Query Results 

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------------------------------------------------------------
----------------------------------------------------------MS
TKLFTDKKKQVTILRKNFK-----------TLTGFFC---LILKRRQNWYVSVDSVLAAV
LLPLWVIQP----------------------------------------------KYYFY
ELSGNTVTERPRQICPYVIVAFRYREPKTMAPPA-HKSILE--RSENVLMSPWKGKLIVQ
DRMLCDIALWSTYGAMIPTQLPQELDFKYVMKVSSLKKRLPEAAFRKQNYLERKVCFQDL
CFNLY

PF12480 // ENSGT00530000063735_1_Domain_2 (426, 522)

EVELSNRQGENIDKLTECIKNKQ--------------LAIIKCLEDRGFFILLTS
SALLSEPDF--GG-KQMGLHGLHLFHSP------LS-TGVK

ENSGT00530000063735_1_Linker_2_3 (522, 949)

DLKVE---DDISMKLIPIL
PALNCALLETKKSLPEERIHPNTLVK-HFQELYKADRSPSLT-VAPQDRMKDPTFLGK--
-LPSGFDLIP-PAEKCPSESLTQLNSYFSDPSAYILEVSTALDLLAEHPQSPC-VSDGIC
DAGFSLVMTPDPDFPGSEAEVRKETETKKDSEEMLKAKKRVVVPLSP-ASNLRVQP-KRK
ASMPHVV---------------------Q-SKKVNLCHPFPKRTAPRADNSSDSPTTLKL
VKGQFPQKRKR-GAEVLTAQFVQKTKLDRKNQEAP--ISKDVPVPTNAKRARKQEKSPVK
TVPKAKPPVKKSPQKQRVNIVKGNENPRIRKQLQPVKGETASKLQSEISRDGQEDGISI-
NSVQPENTTVA-HNDLPENSIVNYDSQALNMLADLALSSATSS-TPVS

PF12509 // ENSGT00530000063735_1_Domain_3 (949, 1125)

EPRNL----HCS
SELPQN-DVLLS-KENSLRSTSDHEYHRGVKSQKGELLPNPSSD------RKSNSETDLI
VSQDEESLVLCSQ---------APAKAQSALTEEMLES---S--DASQSSSVSVEHSYAL
LLREHSKKNL--QEREIPSPVFPKNGTKSPEAVTPVGKVMPFRH

ENSGT00530000063735_1_Linker_3_4 (1125, 1287)

QPGLLLQQKPPDEPMV
KPKDRQASSRVKKSSC-SRIVFSCDDSVKITFKCETEYAFSLDSKYTNNPLEKTVVRALH
GPWNTDLPDNVEEVKLLLHMWVALFYSNQNKVIRSSRKVVEHSNPAKYVSINSTLESCEL
SEI-EECLGLERCS----ADPLLETN

PF12509 // ENSGT00530000063735_1_Domain_4 (1287, 1583)

EISRAHAAEVSFRDPNCLLPFIKTPLTQGLELCV
QNEQKKTFARKRH-PDTLENQDF-VCSYNNE---VIGEEAKQESFDKLKTSNLA-LSGIG
STRTNGPSVPNEEEIVQPLDSTRV-----------------ASYSGTVTQTTF-----TR
TYDGTGSQPV--------------------------------------------------
--------------------------------------------------------ICQS
------SVCSTLE-----NKAD

ENSGT00530000063735_1_Linker_4_5 (1583, 1664)

VPDAAMQT------KTGTLQDLIQHGSPIN-NECHPSL
ERK-DDNMECAMINPEPVTL----------------------I

PF12480 // ENSGT00530000063735_1_Domain_5 (1664, 1717)

FEKNAHVPLQT------
EAVNTADEPTTFNKELIKQVSPAASLRHPVSTSEKAQTQ-------GLRDISSLVVAGQK
GSKYLCASSVGRETLD-KEMCSLQKEMPL-PV-SLPSDKAMVMEALSLV-----KSSSYL
LPSEEVRCTQNFLSQTQSLLSLSSEGLVEPTQVEV-DSSAASTALG--KQCSLNCISSGC
HTSGDSLELRKNDKNGPNTENMNFEEFDSVFI-KQRRLAVSR-EVSLEL--SEEDSDIDL
ALTISPPTSPREEMPAGEIEQFEEA-PFSNLELQDVAEEIG-EPE-------EVAVTESR
EVNSADSASVYPTVSEE-------------------------------------------
-PVENKERKGDNLQPVTVILSKENCTLEIAEEINVTSDFPF-DSVIEEVSPASSPEPPVP
VKETRPY-----QAVTPCILKLHGTQCEKSNRISQRVSEDLGITE-------KENFFVG-
PTHPVGQDNFTQVQQMQVSAEMPLIL-TDHPGRTG--RPTL---PGKVTEDIVSS-----
---------------------------------------EHDE-----GLSFSGKVQCY-
GRE-LN---------------------------QPAS-A---AEYTGDF---SPS-EK--
----LVKSGNPLQPIRVENRNLDLKHLVLE-SSAPPFSPRNVTENMSLSDTLVSTAVPSG
I----VK-------------------QQTSPKSSQNNLLTSDLKT------DEGVYLQVK
SLTTASVDGAYST-QGCMCSVVPTLCSSSDSA-TLTHYVRPINAEPAFQAQEIPAVRMAS
LLKNGETEAELHKEITGLGPAGPQSNTKSSLKGECKAIHTLQDVSTCETKELL-------
--------NVGVSS----LCAS--PYQNTADTRENLS-KEPLASFVSESF-DTS----VC
GISTEHIEIENGGEGLRAQ--AGSETLGRDAEVSG----NSDMHYELLSGDSDLD-LLGD
CRN-AKCDLEDS-CTLRGSYTRKKEDVPTDGCESSLNF----HN-HQGDWGCSS--QVPG
MEMSLPPGHWT--TR----VKKEEKCVPPYVQIRDLHGILRTYANFSVTKELKDTMRTS-
HSLRRHPSFTANCDLPSSWTSTWQ-VADDLTQNTLDLEYLRFAHKLKQTIKN-GDSQHSA
SSTNVFPKELPTQISIGAFPLTKISEASIL-HPAPRSRSPLLVTVVESDPR---PQG-QP
RRGYTASNLDN---SSSWRERCSHN--RD-LTHSQ-RSQTVSFHLNKLKYNS--TLKESR
NDISLILNEYAEFNKVMKNSNQVVFQ-DKELNDA-SGEAT-AQVMYLPFPGRSISFEDII
IDLCSNLHIKLRSVVKEACKSTFLFYLVETE-DKSFFVRTKNLLRKGGHTEIEPQHFCQA
FHREDD--TLIIIIRNEDISSHLHQIPSLLKLKHFPSVIFAGVDSPGDVLDHTYQELFRA
GGFVITDDKILEAVTLVQLKEIIKILEKLNG--NGKWKWLLHYRENKKLKEDERVDSTAH
KKNMMLKSFQSANIIELLHYHQCDSRSSTKAEILKCLLNLQIQHIEARFAVFLTDKPTI-
-PREVFENSGILVTDVNNFIE---------NIEKVAAPFRTSYW----------------
-----------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------MAPPA-HKSILE--CSENVLMSPWKGKLIVQ
DRMLCDIALWSTYGAMIPTQLPQELDFKYVMKVSSLKKRLPEAAFRKQNYLEQKVCFQDL
CFNLYEVELSNRQGENIDKLTECIKNKQ--------------L-----------------
---------------------------------------VKDLKVE---DDISMKVIPIL
PALNCALLETKKSLPEERIHPNTLVKHHFQELYKADRSPSLT-VAPQDRMKDPTFLGK--
-LPSGFDLIP-PAEKCPSESLTQLNSYFSDPSAYILEVSTALDLLAEHPQSPC-VSDGIC
DAGFSLVMTPDPEFLVSEAEVRKETETKKDSEEMLKAKKR-VVPLSP-ASNMRVQP-KRK
ASMPHVV---------------------Q-SKKVNLCRPFPKRTASRADNSLDSPTTLKL
VKGQFPQKRKR-GAEVLTAQFVQKTKLDRKNQEAP--ISKDAPVPTNAKRARKQEKSSVK
TVPRAKPPVKKSPQKQRVNIVKGNENPRNRKQLQPVKGETASKLQSEVSRDGQEDGISI-
NSVQPENTTAA-HNDLPENSIVNYDSQALNML

PF12509 // ENSGT00530000063735_1_Domain_3 (933, 1126)

ADLALSSATSS-TPVSEPRNL----HCS
SELPQN--VLLS-KENSLRGTSDHEYHRGVKSQKGELLPNPSSD------RKSNSGSDLT
VSQDEESLVPCSQ---------APAKAQSALSEEMLES---S--DASQSSSVSVEHSYAL
LLTEHSKKHL--QEREIPSPLFLKNGTKSPEAATPVGKVMPFRHQ

ENSGT00530000063735_1_Linker_3_4 (1126, 1251)

PGLLLQQKPPDEPMV
KPKDRPMSSRVKKSSC-SRIVFSCDDSIKITFKCETEYAFSLDSKYTNNPLEKTVVRALH
GPWNTDLPDNVEEVKLLLHMWVALFYSNQDKVIRSSRKVVEHSNPAKYVS

PF12509 // ENSGT00530000063735_1_Domain_4 (1251, 1582)

INSTLESCEL
REI-EESLGLERCS----ADPLLETNEISRAHAAEVSFHDPNCLLPFIKTPLTRGLELCV
QNEQKKTFARECD-PDTQENQNS-VCSYNNE---VIGEEAKQE---SLETSNLV-LSGIG
STQTNGPSVPSEEEIVQPLDSTRV-----------------ASYSGTVTQAAF-----TR
TYDGPGSQPV--------------------------------------------------
--------------------------------------------------------ICQS
------SVYSTLE-----NKV

ENSGT00530000063735_1_Linker_4_5 (1582, 1609)

DVLDAAMQT------KTGTLQDLIQHG

PF12480 // ENSGT00530000063735_1_Domain_5 (1609, 1718)

SPIN-NECHPSL
ERK-DDNMGCAMINPESVTL----------------------NFEKNAHVSIQT------
EGVNTADEPTAFNKELIKQVSPAASLRHPVSTSEDAQTE-------GLRDIPSLVVAGQK
GTKYLCASSVGRETLD-KEMCSLQKQMPL-PI-SLPSDKTVVMEALSLV-----KSSSYL
LPSEEVRCTQDFLSQTQSLLSLSSEGLLEPTQVEV-DSSSASTTLG--KQWSLNCISSGC
HTSGDSLELRKNDKNGPNTENMNLEAFDSVFI-KQTSLSVSR-EVSLEL--SEEDSDIDL
ALTISPPTSPREEMPAGEIEQFEEA-PFSNLELQDVAEEIG-EPE-------EVALTESR
EVNSADSVSVYPSVSEE-------------------------------------------
-PVENKERKGDNLQPVTLILSKENCTLEIAEEINVTSDFPF-DSVIEEVSPASSPEPPVP
VKETRPY-----QAVTPCILKLHGTQCEKSNRISQCESEDLRITE-------KEKVFVG-
PTHPVGQDNFTQVQQMQVSAEMPLIV-TDHPGRTG--RPTL---PGKVTEEIVSS-----
---------------------------------------EHDE-----GLSFSGKVQCY-
GRE-LN---------------------------QPAL-A---AKCTGDF---SPSPEK--
----LVKSGNPLQPVSIENRNLDLKHLVLE-SSEPPFGPRNVIENKSLSDTLVSTTAASG
IVNVSVK-------------------QQTSPKSSQNNLFPGDLKT------DEGIYLQVK
SLTAASVDGAYST-QGCMCSVVPTLCSSSDNA-TLTHYLRPINAEPAFQAQEIAAVRTAS
LLKNGETEAESHKETTGLGTAGPQSHTTCSLKGERKAVHTPQDVPACETKELL-------
--------NVGVSS----LCAG--PYQNTVDTRENLS-KEPLASFVSESF-DTS----VC
GIATEHVEIENSGEGLRAE--AGSETLGRDAEVSV----NSDMHYEL-SGDSDLD-LLGD
GRN-PKFDLEDS-YTLRGSYTRK-KDVPTDGYELSLNF----HNNNQEDWGCSS--RVPG
TETSLPPGHWT--TA----VKKEEKCVPPYVQIRDLHGILRTYANFSITKELKDTMRTS-
HSLRRHPSFTANCGLLSSWTSTWQ-VADDLTQNTLDLEYLRFAHKLKQTIKN-GDSQHSA
SSANVFPKESPTQISIGAFPSTKISEAPFL-HPAPRSRSPLLVTVVESDPR---PQG-QP
RRGYTASSLDS---SSSWRERCSHN--RD-LTNSQ-RNHTVSFHLNKLKYNS--TVKESR
NDISLILNEYAEFNKVMKDSNQFIFQ-DKELNDV-SGEAT-AQEMYLPFPGRSASYEDII
IDVCTNLHVKLRSVVKEACKSTFLFYLVETE-DKSFFVRTKNLLRKGGHTEIEPQHFCEA
FHREND--TLLIIIRNEDISSHLHQIPSLLKLKHFPSVIFAGVDSPGDVLDHTYQELFRA
GGFVISDDKILEAITLVQLKEIIKILEKLNG--NGRWKWLLHYRENRKLKEDERVDSTAH
KKNIMLKSFQSANIIELLHYHQCDSRSSTKAEILKCLLNLQIQHIDARFAVLLTDK-TI-
-PREVFENSGIHVTDVNN-IE---------NIEKIAAPFRSSYW----------------
-----------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------MSPWKGKLIVQ
DRMLCDIALWSTYGAMIPTQLPQELDFKYVMKVSSLKKRLPEAAFRKQNYLERKVCFQDL
CF

PF12480 // ENSGT00530000063735_1_Domain_2 (423, 525)

NLYEVELSNRQGENIDKLTECIKNKQ--------------LAIIKCLEDRGFFILLTS
SALLSEPDF--GG-KQMGLHGLHLFHSP------LS-TGVKDLK

ENSGT00530000063735_1_Linker_2_3 (525, 933)

VE---DDISMKLIPIL
PALNCALLETKKSLPEERIHPNTLVK-HFQELYKADRSPSLT-VAPQDRMKDPTFLGK--
-LPSGFDLIP-PAEKCPSEALSQLNSYFSDPSAYILEVSTALDLLAEHPQSPC-VSDGIC
DAGFSLVMTPDPDFPGSEAEVRKETETKKDSEEMLKAKKRVVVPLSP-ASNLRVQP-KRK
ASMPHVV---------------------Q-SKKVHLCHPFPKRTAPRADNSSDSPTTLKL
VKGQFPQKRKR-GAEVLTAQFVQKTKLDRKNQEAP--ISKDVPVPTNAKRARKQEKSPVK
TVPKAKPPVKKSPQKQRVNIVKGNENPRIRKQLQPVKGETASKLQSEISRDGQEDGISI-
NSVQPENTTVA-HNDLPENSIVNYDSQALNML

PF12509 // ENSGT00530000063735_1_Domain_3 (933, 1126)

ADLALSSATSS-TPVSEPRNL----RCS
SELPQN-DVLLS-KENSLRGTSDHEYHRGVKSQKGELLPNPSSD------RKSNAESDLI
VSQDEEGLVPCSQ---------APAKAQSALTEEMLES---S--DASQSSSVSVEHSYAL
LLREHSKKNL--QEREIPSPVFPKNGTKSPEAVTPVGKVMPFRHQ

ENSGT00530000063735_1_Linker_3_4 (1126, 1251)

PGLLLQQKPPDEPMV
KPKDRQASSRVKKSSC-SRIVFSCDDSVKITFKCETEYAFSLDSKYTNNPLEKTVVRALH
GPWNTDLPDNVEEVKLLLHMWVALFYSNQNKVIRSSRKVVEHSNPAKYVS

PF12509 // ENSGT00530000063735_1_Domain_4 (1251, 1584)

INSTLESCEL
SEI-EECLGLERCS----ADPLLETNEISRAHAAEVSFRDPNCLLPFIKTPLTQGLELCV
QNEQKKTSASKCH-PDTLENQNF-VCSYNNE---VIGEEAKQESLDKLETSNLV-LSCIG
STRTNGPSVPNEEEIVQPLDSTRV-----------------ASYSGTVTQTTF-----TR
TYDGTGSQPV--------------------------------------------------
--------------------------------------------------------ICQS
------SVCSTLE-----NKVDV

ENSGT00530000063735_1_Linker_4_5 (1584, 1609)

PDSAMQT------KTGTLQDLIQHG

PF12480 // ENSGT00530000063735_1_Domain_5 (1609, 1719)

SPIN-NECHPSL
ERK-DDNMECAMINPAPVTL----------------------IFEKNAHVPLQT------
EAVNTADEPTTFNKELIKQVSPAASLRHPVSTSEKAQTQ-------GLRDISSLVVAGQK
GSKNLCASSVGRETLD-KEECSLQKEMPL-PV-SLPSDKAMVMEALSLV-----KSSSYL
LPSEEVRCTQNFLSQTQSLLSLSSEGLVEPTQVEV-DSSSASTALG--KQCSLNCISSGC
HTSGDSLELRKNDKNGPNTENMNFEEFDSVFI-KQRRLSVSR-EVSLEL--SEEDSDIDL
ALTISPPTSPREEMPAGEIEQFEEA-PFSNLELQDVAEEIG-EPE-------EVAVTESR
EVNSVDSVSVYPTVSEE-------------------------------------------
-PVENKERKGDNLQPVTVILSKENCTLEIAEEINVTSDFPF-DSVIEEVSPASSPEPPVP
VKETRPY-----QAVTPCVLKLHGTQCEKSNRISQRVSEDLGITE-------KENFFVG-
PTHPVGQDNFTQVQQMQVSAEMPLIL-TDHPGRTG--RPTL---PGKVTEEIVSS-----
---------------------------------------EHDE-----GLSFSGKVQCY-
GRE-LN---------------------------QPAS-A---AEYTGDF---SPSPEK--
----LVKSGNPLQPIRVENRNLDLKHLVLE-SSEPPFSPRNVTENMSLSDTLVSTAAPSG
V----VK-------------------QQTSPKSSRNSLFTSDLKT------DEGIYLQVK
SLTTASVDGAYST-QECTCSVVPTLCSSSDSA-TLTHYVRPINAEPAFQAQEIPAVRMAS
LLKNGETEAELHKEITGLGTAGPQSNTKSSLKGERKAIHTLQDVSTCETKELL-------
--------NVGVSS----LCAS--PYQNTADTRENLS-KEPLASFVSESF-DTS----VC
GISTEHIEIENSGEGLRAQ--AGSETLGRDTEVSG----NSDMHYELLSGDSDLD-LLGD
CRN-PKCDLEDS-CTLRGSYTRKKEDVPTDGCESSLNF----RN-NQGDWGCSS--QVPG
MEMSLPPGHWT--TR----VKKEEKCVPPYVQIRDLHGILRTYANFSVTKELKDTMRTS-
HSLRRHPSFTANCDLPSSWTSTWQ-VADDLTQNTLDLEYLRFAHKLKQTIKN-GDSQHSA
SSASVFPKELPTQMSIGAFPLTTISEASIL-HPAPRSRSPLLVTVVESDPR---PQG-QP
RRGYTASNLDN---SSSWRERGSHN--RD-LTNSQ-RNQTVSFHLNKLKYNS--TLKESR
NDISLILNEYAEFNKVMKNSNQVIFQ-DKELNDA-SGEAT-AQVMYLPFPGRSISFEDII
IDLCTNLHIKLRSVVKEACKSTFLFYLVETE-DKSFFVRTKNLLRKGGHTEIEPQHFCQA
FHREDD--TLIIIIRNEDISSHLHQIPSLLKLKHFPSVIFAGVDSPGDVLDHTYQELFRA
GGFVITDDKILEAVTLVQLKEIIKILEKLNG--NGKWKWLLHYRENKKLKEDERVDSTAH
KKNIMLKSFQSANIIELLHYHQCDSRSSTKAEILKCLLNLQIQHIEARFAVFLTDKPTI-
-PREIFENSGILVTDVNNFIE---------NIEKVAAPFRTSYW----------------
-----------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------MAAPT-SKIILEL--NKNALVSPWKGQFMIQ
GCLLCDITLWSTHGTVIPVQLPRELDFKYVMSVSSLKESLPEAAFRRRNYLEQKVCCQDL
CFDLY

PF12480 // ENSGT00530000063735_1_Domain_2 (426, 522)

EVELTNKQGENIDKLMEYVKNKE--------------LALIKCLEDKSFFILLTS
SALTPEPGF--GA-EQMGLHGLHLFHAP------QT-AGAK

ENSGT00530000063735_1_Linker_2_3 (522, 949)

DLKVE---DGVSLKVIPIL
PALSYALLEAKKSLSEEGISPNILVKHSFQELYKVDKSLSLM-APPQDGVKDTASTGK--
-LPHAFDLPP-PLETCPSESLTHLKCYFSDPAGYTLDLSAALDLLAEHPQFPC-ISDGVC
DAGFSLVMTPDPEFLDSEMEIRKETETAEKCGRKLKVKKKAVTP----SSNQRVQP-KRK
ASTTAVT---------------------LPSKRVSLGRPTSKRTVPRTDSRS-CNPTLKL
VKGQFPQKRKR-GAEVLAAQIVQKTRLERKKQEV--SVSKDAPVPANAKRAKKQEKSPGR
IASQPKPPVKKSPQKRKVNVARGRRNT--RKQLQPAEKEIALHLQSEISSDGQKDGLYL-
STSQQESIAMI-PKGPPENSVISCDSQALNMLADLALSSAASS-IPSC

PF12509 // ENSGT00530000063735_1_Domain_3 (949, 1130)

KPRNL----PCF
SDLPGN-SVLLT-KENPLLGASDHEYHKGVKSQKAVLLPKPYSD------EKISSESDIT
RSQE-ENLVPCAQ---------PLATAQPAPHAEAREL---S--DASQNS-VVVEHSYAL
LLAEQSQKHL--HQRKLPSPAFVKNGIKGPEPGTPVGKVMPFRHLQNTSPLQKHSEDSLM
KHKSLFVSSTLKEFFC-SHTVLKCDGSFKITFKCEGEYVFSLDSKYTSNPLEKTVLRALH
GPWNTDLPENVDDVKLLLHIWVALFYSKKNKVIGSPRKVVEHKNPAKYVCINRPLESLDH
SEI-EAFSNVERPSVEGSVDPLLETKETHIGHATNMTFPGPNRVLPFINPPTTRDLELCV
QNDQKEVFTGECH-LDTSGNQNFIY-SCNTE---VTGGKTKQELSDKLETSNAV-LSGVV
SAQSNGTCIPSEDKTCQS---TKM-----------------VSYNDSVTQATL-----TT
AYDEASSELMCQKSVFDDLENKVDS-----------------------------------
------------------------------------------------------------
-----------------------VHPSPLI------KTDAVQDVIQHSSHIN-NECQPSV
ERM-EDNVECMMVNLDPVTL----------------------AFEKNASVPIHT------
-EVHTTDKPTGFNIELVKQVSPASSVQYPMSALEEVQTQ-------SSRDVPSLAMSEYK
DSKCLSASSVKKETLP-ESLCLLQKEIPS-LTSSA--DEGLIMEALSLV-----KSSSYS
LASDKTKCPQDTSLQTQNGLSMSLDEVLEPSKVKV-VS-STSVTLR--EQQSPNCIPAMS
DVAGTSTVIMNSGSSSLNQEK-ILQTFNLVFP-KQTDLSLNREEVSMEL--SGEGADINL
TLTISPPISPGEGIAAGEIEQFQRT-PVSNVGQQSRS-EMVEPEE-------EERLIKNR
EIHSASCMSVYPVESRE-------------------------------------------
-LLK-------------------NCTPEVTEKVNVTLDFPF-GPLIE-VSPASSPDPIVQ
TGDRQSS---------PCCLELHSSQSEKTNKLSQIKSGEVTIPE-------KESLLLG-
PESPKGQDKLAEVQ-VQISAEMLQIT---SAEVEG--RVNV---PGKVTKVSVPS-----
---------------------------------------EHSE-----NLSFLEKVQCN-
-A-ELN---------------------------KLSL-P---AKYGGNF---K-PLEK--
-------SGNSLEPGCMENRNMDIKHLALE-SSVPLCSPRKVVENKSLTDTLVSIT-TSE
IVNMSLK-------------------Q-TSSKNIKKNVCDSDVKT------EADSNMQAE
AVNSASIEKTDVQ--AYSHPEVSKFVSSSDSA-QCTYHTKPVSVEPGFQTQEIPVVRMAS
LLKNIG--AELHEERMDLSATGLQSNSMS-TKDEQKTMHVVQDT-ICEVKEFL-------
--------NGDVFS----QNAQ-NVCQNTVDFSKSIS-EEPSASFVPEFV-DA-----IC
GVYKEHTFSESPNMVHETK--ADAETLSRNTEISI----NASMCCGPRSGACVQD-SR-D
CKS-CKFDVEN----LRGNRKSQ-KDAVKDSCESFTSL----NNSD-DTWACSS--KIST
LETHIPPRNQE--TEPRL-ISPN-KCIPRYIQIPDSHGIPKTYANFTITKEFKDTTRRL-
HSLKRHRNLSANCNLLSSWISTWH-VTDDLTQNTLDLEYLRFDHKLKQTKK--GDSQH--
---SSFPKESLVQTSVGTSPSTQTSEASGL-HLPPENRCPILVTVVRADTR---QQS-HH
RRGYSPSSLDS--SSSFWKKKCSQS--RN-LKNSE-RSQTVPFHLNKLKYNS--TLKESR
NDISLILNEYAEFNKIMMNSNQIVSQ-DEELNVA-SAEAV-FQE--AYQPRQTVSYEDVI
TDLCATLHVKLKGVAREACKSPFWFYLVETE-DKSFFLRTKSILKKGGHIEIELLDFCQA
FHRENE--TLLVIIKNEDIISHLHQIPSLLKLKHFPSVVFAGVDSPEDIINDTYQELFRS
GGFVVSDDVILESLTLVQLKEILKILEKLNE--NGKWKWLLHYRESKNLKEDVRVDSIAH
KKNLILKSYQSVNIIDLLHYHNCDSPSSTKAEIFKCLLNLQIQHISARFAVFLTDKPTV-
-STEIFENNGILVTDVNYFTE---------NIQKIAAPFRSSYW----------------
-----------------------------------------

-------------------------------------------------MFLPFRPIIYD
INREQEYVKNSGGILGENELRPPSQLHPLLEKTETGFIS-------EKIFETVSLSSDSL
FQRTVSILHTSYLDSASEHGFQYSEVTLVKNDIFL

PF12509 // ENSGT00530000063735_1_Domain_0 (156, 316)

NEYKAFYQEKKASNYTHEELQETYG
FLLFETENQAKLVCQHGLCVGSSAITTLGDPAKGVYISKYSDYLHARPWYHGKSGYV---
---VIFNLIKGKVKFVSENYTANYTSPSSGYDCHVAANINKISHKTSHFRTFELSQYYLY
ELSGSTVTERPRQIC

ENSGT00530000063735_1_Linker_0_2 (316, 423)

PYLIVAFQYREPKKMAAPA-HDHKSILELKENVLISPWKGKLIIQ
GCLLCDITLWSSYGTVVPKQLPHELDFKYVMKVSSLKERLPEAAFKKQNYMEHKVCCQDM
CF

PF12480 // ENSGT00530000063735_1_Domain_2 (423, 517)

SMYEVELSNKQGEKVDKLIEYIKREQ--------------LAIIKCLEDREFFILLTS
SALMSETGF--RE-EQTGLHGLHLFHSP------PSAAGLTDLKVE---DDISLKVVSVL
PALNCALLEAKKSFSEKGISLNTLVKHNFQDLSKVNKSPPVT-AASQDGFKETGFSGQ--
-VSSGFDLTP-PAEKCPLQSLTQLKSYFSDASGYILGVSTVLGLLAERPQSPC-ISDGIC
DAGFSLVMTPDPEFRDSEAEGRKDTETGNNSEDVFQARQGALVPLSL-APNLRVQP-KRK
ASTLPMV---------------------Q-SKRVSLYRPFPKRTPAGENKGPTSTTTLKL
VKGQFPQRRKR-GAEVLTAQFVQITKLDRKPQEAP--SSKDVPVATNAKRARRRAASPDT
PVPTAKPPMKKSPQKQRVNIVKGNQNPRLRKQPQPAKGETALQLQSEISSG--QDVISI-
NTTQPEHVTVA-PKAPTETSVVGCDSQALNMLADLALSAATSS-TPSPEPRNL----PCS
LEPPQN-SVPLS-KEQPLCGTSDHEYHRGVKSQRGGPLHKPSSD-------QSSPSSDPT
VSPEEESMGPGSW---------APAEAQPALPKETHES---S--DASQSSFVAAEHSYAL
LLVEHSK-------RGSPGLAFAKSSTKGSDIGTPVGKVIPFLRQNLTSPLQKLSMALAF
RHRAGLLSTGPHDFRCSSHTVFCCDGSFKVMFTCEADYSFSLDSKYTNNPLEKTVVRALH
GPWNTDLPDNVEEVKLLLHMWVALFYSRQNKVVRSSRKVVEHSNPAKYVSINSTLEPFEC
-EI-EEPSGVERYS----VDPLLEASEAPRAHAAEVSCPGADPLHPFTKSPPVRGLELWV
QNEQKEMFATVGH-QESPESQNFI-C-YNNE---IIRGKAEQESSGKLETSDLV-LPSIG
RTQANGPSIPGEDETFEPLDNTQV-----------------TSYNDTASQTTF-----AK
TYDEINSPSM--------------------------------------------------
--------------------------------------------------------ICQK
------SVYSTLE-----SKVDIFHAQKET------EADALQGLTQCS

PF12480 // ENSGT00530000063735_1_Domain_5 (1609, 1717)

SPIN-KECQPLL
EGK-G-DTGYVMINLEPVTL----------------------TLEKSAYVPVQT------
EAVSRADKPTAFNMELTKQVSPAASLRHPVSTFEKSQMQ-------GLGEDPSLAVSGQK
GTQYLHASSVHRETLA-EETYSLQKGQAA-TGSPSPSDNPMVIEALPLA-----KSSNYL
LPREEMKLSQEFLLPTQNLLSISSEEIIEPSQVEV-VPLSASAPLG--KKDSLNCIASIR
NTLCGSSEL-KKDKSGLNSENISFKPFNSTFT-KEAGLSVNREEVSLKV--SEEDSNLDL
TLTLSPPMSLREEAPTGEVEQPQEA-SLPCVDLQEMAEEIL-MSK-------EVTFIENR
DVNSAANTSV------K-------------------------------------------
-PAENKEGKGDHLQTVAFILSKETCTRQVAEEVHLASDFPF-GSLIEEVSPASSPGPQAP
VEEAPPT-----QATSPRGLKHRDTLGEKSTRLCEVESGDLAETE-------KESSLVT-
ATHPVEQDNSAQVQQMQLSAETPLQL-QNHAGRKGR-FLIL---PGDVTEETGPS-----
---------------------------------------KCGE-----GFSLSGKGPDC-
DA-TVT---------------------------QPAC-G---VTYGD-------SLEN--
----LVSSGYPLQPTGVEICRPHSHHRVLE--TSEPFSPAEIPENKSSADMFVSTATPGA
VVT--------------------------STQSLPEDVLSSNVKT------QECCYILVK
SLRSDPVAGAEGV-QTHGHPELPKPALPSGRA-TTANSTGPSDTGTGFPTQEVPVVRMTH
LLNSEDSGAELQGRAADPGGAGPQLLTTS-PQGRQESACLLQEGSPCAVWDLL-------
--------HGGLLP----TYLQADAHPGTAAHGESAS-PEPSVSFAPRSG-APP----VG
GVSEEQLQGVSTGEA----------GTGGGKGVGV----ISDIYYEPLSGDSDQD-SVGE
YGH-PRYNTEES-RASQYGHTGKREGASKDSYDAFLSL----NTSDDHDWGYAS--QVPG
LETSVPPRSWL--GG----LKKEATCVPCYVQIRDVCGVPRSYANFTVTRELRDTPRTL-
HGLRRRPSSTVPCGLLSSWVDTWQ-GTDDLTQNTLDLEHLRFAHKLKQIVKM-GAARHSA
LLPGAFPKEPPPQVTTGAFPGTPMPTCPGL-PPTSRSRSPLVVTVVHQMPN---------
-------HVDR---SSSWKKGCGHG--RNHLTNSD-QNQTASFHLHKLKYNS--TLKDSR
NDIAVILSEYAEFNKVMLSSRQL-VQ-DTEPPVA-LGAAM-PSELCVCSP-QPASYEDLV
ADLCSSLRVKLERVVREACSSTFLFHLVETE-DKSFFVRTKNILRKGGHTEIEPQHFCQV
FHREKG--ALLVIIRNEDIASHLHQIPSLLKLKHFPRVVFAGVDSPEDVLNDTYQELFQT
GGFVVSDDKLLETLTLVQLKEIVKILEKLNE--NGRWKWLLHYRENKKLKEDVRVDSIAH
KKNLILKSYQSANIIELLHYHQCDSRPSTKTEHLKCLVNLQVQHIHARFAVFLTEKPVV-
-SREVFENSGILVTDVNDFIE---------NIQKVAAPFRSSYW----------------
-----------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------MAPPA-HKSILE--RSENVLMSPWKGKLIVQ
DRMLCDIALWSTYGAMIPTQLPQELDFKYVMQVSSLKKRLPEAAFRKQNYLEEKVCFQDL
CFNLY

PF12480 // ENSGT00530000063735_1_Domain_2 (426, 522)

EVELSNRQGENIDKLTECIKNKQ--------------LAIIKCLEDRGFFILLTS
SALLSEPDF--GS-KQMGLHGLHLFHSP------LS-TGVK

ENSGT00530000063735_1_Linker_2_3 (522, 949)

DLKVE---DDISMKVIPIL
PTLNCALLETKKSLPEERIHPNTLVKRHFQELYKADRSPSLS-VAPQDRMKDPTFLGK--
-LPSGFDLIP-PAEKCPSESLTQLNSYFSDPSAYILEVSSALDLLAEHPQSPC-VSDGIC
DAGFSLVMTPDPEFLVSEAEVRKETETKKDSEEMLKAKKR-VFPLSP-ASNLRVQP-KRK
ASMPHTV---------------------Q-SKKVNLCRPFPKRTASRADNSSDSPTTLKL
VKGQFPQKRKR-GAEVLTAQFVQKTKLDRKNQEAP--ISKDVPVPTNAKRARKQEKSPVK
TVPRAKPPVKKCPQKQRVNIVKGNENPRNRKQLQPVKGETASKLQSEISRDGQEDGISI-
NSVQPENTTAA-HNDLPENSIVNYDSQALNMLADLALSSATSS-TPVS

PF12509 // ENSGT00530000063735_1_Domain_3 (949, 1122)

EARNL----HCS
SELPQN-DVLLS-KENSLRGTSDHEYHRGVKSQKGELLPNPSSD------RKSNSGSDLT
VSQDEESLVPCSQ---------APAKAQSALTEEMLES---S--DASQSSSVSVEHSYAL
LLREHSKKHL--QEREILSPLFPRNGTKSPEAATPVGKVMP

ENSGT00530000063735_1_Linker_3_4 (1122, 1287)

FWHQPGLLLQQKPPDDPVV
KPKDRPTSARVKKSSC-SRIVFSCDDSVKITFKCETEYAFSLDSKYTNNPLEKTVVRALH
GPWNTDLPDNVEEVKLLLHMWVALFYSNQNKVIRSSRKVVEHSNPAKYVSINSTLESCEL
REI-EESLGLEKCS----ADPLLETN

PF12509 // ENSGT00530000063735_1_Domain_4 (1287, 1583)

EISRGHAAEVSFRDPNCLLPFIKTPLTQGLELCV
QNEQKKAFARECD-PDTQEDQNF-ICSYNNE---VIGEEAKQE---SLETSNLV-LSGIG
STQTNGPSVPSEEEIVQPLDSTRV-----------------ASYSGTVTQATF-----TR
TYDGPGSQPV--------------------------------------------------
--------------------------------------------------------ICQS
------SVYGTLE-----NKVDVLDAAMQT------KTGTLQDLIQHGSRIN-NECHPSL
ERK-DDNMGCAVINPEPVTL----------------------TFEKNAHVPIQT------
EGVNTADEPTTFNKELIKQVSPAASLRHPVSTSENAQTQ-------GLRDIPSLVVAGQK
GTKYLCASSVGRETLD-KEMCSLQKEMPL-PV-SLPSDKTMVMEALSLV-----KSSSYL
LPSEEVRCTQDFLSQTQSLLSLSSEGLLELTQVEV-DSSSASTTLG--KQCSLNCISSGC
HTSGDSLELRKNHKNGPNTENMNLEAFDSVFI-KQTSLSVSR-EVSLEL--SEEDSDIDL
ALTISPPTSPREEMPAGEIEQFEEA-PFSNLELQDVAEEIG-EPE-------EVALTESR
EVNSADNVSVYPSVSEE-------------------------------------------
-PVENKERKGDNLQPVTLILSKENCTLEIAEEINVTSDFPF-DSVIEEVSPASSPEPPVP
VKETRPY-----QAVTPCILKLHGTQCEKSNQISQCESEDLGITE-------KENVFVG-
PTHPVGQDNFTQVQQMQVSAEMPLIL-THHPGRTG--RPTL---PGKVTEEIVSS-----
---------------------------------------EHDE-----GLSFSGKVQCY-
GRE-LN---------------------------QPGS-A---AKCTGDF---SPSPEK--
----LVKSGNPLQPVSIENRNLDLKHLVLE-SSEPPFGPRNVIENKSLSDTLVSTTAPSG
IVNVSVK-------------------QQTSPKSSQNHLFPGDLKT------DEGIYLQVK
SLTAASVDGAYST-QGCMCSVVPTLCSSSDNA-TLTHYVRRISAEPAFQAQEIPAGRRAS
LLKNGEPEAELHKETTGPGTAGPQSNTTSSLKGERKAIHTLQDVSTCETKELL-------
--------NVGVSS----LCAG--PYQNTADTKENLS-KEPLASFVSESF-DTS----VC
GIATEHVEIENSGEGLRAE--AGSETLGRDGEVSV----NSDMHYEL-SGDSDLD-LLGD
CRN-PKFDLEDS-YTLRGSYTRK-KDVPTDGYESSSNF----HNNNQEDWGCSS--WVPG
METSLPPGHWT--AA----VKKEEKCVPPYVQIRDLHGILRTYANFSITKELKDTMRTS-
HSLRRHPSVTANCGLPSSWTSTWQ-VADDLTQNTLDLEYLRFAHKLKQTIKN-GDSQHSA
SSANVFPKESPTQISIGAFPSTKISEAPFL-HPAPRSRSPLLVTVVESDPR---PQG-QP
RRGYTASSLDS---SSSWRERCSHN--RD-LRNSQ-RNHTVSFHLNKLKYNS--TVKESR
NDISLILNEYAEFNKVMKNSNQFIFQ-DKELNDV-SGEAT-AQEMYLPFPGRSASYEDII
IDVCTNLHVKLGSVVKEACKSTFLFYLVETE-DKSFFLRTKNLLRKGGHTEIEPQHFCQA
FHREND--TLIIIIRNEDISSHLHQIPCLLKLKHFPSVIFAGVDSPGDVLDHTYQELFRA
GGFVISDDKILEAVTLAQLKEIIKILEKLNG--NGRWKWLLHYRENKKLKEDERVDSTAH
KKNIMLKSFQSANIIELLHYHQCDSRSSTKAEILKCLLNLQIQHIDARFAVLLTDKPTI-
-PREVFENSGILVTDVNNFIE---------NIEKIAAPFRSSYW----------------
-----------------------------------------

-------------------------------------------------MFLPFRPIIYD
INREQEYVKNSGGILAENELRPPSQLHPLLEKTETGFIS-------EKIFETVSLSSDSL
FQRTVSILHTSYLDSASEHGFQYSEVTLVKNDIFLNEYKAFYQ

PF12509 // ENSGT00530000063735_1_Domain_0 (164, 316)

EKKASNYTHEELQETYG
FLLFETENQAKLVCQHGLCVGSSAITTLGDPAKGVYISKYSDYLHARPWYHGKSGYV---
---VIFNLIKGKVKFVSENYTANYTSPSSGYDCHVAANINKISHKTSHFRTFELSQYYLY
ELSGSTVTERPRQIC

ENSGT00530000063735_1_Linker_0_2 (316, 426)

PYLIVAFQYREPKKMAAPA-HDHKSILELKENVLISPWKGKLIIQ
GCLLCDIALWSSYGTVVPKQLPHELDFKYVMKVSSLKERLPEAAFKKQNYMEHKVCCQDM
CFSMY

PF12480 // ENSGT00530000063735_1_Domain_2 (426, 517)

EVELSNKQGEKVDKLIEYIKREQ--------------LAIIKCLEDREFFILLTS
SALMSETGF--RE-EQTGLHGLHLFHSP------PS

ENSGT00530000063735_1_Linker_2_3 (517, 949)

AAGLTDLKVE---DDISLKVVPVL
PALNCALLEAKKSFSEKGISLNTLVKHNFQDLSKVNKSPPVT-AASQDGFKETGFSGQ--
-VSSGFDLTP-PAEKCPLQSLTQLKSYFSDASGYILGVSTVLGLLAERPQSPC-ISDGIC
DAGFSLVMTPDPEFRDSEAEGRKDTETGNNSEDVFQARQGALVPLSL-APNLRVQP-KRK
ASTLPMV---------------------Q-SKRVSLYRPFPKRTPAGESKGPASTTTLKL
VKGQFPQRRKR-GAEVLTAQFVQITKLDRKPQEAP--SSKDVPVATNAKRARRRAASPDT
PVPTAKPPMKRSPQKQRVNIVKGNQNPRLRKQPQPAKGETALQLQSEISSG--QDVISI-
NTAQPEHVTVA-PKAPTETSVVGCDSQALNMLADLALSAATSS-TPSP

PF12509 // ENSGT00530000063735_1_Domain_3 (949, 1130)

EPRNL----PCS
LEPPQN-SVPLS-KEQPLCGTSDHEYHRGVKSQRGGPLPKPSSD-------QSSPSSDPT
VSPEEESMGPGSW---------APAEAQPALPKETHES---S--DASQSSFVAAEHSYAL
LLAEHSK-------RGSPGLAFAKSSTKGSDIGTPVGKVIPFLRQNLTS

ENSGT00530000063735_1_Linker_3_4 (1130, 1287)

PLQKLSMALAF
RHRARLLSTGPHDFRCSSHTVFCCDGSFKVMFTCEADYSFSLDSKYTNNPLEKTVVRALH
GPWNTDLPDNVEEVKLLLHMWVALFYSRQNKVVRSSRKVVEHSNPAKYVSINSTLESFEF
GEI-EEPSGVERYS----VDPLLEAS

PF12509 // ENSGT00530000063735_1_Domain_4 (1287, 1582)

EAPRAHAAEVSCPGADPLRPFTKSPPVRGLELWV
QNEQKEMFATVGH-QESPESQNFI-C-YNNE---IIRGKAEQESSGKLETSDLV-LPSIG
RTQANGPSIPGEDETFEPLDNTQV-----------------TSYNDTAPQTTF-----AK
TYDEINSPSM--------------------------------------------------
--------------------------------------------------------ICQK
------SVYSTLE-----SKV

ENSGT00530000063735_1_Linker_4_5 (1582, 1663)

DIFHAQKET------EADALQGLTQCSSPIN-KECQPLL
EGK-G-DTGYVMINLEPVTL----------------------

PF12480 // ENSGT00530000063735_1_Domain_5 (1663, 1717)

TLEKSAYMPVQT------
EAVNRADKPSAFNMELTKQVSPAASLRHPVSTFEKSQMQ-------GLGEDPSLAVSGQK
GTQYLHASSVHRETLA-EETYSLQKGQAV-TGSPSPSDNPMVIEALPLA-----KSSNYL
LPREEMKLSQEFLLPTQNLLSISSEEIIEPSQVEV-VPSSASAPLG--KKDSLDCIASVR
NTLCGSSEL-KKDKSGLNSENISFQSFNSTFT-KEAGLSVNREEVSLKV--SEEDSNLDL
TLTLSPPMSLREEAPTGEVEQPQEA-PLPCVDLQEMAEEIL-MSK-------EVPFVENR
DMNSAANTSV------K-------------------------------------------
-PAENKEGKSDHLQTVAFILSKETCTLQVAEEVHLASDFPF-GSLIEEVSPASSPGPQAP
VEEAPPA-----QATSPRGLKHCDALGEKSTRLCEVESGDLAKTE-------KESSLVT-
ATHPVEQDNSAQVQQMQLSAETPLQL-QNHAGRKGR-FLIL---PGDITEETGPS-----
---------------------------------------KCGE-----GFSLSGKGPDC-
DA-TVT---------------------------QPAC-G---VTYGD-------SLEN--
----LVSSGYPLQPTGVETCSPHSHHRVLE--TSEPFSPAEIPENKSSADMFVSTATPGA
VVT--------------------------STQSLPEDVLSSNVKT------QECCYILVK
SLRSDPVAGAEGV-QTHGQPELPKPALPSGRA-TTANSTGPSDTGTGFPTQEVPVVRMTH
LLDSEDSGAELQGRAVDPGRAGPQLLTTS-PQGRHESACLLQEGSPCAVWDLL-------
--------HGGLLP----TYLQADAHPGTAAHGESAS-PEPSVSFAPRSG-APP----VG
GVSEEQLQGVSAGEA----------GTGGGMGVGV----TSDIYYEPLSGDSDQD-SLGE
CGH-PRYNTEES-RASQYGHTGKREGASKDGYDAFLSL----NTSDDHDWGYAS--QVPG
LETSVPPRSWL--GG----LKKEATCVPCYVQIRDVCGVPRSYANFTVTRELRDTPRTL-
HGLRRRPSSTVPCGLLSSWVDTWQ-GTDDLTQNTLDLEHLRFAHKLKQIVKM-GAARHSA
LSPGAFPKEPPPQVTTGAFPGTPMPTCPGL-PATSRSRSPLVVTVVHQMPN---------
-------HVDR---SSSWKKGCGHG--RNHLTNSD-QNQTASFHLHKLKYNS--TLKDSR
NDIAVILSEYAEFNKVMLSSRQL-VQ-DTEPPVA-LGAAM-PSELCVCSP-QPASYEDLV
ADLCSSLRVKLERVVREACSSTFLFHLVETE-DKSFFVRTKNILRKGGHTEIEPQHFCQV
FHREKG--ALLVIIRNEDIASHLHQIPSLLKLKHFPRVVFAGVDSPEDVLNDTYQELFQT
GGFVVSDDKLLETLTLVQLKEIVKILEKLNG--NGRWKWLLHYRENKKLKEDVRVDSIAH
KKNLILKSYQSANIIELLHYHQCDSRPSTKTEHLKCLVNLQVQHIHARFAVFLTEKPVV-
-SREVFENSGILVTDVNDFIE---------NIQKVAAPFRSSY-----------------
-----------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------MAAPA-RESILE--LSENVLRSPWKGKLTIQ
GCMLCDISLWPTYGTVLPTQLPQELDFKYVIKVSSLKKRLPEAAFRKQNYLEQKVCCQGL
CFNLY

