ENSGT00530000063634 : Linker Region Query Results

----------------MPRLLRDVLCVIETFHKYAREDGD-EVTLTCRELKRLIQGEFED
ILQPRV------------IHAVERNLNLLTIDSDGTIAFD-----------E-FVL-T--
-I---------------F-N-L-L-N-L-H-YLD----IQS-----LLN---S-EPRQ--
-GSKP-EE-KPDD------MNLQATS---RT---------GQPTEA---TPPA-------
-----------QDKL----------------VLPL----------------------GIV
SSAQLSPEER----------------G---HNRVE-PQGDTKTHKLPGETSGHNDP----
---KNQHL-------------------------------------------------EGD
-------GQSQEVTQGVASTGDKGAE-NETNK---PTAGSEQKGSPTKGEEG-QDKEIPK
EED-KP----AREQSDT------KTRDQI---------------GEQEENLG--------
--------------------------------------------TQSSPSEETTQRLPE-
-----------------DQ----------RVAAEK-VVKE----------HSHAQEQPL-
------Q------------------GKDK-L-------------SSEDT---DLP-----
EQ--------T-------DSKDD--RRT----AETQEPGNNAD------------RTPLE
------------TKN--AAEPEGDGR---------------------TPETQEPPAQE--
------------------------------------------------------------
------------------------------------------------------------
------------------KEHETNNLSVHDDSRNV----SGTPDVR--------TEKKEG
RGPEAHEIVGR-EE--------------------SKR---------------------KS
QPPAL-------------EEEEEEAQD--GKYPGWE------LQERDAGEGSKT------
-----------------------------------------QELSSEGGDQN-----HPE
I--------------E-------AA----V-TPGEEARHAEEGTAEALVSSKNAPTA---
-GARE----------RIGE-----------------------------------------
--------------------------------------------LSPLEN-KSGGENKRV
TKTQDK--LVKEEDGSQ-----------------------------------GEDQEPTV
TQTDKGSSETPNSLTPEDGDSSSETS---------------D------------------
--------PPMQGDPQ------------------SQVDSHEESV---------QGSHNNN
PDT---------------------------------------------------------
------------------------------------------------------------
---------------------------------------------QKQVALGEKNRTQEA
V----------------------------------------G------------------
-GEDEQLTEEQEPPEGKEHK-I--------QGSG-----T-KGPGPAVEPSEPPEAQ---
---THLET----------------------------------------------------
------------------------------------------------------------
---------E-------KLLTLEEEDKSPQELAGEQ-------------NPVPESGLEEK
TQRNEGSYSAESSTVYSSPLYKYLQE-ILQQTDITKE--------------------EHQ
N---------------------------------QADSQGIS------------L----C
SHQLSNEISDFPIFSNN--------------------RYTRELLPGKDSADAQQTSAPQA
LEDEQGHPQREEQDHKAVRATT----------------------------------K---
-----------------------------E------------------------------
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----------------MSPLLRSIFDITEIFNQYASHDCD-GAALSKNDLKNLLEREFGT
VLQRPHD-----------PETVETVLELLDRDTNGHVDFS-----------E-F-L-L-F
-V---------------F-K-V-A-Q-A-C-Y--Y-A-L-G-Q-A-AE--L-D------E
E-KRV-H-G-E-R-R-R-DL-S--PD-RRQ-ED-Q-R-----------------------
-------------------------------KF-------------------------ET
RDRQVDEEPG-----RRRWQKRQE----PES--AE-GD----QRKKLE-RSEQRSS----
-------------QPRD---------DEEQRL------------------ATFSRWLKL-
----------------------------VITL-------------------SRQAEEQLE
EE-QLR----RQERDR-----------RFREE---QE---LRQEREEEQ-LRRQ------
-------------E---------------------RDRKFHREQELDQERVEEQLHP---
-----------------------------QKRDRK-FREE-------------Q--ELR-
------Q--ER-EEEQL--------RRQERD-----------------R---RFREEQEL
HQEREEE--QLR---RQERDRKFHRKQE-LD-----------------------------
------------------------------------------QE----------------
--------------RVEEQLHPQ-----KR-DRKFREEEQLRRE--------RE------
--------EE---QLRREEQQL-R--RREREQQLRQERDRRF--REEQLRQERKEE--QL
RRQEQQGHY--Q-----------AEGPF--------VREKSS---QE---------QELR
QEEQR--------S--RV----ERE------R-KFQG----------------------E
QL-R--RQEEEQRRSQVRERQSQDEKG-DMETGKRQFAHVPVVRS-------------SP
L--YEY-I-------------Q---EQRSQFRP---------------------------
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----------------MPQLLNSILNVIEVFQKYAKENGD-CASLSKEELKQLLLAEFGD
ILRRPND-----------PESVETIMNLLDRDRNGHVDFH-----------E-YLL-L--
-V---------------F-Q-L-V-Q-A-C-HHK----LGN---K-PCG---D-------
RTSR-REREQE-G-----TQDHKFPGN-TGR---QH----RQRHEEERQ-----------
-DSHYS-QSERQ---------------GQDSH--------------------------HG
QSERQGQDS--HY-SQSERQGQESHYGQSERQGQD---SRRGQSERQGQESRCGQSERQG
QESR------------------------YGQSERQGQDSC--------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------YDQSERQD
EDSIFDQSERQGQNSSSDKRLN--------------------------------------
----------------------------------SYSSQTNQQESGSYY---GWSGRMGQ
ESGCGQREGQG---LGSHYGQTDRQG-Q--S------S-----------HYDQTDRQGLS
-------------------C--QYG-------------------------------QT--
---DR----QGQSSQYGQTDRQG--------------------------------LSCQY
GQTDRQGQSCRYGQTDRQDQ----------------------------------------
-----SSQYDH-------------------------------TDRQGLSSHC-G--QT--
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-------------------------------------DRQGQSFHYGQTDRQGQSSQYGP
TDR-QGLSCQYGQTDRQGQSCQYGQTDR--------------------------------
----------------QGLS-----------------YQYGQTDRQGQSSHYGQTDRQGQ
GSYY--GQTDRQDLSCRYGQTDRQGQSSHYGQTDRQGQSSYYGQTDRQGQSS--------
----------HYGQSQTGEI------------EIQRQNRYSQGTEG-TR-----------
--R-DSYVEQSGRSGRLSQQTSRQEVY-QNQGQGFQSR----NSHQVWEP----EEDSQ-
-----------HHQHKLLALI--QQEKP--LCHKERAGQSCSS-----------------
-------------------EQGHRQAQTRQSQSE--------------------------
------------------------------------------------------------
--------------------------R---------------------------------
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----QSHGA------EEEQSRQ-----------------SWSRHSRGGLESPWETQDRR-
----------DRQTHEDEQNHQ--------------------------------------
--RR--------------------------------------------------------
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----------------MSQLLKSIVTVIDVFYNYCGQDEE-CDTLCKKELKELLNKEMGP
LLKNPNN-----------PDTVDVFMQILDRDHDRRVDFT-----------E-YLL-M--
-V---------------F-K-L-T-M-A-C-NKS----VVN---E-YCH---A-------
SGSKQKHQGRH----------HQESQNKSEEE---------E-------VSTE-----QE
SDSSHSSWSSR-EGYGSS--RSGHSYRTKSHRQGS-----------------------G-
-SPGGERND------------------------SSYHVGHGEGSR-RSHHRSSS------
---------------------------SHSGS--------------SSGSKANKQVGRRH
K--------------------------TSIS-------------PSRK----SG-----G
EEYEYG-------------------TSH--------------------------------
-------------------------------------------SSREESR----GFS---
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----------------MSVLLQSIVNIIDIFYQYAEDDGE-CETLSKKEMKELLEKELSS
IMSNPKD-----------PQIIEAIFHILDQDHDDKVNFA-----------E-FLL-M--
-V---------------F-K-L-A-M-S-F-NKS----VSK---E-YCE---A-------
SGSKHKSQDHH----------HKEEKSVTEEE--------ED-------ETGS-----DT
D---------A-EEQQCS---FGHSQKKGKYRNQS-----------------------RS
NSPW-KRRRSSS-----------------------SNSEHKKDSR-KRHHKSRK------
----------------------------------------N--EKEKNGLS--SK-----
----------------------------------------------------KN------
---GRR-------------------YKSST------------------------------
----------------------------------------HEK-HGS--TGRGRELKDSS
GESRLGE----QK-TSSK-----------EKKKGN-------------------------
---------QRSRQG----QAEDTSAHLGSGKGKSKDRSKTRRQTSSHH---S------S
SENKGQS---T----------------------------------ERSSHSGSGHQQSSS
------------SQG-HRGS----------------------------------------
---------------------------------------SQRGRQQSTS-----------
------------------------------------------------------------
--SQVSDSEGST-----------REHT--------------------------------R
ESVSG--------H--RQESVSGHR------Q-SSSP-----------------------
---------------------------------------S----S---------------
-------GS-SS----SRRQGS---SH---------------GSSS--HRQ---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------GQQ-----
-----------SDRSSH-SGSGHQQSSSSQRQHGSSQRGRQQSTSSQ-VSDREGSTR--E
HTRESVSGHRQSSSPSSGSSSSRRQG-----------SSHGSSSHRQGQQS---------
T---DRSSH-----------S---------------------------------------
------------------GSGHQ---Q----------S------SSSQGH-RG-------
----------SS-QR-------GRQQSTS-------------------------------
SQVSDSE--GS-------------------------------------------------
----------------------------------------------T---R---------
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-----------E----HTR-ESVSGHRQSSSPSSGSSS----------------------
-----------SRRQG--------------------------------------------
------S----------------------SH--GSSSHRQRQQSDRSSH-----------
-------------SGSGHQQS---------------------------------------
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----------------MTYLLRSVVTIIDIFYKYTKQDEE-CGTLSKNELKELLEKEFRP
ILKNPDD-----------PDTVDVIMHMLDRDHDRRLDFT-----------E-FIL-M--
-V---------------F-K-L-A-L-A-C-NKV----LGK---E-YCK---A-------
SGSKKHRRGHQ----------QQEEESETGEE--------E--------ETPR-----QK
SGFKYSRWNEG-EEHGHS---SGGSWGRAKYRRG--------------------------
------------------------------------------------------------
-------------------------------------------------SNS-RKVERQD
E--------------------------LSSL---------------------EQ------
---S----------------------RNHG------------------------------
----------------------------------------FIS-GHSWSSNKENHGSKS-
--EERGE----KR----------------DKSHGSPSR----------------ESGEDY
------------------------------------------------------------
--------------------------------------ESGSR--LNHQGR---------
-------------KD-HSELL---------------------------------------
-----------HGLEKNKH-----------------------------------------
--ESNYTQSREG------------------------------------------------
--------------------------V--------------------------------E
QKL---------------------------------------------------------
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-------G----------------------------------------------------
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----------------MTQLLNSIITIIKVFHEYAEMNDD-CTSLCKKELKHLLLEEFKE
ILRRPDD-----------PETVDNILQLLDRDHDEHVDFN-----------E-FLL-L--
-V---------------F-K-L-V-Q-S-C-YQI----QSK---K-SCR---D-------
RSGTHQERGRE----------RTRDHHLPEEG--VSRQQ-KQRHRGQRQDTPCDQSEGQD
KDSRYGQYGRQDEDSRYG---QYG--------RQD-----------------------E-
DSRY-G----------QYG-RQDQ----RS--------HHDQSER-QDQHSHHG------
---------------------------QSGKQDQHSHHGQS--EKQDQHSHQ-SQSGKQD
K--------------------------TSNC---------------------GQ------
---SER-------------------LGQDS------------------------------
----------------------------------------HHS-------NSNR------
-----------------------------------------------------QGEDTC-
------------------------SGQSGRV---------------------------RQ
ESSCGQS---ER---QRYVSYLGQHRRQSQSFGCS-EPEQQ----YNDSHCGQSQSLGQD
-----------STCG-QTGRQRQESHS--------------------GQSRR--------
---------QRLDTQYGQ-----------------------SGRQGLDS--QYD------
-QSEEFGQGTSCGQTDR--------------QGLD-SQCG-QSRK-YE------------
-GFEQGSNYGQT-----------NRQG---------------------------------
-----------------LNSGYGHS------E-M--------------------------
------------------------------------------------------------
-------QG-QN----YQFQNN---R---------------------TGQE---------
------------------------------------------------------------
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------------------------------------------------------------
----------------------------------------------------GQGLSRS-
----QGYLSGEGRQSHF--------------QQGLWQPER--------------------
-----------------ESER---------------------------Y-----------
-------QH-----------K------------------V--------------------
----------------YSLSQQE---T----------S------LCHKGRDWQ-------
----------QC-GS--------------------H-----QTG---------GQAQ---
----D-------AQRHEERQS---H-------Q---------RYHQQTHE----------
--------------------------------EEE-----DCQ---T---RDRQSQE---
--------Q--QGT--------------------SSQRQDRQT--HEQQQSRQRYYQQTH
-------------------EEEDRQTQDRQGHEEQGTA--------QQ------------
------------------------------------------------------------
-----------------------RD-----------------------------------
------------------------RQAYGNE------QSHQS------------------
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----------------MPQLLQNIHGIIEAFGCYARSEGG-CKVLTRGELKRLLEHEFAD
VIVNPHD-----------PSTVDEVLRLLDEDNTGAVEFK-----------E-FLV-L--
-V---------------F-K-V-A-R-A-C-FKT----LSESP-TGACV---S-----DR
SESC-----HP-G----SGKELEQ-GQRGGTGV--GRDGAEQNCED--------------
-------SS-------------------------------------------------RG
QRDQG-----------SKEQVR---------------VGTHTQN----------------
------------------------QDSYPAQISSHNT------------------EAESQ
RQERIVNQQTQATRQVEQTPRTEDKTW--TRE------R--------------R-----S
ERQA-----QVSQQ-----TEETT-VGTT-------------------------------
--------------------------------------------TQTQE--G--------
--------AFQTQGFNCGQDRGT----------------S--------------------
-----SHSQDRILEDQ------DATEHYQTQ-------------AESHTQIRTQTVEQSC
RQQTRGGSIQTH---RSTYDQNRQTE-----------------------------IHSQD
RNQ---------------SGQADID-----------------------------------
-------HHQ--AQSY--------------------------------------------
------------------------------------------------------------
------------T-----------------------------------------------
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---QTHTQMREQSRSQ----------------QEGNSHIQTHGSIHDQNRMTEIYGQDSS
H---------------TGQVGT----G--HF----------QTQVGSYSQTL--------
-----------------------------------------E------------------
------------------------------------------------------------
----------------------HDGNQSERQIRAPE------------------------
---------------------------------------------------KRRIQ----
IQPGMGQGWTPVSNCET-EE----------------------------------------
---------SVLG-------------------------GQVQTETGT------VMESHP-
-GR----------KGGQG-----------------------KSTPT--------------
-------VIRDEWVNDHTREI---VIRSQDPGS----LHA--------------------
------------------RASSAQGQDTAQ------------IQGEKKGVP-AKG-----
----------L--------------------------YSYLKTDQP--------------
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-------------

----------------MAQLLSSILSVIEVFHKYAKENGD-CTLLCKEELKQLLLAEFGD
ILQRPND-----------PETVETILNLLDQDRDGHVDFH-----------E-YLL-L--
-V---------------F-Q-L-V-Q-A-C-YRK----LDN---K-SYG---G-------
RTSQ-QERGQE-R-----AQDHKFPGN-TGT---QH----RQRHKEERQ-----------
-NSHHS-QPKRQDRD---------------SH--------------------------HS
QPERQDRDS--HH-GQPGRQDRDSHHGQP---------------ERQDRDSHHNQSERQD
KDFSFDQSERQ------------SQDSSSG------SGKK---VSHK--STR--GQTKWQ
G--HI-------F-------------ALNGCE------KP------VQ-----------D
SHYGQ-------------------------------------------------------
---------------AE---------------------------RLAQ-Q----------
------------------------------------------------------------
----------------------C-----ETFGQDSRFNQTNQQKSGSYC---GQSGRLGQ
ELGCGQTDRQD---QRYHYGQTDRQD-Q--S------S-----------HYGQMDRQGQS
-------------------S--HYN-------------------------------QK--
-------------------DRQG-------------------------------------
------------------------------------------------------------
-----------------------------------------------QSSH---------
------YGQTNRQG---QCYHYGQTDRQGQSSHY-SQPDRQGQSFHYGQ---T---D-R-
---------------------------------------QGQSSHYGQPDR---------
------QGQSSH----Y-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------GQTDRQNQSSHYSQPDRQGQSSHYGQ
TDR-QGQSF------------HYSQTDR--------------------------------
----------------QGQS-----------------SHYGQTDRQGQSSHYGQPDRQSQ
SSHY--GQTNRQGQSSHYGQTDRQSQSSHYGQTDRQDQSSHYGQMDRQGQNE--------
----------QNHQRR--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------DRQT
HEDEQNHQRRDRQTHEDEQNHQ--------------------------------------
--RRDRQTHEDGQNS-Q-------------------------R-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-------------

