSEEE
A--D-EEDKAEDAREEEYEPEK-MEAEDYVMAVVDKAAE-AGGAEEQY-GFLTTPTKQPG
AQSPGREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPM
DEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYSQEYSKPAD---VTPLNGFSEGS
KTDATDGKDYNASASTISPPSSMEEDKFSRSALRDAYCSEVKA---STTLDIKDTISA--
VSGEKLSPSKSPSLSPSPPSPLEKTPLGERSVNFSLTPNEIKVSAEAEVAP-VSPEVTQE
VVEEHCASPEDKTLEVVSPSQSVTGSAGHTPYYQSPTDEKSSHLPTEVIEKPPAVPVSFE
FSD-AKDESERASVSPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYESFLSADDKASGR
GAESPFEEKSEKQGSPDQVSPVSEMTSTSLYQDKQEGK-STDFVPIKEDFGQEKKTDDVE
ATSSQPALALDERKLG-DVSPTQIDVSQFGSFKEDTKMSISEGTVSDKSATPVDEGVAED
TYSHMEGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTF
QETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQDHRS-EQSSMSIEFGQESPEHSLAM
DFSRQSPDHPTVGAGVLHITENGPTEVDYSPSDMQDSSLSHKIPPMEEP-SYTQDNDLSE
LISVSQVEASPSTSSAHTPSQIASPLQEDTLSDVAPPRDMSLYASLTSEKVQSLEGEKLS
PKSDISPLTPRESSPLYSPAFSDSTSAVKDKTAACHTSS-SPPIDAASAEPYGFRASVLF
DTMQHHLALNRDLATPGLEK---DSGGKTPGDFSYAYQKPEKTTRSPDE-EDYDYESYEK

PF00414 // ENSGT00550000074593_0_Domain_5 (2101, 2117)

TTRTSDVGGYYYEKIERTTKSPSDSGYSYETIGK

PF00414 // ENSGT00550000074593_0_Domain_7 (2135, 2151)

TTKTPEDGDYSYEIIEKTTRTPEEGG
YSYDISEKTTSPPEVSGYSYEKTERS-RRLLDDISNGYDDSEDG

PF00414 // ENSGT00550000074593_0_Domain_12 (2205, 2220)

GHTLGDPSYSYETTEK
ITG-FPESESYSYETAKK

PF00414 // ENSGT00550000074593_0_Domain_14 (2239, 2256)

TTLTPDTS-TYCYETTE

ENSGT00550000074593_0_Linker_14_15 (2256, 2257)

K

PF00414 // ENSGT00550000074593_0_Domain_15 (2257, 2289)

ITRTPQASTYSYETS---------
--------DLC---YTAE--------------KKSPSEARQDVDLCLVSSCEYKHPKTEL
SPSFINPNPLEWFASEEPTEESEKPLTQSGGAPPPPGGKQQGRQCDETPPTSVSESAPSQ
TDSDVPPETEECPSITADANIDSEDESETIPTDKTVTYKHMDPPPAPVQDRSPSPRHPDV
SMVDPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKSDGKSKPLAASPKPGGL
KESSDKVSRVASPKKKESVEKAAKPT-TTPEVK--TARGEEKDKETKNAANASASKSAKT
AT---A-GPGNTKATKSSTVPPGLPVYLDLCYIPNHSNSKNVDVEFFKRVRSSYYVVSGN
DPAAEEPSRAVLDALLEGKAQWGSNMQVTLIPTHDSEVMREWYQETHEKQQDLNIMVLAS
SSTVVMQDESFPACKIEL

------------------------------------------------------------
------------------------------------------------------------
-----MATVVVEATEPEPSGSIANPAASTSPSLSHRFLDSKFYLLVVVGEIVTEEHLRRA
IGNIE-LGIRSWDTNLIECNLDQELKLFVSRHSARFSPEVP-----------GQKILHHR
SDVLETVVLINPSDEAVSTEVRLMITDAARHKLLVLTGQCFENTGELILQSGSFSFQNFI
EIFTDQEIGELLSTTHPANKASLTLFCPEEGDWKNSNLDRHNLQDFINIKLNSASILPEM
EGLSEFTEYLSESVEVPSPFDILEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFNML
INGGSERKSCFWKLIRHLDRVDSILLTHIGDDNLPGINSMLQRKIAELEEEQSQGSTTNS
DWMKNLISPDLGVVFLNVPENLKNPEPNIKMKRSIEEACFTLQYLNKLSMKPEPLFRSVG
NTIDPVILFQKMGVGKLEMYVLNPVKSSKEMQYFMQQW---T-GTN-KDKAE-LILPN-G
QEVD-LPISYL-TSVSS-LIVWHPANPAEKIIRVLFPGNSTQYNILEGLEKLKHLDFLKQ
PLATQKDLTGQVPTPV-VKQTKLKQRADSRESLKPATKPLPS-KSVRKESKEETPEVTKV
NH-VEKPPKVESKEKVTVKKDK------PVKTETKPSVTEKEVPSK--EEPSPVKAEVAE
K---QATDVKPKAAKEKTVKKETKAKPEDKKEE--KEKPKKEVAKKEDKTPIKKEEKPKK
EEVKKEVKKEIKKEEKKEPKKEVKKETPLKEAKKEVKKEEKKEVKKEEKEPKKEIKKLPK
DAKKSSTPLSEAKKPAALKPKVPKKEEPVKKDSV-AAGKPKEKGKIKVIKKEGKATEAVA
A-AV-GTGAA---VVAAAGIAATGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVTKDI
KPQLELIEDEEKLKETEPVEAYVIQKETEVTKGPAESPDEGITTTEGEGECEQTPEELEP
VEKHGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEEHICVSASKHSPT--
-------ED-EESAKAEADAYI----R-EKRESVASGDDRAEEDMDEAIEKGEAEQSEEE
A--D-EEDKAEDAREEEYEPEK-MEAEDYVMAVVDKAAE-AGGAEEQY-GFLTTPTKQPG
AQSPGREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPM
DEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYSQEYTKPAD---VTPLNGFSEGS
KTDATDGKDYNASASTISPPSSMEEDKFSRSALRDAYCSEVKA---STTLDIKDTISA--
VSGEKLSPSKSPSLSPSPPSPLEKTPLGERSVNFSLTPNEIKVSAEAEVAP-VSPEVTQE
VVEEHCASPEDKTLEVVSPSQSVTGSAGHTPYYQSPTDEKSSHLPTEVIEKPPAVPVSFE
FSD-AKDESERASVSPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYESFLSADDKASGR
GAESPFEEKSEKQGSPDQVSPVSEMTSTSLYQDKQEGK-STDFVPIKEDFGQEKKTDDVE
ATSSQPALALDERKLG-DVSPTQIDVSQFGSFKEDTKMSISEGTVSDKSATPVDEGVAED
TYSHMEGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTF
QETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQDHRS-EQSSMSIEFGQESPEHSLAM
DFSRQSPDHPTVGAGVLHITENGPTEVDYSPSDMQDSSLSHKIPPMEEP-SYTQDNDLSE
LISVSQVEASPSTSSAHTPSQIASPLQEDTLSDVAPPRDMSLYASLTSEKVQSLEGEKLS
PKSDISPLTPRESSPLYSPTFSDSTSAVKEKIAVCHTSS-SPPIDAASAEPYGFRASVLF
DTMQHHLALNRDLATPGLEK---DSGGKTPGDFSYAYQKPEKTTRSPDE-EDYDYESYEK

PF00414 // ENSGT00550000074593_0_Domain_5 (2101, 2117)

TTRTSDVGGYYYEKIERTTKSPSDSGYSYETIGK

PF00414 // ENSGT00550000074593_0_Domain_7 (2135, 2151)

TTKTPEDGDYSYEIIEKTTRTPEEGG
YSYDISEKTTSPPEVSGYSYEKTERS-RRLLDDISNGYDDSEDG

PF00414 // ENSGT00550000074593_0_Domain_12 (2205, 2220)

GHTLGDPSYSYETTEK
ITG-FPESESYSYETAKK

PF00414 // ENSGT00550000074593_0_Domain_14 (2239, 2256)

TTLTPDTS-TYCYETTE

ENSGT00550000074593_0_Linker_14_15 (2256, 2257)

K

PF00414 // ENSGT00550000074593_0_Domain_15 (2257, 2289)

ITRTPQASTYSYETS---------
--------DLC---YTAE--------------KKSPSEARQDVDLCLVSSCEYKHPKTEL
SPSFINPNPLEWFASEEPTEESEKPLTQSGGAPPPPGGKQQGRQCDETPPTSVSESAPSQ
TDSDVPPETEECPSITADANIDSEDESETIPTDKTVTYKHMDPPPAPVQDRSPSPRHPDV
SMVDPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKSDGKSKPLAASPKPGGL
KESSDKVSRVASPKKKESVEKAAKPT-TTPEVK--TARGEEKDKETKNAANASASKSAKT
AT---A-GPGTTKATKSSTVPPGLPVYLDLCYIPNHSNSKNVDVEFFKRVRSSYYVVSGN
DPAAEEPSRAVLDALLEGKAQWGSNMQVTLIPTHDSEVMREWYQETHEKQQDLNIMVLAS
SSTVVMQDESFPACKIEL