PF12480 // ENSGT00530000063735_1_Domain_2 (426, 522)

EVELSNRQGEKIGKLTEYIKKNQ--------------LAIIKCLEDRGVFILLTS
SALISESDF--GA-EQMGLHGLHLFHSP------PS-AGVK

ENSGT00530000063735_1_Linker_2_3 (522, 949)

DLKVE---DDISMKVIPIL
PTLNCALREAKKSLPEEATHPNTSVKRHFQELCKVDRSTPLT-AAAQGGIKETAFFGK--
-LSGGFDWAP-PAEKCPSESLTQLKSYFADPSGYIFEVSTALDLLAEPPQSPC-VSDGVC
DAGFSLVMTPDPELLDSEAEVRKETETKKKSEEILKAKKAVVVPMSR-ASSLRVQP-KRK
ASMPPVV---------------------Q-SKKVNLCRPLPKRTAPRADNGLDSPTTLKL
VKGQFPQKRKR-GAEVLTAQFVQKTKLDRKSQEGP--ISKEVPVTTNAKRTRKQEKSPVK
TVARAKPPVKKSPQKQRVNVVRGHQKPRLRKQPQPAKRETASRLPSEISSAGQEDGISI-
NTVLPENATVA-HKDLPENSIVNYDSQALNMLADLALSSATSS-TPAS

PF12509 // ENSGT00530000063735_1_Domain_3 (949, 1130)

EPRNL----PCS
SELPEN-DVLLS-KENSLRGTSDHVYHRGVKSQKGGLLPKPSSD------KKSNSGSDLT
ISKDEESLVPYSQ---------APAKAQSALTEEKTDP---S--DASQSTFVSVEHSYAL
HLAEHSKRHL--QQRGIPGPAFAKNGTKGPEAGTPVGKVMPFRHQQSVS

ENSGT00530000063735_1_Linker_3_4 (1130, 1289)

PLQKLPEDPLM
KRKSRLMSSSLKDFLF-SHTVFSCDGSFKVTFKCETEYAFSLDSKYTNNPLEKTVVRALH
GPWNTNLPDNVEEVKLLLHMWVALFYSSQNKVLRSSRKVVEHSNPAKYVSINSTFDSYEL
NEP-EDSPCVERCS----ADPLSEPSEA

PF12509 // ENSGT00530000063735_1_Domain_4 (1289, 1583)

SRGPAAQVAFPDPHCLLPLIKPTPTRALALSM
QNEQEEIFARECH-LDTPENQTFLF-SCNNE---VIREKAKEDSSDKLETSNLV-LSGIG
STETNRPSIPGEDETLQLLDSTRV-----------------ASYNGTVTQATF-----TA
TYNGISSQPV--------------------------------------------------
--------------------------------------------------------MRQK
------SVYSTLE-----NKVDILHAQVQT------KSGAFQDLLQHGSPIS-SECQPSF
EGK-DDSMGYVMINLEPVTF----------------------TFDKNAYVPVQT------
EVVNRADKPTTFNKELIKQVSPAANLRHPVSTLEMAPTR-------GLRDIPSLAVSGQK
GTQYLCVSSAGREMLD-KETCSLQKEVPL-PA-SSPSDGAAVMEALSLV-----RGSGYP
VPSEEMKLSQDFLLQTQSLCGISSEEVAEPTRVDV-DSSSASATLE--KACSLNCTVSRS
GTSDSSLGLSKHARSDLNSEIANFESFNSVFI-KQTSLSVDREEVSLEL--SEEDSDIDL
TLTISPPTSPREEMPAGEMEQIQEG-PSSNL--EDTAEETV-EPE-------ELPLTENR
EVNSAGYVSVYPAVS-E-------------------------------------------
-PVENKKTKGDNLQPVTLILSKENCTLEIAEEINVTSDFPF-NSLIEEVSPASSPDAPVP
VEETRPL-----QAVSPCALRLHGTQYAKSNGFPHFESGDVGIAE-------KENSFVS-
PTRPVGQDNLTQVQQMQFSAEMPLML-TNHPGRKG--RLTL---PGNVTEEVVPG-----
---------------------------------------ECEE-----SLSFSEKMQCC-
GAELLN---------------------------QPAL-A---AEYRGDF---KLSLEK--
----PVKSGNPFQPKSIENRNLDLKHLVLG-SSELPFNPRKVIE-KSLG-----------
---------------------------------IKNNLFNRDVKT------HEGSYLQSK
SLNPASVDVAFAT-QAHMHSEIPALGSSSDRA-PLTHYIRPLNVEPGFQTQEISVVKMAS
LLKNSETEAKLYEETVDPGTVDPQSNATS-SKCEQEAIHMLQDVSQCVTKELM-------
--------NGGIFP----MCAG--SCQDTADFSDNIN-KEPSASFVAEPF-EPP----AC
GVSKEHVDPERSGEGLGAE--AGSETLARDAEVGM----NSDMHYEPLSADSDLE-PLGD
CGD-PKLDVEDS-CTFRGGHARRK-DAAEDDYDSLMNS----HGSDHKDWSCSN--RVPG
EERDLPPRHWA--SG----LKKEDKCVPYYIQIPDLQGIPRTYTNFTITKEFKDTTRTL-
HRLKRHPNFTANCGLLSSWTSTWQ-VADDLTQNTLDLEYLRFAHKVKETVKD-GDAQPPA
SSASVFARESPLQIALGPFPLTKTCEAPVL-RPMCRSRSPLLVTVVHSDPR----QG-QH
GRGPTPGNLDS---FS----PCGHG--RH-LSCSP-RNHAASFHLNKLKYNSNSTLKESR
NDISLILSEYAEFNKVMMNSSQAVFQ-DKELNVA-SGEAMGPREMYLSCPRQSASYEDMI
TDLCTNLHVKLKSVMKEACKSTFLFYLVETE-DKSFFVRTKNILRKGGHTDIEPEHFCQA
FHREDD--TLIIIIRNEDIASHLHQIPSLLKLKHFPSVIFAGVDSPGDVLNHTYQELFRA
GGFVISDDEILEALTLVQLKEIVKILDKLNG--NGRWKWLLHYRENKKLKEDVRVDSTAH
KKNIILKSYQSANIIELLHYHQCDSRSSTKADILKCLINLQIQHIDARFAVFLTDKPTI-
-SREVFENSGILVTDVNNFIE---------NIQEVAAPFRSSYW----------------
-----------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-------------------------MFIAFGYSLFTQYKTFYQQ

PF12509 // ENSGT00530000063735_1_Domain_0 (165, 316)

KKANNYTQEELQNTYG
FLLFDTEKQAKLVCQCGLRVGSSAVTTLGDPAKGVYISKYSDYLHPRPWYHGKSGYI---
---VIFSLIKGKVKFVSENYTTNYTKPSSGYDCHVAENTNKVSNKTSHFRAFELSQCYFY
ELSGNTVTERPRQIC

ENSGT00530000063735_1_Linker_0_2 (316, 426)

PYIIVAFRYMEAKTMAPPA-HKSILE--CSENVLMSPWKGKLIIQ
DRMLCDIALWSTYGAVIPTQLPQELDFKYVMKVSSLKKRLPEAAFRKQNYLKQKVCFQDL
CFNLY

PF12480 // ENSGT00530000063735_1_Domain_2 (426, 522)

EVELSNRQGENIDKLTECIKNKQ--------------LAIIKCLEDRGFFILLTS
SALLSEPDF--GG-KQMGLHGLHLFHSP------LS-AGVK

ENSGT00530000063735_1_Linker_2_3 (522, 949)

DLKVE---DDISVKVIPIL
PALNCALLETKKSLPEERIHPNTLVKHHFQELYKVDRSPSLT-VAPRERMKDPTFLGK--
-LPSGFDLIP-PAEKCPLESLTELHSYFSDPSAYILEVSTALDLLAEHPQSPS-VSDGIC
DAGFSLVMTPDPEFLDSEAEVRKETETRKNSEEVLKAKKRVVVPLSP-LSNLRVQP-KRK
ASMPHVV---------------------Q-SRKMNLCRPFPKRTAPRADNSPDSPTTLKL
VKGQFPQKRKR-------------------------------------------------
-----------------------------------VKGETVSKLQSEISRDGQEDGISI-
NNVQSENTTVA-HNDLSENSIVNYDSQALNMLADLALSSATPS-TPVS

PF12509 // ENSGT00530000063735_1_Domain_3 (949, 1125)

EPRNL----HCS
SELPQN-DILLS-KENSLLGTSDHEYHRGVKSQKGGLLPNPSSD------RKSNSGSDLT
VSQNEESLVTCSQ---------TPPKAQSALTEETLES---S--DASQSSSVSVEHSYAL
LLTEELKKHL--QEKETPSPPFPKNGTKSSEAVTPVGKVMPFRH

ENSGT00530000063735_1_Linker_3_4 (1125, 1288)

QPGLLLQPKLSDEPVV
KHKDRPKSSSAKESSC-SHIVFSCDDSVKITFKCETEYAFSLDSKYTNHPLEKTVVRALH
GPWNTDLPDNVEEVKLLLHMWVALFYSNQNKVIPSSRKVVEHSNPAKFVSINSMLESCEL
SEI-EESLGLERCS----ADPLLETNE

PF12509 // ENSGT00530000063735_1_Domain_4 (1288, 1584)

ISRCHAAEVSFHDPNCLLPFIKTPPTRGLELCV
QNKQKKTFARECH-PVIQENQNF-ICSYNNE---VIGEEAKQESSDKLETSNLV-LSSIG
TTQTNGPSVPSEEEIFQPLDSTRV-----------------PSYSGTVTQATF-----TR
TYDGTGSQPV--------------------------------------------------
--------------------------------------------------------MCQS
------SVYSTLE-----NKVDVLDAPIQT------KTDALQDCIQHSSPIN-SECQPSL
ERK-YDNMEYVMINLEPVTL----------------------PFEKKAYVPVQT------
EVVNTADEPTTFNNELIKQVSPAASLRHPVSTLDKTQTQ-------GLRDIPSLVVAGQK
GTKYLCASSVGRETLN-KEMCSLQKEMPL-PV-SLPSDKAMVMEALSLV-----KSSSYP
LPSEEVRCTQDFLSQTRSLLGLSSEGLLELTQVEV-DSSSPFPSLG--KQCSLNRISSGC
YTPGDFLELRKNDKNGPNIEKMNFKAFDSVFI-KQTNLSLNR-EISLEL--PEEDSDIDL
ALTISPPTSPGEEMPAGETEQLQEP-PFSNLEHQDIAEEIG-KPE-------EVALIESR
EVNS-DHESVYPAVSEE-------------------------------------------
-PVENKDRKGDNLQPVTLILSKENCTLEIAEEINVTSDFPF-DPLIEEVSPASSPDPPVP
VKETRPY-----QAVTPCILKLHGTQCEKSNRVSQRKSEDLGITE-------KENVFVG-
PTHPVGQDNFTQVQQMQVSAEMPLII-TDHPGRKG--RPTL---PGKVTEEIVSS-----
---------------------------------------EHDK-----DLSFSGKVQCC-
GRE-LN---------------------------QPAS-A---AEYRGDF---SPTPEK--
----LVKSGNLLQPISVENRNLDLKHLVLE-SSEPPFGPRNVTENKSLSSTLVSTAAPSV
TVNVSVK-------------------QQASSKSSQKNLFSSDLKA------DEGIYPQVK
SLKAASVDRAYSA-QGCMCSVVPRLGSSSDSG-TLTHYVRPINAEPGFQAQEIPAVRMAS
LLKNGETEAELPEETTGLGTDGPQSNTT-SLKGECETMHTLPSVSTCETKELL-------
--------NVGVFS----LCAG--LYQNTADTRENLS-KEPSASFVSESF-DTS----VC
GVSTEHIEIENSEEGLKAE--AGSEILGRDAEVSV----NSDMHYELLSGDSDLD-LLGD
RRN-PKLNLEDS-YALRGSYTRRKKDVATDGYESSLKI----HNNNQEDWGCSS--RVPG
METSLPPRHWT--TG----IKKEEKCVPHYVQIRDVHGILRTYANFSITKELKDTTRTS-
HSLRRHPSFTASCGLLSSRTSTWQ-VADDLTQNTLDLEYLRFAHKLKQTIKN-GDSQHSA
SSTSVFPKELPTQSSTGAFPLTKISEAPIL-HPAPRSRSPLLITVVESDPR---PQG-QP
RRGHTASNLDS---SSSWRERCSHN--RD-LTNSQ-RNQTVSFHLNKLKYNS--TLKESR
N-ISLILNEYAEFNKVMMNSNQTVFQ-DKELNDA-SGEAT-AQEMYLPFPGRSASYEDMI
TDLCTSLHVKLRSVTKEACKSTFLFYIVQTE-DKSFFVRTKNLLRKGGHTEIEPQHFCQA
FHRENE--TLIVIIRNEDISSHLHQIPSLLKLKHLPNVVFAGVDSPGDVLDHTYQELFRA
GGFVISDDKILEALTLVQLKEIIKILEKLNG--NGRWKWLLHYRESKKLKEDERVDSTAH
KKNIILKSFQSANIIELLHYHHCDSRSSTKAEVLKCLLNLQIQHINARFAVFLTDKPTI-
-PREIFENSGILVTDAKNFIE---------NIQKVAAPFRSSYW----------------
-----------------------------------------

-------------------------------------------------------MSIYD
INKGQNCVKDSEGIYGENELRPPSQLHSLLEKIETGFIS-------EKIFKKVSLNSNSV
FQRAVSLLHTSYLDSASEPGFQYSQVTLVKNDIFLN

PF12509 // ENSGT00530000063735_1_Domain_0 (157, 316)

EYRNFYQQKKASNYTPEELQETYG
FLLFETENQAKLVCQRGLCVGSSSITTLGDPSKGVYVSKYSDYLHPRPWYHGKSGYI---
---VIFNLIKGKVKFVSENYTTNYTRPSSGYDCHVAADTNKVSHKTSHFRAFELSQYYLY
ELSGSTVTKRPRQLC

ENSGT00530000063735_1_Linker_0_2 (316, 423)

PYVIVAFKYREPKMMAASV-HKSIPE--LTENVLVPPWKGKLIIG
GYMLCDITLRSTYGMVIPTQLPPELDFKYVMKVSSLKKRLPEAAFKKQNYLTQKVCCQDL
CF

PF12480 // ENSGT00530000063735_1_Domain_2 (423, 515)

SLYDVELSNRQGEKIDKLIEYIKNKQ--------------LAIIKCLDDRGFFILLTS
SALISESDF--GG-EQIGVIGLHLGHSS------

ENSGT00530000063735_1_Linker_2_3 (515, 933)

LS-TEVKDLKVE---DDILLKVIPIL
PALNCALLEAKKSLPEEGIHPNTLVKQNFQELCMEDRRPSLT-AAPQDGIRETALFGK--
-PSDGFDLVP-PAEKCPLESLNLLKSYFSDPSGYILEISTALDLLAEDSQSTC-ISDGIC
DAGFSLVMTPDPEFLDSEAEVRKDNETENNSKERLKAKQGTVVPLSP-VSNLRVQP-KRK
ASMLPVV---------------------P-SKRVNLCCPFPKRSVLGAGSGSQSPTTLKL
VKGQFPQKRKR-GAEVLTAQFVQKTKLNRKNQEAP--ISKDVPVSTNAKRARKQEKSPVK
TVLRNKTSMKKSLHKQRVNIVKGYQNPRIRKQPQS--DDIGIYLESQVSSDGPKDAINV-
NTVQPENTTVD-QKDLTENSIMNYDSQALNML

PF12509 // ENSGT00530000063735_1_Domain_3 (933, 1126)

ADLALRSATSS-TPSAEPRNL----PCT
-ELLQN-DVVLP-KESTLRGTSDHEYHRGIKSQKGGLLVKPSSD------KKSNSGSDLT
VSQDEENLVSCSQ---------APAKVQSALTVETSAP---S--DASQNTFVAVEHSYAL
LLAEHSKKYL--HQRGIPGPAFAKNGTKGPDAGTPVGKVMPFRHQ

ENSGT00530000063735_1_Linker_3_4 (1126, 1251)

QNISPLQKLSEDPLI
KRKSRLMSSNLKNVYY-SHNVFSCDGSLKVTFKCEAEYAFSLDSKYTNNPLEKTVVRALH
GPWNTDLPDNVEEVKLLLHMWVALFYSNQNKVIRSSRKVVEHSNPAKYVS

PF12509 // ENSGT00530000063735_1_Domain_4 (1251, 1581)

INSTLESFEL
SEI-EEFPKVERCS----ADPLLETKETSKGYATEVSFPDHNCLLPFIKSPPVKGLELCV
QNEQKEIFAGKCH-LDTSESQNFIY-SCNSE---VIGEKTKQESSAKSETSKLM-LSDIG
NAQINGLSVPSKDKTFQQLDSTTL-----------------VPYNDTVTQVPF-----TT
TYSETSNQSV--------------------------------------------------
--------------------------------------------------------MCQK
------SVCSTLE-----SK

ENSGT00530000063735_1_Linker_4_5 (1581, 1609)

VDIFHAQMQT------NTGALQDHIHRR

PF12480 // ENSGT00530000063735_1_Domain_5 (1609, 1717)

SPIS-NEWQPSL
ERT-D-DTGYVMINLEPVTL----------------------TFDKNAYVPVQT------
EVVNRGDKPVTFNTELIKQVSPTTSIGHPVSTVEKSQIQ-------SLGGIPPLAMSGQK
GANYLSASLVTNGTLA-EETYSLQKEIPLT-I-SSPSDNAVVMKTL-LG-----KGSSYP
LADDKMKQSQELFMQTQNLFSICSEEIVEPSQVEV-VSPSASITLE--KKYSLNCIPSKI
NTSDDSFELRKNDKSGINNENMHFESFNSIFATKQTSLSPNREEVSVEL--SEEDSDIDL
TLTISPPSSPRKEMPSDENEQLEDV-PLSNIELQDVVEEIA-EPE-------EVTLMENR
PVNS-----VYPAMSKK-------------------------------------------
-LL------------------EKNCTLEIAEEV-ITSDFRF-DSLIEEVSPASSPDPPVS
IEETRPT-----QTVSPCSLILYGTQCEKSNKFSQIVSGDLAITE-------KENSLIG-
PNYTERQGNFTQVQQIQLSADTPQAL-NNHPGRKD--RLAL---PGKVTEEIVPT-----
---------------------------------------EQDE-----GLSFSEEVQCY-
DT-KLN---------------------------QPAS-T---GQNEGNV---KPSLEK--
----LVKSGNSLQPISIENRHLDLKHLVLE-SSEPPFSPRKINENKSLADTLVSTATLSD
IMNMPIK-------------------QQTSPKSIKKNFFHSDLKT------EYGSSSKAN
LLNSDSIDGTDA-----VHLEIPKLGPPSDGT-TLTHYALPVSVEPGFRTQEISVVRMAS
LL-NSETEAELHEENTDLHVASPQSDSTS-TKNEQK-ICMLQ-NTSWETKELL-------
--------NGELFP----KDAG--PYQKTADTSKDIN-KEPSAFSIPKSF-DSL----VC
EISKEHVESNSTTEGCRAE--ADSETLDRDRQSSV----NSDIYYEALSEDHD-------
-----ELDVEDS-YTLSGSHTRK-KDATKGGFDTFMKV----NNNDNEGWSYFN--KVPE
LETSIPPRSWA--IS----LNKEDKCVPCYIQIRDLHGIPRTYPNFTITKELKNTTGTL-
HSPRRQPGLTAHCGLPSIWRHRWH-VPDDLTQNTLDLEYLRFAHKLKQIVKN-GDSQRS-
TPTSIFPKESPTQIVNGTLSLTNVSEVPIL-RPTSKNRSPLLVTIVHSDAR---QQS-QP
LRGRSPRNLDS---SLPWKERSSYS--RN-LTNSQ-RNQTVSFHLNKLKYNS--ALKESR
NDISLILNEYAEFNKLVMNNNPVVFQ-DKDLNAD-SGETT-PQEMCTSSPRRSASFEDMI
TDLCTSLHVKLKSVVKEACKSTFLFYLVETE-DKSFSLRTKNILRKGGHTEIEPQHFCQA
FQREDD--TLIVIIRNEDISSHLHQIPSLLQLKHLPSVVFAGVDSPEDVTDYTYQELFRT
GGFVISDDKILETLTLDQLKEIVKTLEKLNG--NGRWKWLLHYRENKKLKEIVRVDSVAH
KKNLILKSYQGANIIELLHYHRCDSQSSTKTEILKCLISLQIQHIDARFAVFLTDRPTV-
-SREVFENSGILVTDVNDFIE---------NIQKIASPFRSSYW----------------
-----------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------MATPA-HKSIHE--DNKNVLMSPWKGKLTVQ
NCVLCDITLWSNNGAVIPAQLPHILDFEYVIQVSSLREKLPEAALRKQTYSEERVCSQDL
CFNLYEA

PF12480 // ENSGT00530000063735_1_Domain_2 (428, 522)

ELSNKQGKEVDKLIYYVENKQ--------------LAIIKCLEDRGFVILLPS
SALITEPDN--GD-EQMSLQVLHLFRSP------LA-TEVK

ENSGT00530000063735_1_Linker_2_3 (522, 949)

VLKIE---DDILWKVVPIL
PALNCALLEAKKLLPEEGPHPNTLVMHNFQELYKVNKSLSLT-ATPQDGKKETAIFGK--
-LSSSFDLVP-PPEKCPMESLTRLKSYFSDPSGYTLEVSAALDLLAEHPPSPY-ISDGIC
DAGFSLVMTPDPEFLDSEVEIKKKTQMEKNCEEMFKAKKAAVVPLSA-ASNLRVQP-KRK
ASTLPTV---------------------P-SKRVNLCRPFAKRTTPGADSGSYSPPTLKL
VKGQFPQKRKR-GAEVLTAQFVQKTKLNRKNQEVP--ISKDVPVATNAKRARRQEKSPVK
TVPRAKPPLKKSPQKRRVNVVKGIENPRIRKQLQPAKEETALQLQSEISSDGQKDGISI-
STAQPQSTTVA-QKDLPENAIVNYDSQALNMLADLALSSAASS-KPLC

PF12509 // ENSGT00530000063735_1_Domain_3 (949, 1130)

EARDL----PCS
SELPEN-DVLLS-KESSPSGTSDHEYHRGVKSQKGVLLPRSSCD------QKNNSGSDLT
VSQEEENLVPYSQ---------TSATAQSALHKQTFEP---P--GASQYTLIIVEHSYAL
LLGEHSKKHL--QQRGLPGPAFAKNGTKGPDTGTPVGKVMPFRHLQNTS

ENSGT00530000063735_1_Linker_3_4 (1130, 1288)

PLQKLSEDSWV
KRRGRFVSSNLKNVFC-SHTVVSCDGSVKVTFKCETEYAFNLDSRYTNNPLEKTVVRALH
GPWNINLPEKMEETKLLLHMWVALFHRNENKVIQSSRKVVEHSNPAKYVSLNSTLECFEL
SEI-EESSSVEKCS----VEPLLETNG

PF12509 // ENSGT00530000063735_1_Domain_4 (1288, 1581)

MPRGHADGVSFRGPDCLLPLLKLPSSREAELCV
QGEQKETFATECH-ADTSESHNFAY-SCNNE---VIGGKAKQESTDKLEASNLV-LSVTG
NTQTNEPSISDKDKTFQSLDSKRM-----------------VSRNNTGTQATF-----TR
TYDEPNSQSE--------------------------------------------------
--------------------------------------------------------MCGR
------SVHSPLE-----STVDTLHTAVQT------NTSALKDLIQHSNPMH-SEFQSSL
ERT-DDNMEYMMINLEPVTF----------------------TLEKNASTPVHT------
-EVRRAEKLTAFSSESIKQVSPAANVRHPISASEEAQTE-------GVRDIPSLAVSGQK
STKYLSAFSGKRETLD-EELCSLRKEMPL-RISSPSPDKALIMEALSLV-----KRSSYP
LPSAEMKHSQEVCLQTQNLFSISSEEIIEPSQVEV-VSPSACASLG--KRYSHDCIPSKS
NVSGDSLEPRKNDKSSLSCANVNLESFSSVFA-EQTNLPMNGQEVGLEL--QEENSDIDL
TLTISPPTSPSGKVPTNETEQLQEA-PGSNLELQDVAKEIV-EPE-------EMTLIEKR
DMNSASSMSAYSTVSKE-------------------------------------------
-PLEDKERKGDSLQPITLILSKHNCTFEIGEEINVTSDFPF-NSLIEEVSPASSPDPLVP
MEETWSS-----QAVSPSSLKLHGTQCEKS-KFSKVESEDLAVTE-------KQNSFIG-
PTPLVGQENLTQLQQIQLSANVPLML-T-NPGTKG--TLML---PGKTTEEIAPS-----
---------------------------------------EHGE-----GLSFSDKVQCC-
DP-ELN---------------------------NPAV-V---ANYGNNI---KPSLEK--
----LVKAGNPLHPVCIENKNLGLEHPVLE-SNKPPFSCRKTIENKSLADTLVPTTALSG
IGNIPLK-------------------EQGSPESTKENLCDGDLKT------DGGSNMQGK
LMNSASIAETDVT-QAYLRPEIPGFGSASDRA-TFTQCARPESEEPGFQTHEISVIRMAS
LLGSSRTEAELHENGTDRGAVSLQSNSTPSAKGEQEAVYTLPGTSVCEIKELL-------
--------NGEFLP----TDVC--SYKNTIHTSESIS-EEP-SAFVPESV-ETV----VY
GVSEEHIDRKTATRGHRDE--VDSAILGRNTGVSR----NSDMHYEPLSGDSDED-SLDN
CRN-PRLDMENS-SILSSSYTSKDEHAAEDGYDSLRSL----NNSDNEAYDYSN--DIQE
MEISIPPRNWA--PG----LEKAAKCVPHYVQIRDLHGIPRNYANFTVTREFKDTTRTL-
HRVTRHPSCTVNCGLLSSWTSTWQ-VTDDLTQNTLDLEYLRFTHKIKQVVK-GGCRQ---
-------PDPLLHISLRDFPLTEVSEPLVL-HPTCRSRSPILVTVLHSDASFARQQS-QH
RSGRSLSDVDS--SSSFWKERCSHS--RN-LTDAH-RNQAVSFHLNKLRYNS--TLKESR
NDISLILNEYAEFNKVVMNSSHDDFQ-DKRLNRA-SEEAV-APEMYPSLPRQSTSYEDVI
TDLCASLHTKLNSVLKEACKSPFFFYLVETE-DNPFFSRTKSILRKGGHTEIEPQHFCQG
FYRMID--TLVVIIRNEDISSHLHQIPSLLRLKHLPGVIFAGVDDPEDILNDTHQELFRT
GGFVVSDDRILETITLAQLKEIVKILEKLNG--NGRWKWLLHYRENKKLKKHIRMDSVAH
KKNLILRSYQSANIIELLPYHHCDSRLQTKAEILKCLINLQIQHVDARFAVFLTDKR-T-
-SSEVFGNNGILATDINHFIE---------NIQHIAAPFRSSYW----------------
-----------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------MSR-L-ISS--LFPGFFKGLICPWKGRLVVQ
GCLLSDITLWPTRGTVFPSQLPQELDFKYVMKVSSLKERLPEDAFRRRNYLEEKVYCQNL
CFDLY

PF12480 // ENSGT00530000063735_1_Domain_2 (426, 522)

EVELSNKQGENIDKLTEYIKNKQ--------------LAIIKCLEDRGFFILLTS
SALIAESDF--GA-EQMGLHGLHLFHSP------LS-TGVQ

ENSGT00530000063735_1_Linker_2_3 (522, 962)

DLKIE---DDISLKVIPIL
PAFNCALLEAKKSLSEERTPPNMLVKHNFQELYKMDKSLSLM-AAPWDAVKEIGLARK--
-WSTGSDLVP-PPEKCSLDSLIQLKAYLSDPDGYTLEVATVLDSLVEHPLSPC-ISDGVC
DAGFSLVMTPDPEFLDSEAEVETE-----KSAEDMLTEESAVVVVSP-ASALRAQP-KRK
ASP---------------------------PAGVNLCRPLPERAVPWTDNELHTSTTLKL
AKGQFSPKRKR-GAEVLTAQFVQKTKPVRKNPDPPYSNSKDVPVKTNTKRARKQEKA--Q
VIPKAKPPVKK---KRKGTVLRGHQKPRHRKQPQS---ETTLYLQSEISSDGPKDGINI-
CIAQSERIGVA-PKDLPENSIISFDSQALNMLADLALSSAAVC-TPSCEPKAL----PI-
C

PF12509 // ENSGT00530000063735_1_Domain_3 (962, 1130)

ELPQS-TVLPS-KENSLHSTSDHEYHRGVKSQKSIPQPKPPSD------RKSNSESDFA
VSQE-GKLLPGSQ---------PPAQAQLVLSEEAQEP---S--DTGQSS-VAVEHSYAL
LLAEQSKKHL--HQRRLPSPAFAKNGTKGPEAGTPVGKVMPFRHLQNTS

ENSGT00530000063735_1_Linker_3_4 (1130, 1289)

PLQKLPEDSLI
KRKSRCVSSNLKDFFC-SHTVLNSDGSLKVTFKCEAGYAFSLDSKYTSNPLEKTVVRALH
GPWNMNLPENMEEVKLLLHMWVALFYSKKNRVMGSPRKVVEHRNPAKYVCINRSLESIDL
SEI-EELSGVERCP----VDPLLETNTM

PF12509 // ENSGT00530000063735_1_Domain_4 (1289, 1573)

SNGRAAEVPFPGPDCMLPFIKPPTTRDLELCV
QNEQKELFAGHCH-LDASESQSFIY-SGDNE---VFGRKSKQDLSDKLEASNVV-PSGIA
STQTNGSCIPSEDKSFQSGDGTGM-----------------VSCDDTVTQTTF-----TT
AYDGTSSQSV--------------------------------------------------
--------------------------------------------------------MCPK
------SVFSTLE-----NKLDIFHPTMQT------KTGVVQDFVQHSSPMN-NGCLPSP
ERM-GDNSEYMVINLEPVTL----------------------AFGKNACS----------
-EVSIADRSTDFHTEVVKQVLPVVNVQHPVPTLEKVQTL-------DLTDSPFL-LSGQE
DAKYLPASSVNKDA-R-EDLYPVQRETPL-SVSSQPDESASVMDAVPLA-----KRPRYS
PASEEMKCPQDALLQTANLFSTPSEEGTEPSQGAV-----TSPTLG--KKCSLDCIAPRS
DTSDGFLELRNGDQSSPNHKR-ILQSFNLLLS-NQTNLSVNE-----EL--SREDSDTDL
RLTVLPPASPREAMPAGEMEQVQVA--ASSLGLIEGLEKVVELEE-------EATLIKKR
ELMPASYMSLWPLVSGE-------------------------------------------
-PLGNE--RKG-------------DTLKPVTEINMTSSFPF-DSLIE-VSPPSSPDPQ--
----AVS---------PCSLKHHGIYGEKSNKLSQIGSVELGMPE-------KENSYVS-
PAHPLEQAKFTPGQHSHLSAEVPLVL--T-----G--CPAA---PDPATEQVVPS-----
---------------------------------------EHGE-----GTFSSRKVQGD-
GA-ELN---------------------------KPTS-L---AKYRS-----D-PLEK--
----LVKPGNSLQLVSVEDSNLGLKHFVSE-SNVPPFSPRKIVENKPLADMLPPTSAVSG
VVNVSLK-------------------Q-KTSRENKRAVHNSHLKT------HVDSYTQAE
SVNSASIDGADVT-QVYMYPEIPELASPSDSA-TCTHGTRSVRREPEFQTREIPVVRMAS
LLTNNEAEAELCEDRTGLRAAGLHSHATS-IEGEQKLAHMLQGTTACERRELL-------
--------NDSGLP----TCV--VSYQHTANSGKSTS-KTPHASLIPESF-DTV----TC
GISKDDAPVESISEGHIAK--ANSEALSRDAEKNI----TADIYYEPLSGSSDQD-AV-D
CAN-PKVDMEKS-YSLSS-LASN-KDKIRDHYDLCMNL----KNSN-DGSAYSN--KLEE
LEIHTSPKNWT--IGPYS-VLKKDKYVPGYVQIPDPHGILRTYANFTITKEFKDTRRTL-
HGLKRRRSLPAKCSLLSSWTSTWQ-VADDATQNTLDLECLRFSHKLKRVLKK-GDSQQSA
PFT-ISPKELPTQVEVETCPAMG-------------------------------------
--------ILD--SPSSWKEKCTSS--RN-LKNSE----RNSFHLNKLKYNS--IAKESR
NDISLILSEYAEFNKVMMNNSQ-----ERELSTA-SREAA-SQGLSPSLPRQTPSYKDII
TDLCDTLHVKLKGVLREACKSPFWFYLVETE-DKPFLLRTKNILRKGGHTEIEPLHFCQA
HHREND--TLIVIIKNEDISSYLHQIPSLLKLKRLPSVVFAGVDGPEDILNDSYEELLHS
GGFVVSDDKLLETLTLVQLKEIVKTLEKLNE--NGRWKWLLHYRENKKLKEDVRVDSTAQ
KKHLILKSYQSADIIELLHYHHCDSLLPKKAGILKCLLKLQIQHTSTRFAVFLTDKPAV-
-STEVFESNGILVTDVNYFIE---------NMQKVASPFRRSYW----------------
-----------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------MAAPP-HTSILE--VSKNVLISPWKGKLTIQ
GCMLCDITLWPNYGAVIPAHLPHELDFKYVMQVSSLKERLPEAAFRKQIYLEQKVCYQDL
CFNLY

PF12480 // ENSGT00530000063735_1_Domain_2 (426, 522)

EVELSNKQRKEVDTLTEYIKNNQ--------------LAIIKCLEDRAFFILLSS
AALITEPDI--GD-EQMSLHVLHLFHSP------LA-TEVK

ENSGT00530000063735_1_Linker_2_3 (522, 949)

ALKIE---DDISWKVAPIL
STLNCALLEAKKLFPEEGTHPNILVKHNFQELNKVDKSLSLT-AAPQDVKKETTFFRK--
-LSGSFDLVP-PPEKCSTESLTQLKSYFSDPSGYTLEVSTALGLLAERPPSPY-ISDGIC
DAGFSLVMTPDPEFPDSEAEVRKETQTEKSSEEMFKAKKGAVVPLSA-ASNLRVQP-KRK
ASMLPIM---------------------P-SKRVNLCRPFAKRATAGTDSRSYSPPTLKL
VKGQLPQKRKR-GAEVLTAQFVQKTKSNRRNQEVP--ISKEVPVATNTKRARRQEKSTVK
TVTRVKPPVKKSPQKQRVNTVKGSQNPRIRKQPQPAKEETALQLQSEISSDGQKDGNSI-
NVDQPQSTTVA-QKDLPEDSIVNYDSQALNMLADLALSSAASS-TPLC

PF12509 // ENSGT00530000063735_1_Domain_3 (949, 1130)

EARNL----PCS
SELPQN-NILLS-KESSLCGTPDHDYHSGVKSQKGVLLSKSSCD------PKSNSGSGLI
VSQEEENLITCSQ---------MPADAQSALHEETSEP---L--GTGPNCPITVEHSYAL
LLGEHSKKYL--QQRGLSGPAFAKTGTKGPEAGTPVGKVTPFRHLQNTS

ENSGT00530000063735_1_Linker_3_4 (1130, 1287)

PLQKLSEGSLV
PRRGRFISSNLKSVFC-SHTIISCDGSYKVTFKCETEYAFNLDSKYTNNPLEKTIVRALH
GPWNTNLPDNMEEVKFLIHMWVALFYRKRNKDIQSSRKVVEHSNPAKYVSINSTLESFEL
SEI-EESSSVERCS----IEPLLETN

PF12509 // ENSGT00530000063735_1_Domain_4 (1287, 1572)

EMSRAHGDEESFHGPNCLLPLIKVPPSRGLGFCV
QNERKEIFATECH-PHNSENQNLIY-SYNNE---VIGGKAKQESADKLEAPNLA-LSLIG
NTQTNGPFISDEHKTFQSLDSKRM-----------------VSYNGAGTQATF-----TR
TCDEASSQSK--------------------------------------------------
--------------------------------------------------------MCEK
------SVYIPLE-----SRVDILHAAVPT------NPSALQDFIQCSSPMN-NECESSL
ERP-DADMEYVMINLEPVTF----------------------TLENNPCVPVHT------
-EVNRAEKPVAFSRELINQVSPAADVRHPVTALEEVQTQ-------AIRDVPSLAVSGQR
STQCLSASSGKRETLD-EELLFVQKEMPL-PVSSPLPDRALIMEALSLV-----KCSGYP
LPSKEMKHSQDICLQTQNLCRISSEEIIDSSQVEV-VSPSVSASLE--KRYSNDCVPPKS
NISDDSLELRKNDKSGLNCENTNLESFNSVFA-KQTNSPINGQEIGLEL--QEANSDIDL
TLTITPPTSPRGKVPANETEKLEEA-PGSNLELKDVAEEII-EPK-------EVTFIEKT
EANPPSSMSVYSAGSNE-------------------------------------------
-PLKN-ERKGDSLQPITLILSKENCTLEIGEEINVTSDFPF-DSLIEEVSPASSPDPPVP
TEETWPP-----QAVSPCSLKLHGTQCEKGNRFSQIESNDTAVTE-------KENSSID-
PSRLVRQENITQLQQIQLSAKMPLLL-TDHPGGKG--TLMF---PGKITEEIVPR-----
---------------------------------------EHGE-----GLSFSEKVQCY-
DA-ELN---------------------------KHGL-V---ANYGDNS---KLSLEK--
----LVKSGNPLQPISIENRNLDLKHLVLE-SNESSFSSRKSFENKSLADGLVSTTALSG
TVNIPLK-------------------EQGSPESIKENLCNGNLKT------DGGNHMQVK
SVNSAAIDGADVTVQAYLHPEIPEFDSASNSA-TLTQCTRPESIELGFQTQEKPVIRMAS
LLGNIGAEAELLEV-TGVGSNSLQSNSTVSTKSE-ETVCLFSDTSVCEMKELL-------
--------NADFLP----TYVC--SYQNNIDASE----EPP-AAFVPESV-ETL----VY
GVSKEHTDRKTASEGHGDE--VDSKILGRNIDVNM----NSDMQYEQLSGDTDQD-SFSN
CRN-PKLDMENS-GILS-SYTSKNEHVVKDSCDSFMCL----NNSNNEACDYSN--KVPE
VEMNIPPRNWA--TG----LKKANKHMPHYVQIQDRHGIPRTYANFTITREFKNTTRTL-
HRVRTPPSFTVNSDLLSSWTSTWQ-VADDLTQNTLDLEYLRFAHKIKQLVKKESSRQ---
-------SDSSLQISLRDFPFTEMSEPPVL-LPTPRSRSPILVTVMHSDAGW---QS-WH
RSCQTPSDLDS--SSSFWRERFSHS--RN-LTDSQ-RNETVSFHLNKLKYNS--TLKESQ
-NISLILNEYAEFNKVMMNSNHADFQ-DKELNIA-SEEAT-SQEIHPFFPRQSTSYEDVI
TDLCASLHTKLNSILKEACKSPFFFYLVETG-DKPFFLGTKSILKKGGHTEIEPQHFCHT
FHGEND--TLIVIIRNEDISSHLHRIPSLLKLKHLPGVIFAGVDNPEDVLNDTHQELFHT
GGFVVSDDKILETVTLAQLKEIVKILEKLSG--NGRWKWLLHYRENKKLKENVRMDSVAH
KKNLILRSYQNASIIELLPYHQCDCRSQTKAEILKCLINLQIQHVDARFAVFLTDKH-F-
-SSEIFGNNGILAIDVNDFIE---------NIQKIAAPFRSSY-----------------
-----------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------MAPPV-H----------KILMSPWKGQLIVQ
DRMLCDITLWSTYGAMIPTQLPQELDFKYVMKVSSLKKRLPEAAFRKQNYLERKVCFQDL
SFNLY

PF12480 // ENSGT00530000063735_1_Domain_2 (426, 522)

EVELSNRQGENIDKLTEYIKNKQ--------------LAIIKCLEDRGFFILLTS
SALLSEPDFKNGG-KQMGLHGLHLFHSP------LS-TGVK

ENSGT00530000063735_1_Linker_2_3 (522, 949)

DLKIE---DDISMKLIPIL
PALNCALLETKKSLPEERIHPNTLVK-HFQELYKTDRSPSLT-VAPQDRMKDPTFLGK--
-LPSGFDLIP-PAEKCPSKSLTQLNSYFSDPSAYILEVSTALDLLAEHPQSPC-VSDGIC
DAGFSLVMTPDPEFLGSEAEVRKETETKKDSEEMLKAKKRVVVPLSP-ASNLRVQP-KRK
ASMPHVV---------------------Q-SKKVNLCHPFPKRTAPRADNSSKSPTTLKL
VKGQFPQKRKR-GAEVLTAQFVQKTKLDRKNQDAP--ISKDVPVPTNAKRARKQEKSPVK
TVPRAKPPVKKSPQKQRVNIVKGNENPRIRKQLQPVKGETASKLQSEISRDGQEDGISI-
NSVQPENTTVA-HNDLPENSIVNYDSQALNMLADLALSSATSS-TPVS

PF12509 // ENSGT00530000063735_1_Domain_3 (949, 1125)

EPRNL----HCS
SELPQN-DVLLS-KENSLRGTSDHEYHRGVKSQKGELLPNPSSD------RKSNSESDLI
VSQDEESLVPCSQ---------APAKAQSALTEEMLES---S--AASQSSSVSVEHSYAL
LLREHSKKNL--QEREIPSPVFPKNGTKSPEAVTPVGKVMPFRH

ENSGT00530000063735_1_Linker_3_4 (1125, 1287)

QPGLLLQQKPPDEPVV
KPKDRPASSRVKKCSC-SRIVFSCDDSVKITFKCETEYAFSLDSKYTNNPLEKTVVRALH
GPWNTDLPDNVEEVKLLLHMWVALFYSNQNKVIRSSRKVVEHSNPAKYVSINSTLESCEL
SEI-EESLGLERCS----ADPLLETN

PF12509 // ENSGT00530000063735_1_Domain_4 (1287, 1583)

EISRAHAAEVSFRDANCLLPFIKTPLTQGLELCV
HNEQKKTFARKFH-PDTLENQDFNVCSYNDE---VIGEEAKQESLDKLETSNLV-LSGIG
STRTNGPSVPNEEEIVQPLDSTRV-----------------ASYSGTVTQTTF-----TR
TYDGTGSQPV--------------------------------------------------
--------------------------------------------------------ICQS
------SVCSTLE-----NKVDVPDAAMQT------KTGTLQDLIQHGSPIN-NECHPSL
ERK-DDNMECAVINPEPVTL----------------------IFEKNAHIPLQT------
EGVNTADEPTTFNKELIKQVSPAASFRHPVSTSEKAQTQ-------GLRDIPSLVVAGQK
GSKYLCASSLGRETLD-EEVCSLQKEMPL-PV-SLPSDKAMVMEALSLV-----KSSSYV
LPSEEVRCTQNFLSQTQSLLSLSSEGLVEPTQVEV-DSSSASTALG--KQCSLNCISSGC
HTSGDFLELRKNDKNGPNTENMNFEEFDSVFI-KQRRLSVSR-EVSLEL--SEEDSNIDL
ALTISPPTSPREEMPAGEIEQFEET-PFSNLELQDVAEEIG-EPE-------EVALTESR
EVNSADNLSVYPTVSEE-------------------------------------------
-PVENKERKGDNLQPVTVILSKENCTLEIAEEINVTSDFPF-DSVIEEVSPPSSPEPPVP
VKETRPY-----QAVTPCILNLHGTQCEKSNRISQRVSEDLGITE-------KEKCFVG-
PAHPVGQDNFTQVQQMQVSAEMPLIL-TDHPGRTG--RPTF---PGKVTEDMVSS-----
---------------------------------------EHDE-----GLSFSGKVQCY-
GRE-LN---------------------------QPAS-A---AEYTGDF---SPS-EK--
----LVKSGIPLQPIRVENRNLDLKHLVLE-SSEPPFSPRNVTENMSLSDTLVSTAAPSG
V----VK-------------------QQTSPKSSQNNLFTSDLKT------DEGIYLQVK
SLTTASVDGAYST-QGCLCSVVPTLCSSSDSA-TLTHYVRPINAEPAFQAQEIPAVRMAS
LLKKDETEAELHKEITGLGTAGPQSNTKSSLKGERKAIHTLQDVSTCETKELL-------
--------NVGVSS----LCAS--PYQNTADTRENLS-KEPLASFVSESF-DTS----VC
GISTEHIEIENSGEGLRAQ--AGSETLGRDAEVSG----NSDMHYELLSGDSDLD-LIGD
CRN-PKCDLEDS-CTLRGSYTRKKEDVLTDGCVSSLNF----HNHHQGDWGCSS--QVPG
METGLPPGHWT--TR----VKKEEKCVPPYVQIQDLHGILRTYANFSVTKELRDTMRTS-
HSLRRHPSFTANCDLPSSWTNTWQ-VADDLTQNTLDLEYLRFAHKLKQTIKN-WDSQHSA
SSANVFPKELPTQISIGAFPLTKISEAPIL-HPAPRSRSPLLVTVVESDPR---PQG-QP
RRGYTASNLDN---SSSWRERDSHN--RD-LTNSQ-RNQTVSFHLNKLKYNS--TLKESR
NDISLILSEYAEFNKVMKNSSQVVFQ-DKELNDA-SGEAT-AQVMYLPFPRRSISFEDII
IDLCTNLHIKLRSVVKEACKSTFLFYLVETE-DKSFFVRTKNLLRKGGHMEIEPQHFCQA
FHREDD--TLIIIIRNEDISSHLHQIPSLLKLKHFPSVIFAGVDSPGDVLDHTYQELFRA
GGFVITDDKILEAVTLVQLKEIIKILEKLNG--NGKWKWLLHYRENKKLKEDERVDSTAH
KKNMMLKSFQSANIIELLHYHQCDSRSSTKAEVLKCLLNLQIQHIEARFAVFLTDKPTI-
-PREVFENSGILVTDVNNFIE---------NIEKVAAPFRSSYW----------------
-----------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------MAAPA-HDHKSILELRENVLISPWKGKLIIQ
GCLLCDITLWSSYGTAVPKQLPHELDFKYVMKVSSLKERLPEAAFKKQNYMEHKVCCQDM
CF