----------------MPQLLRNINGIIEAFRRYARTEGD-CAVLTRGELKRLLEQELAD
VIVKPHD-----------PATVDEVLRLLDEDDTGTVEFK-----------E-FLV-L--
-V---------------F-K-V-A-Q-A-C-FRT----LSESP-EGACG---S-----QE
SGSR-----VS-A----ASQDLGG-GQRSSTSV--GRVGRGQDHAG--------------
-------SG-------------------------------------------------SA
QSEQA-----------SRGQGG---------------PGPQTQG----------------
------------------------QDISAAQVSHQDN------------------QSESQ
RQEGT-SQLTQARGHVEQPQRVCKDRSPQTRE------R--------------D-----E
EGQP-----QTREQDRAPQTSGTV-TGTR-------------------------------
--------------------------------------------TQT-Q--THTQTEEQD
RSHQTGSTSVQPQESTYGQTRET----------------E--------------------
-----IHGQDGSQTSQ-----VGTGGHIQTQ-------------AGSQT----QTVEQDR
SHQTGSASIQPQ---EPTYGQTRGTE-----------------------------IHSQD
RGQ---------------TSQVVTGG----------------------------------
-------HVQTQAGSQTQTHTQI--------------AEQDSSL--------------QT
GSASIQPQEPTYGQTRGTET----------------------------HSQYRSQTSQVV
TGGHVQTQRSVTQIVEQNRSHQTGHATIQAQEFASGQTRGTVT--NGQDRS---------
-------QTNQ------VVIG-GHF-----------------------------------
QTQEGGTQTVEQGSSH----------------QTGSASIQPQEPTCGQTRGTETHSQDRS
Q---------------TSQVVT---GG--YV----------QTQGIT-GT-V--------
-----------------------------------------E------------------
------------------------------------------------------------
----------------------QESSQTAGHTGARD------------------------
---------------------------------------------------QGQTE----
RQSDSGQRQTQESSNAA-GE----------------------------------------
---------TVLG-------------------------GQAQTGASTPTGRQDGCSTHPT
CRV----------TGGQG-----------------------ESEPT--------------
------TEVKQEWVDDLAGET---VIPRQDQGS----LHT--------------------
------------------RVPSAQGGEAAQ------------PE-GNRGLT-ARG-----
----------L--------------------------YSYFRSGKL--------------
------------------------------------------------------------
------------------------------------------------------------
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-------------

----------------MPRLLRDVLCVIGTFHKYASEDSN-QTTLTGRELKQLLQGEFGD
FLQPCV------------LHAVEKNLNLLNIDSNYIISFD-----------E-FVL-A--
-I---------------F-N-L-L-N-L-C-YLD----IQS-----LLS---S-ELRQ--
-VTKP-EKEKPDD------VDLQTAT---GD---------GQWTAG---TSPT-------
-----------QEER----------------MLPS----------------------GMA
SSSQLMPEES----------------GAVGNNRVD-PWREPKTHNFPGEASEYNDP----
---KNQHL-------------------------------------------------EGD
-------EQSQEVAQDVPTTENNEGQ-LKTKK---PMEGSKQTSSPTE-RKG-QDKEIPR
ERD-EP----AREKSVS------KIRDQF---------------GEQEGNSG--------
--------------------------------------------TQSSPAQEATQRPSE-
-----------------DQ----------KVRIEK-E--K----------HSNTQEPSL-
------Q------------------GEDE-P-------------NSEHA---DMP-----
EQAAARKPSQTQ---KSTDPEDV--CRT----FDNQEPGKGAD------------QTPAE
------------TKK--SGETEDYGR---------------------TSEFQE-------
------------------------------------------------------------
------------------------------------------------------------
------------------KECETRDLQDQGGCRNR----SESSDMR--------DERKER
RGPETHGTAGQ-KE--------------------HDR---------------------KT
QPLVL-------------ETQTQDGKY--QELQGLS-------KSKDAEKGSET------
-----------------------------------------QYLSSE-GDQT-----HPE
L--------------K-------GA----A-VSGEEAEHTEEGTAEAFVNSKNAPAAEGT
LEAKE----------KTRD-----------------------------------------
--------------------------------------------LAPLEK-QSAGENSRV
TKTHDK--PVEEEDGYQ-----------------------------------REDPESPI
TQNDKGSSETPNSLVSEEGNSSSKTG---------------E------------------
--------LPNQGDSQ------------------SQGYSHGESA---------QGGHDNN
SGT---------------------------------------------------------
------------------------------------------------------------
---------------------------------------------QRQGTPGEKNRAQEA
V------VLAVR------------------------------------------------
-GEDIQLTEDQEQPAREKRK-S--------QGSG-----T-KGPGAAVEPNGHPEAQ---
---ESTTRD--ENRKSLEIEITGALDED--FTDQLSLMQLPGKGE---------------
-------------------SRNKLKIQGPSSKEKKGRAPEAQDTLLKRLDEDNSASP---
--QIQLETEE-------PVTL-EEEDESPQELAGEGDNQQRPTKE-EHNSSVSWSSLKKQ
MQRDQEPCSVEKSTVHSSPLYQYLRQKILQETNINQE--------------------EHQ
K---------------------------------QVQIAQASGPG---------LCS---
-VSLTSEISDCSVFFNYSQASQ---------------PYTRGLPLDESPTGTQETPAPQA
LEVKQGHPQRERLVPQREASTT----------------------------------K---
-----------------------------Q------------------------------
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-------------

----------------MSQLLNSIITVIKVFHEYANTNGD-CTSLCKIELKQLLLEEFKD
VLR RPHD-----------PD TVDTILQLLDRDRDEHVDFN-----------E-FLL-L--
-V---------------F-K-L-A-Q-S-C-YQI----QSK---K-LCR---D-------
RG--PQERGRE-R-----TQDHHLPEEVRGE---QQ----KQKKKEQRQ-----------
-DSRYRQYEGEDEEDSRC--GQ-NEGEDENSH--------------------------DG
PSERQDQHS--HR-DQSGRQDQHSHRDRSERQDQH---SHRDQSGRQDQHSHRDRSGRQD
QHSHRDQSGRQDKHSHRDQSEEQDQHSQQGQSERH-------------------------
------------------------------------------------------------
--SLQS-----------------ERLGQDS------------HRRN-SKRQG--------
--------QDIL---------------------------SGQSGRMRQ-ESSCDQSEKQK
HISYLSQNKRQSQGFDYS------------------------------------------
--------------------------------------EPEEQHNGSYY---GQSQRLGQ
DSSCGQSDRQRL---NTGNCYSGRQR-Q--E------Y-----------YYGHSGRQ---
------------------------------------------------------------
----------GLDSSYGQSERSE--------------------------------QETSC
GQTGRQRLDSHYGQ----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------SGRQGLDTQYGHSER---------
------------------------QGLDTQ-----YGQSGRQGLDTQYGQSGRQGLDTQ-
------------------------------------------------------------
------------------------------------------------------------
-------------------YGQSGRQGLD-------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------TQYGQSGRQGLDTQYGQSGRQGLNTQYGQSGRQGLDTQYGQ
SGR-QGLDTQYDHSGRQGLDTQYGQSGR--------------------------------
----------------QGLD-----------------TQYDHSGRQGLATQYGHSGRQGL
ATQY--GQSGRQGLDTQYDQSGRQGLDCHYGQSGRQGLDSHNGQYEGFGQDS--------
----------SYDQTDRQGLDSDYGYS-----ETQGQNRHFQDSRR-EG-----------
--Q------------------EGQRLN-RNQGYLSGADQQDHFQQGLWQP----ERESE-
-----------HRQHKLYSQS--QQERS--LCHKGRDWQQSGS-----------------
-------------------QQIGRQSQDRRRNEE--------------------------
------------------------------------------------------------
--------------------------K---------------------------------
------------------------------------------------------------
----QSHQR------EEENSQQ-----------------ARDRQGHEEQGTSSQRRDRQT
HGEKQSRQRYHKQTYEEEQDHQ--------------------------------------
--RRDRQTYGNEHSYQS---------------------QGSQTQNRQTQDNERYHQTQDR
Q-----------------------------------------------------------
------------------------------------------------------------
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-------------

----------------MSPLIRSIVDITEVFNQYASQSCD-GASLSKKDLKNLLERELGD
VLQRPHD-----------PETVDLTLELLDRDCNGRVDFN-----------E-F-L-L-F
-L---------------F-K-I-A-Q-A-C-Y--Y-A-L-D-Q-A-AA--E-L------G
E-KRA-L-P-R-E-K-R-NL-S--QD-RRQ-ED-Q-R-----------------------
-------------------------------RF-------------------------EP
RGRQLDEEPG-----RRSWQKRRE----QEE--RA-----LE----------QRHR----
-------------QHRD----------EEQ-R------------------LQRRELQELE
E--R------------------------------------LAEKEPLSWSKGRDAEEFSE
VEELQR----QERQE-------LKGRGQTEER----------------------------
--------------------------------------RLQKR------RQEE-------
------------------------------------L--R-------------E--PLL-
-----R------------------------------------------------------
------------------------------------------------------------
--------------------------REQELRREQEL-----------------------
-----------------------------------------RRE--------QELR----
---QELRREQ---ELRREQ---------ELRQELRREQELNRRQELRREQELRREQ--EL
RREQEL-------------------------------------------------RQELR
REQE--------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
LRQELRREQELRREQE----------------------LRQE------LRREQELRREQ-
------------------------------------------------------------
------------------------ELRQELR-----------------------------
-----------------RE------------------------QELRREQELRQELA---
---------------EE--D---ELT---------------RI-----READESITQRWQ
WQLENE-------------------------------AEARQNK---VYSR---------
PRR-QEQR-----LRQELEEHQLR------------------------------------
------------------------------------------------------------
-------------------EQEEQRRDLQQQRPAEE-----ASQRN--------------
-------------QWERPQRAEER----------LEQEQRFRDREEQR------------
------FR--EEKLQRAELQDS------LLE--EEQRRVQEERREPNRSRQ--LREES--
-----------QRRHTLYA-------KP------SQRQRREEELR-EEQL-----LQEE-
--------------------QRQQR--ERKYRR---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------EEDLQQEE------------------------------------
-------------------------ERLQQDEEQ--------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------IQRERRRLQRERQYQEEDLQQEEER
LQQ-------------------------------EEERLQ---RE------RRRLQQERQ
Y------------------------------------QEEDLQRLRDEDERRDLKW----
QWQPRKENEVRSNRLFTKRREDEETTQQLED-PQER--ERRQDRRPLQDEEE-----EKR
ELEQERRRRQQRDRQILEEEQ----FQREH---QREAKRRDEKFQEEEQLQGE-SR---R
QQQEREGKFLEEERQLRTEQE-----------------------EQRRRQEQEREFQVE-
EER---------------------------------LQEREKELRQECDRKSREEQERRQ
QRE------------------EEQLRRQEQDQRFRREQERRLERE-----EEQLRDRPFR
RDQERRLEREEEQLRDRPFRREQERRLEREEEQLX--------------------XXXXX
XXXXXXXXX----XXXXXXXXXXXXXXXXXXXX-------------XXXXX-----XXXX
XXXXXXXXXXXXXXX-------X--------XXXXXXXXXXXXXX-----XXX-XXXAAW
SV--------R-KSS-CGID--------------H--SAGNKSA----AWSVRKSSCGTD
------HS--AGNKS-S-----DAK----ENS----VRKKSA------------------
-ARNWRKSSV--------------------------------------------------
-----------------------AKSET-----ELEEERLRDRKIRREQELRRDRKFHEE
EERRQEEFE-----EKQPRLQEPDRRFRREQELRQEREKE--Q--R--------------
------------------------------RGQERDRRSREEQELRQELEEER-----L-
------------------------------------------------------------
-RDR-------KIRQELQEEELRRQERDRKFREEQELRQELEEERLRDGKIRR---EQEL
RREQELS-------------------------REQ------------------------E
LRRER----EEERLRDRKIRRDQELRQEL--EEEQLRRQERD------------------
-------------RKIREEQELGQELEEERLRDRKIRREQELRRE------REQEQRRRL
EREEEQQRLQEREEEQRRRQERE-QEQQRRQEREDEQFR--FEEQQRRRQEREQQLRQER
DRRVLEEEELRQEREE---LLHRQVGG-RKFREEERLRLEREE-------QQRRLQERDN
RRFREEVELRQEREEQQLRQ---ERDRKFREVEELRQ-----------------------
---------EEEQRRRQERDRKFREEKHLR-----EEQQL----RREKRDGQYPTEE---
-----------QFARDTIRRQ-EQELRQEEEQRRRQERERKFQEEQ-IRR----------
-----------------------------RQEEQRRRQILE-----PGTRQFANVPV---
-------------------RSSPLYEYIQEQRSQYRS-----------------------
------------------------------------------------------------
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-------------

----------------MPQLLRNINGIIDAFRRYARTEGT-CTALTRGELKRLLEQEFAD
VIVKPHD-----------PTTVDEVLRLLDEDHTGTVEFK-----------E-FLV-L--
-V---------------F-K-V-A-Q-A-C-FKT----LSESP-EGACS---S-----QG
SGRL-----HP-G----ASQELGE-GQRSGTEV--GRAGKGQRCEG--------------
-------SS-------------------------------------------------QG
QCEQT-----------SRGQNR---------------PGAQTQG----------------
------------------------AATVSVWVSSHDR------------------QAEFQ
SQERT-SPQTQLWEHTQQIQAVGEGQSLQTRE------M--------------R-----P
ERQP-----QTRERDRACQTGEIV-TGSG-------------------------------
--------------------------------------------TQTKA--GATQTLDQG
SSHQIGGTNTQTQES---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------TSGQNRETETHGQGRS
Q---------------TSQAVT---GG--HA----------QTQAGSHTQTV--------
-----------------------------------------E------------------
------------------------------------------------------------
----------------------QDRSQTVSHGGTRE------------------------
---------------------------------------------------QGQTQ----
TESGSGQRWTPVSKPET-GE----------------------------------------
---------TVPE-------------------------GQAQTGASTASGRQDWSSP---
-SV----------TERQG-----------------------DRQPA--------------
-------VVVEEWVDDHSRET---AILRPDHGS----LHP--------------------
------------------SVSSAQGQDAAQ------------PE-EKQGIT-ARE-----
----------L--------------------------YSYLRSNQP--------------
------------------------------------------------------------
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-------------