------------------------------------------------------------
------------------------------------------------------------
-----MATVVVEATEPEPSGSIGNPVASTSPSLSHRFLDSKFYLLVVVGETVTEEHLRRA
IGNIE-LGIRSWDTNLIECNLDQELKLFVSRHSARFSPEVP-----------GQKILHHR
SDVLETVVLINPSDEAVSTEVRLMITDAARHKLLVLTGQCFENTGELILQSGSFSFQNFI
EIFTDQEIGELLSTTHPANKASLTLFCPEEGDWKNSNLDRHNLQDFINIKLNSASILPEM
EGLSEFTEYLSESVEVPSPFDILEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFNML
INGGSERKSCFWKLIRHLDRVDSILLTHIGDDNLPGINSMLQRKIAELEEERSQGSTSNS
DWMKNLISPDLGVVFLNVPENLKDPEPNVKMKRSIEEACFTLQYLNKLSMKPEPLFRSVG
NAIEPVILFQKMGVGKLEMYVLNPVKSSKEMQYFMQQW---T-GTN-KDKAE-LILPN-G
QEVD-IPISYL-TSVSS-LIVWHPANPAEKIIRVLFPGNSTQYNILEGLEKLKHLDFLKQ
PLATQKDLTGQVPTPP-VKQVKLKQRADSRESLKPAAKPLTS-KSVRKESKEETPEVTKA
SQ-VEKTPKVESKEKVIVKKDK------PVKTESKPSVTEKEVSSK--EEQSPVKAEVAE
K---QAAESKPKVTKDKVVKKESKTKLEEKKE----EKPKKEVVKKEDKTPLKKDEKPKK
EEVKKEIKKDIKKEEKRELKKEVKKETPLKDAKKELKKEEKKEVKKEEKEPKKEIKKISK
DIKK-STPLSDTKKPSALKPKVAKKEESTKKEPI-AAGKLKDKGKVKVIKKEGKTTEAAA
TAVG-TAATTAAAVAAA-GIAASGPAKELEAERSLMSSPEDLTKDFEELKAEEIDVAKDI
KPQLELIEDEEKLKETQPGEAYVIQKETEVSKGSAESPDEGITTTEGEGECEQTPEELEP
VEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEDNASGSASKHSPT--
--------EDDESAKAEADVHL----K-EKRESVVSGDDRAEEDMDEMLEKGEAEQSEEE
G--EE-EDKAEDAREEDYEPDK-AEAEDYVMAVADKAAE-AGVTEEQY-GFLGTSAKQPG
IQSPSREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPM
DEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYSQEYSKPA----VASFNGLSEGS
KTDATDGKDYNASASTISPPSSMEEDKFSKSALRDAYCSEEKEVKASAELDI----KD--
VSDERLSPAKSPSQSPSPPSPIEKTPLGERSVNFSLTPNEIKVSAEGEARS-VSPGVTQA
IVEEHCASPEEKTLEVVSPSQSVTGSAGHTPYYQSPTDEKSSHLPTEVTEKPQAVPVSFE
FSE-AKDENERASLSPMDEPVPDSESPVEKVMSPLRSPPLLGSESPYEDFLSADSKALGR
RSESPFEGKNGKQGFPDRESPVSDLTSTGLYQDKREEKSTTGFIPIKEDFGPEKKASDVE
TMSSQTALALDERKLGGDVSPTQIDVSQFGSFKEDTKMSISEGTVSDKSATPVDEGVAED
TYSHMEGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTF
QETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQDHRS-EQSSMSIEFGQESPEHSLAM
DFSRQSPDHPTLGASMLHITENGPTEVDYSPSDIQDSSLSHKIPPTEEP-SYTQDNDLSE
LISVSQVEASPSTSSAHTPSQIASPLQEDTLSDVVPPREMSLYASLASENVQSLEGGKLS
PKSDISPLTPRESSPLYSPGFSDSTSAAKETAAAHQAPS-SPPIDAATAEPYGFRSSMLF
DTMQHHLALNRDLTTSSMEK---DGGGKTPGDFNYAYQKPENATGSPDE-EDYDYESQEK

PF00414 // ENSGT00550000074593_0_Domain_5 (2101, 2117)

TIRTHDVGGYYYEKTE

ENSGT00550000074593_0_Linker_5_6 (2117, 2118)

R

PF00414 // ENSGT00550000074593_0_Domain_6 (2118, 2134)

TIRSPCDSGYSYETIEKTTKTPEDGGYTCEITEK

PF00414 // ENSGT00550000074593_0_Domain_9 (2152, 2168)

TTRTPEEGG
YSYEISE

ENSGT00550000074593_0_Linker_9_10 (2168, 2169)

K

PF00414 // ENSGT00550000074593_0_Domain_10 (2169, 2185)

TTRTPEVSGYTYEKTERS-RRLLDDISNGYDDTEDGGHTLGDCSYSYETTEK
MTS-FPESESYSYETSTK

PF00414 // ENSGT00550000074593_0_Domain_14 (2239, 2256)

TTRSPDTS-AYCYETME

ENSGT00550000074593_0_Linker_14_15 (2256, 2257)

K

PF00414 // ENSGT00550000074593_0_Domain_15 (2257, 2290)

ITKTPQASTYSYETS---------
--------DRC---YSTE--------------KKSPSEARQDVDLCLVSSCEFKHPKTEL
SPSFINPNPLEWFAGEEPTEESEKPLTQSGGAPPPSGGKQQGRQCDETPPTSVSESAPSQ
TDSDVPPETEECPSITADANIDSEDESETIPTDKTVTYKHMDPPPAPMQDRSPSPRHPDV
SMVDPDALAIDQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKGDGKSKPLAASPKPGAL
KESSDKVSRVASPKKKESVEKATKTT-TTPEVK--ATRGEEKDKETKNAANASASKSVKT
ATA----GPGTTKTVKSSTVPPGLPVYLDLCYIPNHSNSKNVDVEFFKRVRSSYYVVSGN
DPAAEEPSRAVLDALLEGKAQWGSNMQVTLIPTHDSEVMREWYQETHEKQQDLNIMVLAS
SSTVVMQDESFPACKIEL

------------------------------------------------------------
------------------------------------------------------------
-----MATVVVEATEPEPSGSIANPSASTSPSLSHRFLDSKFYLLVVIGETVTEEHLRRA
IGTIE-LGIRSWDTNLIECNLDQELKLFVSRHSARFSPEVP-----------GQKILHHR
SDVLETVVLINPSDEAVSTEVRLMITDAARHKLLVLTGQCFENTGELILQSGSFSFQNFI
EIFTDQEIGELLSTTHPANKASLTLFCPEEGDWKNSNLDRHNLQDFINIKLNSASILPEM
EGLSEFTEYLSESVEVPSPFDILEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFNML
INGGSERKSCFWKLIRHLDRVDSILLTHIGDDNLPGINSMLQRKIAELEEEQSQGSTTNS
DWMKNLISPDLGVVFLNVPENLKNPEPNIKMKRSIEEACFTLQYLNKLSMKPEPLFRSVG
NTIEPVILFQKMGVGKLEMYVLNPVKSSKEMQYFLQQW---T-GTN-KDKAE-LILPS-G
QEVD-IPISYL-TSVSS-LIVWHPANPAEKIIRVLFPGNSTQYNILEGLEKLKHLDFLKQ
PLATQKDLTGQVPTPTTTKQVKLKQRADSRESLKPAAKPLTT-KSVRKESKEETPDVTKA
SQ-VEKPPKVESKEKVMVKKDK------PVKTETKPPVTEKEIASK--EELPPARAEVAE
K---QATDVKPKISKEKVVKKETKPKSEEKKEE--KEKPKKEVAKKEEKTLIKKEEKPKK
EEVKREVKKEIKKEEKKELKKEVKKETPLKDAKKEIKKEEKKEIKKDEKEPKKEIKKLSK
DSKKSTTLLSEAKKPAALKPKVPKKEETVKKE-SVAAGKPKEKGKIKVIKKESKTSEAAA
I-GT-VVTTAAA--VAAAGIAATGPAKELEAERSLMSSPEDLTKDFEELKAEEIDVAKDI
KPQLELTEDEEKVKETEPVEAYVIQKETEVIKGPAESPDEGITTTEGEGECEQTPEELEP
VEKQGVDDIEKYEDEGAGFEESSETGDYEEKAETEEAEEPEEDSEENVCVSTSKHSPI--
--------DEEESAKAEADVHI----K-EKRESVASGDDRAEEDMDEAVEKGEAELSEEE
GE---EEDKAEDAREEEYEPEK-AEAEDYVMAVVDK-AAEVSGTEDQY-GFLATSTKQPG
AQSPGRGPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPM
DEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYSQEYTKPG----AAPFNGLSDGS
KTDATEGKDYNVSASTISPPSSMEEDKFTRSALRDAYCPEEKEVKASATLEIQDTTSA--
VSDERLSPAKSPSLSPSPPSPIEKTPLGERSVNFSLTPNEIKVSTEAEAVS-VSPEVTQE
IVEEHCASPEEKTLEVVSPSQSVTGSAGHTPYYQSPTDEKSSHLPTEVIEKPQAVPVSFE
FSDAKDESER-ASISPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYESFLSVDDKAPSR
GSESPFEGKNGKQSFPDQISPVSETTSTGLYQDKQEGK-STDFIPIKEDFSLEKKTDDVE
ALSSHAALALDERKLG-DVSPTQTDVIQFGSFKEDTKMSISEGTVSDKSATPVDEGVAED
TYSHMEGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTF
QETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQDHRS-EQSSMSIEFGQESPEHSLAM
DFSRQSPDHPTVGASVLHITENGPTEVDYSP-DMQDSSLSHKIPPTEEP-SYTQDNDLSE
LISVSQVEASPSTSSAHTPSQIASPLQEDTLSDVAPPRDMSLYASLTSEKVQSLEREKLS
PKSDISPLTPRESSPLYSPGFSDSTSAVKENVA-ACHTSSSPPVDAASSEPYGFRASMLF
DTMQHHLTLNRDLTTSGIED---SGG-KTPGDFGYAYQKPEKTTRSPDEEEDYDYESYEK
S