PF12480 // ENSGT00530000063735_1_Domain_2 (423, 508)

NMYEVELSNKRGEKVDKLIESIKREQ--------------LAIIKCLEDREFFILLTS
SALMYETGF--RE-EQTGLHGLHLFHSP------PPAAGLTDLKVE---DNISLKVVPVL
PALNCALLEAKKSFSEKGISLNTLVKHNFQDLSKVNKSPPLT-AASQDGFKETGFSGQ--
-VSSGFDLTP-PAEKCPLQSLTQLKSYFSNASGYILGVSTVLGLLAERPQSPS-ISDGIC
DAGFSLVMTPDPEFHNSEAEGRKDTETGNNSEDVFQARQGALVPLSL-APNLRVQP-KRK
ASKLPMV---------------------Q-SKRVSLYRPFPKRTPARENKGPASSTTLKL
VKGQFPQRRKREGAEVLTTQFVQIPKLGRKAQEAP--SSKDVPVATNAKRARRRATSPDT
PVPTAKPPMKKPPQKQRVNIVKGNQNPRLRKQPQPAKGETALQLQSEISSG--QDVISI-
NTAQPEHVTVA-PKAPTETSVVGCDSQALNMLADLALSAATSS-TTSPEPRNL----SGS
LEPPQN-SVLLS-KEQPLRGTSDHEYHRGVKSQKGGPSPKPSSD-------QSRLSSDPT
VSPEEESVGPGSW---------APAEAQPALPKEIHES---S--DASQSSFVAAEHSYAL
LLVEHSK-------RGSPALAFAKTSTKGSDMGTPVGKVIPFLRTKMKSPLQKLSMALAF
RHRGRLLPTGTQDFRCSSHTVFCCDGSFKVTFTCEADYSFSLDSKYTNNPLEKTVVRALH
GPWNTDLPDNVEEVKLLLHMWVALFYSRQNKVVRSSRKVVEHSNPAKYVSINSTLESFEF
GEI-EEPSRVERFS----VDPLVEASEAPRGHAAEVSCPDADPLRPFTKPSPVRGLELWV
QNEQKEMFATVGH-QESPESQNFI-CSYNNE---IIRGKAEQESSGKLETSNLV-LPCIG
NTQANGPSIPGEDETFEPLDNTQV-----------------TSYNDTAPQTTF-----AK
TYDEINSPSM--------------------------------------------------
--------------------------------------------------------ICQK
------SVYSTLE-----SKVDIFHAQRET------EADALQGLTQCS

PF12480 // ENSGT00530000063735_1_Domain_5 (1609, 1717)

SPIN-KECQPLL
EGK-G-DMGYVMINLEPVTL----------------------TLEKSAYMPVQT------
EAVNRADKPTAFNVELTKQVSPAASLRHPVSTFEKSQMQ-------GLGENPSLAVSGPK
GTQYLHASSVRRETLA-EETCSLQKGQAV-AGSPSPSDNPMVMEALPLA-----KSPNYL
LPREEMKLSQEFLLPTQNLLSISSEEIIEPSQVEV-VPSSASAPLG--KKDSLNCITSLR
NTLCGSSEL-KKDKSGLNSENISIQSFNSTFT-KEAGLSVNGEEVSLKV--SEEDSNLDL
TLTLSPPTSPREEAPTGEVEQLREA-PLPCIDLQEMAEEIL-VPA-------EVPFIENR
DVNSAANTSV------K-------------------------------------------
-PAENKEGKGDHLQTVAFILSKETCTLEVAEEVHLASDFPF-GSLIEEVSPASSPDPQAP
VEEAPPA-----QATSPCGLKQCDALGEKSTSLFKVESGDLAITE-------KESSLVT-
ATHPVEQDNSAQVQQMQLSAETPLQL-QNRAGRKGR-FLIL---PGDVTQETGQS-----
---------------------------------------KCGE-----GFSLSGKGPDC-
DG-TVT---------------------------QPAC-T---ATYGG-------SLEN--
----LVSSGYPLQPMGVETCSPHPHHRVLE--TSEPFSPAEIPENK-SADMFVSTATPGA
VVT--------------------------STQSLPEDVLSSDVKT------HECCYILVK
SLRSDPVAGAEGV-QTHRQPEFPKPALPSGGA-TAAHSTGPSNTGTGFPTQEVPVVRMTH
LLDSEDSGAELQGRAVDPGGASPQVLTSS-PQGRQEPTCLLQEGSPCAVWDLL-------
--------RGGLLP----TYLQADAHPGTAAHGESAS-PEPNVSFAPRSG-APP----IG
GVSEEQLQRVSVGEA----------GTGGGMGVGV----LSDIYYEPLSGDSDQD-SVGE
YGH-PRYNTEES-RASQYGHTGKREGASKDSHDSFLSL----NTSDHHDWGYAS--QAPG
LETSIPPRSWL--GG----LKKEATCVPCYVQIRDVCGVPRSYANFTVTRELRDTPRTL-
HGLRRRPRGMAPCGLLSSWMDTWQ-RTDDLTQNTLDLEHLRFAHKLKQIVKM-GAAQHSA
LFPSAFPKEPPSQVTTGAFPGTPMPACLGL-PPASRSRSPLVVTVVHQMPN---------
-------HVDR---SSSWKKRCGHG--RNHLTNSD-QNQTASFHLHKLKYNS--TLKDSR
NDIAVILSEYAEFNKVMLSSRQV-VQ-DTEPPVA-LGAAM-PRELCVCGP-QPTSYEDLV
ADLCSSLRVKLERVVREACSSNFLFYLMETE-DKSFFVRTKNILRKGGHTEIEPQHFCQV
FQREKG--ALLVIIRNEDIASHLHQIPSLLKLKHFPRVVFAGVDSPEDILNNTYQELFRT
GGFVVSDDKLLETLTLVQLKEIVKILEKLNE--NGRWKWLLHYRENKKLKEDVRVDSIAH
KKNLILKSYQSANIIELLHYHQCDSRLSTKAEHLKCLVNLQVQHIHARFAVFLTEKPVV-
-SREVFENSGILVTDVNDFIE---------NIQKVAAPFRGSYW----------------
-----------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------MAAPA-RESILE--LSENVLRSPWKGRLTIQ
GCVLCDITLWPTYGTVLPTQLPQELDFKYAIKVSSLKKRLPEAAFRKQNYLEQKVCCQSL
CFNLY

PF12480 // ENSGT00530000063735_1_Domain_2 (426, 522)

EVELSNRQGEKIDKLTEYIKKNQ--------------LAVIKCLEDRGVFILLTS
SALISESDF--GA-EQMGLHGLHLFHSP------PS-AGVK

ENSGT00530000063735_1_Linker_2_3 (522, 949)

DLKVE---DDISIRVIPIL
PTLNCALQEAKKSFPEEATRPNTLVKHHFQELCKVDRSTSLT-TAPQGGVKETSFFGK--
-LSSGFDWVP-PAEKCPSESLTQLKSYFSDPSGYIFEVSTALDLLAEPPQSPC-VSDGIC
DAGFSLVMTPDPELLDSEAEVRKETETKKKSEEILKAKKGVVVPLSR-ASSLRVQP-KRK
ASTPPVV---------------------Q-SKKVNLCRPLPKRTAPRADSGLDSPTTLKL
VKGQFPQKRKR-GAEVLTAQFVQKTRLNRKNQEAP--IPKDVPVATNAKRARKQEKSPVK
TVSRAKPPVKKSPQKQRVNVVRGNQNPRLRKQPKPVKRETASQLQSEISSSGQEDGIGI-
NTVQPENTTVA-HKDLTEHSIVNYDSQALNMLADLALSSATSS-TPAS

PF12509 // ENSGT00530000063735_1_Domain_3 (949, 1130)

EPRDL----PCF
SELPEN-DVLLS-KENSLRGTSDHEYHRGVKSQKGGLLPKPSSD------KKTNSGADLT
VSQDEESLVPCSQ---------APAKAHSALSEEKPEP---S--DASQSTFVSVEHSYAL
LLAEHSKKHL--QQRGVPGPAFAKNGTKGPEAGTPVGKVMPFRHQQSIS

ENSGT00530000063735_1_Linker_3_4 (1130, 1288)

PLQKLPED-LM
KRKSRLMSSNLKDFHC-SHTVFSCDGSFKVTFKCETEYAFSLDSKYTNNPLEKTVVRALH
GPWNTSLPDNVEEVKLLLHTWVALFYSNENKIIRSSRKVVEHSNPAKYVSINSTFDSCEL
NEP-EDSPRVERCS----AAPLSETNE

PF12509 // ENSGT00530000063735_1_Domain_4 (1288, 1583)

ASRGPAAEVSFPDPRCLLPLIKPTPARGLALSI
QNEQEEIFARECH-PDTPESQNFLF-SYNNE---VIGEKAKEESSDKLETCNLV-LPRIG
STKANRPSLPGEDETLQLLDSTRV-----------------ASHNGTVTRATF-----TM
TYNGISSQPV--------------------------------------------------
--------------------------------------------------------MRQK
------SVYSTLE-----NKVDILHAKVQT------KSGAFEDLIQHGSPIS-SEGQPSF
EGK-DDNTEYVMINLEPVTF----------------------SFDKNAYVPVQT------
EVVNGADKPTTFNEELIKQVSPAASLRHPVSTVEMAPTQ-------GLRDIPSLAVSGQK
GTKYLCVSSVSRETLD-KETCSLQKEMPL-AG-SSPSDSAVVMEALSSV-----RGPGYP
LPREEMKHSQDFLLQTQSLCGISSEEPAEPTRAQV-DSSSASATLE--KKCSLNCTASRS
STSDGSFELSKNVRSDLNSENTNFESFNSVFI-KQTSLSVNREEVSLEL--SEEDSDIDL
TLTISPPTSPREEMPAGEIEQLQEA-PLSNLELQDTAEETV-EPE-------ELTLTENR
EVN-SGYVSVYPAVSEE-------------------------------------------
-PVENKRTKGDNLQPVTLILSKENCTLEIAEEINVTSDFPF-NSLIEEVSPASSPGTPVP
VEETRPF-----QAVSPCALRLHGTQYAKSNGFSHFESGDLGVTE-------KENSFVS-
PTPPVGQDNLTQVQQMQLSAEMSLIL-TNHPGRKG--RLTL---PGKVTKEVVPG-----
---------------------------------------QCDE-----SLPFSEEVQCC-
GTE-LN---------------------------QPAL-A---AEYRSDF---K-PLEK--
----PVKSGNPSQPISIENRNLDLKHLVLG-SSELPFNPKKVIENKSLG-----------
---------------------------------IKKNLFNRDVKT------HEGSYMQVK
SLNSASVDGGFAT-QAHRHSEIPALGSSSDRA-TLTHYIRPMNAEPGFQTQEISVVKMAS
LLKNSETEAKLYEEAIDLGTIDPQSNTTS-SESEQKAIHKLQDVSQRVTKELL-------
--------NGGVFP----MCAS--SCQNTADFSENIS-KEPSASFVPEPF-EPP----AC
GVSKEHVDPEQSGEGFGAE--AGSETLGRDAEVSV----DSDMHYEPLSADSDLD-PLGD
CRN-PKLDMEDS-CTLRGGHTRRK-DAAKDGYDSLMNS----HSSDHKDWSCSN--SVPG
EDRNLPARHWA--SG----LKKENKCVPYYIQIPDLQGIPRTYTNFTITKEFKDTTRTL-
HHLKRHPNFTPNCSLLSSWTSTWQ-VTDNLTQNTLDLEYLRFACKVKETVKD-GDAQHPA
SSASVFARESPLQITLRALPLTKTSEAPVL-QPACRSRSPLRVTVVHSDPR----QS-QP
RRDPTPSNLDS---CS----SCGHS--RN-LTNSP-RNQIASFHLNKLKYNSN-TLKESR
NDISLILNEYAEFNKVMMNSNQVVFQ-DKELNVA-AGEAAVSQEMYLSCPRQPASYEDMI
TDLCTNLHVKLKSVMKEACKSTFLFYLVETE-DKPFFVRTKNMLRKEGHTDIEPEHFCQA
FHREDD--TLIVIIRNEDIASHLHQIPSLLKLKHFPSVIFAGVDSPGDVLDHTHQELFRA
GGFVISDDKILEALTLVQLKEILKILDKLNG--NGRWKWLLHYRENKKLKEDV-------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------MATPT-YKSILEL--NKNALISPWKGQLIVQ
GCLQCDITLWSTYGTVIPVQLPQELDFKYVMKVSSLKESLPEAAFRRQNYLEQKVCCQDL
CFDLY

PF12480 // ENSGT00530000063735_1_Domain_2 (426, 522)

EVELSNKQGENIDKLIEYIKNKQ--------------LAIIKCLEDRGFFILLTS
SALTPEPDF--GN-EQMSLHGLHLFHSP------QS-TGAK

ENSGT00530000063735_1_Linker_2_3 (522, 951)

DLKVE---DDISLKVIPIL
PALGCALLEAKKSLPEKGIPPNILVKHSFQDLYKVDKSLSLM-AP-QDTMKDTAFTGK--
-LSHAFDLAP-SLEKCPLECLTQLTSYFSDPSGYTLDLSTALDLLAEPPPFPC-ISDGIC
DAGFSLVMTPDPEFLDSEMEIRKETETTKKCGKTLRVKKRAVTPLTP-ASNLRVQP-KRK
ASTSAVT---------------------LPSKRVSLGRPLSKRATARADSGP-CNPTLKL
VKGQFPQKRKR-GAEVLTAQFVQKTRLDRKKRET--SV-QDAPVATNAKRAKKQEKSPSR
VVSRPKPPVKKSPQKRKVNVTRGRRNPRTKKQPQPAEEDIALHLQSELSSNGQKDGINL-
STAQQESIAVI-PKGFPENSIINCDSQALNMLADLALSSAASS-VPSCEV

PF12509 // ENSGT00530000063735_1_Domain_3 (951, 1130)

RNL----SCF
SELPQN-NVLFS-KENSLHGTSDHEYHRGVKSQKGVLLPKPSSD------EKINSESDLT
VSQE-ENLVLCDQ---------PLAIAQPAPPEEARES---S--DASQNS-VAVEHSYAL
LLAEQSKKHL--YQRKLPSPAFAKNGAKGPEAGTPIGKVMPFRHLQNTS

ENSGT00530000063735_1_Linker_3_4 (1130, 1288)

PLQKLSEDSLT
KRKSLFVSSILKDFFC-SHTVLSCDGSLKITFKCEGEYAFSLDSRYTSNPLEKTIVRALH
GPWNTDLPENMEDVKLLLHMWVALFYSKQNKVMGSPRKVVEHRNPAKYVCINRSVESFDQ
SDI-EEFSSVERYT----VDPLLETKE

PF12509 // ENSGT00530000063735_1_Domain_4 (1288, 1581)

AHEGHATNTTFPGPNCVLPFINPPTTRDLELCV
QNEQKEMFTGECH-LDTSGSQSCIY-SCNNE---VTGNKAKQELRDIPETSNVV-LSGVA
SAQSNGSCIPSEDKTFQS---TKM-----------------VSCNDSVTQATL-----TT
AYDGASSESI--------------------------------------------------
--------------------------------------------------------MCQK
------SGFSTLE-----NKVDIFHPSLLI------KTGAVQDVTQHSSVIN-NKCLPSV
ERM-DDNVEYMMINLEPVTL----------------------AFEKTAYVPIHK------
-EVNTADKPTGFNNELVKQVSPALNIQYPVSALEKAQTQ-------CPRDIPSLAISEYK
ENKCLSASSLKKET-P-ESQCPLQKEIP--PT-SA--DEGLITEALPLV-----KSSSYS
LASDKTKCPQDAFLQTQNDFSVSLDEVLEPSQVKV-VSLSTSATLE--NKQSLYCIPAIS
NISDGSTEVRNNDKSNLNQEM-TLQTLNSVFP-QQTDLSVNKEEVSMEL--SGEGSDTDL
TLTVSLPTSPREEMATCEIEQLQRA-PVLNLGLQNRNEEMVDSEA-------QVSLIKNK
EINLASCMSVYPVEPKE-------------------------------------------
-PLKN-------------------HAPKVAEEIKVSSDFPF-GGRIEEVSPASSPDPIVH
TEETQPS---------SC-LKLNDTQSEKSNKFYQIKSGDLTIPE-------KENPFVD-
PKTSISQ-----GQ-VQFSDEIPQVL--TNAGIEG--RVTV---PGEITEFIVPS-----
---------------------------------------EHKE-----SLSFSEKVQCN-
DK-ELS---------------------------EPTS-S---PKCEGNF---K-PLEK--
----LVISGNPLQAICMENRNLDTKPLALE-SSVPLCGPRKV-ENKSLADTLVSITTGSG
IVNVSLK-------------------Q-TSSKDNKKNVFDSDLKT------EADNTMQPM
SVNSASVDKNDVQ--TYIYPEISKFVSSSDSA-QCTYYTKPVSVEPLFQTQEIPVVEVAG
LLQNTG--TELHEERTDLSAIDLHPNSTS-TKDEQKTIHVLQDTSKCEEKMPL-------
--------NDGVFS----KIA--HSYQNTTDISKSVN-EGPFASFVLESI-DS-----VR
GIYREHIVSENSNVGHKTK--ADSETLNRNTEING----NASMCYGALSGATDQE-SL-D
CRN-CKLDLENL-CTLRGGHASQ-KDAVKDNNDSFTGL----NNSDNDTWVYSS--KISE
LETQIPPRSWE--MEPCP-ISTN-KCMPHYVQIPDSHGIPRTYANFTITKESKDTTRTL-
HSLKRHRNFTANCGLLSSWISTWH-VADDLTQNTLDMEYLRFDHKLKQVRKK-GDSQQSS
PSTNIFPKESLIRISVGTCPSSQTSDASLL-HLPPKSRSPILVTVVHSDTR---QQS-HC
QRGHSPSNLDS--S-PLWKEKRSQS--RN-LRNSE-RNQTVPIHLNKLKYNS--TLKEAR
NDISLILNEYAEFNKVMMNSNQIVSQ-DKRLSVA-SAEAV-SQE--TCQSRQSVSYKDVI
TDLCATLHLKLKGVMREACKSPFWFYLVETE-DKSFFLRTKSILKKGGHTEIELLDFCQA
FHRESE--TLLVITKNEDIISRLHQIPSLLKLKHFPSVIFAGVDSPEDILNDTYQELFRS
GGFVVSDDDILENLTLVQLKEIVKILENLNE--NGKWKWLLHYRENKKLKEDVRVDSIAH
KKNLILKSYQSVNIIELLHYHNCDSPSPTKAEILKCLLNLQIQHINARFAVFLTDKPKV-
-STEVFENSGILVADVNYFTE---------NIQKIAAPFKSSYW----------------
-----------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------LMSPWKGKLIVQ
DRMLCDIALRSTYGTAIPTQLPQELDFKYVMKVSSLKKRLPEAAFRKQNYLEQKVCFQDL
CFNLY

PF12480 // ENSGT00530000063735_1_Domain_2 (426, 522)

EVELSNRQGENIDKLTECIKNKQ--------------LAIIKCLEDRGFFILLTS
SALLSEPDF--GG-KQMGLHGLHLFHSP------RS-AGVK

ENSGT00530000063735_1_Linker_2_3 (522, 949)

DLKVE---DDVSVKVIPIL
PALNCALLETKKSLPEERIHPNTLVKHHFQELYKADRSPSLA-VAPHERMKDPIFLGK--
-LPSGFDLIP-PAEKCPLESLTELHSYFADPSAYILEVSTALDLLAEHPQSPS-VSDGIC
DAGFSLVMTPDPEFLDSEAEVRKETETRKNSEEVLKAKKRVVVPLSP-SSNLRVQP-KRK
ASMPHVV---------------------Q-SKKMNLCRPFPKRTAPRADNSSDSPTTLKL
VKGQFPQKRKR-GAEVLTAQFVQKAKLDRKNQEAH--ISKDVPVPTKAKRARKQEKSPVK
TVRRAKPPVKKSPQKQRVNIVKSNQNPRIRKQPQPVKGETVSKLQSEISRDGQEDGISI-
NNVQPENTTVA-HNDLAENSIVNYDSQALNMLADLALSSATSS-TQVS

PF12509 // ENSGT00530000063735_1_Domain_3 (949, 1125)

EPRNL----HCS
SELPQN-DILLS-KENSLRGTSDHEYHRGVKSQKGGLLPNPSSD------RKSNSGSDLT
VNQNEESLVACSQ---------TPAKAQSALTEETLES---S--DASQSSSVSVEHSYAL
LLTEELKKHL--QEKETPSPPFPKNGTKSPEAVTPVGKVMPFRH

ENSGT00530000063735_1_Linker_3_4 (1125, 1294)

QPGLLLQPKPSDEPVV
KHKDRPKSSSAKESSC-SHIVFNCDDSVKITFKCETEYAFSLDSKYTNHPLEKTVVRALH
GPWNTDLPDNVEEVKLLLHMWVALFYSNQNKVIRSSRKVVEHSNPAKFVSINSTLESCEL
SEI-EESLGLERCS----ADPLLETNEISRCHA

PF12509 // ENSGT00530000063735_1_Domain_4 (1294, 1584)

-EVSFRDPNCLLPFIKTPPTRGLELCV
QNKQKKTFAREYH-PIIQENQNF-VCSYNNE---VIGEDAKQESSDKLETSNLV-LSAIG
TTQTNGPSVSSEEEIFQPLDSTRV-----------------PSYSGTVTQATF-----TR
TYDGTGSQPV--------------------------------------------------
--------------------------------------------------------MCQS
------SVYSTLE-----NKVDVLDAPIQT------KTDALQDCIQHSSPIN-SECQPSL
ERK-DDNMEYVMINLEPVTL----------------------PFEKKAYVPIQT------
EVVNTADEPTTFNNELIKQVSPAASLRHPVSTLDKTQTQ-------GLRDIPSLVVAGQK
G---LCTSSVGRETLD-KEMCSLQKEMPL-PV-SLSSDKGMVMEALSLV-----KSSSYP
LPSEEVRCTQDFLSQTRSLLGLSSEGLLELTQVEV-DSSSPFTSLG--KQCSLNRISSGC
YTSGDSLELRKNDKNGPNIEKMNFKAFDSVFI-KQTSLSVNR-GVSLEL--PEEDSDIDL
ALTISPPTSPREEMLAGEIEQLQEP-PFSNLEHQDVAKEIG-KPE-------EVALTESR
EVNSADYELVYPAVSEE-------------------------------------------
-PVENKDRKGDNLQPVTLILSKENCTLEIAEEINVTSDFPF-DPLIEEVSPASSPDPPLP
VKETRPY-----QAVTPCILKLHGTQCEKSNRVSQRKSEDLGITE-------KENFFVG-
PTHPVGQDNFTQVQQMQVSAEIPLII-TDHPGRKG--RPTL---PGKVTEEIVSS-----
---------------------------------------EHDK-----DLSVSGKVQCC-
GRE-LN---------------------------QPAS-A---AEYRGDF---SPTPEK--
----LVKSGNLLQPISVENRNLDLKHLVLE-SSEPPLGPRNVTENKSLSGTLVSTAAPSV
TVNVSVK-------------------QQTSPKSSQKNLFNSDLKA------DEGIYPQVK
SLKAASVDGAYST-QGCVCSVVPTLGSSSDSG-MLTHYVRPINAEPGFQAQEIPAVRMAS
LLKNGETEAELPKETTGLVTDGPQSNAT-SLKGECETMHTLPNVSTCETKELL-------
--------NVGVFS----LCTG--LYQNTADTRENLS-KEPSASFVSESF-DTS----VC
GVSTEHVEIENSEEGHKAE--AGSEILGRDAEVNV----NSDMHYELLSGDSDLD-PLGD
CRN-PKFNLEDS-YTLRGSYTGKKEDVATDGYESSSKI----HN-NQEDWGCSS--QVPG
METSLPPRHWT--TG----IKKEEKCVPHYVQIRDVHGILRTYANFSVTKELKDTTRTS-
RSLRRHPGFTASCGLLSSWTSTWQ-VADDLTQNTLDLEYLRFAHKLKQTIKN-GDSQHSA
SSTNVFPKELPTQSSIGAFPLTKIPEAPVL-HPAPRSRSPLLITVVESDPR---PQG-QP
RRGHTASNLDS---SSCWRERC-HN--RD-LTNSQ-RNQTVSFHLNKLKYNS--TLKESR
N-ISLILNEYAEFNKVMMNSNQAVFQ-DKELNDA-SGEAT-AQEMYLPFPGRSASYEDVI
TDLCTSLHVKLRSVMKEACKSTFLFYIVETE-DKSFFVRTKNLLRKGGHTEIEPQHFCQA
FHREND--TLIVIIRNEDISSHLHQIPSLLKLKHLPSVVFAGVDGPGDVLDHTYQELFRA
GGFLVSDDKILEALTLVQLKEIIKILEKLNG--SGRWKWLLHYRESKKLKEDERVDSTAH
KKNIILKSFQSANIIELLHYHHCDSRSSTKAEVLKCLLNLQIQHINARFAVFLTDKPTI-
-PREIFENSGILVTDVNNFIE---------NIQKVAAPFRSSYW----------------
-----------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------MEPKTMAPPA-HKSILE--CSENVLMSPWKGKLIIQ
DRMLCDIALWSTYGAVIPTQLPQELDFKYVMKVSSLKKRLPEAAFRKQNYLEQKVRFQDL
CFNLY

PF12480 // ENSGT00530000063735_1_Domain_2 (426, 522)

EVELSNRQGENIDKLTECIKNKQ--------------LAIIKCLEDRGFFILLTS
SALLSEPDF--GG-KQMGLHGLHLFHSP------QS-AGVK

ENSGT00530000063735_1_Linker_2_3 (522, 949)

DLKVE---EDISAKMISIL
PALNCALLETKKSLPEERIHPNTLVKHHFQELYKADRSPSLT-VAPQERMKDPSFLEK--
-LPSGFDLIP-PAEKCPLESLTELHSYFSDPSAYILEVSTALDLLAEHPQSPS-VSDGIC
DAGFSLVMTPDPEFLDSEAEVRKETETRKNSEEVLKTKKRVVVPLSP-SSNLRVQP-KRK
ASMPHVV---------------------Q-SKKMNLCRPFPKRTAPRADNSSNSPTTLKL
VKGQFPQKRKR-GAEVLTAQFVQKARLDRKNQEAP--ISKDAPVPTKAKRARKREKSPVK
TVPRATPPVKKSPQKQRVNTVKGNQNPRIRKQPQPVKGETVSKLQSEISRDGQEDGISI-
NNVQPENTTVA-HSDLAENSIVNYDSQALNMLADLALSSATSS-TPVS

PF12509 // ENSGT00530000063735_1_Domain_3 (949, 1125)

EPRDL----HCS
SELPQN-DISLS-KENSLRGTSDHEYHRGVKSQKGGLLPNPSSD------RKSNSGSDLT
VSQNEESLVACSQ---------TPAKAQSAITEETLES---S--DASQSSSVSVEHSYAL
LLTEELKKHL--QEKETPSPPFPKNGTKSPEAVTPVGKVMPFRH

ENSGT00530000063735_1_Linker_3_4 (1125, 1287)

QPGLLLQPKPSDEPVV
KHKDQPKSSSVKESSC-SHVVFSCDDSVKITFKCETEYAFSLDSKYTNHPLEKTVVRALH
GPWNTDLPDNVEEVKLLLHMWVALFYSNQNKVIRSSRKVVEYSNPAKFVSINSTLESCEL
SEI-EESLGLERCS----ADPLLETN

PF12509 // ENSGT00530000063735_1_Domain_4 (1287, 1583)

EISRCHAAEVSFPDPNCLLPFIKTPPTRGLELCV
QNKQKKTFARECH-PVIQENQNF-ICFYNNE---VMGEEAKQE-SDKLETSNLV-LSGIG
TTQTNGPSVPSEEEIFQPLDSTRA-----------------PSYSGTVTQAAF-----TR
TYDGTGSQPV--------------------------------------------------
--------------------------------------------------------MCHS
------SAYSTLE-----DKVDVLDAPTQT------KTGALQDCIQHSSPVN-NECQPSL
ERK-DDNMEYVMINLEPVTL----------------------PFEKTAHVPIQT------
EVVNTADEPTNFNNELIKQVSPAASLTQPVSTLDKTQTQ-------GLRDVPSLAVAGQK
GTDYLCASSVGGETLD-KEMCSLQKEMPL-PV-SLSSDKAMVMEALSLV-----KSSSYP
LPSEEVRCTQDFLSRTRSLLGLSSEGLLELTQVEV-DSSSPFPSLG--KQCSLNRISSGC
YTSADSLELRKNDKNGPNIEKMNFKAFDSVFI-KQTNLSVNR-EVSLEL--PEEDSDIDL
ALTVSPPTSPREELPAGEIEQLQEP-PFSNLEHQDVAEEIG-NPE-------EVALTENR
EVNSADYESIYPTVAEE-------------------------------------------
-PVENKDKKGDNLQPVTLILSKENCTLEIAEEINVTSDFPF-DPLIEEVSPASSPDPPVP
VKETRPY-----QAVTPCILKLHGTQCEKSNRVSQRKSEDTGIT---------ENFFVG-
PTHPVGQGNFTQVQQMQVSAEMPLII-TDQPGGKR--RPTL---PGKVTEEIVSS-----
---------------------------------------EHDK-----ELSFSGKVQCC-
GRE-LN---------------------------QPAS-A---AEYRGDF---SPSPEK--
----LVKSGNLLQPISVENRNLDLKHFVLE-SSEPPFGPRHVTENKSLSGTLVSTAAPSV
TVNVSVK-------------------QQTSPKS-QKNLFNSDLKA------DEGIYPQVK
SSKAASVDGAYSM-QGCVCSVVPALGSSSDSG-TLTHYVRPISVEPGFQAKEIPAVRMAS
LLKNGETEAELPKETTGLGTDGPQSNTT-SLKGEGEAMHTLPNVSTCETKELL-------
--------NVGVFS----LCAG--LYQNTADTRENLS-KEPLASFVSESF-DTS----VC
RVSTEHIEIESSEEGLKAE--AGSETLGRDAEVSI----NSNMHCELLSGDSDLD-PLGD
YKN-PKFNLEDS-YALRGSYTRKKEDVATDGYESSLKI----HNQHQEDWGCSS--RAPG
METSLPPRHWT--TG----IKREEKCVPHYVQIRDVRGVLRTYANFSVTKELKDTTRTS-
HSLRRHPSLSASCGLLSSWTSTWQ-VADDLTQNTLDLEYLRFAHKLKQTIKN-GDSQHSA
SSTSVFPKELPTQSSIGAFPLTKISEAPIL-HPAPRSRSPLLITVVESENR---PQG-QP
RRGHTASNLDS---SSSWRERCSHN--RD-LTNSQ-RTQTVSFHLNKLKYNS--TLKESR
N-ISLILDEYAEFNKVMMNSSQAVFQ-DKELNDT-SGEAT-AHEMYPPFPGRAASYEDII
TDLCTSLHVRLRSVVKEACKSTFLFYVVETE-DKSFFVRTKNLLRKGGHTEIEPQHFCQA
FHKEND--TLIVIIRNEDISSHLHQIPSLLKLKHLPSVVFVGVDGPGDVLDHTYQELFHA
GGFVISDDKILEALTLVQLKEIIKILEKLNGNGNGRWKWLLHYRESKKLKEDERVDSTAH
KKNIILKSFQSANIIELLHYHHCDSRSSTKAEVLKCLLNLQIQHINARFAVFLTDKPTI-
-PREIFENSGILVTDVNNFIE---------NIQKVAAPFRSSYW----------------
-----------------------------------------

--------------------------------------------MAKIIKVEMKYFCIYD
INREQDCVKNSEGILGENELRPPSQLHSLSEKIETGSLS-------EKIFETVSLSSDSL
FQRAVSLLHTSYLDSSSEHGFQYSQVTLVKNDIFLNEYKTFYRQ

PF12509 // ENSGT00530000063735_1_Domain_0 (165, 316)

KKASNYTQEELQDTYG
FLLFDTEKEAKLVCQRGLRVGSSAVTTLGDPAKGVYISKYSDYLHPRPWYHGKSGYV---
---VIFNIIKGKVKSVSENYTTNYTKPSSGYDCHVSENTNKVSNKTSHFRAFELSQYYFY
ELSGNTVIERPRQIC

ENSGT00530000063735_1_Linker_0_2 (316, 426)

PYVIVAFRYREPKTMAPPA-HKSILE--CSENVLMSPWKGKLIVQ
DRMLCDIALWSTYGAMIPTQLPQELDFKYVMKVSSLKKRLPEAAFRKQNYLERKVCFQDL
CFNLY

PF12480 // ENSGT00530000063735_1_Domain_2 (426, 522)

EVELSNRQGENIDKLTECIKNKQ--------------LAIIKCLEDRGFFILLTS
SALLSEPDF--GG-KQMGLHGLHLFHSP------LS-TGVK

ENSGT00530000063735_1_Linker_2_3 (522, 949)

DLKVE---DDISMKLIPIL
PALNCALLETKKSLPEERIHPNTLVK-HFQELYKADRSPSLT-VAPQDRMKDPTFLGK--
-LPSGFDLIP-PAEKCPSESLTQLNSYFSDPSAYILEVSTALDLLAEHPQSPC-VSDGIC
DAGFSLVMTPDPDFPGSEAEVRKETETKKDSEEMLKAKKRVVVPLSP-ASNLRVQP-KRK
ASMPHVV---------------------Q-SKKMNLCHPFPKRTAPRADNSSDSPTTLKL
VKGQFPQKRKR-------------------------------------------------
-----------------------------------VKGETASKLQSEISRDGQEDGISI-
NSVQPENTTVA-HNDLPENSIVNYDSQALNMLADLALSSATSS-TPVS

PF12509 // ENSGT00530000063735_1_Domain_3 (949, 1125)

EPRNL----HCS
SELPQN-DVLLS-KENSLRSTSDHEYHRGVKSQKGELLPNPSSD------RKSNSESDLI
VSQDEESLVPCSQ---------APAKAQSALTEEMLES---S--DASQSSSVSVEHSYAL
LLREHSQKNL--QEREIPSPVFPKNGTKSPEAVTPVGKVMPFRH

ENSGT00530000063735_1_Linker_3_4 (1125, 1287)

QPGLLLPPKPPDEPMV
KPKDRQASSRVKK-SC-SRIVFSCDDSVRITFKCETEYAFSLDSKYTNNPLEKTVVRALH
GPWNTDLPDNVEEVKLLLHMWVALFYSNQNKVIRSSRKVVEHSNPAKYVSINSTLESCEL
SEI-EECLGLERCS----ADPLLETN

PF12509 // ENSGT00530000063735_1_Domain_4 (1287, 1583)

EISRAHAAEVSFRDPNCLLPFIKTPLTQGLELCV
QNEQKKTFARKRH-RDTLENQDFV-CSYNNE---VIGEEAKQESLDKLETSNLA-LSGIG
STRTNGPSVPNEEEIVQPLDSTRV-----------------ASYSGTVTQTTF-----TR
TCDGTGSQPV--------------------------------------------------
--------------------------------------------------------ICQS
------SVCSTLE-----NKVNVPDAAMQT------KTGTLQDLIHHGSPLN-NECHPSL
ERK-DDNMECAMINPEPVTL----------------------IFEKNAHVPLET------
EAVNTADEPTTFNKELIKQVSPAASLRHPVSTSEKAQTQ-------GLRDISSLVAAGQK
GSKYLCASSVGRETLD-KEMCSLQKEMPL-PV-SLPSDKAMVMEALSLV-----KSSSYL
LPSEEVRCTQNFLSQTQSLLSLSSEGLVEPTQVEV-DSSSASAALG--KQCSLNCISSGC
HTSGDSLELRKNDKNGPNTENRNFEEFDSVFI-KQRRLSVSR-EVSLEL--SEEDSDIDL
ALTISPPTSPREEMPAGEIEQFEEA-PFSNLELQDVAEEIG-EPE-------EVAVTESR
EVNSADSVSVYPTVSEE-------------------------------------------
-PVENKERKGDNLQPVTVILSKENCTLEIAEEINVTSDFPF-DSVIEEVSPASSPEPPVP
VKETRPY-----QAVTPCILKLHGTQCEKSNRISQRVSEDLGITE-------KENFFVG-
PAHPVGQDNFTQVQQMQVSAEMPLIL-TDHPGRTG--RPTL---PGKVTEEIVSS-----
---------------------------------------EHDE-----GLSFSGKVQCY-
GRE-LN---------------------------QPAS-A---AEYTGDF---SPS-EK--
----LVKSGNPLQPIRVENRNLDLKHLVLE-SSEPPFSPRNVTENMSLSDTLVSTAVPSG
I----VK-------------------QQTSPKSSQNNLLTSDLKT------DEGVYLQVK
SLTTASVDGAYST-QGCMCSVVPTLCSSSDSA-TLTHYVRPINAEPAFQAQEIPAVRMAS
LLKNGETEAELHKEITGLGTAGPQSNTKSSLKGERKAIHTLQDVSTCETKELL-------
--------NVGVSS----LCAS--PYQNTADTRENLS-KEPLASFVSESF-DTS----VC
GISTEHIEIENGGEGLRAQ--AGSETLGGDAEVSG----NSEMHYELLSGDSDLD-LLGD
CRN-AKCDLEDS-CTLRGSYTRKKEDVPTDGCESSLNF----HN-NQGDWGCSS--QVPG
MEMSLPPGHWT--TR----VKKEEKCVPPYVQIRDLHGILRTYANFSVTKELKDTMRTS-
HSLRRHPSFTANCDLPSTWTSTWQ-VADDLTQNTLDLEYLRFAHKLKQTIKN-GDSQHSA
SSANVFPKELPTQISIGAFPLTKISEASIL-HPAPRSRSPLLVTVVESDPR---PQG-QP
RRGYTASNLDN---SSSWRERCSHN--RD-LTNSQ-RNQTVSFHLNKLKYNS--TLKESR
NDISLILNEYAEFNKVMKNSNQVVFQ-DKELNDA-SGEAT-AQVMYLPFPGRSISFEDII
IDLCSNLHIKLRRVVKEACKSTFLFYLVETE-DKSFFVRTKNLLRKGGHTEIEPQHFCQA
FHREDD--TLIIIIRNEDISSHLHQIPSLLKLKHFPSVIFAGVDSPGDVLDHNYQELFRA
GGFVITDDKILEAVTLVQLKEIIKILEKLNG--NGKWKWLLHYRENKKLKDDERVDSTAH
KKNIMLKSFQSANIIELLHYHQCDSRSSTKAEILKCLLNLQIQHIEARFAVFLTDKPTI-
-PREVFENSGILVTDVNNFIE---------NIEKVAAPFRTSYW----------------
-----------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------ME---------T--PAHKILMSPWKGKLTIK
NCVLCDITLWSTSGTVIPAQLPHILDFRYVIQVSSLKEKLPEAALRKQIYLEERVCSQDV
CFNFY

PF12480 // ENSGT00530000063735_1_Domain_2 (426, 522)

EVELSNKQRKEIDKLIEYVENKQ--------------LAIIKCLEDRGLFILLSS
SALRPEPGI--GD-EQMGLRALHLFRSP------LA-TEVK

ENSGT00530000063735_1_Linker_2_3 (522, 949)

VLKTE---DDISWKLAPIL
PGLNYALLEAKKFLPEERTHPNVLVKHNFQELLKVHKSLSLT-AGPQNGETETTFCEE--
-VSSRFDTVF-PTEKCSAESLTQLKSYFSDSSGYTLEVSTALNLLAEHPPSPY-ISDGIC
DAGFSLVMTPDPEFLDSEPEVRKTPRTEKNSEEMFKSKKAAVVPLSA-ASNLRIQP-KRK
ASMLPIL---------------------P-SKRANLCRPFAKRTTPGTDRRSYSPPTLKL
VKGQFPQKRKR-GAEVLTAQFVQKSKLNRKNQEVP--ISKDVPVATNAKRAKKQEKSPVK
TVRRAKPPMKKSPQKQRVNIVKGNENPRIKKQLQPAKEETALQLQSGISSDGQKDGINI-
NTAQPQSTTVT-QKDLPGNSIINYDSQALNMLADLALSSAASP-TPLH

PF12509 // ENSGT00530000063735_1_Domain_3 (949, 1130)

EARNL----PCS
SELPQN-DALLS-KDSSLSGTSDHEYHRGVKSQKGILLPKSSCD------QKNNSGSDST
VSQE-ENSVSCSQ---------IPANAHSALHKETLQPMLQF--GASQNTLIIVEHSYAL
LLGEHSKKHL--QQRGLPGPAFTKNGIKGPDTRTPVGKVMPFRHLQHTSPLQKLSEDSLV
KRRSRFVSSNLKNIFC-SHVVVSRDGSIKITFKCETEYAFNLDSRYTNNPLEKTVVRALH
GPWNINLPENVEETKLVLHMWVALLRRNRNEVIQSSRKVVEHSNPAKYVSLNSTLECFEL
TEI-EESSSVERCL----VDPLLETNEMSRGHGDEVSFRGPNSLLPLIKLPSSRALELCV
HNEQKETFATEYH-ADSSESQNFIC-SCNNE---IIGGKAKEESTDKLEASNL--LSVTG
NTQTNGPFISDEDKSFQSLDSKRM-----------------ISYN-TGTQPTF-----TK
TYSESSSQPE--------------------------------------------------
--------------------------------------------------------MCRK
------SVYSHLE-----SRVDNLRSAVQT------NTSALKDVIQHRSPVH-SECQSSL
EST-DDNMEYVVINLEPVTF----------------------TLENNACVPVHT------
-KVSRVENLTAFSSESVKKVSPATNNGHTLSSLEETQTE-------SVRDIPSLAVSGQK
STMYLSASSGKRETPD-EEQLSLQKEMPL-PISSPSYDKALIMEALSLV-----KHSSYP
SPSEEIKRSQDVCPQAQNLFSISSEEIIEPSQVEE-VLPSASASLG--KRYSHDPVSPKR
NVSDDSLELK-NNKSSLSCENMNLESFSSVFA-EQTNLSMNGQEVSLEL--QEENSDIDL
TLTISPPTSPRGKVPAKEAEQLQEA-PGSNVGLQDIV-EIT-EPE-------EMTLIEKR
EMNSASAISSYSTV----------------------------------------------
------------IQSITLILPKQNCTLEIGEKINTTSDFPF-NSLIEEVSPASSPDPLIP
TEET--------------CLKLHGTQCEKSNKFSQIESEDLAVTE-------KENSFVG-
PNPLVGGKNLTQLPKSQLSAQMPLIL-TNHPRTKD--RLIL---PDKTTEEIAPS-----
---------------------------------------EHSE-----GLSFSDKVQCH-
DP-ELN---------------------------DAAF-V---ASYGNNF---KPSLEK--
----QVKSGNPLQLINRESKNLSLKHLVSE-SNQPPFSSRKTIENKSLVDTLVSTTALSG
TVGLSLK-------------------EQGSPESIKRNLYDSDLKT------DGGSCIQVK
FMNAPSADEIGAK-QAHLHPEIPEFGSASDSG-AFTQCTRPESIGLGFQTQEISVIRMAS
LLGNSKTENELHQKDTDLGTISLQPNSTTFTESEQETVHTLSGTSVCEVKELS-------
--------KDEFLP----SDAC--SYKNTIHTSESIS-EEPFAACVPESV-EIL----TF
GVSKEHIDRKSASKRHKDD--MDSDAMGRNVDMSM----NPDIRCELLSGESDED-SLDD
CGN-PRLDMENS-GILR-SYTRKNEHATEDDYDSLSSL----NNSDNEARDYSN--EVQG
LEISSTPSSWV--TG----LEKADKCVPRYVQIRDFHGIPRNYDNFTVTREFKDMTRTL-
HRVKRCPSFTINWGLLSSWTSTWQ-VTDNPTQNTLDLEYLRFTHKMKQVVKKEGSRQ---
-------PDLPLQISLRDFPLTKMSEPLVL-HPTPRSRSPILVTVLHSDANFSQQQS-QY
KRSRIPSDVDS--TASFCKEGYSHS--RN-LTNSQ-RNQNVSFHLNKLKYNS--TSKESR
NDISLILNEYAEFNKVIMNSNHADLQ-NKELSRA-SEEAI-YQEMNPSFRRQSASYEDIV
TDLCASLHTKLNSVLKKACKSPFFFYLVETE-DKLFFSRTKSILRKGGHTETEPQHFCQA
FHRMLD--TLVVIIRNEDISSHLHEIPSLLMLKHLPGVIFAGVDDPEDVLNDTHQELFRT
GGFVVSDDRILETITLAQLKEIVKILEKLNG--HGRWKWLLHYRENKKLKEGLRMDSVAH
KKNLILRSYQSANIIELLPYHHCDSQSQTKADSLKCLINLQIQHVDARFAIFLTDKH-I-
-SSEVFGNNGILATDINHFIE---------NIQKVAAPFRSSYW----------------
-----------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------MAAPA-HNSIVE--LSKNVL-SPWKGRLIIQ
GCVLCDITLWSTYGTIIPTQLPQELDFKYVMKVSSLKKRLPEAAFKKQNYLEHKVSCQDL
CFDLY