----------------MAQLLNSILSVIEVFHKYAKGNAD-CALLCKEELKQLLLAEFGD
ILRRPND-----------PETVETILNLLDQDRDGHVDFH-----------E-YLL-L--
-V---------------F-Q-L-V-Q-A-C-YHK----LDN---K-SYG---G-------
RTSQ-QERGQK-G-----AQDRKFPGN-TGR---QH----RQRHEEERQ-----------
-NSHHS-QPERQDGD---------------SH--------------------------RS
QPER------------------------------------------QDRDSHHNQSERLD
KDFSFDQSERQ------------SQDSS--------SGKK---VSHK--STS--GQAKWQ
G--HI-------F-------------ALNRCE------KP------VQ-----------G
SHYGQ-------------------------------------------------------
---------------SE---------------------------RLAQ-Q----------
------------------------------------------------------------
----------------------S-----ETLGQASRFNHTNQQKSGSYC---GQSERLGQ
ELGCGQTDRQG---QSSHYGQTDRQD-Q--S------Y-----------HYGQTDRQGQS
-------------------S--HY------------------------------------
----------------SQPNRQG-------------------------------------
------------------------------------------------------------
-----------------------------------------------QSSY---------
------YGQTDRQD---QYYHYDQTDRQGQSSH---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------YSQPDRQGQSSHYGQTDR-----------------------
-----------Q------------------------------------------------
---------G--------------------------------------------------
-----------------------------QYYHYDQTDRQGQSSHYSQPDREGQSSHYGQ
TDR-QDQNY------------HYGQTDR--------------------------------
----------------QGQS-----------------SHYGQTDRQGQYYHYDQPDRQGQ
SSHY--GQRDRQSQNSHYGQPDRQSQSSHYAQTDRQGQSYHYGQPDRQGQSS--------
----------HYIQSQT---------G---EI--QGQNKYLQGTEG-TR-----------
--K-ASYVEQSGRSGRLSQQTPGQEGY-QNQGQGFQSRDSQQNGHQVWEP----EEDSQ-
-----------HHQHKLLAQI--QQERP--LCHKGRDWQSCSS-----------------
-------------------EQGHRQAQTRQSHGE--------------------------
------------------------------------------------------------
--------------------------G---------------------------------
------------------------------------------------------------
----LSHWA------EEEQGHQ-----------------SWDRHSHEGQEGPCGTQDRRT
HEDEQNHQRQDRQTHEDEQNRQ--------------------------------------
--RQDRQTHEDEQNR-Q-------------------------RQDRQTHEDEQNRQRR--
------------------------------------------------------------
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----MMSARHQRLTSKMPQLLRNIHGIIEAFGRYARTEGS-CTALTRRELKRLLEQEFAD
VIVKPHD-----------PATVDEVLRLLDEDETGTVEFK-----------E-FLV-L--
-V---------------F-K-V-A-Q-A-C-FKT----LSESV-GGACK---S-----QA
SGGH-----HA-G----FSKELQE-GQRSGTNV--EQAGKGQHQEG--------------
-------SS-------------------------------------------------HG
HSEWA-----------TQQQGR---------------TGTQTQG----------------
------------------------QDISSPQVSTRDR------------------QAESQ
GQVQV-SQRTQVREHVEQTQRVGDSVSHQTRE------R--------------R-----S
ERQS-----QSSKH-----TGETI-TGTT-------------------------------
--------------------------------------------SQIQT--GATQTVEQD
RKHQTGSIQTQ--GSPYSQTRET----------------E--------------------
-----AHGQDTSQTSQ-----VVVGGHIQAQ-------------AGSHSQ----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----THKQSVEQDRSH----------------QTGSTSTQTQQSSCGQTEGTKALGQDKN
Q---------------TSQAV----KG--HI----------KSQAGSYTQTQ--------
-----------------------------------------E------------------
------------------------------------------------------------
----------------------QHWSQTASPIGDRG------------------------
---------------------------------------------------QGQTQ----
TQSGSDQRWTQASK--A-GQ----------------------------------------
---------SVLE-------------------------GQVQTGASTVTGKQDQSSTQP-
-SV----------TGGQQ-----------------------EREPT--------------
-------EVREEWVDDHTREI---VIRRQDEGS----PCT--------------------
------------------SAPSV-------------------------------------
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-------------

----------------MPRLLRNVLCVIETFHKYASEDSN-GATLTSRELKQLLQREFGD
FFQPCV------------LHAVEKNSNLLNIDSNGIISFD-----------E-FVL-A--
-I---------------F-N-L-L-N-L-C-CHD----VQS-----LLS---S-ELRQ--
-VTKP-EKEKPDD------VDLQATT---RD---------GQWTAG---TSPT-------
-----------QEER----------------MLPS----------------------GMA
SSSQLIPEES----------------GAAGNNRVD-PWREAKTHNFLGEASEHNDP----
---KNQHL-------------------------------------------------ERD
-------EQSQEVAQDIQTTEDNEGQ-LKTNK---PTAGSKQTSSPTK-RKG-QDKEISR
EGD-EP----AREQSVS------KIRDQF---------------GEQEGNLG--------
--------------------------------------------TQSSPSKEATQRPSE-
-----------------DQ----------EVRTEK-Q--K----------HSNTQEPPL-
------Q------------------GEGE-P-------------SSEHA---DLP-----
EQAAARTPSQTQ---KSTDPKDV--CRT----FDTQESRKDAD------------QTPAE
------------TKN--LGEPEDYCR---------------------TSETQE-------
------------------------------------------------------------
------------------------------------------------------------
------------------KECETKGLPVQYGSRNG----SETSDMR--------DERKER
RGPEAHGTAGQ-KE--------------------RDR---------------------KT
RPLVL-------------ETQTQDGKY--QELQGLS-------KSKDAEKGSET------
-----------------------------------------QYLSSEGGDQT-----HPE
L--------------E-------GT----A-VSGEEAEHTKEGTAEAFVNSKNAPAAERT
VGARE----------RTQD-----------------------------------------
--------------------------------------------LAPLEK-QSAGENTRV
TKTHDK--PVEEEDSYQ-----------------------------------GEDPESPF
TQSDEGSSEIPNSLASEEGNSSSETG---------------E------------------
--------LPVQGDSQ------------------SQGDPRGESA---------QGGDNNN
SDT---------------------------------------------------------
------------------------------------------------------------
---------------------------------------------QRQGTPGEKNRALEA
V------VPAVR------------------------------------------------
-GEDVQLTEDQEQSARGERK-N--------QGPG-----T-KGPGAAVEPSGHPEAQ---
---ESTAGD--ENRKSLEIELTGALDED--FTDQLSLMQLPGKGN---------------
-------------------SRNELKVQGPSSKEEKGRTTEAQNTLLKSLGEDNSASL---
--KIQLETKK-------PVTS-EEEDESPQELTGEGGDQKSPAKK-EDNSSIPWPSLEKQ
MQRDQEPCSVERGAVHSSPLYQYLQEKILQQTNVTQE--------------------EHQ
K---------------------------------QIQIAQASGPE---------LCS---
-ASLNSEISDCSVFFNYSQASQ---------------PYTRGLPLDESPAGAQETPAPQA
LEDKQGHPQRERLVPQREASTT----------------------------------K---
-----------------------------Q------------------------------
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-------------

----------------MSPLLRSIYAIAKTFNQYASHDCD-GASLSKKDLKNLLEREFGA
VLR RPND-----------PE TVDLILTLLDRDRNGQVDFK-----------E-F-L-L-L
-I---------------F-Q-M-A-Q-A-C-Y--Y-A-L-S-Q-A-TG--L-A------D
K--RA-Q-C-E-R-K-G-NL-L--QD-RTQ-EG-Q-R-----------------------
-------------------------------RF-------------------------KP
GERQLDEELG-----QLQTEKRQD----QER--EL-GEE-EEQREKQE-RLGQNKW----
-------------QRRD----------EE-------------------------------
-------------------------QRLQQRE--QQERERRAEEEHLWERKGRQAEEFPE
EEQGRW----RKRQE-------------------------LKRELREREQLQRR------
-------------ERQD-----------------PRERALEVDE----------------
------------------------------------------------------------
-------------EQQL--------RXXXXX-----------------X---XXXXXXXX
XXXXXXX--XXX---XXXXXXXXXXXXX-XX-XXXXXXXXX-----XX---XXXXXXXXX
XX--------------XXXX-----XXXXXXXXXXXXXXX---X----XXXXX-XXXXX-
-XXXXXXX------XXXXXXXXX-----XX-XXXXXXXXXXXXX--X-----XXXX----
X-XXXXXXXX---XXXXXX-----------XXXXX--XXXXXX-XXXXXXXXXXXX--XX
XXXXXXXXXXXX-----------XXXXX--------XXXXXXXXXXX---------XXXX
XXXXX--------X--XXXXX-XXX------X-XXXXXXXXXXXX---XXXXXXXXXXXX
XX-X----X------X--XXXX-XXXX-XXXXXXXXXXXXXXXXX-------------XX
X--XXXXX-------------X---XXXXXXXXXXXXXXXXXXX------XXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXEKEESPVLHFRRDQEERLDQQ
RR---------------------------------------------------EEERREL
QLRREQEEES---------------RALQLRR-----------------EQE--------
----------RREQQLWRPQEERLEQKGEKE-RRELQLRREQ-EEERR----EQELV---
---------------E--EE---EQE---------------QA-----RELGEKGTPKWQ
WQLESE-------------------------------ADARQSK---VYSR---------
PLR-QEEQ-----KLHQEQELQLR------EE-------R------------R-------
-------------EQ---------------------------------------------
--------------QERREQERREQQLREEAWQAEE-----ESHRRRQRLL---------
-----A-RPSLREQQERQQRTEERQ-E-----QWF------LQEKKQQ---------QRA
REQELQFREEEE-LQQLDRAGQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--
-XXXXXXX---XXXXXXXX-------XX------XXXXXXXXXXX-XXXX-----XXXXX
--XXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXX-XXX-XXXXXXXXXX-----------
------------XXXXXXXXX-XXXXXXXXX-----------------------------
-------------XX-----XXXXXXXXXXX-------------------------XXXX
XXX---------XX-------------XXXX-XX-X---XXXX-----------------
------XXXXX-------X--XXXXXXXXXXXXXXXXXXXXXQQLLRQYRE-EELQQEEQ
LQREKRRQERERQYREEE-LQQEEEQLRRG--------------E---------RE--KR
RQELERQYREEE-LQQEEEQLRREK--------------RRLEQERQ-------------
------------------------------------------------------------
------------------YR-EEEL---QQEEEQL---QREE------------------
-------------------------------------LEKRRQELERQYREEELQQE---
-----------------------------------EEQLQ---RE------RRRQERDRL
Y-----------------------------LEEEELQRQERKRQLQGEDKRSDLKW----
QWQPENERAIRKESVYSKRTGNEEKVQQLDN-SQVWE--KQQDRWLLLDEQE-------E
KREQERKRWQQQDRQFPAEER----KF------------------QEEQLLRE-ERDEKR
RPQERDRKFGEEEQLRQEREEEQLR-----------------------------------
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-------------

----------------MPQLLQNIHGIIEAFGCYARSEGG-CKVLTRQELKRLLEHEFAD
VIVKPHD-----------PATVDEVLRLLDEDNTGTVEFK-----------E-FLV-L--
-V---------------F-K-V-A-R-A-C-FKT----LNESP-KGACI---S-----DK
SESC-----YP-G----SSKELEQ-RQRGGAEV--AKDGAAQHCED--------------
-------SS-------------------------------------------------CG
QRDQA-----------SRGQDR---------------VGTHTQN----------------
------------------------QDSYPTQVSSHDR------------------QTESQ
TQEMI-SQQTQVTGQVEQTPRTEDKNW--TRQ------K--------------R-----S
ERQP-----QSSQQ-----TDEIT-TGST-------------------------------
--------------------------------------------AQTQA--G--------
--------NFYTQGSTCDYNRGT----------------N--------------------
-----SHHQDRSHADR------ASTQHYQTQ-------------AGSHTQIHTQMVEQAW
GQQTGSDSIQTQ---GSIYDQSRETV-----------------------------IHGQD
RNQ---------------ASQSVKE-----------------------------------
-------HHQAQAESY--------------------------------------------
------------------------------------------------------------
------------T-----------------------------------------------
------------------------------------------------------------
---QTHTQTMEQGRSQ----------------QAENSSTQTHGSMYGQNRETEIHGQESS
Q---------------VEQVGT----R--HY----------QTQAGSYTQTL--------
-----------------------------------------E------------------
------------------------------------------------------------
----------------------HDGSQSAHKFVAQE------------------------
---------------------------------------------------KEHTQ----
TKPCMGQSWTPVSNYET-EE----------------------------------------
---------PVIG-------------------------GQVQTETDTVIE------NHP-
-SP----------TARQV-----------------------ERVPT--------------
-------VVREEWVNDHTREI---VIRSQDPGS----LHS--------------------
------------------GTSSAQGQDIPQ------------I--EKKGIT-AKG-----
----------L--------------------------YTYLKTEQP--------------
------------------------------------------------------------
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-------------

----------------MTDLLRSVVTVIDVFYKYTKQDGE-CRTLSKDELKELLEKEFRP
ILK NPDD-----------PD TVDVIMHMLDRDHDRRLDFT-----------E-FLL-M--
-V---------------F-K-L-A-M-A-C-NKV----LSK---E-YCK---A-------
SGSKKHRRGHR----------HQKEESETEEE--------EE-------DTLG-----QK
SGYRHSSWSEG-EEHGYG---SEGLRGRMKHRHGP-----------------------N-
-SRRLGRQ----------------------------------------------------
---------------------------GHSWN--------S--GKERHGSSS-GELGERR
N--------------------------KSHS-------------RESR------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------GQKLGS-----SSRSSGNNGRQSYACG
SS---------------------------------------------------------N
SGGCGRP---QN---ASTSCHEGRFGGQGNQSSCT-QSGYQSGSSGGLGHGCNSGGQSSG
YGQ-----HEPSSCS-QSSSQREYGS----------------------RACGQ--TQNC-
GRQQRTG--SSQSSCCEQY-----------------------------------------
-----------------------------------------------G-------S----
-GTSQSSSYGQY-----------ESGSC-GHFSKSHQKGSGSNEFT--------------
---NC--------G--QHGSGSGQS------S-GFGK-----------------------
---------------------------------------HGSASG---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------QS-
------------SGFG--YGSGSCQ-----------------------------------
-----SSGFGQHEFGSGQSSGFGQHG-----------SISGQSSSFGQQG----------
------------------------------------------------------------
-------------------------------------S------GSGQSSSFG-------
----------QH-GS-------SLG-----------------------------------
-----------------Q-----AS-G-----F---------SQHGSGS-----------
------------------------------------------------------------
-GQSSGFGQ--HR---------------------SSS-----------------------
----------------------------------D-------------------------
---------------------------QSSSFGQQ-----GS------------------
------------------FSGHSSG-----------------------------------
------------------------FGQHGSV------SGQSFG-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------YGQH-----------------------
-------GFGGHESSSSGQHRY----G---------------------------------
------------------------------------------------------------
------------------SGQSSSFGYG-SSK----HQSP---------T----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------SG--------TGSG-HSLGF--GQHES------
-------RSG------------Q-SSYGQHSSSSGQSASFGSGSSSGKS-----SKHSQC
ES-----NSRQSSSY---------------------------------------------
---------------------------------DQHEVNSGQSTG--------YD-----
----------KYDPRLGGEE----------------------------------------
--------------------------SYRTCSGKGSPKS--ESPIPDS------------
--PETQ----TR------------------------------------------------
-----------ETTKGRHETT---------HAQSGD------------------------
------------------------------------------------------------
----ISGH------AGF----GHSQATRTE------------------------------
----------------------------SRRTA---------------RKGS-------S
L------S----EPSNTEWHSEVP------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------Q
THAGSSH-----------GHTG----------------------------S---------
---QQGDSGSAAKG--RQGNTPA-------------------------------------
-----QSRETSRHGQLGHGQATSTEMSSE-------------------------------
-------SSDTERHSGVSQTHTGSSHGHTGSHHAGSGST---------------------
---------------------------------APGRQGTSHRQ----------SGD---
-------------------TSRHVQTSDGQATRTASSRA-----TRRRSSG---------
------------------------------------------------------------
--------SESSDTTHAGSSHGHTGSQHGESGSIAL------------GRQGTTHEQS--
--GHTNRH------AQSGHG---------------QTTRAGSSRTAR-TGSSLSESSDTE
KHSGVPQ----THAGSSHDHSGSQQRESGSS-----------------------------
------------------ATGRHGTTHAQS-----------------------GHSIGHT
QTGHGQATGTQSSRA-TRRSSVSESSDTEWHSGVPQT---------HAGS--SHGHTGSQ
KGESGTTATGRQGTTHAQSGDTSRHSQTSHGQATRTASSRATRRRSRGSESSDTERHSGV
SQTHAGSSHGHTGSQHGESGSIALGRQGTTHEQSGHTNRHAQSGHGQTTRTHAGSSH---
-DHSGSQQRES------------------------------------GSSATGRHGTTHA
QSGHSIGHTQTGHGQATGTQSS--RATRRSS--VSESSDTEWHSGVPQTHA--GSSHGHT
GSQKGESGT--TATGRQGTTHAQSGDTSRH----SQT---SHGQATRTASSRATRRR-SR
GSESSDTEGHSHSHELTGDKSTYSGSVQGQT---TSSHG---QLGTGTIERRGSSHTQSR
SSHGHTGSQHGESGSIALGRQGTTHEQSGHTNRHA---------------------QSGH
GQTTRAGSSRTARTGSSLSESSDTEKHSGVPQTHA--GSSHDHSGSHQRESGSSATGRHG
TTHAQS-------------------------------------------------GDTSR
HTQTGH---------------GLATGTQSSRATRRRSSGSESSDTDRHSVNPQTHTGSSL
GHTGSQQGDSGSTALGRQGTTHGQSGNA-------RGHAGLGHGQAT--RTESNRTARRG
SSLSESSHTERHSGVSQTHAG-----S-SHGHTGSQHGESGSIALGRQGTTHEQSGHTNR
HAQS--------------------------------------------------------
------------------------------------------------------------
--------------------------------GHGQTTRAGS---SRTARTGSSLSESSD
TEKHSGVPQTH-------------------------------------------------
--------------------------AGSSHDHSGSHQRESGSSATGRHGTTHAQSGDTS
RHTQTGHGLATGTQSSR-----------------------------------------AT
RRRSSGSESSDTDRHSVNPQTHTG----------------------------SSLGHTGS
QQGDSGSTALGRQGTTHGQSGNARGHAGLGHGQAT----RTES-----------------
-------------------------NRTARRGSSLSESSHTERH--SGVSQTHAGS----
--------------------------------SHGHTGSQHGES----GSIALGRQGTTH
EQSGHTNRHAQSGHGQTTRAG------SSRTARTGSS-----LSESSDTEKHS-------
-----------GVPQTHAGS----------------------------------------
--SHDHFGSHQRES----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------GSSATGRHGTTHAQSGHSSGHTQTGHGQATGTQ---------SSRA--TRRS
SVSESSDTEWHSGVPQTH------------------------------------------
------------------------------AGSSHGHTGSQKGESGTTATGRQGTTHAQS
GDTSRRSQTSH---------------GQATRTASSRATRRRSRGSESSDTERHSGVSQTH
T-----------------------------------------------------------
-------------------------------------------------GFSHGPTRSQH
GESGSTAKGRQGTTHTQSGHSSGHTQTGHGQATGTQS----SRATR--------------
------------------------------------------------------------
--------------------------------RSSTHAGSSHGHTGS-------------
----------------------QKGESGTTATRRQGTTHAQSGDTSRRSQASDGQATRTA
SSRA----------TRRRSR------------GSE-------------------------
-----------------------------------------SSDTEGHSHS---------
-----------------------------------------------------HELTGDK
STYSGSVQGQTTS--------SHG----------QLGTGTIERRQGWK---HGSYGSAE-
-------------------------------YDYGQSGAANNQVSTHGPS----------
-------------------VSRFDHTGSK-------ATEIIRRQSSSHG-QSSDSHNQSG
SNVTRRQGS-IHGHSVVSHEPSNDTHVQ-------YGSWG---S-----------I----
-----------------------THRQSSNHSISSHGQSISDHSYSKS-NSTLRHGSHSD
NKEHSEDWGKQIHEPSGSR---HG------------------------------------
------------------------------------------------------------
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-------------

