ENSGT00550000074488_0 : Linker Region Query Results

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---------------------------------------MAGTKN--KTRAQAKTEKK-A
AIQAKAGAEREATGV------VRPV---------------------AKTRAKAKAKTGSK
-----TDAV---------------------------------------------------
------AEMKAV-------------SKNKVVAETKEGALSEPKTLGKAM-----------
-----GDF----------------------------TPKAGNESTSSTCKNEAGTDAWFW
AGEE------------------------ATINSWFWNGEEAGN-SFST------------
---------KNDKP--------EIGAQVCA----E-------------------------
------------ELEPAAGADCKPRSGAEE------------------------------
EEEENVIGNWFWEGDDTSFDP-NPKPVSRIVKPQP---VYEINEKNRPKDWSEVTIWPNA
PAVTP---AVLGFRSQAPSEASPPS----YIVLASAEENACSLPVA------TACRPSRN
TRSCSQPIPECRFDSDPCI--------------------QTIDEIRRQIRIREVNGIKPF
ACPCKM------ECYMDSEEFEKLVSLLKSTTDPLIHKIARIAMGVHNVHPFAQ------
----------EFINEVGVVTLIESLLSFPSPEM-------RKKTVITL-NP-PSGDERQR
KIELHVKHMCKETMSFPLNSPGQQSGLKILGQLTTDFVHHYIVANYFSEL-FHLLSSGNC
K-TR-NLVLKLLLNMSENPTAARDMINMK---ALAALKLIFNQKEAK----------ANL
VSGVAIFINIKEHIRKGSIVVVD----------HLSY--NTLM-AIFREVKEIIETM---
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-------------------------------------------

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---------------------------------MGRTREAGCVAAG----------VVIG
AGACYCVYKLT--WGRDE-NEKILD----EDEESTDT--S--------------------
----------------------------ETGVETV------KGAKANVGAGSGVKL-HGD
------------SKVK--------PEVSLGL------------EN--------CPGVKEK
VHS----------------G--------SHNGGGLE---AKA------------------
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-------KALFNM-----------------------------------------------
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------L-KE--------------------------------------------------
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------------------QASAKAGKGVRVGII---------------------------
-----------SG---------------------------------NRTLAPSLPCPGGR
GG---------GCHPTRSGSR-------------A--------------------GGRAS
GKSKGKARSKSTRAPA-T---------------------------TW----PVRRGKFNF
PYKID--------DILSAPDLQKVLNILERTNDPFIQEVALVTLGNNAAYSFNQ------
----------NAIRELGGVPIIAKLIKTKDPII------RE-KTYNALNNL-SVNAENQG
KIKTYISQVCDDTMVCRLDSAVQMAGLRLLTNMTVTNHYQHLLSYSFPDF-FALLFLGNH
F-TK-IQIMKLIINFTENPAMTRELVSCK---VPSELISLFNKEWDR----------EIL
LNILTLFENINDNIKSEGLASS---------RKEFSR--SSLFF-LFKESGVCVKKIKAL
A-NHNDLVVKVKVLKVLTKL----------------------------------------
-------------------------------------------

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--------------DTDLRHV--EQD--RYIELYNTL---AMTEN--QTRVWAKTGKG-A
DVRA--EAEREATGI------VKA-------------------------------KARLE
-----IDTV---------------------------------------------------
------EVK-AG-------------SKGKVAAKMEERSVEKPNTLGCVV-----------
-----GDF----------------------------VPKAGGEATKSTHKDGTGIDAWFW
VGEE------------------------AGIGPWFWNGEKAGH-QFSA------------
---------KNVDE-------TDTGPSINA----EEL-----------------------
------------GIESVTGASCKPRPGAEE------------------------------
KEKEKVIGNWFWDGDDTSFDP-NPKPVYRIIKPQV---ACETDEKNKLKEWCEGTAWHNT
SAEIS---AFLAFASQVLQRMRHVS----YNVLVSGKKNTGSLSLM--------TSLSEG
TCICLEFIDAYPFESRTCT--------------------QTIVKIREQIRIRELSGIKRF
GCPCKM------ECCLGSEGFEKLVSLLKSDTDPLIHKIAQIAMGIINVHPLAP------
----------QCINEMGVLTFIESLLDFQFPNV-------ARKSEITL-NP-ISAEEKQR
MIQLHVLHMCKDTVTFPLNSPGQRSGLKELGQLTTNFDYHYIISTYFAEL-CHVLSLGNS
K-TR-NLVLQIILNMSENM-TARDMTDFD---YLSVLKLIFSQTEAK----------ANL
VTAVAILLNIKEHIRKASIIVVN----------PQCY--DELK-AMFCEVETIIERL---
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-------------------------------------------

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--SYD--------DVLNAEQLQKLLYLLELTEDPAIIERALVTLGNNAAFSANQ------
----------VIIRELGGIPIVGSKIKDPNHSI------KE-KALNALSNL-SVNVENQI
KIKVYVNQVCEDVLSGPLNSPVQLAGLRLLTNMTVTNDHQHMFTNYITDL-FQVLLAGNG
T-TK-VQVLKLLLNLSENPAMTEGLLGAQ---VDSSFLSLYDGHVAK----------EIL
LRALTLFQNINNCLKKEGHLTV---------QPTFTQ--GSLFFLLYGE--ECAQKMRAL
V-NHHDADVKEKLLNLNSKYQTSS--------F-PQLEL---------------------
-------------------------------------------

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---------------------------------MGGARDVGWVAAG----------LVLG
AGACYCIYRLT--RGPRR-GGR-----------RLRP--SR-------------------
------------------------------------------SAE---------------
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DGSYD--------DILNVEQLAKLLYLLESTDDPIITEKALVTLGNNAAFSTNQ------
----------AIIRELGGIPIVGNKINSLNQSI------KE-KALNALNNL-SVNVENQT
KIKIYVPQVCEDVFADPLNSAVQLAGLRLLTNMTVTNDYQHLLSSSVASL-FHLLLLGNG
S-TK-VQVLKLLLNLSENPAMTEGLLSVQ---VDSSFLSLYDGQVAN----------EIL
LRALTLFQNINNCLKVEGRLAN---------QIPFAK--GSLFFLLYGE--ECAQKMRAL
A-CHHDVDVKEKALAIKPKF----------------------------------------
-------------------------------------------

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-------MTGAEIESGAQVKPEKKPGEEVV--------G-----------GAEIENDVPL
VVRPKV--------------------------RTQAQIMPGARPKDKSKVIPGASTKV--
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------------------------------------------------E------TSAVG
GARPKS--KAKAIPVSRFKEEA--------------Q--------------MWAQPRFG-
-----PERLSKTERNSQTNIIASPLVSTDS--VLVAKTKYLSEDRELVNTDTESFPGRKA
HYQAGFQPFFRSK-EETN------------------------------------------
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---MGSWCCPRPTSK-QEVSPNSDFKWVDKSSVSSLFWSGDEVTAKFHPGNRVKD-SARS
RHMANQE-----A--NTMSRSQTNQELYISS-SSGSE-----------------------
-DESVKTPWFWARDKTNTWS--GPREDP-NSRSRFRAKKEVYV------------ESSSG
SEHEDHLESWFGAGEEAKFRCKMRAGKETNNRARHRAKREACIDFMPGSI------DVIK
RESCFWPEENA---------NTF-----SRPMIKKEARARAMAK----------------
EE----AKTKARARAKQEARS-----EEESLIGTWFWATDESSMADEASIESSLQVEDES
IIGSWFWTEEEASMGTGASSKS-RPRTDGEPIGDSLFGTG-EKTSMKTGAEATSECILAA
DDE-QVIIGSWFWAGEE-VN---------------------------------QEAEEET
IFGSWFWVTDAAS-VESGFGVSCE-------------------------------SRSR-
-SEEEEVIGPWFWSGEQVDIEAGIGEE----------ARPGAEEETIFGSWFWAENHTYM
DCR------AEASCGTMQGAE----EEGPIIGSWFWTRVEACVEGDVNSKSSLEDKEE-A
MI-PCFGAKEKVSMKHGTDVRCRFMAGAEETNNRSCFWAEKEPCMYPTCGGIWKTRPEEE
-----EDIVNSWFWSRKYTKPEAIIG------------------------SWLWATEESN
I-DGTGEEAKLLTEEETMINSWFWKD--EAISEATDREESRPEAEEGDIIGSWFWAGEED
RLEPAAEVREEDRLVAEKE-GIVGSWFGAREETIRREAGSCSKSSPKAEEEEVIIGSWFW
EEEASLEAVAGVGFESKPGTEKE----EITVGSWFWPEEETSIEAGSQAVEEMESETEEE
TIFGSWFWAGKE-----VSEEAGPCCVSKSEDD-EEMI----------------------
-IESWFWSGDKATKETGTVATCESKPENEEGAIVGSWFEAEDEVDNRTDNGSNCESRTLA
DEDEAIVGSWFWAGDEAHFGS-NPSPVFRAICRSTCSVEQEPDPSRRPQSWEEVTVQFKP
-GPW----GRVGFPSISPFRFPKEA-ASLFCEMFGGKPRNVVLSPEG----E--DQESLL
QPDQ--PDPEFPFQYDPSY--------------------RSVQEIREHLRAKESAEPESW
SCSCIQ-----CELKIGSEEFEELLLLMEKIRDPFIHEISKIAMGIRSASQFTR------
----------DFIRDSGVVSLIETLLNYPSSRV------RT-RFLENMIRM-APPYPNLN
MIQTYICKVCEETLAYSLDSPEQLSGIRMIRHLTITTDYHTLVANYMSGF-LSLLATGNT
K-TR-FHILKMLLNLSENLLMTKELLSAE---AVSEFMGLFNREETN----------DNI
QIVLAIFENIGNNIKKET-VFT---------DDDFNL--EPLI-SAFHKVEKFAKELQGK
TDNQNDPEGDQEN-----------------------------------------------
-------------------------------------------

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--------------------------------------------MGRIQEVGWVTAGLVI
WAGTCYYIYKLTKGRAQSVRTHARNESTV-KMETVVE----VQNQTLAIGEAE----IET
KSQAEIEAETGAGGGPGAEVETKATAIARHKANSQ----AKAMIGAEAETQSE-------
SKVVAGSLVMTEAVTLTEAK--AKAREVAMKEAVTQTDAEAGKIVKKEAVTQTK-AKAWA
SVAKTEAKREAMTQTKAETHILAEKEAEMHRVMVPQSETLAVPGE----VAKMGATNKTG
IVDETKTRALEETVSVAKTQSEARPGSTVDARGNPNGMSREVAGVDMKSCAQSQAVAKIQ
GDDMPGARIEDMGNWK---------------------------TMSREESGADTRASSQP
QIVAKTQIEAIPGAKVDAGGNTSAMCKVGAGAD---------TVAKKQAEVTSGSR-ADG
RGNTNVISKAITGADMRAAAQPQAIAGPHAEAMSDAKVKERGNPNAVTKAGTRTNLRANS
QVEALPNARDKSRGNPSVMAKMGDGADMLSCT-QPQLVAIVQANTLSDGRIKVKGNVNSM
PKEGSGMDMKAQ--CMAQSQGEALPNARG-------------------------------
-----------KGNLNAISKAGTKADQKAYGQSLVVANPQGEGLPAAKNKAKGNPHAVPK
MGAGEGTTDSAQLQAV---------------------------------------VSFQG
DALLGTKTKVKDNPNAVLKAEVGAGAMGTAQLQIVASSKGEALFDSKNKAKVNSNAVSKA
GAGTDTMGSAQPQIVANSQSEVLPGAKNKVRGNPTTMPSSGAAPYI--------------
--------------------------MDSAQPQAVATSQDEVLPSAKNKVKANLHALSKA
EAGMGAT-----------------------------------------------------
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--------------------------------------GSVQSQAVANSQGETLPGAKNK
VRGNWNTVSKAGAGMDTTGSAQPQAVANSQGEVLPGAKNKVKGNPNVVSKAGAREDKTGS
VQP---------------------------------------------QVVANSQHETFS
GARNKVKGNSNAISKAEAGSGIMGSVQ--VVASSHGKVLPGAKNKVRGN--SSAVPKAEA
GADTVGSGQPQAVANTQCETLLGARNKVKGNTKAVPKAGTGAGTRDSAQPQIVAGSQ---
-------------------------------------GETLPTARDKAMPSSEAEATAED
EVYAKPE--AEAMPISENEGGSGAQACRKTQPDIHDYYWNGIGVEDWIAAERWIKFRFQT
MDGDWENGVTWADDENEASTGSWSGA-SDK--AGIISSWAVAC----DEASVKSWAGARA
ENEVSIGTWVRAG-EQASGGLWVGGQTSEGTWAGD------------KASGGAWTVAENQ
ASGGAWVVTGNQAFGEIWAVGQASDGSWPGGQASGVSWVGEQAIGGSWTG--------AE
NQASGGSWAVV------------------------GAGNMSSVSYWAGVVDQASG-GSWA
GI------------SDQSGGGSKPRFEDQASGEGSWAGAGGQASGGSRLGPEEQSSGRSW
PDTADQASGGSRLGHVDQTSGG--------------------------------------
----------SWVGTLDHSGGGSKPRFENQTTEKG-LWAGAGGQAG-GSKLGPEDQCSGR
SWANSGDQISGGFLVGVVDQANGGSWTGA----GHLASGGPKPIFEDQASGGGSWA-NAG
DQAVGDPRLGPRDQSSGDSWAGTGDQASG------------WF-------------CVCP
G---SQ-MNGGSWGAASGQDVGGSRPGPTNQSSAVSWDSTGSQVSGSSWTGVRAVDQAGG
CSKPGFEDQAIGGVFWPGAGDQAGGGSRPGSEDQS--SGRGSWGMAGGQVL---------
------------------------------------GGSRPGPADQSSGGSWAGTG---N
QSNGRSWIGPG--DQ-AGDCSKPEFENQ-ACGGGSWAGAGSQASGESWAGSRSGNE----
---ATEG-----S--KM-----------------GSE-----------------------
--------------------------DQASGGSWARSEDQASGRFQVSVEVEANEGFWFG
PGAEAVIGSWCWTEEK-VIVSRPDDKDEATTESRSGAGEEAIICSRIEAE------NKAS
SGSWIRSEEVA--------YMGSSVGAEAGAEAGAGAGA--------WSWDGAA------
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-------------TTI-----------------------------ESRLGAEAGAGAWSW
DGEI------------------------TTIESRLGAREEVGV-----------------
---ESWTLAQD------V-DEDDLSRESSP-DI-EEIS----------------------
-LRSLFWAESENSNKFRSK--------SEKD--VNFESGAGDNT-RIKDKFEA-------
-AGGVDIESWFCDGNENTSED-KSAPKGKGNKSPE-S----------RGTYPSM-VPGAG
MGLW----DGTMIWSETK--FP------------HH--SEASFPVED----E-----SK-
KQ-T-----------------------------------KT------------GEKTRSW
SCHCKR------EANMDPQDFEKLICMIEMTEDPSVHEIANNALYNSADYPYSR------
----------EVVRNVGGISVIESLLNNPYPSV------RQ-KALNALNNI-SVAAENHR
QVKTYLNQVCEDTVTYPLNSNVQLAGLRLIRHLTITSEYQHMVTNYISEF-LRLLTVGSG
E-TK-DHVLGMLLNFSKNPSMTKDLLIAN---APTSLINIFSKKETK----------ENI
LNALSLFENINYHFKRRAKAFTQ--------DK-FSE--NSLY-FLFQRPKACAKKLRAL
AAECNDPEVKERVELLISKL----------------------------------------
-------------------------------------------

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---------------------------------------MPGTKN--KAKTQAKNEKR-T
NVQAKSGAEREATGT------TKPV---------------------TKTRSKAKAKARPK
-----TDAV---------------------------------------------------
------AETKAI-------------SKNRVVAENKEGALSEPKAPVKAM-----------
-----ANI----------------------------SPKADNEATSSTCKDNASVDTWFW
AGEE------------------------ASINSWFWKGDEASN-RTSA------------
---------KDENKA------HVGGQ--VR----P-------------------------
------------ELEPTPGVSSKNRSGDEE------------------------------
EEEENVIGSWFWEGDDASFDP-NPKPVSRIVRPQP---VDEINEKNRPKDWSEVTIWPKA
PAVTP---AVLGFRSQVPSEPKPSS----YIVLASSEEAAHSSA--------AAACSSRS
ARSNLQPIPEYPFGSDPCI--------------------QTIDEIRRQIKIREVNGIKPF
ACPCKM------ECYMDSEEFEKLIGILKSTTDPLIHKIAQIAMGIHNVHPFAQ------
----------EFINEVGVVTLIESLLSFPSTEM-------RKKTVITL-NP-PSGDERQR
KLELHVKHMCKETMSFPLDSPGQQSGLKILGQLTTDTIHHYIVASYFSEL-FHLLSQGNR
K-TR-NLVLKVLLNMSENPTAARDMINMK---ALAALKLIFNQNEAK----------ANL
VSAVAIFINIKEHIRKGSIVVVD----------HMSY--NTLT-AIFRDVKGIIKAM---
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------------------------------------------------------RGKFNF
PYKID--------DVLGTNDLQKVLNILERSNDPFTQEVALVTLGNNAAYSFNQ------
----------NAIRELGGLPIIAKLIKTKDPII------RE-KAYNALNNL-SVNVENQG
KIKTYIIQVCDDTMICRLDSAVQMAGLRLLTNMTVTNHYQHLLSYSFPDL-FALLFLGNY
F-TK-VQIMKLIINFTENPAMTRELVSCK---VPSELISLFNKEWDR----------EIL
LNILTLFENINDNIKNEGLASS---------RKEFSR--SSLFF-LFKESGVCVKKIKAL
A-NHSDLVVKVKVLKVLTKL----------------------------------------
-------------------------------------------

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-------MTRAETEPTAQVEPSKKDGEVV---------N-----------VAEIENEVPL
VVRPKV--------------------------RTQTHVMTGARPKTKTKFMPGARSKT--
------------------------------------------------------------
------------------------------------------------E------SGTRD
GTRSKN--KSKAIPRSRCKNGS--------------Q--------------AWAQNKCG-
-----AESISKRGEESHTNSIASPLANTDS--ELIGNTRCLPIDGEVVNVNTERFSRKKV
HPQMGFQPSFGSE-EITN------------------------------------------
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---IGSWCCPRSTSK-EEAFQNPDFKWVDKSSVNSWFCSEDEVSPTFRPRNRIKA-STRS
RYMAKQE-----A--NTMYRHKCKQELYFVS-SSGSE-----------------------
-DESVKTSWFWARDKTNTWS--MSMEES-NSMSHFSSKKEVPV------------DSSSG
SEYENNMKSRFRAGEEGKSSSKPRTRKEANTRTRHRARRETGNDVMPGSI------DIIK
EESWLWPREKA---------NIF-----LKPKTKKETRARTVAK----------------
EE----ARARARARVGQEAMS-----EEEVLIGTWFWDTEEASMEDVAIIKSSPHLEDEP
IVGNWFWTEE-ANMGTGPSSKL-RLRAEEKPVVDSCLETE-ENVSMEIGTETASDSMLAA
NDE-EIFVGSWFWAGEE-VN---------------------------------QEADEES
IFGSWFWGIDEAS-GESSVGVSYE-------------------------------SILR-
-SEEQEIIDPWFWDTK-VSIDTGIEEM----------SKPE-PEEKVFVSWLWSENQNHI
DSG------AEANCDIITRDN----DEEPTIGPWFWAKIDACAEAEVNSKSTLENEKE-D
IVSSWLEAGEQARMKYGPGPRFKRMAEAEDTDNSSCFWAEEGSYMYPIDRENWESRPEEE
-----EN---NRLWSKKYAGPEADVG------------------------SLLWASQEGS
IDNETGE-VKLQTEEENTITPWIWKEE-EAMIETTDRE-SWPEA-EEDLIGSWFWAGEED
RLEVPTDVREENRLSGEEE-VTVGSWFWANEESIRD-SESCSKNSSKADEEEVIIGSWFW
EEESSLEAVTGDSFQSKPDPEEE----EVIVGSWFWSKE-DSVDTGSLAVEETMPKTEEE
AIFGPWFWAEKE-----NIV----------------------------------------
----------------------------------EFGSGSQDEVNINTGDGANCESTTVP
DVDEAIFGSWFWAGDEAHFET-NPSSVFKAIGKSNCSFNQEPDPSHRPQTWDEVTVQFKS
-GPW----GWVGFPSISPLKFPKEA-AFLFCEMFGGKSKYVELKEES-----------L-
--QQ--SEQEFPFQYDPSY--------------------RSVQGIREHLKARESTEPEKW
SCSCIQ-----CHLRIDSEEFEELLLLMDRVRDPFIHEICKIAMGMRSASPFTR------
----------DFLRDSGVVSLIETLLNYPSSRV------RT-AFLENMIHM-APTYPNLN
IIQTYVCQVCEETLAYSLDSPEQLSGLMMIRHLTTTTDYHTLVVNYMSGF-LFLLTVGNT
K-TR-FHILKMLLNLSKNLTMTKELLSTE---SASGFIDLFNREETN----------ENI
QIVLAIFENIGNNIKKETEFTDDDDD-----DDDFCL--ETLT-STFHEVETFAKKLQSK
INSQNHP-----------------------------------------------------
-------------------------------------------

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-----------------------------MAGAR--NRRNRNRKN--ENKKKAKTEKR-A
VVEAE--GKREATAT------VKSAEGKREATG------------AGKTQAKAITKAGPR
-----ADAG---------------------------------------------------
------AVVKAA-------------SKNKTGTETKE-RLPAVRPKAEDEATR---AARFC
SA---AQA----------------------------TAES-----RLTCKDKTRTDTLFG
AGEE------------------------ANVGSWFWNGEKIGK-HFSA------------
---------KDEGK-------ADTGPPSCA----E-------------------------
------------KLEPVAGTSCKARPGAEE------------------------------
EEEENVIGSWFWDGDETSFDP-NPRPVSRIIKPQP---VDEINEKDRPKDWSEVTIWPKA
PAVTP---AVLGFRSQVTFEKKPPS----YFVLASAEENTCSSPVA-----TAAARPSRS
TPSSSQPVSEFPFGSDPCI--------------------QTIEEIRRQIRIREVNGIKPF
ACPCKM------ECYMDSEEFERLITLLKSTTDPLIHKIAQIAMGIINVHPFAQ------
----------EFINEVGVVTLIESLLSFPSSEM-------RKKAVITL-NP-PSGDERQR
KVELHVKHMCKETISFPLNSPGQQSGLKILGQLTTDSNHHHIVANYFSEL-FHLLSLGNR
K-TR-NLVLKVLLNMSENPTAARDMTNTE---SLAALKLIFNQKEAK----------ANL
VSAVAIFINIKEHIRKGSIVVVD----------HSSY--TTLM-AIFREVKVIIETM---
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-------------------------------------------

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-----------------------MAGSGTKAKTRGEAEAGLKAG--------ISGS----
------DNARVKAETQAKAVA-----EAEPKTELV----TQVKAGDGAIARTQAMTYTEA
--VAKTREVSNM------------------------------------------------
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-----------EDMTKTRVMDETKTKALASALNQVPQTKSKAMPVSRV--SAVT-IEVRV
G-----------------------------------------------------------
-------TGSETNIRSCAKVD-----DKANVGSRPET-----------------------
--------KEEA------------------------------------------------
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-----------TGIGI-----------------------------KSSDEDEENVCSWFW
SGEE------------------------PSVGSWFWPEEETPPQV---------------
-----YKPLPK---------------------I-QEMP----------------------
------------------------------------------------------------
----------------------KSPPT------------------------PKLTTKQKA
-KAW----LRA--RYIVLVPVE------------GE--EQS-LPP---------EGDWTL
IDTLIET--------PLGIRPLTKIPPYGGPYFQTLAE------IKKQIRQREKYGPNPK
ACRCKS-----RGFSLEPEEFDKLVALLKLTRDPFIHEIATMTMGISPAYPFTQ------
----------DIIHDVGITVMIENLVKNPNIKE------HP-RALSMVDDS-SESPEEPK
VGESYIHQVCKDVMSYPLNSPLQLAELKLLAHLSVNFEDHHVIANYIPDF-LTLLNKGSV
K-IK-FYVLKVFLCLSKNQANTRELISAE---VLSSLVAPFNKNESK----------ANI
LNIIEIFENINFQFKKRGKLFTK--------EK-FTK--SELI-SIFQEAKEFGQKLQDL
A-EHSDPEVRDKVIRLILKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
--------------------------------------------MGRVQEVGWATAGLAI
WAGTCYYLYKLTKGRAQSVTRLARNGSSV-KMDTVVG----VQDQPLPMSEAMAGVEIET
RPKDKNGAENE-GNEPGAEVETKVTAVERSKANSQ----SKAMIGAKTETQFE-------
AKSVAKALVMIDAVTLTEAQ--VKAREVAMKEVMTQTDSEAGEIVKKEAVTQTK-AKAWA
LVSRTEARKEATTQTKAETQTLAEKETEINRVTVTQSEVLAVTKE----VVKIGTMNKSG
IVVESKTRALEETVSVVTTQSDGRLGNTGDARKSPNGMSRAVADMDVKSCVQSQAVVKIQ
DGDMLIAEVEDKGNLK---------------------------TMPKAGSEVDTRAAPQP
QIVVRTQAEAMPGTRVDMAGSFATMYKAEVGPNVRACIMQPQTIAKKQAEALSGAQ-VDG
RENTTVISKAITGAVIQTAAQIQAVTCAQAESVPDARVKGRGNSHATVKAGGTPNMRTNV
QAEALSDNSHKARSLSSVTIKAEVGIDTLSYT-QTQPVANVQSDALPDGRIKTKGTVNSM
IKEGAQG--------MAQNQGEALLNTKGKARGKAKAKCKTGVAPDMKTCSQPQAGTKTQ
AEVLPDSKIDGRGDSNGISKAGT---NRTCGQLQAVVNSQVEALPSTKNKLKTYPNAVPK
AEAGTAAADCAQPQVVVCSQSETLIANKVK------------------------------
------------------------------------------------------------
-------------------------------CNLSVIPKTEAVV----------------
------------------------CMTGSAFSQALANSQGDT------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------LTGTRSKVKGNPIAVAKPEIGPGMT--
--------------------------------------DSFQSLIMTNSQNETLLGARSK
VR----------------------------------------VNCNVP-KAEVGAGS---
----TVVGSQGETLLGARNKVRSSPNAVPKAE-----AVAGLVSSSQSQTLTSSQNEALL
GARNKVRGNSSTVPKSGPQKGTKVPAQPQVMVASQ-------------------------
------------------------------------------------------------
-------------------------------------DEVLLGVMDKAMSRSEAEATAED
KVYAKPEAEAEAMLISE-----------TCRKNLHDYYWNGIGVEDWIAAERWIKFRFQA
MDGDWENSVSWADDKNETNIGSWSGT-GDR--SGFVSSWAVAC----DETTIKSWAGARA
ENEVALGSWVGTG-DQASGGLWAAGQVSEASWTGD------------KAIGGSWPGTENQ
VSGASWVVPGNQTIGAPWAVGQVSDMSWPGVQATGVSWVVDQASGGSWTV--------AE
NQASAVSWAGA--------------------------GNIVSIGYWTGAMDQANA-GSWI
GT------------GDPSGSESKPQIEDQASDKRSWAEAGGQANGDSSLAPENQSNGRSW
DDTADQASRGSRLGPVDQPSGASWAGAMEQAGSGSTPGSEDQSSGASWDGTRNL------
------AREGSWTGTGDQSSGESKPSFKNQASDEG-SWAGAFGQAAGVSKSGPEDQSNGR
SWTDFGDQISGSFLVGVVEQADGKSQASP----GDLAAVGAKPVFEDQASGGGCWTSVAE
DQSGRESKPGPREQSSGDSWPGTGDQASG------------WF-------------CAYT
G---IQASGAGSWGGTGGQDIGVSRPGPMNQASSASWSGTGSQISGVSWPV------AGG
CPKPGFGNQALAAGFWAGAGNQADTGPRPESEDQS--SARGSWPVTGVHVI---------
------------------------------------GASRPDPTDQCSGASWAGPG---N
QASGGSWVGPG--DQ-AV--------------GSAWAGPGDQASAVSWPVSRPRNE----
---ASA------------------------------------------------------
-------------------------------GSRLGSEDQTSGRFLVSAEVEANEGFWFG
PGSEAFIGSWCWTGEEVGIVPRADGKDETSIECTSGPKEETIISAELGDE------NKSS
VGSWIRSEEAV--------YV----DPCVRAESGSETGAAAEAE--AGIEAEAGAE----
-----------------------------------------------------------A
VDE--------AGAGAEA----------------------------------V-------
--------------GVAAA-----------------------------------------
-------------------AAVSDAEA------V-------------DDID--SEAKAGV
EDVAKAEGVAVAEAEAEAEAEAVAGAEAVAVA----------VAE---------------
-----------------AVAG-----DEAVA----------------VAVAEAVAVAE-A
VAEAVAGAVTVA----------------GAET----------------------------
------------------------------------------------------------
----------------------------------------------E--AGA--EA----
--EAEAVAEAEAEAEP-----------------------------GAEAGAEAIMGSWSW
DAQV------------------------ATKEPGLWAKEKAGI-----------------
---RSWVLPRD------V-DEDELSEASSP-DI-EEIS----------------------
-LRSLFWAESENSSEFRCN--------SGKD--INFESVFGEEA-SIMDKFEA-------
-DDGVDIRSWFCTGNESRSED-QSTHKAKAKKSAE-A----------RGTYPSM-VPGAG
MGSW----DGAMIWSEMK--FS------------QQ--SEAGFPAGD----E-----FT-
QQ-N-----------------------------------RA------------GDKVQPW
SCRCKE------EANMDPRDLEKLICMIEMTEDPSVHEIANNALYNSIDYPYSH------
----------EVVRNVGGISVIESLLNNPYPSV------RQ-KALNALNNI-SVAAENHR
KVKTYLNQVCEDTVTYPLNSNVQLAGLRLIRHLTITSEYQHMVTNYISEF-LRLLTVGSG
E-TK-DHVLGMLVNFSKNPSMTKDLLIAN---APTSLINIFSKKETK----------ENI
LNALSLFENINYHFKRRAKAFTQ--------DK-FSK--NSLY-FLFQRPKACAKKLRAL
AAECSDPEVKERVEILINKL----------------------------------------
-------------------------------------------

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---------------------------------MGGPRGAGWVAAG----------LLLG
AGACYCIYRLT--RGRRQ-GDR---------ELGKRP--SK-------------------
------------------------------------------SA----------------
------------------------------------------------------------
--------------------------------GILE---EG-------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------TS-------------------------------
------------------KGQ-L----CGRS--------------AR---------P-QR
GG---------------TWESQ------------WSKTSQ--------------------
-----------PE--------------------------------------------DLT
DGSYD--------DVLNAAQLQKLLYLLESTEDPVIIERALITLGNNAAFSVNQ------
----------AIIRELGGIPIVGNKINHSNQSI------KE-KALNALNNL-SVNVENQI
KIKIYINQVCEDVFSGPLNSAVQLAGLRLLTNMTVTNDHQHMLHNYITDL-FQVLLTGNG
N-TK-VQVLKLLLNLSENPAMTEGLLHAQ---VDSSFLSLYDSHVAK----------EIL
LRVLTLFQNINNCLKIEGHLAV---------QPTFTE--GSLFFLLHGE--ECAQKIKAL
V-DHHDAEVKEKVLTIIPKI----------------------------------------
-------------------------------------------

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--------------------------------------M---R-----------------
--------------------------------------------------DSALKAGLVG
LAV------GAGVCLALYGLA-------------SR--RRRRRKGAD----PGER--DRS
AL-L-----------------------------------RA-------AS--GIPLVSSS
GRREQGMDFPNSPHVLETDDVQNLIYLLESTKDAAIQEQILITLSNSAAFSINQ------
----------DTIRNLGGLPVVGKMLSVPVANV------KE-KALNALNNL-SMNIQNQE
VIKVYIAKVCEETCSAPLNSELQLAGLRLLTNMSVTNNYHYMMTSSIPGF-INLLSAGNE
R-TQ-VQVLKVLVNLSANPAMTEHLLKAQ---A-SFLLSLFDSCIKE----------DVL
LRLLVFVTNLTKHMKKD-KNTVN--------YE-YNE--DSVFSVLWGDSTVCAQKLASL
F-HHHDAEVRLQVAALIRQQC---------------------------------------
-------------------------------------------

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---------------------------------------MTGSKN--KARAQAKLDKR-A
SGQAKALAEREAANA------GRAG---------------------GKNRDKGKPKWGNK
-----ADAA---------------------------------------------------
------SETRGG-------------SKGRAAAEMKEGGRSEHKALGKD------------
-------F----------------------------NHKYEYKGARSSRKEKASSDTWFW
TGEE------------------------SGLNSWFWKGEEVSY-DTVP------------
---------QCENK-------SNTGTQGRT----E-------------------------
------------ESEPTPKASHKSR--AEE------------------------------
EEEENVIGNWFWEGDDTSYDP-NPKPVFRIVKPQP---VDEINEKNRPKDWSEVTIWPKA
PAVTP---AVLGYTSQDSSESRPSS----FIVLASNEEKASK------------TACTKN
TRSGLQPIPEYPFGSDPCI--------------------QTLDEIRQQIKIREMNGIKPF
ACPCKV------ECYLDSPEFEKLVNILKSTTDPLIHKIAQIAMGLHKVHPFAR------
----------EFINEVGVVTLIESLLSFSSPET-------RKKTVITL-N--SSGDDRQH
KVEFHVKHMCKETVSFPLNSPGQQSGLKIIGQLTTESVHHYIVASYFSEL-FHLLSQGNR
K-TR-NLVLKVFLNMSENPKAARDMINMK---ALAALKLIFNQKEAK----------ANL
VSAVAIFINIKEHIRKGSIVVVD----------HLSY--STLT-AIFREVKGIIERM---
------------------------------------------------------------
-------------------------------------------

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-----------------------------------------------MGRARE--VGWMA
AGLM----IGAGACYCVYKLTI------------GR--DDSEKLEE------EEEEEWDD
DQELEEEEPDIWFDFETMARPWSEDGDWTEPGAPGGTEDRPSGGGKANRA--HPIKQRPF
PYEHK--------NTWSAQNCKNGSCVLDLSKCLFIQGKLLFAEPKDAGFPFSQ------
----------GINSHLASLSMVRNTSPTPDPTV------R--EALCATDNL-NASIESEG
QIKMYINEVCQETVSRCCNSFLQQAGLNLLISMTVINN---MLAKSLSDLKFPLISEGSG
C-AK-VQVLKPLMGLSEKPVLAGELVSAQ---MLFSFMSLFIRKGNR----------EIL
LETPAP------------------------------------------------------
------------------------------------------------------------
-------------------------------------------

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-----------------------MAGSGTEARAREKAEAGLKDG--------VRGP----
------AAARVSGETQAKSVA-----EAKLKTESV----TQAKAGDGAMARTHTVTYTVT
--MAVTREESRM------------------------------------------------
------------------------------------------------------------
-----------EDTTKTRVVVETKAKPLA-EHSIVPQTKSKAMPMSRV--SAVTKSEVKV
V-----------------------------------------------------------
-------AVSEADIRSYTKSH-----DKANTGSRPDR-----------------------
--------REEA------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------SIGM-----------------------------KSSDEDEENICSWFW
TGEE------------------------PSVGSWFWPEEETSPQV---------------
-----YKPLPK---------------------I-QEKP----------------------
------------------------------------------------------------
----------------------KPTPK------------------------PMLTIKQKA
-IAW----SRA--RYIVLVPIE------------GG--EQS-LPP---------EGNWTL
VETLIET--------PLGIRPLTKIPPYHGPYFQTLAE------IKKQIKQREKYGPNPK
ACRCKS-----HAFSLEPKEFDKLVALLKLTKDPFIHQIATMIMGISPAYPFTQ------
----------DIIHDVGITVMIENLVNNPNVKE------HP-RALSTVDDS-SESSKEPK
AEESYIHQVCKDIVSCPLNSPVQLTGLKLLGHLSVKFEDHYVITSYIPDF-LTLLNKGSV
K-TK-FYVLKVFLCLSKNQANTRELVSAK---VLSSLVAPFNKNESK----------ANI
LNIIEIFENINFQFKTKAKLFTK--------EK-FTK--SELI-SIFQEAKQFGQKLQDL
A-EHSDPEVRDKVIRLILKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
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-----------------------MVDSGTEARARGKAEAGLQDG--------ISGP----
------AAARVNGKTQAKAVA-----EAELKTESV----TQAKAGDGAMTRTHTVTYREA
--MAVTREVIKV------------------------------------------------
------------------------------------------------------------
-----------EDTTKTRVMVETKTKPLA-ERSIVPQTKSKAMPMSRV--STVTKSEVKV
V-----------------------------------------------------------
-------AVIEANIRSYAQSH-----DKANTGSRPDR-----------------------
--------REEA------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------SIGM-----------------------------KSSDEDEENICSWFW
TGEE------------------------PSVGSWFWPEEETSLQV---------------
-----YKPLPK---------------------I-QEKP----------------------
------------------------------------------------------------
----------------------KPTHK------------------------PTLTIKQKV
-IAW----SRA--RYIVLVPVE------------GG--EQS-LPP---------EGNWTL
VETLIET--------PLGIRPLTKIPPYHGPYYQTLAE------IKKQIRQREKYGPNPK
ACHCKS-----RGFSLEPKEFDKLVALLKLTKDPFIHEIATMIMGISPAYPFTQ------
----------DIIHDVGITVMIENLVNNPNVKE------HP-GALSMVDDS-SESSEEPK
SGESYIHQVCKGIISCPLNSPVQLAGLKLLGHLSIKFEDHYVITSYIPDF-LTLLNKGSV
K-TK-FYVLKVFSCLSKNHANTRELISAK---VLSSLVAPFNKNESK----------ANI
LNIIEIFENINFQFKTKAKLFTK--------EK-FTK--SELI-SIFQEAKQFGQKLQDL
A-EHSDPEVRDKVIRLILKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
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---------------------------------------------------------DLT
NGSYN--------DVLNAEQLRKLLYLLESTEDPIITXXXXXXX---XSTVIQQ------
----------AIIRELGGIPIIGSKINSPNHSI------KE-KALNALNNL-SVNVENQI
KIKVFVSRVCEDVLSSPPDSAAQLAGLRLLTNMTVTNAHQHLLSAAVADL-FGLLLAANG
N-TK-VQVLKLLVNLSENPAMTEGLLSAQ---VDASFLSLFDGHVAQ----------EIL
LRVLTLFQNINNCLRVE---AV---------QPPFPE--GSLFSLLYGE--ECVQKMKAL
V-NHHEVDVREKAVTIIPKF----------------------------------------
-------------------------------------------

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-----------------------MVDSGTEARARGKAEAGLQDG--------ISGP----
------ATARVNGKTQAEAVA-----EAELKTESV----TQAKAGDGAMTRTHTVTYREA
--MAVTREVIKV------------------------------------------------
------------------------------------------------------------
-----------EDTTKTRVMVETKTKPLA-ERSIVPQTKSKAMPMSRV--STVTKSEVKV
V-----------------------------------------------------------
-------AVIEANIRSYAKSH-----DKANTGSRPDR-----------------------
--------REET------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------SIGM-----------------------------KSSDEDEENICSWFW
TGEE------------------------PSVGSWFWPEEETSLQV---------------
-----YKPLPK---------------------I-QEKP----------------------
------------------------------------------------------------
----------------------KPTHK------------------------PTLTIKQKV
-IAW----SRA--RYIVLVPVE------------GG--EQS-LPP---------EGNWTL
VETLIET--------PLGIRPLTKIPPYHGPYYQTLAE------IKKQIRQREKYGPNPK
ACHCKS-----RGFSLEPKEFDKLVALLKLTKDPFIHEIATMIMGISPAYPFTQ------
----------DIIHDVGITVMIENLVNNPNVKE------HP-GALSMVDDS-SESSEEPK
SGESYIHQVCKGIISCPLNSPVQLAGLKLLGHLSIKFEDHYVITSYIPDF-LTLLNKGSV
K-TK-FYVLKVFSCLSKNHANTRELISAK---VLSSLVAPFNKNESK----------ANI
LNIIEIFENINFQFKTKAKLFTK--------EK-FTK--SELI-SIFQEAKQFGQKLQDL
A-EHSDPEVRDKVIRLILKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
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---------------------------------------------------------DLT
NGSYD--------DVLNAEQLQKLLYLLESTEDPAIIERALVTVGNSAAFSANQ------
----------VVIRELGGIPVVGSKINSPNQSI------KE-KALNALNNL-SVNVENQI
KIKVYVNQVCEDVLSGPLNSAVQLAGLRLLTNMTVTNDHQHMLRSYITDL-FHVLLTGNG
S-TK-VQVLKLLLNLSENPAMTDGLLGAQ---VDSSFLSLYDGHVAK----------EIL
LRVLTLFQNINNCLKKEGCLVI---------GPTFTK--GSLFYLLYGE--ECAQKMRAL
V-YHQDADVKEKVTM-LPKNW---------------------------------------
-------------------------------------------

------------------------------------------------------------
--------------------------------------------MGRVQEVGWVTAGLVI
WAGTCYFIYKLTKGRAQSVRRLARNGSRV-KMETVVG----VQNQTLATSEAM----IEI
RPKAKNGAETGAGDGPGAEVETKDTAIAILKANSQ----AKAMGGTEAEIQSE-------
AKVMAGTLIMTEAVTLTEAK--AKAKEVAVKEAVTQTDAKAGRVVKKEAVTQTK-AKAWA
QAARAEAKKEAMTQTKAEAHILAEKTPEINRVMATHSEILAVTRE----VDKMGAMNKTG
IVTETKTRALEETVSVAKIQSEARPGATVDARENLNGLSREVTGVNVKSSTQSQAVTKVQ
GDDVPGTGVEDKGNSK---------------------------TMSTAGSGIDTMASVRL
QIVAKTQDETMPGARIDAGGNTNAMCMVGAGADVRACV-QSQTVVKKQAEATSGAR-VDD
RGNTNVRSKTITGADMRAAAQPQAVASTQAEATPDVRVKGRGNSNALAKAGARANLRASS
QVEALPNARDKSRGNPNVMAKAGVGTDMLSCT-QSQPVANVQADTMPDGRIKAKGNTNTM
SKEGAGTDTKTQAQAMVQSQGEALPNTRGKTRGKTKSKCKAGLGTDVKSCAQPQAGAKAQ
AEALPDSMVDGRGDPNAISRAVAKADQRTCGQPQVVANPQDEALPIAKNRVKGNPN-VPK
AGSGEGTMDSAQPQAV---------------------------------------ANSQG
EALLGTKNKVRSNPNAVSKAGVGAGTTGSAQLQVVANSQAEALPDIKNKVKNNSNVVSKA
GAGKDITGSAQSHVVANSQGEVLPGAKNKVRGSSNAVPNVGPGPNT--------------
--------------------------TDSAQPQAVANSQDEALPGAKNKLKGNHHAVSKA
ETGIG-------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------AM--
--------------------------------------DSAQPHAVTNSQGEALPGVKNK
VRGNRKSVSKAGTGADTTGSSQSQAVFNFQGEILSGAKNKVKGNLNAVSKAEPEMGITGS
TQSQAMANSQSEALPVVKNKVKGNSNVMPKTG-----TGEDTMASAQPHVVAKSQNEALP
GTRNKVKGNSSAMSKTETGTGTVGSAQPQAVTNSQGGALPGTKNKVKGN--PNAVPKVEA
GADTMSFAWPQTVTDSQNETLLGARNKVRGNPNVVPKAGATAGTGDSAQPQIVARSQ---
-------------------------------------GETLPGARDKVMFSSETEATVDG
-VHAKP--EAEAMPTSESESGSGTQACRNTQPYIHDYYWNGIGVEDWIAAERWIKFRFQA
MDEDWENSMSWADDENEASIESWSGA-SDK--AGI-TSWAVAC----GEASMKSWTGARA
ENEVDIGSWTGVG-DQASGGLWVGGQVSEESWAGD------------KAIGGSWTGAENQ
ATGGSWVVSGNQAIGELWAGGQASEGSWPGGQASGVSWAGEEAIGGSWTG--------VE
SQASGGSWAGA--------------------------GNIGSVGYWAGTVDQTSG-GSWA
VT------------GDHSGGGSKPGFEDQSGEKGSWARTGGQASEGSKLGSEDQSSGRSW
ADTTDQASGGSRLGHIDQSSGG--------------------------------------
--------AGSWAVTGDQSVGKFKSRLENQTSEEG-SWAVAGGQVGGGSKLGPEDSSSGR
SWTSSGDQISGGFLLGVVDQANGGSWVGA----GDLVSGGTKPIYEDQASVKGSWA-VAG
DQAGGGSMLGPRDQSSGDSWVGTGNQASG------------WY-------------CVCP
G---SQTNGGESWGGAVGQDIGVSRPGPTSQSSGGSWTGTGSQVSGGSWAGT--VDQAGG
CSRPVFEDQTIGGGFWAGAGDQASGGSRPELEDQS--SGGGPWCLAGGQVV---------
------------------------------------GGSRPGPSGQSSGRSWAGTG---S
QVSGGSWAGAGAVDQ-ADDCSKPEFENQ-ACGRGSWTGTGNQVSRESWAGSRPENE----
---ASGG-----S--R-----------------LGPEDQA--------------------
-----------------------------TGGSWARSEEQVSGQFQVSFEMEANEEFWFG
PGAEAVIGSWCWSEEKADIVPRLEDKDEASTESRSGTGKESIVSSRFETE------NKAS
IGSWIRSDEAA--------YM----GSCVGAEAGAETGAEAV------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----TEAVAEAGAEA-----------------------------GAEAGAEARLGSWSW
DGNA------------------------TTTKSRHGTGEEAGI-----------------
---GSWTLARD------V-DEDELSRESSP-DI-EEIS----------------------
-LRSLFWAESENSNEFRSK--------CRKD--VNFESGTGDKA-SIKDKFEA-------
-AGEVDIRSWFCED--------KSASKDKAKKSAE-S----------RGTYPSM-VPGAG
MGSW----DGAMIWSETK--LP------------HP--NEASFLAED----E-----VK-
KQ-M-----------------------------------KS------------GEKIRPL
SRRCKH------DANMDPRDLEKLICMIEMTETPSVHEIANNALYNSADFPYPH------
----------EVVRNVGGVSVIESLLNNPYPNI------RQ-KALNALNNI-SVAAENHR
TVKTYLNQVCEDTVTYPLNSNVQLAGLRLIKHLTITSEYQHMVTNYISEF-LRLLAVGSG
E-TK-DHVLGMLLNFSKNPSMTKDLLIAN---APTSLINIFNKKETK----------ENI
LNAISLFENINYHFKRRAKTFTQ--------DK-FSK--NSLY-FLFQRPKACAKKLRAL
AAECNDPEVKERVELLISKL----------------------------------------
-------------------------------------------

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------------------------------------------------------------
------------------------------------------------------------
---------------------------------MGGPRGAGWVAAG----------LLLG
AGACYCIYRLT--RGRRR-GDR---------ELGMRP--SK-------------------
------------------------------------------SA----------------
------------------------------------------------------------
--------------------------------GILE---EG-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------TS-------------------------------
------------------KGQ-L----CGRS--------------AR---------P-QR
GG---------------TWESQ------------WSKTSQ--------------------
-----------PE--------------------------------------------DLT
DGSYD--------DVLNAAQLQKLLYLLESTEDPVIIERALITLGNNAAFSVNQ------
----------AIIRELGGIPIVGNKINHSNQSI------KE-KALNALNNL-SVNVENQI
KIKIYINQVCEDVFSGPLNSAVQLAGLRLLTNMTVTNDHQHMLHSYITDL-FQVLLTGNG
N-TK-VQVLKLLLNLSENPAMTEGLLRAQ---VDSSFLSLYDSHVAK----------EIL
LRVLTLFQNINNCLKIEGR-----------------------------------------
------------------------------------------------------------
-------------------------------------------

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------------------------------------------------------------
------------------------MTGSKANAKRGRAGAGPKAG--------ISGP----
------TNTRVKAKIQTKAVT-----EAELKTGPV----NQAKAEDGAVARKQTVTYIEA
--VAMTREVNKM------------------------------------------------
------------------------------------------------------------
-----------EAMT--RVMAETKAKLLA-ESGIVPPYNSKAMPTSRV--SAVTKYEVKA
D-----------------------------------------------------------
-------AGSEATIRSFAKAD-----DKANIGSRPQR-----------------------
--------EREGSIKIE----------PS-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------DEDEKNICSWFW
TGEE------------------------PSLGSWFWPEEENPYQV---------------
-----YKPPPK---------------------I-QEKP----------------------
------------------------------------------------------------
----------------------KPT--PK----------------------HELTIKQKA
-AAW----SRA--RYSVLVPIE------------GG--EQS-LPP---------ERNWTL
VETLIET--------PLGIRPLTKIPPYNGPYFQTLAE------IKEQVRSREKYGPNPK
ACRCKS-----RAFSLEPKEFDKLIALLKLTKDPFIHEIAKMIMGISPAYPFTQ------
----------DIIHDVGITVLIENLVNNPNVKG------HA-RASNMVDEN-SESSEESK
IGESYIHQVCKDVISCPLNSPVQLAGLKLLEHLSVKFEDHHMIANYIPDF-LTLLNKGSV
K-TK-FYVLKVFLRLSKNQANTRELISAK---VLSSLVAPFNKNESK----------ANI
LNIIEIFENINFQFKKKVKLFTK--------EE-FTK--SELI-SIFQEAKEFGQKLQDL
A-EHSDPEVRDKVTRLILKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
---------------------------------MGRTREAGCVAAG----------VVIG
AGACYCVYRLT--WGRDE-NEKIWD----DDQESSDT--SEAATE---------------
---------------------------------TG------KGVKANIGAGSGAKVQGYS
-----------------------------NA------------KAEVSLGLESGAGVKEE
SRS----------------A--------SQSGGGLE---AKA------------------
-----------------KALFST-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------L----------------------------------
----------------KEQASAKAGRGGRVGTIS--------------------------
---------------------------------------------GNRTLGPSLPCPGGR
GG---------GCHPSRSGARA---------------------------------GGRSS
GKSKGKTRSKSTRTPA-T---------------------------TW----PVRRGKFNF
PYKID--------DILSAPDLQKVLNILDRTNDPFTQEVALVTLGNNAAYSFNQ------
----------NAIRELGGVPIIAKLIKTKDPII------RE-KTYNALNNL-SVNAENQG
KIKTYISQVCDDTMVCRLDSAVQMAGLRLLTNMTVTNHYQHLLSYSFPDF-FALLFLGNH
F-TK-IQIMKLIINFTENPAMTRELVSCK---VPSELISLFNKEWDR----------EIL
LNILTLFENINDNIKSEGLASS---------RKEFSR--SSLFF-LFKESGVCVKKIKAL
A-NHKDLVVKVKVLKVLTKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
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---------------------------------------VGWVTAG----------LVIG
AGACYCIYRLT--RGRKQSKEK-MS----EGGFGDVD--DAG----------------DC
---------------------------------------------------------SRA
--RYNK-----------------------------------------------------D
DDN----------------N--------E-------------------------------
------------------------------------------------------------
-SKSMGWYSPWAQ-----------------------------------------------
------------------------------------IG----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------T--------------------------------
-----------EAGTRARARA---------------------------------------
------------------------------------------------------------
---------RARKC-------------------------------------IHYLAHVIV
APLYG--------IFTIIIIIKKVLCLVEMSGKPYILEAALIALDNNASYAFDR------
----------HIIDDLGGLPIVAKILNTWDPIA------KG-KALIILNNL-SVNTENQC
---------------------------RLLTNMTVTNEYQHILANSISDF-FRLILAGNE
E-TK-LQVLKLILNLAENPAMTRELLR----------------KENK----------EVI
LKLLIIFENINDKFKWEENEPT---------QNQFGE--GLLFV-FLKEFQVCADKVLGI
E-SHHDFLVKVKIGKFMAKLAEHMFPKNQE------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
-----------------------MVGSRDRERTRGEAEAGLKAG--------ISGS----
------SNARVKAETQAEAVA-----EAELKTELV----TQVKAGDGGIARTQTVINTEA
--VAVTMEVNKT------------------------------------------------
------------------------------------------------------------
-----------EDMTKTRVLAETKTNPPANAPNQVPSNKSKAMPVSRV--SAIT-PEVRV
G-----------------------------------------------------------
-------AGIEENIRSCAN--------KANIGSNPES-----------------------
--------RDGA--NIK----------GG-------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------AGDKAGTGV-----------------------------KFSDEDEEYVCSWFW
NGEE------------------------PSVGSWFWPEEETPPQV---------------
-----YKPLPK---------------------I-QEKP----------------------
------------------------------------------------------------
----------------------KPKPKPKSKPTH----------------KPKLTTKQKA
-IAW----SRA--RYIVLVPIE------------GG--EEF-LPP---------EGDWTL
IETLIET--------PLGIRPLTKIPPYNGPYFQTLAE------IKSQIRQREKYGPNPK
ACRCKS-----RAFSLEPKEFDKLVALLKLTRDPFIHEIATMIMGISPAYPFTQ------
----------DIVHDVGITVMIENLVNNPNAKA------HS-RDLKTVDDS-SESSQEPK
ARDLYVDQVCKDIFSYPLNSHEQLAGLKLLVNLGLNFEVHHMIANYIPDF-LTLLNKGSV
K-IK-FYVLKVFLCLSKNQANTRELISAE---VLSSLVAFFNKNESK----------ANI
LNIIEIFENINFQFKKKVKLFTK--------EK-FTK--SELI-SIFQEAKEFGQKLQDL
A-EHSDPEVRDKVIRLILKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
---------------------------------MGRTREAGCVAAG----------VVIG
AGACYCVYRLA--WGRDE-NEKIWD----EDEESTDT--SE-------------------
-----------------------------IGVETV------KGAKTNAGAGSGAKLQGDS
-----------------------------EV------------KPEVSLGLEDCPGVKEK
AHS----------------G--------SHSGGGLE---AKA------------------
-----------------KALFNT-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------L----------------------------------
----------------KEQASAKAGKGARVGTIS--------------------------
---------------------------------------------GNRTLAQSLPCPGGR
GG---------GCHPTRSGSRA---------------------------------GGRAS
GKSKGKARSKSTRAPA-T---------------------------TW----PVRRGKFNF
PYKID--------DILSAPDLQKVLNILERTNDPFIQEVALVTLGNNAAYSFNQ------
----------NAIRELGGVPIIAKLIKTKDPII------RE-KTYNALNNL-SVNAENQG
KIKTYISQVCDDTMVCRLDSAVQMAGLRLLTNMTVTNHYQHLLSYSFPDF-FALLFLGNH
F-TK-IQIMKLIINFTENPAMTRELVSCK---VPSELISLFNKEWDR----------EIL
LNILTIFENINDNIKNEGLASS---------RKEFSR--SSLFF-LFKESGVCVKKIKAL
A-NHNDLVVKVKVLKVLTKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
-------MTGAEIETGSQAKPDKKPQEEV--------MG-----------GADRESEVPM
VVRPKV--------------------------RPQAPATSGARPKTESKSSSRARPKTEP
------HSGSGT------------RPKN--------------------------------
---ARPRS----------------------------EAQVMTGARPKTD------TRAVG
GARPKT--EAKPIPGARPKDDA--------------Q--------------AWAQRE---
-------AMSRAGRAPLSNAVTWPLVNAESDSSSVTKSKSLSMDRELVNMNREPFPGTQ-
-GQAGIQPWFGPG-EGAN------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---SGSWCYPRPRAR-EETSNESGFWSADETSTMSSFWTGEETNIRSWPREET---NTRS
RHRAKHQ-----T--NARSRPRSKQEPYIDS-WSGSE-----------------------
-DEAGNPFCFWAGENTNDLF----------------------------------------
---------------------RPRGREEANVRPKIRTKREDY--FESESE------DEFY
KESWFLPGEEA----------NR-----FRRRDKEESNNILKNR----------------
NQ----NDVENSDRAKQESRF-----EEEVIIGSWFWAEQET------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------GL
EAG------ASAICESEPGAE-----EGAI------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------GGSLFWTEEKP
TLGA--------------------------------------------------------
-----------------------------------------------AAREEVRPEP---
------------------------------------------------------------
------------------------------------------------------------
-EEEAIFGSWFWDRDEACFDL-NPTPVYKAKSRFRNSA-EELNVASRPKTWDEVTVEFKP
-GIC----RGLGF----PFRIPEGDS-----ENTEAKAKNAELGAEG----E--EQESGP
QPDL--PEPEFPFQYDPSY--------------------RSVQEIRAHLKAKESADPANW
SCTCIQ-----CELKIGSAEFEELLLLMDKIRDPFIHEISKIAMGMRTASQFTR------
----------DFIRDSGVVSLIETLMNYPSSRV------RT-NFLENMIHM-APPYPNLN
MIETFICQVCEETLAHGVNSLEQLTGIRMLRHLTITTDYHTLIANYVSGF-LTLLTTGNA
R-TK-FHVLKMLLNLSENPMVAKKLFSAK---ALSIFVGLFNIEETN----------DNI
QIVIKMFQNISNIVKSGAMSLID---------DDFSL--EPLV-SAFHEFEELAKRLQIQ
IDNQNDPEEGQ-------------------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
---------------------------------MGGARDVGWVAAG----------LVLG
AGACYCIYRLT--RGPRR-GGR-----------RLRP--SR-------------------
------------------------------------------SAE---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------DLT
DGSYD--------DILNAEQLKKLLYLLESTDDPVITEKALVTLGNNAAFSTNQ------
----------AIIRELGGIPIVGNKINSLNQSI------KE-KALNALNNL-SVNVENQT
KIKIYVPQVCEDVFADPLNSAVQLAGLRLLTNMTVTNDYQHLLSGSVAGL-FHLLLLGNG
S-TK-VQVLKLLLNLSENPAMTEGLLSVQ---VDSSFLSLYDGQVAN----------EIL
LRALTLFQNINNCLKVEGRLAN---------QIPFAK--GSLFFLLYGE--ECAQKMRAL
A-CHHDVDVKEKALAIKPKF----------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
---------------------------------MSRARDAGCVAAG----------IVIG
ASAWYCVYKYT--RGKDQ-KKKRLT----KPKNRA--SVGTGSRARAGLRAGFTIDLGPG
FSPPNPVDIEIMNK-AQGEASNLATTVTEEVAPAA------PSPKVQNGAESKVQELNGA
--KT-EANTESVVMPSATCTVTPSPKVAGGL------------TAAEAPEIIGAPKVLEA
PST----------------T--------EASGAVAS-PGPTVSPMIAQSPGPVVPS----
-----------------PTIVSTG--------------PAAI------------------
---------PWAVA----------------------------------------HPGAVQ
SPGPA----------VPPMAV---QSLVPAAPSWAVVAP---------------------
-----------------PGAVYIPVAAHF-----------AGPAAAS----RVTQSPGTV
IPPLPPPSSV-------LPRGVPSVPGRTVQSPGAAVHPVAAQSTGVVVPPRAVQYSGAA
VTSGGA-----AVPSGG---------AAT------------PRAAASTQRTASTEVMQVP
RVAAATEATETPRIGTP------------------------------AMVAEASLP----
----V-----------HSGAA-----------------E-TP------------------
----------------------GASGSSK-------------------------------
-----------TAA-----TGKKAAPGAHTGAIPKAGS--ATGA---VPKGGG-------
-------G---KGGSKNRSGG-K----GKNR-------------K-NKVDVDELGMGFRP
GD---------GAAAAAAASAN------------GGQAFLAEIPES-----EEGESGWTD
TESDSDSEPDVPQRGKG----------------------------KR----TIPMHKRPF
PYEID--------EILGVRDLRKVLALLQKSDDPFIQQVALLTLSNNANYSCNQ------
----------ETIRKLGGLPIIANMINKTDPHI------KE-KALMAMNNL-SENYENQG
RLQVYMNKVMDDIMASNLNSAVQVVGLKFLTNMTITNDYQHLLVNSIANF-FRLLSQGGG
K-IK-VEILKILSNFAENPDMLKKLLGTQ---VPSSFSSLYNSYVES----------EIL
INALTLFEIIFDNLRAEVFN-----------YREFNK--GSLFY-LCTTSGVCVKKIRAL
A-NHHDLLVKVKVIKLVNKF----------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
---------------------------------MGRTREAGCVAAG----------MVIG
AGACYCVYRLT--WGKDE-NEKLWD----DEEEEEEE---EEESC---------------
------------------------S------DKPE------TGVKTNVGVGAG--PQDDS
-----------------------------KP------------KADVKVGQENDPGVKIE
AHP----------------E--------SQGEGGLE---AKA------------------
-----------------KALFKI-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------L----------------------------------
----------------KEQASAKAGRGIRFANIS--------------------------
---------------------------------------------GTRTLSSGLPCPGGR
GG---------GCHPGRSGARA---------------------------------RSRAS
GKAKRKNRSKSTKAPA-T---------------------------AW----PVRRGKFNF
PYKID--------DILSAPDLQKVLNILERTNDPFTQEVALVTLGNNAAYSFNQ------
----------NAIRELGGVPIIAKLIKTRDPII------RE-KTYNALNNL-SVNSENQG
KIKTYISQVCDDTMICRLDSAVQMAGLRLLTNMTVTNHYQHLLSYSFPDF-FALLFLGNH
F-TK-IQTMKLIINFTENPAMTRELVSCK---VPSELISLFNKEWDR----------EIL
LNILTLFENINDNIKSEGLASS---------RKEFSR--SSLFF-LFKESGVCVKKIRAL
A-NHKDLVVKVKVLKVLTKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
---------------------------------MSRVRDAGCVAAG----------IVIG
AGAWYCVHKYT--RGRDQ-KKRRLA----KPKNQA--VAGTGARARAGPRAGFTIDLGPG
FNPPTTVYAGAEDK-VQDEAPALDMAGAEAVAPAS------SSTEARSEAESLAQKADGA
--GIGPKT-ELVVGAAVTSAMAQPLGVAKAP------------TALEGSAVAEASKVAEA
PRT----------------A----------------------------------------
------------------------------------------------------------
-----------------------------------------------------------E
APRAT----------VPPEVE---MPPKA-------------------------------
-------------------------------------------AMSP----RAA------
------------------------------------------------------------
--------------------------------------VLPPGKAVSTKATAATETVEAP
GEAAPIEVAECPGMTTL------------------------------GEVAETPVSTT-P
AGAAI-----------TARAA-----------------E-IP------------------
----------------------GTSGSTR-------------------------------
-----------TA-----AVNKKATPGAHTGAIPKAGS--ATGA---VPKGGA-------
-----------KGGTRSQTGG-K----G--KS------------KKSKAEVDELGMGFCP
GD---------GAAAAAAASAN------------GGYAFLAEVPDS-----EEGESGWTD
TESDSDSEPETQHRGRG----------------------------KK----TVPMQKSPF
PYEID--------EILGVRDLRKVLALLQKSDDPFIQQVALLTLSNNANYSCNQ------
----------ETIRKLGGLPIIANMINKTDPHI------KE-KALMAMNNL-SENYENQG
RLQVYMNKVMDDIMASNLNSAVQVVGLKFLTNMTITNDYQHLLVNSIANF-FRLLSQGGG
K-IK-VEILKILSNFAENPDMLKKLLSTQ---VPSSFSSLYNSYVES----------EIL
INALTLFEIIYDNLRAEVYN-----------YREFNK--GSLFY-LCTASGVCVKKIRAL
A-NHHDLLVKVKVIKLVNKF----------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MTGTKN--KTRAQSA------
-IQAKAGEEREATGV------VRPV---------------------AKTWAKAKHKPGSL
-----TDAV---------------------------------------------------
------AEMKAV-------------SKNKVVAEMKEGALSEPKALGKAI-----------
-----GDF----------------------------SPKARNESTSSTCENGA-----G-
--------------------------------------VDAGN-HSSA------------
---------KNDKP--------EIGAQVSA----E-------------------------
------------ELEPVAGASCKPRSGAEE------------------------------
EEEENVIGNWFWEGDGTSFDP-NPKPVSRIVKPQP------------------VTIWPKS
PA-------VTPAVS-QASEASPPS----YIVLGLAEEISYSWPVA-------AACPCRN
TCSCSQPVPE------------------------------------------EVNGIKPF
ACPCKM------ECYVDPEEFEKLVSLLKSTTDPLVHKRAQIAMVITLNPP---------
-----------------------------------------------------SGDERQH
KIELHVKHMCKDTTSFPLNSPGQQSELKILGQLTMDFVHHYIVASDFSEL-FHLPSSGKY
K-AR-NLVLKVILNMPENPTAARDTINMK---ALAASKLIFNHKEAK----------TNL
VSGMAVFINIKEHIRKGSIVVVD----------HLSY--NTLM-GIFREVKGIIETM---
------------------------------------------------------------
-------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------GP-EREMSPA
VVRPKV--------------------------RTQA------------QVMPGARPKTES
------KAMAGARPKTESQTVAGARPKT----------------------------DCQA
MAGARPRT----------------------------ESQAMAGARPKTE------ARAVG
GARPKT--EAKAVPGSRPKDEA--------------Q--------------AWAQTEFV-
-----AEAMSQAEGMSQTHAVAWPLVGTES--GSVVKPMALSVDRELVNVDSETFPGSQ-
-VQTGIQPWFASG-EETN------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---MGSWCYPRPRAR-EEASNESGFWSADETSTMSSFWAGEEASIRSWPREEA---NTRS
RHRAKHQ-----P--NPRSRPRSKQDPYIDS-WSGSE-----------------------
-EESGNPFCLWAGENTSNLF----------------------------------------
---------------------RPRVRDEANIRSKLRTKREDF--FESESE------DEYY
KESWFLPGEEA---------SSR-----FRPRDKEEPHTVLKPR----------------
VQ----KDVNNSDKVKQEPRF-----EEEVIIGSWFWAEKEA------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------GM
EAG------ASAICESRPGAE-----EGAI------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------GGSLFWTEEKS
SLGA--------------------------------------------------------
-----------------------------------------------VAREEARPES---
------------------------------------------------------------
------------------------------------------------------------
-EEEAIFGSWFWDRDEACFDL-NPSPVYRANSRFRDSVEEEVNVSSRPQTWEEVTVEFKP
-GPC----HVVGFPSPSSFRISDEA-ASVFSEMFEGKPKNVELTPEG----E--EQESLL
QSDQ--PESEFPFQYDPSY--------------------RSVREIREHLRARESAEPETW
SCSCIQ-----CELKIGTAEFEELLLLMDKIRDPFIHEISKIAMGMRSASQFTR------
----------DFIRDSGVVSLIETLLNYPSSRV------RT-SFLENMIHM-APPYPNLN
MIETFVCQVCEETLAHSVGSPEQLLGLKMLRHLTSTTDYHTLVANYMSGF-LSLLTTGNA
R-TK-FHVLKMLLNLSGNAMVAKKLFSAK---ALSIFVALFNVEETN----------DNI
QIVIKMFQNISNIIKNGTMALID---------DDFSL--EPLI-SAFHEFEKLAKELQVQ
IDNQKDPEVGQQS-----------------------------------------------
-------------------------------------------

------------------------------------------------------------
--------------------------------------------MGRVQDVGWATAGLVI
WAGTCYCIYRLTKGRTQSVSGLARNGSRI-ETETMVG----EQNQTLATSEAMAGREAET
RIK--TEPESGEGGEPVAEVDFKVPVLVRPSDNCQ----AKTMLEEEIETQSE-------
TSSLVETVVMAEAVTLTEST--SQAKEVTMKEAVTQTDAEAEAVGKKEAVTQTK-AKAWA
MAGRAEVKKEAMTQTKAEAHTLDEKETEINRVTVTQSEVLAVTKE----VVKIGSMNETG
IVAEATMRSLEETLAVPRTQSEARLDATVATKENPNDLSVVVAGVDMKSYAQSQAVTIVK
NDDMAGAETDNQEDLK---------------------------NMSKAGSGVDMKASGQP
HTAASILAEAVPGAKNDAWDNANDICEAE--TDIRTCIIQPETVAKIEAEATSGAM-MDG
GEAAS--VKAMTDADVTD-TQPQTVTSDQTEAMPDAKVKGKGNASALAKAGAKANTKTNL
QTDALSDPGDKNRSDNNVMAKAETGIDMVSPT-QTEPVA--------------KDNANTT
SKEGAQA--------TAQSQGEALPNTKGKARGKAKAKCKAAAGTDTKTCAQPQAGTK--
AEALSDSKVDSKSDSNAVSKAGAKADQKACGQPQPVVNCQNEVLPGTKNKVKGNPNPMPK
TEAGTAPTSSAQT-----------------------------------------------
------------------------------------------------------------
------------NVVSSSQGETTPGAKNKAKGNRNSVPKAGAGPDT--------------
--------------------------TGSAQSQTVASSHSEALPGAKNKVKSNPN-VPKA
EAGVGACPQSV-------------------------------------------------
------------------------------------------------------------
--------------------------AASQGIALTGTKTKVKGNSNAVSKQDTGAGTM--
------------------------------------------------------------
----------------------------------------------------------GS
VHAKAVANSQGETLPGSKNKVKGNSNAVPKAE-----AGAGTTDCIQPQ------AEALL
GARNKARGNSSSVPKAESGASTILA-----LASSQAEALLGARNKVRGS--SNATPKAEA
GVGSRGCAQSQAVVSSQNETLLGARNKIRSNA--GTKSGARTGTRSSAQPQAVVSSQNET
LLGARDKG----------------------------------------LSSSQVEATADN
RIYAKPM--VAAVPTSEMVTVA------GTQPNIHDYYWNGIGVEDWIAAERWIKFRFQT
IDGDWENSVSWTEDDSGASIGPWSGA-NDK--AGVVSSWAVAC----DETSIKSWTGART
DNEVALGSWVGAG-DQASGALWAGAQTSEGTWVGD------------KATAASWTGAENQ
ITAGSWVVSGNQAIAGPWAVSQVSDGSWPTVQASGVSWVVDQATG-TWTV--------AE
NQTGAVSWAGA--------------------------GNIVSIGYWTGAVDQTNA-VSWT
GT------------SDQVGGEAKPRFEDQASEKGSWTV--VQTSGESRLGSEDQSSGRSW
TEAVDQTSAASRLGTVDPAAGTSWVGTGDQTVGGSTSGSAEQSGSGSWAGTRNL------
------AGERSWTGTGDQPDGATKPSFENQTSDEG-SWTGTIGQPSGGSKSVSEDQSAAR
SWTDSGDQLSGGFLVGPLDQASSESQPVS----GEMAASG-----VDQSSGGGCWT-GSG
DQSGGESRLGPRDQSNGESWPGTGDQTSG------------WY-------------CTYT
G---TQTIGGGSWVGPGAQDVGGSKPVHMNQTSGGAWLGTGTQVSAVSWTGD----QVGG
CPKPGFEDQTIGGGFWAGAGDQTTGGSRPAVSED-QSSAGVSWGGTGAHVI---------
------------------------------------GGS----TDQSSGGSWPGMG---N
QVSGGSWIGPV--DQ-TSGCTKSGFEDQ-SCGGGSWAGAGDQTSGESWPGSRASNE----
---ASGG-----S--RL-----------------DSQ-----------------------
--------------------------DQAGGGSWIRSEDQASGRFLVSAEVEANEGFWFG
PGSEAFIGSWCWTEE-ATILPVAEMKEEASTESTSGTREETIVSSGVGDE------KKTS
TESWTRSEETA--------FTGTCAGSETDTVAGAQAEVEPESKARPEAEAEAEAE--AE
VEAE------VRVGTR--ADA-----GAAVATD--------SEARAETGARVEAG-----
------------------------------------------------------------
-------------------------------------------------------AAAEA
GMGFWPWNG-DGTTKGSRLGAEAEAGVGGG---------------------------AEA
ETETENSMGFWFWNGD--AAT------DE------SKLGTEAKAE--AEIGTGTGTE--P
ETGTGV--------GGGAEAV-----AETSMGFWFWDGD--GGT--KGSRLGTEA-----
--EAGVGAGAQAGA--E----------AVAETS-MEFWSWDGDQATKGSRLGAEAEPG--
------------------------A--------------------------------G--
------------------------------------------------------------
---------------V-----------------------------VAEAGAETSMGFWFW
NQDS------------------------TTKGSGLGAEAGNGL-----------------
---GSWTLSTNVNDDEDEE-EDELSRESSP-GI-EEIS----------------------
-LRTLFGAESEDSNDLRST--------NEKD--VNSESGTGDKADDSKGQFDA-------
-ANGVDIRSWFYTGNESRCQN-ESSSQVKAKKSME-S----------RGIYPSM-VPGAG
MGVW----DGAIVCSESK--LL------------HK----TSFPGED----G-----FR-
RQ-V-----------------------------------NP------------GVKVHSC
NCRCKR------TVNLDPHDLEKLICMIEMTEDPSVHEIATNALYNSADYPYPQ------
----------EIDRNIGGISVIQSLLNNPYPNV------RQ-KALNALNNL-SVAAENHR
KVKTYLSQVCEDTVTYPLNSNVQVAGLRLIRHLTITSEYQHMVTNYISEF-LRLLALGSG
E-TK-DHVLGMLVNFSKNPSMTRDLLIAN---APTALINIFSKKETK----------ENI
LNALLLFENINHHFKKRGKTYPQ--------DR-FSK--TSLY-FLFQRPKACAKKLRAL
AADCSDPEVKEKVEVLINKL----------------------------------------
-------------------------------------------

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---------------------------------MSRVRDAGCVAAG----------IVIG
ASAWYCVYKYA--GGSSQ-TKKRMP----KPKSRA--VASNGARARAGIKAGFTIDLGPG
VGPPTPVHIEIENK-VQDEISALEASGTVTVVPTA------STAEAQSGSENQAQEAVGQ
--VK-PKA-KSGVGAAESSSITLLVGHAEAP------------TAAEGPTVAGDPKLAEP
PNT----------------A--------EVPGAPVITPGATLPIEAAVPT----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------EAVEA----------------------------
------------------------------------------------------------
-----------SIPAVP------------------------------S------GAAV-P
TGAAA-----------TSGAA-----------------E-AS------------------
----------------------GTSGSPR-------------------------------
-----------AAS-----SSRRTTPGAHTGAIPKTGSASATGA---VPKSGA-------
-----------KGGNKSRNGG-K----SKN--------------KRNKVEVDELGLGFRP
GD---------GAAAAAAASAN------------GGHAFLAEIPDS-----EEGESGWTD
TES-SDSEPETQQRGRGG---------------------------RR----PVGMQKRSF
PYDID--------EIQSDRDLRRVLSWLRKSDDPFIQQVGLLTLSHNANYSCSE------
----------ETIGKLGGLPIIANMITXXXXXX------XX-XXXXXXXXX-XXXXXXXX
XXXXXXXXXMDDIMASNLNSAVQVVGLKFLTNMTITNDYQHLLVNSIANF-FRLLSQGGG
K-IK-VEILKILSNFAENPDMLKKLLSTQ---VPASFSSLYNSYVES----------EIL
INALTLFEIIYDNLRAEVFN-----------YREFNK--GSLFY-LCTTSGICVKKIRAL
A-DHHDLLVKVKVIKLVDKF----------------------------------------
-------------------------------------------

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-----------------------------------------------MGRARE--MGWMA
AGLM----IGAGACYCMYKLTM------------GR--GARNDLED------EEEDDCDD
EQDLEEEEAKIWFDFTTMARPWSKDGDWDEPGAPGGTEARHSGGGKANRA--HPIKQRPF
PYEHK--------NTWGAQTFKSFSCALDRGMCASIQGKKMFTKPTNAGFPPSH------
----------NVSRHWASISVVANGIPTPQTTV------RE-KALCVPENP-NTSIGNQG
QTEMSIHEVCREMVLHCCKSFLQQAGLNLLISMMVINN---MLAKSVSDLKFPLISEGSG
C-AK-VQGLEALLGLSEKPVLAGEVLAAQ---MLFSFMLPFMRGGNR----------EML
AEALSP------------------------------------------------------
------------------------------------------------------------
-------------------------------------------

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-----------------------------------------------MGRARE--MGWMA
AGLM----IGAGACYCMYKLTM------------GR--SEGNELED------EEEDEWND
EQDLDEEEADNWFDFASMARPWSEDGDWDEPGAPGGTEDRRSGGGKANRA--HPIKQRPF
PYEHK--------NIWGEQSFKSFSWILDLTKCVSTQRKKMFTESTNAGFPLSH------
----------NVSKHLASLSGVGNTSPTPQPTV------RE-KALFVPENP-DSSLENQG
QIKMSIDGVCRETALCCCKSFLQQAGLSLLISMTVXNN---MLAKCVSDLKFPLLSEGSG
C-AE-VRGLEELMSLSEKPVLAEEALAAQ---MLXSFMCLFTRSGSR----------EML
VEGISP------------------------------------------------------
------------------------------------------------------------
-------------------------------------------

------------------------------------------------------------
--------------------------------------------MGRVQDVGWATAGLVI
WAGTCYCIYRLTKGRTQSVSGHARNGSRI-ETETVVG----EQNQTLATSEAMAGREAET
RVK--TEPETGEGGEPVAEVDSKVPVLVRSSGNCQ----AKTMLEEEIETQSE-------
TSSLVETMVMTEAVTLTEST--SQAKEVTMKEAVTQTDAEAEAVGKKEAVTQTK-AKAWA
MAGRAEVKKEAMTQTKAEARTLAEKETEINRVTVTQSEVLAVTKE----VVKIGTMNETG
VVAEAMIRPLEETVSVTRTQSEARLDAAVDTKENLNDMSVVVTGVDTKSCAQSQAVAIIQ
NDDMAGAEAD-KEDLK---------------------------NMSKAGSGIDMKVPGQP
HIAANNLAEAVPGAKNDAWDNAKDICEAE--ADIRTCLIQSETVAKIETEATSSAT-MDG
GKDAN--AKAMTDVNVTD-TQPQAVTSDQTEAMPDAKVKGKGNASAMAKAGAKANTKTSS
QTDALPDAGDKNRSDNNVTAKAETGIDMVSCT-QTEPVA--------------KDNANTT
SKEGAQA--------TGQSQGEALPNTKGKARGKAKAKCKAAAGTDTKTCAQPQAGTKTQ
AEALSDSKVDSKSDSNGVSKAGAKADQKASGQPQPVANCQNEALPGTKNKVKGNPNPTPK
TEAGTATTSSAQT-----------------------------------------------
------------------------------------------------------------
------------NVT-SSQGETTPGAKNKAKGNRNSVPKAGAGPDT--------------
--------------------------TGSAQSQTVANSHSEALPGAKNKVKSNSNVVPKA
EAGVGACPQSV-------------------------------------------------
------------------------------------------------------------
--------------------------PASQGTALTGTKTKVKGNSSAVSKPDAGAGTM--
------------------------------------------------------------
----------------------------------------------------------GS
AHAKTAANSQGETLPGSKNKVKGNSNAVPKAE-----AGAGTTEPNQPQ------AEALL
GARNKVKGNSNSVPKAESGASTILA-----LASSQAEALLGARNKVRGS--SNAAPKAEA
GVGARGSAQSQAVVSSQNEALLGARNKIRSNA--GTKSGARTGTRGSAQPQAVVSSQNEA
LLGARDKG----------------------------------------LSSSQVEATGDN
RVYAKPM--VGAVPASEMVTVA------GAQPNVHDYYWNGIGVEDWIAAERWIKFRFQT
IDGDWENSVSWTEDESGATIGPWTGAANDK--AGLVSSWAVAC----DESSIKSWTGARP
ENEVALGSWVSAG-DQATGAIWAGAQTTDGTWVAD------------KASAGSWTGAENQ
ISAGSWVVSGNQAIAGPWAVSQVTDGSWPAVQASGVSWVVDQATG-TWTV--------AE
NQTGAVSWAGA--------------------------GNIVSIGYWTGAVDQTNA-VSWT
GT------------TDQVGVEVKPRFEDQASEKGSWVVAGVQTSGETRLGSEDQSSGRSW
TETVDQANAASRLGTVDQAGGTSWAGTGDQVGGVSTSGSADQSSSGSWAGTRNL------
------AGERSWTGTGDQSDGAAKPGFENQTSDEG-SWAGTIGQPSGGSKSVSEAQSAGR
SWADSADQLSGGFLVGPLDQANGESQPVS----GELAASG-----VDQTSGGGCWT-GSG
DQSGGESRLGPRDQSNGESWPGTGDQTGG------------WY-------------CTYT
G---TQTIGGGPWVGVSGQDVGGPKPVHMNQATGGAWLGTGTQVSAVSWTGD----QVGG
CSKPGFEDQAIGGGFWAGAGDQTTGGSRPAVSED-QSSGGVSWGGAGGHVI---------
------------------------------------GGSR---TDQSSGTSWPGMG---S
QVSGGSWIGSV--DQ-TSGCTKSGFEDQ-TCAGGSWVGTGEQTSGDSWPGSRASNE----
---ASGG-----S--RL-----------------DPQ-----------------------
--------------------------DQASGGSWIRSEDQASGRFLVSAEVEANEGFWFG
PGSEAFIGSWCWTEE-ATILPVAGMKDEASTESTSGTREETSISSGLGDE------KKTS
PESWTRSEEAA--------LTGTCDGGEAKTVAGAEAEVDPESKTRAEAKAEAEAE--TK
VEAE------VRVETR--AEA-----GAAATTA--------SEAGAEAGARVEAG-----
------------------------------------------------------------
-------------------------------------------------------AGAEA
GMGFWPWNG-DDTTKGSRLGAEAEAGAGGG---------------------------AEA
GAETENSMGFWFWNGD--AAT------KG------SKLGTEAEAE--TGIGTGTGAG--T
G--TGTGTGTGVGAGVEVQAV-----ADTSMGFWFWDGA--GAT--KGSRLGTEA-----
--EAGVGAGAQAGA--E----------AVGGTS-MEFWSWDGDEATKGSRLGAEAEPG--
------------------------T--------------------------------G--
------------------------------------------------------------
---------------V-----------------------------VAEPGAETSMGFWFW
NEDS------------------------TTKGSGLGTEVGAGL-----------------
---GSWTFSTNVNDGEEEEEEDELSRESSP-GI-EEIS----------------------
-LRTLFGAESEDSNDLRST--------NEKD--VSSEPGTGDKADDTKDQFDA-------
-ANGVDIRSWFYTGNENKCED-ESSSQVKVKKSTE-S----------RGIYPSM-VPGAG
MGVW----DGTIVCSESK--LL------------HK----TSFPGED----G-----FR-
RQ-V-----------------------------------ST------------GVKVHSC
NCRCKR------TVNLDPHDLEKLICMIEMTEDPSVHEIATNALYNSADYPYPQ------
----------EIDRNIGGISVIQSLLSNPYPNV------RQ-KALNALNNI-SVAAENHR
TVKTYLSQVCEDTVTYPLNSNVQVAGLRLIKHLTITSEYQHMVTNYISEF-LRLLALGSG
E-TK-DHVLGMLVNFSKNPSMTRDLLIAN---APTALINIFSKKETK----------ENI
LNALLLFENINRHFKKRGKTYPQ--------DR-FSK--TSLY-FLFQRPKACAKKLRAL
AADCSDPEVKERVEVLINKL----------------------------------------
-------------------------------------------

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-------------MICRLDSAVQMAGLRLLTNMTVTNHYQHLLSYSFPDF-FALLFLGNH
F-TK-IQIMKLIINFTENPAMTRKLVSCK---VPSELISLFNKEWDR----------EIL
LNILTLFENINDNIKTEGLASS---------RKEFSR--SSLFF-LFKESGVCVKKIRAL
A-SHHDLVVKVKVLKVLTKL----------------------------------------
-------------------------------------------

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-------MTGAEIESGAQVKPEKKPGEEVV--------G-----------GAEIENDVPL
VVRPKV--------------------------RTQAQIMPGARPKNKSKVMPGASTKV--
------------------------------------------------------------
------------------------------------------------E------TSAVG
GARPKS--KAKAIPVSRFKEEA--------------Q--------------MWAQPRFG-
-----AERLSKTERNSQTNIIASPLVSTDS--VLVAKTKYLSEDRELVNTDTESFPRRKA
HYQAGFQPSFRSK-EETN------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---MGSWCCPRPTSK-QEASPNSDFKWVDKS-VSSLFWSGDEVTAKFHPGNRVKD-SNRS
MHMANQE-----A--NTMSRSQTNQELYIAS-SSGSE-----------------------
-DESVKTPWFWARDKTNTWS--GPREDP-NSRSRFRSKKEVYV------------ESSSG
SEHEDHLESWFGAGKEAKFRSKMRAGKEANNRARHRAKREACIDFMPGSI------DVIK
KESCFWPEENA---------NTF-----SRPMIKKEARARAMTK----------------
EE----AKTKARARAKQEARS-----EEEALIGTWFWATDESSMADEASIESSLQVEDES
IIGSWFWTEEEASMGTGASSKS-RPRTDGERIGDSLFGAR-EKTSMKTGAEATSESILAA
DDE-QVIIGSWFWAGEE-VN---------------------------------QEAEEET
IFGSWFWVIDAAS-VESGVGVSCE-------------------------------SRTR-
-SEEEEVIGPWFWSGEQVDIEAGIGEE----------ARPGAEEETIFGSWFWAENQTYM
DCR------AETSCDTMQGAE----EEEPIIGSWFWTRVEACVEGDVNSKSSLEDKEE-A
MI-PCFGAKEEVSMKHGTGVRCRFMAGAEETNNKSCFWAEKEPCMYPAGGGSWKSRPEEE
-----EDIVNSWFWSRKYTKPEAIIG------------------------SWLWATEESN
I-DGTGEKAKLLTEEETIINSWFWKED-EAISEATDREESRPEAEEGDIIGSWFWAGEED
RLEPAAETREEDRLAAEKE-GIVGSWFGAREETIRREAGSCSKSSPKAEEEEVIIGSWFW
EEEASPEAVAGVGFESKPGTEEE----EITVGSWFWPEEEASIQAGSQAVEEMESETEEE
TIFGSWFWDGKE-----VSEEAGPCCVSKPEDD-EEMI----------------------
-VESWFWSRDKAIKETGTVATCESKPENEEGAIVGSWFEAEDEVDNRTDNGSNCGSRTLA
DEDEAIVGSWFWAGDEAHFES-NPSPVFRAICRSTCSVEQEPDPSRRPQSWEEVTVQFKP
-GPW----GRVGFPSISPFRFPKEA-ASLFCEMFGGKPRNMVLSPEG----E--DQESLL
QPDQ--PSPEFPFQYDPSY--------------------RSVQEIREHLRAKESTEPESS
SCNCIQ-----CELKIGSEEFEELLLLMEKIRDPFIHEISKIAMGMRSASQFTR------
----------DFIRDSGVVSLIETLLNYPSSRV------RT-SFLENMIRM-APPYPNLN
IIQTYICKVCEETLAYSVDSPEQLSGIRMIRHLTTTTDYHTLVANYMSGF-LSLLATGNA
K-TR-FHVLKMLLNLSENLFMTKELLSAE---AVSEFIGLFNREETN----------DNI
QIVLAIFENIGNNIKKET-VFS---------DDDFNI--EPLI-SAFHKVEKFAKELQGK
TDNQNDPEGDQEN-----------------------------------------------
-------------------------------------------

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-----------------------------------------------MGRARE--VGWMA
AGLM----IGAGACYCVYKLTI------------GR--DDSEKLEE------EEEEEWDD
DQELDEEEPDIWFDFETMARPWSEDGDWTEPGAPGGTEDRPSGGGKANRA--HPIKQRPF
PYEHK--------NTWSAQNCKNGSCVLDLSKCLFIQGKLLFAEPKDAGFPFSQ------
----------GINSHLASLSMVRNTSPTPDPTV------R--EALCAMDNL-NASIESEG
QIKMYINEVCQETVSRCCNSFLQQAGLNLLISMTVINN---MLAKSLSDLKFPLISEGSG
C-AK-VQVLKPLMGLSEKPVLAGELVGAQ---MLFSFMSLFIRKGNR----------EIL
LETPAP------------------------------------------------------
------------------------------------------------------------
-------------------------------------------

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------------------------------------------------------------
-------MTGAEIEPAAQAKPEKKAGEGVG--------G-----------GAERENEIPL
VVTPKV--------------------------RTQAQVIPGVRPKSDAMVVGGARPRA--
------------------------------------------------------------
------------------------------------------------E------PVGVG
AMHPKP--EAKAIPGSRPSDKA--------------H--------------SWAQTEFD-
-----SKAMLKTGGVSQTNTIAWQLVSTES--GSAAKSKTLSMDRELISVDTESFSGTKV
KYQSGKQPLFGSE-EKTN------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---VGSWWCPRPTSK-QEISQKYDFSWADRSSMSSWFWSGEEVNTKFHPRGRVKA-SSRS
RRIAREE---------AMFRPTINQEYYILS-SSGSE-----------------------
-DESFKTSGLWAREKTNTWS--RPKEEI-NNRSRFRSKKEIS-------------ESSSG
SGCEDNVKSWFWAKEEAKSRSKPRIRKGANVRARHRAKQEASIDFVSGSV------DVVK
KESWFWPREKA---------DNL-----SKPKSKKEARTRITAK----------------
EK----VKTKARARARKEAKS-----EEEFLLGNWFWATEESSVVGGSSVKYSSQGEDES
VVGSWFWTEEEASMRTDASSKS-RPRAEEESAGNSMLGSG-ENISMETGSEATFKSVVAY
DKG-KVIAGSCFWASEE-IN---------------------------------LEAEEET
IFGPWFWVSDETS-VEADVRASCA-------------------------------SRPR-
-SEEEEVIGPWFWDRK-VDTEAEFGEE----------ASPEDEEETIFGEWFWAGNQAQI
DSG------VKISCDTMPGAE-----EEPIIGSWFWDGVEAYIGTEVSNKSSLKDKEE-V
ILSSWFGTTEEVSMQYGAGARCKFMAWAEEMNNESCFLGEDDPCMYTANGGSWKLRPEEE
-----QDSVDSSFLSRKYTSPEIIIG------------------------PWLWATEEVT
IDDGTGEEAKALMEEETVITSWFWKGD-KTSREATDREESKPDAEEQDIIDSWFWAGEED
RLKTAAEAREKDRLATE---------------------------NPEAKEEEATVGSWFW
AEEEA-NLEAGASFESMPVTEEE----EIIVGSWFWAEEEDSTEFGPQAVEESRSNTEEE
IIFGSWFYAAKE-----VSAEAEKCCASQPEDD--EII----------------------
-VESWFWSEEKDINETGTVVTCESRLENKEGTVVGSWFGAKDEANNRNGYGTNYETRRVA
EEDEAIVGSWFWAGDESHFES-NPRPVFRAIPRSKCSFEQEPDASHRPQTWEEVTIQFKP
-GPW----GRVGFPSPIPFRFPKEA-ACLFSEMFGEKPKHMELNTGG----E--EQESLL
Q-----PEPEFLFQYDPSY--------------------RSVREIREHLRTRESAEPDSW
SCSCIQ-----CEVKIGSEEFEELLLLMDKIRDPFIHEIFKITMGMRSASQFTR------
----------DFIRDSGVVSLIETLLNYPSSRV------RT-SFLENMIRL-APPYPNLN
MIQTYVCQVCEETLAYSLDSPEQLSGIRMVRHLTTTTDYHTLVAKYMSGF-LSLLAMGNT
K-TR-FHVLKMLMNLSENPVMTKELLSAE---AMSEFMSFFKRKETN----------DNI
QVVLTMFENIGNNIKKESVLFP---------DDDFSL--EPLI-SAFHEVEEFAKELQSK
TDGQKDP-----------------------------------------------------
-------------------------------------------

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-------MTGAEIEPSVQAKPEKKAGEEV--------IA-----------GAERENDVPL
VVRPKV--------------------------RTQ--ATTGARPKTETKSVPGARPKTDA
------QAMSGA------------RPKT----------------------------EAQV
MGGARPKT----------------------------EAQGMAGARPKTD------ARAVG
GARPKT--DAKAIPGTRPKDEA--------------Q--------------AWSQSEFG-
-----TEAVSQAEGVSQTNAVAWPMATAES--GSVNKSKGLSMDRELVDVDAETFPGTQ-
-GQKGIQPWFRPG-EETN------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---MGSWCYSRPRAR-EEASNESGFWSADETSTVSSFWAGEETSIRSWPREES---NTRS
RHRAKHQ-----T--NPRSRPRSKQEAYVDS-WSGSE-----------------------
-DEAGNLFSFWAGENTSNLF----------------------------------------
---------------------RPRVREEANIRSKLRTNREDC--FESESE------DEFY
KQSWVLPGEEA---------NSR-----FRCRDKEDPNTALKPR----------------
AQ----KDV-DGDRVKQEPRF-----EEEVIVGSWFWAEKEA------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------SL
EGG------ASAICESEPGTE-----EGAI------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------GGSTYWAEEKS
GLGA--------------------------------------------------------
-----------------------------------------------VAREEAKPES---
------------------------------------------------------------
------------------------------------------------------------
-EEEAIFGSWFWDRDEACFDL-NPCPVYKVSDRFRDAA-EELNASSRPQTWEEVTVEFKP
-GLF----HRVGFRSTSPFRIPEEAS-----EMLEAKPKNMELSPEG----E--EQESLL
QPNQ--PSPEFTFQYDPSY--------------------RSVREIREHLRARESAESEGW
SCSCIQ-----CELKIGSEEFEELLLLMDKIRDPFIHEISKIAMGMRSASQFTR------
----------DFIRDSGVVSLIETLLNYPSSRV------RT-SFLENMIHM-APPYPNLN
MIETFICQVCEETLAHSVDSLEQLTGIRMLRHLTMTIDYHTLIANYMSGF-LSLLTTANA
R-TK-FHILKMLLNLSENPAVAKKLFSAK---ALSIFVGLFNIEETN----------DNI
QIVIKMFQNISNIIKSGKMSLID---------DDFSL--EPLI-SAFREFEELAKQLQAQ
IDNQNDPEVGQQS-----------------------------------------------
-------------------------------------------

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-----------------------------------------------MGRARE--VGWMA
AGLM----IGAGACYCVYKLTI------------GR--DDSEKLEE------EGEEEWDD
DQELDEEEPDIWFDFETMARPWTEDGDWTEPGAPGGTEDRPSGGGKANRA--HPIKQRPF
PYEHK--------NTWSAQNFKNGSCVLDLSKCLFIQGKLLFAEPKDAGFPFSQ------
----------DISSHLASLSMARNTSPTPDPTV------R--EALCAPDNL-NASIESQG
QIKMYINEVCRETVSRCCNSFLQQAGLNLLISMTVINN---MLAKSVSDLKFPLISEGSG
C-AK-VQVLKLLMGLSEKPVLAGELVGAQ---MLFSFMSLFIRNGNR----------EIL
LETPAP------------------------------------------------------
------------------------------------------------------------
-------------------------------------------

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--MLSTL--------LLTPLSA--------------D--------LQYTVHFRQK-----
-EGRNRRTCA---------------------------------AVPLYFQLQLSLPAVA-
EDSDPAVYSLPRAEQTGSGSE-IR-----TSCTMGRTRDAGCVAAG----------VVIG
AGACYCVYRLT--WGRDE-SGKIWD----DDDEECSD--RA-------------------
----------------------------ETGVGNE------KGDEANAGAGAGATHKA--
---------------------------DLVV------------KSEVGLGVKSGPGVKAE
A-L----------------S--------TQRGGGLE---AKA------------------
-----------------KALFNTL------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------REQASTKAGRGNRVGASS--------------------------
---------------------------------------------GTRTLAPSLPCPGGR
GG---------GCHPTRNGARA---------------------------------GGRAS
GKPKGKTKAKGPKAPA-T---------------------------AV----PVRRTKFNF
PYKID--------DILGATDLQKVLNILERTNDPFIQEVALVTLGNNAAYSFNQ------
----------NAIRELGGVPIIAKLIKTKDPII------RE-KTYNALNNL-SVNAENQG
KIKMYISQVCDDTMICRLDSAVQMAGLRLLTNMTVTNHYQHLLSYSFPDF-FALLFLGNH
F-TK-IQIMKLIINFTENPAMTRELLSCK---VPSELISLFNKEWDR----------EIL
LNILTIFENINDNIKNEGFASS---------RKEFSR--SSLFF-LFKESGVCVKKIKAL
A-NHNDMVVKVKVLKVLTKL----------------------------------------
-------------------------------------------

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---------------------------------------MPGNKN--KMRAQAKTEKK-T
GVQAKAGTEREAAGA------GKPV---------------------AKTRAKAKAKAGSK
-----AVPL---------------------------------------------------
------AEVKTM-------------SKNRAVAEIKEGAMSEPKTPAKAV-----------
-----ADC----------------------------SPRTKGDTSRSTGKNEAGTDSCFW
AGKE------------------------AGINTWVCNGEEAGN-RPRA------------
---------KDEKKT------TVR-ARVSA----K-------------------------
------------ESEAVSGPSCKPGSGAEE------------------------------
EEEETVIGNWFWEGDDTSFDP-NPKPVCRIIRPQP---VDEINEKNRPKDWSEVTIWPKA
PAVTP---AVLGFRSQAPSETKPSS----YVVLASAEENTRSLPA-------TTACSSRG
ARSNSQPVPEYPFGADPCI--------------------QTLDEIRRQIKIREVNGIKPF
ACPCKM------ECYMNSEEFEKLVSILKSTTDPLIHKIAQIAMGIHKVHPFAQ------
----------EFINEVGVVTLIESLLSFPSPDM-------RKKTVITL-NP-PSGGERQH
KVELHVKHMCKETVSFPLNSPGQQSGLKILGQLTTESVHHYIVANYFSEL-FNLLSQGNR
K-TR-NLVLKLLLNMSENPSAARDMINMK---ALTALKLIFNQNEAK----------ANL
VTAVAIFINIKEHIRKGSIVVVD----------HLSY--NTLT-DIFREVKGIIEAM---
------------------------------------------------------------
-------------------------------------------

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---------------------------------MGGARDAGWVAAG----------LVLG
AGACYCIYRLT--RGPRR-GGR-----------KLRP--SR-------------------
------------------------------------------SAE---------------
------------------------------------------------------------
------------------------------------------------------------
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---------------------------------------------------------DLT
DSSYD--------EVLNAEQLGKLLYLLESTDDPIIVEKALVTLGNNAAFSTNQ------
----------AIIRELGGIPIIGNKINSLNHSI------KE-KALNALNNL-SVNVENQV
KVKVYVRQVCEDVFADPLNSAVQLAGLRLLTNMTVTNDYQHLLSSYITGL-LHLSLIGNG
S-TK-VQVLKLLVNLSENPAMTDGLLRAQ---VDSTFLSLFDGQIAN----------EIL
LRALTLFQNINNCLR-EGCPAG---------QPPFDK--GSLFSLLYGE--DCAQKVRAL
V-CHHDVAVKEKALAIMPKF----------------------------------------
-------------------------------------------

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---------------------------------------MAGTKN--KTRAQAKTEKK-A
AIQAKAGAEREATGV------VRPV---------------------AKTRAKAKAKTGSK
-----TDAV---------------------------------------------------
------AEMKAV-------------SKNKVVAETKEGALSEPKTLGKAM-----------
-----VDF----------------------------TPKAGNESTSSTCKNEAGTDAWFW
AGEE------------------------ATINSWFWNGEEAGN-SFST------------
---------KNDKP--------EIGAQVCA----E-------------------------
------------ELEPAAGADCKPRSGAEE------------------------------
EEEENVIGNWFWEGDDTSFDP-NPKPVSRIVKPQP---VYEINEKNRPKDWSEVTIWPNA
PAVTP---AVLGFRSQAPSETSPPS----YIVLASAEENACSLPVA------TACRPSRN
TRSCSQPIPECRFDSDPCI--------------------QTIDEIRRQIRIREVDGIKPF
ACPCKM------ECYMDSEEFEKLVSLLKSTTDPLIHKIARIAMGVHNVHPFAQ------
----------EFINEVGVVTLIESLLSFPSPEM-------RKKTVITL-NP-PSGDERQR
KIELHVKHMCKETMSFPLNSPGQQSGLKILGQLTTDFVHHYIVANYFSEL-FHLLSSGNC
K-TR-NLVLKLLLNMSENPTAARDMINMK---ALAALKLIFNQKEAK----------ANL
VSGVAIFINIKEHIRKGSIVVVD----------HLSY--NTLM-AIFREVKEIIETM---
------------------------------------------------------------
-------------------------------------------

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---------------------------------MGYARKVGWVTAG----------LVIG
AGACYCIYRLT--RGRKQNKEK-MA----EGGAGDMD--DTG----------------DC
---------------------------------------------------------SGG
--RCNDWSEDD-------------------------------------------------
DDS----------------N--------D-------------------------------
------------------------------------------------------------
-NKGVVWYPPWAR-----------------------------------------------
------------------------------------IG----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------T--------------------------------
-----------EAGTRARARA---------------------------------------
------------------------------------------------------------
-------------RARAT---------------------------RA----RRAVQKRAS
PNSDD--------TILSPLELQKVLCLVEMSEKPYILEAALIALGNNAAYAFNR------
----------DIIRDLGGLTIVAKILNTRDPIV------KE-KALIVLNNL-SVNAENQR
RLKIYMNQVCDDTITSRLNSSVQLAGLRLLTNMTVTNEHQHMLANSISDF-FRLFSAGNE
E-TK-LQVLKLLLNLAENPAMARELLRAQ---VPSSLGSLFNKKENK----------DII
LKLLTIFENINDNFKWEENEPT---------QNHFSE--GSLFF-FLKEFQVCADKVLGM
E-SHHDFLVKVKVGKFMTKLAEHMFPKSQE------------------------------
-------------------------------------------

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---------------------------------------MTGTKN--KTRAQAKTEKK-P
VTQAKAGAEREATGV------VRPV---------------------AKTRAKAKAKTGSK
-----TDAV---------------------------------------------------
------AEMKAV-------------SKNKVVAEVKEGALSEPKTLGRAM-----------
-----GDF----------------------------SSKAGNESTSSTCKNEAGIDAWFW
AGEE------------------------ATINSWFWNGEEAGN-SSST------------
---------KNDKP--------EIGAQVCA----E-------------------------
------------ELEPAAGADCKPRSGAEE------------------------------
EEEENVIGNWFWEGDDTSFDP-NPKPVSRIVKPQP---LYEINEKNRPKDWSEVTIWPNA
PAVTP---AVLGFRSQAPSEASPPS----YIVLASAEENACSLPGA------TACRPSRN
TRSCSQPIPECRFDSDPCI--------------------QTIDEIRRQIRIREVNGIKPF
ACPCKM------ECYMDSEEFEKLVSLLKSTTDPLIHKIARIAMGVHNVHPFAQ------
----------EFINEVGVVTLIESLLSFPSPEM-------RKKTVITL-NP-PSGDERQR
KIELHVKHMCKETVSFPLNSPGQQSGLKILGQLTTDFVHHYIVANYFSEL-FHLLSSGNC
K-TR-NLVLKLLLNMSENPTAARDMINMK---ALAALKLIFNQKEAK----------ANL
VSGVAIFINIKEHIRKGSIVVVD----------HLSY--NTLM-AIFREVKGIIETM---
------------------------------------------------------------
-------------------------------------------

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----------------------KA-------------------------------KAGFE
-----TDAV---------------------------------------------------
------AERKGV-------------SEAKVVTEMKARALSEPTALVKGV-----------
-----AKA----------------------------MPRSWARSAGATHKDETDTDAWFW
AGEE------------------------ASIGSWFWNGEEAGGDQTNA------------
---------KDEGE-------TDIGASINT----EEL-----------------------
------------GIEAATGASWKPRQ-V--------------------------------
-----VIGKWFWGGDKISFDP-NPRPVYRIVKPRV---TCEIDERNRPKDWSEVTIWPNA
PAEIP---ALLASRYQVPSRTRPLS----YTAQSSGEKNTGSLPAA-------EAGLHEG
TSVCLQSIDAYPFDSETCT--------------------QAIEKIRGQIRIRELNGIRPF
PCPCKM------ECRLNSEDFEKLVSLLKSNADPVIHKIAQIAMGIIKVHPLAQ------
----------ELINEMGVLTVIESLLDFQFPDM-------TRKAEITL-NP-ISVEERQR
RNIIHVVHMCKETVSFPLNSPGQRSGLKELGQLSADRDHHFIVAAYLPEL-SRMLSLGNH
K-TR-NLVLKVLLNMSENPIAARDMMNIE---VLSALKLIFHQKEAK----------ANL
VTAVAIFVNIKEHIRRGSIVVVN----------PVSY--NELK-AVFREVKTIIEKL---
------------------------------------------------------------
-------------------------------------------

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-----------------------------------------------MGRARE--VGWMA
AGLM----IGAGACYCVYKLTI------------GR--DDSEKLEE------EEEEEWDD
DQELDEEEPDIWFDIETMARPWSEDGDWTEPGAPGGTEDRPSGGGKANRA--HPIKQRPF
PYEHK--------NTWSAQNCKNGSCVLDLSKCLFIQGKLLFAEPKDAGFPFSQ------
----------DISSHLASLSMVRNTGPTPDPTV------R--EALCATDNL-NASIESEG
QIKMYINEVCQETVSHCCNSFLQQAGLNLLISMTVINN---MLAKSVSDLKFPLISEGSG
C-AK-VQGLKPLMGLSEKPVLAGELVGAQ---MLFSFMSLFIRKGNR----------EIL
LETPAP------------------------------------------------------
------------------------------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
-------------------------HIHFYIELYNCALIMSGGRN--GRRNKARRGKK-A
ALKAE--AEKAAAAA------ATP---------------------AAKSHGKSSAKAVAQ
-----ADA-K--------------------------------------------------
------AEMKAG-------------SKNRLVTEKKKGTKSDKGSKVEEEATK---KPQLC
SV---TEP----------------------------RAESKDKSGKATCKEKSGIDAWLW
GGED------------------------SSVGPWLWSGEEAGN-RSGV------------
---------KNGGKT------KDIGAQYCA----D-------------------------
------------KSEALGATGYKVKAGGDD------------------------------
EEEENVIGSWFWDGDETSFDP-NPKPVSRIIKPQP---IDEINEKNRPKDWSEVTIWPKA
PAVTP---AVLGFRSQTASETRPPS----YIVLASADESRHSVPEG--AAAAAAACPPRS
TSTCSQSIPEYPFGSEPCI--------------------QTIEEIRRQIRIREMNGIKPF
ACPCKM------ECYMDSEEFEKLVTLLKSTTDPLIHKIAQIAMGIINVHPFAQ------
----------EFINDVGVVTLIESLLSFPSSEM-------RKKAVLTL-NP-PSGDERER
KVELHVKHMCKETMSFPLNSPGQQSGLKILGQLTTNSNHHHIVANYFTEL-FNLLSTGNR
K-TR-NLVLKVLLNMSENPAAARDMIDTK---ALAALKLIFNQKEAK----------ANL
VSAVAIFINIKEHIRKGSIVVVD----------HQSY--NTLM-AIFREVKMIIETL---
------------------------------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
---------------------------------MGRTREAGCVAAG----------VVIG
AGACYCVYRLA--WGRDE-NEKIWD----EDEESTDT--SE-------------------
-----------------------------TGVETV------KGAKTNVGAGSGAKLQGDS
-----------------------------KV------------KPEVSLGLEDCPGVKEK
AHS----------------G--------SHSGGGLE---AKA------------------
-----------------KALFNT-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------L----------------------------------
----------------KEQASAKAGKGARVGTIS--------------------------
---------------------------------------------GNRTLAPSLPCPGGR
GG---------GCHPTRSGSRA---------------------------------GSRAS
GKSKGKARSKSTRAPA-T---------------------------TW----PVRRGKFNF
PYKID--------DILSAPDLQKVLNILERTNDPFIQEVALVTLGNNAAYSFNQ------
----------NAIRELGGVPIIAKLIKTKDPII------RE-KTYNALNNL-SVNAENQG
KIKTYISQVCDDTMVCRLDSAVQMAGLRLLTNMTVTNHYQHLLSYSFPDF-FALLFLGNH
F-TK-IQTMKLIINFTENPAMTRELVSCK---VPSELISLFNKEWDR----------EIL
LNILTLFENINDNIKNEGLASS---------RKEFSR--SSLFF-LFKESGVCVKKIKAL
A-NHNDLVVKVKVLKVLTKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------MTRAEVEPGAQAKAENKPGDENA--------N-----------AAEVEPEAPL
VVRPKV--------------------------RT--QIMTGARPKVKPKGTPGARPKG--
------------------------------------------------------------
------------------------------------------------E------TSTPG
GAYAKC--KPKAIPIARSKHDA--------------Q--------------VWAPNKFR-
-----GESMSKMGKQCQISAADPPLLSNDS--GMVAQAKCLPVDRELANMDTESIPKK-A
NSPAGFQPSFGSE-EGTN------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---MGSWYRPRPVPK-GEAYENSDFKWADKPSGSPSFWNRDEASTRFRPRKSMKA-NNRF
RHMAKQE-----A--NTMPRHKNKQEFYNIS-SSDSE-----------------------
-DESGKTPWFWPKDKTKVWS--KPKEEP-NSRSWFRSKKEVRV------------ESTSG
SECENPTKSLFWSGEEAKSRSKPRARKGVNMRARQQAKREACSDAMSAAI------DTNK
KESWFLPEEKT---------NAF-----SKSKTKKEPRTRAVPK----------------
EE----VKTKARASTKQEARP-----EEEVLVGAWFWDTQESTMADRISIKT-TFVEEEP
IVGDWFWSEEEASVDSETCHTS-RPRAKEEQVSSFCLGSG-KKSSMESGPKATSKSMPVA
KED-EVVIGSWFWADDEEIN---------------------------------LQADDES
IFGSWFWGTGEHS-LRS-VGVNCE-------------------------------KMPK-
V-GEKEVTDPWFWAGD-VNPEAEVEEQ----------ARSASTKATIFVPWFWSEKQPNM
DLG------SEPCSDIMAGTE-----EEPIIGPWFWAKVDNSVEAEVNSKSSLEDEEE-P
IRSPWFGAREQTDMKYAAGVRYKPMAEAEDANKKSCVWAK-EPCLYPTNRECLKSTLGEK
-----EDTVDPWLWSNNYPRTKSITG------------------------SWLWAAEEGN
IDDETGEKIKLPTLEDNAFNSWFWKENEETIIEAPNREESRPEAEEEDIIGSWFWAGDED
RFQPAAKTNEENK-IASEEEDTVGSWFWGNEE----------------------------
---ASLEAVRRGTFESAPGIKEE-----KVSGSWFWTDK-AKVGAGSQT-VETGSETEEE
AIFESLIWAAKK-----DSMQAGVKRVPKPKDE-GDIA----------------------
-VGSWLWSSDKATKEAKTLIVSEASPENGKESVVKFGSRAKDEVINKTGSGDNCKHSA--
-EAETIVGAWFWEGDEASFES-NPVPVCKAICEPESSAEHEPDPSRRPQSWDEVTVQFKP
-GPW----GKAGFPPMNPFRFPKEA-ASLFAEMFGGKPKLVEVGP-E------------R
---E--PEPRFPFQYDPSY--------------------RSVREIREHLKARESAQPENW
SCNCIQ-----CELRIGSEEFEELLLLMDRNRDPFIHEISKIAMGMRGASQFTR------
----------DFIRNSGVVSLIEALLNYPSSRV------RT-RFLENMVRM-APPYPDLN
MIETYVCQICEDTFDYDLDSPDQLSGLTMITHLTATSDYHKVVVNYLAGF-FYLLNSGNT
K-TR-FHVLKLLLNLSENLVMTKRLLVTD---SVSEFMDLINREESD----------ENI
QIVLAIFETISKHIQKEALFSDDDDDDDDEEEDAVNL--EPFI-SAFREAEKIAKELKRK
PGNQKAP-----------------------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
-------MTGAEVETGSQAKPDKKPQEEV--------AG-----------GAERESEAPL
VVRPKV--------------------------RPQAPATSGARPKTETKSSSRARPKTET
------QSVSGT------------RH---------------------------------R
MSGARPRS----------------------------EAQLMSGARPKTD------ARAVG
GARPKT--EAKPIPGARPKGDA--------------Q--------------AWAHSEFG-
-----AEAMPRAERAHLSNSVTWPPVNAGS--ATVTKSKSLSMNTELASMGSEIFSGTQ-
-GQPGIEPWFGPR-EEAN------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---MGPWCYPRPRAR-EETSNES----ADENSTMSSFWTREETSIRSWPREEV---NTRS
RHRAKHQ-----T--NARSKPRSKQDPYIDS-LSGSE-----------------------
-DEASNPFCFWAGENTNDMF----------------------------------------
---------------------RARGRDEANARPKIRTKREDY--FED--E------DEIY
KESWLLPGEEG----------NR-----FRRRDKEEPNKTLKNE----------------
NE----KDVKNDETVEQESRL-----EEEVIIGSWFWAEQET------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------NV
EAG------ASAICDTEPVAE-----EGAI------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------GGSLFWTEEKP
SLGA--------------------------------------------------------
-----------------------------------------------VARDEVRPES---
------------------------------------------------------------
------------------------------------------------------------
-EEEALFGSWFWDRDEACFDP-NPTPVYTAKSRYRDPE-EDLNLASRPKTWDEVTIEFKP
--PC----HGLGFPSPRPFIIPEGAS-----GNSEEKAKNAELGAEG----E--EQDSVV
QRDL--PEPEFPFQYDPSY--------------------RSVQEIREHLKARESAQPENW
SCTCIQ-----CELRISSAEFEELLLLMDRIRDPFIHEIAKIAMGMRTASQFTR------
----------DFIRDSGVVSLIEALMNYPSSRV------RT-NFLENMVHM-APPYPNLN
MIETFICQVCEETLSHTVNSPEQLTGMRMLRHLTITTDYHVLIANYVSGF-LALLTTGDA
R-TK-FHVLKMLLNLSDNPMVAKKLFSAK---ALSIFVGLFNIEETN----------DNI
QIVIKMFQNISNIVKSGAMSLLD---------DDFSL--EPLV-SAFHEFEELAKQLQIQ
IDNQNDPEEGQ-------------------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MTGAKN--KARAQAKAEKK-A
SVQAKAAVEKQAHTV------VKPA---------------------AKVHTKGKAKAGPK
-----VDAV---------------------------------------------------
------AEVKTV-------------SKNRG-AEVKEGTRSEPKAPVKVT-----------
------SD----------------------------LPKAENKATSSACKDKAGTDNWFW
AGEE------------------------ASINSWFWKGEEAGN-RSVT------------
---------KYENK-------TDAGAQSSV----E-------------------------
------------VIEPVTRVGCKSRTGFEE------------------------------
EEEENVIGNWFWEGDVTGFEP-DPKPVYRIVRPQP---VDEINEKNRPKDWSEVTIWPKA
PAVTP---AVLGFRSQAQSETRPSS----YIVLASNEENNP-------------ASSSKG
TRSNSQPIPEYPFGSDPCI--------------------QTLEEIRQQIKIRETNGIKPF
ACPCKM------ECYMDSGEFEKLVSILKSTTDPLIHKIAQIAMGIHKVHPFAQ------
----------EFINEVGVVTLIESLLSFPSQDV-------RKKTVITL-NP-PSGDERQQ
KLEIHVKHMCKETVSFPLDSPGQQSGLKILGQLTTEPVHHYIVAGYFSEL-FHLLSQGNR
K-TR-NLVLKLLLNMSENPNAARDMINMK---ALAALKLIFNQNEAK----------ANL
VSAVAIFINIKEHIRKGSIVVVD----------HMSY--NMLT-AIFREVKGIIEAM---
------------------------------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
---------------------------------MRGARDVRWAAAG----------LSS-
---------------------------------VLRP--SR-------------------
------------------------------------------SAE---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------DSTNALVTVGNNAAFSVNQ------
----------AIICELGGIPIVGNKINSPNPNI------KE-KALNALNNL-SVNVENQI
KIKVYINQVCEDVFSGSPNSVVQLAGLRLLTNMTVTNDHQHMFELHYRP--VPGLLTGNG
N-TK-VQVLKLLLNLSENPAMTEGLLGAQ---VDSSFLSLYDGHIAK----------EIL
LRVLMLFENINNCLRMEGYLVV---------QPIFTN--GSLFFLFYGE--ECAQKIRAL
V-HHHDAEVKEKAVTIIPTI----------------------------------------
-------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
---------------------------------MGRTREAGCVAAG----------MVIG
AGACYCVYRLT--WGKDE-NEKLWD----DEEEEEEE---EEESC---------------
------------------------S------DKTE------KGVKTNVGVGAG--PQDDS
-----------------------------KP------------KADVKVGQENDPGVKIE
AHP----------------E--------SQGEGGLE---AKA------------------
-----------------KALFKI-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------L----------------------------------
----------------KEQASAKAGRGIRFANIS--------------------------
---------------------------------------------GTRTLSSGLPCPGGR
GG---------GCHPGRSGARA---------------------------------RSRAS
GKAKRKNRSKSTKAPA-T---------------------------AW----PVRRGKFNF
PYKID--------DILSAPDLQKVLNILERTNDPFTQEVALVTLGNNAAYSFNQ------
----------NAIRELGGVPIIAKLIKTRDPII------RE-KTYNALNNL-SVNSENQG
KIKTYISQVCDDTMICRLDSAVQMAGLRLLTNMTVTNHYQHLLSYSFPDF-FALLFLGNH
F-TK-IQTMKLIINFTENPAMTRELVSCK---VPSELISLFNKEWDR----------EIL
LNILTLFENINDNIKSEGLASS---------RKEFSR--SSLFF-LFKESGVCVKKIRAL
A-NHKDLVVKVKVLKVLTKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
-----------------------------------------------MGRARE--VGWVA
AGLM----IGAGACYCVYKLTI------------GR--DDSDKLEE------EEEEEWEN
D-ELDEEEPDIWFDLTTITRPWSEDGDWTEPGAPGGTEDRPSGGGKANRA--HPIKQRPF
PYEHK--------NTWSAQNFKNGSCILDLSKSLFIQGKMFFAESKNVCFSFSH------
----------DINSPLASLSMVGNMIPTPDPTV------G--EALCAPDNL-NASIEKQG
QIKMYLIEVCRETVLRCCNSFLQQAGLNLLISMTVINN---MLAKSVSDLKFPLISEESG
C-AK-VQLLKPLMGLSEKPVLAGELLSAQ---MLLSSVTLFIRNGNR----------EMP
VETLAL------------------------------------------------------
------------------------------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------MAGSRARARTRR------RDG--------LQGH----
------SQARAQAKTQAKTVA-----VAKLKTESV----TQAKAGDGAVSKTQRIAQTET
--VAVTKEVSKM------------------------------------------------
------------------------------------------------------------
-----------KGMSKAKVIAETHTKTVT-QPRVVPQIKPKAMPSSSI--GAITQSKIKT
D-----------------------------------------------------------
-------AGNEVNISSCVKAA-----DMASIESRPQI-----------------------
--------REEA------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------SIGL-----------------------------KSNDKDEENVCSWLW
TEKE------------------------SSIGSRFWSEEEAPPQV---------------
-----YNPPPT---------------------I-NDKP----------------------
------------------------------------------------------------
----------------------ELTPR------------------------SELTIRQKA
ATTW----LRA--RYSVLVPIN------------VR--ELF-LPP---------ERNWIL
IETLIET--------PLGIKLLTKISPYSGPYFQTLAE------IKHHIRYGETYGPNPK
NCHCKT-----YSFNLEPKEFDRLIALLKFTKDPFIHEIATMVMXXXXXXXXXX------
----------XXXXXXXXXXXXXXX------------------XXXXXXXX-XXXXXSIT
NESSYVNQICKDIISYPLNSIVQLSGLKV-VSLSLKFSDHYTIIKYIPDI-L-LLNNGNA
R-TK-FFILKVFSYLSKNQANLRELISAE---VLSSLVALFNKNESK----------FSI
LAIVETFENINYQFKQGVKLFTK--------DQ-FTK--DELI-SIFQEAKEFSQKLQDL
A-EHNDPEVRDKIAQLILKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------MTGAEIESSAQAKPEKKAGQEGG--------A-----------GTERENEVLM
VVRPKV--------------------------RTQAHVMTGARPKTDSKAMSGARPKTDS
------KKMTGA------------------------------------------------
----RTKK----------------------------ESKAMTGARPKTD------ARAVG
GARPKT--NAKSKTSSRSKDET--------------Q--------------AWTQTDFG-
-----TEAILQAEGMPQANAAVWSLANVES--GSVAKSMGLSVDRDLVGVDADTFPGSH-
-VQTGIQPWFGPG-EEAN------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---MGSWCYPRA--R-GEASNESGFWSEDDTTTLSSFWAGEENSIRSWPREEV---NTRS
RHRAKHQ-----S--NSRPIPRSKQDPYIDS-WSGSE-----------------------
-EESCNPYCFWGGENCNDLF----------------------------------------
---------------------RPRGRNETNIRSKLRTKREDF--FESESE------DEYY
KESWFLPGEET---------SNR-----FRNRCKEEPDTILKSR----------------
TQ----KDVNKSERVKQDPRC-----EEEVIIGSWFWEENED------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------GM
EAG------ASAICDSRPEDE-----EGAI------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------GGCLFWNEDKS
DLGA--------------------------------------------------------
-----------------------------------------------MAGEEALPES---
------------------------------------------------------------
------------------------------------------------------------
-EEDAIFGSWFWDRDEASFDQ-NPCPVFKACPRFRESAEEDLSVSSRPQAWEDVSVEFKP
-GPC----HGMGFPSLTPFQIPEEAVASVYAEVFDVNPNNVELNLEE----E--EQESLL
PPDQ--PEPQFQFQYNSSY--------------------RSVMEIREHLKAKESAEPENW
SCNCIQ-----CELKIGSGEFEELLLLTEKVRDPFVLEISKIAMGTRNAPQFTR------
----------DVIRDSGVVSLIEALLNYPSSRK------RT-DFLEDMIRV-SPPYPSLN
MIETFVYQVCEETLATGMGSPEQLLGLRILRHLTTTTDYHALVAGFMSGF-LSLLATGNA
R-VK-FNVLKMLLNLSENAVVAQKLFSAN---ALSVFVTLFNVEEAD----------DNI
QIVVRMFKNISVIVNNGMMALID---------EDFSL--EPLI-CAFHEFENLALEIQTQ
LDNQDDTEVEKQS-----------------------------------------------
-------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
---------------------------------MGYARKVGWVTAG----------LVIG
AGACYCIYRLT--RGRKQNKEK-MA----EGGSGDVD--DAG----------------DC
---------------------------------------------------------SGA
--RYNDWSDDD-------------------------------------------------
DDS----------------N--------E-------------------------------
------------------------------------------------------------
-SKSIVWYPPWAR-----------------------------------------------
------------------------------------IG----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------T--------------------------------
-----------EAGTRARARA---------------------------------------
------------------------------------------------------------
-------------RARAT---------------------------RA----CRAVQKWAS
PNSDD--------TVLSPQELQKVLCLVEMSEKPCILEAALIALGNNAAFTFNR------
----------DIICDLGGLPIVAKLLNTRDPIV------KE-KALIVLNNL-SVNAENQR
RLKVYMNQVCDDTITSRLNSSVQLAGLRLLTNMTVTNEYQHMLANSISDF-FRLFSAGNE
E-TK-LQVLKLLLNLVETPAMTRELLRAQ---VPSSLGSLFNKKEDK----------EVI
LKLLVIFENINDNFKWEENEPT---------QNQFGE--GSLFF-FLKEFQVCADKVLGI
E-SHHDFLVKVKVGKFMAKLAEHMFPKSQE------------------------------
-------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MGGARDAGWVAAG----------LV--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------DLT
NASYD--------DVLNAEQLKKLLYLLESTEDPVLIEKALVTLGNSAAFSANQ------
----------AIIRELGGIPIVGDKINNPDHSI------KE-KALNALNNL-SVNVENQI
KIKIYINQVCEDIFSGPLNSAVQLAGLRLLTNMTVTNDHQHMLSRSIADL-FHVLLTGDG
S-TK-VQVLKLLVNLSENPAMTEGLLSAQ---VDSSFLSLYDSHVAK----------EIL
LRVLTLFHNINNCLKMEGHLAI---------QPPFPK--GSLFFLLYGE--ECAQKMRAL
V-YHHDEDVKEKVVTVIPKF----------------------------------------
-------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------MTGAEIEPAARAKPEKKAGEEVG--------G-----------GAERENEVPM
VVRPKV--------------------------RTQAQVMPGARPKTESKSMPGARPKTES
------QAMAGARPKTESQAMAGSRPKT----------------------------ESQG
MAGTRAKI----------------------------ESQSVVGARPKAE------ARTVG
GARPKT--EAKAIPGAKPKGEA--------------Q--------------AWPQTEFG-
-----AEAMSQTEGLAQTSAVAWPLVSTES--RPVAKPMALSVDRELVGVDTETFPGSQ-
-VQTGIQPWFGSG-EEVN------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---MGSWCYPRHRAR-EEASNESGFWSADETSTMSSFWAGEETSIRSWPREEA---NTRS
RHRAKHQ-----P--NPRSRPRSKQDPYVDS-WSGSE-----------------------
-EESGNPFCLWAGENTNNLF----------------------------------------
---------------------KPRVRDEETMRSKLRTKREDF--FESESE------DEYS
KESWFLPGEEA---------NGR-----FRTRDQEEPNTVLKPK----------------
GQ----KDVNNSGRVKQEPRF-----EEEVIIGSWFWAEKEA------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------SM
EAG------ALAICESTPRSE-----EGAI------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------GGSLLWTEEKS
NLGA--------------------------------------------------------
-----------------------------------------------LAREEARPES---
------------------------------------------------------------
------------------------------------------------------------
-EEEAIFGSWFWDRDEACFDL-NPSPVYKASSRFRDSAEEELKASSRPQTWEEVTVEFKP
-GPC----HGVGFPSPSSFRIPEEA-ASVFSDMFEGKPKNLEFSPEG----E--GQESLL
QSDQ--PEPEFPFHYDPSY--------------------RSVREIREHLKARESVAPESW
SCSCIQ-----CELKIGTGEFEELLLLMDKIRDPFIHEISKIAMGMRSASQFTR------
----------DFIRDSGVVSLIETLLNYPSSRV------RT-SFLENMIHM-APPYPNLN
MIETFICQVCEETLAHSVSSPEQLLGLRMLRHLTTTTDYHTLVANYMSGF-FSLLTTGNA
R-TK-FHVLKMLLNLSENPVVAKKLFSAK---ALSIFVGLFNIEETN----------DNI
QIVIKMFQNISNIIKNGTMSLID---------DDFNL--EPLI-SAFHEFEKLAKELQVQ
IDNQNDPEMGRQS-----------------------------------------------
-------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------MTKAEMEPGAQAKAESKPGDENA--------N-------TNTN----ESEAPM
VVRPKV--------------------------RT--QIMPGARPKVRPKTTPAPRPRS--
------------------------------------------------------------
------------------------------------------------E------ASAPA
GAYAKC--KPKSIPIARSKNDA--------------Q--------------VWAPNRFR-
-----AEPMSKMGKQCQINPADSPLVNTDS--GMVAQAKCLSVDREHGHMDTESFPRK-A
NSQAGYQPSFGSE-EGTS------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---MGSWYRPRPTPK-GEAYENSDFRWADKPSGSSSFWNRDETSARFRPRKNMKPSNTRF
RHMPKQE-----A--NSMPRHKTKQELYNIS-SSDSE-----------------------
-EESAKTPWFWAKEKPKVWS--RPREEP-NNRSWIRPKKEVRV------------ESSSG
SECENQTKSSFWSGEDAKSRPKPRARKGMNTRARHQAKREAGSE--SASV------DTNK
KESCSFPEDKA---------SAL-----SKSKPKKEPKTRAVPK----------------
EE----VKTKARATTKREARA-----EEEVFIGAWFWDTQEPRMVDRVSPKASLLVEEEP
FVGDWFWSEEETSVDSETCCKP-RRRAKEEQVRAFSLGSG-KKTSMENGPKPTSKSVPVA
NEEEKNIVGSWFCADDEDIN---------------------------------LEAEDES
IFGSWFWGVGENS-LRS-VGVSYE-------------------------------KML--
KSGEKEVTDSWFWARE-VNPEAEVEEQ----------ARPASAKGTIFVPWFWSEK----
NLG------TEPCSDIMAGAE-----EEPIIGPWFWAKVDNSADIDDSSKSSLEDEEE-P
IISPWLGAREQANMKYAAGARYKPVAEAGENNKRSDFWAK-EPSLCHANRQILKSTLREQ
-----ENTVDSWLWSNNYPRKQAIAG------------------------SWLWAAEEGN
IDDETGEEIKLPTLEDNILNSWFWKENEETVVEAANREESKPEAEEEDIIGSWFWAGDEN
RFQPATEINEENK-ITSEEEDTVGSWLWGKEE----------------------------
---ASLEAMRRGTFESTPGIKEG-----KIK-------------------------TEEE
AIFQSLIWAAKK-----DNVRAGVNRVSKPEN----------------------------
----------------------------EKGPNVEVRSSAKDEVINKAGSGDNCESNA--
-EAENIVGSWFWEGDEASFES-NPTPVFKAVCKPKSSAEQEPDPSRRPQSWDEVTVQFKP
-GPW----GKAGFPSISPFRFPKEA-ACLFAEMFGGKPKQEGEEESS------------C
---Q--SENGFPFQYDPSY--------------------RSVREIREHLKVRESADPESW
SCSCIQ-----CELNIGSEEFEELLLLMDRNRDPFIHEISKIAMGMRSASQFTR------
----------DFIRNSGVVSLIEALLNYPSTRV------RT-RFLEDMVSM-APPYPDLN
VIQTYVCQVCEDTFDYDLDSPEQLSGLSMITHLSATSDYHKVVGKYLAGF-FYLLNSGNT
K-TR-FHVLKLLLNLSENLIMTKRLLATE---SMSEFMTLFSKEDSN----------DNI
QIVLAIFDKISKNIQKEALFADDDD---EEEEVVVNL--DPLI-SAFHEIENFAKTLKRK
PDN---------------------------------------------------------
-------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MGYARKVGWVTAG----------LVIG
AGACYCIYRLT--RGRKQNKEK-MA----EGGSGDVD--DVG----------------DC
---------------------------------------------------------PGA
--RYNDWSDDD-------------------------------------------------
DDN----------------S--------E-------------------------------
------------------------------------------------------------
-NKGIVWYPPWAR-----------------------------------------------
------------------------------------IG----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------T--------------------------------
-----------EAGTRARARA---------------------------------------
------------------------------------------------------------
-------------RARAT---------------------------RA----RRAVQKRAS
PNSDD--------TVLSPQELQKVLCLVEMSEKPYILEAALIALGNNAAYAFNR------
----------DIIRDLGGLPIVAKILNTRDPIV------KE-KALIVLNNL-SVNAENQR
RLKIYMNQVCDDTITSRLNSSVQLAGLRLLTNMTVTNEYQHMLANSISDF-FRLFSAGNE
E-TK-FQVLKLLLNLAENPAMTRELLRAQ---VPSSLGSLFNKKENK----------EVI
LKLLVIFENIIDNFKWEEDEPT---------QNQFSE--GSLFF-FLKEFQVCADKILGI
E-SHQDFLVKVKVGKFMAKLAEHMFPKSQE------------------------------
-------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MGGPRGAGWVAAG----------LLLG
AGACYCIYRLT--RGRRR-GDR---------ELGIRS--SK-------------------
------------------------------------------SA----------------
------------------------------------------------------------
-------------------------------GA-LE---EG-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------TS-------------------------------
------------------EGQ-L----CGRS--------------AR---------P-QT
GG---------------TWESQ------------WSKTSQ--------------------
-----------PE--------------------------------------------DLT
DGSYD--------DVLNAEQLQKLLYLLESTEDPVIIERALITLGNNAAFSVNQ------
----------AIIRELGGIPIVANKINHSNQSI------KE-KALNALNNL-SVNVENQI
KIKIYISQVCEDVFSGPLNSAVQLAGLTLLTNMTVTNDHQHMLHSYITDL-FQVLLTGNG
N-TK-VQVLKLLLNLSENPAMTEGLLRAQ---VDSSFLSLYDSHVAK----------EIL
LRVLTLFQNIKNCLKIEGHLAV---------QPTFTE--GSLFFLLHGE--ECAQKIRAL
V-DHHDAEVKEKVVTIIPKI----------------------------------------
-------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MGGARDVGWVAAG----------LVLG
AGACYCIYRLT--RGPRR-GGR-----------RLRP--SR-------------------
------------------------------------------SAE---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------DLT
EGSYD--------AILSAEQLEKLLYLLESTDDPIITEKALVTLGNNAAFSTNQ------
----------AIIRELGGIPIVGSKINSLNQSI------KE-KALNALNNL-SVNVENQT
KIKIYVRQVCEDVFADPLNSAVQLAALRLLTNMTVTNDYQHLLSNYITGL-LHLLLIGNG
S-TK-VQVLKLLLNLSENPAMTEGLLSAQ---VDSSFLSLYDGQMAN----------EIL
LRALTLFQNINNCLRVEGRLAN---------QLPFAK--GSLFFLLYGE--ECAQKMKAL
A-CHPDVDVKEKALAIKPKF----------------------------------------
-------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MGGAREVGWVAAG----------LVLG
AGACYCIYRLT--RGRRR-GGS---------RLKLCS--SR-------------------
------------------------------------------SAG---------------
------------------------------------------------------------
-----------------------------------E---AG-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------RQ-------------------------------
------------------SGQ-F----CLHS--------------AG---------PLER
RG---------------TLESP------------WSRISQ--------------------
---------------L-------------------------------------V---YLT
NGSYD--------EVLNAEQLQKLLYLLESTEDPVIIERALVTVGNNAAFSVNQ------
----------LLNLS----------------------------------------EPQFL
IYTIYINQVCEDVFSGPLNSAVQLAGLRLLTNMTVTNDHQHMLQSYITDL-FQVLLTGNG
N-TK-VQVLKLLLNLSENPAMTEGLLSAQ---VDSSFLSLYDGHVAK----------EIL
LRVLTLFQNINNCLKMEGRLAV---------QPTFTN--GSLFFLLYGE--ECAQKIRVL
V-HHHDAEVKEKVVTIIPTI----------------------------------------
-------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------MTGAEIETGAQAKPEKKAGEEVG--------G-----------GAERENEVQM
VVRPKV--------------------------RTQAQVMAGARPKTESQVMAGARPKT--
----------------ESQVMAGARPKT----------------------------ESQV
MAGARPKT----------------------------ESQGIPGARPKTE------ARAVG
RARPKT--EAKAIPGARLKDEA--------------Q--------------AWAQTEFG-
-----AEAVSQTEGVPQINAVAWPLVSTES--RPVAKPMTLPVDRELVSVGAETFSGSH-
-GQSGIQPWFGSG-EETN------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---TGSWCYPRPRAR-EEASNESGFWSADETSTMSSFWAGEEASIRSWPREEA---NTRS
RHRAKHQ-----P--NPRSRPRSKQDSYIDS-WSGSE-----------------------
-EESGNPFCLWAGENTHNLL----------------------------------------
---------------------RPRVRDGANVRSKLRTKREDF--FEPESE------EEYY
KESWFLPGEEA---------NSR-----FRPRDKEEPNTVLKPR----------------
AQ----KDVNNGDRVKREAGF-----EEEVIIGSWFWAEKEA------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------GM
EAG------ASGLPESTPEAE-----EGAI------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------GGSLFWTEEKS
SLGA--------------------------------------------------------
-----------------------------------------------VAREETRPES---
------------------------------------------------------------
------------------------------------------------------------
-EEEAIFGSWFWDRDEACFDL-NPSPVYKASPRFRDSAE-ELNTSSRPQTWEEVTVEFKP
-GPC----YLVGFPSPSPFRIPEDT-AAAFAEMLEGKPQSAELTPEG----G--DKEPLP
QANQ--PDPEFPFQYEPSY--------------------RSVREIREHLRTRENAEPESW
FCSCIQ-----CELKIGSGEFEELLLLMDKIRDPFIQEISKIAMGMRSASQFTR------
----------DFIRDSGVVSLIETLLNYPSSRV------RT-RFLENIILM-APPYPNLN
MIETFICQVCEETLAQNVNSPEQLLGLRLLRYLTTTPDYHTLVANFMSGF-LSLLVTGNA
T-TK-FHVLKMLLNLSENAVVAKKLFSAK---ALSIFVGLFNIEESN----------DNI
QIVIKMFRNISHSIRNGTMALID---------DDFSL--EPLI-AAFHEFENLAKELQTQ
IDNQNDPEGGKES-----------------------------------------------
-------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
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-----------------------------------------------MGRARE--VGWMA
AGLM----IGAGACYCVYKLTI------------GR--DDSDKLEE------E-EEEWDE
DEELDEEDPKMWVDFTTMARPWSEDGDWTKPGAPGGSEDRPSGGGKANRT--YLIKERPS
PYGHK--------NTWSAQRFNNISTVLDLSKCPFIQVKMLFTQSKEAGFSSSH------
----------KINSPLASFQVVRNIIPTPRPTV------KE-KAMCSLYNL-NVNVENQV
QIKMYISEVCRETVSRCCDSFLQQAGLNLLISMTVINN---MLAKSVADLKFPLISEGCG
C-AK-VQVLKLLMGLSEKAALAGELLGAQ---MLFSFMSLFIQNGNR----------DIL
LDILAP------------------------------------------------------
------------------------------------------------------------
-------------------------------------------