PF12480 // ENSGT00530000063735_1_Domain_2 (426, 522)

EVELSNKQGERIDKLTEYIKNKQ--------------LAIIKCLEDRGFFILLTS
SALIPEPNL--GG-EQIGLHGLYLFHSH------LS-TGVK

ENSGT00530000063735_1_Linker_2_3 (522, 949)

DLKIE---DDISLKVIPVL
PALNYALLEAKKSLPEEGTCPSTLVKHNFQELYKTDKSPSLT-V-ARDGMKKTAFFGK--
-SSNGFDLVP-PPEKCPLQFLTQLKSYFSDPSGYTLEVSAALDLLAERPQSPC-ISDGIC
DAGFSLVMTPDSEFLDSEVEVRKETETEKNSEEISTAKKGVVVPLNP-ASNLRVQP-KRK
ASMPLLV---------------------Q-NKRVNLCRPLPKRTVPGTDSGSHSPTTLKL
VKGQFPQKRKR-GAEVLTAQFVQKTKLDRKNQEAS--ISKDVPVATNAKRARKQEKSPVK
TVPRAKPPMKKSLQKQRVNVVKGNQNPRIRKQPQPAKGETALQLQSKISSDGQKDGISI-
NTDQPESTTVA-HKDLPENSIMNYDSQALNMLADLALSSATSC-TPSC

PF12509 // ENSGT00530000063735_1_Domain_3 (949, 1130)

EPRIL----PCS
SELPQN-DVLLS-KENSLHGTSDHEYHRGIKSQKGVLLPKLSSD------RKSNSGLDLT
VSQEDECLVPC-Q---------APNEAQSASPEETVKS---S--DGSQNSLVAVEHSYAL
LLVEHSKKHL--QPRGLPGPAFAKNGTKGPDAGTPVGKVMPFRHLQNTS

ENSGT00530000063735_1_Linker_3_4 (1130, 1287)

PLQKVSEDSLI
KRKNRFVSSHLKDFYC-SHSVLSCDGSFKVTFKCETEYSFNLDSKYTNNPLEKTVIRALH
GPWNTNLPDNVEEVKLLLHMWVALFYSNQNKVIRSSRKVVEHSNPAKYVSINSTLESFEL
SEI-EESSSVERCS----VEPMLESN

PF12509 // ENSGT00530000063735_1_Domain_4 (1287, 1583)

ETSRGHATEMSFPGPNCLLPLIKPPPAKGLELSV
QNEQKETFARECH-ADTSESQNFIY-SCNNE---VIGEKAKQESSD-LETSNLM-LSGIE
SMQTNGPSISGEEKTFQLDDNIRV-----------------ASYNDTVTQATF-----TT
TYNGANSHSI--------------------------------------------------
--------------------------------------------------------VCQK
------SVYDTLE-----NKVDVGHASMQT------KTGTLQDLTQHSSPIN-SECQSSL
ERA-DDNMGYVMINLEPVTP----------------------TFEKNACVPMYS------
-EVNRPDKPTAFDTELMKQVSPPASPRHPISALEKVQTQ-------DLGDVPSLAVSGQK
ATNHLCASSVNRETLA-QELCSLQKEKPL-PVSSPPSNKTSIMEALALV-----KSSSYT
LPSEEMKGSQDCSLQTRGVFSISSEEIIEPSQVEV-VSSSASATLG--KGYSLNCIPPRI
SMSDGSLEIRKNDKSNLNHENTNVESFTSVFA-QQISPSMGREETRLEL--SEEDSDIDL
TLTISSPTSPKEEMVAGEIEQLQKA-PVSNLELQDTAEEIV-EPE-------EVTLVENR
GISSANYMSVCPVVPEE-------------------------------------------
-PLENKERKSNSLQPVTLILSKENCTLEIAEEINVTSDFPF-DSLIEEVSPPSSPDPPVP
TKETRPS-----QAVSPCSLEVHGIQCEKSNKLSQIGSGDLAVTE-------KENSFVS-
PNHPVGQSDLTQVQQTQLSAEMPLML-TNNPGRKG--RPIL---PGKVTEGTVPN-----
---------------------------------------EHNE-----GFSFSEKVQCC-
DA-ALA---------------------------KSAS-A---ARYRGNF---KPSVEK--
----LVKSGNPLQSVSIENRNLDLKHLVLE-SSEPPFSPKKIVENKSSADRLVSTTVVSG
IVNVSLK-------------------QKTNPKSITKNLFDSDLKT------DSGV----K
SMDSASIDRAGVI-QTYMPPESPKLGSSSDST-TFTHCTQSGNVEPGFQTQEISVVRMAS
LLKNSETKAESPEESIDLGTVSLQSNSTS-STKVEQKIHMSQDMATCERKDLL-------
--------NGGFFP----MYSGSNQ--NAADNSESIS-KET-----SASS-DSL----VC
GISKEHIDNKIPSEEYRAE--ADFETRGGETKMRV----NSDMHYEPLSGDSDRD-FLDD
CRN-PKLDMEDS-CTLRSSHTSKKEDVVKNSYESFMNS----NNSDNEAWGYN---RVPE
LETSIPSRNRS--IG----LKQEDKCVPCYVQIRDLHGIPRTYDNFTITKEFKDTSRTL-
HSLKRQPSFAANCSLLSSWTSTWQ-VADDLTQNTLDLEYLRFAHKIKQIVKKKEDSKKPA
SSPNIFPKESPTQIMVGTLPLTKISKAPVL-HPASKSRSPILVTIMHPDAR---QPS-QH
RRGHTPNHMDS--TYSFWKERCNHN--RN-LTNSQ-KNQSVSFHLNKLKYNS--TLKESR
NDISLILNEYAEFNKVMMNSNQVVLQ-DKELNVA-SGEAM-SQDMYPSLPRQSASYEDMI
TDLCASLHVKLKSVMKEACKSPFLFYLVETE-EKSFFLRTKNILRKGGHTEIEPQHFCQA
FHREND--KLIIIIRNEDLSSHLHQIPFLLKLKHFPSVIFAGIDSPEDVVNDTYQELFRT
GGFMISDDKILEHLTLVQLKDIVKILEKLNG--NGRWKWLLHYRENKKLKEDIRMDSIAH
KKNLILKSYQSANIIELLHYHHCDSRSPTKAEILKCLINLQIQHVEARFAVFLTDKPTV-
-SKEVFENSGILVTDVNNFIE---------NIQKVAAPFRSSYW----------------
-----------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------MAAPA-VKSILE--LSENVLTSPWKGKLIIQ
GCQLCDITLQSSYGSVVPIQLPHELDFKYVMKVSALKKKLPEAAFRKQNYLEQKVCCQDM
CF

PF12480 // ENSGT00530000063735_1_Domain_2 (423, 525)

DMYEVELSNKQGKKIDKLIEYIKNKQ--------------LAIIKRLEDREFFILLTS
STLLSETNF--GD-EQMGLHGLHLFHSS------PS-TGLKDLK

ENSGT00530000063735_1_Linker_2_3 (525, 933)

VE---DDISLKVIPIL
PALNCALLEAKKSFTEEGICPNTLVKHNFQELYKVDKSPSLT-ASSQDGIKETSFFGK--
-LSNGFDLVP-PAETCPLQSLTQLKSYFSDPSGYILEVSTALDLLAERPQSPY-VSDGIC
DAGFSLVMTPDPEFLDSEAEVRKETETEKNSEEMFKARQRAVVPLSP-ASNLRVRP-KRK
ASMPPMV---------------------Q-SKRVNLCRPFPKRTPAGVNKGSDSPATLKL
VKGQFPQKRKR-GAEVLTAQFVQTTKLDRKNQDAP--ISKDVPVATNAKRARRPEKSPVK
TVPRAKPPVKKSPQKQRVNIVKGNQNPRVRKQPQPAKGETASQLQSEVSSAGHEDVISI-
NAAQPENITVA-QKDLPDNPIVNCDSQALNML

PF12509 // ENSGT00530000063735_1_Domain_3 (933, 1126)

ADLALSAATSA-TPSSEPRTL----PCS
SEMPEN-NVLLS-KEHSLCSTSDHEYHRGVKSQKGGLLPKPSSD------KKSNSTSDST
VSQEEESVVPGSQ---------APVEAQLALPEETLET---S--DTSQSSFVAVEHSYAL
FLAEHSKKHL--QQRGVPGPAFAKSGTKGPEAGTPVGKVMPFRHQ

ENSGT00530000063735_1_Linker_3_4 (1126, 1251)

QNTSPLQKLSEDPLL
KRRSRLLSSSLKDFHC-SHTVFSCDGSFKVTFKCETEYVFSLDSKYTNNPLEKTVIRALH
GPWNTDLPDNVEEVKLLLHMWVALFYSNQNKVIRSSRKVVEHSNPAKYVS

PF12509 // ENSGT00530000063735_1_Domain_4 (1251, 1579)

INSTLESFEF
SEI-EESPNAESCS----VDPLLETKETPRDHPAEVSFPDTSSVLPFMKPPSARGLELWV
QNEQKEIFSREGG-PDTPESRNFIY-SSKKE---IIGGKAEQESSDKPETSNLV-LSGIG
STQTNGPSISGEEKTFEALDSPRV-----------------TSYNDTVTQTTF-----TK
TYDGISKQSL--------------------------------------------------
--------------------------------------------------------ICQK
------SLYSTLE-----

ENSGT00530000063735_1_Linker_4_5 (1579, 1609)

SKVDIFHATMQT------KPGTLQGLIQHG

PF12480 // ENSGT00530000063735_1_Domain_5 (1609, 1719)

SSIN-TECQPSL
ERK-A-DVGYVMINLEPVTL----------------------TFEKNAYVPIHP------
EVVNRADKPTAFNMESIKQISPPTSPRHPVSTFEKAQTQ-------GLRDIPSLAMSGQK
GTKYLCASSGNRETFA-KEMSSLQKEIPV-PGSSSPSDNSVVTEALSLV-----KSSNCS
LPKEEMKLSQEFCLQSQSLSSLSSEEIIEPSHVGEVASASASATLE--KNYSLNYIPSVG
SISDGSLEL-KNDKSGLNSENMNFESFNSTFT-KQTSLSLNREEVSLEL--SEEDSDIDL
TLTISPPTSPREEMPAGEIEHREGA-PLSKLDLQDTTEEII-EPE-------EATFVENR
EVNSTNYTSAYPTVSEK-------------------------------------------
-PLENKERKDDHLPTVTLILPKETCALEIAEEVNVSSDFPF-GSLIEEVSPASSPDPLVP
AEETQPS-----QALSLCSLKLHDTQCEKSDKFSQIESVDLAIAE-------KENSFVG-
PTNPVGQANLTQVQQMQLSAEIPLVLLNNHPGRRER-HFTL---PGKVTEEVVPS-----
---------------------------------------EHSE-----GFSFSEKVPHC-
DR-ELD---------------------------QPAS-A---ARYRDDF---KPSLEK--
----LVTSGNRVQPISVENRNSDLNHLVLE-TSEPPFSPGKIMENMHLADTFVSATAPSG
LVNVVLK-------------------QQTSPEGTKKSLFSSDLKT------GEGNYMQVK
SLSSDSVDGAGVT-QAHVYSESPELTCSSASA-ASTHRTGSLSAETGFQTQEISVVRMAS
LLKNSDTEAELHEKTIDLGGVGSQLNATS-PKDKQK-IHVLQDMSACETKDLL-------
--------NGGLFP----MYLHAESYQKIAVSSENAT-KEPSASFVPKSC-APL----VC
GVSKEHLENKRAGEGLRAT--EASETLGGDMEISVTPIMNSDIHYEPLSGDSDHD-SFGD
CRN-PKLDMEDS-RTLRCSHTKKREGASKDDYDSFLGL----NNSDNEDWGYSN--QVSG
LEASIPPRNWS--VG----LKKEDKCVPRYVQIRDLHGIPRTYANFTVTRELNETTGTS-
QSLRRQPGFAAQCDLLNSWANTCQ-AADDLTQKTLDLEYLRFAHKLKQIVKN-GDSQHSA
SSTNIFLKESPFQITAGAFPLTKLSESPVL-YPASRSRSPLVVTVMHSDTK---QQS-QY
TRGHTPSNLDT---SSFWKETCGHS--TNHLTNSE-RNQTVSFHLNKLKYNS--TLKESR
NDISLILNEYAEFNKVMMNSNQVVVQ-GKEPNVA-SGEAT-SQEMYSSFPRRSASYEDVI
TDLCTSLHMKLKSVVKEACKSTFLFYLIETE-DKSFFVRTKNILRKGGHTEIEPQHFCQA
FHREND--TLIVIIRNEDISSHVHQIPSLLKLKHFPSVIFAGVDSPEDVLDYTYQELFRT
GGFVVSDDKILETLTLVQLKEIVKILEKLNG--NGRWKWLLHYRENKKLKEDVRVDSVAH
KKNLILKSYQSVNIIELLHYHQCDSRSSTKAEHLKCLLNLQIQRIHARFAVFLTEKPTV-
-SREVFENSGILVTDVNNFIE---------NIQKVAAPFRSSYW----------------
-----------------------------------------

------------------------------------------------------------
----MKYLV----IFSMPVLTPS---FGYLKQLHYFCLC-------FTVFETVSLSSDSL
FQRAVSILHTSYLDSASEHGFQYSQVTLVKNDIFLN

PF12509 // ENSGT00530000063735_1_Domain_0 (157, 316)

EYKTFYQEKKASNYTQEELQETYG
FLLFETENQAKSVCQRGLCVGCSTVTTLGDPAKGVYISKYSDYLHARPWYHGKSGYV---
---VIFNLIKGRVKFVSENYTTNYTSPSSGYDCHVAANTNKVSHKTSHFRAFELSQYYLY
EVSGSSVIERPRQVC

ENSGT00530000063735_1_Linker_0_2 (316, 424)

PYIIVAFQYREPKRMAASA-HKSIFE--LSENALSSSWQGKLTVQ
GCLLCDVTLWSSDGTAIPTQLPHELDFKYVMKVSSLKKKLPEAAFRKQNYLEQKVCCRDL
CFR

PF12480 // ENSGT00530000063735_1_Domain_2 (424, 503)

TYEVELVNKRGGEVDKLTEHLTNKQ--------------LAIIKCLEDSGLFILFTS
SALIPETNF--RD-EQMRLRGL

ENSGT00530000063735_1_Linker_2_3 (503, 933)

HLSHSS------LP-AGLKELKGE---DDISSKVTPII
PALNCALLEAKKSFTEEGVCPNTLIKHSFQELCKADKGPALT-ATSQDGIQESTFFGQ--
-LSNGFDLAP-PAEKCPLQSLTQLKSYFSDPSGYVLEVSAALDFLAERPQSPC-ISDGVC
DAGFSLVMTPDPELLDSEVEVRKETETKKNPEEMSKARRGSLVPLSA-ASNLRVQP-KRK
ASTPPAV---------------------P-SKRVHLCRPFPKRNPAGASKGSSSATTLKL
VKGPLLPKRKR-GADVLAAHFVQTTQLDRKNQDAP--ISNDAPVATNAKRARKQEKSPVE
TVPRPKPPVKKSPQKQRVNLVKGNQNPRIRKQPQPAKGEAGSQLPSEISSVGREDVIST-
EAAPAEDSSVA-PRDLPENSMVTCDSQALNML

PF12509 // ENSGT00530000063735_1_Domain_3 (933, 1126)

ADLALSAATSA-TPPSEPRHL----PCA
SESPQN-DALLS-KEHSVRGTSDHEYHRGVKNQKGGLLPKPASQ------KKSSPASHCP
VSQEKESLAPASP---------APVAVPSALPEETMET---H--DASQSSFVAVEHSYAL
LLAEHSKRYL--QQRGIPSPAFAKNGPKGPEAGTPVGKVMPFRHQQSTSPLQKLCEDPAL
KLRGRLLSSSLRDSRC-SHTVFSCDGSYKVTFKCDTEYVFSLDSKYTNNPLEKTIIRALH
GPWNTDLPDNVEEVKLLLHMWVALFYSNQNKVLRSSRKVVEHSNPAKYVSINSTLESFEF
SEI-EESSSVERCS----VAPLLGTSKPPGGHAAAVSFPDTDSLAPSMKPPPAGGLEFWI
QNEQKDTFAREGH-PDLPGSQNFIY-SCHNE---IIGEAAERGPSDKLETSGLV-LATIG
STQANGPDIPGADKTFEPLDSTGA------------------TYNDTVAQTTF-----SR
TYDGLGDPLV--------------------------------------------------
--------------------------------------------------------ICQK
------SACGALD-----SAGDVFHAAAQT------EPSALQGLIRQSGPLS-GDCQPAL
ERK-G-DPEYVMINLEPVTF----------------------TFEKNTYVPVQTDVPVQT
DVVNTGREPTAFHPEWITPVSPTGSLRRPASAFEKAQTQ-------GLRDGPSPTVSKQK
GTKYLCASSLSEEVPA-EEMCSLRKGILV------PSGSLVVAEALSSF-----EGSNYP
APGEETKPSQELFLHTPSLLGISAEEVIEPSQVQDAVSLAASAALG--HGSARDRAPPAG
GATVGSSEP-VRDGHGLKSEQRNLESFPTACT-KQTGLSGSREEASLEF--SEEGSDLDL
TL-ISPPTSPREGAPAGAP---GEA-PGASLELQDATEEII-EPE-------EVTLLEDP
EVDSVNYTSMFPTMPEK-------------------------------------------
-SLESKERKGDSLQTVTLILSKETCALEIAEEVNVTSDFPF-ASLIEEVSPASSPDRQDP
VEAAHPP-----QALSLCGLQLASTLGEGNDRFSRMGSVNLALTE-------KEHSFVG-
PTYPVEQDNLGGVQQMQLCAEMPIVR-SKHPERRDG-CLTL---PGELTEEIGPG-----
---------------------------------------EHGE-----GFSVSEKLPF--
RAAELG---------------------------QPAV-A---ARYGEDV---KLSLEQ--
----LVPSGNPLQPVSIQNRN--FSSLVLE-TNEPPGSPTKMIENKSLADTFVSTTAPSG
TVNVALK-------------------EQTSPESIGNHLFSGGVKT------DEGLYLQAR
SLSSCSAGGAD-T-QTRGHSESPRLAFPSDGA-ALPRCPRPMDTETGVQTQEISVVKMAS
LLKNSDAEASFHEEATDLGGIDSQSSTTS-PEDKPDTVHVLQDRAVCETKDLL-------
--------DAGLFP----MCVPADSYHKTAITGENTS-REPCASVVPPTC-ASL----VC
GVSEEQTASQASGEGLRAE--EDSGTVGRDVHVSV----NSEIQYEPLSGESDQD-SCGG
RRN-PKSEVESS-CPLRCSQTKKEEDTSKDDYDSFPSL----NNSDNEEWGYSP--PAPG
LETGTAPRHWL--VG----FKKEDRYVPPYIQIRDLHGIPRTYANFTVTKELTDTTRTL-
HSLRRHPNFTAKCGLLSSWTNTWQ-VADDLTQNTLDLEYLRFAHKLKQTVKK-GDSQPSA
SSTSVFAKEAPLQTAAGAFPLTRVPESPAL-QLASRSRSPLVVTVVHSGAR---QPS-PR
GRGHAPGSWDA---SSLWRESGGPG--RNPRADSE-RNQAAAFHLNRLRYNT--SFRESR
NDISLLLREYAEFTKVVASSKPALRP-DRERGGA-PGEAA-PRQPRAAFPR-AASYEDLV
TDLCASLHVRLMSVVKEACRSPCLFYLAETE-DPSFSVRAKSVLRKGGHTEVEPQHFCQA
VHREND--TLLVIIRNEDVASRLHQIPFLLKLKHFPSVLFAGVDGPEDVLKHTYQELLQT
GGFVVSDDKILETMTLAQLKDVVRTLEKLNG--NGRWKWLLHHRENKKLREATRVDPVAR
RKNLILKSCQSASLIEPLPYHQCDSRAPTKAEHLKCLLNLQIQHVHTRFAVFLTEKPTV-
-SREVLENSGILVTDVKNFIE---------NVPKTAAPFKSSYWGGIAVSLA--------
-----------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------MAPPV-H----------KILMSPWKGQLIVQ
DRMLCDITLWSTYGAMIPTQLPQELDFKYVMKVSSLKKRLPEAAFRKQNYLERKVCFQDL
SFNLYEVELSNRQGENIDKLTEYIKTKRDCRIFLQLNFSFIFK

PF12480 // ENSGT00530000063735_1_Domain_2 (464, 522)

AIIKCLEDRGFFILLTS
SALLSEPDFKNGG-KQMGLHGLHLFHSP------LS-TGVK

ENSGT00530000063735_1_Linker_2_3 (522, 949)

DLKIE---DDISMKLIPIL
PALNCALLETKKSLPEERIHPNTLVK-HFQELYKTDRSPSLT-VAPQDRMKDPTFLGK--
-LPSGFDLIP-PAEKCPSKSLTQLNSYFSDPSAYILEVSTALDLLAEHPQSPC-VSDGIC
DAGFSLVMTPDPEFLGSEAEVRKETETKKDSEEMLKAKKRVVVPLSP-ASNLRVQP-KRK
ASMPHVV---------------------Q-SKKVNLCHPFPKRTAPRADNSSKSPTTLKL
VKGQFPQKRKR-GAEVLTAQFVQKTKLDRKNQDAP--ISKDVPVPTNAKRARKQEKSPVK
TVPRAKPPVKKSPQKQRVNIVKGNENPRIRKQLQPVKGETASKLQSEISRDGQEDGISI-
NSVQPENTTVA-HNDLPENSIVNYDSQALNMLADLALSSATSS-TPVS

PF12509 // ENSGT00530000063735_1_Domain_3 (949, 1125)

EPRNL----HCS
SELPQN-DVLLS-KENSLRGTSDHEYHRGVKSQKGELLPNPSSD------RKSNSESDLI
VSQDEESLVPCSQ---------APAKAQSPLTEEMLES---S--AASQSSSVSVEHSYAL
LLREHSKKNL--QEREIPSPVFPKNGTKSPEAVTPVGKVMPFRH

ENSGT00530000063735_1_Linker_3_4 (1125, 1287)

QPGLLLQQKPPDEPVV
KPKDRPASSRVKKCSC-SRIVFSCDDSVKITFKCETEYAFSLDSKYTNNPLEKTVVRALH
GPWNTDLPDNVEEVKLLLHMWVALFYSNQNKVIRSSRKVVEHSNPAKYVSINSTLESCEL
SEI-EESLGLERCS----ADPLLETN

PF12509 // ENSGT00530000063735_1_Domain_4 (1287, 1583)

EISRAHAAEVSFRDANCLLPFIKTPLTQGLELCV
HNEQKKTFARKFH-PDTLENQDF-VCSYNNE---VIGEEAKQESLDKLETSNLV-LSGIG
STRTNGPSVPNEEEIVQPLDSTRV-----------------ASYSGTVTQTTF-----TR
TYDGTGSQPV--------------------------------------------------
--------------------------------------------------------ICQS
------SVCSTLE-----NKVDVPDAAMQT------KTGTLQDLIQHGSPIN-NECHPSL
ERK-DDNMECAVINPEPVTL----------------------IFEKNAHIPLQT------
EGVNTADEPTTFNKELIKQVSPAASFRHPVSTSEKAQTQ-------GLRDIPSLVVAGQK
GSKYLCASSLGRETLD-EEVCSLQKEMPL-PV-SLPSDKAMVMEALSLV-----KSSSYV
LPSEEVRCTQNFLSQTQSLLSLSSEGLVEPTQVEV-DSSSASTALG--KQCSLNCISSGC
HTSGDSLELRKNDKNGPNTENMNFEEFDSVFI-KQRRLSVSR-EVSLEL--SEEDSNIDL
ALTISPPTSPREEMPAGEIEQFEET-PFSNLELQDVAEEIG-EPE-------EVALTESR
EVNSADNLSVYPTVSEE-------------------------------------------
-PVENKERKGDNLQPVTVILSKENCTLEIAEEINVTSDFPF-DSVIEEVSPPSSPEPPVP
VKETRPY-----QAVTPCILNLHGTQCEKSNRISQRVSEDLGITE-------KEKCFVG-
PAHPVGQDNFTQVQQMQVSAEMPLIL-TDHPGRTG--RPTF---PGKVTEEMVSS-----
---------------------------------------EHDE-----GLSFSGKVQCY-
GRE-LN---------------------------QPAS-A---AEYTGDF---SPS-EK--
----LVKSGNPLQPIRVENRNLDLKHLVLE-SSEPPFSPRNVTENMSLSDTLVSTAAPSG
V----VK-------------------QQTSPKSSQNNLFTSDLKT------DEGIYLQVK
SLTTASVDGAYST-QGCLCSVVPTLCSSSDSA-TLTHYVRPINAEPAFQAQEIPAVRMAS
LLKKDETEAELHKEITGLGTAGPQSNTKSSLKGERKAIHTLQDVSTCETKELL-------
--------NVGVSS----LCAS--PYQNTADTRENLS-KEPLASFVSESF-DTS----VC
GISTEHIEIENSGEGLRAQ--AGSETLGRDAEVSG----NSDMHYELLSGDSDLD-LIGD
CRN-PKCDLEDS-CTLRGSYARKKEDVLTDGCVSSLNF----HNHHQGDWGCSS--QVPG
METGLPPGHWT--TR----VKKEEKCVPPYVQIQDLHGILRTYANFSVTKELRDTMRTS-
HSLRRHPSFTANCDLPSSWTSTWQ-VADDLTQNTLDLEYLRFAHKLKQTIKN-WDSQHSA
SSANVFPKELPTQISIGAFPLTKISEAPIL-HPAPRSRSPLLVTVVESDPR---PQG-QP
RRGYTASNLDN---SSSWRERDSHN--RD-LTNSQ-RNQTVSFHLNKLKYNS--TLKESR
NDISLILSEYAEFNKVMKNSSQVVFQ-DKELNDA-SGEAT-AQVMYLPFPRRSISFEDII
IDLCTNLHIKLRSVVKEACKSTFLFYLVETE-DKSFFVRTKNLLRKGGHMEIEPQHFCQA
FHREDD--TLIIIIRNEDISSHLHQIPSLLKLKHFPSVIFAGVDSPGDVLDHTYQELFRA
GGFVITDDKILEAVTLVQLKEIIKILEKLNG--NGKWKWLLHYRENKKLKEDERVDSTAH
KKNMMLKSFQSANIIELLHYHQCDSRSSTKAEVLKCLLNLQIQHIEARFAVFLTDKPTI-
-PREVFENSGILVTDVNNFIE---------NIEKVAAPFRSSYW----------------
-----------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------MATPT-YKSLLQL--SQNALISPWKGQLIIQ
GCLLCDITLWSTHGTGIPVQLPQELDFKYVMKVSSLKESLPEAAFGRQNYLEQKVCCQDL
CFDLY

PF12480 // ENSGT00530000063735_1_Domain_2 (426, 522)

EVELSNKQGENIDKLIRYIKNKQ--------------LAIIKCLEDGGFFILLTS
SALTPEPDF--GD-KQMGLHGLHLFHSP------QS-TGAK

ENSGT00530000063735_1_Linker_2_3 (522, 958)

DLKVE---DGISLKVIPIL
PALSHALLEAKKSLPEKGIPPNILVKHSFQDLFKVDKSLSLM-AL-RDEMKDTAFKGK--
-LSHAFDLAP-PLEKCPSESLTQLKSYFLDPSGYTLDLSAALDLLAEHPQCPC-ISDGIC
DAGFSLVMTPDPEFLDSEMELRKETETSKKSGKPLRVKKRAVALLTP-ASNLRVQP-KRK
ASTSAVM---------------------LPNKRVSLGRPLSKRTASKADSGS-CNPTLKL
VKGQFPQKRKR-GAEVLTAQFVQKTRLDRKKQEA--SVSKDAPVATNAKRAKKQEKSPGR
VVSRPKPSVKKSTQKRKVNVARGRRNPRTRKQPQPAEKDIALHLQSEISSNGQIDGTNL-
STAQQESITVI-PKGFPENSIVNCDSQALNMLADLALSSAASS-IPSSELRTV----

PF12509 // ENSGT00530000063735_1_Domain_3 (958, 1130)

PCF
PELPQN-NVLLS-KENSLHGTTDHEYHRGVKNQKGILLPKPSSD------EKIDSKLDLP
FSQE-ENMVPCAQ---------PLAIAQPAPAEEARES---S--DASQNS-VAVEHSYAL
LLAEQSKKHL--HQRKLPSPAFAKNGAKGPEAGTPIGKVMPFRHLQNTS

ENSGT00530000063735_1_Linker_3_4 (1130, 1290)

PLQKRSEDSLT
KRKSLFVSSSIKDVFC-SHTVLSCDGSFKITFKCEGEYAFNLDSKYTSNSLEKTVVRALH
GPWNTDLPENMEDVKLLLHMWVALFYSKKNKIMGSPRKVVEHRNPAKYVCINRSVESFDQ
SEI-EEFSSVERYS----IDHLLETKEAY

PF12509 // ENSGT00530000063735_1_Domain_4 (1290, 1569)

EGHATNMTFPGPNCVLPFISPPTTRDLELCV
QNEQKEMFTGECH-LDTSGSQNFTY-SCNNE---VTGGKDKQELPCIPETSNVG-LSGVT
SAQSNGSCIPSEDKTLQS---TKM-----------------VSCNDSVTQATL-----TT
TYEGARSESM--------------------------------------------------
--------------------------------------------------------MCQK
------SVVGNLE-----NKDDTLHPSLLK------KTGAVQDVIHHSSPVN-NNYTPSV
ERT-DDDVEYMMINLEPVTL----------------------AFEKTAYIPIHK------
-EVNTADKPTGFNTELVKQVSSALSIQYSLSTLEKAQTE-------CPRDIPSLAISEYK
ASKCLSASSLKKKTPP-ESLGPLQKEIPP-PT-SA--DEGLITEALPLV-----KSSSYS
LANDKTKCPQDSFLQTQNGFRMSLDEVLEPSQVKA-SS-PTSATLG--KKQSLNCIPAIS
NVSDDSSEVRNNDKSSLNQEK-ALQTFNSLFP-KQTDLSMNKEEVSRKL--SGEDSDIDL
TLTVSPHPSSREEMAAGEIKQLQRA-PISNLGLQSRTEEMVEPEA-------QVSHIKNE
EISSASFMSVFPVEPRE-------------------------------------------
-PLKET--QSSDLKPGTLILSKENCSPEVTEEINVPSGFPF-GPLIEEVSPASSPDPIVQ
TEETQPS---------PCCLKPHGAESEKSSNFSQIKSGDLTIPE-------KGNSFVG-
PKPSMGQDKLPQVQ-VQISAEMPQIL--NNAGIEG--RVTV---PGEITEFSVPS-----
---------------------------------------EHNE-----NLSFSEKVQCY-
DT-ELS---------------------------KSTS-P---PKYRGNF---K-PLEK--
----LIESGNPLQAVCMENRNLDIKPFALE-SIVPSCSPRKVVENKSLADTLVSVTTVNA
IVDMSLK-------------------E-TSSKKN-KNICDSDLKT------EGDTNKQAG
SVNSASIDKTDVV-PANMHPEISNFVSSSDHA-QCTYFTKPVSVEPGFQTQEIQ---TSS
LLQNVG--TELHEERMDLSAIGLHSNSTS-TKGEQKTIHVLQDTSKCEEEKPL-------
--------NDGISP----QNA--HSSQNTADISKSIN-EEPSASFVTESV-NS-----VC
GVYKEHIVSENPNMGHKTK--ADSETLSRNTEISV----NASMCYGPLSEDTDQD-SL-D
CRN-CKLDSENL-CTLRGCHANQ-KDAVKDSNDSFTGL----NISDNNTWVYSN--KISE
LETHIPCRSWD--TELCP-ISTN-KCMPRYVQIPDSHGIPRTYANFTISKESRDTTRTL-
HSLKRHRNFTANCGLLSSWTSTWH-VADDLTQNTLDLEYLRFDHKLKQIVKK-VDSQQAS
PNTSSFSEESLIQISVRTHPSTQTADASLL-RLPAKSRSPILVTVGHSDTR---QQS-HR
RRSHSPSNLDS--SSFFWREQCSQS--RN-LKNSE-RSHTVPVHLNKLKYNS--TLKEGR
NDISLILNEYAEFNKVMMNSDQIVSQ-EKELSVA-SAEAV-SQE--TCQPRQSVSYKDVI
TDLCATLHIKLKGVMREACKSPFWFYLVETE-DKSFFLRTKSILKKGGHSEIELLDFCQA
FQGENE--TLLVIIKNEDIMSHLHQIPSLLKLKHLPSVIFAGVDSPEDILNDTYQELFRS
GGFVVSDDNILESLTLVQLKEIVTILEKLNE--NGRWKWLLHYRENKKLKEDVRVDSIAH
KKNLILKSYQSVNIIELLHYHNCDSPSPTKAENLKCLLNLQVQHISARFAVFLTDKPTV-
-STEVFENNGILVTNVNYFTE---------NIQKIAAPFRSSYW----------------
-----------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------MAAPT-SKIILEL--NKNALISPWKGQFIIQ
GCLLCDITLWSTYGTVVPLQLPRELDFKYVMDVSSLKESLPEAAFRRRSYLEQKVCCQDL
CFDLY

PF12480 // ENSGT00530000063735_1_Domain_2 (426, 522)

EVELTNKQGENIDKLMEYVKNKE--------------LALIKCLEDKSFFILFTS
SALTPEPDF--GA-EQMGLHGLHLFHAP------QT-AGAK

ENSGT00530000063735_1_Linker_2_3 (522, 949)

DLKVE---DGISLKVIPIL
PALSYALLEAKKSLSEEGIPPNILVKHSFQELYKVDKSLSLM-APPQDGVEDTASTGK--
-LSHAFDLPP-PLETCPSESLTHLKCYFSDPAGYTLDLSAALDLLAEHPQFPG-ISDGVC
DAAFSLVMTPDPEFLDSEMEIRK-TETAEKSGRKLKVKKKAVTP----SSNQRVQP-KRK
ASTTAVT---------------------LPSKRVSLGRPTSKRTVPRTDNRS-CNPTLKL
VKGQFPQKRKR-GAEVLAAQIVQKTRLERKKQEA--SVSKDAPVPTNTKRAKKQEKSPGR
IASQPKPPMKKSPQKRKVNVARGRRNT--RKQLQPAEKEIALHLQSEISSDGQKDGLNL-
STSQQESISMI-PKGPPENSVISCDSQALNMLADLALSSAAAS-IPSC

PF12509 // ENSGT00530000063735_1_Domain_3 (949, 1130)

KPRNL----PCV
SDLPRN-NVLLT-KENPLLGASDHEYHKGVKSQKAVLLPKPYSD------EKISSESDLT
RSQE-ENLVPCAQ---------PLPIAQSAPHSEAREL---S--DASQNS-VVVEHSYAL
LLAEQSQKHL--HQRKLPSPAFVKNGIKGPEAGTPVGKVMPFRHLQNTSPLQKHSEDSLM
KHKSLFVSSTLKEFFC-SHTVLKCDGSFKITFKCEGEYVFSLDSKYTSNPLEKTVLRALH
GPWNTDLPENVDDVKLLLHIWVALFYSKNNKVIGSPRKVVEHKNPAKYVCINRSLESLDH
SEI-EAFSNVERPSVEGSVDPLLETKETHIGHATNMTFPGPNRVLPFINPPTTRDLELCV
QNDQKEVFTGECH-LDTSGNQNFIY-SCNTE---VTGGKTKQELSNKLETSNVV-LSGVV
SAQSHSTCIPSEDKTCQS---TKM-----------------VSYNDSVTQATL-----TT
AYDEASSELMCQKSVFDNLENKVDS-----------------------------------
------------------------------------------------------------
-----------------------FHPSPLI------KTDAVQDVIQHSSHIN-NECQPSV
EKR-EDNVECMMVNLDPVTL----------------------AFEKNASVPIHT------
-EVHTTDKPTGFNIELVQRVSPASSVQYPMSALEEVQTQ-------SSRDVPSLAMSEYK
DSKCLSASSVKKETPP-ESLCLLQKEIPS-LTSSA--DEGLIMEALSLV-----KSSSYS
LASDKTKCPQDTSLQTQNGLSMSLDEVLEPSKVNV-VS-STSVTLR--EQQSPNCIPAMS
DVAGASTVIMNSGSSSLNQEK-ILQTFSLVFP-KQADLSLKREEVSMEL--SGEEADINL
TLTISPPTSPSEEIAAGEIEQFQKT-PVSNVGQQSRSEEMVEPEE-------EERLIRNR
EINSASCMSVYPVESRE-------------------------------------------
-LLK-------------------NCTPEVTEKVNVTLDFPF-GPLIE-VSPASSPDPIVQ
PGDRQSS---------PCCLKLHSSQSEKTNKFSQIKSGEVTIPE-------KESLFLG-
PESPKGQDKLAEVQ-VQISAEMLQIT--TNAEVEG--RVNM---PGKVTKVSVPS-----
---------------------------------------EHSE-----NLSFLEKVQCN-
-T-ELN---------------------------KLSL-P---AKYGGNF---K-PLEK--
-------SGNSLEAGCMENRNMDVKHLALE-SSVPSCSPRKVVENKSLTDTLVSIT-TSG
IVNMSLK-------------------Q-TSSKNIKKNVCDSDVKTDSDVKTEAVSNMQTE
AVNSALIDKTDVQ--AYSHPEVSKFVSSSDSA-QCTYHAKPVSVEPGFQTQEIPVVRMAS
LLKNIG--VELHEEKMDLSATGLQSNSMS-AKDEQKTMHVLQDT-ICEVKEFL-------
--------NGDVFS----QNAH--SCQNTVDFSKSIS-EEPSASFVPEFV-DA-----IC
GVCKEHTFSESPDMVHETK--ADAETLSRNTEISV----NASMFCGPRSGAYVQD-SH-D
CKS-CKFDVEN----LRGNHESQ-KDAVKDSCDSFTSL----NNSD-DTWACSS--KIST
LETHIPPRNQE--TEPRL-ISPN-KCIPRYIQIPDSHGIPKTYANFTITKEFKDTTRRL-
HSLKRHRNLSANCNLLSSWTSTWH-VTDDLTQHTLDLEYLRFDHKLKQIKK--GGSQQ--
---SSFPKESLVQISSGTSPSTQTSEASGL-HLPPESRSPILVTVVRADTR---QQS-HH
RRGCSPSSLDG--SSSFWKKKCSQS--RN-LKNSE-RSQTVPFHLNKLKYNS--TLKESR
NDISLILNEYAEFNKIMMNSNQIVSQ-DEELNIA-SAEAV-FQE--AYQPRQSVSYEDVI
TDLCATLHVKLKGVVREACKSPFWFYLVETE-DKSFLLRTKSILKKGGHIEIELLDFCQA
FHRENE--TLLVIIKNEDIISHLHQIPSLLKLKHFPSVVFAGVDSPEDIVNDTYQELFRS
GGFVVSDDVILESLTLVQLKEILKILEKLNE--NGKWKWLLHYRESKNLKEDVRVDSIAH
KKNLILKSYQSVNIIDLLHYHNCDSPSSTKAEIFKCLLNLQIQHISARFAVFLTDKPTV-
-STEIFENNGILVTDVNYFTE---------NIQKIAAPFRSSYW----------------
-----------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------MAPPA-HKSILE--RSENVLMSPWKGKLIVQ
DRMLCDIALWSTYGAMIPTQLPQELDFKYVMKVSSLKKRLPEAAFRKQNYLEEKVCFQDL
CFNLY

PF12480 // ENSGT00530000063735_1_Domain_2 (426, 522)

EVELSNRQGENIDKLTECIKNKQ--------------LAIIKCLEDRGFFILLTS
SALLSEPDF--GG-KQMGLHGLHLFRSP------LS-TGVK

ENSGT00530000063735_1_Linker_2_3 (522, 949)

DLKVE---DDISMKVIPIL
STLNCALLETKKSLPEERIHPNTLVKRHFQELYKADRSPSLS-VAPQDRMKDPTFLGK--
-LPSGFDLIP-PAEKCPSESLTQLNSYFSDPSAYILEVSTALDLLAEHPQSPC-VSDGIC
DAGFSLVMTPDPEFLVSEAEVRKETETKKDSEEMLKAKKR-VFPLSP-ASNLRVQP-KRK
ASMPHMV---------------------Q-SKKVNLCRPFPKRTASRADNSSDSPTTLKL
VKGQFPQKRKR-GAEVLTAQFVQKTKLDRKNQEAP--ISKDVPVPTNAKRARKQEKSPVK
TVPRAKPPVKKSPQKQRVNIVKGNENPRNRKQLQPVKGETASKLQSEISRGCQEDGISI-
NSVQPENTTAA-HNDLPENSIVNYDSQALNMLADLALSSATSS-TPVS

PF12509 // ENSGT00530000063735_1_Domain_3 (949, 1125)

EARNL----HCS
SELPQN-DVLLS-KENSLRGTSDHEYHRGVKTQKGELLPNPSSD------RKSNSGSDLT
VSQDEESLVPCSQ---------APAKAQSALTEEMLES---S--DASQSSSVSVEHSYAL
LLTEHSKKHL--QEREILSPLFPRNGTKSPEAATPVGKVMPFRH

ENSGT00530000063735_1_Linker_3_4 (1125, 1287)

QPGLLLQQKPPDDPVV
KPKDRPPSARVKKSSC-SRIVLSCDDSVKITFKCETEYAFSLDSKYTNNPLEKTVVRALH
GPWNTDLPDNVEEVKLLLHMWVALFYSNQNKIIRSSRKVVEHSNPAKYVSINSTLESCEL
REI-EESLGLEKCS----ADSLLETN

PF12509 // ENSGT00530000063735_1_Domain_4 (1287, 1583)

EISRAHAAEVSFRDPNCLLPFIKTPLTQGLELCV
QNEQKKTFARECD-PDTQEDQNF-ICSYNNE---VTGEEAKQE---SLETSNLV-LSGIG
STQTNGPSVPSEEEIVQPLDSTRV-----------------ASYSGTVTQATF-----TR
TYDGPGSQPV--------------------------------------------------
--------------------------------------------------------ICQS
------SVYGTLE-----NKVDILDAAVQT------KTGTLQDLIQHGSPIN-NECHPSL
ERK-DDNMGCAVINPEPITL----------------------TFEKNAHVPIQT------
EGVNTADERTTFKKELIKQVSPAASLRHPVSTSENARTQ-------GLRDIPSLVVAGQK
GTKYLCASSVGGETLD-KAVCSLQKETPL-PV-SLPSDKTMVMEALSLA-----KSSSHL
SPSEEVRCTQDFLSQTQSLLGLSSEGLLELTQVEV-DSSSASTTLG--RQCSLNCISSGC
HTSGDSLELRKNHKNGPNTENMNLEAFDSVFI-KQTSLSVSR-EVSLEL--SEEDSDIDL
ALTISPPTSPREEMPAGEIEQFEEA-PFSNLELQDVAEEIG-EPE-------EVALTESR
EVSSADNVSVYPSVSEE-------------------------------------------
-PVENKERKGDNLQPVTLILSKENCTLEIAEEINVTSDFPF-DSVIEEVSPASSPEPPVP
VKETRPY-----QAVTPCILKLHGTQCEKSNQISQCESEDLGITE-------KENVFVG-
PTHPVGQDNFTQVQQMQVSAEMPLIL-TDHPGRTG--RPTL---PGKVTEEIVSS-----
---------------------------------------EHDE-----GLSFSGKVQCY-
GRE-LN---------------------------QPAS-A---AKCTGDF---SPSPEK--
----LVKSGNPLQPVSIENRNLDLKHLVLE-SSEPPFGPRNVIENKSLSDTLVSTTAPSG
IVNVSVK-------------------QQTSPKSSQNHLFPGDLKT------DEGIYLQVK
SLTAASVDGAYST-QGCMCSVVPTLCSSSDNA-TLTHYVRPINAEPVFQAQEIPAGRMAS
LLKNGEPEAELHKETTGPGTAGPQSNTTSSLKGERKAIHTLQDVSTCETKELL-------
--------NVGVSS----LCAG--PYQNTADTKENLS-KEPLASFVSESF-DTS----VC
GIATEHVEIENSGEGLRAE--AGSETLGRDGEVGV----NSDMHYEL-SGDSDLD-LLGD
CRN-PRLDLEDS-YTLRGSYTRK-KDVPTDGYESSLNF----HNNNQEDWGCSS--WVPG
METSLPPGHWT--AA----VKKEEKCVPPYVQIRDLHGILRTYANFSITKELKDTMRTS-
HGLRRHPSFSANCGLPSSWTSTWQ-VADDLTQNTLDLEYLRFAHKLKQTIKN-GDSQHSA
SSANVFPKESPTQISIGAFPSTKISEAPFL-HPAPRSRSPLLVTVVESDPR---PQG-QP
RRGYTASSLDS---SSSWRERCSHN--RD-LRNSQ-RNHTVSFHLNKLKYNS--TVKESR
NDISLILNEYAEFNKVMKNSNQFIFQ-DKELNDV-SGEAT-AQEMYLPFPGRSASYEDII
IDVCTNLHVKLRSVVKEACKSTFLFYLVETE-DKSFFVRTKNLLRKGGHTEIEPQHFCQA
FHREND--TLIIIIRNEDISSHLHQIPSLLKLKHFPSVIFAGVDSPGDVLDHTYQELFRA
GGFVISDDKILEAVTLVQLKEIIKILEKLNG--NGRWKWLLHYRENKKLKEDERVDSTAH
KKNIMLKSFQSANIIELLHYHQCDSRSSTKAEILKCLLNLQIQHIDARFAVLLTDKPTI-
-PREVFENSGILVTDVNNFIE---------NIEKIAAPFRSSYW----------------
-----------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------MAAPP-HKSILE--SSKNVLISPWKGKLTIQ
GCVLCDITLWSSYGTVIPAHLPHELHFKYVMRVSSLKERLPEAAFRKQIYLEQKVCCQDL
CFNLY