----------------MPQLLNSILNVNKVFQNYAEHHGA-GASLSKKELKQLLLAEFGD
ILRRPND-----------PETVETILEHLDRDRNGYVDFH-----------E-YLL-L--
-V---------------F-Q-L-V-Q-A-C-HHK----LDS---K-LHG---T-------
GTSFQKEHGQE-G-----TQSHKFSEN-TSR---QH----KQRYQGQRQ-----------
-NSHHS-QSEGR-QNVQH--DQ-SQRQNKDS-----------------------------
-----------------------------EKHDTD---PHYGQSETFHGDSHYGHSEKSD
TDYSSDQSE------------SDGQSSSSSQRLSY-------------KSSH--DQPKGQ
G--YI-------F-------------ALYQSE------NP------AQ-----------A
SHYGQS-----------------KTFGEQS------------NRGQ-SGRFR--------
--------KESYSSQTS----------------QESDSYEQY-GNQHQ-KSGHSQTERQG
QKSQYGQTNKKGHSSYHEQTD---------------------------------------
-----------------RQDKSFHYGQKGRQDQ------------GFQH---GQKDKQDQ
SSHQGQKGRED---QSSHQSQKGRRG-Q--S------P-----------HQGQKGRQGQS
-------------------P--HQG-------------------------------QK--
---GR----QGQSPHQGQKGR----ED-QS-------------------FHQ--------
GQKGREDQSFQQGQKGRGDQ-----------S------SHQ------------GQKGRG-
---DQSSHQGQ------------KGR--QDRSPHQGQ-----KGREDQSSHQ-G--QKGR
QNQSS-HH-GQIEDQD-QSSRWHQSD----------------------------------
-------------------RQD-------HGFHYGQTGGQGQSSHHGQTE---DQDQSSH
WHQTDRQDRGFH----YGQTGR--EGQSS-HQGQ----ADRQGQISHQGQKGRGD-----
------------------------------------------------------------
------------------------------------------------------------
------Q---------SSHQGQKGRGDQSSHQGQKG------------------------
----------REDQSFHQGQK-GRGD-------------------------QS---SHQ-
GQK---G-------------------------------------------KDQSF----H
QGQ--------KGR-EDQSSHQGQKGRGDQSFHQGQKGREDQSFHQGQKGREDQSSHQGQ
KGR-GDQSFHQGQKGREDQSSHQGQKGRQDQSSHQGQTGGHSQSSHQGWTREESQSSHQG
QTGGQSHSSPQGWTREESQSSHQGQIGRQGQS-----SHQGQTDNQDQSSRWHQTDRRGQ
SFQH--GQTGEQSQSSHQGQTGSQGQSSQWHQSDRQGQSFHHGQRDREGQSS--------
----------HQGQTDRQSQSSHCGQSDTGKTEFQGQNKHFQGTDR-TR-----------
--R-DSYVEQSGRSGKLSQQNSREEGN-QTQRQRSQDRREQQIQHQAWKP----EEDN--
-------------QHKLLAQV--HQ-EP--YSHEEYDSQSQSS-----------------
-------------------EQGH-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------WG-------EEEHHQ-----------------DWDRHNVEDQESLYEMQNWQT
HEEEQNHQRSDRQTHADEQNKQ--------------------------------------
--RQHRQTHEENHDH---------------------------QHGRQD-EEEQNHKR---
-R----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------G--------------------------
---HHQQWDRHTHEENEKYQGGQGQ-----------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------FRTFPNKEKFHRNEE--------------
----------------------DQYEGS---------QGRHFH------------PTHSG
ERSQRREKSGNHATKTA-NTSSPFYDYVQEQAAYHY------------------------
------------------------------------------------------------
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----------------MAQLQENINGIIAVFYNYARKDGD-CSALSKGELRQLIEQEFAD
VIV NPHD-----------PN TIEKVLRFLDEDSNGKVEFS-----------E-FLS-L--
-V---------------F-R-V-A-K-A-C-YRQ----LEQCQ-APEDG---Q-----ET
TVQE-----KA-G----GVPE---------------------------------------
------------------------------------------------------------
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-------------

-----------------SKLIQCITTIIDIFYQYATPDGE-CEMLNKAELRELLENEFHQ
ILKNPDD-----------PDTVDVIMQNLDHDHNKKVNFT-----------E-YLI-M--
-I---------------F-K-L-A-K-A-F-NKI----MGK---D-YCQ---A-------
AGSKQKGHSYQ----------HQEEQSETEEE--------D----------GE-----QE
SSPSYSRGRAG-EDDSYN---KGS-RY---------------------------------
------------------------------------------------------------
-------------------------------------------LKHRPRSSS-QRK----
----------------------------------------------------GH------
---QED-------------------LPSQS------------------------------
----------------------------------------FSS-DQEWSDSK-DSVENR-
--QHKKK----SEKSANK-----------RDER------F--------------SAGQS-
---------SRHSQ----------------------------------------------
--------------------------------------------------HGSGEGQSSR
-------------HG-RHESG-----S--------------------GQSSS--YSHQG-
S-----T--SGQSSGHSQH----------------GSRSGQSSACGKPRSGSGSGSGSGS
GQSSGRGRHSSG------------------------------------------------
--SGRSPSPGHH-----------GSGS--------------------------------R
QSTGL--------D--RHGSGSGHS------S----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------SSSQHG-----------SRSGQSSTYGHKGG---------
S---GSGQS-----------S---------------------------------------
------------------GYGQH---G----------S------GSGQSSGLG-------
----------RH-HS-------GSGESSG-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------TGEYGS------------------------------
----------------------------------------G-------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------SGQSSSYGHH-----------------------
-------GSTWGQSSGCEQSGSSS----------------------GRSSGYGHQ-----
----------ESGS----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------GHSSRQGRHR--------SSSG-SSSSY--GQHGS------
-------HSG------------QASGHGQHGSESGQSSRHSQHGS-GEGQSSRHGR----
---------------------------------------------H-EFGSGQSSSYGHQ
-GSTSGQ---------SSGHSQHGSRSGQSSACGKPRSGSGSGS--------GS------
------------G-SGQSSGRGRHGSGSGRSLSPGHHGSGSGQS-TGLDRHGSGSGHSSS
SSQHGSRSGQSSTYGHKGGSGSGQSSGYG-----------------------QH------
GSGS-GQS----------------SGLGR---HHSGS------------------G----
----------ESSGTGEYRSG---------SGQSS-------------------------
--SYGH-----------H------------------------------------------
---------------GS----TWGQS----------------------------------
------------------------------------------------------------
----------S-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---GCEQ-----------SGSSSGRSSGYGH-----------------------------
-------QESS-SG--H-----------------------------------SSRQG-RH
--R-SSSGSSSSYGQHGSHSGQASGHGQHG-SESG--------QSS-RHSQHGSG--EGQ
SSRHGRH--------------------------------------EFGSGQSSSYGHQGS
TSGQSSGHS--------------QHGSRSGQSSACGKPRSGSGSGSGSG----------S
G----S-----GSSSGSGQSSGRGRHGSGSGRS---------PSPGHHGSSSGQSTGLDR
HGSGSGHSSSSSQHGSR------------------SGQSSTYG------------HKGGS
GSGQSSGYGQHGSGSGQSSGLGRHHSGSGESSG-TGEYGSGSGQSSSYGHHGSTWGQS--
--SGCEQSGS--------------------------------------------------
------------------------------------------------------------
----------SSGR--SSGYGHQESGSGH-------------------------------
------------------------SSRQGRHRSSSGSSSSYGQHGSHSGQASGHGQHGSE
SGQSSRH-----------------------------------------------------
---------------------------------------------------SQHGS----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------GEGQS------------------------------------------SRHGRHE
SGSGQS-SSYGHQGSTSG--QSSGHSQHGSRSGQS-SACGKPRSGSGSGS---G------
--------------------------S-----------------GSGS--GQSSGRGRHG
SGSGRSPSPG--------------------------------------------------
-----------------------------HHGSGSGQSTGLDRH----------------
------------------------------------------------------------
----------------------------GSGSGHSS-------SSSQHGSRSGQSSTY--
-GHKG---------------------------------------------GSGSGQSSGY
GQHG--------------------------------------SG----------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------SGQSSGLG
R-HHSGSGESSGTGEYGSGSGQ--------------------------------------
----S-----S-------------------------------------------------
SYGHHGST----------------------------------------------------
-----------------------------------WGQSSGCEQSGS-SSGRSSGYGHQ-
----ESGSGHSSRQGRHRSSSGSSSSYGQHGSHSGQASGHGQHGSESGQSSRHSQ-----
--------H-GSGEGQSS----------------RH------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---GRHESGSGQSS-----------SYGHQGSTSGQS-----------------------
-----------S-GH-------S-------------------------------------
------------------------------------------------------------
-QHGSRSGQ--------------SSAC---------------------------------
------------------------------------------------------------
------------------------GKPRSGSGSG--------SGSGSGQSSGRGRHGSSS
GRSPSPG--HHGSGSGQST-----------------------------------------
----------------------------GLDRH---------------------------
------------------------------------------------------------
----------------------GSGSGHSSSSSQHGSRSGESSTYGHK------------
-GGSGSGQ--SSGYGQHGS--GSGQSSG---LGRH---H--------------SGSGESS
-------------GTGEYGSGSGQSSS--YGH---------HGSTWGQSS----------
-----------------------GCEQSGS--------S-SGRSSGYGHQESGSGHSSRQ
GRHRSSSG-------------------------------------------------SSS
S-----------------------------YGQYGS-HSAQSSG----------------
----------HGQHRSESRQSS-----------------RHSKHGS--QSGSDCGLENIY
AFSHKFCSSSP-L-YLYI------HEQR--------------------------------
------------------------------------------------------------
------------------RSFQT-------------------------------------
------------------------------------------------------------
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-------------

----------------MPRLLRSVLCVIETFHKYAREDGD-GVTLTHRELKQLLQGEFGD
ILQPHV------------MHAVEKNVNLLDIGSDGTIRFD-----------Q-FVL-A--
-T---------------C-N-L-L-N-H-C-YLD----IQS-----LN----S-EPRQ--
-APKP-EKENPGD------VDPQATS---RS---------GQLTEE---TPPT-------
-----------QDKV----------------VLPS----------------------GMA
PSSQLNPEER----------------EPVEHNRVD-PQEDSKTHNLPGEASEHNDS----
---KNQHL-------------------------------------------------EGD
-------EQIQEVAQHVQTAGDNGAQ-LETNK---EMVTSKQTSSPTE-VEG-QDKEIPR
EAE-KP----AGEQSHT------KARDQL---------------GEQE------------
------------------------------------------------------------
---------------------------------EK-GIKE----------HSKTQEPSL-
------Q------------------AENE-S-------------SSEQA---DLP-----
EKAAEGKQSPTQ---KLTDPEDE--GRI----SETQEPGKDAS------------RTPPE
------------TKI--TAEPGDDGR---------------------ISETQELRA----
------------------------------------------------------------
------------------------------------------------------------
------------------QEQETKDMPVQGDGKNI----SETHYVT--------TERKLG
RGPETHGTTWQ-KG--------------------SKR---------------------KT
QTPAL-------------EVQTQEGMY--QELQGPS-------KERDTAKGTET------
-----------------------------------------QDLGSEGTDQS-----HTE
I--------------E-------GA----A-ALGDVRY--IEKGREALVGSKNAPVAEGT
AGARE----------RTQE-----------------------------------------
--------------------------------------------SAPLES-QSVGKKRRI
TKTQDK--STKEDDSYQ-----------------------------------GEDPVPPT
TQNDEGFFKTPNSLAPEEGDSSLETG---------------D------------------
--------LPAQRDSQ------------------SQVDPPGESV---------QGGCNND
PDA---------------------------------------------------------
------------------------------------------------------------
---------------------------------------------QKQAGSGEKYRAQEA
V------VLAVR------------------------------------------------
-----QLTDEQEQFLRGEHK-S--------WGSG-----T-KGPDPDVEVNGLPEAQ---
---QSTAGG--DNGKSVKAEIPGALDAD--------------------------------
------------------------------------------------------------
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-------------