PF00414 // ENSGT00550000074593_0_Domain_5 (2102, 2117)

TRTPDVGSYYYEKTE

ENSGT00550000074593_0_Linker_5_6 (2117, 2120)

RTL

PF00414 // ENSGT00550000074593_0_Domain_6 (2120, 2134)

KSPCDSGYSYETIEK-TKTPEDGGYACEITEK

PF00414 // ENSGT00550000074593_0_Domain_9 (2152, 2168)

TTRTPEEGG
YSYEISE

ENSGT00550000074593_0_Linker_9_10 (2168, 2169)

K

PF00414 // ENSGT00550000074593_0_Domain_10 (2169, 2185)

TIRTPDVSGYSYEVTERS-RRLLDDISNGYDDSEDVGRTIGDSSYSFETTEK
ITS-FPECESYSYETSTKM

PF00414 // ENSGT00550000074593_0_Domain_14 (2240, 2256)

TRSPDSS-TYCYETME

ENSGT00550000074593_0_Linker_14_15 (2256, 2257)

K

PF00414 // ENSGT00550000074593_0_Domain_15 (2257, 2290)

ITKTPQASAYSYETS---------
--------DRC---YSTE--------------KKCPSEARQEVDLCLVSSCEYKHPKTEL
SPSFINPNPLEWFASEEPTEESEKPLTQLGGAPPPPGGKQQGRQCDETPPTSVSESAPSQ
TDSDVPPETEECPSITADANIDSEDESETIPTDKTVTYKHMDPPPAPMQDRSPSPRHPDV
TMVDPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSSPIKKGDGKSKPLAASPKPGAL
KETSDKVSRVASPKKKEAVEKATKTT-STPEVK--AARGEEKDKETKNAAN--VSKSVKT
AT----PGLGTTKTAKSSTVPPGLPVYLDLCYIPNHSNSKNVDVEFFKRVRSSYYVVSGN
DPAAEEPSRAVLDALLEGKAQWGSNMQVTLIPTHDSEVMREWYQETHEKQQDLNIMVLAS
SSTVVMQDESFPACKIEL

------------------------------------------------------------
------------------------------------------------------------
-----MATVVVEATEPEPSGSIANPAASTSPSLSHRFLDSKFYLLVVVGETVTEEHLRRA
IGNIE-LGIRSWDTNLIECNLDQELKLFVSRHSARFSPEVP-----------GQKILHHR
SDILETVVLINPSDEAVSTEVRLMITDAARHKLLVLTGQCFENTGELILQSGSFSFQNFI
EIFTDQEIGELLSTTHPANKASLTLFCPEEGDWKNSNLDRHNLQDFINIKLNSACILPEM
EGLSEFTEYLSESVEVPSPFDILEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFNML
INGGSERKSCFWKLIRHLDRVDSILLTHIGDDNLPGINSMLQRKIAELEEEQSQGSTTNS
DWMKNLISPDLGVVFLNVPENLKNPEPNIKMKRSIEEACFTLQYLNKLSMKPEPLFRSVG
NTIEPVILFQKMGVGKLEMYVLNPVKSSKEMQYFLQQW---T-GTS-KDKAE-LILPS-G
QEVD-IPISYL-TSVSS-LIVWHPANPAEKIIRVLFPGNSTQYNILEGLEKLKHLDFLKQ
PLATQKDLTGQVPTPTTAKQVKLKQRADSRESLKPAAKPLPT-KSVRKESKEETPDVTKA
NQ-VEKPPKVESKEKVVVKKDK------PIKTETKPPVTEKEVASK--EEQPPAKAEVAE
K---QATDVKPKVAKEKVVKKDVKPKPEEKKED--KEKPKKEVVKKEEKTPIKKEEKLKK
EEVKKEVKKEIKKEEKKELKKEVKKETPLKEAKKEVKKEEKKEIKKEEKEPKKEIKKLPK
DSKKSTTPVSEAKKPAALKPKVSKKEEPVKKESAVAAGKPKEKGKIKVIKKEGKVSEAAA
T-AA-VATTAAA--VAAAGIVATGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVVKDI
KPQLELTEDEEKEKETEPVEAYVVQKETEVIKGPAESPDEGITTTEGEGECEQTPEELEP
VEKQGVDDIEKYEDEGAGFEESSETGDYEEKAETEEAEEPEEDSEENVCVSTSKHSPI--
--------DDEESAKAEADVHI----E-EKRGSVASGDDRAEEDMDEAVEKGEAEMSEEE
GE----EDKAEDAREEEYEPEK-AEAEDYVMAVVDK-AAEAGG-TDQY-AFLATSAKQPG
AQSPGREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPM
DEMSTPRDVMSDETNNEETESPSQEFVNITKYESALYSQESAKPA----VTPFNGLSDGS
KTDATEGKDYSVSASTISPPSSMEEDKFTKSALRDAYYSEEKELKPSGTLEVQDTTSA--
VSDERLSPAKSPSLSPSPPSPIEKTPLGERSVNFSLTPNEIKVSTEVEAVS-VSPEVTRE
VVEEHCASPEEKTLEVVSPSQSVTGSAGHTPYYQSPTDEKATHLPTEVIEKPQAVPVSFE
FSDAKDENER-ASVSPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYESFLSVDDKPPSR
GSESPFEGKDGKQSLSDRVSPVSEMTSTGLYLDKQEGK-STDFVPIKEDLSPEKKMDDVE
AMSSHAALALDERKLG-DVSPTQIDAIQFGSFKEDTKMSISEGTVSDKSATPVDEGVAED
TYSHMEGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTF
QETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQDHRS-EQSSMSIEFGQESPEHSLAM
DFSRQSPDHPTVGASVLHITENGPTEVDYSPSDIQDSSLSHKIPPTEEP-SYTQDNDLSE
LISVSQVEASPSTSSAHTPSQIASPLQEDTLSDVAPPRDMTLYASLTSEKVQSLEAEKLS
PKSDISPLTPRESSPSYSPGFSDSTSAVKESSAAAHHIASSPPVDPASTEPYSFRASMLL
DTMQHHLTLDRDLSTSGIED---SGG-KIPGDFSYAYQKPEKTTRSPDE-EDYDYESYGK

PF00414 // ENSGT00550000074593_0_Domain_5 (2101, 2116)

TTRTPDVGSYYYEKT

ENSGT00550000074593_0_Linker_5_6 (2116, 2120)

EGTM

PF00414 // ENSGT00550000074593_0_Domain_6 (2120, 2134)

KSPCDSGYSYETTEK-TKTPEDDGYACEITEK

PF00414 // ENSGT00550000074593_0_Domain_9 (2152, 2168)

TTRSPEESG
YSYEISEKTIRTPEVSGYSYQVTERS-RRLLDDISNGYDDSEDG

PF00414 // ENSGT00550000074593_0_Domain_12 (2205, 2220)

GHTLGDSSYSYETTEK
IPS-FPESESYSYEMSTK

PF00414 // ENSGT00550000074593_0_Domain_14 (2239, 2256)

TTRSPDSS-TYCYETME

ENSGT00550000074593_0_Linker_14_15 (2256, 2257)

K

PF00414 // ENSGT00550000074593_0_Domain_15 (2257, 2290)

ITKTPQASAYSYETS---------
--------DRC---YSAE--------------KKSPSEARQEVDLCLVSSCEYKHPKTEL
SPSFINPNPLEWFASEESTEESEKPLTQSGGAPPPPGGKQQGRQCDETPPTSVSESAPSQ
TDSDVPPETEECPSITADANIDSEDESETIPTDKTVTYKHMDPPPAPMQDRSPSPRHPDV
TMVDPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKGDGKSKPSAASPKPGPL
KEPSDKVSRVASPKKKESVEKATKPT-TTPEVK--AARGEEKDKETKNAAN--VSKSVKT
AT----AGPGTTKTTKSSSVPPGLPVYLDLCYIPNHSNSKNVDVEFFKRVRSSYYVVSGN
DPAAEEPSRAVLDALLEGKSQWGSNMQVTLIPTHDSEVMREWYQETHEKQQDLNIMVLAS
SSTVVMQDESFPACKIEL