PF12480 // ENSGT00530000063735_1_Domain_2 (426, 522)

EVELSNKQGEEVDKLTEYIKNKQ--------------LALIKCLEDRAFFILLSS
SALIPEPDT--GD-EQMSLHVLHLFHSH------LA-TEVK

ENSGT00530000063735_1_Linker_2_3 (522, 949)

DLKIE---DDISWKVAPIL
PALNCALLEAKKLLPEEGTHPNILVKHNFQELNKVDKNLSLT-AAPQDVKKETTFFRK--
-LSGSFDLVP-PPEKCSTESLTQLKSYFSDPGGYTLEVSTALGLLAECPPSPY-ISDGIC
DAGFSLVMTPDPEFLDSEAEVRKKTQTEKSSEEMFKEKKGAVVPLSA-ASNLRVQP-KRK
ASMLPIV---------------------R-SKRVNLCPSFAKRTTPGTDSRSSSPSPLKL
VKGQLPQKRKR-GAEVVTAQVVQKTKLNRKSQEVP--ISKDVPVATNTKRARRQEKSPIK
TVPRAKPPVKKSPQKRRVNIVKGSQNPRIGKQPQPAKEETALQLQSEISSDGQKDGISM-
NTAQSQSITVA-QKDLPENSIINYDSQALNMLADLALSSAASS-TPLC

PF12509 // ENSGT00530000063735_1_Domain_3 (949, 1130)

EARNL----PCS
SELPQN-DVLHS-KESSLCDTSDHDYHSGVKSQKGILLSKSSCD------QKSNSGLDLT
ASHEEENLVPCSQ---------TPPNAQSALREE-TEP---S--GTSQNSLITVEHSYAL
LLGENSKKHL--QQRGLPGPAFAKTGTKGPEAGTPVGKVMPFRHLQNTS

ENSGT00530000063735_1_Linker_3_4 (1130, 1287)

PLQKLSEDSLV
KHRGRFISSNLKNIFC-SHTIISCDGSFKITFKCETEYAFNLDSKYTNNPLEKTVVRALH
GPWNTNLPDNMEEVKLLIHMWVALFYRNRNKVIQSSRKVVEHSNPEKYVSINSTLESFEL
SEI-EESSSVERCS----IEPLLETK

PF12509 // ENSGT00530000063735_1_Domain_4 (1287, 1572)

EMSRAHANEVSFHGPKCLLPLIKLPPSRGLELCV
ENERKEIFARECH-LDNSESQNFIH-SCNDE---VVGGKAKQESANKLEASNLV-LSVIG
NTQTNGPFSSDEDETFQSVDSKRV-----------------VSYNDTGTQATF-----TR
TYDGASSQSE--------------------------------------------------
--------------------------------------------------------MCEK
------SVYIPLE-----SRVDILHTTVQT------NTNALQDLIQCSSPIN-NECESSL
EKT-DDNMEYVMINLEPVTF----------------------TLEKDACVPVHT------
-EVNRGEKPLPFSSELINQMLPAADVRHPISALEEAQTQ-------AVRDIPSLAMAGQK
STKYLSASSGKREILD-EELLLSQKEMTL-PVSSPSSDKALIMEALSLV-----KCSSYP
LPSEEMKHSQDICLQTQNLFSISSEEIIEPSQIEV-VSPSVSASLG--KRYSNDCVPPKT
NIPDDSLELRKNDKSSLNCENVNLESFNAVFA-KQTNLLINGQEIGLEL--QEENSDIDL
TLTISPPTSPRGKVPANETKQLQEA-TGSNLELKDIAEEII-EPK-------EVTLIEKT
EENPASSMSAYSTVSKE-------------------------------------------
-PLEN-ERKGDSLQPITLILSKENCTLEIGEEINVTSDFPY-GSLIEEVSPSSSPDPLVP
IEEARPS-----QVVSPCSLKLHGTQCEKSNKFSQIESEDIAVTE-------KENSFVD-
PSHLVRQENTTQLQQIQLSVKMPLIL-TNHPGRKG--RLMF---PGKITEEIVPR-----
---------------------------------------EHGE-----GLSFSEKVQCY-
GT-ELN---------------------------KPGL-I---ANYGDNF---KPSLEK--
----LVKSGNPLQPISIENRNLGLKHLVLE-SHEPSFSSRKSIENKSLAEALVSTTSLSG
IVNIPLK-------------------EQGSPESIKEKLCNSDLKT------DGGSYMQVK
SVSSVSIDEADVT-QAYLHPEIPEFGSASDSA-TFTQCTRPESIEPGFQTQEIPVIRMAS
LFGNSRTEAELHEEGTDVDAISLQSNSTASTKGEEKTVHTLSDTSVCEMKELL-------
--------KGEFMP----TYAC--SYQSTIDTSE----EP--SAFVSESI-ETL----VY
GVSKEHIDRKTTSEGHRNE--ADAKILDRNVDANM----NSDKHYEPLSGDSDQD-SFNN
CRN-PRLDMENS-GILG-SYTSKNEHAAKDGYYSLMCL----NNSDNEACDYSN--KVPG
VKMNIPPRNWA--TG----LKKADECMPHYVQIRDRHGILRTYANFTVTRELKDMTRTL-
HRVRRHPSFTLNSDL-SSWMSTWQ-VADDLTQNTLDLEYLRFTHKIKQLVKKEGSRQ---
-------TDSPLEILLRDFPLTEKSEPPVL-HPTPRNRSPILVTVMHTDARW---QS-CH
RSGHTPSDLDS--SSSFWKERCSHS--RN-LTNSQ-RKQTVSFHLNKLKYNS--TLKESR
NDISLILNEYAEFNKVVMNSNYADFQ-DKELNMA-SEEAT-FQETYPSFSRQSTSYEDII
TDLCASLHTKLNSVLKEACKSPFFFYLVETG-DKPFFLRTKSILRKGGHTEIEPQHFCHT
FHREND--TLVVIIRNEDISSHLHQIPSLLKLKHLPGVIFAGVDNPEDVLNDTHQELFHT
GGFVVSDDKILETVTLAQLKEIVKILEKLNG--NGRWKWLLHYRENKKLKEDVRMDSVAH
KKNLILRSYQSANIIELLPYHQCDSQSQTKAEILKCLINLQIQHVDARFAVFLTDKH-I-
-SSEVFGNNGILATDVNNFIE---------NIQKIAAPFRSSYW----------------
-----------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------YFL-FLSRLERSLNKNALTSPWKGQLIIQ
GCFLCDITLCSTYGTVIPVQLPRELDFKYVMKVSSLKESLPEAAFRRQNYLEQKVCCQDL
CFDLY

PF12480 // ENSGT00530000063735_1_Domain_2 (426, 522)

EVELSNKQGENIDKLIEYIKNQQ--------------LAIIKCLEDREFFILLTS
SALTPEPDF--GD-EQMGLHGLHLFHSP------QS-TGAK

ENSGT00530000063735_1_Linker_2_3 (522, 950)

DLKVE---DDISLKVIPII
PALSCALLEAKKSLPEKGIPPNVLVKHSFQDLYKVDKSLSLM-AP-QDGMRDTAFIRK--
-LSYSFDLAS-PDEKCPSESLIQLKSYFSDPTGYTLDLSTTLDLLAEHPQSPC-ISDGIC
DAGFSLVMASDPEFLDSEMEVRKETETTKKSGKMLRVKKRAVAPLTP-PSNLRVQP-KRK
ASTSAVT---------------------LPNKRVSLGRPLSKRTAPRADSGS-CIPTLKL
VKGQFPQKIKR-GAEVLTAQFVQKTRLDRKKREV--SVSKDAPVATNAKRTKKQEKSPGR
VVSRPKPPVKKCPPKQKVNVTRGRRNSKTRKQLHPAEKDITLHLQSEISSNGQKDGINL-
STAQQESIAMI-PKGFPENSVINCDSQALNMLADLALSSAVSS-IPPCE

PF12509 // ENSGT00530000063735_1_Domain_3 (950, 1130)

LRNL----PSV
SELPQN-NVLLS-KENSLHSTSDHEYHRGVKSQKGVLLTKPSSD------EKLNSESDLP
VSQE-ENLVPFAQ---------FPTIAQSVPPEEGQES---S--DASQNS-VAVEHSYAL
LLAEQSKKHL--HQRKLPSPAFAKNGAKGPEAGTPIGKVMPFRHLQNTSPLQKLSEDSLT
KRKSLFVSSSLKDFFC-SHTVLSCDGSFKITFKCEGEYAFSLDSKYTSNPLEKTVLRALH
GPWNTDWPENMEDVKLLLHMWVALFYSKQNKVMGSPRKVVEHRNPAKYVCINRSIESFDQ
SEI-EEFPSVEQYS----ENSLLENKEACEGHATNTTFPGPNCMLPFVNPPTTRDLELCV
QNEQKEIFTGESH-LDTSGSQNFIH-SCNNE---VTGGKDKQELSDIPETSNVG-LSDVT
RAQSNGSCIPSEDKTLPN----------------------------------------TT
AYDGAGSEAM--------------------------------------------------
--------------------------------------------------------MCHK
------SVLSTLE-----NKVDTFHPSLLI------KTGAVQDAIQYSSPIN-NKCQPSA
QRT-DDNVEYM-INLEPVTL----------------------VFEKAACVPIHT------
-EVNTADKPTDFNTELVKQVSPALSIQYPVSELEEAQTQ-------CPRDIPSLAISEYR
ESKCLSASSLEMETAP-ESLCPLQKEIPP-PTS----ADGLITEALPLV-----KSSSYS
LASNKTKCPQDASLQTQNGFSMSINEVLEPSQVKV-VSSSTSATVG--NKPSLNCIPAIR
NISDGPSEVRINDKSSLNQEK-TLQILNSVFP-KQADLSMNREEVGMEL--SGEYSDTNP
TLMVLPPTNPREEMAAGKIEQLQKT-PVSNLGLQSRTEEEVEPEV-------QVSLIKNK
TINSASYISVYAVDPRE-------------------------------------------
-PLKET--Q-------------KNCAPKVAEEINIPSDFPF-GTLIEEVSPASSPDPIVQ
TEETQPT---------PC-LKLHGTQSEKSSEFSQVKSADLTIAG-------KENSFVG-
PKTSMGQNKLTQVQ-VQLSAEMPQVL--TSAGIEG--RVTV---PGEIAEFSVPS-----
---------------------------------------EQNE-----SLSFSEKVQCH-
DI-ELN---------------------------KPTS-P---PKYGGNF---K-PLGK--
----LLKSGNSLQAICMENRNLGIKPFALE-SIVPLGSTRKIVENKSLADTLVSIPSVSE
IVNMSLK-------------------H-TSSKNSKKN--SSDLKT------VADINMQPG
SMNSASIDKTE------------EFVSSCDSA-QCTYYKKPASVEPGFQTQEIPVVRMAS
LLQNIG--TELREERMDLSAVGLHSHSTS-TKGEQKTICVLQDTLKCEEKKPL-------
--------NDEVFS----QNV--RSYQNTADISKSIN-EEPSASFVPEPL-DS-----VC
DIYKEHTASENPNMGHKPK--ADSKALSRSTEISV----NASTCYEPLSGDTDPD-SL-D
CRN-CKIDVENL-CTLGGSHASH-KGAVKDSSDSFTSL----NNS--DTWINSS--KISE
LETHVPPRSGD--TESCP-ISTNDKCMPRYVQIPDSSGISKTYANFTITKESKDTTRTL-
HSLKRHWNFTANCNSLSSWTSTWH-VTDDLTQNTLDLEYLRFDHKLKEILKK-GDSQPSS
LSTNIFPKESLIRISVETCPSTQTSDASLL-HLPPKSRSPVLVTVVHSDTR---PQS-HR
RRDHSPSNLDR--S-SFWKEKHSQS--RN-PE----RNQIIPVHLNKLKYNS--TLKEAR
SDISLILNEYAEFNKVMMNSNQTVSQ-DKELNVA-SAEAC-PQE--TYQPRQSVSYKDVI
TDLCATLHIKLKGVMREACKSPFRFYLVETE-DKAFFLRTKSILKKGGHTEAELLDFCQA
FQRETE--TLLVIIKNEDIISHLHQIPSLLKLKHFPSVIFAGVDTPEDILNDTYQELFRS
GGFVVSDDDILENLTLVQLKEIVKILEKLNE--NGRWKWLLHYRENKKLKEDVRVDSVAH
KKNLILKSYQSVNIIELLHYHNCDSPSPTKAEILKCLLNLQIQHISARFAVFLTDKHTA-
-SPAVFENSGILVTDVNYFTE---------NIQNIAAPFRSSYW----------------
-----------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------MAPPA-HKSILE--RSENVLMSPWKGKLIVQ
DRMLCDIALWSTYGAMIPTQLPQELDFKYVMKVSSLKKRLPEAAFRKQNYLERKVCFQDL
CFNLY

PF12480 // ENSGT00530000063735_1_Domain_2 (426, 522)

EVELSNRQGENIDKLTECIKNKQ--------------LAIIKCLEDRGFFILLTS
SALLSEPDF--GG-KQMGLHGLHLFHSP------LS-TGVK

ENSGT00530000063735_1_Linker_2_3 (522, 949)

DLKVE---DDISMKLIPIL
PALNCALLETKKSLPEERIHPNTLVK-HFQELYKADRSPSLT-VAPQDRMKDPTFLGK--
-LASGFDLIP-PAEKCPSESLTQLNSYFSDPSAYILEVSTALDLLAEHPQSPC-VSDGIC
DAGFSLVMTPDPDFPGSEAEERKETETKKDSEEMLKAKKRVVVPLSP-ASNLRVQP-KRK
ASMPHVV---------------------Q-SKKMNLCHPFPKRTAPRADNSSDSPTTLKL
VKGQFPQKRKR-GAEVLTAQFVQKTKLDRKNQEAP--ISKDVPVPTNAKRARKQEKSPVK
TVPKAKPPGKKSPQKQRVNIVKGNENPRIRKQLQPVKGETASKLQSEISRDGQEDGISI-
NSVQPENTTVA-HNDLPENSIVNYDSQALNMLADLALSSATSS-TPVS

PF12509 // ENSGT00530000063735_1_Domain_3 (949, 1125)

EPRNL----HCS
SELPQN-DVLLS-KENSLRSTSDHEYHRGVKSQKGELLPNPSSD------RKSNSESDLI
VSQDEESLVPCSQ---------APAKAQSALTAEMLES---S--DASQSSSVSVEHSYAL
LLREHSKKNL--QEREIPSPVFPKNGTKSPEAVTPVGKVMPFRH

ENSGT00530000063735_1_Linker_3_4 (1125, 1287)

QPGLLLQQKPPDEPMV
KPKDRQASSRVKKSSC-SRIVFSCDDSVKITFKCETEYAFSLDSKYTNNPLEKTVVRALH
GPWNTDLPDNVEEVKLLLHMWVALFYSNQNKVIRSSRKVVEHSNPAKYVSINSTLESCEL
SEI-EECLGLERCS----ADPLLETN

PF12509 // ENSGT00530000063735_1_Domain_4 (1287, 1583)

EISRAHAAEVSFRDPNCLLPFIKTPLTQGLELCV
QNEQKKTFARKRH-PDTLENQDF-VCSYNNE---VIGEEAKQESLDKLKTSNLA-LSGIG
STRTNGPSVPNEEEIVQPLDSTRV-----------------ASYSGTVTQTTF-----TR
TCDGTGSQPV--------------------------------------------------
--------------------------------------------------------ICQS
------SVCSTLE-----NKVD

ENSGT00530000063735_1_Linker_4_5 (1583, 1664)

VPDAAMQT------KTGTLQDLIQHGSPIN-NECHPSL
ERE-DDNMECAMINPEPVTL----------------------I

PF12480 // ENSGT00530000063735_1_Domain_5 (1664, 1717)

FEKNAHVPLQT------
EAVNTADEPTTFNKELIKQVSPAASLRHPVSTSEKAQTQ-------GLRDISSLVVAGQK
GSKYLCASSVGRETLD-KEMCSLQKEMPL-PV-SLPSDKAVVMEALSLV-----KSSSYL
LPSEEVRCTQNFLSQTQSRLSLSSEGLVEPTQVEV-DSSSASTALG--KQCSLNCISSGC
HTSGDSLELRKNDKNGPNTENMNFEEFDSVFI-KQRRLSVSR-EVSLEL--PEEDSDIDL
ALTISPPTSPREEMPAGEIEQFEEA-PFSNLELQDVAEEIG-EPE-------EVAVTESR
EVNSADSVSVYPTVSEE-------------------------------------------
-PVENKERKGDNLQPVTVILSKENCTLEIAEEINVTSDFPF-DSVIEEVSPASSPEPPVP
VKETRPY-----QAVTPCILKLHGTQCEKSNRISQRVSEDLGITE-------KENFFVG-
PTHPVGQDNFTQVQQMQVSAEMPLIL-TDHPGRTG--RPTL---PGKVTEEIVSS-----
---------------------------------------EHDE-----GLSFSGKVQCY-
GRE-LN---------------------------QPAS-A---AEYTGDF---SPS-EK--
----LVKSGNPLQPIRVENRNLDLKHLVLE-SSEPPFSPRNVTENMSLSDTLVSTAVPSG
I----VK-------------------QQTSPKSSQNNLLTSDLKT------DEGVYLQVK
SLTTASVDGAYST-QGCMCSVVPTLCSSSDSA-TLTHYVRPINAEPAFQAQEIPAVRMAS
LLKNGETEAELHKEITGLGTAGPQSNTKSSLKGERKAIHALQDVSTCETKELL-------
--------NVGVSS----LCAS--PYQNTADTRENLS-KEPLASFVSESF-DTS----VC
GISTEHIEIENGGEGLRAQ--AGSETLGRDAEVSG----NSDMHYELLSGDSDLD-LLGD
CRN-AKCDLENS-CTLRGSYTRKKEDVPTDGCESSLNF----HN-NQGDWGCSS--QVPG
MEMSLPPGHWT--TR----VKKEEKCVLPYVQIRDLHGILRTYANFSVTKELKDTMRTS-
HSLRRHLSFTANCDLPSSWTSTWQ-VADDLTQNTLDLEYLRFAHKLKQTIKN-GDSQHSA
SSANVFPKELPTQISIGAFPLTKISEASIL-HPAPRSRSPLLVTVVESDPR---PQG-QP
RRGYTASNLDN---SSSWRERCTHN--RD-LTNSQ-RNQTVSFHLNKLKYNS--TLKESR
NDISLILNEYAEFNKVMKNSNQVVFQ-DKELNNA-SGEAT-AQVMYLPFPGRSISFEDII
IDLCSNLHIKLRRVVKEACKSTFLFYLVETE-DKSFFVRTKNLLRKGGHTEIEPQHFCQA
FHREDD--TLIIIIRNEDISSHLHQIPSLLKLKHFPSVIFAGVDSPGDVLDHNYQELFRA
GGFVITDDKILEAVTLVQLKEIIKILEKLNG--NGKWKWLLHYRENKKLKEDERVDSTAH
KKNIMLKSFQSANIIELLHYHQCDSRSSTKAEILKCLLNLQIQHIEARFAVFLTDKPTI-
-PREVFENSGILVTDVNNFIE---------NIEKVAAPFRTSYW----------------
-----------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------MSTVA-RKNMVE--FDDEVLISPWKGQLIIQ
GQLICDLTLWSPHGAGIPTQLPRQLDAKYVMELSTLKKKLPESAFRKSNYLEKKVCYQGL
CF

PF12480 // ENSGT00530000063735_1_Domain_2 (423, 516)

SMYEVEISNKQGKKLDQLTEYIKTKE--------------LAIVKCLEDQGFLILLTS
SALLWDTDF--GD-EHMNLYALFLFPSS------S

ENSGT00530000063735_1_Linker_2_3 (516, 933)

S-TGRKESKGE---DDISMRVVPIL
PSLHYALLEAKKFLSEEEIHPNVLVKHHFQEFAKQNKNSSLP---FQNSFEEPEFFPCDT
LS-SELKSGLYS-EKCSQKTLTRLKSYFSDPSGYALEITTALDLLAGHSPSPFSASDGMC
DVGFSLLMPPDPEFVDSEAQVKNETDKNKNSDGTSKA-E-NTLQLCP-ASNLRIQP-KRK
ASMSVVM---------------------Q-NKKVNLCRPFSKKTGPVT----TIETTVKL
AKGQFPQKRKR-GAEVLTAQFIQTTKLDQKSQESF--VSESVPVVTNAKKVKKPETSPIK
TVPRVNQAMKKPPQKQKVNIVKSNQNPRMRKQLQPAKREIPSQPPIKILSNNQGNDHSE-
NTVQLGSPAVV-QSDVQENCIGHFDSQALNML

PF12509 // ENSGT00530000063735_1_Domain_3 (933, 1125)

ADLALSSATST-TSSSIHRDL----SSS
SDLTQN-NILFC-KENSLQSTYDHEYHRLAKNQRCALYSLELSKPSY---EQIDSRTSVP
DSQSEKNLTP-------YCQISVTQE---ALPKETVES---ADESNSNSSFIAIEHSYAL
LTAEHSKKHL--QQRGTQGPTFAKNGTKGPEAGTPVGKVMPFRHQHNTPPVQKLLLDPVI
KHKSRLLPSNLKEDFCHSHTVFSCDGSFKVTCKCETEYVFSLDSKYTNNPLEKTVIRALH
GPWNADVPDNVEEVKLILHMWVALFYSNQNKVIPSARKVVEHSNPAKYVSINSTLDPLDF
SEVGEECLGMKRHS----VESPLESNWNSSNSTTGILLACTNIKPSTSGLEERAALAGED
HQD----------VP---EFQSTI-CST-NE---VIRKRVEQELPSNIETPNVV-LSSNA
STQTREPSIADENENSQKLINSGA-----------------VSENGIIDQTMNCGTSVNR
ALENREDS------LYEALGTKAST-----------------------------------
--------------------------------------LQN-------------------
---------I-EHSSPRNKVTESQ--------------------------ES-------L
ENK-DGDLEYVMINLEPITF----------------------TFEKNACLPIET------
GFANGVDKIPDSDRELIKKVSPVESLRQQIPFREIAQAQNASSINQDLQDIPSMAPSVST
GTKYLCTSSVARETLA-KETGSLEKEVSI-PLSTSSANTVLIEAV------SSVVSSGDQ
ATSDEMKLPQDTFLQTPGLYSISSEEVIESAQVEEIVLTPTFAPMESKKTASAGYISSGA
TKLNYSLEK-ETNGSDLNSERMNFESVNVAFT-KETCISLGREAVSI-E--LSDDSDIEL
ALTISPPTSPRDQAQSDEIMQIQAV-PLENVELQVVAEEIIEPV--------TAFPKKRE
TN-SSDYSSLHTAV--------LPK------------------------------P----
--LENKECKRDALDPVTLVLAKEPCALEIGQEVNIITNSPFDGALIEPVSPASIPDEQVP
SKETPLS-----QDMPLQMLELHDTVSQEVSKASQMQ-------------SIDLS-----
----SGEEDHA--S----------DS-PGVPGEKP---TATQGKPTKLSSEM------AL
PLIDY-TEQKESLLLIHRRAAEDHVV-QNKYDDARFFQ---GK------------FQCC-
DTTLN----------------------------QTIS-AAECEDL-------KTSFQD--
----LERSENPLQQTSEEIKSLNSTHIVLD-THKSPPCLRKLIENRSVAEEIHSSTESNL
TSN-LLE-------------------HKNSPSDSKKDLHG----Q------SEYDYLPKS
SLDLTSVDQSDFI--CR-PSKNPDICINMDDA-SHISSSGQE-NEDTFQEHGISVSRVL-
--SNDEVISTLHEESINLKGTNLGSSLI-LSKGEGNTQVHQETSSVCETKDQS-------
---------SGIFATKESNLVCVGTYQNVANITKNTE-EEHSASIIQ-KP-WEA-----S
EELVEHE---SAGEGIGTE--KDIKSPDRNMDMNL----NTEIYYESLSGESDQE-CFGD
IKH-SQLQLDDP-CPLGTNHSNEVEEASVTDYDTLMDSRTITTSSDIESWNYSH--KSQE
ADKGTKQKSWS--T---G-FKKGDKYVPFYIKIRDLHGTPRTYTNFTVTKKLKDTTRTL-
HNLKQHPCVTARCGLISSWTSTWQ-VTDDPTQNTLDLEYLRFAHKLKQMVKN-GKSQLST
A-SSPLSKESHIQTTVGVFPLTKVTETPVT-HPTSRSRSPLLVTIVHSEPRQHTSS--WH
TNSEKHSDFNSLSSS-RQ-DKC-SQ--SRTVPNAE-RDPATSFHLNKLKYDS--KLKESR
NDISLILSEYAEFNKVMLNNSQRNYQ-ANDLSF--N-SGKTISPKITSFPRRMASYEHMI
TDLCSNLHVKLKNVIKEACKSTFLFCLVETE-DSSFFIRTRSLLRKEGHKEIEPQHFCQA
LHRETD--TLIVIIKNEDIATHVHQIPSLLRLKQFPSVMFAGVDSPGDVLDGTYQELFRT
GGFVVSDEKVLEAITLVQLKEIVKILEKLNT--NGRWKWLLHYRESKKLKEDVRVDSVAH
SKNSILKSYQSANIIEVLHYHQCDSKSSTKSEYLKCLLNLQVLRINARFAVYLTDKLNT-
-CREMFENNGILVTDINNFAG---------IVQK-AAPFKATYW----------------
-----------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------MAPPA-HKSILE--CSENVLMSPWKGKLIVQ
DRMLCDIALWSTYGAMIPTQLPQELDFKYVMKVSSLKKRLPEAAFRKQNYLERKVCFQDL
CFNLY

PF12480 // ENSGT00530000063735_1_Domain_2 (426, 522)

EVELSNRQGENIDKLTECIKNKQ--------------LAIIKCLEDRGFFILLTS
SALLSEPDF--GG-KQMGLHGLHLFHSP------LS-TGVK

ENSGT00530000063735_1_Linker_2_3 (522, 949)

DLKVE---DDISMKLIPIL
PALNCALLETKKSLPEERIHPNTLVK-HFQELYKVDRSSSLT-VAPQDRLKDPTFLGK--
-LPSGFDLIP-PAEKCPSESLTQLNSYFSDPSAYILEVSTALDLLAEHPQSPC-VSDGIC
DAGFSLVMTPDPDFPGSEAEVRKETETKKDSEEMLKTKKRVVAPLSP-ASNLRVQP-KRK
ASMPHVV---------------------Q-SKKVNLCHPFPKRTAPRADNSSDSPTTLKL
VKGQFPQKRKR-GAEVLTAQFVQKTKLDRKNQEAP--ISTDVPVPTNAKRARKQEKSPVK
TVPKAKPPVKKSPQKQRVNIVKGNENPRIRKQLQPVKGETASKLQSEISRDGQEDGISI-
NSVQPENSTVA-HNDLPENSIVNYDSQALNMLADLALSSATSS-TPVP

PF12509 // ENSGT00530000063735_1_Domain_3 (949, 1125)

EPRNL----HCS
SELPQN-DVLLS-KENSLRGTSDHEYHRGVKSQKGELLPNPSSD------RKSNSESDLI
VSQDEESLVPCSQ---------APAKAQSALTEEMLES---S--DASQSSSVSVEHSYAL
LLREHSKKNL--QEREIPSPVFPKNGTKSPEAVTPVGKVMPFRH

ENSGT00530000063735_1_Linker_3_4 (1125, 1287)

QPGLLLQQKPPDEPMV
KPKDRQASSRVKKSSC-SRIVFSCDDSVKITFKCETEYAFSLDSKYTNNPLEKTVVRALH
GPWNTDLPDNVEEVKLLLHMWVALFYSNQNKVIRSSRKVVEHSNPAKYVSINSTLESCEL
SEI-EECLGLERCS----ADPLLETN

PF12509 // ENSGT00530000063735_1_Domain_4 (1287, 1583)

EISRAHAAEVSFRDPNCLLPFIKTPLTQGLELCV
QNEQKKTFARKRH-PDTLENQDF-VCSYNNEPFQVIGEEAKQESLDKLETSNLA-LSGVG
STRTNGPSVPNEEEIVQPLDSTRV-----------------ASYSGTVTQTTF-----TR
TYDGTGSQPV--------------------------------------------------
--------------------------------------------------------ICQS
------SVCSTLE-----NKVD

ENSGT00530000063735_1_Linker_4_5 (1583, 1664)

VPDAAMQT------KTGTLQDLIQHGSPIN-NECHPSL
ERK-DDNMECAMINPEPVTL----------------------I

PF12480 // ENSGT00530000063735_1_Domain_5 (1664, 1717)

FEKNTHVPLQT------
EAVNTADEPTTFNKELIKQVSPAASLRHPVSTSEKAQTQ-------GLRDISSLVVAGQK
GSKYLCASSVGRETLD-KEVCSLQKEMPL-PV-SLPSDKAMVMEALSLV-----KSSSYL
LPSEEVRCTQNFLSQTQSLLSLSSEGLVEPTQVEV-DSSSASTALG--KHCSLNCISSGC
HTSGDSLELRKNDKNGPNTENMNFEEFDSVFI-KQRRLSVSR-EVSLEL--SEEDSDIDL
ALTISPPTSPREEMPAGEIEQFEEA-PFSNLELQDVAKEIG-EPE-------EVAVTESR
EVNSADSVSVYPTVSEE-------------------------------------------
-PVENKERKGDNLQPVTVILSKENCTLEIAEEINVTSDFPF-DSVIEEVSPASSPEPPVP
VKETRPY-----QAVTPCILKLHGTQCEKSNRISQRVSEDLGITE-------KENFFVG-
PTHPVGQDNFTQVQQMQVSAEMPLIL-TDHPGRTG--RPTL---PGKVTEEIVSS-----
---------------------------------------EHDE-----GLSFSGKAQCY-
GRE-LN---------------------------QPAS-A---AEYTGDF---GPSPEK--
----LVKSGNPLQPIRVENRNLDLKHLVLE-SSEPPFSPRNVTENMALSDTLVSTAVPSG
I----VK-------------------QQTSPKSSQNNLLTSDLKT------DEGVYLQVK
SLTTASVDGAYST-QGCMCSVVPTLCSSSDSA-TLTHYVRPINAEPAFQAQEIPAVRMAS
LLKNGETEAELHKEITGLGTVGPQSNTKSSLKGERKAIHTLQDVSTCETKELL-------
--------NVGVSS----LCAS--PYQNTADTRENLS-KEPLASFVSESF-DTS----VC
GISTEHIEIENSGEGLRAQ--AGSETLGRDAEVSG----NSDMHYELLSGDSDLD-LLGD
CRN-AKCDLEDS-CTLRGSYTRKKEDVPTDGCESSLNF----HN-NQGDWGCSS--QVPG
MEMSLPPGHWT--TR----VKKEEKCVPPYVQIRDLHGILRTYANFSVTKELKDTMRTS-
HSLRRHPSFTANCDLPSSWTSTWQ-VADDLTQYTLDLEYLRFAHKLKQTIKN-GDSQHSA
SSANVFPKELPTQISIGAFPLTKISEASIL-HPAPRSRSPLLVTVVESDPR---PQG-QP
RRGYTASNLDN---SSSWRERCSHN--RD-LTNSQ-RNQTVSFHLNKLKYNS--TLKESR
NDISLILNEYAEFNKVMKNSNQVVFQ-DKELNDA-SGEAT-AQVMYLPFPGRSISFEDII
IDLCTNLHIKLRSVVKEACKSTFLFYLVETE-DKSFFVRTKNLLRKGGHTEIEPQHFCQA
FHREDD--TLIIIIRNEDISSHLHQIPSLLKLKHFPSVIFAGVDSPGDVLDHTYQELFRA
GGFVITDDKILEAVTLVQLKEIIKILEKLNG--NGKWKWLLHYRENKKLKEDERVDSTAH
KKNIMLKSFQSANIIELLHYHQCDSRSSTKAEILKCLLNLQIQHIEARFAVFLTDKPTI-
-PREVFENSGILVTDVNNFIE---------NIEKVAAPFRTSYW----------------
-----------------------------------------

------------------------------------------------------------
MKKELTKSKS-----------MGKKLNSNLKSSGAAAAQ-------STVFETVSLSSDSV
FQRAVSILHTSYLDSASEHGFQYSQVTLVKNDIFLN

PF12509 // ENSGT00530000063735_1_Domain_0 (157, 316)

EYKTFYQQKKASDYTQEELQETYG
FLLFETENQAKLVCQRGLCVGSSAITTLGDPAKGVYISKYADYLHPRPWYHGKSGYV---
---VIFNLIKGKVKFVPENYTTNYTRPSSGYDCHVATNTNKVSHKTSHFRTFELSQYYVY
ELSGSTFIERPRQIC

ENSGT00530000063735_1_Linker_0_2 (316, 424)

PYVIVAFQYKEPKKMATPA-HKSILE--LNEDVLISPWKGKLIIQ
SCLLCDITLWSTYGTVLPTQLPQELDFQYVMKVSSLKKRLPEAAFRKQNYLEQKVCHQDM
CFH

PF12480 // ENSGT00530000063735_1_Domain_2 (424, 520)

LYEVELSNKQGEKIDKLTEYIKTKE--------------LAIIKCLEDRGFFILFTS
AALMSDTDF--ED-ERMGLHGLHLFHSS------LL-TG

ENSGT00530000063735_1_Linker_2_3 (520, 933)

VRDIQVE---DGISLKVIPIL
PALNCALLEAKKSFTEEGIHPNTLVKHNFQEFYRVDKSPSLT-TTSQDGIKETTFFGK--
-LSNGFDLVP-PAEKCPLQSLTQLKAYFSNPSGYILEVSTALDLLAERPQSPC-ISDGIC
DAGFSLVMTPEPEFLDSEAEVRRETETEKNSEETFKGKKGTIVPVRS-ASNLRVQP-KRK
ASMPLLM---------------------Q-SKRVNLCRPFPKRTATGTNNGSDSATTLKL
AKGQFPQKRKR-GAEVLTAQFVQTTKLDRKNQEAP--ISKDVPVETNTKRARKQEKSPVK
TVPRAKPSVKKSPQKQRVNIVKGNQNPRIRKQPRPAKGESASQLQPEISSNGQGDIFSI-
TTAQPENATLA-QKDLPENSIDNCDSQALNML

PF12509 // ENSGT00530000063735_1_Domain_3 (933, 1126)

ADLALSSATSS-TPSSEPRNL----PGS
SELPQN-EVLLS-KENSLLGTSDHEYHRGIKSQKDGLFPKSSSDN-----QKPNSVSDLS
VSQAEESLVPCDQ---------APVKTQSAPTEETLET---S--VASQSSLVAVEHSYAL
LLAEHAKKHL--QQRGLQGPAFAKNGTKGPEAGTPVGKVMPFRHQ

ENSGT00530000063735_1_Linker_3_4 (1126, 1251)

QNTSPLQKPFEDPFI
KRKSRLMASSLKDFCC-SHTVLSCDDSFKVTFKCETEYIFSLDSKYTNNPLEKTVVRALH
GPWNTDLPDNVEEVKLLLHMWVALFYSNQNKVIRSSRKVVEHSNPAKYVS

PF12509 // ENSGT00530000063735_1_Domain_4 (1251, 1582)

INSTLESFEF
SEM-EESPSMERCS----ADPLLETNETSRGETTELSFPDADSLLPFIKLSPARGLELCV
QNEQKEIFVREGH-PDNTESQNLIY-SCNNK---VNGEKAKQESSDKLNTSDVVLLSSIG
STQTNGPFVPGEDKTFQQFDSTRV-----------------TSHNDTVSQTTF-----TK
TYDDVSSQSV--------------------------------------------------
--------------------------------------------------------ICQK
------SAYSTLE-----SKV

ENSGT00530000063735_1_Linker_4_5 (1582, 1609)

DLIQATVHT------KTSALQDLIKHS

PF12480 // ENSGT00530000063735_1_Domain_5 (1609, 1718)

SPIN-KECQSSL
ERK-DEHMGYVMINLEPVTL----------------------TFEKNAYVPVQT------
EVVNRIDKPTTFNMESMK-VSPTTSLRHPVSTFEKAQTE-------DLRDMPSLAVPRQK
GLKFLCASSVSRETLV-KDMCSLQKDTLL-PASSPPNDNSSVMEAVSVV-----KSSSYP
LPSEEVRLSQDFFLQSQGLLSISSEEIIEPSEVEEVISTSVTTTLE--KNYSLNCIPSKS
NISESSLELRKKDKGGPNSENRNFDSFNSAFN-KPTNLSMNREEVNLEL--SEEDSDIDL
TLTISPPTSPKEKMPVDGLDRLEEA-PLSNSEIQGIPEEIV-EPE-------EVTLTENR
GVTSIDYTPVYPAVSET-------------------------------------------
-PLENKERKGDNLQPVTLILSKDSCSLEIAGEVNVTSDFPF-DALIEEVSPAASPDPRAP
AEETQPS-----QAVSPGSLKVHNTECEKSNNFSQIESVDLAITE-------KENSFVLP
PTHSVGQDNLTWEQQMQLSAEMPPVL-NNHPGKKDR-HLSL---PGKVTEEIFQR-----
---------------------------------------EYEK-----VLPFSER-----
---------------------------------QPVS-A---AKYGGDF---KPSLEK--
----LVKSGKPLQPISIENRNLDLEHLALE-A------PQKMIDDESLADTVPSTAAPSG
ILNMPLK-------------------QQTSPKSIKKYLFHSDLQK------NEDNYLQIK
SLHSDSFDGVDLT-QASRHSEIPELGSSSDVA-VLTHYTRPVHVETGFQTQEISVVKMAS
LLKDSEIEAELHEETIAQGGVSPRSNNTSSPKGEQKPVHILQEASTYETEDLL-------
--------SGGFFP----LYAG--SYPDTADTSENN--DKPSASFVPKSF-DSL----VC
GVSEEQREMKSTSEGLGAE--DDSATLDRDM--------NSDIHYEPLSGDSDQD-SFGD
CRN-PELDMEDS-RTLKYSHTRK-EYAAEDGYDSIASF----NNSNNEDWGYST--KVPE
WEASIPPRNWP--IG----IKKEDKCVPYYIQIRDLHGIPRTYANFTITKELKDTTRTL-
HSLRRHPTFTAKCGLISSWTSTWQ-VADDLTQNTLDLEYLRFAHKVKQIVKT-GEAPHSV
SFTSVFPKESPVQIALGAFPLTKMSESSVL-RCAPRSRSPLLVTVVHSQPR---QES-QQ
KRSHMPSNLNS--SSSFWNKMCSQS--RN-LPNSE-RNQTGSFHLNKLKYNS--TLKESR
NDISLILNEYAEFNKVMLNSNQVVFQ-DKELNVS-SGEAT-SPDMYSSFPRRTASYEDMI
TDLCTNLHVKLKSVMKEACKSTFLFYLVETE-DKSFFVRTKNILRKGGHTEIEPQHFCQA
FQREND--TLLVIIRNEDISSQLHQIPCLLKLKHFPSVIFAGADSPEDVLNYTYQELFRA
GGFVVSDDKILETLTLVQLKEIVKILEKLNG--NARWK----------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------

------------------------------------------------------------
------------------------------------------MSKMRNIFHKVATSSSPD
FQTAVSVLHNSYLDSNSKHVFQYSQVTLVKNDIFL

PF12509 // ENSGT00530000063735_1_Domain_0 (156, 316)

HEFETFCRQKKAKRYTEEELKEIYG
FLLFDSEIQAKLVCQQGLRVGSSSITALGDPAKGVYVSKYSDYLHPRPWYHGKSGYI---
---VIFNLVKGKVKVVPENCTPNSTSPTSGYDCHIAASINKVTTKTSHFHAFELSQYYLY
EISGSRVVNRPRQIYPRVIVAFQYSEPRRMSALT-HEDT-N--ELFKVPTSPWKGQLTVE
SKLMCDVTLWSPHGTMIPAWLPQELDIKYVMHVSSLKKKLPEAAFRKSSYVKGRVCHEGI
CFSLYEMEISNKQGTRLDRLKEFIKNKK--------------LAVIKCLEGGRFLLLLTS
SALICDTGK----KEQITLHALLLFPSS-------S-STENELTCEDEEEGISRRVMPIL
PALQYALLVAKKPSVEEGIQLNTAVKHHFHEFTKLERSSSMA---SQDIIDDQLFLSFET
LP-SELELTL-TSEKYPLPSIAHLQSYFSAPDSYTLEVSHALECLSGRSPTPCLISDEIC
DTGFSRFMPLDAELPESRVEGRNETETSKQAEDTDPASEPNLGQSNP-AANLRSHQKKRK
AGGSIETDAEKNWGPLRERN--------Q-NARVNLCCPFPKKLRSKAKDIPSSETTLKL
AKGQFPQKRKR-GAEVLTAQFVQTTKSVLNSQKTP--VWEDVPEEAKNKKLKKQETTVTK
VVTVTKRVVKRPSQKQRGHMLKSKQNPRSRKHPDSAKGETHSQLPTETSSKGRGTAVAT-
QIDT----TDAAPDDLQAKPSGRCDSLALNMLA

PF12509 // ENSGT00530000063735_1_Domain_3 (934, 1126)

DLALSSATSS-AHLSFPRDP----PAP
SDLPQNNESSLS-TENSPQGTSDHEYHSLARSQSGGPASDTTPKA-----SSDDSSSDVA
VSQREKCLGPSSS---------TSADSPTVLPQETHEA---R--GTNTTSFISAEHSYAS
LTAEQFKKHP--PQKGSQVPAFAKNGAKGPEAGTPVGKVMPFRHQQNSP-VQKLLEDTLV
KPKSSPLSPCSKEDFGHSHTVSSCNGSFKITCKWEAEYVFSLDSKYTNNPLEKTIIRALH
GPWDSDMPDNVEEVKLILHMWVALFYSNQNKVLSSSRKVVEHSNPVKYVSINSTMDSFEF
SEISEESLGEEGHP----GSPGLEEDQPSRNSLSKISFPCTNSLLSSSMPASSSGLESCT
LDEWEDPF-SEEDPPGVRECQDDA-VSCSNE---INGKRMEEEPHGRPEDSTSM-LSGEY
CN----PHIQAEDEK-------------------------------------------NE
SYQKPEASNV----A--------------------------------------------F
AKVDISQTLSTKTPQDKMISDQSVASTLKTKKGLLSKV-----------------GACEN
---------SAEERGPRRKVAECQ------------------------------------
-------------------------------------EAEKIPGERSPCTSITK------
NVDSQTDVAPVSGTEFIRKVSSVPS-------RETTQAR----LHEDYRDTSSAYRREPA
DDKHLCNSSEEKGKLG-KENYSPQKRFTV-SISETPTGSTLIEAITSPT-----ALPACQ
ALSDDM-KAKEGFLLIQGLQSVSSSQVQPA------AITTSV----DRETDSARCMF-PI
PSLPIPLEK-EREEGDLRCESMHFESASLAFA-KGACIPMDREEAIEFSESDSEISAIEL
TLTISPPSSPMRARN----------DPLEDLEFQDNSEEPLELPSTNYT----GTSPEDK
EINTNDCISLCLKELLE------PQKSQE---SQYFDLLSDRLGNREEAK----------
----------------------------------MILKSPL-GASTEAESPASS--SKDP
SGETPPL-----QHMVPRILDLHNQGFEEVPESSLMGSAHPPTGASLE------------
------NDT------------------------------TTQEKQAESSTEVTTSSTEVT
TSLNSPQEKKESP-VLP-------PE-------ERDWE---GNSPVGQSNGLGKPNNPEV
ALEELTKPEDSWPPDSKAKKVLGQESLSLKCVISETS-----------------------
---------------------------------EPPYKHNERKRERFLCVPALLSSTLSQ
--------------------------PQDSPRNSEVDFQGSVLGL------REHGQWQGQ
SLNSDGVSQNPFLEAR--PHLESSKCASEGHI-SPTRDTGRGHEEAQFQEGETPAFQKAK
SLQSTTS------PAGDPDEAPPDS--------------ASATTSVAEANGRKTLQSQKR
PEHEKKDGDSGHRPTD-SPSAALGT---PPDREAEMA-EEVSGRGLPTSSVPKALGSSAC
RDHVAHG---CPVR--QPEAEPAANPLGRDGAPNW----NSSFYSTPLSTKAPGQESFGG
AKKQHKLSSEEF-GVLR---TRKRAEAAAANYDSPVNA----DRSDREGWDYAS--KAPG
LEAGAQQGSCIPT------PREKERSVPFLVNIRDQHGISRAYANFTITKKVKDNTRTL-
QVLKKPPSVPAESGLISSWPGTISQSPDSLTQNTLDLEYLRFSYKLKQMMKN-PKSSLPP
S-LHFPPAESPTPSGVETFPLTKEPEAPSLQHPVYRSRSPLKVTIASSESQRGAAG--WS
PRKQHD-DLR-----------SRSDRPSKNLPRSG-RGPSHPAHLRKLRYDG--KLKESW
NGISLILSEFTEFSKVIMNSNQQILQ-ENSVNVAPG-EAAAQKTVLLVCPRRPVSFENLI
TDLCTNLRNKLGSVMREVCKSSFMFYLIETETDGSFFLKAKNFLKKAGHVEIEPLHFCQM
LHRDSSSSPLVVFIRNEDIATHVHQIPCLLKLKRCPGVIFAGVDSPEDVLGSTYQELFCA
GGFVVSDNKVLEAMTLVELKDVIRVMERLNE--NGRWQWLLHYQESKKLREGNRMDSIAH
KKNSILKSCLGTNMIEVLHYHQCDMHSASKSDTLKCLLGLQVQRVAARFAVYLTEKLTA-
-ATESFESSGILVTDVTTFVA---------TLPQAAAPFKSSYW----------------
-----------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------MATPA-H----------KILISPWKGKLTIQ
DCVLCDITLWSNYGTGIPAQLPHKLDFKYVMQVSSLKKKLPEAAFRRQIYLEERVCFQDL
CFNLYEAELSNKQGKEVDKLIDYIKNEEVVRI----------------------FLK---
FGL-------LRQ-NLVGLKLMAIFQPQ------TH-GKVKVLKIE---DDISWKVVPIL
PALNSALLEAKKVLPEEETHPNILVKRNFQELYKVDKSLSLT-A-AQDGKKDTTFFGT--
-LSNSFDLVP-SPEKCAIESVTQLKSYFSDPTGYTLEVATALDLLAEHLPSPY-ISDGIC
DAGFSLVMTPDPEFLDSEAEVKKETETEKNFEEMFKA-----------ASNLRVQP-KRK
AAMLSVV---------------------P-SKRVNLCHPFAKRTP-ATDSRSHSPPTLKL
VKGQFPQKRKR-GAEVLTAQLVQKTKLNRKNQDVP--VSKEVPVATNAKTSRRREKSPVK
TVRGAKSSMKKSSQKKRVNTIKSSKNPRIKKQLHA--EETALQLQSEISSDGQKDGISI-
NTAQPQSTTVT-QKDLPENSIITCDSQALNMLADLALSSAASS-TPLC