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-------MTGAEIESGAQVKPEKKPGEEVV--------G-----------GAEIENDVPL
VVRPKV--------------------------RTQAQIMPGARPKNKSKVMPGASTKV--
------------------------------------------------------------
------------------------------------------------E------TSAVG
GARPKS--KAKAIPVSRFKEEA--------------Q--------------MWAQPRFG-
-----AERLSKTERNSQANIIASPLVNTDS--VLVAKTKYLSEDRELVNTDTESFPRRKA
HYQAGFQPSFRSK-EETN------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---MGSWCCPRPTSK-QEASPNSDFKWVDKS-VSSLFWSGDEVTAKFHPGNRVKD-STRS
RHMANQE-----A--NTMSRSQTNQELYIAS-SSGSE-----------------------
-DESVKTPWFWARDKTNTWS--GPREDP-NSRSRFRSKKEVYV------------ESSSG
SEHEDHLESWFGAGEEAKFRSKMRAGKEANNRARHRAKREACIDFMPGSI------DVIK
KESCFWPEENA---------NTF-----SRPMIKKEARARAMAK----------------
EE----AKTKARARAKQEARS-----EEEALIGTWFWAIDESSMADEASIESSLQVEDES
IIGSWFWTEEEASMGTGASSKS-RPRTDGEPIGDSLFGAR-EKTSMKTGAEATSESILAA
DDE-QVIIGSWFWAGEE-VN---------------------------------QEAEEET
IFGSWFWVTDAAS-VESGVGVSCE-------------------------------SRPR-
-SEEEEVIGPWFWSGEQVDIEAGIGEG----------IPPEAEEETIFGSWFWAENQTYM
DCR------AEASCATMQGAE----EEEPIIGSWFWTRVEACVEGDVNSKSSLEDKEE-T
MI-PCFGAKEEVSMKHGTGVRCRFMAGAEETNNKSCFRAEKEPCMYPASGGSWKARPEEE
-----EDIVNSWFWSQKYTKPEAIIG------------------------SWLWATEESN
I-DGTGEEPKLLTEEETMINSWFWKED-EAISEATDREESRPEAEEGDIIGSWFWAGEED
RLGPAAETREEDRLAAEKE-GIVGSWFGAREETIRREAASCSKSSPKAEEEEVIIGSWFW
EEEASLEAVAGVGFESKPGTEEE----EITVGSWFWPEEEASIEAGSQAVEEMESETEEE
TIFGSWFWDGKE-----VSEEAGPCCVSKPEDD-EEMI----------------------
-VESWFWSRDKAIKETGTVATCESKPENEEGAIVGSWFEAEDEVDNRTDNGSNCESRTLA
DEDGAIVGSWFWAGDEAHFES-NPSPVFRAICRSTCSVEQEPDPSRRPQSWEEVTVQFKP
-GPW----GRVGFPSISPFRFPKEA-ASLFCEMFGGKPRNMVLSPER----E--DQESLL
HPDQ--PDPEFPFQYDPSY--------------------RSVQEIREHLRAKES------
-------------LKIGSEEFEELLLLMEKIRDPFIHEISKIAMGMRSASQFTR------
----------DFIRDSGVVSLIETLLNYPSSRV------RT-SFLENMIRM-APPYPNLN
MIQTYICKVCEETLAYSLDSPEQLSGIRMIRHLTTTTDYHTVVANYMSGF-LSLLATGNA
K-TR-FHVLKMLLNLSENLFMTKELLSAE---AVSEFIGLFNREETN----------DNI
QIVLAIFENIGNNIKKET-VFA---------DDDFNL--EPLI-SAFHKVEKFAKELQGK
TDNQNDPEGDQEN-----------------------------------------------
-------------------------------------------

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---------------------------------------MTGTKN--KARGQAKTEKRGT
KVQAKGGAEKEVTGA------VKPV---------------------AKSRSKTKAKAGYK
-----ADVV---------------------------------------------------
------AETKVV-------------SKNRVVAEVKEGALSEPKAPVKAI-----------
-----TGI----------------------------SSKAENGVTSSTCKDKAGIDTWFW
AGEE------------------------ANINSWFWKGEEAGN-HSSA------------
---------KDENK-------AHIAAQVCA----E-------------------------
------------ESESVAGASCKSVSGVDE------------------------------
-EEENVIGNWFWEGDDTSFDP-EPKPVYRIVRPLP---VNEINQKNRPKDWSEVTIWPKA
PAVTP---AVLGFRSQVPAEARPSS----YVVVSSAEESTHSSSSSAAAAAAAAACSSKN
TCSGSQSIPESPFGSDRCI--------------------QTIDEIRQQIRIREANGIKPF
ACPCKM------ECYLNSEEFEKLVSILKSTTDPLIHKIAQIAMGIYNVHPFAQ------
----------EFINEVGVVTLIESLLSFPSPER-------RKKTVITL-NP-LSGDERQR
KIELHVKHMCKETVSFPLNSPGQQTGLKILGQLTTDSVHHYIVASYFSEL-LQLLSQGNR
K-TR-NLVLKVLLNMSENPTAARDLINMK---ALTALKLIFNPKEAK----------ANL
VSAVAIFINIKEHIRKGSIVVVD----------HLSY--NTLT-DIFREVKGIIEAM---
------------------------------------------------------------
-------------------------------------------

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------------------------------------------------------------
---------------------------------MGRTREAGCVAAG----------VVIG
AGACYCVYRLT--WGRDE-NEIIWN----EDDDEEEE--SRD------------------
------------------------------ISETG------KGAKANAGAGAGARLQGDA
-----------------------------KA------------KAEVAVELKSGPDVKAE
AHS----------------K--------AESGGGLE---AKA------------------
-----------------KALFSTL--------------K---------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------EQASAKAGKAAKLGTIF--------------------------
---------------------------------------------GTRALAPGFPCLGVR
GG---------GCHPVRSGARA---------------------------------GSKDS
GKSKGRTRNKSTRSPA-M---------------------------LW----PVRKGKFNF
PYKID--------DILGATDLQKVLNILERSNDPFIQEVALVTLGNNAAYSFNQ------
----------NAIRELGGLPIIAKLIKTKDPII------RE-KAYNALNNL-SVNSENQG
KIKTYISQVCDDTMLCRLDSAVQMAGLRLLTNMTVTNHYQHLLSYSFPDF-FALLFLGNY
F-TK-IQIMKLIINFTENPAMTRELVSCK---VPSELISLFNKEWDR----------EIL
LNILTLFENINDNIKNEGLASS---------RKEFSR--SSLFF-LFKESGVCVKKIKAL
A-NHSDLVVKVKVLKVLTKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
-------MTKAEMEPGAQAKAESKPGDENA--------N-------TNTNGAEGESEAPM
VVRPKV--------------------------RT--QIMPGARPKVRPKTTPAPRPRS--
------------------------------------------------------------
------------------------------------------------E------ASAPA
GAYAKC--KPKSIPIARSKNDA--------------Q--------------VWAPNRFR-
-----AEPMSKMGKQCQINPADSPLVNTDS--GMVAQAKCLSVDREHGHMDTESFPRK-A
NSQAGYQPSFGSE-EGTS------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---MGSWYRPRPTPK-GEAYENSDFRWADKPSGSSSFWNRDETSARFRPRKNMKPSNTRF
RHMPKQE-----A--NSMPRHKTKQELYNIS-SSDSE-----------------------
-EESAKTPWFWAKEKPKVWS--RPREEP-NNRSWIRPKKEVRV------------ESSSG
SECENQTKSSFWSGEDAKSRPKPRARKGMNTRARHQAKREAGSDGLSASV------DTNK
KESCSFPEDKA---------SAL-----SKSKPKKEPKTRAVPK----------------
EE----VKTKARATTKREARA-----EEEVFIGAWFWDTQEPRMVDRVSPKASLLVEEEP
FVGDWFWSEEETSVDSETCCKP-RRRAKEEQVRAFSLGSG-KKTSMENGPKPTSKSVPVA
NEEEKNIVGSWFCADDEDIN---------------------------------LEAEDES
IFGSWFWGVGENS-LRS-VGVSYE-------------------------------KML--
KSGEKEVTDSWFWARE-VNPEAEVEEQ----------ARPASAKGTIFVPWFWSEK----
NLG------TEPCSDIMAGAE-----EEPIIGPWFWAKVDNSADIDDSSKSSLEDEEE-P
IISPWLGAREQANMKYAAGARYKPVAEAGENNKRSDFWAK-EPSLCHANRQILKSTLREQ
-----ENTVDSWLWSNNYPRKQAIAG------------------------SWLWAAEEGN
IDDETGEEIKLPTLEDNILNSWFWKENEETVVEAANREESKPEAEEEDIIGSWFWAGDEN
RFQPATEINEENK-ITSEEEDTVGSWLWGKEE----------------------------
---ASLEAMRRGTFESTPGIKEG-----KISGSWFWTEE-AKVGAGSQT-IETGSETEEE
AIFQSLIWAAKK-----DNVRAGVNRVSKPEN----------------------------
----------------------------EKGPNVEVRSSAKDEVINKAGSGDNCESNA--
-EAENIVGSWFWEGDEASFES-NPTPVFKAVCKPKSSAEQEPDPSRRPQSWDEVTVQFKP
-GPW----GKAGFPSISPFRFPKEA-ACLFAEMFGGKPKQEGEEESS------------C
---Q--SENGFPFQYDPSY--------------------RSVREIREHLKVRESADPESW
SCSCIQ-----CELNIGSEEFEELLLLMDRNRDPFIHEISKIAMGMRSASQFTR------
----------DFIRNSGVVSLIEALLNYPSTRV------RT-RFLEDMVSM-APPYPDLN
VIQTYVCQVCEDTFDYDLDSPEQLSGLSMITHLSATSDYHKVVGKYLAGF-FYLLNSGNT
K-TR-FHVLKLLLNLSENLIMTKRLLATE---SMSEFMTLFSKEDSN----------DNI
QIVLAIFDKISKNIQKEALFADDDD---EEEEVVVNL--DPLI-SAFHEIENFAKTLKRK
PDN---------------------------------------------------------
-------------------------------------------

------------------------------------------------------------
--------------------------------------------MGRTQEVGWVTAGLVI
WAGTCYYIYKFTKGRAQSVRTLARNGSTV-KMETVVG----VQSQTLAKSEAE----IKT
KPQAEIGAETGTRGGPGAEVETKGTAIARHRANSQ----AKTMVEAEAETQSE-------
SKVVAGTLVMTEAVTLTEVK--AKAREVAMKEAVTQTDAEAGKIVKKEAVTQTK-AKAWA
LIAKTEAKREAMTQTKAETHILAEKETEINRVMVTQSETLAVPKE----VVKMGATNKTG
IVDETKTRALEETVSVAKTQSEAWPGATVDARGNPNGMSREVAGVDVKSCAQSQAVTKIK
GDDMPGAGIEDMGNCK---------------------------TMSRAESGEDTRASAQP
QIVAKTQTEAIPGAKVDAGNNANAMCKVGAGADVRACV-QPQTVVKKQAEVTSGAG-VDG
RGNTNVISKAITGADMRAAAQPQAVASAQAEAMSDAKVKDRGNPNAMTKAGARANLRANS
QVEALPDARDKSRGNPNVIAKAGDGTDMLSCT-QPQLVASVQANTLSDGRIKVKGNVNTM
PKEGAGVDMKAQ--GMAQSQ-EALPNTRGKARGKAKAKCKTGSGMDMKTCTQPQTGVKTP
AEALLDSRVDGRGNPNATSKAGTKADQRACGQPLVVANPQGEALPGAKNKVKGNPHAVLK
VGAGEGTADSAQPQAV---------------------------------------VSFQG
EALLGTKNKVKGNPNVVLKAEVGAGAMGTAQLQIEASSKGEALLDSKNTVKGNSNAVSKA
GAGTDTTGSVQPQIVANSQGEVLPGAKNKFRGNSTTVPNSGVGPYT--------------
--------------------------TDSAQPQAVANSQGEVLPGAKNKVKANLNALSKA
EAGMGAT-----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------GSVQSQAVANAHCETLPGAKNK
VRGNWNAVSKAGAGMDTRGSAQTQAVANSQGEVLPGARNKVKGNPNVVSKAGAKEDTVGS
AQPQVVANSQRETLPGARNKVKGNPNVVSK-----AGAKEDTMGSAQPQVVANSQRETLP
GARNKAKGNSNAISKAEAGAGIMGSVQVQVVASSQGEVLPAAKNKVRGN--SNAVPKAEA
GADTVGSAQPQAVANSQSETLLGARNKVKGSTNTVPKAGTGAGTRHSAQPQIVAGSQ---
-------------------------------------GETLPGARDKAMPSSEAETTAED
EVYAKPE--AQAMPISESEGGSGTQACRKTQLNIHDYYWNGIGVEDWIAAERWIKFRFQT
MDGDWENSVSWADDENEASIGSWSGA-SDK--AGIIRSWAMAC----DEASVKSWAGARA
ENEVGIGTWARAG-EQASGGLWAGGQPSEGTWAGD------------KASGGAWTGAENQ
ASGGSWVLAGNQAIGELWAVGQASNGSWPGGQASGVSWVGAEAIGGSWTG--------AE
NQASGGSWAGA------------------------GAGNMSSVSYWAGVVDQASG-GSWA
GT------------SDQSGGGSKPRFEDQASGEGSWAGAGDQASGGSRLGPEDQSSGRSW
ADTADQASGGSRLGHVDQSSGG--------------------------------------
----------SWAGTLDQSGGGSKPIFENQTTEEG-SWAGAGGQAGGGSKVGSEDQSSGR
SWANSGDQISGGFLVGVVDQANGGSWTGA----GHPASGGPKPIFEDQASGRGSWA-DAG
DQVVGDSRLGLRDQSSGDSWAGTGDQASG------------WF-------------CVCP
G---SQ-TNGGSWGG---------------------------------------------
----------------------------PGSEDQS--SGIGSWGVAGGQVL---------
------------------------------------GGARP--ADQSSGGSWAGTG---N
QVSGRSWIGPG--NQ-AGDCSKPEFEDQ-ACGGSSWAGAGSQASGESWAGSTPGNE----
---ATGG-----S--RM-----------------GSE-----------------------
--------------------------DQATGGSWARSEDQASGRFQVTD-----------
-----------------------------------VAGEEAIICSRTEAE------NKAS
SGSWIRSEEVA--------YMGSCVGAEAEAEA--------------GAEAGAEAE--AG
AE----------------ALA-----ETEAEAG--------AEAGARAGAEAGAGAEAEA
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------GTGAEAEARAEA
EA----------------------------------------------------------
------------G------AG-----AEAEA------------------RAGAEA-----
EAEAEARAGAEAEA--------------EAE-----------------------------
------------------------------------------------------------
------------------------------------------------------------
-AEAEAEAGARAEAEA-----------------------------GAGAGAEAGAGVWSW
DGDA------------------------TTVESRLGAGEEAGV-----------------
---ESWTLARD------V-GEDELSRESSP-DI-EEIS----------------------
-LRSLFWAESENSNTFRSK--------SGKD--ANFDSGAGDNT-SIEDKFEA-------
-AGGVDIGSWFCDGNENTNED-KSASKAKAKKSSE-S----------RGTYPSM-VPGAG
MGSW----DGAMIWSETK--FP------------HQ--SEASFPVED----E-----SR-
KQ-T-----------------------------------RT------------GEKPRPW
SCRCKR------EANMDPRDLEKLICMIEMTEDPSVHEIANNALYNSADYPYSH------
----------EAVRNVGGISVIESLLNNPYPSV------RQ-KALNALNNI-SVAAENHR
KVKTYLNQVCEDTVTYPLNSNVQLAGLRLIRHLTITSEYQHMVTNYISEF-LRLLTVGSG
E-TK-DHVLGMLLNFSKNPSMTKDLLIAS---APTSLINIFSKKETK----------ENI
LNALSLFENINYHFKRRAKAFTQ--------DK-FSK--NSLY-FLFQRPKACAKKLRAL
AAECNDPEVKERVELLISKL----------------------------------------
-------------------------------------------

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---------------------------------MGGPRGAGWVAAG----------LLLG
AGACYCIYRLT--GGRRR-GDR---------ELGIRP--SK-------------------
------------------------------------------PAGGS-------------
------------------------------------------------------------
--A----------------G--------FPAGG---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------TS-------------------------------
------------------EGQ-L----CGRS--------------AR---------P-QR
GG---------------TWESQ------------WSKTSQ--------------------
-----------PE--------------------------------------------DLT
VGSYD--------DVLNAEQLQKLLYLLESTEDPVIIERALITLGNNAAFSVNQ------
----------AIIRELGGIPIVGNKINHSNQSV------KE-KALNALNNL-SVNVENQI
KIKIHINQVCEDVFSGPLNSAVQLAGLRLLTNMTVTNDHQHMLHSYITDL-FQVLLTGNG
N-TK-VQVLKLLLNLSENPAMTEGLLRAQ---VDSSFLSLYDSHVAK----------EIL
LRVLTLFQNINNCLKIEGHLAV---------QPTFTE--GSLFFLLHGE--ECAQKIRAL
V-DHHDAEVKEKVVTIIPKV----------------------------------------
-------------------------------------------

------------------------------------------------------------
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---------CF-PDNENRSQG-KSRPKAQANMSAE-S----------RGTYSSV-VPGAG
MGSW----AGAMIWTEIN--FP------------YQ--NESCLPPED----E-----LR-
KQ-I-----------------------------------RA------------GEKIQPW
ACRCKR------EANMDPREFEKLICMIEMTEDPSIHEVANNALFNSSVYPCSQ------
----------EVVRNVGGISIIESLLNNPYPSV------RQ-RALNALNNI-SVAAENHR
EVKTYINRVCEDTITYPVNSSVQVAGLRLIKHLTITSEYQHMVTNYISEF-LRLLTVGSG
E-TK-DHILEMLLNFSKNPSMTKDLLIAN---APTSLINIFSKKETK----------ENI
LNALSLFENINYHFKKRAKVFTQ--------DQ-FSK--NSLY-FLFQRPKVCAKKLRVL
AAEYNDPEVKEKVELLISKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
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-----------------------------------------------MGRARE--MGWMA
AGLM----IGAGACYCMYKLAM------------GR--DSRNELED------EEENEWDD
EQDLDEEEADLWFDFTTMARPWSEDGDWNEPGAPGGTEDRHSGGGKANRA--HPIKQRPF
PYEHK--------NTWGAQSFKSFNCALDLTQGASIQGKKKFTEPTNAGFSLSH------
----------NVGRHLASLSVVGNRIPTTPHTV------RE-KALCVPENP-NTSIGNQG
QIKMYTHEVCRETAFRCCKSFLQQAGLSLLMSMTVINN---VLAKSVADLQLSLISEGSG
C-AK-VESLEPLMVLSEKPVLVGEALAAQ---TLFSFMLLYIRSGSR----------EML
VGALCP------------------------------------------------------
------------------------------------------------------------
-------------------------------------------

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------------------------------------------------------------
---------------------------------MSRVRDAGCVAAG----------IVIG
AGAWYCVYKYT--RGRDQ-KKRRLT----KPKNRV--VAGTGARARAGLRAGFTIDLGPE
FSPPTTVCTGAEDK-VQVETSAFDMAGAETVIPAS------SSTETQSEAGSLAQEVEGA
--GIGPKT-ELVVRAAVTSATAQLLGVAETP------------KALEGATMAGLTKVA--
------------------------------------------------------------
------------------------------------------------------------
-------------E----------------------------------------APSAAE
APRAT----------KPPGVA---MSPRA-------------------------------
-------------------------------------------AVPP----RAVV-----
------------------------------------------------------------
----------------------------L------PQ-----GTAVSTKATAATELVEAP
GVGAPTEVAERSGMTLG-------------------------------EAAGAPVSTT-P
AGAAI-----------TARAA-----------------E-VP------------------
----------------------GTSGSTR-------------------------------
-----------TA-----AVSKKASPGTHTGAIPKAGS--ATGA---VPKGGA-------
-----------KGGTRSRTGG-K----G--KS------------KKNKAEVDELGLGFRP
GD---------GAAAAAAASAN------------GGHAFLAEIPDS-----EEGESGWTD
TESDSDSEPETQRRGRG----------------------------KK----VVTMQKRPF
PYEID--------EILGVRDLRKVLALLQKSDDPFIQQVALLTLSNNANYSCNQ------
----------ETIRKLGGLPIIANMINKTDPHI------KE-KALMAMNNL-SENYENQG
RLQVYMNKVMDDIMASNLNSAVQVVGLKFLTNMTITSDYQHLLVNSIANF-FRLLSQGGG
K-IK-VEILKILSNFAENPDMLKKLLSTQ---VPSSFSSLYNSYVES----------EIL
INALTLFEIIYDNLRAEVFN-----------YREFNK--GSLFY-LCTTSGVCVKKIRAL
A-NHHDLLVKVKVIKLVNKF----------------------------------------
-------------------------------------------

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------------------------------------------------------------
---------------------------------MGRTREAGCVAAG----------VVIG
AGACYCVYKLT--WGRDE-NEKILD----EDEESTDT--S--------------------
----------------------------ETGVETV------KGAKANVGAGSGAKL-HGD
------------SKVK--------PEVSLGL------------EN--------CPGVKEK
VHS----------------G--------SHSGGGLE---AKA------------------
------------------------------------------------------------
-------KALFNM-----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------L-KE--------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------QASAKAGKGVRVGII---------------------------
-----------SG---------------------------------NRTLAPSLPCPGGR
GG---------GCHPTRSGSR-------------A--------------------GGRAS
GKSKGKARSKSTRAPA-T---------------------------TW----PVRRGKFNF
PYKID--------DILSAPDLQKVLNILERTNDPFIQEVALVTLGNNAAYSFNQ------
----------NAIRELGGVPIIAKLIKTKDPII------RE-KTYNALNNL-SVNAENQG
KIKTYISQVCDDTMVCRLDSAVQMAGLRLLTNMTVTNHYQHLLSYSFPDF-FALLFLGNH
F-TK-IQIMKLIINFTENPAMTRELVSCK---VPSELISLFNKEWDR----------EIL
LNILTLFENINDNIKSEGLASS---------RKEFSR--SSLFF-LFKESGVCVKKIKAL
A-NHNDLVVKVKVLKVLTKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
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----MAGIPSQWILYCEMPWTWGLQTILARP---PGFNSQPPPKQ---II--QIKMNHLF
PNENK-------KFSGYAQNCKNGGCVLDLAKCLFIQGKLLFAEIKEEAFPFSQ------
----------NINSHLASLSMVRHTIPTPDPAV------RE--ALCAPDNL-NASIESQG
QIKMYIDEVCRETVSRCCNSFLQQAALNLLISMTVINN---MLAKSVSDLKFPLISEESG
C-AK-VQVLRPLMGLSEKPVLAGELVGAQ---MLFSFMSLFIRNGNR----------EIL
LETPAL------------------------------------------------------
------------------------------------------------------------
-------------------------------------------

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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------MTGAPQ-----TPRPAPASASRRCPGNRGAGRARPRSPPPPP
PRAAGSRREPRRAAG-RGGGPEPG-----RERGEAHLWTGTASPS----ESPR---CARS
LRLLAELRPSSAPSLRPRPRSAPA-APPGRSGRSGRS--------LRVSRAVSGR-----
-RGSGPISCV--------------------------------------------LPAPG-
LRRDPRL---P-ASRARPSAA-PR-----PQGSMGGARDVGWVAAG----------LVLG
AGACYYIYKLA--RGRRR-GAR---------GLRLRP--SR-------------------
------------------------------------------SAE---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------DLT
NGSYD--------DVLNVDQLQKLLYLLESTDDPVIIERALVTLGNNAAFSANQ------
----------VIIRELGGIPIIGSKINNPNHSI------KE-KALNALNNL-SVNVENQV
KIKVYINQVCKDVLSGPLDSAVQLAGLRLLTNMTVTNDHQHMLTDYVTDL-FHVLLTGDG
S-TK-VQVLKLLVNLSENPAMTEVLLGAQ---VDSSFVSLYDGHVAK----------EIL
LRVLTLSQNINNCLEK-GSLAV---------QPTFPK--GSLFFLLYGE--ECAQKMRAL
A-KHHDADVKEKIDV---------------------------------------------
-------------------------------------------

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---------------------------------------MTGTKN--KPRAQSA------
-TQARAGEDREATGV------VRPV---------------------AKTWAKAKEKPGSL
-----TDAV---------------------------------------------------
------AEMKAV-------------SKNKVIAEMKEGALSEPKALGKAI-----------
-----GDF----------------------------SPKAGNESSSSTCENGAGIDAWVW
AEEE------------------------ATM-------KEAGN-HSGA------------
---------KNDKP--------EIGAQVSA----E-------------------------
------------ELEPVAGASCKPRSGAEE------------------------------
EEEENVIGNWFWEGDDTSFDP-NPKPVSRIVRPQP---VEEIN---------EKKKKKKS
ARTPCCNSSSVRVRS-QASEASPPS----YIVLGSAEEISYSWPVA-------TACPSRN
TCSCSQPVPE------------------------------------------EVNGIKPF
ACPCKM------ECYS--------------TTDPLVHKRAQIAMGITLNPP---------
-----------------------------------------------------SGDERQH
KIELHVKHMCKDTTSFPLNSSGQQSRLTILGQLTTDFVHHYIVASDFSEL-FHLPSSGKY
K-AR-NLVLKVILNMSENPTAARDTINMK---ALAASKLIFNHKEAK----------TNL
VSSVAIFINIKEHIRKVSVVVVD----------HLSY--NTLM-GIFREVKGIIETM---
------------------------------------------------------------
-------------------------------------------

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---------------------------------RGGTRAGLKSR--------ISGP----
------ANTRAKAKIQDKAVA-----EAEPKTQPV----TQAKARNGAVARTQTVTYTEA
--VAMTKEVSKM------------------------------------------------
------------------------------------------------------------
-----------EAMTKTRVMAEAKAKPLA-EPDIVPQTKSKFTPMS----SAVTKCEVKA
G-----------------------------------------------------------
-------VGSEANIRSFAKAG-----DKANNESRPQR-----------------------
--------RREATLKFR----------AG-------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------DG---------------------------------------ADDEENVCSWFW
SGEE------------------------PSVGSWFWPEEETPSQV---------------
-----YKPLPK---------------------I-QEKP----------------------
------------------------------------------------------------
----------------------KPT--PK----------------------PELTIKQKA
-AAW----SRA--RYSVLVPIE------------GG--ERS-LPP---------EGNWTL
VETLIET--------PLGIRPLTKIPPYNGPYFQTLAE------IKKQVRYREKYGPNPR
ACRCKS-----RDFSLEPKEFDKLVALLKLTKDPFIHEIATMIMGISPAYPFTQ------
----------DIIHDVGITVMIENFVNNPNVKE------RP-RALNMVDDS-SESSEEPN
TEKSYIRQVCKDIISYPLNSPVQLAGLKLLVHLSVKFEDHHLIANYIPDF-LILLNKGSV
K-TK-FYVLKVFLRLSKNQANTRELISAK---VLSSLVAPFNKNESK----------ANI
LNIIEIFENINFQFKKKVKLFTK--------EE-FTK--SELI-SIFQEAKEFGRKLQDL
A-EHSDPEVRDKVIRLILKL----------------------------------------
-------------------------------------------

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-------------MICRLDSAVQMAGLRLLTNMTVTNHYQHLLSYSFPDF-FALLFLGNH
F-TK-IQTMKLIINFTENPAMTRELVSCK---VPSELISLFNKGWDR----------EIL
LNILTLFENINDNIKSEGLASS---------RKEFSR--SSLFF-LFKESGVCVKKIRAL
A-NHSDLVVKVKVLKVLTKL----------------------------------------
-------------------------------------------

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------------------------------------------------------------
---------------------------------MGRTREAGCVAAG----------VVIG
AGACYCVYRLA--WGRDE-NEKIWD----EDEESTDT--SE-------------------
-----------------------------TGVETV------KGAKTNVGAGSGAKLQGDS
-----------------------------KV------------KPEVSLGLEDCPGVKEK
AHS----------------G--------SHSGGGLE---AKA------------------
-----------------KALFNT-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------L----------------------------------
----------------KEQASAKAGKGARVGTIS--------------------------
---------------------------------------------GNRTLAPSLPCPGGR
GG---------GCHPTRSGSRA---------------------------------GSRAS
GKSKGKARSKSTRAPA-T---------------------------TW----PVRRGKFNF
PYKID--------DILSAPDLQKVLNILERTNDPFIQEVALVTLGNNAAYSFNQ------
----------NAIRELGGVPIIAKLIKTKDPII------RE-KTYNALNNL-SVNAENQG
KIKTYISQVCDDTMVCRLDSAVQMAGLRLLTNMTVTNHYQHLLSYSFPDF-FALLFLGNH
F-TK-IQTMKLIINFTENPAMTRELVSCK---VPSELISLFNKEWDR----------EIL
LNILTLFENINDNIKNEGLASS---------RKEFSR--SSLFF-LFKESGVCVKKIKAL
A-NHNDLVVKVKVLKVLTKL----------------------------------------
-------------------------------------------

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-------------HSKRYLL-------TGKS----FEIMVGRG-----------------
--------------------------------------------------FSATVRSLLG
MAI------GAGICYCAYRML-------------FA--RQRKKKHRD----KKGA--SR-
----------------------------------------T-------RE--KVPGRDLH
GALTKPENVSASVSDLQPHHLANLLDILVTSSDSSLQEKVLITLCNSAAFSANH------
----------DIIRSLGGITIIAKSLSDSSEQI------KV-NALNALNNL-SMNVQNQE
LIKDYINQTCSAISLSSLNSEVQLAGLRLIINMSVTDNYHNMVADHLPCF-LYLLAEGNN
IIQQ-IYTLKVLVNLSANPTMTQTLLTAK---GSQSLTSLFDSRVDR----------EIL
VRVLIFAANLSKHLGSGHGYDLH--------AN-YNE--DCLFNLLYGDSSPLQKDITAL
F-QYPDVEVKEQVVSLLINLARLRQL----------------------------------
-------------------------------------------

------------------------------------------------------------
--------------------------------------------MGRVQDVGWATAGLVI
WAGTCYCIYRLTKGRTQSVSGHARNGSRI-ETETVVG----EQNQTLATSEAMAGREAET
RVK--TEPETGEGGEPVAEVDSKVPVLVRSSGNCQ----AKTMLEEEIETRSE-------
TSSLVETMVMTEAVTLTEST--SQAKEVTMKEAVTQTDAEAEAVGKKEAVTQTK-AKAWA
MAGRAEVKKEAMTQTKAEARTLAEKETEINRVTVTQSEVLAVTKE----VVKIGTMNETG
VVAEAMIRPLEETVSVTRTQSETRLDAAVDTKENLNDMSVVVTGVDTKSCAQSQAVAIIQ
NDDMAGAEAD-KEDLK---------------------------NMSKAGSGVDMKAPGQP
HIAANNLAEAVPGAKNDAWDNAKDICEAE--ADIRTCLIESETVAKIETEATSSAT-MDG
GKDAN--AKAMTDINVTD-TQPQAVTSDQTEAMPDAKVKGKGNASAMAKAGAKANTKTSS
QTDALPDAGDKNRSDNNVTAKAETGIDMVSCT-QTEPVA--------------KDNANTT
SKEGAQA--------TGQSQGEALPNTKGKARGKAKAKCKAAAGTDTKTCAQPQAGTKTQ
AEALSDSKVDSKSDSNGVSKAGAKADQKASGQPQPVVNCQNEALPGTKNKVKGNPNPTPK
TEVGTATTSSAQT-----------------------------------------------
------------------------------------------------------------
------------NVT-SSQGETTPGAKNKAKGNRNSVPKAGAGPDT--------------
--------------------------TGSAQSQTIANSHSEALPGAKNKVKSNSNVVPKA
EAGVGTCPQSV-------------------------------------------------
------------------------------------------------------------
--------------------------AASQGTALTGTKTKVKGNSSAVSKPDAGAGTM--
------------------------------------------------------------
----------------------------------------------------------GS
AHAKTAANSQGETLPGSKNKVKGNSNAVPKAE-----AGAGTTEPNQPQ------AEALL
GARNKVKGNSNSVPKAESGASTILA-----LASSQAEALLGARNKVRGS--SNAAPKAEA
GVGARGSAQSQAVVSSQNEALLGARNKIRSNA--GTKSGARTGTRGSAQPQAVVSSQNEA
LLGARDKG----------------------------------------LSSSQVEATGDN
RVYAKPM--VGAVPASEMVTVA------GAQPNVHDYYWNGIGVEDWIAAERWIKFRFQT
IDGDWENSVSWTEDESGATIGPWTGAANDK--AGLVSSWAVAC----DETSIKSWTGARP
ENEVALGSWVSAG-DQATGAIWAGAQTTDGTWVAD------------KASAGSWTGAENQ
ISAGSWVVSGNQAIAGPWAVSQVTDGSWPAVQASGVSWVVDQATG-TWTV--------AE
NQTGAVSWAGA--------------------------GNIVSIGYWTGAVDQTNA-VSWT
GT------------TDQVGVEVKPRFEDQTSEKGSWVVAGVQTSGETRLGSEDQSSGRSW
TETVDQANAASRLGTVDQAGGTSWAGTGDQVGGVSTSGSADQSNSGSWAGTRNL------
------AGERSWTGTGDQSDGAAKPGFENQTSDEG-SWAGTIGQPSGGSKSVSEAQSAGR
SWADSADQLSGGFLVGPLDQANGESQPVS----GELAASG-----VDQTSGGGCWT-GSG
DQSGGESRLGPRDQSNGESWPGTGDQTGG------------WY-------------CTYT
G---TQTIGGGPWVGVSGQDVGGPKPVHMNQATGGAWLGTGTQVSAVSWTGD----QV-G
CSKPGFEDQAIGGGFWAGAGDQTTGGSRPAVSED-QSSGGVSWGGAGGHVI---------
------------------------------------GGSR---TDQSSGTSWPGMG---S
QVSGGSWIGSV--DQ-TSGCTKSGFEDQ-TCAGGSWVGTGEQTSGDSWPGSRASNE----
---ASGG-----S--RL-----------------DPQ-----------------------
--------------------------DQASGGSWMRSEDQASGRFLVSAEVEANEGFWFG
PGSEAFIGSWCWTED-ATILPVAGMKDEASTESTSGTREETSISSGLGDE------KKTG
PESWTRSEEAA--------FTGTCDGGEAKTVAGAEAEADPESKTRAEAKAEAEAE--TK
VEAE------VRVETR--AEA-----GAAATTA--------SEAGAEAGARVEAG-----
------------------------------------------------------------
-------------------------------------------------------AGAEA
GMGFWPWNG-DDTTKGSRLGAEAEAGAGGG---------------------------AEA
GAETENSMGFWFWNGD--AAT------KG------SKLGTEAEAE--TGIGTGTGTG--T
GTGTGTGTGTGVGAGVEVQAV-----ADTSMGFWFWDGAGAGAT--KGSRLGTEA-----
--EAGVGAGAQAGA--E----------AVGGTS-MEFWSWDGDEATKGSRLGAEAEPG--
------------------------T--------------------------------G--
------------------------------------------------------------
---------------V-----------------------------VAEPGAETSMGFWFW
NEDS------------------------TTKGSALGTEVGAGL-----------------
---GSWTFSTNVNDGEDEEEEDELSRESSP-GI-EEIS----------------------
-LRTLFGAESEDSNDLRST--------NEKD--VNSESGTGDKADDTKDQFDA-------
-ANGVDIRSWFYTGNENKCED-ESSSQVKVKKSTE-S----------RGIYPSM-VPGAG
MGVW----DGTIVCSESK--LL------------HK----TSFPGED----G-----FR-
RQ-V-----------------------------------ST------------GVKVHSC
NCRCKR------TVNLDPHDLEKLICMIEMTEDPSVHEIATNALYNSADYPYPQ------
----------EIDRNIGGISVIQSLLSNPYPNV------RQ-KALNALNNI-SVAAENHR
TVKTYLSQVCEDTVTYPLNSNVQVAGLRLIKHLTITSEYQHMVTNYISEF-LRLLALGSG
E-TK-DHVLRMLVNFSKNPSMTRDLLIAN---APTALINIFSKKETK----------ENI
LNALLLFENINRHFKKRGKAYPQ--------DR-FSK--TSLY-FLFQRPKACAKKLRAL
AADCSDPEVKERVEVLINKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------S---AMPEN--KSGTHAKTRKG-A
GIKA--EAERETTDI------VKA-------------------------------KAGFE
-----TDAV---------------------------------------------------
------TETKAV-------------SEAKGATETKARALSEPTALVKGV-----------
-----AKA----------------------------MPRSWARSDGATHKDETDSDAWFW
AGEE------------------------ASIGSWYWNGEEAGGDQTNA------------
---------KVEGE-------IDTAPSVNV----EEV-----------------------
------------GIEVTTGASSKPSK-V--------------------------------
-----VIWKWFWDGDKISFDP-NPRPLYRTVKPWV---TCEIDERNRPKDWSEVTIWPNG
PAEIP---ASLASGYQVPSRTRPLS----CTAQSSAEKNTGSLPVA-------EAGLREG
TSICLQSIDAYPFDSETCT--------------------QAIEKIRGQIRIRELNGIRPF
PCPCKM------ECRLNSEDFEKLVSLLKSNADPVIHKIAQIAMGVIKVHPLAQ------
----------QLINEMGVLTVIESLLHFQFPDM-------TRKTEITL-NP-ISVEERQR
RSTLHVVHMCKETVSFPLNSPGQRSGLKELGQLSADRNHHFIVAAYLPEL-SRMLSLGNH
K-TR-NLVLKVLLNMSENPIAAGDMMNIE---VLSALKLIFHQKEAK----------ANL
VTAVAIFVNIKEHIRRGSIVVVN----------PVSY--NELK-AVFHEVKTIIEKL---
------------------------------------------------------------
-------------------------------------------

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------------------------------------S---AMSEN--KSGTHAKTRKG-A
GIKA--EAEREATGI------VKA-------------------------------KAGFE
-----TYAV---------------------------------------------------
------AERKGV-------------SEAKVVTETKARALSEPTALVKGV-----------
-----AKA----------------------------MPRSWARSAGATHKDETDTDAWFW
AGEE------------------------ASIGSWFWNREEAGGDQTNA------------
---------KDEGE-------TDIGASINT----EEL-----------------------
------------GIEAATGASWKPRP-V--------------------------------
-----VIWKWFWDGGKISFDP-NPRPLYRTVRPRV---TCEIDERNRPKDGSEVTVWPNG
PAEIP---ASLASGYQVPSRTRPLS----CTAQSSGEKNTGSLPAA-------EAGLREG
TSICLQSIDAYPFDSETCA--------------------QAVEKIRGQIRIRELNGIRPF
PCPCKM------ECRLNSEDFEKLVSLLKSNADPVIHKIAQIAMGIIKVHPLAQ------
----------ELINEMGVLTVIESLLHFRLPNV-------TRKTEITL-NP-ISVEERQR
RNIIHVVHMCKETVSFPLNSPGQRSGLKELGQLSADRNHHFIVAAYLPEL-SRMLSLGNH
K-TR-NLVLKVLLNMSENPIAARDMMNIE---VLSALKLIFHQKEAK----------ANL
VTAVAIFVNIKEHIRRGLIVVVN----------PVSY--NELK-AVFREAKTIIEKL---
------------------------------------------------------------
-------------------------------------------

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---------------------------------MGRTREAGCVAAG----------VVIG
AGACYCVYRLA--WGRDE-NEKIWD----EDEESTDT--SE-------------------
-----------------------------TGVETV------KGAKTNLGAGSGAKLQGDS
-----------------------------KV------------KPEVSLGLEDCLGVKEK
AHS----------------G--------SHSGGGLE---AKA------------------
-----------------KALFNT-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------L----------------------------------
----------------KEQASAKAGKGARVGTIS--------------------------
---------------------------------------------GNRTLAPSLPCPGGR
GG---------GCHPTRSGSRA---------------------------------GGRAS
GKSKGKARSKSTRAPA-T---------------------------TW----PVRRGKFNF
PYKID--------DILSAPDLQKVLNILERTNDPFIQEVALVTLGNNAAYSFNQ------
----------NAIRELGGVPIIAKLIKTKDPII------RE-KTYNALNNL-SVNAENQG
KIKTYISQVCDDTMVCRLDSAVQMAGLRLLTNMTVTNHYQHLLSYSFPDF-FALLFLGNH
F-TK-IQTMKLIINFTENPAMTRELVSCK---VPSELISLFNKEWDR----------EIL
LNILTLFENINDNIKNEGLASS---------RKEFSR--SSLFF-LFKESGVCVKKIKAL
A-NHNDLVVKVKVLKVLTKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
-------MTGAEVESSAQAKPEKKVGEEG--------IG-----------GAERENEVPL
VVRPKV--------------------------RPQTQVMAGAKPKTESKPVPGARSKTES
------TAIAGA------------R-----------------------------------
ISGARPKI----------------------------ESPVMAGARPKTD------GRAVG
GARPKT--EAKAIPGARPKDDA--------------L--------------AWSQTEFG-
-----AEALSQGDGASQSNAVTWPLVRTDS--GSVTKSKCLSDDSELVDVDSETFSRLQ-
-VQTLVQPWFVKG-QETN------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---GGSWCYPRPRNR-EDVSIESGFWSADETSAVSSLWGGEETSIRSWPREEA---NTRS
RHRAKHQ-----T--NLRSRPRSKQETYFDS-WSGSE-----------------------
-DEAGSPFCFWTGENTSNLF----------------------------------------
---------------------RPRVREETNARSKLRTKREDC--FESESE------DEFY
KESWFLSGE-A---------SSR-----FRPRDKEEPNNILKPR----------------
SQ----KDVKISNRAEQEPRY-----KEEVIIGSWFWAEKEA------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------SL
EAG------ASAICESESGAE-----EGAI------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------GGSLFWTEEKS
NLGA--------------------------------------------------------
-----------------------------------------------LAK-EARPES---
------------------------------------------------------------
------------------------------------------------------------
-EEEAIFGSWFWDRDEACFDL-NPNPVYRVNCRFGNSVE-EPDESNRPKSWDEVTVPYKR
--PY----RAIGFPPLTSFRIPEGSY-----EAVEGKPNNMELSQEG----E--EDDFLF
EPGQ--FDSVFPFQYDPSY--------------------RSVQEIREHLKIKESADPENW
SCSCIQ-----CELKIGAVEFEELLLLMDRIRDPFIQEISKIAMGMRTASQFTR------
----------DFIRDSGIVSLIETLLNYPSSRV------RT-SFLENMVHM-APPYPNLN
MIETFICQVCEETLAHSVNSVEQLTGIMMLRHLTMTPDYHTLVANYMSGF-LTLLTTGNA
R-IK-FHVLKMLLNLSENLKVAKNLFSAK---ALSVFVGLFNIEETN----------DNI
QIVIKMFQNISNIIRSGAMAFID---------DDFSL--EPLI-SAFHEFEELAKQLQVQ
IDNQNDPEVGQQ------------------------------------------------
-------------------------------------------

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------------------------------------ILAALIALGNNAAYAFNR------
----------DIIRDLGGLPIVAKILNTRDPIV------KE-KALIVLNNL-SVNTENQR
RLKIYMNQVCDDTVTSRLNSSVQLAGLRLLTNMTVTNEYQHMLANSISDF-FRLFSAGNE
E-TR-LQVLKLLLNLAENPAMARDLFRAQ---VPSSLSSLFNKKENK----------DII
LKLLIIFENVIDNFKWDETDLT---------QNQFEE--GSLFS-FLKDFQVCADKVLGI
E-SHHDFLAKVRVGKFMAKLAERMFPKGQE------------------------------
-------------------------------------------

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-----RARGKSTRTPS-T---------------------------SW----PVRRGKFNF
PYKID--------DILGATDLQRVLNILERTNDPFIQEVALVTLGNNAAYSFNQ------
----------NAIRELGGLPIIAKMIKTKDPII------RE-KAYNALNNL-SVNAENQG
KIKAYISQVCDDTMICRVDSAVQMAGLRLLTNMTVTNHYQHLLSYSFPDF-FALLFLGNY
F-TK-IQTMKLIINFTENPAMTKELVSCK---VPSELISLFNKEWDR----------EIL
LNILTIFENVNDNINSEGLASS---------RKEFSR--SSLFF-LFKESGVCVKKIKAL
A-NHSDLVVKVKVLKVLTKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
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---------------------------------MIGVRHASWVAAG----------LVLG
AGACYGIYLPPLRRGGRQ-TEESAG----RRGR---A--GA-------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------V--------AP----PG---EG-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------TR-------------------------------
---------------------------------------------RG---------AYEG
RG---------------AWKSR------------WSSPS---------------------
--------------QA-------------------------------------E---DLT
SGSHD--------DVLNASQLQKLLYLLESTEDPVITERALVTLGNSAAFSANQ------
----------AIIRELGGIPVVGNKLNNPNQSI------KE-KALNALNNL-SVNVENQV
KIKMYIHQVCEDVLSGPLNSAVQLAGLRLLTNMTVTNDHQHMLSSYITDL-FHVLLAGNG
H-TK-VQVLKLIVNLSENPAMTEGLLTAQ---VDSSFLALYDGHVAK----------EIL
LRVLTLFQNINNCLKTGGRLAV---------RPPSPQ--GSLSLLLYGE--ECAQKMRAL
A-SHQDADVQEKAVTIIPEF----------------------------------------
-------------------------------------------

------------------------------------------------------------
--------------------------------------------MGRTQEVGWVTAGLVI
WAGTCYYIYKFTKGRAQSVRTLARNGSTV-KMETVVG----VQSQTLAKSEAE----IKT
KPQAEIGAETGTRGGPGAEVETKATAIARHRANSQ----AKTMVEAEAETQSE-------
SKVVAGTLVMTEAVTLTEVK--AKAREVAMKEAVTQTDAEAGKIVKKEAVTQTK-AKAWA
LIAKTEAKREAMTQTKAETHILAEKETEINRVMVTQSETLAVPKE----VVKMGATNKTG
IVDETKTRALEETVSVAKTQSEARPGATVDARGNPNGMSREVAGVDMKSCAQSQAVTKIK
GDDMPGAGIEDMGNCK---------------------------TMSRAESGADTRASAQP
QIVAKTQTEAIPGAKVDAGNNANAMCKVGAGADVRACV-QPQTVVKKQAEVTSGAG-VDG
RGNTNVISKVITGADMRAAAQPQAVASAHAEAMSDAKVKDRGNPNAMTKAGARANLRTNS
QVEALPDARDKSRGNPNVIAKAGDGTDMLSCT-QPQLVASVQANTLSDGRIKVKGNVNTM
PKEGAGVDMKAQ--GMAQSQGEALPNTRGKARGKAKAKCKTGSGMDMKTCTQPQTGVKTP
AEALLDSRVDGRGNPNATSKAGTKADQRACGQPLVVANPQGEALPGAKNKVKGNPHAVLK
VGAGEGTADSAQPQAV---------------------------------------VSFQG
EALLGTKNKVKGNPNVVLKAEVGAGAMGTAQLQIEASSKGEALLDSKNTVKGNSNAVSKA
GAGTDTTGSVQPQIVANSQGEVLPGAKNKFRGNSTTVPNSGVGPYT--------------
--------------------------TDSAQPQAVANSQGEVLPGAKNKVKANLNALSKA
EAGMGAT-----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------GSVQSQAVANAHCETLPGAKNK
VRGNWNAVSKAGAGMDTRGSAQTQAVANSQGEVLPGARNKVKGNPNVVSKAGAKEDTMGS
AQPQVVANSQRETLPGARNKAKGNSNAISKAEAGKAGAKEDTMGSAQPQVVANSQRETLP
GARNKAKGNSNAISKAEAGAGIMGSVQVQVVASSQGEVLPAAKNKVRGN--SNAVPKAEA
GADTVGSAQPQAVANSQSETLLGARNKVKGSTNTVPKAGTGAGTRHSAQPQIVAGSQ---
-------------------------------------GETLPGARDKAMPSSEAETTEED
EVYAKPE--AQAMPISESEGGSGTQACRKTQLNIHDYYWNGIGVEDWIAAERWIKFRFQT
MDGDWENSVSWADDENEASIGSWSGA-SDK--AGIIRSWAVAC----DEASVKSWAGARA
ENEVGIGTWARAG-EQASGGLWAGGQPSEGTWAGD------------KASGGAWTGAENQ
ASGGSWVLAGNQAIGELWAVGQASNGSWPGGQASGVSWVGAEAIGGSWTG--------AE
NQASGGSWAGA------------------------GAGNMSSVSYWAGVVDQASG-GSWA
GT------------SDQSGGGSKPRFEDQASGEGSWAGAGDQASGGSRLGPEDQSSGRSW
ADTADQASGGSRLGHVDQSSGG--------------------------------------
----------SWAGTLDQSGGGSKPIFENQTTEEG-SWAGAGGQAGGGSKVGSEDQSSGR
SWANSGDQISGGFLVGVVDQANGGSWTGA----GHPASGGPKPIFEDQASGRGSWA-DAG
DQVVGDSRLGLRDQSNGDSWAGTGDQASG------------WF-------------CVCP
G---SQ-TNGGSWGGASGQDVGGSRPGPTNQSSAGSWDSPGSQVSGSSWTGAGAVDQVGG
CSKPGFEDQAIGGGFWPGPGDQTGGGSRPGSEDQS--SGIGSWGMAGGQVL---------
------------------------------------GGARP--ADQSSGGSWAGTG---N
QVSGRSWIGPG--NQ-AGDCSKPEFEDQ-ACGGSSWAGAGSKASGESWAGSTPGNE----
---ATGG-----S--RM-----------------GSE-----------------------
--------------------------DQATGGSWARSEDQASGRFQVSVEVEANEGFWFG
PGAEAVIGSWCWTEAKADIVSKPDDKDEATTASRSEAGEEAIICSRTEAE------NKAS
SGSWIRSEEVA--------YMGSCVGAEAEAE------------------A--EAG--AE
AG----------------AE----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-AEAGAEAGAEAGAGA-----------------------------GAGAGAEAGAGVWSW
DGDA------------------------TTVESRLGAGEEAGV-----------------
---ESWTLARD------V-GEDELSRESSP-DI-EEIS----------------------
-LRSLFWAESENSNTFRSK--------SGKD--ANFDSGAGDNT-SIEDKFEA-------
-AGGVDIGSWFCDGNENTNED-KSASQAKAKKSSE-S----------RGTYPSM-VPGAG
MGSW----DGAMIWSETK--FP------------HQ--SEASFPVED----E-----SR-
KQ-T-----------------------------------RT------------GEKPRPW
SCRCKR------EANMDPRDLEKLICMIEMTEDPSVHEIANNALYNSADYPYSH------
----------EAVRNVGGISVIESLLNNPYPSV------RQ-KALNALNNI-SVAAENHR
KVKTYLNQVCEDTVTYPLNSNVQLAGLRLIRHLTITSEYQHMVTNYISEF-LRLLTVGSG
E-TK-DHVLGMLLNFSKNPSMTKDLLIAN---APTSLINIFSKKETK----------ENI
LNALSLFENINYHFKRRAKAFTQ--------DK-FSK--NSLY-FLFQRPKACAKKLRAL
AAECNDPEVKERVELLISKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
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--------------DSHLGHV--ENQVQDWIGLYNWASTMTGAEN--KIGEQAKTEKG-A
GVKAEDEAEREVTGI------VIPV---------------------VNTQAKAIAKAGSE
-----AVAI---------------------------------------------------
------VSKKAV-------------SKNRFVAEMKERALLEHEALPKAMCRSWVRSKEIN
TG---FSL----------------------------RAENEATMSRSTCKDEAGIDSWFW
SGEE------------------------ASIGSWFWNGEVAGN-RHSA------------
---------KYEDE-------IGTGASSCE----VGL-----------------------
------------GVEPAARVSCKPRPRAEE------------------------------
--EEDIIGNWFWDGDDTSFDP-NPRPVSRIIRPQP---VDEINEKNRPKSWSEVTIWPNA
PAVTP---AVLGFRSQVPFETRLPS----YVVLASAKESTHYMPSA-------SVRPSRN
ASSYTHSMPENPFGSDPCI--------------------QTIEEIRRQIRIRELNGIKPF
ACPCKM------ECCMDSEEFEKLVSLLKSTTDPLIHKIAQIAMGINNIHPFAQ------
----------EFINEVGVVTLIESLLSLPSPEM-------KKRVVITL-NS-PSRDERQH
KVELHVKHMCKETLLFPLNSPGQQSGLKTLGQLTTDSDHHYIVANYFSEL-FHLLSQGNC
K-TR-NLVLKVLLNMSENPVAARDMINIK---SLSVLKLIFNQREEK----------ANL
VSAMAILTNIKEHIRKRSNVVVD----------HLTY--NTLM-AIFREVKMIIETM---
------------------------------------------------------------
-------------------------------------------

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---------------------------------------MTGTKN--KTRAQAKTEKK-P
VTQAKAGAEREATGG------VRPV---------------------AKTRAKAKAKTGSK
-----TDAV---------------------------------------------------
------AEMKAV-------------SKNKVVAEVKEGALSEPKTLGRAM-----------
-----GDF----------------------------SSKAGNESTSSTCKNEAGIDAWFW
AGEE------------------------ATINSWFWNGEEAGN-SSST------------
---------KNDKP--------EIGAQVCA----E-------------------------
------------ELEPAAGADCKPKSGAEE------------------------------
EEEENVIGNWFWEGDDTSFDP-NPKPVSRIVKPQP---LYEINEKNRPKDWSEVTIWPNA
PAVTP---AVLGFRSQAPSEASPPS----YIVLASAEENACSLPGA------TACRPSRN
TRSCSQPIPECRFDSDPCI--------------------QTIDEIRRQIRIREVNGIKPF
ACPCKM------ECYMDSEEFEKLVSLLKSTTDPLIHKIARIAMGVHNVHPFAQ------
----------EFINEVGVVTLIESLLSFPSPEM-------RKKTVITL-NP-PSGDERQR
KIELHVKHMCKETVSFPLNSPGQQSGLKILGQLTTDFVHHYIVANYFSEL-FHLLSSGNC
K-TR-NLVLKLLLNMSENPTAARDMINMK---ALAALKLIFNQKEAK----------ANL
VSGVAIFINIKEHIRKGSIVVVD----------HLSY--NTLM-AIFREVKGIIETM---
------------------------------------------------------------
-------------------------------------------

------------------------------------------------------------
--------------------------------------------MGRIQEVGWVTAGLVI
WAGTCYYIYKFTKGRAQSVRTLARNGSTV-KMETVVG----VQSQTLAINEAE----IKT
KPQVEIGAETGARSGPGAEVETKAAAIAIHRANSQ----AKAMVGAEPETQSE-------
SKVVAGTLVMTEAVTLTEVK--AKAREVAMKEAVTQTDAEAGKIVKKEAVTQTK-AKAWA
LVAKTEAKREAMTQTKAETHILAEKETEINRVMVTQSETLAAPRE----VAKMGATNKTG
IVDETKTRALEETVSVAKTQSEARPGATVDARGNLNGMSREVAGVDMKSCAQSQAVTKIQ
GDDMPGTGVEDMGNCK---------------------------TMSRAESGADTRASAQP
QIFAKTQTEAIPGAKIDAGGNTNAMCKVGAGADVRACI-QPQTVAKKQAEVTSGAR-VDG
RGNTNVISKAITGADMRAAAQPQAVASTHAEAMSDAKVKNRGNPNAMTKAGAKANLRANS
QVEALPDARDKSRGNPNAMAKVGDGTDMLSCT-QPQLVASVQADTLSDGKIKVRGNVNTM
PKEGAGVDMKAQ--GMAQSQGEALPNTRGKARGKAKAKCKTGPGMDMKTCTQPQAGVKTP
AEALLDSRVDGRGNPNATSKAGTKADQRVCGQSLVVANPQGEALPGAKNKVKGNPHTVLK
VGAGEGTTDSAQPEAV---------------------------------------VSFQG
EALLGTKNKVKGSPNVVLKAEVGAGAMGTAQLQIMASSKGEALLDSKNKVKGNSNAVSKA
GAGTDTTGSVQPQIVANSQGEVLPGAKNKVRGNPTTVPNSGVGPYT--------------
--------------------------TDCARPQAVANSQGEVLPGAKNKVKANLNAVSKA
EAGMGAT-----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------GSVQPQAVANSHCETLPGAKNK
VRGNWNAVSKAGAGMDTRGSAQPQAVANSQGEVLPGAKNKVKGNPNVVSKAGAREDTVGS
TQPQVLASSQRETLPGARNKVKGNSNVVSK-----AGAREDTMGSAQPQVVANSQRETLP
GARNKVKGNSNAISKAEAGAGIMGSVQVQVVASSQGEVLPGAKNKVRGN--SNAVPKAEA
GADTVGSAQLQAVANSQSETLLGARNKVKGNTIAVPKAGTGAGTRHSAQPQIVAGSQ---
-------------------------------------GETLPGARDKSMSTSEAEATAED
EAYAKPE--AEAMPTSESEGGSGTQACRKTQPNIHDYYWNGIGVEDWIAAERWIKFRFQT
MDGDWENSVSWADDENEASIGSWSGA-SDK--AGIIRSWAVAC----DETSVKSWAGARA
ENVVGIGTWARAG-EQASGGLWAGGQTSEGTWAGD------------KASGGAWTGAENQ
ASGGSWALTGNQAIGELWAAGQASDGSWPGGQASGVSWVGEEAIGGSWTG--------AE
NQASEGSWAGA------------------------GAGNMSSVSYWAGVVDQAGG-GSWA
GT------------SDQSGGGSKPRFEDQASGEGSWAGAGGQASGGSMLGPEDQSSGRSW
ADTADQASGGSRLGHVDQSSGG--------------------------------------
----------AWAGTLDQSGGGSKPRFENQTTEEG-SWAGAGGQAGGGSKVGPEDQSSGR
SWANSGDQISGGFLVGIVDQANGGSWTGA----GHPASVGPKPIFEDQVSGRGSWA-DAG
EQVVGDSRLGLRDQSSGDSWAGTGDQASG------------WF-------------CVCP
G---SQ-TNGGSWGGASGQDVGGSRPGPMNQSSAGSWDSTGSQVSGSCWTGAGAVDQAGG
CSKPGFEDQAIGGGFWPGAGDQTGGGSRPGSEDQS--SGIGSWGVAGGQVL---------
------------------------------------GGARPGPADQSSGGSWAGTG---N
QSSGRSWIGPG--DQ-AVDCSKPEFEDQ-ACGGGSWAGAGSQASGESWAGSRPGNE----
---AIGG-----S--RM-----------------GSE-----------------------
--------------------------DQATGGSWARSEDQASGRFQVSFEVEANEGFWFG
PGAEAVIGSWCWTEEKADIVSRPDDKDEATTASRSGAGEEAIICSRTEAE------NKAS
SGSWIRSEEVA--------YMGSCVGAEAGAGA--------------EAGAGAGAG----
---------------------------------------------AEAGAE---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------AGAEAGAEA-----------------------------GAGAGAESGAGVWSW
DGDA------------------------TTVESRLGAGEEAGV-----------------
---ESWTLARD------V-GEDELSRESSP-DI-EEIS----------------------
-LRSLFWAESENSNTFRSK--------SGKD--ANFESGAGDNT-SIKDKFEA-------
-AGGVDIGSWFCAGNENTSED-KSAPKAKAKKSSE-S----------RGIYPSM-VPGAG
MGSW----DGAMIWSETK--FA------------HQ--SEASFPVED----E-----SR-
KQ-T-----------------------------------RT------------GEKTRPW
SCRCKH------EANMDPRDLEKLICMIEMTEDPSVHEIANNALYNSADYSYSH------
----------EVVRNVGGISVIESLLNNPYPSV------RQ-KALNALNNI-SVAAENHR
KVKTYLNQVCEDTVTYPLNSNVQLAGLRLIRHLTITSEYQHMVTNYISEF-LRLLTVGSG
E-TK-DHVLGMLLNFSKNPSMTKDLLIAN---APTSLINIFSKKETK----------ENI
LNALSLFENINYHFKRRAKAFTQ--------DK-FSK--NSLY-FLFQRPKACAKKLRAL
AAECNDPEVKERVELLISKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
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-------MTGAETEPGTQVKSEKKTGEVVG--------D-----------GAERKVDVPL
VVRPKV--------------------------RIEAHVTTGVRPKTVAPVINGE------
------------------------------------------------------------
------------------------------------------------------------
--HPLS--EVEAIPGARPSDKA--------------P--------------AWSLTDFG-
-----AEAISKTKGKDPSNIKACPLFITDS--GPVAKTNTLFTDTELGNVETASFPGPKV
QSQGGIHPYFLSG-KESN------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---MESWCCPRTQFK-QEASNNFD-----NSSLGSWVWNIKELNNRFCPKDREKT-YKRY
RHRVKHE-----A--KTMSRTQTKRKLYIVS-SSGSE-----------------------
-DESVKMSCMWAKEKTKPWS--RAREEASSSRSMFRTKKEVFL------------ESSSG
SEGETHMKSWFWDREEAKSKLKPR--KEISIRSRHRAKRETCSNFMTGPV------EVIQ
KASWFWPKEKA---------NNL-----SKTKTKKKIRARSVAK----------------
EE----A------KAKQEARS-----EEEVLIGTWFWAAEEDSVV------ASPQSEDES
IFGNWFWTEE-ASMGTTASIKS-SQRAEEVAVVQCWFRSE-EKTSIENGSVTNSKFTPSD
EEE-EILVGSWFWARDA-AD---------------------------------QEAEEET
IFGSWFWVSDDAS-VKADVGASCE-------------------------------SSSK-
-S-KEGVIGSWFWTGE----------E----------ATPWAGEETTYGSWFGARDKISM
DSG------PEANCDTKTEVE----EEEPIVGSWFWAIVEASVDAGASSKSTLEDRED-D
IKPSWFQAREEVSMQSGTCNSCRPLAGAEEANNESCFWTVGDPCMHPANGESWKSGTEKE
-----EDAISSLFLSRKHAKPETIIG------------------------SLFWSRKESS
V-EGAGEEPRQLTE-KTMIQSCSC-TE-AAFIEATGKEESRPEVEEETTIGSWFWPGEED
SIEATAKAREQKRLVHEEE-VTDGSWFRAREEAIREKSGFCSKSSPEAEEEVAIIRSWFC
TEERA------------------------------------SLDAESQIREKTRSSTEEE
TIFAPWFWAGKE-----VTIETGTCCVSKQEDD-EEMV----------------------
-IESWFWSGDETIKETETVATCESRPENDKEEIVGSGFGVRDEVSNETGSGTNCESSLVA
E-EEAIVGSWFWEGDETHFES-NPMPVFRNICRSMCTVGEEPDPSRRPQSWEEVTVQFKP
-GPW----GRVGFPSTSFFRFSKEA-SSLFSEMFCGKPKHMELSPEG----E--EQESLL
QPDQ--PDPEFLFEYESSY--------------------RSVTEIREHLKAKESVEPESW
SCSCIQ-----CELRISSEEFEELLLLMDRIRDPFIHEISKIAMGTRSASQFTR------
----------DFIRDSGVVSLIETLLNYPSSRV------RN-SFLENMIRM-APPYPNLN
MIETYICQVCEETLAYSLDSLEQLSGLRMVGYLTTTTDYHTLVANYMSGF-LSLLATGNT
K-TR-YHALKMLLNLSENPVMTKELLSAE---AVSEFMGLCNN-ETN----------DNI
QIVLAMFENIGDHIKNEAMLFT---------DDDFSI--EPLI-SAFHEFEEYAKELQCK
RNSQNDSEAGQEN-----------------------------------------------
-------------------------------------------

MSATGRKITGSKETKRRLLLISRDW------------VYYQDKQEERRELPWIITGPPPV
AAVVAFEWLKTSTLTGLHPQLPLSLPQPKCALPYLVRAFSRGDYMGRTQEVGWVTAGLVI
WAGTCYYIYKFTKGRAQSVRTLARNGSRV-KMETVVG----VQSQTLAISEAE----IKT
KPQAEIGAETGTRGGPGAEVETKATAIARHRANSQ----AKTMVEAEAETQSE-------
SKVVAGTLVMTEAVTLTEVK--AKAREVAMKEAVTQTDAEAGKIVKKEAVTQTK-AKAWA
LIAKTEAKREAMTQTKAETHILAEKETEINRVMVTQSETLAVPKE----VVKMGATNKTG
IVDETKTRALEETVSVAKTQSEARPGATVDARGNPNGMSREVAGVDMKSCAQSQAVTKIK
GDDMPGAGIEDMGNCK---------------------------TMSRAESGADTRASAQP
QIVAKTQTEAIPGAKVDAGNNANAMCKVGARADVRACV-QPQTVVKKQAEVTSGAR-VDG
RGNTNVISKAITGADMRAAAQPQAVASAHAEAMSDAKVKDRGNPNAMTKEGARANLRANS
QVEALPDARDKSRGNPNVIAKAGDGTDMLSCT-QPQLVASVQANTLSDGRIKVKGNVNTM
PKEGAGVDMKAQ--GMAQSQGEALPNTRGKARGKAKAKCKTGSGMDMKTCTQPQTGVKTP
AEALLDSRVDGRGNPNATSKAGTKTDQRACGQPLVVANPQGEALPGAKNKVKGNPHAVLK
VGAGEGTADSAQPQAV---------------------------------------VSFQG
EALLGTKNKVKGNPNVVLKAEVGAGAMGTAQLQIEASSKGEALLDSKNTVKGNSNAVSKA
GAGTDTTGSVQPQIVANSQGEVLPGAKNKFRGNSTTVPNSGVGPYT--------------
--------------------------TDSAQPQAVASSQGEVLPGAKNKVKANLNALSKA
EAGMGAT-----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------GSVQSQAVANAHCETLPGAKNK
VRGNWNAVSKAGAGMDTRGSAQTQAVANSQGEVLPGARNKVKGNPNVVSKAGTKEDTMGS
AQPQVVANSQRETLPGARNKAKGNPNVVSK-----AGAKEDTLGSAQPQVVANSQRETLP
GARNKAKGNSNAISKAEAGAGIMGSVQVQVVASSQGEVLPGAKNKVRGN--SNAVPKAEA
GADTVGSAQPQAVANSQSETLLGARNKVKGSTNTVPKAGTGAGTRHSAQPQIVAGSQ---
-------------------------------------GETLPGTRDKALPSSEAETTAED
EVYAKPE--AEAMPISESEGGSGTQACRRTQLNIHDYYWNGIGVEDWIAAERWIKFRFQT
MDGDWENSVSWADDENEASIGTWSGA-SDK--AGIIRSWAVAC----DEASVKSWAGART
ENEVGIGTWARAG-EQASGGLWAGGQPSEGTWAGD------------KASGGAWTGAENQ
ASGCSWVLAGNQAIGELWAVGQASNGSWPGGQASGVSWVGEEAIGGSWTG--------AE
NQASGGSWTGA------------------------GAGNMSSVSYWAGVVDQASG-GSWA
GT------------SDQSGGGSKPRFEDQASGEGSWAGAGDQASGESRLGPEDQSSGRSW
ADTADQASGGSRLGHVDQSSGG--------------------------------------
----------SWAGTLDQSGGGSKPIFENQTTEEG-SWAGAGGQAGGGSKVGSEDQSSGR
SWANSGDQISGGFLVGVVDQANGGSWTGA----GHPASGGPKPIFEDQASGRGSWA-DAG
DQVVGDSRLGLRDQSSGDSWAGTGDQASG------------WF-------------CVCP
G---SQ-TNGGSWGGASGQDVGGSRPGPTNQSSAGSWDSPGNQVSGSSWTGAGAVDQVGG
CSKPGFEDQVIGGGFWPGPGDQTGGGSRPGSEDQS--SGIGSWGVAGGQVL---------
------------------------------------GGARP--ADQSSGGSWAGTG---N
QVSGRSWIGPG--NQ-AGDCSKPEFEDQ-ACGGSSWAGAGSQASGESWAGSTPGNE----
---ATGG-----S--RM-----------------GSE-----------------------
--------------------------DQATGGSWARSEDQASGRFQVSVEVEANEGFWFG
PGAEAVIGSWCWTEAKADIVSKPDDKDEATTASRSEAGEEAITCSRTEAE------NKAS
SGSWIRSEEVA--------YMGSCVGAEAEAE------------------AGAEAE--AG
AE----------------AVA-----EAEAXXX---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--XAEAEAEAEAEA--------------EAE-----------------------------
------------------------------------------------------------
------------------------------------------------------------
-AEAEAGAGARAEAEA-----------------------------GAGAGAEAGAGVWSW
DGDA------------------------TTVESRLGAGEEAGV-----------------
---ESWTLARD------L-GEDELSRESSP-DI-EEIS----------------------
-LRSLFWAESENSNTFRSK--------SGKD--ANFDSGAGDNT-SIKDKFEA-------
-AGGVDIGSWFCDGNENTNED-KSASKAKAKKSSE-S----------RGTYPSM-VPGAG
MGSW----DGAMIWSETK--FP------------HQ--SEASFPVED----E-----SR-
KQ-T-----------------------------------RT------------GEKPRPW
SCRCKR------EANMDPRDLEKLICMIEMTEDPSVHEIANNALYNSADYPYSH------
----------EAVRNVGGISVIESLLNNPYPSV------RQ-KALNALNNI-SVAAENHR
KVKTYLNQVCEDTVTYPLNSNVQLAGLRLIRHLTITSEYQHMVTNYISEF-LRLLTVGSG
E-TK-DHVLGMLLNFSKNPSMTKDLLIAN---APTSLINIFSKKETK----------ENI
LNALSLFENINYHFKRRAKAFTQ--------DK-FSK--NSLY-FLFQRPKACAKKLRAL
AAECNDPEVKERVELLISKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
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-----MRAVAA--WGRPP-G----------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
-------------------GEG---------------RA---------------------
--------------AA-------------------------------------E---DLT
NGSYD--------DILNAEQLQKLLYLLESTEDPMITERALVTLGNSAAFSTNQ------
----------AIIRELGGIPIIGIRINSPNQSI------KE-KALNALNNL-SVNADNQI
KIKVYVNQVCKDVLSGPLDSAVQLAGLRLLTNMTVTNEHQHMLNSYIADL-FHVLLTGNG
T-TK-VQVLKLLVNLSENPAMTEGLLSAQ---VDSSFLSLFDGHVPQ----------EIL
LRVLTLFQNINDCLRAGGHLAV---------QPPFPK--GALFSLLYGE--ECVQKMKAL
V-YHDDVDVREKVVTIIPKS----------------------------------------
-------------------------------------------

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-------MTGAEIEPSAQAKPEKKAGEEV--------IA-----------GAERENDVPL
VVRPKV--------------------------RTQ--ATTGARPKTETKSVPGARPKTDA
------QAMSGA------------RPKT----------------------------EAQV
MGGARPKT----------------------------EAQGMAGARPKTD------ARAVG
GARPKT--DAKAIPGTRPKDEA--------------Q--------------AWAQSEFG-
-----TEAVSQAEGVSQTNAVAWPLATAES--GSVNKSKGLSMDRELVDVDAETFPGTQ-
-GQKGIQPWFGPG-EETN------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---MGSWCYSRPRAR-EEASNESGFWSADETSTVSSFWAGEETSIRSWPREDS---NTRS
RHRAKHQ-----T--NPRSRPRSKQEAYVDS-WSGSE-----------------------
-DEAGNLFAFWAGENTSNLF----------------------------------------
---------------------RPRVREEANIRSKLRTNREDC--FESESE------DEFY
KQSWVLPGEEA---------NGR-----FRCRDKEDPNTALKPR----------------
AQ----KDV-DGDRVKQEPRF-----EEEVIIGSWFWAEKEA------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------SL
EGG------ASAICESEPGTE-----EGAI------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------GGSTYWAEEKS
SLGA--------------------------------------------------------
-----------------------------------------------VAREEAKPES---
------------------------------------------------------------
------------------------------------------------------------
-EEEAIFGSWFWDRDEACFDL-NPCPVYKVSDRFRDAA-EELNASSRPQTWEEVTVEFKP
-GLF----HGVGFRSTSPFRIPEEAS-----EILEAKPKNMELSPEG----E--EQESLL
QPNQ--PDPEFTFQYDPSY--------------------RSVREIREHLRARESAESEGW
SCSCIQ-----CELKIGSEEFEELLLLMDKIRDPFIHEISKIAMGMRSASQFTR------
----------DFIRDSGVVSLIETLLNYPSSRV------RT-SFLENMIHM-APPYPNLN
MIETFICQVCEETLAHSVDSLEQLTGIRMLRHLTMTIDYHTLIANYMSGF-LSLLTTANA
R-TK-FHVLKMLLNLSENPAVAKKLFSAK---ALSIFVGLFNIEETN----------DNI
QIVIKMFQNISNIIKSGKMSLID---------DDFSL--EPLI-SAFREFEELAKQLQAQ
IDNQNDPEVGQQS-----------------------------------------------
-------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------MTGAEIEPSAQAKPEKKAGEEV--------IA-----------GPERENDVPL
VVRPKV--------------------------RTQ--ATTGARPKTETKSVPAARPKTEA
------QAMSGA------------RPKT----------------------------EVQV
MGGARPKT----------------------------EAQGIAGARPKTD------ARAVG
GARSKT--DAKAIPGARPKDEA--------------Q--------------AWAQSEFG-
-----TEAVSQAEGVSQTNAVAWPLATAES--GSVTKSKGLSMDRELVNVDAETFPGTQ-
-GQKGIQPWFGPG-EETN------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---MGSWCYSRPRAR-EEASNESGFWSADETSTASSFWAGEETSVRSWPREES---NTRS
RHRAKHQ-----T--NPRSRPRSKQEAYVDS-WSGSE-----------------------
-DEAGNPFSFWAGENTNNLF----------------------------------------
---------------------RPRVREEANIRSKLRTNREDC--FESESE------DEFY
KQSWVLPGEEA---------NSR-----FRYRDKEDPNTALKLR----------------
AQ----KDV-DSDRVKQEPRF-----EEEVIIGSWFWAEKEA------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------SL
EGG------ASAICESEPGTE-----EGAI------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------GGSAYWAEEKS
SLGA--------------------------------------------------------
-----------------------------------------------VAREEAKPES---
------------------------------------------------------------
------------------------------------------------------------
-EEEAIFGSWFWDRDEACFDL-NPCPVYKVSDRFRDAA-EELNASSRPQTWDEVTVEFKP
-GLF----HGVGFRSTSPFRIPEEAS-----EMLEAKPKNLELSPEG----E--EQESLL
QPDQ--PSPEFTFQYDPSY--------------------RSVREIREHLRARESAESESW
SCSCIQ-----CELKIGSEEFEELLLLMDKIRDPFIHEISKIAMGMRSASQFTR------
----------DFIRDSGVVSLIETLLNYPSSRV------RT-SFLENMIHM-APPYPNLN
MIETFICQVCEETLAHSVDSLEQLTGIRMLRHLTMTIDYHTLIANYMSGF-LSLLTTANA
R-TK-FHVLKMLLNLSENPAVAKKLFSAK---ALSIFVGLFNIEETN----------DNI
QIVIKMFQNISNIIKSGKMSLID---------DDFSL--EPLI-SAFREFEELAKQLQAQ
IDNQNDPEVGQQS-----------------------------------------------
-------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------MTGAEIEPSAQAKPEKKAGEEV--------IA-----------GPERENDVPL
VVRPKV--------------------------RTQ--ATTGARPKTETKSVPAARPKTEA
------QAMSGA------------RPKT----------------------------EVQV
MGGARPKT----------------------------EAQGITGARPKTD------ARAVG
GARSKT--DAKAIPGARPKDEA--------------Q--------------AWAQSEFG-
-----TEAVSQAEGVSQTNAVAWPLATAES--GSVTKSKGLSMDRELVNVDAETFPGTQ-
-GQKGIQPWFGPG-EETN------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---MGSWCYSRPRAR-EEASNESGFWSADETSTASSFWTGEETSVRSWPREES---NTRS
RHRAKHQ-----T--NPRSRPRSKQEAYVDS-WSGSE-----------------------
-DEASNPFSFWVGENTNNLF----------------------------------------
---------------------RPRVREEANIRSKLRTNREDC--FESESE------DEFY
KQSWVLPGEEA---------NSR-----FRHRDKEDPNTALKLR----------------
AQ----KDV-DSDRVKQEPRF-----EEEVIIGSWFWAEKEA------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------SL
EGG------ASAICESEPGTE-----EGAI------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------GGSAYWAEEKS
SLGA--------------------------------------------------------
-----------------------------------------------VAREEAKPES---
------------------------------------------------------------
------------------------------------------------------------
-EEEAIFGSWFWDRDEACFDL-NPCPVYKVSDRFRDAA-EELNASSRPQTWDEVTVEFKP
-GLF----HGVGFRSTSPFGIPEEAS-----EMLEAKPKNLELSPEG----E--EQESLL
QPDQ--PSPEFTFQYDPSY--------------------RSVREIREHLRARESAESESW
SCSCIQ-----CELKIGSEEFEEFLLLMDKIRDPFIHEISKIAMGMRSASQFTR------
----------DFIRDSGVVSLIETLLNYPSSRV------RT-SFLENMIHM-APPYPNLN
MIETFICQVCEETLAHSVDSLEQLTGIRMLRHLTMTIDYHTLIANYMSGF-LSLLTTANA
R-TK-FHVLKMLLNLSENPAVAKKLFSAK---ALSIFVGLFNIEETN----------DNI
QIVIKMFQNISNIIKSGKMSLID---------DDFSL--EPLI-SAFREFEELAKQLQAQ
IDNQNDPEVGQQS-----------------------------------------------
-------------------------------------------

------------------------------------------------------------
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---------------------------------MGYARKVGW------------------
------------------NKEK-MA----EGGSGRVD--DAG----------------DC
---------------------------------------------------------SGA
--RYNDWSDDD-------------------------------------------------
DDS----------------N--------E-------------------------------
------------------------------------------------------------
-SKSIVWYPPWAQ-----------------------------------------------
------------------------------------IG----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------T--------------------------------
-----------EAGTRARARA---------------------------------------
------------------------------------------------------------
---------RARARARAT---------------------------WA----HRAVQKCAS
PNSDD--------TVLSRQELEKFLCLVEISEKPYFLEVALIALGNNAAYTFNR------
----------GIICDLGGLPIVAKILNSRDPIV------KE-K-----------------
---VYMNQVRDDTITSHLNSSVQLAGLRLLTNMTVTNEYQHMLANSISDL-FRLFSAGNE
E-TK-LQVLKLLLNLAENPVMTRELLRAQ---VPSSLRSLFNKKEDK----------EVI
LKLLVIFENINDNFKWEENEPT---------QNQFSE--GSLFF-FLKEFQVCADKVLGI
E-SHHDFLVKVKVGKFMAKLAEHMFPKSQE------------------------------
-------------------------------------------

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-----------------------MINSRATEQARVEVGDGLKAE--------ISSP----
------ENARTRDEPQAMALV-----EAEPKAEIV----TKDKFGDGIMAMTQTVTYTEP
--VTGTREVNKM------------------------------------------------
------------------------------------------------------------
-----------ETMTDTRVMDETKPELLE-ELAIVPQTRSKALPMSRF--NAITKATVRA
A-----------------------------------------------------------
-------SASEASSRSCATAD-----NKANIVSRYEI-----------------------
--------KEEISIKPM----------PR-------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------NKVGIGI-----------------------------KSTDEDEENICSWFW
IGEE------------------------PSVGSWFWPKEEIPLQI---------------
-----YKSPPK---------------------I-QERP----------------------
------------------------------------------------------------
----------------------KPTHK------------------------SKLTIKQKA
-TAW----SRA--RYIVLVPIE------------GE--EQP-LPP---------EGNWTL
VTTLIET--------PLGIRPLTKIPPYNGPYFQTLAE------IKKQIRQREKYGPHPR
ACLCKS-----HCFSLEPKEFDKLVALLKLTKDPFVHEIATMIMGISPAYPFTQ------
----------DIIHDVGIIDMIENLINNPDVDE------DS-GAFDVVDDS-SESSEEPK
MGSKRGRSETP-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------

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----------------------------------------KATS--GAEAEAGGR-----
------------------------------------------------------------
-----------AGA----------------------------------------------
E---------------VEITTT--------------------------------------
-----AKARPKA-SSQAMIMAEAEAEIQSEAKTVARKAEKETN---RVTVT--QSEALGV
TREVA-KMGAINKTGIVAETKAR---APEETVS----VA-KSQSE--ARPGNTVDAKASG
RPQ--ISAEMEAKERSWFRTG-----GETSTGSCLRRGEEAG----IVSKPGDKN--E-A
NIE---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------SRKESWLW
DGDA------------------------ATTGSRLGAEEEACM-----------------
---ESWTLAED------V-DEDELSRASSP-DI-ET------------------------
------------------------------------------------------------
----------------------------KAKKSAE-S----------RGTYPSM-VPGAG
MGSW----AGAMIWTEMK--FP------------YQ--NKSCFPPED----E-----LR-
KQ-I-----------------------------------RY------------EEKTQPW
TCRCKR------EANMDPRELEKLICMIEMTEDPSIHEIANNALYNSPEYPFSH------
----------EVIRNAGRISIIESLLNNPYPSV------RQ-KALNALNNI-SVAAENHR
KVKTYLNQVCEDTVTYPLNSNVQLAGLRLIKHLTIISEYQHMVTNYISEF-LRLLTVGSG
E-TK-DHILGMLLNFSKNPSMTKDLLIAN---APTSLINIFSKKETK----------ENI
LNALSLFENINYHFKRRAKVFTQ--------DK-FSK--NSLY-FIFQRPKACAKKLRVL
AAEYSDPEVKEKVELLLSKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
-------MTGAEIESGAQVKPEKKPGEEVV--------G-----------GAEIENDVPL
VVRPKV--------------------------RTQAQIMPGARPKDKSKVIPGASTKV--
------------------------------------------------------------
------------------------------------------------E------TSAVG
GARPKS--KAKAIPVSRFKEEA--------------Q--------------MWAQPRFG-
-----PERLSKTERNSQTNIIASPLVSTDS--VLVAKTKYLSEDRELVNTDTESFPGRKA
HYQAGFQPFFRSK-EETN------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---MGSWCCPRPTSK-QEVSPNSDFNWVDKSSVSSLFWSGDEVTAKFHPGNRVKD-SARS
RHMANQE-----A--NTMSRSQTNQELYISS-SSGSE-----------------------
-DESVMTPWFWARDKTNTWS--GPREDP-NSRSRFRAKKEVYV------------ESSSG
SEHEDHLESWFGAGEEAKFRCKMRAGKETNNRARHRAKREACIDFMPGSI------DVIK
RESCFWPEENA---------NTF-----SRPMIKKEARARAMAK----------------
EE----AKTKARARAKQEARS-----EEEALIGTWFWATDESSMADEASIESSLQVEDES
IIGSWFWTEEEASMGTGASSKS-RPRTDGEPVGDSLFGTG-EKTSMKTGAEATSECILAA
DDE-QVIIGSWFWAGEE-VN---------------------------------QEAEEET
IFGSWFWVTDAAS-VESGFGVSCE-------------------------------SRSR-
-SEEEEVIGPWFWSGEQVDIEAGIGEE----------ARPGAEEETIFGSWFWAENHTYM
DCR------AEASCGTMQGAE----EEGPIIGSWFWTRVEACVEGDVNSKSSLEDKEE-A
MI-PCFGAKEKVSMKHGTDVRCRFMAGAEETNNRSCFWAEKEPCMYPTCGGIWKTRPEEE
-----EDIVSSWFWSRKYTKPEAIIG------------------------SWLWATEESN
I-DGTGEEAKLLTEEETMINSWFWKD--EAISEATDREESRPEAEEGDIIGSWFWAGEED
RLEPAAEVREEDRLVAEKE-GIVGSWFGAREETIRREAGSCSKSSPKAEEEEVIIGSWFW
EEEASLEAVAGVGFESKPGTEKE----EITVGSWFWPEEETSIEAGSQAVEEMESETEEE
TIFGSWFWAGKE-----VSEEAGPCCVSKSEDD-EEMI----------------------
-IESWFWSGDKATKETGTVATCESKPENEEGAIVGSWFEAEDEVDNRTDNGSNCESRTLA
DEDEAIVGSWFWAGDEAHFES-NPSPVFRAICRSTCSVEQEPDPSRRPQSWEEVTVQFKP
-GPW----GRVGFPSISPFRFPKEA-ASLFCEMFGGKPRNVVLSPEG----E--DQESLL
QPDQ--PDPEFPFQYDPSY--------------------RSVQEIREHLRAKESAEPESW
SCSCIQ-----CELKIGSEEFEELLLLMEKIRDPFIHEISKIAMGMRSASQFTR------
----------DFIRDSGVVSLIETLLNYPSSRV------RT-RFLENMIRM-APPYPNLN
MIQTYICKVCEETLAYSLDSPEQLSGIRMIRHLTITTDYHTLVANYMSGF-LSLLATGNT
K-TR-FHILKMLLNLSENLLMTKELLSAE---AVSEFMGLFNREETN----------DNI
QIVLAIFENIGNNIKKET-VFT---------DDDFNL--EPLI-SAFHKVEKFAKELQGK
TDNQNDPERDQEN-----------------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MTGTKN--KNRVHAKIVKR-A
SVQGKAGEEKEATGV------VKPG---------------------AKNGAKVKVKAKPK
-----ADAV---------------------------------------------------
------REMKTV-------------SKNKVVTDMKERAWSEPKATVKTI-----------
-----ADF----------------------------RCKNESEATSSISKDKASTDTWFW
AGEE------------------------ASINSWFWKGEEAGN-RSSS------------
---------KDENK-------ANTGIQSRV----E-------------------------
------------ELEPVARPSCRSRSGAEDE-----------------------------
EEEENVIGNWFWEGDDSSYDP-NPQPVFRIVKPQP---VDEINEKNRPKDWSEVTIWPKA
PAVTP---AVLGFRSQVPSETRLSS----YIVLSSAEENNRSLPGT-------TACSSKG
TRSTSQPIPEYPFGSDPCI--------------------QTLDEIRHQIKTREVNGTKPF
ACRCKM------ECYLGSGEFEKLVYILKTTTDPLIHKIAQIAMGIYKVHSFAQ------
----------EFINEVGVVTLIESLLSFPSSEV-------RKKAVITR-KS-PFGDERQH
RVELHVKHVCQETISFPLNSPGQQSGLKILGQLTTDYLHHYIVVSYYSEL-FHLLSRGNH
K-TR-NLVLKVLLNMSENSAAARDMINMK---ALAAFKLIFNPEEAK----------SNL
VSAVAIFINIKEHIRKGSIVVVD----------HLSY--NMLT-AIFCEVKGIIEAM---
------------------------------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
---------------MDADALQKLIHLLKATDDPLIQEQALITLSNSAAFSVNQ------
----------DIIRNLDGLSVIGGMLLDCVPTV------KE-KALNALNNL-SMNIKNQE
EIQVYIMQVCKNIESAPLNSDLQLAGLRLLTNMSVTNDYHYKMINKIPCF-LHLLSEGSE
R-TQ-IQVLKVLVNLSANPATTRHFLKAQ----VPSLLLLFDNCINT----------DIL
LRALVFAANLKKNMNSEDGIMM---------EDEYSE--DSVFSILCRDSTAFAQKLASL
L-HHPDTDVKEKQAALKPAW----------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
-------MTGAEVVPSAQAKPEKKPGEEV--------MP-----------GAEGENEVPL
VVRPKV--------------------------RTQ--ATTGAKPKTETESVPRARPKTET
------KSVPGA------------RPKT----------------------------EAQA
MGGARPKT----------------------------EAQGTAGARPKTN------ARVVG
GARPKT--DAKAIPGARTKDEP--------------Q--------------AWGQTEFG-
-----TETVSQAEGVTQTNAVAWPPTTPES--GSVTKSKGLSMDREVVNVDAETFPGTQ-
-GQKGIQPWFGPE-EETN------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---TGSWCYSRPMAR-EKASNESGFWSADETSTISSFWAGEETSIRSWPREES---NTRS
RHRAKHQ-----T--NPRSRPRPQQEAYVDS-WSGSE-----------------------
-DEAGNLFS-WAGENTSNLF----------------------------------------
---------------------GPRVKEEANIRSKSRTKREDC--FESESE------DEFY
KQSFSLPGEEA---------NSR-----FKHRDKEDPKTNLKSR----------------
AQ----KDV-NGDRVKQEPRF-----EEEVIIGSWFWAENEA------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------SL
EGR------ASAICESEPGTE-----EGAV------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------GGSLYWAEEQS
SLGA--------------------------------------------------------
-----------------------------------------------VARQDAKPES---
------------------------------------------------------------
------------------------------------------------------------
-EEDAIFGSWFWDRDEACFDL-NPCPVYKVSDRFRDTAEEELNASSRPQTWEEVTVEFKP
-GLF----HGVGFPSTSPFRFTEDAS-----EMFEAKPKNLELSPEG----E--EQESLL
QPDQ--PGPEFTFQYDPSY--------------------RSVREIREHLRARESAESENW
SCSCIQ-----CELKIGPEEFEELLILMDKIRDPFIQEISKIAMGMRSASQFTR------
----------DFIRDSGVVSLIETLLNYPSSRV------RT-SFLENMIHM-APPYPNLN
MIETFICQVCEETLAHSVDSLEQLTGIRMLRHLTMTTDYHTLIANYMSGF-LSLLTTANA
T-TK-FHVLKMLLNLSENPAVAKHLFSAK---ALSIFVGLFNIEETN----------DNI
QIVIKMFQNISNIIKSGKMSLID---------DDFSL--EPLI-SAFREFEELAKQLQAQ
IDNQNDPEVGQQS-----------------------------------------------
-------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------MTGAEVEPGAQAKAENKPGDENA--------N-----------AAEVEPEVPL
VVRPKV--------------------------RT--QMMTGARPKVKPKGTPGARPKG--
------------------------------------------------------------
------------------------------------------------E------TSSPG
GAYAKC--KPRSIPISRSKHDA--------------Q--------------VWAPSKFR-
-----GESMSKMGKQCQISAADSPLVSNDS--GAVAQAKCLSVDRELANMDTESIPKK-A
SSPARFQPSFGPE-EGTS------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---MGSWYRPRPIPK-GEAYENSDFKWADKSSGSSSFWNRDETSTRFRPRKSMKS-NTRF
RHMAKQE-----A--NTMSRHKNKQEFYNIS-SSDSE-----------------------
-DESAKTPWFWAKDKPKVWS--RPKEEP-NTRSWFRSKKEVRV------------ESTSG
SECENHTKSLFWSGEEAKCRSKPRARKGVNMRARHQAKREAYSDVTSGSV------DKNK
KDSWFLPEEKA---------NAF-----SKSKTKKEPRTRAMPR----------------
EE----VKTKARASTKQEARP-----EEEVLVGAWFWNTQDNTMGERISMKT-TCVEEEP
IVGDWFWSEEEASVDSETGLKS-RPRAKEEQVSSFCLGSG-KKTSMESGPKATSKSMPVA
KDD-EVIIGSWFWADDEEIS---------------------------------LQADDES
IFGSWFWGTGEKS-LRS-VGVSCE-------------------------------KMPK-
S-GEKEVTDSWFWAGE-VNTEAEMEEQ----------ASSASTKGTIFVPWFWSEKQAHM
DLG------TEPCSDIMAGAE-----EEPIIGPWFWAKVDNSVEAEVNSKSSLEDEEE-P
IRSPWFGAREQPNMKYAAGVGYKPMAEAEEANKKSCVWAK-EPCLYPTNRESLKSTLGEK
-----EDTVDPWLWSNNYPRTETITG------------------------SWLWAAEEGN
IDDETGEEIKLPTLEDNVFNSWFWKENEETVVEAPNREESKPEAEEEDIIGSWFWAGDED
RFQPAAKIKEENK-IAPEDEDTVGSWFWGKEE----------------------------
---ASVEAVKGGTFESVSGIKEE-----KATGSWFWTDK-AKIGAGPQT-VETGSETEDE
AIFESLIWAAKK-----DSMQTGVNRVSKPKDE-GE-G----------------------
-IESWLWSGDKATTESKTVTVSESSPENGKESIVKFGSRAKDEVINKTGSGDNCKFST--
-EAESIVGPWFWEGDEASFES-NPVPVCKAACEPESSTEHEPDPSRRPQSWDEVTVQFKP
-GPW----GKAGFPSLNPFRFPKEA-ASLFAEMFGGKPKLVEVGT-E------------R
---E--PEPQFPFQYDPSY--------------------RSVREIREHLKARESAQAENW
SCNCIQ-----CELRIGSEEFEELLLMMDRNRDPFIHEISKIAMGMRGASQFTR------
----------DFIRNSGVISLIEALMNYPSSRA------RT-AFLENMIQM-APTYPDLN
MIETYVCQVCEDTFDYDLDSSDQLSGLTMITHLTTTFDYHKVVVAYLAGF-YYLLNSGNT
T-TR-FHVLKLLLNLSESLVMTKRLLITD---SVSEFMALFNREDSD----------ENI
QIILAIFENISKNIQKEALFADDEE--EEEEEEAVNL--EPLI-SAFREAEKFAKELKRK
TDDQKSP-----------------------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------MTGAEIDPVVQAKPEKKAGEEI--------VG-----------GADRDNEVPL
VVRPKV--------------------------RTQTRVTSRARPKTEVISVPGTRPKSET
------QAMSG-------------------------------------------------
---ARPKT----------------------------EALTMTGARPKAD------ARAIG
CAYPKT--EAKPIPGARPKDDA--------------Q--------------AWAQSEFG-
-----AEAMSQAEGTSQTNSVTWPLVSGES--GSVTKCKSFPMDRELANVDTETFPGTQ-
-GQTVIQPWFGPG-EETN------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---MGSWCYPRPRAR-EEASSESGFWSADETSTVSSFWAGEENNIRSWPREEA---NTRS
RHRAKHQ-----T--NTRARPKSKQEPYVYS-WSGSE-----------------------
-DETGNPFCFWAGETTNNLL----------------------------------------
---------------------RPRVREEANTRSKLRTKRDDC--FESESE------DEFY
KESWFLPGEEA----------NR-----LRHRSTDEPNDMLKSR----------------
AQ----KEIKNVNRAKQESRF-----EEEVIIGSWFWAEKEG------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------GL
ENG------SSAICDPEPEVE-----EGAI------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------GGSLFWAEEKS
SLGA--------------------------------------------------------
-----------------------------------------------VAREEPRPES---
------------------------------------------------------------
------------------------------------------------------------
-EEDAIFGSWFWDRDEACFDL-NPSPVYKAHCRFIHSAEEEVNVSSRPQTWEEVTVEFKP
-GPC----HGVGFPSTNPFTFPELS------ENTEEKLNNLGLIPEG----E--EQESLF
QLDQ--FESEFPFQYDPSY--------------------RSVREIREHLKARESAELENW
SCNCIQ-----CELNIDSGEFEELLLLMDKIRDPFIHEISKIAMGMRSASQFTR------
----------DFIRDSGVVSLIETLLNYPSSRA------RT-SFLENMIHM-APPYPNLN
MIETFICQVCEETLAHGIDSLEQLTGIRMLRHLTVTADYHTLIGNYVSGF-LSLLTTGNA
R-TK-FHILKMLLNLSENPMVAQKLFSAK---ALSIFVGLFNIEETN----------DNI
QIVIKMFQNISNIIKSGAMSLID---------DDFSL--EPLI-SAFHEFEELAKQLQIQ
IDNQNDPEVGQQS-----------------------------------------------
-------------------------------------------

------------------------------------------------------------
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-----------------------------------------------MGRARE--VGWMA
AGLM----IGAGACYCVYKLTI------------GR--DDSDKLEE------E-EEEWDD
DQELDEEEPEFWFDFTTMARPWSEDGDWTEPGAPGGTEDRPSGGGKANRT--HPVKQRTF
PYEHK--------NTWSTQSFRNFRCVLDLSKCPFIQGKMWFAQPKDAGFSFSH------
----------DINSHLASLSIVRNTIPTPGPAI------KE-MALCALDNL-NARVENQG
QIKMYINEVCRETVSHCCNSFLQRAGLDLLIGMTVINN---MLAKSVSDLKFPLLSEGSR
C-AE-VQVLKLLRGLSEKPVLAGELL----------VMSLLIRNGNA----------QVL
PDSLAS------------------------------------------------------
------------------------------------------------------------
-------------------------------------------

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---------------------------------MSRVRDAGCVAAG----------IVIG
AGAWYCVYKYT--RGRDQ-TKKRMV----KSKNRA--MAGTGVRARAGLRAGFTIDLGPG
FSPPTPVQAGTENR-SQDEAFALDVAGAEALAPAV------PSAEAQSGARSQAQEADVP
--RVGPKA-ESEVRDAVDSAIASPSGVAEAP------------TAAEAPAMSGTPKVAEA
PST----------------A--------EG-------PGAAVPTER-AA-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------PTEAAEAPR------------VAVPT---------
---------EVA---GAP------------------------------------G-----
-VSAPSEAAEAPMPTTP------------------------------TG-----AA----
---VP-----------TSGAA-----------------E-AP------------------
----------------------GTSGSPR-------------------------------
-----------TVAVPGAAAAKKATPGAHTGAIPKAGA--AAGA---VPKGGA-------
-------KGGAKGGTRSRNGG-K----GKGK-------------K-NKVEVDELGMGFRP
GD---------GAAAAAAASAN------------GGQAFLAEVPDS-----EEGESGWTD
TESDSDSEPETQRRGRG----------------------------KR----PVPMQKRPF
PYEID--------EILGVRDLRKVLALLQKSDDPFIQQVALLTLSNNANYSCNQ------
----------ETIRKLGGLPIIANMINKTDPHI------KE-KALMAMNNL-SENYENQG
WLQIYMNKVMDDIMASNLNSAVQVVGLKFLTNMTITNDYQHLLVNSIANF-FRLLSQGGG
K-IK-VEILKILSNFAENPDMLKKLLSTQ---VPASFSSLYNSYVES----------EIL
INALTLFEIIYDNLRAEVFN-----------YREFNK--GSLFY-LCTTSGVCVKKIRAL
A-NHHDLLVKVKVIKLVNKF----------------------------------------
-------------------------------------------

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----------------------------MVRHLTRATDYHTLVARYLSGF-LLLLATGNT
E-TR-FHVLKILLNLSENSVMTKELLNAK---AVSEFMGLFSRKETN----------DNI
QVVLAMLENIGNDIKKEAL-FT---------DDDFSL--EPLT-SAFHEVEKFAKELQGK
VDHKKDPEAD--------------------------------------------------
-------------------------------------------

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-------MTRAEVEPGAQAKAENKPGDENA--------N-----------AAEVEPEAPL
VVRPKV--------------------------RT--QIMTGARPKVKPKSTPGARPKG--
------------------------------------------------------------
------------------------------------------------E------NSTPG
GAYAKC--KPKAIPISRSKHDA--------------Q--------------VWAPSKFR-
-----SESMPKMGKQCQISAADPPLLSNDS--GMVAQAKCLPVDRELANMDTENIPKK-S
NSPAGFQPSFGSE-EGTN------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
---MGSWYRPRPVPK-GEAYENSDFKWADKPSGSSSFWNRDEASTRFRPRKSMKA-NNRF
RHMAKQE-----A--NTMPRHKNKQEFYNIS-SSDSE-----------------------
-DESGKTPWFWAKDKTKVWS--RPKEEP-NTRSWFRSKKEVRV------------ESTSG
SECDNPTKSLFWSGEEAKSRSKPRARKGVNTRARQQAKREACSDATSGAV------DTNK
KESWFLPEEKA---------NAF-----SKSKTKKEPRTRVVPR----------------
EE----VKTKARANAKQEARP-----EEEVLVGAWFWDTQESTMADRISIKT-TFVEEEP
IVGDWFWSEEEASVDSETSHKS-RPRAKEEQVSSFCLGSG-KKSSMESGPKATSKSMPVA
KDE-EVVIGSWFWADDEEIA---------------------------------LQADDES
IFGSWFWGTGENS-LRS-VGVKCE-------------------------------KMPK-
ISGEKELTDSWFWAGD-VNTEAEVEEQ----------AGSASTKATIFVPWFWSEKQPNM
DLG------PEPCSDIMAGAE-----EEPIIGPWFWAKVDNSVEAEVNSKSSLEDEEE-P
IRSPWFGAREQSDMKYAAGVRYKPMAEAEDANKKSCVWAK-EPCLYPTNRECLKSTLGEK
-----EDTVDPWLWSNNYPRTKSITG------------------------SWLWAAEEGN
IDDETGEKIKLPTLEDNTFNSWFWKDNEETIVEAPNREESRPEVEEEDIIGSWFWAGDED
RFQPAAKINEENK-IASEDEDTVGSWFWGNEE----------------------------
---ASLEAVRRGTFESAPGIKEE-----KVTGSWFWTDK-AKIGAGSQT-VETGSETEEE
AIFESLIWAAKK-----DSMQAGVTCVPKPKDE-GDMA----------------------
-VGSWLWSSGKTTKEAKTPIVSETSPENGKESVVKFGSRVNDEVINKTGSGDNCKNST--
-EAETIVGAWFWEGDEASFES-NPVPVCKAVCEPEPSAEHEPDPSRRPQSWDEVTVQFKP
-GPW----GKAGFPPINPFRFPKEA-ASLFAEMFGGKPKLVEGGP-E------------R
---E--PEPRFPFQYDPSY--------------------RSVREIREHLKARESAQPENW
SCNCIQ-----CELRIGSEEFEELLLLMDRNRDPFIHEISKIAMGMRSASQFTR------
----------DFIRNSGVVSLIEALLNYPSSRA------RT-RFLENMVRM-APPYPDLN
MIETYVCQICEDTFDYDLDSPDQLSGLTMITHLTATSDYHKVVVNYLAGF-FYLLNSGNT
K-TR-FHVLKLLLNLSENLFMTKRLLVTD---SVSEFMDLINREESD----------ENI
QIVLAIFETISKHIQKEALFTDDYDD-DEEEAEAVNF--EPFI-SAFREAEKTAKELKRK
PGNQKAP-----------------------------------------------------
-------------------------------------------

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---------------------------------MGYARKVGWVTAG----------LVIG
AGACYCIYRLT--RGRKQNKEK-MA----EGGSRDVD--E--------------------
---------------------------------------------------------AGA
--RYNDWSDDD-------------------------------------------------
DDS----------------N--------D-------------------------------
------------------------------------------------------------
-SKSVVWYPPWAR-----------------------------------------------
------------------------------------IG----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------T--------------------------------
-----------EAGTRARARA---------------------------------------
------------------------------------------------------------
-------------RARAT---------------------------RA----RRAVQKRAS
PHSDD--------TVLSPQELQKILCLVEMSEKPYILEAALIALGNNAAYAFNR------
----------DIIRDLGGLPIVAKILNTRDPIV------KE-KALIVLNNL-SVNAENQR
RLKIYMNQVCDDTITSRLNSSVQLAGLRLLTNMTVTNEYQHMLANSISDF-FRLFSAGNE
E-TK-LQVLKLLLNLAENPAMSRELLRAQ---VPSSLGSLFNKKENK----------EVI
LKLLVVFENLNDNFRWEENEAT---------QNQFGE--GSLFF-FLKEFQVCADKVLGI
E-SHHDFLVKVKVGKFMAKLAEHMFPKIQE------------------------------
-------------------------------------------

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-----------------------MIGSKTKKKAREESGASSKPG--------TNSP----
------ANAKGKAKSQTKKAV-----KAEPKEEWG----NQAEARDDAAARTQPAVSTEP
--KTVTWKIKKK------------------------------------------------
------------------------------------------------------------
-----------KEKTNARVVAQAKTELLA-EPALMPHTKSDALPTSVV--ITVTKSEVKV
D-----------------------------------------------------------
-------TGIEASVKGSAKAT-----EKRSIKHKPEI-----------------------
--------KKEVCVKSR----------AGDKA-------------KE---V---------
------------------------------------------------------------
-----C-------------------------------VKSRAGD--KAK-----------
EVCVKSRAGDKASIVI-----------------------------NTTDEDEDYVCSWFW
TGEE------------------------PSVGSWFWPKEENPLQV---------------
-----YQPPPK---------------------V-EEEP----------------------
------------------------------------------------------------
----------------------EP-PD-----------------------TFDYALKKKA
-AAW----LRG--RFIVLVPIE------------EP--QPS-LPP---------DGNWTL
VATLIET--------PLGIRPLTKIPPYGGPYFQTLAD------LKNQIREKEKYGPNPN
TCRCKS-----RTFSLEPVEFDKLVALLKLTRDPFIHEIATMIMGISPAYPFTQ------
----------DIVHDVGITVMIENFVNNPNAKK------YP-RTLNIN-AD-PDAPEEVK
ETEAHVNKVCRDILCCPLNCSVQVEELKLLVSLSVKFDYHHVVIYYVRYF-ISLLNKGSV
K-IK-FQILRVLLCLSKNQANTRELISAE---VMSALVALFHKNESK----------ANI
LHIIEIFENINFQFKKRAKLFNK--------EM-FTK--SELI-SIFREAKEFDQKLQDL
T-DHSDPDVRDKVIRLILKL----------------------------------------
-------------------------------------------

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-----------------------------------------------MGRARE--VGWMA
AGLM----IGAGACYCVYKLTI------------GR--DDSEKLEE------EGEEEWDD
DQELDEEEPDIWFDFETMARPWTEDGDWTEPGAPGGTEDRPSGGGKANRA--HPIKQRPF
PYEHK--------NTWSAQNCTNGSCVLDLSKCLFIQGKLLFAEPKDAGFPFSQ------
----------DINSHLASLSMARNTSPTPDPTV------R--EALCAPDNL-NASIESQG
QIKMYINEVCRETVSRCCNSFLQQAGLNLLISMTVINN---MLAKSVSDLKFPLISEGSG
C-AK-VQVLKPLMGLSEKPVLAGELVGAQ---MLFSFMSLFIRNGNR----------EIL
LETPAP------------------------------------------------------
------------------------------------------------------------
-------------------------------------------

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-------MTGAEIEHAAQEKPEKKAEEEIG--------G-----------GAERKNKVPL
VVRPKV--------------------------RTQAQVMPGVRPKSDVMVVSGAKPKA--
------------------------------------------------------------
------------------------------------------------E------TMAVG
VVHTKN--EAKVIPGVRPTDKT--------------P--------------SWTMTEYD-
-----GEEMLKREGVSQTNSIAWPLVSTEF--ESVGKTKTLSMDKELISVDTDFFPVTKV
KSQLGIQPLFGSE-EKSN------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---VGSWWCPMPTFK-QEISHNCDFRTVDISCLNSWFWSGEEVSTKFHPRDRVKA-NARS
RHKAKEE---------DMSRPNTNWEFYVS--SAGSE-----------------------
-DESIKTSWLWAREKANIWS--MPKEET-NNRSRFRSKKEVF-------------ESISG
SECEDNVNSWLWAREEGKCRSKPRVRKGANVRARHRTKQEASIDFVSGSL------DVVQ
KESWFWPGEKA---------NNL-----SRPKFKKEAKARIMAK----------------
EK----VKNKARAMAKPETRS-----KEEFLIGTWFWAAEESSIVGGASVKYSSQVEDDS
IFGSWFWTEKEASIETDASSKS-SPSTEEESIGNFILGSG-EKASMETGAEATSKSMLED
YKE-NVIVGSCFWISEE-TN---------------------------------LEAEEET
IFGSWFWVSDGAS-MEVDIRASCA-------------------------------SRLR-
-SEEEGVIGPWFWDGKEVDTEAEFGE-----------ARPGDEEESIFGSWFWAGNQAKM
DSG------AKVSCDTMPGAE-----EEPIIGSWFWNGIETCVGTEVSNKSTLKDKEE-V
IISSWFGTTEEVSIKYGTGARCKFMAEAEEINNESCFWDEEDPCIYTANGSRWKSRPEEE
-----QDTVNSSFWSRKHTRPETIIG------------------------PWLQATEEVS
TDDGTGEETNPLIEEETMITSWFWKGD-ETIRVATDKEESRPDAEEEDIIGSWFWAGEED
RLKT-AEAREEDRLAAEEE-AIVGSWFWTRKEIIRKEAGFCNKCSPEAKEEEAIVGSSFW
AEKEA-SMEAGASFESMPVTEEEEITSSVLVGSWFGAEKDNSIEVGPQAIEESRSRTEEE
ITFGSWSCAAKE-----VSVEAETFCAFNPEDD--EII----------------------
-VESWFWSEEKAINETGTVVTCKTRPDNEEKAVFGSWFGAKDEANNRTDNGTNCETRTVD
EEDDPIVGSWFWAGDEAHFES-NPNPVFRAICRSRCSFEQEPDASHRPQSWEEVTVQFKP
-GPW----GRVGFPSPIPFRFPKEA-ASMFFEMFGGKPKHMELNPEG----E--EQESLL
QPDQ--PDPEFPFQYDPSY--------------------RSVREIREHLRARESAEPESW
SCSCIQ-----CELNIGSEEFEELLLLMDKIRDPFIHEISKIAMGMRSASQFTR------
----------DFIRDSGVVSLIETLLNYSSSRV------RT-SFLENMIHL-APPYPNLN
MIQTYVCQMCEDTLSYSLDSPEQISGIRMIRHLTTTTDYHTLVAKYMSGF-LSLLAMGNT
R-TR-FHVLKILLNLSENPVMTKELLSAE---AMSEFMGLFNRKETN----------DNT
QVVLAMFENIGNNIKKEMVLFT---------DDDFSL--EPLI-SAFHEVEEFARELQSK
TNDQYDPEAGQ-------------------------------------------------
-------------------------------------------