------------------------------------------------------------
------------------------------------------------------------
-----MATVVVEAAEPEPSGSIANPAATTSPSLSHRFLDSKFYLLVVVGEIVTEEHLRRA
IGNIE-LGIRSWDTNLIECNLDQELKLFVSRHSARFSPEVP-----------GQKILHHR
SDVLETVVLINPSDEAVSTEVRLMITDAARHKLLVLTGQCFENTGELILQSGSFSFQNFI
EIFTDQEIGELLSTTHPANKASLTLFCPEEGDWKNSNLDRHNLQDFINIKLNSASILPEM
EGLSEFTEYLSESVEVPSPFDILEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFNML
INGGSERKSCFWKLIRHLDRVDSILLTHIGDDNLPGINSMLQRKIAELEEEQSQGSTTNS
DWMKNLISPDLGVVFLNVPENLKNPEPNIKMKRSIEEACFTLQYLNKLSMKPEPLFRSVG
NTIDPVILFQKMGVGKLEMYVLNPVKSSKEMQYFMQQW---T-GTN-KDKAE-LILPN-G
QEID-IPISYL-TSVSS-LIVWHPANPAEKIIRVLFPGNSTQYNILEGLEKLKHLDFLKQ
PLATQKDLTGQVATPA-VKQVKLKQRADSRESLKPAAKPLPS-KTVRKESKEETPEVTK-
-G-LEKAPKVESKEKVTVKKDK------PVKTETKPPVTEKETPSK--EELPPAKAEGAE
K---QGTDVKPKVAKEKTVKKETKPKAEEKKEEKEKEKPKKEVAKKEDKTPVKKEEKPKK
EEVKKEVKKEIKKEEKKEIKKEVKKETPLKEAKKEVKKEEKKEIKKEEKEPKKEIKKLPK
DTKKSPTPVAEAKKPAALKPKVPKKEEPVKKEAV-AAGKPKEKGKIKVVKKEGKTAEAAA
A-AL-GTVAAAA---AVAGLATTGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVAKDI
KPQLELIEDEEKLKQTEPVEAYVIQKETEVIKGPAESPDEGITTTEGEGECEQTPEELEP
VEKQGVEDTEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDAEDHVRVSTSKHSLA--
-------EE-EESAKAEADAHV----K-EKRESVASGDDRAEEDMDEALEKGEAEQSEEE
A--E-EEDRAEDAREEDYEPEK-AEAEDYVRAVVDKAA------EAQY-GFLTMAPKPVG
AQSPVQEPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPM
DEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYSQEYAKP-A---VTSLNGLSDGS
KTDATDGRDYNASASTISPPSSMEEDKFSRSALREAYYSEEKDVRAGATLEIKDTVSP--
VLDEKLSPPKSPSLSPSPPSPIEKTPLGERSVNFSLTPNEIKVSAEAEVVP-VSPEVTQE
VVEEHCASPEDKTLEVVSPSQSVTGSAGHTPYYQSPTEEKSSHLPTEVIEKPAAVPVSFE
FSD-AKDESERASISPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYESFLSADGKAPGR
GTESPFEGKDEKEASPDQISPVSDMTSTGLFQDKQEGK-STDFIPIKEDFGQEKKTDDVE
DMSSQAGLTLDERKLGGDVSPTQIDVSQFGSLKEDTKMSISEGTVSDKSATPVDEGVVED
TYSHMEGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTF
QETEMSPSKEECPRPMSISPPDFSPKTAKSQTPVQDHRS-EQSSMSIEFGQESPEHSLAM
DFSRQSPDHPTVGAGMLHITENGPTEVDYSPSDMQDSSLSHKIPPTEEP-SYTQDNDLSE
LISVSQVEASPSTSSAHTPSQIASPLQEDTLSDAVPPRDISLYASLTSEKVQSLDAEKLS
PKSDISPLTPRESSPLYSPSLSDSTSAVKDSTAACHTAS-PPPMDAASAEPYGFRASMLF
DTMPHHLALNRDLTTPGMEE---DTGGKTPGDFSYAYEKPETTTRSPDE-EGYDYEAYEK

PF00414 // ENSGT00550000074593_0_Domain_5 (2101, 2116)

TTRTPDVSGYYYEKT

ENSGT00550000074593_0_Linker_5_6 (2116, 2119)

ESV

PF00414 // ENSGT00550000074593_0_Domain_6 (2119, 2134)

TKSPCDSSYSYETMEKTSKSPEDGGYAYEITEKTTRSPEESG
YAYEISEK

PF00414 // ENSGT00550000074593_0_Domain_10 (2169, 2185)

TIRTPEVSAYSYEKAERS-RRLLDDISNGYDDSEE

PF00414 // ENSGT00550000074593_0_Domain_12 (2204, 2220)

GGHTLGDSSYSYETTEK
TAG-FPESESYSYETSTTTTRSPDAS-AYCYETPEKITRAPQVSSYAYETS---------
--------DQC---YTAE--------------KKSPSEARQDVDLCLVSSCEYKHPKTEL
SPSFINPNPLEWFASEEPTEESEKPLTQSGGAPPPPGGKPQGRQCDETPPTSVSESAPSQ
TDSDVPPETEECPSITADANIDSEDESETIPTDKTVTYKHMDPPPAPMQDRSPSPRHPDV
SMMDPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKGDGKSKPSAASPKPGAL
KESSDKVSKVASPKKKESVEKATKTT-TTPEVK--AARGEEKDKETKNAANASTSKSVKT
ATAVYK-GPGTTKTSKPSAVPPGPPVYLDLCYIPNHSNSKNVDVEFFKRVRSSYYVVSGN
DPAAEEPSRAVLDALLEGKAQWGSNMQVTLIPTHDSEVMREWYQETHEKQQDLNIMVLAS
SSTVVMQDESFPACKIEL

MTSASGQRLEERRQPPREDVPGGPFLLLFLLLPGS-------LPS--LHIKAAPPPRPLS
LPAPLRRALSAALGEGGGGGGARRQRRGDAGGGAETAPSEIILSPAAEERSGRSETLRPG
TAAGRMATVVVEATEPEPSGSIANPAASTSPSLSHRFLDSKFYLLVVVGEIVTEEHLRRA
IGNIE-LGIRSWDTNLIECNLDQELKLFVSRHSARFSPEVP-----------GQKILHHR
SDVLETVVLINPSDEAVSTEVRLMITDAARHKLLVLTGQCFENTGELILQSGSFSFQNFI
EIFTDQEIGELLSTTHPANKASLTLFCPEEGDWKNSNLDRHNLQDFINIKLNSASILPEM
EGLSEFTEYLSESVEVPSPFDILEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFNML
INGGSERKSCFWKLIRHLDRVDSILLTHIGDDNLPGINSMLQRKIAELEEEQSQGSTTNS
DWMKNLISPDLGVVFLNVPENLKNPEPNIKMKRSIEEACFTLQYLNKLSMRPEPLFRSVG
NTIDPVILFQKMGVGKLEMYVLNPVKSSKEMQYFMQQW---T-GTN-KDKAE-LILPN-G
QEVD-LPISYL-TSVSS-LIVWHPANPAEKIIRVLFPGNSTQYNILEGLEKLKHLDFLKQ
PLATQKDLTGQVPTPV-VKQTKLKQRADSRESLKPATKPLPS-KSVRKESKEETPEVTKV
NH-VEKPPKVESKEKVTVKKDK------PVKTETKPSVTEKEVPSK--EEPSPVKAEVAE
K---QATDVKPKAAKEKTVKKETKAKPEDKKEE--KEKPKKEVAKKEDKTPIKKEEKPKK
EEVKKEVKKEIKKEEKKEPKKEVKKETPLKEAKKEVKKEEKKEVKKEEKEPKKEIKKLPK
DAKKSSTPLSEAKKPAALKPKVPKKEEPVKKDSV-AAGKPKEKGKIKVIKKEGKATEAVA
A-AV-GTGAATAAVVAAAGIAATGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVTKDI
KPQLELIEDEEKLKETEPVEAYVIQKETEVTKGPAESPDEGITTTEGEGECEQTPEELEP
VEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEEHICVSASKHSPT--
-------E-YEESAKAEADAYI----R-EKRESVASGDDRAEEDMDEAIEKGEAEQSEEE
A--D-EEDKAEDAREEEYEPEK-MEAEDYVMAVVDKAAE-AGGAEEQY-GFLTTPTKQPG
AQSPGREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPM
DEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYSQEYSKPAD---VTPLNGFSEGS
KTDATDGKDYNASASTISPPSSMEEDKFSRSALRDAYCSEVK---ASTTLDIKDTISA--
VSGERLSPSKSPSLSPSPPSPLEKTPLGERSVNFSLTPNEIKVSAEAEVAP-VSPEVTQE
VVEEHCASPEDKTLEVVSPSQSVTGSAGHTPYYQSPTDEKSSHLPTEVIEKPPAVPVSFE
FSD-AKDDSERASVSPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYESFLSADDKASGR
GAESPFEEKSEKQSSPDQVSPVSEMTSTSLYQDKQEGK-STDFVPIKEDFGQEKKTDDVE
ATSSQPALALDERKLG-DVSPTQIDVSQFGSFKEDTKMSISEGTVSDKSATPVDEGVAED
TYSHMEGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTF
QETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQDHRS-EQSSMSIEFGQESPEHSLAM
DFSRQSPDHPTVGAGVLHITENGPTEVDYSPSDMQDSSLSHKIPPMEEP-SYTQDNDLSE
LISVSQVEASPSTSSAHTPSQIASPLQEDTLSDVAPPRDMSLYASLTSEKVQSLEGEKLS
PKSDISPLTPRESSPLYSPTFSDSTSAVKEKTAACHTSS-SPPIDAASAEPYGFRASVLF
DTMQHHLALNRDLATPGLEK---DSGGKTPGDFSYAYQKPEKTTRSPDE-EDYDYESYEK

PF00414 // ENSGT00550000074593_0_Domain_5 (2101, 2117)