PF12509 // ENSGT00530000063735_1_Domain_3 (949, 1130)

EAKNL----PCS
SELPQN-DVSLS-REGSVYGTSDHEYHRGLKNPKGVLFPKSSCD------QKSNSESDLT
VSQE-ENLVPCNK---------TPANAQSILHKETLEP---S--GASQISLIIVEHSYAL
LLGEHSKKHL--LQRGLPGPTFAKNGTKGPDTGTPVGKVMPFRHLQNPS

ENSGT00530000063735_1_Linker_3_4 (1130, 1288)

PLQKFSEDSWV
KRRGRFISSNLKNVFC-SHTVVSCDGSVKVTFKCETGYAFNLDSRYSNNPLEKTVVRALH
GPWDINLPENMEETKLVIHMWVALFHKNQNKVIQSSRKVVEHSNPAKYVSLNSTLECFEL
NEI-EESSSVERCS----VEPLLEPNG

PF12509 // ENSGT00530000063735_1_Domain_4 (1288, 1572)

MSRGRADEVSFHGPNGFLPFIKVPSSRGLELCV
QNEQKEIFATVCH-T---ESQNFIY-SCNNE---VIGEKAKQKSADKLEASNLV-LSVTG
NTQTNGPFISDEDKTFQPLDSKRM-----------------VSYNDTGTQATF-----TR
TYVEANSQSE--------------------------------------------------
--------------------------------------------------------MCGK
------SVYSHLE-----SRADILHT----------NTNVVKDLIQHSSPIH-NQGQSSL
EKT-DDNTDYMMINLVNSYF----------------------HLEKNACVPXXXXXXXXX
XXXXXXXXXX---------------------XXXXXXXX-------XXXXXXXXXSIRTE
NTKYLSASSGKRETLDD-------------------------------------------
-KLEEMKHTQDVCLQTQNLSSISSEGIIEPSQVEV--SPSASASLG--KRNSYDCVPPKN
NISDKSLELRKNSKRNLSCENMNFESFSSVFA-MSINLPMNGQEVSLEL--QEENSDIDL
TLTISPPASPRERVPANETEQLQES-PGANLELQNIAKEIV-EPE-------EVTLIEKR
EVISASSVSAYSTLSKE-------------------------------------------
-PLGNRERKSDSSQPITFILSKPNCTLEIGEEINVTSDFPF-NSLIEDVSPASSLDS---
------------PAVSPGSLKLYAAQCEKTNKFSQIESDDSAVTE-------KENSFVGP
TTHLEGQE--IQLQQIQLSAKMPLIL-TSHPAKKD--RLIF---SGKTTEEIAPS-----
---------------------------------------EHGE-----GFSFSEEVQYY-
DP-ELS---------------------------KAAL-A---ANYGNNF---KPSIEK--
----LVKSGNPLQPVSIENKNLGFKHLVSE-SNELPFSSTKTIENKSLADTV-SKTAVSG
IMNIPLK-------------------EQDSPESIKENVYDSDLKT------DSGSYIQVK
FMNSVPVDETDVT-QIHVQPETPEFCSASDSD-IFTQCARPESIERGFQTQEISVIRMAN
LLGNSRTEAELHEEGTDLGAVNLQSSSGASTKSKQESVQTQSGTSVCEKKEPL-------
--------SGEILP----MDAC--PYNSTVHTNESIS-EESSATFVPESF-DHL----VY
EVSKECIDQKSTNEGQKDE--ADSKILGKSVAVSV----NYDMHHDPFSGDSDED-SLDN
FRN-PRLDMEIS-SILKSSYTGKNEQAVKDDCDSLGSF----HNSDNEACNYSN--EVEG
LETSILPRNWA--TG----LKQADKCVPHCVQIQDLYGIPRIYTNFTVTREFKDMTRTL-
HRVRRDPSFTVNCGLLSSWTSTWQ-VADNLTQNTLDLEYLRFIYRLKQLFRMEGSRQ---
-------SDSPLQISLGDFHLTEMPKPPVL-SPTYRNRSPILVTVLHSDTR---EQS-EY
RSGHAPSDVDS--SSSFWKERCSHN--RN-LADSQ-SNQTISFHLNKLRYNS--TSKEFR
NDVSLILNEYAEFNKVMMNSSHADFQ-DEELDRT-SEEAI-SQEMYPSFPRQTTSYEDII
TDLCASLHTKLNSVLKGTCKSPFFFYLVETE-DKTFFSRTKNILRKGGHTEIEPQHFCQA
FHRMDD--TLVVIIRNEDISSHLHQIPSLLRLKRLPGVIFAGVDNPEDVLSDTHQELFCT
GGFVVSDDKILETITLAQLKEIVKILEKLNR--NGRWKWLLHYRENKKLKENVRMDSVAH
KKNLILRSYQSANIIELLPYHHCDSRSQTKAEVLKCLINLQIQHVDARFAVFLTGKF-T-
-TDEVFGNNGILATDTNHFIE---------NIQQVAAPFRSSYW----------------
-----------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------MAAPT-SKSILEH--NKNALISPWKGQFIIQ
GCLLCDMTLWSTYGTVVPVQLPRELDFKYVMKVSSLKESLPEAAFRRRNYLEQKVCCQDL
CFDLY

PF12480 // ENSGT00530000063735_1_Domain_2 (426, 522)

EVELTNKQGENIAKLMEYVKNKE--------------LALIKCLEDRSFFILLTS
SALTPEPGF--GA-EQMGLHGLHLFRAP------QT-AGAK

ENSGT00530000063735_1_Linker_2_3 (522, 949)

DLKVE---DGISLKVMPLL
PALSYALLEAKKSLSEEGIPPNVLVKHSFQELYKVDKSLSLM-APPQDGVKDTASSGR--
-LPHALDLPP-PLETCPSESLTQLKCYFSDPAGYTLDLSAALDLLAEHPRFPC-ISDGIC
DAGFSLVMTPDPEFLDSEMEIRKETETTEKSGRKLKVKKKAVTP----SSSQRVQP-KRK
ASTSAVT---------------------LPSKRVSLGRPTSKRTVPRTDNRS-CNPTLKL
VKGQFPQKRKR-GAEVLTAQIVQKTRLERKKQEV--SVSKDAPVPTNAKRAKKQEKSLGR
IASQPKPPVKKSPQKRKVNVARGRRSTKVRKQLQPAKKEIALHLQSEISSDGQKDGLNL-
STSQQESIAMI-PKGPLENSVISCDSQALNMLADLALSSAASS-IPSC

PF12509 // ENSGT00530000063735_1_Domain_3 (949, 1130)

KHRNL----PCF
SDVPRN-NVLLT-KENPLHGASDHEYHKGVKSQKAVLLPKPYSD------E-ISSESDLT
RSQE-ENLIPCAQ---------PLAVAQPAPHAEAQEL---S--DASQNS-VVVEHSYAL
LLAEQSHKHV--HQRKLPSPAFVKNGTKGPEAGTPVGKVMPFRHLQNTSPLQKLSEDALT
KRKSLFVSSTLKEFFC-SHTVLKCDGSFKITFKCEGEYVFSLDSKYTSNPLEKTVLRALH
GPWNTDWPENVDDVKLLLHIWVALFYSKKNKVIGSPRKVVEHKNPAKYVCINRSLESLDH
SEI-EEFSNVERPSIGGSVDPLLETKETHIGHATNITFPGPNCLLPFINPPTTRDLELCV
QNDQKEVFTGECH-LDTSGNQNFIY--CNTE---VTGGKAKLELSDKLETSNVV-LPGVV
SAQSNGTCIPSEDKTCQS---TKM-----------------VSYK-SVTQATL-----TT
AYDEAGSELMCQKSVFDNLENKVDS--FHPSLLIKTDESGSESMCQKSVFDNLENKVDSF
HPSLLI-----------------------------------------KTDESGSESMCQK
------SVFDNLE-----NKVDSFHPSLLI------KAGAVQDVIQHSSHIN-NECQPSV
ERR-EDNVECMMVNLDPVTL----------------------AFEKNANVPIHT------
-KVNTTDKPKGFNIELVKQVSPALSIQYPVSAMEEVQTQ-------SSRNVPSLAMSEYK
DSKCLSASSVKKETPP-DSLCLLQKESPL-T--SS--ADGLIMEALSLV-----KSSSYS
LASNKTKCPQDASLQTQNGLSMSLDEVLEPSKVI--VS-STSVTLR--EQQSPSCIPAMS
DVAGASSVIMNSGNSSLNQEK-ILQTFNLVFP-KHTGLSLNREEVSMEF--SGEDADIDL
TLTISPPTRPSEEIAAGEIEQLQRT-PVSNVGQQSRSEEMVEPEE-------QERLIKNR
EMNSASCLSVYPVESRE-------------------------------------------
-LLK-------------------NCTPEITEKFNVTSVFPF-GPLIE-VSPASSPDPIVQ
SGDRQLS---------PCCLKLHSSQSEESNQFSQMKSEEVTMPE-------KAS-LLG-
PESPKGQDKSAEVQ-VQISAEMPQIP--TNAEVEG--RLNV---PGKGTEVSVPS-----
---------------------------------------EQSE-----NLSFLEKVQCD-
-A-ELN---------------------------KLTS-P---AKYGDNF---K-PLEK--
----HVKSGNLLEADCIENRNMDVKHLALE-SSVPSCSPRKVVENKSLTDTLVSIT-TSG
IVNKSLK-------------------Q-TSSKNIKENVCDSDVKT------EADSNMQVE
AVNSAFIDKTDAQ--AHSHPEVSECASSSDSA-QRTYYTQPVRVEPGFQTQGTPVVRMAG
LLKNIG--AELHEERMGLSATGLQSNSMT-TKDEQKTVHVLQDT-ICEVKEFL-------
--------NGDVFS----QNAH--SCQNAVDFSKSIS-EEPSDSFVPEFV-DS-----IC
GVYKEHTLIESPSMVHETK--ADAETLSRDTEISV----NASISCGPCSGDCVQD-SY-D
CEN-CKFDVEN----LRGNRESQ-KHAVKDSSDSFTSL----NNSD-DTRACSS--KIST
IEIHIPPRDQE--TEPRP-ISPN-KCIPRYIQIPDSHGIPKTYTNFTITKEVKDTTRRL-
HSLKKHRNFRANCNLLSSWASTWH-VTDDLTQNTLDLEYLRFDHKLKQIKK--GNSQQ--
---SSFPKESLVQISVGTSPSTQTSETSGL-HLSPKSRSPILVTVVQADTR---QKS-HH
RRSCLPSSLDG--SGSFWKEKCQ-R--RN-LKNSE-RSQTVPFHLNKLKYNS--TLKEPR
NDISLILNEYAEFNKIMMNNNQIVSQ-DEELNAA-SAEAM-FQE--AYQPRQSVSYKDVI
TDLCATLHVKLKGVVREACKSPFWFYLVETE-DKSFFLRTKSILKKGGHTEIELLDFCQA
FHRENE--TLLVIIKNEDIISHLHQIPSLLKLKHFPSVIFAGVDSPEDILNDTYQELFRS
GGFVVSDDVILENLTLAQLKEILKILEKLNE--NGKWKWLLHYRENKNLKEDVRVDSVAH
KKNLILKSYQSVNIIDLLHYHNCDSPSSTKAEILKCLLNLQIQHISARFAVFLTDKPTV-
-STEIFENNGILVTDVNYFTE---------NIQKIAAPFRSSYW----------------
-----------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------MATPT-YKISFFLFSFLKALISPWKGQLIIQ
GCLQCDITLRSTYGTVIPVQLPRELDFKYVMKVSSLKESLPEAAFRRQNYLEQKVCCQDL
CFDLY

PF12480 // ENSGT00530000063735_1_Domain_2 (426, 522)

EVELSNKQGENIDKLTEYIKNKQ--------------LAIIKCLEDRGFFILLTS
SALTPEPDF--GD-EQMGLHGLHLFYSP------QS-TGAK

ENSGT00530000063735_1_Linker_2_3 (522, 951)

DLKVE---DGISLKVIPIL
PALSCALLEAKKSLPEKGIPPNILVKHTFQDLYKVDKSLSLT-TL-NHEMKDTAFIGK--
-LSHAFDLAP-PLEKCPPESLTQMKSYFSDPSGYTLDLSTTLDILAEHPQCPC-VSDGIC
DAGFSLVMTPDPEFLDSEMELRKETETT-KSGKTLRTKKRAVALLTP-VSNLRVQP-KRK
ASTSAIM---------------------LPNKRGSLGRSLSKRTAPKADSGS-CNPTLKL
VKGQFPQKRKR-GAEVLTAQFVQKTRLDRRKRDT--SVSKDAPVATNAKRAKKQEKSPGR
VVSRPKPPLKKSPQKRKVNVTRGRRNPRTRKQLQLAEKDVSLHLQSEISSYVQKDGTNL-
STAQQESIAAI-SKGFPENSIINCDSQALNMLADLALSSAASS-IPSCEL

PF12509 // ENSGT00530000063735_1_Domain_3 (951, 1130)

RNV----PCF
SELPQN-NVLLS-KENSLHSTSDHEYHRGVKSQKGILLPKPSSD------EKIDSKLDVT
FSQE-ENIVPCAQ---------PLAISQPALLEEARES---S--DASQNS-VAVEHSYAL
LLAEQSKKHL--HQRKLPSPAFAKNGTKGPEAGTPIGKVMPFRHLQNTSPLQKLSEDSLT
KRKSLFVSSSVKDIFC-SHTVLSCDGSFKITFKCEGEYTFSLDSKYTSNPLEKTVVRALH
GPWNTDLPENMEDVKLLLHMWVALFYSKKNKIMGSPRKVVEHRNPAKYVCINRSVDSFDQ
SEI-EEFSSVERYS----VDPLLETKEACEGHGTNRTFPGPNCVLPFISPPTTRDLELCV
QNEQKEMFTGECH-LDTSGGQNFTS-SCNNE---VTGGKAKQELPDMSETFNMG-LSGVA
SAQSNGSCIPSEDKTFQS---TEI-----------------GSCNDSVTQATL-----TT
VCDGARIEPM--------------------------------------------------
--------------------------------------------------------MCQK
------SVVGTLE-----NKVDTFHPSLLI------KTGAVRDVIQHSSPIS-NNCTPSV
ERT-DDNVEYMMINLDPVTL----------------------AFEKPAYIPIHK------
-EVNTADKPTDFNTELVKQVSPALSIQHPLSTLEKAQTQ-------CPRDIPSLAISECK
ESKCLSTSSLKKETPP-ESLCPLQKEIPP-PTSSA--DEGLVTEALSFV-----KSSSYS
LASDKTKCPQDSFLQTQNGFHMSLDEILEPSQVKV-SS-STSATLG--NKQSLNCIPTIS
NITDGSSEVRNNDKSSLNQEK-GLQTFNSLIP-KQTNLSMNREEVSMEL--LGKDSDIDL
TLTVSPHTIPREEIASDEIEQLHRA-PISNLGLS-RTEEMVEPEA-------QVSHIKNK
EVSSASLMSVFSVESRE-------------------------------------------
-PLKET--Q-------------KNCAPKVAEEINVPSGFPF-GPLIEEVSPASSPDPIVQ
TEETQPS---------PCCLKLHGTQSEK-NKFSQIKSGDLTIPE-------KGNSFVG-
PKTSMGQDKLPHVQ-VQLSAEMPQIL--NNAGREG--RVTL---PGEITEFSVPD-----
---------------------------------------EHNE-----DLSFSEKVQCY-
DT-ELN---------------------------KPTS-P---PKYGDNF---K-PLEK--
----LVKSGNPLQAVCMENRNLDIKPFALE-SS--------VVENKSLADTLVSVTTVSA
IVNMSIK-------------------Q-TSSKKN-KNVCDSDLKT------EGD--MQAG
SVNSASIDKTDVV-QANMHPEISNFVSSSDHA-QCTYYTKPTSVEPGFQTQEIQTPRMAH
LLQNNG--TELNEERMDLSAIDLHSNFTL-TKGEQKTTRVLQDTSKWEEKKPL-------
--------NDGISS----QNV--HSYQNTADISESIN-EEPSASFVPESV-DS-----AC
GIYKEHIVSENPNMGHKTK--ADSETLSRNTEISV----NDSTCYGPLSEDTNQD-SL-D
CRN-CKLDVENL-CTLRGSHANQ-KDAIKDSNDSFTGL----NISD-NTWEYSR--KISD
LETHTPHRNWD--TEPCP-ISTN-KCMPRYVQIPDSHGIPRTYTNFTITKESRDTTRTL-
HSLKRHWNFTAHCSLLSSWTSTWH-VADDLTQNTLDLEYLRFDHKLKQIIKK-LDSQ---
----HFSKESLTRISVGTCASTQTSDASLL-HHAPKNRSPILVTVVHSDTR---QQS-HR
RRGHSPSNLDS--SSCFWKEKCSQS--RN-LKSSDCSSQTVPVHLNKLKYNS--TLKEGR
NDISLILNEYAEFNKIMMNSNQIVSQ-DKELNIA-SAESV-SQE--TCQPRRSVSYKDVI
TDLCATLHIKLKGVMREACKSPFWFYLVETE-DKSFFLRTKSILKKGGHSEIELLDFCQA
FHGESE--TLLVIIKNEDIISHLHQIPSLLKLKHFPSVIFAGVDSPEDILNDTYQELFRS
GGFVVSDDDILENLTLVQLKEIVTVLEKLNE--NGRWKWLLHYRENKKLKEDVRVDSIAH
KKNLILKSYQSVNIIELLHYHKCDSPSPTKAENLKCLLNLQVQHINARFAVFLTDKPTV-
-STEVFENNGILVTDVNYFTA---------NIQKIAAPFRSSYW----------------
-----------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------MAPPA-HKSILE--CSENVLMSPWKGKLIIQ
DRMLCDIALRSTYGTAIPTQLPQELDFKYVMKVSSLKKRLPEAAFRKQNYLEQKVCFQDL
CFNLY

PF12480 // ENSGT00530000063735_1_Domain_2 (426, 522)

EVELSNRQGENIDKLTECIKNKQ--------------LAIIKCLEDRGFFILLTS
SALLSEPDF--GG-KQMGLHGLHLFHSP------RS-AGVK

ENSGT00530000063735_1_Linker_2_3 (522, 949)

DLKFE---DDISVKVIPIL
PALNCALLETKKSLPEERIHPNTLVKHHFQERYKADRSPSLT-VAPQERMKDPTFLGK--
-LPSGFDLIP-PAEKCPLESLTELHSYFSDPSAYILEVSTALDLLAEHPQSPS-VSDGIC
DAGFSLVMTPDPEFLDSEVEVRKETETRKNSEEVLKAKKRVVVPLSP-SSNLRVQP-KRK
ASMPHVV---------------------R-SKKMNLCRPFPKRTAPRADNSLDSPTTLKL
VKGQFPQKRKR-GAEVLTAQFVQKAKLDRKNQEAP--ISKDVPVPTKAKRARKQEKSPVK
TVPRAKPPVKKSPQKQRVNIVKSNQNPRIRKQPQPVKGETVSKLQSEISRDGQEDGISI-
NNVQPENTTVA-HNDLAENSIVNYDSQALNMLADLALSSATSS-TPVS

PF12509 // ENSGT00530000063735_1_Domain_3 (949, 1125)

EPRNL----HSS
SELPQN-DILLS-KENSLRGTSDHEYHRGVKSQKGGLLPNPSSD------RKSNSGSDLT
VSQNEESLVACSQ---------TPAKAQSALTEETLES---S--DASQSSSVSVEHSYAL
LLTEELKKHL--QEKETPSPPFPKNGTKSPEAVTPVGKVMPFRH

ENSGT00530000063735_1_Linker_3_4 (1125, 1288)

QPGLLLQPKPSDEPVV
KYKDRPKSSGAK-ESC-SHIVFSCDDSVKITFKCETEYAFSLDSKYTNHPLEKTVVRALH
GPWNTDLPDNVEEVKLLLHMWVALFYSNQNKIIRSSRKVVEHSNPAKFVSINSTLESCEL
SEI-EESLDLERCS----ADPLLETNE

PF12509 // ENSGT00530000063735_1_Domain_4 (1288, 1583)

ISRCHAAEVSFHDPNCLLPFIKTPPTRGLELCV
QNKQKKAFARECH-PVIQENQNF-VCSYNNE---VIGEEAKQESSDKLESSNVV-LSGIG
TTQTNGPSVSSEEEISQPLDSTRV-----------------PFYSGTVTQATF-----TR
TDDGTGSQPV--------------------------------------------------
--------------------------------------------------------MCQS
------SAYSSLE-----NQVDVPDAPIQT------KTDALQDCIQHSSPIN-NECQPSL
ERK-DDNMEYVVINLEPVTL----------------------PFEKKAYVPIQT------
EVVNTAEEPTTFNNELIKQVSPAASLRHPVSTLDKTQTQ-------GLRDIPSLVMAGQK
GTKYLCASSVGRETLD-KEMCVLQKEMPL-PV-SLPSDKAMVMEALSLV-----KSSSYP
LPREEVRCTQDFLSQTRSLLGLSSEGLLELTQVEV-DSSSPFTSLG--KLCSLNRVSSGC
YTSGDSLELRKNDKNGPNIEKMNFKAFDSVFM-KQTSLSLNR-EVSLEL--TEEDSDIDL
ALTISPPTSPREEMPAVEIEQLQEH-AFSNLEHQDVAEEIG-KPE-------EVALTESG
EVNSADYESVYPTVSEE-------------------------------------------
-PVEKKDRKGDNLQPVTLILSKENCTLEIAEEINVTSDFPF-DPLIEEVSPASSPDPPVP
VKETRPY-----QAVTPCILKFRGTQCEKSNRVSQCKSEDLGIT---------ENFFVG-
PTHPVGQDNFTQVQQMQVSAEMPLII-TDHPGRKD--RPTL---PGKVTEEIVSS-----
---------------------------------------EHDK-----DLTFSGKVRCC-
GRE-LN---------------------------QPAL-A---AEYRGDF---SPPPEK--
----LIKSGNLLQPISVENRNLDLKHLVLE-SSEPPFCPRNVIENKSLSGTLVSTAAPSV
TVNVSVK-------------------QQTSPKSSQKNLFNSDLKA------DEGIYPQVK
SLKAASVDGAYST-QGCVCSVVSTLSSSSDSD-IITHYVRPINAEPEFQAQEIPAVRVAS
LLNNGETEAELPKETTGLGTDGPQSNTT-SLKGECETIHTLPNVSTCETKELL-------
--------NVGVFS----LCAD--LYQNTADTRENLS-KEPSASFVSESF-ETS----VC
GVSTEHIEIENSEEGIKAE--AGSEIPGRDAEVSV----NSNMQYELLSGDSDLD-LLGD
CRN-PKFNLEDS-YALRGSYTRKKEDVATDGYESSLKI----HNNNQEDWGCSS--RVPG
METSPPPRRWT--TG----IKKEEMCVPRYVQIRDVHGILRTYANFSVTKELKDTTRTS-
HSLRRHPSFTASCGL-SSWTSTWQ-VADDLTQNTLDLEYLRFAHKLKQTIKN-GDSQHSA
SSTNVFPKELPTQSSIGAFPLTKISEAPIL-HPAPRSRSPLLITVVESDPR---PQG-QP
RRGHTASNLDS---SSSWRERC-HN--RD-LTNSQ-RNQTVSFHLNKLKYNS--TLKESR
N-ISLILNEYAEFNKVMMNSNQAVFQ-HKELNDA-SGEAT-VQEMYLPFPGRSASYEDVI
TDLCTSLHVKLRSVMKEACKSTFLFYIVETE-DKSFFLRTKNLLRKGGHTEIEPQHFCQA
FHREND--TLIVIIRNEDISSHLHQIPSLLKLKHLPSVVFAGVDGPGDVLDHTYQELFRA
GGFVVSDDKILEALTLVQLKEIIKILEKLNG--NGRWKWLLHYRESKKLKEDERVDSTAH
KKNIILKSFQSANIIELLHYHHCDSRSTTKAEVLKCLLNLQIQHINARFAVFLTDKPTI-
-PREIFENSGILVTGVNNFIE---------NIQKVAAPFRSSYW----------------
-----------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------MAPPA-HKSILE--RSENVLMSPWKGKLIVQ
DRMLCDITLWSTYGAMIPTQLPQELDFKYVMKVSSLKKRLPEAAFRKQNYLERKVCFQDL
FFNLY

PF12480 // ENSGT00530000063735_1_Domain_2 (426, 522)

EVELSNRQGENIDKLTEYIKNKQ--------------LAIIKCLEDRGFFILLTS
SALLSEPDFKNGG-KQMGLHGLHLFHSP------LS-TGVK

ENSGT00530000063735_1_Linker_2_3 (522, 949)

DLKIE---DDISMKLIPIL
PALNCALLETKKSLPEERIHPNTLVK-HFQELYKADRSPSLT-VAPQDRMKDPTFLGK--
-LPSGFDLIP-PAEKCPSESLTQLNSYFSDPSAYILEVSTALDLLAEHPQSPC-VSDGIC
DAGFSLVMTPDPEFLGSEAEVRKETETKKASEEMLKAKKRVVVPLSP-ASNLRVQP-KRK
ASMPHVV---------------------Q-SKKVKLCHPLPKRTAPRADNSSNSPTTLKL
VKGQFPQKRKR-GAEVLTAQFVQKTKLDRKNQEAP--ISKDVPVPTNAKRARKQEKSPVK
TVPKAKPPVKKSPQKQRVNIVKDNENPRIRKQLQPVKGETASKLQSEISRDGQEDGISI-
NSIQPENTTVA-HNDLPENSIVNYDSQALNMLADLALSSATSS-TPVS

PF12509 // ENSGT00530000063735_1_Domain_3 (949, 1125)

EPRNL----HCS
SELPQN-DVLLS-KENSLRGTSDHEYHRGVKSQKGELLPNPSSD------RKSNSESDLI
VSQDEESLVPCSQ---------AAAKAQSALTEEMLES---S--DASQSSSVSVEHSYAL
LLREHSKKNL--QEREIPSPVFPKNGRKSPEAVTPVGKVMPFRH

ENSGT00530000063735_1_Linker_3_4 (1125, 1287)

QPGLLLQQKPPDEPVV
KPKDRPASSRVKKSSC-SRIVFSCDDSVKITFKCETEYAFSLDSKYTNNPLEKTVVRALH
GPWNTDLPDNVEEVKLLLHMWVALFYSNQNKVMRSSRKVVEHSNPAKYVSINSTLESCEL
SEI-EESLGLERCS----ADPLLDTN

PF12509 // ENSGT00530000063735_1_Domain_4 (1287, 1583)

EISRAHAAEVSFRDANCLLPFIKTPLTQGLELCV
HNEKKKTLARKCH-PDTLENQDFVC--YNN---EVIGEEAKQESLDKLETSNLV-LSGIG
STRTNGTSAPNEEEIVQPLDSTRV-----------------ASYSGTVTQTTF-----TR
TYDGTGSQPV--------------------------------------------------
--------------------------------------------------------VCQS
------SVCSTLE-----NKVDVPNAAMQT------KTGTLQDLVQHGSPVN-NECHPSL
ERK-DDNMECAVINPEPVTL----------------------IFEKHAHVPLQT------
EGVNIADEPTTFNKELIKQVSPAASLRHPVSTSEKAQTQ-------GLRDTPPLAVAGQK
GSKYLYASSVGRETLD-KEVCSLQKEMHL-PA-SLPSDKAMVMEALSLV-----KSSSYL
LPSEEVRCTQNFLSQTQSLLSLSSEGLVEPTQVEV-DSSSASTALG--KQCSLNCISSGC
HTSGDSLELRKSDKNGPNTENMNFEEFDSVFI-KQRRLSVSR-EVSLEL--SEEDSNIDL
ALTISPPTSPREEMSAGEIEQFEEA-PFSNLELQDVAEEIG-EPE-------DVALTDSR
EVNSADNVSVYPTVSEE-------------------------------------------
-PVENKERKGDNLQPVTVILSKENCTLEIAEEINVTSDFPF-DSVIEEVSPASSPEPPVP
VKETRPY-----QAVTPCILKLHGTQCETSNRISQRVSEDLGITE-------KEKFFVG-
PTHPVGQDNFTQVQQMQVSAEMPLIL-TDHPGRTG--RPTF---PGKVTEEIVSS-----
---------------------------------------VRDE-----GLSFSGKVQCY-
GRE-LN---------------------------QPAS-A---AEYTGDF---SPSPEK--
----LVKSGNPLQPVRVENRNLDLKHLVLE-SSEPPFSPRNVTENMSLSDTLVSTAAPSG
V----VE-------------------QQTSPKSSQNNLFASDLKT------DEGIYLQVK
SLTTASVDGAYST-QGYMCSVVPTLCSSSDSA-TLTHYVRPINAEPAFQAQEIPAVRMAS
LLKKDETEAELHKEITGLGPAGPQSNTKSSLKGERKAFHTLQDVSACETKELL-------
--------NVEVSS----LCAS--PYQNTADTRENLS-KEPLASFVSESF-DTS----VC
GVSTEHIEIENSGEGLRAQ--AGSETLGRDAEVSG----NSDMHCELLSGDSDLD-LIGD
CRN-PKCDLEDS-CTLRGSYSRKKEDVLTDGCESSLNF----HNHHQGDWGCSS--QVPG
METSLPPGHWT--TR----VKKEEKCVPPYVQIRDLHGILRTYANFSVTKELKDTMRTS-
HSLRRHPSFTANCDLPSPWTSTWQ-VA-DLTQNTLDLEYLRFAHKLKQTIKN-GDSQHSA
SSANVFPKELPTQISTGAFPLTKISEAPIL-QPAPRSRSPLLVTVVESDPR---PQG-QP
RRGYTASNLDN---SSSWRERYSHN--RD-LTNSQ-RDQTVSFHLNKLKYNS--TLKESR
NDISLILSEYAEFNKVMKNSNQVVFQ-DKELNDA-SGEAT-AQVMYLPSPRRSISFEDII
IDLCTNLHIKLRSVVREACKRTFLFYLVETE-DKPFFVRTKNLLRKGGHTEIEPQHFCQA
FHREDD--TLIIIIRNEDISSHLHQIPSLLKLKHFPSVIFAGVDSPGDVLDHTYQELFRA
GGFVITDDKILEAVTLVQLKEIIKILEKLNG--NGKWKWLLHYRENKKLKDDERVDSTAH
KKNMMLKSFQSANIIELLHYHQCDSRSSTKAEILKCLLNLQIQHIEARFAVFLTDKPTI-
-PREVFENSGILVTDVNNFIE---------SIEKVAAPFRSSYW----------------
-----------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------MAAPA-YEI-SLLPLFLKAPIPPWKGKLIVQ
GCVLCDITLQSTYST-VPAQLPRELHFKYIMKVSSLKEKLPEAAFRKQNYLEQKVCCQDL
CFDLY

PF12480 // ENSGT00530000063735_1_Domain_2 (426, 522)

EVELSNKQGENLDKLTEYIKNKQ--------------LAIVKCLEDRGVFILLTS
SALIPAPDF--EE-QQMGLYGLHLFHSP------LS-TGVK

ENSGT00530000063735_1_Linker_2_3 (522, 958)

DWNVE---DDMSLKVVPII
PALNCALLEAKKSLPEERTHPKTLVQSNLQALSRADNSLSLT-AVPHDGVKETVSVGK--
-LPVDFDLIP-PPEKCSVESFIQLKSYISDPSGYSFDVSTAQDLLVEQQQPPC-ISDGIC
DAGFSLVMTPDPEFLDLEEEVQKETETENSENILNTKNNGVMVSVNPLASNLRVQP-KRK
ASVPLGV---------------------H-NKRMNLCYPFPKRATSETDHGSHSPTTLKL
VKGQFPQKRKR-GAEVLTAQFVQKTKLDEKTQEGSI-ICKDIPVATKVKRAKKQEKSPVK
T----KPHVKKSPQKQRVNIVKGKRNSTIRKQPQPAKRETTLQLQSEISSDGQKDGISI-
NTAQPECTSNA-PKDLPQNSSIICDSQALNMLADLALSSAASS-VPLCDPRNL----

PF12509 // ENSGT00530000063735_1_Domain_3 (958, 1130)

SS-
TELLQN-DVLLS-KENLLCCTSDHEYHRGVKSQKGVLLPKPSSD------RKDNSESDIT
VNQE-ENLVAGSQ---------APAKAQSALPEEALPSSA-T--SQNLNAFVAVEHSYAL
LLPEHSKKHL--YQRGLPGPTFTKNGTKGPETGTPVGKVIPFRHLQNTS

ENSGT00530000063735_1_Linker_3_4 (1130, 1290)

PLQKFSEDSLI
KRKSRFVTSNLKEFCS--HTVLNCDGSLKITFICETEYKFSLDSKYTNNPMEKTILRALH
GPWNSNVPENVEDVKLLLHMWVALFYSSQNKIIPSSRKVVEHSNPAKYVSINSTLESFEL
SEM-EETSNVEKYS----LDPLLENKETP

PF12509 // ENSGT00530000063735_1_Domain_4 (1290, 1580)

RSHA-KVSFPTSNNVLPFIKSPPMRHLGFCV
QNEEKEAFAREPH-LGTSVSHNSV-CSCNNE---LTGEKA-EELSDKLETSNLV-LSGTI
SKQTNGPSISGEDKTFQSLENTGL-----------------ASYNDTIIQATL-----TT
TSDGSSSQAV--------------------------------------------------
--------------------------------------------------------TCQK
------SLYSILK-----SKGDPFPTTVQT------DTCAIPDLTQHSNLIS-SECQPSL
QKVNDKNMECVMINVEPLTL----------------------TFEKNTYEQIHT------
-DVNITNKSPTFNTELIKQISPTVSVKHPIISLEKAQTQ-------GLQEIPSLAPTRQE
DTKYHSVSSVSEEMIA-EELSFIQKEIAP-PISSPPTEKPM----LSLV-----ESSGYP
VANEDINHSEDVFVKTPSLFSISSEEIIEPSQVEV-ASPSASAALG--N-DSLNCIPPKS
TMLDGSLELRNDDKGSLNHENMNLESLNSVYD-QQSSVFMNKEEVSAEL--SEEESDIDL
TLTISPPTSPREEIPAGRVEELQEL-QLEG-----RAKQIVRSNK-------EATLLENR
EVNSARDISVHPAMSEE-------------------------------------------
-PLQN-------------------CALEIVEEINVNSNNPF-DSLIEEVSPASSPGFPVS
SEEIRPS-----QTVSPCSVKVCGTQYEKSKKCSQIEVEDLPITE-------KENCSVY-
STYPVGKGDLTQVQQIQLSAEVPLKL-TDHPGTKG--RVIL---PGKASEGIVIS-----
---------------------------------------DHDE-----VLAFSEKVQCC-
DA-ELN---------------------------KPAS-V---AKYEGDF---KPYLEK--
----LAKSGNPLQPINT----------------------------------LVSTTHLSG
IMNTPFK-------------------Q-TSPKSIKNTR-DC-------------------
DLKIDATDGADVT-QAYMHPEFLNLNFSSVGT------TRLPSVNSGYPTQEISVVRMAH
LL-NTETEADLYDKNTDLSTTGPHSHPYT---KDEQKTQVLQSASTCEVKELW-------
--------NGEGFP----VCAA--SDQDTANTSESID-KDSSDSLVSESF-DPL----VC
RVSEEQIVSKSTNERHRVY--TESKTLVRDTEMNM----DINMCYEPLSGDFDED-TL-N
FRN-PKLSLENS-CTLKGSHDSKKEDAAKSSYDSCMNL----NNRDNEAWGYSNNKKVPK
LEINIPPKNWA--MG----LKK-DKYMPAYVQIPDFQGILRTYTNFTVTREVKDERKTN-
LKSHPGSTTNTNVNLLSSW--TWQ-VAEDLTQNTLDMEYLRFAHEVKKVAKNK-------
-PNSIFWKEL--SAQVGAFPSTKVSEASIL-YPE--SKSPILVTIVHSSSS--RQQT-PQ
RRNCSPSNLHN---SSFWKEKCHSG--S--LITSQ-RNQTVPFHLNKLRYRS--TLKDSR
NDISLILNEYAEFDKVMMHSNQVVFQ-DGDFNVT-SGEAT-SQQLYPSFPRLSVSYKNMI
TDFCDNLHVKLKSVMQEASEGPFQFYLVETE-DKSFFLRTKNFLRKGGHMEIEPQHFCKV
FGREND--MLIVIIRNEDIASHLHQIPSLLKMKHFPSIMFAGIDSPEDVLNDSYQELFGT
GGFVVSDDKILEALTLAQLKEMIKILQTLNGNGNGRWKWLLHYRENKKLKESARVDPIAY
RKNLILKSYQSANIIELLHYHQCDSQSSTEAESLKCLINLQIQHINARFAVFLIDKPTFT
ASTEIFENSGILVTDINHFIE---------NIKDVAAPFRSSYW----------------
-----------------------------------------

MGVRAILALSSGDLSKVNTVELCIMRTRCLVNIYLYSRYARKRTIHCVIQFFLFRFSIYD
INREQDYGKHSGGILGDSELRPPSHLPSLLEKTETGLIPAKSGYQTKCFFETVSLCSDSL
FQRAVSILRTSYLDSASEHGFQYSQVTLVKNDIFLNEYKTFYQ

PF12509 // ENSGT00530000063735_1_Domain_0 (164, 316)

EKKASDYTQEELEETCG
FLLFETENQAKLVCQRGLCVGSSALTTLGDPGKGVYISKYSDYLQARPWYHGKSGYV---
---VIFNLIKGRVRFVSENYTSNYTSPSSGYDCHVAVNTHKVSHRTSHFRTFELSQYYLY
ELSGSTVAERPRQIC

ENSGT00530000063735_1_Linker_0_2 (316, 426)

PYVIVAFQYRDPKTMAAPP-HIPKSLLELKENVFISPWKGKLIIQ
GYLLCDITLWSSYGTGVPTQIPHELDFRYVMKVSSLKKTLPEAAFRKQNYLEHKVCCQDM
CFSMY

PF12480 // ENSGT00530000063735_1_Domain_2 (426, 522)

EVELSNKQGGGVDKLTEYIKREQ--------------LAIIKCLEDREFFILLTS
SALIAETNL--GE-EQAGLRGLHLCHSS------AP-AGLK

ENSGT00530000063735_1_Linker_2_3 (522, 949)

DLKVE---DDFSLKVIPIL
PALHCALLEAKKSFTEKDICLNKLVKHNFQELYKVDKSPALT-AASQDGIKETAFFGK--
-VSSDFDLVP-PAEKCPLEAWSQLKSYFSDPSGYILEVSTALDLLAERPQSPC-ISDGIC
DAGFSLAMTPDPEFHDSETEVKKETETEKNSEEVFKARQGAVVPLSP-ASNLRVQP-KRK
ASTLPTV---------------------Q-SKRVSLCRPFPKRTPAGASKGPGSPTTLQL
VKGQFPQKRKR-GAEVLAAQFVQTAKSDRKNQDAP--ISEDVPVAANAKRARRREKSPVT
AAPRAEPPVRRSPQKQRASLVQGEEHPRISGQPPAAKEETASQLQSEIS-EGQKDVISI-
NTAQPETLSVA-QKEPPEDCIVTCDSRALNMLADLALSAATST-APSS

PF12509 // ENSGT00530000063735_1_Domain_3 (949, 1130)

EPRNF----PCS
SELPLR-AALLS-QEPALRSTSDHEYHRGVKSQKGGPFSTPSSD-------KSDAAADPR
LGPEEESAVAGSQ---------APAEAPAALPEEALEG---S--DSSQSSFVAVEHSYAL
LLAEHSRRHL--QQRGALGPAFAKSGTKGPEAGTPVGKVMPFRHQHSTS

ENSGT00530000063735_1_Linker_3_4 (1130, 1289)

PLQKLPQDPAL
RRRARLLPSGLKDFPC-SHTVFSCDGSFKVTFRCEADYVFSLDSKYTNNPLEKTVLRALH
GPWNTDLPDNVEEVKLLLHMWVALFYSSQNQVMRSSRKVVEHSNPAKYVSINSTLDPIAF
SEL-QEASGAEGC-----LDPLSETVDA

PF12509 // ENSGT00530000063735_1_Domain_4 (1289, 1571)

PRGLPAPPSFPDTDSLLPFAKPPPRRGLELWV
QSEQRDLFAAEGH-AEAPEGQNLIY-SCDTE---ITGEKAEPESSDKLEKSNLV-LSRIG
STQTNGPSIPGEDKSFEPLDGARV------------------AYSDALTQTTL-----PR
TYDGISSPSM--------------------------------------------------
--------------------------------------------------------ICQK
------SVYSALE-----SRVDLFHAKRQT------KTGALQGLIQHSHPLN-KECQPSL
ERK--DDVGYVMINLEPVSL----------------------TFEKNTYVPIET------
EAVNRADTPAAL----SKQVSPAPDLSHAVPTFAE--AQ-------GLGDIPSPAVTGQK
GATYLHASPASRETLV-KEMRSLQKDRPV-AGSPSPPDRPVVTEALSSL-----RSSH-S
SPREEMKLSRDFVLQTQSPFSISSEAVVELAQAAETGPSSASAPRD--TGDSLSRVPSRR
A-PGGSAEL-KSSRTGLKSEKVSCGSFNSEFS-KQSGLSLNR-EASLEF--SEEGSDLDL
TLTISPPASPRDEEPEAETEQRLEA-LGPHLELREKAF----SPQ-------GGPRVADR
DVNPAGTVSV------R-------------------------------------------
-APANEDRSSDTSQTATFVLSKETCALEVAEEMHVALDFPF-GSLIEEVSPASSPDPQAP
GTDAQTA-----RAVSSCGAELSEARRESGDPPSQMESVDMAVTE-------KDNSLAG-
PAPPVGQDNLPRAPPVPFPAETPLVF-RRPPERRGT-CSAL---PGAVPEQAVPG-----
---------------------------------------ERDQ-----GPPLSARAPSW-
DA-EPK---------------------------QPAS-A---ARYRD-------APGN--
----QATSGSPLQPAAVEDRSPHVSHLIWD-SRDPPLSPRHILETQPLAAAFVSAAAPAD
-ASLSLG-------------------EQAGPERPPEHLLGGDLKT------DGRCYILVR
SLRSGSVDSAAGP-GGLVHAERPAAGL----------CSGPGAAGPGPQTQEISAVRMAR
LLQNNGPEAGTLGDSVDLGGAGPQWRPPSP-----PAFHRLRAGSAGPSRDLV-------
--------GHGPLP----PCSRADAPPDTAAAGLGGG-QAPSASFVPGSR-APL----GG
GVSGAE----SAGEGPRAP--RDPAPPG----LR----ANPDIHYEPLSGDSDQD-SLGE
CAK-PREDARDS-CAPRCRRAEDK-GASDESDDPFLGL---SHSDDDEDWGRSR--RLPG
LEP--------------------ARRVPAFVRVRDLRGVARAYANFPVTRARSR------
-----APGGVAQGASLRLRTDTGP-GAADLTRSTLDLEYLRFAHKLKQMVKR-GDARRSG
PSAPAFPKAA-----------------PAP-APASRSRSPLVVTVVHSDPR---PPG-RR
ARGHTPHRMAQ--ASSSWKERGAHG--RSPLPNSG-GSQAAALHLHKLKYNS--PWKDSR
GDISLILSEFAEFNKVLLGSGSQAAPRDPEPS-----EAA-APAPGPPCPR-PASYEDLV
ADLCASLRVKLERVVKEACARTFLFHLVETA-DESFFLRTKNLLRKGGHAEMEPQRFCQA
FPREND--TLLVIIRNEDIASHLHQIPALLRLKRLPGVLFAGVDSPEDVLHHTYQELFRA
GGFVVSDGRILDSVSLVQLKEIVRILEKLNA--SGRWKWLLHYREIKKLKEDVRVDSTAC
KKNLILKSYQSANILELLHYHECDSRPSTKAEHLQCLLTLQIQRVHARFAVFLTEKPAL-
-SREVFEDSGILVTDVNDFIE---------NMQKVAAPFRSSYW----------------
-----------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------MAAPA-YKSILE--FSENVLSSPWKGKLTIQ
GHILCDMTLWSTYGTMLPTQLPQELDFKYIIKVSSLKKRLPEAAFRKQNYLEQKVYCQDL
CS