----------------MPQLLRDILYVIETFYNYAKEDGN-KATLTCRELKQLIQGEFGD
ILQPSV------------IHAVERKLDLLDIDSDGNITFE-----------E-FLL-A--
-I---------------F-N-L-L-N-L-C-YLD----IQS-----LLN---S-EARP--
-MSKS-GE-KPDD------VVLQTNT---RT---------CQMTKG---ILTM-------
-----------QDKE----------------QLPS----------------------GTE
SSTQLSPDER----------------GEDEYNRAE-QQGDIKTCRLPEELSWISVH----
---RNQHL-------------------------------------------------VE-
-------EQSQDGSQEAYTGENNEVQ-LETNK---ATAGH--TGSSTK-QVG-QDKEIPG
ERN-EP----GRGQSDW------ETRQQF---------------GGKGGNLG--------
--------------------------------------------IQSSPQEATTQKPFR-
-----------------DQ----------EADLEM-NVKE----------HNKIQAVQ--
-------------------------EKDD-L-------------R---------S-----
EQTIAQKSCLTQ---KLTEPEDK--RKK----SE----TEEAK------------KTPSE
------------TKN--SAYGAD--T---------------------ASEIQEPPAQK--
------------------------------------------------------------
------------------------------------------------------------
----------------------TKELPVQGGGRSA----SETPDVR--------GKRKER
RDPDVCGIEEQ-RE--------------------SER---------------------KT
QPLGL-------------VDQTQ--KY--QEHQESL-------KERDTQKCSMA------
-----------------------------------------QELSLEGRKKN-----HPE
I--------------E-------RV----A-VPAEGARLAEKSKAETLSDEHALAAAAGA
LGPRD----------RKQE-----------------------------------------
--------------------------------------------LEPLEN-KSGTKNERT
DQTSDK--SVNEDGGYQ-----------------------------------GQDHEPTV
TKIDERSSKTCSSPVPKARNSSSETS---------------N------------------
--------LSVQGKSQ------------------RPADALGESV---------QENRNSN
PDT---------------------------------------------------------
------------------------------------------------------------
---------------------------------------------QEQVTQDEENVTQEI
V------VHSDR------------------------------------------------
-EEDEQLTEEQRLPVDVKHQNN--------QSSG-----T-KDPGPARESSRYLECQ---
---ESLEEG--KNTKSLKMEVPGALEKD--LTDQFSVTELAAKEN---------------
-------------------SRKEIQVLIASTREDEGETPNIKKNLVKSINENNSASS---
--KTHLETQE-------PATW--KEKESRQALKED--VQQESLNK-GHNSSVSQSDLKEM
TQKDQPSFSMEKGTVYSNPLYMYLQKNVLQQRDITQD----------------------Q
N---------------------------------QALPVKSSSPG---------LRNNPS
DVSLTG----------DSQVSQ---------------QCTKELLFDEDKEDIKAAS-TQA
REV--KQPYREKSVSQIEASKT----------------------------------K---
-----------------------------F------------------------------
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-------------

----------------MSPLLRSIFNITEMFNQYASHDCD-GAALSKKDLKNLLEREFGD
VLRRPHD-----------PETVDLILELLDRDCNGLIDFN-----------E-F-L-L-F
-V---------------F-K-V-A-Q-A-C-Y--Y-A-L-S-Q-A-SG--L-D------E
K--RA-K-C-E-G-R-E-NP-L--QE-PRQ-ED-Q-R-----------------------
-------------------------------RF-------------------------EP
QDRQLEERRQ----------KRQE----LER--EL-AEEEK-----------QRLQ----
---------------------------------------------------------RRE
P------------------------------------EERLEEEEHLQGRKGRELEKFSN
QEQSQE----RREQRELQKEVQLQRLERQEQ--RERA---LQEEE-QLEPQRLK------
-------------ETRL----------P-QELRRVQERREQELRREEQ-RLEQELQLKQE
-----------------------------ERREQE-LRRE-------------E--PRL-
-----EQELRR-QQEER--------RKQEQR-----------------------------
----------RE---QEERRQQLRREQE-RR-AQE----LR-----RE---E-------Q
RL--------------EQEP-----RLEQEERREQELRRQQEER---RK-----------
----------------------------------------------------QELR----
R-EQE-ERCQ---HLRREEQRL--------EQELRREQEL------RREQ-ERREQ--EL
RSEEPR----------------------------------------------------LE
QELKR--------E--QELKR-EQQ------L-RCEQQ----------------------
-----------ERREQELRH----------------------------------------
--------------------------------------------------------EEQR
LEQELRRKQK---------------------------------------------RREQK
LRREE--------------------------------------------PRLEQELRREQ
QLSRE----------------QEERLEQELRQEQEERRQQLRREEQRLEQEL--------
----------RREQQMKQEQEERREQ----L-R-REE-QRLE-QQLRR----EQELR---
---------------R--EE---PRX---------------XX-----XXXXXXXXXXXX
XXXXX-------------------------------------------------------
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-------------

----------------MTDLLRSVVTVIDVFYKYTKQDGE-CGTLSKDELKELLEKEFHP
VLKNPDD-----------PDTVDVIMHMLDRDHDRRLDFT-----------E-FLL-M--
-I---------------F-K-L-T-M-A-C-NKV----LSK---E-YCK---A-------
SGSKKHRRGHR----------HQEEESETEED--------EE-------DTPE-----HK
SGYRHSSWSEG-EEHGYS---SGHSRGTVKRRHGS-----------------------N-
-SRRLGRQG------------------------NLSSSGNQEGSQ-KRYHRSSS------
---------------------------GHSWS--------S--GKERHGFSS-GELRERI
N--------------------------KSHV-------------SPSR----EF-----G
EEYESG-------------------SG---------------------------------
--------------------------------------------SKSWERKGHGGLSCGL
EIS--GH-----E-SNST---------QSRSR-GQKLGSS-----RSCSGDSRRRSHECG
YS---------------------------------------------------------N
SSGCGRP---QN---ASNSCQSHRFGGQVNHSSYI-QSGCQSGINGGQGHDCVSGGQPSG
CGQ-----PESNSCS-QSYSQRGYGA----------------------RENGQ--PQNC-
GGQQRTG--SSQSSFCGQY-----------------------------------------
-----------------------------------------------E-------S----
-GGSQSCSNGQH-----------EHGSC-GRFSNSSS----SNEFS--------------
---KC--------G--KHRSGSGQF------T-SCEQ-----------------------
---------------------------------------HGTGL----S-----------
---QSSG---------FEQQVA---G-----------------SSQTCSQY---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------GSRSSQS-
------------SGYDE-HGSSSGK-----------------------------------
-----TSGFGQYRSGSGHSSGFGQHG-----------SGSGQSFGFGHY-----------
------------------------------------------------------------
--------------------GQH---G----------S------G---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------S-------------------------
----------------------------------R-------------------------
---------------------------QTSGFGQH-----EL------------------
------------------SSGQSSS-----------------------------------
------------------------FGQHGSG------SGQSSG-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------FGQH-----------------------
-------GSGSGQSSGFGQHES-RS-R-QSS--------------------YGQHG-SGS
SQSSG-YGQHG-------------------------------------------------
------------------SKWTSGFGQHSSGS----GQS----------T---------S
FGQYG-SGS-GQ--YSGFG-QHG-SGSGQS---SGFGQHESRS--GHS------------
--------------------------------S-C-------------------------
------------------------------------------------------------
-------G--------------------------QH-GFG--------SS-QSSGC----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------GHNG--------SSSG-QTSGF--GQHEL------
-------SSG------------QSSSFSQHGSGSGQSSGFRQYGS-GSG-QSS-GF---G
QH-ES-RS-HQ-SSY-G-PHGS-GS-GQ-SS----------GYG-QHGS-----------
---SSGQ---------TSGFGQQGSSSSQYSGFGQHGSGLSQ------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------S--S
G-FGQ-H-----------GT-GSGQFSGFGQHES-RSHQSS-YGQHGS-GSSQ-SS----
---GYGQHGSS-SG--H--TTGF-GQ-------------HRS---SS---GQYSGFG-QH
GSGLG---QSSGFGQHGTGSGQSSGFGQHE-SRSH--------QS--SYGQHGSG--SSQ
SSSYGQHGSSSGQTSG------------FGQHRSGSGQSSGFGQYGLGSGQSSGFGQHGS
GTGQSSGFA--------------RHEYRSGQ-SSYGQHGTGSSQSSGCGQRESGSGP---
-------------------TTGFGQHVSGSDNF---------SSSGQHISGSGQSTG---
------------------------------------------------------------
-------FGQYGSGSGQSTGLGQGESQQVASGSTVH------------GRQETTHGQT--
--INTARH------SQSGQG---------------QSTQTGSRVSRRRR-SSQSENSDSE
VHSRVSH----RHSEHIHTQVGSHYPESGST-----------------------------
------------------VHRRQGTTHGQR-----------------------GDTTTHS
HSGHGQSTQTGSRTTGRQRFSHSDATDSEVHSGVSHR---------PHSQEHTHGQAGSQ
LGESQSTV----------------------------------------------------
-----------------------HERHETTYGQTGD------------------------
------------------------------------------------------------
----ATGHGYSGHGQSTQIGSG--TTGRRGSGHSES-SDTEVHSGGSHRPQSQEQTHGQA
RSQHGESGS--TVHERHGTTHGQTGDTTRY----AHC---HNGQSTQRGSRTTG-RG-SG
HSEYSDSELYS-----------------------------------------GGSHTYSG
HTHGQVGSQHGESDSIVHEKYGTTHGETGDTTRHA---------------------HYGH
GQSTQRGSRTTGRRGSGHSEYSDSEGHSGISHTH--SGHTHGQAGSQHGESGSSGHGRQG
TTHGQT-------------------------------------------------GDTTR
HAHYG---------------HGQSTQRGSRTAGRRGS-----------------------
------------------------------------------------------------
-GHSEYSDSEGHSGTSHTHSG-----H-THGKAGSQHGESGSAVHGRQGTIHGQTGDTTR
HSQS----GHGQS-------------------------T-QTGSRTTGRRG-SGHSEYSD
SEGH-----------------------------SGISHTHSGHTHGQAGSQH------GE
SGS------SGHGRQGT-THGQTGDTTRHAHYGHGQSTQR--GSRTAG-RRGSGHSEYSD
SEGHSGVSHTH-------------------------------------------------
--------------------------SGHTHGQAGSQHGESESTVHERQQTTHGQTGDIT
EHGHSSHGQTTQTGSRT-----------------------------------------TG
RRGSGHSEYSDSEWHSGVSHTHSG---HT----------------HGQAG---------S
QHGESGSAVHERQGTIHGQTGDTTRHGQSGYGES-------TQTGS--------------
-------------------------RTIGRRGSGHSEYSDSEGH--SGVSHTHSGH----
-------------------------------THG-QAGSQHGES----GSALHGRQGTIH
GQTGDTTRHGQSGHGESTQTG------SRTTGRRGSG-----HSEYSDSEGHS-GGSH--
---------------THSGH----------------------------------------
--THGQAGSQHGESG---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------SAVHGRQGTIHGQTGDTTRHGQSKYMGSPYR-----------------QGP
GQLEEGDLATVSTGSHTHI-----------------------------------------
----QDTLMAKPDLN---------------------------MRVRITVHERQQTTHGQT
GDITEHGHSSH---------------GQTTQTGSRTTGRRGSGHSEYSDSEWHSGVSHTH
S-----------------------------------------------------------
-------------------------------------------------GHTHGQAGSQH
GESGSAVHERQGTIHGQTGDTTRHGQSGYGESTQTG-----SRTIG--------------
------------------------------------------------------------
--------------RRGSGHSEYSDSEGHSG-VSHTHSGHTHGQAGS-------------
----------------------QHGESGSAVHGRQGTIHGQTGDTTRHGQSGRGQFTHTG
---S-------RTTGRRGSGHS------------E-------------------------
-----------------------------------------YSDSEGHSGV---------
-----------------SHT--HSGHTHGQAGSQHGESG----SALHGRQGTIHGQTGDA
TRHGQSGHGQSTQTGSRTT--G---RRGSGHSEYSDSEGHSGVSHTHSGHTHGQAGSQH-
--GESESTVHERQQ----TTHGQTGDI----TEHGHSSHGQTTQTGSX-XXXXXXXXWKK
GIWPQ-------------------------------------------------------
------------------------------------------------------------
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----------------MPQLLQSVIYIIETFQNYAREEDD-CSTLSLGQLRQLLLREIGE
F-LKPFD-----------TLTTESSLNVLDREDNETISFN-----------E-FLL-L--
-V---------------F-D-L-L-N-I-C-YRD----IQS---F-LNL-ESKAKSDIEE
ELSGGMETCETN-------EDYQEEAELDQDKQ---RLT--DSE------SPS-------
-------LVNP-I--------E------------------------------------NV
PDTLSKEDSQDDL-ENPRLLEREIERDYTKNKY-----QSEGDHQSQ-------------
---E-----------------------RG-QVQARGGDGVSLEEKELPK-----------
E--FV----------------------KRTCS---QKDEKIVSEEHEV----------PR
QQDDANTGDQPSEQEGE-------------------------------------------
----------------------------------------QNVEIL---SE------QRA
Q---TT----------------------SESQEGA-IIKD-------------AEEHTE-
-----TQKPSS-QENQE--------KESETA---------------------DLP--TEK
AEEKLSD---TK---RLSEFSDDD--RT----PDIQEPLE--------------------
--------QE-REYETQDIV--VKGNN--------------------SRVP---------
---------------------EI-----EVLIDERKGKRK------LK------------
-------NLETVGKKENEK---------GNQMEIFTEQESDG-----------KEK----
---QLE---GLA-----------EEGDI--------RKDSETPDSKA-DNQN-HPECKGP
AASEE--------E--VTVSK-ISE------Q-EFS---------------------GDN
R--------------S-----------------ASAAEKIPETKDRVQG--------SGP
QDDQSGEGD-EK----ITQTLD---QSTEQYDGNKVQSQNDGTISETCNNPEEDESGS-E
LK------DL---------------------PAQRNCQSQV--DA-----Q---------
-------------ELPDQE-----------------------------------------
-----------------------------------DGKN---TQESPVLSD--------K
SRTPETEVPIARED-ENNAEEQLAEEKEKKS-----SVPKTP-----AMIEES-------
-------------------V---SQP---------------ASQESMKQN---------V
IEITDPID----------------D------------EYKQLSI---VQQS---------
E------------------KEYYG----KDPE-------AHDPDT-----E-E-------
-------------KGEESESQEV---P----------L-------EGQDLEMQ-------
--------------DLTMDS-----SSDTLNPMAKE-----DQ--SPQRQAGEVSEQQHV
MNKEEDSLPRLSEQIDRKSRD-----------T------ELCL-----------------
------------------------------------------------------------
---SSGDEI--DSKLVV----ENLQKIS------AQPDLPAPEQD----V-----SQTDT
----------SQ--ACGTELRVERESQRSKTS-EFPVL----LHPLCDYR--QEP-----
--RHQVEDPE--------------------------------------------------
-----------------------PDEEYVNQ-----------------------------
----------------------QEILIYQS------QEDDQIQ-------Q-EEQQE--I
DG-SSLKC----------------------------------------------------
------------------------------------------------------------
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-------------

----------------MPQLLNSILNVIRVFQKYASENGD-STSLCKNELKQLLLTEFGD
ILRRPND-----------PETVENILNHLDRNRNEHVDFR-----------E-YLL-L--
-V---------------F-Q-L-V-Q-A-C-HYR----LEN---K-SCG---D-------
RTSQ-QEKKHE-V-----TQDHKFPGG-TGR---EH----KQSHVGERQ-----------
-NSHHS-QSERQSHDGQH--DQ-SEKQDMDSH--------------------------YS
QSERLTID-------------------------RD---FHYGQPKTQDQDSHHGQFERQD
KDFHYGRSESQDGDSHH-------------------------------------------
----------------------------------------------AK-----------D
LHYSHS-----------------TKLGQQS------------RYVQ-SGRLT--------
--------QDICSNQTN----------Q-----QESSIYYEQSGRLDQ-ESGHGQRNRQG
LDSQYVQTDRQSQSSQYGQID---------------------------------------
-----------------RQGQGSHYGQTDVQGQGSHQGQTDRQNQSSHY---GQTDRQGQ
GSHYGQVERQG---QSSHHGQTDRKE-K--G------F-----------HYGQTDRQGQG
-------------------S--YHG-------------------------------QI--
---DR----QSQSSHYGQTDRQGQGSNHSQ----LD-RQSQN----------RQSQSSHY
GQTDRQGQGSNHSQLDRQSQ----------------------------------------
-----SSHYGQ-------------------------------TDRQGQGSHY-G--QVER
QGQSSLHIQTDRQE---KGFHYGQLEGQGQGSHH-GQIDRQGQSSHYGQ---T---D-RE
GQN---------SHYGQVQGQG-------QGSHHGQTDRQGQGSHHEQTDR---------
------QSQSSH----YGWTDR--QGQDSH-----YGQTDRQSQSFHYGQTDRQGQGSH-
------------------------------------------------------------
------------------------------------------------------------
-------------------YGQVEGQGQGSHHGQIDR-----------------------
-----------QSQSSHCGQT-DRQE----------------------------------
--NGQINRQGQSSHHGQ-TD-----------------------------I----------
---------------QGQSYHYGQTYKQEKDSHHGQTDRQGQGSHHEQTDRQSQSSHYGQ
TDR-QGQGSHYGQVEGQGQGSHHGQTDK--------------------------------
----------------QSQNSHYSQTGRQEK-----GSHYGQTDRQVQGSHYSQGDKQGQ
SLHH--GQTGRQGKGSHYGQTDIQGQGSHHEQTDRQEKGSHHGQTDRQGKSS--------
----------HYGQTDRQGQKSYCGQSQMAETEKHQQNTHFQGNGK-TR-----------
--R-DSYVEQSEKSRRLSQQIPGQEVN-QNQAHGFQSKQQH--SYHAWKP----EEDSQ-
-----------YHQHKLLAQI--QQERP--LYHKGSDRQSGNS-----------------
-------------------EQSHRQVETRQNQDK--------------------------
------------------------------------------------------------
--------------------------R---------------------------------
------------------------------------------------------------
----QSHQA------EEKQGHQ-----------------SWGEHSHEGQESAWEAQDRQT
CEEEQNHQTKNRQTYEDEQNHQ--------------------------------------
--RQNKQTWEEDQHHHQ-------------------------QQDRQIYEDEQNHQRRDR
QTHIED-------YNH--------------------------------------------
------------QQ----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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--------DSQTHEEKGRYQGSQD------------------------------------
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---QRRQQGEGHPSKAANNPPNPFYGYVQEQKSYQY------------------------
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-------------