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---------------------------------MGRTREAGCVAVG----------MVIG
AGACYCVYRLT--WRKDE-NEKTWD----DDDEESSD--TSE------------------
-----------------------------TGVETE------KGAKINVGVGVGAKPQSDT
-----------------------------KA------------KAEVRLGLESGPGVKKE
SHC----------------G--------SQSGGGLE---AKA------------------
-----------------KALFNI-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------L----------------------------------
----------------KEQASAKVGKGGRVGNIS--------------------------
---------------------------------------------GNRTLAPSLPCPGGR
GG---------GCHSAKSGARA---------------------------------GSKAS
GKSKGKARSKSTRALP-T---------------------------TW----PVRRGKFNF
PYKID--------DILSTPDLQKVLNILERTNDPFIQEVALVTLGNNAAYSFNQ------
----------NAIRELGGVPVIAKLIKTKDLII------RE-KTYNALNNL-SVNAENQG
KIKTYISQVCDDTMICRLDSAVQMAGLRLLTNMTVTNHYQHLLSYSFPDF-FALLFLGNH
F-TK-IQIMKLIINFTENPAMTRELVSCK---VPSELISLFNKEWDR----------EIL
LNILTLFENINDNIKSEGLASS---------RKEFSR--SSLFF-LFKESGVCVKKIRAL
A-NHSDLVVKVKVLKVLTKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
--------------------------------------------MGRIPEVGWVTAGLVI
WAGTCYYIYKFTKGRAQSVRTLARNGSTV-KMETVVG----VQSQTLAISEAE----IKT
KPQAEIGAEIGARSGPGAEVETKATAIAIHRANSQ----AKAMVGAEPEIQSE-------
SKVVAGTLVMTEAVTLTEVK--AKAREVAMKEAVTQTDAEAGKIVKKEAVTQTK-AKAWA
VVAKTEAKREAMTQTKAETHILWPRWGPRTRLE---------------------------
--------------LWMKPRQEARPGATVDARGNPNGMSREVAGVDMKSCAQSQAVAKIQ
GDDMPGTGAEDMGNCK---------------------------TMSRAESGADTRASAKP
QIVAKTQTEAIPGAKVDAGGNTNAMCRVGAGADVRACI-QPQTVAKKQAEVTSSAR-VDG
RGNTNVISKAITGADMRAAAQPQAVASTHAEAMSDAKVKNRGNPNAMTKAGARANLRANS
QVEALPDARDKSRGNPNVMAKVGDGTDMLSCT-QPQLVAC--------------------
----------------------------------------TGAGMDVKTCTQPQAGVKTP
AEALLDSRVDSRGNPNATSKAGTKADQRACGQPLVVANPQGEVLPGAKNKVKGNPHAALK
VGAGEGTTDSAQPEAA---------------------------------------VSFQG
EALLGTKNKVKGNPNVVLKAEVGAGAVGTAQLQIVASSKGEALLDSKNKVKGNSNAVSKA
GAGTDTTGSVQPQIVANSQGEVLPGAKNKVRGNPTTVSNSGVGPYT--------------
--------------------------TDSAQPQAVANSQGEILPGAKNKVKANLNVLSKA
EAGMGAT-----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------GSVQPQAVANSHCE--------
--------------------------------TLPGAKNKVRGNWNAVSKAGAGMDIRGS
AQPQAVANSQGEVLPGAKNKVKGNPNVVSKAG-----AREDTMGSAQPQVVANSQRETLP
GARNKVKGNSNAISKAEAGAGIMGSVQVQVVANSRGEVLPGAKNKVRGN--SNAVPKAEA
GADTVGSAQPQAVANSQSETLLGARNKVKGNTNAVPKAGTGAGTRHSAQPQIVAGSQ---
-------------------------------------GETLPGARDKAMPSSGAEATAED
EVYAKPE--TEAMPTSESEGGSGTQACRKTQPNIHDYYWNGIGVEDWIAAERWIKFRFQT
MDGDWENSVSWADDENEASIGSWSGA-SDK--AGIIRSWAVAC----DETSVKSWAGARA
ENVVGIGTWARAG-EQASGGLWAGGQTSEGTWAGD------------KASGGAWTGAENQ
ASAGSWALTGDQAIGDLWAAGQASDGSWPGGQASGVSWVGQEAIGGSWTG--------AE
NQASGGSWAGA------------------------GAGNMSSVSYWAGVVDQAGG-GSWA
GT------------SDQSGGGSN--------GEVFWGWSG--------------------
------------------------------------------------------------
------------------------------------------GQGIGGSILGPEDQSSGR
CWDDSTEQSSGGSRLVH-------------------------------------------
------------------------------------------------------------
--------------VDHGQDVGGSRPGPTNQSSSGFWDSTASQVSGSCWTGAGAVDQAGG
CSKPGFEDQAIGGGFWPGAGDQTRGGSRPGSEDQS--SGIGSWGVAGGQVL---------
------------------------------------GGARPGPADQSSGGSWAGTG---N
QSSGRSWIGPG--DQ-AGDCSKPEFEDQ-ACGGGSWAGAGSQASGESWAGSRPGNE----
---AIGG-----S--R-----------------MGSEDQ---------------------
----------------------------ATGGSWARSEDQASGRFQVSFEVEANEGFWFG
PGAEAVIGSWCWTEEKADIVSRPDDKDEATTTSRSGAGEEAIICSRIEAE------NKAS
SGSWIRSEEVG--------AE-------A-------------------------------
------------------------------------------------------------
----------------------------------------------------GA------
EAGG--------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------LGLRLGLXXXXXXXX---------------
---XXXXXXXX------X-XX---------------------------------------
------------------------------------------------------------
---------------------------------------------------------XXX
XXXX----XXXXXXXX------------------------TKFAHQN----E-----SR-
KQ-T-----------------------------------RT------------GEKTRPW
SCRCKH------EANMDPRDLEKLICMIEMTEDPSVHEIANNALYNSADYPYSH------
----------EVVRNVGGISVIESLLNNPYPSV------RQ-KALNALNNI-SVAAENHR
KVKTYLNQVCEDTVTYPLNSNVQLAGLRLIRHLTITSEYQHMVTNYISEF-LRLLTVGSG
E-TK-DHVLGMLLNFSKNPSMTKDLLIAN---APTSLINIFSKKETK----------ENI
LNALSLFENINYHFKRRAKAFTQ--------DK-FSK--NSLY-FLFQRPKACAKKLRAL
AAECNDPEVKERVELLISKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
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---------------------------------MGGTRYARWVAEG----------LLLG
AGACYGIXXXX--XXXXX-XXX---------XXXXXX--XX-------------------
------------------------------------------XXX---------------
------------------------------------------------------------
---------------------------------XXX---XX-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------XX-------------------------------
------------------XXX-X----XXXX--------------XX---------X-XX
XX---------------XXXXX------------XXXXX---------------------
--------------XX-------------------------------------X---DLT
NCSCD--------DVLNAEQLQKLLYLLQSAEDPIIIEKALVTVGNSAAFSVNQ------
----------VIIRELGGIPIVGSKINHPNLSI------KE-KALNALNNL-SVNVENQV
KIKVYINQVSEDVFSDPLNSPVQMAGLRLLTNMTVTNDHQHMLNNYITDL-FHVLLIGNG
S-TK-VQVLKLLVNLSENPAMTEQLLSAQ---VDPSFLSLCDGHVAK----------EIL
LRVLTLFQNINNCLKKKNRLAL---------QSNFPE--GSLFFLLYGE--ECAQKMEAL
V-YHQDDEVKEKVTI-IPKNW---------------------------------------
-------------------------------------------

------------------------------------------------------------
--------------------------------------------MGRVQEVGWATAGLAI
WAGTCYYLYRLTKGRAQSVTRLARNGSRV-NMETVVG----VQNQTLAMSEAMAGVEIET
RPKDKTEAKTE-GNEPGAEEETKVTTIEGSKANSQ----SKAMVGAKTEAQSE-------
AESVARTLVMVDAVTLTEAK--VKAREVATKEAMTQTDAEAGEIVKKEAVTQTK-AKAWA
LISKTEARKEAMTQTKAETRTLAEKETEINRVMVTQSEVLAVTKE----VVKIGTMNKTG
IVVESKTRALEETVSVVTTQSDGRLGTTVDARKNHNGMSRAVAVMDVKSCAESQAVAKMQ
DDDMPAAEVEDKGNLK---------------------------TMPKAGSKVDTRAFPQP
QIVVKTQAEAMPGTKVDMEANITTICKAELGTNVRACIIQPQTVAKKQAEAMSGAR-VDG
RENTTAVSKAMTGAVVQAASQIQAVACAQPESMPDARVKGRSNPNGMVKAGAMTNIRTNL
QDEALPDNSHKTRSIPSVTIKAGAGMDMLSST-QAQPVANVQSDALPDGRIKTKGTVNAV
IKEGAQA--------TAQNQGEALLTTKGKARGKAKAKCKGGVGPDLKTCSQSQAGTKTQ
AEVLPDSRVDGRGDSNAISKAGP---NRTGAQLQAVVTSHGDALPGTRNKLKSCPNAVPK
AEAVTATADCAQPQVLVSSQSETLI-----------------------------------
------------------------------------------------------------
------------ATVTSSQGEALPGAKNKVKGNLSATPKTETVV----------------
------------------------GVTGSAFPQALTNSQGDI------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------LTGTRAKVKGNPSTMPKPEVGVGIT--
--------------------------------------DSFRSQTVASSQDETLLGARSK
VR----------------------------------------VNCNIP-KAEVGAGTL--
----GSSHSQGEILLGARNKVKGCPSTMPKAE-----AEAGIVSSSQPQALTSSQNEALL
GARNKVRGNSSAVPKAGPQKGTKVSAQPQGMVSS--------------------------
------------------------------------------------------------
-------------------------------------PEALLGVMGKAMSRSEAEATTEA
KVCAQPQAEAGAAPASESEGGP------DAQPNVHDYYWNGIGVEDWIAAERWIKFRFQA
MDGDWENSVSWADDKNETSIGSWSGT-GDK--SGTVSSWTVAC----DETTIKSWAGARA
ENEVALGSWAGAG-DQASGGLWAASQVSEASWTGD------------KAVGGSWTGTENQ
VSGASWVVSGNQAIAGPWAVGQVSEVPWPGVQAAGVSWVVDQASGGSWTV--------AE
NQASAVSWAGA--------------------------GNIVSIGYWTGAVDQANA-GSWI
GA------------GNQSGSESKPRFEDQASEKRSWAGADGQASGDSSLVPENQSSGRSW
ADTADQASRGSRLGPVDQSSGASWAGAMEQAGGGSTSVSEDQPSGAPWPGTSNL------
------ARGGSWTGTGDQSGGGSKPSFKNQATDEG-SWAGAFGQAGGVSKSEHEDQSSGR
SWADSGDQISGRFLVGVVDQANGKSQASP----GDLAGGGAKPVFEDQAGGGGCWTNAAG
DQPGRESRLGPREQSSADSWSGTGDQASG------------WF-------------CAYT
G---SQISGAGSWGGTGGQDVGVSRPGPMNQASGGSWAGTGSQISGVSWAMP--GVQAGG
CSKPGFGNQAMAAGFWAGAGNQAGGGSRPG-------SEGGSWPGTSVHVI---------
------------------------------------GASRPDSADQPSGSSWAGIG---S
QVSGGSWVGPG--DQ-AVGCSKPGFENQ-VRGGSAWAGAGDQ------------------
--------------------------TNGVS-WVGSEDQASG------------------
-------------------------------------------RFLVSAEVEANEGFWFG
PGSEAFIGSWCWTGEEAGVVSRPDGKDEASSESASGPKEETTVSSELSDE------NKAS
AGPRIRSEEVA--------YM----GSCVKAESGSETGAAVEAE----------------
------------------------------------------------------------
-------------AGAEA----------------------------------EA------
EAE---AK----------------------------------------------------
--------------GEAEAEAEAEAE-------VKREAEPEPEAKGEVKAG--AETEAGS
EAEAEAEAGAEAGAGAEA--EAEAGAEAEAEAG----AGAEAEAE--TEVGAEAEAEAET
GPE--VGAEAEAGAGAGAGAG-----AEVGA----ETGPEVG----AEAEAGAET-----
--GPEAGAGAEAGAGAE----------VGAET----------------------------
------------------------------------------------------------
----------------------------------------------GP----EDGA----
--ETGAGAGAGAGAGA-----------------------------ETEAGAEAIMGSWPW
DGEV------------------------TTKGSGLRAKEKVGI-----------------
---WSWALARD------V-DEDELSGASSP-DI-EEIS----------------------
-LRSLFWAESENSHECRSE--------SGKD--INFESGVEDEE-SIQDQYEASIMDQFE
ATDGVDIRSWFCTGNESRSED-KSTPKANAKKSAE-S----------RGTYPCM-VPGAG
MGSW----EGATIWSEVK--FP------------HQ--NEASFPSGD----E-----FR-
QQ-N-----------------------------------RA------------GEKARPW
SCRCKH------EANMDPRDLEKLICMIEMTEDPSVHEIANNALYNSVDYPYSH------
----------EVVRNVGGISVIESLLNNPYPSV------RQ-KALNALNNI-SVAAENHR
KVKTYLNQVCEDTVTYPLNSNVQLAGLRLIRHLTITSEYQHMVTNYISEF-LRLLTVGSG
E-TK-DHVLGMLVNFSKNPSMTKDLLIAN---APTSLINIFSKKETK----------ENI
LNALSLFENINYHFKRRAKAFTQ--------DK-FSK--NSLY-FLFQRPKACAKKLRAL
AAECSDPEVKERVEILINKL----------------------------------------
-------------------------------------------

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---------------------------------MGYARKVGWVTAG----------LVIG
AGACYCIYRLT--RGRKQNKEK-MA----EGGSGDVD--DAG----------------DC
---------------------------------------------------------SGA
--RYNDWSDDD-------------------------------------------------
DDS----------------N--------E-------------------------------
------------------------------------------------------------
-SKSIVWYPPWAR-----------------------------------------------
------------------------------------IG----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------T--------------------------------
-----------EAGTRARARA---------------------------------------
------------------------------------------------------------
-------------RARAT---------------------------RA----RRAVQKRAS
PNSDD--------TVLSPQELQKVLCLVEMSEKPYILEAALIALGNNAAYAFNR------
----------DIIRDLGGLPIVAKILNTRDPIV------KE-KALIVLNNL-SVNAENQR
RLKIYMNQVCDDTITSRLNSSVQLAGLRLLTNMTVTNEYQHMLANSISDF-FRLFSAGNE
E-TK-LQVLKLLLNLAENPAMSRELLRAQ---VPSTLGSLFNKKENK----------EVI
LKLLVIFENVNDNFTWEENEPI---------QNQFGE--GSLFF-FLKEFQVCADKVLGI
E-SHHDFLVKVKVGKFMAKLAEHMFPKNQE------------------------------
-------------------------------------------

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------------------------MTGFEAKARRGGAGAGLKAG--------ICGP----
------ANTRAKAKIHAKAVA-----ETESETGPV----TQAKPGDGAMARIQAVTYTEA
--VP-TREVSKM------------------------------------------------
------------------------------------------------------------
-----------EAKTKTRVVAETKADPPT-EPGIVSQTKSKAMPMSRV--SAVTKYEVKA
G-----------------------------------------------------------
-------AGSEVNIRSFAKAD-----GKDNIGSRSQR-----------------------
--------RREASIKLK----------SS-------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------D-----------------------------------------EAEENVCSWFW
TGEE------------------------PSVGSWFWPEEETPFQV---------------
-----YKPPRK---------------------I-QEKP----------------------
------------------------------------------------------------
----------------------KPK--PK----------------------PELTIKQKA
-AAW----SRA--RFCVLVPVE------------GG--ERS-LPP---------EGNWTL
VETLIET--------PLGIRPLTKIPPYNGPYFQTLAE------LKKQVKYREKYGPNPK
ACRCKS-----HVFSLEPKEFDKLVALLKLTRDPFIHEIATMIMGISPAYPFTQ------
----------DIIHDVGITVMIENLVNNPNVKE------HP-RTLNMVDDN-SESSGEPK
TGESYVNQVCKDIISFPLNSPEQLAGLKLLVQLSVKFEDHHMIVNYIPDI-LTLLNKGSG
K-TK-FYVLKVFSRLSKNQANTRELISAK---VLSSLVAPFNKNESK----------ANI
LNTIEIFENINFQFKKKVKLFTK--------EE-FTK--SELI-SIFQEAKQFGQKLQDL
A-EHSDPEVRDKVIRLILKL----------------------------------------
-------------------------------------------

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-------------------------------------------------------MGFRP
GD---------GAAAAAAASAN------------GGQAFLAEVLDS-----EEGESGWTD
TESDSDSEPEIQHRGRG----------------------------KR----SVAMQKRPF
PYEID--------EILGVRDLRKVLALLQKSDDPFIQQVALLTLSNNANYSCNQ------
----------ETIRKLGGLPIIANMINKTDPHI------KE-KALMAMNNL-SENYENQG
RLQVYMNKVMDDIMASNLNSAVQVVGLKFLTNMTITNDYQHLLVNSIANF-FRLLSQGGG
K-IK-VEILKILSNFAENPDMLKKLLSTQ---VPSSFSSLYNSYVES----------EIL
INALTLFEIIYDNLRAEVFN-----------YREFNK--GSLFY-LCTTSGVCVKKIRAL
A-NHHDLLVKVKVIKLVNKF----------------------------------------
-------------------------------------------

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-----------------------MIGSKTKKKAREESGPSPKPG--------TNSP----
------ANAKGKGKGQTNKGG-----KAEPKVEWG----NQAEARDGAVARTQPVVPTEP
--KTVTWKVKKK------------------------------------------------
------------------------------------------------------------
-----------KDKTNTRVTAQAKTELLA-EPALVPHTKSDALPPSVL--ITVTKSEVKV
D-----------------------------------------------------------
-------TGGEPSVKGSAKAN-----DKHSIKHKSEI-----------------------
--------KKEVCVRSR----------A--------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------GDKASNVN-----------------------------TTDEDDEDYVCSWFW
TGEE------------------------PSVGSWFWPKEENSLQA---------------
-----YQPPPK---------------------V-EEEP----------------------
------------------------------------------------------------
----------------------EP-PD-----------------------TFDFALKKKA
-AAW----LRG--RFIVLVPIE------------EP--QPS-LPP---------EGNWTL
VATLIET--------PLGIRPLTKIPPYGGPYFQTLAD------LKNQIREKEKYGPNPK
TCRCKS-----RTFSLEPVEFDKLVALLKLTRDPFIHEIATMIMGISPAYPFTQ------
----------DIVHDVGITVLIENFVNNPNAKK------YP-RNLNLN-AN-PDAPEEVR
ETEAHVNKVCRDILSCPLNCSVQVEELKLLVSLSVKFDYHHVVIYYVRYF-ISLLNKGSV
K-IK-FQILRVILCLSKNQANTRELISAE---VMSSLVAHFHKNESK----------ANI
LHIIEIFENINFQFKKRAKLFTK--------EM-FTK--SELI-SIFREAKEFDQKLQDL
T-DHSDPDVRDKVIRLILKL----------------------------------------
-------------------------------------------

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-------------GILDAQLLKKLIYLLQSTKNPLIRERALITLGHSAAFSTNQ------
----------VIIRNLDGLLIIGNLLKDPNPKV------KE-KALNALNNL-SMNIQNQK
EIQVYLSQVCEETFSSPLNSDVQLAGLRLLTNMTVTNDYQHLIANSISSL-FDLLSLGNE
N-TK--------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------

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---------------------------------MGYARKVGWVTAG----------LVIG
AGACYCIYKLT--RGRKQNKEK-MA----EGGSGDVD--DAG----------------DC
---------------------------------------------------------SGA
--RYNDWSDDD-------------------------------------------------
DDS----------------N--------E-------------------------------
------------------------------------------------------------
-SKSIVWYPPWAR-----------------------------------------------
------------------------------------IG----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------T--------------------------------
-----------EAGTRARARA---------------------------------------
------------------------------------------------------------
-------------RARAT---------------------------RA----RRAVQKRAS
PNSDD--------TILSPQELQKVLCLVEMSEKPYILEAALIALGNNAAYAFNR------
----------DIIRDLGGLPIVAKILNTRDPIV------KE-KALIVLNNL-SVNAENQR
RLKVYMNQVCDDTITSRLNSSVQLAGLRLLTNMTVTNEYQHMLANSISDF-FRLFSAGNE
E-TK-LQVLKLLLNLAENPAMTRELLRAQ---VPSSLGFLFNKKENK----------EVI
LKLLVIFENINDNFKWEENEPT---------QNQFGE--GSLFF-FLKEFQVCADKVLGI
E-SHHDFLVKVKVGKFMAKLAEHMFPKSQE------------------------------
-------------------------------------------

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------------------------------------------------------------
---------------------------------------MTGTKS--KARGQAKTEKR-A
KVQGKAGAEKEVTGA------VKPV---------------------AKTRSKTKAKAGYK
-----ADIV---------------------------------------------------
------TDVKVI-------------SKNRIVAEMKDRVLSEPKAPVKAL-----------
-----ADV----------------------------SSKAENEVARSTYKDKAGNDTWFW
AGEE------------------------ASISSWFWKGEESGN-HSST------------
---------KDKNK-------GDTSAQVCA----D-------------------------
------------KLESVAGASCKSMSGVDD------------------------------
-EEENVIGNWFWEGDETSFDP-EPKPVYRIVRPQP---VDAINQKNRPKDWSEVTIWPKA
PAVTP---AVLGFRSQVPSETRPSS----YIVVSSTEDSTHSP--------AAAACSSRN
TCSSSQPIPESPFGSDPCI--------------------QTIDEIRQQIKIREVNGIKPF
ACPCKM------ECYLDSEEFEKLVSILKSTTDPLIHKIAQIAMGIHNVHPFAQ------
----------EFINEVGVVTLIESLLTFPSPER-------RKKTVITL-NP-LSGDERQR
KIELHVKHMCKETVSFPLNSPGQQTGLKILGQLTTESVHHYIVASYFSEL-FHLLSQGNR
K-TR-NLVLKVLLNMSENPTAARDLISMK---ALAALKLIFNQKEAK----------ANL
VSAVAIFINIKEHIRKGSIVVVD----------HLSY--NTLM-AIFREVKEIIETM---
------------------------------------------------------------
-------------------------------------------

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---------------------------------MGYVKKVGWVTAG----------LVIG
AGACYCIYRLT--RGRKHNKEK-MA----EGGSGDVD--DAG----------------DC
---------------------------------------------------------SGA
--RYNDWSDDD-------------------------------------------------
DDS----------------N--------E-------------------------------
------------------------------------------------------------
-SKSIVWYPPWAR-----------------------------------------------
------------------------------------IG----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------T--------------------------------
-----------EAGTRARARA---------------------------------------
------------------------------------------------------------
-------------RARAT---------------------------RA----RRAVQKRAS
PNSDD--------TVLSPQELQKVLCLVEMSEKPYILEAALIALGNNAAYAFNR------
----------DIIRDLGGLPIVAKILNTRDPIV------KE-KALIVLNNL-SVNAENQR
RLKIYMNQVCDDTVTSRLNSSVQLAGLRLLTNMTVTNEYQHMLANSISDF-FRLFSAGNE
E-TK-LQVLKLLLNLAENPAMIRDLLRAQ---VPSTLGSLFNKKENK----------EVI
LKLLVIFENINDNFKWEENEST---------QNHFCE--GSLFF-FLKEFQVCADKVLGI
E-SHHDFLVKVKVGKFMAKLTEHMFPKNQE------------------------------
-------------------------------------------

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-----------------------------------------------MGRARE--VGWMA
AGLM----IGAGACYCVYKLTI------------GR--DDSEKLEE------EEEEEWDD
DQELDEEEPDIWFDFETMARPWSEDGDWTEPGAPGGTEDRPSGGGKANRA--HPIKQRPF
PYEHK--------NTWSAQNCKNGSCVLDLSKCLFIQGKLLFAEPKDAGFPFSQ------
----------AINSHLASLSMVRNTGPTPDPTV------R--EALCATDNL-NASIESEG
QIKMYINEVCQETVSRCSNSFLQQAGLNLLISMTVINN---MLAKSVSDLKFPLISEGSG
Y-AK-VQVLKPLMGLSEKPVLAGELVGAQ---MLFSFMSLFIRKGNR----------EIL
PETPAP------------------------------------------------------
------------------------------------------------------------
-------------------------------------------

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---------------------------------MGRTRDAGCVAAG----------VMIG
AGACYCVYRLT--WGRDE-NEKIWD----DEESSDGA--ETG------------------
-------------------------------VQTE------KRAQANPEVV---------
------------ASAR--------AEADLVA------------KAEVCLEVKSGPDVKVE
AHS----------------G--------AQSGGGLE---AKA------------------
-----------------KALFSI-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------L----------------------------------
----------------KEQASAKMGRGGRVG-----------------------------
----------------------------LGS--------------GTRTLAPSLPCPGGR
GG---------GCHRKRARA-----------------------------------GGKAS
GKPKGKPKSKSTKPPA-A---------------------------AW----PARRVKFNF
PYKID--------DILGATDLQKVLNILERSNDPFIQEVALVTLGNNAAYTFNQ------
----------NAIRELGGVPIIAKMIKTKDPII------RE-KAYNALNNL-SVIAENQG
KIKTYISQVCDDTVICRLDSAVQMAGLRLLTNMTVTNHYQHLLSYSFPDF-FALLFLGNH
F-TK-IQIMKLIINFTENPAMTRELLSSK---VPSELISLFNKERDR----------EIL
LNILTIFENINDNIKSEGFASS---------RKEFSR--SSLFF-LFKESGVCVKKIKAL
A-NHSDLVVKVKVLKVLTKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
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-----------------------------------------------MSRARE--VGWMA
AGLM----IGAGACYCMYKLTI------------GR--EDDDQSEED----EEEEEEWDE
DDESEEDESEMWFDFPSTARPWSDDGDWTDPGAPDGNEARRSGGGKANRA--HPTRRRPF
PYGHK--------NAWGALSFKNTSCTLDLSKSPLIEIKVLFSQPKDAGFSRSQ------
----------DISSPLASFSTAGNTFLTPNPTV------EE-KTFCVPENV-NLSAEKQG
QIKMYISQVCLETVSRGYPSFLQQAGLNLLISMTAISH---MLAKSVSDMRFPFLSEESG
C-AK-AQVLKQLMNLSETPALAGGWLEAH---GLLSSLPLFIRNGNT----------ESL
LDALGP------------------------------------------------------
------------------------------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
---------------------------------MGGARDVGWVAAG----------LVLG
AGACYCIYRLT--RGQQR-GSG---------GRWLRP--SR-------------------
------------------------------------------SAE---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------DLT
SDSCD--------DVLNAEQLQKLLYLLESTDDPVIMERALVTLGNNAAFSANQ------
----------AVIRELGGIPIVGDKINNPNHSI------KE-KALNALNNL-SVNVENQI
KIKVYIKQICEDVFSGPLNSAVQLAGLRVLTNMTVTNDHQHMLKSYITDL-FQVLLTGNG
N-TK-VQVLKLLLNLSENPAMTEGLLSAQ---VDSSFLSLYDGHVAQ----------EIL
LRVLTLFQNINNCLRMEGQLAT---------QPPFSK--GSLFFLLYGE--ECAQKMRAL
V-YHHDVDVKEKALTIIPKF----------------------------------------
-------------------------------------------

------------------------------------------------------------
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---------------------------------MSRVRDAGCVAAG----------IVIG
AGTWYCVYKYA--RGRDQ-KKKRLV----KVKARA--VAGTGAKARAGLKAGFTIDLGSG
FGPPTPVLAETKNRATQDETSALDTAGAEGVVLAA------ASAEAQNGAGSQAQEANGA
--RDGSKA-ESAVPTAVSSETAPPSRDTEVP------------GATEAPTMPLAPKLAEA
PSE----------------A--------EAPI----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------AVPPEATEAVEAP
TAATPTEVVEAPKVAAP------------------------------SEVTETPRTTA-S
TRAAA-----------PPKAA-----------------E-AP------------------
----------------------GVSGASK-------------------------------
-----------SAAVPETAAAKRATPGAHTGAIPKAGS--ATGA---VPKGGA-------
-----------NGGNKSRSGG-K----GKGKG------------KKNKAEVDELGLGFRP
GD---------GVAVAAAASAN------------GGKAFLAEIPDS-----EEGESGWTD
TESESDSEPETQHRGRG----------------------------KR----PIPVTKRPF
PYEID--------EILGARDLRKVLTLLQKTDDPFIQQVALLTLSNNANYSCNQ------
----------DTIRKIGGLPIIANMINKTDPHI------KE-KALMVMNNL-SENYENQG
RLQVYMNKVMDDIMASNLNSAVQIVGLKFLTNMTITNDYQHLLVNSIANF-FRLLSQGGG
K-IK-VEILKILSNFAENPDMLKKLLSTQ---VPASFSSLYNSYVES----------EIL
INALTLFEIIYDSLRAEVFS-----------YREFNK--GSLFF-LCTASGVCVKKIRAL
A-NHHDLLVKVKVIKLVDKF----------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
-------MTGAEIEPSAQAKPEKKTGEEA--------VA-----------GAERENEVPL
VVRPKV--------------------------RTQTQVTSGAKSKTENKPVPGARPKTEA
------QAVAGA------------RPKN----------------------------EAQA
MPGARPKN----------------------------EAQTMAGARPKNE------AKAVG
GARPKT--EAKVIPGARPQDEA--------------Q--------------AWAQTEFA-
-----AEAMSQAEGVSQTNAVSWPLVSTES--GSVTKSKGLSIDRELANMDAETFPGSQ-
-AQKGIQPWFGPG-DEPT------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---MGSWCYPRPRAR-EEASNESGFWSADETSTVSSFWSGEETSIRSWPREEA---NTRS
RHRAKHQ-----T--NPRSRPRSKQEPYIDS-WSGSE-----------------------
-DEAGNPFCLWPGENTNNLF----------------------------------------
---------------------RPTVREEANVRSKLRTKREDC--FESESE------DEFY
KESWFLPGEEA---------NSR-----FRHRDKEEPNTILKSR----------------
AQ----KDVHNGDRVKQEPKF-----EEDVIIGSWFWAEKEA------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------NL
EAG------ASAICESEPGAE-----EGAI------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------GGSLFWAEEKS
SLGA--------------------------------------------------------
-----------------------------------------------VAREEARPES---
------------------------------------------------------------
------------------------------------------------------------
-EEEAIFGSWFWDRDEACFDL-NPSPVYRASNRFRDSAGVELNVSSRPQTWEEVTVEFKP
-GPC----HGIGFPSTTPFRIPEEAY-----KMFEANPKDTELSPEG----E--EQESVP
QPDQ--PDAEFPFQYDSSY--------------------RSVQEIREHLRAKASAEPENW
SCSCIQ-----CELKIGSEEFEELLLLREKIRDPFVHEISKIAMGMRSASQFTR------
----------DFIRDSGVVSLIETLLNYPSSRV------RT-SFLENMIHM-APPYPNLN
MIETFICQVCEETLAHGVNSLEQLTGIRMLRHLTVTTDYHVLIANYMSGF-LSLLTTANA
R-TK-FHVLKMLLNLSDNPAVAKKLFIWF---CVVTYI--FNADVKFVKLLFCAGSFCEC
QMNIRAVNAVVDI---CLLVQIV---------IFFSI--KLPM-S---------------
------------------------------------------------------------
-------------------------------------------

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---------------------------------------MTGTKN--KTRAQAKTEKK-P
ITQAKAGAEREATGV------VRPV---------------------AKTRAKAKAKTGSK
-----TDAV---------------------------------------------------
------AEMKAV-------------SKNKVVAEVKEGSLSEPKTLGRAM-----------
-----GDF----------------------------SPKAGNESTSSTCKNEAGIDAWFW
AGEE------------------------ATINSWFWNGEEAGN-SSST------------
---------KNDKP--------EIGAQVCA----E-------------------------
------------ELEPAAGADCKPRSGAEE------------------------------
EEEENVIGNWFWEGDDTSFDP-NPKPVSRIVKPQP---VYEINEKNRPKDWSEVTIWPNA
PAVTP---AVLGFRSQAPSEASPPS----YIVLASAEENACSLPGA------TACRPSRN
TRSCSQPIPECRFDSDPCI--------------------QTIDEIRRQIRIREVNGIKPF
ACPCKM------ECYMDSEEFEKLVSLLKSTTDPLIHKIARIAMGVHNVHPFAQ------
----------EFINEVGVVTLIESLLSFPSPEM-------RKKTVITL-NP-PSGDERQR
KIELHVKHMCKETVSFPLNSPGQQSGLKILGQLTTDFVHHYIVANYFSEL-FHLLSSGNC
K-TR-NLVLKLLLNMSENPTAARDMINMK---ALAALKLIFNQKEAK----------ANL
VSGVAIFINIKEHIRKGSIVVVD----------HLSY--STLM-AIFREVKGIIETM---
------------------------------------------------------------
-------------------------------------------

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-------MTGAEIEPGVQAKTGNKPGDENS--------N-----------AAERENAIPL
VVRPKV--------------------------RT--QLMPGARPKMKSKGTSGARSKS--
------------------------------------------------------------
------------------------------------------------E------PSTVG
GAHANG--KTKASSSSRSKSDA--------------Q--------------AWGQNKFR-
-----GESMSKMGKQCQTKAVDSPLVSADS--GAVPNAKCLYVDRESVHMDTERFPKK-A
TSQGRFQPSFGSE-EVTS------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---IGPWYCPRPIPK-EEVYENSDFKWGDKPSGGSWFWNRDEINTRFRPRKSMKV-SSRS
RHMAKQE-----A--NTMSRHKNKQEFYIIS-SSDSE-----------------------
-DESVKTSWFWTKEKTNIWS--RSREEP-NNRSWFRSKKDVCM------------ESSSE
SECESRMKSCFWSGEEAKPRSKPRVRKGANVRARHQAKRDAYSDVMSGAI------DINQ
KEAYFWPEEKT---------GTF-----LRSKPKKDTRVRAMAK----------------
EE----VKSKPGASTKQESRT-----EEEVLIGSWFWDTEES----------SPHVEDET
IVGNWFWTEEASAVT-GASHKP-RLRVKEKQIDSFCLRTE-KKISMEVGAKAASKSMLVA
NDD-EVIVGSWFWADDEDSK---------------------------------LQAEEET
IFGPWFWGIGDSN-VRS-VGVTCE-------------------------------SISR-
-SEEKSITDSWFWTGE-VNTE--IEEQ----------TRPASAKGTIFVPWFWSEKQAHM
DSG------TEACCDIMAGAE----EEEPIIGPWFWSKVDTGVEAEVNSKSSLEDEEE-P
IISPWFGAREQVSMKCAIGARCKLMAEVEDTSKRSCFWAEQQPCMYPLRRERLKPTLGQD
-----EDTVDSCLWSSNYTRPEALVG------------------------SWLWAAEEGN
IDDETGEEIKIPTLKDSMFKSWFWKENEEAIIKTIDRKESKPEAEEEDIIGSWFWAGEED
KHKTPGELKEENKKIAAKEEASVASWFWGKEEAV-RETGVCSKYSLKADE-EAIVGSWFW
EEETSLGAMGRDTFESNHGIKEE-----EVIGSWFWTEE-ANLESGSQA-DENRSETEDD
AIFEAILWAAKN-----DNIEARAHCVSKPEDD-DEMI----------------------
-VESWFWSSDKTIEESKTVTTCESKPENEEGLVVEFESGVKDE-MNSTGSGENCDLST--
-EAETIVGSWFWAGDEAHFES-DPIPVYRAICESTSSTEQEPDPSRRPQSWDEVTVQFKA
-GPW----GKAGFPFINPFRFPKET-ASLFAEMFGGKLKHMGLGPDG----E--GQLPLR
---H--SEDEFPFQYDPSY--------------------RSVQEIREHLKARESAQSESW
SCKCIQ-----CDLRIGPEEFEELLLLMDRNRDPFIHEISKIAMGMRSASQFTR------
----------DFIRNSGVVSLIEALLNYPSSRV------RT-QFLDNMVRM-APPYPDLN
MIQTYVCQVCEDTLDYNLNSSEQLAGLMMVRHLTTTTSYHELVATYITGF-LYLLATGNG
K-TK-FHVLKMLLNLSENLVMTKVLLRAE---AVSEFMGLLNKKERE----------DNV
QIVFEIFENIGNHLKKEEMFTDDDDDDDD--DDDCNY--EALV-STFREFEKFAKKMQNK
TDNQNHPEAE--------------------------------------------------
-------------------------------------------

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---------------------------------------MTGSKN--KARAQAKLDKR-A
SAQARALAEREAANA------GRAG---------------------GKHRDKAKARAGGK
-----TDAQ---------------------------------------------------
------AEMKAG-------------YKGKAAAEMKEGMRSEFKAQGKD------------
-------F----------------------------NHKAEYKGAKSTRKEKAASDTWFW
AGED------------------------SGINSWFWKGEEVSY-SSVA------------
---------KCENK-------TNTGTQGRT----E-------------------------
------------ESEPTHRASHRSRSGAEE------------------------------
EEEENVIGNWFWEGDDTSFDP-DPKPVFRIVKPQP---VDEINEKNRPKDWSEVTIWPKA
PAVTP---AVLGYRSQDSSESRPSS----YIVLASNEEETST------------TASTKN
ARSNQQPIPEYPFGSDPCI--------------------QTLDEIRQQIKIREMNGIKPF
ACPCKM------ECYLDSPEFEKLVNILKSTTDPLIHKIAQIAMGIHKVHPFAR------
----------EFINEVGVVTLIESLLSFSSPET-------RKKTVITM-N--SSGDERQH
KVEFHVKHMCKETVSFPLNSPGQQSGLKIIAQLTTESVHHYIVASYFSEF-FHLLSQGNR
K-TR-NLVLKVFLNMSENPKAARDMINMK---ALAALKLIFNQKEAK----------ANL
VSAVAIFINIKEHIRKGSIVVVD----------HLSY--STLT-AIFREVKGIIERM---
------------------------------------------------------------
-------------------------------------------

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-----------------------------------------------MGRARE--VGWVA
AGLM----IGAGACYCVYKLTI------------GR--DDSDKLEE------EEEEEWEN
D-ELDEEEPDIWFDLTTITRPWSEDGDWTEPGAPGGTEDRPSGGGKANRA--HPIKQRPF
PYEHK--------NTWSAQNFKNGSCILDLSKSLFIQGKMFFAESKNVCFSFSH------
----------DINSPLASLSMVGNMIPTPDPTV------G--EALCAPDNL-NASIEKQG
QIKMYLIEVCRETVLRCCNSFLQQAGLNLLISMTVINN---MLAKSVSDLKFPLISEESG
C-AK-VQLLKPLMGLSEKPVLAGELLSAQ---MLLSSVTLFIRNGNR----------EMP
VETLAL------------------------------------------------------
------------------------------------------------------------
-------------------------------------------

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------------------------------------------------------------
-------MTGAEIEPCTQAKSEKKAGEEVG--------S-----------GAERETEVPL
VVRPKV--------------------------RTQAQVMTGAQPKTKAKAMTGAWPRSEA
------QAISGARP----------------------------------------------
-----PKT----------------------------EA------------------MAIA
GAWPKT--EVIATAG------------------------------------AWRKT-EG-
-----LATMSETEEVTQTNAIAWPLVSTES--RLVAKTKALSMDRELVDVEDDALSGTN-
-AQAGVQPWFGPG-EESN------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---MGSWCYPRPRAK-QEASDESGFWSADETSTMSPFWAGEETSIRSWPKEEA---SSRS
RHRAKQQ-----T--NTRSRPRMKQGPCIDS-RSGSE-----------------------
-DEAGNLYSLWAGENTNILS----------------------------------------
---------------------RPRAREEANIRSKLRTKREDC--FESGSE------GI--
----LVLPEEA---------NSR-----FRPRDRKE-NTSLKPR----------------
AQ----KDANNRDRVKQEPRS-----EEEVIIGSWFWAEKEA------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------SM
GAG------AVASYESMPGAG-----EGAI------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------LGSLLWTEDEA
TAGA--------------------------------------------------------
-----------------------------------------------GAREMARPES---
------------------------------------------------------------
------------------------------------------------------------
-E-EAIFGSWFWDRDEACFDL-NPSPVYKASCRFSGLAEQEINVLSRPKSWEEVNVEFKP
-VPC----HGLGFPSISPFKIPEEAI-AELSEMTEGNLKQIEQNPEG----E--EQESLL
QPNQNEPDPVFPFQYEPSY--------------------LSVEEIRQHLKAKECAEPGSW
LCKCVQ-----CELRIGSEEFEELLLLMDKIQDPFIQEISKIAMGTKSASQCTR------
----------DFIRDSGVVSLIETLLNYPSSRD------RS-RFLENLIHM-APPHPNRN
MIETFICQVCEETLVRNLDSPEQLSGIKIVRDLTATTDYHTLVASYISGF-LSLLGTGNR
K-TR-FHILKVLLNLSENPNVAKKVFSAK---ALSIFVGLFNVKETN----------DNI
KIVIKMFQNMSNNIKKGVMCSID--------DDEFSL--EPLV-SAFHELEALAKELEAQ
INSRKGRRVGK-------------------------------------------------
-------------------------------------------

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------------------------------------------------------------
---------------------------------MGRALEAGWV-AG----------LVLG
AGACYCVPWLV--S--------------------VCS--R--------------------
------------------------------------------------------------
------------------------------------------------------------
--R----------------G--------PRLGG-MR---EG-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------DV-------------------------------
------------------QGS-F----HLGI--------------SNFF-GYVLSK--KT
RP---------------STHNG------------WQPSNN--------------------
-----------QQTYQ-------------------------------------QAILIDA
SFSDL--------YTLNTQCLKKIICLLESTEDPLIRERALITLGNCAAFSVNQ------
----------DIIRNLDGLSVIGNMLKDPNPKV------KE-KALNALNNL-SMNIQNQR
ELKVYISQICEETISSPLNSEVQLAGLRLLTNMTVTNDYQHLIANSVSDL-FGLLSLGNE
N-IK-IQTLKVLLNLSANPAMTRELLSVQV---PSSLISLLDGKMEK----------EIL
LRVLTLFANLNDNIKQKENSFA---------QLQFNN--GSLFSLFYGESTECTEKLLSL
A-CHHDINVKEKVAKILTIL----------------------------------------
-------------------------------------------

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------------------------------------------------------------
------------------------------GKGRGGPEVGLKAG--------IRGP----
------ANTKAKAKIQAKAVA-----EAELKTGLV----TQAKAGDRAVAR--TVTYAEA
--MALTRRVSKM------------------------------------------------
------------------------------------------------------------
-----------ESKTKTRVMAETKATPLT-EPSVVSQTKSKAMPMSRL--SAVTHYKVKA
G-----------------------------------------------------------
-------AGREANIGS-----------KDNIGSRSQR-----------------------
--------RSKAS-----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------IKL-----------------------------KFSDEDGKNVCSWFW
TGEE------------------------PSVGSWFWPKEDNPFQV---------------
-----YKPPAK---------------------I-QEMP----------------------
------------------------------------------------------------
----------------------KPTPK------------------------PELTVKQKA
-KAW----SRA--RFCVLVPVD------------GG--EQS-LPP---------GGNWTL
VDTLIET--------PLGIRPLTKIPPCNGPYFQTLAE------LKNQVKCREKYRPNPK
TCRCKS-----HVFSLEPKEFDKLVALLKLTRDPFIHEIATMIMGISPAYPFTQ------
----------DIIHDVGITVMIENLVNNPNVNE------HP-RTLNMVDDS-SEFSGEPQ
IGELYINQVCRDIIAYPLNSTMQLDGLKLLVQLSVRFEYHHIILNYILDF-LTLLNKGSV
K-TK-LYVLKVCLHLSKNQANTRELISAK---VLSSLVAPFNKNESK----------ASI
LNIIEIFENINFQFKKKVKLFTK--------EE-FTK--YELI-SIFEGAKEFGQKLQDL
A-EHSDPEVRDKVIRLILKL----------------------------------------
-------------------------------------------

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---------------------------------MGRTREAGCLAAG----------VVIG
AGACYCVYRLT--WGRDE-SEKIWD----DHDDDDEE--ESSD-----------------
------------------------------IAETG------KGAKANAGAGAGARL-QGD
--S--------------------------KA------------KAEVSVELRSGSNVKAE
AHL----------------K--------AQSGGGLE---AKA------------------
-----------------KALFST-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------L----------------------------------
----------------KEQASAKAGKGARLGTIS--------------------------
---------------------------------------------GTRTLTPGLPCPGVR
GG---------GCHPVRNGART---------------------------------GGRTS
GKSKGRTRGKSARTPA-T---------------------------SW----PVRRGKFNF
PYKID--------DILGATDLQKVLNILERTSDPFIQEVALVTLGNNAAYSFNQ------
----------NAIRELGGLPIIAKLIKTKDPII------RE-KAYNALNNL-SVNAENQG
KIKTYISQVCDDTMICRLDSAVQMAGLRLLTNMTVTNHYQHLLSYSFPDF-FALLFLGNY
F-TK-IQIMKLIINFTENPAMTRELVSCK---VPSELISLFNKEWDR----------EIL
LNILTLFENINDNIKNEGLASS---------RKEFSR--SSLFF-LFKESGVCVKKIKAL
A-NHSDLVVKVKVLKVLTKL----------------------------------------
-------------------------------------------

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---------------------------------------MAGTKN--KTRAQAKTEKK-A
AIQAKAGAEREATGV------VRPV---------------------AKTRAKAKAKTGSK
-----TDAV---------------------------------------------------
------AEMKAV-------------SKNKVVAETKEGALSEPKTLGKAM-----------
-----VDF----------------------------TPKAGNESTSSTCKNEAGTDAWFW
AGEE------------------------ATINSWFWNGEEAGN-SFST------------
---------KNDKP--------EIGAQVCA----E-------------------------
------------ELEPAAGADCKPRSGAEE------------------------------
EEEENVIGNWFWEGDDTSFDP-NPKPVSRIVKPQP---VYEINEKNRPKDWSEVTIWPNA
PAVTP---AVLGFRSQAPSETSPPS----YIVLASAEENACSLPVA------TACRPSRN
TRSCSQPIPECRFDSDPCI--------------------QTIDEIRRQIRIREVDGIKPF
ACPCKM------ECYMDSEEFEKLVSLLKSTTDPLIHKIARIAMGVHNVHPFAQ------
----------EFINEVGVVTLIESLLSFPSPEM-------RKKTVITL-NP-PSGDERQR
KIELHVKHMCKETMSFPLNSPGQQSGLKILGQLTTDFVHHYIVANYFSEL-FHLLSSGNC
K-TR-NLVLKLLLNMSENPTAARDMINMK---ALAALKLIFNQKEAK----------ANL
VSGVAIFINIKEHIRKGSIVVVD----------HLSY--NTLM-AIFREVKEIIETM---
------------------------------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
-------MTGAEVEPVAQAKPEKKPGEEVV--------G-----------GAERETEVPM
VVRPKV--------------------------RNQA--TSGARSKTESKA----------
--------TAGARPKTESQTMAGARPRT----------------------------ESQP
MAGARPKT----------------------------EFQAMPGARPKTE------ARAVG
RARPKT--EAKAIPGARPKDEA--------------Q--------------VWAQTEFG-
-----AEAMLQSEGMPQTSVVAWPLVNTES--GSVTKPMALSVDRELVNVDSETFPSSQ-
-VQTGIQPWFGSG-EETS------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---MGSWCYPRAKAR-EEASSESGFWSADETSTMSSFWAGEEASIRSWPREEA---NTRS
RHRAKHQ-----P--NPRSRPRSKQDPFIDS-WSGSE-----------------------
-EESGNPFCLWAGENTNNLF----------------------------------------
---------------------RSRVRDEANMRSKLRTKREDF--FESESE------DEYY
KESWFLPEEEA---------NSR-----FRPRDKEAPNTVLKPR----------------
TQ----KVVNNSDRVKQETRF-----EEEVIIGSWFWAEKEA------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------SM
EAG------ASAICESEAGAE-----EGAI------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------GGSLFWTEENS
SLGA--------------------------------------------------------
-----------------------------------------------VAREETRPES---
------------------------------------------------------------
------------------------------------------------------------
-EEEAIFGSWFWDRDEACFDL-NPRPVYKASPRFRDGAEEEVNVSSRPKTWEEVTVEFKP
-GPC----HGVGFPSPSPFRIPEEATTSVYTELFEGKPKNVEVTPEG----E--EQESLL
QSDQ--PDSEFPFQYDPSY--------------------RSVREIREHLRAKESAQPESW
SCSCIQ-----CELKIGPEEFEELLLLMDKIRDPFIHEISKIAMGMRTASQFTR------
----------DFIRDSGVVSLIETLLNYPSSRV------RT-SFLENMIHM-APPYPNLN
MIETFVCQVCEETLAHSVGSPEQVLGLRMLRHLTSTTDYHTLVSNYMSGF-LSLLTTGNA
R-TK-FHILKMLLNLSENPMVAKKLF----------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------

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------------------------------------------------------------
-------MTGAEVEPGAQAKPEKKAGEMG--------MG-----------GPEREKEVPL
VVRPKV--------------------------RPQTQVTPGAKPKTESKSVPGARPKTES
------PAMAGS------------RPKS----------------------------EASA
MARARPKT----------------------------DPPKVARARPKTG------GKAVG
GARPKS--EAKATPGASPKDDA--------------L--------------AWSQTEFG-
-----AHAMSQSDGASQTNAVIWPLVSTDS--GSVTKSKGS-LDAEVVKVDTQSFSGTQ-
-GQTGLQPRFGQR-EETA------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---GGSWYYPRPRAR-EEASNESGLWSADETCAVSSLWAGEETSIRSLPREEA---NTRS
RHRAKHQ-----T--NPKSKPRSKQETYFDS-WSGSE-----------------------
-DEAGNPLCFGAGENTNNLL----------------------------------------
---------------------RSRVREETNIRSKLRTKREDC--FESESE------DEFY
KESWFLPGEET---------NSR-----FRPRDKEESNDTSKSR----------------
AQ----KGIKHNDRAEQEARY-----EEEVIIESWFWAEKEA------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------SL
EAG------AAAICDSESGAE-----EGAI------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------GGSLFWTEEKS
NLGA--------------------------------------------------------
-----------------------------------------------LAREEARPES---
------------------------------------------------------------
------------------------------------------------------------
-EEEAIFGSWFWDRDEACFDL-NPSPVYRANCRFRDAVEEEPSVSTRPQTWDEVTFQFKR
--PS----RAIGFPPITSFRIPEGSN-----EAIEANPKNL----EG----E--EEEFLF
EPDP--LETVFPFRYDPSY--------------------RSVQEIREHLKIKEGVEPEDW
FCSCIQ-----CELKIGAGEFEELLLLMDRIQDPFIQEISKIAMGMRSASQFTR------
----------DFIRDSGIVSLIETLLNYPSSRV------RT-SFLENMVHL-APPYPNLN
MIETFICQVCEETLAHGVDSLEQVTGIMMLRHLTMTTDYHTLIANYMSGF-LSLLTTGNA
R-TK-FHVLKMLLNLSENLKVAKKLFSAE---ALSVFVGLFNIEETN----------DNI
QIVIKMFQNISNIIRSGALAFID---------EDFSL--EPLI-SAFHEFEELAKQLQVQ
IDNQNDPEVGRQS-----------------------------------------------
-------------------------------------------

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------------------------------------------------------------
------------------------------------------------------------
---------------------------------MGRTREAGCVAAG----------VVIG
AGACYCVYRLA--WGRDE-NEKIWD----EDEESTDT--SE-------------------
-----------------------------IGVETV------KGAKTNVGAGSGAKLQGDS
-----------------------------KV------------KPEVSLGLEDCRGVKEK
AHS----------------G--------SHSGGGLE---AKA------------------
-----------------KALFNT-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------L----------------------------------
----------------KEQASAKAGKGARVGTIS--------------------------
---------------------------------------------GNRTLAPSLPCPGGR
GG---------GCHPTRSGSRA---------------------------------GGRAS
GKSKGKARSKSTRAPA-T---------------------------TW----PVRRGKFNF
PYKID--------DILSAPDLQKVLNILERTNDPFIQEVALVTLGNNAAYSFNQ------
----------NAIRELGGVPIIAKLIKTKDPII------RE-KTYNALNNL-SVNAENQG
KIKTYISQVCDDTMVCRLDSAVQMAGLRLLTNMTVTNHYQHLLSYSFPDF-FALLFLGNH
F-TK-IQIMKLIINFTENPAMTRELVSCK---VPSELISLFNKEWDR----------EIL
LNILTLFENINDNIKNEGLASS---------RKEFSR--SSLFF-LFKESGVCVKKIKAL
A-NHNDLVVKVKVLKVLTKL----------------------------------------
-------------------------------------------

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------------------------------------------------------------
---------------------------------MGYARKVGWVTAG----------LVIG
AGACYCIYRLT--RGRKQNKEK-MA----EGGSGDVD--DAG----------------DC
---------------------------------------------------------SGA
--RYNDWSDDD-------------------------------------------------
DDS----------------N--------E-------------------------------
------------------------------------------------------------
-SKSIVWYPPWAR-----------------------------------------------
------------------------------------IG----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------T--------------------------------
-----------EAGTRARARA---------------------------------------
------------------------------------------------------------
-------------RARAT---------------------------RA----RRAVQKRAS
PNSDD--------TILSPQELQKVLCLVEMSEKPYILEAALIALGNNAAYAFNR------
----------DIIRDLGGLPIVAKILNTRDPIV------KE-KALIVLNNL-SVNAENQR
RLKVYMNQVCDDTITSRLNSSVQLAGLRLLTNMTVTNEYQHMLANSISDF-FRLFSAGNE
E-TK-LQVLKLLLNLAENPAMTRELLRAQ---VPSSLGSLFNKKENK----------EVI
LKLLVIFENINDNFKWEENEPT---------QNQFGE--GSLFF-FLKEFQVCADKVLGI
E-SHHDFLVKVKVGKFMAKLAEHMFPKSQE------------------------------
-------------------------------------------

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-----------------------------------------------MGRARE--VGWMA
AGLM----IGAGACYCVYKLTI------------GR--DDSEKLEE------EEEEEWDD
DQELDEEEPDIWFDFETMARPWTEDGDWTEPGAPGGTEDRPSGGGKANRA--HPIKQRPF
PYEHK--------NTWSAQNCKNGNCVLDLSKCLFIQGKLLFAKPKDAGFPFSQ------
----------DINSHLASLSMARNTGPTPDPTV------R--EALCAPDNL-NASIESQG
QIKMYINEVCRETVSRCCNSFLQQAGLNLLISMTVINN---MLAKSVSDLKFPLISEGSG
C-AK-VQVLKPLMGLSEKPVLAGELVSAQ---MLFSFMSLFIRNGNR----------EIL
LETPAP------------------------------------------------------
------------------------------------------------------------
-------------------------------------------

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------------------------------------------------------------
---------------------------------MGRTREAGCVAAG----------VVIG
AGACYCVYRLA--WGRDE-NEKIWD----EDEESTDT--SE-------------------
-----------------------------IGVETV------KGAKTNVGAGSGAKLQGDS
-----------------------------KV------------KPEVNLGLEDCPGVKEK
AHS----------------G--------SHRGGGLE---AKA------------------
-----------------KALFNT-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------L----------------------------------
----------------KEQASAKAGKGARMGTIT--------------------------
---------------------------------------------GNRTLAPSLPCPGGR
GG---------GCHPTRSGSRA---------------------------------GGRAS
GKSKGKARSKSTRAPA-T---------------------------TW----PVRRGKFNF
PYKID--------DILSAPDLQKVLNILERTNDPFIQEVALVTLGNNAAYSFNQ------
----------NAIRELGGVPIIAKLIKTKDPII------RE-KTYNALNNL-SVNAENQG
KIKTYISQVCDDTMVCRLDSAVQMAGLRLLTNMTVTNHYQHLLSYSFPDF-FALLFLGNH
F-TK-IQIMKLIINFTENPAMTRELVSCK---VPSELISLFNKEWDR----------EIL
LNILTLFENINDNIKNEGLASS---------RKEFSR--SSLFF-LFKESGVCVKKIKAL
A-NHNDLVVKVKVLKVLTKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
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---------------------------------MSRVRDAGCVAAG----------IVIG
AGAWYCVYKYT--RGRDQ-TKKRMV----KPKNRA--VAGTGARARAGLRAGFTIDLGSG
FSPPTPVRAEAEDR-AQDEASALDAVGAEAVAPAA------SSAEAQSGAGSQAQEADGA
--GVGPKA-ESAAGAAMASSIAPPPGVTEAL------------GAAEAPAMAGAPKVVEA
PRE----------------A--------ETSRRA-VPPGTVVPTEA-AA-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------PTEVTEGPG------------VAAPT---------
---------KVA---EVP------------------------------------G-----
-VASPTEAAEAPVPATP------------------------------TG-----------
-------------------AA-----------------E-SP------------------
----------------------GTSGSPR-------------------------------
-----------TAVVPGTSAAKKATPGAHTGAIPKATS--ATGA---VPKGGA-------
-----------KGVTRSRNGG-K----GKGK-------------K-SKVEVDELGMGFRP
GD---------GVAAAAAASAN------------GGQAFLAEVPDS-----EEGESGWTD
TESDSDSEPETQRRGRG----------------------------RR----PVAVQKRPF
PYEID--------EILGVRDLRKVLALLQKSDDPFIQQVALLTLSNNANYSCNQ------
----------ETIRKLGGLPIIANMINKTDPHI------KE-KALMAMNNL-SENYENQG
RLQVYMNKVMDDIMASNLNSAVQVVGLKFLTNMTITNDYQHLLVNSIANF-FRLLSQGGG
K-IK-VEILKILSNFAENPDMLKKLLSTQ---VPASFSSLYNSYVES----------EIL
INALTLFEIIYDNLRAEVFN-----------YREFNK--GSLFY-LCTTSGVCVKKIRAL
A-NHHDLLVKVKVIKLVNKF----------------------------------------
-------------------------------------------

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------------------------------------------------------------
---------------------------------MGRTREAGCVAAG----------MVIG
AGACYCVYRLT--WGKDA-NEKIWD----DEEESSDI--SE-------------------
-----------------------------TGVEAE------QGAKTNVDVGAGVRPQSDT
-----------------------------KA------------KAEVRVGLESGLGVKKE
AHC----------------G--------SPSGGGLE---AKA------------------
-----------------KALFNT-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------L----------------------------------
----------------KEQASAKMGKGARVGNIS--------------------------
---------------------------------------------GNRTLASSLPCPGGR
GG---------SCHPSKSGARA---------------------------------GSRAN
GKSKGKSRSKSTRALP-T---------------------------TW----PVRRGKFNF
PYKID--------DILSTPDLQKVLNILERTNDPFIQEVALVTLGNNAAYSFNQ------
----------NAIRELGGVPVIAKLIKTKDPVI------RE-KTYNALNNL-SVNTENQG
KIKTYISQVCDDTMICRLDSAVQMAGLRLLTNMTVTNHYQHLLSYSFPDL-FALLFLGNH
F-TK-IQTMKLIINFTENPAMTRELVSCK---VPSELISLFNKEWDR----------EIL
LNILTVFENINDNIKTEGLASS---------RKEFSR--SSLFF-LFKESGVCVKKIRAL
A-SHNDLVVKVKVLKVLTKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
--------------------------------------------MGRIQEVGWVTAGLVI
WAGTCYYIYKFTKGRAQSVRTLARNGSTV-KMETVVG----VQSQTLAINEAE----IKT
KPQVEIGAETGARSGPGAEVETKAAAIAIHRANSQ----AKAMVGAEPETQSE-------
SKVVAGTLVMTEAVTLTEVK--AKAREVAMKEAVTQTDAEAGKIVKKEAVTQTK-AKAWA
LVAKTEAKREAMTQTKAETHILAEKETEINRVMVTQSETLAAPRE----VAKMGATNKTG
IVDETKTRALEETVSVAKTQSEARPGATVDARGNLNGMSREVAGVDMKSCAQSQAVTKIQ
GDDMPGTGVEDMGNCK---------------------------TMSRAESGADTRASAQP
QIFAKTQTEAIPGAKIDAGGNTNAMCKVGAGAD---------TVAKKQAEVTSGAR-VDG
RGNTNVISKAITGADMRAAAQPQAVASTHAEAMSDAKVKNRGNPNAMTKAGAKANLRANS
QVEALPDARDKSRGNPNAMAKVGDGTDMLSCT-QPQLVASVQADTLSDGKIKVRGNVNTM
PKEGAGVDMKAQ--GMAQSQGEALPNTRGKARGKA--------------------GVKTP
AEALLDS------------------------RPLVVANPQGEALPGAKNKVKGNPHTVLK
VGAGEGTTDSAQPEAV---------------------------------------VSFQG
EALLGTKNKVKGSPNVVLKAEVGAGAMGTAQLQIMASSKGEALLDSKNKVKGNSNAVSKA
GAGTDTTGSVQPQIVANSQGEVLPGAKNKVRGNPTTVPNSGVGPYT--------------
--------------------------TDCARPQAVANSQGEVLPGAKNKVKANLNAVSKA
EAGMGAT-----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------GSVQPQAVANSHCETLPGAKN-
---------------------------------------KVKGNPNVVSKAGAREDTVGS
TQPQVLASSQRETLPGARNKVKGNSNVVSK-----AGAREDTMGSAQPQVVANSQRETLP
GARNKVKGNSNAISKAEAGAGIMGSVQVQVVASSQGEVLPGAKNKVRGN--SNAVPKAEA
GADTVGSAQPQAVANSQSETLLGARNKVKGNTIAVPKAGTGAGTRHSAQPQIVAGSQ---
-------------------------------------GETLPGARDKSMSTSEAEATAED
EAYAKPE--AEAMPTSESEGGSGTQACRKTQPNIHDYYWNGIGVEDWIAAERWIKFRFQT
MDGDWENSVSWADDENEASIGSWSGA-SDK--AGIIRSWAVAC----DETSVKSWAGARA
ENVVGIGTWARAG-EQASGGLWAGGQTSEGTWAGD------------KASGGAWTGAENQ
ASGGSWALTGNQAIGELWAAGQASDGSWPGGQASGVSWVGEEAIGGSWTG--------AE
NQASEGSWAGA------------------------GAGNMSSVSYWAGVVDQAGG-GSWA
GT------------SDQSGGGSKPRFEDQASGEGSWAGAGGQASGGSMLGPEDQSSGRSW
ADTADQASGGSRLGHVDQSSGG--------------------------------------
----------AWAGTLDQSGGGSKPRFENQTTEEG-SWAGAGGQAGGGSKVGPEDQSSGR
SWANSGDQISGGFLVGIVDQANGGSWTGA----GHPASVGPKPIFEDQVSGRGSWA-DAG
EQVVGDSRLGLRDQSSGDSWAGTGDQASG------------WF-------------CVCP
G---SQ-TNGGSWGGASGQDVGGSRPGPMNQSSAGSWDSTGSQVSGSCWTGAGAVDQAGG
CSKPGFEDQAIGGGFWPGAGDQTGGGSRPGSEDQS--SGIGSWGVAGGQVL---------
------------------------------------GGARPGPADQSSGGSWAGTG---N
QSSGRSWIGPG--DQ-AVDCSKPEFEDQ-ACGGGSWAGAGSQASGESWAGSRPGNE----
---AIGG-----S--RM-----------------GSE-----------------------
--------------------------DQATGGSWARSEDQASGRFQVSFEVEANEGFWFG
PGAEAVIGSWCWTEEKADIVSRPDDKDEATTASRSGAGEEAIICSRIEAE------NKAS
SGSWIRSEEVA--------YMGSCVGAEAGA-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------GAEAGAEA-----------------------------GAGAGAESGAGVWSW
DGDA------------------------TTVESRLGAGEEAGV-----------------
---ESWTLARD------V-GEDELSRESSP-DI-EEIS----------------------
-LRSLFWAESENSNTFRSK--------SGKD--ANFESGAGDNT-SIKDKFEA-------
-AGGVDIGSWFCAGNENTSED-KSAPKAKAKKSSE-S----------RGIYPSM-VPGAG
MGSW----DGAMIWSETK--FA------------HQ--SEASFPVED----E-----SR-
KQ-T-----------------------------------RT------------GEKTRPW
SCRCKH------EANMDPRDLEKLICMIEMTEDPSVHEIANNALYNSADYSYSH------
----------EVVRNVGGISVIESLLNNPYPSV------RQ-KALNALNNI-SVAAENHR
KVKTYLNQVCEDTVTYPLNSNVQLAGLRLIRHLTITSEYQHMVTNYISEF-LRLLTVGSG
E-TK-DHVLGMLLNFSKNPSMTKDLLIAN---APTSLINIFSKKETK----------ENI
LNALSLFENINYHFKRRAKAFTQ--------DK-FSK--NSLY-FLFQRPKACAKKLRAL
AAECNDPEVKERVELLISKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
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---------------------------------MSRVRDAGCVAAG----------IVIG
AGAWYCVYKYT--RGRDQ-TKKRMA----KPKNRA--VTGTGARARAGLRAGFTIDLRPG
ISPPTPVRAVAEDG-VQDEVSAVDAVGAEAVAQPT------SNPEAHSEVGSQAQEATGA
--EVGPKA-ESVVGATEASTRAPPPGVAEAP------------APAEAPAMSGAPKVVAE
APS----------------A--------AEACRAVVPPGTVAPTEA-AT-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------PAEVAEPPE------------MAVPT---------
---------EVAEVAEVP------------------------------------I-----
-VVAPAEAAESPVPATP------------------------------T------------
------------------GAA-----------------E-TP------------------
----------------------GTCGSPK-------------------------------
-----------TTVVPGTAAAKKATPGAHTGAIPKAGS--ATGA---VPKGGA-------
-----------KGGNKSRNGG-K----GKGK-------------K-SKVEVDELGMGFRP
GD---------GAAAAAAASAN------------GGQAFLAQVPES-----EEGESGWTD
TESDSDSEPETQRRGKG----------------------------RR----PVQMQKRPF
PYEID--------EILGVRDLRKVLALLQKSDDPFIQQVALLTLSNNANYSCNQ------
----------ETIRKLGGLPIIANMINKTDPHI------KE-KALMAMNNL-SENYENQD
RLQVYMNKVMDDIMASNLNSAVQVVGLKFLTNMTITNDYQHLLVNSIANF-FRLLSQGGG
K-IK-VEILKILSNFAENPDMLKKLLGTQ---VPASFSSLYNSYVES----------EIL
INALTLFEIIYDNLRAEVFN-----------YREFNK--GSLFH-LCTTSGVCVKKIRAL
A-NHHDLLVKVKVIKLVNKF----------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
-------MTRAEIEPSAQAKPEKKAGEEV--------IA-----------GAERENDVPL
VVRPKV--------------------------RTQ--ATTGARPKTETKSVPGARPKTDA
------QAMSGA------------RPKT----------------------------EAQV
MGGARPKT----------------------------EAQGMAGARPKTD------ARAVG
GARPKT--DAKAISGTRPKDEA--------------Q--------------AWSQSEFG-
-----TEAVSQAEGVSQTNAVAWPLATAES--GSVNKSKGLSMDRELVDVDAETFPGTQ-
-GQKGIQPWFGPG-EETN------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---MGSWCYSRPRAR-EEASNESGFWSADETSTVSSFWAGEETSIRSWPREDS---NTRS
RHRAKHQ-----T--NPRSRPRSKQEAYVDS-WSGSE-----------------------
-DEAGNLFSFWAGENTSNLF----------------------------------------
---------------------RPRVREEANIRSKLRTNREDC--FESESE------DEFY
KQSWVLPGEEA---------NGR-----FRCRDKEDPNTALKPR----------------
VQ----KDV-DGDRVKQEPRF-----EEEVIIGSWFWAEKEA------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------SL
EGG------ASAICESEPGTE-----EGAI------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------GGSTYWAEEKS
SLGA--------------------------------------------------------
-----------------------------------------------VAREEAKPES---
------------------------------------------------------------
------------------------------------------------------------
-EEEAIFGSWFWDRDEACFDL-NPCPVYKVSDRFRDAA-EELNASSRPQTWEEVTVEFKP
-GLF----HGVGFRSTSPFRIPEEAS-----EILEAKPKNMELSPEG----E--EQESLL
QRNQ--PDPEFTFQYDPSY--------------------RSVREIREHLRARESAESEGW
SCSCIQ-----CELKIGSEEFEELLLLMDKIRDPFIHEISKIAMGMRSASQFTR------
----------DFIRDSGVVSLIETLLNYPSSRV------RT-SFLENMIHM-APPYPNLN
MIETFICQVCEETLAHSVDSLEQLTGIRMLRHLTMTIDYHTLIANYMSGF-LSLLTTANA
R-TK-FHVLKMLLNLSENPAVAKKLFSAK---ALSIFVGLFNIEETN----------DNI
QIVIKMFQNISNIIKSGKMSLID---------DDFSL--EPLI-SAFREFEELAKQLQAQ
IDNQNDPEVGQQS-----------------------------------------------
-------------------------------------------

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------------------------------------------------------------
---------------------------------MGRTREAGCVAAG----------MVIG
AGACYCVYRLT--WGKDE-NEKIWD----DDEESSDR--SE-------------------
-----------------------------IGVQTE------KGAKTNVDVKAGAKPQSDT
-----------------------------KA------------KAEVTLGLES--GIKKD
IHC----------------R--------AQSGGALE---AKA------------------
-----------------KALFNI-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------L----------------------------------
----------------KEQASAKIGKGARVGNIS--------------------------
---------------------------------------------GNRTLASSLPCPGGR
GG---------GCHPTKSGARA---------------------------------GSRAN
GKSKGKARSKNTKTTP-T---------------------------TW----PVRRGKFNF
PYKID--------DILSTPDLQKVLNILERTSDPFIQEVALVTLGNNAAYSFNQ------
----------NAIRELGGVPVIAKLIKTKDPII------RE-KTYNALNNL-SVNAENQG
KIKTYICQVCDDTMICRLDSAVQMAGLRLLTNMTVTNHYQHLLSYSFPDF-F--------
-----IQTMKLIINFTENPAMTRELVSCK---VPSELISLFNKEWDR----------EIL
LNILTLFENINDNIKSEGLASS---------RKEFSR--SSLFF-LFKESGVCVKKIRAL
A-SHNDLVVKVKVLKVLTKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
---------------------------------MSRVRDAGCVAAG----------IVIG
AGAWYCVYKYT--RGRDQ-TKKRMV----KPKNRA--VAGTGARARAGLRAGFTIDLGPG
FSPPTPVSAGTEDR-AQDEASALKAAGAEAVAPAA------SSIEVQSGAGSRAPEADGA
--RVGPKT-ESVVGAAVASAIAPPPGVAEAP------------AAAEAPVMTGTPKMAEA
PST----------------G--------EAPRAAAPPRTVVAAPI---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------EATEAPK------------VAAPTRV-------
--------------------------------------------------------AEAP
GVAVPPEAAEAPVPTMP------------------------------TG------T----
---AA-----------PTGAA-----------------E-VP------------------
----------------------GTSGSSR-------------------------------
-----------TAAVPGTAAAKKATPGAHTGAIPKAGS--ATGA---VPKGGA-------
-----------KGGTRSRNGG-K----GKGK-------------K-SKVEVDELGMGFRP
GD---------GAAAAAAASAN------------GGQAFLAEVPDS-----EEGESGWTD
TESDSDSEPETQRRGRG----------------------------KR----PVSMQRRPF
PYEID--------EILDVRDLRKVLALLQKSDDPFIQQVALLTLSNNANYSCNQ------
----------ETIRKLGGLPIIANMINKTDPHI------KE-KALMAMNNL-SENYENQG
RLQVYMNKVMDDIMASNLNSAVQVVGLKFLTNMTITNDYQHLLVNSIANF-FRLLSQGGG
K-IK-VEILKILSNFAENPDMLKKLLSTQ---VPASFNSLYNSYVES----------EIL
INALTLFEIIYDNLRAEVFN-----------YREFNK--GSLFY-LCTASGVCVKKIRAL
A-NHHDLLVKVKVIKLVNKF----------------------------------------
-------------------------------------------

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-----------------------------------------------MGRARE--MGWMA
AGLM----IGAGACYCMYKLTM------------GR--DEGNELEN------EEEDEWDD
EQDLDEEEADIWFDFTAMARPWSEDGEWDEPGAPGGTEDRRSGGGKANRA--HPTKQRPF
PYEHK--------NIWGVQSFQTFPCALNLTKCAFSQGKKMFTESTIAGFSLTH------
----------NVSRHLSSLSVVGSRSPTPQPTV------RE-KALDVPEHP-NSSIENQD
QIKMYIDEVCRDAVFCCCKSFLQQAGLGLLISMTVINN---MLAKSLSDPKFPLLSEGSG
C-AK-VQGLEAQMSLPEKPVLAEEVLAAQ---MLFSFMCLFTRSGSR----------EML
VEAISP------------------------------------------------------
------------------------------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
-------MTGAEIEAGTQAKSEIKTGEVVG--------D-----------GAEREVDVPL
VVRPKV--------------------------RSQAQSVTEAQLKTEDMALAGARPKTEG
------MAMAGARPKSEAITVAGARPKS----------------------------EFAA
VARAYPMT----------------------------EA----------M------AVTVA
GARPKT--EVKAILGTHSKDET--------------Q--------------TWAQIEPG-
-----AEERLKTEGITHSNVLPWPMVGSES--GPAAKTNSLCMDRELGNVEVEVLHGPKV
QSQAGIQPWFGSG-VETN------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---MGSWCYPSPKPQ-EETTNESGFWSADETSGVSFLGAGEETPIRSWPKDEA---STRS
RHRAKQQ-----S--NTRSRPKMKQEPYIDS-GSGSE-----------------------
-EEAGNAYCLWAGKNSNSLS----------------------------------------
---------------------RPRAREEANIKSKPRTKREDC--FESGTE------DDFY
KESWFLSGEAA---------NNR-----FRLRDKEEPKTNWKPM----------------
AL----KDVNNWDRVKQDPRC-----EEEVIIGSWFWGEKET------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------TL
EAG------AVAICESRPGSE-----EGAV------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------APSLLWTEEET
GMGA--------------------------------------------------------
-----------------------------------------------GAGEETRPES---
------------------------------------------------------------
------------------------------------------------------------
-EEEALFGTWFWDRDEPSFDL-NPTPVYKVGCRFRDLAEQEINASSRPQSWEEVTVEFKP
-IPC----HGVGFPSTSSFRVPEEA-ESVFSEIFGEKPTNVEVSPEG----E--EQESLL
QPNQ--PGPVFPFQYDSSY--------------------RSVREIREHLKAKGSAEPESW
SCSCIQ-----CELRIGSEEFEELLLLMDKIRDPFIHEISKIAMGTRSASQFTR------
----------DFIRDSGVVSLIETLLNYPSSRV------RT-SFLENMITM-APPYPNLN
MIETFICQVCEETFIHSLDSPEQMLGIRMVRHFTTTTDYHTLVANYMSEF-LSLLTTGNR
R-TK-FHVLKMLLNLSENPIMANKLFSAK---ALSIFIGLFNIEESN----------DNI
QIVIKIFQNMSNNIKKGVMSLID---------DDFSL--EPLI-SAFHEFEKLAKELQIQ
IDNQNDPEVGQ-------------------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------MGRARE--MGWMA
AGLM----IGAGACYCVYKLTV------------GK--DDNDKP-E------EEEDEWGD
DQELDDDEPKIWFNFTAMARPWNEDRDWTEPGAPGGTEDRPSGGGKANRA--HPMRQRPF
PYEHK--------NTWSAQSFKNISYTFELSRYPPIPGRLLFSEPKDAAFSQSC------
----------DVHRHSASPSVTGSSTPTPHPTG------ER-KALCAPDHL-NGSIENRG
QIKMYADEVCRETVSPCCNSFLQQAGLNLLISMTVINN---MLAKSASDLKFPLLSEGSG
C-AQ-VQLWKLLKGLSEKPVLAGQLLGVQ---VLFPVRI--NRSGNR----------ELL
LEMLTT------------------------------------------------------
------------------------------------------------------------
-------------------------------------------

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------------------------------------------------------------
---------------------------------------------------------DLT
DGSYD--------EVLNAEQLQKLLYLLETTEDAVIIEKALVTLGNNAAFSANQ------
----------AIIRELGGIPIVGNMINNANHSI------KE-KALNALNNL-SVNVENQS
KIKIYMNQVCEDVFSDPLDSAVQLAGLRLLTNMTVTNDYQPMLNSYITDL-FHVLLIGNG
T-TK-VQVLKLLLNLSENPAMTEGLLSAQ---VDSSFLALYDSHVAK----------EIL
LRALTLYQNINNCLKVDGRLAC---------QPTFTK--GSLFFLFYGE--ECAQKMRAL
A-NHPDADVKEKAVIMKC------------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
-----------------------MIGSTTKAKGREESGASLKPG--------SKSL----
------ANAKEKAKSQTKKVV-----EAKPKEELG----TQAEARDEAMARTQTVTHTEP
--ETMTWKVKKK------------------------------------------------
------------------------------------------------------------
-----------KDKTNTRVKDQTKTELRA-EPGLVPHTKADDLPMSVV--ITVTKSEIRV
D-----------------------------------------------------------
-------TGIETSIKYSSKAS-----DKGSMKHISEI-----------------------
--------KKETLVRSG----------A--------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------GDKASIVI-----------------------------NTTDEDEEYVCSWFW
TGEE------------------------PSVGSWFWPKEETPLQV---------------
-----YQPPPK---------------------V-EEEP----------------------
------------------------------------------------------------
----------------------EP-TD-----------------------NFDFTLKRKA
-AAW----ARG--RFIVLVPVE------------EF--EQS-LPP---------EGNWTL
VATLIET--------PLGIRPLTKIPPFEGPYFQTLAE------IKNQIREREKYGPNPK
TCRCKS-----RTFSLEPIEFDKLVALLKLTRDPFIHEIATMIMGISPAYPFTQ------
----------DIVHDVGITVMIENFVNNPNAKN------HS-RTVNVS-AS-ADTSEEAK
ENEAHVDKVCRDILSCPLNCSVQVEELKLLASLSMKFENHHVIINYVRHF-ITLLSKGSV
K-LK-FQILRVILYLSKNQANTRELISAE---VLSSLVALFHKNESK----------ANV
LHIINIFENINFQFKKRAKLFTK--------EM-FTK--SELI-SIFQEAKQFDLKLQDL
I-DHSDPEVRDKIIRLILKL----------------------------------------
-------------------------------------------

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---------------------------------MSRVRDAGCVAAG----------IVIG
AGAWYCVHKYT--RGRDQ-KKRRLA----KPKNQA--VAGTGARARAGPRAGFTIDLGPG
FNPPTTVYAGAEDK-VQDEAPALDMAGAEAVAPAS------SSTEARSEAESLAQKADGA
--GIGPKT-ELVVGAAVTSAMAQPLGVAKAP------------TALEGSAVAEASKVAEA
PRT----------------A----------------------------------------
------------------------------------------------------------
-----------------------------------------------------------E
APRAT----------VPPEVE---MPPKA-------------------------------
-------------------------------------------AMSP----RAA------
------------------------------------------------------------
--------------------------------------VLPPGKAVSTKATAATETVEAP
GEAAPIEVAECPGMTTL------------------------------GEVAETPVSTT-P
AGAAI-----------TARAA-----------------E-IP------------------
----------------------GTSGSTR-------------------------------
-----------TA-----AVNKKATPGAHTGAIPKAGS--ATGA---VPKGGA-------
-----------KGGTRSQTGG-K----G--KS------------KKSKAEVDELGMGFCP
GD---------GAAAAAAASAN------------GGYAFLAEVPDS-----EEGESGWTD
TESDSDSEPETQHRGRG----------------------------KK----TVPMQKSPF
PYEID--------EILGVRDLRKVLALLQKSDDPFIQQVALLTLSNNANYSCNQ------
----------ETIRKLGGLPIIANMINKTDPHI------KE-KALMAMNNL-SENYENQG
RLQVYMNKVMDDIMASNLNSAVQVVGLKFLTNMTITNDYQHLLVNSIANF-FRLLSQGGG
K-IK-VEILKILSNFAENPDMLKKLLSTQ---VPSSFSSLYNSYVES----------EIL
INALTLFEIIYDNLRAEVYN-----------YREFNK--GSLFY-LCTASGVCVKKIRAL
A-NHHDLLVKVKVIKLVNKF----------------------------------------
-------------------------------------------

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---------------------------------MGGARDVGWVAAG----------LVLG
AGACYCIYRLT--RGRRR-GG---------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
------------------RGLR------------LRPSR---------------------
--------------SA-------------------------------------E---DLT
NGSYD--------DVLNAEQLQKLLYLLESTEDPVIIERALVTVGNNAAFSVNQ------
----------AIIRELGGIPIVGNKINSPDPNI------KE-KALNALNNL-SVNVENQI
KIKIYINQVCEDVFSGSLNSAVQLAGLRLLTNMTVTNDHQHMFQSYITDL-FQVLLTGNG
N-TK-VQVLKLLLNLSENPAMTEGLLGAQVNSVDSSFLSLYDGHVAK----------EIL
LRVLTLFQNINNCLKMEGHLAV---------QPTFTN--GSLFFLLYGE--ECAQKIRAL
V-HHHDAEVKEKAVTMIPTI----------------------------------------
-------------------------------------------

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---------------------------------MSRVRDAGCVAAG----------IVIG
ASAWYCVYKYA--RGRNQ-TKKRMA----KPRTRA--VAGNGARARAGPRAGFTIDLGPG
FGPPTPVRTRTEDR-AQDEASALEAAGDEAVAPAA------ASAEAQSGAGNQVQEAEGA
--GVGSKA-EPVARATAPSSMAPPPGEAEAS------------VAAEAPTVARAPNSPEA
PGT----------------A--------EAAGVPMVPPRAPAPTEA-AA-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------STEAAEAPV------------PTMPP---------
---------AATVPS---------------------------------------------
------------------------------------------------G-----AT----
----V-----------PTGAA-----------------E-AP------------------
----------------------GTSGYPR-------------------------------
-----------TAA-----SSKKATPGAHTGAIPKAGS--VAGA---VPKGGA-------
-------K-----ATRSRTGG-K----GKGK-------------K-NKVEVDELGLGFRP
GD---------GAAAAAAASAN------------GGQAFLAEVPDS-----EEGESGWTD
TESESDSEPETQQRGRGG---------------------------RR----PVPMQKRPF
PYEID--------EILGVRDLRKVLALLQKSDDPFIQQVALLTLSNNANYSCNQ------
----------DTIRKLGGLPIIANMINKTDPHI------KE-KALMAMNNL-SENYENQG
RLQVYMNKVMDDIMASNLNSAVQVVGLKFLTNMTITNDYQHLLVNSIANF-FRLLSQGGG
K-IK-VEILKILSNFAENPDMLKKLLSTQ---VPSSFSSLYNSYVES----------EIL
INALTLFEIIYDNLRAEVFN-----------YREFNK--GSLFY-LCTTSGVCVKKIRAL
A-DHHDLLVKVKVIKLVDKF----------------------------------------
-------------------------------------------

------------------------------------------------------------
--------------------------------------------MGRTQEVGWVTAGLVI
WAGTCYYIYKFTKGRAQSVRTLARNGSTV-KMETVVG----VQSQTLAKSEAE----IKT
KPQAEIGAETGTRGGPGAEVETKGTAIARHRANSQ----AKTMVEAEAETQSE-------
SKVVAGTLVMTEAVTLTEVK--AKAREVAMKEAVTQTDAEAGKIVKKEAVTQTK-AKAWA
LIAKTEAKREAMTQTKAETHILAEKETEINRVMVTQSETLAVPKE----VVKMGATNKTG
IVDETKTRALEETVSVAKTQSEAWPGATVDARGNPNGMSREVAGVDVKSCAQSQAVTKIK
GDDMPGAGIEDMGNCK---------------------------TMSRAESGEDTRASAQP
QIVAKTQTEAIPGAKVDAGNNANAMCKVGAGADVRACV-QPQTVVKKQAEVTSGAG-VDG
RGNTNDISKAITGADMRAAAQPQAVASAQAEAMSDAKVKDRGNPNAMTKAGARANLRANS
QVEALPDARDKSRGNPNVIAKAGDGTDMLSCT-QPQLVASVQANTLSDGRIKVKGNVNTM
PKEGAGVDMKAQ--GMAQSQGEALPNTRGKARGKAKAKCKTGSGMDMKTCTQPQTGVKTP
AEALLDSRVDGRGNPNATSKAGTKADQRACGQPLVVANPQGEALPGAKNKVKGNPHAVLK
VGAGEGTADSAQPQAV---------------------------------------VSFQG
EALLGTKNKVKGNPNVVLKAEVGAGAMGTAQLQIEASSKGEALLDSKNTVKGNSNAVSKA
GAGTDTTGSVQPQIVANSQGEVLPGAKNKFRGNSTTVPNSGVGPYT--------------
--------------------------TDSAPPQAVANSQGEVLPGAKNKVKANLNALSKA
EAGMGAT-----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------GSVQSQAVANAHCETLPGAKNK
VRGNWNAVSKAGAGMDTRGSAQTQAVANSQGEVLPGARNKVKGNPNVVSKAGAKEDTMGS
AQPQVVANSQRETLPGARNKVKGNPNVVSK-----AGAKEDTMGSAQPQVVANSQRETLP
GARNKAKGNSNAISKAEAGAGIMGSVQVQVVASSQGEVLPAAKNKVRGN--SNAVPKAEA
GADTVGSAQPQAVANSQSETLLGARNKVKGSTNTVSKAGTGAGTRHSAQPQIVAGSQ---
-------------------------------------GETLPGARDKAMPSSEAETTAED
EVYAKPE--AQAMPISESEGGSGTQACRKTQLNIHDYYWNGIGVEDWIAAERWIKFRFQT
MDGDWENSVSWADDENEASIGSWSGA-SDK--AGIIRSWAVAC----DEASVKSWAGARA
ENEVGIGTWARAG-EQASGGLWAGGQPSEGTWAGD------------KASGGAWTGAENQ
ASGGSWVLAGNQAIGELWAVGQASNGSWPGGQASGVSWVGAEAIGGSWTG--------AE
NQASGGSWAGA------------------------GAGNMSSVSYWAGVVDQASG-GSWA
GT------------SDQSGGGSKPRFEDQASGEGSWAGAGDQASGGSRLGPEDQSSGRSW
ADTADQASGGSRLGHVDQSSGG--------------------------------------
----------SWAGTLDQSGGGSKPIFENQTTEEG-SWAGAGGQAGGGSKVGSEDQSSGR
SWANSGDQISGGFLVGVVDQANGGSWTGA----GHPASGGPKPIFEDQASGRGSWA-DAG
DQVVGDSRLGLRDQSSGDSWAGTGDQASG------------WF-------------CVCP
G---SQ-TNGGSWGGASGQDVGGSRPGPTNQSSAGSWDSPGSQVSGSSWTGAGAVDQVGG
CSKPGFEDQAIGGGFWPGPGDQTGGGSRPGSEDQS--SGIGSWGVAGGQVL---------
------------------------------------GGARP--ADQSSGGSWAGTG---N
QVSGRSWIGPG--NQ-AGDCSKPEFEDQ-ACGGSSWAGAGSQASGESWAGSTPGNE----
---ATGG-----S--RM-----------------GSE-----------------------
--------------------------DQATGGSWARSEDQASGRFQVSVEVEANEGFWFG
PGAEAVIGSWCWTEAKADIVSKPDDKDEATTASRSEAGEEAIICSRTEAE------NKAS
SGSWIRSEEVA--------YMGSCVGAEAEAE------------------AGAEAG--AE
AG----------------AG----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-AEAVAEAEAEAGA-------------------------------GAGAGAEAGAGVWSW
DGDA------------------------TTVESRLGAGEEAGV-----------------
---ESWTLARD------V-GEDELSRESSP-DI-EEIS----------------------
-LRSLFWAESENSNTFRSK--------SGKD--ANFDSGAGDNT-SIEDKFEA-------
-AGGVDIGSWFCDGNENTNED-KSASKARAKKSSE-S----------RGTYPSM-VPGAG
MGSW----DGAMIWSETK--FP------------HQ--SEASFPVED----E-----SR-
KQ-T-----------------------------------RT------------GEKPRPW
SCRCKR------EANMDPRDLEKLICMIEMTEDPSVHEIANNALYNSADYPYSH------
----------EAVRNVGGISVIESLLNNPYPSV------RQ-KALNALNNI-SVAAENHR
KVKTYLNQVCEDTVTYPLNSNVQLAGLRLIRHLTITSEYQHMVTNYISEF-LRLLTVGSG
E-TK-DHVLGMLLNFSKNPSMTKDLLIAN---APTSLINIFSKKETK----------ENI
LNALSLFENINYHFKRRAKAFTQ--------DK-FSK--NSLY-FLFQRPKACAKKLRAL
AAECNDPEVKERVELLISKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
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---------------------------------------------------------DLT
DGSYD--------DVLNAEQLQKLLYLLESTEDPVIIERALVTLGNNAAFSANQ------
----------AIIRELGGIPIVGNMINSPNHSI------KE-KALNALNNL-SVNVENQS
KIKIYMNQVCEDVFSDPLNSAVQLAGLRLLTNMTVTNDYQHMLNSYLTDL-FHVLLIGNG
S-TK-VQVLKLLVNLSENPAMTERLLSAQ---XXXXXXXXXXXXXXX----------XXX
XXXXXXXQNIHNCLKMH------L-------GQTFTK--GSLFSLFYGE--ECAQKMKAL
V-NHHDVDVKEKAVIMNC------------------------------------------
-------------------------------------------

------------------------------------------------------------
--------------------------------------------MGRIQEVGWVTAGLVI
WAGTCYYIYKFTKGRAQSVRTLARNGSTV-KMETVVG----VQSQTLAINEAE----IKT
KPQAEIGAETGARSGPGAEVETKATAIAIHRANSQ----AKAMVGAEPETQSE-------
SKVVAGTLVMTEAVTLTEVK--AKAREVAMKEAVTQTDAEAGKIVKKEAVTQTK-AKAWA
LVAKTEAKREAMTQTKAETHILAEKETEINRVMVTQSETLAVPRE----VAKMGATNKTG
IVDETKTRALEETVSVAKTQSEARPGATVDARGNPNSMSREVAGVDMKSCAQSQAVTKIQ
GDDMPGTGVEDMGNCK---------------------------TMSRAECGADTRASAQP
QIFAKTQTEAIPGAKIDAGGNTNAMCKVGAGADVRACI-QPQTVAKKQAEVTSGAR-VDG
RGNTNVISKAITGADMRAAAQPQAVASTHAEAMSDAKVKNRGNPNAMTKAGAKANLRANS
QVEALPDARDKSRGNPSVMAKVGDGTDMLSCT-QPQLVASVQADTLSDGKIKVRGNVNTM
PKEGAGVDMKAQ--GMAQSQGEALPNTRGKARGKAKAKCKTGAGMDMKTCTQPQAGVKTP
AEALLNSRVDGRGNPNATSKAGTKADQRVCGQPLVVANPQGEALPGAKNKVKGNPHTVLK
VGAGEGTTDSAQPEAV---------------------------------------VSFQG
EALLGTKNKVKGNPNVVLKAEVGAGAMGTAQLQIMASSKGEALLDSKNKVKGNSNAVSKA
GAGTDTTGSVQPQIVANSQGEVLPGVKNKVRGNPTTVPNSGVGPYT--------------
--------------------------TDSARPQAVANSQGEVLPGAKNKVKANLNAVSKA
EAGMGAT-----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------GSVQPQAVANSHCETLPGAKNK
VRGNWNAVSKAGAGMDTRGSAQPQAVANSQGEVLPGAKNKVKGNPNVVSKAGAREDTVGS
TQPQVLASSQRETLPGARNKVKGNSNVVSK-----AGAREDTMGSAQPQVVANSQHETLP
GARNKVKGNSNAISKAEAGAGIMGSVQVQVVASSQGEVLPGAKNKVRGN--SNAVPKAEA
GADTVGSAQPQAVANSQSETLLGARNKVKGNTIAVPKAGTGAGTRHSAQPQIVAGSQ---
-------------------------------------GETLPGARDKSMPTSEAEATAED
EAYAKPE--AEAMPTSESEGGSGTQACRKTQPNIHDYYWNGIGVEDWIAAERWIKFRFQT
MDGDWENSVSWADDENEASIGSWSGA-SDK--AGIIRSWAVAC----DETSVKSWAGARA
ENVVGIGTWARAG-EQASGGLWAGGQTSEGTWAGD------------KASGGAWTGAENQ
ASGGSWALAGNQAIGELWAAGQASDGSWPGGQASGVSWVGEEAIGGSWTG--------AE
NQASGGSWAGA------------------------GAGNMSSISYWAGVVDQAGG-GSWA
AT------------SDQSGGGSKPRFEDQASGEGSWAGAGGQASGGSMLGPEDQSSGRSW
ADTADQASGGSRLGHVDQSSGG--------------------------------------
----------AWAGTLDQSGGGSKPRFENHTTEEG-SWAGAGGQAGGGSKVGPEDQSSGR
SWANSGDQISGGFLVGIVDQANGGSWTGA----GHPASVGPKPIFEDQVSGRGSWA-DAG
EQVVGDSRLGLRDQSSGDSWAGTGDQASG------------WF-------------CVCP
G---SQ-TNGGSWGGASGQDVGGSRPGPTNQSSAGSWDSTGSQVSGSCWTGAGAVDQAGG
CSKPGFEDQAIGGGFWPGAGDQTGGGSRPGSEDQS--SGIGSWGVAGGQVL---------
------------------------------------GGARPGPADQSSGGSWAGTG---N
QSSGRSWIGPG--DQ-AGDCSKPEFEDQ-ACGGGSWAGAGSQASGESWAGSRPGNE----
---AIGG-----S--RM-----------------GSE-----------------------
--------------------------DQATGGSWARSEDQASGRFQVSFEVEANEGFWFG
PGAEAVIGSWCWTEEKADIVSRPDDKDEATTASRSGAVEEAIICSRIEAE------NKAS
SGSWIRSEEVA--------YMGSCVGAGAGAEA--------------GAEAGAEAG----
---------------------------------------------ARAGAE---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------AGAEAEAGA-----------------------------EAGPGAESGAGVWSW
DGDA------------------------TTVESRLGAGEEAGV-----------------
---ESWTLARD------V-GEDELSRESSP-DI-EEIS----------------------
-LRSLFWAESENSNTFRSK--------SGKD--ANFESGAGDNT-SIKDKFEA-------
-AGGVDIGSWFCAGNENTSED-KSAPKAKAKKSSE-S----------RGIYPSM-VPGAG
MGSW----DGAMIWSETK--FA------------HQ--SEASFPVED----E-----SR-
KQ-T-----------------------------------RT------------GEKTRPW
SCRCKH------EANMDPRDLEKLICMIEMTEDPSVHEIANNALYNSADYSYSH------
----------EVVRNVGGISVIESLLNNPYPSV------RQ-KALNALNNI-SVAAENHR
KVKTYLNQVCEDTVTYPLNSNVQLAGLRLIRHLTITSEYQHMVTNYISEF-LRLLTVGSG
E-TK-DHVLGMLLNFSKNPSMTKDLLIAN---APTSLINIFSKKETK----------ENI
LNALSLFENINYHFKRRAKAFTQ--------DK-FSK--NSLY-FLFQRPKACAKKLRAL
AAECNDPEVKERVELLISKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
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---------------------------------MSRVRDAGCVAAG----------IVIG
ASAWYCVYKYA--RGRNQ-TKKRLA----KPKTRA--VAGTGARSRAGLRAGFTIDLGPR
FGPPTPVHTQAEDR-AQDEASALDMAGPEGVAPAV------SSAEAQSGAGNQVQEVEGI
--WVGPKA-EPVVRATAASSMAPPPREAEAS------------VAVEAPTITRAPKLPEA
LDT----------------A--------EA------------------------------
----------------------PG--------------VLAAPPRVP-------------
V-----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------M------PPT-----------APAPTEAVEAP
VRATP------------------------------------------------TAAPV-P
SGVTV-----------PTGAA-----------------E-AP------------------
----------------------GTSGSPR-------------------------------
-----------IA------AYKKATPGAHTGAIPKAGS--ATGA---VPKGGA-------
-----------KG-TKSRTGG-K----G--KG------------KKNKVEVDELGLGFRP
GD---------GAAAAAAASAN------------GGQAFLAEIPDS-----EEGESGWTD
TESESDSEPETQQRGRG----------------------------RR----PVPMQKRPF
PYEID--------EILGVRDLRKVLALLQKSDDPFIQQVALLTLSNNANYSCNQ------
----------DTIRKLGGLPIIANMINKTDPHI------KE-KALMAMNNL-SENYENQG
RLQVYMNKVMDDIMASNLNSAVQVVGLKFLTNMTITNDYQHLLVNSIANF-FRLLSQGGG
K-IK-VEILKILSNFAENPDMLKKLLSTQ---VPSSFSSLYNSYVES----------EIL
INALTLFEIIYDNLRAEVFN-----------YREFNK--GSLFY-LCTTSGVCVKKIRAL
A-DHHDLLVKVKVIKLVDKF----------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MGYARKVGWVTAG----------LVIG
AGACYCIYRLT--RGRKQNKEK-MA----EGGSGDMD--DAG----------------DC
---------------------------------------------------------PGA
--RYNDWSDDD-------------------------------------------------
DDS----------------S--------D-------------------------------
------------------------------------------------------------
-SKGIVWYPPWAR-----------------------------------------------
------------------------------------IG----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------T--------------------------------
-----------EAGTRARARA---------------------------------------
------------------------------------------------------------
-------------RARAT---------------------------RA----RRAVQKRAS
PNSDD--------TVLSPQELQKVLCLVEMSEKPYILEAALIALGNNAAYAFNR------
----------DIIRDLGGLPIVAKILNTRDPIV------KE-KALIVLNNL-SVNAENQR
RLKIYMSQVCDDTITSRLNSSVQLAGLRLLTNMTVTNEYQHMFANSISDF-FRLFCTGNE
E-TK-FQVLKLLLNLAENPAMPRDLLRAQ---VPSSLSALFNRKENK----------EII
LKLLVIFENIVDHFKWEENEPT---------QNQFSE--GSLFF-FLKRFQMCADKILGI
E-SQHDFLVKVKVGKFMAKVAEHMILKNQE------------------------------
-------------------------------------------

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------------------------------------------------------------
---------------------------------MGRTREAGCVAAG----------VVIG
AGACYCVYRLA--WGRDE-NEKIWD----EDEESTDT--SE-------------------
-----------------------------IGVETV------KGAKTNVGAGSGAKLQGDS
-----------------------------KV------------KPEVSLGLEDCPGVKEK
AHS----------------G--------SHSGGGLE---AKA------------------
-----------------KALFNT-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------L----------------------------------
----------------KEQASAKAGKGARVGTIS--------------------------
---------------------------------------------GNRTLAPSLPCPGGR
GG---------GCHPTRSGSRA---------------------------------GSRAS
GKSKGKARSKSTRAPA-T---------------------------TW----PVRRGKFNF
PYKID--------DILSAPDLQKVLNILERTNDPFIQEVALVTLGNNAAYSFNQ------
----------NAIRELGGVPIIAKLIKTKDPII------RE-KTYNALNNL-SVNAENQG
KIKTYISQVCDDTMVCRLDSAVQMAGLRLLTNMTVTNHYQHLLSYSFPDF-FALLFLGNH
F-TK-IQTMKLIINFTENPAMTRELVSCK---VPSELISLFNKEWDR----------EIL
LNILTLFENINDNIKNEGLASS---------RKEFSR--SSLFF-LFKESGVCVKKIKAL
A-NHNDLVVKVKVLKVLTKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
---------------------------------MGYARKVGWVTAG----------LVIG
ASACYCIYRLT--RGRKYNKEK-MA----EGGSGDVD--DAG----------------DC
---------------------------------------------------------SGA
--RYNDWSDDD-------------------------------------------------
DDG----------------N--------D-------------------------------
------------------------------------------------------------
-SKSIVWYPPWAR-----------------------------------------------
------------------------------------IG----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------T--------------------------------
-----------EAGTRARARA---------------------------------------
------------------------------------------------------------
-------------RARAT---------------------------RA----RRAVQKRAS
PNSDD--------TILSPQELQKVLCLVEMSEKPYILEAALIALGNNAAYAFNR------
----------DIIRDLGGLPIVAKILNTRDPIV------KE-KALIVLNNL-SVNAENQR
RLKIYMNQVCDDTITSRLNSSVQLAGLRLLTNMTVTNEYQHMLANSISDF-FRLFSAGNE
E-TK-LQVLKLLLNLAENPAMTRELLRAQ---VPLSLGSLFNKKENK----------EVI
LKLLVVFENLSDNFRWEENEPT---------QNQFGE--GSLFF-FLKEFQVCADKVLGI
E-SHHDFLVKVKVGKFMAKLAENMFPKIQE------------------------------
-------------------------------------------

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---------------------------------MSRVRDAGCVAAG----------IVIG
AGAWYCVYKYT--RGRDQ-KKRRPT----KPKNRA--VAGTAARDRAGLRAGFTIDLGPG
FSPPTTVCAGAEDK-VQDETSAFDMAGAKAFVPAS------SSTEAKNETESLAQETER-
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
-------------------AG--------TGT------------KKSKAEVDELGMGFRP
GD---------GAAAAAAASAN------------GGHAFLAEVPDS-----EDGESGWTD
TESDSDSEPETQRRGRG----------------------------KK----TVAMQKRPF
PYEID--------EILGVRDLRKVLALLQKSDDPFIQQXXXXXXXXXXXXXXXX------
----------XTIRKLGGLPIIANMINKTDPHI------KE-KALMAMNNL-SENYENQG
RLQIYMNKVMDDIMASNLNSAVQVVGLKFLTNMTIXXDYQHLLVNSIANF-FRLLSQGGG
K-IK-VEILKILSNFAENPDMLKTLLSTQ---VPSSFSSLYNSYVES----------EIL
INALTLFEIIYDNLRAEVYN----------------------------------------
------------------------------------------------------------
-------------------------------------------

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-----------------------------------------------------LTIKQKA
-AAW----SRA--RNCVLVPVE------------GG--QGS-LPP---------EGNWTL
VETLIET--------PLGIRPLTKIPPYNGPYFQTLAE------IKKQVRYREKYGPNPK
ACRCKS-----RVFSLEPKEFDKLVALLKLTKDPFIHQIATMIMGISPAYPFTQ------
----------DIIHDVGITVMIENLVNNPNVKE------HR-RASNMVDDN-SESSAGPN
TGESYINQVCKDITSYPLNSPLQLAGLKLLVQLSVKFEDHHTIVSYIPDF-LTLLNKGSV
K-TK-FYVLKVFSRLSKNQANTRELISAK---VLSSLVAPFNKNESK----------ANI
LNIIEIFENINFQFKKKVKLFTK--------EE-FTK--SELI-SIFQEAKEFGQKLQDL
A-EHSDPEVRDKVIRLILKL----------------------------------------
-------------------------------------------

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-------------------------------------------------------MGFRP
GD---------GAAAAAAASAN------------GGQAFLAEIPES-----EEGESGWTD
TESDSDSEPEVQHRGKG----------------------------KR----TIPMHKRPF
PYEID--------EILGVRDLRKVLALLQKSDDPFIQQVALLTLSNNANYSCNQ------
----------ETIRKLGGLPIIANMINKTDPHI------KE-KALMAMNNL-SENYENQG
RLQVYMNKVMDDIMASNLNSAVQVVGLKFLTNMTITNDYQHLLVNSIANF-FRLLSQGGG
K-IK-VEILKILSNFAENPDMLKKLLGTQ---VPSSFSSLYNSYVES----------EIL
INALTLFEIIFDNLRAEVFN-----------YREFNK--GSLFY-LCTTSGVCVKKIRAL
A-NHHDLLVKVKVIKLVNKF----------------------------------------
-------------------------------------------

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---------------------------------MSRVRDAGCVAAG----------IVIG
AGAWYCVYKYT--RGRDQ-TKKRMA----KPKNRA--VAGTGARARAG------------
-----------------------------------------------------AQEADGA
--GVGPKA-ESIVGAAMASTIAPPPGVTEAL------------GAAEAPAMTGAPKVAEA
PRE----------------V--------ETSR----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------TSAAKKATPGAHTGAIPKATS--ATGA---VPKGGA-------
-----------KGVTRSRNGG-K----GKGK-------------K-N-------------
------------------------------------------------------------
----SDSEPETQRRGRG----------------------------RR----PVAMQKRPF
PYEID--------EILGVRDLRKVLALLQKSDDPFIQQVALLTLSNNANYSCNQ------
----------ETIRKLGGLPIIANMINKTDPHI------KE-KALMAMNNL-SENYENQG
RLQVYMNKVMDDIMASNLNSAVQVVGLKFLTNMTITNDYQHLLVNSIANF-FRLLSQGGG
K-IK-VEILKILSNFAENPDMLKKLLSTQ---VPASFSSLYNSYVES----------EIL
INALTLFEIIYDNLRAEVFN-----------YREFNK--GSLFY-LCTTSGVCVKKIRAL
A-NHHDLLVKVKVIKLVNKF----------------------------------------
-------------------------------------------

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-----------------------MINSSAREKAREEIGDGLKAE--------ISGP----
------DNAGVRDEAKAMAVV-----EAEPKSELV----TQVKFGDGTMAMTQTMTYTEP
--VTGTKEVNKM------------------------------------------------
------------------------------------------------------------
-----------ENMTDNRVMDQTKTKVLL-ELGIVPQTKSEASSMSRL--SAITKSTVRV
V-----------------------------------------------------------
-------SGSEASFRSCSKAD-----DRANIVSRYET-----------------------
--------KEETSIKSM----------AR-------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------NKVGIGI-----------------------------KSTDEEEENICSWFW
IGEE------------------------PK---------EISLQI---------------
-----YKSPPK---------------------I-QERP----------------------
------------------------------------------------------------
----------------------KPTHK------------------------SKLTIKQKA
-TAW----SRA--RYIVLVPIE------------GE--EQP-LPP---------EGNWTL
VTTLIET--------PLGIRPLTKIPPYNGLYFQTLAE------IKTQIRQREKYGPNPR
AGLCKS-----HCFSLEPKEFDKLVALL------------------NPSYPFTQ------
----------DVIHDVGIIDMIENLINNPNDHE------DS-GDFDVVDSS-SESSEEGK
MGESYIYTICKNIMYCSLNSPVQLAGIKLLVHLSVKFKNHHLIVSYIPDF-LTLLNNGNV
K-TK-FCILKVFLCLSKNQANVRELISAE---VLSSLVALFDKSESK----------GLI
LSILEIFENINFQFKKRAKLFTK--------EH-FTK--SELI-SIFQEAKGVGQKLHSL
A-EHSDYEVRDKVIQLRLKL----------------------------------------
-------------------------------------------

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---------------------------------MGGARAAGWVAAG----------LLLG
AGAGFCLYRLA--RGRRR-G----------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
-------------------GHG------------LRSSR---------------------
--------------SA-------------------------------------E---DLT
NGSYD--------DILNSQQLQKLLYLLESTEDPIITERALVTLGNSAAFSTNQ------
----------AIIRELGGIPIVGNKINSPNQSI------KE-KALNALNNL-SVNVENQM
KIKVYIGQVCEDVLSGPLDSAVQLAGLRLLTNMTVTNEHQHMLNSFLADL-FHVLLTGSG
T-TK-VQVLKLLVNLSENPAMTEGLLSVQ---VDSSFLSLFDGHVPQ----------EIL
LRVLTLFQNINNCLRVGGHAAV---------QPPFPE--GSLFSLLYGE--ECVQKMRAL
V-CHDDMDVREKVATIIPNF----------------------------------------
-------------------------------------------

------------------------------------------------------------
--------------------------------------------MGRVQEVGWATAGLVI
WAGTCYCIYRLTRGSVQSVRRRTRNGSRV-KTETMVE----VQNQTVATSEAMAGTEFET
RAK--TEAETGERGGPMAEVDTKVTVLARPNVNSQ----AEAMLEEETETQCE-------
TNSVVETMFMAEAVTLTEAK----AKEVTLKEAVTQTDAEAGGAGKREAVTQTK-AKAWA
VADRAEVKKEAVTQTKTEAPVLAEKETEINRVTVTQSEVLAVTKE----VVKIGTMNNTG
IVAEANITALEDTVSVTRTQSEARLGATVDAKENPNGMSMIVAGVDMKSYAQPQAVALIQ
TDDMLGAGVEDSGNLE---------------------------PMPNAEPGVDTKASAQP
HIVASVLAEAMPEARNDAWDNMNVICKAEAEADMRICVIQPQNVAMTQAEAMSGAR-VDG
TENSNAISKAVTGADIGTAIQAQDVSSAQDEAMPDARVKGRGNSTVMAKAGTRENTQTNL
QSEALPDTGDKTRSNPADMANTEANADILSYT-DPQPVASCQGDALPDGRIKAKDNANTM
SKESAQA--------TAQSQCEALPNSKGKARGKAKAKCKAGAGTDMKTCTQPQAGTKTQ
AETLSDSKADDKSDPNAISRTGAKADQKVCGQPQAVANCQNEALFGTKNKVKGNPNAVPK
AEAETATTGSAQT-----------------------------------------------
------------------------------------------------------------
------------PAMASSQGETMPGAKNKVKGNRNAVPKAGAGPDT--------------
--------------------------MGSAQSQTVANSHSEVLPGAKNKVKSNPNAVPKA
EAGVGACSQSV-------------------------------------------------
------------------------------------------------------------
--------------------------AISQGIALTGTKTKVKGNSAAMSKPEYGA-----
------------------------------------------------------------
-------------------------------------------------------GITAS
PHAKAGANSQGETLPGAKNKVKGNPNAVPKAE-----AGAGTTNS----AVASSQAEALL
GARNKVKGNSSSVPKAEAGAGTILA-----------------------------------
------------VASSQAETLLGARHKVRGNSNAVPKAEAGAGAKGSAQSQSVVSSQNQA
LLGARNKA----------------------------------------------------
----------GAI-PTETHGGAGAQAYERAQPNIHDYYWNGIGVEDWIAAERWIKFRFQT
MDGDWENSVSWTDEENAASVGTWGGA-NDK--AGIVSSWAVAC----DETSIKSWTGARA
ENEVALGSWVGAG-DQASGGLWAGAQASEGVWAGD------------KASGGSWTGTENQ
ISAGSWVVSGNQAIAGPWAVSQVSDGTWPTVQASGVSWVVDQATG-AWTV----------
--TGAVSWTGA--------------------------GNIVSIGYWTGAVDQTNA-VSWT
GTP-----------AEQSGAEAKPRFEDQASEKASWAGASG----------QDQSNGRSW
ADTADQPSGGSRLGTIDPSSSVSWAGTGDQAGGGPAQTS----DEGPWAG----------
------------------------------------------------AKSAPEDQSTGR
SWADSGDQVSGGFLVGALDQSNGESQAGS----GELAAGGVNPVFEDQATGGGCWA-GSG
DQSGGESKQGPRDPSNGESWPGTGSQASG------------WY-------------CTYT
G---GQAIGGGSWGGAGGLIVGGSKPVHMSQSSSGSWLGTGTQVSGGSWTN---------
--------DPVGGGFWFGAGDQTSGGARPAVSED-QSSGGVSWGGAGGHVI---------
------------------------------------GGSRACPTVQASGGSWTGIG---S
QVSGGSCVGPG--DQ-AGGCSKPGFEDQ-ACRGSSWVGTGDQASGESWPGSRSGNE----
---ASGG-----N--Q--------------------------------------------
----------------------------ASGGSWVRSEDQASGRFLVSAEVEANEGFWFG
PGSEAFIGSWW-TGEETIVSSGLGDENKTRSEEA--ASLSTCIEAEAEVETVAEGEAKVE
GGAEAGAKAGA--------GAETEAGAETEAGAEAGAGAGTEIE--AGAETGTGTEIETG
AGAETEAGGGAGVETE--AVA-----EAEAETG--------AEAGPETEAKDGTGVETGA
EVGFWSWDGDAATKGSRLVTE--------------------AETGVEVGAEAGA------
ESGAEATAGFWFWDGDAAAKESRLGTEVEAGAGVEAGPGAG--AGVEAGPGARAEPGVES
RVGFWPWDGDAA-TKGSSIGAEVETETGFGAEA------AAANERSRIGAGAEAEAEVGA
GAGAEDRIGFWSWDGEEATKRSRLGAEAETG--AGDEAGAEARM----EFWSWDGDAVTK
RSNLGTETGAEAAVGTTAGAG-----AEARMEFWSWDGDAVT----KGSRVGDEA--E-T
GTEDEAGVGAGAKAGTE----------AGAEAG-MGFWAWDGDVATKGSRIETEVGAG--
------------------------A--------------------------------G--
AGVEVG-------------------------------AQAGPESGAESTMGFWFWNGDAT
TKESRLGVEAEAGAGV-----------------------------GAEAGAEATMGFWSW
NGDT------------------------TTKGSRLGAEEGTGLR----------------
----TWTFSTDIDDD--D-DDDELSRGSSP-GI-EEIS----------------------
-LKSLFWAENENNNDLSSK--------SEKD--GNFESGEEDKA-NAKVKFDA-------
-ADGVDIRSWLCTGNENRSED-NSTSKAKAKKGAE-S----------RGTYPSM-VPGAG
MGLW----DGAIICSETK--FL------------RQ----SGFLGED----E-----FR-
IQ-I-----------------------------------VT------------GDKIRPW
TCRCKE------EANIDPQDLEKLICMIEMTEDPSVHEIATNALYNSADYPYPR------
----------EIVRNVGGISVIESLLNNPYPSV------RQ-KALNALNNI-SVAAENHR
TVKTYLNQVCEDTVTYPLNSNVQVAGLRLIRHLTITSEYQHMVTNYISEF-LRLLAAGSG
E-TK-DHVLGMLVNFSKNPSMTKDLLIAN---APTALINIFSKKETK----------ENI
LNALLLFENINRHFKKRAKAFPQ--------DK-FSK--NSLY-FLFQRPKACAKKLRAL
AAECSDPEVKERVEVLINKL----------------------------------------
-------------------------------------------

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------------------------------------------------------------
-----------------------MVDSGTEARARGKAEAGLQDG--------ISGP----
------ATARVNGKTQAKAVA-----EAELKTESV----TQAKAGDGAMTRMHKVTYREA
--MAVTREVSKM------------------------------------------------
------------------------------------------------------------
-----------EDTTKSRVMVETKTKPLA-ERSIVPQTKSKAMPMSGV--SAVTKSEVKV
V-----------------------------------------------------------
-------AVIEANIRSYAKSH-----DKANTGSRPDR-----------------------
--------REEA------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------SIGM-----------------------------KSSDEDEENICSWFW
TGEE------------------------SSVGSWFWPEEETSLQV---------------
-----YKPLPK---------------------I-QEKP----------------------
------------------------------------------------------------
----------------------KPAHK------------------------PTLTIKQKA
-IAW----SRA--RYIVLVPIE------------GG--EQS-LPP---------EGNWTL
VETLIET--------PLGIRPLTKIPPYHGPYYQTLTE------IKKEIRQREKYGPNPK
ACHCKS-----RGFSLEPKEFDKLVALLKLTKDPFIHEIATMIMGISPAYPFTQ------
----------DIIHDVGITVMIENLVNNANVKE------HP-RALSIVDDS-SESSEEPK
SGESYIHQVCKDIVSCPLNSPVQLAGLKLLGHLSVKFDDHYVITSYIPDF-LTLLNKGSV
K-TK-FYVLKVFSCLSKNCANTRELISAK---VLSSLVAPFNKHESK----------ANI
LNIIEIFENINFQFKTKVKLFTK--------EK-FTK--SELI-SIFQEAKQFGRKLQDL
A-EHSDPEVRDKVIRLILKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
-------MTGAEVEPVAQAKPEKKPGEEVV--------G-----------GAERENEVPM
VVRPKV--------------------------RNQA--TSGARSKTESKA----------
--------MAGARPKTESQTVAGARPRT----------------------------ESQP
VAGARPKT----------------------------EFQAMAGARPKTE------ARAVG
RARPKT--EARAIPGARPKDEA--------------Q--------------VWAQTEFG-
-----AEAMLQAEGMPQTSVVAWPLVSTES--GSVTKPMALSVDRELVNVDSETFPSSQ-
-VQTGIQPWFGSG-EETS------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---MGSWCYPRAKAR-EEASSESGFWSADETSTMSSFWAGEEASIRSWPREEA---NTRS
RHRAKHQ-----P--NPRSRPRSKQDPFIDS-WSGSE-----------------------
-EESGNPFCLWAGENTNNLF----------------------------------------
---------------------RSRIRDEANMRSKLRAKREDF--FESESE------DEYY
KESWFLPEEEA---------NSR-----FRPRDKEEPNTVLKPR----------------
TQ----KVVNNSDRVKQEPRF-----EEEVIIGSWFWAEKEA------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------SM
EAG------ASAICESEAGAE-----EGAI------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------GGSLFWTEENS
SLGA--------------------------------------------------------
-----------------------------------------------VAREETRPES---
------------------------------------------------------------
------------------------------------------------------------
-EEEAIFGSWFWDRDEACFDL-NPRPVYKASPRFRDAAEEEVNVSSRPKTWEEVTVEFKP
-GPC----HGVGFPSPSPFRIPEEATTSVYTELFEGKPKNVEVTPEG----E--EQESLL
QSDQ--PDSEFPFQYDPSY--------------------RSVREIREHLRAKESAQPESW
SCSCIQ-----CELKIGPAEFEELLLLMDKIRDPFIHEISKIAMGMRTASQFTR------
----------DFIRDSGVVSLIETLLNYPSSRV------RT-SFLENMIHM-APPYPNLN
MIETFVCQVCEETLAHSVGSPEQVLGLRMLRHLTSTTDYHTLVSNYMSGF-LSLLTTGNA
R-TK-FHVLKMLLNLSENPMVAKKLFSAK---ALSIFVGLFNIEETN----------DNI
QIVIKMFQNISNIIKNGTMALID---------DDFSL--EPLI-SAFHEFEKLAEELQVQ
INNQSDPEVGQQS-----------------------------------------------
-------------------------------------------

------------------------------------------------------------
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---------------------------------MGGARAVGWVAAG----------LVLG
AGACYCIYRLV--RGPRR-GQRRGD----RARHRLRP--SR-------------------
------------------------------------------SAE---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------DLT
DGSYD--------E-LNAEQLQKLLYLLETTEDAVIIEKALVTVGNN-------------
---------------------XGNMINNANHSI------KE-KALNALNNL-SVNVENQS
KIKIYMNQVCEDVFSDPLDSAVQLAGLRLLTNMTVTNDYQPMLNSYITDL-FHVLLIGNG
T-TK-VQVLKLLLNLSENSAMTERLLSAQ---VDSSFLALYDSYVAK----------EIL
LRALTLYQNINNCLKVDGRLAC---------QPTFTK--GSLFFLFYGE--ECAQKMRAL
A-NHPDADVKEKAVIMKC------------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
-------MTGAEIEPSAQAKPEKKAGEEVG--------G-----------GAERENEVPL
VVRPKV--------------------------RTQAQVMSGARPKTESKSMPGARPKTES
------QAVAGARPKTESQAMAGARP----------------------------------
------KT----------------------------ESQAMAGARPKAE------AKAVG
GARPKT--EAKAIPGARPKDET--------------Q--------------AWAQTEFG-
-----AEAMSQTESLAQTNAVAWPLVSTDS--GSVAKPLALSVDRELVNVDTETFPGSQ-
-VQTGIQPWFGTG-EEAN------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---MGSWCYPRPRAR-EETSNESGFWSADETSTMSSYWAGEEASIRSWPREEA---NTRS
RHRAKHQ-----P--NPRSKPRSKQDPYIDS-WSGSE-----------------------
-EESGNPFCLWAGENTNNLF----------------------------------------
---------------------RPRVKDEANMRSKLRTKREDF--FESESE------DEYY
KESWFLPGEEA---------NSR-----FRTRDKEEPNAILKPR----------------
AQ----KDVNNSGRVKQEPRC-----EEEVIIGSWFWAEKEA------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------GM
EAG------ASAICESRPGVE-----EGAI------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------GGSLFWTEEKS
SLGA--------------------------------------------------------
-----------------------------------------------VAREEARPES---
------------------------------------------------------------
------------------------------------------------------------
-EEEAIFGSWFWDRDEACFDL-NPSPVYKANSRFRHSAEEELKTSSRPQTWEEVTVEFKP
-GPC----HGVGFPSPSSFRIPEEA-ASVFSEMFEGKPKHAEFTSEG----E--EQESLL
QPDQ--TEPEFPFQYDPSY--------------------RSVREIREHLKARESAEPESW
SCSCIQ-----CELKIGTGEFEELLLLMDKIRDPFIHEISKIAMGMRSASQFTR------
----------DFIRDSGVVSLIETLLNYPSSRV------RT-SFLENMIHM-APPYPNLN
MIETFICQVCEETLAHNVGSPEQLLGLRMLRHLTITTDYHTLVANYMSGF-LSLLTTGNA
R-TK-FHILKMLLNLSENPIVAKKLFSAK---ALSIFVGLFNIEETN----------DNI
QIVIKMFQNISNIIKNGTMSLID---------EDFNL--EPLI-SAFHEFEKLAKELQVQ
IDNQNDPEVGQQS-----------------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------MTGAEIEPGVASKPETKAGEEVV--------G-----------GAERENEVPL
VVRPKV--------------------------RIQAQIMNGARPKTKTKVMPRARPKT--
------------------------------------------------------------
------------------------------------------------K------ASTGG
GAHSKS--KSKGILGSESKGDA--------------Q--------------VWAQAECG-
-----AMAMLKTEGESPT-------SSAFS--RSVAKTKCLSVDRELLNMDTESFPRRKD
NSQAGFQPSFRSE-GEDG------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---IESWYCPKPLSK-QETS------------LCSLFWNRDEVSSKFRPRNRIKA-STRS
RHMARKE-----V--NILCKPKTKKELCTVS-SSGSE-----------------------
-DESVKIPCFWAKDQTYSWS--RPREEA-NNWSRFTSKTQVCV------------ESSFG
SDREDHMKSWFWSREGIKSRSKPRARKEANTRARQRAKQEACMDFISGCM------DVRK
NEPWFLPGEKA---------GNF-----LWPKTKKEARARAMAK----------------
EE----AKAKTRAKAKREVKS-----EEEVLIGTWLWATEESSMVDGANIMSISQMEGES
LVGSWFWTEEEDSLGTGASKS--IPRAKVEPSCDSYLGAV-KNTSVASGTAGASETMLAA
-DE-EVIVSSWFWVGEE-AN---------------------------------PEPEEET
IFGSWFWDIDETS-VESGTAVSCE-------------------------------SRQK-
-SEEEAAVGPWFWTGEEGSVVAAVGEE----------AKSGSEEDTIFGSWFWSENQPPV
DSR------DEASCDTVPVGEEE--EEEPIIGSLFWAGVDTWVEAEVNSMSNLEDEEE-A
IVSPWFGVKEEVSMKYGAGARCKFMTGAEEK-DRSYFWEKGKPFMYPADGGSWNSKPKEE
-----EDTVDSCFWSKNYSRPGAIVG------------------------SSLCAAEGGS
IDDETGEEARLPTEGENVIKPLFWKDD-EAIQETTSREDPRPAAEEEYIVGSWFLAGEEY
GLEAVPKVREENILTTEEE-AVLGSWFWEEP-VR-REAGFCNKSSVTSEEEEVIVGSWFW
EEGARTGTVIEASSESKPGTEEE----EIIIGSWFWDEE-ASIETGSHAVDKTRS-ETEE
NVFGSWFWAAKE-----GDGESGVCHVSSPQDD-EEMI----------------------
-VESWLWSGEEAIKETGT--VATCESENEEGAVAGSWFGAQNEENDGTGSGTNCESRTFA
DEDEAIVGSWFWAGDEPHFES-NPSPVFRAICKSRCSVEQEPDPSRRPQSWDEVTVQFKP
-GPW----GRVGFPSTSTFNFPKEA-VFLFSEMFGGKPKLLELSPER----E--EQESLL
QPDQ--PDPEFQFRYDPSY--------------------RSVQEIREHLRDKESTGPENW
SCSCIQ-----CELRIDSEEFEELLLLMDRIRDPFIHEISKIAMGMRSASQFTR------
----------DFIRDSGVVSLIQALLNYPSSRV------RT-HFLENMIRM-TPPYPNLN
MIQTYVCQVCEETLAYGLDTPEQLCGIRMITHLTSTTDYHTLIANYMSEL-LSLLATGNT
Q-TR-FHVLKILLNFSENLVMTKELLSAE---AMSEFMGLVSRNETN----------DNV
QIILAIFENIGNNIKKEAV-FT---------DDDFDL--EPLI-STFHEVEKFIKELQSK
PDDPNDPEADQEN-----------------------------------------------
-------------------------------------------