TTRTSDVGGYYYEKIERTTKSPSDSGYSYETIGK

PF00414 // ENSGT00550000074593_0_Domain_7 (2135, 2151)

TTKTPEDGDYSYEIIEKTTRTPEEGG
YSYDISEKTTSPPEVSGYSYEKTERS-RRLLDDISNGYDDSEDG

PF00414 // ENSGT00550000074593_0_Domain_12 (2205, 2220)

GHTLGDPSYSYETTEK
ITS-FPESESYSYETATK

PF00414 // ENSGT00550000074593_0_Domain_14 (2239, 2256)

TTRTPDTS-TYCYETTE

ENSGT00550000074593_0_Linker_14_15 (2256, 2257)

K

PF00414 // ENSGT00550000074593_0_Domain_15 (2257, 2289)

ITRTPQASTYSYETS---------
--------DLC---YTAE--------------KKSPSEARQDVDLCLVSSCEYKHPKTEL
SPSFINPNPLEWFASEEPTEESEKPLTQSGGAPPPPGGKQQGRQCDETPPTSVSESAPSQ
TDSDVPPETEECPSITADANIDSEDESETIPTDKTVTYKHMDPPPAPVQDRSPSPRHPDV
SMVDPEALALEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKSDGKSKPLAASPKPAGL
KESSDKVSRVASPKKKESVEKAAKPT-TTPEVK--AARGEEKDKETKNAANASASKSAKT
AT---A-GPGTTKATKSSTVPPGLPVYLDLCYIPNHSNSKNVDVEFFKRVRSSYYVVSGN
DPAAEEPSRAVLDALLEGKAQWGSNMQVTLIPTHDSEVMREWYQETHEKQQDLNIMVLAS
SSTVVMQDESFPACKIEL

------------------------------------------------------------
------------------------------------------------------------
-----MATVVVEATEPEPSGSIVSPAATTSPSLSHRFLDSKFYLLVVVGEIVTEEHLRRA
IGNIE-LGIRSWDTNLIECNLDQELKLFVSRHSARFSPEVP-----------GQKILHHR
SDVLETVVLINPSDEAVSTEVRLMITDAARHKLLVLTGQCFENTGELILQSGSFSFQNFI
EIFTDQEIGELLSTTHPANKASLTLFCPEEGDWKNSNLDRHNLQDFINIKLNSASILPEM
EGLSEFTEYLSESVEVPSPFDILEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFNML
INGGSERKSCFWKLIRHLDRVDSILLTHIGDDNLPGINSVLQRKIAELEEEQSQGSTTNS
DWXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX---X-XXX-XXXXX-LILPN-G
QEID-IPISYL-TSVSS-LIVWHPANPAEKIIRVLFPGNSTQYNILEGLEKLKHLDFLKQ
PLATQKDLTGQVATPA-LKQVKLKQRADSRESLKPAAKPLPS-KSGRKESKEETPEVTKA
NH-VEKAAKVESKDKVTVKKDK------PVKTETKPPVTEKEAPSK--EELPPAKAEGPE
K---QGTD

PF02818 // ENSGT00550000074593_0_Domain_0 (789, 814)

AKPKVTKEKTVKKETKAKPEEKKEE

ENSGT00550000074593_0_Linker_0_1 (814, 990)

KEKEKPKKEVAKKEDKTPVKKEEKPKK
EEVKKEVKKEIKKEEKKEVKKEVKKETPLKEAKKEVKKEEKKEIKKEEKEPKKEIKKLPK
DTKKSPTPVSEAKKPAALKPKVPKKEETVKKDS-VAAGQLKEKGKIKVVKKEGKAAEAVA
AA--AGTMATAAAVAAAAGIVTAGPAKEL

PF00183 // ENSGT00550000074593_0_Domain_1 (990, 1015)

EAERSLMSSPEDLTKDFEELKAEEVDVAKDI
QPQLELIEDEEKLKESEPVEAYVIQKETEVTRGPAESPDEGITTTEGEGECEQTPEELEP
VEKQGVEDTEKFEDEGAGFEESSETGDYEEKAETVKAEELEEDAEESVCVSASKHSVA--
---------EEESAKADADGHVKE-----KRESVASD-DRAED-RDEAG-EGEAEQSXXX
XXXXXXXXXXX-----XXXX-X-XXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXX--XXX----XXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXTPSEI-VSAEAEVVPA--SLEVTE
VVEEHCASLEDKTLEVVSPSQSVTGSAGHTPYYQSPTDEKSSHLPTEVIEKPAAVPVSFE
FSD-AKDESERASISPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYESFPSADDKAPER
CTESPFEGKNGKEGFPDQISPVSDMTSTGLSPDKQEGK-STDFIPIKEDFGQEKKTDDVE
AMSSQAGLALDERKLGGDVSPTQIDVGQFGSFKEDTKMSISEGTISDKSATPVDEGVAED
TYSHMEGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTF
QETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQDHRS-EQSSMSIEFGQESPEHSLAM
DFSRQSPDHPTVGASMLHITENGPTEVDYSPSDMQDSSLSHKIPPTEEP-SYTQDNDLSE
LISVSQVEASPSTSSAHTPSQIASPLQEDTLSDVVPPRDISVYASLTTEKVQSLEGEKLS
PKSDISPLTPRESSPLYSPSFSDSTSAVKESTAACHTAS-PPPMGAASAEPYGFRASMLF
DTMPHHLALKRDLTTSSLEK---DSGGKTPGDFSYAYQKPEK

PF00414 // ENSGT00550000074593_0_Domain_4 (2083, 2100)

TSRSPDE-EGYDYEAYE

ENSGT00550000074593_0_Linker_4_5 (2100, 2101)

K

PF00414 // ENSGT00550000074593_0_Domain_5 (2101, 2117)

TTRTPDVSGYYYEKTE

ENSGT00550000074593_0_Linker_5_6 (2117, 2118)

G

PF00414 // ENSGT00550000074593_0_Domain_6 (2118, 2134)

TTKSPCDRGYSYETIE

ENSGT00550000074593_0_Linker_6_7 (2134, 2135)

K

PF00414 // ENSGT00550000074593_0_Domain_7 (2135, 2151)

TTKTPEDGGYVYEITE

ENSGT00550000074593_0_Linker_7_9 (2151, 2153)

KP

PF00414 // ENSGT00550000074593_0_Domain_9 (2153, 2168)

TRSPEESG
YAYEISE

ENSGT00550000074593_0_Linker_9_10 (2168, 2169)

K

PF00414 // ENSGT00550000074593_0_Domain_10 (2169, 2185)

TIRTPEVSAYSYEKTERS-QRLLDDISNGYDDSEE

PF00414 // ENSGT00550000074593_0_Domain_12 (2204, 2220)

GGHTLGDSSYSYETTEK
TAS-FPGSESYSYETSTT

PF00414 // ENSGT00550000074593_0_Domain_14 (2239, 2256)

TTRTPVTS-AYCYETPD

ENSGT00550000074593_0_Linker_14_16 (2256, 2257)

K

PF00414 // ENSGT00550000074593_0_Domain_16 (2257, 2273)

SARTPQTSTYAFETSEQR------
--------------YTAE--------------KKSPSEARQDVDLCLVSSCEYKHPKTEL
SPSFINPNPLEWFASEEPTEESEKPLTQSGGAPPPPGGKPQGRQCDETPPTSVSESAPSQ
TDSDVPPETEECPSITADANIDSEDESETIPTDKTVTYKHMDPPPGPMQDRSPSPRHPDV
SMMDPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKGDGKSKPSAASPKPGAL
KESSDKVSRVASPKKKESVEKATKTTTTTPEVK--AARGEEKDKETKNAANASTSKSVKT
ATA----GPGNTKTSKPSAVPPGPPVYLDLCYIPNHSNSKNVDVEFFKRVRSSYYVVSGN
DPAAEEPSRAVLDALLEGKAQWGSNMQVTLIPTHDSEVMREWYQETHEKQQELNIMVLAS
SSTVVMQDESFPACKIEL