----------------MSPLLRSVIDIAEVFDHYATHSCE-GASLSKKDLKNLLERELGD
VLQRPHD-----------PETVDVILELLDRDSNGRVDFN-----------E-F-L-L-F
-L---------------F-K-L-A-Q-A-C-Y--S-A-I-N-Q-A--I--G-L------D
E-KTA-L-P-R-E-K-R-SL-S--QD-RRQ-ED-Q-R-----------------------
-------------------------------RF-------------------------EP
RDVQRDEEPG-----RRSWQKRRE----QEE--RA-EEQSRR----------Q-------
---------------ER----------LEE-R------------------QQRRELQELE
E--R------------------------------------LAEKEPLKEQQR--------
-------------QE-------LRSREQREER----------------------------
--------------------------------------RLQQ------------------
------------------------------------L--R-------------D--PEL-
-----R------------------------------------------------------
------------------------------------------------------------
--------------------------RQQE------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------LVA---
---------------EE-DE---EQT---------------QL-----RE-PQTLTRRLQ
RQLESE-------------------------------AEARQNK---VYSR---------
PRR-QEPE-----------ERQLR------------------------------------
------------------------------------------------------------
-------------------EQEQRSRELQQQRAQEK-----EE-----------------
-------------------RLEQQ----------QQQRSQRRQAEEQR------------
------FR--EEEQQRAELQDS------LLE--ERQRRRQAER------RQ--LQEES--
-----------QRGRTLYA-------KP------SARQQKEEVLR-EERL-----LQEE-
--------------------AQQRRQRDRKYRQEEERL-QQEEEELRQE-----------
-------------------------EEQLR------------------------------
-----------------------REEEQLQR-------------------------EEER
------------------------------------------------------------
------------------------------------------------------------
LQKERRRLQQERQYRKESDVQREEE-----------------------------------
-------------------QLQREEERLQQQEERLRKERRRLQQERQ-------------
------------------------------------------------------------
------------------DRKENNL---QREEEQL---QRD-------------------
----------------------------------EEQLERRRLQQERQYQEENLQQEEER
LQQ-------------------------------EEGRLR---RE------RRRLQQERQ
Y------------------------------------QEEDLQRLRDEGQRRDLKW----
QWLPEKETEARGRRLFSKRREDGEQIRQLED-SLEHERPSRQDRRPLQDEAE-----EKR
ELEQERRRRQQRDRQFLEEEQ----LQRER---QREAARQGERLREEEQLLRD-LR---R
RPQERDGKFLEEERQLRKERE-----------------------ELRQRRE-ERQFQEEE
--------------------------------------PRHQELRQERDRKSREEQERRQ
QRR------------------EEEQLRE-EEQKFRREEEQRLQEL---------------
---------EEE--------------------QL--------------------------
--------------RRQERDRKLRRD----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------QERLQ-----ELEEEQLQDRKFPREQELRRDRKLRRE
EELR--------------------------------------------------------
--QELEEEQLRDRKLRVEEQLRREREAERQRVQERDRNFRREQEFRQELEDEQ-----PR
DRKFRREQELRRDRKL-------HEEEE--------------------------------
------------RLQELEEEQLRRQERDRKLHRKLRVEE-------------------QL
RREREAE-------------RQRGQERDRKFRREE-------------------------
-----------ELRRDRKLREEEELRQEL--QEEQLRRQERDRKFREQ------------
-------------------KEHRQER----------------------------------
--------------DQRFRGEPE-LRNEREGHQRRQQLR--FEEQQRRHQ----------
------------------------------------------------------------
------------------------------------------------------------
---------EREQQLRQERDREFREEKQER--QEREELQL----RRQKRDGQYQAEN---
-----------QFARDTIRRRQEQERRQEEERRRRQERERKFQEER-IRR----------
------------------------------QEEQRRRQALE-----TGTRQFANVPV---
-------------------RSSPLYEYIQEQRSQYRP-----------------------
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-------------

----------------MTNLLRSVVTVIDVFYKYTKQDGE-CGTLSKDELKELLEKEFRP
ILKNPDD-----------PDTVEVIMHMLDRDHDRRLDFT-----------E-FLL-M--
-V---------------F-K-L-A-M-A-C-NKV----LSK---E-YCK---A-------
SGSKKHRHHHR----------HQEEESETE-----------E-------ETLG-----QK
SGYRHSSWSEG-EEHGYS---SGGSRGTGKHRHGS-----------------------S-
-AWRLGRPG------------------------NLSSSGNQEGAE-KRYHGSTS------
---------------------------GHSWS--------S--GKERHGSSGSEELEERG
K--------------------------KSHV-------------SPSR----ES-----G
EEYESG-------------------SG---------------------------------
--------------------------------------------SQSQGRIGHGGLSHGL
ETS--GH-----E-SNST---------QSRRSKGKKLGSG--------------------
------------------------------------------------------------
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-------------

----------------MTNLLRSVVTIIDIFYEYTNQEGE-CDTLSKYELKELLGKELYP
ILKNPDD-----------PDTVDVIMHILDRDHDRRLDFT-----------E-FLL-M--
-V---------------F-K-L-V-M-S-C-NKI----LSK---E-YCK---A-------
SGSKKQRHVHR----------HQGEESETEE----------E-------ETMG-----HK
SGYRHSTWNEG-EEGGYS---SGDLSGNAKHGCGS-----------------------N-
-PRSLGRQG------------------------GLPSSGNLEGSE-KWHHGSSS------
---------------------------SLSWN--------I--GKERHGSSC-GEMGERR
N--------------------------KSSV-------------NSSS----ES-----E
EEYESS-------------------SG---------------------------------
--------------------------------------------SKRGRRRGHSAMSHGF
S-S--GH-----E-SNST---------QSRRGGEKELE-----ANSISSGDCGRKSYACG
FN---------------------------------------------------------N
SGGCGRH---QI---DCRSGQAGRFG------SCT-QSDCQSECGRGQGHGYFSGGQASG
YGK-----HEGVSCN-PSSGQIVYGS----------------------RACGQ--AQNC-
EGQQGKG--SSHSSCYGQC-----------------------------------------
-----------------------------------------------G-------S----
-GETQSYSYGQH-----------GCGAY-EHSYNSGPNSSGSSEFT--------------
---KC--------E--QHRFGSGQT------S-GCEQ-----------------------
---------------------------------------HGTGSR---------------
---HSSG---------FGQHGS---G-----------------SSHRYGQH---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------GPGSSQS-
------------FSFGQ-HGSGSCQSSSQH------------------------------
-RSGSGHSFGQHGSGSSQSSNFGQHG-----------SGSSQSSSFGQQGS---------
GSS------------------------------------Q--------------------
------------------SSSQH---G----------S------GSSQSSRFG-------
----------QH-GS-------GSS-----------------------------------
-----------------S-----GH-S-----S---------GPHGSSS-----------
------------------------------------------------------------
-SQSSSFGQ--QG---------------------SGSHQ--------------SSTQ---
-------------------------------HGSS-------------------------
---------------------------SGHSFGQH-----GS------------------
------------------GSSHSSS-----------------------------------
------------------------FGQHGSG------SSQSSS-----------------
--------------------HH----------------GPWSG-----------------
-------QSS-GQHESG-------------------------------------------
------------------------------------------------------------
----------------SSHSSSQQSSGSCQSSNVGQH-----------------------
-------GSGSSQSSS--QHGP-WS-G-QSSG---------Q-HGSGSGNSSSQHG-SGS
SQSSN-CGQHGSGSSQSSSQ-HGPW-------------------S---------------
GQS--SGSQGS------GSRQSSSFGQHGSGS----HQS----------STQHRSGSGHS
FGQHG-SGS-SH--SSSFG-QHG-SGSSQS---SSFGQQGSGS--SQSSSQHGP-W----
---------------LG----------Q----S-S-------------------------
------------------------------------------------------------
-------S--------------------------QH-GSG--------SS-QSSRF----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------GQHG--------SGSH-QSSTQ------H------
-------RSG------------SGHSFGQHGSGSSHSSSFGQHGS-GSS-QSS-SHHGTC
QH-GS-GS-SQSSNC-G-QHGS-GS-SQ-SSSQHG-PCSGHSFG-QHGSGSSHSSSFGQH
-GSGSHQSSTQHRSGSGHSFGQHGSGSSHSSSFGQHGSGSSQSSG--------Q------
-----------HESGSGH-SSSQHGSGSSQSSNVGQHGSGSSQS-SGQ--HGSGSG--HS
SSQHGSGSSQSSNCGQHGSGSSQSSSQHGPCSGHSSGSQ--GSGSRQSSSFGQH------
GSGSHQSSTQHRSGS--------GHSFGQ---HGSGS------------------S----
----------HSSSFGQHGSG---------SSQSSSH-----------------------
-HGPWS-----------GQS-----------SGQHESG----------------------
-SGHSSSQ------HGS----GSSQ----S------------------------------
----------------------------SNVG----------------QHGS-------G
S------SQSS-SQHG-PW-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------SG--Q
S-SGQ-H-----------GS-GSGHSS--SQHGS-GSSQSSNCGQHGS-GSSQ-SSSQ--
-------HGPC-SG--H-----------------------------------S--SG-SQ
GSGS---RQSSSFGQHGSGSHQSST--QH---RSG--------SGH-SFGQHGSG--SSH
SSSFGQHGSGSSQSSSHHGTWSGQS---SGQHESGSGHS--SSQHGSGSSQSSNVGQHGS
GSSQSSSQH-----GPWSGQSSGQHG--SGSGHSSSQHGSGSSQSSNCGQHGSGSSQSSS
QHGPCSGHSSGQARSGSSQSSSFGQHGSRSSHSSSQHRSGLTQSSSQHGSGSSQSSNVGQ
HGSGSSQSSSQHRPWSGQSSGQHRSGSGHFSSQHGSGSSQSSSQHGP--CSGHSSGQTES
GSSQSPSFGQHGSGSSHSSSFGQHGSGSSQSSSQHGPW---------SGQSSSQHGSSSS
QSSSFHQHVSGSSQSSSQQGSCSGQSSGQHGSGSGHSSSLGQHGSGSRQSSSQYESC---
SHQSSSQ----HGSGPSHSSSFGQYGTSSHQSS---------------------------
------------------NSGQHRSGSGRS----------------------SGLEQHES
RSGSGQSFGCGQQASGSAQSSYSQPDSPSR------------------------------
-------Q----------------------------------------------------
-----------------------SPSIGSSSWQASSSGQHGSFSHHS-------------
---SGYSQPELSSGQSS-------GYSQTESDITEQESSGPHSDKRHPKRGRPKSGSESE
GHKRIQGHSQQRCGSSQEGTAS--SRTRRQEIRHSQSSDSEWHSGISQGHS--GSTYGQA
GSQHDDLGS--SSTGRHRTSHEQSGDTTIH----AQY---DEGQSKQSGSSTPGRRE-SS
HSEFSDSELHS-----------------------------------------GVSQRHSG
STHSQAGSPHGNSGSSNTGKEGTSHGHSGDTTRHA---------------------RYGY
RQSINSGSSTTGRRESNHRQSHDSEGHSGISERHS--AVFHGQYGSAQKQSVSNTTRRHE
SHNKHS-------------------------------------------------GDSSK
YSASGQ------------RQTYTHG-----QSGRQGSTHGQIGDESI-------YSGSAH
GQTTSTHGQPGSSTTERHESGHAQAHVSHRQSRATETHRFYGHGRST--SVTSKTCPRKF
TVHSDYYPSEYTQSLSHIHTH-----THKEAKYDTAHQERGPSREGRQTHVHGQSQDNAR
HAGQAATTGQREPSWGHSQSDT--------------------------------------
GRS---------------------------------------------------------
---------------PQSQQEHSGRSSRHPAHGHGPSTAPV----QPGRPGRSSQSQESD
SEGHSEDWQAHAREDRRKEEESE----NERRGRK--------------------------
SGSGSRSPSHPR---HSSRTSGDPQGPQAHHRQYDTAHQERGPSREGRQTHVHGQSQDNA
R-----------------------------------------------------------
------------------------------------------------------------
-------------------------HAGQAATTGQ----REPSWGHSQSDTGRSPQSQQE
HSGRSSRHPAH--GHGPST---APVQPGRPGRSSQSQESDSEGH--SEDWQAQSEPR---
-----SEHQHGVAHGEARDSSAHSAPHGGHGAHHGWSDSASGRP----GSQAEGRQGSHQ
GHSGDSARHSGPGHQQSP------------------------------------------
--WASDLQMHRGPSAIQESDAEQHSHHSHT-----------------------------Q
QAHHGQSDSAHQEPGSIREGRQAYRHGHSQDNARHAVQAASPGQREPSWGHSQSDTGRSP
QSQQEHSGRSSRHPAHGHGPSTTPPMPGRPGRSTQSQESDSEGYSKDWQAQSESGSEHQQ
GAAHGQARDSSAHSAPHGGHGAQHGWSDSASGRPGSQAAGRQGSHHNPNRSTRESDSEGH
SEDWQAQYESRSEHQHGAAHGQTRDSSAHSALHGAHGAQHGWSESASGRPGSQAAGRQAS
RQGHSPDGSRPSGSCHG-------------------------------------------
------------------------------GPTSHQNPQSSHTAPTPSTGGRPESHRQHS
GDSATHSGPGH---------------QQSPWA-SDPQMQRGPTAMPESDAEQHSHHSDTQ
SGSGSGS------HPTSSLSHPRHSSR---------------------------------
-----------------------------------------PSGDPQGPQAHHGQTDSAH
RESGSIRGGRQAHGHGQSQDNARHAGHAPSPGQREPS----WEHSQSDTG----RS---P
QSQQE-HSGRS-------SRHPAHGHGS--------------------------------
-----MTTPPMPGRPGRSRQSQESDSEGHSE---------------D-------------
----------------------WQAQSESRSEHQHGAAHGQARDSSAHSAPHGAHGAQHG
WSDSASGRPGSQAAGRQGSRQGHSPDGSRPSGSRH-------------------------
-----------------------------------------ESDVEQHSHHSNTQSGSGS
GSHPTSSLSHPRHSCRPSGDPQGPQAHHGQSDSAKRESG----SIRGGRQAHVHGQSQDN
ARHAGQAASEHSG---RSS--RHPA------------------------HGHGSMTTPPM
P----GRPGRSSQS----QESDSEGHSEDWQAQYESRSEHQHG-----------------
---------------------------------------------AAHG-QTRDS-----
----SAHSA-LHGAHGAQHGHSPDGSRP-------SGSRH---G-----------RPTSH
QNPQSSHTAPTPSTGGRPESHRQHSGDSATHSGPGHQQ----------------------
-----SPWASDPQMQRGPTAMPE--SDAEQHSHHSDTQSGSGSGSHPTSSLSHPRHSSRP
SGDPQGPQAHHGQ---------------------------------------------TD
SAHRESG--SIRGGRQAHGHGQSQDNARHAGHAPSPGQREPSWEHS---QS--------D
TGRS---PQSQ-----------QEHSGRSSRHPAHGHG----------------------
------SMTT--------------------------------------------------
------------------------------------------------------------
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-------------