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-------MTGAEIEPSAQAKPEKKAGEEV--------IA-----------GAERENDVPL
VVRPKV--------------------------RTQ--ATTGARPKTETKSVPVARPKTEA
----------------------------------------------------------QA
MGGARPKT----------------------------EAQGIAGARPKTD------ARAVG
GARSKT--DAKAIPGARPKDEA--------------Q--------------VWAQSEFG-
-----TEAVSQAEGVSQTNAIAWPLATAES--GSVTKSKGLSMDRELVNVDAETFPGTQ-
-GQKGIQPWFGPG-EETN------------------------------------------
------------------------------------------------------------
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---MGSWCYSRPRAR-EEASNESGFWSADETSTASSFWAGEETSVRSWPREES---NTRS
RHRAKHQ-----T--NPRSRPRSKQEACVDS-WSGSE-----------------------
-DEAGNPFSFWAGENTNNLF----------------------------------------
---------------------RPRVREEANIRSKLRTNREDC--FESESE------DEFY
KQSWVLPGEEA---------NSR-----FRCRDKEDPNTSLKPR----------------
AQ----KDV-DSDRVKQEPRF-----EEEVIIGSWFWAEKEA------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------SL
EGG------ASAICESEPGTE-----EGAI------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------GGSAYWAEEKS
SLGA--------------------------------------------------------
-----------------------------------------------VAREEAKPES---
------------------------------------------------------------
------------------------------------------------------------
-EEEAIFGSWFWDRDEACFDL-NPCPVYKVTDRFRDAA-EELNASSRPQTWDEVTVEFKP
-GLF----HGVGFRSTSPFRIPQEAS-----EMLEAKPKNLELSPEG----E--EQESLL
QPDQ--PSPEFTFQYDPSY--------------------RSVQEIREHLRARESAESESW
SCSCIQ-----CELKIGSEEFEELLLLMDKIRDPFIHEISKIAMGMRSASQFTR------
----------DFIRDSGVVSLIETLLNYPSSRV------RT-SFLENMIHM-APPYPNLN
MIETFICQVCEETLAHSVDSLEQLTGIRMLRHLTMTIDYHTLIANYMSGF-LSLLTTANA
R-TK-FHVLKMLLNLSENPAVAKKLFSAK---ALSIFVGLFNIEETN----------DNI
QIVIKMFQNISNIIKSGKMSLID---------DDFSL--EPLI-SAFREFEELAKQLQAQ
IDNQNDPEVGQQS-----------------------------------------------
-------------------------------------------

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-----------------------------------------------------XX-----
-XXXXXXXXX--------------------------------------------XXXXX-
XXXXXXX---X-XXXXXXXXX-XX-----XXLGLRPSQSAGALEEG----------TP--
-ERQLC--GRS--ARPRA-GP---------------------------------------
------------------------------------------------------------
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------------------WESQ------------WSKTS---------------------
--------------QP-------------------------------------E---DLT
DGSYD--------DVLNAEQLQKLLYLLESTEDPIIIEKALITLGNNAAFSVNQ------
----------AIIRELGGIPIVGNKINHSNLSI------KE-KALNALNNL-SVNVENQI
KIKIYINQVCEDVFSDPLNSAVQLAGLRLLTNMTVTNDHQHMLHSYITDL-FRVLLTGNG
N-TK-VQVLKLLLNLSENPAMTEGLLRAQ---VDASFLSLYDSHVAK----------EIL
LRVLTLFQNINNCLKIEGHLAV---------QPTFTE--GSLFFLLYGE--ECAQKLRAL
V-HHDDAEVKEKVVTIMPKI----------------------------------------
-------------------------------------------

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---------------------------------MGRTREAGCVAAG----------VVIG
AGACYCVYRLT--WGRDE-SEKIWD----GDDEEDEE--EEESI----------------
-------------------------DIVESGVKTG------KGAKANAGMGTGARLQGEA
-----------------------------KV------------KAEVGMELQSGSDIKAA
AQV----------------G--------AQSGGGLE---AKA------------------
-----------------KALFNT-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------L----------------------------------
----------------KEQASAKAGRGARLSTIS--------------------------
---------------------------------------------GNRTLAPSLPCPGGR
GG---------GCHPTRSSRV----------------------------------GSRAS
GKTKGRTRGKSTRTPA-T---------------------------AW----PVRRGKFNF
PYKID--------DILGAPDLQKVLNILERSNDPFIQEIALVTLGNNAAYSFNQ------
----------NAIRELGGLPIIAKLIKTKDPII------RE-KAYNALNNL-SVNAENQG
KIKTYISQVCDDTMICRLDSAVQMAGLRLLTNMTVTNHYQHLLSYSFPDF-FALLFLGNY
F-TK-IQIMKLIINFTENPAMTRELVSCK---VPSELISLFNKEWDR----------EIL
LNILTLFENINDNIKNEGLASS---------KKEFSR--SSLFF-LFKESGVCVKKIKAL
A-NHNDLVVKVKVLKVLTKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
--------------------------------------------MGRIQEVGWVTAGLVI
CAGTCYYIYKVTKGRDQSVRRLARNGSRV-KMETVVG----VQNQTLAINEAT----IET
RPKTKTGA----EGGPGAEVDTKVTARARPKANSR----AKAMAEEEAKIQSE-------
AKVVSGTLDMTEAVTLNEAETEAEAREVALKEAVTQTDGEAGRLVKKEALTQTK-AKSWA
VDAKDEAKKEAMTQTKAEARILAEK--EINRVMVTQSETLAVTRE----VAKMEAMNKTG
IVAETKARALEETVSVAKTQSEARPGATVDARGNSNGMSREVAGVDMKSYAQSQAVTKIR
GDDMPGAGVEDKGNCK---------------------------TMSGA----DMMA--SA
QIVAKSQAEATPGARVDAWGNVNAMCEVGAGADMRACI-QP----QKQAEVISSAK-VDG
RGNTNVMLKATTGADTWAAAHPQAVASAQAEAIPDAKVKGRSNPNAMAKAGARANSRVNS
QAEALPDAKDKSRGNPNIMAKAEAGTDMLSCT-HPQPVANVQADSLPDGQIKAKGNADTM
SKEGAGTDIRAQPQVMAQSQGEALPNTKGKAKGKAKAKCKAGIGTDMKTCVQPQAGAKTQ
AEASPDCKVDGKGDLNAVSRAGAKADQKACGPPQVVTSSQGEALPGSKNRVKGNLKAVPT
AETGAGTTGSAQV-----------------------------------------VASSQG
EALPGTKNKVKCNSNAVSKAG---------------------------------------
-AGTDTTDFAQPQVMASSQGEALPATKNKVKCNSNAVSKAGAGTDT--------------
--------------------------TGSAQPQSVAYSQGEALPGAKNKVKGNRNAVPKV
GAGA--------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------DTTGSAQPQSVSNSQSEALLGAKNK
VK----------------------------------------GDLNAVSKAEAGAGTMGS
AQPQAVATSQGEALLGAKNKVKGNPNAMSKAE-----TGMSAVGSAQTQAMAKSQNEALL
GARNKVRGNSNAMSKAEVGTGTMGSAQPQVVAISQGEALPGAKNKVRGS--LNAVSKAEA
GANTMSSAQPQAVTNSQSENLLGARSKVRGNLSAVPKAGSGAGKRHSSRSQVVASSQ---
-------------------------------------GETLPGARDKAMTSSEAEATAEH
VVYAKPD--AETVPTSESEVG-------KTQPNVHDYYWNGIGVEDWIAAERWIKFRFQA
MDGDWENSVSWADDENVAGIGSWSGA-NDK--ADVAGSWAVAC----DEASVKSWAGARA
ENEVSIGSWAGAG-NQASGGIWVGGQSSEGSWAGDKASGSTWAVAEGRAIGVSWTGAENQ
ACGGAWAVSGNQAIGEVWAGGQASDGSWPGG-----------AIGGSWTG--------AE
NQVSGASWAGT-------------------------------------------------
------NGLSWAGTGDQSGNGSKPQFEGQ-------------ASGGCRVGPEDQSSGGSW
ANIADQASGGSRLGPVDQSGGGSWAEAGDA------------------------------
------AMGGAWTETGDQSGGGSKPRFENQASEGG-SWVGAVGQAGGGSKLGPEDQSSGR
SWANSGDQINGGFLVAAVDQATGGSWAGAGAGAGDPASGGAKPVFEDQASGGGSWA-NAG
DQTGGGSRLGPREQSSGVSWAGTGDQASG------------WF-------------CIYT
GNQ-THGGGGGSWAGAGG------------------------------------------
--------QTIGGGFWISAGDQASGASRPGPEDQS--SGGCSWGVAGGQLI---------
------------------------------------AGSRPGPADQSSGGSWTGTG---N
QASGMSWVGPG--DQ-AGGCSKPEFEGQ-ACGGGSWAGSGDQGSGEPWVVSRPENE----
---ASGE-----------------------------------------------------
--------------------------------SRLEPEGQASGRFQVSFEVEANEGFWFG
PGAEACIGTWCWTGEEAIILPRLDIKEK-AIESKSGAGEEAGVSSSSEAE------NKAV
IGCWVRPQEAA--------FMGFCVGAEAGAEAGAEAGAETRAE--AGAEAGAETG----
-----------------------------------------------------------A
EAGAETGAEAGAEAGTEA----------------------------------GA------
EAG---------------------------------------------------------
-------------------------------------------------------AEAGA
ETGAEA--GA--EAGAEAG--AEAGAEAGAEAG------AERGAE--AGAERGAEAGAER
GAEATAEAEVEEGAEAWAVAG-----AEG------------G----AV------------
-------------AGAE----------GGAEG----------------------------
------------------------------------------------------------
----------------------------------------------GAVAGAEGGA----
--VAGAEGGAVAGAEG-----------------------------GAVAGAGARRGFWSL
GGDA------------------------TTIGFRLGAREEAGA-----------------
---ASWTLAWD------M-DEDELSRESSP-DI-EEIS----------------------
-LRSLFWAESENSNEFRSK--------SERD--VNFESGAGDNA-SIKDNFEA-------
-ADGVDISSWFCSDYENRSED-KSAPEAKAKMSAE-S----------RGTYPSM-VPGAG
MGLL----DGAMIWSETK--FP------------HQ--IAASFLAEG----D-----VR-
KQ-V-----------------------------------------------------RHW
SCRCKR------EANLDPQDLEKLICMVEMTENPSVHEIANNALYNSADYPYSH------
----------EIVRNMGGISVIESLLSNPHPSV------RQ-KALNALNNI-SVAAENHR
KVKTYLSQVCEDTVTYPLNSNVQLAGLRLIRHLTITSEYQHMVTNYISEF-LRLLTLGSG
E-TK-DHVLGMLLNFSKNPSMTKDLLIAN---APTSLINIFSKKETK----------ENI
LNALSLFENINYHFKRRAKAFCQ--------DQ-FSK--NSLY-FLFQRPKACAKKLRAL
AAECNDPEVKEKVELLISKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
--------------------------------------------MGRVQEVGWVTAGLAI
WAGTCYYLYRLTKGRSQSVTRLARNGSRV-KTETVVG----VQNQTLAMSEALAGVEIET
RPKAKTGAETGEGSEPGAEVETKVTAIERSKANSQ----SKAMVGAEAEIQSE-------
AKSVARTLVMTDAVTLTEVK--VKAREVSMKEAMTQTDAEAGEIVKKEAVTQTK-AKAWA
LVSKTEAKKEAMTQTKAETQTLVEKETEINRVMVTQSEVLAVTKE----VVKIGTMNKTG
IAVESKTRALEETVSVLTTQSDSRFGTTVDSKKNPNGMSRAVAGMDMKSCARSQAVAKIQ
DDDMPGA--EDKRNLK---------------------------TMCKAASKVDTRASPQS
QIVVKGQAEAMPGTRVDMEGNIITMCKAEVGTNVRACIIQPQIVAKKQAEAMSGAR-VDT
----SVIPKAITGNVIRAAAQIHAVACAQTESMPDARVKGRANPNAMVRASAMANMRTNL
QAEALPDNSYKTKSDLSVMAKAGAGIDMLFYT-HAQPVANIQSDE---------------
---GAQV--------MAQ----------------------------------------SQ
GEALPDSRVDGRGDSNAISKAGAKADHGNCGQLQAVVNSQGDALPGTRNKFKGYPNAVSK
AEARTATADSAQPQGLVCSQSETLIAAKSKS-----------------------------
----------RGNRNVVPKA----------------------------------------
ETGAATTSSAQPQTVNSSKGEALPGAKNKVKGNLNAVPKTETGVVI--------------
--------------------------TGSVFPQALASFQGET------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------IIGTRTKVKGNPSAMSKPEAGAGTK--
--------------------------------------DSSQSQTVASSQDETM------
------------------------------------------VNCNVP-KAEVGAGAVGS
SQSQTVACSQGEALLGARNKVRSSPSAVPKAK-----AEAGTVSSSQPQALTISQNEALL
NARNKVRGNSNAMPKVGSQKATKVSAQPQVVASSQ-------------------------
------------------------------------------------------------
-------------------------------------DEVLLGIMDKAMSRSEAEATAED
KVYAKPE--AGAMPTSESEGEPDA------QSNIHGYYWNGIGVEDWIAAERWIKFRLQA
MDGDWENSVSWAD-ENETSIGSWSGT-GDK--PGIVSSWAVAC----DETTVKSWPGARA
ENQSALGSWVGAG-DQASGGLWAA------------I-GGSWVQAENKAIAGSWTGAENQ
VSGASWVVSGNQAIAGPWAVGQVGEVSWPAVQATGLSWVVDQTGRGSWTVAETGSWTVAE
NQASGVSWAGA--------------------------GNIVSIGYWTGAVDQANAGGPWF
GT------------VDQSGSESKPRFEDQAGAS-------AQASGDSSLGPENQSGGRSW
ADTADQASGGSRPGPIDQSNGASWVGPGEQAGGRSTPGSEDQSSGASWAGTRNL------
------AREGSWTGT------------------------GAFGQDGEVSKSGPEDQSSGR
SWADSGDQISGRFLVGVVDQANGESQVRP----GDLAG--------DQATGGRCWTN-AE
DQSVRESRLGPRGQSNIDSWPGTVNQASG------------WF-------------CTYT
G---SQISGGGSWGGTGGQHVGSSRPGPMNQALGGSWAGSGSQISGVSWAVA--GDQAGG
CLKPGFENQAIGAGFWAGAGNQPCGGSRPGSEDQS--VGGGSWTGAGVHVI---------
------------------------------------GASRPDPTDQSSGASWGGTG---N
QVSGGSWVGLA--DK-GVGCFRSGFEDQ-AHGGSTWAGAGDQTGGESWAVSRPGNE----
--------------------------ASGG------------------------------
--------------------------------SRLSSEDQTSGRFLVSAEVETSEGFWFA
PGSEAFIGSWGCTREEVDTVSRPDGKDEASTESTSEPKEKTIISSELGDE------NKAS
TGSWNRSEEVV--------YM----GSCVRAESGSETGAAVEAE--AGAEAEAGA-----
------------------------------------------------------------
------------------------------------------------------------
E-----------------------------------------------------------
------------------------------------------------------------
-----------------------AGAETGTE------------------SGAE-------
-------------------TG-----TEA------------------GTESGAET-----
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------GTEAAA----
--EAGADVGAEAGAEA-----------------------------GADVGAEARIGSWSW
DGQA------------------------TTKGFGLRLKEETTIRS---------------
---WSWALARD------V-DEDELSEPSSP-DI-EEIS----------------------
-LRSLFWAESDNSNEFRSK--------SEKD--FDFKSEIGDEA-SIKDNFEA-------
-ADGVDIRSWFCTGNESRSED-KSTLKSKAKKSAE-S----------RGTYPFM-VPGAG
MSSW----DGAVIWSEMK--FP------------HQ--NESSFPAED----Q-----FR-
-Q-I-----------------------------------RA------------GEKVRPW
PCRCKR------EANLDPRDLEKLICMIELTEDPSVHEIASNALYNSVDYPYSH------
----------EVVRNVGGISVIESLLNNPYPSV------RQ-KALNALNNI-SVAAENHR
QVKTYLSQVCEDTVTYPLNSNVQLAGLRLIRHLTITSEYQHMVTNYISEF-LRLLTVGSG
E-TK-DHVLGMLVNFSKNPSMTKDLLIAN---APTSLINIFSKKEKK----------ENI
LNALSLFENINYHFKRRAKAFTQ--------DK-FSK--NSLY-FLFQRPKACAKKLRAL
AAECSDPEVKERVEILINKL----------------------------------------
-------------------------------------------

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-------MTRAEIEPSAQAKPEKKAGEEV--------IA-----------GAERENDVPL
VVRPKI--------------------------RTQ--ATTGARPKTETKSVPGARPKTDA
------QAMSGA------------RPKT----------------------------EAQV
MGGARPKT----------------------------EAQGMAGARPKTD------ARAVG
GARPKT--DAKAIPGTRPKDEA--------------Q--------------VWAQSEFG-
-----TEAVSQAEGVSQTNAVAWPVATAES--GSVNKSKGLSMDRELVDVDAETFPGTQ-
-GQKGIQPWFGPG-EETN------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---MGSWCYSRPRAR-EEASNESGFWSADETSTVSSFWAGEETSIRSWPREDS---NTRS
RHRAKHQ-----T--NPRSRPRSKQEAYVDS-WSGSE-----------------------
-DEAGNLFSFWAGENTSNLF----------------------------------------
---------------------RPRVREEANIRSKLRTNREDC--FESESE------DEFY
KQSWVLPGEEA---------NGR-----FRCKDKEDPNTALKPR----------------
VQ----KDV-DGDRVKQEPRF-----EEEVIIGSWFWAEKEA------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------SL
EGG------ASAICESKPGTE-----EGAI------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------GGSTYWAEEKS
SLGA--------------------------------------------------------
-----------------------------------------------VAREEAKPES---
------------------------------------------------------------
------------------------------------------------------------
-EEEAIFGSWFWDRDEACFDL-NPCPVYKVSDRFRDAA-EELNASSRPQTWEEVTVEFKP
-GLF----HGVGFRSTSPFRIPEEAS-----EILEAKPKNMELSPEG----E--EQESLL
QPNQ--PDPEFTFQYDPSY--------------------RSVREIREHLKARESAESEGW
SCSCIQ-----CELKIGSEEFEELLLLMDKIRDPFIHEISKIAMGMRSASQFTR------
----------DFIRDSGVVSLIETLLNYPSSRV------RT-SFLENMIHM-APPYPNLN
MIETFICQVCEETLAHSVDSLEQLTGIRMLRHLTMTIDYHTLIANYMSGF-LSLLTTANA
R-TK-FHVLKMLLNLSENPAVAKKLFSAK---ALSIFVGLFNIEETN----------DNI
QIVIKMFQNISNIIKSGKMSLID---------DDFSL--EPLI-SAFREFEELAKQLQAQ
IDNQNDPEVGQQS-----------------------------------------------
-------------------------------------------

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---------------RKQNKEK-MA----EGGSGHVD--DAR----------------DC
---------------------------------------------------------SGA
--RYNDWSDDD-------------------------------------------------
DDS----------------N--------E-------------------------------
------------------------------------------------------------
-SKSIVWYPPWGC-----------------------------------------------
------------------------------------IG----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------T--------------------------------
-----------EAGTRARVRA---------------------------------------
------------------------------------------------------------
-------------RARAT---------------------------RA----CRAVQKWAS
PNSDD--------TVLSPQELQKVLCLVEMSEKPCILEAALIALGNNAAFTFNR------
----------DIICDLGGLPIVAKLLNTRDPIV------KE-KALIILNNL-SVS-----
---VCMNQVCDDTITSHLNSSVQLAGLRLLTNMTVTNEYQHMLANSISDF-FHLFSAGNE
E-TK-LQVLKLLLNLAENPAMTRELLRAQ---VPSSLGSLFNKKEDK----------EVI
LKLLVIFENINDNFKWEENEPT---------QNQFGE--GSLLF-FLKEFK-----VLGI
E-SHHDFLVKVKVGKFMIEIFCSFFCISDSEPI-HHN-----------------------
-------------------------------------------

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---------------------------------------MTGTKN--KTRAQAKTEKK-P
VTQAKAGAEREAPGV------VRPV---------------------AKTRAKAKAKTGSK
-----TDAV---------------------------------------------------
------AEMKAV-------------SKNKVVAEVKEGALSEPETLGRAM-----------
-----GDF----------------------------SSNAGNESTSSTCKNEAGIDAWFW
AGEE------------------------ATINSWFWNGEEAGN-SSST------------
---------KNDKP--------EIGAQVCA----E-------------------------
------------ELEPAAGADCKPKSGAEE------------------------------
EEEENVIGNWFWEGDDTSFDP-NPKPVSRIVKPQP---LYEINEKNRPKDWSEVTIWPNA
PAVTP---AVLGFRSQAPSEASPPS----YIVLASAEENACSLPGA------TACRPSRN
TRSCSQPIPECRFDSDPCI--------------------QTIDEIRRQIRIREVNGIKPF
ACPCKM------ECYMDSEEFEKLVSLLKSTTDPLIHKIARIAMGVHNVHPFAQ------
----------EFINEVGVVTLIESLLSFPSPEM-------RKKTVITL-NP-PSGDERQR
KIELHVKHMCKETVSFPLNSPGQQSGLKILGQLTTDFVHHYIVANYFSEL-FHLLSSGNC
K-TR-NLVLKLLLNMSENPTAARDMINMK---ALAALKLIFNQKEAK----------ANL
VSGVAIFINIKEHIRKGSIVVVD----------HLSY--NTLM-AIFREVKGIIETM---
------------------------------------------------------------
-------------------------------------------

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---------------------------------MGYARKVGWVTAG----------LVIG
AGACYCIYRLT--RGRKQNKEK-MA----EGGSGDVD--DAG----------------DC
---------------------------------------------------------SGA
--RYNDWSDDD-------------------------------------------------
DDS----------------N--------E-------------------------------
------------------------------------------------------------
-SKSIVWYPPWAR-----------------------------------------------
------------------------------------IG----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------T--------------------------------
-----------EAGTRARARA---------------------------------------
------------------------------------------------------------
-------------RARAN---------------------------RA----RRAVQKRAS
PNSDD--------TILSPQELQKVLCLVEMSEKPYILEAALIALGNNAAYAFNR------
----------DIIRDLGGLPIVAKILNTRDPIV------KE-KALIVLNNL-SVNAENQR
RLKIYMNQVCDDTITSRLNSSVQLAGLRLLTNMTVTNEYQHMLANSISDF-FRLFSAGNE
E-TK-LQVLKLLLNLAENPAMTRELLRAH---V---------------------------
-------ENINDNFKWEENEPT---------QNQFGE--GSLFF-FLKEFQVCADKVLGI
E-SHHDFLVKVKVGKFMAKLAEHMFPKSQQ------------------------------
-------------------------------------------

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-----------------------------------------------MGRARE--LGWMA
AGLM----IGAGACYCVYKLTL------------GK--DDDDNS-E------EEEDEWGD
DQELDEEEPKIWFDFTTMARPWNKNRDWTKPGAPDGTEDRPSGGGKANRA--HPMKQRPF
PYDHK--------NTWSPQVFKKISRVLELSKCPCNAGK-LCAEPKDAVSSRGY------
----------DVSRHLACLSITRSTSPTPHPTV------QK-KAWCAPDNL-NGSIENQG
QIKMYTDEVCQETVSPCRDSLLQQDGLNLLISMTVINN---MLAKSFSDLQFPLISKGSG
C-AK-VQVLQLLMGLSEKPALAGELLGAQ---VLFPFMI--NRSGSR----------GIL
LETLAP------------------------------------------------------
------------------------------------------------------------
-------------------------------------------

------------------------------------------------------------
--------------------------------------------MGRVQEVGWATAGLVI
WAGTCYYIYRLTKGRAQSVSRPSRNGSRV-KMETVVG----VQNQTLATSQATAGTEMET
RAEAQTEAETGARGEPMAEVETNITVQAKPKTNSQ----AKAMAKKETETQYE-------
TNSVAGTVVMTEAATLTEAK--GKAKKVTMKEAVTQTDAEAEGLDKKEAVTQTK-AKALA
VAARGDIKKEVMAQTKAEAGTLAEKETEINRVTVTQSEVLAVTKE----VVKIGTMNMTG
IVAETMIRTLDETVSVDRTQSEARPGTTVDAEENPNGMSRVVAGIDMKSCAQSQAVGRIQ
DDGMPGAGVEDKRNFQ---------------------------TMSDVESGIDERASVQP
QIVANTQAEDMPGARVDARDHTNVMCKAGAEADMRTYIIQLQTMDKQKTEATYGVT-VDG
RGNASIICKAMTGADIIA-TQVQAVTSVQVEAIPDARNKGRA--STMAKAGAKANMRTNL
QTEALPDTRDKINSNPNVMANADAKVDMLSCM-QPQPMANFQGDSLSDGRI---------
-------------------------------------KCKAGVGTDMKTCVQTQ------
AEALSDSKVDGRGDSNANSRAGAKADQRAGGQPQVMATCQNDALPGTKNKVKGNTNAVPK
AEAGTATTGSSQT-----------------------------------------------
------------------------------------------------------------
------------HVVANSPCETTPGAKNKVRGSRNAVPKAGAGPDT--------------
--------------------------TGSAQSQTVANSQNEALTGAKNKTKSNHSVVPKA
ETGLTTTGSAY-------------------------------------------------
------------------------------------------------------------
----------------------LQAVAISQGMALTGTKTKAKGNPNAMSKPEA-------
------------------------------------------------------------
-----------------------------------------------------GAGTTGS
VHPKAVGTSQGETLPGTKNKAKGNP----KAE-----AGAGTIDSSQPQALTSPQAETLL
GARNKVRGNSNAVPKTESGAGTMAE----------------------------------A
GASTRGSAQSQALVSSQNEALLGARNKVRSNSNAVPKSGTRTGTRGSTKPQAVVNSQNEA
LFGARDKG----------------------------------------ISSSEVETIAGE
-SYTKS--EAEALPTSEPESRA------GAHPNIHDYYWNGIGVEDWIAAERWIKFRFQA
MDGDWENSVSWAD-ENEASIASWSGA-NDK--AGIVSSWAVAC----DENSIKSWPGARV
ENEVALGSWVSAG-DQASGGLWAGAQASEGAWAGD------------KASGGCWSGAENQ
ASGGSWVVAGNQAIGGPWAVSQVSDGSWPGVQATGVSWVVDQATG-SWTV--------AE
NQASAVSWTGA--------------------------GNIVSIGYWTGAVDQTSA-VS--
----------WAGTADQSGGETKPRFEDQATEKGSWVGAGGQASGESRLGSEDQSSGRSW
ADPTDQASGGSGLGTVDHSSGASWAGTSDQAGGGSTPGSVDQSNGGTWASTTNL------
------VGGGSWTGSGDQSDGRSKPGFENQTNDER-SWTGAIGQAGGGSKLVPEDQSTGR
SWADSGAQISGGFLVGTVDQANGKSQAGS------------RDLVADQTSGGGCWA-GSG
GQSGGESRLGTRDQSNGDPWLGTGDQASG------------WF-------------CAYT
G---SQTNGGGSWGGASGQDVRGSKTVPINQSSGISWVGTESQVSGGSWTSD----HVSG
CSKSVFEDQTIVGGFWASAGNQTSGVSRPLPEDQS--SGVVSWSGPGGHAI---------
------------------------------------GGSTPCPIDQSSGVSWAGIG---S
QVSGGAWVGAG--DQ-ASGCSKHLFEDQ-ACGGGSWASAGDQTSGESWAASRPGNE----
---ANGG-----S--R-----------------LGPEDQT--------------------
-----------------------------SGSSWARSEDQTSGRFLVSAEVEANEGFWFG
PGSEAFIGSWCWTGEGATILPMSNVKNDASIGSASGTTEDTIISSRLGDE------NKAS
IGSWIRSEEVV--------YIGTCVGAEAEAEAGAGTRAGAETEAKVGAETEVGTD----
----------TGAEAR--------------------------------------------
-----------AEAGARA----------------------------EDGAEARA------
EAGA--------------------------------------------------------
-------------------------------EVV-----------------ADTAAEAGA
ETGAEA--------------RAETGAEPG-------------------------------
--------------------------AEA--------------------EVEA----E-A
VARAEAGAEAGAEAGAE----------AGAE-----------------------------
------------------------------------------------------------
------------------------------------------------------------
-VEAGAEAGAEAGAVA-----------------------------GAMAGAETRLGAWFW
GRSV------------------------TTNGSRLGLEEEAGI-----------------
---GSWTLSTD------V-DDDELSRTSSP-DI-EEIS----------------------
-LRSLFWAESENSNEP--K--------SEKD--SNFESGNGDKG-SIKDKFDA-------
-ADGFDIRSWFCTGNENKSED-KTTAEAKTKKSPE-S----------KGTYPSM-VPGAG
MGLL----DGAIMCSETK--LL------------HQ--NEACFLAED----D-----FR-
K--V-----------------------------------KA------------GEKVRPW
FCRCKR------EANMDPRDLEKLICMIEMTEDPSVHEIANNALYNSADYPYPH------
----------EVVRNVGGISVIEGLLSNPYPSV------RQ-KALNALNNI-SVAAENHR
KVKTYLNQVCEDTVTYPLNSNVQLAGLRLIRHLTITSEYQHMVTNYISEF-LRLLTVGSG
E-TK-DHVLGMLVNFSKNPSMTKDLLIAN---APTALINIFSKKEKK----------ENI
LNALSLFENINYHFKKRSKAFPQ--------DT-FSK--NSLY-FLFQRPKACAKKLRAL
AAECSDPEVKERVEILINKL----------------------------------------
-------------------------------------------

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-------MTDVEIEPSAQAKPEKKAGKEVA--------V-----------GAEVDCEIPL
MVRPKV--------------------------RTQAQGTTRARPKTKTNVMAIVGPKI--
------------------------------------------------------------
------------------------------------------------E------ASAVG
RSHTKS--KAKTIAGSQFKFRG--------------T-----------------------
-----------------AHSNASPVVNTNS--GLVAKTKCLSTDRELVNRDTESFHRRKT
HSQTVFQPSLVSDDDKIN------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---MGSWHSHMPTSK-QE---NYNFRWVDKS----SFWNGDEVTTRCHPSNRTKA-RTRT
KHMAKQG-----T--NTMSRFKTNQELYILS-----------------------------
---------------------------------------------------------SSG
SEHEDRMKSRFWAREETKFRSKRRARKEANARARHMARRETCIDFMSEHI------DVIK
KESCFQTEENI---------NTL-----SRPETKKDARTRVIAK----------------
EE----AKTKARARAKQEARS-----EEEVLIGTWLWATEESSMVNRASVQSSPQIEDES
LVESCFWTEEDASMETGPSGNS-KPMAKEESFGGSWLATG-EKASMKTGTESTTESILAA
DDE-EDIIGSWFWTGEE-IN---------------------------------PVTEEET
IFGPWFWVTNGNS-VESVVGVNCE-------------------------------SRPS-
-S-EEEVIGPWLLAGEAIDKETGIREQ----------VRSGIEEETIFGAWFGAENQTHL
DSG------AENSCDIMPGTE----EEEPIIGSCFWAREEACVEADINSKSSLEDEEK-A
IMSSWFGSREEVNMKYGTGASFKFMAGAQETQNRSFSWAE-EPYMYPANGGTWKYRPEEE
-----EDAVSSWFWSGKYTRPEAIVG------------------------SQLSAAEESS
I-DGTGEEAKLLAEEDTMINSCFWKEDEEAIIEATNREKSRSDAEEDDTFGSWLWTGKED
GLKAEAKAGEEDRLVVKEE-SIIGSWFWSKEE----------------------------
--EASLEAVTGKNFEFKSGTQEE----EITVGSSFGAEEEANIETGSQAAEETESETEED
TVFGSWFGA-----------EAGTCFTFKSETIKKVII----------------------
-VKSQFWSEDKVIKETESVASWESKPENEKGTATGSRVGAEDEMNKRTGSTTNCESKTLA
DEDEAIVGSWFWSGDETHFES-NPKPVFRAICASRYSVEQEPDPSQRPQTWEEVAVQFKP
-GPW----GKVGFSSIIPFRFPKEA-ASLFCEMFGGKPTQAELSPEE---------ESKL
EPDQ--PDPEFPFQYDPSY--------------------RSVREIREHLRAKDSAEAENW
SCSCRQ-----CELKIGSEEFEELLLLMDKIRDPFIHEIAKIAMGMRSASQFIR------
----------DFIREAGVVALIETLLNYPSSRV------RT-RFLENIIRM-APPYPNLN
MIETYICQVCEETLTCNLDSPEQLSRIRMIRHLTTTTDYHTLVANYMSGF-LSLLAIGNT
K-TK-FHVLKMLLNLSENIVMTKVLLSDE---TMSEFINLFNREETQ----------DNV
QVVLAIFENIGNNIKK-EE-F----------TDDFNL--APLI-SAFHEVEKFAKEMQSK
RGNQNDP-----------------------------------------------------
-------------------------------------------

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-----------------------MIGSKTKRKAREESGASSKPG--------TNSP----
------ANAKGKAKNQTTKAV-----KAEPKEEWG----NQAEARDEAVARTQPAISTEP
--KTVTWKVKKK------------------------------------------------
------------------------------------------------------------
-----------KDKTNARVMAQAKTELPA-GPALVPHTESDALPTSVV--ITVTKSEVKV
D-----------------------------------------------------------
-------TGIEASVKGAAKAT-----DKRSIKHKPEI-----------------------
--------KKEVCVKSR----------TGDKA-------------KE---VCVKSSAG--
------------------------D--------------------------------K--
-AKEVC-------------------------------VKSRAGD--KAK-----------
EVCVKSRAGDKASIVI-----------------------------NTTDEDEDYVCSWFW
TGEE------------------------PSVGSWFWPKEENPLQV---------------
-----YQPPPK---------------------V-EEEP----------------------
------------------------------------------------------------
----------------------EP-PD-----------------------TFDYALKKKA
-AAW----LRG--RFIVLVPIE------------EP--QPS-LPP---------DGNWTL
VATLIET--------PLGIRPLTKIPPYGGPYFQTLAD------LKNQIREKEKYGPNPN
TCRCKS-----RTFSLEPVEFDKLVTLLKLTRDPFIHEIATMIMGISPAYPFTQ------
----------DIVHDVGITVMIENFVNNPNAKK------YP-RTLNIN-AD-PDAPEEVK
ETEAHVNKVCRDILCCPLNCSVQVEELKLLVSLSVKFDYHHVVIYYVRYF-ISLLNKGSV
K-IK-FQILRVLLCLSKNQANTRELISAE---VMSSLVALFHKNESK----------ANI
LHIIEIFENINFQFKKRAKLFTK--------EM-FTK--SELI-SIFREAKEFDQKLQDL
T-DHSDPDVRDKVIRLILKL----------------------------------------
-------------------------------------------

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---------------------------------MGGPRGAGWVAAG----------LLLG
AGACYCIYRLT--RGRRR-GDR---------ELGIRS--SK-------------------
------------------------------------------SA----------------
------------------------------------------------------------
-------------------------------GA-LE---EG-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------TS-------------------------------
------------------EGQ-L----CRRS--------------AR---------P-QR
GG---------------TWESQ------------WSKTSQ--------------------
-----------PE--------------------------------------------DLT
DGSYD--------DVLNAEQLQKLLYLLESTEDPVIIERALITLGNNAAFSVNQ------
----------AIIRELGGIPTVANKINHSNQSI------KE-KALNALNNL-SVNVENQI
KIKIYISQVCEDVFSGPLNSAVQLAGLRLLTNMTVTNDHQHMLHSYITDL-FQVLLTGNG
N-TK-VQVLKLLLNLSENPAMTEGLLRAQ---VDSSFLSLYDSHVAK----------EIL
LRVLTLFQNIKNCLKIEGHLAV---------QPTFTE--GSLFFLLHGE--ECAQKIRAL
A-DHHDAEVKEKVVTIIPKI----------------------------------------
-------------------------------------------

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---------------------------------MGRTREAGCVAAG----------MVIG
AGACYCVYRLT--WGKDE-NEKLWD----DEDEEE-E--EEEESC---------------
------------------------SGKPEIGGKTV------KERKTHVGVGAGAKPQDDS
-----------------------------KS------------KAEANVGPENGPDVKKE
VYP----------------E--------SHSEGGLE---AKA------------------
-----------------KALFKS-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------L----------------------------------
----------------KEQASAKAGRGIRFPNIS--------------------------
---------------------------------------------RIRTLTSSLPCPGGR
GG---------GCHPGRTGSRA---------------------------------RNRTS
GKVKRKNRSKSNKAPA-T---------------------------AW----PVRRGKFSF
PYKID--------DILSAPDLQKVLNILERTNDPFTQEVALVTLGNNAAYSFNQ------
----------NAIRELGGVPIIAKLIKTRDPII------RE-KTYNALNNL-SVNSENQG
KIKTYISQVCDDTMVCRLDSAVQMAGLRLLTNMTVTNHYQHLLSYSFPDF-FALLFLGNH
F-TK-IQTMKLIINFTENPAMTRELVSCK---VPSELISLFNKEWDR----------EIL
LNILTLFENINDNIKSEGLASS---------RKEFSR--SSLFF-LFKESGVCVKKIKAL
A-SHKDLVVKVKVLKVLTKL----------------------------------------
-------------------------------------------

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---------------------------------MSRVRDAGCVAAG----------IVIG
ASAWYCVYKYA--RGRNHMMKKRLA----KPKTRA--VAETGARARAGLRAGFTIDLGPG
FSPPTPVRTGAEER-AQDESSALDTAGAEAVVPAA------SRAETQSGAGNKAQETEGA
--RLGPKAES---VATVASAVAPPLWEAKAP------------SAAKPPAMVGAPKSAEA
PGV----------------A--------EAPRAPVVPHVVPVPTEASPPTEAV-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------EASI------------PAMPT---------
------------------------------------------------------------
------------------------------------------------GAAATLGV----
---AA-----------PSGTA-----------------E-AP------------------
----------------------GPSGSSR-------------------------------
-----------TAA-----AAKKATPGPHTGAIPKAGS--ATGA---VLKGGA-------
-----------KGVTRSRTGG-K----GKGK-------------K-NKVEVDELGLGFRP
GD---------GAAAAAAASAN------------GGQAFLAEVPDS-----EEGESGWTD
TESESDSEPETQQKGKG----------------------------KR----SVPMQKRPF
PYEID--------EILGVRDLRKVLALLQKSDDPFIQQVALLTLSNNANYSCNQ------
----------DTIRKLGGLPIIANMINKTDPHI------KE-KALMAMNNL-SENYENQG
RLQIYMNKVMDDIMASNLNSAVQVVGLKFLTNMTITNDYQHLLVNSIANF-FRLLSQGGG
K-IK-VEILKILSNFAENPDMLKKLLSTQ---VPSSFSSLYNSYVES----------EIL
INALTLFEIIYDNLRAEVFN-----------YREFNK--GSLFY-LCTASGVCVKKIRAL
A-DHHDLLVKVKVIKLVDKF----------------------------------------
-------------------------------------------

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-------MTGAEIESAAQVKPEKKPGEEV--------VG-----------GAERENEVPL
VVRPKV--------------------------RTQ--ATTGAKPKTETKSVPRARPKTEA
------QAMSGA------------GPKT----------------------------DPQV
MGGARPKT----------------------------EAQGTAGARPKTN------ARAVG
GARPKT--DAKAITGARTKDEA--------------Q--------------SWGQTEFG-
-----TEVVSQAEGVSQTNAVAWPPATPES--GSVTKSKGLSMDRELVNVDAETFPGTQ-
-GQKGIQPWFGPE-EETN------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
---MGSWCYSRPRAR-EKAS-ESGFCSADETSTMSSFWAGEETSIRSWPREES---NTRS
RHRAKHQ-----T--NPRSGPRPQQEAYVEF-WSGSE-----------------------
-EEAGNPFS-WAGENTNNLF----------------------------------------
---------------------GPRVKEEANIRSKPRTKREDC--FESESE------DEFY
EKSFSLPREEA---------NSR-----FKRRDKEDPNTNLKSR----------------
AQ----KDV-NGDRVKQEPRF-----EEEVIIGSWFWAENEA------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------SL
EGR------ASAICESEPGTE-----EGAV------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------GGSLYWSEEQS
RLGA--------------------------------------------------------
-----------------------------------------------VARQEAKPES---
------------------------------------------------------------
------------------------------------------------------------
-EEDAIFGSWFWDRDEACFDL-NPCPVYKVSDRFRDTAEEELNASSRPQTWEEVTVEFKP
-GLF----HGVGFPSTSPFRFTEDAS-----EMFEAKPKNLELSPEG----E--EQESLL
QPDQ--PSPEFTFQYDPSY--------------------RSVREIREHLRAKESAEPENW
SCSCIQ-----CELKIGPEEFEELLILMDKIRDPFIQEISKIAMGMRSASQFTR------
----------DFIRDSGVVSLIETLLNYPSSRV------RT-SFLENMIHM-APPYPNLN
MIETFICQVCEETLAHSVDSLEQLTGIRMLRHLTMTIDYHTLIANYMSGF-LSLLTTANA
T-TK-FHVLKMLLNLSENPAVAKHLFSAK---ALSIFVGLFNIEETN----------DNI
QIVIKMFQNISNIIKSGKMSLID---------DDFSL--EPLI-SAFREFEELAKQLQAQ
IDNQNDPEVGQQS-----------------------------------------------
-------------------------------------------

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-----------TV-------------------------------------------TDKS
PPESP--------HTMDADALQKLTHLLQATDDPLIQEQALITLSNSAAFSVNQ------
----------DIIRNLDGLSVIGGMLSDCVPKV------TE-KALNALNNL-SMNIKNQE
EIQVYIEQVCKNVESAPLNSDLQLAGLRLLTNMSVTSDYHHKMINQIPCL-LRVLSEGSE
R-TQVIQVLKVLVNLSANPAMTRHFLRAQ----MPSLLLLFDNCMNK----------DIL
LRALVFAANLKKNVNNEGGSMI---------QDQYSE--DSVFSILCRDSTPFAQKLASL
W-HHPDPEVKEQVVRILTR-----------------------------------------
-------------------------------------------

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-----------------------------------------------MGRARE--VGWMA
AGLM----IGAGACYCVYKLTI------------GR--DDSEKLEE------EGEEEWDD
DQELDEEEPDIWFDFETMARPWTEDGDWTEPGAPGGTEDRPSGGGKANRA--HPIKQRPF
PYEHK--------NTWSAQNCKNGSCVLDLSKCLFIQGKLLFAEPKDAGFPFSQ------
----------DINSHLASLSMARNTSPTPDPTV------R--EALCAPDNL-NASIESQG
QIKMYINEVCRETVSRCCNSFLQQAGLNLLISMTVINN---MLAKSASDLKFPLISEGSG
C-AK-VQVLKPLMGLSEKPVLAGELVGAQ---MLFSFMSLFIRNGNR----------EIL
LETPAP------------------------------------------------------
------------------------------------------------------------
-------------------------------------------

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---------------------------------------MAGAKN--ESRNKAKTEKR-A
GIAAE--AKREVSGI------VKSV---------------------AKTQAKAIAKTRSQ
-----ADAV---------------------------------------------------
------AETKAV-------------SKIRIVTKTKKGALADFSPKAESEATR---VSQFC
SV---AEA----------------------------SAES-----RSPCKNKAGIDAWFW
AGEE------------------------GSVGSWFWNGEEAGN-HSSA------------
---------KDEDK-------ADSGPLSCA----E-------------------------
------------KLEPVGRASCKARPGAEE------------------------------
EEEENVIGNWFWDGDETSFDP-NPRPVSRIVRPQP---VDEINEKSRPKDWSEVTIWPKA
PAVTP---AVLGFRSQAPFETKPPS----YIVLASAEENAHSLPVA-----T--ASPSRS
TPSCSQPIPEYPFGSDPCI--------------------QTIEEIRRQIRIREVNGIKPF
ACPCKM------ECYMDSEEFEKLVNLLKSTTDPLIHKIAQIAMGIINVHPFAQ------
----------EFINEVGVVTLIESLLSFPSSEI-------RKKAVITL-NP-RSGDERQR
KIELHVKHMCKETISFPLNSPGQQSGLKILGELTTDSDHHYIVANYFSEL-FHLLSLGNR
K-TR-NLVLKVLLNMSENPTAARDMINSK---ALAALKLIFNQKEAK----------ANL
VSAVAIFINIKEHIRKGSIVVVD----------HLSY--NTLM-AIFREVKVIIETM---
------------------------------------------------------------
-------------------------------------------

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---------------------------------MGGPRGAGWVAAG----------LLLG
AGACYCIYRLT--RGRRR-GDR---------ELGMRP--SK-------------------
------------------------------------------SA----------------
------------------------------------------------------------
--------------------------------GILE---EG-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------TS-------------------------------
------------------KGQ-L----CGRS--------------AR---------P-QR
GG---------------TWESQ------------WSKTSQ--------------------
-----------PE--------------------------------------------DLT
DGSYD--------DVLNAAQLQKLLYLLESTEDPVIIERALITLGNNAAFSVNQ------
----------AIIRELGGIPIVGNKINHSNQSI------KE-KALNALNNL-SVNVENQI
KIKIYINQVCEDVFSGPLNSAVQLAGLRMLTNMTVTNDHQHMLHNYITDL-FQVLLTGNG
N-TK-VQVLKLLLNLSENPAMTEGLLHAQ---VDSSFLSLYDSHVAK----------EIL
LRVLTLFQNINNCLKIEGHLAV---------QPTFTE--GSLFFLLHGE--ECAQKIKAL
V-DHHDAEVKEKVLTIIPKI----------------------------------------
-------------------------------------------

------------------------------------------------------------
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-------MTGAEVEPVAQAKPEKKPGEEVV--------G-----------GAERENEVPM
VVRPKV--------------------------RNQA--TSGARSKTESKA----------
--------MAGARPKTESQTVAGARPRT----------------------------ESQP
MAGARPKT----------------------------EFQAMAGARPKTE------ARAVG
RARPKT--EARAIPGARPKDEA--------------Q--------------VWAQTEFG-
-----AEAMLQAEGMPQTSVVAWPLVSTES--GSVTKPMALSVDRELVNVDSETFPSSQ-
-VQTGIQPWFGSG-EETS------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---MGSWCYPRAKAR-EEASSESGFWSADETSTMSSFWAGEEASIRSWPREEA---NTRS
RHRAKHQ-----P--NPRSRPRSKQDPFIDS-WSGSE-----------------------
-EESGNPFCLWAGENTNNLF----------------------------------------
---------------------RSRIRDEANMRSKLRAKREDF--FESESE------DEYY
KESWFLPEEEA---------NSR-----FRPRDKEEPNTVLKPR----------------
TQ----KVVNNSDRVKQEPRF-----EEEVIIGSWFWAEKEA------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------SM
EAG------ASAICESEAGAE-----EGAI------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------GGSLFWTEENS
SLGA--------------------------------------------------------
-----------------------------------------------VAREETRPES---
------------------------------------------------------------
------------------------------------------------------------
-EEEAIFGSWFWDRDEACFDL-NPRPVYKASPRFRDAAEEEVNVSSRPKTWEEVTVEFKP
-GPC----HGVGFPSPSPFRIPEEATT-------SGKPKNVEVTPEG----E--EQESLL
QSDQ--PDSEFPFQYDPSY--------------------RSVREIREHLRAKESAQPESW
SCSCIQ-----CELKIGPAEFEELLLLMDKIRDPFIHEISKIAMGMRTASQFTR------
----------DFIRDSGVVSLIETLLNYPSSRV------RT-SFLENMIHM-APPYPNLN
MIETFVCQVCEETLAHSVGSPEQVLGLRMLRHLTSTTDYHTLVSNYMSGF-LSLLTTGNA
R-TK-FHVLKMLLNLSENPMVAKKLFSAK---ALSIFVGLFNIEETN----------DNI
QIVIKMFQNISNIIKNGTMALID---------DDFSL--EPLI-SAFHEFEKLAEELQVQ
INNQSDPEVGQQS-----------------------------------------------
-------------------------------------------

------------------------------------------------------------
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-------MTGTEVEPGAQAKPEKKAGEEG--------VG-----------GPEN--EVPL
VVRPKV--------------------------RPQTQVTPEANPKTESKSVPGARPKNES
------TATSG----------------------------------------------ASA
MAGARPKT----------------------------ESPAVVGARPKIE------GRAVG
AAQPKT--EANAIPGARTKDDA--------------L--------------AWSQTEFG-
-----VHAMSQSDGTSQTNAVTWPLVSTDS--GSGTTSNGLSMVEEVVNADTESFSGSQ-
-GQTGLQPWFGQR-EETN------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---GGSWCHPRPRAR-EEASNESGFGSADETSAVSSLWAGEETSIRSWPREEA---NTRS
THRAKHQ-----T--NPKTRPRSKQETYFES-WSGSE-----------------------
-EEAGNPFSFWAGENTNNLF----------------------------------------
---------------------RPKMREETNIRSKLKTKKEEC--FESESE------DEYY
KESWFLPGEEP---------KSR-----FRPKDKEEPNDILKSR----------------
AQ----KDTKHNDRAEQETRY-----EEEVIIGSWFWAEKEA------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------SL
EAG------AAAICDSESGAE-----EGAI------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------GGSLFWTEEKS
SLGA--------------------------------------------------------
-----------------------------------------------LAREEARPES---
------------------------------------------------------------
------------------------------------------------------------
-EEEAVFGSWFWDRDEACFDL-NPSPVYRVNCRFRDSVVEEPSVSTRPQTWDEVTVQFKR
--PC----RAIGFPPITSFRIPEGSD-----EVIEAKPKNL----EG----E--EEEFLF
APDQ--FESVYPFQYDPSY--------------------RSVQEIREHFKIRENADPENW
SCSCIQ-----CELKIGAAEFEELLLLMDKIRDPFIQEISKIAMGMRSASQFTR------
----------DFIRDSGVVSLIETLLNYPSSRV------RT-SFLENMIHL-APPYPNLN
MIETFICQVCEETLAHGVDSPEQLTGIMMLRHLTMTTDYHTLVANYMSGF-LSLLTTGNA
R-TK-FHVLKMLLNLSENLKVAKKLFSAK---ALTIFVGLFNIEETN----------DNI
QIVIKMFRNISNIIRSGAMAFID---------DDFSL--EPLI-SAFHEFEELAKQLQVQ
IDNQNDPKVGQ-------------------------------------------------
-------------------------------------------

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---------------------------------MGYARKVGWVTAG----------LVIG
AGACYCIYKLT--RGRKQNKEK-MA----EGGSGDVD--DAG----------------DC
---------------------------------------------------------SGV
--RYNDWSDDD-------------------------------------------------
DDD----------------N--------E-------------------------------
------------------------------------------------------------
-SKDIVWYPPWAR-----------------------------------------------
------------------------------------IG----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------T--------------------------------
-----------EAGTRARARA---------------------------------------
------------------------------------------------------------
-------------RARAN---------------------------RA----RRAVQKRAS
PNSDD--------TILSPQELQKVLCLVEMSEKPYILEAALIALGNNAAYAFNR------
----------DIIRDLGGLPIVAKILNTRDPIV------KE-KALIVLNNL-SVNAENQR
RLKIYMNQVCDDTVTSRLNSSVQLAGLRLLTNMTVTNEYQHILANSISDF-FRLFSAGNE
E-TK-LQVLKLLLNLAENPAMTRKLLRAQ---VPSSLGSLFSKKENK----------EII
LKLLVILENISDNFKWEENEPT---------QNQFGE--GSLFY-LLKEFQVCADKVLGI
E-SHHDFLVKVKVGKFMTKLAEHMFPKSQE------------------------------
-------------------------------------------

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---------------------------------MSRVRDAGCVAAG----------IVIG
AGAWYCVYRYT--RGRDQ-KKKRQA----KPKNRA--TVGTGTKARAGLRAGFTIDLGPG
FNPPTPLSAEAVNK-AQDEASTVDPAVAEEVVPAA------PSPEVQKEAEGQVQKADGA
--GNEPKTELV-TVPAVTSAVTPPPKVAEVS------------TATEAP--AGAPKMAET
PST----------------T--------EAPGSAAP-PLAAAPPRAAAPPGPAAPS----
-----------------GAVASPG--------------PAAP------------------
---------P----------------------------------------------GPAA
PPGPA----------APP------------------------------------------
------------------------------------------------------------
---------------------------QAVAPPRAVAPPGTAQSPGAAAPPRVVQSPGSA
MPPKTGAPPGTPVPPKVPATPR---ASAFTGAPAPPRAQAPPRGMAPTQRVAVTEVVEGP
RVVAPTEAAEIPRIAAL------------------------------AVVADGPVP----
---IM-----------LAGAI-----------------E-AP------------------
----------------------GTSGSSR-------------------------------
-----------TAP-----APKKATPGAHTGAIPKAGS--ATGA---VPKGG--------
-------A---KGGSRSRNGG-K----GKGK-------------K-NKVEVDELGMGFRP
GD---------GAAAAAAASAN------------GGKAFLAEVPDS-----EEGESGWTD
TESDTDSEPEVHHRGKG----------------------------KR----TIPMHKRPF
PYEID--------EILGVRDLRKVLALLQKSDDPFIQQVALLTLSNNANYSCNQ------
----------ETIRKLGGLPIIANMINKTDPHI------KE-KALMAMNNL-SENYENQG
RLQVYMNKVMDDIMASNLNSAVQVVGLKFLTNMTITNDYQHLLVNSIANF-FRLLSQGGG
K-IK-VEILKILSNFAENPDMLKKLLGTQ---VPSSFSSLYNSYVES----------EIL
INALTLFEIIYDNLRAEVFN-----------YREFNK--GSLFY-LCTTSGVCVKKIRAL
A-NHHDLLVKVKVIKLVNKF----------------------------------------
-------------------------------------------

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------------------------------------------------------------
---------------------------------MGGPRGAGWVAAG----------LLLG
AGACYCIYRLT--RGRRR-GDR---------ELGMRP--SK-------------------
------------------------------------------SA----------------
------------------------------------------------------------
---------------------------------------EG-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------TS-------------------------------
------------------KGQ-L----CERS--------------AR---------P-QR
GG---------------TWESQ------------WSKTSQ--------------------
-----------PGNGN-------------------------------------K---DLT
DGSYD--------DVLNAAQLQKLLYLLESTEDPVIIERALITLGNNAAFSVNQ------
----------AIIRELGGIPIVGNKINHSNQSI------KE-KALNALNNL-SVNVENQI
KIKIYINQVCEDVFSGPLNSAVQLAGLRLLTNMTVTNDHQHMLHSYITDL-FQVLLTGNG
N-TK-VQVLKLLLNLSENPAMTEGLLHAQ---VDSSFLSLYDSHVAK----------EIL
LRVLTLFQNINNCLKIEGRLAV---------QPTFTE--GSLFFLLHGE--ECAQKIKAL
V-DHHDAEVKEKVLTIIPKI----------------------------------------
-------------------------------------------

------------------------------------------------------------
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-----------------------------------------------MGRARE--MGWMA
AGLM----IGAGACYCMYKLTM------------GR--SEGNELED------EEEDEWED
GQDLDEEEADNWFDFTAMARPWSEDGDWDEPGAPGGTEDRRSGGGKANRA--HPIKQRPF
PYEHK--------NIWGEQSFKSFTCILDLNKCVSTQRKKRFTKNINAGFSLSP------
----------NISKHLASLSVVGNRSPTPHPTV------RE-KALFVPENP-NSSLENQG
QIKMSIDEVCRETLLCCCKSFLQQAGLSLLISMTVINN---MLAKSVSDLKFPLLSKGSG
C-AE-VRGLEELMSLSEKPVLVGEALAAQ---MLSSFMCLFTRSGSR----------EML
VEAISP------------------------------------------------------
------------------------------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
-----------------------------------------------MGRARE--VGWMA
AGLM----IGAGACYCVYKLTV------------GR--NESEKLEE------E-EEEWDD
DQELDDEEPEIWFDFTTMARPWSEDGDWTEPGAPGGTEDRPSGGGKANRT--HPTKQRPF
PYEHK--------NTWGAESFKNCRCVLNLSNYPFIQGKMLSAQSKDAGFSFSH------
----------DINSHLACLSIVGNTIPICDPAV------KE-KALCTLDNV-NVSVENQG
QIKMYINEVCRETVSHCCNSFLQQAGLNLLISMTVINN---TLAKSVSDLKFPLISEGSG
C-AE-VQVLKPLTALSEKPVLAEELLGAQ---MLLSCMSLFIRNGNR----------QVL
LDILAS------------------------------------------------------
------------------------------------------------------------
-------------------------------------------

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------------------------------------------------------------
------------------------------------------------------------
---------------------------------MGRTREAGCVAAG----------VVIG
AGACYCVYRLT--WGRDE-NEIIWN----EDDDEEGE--SHD------------------
------------------------------ISETG------KGAKANAGAGAGARL-QGE
--S--------------------------KA------------KAEVAVELKSGPDVKAE
AHS----------------K--------AERGGGLE---AKA------------------
-----------------KALFST-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------L----------------------------------
----------------KEQASAKAVKAAKLGTI---------------------------
------------------------------F--------------GTRALAPGLPCPGVR
GG---------GCHPVRNGARA---------------------------------GSKAS
GKSKGRARNKSTRTPA-M---------------------------LW----PVRKGKFNF
PYKID--------DILGATDLQKVLNILERSNDPFIQEVALVTLGNNAAYSFNQ------
----------NAIRELGGLPIIAKLIKTKDPII------RE-KAYNALNNL-SVNSENQG
KIKTYISQVCDDTMICRLDSAVQMAGLRLLTNMTVTNHYQHLLSYSFPDF-FALLFLGNY
F-TK-IQIMKLIINFTENPAMTRELVSCK---VPSELISLFNKEWDR----------EIL
LNILTLFENINDNIKNEGLASS---------RKEFSR--SSLFF-LFKESGVCVKKIKAL
A-NHSDLVVKVKVLKVLTKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
---------------------------------MGRTREAGCVAAG----------VVIG
AGACYCVYRLT--WGRDE-SEKIWD----DDEEDDEE--EASDIV---------------
----------------------------KTGVETG------RGTKANAGVGAGARLQGE-
----------------------------SKV------------KAEVGLELQSGSDVKAE
AHM----------------G--------AQSGGGLE---AKA------------------
-----------------KALFST-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------L----------------------------------
----------------KEQASAKVGRGARLGTIS--------------------------
---------------------------------------------GNRTLAPSLPCPGVR
GG---------GCHPTRSGARA---------------------------------GGRAS
GKTKGRTRGKSTRTPA-T---------------------------AW----PVRRGKFNF
PYKID--------DILGASDLQKVLNILERSNDPFIQEIALVTLGNNAAYSFNQ------
----------NAIRELGGLPIIAKLIKTKDPII------RE-KAYNALNNL-SVNAENQG
KIKTYISQVCDDTMICRLDSAVQMAGLRLLTNMTVTNHYQHLLSYSFPDF-FALLFLGNY
F-TK-IQIMKLIINFTENPAMTRELVSCK---VPSELISLFNKEWDR----------EIL
LNILTLFENINDNIKNEGLASS---------KKEFSR--SSLFF-LFKESGVCVKKIKAL
A-NHNDLVVKVKVLKVLTKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
---------------------------------MGRTREAGCVAAG----------VVIG
AGACYCVYRLA--WGRDE-NEKIWD----EDEESTDT--SE-------------------
-----------------------------TGVETV------KGAKTNVGAGSGAKLQGDS
-----------------------------KV------------KPEVSLGLEDCPGVKEK
AHS----------------G--------SHSGGGLE---AKA------------------
-----------------KALFNT-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------L----------------------------------
----------------KEQASAKAGKGARAGTIS--------------------------
---------------------------------------------GNRTLAPSLPCPGGR
GG---------GCHPTRSGSRA---------------------------------GSRAS
GKSKGKARSKSTRAPA-T---------------------------TW----PVRRGKFNF
PYKID--------DILSAPDLQKVLNILERTNDPFIQEVALVTLGNNAAYSFNQ------
----------NAIRELGGVPIIAKLIKTKDPII------RE-KTYNALNNL-SVNAENQG
KIKTYISQVCDDTMVCRLDSAVQMAGLRLLTNMTVTNHYQHLLSYSFPDF-FALLFLGNH
F-TK-IQTMKLIINFTENPAMTRELVSCK---VPSELISLFNKEWDR----------EIL
LNILTLFENINDNIKNEGLASS---------RKEFSR--SSLFF-LFKESGVCVKKIKAL
A-NHNDLVVKVKVLKVLTKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------MTGAEIETGAQAKSEKKAGEEV--------VS-----------GAERENEVPL
VVRPKV--------------------------RAQAQVTTGARPKTETKSASGARPKTEA
------QKVAGA------------RPKT----------------------------EAQT
MAGARPKT----------------------------ETQAMAGARPKTD------ARAVG
GARPKS--EAKTVSGARPKDDA--------------Q--------------AWAQTEFG-
-----TEAMSQAEGASQTNAVTWPLVNTDS--GSVTKSKGLPVDRELVSLDAETFPGNQ-
-GQAGIQPWFGPG-EETS------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---MGSWCYPRPRAR-EEASNESGFWSADETSTVSSFWAGEEASIRSWPREEA---NTRS
RHRAKHQ-----T--NPRSKSTSKQEPYIDS-WSGSE-----------------------
-DESGNPFCFWAGENTNNLF----------------------------------------
---------------------RPRAREEANVRSKLRTKREDY--FESESE------DEFY
KESWFLPGEEA---------NNR-----FRRRDKEEPNNILKSR----------------
AQ----KDDKNIDRAKQEPRF-----EEDVIIGSWFWAEKEA------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------SL
EAG------ASAICESEPGAE-----EGAI------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------GGSLFWAEEKS
SLGA--------------------------------------------------------
-----------------------------------------------VAREETRPES---
------------------------------------------------------------
------------------------------------------------------------
-EEEAIFGSWFWDRDEACFDL-NPSPVYKANCRYRDPAEDELNASSRPQTWEEVTVEFKP
-GPC----HGVGFPSTSPFRIPEGSS-----EMNEAKSKNVELGPEG----E--EQESSL
QSDR--AEPEFPFQYDPSY--------------------RSVREIREHLRARESAEPENW
SCSCIQ-----CELKIGSGEFEELLLLMDKIRDPFIHEISKIAMGMRSASQFTR------
----------DFIRDSGVVSLIETLLNYPSSRV------RT-SFLENMIHM-APPYPNLN
MIETFICQVCEETLAHGVDSLEQMTGIRMLRHLTMTTDYHTLIANYMSGF-LSLLTTGNA
R-TK-FHVLKMLLNLSENPMVAKKLFSAK---ALSIFVGLFNIEETN----------DNI
QIVIKMFQNISNIIKSGALSLID---------DDFSL--DPLM-SAFHEFEELAKDLQVQ
IDNQNDPEVGQHS-----------------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MTGTKN--KTRAQAKTEKK-P
VTQAKAGAEREAPGV------VRPV---------------------AKTRAKAKAKTGSK
-----TDAV---------------------------------------------------
------AEMKAV-------------SKNKVVAEVKEGALSEPKTLGRAM-----------
-----GDF----------------------------SSKAGNESTSSTCKNEAGIDAWFW
AGEE------------------------ATINSWFWNGEEAGN-SSST------------
---------KNDKP--------EIGAQVCA----E-------------------------
------------ELEPAAGADCKPKSGAEE------------------------------
EEEENVIGNWFWEGDDTSFDP-NPKPVSRIVKPQP---LYEINEKNRPKDWSEVTIWPNA
PAVTP---AVLGFRSQAPSEASPPS----YIVLASAEENACSLPGA------TACRPSRN
TRSCSQPIPECRFDSDPCI--------------------QTIDEIRRQIRIREVNGIKPF
ACPCKM------ECYMDSEEFEKLVSLLKSTTDPLIHKIARIAMGVHNVHPFAQ------
----------EFINEVGVVTLIESLLSFPSPEM-------RKKTVITL-NP-PSGDERQR
KIELHVKHMCKETVSFPLNSPGQQSGLKILGQLTTDFVHHYIVANYFSEL-FHLLSSGNC
K-TR-NLVLKLLLNMSENPTAARDMINMK---ALAALKLIFNQKEAK----------ANL
VSGVAIFINIKEHIRKGSIVVVD----------HLSY--NTLM-AIFREVKGIIETM---
------------------------------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MTGSKN--KAKAQAKLEKK-A
SAQAKAIAEREASHA------GRAS---------------------GKNRDKGKAKGGAK
-----ADAV---------------------------------------------------
------AEMKAG-------------SKSKT--E----MREGAKGLGKGS-----------
-----SDF----------------------------SHKSENKAARATRKEKASSDTWFW
AGED------------------------SGLNSLFWKGEELST-NSVA------------
---------RCENK-------TYNVPQSRP----E-------------------------
------------ESEPAPRTSHRSKSGPEE------------------------------
EEEENVIGNWFWEGDDTGFDP-DPKPVFRIIKPQP---VDEINEKNRPKDWSEVTIWPKA
PAVIP---AVLGFISKDSSEARPSS----YIVLASNEEETST------------TACTKN
ARSSLQPIPEYPFGSDPCI--------------------QTLDEIKQQIKIRETNGIKPF
ACACKM------ECYLDSPEFEKLVNILKSTTDPLIHKIAQIAMGIHKVHPFAR------
----------EFINEVGVVTLIESLLSFSSPES-------RNKTVITL-N--SSGNDRQH
KVEFHVRHMCKETVSFPLNSPGQQSGLKIIGQLTTESVHHYIVVSYFSEL-FHLLSQGNR
K-TR-NLVLKVFLNMSENPKAARDMINMK---ALAALKLIFNQKEAK----------ANL
VSAVAIFINIKEHIRKGSIVVAD----------HMSY--NTLT-AIFREVKCIIERM---
------------------------------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------MVDSGTEARARGKAEAGLQDG--------ISGP----
------AAARVNGKTQAKAVA-----EAELKTESV----TQAKAGDGAMTRTHTVTYREA
--MAVTREVIKV------------------------------------------------
------------------------------------------------------------
-----------EDTTKTRVMVQTKTKPLA-ERSIVPQTKSRAMPISRV--STVTKSEVKV
V-----------------------------------------------------------
-------AVIEANIKSYAKSH-----DKANTGSRPDR-----------------------
--------REEA------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------SIGM-----------------------------KSSDEDEENICSWFW
TGEE------------------------PSVGSWFWPEEETSLQV---------------
-----YKPLPK---------------------I-QEKP----------------------
------------------------------------------------------------
----------------------KPTHK------------------------PTLTIKQKV
-IAW----SRA--RYIVLVPVE------------GG--EQS-FPP---------EGNWTL
VETLIET--------PLGIRPLTKIPPYHGPYYQTLAE------IKKQIRQREKYGPNPK
ACHCKS-----RGFSLEPKEFDKLVALLKLTKDPFIHEIATMIMGISPAYPFTQ------
----------DIIHDVGITVMIENLVNNPNVKE------HP-RALSMVDDS-SESSEGPK
SGESYIHQVCKGILSCPMNSPVQLAGLKLLGHLSVKFEDHYVITSYIPDF-LTLLNKGSV
K-TK-FYVLKVFSCLSKNHANTRELISAK---VLSSLVAPFNKNESK----------ANI
LNIIEIFENINFQFKTKAKLFTK--------EK-FTK--SELI-SIFQEAKQFGQKLQDL
A-EHSDPEVRDKVIRLILKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------MG--GKRNKGKTEKR-A
SVEAK--TKREAIGV------GRPV---------------------AKTQAKAIAKPEVK
-----ANAV---------------------------------------------------
------AQVKAV-------------SKKKIVTEKK-GAPANFSPKVEDEATQ---N----
----------------------------------------GEAETKSMCKDKAGIDSC--
AGEE------------------------TSVGSRFQNGEETDN-SSSA------------
---------KDEGK-------ADTGAPSCA----E-------------------------
------------KLEPVASASCKARPGAEE------------------------------
EEEENVIGNWFWDGDETSFDP-DPKPVSRILRPQP---VDEINEKDRPKDWSEVTIWPNA
PAVTP---AVLGFRSQVTSETKPPS----YIVLGSAEENARASPEE-------TESLSKS
IFSCSESLPEHPFGSDPCI--------------------QTIEQIRRQIKIREMNGIKPF
ACPCKM------ECYMTSEEFEKLITLLESTTDPLIHKVAQIAMGIIKVHPFAQ------
----------EFINEVGVVTLIESLLSFPSSER-------RKNAVFTL-NE-PGGLERHR
KVELHVKHMCKETMCFPLNSPGQQSGLKILGQLTTDVNRHHIVASYLSDF-YYLLSQGNR
K-TR-NLVLKVLLNMSENPVAAREMISSR---ALGALKLIFNQREAK----------ASL
VNAVAIFINIKEHIRKGSIVVVD----------QSSY--STLM-DLFREVKMIIETL---
------------------------------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
---------------------------------------MAGTKN--KTRAQAKTEKK-A
AIQAKAGAEREATGV------VRPV---------------------AKTRAKAKAKAGSK
-----TDAV---------------------------------------------------
------AEMKAV-------------SKNKVVAETKEGALSEPKTLGKAM-----------
-----GDF----------------------------SPKAGNESTSSTCKNEAGTDGWFW
AGEE------------------------ATINSWFWNGEEAGN-SSST------------
---------KNDKP--------EIGAQVCA----E-------------------------
------------ELEPAAGADCKPRSRAEE------------------------------
EEEENVIGNWFWEGDDTSFDP-NPKPVSRIVKPQP---VYEINEKNRPKDWSEVTIWPNA
PAVTP---AVLGFRSQAPSEASPPS----YIVLASAEENACSLPVA------TACRPSRN
TRSCSQPIPECHFDSDPCI--------------------QTIDEIRHQIRIREVNGIKPF
ACPCKM------ECYMDSEEFEKLVSLLKSTTDPLIHKIARIAMGVHNVHPFAQ------
----------EFINEVGVVTLIESLLSFPSPEM-------RKKTVITL-NP-PSGDERQR
KIELHVKHMCKETMSFPLNSPGQQSGLKILGQLTTDFVHHYIVANYFSEL-FHLLSLGNC
K-TR-NLVLKLLLNMSENPTAARDMINMK---ALAALKLIFNQKEAK----------ANL
VSGVAIFINIKEHIRKGSIVVVD----------HLSY--NTLM-AIFREVKEIIETM---
------------------------------------------------------------
-------------------------------------------

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------------------------------------------------------------
---------------------------------MGGARGAGWVAAG----------LLLG
AGACYCIYRLT--RGRRR-GGH---------GLGLRP--SK-------------------
------------------------------------------SAG---------------
------------------------------------------------------------
---------------------------------ALE---EG-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------TP-------------------------------
------------------EGQ-L----CGRS--------------AR---------P--R
GG---------------PWESQ------------WSKTSQ--------------------
-----------PE--------------------------------------------DLT
DGSYD--------DVLNAEQLQKLLYLLESTEDPIIIEKALITLGNNAAFSVNQ------
----------AIIRQLGGIPIVGNKINHSNQSI------KE-KALNALNNL-SVNVENQI
KIKIYINQVCEDVFSGPLNSAVQLAGLRLLTNMTVTNDHQHMLHNYITDL-FQVLLTGNG
N-TK-VQVLKLLLNLSENPAMTEGLLHAQ---VDASFLSLYDSHVAK----------EIL
LRVLTLFQNINNCLKIEGHLAV---------QPTFTE--GSLFFLLYGE--ECAQKIRAL
V-HHDDADVKEKVVTIMLKI----------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
-------MTGAEIEPSAQAKPEKKAGEEV--------VA-----------GPERENDVPL
VVRPKV--------------------------RTQ--ATTGARPKTETKSVPAARPKTEA
------QAMSGA------------RPKT----------------------------EAQV
MGGARPKT----------------------------EAQGMAGARPKTD------ARAVG
GARSKT--DAKAIPGARPEDEA--------------Q--------------AWAQSEFG-
-----TEAVSQAEGVSQTNAVAWPLATAES--GSVTKSKGLSMDRELVNVDAETFPGTQ-
-GQKGIQPWFGPG-EETN------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---MGSWCYSRPRAR-EEASNESGFWSADETSTASSFWAGEETSVRSWPREES---NTRS
RHRAKHQ-----T--NPRSRPRSKQEAYVDS-WSGSE-----------------------
-DEAGNPFSFWAGENTNNLF----------------------------------------
---------------------RPRVREEANIRSKLRTNREDC--FESESE------DEFY
KQSWVLPGEEA---------DSR-----FRHRDKEDPNTALKLR----------------
AQ----KDV-DSDRVKQEPRF-----EEEVIIGSWFWAEKET------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------SL
EGG------ASAICESEPGTE-----EGAI------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------GGSAYWAEEKS
SLGA--------------------------------------------------------
-----------------------------------------------VAREEAKPES---
------------------------------------------------------------
------------------------------------------------------------
-EEEAIFGSWFWDRDEACFDL-NPCPVYKVSDRFRDAA-EELNASSRPQTWDEVTVEFKP
-GLF----HGVGFRSTSPFRIPEEAS-----EMLEAKPKNLELSPEG----E--EQESLL
QPDQ--PSPEFTFQYDPSY--------------------RSVREIREHLRARESAESESW
SCSCIQ-----CELKIGSEEFEELLLLMDKIRDPFIHEISKIAMGMRSASQFTR------
----------DFIRDSGVVSLIETLLNYPSSRV------RT-SFLENMIHM-APPYPNLN
MIETFICQVCEETLAHSVDSLEQLTGIRMLRHLTMTIDYHTLIANYMSGF-LSLLTTANA
R-TK-FHVLKMLLNLSENPAVAKKLFSAK---ALSIFVGLFNIEETN----------DNI
QIVIKMFQNISNIIKSGKMSLID---------DDFSL--EPLI-SAFREFEELAKQLQAQ
IDNQNDPEVGQQS-----------------------------------------------
-------------------------------------------

------------------------------------------------------------
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---------------------------------MGRSRHVGWVAAG----------LVLG
AGACYCIYKLT--RGQRQ-GDR---------GLRLRP--SR-------------------
------------------------------------------SAE---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------DLT
DGSYD--------DILNVDQLQKLLYLLESTDDPIIIERALVTLGNNAAFSANQ------
----------VIIRELGGIPIIGSKINNPNHSI------KE-KALNALNNL-SVNVENQV
KIKVYINQVCKDVLSGPLDSAVQLAGLRLLTNMTVTNDHQHMLHNYITDL-FHVLLTGNG
S-TK-VQVLKLLVNLSENPAMAEGLLGAQ---VDSSFLSLYDGHVAK----------EIL
LRVLTLFQNINNCCKKEGCSAM---------QPTFPK--GSLFFLLYGE--ECAQKMRAL
V-DHHDADVKEKVQTLESAMGTIRDQKH----E-PSFSFQISSRQ---------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
--------GARAGIGI-----------------------------KSSDRDEENVCSWFW
TGEE------------------------PSVGSWFWPEEETAPQV---------------
-----CKPPPK---------------------I-QEKP----------------------
------------------------------------------------------------
----------------------KPT--SK----------------------PELTIKQKA
-AAW----SRA--RYSVLVPVE------------GG--ERS-LPP---------EGNWTL
VETLIET--------PLGIRPLTKIPPYNGPYFQTLAD------IKKQVRYREKYGPNPK
ACRCKL-----RSFSLEPKEFDKLVALLKLTKDPFIHEIATMIMGISPAYPFTQ------
----------DIIHDVGITVMIENLISNPNVKE------HP-RALNMVDDS-SESSEELK
SGESYINQVCKDILSYPLNSPVQLAGLKLLGHLSVKFEDHHMIASYIPDF-LTLLNKGSV
K-TK-FYVLKVFLCLSKNQANTRELISAE---VLSSLIAPLNKNESK----------ANI
LNVIAIFENINFQFKKKVKLFTK--------EQ-FTK--SELI-SIFQEAKEFGQKLQDL
A-EHSDPEVRDKVIRLILKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
---------------------------------MGRTREAGCVAAG----------VVIG
AGACYCVYRLA--WGRDE-NEKIWD----EDEESTDT--SE-------------------
-----------------------------TGVETV------KGAKTNLGAGSGAKLQGDS
-----------------------------KV------------KPEVSLGLEDCLGVKEK
AHS----------------G--------SHSGGGLE---AKA------------------
-----------------KALFNT-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------L----------------------------------
----------------KEQASAKAGKGARVGTIS--------------------------
---------------------------------------------GNRTLAPSLPCPGGR
GG---------GCHPTRSGSRA---------------------------------GGRAS
GKSKGKARSKSTRAPA-T---------------------------TW----PVRRGKFNF
PYKID--------DILSAPDLQKVLNILERTNDPFIQEVALVTLGNNAAYSFNQ------
----------NAIRELGGVPIIAKLIKTKDPII------RE-KTYNALNNL-SVNAENQG
KIKMYISQVCDDTMVCRLDSAVQMAGLRLLTNMTVTNHYQHLLSYSFPDF-FALLFLGNH
F-TK-IQTMKLIINFTENPAMTRELVSCK---VPSELISLFNKEWDR----------EIL
LNILTLFENINDNIKNEGLASS---------RKEFSR--SSLFF-LFKESGVCVKKIKAL
A-NHNDLVVKVKVLKVLTKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MGGARAAGWVAAG----------LALG
AGAGFCLYRLA--RGPRR-S----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------KRG------------LRSSE---------------------
--------------SA-------------------------------------E---DLT
NGSYD--------DILNAEQLQKLLYLLESTEDPVITERALVTLGNSAAFSGNQ------
----------AIIRELGGIPVVGNKINSPNHSI------KE-KALNALNNL-SVNVENQV
KIKVFVHQVCEDVMSGPLDSAVQLAGLRLLTNMTVTNEHQHMLSGYAADL-FRVLLTGNG
T-TK-VQVLKLLVNLSENPAMTEGLLTAQ---VDSSFLSLFDGHTAQ----------EIL
LRVLTLFQNINNCLRRGGLLAI---------RPPLPT--GSLFSLLYGE--DCVQKMKAL
V-YHHDVEVREKVLTVIPGF----------------------------------------
-------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------MGRARE--MGWMA
AGLM----IGAGACYCMYKLTM------------GR--SEGNELED------EEEDEWDD
EQDLDEEEADNWFDFTAMARPWSEDGDWDEPGAPGGTEDRRSGGGKANRA--HPIKQRPF
PYEHK--------NIWGEQSFKSFTCILDLKKCVSTQRKKMFTENTNAGFSLSP------
----------NVSKHLASLSVVGNRSPTTHPTV------RE-KALFVPENP-NSSLENQG
QIKMSIDEVCRETLLCCCKSFLQQAGLSLLISMTVVNN---MLAKSVSDLKFPLLSEGSG
C-AE-VRGLEELMSLSEKPVLVGEALAAQ---MLSSFLCLFTRSGSR----------EML
VEAISP------------------------------------------------------
------------------------------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------MTGAEIETGSHSKSDKKPQEEV--------MG-----------GANGEGEVPL
VVRPKV--------------------------RPQAPATSGARPKTETKS-SRARPKTET
------QSMSGT------------RPKN----------------------------DAQA
MTGARPRS----------------------------EAQIMTGARPKTD------GRAVG
GARPKT--EAKPIPGARPKDDA--------------Q--------------AWAQNEFG-
-----AEAMPQAERAPLSNAVTWPLVNSES--TYITKSKSLCMNRELVNMDNETFPGSQ-
-GQAGIPPWFGPG-EETN------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---TGSWCYPRPRAR-EETSNESGFWSADESSNMSSFWTGEEPSIRSWPREEA---NTRS
RHRAKHQ-----T--NARSRPRSKQDPYIDS-WSGSE-----------------------
-DEAGNPFCFWAGENTNELF----------------------------------------
---------------------RPRGREEANVRPKIRTKRDDY--FDSESE------DEFY
KESWFLPGEEA----------NR-----FRHRNKEESNNILKNR----------------
NQ----KDVKNGDRVKQESRF-----DEEVIIGSWFWAEHEN------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------SL
EAG------AAAICESELGAE-----EGAI------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------GGSLFWNEEKP
TLGA--------------------------------------------------------
-----------------------------------------------VARDEVRPES---
------------------------------------------------------------
------------------------------------------------------------
-EEEALFGSWFWDRDEACFDL-NPTPVYKAKSRFRDSAEEELNVSSRPKTWDEVTVEFKP
-GPC----HDFGFSSTNPFRIPEGDS-----ENAEAKAKNVELGAEG----E--EQEPVL
QRNL--REPEFPFQYDPSY--------------------RSVQEIREHLKARESADPENW
SCTCIQ-----CELKIGSAEFEELLLLMDKIRDPFIHEISKIAMGMRTASQFTR------
----------DFIRDSGVVSLIETLMNYPSSRV------RT-NFLENMIHM-APPYPNLN
MIETFICQVCEETLAHSVNSLEQLTGIRMLRHLTITTDYHTLIANYVSGF-LTLLTTGNA
R-TK-FHVLKMLLNLSNNPLVAKKLFSAK---ALSIFVGLFNIEETN----------DNI
QIVIKMFQNISNIVKSGAMSLVD---------EDFCL--EPLV-SAFHEFEELAKRLQIQ
IDNQNDPDEGQ-------------------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--MAMTREVSKM------------------------------------------------
------------------------------------------------------------
-----------EAKTKTRVVAETKSKPLV-EPSVVSQTKSKTMPVSKI--SAVIEYEVKA
G-----------------------------------------------------------
-------AASEPNIRSFARAD-----DKDNTQSRSQR-----------------------
--------RREASMKFR----------AG-------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------DGAGIVI-----------------------------ESS-DDEENACSWFW
TGEE------------------------PSVGSWFWPEEETPFQV---------------
-----YEPPPK---------------------I-PEKP----------------------
------------------------------------------------------------
----------------------KPTPKPK----------------------PELTIKQKA
-AAW----SRA--RYCVLVPIE------------GG--EGS-LPP---------EGNWTL
VETLIET--------PLGIRPLTKIPPYNGPYFQTLAE------IKKQVKYREKYGPNPK
TCRCKS-----RVFSLEPKEFDKLVALLKLTRDPFIHQIATMIMGISPAYPFTQ------
----------DIIHDVGITVMIENLVNNPNVIE------HP-RALNKVDDN-SGSSGQPK
TGELYVNQVCKEIISSPLNSPVQLAGLKLLVQLSVKFEDHHMIINYIPDF-LTLLNKGSV
K-TK-FYVLKVFSRLSKNQANTRELISAK---VLSSLVAPFNKNESK----------ANI
LNIIEIFENINFQFKKKVKLFTK--------EE-FTK--SELI-SIFQEAKEFGQKLQDL
A-EHSDPENSHSLEFQLWVLLSELGIFTIQLDKTPWKYSVSQMPYGTYT-----------
-------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
---------------------------------MGYARKVGWVTAG----------LVIG
AGACYCIYRLT--RGRKQNKEK-MA----EGGSGDVD--DVG----------------DC
---------------------------------------------------------PGA
--RYNDWSDDD-------------------------------------------------
DDN----------------S--------E-------------------------------
------------------------------------------------------------
-NKGIVWYPPWAR-----------------------------------------------
------------------------------------IG----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------T--------------------------------
-----------EAGTRARARA---------------------------------------
------------------------------------------------------------
-------------RARAT---------------------------RA----RRAVQKRAS
PNSDD--------TILSPQELQKVLCLVEMSEKPYILEAALIALGNNAAYAFNR------
----------DIIRDLGGLPIVAKILNTRDPIV------KE-KALIVLNNL-SVNAENQR
RLKIYMNQVCDDTITSRLNSSVQLAGLRLLTNMTVTNEYQHMLANSISDF-FRLFSAGNE
E-TK-FQVLKLLLNLAENPAMARALLRAQ---VPSSLGSLFTKKENK----------EVI
LKLLVIFENINDNFKCEETEPA---------QDQFSE--GSLFF-FLKEFQGCADKILGI
E-SHHDFLVKVKVGKFMAKLAERMFPKSQE------------------------------
-------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MSRVRDAGCVAAG----------IVIG
ASAWYCVYKYA--RGRNQ-TKKRLA----KPKTRA--MAGTGARARARLRAGFTIDLGPG
FGPPTPVRTQAENR-AQEEASALDTDGAEAVAPAA------TGAEVQSGAGHQVQEAEGA
--GAGPKA-EPVMGATGTSSMASPLGEAEAS------------VAAEAPTVARAPKLPEA
PGT----------------A--------EAPGVPTMPPSVPAPTEA-TA-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------PMEAAEAPV------------PTPP----------
------------------------------------------------------------
-----------------------------------------------TA-----VL----
---V------------PSGAA-----------------E-AP------------------
----------------------GTSGSPR-------------------------------
-----------SVA-----PSKKATPGAHTGAIPKAGS--ATGA---VPKGGA-------
-------K-----GTRSRTGG-K----GKGK-------------K-NKVEVDELGLGFRP
GD---------GAAAAAAASAN------------GGQAFLAEVPDS-----EEGESGWTD
TESESDSEPETQQRGRG----------------------------RR----PVPMQKRPF
PYEID--------EILGVRDLRKVLALLQKSDDPFIQQVALLTLSNNANYSCNQ------
----------DTIRKLGGLPIIANMINKTDPHI------KE-KALMAMNNL-SENYENQG
RLQVYMNKVMDDIMASNLNSAVQVVGLKFLTNMTITNDYQHLLVNSIANF-FRLLSQGGG
K-IK-VEILKILSNFAENPDMLKKLLSTQ---VPSSFSSLYNSYVES----------EIL
INALTLFEIIYDNLRAEVFN-----------YREFNK--GSLFY-LCTTSGVCVKKIRAL
A-DHHDLLVKVKVIKLVDKF----------------------------------------
-------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MGYARKVGWVTAG----------LVIG
AGACYCIYRLT--RGRKQNKEK-MA----DGGSGDKD--DAG----------------DC
---------------------------------------------------------PEV
--RYNDWSDDD-------------------------------------------------
DDN----------------S--------E-------------------------------
------------------------------------------------------------
-NKDIVWYPPWAR-----------------------------------------------
------------------------------------IG----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------T--------------------------------
-----------EAGTRARARA---------------------------------------
------------------------------------------------------------
-------------RARAT---------------------------RA----RRAVQKRAS
PNSDD--------TILSPQELQKVLCLVEMSEKPYILEAALIALGNNAAYAFNR------
----------DIIRDLGGLPIVAKILNTRDPIV------KE-KALIVLNNL-SVNSENQR
RLKIYMNQVCDDTITSRLNSSVQLAGLRLLTNMTVTNEYQHMLANSISDF-FRLFSTGNQ
E-TK-FQVLKLLLNLAENPAMHRELLRAQ---VPSSLGSLFNKKENK----------EVI
LKLLVIFENIIDHFKWEGNELS---------QNQFSE--GSLFF-FLKEFQVCADKILGI
E-SHHDFLVKVKIGKFMTKVTEQMIPKSQE------------------------------
-------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MGGPRGAGWVAAG----------LLLG
AGACYCIYRLT--RGRRR-GDR---------ELGMRP--SK-------------------
------------------------------------------SAGET-------------
------------------------------------------------------------
--A----------------G--------CPAGGILE---EG-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------TS-------------------------------
------------------KGQ-L----CGRS--------------AR---------P-QR
GG---------------TWESQ------------WSKTSQ--------------------
-----------PE--------------------------------------------DLT
DGSYD--------DVLNAAQLQKLLYLLESTEDPVIIERALITLGNNAAFSVNQ------
----------AIIRELGGIPIVGNKINHSNQSI------KE-KALNALNNL-SVNVENQI
KIKIYINQVCEDVFSGPLNSAVQLAGLRLLTNMTVTNDHQHMLHSYITDL-FQVLLTGNG
N-TK-VQVLKLLLNLSENPAMTEGLLRAQ---VDSSFLSLYDSHVAK----------EIL
LRVLTLFQNINNCLKIEGRLAV---------QPTFTE--GSLFFLLHGE--ECTQKIKAL
V-DHHDAEVKEKVLTIIPKI----------------------------------------
-------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MTGRRN--KARGQAKTEKK-A
KVQAKVGAEKEVTSA------VKPV---------------------AKTQSKTKAKTGYK
-----TDVV---------------------------------------------------
------AETKVV-------------SKNRVLDEMKEAALPEPKAPVKAI-----------
-----DDF----------------------------SSKAENGVTSSTCKDKAGIDTWFW
GGEE------------------------ASISSWFWKGEAAGN-HSSA------------
---------KDENK-------ADTGAHVCA----E-------------------------
------------ELKSEAGASCKSMSGVDE------------------------------
-EEDNVIGNWFWEGDETSFDP-EPKPVYRIVRPLP---VNEINQKNRPKDWSEVTIWPKA
PAVTP---AVLGFRSQVPAETKPSS----FIVVSSAEGSTHSFSA-------AAASPSRN
TCSSSQPIPESPFGSDLCV--------------------QTIDEIRQQIRIREMNGIKPF
ACPCKM------ECYLDSEEFEKLVSILKSTTDPLIHKIAQIAMGIHNVHPFAQ------
----------EFINEVGVVTLIESLLSFPSPER-------RKKTVITL-NP-LSVDERQR
KIELHVKHMCKETVSFPLNSPGQQTGLKILGQLTTDSVHHYIVASYFSEL-LNLLSEGNR
K-TR-NLVLKVLVNMSENPAAARDLINMK---ALSALKLIFNQKEAK----------ANL
VSAVAIFINIKEHIRKGSIVVVD----------HLSY--NTLT-AIFREVKGIIETM---
------------------------------------------------------------
-------------------------------------------

------------------------------------------------------------
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-----------------------MIGSKSKGKAREESGATLKPG--------NKSL----
------ANAKGKAKGQTKKVV-----EAEPKE-LR----NKAEARDEAVARRQTVTHTEP
--ETVTWKVKKK------------------------------------------------
------------------------------------------------------------
-----------KDKTNTRANAQAKTELLA-EPGLVPHTKSDASSMSVV--ITVTKSEVKV
D-----------------------------------------------------------
-------AGSEASVKCSAKAR-----DKGSMKHRSEV-----------------------
--------KKETCVRSG----------A--------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------GDKASIVI-----------------------------NATDEGEEYVCSWFW
TGEE------------------------PSVGSWFWPEDEYPLQV---------------
-----YQPPPK---------------------V-EEEP----------------------
------------------------------------------------------------
----------------------EPPED-----------------------TFDFTLKKKA
-AAW----ARG--RFIVLVPVE------------EG--EKT-LPP---------EGNWTL
VATLIET--------PLGIRPLTKIPPFEGPYIQTLAE------VKEQIREREKYGPNPK
ACRCKS-----RTFSLEPVEFDKLVALLRLTRDPFIHEIATMIMGISPAYPFTQ------
----------DIVHDVGITVMIENFVNNPNAKR------YP-KHINVN-VS-TDTSGEAK
EDEAHVNKVCRDILSCPLNCSVQVEELKLLASLSTKFEYHHVIVSYVRYF-ISLLNKGSV
K-IK-FQILRVILCLSKNQANTRELISAE---VLSSLVAHFHKNESK----------ANI
LHIIEIFENINFQFKKRAKLFTK--------DM-FTK--SELI-SIFHEAKEFDQKLQDL
A-DHSDPDVRDKVIRLILKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
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---------------------------------------MTGSKN--KARAQAKLEKR-A
SAQARAVAEREAANA------NRGA---------------------GKSRDKGKGKAGSK
-----SDAV---------------------------------------------------
------AEVKAG-------------SKGKVVAETKEGARPESKALVKGT-----------
-----SDF----------------------------NHRTENKFARSTRKDKPSSDNWFW
AGED------------------------SGINSWFWKGEELSN-NSVA------------
---------KCENK-------PSTSIQARA----E-------------------------
------------E--PAPRTSHKSRSGAEE------------------------------
EEEENVIGNWFWEGDDTGFDT-DPKPVFKIVKPQP---VDEINEKDRPKDWSEVTIWPKA
PAVTP---AVLGYRSQDSSEARSSS----YIVLASNEEETST------------A-CTKN
TRSSLQSIPEYPFGSDPCI--------------------QTLDEIRQQIKIREENGIKPF
ACPCKL------ECYLDSPEFEKLVNILKSTTDPLIHKIAQIAMGIHKVHPFAQ------
----------EFINEVGVVTLIESLLSFSSPEV------SIKKAVITL-N--SSGDDRYN
KVEFHVKHMCKETVSFPLNSPGQQSGLKIIGQLTTESVHHYIVVSYFSEL-FHLLSQGNR
K-TR-NLVLKVFLNMSENPKAARDMINMK---ALAALKLIFNQKEAK----------ANL
VSAVAIFINIKEHIRKGSIVVVD----------HLSY--NTLT-AIFREVKGIIERM---
------------------------------------------------------------
-------------------------------------------

------------------------------------------------------------
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---------------------------------MGGVRDVGWVAAG----------LVLG
AGACYCIYRLT--RGQRR-GGR---------KPRLRP--SR-------------------
------------------------------------------SAVPL-------------
------------------------------------------------------------
--E----------------K--------EMPX----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------XX-X----XXXX----------------------------X
XX---------------XXXXX------------XXXXXX--------------------
-----------XXXXX-------------------------------------X---DLT
DGSYD--------DVLNAEQLKKLLYLLEATEDPLIIEKALVTLGNNAAFSANQ------
----------XXXXXXXXXXXXXXXXXXXXXXX------XX-XXXXXXXXX-XXXXXXXX
XXXIYISQVCEDVFSDPLDSAVQMAGLRLLTNMTVTNDHQHMLKNHITEF-FHVLLTGNG
N-TK-VQVLKLLLNLSENSDMAEGLFSAQ---VDSSFLSLYDDQVAK----------EIL
LRVLTLFWNLNNCVLIL--------------LPP-FK--GSLFFLLYGP--ECTQKMEAL
R-HHPDADVKEKVVIVTFQ-----------------------------------------
-------------------------------------------

------------------------------------------------------------
--------------------------------------------MGRFQEVGWATAGLVI
WAGTCYYIYRLTKGRTQSVRRLTRNGSRV-KLETVVG----VQNQTLAMSEAMTGAEFET
KLKAKAGTEIGARGGARAEVETKTTAIAKPKANSQ----AKAMAEEEAQ--TE-------
TKAMAGIVVKTEAVTLVEVK--AKTREVAKKQAVTQTEAEAEKVVKKEAVTHAK-AKACS
LAARAEAKKEPMTQIKAEANRSAEKGTEFNRVVMTQTEVLSVTRE----VAKMGSMKKPG
VVAQTKARALEETVSVTKTQSEARPGATVDTRGNPNVMSRAAAGMDIGSCAQSQSVAKSQ
VEDMGGAGVEAKGNYK---------------------------TMSRVGSGADMKASAQP
QIVAKSQADSLPGARVDAG--GNVMCKAGAGPDMKTCT-QPPTMAKKQAEATPGTR-VDG
SGNPNATSRTMTGTDMRAAAQPQPIASAQTDARPDARLKARGMPNATSKAGARENLRFNA
QTEVLLEAKVKARGNPSAVSKAGVGTEMMSSK-KPQPVANAQVDALPDGRIKVRDNTNAM
LKEGPGTDLKAQCQAMVKSQVETLSSARGKGKSKASAKGRAGVGADMKASGQPQAGAKTK
DEDGPDPRVDGKDNLNAISRSEAKAGLMDCAQRHAVVSSQAEALPGGRNKTRGKPNAVSK
TGAGAHTKDFVQPQTTVSSKAEVLSGGSSKARDSPNVSKIEGRADTRNSVQPHAVVSSQD
EALPGGSNKVRSNPNDVSKSGTVADRKDSVFPQTAVSSQAENLPGNKNKIWGNANVGSKP
GARADTRDSIQLHAVVSSQSEDLPGGISKTRGNSSAVSKPEAGVDAKDSVQPHIVVNCQA
KTLPGSRNLARNNPKAASKTEAEVDTRDSVQPYAMVSSQSEDLPGGSSKARGNPSAVSKS
EAGVGTKD-SVQPQTVVNSQVKVLLGGSSKARGNPNAMSKTGAGADAKDSVQPQTVVNSQ
AKALPGGSSKDRGNPNAASKTGAGADAKD----------SVQPQAVVNSQAIALPGGSSK
ARGNPSTLSKPGVMAHAKDSDQSQTAVSSQAEALPGGSSKARGNPSTLSKPGVMAHAKDS
DQSQTAVSSQAEALPGGSSKARGNLNAASETGGGAGTRDSVQPQTVLTSQATVLPGGNNK
AKGNPNAGSKPGVMADAKDSDQSQTNVSSQAEALPGVSNDARGNLNFVFKPGAGADIRDS
VQPQTVLTSCAEALPGGSSKARGNPSTVSKPE-----ARVDAKDSVQPQTVVNSQAEALP
GGSNEARGNPNAISKPGTGAGTRNCVQPQTVVSSQVEALPGDSNKVRGN--PNVVSKT-V
GADTRDSLQPHTAVNSQSEALHGTRNKVRGNLNAVSKAVTGVDLRDSAQPQVVASSQAAS
LSGARSKVRGSPNTMSNGGTGADTKDFVQCHTEDNFQGESLPGARGKAMPRSDAEATADV
EVSAKP----ETISSSEIEGGVGIQTYKETQGKVHHYYWNGIGIEDWIAAERWIKFRFQA
RDGYWENSMSWAEGEDEDNIGSG----------------TVAH----DKARIKSWSEARA
GNEAGIGSWAVAG-HQANGGSWPQVQASERSWSGEEVSREYWTEVEKQARVGTWAGAEEQ
AKRRSWDGSGIHA-----------------------------------------------
---------------------------SGRSWAGTRAENVASFVYWAGAVDQASE-RPWV
GT------------EDQSCVGSKLRFEDQASGGV---------------GG--------Q
AGAGGQVCEGSRLGPMDQSSSRPWSATGNQASGGSLNGVGNQASEGSWAGPGDQ------
------------------AGDGSKLRCEDQVSGEVVGQAGAGGQANEVFRLEHTDQSSGG
SCDDTEDKASEGSRLGPVDQSSGESWAGA----MHQVSGR-------------KSCVDTG
DQSSGGCRLGPADQSCNRTWAATGNQTSGGSLVGSGDEAGGDSRAGNEDQSCVGSKPRYE
DQVSASGEV-GGHAGATGQDDGGPFLGPMGQSRGG------DQTSGRSSLG---------
---------------------------------PVGQSGGESWAGDQV-SGGGSWVDTGD
RVSGGSRLGSVDQSS---------------------GRTCADIGNQASGGSFVRAE---D
QADRGSWVEAR--DQ-TGVGSNPRFEDQ-ASGGVDGQ-VGDGSRADS-------------
---------------R---------------------------------------SLLGP
IDQSRGGSCADTGDQISGWFYTCTGSQASGEVSWAGVGGQTVGGSRVGPTGQSYCGSWAH
TGSQVSGESWTGTGDHNGDSSKPGLEDQASGG----------------------------
-GSRLRSEDQC--------SRESWAGTGNQSGGECGPGPVDQSH--GGSWAGTGNQ----
-----------------------------------------------------------A
NEGTWSGAGNEASGCSKP----------------------------------GF------
KEQ---VNGEASWVGSRSGNEAS-------------------------------------
------------------------------------------------------------
---------------------GQSGDRTGDQPSGKYLSEAGDQAS--GVSWTRAEDQANR
GSQ--VRAGEEASQGSWFETG-----DDSNIESWFWAGEEAN----NVSRPTGKD--E-V
SIESRSGAREEAIISSR----------FETED----------------------------
------------------------------------------------------------
----------------------------------------------KVSNGSWIRS----
--EEATYMGSCAGAE---------------------------------FGAKAKMRSWFW
DGDA------------------------TTIGSNLGAREKARI-----------------
---GFWAMTGN------I-EEDELSTRSSP-DI-EEIS----------------------
-LRSLFWAESEDSTEFRSK--------SKKD--VNFECGSKDKV-SIRDKLEA-------
-ADEVSIRSWLSVNNENRSEG-KPGPIAKAKKSLE-S----------ISTYPCM-VPGAG
MGSW----AGAMIWTETA--LP------------YR--KESCFPPEE----E-----LR-
KQ-I-----------------------------------RA------------GEKIRPW
ACRCKR------EAKMNPQELEKLICMIEMTEDPSIHEIANNALYNSSDNPYSQ------
---------EEAIRNIGGISIIESLLNNPYPSV------RQ-RALNALNNI-SVAAENHR
KVKTYLNQVCEDTVTYPLNSSVQLAGLRLIKHLTITSEYQHMVTNYISEF-LRLLTVGSG
E-TK-EHILKMLVNFSKNPSMTKDLLIAN---APPTLINIFSKKETK----------ENI
LNALSLFGNINYHFKKRAKILTQ--------DK-FGK--NSLY-FLFQRPRVWAKKLRVL
LAEYNDPEVKERVELLISKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
--------------------------------MTYYTRKVGRVTAG----------LLLG
AG----------------------------GGSGDMD--DAG----------------DC
---------------------------------------------------------SGA
--RYNDWSDDD----------------------------------------------NDD
DDS----------------N--------E-------------------------------
------------------------------------------------------------
-SRTIVWYPPWAR-----------------------------------------------
------------------------------------IG----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------T--------------------------------
-----------EAGTRARARA---------------------------------------
------------------------------------------------------------
-------------RARAN---------------------------RA----RQAVQKRAS
PNSND--------TVLSPQELQKVLCLVEMSEKPYILEAALIALGNNAAYAFNR------
----------DIIRDLGGLPVVAKILNTRDPIV------KE-KALIVLNNL-SVNTENQR
RLQIYMSQVCDDTVTSRLNSSVQLAGLRLLTNMTVTNEYQHILANSISDF-FRLFSAGNE
E-TK-LQVLKLLLNLAENPAMPRELLRAQ---VPASLGSLFDKKENQ----------EVI
LKLLIIFEHINNNFKWEENEPT---------QNQFGE--GSLFF-FLKEFQVCADKVLGI
E-SHHDFLVKAEVEKFMAKLAEHMFPKNQE------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
---------------------------------MGGARDVGWVAAG----------LVLG
AGACYCIYRLT--RGPRR-GGR-----------RLRP--SR-------------------
------------------------------------------SAE---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------DLT
DGSYD--------DILNAEQLKKLLYLLESTDDPVITEKALVTLGNNAAFSTNQVXXXXL
RGSSMGGAQDAIIRELGGIPIVGNKINSLNQSI------KE-KALNALNNL-SVNVENQT
KIKIYVPQVCEDVFADPLNSAVQLAGLRLLTNMTVTNDYQHLLSGSVAGL-FHLLLLGNG
S-TK-VQVLKLLLNLSENPAMTEGLLRVQ---VSNYLPGSLVH-----------------
-----------SCRDSDK------------------------------------------
------------------------------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
-------MTGAEIEPAAQAKPEKKAGEEVG--------G-----------GAERENEVPL
VVRPKV--------------------------RTQAQAMPGARPKTETKSMPGARPKIES
------QAVAGA------------------------------------------------
--------------------------------------------RPKAE------ARAVG
GARPKT--EAKAIPGARPKDEA--------------Q--------------AWAQTEFG-
-----AEAMSQTEGLTQTNAVAWPLINTES--GSVAKPMAVSVDRELVSVDTETFPGSQ-
-VQTGIQPWFGSG-EEAN------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---MGSWCYPRPRAR-EEASNESGFWSADETSTMSSFWAGEEASIRSWPREEA---STRS
RHRAKHQ-----P--NPRSRPRTKQDPYIDS-WSGSE-----------------------
-EESGNPFCLWAGENNNNLF----------------------------------------
---------------------RPRVKDEANIRSKLRAKRGDF--FESESE------DEYY
KESWFLPGEEA---------NSR-----FRTRDKEEPNTVLKPR----------------
AQ----KDVNNSGRVKQEPRY-----EEDIIIGSWFWAEKEA------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------GM
EAR------ASAICESTPGAE-----EGAI------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------GGSLFWTEEKS
SLRA--------------------------------------------------------
-----------------------------------------------VAREEARPES---
------------------------------------------------------------
------------------------------------------------------------
-EEEAIFGSWFWDRDEACFDL-NPSPVYKAKSRFRDSAEDELKASSRPQTWEEVTVEFKP
-SLC----HGIGFPSPSSFRIPEEA-ASVFSEMFEAKPKNAEFTPEG----E--DPESLL
QSEQ--PEPEFRFQYDPSY--------------------RSVREIREHLKARDSAEPESW
SCSCIQ-----CELKIGTEEFEELLLLMDRIRDPFIHEISKIAMGMRSASQFTR------
----------DFIRDSGVVSLIETLLNYPSSRV------RT-SFLEDMIHM-APPYPNLN
MIETFICQVCEETLAHSVGSPEQLLGLRMLRHLTITTDYHTLVANYMSGF-LSLLTTGNA
G-TK-FHVLKMLLNLSENPIVAKKLFSAK---ALSIFVGLFNIEETN----------DNI
QIVIKMFQNISNIIKNGTMSLID---------DDFNL--EPLV-SAFHEFEKLAKELQVQ
IDNQNDSEVGQQS-----------------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
-------MTGAEIEPSAQAKPEKKAGEEA---------------------GAERENEVPL
VVRPKV--------------------------RTQTQVTSGARPKTKTKVMPGVKPKT--
------------------------------------------------------------
------------------------------------------------E------ASAMR
RSRRKN--KAKAIPGSRFKDEP--------------Q--------------VYAQT----
--------------------SSSPLVSTDS--KLVAKTNSLSVDRELVSMDTDNFQGRKA
DSQAGFQPSLMSE-DETY------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---MGSWHSNRPTSK-QEASYNSNFRGVDKSSMSSWFWSGDEVTTRGHPRNQTKA-STRS
RHMAKHE-----A--NTMSRPQTNQELYIVS-SSGSE-----------------------
-DESAKSSWFWSREKTNTSS--GLRGGD-SSRSRFRFKKEVYV------------ESSSG
SENEGHMKSWFCAGEEAKFRSKRRARKEANIRARRRGRREACVDFMSGSI------DVIK
KESCFWPEEKI---------NTF-----SRPKTKKEARARAIAK----------------
AE----AKSKARARARQEARS-----EEEVLIGTWFWATEEPSMVDGASVKSSPQVEDES
IVGSWFWPEEEASAGTGASSLS-RPIV-EESISDLWLTTG-EKTSMKTGIEAISESILAA
DDE-EVIIGSWFWAGEE-VS---------------------------------PEAEEET
IFGSWFWIIDETS-VESAVGVSCE-------------------------------SRLN-
-SEEEEVIGPWFWAEEEIDTETGVREQ----------ARPGAEEETIFGSWFWAENQTHM
DSG------AEPSCDTTPGAD----EEEPIIESWFQARVE----ADVNSKSGMEDEEE-D
IIPFWFRAREEVSMMYGADARCTFMAGAEETKNRSCFWEEEEPCMYSASGGSWKSSSEEE
-----EDTVDSWFWSKKYTRPEAIVG------------------------SQLWAAEEGS
I-DGTGEEAKLPAEDEIMINSWFWKED-EAIIEATNREESRSEAEEEDIIGSWFWAGEED
RFQAEPEAGEENRLTVEEE-GIVGSWFWAREEAIRREDEFCSKSSHKAEEEEVTVRPWLW
EEEASLEAAAGTNFEFNPGTQEE----EITVGSWFWAEEAASIEAGSQAVEETGSGTEEE
TIFGSWFWA-----------EAETCCVSKSEND-EEMI----------------------
-VESWFWSEDKAIKETESVAAYESRSENEEEISIGYLFGAEDEMNNRTDNVTNYEYRASV
DEDEAIVGSWFWAGDEAHFES-NPKPVFRDICMPGCSVEQDPDPSRRPQTWEEVTVQFKP
-GPW----GRLGFPCISPFKFPKEA-ASLFCEMFGGKPKNMELGPEG----E--EQESSS
QTDQ--PDPEFPFQYEPSY--------------------RSVREIREHLRARASAEPENW
SCSCIQ-----CDLKIGSEEFEELLLLMEKTRDPFVHEISKIAMGMKSASQFTR------
----------DFIRDSGVVSLIETLLNYPSSRS------RT-RFLENMIHM-APPYPNLN
MIQTYICQVCEETLAYSLDSPEQLSGIRMISHFTTTSDYHTLVANYMSGF-LSLLATGNA
K-TR-FHVLKILLNLSENLVMTKELLSAE---TLSEFMGFFNREETP----------DNI
QIVLAIFENISKNIKKEE-EFA---------DDDFDL--EPLI-SAFYEVEKFAKELQGK
TDKQNDPEADQGN-----------------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------SAE---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------DLT
NGSYD--------DVLNVDQLQKLLYLLESTDDPVIIERALVTLGNNAAFSANQ------
----------VIIRELDGIPVIGSKINNPNPSI------KE-KALNALNNL-SVNVENQV
KIKVYMNQVCKDVLSGPLDSAVQLAGLRLLTNMTVTDDHQHVLSCYVPDL-LRVLLAGNA
A-RD-VQVLKLLVNLSENPAMAEGLLGAQ---VDSSFLSLYDGHVAK----------EIL
LRALTLSRNVTKCLGKEGSLAV---------QPTFPT--GSLFFLLYGE--DYAQKMRAL
A-EHCDADVKEKVTFIPKF-----------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
---------------------------------MGYARKVGWVTAG----------LVIG
AGACYCIYRLA--RGRRQSKEK-MA----EGGSADVD--DAG----------------DC
---------------------------------------------------------SGA
--RYNDWSDDD-------------------------------------------------
DDS----------------N--------D-------------------------------
------------------------------------------------------------
-SKSIVWYPPWAR-----------------------------------------------
------------------------------------IG----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------T--------------------------------
-----------EAGTRARARA---------------------------------------
------------------------------------------------------------
-------------RARAT---------------------------RA----RRAVQKRAS
PNSDD--------TVLSPQELQKVLCLVEMSEKPYILEAALIALGNNAAYAFNR------
----------DIIRDLGGLPIVAKILNTRDPIV------KE-KALIVLNNL-SVNAENQR
RLKIYMNQVCDDTITSRLNSSVQLAGLRLLTNMTVTNEYQHILANSISDF-FRLFLAGNE
E-TK-LQVLKLLLNLAENPAMTRELLRAQ---VPSALGSLFNKKENK----------EVI
LKLMIVLENINDNFKWEENEPA---------QNHFSG--GSLFF-FLKEFQVCADKVLGI
E-SHHDFLVKVKVGKFAAKLTERMFPKSQE------------------------------
-------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MGYARKVGWVTAG----------LVIG
AGACYCIYRLT--RGRKQNKEK-MA----EGGSGEVD--DAG----------------DC
---------------------------------------------------------SGA
--RYNDWSDDD-------------------------------------------------
DDS----------------N--------D-------------------------------
------------------------------------------------------------
-SKSIVWYPPWAR-----------------------------------------------
------------------------------------IG----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------T--------------------------------
-----------EAGTRARARA---------------------------------------
------------------------------------------------------------
-------------RARAT---------------------------RA----RRAVQKRAS
PNSDD--------TVLSPQELQKVLCLVEMSEKPYILEAALIALGNNAAYAFNR------
----------DIIRDLGGLPIVAKILNTRDPIV------KE-KALIVLNNL-SVNAENQR
RLKIYMNQVCDDTITSRLNSSVQLAGLRLLTNMTVTNEYQHILANSISDF-FRLFSAGNE
E-TK-LQVLKLLLNLAENPAMTRDLLRAQ---VPSSLGSLFIKKENK----------EVI
LKLLIIFENISENFKWEENEPV---------QNQFSD--GSLFS-FLREFQVCADKVLGI
E-SHHDFLVKVKVGKFMAKLTEDMFPKSQE------------------------------
-------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MGYARKVGWVTAG----------LVIG
AGACYCIYRLT--RGRKQNKEK-MA----EGGSGDVD--DAG----------------DC
---------------------------------------------------------SGA
--RYNDWSDDD-------------------------------------------------
DDS----------------N--------E-------------------------------
------------------------------------------------------------
-SKSIVWYPPWAR-----------------------------------------------
------------------------------------IG----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------T--------------------------------
-----------EAGTRARARA---------------------------------------
------------------------------------------------------------
-------------RARAT---------------------------RA----RRAVQKRAS
PNSDD--------TVLSPQELQK-------------------------------------
------------------------------------------------------------
-----------------------LAGLRLLTNMTVTNEYQHILANSISDF-FRLFSAGNE
E-TK-LQVLKLLLNLAENPAMTRELLRAQ---VPSSLGSLFNKKEYK----------EVI
LKLLIIFENINDNFKWEENEPA---------QNHFSE--GSLFF-FLKEFQVCADKVLGI
E-SRHDFQVRVKVGKFVAKLTERMFPKSQE------------------------------
-------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-----------------------------------------------MGRARE--VGWMA
AGLM----IGAGACYCVYKLTI------------GR--DDSEKSEE------E-EEEWDD
ERELDDEEREIWFDLTTMARPWSEDGDWTEPGAPGGAEDRPSGGGKASRT--YLVKQRPF
PYEHK--------NTWSAQSFKNFCCALGLSKGPFIQGKMLLAEPKDASFSFSH------
----------DINSHLASLSIDGNTIPTPDPAV------EEGKALYVPDNL-NASVENQG
QMKTCISQVCRETVSLCCNSFLQQAGLNLLISMTVIKN---MLAKSVPGLMLPLIPEGSE
C-AE-GQVVKPLTGLSEKPALSGELLRAQ---VLWPFLPLFIRNTNR----------QLL
SETLAS------------------------------------------------------
------------------------------------------------------------
-------------------------------------------

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--------------DTDLRHI--EHQIQGWTYTFNRALTMAK--N--RRRNKSKAAKK-A
-VQAE--VEKAATNV------VKPG---------------------DKNQAKSVAKAGSQ
-----AAAV---------------------------------------------------
------AESKAV-------------SKKKTIAEKKKGAMTDSSPKTEAS-----------
-------------------------------------AE-----SKSKCNNKIGIDACLW
AEEG------------------------TSVSSQPGN-AEGGN-SSTV------------
---------KNEVKD------KDTGSAPCV----G-------------------------
------------KSEPVSGASSKAKPAPKEE-----------------------------
EEEYDVIGSWFWDGDETSFDP-NPRPVSRIIKPQP---VDEINEKDRPRDWSEVTIWPKA
PAITP---AVLGYRSQTPSEPKPPS----FIVLASADDNTSSKSG-------AEACSSSE
IPTCTQ--AEYPFGSEPCV--------------------QTIEEIRRQIKIREMNGIKPF
ACPCKM------ECYMDSEEFERLISLLKSTTDPLIHKIAQIAMGIIDVHPFAQ------
----------EFINEVGVVTLIESLLSFPSSEM-------RKKAVITL-NP-PSGDERLR
KAELHVKHMCQETMSFPLNSPGQQSGLKILGQLTINANHHHIVLGYFPGF-FNLLSQGNR
K-TR-NLVLKVLLNLSESPVAARDMTGTE---ALAALKLIFNQKEAK----------ANL
VSAVAIFINIKEHIRKGSIVVVD----------HESY--NSLM-AIFREVKGIIETM---
------------------------------------------------------------
-------------------------------------------

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---------------------------------MGYARKVGWVTAG----------LVIG
AGACYCIYRLT--RGRKQNKEK-MA----EGGSGDMD--DTG----------------DC
---------------------------------------------------------SGG
--RYNDWSDDD-------------------------------------------------
DDN----------------N--------E-------------------------------
------------------------------------------------------------
-NKGVVWYPPWAR-----------------------------------------------
------------------------------------IG----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------T--------------------------------
-----------A------------------------------------------------
------------------------------------------------------------
-----------------T---------------------------RA----RRAVQKRAS
PNSDD--------TILSPLELQKVLCLVEMSEKPYILEAALIALGNNAAYAFNR------
----------DIIRDLGGLPIVAKILNTRDPIV------KE-KALIVLNNL-SVNAENQR
RLKIYMNQVCDDTVTSRLNSSVQLAGLRLLTNMTVTNEHQHMLANSISDF-FRLFSAGNE
E-TK-LQVLKLLLNLAENPAMTRELLRAQ---VPSSLGSLFNKKENK----------DII
LKLLIIFENISDNFKWEENEPT---------QNHFGE--GSLFF-FFKEFQVCADKVLGI
E-SHHDFLVKVKIGKFMAKLAEHMFPKSQE------------------------------
-------------------------------------------

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-------------MICRLDSAVQMAGLRLLTNMTVTNHYQHLLSYSFPDF-FALLFLGNH
F-TK-IQTMKLIINFTENPAMTRELVSCK---VPSELISLFNKEWDR----------EIL
LNILTLFENINDNIKSEGLASS---------RKEFSR--SSLFF-LFKESGVCVKKIKAL
A-NHKDLVVKVKVLKVLTKL----------------------------------------
-------------------------------------------

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---------------------------------MGGARGVGWVAAG----------LLLG
AGACYCIYRLT--RRRRR-GDR---------GLVLRP--SQ-------------------
------------------------------------------SAG---------------
------------------------------------------------------------
---------------------------------SLE---EG-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------TP-------------------------------
------------------EGQ-L----CGQ------------------------------
------------------------------------------------------------
---------------------------------------------------------DLT
DGSYD--------DVLNAEQLQKLLYLLESTEDPIIIEKALITLGNNAAFSVNQ------
----------AIIRELGGIPIVGNKINHSNQSI------KE-KALNALNNL-SVNVENQI
KIKIYINQVCEDVFSGPLNSAVQLAGLRLLTNMTVTNDHQHMLHSYITDL-FQVLLTGNG
N-TK-VQVLKLLLNLSENPAMTEGLLHAQ---VDASFLSLYDSHVAK----------EIL
LRVLTLFQNINNCLKIEGHLAV---------QPTFTE--GSLFFLLYGE--ECAQKIRAL
V-DHDDAEVKEKVVTIMPKI----------------------------------------
-------------------------------------------

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---------------------------------------MTGAKN--KSRTQAKTEKK-A
CVQAKAATEKEATPV------VRPV---------------------AKTRVKAKAKSASK
-----SESV---------------------------------------------------
------TDTKAV-------------PKNKVVAEVKGRALSEPKTLVKAM-----------
-----ADL----------------------------SPKVENEATSSTCKNEICIDSWFW
CGEE------------------------ASINSWFWTGEEASN-CSSA------------
---------KNEGKD-------NSVAQVCA----K-------------------------
------------ELEPVAGASHKSRSGAEE------------------------------
EEEENVIGNWFWEGDDTSFDL-DPKPVYRIVRPQP---VDEINEKNRPKDWSEVTIWPNA
PAVIP---AVLGYRSQVSCETKPPS----YLVLASAEENAHSLPA-------STACSSRN
TRSLSQPIPECPFGSDPCI--------------------QTIDDIRRQIRIRELNGIKPF
ACPCKM------ECYLDSEEFEKLVNLLKSTTDPLIHKIAQIAMGIHNVHPFAQ------
----------EFINEVGIVTLIESLLSFPSLDV-------RKKTVITL-NP-PSGDERQH
KVGLHVKHMCKETVSFPLNSPGQQSGLKILGQLTAQSVHHYIVASYFSEL-FHLISVGNC
K-TR-NLVLKVLLNMSENPTAARDMIDMK---ALAALKLIFNQKEAK----------ANL
ISAVAIFINIKEHIRKGSIVVVD----------HLNY--NALM-AIFRDVKGIIKSM---
------------------------------------------------------------
-------------------------------------------

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-----------------------------------------------MGRARE--MGWMA
AGLM----IGAGACYCMYKLTM------------GR--HGSNQLED------EEEDEWDD
EQNLDEEEADNWFDFTTMARPWSEDGVWDEPGAPGGTEDRRSGGGKANRA--HPSKQRPF
PYEHK--------NTWGAQSFKSFDCALDLTKCASIQGKKMFTQPTNAVFSLSH------
----------NVSSHLASLSVVGNGIPTRQPTA------RE-KALCVPENP-NTSIGNEG
QIKMYIGEVCRETVLGGCKSFLQQAGLDLLISMTVINN---LLAKSVSDLKFPLISQGRE
C-AK-VEGLGALVGLPEKPVLAGEVLAAQ---LLSSSMLPFIRSRSR----------EML
LEALSP------------------------------------------------------
------------------------------------------------------------
-------------------------------------------

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------------------------------------------------------------
---------------------------------MGGARDVGWVAAG----------LVLA
AGACYCFYKLT--RGRRR-GGR---------QLRLRP--SR-------------------
------------------------------------------SAE---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------DLT
SGSYD--------DTLNAEQVQKLLYLLESTEDPVIIERALVTLGNNAAFSANQ------
----------IVIRELGGIPIVGSKINNPNQSI------KE-KALNALNNL-SVNVENQI
KIKVYVSQVCEDVIAGPLNSAVQLAGLRLLTNMTVTNDHQDMLSSYITDL-FHVLVTGNG
S-TK-VQVLKLLLNLSENPAMTDRLLDAQ---VDSSFLSLLDGHVPK----------EIL
LRALTLLQNITNCLNEEHRLAA---------QPTFPE--GSLFSLLYGK--ECAQKMKAL
V-HHHDADVKEKVTM-IPKF----------------------------------------
-------------------------------------------