PF12480 // ENSGT00530000063735_1_Domain_2 (423, 524)

NLYEVELSNRQGEKIDKLIEYIKKNQ--------------LAIIKCLEDRGVFILLTS
SALTSESDV--EA-EQMGLHGLHLFRFP------LT-AGEKDAKAE---DDISMKVIPVL
HTLNYALLEAKKSLPKEGARPNALVKYHFQEQCKVDRGPSLT-A-PQGGIKEMAFPGT--
-LSSDFDWVS-PAEKCPSESLTQLKSYFSDPSSYILEVSTALDLLTEPPQSPC-VSDGIC
DAGFSLVMTPDPEFLDSEVEVRKETETKKKS-EVLKAKKGVVVPPSP-ARSLRVQP-KRK
ASTPVAG---------------------P-RRKVNLCRPCPKRAAPSADSGLDSPTTLKL
VKGHFPQKRKREGAEVLTAQFVQKTKLDRKNQDAP--ISKDVPVATNTKRAKKREKSPVK
TVPRPKPPVKKCPQKQRVTIGKGNQNPRVRKQPQPAKGETALQPQSEISSACQEDGISI-
NTIQPQSSTVA-HKDLPENSIVNYASQALNMLADLALSSATSS-TPASEPGNL----LCA
SELSQD-DLLFV-KENSSQGTSDHEYYKEVKNPKGGVSPKPSPG--------NNSGPDFT
VSQDEENLGPCGQ---------ALTKAQSALTEGTLEP---S--YANQSFFICVEHSYAL
FLAQHSRKHR--HQRGVAGIAFTRNRTKGSEGRTPVGKVLPFRHQQTTSPLQKPPVDILV
HKRGRPLSSSLKGFLC-SHTVFSCDGSYKITFKCETEYAFSLDSKYTNNPLEKTVQRALH
GPWNTSLPDSVEEVKLLLHMWVALFYSSQNKVIRSSRKVVEHSNPAKYVSINSMLESSEL
SEV-EDVPSMERGF----TDPLSETNEASQGPAPEVSFPDPCCLLPLIKPASPKGLELSV
QNEQKEIFTGEYH-PDSSEGQSFL-CSYNNE---VIGTKAKQESSDKLETSNLV-LSGIR
NIKTNGPSIPSEDKTLQPLDSTRV-----------------ASYSGTVTQATF-----TT
TYNGISSQPA--------------------------------------------------
--------------------------------------------------------M---
------PHYRTLE-----NKDDIFHVTTQT------KSGALQDLIQHSSPSPIHECQPSL
EGK-DDDRGYVMVSVEPVTF----------------------ALDKNAYAAVQT------
EVTNRADKSTAFNKELVH-LPPATSLRHPMSTLGTAETQ-------SLGDVSALAVSGQK
GTKYLCVSSLSRETPD-KEVCTLQKEMPF-SG-LSPSDSAVAVQAPSLV-----KGSRCL
SPNEEMKHSQDFFLQTQNLCGVSSEEIVEPRLVEV-NSSSASPTLE--EQHSLNCVALSS
RASDGPLELRKNARSDLNSENQNSELFNSVSA-KHSSLSENR-EVRLEL--SEEDSDIDL
TLTISPPTSPREETSARETEQPQES-PSSSLALQDRAEETV-APE-------ELVLPENR
DVRS-GYVSVYPTASEE-------------------------------------------
-PVENKERKGDQSQPVTVILSKENCTLEIAEEINVTSDFPF-DSLIEEVSPASSPDAPVS
LEETRPY-----QAVSPCGLKHHGTQNAKSNGFSQLESRDLGITE-------KENSFVG-
PTYPVGQNDLTQVQHMQSFAKVPLMM-TDYTETK-G-RLAL---PNKVTQEVGQG-----
---------------------------------------KCDE-----SLSVSEMVHSF-
GT-ELT---------------------------QPAL-A---AEYRGNF---KLPLQK--
----LVKSGNLFQPVSIENRNLDLKHLVLK-SSELPFSPRKVMENKSLADTLISSAAPSG
MLDASLK-------------------QQTSPPNIGKTLLSSGVAT------GTGSCVQTK
SLSPAPVAGTQAT-QAYALPEVPAQGSSLECT--VMASLCPVTVDPGFQTQELSVVKMAC
LLENNETEVALHEENMDLGTVGPPPNSVS-PESKQKTIHLLQDMSQCVTEELL-------
--------PSRVFP----MYVG--TCENTANVSENSN-REPYASCIPEPF-DPP----AC
GISKEHVECERAGEGLRLG--AGV----------------GAVHCEPLSIESDLA-PLSV
CGN-PKLDMEDS-CTLRESHTRRGEDAAKDSYGSLTNL----DNSDHIDWSCLD--QVPG
KETNSPSRPWA--ST----LKKEGKCVPCYIQIQDYRGIPRTYANFTITKEFKDTTRTL-
HSLRRHPDFTADCDLLSSWTSTWQ-VTSDLTQNTLDLEYLRFAHKVKQTVKK-RGAQHPA
TSSSIFLKGSPPQAAVSTFPLTKTCEAPVG-HPAFRSKSSLLVTVVHSDSR----QG-QH
RGGPLPSSLHS--LPSFWKKKCDHS--SN-LTNSQ-KNPTASFHLNKLKYNS--TLKDSR
NDISLILNEYAEFNKVMMNSSQVVSQ-DSRLNVD-SGEAAMSPEIYLSCSRQSASYEDMI
TDLCTSLHVKLKNVMKEACNSTFLFHLIETE-DKLFFVRTKNLLRKGGHTEIEPQHFCQA
FHSEDD--TLIIIIRNEDIASHLHQIPCLLKLKHFPGVIFAGVDSPGDVLDHTYQQLFQA
GGFVVSDDKILETLTLVQLKEILKILEKLNG--SGRWKWLLHYRENKKLKEDVRVDSVAH
KKSVLLKSYQSANVVGLLHYHQCDSRSSAKADVLECLINLQIQQTDARFAVFLTEKPTI-
-SREVFENNGILVTDVNNFIE---------NIPKVAAPFRSSYW----------------
-----------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------MAPPA-HKSILE--RSENVLMSPWKGKLIVQ
DRMLCDIALWSTYGAMIPTQLPQELDFKYVMQVSSLKKRLPEAAFRKQNYLEEKVCFQDL
CFNLY

PF12480 // ENSGT00530000063735_1_Domain_2 (426, 522)

EVELSNRQGENIDKLTECIKNKQ--------------LAIIKCLEDRGFFILLTS
SALLSEPDF--GS-KQMGLHGLHLFHSP------LS-TGVK

ENSGT00530000063735_1_Linker_2_3 (522, 949)

DLKVE---DDISMKVIPIL
PTLNCALLETKKSLPEERIHPNTLVKRHFQELYKADRSPSLS-VAPQDRMKDPTFLGK--
-LPSGFDLIP-PAEKCPSESLTQLNSYFSDPSAYILEVSSALDLLAEHPQSPC-VSDGIC
DAGFSLVMTPDPEFLVSEAEVRKETETKKDSEEMLKAKKR-VFPLSP-ASNLRVQP-KRK
ASMPHTV---------------------Q-SKKVNLCRPFPKRTASRADNSSDSPTTLKL
VKGQFPQKRKR-GAEVLTAQFVQKTKLDRKNQEAP--ISKDVPVPTNAKRARKQEKSPVK
TVPRAKPPVKKCPQKQRVNIVKGNENPRNRKQLQPVKGETASKLQSEISRDGQEDGISI-
NSVQPENTTAA-HNDLPENSIVNYDSQALNMLADLALSSATSS-TPVS

PF12509 // ENSGT00530000063735_1_Domain_3 (949, 1122)

EARNL----HCS
SELPQN-DVLLS-KENSLRGTSDHEYHRGVKSQKGELLPNPSSD------RKSNSGSDLT
VSQDEESLVPCSQ---------APAKAQSALTEEMLES---S--DASQSSSVSVEHSYAL
LLTEHSKKHL--QEREILSPLFPRNGTKSPEAATPVGKVMP

ENSGT00530000063735_1_Linker_3_4 (1122, 1287)

FWHQPGLLLQQKPPDDPVV
KPKDRPTSARVKKSSC-SRIVFSCDDSVKITFKCETEYAFSLDSKYTNNPLEKTVVRALH
GPWNTDLPDNVEEVKLLLHMWVALFYSNQNKVIRSSRKVVEHSNPAKYVSINSTLESCEL
REI-EESLGLEKCS----ADPLLETN

PF12509 // ENSGT00530000063735_1_Domain_4 (1287, 1583)

EISRAHAAEVSFRDPNYLLPFIKTPLTQGLELCV
QNEQKKAFARECD-PDTQEDQNF-ICSYNNE---VIGEEAKQE---SLETSNLV-LSGIG
STQTNGPSVPSEEEIVQPLDSTRV-----------------ASYSGTVTQATF-----TR
TYDGPGSQPV--------------------------------------------------
--------------------------------------------------------ICQS
------SVYGTLE-----NKVDVLDAAMQT------KTGTLQDLIQHGSRIN-NECHPSL
ERK-DDNMGCAVINPEPVTL----------------------TFEKNAHVPIQT------
EGVNTADEPTTFNKELIKQVSPAASLRHPVSTSENAQTQ-------GLRDIPSLVVAGQK
GTKYLCASSVGRETLD-KEMCSLQKEMPL-PV-SLPSDKTMVMEALSLV-----KSSSYL
LPSEEVRCTQDFLSQTQSLLSLSSEGLLELTQVEV-DSSSASTTLG--KQCSLNCISSGC
HTSGDSLELRKNHKNGPNTENMNLEAFDSVFI-KQTSLSVSR-EVSLEL--SEEDSDIDL
ALTISPPTSPREEMPAGEIEQFEEA-PFSNLELQDVAEEIG-EPE-------EVALTESR
EVNSADNVSVYPSVSEE-------------------------------------------
-PVENKERKGDNLQPVTLILSKENCTLEIAEEINVTSDFPF-DSVIEEVSPASSPEPPVP
VKETRPY-----QAVTPCILKLHGTQCEKSNQISQCESEDLGITE-------KENVFVG-
PTHPVGQDNFTQVQQMQVSAEMPLIL-TDHPGRTG--RPTL---PGKVTEEIVSS-----
---------------------------------------EHDE-----GLSFSGKVQCY-
GRE-LN---------------------------QPAS-A---AKCTGDF---SPSPEK--
----LVKSGNPLQPVSIENRNLDLKHLVLE-SSEPPFGPRNVIENKSLSDTLVSTTAPSG
IVNVSVK-------------------QQTSPKSSQNHLFPGDLKT------DEGIYLQVK
SLTAASVDGAYST-QGCMCSVVPTLCSSSDNA-TLTHYVRRISAEPAFQAQEIPAGRRAS
LLKNGEPEAELHKETTGPGTAGPQSNTTSSLKGERKAIHTLQDVSTCETKELL-------
--------NVGVSS----LCAG--PYQNTADTKENLS-KEPLASFVSESF-DTS----VC
GIATEHVEIENSGEGLRAE--AGSETLGRDGEVSV----NSDMHYEL-SGDSDLD-LLGD
CRN-PKFDLEDS-YTLRGSYTRK-KDVPTDGYESSLNF----HNNNQEDWGCSS--WVPG
METSLPPGHWT--AA----VKKEEKCVPPYVQIRDLHGILRTYANFSITKELKDTMRTS-
HSLRRHPSVTANCGLPSSWTSTWQ-VADDLTQNTLDLEYLRFAHKLKQTIKN-GDSQHSA
SSANVFPKESPTQISIGAFPSTKISEAPFL-HPAPRSRSPLLVTVVESDPR---PQG-QP
RRGYTASSLDS---SSSWRERCSHN--RD-LRNSQ-RNHTVSFHLNKLKYNS--TVKESR
NDISLILNEYAEFNKVMKNSNQFIFQ-DKELNDV-SGEAT-AQEMYLPFPGRSASYEDII
IDVCTNLHVKLGSVVKEACKSTFLFYLVETE-DKSFFLRTKNLLRKGGHTEIEPQHFCQA
FHREND--TLIIIIRNEDISSHLHQIPCLLKLKHFPSVIFAGVDSPGDVLDHTYQELFRA
GGFVISDDKILEAVTLVQLKEIIKILEKLNG--NGRWKWLLHYRENKKLKEDERVDSTAH
KKNIMLKSFQSANIIELLHYHQCDSRSSTKAEILKCLLNLQIQHIDARFAVLLTDKPTI-
-PREVFENSGILVTDVNNFIE---------NIEKIAAPFRSSYW----------------
-----------------------------------------

-------------------------------------------------------MSIYD
INREQDYVTNSGGILGENELRPPSQLHCLLEKTEPGFIS-------EKIFETVSLSSDSL
FQRAVSILHTSYLDSASEHGFQYSQVTLVKNDIFLN

PF12509 // ENSGT00530000063735_1_Domain_0 (157, 316)

EYKTFYQEKKASNYTQEELQETFG
FLLFETENQAKLVCQRGLCVGSSAITTLGDPAKGVYISKYSDYLHARPWYHGKSGYV---
---VIFNLIKGKVKFVSENYTTNYTSPSSGYDCHVAANTNKVSHKTSHFRAFELSQYYLY
ELAGSTVTERPRQIC

ENSGT00530000063735_1_Linker_0_2 (316, 424)

PYVIVAFQYREPKRMAASA-PRSVFE--LRENAITSLWQGKLIIQ
GCLLCDITLWSSHG-TVPTQLPHELDFKYVMKVSSLKKRLPEAAFRKQNYLEQKVCCQDI
CFR

PF12480 // ENSGT00530000063735_1_Domain_2 (424, 525)

LYEVELSNKQGEKINKLTEYIKNEQ--------------LAIIKCLEDRGFFILFTS
SALISGTNF--EA-EQTGLHGLHLFHPS------LL-AGLKESK

ENSGT00530000063735_1_Linker_2_3 (525, 933)

V----DNISSKVTPIL
PALNCALLEAKKSFTEEGVCPNMLVKHNLQELFKVDKGPSLT-AASQNGIQETAFLGQ--
-LSNGFDLVP-PAEKCPSQSLTQLKSYFSDPSGYVLEVSAALDFLAECPQSPC-VSDGIC
DAGFSLVMTPDPEFLDSEVEVRKETETKKNPEEMVKVSQGAVVLLSP-ASNLRVQP-KRK
SSVPPAV---------------------Q-SKRVNLCCPFPKRTPGGASKGSDSPTTPKL
VKGPFPQKRKR-GADVLAAQFVQTTKLDRKNREAP--ISKDAPVATNAKRARKQEKSPVK
TVPRAKPPMKKSPQKQRVNLVKGKQNLRIRKQPQPAKGETGSQLPSEISSVGQEDVTSI-
NATQTEGISVA-QKDLPENSIVNCDSQALNML

PF12509 // ENSGT00530000063735_1_Domain_3 (933, 1125)

ADLALSAATST-TPSSEPRNF----PCS
SESPQN-DVLLS-KEHSVRGTSDHEYHRGVKNQKGGLLTKPSSE------KKSNPTLDST
ISQMEETWVPGDP---------PPMEAPSALPEETLET---S--DASQSSFVAVEHSYAL
LLAEHSKKHL--QQRGITGPAFAKNGTKGPEAGTPVGKVMPFRH

ENSGT00530000063735_1_Linker_3_4 (1125, 1251)

QHSTSPLQKLSEDPGC
RRKGSLLSSSLKDSYC-SHTVYSCDGSFKVTFKCDSEYAFSLDSKYTNNPLEKTIIRALH
GPWNTDLPDNVEEVKLLLHMWVALFYSNQNKVIRSSRKVVEHSNPAKYVS

PF12509 // ENSGT00530000063735_1_Domain_4 (1251, 1579)

INSTLESLEF
SEI-EESSNVERCP----VDPLLETNETPRGHAAEVSFPDTNSLLPFLKPPPTRGLELWV
QKERKDIFPREGH-PDTPESQNFIY-SCKNE---VIGEKAKPDSSDKVETSNLV-FSSIG
STQTNGLSVPSEDKTFEPLDSSRV------------------TYSDTVTQTTF-----SK
TYDGLSDQSV--------------------------------------------------
--------------------------------------------------------ICHK
------SVYSTLE-----

ENSGT00530000063735_1_Linker_4_5 (1579, 1613)

KEVDVFHATVQT------ETSALQGLIQHSSPMS

PF12480 // ENSGT00530000063735_1_Domain_5 (1613, 1719)

-KECQPSS
ERT-D-DTEYVIINLEPVTF----------------------TFEENTYVPIQS------
EVVNKTDKPATFNTELIKQVSPASSLRHPVSAFEKAQTQ-------GLRDVPSLAISGEK
DTNYLCASPVSGETLG-NEMCLLQKEIPNVPCSSSPPANSVIAEALSLV-----KSSNCS
LPREEMKLSQEFFLQTQNLFGISSEEIIEPSQVEEVVSASASATSG--GNYSHNCIPSVG
NKAESSSEP-VNDGSGLKSENRNLESFNSAFT-KQTSLSMSKEDGSLES--SEEDSDIDL
ILRISPPTSTREEMPAEELEPQREA-PLSNLELQDMTEEII-RPE-------EVTLLENR
EATSANYISTYPAVPEK-------------------------------------------
-SLESKERKGDNLQTVTLILSKETCALEIAEEVNVTSDFPF-ASLIEEVSPASSPDPEDL
VEAAQPSQTQPEMAVSLCSLQLAGTQGERSDRFSQIESVDLAVTE-------KENSSVG-
LTHPVAQDNLIGVQQMQSSAKMPLVG-SKHPGRKDG-CLSC---PGKVTKEIVPG-----
---------------------------------------EHGE-----GLS--EEVPC--
GDMELS---------------------------QPAS-D---AKYREDF---KLSLEK--
----LVTSGDPLQPVNVQNRNSDLSHLVLE-PGEPPFSPRKIIENKSLADTIVSATTPTG
RVDLSLK-------------------QQPSPKGIKKNLFSSGVKT------NEAVYTQAQ
SLSSGSVGGAD-T-QTHEHSEIPKLAFSSDGS-------RPVNTETGFQTQEISVVKMAS
LLRNNDAEAKLHEEATDLGGVDSQPNTTS-PKDKQKAIHAQQDGAVCETRDLL-------
--------NARPLL----TYVPMDFCLQMAVASENTS-REPCASITPQAC-APL----VC
EVSEEQMANMGSGEGLRAE--EDLDTLGGDVDVSV----NSDIHYEPLSGESDHD-SCGD
GRN-PKMEAEGS-CTLRYSQTKK-EDASKDDSDSFQSL----SNSDNEEWVYST--QAPG
LEVGMAPRHWL--VG----FKKEDRCVPSYVQIRDLRGIPRIYANFTVTRELTDTTRTL-
HSLKRHPSFTAKCGLLSSWTNSWQ-VADDLTQNILDLEYLRFAHKLKQIVKN-GDSRPSA
SSTGVFPKEPPLQIGAEAFPLTKVSESLAL-HPASRSRSPLVVTVVPSGAR---QRS-LR
GRDHALGTLDG---SSFWKESCGRS--RNHLANSE-RNQTGSFHLNKLKYNT--TSKESR
NDVSLILNEYAEFSNMMLNSHLVGFP-EKESAVA-SGEAT-SREVCSPIPR-AASYEDVI
TDLCTSLHVKLKSVVKEACKSPFLFYLVETE-DQSFFVRTKNILRKGGHTEVEPQHFCQA
FHREND--TLLVIIRNEDIASRLHQIPFLLKLKHFPSVLFAGVDCPEDVLQSTYQELFQT
GGFMVSDDKILESLTLAQLKDVVRTLEKLNR--NGRWKWLLHYRENKKLREDVRVDSVAH
KKNLILKSYQSAELIELLHYHQCDSRAATKAEHLKCLLSLQIQHIQARFAVFLTEKPTV-
-SREVFENSGILITDVNNFLE---------NIQNIAAPFKSSYWGGIAVGSAYLREPTSS
ERHTSSLAVHLVPRTQETVTMRCLEVVPAGPRPAAEIPVSC

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------MAASA-HESIFE--LSENALTPLWQGKLIIQ
GCLLCDVSLWSSYGTAVPAQLPHELDFKYVMTISSLKKRLPEAAFRKQNYLEQKVCCQDM
CFRMY

PF12480 // ENSGT00530000063735_1_Domain_2 (426, 522)

EVELSNKQGEKIDKLIEYIKNKQ--------------LAIVKCLEDRGFFILLTS
SALMSETNF--AD-ERVCLHGLHLFHSS------PP-AGLK

ENSGT00530000063735_1_Linker_2_3 (522, 949)

ELKVE---DDISSKVTPVL
PALNCALLEAKKSFTEEGICPNTLVKRSFQELYKVDKSPSLT-AASQDGIKETAFFGQ--
-LSNGFDLAP-PAEKCPLQSFTQLKSYFSDPTGYILEVSTALDLLAERPQSPC-ISDGIC
DAGFSLVMTPDPEFLESEAEVRKETETEKNPEDMSKARQGAVISLNP-ALGRRVQP-KRK
ASLPPAV---------------------Q-SKRVNLCRPFPKRAA-SAGKGSDCPTTLKL
VKGPFPQKRKR-GAEVLTAQFVQTTKLDRKNQEAP--ISKDVPVATSAKRARKQENSPVK
TVPRAKPPVKKSPQKQRVNIVRGNQNPRLKKQPQPAKGETGSQLQSEISSVGQEDV-DI-
NAAQAESISVA-QKDLPENSIVNCDSQALNMLADLALSAATSA-TPPS

PF12509 // ENSGT00530000063735_1_Domain_3 (949, 1130)

EPRNF----PCP
SELPQD-DVLLS-KEHSLHGTSDHEYHRGVKNQKGGLFPKPSTG------RKSPPTSDSA
VSQEEESSVPGSK---------APVEASPALPEETLET---S--EASQSTFVAVEHSYAL
-LAEHSKKHL--QQRGIPGPAFAKNGTKGPEAGTPVGKVMPFRHQQSTS

ENSGT00530000063735_1_Linker_3_4 (1130, 1289)

PLRKLSEDPLP
KCRSQVVSSDPRDFQC-SHTVLSCDGSVKVTFQCETEYVFGLDSKYTNHPLEKTVVRALH
GPWNTDLPDNVEEVKLLLHMWVALFYSSHSKVMRSSRKVVEHSNPAKYVSINSTLESLEF
SEL-EEASSVQRCP----VDPLLETNKS

PF12509 // ENSGT00530000063735_1_Domain_4 (1289, 1582)

PRGPAADASFPDADSLLPFIKPPPTRGLELWV
QNEQKEIFAGEGL-PDTPESQNFIY-SCNNE---VIGGKAKEDSSDNLETSNLV-LSGIG
STQTNGPPIPGEDKAFEPPDSTRV------------------TSGDTVTQTAL-----TK
TYDGISSQSV--------------------------------------------------
--------------------------------------------------------ICQK
------SAYSTLE-----SKADIFHATVQT------KTGTLQGHVQHRSPVN-QERQPSL
ERK-D-DTEYVMINLEPVTF----------------------TFEKNNYVPVQT------
EVVNRTREPTAFTMESIKQVPPATSLRHPVSAFEKAQTQ-------GLRDVPSLAMSRQK
GTKHLCASSVGRETLA-EEVCSLQKEIPV-PGSSSPSDNSVVAEALSLV-----KSSNFS
LPKEEMKLSQEFFLQTPSLFGISSEEVVEPSQVEEVVLAPASATLE--KGYSHDYMPSMG
NTADSSSGL-TDDKSGLQSENRSFESLNSAFT-QPTRLSLNREEASLEF--SEEDSDIDL
TLTISPPTSPREEVPAGRLELQQEA-SASNVELPDVTDEII-KPE-------EVTFIENR
KANSANCTSTYPAVSEK-------------------------------------------
-SLEN-ERKGDNLQTVTLILSKETCALEIAEEVNVTSDFPF-SSLIEEVSPASSPDPQVP
VEGTQLC-----QAVSLCSLKLADTHCEKSDRFSQVESVDSAITE-------KEGSFVS-
PTRPGERDSVPGVHETWLSAG------LPHPGRKDG-CLSL---PSRATEEVVPR-----
---------------------------------------EHGE-----GSSFSEKVPSC-
DT-GLS---------------------------QPAS-A---AQYGDDF---RLSLEK--
----LVTSGIPLQPLNIQNRNSDLNHLVLE-TWESPFSPRKMIENKSLADTFVSTAAPSA
IANVSLK-------------------QEIGPKSIEKNLFSSDLKT------NEGIYVQAK
SLSSGSVGGADAT-QTRRHSGLPRLAFRSHGAAAFPHCSTATNVETGFQTQEIAVVRMAS
LLKNSDTEAKFHEKAIDLGGVDSQLHITS-PEDKQNTIHVLQDGSVCETKDVL-------
--------KAGLSP----TYLHADSYQGTAVTSENSS-REPCASFVPQSH-TPL----IC
GVSEEQMANKGPGEGLRAK--EDSGTLSRDMDLGV----NSDIHYEPLSGESDQD-SCGG
CRN-PQSVVEGS-CSVRCSQTKK-EDAPKDDYDSFLSP----NNSDNEEWGYCK--QSSG
LETGLPPRHWL--CG----LKKEGRCVPSYVQIRDLCGILRTYANFTVTKELKETTKTL-
HSLKRCPGFMAKRGLLSSCTNTWQ-VADDLTQNTLDLEYLRFAHKLKQIVKN-GDSRHSA
SSASVFPKEPPLQIAAGAPPLTKLSEAPAL-RPASRSRSPLVVTVVLSDPR---QQN-LH
RRGQMLGGSDS---SCFWKERCGHG--RNHLTNSE-RNHTVSFHLNKLKYNT--TLKESR
SDISLILNEYAEFNKVMMNSNPVIFP-EKESSAA-PGEAA-SPELYSSLPR-AASYEDMI
TDLCTSLHVKLKNVVKEACKGPFLFYLVETE-DQSFLVRTKALLRKGGHTEMEPQHFCQA
FPREND--TLVVVIRNEDIASHLHQIPCLLRLKHFPGVVFAGVDGPEDVPECTYQELFHA
GGFVVSDDKILETLTLIQLKDMVKTLEKLNG--NGRWKWLLHHRENKQLKEDVRVDLIAR
KKNLILRSYQSANLIELLHYHHCDSRSPTKAEHLKCLLNLQVQHVHARFAVFLTEKPTI-
-SREVFENSGILVTDTTENHSAVSAIPSVENLLAVCSPFNR-------------------
-----------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------MAPPA-H----------KILMSPWKGKLIVQ
DRMLCDIALWSTYGAMIPTQLPQELDFKYVMKVSSLKKRLPEAAFRKQNYLERKVCFQDL
CFNLY

PF12480 // ENSGT00530000063735_1_Domain_2 (426, 522)

EVELSNRQGENIDKLTECIKNKQ--------------LAIIKCLEDRGFFILLTS
SALLSEPDF--GG-KQMGLHGLHLFHSP------LS-TGVK

ENSGT00530000063735_1_Linker_2_3 (522, 949)

DLKVE---DDISMKLIPIL
PALNCALLETKKLLPEERIHPNTLVK-HFQELYKVDRSPSLT-VAPQDRMKDPTFLGK--
-LPSGFDLIP-PAEKCPSESLTQLNSYFSDPSAYILEVSTALDLLAEHPQSPC-VSDGIC
DAGFSLVMTPDPDFPGSEAEVRKETETKKDSEEMLKAKKRVVVPLNP-ASNLRVQP-KRK
ASMPHVV---------------------Q-SKKVNLCHPFPKRTAPRADNSSDSPTTLKL
VKGQFPQKRKR-GAEVLTAQFVQKTKLDRKNQEAP--ISTDVPVPTNAKRARKQEKSPVK
TVPKAKPPVKKSPQKQRVNIVKGNENPRIRKQLQPVKGETASKLQSEISRDGQEDGISI-
NSVQPENSTVA-HNDLPENSIVNYDSQALNMLADLALSSATSS-TPVP

PF12509 // ENSGT00530000063735_1_Domain_3 (949, 1125)

EPRNL----HCS
SELPQN-DVLLS-KENSLRGTSDHEYHRGVKSQKGELLPNPSSD------RKSNSESDLI
VSQDEESLVPCSQ---------APAKAQSALTEEMLES---S--DASQSSSVSVEHSYAL
LLREHSKKNL--QEREIPSPVFPKNGTKSPEAVTPVGKVMPFRH

ENSGT00530000063735_1_Linker_3_4 (1125, 1287)

QPGLLLQQKPPDEPMV
KPKDRQASSRVKKSSC-SRIVFSCDDSVKITFKCETEYAFSLDSKYTNNPLEKTVVRALH
GPWNTDLPDNVEEVKLLLHMWVALFYSNQNKVIRSSRKVVEHSNPAKYVSINSTLESCEL
SEI-EECLGLERCS----ADPLLETN

PF12509 // ENSGT00530000063735_1_Domain_4 (1287, 1583)

EISRAHAAEVSFRDPNCLLPFIKTPLTQGLELCV
QNEQKKTFARKRH-PDTLENQDF-VCSYNNEPFQVIGEEAKQESLDKLETSNLA-LSGVG
STRTNGPSVPNEEEIVQPLDSTRV-----------------ASYSGTVTQTTF-----TR
TYDGTGSQPV--------------------------------------------------
--------------------------------------------------------ICQS
------SVCSTLE-----NKVD

ENSGT00530000063735_1_Linker_4_5 (1583, 1664)

VPDAAMQT------KTGTLQDLIQHGSPIN-NECHPSL
ERK-DDNMECAMINPEPVTL----------------------I

PF12480 // ENSGT00530000063735_1_Domain_5 (1664, 1717)

FEKNTHVPLQT------
EAVNTADEPTTFNKELIKQVSPAASLRHPVSTSEKAQTQ-------GLRDISSLVVAGQK
GSKYLCASSVGRETLD-KEVCSLQKEMPL-PV-SLPSDKAMVMEALSLV-----KSSSYL
LPSEEVRCTQNFLSQTQSLLSLSSEGLVEPTQVEV-DSSSASTALG--KHYSLNCISSGC
HTSGDSLELRKNDKNGPNTENMNFEEFDSVFI-KQRRLSVSR-EVSLEL--SEEDSDIDL
ALTISPPTSPREEMPAGEIEQFEEA-PFSNLELQDVAKEIG-EPE-------EVAVTESR
EVNSADSVSVYPTVSEE-------------------------------------------
-PVENKERKGDNLQPVTVILSKENCTLEIAEEINVTSDFPF-DSVIEEVSPASSPEPPVP
VKETRPY-----QAVTPCILKLHGTQCEKSNRISQRVSEDLGITE-------KENFFVG-
PTHRVGQDNFTQVQQMQVSAEMPLIL-TDHPGRTG--RPTL---PGKVTEEIVSS-----
---------------------------------------EHDE-----GLSFSGKAQCY-
GRE-LN---------------------------QPAS-A---AEYTGDF---GPSPEK--
----LVKSGNPLQPIRVENRNLDLKHLVLE-SSEPPFSPRNVTENMALSDTLVSTAVPSG
I----VK-------------------QQTSPKSSQNNLLTSDLKT------DEGVYLQVK
SLTTASVDGAYST-QGCMCSVVPTLCSSSDSA-TLTHYVRPINAEPAFQAQEIPAVRMAS
LLKNGETEAELHKEITGLGTVGPQSNTKSSLKGERKAIHTLQDVSTCETKELL-------
--------NVGVSS----LCAS--PYQNTADTRENLS-KEPLASFVSESF-DTS----VC
GISTEHIEIENSGEGLRAQ--AGSETLGRDAEVSG----NSDMHYELLSGDSDLD-LLGD
CRN-AKCDLEDS-CTLRGSYTRKKEDVPTDGCESSLNF----HN-NQGDWGCSS--QVPG
MEMSLPPGHWT--TR----VKKEEKCVPPYVQIRDLHGILRTYANFSVTKELKDTMRTS-
HSLRRHPSFTANCDLPSSWTSTWQ-VADDLTQNTLDLEYLRFAHKLKQTIKN-GDSQHSA
SSANVFPKELPTQISIGAFPLTKISEASIL-HPAPRSRSPLLVTVVESDPR---PQG-QP
RRGYTASNLDN---SSSWRERCSHN--RD-LTNSQ-RNQTVSFHLNKLKYNS--TLKESR
NDISLILNEYAEFNKVMKNSNQVVFQ-DKELNDA-SGEAT-AQVMYLPFPGRSISFEDII
IDLCTNLHIKLRSVVKEACKSTFLFYLVETE-DKSFFVRTKNLLRKGGHTEIEPQHFCQA
FHREDD--TLIIIIRNEDISSHLHQIPSLLKLKHFPSVIFAGVDSPGDVLDHTYQELFRA
GGFVITDDKILEAVTLVQLKEIIKILEKLNG--NGKWKWLLHYRENKKLKEDERVDSTAH
KKNIMLKSFQSANIIELLHYHQCDSRSSTKAEILKCLLNLQIQHIEARFAVFLTDKPTI-
-PREVFENSGILVTDVNNFIE---------NIEKVAAPFRTSYW----------------
-----------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------MATPT-YKSLLQL--SQNALISPWKGQLIIQ
GCLLCDITLWSTHGTGIPVQLPQELDFKYVMKVSSLKESLPEAAFGRQNYLEQKVCCQDL
CFDLY

PF12480 // ENSGT00530000063735_1_Domain_2 (426, 522)

EVELSNKQGENIDKLIRYIKNKQ--------------LAIIKCLEDGGFFILLTS
SALTPEPDF--GD-KQMGLHGLHLFHSP------QS-TGAK

ENSGT00530000063735_1_Linker_2_3 (522, 958)

DLKVE---DGISLKVIPIL
PALSHALLEAKKSLPEKGIPPNILVKHSFQDLFKVDKSLSLM-AL-RDEMKDTAFKGK--
-LSHAFDLAP-PLEKCPSESLTQLKSYFLDPSGYTLDLSAALDLLAEHPQCPC-ISDGIC
DAGFSLVMTPDPEFLDSEMELRKETETSKKSGKPLRVKKRAVALLTP-ASNLRVQP-KRK
ASTSAVM---------------------LPNKRVSLGRPLSKRTASKADSGS-CNPTLKL
VKGQFPQKRKR-GAEVLTAQFVQKTRLDRKKQEA--SVSKDAPVATNAKRAKKQEKSPGR
VVSRPKPSVKKSTQKRKVNVARGRRNPRTRKQPQPAEKDIALHLQSEISSNGQIDGTNL-
STAQQESITVI-PKGFPENSIVNCDSQALNMLADLALSSAASS-IPSSELRTV----

PF12509 // ENSGT00530000063735_1_Domain_3 (958, 1130)

PCF
PELPQN-NVLLS-KENSLHGTTDHEYHRGVKNQKGILLPKPSSD------EKIDSKLDLP
FSQE-ENMVPCAQ---------PLAIAQPAPAEEARES---S--DASQNS-VAVEHSYAL
LLAEQSKKHL--HQRKLPSPAFAKNGAKGPEAGTPIGKVMPFRHLQNTSPLQKRSEDSLT
KRKSLFVSSSIKDVFC-SHTVLSCDGSFKITFKCEGEYAFNLDSKYTSNSLEKTVVRALH
GPWNTDLPENMEDVKLLLHMWVALFYSKKNKIMGSPRKVVEHRNPAKYVCINRSVESFDQ
SEI-EEFSSVERYS----IDHLLETKEAYEGHATNMTFPGPNCVLPFISPPTTRDLELCV
QNEQKEMFTGECH-LDTSGSQNFTY-SCNNE---VTGGKDKQELPCIPETSNVG-LSGVT
SAQSNGSCIPSEDKTLQS---TKM-----------------VSCNDSVTQATL-----TT
TYEGARSESM--------------------------------------------------
--------------------------------------------------------MCQK
------SVVGNLE-----NKDDTLHPSLLK------KTGAVQDVIHHSSPVN-NNYTPSV
ERT-DDDVEYMMINLEPVTL----------------------AFEKTAYIPIHK------
-EVNTADKPTGFNTELVKQVSSALSIQYSLSTLEKAQTE-------CPRDIPSLAISEYK
ASKCLSASSLKKKTPP-ESLGPLQKEIPP-PT-SA--DEGLITEALPLV-----KSSSYS
LANDKTKCPQDSFLQTQNGFRMSLDEVLEPSQVKA-SS-PTSATLG--KKQSLNCIPAIS
NVSDDSSEVRNNDKSSLNQEK-ALQTFNSLFP-KQTDLSMNKEEVSRKL--SGEDSDIDL
TLTVSPHPSSREEMAAGEIKQLQRA-PISNLGLQSRTEEMVEPEA-------QVSHIKNE
EISSASFMSVFPVEPRE-------------------------------------------
-PLKET--QSSDLKPGTLILSKENCSPEVTEEINVPSGFPF-GPLIEEVSPASSPDPIVQ
TEETQPS---------PCCLKPHGAESEKSSNFSQIKSGDLTIPE-------KGNSFVG-
PKPSMGQDKLPQVQ-VQISAEMPQIL--NNAGIEG--RVTV---PGEITEFSVPS-----
---------------------------------------EHNE-----NLSFSEKVQCY-
DT-ELS---------------------------KSTS-P---PKYRGNF---K-PLEK--
----LIESGNPLQAVCMENRNLDIKPFALE-SIVPSCSPRKVVENKSLADTLVSVTTVNA
IVDMSLK-------------------E-TSSKKN-KNICDSDLKT------EGDTNKQAG
SVNSASIDKTDVV-PANMHPEISNFVSSSDHA-QCTYFTKPVSVEPGFQTQEIQ---TSS
LLQNVG--TELHEERMDLSAIGLHSNSTS-TKGEQKTIHVLQDTSKCEEEKPL-------
--------NDGISP----QNA--HSSQNTADISKSIN-EEPSASFVTESV-NS-----VC
GVYKEHIVSENPNMGHKTK--ADSETLSRNTEISV----NASMCYGPLSEDTDQD-SL-D
CRN-CKLDSENL-CTLRGCHANQ-KDAVKDSNDSFTGL----NISDNNTWVYSN--KISE
LETHIPCRSWD--TELCP-ISTN-KCMPRYVQIPDSHGIPRTYANFTISKESRDTTRTL-
HSLKRHRNFTANCGLLSSWTSTWH-VADDLTQNTLDLEYLRFDHKLKQIVKK-VDSQQAS
PNTSSFSEESLIQISVRTHPSTQTADASLL-RLPAKSRSPILVTVGHSDTR---QQS-HR
RRSHSPSNLDS--SSFFWREQCSQS--RN-LKNSE-RSHTVPVHLNKLKYNS--TLKEGR
NDISLILNEYAEFNKVMMNSDQIVSQ-EKELSVA-SAEAV-SQE--TCQPRQSVSYKDVI
TDLCATLHIKLKGVMREACKSPFWFYLVETE-DKSFFLRTKSILKKGGHSEIELLDFCQA
FQGENE--TLLVIIKNEDIMSHLHQIPSLLKLKHLPSVIFAGVDSPEDILNDTYQELFRS
GGFVVSDDNILESLTLVQLKEIVTILEKLNE--NGRWKWLLHYRENKKLKEDVRVDSIAH
KKNLILKSYQSVNIIELLHYHNCDSPSPTKAENLKCLLNLQVQHISARFAVFLTDKPTV-
-STEVFENNGILVTNVNYFTE---------NIQKIAAPFRSSYW----------------
-----------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------MAAPP-HKSILE--SSKNVLISPWKGKLTIQ
GCVLCDITLWSSYGTVIPAHLPHELHFKYVMRVSSLKERLPEAAFRKQIYLEQKVCCQDL
CFNLY

PF12480 // ENSGT00530000063735_1_Domain_2 (426, 522)

EVELSNKQGEEVDKLTEYIKNKQ--------------LALIKCLEDRAFFILLSS
SALIPEPDT--GD-EQMSLHVLHLFHSH------LA-TEVK

ENSGT00530000063735_1_Linker_2_3 (522, 949)

DLKIE---DDISWKVAPIL
PALNCALLEAKKLLPEEGTHPNILVKHNFQELNKVDKNLSLT-AAPQDVKKETTFFRK--
-LSGSFDLVP-PPEKCSTESLTQLKSYFSDPGGYTLEVSTALGLLAECPPSPY-ISDGIC
DAGFSLVMTPDPEFLDSEAEVRKKTQTEKSSEEMFKEKKGAVVPLSA-ASNLRVQP-KRK
ASMLPIV---------------------R-SKRVNLCPSFAKRTTPGTDSRSSSPSPLKL
VKGQLPQKRKR-GAEVVTAQVVQKTKLNRKSQEVP--ISKDVPVATNTKRARRQEKSPIK
TVPRAKPPVKKSPQKRRVNIVKGSQNPRIGKQPQPAKEETALQLQSEISSDGQKDGISM-
NTAQSQSITVA-QKDLPENSIINYDSQALNMLADLALSSAASS-TPLC

PF12509 // ENSGT00530000063735_1_Domain_3 (949, 1130)

EARNL----PCS
SELPQN-DVLHS-KESSLCDTSDHDYHSGVKSQKGILLSKSSCD------QKSNSGLDLT
ASHEEENLVPCSQ---------TPPNAQSALREE-TEP---S--GTSQNSLITVEHSYAL
LLGENSKKHL--QQRGLPGPAFAKTGTKGPEAGTPVGKVMPFRHLQNTS

ENSGT00530000063735_1_Linker_3_4 (1130, 1287)

PLQKLSEDSLV
KHRGRFISSNLKNIFC-SHTIISCDGSFKITFKCETEYAFNLDSKYTNNPLEKTVVRALH
GPWNTNLPDNMEEVKLLIHMWVALFYRNRNKVIQSSRKVVEHSNPEKYVSINSTLESFEL
SEI-EESSSVERCS----IEPLLETK

PF12509 // ENSGT00530000063735_1_Domain_4 (1287, 1572)

EMSRAHANEVSFHGPKCLLPLIKLPPSRGLELCV
ENERKEIFARECH-LDNSESQNFIH-SCNDE---VVGGKAKQESANKLEASNLV-LSVIG
NTQTNGPFSSDEDETFQSVDSKRV-----------------VSYNDTGTQATF-----TR
TYDGASSQSE--------------------------------------------------
--------------------------------------------------------MCEK
------SVYIPLE-----SRVDILHTTVQT------NTNALQDLIQCSSPIN-NECESSL
EKT-DDNMEYVMINLEPVTF----------------------TLEKDACVPVHT------
-EVNRGEKPLPFSSELINQMLPAADVRHPISALEEAQTQ-------AVRDIPSLAMAGQK
STKYLSASSGKREILD-EELLLSQKEMTL-PVSSPSSDKALIMEALSLV-----KCSSYP
LPSEEMKHSQDICLQTQNLFSISSEEIIEPSQIEV-VSPSVSASLG--KRYSNDCVPPKT
NIPDDSLELRKNDKSSLNCENVNLESFNAVFA-KQTNLLINGQEIGLEL--QEENSDIDL
TLTISPPTSPRGKVPANETKQLQEA-TGSNLELKDIAEEII-EPK-------EVTLIEKT
EENPASSMSAYSTVSKE-------------------------------------------
-PLEN-ERKGDSLQPITLILSKENCTLEIGEEINVTSDFPY-GSLIEEVSPSSSPDPLVP
IEEARPS-----QVVSPCSLKLHGTQCEKSNKFSQIESEDIAVTE-------KENSFVD-
PSHLVRQENTTQLQQIQLSVKMPLIL-TNHPGRKG--RLMF---PGKITEEIVPR-----
---------------------------------------EHGE-----GLSFSEKVQCY-
GT-ELN---------------------------KPGL-I---ANYGDNF---KPSLEK--
----LVKSGNPLQPISIENRNLGLKHLVLE-SHEPSFSSRKSIENKSLAEALVSTTSLSG
IVNIPLK-------------------EQGSPESIKEKLCNSDLKT------DGGSYMQVK
SVSSVSIDEADVT-QAYLHPEIPEFGSASDSA-TFTQCTRPESIEPGFQTQEISVIRMAS
LFGNSRTEAELHEEGTDVDAISLQSNSTASTKGEEKTVHTLSDTSVCEMKELL-------
--------KGEFMP----TYAC--SYQSTIDTSE----EP--SAFVSESI-ETL----VY
GVSKEHIDRKTTSEGHRNE--ADAKILDRNVDANM----NSDKHYEPLSGDSDQD-SFNN
CRN-PRLDMENS-GILG-SYTSKNEHAAKDGYYSLMCL----NNSDNEACDYSN--KVPG
VKMNIPPRNWA--TG----LKKADECMPHYVQIRDRHGILRTYANFTVTRELKDMTRTL-
HRVRRHPSFTLNSDL-SSWMSTWQ-VADDLTQNTLDLEYLRFTHKIKQLVKKEGSRQ---
-------TDSPLEILLRDFPLTEKSEPPVL-HPTPRNRSPILVTVMHTDARW---QS-CH
RSGHTPSDLDS--SSSFWKERCSHS--RN-LTNSQ-RKQTVSFHLNKLKYNS--TLKESR
NDISLILNEYAEFNKVVMNSNYADFQ-DKELNMA-SEEAT-FQETYPSFSRQSTSYEDII
TDLCASLHTKLNSVLKEACKSPFFFYLVETG-DKPFFLRTKSILRKGGHTEIEPQHFCHT
FHREND--TLVVIIRNEDISSHLHQIPSLLKLKHLPGVIFAGVDNPEDVLNDTHQELFHT
GGFVVSDDKILETVTLAQLKEIVKILEKLNG--NGRWKWLLHYRENKKLKEDVRMDSVAH
KKNLILRSYQSANIIELLPYHQCDSQSQTKAEILKCLINLQIQHVDARFAVFLTDKH-I-
-SSEVFGNNGILATDVNNFIE---------NIQKIAAPFRSSYW----------------
-----------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------MAPPA-HKSIFFFTFISSVLMSPWKGKLIVQ
DRMLCDIALWSTYGAMIPTQLPQELDFKYVMKVSSLKKKLPEAAFRKQNYLEQKVCFQDL
CFNLY