----------------MPQLLQNINGIIEAFGRYARTEGS-CTVLSHGELKRLLEHEFAD
VIVKPHD-----------PATVDEVLRLLDEDDTGTVEFK-----------E-FLV-L--
-V---------------F-K-V-A-Q-A-C-FKT----MSKSP-AGACV---S-----QE
SGSL-----PS-G----ASQELGK-EQSRRAEV--GQAREGQHREG--------------
-------SQ-------------------------------------------------CG
QSTQA-----------SRGQAG---------------AGAQIYG----------------
------------------------QDLG------QDR------------------QSESQ
RQERE-SQQTQAGGHVQQTLRVGEDKIHQTRQ------R--------------E-----S
ERQS-----QTREQDRTHQISETV-TGTG-------------------------------
--------------------------------------------TQNQT--YATQTVEQN
RSHHIGSPGTQPQESTHGQTRET----------------E--------------------
-----VQNQDRSQTSQ-----TVTREHFQTP-------------GGA-----TQAVE---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------QAIQQGRSH----------------QIGSPGTQPQESTHGQTRGTEVQGQNRC
Q---------------TSEVVT---GE--HI----------QTQAGSQTQTH--------
-IQTM------------------------------------E------------------
------------------------------------------------------------
----------------------QDRSQTASHIGDRD------------------------
---------------------------------------------------EGQTQ----
RQSGRGHRWTQVSHYEA-GE----------------------------------------
---------RKLE-------------------------GQAQAGASTLTGRQDWSTTHPR
YSV----------TGGQG-----------------------EREHT--------------
-------VVTQEWVDDHTREM---GVPRQDQSS----LYT--------------------
------------------GMHSAQGQEAAQ------------PG-GKRGLT-AMG-----
----------L--------------------------YSYFKSNNP--------------
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-------------

----------------MPRLLRDVLCVIETFHKYASEDSN-QTTLTGRELKQLLQGEFGD
FLQPCV------------LHAVEKNLNLLHIDSNYIISFD-----------E-FVL-A--
-I---------------F-N-L-L-N-L-C-YLD----IQS-----LLS---S-KLRQ--
-VTKP-EKEKPDD------VDLQTAT---GD---------AQWTAG---TSPT-------
-----------QEER----------------MLPS----------------------GMA
FSSQLMPEES----------------GAVGNNRVD-PWREAKTHNFPGEASEHNDP----
---KNQHL-------------------------------------------------EGG
-------EQSQEVAQYVPTTEDNEGQ-LKTKK---PMEGSKQTSSPTE-RKG-QDKEIPR
ERD-EP----ARGQSVS------KIRDQF---------------GEQEGNLG--------
--------------------------------------------TQSSPAQEATQRPYE-
-----------------DQ----------EVSIEK-E--K----------HSNTQEPPQ-
------Q------------------GEDE-P-------------NSEHA---DMP-----
EEAAARKPSQTQ---KSTDPEDI--CRT----FDNQEPEKDAD------------QIPAE
------------TKN--SGETEDYGR---------------------TSEAQE-------
------------------------------------------------------------
------------------------------------------------------------
------------------KECETKDLQDQGDHRNG----SESSDMR--------DERKER
RGPETHGTAGQ-KE--------------------HDR---------------------KT
QPQVL-------------QTQTQDGKY--QELQGLS-------KSKDAEKGSET------
-----------------------------------------QYLSSEGGDQT-----HPE
L--------------E-------GA----A-VSGEDAEHTEEGTAEAFVNSKNAPAAERT
LEAKE----------KTRD-----------------------------------------
--------------------------------------------LAPLEK-QSAGENGRV
TKTHDK--PVEEEDGYQ-----------------------------------REDPEAAI
TQNDEGSSETLNSLASEEGNSSSKTG---------------E------------------
--------LPMQGDSQ------------------SQRYPHGKSG---------QEGHNNN
PST---------------------------------------------------------
------------------------------------------------------------
---------------------------------------------QRQGTSGEKNRAQEA
V------VLAVR------------------------------------------------
-GEDTQLTEDREQPAREKHK-S--------QGSG-----T-KGPGAAVEPNGHPEAQ---
---ESTVGD--ENRKSLEIEITGALDED--FTEQLSLMQLPGKGE---------------
-------------------SRNKLKVQGPSSKEEKGRAPEAKDTLLKRLDEDTSASP---
--QIQLEREE-------PVTL-EEEDEGPQELAGDGDNQQSPIKK-EHNSSVSWSSLKKQ
MQRVQESSSVEKSTVHSSPLYQYLQQKILQETNINQE--------------------EHQ
K---------------------------------QVQIAQASGPG---------LCS---
-VSLTSEMSDCSVFFNYSQASQ---------------PYTRELPLDESPAGAQETPAPQA
LEVKQGHA-RERLVPQREASTT----------------------------------K---
-----------------------------Q------------------------------
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-------------

----------------MPRLLRDVLCVIETFHKYSGEDGD-GATLTRRELRQLLQGEFGD
FLQPYV------------LHAVERNLNLLDIDAEGATSFD-----------E-FVL-A--
-V---------------F-N-L-F-N-L-C-YLD----IQS-----LLS---L-KLKQ--
-ISKP-EKEKPGD------VYLQETT---RN---------GQETVG---ILPT-------
-----------QEKL----------------MLPS----------------------GMA
SSYQLSPEEN----------------GAVGHNRVD-PQGDAKTHNLQGEASEHNDP----
---KNQHL-------------------------------------------------EGD
-------EQSPEVAQDVAATEDNGAQ-LKTNK---PMAVSKQTSSATE-GEA-QDKEIPR
EGD-EP----AREQGGT------KTRDQF---------------GEQEGNLG--------
--------------------------------------------TQSSPPEEATHRPYE-
-----------------DH----------EVRAEK-GIKK----------YSKTQEPAL-
------Q-------------------EEE-S-------------SSEHA---GLP-----
EKAAARKPSQTQ---KSTDPEDDNGSRT----FESQEPGKDAD------------RTPPE
------------TKS--PDEPEDYGR---------------------ISETQESSAHK--
------------------------------------------------------------
------------------------------------------------------------
------------------KEHETKDLTVHGGSRNV----SETPDMR--------AERKEG
NGPEAHGTAGQ-KE--------------------SDR---------------------KT
QPPAL-------------ESQTQDGKY--QELQGSS-------KGKDAEKGSET------
-----------------------------------------QDLSSEGGEQS-----HPE
I--------------E-------GA----E-DPGEEARLTEEGTAEAFLNRKNGPAAEGT
PGARE----------RTQE-----------------------------------------
--------------------------------------------SAPLEN-QSEGGNSTV
TNTHDR--PIKEDDCYQ-----------------------------------RENPESPV
TQNDEESSETPNSLAPEKSNNSSETG---------------E------------------
--------LPIQGDSQ------------------SQVDLHGESA---------QGGHN-N
PDI---------------------------------------------------------
------------------------------------------------------------
---------------------------------------------QKQGAPGKRNRAQEA
V------VLALR------------------------------------------------
-GEDVQLTEEQEQPAKVEHK-S--------QGSG-----T-KGPGAAVEPDGHPEAQ---
---ESRVGG--ENRKSPMTEIPGALDAD--FPEQLSQVQFPEKGD---------------
-------------------SKNKLHGQSPSTKDEEGEAPEAQDALLKSVDEDNSASP---
--KTHFGLEE-------PVTL-EEKDESLQELAEEGDDQQIPVKKEYS---------SSR
MQKDQDPCSVERSAVHSTLLYHYLQEKVLQQTNITQE--------------------KDQ
N---------------------------------QAQTARASGPE---------ICNDQS
RASVTGETSDCPVFFNHSQASQ---------------QYSRNLLPKEAPAGAQQTSVP--
------------------------------------------------------------
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-------------

----------------MSPLLKCIFDITETFNQYASHDCD-GAALSKKDLKNLLEREFGD
VLRXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-----------X-X-X-X-X
-X-X-X-X-X-X-X-XXXXX-XXX-XXX-XXX-XX-XXX-XXX-XXXX-XX-X-----XX
X-XXX-X-X-X-X-X-X-XX-X-XXX-XXXXXX-X-X---XX-X-X--X-X-X-X-X-X-
-X-X-X-X-X---X-X-X--X-X-X--X-XXXX-------------------------XX
XXXXXXXXXX-----XXXXXXXXX----XXXXXXX-XXXXXXXXXXXX-XXXXXXX----
-------------XXXX---------XXXXXX------------------X-XXXXXXXX
X--X----------------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXX----XXXXXXXXXXXXXXXXXXXXXXXXXXX---XXRERR-EQARARG------
-------------E---------------------QEVALTM------------------
-----------------------------QLRQQE-RELE-------------E--PRL-
-----GQELRR-AQ----------------------------------------------
------------------------------------------------------------
------------------------------ETREQQLRRREEER----RE----------
--------------------------------PEQRRERQLRRELEEERR-EQELR----
R-EQEPRREQ---ELRRQEERREL--ELRREQELRRELEEETRGQELRRQEERREQ--EL
RREREPRRQ--------------------------------------EQ----RREQELR
RELEE--------E--RR------------------------EQEPRRQ-----------
----------EERREQELRRQ---------------------------------------
-------------------------------------------------------LEEGR
REQELRREEVQR---------------------------RQEQGSEQELRRQEEERRELE
-------------------------------------------------------LR---
-------------------------REQELRRQEEE------RRQEPGLQEL--------
----------RGEQELRRD----------------LAAERRE-QARRGERGQRRELP---
---------------EE-EV---EQE---------------RA-----RELGERSAPRWQ
WQLESE-------------------------------VEARQSK---VYPP---------
RRQ-EEQR-----LREQLEEQRRR------QE-------REQR-----------------
---------------------------------------------------LR-------
----------EREEQARQQDAEEPRRAFKWQREAEE-----ESQRHRQRLS---------
-----AR-PLS----QRQLRAEER----------LERE-LLLEEEEQRRQR----LERSG
REEEQQLPEEEERLQRLERARQLQEEEERLQEERERRRRQEQRGDQKLRWQ--LEEES--
-Q---------RRRQALYA-------KP------ARRELLREEEL----L-----QREE-
-----------------------------------ELL-QREGELLQR------------
------------------------------------------------------------
------------ERRRLERERQYR------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------EEELQQEEEV-----------------------------------
---------------------Q--------------------------------------
------------------------------------------------------------
---------------------------------------REE------------------
-------------------------------------LER--------------------
----------------------------------------------------RRQARERQ
L-------------------------------EEELQRRDR-QRLFGEEDRSDLKW----
QWQPEKEKEARDNRLYSKRKENEETIRQLED-LQARERQFLQDEQEY-------------
----ERERGEQRDQQLQEEQL----LREERE--ERRRRQEDRQFLEVEQELRQ-ERDQQL
RSQERDRRFFREEQQMREEQE---------------------EQQQLRRQEREQQFRQEH
DRK---------------LGQ--EAQIQEREEQQLRRREREQELRQERDRKFREEERELQ
RER------------------EQQLRRQERDRQFLQEEQLQEREE-------QQ------
------------------------L-----------------------------------
------QQEREEQLLRQERDRKFREEEQELRREREQQLRRQERDRQFLQEEQQQLRQERE
EQLLRQERDRKFREEEQELRREREQQLRRQERDQQLRQE---------------------
------------------------------------------------------------
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-------------

----------------MTDLLRSVVTVIDIFYKYTKQDGE-CGTLSKDELKELLEKEFRP
ILKNPDD-----------PDTVEVIMHMLDRDHDRRLDFT-----------E-FLL-M--
-V---------------F-K-L-A-M-A-C-NKV----LSK---E-YCK---A-------
SGSKKRRHGHQ----------HRKEESETEE----------E-------ETPR-----QK
SGFRHSSWSEG-EEHGHS---SGGSWGTEKRRHGS-----------------------N-
-SRRLGRQG------------------------ELSSSEE---AG-ETHSGSSS------
---------------------------GHSWS--------S--SKERHGSSS-EELGKRR
N--------------------------KSQG-------------SPSR----ES-----G
EEYESG-------------------PR---------------------------------
--------------------------------------------SKSQERKGHGGSSHGL
ETS--KH-----E-SNST---------QSKGG-GQKLGPT-----SASSGKNKAQSHSCG
SS---------------------------------------------------------N
PGRSGRP---QN---ASHSCQTSRSEGQGNQSCCS-HSGCQTGSSGGQGFGCVSGGQSSR
CCQ-----PEPRSCS-HSSSQRGSGS----------------------KQCGQ--SQNC-
GRQQRTG--SSQSSCCGQY-----------------------------------------
-----------------------------------------------G-------S----
-GASQSSGYSQH-----------GTASC-GHSSSSQQR--GCGEFT--------------
---QC--------G--QHWPGSGQS------S-CCEQ-----------------------
---------------------------------------HGTSS----S-----------
---HSSG---------CRQHGH---GS----------------GQSCCGHH---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------GSASSQS-
------------SGYGQ-HGSSSGQ-----------------------------------
-----SCGFGQHGSSSGQSCGSGQHG-----------YGSSQWSGSG-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------QH-----GS------------------
------------------SSGQSCG-----------------------------------
------------------------SGQQGSG------SGQSCG-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------SGQH-----------------------
-------GSGSSQVSGSGQHKS-VS-G-QSS-------------------GLGQHG-SGS
SQWSG-SGQHS-------------------------------------------------
------------------SGS-------GQSS----GQS----------S---------G
FGQHG-SGS-GQ--WSGSG-QHA-SGSGQS---SSSRQHKSTS--GQSS-----------
--------------------------------G-F-------------------------
------------------------------------------------------------
-------G--------------------------QH-GW--------------SGS----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------GQHG--------SGSG-QSSSS--GQHKS------
-------TSG------------QSSGFGQHSSGSGQWSGSGHHSS-GSG-QSS-GF---G
QH-SS-GS-GQWSGS-G-QHGS-GS-GQ-SS----------SSG-QH-------------
-KSTSGQ---------SSGFGQHSSGSGQWSGSRQHGSGSGQWSG--------SG-----
-----------------------------------HHSSGSGQS-SGFGQHSSGSGQSSG
FGQHSSGSGQSSGFGQHSSGS------------------------GQSSGFGQH------
SSGSGQS-----------------SGFGQ---HSSGS------------------G----
----------QSSGFGQHSSG---------SGQSSG------------------------
------------------------------------------------------------
-----FGQ------HSS----GSGQ----S------------------------------
----------------------------SGFG----------------QHSS--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------GSGQWS---------------------------------
---GSGQHSSG-SG--Q--SSGF-GH-------------HSS---GS---GQWSGSG-QH
SSGSG---QSSGFGQHGSGSGQWSGSGQHS-SGSG--------QSS-GFGQHSSG--SGQ
WSGTRQHGSGSGQWSG------------SGQHSSGSGQSSGFGQHGSGSGQSSGFGQHGS
GSGQWSGSR--------------QHSSGSGH-SGFQQHGSS-------------SGQ---
-------------------SSGLGQHRSGSGQW---------SGSSQHSSGSGQSPQ---
------------------------------------------------------------
-------------------------------------------------------RQS--
--GDTSRQ------PQAGHG---------------QPSHSGSSPI-RRT-PVHSESSQGE
EHSGVSH----RHWGSSQGQGGSQHGESGSS-----------------------------
------------------PSHS--------------------------------------
-----------GSSPIRRTPVHSESSQGEEHSGVSHR---------HWG-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------SSQGQG
GSQHGESGS--SARGRQRSPQRQSGDTSRQ----PQA---GHGQPSHSGSSPI-RRT-PV
HSESSQGEEHS-----------------------------------------GVSHRHWG
SSQGQGGSQHGESGSSARGRQRSPQRQSGDTSRQP---------------------QAGH
GQPSHSGSSP-IRRTPVHSESSQGEEHSGVSHRHW--GSSQGQGGSQHGESGSSARGRQR
SPQRQS-------------------------------------------------GDTSR
QPQAG---------------HGQPSHSGSSPI-RRTP-----------------------
------------------------------------------------------------
-VHSESSQGEEHSGVSHRHWG-----S-SQGQGGSQHGESGSSARGRQRSPQRQSGDTSR
QPQA----GHGQP-------------------------S---------------------
------------------------------------------------------------
--------------------------------------HSG----SSPIRRTPVHSESSQ
GEEHSGVSHRH-------------------------------------------------
--------------------------WGSSQGQGGSQHGESGSSARGRQRSPQRQSGDTS
RQPQAGHGQPSHSGSSP-----------------------------------------I-
------------------------------------------------------------
------------------------------------------------------------
-----------------------------RRTPVHSESSQGEEH--SGVSHRHWGS----
-------------------------------SQG-QGGSQHGES----GSSARGRQRSPQ
RQSGDTSRQPQAG-----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------H---------------GQPSHSGSS-PIRRTPVHSESSQGEEHSGVSHRH
W-----------------------------------------------------------
-------------------------------------------------GSSQGQGGSQH
GESGSSARGRQRSPQRQSGDTSRQPQAGHGQPSHSG-----SSPIR--------------
------------------------------------------------------------
--------------RT-PVHSESSQGEEHSE-ISHR------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------HWGSSQGQSGSQHGEYS----STHLSPQ-RQSGQSS--
HVHG-----Q-----------S--GTKHFQSP--SSSNQKYDSYKHWR---HGSYGREE-
-------------------------------YYYGQTGYGPSGHSRSS--SRNSSPLRSV
RSATDKQVSRQRHISIFDHTGS--KTTGE---TKG-LVLTYGETDMGHG-ESADSHNQFE
SSAVRRQMS-SRGQSAVASAQSGDAEVI-------SGYT---------------------
---VSRKRET-------------NQSQSADESGSGHSQDMSFHVQSESSS----------
------------------------------------------------------------
------------------------------------------------------------
-ARNQSG--FSAHVRQVDSSRQSSDSYQQPSDRRSRNQRSFSSN------S--------L
--------------------HSQ---DCSETEECRYLSS---------------------
-ITTSRPIRIYSQDAGD-------------RETRGSGATGYHGERNINSGSFSLDSNTPL
--YEYV--------------------QEQRCYY-----------FE--------------
------------------------------------------------------------
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-------------