------------------------------------------------------------
------------------------------------------------------------
-----MATVVVEATEPEPSGSIANPAASTSPSLSHRFLDSKFYLLVVVGEIVTEEHLRRA
IGNIE-LGIRSWDTNLIECNLDQELKLFVSRHSARFSPDVP-----------GQKILHHR
SDVLETVVLINPSDEAVSTEVRLMITDAARHKLLVLTGQCFENTGELILQSGSFSFQNFI
EIFTDQEIGELLSTTHPANKASLTLFCPEEGDWKNSNLDRHNLQDFINIKLNSASILPEM
EGLSEFTEYLSESVEVPSPFDILEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFNML
INGGSERKSCFWKLIRHLDRVDSILLTHIGDDNLPGINSMLQRKIAELEEEQSQGSTTNS
DWMKNLISPDLGVVFLNVPENLKNPEPNIKMKRSLEEACFTLQYLSKLSMKPEPLFRSVG
NTIDPVILFQKMGVGKLEMYVLNPVKSSKEMQYFMQQW---T-GTS-KDKAE-LILPN-G
QEVD-IPITYL-TSVSS-LIVWHPANPAEKIIRVLFPGNSTQYNILEGLEKLKHLDFLKQ
PLATQKDLTGQVPTSA-VKQVKLKQRADSRESLKPATKPLAS-KSVRKESKEETPDVTKA
NH-VEKPPKVESKEKVTVKKDK------PVKIETKPPVTEKEAPSK--DEPSPVKAEVAE
K---QATDVKPKVAKEKTVKKETKVKPEEKKEE--KEKPKKEVAKKEDKTPVKKEEKPKK
EEVKKEVKKEIKKEEKKEPKKEVKKETPLKEVKKEVKKEEKKEIKKEEKEPKKEIKKLPK
DSKKSSTPLSEAKKPAALKPKVAKKEESVKKDSV-AAGKPKEKGKIKVIKKEGKTTETAA
-AAV-GAVATAAAAVAAAGIAATGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVTKDI
KPQLELIEDQEKLKETEPVEAYVI-------KGPAESPDEGITTTEGEGECEQTPEELEP
VEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEENVCVSTSKHSLI--
-------E-DEESAKAEADVHI----Q-EKRESVASGDDRAEEDMDEAVEKGEAEQSEDE
G----EEDKAEDAREEEYEPEK-IEAEDYVMAVVDKAAE-ASGAEDQY-GFLTTPAKQVG
ALSPGREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPM
DEMSTPRDVMSDETNNEETESPSQEFVNITQYESSLYSQEYKP--A---VTTLNGLSEGS
KTDATDGKDYNASASTISPPSSMEEDKFSRSALRDAYYSEVKEVKANAMLEIKDTISA--
VSDEKLSPSKSPSLSPSPPSPIEKTPLGERSVNFSLMPNEIKVSTEAEVVS-VSPEVTQE
VVEEHCASPEDKTLEVVSPSQSVTGSAGHTPYYQSPTDEKSSHLPTEVIEKPPALPVSFE
FSD-AKDESERASISPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYESFLSADGKASGR
CTESPFEEKNGKQGFPDQISPVSEMTSTGLYQDKQEGK-STDFIPIKEDFGQEKKTDDAE
AISSQPALALDERKLGGDVSPTQIDVSQFGSFKEDTKMSISEGTVSDKSATPVDEGVAED
TYSHMEGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTF
QETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQEHRS-EQSSMSIEFGQESPEHSLAM
DFSRQSPDHPAVGASMLHITENGPTEVDYSPSDMQDSSLSHKIPPTEEP-SYTQDNDLSE
LISVSQVEASPSTSSAHTPSQIASPLQEDTLSDVAPPRDISLYASLTSEKVQSLEGEKLS
PKSDISPLTPRESSPLYSPSFSDSTSAVKENIAACHPSS-SPPIDAASAESYGFRASMLF
DTMQHHLALNRDLTTSGMEK---DSGGKTPGDFSYAYQTHEKTTGSPDE-EDYDYASYEK

PF00414 // ENSGT00550000074593_0_Domain_5 (2101, 2117)

TTRPPDLGGYYYEKTE

ENSGT00550000074593_0_Linker_5_6 (2117, 2118)

R

PF00414 // ENSGT00550000074593_0_Domain_6 (2118, 2132)

TTKSPGDSDYSYETIVKPTKTPEHGGYAYEITEK

PF00414 // ENSGT00550000074593_0_Domain_9 (2152, 2168)

TTRTPEEGG
YSYEISE

ENSGT00550000074593_0_Linker_9_10 (2168, 2169)

K

PF00414 // ENSGT00550000074593_0_Domain_10 (2169, 2185)

TTRTPDVSGYSYEKTERS-TRLLDDISNGYDVSEDR

PF00414 // ENSGT00550000074593_0_Domain_12 (2205, 2220)

GHTLGDSSYSYETTEK
ITS-FPESDSYSYETSTK

PF00414 // ENSGT00550000074593_0_Domain_14 (2239, 2256)

TTRSPDTS-TYCYETTE

ENSGT00550000074593_0_Linker_14_15 (2256, 2257)

K

PF00414 // ENSGT00550000074593_0_Domain_15 (2257, 2290)

ITRTPQASTYSYETS---------
--------DRC---YAAE--------------KKSPSEARQDVDLCLVSSCEYKHPKTEL
SPSFINPNPLEWFASEEPTEESEKPLTQSGGAPPPPGGKQQGRQCDETPPTSVSESAPSQ
TDSDVPPETEECPSITADANIDSEDESETIPTDKTVTYKHMDPPPAPMQDRSPSPRHPDV
SMVDPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKSDGKSKPSAASPKPAGL
KESSDKVSRVASPKKKESVEKATKTT-TTPEVK--AVRGEEKDKETKNAANASTSKSVKT
ATA----GPGTTKTIKSSAVPPGLPVYLDLCYIPNHSNSKNVDVEFFKRVRSSYYVVSGN
DPAAEEPSRAVLDALLEGKAQWGSNMQVTLIPTHDSEVMREWYQETHEKQQDLNIMVLAS
SSTVVMQDESFPACKIEL

MTSASGQRLEKRRQPPREDVPGGPFLLLFLLLPGS-------LPS--LHIKAAPPPRPLS
LPAPLRRALSAALGEGGGGGGARRQRRGDAGGGAETAPSEIILSPAAEERSGRSETLRPG
TAAGRMATVVVEATEPEPSGSIANPAASTSPSLSHRFLDSKFYLLVVVGEIVTEEHLRRA
IGNIE-LGIRSWDTNLIECNLDQELKLFVSRHSARFSPEVP-----------GQKILHHR
SDVLETVVLINPSDEAVSTEVRLMITDAARHKLLVLTGQCFENTGELILQSGSFSFQNFI
EIFTDQEIGELLSTTHPANKASLTLFCPEEGDWKNSNLDRHNLQDFINIKLNSASILPEM
EGLSEFTEYLSESVEVPSPFDILEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFNML
INGGSERKSCFWKLIRHLDRVDSILLTHIGDDNLPGINSMLQRKIAELEEEQSQGSTTNS
DWMKNLISPDLGVVFLNVPENLKNPEPNIKMKRSIEEACFTLQYLNKLSMRPEPLFRSVG
NTIDPVILFQKMGVGKLEMYVLNPVKSSKEMQYFMQQW---T-GTN-KDKAE-LILPN-G
QEVD-LPISYL-TSVSS-LIVWHPANPAEKIIRVLFPGNSTQYNILEGLEKLKHLDFLKQ
PLATQKDLTGQVPTPV-VKQTKLKQRADSRESLKPATKPLPS-KSVRKESKEETPEVAKV
NH-VEKPPKVESKEKVTVKKDK------PVKTETKPSVTEKEVPSK--EEPSPVKAEVAE
K---QATDVKPKAAKEKTVKKETKAKPEDKKEE--KEKPKKEVAKKEDKTPIKKEEKPKK
EEVKKEVKKEIKKEEKKEPKKEVKKETPLKEAKKEVKKEEKKEVKKEEKEPKKEIKKLPK
DAKKSSTPLSEAKKPAALKPKVPKKEEPVKKDSV-AAGKPKEKGKIKVIKKEGKATEAVA
A-AV-GTGAATAAVVAAAGIAATGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVTKDI
KPQLELIEDEEKLKETEPVEAYVIQKETEVTKGPAESPDEGITTTEGEGECEQTPEELEP
VEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEEHICVSASKHSPT--
-------E-YEESAKAEADAYI----R-EKRESVASGDDRAEEDMDEAIEKGEAEQSEEE
A--D-EEDKAEDAREEEYEPEK-MEAEDYVMAVVDKAAE-AGGAEEQY-GFLTTPTKQPG
AQSPGREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPM
DEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYSQEYSKPAD---VTPLNGFSEGS
KTDATDGKDYNASASTISPPSSMEEDKFSRSALRDAYCSEVK---ASTTLDIKDTISA--
VSGGKLSPSKSPSLSPSPPSPLEKTPLGERSVNFSLTPNEIKVSAEAEVAP-VSPEVTQE
VVEEHCASPEDKTLEVVSPSQSVTGSAGHTPYYQSPTDEKSSHLPTEVIEKPPAVPVSFE
FSD-AKDDSERASVSPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYESFLSADDKASGR
GAESPFEEKSEKQSSPDQVSPVSEMTSTSLYQDKQEGK-STDFVPIKEDFGQEKKTDDVE
ATSSQPALALDERKLG-DVSPTQIDVSQFGSFKEDTKMSISEGTVSDKSATPVDEGVAED
TYSHMEGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTF
QETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQDHRS-EQSSMSIEFGQESPEHSLAM
DFSRQSPDHPTVGAGVLHITENGPTEVDYSPSDMQDSSLSHKIPPMEEP-SYTQDNDLSE
LISVSQVEASPSTSSAHTPSQIASPLQEDTLSDVAPPRDMSLYASLTSEKVQSLEGEKLS
PKSDISPLTPRESSPLYSPTFSDSTSAVKEKTAACHTSS-SPPIDAASAEPYGFRASVLF
DTMQHHLALNRDLATPGLEK---DSGGKTPGDFSYAYQKPEKTTRSPDE-EDYDYESYEK

PF00414 // ENSGT00550000074593_0_Domain_5 (2101, 2117)

TTRTSDVGGYYYEKIERTTKSPSDSGYSYETIGK

PF00414 // ENSGT00550000074593_0_Domain_7 (2135, 2151)

TTKTPEDGDYSYEIIEKTTRTPEEGG
YSYDISEKTTSPPEVSGYSYEKTERS-RRLLDDISNGYDDSEDG

PF00414 // ENSGT00550000074593_0_Domain_12 (2205, 2220)