PF12480 // ENSGT00530000063735_1_Domain_2 (426, 522)

EVELSNRQGENIDKLTECIKNKQ--------------LAIIKCLEDRGFFILLTS
SALLSEPDF--GG-KQMGLHGLHLFHSP------LS-TGVK

ENSGT00530000063735_1_Linker_2_3 (522, 949)

DLKVE---DDISMKVIPII
PALNCALLETKKSLPEERIHPNTLVKHHFQELYKADRSPSLT-VAPQDRMKDPTFLGK--
-LPSGFDLIP-PAEKCPSESLTQLNSYFSDPSAYILEVSTALDLLAEHPQSPC-VSDGIC
DAGFSLVMTPDPEFLVSEAELRKETEMKKDSEEMLKAKKRVVVPLSP-ASNLRVQP-KRK
ARMPHVV---------------------Q-SKKVNLCRPFRKRPVSRADNSSDSPTTLKL
VKGQFPQKRKR-GAEVLTAQFVQKTKLDRKNQEAP--ISKDVPVPTNAKRARKQEKSPVK
TVPRAKPPVKKSPQKQRVNIVKGNENPRNRKQLQPVKGETASKLQSEISRDGQEDGISI-
NSVQPENTTAA-HNDLPENSIVNYDSQALNMLADLALSSATSS-TPVS

PF12509 // ENSGT00530000063735_1_Domain_3 (949, 1125)

EPRNL----HCS
SELPQN-DVLPS-KENTLRGTSDHEYHRGVKSQKGELLPNPSSD------RKSNSGSDLT
VSQDEESLVPCSQ---------APAKAQSALTEEMLES---S--DASQSSSVSVEHSYAL
LLTEHSKKHL--QEREIPNPLFPKNGTKSPEAATPVGKVMPFRH

ENSGT00530000063735_1_Linker_3_4 (1125, 1287)

QPGLLLQQKPPDEPMV
KPKDRPTSSRVKKSSC-SRIVFSCDDSVKITFKCETEYAFSLDSKYTNNPLEKTVVRALH
GPWNTDLPDNVEEVKLLLHMWVALFYSNQNKVIRSSRKVVEHSNPAKYVSINSMLESCEL
REI-EESLGLERCS----ADPLLETN

PF12509 // ENSGT00530000063735_1_Domain_4 (1287, 1583)

EISRAHATEVSFRDPNCLLPFIKTPLTRGLELCV
QNEQKKTFARECD-PDTQENQNF-VCSYNNE---VIGEEAKQE---SLETSNLV-LSGVG
STQTNGPSVPSEEEIVQPLDSTRV-----------------ASYSGTVTQATF-----TR
TYDGPGSQPV--------------------------------------------------
--------------------------------------------------------ICQS
------SVYSTLE-----NKMDVLDAAMQT------KTGTLQDLIQHGSPIN-NECQPSL
ERK-DDNLGCAVINPEPVTL----------------------TFEKNAHVPIQT------
EGVNAADEPTTFNKELIKQVSPAASLRHPVSTSENTQTQ-------GLRDIPSLVVAGQK
GTKYLCASSVGRETLD-KEMCSLQQEMPL-PV-SLPSDKTMVMEALSLV-----KSSSYL
LPSEEVRCTQDFLSQTQSLLSVSSEGLLEPTQVEV-DSLSASTTLG--KHCSLNCISSGC
HTSGDSLELRKDDKNGPNTDNMNLEAFDSVYI-KQTSLSVSR-EVSLEL--SEDDSDIDL
ALTISPPTSPREEMPAGEIEQFEEA-PFSNLELQDVAEEID-EPE-------EVALTESG
EVNSADNVSVYPTVSEE-------------------------------------------
-PVENKERKGDNLQSVTLILSKENCTLEIAEEINVTSDFPF-DSVIEEVSPASSPEPPVP
VKETRPY-----QAVTPCILKLHGTQCEKSNRISQCESEDLGITE-------KENVFVG-
PTHPVGQDNFTQVQQMQVSAEMPLIL-TDHPGRTG--RPTL---PGKVTEEIVSS-----
---------------------------------------EHDE-----GLSFSGKVQCC-
GRD-LN---------------------------QPAS-A---AKCTGDF---SPSPEK--
----LVKSGNPLQPVSIENRNLNLKHLVLE-SSAPPFSPRNVIENKSLSDTLVSTMAASG
IVNVSVK-------------------QQTSPKSSQNNLFPSDLKT------DE-------
---------------GCMCSVVPTLCSSSDSA-TLTHYVRPINAEPAFQAQEIPAVRMAS
LLKNGETEAELHKETTGLGTAGPQSNTTSSLKGERKAIHMLQDVSTCETKELL-------
--------NVGVSS----LCAG--PYQNTADTKENLS-KEPLASFVSESF-DTS----VC
GIATEHVETENSGEGLRTE--AGSEILGRDAEVSV----NSDMHCELLSGDCDLD-LLGD
CRN-PKLYLEDS-YTLGGSYTRK-KDVPTDGYESSLNF----HNNNQEDWGCSS--RVPG
METSLPPGHWT--TG----VKKEEKCVPPYVQIRDLHGILRTYANFSITKELKDTMRTS-
HSLRRHPSFTANCSLPSSWTSTWQ-GADDLTQNTLDLEYLRFAHKLKQTIKN-GDSQHSA
SSANVFPKELPTQISIGAFPSTKISEASIL-HPAPRSRSPLLVTVVESDPR---PQG-QP
RRGYTASNLDS---SSSWRERCSHN--RD-LTDSQ-RNDTVSLHLNKLKYNS--TVKESR
NDISLILNEYAEFNKVMKNSSQFVFQ-DEELNDV-SGEAT-AQEMYLPFPGRSASYEDII
IDVCANLHVKLRSVAKEACKSTFLFYLVETE-DKSFFVRTKNLLRKGGHTEIEPQHFCQA
FHREND--TLIIIIRNEDISSHLHQIPSLLKLKHFPSVIFAGVDSPGDVLDHTYQELFRA
GGFVISDDKILEAITLVQLKEIIKILEKLNG--NGRWKWLIQYRENKK------VDSTAH
KKNIMLKSFQSANIIELLHYHQCDSRSSTKAEILKCLLNLQIQHIDARFAVLLTDKPTI-
-PREVFENSGILVTDVNNFIE---------NIEKLAAPFRSSYW----------------
-----------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------MSTLG-HKNMIE--FDDEVLISPWRGQLTIQ
GQLICDLTLWSPHGAVIPAQLPRQLDAKYVMEVSTLKKKLPESAFRKSNYLEEKVCYQDL
CF

PF12480 // ENSGT00530000063735_1_Domain_2 (423, 521)

SMYEVETSNKQGKKLDQLTEYIKTKE--------------LAIIKCLKDHGFLILLTS
SALLWDTDF--GD-EHMNLYALFLFPSS------LT-TGRKEPKCE---DDISGRVVHIL
PTLHYALLEAKKFLSEEEMHPNVLVKHHLQEISKLKKNSSLS---PPNTFEEPEFFPSDT
SS-DEFKSDHHF-EKCTEKSLNCLKSYFSNPNGYALEITTALDLLTRHSPSSFSVSEGIC
DVGFSLFMPPDSEFVDLEAHMKKELEKSKNSEGLGKA-NGDSLQLCP-ASNLRVQP-KRK
ASMSVVM---------------------Q-NKKVNLCRPFSKKTGPVT----TIETTVKL
AKGQFPQKRKR-GAEVLTAQFIQTTRLDQKSQETS--VSESVPVVMNAKKVKKPETSPIK
TVPRVSHAMKKPPQKQRVNIVKSNQNPRMRKQLQPAKREISSQPPVKILSNNQGHDNSE-
NTAPLGNTAVV-QSDLQGNCIGHFDSQALNMLADLALSSATST-TTSSIHRDL----SSS
SDLAQNNNILFY-KENPLQGTYDHEYHRLAKNQRCALYSLELSKPSY---EQTDSRTNLP
DSQREKNLTH-------YSQISVTQE---ALPKDTLDS---ADESTSTSSFIAIEHSYAL
LTAEHSKKHL--QQRGTQGPTFAKNGTKGPEAGTPVGKVMPFRHQHNTPPVQKLLQDPII
KPKTRLLPSNLKEDFCHSHTVFSCDGSFKVTCKCETEYVFSLDSKYTNNPLEKTVIRALH
GPWNADVPDNVEEVKLILHMWVALFYSNQNKVIPSARKVVEHSNPAKYVSINSTLDPLDF
SEVSEECLGMKRHS----VDSPLETSWTSSSSTPGILLSCTNIKPSTSGLEEKATLAGED
HQD----------AP---EFQSTI-CSN-NE---IIRKRTEQELPSNVEPPNIV-LSSNA
STQTREPSVADENENSQKLVNSRT-----------------VSQNGINDQTMICETSVNR
ALENRDDP------VYEALGTKANN-----------------------------------
--------------------------------------LQN-------------------
---------ITEHNSPRNKVTESQ--------------------------ES-------L
ENK-DGDLEYVMINLEPITF----------------------TFEKNACLPIEA------
GFTNGSDKVPDTDRELMKKVSPVESLRQQIPFHEMAQAQSASSANQDLQDISSLAASAST
GTKYLCTSSGTREILA-KDTGSLQKEVPI-PLATSSSNTVLIEAV------TSVVNSGEQ
ATSNEIKLPRDTFLQTPGLYSISSEEVIESSQVEEIVLAPTFAPLESKQTGSAGYIPSRS
TKLKYPLEK-ETNESDLNSERMNFESVNLAFT-KETCISLGREAVSI-E--LSDDSDIEL
ALTISPPTSPRDQAQSDEIMQIQAV-PLENVELQVVAEEIIDPV--------NTTFPKNK
ET-NSDYSSLCTSV--------SHK------------------------------P----
--LENKECKRDAIEPVTLVLAKESCTLEIGQEVNIISNSPFDGALIEPVSPASIPDDQMT
SKETTLS-----QDMPLQMLELHSTISKEVNKATQIQ-------------SVDLA-----
----EEE--NA--S----------VS-HILPEGKQ---TVTQGKLTKLSPEL------AL
PLIDY-TEQKESHLVLRRRAAEDSVA-QNKYDDSRFFP---GK------------FQCC-
DAALN----------------------------QIAS-VTKYEDY-------KTSFQE--
----LERSENSLKQTSEENKNLDLTNTVLD-TQKAPLCLRKLIENRSFAEKSHSSAESGV
KSN-SLD-------------------HKTSPLNNRKDLHDCILKQ------NESDYLHNK
SLNSTPVDQSDFIQMCT-TSKNPDICISMDTA-SHKSNSGQP-NE-SSQEHGISLVKIL-
--NNDKVTTSLHEESISFKGIGPGSNLIPLSKAEGKTPVHQE-VSVCETKNQS-------
---------GGIFATKESNLACSGAYQDKANVTRNSE-EEYSALTTQKPS-WEA-----S
KEIMEHE---NVIEKIGNE--KDVKSPDRNMNTDL----NTEIYYESLSGESDQE-CFGD
IKL-PQYQSEDS-CPLKTSHPNKVEEATITNYDTLVHNRTITASNDIDSWNYSH--KGPV
ADEGTQERSWS--S---G-LKKGDKYVPFYIKIRDLHGTPRSYTNFTVTKKLKDTTRTL-
HNLKQHPCATARCGLISSWTSTWQ-VADDPTQNTLDLEYLRFVHKLKQMVKK-GKSQLST
TTPNPLTKESHIQTAVGVFPLTKVTETPVT-HPTSRSRSPLLVTIVHSEPRQHTSS--WH
TKSHKRGDFDSLSSPSGQ-DKCGSQ--SRNIPNAE-RDPASSFHLNKLKYDS--KLKESR
NDISLILSEYAEFNKVMLNNSQRNYQ-TNDLSL--T-SGKATSPKVSSFPRRMASYENMI
TDLCSNLHIKLKSVIKEACKSTFLFYLVETE-DSSFFIRTRNLLRKEGHKEIEPQHFCQA
LHRDTD--TLVVIIKNEDISTHVHQIPSLLRLKQFPSVMFAGVDSPGDVLDCTHQELFRT
GGFVVSDDKVLEAVTLVQLKEIVKILEKLNA--NGRWKWLLHYRESKKLKEDVRVDSIAH
SKNSILKSYQSANIIEVLHYHQCDSKSSTKSEYLKCLLNLQVLHINARFAVYLTDKLST-
-SREIFENNGILVTDISNFVG---------IVQK-AAPFKATYW----------------
-----------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------MAPPA-HKSILE--RSENVLMSPWKGKLIVQ
DRMLCDIALRSTYGAMIPTQLPQELDFKYVMKVSSLKKSLPEAAFRKQNYLEEKVCFQDL
CFNLY

PF12480 // ENSGT00530000063735_1_Domain_2 (426, 522)

EVELSNRQGENIDKLTECIKNKQ--------------LAIIKCLEDRGFFILLTS
SALLSEPDF--GG-KQMGLHGLHLFHSP------LS-TGVK

ENSGT00530000063735_1_Linker_2_3 (522, 949)

DLKVE---DDISMKVIPIL
PTLNCALLETKKSLPEERIHPNTLVKRHFQELYKADRSPSLS-VAPQDRMKDPTFLGK--
-LPSGFDLIP-PAEKCPSESLTQLNSYFSDPSAYILEVSTALDLLAEHPQSPC-VSDGIC
DAGFSLVMTPDPEFLVSEAEVRKETETKKDSEEMLQAKKR-VFPLSP-ASNLRVQP-KRK
ASMPHMV---------------------Q-SKKVNLCRPFPKRTASRADNSSDSPTTLKL
VKGQFPQKRKR-GAEVLTAQFVQKTKLDRKNQEAP--ISKDVPVPTNAKRARKQEKSPVK
TVPRAKPPVKKSPQKQRVNIVKGNENPRNRKQLQPVKGETASKLQSEISRDGQEDGISI-
NSVQPENTTAA-HNDLPENSIVNYDSQALNMLADLALSSATSS-TPVS

PF12509 // ENSGT00530000063735_1_Domain_3 (949, 1125)

EARNL----HCS
SELPQN-DVLLS-KENSLRGTSDHEYHRGVKSQKGELLPNPSSD------RKSNSGSDLT
VSQDEESLVPCSQ---------APAKAQSALTEEMLES---S--DASQSSSVSVEHSYAL
LLTEHSKKHL--QEREILSPLFPRNGTKSPEAATPVGKVMPFRH

ENSGT00530000063735_1_Linker_3_4 (1125, 1287)

QPGLLLQQKPPDDPVV
KPNDRPTSARVKKSSC-SRIVFSCDDSVKITFKCETEYAFSLDSKYTNNPLEKTVVRALH
GPWNTDLPDNVEEVKLLLHMWVALFYSNQNKVIRSSRKVVEHSNPAKYVSINSTLESCEL
REI-EESLGLVKCS----ADPLLETN

PF12509 // ENSGT00530000063735_1_Domain_4 (1287, 1583)

EISRAHAAEVSFRDPNCLLPFIKTPLTQGLELCV
QNEQKKTFARECD-PDTQEDQNF-ICSYNNE---VIGEEAKQE---SLETSNLV-LSGIG
STQTNGPSVPSEEEIVQPLDSTRV-----------------ASYSGTVTQATF-----TR
TYDGPGSQPV--------------------------------------------------
--------------------------------------------------------ICQS
------SVYGTLE-----NKVDVLDAAMQT------KTGTLQDLIQHGSPIN-NECHPSL
ERK-DDNMGCAVINPEPVTL----------------------TFEKNAHVPIQT------
EGVNTADEPTTFNKELIKQVSPAASLRHPVSTSENAQTQ-------GLRDIPSLVVAGQK
GTKYLCASSVGRETLD-KEMCSLQKEMPL-PV-SLPSGKTMVMEALSLV-----KSSSYL
LPSEEVRCTQDFLSQTQSLLSLSSEGLLELTQVEV-DSSSASTTLG--KQCSLNCISSGC
HTSGDSLELRKNHKNGPNTENMNLEAFDSVFI-KQTSLSVSR-EVSLEL--SEEDSDIDL
ALTISPPTSPREEMPAGEIEQFEEA-PFSNLELQDVAEEIG-EPE-------EVALTESR
EVNSADNVSVYPSVSEE-------------------------------------------
-PVENKERKGDNLQPVTLILSKENCTLEIAEEINVTSDFPF-DSVIEEVSPASSPEPPVP
VKETRPY-----QAVTPCILKLHGTQCEKSNQISQCESEDLGITE-------KENVFVG-
PTHPVGQGNFTQVQQMQVSAEMPLIL-TDHPGRTG--RPTL---PGKVTKEIVSS-----
---------------------------------------EHDE-----GISFSGKVQCY-
GRE-LN---------------------------QPAS-A---AKCTGDF---SPSPEK--
----LVKSGNPLQPVSIENRNLDLKHLVLE-SSEPPFGPRNVIENKSLSDTLVSTTAPSG
IVNVSVK-------------------QQTGPKSSQNHLFPGDLKT------DEGIYLQVK
SLTAASVDGAYST-QGCMCSVVPTLCSSSDNA-ILTHYVRPINAEPAFQAQEIPAGRMAS
LLKNGEPEAELHKETTGPGTAGPQSNTTSSLKGERKAIHTLQDVSTCETKELL-------
--------NVGVSA----LCAG--PYQNTADTKENLS-KEPLASFVSESF-DTS----VC
GIATEHVEIENSGEGLRAE--AGSETLGRDGEVSV----NSDMHYEL-SGDSDLD-LLGD
CRN-PKFDLEDS-YTLRGSYTRK-KDVPTDGYESSLNF----HNNDQEDWGCSS--WVPG
METSLPPGHWT--AA----VKKEEKCVPPYVQIRDLHGILRTYANFSITKELKDTMRTS-
HSLRRHPSVTANCGLPSSWTSTWQ-VADDLTQNTLDLEYLRFAHKLKQTIKN-GDSQHSA
SSANVFPKESPTQISIGAFPSTKISEAPFL-HPAPRSRSPLLVTVVESDPR---PQG-QP
RRGYTASSLDS---SSSWRERCSHN--RD-LRNSQ-RNHTVSFHLNKLKYNS--TVKESR
NDISLILNEYAEFNKVMKNSNQFIFQ-DKELNDV-SGEAT-AQEMYLPFPGRSASYEDII
VDVCTNLHVKLRSVVKEACKSTFLFYLVETE-DKSFFVKTKNLLRKGGHTEIEPQHFCQA
FHREND--TLIIIIRNEDISSHLHQIPSLLKLKHFPSVIFAGVDSPGDVLDHTYQELFRA
GGFVISDDKILEAVTLVQLKEIIKILEKLNG--NGRWKWLLHYRENKKLKEDERVDSTAH
KKNIMLKSFQSANIIELLHYHQCDSRSSTKAEILKCLLNLQIQHIDARFAVLLTDKPTI-
-PREVFENSGILVTDVNNFIE---------NIEKIAAPFRSSYW----------------
-----------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------MAAPT-YKSTLEL--NKNALVSPWKGQLIIQ
GCVLCDVTLRSTYRTEAPGQLPQELDFKHVMKVSSLKESLPEAAFRRRNYLEQKVCCQDL
CFDLY

PF12480 // ENSGT00530000063735_1_Domain_2 (426, 522)

EVELSNKQGENIDKLMEYVKNKE--------------LALIKCLEDRGFFILLTS
SALIPEPDF--GD-EQLGLHALHLFQAP------QA-AGSK

ENSGT00530000063735_1_Linker_2_3 (522, 951)

DLKVE---DGISLKVIPIL
PALSYALLEAKKSLSEEAIPPNILVKHSFQDLYKVDKSLSLM-APPQDGLKDAAPTGG--
-LPHAFDLAP-ALETCPSESLAQLKCYFSDPAGYTLDLSAALDLLPEHPQFPC-ISDGVC
DAGFSLVMTPDPEFLDSEMEIRKETETAEKPGRTLKVKKKGVTPSTP-SSNQRVQP-KRK
ASTSVIT---------------------LPSKRVSLGRPTSKRTAPRTD-RS-CNPTLKL
AKGQFPQRKRE-GAEVLTAQIVQKTRLERKKQDV--SVSKDGPVPANAKRAKKQEKSPGR
VASRPKPPVKKSPQKRKVNVARGRRNTKVRKQLQPAKKEIALHLQSEMSLDGQKDGLNLL
STSQPESIAVI-PKGPPENSIVSCDSQALNMLADLALSSAASP-IPSCEL

PF12509 // ENSGT00530000063735_1_Domain_3 (951, 1130)

RSF----PCF
SELPQN-NVLLT-KESALHGASDHEYHKGVKSQKAVQLPKPYSD------EKISSESNLT
HSQE-ENLVPSAQ---------PLAVAQSAPHEEAQEF---S--DASQNS-VVVEHSYAL
LLAEQSKKHL--HPRKLPSPGFVKNGAKGSEAGTPIGKVMPFRHLQSASPLQKHSEDSLT
KRKSPFVSSSLREFFC-SHTILSCDGSFKITFKCEGEYVFSLDSKYTSNPLEKTVVRALH
GPWNTDFPENMDDVKLLLHIWVALFYSKKNKAVGSPRKVVEHKNPAKYVCINRSLESLDH
SEI-EEFSNVERPSVGGSVDPLLETKETHIGHATNMTFPGPKRVLPFINPPTTRDLELCV
QNDQKEVFTGECH-LDTSGSQNFIY-SCNTE---VTGGKAKQELSNKLETSNVV-LSGVV
SAQSNGTCIPSEDKACQS---TKV-----------------VSCRDTVTQATL-----TT
AYDGASSESMRQKSVFHNLENKVDT-----------------------------------
------------------------------------------------------------
-----------------------FHPSLLI------KTGAVQDVIQHSSLIN-NECQPSV
ERR-DDSVECMMVNLEPVTL----------------------AFEKSASVPVHT------
-EVNTADKPTGFNTELVKQVPPALSIQSPVSALEKVETQ-------SPRDVSSLAMSEYK
DSTCLSASSVNEETPP-ESLCLLQKEIPL-T-SPA--DKGLIMEALSLV-----KSSSYS
LASDKTKCPQDVSLQTQNGLSMSSGEVLEPSQVKV-VS-STSVTLR--AQQSPNCISVTS
DVAGGSSEIMNSDNSSLNQKK-VLQIFNSVFP-KETDLSLNREEVSMEL--SGEDADIDL
TLTISPPTSPSEEIAAGEIEQLQRA-TGSNVGQQSRPEEMVEPEQ-------QGSHIKNR
EISSAGCISVYPVESKE-------------------------------------------
-MSK-------------------NYTPEVAEKVNVTSDFPF-GPLIE-VSPASSPDPIVQ
TGDRQSS---------PCCLKLQDSQSEKTNTFSQIKSGDLTIPE-------KESSLVG-
PKSPKEQDKLAQTQ-VQLSAEMPQIL--TNAEIEG--RDAV---PGKVTEVTVPS-----
---------------------------------------EH-E-----NLSFSEKVQCY-
DT-ELN---------------------------KPTS-P---AKYGGNF---K-PLEK--
----PVKSGNSLEADCMENRNMDMKSLALE-SSVSSCSPRKV-ENKPLSDTLVSVT-ING
IVNMSLK-------------------Q-TSSQNIKKNVCDSDIKA------EADSNMQAG
AVNSASIDKTDIQ--AYFHPEDSEFASSSECA-QCTDYTNPVSAEPGFQTQEIPVVRMAS
LLKNIG--TELHEERMDLSAVALQSNPMS-AKDEQKIIHLPQDT-KCEVTELL-------
--------NGDF-S----QNA--HSCQNIVDFSK--S-EEPSASFVPTLA-DS-----VC
GNYKEHS---DPSMGHETK--ADAATLSRDTEISA----SASVCHGPHSGDSVQD-SL-D
CKN-CKFDTEN----LRGNHASQ-KNAVKDSCDSFTSL----NNSD-DTWTCSS--KISA
LETHISPRNQE--TEPCP-VSPNTKCMPRYIQIPDSHGIPKTYANFTITKEFKDTTRRL-
HSLKRHRNLSANCDLLSSWTSTWH-VADDLTQNTLDLEYLRFDHKLKQIIKK-GDSQQSS
PSNNIFPKESRMQFSVGTLPSTQTPEASGL-HLPPKNRSPILVTVVHSDTR---QQNHHH
RRSYSHSSLDS--AAAFWKEKCSQS--RN-LKNSE-RSQTVPFHLNKLKYNS--TFKESR
NDISLILNEYAEFNKVMMNSNQIVSQ-EKELNAA-SAEAV-SQE--TYQPRQSVSYRDVI
TDLCATLHVKLKGVMREACKSPFWFYLVETE-DKSFFLRTKSILKKGGHTEVELLDFCQA
FHRENE--TLLVIIKNEDMIAHLHQIPSLLKLKHFPSVIFAGVDSPEDILNDTYQELFRS
GGFVVSDDHVLESLSLVQLKEVLKTLEKLNE--NSRWKWLLHYRENKKLKEDVRVDSIAH
KKNLILKSYQSVNIIDLLHYHNCDSPSSTKAEILKCLLNLQIQHISARFAVFLTDKPAV-
-STEIFENHGILVTDVNYFTE---------NIQKIAAPFRSSYW----------------
-----------------------------------------

------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------MS
TKLFTDKKKQVTILRKNFK-----------TLTGFFC---LILKRRQNWYVSVDSVLAAV
LLPLWVIQP

PF12509 // ENSGT00530000063735_1_Domain_1 (250, 316)

KGKVKSVSENYTTNYTKPSSGYDCHVSENTNKVSNKTSHFRAFELSQYYFY
ELSGNTVIERPRQIC

ENSGT00530000063735_1_Linker_1_2 (316, 426)

PYVIVAFRYREPKTMAPPA-HKSILE--CSENVLMSPWKGKLIVQ
DRMLCDIALWSTYGAMIPTQLPQELDFKYVMKVSSLKKRLPEAAFRKQNYLERKVCFQDL
CFNLY

PF12480 // ENSGT00530000063735_1_Domain_2 (426, 522)

EVELSNRQGENIDKLTECIKNKQ--------------LAIIKCLEDRGFFILLTS
SALLSEPDF--GG-KQMGLHGLHLFHSP------LS-TGVK

ENSGT00530000063735_1_Linker_2_3 (522, 949)

DLKVE---DDISMKLIPIL
PALNCALLETKKSLPEERIHPNTLVK-HFQELYKVDRSPSLT-VAPQDRMKDPTFLGK--
-LPSGFDLIP-PAEKCPSESLTQLNSYFSDPSAYILEVSTALDLLAEHPQSPC-VSDGIC
DAGFSLVMTPDPDFPGSEAEVRKETETKKDSEEMLKAKKRVVVPLSP-ASNLRVQP-KRK
ASMPHVV---------------------Q-SKKVNLCHPFSKRTAPRADNSSDSPTTLKL
VKGQFPQKRKR-GAEVLTAQFVQKTKLDRKNQEAP--ISTDVPVPTNAKRARKQEKSPVK
TVPKAKPPVKKSPQKQRVNIVKGNENPRIRKQLQPVKGETASKLQSEISRDGQEDGISI-
NSVQPENTTVA-HNDLPENSIVNYDSQALNMLADLALSSATSS-TPVP

PF12509 // ENSGT00530000063735_1_Domain_3 (949, 1125)

EPRNL----HCS
SELPQN-DVLLS-KENSLRGTSDHEYHRGVKSQKGELLPNPSSD------RKSNSESDLI
VSQDEESLVPCSQ---------APAKAQSALTEEMLES---S--DASQSSSVSVEHSYAL
LLREHSKKNL--QEREIPSPVFPKNGTKSPEAVTPVGKVMPFRH

ENSGT00530000063735_1_Linker_3_4 (1125, 1287)

QPGLLLQQKPPDEPMV
KPKDRQASSRVKKSSC-SRIVFSCDDSVKITFKCETEYAFSLDSKYTNNPLEKTVVRALH
GPWNTDLPDNVEEVKLLLHMWVALFYSNQNKVIRSSRKVVEHSNPAKYVSINSTLESCEL
SEI-EECLGLERCS----ADPLLETN

PF12509 // ENSGT00530000063735_1_Domain_4 (1287, 1583)

EISRAHAAEVSFRDPNCLLPFIKTPLTQGLELCV
QNEQKKTFARKRH-PDTLENQDF-VCSYNNEPFQVIGEEARQESLDKLETSNLA-LSGIG
STRTNGPSVPNEEEIVQPLDSTRV-----------------ASYSGTVTQTTF-----TR
TYDGTGSQPV--------------------------------------------------
--------------------------------------------------------ICQS
------SVCSTLE-----NKVD

ENSGT00530000063735_1_Linker_4_5 (1583, 1664)

VPDAAMQT------KTGTLQDLIQHGSPKN-NECHPSL
ERK-DDNMECAMINPEPVTL----------------------I

PF12480 // ENSGT00530000063735_1_Domain_5 (1664, 1717)

FEKNAHVPLQT------
EAVNTADEPTTFNKELIKQVSPAASLRHPVSTSEKAQTQ-------GLRDISSLVVAGQK
GSKYLCASSVGRETLD-KEVCSLQKEMPL-PV-SLPSDKAMVMEALSLV-----KSSSYL
LPSEEVRCTQNFLSQTQSLLSLSSEGLVEPTQVEV-DSSSASTALG--KHCSLNCISSGC
HTSGDSLELRKNDKNGPNTENMNFEEFDSVFI-KQRRLSVSR-EVSLEL--SEEDSDIDL
ALTISPPTSPREEMPAGEIEQFEEA-PFSNLELQDVAEEIG-EPE-------EVAVTESR
EVNSADSVSVYPTVSEE-------------------------------------------
-PVENKERKGDNLQPVTVILSKENCTLEIAEEINVTSDFPF-DSVIEEVSPASSPEPPVP
VKETRPY-----QAVTPCILKLHGTQCEKSNRISQRVSEDLGVTE-------KENFFVG-
PTHPVGQDNFTQVQQMQVSAEMPLIL-TDHPGRTG--RPTL---PGKITEEIVSS-----
---------------------------------------EHDE-----GLSFSGKAQCY-
GRE-LN---------------------------QPAS-A---AEYTGDF---GPSPEK--
----LVKSGNPLQPIRVENRNLDLKHLVLE-SSEPPFSPRNVTENMALSDTLVSTAVPSG
I----VK-------------------QQTSPKSSQNNLLTSDLKT------DEGVYLQVK
SLTTASVDGAYST-QGCMCSVVPTLCSSSDSA-TLTHYVRPINAEPAFQAQEIPAVRMAS
LLKNGETEAELHKEITGLGTVGPQSNTKSSLKGERKAIHTLQDVSTCETKELL-------
--------NVGVSS----LCAS--PYQNTADTRENLS-KEPLASFVSESF-DTS----VC
GISTEHIEIENSGEGLRAQ--AGSETLGRDAEVSG----NSDMHYELLSGDSDLD-LLGD
CRN-AKCDLEDS-CTLRGSYTRKKEDVPTDGCESSLNF----RN-HQGDWGCSS--QVPG
MEMSLPPEHWT--TR----VKKEEKCVPPYVQIRDLHGILRTYANFSVTKELKDTMRTS-
HSLRRHPSFTANCDLPSSWTSTWQ-VADDLTQNTLDLEYLRFAHKLKQTIKN-GDSQHSA
SSANVFPKELPTQISIGAFPLTKISEASIL-HPASRSRSPLLVTVVESDPR---PQG-QP
RRGYPASNLEN---SSSWRERCSHN--RD-LTNSQ-RSQTVSFHLNKLKYNS--TLKESR
NDISLILSEYAEFNKVMKNSNQVVFQ-DKELNDA-SGEAT-AQVMYLPFPGRSISFEDII
IDLCTNLHIKLRSVVKEACKSTFLFYLVETE-DKSFFVRTKNLLRKGGHTEIEPQHFCQA
FHREDD--TLIIIIRNEDISSHLHQIPSLLKLKHFPSVIFAGVDSPGDVLDHTYQELFRA
GGFVITDDKILEAVTLVQLKEIIKILEKLNG--NGKWKWLLHYRENKKLKEDERVDSTAH
KKNIMLKSFQSANIIELLHYHQCDSRSSTKAEILKCLLNLQIQHIEARFAVFLTDKPTI-
-PREVFENSGILVTDVNNFIE---------NIEKVAAPFRTSYW----------------
-----------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------MATPV-HQIY-VLPSFLKVLISPWKGKLIIQ
GCMLCDITLWSIYGTVIPVQLPHDLDFKYVIKVSSLKKRIPEAAFRKQNYLEQKVCCEDL
CFNLY

PF12480 // ENSGT00530000063735_1_Domain_2 (426, 522)

EVELSNRQGEKIDKLTEYIKKEQ--------------LAIIRCLEDRGFFILLTS
SALVSEPDA--GE-EQVGLHGLHLFRSP------SS-ARVK

ENSGT00530000063735_1_Linker_2_3 (522, 949)

DLNVE---DDISMKVIPVL
PALNCALVEAKQSLHEEGTHPSTLVKHHFQELSKVDRSPALT-ASPQDGTKETAFLGK--
-LPCGFDLVP-PSEKCPLECLAQLKSYFSDPSGYILEVSTALDLLAERPQSPC-VSDGIC
DVGFSLVMTPDPELFDSEAEVRKETEKKNNSEEKLKAKKGVVVPSSP-VSNLRVQP-KRK
ASMPPMM---------------------Q-SKKMNLGRPFPKRTTPRADNGSDSPTTLKL
VKGLFPQKRKR-GAEVLTAQFVQKTKWDRKNQEAP--ISKDVPVATSPKRTRKQEKPLVK
TIPRAKPPVKKLPQQQRMNTVKGNQNSRIRKQPQPARGETASQLESEIISVGQEDAVSI-
NTVEPENTTVA-HKDLPGDSIVNYDSQALNMLADLALSSATSS-TPAP

PF12509 // ENSGT00530000063735_1_Domain_3 (949, 1126)

ESRNP----PSS
SELPQN-EVLLSPKENSLRSTSDHEYHRGIKSQKGGLLPKPCSN------KKGDSGSDFT
PSQDEEGLASCGQ---------APAKAQPALIEETLEP---S--DASQSSSVSVEHSYAL
LLAEHSKKHI--QQKAVLGPAFAKNGTRGPEAITPVGKVMPFRHQ

ENSGT00530000063735_1_Linker_3_4 (1126, 1289)

K-TSPLQKLSEE-LL
RRKTRWMSSRLKGFSR-SHTVLSCDGSFKVTFKCENEYAFDLDSRYTNNPLEKTVVRALH
GPWNTGLPENVEEVKLLLHMWVALFYSRQNKVIRSSRKVVEHSNPAKYVSINSTLESYEL
SEI-EESPSMESQS----TDPLLETSDV

PF12509 // ENSGT00530000063735_1_Domain_4 (1289, 1583)

SRGPATDVSFPDPDCLLPFTAPPPVRGLELCV
QNAQEERFTDKRR-QDSPESQHFIY-NCGNG---VIGETTKQESSDKLKTSHRV-LSGMR
SPHTNGPI-LGEEGTLQPLDSTIV-----------------TSYVDVITQATF-----TE
TCGKTSSQPV--------------------------------------------------
--------------------------------------------------------TGQK
------SVYSTLE-----NKVSVPHATMQT------KTGALQDPLQHSSPSD-NECQPSL
DRK-DDNRGCLMMNLEPVTP----------------------MPETNADVAVQT------
EAVNGADKPKTFNQELIKQESPATSPRHPISTLEKVPSQ-------GLKDSPPLTVAGQK
GTNCLCSSSVSRERLE-NEGCSLQNEMPP-PV-SSPPDKAAVMAALSLV-----RSSSYS
LPSEEVRHTQDVPLQTQSLVSVSSEERREPTQGEA-GSSPPSAALG--RKRSLPCTASRH
SISDGSLELRKNDKSGLKSENTNFESCNSVFI-EPVSLSANREEVSLEV--SEEDSDIDL
I-TVSPPPSPKEEMPAGKIEPLQEA-LVPRSELQDVAEEIG-EPE-------KATLAESG
ELTSADSVSVSPAMSEE-------------------------------------------
-PVENKEREGDNLQPVTLILSKESCTLEITEEINVTSDFPF-DSLIEEVSPASSPDTSVP
AEETQSS-----QAVSPCGSKLHGAPCEKSNRLSQLESGDVGTAE-------AELSFVG-
PACPVGQDHLTQVQQTRRSAEVPLPV-PHRPGREG--GLTL---PGQINEERVPG-----
---------------------------------------ERDK-----DLSFSEKVQHC-
SAE-EN---------------------------RSGS-T---AGYKGAS---APSLEK--
----LVASGNPLQPMSVENRNLDLKHLILE-SSEPPFSPRKIIENESRTDTLVSASAPSG
LVTASLK-------------------QQLSPRDIQINLCRGDVTA------HEGGRLPAK
STSTGSVGAACAA-QARGHSEVPALGSSSGSA-ALTHYMRPISVKPEFQTQEIPAVRMAS
LLKNSETKVESHEEAAGLSTTGPQSNTAFPPKGEQKATHTLPGISTYET-DLW-------
--------DVGAFS----AYAGLH--PNAAASRENLSKEEPSAAFAPEPF-DTS----VS
GFSTDQVDREDTRPELMTK--AGSETRGRDSGPGV--GMNSDMHYEPLSGDSDLD-LLGD
CSN-LKLDSEDS-YTLRGSHTRRKKTAAPDGYGLMMSL----HSSAREDWGCSS--WVPG
VDTGLLPRHCT--GG----VKKEDARVPCYVQIRDLHGVSRTYANFTVTKELKDTPRSV-
HSPRRHLSFTANRSLLNSWTGTQR-VADDLTQNTLDLEYLRFVYKLKQTLKN-GDCQHST
SSASVFPRESPIQVATEAFPLTKMSEAPFL-HPSSRSRSPLRVTVVHSDPR---QQN-QP
PRGHTSGSLDG--SCSFRKESCGHS--RD-LTDPH-RNQTASCHLHKLKYNS--TLKECR
SDISLILSEYAELGQAVMNSDQVVLQ-DKALSDA-SGEAT-PQAVCPPFPRQSASYEDMI
TDLCSSLHVKLKSVMKEACKSTFLFYLVETE-DRSFFVRTKNLLRKGGHTEVEPQRFCQA
LHRESH--TLVIIIRNEDIASRLHQIPSLLKLKRLPGVIFAGIDSPGDVLDHTYQELFCA
GGFVVSDDKILEALTLVQLKEIVKILEELNG--NGRWKWLLHYRENRKLRDDRRVDSTAH
KKNMILKSYQGANIIELLHYHQCDSRSSTKTEILKCLINLQIQHIDARFAVFLTDKPTV-
-SREIFENSGILVTDVNGFIE---------NIQEVAAPFRSSYW----------------
-----------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------MAAPT-SKIILEL--NKNALISPWKGQFIIQ
GCLLCDITLWSTYGTVVPLQLPRELDFKYVMDVSSLKESLPEAAFRRRSYLEQKVCCQDL
CFDLY

PF12480 // ENSGT00530000063735_1_Domain_2 (426, 522)

EVELTNKQGENIDKLMEYVKNKE--------------LALIKCLEDKSFFILFTS
SALTPEPGF--GA-EQMGLHGLHLFHAP------QT-AGAK

ENSGT00530000063735_1_Linker_2_3 (522, 949)

DLKVE---DGISLKVIPIL
PALSYALLEAKKSLSEEGIPPNILVKHSFQELYKVDKSLSLM-APPQDGVEDTASTGK--
-LSHAFDLPP-PLETCPSESLTHLKCYFSDPAGYTLDLSAALDLLAEHPQFPC-IADGVC
DAGFSLVMTPDPEFLDSEMEIRK-TETAEKSGRKLKVKKKAVTP----SSNQRVQP-KRK
ASTTAVT---------------------LPSKRVSLGRPTSKRTVPRTDNRS-CNPTLKL
VKGQFPQKRKR-GAEVLAAQIVQKTRLERKKQEA--SVSKDAPVPTNTKRAKKQEKSPGR
IASQPKPPMKKSPQKRKVNVARGRRNT--RKQLQPAEKEIALHLQSEISSDGQKDGLNL-
STSQQESISMI-PKGPPENSVISCDSQALNMLADLALSSAAAS-IPSC

PF12509 // ENSGT00530000063735_1_Domain_3 (949, 1130)

KPRNL----PCV
SDLPRN-NVLLT-KENPLLGASDHEYHKGVKSQKAVLLPKPYSD------EKISSESDLT
RSQE-ENLVPCAQ---------PLPIAQPAPHSEAREL---S--DASQNS-VVVEHSYAL
LLAEQSQKHL--HQRKLPSPAFVKNGIKGPEAGTPVGKVMPFRHLQNTSPLQKHSEDSLM
KHKSLFVSSTLKEFFC-SHTVLKCDGSFKITFKCEGEYVFSLDSKYTSNPLEKTVLRALH
GPWNTDLPENVDDVKLLLHIWVALFYSKNNKVIGSPRKVVEHKNPAKYVCINRSLESLDH
SEI-EAFSNVERPSVEGSVDPLLETKETHIGHATNMTFPGPNRVLPFINPPTTRDLELCV
QNDQKEVFTGECH-LDTSGNQNFIY-SCNTE---VTGGKTKQELSNKLETSNVV-LSGVV
SAQSHGTCIPSEDKTCQS---TKM-----------------VSYNDSVTQATL-----TT
AYDEASSELMCQKSVFDNLENKVDS-----------------------------------
------------------------------------------------------------
-----------------------FHPSPLI------KTDAVQDVIQHSSHIN-NECQPSV
EKR-EDNVECMMVNLDPVTL----------------------AFEKNASVPIHT------
-EVHTTDKPTGFNIELVKRVSPASSVQYPMSALEEVQTQ-------SSRDVPSLAMSEYK
DSKCLSASSVKKETPP-ESLCLLQKEIPP-LTSSA--DEGLIMEALSLV-----KSSSYS
LASDKTKCPQDDSLQTQNGLSMSLDEVLEPSKVNV-VS-STSVTLR--EQPSPNCIPAMS
DVAGASTVIMNSGSSSLNQEK-ILQTFSLVFP-KQTDLSLKREEVSMEL--SGEEADINL
TLTISPPTSPSEEIAAGEIEQFQKT-PVSNVGQQSRSEEMVEPEE-------EERLIRNR
EINSASCMSVYPVESRE-------------------------------------------
-LLK-------------------NCTPEVTEKVNVTLDFPF-GPLIE-VSPASSPDPIVQ
PGDRPSS---------PCCLKLHSSQSEKTNKFSQIKSGEVTIPE-------KESLFLG-
PESPKGQDKLAEVQ-VQISAEMLQIT--TNAEVEG--RVNM---PGKVTKVSVPS-----
---------------------------------------EHSE-----NLSFLEKVQCN-
-T-ELN---------------------------ELSL-P---AKYGGNF---K-PLEK--
-------SGNSLEAGCMENRNVDVKHLALE-SSVPSCSPRKVVENKSLTDTLVSIT-TSG
IVNMSLK-------------------Q-TSSKNIKKNVCDSDVKTDSDVKTEADSNMQTE
AVNSALIDKTDVQ--AYSHPEVSKFVSSSDSA-QCTYHAKPVSVEPGFQTQEIPVVRMAS
LLKNIG--VELHEEKMDLSATGLQSNSMS-AKDEQKTMHVLQDT-ICEVKEFL-------
--------NGDVFS----QNAH--SCQNTVDFSKSIS-EEPSASFVPEFV-DA-----IC
GVYKEHTFNESPNMVHETK--ADAETLSRNTEISV----NASMFCGPRSGAYVQD-SH-D
CKS-CKFDVEN----LRGNHESQ-KDAVKDSCDSFTSL----NNSD-DTWACSS--KIST
LETHIPPRDQE--TEPRL-ISPN-KCIPRYIQIPDSHGIPKTYANFTITKEFKDTTRRL-
HSLKRHRNLSANCNLLSSWTSTWH-VTDDLTQHTLDLEYLRFDHKLKQIKK--GGSQQ--
---SSFPKESLVQISSGTSPSTQTSEASGL-HLPPESRSPILVTVVRADTR---QQS-HH
RRGCSPSSLDG--SSSFWKKKCSQS--RN-LKNSE-RSQTVPFHLNKLKYNS--TLKESR
NDISLILNEYAEFNKIMMNSKQIVSQ-DEELNVA-SAEAV-FQE--AYQPRQPVSYEDVI
TDLCATLHVKLKGVVREACKSPFWFYLVETE-DKSFLLRTKSILKKGGHIEIELLDFCQA
FHRENE--TLLVIIKNEDIISHLHQIPSLLKLKHFPSVVFAGVDSPEDIVNETYQELFRS
GGFVVSDDVILESLTLVQLKEILKILEKLNE--NGKWKWLLHYRESKNLKEDVRVDSIAH
KKNLILKSYQSVNIIDLLHYHNCDSPSSTKAEIFKCLLNLQIQHISARFAVFLTDKPTV-
-STEIFENNGILVTDVNYFTE---------NIQKIAAPFRSSYW----------------
-----------------------------------------