------------------------------------------------------------
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---------------------------------MSRARDAGCVAAG----------IVIG
ASAWYCVYKYT--RGKDQ-KKKRLT----KPKNRA--SVGTGSRARAGLRAGFTIDLGPG
FSPPNPVDIEIMNK-AQGEASNLATTVAEEVAPAA------PSPKVQNGAESKVQELNGA
--KT-EANLESVVMPSATCTVTPPPKVAGGL------------TAAEAPEIIGAPKVLEA
PST----------------T--------EASGAVAA-PGPTVSPMIAQTPGPVVPS----
-----------------PTIVSTG--------------PAAI------------------
---------PWAVA----------------------------------------HPGAVQ
SPGPA----------VPPMAV---QSLVPAAPSWAVVAP---------------------
-----------------PGAVYIPVAAHF-----------AGPAAAS----RVTQSPGTV
IPPLPPPSSV-------LPRGVPSVPGRTVQSPGAAVHPVAAQSTGVVVPPRAVQYSGAA
VTSGGA-----AVPSGG---------AAT------------PRAAASTQRTASTEVMQVP
RVAAATEATETPRIGTP------------------------------AMVAEASLP----
----V-----------HSGAA-----------------E-NP------------------
----------------------GTSGSSK-------------------------------
-----------TAA-----TGKKAAPGAHTGAIPKAGS--ATGA---VPKGGG-------
-------G---KGGNKNRSGG-K----GKNR-------------K-NKVDVDELGMGFRP
GD---------GAAAAAAASAN------------GGQAFLAEIPES-----EEGESGWTD
TESDSDSEPDVPQRGKG----------------------------KR----TIPMHKRPF
PYEID--------EILGVRDLRKVLALLQKSDDPFIQQVALLTLSNNANYSCNQ------
----------ETIRKLGGLPIIANMINKTDPHI------KE-KALMAMNNL-SENYENQG
RLQVYMNKVMDDIMASNLNSAVQVVGLKFLTNMTITNDYQHLLVNSIANF-FRLLSQGGG
K-IK-VEILKILSNFAENPDMLKKLLGTQ---VPSSFSSLYNSYVES----------EIL
INALTLFEIIFDNLRAEVFN-----------YREFNK--GSLFY-LCTTSGVCVKKIRAL
A-NHHDLLVKVKVIKLVNKF----------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
-------MTGAEIEPGAQSKSEKXXXXXXX-------XX-----------XXXXXXXXXX
XXXXXX--------------------------XXXXXXXXXXXXXXXXXXXXXXXXXXXX
------XXXXXX------------XXX------------------------------X-X
XXXXXXXX----------------------------XXXXXXXXXXXXX------XXXXX
XXXXXX--XXXXXXXXXXX--------------------------------XXXXXXXX-
-----XXXXXXXXXXXXXXXXXXXXXXXXXXTEYGSAKNALSMDRELDSVEAESFHGPKI
QSQAGIQPWFGSG-EETN------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---MGSWCYPRPRAQ-QEATNESGFWSADETLAV-SFWAGEEASVRSWPKEEA---HTRS
QHRAKQQ-----N--NTRSRPKIKQEPYID-----SE-----------------------
-DEAGDPYCLWAGENTNTLS----------------------------------------
---------------------RPRAREEANIRSKLRTKREDC--FESGSE------DEFY
KESWFLSGEEA----------NR-----CRSRDKEEPNTNRKSR----------------
AP----KDNNNQDRVKQEPRC-----EEEVVIGSWFWAEKEA------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------SM
EDG------AVAICDSGSGAE-----EGSA------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------ARSLLWMEEET
SSGA--------------------------------------------------------
-----------------------------------------------EAREDTRPES---
------------------------------------------------------------
------------------------------------------------------------
-EEETLFGTWFWDRDEACFDL-NPTPVYRARCKFRNLAEQDINVSSRPQSWEEVTVEFKP
-GLC----HVVGFPSTSSFRFPEET-GPVFSEMLGEEPKNVELSPEG----E--EQESLL
QSDQ--PDLEYPFQYDPSY--------------------RSVREIREHLKAKESAEPESW
SCSCIQ-----CELRIGSEEFEELLLLMDKIRDPFIHEISKIAMGMRSASQFTR------
----------DFIRDSGVVSLIETLLNYPSSRV------RT-SFLENMITM-APPYPNLN
MIETFICQVCEETFVHGLDSPEQLLGLRMVRHFTTTTDYHTLVANYISEF-LSLLTTGNR
R-TK-FHVLKMLLNLSENPVMAKNLFSAK---ALPVFMGLFNIEESN----------DNI
QIIIKIFQNISNNVKKGVMFLID---------DDVSL--EPLI-SAHREFEKLAKELQVQ
IDNQN-------------------------------------------------------
-------------------------------------------

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------------------------------------------------------------
--------------------SGKTKPAAEE------------------------------
EEEENVIGNWFWDGDETSFDP-NPRPVSRIIRPQP---VDEINEKDRPKDWSEVTIWPKA
PAVTP---AVLGFRSQASSETKPPS----YIVLASAEESTHSLPAA-----T--ACSSRS
TPSGTQPVPEYAFGSDPCI--------------------QTIEEIRRQIRIREVNGIKPF
ACPCKM------ECYMDSEEFEKLVTLLKSTTDPLIHKIAQIAMGIINVHPFAQ------
----------EFINEVGVVTLIESLLSFPSSEM-------RKKAVITL-NP-PSGDERQR
KVELHVKHMCKETMSFPLNSPGQQSGLKILGQLTTDSNHHHIVASYFSEL-FHLLSLGNR
K-TR-NLVLKVLLNMSENPTAARDMINTE---ALAALKLIFNQKEAK----------ANL
VSAVAIFINIKEHIRKGSIVVVD----------HLSY--NTLM-AIFREVKVIIETM---
------------------------------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
-------------------------------------------------------KGEHF
----Y--------LKSDAKDIKNFCCALGFSKGPFMQGKVLLAEPKDAGFSFSH------
----------DINSHLASLSIAGNTIPTPDPAV------EDGKALCGPDNL-NAGVENQG
QMKTCLSQVCRETVSLCCNSFLQQAGLNLLISMTVINN---MLAKSVSGLMLPLIPEGSE
C-AE-GQVVKPLTGLSEKPALSGELLRAQ---VLCPFVPLFVRNTNR----------QLL
SETLAS------------------------------------------------------
------------------------------------------------------------
-------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MGYARKVGWVTAG----------LVIG
AGACYCIYRLT--RGRKQNKEK-MA----EGGSGDVD--DVG----------------DC
---------------------------------------------------------PGA
--RYNDWSDDD-------------------------------------------------
DDN----------------S--------E-------------------------------
------------------------------------------------------------
-NKGIVWYPPWAR-----------------------------------------------
------------------------------------IG----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------T--------------------------------
-----------EAGTRARARA---------------------------------------
------------------------------------------------------------
-------------RARAT---------------------------RA----RRAVQKRAS
PNSDD--------TILSPQELQKVLCLVEMSEKPYILEAALIALGNNAAYAFNR------
----------DIIRDLGGLPIVAKILNTRDPIV------KE-KALIVLNNL-SVNAENQR
RLKIYMNQVCDDTITSRLNSSVQLAGLRLLTNMTVTNEYQHMLANSVSDF-FRLFSAGNE
E-TK-FQVLKLLLNLAENPAMVRELLRAQ---V---------------------------
--LLVIFENINDNFKWEENEPT---------QNQFSE--GSLFF-FLKEFQVCADKILGI
E-SHHDFLVKVKVGKFMAKLAERMFPKSQE------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------MICRLDSAVQMAGLRLLTNMTVTNHYQHLLSYSFPDF-FALLFLGNH
F-TK-IQIMKLIINFTENPAMTRELVSCK---VPSELISLFNKEWDR----------EIL
LNILTLFENINDNIKSEGLASS---------RKEFSR--SSLFF-LFKESGVCVKKIKAL
A-NHNDLVVKVKVLKVLTKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MGRTREAGCVAAG----------VVIG
AGACYCVYRLA--WGRDE-NEKIWD----EDEESTDT--SE-------------------
-----------------------------TGVETV------KGAKTNVGAGSGAKLQGDS
-----------------------------KV------------KPEVSLGLEDCPGVKEK
AHS----------------G--------SHSGGGLE---AKA------------------
-----------------KALFNT-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------L----------------------------------
----------------KEQASAKAGKGARVGTIS--------------------------
---------------------------------------------GNRTLAPSLPCPGGR
GG---------GCHPTRSGSRA---------------------------------GSRAS
GKSKGKARSKSTRAPA-T---------------------------TW----PVRRGKFNF
PYKID--------DILSAPDLQKVLNILERTNDPFIQEVALVTLGNNAAYSFNQ------
----------NAIRELGGVPIIAKLIKTKDPII------RE-KTYNALNNL-SVNAENQG
KIKTYISQVCDDTMVCRLDSAVQMAGLRLLTNMTVTNHYQHLLSYSFPDF-FALLFLGNH
F-TK-IQTMKLIINFTENPAMTRELVSCK---VPSELISLFNKEWDR----------EIL
LNILTLFENINDNIKNEGLASS---------RKEFSR--SSLFF-LFKESGVCVKKIKAL
A-NHNDLVVKVKVLKVLTKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
--------------------------------------------MGRTQEVGWVTAGLVI
WAGTCYYIYKFTKGRAQSVRTLARNGSTV-KMETVVG----VQSQTLAISEAE----IKT
KPQAETGAETGTRGGPGAEVETKATAIARHRANSQ----AKTMVEAEAETQSE-------
SKVVAGTLVMTEAVTLTEVK--AKAREVAMKEAVTQTDAEAGKIVKKEAVTQTK-AKAWA
LVAKTEAKREAMTQTKAETHILAEKETEINRVMVTQSETLAVPSE----VVKMGATNKTG
IVDETKTRALEETVSVAKTQSEARPGATVDARGNPNGMSREVAGVDMKSCAQSQAVTKIK
GDDMPGAGIEDMGNCK---------------------------TMSRAESGADMRASAQP
QIVAKTQTEAIPAAKVDAGSNTNAMCKVGAGADVRACK---------QDEVTSCAR-VDG
RGNTNVISKVITGADMRAAAQPQAVASAHAEAMSDAKVKDRGNPNAMTKAGARANLRANS
QVEALPDARDKSRGNPNVIAKVGDGTDMLSCT-QPQLVASVQANALSDGRIKVKGNVNTM
PKEGAGVDMKAQ--GMAQSQGEALPNTRGKARGKAK------------------TGVKTP
AEALLDS------------------------RPLVVANPQGEALLGAKNKVKGNPHAVLK
VGAGEGTADSAQPQAV---------------------------------------VSFQG
EALLGTKNKVKGNPNVVLKAEVGAGAMGTAQLQIEASSKGEALLDSKNKVKGNSNAVSKA
RAGTDTTGSVQPQIVANSQGEVLPGAKNKVRGNSTTVPNSGVGPYT--------------
--------------------------TDSAQPQAVANSQGEVLPGAKNKVKANLNALSKA
EAGMGAT-----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------GSVQSQAVANAHCETLPGAKNK
VKGNWNAVSKAGAGMDTRGSAQTQAVANSQGEVLPGARNKVKGNPNVVSKAGAREDTMGS
AQPQVVAN---------------------------------------------SQRETLP
GARNKAKGNSNAISKAEAGAGIMGSVQVQVVASSQGEVLPGAKNKVRGN--SNAVPKAEA
GADTVGSAQPQAVANSQSETLLGARNKVKGSTNTVPKAGTGAGTRHSAQPQIVAGSQ---
-------------------------------------GETLPGARDKAMPSSEAETTAED
EVYAKPE--AEAMPISESEGGSGTQACRKTQPNIHDYYWNGIGVEDWIAAERWIKFRFQT
MDGDWENSVSWADDENEASIGSWSGV-SDK--AGIIRSWAVAC----DEASVKSWAGARA
ENEVGIGTWARAG-EQASGGLWAGGQTSEGTWAGD------------KASGGAWTGAENQ
ASGGSWALAGSQAIGELWAAGQASNGSWPGGQASGVSWVGEEAIGGSWTG--------AE
NQASGGSWAGA------------------------GAGNMSSVSYWAGVVDQASG-GSWA
GT------------SDQSGGGSKPRFEDQASGEGSWAGAGDQASGGSRLGPEDQSSGRSW
ADTADQASGGSRLGHVDQSSGG--------------------------------------
----------SWAGTLDQSGGGSKPRFENQTTEEG-SWAGAGGQAGGGSKVGSEDQSSGR
SWANSGDQISGGFLVGVVDQANGGSWTGA----GHPASGGPKPIFEDQASGRGSWA-DAG
DQVVGDSRLGLRDQSSGDSWAGTGDQASG------------WF-------------CVCP
G---SQ-TNGGSWGGASGQDVGGSRPGPTNQSSAGSWDSPGSQVSGSSWTGAGAVDQVGG
CSKPGFEDQAIGGGFWPGAGDQTGGGSRPGSEDQS--SGIGSWGVAGGQVL---------
------------------------------------GGARP--ADQSSGGPWAGTG---N
QVSGRSWIGPG--NQ-AGDCSKPEFEDQ-ACGGGSWAGAGSQASGESWAGSTPGNE----
---AIGG-----S--RM-----------------GSE-----------------------
--------------------------DQATGGSWARSEDQASGRFQVSVEVEANEGFWFG
PGAEAVIGSWCWTEVKADIVSKPDDNNEATTTSRSEAGELAIICSRTEAE------NKAS
SGSWIRSEEVA--------YMGSCVGAEAGAEA--------------E--AGAEAE--AE
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-AGAGAGAGAEAGAGA-----------------------------RAGAEAEAGAGVWSW
DGDA------------------------TTVESRLGAGEEAGV-----------------
---ESWTLARD------V-GEDELSRESSP-DI-EEIS----------------------
-LRSLFWAESENSNTFRSK--------SGKD--VNFDSGAGDNT-SIKDKFEA-------
-AGGVDIGSWFCDGNENTNED-KSASKAKAKKSSE-S----------RGTYPSM-VPGAG
MGSW----DGAMIWSETK--FP------------HQ--SEASFPVED----E-----SR-
KQ-T-----------------------------------RT------------GEKPRPW
SCRCKR------EANMDPRDLEKLICMIEMTEDPSVHEIANNALYNSADYPYSH------
----------EAVRNVGGISVIESLLNNPYPSV------RQ-KALNALNNI-SVAAENHR
KVKTYLNQVCEDTVTYPLNSNVQLAGLRLIRHLTITSEYQHMVTNYISEF-LRLLTVGSG
E-TK-DHVLGMLLNFSKNPSMTKDLLIAN--------------KETK----------ENI
LNALSLFENINYHFKRRAKAFTQ--------DK-FSK--NSLY-FLFQRPKACAKKLRAL
AAECNDPEVKERVELLISKL----------------------------------------
-------------------------------------------

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---------------------XEIGASINT----EDL-----------------------
------------GIEAATGASWKPRPGV--------------------------------
-----VIGKWFWGGDKTSFDP-NPRPVYRTVKPWV---TCEIDERNRPKDWSEVTIWPNA
PAEIP---ASLASRYQVLSRTRPLS----CTAQSSAEKNTGSLPAA-------EASLREG
TSICLQSIDAYPFDSETCT--------------------QAIEKIRGQIRIRELNGIRPF
PCPCKM------ECRLNSEDFEKLVSLLKSNADPVIHKIAQIAMGIIKVHPLAQ------
----------QLVNEMGVLTVIESLLHFQFPDM-------TRKAEITL-NP-ISVEERQR
RIILHVVHMCKETVSFPLNSPGQRSGLKELGQLSADRDHHFIVAAYLPEL-SRMVSLGNH
K-TR-NLVLKVLLNMSENPIAARDMMNIE---VLSALKLIFHQKEAK----------ANL
VTAVAIFVNIKEHIRRGSIVVVN----------PVSY--NELK-AVFHEVKTIIEKL---
------------------------------------------------------------
-------------------------------------------

------------------------------------------------------------
--------------------------------------------MGRIQEVGWVTAGLVI
WAGTCYYIYKLTKGRAQSVRTLARNESTV-KMETVVE----VQNRTLATGAAE----IET
KSQAEIEAETGAGGGPRAEVETKATAIARHKANSQ----AKAMIGAAGEIQSE-------
SKVVAGTLVMTEAVTLTEAK--AKDREVAMKEAVTQTDAEAGKIVKKEAVTQTK-AKAWA
LVAKTEAKREAMTQTKAETHILAEKEVEINRVMVTQSETLAVPGE----VAKMGAMNKTG
IVDETKTRALEETVSVAKTQSEARPGSTVDARGNPNGMSREVAGVDLKSCAQSQTVIEIQ
GDDMPGARVEDMGNCK---------------------------TMSREESGADMRASAQP
QIVAKTQIEAIPGAKVDAGGNTNAMCKVGAGADVRTCI-QPQTVVKKQAEVTSGAR-ADG
RGNTNVISKAITGADMRAATQPQAVASPHAEAMSDAKVKERGSHNAMTKAGARTNLRANS
QVEALPNARDKSRGNPSVMAKMGDAADILSCM-QPQLVAIVQANTLSDGRIKVKGNVNSM
PKEGSGMDMKAQ--GMAQSHGEALPNTRGKSRAKAKAKCKTGAGMDTKTCAQPQAGVKTP
AEALPDSGVDGRGNLNAISKAGTKADQRACGQPLVVVNTQGEALPGAKNKAKGNPHAVPK
VGAGEGTTDSVQPQAV---------------------------------------VSFQG
EALLGTKNKVKGNPNAVLKAEVGAGAMGPAQLQIVASSKGEALLDSKNKAKGNSNAVSKA
GAGTDTMGSAQPQIVANSQSEVLPGAKNKVRGNPTTMSNSGTGPYI--------------
--------------------------TDSAQPHAVASSQGEVLPSAKNKGKANLHALSKA
EAGMGAT-----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------SSVQSQAVANSQGETLPGAKNK
VRGNWNTVSKAGTGMDTTGSAQPQAVTNSQSEVVPGAKNKVKGNPNVVSKAGAREDTMGS
AQP---------------------------------------------QVVANSQHETLS
GARNKVKGNSNAISKAETGSGIMGSVQVQVVASSHGKVLPGAKNKVRGN--SNAVPKAEA
GADTVGSGQLQAVANTQRETLLGARNKVKGNTKAVPKAGTGADTRDSSQPQIVTGSQ---
-------------------------------------GETLPRARDKAMPSSEAEATAED
EVYAKPE--AEAMPTSESEGGSGTQVCRKTQPDIHDYYWNGIGVEDWIAAERWIKFRFQT
MDGDWENGVSWADDENEASTGSWSGA-SDK--AGIISSWAVAC----DEASVKSWAGVRA
ENEVSIGTWVRAG-EQASGGLWVGGQTSEGTWAGD------------KASGGAWTVAENQ
ASGGTWVVAGNQAFGEIWAVGQASDGSWPGGQASGMSWVGEQAIGGSWTG--------AE
NQASGGSWAVV------------------------GAGNMSSVSYWAGVVDQASG-GSWA
GI------------SDQSGGGSKPRFEDQASGEGSWAGAGGQASGGSRLGPEEQSSGRSW
ADTADQASGGSRLGHVDQTSGG--------------------------------------
----------SWAGTLDQSGGGSKPRFENQTTEEG-SWAGAGGQAGGGSKLGPEDPSKGR
SWSNSGNQINGGFLVGVVDQANGGSWTGA----GHLASGGPKPIFEDQASGGGSWA-NAG
DRAVGDSRLGPRDQSSGDSWAGSGDQASG------------WF-------------CLCP
G---SQ-MNGGSWGVASGQDIGGSRPGPTNQSSAVSWDSTGSQVSGSSWTGVRAVDQAGG
CSKPGFEDQAIGGVFWPGAGDQAGGGSRPGSEDQS--SGRGSWGMAGGQVL---------
------------------------------------GGSRPGPADQSSGGSWAGTG---N
QSSGRSWIGPG--DQ-AGDYSKPEFEDQ-ACGGGSWAGAGNQASGESWTGSRPGNE----
---ATEG-----S--KM-----------------GSE-----------------------
--------------------------DQATGGSWARSEDQASGRFQVSVEVEANEGFWFG
PGAEAVIGSWCWTEEK-VIVSRSDDKDEATTESRSGAGEEAIICSRIEAE------NKAS
SGSWIRSEEVA--------HMGSSVGAEAGA-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------EA-----------------------------GSRLGAEAGAGAWSW
DGEA------------------------TTIESRLGARKEVGV-----------------
---ESWTLAQD------M-DEDDLSRESSP-DI-EEIS----------------------
-LRSLFWAESENSNKLRSK--------SGKD--VNFESGAGDNT-RIKDKFEA-------
-AGGVDIESWFCAGNENTSED-KSAPKGKGKKSPE-S----------RGTYPSM-VPGAG
MGSW----DGAIIWSETK--FP------------HH--SEASFPVED----E-----SK-
KQ-T-----------------------------------KT------------GEKTRSW
SCHCKR------EDNMDPQDFEKLICMIEMTEDPSVHEIANNALYNSADYPYSH------
----------EVARNVGGISVIESLLNNPYPSV------RQ-KALNALNNI-SVAAENHR
KVKTYLNQVCEDTVTYPLNSNVQLAGLRLIRHLTITSEYQHMVTNYISEF-LRLLTVGSG
E-TK-DHVLGMLLNFSKNPSMTKDLLIAN---APTSLINIFSKKETK----------ENI
LNALSLFENINYHFKRRAKAFTQ--------DK-FSE--NSLY-FLFQRPKACAKKLRAL
AAECNDPEVKERVELLISKL----------------------------------------
-------------------------------------------

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---------------------------------MGGARDVGWVAAG----------LVLG
VGACYYIYRLT--RGQRR-GAP--------RGPRLRP--SP-------------------
------------------------------------------SIXXX-------------
------------------------------------------------------------
--X----------------X--------XXXXXXXX---XX-------------------
------------------------------------------------------------
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---------------------------XX-------------------------------
------------------XXX-X----XXXX--------------XX---------X---
-------------------XXX------------XXXXX---------------------
---------------------------------------------------------XXX
XXXXX--------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX------
----------AIIRELGGIPIVGSMIASPNDSI------KE-KALNALNNL-SVNVENQE
IIKVYIDQVCEDVFSGPLNSAVQMAGLRLLTNMTVTNDHQHMFKSYITDI-FHVLLAGNG
I-TK-VQVLKLLLNLSENPAMAEGLFGAQ---VDASFLSLCDSHVAK----------EVL
LRVLTLFQNLNNCVKTDGSLVLRS-------TFMFHK--GSLFFLLYGQ--ECAQKMKAL
V-NHPDADVKEKVLIITFS-----------------------------------------
-------------------------------------------

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---------------------------------MGRTREAGCVAAG----------MVIG
AGACYCVYRLT--WGKDE-NEKLWD----DEDEEE-E--EEEESC---------------
------------------------SGKPEIGGKTV------KERKTHVGVGAGAKPQDDS
-----------------------------KS------------KAEANVGPENGPDVKKE
VYP----------------E--------SHSEGGLE---AKA------------------
-----------------KALFKS-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------L----------------------------------
----------------KEQASAKAGRGIRFPNIS--------------------------
---------------------------------------------RIRTLTSSLPCPGGR
GG---------GCHPGRTGSRA---------------------------------RNRTS
GKVKRKNRSKSNKAPA-T---------------------------AW----PVRRGKFSF
PYKID--------DILSAPDLQKVLNILERTNDPFTQEVALVTLGNNAAYSFNQ------
----------NAIRELGGVPIIAKLIKTRDPII------RE-KTYNALNNL-SVNSENQG
KIKTYISQVCDDTMVCRLDSAVQMAGLRLLTNMTVTNHYQHLLSYSFPDF-FALLFLGNH
F-TK-IQTMKLIINFTENPAMTRELVSCK---VPSELISLFNKEWDR----------EIL
LNILTLFENINDNIKSEGLASS---------RKEFSR--SSLFF-LFKESGVCVKKIKAL
A-SHKDLVVKVKVLKVLTKL----------------------------------------
-------------------------------------------

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-------MTGAEIESGAQVKPEKKPGEEV--------VG-----------GAEIENDVPL
VVRPKV--------------------------RTQ--ATTGARPKTETKSVPGARPKTDA
------QAMSGA------------RPKT----------------------------DAQI
MGGARPKT----------------------------EAQGMAGARPKTD------ARAVG
GARPKT--DAKAIPGTRPKDEA--------------Q--------------AWAQSEFG-
-----TEAVSQAEGVSQTNAVAWPLATAES--GSVNKSKGLSMDRELVDVDAETFPGTQ-
-GQKGIQPWFGPG-EETN------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
---MGSWCYSRPRAR-EEASNESGFWSADETSTVSSFWAGEETSIRSWPREDS---NTRS
RHRAKHQ-----T--NPRSRPRSKQEAYVDS-WSGSE-----------------------
-DEAGNLFSFWAGENTSNLF----------------------------------------
---------------------RPRVREEANIRSKLRTNREDC--FESESE------DEFY
KQSWVLPGEEA---------NGR-----FRCRDKEDPNTALKPR----------------
AQ----KDV-DGDRVKQEPRF-----EEEVIIGSWFWAEKEV------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------SL
EGG------ASAICESEPGTE-----EGAI------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------GGSTYWAEEKS
SLGA--------------------------------------------------------
-----------------------------------------------VAREEAKPES---
------------------------------------------------------------
------------------------------------------------------------
-EEEAIFGSWFWDRDEACFDL-NPCPVYKVSDRFRDAA-EELNASSRPQTWEEVTVEFKP
-GLF----HGVGFRSTSPFRIPEEAS-----EMLEAKPKNMELSPEG----E--EQESLL
QPNQ--PDPEFTFQYDPSY--------------------RSVREIREHLRARESAESEGW
SCSCIQ-----CELKIGSEEFEELLLLMDKIRDPFIHEISKIAMGMRSASQFTR------
----------DFIRDSGVVSLIETLLNYPSSRV------RT-SFLENMIHM-APPYPNLN
MIETFICQVCEETLAHSVDSLEQLTGIRMLRHLTMTIDYHTLIANYMSGF-LSLLTTANA
R-TK-FHVLKMLLNLSENPAVAKKLFSAK---ALSIFVGLFNIEETN----------DNI
QIVIKMFQNISNIIKSGKMSLID---------DDFSP--EPLI-SAFREFEELAKQLQAQ
IDNQNDPEVGQQS-----------------------------------------------
-------------------------------------------

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---------------------------------MGRTREAGCVAAG----------MVIG
AGACYCVYRLT--WGKDE-NEKLWD----DEDEEEEE--EEEKSC---------------
------------------------SGK------TE------KELKTNVGVGAGGKPQDDS
-----------------------------KS------------KVEVNVGPENGPGLKKE
VHP----------------E--------SQSGGGLE---AKA------------------
-----------------KALFKT-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------L----------------------------------
----------------KEQARAKAGRGIRLPNIS--------------------------
---------------------------------------------RNRTLTSSLPCPGGR
GG---------GCHPGRTGSRA---------------------------------RNRTS
GKVKRKNRSKSNKAPA-T---------------------------AW----PVRKGKFSF
PYKID--------DILSAPDLQKVLNILERTNDPFTQEVALVTLGNNAAYSFNQ------
----------NAIRELGGVPIIAKLIKTRDPII------RE-KTYNALNNL-SVNSENQG
KIKTYISQVCDDTMVCRLDSAVQMAGLRLLTNMTVTNHYQHLLSYSFPDF-FALLFLGNH
F-TK-IQTMKLIINFTENPAMTRELVSCK---VPSELISLFNKEWDR----------EIL
LNILTLFENINDNIKSEGLASS---------RKEFSR--SSLFF-LFKESGVCVKKIKAL
A-SHKDLVVKVKVLKVLTKL----------------------------------------
-------------------------------------------

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---------------------------------MGRTREAGCVAAG----------VVIG
AGACYCVYKLT--WGRDE-NEKILD----EDKESTDT--S--------------------
----------------------------ETGVETV------KGAKANVGAGSGAKL-HSD
------------SKVK--------PEVSLGL------------EN--------CPGVKEK
VHS----------------G--------SHSGGGLE---AKA------------------
------------------------------------------------------------
-------KALFNM-----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------L-KE--------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------QASAKAGKGVRVGII---------------------------
-----------SG---------------------------------NRTLAPSLPCPGGR
GG---------GCHPTRSGSR-------------A--------------------GGRAS
GKSKGKARSKSTRAPA-T---------------------------TW----PVRRGKFNF
PYKID--------DILSAPDLQKVLNILERTNDPFIQEVALVTLGNNAAYSFNQ------
----------NAIRELGGVPIIAKLIKTKDPII------RE-KTYNALNNL-SVNAENQG
KIKTYISQVCDDTMVCRLDSAVQMAGLRLLTNMTVTNHYQHLLSYSFPDF-FALLFLGNH
F-TK-IQIMKLIINFTENPAMTRELVSCK---VPSELISLFNKEWDR----------EIL
LNILTLFENINDNIKSEGLASS---------RKEFSR--SSLFF-LFKESGVCVKKIKAL
A-NHNDLVVKVKVLKVLTKL----------------------------------------
-------------------------------------------

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--------------------------------------------------------PWAR
IWVELGPGLEARAKARKT---------------------------RR----PVAVQKRPF
PYEID--------EILGVRDLRKVLALLQKSDDPFIQQVALLTLSNNANYSCNQ------
----------DTIRKLGGLPIIANMINKSDPHI------KE-KALMAMNNL-SENYENQG
RLQVYMNKVMDDIMASNLNSAVQVVGLKFLTNMTITNDYQHLLVNSIANF-FRLLSQGGG
K-IK-VEILKILSNFAENPDMLKKLLSTQ---VPSSFSSLYNSYVES----------EIL
INALTLFEIIYDNLRAEVFN-----------YREFNK--GSLFY-LCTTSGVCVKKIRAL
A-DHHDLLVKVKVIKLVDK-----------------------------------------
-------------------------------------------

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-----------------------------------------------MGRARE--VGWMA
AGLM----IGAGACYCVYKLTL------------GR--DDSNKLEE------E-EEEWDD
DQELDEEEPEIWFDFTTMARPWSEDGDWTEPGTPGGTEDRPSGGGKANRT--HPVKQRPF
PYEHK--------NTWSNQSFRNFSCVPDLSKCPFIQGKMWFAQPKDAGFSSIH------
----------NINSHLASLSIVGNTIPTPDPAI------KE-KALCAPDNL-NASIENQG
QIKMYINEVCRETVSHCCNSFLQQAGLNLLISMTVINN---MLAKSVSDLKFPLIAEGSG
C-AE-LQVLKLLMGLSEKPVLAGELLGAQ---MLLSFMSLFMRNGNR----------QVL
LDTLAS------------------------------------------------------
------------------------------------------------------------
-------------------------------------------

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-----------------------------MAGAR--NRRNRNRKN--EK-KKAKTEKR-A
VVEAE--GKREATAT------VKSAEG--------------------KTQAKAISKAGPR
-----ADAG---------------------------------------------------
------AVVKAA-------------SKNKTGTETKE-RLPDVRPKAEDEATR---TARFC
SA---AQA----------------------------TAES-----RLTCKDKTRTDTLFG
AGEE------------------------ANVGSWFCNGEKIGK-HFSA------------
---------KDEGK-------ADTGPPSCA----E-------------------------
------------KLEPVAGTSCKARPGAEE------------------------------
EEEENVIGSWFWDGDETSFDP-NPRPVSRIIKPQP---VDEINEKDRPKDWSEVTIWPKA
PAVTP---AVLGFRSQVTFEKKPPS----YFVLASAEENTCSSPVA-----TAAARPSRS
TPSSSQPVSEFPFGSDPCI--------------------QTIEEIRRQIRIREVNGIKPF
ACPCKM------ECYMDSEEFERLITLLKSTTDPLIHKIAQIAMGIINVHPFAQ------
----------EFINEVGVVTLIESLLSFPSSEM-------RKKAVITL-NP-PSGDERQR
KVELHVKHMCKETISFPLNSPGQQSGLKILGQLTTDSNHHHIVANYFSEL-FHLLSLGNR
K-TR-NLVLKVLLNMSENPTAARDMTNTE---SLAALKLIFNQKEAK----------ANL
VSAVAIFINIKEHIRKGSIVVVD----------HSSY--TTLM-AIFREVKAIIETM---
------------------------------------------------------------
-------------------------------------------

------------------------------------------------------------
--------------------------------------------MGRTQEVGWVTAGLVI
WAGTCYYIYKFTKGRAQSVRTLARNGSTV-KMETVVG----VQSQTLAKSEAE----IKT
KPQAEIGAETGTRGGPGAEVETKATAIARHRANSQ----AKTMVEAEAETQSE-------
SKVVAGTLVMTEAVTLTEVK--AKAREVAMKEAVTQTDAEAGKIVKKEAVTQTK-AKAWA
LIAKTEAKREAMTQTKAETHILAEKETEINRVMVTQSETLAVPKE----VVKMGATNKTG
IVDETKTRALEETVSVAKTQSEARPGATVDARGNPNGMSREVAGVDMKSCAQSQAVTKIK
GDDMPGAGIEDMGNCK---------------------------TMSRAESGADTRASAQP
QIVAKTQTEAIPGAKVDAGNNANAMCKVGAGADVRACV-QPQTVVKKQAEVTSGAG-VDG
RGNTNVISKAITGADMRAAAQPQAVASAHAEAMSDAKVKDRGNSNAMTKAGARANLRANS
QVEALPDARDKSRGNPNVIAKAGDGTDMLSCT-QPQLVASVQANTLSDGRIKVKGNVNTM
PKEGAGVDMKAQ--GMAQSQGEALPNTRGKARGKAKAKCKTGSGMDMKTCTQPQTGVKTP
AEALLDSRVDGRGNPNATSKAGTKADQRACGQPLVVANPQGEALPGAKNKVKGNPHAVLK
VGAGEGTADSAQPQAV---------------------------------------VSFQG
EALLGTKNKVKGNPNVVLKAEVGADAMGTAQLQIEASSKGEALLDSKNTVKGNSNAVSKA
GAGTDTTGSVQPQIVANSQGEVLPGAKNKFRGNSTTVPNSGVGPYT--------------
--------------------------TDSAQPQAVANSQGEVLPGAKNKVKANLNALSKA
EAGMGAT-----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------GSVQSQAVANAHCETLPGAKNK
VRGNWNAVSKAGAGMDTRGSAQTQAVANSQGEVLPGARNKVKGNPNVVSKAGAKEDTMGS
AQPQVVANSQRETLPGARNKVKGNPNVLSK-----AGAKEDTMGSAQPQVVANSQRETLP
GARNKAKGNSNAISKAEAGAGIMGSVQVQVVASSQGEVLPAAKNKVRGN--SNAVPKAEA
GADTVGSAQPQAVANSQSETLLGARNKVKGSTNTVPKAGTGAGTRHSAQPQIVAGSQ---
-------------------------------------GETLPGARDKAMPSSEAETTAEG
EVYAKPE--AQAMPISESEGGSGTQACRKTQLNIHDYYWNGIGVEDWIAAERWIKFRFQT
MDGDWENSVSWADDENEASIGSWSGA-SDK--AGIIRSWAVAC----DEASVKSWAGARA
ENEVGIGTWARAG-EQASGGLWAGGQPSEGTWAGD------------KASGGAWTGAENQ
ASGGSWVLAGNQAIGELWAVGQASNGSWPGGQASGVSWVGAEAIGGSWTG--------AE
NQASGGSWAGA------------------------GAGNMSSVSYWAGVVDQASG-GSWA
GT------------SDQSGGGSKPRFEDQASGEGSWAGAGDQASGGSRLGPEDQSSGRSW
ADTADQASGGSSLGHVDQSSGG--------------------------------------
----------SWAGTLDQSGGGSKPIFENQTTEEG-SWAGAGGQAGGGSNVGSEDQSSGR
SWANSGDQISGGFLVGVVDQANGGSWTGA----GHPASGGPKPIFEDQASGRGSWA-DAG
DQVVGDSRLGLRDQSSGDSWAGTGDQASG------------WF-------------CVCP
G---SQ-TNGGSWGGASGQDVGGSRPGPTNQSSAGSWDSPGSQVSGSSWTGAGAVDQVGG
CSKPGFEDQAIGGGFWPGPGDQTGGGSRPGSEDQS--SGIGSWGVAGGQVL---------
------------------------------------GGARP--ADQSSGGSWAGTG---N
QVSGRSWIGPG--NQ-AGDCSKPEFEDQ-ACGGSSWAGAGSQASGESWAGSTPGNE----
---ATGG-----S--RM-----------------GSE-----------------------
--------------------------DQATGGSWARSEDQASGRFQVSVEVEANEGFWFG
PGAEAVIGSWCWTEAKADIVSKPDDKDEATTASRSEAGEEAIICSRTEAE------NKAS
SGSWIRSEEVA--------YMGSCVGTEAEAE------------------AGAEAG--AE
AE----------------AG----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-AEAVAEAEAEAGAEA-----------------------------GAEPGAEAGAGVWSW
DGDA------------------------TTVESRLGAGEEAGV-----------------
---ESWTLARD------V-GEDELSRESSP-DI-EEIS----------------------
-LRSLFWAESENSNTFRSK--------SGKD--ANFDSGAGDNT-SIEDKFEA-------
-AGGVDIGSWFCDGNENTNED-KSASKAKAKKSSE-S----------RGTYPSM-VPGAG
MGSW----DGAMIWSETK--FP------------HQ--SEASFPVED----E-----SR-
KQ-T-----------------------------------RT------------GEKPRPW
SCRCKR------EANMDPRDLEKLICMIEMTEDPSVHEIANNALYNSADYPYSH------
----------EAVRNVGGISVIESLLNNPYPSV------RQ-KALNALNNI-SVAAENHR
KVKTYLNQVCEDTVTYPLNSNVQLAGLRLIRHLTITSEYQHMVTNYISEF-LRLLTVGSE
E-TK-DHVLGMLLNFSKNPSMTKDLLIAN---APTSLINIFSKKETK----------ENI
LNALSLFENINYHFKRRAKAFTQ--------DK-FSK--NSLY-FLFQRPKACAKKLRAL
AAECNDPEVKERVELLISKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
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-------MTGAEIESGAQVKPEKKPAEEVV--------G-----------GAEIENDVPL
VVRPKV--------------------------RTQAQIMPGARPKNKSKVMPGASTKV--
------------------------------------------------------------
------------------------------------------------E------TSAVG
GARPKS--KAKAIPVSRFKEEA--------------Q--------------MWAQPRFG-
-----AERLSKTERNSQTNIIASPLVSTDS--VLVAKTKYLSEDRELVNTDTESFPRRKA
HYQAGFQPSFRSK-EETN------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---MGSWCCPRPTSK-QEASPNSDFKWVDQS-VSSLFWSGDEVTAKFHPGNRVKD-SNRS
MHMANQE-----A--NTMSRSQTNQELYIAS-SSGSE-----------------------
-DESVKTPWFWARDKTNTWS--GPREDP-NSRSRFRSKKEVYV------------ESSSG
SEHEDHLESWFGAGKEAKFRSKMRAGKEANNRARHRAKREACIDFMPGSI------DVIK
KESCVWPEENA---------NTF-----SRPMIKKEARARAMTK----------------
EE----AKTKARARAKQEARS-----EEEALIGTWFWATDESSMADEASIESSLQVEDES
IIGSWFWTEEEASMGTGASSNS-RPRTDGEHIGDSLFGAR-EKTSMKTGAEATSESILAA
DDE-QVIIGSWFWAGEE-VN---------------------------------QEAEEET
IFGSWFWVIDAAS-VESGVGVSCE-------------------------------SRTR-
-SEEEEVIGPWFWSGEQVDIEAGIGEE----------ARPGAEEETIFGSWFWAENQTYM
DCR------AETSCDTMQGAE----EEEPIIGSWFWTRVEACVEGDVNSKSSLEDKEE-A
MI-PCFGAKEEVSMKHGTGVRCRFMAGAEETNNKSCFWAEKEPCMYPAGGGSWKSRPEEE
-----EDIVNSWFWSRKYTKPEAIIG------------------------SWLWATEESN
I-DGTGEKAKLLTEEETIINSWFWKED-EAISEATDREESRPEAEEGDIIGSWFWAGEED
RLEPAAETREEDRLAAEKE-GIVGSWFGAREETIRREAGSCSKSSPKAEEEEVIIGSWFW
EEEASLEAVAGVGFESKPGTEEE----EITVGSWFWPEEEASIQAGSQAVEEMESETEEE
TIFGSWFWDGKE-----VGEEAGPCCVSKPEDD-EEMI----------------------
-VESWFWSRDKAIKETGTVATCESKPENEEGAIVGSWFEAEDEVDNRTDNGSNCGSRTLA
DEDEAIVGSWFWAGDEAHFES-NPSPVFRAICRSTCSVEQEPDPSRRPQSWEEVTVQFKP
-GPW----GRVGFPSISPFRFPKEA-ASLFCEMFGGKPRNMVLSPEG----E--DQESLL
QPDQ--PSPEFPFQYDPSY--------------------RSVQEIREHLRAKESTEPESS
SCNCIQ-----CELKIGSEEFEELLLLMEKIRDPFIHEISKIAMGMRSASQFTR------
----------DFIRDSGVVSLIETLLNYPSSRV------RT-SFLENMILM-APPYPNLN
IIQTYICKVCEETLAYSVDSPEQLSGIRMIRHLTTTTDYHTLVANYMSGF-LSLLATGNA
K-TR-FHVLKMLLNLSENLFMTKELLSAE---AVSEFIGLFNREETN----------DNI
QIVLAIFENIGNNIKKET-VFS---------DDDFNI--EPLI-SAFHKVEKFAKELQGK
TDNQNDPEGDQEN-----------------------------------------------
-------------------------------------------

------------------------------------------------------------
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-----------------------------------------------MGRARE--VGWMA
AGLM----IGAGACYCVYKLTI------------GR--DDSEKLEE------E-EDEWED
NQELDEEESQMWFDFITMARPWNEDGDWTEPGAPDGTENRLSGGGKANRI--HPTRQRPF
PYKHK--------NTWNAESLNIFSCALGLSKGPFIQGKM-FAQPEDAGFSFSH------
----------NISSHLASLPVVGNTIPTPDPTV------KQ--AFCALDGE-SAGVENQG
QIKMSVSEVCRETVSHCCNSFLQQAGLNLLISMTVINN---MLAKSVSDPRFPLISEGSG
C-AE-VHVLKQLMGLSEKPVLAGELLGPQ---MLLSFMPLFIGNGNG----------QVL
PDTLAS------------------------------------------------------
------------------------------------------------------------
-------------------------------------------

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---------------------------------MGRTREAGCVAAG----------VVIG
AGACYCVYRLA--WGRDE-NEKIWD----EDEESTDT--SE-------------------
-----------------------------IGVETV------KGAKTNAGAGSGAKLQGDS
-----------------------------EV------------KPEVSLGLEDCPGVKEK
AHS----------------G--------SHSGGGLE---AKA------------------
-----------------KALFNT-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------L----------------------------------
----------------KEQASAKAGKGARVGTIS--------------------------
---------------------------------------------GNRTLAQSLPCPGGR
GG---------GCHPTRSGSRA---------------------------------GGRAS
GKSKGKARSKSTRAPA-T---------------------------TW----PVRRGKFNF
PYKID--------DILSAPDLQKVLNILERTNDPFIQEVALVTLGNNAAYSFNQ------
----------NAIRELGGVPIIAKLIKTKDPII------RE-KTYNALNNL-SVNAENQG
KIKTYISQVCDDTMVCRLDSAVQMAGLRLLTNMTVTNHYQHLLSYSFPDF-FALLFLGNH
F-TK-IQIMKLIINFTENPAMTRELVSCK---VPSELISLFNKEWDR----------EIL
LNILTIFENINDNIKNEGLASS---------RKEFSR--SSLFF-LFKESGVCVKKIKAL
A-NHNDLVVKVKVLKVLTKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
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-----------------------------------------------MGRARE--VGWMA
AGLM----IGAGACYCVYKLTI------------GR--DDSEKLEE------EGEEEWDD
DQELDEEEPDIWFDFETMARPWTEDGDWTEPGAPGGTEDRPSGGGKANRA--HPIKQRPF
PYEHK--------NTWSAQNCKNGSCVLDLSKCLFIQGKLLFAEPKDAGFPFSQ------
----------DINSHLASLSMARNTSPTPDPTV------R--EALCAPDNL-NASIESQG
QIKMYINEVCRETVSRCCNSFLQQAGLNLLISMTVINN---MLAKSVSDLKFPLISEGSG
C-AK-VQVLKPLMGLSEKPVLAGELVGAQ---MLFSFMSLFIRNGNR----------EIL
LETPAP------------------------------------------------------
------------------------------------------------------------
-------------------------------------------

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-----------------------------------------------------RSV----
----ANPANVSFEKDVATKAS-SKNKVVEKE--RTLSEHAL--RKGMEGFASIRC-----
-----AFKEKTEDERKVFWSE-----EETSIGTHFTGGEEAG------------------
----------------------------------------------DGSSSKYKE-----
---------------------------------------------------------ASS
SDVELG-------------------------------IKS--------------------
----ATGAN-CTP--R-----------------------------PEAEEEEDLVGNWLW
DGDE------------------------TSFDPNPIFL----------------------
----CRTVKPQI--------EDEFDWL---KDW-D-----PSS-----------------
-IPALLSFTSQLPMSMRTLS-------Y-------IDLSSERK-----------------
--------------------------------------------------NPSLSV--GE
AILC----EVTNICLHSIQKYP------------FD--SGIFT-HT------------R-
LG-I-----------------------------------R------------KLNGVKPF
-CSRKM------ECCSDAEEFERLISLIQSNVYPLIHKIAQIVVDVIKVNPFVQ------
----------QLINEMGVLTVIENFLDFQTPNV------QK-AI--TLESI-SVE-----
-----KRHVHMEEAVLPWNSPXXXXXXX--XXXXXXXXXXQQIVNCHTGL-FNTLAQGNC
K-TR-NVILKILLNVSENPIADMIDLEL------SELKEVFSKDAKS----------NLV
TA-VAIFVNIKEHIRKGPNIIVN--------PSSYNKLKEMFYEVKFI------EKL---
------------------------------------------------------------
-------------------------------------------

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--------------------------------------STGWV-----------------
----YLIFRKK--KQKML-LAH---------SALLKE--KR-------------------
------------------------------------------STK---------------
------------------------------------------------------------
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---------------------------------------------------------DLT
SGSYD--------DTLNAEQVQKLLYLLESTEDPIIIERALVTLGNNAAFSANQ------
----------IVIRELGGIPIVGSKINNPNQSI------KE-KALNALNNL-SVNVENQV
KIKVYVSQVCEDVISGPLNSAVQLAGLRLLTNMTVTNAHQDMLSSYITDL-FHVLVTGNG
S-TK-VQVLKLLLNLSENPAMTDQLLDAQ---VDSSFLSLLDGHVPK----------EIL
LRALTLLQNITDCLSEERRLAT---------QTAFPA--GSLFSLLYGK--ECAQKMKAL
V-HHHDADVKEKVTM-IPKF----------------------------------------
-------------------------------------------

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---------------------------------MSRVRDAGCVAAG----------IVIG
AGAWYCVYKYA--GERAQ-TKKRLV----KPKTRAGPVVGTGARARVGLKAGFTIDLGPE
FSPPILVQAGAEDR-ARNEAFALESVGAQAVVPAA------ASAEAQIGEGSQTQEPNGA
--GVEPKA-ESIVGATEVSAMAAPLRVAEAT------------WVAEATTVAEAPKLADF
SST----------------V--------EAPVAV--PPGTAEGPGT--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------KEVS
GTAALTEASEAPKSAAP------------------------------AGTTEAPR-----
--AVV-----------PTSAS-----------------E-AP------------------
----------------------GTSGSPR-------------------------------
-----------TVAVPGTAAAKRTTPGAHTGAIPKAGS--STGA---VPKGGA-------
-----------KGGTKSRTGG-K----GKGKR------------N--K-----VDMGFRL
R-----------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------WGCC-------
----------SCCXKLGGLPIIANMINKTDPHI------QE-K-LMALNNL-SENYENQG
RLQVYMNKVMDDIMASNLNSAVQVVGLKFLTNMTITNDYQHLLVNSIANF-FRLLSQGGG
K-IK-VEILKILSNFAENPDMLKKLLSTQ---VPASFSSLYNSYVES----------EIL
INALTLFEIIYDNLRAEVFN-----------YREFNK--GSLFF-LCTASGVCVKKIRAL
A-NHHDLLVKVKVIKLVDKF----------------------------------------
-------------------------------------------

-----------------------------MNLYIYFRVYHQTREGKRRELPWIITGLLPV
AAVVAFEWLKISTLIDLHLSLSPSFPSPSEPPLYFICVFSRGDYMGRVQEVGWVTAGLAI
WAGTCYYLYRLTKGRSQSVTRLARNGSRV-KTETVVG----VQNQTLAMSEALAGVEIET
RPKAKTGAETGEGSEPGAEVETKVTAIERSKANSQ----SKAMVGAEAEIQSE-------
AKSVARTLVMTDAVTLTEVK--VKAREVSMKEAMTQTDAEAGEIVKKEAVTQTK-AKAWA
LVSKTEAKKEAMTQTKAETQTLVEKETEINRVMVTQSEVLAVTKE----VVKIGTMNKTG
IAVESKTRALEETVSVLTTQSDSRFGTTVDSKKNPNGMSRAVAGMDMKSCARSQAVAKIQ
DDDMPGA--EDKRNLK---------------------------TMCKAASKVDTRASPQS
QIVVKGQAEAMPGTRVDMEGNIITMCKAEVGTNVRACIIQPQIVAKKQAEAMSGAR-VDT
----SVIPKAITGNVIRAAAQIHAVACAQTESMPDARVKGRANPNAMVRASAMANMRTNL
QAEALPDNSYKTKSDLSVMAKAGAGIDMLFYT-HAQPVANIQSDALPDGRIKAKGTVNAV
IKEGAQV--------MAQSQGEALPNTKGKARGKAKAKCKAGVGPDMKTYSQSQAGTKTQ
GEALPDSRVDGRGDSNAISKAGAKADHENCGQLQAVVNSQGDALPGTRNKFKGYPNAVSK
AEARTATADSAQPQVLVCSQSETLIAAKSKS-----------------------------
----------RGNRNVVPKA----------------------------------------
ETGAATTSSAQPQTVNSSKGEALPGAKNKVKGNLNAVPKTETGVVI--------------
--------------------------TGSVFPQALASFQGET------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------IIGTRTKVKGNPSAMSKPEAGAGTK--
--------------------------------------DSSQSQTVASSQDETMFGARSK
VR----------------------------------------VNCNVP-KAEVGAGAVGS
SQSQTVACSQGEALLGARNKVRSSPSAVPKAK-----AEAGTVSSSQPQALTISQNEALL
NARNKVRGNSNAMPKVGSQKATKVSAQPQVVASSQ-------------------------
------------------------------------------------------------
-------------------------------------DEVLLGIMDKAMSRSEAEATAED
KVYAKPE--AGAMPTSESEGEPDAQACRKTQSNIHGYYWNGIGVEDWIAAERWIKFRLQA
MDGDWENSVSWAD-ENETSIGSWSGT-GDK--PGIVSSWAVAC----DETTVKSWPGARA
ENQSALGSWVGAG-DQASGGLWAASHVSEASWGGDKV-GGSWVQAENKAIAGSWTGAENQ
VSGASWVVSGNQAIAGPWAVGQVGEVSWPAVQATGLSWVVDQTGRGSWT--------VAE
NQASGVSWAGA--------------------------GNIVSIGYWTGAVDQANAGGPWF
GT------------VDQSGSESKPRFEDQAGAS-------AQASGDSSLGPENQSGGRSW
ADTADQASGGSRPGPIDQSNGASWVGPGEQAGGRSTPGSEDQSSGASWAGTRNL------
------AREGSWTGT------------------------GAFGQDGEVSKSGPEDQSSGR
SWADSGDQISGRFLVGVVDQANGESQVRP----GDLAGGETKPVFEDQATGGRCWTN-AE
DQSVRESRLGPRGQSNIDSWPGTVNQASG------------WF-------------CTYT
G---SQISGGGSWGGTGGQHVGSSRPGPMNQALGGSWAGSGSQISGVSWAVA--GDQAGG
CLKPGFENQAIGAGFWAGAGNQPCGGSRPGSEDQS--VGGGSWTGAGVHVI---------
------------------------------------GASRPDPTDQSSGASWGGTG---N
QVSGGSWVGLA--DK-GVGCFRSGFEDQ-AHGGSTWAGAGDQTGGESWAVSRPGNE----
--------------------------ASGG------------------------------
--------------------------------SRLSSEDQTSGRFLVSAEVETSEGFWFA
PGSEAFIGSWGCTREEVDTVSRPDGKDEASTESTSEPKEKTIISSELGDE------NKAS
TGSWNRSEEVV--------YM----GSCVRAESGSETGAAVEAE--AGAEAEAGA-----
------------------------------------------------------------
------------------------------------------------------------
E-----------------------------------------------------------
------------------------------------------------------------
-----------------------AGAETGTE------------------SGAE-------
-------------------TG-----TEA------------------GTESGAET-----
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------GTEAAA----
--EAGADVGAEAGAEA-----------------------------GADVGAEARIGSWSW
DGQA------------------------TTKGFGLRLKEETTIRS---------------
---WSWALARD------V-DEDELSEPSSP-DI-EEIS----------------------
-LRSLFWAESDNSNEFRSK--------SEKD--FDFKSEIGDEA-SIKDNFEA-------
-ADGVDIRSWFCTGNESRSED-KSTLKSKAKKSAE-S----------RGTYPFM-VPGAG
MSSW----DGAVIWSEMK--FP------------HQ--NESSFPAED----Q-----FR-
-Q-I-----------------------------------RA------------GEKVRPW
PCRCKR------EANLDPRDLEKLICMIELTEDPSVHEIASNALYNSVDYPYSH------
----------EVVRNVGGISVIESLLNNPYPSV------RQ-KALNALNNI-SVAAENHR
QVKTYLSQVCEDTVTYPLNSNVQLAGLRLIRHLTITSEYQHMVTNYISEF-LRLLTVGSG
E-TK-DHVLGMLVNFSKNPSMTKDLLIAN---APTSLINIFSKKEKK----------ENI
LNALSLFENINYHFKRRAKAFTQ--------DK-FSK--NSLY-FLFQRPKACAKKLRAL
AAECSDPEVKERVEILINKL----------------------------------------
-------------------------------------------

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-------------------------------------DYHMLVTKYMSGF-LSLLAMGNT
K-TR-FHVLKMLLNLSENPVMTKVLLSAK---AMSEFMELFKRKETN----------DNI
QVVLAMFENIGNNIKKEVMLFT---------DDDFSL--EPLI-SAFHEVEEFAKELQGK
TDDQNNPEEDQEN-----------------------------------------------
-------------------------------------------

------------------------------------------------------------
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-GACYCIYRLT--RGRKQNKEK-MA----EGGSGDMD--DVG----------------DC
---------------------------------------------------------PGA
--RYNDWSDDD-------------------------------------------------
DDN----------------S--------E-------------------------------
------------------------------------------------------------
-NKGIVWYPPWAR-----------------------------------------------
------------------------------------IG----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------T--------------------------------
-----------EAGTRARARA---------------------------------------
------------------------------------------------------------
-------------RARAT---------------------------RA----RRAVQKRAS
PNSDD--------TILSPQELQKVLCLVEMSEKPYILEAALIALGNNAAYAFNR------
----------DIIRDLGGLPIVAKILNTRDPIV------KE-KALIVLNNL-SVNAENQR
RLKIYMNQVCDDTITSRLNSSVQLAGLRLLTNMTVTNEYQHMLANSISDF-FRLFSAGNE
E-TK-FQVLKLLLNLAENPAMTRELLRAQ---VPSSLGSLFNKKENK----------EVI
LKLLVIFENINDNFKWEENEPT---------QNQFSE--VSLFF-FLKEFQVCADKILGI
E-SHHDFLVKVKVGKFMAKLAEHMFPKSQE------------------------------
-------------------------------------------

------------------------------------------------------------
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-----------------------------------------------MGRARE--VGWMA
AGLM----IGAGACYCVYKLTI------------GR--DDSEKLEE------E-EEEWDD
EQELDEEEPEIWFDFTTMARPWSEDGDWNEPGAPGGTEDRPAGGGKANRT--HPVKQRPF
PYERK--------NTWSAQSFKNFSSVLGLSKCPFIQGKVLLAQPRDTGFSFSH------
----------DINSHLASLSIAGNTIPIPDPAV------E---AFCALDNL-KASVENQG
QIKMYINEVCRETVSLCCNSFLQQAGLNLLIIMTVINN---MLAKSVSDLKFPLIPEGSE
C-AE-GHVVKPLMGLSEKPVLAGELLGAQ---MLLSFLSLFIRNANR----------QLL
PEIPAS------------------------------------------------------
------------------------------------------------------------
-------------------------------------------

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------------------ADIENFSCVLGLSKCPFIQGKVLLAQPRDTGFSFSH------
----------DINSHLASLSIAGNTIPIPDPAV------E---AFCALDNL-KASVENQG
QIKMYINEVCRETVSLCCNSFLQQAGLNLLIIMTVINN---MLAKSVSDLKFPLIPEGSE
C-AE-GHVVKPLMGLSEKPVLAGELLGAQ---MLLSFLSLFIRNANR----------QLL
PEIPAS------------------------------------------------------
------------------------------------------------------------
-------------------------------------------

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---------------------------------------MTGSKN--KARAQAKLDKR-A
SGQAKALAEREAANA------GRAG---------------------GKNRDKGKPKWGNK
-----ADAA---------------------------------------------------
------SETRGG-------------SKGRAAAEMKEGGRSEHKALGKD------------
-------F----------------------------NHKYEYKGARSSRKEKASSDTWFW
TGEE------------------------SGLNSWFWKGEEVSY-DTVP------------
---------QCENK-------SNTGTQGRT----E-------------------------
------------ESEPTPKASHKSR--AEE------------------------------
EEEENVIGNWFWEGDDTSYDP-NPKPVFRIVKPQP---VDEINEKNRPKDWSEVTIWPKA
PAVTP---AVLGYTSQDSSESRPSS----FIVLASNEEKASK------------TACTKN
TRSGLQPIPEYPFGSDPCI--------------------QTLDEIRQQIKIREMNGIKPF
ACPCKV------ECYLDSPEFEKLVNILKSTTDPLIHKIAQIAMGLHKVHPFAR------
----------EFINEVGVVTLIESLLSFSSPET-------RKKTVITL-N--SSGDDRQH
KVEFHVKHMCKETVSFPLNSPGQQSGLKIIGQLTTESVHHYIVASYFSEL-FHLLSQGNR
K-TR-NLVLKVFLNMSENPKAARDMINMK---ALAALKLIFNQKEAK----------ANL
VSAVAIFINIKEHIRKGSIVVVD----------HLSY--STLT-AIFREVKGIIERM---
------------------------------------------------------------
-------------------------------------------

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---------------------------------MGYARKVGWVTAG----------LVIG
AGACYCIYKLT--RGRKQNKEK-MA----EGGSGDVD--DAG----------------DC
---------------------------------------------------------SGA
--RYNDWSDDD-------------------------------------------------
DDS----------------N--------E-------------------------------
------------------------------------------------------------
-SKSIVWYPPWAR-----------------------------------------------
------------------------------------IG----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------T--------------------------------
-----------EAGTRARARA---------------------------------------
------------------------------------------------------------
-------------RARAT---------------------------RA----RRAVQKRAS
PNSDD--------TILSPQELQKVLCLVEMSEKPYILEAALIALGNNAAYAFNR------
----------DIIRDLGGLPIVAKILNTRDPIV------KE-KALIVLNNL-SVNAENQR
RLKVYMNQVCDDTITSRLNSSVQLAGLRLLTNMTVTNEYQHMLANSISDF-FRLFSAGNE
E-TK-LQVLKLLLNLAENPAMTRELLRAQ---VPSSLGSLFNKKENK----------EVI
LKLLRSICLHILEFV------------------------NILFC-FLYYY----------
------------------------------------------------------------
-------------------------------------------

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----------------------------------MRP--SK-------------------
------------------------------------------SA----------------
------------------------------------------------------------
---------------------------------------EG-------------------
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------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------TS-------------------------------
------------------EGQ-L----CGRS--------------TS---------Q-P-
-------------------------------------GVC--------------------
-----------FGNGN-------------------------------------K---DLT
DGSYD--------DVLNAAQLQKLLYLLESTEDPVIIERALITLGNNAAFSVNQ------
----------AIIRELGGIPIVGNKINHSNQSI------KE-KALNALNNL-SVNVENQI
KIKIYINQVCEDVFSGPLNSAVQLAGLRLLTNMTVTNDHQHMLHNYITDL-FQVLLTGNG
N-TK-VQVLKLLLNLSENPAMTEGLLHAQ---VDSSFLSLYDSHVAK----------EIL
LRVLTLFQNINNCLKIEGHLAV---------QPTFTE--GSLFFLLHGE--ECAQKIKAL
V-DHHDAEVKEKVLTIIPKI----------------------------------------
-------------------------------------------

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---------------------------------------MTGTKN--KTRAQAKTEKK-P
VTQAKAGAEREATGV------VRPV---------------------AKTRAKAKAKTGSK
-----TDAV---------------------------------------------------
------AEMKAV-------------SKNKVVAEVKEGALSEPKTLGRAM-----------
-----GDF----------------------------SSKAGNESTSSTCKNEAGIDAWFW
AGEE------------------------ATINSWFWNGEEAGN-SSST------------
---------KNDKP--------EIGAQVCA----E-------------------------
------------ELEPAAGADCKPRSGAEE------------------------------
EEEENVIGNWFWEGDDTSFDP-NPKPVSRIVKPQP---LYEINEKNRPKDWSEVTIWPNA
PAVTP---AVLGFRSQAPSEASPPS----YIVLASAEENACSLPGA------TACRPSRN
TRSCSQPIPECRFDSDPCI--------------------QTIDEIRRQIRIREVNGIKPF
ACPCKM------ECYMDSEEFEKLVSLLKSTTDPLIHKIARIAMGVHNVHPFAQ------
----------EFINEVGVVTLIESLLSFPSPEM-------RKKTVITL-NP-PSGDERQR
KIELHVKHMCKETVSFPLNSPGQQSGLKILGQLTTDFVHHYIVANYFSEL-FHLLSSGNC
K-TR-NLVLKLLLNMSENPTAARDMINMK---ALAALKLIFNQKEAK----------ANL
VSGVAIFINIKEHIRKGSIVVVD----------HLSY--NTLM-AIFREVKGIIETM---
------------------------------------------------------------
-------------------------------------------

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---------------------------------MGRTREAGCVAAG----------MVIG
AGACYCVYRLT--WGKDE-NEKLWD----EEEEEEEE--EEEKSC---------------
------------------------SDK------TE------KELKTNVGVGARGKPQDDS
-----------------------------KS------------KVEVNVGPENGPGVKKE
VHP----------------E--------SQSGGGLE---AKA------------------
-----------------KALFKT-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------L----------------------------------
----------------KEQARAKAGRGIRLPNIS--------------------------
---------------------------------------------RNRTLTSSLPCPGGR
GG---------GCHPGRTGSRA---------------------------------RNRTS
GKVKRKNRSKSNKAPA-T---------------------------AW----PVRKGKFSF
PYKID--------DILSAPDLQKVLNILERTNDPFTQEVALVTLGNNAAYSFNQ------
----------NAIRELGGVPIIAKLIKTRDPII------RE-KTYNALNNL-SVNSENQG
KIKTYISQVCDDTMVCRLDSAVQMAGLRLLTNMTVTNHYQHLLSYSFPDF-FALLFLGNH
F-TK-IQTMKLIINFTENPAMTRELVSCK---VPSELISLFNKEWDR----------EIL
LNILTLFENINDNIKSEGLASS---------RKEFSR--SSLFF-LFKESGVCVKKIKAL
A-SHKDLVVKVKVLKVLTKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
-------MTGAEIEPGTQAMPEKKSGEDVL--------G-----------MAEIENEVPL
VVRPKV--------------------------RIPAQIVTGARPKTKTKLMLGARSKM--
------------------------------------------------------------
------------------------------------------------E------SSIAV
GLHTKG--KTKVNLGSRFKDDV--------------N--------------AWTQKPFV-
-----AEPMSKTDGISQNNAKDSPLVSTDS--V-LVKTKSLSVGRELVNMDIDNFPRKKT
HSQVGFQSSFGLE-EVTN------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---IGSWCSPGPISK-QEASQNSNFKWVDRS-VNSWFCSGDEVNTKFHPRNRMKA-STRS
RHMAKQE-----V--DIMSRRKNKQEFYIVS-SSGSE-----------------------
-DESVKISWFWDKKKANSWYRSRSREEA-NDRSWFRSKKELYV------------ESSSG
SDCENNMKTLFWPGEEAKSRSKHRARNEANKRVRHNARREPSINVMSASL------DVIK
KESWFWNEEKD---------NSF-----LRSKTKKESRARALAK----------------
GE----AKTKARARAKREAMS-----EEEVFIGTWFWDTDEPSIMDGASIKSSPQVEDES
IFGTWFWTNEETNVETEASCKS-RPRVEEEPAGNSYFEAEEKKTSMEIEAEAISESVLAA
NDE-EAIVGSWFWASEE-AK---------------------------------LEPEEET
IFGPWFWGIDEPR-AESGVGMSSE-------------------------------SRLR-
-S-GEEVIDPWFWAGE-VNIEAGVGEE----------TRSESEEEAVFVSWFWSENQTHM
DSG------AEASCDIMPGTEEEEEEDEPIFGSWFWAGIDACVEAEVNNKSMLEDEDE-A
IISSWFGAREEASVKYGAGGRYKFMAEAEDTDNRSCFWAEEEPCVNPSNRGSWKSRPEEE
-----EDTVDSWFWSRKYSRPEAAVG------------------------SWLWAAGEGS
IDHETGEEAKLPTEEETMIKSWFWKEE-EAIIDATDRKEFSSVAEEEDIIGSWFWAGEED
RLEAPAEAREENRLALEDE-PMVGSWFWAKEEAI-REAEFCDKYSSNTNEEEVVVGSWFW
EEASLEA------------VETG----DILVGSCFWTEE-AIVE----------------
------------------------------------------------------------
-----------------------FMPENEEGALFGSCPESKEEVNNSTGNETNYESGTLA
DEDEDIVGSWFWAGDEAHFES-NPTPVFRAICKPRYSIEQEPDPSRRPQTWEEVTVQFKP
-GPW----SRIGFSSLSPSRFPKEA-ASLFFEMFGGKPKHVELKQES-------------
-LHQ--PEPEFPFQYDPSY--------------------RSVREIREHLRARESAEPENW
SCSCIQ-----CELRIGSEEFEELLLLMDKIRDPFIHEISKIAMGMRSASQFTR------
----------DFIRDSGIVSLIETLLNYPSSGV------RT-RFLENMIRM-APPYPNLN
MIQTYVCQVCEETLSYGIDSLEQLSGLRMIEHLTITTDYHELVANYMPGF-LCLLATGNT
A-TR-FHILKILLNLSENLVMTKDLLSAG---AMSEFMGIFNREETN----------DNI
QIVLEMFENISNNIKNDAV-FA---------DDDINL--DPLI-SAFHEAEKFAKELQRK
INHQNDP-----------------------------------------------------
-------------------------------------------

------------------------------------------------------------
--------------------------------------------MGRIQEVGWVTAGLVI
CTGTCYYIYKVTKGRNQSVSRLAKNGSRV-KMETVVG----VQNQTLAISEAM----IET
RPKTKTGAEIGAGGGPGAEVDTKVTAIVRSKANSQ----AKVMAGEEADIQSE-------
AKVVSGTLVMTEAVTLIEAE--AEAREVALKEAVTQTDAEPGRLVKKEAVTQTK-AKSWA
LDAKDEAKKEAMTQTKAEARILAEKETEINRVMVTQSETLAVTRE----VAKMEAMNKTG
IVAETKARALEETVSVAKTQSEARPGATVDARGNPNGMSREVAGVDMKSYAQSQAVAKIQ
GDDMPGAGVEDKGNCK---------------------------TMSRAGSGADMRASAQS
QIVGKTQAEATPRARVDAWGNVNAMCEVGAGADMRASE------------VTSSAK-VDG
RGNTNVILKAMTAADTWGAIHPQAVASAQAETIPDARIKGRSNPNAMAKAGARANSRANS
QAEALPDARDKRRDNPNIMAKAEAGTDMLSCT-HPQPVANVQADSLSDGQIKAKGNANTM
SKEGAGTDTRAQPQVMAQSLGEALPNIKGKARGKAKAKCKAGIGPDMKTCVQPQAGAKTQ
VEALPDCKVDGRGDLNAISRAGAKADQKACGPPQVVISSQGEALPGSKNRVKGNLRAVPT
AETGAGTTGFAQV-----------------------------------------VANSEG
EALPGTKNKVKGHPNAVSKAGS--------------------------------------
--GADTIGFAQPQVMANSQGEALPATKNKVKCNSSAVSKAGAGTDT--------------
--------------------------TGSAQPQTVAHSQGEALPGAKNKVKGNRNA----
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------VPKVGAGADT---
-------------------------------------TGSAQPQAVSNSQSEALLGAKNK
VK----------------------------------------GDLDAVSKAEAGAGTTGS
AQPQAVATSQGEALLGAKNKVKGNPNALSKAE-----TGMSTVGSAQPQAMAKSQNEALL
GARNKVKGNSNAMSKAESGAGTMGSAQPQVVANSQGEALPGAKNKVRGS--PNAVSKAEA
GANIMGSAQPQAVTNSQSENLLGARSKVRGNLNAVPKSGAGAGKRHSAQSQVVASSQ---
-------------------------------------GETLPGARDKAMTSSEAEATAEH
EVYAKPH--AETVPPSESEGGSSTEACRKTQPNIHDYYWNGIGVEDWIAAERWIKFRFQA
MDGDWENSVSWADDENEAGIGSWSGA-NDK--ADIVGSWAVAC----DEASVKSWARARA
ENEVGIGSWAGAG-AQASGGLWVGGQSSEGSWAGDK------------ASGMSWTGAENQ
ACGGSWTISGNQAIGELWAGGQASEGSWPGGQASGVSWAGEGAIGGSWTG--------AE
NQDSGASWAG------------------------AEAGNMYSVGYWAGAVDQTNG-LSW-
-----------AGSGDQSGNGSKPQFEDQASEKGSWAGPVGQASGGCRLGPEDQSSGGSW
ADIADQASGGSRLGPVDQSGGGSWA-----------------------------------
-------------KTGDQSGGGSKPRFENQVSEGG-SWVGAIGQAGGGSKLGPEDQSSGR
SWANSGDQINEGFLVAAVDQASGGSWAGAGAGAGDQASGGAKPIFEDQASGGGSW-PDAG
DQTSRGSRLGPSEQSSGDSWAGTGDQASG------------WF-------------CIYT
G---SQTNGGGSWGGAGGQDVGVSMPGSTDQSSGGSWAGTGSQVSGGSWAGAGAVDQAGG
CSKSGFEDQTIGGGFWISAGDQASGGSRPGPEDQS--SGGCSWGVAGGQLI---------
------------------------------------GGSRPGPAEQSSGGSWAGTG---N
QASGMSWVGPR--DQ-AGGCSKPEFEDQ-ACGGGSWAGSGDQGSGEPWVVSRPENE----
---ASGE-----------------------------------------------------
--------------------------------SRLEPEGQASGRFQVSFEVEANEGFWFG
PGAEACIGTWCWTGEEAIILPRLDIKEKASIESKSGAGEEAIISSRSEAE------NKTV
IGSWVRPQEAA--------YIGF----CVGAEAGAEAGAEAE------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------A----
--GAEAEAGAEAGVEA-----------------------------GAEGGAEARMGFWSW
DGHA------------------------TTIGSRLGAGEEAGV-----------------
---ASWTLAWD------V-DEDELSRESSP-DI-EEIS----------------------
-LRSLFWAESENSNEFRSK--------SERD--VNFEFGTGDKA-CIKDNFEA-------
-ADGVDISSWFCADYENRSED-KSAPEAKDKKSAE-S----------RGTYPSM-VPGAG
MGLW----DGAMIWSETK--FP------------HQ--IAANFLAEG----D-----GR-
KQ-I-----------------------------------RP------------EEKFRHW
SCRCKR------EANMDPQDLEKLICMIEMTEDPSVHEIANNALYNSADYPYSH------
----------EVARNVGGISVIESLLSNPHPSV------RQ-RALNALNNI-SVAAENHR
KVKTYLNQVCEDTVTYPLNSNVQLAGLRLIRHLTITSEYQHMVTNYISEF-LRLLTLGSG
E-TK-DHVLGMLLNFSKNPSMTKDLLIAN---APTSLINIFSKKETK----------ENI
LNALSLFENINYHFKRRAKAFTQ--------DK-FSE--NSLY-FLFQRPKACAKKLRAL
AAECNDPEVKERVELLISKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
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-------------MICRLDSAVQMAGLRLLTNMTVTNHYQHLLSYSFPDF-FALLFLGNH
F-TK-IQTMKLIINFTENPAMTRELVSCK---VPSELISLFNKEWDR----------EIL
LNILTLFENINDNIKSEGLASS---------RKEFSR--SSLFF-LFKESGVCVKKIRAL
A-SHKDLVVKVKVLKVLTKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------MTRADIKPTAQAKPERKAREEVG--------G-----------GAERENEVPL
VVRPKV--------------------------RTQVQVMLGARPKSDAMVVGGVKPKA--
------------------------------------------------------------
------------------------------------------------E------DMVVG
VVHPKN--EAKLIPGARPIDKA--------------H--------------SWAQTEFD-
-----GKAMLKTEGVSQINAIAWPTVSTES--GSVAESKILSLDREPISVDIESFPSTKV
KFQSGIQPLFGSE--KTS------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---VGSWWYPRPTSK-EEFSHKCEHR----EDLNSWFWSGEEVSTNFHPRGRVKG-SPRS
RSMAKEE---------AMSRLNTNQEFYILS-SSSSE-----------------------
-DESNKTSWFWTREKTNIWS--RPKEET-NNRSRFRSKKELY-------------ESSSG
SEYEDNVKSWFWAREEAKSRSKPRARKGANVRARHRAKQEDYIDFVSGSI------NVVK
KEYWIWPGEKA---------HNL-----PRPKSKKEARARIIAK----------------
EK----PKPKARARSKQEARS-----EEEFLIGTWFWATEGSNVVGGDSVKYNSQVEDES
IVGCWFWTERWPD------SKS-RLCTEEESIRNSMFVSG-EKTIMVTGVETNSKSMVVC
DKE-KVIADSCFWASEE-TN---------------------------------LEAEEET
IFEPWFWVSIEAS-VESDVRANCA-------------------------------SRPR-
-SEEEEVIGPWFWDGK-VNTEAEFVEE----------ANPEDKEETIFGSWFWAGNQAQI
DSG------SKVSCDTMPGAE------EPIIGSWFWEGVEACVGTEVSNKSSLKDKEE-V
IISSWFGTTEEVSMKYGTGARCKFMARAEDTNNESCFLDEDDPCMYTANGSSWKSRPEEE
-----TGTVDSSFWSEI-PSPETIIG------------------------PWLWATEEVS
IDDRTGEEAKPLMEEETMITSWFWKGD-KTIREATD-EESRPNAKEEDIIGSWFWAGDED
RLKIAAEARKEDRLAEA-------------------------------EEEVSTVGSWFW
AEEEA-SLEAGVSFESMPVTEEE----EVIFGSWFWAEEDDSIEIGHQATGESRSRTEEE
ILFRSWFCAAKE-----ASIEAEKCCVSNSEDD--EII----------------------
-FESWFWSGKKDINETGTVVTCESRPENEEGIVVGAGYE------------TSQETRTVA
EEDEAIVGSWFWAGDEAHFES-NPSPVFRAICSSGCSFEQEPDASRGPQSWEEVTVLFKP
-GPW----GRVGFPSPIPFRFPKEA-ASLFSEMFRGKPKHMELTPEW----E--EQESLL
QPDQ--PEPEFPFQYDPSY--------------------RSVREIQEHLKARESAEPESW
SCSCIQ-----CELKIGSEEFEELLLLMDKIQDPFIHEISEITMGLRSASQFTR------
----------DFIRDSGVVSLIETLLNYPSSRV------RT-SFLENMIRL-APPYPNLN
MIQTYVCQVCEETLAYSLDSPEQLSGIRMVRHLTTTTDYHTLVAKYMSGF-LSLLAMGNT
K-TR-FHVLKMLMNLFENPVMTKELLHAK---AMSEFMGLCNRKETN----------DNI
QV-LAMFENIDNNIKKETVLFT---------DDDFSL--EPLI-SAFHEVEEFAKELQGK
TDDQKDP-----------------------------------------------------
-------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
---------------------------------MGGARAAAWVAAG----------LALG
AGAGFCVYRLA--RGRRR-S----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------KRG------------LRSSG---------------------
--------------SA-------------------------------------E---DLT
SGSYD--------NVLNAEQLQKLLYLLESTEDPIITERALVTVGNSAAFSTNQ------
----------AIIRELGGIPVVANKINSPNHSI------KE-KALNALNNL-SVNVENQI
KIKTFISQVCEDVLSGPLDSAVQLAGLRLLTNMMVTDEHQHMLSGYIADL-FRVLLTGNG
T-TK-VQVLKLLVNLSENPAMTEGLLSAQ---VGSPFLSLVDGCVAQ----------EIL
LRVLTLFQNINNCLRAGGRPAG---------QPPFPN--GSLFSLLYGE--ECVQKMQAL
V-YHHDVDVREKAVTITSKF----------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
---------------------------------MGYARKVGWVTAG----------LVIG
AGACYCIYRLT--RGRKQNKEK-MA----EGGPGDVD--DAG----------------DC
---------------------------------------------------------MGA
--RYNDWSDDD-------------------------------------------------
DDS----------------N--------E-------------------------------
------------------------------------------------------------
-SKSIVWYPPT-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------RA----RRAVQKRAS
PNSDD--------TILSPQELQKVLCLVEMSEKPYILEAALIALGNNAAYAFNR------
----------DIIRDLGGLPIVAKILNTRDPIV------KE-KALIVLNNL-SVNTENQR
RLKIYMNQVCDDTVTSRLNSSVQLAGLRLLTNMTVTNEYQHMLANSISDF-VRLFSAGNE
E-TK-LQVLKLLLNLAENPAMARDLFRAQ---VPSSLGSLFNKKENK----------EII
LKLLIIFENIIDNFKWDENELT---------QNQFGD--GSLFV-FLKEFQVCADKVLGI
E-SHHDFLVKVKVGKFMAKLTEHMFPKGQK------------------------------
-------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
---------------------------------MSRVRDAGCVAAG----------IVIG
AGAWYCVFKYS--RGRDQ-K-KRLV----KAKPKA--VARTGAKARAGLRAGFTIDLRPG
FGPPAPVLAGAQDR-DQDGDSALNNGGAEAMVPAA------ASAEAQSGAGSQAQEA---
---------ESEVGTAAPSAMAPPPGEAQAP------------GATEAPTMPEALTMPEA
PTM----------------P--------EARTMPEAPTIPGAPKLA-ETP-----S----
------------------------------------------------------------
---------------------------------------------------------ADE
APAVA-----------PPKAT---E-----------------------------------
------------------------------------------------------------
-------------------------SVRVMEAPT------------AAAPT---------
---------EVAEAPE--------------------------------------------
-VAAPAEVMQTPGAAAS------------------------------T------QA----
---AE-----------PTGPT-----------------E-PP------------------
----------------------GTSRSSR-------------------------------
-----------IAPVPGTAATKRATPGAHTGAIPKAGS--ATGA---VPKGGA-------
-----------KGGTKSRAGG-K----GKGK-------------K-NKVEVDELGLGFRP
GD---------GAAVAAAASAN------------GGQAFLAEIPDS-----EEGESGWTD
TESDSDSEPETQRRGRG----------------------------KR----PVHMQKRPF
PYEID--------EILGARDLRKVLTLLQKTDDPFIQQVALLTLSNNANYSCNQ------
----------DTIRKLGGLPIIANMINKTDPHI------KE-KALMVMNNL-SENYENQG
RLQVYMNKVMDDIMASNLNSAVQVVGLKFLTNMTITNDYQHLLVNSIANF-FRLLSQGGG
K-IK-VEILKILSNFAENPDMLRKLLSTQ---VPASFSSLYNSYVES----------EIL
INALTLFEIIYDNLRAEVFN-----------YREFNK--GSLFF-LCTASGVCVKKIRAL
A-NHHDLLVKVKVIKLVDKF----------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
-------MTGTEFELYTEDKHEKKSEEKVV--------N-----------VAETESEIPL
VVRPKV--------------------------RTQAQIMTGARPKTKTKVVPGTWPKT--
------------------------------------------------------------
------------------------------------------------E------ARAVG
SVYTKH--KIKTMRESRSKDVA--------------Q--------------ARALSEFG-
-----PTSILKTEQDSQINAIISPGVSSDS--GLVSNTKCLFMDRELIKTNNESFPGNTV
HCQVRFQSSFGSR-KVTD------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---SEPWSFPRPTSK-QEPSQNSDFNWVDKS-VNSWLWSQEEVNGSFHPQNKIKS-GTRS
RYISKQE-----E--TNYSRHKNKQDLYIVSSSSGSE-----------------------
-DESVKTSWPCGKQKTNSLF--RSREEV--SRSWLRSEKEVNI------------EFSPG
SECENAMKSWFWDREETKCSTLPRTRKETNERARYSPKQETCVDTMSEST------DIIQ
KKPWFGPEGKG--------KNTF-----LRCNTKK-TRAQTMEK----------------
EE----T----RTSTKREERT-----QEETFVETWFWATDESSLMDVPNIKSSPQLEDES
IIGSWFWNEQEVSMEKGPSSKS-RLGVE-ELIDNSYLGDG-EKTSIEIGAEATSHSILSS
NDE-EVIVGSWFWAGEE-VN---------------------------------PEPKEET
IFGAWFWSIDEAS-VESDVGINCE-------------------------------SKPR-
-S-SEEVIGPWLWAGE-VSSGAGVGEE----------FSQGSEEETVYLSWFWSENQTSI
DSA------TEASSDVPGAEE----EEDPMFGSWFWSKVDACEEATVNSKSNLEDEE--A
IISSSFVAREEATVKYGTGARCKFMVEAEDT--KSCFWAEEEPCMYRASRRNWKFRPEEE
-----EDTADSRFCSRKYTQPEALVG------------------------SWLWAAEVGS
TDYEIRQEAMLPTEEMTMTKSQFWKEDKDATVEATDRKESWPESEEEDIIGSWFWSEEED
RLETQREGREESGLGVE--ESVFRSW--GEQEAI-TESVFSSKYSSKADAEEVIVGSWFW
EQETSLEVVTADTFESKTSTEDE----EIIVGSWFWPKE-PDREAESQAVEETRSKTE-K
KILESC-CDK-------VNVEAGMCYVSKPEYD-EEMI----------------------
-VESWFWSTDK---ETGTVATCECKSQDD--EVVETWSRATNEVNNRPGDGTNCESRT-V
-DDENIVGSWFWVGDESHFES-NPSPVFRATCEPWGSVKQEPDLSHRPQSWEEVSFEFKP
-GPW----GRVGFPSLGSFRFPREA-APLFSELFGE-NRHVEL-----------NQESFR
H-----VEPEFSFQYDPSY--------------------RSVREVREHLRAKENAEAETW
SCTCIQ-----CELKIGSEEFEELLLLMDKIQDPFIHEISKIAMGMRSSSQFTR------
----------DFIRESGVVSLIETLLNYPSSRD------KT-RFLKEMILM-APPYPNLN
MIQTYVCQVCEETLAYSVDSPEQLSGLRMIRYLTTTTDYHTLVANYMSGF-LTLLATGKN
K-TR-FHVLEMLLNLSENFTMIKVLLSTE---AVSKFMGLFYREETN----------DNI
QIVLAIFENIGKNIRKETVFID--D-------DDFSL--EPLI-SMFREVEKFAKQLQSK
IDNQTDP-----------------------------------------------------
-------------------------------------------

------------------------------------------------------------
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---------------------------------MGYARKVGWVTAG----------LVIG
AGACYCIYRLA--RGRKQTKEK-MA----ESGSADVD--DAG----------------DC
---------------------------------------------------------SGA
--RYNDWSDDD-------------------------------------------------
DDS----------------N--------E-------------------------------
------------------------------------------------------------
-SKSIVWYPPWAR-----------------------------------------------
------------------------------------IG----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------T--------------------------------
-----------EAGTRARARA---------------------------------------
------------------------------------------------------------
-------------RARAT---------------------------RA----RRAVQKRAS
PNSDD--------TVLSPQELQKVLCLVEMSEKPYILEAALIALGNNAAYAFNR------
----------DIIRDLGGLPIVAKILNTRDPIV------KE-KALIVLNNL-SVNAENQR
RLKIYMNQVCDDTVTSRLNSSVQLAGLRLLTNMTVTNEYQHILANSISDF-FRLFSAGNE
E-TK-LQVLKLLLNLAENPAMARELLRAQ---VPPSLGSLFSKKENK----------EVI
LKLLMVVENISDNFQWEENESA---------QNHFSE--DSFFS-FLKEFQVCADKVLGI
E-SHHDFPVKVKVGKVAAKLTERMFPQSQE------------------------------
-------------------------------------------

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------------------------------------------------------------
-----------------------MIGSTTKAKGREESGASLKPG--------SKSL----
------ANAKEKAKSQTKKVV-----EAKPKEELG----TQAEARDEAMARTQTVTHTEP
--ETMTWKVKKK------------------------------------------------
------------------------------------------------------------
-----------KDKTNTRVKDQTKTELRA-EPGLVPHTKADDLPMSVV--ITVTKSEIRV
D-----------------------------------------------------------
-------TGIETSIKYSSKAS-----DKGSMKHISEI-----------------------
--------KKETLVRSG----------A--------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------GDKASIVI-----------------------------NTTDEDEEYVCSWFW
TGEE------------------------PSVGSWFWPKEETPLQV---------------
-----YQPPPK---------------------V-EEEP----------------------
------------------------------------------------------------
----------------------EP-TD-----------------------NFDFTLKRKA
-AAW----ARG--RFIVLVPVE------------EF--EQS-LPP---------EGNWTL
VATLIET--------PLGIRPLTKIPPFEGPYFQTLAE------IKNQIREREKYGPNPK
TCRCKS-----RTFSLEPIEFDKLVALLKLTRDPFIHEIATMIMGISPAYPFTQ------
----------DIVHDVGITVMIENFVNNPNAKN------HS-RTVNVS-AS-ADTSEEAK
ENEAHVDKVCRDILSCPLNCSVQVEELKLLASLSMKFENHHVIINYVRHF-ITLLSKGSV
K-LK-FQILRVILYLSKNQANTRELISAE---VLSSLVALFHKNESK----------ANV
LHIINIFENINFQFKKRAKLFTK--------EM-FTK--SELI-SIFQEAKQFDLKLQDL
I-DHSDPEVRDKIIRLILKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
-------MTGAEIEPSVQAKPEKKAGEEV--------IA-----------GAERENDVPL
VVRPKV--------------------------RTQ--ATTGARPKTETKSVPGARPKTDA
------QAMSGA------------RPKT----------------------------EAQV
MGGARSKT----------------------------EAQGMAGARPKTD------ARAVG
GARPKT--DAKAIPGTRPKDEA--------------Q--------------AWSQSEFG-
-----TEAVSQAEGVSQTNAVAWPMATAES--GSVNKSKGLSMDRELVDVDAETFPGTQ-
-GQKGIQPWFRPG-EETN------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---MGSWCYSRPRAR-EEASNESGFWSADETSTVSSFWAGEETSIRSWPREES---NTRS
RHRAKHQ-----T--NPRSRPRSKQEAYVDS-WSGSE-----------------------
-DEAGNLFSFWAGENTSNLF----------------------------------------
---------------------RPRVREEANIRSKLRTNREDC--FESESE------DEFY
KQSWVLPGEEA---------NSR-----FRCRDKEDPNTALKPR----------------
AQ----KDV-DGDRVKQEPRF-----EEEVIVGSWFWAEKEA------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------SL
EGG------ASAICESEPGTE-----EGAI------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------GGSTYWAEEKS
GLGA--------------------------------------------------------
-----------------------------------------------VAREEAKPES---
------------------------------------------------------------
------------------------------------------------------------
-EEEAIFGSWFWDRDEACFDL-NPCPVYKVSDRFRDAA-EELNASSRPQTWEEVTVEFKP
-GLF----HRVGFRSTSPFRIPEEAS-----EMLEAKPKNMELSPEG----E--EQESLL
QPNQ--PSPEFTFQYDPSY--------------------RSVREIREHLRARESAESEGW
SCSCIQ-----CELKIGSEEFEELLLLMDKIRDPFIHEISKIAMGMRSASQFTR------
----------DFIRDSGVVSLIETLLNYPSSRV------RT-SFLENMIHM-APPYPNLN
MIETFICQVCEETLAHSVDSLEQLTGIRMLRHLTMTIDYHTLIANYMSGF-LSLLTTANA
R-TK-FHILKMLLNLSENPAVAKKLFSAK---ALSIFVGLFNIEETN----------DNI
QIVIKMFQNISNIIKSGKMSLID---------DDFSL--EPLI-SAFREFEELAKQLQAQ
IDNQNDPEVGQQS-----------------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
---------------------------------MGYARKVGWVTAG----------LVIG
AGACYCIYRLT--RGRKQNKEK-MA----EGGSGDVE--DAG----------------DC
---------------------------------------------------------AGA
--RYNDWSDDD-------------------------------------------------
DDS----------------S--------D-------------------------------
------------------------------------------------------------
-SKSIVWYPPWAR-----------------------------------------------
------------------------------------IG----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------T--------------------------------
-----------EAGTRARARA---------------------------------------
------------------------------------------------------------
-------------RARAT---------------------------RA----RRAVQKRAS
PNSDD--------TVLSPQELQKVLCLVEMSEKPYILEAALIALGNNAAYAFNR------
----------DIIRDLGGLPIVAKILNTRDPIV------KE-KALIVLNNL-SVNAENQR
RLKIYMNQVCDDTITSRLNSSVQLAGLRLLTNMTVTNEYQHILANSISDF-FRLFSAGNE
E-TK-LQVLKLLLNLAENPAMSRELLRAQ---VPSSLGSLFNKKENK----------EVI
LKLLVVFENLNDNFRWEENEPT---------QNQFDE--GSLFF-FLKEFQVCADKVLGI
E-SHHDFLVKVKVGKFMAKLAEHMFPKIQE------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
---------------------------------MGGARDVGWVAAG----------LVLG
AGACYCIYKLT--RGQRQ-GGR---------GFRLRA--SR-------------------
------------------------------------------SAE---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------DLT
NGSHD--------DVLSGDQLQKLLYLLESTDDPVIIERALVTLGNNAAFSANQ------
----------VIIRELGGIPVIGSKINSPNHSI------KE-KALNALNNL-SVNVENQV
KIKVYINQVCKDVLSGPLDSAVQLAGLRLLTNMTVTNDHQHMLRSYITDL-FHVLLTGNG
S-TK-VQVLKLLVNLSENPAMADGLLSAQ---VDSSFLSLYDSHVAK----------EIL
LRVLTFSQNISNCLKKEGCLAV---------QPAFPK--GSLFFLLYGE--ECAQKMRAL
A-EHHDADVKEKVTVLPRF-----------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
---------------------------------MGRTREAGCVAAG----------VVIG
AGACYCVYRLA--WGRDE-NEKIWD----EDEESTDT--SE-------------------
-----------------------------TGVETV------KGAKTNVGAGSGAKLQGDS
-----------------------------KV------------KPEVSLGLEDCPGVKEK
AHS----------------G--------SHSGGGLE---AKA------------------
-----------------KALFNT-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------L----------------------------------
----------------KEQASAKAGKGARVGTIS--------------------------
---------------------------------------------GNRTLAPSLPCPGGR
GG---------GCHPTRSGSRA---------------------------------GSRAS
GKSKGKARSKSTRAPA-T---------------------------TW----PVRRGKFNF
PYKID--------DILSAPDLQKVLNILERTNDPFIQEVALVTLGNNAAYSFNQ------
----------NAIRELGGVPIIAKLIKTKDPII------RE-KTYNALNNL-SVNAENQG
KIKTYISQVCDDTMVCRLDSAVQMAGLRLLTNMTVTNHYQHLLSYSFPDF-FALLFLGNH
F-TK-IQTMKLIINFTENPAMTRELVSCK---VPSELISLFNKEWDR----------EIL
LNILTLFENINDNIKNEGLASS---------RKEFSR--SSLFF-LFKESGVCVKKIKAL
A-NHNDLVVKVKVLKVLTKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
---------------------------------MSRVRDAGCVAAG----------IVIG
AGAWYCVYKYT--RGRDQ-KKKRLA----KPKNRA--AAGTGARAKAGLRAGFTIDLGPG
FSPPAPVHTGAEDK-AQDEASALDTAGAEPVVPAM------SSPKAQSGAGNQVQETDGA
--GVGPKT-ESVVVAAAASSVAPPPMVAEAP------------TAAEAPAVAEAPSTAEA
SRA----------------S--------APPRAAVT-PGAAAPPGAAAPPGAAAPP----
-----------------RAAVTPG--------------AAAAPPRAA-------------
VTPGAAAAPPRAXA----------------------------------------TPGAVA
PPGAT----------APPGAT---APPRA-------------------------------
-------------------------------------------AAPP----RAAAPPGAT
APP------------------GATAPPRATAPPSAAAPPRAAASPGAAATHGAVAAHGGA
TAT----SGAAAVPPRAAAPPR---AAVS------PGTAAPPRAAASAVVAAASEAVVAP
GVAAPTEVAQTSGMAAP------------------------------AEVAESPVPTL-F
AGSAA-----------PTGAA-----------------E-AP------------------
----------------------GTSGSPR-------------------------------
-----------TA-----VAGKKATPGAHTGAIPKAAS--ATGA---VPKGGA-------
-----------KGGTRSRTGG-K----G--KS------------KKSKVEVDELGMGFRP
GD---------GAAAAAAASAN------------GGEAFLAEVPDS-----EEGESGWTD
TESDSDSEPETQRRGRG----------------------------KK----PVPMQKRPF
PYEID--------EILGVRDLRKVLALLQKSDDPFIQQVALLTLSNNANYSCNQ------
----------ETIRKLGGLPIIANMINKTDPHI------KE-KALMAMNNL-SENYENQG
RLQVYMNKVMDDIMASNLNSAVQVVGLKFLTNMTITNDYQHLLVNSIANF-FRLLSQGGG
K-IK-VEILKILSNFAENPDMLKKLLSTQ---VPSSFSSLYNSYVES----------EIL
INALTLFEIIYDNLRAEVFN-----------YREFNK--GSLFY-LCTTSGVCVKKIRAL
A-NHHDLLVKVKVIKLVNKF----------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
---------------------------------MGYARKVGWVTAD----------LVIG
AGACYCVYRLT--RGRKH-KKK-MA----EGGSGHVD--DAG----------------DC
---------------------------------------------------------SGA
--RYNDWSDDD-------------------------------------------------
DES----------------N--------E-------------------------------
------------------------------------------------------------
-SKSIVWYPPWAW-----------------------------------------------
------------------------------------IG----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------T--------------------------------
-----------EAGTRGRA-----------------------------------------
------------------------------------------------------------
-----------------T---------------------------QV----RRAVRKQGS
PNSDD--------TVLSPQELQKFLCLVEVSKKPYIFEAALIVLGNNAAYTFNR------
----------DIICDLGGLSIVAKILNTQDPIV------KE-KASIVLNNL-SVNAENQH
RLKVYMNQVCDDTITSCLNSSVQL--------------YQHMLANSISDF-FRLFSAGNE
G-TK-LQVLKLLLNLAENPAMTRELLRAQ---VLSSLGSVFNKKEDK----------EVI
LKLLVIFENINDNFKWEENEPT---------QNQFG-----------KEFQVCADKVLGI
E-SHHDFLVKVKVGKFVAKLAEHISYLRSDLPN-MAK-----------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
---------------------------------MGGPGGAGWVAAG----------LLLR
AGACCCIYRLT--RGRRR-DDG---------ELGMRP--SK-------------------
------------------------------------------SAE---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------DLT
DGSYD--------NVLNAAQLQKLLYLLESTEDPVIIERALITLGNNAAFSVNQ------
----------AIIRELGGIPIVGNKINHSNQSI------KE-KALNALNNL-SVNVENQI
KIKIYINQVCEDVFSGPLNSAVQLAGLRLLTNMTVTNDHQHMLHSYITDL-FQVLLTGNG
N-TN-VQVLKLLLNLSENPAMTEGLLHAQ---VDSSFLSLYDSHVAK----------EIL
--------NINNCLKIEGHLAV---------QPTFTE--GSLFFLLHGE--ECAQKIKAL
V-NHHDAEVKEKILTIIPKI----------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MSRVRDAGCVAAG----------IVIG
AGAWYCVYKYT--RGRDQ-KKKRLT----KPKNRA--VAGTGARARTGLRAGFTIDLGPG
FGPPTPVRARAEDG-PQDEASALDTAKAEAVAPAA------PSAEAHGEAGIQVQEAEGG
--GVMPKA-ESAVGAAAAPVVTPPPGVAEAP------------AAAEAPPVAGIPKVAEV
PSV----------------A--------EVPRAA-APAGTAAPTQV-AA-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------PTQAAEPPG------------VAAPT---------
---------EAA---EAP------------------------------------R-----
-VVPPTEVAEVAVPA---------------------------------------------
---VP-----------A-GAA-----------------E-AP------------------
----------------------GTSGSPK-------------------------------
-----------TAA-----AAKKATPGAHTGAIPKAGP--ATGA---VPKGGA-------
-----------KGGTKSRTGG-K----GKGK-------------R-NKVEVDELGLGFRP
GD---------GAAAAAAASAN------------GGQAFLAEVPDS-----EEGESGWTD
TESDSDSEPETQRRGKG----------------------------KR----PVAMQKRPF
PYEID--------EILGVRDLRKVLALLQKSDDPFIQQVALLTLSNNANYSCNQ------
----------ETIRKLGGLPIIANMINKTDPHI------KE-KALMAMNNL-SENYENQG
RLQVYMNKVMDDIMASNLNSAVQVVGLKFLTNMTITNDYQHLLVNSIANF-FRLLSQGGG
K-IK-VEILKILSNFAENPDMLKKLLSTQ---VPSSFSSLYNSYVES----------EIL
INALTLFEIIYDNLRAEVFN-----------YREFNK--GSLFY-LCTTSGVCVKKIRAL
A-NHHDLLVKVKVIKLVNKF----------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------MIGSKTKRKAREESGASSKPG--------TNSP----
------ANAKGKAKNQTTKAV-----KAEPKEEWG----NQAEARDEAVARTQPAISTEP
--KTVTWKVKKK------------------------------------------------
------------------------------------------------------------
-----------KDKTNARVMAQAKTELPA-GPALVPHTKSDALPTSVV--ITVTKSEVKI
D-----------------------------------------------------------
-------TGIEASLKGAAKAT-----DKRSIKQKPEI-----------------------
--------KKEVCVKSR----------AGDKA-------------KE---VCVKSSAG--
------------------------D--------------------------------K--
-AKEVC-------------------------------VKSRAGD--KAK-----------
EVCVKSRAGDKASIVI-----------------------------NTTDEDEDYVCSWFW
TGEE------------------------PSVGSWFWPKEENPLQV---------------
-----YQPPPK---------------------V-EEEP----------------------
------------------------------------------------------------
----------------------EP-PD-----------------------TFDYALKKKA
-AAW----LRG--RFIVLVPIE------------EP--QPS-LPP---------DGNWTL
VATLIET--------PLGIRPLTKIPPYGGPYFQTLAD------LKNQIREKEKYGPNPN
TCRCKS-----RTFSLEPVDFDKLVALLKLTRDPFIHEIATMIMGISPAYPFTQ------
----------DIVHDVGITVMIENFVNNPNAKK------YP-RTLNIN-AN-PDAPEEVK
ETEAHVNKVCRDILCCPLNCSVQVEELKLLVSLSVKFDYHHVVIYYVRYF-ISLLNKGSV
K-IK-FQILRVLLCLSKNQANTRELISAE---VMSSLVALFHKNESK----------ANI
LHIIEIFENINFQFKKRAKLFTK--------EM-FTK--SELI-SIFREAKEFDQKLQDL
T-DHSDPDVRDKVIRLILKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
-----------IVQVCLLDPTVQMAGLRLLTNMTVTNHYHHLFSYSFQDF-LALLCLGNH
F-TK-IQIMKLIINFTENPAMTKE-VSCI---VSSECISLFNIEWNK----------EIL
LNILTLFENINNNIKNEGLLSS---------RIEFR------------KSEVCVKKIKAL
A-NHNDLVVEVKVLKVLTKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MGGARDVGWVAAG----------LVLG
AGACYCIYRLT--RDRRR-GCR---------GRRLRP--SR-------------------
------------------------------------------SAE---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------DLT
DGSHD--------EVLNAEQLEKLLYLLESTEDPVIIEKALVTLGNNAAFSANQ------
----------AIIRELGGIPIVGNKINSPNDSI------KE-KALNALNNL-SVNVENQI
KIKIYVNQVCEDVISDTPNSAVQLAGLRLLTNMTVTNDHQHMLSNYITDL-FHLLLSGNG
S-TK-VQVLKLLLNLSENPAMTEGLLNAQ---VDPSFLSLYDGQMAK----------EIL
LRVLTLFQNIKNCLQMEGHGAN---------QPSFAK--GSLFFLLYGE--ECAQKMRAL
V-YHHDEDVKEKVVTIIPKF----------------------------------------
-------------------------------------------

------------------------------------------------------------
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-----------------------------------------------MGRARE--MGWMA
AGLM----IGAGACYCVYKLTI------------GR--DDSDKLEE------EDEEEWDD
DQELDEEEPEIWFDFTTMARPWSEDEDWTEPGAPGGTEDRHSGGGKANRA--HPIKQRPF
PYEHK--------NTWSAQTFKSVSCIIDLSKCPSIQGKKLFAEPKDAVFSLSH------
----------NIRSHLANLSICGNTLPTPHPTV------RE-EALCAPGNL-NASTENQG
QIKMFINEVCQETVPRSCNSFLQQAGLNLLISMTVINN---MLAKSVSDLKFPLIPERSG
C-AK-VQVLEPLMGLSEKPLLAGELLGAQ---MLLSFMSLFIRSANR----------EVL
LETLTP------------------------------------------------------
------------------------------------------------------------
-------------------------------------------

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-------MTGAEIESAAQVKPEKKPGEEAV--------G-----------GAERENEVPL
VVRPKV--------------------------RTQAQIMTGTKTKNKSKVMPGGSTKV--
------------------------------------------------------------
------------------------------------------------E------TSAVG
GARPKN--KAKAIPVSQFKDEA--------------Q--------------MWAQTEFG-
-----AERMSKTERNSQTN-IASPLVGTDS--VLVAKTKFLCEDGELVNTDTESFPGRKA
HYQAEFQPSFRSE-EETN------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---MGSWCCSRSTSK-QEASPNSDFQWVEKSSVSSLFWNGDEVTERCHPRNRVKD-STRS
RHMANQE-----A--NTMSRSQTNQELYIAS-SSGSE-----------------------
-DESVTTSWFWARNKTNTWS--GPREDP-NRRSRFRSKKEVYV------------EPSSG
SEREDHMESWFWAGEEAKFRSKTRTGKEANTRARHRAKRETCIDFMPGSI------DVIK
KESWFWPEENA---------NTF-----SRPMIKKEARSRAMAK----------------
KE----AKTKARARAKQEVRS-----EEEALIGTWFWATDESSVADEASTVSSPQVEDES
IVGSWFWTEEGASMGTGASSES-KPSTEGEPIGDSLFGAG-EKTSMKTGAEVTSESLLAA
DDE-QVIIGSWFWASEE-VN---------------------------------QEAEEET
IFGSWFWVIDEAS-VESGIGVSCE-------------------------------SRPR-
-SEEEEVIGSWLWSGEQADIEAGIREE----------ARPGAEEETIFGSWFWAENQTYR
DCR------AEASCDNMQGAE----EEEPIIGSWFWTRVEACVEDDVNSKSNLEDKEE-A
IISSCFGAKEEVSMKHGTGVRCRFMAGAEETSNRSCFWAEKEPCMYPANGGSWKSRPEEE
-----EDTVNSWFWSRKHTEPEAITA------------------------SWLWAAEESN
I-DGTGEEAKLLTEEETMINSWFWKDD-EAMSEATHREESRPEAEENDIIGSWFWAGEED
RLEPATETR-EDRLAAEKE-GIVGSWFGAREEI-RREAGSCSKSSTKAEEEEVIIGSWFW
EEKASLEAVAGAGFESKPGTEEE----EITVGSWFWPEE-ASIEPGSQAVEEMESETEEE
TIFGSWFWAGKV-----VSVEAGIGCVSKAEDD-EEMI----------------------
-VESWFWSGDKAIKETGTMATCESKPENEEGVIAGSWFEAEDEVDNRTDNGTNCEPWTLD
DEDEAIVGSWFWAGDETHFES-NPSPVFRAVCTSTCSVEQEPDPSRRPQSWEEVTVKFKP
-GPW----GRVGFPSISPFRFTEDA-----SEMFGGKPRNMVLSPEG----E--DQESLL
QPDQ--PDPEFPFQYDPSY--------------------RSVREIREHLRARESAEPENW
SCSCIQ-----CELKIGSEEFEELLLLMDRIRDPFIHEISKIAMGMRSASQFTR------
----------DFIRDSGVVSLIEALLNYPSSRV------RT-RFLENMIRM-APTYPNLN
MIQTYVCKVCEETLTCSLDSPEQLSGIRMIRHLTTTTDYHTLVANYMSGF-LSLLATGNT
K-TR-FHVLKMLLNLSENLVMTKELLSDE---AVSEFMGLFHRDETN----------DNI
QIVLAIFENIGNNIKKET-VFC---------DDDFDL--EPLI-SAFHKVEKFAKELQGK
TDNQNDPEGDQEN-----------------------------------------------
-------------------------------------------

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------------------------------------------------------------
---------------------------------------MTGTKN--KTRAQAKTEKK-P
ITQAKAGAEREATGV------VRPV---------------------AKTRAKAKAKTGSK
-----TDAV---------------------------------------------------
------AEMKAV-------------SKNKVVAEVKEGSLSEPKTLGRAM-----------
-----GDF----------------------------SPKAGNESTSSTCKNEAGIDAWFW
AGEE------------------------ATINSWFWNGEEAGN-SSST------------
---------KNDKP--------EIGAQVCA----E-------------------------
------------ELEPAAGADCKPRSGAEE------------------------------
EEEENVIGNWFWEGDDTSFDP-NPKPVSRIVKPQP---VYEINEKNRPKDWSEVTIWPNA
PAVTP---AVLGFRSQAPSEASPPS----YIVLASAEENACSLPGA------TACRPSRN
TRSCSQPIPECRFDSDPCI--------------------QTIDEIRRQIRIREVNGIKPF
ACPCKM------ECYMDSEEFEKLVSLLKSTTDPLIHKIARIAMGVHNVHPFAQ------
----------EFINEVGVVTLIESLLSFPSPEM-------RKKTVITL-NP-PSGDERQR
KIELHVKHMCKETVSFPLNSPGQQSGLKILGQLTTDFVHHYIVANYFSEL-FHLLSSGNC
K-TR-NLVLKLLLNMSENPTAARDMINMK---ALAALKLIFNQKEAK----------ANL
VSGVAIFINIKEHIRKGSIVVVD----------HLSY--STLM-AIFREVKGIIETM---
------------------------------------------------------------
-------------------------------------------

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---------------------------------------MTGSKN--KARAQAKLEKR-A
NAQARAVAEREAANA------CRAA---------------------GKNRDKGKTKAGTR
-----TDAV---------------------------------------------------
------AEMKSG-------------SKNKAGAEMREGARSDSKAPGRGT-----------
-----WDY----------------------------YHKAENKVTRPTRKD-KASDAWFW
TGEE------------------------SGINSWFWKGEEVSN-NSVA------------
---------KCENK-------TNTGTQGRT----E-------------------------
------------ESEPTPRASHKSRSGAEE------------------------------
EEEENVIGNWFWEGDDAGFDP-DPTPVFRIVKPQP---VDEINEKNRPKDWSEVTIWPKA
PAVTP---AVLGYRSQDSSEGRPSS----YIVLASNEEETPA------------TASTKN
TRSSLQSIPEYPFGSEPCI--------------------QTLDEIRQQIKIREMNGIKPF
ACPCKM------ECYLDSPEFEKLVNILKSTTDPLIHKIAQIAMGIHKVHPFAQ------
----------EFINEVGVVTLIESLLSFSSPEG-------IKKTVITL-N--SSGDERQH
KVEFHVKHMCKETVSFPLNSPGQQSGLKILGQLTTESVHHYIVVSYFSEL-FHLLSQGNR
K-TR-NLVLKVFLNMSENPRAARDMINMK---ALAALKLIFNQKEAK----------ANL
VSAVAIFINIKEHIRKGSIVVVD----------HLSY--STLT-AIFREVKGIIERM---
------------------------------------------------------------
-------------------------------------------

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---------------------------------MGYARKVGWVTAG----------LVIG
AGACYCIYRLA--RGRRQSKEK-MA----EGGSADVD--DAG----------------DC
---------------------------------------------------------SGA
--RYNDWSDDD-------------------------------------------------
DDS----------------N--------D-------------------------------
------------------------------------------------------------
-SKSIVWYPPWAR-----------------------------------------------
------------------------------------IG----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------T--------------------------------
-----------EAGTRARARA---------------------------------------
------------------------------------------------------------
-------------RARAT---------------------------RA----RRAVQKRAS
PNSDD--------TVLSPQELQKVLCLVEMSEKPYILEAALIALGNNAAYAFNR------
----------DIIRDLGGLPIVAKILNTRDPIV------KE-KALIVLNNL-SVNAENQR
RLKIYMNQVCDDTITSRLNSSVQLAGLRLLTNMTVTNEYQHILANSISDF-FRLFLAGNE
E-TK-LQVLKLLLNLAENPAMTRELLRAQ---VPSALGSLFNKKENK----------EVI
LKLMIVLENINDNFKWEENEPA---------QNHFSG--GSLFF-FLKEFQVCADKVLGI
E-SHHDFLVKVKVGKFAAKLTERMFPKSQE------------------------------
-------------------------------------------

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------------------------------------------------------------
-----------------------MVDSGTEARARGKAEAGLQDG--------ISGP----
------ATARVNGKTQAKAVA-----EAELKTESV----TQAKAGDGAMTRMHKVTYREA
--MAVTREVSKM------------------------------------------------
------------------------------------------------------------
-----------EDTTKSRVMVETKTKPLA-ERSIVPQTKSKAMPMSGV--SAVTKSEVKV
V-----------------------------------------------------------
-------AVIEANIRSYAKSH-----DKANTGSRPDR-----------------------
--------REEA------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------SIGM-----------------------------KSSDEDEENICSWFW
TGEE------------------------SSVGSWFWPEEETSLQV---------------
-----YKPLPK---------------------I-QEKP----------------------
------------------------------------------------------------
----------------------KPAHK------------------------PTLTIKQKA
-IAW----SRA--RYIVLVPIE------------GG--EQS-LPP---------EGNWTL
VETLIET--------PLGIRPLTKIPPYHGPYYQTLTE------IKKEIRQREKYGPNPK
ACHCKS-----RGFSLEPKEFDKLVALLKLTKDPFIHEIATMIMGISPAYPFTQ------
----------DIIHDVGITVMIENLVNNANVKE------HP-RALSIVDDS-SESSEEPK
SGESYIHQVCKDIVSCPLNSPVQLAGLKLLGHLSVKFDDHYVITSYIPDF-LTLLNKGSV
K-TK-FYVLKVFSCLSKNCANTRELISAK---VLSSLVAPFNKHESK----------ANI
LNIIEIFENINFQFKTKVKLFTK--------EK-FTK--SELI-SIFQEAKQFGRKLQDL
A-EHSDPEVRDKVIRLILKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------MSRARE--VGWMA
AGLM----IGAGACYCVYKLTV------------GR--EDSDKLEE------EEEEEWDG
DEELGEEESEMHFDFTTMARPWTDDGDWTKPGAPGGNEDRHSGGGKANRT--HPTKQRPF
PYGHK--------NTWSAQGFNNVSCVLDLSKSPFIQVKVLFAQPKDAGFSRSH------
----------GINNHLASLSIVGNMIPTPNPTV------EE-KAFCALGNF-NVSAENQA
QNKMYINQVCRETVSRCCNSFLQQAGLNVLISMTAINN---MLAKSVSDLKLPLISEGSG
C-TK-AQVLKPLMGLSEKPALAGGLLGAH---ELLSFMPLSIRNGNR----------EIL
LDTLAP------------------------------------------------------
------------------------------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MPEN--KSGTHAKTRKG-A
GIKA--EAEREATGI------VKA-------------------------------KAGFE
-----TDAV---------------------------------------------------
------AERKGV-------------SEAKVVTEMKARALSEPTALVKGV-----------
-----AKA----------------------------MPRSWARS---GHKDETDTDAWFW
AGEE------------------------ASIGSWFWNGEEA-GDQTKA------------
---------KDEGE-------TDIGASINT----EEL-----------------------
------------GIEAATGASWKPRP-V--------------------------------
-----VIWKWFWDGDKISFDP-NPRPLYRTVKPRV---TCEIEERNRPKDWSEVTIWPNG
PAEIP---ASLASGYQVPSRTRPVS----CTAQSSAEKNTGSLPAA-------EASLHEG
TSICLQSIDAYPFDSETCT--------------------QAIEKIRGQIRIRELNGIRPF
PCPCKM------ECRLNSEDFEKLVSLLKSNADPVIHKIAQIAMGIIKVHPLAQ------
----------QLINEMGVLTVIESLLHFQFPNM-------TRKTEITL-NP-ISVEQRQR
RSILHVVHMCKETVSFPLNSPGQRSGLKELGQLSADRNHHLIVAAYLPEL-SRMLSLGNH
K-TR-NLVLKVLLNMSENPIAARDMMNIE---VLSALKLIFHQKEAK----------ANL
VTAVAIFVNIKKHIRRGLIVVVN----------PVSY--NELK-AVFREVKTIIEKS---
------------------------------------------------------------
-------------------------------------------

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------------------------------------------------------------
---------------------------------MGYARKVGWVTAG----------LVIG
AGACYCIYRLT--RGRKQNKEK-MA----EGGSGDVD--DVG----------------DC
---------------------------------------------------------PGA
--RYNDWSDDD-------------------------------------------------
DDS----------------S--------E-------------------------------
------------------------------------------------------------
-NKGIVWYPPWAR-----------------------------------------------
------------------------------------IG----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------T--------------------------------
-----------EAGTRARARA---------------------------------------
------------------------------------------------------------
-------------RARAT---------------------------RA----RRAVQKRAS
PNSDD--------TILSPQELQKVLCLVEMSEKPYILEAALIALGNNAAYAFNR------
----------DIIRDLGGLPIVAKILNTRDPIV------KE-KALIVLNNL-SVNAENQR
RLKIYMNQVCDDTITSRLNSSVQLAGLRLLTNMTVTNEYQHMLANSISDF-FRLFSAGNE
E-TK-FQVLKLLLNLAENPAMARELLRAQ---VPSSLGSLFNKKENK----------EVI
LKLLVIFENINDNFKWEENEPT---------QNAFSE--GSLFF-FLKEFQVCADKILGI
E-SHHDFLVKVKVGKFMAKLAEHMFPKTQE------------------------------
-------------------------------------------

------------------------------------------------------------
--------------------------------------------MGRTQEVGWVTAGLVI
WAGTCYYIYKFTKGRAQSVRTLARNGSTV-KMETVVG----VQSQTLAISEAE----IKT
KPQAETGAETGTRGGPGAEVETKATAIARHRANSQ----AKTMVEAEAETQSE-------
SKVVAGTLVMTEAVTLTEVK--AQAREVAMKEAVTQTDAEAGKIVKKEAVTQTK-AKAWA
LVAKTEAKREAMTQTKAETHILAEKETEINRVMVTQSETLAVPRE----VVKMGATNKTG
IVDETKTRALEETVSVAKTQSEARPGATVDARGNPNGMSREVAGVDMKSCAQSQAVTKIK
GDDMPGAGIEDMGNCK---------------------------TMSRAESGADTRASAQP
QIVAKTQTEAIPAAKVDAGSNTNAMCKVGAEADVRACV-QPQTVVKKQAEVTSCAR-VDG
RGNTNVISKAITGADMRAAAQPQAVASAHTEAMSDAKVKDRGNPNAMTKAGARANLRANS
QVEALPDARDKSRGNPNVIAKVGDGTDMLSCT-QPQLVASVQANALSDGRIKVKGNVNSM
PKEGAGVDMKAQ--GMAQSQGEALPNTRGKARGKAKAKCKTGSGTDMKTCTQPQTGVKTP
AEALLDSRVDGRGNPNATSKAGTKADQRACGQPLVVANPQGEALPGAKNKVKGNPHAVLK
VGAGEGTADSAQPQAV---------------------------------------VSFQG
EALLGTKSKVKGNPNVVIKAEVGAGAIGTAQLQIEASSKGEALLDSKNKVKGNSNAVSKA
GAGTDTTGSVQPQIVANSQGEVLPSAKNKVRGNSTTVPNSGVGPYT--------------
--------------------------TDSAQPQAVASSQGEVLPGAKNKVKANLNALSKA
EAGMGAT-----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------GSVQSQAVTNAHCETLPGAKNK
VKGNWNAVSKAGAGMDTRGSAQTQAVANSQGEVLPGARNKVKGNPNVVSKAGAREDTMGS
AQPQVVANSQRETLPGARNKVKGNSNVVSK-----AGAREDTMGSAQPQVVANSQRETLP
GARNKAKGNSNAISKAEAGAGIMGSVQVQVVASSQGEFLPGAKNKVRGN--FNAVPKAEA
GADTVGSAQPQAVANSQSETLLGARNKVKGSTNTVPKAGTGAGTRHSAQPQIVAGSQ---
-------------------------------------GETLPGARDKAMPSSEAETTAED
EVYAKPE--AEAMPISESEGGSGTQASRKTQPNIHDYYWNGIGVEDWIAAERWIKFRFQT
MDGDWENSVSWADDENEASIGSWSGV-SDK--AGIIRSWAVAC----DEASVKSWAGARA
ENEVGIGTWARAG-EQASGGLWAGGQTSEGTWAGD------------KASGGAWTGAENQ
ASGGSWVLAGSQAIGELWAAGQASNGSWPGGQASGVSWVGEEAIGGSWTG--------AE
NQASGGSWAGA------------------------GAGNMSSVSYWAGVVDQASG-GSWA
GT------------SDQSGGGSKPRFEDQTSGEGSWAGAGDQASGGSRLGPEDQSSGRSW
ADTADQASGGSRLGHVDQSSGG--------------------------------------
----------SWAGTLDQSGGGSKPRFENQTTEEG-SWAGAGGQAGGGSKVGSEDQSSGR
SWANSGDQISGGFLVGVVDQANGGSWTGA----GHPASGGPKPIFEDQASGRGSWA-DAG
DQVVGDSRLGLRDQSSGDSWAGTGDQASG------------WF-------------CVCP
G---SQ-TNGGSWGGANGQDVGGSRPGPTNQSSAGSWDSPGSQVSGSSWTGAGAVDQVGG
CSKPGFEDQAIGGGFWPGAGDQTGGGSRPGSEDQS--SGIGSWGVAGGQVL---------
------------------------------------GGARP--ADQSSGGPWAGTG---N
QVSGRSWIGPG--NQ-AGDCSKPEFEDQ-ACGGGSWAGAGSQASGESWAGSTPGNE----
---AIGG-----S--RM-----------------GSE-----------------------
--------------------------DQATGGSWARSEDQASGRFQVSVEVEANEGFWFG
PGAEAVIGSWCWTEAKADIVSKPDDNDEATTISRSEAGEEAIICSRTEAE------NKAG
SGSWISSEEVA--------YMGSCVGAEAG--A--------------E--AGAEAE--AG
AE----------------AVA-----E---------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---AEAEAGAEAGAGA-----------------------------GAEAGAEAGAGVWSW
DGDA------------------------TTVESRLGAGGDAGV-----------------
---ESWTLAKD------V-GEDELSRESSP-DI-EEIS----------------------
-LRSLFWAESENSNMFRSK--------SGKD--ANFDSGVGDNT-STKDKFEA-------
-AGGVDIGSWFCDGNENTNED-KSASKAKAKKSSE-S----------RGTYPSM-VPGAG
MGSW----DGAMIWSETK--FP------------HQ--SEASFLVED----E-----SR-
KQ-T-----------------------------------RT------------GEKPRPW
SCRCKR------EANMDPRDLEKLICMIEMTEDPSVHEIANNALYNSADYPYSH------
----------EAVRNVGGISVIESLLNNPYPSV------RQ-KALNALNNI-SVAAENHR
KVKTYLNQVCEDTVTYPLNSNVQLAGLRLIRHLTITSEYQHMVTNYISEF-LRLLTVGSG
E-TK-DHVLGMLVNFSKNPSMTKDLLIAN---APTSLINIFSKKETK----------ENI
LNALSLFENINYHFKRRAKAFTQ--------DK-FSK--NSLY-FLFQRPKACAKKLRAL
AAECNDPEVKERVELLISKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MGRTREAGCVAAG----------VVIG
AGACYCVYRLT--WGRDE-NEKIWD----DNEEDDEE--ESSDIV---------------
----------------------------ETGVQTG------KGAKANAGVGAGARLQDE-
----------------------------SKV------------KAEVGMELQNGSDVKAE
AHL----------------G--------AQSGGGLE---AKA------------------
-----------------KALFST-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------L----------------------------------
----------------KEQASAKASRGARLGTIS--------------------------
---------------------------------------------GNRTLAPSLPCPGGR
GG---------GCHPTRSGARS---------------------------------GSRAS
GKTKGRTRGKSTRTPA-T---------------------------SW----PVRRGKFNF
PYKID--------DILGASDLQKVLNILERSNDPFIQEIALVTLGNNAAYSFNQ------
----------NAIRELGGLPIIAKLIKTKDPII------RE-KAYNALNNL-SVNAENQG
KIKTYISQVCDDTMICRLDSAVQMAGLRLLTNMTVTNHYQHLLSYSFPDF-FALLFLGNY
F-TK-IQIMKLIINFTENPAMTRELVSCK---VPSELISLFNKEWDR----------EIL
LNILTLFENINDNIKNEGLASS---------KKEFSR--SSLFF-LFKESGVCVKKIKAL
A-NHNDLVVKVKVLKVLTKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MGGPRGAGWVAAG----------LLLG
AGACYCIYKLT--RGRRR-GDR---------ELGMRP--SK-------------------
------------------------------------------SA----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------E--------------------------------------------DLT
DGSYD--------DVLNAAQLQKLLYLLESTEDPVIIERALITLGNNAAFSINQ------
----------AIIRELGGIPIVGNKINHSNQSI------KE-KALNALNNL-SVNVENQI
KIKIYINQVCEDVFSGPLNSAVQLAGLRLLTNMTVTNDHQHMLHSYITDL-FQVLLTGNG
N-TK-VQVLKLLLNLSENPAMTEGLLHAQ---VDSSFLSLYDSHVAK----------EIL
LRVLTLFQNINNCLKIEGHLAV---------QPTFTE--GSLFFLLHGE--ECAQKIKAL
V-DHHDAEVKEKVLTIIPKI----------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------MAGSGTEARAREKAEAGLKDG--------ISGP----
------AAARVSGETQAKAVA-----EAKLKTESV----TQAKAGDGAMARTHTVTYTVT
--MAVTREESRM------------------------------------------------
------------------------------------------------------------
-----------EDTTKTRVVVETKAKPLA-EHSIVPQTKSKAMPMSRV--SAVTKSEVKV
V-----------------------------------------------------------
-------AVSEANIRSYTKSH-----DKANTGSRPDR-----------------------
--------REEA------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------SIGM-----------------------------KSSDEDEENICSWFW
TGEE------------------------PSVGSWFWPEEETSPQV---------------
-----YKPLPK---------------------I-QEKP----------------------
------------------------------------------------------------
----------------------KPTPK------------------------PMLTIKQKA
-IAW----SRA--RYIVLVPIE------------GG--EQS-LPP---------EGNWTL
VETLIET--------PLGIRPLTKIPPYHGPYFQTLAE------IKKQIKQREKYGPNPK
SCRCKS-----HAFSLEPKEFDKLVALLKLTKDPFIHQIATMIMGISPAYPFTQ------
----------DIIHDVGITVMIENLVNNPNVKE------HP-RALSMVDDS-SEPSEEPK
AEESYIHQVCKDIVSCPLNSPVQLAGLKLLGHLSVKFEDHYVITSYIPDF-LTLLNKGSV
K-TK-FYVLKVFLCLSKNQANTRELVSAK---VLSSLVAPFNKNESK----------ANI
LNIIEIFENINFQFKTKAKLFTK--------EK-FTK--SELI-SIFQEAKQFGQKLQDL
A-EHSDPEVRDKVIRLILKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
---------------------------------MGGARDVGWVAAG----------LVLG
AGACYCIYRLT--RGPRR-GWR-----------RLRP--SR-------------------
------------------------------------------SAE---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------DLT
DCSYD--------EILNAEQLEKLLYLLESTNDPIIVEKALVTLGNNAAFSANQVSLLFL
HTVVVM------I---------------LD-----------------ISKK-SGLLSLSF
CLQVYVQRVCEDVFADPLNSAVQLAGLRLLTNMTVTNDYQHLLSSYIAGL-LHLLLIGNG
S-TK-VQVLKLLLNLSENPAMTEGLLSAQ---VDSSFLSLYDGQIAN----------EIL
LRALTLFQNINNCLRVEGCLAS---------QPPFAK--GSLFSLLYGE--DCAQKMRAL
V-YHHDVDVKEKVLAIMPKF----------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
---------------------------------MGGPRGIGWVATG----------LVLG
-GACYCIYRLT--QGQRQ-GGR---------RLGLCP--WR-------------------
------------------------------------------S-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------A-------------------------------------E---DLT
DGSCD--------VYLNIEQLQKFLYLLET-TDPVITERALVTLGNSAAFSANQ------
----------AIICELGIIPIMGSKINSLNHSI------KE-KTLC-LYNL-SVNIE--K
KIKTYINQVCADVFSGPLNSAVQLAGLRLLTHMAVTNDHQHMLNSYIADL-FHVLLTGNV
N-TK----------------------------VDSSFLSLYDAHTGK----------EIL
LRALTLFQNINTCLI-EGRIAI---------QPTFTK--GSLFF-LFGE--ECPQK----
------------------------------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
--------------------MAGTETETR-P-----KATTGAETE---AGGS--AGAEVE
ITTPAKAR--------------------P-------------------KANSQAMTMAEA
EAEIQSEPQIIAKTQAEAMLGAKASTKSQVETLPGTRPKTK------------GK-----
---GKSKSGAK--AE-LRACGQPQTMAS-SQGEAL-PGAKNKPETDTTSSAQPQTE----
---ASSQ-----G--EALPGTKNKGNPNAVS-KVGTGPDTAGSAQPQVVPNFQGEVLPGT
KNKVRVKPCLVPG----------VRSDVIP-WLWS--IPRARDGY------WENSMSWAD
DENEASIESWSGASDKS----IRSWAGVKAEN----------------------------
---------------------ESWARAREQANKGSRPGFVNQSS--VGSWASTGNQ----
-----------------------------------------------------------A
SGGFLVGTVDQAGGGTKP----------------------------------RF------
EEQ---------------------------------------------------------
------------------------------------------------------------
---AS-GRASWADNGGQAG--------------GGSRLGPRDQSA--GDSWVG-------
-------------------TG-----DQARSVL-RWRP---------VKDPGLELGLR-L
VQGPASGAKEEAKISSR----------FGAED----------------------------
------------------------------------------------------------
----------------------------------------------KASIGSWISS----
--EEAACMDSCVGAGA-----------------------------EAGAGTEVGKESWLW
DGDA------------------------ATTGSRLGAEEEACM-----------------
---GPWTLAED------V-EEDELSRASSP-DI-EEIS----------------------
-LRSLFWADSEKSNEFRSK--------RERS--VNFERGAGDKA-SAEDKLEAP------
TGGGADERPWFWDGNENRSED-KPALKTKAKKSAE-S----------RGTYPSM-VPGAG
MGSW----AGAMIWTEMK--LP------------YQ--NESCFPPED----E-----LR-
KQ-I-----------------------------------RY------------EEKTQPW
TCRCKR------KANMDPRELEKLICMIEMTEDPSIHEIANNALYNSPEYPFSH------
----------EVIRNAGRISIIESLLNNPYPSV------RQ-KALNALNNI-SVAAENHR
KVKTYLNQVCEDTVTYPLNSNVQLAGLRLIKHLTIISEYQHMVTNYISEF-LRLLTVGSG
E-TK-DHILGMLLNFSKNPSMTKDLLIAN---APTSLINIFSKKETK----------ENI
LNALSLFENINYHFKRRAKVFTQ--------DK-FSK--NSLY-FIFHRPKACAKKLRVL
AAEYSDPEVKKRV-----------------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
---------------------------------------MMGGKN--KGRAQAKTEKK-A
NVQAKAGAEKEAASV------VKPA---------------------AKTTAKAKAKEGPK
-----TDAA---------------------------------------------------
------ADTKAV-------------SKSRAVAEVKEGTRSEPKAPLKIS-----------
-----SDL----------------------------NPKAENKATSSAYKDKTGTDTWFW
AGEE------------------------ASINSWFWKGEEAAS-PSVA------------
---------KCESK-------TDTGAQGHT----E-------------------------
------------QLEPTSGPSYKSRSGAEE------------------------------
EEEENVIGNWFWEGDDNSFDP-NPQPVFKIVKPQP---VDEINEKNRPKDWSEVTIWPKA
PAVVP---AVLGYRSQASCETKPSS----YVVLASDEEDTQSSA----------DKHSHS
KRSSSQPIPEYPFGSDSCI--------------------QTLDEIRHQIKIREANGIKPF
ACPCKM------ECYLDSQEFEKLVSILKSTTDPLIHKIAQIAMGVHKVHPFAR------
----------EFINEVGVVTLIESLLSFSSPES-------RKKTVITL-NP-PSGDERQH
RVEFHVKHMCKETVSFPLNSPGQQSGLKILGQLTTESVHHYIVVSYFSEL-FQLLSQGNR
K-TR-NLVLKVFLNMSENPNAARDMINMK---ALAALKLIFHQNEAK----------ANL
VSAVAIFINIKEHIRKGSIVVVD----------HVSY--STLT-AIFREVKGIIEAM---
------------------------------------------------------------
-------------------------------------------