GHTLGDPSYSYETTEK
ITS-FPESESYSYETATK

PF00414 // ENSGT00550000074593_0_Domain_14 (2239, 2256)

TTRTPDTS-TYCYETTE

ENSGT00550000074593_0_Linker_14_15 (2256, 2257)

K

PF00414 // ENSGT00550000074593_0_Domain_15 (2257, 2289)

IARTPQASTYSYETS---------
--------DLC---YTAE--------------KKSPSEARQDVDLCLVSSCEYKHPKTEL
SPSFINPNPLEWFASEEPTEESEKPLTQSGGAPPPPGGKQQGRQCDETPPTSVSESAPSQ
TDSDVPPETEECPSITADANIDSEDESETIPTDKTVTYKHIDPPPAPVQDRSPSPRHPDV
SMVDPEALALEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKSDGKSKPLAASPKPAGL
KESSDKVSRVASPKKKESVEKAAKPT-TTPEVK--AARGEEKDKETKNAANASASKSAKT
AT---A-GPGTTKATKSSTVPPGLPVYLDLCYIPNHSNSKNVDVEFFKRVRSSYYVVSGN
DPAAEEPSRAVLDALLEGKAQWGSNMQVTLIPTHDSEVMREWYQETHEKQQDLNIMVLAS
SSTVVMQDESFPACKIEL

------------------------------------------------------------
------------------------------------------------------------
-----MATVVVEA-ESEPSCSIPN-AASTSPSLSHRFLDSKFYLLVVIGEIVXXXXXXXX
XXXXX-XXIRSWDTNLIECNLDQELKLFVSRHSARFSPDVR-----------XXXXXXXX
XXXXXXXXXXXXXXXXXXXXVRLMITDAARHKLLVLTGQCFENTGELILQSGSFSFQNFI
EIFTDQEIGELLSTTHPANKASLTLFCPEEGDWKNSNLDRHNLQDFINIKLNSASILPEM
EGLSEFTEYLSESVEVPSPFDILEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFNML
INGGSERKSCFWKLIRHLDRVDSILLTHIGDDNLPGINSMLQRKIAELEEEQSQGSTTNS
DWMKNLISPDLGVVFLNVPENLKNPDPNIKMKRSIEEACFTLQYLNKLSMKPEPLSRSVG
NTIDPVILFQKMGVGKLEMYVLNPVKSSKEMQYFMNQW---T-GTN-KDKAE-LILPN-G
QEVD-IPISYL-TSVSS-LIVWHPANPAEKIIRVLFPGNSTQYNILDGLEKLKHLDFLKQ
PMVTQKDLSGQVASPA-VKQVKLKQRTDSRESLKPVAKTLSS-KPVRKESKEETPETTKI
NH-VEKAPKIESKEKVIVKKEK------PIKTEAKPSVPEKEISIK--EDQSVVKAEVAE
K---QATDVKPKVTKDKIVKKEVKTKSEDKKEE--KEKPKKEVTKKEEKTPLKKEEKPKK
EDVKKEV----KKEEKKELKKEIKKETPLKEIKKEVKKEEKKEIKKEEKEIKKDIKKLPK
DTKKLSAPVSEAKKP-ILKPKVQKKEEPIKKETT-AAGKPKEKGKIKVVKKESKVSETTA
-ATI-GTAATAATVAAATGIATTGPGKEL

PF00183 // ENSGT00550000074593_0_Domain_1 (990, 1015)

EAERSLMSSPEDLTKDFEELKAEEV

ENSGT00550000074593_0_Linker_1_2 (1015, 1492)

DVLKET
KPQLELIEDEEKLTETEQVEAYVIQKETEVIKGPAESPDEGITTTEVEGECEQTPEELEP
AEKHREDDNEKFEDEGTGFEESSEAGDYEEKAETEEAEEPDYEGDENVPLSSAKHGTT--
-------E-AEEDMKVEADGHG----K-EKRESLAGGDERAEEDMDEIIEKAEAEETEEE
L--D-EEEKTEDARDDDYEMEKHLAEEDYVMAVVDKAAE-AADAEDKY-GLLLTPSKQSG
AQSPAREPASSIHDETLPGGSESEATVSDEENREDQPEEFTATSGYTQSTIEISSEPTPM
DEMSTPRDVMSDETNNEESESPSQEFVNITKYESSLYSQEYTKPKL---PDAFNGLSDGS
KTDATDGRDYNASASTISPPSSMEEDRFSRSILQEAYHSSDRDMKTTAMLDIKDDSST--
VSDEKISPAKSPSLSPAPPSPVAKTPIGERSVNFSLTPNEIKVSAEAEVIP

PF02818 // ENSGT00550000074593_0_Domain_2 (1492, 1516)

-KSPELPQE
VLEEHCASPEDKTLEVVSPSQSVAGSAGHTPYYQSPTDEKSSHLPSDVTEKAPSVPVSFE
FDD-AKDENGKTSVSPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYETFLSTDVKTSGR
HIESPFEEKLGKQESPSEISPVSEMTSTGLFQEQHDEK-SAEFIPIKEDLGQEKKMEDFE
AVGSQPGLSLDERKLAGDVSPTQIDISQFGSFKEDTKMSISEGTVSDKSATPVDEGVAED
TYSHIEGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTF
QETEMSPSK-ECPRPMSISPPDFSPKTAKS-TPVQEHK--SQSSMSIEFDQESPEQSLM-
DFXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXX---XXERKKPDDYSYTYQKTEK

PF00414 // ENSGT00550000074593_0_Domain_4 (2083, 2100)

TTRSPDE-EDYVYETCE

ENSGT00550000074593_0_Linker_4_5 (2100, 2101)

K

PF00414 // ENSGT00550000074593_0_Domain_5 (2101, 2117)

TSRSSELGSYSYEKTE

ENSGT00550000074593_0_Linker_5_6 (2117, 2118)

R

PF00414 // ENSGT00550000074593_0_Domain_6 (2118, 2134)

TTRSPHDSGYSYETIEKTFRVPEGCGFAYEITEK

PF00414 // ENSGT00550000074593_0_Domain_9 (2152, 2168)

TKRTPEEGG
YSYETSE

ENSGT00550000074593_0_Linker_9_10 (2168, 2169)

K

PF00414 // ENSGT00550000074593_0_Domain_10 (2169, 2185)

IMRTPELGGYTHEKTERA-SRLLDDISNGYDDSED

PF00414 // ENSGT00550000074593_0_Domain_12 (2204, 2220)

GSQTPGDSTYSYETTEK
ISS-FPDSESYSYETSKRTSEMPESP-TCCYETTEK

PF00414 // ENSGT00550000074593_0_Domain_15 (2257, 2290)

ITRTPQASTYSYETS---------
--------D

ENSGT00550000074593_0_Linker_15_17 (2290, 2515)

HC---FPAE--------------KKSPTQARQDVDLCLVSSCEYKHPKTEL
SPSFINPNPLEWFASEEQAQEYEKPLTQAGGGPPPPGGKQQGRQCDETPPTSVSESAPSQ
TDSDVPPETEECPSITADANIDSEDESETIPTDKTVTYKHIDPPPVPMQDRSPSPRHPDV
SMVDPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKADGKSKQSAAS

PF02818 // ENSGT00550000074593_0_Domain_17 (2515, 2538)

PKPAGL
KESLEKVSRTTSPKKKESVEKTTKTS-ATPEVK--ASRVEEKDKEAKNATNTSTSKSAKT
AAA----GSGPTKTAKSSAVPPGPPVYLDLVYIPNHSNSKNVDVEFFKRVRSSYYVVSGN
DPAAEEPSRAVLDSLLEGKAQWGSNMQ---------------------------------
------------------