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--------------DIDLGHV--ENQGQD-TGLYNWV-TMTRSKG--KNRAQVKTEKR-A
GVQAKTGAEREATAV------VRPT---------------------PKTQAKGKAKAGSK
-----TDAV---------------------------------------------------
------AEMKTM-------------SKNRAVAETKEGALSGSKAVVKAR-----------
-----KDI----------------------------GRKSQNEATSSTRKNEASTEACLC
AGEE------------------------T-ANPCFWNGGEAGN-RFSA------------
---------KGEGKP--------DTAQVRA----EEL-----------------------
------------XXXXXXXXXXXXXXXXXX------------------------------
-XXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXX---XXXXXX-XXXXXX-XXXXXXXX
XXXXX---XXXXXXXXXXXXXXXXX----XXXXXVSIENTPSFL--------VTECSSGS
TLSCSQNISEYPFGSDTCV--------------------QTIQEIRRQIRIREMNGIKPF
ACPCKM------ECCMGSEEFEKLVSLLESTSDPLIHKIAQIAMGIHNVHPFAQ------
----------EFINEVGVVTLIESLLSFPSTEM-------RKKTVITL-NP-PSENERQR
KVELHVKHMCKETISFPLNSPGQQSGLKILGQLTTESVHHYIVASYFSEL-FNLLSQGNC
K-TR-NLVLKVLLNMSENPTAARDMIDMK---ALAALKLIFNQKEAK----------ANL
VSAVAIFINIKEHIRKGSIVVVD----------HVSY--NTLM-GIFREVKGIIEAM---
------------------------------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
----------------------------------GGARDVSWVAAG----------LVLG
AGVCYCAYRLT--RGPPR-GPR---------RLQRRP--SK-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------SA-------------------------------------E---DLT
TDSYD--------NILNAEQLQKLLYLLEFTEDPEIIERALVTVGNNAAFSTNQ------
----------VIIRELRGIPIIGSKINHLNHSI------KE-KALNALNNL-SLNVENQA
EIKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXX
X-XX-VQVLKVLVNLSENPAMTEELLGAQ---VDSAFLSLYDSQVAK----------EIL
LRVLTLFHNINNCLKKKDRQAL---------QCKFTK--GSLFHLLYGE--ECAQ-MRAL
L-SHHHVDEEEKVIV-IPKI----------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
---------------------------------------------------------DLT
SGSYD--------DVLNANQLQKLLYLLDSTDDPFITERVLVTLGNSAAFSVNQ------
----------AIIRELGGIPIVGNKINSPNQSI------KE-KALNALNNL-SVNVENQI
KIKTYVHQVCEDVLAGPLNSAVQLAGLRLLTNMTVTNDHQHLLSSYITDL-FHVLLAGNG
N-TK-VQVLKLIVNLSENPAMTEGLLGAQ---VDSAFLALFDSHVAA----------EIL
LRALTLFQNINNCVKAEGRQAL---------KPTFPQ--GSLFSLLYGE--ECAQKMRAL
G-AHHDADVKEKAAAITPAF----------------------------------------
-------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------MTGTEIAPHSDTKSEKKPGEELG-------VV-----------GAERENEAPM
VVRPKV--------------------------RPQPQAASGARPKTESKSRAKSR--NDS
------K------------AANGSRSKN----------------------------ESQR
GTGARPKS----------------------------ESKEMSGARNKNE------AWAVG
GARKT---DAKA-MDTRSKDEA--------------Q--------------AWAQTE---
-------VLSRTEGITPINVLAWSVVSPES--GPYAKPMTTSAESNLVGVDAEPYSGSQ-
-VPPDLQPWLASG-NNTS------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---SGSWCYPRPRAR-EEASKESEFWSADETATIPSLWDGEEASMRSWSREET---NTRS
RHRAKHQ-----D--NPRSRPKSKKGHCTDS-WSGSE-----------------------
-EESGNPFCLWAGENTNNFF----------------------------------------
---------------------R----DEANMRSKLRAKREEF--FESESD------DEYN
KETWFLPEE-A---------TGR-----YKPRNKEGPNTVLKSK----------------
TQ----KDV-NSDRVNQETKL-----EEEVIIGSWFWDEQEA------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------SI
KDG------ASATCEPDSGTE-----EGAI------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------GGSVFWTEEKS
SLGA--------------------------------------------------------
-----------------------------------------------MAREETRPES---
------------------------------------------------------------
------------------------------------------------------------
-EEEAIFGTWFWDRDEACFDL-NPNPVYKAGPRFRDLAEEELNVSSRPKTWDEVTVEFKP
-VTC----HRIGFPSPSPFRIPEEMETQLYTEMFEAKPKNVEVTPEE----E--ERESPP
PAEQ--PVNEYPFQYQPTY--------------------RSVREIREHLKAKESAE-ENW
SCKCIQ-----CELKIGSAEFEELLILSDRIRDPFIHEISKIAMGMRSASQFTR------
----------DFIRDSGVVSLIETLLNFPSTRE------RT-SFLENMIQM-APTYPNLN
MIETFVCQVCEETLSHSMGSPEQLLGLRLLRHLTTTTDYHDLISKYMGGF-LSLLTTGDA
K-TK-FNLLKVLLNLSENAMVANTLFSPD---ALSVYVAHLNVEESN----------DNI
QI----------------------------------------------------------
------------------------------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
---------------------------------MGRTREAGCVAVG----------MVIG
AGACYCVYRLT--WRKDE-NEKTWD----DDDEESSD--TSE------------------
-----------------------------TGVETE------KGAKINVGVGVGAKPQSDT
-----------------------------KA------------KAEVRLGLESGPGVKKE
SHC----------------G--------SQSGGGLE---AKA------------------
-----------------KALFNI-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------L----------------------------------
----------------KEQASAKVGKGGRVGNIS--------------------------
---------------------------------------------GNRTLAPSLPCPGGR
GG---------GCHSAKSGARA---------------------------------GSKAS
GKSKGKARSKSTRALP-T---------------------------TW----PVRRGKFNF
PYKID--------DILSTPDLQKVLNILERTNDPFIQEVALVTLGNNAAYSFNQ------
----------NAIRELGGVPVIAKLIKTKDLII------RE-KTYNALNNL-SVNAENQG
KIKTYISQVCDDTMICRLDSAVQMAGLRLLTNMTVTNHYQHLLSYSFPDF-FALLFLGNH
F-TK-IQIMKLIINFTENPAMTRELVSCK---VPSELISLFNKEWDR----------EIL
LNILTLFENINDNIKSEGLASS---------RKEFSR--SSLFF-LFKESGVCVKKIRAL
A-NHSDLVVKVKVLKVLTKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------MTRTEFELYTEDKHEKKPEEKVV--------S-----------AAGIENEVPL
VVRPKV--------------------------RTQAQIMTGARPKTKTKVVPGTWPKT--
------------------------------------------------------------
------------------------------------------------E------ARAMG
SVYTKY--KIKKIHESRSKDDA--------------Q--------------TWALSEFG-
-----PESISKMEQESQINVIISPGVSSDS--GSVANTKCLFMDRESINIDNESFPGKKV
HSQVGFPSSFVSG-KVTD------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---SEPWSYPRHISK-QKPSQNSDFNWVDKS-VNSWFWSQEEVNGRFHPRNRIKA-STRS
KYMSKQE-----A--TNYSRHKNKQDLYIVSSSSGSE-----------------------
-DESLKTSWFCGKQKTNPLS--KSREEV-NSRSWFRSEKEVNI------------EFSPR
SEYENAMKSWFWDREETKYSTLPRTRKETNERARYSPKQEACIETMTEST------DVNQ
KESWFWPEEKG---------NTF-----LRCNTKKESRAQAMEK----------------
EE----A----RTRDKREERP-----QEETFIETWFWATEESSLMDVPSIKSSPQLKDES
IIGSWFWTEEEVSMETRSSSKS-RLEVK-ELIDNSCLGDG-EKTSIEMGAEATSQSILAA
NDE-EVIVGSWFWAGEE-VN---------------------------------PEPKEET
IFGAWFWSTDEAS-GESDVGISCE-------------------------------SRPR-
-S-AEEVIGPWLWAGE-VSIGAGVGEE----------FSQESEEETMYLSWFWSENQTSM
DSA------TEASSDVPGAEE----EEDPMFGSWFWARVDACEESTVNSKSSLEDEE--A
IISSSFVAREEANMKYGAGARCKFMAETEDT-NKSCFWAEEEPCMYHASRRNWKFRAEEE
-----EDIADSRFWSRKYTRPEALVG------------------------SWLWAAEEGS
TDYKIRQEAMLPTKEKTMTKSQFWKEDKDTTIEVTDRKESWPEAEEEDIIGSWFWSEEED
RLEAQREGREENSLGVEEEESVFRSC--GKQEAV-TESGFSSKYSSKADAEEVIVGSWFW
EQETSLEAVTADTFESKTGTEEE----EIIVGSWFWPKE-ANIEAGSQAVEETRSKTEEK
TILESC-CAKKE-----VNIEAGMCCVSKPEYD-EEMI----------------------
-VEAWFWSTDKTIKETGTVATCECRSQDDEEEVVETWCRATDEVNNGTDDGTNCESRILV
-DEEDIVGSWFWIGDEAHFES-NPSPVFRATCESWGSVKEEPDLSHRPQSWEEVTIQFKP
-GPW----GRVGFPSLSSFIFPREA-APLFSELFGE-NRHVERIAED----E--EQESFL
H-----VEPEFSFQYDPSY--------------------RSVQEVREHLRAKESAESESW
SCNCIQ-----CELRIDSEEFEELLLLMDRIQDPFIHEISKIAMGMRRASQFTR------
----------DFIRESGVVSLIETLLNYPSSRD------KT-RFLKEMILT-APSYPNLN
MIQTYVCQVCEETLAYSVDSPEQLSGLRMIRYLTTTTDYHTLVANYMSGF-LTLLATGNN
K-TR-FHVLEMLLNLSENFIMMKELLSTE---AVSEFMGLFYREETN----------DNI
QIVLAIFENIGTNIRKDTVFID--DD-----DDDFSL--EPLI-SIYHEVEKFAKQLQSK
IDNQNDPEADQEN-----------------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------SVDHGTPLRGRGGAEVCLKAG--------ISGP----
------ANPRAKAKIQ-------------------------AKSGDGAVARTQTVTYTEA
--VA-------M------------------------------------------------
------------------------------------------------------------
-----------EAMAKTRVMTETKAKSLA-EPGIVPQIKSKLMPMARV--SAVTKYEVKA
G-----------------------------------------------------------
-------AGSETNIRSFAKAH-----DKVNIESRSQR-----------------------
--------RREDSIKFR----------SS-------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------D-----------------------------------------EDEENVCSWFW
TGEE------------------------PSVGSWFWPEEETPSQV---------------
-----YKPLPK---------------------I-QEKP----------------------
------------------------------------------------------------
----------------------KPI--PK----------------------HELTIKQKA
-AAW----SRA--RYSVLVPIE------------GG--KPS-LPP---------EGNWTL
VETLIET--------PLGIRPLTKIPPYNGPYFQTLAE------IKSQVRYREKYGPNPR
ACRCKS-----RDFSLEPKEFDKLVALLKLTKDPFIHEIATMIMGISPAYPFTQ------
----------DIIHDVGITVMIENLVNNPNVIE------HP-RALNIVDDN-SESSEEPK
PGESYVYQVCKDIFSYPLNSPVQLAGLKLLVHLSVKFEDHHIIINYIPDF-LTLLSKGSV
K-TK-FYVLKVFLRLSKNQANTRELISAK---VLSSLVAPFNKNESK----------ANI
LNIIEIFENINFQFKKKVKLFTK--------EE-FTK--SELI-SIFQEAKEFGQKLQDL
V-EHSDPEVRDKVIRLILKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------MVDSGTEARARGKAEAGLQDG--------ISGP----
------ATARVNGKTQAKAVA-----EAELKTESV----TQAKAGDGAMTRMHKVTYREA
--MAVTREVSKM------------------------------------------------
------------------------------------------------------------
-----------EDTTKSRVMVETKTKPLA-ERSIVPQTKSKAMPMSGV--SAVTKSEVKV
V-----------------------------------------------------------
-------AVIEANIRSYAKSH-----DKANTGSRPDR-----------------------
--------REEA------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------SIGM-----------------------------KSSDEDEENICSWFW
TGEE------------------------SSVGSWFWPEEETSLQV---------------
-----YKPLPK---------------------I-QEKP----------------------
------------------------------------------------------------
----------------------KPAHK------------------------PTLTIKQKA
-IAW----SRA--RYIVLVPIE------------GG--EQS-LPP---------EGNWTL
VETLIET--------PLGIRPLTKIPPYHGPYYQTLTE------IKKEIRQREKYGPNPK
ACHCKS-----RGFSLEPKEFDKLVALLKLTKDPFIHEIATMIMGISPAYPFTQ------
----------DIIHDVGITVMIENLVNNANVKE------HP-RALSIVDDS-SESSEEPK
SGESYIHQVCKDIVSCPLNSPVQLAGLKLLGHLSVKFDDHYVITSYIPDF-LTLLNKGSV
K-TK-FYVLKVFSCLSKNCANTRELISAK---VLSSLVAPFNKHESK----------ANI
LNIIEIFENINFQFKTKVKLFTK--------EK-FTK--SELI-SIFQEAKQFGRKLQDL
A-EHSDPEVRDKVIRLILKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------ET
DLGHIEYQGQYIGLGNIPVMAKSKTR-------------AQTN----MRKGTRRKVSGLV
SSAAKTQAKEWFQTDVRGGRKAVKNQTEQRK--STPSPMPTSKAGGDFGLWTEKE-----
-----ASRSACIESGNDVFSG-----EEASISTLFWGGEEAD------------------
----------------------------------------------DVSSSKKKVEAN--
------------------------A--------------------------------GAS
SPEELG-------------------------------IES--------------------
----MTVTD-CKP--R-----------------------------EE--KEEVIWGNWLG
DGGD------------------------TSFDLNPRSM----------------------
----STVVKPQV--------EDELDDMDRPIDW-SEVTVWPNA-----------------
-LAAILALASQLLMSKRPPS-------Y-------IALSSEEK-----------------
--------------------------------------------------ARTLPA--EE
VSLC----EGTNVCL-SIQEYP------------FD--AEICT-QTI----EEIR--HE-
LR-I-----------------------------------R------------NLNGIKPF
SCPCKM------ECCVDAEEWEKLISFLQSNAYLLIHKMAQIAMGVTEVIPFVQ------
----------QLVNEMEVLRVSRFLL-F--------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------MTRAEMEPGAQAKTENKPGDENA--------N-------TN--AAEVENEAPL
VVRPKV--------------------------RT--QIMTGARPKVKPRAPPGARPRI--
------------------------------------------------------------
------------------------------------------------E------ASSPG
GAYPKY--KPKSIPVSRSRNDA--------------Q--------------VWAPNRFR-
-----ADPMSKMGKQSHMSTANSPLVSTDS--GAIAQAKGLSVDRELGNMDTESYPRR-A
NSQAGFQHSFGPE-EGPS------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---TGTWYRSRPAPK-GEASENSDFRWADKPSGSSSFWNRDEPSTRFRPRKNMKTNNPRF
RHMAKQE-----A--NTMPRHKNKQEFYNIS-SSDSE-----------------------
-DESAKTPWFWAKEKTKVWS--RPKEEP-NNRSWFRPKKEVHA------------ESTSG
SECENHPKSSFCSGEEAKSRTKPRVRKGVNMRARHQAKREAYNDGPSGSV------DTSK
KESWFLPEDKA---------GAF-----AKSKIKKEPRTRAMPK----------------
EE----VKTKARANTKQETRS-----EEEVLVGAWFWDTQESRMVDRVITKPSLHVEEEP
IVGDWFWSEEEASVDSETCCIS-RPRAKEDQVSTFSLGSG-KKTSIENGPKATSKSLSVA
NEE-ENIIGSWFWADDEDVS---------------------------------LQAEDES
IFGSWFWGIGENS-LRS-VRVGCE-------------------------------KMMP-
KSEEKEVTDSWFWAGE-VSTEAEVEEQ----------ARPASTKGTIFVPWFWSEKQAHV
DLG------TDPCSDIMAGAE-----EEPIIGPWFWAKVDNSVEAEVNSKSSLEDEEE-P
IISPWLGAREQANMKYAAGARYKPVAEAEDTNKESCLWPK-EPSLYPTNRESSKSALREH
-----GDTVDPWLWSNNYPRTEATAG------------------------SWLWAAEEGN
IDDETGEEIKLPTLEDNIFSSWFWKDEEETVVEATNIQESRPEAEEEDIIGSWFWAGDED
KFQPATEIHEENK-TASEEEDAVGSWFWDKEE----------------------------
---ASLEPMRRGTFESAPGIKEE-----GITGSWFWSGE-ARIGAGSQT-VETGSETEEE
AIFESLIWAAKK-----NIIRPAVNRVSKPEGE-GEMV----------------------
-VESQ--SSDKAPEKSETVVISESSPEKKEGPDVEFGSSAKDEAVNKPGSGDNCEFNI--
-EAETMVGPWFWEGDETAFES-NPTPVFKATCEPMSSTEQEPDPSRRPQSWDEVTVQFKP
-GPW----GKAGFPSISPFRFPKEA-ASLFAEMFGGKPRADNLGA-E------------G
---E--PGSEFPFQYDPSY--------------------RSVQEIREHLKARDSAQPESW
SCSCVQ-----CDLRISSEEFEELLLIMDRNQDPFIHEISKIAMGMRSASPFTR------
----------DFIRNSGVISLIEALLNYPSSRA------RT-TFLENMVRV-SPPYPDLN
MIQTYVCQVCEDTFDYDLDSADQLSGLTMITHLTATSDYHKMVAKYLSGF-FYLLNSGNT
K-TR-LQVLKLLLNLSENLAMTKHLLTTE---SMSEFMALFNKEDSN----------DNV
QIVLAIFDNISKNIQKEALFADDDD---D-DEVVVNL--EPLI-SAFQEIEKIAKQLKRN
PDNQKSP-----------------------------------------------------
-------------------------------------------

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---------------------------------MGRTREAGCVAAG----------VVIG
AGACYCVYRLA--WGRDE-NEKIWD----EDEESTDT--SE-------------------
-----------------------------TGVETV------KGAKTNVGAGSGAKLQGDS
-----------------------------KV------------KPEVSLGLEDCLGVKEK
AYS----------------G--------SHSGGGLE---AKA------------------
-----------------KALFNT-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------L----------------------------------
----------------KEQASAKAGKGARVGTIS--------------------------
---------------------------------------------GNRTLAPSLPCPGGR
GG---------GCHPTRSGSRA---------------------------------GGRAS
GKSKGKARSKSTRAPA-T---------------------------TW----PVRRGKFNF
PYKID--------DILSAPDLQKVLNILERTNDPFIQEVALVTLGNNAAYSFNQ------
----------NAIRELGGVPIIAKLIKTKDPII------RE-KTYNALNNL-SVNAENQG
KIKTYISQVCDDTMVCRLDSAVQMAGLRLLTNMTVTNHYQHLLSYSFPDF-FALLFLGNH
F-TK-IQTMKLIINFTENPAMTRELVSCK---VPSELISLFNKEWDR----------EIL
LNILTLFENINDNIKNEGLASS---------RKEFSR--SSLFF-LFKESGVCVKKIKAL
A-NHNDLVVKVKVLKVLTKL----------------------------------------
-------------------------------------------

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-----------------------MVDSGTEARARGKAEAGLQDG--------ISGP----
------AAARVNGKTQAKAVA-----EAELKTESV----TQAKAGDGAMTRTHTVTYREA
--MAVTREVIKV------------------------------------------------
------------------------------------------------------------
-----------EDTTKTRVMVETKTKPLA-ERSIVPQTKSKAMPMSRV--STVTKSEVKV
V-----------------------------------------------------------
-------AVIEANIRSYAKSH-----DKANTGSRPDR-----------------------
--------REEA------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------SIGM-----------------------------KSSDEDEENICSWFW
TGEE------------------------PSVGSWFWPEEETSLQV---------------
-----YKPLPK---------------------I-QEKP----------------------
------------------------------------------------------------
----------------------KPTHK------------------------PTLTIKQKV
-IAW----SRA--RYIVLVPVE------------GG--EQS-LPP---------EGNWTL
VETLIET--------PLGIRPLTKIPPYHGPYYQTLAE------IKKQIRQREKYGPNPK
ACHCKS-----RGFSLEPKEFDKLVALLKLTKDPFIHEIATMIMGISPAYPFTQ------
----------DIIHDVGITVMIENLVNNPNVKE------HP-GALSMVDDS-SESSEEPK
SGESYIHQVCKGIISCPLNSPVQLAGLKLLGHLSIKFEDHYVITSYIPDF-LTLLNKGSV
K-TK-FYVLKVFSCLSKNHANTRELISAK---VLSSLVAPFNKNESK----------ANI
LNIIEIFENINFQFKTKAKLFTK--------EK-FTK--SELI-SIFQEAKQFGQKLQDL
A-EHSDPEVRDKVIRLILKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
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-----------------------MAGSGAKARTRGEAEAGLKAG--------ISGS----
------ANARVKAETQAKAVA-----EAEPKTELV----TQVKAGDGAIARTQTMTCTEA
--VAMTREVSNM------------------------------------------------
------------------------------------------------------------
-----------EDITKTRVMAETKTKPPSSALNQVPQTKSKAMPVSRV--SAVA-IEVRV
G-----------------------------------------------------------
-------TGSEANIRSCAKAD-----DKANVGARAG------------------------
----------DE------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------AGIGI-----------------------------KSSDEDEENVCSWFW
SGEE------------------------PSVGSWFWPEEETPPQV---------------
-----CKSLPK---------------------I-QEKP----------------------
------------------------------------------------------------
----------------------KPPPT------------------------PKLTTKQKA
-KAW----LRA--RYIVLVPVE------------GE--EQS-LPP---------EGDWTL
IDTLIET--------PLGIRPLTKIPPYDGPYFQTLAE------IKKQIKQREKYGPNPK
ACRCKS-----RAFSLEPEEFDKLVALLKLTRDPFIHEIATMTMGISPAYPFTQ------
----------DIIHDVGITVMIEYLVKNPNIKE------HP-RALSMVDDN-SESPEEPD
VGESYIHQVCKDIMSYPLNSPGQLADLKLLVHLSVNFEDHHVIANYIPDF-LTLLNKGNV
K-IK-FYVLKVFLCLSKNQANTRELISAE---VLSSLVAPFNKNESK----------ANI
LNIIEIFENINFQFKKKGKLFTK--------EK-FTK--SELI-SIFQEAKKFGQKLQDL
A-EHSDPEVRDKVIRLILKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
--------------------------------------------MGRVQEVGWVTAGLMI
WAGTCYYIYRLTKGRAQGVRRLARNGPRV-KMENMVG----IQNQTVAMCEAMAGTKIET
RPKPNTGAETGAGGRAGAEVETKDTAKARTQANSQ----AKAMAEAETETQSE-------
ATTMAETVVMTEAVTLTEAE----AYDVAMKEAVTQTDSEAGRLVKKEAVTQTK-AKAWA
LVARAETKKEAMTQTKAETRILAEKEKEVNRVMVTQNEALAVTGE----VAMMGAINKIG
IVAETKARAWEETVSVAKTQSEARSGTTVDAKGNPNTMAKAETGTDMKSCALSQVVAENQ
VDNVLGTGVEAKGNYN---------------------------TMHQAGSATDMRASVQP
QIVTKAQTEAMRGAMADVGSNANVMYKAGVGADMNISI-QSQTVIQRQAETMSGAR-VDD
RGNINVIYRAMTGADMWASAQLQAVASAQAE-----------------------------
---AMLDARVMGRVNPNSISKVGFGIDIESYT-QHQPTATVQADALLDDKIKAQGNANTK
SKEEAGTDTKAQSQISTKSYAEALPSTRGKSRGKAKGKCKAGVGTDVKTCVQPQGGAKTQ
VDVLPDSRVDGRGDPDAMSMVEAKAEPRAGGQPQDMAGSQGEAMPGAKNKVQDYLNTISK
SGAGLHTKSSAQPQAMTN---------------------------------------TQG
EALAGVKNKVRGNPNAVSKAGTGPDTKFDSA---QL------------------------
--QADTIGSPQPQGVASFQGEVSPGTKNKVRGNPNAVSKVWTGTDTK-------------
---------------------------SSAQPQAMANFQGEALPSVKNKVRGNPNAVSKA
GTGPDTKFDSAQPQV------------------------------DTIVSAQTQAVVNFQ
GEASSGTKNKVRGNLSAVSKVWTGSDTKGSAQPRTDTTGSAQPQAVACSWG---------
-------------------------------ESLPATKNKVRGNPSAMSKVGSGPDTTCS
AQP------------------------------QTDTTNSAQPQAVANSQGEVLLGAKSK
VRGNPNDVSKAESGTD------IMGSARSQAEALSGARNKVRGNLSAVSKVGLGSDTKSS
AHPQSAATSQGEALCGIKNKVRGNPSAVSKAG-----SRPDTKGSAHPQAVANSQGEALS
GTKNKVRGNSNAVSKAGTGSDTIDPAQPPTD-----------------------------
---KTSSAQPQAVACSQGEVLLGARSKVRGNPNAVSKAGIGADSIGSAPSQAVASSHGEA
LLGARSKVRGNRVAESKAEAGAALMGSGQ--RQSVTHSQSKSGAKDKTIHKSEAEATGDV
SVKPKA----KATPTSESEDGADTQACRKSQPKVHDYYWSGIGVEDWIASERWIKFRFQA
RDGYWENSMSWADDENET--------------------------------SVESWSGARS
ENEVGIQSWAGVG-DQASGGLWAGSHASQQSWAGGQASGGYWVETGDKAVGGSWTVAENQ
ASGGSWAGTGNQAVGVPWAGAQASESSWAGGQTSGVSWAGGEAIGVSWTV--------VE
NQANGVSWAGAQEQASGRSQDGTGIQANAGPWAQATTGNVVNIGYWAVAVDQATG-GSWI
LTSDLSGGASWVGTSDLSGAISKPRLQDQAHESVSWAGAG--------LGPEGQSSGRIW
AGTTDQASGGSRLGPVDQSSSGSWVMAGEQASEGSRPGFADQSSVGSWAGTGNQASEGFL
VGAVDQASGGSWTGTVDQSGGGAKPRFEDQVSEEG-SLASAGGQAGGGSRSQPEDQSSGG
SWADSGDQASRGFLVGAVDQANEVSWAEP----GHQAGGEAKLRSEDQAKSGNVSWADSG
GQVSGGSTLVPRDQSVGDSWAGIGDQASGGPRPVPEAQSTGWY-------------YAYS
G---NHASVGGSWAGAGGQVIGGLGLGLMNPSSGGSWAVTGNQVSGASWAGA--VGQAVS
CSKPGFEDQASAGAFWSGAEDQATGGSSPTSADQSDQSSGGSWAGSGSQTSGQSWVVAGD
QASSCSKPGFEDQASAGAFWSGTE-----DQATGGYSPASADQSDQPSGGSWAGGG---S
QANGQSWVVAG--DQ-AGSCSKPGFEDQ-ASGGAFWSGVED-------------------
----QAT-----G--GSSPGSADQ--PSGGS-WAGGGSQASG--QSW--------VVAG-
---DQAGSCSKPG----------FEDQASAGAFWSGAVDQATGGSSPGSADQPSGGSWAG
GGSQASGQSWVVAGDQAGSCSKPGFEDQASAG----------------------------
---------------------AFWSGAEDQATGGSSPGSADQPS--GGSWAGGGSQ----
-----------------------------------------------------------A
SGQSWVVAGDQAGSCSKP----------------------------------GF------
EDQ---ASAGAFWSGAVDQATGGS------------------------SPGSADQP----
SGGSWAGGGSQA-SGQSWVVAGDQAGSC---------------------------SKPGF
EDQAS-GGGSWTGSGDQAGRKSWAGSRPGKEASRGSSLGPDEQAS--GGSWARARDQTSG
RSQ--VSARMEANEGSWLGAG-----SEASTGSWFWRGEESG----IVSSPGGKN--E-A
SIESNSGVGEEAVISSR----------FRAEN----------------------------
------------------------------------------------------------
----------------------------------------------KANIGCWIRS----
--NEATCMDSCLGAE---------------------------------SGTEVRQESWLW
DGDA------------------------ATTGSRLGAGEEADM-----------------
---GSWTLAED------V-DEDEVSRASSP-DI-EEIS----------------------
-LRSLFWAESENSNEFRSN--------REKN--VNFQQGAENKT-STKDKLEA-------
-AGGVDVKSCFWDSNENKSEE-KYVPKTKAKKSAE-S----------RVTYPSM-VPGAG
MGSW----AGAMIWTEMK--FP------------YQ--NESCFPPED----E-----LR-
KQ-I-----------------------------------RS------------GEKIQPW
ACRCKR------ETNMDPQELEKLICMIEMTEDPSIHEIANNALYNSPDYPFSH------
----------EVIRNAGRISIIEGLLNNPYPSV------RQ-KALNALNNI-SVAAENHR
KVKTYLNQVCEDTITYPLNSNVQLAGLRLIKHLTIISEYQHMVTNYISEF-LRLLTVGSG
E-TK-DHILGMLLNFSKNPSMTKDLLIAN---APASLINIFSKKETK----------ENI
LNALSLFENINYHFKRRAKVFTQ--------DK-FSK--NSLY-FVFQRPKACAKKLRVL
AAEYNDPEVKERVELLLSKL----------------------------------------
-------------------------------------------

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---------------------------------------MTGAKN--EGRKKAKAQKR-A
GAQGE--AKRESTGV------VRPV---------------------AKTQDKAVAKAGSQ
-----ADAA---------------------------------------------------
------AATKAR-------------SKNKTVTEIKERALANFSPKAEDEATR---VSGIC
SV---AEA----------------------------NAEP-----RSTCKDKAGVDTWFW
AGEE------------------------ASVGSWFWNGEEAGN-RSSA------------
---------MDEDK-------AGIGPQSCA----E-------------------------
------------KLEPVAGASCKARPGTDEE-----------------------------
EEEENVIGNWFWDGDETSFDP-NPKPVSRIVRPQP---VDEINEKNRPKDWSEVTIWPKA
PAVTP---AVLGFRSQVPFETKPPS----YIVLASAEENTQSLPVA-----T--TCPSRS
TASCSQSVPEYPFGSDPCI--------------------QTIEEIRRQIRIREVNGIKPF
ACPCKM------ECYMDSEEFEKLVTLLKSTTDPLIHKIAQIAMGIINVHPFAQ------
----------EFINEVGVVTLIESLLSFPSSEI-------RKKAVITL-NP-PSGDERQR
KVELHVKHMCKETMSFPLNSPGQQSGLKILGQLTAESNHHHIVANYFSEL-FHLLSLGNR
K-TR-NLVLKVLLNMSENPAAARDMINTK---ALAALKLIFNQKEAK----------ANL
VSAVAIFINIKEHIRKGSIVVVD----------HMSY--NTLM-AIFREVKVIIETM---
------------------------------------------------------------
-------------------------------------------

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--------------------LQKLIHLLQATDDPLIQEQALITLSNSAAFSVNQ------
----------DVIRNLDGLSVIGGMLSNCVPKV------KE-KALNALNNL-SMNIKNQE
EIQVFITQVCRTVESAPLNSDVQLAGLRLLTNMSVTSDYHQKMINSIPCF-LHLLSEGTE
R-TQ-IQVLKVLVNLSANPAMTVHLLRAQ----V--------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------

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---------------------------------MGGPRGAGWVAAG----------LLLG
AGACYCIYRLT--RGRRR-GDR---------ELGMRP--SK-------------------
------------------------------------------SAGET-------------
------------------------------------------------------------
--A----------------G--------CPAGGVLE---EG-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------TS-------------------------------
------------------KGQ-L----CGRS--------------AR---------P-QR
GG---------------TWESQ------------WSKTSQ--------------------
-----------PE--------------------------------------------DLT
DGSYD--------DVLNAAQLQKLLYLLESSEDPVIIERALITLGNNAAFSVNQ------
----------AIIRELGGIPIVGNKINHSNQSI------KE-KALNALNNL-SVNVENQI
KIKIYINQVCEDVFSGPLNSAVQLAGLRLLTNMTVTNDHQHMLHNYITDL-FQVLLTGNG
N-TK-VQVLKLLLNLSENPAMTEGLLHAQ---VDSSFLSLYDSHVAK----------EIL
LRVLTLFQNINNCLKIEGHLAV---------QPTFTE--GSLFFLLHGE--ECAQKIKAL
V-DHHDAEVKEKVLTIIPKI----------------------------------------
-------------------------------------------

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------------------------------------------------------------
-----------------------MVDSGTEARARGKAEAGLQDG--------ISGP----
------ATARVNGKTQAKAVA-----EAELKTESV----TQAKAGDGAMTRMHKVTYREA
--MAVTREVSKM------------------------------------------------
------------------------------------------------------------
-----------EDTTKSRVMVETKTKPLA-ERSIVPQTKSKAMPMSGV--SAVTKSEVKV
V-----------------------------------------------------------
-------AVIEANIRSYAKSH-----DKANTGSRPDR-----------------------
--------REEA------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------SIGM-----------------------------KSSDEDEENICSWFW
TGEE------------------------SSVGSWFWPEEETSLQV---------------
-----YKPLPK---------------------I-QEKP----------------------
------------------------------------------------------------
----------------------KPAHK------------------------PTLTIKQKA
-IAW----SRA--RYIVLVPIE------------GG--EQS-LPP---------EGNWTL
VETLIET--------PLGIRPLTKIPPYHGPYYQTLTE------IKKEIRQREKYGPNPK
ACHCKS-----RGFSLEPKEFDKLVALLKLTKDPFIHEIATMIMGISPAYPFTQ------
----------DIIHDVGITVMIENLVNNANVKE------HP-RALSIVDDS-SESSEEPK
SEESYIHQVCKDIVSCPLNSPVQLAGLKLLGHLSVKFDDHYVITSYIPDF-LTLLNKGSV
K-TK-FYVLKVFSCLSKNCANTRELISAK---VLSSLVAPFNKHESK----------ANI
LNIIEIFENINFQFKTKVKLFTK--------EK-FTK--SELI-SIFQEAKQFGRKLQDL
A-EHSDPEVRDKVIRLILKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
---------------------------------MGGPRGAGWVAAG----------LLLG
AGACYCIYRLT--RGRRR-GDR---------ELGIRS--SK-------------------
------------------------------------------SAGGT-------------
------------------------------------------------------------
--A----------------G--------FPAGA-LE---EG-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------TS-------------------------------
------------------EGQ-L----CGRS--------------AR---------P-QT
GG---------------TWESQ------------WSKTSQ--------------------
-----------PE--------------------------------------------DLT
DGSYD--------DVLNAEQLQKLLYLLESAEDPVIIERALITLGNNAAFSVNQ------
----------AIIRELGGIPIVANKINHSNQSI------KE-KALNALNNL-SVNVENQI
KIKIYISQVCEDVFSGPLNSAVQLAGLRLLTNMTVTNDHQHMLHSYITDL-FQVLLTGNG
N-TK-VQVLKLLLNLSENPAMTEGLLRAQ---VDSSFLSLYDSHVAK----------EIL
LRVLTLFQNIKNCLKIEGHLAA---------QPTFTE--GSLFFLLHGE--ECAQKIRAL
V-DHHDAEVKEKVVTIIPKI----------------------------------------
-------------------------------------------

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------------------------------------------------------------
---------------------------------MGRTREAGCVAAG----------MVIG
AGACYCVYRLT--WGKDE-NEKIWD----DDDDDDDD--DDEEE----------------
--------------------------EEESSDKPE------KGSKTNIGVGAGTQS-PGD
------------IEAR--------PEVNLGP------------ES--------DPGVKKE
AHL----------------G--------SQSGGGLE---AKA------------------
------------------------------------------------------------
-------KALFNI-----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------L-KE--------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------QASAKAGKGVRVGNI---------------------------
-----------SG---------------------------------NRTLAPSLPCPGGR
GG---------GCHPTKA--R-------------A--------------------GSRSS
GKSKGKSRSKSTRVPA-T---------------------------TW----PVRKGKFNF
PYKID--------DILSAPDLQKVLNILERTNDPFIQEVALVTLGNNAAYSFNQ------
----------NAIRELGGVPIIAKLIKTKDPII------RE-KTYNALNNL-SVNAENQG
KIKTYISQVCDDTMVCRLDSAVQMAGLRLLTNMTVTNHYQHLLSYSFPDF-FALLFLGNH
F-TK-IQIMKLIINFTENPAMTRELVSCK---VPSELISLFNKEWDR----------EIL
LNILTLFENINDNIKSEGLASS---------RKEFSR--SSLFF-LFKESGVCVKKIRAL
A-NHNDLVVKVKVLKVLTKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
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-----------------------------------------------MGRARE--VGWMA
AGLM----IGAGACYCVYKLTI------------GR--DDSEKLEE------EEEEEWDD
DQELDEEEPDIWFDIETMARPWSEDGDWTEPGAPGGTEDRPSGGGKANRA--HPIKQRPF
PYEHK--------NTWSAQNCKNGSCVLDLSKCLFIQGKLLFAEPKDAGFPFSQ------
----------DINSHLASLSMVRNTGPTPDPTV------R--EALCATDNL-NASIESEG
QIKMYINEVCQETVSHCCNSFLQQAGLNLLISMTVINN---MLAKSVSDLKFPLISEGSG
C-AK-VQVLKPLMGLSEKPVLAGELVGAQ---MLFSFMSLFIRKGNR----------EIL
LETPAP------------------------------------------------------
------------------------------------------------------------
-------------------------------------------

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------------------------------------------------------------
---------------------------------MSRARDAGCVAAG----------IVIG
ASAWYCVYKYT--RGRDQ-KKRRPA----KSKNRA--SVGTGTRARAGLRSGFTIDLGPG
FNPPTPASVEAMNK-SQEEASTLTTSAAGEMVPAA------PSPKTRNGAESKVQEANGA
--GTKPTTMESAVPTSAASAVTHTPKMAQVP------------TAAEATKIVVAPKVAEA
PRS----------------I--------EAAGAIAP-LGPAVPLGVVQAPGPAIPS----
-----------------PSIAPTM--------------SAAI------------------
---------PWAVA----------------------------------------SPGVAQ
SPGPA----------APTMAV---QSLVPAAPSWAVVAP---------------------
-----------------PGAVYIPVAAHF-----------TGAAAAT----RVTQSPGTV
VPPLPPPSLGAAMLSRAVQSPVATVPPRAVQSPGATVHSGAAQSPGVVVPSRAVQYSGAT
VPTMTGAPSGTSVPPRGPTTPQ---GAAF------------ARAPASTQRASTTEVMQVP
GVAAPTNATQTPRVTTP------------------------------AMVAGASLP----
----M-----------ISGAA-----------------E-TP------------------
----------------------GTSGSSK-------------------------------
-----------TAA-----TGKKATPGAHTGAIPKAG-----------------------
-----------SGGNRNRNGG-K----GKNR-------------K-NKVEVDELGMGFRP
GD---------GAAAAAAASAN------------GGQAFLAEIPES-----EEGESGWTD
TESDSDSEPEVQQRGKG----------------------------KR----TIPMHKRPF
PYEID--------EILGARDLRKVLALLQKSDDPFIQQVALLTLSNNANYSCNQ------
----------ETIRKLGGLPIIANMINKTDPHI------KE-KALMAMNNL-SENYENQG
RLQVYMNKVMDDIMASNLNSAVQVVGLKFLTNMTITNDYQHLLVNSIANF-FRLLSQGGG
K-IK-VEILKILANFAENPDMLKKLLGTQ---VPSSFSSLYNSYVES----------EIL
INALTLFEIIFDNLRAEVFN-----------YREFNK--GSLFY-LCTTSGVCVKKIRAL
A-NHHDLLVKVKVIKLVNKF----------------------------------------
-------------------------------------------

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-------MTGAEIESGAQVKPEKKPGEEVV--------G-----------GAEIENDVPL
VVRPKV--------------------------RTQAQIMPGARPKNKSKVMPGASTKV--
------------------------------------------------------------
------------------------------------------------E------TSAVG
GARPKS--KAKAIPVSRFKEEA--------------Q--------------MWAQPRFG-
-----AERLSKTERNSQTNIIASPLVNTDS--VLVAKTKYLSEVRELVNTDTESFPRRKA
HYQAGFQPSFRSK-EETN------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
---MGSWCCPRPTSK-QEASPNSDFKWVDKS-VSSLFWSGDEVTAKFHPGNRVKD-STRS
RHMANQE-----A--NTMSRSQTNQELYIAS-SSGSE-----------------------
-DESVKTPWFWARDKTNTWS--GPREDP-NSRSRFRSKKEVYV------------ESSSE
SEHEDHLESWFGAGEEAKFRSKMRAGKEANNRARHRAKREACIDFMPGSI------DVIK
KESCFWPEENA---------NTF-----SRPMIKKEARARAMAK----------------
EE----AKTKARARAKQEARS-----EEEALIGTWFWATDESSVADEASIESSLQVEDES
IIGSWFWTEEEASMGTGASSKS-RPRTDGEPTGDSLFGAR-EKTSMKTGAEATSESILAA
DDE-QVIIGSWFWAGEE-VN---------------------------------QEAEEET
IFGSWFWVTDAAS-VESGVGVSCE-------------------------------SRTR-
-SEEEEVIGPWFWSGEQVDIEAGIGEE----------ARPGAEEETIFGSWFWAENQTYM
DCR------AETSCDTMQGAE----EEEPIIGSWLWTRVEACVEGDVNSKSSLEDKEE-A
MI-PCFGAKEEVSMKHGTGVRCRFMAGAEETNNKSCFWAEKEPCMYPAGGGSWKSRPEEE
-----EDIVNSWFWSRKYTKPEAIIG------------------------SWLWATEESN
I-DGTGEEAKLLTEEETIINSWFWKED-EAISEATDREESRPEAEEGDIIGSWFWAGEEN
RLEPAAETREEDRLAAEKE-GIVGSWFGAREQTIRREAGSCSKSSPKAEEEEVIIGSWFW
EEEASLEAVAGVGFELKPGTEEE----EITVGSWFWPEEEASIEAGSQAVEEMESETEEE
TIFGSWFWDGKE-----VSEEAGPCCVSKPEDD-EEMI----------------------
-FESWFWSRDKAIKETATVATCESKPENEEGAIAGSWFEAEDEVDNRTDNGSNCESRTLA
DEDEAIVGSWFWAGDEAHFES-NPSPVFRAICRSTCSVEQEPDPSRRPQSWEEVTVQFKP
-GPW----GRVGFPSISPFRFPKEA-ASLFCEMFGGKPRNMVLSPEG----E--DQESLL
QPDQ--PDPEFPFQYDPSY--------------------RSVQEIREHLRAKESAEPESW
SCNCIQ-----CELKIGSEEFEELLLLMEKIRDPFIHEISKIAMGMRSASQFTR------
----------DFIRDSGVVSLIETLLNYPSSRV------RT-SFLENMIRM-APPYPNLN
MIQTYICKVCEETLAYSVDSPEQLSGIRMIRHLTTTTDYHTLVANYMSGF-LSLLATGNA
K-TR-FHVLKMLLNLSENLFMTKELLSAE---AVSEFIGLFNREETN----------DNI
QIVLAIFENIGNNIKKET-VFA---------DDDFNL--EPLI-SAFHKVEKFAKELQGK
TDNQNDPEGDQEN-----------------------------------------------
-------------------------------------------

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---------------------------------MGYARKVGWVTAG----------LVIG
AGACYCIYRLT--RGRKQSKEK-MA----EGGSGDVD--DSG----------------DC
---------------------------------------------------------SGA
--RYNDWSDDD-------------------------------------------------
DDS----------------N--------E-------------------------------
------------------------------------------------------------
-SKSIVWYPPWAR-----------------------------------------------
------------------------------------IG----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------T--------------------------------
-----------EAGTRARARA---------------------------------------
------------------------------------------------------------
-------------RARAT---------------------------RA----RRAVQKRAS
PNSDD--------TVLSPQELQKVLCLVEMSEKPYILEAALIALGNNAAYAFNR------
----------DIIRDLGGLPIVAKILNTRDPIV------KE-KALIVLNNL-SVNTENQR
RLKIYMNQVCDDTITSRLNSSVQLAGLRLLTNMTVTNEYQHMLANSISDF-FRLFSAGNE
E-TK-LQVLKLLLNLAENPAMTRELLRAQ---VPSSLGSLFNKKENK----------EVI
LKLLVILENVNDNFKWEENEST---------QIQFGE--GSLFF-FLKEFQVCADKVLGI
E-SHHDFLVKVKVGKFMAKLTEHMFPKSQE------------------------------
-------------------------------------------

------------------------------------------------------------
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---------------------------------MSRVRDAGCVAAG----------IVIG
ASAWYCVYKYA--RGRNQ-MKKRLA----KPKTRA--VAGTGARARAGLRAGFTIDLGPG
FGPPTPVHTGAEVV-Q--DESALDMAGAEAVAPAA------SSXXXXXXXXXXXXXXXXX
--XXXXXX-XXXXXXXXXXXXXXXXXXXXXX------------XXXXXXXXXXAPKLAEA
PGT----------------A---------------EAPGAPAPTEA-AP-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------PTEAVEASI------------PATPT---------
---------VVA---ALS------------------------------------G-----
-ATASSGAAAPSGAAVP------------------------------SG-----AA----
---AP------------TGAA-----------------E-AP------------------
----------------------GTSGSSK-------------------------------
-----------T-----AAAAKKTTPGAHTGAIPKAGS--ATGA---VPKGGA-------
-------K----GGTKSRTGG-K----GKGK-------------K-NKVEVDELGLGFRP
GD---------GAAAAAAASAN------------GGQAFLAEVPDS-----EEGESGWTD
TESESDSEPETQQRGRG----------------------------KR----PVPMQKRPF
PYEID--------EILGVRDLRKVLALLQKSDDPFIQQVALLTLSNNANYSCNQ------
----------DTIRKLGGLPIIANMINKTDPHI------KE-KALMAMNNL-SENYENQG
RLQVYMNKVMDDIMASNLNSAVQVVGLKFLTNMTITNDYQHLLVNSIANF-FRLLSQGGG
K-IK-VEILKILSNFAENPDMLKKLLSTQ---VPSSFSSLYNSYVES----------EIL
INALTLFEIIYDNLRAEVFN-----------YREFNK--GSLFY-LCTTSGVCVKKIRAL
A-DHHDLLVKVKVIKLVDKF----------------------------------------
-------------------------------------------

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---------------------------------MGYARKVGWVTAG----------LVIG
AGACYCIYRLT--RGRKQNKEK-MA----QGVSGDVD--DVG----------------GC
---------------------------------------------------------PGA
--RYNDWSDDD-------------------------------------------------
DDN----------------S--------E-------------------------------
------------------------------------------------------------
-NKGIVWYPPWAR-----------------------------------------------
------------------------------------IG----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------T--------------------------------
-----------EAGTRARARA---------------------------------------
------------------------------------------------------------
-------------RARAT---------------------------RA----RRAVQKRAS
PNSDD--------TILSPQELQKVLCLVEMSEKPYILEAALIALGNNAAYAFNR------
----------DIIRDLGGLPIVAKILNTRDPIV------KE-KALIVLNNL-SVNAENQR
RLKIYMNQVCDDTITSRLNSSVQLAGLRLLTNMTVTNEYQHMLANSISDF-FRLFXXXXX
X-XX-XXXXXXXXXXXXXXXXXXXXXXXX---XXXXXXXXXNRKENK----------EVI
LKLLVIFENINDNFKWEENEST---------QNQFSE--GSLFF-FLKEFQVCADKILGI
E-SHHDFLVKVKVGKFMAKLAECMFPKSQE------------------------------
-------------------------------------------

------------------------------------------------------------
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---------------------------------MSRVRDAGCVAAG----------IVIG
ASAWYCVYKYT--KRTNQ-TKKRLA----KSKTRA--VTGTVTRARAGLRAGFTINLGPG
FGPPTLVHSRAEDK-AQDEASALDGAGAEAEAPPV------SSAEAQSGSGRQAQEAEGS
--RVGPKA-ESVVEAEVTSTMAPPPREAEAL------------MAAEAL------KLAEA
PGT----------------A--------EAPGVPVVPPGMPVPTEA-AAP-----T----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------EMAETPX------------XXXXX---------
---------XXXXXXXXXX-----------------------------------------
----XXXXXXXXXXXXX------------------------------XX-----XX----
---XX-----------XXSAA-----------------E-VP------------------
----------------------GTSGSPK-------------------------------
-----------TSA-----AAKKATLGAHTGAIPKAGS--VTGA---VPKGGT-------
-----------KGGTRSRTGG-K----GKGK-------------KNNKVDVDELGLGFRP
GD---------GAAAAAAASAN------------GGQAFLAEVPDS-----EEGESGWTD
TESESDSEPETQQRGRG----------------------------RR----PVPMQKRPF
PYEID--------EILGVRDLRKVLALLQKSDDPFIQQVALLTLSNNANYSCNQ------
----------DTIRKLGGLPIIANMINKTDPHI------KE-KALMAMNNL-SENYENQG
RLQVYMNKVMDDIMASNLNSAVQVVGLKFLTNMTITNDYQHLLVNSIANF-FRLLSQGGG
K-IK-VEILKILSNFAENPDMLKKLLSTQ---VPSSFSSLYNSYVES----------EIL
INALTLFEIIYDNLRAEVFN-----------YREFNK--GSLFY-LCTTSGVCVKKIRAL
A-DHHDLL----------------------------------------------------
-------------------------------------------

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-------------MLHRLPR-------AGK-------MG---E-----------------
--------------------------------------------------WRRLRAAVLG
LVLS----AGAYYCYCLWRRA-------------AG--RGRRRGA---------------
------------------------------------------------------PRVPP-
---SVMEEIPPSSHSMDADALQKLIHLLKATDDPLIQEQALIALSNSAAFSVNQ------
----------EIIRNLGGLSVIGGMLLDCAPAV------KE-KALNALNNL-SMNIKNQE
EIQVYIMQVCKNIESAPLDSDLQLAGLRLLTNMSVTNAYHYKMINKIPCF-LHLLSEGSE
R-TQ-IQVLKVLVNLSANPATRRHFLKAQ---V-PSLLSFFDNCINR----------DIL
LRALVFAANLKKNVNNEDGITTE--------DE-YSE--DSVFSMLCRDSAAFAQKLASL
L-HHPDTDVKEQVVRILTQ-----------------------------------------
-------------------------------------------

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--------------------MTEVLLGAQ---VDSSFVSLYDGHVAK----------EIL
LRVLTLSQNINNCLEK-GSLAV---------QPTFPK--GSLFFLLYGE--ECAQKMRAL
A-KHHDADVKEKVTVIPRF-----------------------------------------
-------------------------------------------

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-------------MICRLDSAVQMAGLRLLTNMTVTNHYQHLLSYSFPDF-FALLFLGNH
F-TK-IQTMKLIINFTENPAMTRELVSCK---VPSELISLFNKEWDR----------EIL
LNILTLFENINDNIKSEGLASS---------RREFSR--SSLFF-LFKESGVCVKKIRAL
A-NHKDLVVKVKVLKVLTKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
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---------------------------------MGRTREAGCVAAG----------VVIG
AGACYCVYRLA--WRRDE-SEKIWD----EDDEDDEE--ESSDIS---------------
----------------------------ETGVQTG------EGANAGVGAAA---RLQGD
--SKAR------------------TEVA--------------------VELKSGPDVKVE
AHS----------------W--------AQSGGGLE---AKA------------------
-----------------KAL----------------------------------------
----------FS------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------TL----------------------------------
----------------KEQASTKAGKGARLGTIS--------------------------
---------------------------------------------GTRTLAPSLPCPGGR
GG---------GCHPTRSGARA---------------------------------GSRAS
RKSKGRTRAKSTRTPA-T---------------------------AW----PVRRGKFNF
PYKID--------DILGATDLQKVLNILERTNDPFIQEVALVTLGNNAAYSFNQ------
----------NAIRELGGLPIIAKLIKTKDPII------RE-KAYNALNNL-SVNAENQG
KIKTYISQVCDDTMICRLDSAVQMAGLRLLTNMTVTNHYQHLLSYSFPDF-FALLFLGNY
F-TK-IQIMKLIINFTENPAMTRELVSCK---VPSELISLFNKEWDR----------EIL
LNILTLFENINDNIKNEGLASS---------RKEFSR--SSLFF-LFKESGVCVKKIKAL
A-NHNDLVVKVKVLKVLTKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
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---------------------------------MGGARDVGWVAAG----------LILA
AGACYCFYKLT--RGRRR-GGR---------RLRLRP--SR-------------------
------------------------------------------SAE---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------DLT
SGSYD--------DTLNAEQVQKLLYLLESTEDPIIIERALVTLGNNAAFSANQ------
----------IVIRELGGIPIVGSKINNPNQSI------KE-KALNALNNL-SVNVENQI
KIKVYVSQVCEDVISGPLNSAVQLAGLRLLTNMTVTNAHQDMLSSYITDL-FHVLVTGNG
S-TK-VQVLKLLLNLSENPAMTDQLLDAQ---VDSSFLSLLDGHVPK----------EIL
LRALTLLQNITNCLSEERRLAT---------QPAFPA--GSLFSLLYGK--ECAQKMKAL
V-HHHDADVKEKVCF-SKK-----------------------------------------
-------------------------------------------

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---------------------------------MGGPRGAGWVAAG----------LLLG
AGACYCIYRLT--RGRRR-GDR---------ELGIRS--SK-------------------
------------------------------------------SA----------------
------------------------------------------------------------
-------------------------------GA-LE---EG-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------TS-------------------------------
------------------EGQ-L----CGRS--------------AR---------P-QR
GG---------------TWESQ------------WSKTSL--------------------
-----------PE--------------------------------------------DLT
DGSYD--------DVLNAEQLQKLLYLLESTEDPVIIERALITLGNNAAFSVNQ------
----------AIIRELGGIPIVANKINHSNQST------KE-KALNALNNL-SVNVENQI
KIKIYISQVCEDVFSGPLNSAVQLAGLRLLTNMTVTNDHQHMLHSYITDL-FQVLLTGNG
N-TK-VQVLKLLLNLSENPAMTEGLLRAQ---VDSSFLSLYDSHVAK----------EIL
LRVLTLFQNINNCLKIEGHLAV---------QPTFTE--GSLFFLLHGE--ECAQKIRAL
V-DHHDAEVKEKVVTIIPKI----------------------------------------
-------------------------------------------

------------------------------------------------------------
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---------------------------------MGYARKVGWVTAG----------LVIG
AGACYCIYKLT--RGRKQNKEK-MA----EGGSGDVD--DAG----------------DC
---------------------------------------------------------SGA
--RYNDWSDDD-------------------------------------------------
DDS----------------N--------E-------------------------------
------------------------------------------------------------
-SKSIVWYPPWAR-----------------------------------------------
------------------------------------IG----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------T--------------------------------
-----------EAGTRARARA---------------------------------------
------------------------------------------------------------
-------------RARAT---------------------------RA----RRAVQKRAS
PNSDD--------TILSPQELQKVLCLVEMSEKPYILEAALIALGNNAAYAFNR------
----------DIIRDLGGLPIVAKILNTRDPIV------KE-KALIVLNNL-SVNAENQR
RLKVYMNQVCDDTITSRLNSSVQLAGLRLLTNMTVTNEYQHMLANSISDF-FRLFSAGNE
E-TK-LQVLKLLLNLAENPAMTRELLRAQ---VPSSLGSLFNKKENK----------EVI
LKLLRSICLHILEFV------------------------NILFC-FLYYY----------
------------------------------------------------------------
-------------------------------------------

------------------------------------------------------------
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---------------------------------MGYTRKVGWVTAG----------LVIG
AGACYCIYRLT--RGRKQNKEK-MA----EGGSGDVD--DAG----------------DC
---------------------------------------------------------SGA
--RYNDWSDDD-------------------------------------------------
GDT----------------N--------D-------------------------------
------------------------------------------------------------
-SKSIVWYPPWAR-----------------------------------------------
------------------------------------IG----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------T--------------------------------
-----------EAGTRARARA---------------------------------------
------------------------------------------------------------
-------------RARAT---------------------------RA----RRAVQKRAS
PNSDD--------TILSPQELQKVLCLVEMSEKPYILEAALIALGNNAAYAFNR------
----------DIIRDLGGLPIVAKILNTRDPIV------KE-KALIVLNNL-SVNAENQR
RLKIYMNQVCDDTITSRLNSSVQLAGLRLLTNMTVTNEYQHMLANSISDF-FRLFSAGNE
E-TK-LQVLKLLLNLAENPAMTRELLRAQ---VPSSLGSLFNKKENK----------EVI
LKLLVVFENLNDNFRWEENEPT---------QNQFGE--GSLFF-FLKEFQVCADKVLGI
E-GHHDFLVKVKVGKFMAKLAEHMFPKIQE------------------------------
-------------------------------------------

------------------------------------------------------------
--------------------------------------------MGRVQDVGWATAGLVI
WAGTCYCIYRLTKGRTQSVSGHARNGSRI-ETETVVG----EQNQTLATSEAMAGREAET
RVK--TEPETGEGGEPVAEVDSKVPVLVRSSGNCQ----AKTMLEEEIETQSV-------
TSSLVETMVMTEAVTLTEST--SQAKEVTMKEAVTQTDAEAETVGKKEAVTQTK-AKAWA
MAGRAEVKKEAMTQTKAEARTLAEKETEINRVTVTQSEVLAVTKE----VVKIGTMNETG
VVAEAMIRPLEETVSVTRTQSEARLDAAVDTKENLNDMSVVVTGVDTKSYAQSQAVAIIQ
NDDMAGAEAD-KEDLK---------------------------NMSKAGSGVDMKASGQP
QIAANSLAEAVPGAKTDAWDNAKDICEAE--ADIRTCLIQSETVAKIETEATSSAT-MDG
GKDAN--VKAMTDANVTD-TQPQAVTSDQTEAMPDAKVKGKGNASAMAKAGAKANSKTSL
QTDALPDTGDKNRSDNNVTAKAEAGIDMVSCT-QTEPVANVQGDDLPDGKIKAKDNANTT
SKEGAQA--------TAQSQGEALPNTKGKARGKAKAKCKAAAGTDTKTCAQPQAGTKTQ
AEALSDSKVDSKSDSNAVSKAGAKADQKASGQPQPVLSGQNEALPGTKNKVKGNPNPMPK
TEAGTATTSSAQT-----------------------------------------------
------------------------------------------------------------
------------NVT-SSQGETTPGAKNKAKGNRNSVPKAGAGPDT--------------
--------------------------TGSAQSQTVANSHSEAFPGAKNKVKSNPNVVPKA
EAGVGACPQSV-------------------------------------------------
------------------------------------------------------------
--------------------------AASQGTAATGTKTKVKGNSSAVSKPDAGAGTM--
------------------------------------------------------------
----------------------------------------------------------GS
AHAKTVANSQGETLPGSKNKVKGNSNAVPKAEG---TTGAGTTDPNQSQ------AEALL
GARNKVRGNSNSVPKAESGASTILA-----LASSQAEALLGARNKVRGS--SNAAPKAEA
GVGARGSAQSQAVVSSQSEALLGARNKIRSNA--GTKSGARTGTRGSAQPQAVVSSQNEA
LLGARDKG----------------------------------------LSSSQVEATVDN
RVYAKPM--AGAVPTSEMVTVA------GAQPNVHDYYWNGIGVEDWIAAERWIKFRFQT
IDGDWENSVSWTEDESGASIGPWTGAANDK--AGIVSSWAVAC----DETSIKSWTGARP
ENEVALGSWVSAG-DQATGAIWAGAQTSDGTWVAD------------KASGGSWTGAENQ
ISAGSWVVSGNQAIAGPWAVSQVTDGSWPAVQASGVSWVVDQATG-TWTV--------AE
NQTGAVSWAGA--------------------------GNIVSIGYWTGAVDQTNA-VSWT
GT------------TDQVGVEAKPRFEDQASEKGSWVVAGVQTSGETRLGSEDQSSGRSW
TETVDQANVASRLGTVDPASGTSWAGTGDQVGGVSTSGSADQSSSGSWAGTRNL------
------AGERSWTGTGDQSDGAAKPGFENQTSNEG-SWAGTIGQPSGGSKSVSEAQSAGR
SWADSADQLSGGFLVGPLDQANGESQPVS----GELAASG-----VDQTSGGGCWT-GSG
DQSGGESRLGPRDQSNGESWPGTGDQTGG------------WY-------------CTYT
G---TQTIGGGPWVGASGQDVGGPKPVHMNQATGGAWLGTGTQVSAVPWTGD----QVSG
CPKPGFEDQAIGGGFWAGAGDQTTGGSRPAVSED-QSSGGVSWGGAGGHVI---------
------------------------------------GGSR---TDQSSGTSWPGMG---S
QVSGGSWIGTV--DQ-TSGCTKSGFEDQ-TCGGGSWVGTGDQTSGESWPGSRASNE----
---ASGG-----S--RL-----------------DPQ-----------------------
--------------------------DQGSGGSWIRSEDQASGRFLVSAEVEANEGFWFG
PGSEAFIGSWCWTEE-ATILPVAGMKDEASTESTSGTREETSISSGLGDE------KKTS
SESWTRSEETA--------FTGTCDGGEAKTVAGAEAEVDPESKTRAEAKAE--AE--TK
VEAE------VRVETR--AEA-----GAAAATA--------SEAGAEAGARVEAG-----
------------------------------------------------------------
-------------------------------------------------------AGAEA
GMGFWPWNGGDDTTKGSRLGAEAEAGAGGG---------------------------AEA
GAETENSMGFWFWNGD--AAT------KG------SKLGTEAEAE--TGIGTGTGTG--T
GTGTGTGTGTGVGAGVEVQAV-----ADTSMGFWFWDGA--GAT--KGSRLGTEA-----
--EAGVGTGAQAGA--E----------AVAGTS-MEFWSWDGDEATKGSRLGAEAEPG--
------------------------A--------------------------------G--
------------------------------------------------------------
---------------V-----------------------------VAEPGAETSMGFWFW
NEDS------------------------TTKGSGLGTEVGAGL-----------------
---GSWTFSTNVNDGEDEE-EEELSRESSP-GI-EEIS----------------------
-LRTLFGAESEDSNDLRST--------NEKD--VNAESGTGDKADDTKDQFDA-------
-ANGVDIRSWFYTGNENKCED-ESSSQVKVKKSTE-S----------RGIYPSM-VPGAG
MGVW----DGTIVCSESK--LL------------HK----TSFPGED----G-----FR-
RQ-V-----------------------------------ST------------GVKVHSC
NCRCKR------TVNLDPHDLEKLICMIEMTEDPSVHEIATNALYNSADYPYPQ------
----------EIDRNIGGISVIQSLLSNPYPNV------RQ-KALNALNNI-SVAAENHR
TVKTYLSQVCEDTVTYPLNSNVQVAGLRLIKHLTITSEYQHMVTNYISEF-LRLLALGSG
E-TK-DHVLGMLVNFSKNPSMTRDLLIAN---APTALINIFSKKETK----------ENI
LNALLLFENINRHFKKRGKTYPQ--------DR-FSK--TSLY-FLFQRPKACAKKLRAL
AADCSDPEVKERVEVLINKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
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---------------------------------MGYARKVGWVTAG----------LVIG
AGACYCIYRLT--RGRKQNKEK-MA----EGGSGDVD--DAG----------------DC
---------------------------------------------------------SGA
--RYNDWSDDD-------------------------------------------------
DDS----------------N--------E-------------------------------
------------------------------------------------------------
-SKSIVWYPPWAR-----------------------------------------------
------------------------------------IG----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------T--------------------------------
-----------EAGTRARARA---------------------------------------
------------------------------------------------------------
-------------RARAT---------------------------RA----RRAVQKRAS
PNSDD--------TVLSPQELQKVLCLVEMSEKPYILEAALIALGNNAAYAFNR------
----------DIIRDLGGLPIVAKILNTRDPIV------KE-KALIVLNNL-SVNAENQR
RLKVYMNQVCDDTVTSRLNSSVQLAGLRLLTNMTVTNEYQHILANSISDF-FRLFSAGNE
E-TK-LQVLKLLLNLAENPAMTRELLRAQ---VPSSLGSLFNKKEYK----------EVI
LKLLIIFENINDNFKWEENEPA---------QNHFSE--GSLFF-FLKEFQVCADKVLGI
E-SRHDFQVRVKVGKFVAKLTERMFPKSQE------------------------------
-------------------------------------------

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---------------------------------MSRVRDAGCVAAG----------IVIG
AGAWYCVYKYT--RGRDQ-KKRRPT----KPKNRA--VAGTAARDRAGLRAGFTIDLGPG
FSPPTTVCAGD-------ETSAFDMAGAKAFVPAS------SSTEAKNETEMT-------
------------------SAVAQPLGVAGAS------------KTLEDSTMAGVPKAAVA
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------PNMAE
A-----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------PR---A--T------VEVVLPPGTAVSTSSTAATETVEVP
GMAAPTEMAEGSRMTKL------------------------------AEATEAPVSTT-P
AGVAI-----------TARAS-----------------E-FP------------------
----------------------GTSGSTR-------------------------------
-----------TA-----AVAKKAAPGAHTGAIPKVGS--VTRA---MPKGGA-------
-----------KGGTRSQTGG-K----G--KN------------KKSKAEVDELGMGFRP
GD---------GAAAAAAASAN------------GGHAFLAEVPDS-----EDGESGWTD
TESDSDSEPETQRRGRG----------------------------KK----TVAMQKRPF
PYEID--------EILGVRDLRKVLALLQKSDDPFIQQVALLTLSNNANYSCNQ------
----------ETIRKLGGLPIIANMINKTDPHI------KE-KALMAMNNL-SENYENQG
RLQIYMNKVMDDIMASNLNSAVQVVGLKFLTNMTITNDYQHLLVNSIANF-FRLLSQGGG
K-IK-VEILKILSNFAENPDMLKTLLSTQ---VPSSFSSLYNSYVES----------EIL
INALTLFEIIYDNLRAEVYN-----------YREFNK--GSLFY-LCTTSGVCVKKIRAL
A-NHHDLLVKVKVIKLVNKF----------------------------------------
-------------------------------------------

------------------------------------------------------------
--------------------------------------------MGRTQEVGWVTAGLVI
WAGTCYYIYKFTKGRAQSVRTLARNGSTV-KMETVVG----VQSQTLAKSEAE----IKT
KPQAEIGAETGTRGGPGAEVETKGTAIARHRANSQ----AKTMVEAEAETQSE-------
SKVVAGTLVMTEAVTLTEVK--AKAREVAMKEAVTQTDAEAGKIVKKEAVTQTK-AKAWA
LIAKTEAKREAMTQTKAETHILAEKETEINRVMVTQSETLAVPKE----VVKMGATNKTG
IVDETKTRALEETVSVAKTQSEAWPGATVDARGNPNGMSREVAGVDVKSCAQSQAVTKIK
GDDMPGAGIEDMGNCK---------------------------TMSRAESGEDTRASAQP
QIVAKTQTEAIPGAKVDAGNNANAMCKVGAGADVRACV-QPQTVVKKQAEVTSGAG-VDG
RGNTNVISKAITGADMRAAAQPQAVASAQTEAMSDAKVKDRGNPNAMTKAGARANLRANS
QVEALPDARDKSRGNPNVIAKAGDGTDMLSCT-QPQLVASVQANTLSDGRIKVKGNVNAM
PKEGAGVDMKAQ--GMAQSQGEALPNTRGKARGKAKAKCKTGSGMDMKTCTQPQTGVKTP
AEALLDSRVDGRGNPNATSKAGTKADQRACGQPLVVANPQGEALPGAKNKVKGNPHAVLK
VGAGEGTADSAQPQAV---------------------------------------VSFQG
EALLGTKNKVKGNPNVVLKAEVGAGAMGTAQLQIETSSKGEALLDSNNTVKGNSNAVSKA
GAGTDTTGSVQPQIVANSQGEVLPGAKNKFRGNSTTVPNSGVGPYT--------------
--------------------------TDSAQPQAVANSQGEVLPGAKNKVKANLNALSKA
EAGMGAT-----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------GSVQSQAVANAHCETLPGAKNK
VRGNWNAVSKAGAGMDTRGSAQTQAVANSQGEVLPGARNKVKGNPNVVSKAGAKEDTMGS
----------RETLPGARNKVKGNPNVVSK-----AGAKEDTMGSAQPQVVANSQRETLP
GARNKAKGNSNAISKAEAGAGIMGSVQVQVVASSQGEVLPAAKNKVRGN--SNAVPKAEA
GADTVGSAQPQAVANSQSETLLGARNKVKGSTNTVPKAGTGAGTRHSAQPQIVAGSQ---
-------------------------------------GETLPGARDKAMPSSEAETTAED
EVYAKPE--AQAMPISESEGGSGTQACRKTQLNIHDYYWNGIGVEDWIAAERWIKFRFQT
MDGDWENSVSWADDENEVSIGSWSGA-SDK--AGIIRSWAVAC----DEASVKSWAGARA
ENEVGIGTWARAG-EQASGGLWAGGQPSEGTWAGD------------KASGGAWTGAENQ
ASGGSWVLAGNQAIGELWAVGQASNGSWPGGQASGVSWVGAEAIGGSWTG--------AE
NQASGGSWAGA------------------------GA----------------SG-GSWA
GT------------SDQSGGGSKPRFEDQASGEGSWAGAGDQASGG--------SSGRSW
ADTADQASGG----------GG--------------------------------------
----------SWAGTLDQSGGGSKPIFENQTTEEG-SWAGAGGQAGGGSKVGSEDQSSGR
SWANSGDQISGGFLVGVVDQANGGSWTGA----GHPASGGPKPIFEDQASGRGSWA-DAG
DQVVGDSRLGLRDQSSGDSWAGTGDQASG------------WF-------------CVCP
G---SQ-TNGGSWGGASGQDVGG----------------PGSQVSGSSWTGAGAVDQVGG
CSKPGFEDQAIGGGFWPGPGDQTGGGSRPGSEDQS--SGIGSWGVAGGQVL---------
------------------------------------GGARP--ADQSSGGSWAGTG---N
QVSGRSWIGPG--NQ-AGDCSKPEFEDQ-ACGGSSWAGAGSQASGESWAGSTPGNE----
---ATGG-----S--RM-----------------GSE-----------------------
--------------------------DQATGGSWARSEDQASGRFQV--------RFWFG
PGAEA----------KADIVSKPDEKDEATTASRSEAGEEAIICSRTEAE------NKAS
SGSWIRSEEVA--------YMGSCVGAEAEAEAEAGA------------EAGAEAE--AG
AE----------------AVA-----EAEAEAG--------AEAGARAGAEAGAGAEAEA
G-----------------------------------------------------------
------------------------------------------------------------
---------------------------------------------AEAGTGAEAEARAEA
EA----------------------------------------------------------
------------G------AG-----AEAEAGAGAE----------AEARAGAEA-----
EAEAEARAGAE--A--------------EAE-----------------------------
------------------------------------------------------------
------------------------------------------------------------
-AEAEAEAGARAEAEA-----------------------------GAGAGAEAGAGVWSW
DGDA------------------------TTVESRLGAGEEAGV-----------------
---ESWTLARD------V-GEDELSRESSP-DI-EEIS----------------------
-LRSLFWAESENSNTFRSK--------SGKD--ADFDSGAGDNT-SIEDKFEA-------
-AGGVDIGSWFCDGNENTNED-KSASKAKAKKSSE-S----------RGTYPSM-VPGAG
MGSW----DGAMIWSETK--FP------------HQ--SEASFPVED----E-----SR-
KQ-T-----------------------------------RT------------GEKPRPW
SCRCKR------EANMDPRDLEKLICMIEMTEDPSVHEIANNALYNSADYPYSH------
----------EAVRNVGGISVIESLLNNPYPSV------RQ-KALNALNNI-SVAAENHR
KVKTYLNQVCEDTVTYPLNSNVQLAGLRLIRHLTITSEYQHMVTNYISEF-LRLLTVGSG
E-TK-DHVLGMLLNFSKNPSMTKDLLIAN---APTSLINIFSKKETK----------ENI
LNALSLFENINYHFKRRAKAFTQ--------DK-FSK--NSLY-FLFQRPKACAKKLRAL
AAECNDPEVKERVELLISKL----------------------------------------
-------------------------------------------

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---------------------------------MGYARKVGWVTAG----------LVIG
AGACYCIYRLA--RGRKQSKEK-MA----EGGSADVD--DAG----------------DC
---------------------------------------------------------SGA
--RYNDCSSDD-------------------------------------------------
DDS----------------N--------E-------------------------------
------------------------------------------------------------
-SKSIVWYPPWAR-----------------------------------------------
------------------------------------IG----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------T--------------------------------
-----------EAGTRARARA---------------------------------------
------------------------------------------------------------
-------------RARAT---------------------------RA----RRAVQKRAS
PNSDD--------TVLSPQELQKVLCLVEMSEKPYILEAALIALGNNAAYAFNR------
----------DIIRDLGGLPIVAKILNTRDPIV------KE-KALIVLNNL-SVNAENQR
RLKIYMNQVCDDTLTSRLNSSVQLAGLRLLTNMTVTNEYQHILANSISDF-FRLFSAGNE
E-TK-LQVLKLLLNLAENPAMTRELLRAQ---VPPALGSLFNKKENK----------EVI
LKLVIVLENINDNFTWEENEPS---------QNHFSE--GSLFF-FLKEFQVCADKVLGM
E-SYHDFLVKVKVGKFAAKLTERMFPKSQE------------------------------
-------------------------------------------

------------------------------------------------------------
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---------------------------------MGYARKVGWVTAG----------LVIG
AGACYCIYRLT--RGRKQNKEK-MA----EGGSGDVD--DVG----------------DC
---------------------------------------------------------PGA
--RYNDWSDDD-------------------------------------------------
DDN----------------S--------E-------------------------------
------------------------------------------------------------
-NKGIVWYPPWAR-----------------------------------------------
------------------------------------IG----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------T--------------------------------
-----------EAGTRARARA---------------------------------------
------------------------------------------------------------
-------------RARAT---------------------------RA----RRAVQKRAS
PNSDD--------TILSPQELQKVLCLVEMSEKPYILEAALIALGNNAAYAFNR------
----------DIIRDLGGLPIVAKILNTRDPIV------KE-KALIVLNNL-SVNAENQR
RLKIYMNQVCDDTITSRLNSSVQLAGLRLLTNMTVTNEYQHMLANSISDF-FRLFSAGNE
E-TK-FQVLKLLLNLAENPAMTRELLRAQ-------------------------------
-------ENINDNFKWEENEST---------QNQFSE--GSLFS-FLKEFQVCADKILGL
E-SHHDILVKVKVGKFVAKLAENMFPKSQE------------------------------
-------------------------------------------

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-------MTGAEIETGSHSKSDKKPQEEV--------MG-----------GANGEGEVPL
VVRPKV--------------------------RPQAPATSGARPKTETKS-SRARLKTET
------QSMSGT------------RH---------------------------------R
MTGARPRS----------------------------EAQIMTGARPKTD------GRAVG
DAVSKT--EAKPIPGARPKDDA--------------Q--------------AWAQNEFG-
-----AEAMPQAERAPLSNAVTWPLVNSES--TYITKSKSLCMNRELVNMDNETFPGSQ-
-GQAGIPPWFGPG-EETN------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---TGSWCYPRPRAR-EETSNESGFWSADESSNMSSFWTGEEPSIRSWPREEA---NTRS
RHRAKHQ-----T--NARSRPRSKQDPYIDS-WSGSE-----------------------
-DEAGNPFCFWAGENTNELF----------------------------------------
---------------------RPRGREEANVRPKIRTKRDDY--FDSESE------DEFY
KESWFLPGEEA----------NR-----FRHRNKEESNNILKNR----------------
NQ----KDVKNGDRVKQESRF-----DEEVIIGSWFWAEHEN------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------SL
EAG------AAAICESELGAE-----EGAI------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------GGSLFWNEEKP
TLGA--------------------------------------------------------
-----------------------------------------------VARDEVRPES---
------------------------------------------------------------
------------------------------------------------------------
-EEEALFGSWFWDRDEACFDL-NPTPVYKAKSRFRDSAEEELNVSSRPKTWDEVTVEFKP
-GPC----HDFGFSSTNPFRIPEGDS-----ENAEAKAKNVELGAEG----E--EQEPVL
QRNL--REPEFPFQYDPSY--------------------RSVQEIREHLKARESADPENW
SCTCIQ-----CELKIGSAEFEELLLLMDKIRDPFIHEISKIAMGMRTASQFTR------
----------DFIRDSGVVSLIETLMNYPSSRV------RT-NFLENMIHM-APPYPNLN
MIETFICQVCEETLAHSVNSLEQLTGIRMLRHLTITTDYHTLIANYVSGF-LTLLTTGNA
R-TK-FHVLKMLLNLSNNPLVAKKLFSAK---ALSIFVGLFNIEETN----------DNI
QIVIKMFQNISNIVKSGAMSLVD---------EDFCL--EPLV-SAFHEFEELAKRLQIQ
IDNQNDPDEGQ-------------------------------------------------
-------------------------------------------

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-----------------------------------IQGKMLFAQPTGASFSFNH------
----------NINSQLARLSIVGNTVPTPSPAL------KE-KALSALGNL-NVSAESQA
QIKMDINEGCQETASRCCNSLLQQAGLNLLISMTVINN---VLAKCVSDLKFPVITGGRG
C-AE-VQLLKPWMGLSPKPVMAGEVLGAQ---TLLSFLSLLARTEST----------GIL
PDTLVSY-----------------------------------------------------
------------------------------------------------------------
-------------------------------------------

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-------MTGAEVEPGAQAKPEKKAGEMG--------MG-----------GPEREKEVPL
VVRPKV--------------------------RPQTQVTPGAKPKTESKSVPGARPKTES
------PAMAGS------------RPKS----------------------------EASA
MARARPKT----------------------------DPPKVARARPKTG------GKAVG
GARPKS--EAKATPGASPKDDA--------------L--------------AWSQTEFG-
-----AHAMSQSDGASQTNAVIWPLVSTDS--GSVTKSKGS-LDAEVVKVDTQSFSGTQ-
-GQTGLQPRFGQR-EETA------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---GGSWYYPRPRAR-EEASNESGLWSADETCAVSSLWAGEETSIRSLPREEA---NTRS
RHRAKHQ-----T--NPKSKPRSKQETYFDS-WSGSE-----------------------
-DEAGNPLCFGAGENTNNLL----------------------------------------
---------------------RSRVREETNIRSKLRTKREDC--FESESE------DEFY
KESWFLPGEET---------NSR-----FRPRDKEESNDTSKSR----------------
AQ----KGIKHNDRAEQEARY-----EEEVIIESWFWAEKEA------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------SL
EAG------AAAICDSESGAE-----EGAI------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------GGSLFWTEEKS
NLGA--------------------------------------------------------
-----------------------------------------------LAREEARPES---
------------------------------------------------------------
------------------------------------------------------------
-EEEAIFGSWFWDRDEACFDL-NPSPVYRANCRFRDAVEEEPSVSTRPQTWDEVTFQFKR
--PS----RAIGFPPITSFRIPEGSN-----EAIEANPKNL----EG----E--EEEFLF
EPDP--LETVFPFRYDPSY--------------------RSVQEIREHLKIKEGVEPEDW
FCSCIQ-----CELKIGAGEFEELLLLMDRIQDPFIQEISKIAMGMRSASQFTR------
----------DFIRDSGIVSLIETLLNYPSSRV------RT-SFLENMVHL-APPYPNLN
MIETFICQVCEETLAHGVDSLEQVTGIMMLRHLTMTTDYHTLIANYMSGF-LSLLTTGNA
R-TK-FHVLKMLLNLSENLKVAKKLFSAE---ALSVFVGLFNIEETN----------DNI
QIVIKMFQNISNIIRSGALAFID---------EDFSL--EPLI-SAFHEFEELAKQLQVQ
IDNQNDPEVGRQS-----------------------------------------------
-------------------------------------------

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-----------------------MVDSGTEARARGKAEAGLQDG--------ISGP----
------ATARVNDKTQAKAVA-----EAELKTESV----TQAKADDGAMTRTHKVTYREA
--MAVTREVSKM------------------------------------------------
------------------------------------------------------------
-----------EDTTKSRVMVETNTKPLA-ERSIVPQTKSKAMPMSGV--SAVTKSEVKV
V-----------------------------------------------------------
-------AVIEANIRSYAKSH-----DKANTGSRPDR-----------------------
--------REEA------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------SIGM-----------------------------KSSDEDEENICSWFW
TGEE------------------------SSVGSWFWPEEETSLQV---------------
-----CKPLPK---------------------I-QEKP----------------------
------------------------------------------------------------
----------------------KPAHK------------------------PTLTIKQKA
-IAW----SRA--RYIVLVPIE------------GG--EQP-LPP---------EGNWTL
VETLIET--------PLGIRPLTKIPPYHGPYYQTLTE------IKKQIRQREKYGPNPK
ACHCKS-----RGFSLEPKEFDKLVALLKLTKDPFIHEIATMIMGISPAYPFTQ------
----------DIIHDVGITVMIENLVNNANVKE------HP-RALSMVDDS-SESSEEPK
SGESYIHQVCKDIVSCPLNSPVQLAGLKLLGHLSVKFEDHYVITSYIPDF-LTLLNKGSV
K-TK-FYVLKVFSCLSKNCANTRELISAK---VLSSLVAPFNKHESK----------ANI
LNIIEIFENINFQFKTKVKLFTK--------EK-FTK--SELI-SIFQEAKQFGQKLQDL
A-EHSDPEVRDKVIRLILKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
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-----------------------------------------------MGRARE--VGWMA
AGLM----IGAGACYCVYKLTI------------GR--QDSDKLEE------EEEDEWDD
DLELDEEEQEIWFDLTPMARPWSEEGDWNEPGAPGGSEDRPSGGGKANRA--HPVKQRPF
PYEHK--------NMWSAQSYKNFSCILDLSKCPSIKGKMFLGEMKDACFPLNH------
----------ADKSYLANLSVNGNTISTVHSTV------RE-KAPGSPNNM-KASTENQG
QIKMYIDEMYRDTLSQCCNSLLHQAGLHVLISMTIINN---MLAKSVSDLQFPLISEGSK
C-AK-VQALELPMALSEKPALAGELLGAQ---MLCSVLAVSITRGSR----------QIL
QETLLP------------------------------------------------------
------------------------------------------------------------
-------------------------------------------

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------------------------------------------------------------
-----------------------MIGSGDRTRARGETEAGLKAR--------VSGS----
------ASTKVKAETQVKAVA-----EAAPKTESV----IQAKTGNGSVVRTQTVTYTEP
VAVAMTREVSKM------------------------------------------------
------------------------------------------------------------
-----------EDMIKTGVMTKTKEKPLA-EHGRVPQSKSKTMPAFKV--SAITKSEIKV
V-----------------------------------------------------------
-------DGSDKLIRSCAKAD-----DKANIGSRPES-----------------------
--------SVEASIKSR----------AE-------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------EKGDIGI-----------------------------KSGNEDEENACSWFW
AGEE------------------------PSVGSWFWPEEETPPQV---------------
-----YKPPPK---------------------I-EETP----------------------
------------------------------------------------------------
----------------------EPI--------H----------------QPPLTIKQKA
-TAW----SRG--RYIVLVPVE------------GG--ERS-SPP---------EGNWTL
VDTLIET--------PLGVRPLTKIPPYNGPYFQTLAE------IKKQIRQREKYGPNPK
ACRCKS-----RTFSLEPKEFDKLVALLKLTEDPFIHEIATMIMGISPAYPFTQ------
----------DIIHDVGITVMIEKLINNPNVKE------HP-RALNTVDYS-SESSEETK
IGELYIHQLCKDIIFYPLNSNVQLAGLKLLAQLSMKFEDHHVIANYIRDL-LSLLNKGSV
K-IK-FYVLKVFMCLSKNQANTRELISGE---VLSSLVALFNKNESK----------ANI
LNVIEIFENINFQFKKRVKLFTK--------EK-FTK--SELI-SIFQEAKWFGQKLQDL
A-EHSDLEVRDKVIRLILKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
----------------------------------------------------NH------
----------NVNSQLARLSIVGNTVPTPSPAL------KE-KALSALGNL-NVSAESQA
QIKMDINEGCQETVSRCCNSLLQQAGLNLLISMTVINN---VLAKCVSDLKFPVITGGRG
C-AE-VQLLKPWKGLSPKPVMAGEVLGAQ---TLLSFLSLLARTEST----------GIL
PDILVS------------------------------------------------------
------------------------------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
-------MTGAEIEPSAQAKPEKKAGEEVA--------V-----------GAEVDCEVPL
VVRPKV--------------------------RTQAQGTTGARPKTKTKVMAVVGPKT--
------------------------------------------------------------
------------------------------------------------E------ASAVG
RSRTKS--KAKTKPGSQFKSRG--------------N-----------------------
-----------------THNNASPVVN-NS--GLVAKTKCLPTDRELVNRDTESFHRRKT
HSQTVFQPSLVSDDDEIN------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---MGSWHSPMPTSK-QEASYNSNFRWVDKSSVSSWFWNGDEVTTRCRSSNRTKA-RTRT
RHMAKQG-----A--NTMSRCKTNQELSILS-SSGSE-----------------------
-DESIKASLFWSQENTNTWS--GPREEA--SRSRFRSKKEIFV------------ESSSG
SDHEDHMKSRFWAGEETKFRSKRRARKEANTRARHMARREACIDFMSEPI------DVIK
KESCFQPEENI---------NTF-----SRPKTKKGARARAIAK----------------
EE----TKTKARARAKQEARS-----EEDVLVGTWFWATEESSMVDRASVQSRPQIEDES
LVGSWFWTEEDASMGTGPSSNS-KPMAKEESFGGSWLAAG-EETSMKTGTESTPESVLAA
DDE-EVIIGSWFWTGEE-IN---------------------------------PVAEEET
IVGPWFWVTDENS-VESVAGVSCE-------------------------------SRPS-
-S-EEEVICPCLWTGEAVD-ETGVREQ----------ARSGIEEETIFGAWFWAENQTYV
DSG------AEASCDIMPGPE----EEEPIIGSWFWAREEACVEADINSKSSLEDEEE-T
IMSSWFGAREEVNMKYGTGASCKFMAGAQETQNRLCSWAE-EPYVYPANGETWKYRPEEE
-----EDTVSSWFWSRKYTRPDAIVG------------------------SQLSAAEDGS
I-DGTGEEAKLLAEEDTMINTWFWKEDEEAIIEATNREESRSEAEEDVIFGSWFWAGKED
GLKAEADTGEEDRLVVEEE-GIVGSWFWAKEETIRRE----------AEEEEMIVGPWLW
EEEASLEAVTGSNFEFKSETQEE----EITVGSWFWAEEEANIEAGSQALEKTGLGTEEE
TIFGSWFWA-----------EAGTCCMSKSETN-KEII----------------------
-VESQFWSEDKVIKETESVASWESKPENEKGTAIGSWFGAEDEMNKRTGSATNCESRTLA
ADDEAIVGSWFWSGDETHFES-NPKPVFRAICASRYSVEQEPDPSRRPQTWEEVTVQFKP
-GPW----GKVGFSSIIPFRFPKEA-ASLFCEMFGGKPTQAELNPEE----E--EQESKL
ESDQ--PDPEFPFQYDPSY--------------------RSVREIREHLRAKESTEAENW
SCNCRQ-----CELKIGSEEFEELLLLMDKIRDPFIHEISKIAMGMRSASQFIR------
----------DFIREAGVVALIETLLNYPSSRV------RT-RFLENMIRM-APPYPNLN
MIETYICQVCEETLTCNLDSPEQLSGIRMIRHLTTTTDYHTLVANYISGF-LSLLAIGNT
K-TK-FHVLKILLNLSENIVMTKVLLSSE---TMSEFINLFNREETH----------DNV
QVVLAIFENIGNNIKKEEE-F----------TDDFNL--APLI-SAFHEVEKFAKEMQGK
RDNQNNPQADQEN-----------------------------------------------
-------------------------------------------

------------------------------------------------------------
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-------MTRAEIEPSAQAKPEKKAGEEV--------IA-----------GAERENDVPL
VVRPKV--------------------------RTQ--ATTGARPKTETKSVPGARPKTDA
------QAMSGA------------RPKT----------------------------EAQV
MGGARPKT----------------------------EAQGMAGARPKTD------ARAVG
GARPKT--DAKAIPGTRPKDEA--------------Q--------------AWAQSEFG-
-----TEAVSQAEGVSQTNAVAWPLATAES--GSVNKSKGLSMDRELVDVDAETFPGTQ-
-GQKGIQPWFGPG-EETN------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---MGSWCYSRPRAR-EEASNESGFWSADETSTVSSFWAGEETSIRSWPREDS---NTRS
RHRAKHQ-----T--NPRSRPRSKQEAYVDS-WSGSE-----------------------
-DEAGNLFSFWAGENTSNLF----------------------------------------
---------------------RPRVREEANIRSKLRTNREDC--FESESE------DEFY
KQSWVLPGEEA---------NGR-----FRCRDKEDPNTALKPR----------------
VQ----KDV-DGDRVKQEPRF-----EEEVIIGSWFWAEKEA------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------SL
EGG------ASAICESEPGTE-----EGAI------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------GGSTYWAEEKS
SLGA--------------------------------------------------------
-----------------------------------------------VAREEAKPES---
------------------------------------------------------------
------------------------------------------------------------
-EEEAIFGSWFWDRDEACFDL-NPCPVYKVNDRFRDAA-EELNASSRPQTWEEVTVEFKP
-GLF----HGVGFRSTSPFRIPEEAS-----EILEAKPKNMELSPEG----E--EQESLL
QPNQ--PDPEFTFQYDPSY--------------------RSVREIREHLRARESAESEGW
SCSCIQ-----CELKIGSEEFEELLLLMDKIRDPFIHEISKIAMGMRSASQFTR------
----------DFIRDSGVVSLIETLLNYPSSRV------RT-SFLENMIHM-APPYPNLN
MIETFICQVCEETLAHSVDSLEQLTGIRMLRHLTMTIDYHTLIANYMSGF-LSLLTTANA
R-TK-FHVLKMLLNLSENPAVAKKLFSAK---ALSIFVGLFNIEETN----------DNI
QIVIKMFQNISNIIKSGKMSLID---------DDFSL--EPLI-SAFREFEELAKQLQAQ
IDNQNDPEVGQQS-----------------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
-------MTGAEIEPSAQAKPEKKAGEEV--------IA-----------GAERENDVPL
VVRPKV--------------------------RTQ--ATTGARPKTETKSVPGARPKTDA
------QAMSGA------------RPKT----------------------------EAQV
MGGARPKT----------------------------EAQGMAGARPKTD------ARAVG
GARPKT--DAKAIPGTRPKDEA--------------Q--------------AWAQSEFG-
-----TEAVSQAEGVSQTNAVAWPLATAES--GSVNKSKGLSMDRELVDVDAETFPGTQ-
-GQKGIQPWFGPG-EETN------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---MGSWCYSRPRAR-EEASNESGFWSADETSTVSSFWAGEETSIRSWPREDS---NTRS
RHRAKHQ-----T--NPRSRPRSKQEAYVDS-WSGSE-----------------------
-DEAGNLFAFWAGENTSNLF----------------------------------------
---------------------RPRVREEANIRSKLRTNREDC--FESESE------DEFY
KQSWVLPGEEA---------NGR-----FRCRDKEDPNTALKPR----------------
AQ----KDV-DGDRVKQEPRF-----EEEVIIGSWFWAEKEA------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------SL
EGG------ASAICESEPGTE-----EGAI------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------GGSTYWAEEKS
SLGA--------------------------------------------------------
-----------------------------------------------VAREEAKPES---
------------------------------------------------------------
------------------------------------------------------------
-EEEAIFGSWFWDRDEACFDL-NPCPVYKVSDRFRDAA-EELNASSRPQTWEEVTVEFKP
-GLF----HGVGFRSTSPFRIPEEAS-----EILEAKPKNMELSPEG----E--EQESLL
QPNQ--PDPEFTFQYDPSY--------------------RSVREIREHLRARESAESEGW
SCSCIQ-----CELKIGSEEFEELLLLMDKIRDPFIHEISKIAMGMRSASQFTR------
----------DFIRDSGVVSLIETLLNYPSSRV------RT-SFLENMIHM-APPYPNLN
MIETFICQVCEETLAHSVDSLEQLTGIRMLRHLTMTIDYHTLIANYMSGF-LSLLTTANA
R-TK-FHVLKMLLNLSENPAVAKKLFSAK---ALSIFVGLFNIEETN----------DNI
QIVIKMFQNISNIIKSGKMSLID---------DDFSL--EPLI-SAFREFEELAKQLQAQ
IDNQNDPEVGQQS-----------------------------------------------
-------------------------------------------

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------------------------------------------------------------
-----------------------MIGSTASARAAEEAEIDLKLE--------ISSP----
------DYTKVKAMTQAKTAL-----EAEPTIELV----THTKIFV-----------T--
------------------------------------------------------------
------------------------------------------------------------
----------------------------ETSSDVMPQTKSMVIPMSKANVNSETKSEIKV
D-----------------------------------------------------------
-------AGKEA------KAN-----DKADTDCISNI-----------------------
--------EEEASIQSE----------TK-------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------DTGSVVL-----------------------------RSTDEDEENVCSWFW
TGEE------------------------PSVGSWFWPKEDTPLQV---------------
-----YKPPLK---------------------I-QEEP----------------------
------------------------------------------------------------
----------------------KPTPE------------------------PVLTLKQKA
-AAW----ARA--RYVVLAPVD------------AR--KKS-TPP---------KGNWTL
VATLIET--------PLGIRPLTKIPPYDGPYYQTLAE------IKEQVKQKENYGPSPK
NCRCNP-----RGFSLEPEEFDKLVDLLKLTTDPFIHEIATMIMGVSRAYPFTQ------
----------DIIHDVGITVMIENLVNNPQVEE------HS-KALAIISEN-PEPLEEAN
IDGPYIREICKEINANSLNSQLQLTALKLLVGTSMRFENHHLIASHIPDF-LILLNKGSF
R-IK-FYALRLLYCLSKNQANVREMITGD---VLSTLVTFFNKNESK----------VNI
LNTLQILENINFHFKKRAKLFTK--------EE-FTK--SELI-SIFQEAKLLGQKLQDL
A-ENSDPEVRDKVIRLILKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
-----------------------------------------------MGRARE--VGWMA
AGLM----IGAGACYCVYKLTI------------GR--DDSDKSEE------E-EEEWDD
DQELDEEEPDLWFDFTTMARPWSEDGDWTEPGAPGGTEDRPSGGGKANRT--YPVKQRPF
PYEHK--------NTWSTQSFRNFSCILDLSRHPFIQGKMWFAQLKDAGFSFSH------
----------DINSHLASLPIVGNTILTPHPAI------KE-KALCALDNL-NASVENQG
QIKMYVNEVCRETVSHCCNSFLQQAGLNLLISMTVINN---MLAKPISDVKFPLISEGSE
C-AE-VQVLKLLIGLSEKPVLAGELLGAQ---MLLSFTSLFIRNANR----------QVL
PQTLAS------------------------------------------------------
------------------------------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------MTGAEVETGSQAKPDKKPQEEV--------AG-----------GAERESEAPL
VVRPKV--------------------------RPQAPATSGARPKTETKSSSRARPKTET
------QSVSGT------------RH---------------------------------R
MSGARPRS----------------------------EAQLMSGARPKTD------ARAVG
GARPKT--EAKPIPGARPKGDA--------------Q--------------AWAHSEFG-
-----AEAMPRAERAHLSNSVTWPPVNVGS--ATVTKSKSLSMNTELASMGSEIFSGTQ-
-GQPGIEPWFGPR-EEAN------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---MGSWCYPRPRAR-EETSNES----ADENSTMSSFWTREETSIRSWPREEV---NTRS
RHRAKHQ-----T--NARSKPRSKQDPYIDS-LSGSE-----------------------
-DEASNPFCFWAGENTNDMF----------------------------------------
---------------------RARGRDEANARPKIRTKREDY--FED--E------DEIY
KESWLLPGEEG----------NR-----FRRRDKEEPNKTLKNE----------------
NE----KDVKNDETVEQESRL-----EEEVIIGSWFWAEQET------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------NV
EAG------ASAICDAEPGAE-----EGAI------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------GGSLFWTEEKP
SLGA--------------------------------------------------------
-----------------------------------------------VARDEVRPES---
------------------------------------------------------------
------------------------------------------------------------
-EEEALFGSWFWDRDEACFDP-NPTPVYTAKSRYRDPE-EDLNLASRPKTWDEVTIEFKP
--PC----HGLGFPSPRPFIIPEGAS-----GNSEEKAKNAELGAEG----E--EQDSVA
QRDL--PEPEFPFQYDPSY--------------------RSVQEIREHLKARESAQPENW
SCTCIQ-----CELRISSAEFEELLLLMDRIRDPFIHEIAKIAMGMRTASQFTR------
----------DFIRDSGVVSLIEALMNYPSSRV------RT-NFLENMVHM-APPYPNLN
MIETFICQVCEETLSHSVNSPEQLTGMRMLRHLTITTDYHVLIANYVSGF-LALLTTGDA
R-TK-FHVLKMLLNLSDNPMVAKKLFSAK---ALSIFVGLFNIEETN----------DNI
QIVIKMFQNISNIVKSGAMSLLD---------DDFSL--EPLV-SAFHEFEELAKQLQIQ
IDNQNDPEEGQ-------------------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------MGRARE--VGWMA
AGLM----IGAGACYCVYKLTS------------GR--EESDELED------EEEDQWDD
DEDLDEEEIEIWFDFTAMARPWSKDGDWDEPGAPGGTEDRPSGGGKANRA--HPIKQRPF
PYEHK--------NTWCAQSFKTFSCALDISKCPSIQRKLLFADSTNAGFPLSH------
----------NVNRHLAGFSMVGNRIPISQPTV------RD-KALRVPENP-NASVENQG
QIKMYTDEVCRETVLRCYNSFLQQAGLNLLIRMTVINN---MLAKPISDLKFPLLSDGSG
C-AK-VQVGEPLMRLPEKPVWAGELLSVQ---TLLSFMSLFLRSGNR----------ELL
MEALSP------------------------------------------------------
------------------------------------------------------------
-------------------------------------------

------------------------------------------------------------
--------------------------------------------MGRVIDVGWATAGLVI
WAGTCYCIYRLTKGRAQSVSRFARNGSRI-ETESVAG----VQNQTLATVKAMAGAETET
RAT--TEPGTGEGGEPVAEVDTEIPILVSPDTNCQ----AMTMLEEEIETHSG-------
TSSLVEAMVMTEAMTFTEAT--VQAKEVTMKEAVTQTDAEPEEVGKKEAVTQTK-ANTWA
KSDRAEVKKEAMTQTKAEACTVTEKETEINRVTVTQSEVLAVTKE----VVKIGTVNETG
IVAEATIRSLEEPVSVTRTDSEARLDATIDNDGHPHDMPLIVAGVDVKSFAQPQTVAIIQ
NDDMMVGEADDKGNLQ---------------------------ATSKAGCGVDTKASSQP
HVVSSILAESSPGARA--CNNPDGICEAE--ADVRACIIQPETVATIQAEATPGAV-IDG
GEDASVVFKTMTGADITD-TDPPAVTSDQTKVMPDAKVKGKGNTNATAKSGAKANTKNNL
QT---------------------------------------DGDDLPDDKTKAKDNANTI
PKEGAQT--------VAQNQGEALPNTKGKARGKAKAKCKAGAATDVKTCAQPQAGTKTQ
GETSSDSKVDSKSDSNAVSKAGAKADQKACGQPQPVVTCQNEALPGTKNKAKGNQNLTPK
AEPGTATAGSAQT-----------------------------------------------
------------------------------------------------------------
-------------NVTSSQGETAPGAKNKVKGNRNSVPKAGAGPDT--------------
--------------------------MGSSQSQTAANSHSEALPGAKNKVKSNPNVVPKA
EAGAGACPQSV-------------------------------------------------
------------------------------------------------------------
--------------------------AISQGSALTGTKTKVKGNSSAVSKPDAGAGT---
------------------------------------------------------------
---------------------------------------------------------AGS
VQAKAVANSQGETLPGSKSKAKGNSNAVPKTE-----AGATTTDSVQPQ------AEALL
GARNKGKGNSNSVPKADSGASTILA-----LASSQAEALLGARNKVRVN--SNMVPKAEA
GLGARGSAQSQVVVRSQNEPLLSARNKMRSNA--STKSGAKTGTRSSAQPQAVVRTQNAA
LLGARGKG----------------------------------------VSSLQVAAPVDN
KIYARPV--TGAVPTAEMVSVV------AAQPNMHDYYWNGIGVEDWIAAERWIKFRFET
IDGDWEN--LWTEEENAASVGPWTGA-NDK--SGVVSSWAVAC----DETSIKSWTGARP
ENELALGSWVSAG-DQASGGLWAGAQANEGVWVGD------------KVSGGSWTGVENQ
ISAGSWVVSGNQAIAGPWAVSQVTDGSWPAVQASGVSWILDQATG-TWTV--------AD
NQAAGVSWAGA--------------------------GNIVSIGYWTGAVDQTNA-VAWT
GT------------VDQTGGEAKPRFEDQASEKATWAGAVAQ------------------
--------PTSRLGTVDPSGGTVWSSTGGQAGGVSTSGVADQS-SGSWAGARNQ------
----------SWTGTGDQSDGGSKPGFENQTGDGG-SWTGTIGQATGGSKSVPEDQSAGR
SWANSGDQLSGGFLANAQSQP------GS----GELTAGG-----VDQSSAGGCWA-GSG
DQSGAESRMGSRDQSNVESWPGPGDQTGG------------WY-----------------
--------------------------LQVNPSSSGSWLGTGTQVSGVSWTGD----QIGG
CSKPGYEDQAMGGGFWTGAGEQTTAGSRPAVSED-QSSGGVSWGGAGGHVV---------
------------------------------------------------------------
---GGSWT-------------KSGFEDQ-ACGGSSWPGAGNQTSGESWPGSRSSNE----
---ASGG-----------------------------------------------------
--------------------------------SRLDTQDQASGRFLVSAEVEANEGFWFG
PGSEAFIGDST----------------------TSGTREESIISSGLTDE------KKPS
TESWTRSEETA--------LTGACVGGEAATVTGAEAATVTGAEADVDTEA---------
------------------------------KVG--------TEAGAETEPVAEMGVETRT
EAG--------------------------------------------------A------
--------------------------------AAVAAPEP--------------------
------------------------------------------------ETGAEAAPRVEA
GAGSEAGMGFWSWDGDAATKGSRLGAEA--------------------------------
--------EAGVGGGAETEAG-----TENSMGFWLGA-----------------------
--EAEAGVGAGTEAVSE----------AVTETS-MEFWSWDGDAASKGSRLGTETEAG--
------------------------A--------------------------------G--
VVAET---------------------------------------GAETRMGFWFWNEDST
TK--GSKLATEAGAEV-----------------------------VAEGGTETRMELWAW
DGDA------------------------ASKGTRLGTEVEAGL-----------------
---GSWTFSTNINDDD-D-EEEELSRESSP-GI-EEIS----------------------
-LRNLFGADNEDSNDLRST--------NEND--ANSESGTGDKA-ST-------------
-ADGVDIRSWFCTGNENRCDGDESTSQVKAKRSAD-S----------SDIYPSM-VPGAG
MGVW----DGTLVCSASK--LL------------HQ----SSFPGED----G-----FR-
K--A-----------------------------------GA------------GDREHSC
NCRCRR------DANLDPEDLERLICMVEMTEDPSVHEIATNALYNSADYPYPQ------
----------EIDRNMGGISVIQSLLSNPHPTV------RQ-KALNALNNI-SVAAENHR
TVKTYLSQVCEDTVTYPLNSNVQVAGLRLIRHLTITSEYQHMVTNYISEF-LRLLAMGSG
E-TK-DHVLGMLVNFSKNPSMTKDLLIAN---APTALINIFSKKETK----------ENI
LNALLLFENINRHFKKRAKTYPQ--------DR-FSK--SSLY-FLFQRPKACAKKLRAL
AADCSDPEVKERVEVLINKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MGGPRGAGWVAAG----------LLLR
AGACCCIYRLT--RGRRR-DDG---------ELGMRP--SK-------------------
------------------------------------------SAE---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------DLT
DGSYD--------NVLNAAQLQKLLYLLESTEDPVIIERALITLGNNAAFSVNQ------
----------AIIRELGGIPIVGNKINHSNQSI------KE-KALNALNNL-SVNVENQI
KIKIYINQVCEDVFSGPLNSAVQLAGLRLLTNMTVTNDHQHMLHSYITDL-FQVLLTGNG
N-TK-VQVLKLLLNLSENPAMTEGLLHAQ---VDSSFLSLYDSHVAK----------EIL
--------NINNCLKTEGHLAV---------QPTFTE--GSLFFLLHGE--ECAQKIKAL
V-NHHDAEVKEKILTIIPKI----------------------------------------
-------------------------------------------

------------------------------------------------------------
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-----------------------------------------------------E---DLT
NGSYD--------DVLNAEQLQKLLYLLESTEDPVIIERALVTLGNSAAFSANQ------
----------VIIRELGGIPIVGSKINSPNHSI------KE-KALNALNNL-SVNVENQI
KIKIYINQVCEDVFSGPLNSAVQLAGLRLLTNMTVTNDHQHLLSSYITDL-FHVLLTGHG
P-TK-VQVLKLLLNLSENPAMTEGLLGAQ---VDSSFLSLYDGHVAK----------EIL
LRVLTLFQNINNCLQKEGRLAV---------QPPFTK--GSLFFLLYGE--ECAQKMRAL
L-YHPDAEVKEKVTI-IPES----------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
---------------------------------MSRARDAGFIAAG----------IVIG
ASAWYCVYKYT--RGRDQ-KKRRPA----KSKNRA--SVGTGTRARAGLRSGFTIDLGPG
FNPPTPASVEAMNK-SQEEASTLTTSAAGEMVPAA------PSPKTRNGAESKVQEANGA
--GTKPTTMESAVPTSAASAVTHTPKMAQVP------------TAAEATKIVVAPKVAEA
PRS----------------I--------EAAGAIAP-LGPAVPLGVVQAPGPAIPS----
-----------------PSIASTM--------------SAAI------------------
---------PWAVA----------------------------------------SPGVAQ
SPGPA----------APTMAV---QSLVPAAPSWAVVAP---------------------
-----------------PGAVYIPVAAHF-----------TGAAAAT----RVTQSPGTV
VPPLPPPSLGAAMLSRAVQSPLATVPPRAVQSPGATVHXXXAQSPGVVVPSRAVQYSGAT
VPTMTGAPSGTSVPPRGPTTP---------------------RAPASTQRASTTEVMQVP
GVAAPTNATQTPRVTTP------------------------------AMVAGASLP----
----M-----------ISGAA-----------------E-TP------------------
----------------------GTSGSSK-------------------------------
-----------KAA-----TGKKATPGAHTGAIPKAGS--ATGA---VPKGG--------
-------G---KGGNRNRNGG-K----GKNR-------------K-NKVEVDELGMGFRP
GD---------GAAAAAAASAN------------GGQAFLAEIPES-----EEGESGWTD
TESDSDSEPEVQQRGKG----------------------------KR----TIPMHKRPF
PYEID--------EILGARDLRKVLALLQKSDDPFIQQVALLTLSNNANYSCNQ------
----------ETIRKLGGLPIIANMINKTDPHI------KE-KALMAMNNL-SENYENQG
RLQVYMNKVMDDIMASNLNSAVQVVGLKFLTNMTITNDYQHLLVNSIANF-FRLLSQGGG
K-IK-VEILKILANFAENPDMLKKLLGTQ---VPSSFSSLYNSYVES----------EIL
INALTLFEIIFDNLRAEVFN-----------YREFNK--GSLFY-LCTTSGVCVKKIRAL
A-NHHDLLVKVKVIKLVNKF----------------------------------------
-------------------------------------------

------------------------------------------------------------
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-------MTGAEIEPSAQAKPEKKAGEEV--------IA-----------GAERENDVPL
VVRPKV--------------------------RTQ--ATTGARPKTETKSVPGARPKTDA
------QAMSGA------------RPKT----------------------------EAQV
MGGARPKT----------------------------EAQGMAGARPKTD------ARAVG
GARPKT--DAKAIPGTRPKDEA--------------Q--------------AWAQSEFG-
-----TEAVSQAEGVSQTNAVAWPLATAES--GSVNKSKGLSMDRELVDVDAETFPGTQ-
-GQKGIQPWFGPG-EE-T------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---MGSWCYSRPRAR-EEASNESGFWSADETSTVSSFWAGEETSIRSWPREDS---NTRS
RHRAKHQ-----T--NPRSRPRSKQEAYVDS-WSGSE-----------------------
-DEAGNLFSFWAGENTSNLF----------------------------------------
---------------------RPRVREEANIRSKLRTNREDC--FESESE------DEFY
KQSWVLPGEEA---------NGR-----FRCRDKEDPNTALKPR----------------
AQ----KDV-DGDRVKQEPRF-----EEEVIIGSWFWAEKEA------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------SL
EGG------ASAICESEPGTE-----EGAI------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------GGSTYWAEEKS
SLGA--------------------------------------------------------
-----------------------------------------------VAREEAKPES---
------------------------------------------------------------
------------------------------------------------------------
-EEEAIFGSWFWDRDEACFDL-NPCPVYKVSDRFRDAA-EELNASSRPQTWEEVTVEFKP
-GLF----HGVGFRSTSPFRIPEEAS-----EILEAKPKNMELSPEG----E--EQESLL
QPNQ--PDPEFTFQYDPSY--------------------RSVREIREHLRARESAESEGW
SCSCIQ-----CELKIGSEEFEELLLLMDKIRDPFIHEISKIAMGMRSASQFTR------
----------DFIRDSGVVSLIETLLNYPSSRV------RT-SFLENMIHM-APPYPNLN
MIETFICQVCEETLAHSVDSLEQLTGIRMLRHLTMTIDYHTLIANYMSGF-LSLLSTANA
R-TK-FHVLKMLLNLSENPAVAKKLFSAK---ALSIFVGLFNIEETN----------DNI
QIVIKMFQNISNIIKSGKMSLID---------DDFSL--EPLI-SAFREFEELAKQLQAQ
IDNQNDPEVGQQS-----------------------------------------------
-------------------------------------------

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---------------------------------MGSARTAGWVAAG----------LIVG
VGAGFYLYRLS--RGRQR-T----------------------------------------
------------------------------------------------------------
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-------------------KRG------------VRPSG---------------------
--------------SA-------------------------------------E---DLT
NGSYN--------DVLNAEQLRKLLYLLESTEDPIITEKALVTLGNSAAFSTNQ------
----------AIIRELGGIPIIGSKINSPNHSI------KE-KALNALNNL-SVNVENQI
KIKVFVSRVCEDVLSSPPDSAAQLAGLRLLTNMTVTNAHQHLLSTAVADL-FGLLLAANG
N-TK-VQVLKLLVNLSENPAMTEGLLSAQ---VDASFLSLFDGHVAQ----------EIL
LRVLTLFQNINNCLRVE---AV---------QPPFPE--GSLFSLLYGE--ECVQKMKAL
V-NHHEVDVREKAVTIIPKF----------------------------------------
-------------------------------------------

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---------------------------------MGYARKVGWVTAG----------LVIG
AGACYCIYRLT--RGRKQSKEK-MA----EGGSGDTD--DAG----------------DC
---------------------------------------------------------SGA
--RYNDWSDDD-------------------------------------------------
DDN----------------N--------E-------------------------------
------------------------------------------------------------
-SKSIVWYPPWAR-----------------------------------------------
------------------------------------IG----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------T--------------------------------
-----------EAGTRARARA---------------------------------------
------------------------------------------------------------
-------------RARAN---------------------------RA----RRAVQKRAS
PNSDD--------TVLSPQELQKVLCLVEMSEKPYILEAALIALGNNAAYAFNR------
----------DIIRDLGGLPIVAKILNTRDPIV------KE-KALIVLNNL-SVNTENQR
RLKIYMNQVCDDTITSRLNSSVQLAGLRLLTNMTVTNEYQHILANSISDF-FRLFSAGNE
E-TK-LQVLKLILNLAENPAMTRELLRAQ---VPSSLGSLFNKKENK----------EVI
LKLLIIFENINDNFKWEENEPT---------QNQFGK--GSLFV-FLKEFQVCADKVLGI
E-SHHDFLVKVKVGKFMAKLAEHMFPKNQE------------------------------
-------------------------------------------

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------------------------------------------------------------
-----------------------MIGSGAGARAGEEAGSALQAG--------ISGP----
------SKARVKVKTQAEAMA-----EAELKTPSV----AQDKSEDGMMARTQTVTYTEA
--VALTRDISKM------------------------------------------------
------------------------------------------------------------
-----------EDTTETRLIAETKANPLA-EPSIVPQTKSKVMPVSRV--SAITKSEVKV
G-----------------------------------------------------------
-------AGSKKNIRSCATPD-----DKACIKPSQDI-----------------------
--------NKE-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------ASIGL-----------------------------KPSDQDEENVCSWFW
NEEE------------------------PSLGSWFWPEEDTLPKV---------------
-----YEPPPK---------------------V-QEKL----------------------
------------------------------------------------------------
----------------------KPT--PI----------------------PTCTTKQKA
-TAW----LRA--RYSVLVPVE------------GG--EQS-LPP---------EGNWTL
FETLIET--------PLGIRPLTRIPPYGGPYLQTLAE------IKNQIRHREKYGPNPR
TCRCKS-----RSFSLEPKEFDKLVALLKLTKDPFIHEIATMIMGISPAYPFTQ------
----------DIIHDVGITVMIEDLVHNPSVKE------HP-RTLNKVDDS-SESSEEPK
LGESNIQQVCKDIISYPLNSPMQLAGLKLLAQLSVKFEDHHMIVNYIPDF-LTLLRKGSV
K-TK-FYVLKVFLCLSKNQANIRELISAK---VLSSLVAPFNKKESK----------ANI
LNIIEIFENINYQLKKKTKLFTK--------DK-FTK--SELI-SIFQEAKEFSQKLQDL
A-EHSDPEVRDKVIRLVLKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
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---------------------------------MSRARDAGCVAAG----------IVIG
ASAWYCVYKYT--RGKEQ-KKKRLA----KPKNRA--SVGTGTRARAGLRAGFTIDLGPG
FNPPTPVSVETMNK-AEE-ASSLATAVAEEVAPTA------PSPKVQNGAERKVQELKSG
--T--EANMESIVMTSAACAVTPPPKVTGPL------------TAAEAPEIVGGPKVVET
SST----------------T--------EASAAVAS-LGPAVSPRVAQSPGPAAPS----
-----------------PSIVSPG--------------PTAI------------------
---------PWAVA----------------------------------------HPGTVQ
SPGSA----------ATAMAV---QSLVPASPSWAVVAP---------------------
-----------------PGAVYIPVAAHF-----------TGPAAAP----RITQSPGTV
IPPLPPPSSV-------LPRGVPTVPTRTVQSPGAAVHPVAAQSPGVV-PPRTVQYSGAT
VPSGA------------PATP---------------------RAAASTQRAATT---EVP
RAAAPAEATGTPGTGTP------------------------------AVVAEASLP----
----M-----------HSGAA-----------------E-TP------------------
----------------------GTSGSSK-------------------------------
-----------TAA-----TGKKAAPGVHTGAIPKTGA--ATGA---VPKGG--------
-------G---KGGNKNRSGG-K----GKNR-------------K-NKVEVDELGMGFRP
GD---------GAAAAAAASAN------------GGQAFLAEIPES-----EEGESGWTD
TESDSDSEPEVQQRGKG----------------------------KR----TIPMHKRPF
PYEID--------EILGVRDLRKVLALLQKSDDPFIQQVALLTLSNNANYSCNQ------
----------ETIRKLGGLPIIANMINKTDPHI------KE-KALMAMNNL-SENYENQG
RLQVYMNKVMDDVMASNLNSAVQVVGLKFLTNMTITNDYQHLLVNSIANF-FRLLSQGGG
K-IK-VEILKILSNFAENPDMLKKLLGTQ---VPSSFSSLYNSYVES----------EIL
INALTLFEIIFDNLRAEVFN-----------YREFNK--GSLFY-LCTTSGVCVKKIRAL
A-NHHDLLVKVKVIKLVNKF----------------------------------------
-------------------------------------------

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------------------------------------------------------------
-----------------------MINSSAREKAREEIGDGLKAE--------ISGP----
------DNAGVRDEAKAMAVV-----EAEPKSELV----TQVKFGDGTMAMTQTMTYTEP
--VTGTKEVNKM------------------------------------------------
------------------------------------------------------------
-----------ENMTDNRVMDQTKTKVLL-ELGIVPQTKSEASSMSRL--SAITKSTVRV
V-----------------------------------------------------------
-------SGSEASFRSCSKAD-----DRANIVSRYET-----------------------
--------KEETSIKSM----------AR-------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------NKVGIGI-----------------------------KSTDEEEENICSWFW
IGEE------------------------PK---------EISLQI---------------
-----YKSPPK---------------------I-QERP----------------------
------------------------------------------------------------
----------------------KPTHK------------------------SKLTIKQKA
-TAW----SRA--RYIVLVPIE------------GE--EQP-LPP---------EGNWTL
VTTLIET--------PLGIRPLTKIPPYNGLYFQTLAE------IKTQIRQREKYGPNPR
AGLCKS-----HCFSLEPKEFDKLVALL------------------NPSYPFTQ------
----------DVIHDVGIIDMIENLINNPNDHE------DS-GDFDVVDSS-SESSEEGK
MGESYIYTICKNIMYCSLNSPVQLAGIKLLVHLSVKFKNHHLIVSYIPDF-LTLLNNGNV
K-TK-FCILKVFLCLSKNQANVRELISAE---VLSSLVALFDKSESK----------GLI
LSILEIFENINFQFKKRAKLFTK--------EH-FTK--SELI-SIFQEAKGVGQKLHSL
A-EHSDYEVRDKVIQLRLKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
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---------------------------------MGGPRGAGWVAAG----------LLLG
AGACYCIYRLT--RGRRR-GDR---------ELGIRS--SK-------------------
------------------------------------------SA----------------
------------------------------------------------------------
-------------------------------GA-LE---EG-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------TS-------------------------------
------------------EGQ-L----CGRS--------------AR---------P-QT
GG---------------TWESQ------------WSKTSQ--------------------
-----------PE--------------------------------------------DLT
DGSYD--------DVLNAEQLQKLLYLLESAEDPVIIERALITLGNNAAFSVNQ------
----------AIIRELGGIPIVANKINHSNQSI------KE-KALNALNNL-SVNVENQI
KIKIYISQVCEDVFSGPLNSAVQLAGLRLLTNMTVTNDHQHMLHSYITDL-FQVLLTGNG
N-TK-VQVLKLLLNLSENPAMTEGLLRAQ---VDSSFLSLYDSHVAK----------EIL
LRVLTLFQNIKNCLKIEGHLAA---------QPTFTE--GSLFFLLHGE--ECAQKIRAL
V-DHHDAEVKEKVVTVIPKI----------------------------------------
-------------------------------------------

------------------------------------------------------------
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--------------DTDLGHI--ENQSQDCIELYNWASTMAGVKN--RMRVKTKTENR-A
GVQAE--AKRETTGV------VRSV---------------------AKTQAKAIAKAGTQ
-----EDPV---------------------------------------------------
------AEVKAA-------------SKNKIVTEMKEGALADFSPKAEDEATR---GFVPE
AS---AES----------------------------SAES-----RSTCKDKTGIDTWFW
AEEE------------------------ASVGSWFWNGEEAGN-RFSA------------
---------KDEGK-------ADICPPSCA----K-------------------------
------------NLEPVAGANCKARPGAEE------------------------------
EEEENVIGSWFWDGDETSFDP-NPRPVSRIIKPQP---VDEINEKDRPKDWSEVTIWPKA
PAVTP---AVLGFRSQVPFEKKPPS----YVVLASAEENTHSLPVA-----T--ACPSRS
TPSSSQPVSEYPFGSDPCI--------------------QTIEEIRRQIRIREVNGIKPF
ACPCKM------ECYMDSEEFEKLVTLLKSTTDPLIHKIAQIAMGIINVHPFAQ------
----------EFINEVGVVTLIESLLSFPSSEM-------RKKAVITL-NP-PSGDERQR
KVELHVKHMCKETMSFPLNSPGQQSGLKILGQLATDSNHHHIVANYFSEL-FHLLSLGNR
K-TR-NLVLKVLLNMSENPTAARDMINIK---ALAALKLIFNQKEAK----------ANL
VSAVAIFINIKEHIRKGSIVVVD----------HLSY--NTLM-AIFREVKVIIETM---
------------------------------------------------------------
-------------------------------------------

------------------------------------------------------------
--------------------------------------------MGRVQDVGWATAGLVI
WAGTCYCIYRLTKGRSQSVSRFSRNGSRI-EMDTVVG----EENQTMATGEAMAGAETET
RN----------------------------------------------------------
-SLLVETMVMTDAETFTEAT--AQAKEVTMKEAVTQTDVEAEEVGKKEAVTQTK-SKAWA
MADRAEVKKEAMTQTKAEAPTLAEKETEINRVTVTQSEVLAVTKE----VVKIGTMNETG
IVAEAMMPALEQTVCVTRTQSETRLDVTIDTSENPNDMPLIVAGVDVKSYAQSQAVTIIQ
NDDVIDDEADDQGNLK---------------------------NTSKAGSAVDRDTSAHP
HAVANILTEAKPGAKDDACDNISDICEAE--ADMRTCIIQPETVATTQAEARSGAT-TDD
GEDASDVFKTVTGADITDTD-P---------------QAGKGNASGTAKAGAKANTKT--
-----------------------------NFV-DPEPVANVQGDDLPDGKIKAKDNANTI
SKEGTQT--------VAQSQGEALPNTKGKARGKAKAKCKAGAATDVKTCAQPQGGIKSQ
AEALSDSKVDSKSDSNAVSKAGAKADQKACAQPQSVVNCQNEALPATKTKVKGNSNPMPK
AETGTATAGSAQT-----------------------------------------------
------------------------------------------------------------
------------TVVTSSQGETTPGAKNKVKGNRNSVPKAGAGPDT--------------
----------------------------------TANSHSEALPGAKNKVKSNPNIVPKA
EAGVGASPQPV-------------------------------------------------
------------------------------------------------------------
--------------------------AVSQGTALTGTKTKVKGNSNAVSKPDAGAGTT--
------------------------------------------------------------
------------------------------------------------------------
--------GSGETFPGSKSKVKGNSSSVPKAE-----SGASTI-----LALASSQAEALL
GARNKVRGNSNTVPKAESGSGARGSAQS--------------------------------
----------QAVVSSQNDTLLGARNKIRANA--STKSGAKTGTRGSAQSQAVVSSQNEA
LLGARDKG----------------------------------------LSSSQVGATADN
KTYARPV--AGAVPASEVVSAA------GAQPNMHDYYWNGIGVEDWIAAERWIKFRFQT
IDGDWENSVSWAEDESGASVGPWSGA-SDK--PGMVSSWAVAC----DESSIKSWTGARP
ENEVALGSWVSAG-DQASGGLWAGAQAS----------------------DGTWTGAENQ
ISAGSWVVSGNQAIAGPWAVSQVTDGTWPAVQASGVSWVVDQATG-TWTV--------AD
NQAGAMSWAGA--------------------------GNIVSIGYWTGAVDQTNA-VAWT
GT------------ADQTVGEVKPRFEDQASEKGTWAGAAVQTSGESRLGPEDQSGGRAW
AETADQASAASRLGTVDPSAGASWPGTGAQVVGVSTSGSADQASSGSWAATRNL------
------AGERSWTGTGQQSDGGSKAGFENQTGNEG-TWTGTVSQASGGPKSVPEDQSAGR
SWTDSGDQLSGGYLVGPLNQANGESQPGS----GNLAASG-----VNQSSGGGCWP-GSG
DQSGGESRMGPREQSNAESWPGPGDQTGG------------WY-------------CTYT
P---SQDIGGASWGVASVQDVGGSKPVQVNQSSSGPWLGTGTQVGGVSWTGD----QVGG
CPKPGFEDQAIGGGFWAGAGDQSTGGSRPAVSEG-QSSGGVSWGGAGAHVI---------
------------------------------------GGSR---TDQASGGSWTAIG---S
QVSGGSWVGSV--DQ-TSGCSKSGFEEQ-ARGGSSWPGAVDQTGGESWPGSRASNE----
---ASGG-----------------------------------------------------
--------------------------------SKLDTQEQASGRFLVSAEVEANEGFWFG
PGSEAFIGSWCWTEE-ATVLPIADMKDEASVESTSGTREETSTSSGLGDE------KKTS
TESWTGAEETA--------FAGTCVGGEPESVAGAEAGAEAGAEAKAEAEV--EAE----
----------------VEAKV-----EAEVEAE--------V------------------
----------------------------------------------EAEVEAKV------
EAE---------------------------------------------------------
----------------------VEA-------------KVEAEVEAEVEAKAEAEVELGA
EAGA--------------------------------------------------------
------ETGAGTGSGAEAEAV-----TETSMGFWFWDGDGAA----KGSRLGT-------
--ESEAGGGAGAEAVTE----------TVAETS-LELWSWDGDAATKGSRLGAEAEAG--
------------------------A--------------------------------G--
VVAEA---------------------------------------GAETRVGFWIWNEDST
TK--GSGLGAEAGAGV-----------------------------VAEGGAAARMELWSW
DGDA------------------------ASKGSRLGAETEAGL-----------------
---GSWTFSTDVNDD--D-DEEELSRESSP-GI-EEIS----------------------
-LRNLFGAESEDNNDLRST--------NEKD--ANSESGTGDKD-STKDKFDA-------
-ADGVDIRSWFCTGNENRCED-ESTSQVKVKKSTE-P----------RGIYPSM-VPGAG
MGVW----DGTIICSESK--LL------------HQ----TSFPGED----G-----FR-
RQ-V-----------------------------------NT------------GDKVHSC
NCRCKR------DVNLDPQDLEKLICMIEMTEDPSVHEIATNALYNSADYPYPQ------
----------EIDRNIGGISVIQSLLSNPHPTV------RQ-KALNALNNI-SVAAENHR
KVKTYLSQVCEDTVTYPLNSNVQVAGLRLIRHLTITSEYQHMVTNYISEF-LRLLAMGSG
E-TK-DHVLGMLVNFSKNPSMTKDLLIAN---APTALINIFSKKETK----------ENI
LNALLLFENINHHFKKRAKTYPQ--------DR-FSK--SSLY-FLFQRPKACAKKLRAL
AADCSDPEVKERVEVLINKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
--------------------------------------------MGRTRDAGCVAAGVVI
GAGACYCVYRLTWGRDENEKIWDDDEESSDGAETGVETERSAQANPGPVTTAR----VET
DPVVK--AEVGSGVKSGSDLKVE--AYSGPQSGGGLEAKAKALFKVLKEQASAKMGRGGR
MSIISGNRTLASSLPCSGGR--GGGCHPTRSKAGGKASGKSGKLKSKSAS----------
----------------AAACPXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XIMNLVIDFTEPGLRDLGSVPSELISLFNKEQDR------------------------ET
LLNVLTIFENI---------------------------------------------NDNI
KSEGFASSK------------KEFSRNSLFFLFKESGVCV--------KKIKALANHTDL
VVKVKV--LKV----LTK-----L------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-------------------------------------------

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----------------------MP-----PSRDQELTWAKVLKALTVVLRPPL---GTNS
IAQLAAVRLTQA---RRRRR---K-FPQIRAGLSSFW--------ALCNCSYSGKKQT--
-ALDPRRPCL---------------------------------SLSRTCKPKL--KSLTR
TSRHPLT---LSNPVPRPGSV-NN-----PSCTMSRVRDAGCVAAG----------IVIG
AGAWYCVYKYT--RGRDQ-TKKRMA----KPKNRA--VAGTGARARAGLRAGFTIDLGSG
FSPPTPVRAEAEDR-AQDEASALDTVGAEAVAPAA------SSPEAQSGAGSQAQEADGA
--GVGPKA-ESVVGAAMSSAIAPPPGVTEAL------------GAAEAPAMAGAPKVAEA
PRE----------------A--------ETSRAA-VPPGTVVPTEA-AA-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------PAEVTEGPR------------VAAPT---------
---------KVA---EAP------------------------------------G-----
-VASPTEAAEAPVPATP------------------------------TG-----AA----
---AP-----------T-GAA-----------------E-SP------------------
----------------------GTSGSPR-------------------------------
-----------TAVVPGTSAAKKATPGAHTGAIPKATS--ATGA---VPKGGG-------
-----------KGVTRSRNGG-K----GKGK-------------K-SKVEVDELGMGFRP
GD---------GAAAAAAASAN------------GGQAFLAEVPDS-----EEGESGWTD
TESDSDSEPETQRRGRG----------------------------RR----PVAMQKRPF
PYEID--------EILGVRDLRKVLALLQKSDDPFIQQVALLTLSNNANYSCNQ------
----------ETIRKLGGLPIIANMINKTDPHI------KE-KALMAMNNL-SENYENQG
RLQVYMNKVMDDIMASNLNSAVQVVGLKFLTNMTITNDYQHLLVNSIANF-FRLLSQGGG
K-IK-VEILKILSNFAENPDMLKKLLSTQ---VPASFSSLYNSYVES----------EIL
INALTLFEIIYDNLRAEVFN-----------YREFNK--GSLFY-LCTTSGVCVKKIRAL
A-NHHDLLVKVKVIKLVNKF----------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
---------------------------------------MTGTKN--KTRAQSA------
-IQAKATEERKATGV------VRPV---------------------AKTWAKAKDKPGSP
-----TDAV---------------------------------------------------
------AEMKAV-------------SKNKVVAEMKEGALSETKALGKTI-----------
-----GDF----------------------------SPKAGNESSSSTCENGA-----G-
--------------------------------------VDAGN-HSSA------------
---------KNDKP--------EIGAQVSA----E-------------------------
------------ELEPVAGACCKPRSGVEE------------------------------
EEEENVIGNWFWEGDGTSFDP-NPKPVSRIVRPQP---PEDCF---------EVIIWPKS
PA-------VTPAVF-RL-DPSPPS----YVVLGLAEEISYSWPVA-------TACPSRN
TCSCSQPVPE------------------------------------------EVNGIKPF
ACPCKM------ECYVDPEEFEKLVSLLKSTTDPLVHKRAQIAMVITLNPP---------
-----------------------------------------------------SGDERQH
KIELHVKHMCKDTTSFPLNSPGQQSELKILGQLTMDFVHHYIVASDFSEL-CHLPSSGKY
K-AR-NPVLKVILNMPENPTAARDTINMK---ALAASKLIFNRKEAK----------TNL
VSGVAVFINIKEHIRKGSIVVVD----------HLSY--NTLM-GIFREVKGIIETM---
------------------------------------------------------------
-------------------------------------------

------------------------------------------------------------
--------------------------------------------MGRTQEVGWVTAGLVI
WAGTCYYIYKFTKGRAQSVRTLARNGSTV-KMETVVG----VQSQTLAISEAE----IKT
KPQAETGAETGTRGGPGAEVETKATAIARHRANSQ----AKTMVEAEAETQSE-------
SKVVAGTLVMTEAVTLTEVK--AKAREVAMKEAVTQTDAEAGKIVKKEAVTQTK-AKAWA
LVAKTEAKREAMTQTKAETHILAEKETEINRVMVTQSETLAVPSE----VVKMGATNKTG
IVDETKTRALEETVSVAKTQSEARPGATVDARGNPNGMSREVAGVDMKSCAQSQAVTKIK
GDDMPGAGIEDMGNCK---------------------------TMSRAESGADMRASAQP
QIVAKTQTEAIPAAKVDAGSNTNAMCKVGAGADVRACV-QPQTVVKKQDEVTSCAR-VDG
RGNTNVISKAITGADMRAAAQPQAVASAHAEAMSDAKVKDRGNPNAMTKAGARANLRANS
QVETLPDARDKSRGNPNVIAKVGDGTDMLSCT-QPQLVASVQANALSDGRIKVKGNVNTM
PKEGAGVDMKAQ--GMAQSQGEALPNTRGKARGKAKAKCKTGSGMDMKTCTQPQTGVKTP
AEALLDSRVDGRGNPNATSKAGTKADQRACGQPLVVANPQGEALLGAKNKVKGNPHAVLK
VGAGEGTADSAQPQAV---------------------------------------VSFQG
EALLGTKNKVKGNPNVVLKAEVGAGAMGTAQLQIEASSKGEALLDSKNKVKGNSNAVSKA
RAGTDTTGSVQPQIVANSQGEVLPGAKNKVRGNSTTVPNSGVGPYT--------------
--------------------------TDSAQPQAVANSQGEVLPGAKNKVKANLNALSKA
EAGMGAT-----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------GSVQSQAVANAHCETLPGAKNK
VKGNWNAVSKAGAGMDTRGSAQTQAVANSQGEVLPGARNKVKGNPNVVSKAGAREDTMGS
AQPQVVANSQRETLPGARNKVKGNSNVVSK-----AGAREDTMGSAQPQVVANSQRETLP
GARNKAKGNSNAISKAEAGAGIMGSVQVQVVASSQGEVLPGAKNKVRGN--SNAVPKAEA
GADTVGSAQPQAVANSQSETLLGARNKVKGSTNTVPKAGTGAGTRHSAQPQIVAGSQ---
-------------------------------------GETLPGARDKAMPSSEAETTAED
EVYAKPE--AEAMPISESEGGSGTQACRKTQPNIHDYYWNGIGVEDWIAAERWIKFRFQT
MDGDWENSVSWADDENEASIGSWSGV-SDK--AGIIRSWAVAC----DEASVKSWAGARA
ENEVGIGTWARAG-EQASGGLWAGGQTSEGTWAGD------------KASGGAWTGAENQ
ASGGSWVLAGSQAIGELWAAGQASNGSWPGGQASGVSWVGEEAIGGSWTG--------AE
NQASGGSWAGA------------------------GAGNMSSVSYWAGVVDQASG-GSWA
GT------------SDQSGGGSKPRFEDQASGEGSWAGAGDQASGGSRLGPEDQSSGRSW
ADTADQASGGSRLGHVDQSSGG--------------------------------------
----------SWAGTLDQSGGGSKPRFENQTTEEG-SWAGAGGQAGGGSKVGSEDQSSGR
SWANSGDQISGGFLVGVVDQANGGSWTGA----GHPASGGPKPIFEDQASGRGSWA-DAG
DQVVGDSRLGLRDQSSGDSWAGTGDQASG------------WF-------------CVCP
G---SQ-TNGGSWGGASGQDVGGSRPGPTNQSSAGSWDSPGSQVSGSSWTGAGAVDQVGG
CSKPGFEDQAIGGGFWPGAGDQTGGGSRPGSEDQS--SGIGSWGVAGGQVL---------
------------------------------------GGARP--ADQSSGGPWAGTG---N
QVSGRSWIGPG--NQ-AGDCSKPEFEDQ-ACGGGSWAGAGSQASGESWAGSTPGNE----
---AIGG-----S--RM-----------------GSE-----------------------
--------------------------DQATGGSWARSEDQASGRFQVSVEVEANEGFWFG
PGAEAVIGSWCWTEAKADIVSKPDDNNEATTTSRSEAGELAIICSRTEAE------NKAS
SGSWIRSEEVA--------YMGSCVGAEAGAGA--------------E--AGAEAE--AG
AE----------------AMA-----E---------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---AEAEAGAEAGAGA---------------------------------GAEAGAGVWSW
DGDA------------------------TTVESRLGAGEEAGV-----------------
---ESWTLARD------V-GEDELSRESSP-DI-EEIS----------------------
-LRSLFWAESENSNTFRSK--------SGKD--VNFDSGAGDNT-SIKDKFEA-------
-AGGVDIGSWFCDGNENTNED-KSASKAKAKKSSE-S----------RGTYLSM-VPGAG
MGSW----DGAMIWSETK--FP------------HQ--SEASFPVED----E-----SR-
KQ-T-----------------------------------RT------------GEKPRPW
SCRCKR------EANMDPRDLEKLICMIEMTEDPSVHEIANNALYNSADYPYSH------
----------EAVRNVGGISVIESLLNNPYPSV------RQ-KALNALNNI-SVAAENHR
KVKTYLNQVCEDTVTYPLNSNVQLAGLRLIRHLTITSEYQHMVTNYISEF-LRLLTVGSG
E-TK-DHVLGMLLNFSKNPSMTKDLLIAN---APTSLINIFSKKETK----------ENI
LNALSLFENINYHFKRRAKAFTQ--------DK-FSK--NSLY-FLFQRPKACAKKLRAL
AAECNDPEVKERVELLISKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
--------------------------------------------MGRVQDVGWATAGLVI
WAGTCYCIYRLTKGRYQSVS---RDGSRI-KTETV----------------------TET
RAM--TEPETGEGGEPVAEVDTKVPVLTH----------------------SE-------
TSLLVETMVMTDAVTFTEAT--GQAKEVTMKEAVTQTDVETEEVGKKEAVTQTK-SKAWA
V-----VKKEAMTQTKAEAPSLAEKETEINRVTVTQSEVLAVTK-------------ETG
IVAEATIRALEETVCVTRTQSETRLDVTVDTNENSNDMPLIVAGVDVKSYAQPQAVTIIQ
NDDMIGDEGDDQGNLK---------------------------NTSKAGSAVDKDTSAQP
HIVANILAEAMPGAKDDACDNTNDICEAE--ADLRTYIIQPETVATIQAEAMSGAT-TDD
GEDASDVFKAMTGAEITD-TNPQAVTSDHIEATPDANAKGKGNASATAKAGAKANTKTNL
QTDALPETEDKNRSDTNDMAKAEASVDVVSCA-QPDPVA--------------SDNANTI
SKEGTQT--------TAQSQGEALPNTKGKARGKAKAKCKAGAAADVKPCAQPQGGIKTQ
AEPLSDSKVDSKSDSNAVSKAGAKADQKACAQPQPVVNCQNEALPATKNKVKGNPNPMPK
AEAGTATAGSAQT-----------------------------------------------
------------------------------------------------------------
------------NVVTSSQGETTPGAKTKVKGNRNSVPKAGAGPDT--------------
--------------------------TGSAQNQTVASSHSEALPGAKNKVKSNPNVVPKA
EAGVGACPQSV-------------------------------------------------
------------------------------------------------------------
--------------------------AVSQGTALTGTKAKVKGNSNAVSKPDAGAGTM--
------------------------------------------------------------
----------------------------------------------------------GS
AK--AVTSSQGETLPGSKSKVKGNSNAVPKAD-----AGATTTDSVQPQ------AEALL
GARNKVRGNSNSVPKAESGASTILA-----LASSQAEALLGARNKVRGN--SNTVPKAEA
GSGARGSAQSQAVVSSQNETLLGARNKIRANA--STKSGAKTGTRGSAQPQAVVSSQSEA
LLGARDKG----------------------------------------LSSSQVEATADN
KTHARPV--AGGGAPSESVSGA--------------------------------GFRFQT
IYRDWENSVTWAEDENGAAVGPWSGA-NDK--TGIVTLWA--------------------
-----------------------------------------------GTGGASWTGAENQ
LSAGSWVVSGNQAITGPWAVSQVSDGSWPAGAASGVSWVVDQATG-TWTV--------AD
NQAGAMSWAGA--------------------------GNIVSIGYWTGAVDQTNA-VAWT
GT------------AEQVGGEVKPRYEDQASEKGTWAGAAVQTSGDSRLGPEAQSSGRAW
AETADQASAASRLATVDPSSGVSWPVTGAQAGGVSTSGSADQSSSGSWTGTRNL------
------TGERSWTGTGDQSNGGAKPGFENQTGAEG-SWTGTISQASGGSKSVPGDQ----
SWTNSGDQLSGGFLVGPLDQASGNSQP------------------VNPSSGGGCWA-GSG
DQSGGESRMGTRGQTNGQSWPGTGDQTGG------------WY-------------S---
-----------SWG-ATAQDIGVSKPVQVNQSSSGAWLGSGTQVGGVSWTGD----QVGG
CPKPGFEDQAIGGGFWAAAGDQSTGGSRPAVSED-QSSGGVSWGGAGAHVI---------
------------------------------------GGNRTCPTDQASGASWAGIG---S
QVSGGSWVGPV--DQ-TSGCSKSGFEDQ-TCGGGSWAGAVDQTSGESWPGSRASNE----
---ASGG-----S--KL-----------------DTQ-----------------------
--------------------------E------------QTSGRFLVSAEVEANEGFWFG
PGSEAFIGSWCWTEE-ATILPITALA----------------------------------
---------------------G------------TCAEVETEAKDTAEAEAGAGPE--AG
AGP-------------------------E------------AGAGPEAGAGPEAG-----
------------------------------------------------------------
-------------------------------------------------------AGPEA
GAGTE-------DGAGPEAGAEAEAGAEAE---------------------------AEV
EAEVEAEVEAEVEAEVEAEAEAEAEVEAE------AEAEAEAEAE--AE-----------
-----------------AEAE-----TENSMGFWVWDGD--AAT--KGSRLGAEA-----
--EAEVEAGAGGGAEAE----------AETENS-MGFWFWDGDATTKGSKLGAEAGAE--
------------------------A--------------------------------G--
IGTGA-------------------------------------------------------
--------------GA-----------------------------EAEAVTETSMGFWFW
EGDG------------------------AAKGSKLGAEPEAGVGAGAEAVA----ETVAV
PSMEFWSWDGDAATKG-----SRLGAEVEA-GA-GVVAEAGAETRMGFWFWNEDSTTKGS
GLGAEAGAGVVAEGGAEAR--------MDPD--TNSESGTGDK-DSTKDKFDA-------
-ADGVDIRSWFCTGNENRCED-ESTSQVKAKKSTE-P----------RGIYPPM-VPGAG
MGVW----DGTIVCSESK--LL------------HQ----TSFPGEE-------------
---------------------------------------------------------VPC
HCRCRR------EVNLDPQDLEKLICMIEMTEDPSVHEIATNALYNSADYPYPQ------
----------EIDRNIGGISVIQSLLSNPHPTV------RQ-KALNALNNI-SVAAENHR
KVKTYLSQVCEDTVTYPLNSNVQVAGLRLIRHLTITSEYQHMVTNYISEF-LRLLAMGSG
E-TK-DHVLGMLVNFSKNPSMTKDLLIAN---APTALINIFSKKETK----------ENI
LNALLLFENINHHFKKRAKTYPQ--------DR-FSK--SSLY-FLFQRPKACAKKLRAL
AADCSDPEVKERVEVLINKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
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---------------------------------MGGARDAGWVAAG----------LVLG
AGACYCIYRLT--RGPRP-GGR-----------KLRP--SR-------------------
------------------------------------------SAE---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------DLT
DGSYD--------EVLNAKQLEKLLYLLELTDDPIIVEKALVTLGNNAAFSANQ------
----------AIIRELGGIPIIGNKINSLNHSI------KE-KALNALNNL-SVNVENQV
KIKVYVQRVCEDVFADPLNSAVQLAGLRLLTNMTVTNDYQHLLSSYITGL-LHLSLIGNG
S-TK-VQVLKLLLNLSENPAMTEGLLSAQ---VDSSFLSFFDGHIAN----------EIL
LRALTLFQNINNCLRVEGCPAG---------QPPFAK--GSLFSLLYGE--DCAQKMRAL
A-HHHDVDVKEKVLAIMPKV----------------------------------------
-------------------------------------------

------------------------------------------------------------
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-------MTGAEIEPSAQAKPEKKAGEEV--------IA-----------GPERENDVPL
VVRPKV--------------------------RTQ--ATTGARPKTETKSVPAARPKTEA
------QAMSGA------------RPKT----------------------------EVQV
MGGARPKT----------------------------EAQGIAGARPKTD------ARAVG
GARSKT--DAKAIPGARPKDEA--------------Q--------------AWAQSEFG-
-----TETVSQAEGVSQTNAVAWPLATAES--GSVTKSKGLSTDRELVNVDAETFPGTQ-
-GQKGIQPWFGPG-EETN------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---MGSWCYSRPRAR-EEASNESGFWSADETSTASSFWAGEETSVRSWPREES---NTRS
RHRAKHQ-----T--NPRSRPRSKQEAYVDS-WSGSE-----------------------
-DEAGNPFSFWGGENTNNLF----------------------------------------
---------------------RPRVREEANIRSKLRTNREDC--FESESE------DEFY
KQSWVLPGEEA---------NSR-----FRHRDKEDPNTALKLR----------------
AQ----KDV-DSDRVKQEPRF-----EEEVIIGSWFWAEKEA------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------SL
EGG------ASAICDSEPGTE-----EGAI------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------GGSAYWAEEKS
SLGA--------------------------------------------------------
-----------------------------------------------VAREEAKPES---
------------------------------------------------------------
------------------------------------------------------------
-EEEAIFGSWFWDRDEACFDL-NPCPVYKVSDRFRDAA-EELNASSRPQTWDEVTVEFKP
-GLF----HGVGFRSTSPFRIPEEAS-----EMLEAKPKDLELSPEG----E--EQESLL
QPDQ--PSPEFTFQYDPSY--------------------RSVREIREHLRARESAESESW
SCSCIQ-----CELKIGSEEFEELLLLMDKIRDPFIHEISKIAMGMRSASQFTR------
----------DFIRDSGVVSLIETLLNYPSSRV------RT-SFLENMIHM-APPYPNLN
MIETFICQVCEETLAHSVDSLEQLTGIRMLRHLTMTIDYHTLIANYMSGF-LSLLTTANA
R-TK-FHVLKMLLNLSENPAVAKKLFSAK---ALSIFVGLFNIEETN----------DNI
QIVIKMFQNISNIIKSGKMSLID---------DDFSL--EPLI-SAFREFEELAKQLQAQ
IDNQNDPEVGQQS-----------------------------------------------
-------------------------------------------

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-------------------------------------------------------MGFRP
GD---------GAAAAAAASAN------------GGQAFLAEIPES-----EEGESGWTD
TESDSDSEPEVQQRGKG----------------------------KR----TIPMHKRPF
PYEID--------EILGARDLRKVLALLQKSDDPFIQQVALLTLSNNANYSCNQ------
----------ETIRKLGGLPIIANMINKTDPHI------KE-KALMAMNNL-SENYENQG
RLQVYMNKVMDDIMASNLNSAVQVVGLKFLTNMTITNDYQHLLVNSIANF-FRLLSQGGG
K-IK-VEILKILANFAENPDMLKKLLGTQ---VPSSFSSLYNSYVES----------EIL
INALTLFEIIFDNLRAEVFN-----------YREFNK--GSLFY-LCTTSGVCVKKIRAL
A-NHHDLLVKVKVIKLVNKF----------------------------------------
-------------------------------------------

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---------------------------------MGGARDAGWVAAG----------LLLG
AGACYCIYRLT--RGQRR-GGR---------GLRLRP--SR-------------------
------------------------------------------SAV---------------
------------------------------------------------------------
---------------------------------TLA---ER-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------TP-------------------------------
------------------EGQ-F----CLDS--------------AH---------T-QK
GG---------------TLKSP------------WSKML---------------------
--------------EI-------------------------------------E---DLT
NGSCD--------DVVNAEQLQKLLYLVESTEDPVIIERALVTLGNNAAFSANQ------
----------VIIRELGGIPIVGSKINDPNHSI------KE-KALNALNNL-SVNVENQI
KIKIYMNQVCEDVFSGPLNSPMQLAGLRLLTNMTVTNDHQHMLNGYITDL-FQVLLTGNG
S-TK-VQVLKLLLNLSENPAMTEGLLGAQ---VDSSFLSLYDGHMAK----------EIL
LRVLTLFQNINNCLKKEGHLAV---------QPTFTK--GSLFFLLYGE--ECAQKMRAL
V-NHHDADVKEKVTI-IPKF----------------------------------------
-------------------------------------------

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---------------------------------MGYARKVGWVTAG----------LVIG
AGACYCIYKLT--RGRKQNKEK-MA----EGGSGDVD--DAG----------------DC
---------------------------------------------------------SGA
--RYNDWSDDD-------------------------------------------------
DDS----------------N--------E-------------------------------
------------------------------------------------------------
-SKSIVWYPPWAR-----------------------------------------------
------------------------------------IG----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------T--------------------------------
-----------EAGTRARARA---------------------------------------
------------------------------------------------------------
-------------RARAT---------------------------RA----RRAVQKRAS
PNSDD--------TILSPQELQKVLCLVEMSEKPYILEAALIALGNNAAYAFNR------
----------DIIRDLGGLPIVAKILNTRDPIV------KE-KALIVLNNL-SVNAENQR
RLKVYMNQVCDDTITSRLNSSVQLAGLRLLTNMTVTNEYQHMLANSISDF-FRLFSAGNE
E-TK-LQVLKLLLNLAENPAMTRELLRAQ---VPSSLGSLFNKKENK----------EVI
LKLLVIFENINDNFKWEENEPT---------QNQCGE--GSLFF-FLKEFQVCADKVLGI
E-SHHDFLVKVKVGKFMAKLAEHMFPKSQE------------------------------
-------------------------------------------

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---------------------------------------MTGTKS--KAK----TE-KRA
KVPAKTGAEKEVTRV------VKAV---------------------AKTWSKTKAKAGHK
-----ADVV---------------------------------------------------
------TEMKVV-------------SKNRVATEMKK--------WLKVI-----------
-----ADV----------------------------SCKAENEVTRSMCKDKAGIKTWFW
AGEE------------------------ANISCWFWKGEEAGN-HSST------------
---------KDKSK-------ADTGAQVCA----E-------------------------
------------KLESVAVASCKSVSGVDE------------------------------
EEEENVIRNWFWEDG-TNFDP---------------------------------------
------------------------------------------------------------
---DSQSIPESLFGSDPCI--------------------KTIDEIRQQIKIREVNGIKPF
ACSCKM------ECYLDSEEFEKLV-----------------------------------
----------KFINEVGVVILIESLLTFPSPER-------RKK-----------------
------THMCKSTVSFPLNSPGQQTALKILGQLTTESVHHYIVPSYFSGL-FHLLFQGNH
K-TR-HFVLKVLLNVSENPTAARDLINMK---ALAVIKLIFNQKEAK----------PNL
VSAVAIFINIKEHIRKGSIVVID----------HLSY--NTLM-AIFHEIKEIIETM---
------------------------------------------------------------
-------------------------------------------

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-------MTGAEIETGVQAKPEKKPGKEVA--------G-----------GAERENEVPV
VVRPKV--------------------------RTQAQVMLGARPQTETMAVTETHP----
------------------------------------------------------------
------------------------------------------------------------
----KS--EAKATTVEMSMNET--------------Y--------------SWAKTEFD-
-----AEVLLKTEGVSQNNAIAWPLISTES--GSVAKPKTSSMVSELASMDAESFPGTKV
KSQSGIQHLLVSE-EETS------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---MGSWCHPRPTSK-KETFHNCDFTWVDRSFMNSWFCSREEVSTRLHPRDRVKA-STRS
RHMAKEE---------AMSRPQTSWELYVAS-SSGSE-----------------------
-DESIKKSWFWIREKTSIQS--RPREET-NSSSWFGSKKEVS-------------ESSSG
SECEDNVKSWFWAGE--EGRYKPRARKGANVSARHRAKQETSIDFMSESM------DVVK
KEPWFLSREKT---------SNL-----AKPKSKKEVRARAVVK----------------
EE----AKIKARARAKPEARP-----EEEFLTGAWFWAVGDCSIVGGATVKSGSQVEDEP
IVGSWFWTEEE------TSGTF-RPQTEQEPIGSSVLGTG-EKTNVETEADATSKSVPTD
DKE-KVIASFC-WANEE-TS---------------------------------PEAEEET
ILGSWFWVSDAAS-VEAGLGANCG-------------------------------SRPK-
-SEGEEVIGPWFGAGEEIGTVAEFREE----------ARTGA--ETIFWPWFWAGNQAHM
DSG------AEVNCDTMPGT--E--EEEPIIGSWFWPGVEACGRAEVNNKSSLEDKEK-S
ITSPWFGTTEEIRMKYAAGAQCQFMTAAEEINSESGFWSGEGPCMFPTNEGSWKSRPEDE
-----QDTVNSWFCSIRYTGPETVVG------------------------PSLWAVEESS
TDDRAEGEAKPPTKEETMITSWFWKGD-EAIIEAADKEESRLDIEEEDIIGSWFWAREED
RLKTEVEAGEEDRLAAEEE-LFDGSWFWARF-WA-EE-----------------------
----ETSLEAGASFESKHGAEKE----EIIVGSWFWAEE-ESIDIRPQAVEETTSRSGEE
TIFESWFWDAKE-----VNVEAKTCCASKPEND-KEMI----------------------
-LESRSLSGEKDINETEAGATSESRPENEEGAVVGSWFMAKKEDNNRTSDGTNCETRTIA
EEDEAIVGSWFWTRDETHFES-DPSPVYRAICRSSCSVEQEPDASHRPQSWEEVIVQFKL
-GPW----GMLVFPSPNPFRFSKEA-AFLFSEMFGGKPKHIELSLEG----E--DQESLL
QSNQ--PDPELPFRYDPFY--------------------WSVVQIREHLRTRESTEPESC
SCSCIQ-----CELKIGPEEYEEELLLMDKIQDPFIHKISKIAMGMRTTSQYTH------
----------DFIRNSGVVSLIETLLNYPSSRV------RT-RFLENMIYM-APPYPNRN
ITQTYVCQVCEETLAYSLDSPEQLSGVKMVRYLTRATDYHTLVARYISGF-LLLLATGNT
E-TR-FHVLKMLLNLSENPVMTKELLNAE---AVSEFMGLFSRKEAN----------DNI
QVFLAMLDNIGNNIKKRVL-FT----------NNFSL--EPLT-SAFHEVEKFAKELQGK
IDHKKDP-----------------------------------------------------
-------------------------------------------

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-----------------------MIGSTTKAKAREESGASLKPG--------SKSL----
------ANAKEKAKSQTKKVV-----ATE-LKELG----SQAEARDEAMARTQTVTRTEP
--ETVTWKVKKK------------------------------------------------
------------------------------------------------------------
-----------KDRTNTGVKDHTKIELWA-EPALVPHTKADDLPMSVV--ITVTKSEIRV
D-----------------------------------------------------------
-------TGIEASVKYSSKAS-----DTGSMKHIPEK-----------------------
--------KKETLVRSG----------T--------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------GDKASIVI-----------------------------NTTDEDEEYVCSWFW
TGEE------------------------PSVGSWFWPKEETPLQV---------------
-----YQPPPK---------------------V-EKEP----------------------
------------------------------------------------------------
----------------------EP-TD-----------------------KFDFTLKRKA
-AAW----ARG--RFIVLVPVE------------EC--EQS-LPP---------EGNWTL
VATLIET--------PLGIRPLTKIPPFEGPYFQTLAE------IKNQIREREKYGPNPK
ACRCKS-----RTFSLEPIEFDKLVALLKLTRDPFIHQIATMIMGISPAYPFTQ------
----------DIVHDVGITVMIENFVNNPNAEK------YC-RTLNVS-AS-ADTSEEAK
DNEAHVDKVCRDILSCPLNCSVQVEELKLLASLSMKFEYHHVIINYVRYF-ITMLSKGSV
K-IK-FQILRVILYLSKNQANTRELISAE---VLSSLIALFHKNESK----------ANI
LHIINIFENINFQFKKRAKLFTK--------EM-FTK--SELI-SIFQEAKQFDQKLQDL
A-DHSDPDVRDKVIRLILKL----------------------------------------
-------------------------------------------

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------------------------------------------------------------
------------------------------------------------------------
---------------------------------MSRVRDAGCVAAG----------IVIG
ASAWYCVYKYA--RGRNHMMKKRLA----KPKTRA--VAETGARARAGLRAGFTIDLGPG
FSPPTPVRTGAEER-AQDESSALDTAGAEAVVPAA------SRAETQSGAGNKAQETEGA
--RLGPKAES---VATVASAVAPPLWEAKAP------------SAAKPPAMVGAPKSAEA
PGV----------------A--------EAPRAPVVPHVVPVPTEASPPTEAV-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------EASI------------PAMPT---------
------------------------------------------------------------
------------------------------------------------GAAATLGV----
---AA-----------PSGTA-----------------E-AP------------------
----------------------GPSGSSR-------------------------------
-----------TAA-----AAKKATPGAHTGAIPKAGS--ATGA---VLKGGA-------
-----------KGVTRSRTGG-K----GKGK-------------K-NKVEVDELGLGFRP
GD---------GAAAAAAASAN------------GGQAFLAEVPDS-----EEGESGWTD
TESESDSEPETQQKGKG----------------------------RR----SVPMQKRPF
PYEID--------EILGVRDLRKVLALLQKSDDPFIQQVALLTLSNNANYSCNQ------
----------DTIRKLGGLPIIANMINKTDPHI------KE-KALMAMNNL-SENYENQG
RLQIYMNKVMDDIMASNLNSAVQVVGLKFLTNMTITNDYQHLLVNSIANF-FRLLSQGGG
K-IK-VEILKILSNFAENPDMLKKLLSTQ---VPSSFSSLYNSYVES----------EIL
INALTLFEIIYDNLRAEVFN-----------YREFNK--GSLFY-LCTASGVCVKKIRAL
A-DHHDLLVKVKVIKLVDKF----------------------------------------
-------------------------------------------

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-----------------------------SIGPWFWNGEKVGH-QFSA------------
---------KNEDE-------TDTGPTINA----EEL-----------------------
------------GIELVIGASCKPRPGAEE------------------------------
EKEEKVIGNWFWDGDDTSFDP-NPKPVYRIIKPQV---VCETDEENKLKEWCEGTAWHNN
SADIS---AFLAFASQALQRMRHVS----YNSPSSGKKNTGSLSLM--------TSLSEG
TSICLESIDAYPLESETCT--------------------QTIEKIREQIRIRELSGIKQC
GYPCKT------ECCLGSERFEKLFSLVKSDTDPLIHKIAQISMGIINIHLLAP------
----------PLINEMAVLKFIESLLGFQFSDL-------TGKSEITL-NH-ISAEEKQH
MINSHVLCVFMDTVTWPLNLPGQRSRLKELEQLTTDFDHHYIISTYLAEL-GQVLAQGNS
K-TR-NLVLKIILNMSENPETARDMIDFD---YLSVLKLIFSQTEAK----------ANL
VTAVAIFVNIKEHIRKGWITIIY----------PQYY--DELK-AMFHDVKMITEKLS--
------------------------------------------------------------
-------------------------------------------

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---------------------------------------MTRTKS--KARGQAKTEKR-A
KVPVKAGTEKEVTGV------VKAV---------------------AKTRSKTKAKAECK
-----ADEV---------------------------------------------------
------TEMKVV-------------SKNKVAAEMKERVLSEPKAPVKAI-----------
-----ADV----------------------------SSKAENKVTRSTGKDKAAIDTWFW
AGEE------------------------ASISSWFWKGEEAGN-HSST------------
---------KDKNK-------ADTGAQVCA----E-------------------------
------------KLESVAGASCKSVSGVDD------------------------------
DEEENVIGNWFWEGDDTSFDP-EPKPVYRIVRPQA---VDLINQTNRPKDWSEVTIWPNA
PAVTP---AVLGFRSQIPSETRSSS----YVVVSSTEESTHSA--------AAAACPSRN
ACSSSQSIPEFPFGSEPCI--------------------QTIDEIRQQIKIREMNGIKPF
ACPCKM------ECYLDSEEFEKLVSILKSTTDPLIHKIAQIAMGIHNVHPFAQ------
----------EFINEVGVVTLIESLLTFPSPER-------RKKAVITL-NP-LSGDERQQ
KIELHVKHMCKETVSFPLNSPGQQTGLKILGQLTTESVHHYIVASYFSEL-FHLLSEGNR
K-TR-NLVLKVLLNMSENPTAARDLVNMK---ALAALKLIFNQKEAK----------ANL
VSAVAIFVNIKEHIRKGSIVVVD----------HLSY--NTLM-AIFREVKEIIETM---
------------------------------------------------------------
-------------------------------------------

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-------MTGAEIESGAQVKPEKKPGEEVV--------G-----------GAEIENDVPL
VVRPKV--------------------------RIQAQIMPGARPKDKSKVIPGASTKV--
------------------------------------------------------------
------------------------------------------------E------TSAVG
GARPKS--KAKAIPVSRFKEEA--------------Q--------------MWAQPRFG-
-----PERLSKTERNSQTNIIASPLVSTDS--VLVAKTKYLSEDRELVNTDTESFPERKA
HYQAGFQPFFRSK-EETN------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---MGSWCCPRPTSK-QEVSPNSDFKWVDKSSVSSLFWSGDEVTAKFHPGNRVKD-SARS
RHMANQE-----A--NTMSRSQTNQELYISS-SSGSE-----------------------
-DESVKTPWFWARDKTNTWS--GPREDP-NSRSRFRAKKEVYV------------ESSSG
SEHEDHLESWFGAGEEAKFRCKMRAGKETNNRARHRAKREACIDFMPGSI------DVIK
RESCFWPEENA---------NTF-----SRPMIKKEARARAMAK----------------
EE----AKTKARARAKQEARS-----EEEALIGTWFWATDESSMADEASIESSLQVEDES
IIGSWFWTEEEASMGTGASSKS-RPRTDGEPIGDSLFGTG-EKTSMKTGAEATSECILAA
DDE-QVIIGSWFWAGEE-VN---------------------------------QEAEEET
IFGSWFWVTDAAS-VESGFGVSCE-------------------------------SRSR-
-SEEEEVIGPWFWSGEQVDIEAGIGEE----------ARPGAEEETIFGSWFWAENHTYM
DCR------AEASCGTMQGAE----EEGPIIGSWFWTRVEACVEADVNSKSSLEDKEE-A
MI-PCFGAKGKVSMKHGTDVRCRFMAGAEETNNRSCFWAEKEPCMYPTCGGIWKTRPEEE
-----EDIVNSWFWSRKYTKPEAIIG------------------------SWLWATEESN
I-DGTGEEAKLLTEEETMINSWFWKD--EAISEATDREESRPEAEEGDIIGSWFWAGEED
RLEPAAEVREEDRLVAEKE-GIVGSWFGAREETIRREAGSCSKSSPKAEEEEVIIGSWFW
EEEASLEAVAGVGFESKPGTEKE----EITVGSWFWPEEETSIEAGSQAVEEMESETEEE
TIFGSWFWAGKE-----VSEEAGPCCVSKSEDD-EEMI----------------------
-IESWFWSGDKATKETGTVATCESKPENEEGAIVGSWFEAEDEVDNRTDNGSNCESRTLA
DEDEAIVGSWFWAGDEAHFGS-NPSPVFRAICRSTSSVEQKPDPSRRPQSWEEVTVQFKP
-GPW----GRVGFPSISPFRFPKEA-ASLFCEMFGGKPRNVVLSPEG----E--DQESLL
QPDQ--PDPEFPFQYDPSY--------------------RSVQEIREHLRAKESAEPESW
SCSCIQ-----CELKIGSEEFEELLLLMEKIRDPFIHEISKIAMGMRSASQFTR------
----------DFIRDSGVVSLIETLLNYPSSRV------RT-RFLENMIRM-APPYPNLN
MIQTYICKVCEETLAYSVDSPEQLSGIRMIRHLTITTDYHTLVANYMSGF-LSLLATGNT
K-TR-FHILKMLLNLSENLLMTKELLSAE---AVSEFMGLFNREETN----------DNI
QIVLAIFENIGNNIKKET-VFT---------DDDFNL--EPLI-SAFHKVEKFAKELQGK
TDNQNDPEGDQEN-----------------------------------------------
-------------------------------------------

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---------------------------------------MTGTKN--KTRAQSA------
-IQAKAGEEREATGV------VRPV---------------------AKTWAKAKDKPGSL
-----TDAV---------------------------------------------------
------AEMKAV-------------SKNKVVAEMKEGALSEPKALGKAI-----------
-----GDF----------------------------SPKARNESTSSTCENGA-----VW
AEEE------------------------ATI-------KEAGN-HSSA------------
---------KNDKP--------EIGAQVSA----E-------------------------
------------ELEPVAGASCKPRSGAEE------------------------------
EEEENVIGNWFWEGDGTSFNP-NPKPESRIVKPQP---PKDCS---------EVTIWPKS
PA-------ITPAVS-QASEASPPS----YIVLGLAEEISYSWPVA-------AACPSRN
TCSCSQPVPE------------------------------------------EVNGIKPF
ACPCKM------ECYVDPEEFEKLVSLLKSTTDPLVHKRAQIAMGIHNIHPFVQ------
----------EFIN---------------------------------------EMDERQH
KIELHVKHMCKDTTSFPLNSPGQQSELKILGQLTMDFVHHYIVASDFSEL-FHLPSSGKY
K-AR-NLVLKVILNMPENPTAARDTINMK---ALAASKLIFNHKEAK----------TNL
VSGVAVFINIKEHIRKGSIVVVD----------HLSY--NTLM-GIFREVKGIIETM---
------------------------------------------------------------
-------------------------------------------

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---------------------------------MGRSREAGWV-AG----------LVLG
AGACYCVYRLA--WGSEK-SRKMA---------TACE--S--------------------
------------------------------------------------------------
------------------------------------------------------------
--R----------------G--------CPAGA---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------GLTLLQRASR
LP---------------VVSSP------------SSPAED--------------------
-----------------------------------------------------------N
CTKSS--------TILDAQHLKKLICLLESTEDPLMRERALITLGNSAAFSINQ------
----------DIIRNLDGLSVIGNILKDPNPKV------KE-KALNALNNL-SMNVLNQR
EIKVYISQICEETISSPLNSNVQLAGLRLLTNMTVTNDYQHLIANSISDL-FNLLSVGNE
N-TK-IQTLKVLLNLSANPAMARELLSVQV---PSSLISLFVGNIEN----------EIL
LRVLTLFLNLNYSIKQKENEFA---------QDQFDN--DSLFCLLYGESTECTEKLLSL
L-YHHDVKVREKVAKIITML----------------------------------------
-------------------------------------------

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---------------------------------MGGARDVGWVAAG----------LVLA
AGACYCFYRLT--RGRRR-GVP---------GLRLRP--SR-------------------
------------------------------------------SAG---------------
------------------------------------------------------------
---------------------------------SLE---EG-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------TP-------------------------------
------------------EGQ-F-------------------------------------
GG---------------TLKSP------------WSK-----------------------
---------------------------------------------------------DLT
NGSYD--------DILNAEQLQKLLYLLESTEDPVIIERALVTLGNNAAFSVNQ------
----------VTIRELGGIPIIGSKINNPNQSI------KE-KALNALNNL-SVNVENQI
KIKVYVSQVCEDVFSGPLNSAVQLAGLRLLTNMTVTNDHQHMLSCYITDL-FHLLLTGNG
G-TK-VQVLKLLLNLSENPAMTDGLLGAK---VDSSFLSLYDGHVAK----------EIL
LRVLTLFQNITTCLEKEGRLAI---------QPTFTE--GSLFYLLYGE--ECAQKMRAL
V-YHHDADVKEKVTM-IPKNW---------------------------------------
-------------------------------------------

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----------------------------------------------------------WH
SGSCCNLS--A--LGAEV-G----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------GSPE---------------------
--------------AR-------------------------------------K---DLT
SGSYD--------DVLNADQLQKLLYLLKSTEDPIIIERALVTLGNNAAFSPNQ------
----------AIIRELGGIPIVGNKINSPNQSI------KE-KALNALNNL-SVNVENQT
KIKVYINQVCEDVFAGPLNSPVQLAGLRLLTNMTVTNDHQHLLHSYIIDL-FQVLLTGNG
N-TK-VQVLRLLLNLSENPAMTEGLLSAQ---VDSSFISLYDGHVAK----------EIL
LRVLTLFQNINNCLKMEGRLAI---------QPTFTK--GSLFFLLYGE--ECAQKIRAL
V-HHHDAEIKEKVVTIIPKI----------------------------------------
-------------------------------------------

------------------------------------------------------------
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-----------------------MIGSTAKAKGREETGASAKPG--------SK------
---------KGKAKSQTKKVV-----ETEPKEELG----NQTEARGKAMARTQTVTHTEP
--ETVTWKVKKK------------------------------------------------
------------------------------------------------------------
-----------KDKTSIIVKAQTKTELLK-EPGLVPHSKSDASPMSVV--ITVTKSEVKV
D-----------------------------------------------------------
-------AAIEASSKCSAKAS-----DKGNMKHKPEI-----------------------
--------KKEICVKSG----------A--------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------GSKTSIVI-----------------------------NTTDDDDEYVCSWFW
TGEE------------------------PSVGSWFWPKDEYPLQV---------------
-----YQPPLK---------------------V-EEEP----------------------
------------------------------------------------------------
----------------------EP-AD-----------------------TFDFTLKKKA
-AAW----ARG--RFIVLVPVE------------EG--ERS-LPP---------EGNWTL
VDTLIET--------PLGVRPLTKIPPFEGPYFQTLAE------IKEQIREREKYGPNPK
TCRCKS-----RTFSLEPVEFDKLVDLLRLTRDPFIHEIATMIMGISPAYPFTQ------
----------DIVHDVGITVMIENFVNNPNAKK------YP-RNLNVS-VS-TDASDEAK
ENEAHVNKVCRDILCCPLNCSVQVEELKLLASLSIKFDYHHVIVNYVRYF-ITLLSKGSV
K-IK-FQILRVILYLSKNQANTRELISAE---VLSSLVALFHKNESK----------ANI
LHIIDIFENINFQFKKRAKLFTK--------EM-FTK--SELI-SIFHEAKEFDQKLSDL
A-EHSDPDVRDKVIRLILKL----------------------------------------
-------------------------------------------

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---------------------------------MGYARKVGWVTAG----------LVIG
AGACYCIYRLT--RGRKQNKEK-MA----EGGSGDVD--DAG----------------DC
---------------------------------------------------------SGA
--RYNDWSDDD-------------------------------------------------
DDS----------------N--------E-------------------------------
------------------------------------------------------------
-SKSIVWYPPWAR-----------------------------------------------
------------------------------------IG----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------T--------------------------------
-----------EAGTRARARA---------------------------------------
------------------------------------------------------------
-------------RARAT---------------------------RA----RRAVQKRAS
PNSDD--------TVLSPQELQKVLCLVEMSEKPYILEAALIALGNNAAYAFNR------
----------DIIRDLGGLPIVAKILNTRDPIV------KE-KALIVLNNL-SVNAENQR
RLKVYMNQVCDDTITSRLNSSVQLAGLRLLTNMTVTNEYQHMLANSISDF-FRLFSAGNE
E-TK-LQVLKLLLNLAENPAMTRELLRAQ---VPSSLGSLFNKKENK----------EVI
LKLLVIFENINDNFKWEENEPT---------QNQFGE--GSLFF-FLKEFQVCADKVLGI
E-SHHDFLVKVKVGKFMAKLAEHMFPKSQE------------------------------
-------------------------------------------

------------------------------------------------------------
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---------------------------------MSRVRDAGCVAAG----------IVIG
AGAWYCVYKYT--RGRDQ-TKKRMA----KPKNRA--VAGTGARARAGLRAGFTIDLGSG
FSPPTPVRAEAEDR-AQDEASVLDTAGAEAVAPAA------SSAEAQSGAGGQAQEADGA
--RVGPKA-ESIVGAAMASTIAPPPGVTEAL------------GAAEAHAMTGAPKVAEA
PRE----------------A--------ETSRAA-VPPGTVVPTEA-AA-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------PTEVTEAPG------------VAAPT---------
---------KVS---EAP------------------------------------G-----
-VTSPTEAAEAPVPATP------------------------------TG-----AA----
---AP-----------T-GAA-----------------E-SP------------------
----------------------GTSGSPR-------------------------------
-----------TAVVPGTSAAKKATPGAHTGAIPKATS--ATGA---VPKGGA-------
-----------KGVTRSRNGG-K----GKGK-------------K-SKVEVDELGMGFRP
GD---------GAAAAAAASAN------------GGQAFLAEVPDS-----EEGESGWTD
TESDSDSEPETQRRGRG----------------------------RR----PVAMQKRPF
PYEID--------EILGVRDLRKVLALLQKSDDPFIQQVALLTLSNNANYSCNQ------
----------ETIRKLGGLPIIANMINKTDPHI------KE-KALMAMNNL-SENYENQG
RLQVYMNKVMDDIMASNLNSAVQVVGLKFLTNMTITNDYQHLLVNSIANF-FRLLSQGGG
K-IK-VEILKILSNFAENPDMLKKLLSTQ---VPASFSSLYNSYVES----------EIL
INALTLFEIIYDNLRAEVFN-----------YREFNK--GSLFY-LCTTSGVCVKKIRAL
A-NHHDLLVKVKVIKLVNKF----------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
---------------------------------MGGPRGAGWVAAG----------LLLG
AGACYCIYRLT--RGRRR-GDR---------ELGMRP--SK-------------------
------------------------------------------SAGET-------------
------------------------------------------------------------
--A----------------G--------CPAGGILE---EG-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------TS-------------------------------
------------------KGQ-L----CGRS--------------AR---------P-QR
GG---------------TWESQ------------WSKTSQ--------------------
-----------PE--------------------------------------------DLT
DGSYD--------DVLNAAQLQKLLYLLESTEDPVIIERALITLGNNAAFSVNQ------
----------AIIRELGGIPIVGNKINHSNQSI------KE-KALNALNNL-SVNVENQI
KIKIYINQVCEDVFSGPLNSAVQLAGLRLLTNMTVTNDHQHMLHNYITDL-FQVLLTGNG
N-TK-VQVLKLLLNLSENPAMTEGLLHAQ---VDSSFLSLYDSHVAK----------EIL
LRVLTLFQNINNCLKIEGHLAV---------QPTFTE--GSLFFLLHGE--ECAQKIKAL
V-DHHDAEVKEKVLTIIPKI----------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
-------MTGAEVESGVQAKPEKKAGELG--------MG-----------GVERENEVPL
VVRPKI--------------------------RPPVQLSPGAKPKTESKSTPGARSKTEL
------PVVAGA------------RPDT----------------------------EVSA
IAGVRPKI----------------------------ESPVVAGARPKTD------GRAVG
GARPKT--EARAIPGVRLKNDA--------------L--------------AWSQTEFG-
-----AEEMSQLDGASQLNAVTWPLVSADS--GSVTKSRGLSMDTELVSVDTESFSGTH-
-GQTVIQHWFGQE-EEAN------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---GGSWCYPRPRTR-EETSNESGFWSADETSAVSSLWAGEESSIRSWPREEA---YTRS
RHRAKHQ-----T--NPRSRPRSKQEAYLDS-WSGSE-----------------------
-DEAGNPFCFWTGENTSNLI----------------------------------------
---------------------SLRVREEKNTRSKLKTKREES--FESESE------DEFY
NESWFLTGEEA---------NNR-----FRHRDNEEPNGILKHR----------------
AQ----KDVKNSDRAEQESRY-----EEEVIFGSWFWTEKEA------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------SL
EAG------ASAICDSESGPE-----EGAI------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------GGSLFWTEEKS
NLGA--------------------------------------------------------
-----------------------------------------------LAREEARPES---
------------------------------------------------------------
------------------------------------------------------------
-EEEAIFGSWFWDRDEACFDL-NPSPVYRVNCRFGDSVEEEPNVSSRPKSWDEVTVQFKR
--PC----RVIGFPPLTSFRISERSY-----EAVEAKHKNMELSPER----E--EEELLF
EPDQ--LASVFPFQYDPSY--------------------RSVQEIREHLRIRENAEPENW
YCSCIQ-----CELKIRAGEFEELLLLMDKIQDPFIQEISKIAMGMRSASQFTR------
----------DFIRDSGVVSLIETLLNYPSSRV------RT-SFLENMVHM-APPYPNLN
MIETFICQVCEETLAHDVDSLEQLTGIMMLRHLTMTADYHTLIANYMSGF-LSLLTKGNA
R-TK-FHVLKMLLNLSENFKVAKKLFSAK---ALSIFVGLFNIEETN----------DNI
QIVIKMFKNISNIIRSGAMAFID---------DDFSL--EPLI-SAFHEFEELAKQLQVQ
IDNQNDPEVGQQS-----------------------------------------------
-------------------------------------------

------------------------------------------------------------
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---MA-----------S-GAA-----------------E-AP------------------
----------------------GTSGPPR-------------------------------
-----------TTA-----AAKKATPGAHTGAIPKAGP--ATGA---VPKGGA-------
-----------KGGNRSRAGG-K----GKSK-------------K-SKVEVDELGLGFRP
GD---------GAAAAAAACAN------------GGQAFLAEVPDS-----EEGESGWTD
TESDSDSEPEIQHRGRG----------------------------KR----PVHMQKRPF
PYEID--------EILGVKDLRKVLALLQKSDDPFIQQVALLTLSNNANYSCNQ------
----------ETIRKLGGLPIIANMINKTDPHI------KE-KALMAMNNL-SENYENQG
RLQVYMNKVMDDIMASNLNSAVQVVGLKFLTNMTITNDYQHLLVNSIANF-FRLLSQGGG
K-IK-VEILKILSNFAENPDMLKKLLGTQ---VPSSFSSLYNSYVES----------EIL
INALTLFEIIYDNLRAEVFN-----------YREFNK--GSLFY-LCTTSGVCVKKIRAL
A-NHHDLLVKVKVIKLVNKF----------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------MGRARE--VGWMA
AGLM----IGAGACYCVYKLTI------------GR--DDSEKSEE------E-EEEWDD
ERELDDEEHEIWFDLTTTARPWSEDGHWTEPGAPGGAEDRPSGGGKASRT--YLVKQRPF
PYEHK--------NTWSAQSFKNFSCALGLSKEPFIQGKVLLAEPKDAGFSFSH------
----------DINSHLASLSIAGNTIPTPDPAV------EDGKALCGPDNL-NAGVENQG
QMKTCLSQVCRETVSLCCNSFLQQAGLNLLISMTVINN---MLAKSVSGLMLPLIPEGSE
C-AE-GQVVKPLTGLSEKPALSGELLRAQ---VLCPFVPLFVRNTNR----------QLL
SETLAS------------------------------------------------------
------------------------------------------------------------
-------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------MTGAEIEPSTQAKPEKKAGEEVG--------G-----------GTERENDVQM
VVRPKV--------------------------RTQTQAMPGARPKTESKAMNGARPKTES
------KA------------VNGARPKT----------------------------ESQA
MSGARRKT----------------------------EPQAVVGARPKTE------ARAVG
GARPKT--EAKAIPGARLKDEA--------------Q--------------AWAQAEFG-
-----AEAMSQTEGMPQTNAAAWPLVSTES--GSVAKPIALSVDRELVNVDPETFPGSQ-
-GQSGIQPWFGSG-EETN------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---MGSWCYPRPRAR-EEASNESGFWSADEASTMSSLWAGEEATIRSWPREEA---STRS
RHRAKHQ-----P--NPRSRTRSKQEPYVDS-WSGSE-----------------------
-EESGNPFCLWPGENANNLF----------------------------------------
---------------------RPRVRDEANAKSKLRTKKEDF--FESESE------DEYY
NESWFLPEEI----------INR-----FRPRDKEEPNTALKPR----------------
AQ----KDD-NSNKVKHEPKF-----EEDVIIGSWFWAEKEA------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------GV
EAG------ASAICESMSGAE-----EGAI------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------GGSLFWTEEKS
SLGA--------------------------------------------------------
-----------------------------------------------VAREETRQES---
------------------------------------------------------------
------------------------------------------------------------
-EEEAIFGSWFWDRDEACFDL-NPNPVYRASSRFRDLAEEGINTASRPRTWEEVTVEYKS
-SPY-----RIGFPSPSSFRIPEDA-SSAFAELFVGKPNNAE----G----E--DEESSP
QAD------QLTLECEPSY--------------------RSVREIREHLRNRESAEPESW
SCSCIQ-----CELKIGSGEFEELLLLMEKVRDPFIQEIYKIAMGTRSASQFTR------
----------DFIRDSGVVSLIETLLDYPTSRV------RT-RFLENMILM-APPYPHLN
MIETFICQVCEETFAQGLDSPEQLLGLRLLRHLTMTNDYHTLVANFMSEF-LSLLVTGDA
T-TK-FYVLKMLLNMSENPVVAKTLFSTK---ALSVFVGLFTLQESH----------DNI
QIVIKMFQNINTIMRNGKAALID---------DDFSP--VPFM-SAFHEFEKLAKALQTQ
IDNQNDPDGGQPN-----------------------------------------------
-------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
---------------------------------MGGPRGAGWVAAG----------LLLG
AGACYCIYRLT--RGRRR-GDR---------ELGMRP--SK-------------------
------------------------------------------SAGET-------------
------------------------------------------------------------
--A----------------G--------CPAGGILE---EG-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------TS-------------------------------
------------------KGQ-L----CGRS--------------AR---------P-QR
GG---------------TWESQ------------WSKTSQ--------------------
-----------PE--------------------------------------------DLT
DGSYD--------DVLNAAQLQKLLYLLESTEDPVIIERALITLGNNAAFSVNQ------
----------AIIRELGGIPIVGNKINHSNQSI------KE-KALNALNNL-SVNVENQI
KIKIYINQVCEDVFSGPLNSAVQLAGLRLLTNMTVTNDHQHMLHNYITDL-FQVLLTGNG
N-TK-VQVLKLLLNLSENPAMTEGLLHAQ---VDSSFLSLYDSHVAK----------EIL
LRVLTLFQNINNCLKIEGHLAV---------QPTFTE--GSLFFLLHGE--ECAQKIKAL
V-DHHDAEVKEKVLTIIPKI----------------------------------------
-------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
---------------------------------MSRVRDAGCVAAG----------IVIG
ASAWYCVYKYA--RGRNQ-TKKRMA----KPKTRA--VAGTGARARAGLRAGFTIDLGPG
FSPPTPVRTRAEDR-AQDEASALDAAGAEAVAPAV------SSAEAQSGAGNQVQEAEGA
--GVGPEA-EPAVGATTASSVAPPPGEAEAS------------VAAEVPTVARAPKLPEA
PGT----------------A--------EAPGAPAVLPRAPAPTEA-AA-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------PTEVAEAPV------------PATPP---------
------------------------------------------------------------
------------AAPVP------------------------------SG-----AT----
---VP------------TGAA-----------------E-AP------------------
----------------------GTSGSPR-------------------------------
-----------AAA-----PSKKATPGAHTGAIPKTGS--ATGA---VPKGGA-------
-------K-----GTRSRTGG-K----GKGK-------------K-NKVEVDELGLGFRP
GD---------GAAAAAAASAN------------GGQAFLAEVPDS-----EEGESGWTD
TESESDSEPETQQRGRG----------------------------RR----PVPMQKRPF
PYEID--------EILGVRDLRKVLALLQKSDDPFIQQVALLTLSNNANYSCNQ------
----------DTIRKLGGLPIIANMINKTDPHI------KE-KALMAMNNL-SENYENQG
RLQVYMNKVMDDIMASNLNSAVQVVGLKFLTNMTITNDYQHLLVNSIANF-FRLLSQGGG
K-IK-VEILKILSNFAENPDMLKKLLSTQ---VPSSFSSLYNSYVES----------EIL
INALTLFEIIYDNLRAEVFN-----------YREFNK--GSLFY-LCTTSGVCVKKIRAL
A-DHHDLLVKVKVIKLVDKF----------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------MVCRLDSAVQMAGLRLLTNMTVTNHYQHLLSYSFPDF-FALLFLGNH
F-TK-IQIMKLIINFTENPAMTRELVSCK---VPSELISLFNKEWDR----------EIL
LNILTLFENINDNIKSEGLASS---------RKEFSR--SSLFF-LFKESGVCVKKIRAL
A-NHNDLVVKVKVLKVLTKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MGRTREAGCVAVG----------MVIG
AGACYCVYRLT--WRKDE-NEKTWD----DDDEESSD--TSE------------------
-----------------------------TGVETE------KGAKINVGVGVGAKPQSDT
-----------------------------KA------------KAEVRLGLESGPGVKKE
SHC----------------G--------SQSGGGLE---AKA------------------
-----------------KALFNI-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------L----------------------------------
----------------KEQASAKVGKGGRVGNIS--------------------------
---------------------------------------------GNRTLAPSLPCPGGR
GG---------GCHSAKSGARA---------------------------------GSKAS
GKSKGKARSKSTRALP-T---------------------------TW----PVRRGKFNF
PYKID--------DILSTPDLQKVLNILERTNDPFIQEVALVTLGNNAAYSFNQ------
----------NAIRELGGVPVIAKLIKTKDLII------RE-KTYNALNNL-SVNAENQG
KIKTYISQVCDDTMICRLDSAVQMAGLRLLTNMTVTNHYQHLLSYSFPDF-FALLFLGNH
F-TK-IQIMKLIINFTENPAMTRELVSCK---VPSELISLFNKEWDR----------EIL
LNILTLFENINDNIKSEGLASS---------RKEFSR--SSLFF-LFKESGVCVKKIRAL
A-NHSDLVVKVKVLKVLTKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MTGAKN--EGRNKAKTQKR-A
SLQAE--AKREATGV------VRPV---------------------AKTQDKAIAKPGSQ
-----ADAA---------------------------------------------------
------AAMKAK-------------SRNKIVTERRERALADFSPKARDEATK---VSGIC
SV---AEA----------------------------NAET-----KSTCKDKAGIGTWFW
TGEE------------------------ANVGSWFWDGEEASN-RSSA------------
---------KDEGK-------AGIGSPSCA----E-------------------------
------------KLESVAEASCKAKQGTEE------------------------------
EEEENVIGNWFWDGDETSFDP-NPRPVSRIVRPQP---VDEINEKNRPKDWSEVTIWPKA
PAVTP---AVLGFRSQVPFETKPPS----YIVLASAEENAHSLPVA-----T--TCPSRS
TTSCSQPVPEYPFGSDPCI--------------------QTIEEIRRQIRIREMNGIKPF
ACPCKM------ECYMDSEEFEKLVTLLKSTTDPLIHKIAQIAMGIINVHPFAQ------
----------EFINEVGVVTLIESLLSFPSSEI-------RKKAIITL-NP-PSGDERQR
KIELHVKHMCKETMSFPLNSPGQQSGLRILGQLTTDFDHHHIVANYFSEL-FHLLSLGNR
K-TR-NLVLKVLLNMSENPAAARDMINAK---ALAALKLIFNQKEAK----------ANL
VSAVAIFINIKEHIRKGSIVVVD----------HMSY--NTLM-AIFREVKVIIETM---
------------------------------------------------------------
-------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MGGARDAGWVAAG----------LVLG
AGACYCIYWLT--RGPRR-ARR-----------RLRP--SR-------------------
------------------------------------------SAE---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------DLT
DGPYD--------AVLNAEQLEKLLYLLESTDDPIIVEKALVTLGNNAAFSTNQ------
----------AIIRELGGIPIVANKINSPNQSI------KE-KALNALNNL-SVNVENQV
KIKVYVQRVCEDVFADPLNSAVQLAGLRLLTNMTVTNNYQHLLSSYITGL-LHLLLTGNG
S-TK-VQVLKLLLNLSENPDMTEGLLSAQ---VDASFLSLYDGRITS----------EIL
LRALTLFQNLNNCLRVEGCLAA---------QLPFAK--GSLFSLLYGE--DCAQKMRAL
A-HHHDADVKEKALAILPKF----------------------------------------
-------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------DLT
NGSYD--------DILNSQQLQKLLYLLESTEDPIITERALVTLGNSAAFSTNQ------
----------AIIRELGGIPIVGNKINSPNQSI------KE-KALNALNNL-SVNVENQM
KIKVYIGQVCEDVLSGPLDSAVQLAGLRLLTNMTVTNEHQHMLNSFLADL-FHVLLTGSG
T-TK-VQVLKLLVNLSENPAMTEGLLSVQ---VNRLHTYFVNTHICK----------FG-
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MGRTREAGCVAAG----------VVIG
AGACYCVYRLA--WGRDE-NEKIWD----EDEESTDT--SE-------------------
-----------------------------IGVETV------KGAKTNAGAGSGAKLQGDS
-----------------------------EV------------KPEVSLGLEDCPGVKEK
AHS----------------G--------SHSGGGLE---AKA------------------
-----------------KALFNT-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------L----------------------------------
----------------KEQASAKAGKGARVGTIS--------------------------
---------------------------------------------GNRTLAPSLPCPGGR
GG---------GCHPTRSGSRA---------------------------------GGRAS
GKSKGKARSKSTRAPA-T---------------------------TW----PVRRGKFNF
PYKID--------DILSAPDLQKVLNILERTNDPFIQEVALVTLGNNAAYSFNQ------
----------NAIRELGGVPIIAKLIKTKDPII------RE-KTYNALNNL-SVNAENQG
KIKTYISQVCDDTMVCRLDSAVQMAGLRLLTNMTVTNHYQHLLSYSFPDF-FALLFLGNH
F-TK-IQIMKLIINFTENPAMTRELVSCK---VPSELISLFNKEWDR----------EIL
LNILTLFENINDNIKNEGLASS---------RKEFSR--SSLFF-LFKESGVCVKKIKAL
A-NHNDLVVKVKVLKVLTKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------MGRARE--VGWMA
AGLM----IGAGACYCVYRLTI------------GR--DDSEKLEE------E-EEEWDD
DQELDEEEPEIWFDFATMARPWSEDGDWTEPGAPGGTEDRPTGGGKANRT--HGIKQRPF
PYEHK--------NTWSTQNFKNFSCVLNLSKYPFIQGKMLFAQPKEAGFSFSH------
----------DISSHLASLSIGGNTIPTADPAV------KE-KAFCALDNL-NASVEKQG
PIKMYINEVCRETVSHCCNSFLQQAGLNLLISMTVINN---MLAKSVSDLKFPLISEGSG
C-AE-VQVLKPLVGLSEKAVLAGELLGAQ---MLLSFTSLFIRNGNR----------QVL
PDTLAS------------------------------------------------------
------------------------------------------------------------
-------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------MTGAEVEHGAQAKPERKPVEEG--------MG-----------GTERENEVPL
VVRPKV--------------------------RPQTQGTPGAKPKTESKSVPGARPKTES
------LAMPGA------------RLKS----------------------------EASE
IAGARPKT----------------------------ESPVMAGARPKND------GRVVG
GARPKT--EAKAIPGARPKDDS--------------L--------------AWSQTEFG-
-----AEALSQSDGAFQSNAVTWPLVSTDS--GSVSKSKDLSMDAELVDVDAESFSGIQ-
-VQTLVQPWFVLG-QETN------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---GGSWCYPTPRTR-EQVCNESGFWSADETSAVSSLWAGEETSVRSWPREEA---NTRS
RHRAKHQ-----T--NPRSRPRSKQETYFDS-WSGSE-----------------------
-DEASNPFCFWAGENTNNLF----------------------------------------
---------------------RSRVREETNTRSKLRTKREDC--FESESE------DELY
KESWFLPGEEA---------NSR-----FRPREKEEPNDILKPR----------------
AQ----NDVKNSDRTEQEPRY-----EEEVIIGSWFWAEKEA------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------NL
EAG------ASAICDSESGAE-----EGAI------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------GGSLFWTEEKS
SLGA--------------------------------------------------------
-----------------------------------------------LAKEEARPES---
------------------------------------------------------------
------------------------------------------------------------
-EEEAIFGSWFWDRDEACFDL-NPSPVYRVKCRFGDSVEEEPKVSSRPQSWDEVTVRFKR
--PC----RVFGFPPLTSFRIPEGSY-----EAVETKPKNLELSSEG----D--EEDFLF
EPDQ--LESVFPFQYDPSY--------------------RSVQEIREHLKIKESADPENW
ACSCIQ-----CELKIGAGDFEELLLLMDRIQDPFIQEISKIAMGMRSASQFTR------
----------DFIRDSGIVSLIETLLNYPSSRV------RT-SFLENMVHM-APPYPNLN
MIETFICQVCEETLSHGVDSLEQLTGIMMLRHLTMTTDYHTLIANYMSGF-LSLLTTGNA
R-TK-FHILKMMLNLSENLKVAKKLFSAK---ALSVFVGLFNIEETN----------ANI
QIVIKMFQNISNIIRSGALAFID---------DDFSL--EPLI-SAFHEFEELAKQLQVQ
IDNQNDPEVGQQS-----------------------------------------------
-------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MGGARDVGWVAAG----------LVLG
-GACYCIYRLT--RGRWR-VGR---------GPRLRP--SP-------------------
------------------------------------------SAE---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------DLT
DGSYD--------EVLNAEQLQKLLYLLESTEDSVIIERALVTLGNNADFSANQ------
----------AIIRELGGIPIVGDRINNPNHSI------IE-KALNALNNL-SVNVENQD
IIKIYINQVCEDVFSDPLNSAVQMAGLRLLTNMTVTNDHQHMLNSYLTDF-FHVLLTGNG
N-TK-VQVLKLLLNLSENPAMAEGLFGAQ---VDSSFLSLYDSRVAK----------EIL
LRALTLFQNLNNCVKKDGHLVLRF-------TSTFHK--GSLFFLLYGE--ECAQKMRAL
A-NHPDVDVTEKVVIITIQF----------------------------------------
-------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------MTGAEVAPSAQAKPEKKAEEEV--------MP-----------GAERENDVPL
VVRPKV--------------------------RTQ--ATTGARPKTETKSVPGARPKTEA
------QTMSGA------------GPKT----------------------------DPQV
MGGARPKN----------------------------EAQGKAGARPKTN------ARAVG
GARPKT--DAKAIPVARTKNEA--------------Q--------------AWDQTEFG-
-----TEAVSQAEGVSQTNAVAWPPATPES--GSVTKSKGLSMDRELVNVDAETFPSAQ-
-DQKGIQPWFGPE-EETN------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---MGSWCYSRPRAR-EKASNESGFWSADETSTMSSFWAGEETSVRSWPREES---NTRS
RHRAKHQ-----T--NPSSGPRPQQEAYVDS-WSGSE-----------------------
-DEAGNPFS-WAGENTNNLF----------------------------------------
---------------------GPRVKEEANIRSKPRTKREDC--FESESE------DEFY
KQSWVLPGEEA---------NSR-----FKRRDKEDPNTNLKSR----------------
AQ----KDV-NGDRVKQEPRF-----EEEVIIGSWFWAENEA------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------SL
EGG------ASAICESEPGTE-----EGAV------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------GGSLYWAEEQS
SLGA--------------------------------------------------------
-----------------------------------------------VARQEAKPES---
------------------------------------------------------------
------------------------------------------------------------
-EEDAIFGSWFWDRDEACFDL-NPCPVYKVSDRFRDTAEEELNASSRPQTWDEVTVEFKP
-GLF----HGVGFPSTSPFRFTEDAS-----EMFEAKPKNLELSPEG----E--EQESLL
QPDQ--PSPEFTFQYDPSY--------------------RSVREIREHLKTRESAESESW
SCSCIQ-----CELKIGPEEFEELLILMDKIRDPFIQEISKIAMGMRSASQFTR------
----------DFIRDSGVVSLIETLLNYPSSRA------RT-SFLENMIHM-APPYPNLN
MIETFICQVCEETLAHSVDSLEQLTGIRMLRHLTMTIDYHTLIANYMSGF-LSLLTTANA
T-TK-FHVLKMLLNLSENPAVAKHLFSAK---ALSIFVGLFNIEETN----------DNI
QIVIKMFQNISNIIKSGKMSLID---------DDFSL--EPLI-AAFREFEELAKQLQAQ
IDNQNDPEVGQQS-----------------------------------------------
-------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MTGTKN--KTRAQAKTEKK-P
VTQAKAGAEREATGV------VRPV---------------------AKTRAKAKAKTGSK
-----TDAV---------------------------------------------------
------AEMKAV-------------SKNKVVAEVKEGALSEPKTLGRAM-----------
-----GDF----------------------------SSKAGNESTSSTCKNEAGIDAWFW
AGEE------------------------ATINSWFWNGEEAGN-SSST------------
---------KNDKP--------EIGAQVCA----E-------------------------
------------ELEPAAGADCKPRSGAEE------------------------------
EEEENVIGNWFWEGDDTSFDP-NPKPVSRIVKPQP---LYEINEKNRPKDWSEVTIWPNA
PAVTP---AVLGFRSQAPSEASPPS----YIVLASAEENACSLPGA------TACRPSRN
TRSCSQPIPECRFDSDPCI--------------------QTIDEIRRQIRIREVNGIKPF
ACPCKM------ECYMDSEEFEKLVSLLKSTTDPLIHKIARIAMGVHNVHPFAQ------
----------EFINEVGVVTLIESLLSFPSPEM-------RKKTVITL-NP-PSGDERQR
KIELHVKHMCKETVSFPLNSPGQQSGLKILGQLTTDFVHHYIVANYFSEL-FHLLSSGNC
K-TR-NLVLKLLLNMSENPTAARDMINMK---ALAALKLIFNQKEAK----------ANL
VSGVAIFINIKEHIRKGSIVVVD----------HLSY--NTLM-AIFREVKGIIETM---
------------------------------------------------------------
-------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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---------------------------------MGNAR-RAVA-AG----------LVLG
AGVCYCVYRLY--RSRRA-AGAAA------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--R----------------P--------AQDGG-LL------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------PQV-----------------S-GLSV------
LP-----------------SRA------------WGAPSS--------------------
-----------LH-------------------------------------------PDTD
LPKSS--------SNLEAHHLQRLIHLLESTDDPLIQEQALVTLSNSAAFSVNQ------
----------DIIRNLDGLSIIGRMLSDSIPKV------KE-KALNTLNNL-SMNVKNQE
EIKVYILQVCKEIELSPLNSDLQLAGLRLLTNMSVTNDYHHMMTNAIPYF-LHLLSEGNE
R-TQ-IQVLKVLVNLSANPVMTRHLHSAQLDP-APSLLSLFDNGINK----------DIL
LRVLTFAANLNENMKNEEGIIT---------QDRYSE--DSIFFLLSGHSTQYAQKLLGL
L-HHQDKEVKGQAAKIITLQRGDIQSPN----P----LLLFC------------------
-------------------------------------------

------------------------------------------------------------
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-----------------------MIGSKTKARAREEAGATSNPG--------ISGL----
------ANTKVKAKSQTKAVV-----EAKPKQKLG----NQAEARDEAMVRTQTVICTEA
--DSVTLEVCKI------------------------------------------------
------------------------------------------------------------
-----------EDMTNIRVTTQSETELLP-EPGLVIQTKSEAMPVSMV--ITVTKSGVRV
D-----------------------------------------------------------
-------TGIEAHIKCSAKAN-----DKSGIGCRSKI-----------------------
--------KEQASISSR----------AG-------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------DKTSIVS-----------------------------SSTDEDEENVCSWFW
TGEE------------------------PSIGSWFWPKEETPFQV---------------
-----YMPPPK---------------------I-EEKP----------------------
------------------------------------------------------------
----------------------KSPEK------------------------HNFTLKEKA
-AAW----ARA--RYIVLVPVE------------GG--EQS-LPP---------EGNWTL
VATLIET--------PLGIRPLTKIPPYNGPYFQTLAE------IKNQIRQREKYGPHPG
ACRCKS-----RSFSLEPKEFDELVALLKLTKDPFIYEIATMIMGISPAYPFTQ------
----------DIIHDVGITVMIENLINNPNVKK------HT-KTLNTVSDN-SESSEEPK
GNESQIHQICKGIISCPLNSSVLVDELKLLVNLSGKPENHHVIANYIPEF-LILLNKGSV
K-TK-FHVLKVFLCLSKNQANTRELISAE---VLSSLVALFNKNESK----------ANI
LNVIEIFENINFQFKKRTKLFTK--------DK-FTK--SELI-SIFQEAKGFGQKLQNL
A-EHSDPEVKDKVIRLILKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
---------------------------------MGYARKVGWVTAG----------LVIG
AGACYCIYRLA--RGRKQNKEK-MA----EGGSADVD--DAG----------------DC
---------------------------------------------------------SGA
--RYNDWSDDD------------------------------------------------D
DDS----------------N--------E-------------------------------
------------------------------------------------------------
-SKSIVWYPPWAR-----------------------------------------------
------------------------------------IG----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------T--------------------------------
-----------EAGTRARARA---------------------------------------
------------------------------------------------------------
-------------RARAT---------------------------RA----RRAVQKRAS
PNSDD--------TVLSPQELQKVLCLVEMSEKPYILEAALIALGNNAAYAFNR------
----------DIIRDLGGLPIVAKILNTRDPIV------KE-KALIVLNNL-SVNAENQR
RLKVYMNQVCDDTITSRLNSSVQLAGLRLLTNMTVTNEYQHILANSISDF-FRLFSAGNE
E-TK-LQVLKLLLNLAENPAMTRELLRAQ---VPASLGSLFSKKENK----------EVI
LKLLIIFENINDNFKWEENEPA---------QTHFSE--NSLFF-FLKEFQVCADKVLGI
E-SHQDFLVKVKVGKFAAKLTERMFPKSQE------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
---------------------------------MGYARKVGWVTAG----------LVIG
AGACYCIYRLT--RGRKQNKEK-MA----EGGSGDVD--DVG----------------DC
---------------------------------------------------------PGA
--RYNDWSDDD-------------------------------------------------
DDN----------------S--------E-------------------------------
------------------------------------------------------------
-NKGIVWYPPWAR-----------------------------------------------
------------------------------------IG----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------T--------------------------------
-----------EAGTRARARA---------------------------------------
------------------------------------------------------------
-------------RARAT---------------------------RA----RRAVQKRAS
PNSDD--------TILSPQELQKVLCLVEMSEKPYILEAALIALGNNAAYAFNR------
----------DIIRDLGGLPIVAKILNTRDPIV------KE-KALIVLNNL-SVNAENQR
RLKIYMNQVCDDTITSRLNSSVQLAGLRLLTNMTVTNEYQHMLANSISDF-FRLFSAGNE
E-TK-FQVLKLLLNLAENPAMTRELLRAQ---VPSSLGSLFNKKENK----------EVV
LKLLVIFENINDNFKWEENEST---------QNQFSE--GSLFS-FLKEFQVCADKILGL
E-SHHDILVKVKVGKFVAKLAENMFPKSQE------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
---------------------------------------MTGTKN--KTRAQAKTEKK-P
VTQAKAGAEREATGV------VRPV---------------------AKTRAKAKAKTGSK
-----TDAV---------------------------------------------------
------AEMKAV-------------SKNKVVAEVKEGALSEPKTLGRAM-----------
-----GDF----------------------------SPKAGNESTSSTCNNEAGIDAWFW
AGEE------------------------ATINSWFWNGEEAGN-SSST------------
---------KNDKP--------EIGAQVCA----E-------------------------
------------ELEPAAGADCKPRSGAEE------------------------------
EEEENVIGNWFWEGDDTSFDP-NPKPVSRIVKPQP---VYEINEKNRPKDWSEVTIWPNA
PAVTP---AVLGFRSQAPSEASPPS----YIVLASAEENACSLPGA------TACRPSRN
TRSCSQPIPECRFDSDPCI--------------------QTIDEIRRQIRIREVNGIKPF
ACPCKM------ECYMDSEEFEKLVSLLKSTTDPLIHKIARIAMGVHNVHPFAQ------
----------EFINEVGVVTLIESLLSFPSPEM-------RKKTVITL-NP-PSGDERQR
KIELHVKHMCKETVSFPLNSPGQQSGLKILGQLTTDFVHHYIVANYFSEL-FHLLSSGNC
K-TR-NLVLKLLLNMSENPTAARDMINMK---ALAALKLIFNQKEAK----------ANL
VSGVAIFINIKEHIRKGSIVVVD----------HLSY--STLM-AIFREVKGIIETM---
------------------------------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
---------------------------------MGYARKVGWVTAG----------LVIG
AGACYCIYRLT--RGRKQNKEK-MA----EGGSGDVD--DVG----------------DC
---------------------------------------------------------PGA
--RYNDWSDDD-------------------------------------------------
DDN----------------S--------E-------------------------------
------------------------------------------------------------
-NKGVVWYPPWAR-----------------------------------------------
------------------------------------IG----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------T--------------------------------
-----------EAGTRARARA---------------------------------------
------------------------------------------------------------
-------------RARAT---------------------------RA----RRAVQKRAS
PNSDD--------TILSPQELQKVLCLVEMSEKPYILEAALIALGNNAAYAFNR------
----------DIIRDLGGLPIVAKILNTRDPIV------KE-KALIVLNNL-SVNAENQR
RLKIYMNQVCDDTITSRLNSSVQLAGLRLLTNMTVTNEYQHMLANSISDF-FRLFSAGNE
E-TK-FQVLKLLLNLAENPAMTRELLRAQ---VPSSLGSLFNKKENK----------EVI
LKLLVVFENINDNFKWEENEST---------QNQFSE--GSLFF-FLKEFQVCADKILGL
E-SHQDFLVKVKVGKFVAKLAENMFPKSQE------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
---------------------------------MGRTREAGCVAAG----------VVIG
AGACYCVYRLA--WGRDE-NEKIWD----EDEESTDT--SE-------------------
-----------------------------TGVETV------KGAKTNVGAGSGAKLQGDS
-----------------------------KV------------KPEVSLGLEDCPGVKEK
AHS----------------G--------SHSGGGLE---AKA------------------
-----------------KALFNT-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------L----------------------------------
----------------KEQASAKAGKGARVGTIS--------------------------
---------------------------------------------GNRTLAPSLPCPGGR
GG---------GCHPTRSGSRA---------------------------------GSRAS
GKSKGKARSKSTRAPA-T---------------------------TW----PVRRGKFNF
PYKID--------DILSAPDLQKVLNILERTNDPFIQEVALVTLGNNAAYSFNQ------
----------NAIRELGGVPIIAKLIKTKDPII------RE-KTYNALNNL-SVNAENQG
KIKTYISQVCDDTMVCRLDSAVQMAGLRLLTNMTVTNHYQHLLSYSFPDF-FALLFLGNH
F-TK-IQTMKLIINFTENPAMTRELVSCK---VPSELISLFNKEWDR----------EIL
LNILTLFENINDNIKNEGLASS---------RKEFSR--SSLFF-LFKESGVCVKKIKAL
A-NHNDLVVKVKVLKVLTKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
--------------------------------------------MGRVQEVGWVTAGLAI
WAGTCYYLYRLTKRRSQSVTRLARDGSRV-KMETVVG----VQNQTLAMSEAMVGVELET
RPKDKTGSETGEGSESGSEREIKVTAIERSKANS------QAMVGAETEIQSG-------
VKSAARTLVMTDAMTLTEAK--VKAREVSMKEAMTQTDFEAGEIVKKEAVTQTK-AKAWA
LVSKTEAKKEAMTQTKAETQTLAEKETEINRVMVTQSEVLAVTKE----VVKIGTMNKTG
IVVESKTRALEETVSVLTTQSDSRFGTIVDTKKNPNAMSRAVAGMDIKSCARSQAMAKIQ
DDDMPGA--EDKRNIK---------------------------TMCKAVSKVDTRASPQP
QIVVKGRAEAMPGTRVDMEGNVTAMCKAEMGTNVRACIIQPPTVAKKQAEAMSGAR-VDI
----SVIPKAITGNVIRATAQIQAVACAQAESVPDARVKGRGNPNAMVKASAMANMRTNL
QAEALPDNSHKTRSNLSVMAKAGAGIDILSYT-QAQPVVNVQGDALPDCRIKAKSTVNAV
TKEGAQA--------MAPGQGEALPNTKGKARGKAKAKCKAGVGPDMKIYSQSQAGTKTQ
AVALPDSRVDGRGDSNAISKAGPKADHRNCGQLQTVVISQGDALPGTKNKFKAYPSAVSK
TEARTATADSAQPQVVVSSQSETLIAAKNKS-----------------------------
----------RGNRSVVPKA----------------------------------------
ETGAATTGSAQPQTVNSYKGEALPGAKNKVKGNLSAVPKTETGVVI--------------
--------------------------TGSAFPQALANFQGET------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------ITGTRTKIRGNTIAMYKPEAGAGIK--
--------------------------------------DSPQSQTVASSQDETMLGARSK
VR----------------------------------------VNYNVP-KAEIGAGTVGS
SQSWTVVSSQGETLLGARNKVRSSPSAVPKAE-----AEGGIMSSSQPQALTISQNEALL
NARNKGRGNSSAMPKAGHQKGTKVSAQQQMVASSQ-------------------------
------------------------------------------------------------
-------------------------------------DEILLGIMDKGMSRSEAEATAED
MIYAKPE--AEAMPTAQGEGEPDAQACRKTQSNVHGYYWNGIGVEDWIAAERWIKFRLQA
MDGDWENSVSWAD-ENETNIGSWSGT-GDK--AGIVSSWAVAC----DETTVKSWAGATA
ENQAALGSWVGPG-DQASGGLWAASQVNEASWAGDKV-GGSWVQAENKAIGGSWTGAENQ
VSGASWVVSGNQAIGGPWAVGQVSEVSWPAVQATGLSWVVDQTGGGSWTV--------AE
NQASGVSWAGA--------------------------GNIVSIGYWTGAVDQANA-GSWI
GT------------VDQSGSESKPRFEDQASEQ------------RPSVGSENQSSERSW
ADTADQASGGSRLGPIDQSNGASWVGTGEQAGGGSTPGSEDHSSGASWAGTRNL------
------ARGGSWTET------------------------GTIGQTGGVSKSGPEDQSSGG
SWADSGDQISGRFLVGVVDQANGESQAGP----GDLAGGEAKPVFEDQASRGRCWTN-AE
DQSCRESGLSPRDQTNAGSWPGTVNQASG------------WF-------------CTYT
G---SQTSGGESWGGIGGQHFGSARPVLTNQALCGSWAGPGSQISGVSWAVA--ADQAGG
CLKPGFGNQAIGAGFWAGAGNQPGGVSTPGSEDQS--SGGGSWTGAGVHVI---------
------------------------------------GASRPDPTDQSSGASWAGTA---S
QVSGGSWVGPG--DK-AVGCFKSGFEDQ-AHGGSTWAGAGEQTSGESWAVSRSGNE----
--------------------------ASGG------------------------------
--------------------------------SRLGSEDQASGRFLVSAEEETSEGFWFA
PGSEAFIGSWGCTREEVDTVSRPDGKDEASVESTSGPKEKTIISSEFGDE------NKAS
IGSWNRSEEAA--------CM----GSCVRAESGSDTGAAVEAE--AGAEAETEA-----
------------------------------------------------------------
------------------------------------------------------------
D-----------------------------------------------------------
------------------------------------------------------------
-----------------------TEEEAEA----------------------R-------
-------------------GE-----AGA------------------EAESGAET-----
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------GTEAGV----
--ESGAETGAEAGAEA-----------------------------GADIGTAARIGSWPW
DRPA------------------------TTKGSGLGVKKEAGIRS---------------
---WAWAFARD------V-DEDELSEASSP-DI-EEIS----------------------
-LRSLFWAESDNSNEFRSQ--------SEKD--VNFKSKIGENT-SIKDNFEA-------
-ADGVDIRSWFCTGNESRSED-KSTPKAKAKKSAE-S----------RGTYPSM-VPGAG
MGSW----DGAVIWSEMK--FQ------------HQ--NESSFPAED----E-----FR-
QQ-I-----------------------------------RA------------GEKVRPW
PCRCKR------EANLDPQDFEKLICMIEMTEDPSVHEIANNALYNSIDYPYSH------
----------EIVRNVGGISVIESLLNNPYPSV------RQ-KALNALNNI-SVAAENHR
QVKTYLNQVCEDTVTYPLNSNVQLAGLRLIRHLTITSEYQHMVTNYISEF-LRLLTVGSG
E-TK-DHVLGMLVNFSKNPSMTKDLLIAN---APTSLINIFSKKETK----------ENI
LNALSLFENINYHFKRRAKAFTQ--------DK-FSK--NSLY-FLFQRPKACAKKLRAL
AAECNDPEVKERVEILINKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MGYARKVGWVTAG----------LVIG
AGACYCIYRLA--RGRKQNKEK-MA----EGGPGDVD--DVG----------------DC
---------------------------------------------------------PGA
--RYNDWSDDD-------------------------------------------------
-DN----------------S--------E-------------------------------
------------------------------------------------------------
-SKGIVWYPPWAR-----------------------------------------------
------------------------------------IG----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------T--------------------------------
-----------EAGTRARARA---------------------------------------
------------------------------------------------------------
-------------RARAT---------------------------RA----RRAVQKRAS
PNSDD--------TILSPQELQKVLCLVEMSEKPYILEAALIALGNNAAYAFNR------
----------DIIRDLGGLPIVAKILNTRDPIV------KE-KALIVLNNL-SVNAENQR
RLKIYMNQVCDDTITSRLNSSVQLAGLRLLTNMTVTNEYQHMLANSISDF-FRLFSAGNE
E-TK-FQVLKLLLNLAENPAMTRELLRAQ---VPSSLGSLFNKKENK----------EVI
LKLLVVFENINDNFKWEENEPT---------QSQFSQ--GSLFF-FLKEFQVCADKILGI
E-SHHDFLVKVKVGKFMAKLAEHMFPNSQD------------------------------
-------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------MTRTEFELYTEDKHEKKPEEKVV--------S-----------AAGIENEVPL
VVRPKV--------------------------RTQAQIMTGARPKTKTKVVPGTWPKT--
------------------------------------------------------------
------------------------------------------------E------ARAMG
SVYTKY--KIKKIHESRSKDDA--------------Q--------------TWALSEFG-
-----PESISKMEQESQINVIISPGVSSDS--GSVANTKCLFMDRESINIDNESFPGKKV
HSQVGFPSSFVSG-KVTD------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---SEPWSYPRHISK-QKPSQNSDFNWVDKS-VNSWFWSQEEVNGRFHPRNRIKA-STRS
KYMSKQE-----A--TNYSRHKNKQDLYIVSSSSGSE-----------------------
-DESLKTSWFCGKQKTNPLS--KSREEV-NSRSWFRSEKEVNI------------EFSPR
SEYENAMKSWFWDREETKYSTLPRTRKETNERARYSPKQEACIETMTEST------DVNQ
KESWFWPEEKG---------NTF-----LRCNTKKESRAQAMEK----------------
EE----A----RTRDKREERP-----QEETFIETWFWATEESSLMDVPSIKSSPQLKDES
IIGSWFWTEEEVSMETRSSSKS-RLEVK-ELIDNSCLGDG-EKTSIEMGAEATSQSILAA
NDE-EVIVGSWFWAGEE-VN---------------------------------PEPKEET
IFGAWFWSTDEAS-GESDVGISCE-------------------------------SRPR-
-S-AEEVIGPWLWAGE-VSIGAGVGEE----------FSQESEEETMYLSWFWSENQTSM
DSA------TEASSDVPGAEE----EEDPMFGSWFWARVDACEESTVNSKSSLEDEE--A
IISSSFVAREEANMKYGAGARCKFMAETEDT-NKSCFWAEEEPCMYHASRRNWKFRAEEE
-----EDIADSRFWSRKYTRPEALVG------------------------SWLWAAEEGS
TDYKIRQEAMLPTKEKTMTKSQFWKEDKDTTIEVTDRKESWPEAEEEDIIGSWFWSEEED
RLEAQREGREENSLGVEEEESVFRSC--GKQEAV-TESGFSSKYSSKADAEEVIVGSWFW
EQETSLEAVTADTFESKTGTEEE----EIIVGSWFWPKE-ANIEAGSQAVEETRSKTEEK
TILESC-CAKKE-----VNIEAGMCCVSKPEYD-EEMI----------------------
-VEAWFWSTDKTIKETGTVATCECRSQDDEEEVVETWCRATDEVNNGTDDGTNCESRILV
-DEEDIVGSWFWIGDEAHFES-NPSPVFRATCESWGSVKEEPDLSHRPQSWEEVTIQFKP
-GPW----GRVGFPSLSSFIFPREA-APLFSELFGE-NRHVERIAED----E--EQESFL
H-----VEPEFSFQYDPSY--------------------RSVQEVREHLRAKESAESESW
SCNCIQ-----CELRIDSEEFEELLLLMDRIQDPFIHEISKIAMGMRRASQFTR------
----------DFIRESGVVSLIETLLNYPSSRD------KT-RFLKEMILT-APSYPNLN
MIQTYVCQVCEETLAYSVDSPEQLSGLRMIRYLTTTTDYHTLVANYMSGF-LTLLATGNN
K-TR-FHVLEMLLNLSENFIMMKELLSTE---AVSEFMGLFYREETN----------DNI
QIVLAIFENIGTNIRKDTVFID--DD-----DDDFSL--EPLI-SIYHEVEKFAKQLQSK
IDNQNDPEADQEN-----------------------------------------------
-------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MGYARKVGWVTAG----------LVIG
AGACYCIYRLT--RGRKQNKEK-MA----EGGPGDVE--DAG----------------DC
---------------------------------------------------------SGA
--RYNDWSDDD-------------------------------------------------
DDS----------------N--------E-------------------------------
------------------------------------------------------------
-SKSIVWYPPWAR-----------------------------------------------
------------------------------------IG----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------T--------------------------------
-----------EAGTRARARA---------------------------------------
------------------------------------------------------------
-------------RARAT---------------------------RA----RRAVQKRAS
PNSDD--------TVLSPQELQKVLCLVEMSEKPYILEAALIALGNNAAYAFNR------
----------DIIRDLGGLPIVAKILNTRDPIV------KE-KALIVLNNL-SVNAENQR
RLKIYMNQVCDDTVTSRLNSSVQLAGLRLLTNMTVTNEYQHILANSISDF-FRLFSAGNE
E-TK-LQVLKLLLNLAENPAMTRELLGAH---VPSSLGSLFNKKEYK----------EVI
LKLLSIFENINDNFKWEENEPA---------QNHFSE--GSLFF-FLKEFQVCADKVLGI
E-SHHDFQNEHTRALRS-SHAERQRPLNGVTRS-PSVVGIFCSFSSCYS--CSSPPSLSP
SLPHSISLSLTLWSLFPLGR-----------------------

------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MGYARKVGWVTAG----------LVIG
ASACYCIYRLT--RGRKYNKEK-MA----EGGSGDVD--DAG----------------DC
---------------------------------------------------------SGA
--RYNDWSDDD-------------------------------------------------
DDG----------------N--------D-------------------------------
------------------------------------------------------------
-SKSIVWYPPWAR-----------------------------------------------
------------------------------------IG----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------T--------------------------------
-----------EAGTRARARA---------------------------------------
------------------------------------------------------------
-------------RARAT---------------------------RA----RRAVQKRAS
PNSDD--------TILSPQELQKVLCLVEMSEKPYILEAALIALGNNAAYAFNR------
----------DIIRDLGGLPIVAKILNTRDPIV------KE-KALIVLNNL-SVNAENQR
RLKIYMNQVCDDTITSRLNSSVQLAGLRLLTNMTVTNEYQHMLANSISDF-FRLFSAGNE
E-TK-LQVLKLLLNLAENPAMTRELLRAQ---VPLSLGSLFNKKENK----------EVI
LKLLVVFENLSDNFRWEENEPT---------QNQFGE--GSLFF-FLKEFQVCADKVLGI
E-SHHDFLVKVKVGKFMAKLAENMFPKIQE------------------------------
-------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------MTRAEVEPGAQAKAENKPGDENA--------N-----------AAEVEPEAPL
VVRPKV--------------------------RT--QIMTGARPKVKPKGTPGARPKG--
------------------------------------------------------------
------------------------------------------------E------TSTPG
GAYAKC--KPKAIPIARSKHDA--------------Q--------------VWAPNKFR-
-----GESMSKMGKQCQISAADPPLLSNDS--GMVAQAKCLPVDRELANMDTESIPKK-A
SSPAGFQPSFSSE-EGTN------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---MGSWYRPRPVPK-GEAYENSDFKWADKPSGSPSFWNRDEASTRFRPRKSMKA-NNRF
RHMAKQE-----A--NNMPRHKSKQEFYNIS-SSDSE-----------------------
-DESGKTPWFWPKDKTKVWS--RPKEEP-NSRSWFRSKKEVRV------------ESTSG
SECENPTKSLFWSGEEAKSRSKPRARKGVNTRARQQAKREVCSDAMSGAV------DTNK
KESWFLPEEKA---------NAF-----SKSKTKKEPRTRAVPK----------------
EE----VKTKARASTKQEARP-----EEEVLVGAWFWDTQESTMADRISIKT-TFVEEEP
IVGDWFWSEEEASVDSETCHIS-RPRAKEEQVSSFCLGSG-KKSSMESGPKATSRSLPVA
KED-EVAIGSWFWADDEEIN---------------------------------LQADDES
IFGSWFWGTGENS-LRS-VGVNCE-------------------------------KMPK-
A-GEKEVTDSWFWAGD-VNTEAEDEEQ----------ARSASTKATIFVPWFWSEKQPNM
DLG------PEPCSDIMAGAE-----EEPIIGPWFWAKVDNSVEAEVNSKSSLEDEEE-P
VRSPWFGAREQTDMKYAAGVRYKPMAEAEDANKKSCVWAK-EPCLYPTNRECLKSTLGEK
-----EGTVDPWLWSNNYPRTKTITG------------------------SWLWAADEGN
IDDETGEKIKLPTLEDNAFNSWFWKENEETIVEAPNREESRPEAEEEDIIGSWFWAGDED
RFQPAAKINEENK-IASEDEDTVGSWFWGNEE----------------------------
---ASLEAVRRGTFESAPGIKEE-----KVTGSWFWTAK-AKVGAGSQT-VETGSETEEE
AIFESLIWAAKK-----DSMQAGVKRVPKPKDE-GDVA----------------------
-VGSWLWSSDKATKEAKTPIVSEASPENGKESVVKFGSRAKDAVINKTGSGDNCKHST--
-EAETIVGAWFWEGDEASFES-NPVPVCKAICEPESSAEHEPDPSRRPQSWDEVTVQFKP
-GPW----GKAGFPSLNPFRFPKEA-ASLFAEMFGGKPKLVEVGP-E------------R
---V--PVPQFPFQYDPSY--------------------RSVREIREHLKARESAQPENW
SCNCIQ-----CELRIGSEEFEELLLLMDRNRDPFIHEISKIAMGMRSASQFTR------
----------DFIRNSGVVSLIEALLNYPSSRV------RT-RFLENMVRM-APPYPDLN
MIETYVCQICEDTFDYDLDSPDQLSGLTMITHLTATSDYHKVVVNYLAGF-FYLLNSGNT
N-TR-FQVLKLLLNLSENLVMTKRLLVTD---SVSEFMDLINREESD----------ENI
QIVLAIFETISKHIQKEALFSDDDD--DDEEEDAVNL--EPFI-SAFREAEKTAKELKRK
PGNQKAP-----------------------------------------------------
-------------------------------------------

------------------------------------------------------------
--------------------------------------------MGRIQEVGWVTAGLVI
WAGTCYYIYKLTKGRAQSVRTLARNESTV-KMETVVE----VQNQTLAIGEAE----IET
KSQAEIEAETGAGGGPGAEVETKATAIARHKANSQ----AKTMIGAEAEIQSE-------
SKVVAGTLVMTESVTLTEAK--AKAREVAMKEAVTQTDAEAGKIVKKEAVTQTK-AKAWA
LVAKTEAKREAMTQTKAETHILAEKEAEINRVMVTQSETLAVPGE----VAKMGATNKTG
IVDETKTRALEETVSVAKTQSEARPGSTVDARGNPNGMSREVAEVDMKSWAQSQAVTKIQ
GDNMPGARVEDMGNCK---------------------------TMSRQESGADMRASAQP
QIVAKTQIEAIPGAKVDAGGTTNAMCKVGAGADVRTCI-QPQTAAKKQAEVTSGAR-VDG
RGNTNVISKAITGADMRAAAQPQAVASPHAEAMSDAKVKERGNPNAMTKAGARTNLRTNS
QVEALPNAGDKSRGNPSVMAKMGDGADMLSCT-QPQLVAIVQANTLSDGRIKVKGNVNSI
PKEGSGMDMKAQ--GMAQSQGEALPNTRGKSRAKAKAKCKTGAGMDMKTCAQPQAAVKTP
AEALPDSRVDSRGNLNAISKAGTKADQRACGQPLVVANPQDEALPGAKNKAKGNPHAVPK
VGAGEGTTDSTQPQAV---------------------------------------VSFQG
EALLGTKNKVKGNPNAVLKAEVGAGAMGTAQLQIVASSKGEALLDSKNKAKGNSNAVSKA
GAGTDTMGSAQPQIVANSQSEVLPGTKNKVRGNPTTMPNSGAGPYI--------------
--------------------------TDSAQPQAVASSQGEVLPSAKNKVKANLHALSKA
EAGMGAT-----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------ASVQSQAVANSQGETLPGAKNK
VRGNWNTVSKAGAGMDTTGSAQPQAVANSQGEVLPGAKNKVKGNPNVVSKAGAREDTMGS
AQP---------------------------------------------QVVANSQHETLS
GARNKVKGNSNAISKAEAGSSIMGSVQVQVVASSHGKVLPGAKNKIRGN--SNAVPKAEA
GADTVGSGQPQAVANTQRETLLGARNKVKGNTKAVPKAGTGAGTRDSAQPQVVASSQ---
-------------------------------------GETLPRARDKAMLSSEAEATAED
EVYAKPE--AEAMPTSESEGGSGAQACRKTQPDIHDYYWNGIGVEDWIAAERWIKFRFQT
MDGDWENGVSWADDENEASTGSWSGS-SDK--AGIISSWTVAC----DETSVKSWAGARA
ENEVNIGTWVRAG-EQASGGLWVGGQTSEGTWAAD------------KASGGAWTVAENQ
ASGGAWVVTGNQAFGEIWAVGQASDGSWPGGQASGVSWVGEQAIGGSWTG--------AE
SQASGGSWAVV------------------------GAGNMSSVSYWAGVVDQASG-GSWA
GI------------SDQSGGGSKPRFEDQASGEGSWAGAGGQASGGSRLGPEEQSSGRSW
ADTADQASGGSRLGHVDQTSGG--------------------------------------
----------SWAGTLDQSGGGSKPRFENQTTEEG-SWAGAGGQAGGGSKLRPEDQSSGR
SWANSGDQISGGFLVGVVDQANGGSWTGT----GHPASGRPKPIFEDQASGGGSWA-DAG
DQAVGDSRLGPRDQSSGDSWAGTGDQASG------------WF-------------CVCP
G---SQ-MNGGSWGVASGQDVGGSRPGPTNQSSAVSWDSAGSQVSGSSWTGVRAVDQAAG
CSKPGFEDQAIGGVFWPGAGDQAGGGSRPGSEDQS--SGRGSWGVAGVQVL---------
------------------------------------GGSRPGPADQSSGGSWAGTR---N
QSSGRSWIGPG--DQ-AGDCSKPEFEDQ-ACGGGSWAGAGNQASGESWAGSRLGNE----
---AIEG-----S--KM-----------------GSE-----------------------
--------------------------DQATGGSWARSEDQASGRFQVSVEVEANEGFWFG
PGAEAVIGSWCWTEEK-VIVSRPDDKDEAITESRSGAGEEAIICSRIEAE------NKAS
SGSWIRSEEMA--------YMGSSVGAEAGAGA--------------WSWDR--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--DAGTGVGAGAEARA-----------------------------GAWLGAEAGARAWSW
DGET------------------------TTIESRLGAREEVGV-----------------
---ESWTLAWD------V-DEDDLSRESSP-DI-EEIS----------------------
-LRSLFWAESENNNKFRSK--------SGKD--VNFVSGAEDNT-RIKDKFEA-------
-AGGVDIESWFCAGNENTSED-KSAPKGKGKKSPE-S----------RGTYPSM-VPGAG
MGSW----DGAMIWSETK--FP------------HH--SEASFPVED----E-----SK-
KQ-T-----------------------------------KT------------GEKTRSW
SCHCKR------EDNMDPQDLEKLICMIEMTEDPSVHEIANNALYNSADYPYSH------
----------EVARNVGGISVIESLLNNPYPSV------RQ-KALNALNNI-SVAAENHR
QVKTYLNQVCEDTVTYPLNSNVQLAGLRLIRHLTITSEYQHMVTNYISEF-LRLLTVGSG
E-TK-DHVLGMLLNFSKNPSMTKDLLIAN---APTSLINIFSKKETK----------ENI
LNALSLFENINYHFKRRAKTFTQ--------DK-FSE--NSLY-FLFQRPKACAKKLRAL
AAECNDPEVKERVELLISKL----------------------------------------
-------------------------------------------

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---------------------------------MGGARGAGWVAAG----------LLLG
AGACYCIYRLT--RGRRR-GGR---------GLGLRP--SQ-------------------
------------------------------------------SAG---------------
------------------------------------------------------------
---------------------------------SLE---EG-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------TP-------------------------------
------------------EGQ-L----CGRS--------------AR---------P--T
GG---------------PWESQ------------WSKTSQ--------------------
-----------PE--------------------------------------------DLT
DGSYD--------DVLNAEQLQKLLYLLESTEDPIIMEKALITLGNNAAFSVNQ------
----------AIIRELGGIPIVGNKISHSNQSI------KE-KALNALNNL-SVNVENQI
KIKIYINQVCDDVLSGPLNSAVQLAGLRLLTNMTVTNDHQHMLHSYITDL-FQVLLTGNG
N-TK-VQVLKLLLNLSENPAMTEGLLRAQ---VDASFLSLYDSYVAK----------EIL
LRVLTLFQNINNCLKIEGHLAV---------QPTFTE--GSLFFLLYGE--ECAQKLRAL
V-HHDDAEVKEKVITIMPKI----------------------------------------
-------------------------------------------

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-----------------------MIGSKTKRKAREESGASSKPG--------TNSP----
------ANAKGKAKNQTTKAV-----KAEPKEEWG----NQAEARDEAVARTQPAISTEP
--KTVTWKVKKK------------------------------------------------
------------------------------------------------------------
-----------KDKTNARVMAQAKTELLA-EPALVPHTKSDALPTSVV--ITVTKSEVKV
D-----------------------------------------------------------
-------TGIEASVKGAAKAT-----DKRSIKHKPEI-----------------------
--------KKEVCVKSR----------AEDKAKEVCVKSRAGDKAKE---VCVKSRAG--
------------------------D--------------------------------K--
-AKEVC-------------------------------VKSRAGD--KAK-----------
EVCVKSRAGDKASIVI-----------------------------NTTDEDEDYVCSWFW
TGEE------------------------PSVGSWFWPKEENPLQV---------------
-----YQPPPK---------------------V-EEEP----------------------
------------------------------------------------------------
----------------------EP-PD-----------------------TFDYALKKKA
-AAW----LRG--RFIVLVPIE------------EP--QPS-LPP---------DGNWTL
VATLIET--------PLGIRPLTKIPPYGGPYFQTLAD------LKNQIREKEKYGPNPN
TCRCKS-----RTFSLEPVEFDKLVTLLKLTRDPFIHEIATMIMGISPAYPFTQ------
----------DIVHDVGITVMIENFVNNPNAKK------YP-RTLNIN-AD-PDAPEEVK
ETEAHVNKVCRDILCCPLNCSVQVEELKLLVSLSVKFDYHHVVIYYVRYF-ISLLNKGSV
K-IK-FQILRVLLCLSKNQANTRELISAE---VMSSLVSLFHKNESK----------ANI
LHIIEIFENINFQFKKRAKLFTK--------EM-FTK--SELI-SIFREAKEFDQKLQDL
T-DHSDPDVRDKVIRLILKL----------------------------------------
-------------------------------------------

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---------------------------------------MTGAKN--ETRNKGKAQKR-A
GVQAE--AKRETTGI------VRPV---------------------AKTQDKAVAKAESQ
-----ADAT---------------------------------------------------
------AAMKAR-------------CKNRSVPEIKERGLAYFSPKAEDEATK---VSRIC
SV---AEA----------------------------NAES-----GSTCKHKAGIDTWFW
SGEE------------------------ANVGSWFWSGEEANN-HSNA------------
---------KDEGK-------AGIDPLSYA----E-------------------------
------------KLESVAGASCKARPGAEE------------------------------
EEEENVIGNWFWDGDETSYDP-NPRPVSRIVRPQP---VDEINEKNRPKDWSEVTIWPKA
PAVTP---AVLGFRSQVPFETKPPS----YIVLASAEENTHSLPVA-----T--TCPSRS
TTSCSQPVPEYPFGSSPCI--------------------QTIEEIRRQIRIREVNGIKPF
ACPCKM------ECYMDSEEFEKLVTLLKSTTDPLIHKIAQIAMGIIKVHPFAQ------
----------EFINEVGVVTLIESLLSFPSSEI-------RKKAVITL-NP-PSGDERQR
KVELHVKHMCKETMSFPLNSPGQQSGLKILGQLTTDSDHHHIVANYFSQL-FHLLSLGNR
K-TR-NLVLKVLLNMSENPTAARDMINTK---TLAALKLIFNQKEAK----------ANL
VSAVAIFINIKEHIRKGSIVVVD----------HMNY--NTLM-AIFREVKGIIETM---
------------------------------------------------------------
-------------------------------------------

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---------------------------------------MTGTKN--KTRAQDKTEKK-G
YCRSRVSDR--CC-------------GR--------------------------------
------------------------------------------------------------
--------------------------------DED-EGRSSAKALGKVT-----------
-----GVF----------------------------SLKAGKESTSSLCKNEAGTDAWVW
AVEE------------------------ATINSQFWNGQEAGN-HFGA------------
---------KNDKP--------EIGAQVCA----E-------------------------
------------ELEPAAAAGCKPRSGAEE------------------------------
EEEENVIGSWFWEGDDTSFDP-NPKPVSRIIKPLP---VYEINEKDRPKDWSEVTIWPKA
PAVTP---AVLGFRSQAPSEASPPS----YIVLASAEENASSLPVA------TACHSSRN
TRSCSQPVPEGPFGSDPCI--------------------QTIDEIRRQIRIREVNGIKPF
ACPCKM------ECYMNSEEFEKLVSILKSTTDPLLHKIAQIAMGIHTVHPFAL------
----------EFINKM--------------------------------------------
-------HMCKDTI------------LKILGQPTADFVHHYIVARDKSEL-FHLPSSGKY
K-TR-NLVVKVLLNMSEHPTTARDTINMK---SLAV------------------------
----GVAIFIKAHIRKGSIVVVD-----------------TLM-DIFREFKGIVETM---
------------------------------------------------------------
-------------------------------------------

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---------------------------------MSRVRDAGCVAAG----------IVIG
AGAWYCVYKYT--RGRDQ-KKRRLA----KPKNRA--VAGTGARARAGLRAGFTFDLGPG
FSPPTTVYAATEDK-AKDEAPALDMAGAETVVPAL------SSTESQSEAEKA-------
------------------------------P------------IALEGSAVAEVPKIAEA
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------PSTAE
APRAT----------VPPGVE---MPPKA-------------------------------
-------------------------------------------AMSP----GAVVPPRA-
------------------------------------------------------------
-------------------------------------VVLPPGTAVSTKAPAATETMEAP
AVTAPTEVAEGPGMTTV------------------------------GQAAEAPVS-T-P
AGAAI-----------TARAA-----------------E-VP------------------
----------------------GTSESTR-------------------------------
-----------AAA----AVARKATPGAHTGAIPKAGS--ATGA---VPKGGA-------
-----------KGGNRSRTGG-K----G--KS------------KKSKAEVDELGMGFRP
GD---------GAAAAAAASAN------------GGHAFLAEVPDS-----EEGESGWTD
TESDSDSEPETQCRGRG----------------------------KK----TIAMQKRPF
PYEID--------EILGVRDLRKVLALLQKSDDPFIQQVALLTLSNNANYSCNQ------
----------ETIRKLGGLPIIANMINKTDPHI------KE-KALMAMNNL-SENYKNQG
WLQVYMNKVMDDIMASNLNSAVQVVGLKFLTNMTITNDYQHLLVNSIANF-FRLLSQGGG
K-IK-VEILKILSNFAENPDMLKKLLSTQ---VPSSFSSLYNSYVES----------EIL
INALTLFEIIYDNLRAEVYN-----------YREFNK--GSLFY-LCTASGVCVKKIRAL
A-NHHDLLVKVKVIKLVNKF----------------------------------------
-------------------------------------------

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-------MTRAEVETGAQAKPEKKTGEEA--------LS-----------SAERESEVPL
VVRPKV--------------------------RTQASVTPGARPKTEPKSVTGARPKTET
------QTVSGA------------R-----------------------------------
-----PKT----------------------------EGQSKTGARPKTD------NRAIG
GARPKT--ETKLINAARPKDDA--------------Q--------------AWAHSEFG-
-----SKTMSQVEATPPTNAVTWPLVSAES--GSGT----QSMDREVANVNSETLPGTQ-
-SQIGIQPWFGPG-EATN------------------------------------------
------------------------------------------------------------
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---MGSWCYPR-----EETANESGFWSADETSTLSSFWTGEETSVRSWPREEA---NTRS
RHRAKHQ-----T--NPRSRPKSKQEPYIDS-WSGSE-----------------------
-DETGNPFCFWAGENSNNMF----------------------------------------
---------------------RPRVREEANVRSKLRTKREDC--FESESE------DEFY
KE----------------------------CRDKEEPDNILKSR----------------
NQ----KDVKSGDKVKQEPRL-----EEDVIIGSWFWAEKEA------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------SL
EAG------ASAIYESESGAE-----GGAI------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------GGSLFWTEEKS
SLGA--------------------------------------------------------
-----------------------------------------------VAREEARPES---
------------------------------------------------------------
------------------------------------------------------------
-EEEAIFGSWFWDRDEACFDV-NPNPVYKANCRFRDSPEEELNASSRPQTWEEVTVEFKP
-GPC----HGVGFPS-NRFRMPEGSS-----ENTEGKPKNVEPSPEG----E--EQESLF
QPNQ--AEPEFPFQYDPSY--------------------RSVREIREHLKTRESTEPENW
SCSCIQ-----CELKIGSGEFEELLLLMDKVRDPFIHEISKIAMGMRSASQFTR------
----------DFIRDSGVVSLIETLLNYPSSRV------RT-SFLENMIHM-APPYPNLN
MIETFICQVCEETLAHGVNSLEQLTGIRMLRHLTMTTDYHTLIANYVSGF-LSLLTTGNA
R-TK-FHVLKMLLNLSENPMVAKKLFSAK---ALSIFVGLFNIEETN----------DNI
QIVIKMFQNISNIVKSGAMSLID---------DDFSL--EPLI-SAFHDFEELAKQLQVQ
IDNQNDPEAGQ-------------------------------------------------
-------------------------------------------

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--------------SLEAPDLQKLICLLE-AEDPLVREKALITLGNSAAFSANQ------
----------EIIRDFGGLPAIGNLLDDPNVKV------KE-KALDALNNL-SMNLRNQE
EIKVFIGKVCEETCSSPLNSELQLAGLRLLTNMSVTNDYQHLVADSISNF-LYLLSAGNE
K-TQ-VQVLKVLVNLSANPAMTKELLGAQA---PLSLISLLDSGVAR----------EVL
LRIVRLVANLNDHVSRKEST-A---------WRPLSE--DSLFALLYGESGLCAQKLTAL
T-RHPDPEVKEQITRITAIA----------------------------------------
-------------------------------------------

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---------------------------------MGGARDVGWVAAG----------LVLA
AGACYCIYRLT--RGQRR-GAR---------RVGLRP--SR-------------------
------------------------------------------SAE---------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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---------------------------------------------------------DLT
NGSYD--------DILNAEQLQKLLYLLESTEDPVIIEKALVTLGNNAAFSANQ------
----------VIIRELGGITIVGSQINNPNQSI------KE-KALNALNNL-SVNVENQI
KIKVYVNQVCEDVLSGPLNSAVQLAGLRLLTNMTVTNDHQHMLSTYIADL-FHVLLTGNG
S-TK-VQVLKLLLNLSENPAMTDGLLGAQ---VDSSFLSLFDGHVAK----------EIL
VRVLTLFQNIDNCLKKEGRLAL---------QPAFPE--GSLFYLLYGD--ECAQKMRAL
V-YHHDADVKEKVQL-RCDASDEEYLSQ----L-PRLQLVLSKSGGNYLNSCPEKPAII-
---------LNLRNKLPPDRKLKKARASITPPHLPPIFRSFRG