------------------------------------------------------------
------------------------------------------------------------
-----MATVVVEATEPEPSGSIANPAASTSPSLSHRFLDSKFYLLVVVGEIVTEEHLRRA
IGNIE-LGIRSWDTNLIECNLDQELKLFVSRHSARFSPEVP-----------GQKILHHR
SDVLETVVLINPSDEAVSTEVRLMITDAARHKLLVLTGQCFENTGELILQSGSFSFQNFI
EIFTDQEIGELLSTTHPANKASLTLFCPEEGDWKNSNLDRHNLQDFINIKLNSASILPEM
EGLSEFTEYLSESVEVPSPFDILEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFNML
INGGSERKSCFWKLIRHLDRVDSILLTHIGDDNLPGINSMLQRKIAELEEEQSQGSTTNS
DWMKNLISPDLGVVFLNVPENLKNPEPNIKMKRSIEEACFTLQYLNKLSMKPEPLFRSVG
NTIDPVILFQKMGVGKLEMYVLNPVKSSKEMQYFMQQW---T-GTN-KDKAE-LILPN-G
QEVD-LPISYL-TSVSS-LIVWHPANPVEKIIRVLFPGNSTQYNILEGLEKLKHLDFLKQ
PLATQKDLTGQVPTPV-VKQTKLKQRADSRESLKPATKPLPS-KSVRKESKEETPEVTKV
NQ-VEKPPKVESKEKVTVKKDK------PVKTETKPSVTEKEVPSK--EEPSPVKAEVAE
K---QATDVKPKAAKEKTVKKETKAKPEDKKEE--KEKPKKEVAKKEDKTPIKKEEKTKK
EEVKKEVKKEIKKEEKKEPKKEVKKETPLKEAKKEVKKEEKKEVKKEEKEPKKEIKKLPK
DAKKSSTPLSEAKKPAALKPKVPKKEEPVKKDSV-AAGKPKEKGKIKVVKKEGKATEAVA
A-AV-GTGAATAAVVAAAGIVATGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVTKDI
KPQLELIEDEEKLKETEPVEAYVIQKETEVTKGPAESPDEGITTTEGEGECEQTPEELEP
VEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEEHICVSASKHSPT--
-------ED-EESAKAEADAYI----R-EKRESVASGDDRAEEDMDEAIEKGEAEQSEEE
A--D-EEDKAEDAREEEYEPEK-MEAEDYVMAVVDKAAE-AGGAEEQY-GFLTTPTKQPG
AQSPGREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPM
DEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYSQEYSKPAD---VTPLNGFSEGS
KTDATDGKDYNASASTISPPSSMEEDKFSRSALRDAYCSEVKA---STTLDIKDTISA--
VSGEKLSPSKSPSLSPSPPSPLEKTPLGERSVNFSLTPNEIKVSAEAEVAP-VSPEVTQE
VVEEHCASPEDKTLEVVSPSQSVTGSAGHTPYYQSPTDEKSSHLPTEVIEKPPAVPVSFE
FSD-AKDESERASVSPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYESFLSADDKASGR
GAESPFEEKSEKQGSPDQVSPVSEMTSTSLYQDKQEGK-STDFVPIKEDFGQEKKTDDVE
ATSSQPALALDERKLG-DVSPTQIDVSQFGSFKEDTKMSISEGTVSDKSATPVDEGVAED
TYSHMEGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTF
QETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQDHRS-EQSSMSIEFGQESPEHSLAM
DFSRQSPDHPTVGAGVLHITENGPTEVDYSPSDMQDSSLSHKIPPMEEP-SYTQDNDLSE
LISVSQVEASPSTSSAHTPSQIASPLQEDTLSDVAPPRDMSLYASLTSEKVQSLEGEKLS
PKSDISPLTPRESSPLYSPAFSDSTSAVKDKTAACHTSS-SPPIDAASAEPYGFRASVLF
DTMQHHLALNRDLATPGLEK---DSGGKTPGDFCYAYQKPEKTTRSPDE-EDYDYESYEK

PF00414 // ENSGT00550000074593_0_Domain_5 (2101, 2117)

TTRTSDVGGYYYEKIERTTKSPSDSGYSYETIGK

PF00414 // ENSGT00550000074593_0_Domain_7 (2135, 2151)

TTKTPEDGDYSYEIIEKTTRTPEEGG
YSYDISEKTTSPPEVSGYSYEKTERS-RRLLDDISNGYDDSEDG

PF00414 // ENSGT00550000074593_0_Domain_12 (2205, 2220)

GHTLGDPSYSYETTEK
ITG-FPESESYSYETAKK

PF00414 // ENSGT00550000074593_0_Domain_14 (2239, 2256)

TTLTPDTS-TYCYETTE

ENSGT00550000074593_0_Linker_14_15 (2256, 2257)

K

PF00414 // ENSGT00550000074593_0_Domain_15 (2257, 2289)

ITRTPQASTYSYETS---------
--------DLC---YTAE--------------KKSPSEARQDVDLCLVSSCEYKHPKTEL
SPSFINPNPLEWFASEEPTEESEKPLTQSGGAPPPPGGKQQGRQCDETPPTSVSESAPSQ
TDSDVPPETEECPSITADANIDSEDESETIPTDKTVTYKHMDPPPAPVQDRSPSPRHPDV
SMVDPEALAIEQNLGKALKKDLKEKTKTKKPGTKPSHLHLSKRVMGSLSPWQLHQNQGA-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------

------------------------------------------------------------
------------------------------------------------------------
-----MATVVVEATEPEPSASIANPAASTSPSLSHRFLDSKFYLLVVVGEIVTEEHLRRA
IGNIE-LGIRSWDTNLIECNLDQELKLFVSRHSARFSPEVP-----------GQKILHHR
SDILETVVLINPSDEAVSTEVRLMITDAARHKLLVLTGQCFENTGELILQSGSFSFQNFI
EIFTDQEIGELLSTTHPANKASLTLFCPEEGDWKNSNLDRHNLQDFINIKLNSASILPEM
EGLSEFTEYLSESVEVPSPFDILEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFNML
INGGSERKSCFWKLIRHLDRVDSILLTHIGDDNLPGINSMLQRKIAELEEEQSQGSTTNS
DWMKNLISPDLGVVFLNVPENLKNPEPNIKMKRSIEEACFTLQYLNKLSMKPEPLFRSVG
NTIDPVILFQKMGVGKLEMYVLNPVKSSKEMQYFMQQW---T-GTN-KDKAE-LILPN-G
QEVD-LPISYL-TSVSS-LIVWHPANPAEKIIRVLFPGNSTQYNILEGLEKLKHLDFLKQ
PLATQKDLTGQVTTPV-VKQTKLKQRADSRESLKPATKPLPS-KTVRKESKEETPEVTKV
NQ-VEKPPKVESKEKVTVKKDK------PVKTETKPSVTEKEVPSK--EEPSPVKAEVAE
K---QATDVKPKAAKEKTVKKETKVKPEDKKEE--KEKPKKEVAKKEDKTPIKKEEKPKK
EEVKKEVKKEIKKEEKKEPKKEVKKDTPPKEAKKEVKKEEKKDVKKEEKEPKKEIKKLPK
DSKKSSTPLSEAKKPAALKPKVPKKEESVKKDSV-AAGKPKEKGKIKVIKKEGKAAEAVA
A-AV-ATGASTA--AAAAGIAATGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVTKDI
KPQLELIEDEEKLKETEPVEAYVIQKETEVTKGSAESPDEGITTTEGEGECEQTPEELEP
VEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEEHVCVSTSKHSPT--
-------ED-EESAKAEADAYI----R-EKRESVASGDDRAEEDMDEAIEKGEAEQSEEE
A--D-EEDKAEDAREEEYEPEK-IEAEDYVMAVVDKAAE-AGGAEEQY-GFLTTPTKQPG
AQSPGREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPM
DEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYSQEYSKPAA---VTPLNGFSEGS
KTDATDGKDYNASASTISPPSSMEEDKFSRSALRDAYCSEVKA--ASPTLDIKDAVSA--
VSGEKLSPSKSPSLSPSPPSPIEKTPLGERSVNFSLTPNEIKVSAEAEVAP-VSPEVTHE
VVEEHCASPEDKTLEVVSPSQSVTGSAGHTPYYQSPTEEKSSHLPTEVIEKPPAVPVSFE
FSD-AKDENERASVSPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYESFLSADGKASGR
GAESPFEEKSGKQGSPDQISPVSEMTSTSLYQDKQEGK-STDFVPIKEDFGQEKKIYDGE
ATSAQPAMALDERKLG-DVSPTQIDVSQFGSLKEDTKMSISEGTVSDKSATPVDEGVAED
TYSHMEGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTF
QETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQDHRS-EQSSMSIEFGQESPEHSLAM
DFSRQSPDHPTVGAGVLHITENGPTEVDYSP-DMQDSSLSHKILPMEEP-SYTQDNDLSE
LISVSQVEASPSTSSAHTPSQIASPLQEDTLSDVAPPRDMSLYASLTSEKVQSLEGEKLS
PKSDISPLTPRESSPLYSPTFSDSTSAVKEKTAAGHTSS-SPPIDAASAEPYGFRASVLF
DTMQHHLALNRDLATPGME----DSGGKTPGDFSYAYQKPEKTTRSPDE-EDYDYESYEK

PF00414 // ENSGT00550000074593_0_Domain_5 (2101, 2117)

TTRTSDVGGYYYEKTERSTKSPSDSGYSYETIGK

PF00414 // ENSGT00550000074593_0_Domain_7 (2135, 2151)

TTKTPEDGDYSYEIIEKTTRTSEEGG
YSYEISEKTTSPPEMSGYSYEKTERS-RRLLDDISNGYDDSEDG

PF00414 // ENSGT00550000074593_0_Domain_12 (2205, 2220)

GHTLGDPSYSYETTEK
ITS-YPESESYSYETSTK

PF00414 // ENSGT00550000074593_0_Domain_14 (2239, 2256)

TTRTPDTS-TYCYETTE

ENSGT00550000074593_0_Linker_14_15 (2256, 2257)

K

PF00414 // ENSGT00550000074593_0_Domain_15 (2257, 2289)

ITRTPQASTYSYETS---------
--------DLC---YSVE--------------KKSPSEARQDVDLCLVSSCEYKHPKTEL
SPSFINPNPLEWFASEEPTEESEKPLTQSGGAPPPPGGKQQGRQCDETPPTSVSESAPSQ
TDSDVPPETEECPSITADANIDSEDESETIPTDKTVTYKHMDPPPAPVQDRSPSPRHPDV
SMVDPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKSDGKSKPLAASPKPGGL
KESSDKVSRVASPKKKETVEKAAKPT-TTPEVK--AARGEEKDKETKNAANVSASKSAKT
AT---A-GPGTTKTTKSSAVPPGLPVYLDLCYIPNHSNSKNVDVEFFKRVRSSYYVVSGN
DPAAEEPSRAVLDALLEGKAQWGSNMQVTLIPTHDSEVMREWYQETHEKQQDLNIMVLAS
SSTVVMQDESFPACKIEL