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-------------------------------------------------------MGFRP
GD---------GAAAAAAASAN------------GGHAFLAEIPDS-----EEEESGWTD
TESDSDSEPETQCRGRG----------------------------KK----TVPMQKRPF
PYEID--------EILGVRDLRKVLALLQKSDDPFIQQVALLTLSNNANYSCNQ------
----------ETIRKLGGLPIIANMINKTDPHI------KE-KALMAMNNL-SENYENQG
RLQVYMNKVMDDIMASNLNSAVQVVGLKFLTNMTITNDYQHLLVNSIANF-FRLLSQGGG
K-IK-VEILKILSNFAENPAMLKKLLSTQ---VPSSFSSLYNSYVES----------EIL
INALTLFEIIYDNLRAEVFN-----------YREFNK--GSLFY-LCTTSGVCVKKIRAL
A-NHHDLLVKVKVIKLVNKF----------------------------------------
-------------------------------------------

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------------------------------MSLLPSSHHPGWRHHQ----------SPRS
PRTCPG-------------APP-----------CARL--RL-------------------
------------------------------------------GSK---------------
------------------------------------------------------------
------------------------------------------------------------
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---------------------------------------------------------DLT
DGSYD--------EVLNAKQLEKLLYLLELTDDPIIVEKALVTLGNNAAFSANQ------
----------AIIRELGGIPIIGNKINSLNHSI------KE-KALNALNNL-SVNVENQV
KIKVYVQRVCEDVFADPLNSAVQLAGLRLLTNMTVTNDYQHLLSSYITGL-LHLSLIGNG
S-TK-VQVLKLLLNLSENPAMTEGLLSAQ---VDSSFLSFFDGHIAN----------EIL
LRALTLFQNINNCLRVEGCPAG---------QPPFAK--GSLFSLLYGE--DCAQKMRAL
A-HHHDVDVKEKVLAIMPKGIQVCTLGQ----L-VNQAARL-------------------
-------------------------------------------

------------------------------------------------------------
--------------------------------------------MGRVQDVGWATAGLVI
WAGTCYCIYRLTKGRSQSGSRFARNGSRI-ETETEVG----VQNQTVATGEAMAGAETRV
K----TEPETGEGGEPVAEADPKVPVLARASINCQ----TETMLEEEVETHSE-------
TSSLVETVVMTDAVTFTEATATAKAKEVTMKEAVTQTEVETEEVGKKEAVTQTK-AKAWE
MAGRAEVKKEAMTQTKAEAPPLAEKETEINRVTVTQSEVLAVTKE----VVKIGTMNETG
IVAEATIRTLEETVSVTRTQSETRLGVTVDTNENPIDMPLVVAGVDVESYAQSQVVDIIQ
NDDMIGDEVDDKGNLK---------------------------STSEAGSGVDTKASDQP
PIVANIPAEAMPGARDDACDNTNDICEAE--ADMTTCIIQPETVATIQAETTSGATTTDD
REDANGEFKAVTGADITD-TDPQAVTSDQTEAMPDAKVKGKGNDTAMANAGTKANTETSL
QTDALPDTEDKNISDPNDVAKAEASRDVVFCT-QTEPVANAK------------DNANTT
SKEGVQ--------ATAQSQGEALPNTKGKARGKAKAKCKAGAATDVKTCAQPQAGTKTQ
AEALSDSKVDSKSDSNAASKAGAKAD-----------SCQNEALPGTKNKVKGNSNPVPK
AEAGTAAVGSAQT-----------------------------------------------
------------------------------------------------------------
------------NVVTGSQGESASGAKNKVKGNRNSVPKAGAGPDP--------------
--------------------------TDSAQSQTVATSHSENLPGAKNKVKSNPNVVPKA
EAGVGACPQSA-------------------------------------------------
------------------------------------------------------------
--------------------------AISQGVALTGTKTKAKGNSSAGSKPDAGAGTM--
------------------------------------------------------------
----------------------------------------------------------GS
V--KAVVSSQGEAGPGSKSKVKGNPNAVPKAE-----AGASTI-----LALASSQAEALL
GARNKVRGNSNTVPKAEAGSGARGSVQS--------------------------------
----------QAVVSSQNETLLGARNKVRSNA--STKAGAKTGTRSSAQPQAVVSSQNEA
LLGARDKG----------------------------------------LSGSQVGATVDN
KMYARPV--AGAVPTSETASGV------GAQPNMHDYYWNGIGVEDWIAAERWIKFRFQT
MDGDWENTVSWTDDENAASVGPWSGA-NEK--TGIVSSWAVAC----DENSIKSWTGART
ENEVALGSWVGAG-DQASGALWAGAQAT-------------------DATGGSWTGAENQ
ISAGSWVVSGNQAIAGPWAVSQVSDGSWPAVQASGVSWVVDQATG-TWTV--------AD
NQAGAVSWTGA--------------------------GNIVSIGYWTGAVDQTNA-VSWT
G------------TGDQAGGEVKPRFEDQAGEKGTWAGAGVQTSGESRLGPEDQANGRSW
TETADQASAASRLGTVDPSGGASWAGTGDQAGAVSTAGS---------------------
---------------ADQSVGGSKPGFENQTSGEG-SWTGTVGQASGGSKSVPEDQSAGR
SWADSGNQLSGGFLANG--------------------------------DAGGCWA-GSG
DQSGGESRMGPRDQSNGESWPGTGDQTSG------------WY-------------CTYT
G---NQTIGGGSWAGASGQDVGGSKPVQVNQTTSGSWLVTGTQISGVSWTGD----QVGG
CSKPGFEDQAVGGGFWAGAGDQATGGSRPAVSEDQ-SSGG--------------------
-------------------------------------------------VSWGGAG---S
QASGGSWVGPV--DQ--------------------------TSGGESWPGSRSSNE----
---ASG------------------------------------------------------
-------------------------------GSRLDTQDQASGRFLVSAEVEANEGFWFG
PGSEAFIGSWCWTEE-ATILPIADLKDEASVESTSGTKEEATTSSGLGDEKKTSTEETAL
T--------------------GTCVGGEAKAGAEAEAGAGP--------EAGAETEVEAK
ARAETEIEAKAGAETEVEAKA-----EAEAKAE--------AEAGAETEVEAETGAETEV
E------------AK----AR--------------------AETEVEVEAEAGA------
ETEVE----------------------------------------VEAEAGAETE-----
--------------------VEVEAEAGAE-----------TEVEVEAEAGAETEVEVEA
EAGAETEVEV----------EAEAGAETEVEVE--AEAGAETEVE------VE-------
-----AEAEAETEVEVEAEAG-----AET----------------------RAEAGAA-A
AAAADSETGTEAVAVAE----------AVAETS-MEIWPWDGDAATKGSRHEAEAEAG--
------------------------A--------------------------------G--
VVAE-----------------------------------AGAGAGAGTRMGFWFWNEDST
TK--GARLGAEAGVGV-----------------------------VAEGGAEARMEFWSW
EGDA------------------------ASKGSRLGAEAEAGL-----------------
---GSWTFAADINDDDDE-EEEELSRESSP-GI-EEIS----------------------
-LRNLFGADSEDNNDLRST--------NEKD--ANSESGTGDKV-STKDKFDA-------
-ADGVDIRSWFCTGNENRCED-ESTSQVKAKKTTE-P----------RGIYPSM-VPGAG
MGVW----DGTIICSESK--LL------------KQ----SSFPGEE----G-----FR-
KQ-V-----------------------------------NT------------GDKVHSC
NCRCRR------DVNLDPQDLEKLICMIEMTEDASVHEIATNALYNSSDYPFPQ------
----------EIDRNIGGISVIQSLLGNPYPTV------RQ-KALNALNNL-SVAAENHR
KVKTYLSQVCEDTVTCPLNSNVQVAGLRLIKHLTITSEYQHMVTNYISEF-LRLLAMGSG
E-TK-DHVLGMLVNFSKNPSMTKDLLIAN---APTALINIFSKKETK----------ENI
LNALLLFENINRHFKKRAKTYPQ--------DR-FSK--SSLY-FLFQRPKACAKKLRAL
AADCSDPEVKEKVEVLINKL----------------------------------------
-------------------------------------------

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-----------------------MAGSGTEARARQKAEAGLKEG--------ISGP----
------AAARVSGETQAKAVA-----EAKLKTESV----TQAKAGDGAMARPHTVTYTVA
--MAVAREESRM------------------------------------------------
------------------------------------------------------------
-----------EDTTKTRVVVETKAKPLA-EHSIVPQTKSKAMPMSRV--SAVTESEVKI
V-----------------------------------------------------------
-------AVREANIRSYTKSH-----DKASTGSRPDR-----------------------
--------REEA------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------SIGM-----------------------------KSSDEDEENICSWFW
TGEE------------------------PSVGSWFWPEEETSPQV---------------
-----YKPLPK---------------------I-QEKP----------------------
------------------------------------------------------------
----------------------KPTPK------------------------PMLTIKQKA
-IAW----SRA--RYIVLVPIE------------GG--ERS-LPP---------EGNWTL
VETLIET--------PLGIRPLTKIPPYHGPYFQTLAE------IKKQIKQREKYGPNPK
ACRCKS-----HAFSLEPKEFDKLVALLKLTKDPFIHQIATMIMGISPAYPFTQ------
----------DIIHDVGITVMIENLVNNPDVKE------HP-RALGMVDDS-SESSKEPK
AEESYIQQVCKDIVSCPLNSPVQLAGLKLLGHLSVKFEDHYVITGYIPDF-LALLNKGSV
K-TK-FYVLKVFLCLSKNRANTRELVSAK---VLSSLVAPFNKNESK----------ANI
LNIIEIFENINFQFKTKAKLFTK--------EK-FTK--SELI-SIFQEAKQFGQKLQDL
A-EHSDPEVRDKVIRLILKL----------------------------------------
-------------------------------------------

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---------------------------------MGRTREAGCVAAG----------VVIG
AGACYCVYRLT--WGRDE-NEKIWD----DDDEDDEE--ESSDI----------------
---------------------------VETRIENG------KGAKANAGMGSEARLQGDS
-----------------------------KV------------KAEVGMVLESGSDVKAE
VHL----------------G--------PQSGGGLE---AKA------------------
-----------------KALFST-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------L----------------------------------
----------------KEQASAKAGRGARLSTIS--------------------------
---------------------------------------------GNRTLAPSLPCPGGR
GG---------GCHPTRSGARA---------------------------------GSRAS
GKTKGRTRGKSTRTPA-T---------------------------AW----PVRRGKFNF
PYKID--------DILGAPDLQKVLNILERSNDPFIQEIALVTLGNNAAYSFNQ------
----------NAIRELGGLPIIAKLIKTKDLII------RE-KAYNALNNL-SVNAENQG
KIKTYISQVCDDTMICRLDSAVQMAGLRLLTNMTVTNHYQHLLSYSFPDF-FALLFLGNY
F-TK-IQIMKLIINFTENPAMTRELVSCK---VPSELISLFNKEWDR----------EIL
LNILTLFENINDNIKSEGLASS---------KKEFSR--SSLFF-LFKESGVCIKKIKAL
A-NHNDLVVKVKVLKVLTKL----------------------------------------
-------------------------------------------

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-------------------------------------------------------MGFRP
GD---------GAAAAAAASAN------------GGQAFLAEIPES-----EEGESGWTD
TESDSDSEPEVQQRGKG----------------------------KR----TIPMHKRPF
PYEID--------EILGVRDLRKVLALLQKSDDPFIQQVALLTLSNNANYSCNQ------
----------ETIRKLGGLPIIANMINKTDPHI------KE-KALMAMNNL-SENYENQG
RLQVYMNKVMDDIMASNLNSAVQVVGLKFLTNMTITNDYQHLLVNSIANF-FRLLSQGGG
K-IK-IEILKILSNFAENPDMLKKLLGTQ---VPSSFSSLYNSYVES----------EIL
INALTLFEIIFDNLRAEVFN-----------YREFNK--GSLFY-LCTTSGVCVKKIRAL
A-NHHDLLVKVKVIKLVNKF----------------------------------------
-------------------------------------------

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-----------------------------------GPGAGLKAG--------IRGP----
------ANTKAKAKIQAKAVA-----E-----------------------D--TVTYTEA
--MAMTRQVSKM------------------------------------------------
------------------------------------------------------------
-----------ESKAKTRVMAETKATPLT-EPSVVSQTKSKAMPMSKL--SAVTQCKVKA
G-----------------------------------------------------------
-------ARSEASIGS-----------KDSPGSMSQR-----------------------
--------RSEAS-----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------VKL-----------------------------KFSDEDEENVCSWFW
TGEE------------------------PSVGSWFWPKEDNPFQV---------------
-----YKPPAK---------------------I-QEMP----------------------
------------------------------------------------------------
----------------------KPTPK------------------------PELTIKQKV
-KAW----SRA--RFCVLVPVD------------GG--EQS-LPP---------GGNWTL
VDTLIET--------PLGIRPLTKIPPWNGPYFQTLAE------LKNQVKYREKYRPNPK
TCRCKS-----YVFTLEPKEFDKLVALLKLTTDPFIHEIATMIMGISPAYPFTQ------
----------DIIHDVGITVMIENLVNNPNVKE------HP-RTLNMVDDN-AESSGEPQ
-RELYINQVCRDIISYPLNSTMQLEGLKLLVQLSVNFEYHHIIVNYIPDF-LTLLNKGSV
K-TK-FYVLKVCLHLSKNQANTRELISAK---VLSSLVAPFNKNESK----------ANI
LNIIEIFENINFQFKKKVKLFTK--------EE-FTK--YELI-SIFQEAKEFGQKLQDL
A-EHSDPEVRDKVIRLILKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
---------------------------------------MTGTKN--KTRAQAKTEKK-P
VTQAKAGAEREATGV------VRPV---------------------AKTRAKAKAKTGSK
-----TDAV---------------------------------------------------
------AEMKAV-------------SKNKVVAEVKEGALSEPKTLGRAM-----------
-----GDF----------------------------SPKAGNESTSSTCNNEAGIDAWFW
AGEE------------------------ATINSWFWNGEEAGN-SSST------------
---------KNDKP--------EIGAQVCA----E-------------------------
------------ELEPAAGADCKPRSGAEE------------------------------
EEEENVIGNWFWEGDDTSFDP-NPKPVSRIVKPQP---VYEINEKNRPKDWSEVTIWPNA
PAVTP---AVLGFRSQAPSEASPPS----YIVLASAEENACSLPGA------TACRPSRN
TRSCSQPIPECRFDSDPCI--------------------QTIDEIRRQIRIREVNGIKPF
ACPCKM------ECYMDSEEFEKLVSLLKSTTDPLIHKIARIAMGVHNVHPFAQ------
----------EFINEVGVVTLIESLLSFPSPEM-------RKKTVITL-NP-PSGDERQR
KIELHVKHMCKETVSFPLNSPGQQSGLKILGQLTTDFVHHYIVANYFSEL-FHLLSSGNC
K-TR-NLVLKLLLNMSENPTAARDMINMK---ALAALKLIFNQKEAK----------ANL
VSGVAIFINIKEHIRKGSIVVVD----------HLSY--STLM-AIFREVKGIIETM---
------------------------------------------------------------
-------------------------------------------

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-----------------------MINSKATENAREEVGDGLKAA--------ISSP----
------DNARVRAKAQSIAVV-----EAEPKAELM----TQAKFGDGIMAMTQPMTYTEP
--VTRIREVNKM------------------------------------------------
------------------------------------------------------------
-----------EHMTDTRVVVETQTKLFA-QPAIVPQTKSEAVLVSRL--NAITKPTVRV
V-----------------------------------------------------------
-------SGSEENVRSCAKAD-----DKANIVSRYEI-----------------------
--------KEEASIKSM----------AG-------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------NKAGFGI-----------------------------KSTDEDEENVCSWFW
TGEE------------------------PSVGSWFWPEEENSLQT---------------
-----YEAPPK---------------------I-QETP----------------------
------------------------------------------------------------
----------------------TPTPTPMPTPTH----------------KLKLTVKQKA
-TAW----SRD--RYIVLVPIE------------ED--EQP-LPP---------EGNWTL
VTTLIET--------PLGIRPLTKIPLYNGPYLQTLAE------IKKQIRQREKYGPNPR
ACYCKS-----RCFSLEPKEFDKLVALLKLTKDPFIHEIATMTMGISPAYPFTQ------
----------GIIHDVGITVMIENLVNNSNVKE------DS-TACNVVDNS-AESSAEPK
VGESCIPQMCKDIISYPLNSTVQLAGLKLLVPLSVKFKNHQMILSYIPDM-LTLLNKGSV
K-IK-FYALKVFLCLSKNQANTRKLISAE---VLSSLVALFNKNESK----------ANI
FNIIEIFENINFQFKRGSKLFTK--------EK-FTK--SELI-SIFQEAKVFGQKLQDL
A-EHSDSESSTSL-----------------------------------------------
-------------------------------------------

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VVRPKV--------------------------RTQAQAMPGARPKTESKSVAGARPKTES
------KAMA------------GARPKT----------------------------ESQA
MAGARPKT----------------------------ESQAIAGARPKTE------ARAVG
GARPKT--EAKAIPGTRPKDEA--------------Q--------------AWAQTEFG-
-----AEAMSQTESVSQNNAVAWPLVSSES--GSVAKPMGLPVDRELVGVETETFPGSQ-
-VQTGIQPWFGSG-EETN------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---TGSWCYPRPRAR-EEASNESGFWSADETSTMSSFWAGEEASIRSWPREEA---NTRS
RHRAKHQ-----P--NPRSKLRSKQDPYIDS-WSGSE-----------------------
-EESGNPFCLWAGENTNNLF----------------------------------------
---------------------RPRVRDEPNIRSKLRTKREDF--FESESE------DEYY
KESWFLPGEEA---------NSR-----FRPRDKEEPNTILKSR----------------
AQ----NDVNNSDRAKQESRF-----EEDVIIGSWFWAEKEA------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------GM
EAG------ATAICESEPGAE-----EGAI------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------GGSLFWTEDKS
NLGA--------------------------------------------------------
-----------------------------------------------VAKEEARPES---
------------------------------------------------------------
------------------------------------------------------------
-EEEAIFGSWFWDRDEACFDL-NPRPVYKAAPRFRDSAEEEVNVSSRPQTWDEVTVEFKP
-GLC----HGVGFPSPSPFRIPEEAVASVYSEMFEGKPKIVEVTPEG----E--DQESLL
QPDQ--PDPEFSFHYDASX--------------------XXXXXXXXXXXXXXXXXXXXX
XXXXXX-----XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXR------
----------DFIRDSGV-SLIETLLNYPSSRV------RT-SFLENMIHM-APPYPNLN
MIETFVCQVCEETLAHSMGSPEQLLGLRMLRHLTTTTDYHTLVANYMSGF-LSLLTTGNA
R-TK-FHVLKMLLNLSENPMVAKKLFSAK---ALSIFVGLFNIEETN----------DNI
QIVIKMFQNISNIIKSGTMSLID---------DDFSL--EPLI-SAFHEFEKLAEELQVQ
LDNQNDPEGQKS------------------------------------------------
-------------------------------------------

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---------------------------------------MTGSKN--KARAQAKLEKR-A
SAQAKAAAEREAANA------GRGA---------------------GKNRDKGKGKAGSK
-----TDAV---------------------------------------------------
------AEAKAG-------------SKSKVVAETKEGARPESKAVAKGT-----------
-----SDF----------------------------NHKAENKYARSARKDKPSSDSWFW
AGED------------------------SGINSWFWKGEEVSN-NSVA------------
---------KCENK-------PSTSIQARV----E-------------------------
------------E--HTPRTSHKSRSGAEE------------------------------
EEEENVIGNWFWEGDDTGFDS-DPKPVFKIVKPQP---VDEINEKDRPKDWSEVTIWPKA
PAVTP---AVLGYRSQDSSEGRPSS----YIVLASNEEETST------------T-CTKN
TRSSLQPIPEYPFGSDPCI--------------------QTLDEIRQQIKIREENGIKPF
ACPCKM------ECYLDSPEFEKLVNILKSTTDPLIHKIAQIAMGIHKVHPFAQ------
----------EFINEVGVVTLIESLLSFSSPEV------SIKKAVITL-N--SSGDDRQQ
MVEFHVKHMCKETVSFPLNSPGQQSGLKIIGQLTTESVHHYIVVSYFSEL-FHLLSQGNR
K-TR-NLVLKVFLNMSENPKAARDMINMK---ALAALKLIFNQKEAK----------ANL
VSAVAIFINIKEHIRKGSIVVVD----------HLSY--NTLT-AIFREVKGIIERM---
------------------------------------------------------------
-------------------------------------------

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---------------------------------MGRTREAGCVAAG----------MVIG
AGACYCVYRLT--WRKDE-NEKIWD----DDEEFSDT--S--------------------
----------------------------EIGVETE------KGAKNNVGVGVGAKPQC--
---------------------------DTEA------------KAEVRLGLESGPGIKQG
SHC----------------G--------SQSRGGLE---AKA------------------
-----------------KALF---------------------------------------
-----------T------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------IL----------------------------------
----------------KEQASAKVGKGARIGNIS--------------------------
---------------------------------------------GSRTLAPSLPCPGVR
GG---------GCHPAKSGARA---------------------------------GRKAS
GKSKGKARNKSTRALP-T---------------------------TW----PVRRGKFNF
PYKID--------DILSTPDLQKVLNILERTNDPFIQEVALVTLGNNAAYSFNQ------
----------NAIRELGGVPVIAKLIKTKDPII------RE-KTYNALNNL-SVNAENQG
KIKTYISQVCDDTVICRLDSAVQMAGLRLLTNMTVTNHYQHLLSYSFPDF-FALLFLGNH
F-TK-IQIMKLIINFTENPAMTRELVSCK---VPSELISLFNKEWDR----------EIL
LNILTLFENINDNIKTEGLASS---------RKEFSR--SSLFF-LFKESGVCVKKIRAL
A-NHNDLVVKVKVLKVLTKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
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---------------------------------------MFLGQPKNAGFPFSW------
----------DLSSQLASLSLAGNIIPIPDSAI------EEGKALWAADNLWNASVENQG
QMKMYIHEVCRETVSLCCNSFLQQAGFHVLVSMAVINN---MLAKSISDSKFPLLSGGSE
C-AE-GQVLKPLMGLSEKPVLVGEWLGSQ---MLPSFLSLSIRNTHR----------QLL
PDTLAS------------------------------------------------------
------------------------------------------------------------
-------------------------------------------

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---------------------------------MSRVRDAGCVAAG----------IVIG
ASAWYCVYKYT--RRRNQ-MKKRLA----KPKTRA--LAGTGARARSGLRAGFTIDLGPG
FHPPTPVCTGAEDK-AQDEASALYINAAEVVAPAA------FSAEAQSGAGSQALETEGA
--WFGPQS-ESVVGAEVASTMAPPQGEAEAL------------ITAEVPTMAGAPKMTDT
PGT----------------T--------EVPRMPAVPPGTPAPTEA-AA-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------PTEAAEAPV------------LAALS---------
------------------------------------------------------------
------------------------------------------------------------
------------------EAV-----------------E-AL------------------
----------------------GTSGSPK-------------------------------
-----------TVA-----ATKKATPGSQTGAIPKAGS--ATGA---VPKGGA-------
-----------KGGTRSRTGG-K----GKGK-------------KNSKVEVDQLGLGFRP
GD---------GAAAAAAASAN------------GGQAFLAEVPDS-----EEGESGWTD
TESESDSEPETQQRGRG----------------------------RR----PVPMQKRPF
PYDID--------EILGVRDLRKVLALLQKSDDPFIQQVALLTLSNNANYSCNQ------
----------DTIRKLGGLPIIANMINKTDPHI------KE-KALMAMNNL-SENYENQG
RLQVYMNKVMDDIMASNLNSAVQVVGLKFLTNMTITNDYQHLLVNSIANF-FRLLSQGGG
K-IK-IEILKILSNFAENPDMLKKLLSTQ---VPSSFSSLYNSYVES----------EIL
INALTLFEIIYDNLRAEVFN-----------YREFNK--GSLFY-LCTTSGVCVKKIRAL
A-DHHDLLVKVKVIKLVDKF----------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
-------MTGAEIEPSSQAKPEKKAGEEV--------AV-----------GAERENEVPL
VVRPKV--------------------------RAQ--GTTGARPKTETKSVPGARPKTEA
------QTMSGA------------RPKT----------------------------EAQA
MTGARPKT----------------------------ETQAMAGARPKTD------GRAVR
GTRPKA--ETKAIPGTRPKNEV--------------H--------------AWAQTDFA-
-----AEAMSQAEGVSQTNAVAWPLVSTES--GSVSKSKGLSMDRELSNMDSETFPGSQ-
-GQKGIQSWFGPG-DETN------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---MGSWCYPRPRAR-EEASNESGFWSADETSTVSSFWAGEETSIRSWPREEA---NTRS
RHRAKHQ-----T--NPRSRPGSKQEPYVDS-WSGSE-----------------------
-DEAGNPFGFWAGENTNNLF----------------------------------------
---------------------RPRVREEANFRPKLRTKREDC--FESESE------DEFY
KESWFMPGEEA---------NSR-----FRHRAKEEPNTILKPR----------------
AR----KDVRNGDRVKQEPRF-----EEEVLIGSWFWAEKES------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------NL
EAG------ASATCESEPGAE-----EGAI------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------GGSLFWAEEKS
SLGA--------------------------------------------------------
-----------------------------------------------VAREEARPES---
------------------------------------------------------------
------------------------------------------------------------
-EEEAVFGSWFWDRDEACFDL-NPNPVYKASNRFRDSAEEELNTSSRPQTWDEVTVEFKP
-GPC----HGVGFPSTNPFRIPEEAS-----EIFEAKPKQAELSPEG----E--EQESAL
------PDSEFPFQYDPSY--------------------RSVQEIREHLRAKESAEAENW
SCNCIQ-----CELKIGSVEFEELLLLMDKIRDPFIHEISKIAMGMRSASQFTR------
----------DFIRDSGVVSLIETLLNYPSSRV------RT-SFLENMIHM-APPYPNLN
MIETFICQVCEETLAHGVNSLEQLTGIRMLRHLTVTTDYHTLIANYMSGF-LSLLTTANA
G-TK-FHVLKMLLNLSENPAVAKKLFSAK---ALSIFVGLFNIEETN----------ENI
QIVIKMFHNISNIIKKGRMSLID---------DDFNL--EPLI-SAFREFEELAKQLQAQ
IDNQKDPEVGQQS-----------------------------------------------
-------------------------------------------

------------------------------------------------------------
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---------------------------------------MTGAKK--ESRNKAKTQKR-A
GVQAE--AKRESTGL------VRPV---------------------VKTQDKATAKAGSQ
-----ADAAM--------------------------------------------------
------TTMKAR-------------SKNRIVTEIKERALADFSPKAEDEATR---VPGMS
SV---AEV----------------------------NAES-----RSTCKDKAGIDTWFW
AEEE------------------------ANVGSWFWNGEETSN-PSSA------------
---------KDEGK-------AGIGPPTCA----E-------------------------
------------KLEPVAGASCKATPGTEE------------------------------
EEEENVIGNWFWDGDETSFDP-NPRPVSRIVRPQP---VDEINEKNRPKDWSEVTIWPKA
PAVTP---AVLGFRSHVPFETKPPS----YIVLASAEENTPSLPVE-----T--TCPSRS
TTSSSQPVPEYPFGSGPCI--------------------QTIEEIRRQIRIREVNGIKPF
ACPCKM------ECYMDSEEFEKLVNLLKSTTDPLIHKIAQIAMGIINVHPFAQ------
----------EFINEVGVVTLIESLLSFPSSEI-------RKKAVITL-NP-PSGDERQR
KIELHVKHMCKETMSFPLNSPGQQSGLKILGQLTTDSNHHHIVANCFAEL-FHLLSLGNR
K-TR-NLVLKVLLNMSENPAAARDMINTK---ALAALKLIFNQKEAK----------ANL
VSAVAIFINIKEHIRKGSIVVVD----------HVSY--NTLM-AIFREVKVIIERM---
------------------------------------------------------------
-------------------------------------------

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-------MTGAEIEPAAQAKPEKKAGEEVG--------G-----------GAERENEVPL
VVRPKV--------------------------RTQAQVMPGARPKTETKSMPGARPKTES
------QAVAGARPKTESQAVAGARPKT----------------------------ESQA
NAGARPKT----------------------------ESQANAGARPKAE------ARAIG
GARPKT--EAKAIPGARPKDEA--------------Q--------------AWAQTEFG-
-----AEAMSQTEGLTQTNAVAWPLVSTES--GSVAKPLVLPMDRELVSVDTETFPGPQ-
-VQTGIQPWFGSG-EEAN------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---TGSWCYPRPRAR-EEASNESGFWSADETSTMSSFWAGEEASIRSWPREEA---NTRS
RHRAKHQ-----P--NPRSRPRSKQDPYIDS-WSGSE-----------------------
-EESGNPFCLWAGENTNNLF----------------------------------------
---------------------RPRVKDEANMGSKLRKKREDF--FESESE------DEYY
KESWFLPGEEG---------NNR-----FRTRDKEEPNTILKPR----------------
AQ----KDVNNSGRVKQEPRF-----EEEVIIGSWFWAEKEA------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------GM
EAG------ASAICESTPGAE-----EGAI------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------GGSLFWTEEKS
SLGA--------------------------------------------------------
-----------------------------------------------VAREEPRPES---
------------------------------------------------------------
------------------------------------------------------------
-EEEAIFGSWFWDRDEACFDL-NPSPVYKANSRFRDSAEEELKASSRPQTWEEVTVEFKP
-GFC----HGVGFPSPSSFRIPEEA-ASVFSEMFEGKPKNAEFTPEG----E--DQESLL
QSEQ--VEPEFPFQYDPSY--------------------RSVREIREHLKARESAEAESW
SCSCIQ-----CELKIGTEEFEELLLLMDKIRDPFIHEISKIAMGMRSASQFTR------
----------DFIRDSGVVSLIETLLNYPSSRV------RT-SFLENMIHM-APPYPNLN
MIETFICQVCEETLAHSVGSPEQLLGLRMLRHLTITTDYHTLVANYMSGF-LSLLTTGNA
R-TK-FHVLKMLLNLSENAIVAKKLFSAK---ALSIFVGLFNIEETN----------DNI
QIVIKMFQNISNIIKNGTMSLID---------DDFNL--EPLI-SAFHEFEKLAKELQVQ
IDNQNDPEVGQQS-----------------------------------------------
-------------------------------------------

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------------------------------------------MPMARV--SAVTKYEVKA
R-----------------------------------------------------------
-------AGSEANIRSFAKAD-----DKADIESRPQR-----------------------
--------KREDGIKFR----------AG-------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------AEDRAGIVT-----------------------------ESIDKDEENVCSWFW
TGEE------------------------PSVGSWFWPEEETPSQV---------------
-----YKPPPK---------------------I-QEKA----------------------
------------------------------------------------------------
----------------------KPI--PK----------------------PELTIKQKA
-AAW----SRA--RYSVLVPIE------------GG--EPS-LPP---------EGNWTL
VETLIET--------PLGIRPLTKIPPYNGPYFQTLAE------IKKQVKYREKYGPNPR
ACRCKS-----RDFSLEPKEFDKLVALLKLTKDPFIHEIATMIMGISPAYPFTQ------
----------DIIHDVGITVMIENLVNNPNVTE------HP-RALNMVDDN-SESSEEPK
PAESYIRQVCKDIISYPLNSPVQLAGLKLLVHLSVKFEDHHIIANYIPDF-LTLLNKGSV
K-TK-FYVLKVFLRLSKNQANTRELISAK---VLSSLVAPFNKNESK----------ANI
LNIIEIFENINFQFKKKVKLFTK--------EE-FTK--SELI-SIFQEAKEFGQKLQDL
A-DHSDPEVRDKVIRLILKL----------------------------------------
-------------------------------------------

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-----------------------MVDSGTEARARGKAESGLQDG--------ISGP----
------AAARVNGKTQAKAVA-----EAELKTESV----TQAKAGDGAMTRTHTVTYREA
--MAVTREVIKV------------------------------------------------
------------------------------------------------------------
-----------EDTTKTRVMVETKTKPLA-ECSIVPQTKSKAMPVSRV--STVTKSEVKV
V-----------------------------------------------------------
-------AVIEANIRSYAKSH-----DKASTGSRPDR-----------------------
--------REEA------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------SIGM-----------------------------KSSDEDEENICSWFW
TGEE------------------------PSVGSWFWPEEETSLQV---------------
-----YKPLPK---------------------I-QEKP----------------------
------------------------------------------------------------
----------------------KPTHK------------------------PTLTIKQKV
-IAW----SRA--RYIVLVPVE------------GG--EQS-LPP---------EGNWTL
VETLIET--------PLGIRPLTKIPPYHGPYYQTLAE------IKKQIRQREKYGPNPK
ACHCKS-----RGFSLEPKEFDKLVALLKLTKDPFIHEIATMIMGISPAYPFTQ------
----------DIIHDVGITVMIENLVNDPNVKE------HP-GALSMVDDS-SESSEEPK
SGESYIHQVCKGIISCPLNSPVQLAGLKLLGHLSIKFEDHYVITSYIPDF-LTLLNKGSV
K-TK-FYVLKVFSCLSKNHANTRELISAK---VLSSLVAPFNKNESK----------ANI
LNIIEIFENINFQFKTKAKLFTK--------EK-FTK--SELI-SIFQEAKQFGQKLQDL
A-EHSDPEVRDKVIRLILKL----------------------------------------
-------------------------------------------

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---------------------------------------MTGTKN--KTRAQSA------
-IQAKAGEEREATGV------VRPV---------------------AKSWAKAKDKPGSL
-----TDAV---------------------------------------------------
------AEMKAV-------------SKNKVVAEMKEGALSEPKALGKAI-----------
-----GDF----------------------------SPKARNESTSSTCENGA-----G-
--------------------------------------VDAGN-HSSA------------
---------KNDKP--------EIGAQVSA----E-------------------------
------------ELEPVAGASCKPRSGAEE------------------------------
EEEENVIGNWFWEGDGTSFNP-NPKPVSRIVKPQP------------------VTIWPKS
PA-------VTPAVS-QASEASPPS----YIVLGLAEEISYSWPVA-------AACPCRN
TCSCSQPVPE------------------------------------------EVNGIKPF
ACPCKM------ECYVDPEEFEKLVSLLKSTTDPLVHKRAQIAMVITLNPP---------
-----------------------------------------------------SGDERQH
KIELHVKHMCKDTMSFPLNSPGQQSELKILGQLTMDFVHHYIVASDFSEL-FHLPSSGKY
K-AR-NLVLKVILNMPENPTAARDTINMK---ALAASKLIFNHKEAK----------TNL
VSGVAVFINIKEHIRKGSIVVVD----------HLSY--NTLM-GIFREVKGIIETM---
------------------------------------------------------------
-------------------------------------------

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---------------------------------MGGARDVGWVAAG----------LVLG
AGACYCIYRLT--RGQRR-VGR---------GPRLRP--SP-------------------
------------------------------------------SAE---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------DLT
DGSYD--------EVLNAEQLQKLLYLLESTEDSVIIERALVTLGNNAAFSANQ------
----------AIIRELGGIPIVGDMISNPNHSI------KE-KALNALNNL-SVNVENQD
IIKIYINQVCEDVFSDPLNSAVQMAGLRLLTNMTVTNDHQHMLNSYITDF-FHVLLTGNG
N-TK-VQVLKLLLNLSENPAMAEGLFGAQ---VDSSFLSLYDSRVAK----------EIL
LRALTLFQNLNNCVKKDGHLVLRS-------TSTFHK--GSLFFLLYGE--ECAQKMRAL
A-NHPDVDVKEKVVIITPCF----------------------------------------
-------------------------------------------

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---------------------------------MGYVRKVGWVTAG----------LVIG
AGACYCIYRLT--RGRKQNKEK-MA----EGGTGDVD--DAG----------------DC
---------------------------------------------------------TGA
--RY-DWSDDD-------------------------------------------------
DDS----------------N--------D-------------------------------
------------------------------------------------------------
-SKSIVWYPPWAR-----------------------------------------------
------------------------------------IG----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------T--------------------------------
-----------EAGTRARARA---------------------------------------
------------------------------------------------------------
-------------RARAT---------------------------RA----RRAVQKRAS
PNSDD--------TILSPQELQKVLCLVEMSEKPYILEAALIALGNNAAYAFNR------
----------DIIRDLGGLPIVAKILNTRDPIV------KE-KALIVLNNL-SVNAENQR
RLKIYMNQVCDDTITSRLNSSVQLAGLRLLTNMTVTNEYQHMLANSISDF-FRLFSAGNE
E-TK-LQVLKLLLNLAENPAMTRELLRAQ---VPSSLGSLFNKKENK----------EVI
LKLLIVFENLNDNFKWEENEPT---------LNQFGE--GSLFF-FLKEFQVYADKVLGI
E-SHHDFLVKVKVGKFMSKLSEHMFPKIQE------------------------------
-------------------------------------------

------------------------------------------------------------
--------------------------------------------MGRVQDVGWATAGLVI
WAGTCYCIYRLTKGRYQSVS---RDGSRI-KTETV----------------------TET
RAM--TEPETGEGGEPVAEVDTKVPVLTH----------------------SE-------
TSLLVETMVMTDAVTFTEAT--GQAKEVTMKEAVTQTDVETEEVGKKEAVTQTK-SKAWA
V-----VKKEAMTQTKAEAPSLAEKETEINRVTVTQSEVLAVTK-------------ETG
IVAEATIRALEETVCVTRTQSETRLDVTVDTNENSNDMPLIVAGVDVKSYAQPQAVTIIQ
NDDMIGDEGDDQGNLK---------------------------NTSKAGSAVDKDTSAQP
HIVANILAEAMPGAKDDACDNTNDICEAE--ADLRTYIIQPETVATIQAEAMSGAT-TDD
GEDASDVFKAMTGAEITD-TNPQAVTSDHIEATPDANAKGKGNASATAKAGAKANTKTNL
QTDALPETEDKNRSDTNDMAKAEASVDVVSCA-QPDPVA--------------SDNANTI
SKEGTQT--------TAQSQGEALPNTKGKARGKAKAKCKAGAAADVKPCAQPQGGIKTQ
AEPLSDSKVDSKSDSNAVSKAGAKADQKACAQPQPVVNCQNEALPATKNKVKGNPNPMPK
AEAGTATAGSAQT-----------------------------------------------
------------------------------------------------------------
------------NVVTSSQGETTPGAKTKVKGNRNSVPKAGAGPDT--------------
--------------------------TGSAQNQTVASSHSEALPGAKNKVKSNPNVVPKA
EAGVGACPQSV-------------------------------------------------
------------------------------------------------------------
--------------------------AVSQGTALTGTKAKVKGNSNAVSKPDAGAGTM--
------------------------------------------------------------
----------------------------------------------------------GS
AK--AVTSSQGETLPGSKSKVKGNSNAVPKAD-----AGATTTDSVQPQ------AEALL
GARNKVRGNSNSVPKAESGASTILA-----LASSQAEALLGARNKVRGN--SNTVPKAEA
GSGARGSAQSQAVVSSQNETLLGARNKIRANA--STKSGAKTGTRGSAQPQAVVSSQSEA
LLGARDKG----------------------------------------LSSSQVEATADN
KTHARPV--AGAVPTSESVSGA------GAQSNMHDYYWNGIGVEDWIAAERWIKFRFQT
IDGDWENSVTWAEDENGAAVGPWSGA-NDK--TGIVSSWAVAC----DEASIKSWTGART
ENEVALGSWVGAG-DQTSGALWAGAQAADGTWVAD------------KTGGASWTGAENQ
LSAGSWVVSGNQAITGPWAVSQVSDGSWPAVQASGVSWVVDQATG-TWTV--------AD
NQAGAMSWAGA--------------------------GNIVSIGYWTGAVDQTNA-VAWT
GT------------AEQVGGEVKPRYEDQASEKGTWAGAAVQTSGDSRLGPEAQSSGRAW
AETADQASAASRLATVDPSSGVSWPVTGAQAGGVSTSGSADQSSSGSWTGTRNL------
------TGERSWTGTGDQSNGGAKPGFENQTGAEG-SWTGTISQASGGSKSVPGDQSAGR
SWTNSGDQLSGGFLVGPLDQASGNSQPGS----GDLVASG-----VNPSSGGGCWA-GSG
DQSGGESRMGTRGQTNGQSWPGTGDQTGG------------WY-------------CTYT
P---TQAIGGASWG-ATAQDIGVSKPVQVNQSSSGAWLGSGTQVGGVSWTGD----QVGG
CPKPGFEDQAIGGGFWAAAGDQSTGGSRPAVSED-QSSGGVSWGGAGAHVI---------
------------------------------------GGNRTCPTDQASGASWAGIG---S
QVSGGSWVGPV--DQ-TSGCSKSGFEDQ-TCGGGSWAGAVDQTSGESWPGSRASNE----
---ASGG-----S--KL-----------------DTQ-----------------------
--------------------------E------------QTSGRFLVSAEVEANEGFWFG
PGSEAFIGSWCWTEE-ATILPIANMNDETSGESTSGTKEETSASSGLEDE------KKTS
TESWTRAEETA--------LAGTCVGGEPENVAGAEAEVETEAKDTAEAEAGAGPE--AG
AGPE------AGAGTE--AGA-----GPE------------AGAGPEAGAGPEAG-----
------------------------------------------------------------
-------------------------------------------------------AGPEA
GAGTE-------DGAGPEAGAEAEAGAEAE---------------------------AEV
EAEVEAEVEAEVEAEVEAEAEAEAEVEAE------AEAEAEAEAE--AEAEVGVETR--A
EAGAAAATGAEAGPRVEAEAG-----AEAGTGFWSWDGD--AAT--KGSRLGAEA-----
--EAEVEAGAGGGAEAE----------AETENS-MGFWFWDGDATTKGSKLGAEAG----
------------------------------------------------------------
------------------------------------------------------------
---------------A-----------------------------EAEAVTETSMGFWFW
EGDG------------------------AAKGSKLGVEAEAGLGS---------------
-----WTFSTDVNDDDDD--DEELSRESSP-GI-EE-------ISLRNL-----------
-----FGAESEDNNDLRST--------NEKD--TNSESGTGDK-DSTKDKFDA-------
-ADGVDIRSWFCTGNENRCED-ESTSQVKAKKSTE-P----------RGIYPPM-VPGAG
MGVW----DGTIVCSESK--LL------------HQ----TSFPGED----G-----FR-
KQ-A-----------------------------------NT------------G--AHSC
NCRCRR------EVNLDPQDLEKLICMIEMTEDPSVHEIATNALYNSADYPYPQ------
----------EIDRNIGGISVIQSLLSNPHPTV------RQ-KALNALNNI-SVAAENHR
KVKTYLSQVCEDTVTYPLNSNVQVAGLRLIRHLTITSEYQHMVTNYISEF-LRLLAMGSG
E-TK-DHVLGMLVNFSKNPSMTKDLLIAN---APTALINIFSKKETK----------ENI
LNALLLFENINHHFKKRAKTYPQ--------DR-FSK--SSLY-FLFQRPKACAKKLRAL
AADCSDPEVKERVEVLINKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
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----------------------------------------------------------SS
PPVST--------PTMDVDALQKLIHLLQATDDPLIQEQALITLSNSAAFSVNQ------
----------DIIRNLDGLSVIGGMLSNCTPKV------KE-KALNALNNL-CMNIKNQE
EIQVFITQVCRTVESAPMNSDVQLAGLRLLTNMSVTSDYHQKMINSIPCF-LRLLSEGTE
R-TQ-IQVLKVLVNLSANPAMTRHLLRAQ----VPSLVLLFNKCTNK----------DIL
VRALTFAANLKKNMNDEEGTMI----------EEYSE--NSIFFTLCKDSAPFAQRLASL
L-HHPDTEVKEQVKKSLTRAVSYIFL------------KIFQ------------------
-------------------------------------------

------------------------------------------------------------
--------------------------------------------MGRVQDVGWATAGLVI
WAGTCYCIYRLTKGRTQSVSGHARNGSRI-ETETVVG----EQNQTLATSEAMAGREAET
RVK--TEPETGEGGEPVAEVDSKVPVLVRPSVNCQ----AKTMLEEEIETQCE-------
TSSLVETMVMTEAVTLTEST--SQAKEVTMKEAVTQTDAEAEAVGKKEAVTQTK-AKAWA
MAGRAEVKKEAMTQTKAEARILAEKETEINRVTVTQSEVLAVTKE----VVKIGTMNETG
IVAEAMIRPLEETVSVTRTQSEARLDATVDTKENLNDMSVVVTGVDTKSYAQSQAVAIIQ
NDDMAGAEAD-KEDLK---------------------------NMSKAGSGVDTKASGQP
HIAANSLAEAVPGAKNDACDTAKDICEAE--ADIRTCLIQPETVAKIETEATSDAV-MDG
GKDAN--VKAMTDANVTD-TQPQAVTSDQTEAMPDAKVKGKGNASAMAKAGAKANTKTSL
QTDALPDTGDKNRSDNNVTAKAEAGIDMVSCT-QTEPAANVQGDDLPDGKIKAKDNANTT
SKEGAQA--------TAQSQGEALPNTKGKARGKAKAKCKAAAGTDTKTCAQPQAGTKTQ
AEALSDSKVDSKSDSNAVSKAGAKSDQKACGQPQPVVNCQNEALPGTKNKVKGNPNPMPK
TEAGTATTSSAQT-----------------------------------------------
------------------------------------------------------------
------------NVT-SSQGETTPGAKNKAKGNRNSVPKAGAGPDM--------------
--------------------------TGSAQSQTVANSHSEALPGAKNKVKSNPNVVPKA
EAGVGACPQSV-------------------------------------------------
------------------------------------------------------------
--------------------------AASQGTALTGTKTKVKGNSTTVSKPDAGAGTL--
------------------------------------------------------------
----------------------------------------------------------GS
AHAKTAANSQGETLPGSKNKVKGNSNAVPKAE-----AGAGTTDSNQPQ------AEALL
GARNKVRGNSSSVPKAESGASTILA-----LASSQAEALLGARNKVRGS--SNAVPKAEA
GVGARGSAQSQAVISSQNEALLGARNKIRSNA--GTKSGARTGTRSSAQPQAVVSSQNEA
LLGARDKG----------------------------------------LSSSQVEATVDN
RVYAKPM--VGAVPTSEMVTVA------GAQTNVHDYYWNGIGVEDWIAAERWIKFRFQT
IDGDWENSVSWTEDESGASIGPWTGAANDK--AGIVSSWAVAC----DESSIKSWTGARP
ENEVALGSWVSAG-DQATGAIWAGAQTSDGTWVAD------------KASGSSWTGAD-Q
ISAGSWVVSGNQAIAGPWAVSQVTDGSWPAVQASGVSWVVDQATG-TWTV--------AE
NQTGAVSWAGA--------------------------GNIVSIGYWTGAVDQTNA-VSWT
GT------------TDQVGVEAKPRFEDQASEKGSWVVAGVQTSGESRLGPEDQSSGRSW
TETVDQASAASRLGTVDPAGGTSWVGTGDQVGGVSTSGSADQSSSGSWAGTRNL------
------AGERSWTGTGDQSDGAAKPGFENQTSDEG-SWAGTIGQPSGGSKS--EAQSAGR
SWADSGDQLSGGFLVGPLDQANGESQPVS----GELAASG-----VDQTSGGGCWT-GSG
DQSGGESRLGPRDQSNGESWPGTGDQTGG------------WY-------------CTYT
G---TQTIGGGSWVGASGQDVGGPKPVHMNQATGGAWLGTGTQVSAVPWTGD----QVGG
CSKPGFEDQAIGGGFWAGAGDQTTGGSRPAVSED-QSSGGVSWGGAGGHVV---------
------------------------------------GGSR---TDQSSGTSWPGMG---S
QVSGGSWIGTV--DQ-TSGCTKSGFEDQ-TCGGGSWVGTGDQTSGESWPGSRASNE----
---ASGG-----S--RL-----------------DSQ-----------------------
--------------------------DQASGGSWIRSEDQASGRFLVSAEVEANEGFWFG
PGSEAFIGSWCWTEE-ATILPVAGMKDETSTESTSGTREETSISSGLGDE------KKTS
PESWTRSEEAA--------FTGTSDGGEAKTVAGAEAEVDPESKTRAETKAEAGAE--TK
VEAE------VRVETR--AEA-----GAAAATV--------SEAGAEAGARVEAG-----
------------------------------------------------------------
-------------------------------------------------------AGAEA
GTGFWPWNG-DDTTKGSRLGAEAEAGAGGG---------------------------VEA
GAETENSMGFWFWNGD--AAT------KG------SKLGTETEAE--TGIGTGTGTG--T
G--TGTGTGTGVGAGVEVQAV-----ADTSMGFWFWDGD--GAT--KGSRLGTES-----
--EAGVGAGAQAGA--E----------AVAGTS-MEFWSWDGDEATKASRLGAEAEPG--
------------------------A--------------------------------G--
------------------------------------------------------------
---------------V-----------------------------VAEPRAETSVGFWFW
NEDS------------------------TTKGSGLGTEVGAGL-----------------
---GSWTFSTNVNDGEDEEEEDELSRESSP-GI-EEIS----------------------
-LRTLFGAESEDSNDLRSI--------NEKD--VNSESGTGDKADDTKDQFDA-------
-ANGVDIRSWFYTGNENKCED-ESSSQVKVKKSTE-S----------RGIYPSM-VPGAG
MGVW----DGTIVCSESK--LL------------HK----TSFPGED----G-----FR-
RQ-V-----------------------------------ST------------GVKVHSC
NCRCKR------TVNLDPHDLEKLICMIEMTEDPSVHEIATNALYNSADYPYPQ------
----------EIDRNIGGISVIQSLLSNPYPNV------RQ-KALNALNNI-SVAAENHR
TVKTYLSQVCEDTVTYPLNSNVQVAGLRLIKHLTITSEYQHMVTNYISEF-LRLLALGSG
E-TK-DHVLGMLVNFSKNPSMTRDLLIAN---APTALINIFSKKETK----------ENI
LNALLLFENINRHFKKRGKTYPQ--------DR-FSK--TSLY-FLFQRPKACAKKLRAL
AADCSDPEVKERVEVLINKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------MTGAEIEPSVQAKPEKKAGEEV--------IA-----------GAERENDVPL
VVRPKV--------------------------RTQ--ATTGARPKTETKSVPGARPKTDA
------QAMSGA------------GPKT----------------------------EAQV
MGGARPKT----------------------------EAQGMAGARPKTD------ARAVG
GTRPKT--DAKAIPGTRPKDEA--------------Q--------------AWSQSEFG-
-----TEAVSQAEGVSQTNAVAWPLATAES--GSVNKSKGLSMDRELVDVDAETFPGTQ-
-GQKGIQPWFRPG-EETN------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---MGSWCYSRPRAR-EEASNESGFWSADETSTV-SFWAGEETSIRSWPREES---NTRS
RHRAKHQ-----T--NPRSRPRSKQEAYVDS-WSGSE-----------------------
-DEAGNLFSFWAGENTSNLF----------------------------------------
---------------------RPRVREEANTRSKLRTNREDC--FESESE------DEFY
KQSWVLPGEEA---------NSR-----FRCRDKEDPNTALKPR----------------
AQ----KDV-DGDRVKQEPRF-----EEEVIVGSWFWAEKEA------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------SL
EGG------ASAICESEPGTE-----EGAI------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------GGSTYWAEEKS
SLGA--------------------------------------------------------
-----------------------------------------------VAREEAKPES---
------------------------------------------------------------
------------------------------------------------------------
-EEEAIFGSWFWDRDEACFDL-NPCPVYKVSDRFRDAA-EELNASSRPQTWEEVTVEFKP
-GLF----HRVGFRSTSPFRIPEEAS-----EMLEAKPKNMELSPEG----E--EQESLL
QPNQ--PSPEFTFQYDPSY--------------------RSVREIREHLRARESAESEGW
SCSCIQ-----CELKIGSEEFEELLLLMDKIRDPFIHEISKIAMGMRSASQFTR------
----------DFIRDSGVVSLIETLLNYPSSRV------RT-SFLENMIHM-APPYPNLN
MIETFICQVCEETLAHSVDSLEQLTGIRMLRHLTMTIDYHTLIANYISGF-LSLLTTANA
R-TK-FHVLKMLLNLSENPAVAKKLFSAK---ALSIFVGLFNIEETN----------DNI
QIVIKMFQNISNIIKSGKMSLID---------DDFSL--EPLI-SAFREFEELAKQLQAQ
IDNQNDPEVGQQS-----------------------------------------------
-------------------------------------------

------------------------------------------------------------
--------------------------------------------MGRIQEVGWVTAGLVI
WAGTCYYIYKFTKGRAQSVRTLARNGSTV-KMETVVG----VQSQTLAINEAE----IKT
KPQVEIGAETGARSGPGAEVETKAAAIAIHRANSQ----AKAMVGAEPETQSE-------
SKVVAGTLVMTEAVTLTEVK--AKAREVAMKEAVTQTDAEAGKIVKKEAVTQTK-AKAWA
LVAKTEAKREAMTQTKAETHILAEKETEINRVMVTQSETLAAPRE----VAKMGATNKTG
IVDETKTRALEETVSVAKTQSEARPGATVDARGNLNGMSREVAGVDMKSCAQSQAVTKIQ
GDDMPGTGVEDMGNCK---------------------------TMSRAESGADTRASAQP
QIFAKTQTEAIPGAKIDAGGNTNAMCKVGAGADVRACI-QPQTVAKKQAEVTSGAR-VDG
RGNTNVISKAITGADMRAAAQPQAVASTHAEAMSDAKVKNRGNPNAMTKAGAKANLRANS
QVEALPDARDKSRGNPNAMAKVGDGTDMLSCT-QPQLVASVQADTLSDGKIKVRGNVNTM
PKEGAGVDMKAQ--GMAQSQGEALPNTRGKARGKAKAKCKTGPGMDMKTCTQPQAGVKTP
AEALLDSRVDGRGNPNATSKAGTKADQRVCGQSLVVANPQGEALPGAKNKVKGNPHTVLK
VGAGEGTTDSAQPEAV---------------------------------------VSFQG
EALLGTKNKVKGSPNVVLKAEVGAGAMGTAQLQIMASSKGEALLDSKNKVKGNSNAVSKA
GAGTDTTGSVQPQIVANSQGEVLPGAKNKVRGNPTTVPNSGVGPYT--------------
--------------------------TDCARPQAVANSQGEVLPGAKNKVKANLNAVSKA
EAGMGAT-----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------GSVQPQAVANSHCETLPGAKNK
VRGNWNAVSKAGAGMDTRGSAQPQAVANSQGEVLPGAKNKVKGNPNVVSKAGAREDTVGS
TQPQVLASSQRETLPGARNKVKGNSNVVSK-----AGAREDTMGSAQPQVVANSQRETLP
GARNKVKGNSNAISKAEAGAGIMGSVQVQVVASSQGEVLPGAKNKVRGN--SNAVPKAEA
GADTVGSAQLQAVANSQSETLLGARNKVKGNTIAVPKAGTGAGTRHSAQPQIVAGSQ---
-------------------------------------GETLPGARDKSMSTSEAEATAED
EAYAKPE--AEAMPTSESEGGSGTQACRKTQPNIHDYYWNGIGVEDWIAAERWIKFRFQT
MDGDWENSVSWADDENEASIGSWSGA-SDK--AGIIRSWAVAC----DETSVKSWAGARA
ENVVGIGTWARAG-EQASGGLWAGGQTSEGTWAGD------------KASGGAWTGAENQ
ASGGSWALTGNQAIGELWAAGQASDGSWPGGQASGVSWVGEEAIGGSWTG--------AE
NQASEGSWAGA------------------------GAGNMSSVSYWAGVVDQAGG-GSWA
GT------------SDQSGGGSKPRFEDQASGEGSWAGAGGQASGGSMLGPEDQSSGRSW
ADTADQASGGSRLGHVDQSSGG--------------------------------------
----------AWAGTLDQSGGGSKPRFENQTTEEG-SWAGAGGQAGGGSKVGPEDQSSGR
SWANSGDQISGGFLVGIVDQANGGSWTGA----GHPASVGPKPIFEDQVSGRGSWA-DAG
EQVVGDSRLGLRDQSSGDSWAGTGDQASG------------WF-------------CVCP
G---SQ-TNGGSWGGASGQDVGGSRPGPMNQSSAGSWDSTGSQVSGSCWTGAGAVDQAGG
CSKPGFEDQAIGGGFWPGAGDQTGGGSRPGSEDQS--SGIGSWGVAGGQVL---------
------------------------------------GGARPGPADQSSGGSWAGTG---N
QSSGRSWIGPG--DQ-AVDCSKPEFEDQ-ACGGGSWAGAGSQASGESWAGSRPGNE----
---AIGG-----S--RM-----------------GSE-----------------------
--------------------------DQATGGSWARSEDQASGRFQVSFEVEANEGFWFG
PGAEAVIGSWCWTEEKADIVSRPDDKDEATTASRSGAGEEAIICSRTEAE------NKAS
SGSWIRSEEVA--------YMGSCVGAEAGAGA--------------EAGAGAWSW----
---------------------------------------------DGD------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------ATTVESRL-----------------------------GAGEEAGSGAGVWSW
DGDA------------------------TTVESRLGAGEEAGV-----------------
---ESWTLARD------V-GEDELSRESSP-DI-EEIS----------------------
-LRSLFWAESENSNTFRSK--------SGKD--ANFESGAGDNT-SIKDKFEA-------
-AGGVDIGSWFCAGNENTSED-KSAPKAKAKKSSE-S----------RGIYPSM-VPGAG
MGSW----DGAMIWSETK--FA------------HQ--SEASFPVED----E-----SR-
KQ-T-----------------------------------RT------------GEKTRPW
SCRCKH------EANMDPRDLEKLICMIEMTEDPSVHEIANNALYNSADYSYSH------
----------EVVRNVGGISVIESLLNNPYPSV------RQ-KALNALNNI-SVAAENHR
KVKTYLNQVCEDTVTYPLNSNVQLAGLRLIRHLTITSEYQHMVTNYISEF-LRLLTVGSG
E-TK-DHVLGMLLNFSKNPSMTKDLLIAN---APTSLINIFSKKETK----------ENI
LNALSLFENINYHFKRRAKAFTQ--------DK-FSK--NSLY-FLFQRPKACAKKLRAL
AAECNDPEVKERVELLISKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
--------------------------------------------MGRIQEVGWVTAGLVI
WAGTCYYIYKLTKGRSQSVRTLARNESTV-KMETVVE----VQNQTLAIGEAE----IET
KSQAEIEAETGAGGGPGAEVETKATAIARHKASSQ----AKAMIGAEAEIQSE-------
SKVAAGTLVMTEAVTLTEAK--AKAREVAMKEAVTQTDAEAGKIVKKEAVTQTK-AKAWA
LVSKTEAKREAMTQTKAETHILAEKEAEINRVMVTQSETLAVPGE----VAKMGATNNTG
IVDETKTRALEETVSVVKTQSEARPGSTVDARGNPNGMSREVAGVDMKSCAQSQAVTKIQ
GDDMPGARVEDMGNCK---------------------------TMSWEEPGADMRASAQP
QIVAKTQIEAIPGAKVDAEGNTNAMCKVGAGADVRTCM-QPQTVAKKQAEVMSGAR-ADG
RGNTNVISKAITGADMRAAAQPQAVASPHAEAMSDAKVKERGNPNAITKAGARTNLRANS
QVEALPNARDKSRGNPSVMANMEDGADMLSCT-QPQLVAIVQANTLSDGRIKVKGNVNSM
PKEGSGMDMKAQ--GMAQSQGEALPNTRGKSRAKAKAKCKTGAGMDMKNCAQPQAGSKTP
AEALPDSRVDGRGNLNAMSKAGTKADQRACGQPLIVANPQGEA---SKNKAKGNPHAVLK
VGAGEGTTDSAQPQAV---------------------------------------VSFQD
EALLGTKNKVKDNPNAVLKAEVGAGAMGTAQLQIVASSKGEALLDSKNKAKSNSNAVSKA
GAGTDTMGSAQPQIVANSQSEVLPGAKNKVRGNPTTMPNSGAGPYI--------------
--------------------------TDSAQPQAVASSQGEVLPSAKNKVKANLHALSKA
EAGMGAT-----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------GSVQSQAVANSQGETLPGAKNK
VRGNWNTVSKAGAGIDTTGSAQPQAVAGSQGEVLPGAKNKVKGNPNVVSKAGAREDTTGS
AQP---------------------------------------------QVVANSQHETFS
GARNKVKGNSNAISKAEPGSGIMGSVQVQVVASSHGKVMPGAKNKVRGN--SSAVPKAEA
GADTVGSGQPQAVANTQRETLLGARNKVKGNTKAVSKAGTGAGTRDSAQPQIVTGSQ---
-------------------------------------GETLPRARDKPMPSSEAEATAED
EVYAKAE--AEAMPTSESEGGSGAQACRKTQPDIHDYYWNGIGVEDWIAAERWIKFRFQT
MDGDWENGVSWADDENEASTGSWSGA-SDK--AGIISSWAVAC----DEASVKSWAGARA
ENEVSIGTWVRAG-EQASGGLWVGGQTSEGTWAGD------------KASGGAWTVAENQ
ASGGAWVVAGNQAFGEIWAVGQASDGSWPGGQASGVSWVGEQAIGGSWTG--------AE
NQATGGSWAVV------------------------GAGNMSSVSYWAGVVDQASG-GSWA
GI------------SDQSSGGSKPRFEDQASGEGSWAGAGGQASGGSRLEPEEQSSGRSW
ADTVDQASGGSRLGHVDQTSGG--------------------------------------
----------SWAGTLDQSAGGSKPRFESQTTEEG-SWAGASGQAGGGSKLGPEDQSSGR
SWANSGDQISGGFLVGVVDQANGGSWTGA----GHPASGGPKPIFEDQASGGGSWA-DAG
DQAVRDSRLGPRDQSSGDSWAGTGDQASG------------WF-------------CVCP
G---SQ-MNGGSWGVASGQDVGGSRPGPTNQSSAVSWDSAGSQVSGSSWTGVRAVDQAGG
CSKPGFEDQAIGGVFWPGVGDQAGGGSRPASEDQS--SGRGSWGMAGGQVF---------
------------------------------------GGSRPGPADQSSGGSWASTG---N
QSSGRSWIGPG--DQ-ASDCSKPEFEDQ-ACRGGSWAGAGNQASGESWAGSRLGNE----
---ATEG-----S--KM-----------------GSE-----------------------
--------------------------DQATGGSWARSEDQASGRFQVSVEVEANEGFWFG
PGAEAVIGSWCWTEEK-VILSRPDDKDEATTESRSGDGEEAIICSRIEAE------NKAS
SGSWIRSEEVA--------YMGSSVGAESGAGA--------------WSWDG--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--DAGAGAW--------------------------------------SWDGDAGAGAWSW
DRDA------------------------TIIESRLGAREEVDV-----------------
---ESWTLAWD------V-DEDDLSRESSP-DI-EEIS----------------------
-LRSLFWAESENSNKFRSK--------NGKD--VNFESGAGDNT-RIKDKFEA-------
-SGGVDIESWFCDGNENTSED-KSAPKGKGKKSPE-S----------RGTYPSM-VPGAG
MGLW----DGAMIWSETK--FP------------HH--SEASFPVED----E-----SK-
KQ-T-----------------------------------KT------------GEKTRSG
SCHCKR------EANMDPQDLEKLICMIEMTEDPSVHEIANNALYNSADYPYSH------
----------EVVRNVGGISVIESLLNNPYPSV------RQ-KALNALNNI-SVAAENHR
KVKTYLNQVCEDTVTYPLNSNVQLAGLRLIRHLTITSEYQHMVTNYISEF-LRLLTVGSG
E-TK-DHVLGMLLNFSKNPSMTKDLLIAN---APTSLINIFSKKETK----------ENI
LNALSLFENINYHFKRRAKAFTQ--------DK-FSE--NSLY-FLFQRPKACAKKLRAL
AAECNDPEVKERVELLISKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
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-----------------------MTDSRARARTRGGAGVDLKAG--------IKDP----
------SKARAKAKTQAKAVA-----VAEPKTGSV----TQAKTGDGAVAKTRTMAHTDA
--LTMMRKVSKV------------------------------------------------
------------------------------------------------------------
-----------ETMTKTRIMPETKSKTPV-EHGVVPKTKPRTMLESRV--SVKTKSEIKA
S-----------------------------------------------------------
-------AGSGVNIRSCAKAD-----GKSNIGSRPQT-----------------------
--------SEEAGIKLR----------A--------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------EDKAGIGI-----------------------------KSSDEDEKNVCSWFW
TGEE------------------------PSVGSWFWPEEETTPQV---------------
-----YKPPPK---------------------I-HEKP----------------------
------------------------------------------------------------
----------------------KPT--SK----------------------PELTIKQKA
-AAW----SRA--RYSVLVPVE------------GG--ERS-LPP---------EGNWTL
VETLIET--------PLGIRPLTKIPPYNGPYFQTLAD------IKKQVRYREKYGPNPK
ACRCKL-----RNFSLEPKEFDKLVALLKLTKDPFIHEMATMVMGISPAYPFTQ------
----------DIIHDVGVTVMIENLINNPNVKE------HP-RALNMVDDS-SESSEELK
SGESYINQVCKDILSYPMNSPVQLAGLKLLGHLSVKFDDHHMIANYIPDF-LTLLNKGSV
K-TK-FYVLKVFLCLSKNQANTRELISAE---VLSSLIAPFNKNESK----------ANI
LNIIAIFENINFQFKKKVKLFTK--------EQ-FTK--SELI-SIFQEAKEFGQKLQDL
A-EHSDPEVRDKVIRLILKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
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-----------------------------------------------------E---DLT
NGSYD--------DVLNAEQLRKLLYLLESTQDPVIIEKALVTVGNNAAFSVNQ------
----------AILRELGGIPIVGNKINSPNPSI------KE-KALNALNNL-SVNVENQI
KIKIYINQVCEDVFSGPLNSAVQLAGLRLLTNMTVTNDHQHMLHSYITDL-FQVLLTGNG
S-TK-VQVLKLLLNLSENPAMTEGLLSAQ---VDSSFLSLYDGHIAK----------EIL
LRVLTLFQNINNCFKMEGCSAS----------QHFTK--GSLFFLLYGE--ECAQKIRSL
V-HHHDTEVKEKVVTIIPKI----------------------------------------
-------------------------------------------

------------------------------------------------------------
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---------------------------------MSRVRDAGCVAAG----------IVIG
ASAWYCVYKYA--RGRNHMMKKRLA----KPKTRA--VAETGARARAGLRAGFTIDLGPG
FSPPTPVRTGAEER-AQDESSALDTAGVEAVVPAA------SSAETQSGAGNKGQETEGA
--WVGLKAES---VATVAFAVAPPLWEAKAP------------LAAKAPTMVGAPKLAEA
PGA----------------A--------EAPRAPVVPHVVPVPTEASQPTEPV-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------EASI------------PAMPT---------
------------------------------------------------------------
------------------------------------------------GAAATLGV----
---AA-----------PSGTA-----------------E-AP------------------
----------------------GPSGSSR-------------------------------
-----------TAA-----ATKKATPGAHTGAIPKAGS--ATGA---VPKGGA-------
-----------KGVTRSRTGG-K----GKGK-------------K-NKVEVDELGLGFRP
GD---------GAAAAAAASAN------------GGQAFLAEVPDS-----EEGESGWTD
TESESDSEPETQQKGKG----------------------------RR----PVPMQKRPF
PYEID--------EILGVRDLRKVLALLQKSDDPFIQQVALLTLSNNANYSCNQ------
----------DTIRKLGGLPIIANMINKTDPHI------KE-KALMAMNNL-SENYENQG
RLQVYMNKVMDDIMASNLNSAVQVVGLKFLTNMTITNDYQHLLVNSIANF-FRLLSQGGG
K-IK-VEILKILSNFAENPDMLKKLLSTQ---VPSSFSSLYNSYVES----------EIL
INALTLFEIIYDNLRAEVFN-----------YREFNK--GSLFY-LCTASGVCVKKIRAL
A-DHHDLLVKVKVIKLVDKF----------------------------------------
-------------------------------------------

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---------------------------------MGRTREAGCVAAG----------VVIG
AGACYCVYRLT--WGRDE-NEIIWN----EDDDEEEE--SRD------------------
------------------------------ISETG------KGAKANAGAGAGARLQGDA
-----------------------------KA------------KAEVAVELKSGPDVKAE
AHS----------------K--------AESGGGLE---AKA------------------
-----------------KALFSTL--------------K---------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------EQASAKAGKAAKLGTIF--------------------------
---------------------------------------------GTRALAPGFPCLGVR
GG---------GCHPVRSGARA---------------------------------GSKDS
GKSKGRTRSKSTRTPA-L---------------------------LW----PVRKGKFNF
PYKID--------DILGATDLQKVLNILERSNDPFIQEVALVTLGNNAAYSFNQ------
----------NAIRELGGLPIIAKLIKTKDPII------RE-KAYNALNNL-SVNSENQG
KIKIYISQVCDDTMLCRLDSAVQMAGLRLLTNMTVTNHYQHLLSYSFPDF-FALLFLGNY
F-TK-IQIMKLIINFTENPAMTRELVSCK---VPSELISLFNKEWDR----------EIL
LNILTLFENINDNIKNEGLASS---------RKEFSR--SSLFF-LFKESGVCVKKIKAL
A-NHSDLVVKVKVLKVLTKL----------------------------------------
-------------------------------------------

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---------------------------------------MTGSKN--KARAQAKLEKR-A
SAQARAVAEREAANA------NRGA---------------------GKSRDKGKGKAGSK
-----SDAV---------------------------------------------------
------AEVKAG-------------SKGKVVAETKEGARPESKALVKGT-----------
-----SDF----------------------------NHRTENKFARSTRKDKPSSDNWFW
AGED------------------------SGINSWFWKGEELSN-NSVA------------
---------KCENK-------PSTSIQARA----E-------------------------
------------E--PAPRTSHKSRSGAEE------------------------------
EEEENVIGNWFWEGDDTGFDT-DPKPVFKIVKPQP---VDEINEKDRPKDWSEVTIWPKA
PAVTP---AVLGYRSQDSSEARSSS----YIVLASNEEETST------------A-CTKN
TRSSLQSIPEYPFGSDPCI--------------------QTLDEIRQQIKIREENGIKPF
ACPCKL------ECYLDSPEFEKLVNILKSTTDPLIHKIAQIAMGIHKVHPFAQ------
----------EFINEVGVVTLIESLLSFSSPEV------SIKKAVITL-N--SSGDDRYN
KVEFHVKHMCKETVSFPLNSPGQQSGLKIIGQLTTESVHHYIVVSYFSEL-FHLLSQGNR
K-TR-NLVLKVFLNMSENPKAARDMINMK---ALAALKLIFNQKEAK----------ANL
VSAVAIFINIKEHIRKGSIVVVD----------HLSY--NTLT-AIFREVKGIIERM---
------------------------------------------------------------
-------------------------------------------

------------------------------------------------------------
--------------------------------------------MGRIQEVGWVTAGLVI
WAGTCYYIYKFTKGRAQSVRTLARNGSTV-KMETVVG----VQSQTLAINEAE----IKT
KPQVEIGAETGARSGPRAEVETKATAIAIHRANSQ----AKAMVGAEPETQSE-------
SKVVAGTLVMTEAVTLTEVK--AKAREVAMKEAVTQTDAEAGKIVKKEAVTQTK-AKAWA
LVAKTEAKREAMTQTKAETHILAEKETEINRVMVTQSETLAVPRE----VAKMGATNKTG
IVDETKTRALEETVSVAKTQSEARPGATVDARGNPNGMSREVAGVDMKSCAQSQAVTKIQ
GDDMPGTGVEDMGNCK---------------------------TMSRAESGADTRASAQP
QIFAKTQTEAIPGAKIDAGGNTNAMCKVGAGADVRACI-QPQTVAKKQAEVTSGAR-VDG
RGNTNVISKAITGADMRAAAQPQAVASTHAEAMSDAKVKNRGNPNAMTKAGAKANLRANS
QVEALPDARDKSRGNPNVMAKVGDGTDMLSCT-QPQLVASVQADTLSDGKIKVRGNVNTM
PKEGAGVDMKAQ--GMAQSQGEALPNTRGKARGKAKAKCKTGPGMDMKTCTQPQAGVKTP
AEALLDSRVDGRGNPNATSKAGTKADQRVCGQPLVVANPQGEALPGAKNKVKGNPHTVLK
VGAGEGTTDSAQPEAV---------------------------------------VSFQG
EALLGTKNKVKGNPNVVLKAEVGEGAMGTAQLQIMASSKGEALLDSKNKVKGNSNAVSKA
GAGTDTTGSVQPQIVANSQGEVLPGAKNKIRGNPTTVPNSGVGPYT--------------
--------------------------TDSARLQAVANSQGEVLPGAKNKVKANLNAVSKA
EAGMGAT-----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------GSVQPQAVANSHCETLPGAKNK
VRGNWNAVSKAGAGMDTRGSAQPQAVANSQGEVLPGAKNKVKGNPNVVSKAGAREDTVGS
TQPQVLASSQRETLPGARNKVKGNSNVVSK-----AGAREDTMGSAQPQVVANSQRETLP
GARNKVKGNSNAISKAEAGAGIMGSVQVQVVASFQGEVLPGAKNKVRGN--SNAVPKAEA
GADTVGSAQPQAVANSQSETLLGARNKVKGNTIAVPKAGTGAGTRHSAQPQIVAGSQ---
-------------------------------------GETLPGARDKSMSTSEAEATAED
EAYAKPE--AEAMPTSESEGGSGTQACRKTQPNIHDYYWNGIGVEDWIAAERWIKFRFQT
MDGDWENSVSWADDENEASIGSWSGA-SDK--AGIIRSWAVAC----DETSVKSWAGARA
ENVVGIGTWARAG-EQASGGLWAGGQTSEGTWAGD------------KASGGAWTGAENQ
ASGGSWALAGNQAIGELWAAGQASDGSWPGGQASGVSWVGEEAIGGSWTG--------AE
NQASEGSWAGA------------------------GAGNMSSVSYWAGVVDQAGG-GSWA
GT------------SDQSGGGSKPRFEDQASGEGSWAGAGGQASGGSMLGPEDQSSGRSW
ADTADQASGGSRLGHVDQSSGG--------------------------------------
----------AWAGTLDQSGGGSKPRFENQTTEEG-SWAGAGGQAGGGSKVGPEDQSSGR
SWANSGDQISGGFLVGIVDQANGGSWTGA----GHPASVGPKPIFEDQVSGRGSWA-DAR
EQVVGDSRLGLRDQSSGDSWAGTGDQASG------------WF-------------CVCP
G---SQ-TNGGSWGGASGQDVGGSRPGPTNQSSAGSWDSPGSQVSGSCWTGAGAVDQAGG
CSKPGFEDQAIGGGFWPGAGDQTGGGSRPGSEDQS--SGIGSWGVAGGQVL---------
------------------------------------GGARPGPADQSSGGSWAGTG---N
QSSGRSWIGPG--DQ-AVDCSKPEFEDQ-ACGGGSWAGAGSQASGESWAGSRPGNE----
---AIGG-----S--RM-----------------GSE-----------------------
--------------------------DQATGGSWARSEDQASGRFQVSFEVEANEGFWFG
PGAEAVIGSWCWTEEKADIVSRPDDKDEATTASRSGAGEEAMICSRIEAE------NKAS
SGSWIRSEEVA--------YMGSCVGAEAGAGA--------------EAGAGAEAG----
---------------------------------------------AGAGAE---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------AGAEAGAGA-----------------------------GAGPGTESGAGIWSW
DGDA------------------------TTVESRLGAGEEAGV-----------------
---ESWTLARN------V-GEDELSRESSP-DI-EEIS----------------------
-LRSLFWAESENSNTFRSK--------SGKD--ASFESGAGDNT-SIKDKFEA-------
-AGGVDIGSWFCAGNENTSED-KSAPKAKAKKSSE-S----------RGIYPYM-VPGAG
MGSW----DGAMIWSETK--FA------------HQ--SEASFPVED----E-----SR-
KQ-T-----------------------------------RT------------GEKTRPW
SCRCKH------EANMDPRDLEKLICMIEMTEDPSVHEIANNALYNSADYSYSH------
----------EVVRNVGGISVIESLLNNPYPSV------RQ-KALNALNNI-SVAAENHR
KVKTYLNQVCEDTVTYPLNSNVQLAGLRLIRHLTITSEYQHMVTNYISEF-LRLLTVGSG
E-TK-DHVLGMLLNFSKNPSMTKDLLIAN---APTSLINIFSKKETK----------ENI
LNALSLFENINYHFKRRAKAFTQ--------DK-FSK--NSLY-FLFQRPKACAKKLRAL
AAECNDPEVKERVELLISKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
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---------------------------------MGYARKVGWVTAG----------LVIG
AGACYCIYRLT--RGRKQNKEK-MA----EGGSGDVD--DVG----------------DC
---------------------------------------------------------PGP
--RYNDWSDDD-------------------------------------------------
DDN----------------S--------E-------------------------------
------------------------------------------------------------
-NKGIVWYPPWAR-----------------------------------------------
------------------------------------IG----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------T--------------------------------
-----------EAGTRARARA---------------------------------------
------------------------------------------------------------
-------------RARAT---------------------------RA----RRAVQKRAS
PNSDD--------TILSPQELQKVLCLVEMSEKPYILEAALIALGNNAAYAFNR------
----------DIIRDLGGLPIVAKILNTRDPIV------KE-KALIVLNNL-SVNAENQR
RLKIYMNQVCDDTITSRLNSSVQLAGLRLLTNMTVTNEYQHMLANSISDF-FRLFSAGNE
E-TK-FQVLKLLLNLAENPAMSRELLRAQ---VPSSLGSLFNKKENK----------EVI
LKLLVIFENINDNFKWQENEPT---------QNQFSE--GSLFS-FLKEFQACADKILGI
E-SHHDFLVKVKVGKFMAKLAEHMFPKSQE------------------------------
-------------------------------------------

------------------------------------------------------------
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---------------------------------MSRVRDAGCVAAG----------IVIR
AGAWYCVYKYT--RGSNQ-TKKRMV----KPKNRA--VAGTGARARAGLRARFTIDLGPG
FSPPTPVSAGTEDR-AQDEASALEAAGAEAVAPAA------SSIEVQSGAGSQAPEADGA
--RVGPKT-ESVVGAAVASAIAPPPGVAEAP------------AAAEAPVMTGTPKMAEA
PST----------------G--------EAPRAAAPPRTVVAAPI---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------EATEAPK------------VAAPTRV-------
--------------------------------------------------------AEAP
GVAVPPEAAEAPVPTMP------------------------------TG------T----
---AA-----------PTGAA-----------------E-VP------------------
----------------------GTSGSSR-------------------------------
-----------TAAVPGTAAAKKATPGAHTGAIPKAGS--ATGA---VPKGGA-------
-----------KGGTRSRNGG-K----GKGK-------------K-IKVEVDELGMGFRP
GD---------GAAAAAAASAN------------GGQAFLVEVPVS-----EEGESGWTD
TESDSDSEPETQRRGRG----------------------------KR----PVSMQRCPF
PYEID--------EILGVRDLRKVLALLQKSDDPFIQQVALLTLSNNANYSCNQ------
----------ETIRKLGGLPIIANMINKTDPHI------KE-KALMAMNNL-SENYENQG
RLQVYMNKVMDDIMASNLNSAVQVVGLKFLTNMTITNDYQHLLVNSIANF-FRLLSQGGG
K-IK-VEILKTLSNFTENPDMLKKLLSTQ---VPASFNSLYNSYVES----------EIL
INALTLFEIVYDNLRAEVFN-----------YREFNK--GSLFY-LHTASGVCIKKIRAL
A-NHHDLLVKVKVIKLVNKF----------------------------------------
-------------------------------------------

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---------------------------------------MTGTKN--RTRAQAKTEKK-P
VTQAEAGAEREATGV------VRPV---------------------AKTRAKAKAKTGSK
-----TDAV---------------------------------------------------
------AEMKAV-------------SKNKVVAEVKERALSEPKTLGKAM-----------
-----GDF----------------------------SSKAGNESTSSTCKNEAGIDAWFW
AGEE------------------------ATINSWFWNGEEAGN-SSST------------
---------KNDKP--------EIGAQVCA----E-------------------------
------------ELEPAAGADCKPRSGAEE------------------------------
EEEENVIGNWFWEGDDTSFDP-NPKPVSRIVKPQP---LYEINEKNRPKDWSEVTIWPNA
PAVTP---AVLGFRSQAPSEASPPS----YIVLASAEENACSLPGA------TACRPSRN
TRSCSQPIPECRFDSDPCI--------------------QTIDEIRRQIRIREVNGIKPF
ACPCKM------ECYMDSEEFEKLVSLLKSTTDPLIHKIARIAMGVHNVHPFAQ------
----------EFINEVGVVTLIESLLSFPSPEM-------RKKTVITL-NP-PSGDERQH
KIELHVKHMCKETVSFPLNSPGQQSGLKILGQLTTDFVHHYIVANYFSEL-FHLLSSGNC
K-TR-NLVLKLLLNMSENPTAARDMINMK---ALAALKLIFNQKEAK----------ANL
VSGVAIFINIKEHIRKGSIVVVD----------HLSY--NTLM-AIFREVKGIIETM---
------------------------------------------------------------
-------------------------------------------

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---------------------------------MGYARKVGWVTAG----------LVIG
AGACYCIYRLT--RGRKQNKEK-MA----EGGSGDVD--DVG----------------DC
---------------------------------------------------------PGA
--RYNDWSDDD-------------------------------------------------
DDN----------------S--------E-------------------------------
------------------------------------------------------------
-NKGIVWYPPWAR-----------------------------------------------
------------------------------------IG----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------T--------------------------------
-----------EAGTRARARA---------------------------------------
------------------------------------------------------------
-------------RARAT---------------------------RA----RRAVQKRAS
PNSDD--------TILSPQELQKVLCLVEMSEKPYILEAALIALGNNAAYAFNR------
----------DIIRDLGGLPIVAKILNTRDPIV------KE-KALIVLNNL-SVNAENQR
RLKIYMNQVCDDTITSRLNSSVQLAGLRLLTNMTVTNEYQHMLANSISDF-FRLFSAGNE
E-TK-FQVLKLLLNLAENPAMTRELLRAQ---VPSSLGSLFNKKENK----------EVI
LKLLVIFENINDNFKWEENESA---------QNQFSE--GSLFF-FLKEFQVCADKILGI
E-SHHDFLVKVKVGKFMAKLAEHMFPKSQE------------------------------
-------------------------------------------

------------------------------------------------------------
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-----------------------MVDSGTEARARGKAEAGLQDG--------ISGP----
------ATARVNGKTQAKAVA-----EAELKTESV----TQAKAGDGAMTRMHKVTYREA
--MAVTREVSKM------------------------------------------------
------------------------------------------------------------
-----------EDTTKSRVMVETKTKPLA-ERSIVPQTKSKAMPMSGV--SAVTKSEVKV
V-----------------------------------------------------------
-------AVIEANIRSYAKSH-----DKANTGSRSDR-----------------------
--------REEA------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------SIGM-----------------------------KSSDEDEENICSWFW
TGEE------------------------SSVGSWFWPEEETSLQV---------------
-----YKPLPK---------------------I-QEKP----------------------
------------------------------------------------------------
----------------------KPAHK------------------------PTLTIKQKA
-IAW----SRA--RYIVLVPIE------------GG--EQS-LPP---------EGNWTL
VETLIET--------PLGIRPLTKIPPYHGPYYQTLTE------IKKEIRQREKYGPNPK
ACHCKS-----RGFSLEPKEFDKLVALLKLTKDPFIHEIATMIMGISPAYPFTQ------
----------DIIHDVGITVMIENLVNNANVKE------HP-RALSIVDDS-SESSEEPK
SGESYIHQVCKGIVSCPLNSPVQLAGLKLLGHLSVKFDDHYVITSYIPDF-LTLLNKGSV
K-TK-FYVLKVFSCLSKNCANTRELISAK---VLSSLVAPFNKHESK----------ANI
LNIIEIFENINFQFKTKVKLFTK--------EK-FTK--SELI-SIFQEAKQFGRKLQDL
A-EHSDPEVRDKVIRLILKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
-------------------------------------------------SKTQTMTHSEA
--LAVTRGVSK-------------------------------------------------
------------------------------------------------------------
---------------KKKVVAETNAKMVA-EPRVVPRTNSKALAGSRV--SVMTQSEAKA
G-----------------------------------------------------------
-------ADSEANIKSCGKAD-----DKASIESGPQI-----------------------
--------NEEASVKSR----------AG-------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------NEADIGI-----------------------------KSNDEVEENVCSWFW
TGEE------------------------PSVGSWFWPEEETPPQV---------------
-----YKPPPK---------------------I-KEMP----------------------
------------------------------------------------------------
----------------------KPT--PK----------------------TELTIKQKA
-AAW----SRA--RYSVLVPIE------------GG--EQS-LPP---------EGNWTL
VETLIET--------PLGIRPLTKIPPYGGPYFQTLAE------IKKQIRYREKYGPNPR
ACRCKP-----RGFSLDPKEFDKLVALLKLTKDPFIHEIATMVMGVSPAYPFTQ------
----------DIIHDVGITVMVESLINNPNVKEHPNPQEHP-RALNMVDDS-SELSEESK
REESYINQVCKDIFSYPLNSPVQLSGLKLLGHLSVKFEDHHMIINYIPDF-LTLLNKGSV
K-TK-FFVLKVFSYLAKNQANTRELISAE---VLSSLVAPFNKNESK----------ANI
LTIIEVFENINYQFKKRVKLFTK--------EQ-FTK--HELI-SIFQEAKQFGQKLQDL
A-EHNDPEVRDKIIRLILKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
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-------MTGAEIEPAAQAKPEKKAGEEVG--------G-----------GAERENEVPL
VVRPKV--------------------------RTQAQAMPGARPKTETKSMPGARPKIVG
------------------------------------------------------------
------------------------------------------------G------QTQVG
VVHPKN--EAKAIPGSRPTDKA--------------H--------------SWAQTEFA-
-----GKAMLKTEGVSQTNTIAWPLVSTES--GSVAKSKTLSMDRELISMDTESFSGTRV
KFQSGKQPLFGPE-EKTN------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---VGSWWCPRPTSK-QEISHKSDFRWVDRSSLSSWFWSGEEVNTNFHPRGRVKA-SARS
RHIAREE---------AMSRPNTNQEFYILS-SSGSE-----------------------
-DESIKTSWFWTREKTNSWS--RPKEET-NNRSRFRSKKEVS-------------ESSSG
SECEDNVKSWFWAREEAKSRSKPRARRGANVRARHRAKQETSIDFLSGST------DVVK
KESWFWPGEKA---------NNL-----SRPKSKKEARARIMAK----------------
EK----VKTKARARAKQEARS-----EEEFLIGNWFWATEESSVVGGASVKHSSQVEDES
IVGAWFWTEEETSMRTDASSKS-SPKNEEESISNSVLGSG-EKTSMETGAEATSKSVVAY
DKE-KLIAGSCFRASEE-TN---------------------------------LEAEEET
IFGPWFWVSDEAS-VEADVRASCA-------------------------------STPR-
-SEEKEAIGPWFWDRKEVDTEAEFGED----------ASPEDEEETIFGSWFWAGNQAQI
DSG------VKISCDTMPGAE-----EEPIIGSWFWDGVEACVGTEVSNKSSLKDNEE-V
LISSWFGTMEEVSMKYGAGARCKFMAGPEEISNDSCFWDEDDPCMYSANGGSWKSRPEVE
-----QDTVDSSFWSRKYTSPETIIG------------------------PWLWATEEVS
IDDGTGEEVKPLMEEETMITSWFWKGD-ETIREATDREESGEDAEEEDIIGSWFWAGEED
RLKTAAEAREEDLLA-------------------------------EAEEEEATVGSWFW
AEEEA-NLEAGASFEPMPVIEEE----EIIFGSWFWPEEE-NIEVGPQAIEEGRSSPEEE
IIFGSWFCAAKE-----VSVEAEKCCASKPEDD--EII----------------------
-VESWFWSGEKDINETGTVVICESRPENEEGTVVGAWFGAKDEANNRTGYGTNCETQTVA
EEDEAIVGSWFWAGDEAHFES-NPRPVFRAICRSEYSFEQEPDASRRPQSWDEVTIQFKP
-GPW----GRVGFPSPIPFRFPKEA-ASLFSEMFGGKPKHMELNPEG----E--EQES-D
Q-----PEPEFPFQYDPSY--------------------RSVREIREHLKARDSAEPESW
SCSCIQ-----CELKIGTEEFEELLLLMDRIRDPF-------------------------
----------------GVVSLIETLLDIPSSRV------RT-SFLENMIRL-APPYPNLN
MIQTYVCQVCEETLAYSLDSPEQLSGIGMVRHLTTTTDYHTLVAKYMSGF-LSLLAMGNT
K-TR-FHILKVLLNLSENPVMTKELLSAE---AMSEFMGLFKRKETN----------DNI
QVVLAVFENIGNNIKKESVLFA---------DDDYSL--EPLI-STFHEVEKFAKEMQGK
RAGPEDP-----------------------------------------------------
-------------------------------------------

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---------------------------------MSRVRDAGCVAAG----------IVIG
AGAWYCVYKYT--RGRDQ-TKKRMA----KPKNRA--VAGTGARARAGLRAGFTIDLGSG
FSPPTPVRAEAEDR-AQDEASALDTVGAEAVAPAA------SSAEAQSGAGSQAQEADGA
--GVGPKA-ESVVGAAMASAIAPPPGVTEAL------------GAAEAPAMAGAPKVAEA
PRE----------------A--------ETSRAA-VPPGTVVPTEA-AA-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------PTEVTEGPG------------VAAPT---------
---------KVA---EAP------------------------------------G-----
-VASPTEAAEAPVPATP------------------------------TG-----AA----
---AP-----------T-GAA-----------------E-SP------------------
----------------------GTSGSPR-------------------------------
-----------TAVVPGTSAAKKATPGAHTGAIPKATS--ATGA---VPKGGG-------
-----------KGVTRSRNGG-K----GKGK-------------K-SKVEVDELGMGFRP
GD---------GAAAAAAASAN------------GGQAFLAEVPDS-----EEGESGWTD
TESDSDSEPETQRRGRG----------------------------RR----PVAMQKRPF
PYEID--------EILGVRDLRKVLALLQKSDDPFIQQVALLTLSNNANYSCNQ------
----------ETIRKLGGLPIIANMINKTDPHI------KE-KALMAMNNL-SENYENQG
RLQVYMNKVMDDIMASNLNSAVQVVGLKFLTNMTITNDYQHLLVNSIANF-FRLLSQGGG
K-IK-VEILKILSNFAENPDMLKKLLSTQ---VPASFSSLYNSYVES----------EIL
INALTLFEIIYDNLRAEVFN-----------YREFNK--GSLFY-LCTTSGVCVKKIRAL
A-NHHDLLVKVKVIKLVNKF----------------------------------------
-------------------------------------------

------------------------------------------------------------
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----------AIIRELGGIPIVGSKINSLNYSI------KE-KALNALNNL-SVNVENQI
KIKTYINQVCEDVFSGPLNSAVQLAGLRLLTNMTVTNDHQHMLNSYVADL-FRVLLTGNG
N-TK-XXXXXXXXXXXXXXXX---XXXXXXXXVDSSFLSLYDGHTAK----------EIL
LRALTLFQNINNCLKMEGRIAI---------QPTFTK--GSLFFLLYGE--ECAQKIRAL
I-YHHDVEVKEKAAAVILKF----------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
-------MTGAEIEPGAQAKTENKGTDEVG--------------------VAEGDNEVPM
VVRPKV--------------------------RT--QTMTGTRPKMKSRGMPGARSKS--
------------------------------------------------------------
------------------------------------------------E------PSTGD
VTHTNY--KTKAVSSSRSKNDA--------------Q--------------AWAQSKFW-
-----VDSKSKTGEKSSASAANCPLVGTDC--GLVGKAKCPPGGRELINMDTKNFPKKKA
NSQMGFQPSCELE-EATN------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---IGSWCSARPVPK-EETYQTSDFKWVDKPFGSAWFSSRDEGSTRFHPRKSMKA-SSRS
RHMAKPE-----A--NPISKHKNNQEFYMIS-SSESD-----------------------
-DESNKTSWFWGKEQSNPWS--RSREEA-NNRSWFRPNREVYA------------ESSSG
SEYENQTKSWLWPGEEAKARSKLRTRKGASSKARYQTKQEICTDVMPGSN------DTIK
KESWLWPEEKA---------SDF-----LRPKTKKETRSTLMAK----------------
EE----SKTKARARAKQEARS-----EEEALIGSWFWATEESTMVDEVSIKSSPHVEDEP
IVGNWFWTEEEACVGNGTSHKS-RPSAKEEQVVNFCLDTG-NKNNIEIGAQAASKPMVAA
NDD-ETIVGSWFWTDEE-VQ---------------------------------PENEEEN
VFGSWFWGIDDPS-GRCAARVSCE-------------------------------STPR-
-CEEKEVTNSWFWARE-VDTEAEVEEQ----------TRSGSEEGSVFLSWFWSEKQPPV
NSG------AEASCDIRTGAE----EEEPIIGPWFWGRVDAGVDAEVNSKSSLVDEEE-P
IISSWFGAGEEASIKCGVGARCKLMEEADDTDGRSCIWAEEEPCVYSPNTESLKSALE-E
-----EDSVDSWLWSKNYTRPETVVGS-----------------------SWLWAAEQGN
IDNETGEEIKLPTVEENIFK--FWKENEKAIIEATDREESRSEAEEEDIIGPWFWTGEED
RLEAPAETREQSK-IGAEEEATVGSWFWMDEP----------------------------
-----------------------------------------SPEAESQALEEIRSETEEE
EIFASWFWAGKE-----NNTEAEQCCESKPKDD-EEMI----------------------
-VESWLWSEDETTEEPETVATCESKLENEERP-LECESRTTDEVNSETDNGANCDNST--
-ESEAIVGSWFWEGDETHFES-NPSPVFRAICKSS-SGEQDPDPSRRPQSWDEVTVKFKP
-GPW----GRLGFPSISPFRFPKAA-ASLFSDMFGGKPKRRRGSS--------------Y
---R--PEPEFPFQYDPSY--------------------RSVQEIREHLKAKERSKPDRW
SCSCVQ-----CDLRIGSEEFEELLILMDRIRDPFVHEISKIAMGMRSASPFTR------
----------DFIRDSGVVSLIEALVDYPSSRD------RT-SFLEDMVDV-APPYPELN
IIQTYVCRVCEDTITKSLDSYEQLSGLTMIRHLTTTTDYHTLVANYMPGY-LTLLETGNA
K-TR-YHVLKVLLNLSENLAMTKELLDTE---VMTEFMGLCNRKDTY----------DNI
EVVLEIFENISKNIEKEAFFADNDI----------DV--EPLI-SKFHDVKKCAKELLSK
------------------------------------------------------------
-------------------------------------------

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-------MTGAEVDTGAQAKAEKKPGEEV--------VG-----------GAEPEREVPL
VVRPKV--------------------------RPQVPVTPGARPKTETKSLSRARPKSET
------QSMAGT------------RPKT----------------------------DIQA
MTGARPKT----------------------------EAPVMTGARPKTD------ARAVG
GARPKT--EAKPIPGTRPKDDA--------------Q--------------VWAQSEFG-
-----PEAMSQAEGALPSNAVTWPLVSARS--ASVPKSKSLSMDRELVSMDSETFPGTQ-
-GHHGLQPWFGLG-EESN------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---MGSWCYPRPRAR-EETSNESGFWSADETSTMSSFWTGEETNIRSWPREEA---NARS
RHRAKHQ-----T--NARYRPRSKQEPYIDT-WSGSE-----------------------
-DEAGSPFCFWSGENTNNLF----------------------------------------
---------------------RPRGREEADIRPKPRAKREDY--FESESE------DEFY
KESWFLPGEEA----------NR-----FRRRDKEEPNNILNPR----------------
NQ----KDVKNSDRAKQDPRF-----EEEVIIGSWFWAEKES------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------SL
EAGAG----ASAICESEPGAE-----GGAI------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------GGSLFWAEEKP
SLGA--------------------------------------------------------
-----------------------------------------------MAREETRPES---
------------------------------------------------------------
------------------------------------------------------------
-EEEAIFGSWFWDRDEACYDL-NPIPVYKANCRFRDPAEEELNASSRPQTWEEVTVEFRP
-GPY-----GVGFPSASSFRIPEGSS-----ENTEAQAKNGEGSPEE----V--EQVSLL
QPNQ--PEPEFSFQYDPSY--------------------RSVQEIREHLKARESAEPENW
SCNCIQ-----CELKIGSVEFEELLLLMDKIRDPFIHEISKIAMGMRTASQFTR------
----------DFIRDSGVVSLIETLLNYPSSRV------RT-SFLENMIHM-APPYPNLN
MIETFICQVCEETLAHGVDSLEQLTGIRMLRHLTMTTDYHTLIANYVSGF-LSLLTTGNA
R-TK-FHVLKMLLNLSDNPMVAKKLFSAK---ALAIFVGLFNVEETN----------DNI
QIVIKMFQNISNIVKSGAMALID---------DDFSL--EPLI-SAFHEFEELAKQLQIQ
IDNQNDPEVEQQS-----------------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------MTGAEIEPGVQAKPEKKPGEEVG--------G-----------GAERENEVPM
VVRPKV--------------------------RTQA--TPGARPKTESKAMAGARPK---
---------------TESKAMVGARPKT----------------------------ESQT
MAGARPKA----------------------------ESQAMAGARLKTE------ARAVG
GARPKT--EAKAIPGARPKDEA--------------Q--------------AWAQTEFG-
-----AEAMSQSEGVSQTNAVTWPLVNTES--GSAAKPMALSVDRELVNVDTETFPGSQ-
-VQTGIQPWFGSG-EETN------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---MGSWCYPRSRAR-EEASNESGFWSADETSTMSSFWAGEEASIRSWPREEA---NTRS
RHRAKHQ-----P--NPRSRPRSKQEPYIDS-WSGSE-----------------------
-EESGNPFCLWAGENTNNLF----------------------------------------
---------------------RPRVRDEANMRSKLRTKREDF--FESESE------DEYY
KESWFLPGEEA---------NSR-----FRPRDKEESNTVLKPR----------------
AQ----KDVNNSDRVKQEPRF-----EEEVIIGSWFWAEKEV------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------SM
EAG------ASAICESEPGAE-----EGAI------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------GGSLFWAEEKS
SLGA--------------------------------------------------------
-----------------------------------------------VAREETRPES---
------------------------------------------------------------
------------------------------------------------------------
-EEEAIFGSWFWDRDEACFDL-NPHPVYKASPRFRDTAEEGVNVSSRPQTWEEVTVEFKP
-GPC----HGIGFPSPSPFRIPEEA-ASVYSEMFEGKPKNVEVTPEG----E--EQESLL
QPDQ--PDPEFPFQYDPSY--------------------RSVREIREHLRTRESAEPESW
SCSCIQ-----CELKIGPEEFEELLLLMDKIRDPFIHEISKIAMGMRTASQFTR------
----------DFIRDSGVVSLIETLLNYPSSRV------RT-SFLENMIHM-APPYPNLN
MIETFICQVCEETLAHSVGSPEQLLGLRMLRHLTTTTDYHTLVANYMSGF-LSLLTTGNA
R-TK-FHVLKMLLNLSENPMVAKKLFSAK---ALSIFVGLFNIEETN----------DNI
QIVIKMFQNISSIIKNGTMSLID---------DDFSL--EPLI-SAFHEFEKLAEELQVQ
IDNQNDPEVGQQS-----------------------------------------------
-------------------------------------------

------------------------------------------------------------
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-----------------------------------------------MGRARE--VGWMA
AGLM----IGAGACYCVYKLTI------------GR--DDSEKLEE------EEEEEWDD
DQELDEEEPDIWFDIETMARPWSEDGDWTEPGAPGGTEDRPSGGGKANRA--HPIKQRPF
PYEHK--------NTWSAQNCKNGSCVLDLSKCLFIQGKLLFAEPKDAGFPFSQ------
----------DINSHLASLSMVRNTGPTPDPTV------R--EALCATDNL-NASIESEG
QIKMYINEVCQETVSHCCNSFLQQAGLNLLISMTVINN---MLAKSVSDLKFPLISEGSG
C-AK-VQVLKPLMGLSEKPVLAGELVGAQ---MLFSFMSLFIRKGNR----------EIL
LETPAP------------------------------------------------------
------------------------------------------------------------
-------------------------------------------

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------------------------------------------------------------
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-------MTRAEVEPGAQAKAENKPGDENA--------N-----------AAEVEPEAPL
VVRPKV--------------------------RT--QIMTGARPKVKPKGTPGARPKG--
------------------------------------------------------------
------------------------------------------------E------TSTPG
GAYAKC--KPKAIPIARSKHDA--------------Q--------------VWAPNKFR-
-----GESMSKMGKQCQISAADPPLLSNDS--GMVAQAKCLPVDRELANMDTESIPKK-A
NSPAGFQPSYGSE-EGTN------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---MGSWYRARPVPK-GEAYENSDFKWADKPSGSPSFWNRDEASTRFRPRKSMKA-NNRF
RHMAKQE-----A--NTMPRHKNKQEFYNIS-SSDSE-----------------------
-DESGKTPWFWPKDKTKVWS--KPKEEP-NSRSWFRSKKEVRV------------ESTSG
SECENPTKSLFWSGEEAKSRSKPRARKGVNMRARQQAKREACSDAMSGAI------DTNK
KESWFLPEEKA---------NVF-----SKSKTKKEPRTRAVPK----------------
EE----VKTKARASTKQEARP-----EEEVLVGAWFWDTQESTMADRISIKT-TFVEEEP
IVGDWFWSEEEASVDSETCHTS-RPRAKEEQVSSFCLGSG-KKSSMESGPKATSKSMPVA
KED-EVVIGSWFWADDEEIN---------------------------------LQADDES
IFGSWFWGTGENS-LRS-VGVNCE-------------------------------KMPK-
A-GEKEVTDSWFWAGD-VNTEAEVEEQ----------ARSASTKATIFVPWFWSEKQPNM
DLG------SEPCSDIMAGAE-----EEPIIGPWFWAKVDNSVEAEVNSKSSLEDEEE-P
IRSPWFGAREQTDMKYAAGIRYKPMAEAEDANKKSCVWAK-EPCLYPTNRECLKSTLGEK
-----EDTVDPWLWSNNYPRTKTITG------------------------SWLWAAEEGN
IDDETGEKIKLPTLEDNAFNSWFWKENEESIVEAPKREEFRPEAEEEDIIGSWFWAGDED
RFEPAAKINEENK-IASEDEDTVGSWFWGNEE----------------------------
---ASLEAVRRGTFESAPGIKEE-----KVTGSWFWTDK-AKVGAGSQT-VETGSETEEE
AIFESLIWAAKK-----DSIQAGVKRVSKPKDD-GNIA----------------------
-VGSWLWSSDKATKEAKTLIVSEASPENGKESVVKFGSRAKDEVINKTGSGDNCKHST--
-EAETIVGAWFWEGDEASFES-NPVPVCKAVCEPESSAEHEPDPSRRPQSWDEVTVQFKA
-GPW----GKAGFPPMNPFRFPKEA-ASLFAEMFGGKPKLVEVGP-E------------R
---E--PEPQFPFQYDPSY--------------------RSVREIREHLKARESAQPENW
SCNCIQ-----CELRIGSEEFEELLLLMDRNRDPFIHEISKIAMGMRGASQFTR------
----------DFIRNSGVVSLIEALLNYPSSRV------RT-RFLENMVRM-APPYPDLN
MIETYVCQICEDTFDYDLDSPDQLSGLTMITHLTATSDYHKVVVNYLAGF-FYLLNSGNT
K-TR-FHVLKLLLNLSENLVMTKRLLVTD---SVSEFMDLINREESD----------ENI
QIVLAIFETISKHIQKEALFSDDDD--DDEEEDAVNL--EPFI-SAFREAEKIAKELKRK
PGNQKAP-----------------------------------------------------
-------------------------------------------

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-------MTGTEF--------EKETGEEVV--------G-----------VAEIENDVPP
VVRPKV--------------------------RTQTQIMTGARPKTKTKVIPGIWSNT--
------------------------------------------------------------
------------------------------------------------D------ARTVG
RVYTKS--KVKMIPGSRSKDDA--------------Q--------------VWALSEFG-
-----TESMSKTDQDSQTNAIISPVVSTES--ELVAKTKCLFIDRELVNKDNESFPGKKV
HSQVGFQPSFGSG-EVTD------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---SETWSFHRPVSSKQEPSQ--------NS-VNSWFWSQEEVNVRFHPRNRVQA-STRY
RHMPKQE-----A--TNYSRHKNKQDLYVVSSSSDSE-----------------------
-DESVKASWFYAKQKTSSLS--RSREEV-NSRSWSK--KEVSV------------EFSSG
SECENAMKSWLWDREKTKCRTLPRARKETNERAQHSHKRDACIDVMCEST------DVIK
KESWFWPEEKG---------KTL-----LRCNTKKEPKVQAMEK----------------
EE----A----RTRIKPEERS-----QGEGLTGTGFWATEKSTLMDMGSIKSSPQLEEES
IVGSWFWTEEEVSMETGPSSKS-RPAVKEELVDSSCLGAG-ERTSMEIGAEATSQSVLAA
SDE-EVIVGSWFWAGEE-VN---------------------------------PESKEET
MFGSWFWSTDEAS-VESGVGVSCE-------------------------------SRPK-
-S-EEEVIGPWLWTGE-VSIEAGVGEE----------FSQGSEEETIFLSWFWSENQTRM
DSV------MEASCDVPGAEE----EEDPVFGSWFWTRVDACEEAAVNSKSSLEHEE--A
IMPSLIVAREEANTKFGVGASCKFKAEAEDTNNKSCFWVKEEPCLYRANRGNWKLRSEEE
-----EDTADSRFWSRKYTRPEAFVG------------------------SWLQAVEDGS
TDCETRQKAMLPTEEKIMTKSQFGKEDKDTTVEATDRKESRPETEEEDIVGSWFWPEEEG
RLEAETEDREESSLGVEE-ESVLGAW--GKQEAI-RESGFCNKYSSKADVEEVIVGSWFW
EQETSLETVTADIFESKTGTEEE----EITVGSWFWPKE-ADREAESQAVDEARSKSEKT
-ILGSCYSARKE-----VSIEAGMCCVPKPAYD-EEMI----------------------
-VESWFWSSDKTIKEIGTVATCESRSQDD-------------------GDGTSCESKTLP
EEEEDIVGSWFWLGDEAHFES-NPNPVFRATCESWGSVEEEPEPSHRPQSWEEVTVQFKP
-GPW----SRVGFPSLNPFRFPREA-APLLSQMFGE-NRNVELNAEG----A--QQASSH
H-----IEPEFSFQYDPSY--------------------RSVQETREHLRAKKSAEPESW
FCSCIQ-----CELRIDSEEFEELLLLMDKIQDPFIHEICKIAMGMRSASRFTR------
----------DFIRESGVVSLIETLLDYPSSRV------KT-RFLKDMILT-APSYPNLN
MIQTFVCQVCEETLAYRKDSPEQLSGLRIIRHLTTTTDYHTLVVNYMSDF-LALLATGNV
R-TR-CHVLEMLLNLSENIVMTKELLSSE---AMSVFMGLFYKEETN----------DNI
EIVLEIFENIGNNFRKETVFTD----------DDFSL--ESLI-PTFHEVEKLAKQLQSK
IDNQNNPEADQQN-----------------------------------------------
-------------------------------------------

------------------------------------------------------------
--------------------------------------------MGRTQEVGWVTAGLVI
WAGTCYYIYKFTKGRAQSVRTLARNGSTV-KMETVVG----VQSQTLAKSEAE----IKT
KPQAEIGAETGTRGGPGAEVETKATAIARHRANSQ----AKTMVEAEAETQSE-------
SKVVAGTLVMTEAVTLTEVK--AKAREVAMKEAVTQTDAEAGKIVKKEAVTQTK-AKAWA
LIAKTEAKREAMTQTKAETHILAEKETEINRVMVTQSETLAVPKE----VVKMGATNKTG
IVDETKTRALEETVSVAKTQSEARPGATVDARGNPNGMSREVAGVDMKSCAQSQAVTKIK
GDDMPGAGIEDMGNCK---------------------------TMSRAESGADTRASAQP
QIVAKTQTEAIPGAKVDAGNNANAMCKVGAGADVRACV-QPQTVVKKQAEVTSGAG-VDG
RGNTNVISKAITGADMRAAAQPQAVASAHAEAMSDAKVKDRGNPNAMTKAGARANLRANS
QVEALPDARDKSRGNPNVIAKAGDGTDMLSCT-QPQLVASVQANTLSDGRIKVKGNVNTM
PKEGAGVDMKAQ--GMAQSQGEALPNTRGKARGKAKAKCKTGSGMDMKTCTQPQTGVKTP
AEALLDSRVDGRGNPNATSKAGTKADQRACGQPLVVANPQGEALPGAKNKVKGNPHAVLK
VGAGEGTADSAQPQAV---------------------------------------VSFQG
EALLGTKNKVKGNPNVVLKAEVGAGAMGTAQLQIEASSKGEALLDSKNTVKGNSNAVSKA
GAGTDTTGSVQPQIVANSQGEVLPGAKNKFRGNSTTVPNSGVGPYT--------------
--------------------------TDSAQPQAVANSQGEVLPGAKNKVKANLNALSKA
EAGMGAT-----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------GSVQSQAVANAHCETLPGAKNK
VRGNWNAVSKAGAGMDTRGSAQTQAVANSQGEVLPGARNKVKGNPNVVSKAGAKEDTMGS
AQPQVVANSQRETLPGARNKVKGNPNVVSK-----AGAKEDTMGSAQPQVVANSQRETLP
GARNKAKGNSNAISKAEAGAGIMGSVQVQVVASSQDEVLPAAKNKVRGN--SNAVPKAEA
GADTVGSAQPQAVANSQSETLLGARNKVKGSTNTVPKAGTGAGTRHSAQPQIVAGSQ---
-------------------------------------GETLPGARDKAMPSSEAETTAED
EVYAKPE--AQAMPISESEGGSGTQACRKTQLNIHDYYWNGIGVEDWIAAERWIKFRFQT
MDGDWENSVSWADDENEASIGSWSGA-SDK--AGIIRSWAVAC----DEASVKSWAGARA
ENEAGIGTWARAG-EQASGGLWAGGQPSEGTWAGD------------KASGGAWTGAENQ
ASGGSWVLAGNQAIGELWAVGQASNVSWPGGQASGVSWVGAEAIGGSWTG--------AE
NQASGGSWAGA------------------------GAGNMSSVSYWAGVVDQASG-GSWA
GT------------SDQSGGGSKPRFEDQASGEGSWAGAGDQASGGSRLGPEDQSSGRSW
ADTANQASGGSRLGHVDQSSGG--------------------------------------
----------SWAGTLDQSGGGSKPIFENQTTEEG-SWAGAGGQAGGGSKVGSEDQSSGR
SWANSGDQISGGFLVGVVDQANGGSWTGA----GHPASGGPKPIFEDQASGRRSWA-DAG
DQVVGDSRLGLRDQSSGDSWAGTGDQASG------------WF-------------CVCP
G---SQ-TNGGSWGGASGQDVGGSRPGPTNQSSAGSWDSPGSQVSGSSWTGAGAVDQVGG
CSKPGFEDQAIGGGFWPGPGDQTGGGSRPGSEDQS--SGIGSWGVAGGQVL---------
------------------------------------GGARP--ADQSSGGSWAGTG---N
QVSGRSWIGPG--NQ-AGDCSKPEFEDQ-ACGGSSWAGAGSQASGESWAGSTPGNE----
---ATGG-----S--RM-----------------GSE-----------------------
--------------------------DQATGGSWARSEDQASGRFQVSVEVEANEGFWFG
PGAEAVIGSWCWTEAKADIVSKPDDKDEATTASRLEAGEEAIICSRTEAE------NKAS
SGSWIRSEEVA--------YMGSCVGAEAEAE------------------AEAEAG--AE
AG----------------AE----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-AE--AEAGARAEAEA-----------------------------GAGAGAEAGAGVWSW
DGDA------------------------TTVESRLGAGEEAGV-----------------
---ESWTLARD------V-GEDELSRESSP-DI-EEIS----------------------
-LRSLFWAESENSNTFRSK--------SGKD--ANFDSGAGDNT-SIEDKFEA-------
-AGGVDIGSWFCDGNENTNED-KSASKAKAKKSSE-S----------RGTYPSM-VPGAG
MGSW----DGAMIWSETK--FP------------HQ--SEASFPVED----E-----SR-
KQ-T-----------------------------------KT------------GEKPRPW
SCRCKR------EANMDPRDLEKLICMIEMTEDPSVHEIANNALYNSADYPYSH------
----------EAVRNVGGISVIESLLNNPYPSV------RQ-KALNALNNI-SVAAENHR
KVKTYLNQVCEDTVTYPLNSNVQLAGLRLIRHLTITSEYQHMVTNYISEF-LRLLTVGSG
E-TK-DHVLGMLLNFSKNPSMTKDLLIAN---APTSLINIFSKKETK----------ENI
LNALSLFENINYHFKRRAKAFTQ--------DK-FSK--NSLY-FLFQRPKACAKKLRAL
AAECNDPEVKERVELLISKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------RGRAGAGTALKAG--------ISSP----
------ANPRAKARIQAKAVG-----EAELETGTV----TQAKAGDGAVARTQTVTCTEA
--VAVTRDVGKM------------------------------------------------
------------------------------------------------------------
-----------ETMTKNRVMTETKAKSVA-EPGIVPQTKSKVMPMARV--SAITKCEVKA
A-----------------------------------------------------------
-------AGSKTAIRSFAKAD-----DKASIESRPER-----------------------
--------KREDDIKFR----------AE-------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------AGDRAGIII-----------------------------ESSDEDEENVCSWFW
TGEE------------------------PSVGSWFWPEEETPSQV---------------
-----YKPPPK---------------------I-QEKP----------------------
------------------------------------------------------------
----------------------KPI--PK----------------------PELTIKQKA
-AAW----SRA--RYSVLVPIE------------GG--EPS-LPP---------EGNWTL
VETLIET--------PLGIRPLTKIPPYKGPYFQTLAE------IKNQVRYREKYGPNPR
ACRCKS-----RDFSLEPKEFDKLVALLKLTKDPFIHEIATMIMGISPAYPFTQ------
----------DIIHDVGITVMIENLVSNPNVTE------HP-RALNMVDDN-SESSEERK
PAESYIHQVCKDIISYPLNSPVQLAGLKLLVHLSVKFEDHHIIANYIPDF-LTLLNNGSV
K-TK-FYVLKVFLRLSKNQANTRELISAK---VLSSLVAPFNKNESK----------ANI
LSIIEIFENINFQFKKKAKLFTK--------EE-FTK--SELI-SIFQEAKEFGQKLQDL
A-EHSDPEVRDKVIRLILKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
---------------------------------MGRVQEVGWVTAG----------LVIW
AGTCYYIYKLT--KGRAQ-SVRRLD----RNGSRARI--DAGSKTSATWKAGAGADMRAC
VQPQTVFKKHAENKVK-DNPNS--VSKAEAGKSTT------SSAQPQVAAGSQGEALAGA
--RTGPVAEAVSVTVA--------PALTEAV------------SATPVVAVAVAPAVAEA
PAI---------------------------AAGPVV---AVA------------------
-----------------PVVAMAP--------------AVAVAPVVA-------------
AAPTIAAAPVVAV-----------------------------------------APAVAA
APAVA----------VAPAVA---VAVAP-------------------------------
------------------------------------------------------------
-----------------------AVPAAPAVAPAPAVAPAV-------------------
-----------AVAPAVAATP---------------------------------------
-VVAPAL-APAPAVAVA------------------------------P------------
------------------AVA-----------------P-AP------------------
----------------------AVAV----------------------------------
----------------APAVAAVPAIGDETGNIPSGGS----------------------
-----------KGNTEVKQGQ-Y----RVGK--------------RNRPEEDDLVWQGKN
GE---------GSCRTAGGSGN------------WGPDLMGDVALT-----ETGVASHSE
GVGVGGEAPSRRRRSV-G---------------------------ER----RITEGKFNF
PYKID--------DILSTPDLQKVLNILERTNDPFIQEVALVTLGNNAAYSFNQ------
----------NAIRELGGVPIIAKLIKTKDPII------RE-KTYNALNNL-SVNAENQG
KIKTYISQVCDDTMVCRLDSAVQMAGLRLLTNMTVTNHYQHLLSYSFPDF-FALLFLGNH
F-TK-IQIMKLIINFTENPAMTRELVSCK---VPSELISLFNKEWDR----------EIL
LNILTLFENINDNIKSEGLASS---------RKEFSR--NSLFF-LFKESGVCVKKIRAL
A-NHSDLVVKVKVLKVLTKL----------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
-------MTGAEIESGAQVKPEKKPGEEVV--------G-----------GAEIENDVPL
VVRPKV--------------------------RTQAQIMPGARPKDKSKVIPGASTKV--
------------------------------------------------------------
------------------------------------------------E------TSAVG
GARPKS--KAKAIPVSRFKEEA--------------Q--------------MWAQPRFG-
-----PERLSKTERNSQTNIIASPLVSTDS--VLVAKTKYLSEDRELVNTDTESFPGRKA
HYQAGFQPFFRSK-EETN------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---MGSWCCPRPTSK-QEVSPNSDFKWVDKSSVSSLFWSGDEVTAKFHPGNRVKD-SARS
RHMANQE-----A--NTMSRSQTNQELYISS-SSGSE-----------------------
-DESVKTPWFWARDKTNTWS--GPREDP-NSRSRFRAKKEVYV------------ESSSG
SEHEDHLESWFGAGEEAKFRCKMRAGKETNNRARHRAKREACIDFMPGSI------DVIK
RESCFWPEENA---------NTF-----SRPMIKKEARARAMAK----------------
EE----AKTKARARAKQEARS-----EEEALIGTWFWATDESSMADEASIESSLQVEDES
IIGSWFWTEEEASMGTGASSKS-RPRTDGEPIGDSLFGTG-EKTSMKTGAEATSECILAA
DDE-QVIIGSWFWAGEE-VN---------------------------------QEAEEET
IFGSWFWVTDAAS-VESGFGVSCE-------------------------------SRSR-
-SEEEEVIGPWFWSGEQVDIEAGIGEE----------ARPGAEEETIFGSWFWAENHTYM
DCR------AEASCGTMQGAE----EEGPIIGSWFWTRVEGCVEGDVNSKSSLEDKEE-A
MI-PCFGAKEKVSMKHGTDVRCRFMAGAEETNNRSCFWAEKEPCMYPTCGGIWKTRPEEE
-----EDIVNSWFWSRKYTKPEAIIG------------------------SWLWATEESN
I-DGTGEEAKLLTEEETMINSWFWKD--EAISEATDREESRPEAEEGDIIGSWFWAGEED
RLEPAAEVREEDRLVAEKE-GIVGSWFGAREETIRREAGSCSKSSPKAEEEEVIIGSWFW
EEEASLEAVAGVGFESKPGTEKE----EITVGSWFWPEEETSIEAGSQAVEEMESETEEE
TIFGSWFWAGKE-----VSEEAGPCCVSKSEDD-EEMI----------------------
-IESWFWSGDKATKETGTVATCESKPENEEGAIVGSWFEAEDEVDNRTDNGSNCESRTLA
DEDEAIVGSWFWAGDEAHFGS-NPSPVFRAICRSTCSVEQEPDPSRRPQSWEEVTVQFKP
-GPW----GRVGFPSISPFRFPKEA-ASLFCEMFGGKPRNVVLSPEG----E--DQESLL
QPDQ--PDPEFPFQYDPSY--------------------RSVQEIREHLRAKESAEPESW
SCSCIQ-----CELKIGSEEFEELLLLMEKIRDPFIHEISKIAMGIRSASQFTR------
----------DFIRDSGVVSLIETLLNYPSSRV------RT-RFLENMIRM-APPYPNLN
MIQTYICKVCEETLAYSLDSPEQLSGIRMIRHLTITTDYHTLVANYMSGF-LSLLATGNT
K-TR-FHILKMLLNLSENLLMTKELLSAE---AVSEFMGLFNREETN----------DNI
QIVLAIFENIGNNIKKET-VFT---------DDDFNL--EPLI-SAFHKVEKFAKELQGK
TDNQNDPEGDQEN-----------------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MGGARDVGWVAAG----------LVLG
AGACYCIYRLT--LGQRR-GRQ-----------RLRP--SR-------------------
------------------------------------------SAE---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------DLT
NGSYD--------DVLNAEQLQKLLYLLESTEDPILIEKALVTVGNNAAFSANQ------
----------AIIRELGGIPIVGNKINYLNQSI------KE-KALNALNNL-SVNVENQI
KIKIYIHQVCEDVFSDPLNSAVQLAGLRLLTNMTVTNDHQHMLSSYINDL-FHLLLTGDG
S-TK-VQVLKLLLNLSENPAMTEGLLSAQ---VDSSFISLYDGQIAK----------EIL
LRVLTLFQNINNCLQLQGCITN---------HPPFPK--GSLFFLLYGE--KCTQKMRAL
A-YHHDADVKEKVLTLMPAF----------------------------------------
-------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
-------MTGAEVETGSQAKSDKKPQEEVV-------VD-----------GVERESEVPL
VVRPKV--------------------------RPQAPATSGARPKTETKSSSRARPKTES
------QSVSGR------------RPKT----------------------------EAQS
MTGARPRL----------------------------EAQVMSGARPKTD------ARAVG
GARPKT--EAKPIPGARPKNDS--------------R--------------AWAQSEFG-
-----AEAMSHAERAPLPNAVTWPLVNSES--TSVTKSKSLSMDREMANMGSETFPSTQ-
-GQSGIEPWFGPR-EEAN------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---MGSWCYPRPRAR-EETSNESGFWSADETSTMSSLWTGQETNIRSWPREEV---NTRS
RHRAKHQ-----A--NTRSKPRSKQDAYIDS-LSGSE-----------------------
-DEAGNPFCFWAGENANDMF----------------------------------------
---------------------RPRGRDEANVRPKIRTKRENY--FED--E------EEFC
KESWLLPGEEA----------NR-----FRGRDKEEPNKTLKNS----------------
DQ----KDVKNDEKVKQESKI-----EEEVIIGSWFWAEQET------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------SL
EAA------ASAICESEPGAE-----EGAI------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------GGSLFWTEEKP
DLGA--------------------------------------------------------
-----------------------------------------------VARDEVRPES---
------------------------------------------------------------
------------------------------------------------------------
-EEEAIFGSWFWDRDEACFDP-NPTPVYTAKSRYRDPE-EDLNLASRPKSWDEVTIEFTP
--PC----HGVGFPFPRPFIIPEGAS-----GNTEEKAKSAELGAEG----E--EQESVV
QRDP--PEPDFPFQYDPSY--------------------RSVREIREHLKARESAQPENW
SCNCIQ-----CELRIGSAEFEELLLLMDRIRDPFIHEISKIAMGMRGASQFTR------
----------DFIRNSGVVSLIEALMNYPSSRA------RT-AFLENMIEM-APPYPDLN
MIETFICQVCEETLSHSVNSPEQLTGMRMLRHLTITTDYHTLIANYISGF-LALLTTGDA
R-TK-FHVLKMLLNLSDNPMVAKKLFSAK---ALSIFVGLFNIEETN----------DNI
QIVIKMFQNISNIVKSGAMSLID---------DDFSL--EPLV-SAFHEFEELAKQLQIQ
IDNQNEPEEGQ-------------------------------------------------
-------------------------------------------

Query Results

"ENSGT00550000074488_0"

ENSGT00550000074488_0