----------------MAQLLNSILSVIDIFHKYAKGNGD-CALLCKEELKQLLLAEFGD
ILQRPND-----------PETVETILNLLDQDRDGHIDFH-----------E-YLL-L--
-V---------------F-Q-L-V-Q-A-C-YHK----LDN---K-SHG---G-------
RTSQ-QERGQE-G-----AQDRKFPGN-TGR---QH----RQRHEEERQ-----------
-NSHHS-QPERQDRD---------------SH--------------------------HG
QPERQDRDS--HH-GQSEKQDRDSHHSQP---------------ERQDRDSHQNQSERQD
KDFSFDQSERQ------------SQDSS--------SGKK---VSHK--STS--GQAKWQ
G--HI-------F-------------ALNRCE------KP------IQ-----------D
SHYGQ-------------------------------------------------------
---------------SE---------------------------RLTQ-Q----------
------------------------------------------------------------
----------------------S-----ETLGQASHFNQTNQQKSGSYC---GQSERLGQ
ELGCGQTDRQG---QSSHYGQTDRQD-Q--S------Y-----------HYGQTDRQGQS
-------------------S--HYS-------------------------------QM--
---DR----QGQSSHYSQPDRQG-------------------------------------
------------------------------------------------------------
-----------------------------------------------QSSH---------
------YGKMDRQG---QCYHYDQTNRQGQGSHY-SQTDRQGQSSHY-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------GQPDRQGQ
SSHY--GQMDRQGQSSHYGQTDRQGQSSHYGQTDRQGQSYHYGQTDRQGQSS--------
----------HYIQSQT---------G---EI--QGQNKYFQGTEG-TR-----------
--K-ASYVEQSGRSGRLSQQTPGQEGY-QNQGQRFQSRDSQQNGHQVWEP----EEDSQ-
-----------HHQHKLLAQI--QQERP--LCHKGRDWQSCSS-----------------
-------------------EQGHRQAQTRQSHGE--------------------------
------------------------------------------------------------
--------------------------G---------------------------------
------------------------------------------------------------
----LSHWA------EEEQGHQ-----------------TWDRHSHESQEGPCGTQDRRT
HEDEQNHQRRDRQTHEHEQSHQ--------------------------------------
--RRDRQTHEDKQNR-Q-------------------------RRDRQTHEDEQNHQRR--
------------------------------------------------------------
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-------------

----------------MSRLLRGIFCVIEIFHKYASEDGNKEAMLTHRELRQLLEGEIGD
FLQPHV------------FHAVERKLNLLHFDRDGTISFE-----------E-FLL-A--
-I---------------F-S-L-L-N-P-P-YFD----I-S-----LLN---S-EPRL--
-MSKS-EK--TDA------VDLGAIT---GS---------TQRVVG---VGPT-------
-----------QERL----------------IFPP----------------------EMS
LSDQSRKEEG----------------EAGDELMVS-PWEDVKTHGLPRNVSEPNDP----
---EKHQP-------------------------------------------------KED
---------AQEIAQTVPAAEYDVVQ-YQRNT---AVEVSKQSAGPTQ--------EIPR
QGN-KT----SRRQSDT------KISDYV-------------------------------
-----------------------------------------------------IQRPTD-
-----------------YE------------------EHA-----------SATQDPIL-
------Q------------------KEDKVA-------------GSAHT---DLP-----
VVAATGKSSQTQ---EVLEPTDD--TRL----SETQGTGKDAG------------RMPPE
------------TTH--LEEPKADAS---------------------ASGSHSLPVQE--
------------------------------------------------------------
------------------------------------------------------------
------------------REH------VQSRSRNV----SETSSRG--------D-----
------LEEEC-KE--------------------HER---------------------KT
RSLAP-------------EAETPDEKC--QEFPGSQ-------RENDVERGTAA------
-----------------------------------------LDPSSGEGNQN-----LPE
V--------------K-------EE----S-ISEKKARHSEKDTVDTFAINKTSPAIEET
PETRE----------RSQE-----------------------------------------
--------------------------------------------LAPLEE-QSQGKQHRA
AKTHDE--SVRKEDHSE-----------------------------------GEDPELSP
TQSDEGFCETPNSLAPEVGKSSSEIA---------------E------------------
--------TRVPGESQ------------------RQVEHHGDAK---------QESHINN
PDS---------------------------------------------------------
------------------------------------------------------------
---------------------------------------------QKQGVPGESNREQEE
V------VLSIQ------------------------------------------------
--EDGQLPEEQEEEE---RSDS--------LSSR-----TKRGPGELWSPVKKGTPQ---
---QG------VKTKSLEAEGSEAQ-----------------------------------
------------------------------------------------------------
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-------------

----------------MTDLLRSVVTVIDVFYKYTKQDEE-CGTLSKDELKELLEKEFRP
ILKNPDD-----------PDTVDVIMHMLDQDHDRRLDFT-----------E-FLL-M--
-V---------------F-K-L-A-L-A-C-NKV----LSK---E-YCK---A-------
SGSKKHRHGHR----------HQEEESETEEN--------EE-------DTPG-----HK
SGYRHSSWSEG-EEHGYS---SGGSRGTVKRRHGS-----------------------N-
-SRRLGRQG------------------------NLSSSGNQERAE-KRHHRSSS------
---------------------------GHSWS--------S--GKERHGSSS-GELGERI
S--------------------------KSHV-------------SPSR----ES-----G
EEYESG-------------------CG---------------------------------
--------------------------------------------SKSWGRKGHGGLSHGL
ETS--QH-----E-SNST---------QSRSR-GQKLESN-----CSGSGGSGRRSYACG
YS---------------------------------------------------------N
SGGCGRP---QT---ASSSCQSHRFGGQGYQSSCI-QSGYQSEINGGQGHGCVSGGQPSG
CGQ-----PESNSCG-QSYSQRGYGA----------------------REYGQ--PQNC-
GGQQRTG--TSQSS-CGQY-----------------------------------------
-----------------------------------------------G-------S----
-GGSQSCSNGQH-----------EYGSC-GHFSNSSS----SNEFS--------------
---KC--------G--QHGSGSDQS------T-SCEQ-----------------------
---------------------------------------HGTGL----S-----------
---QSSG---------FEQHVS---G-----------------SGQTCGQH---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------GSRSSQS-
------------SGYDQ-HEYSSGQ-----------------------------------
-----TSGFGQHGSGSGLSS--GQCG-----------SGSGQLSGYGQHGS---------
G-----------------------------------------------------------
-------------SHQSSGFGQH---G----------S------GSG-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------QSPGFGQHES-RS-G-QSN--------------------YGQHG-SGS
SQSFG-YGQHG-------------------------------------------------
------------------SRQTTGFGQHGLGS----GQS----------A---------G
FGQYG-SGS-GQ--SSGFG-QHE-SGSGQS---SSFGQHESRS--GHS------------
--------------------------------S-Y-------------------------
------------------------------------------------------------
-------G--------------------------QH-GFG--------SS-QSSGY----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------GQHG--------PSSG-QTSGF--GQHES------
-------GSG------------QYSGLGQHGSGSGQSSAFE-QGS-GSG-QSS-GF---G
QH-ES-RS-SQ-SRY-G-QHGT-GS-SQ-SS----------GYG-Q-------------H
-GASSGQ---------TSGFGQYGSGSGQSSGFGQHGSGTGQSSG--------FG-----
----------QHEYRSGQSSYGQHGTGLSQSSGYGQHGSSSGQT-SGFGQHG--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------S----SSGQ----S------------------------------
----------------------------SGF----------------------------G
Q------HGS--------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---GS-G-----------QS-S-----AFGQHQS-RSSQSS-YGQHSS-GSSQ-SS-G--
----YGQHESS-SG--Q--TSGF-GH-------------Q-S---SS---GQYCGFG-QH
GSGSG---QSSGFGQHETGSGQSSGFGQHE-SRSC--------QS--SYGQHDSS--SSQ
SSGYGQHGLSSGQTSG------------FGQHRTGSGQSSGFGQYGSGSGQSSGFGQHGS
GTGRSSGFG--------------QHEHRSGQ-SSYGQHGTGSSQSSGYSQYGSGSDA---
-------------------NTGFGQHESGSGHF---------SSSRQHISGSGQSTR---
------------------------------------------------------------
-------FGQYGSGSGQSTGLGQSVSRQGESGSTVH------------SRQETTHGRT--
--VDTTRH------GQSGHG---------------QSTQIGSRTTRRRR-SSQSENNDSD
MHSRVSQ----RHTEHAHTQVGSHFPESGST-----------------------------
------------------VHRRQRTTHGQT-----------------------GDTTRYG
QSGHGQATQTGSRTTGRRRSGHSESSDSEVHSGVCLL---------YTS-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------RCVETAHGQA
GSQHGESGS--TVQGRQGTTHG--------------------------------------
------------------------------------------------------------
--------------------------QTGDSTRHG---------------------QSGH
GQSTQTGSRTTGRQRSSHTEATDSEVHSGVSHRPHSREHTQGQARTQQGESESTVQGRHR
TTHGHT-------------------------------------------------GDATG
HAHSG---------------YGQVTQRGSRTTGSRGS-----------------------
------------------------------------------------------------
-GHSESSDSEVHSGVSHTHSG-----H-THGQAGSQRGESESTVHETHRNTHGQTGDSTR
HGQS----GHGQS-------------------------T-QTGSRTTGRQR-SSHSESSD
SEVH-----------------------------SGASHTHSGHTHGQAGSQH------GE
SGS------TVHWRQGT-THGQIGDSTRHGQSGHGHSTQT--GSRTTG-RQRSSHTEATD
SEVHSEVSHRP-------------------------------------------------
------------------------HSREHTQGQAGSQHGELESTVQGRHRTTHGHTGDAT
GHAHSGYGQDTQSGSRT-----------------------------------------TG
SSGSDHSESSDSEV----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------HS-AVSH--
---------------THSGH----------------------------------------
--THGQAGSQHGESG---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------STVHGTHRTTHEQTGDSTRH-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------GQSGH---------------GQSTQTGSRTPGRRGSGHSESSDSEVHSGASHTH
S-----------------------------------------------------------
-------------------------------------------------GHTHRQPGSQH
GESG--------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------SIVHRRWETTHGQTGDS
TRHGYSGHGQSIQAGSRST--R---RSPFQSH--SSERQRHGSSQAWK---HGSYGSAE-
-------------------------------YDYGHTGYGPSGD-SRQ-SSQNSCPAWSI
DSTANK--QLSRH-----------------------------------------------
------------------------------------------------------------
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-------------

----------------MPQLLRHINGIIEAFRRYARTEGS-CTALTRGELKRLLEQEFAD
VIVKPHD-----------PATVDEVLRLLDEDDTGTVEFK-----------E-FLV-L--
-V---------------F-K-V-A-Q-A-C-FKT----LSESP-EGACS---S-----QE
SGSF-----HS-G----AWQELSE-GQRSGTEV--GRAGKGQHYEG--------------
-------SS-------------------------------------------------HG
QSKQP-----------SRGQSR---------------PGAQTQG----------------
------------------------QATGSAWVSSYDR------------------QAESQ
SQERT-SPQIQRSGHTEQTQRAGEGKRHQTTQ------M--------------R-----P
ERQP-----QTREQDRAHQTSETV-TGSG-------------------------------
--------------------------------------------TQTQA--GATQTVEQD
SSHQTGRTSSQTQEATNDQNRGI----------------E--------------------
-----IHGQGRSQASQ-----AVTGGHAQIQ-------------A---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------GTHT-----------------------------------------------
------------------------------------------------------------
---QTPTQTVEQDSSH----------------QTESTSTQTQGSTNDQNRGTEIQGQGGS
Q---------------TSQAVA---GG--HA----------QTQAGSHTQTV--------
-----------------------------------------E------------------
------------------------------------------------------------
----------------------QDRSQTVSHGGAGE------------------------
---------------------------------------------------QGQTQ----
TQPGSGQKWTQVSNPEA-GE----------------------------------------
---------TVPG-------------------------GQAQTGASTESGRQEWSSTHPR
HNV----------TEGQG-----------------------DIQPT--------------
-------VVGEEWVDDHSRET---AIFRLDQGN----LHT--------------------
------------------SVSSAQGQDAAQ------------PE-EKQGIT-ARE-----
----------L--------------------------YSYLRSNKP--------------
------------------------------------------------------------
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-------------

----------------MPQLLRNINGIIEAFRRYARTEGS-CTALTRGELKRLLEQEFAD
VIVKPHD-----------PATVDEVLRLLDEDHTGTVEFQ-----------E-FLV-L--
-V---------------F-K-V-A-Q-A-C-FKT----LSESP-EEACS---S-----QE
SGSL-----HS-G----AWQELSE-GQRSGTEV--GRAGKGQHYEG--------------
-------SS-------------------------------------------------HG
QSKQP-----------SRGQSR---------------PGAQTQG----------------
------------------------QATGSAWVSSYDR------------------QAESQ
SQERT-SPQIQRSGHTEQTQRAGEGKRHQTTQ------M--------------R-----P
ERQP-----QTREQDRAHQTSETV-TGSG-------------------------------
--------------------------------------------TQTQA--GATQTVEQD
SSHQTGRTSSQTQEATNDQNRGI----------------E--------------------
-----IHGQGRSQASQ-----AVTGGHAQIQ-------------A---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------GTHT-----------------------------------------------
------------------------------------------------------------
---QTPTQTVEQDSGH----------------QTESTSTQTQGSTNDQNRGTEIQGQGGS
Q---------------TSQAVV---GG--HA----------QTQAGSHTQTV--------
-----------------------------------------E------------------
------------------------------------------------------------
----------------------QDRSQTVSHGGAGE------------------------
---------------------------------------------------QGQTQ----
TQPGSGQKWTQVSNPEA-GE----------------------------------------
---------TVPG-------------------------GQAQTGANTESGRQEWSSTHPR
HNV----------TEGQG-----------------------DIQPT--------------
-------VVGEEWVDDHSRET---AIFKLDQGN----LHT--------------------
------------------SVSSAQGQDAAQ------------PE-EKQGIT-ARE-----
----------L--------------------------YSYLRSNKP--------------
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-------------

----------------MPGLLRDVLCIIETFHKYAREDGD-RATLTHGELKQLLQSEFGD
FLQPRV------------IHAVQRKLNLLGVDSASTIHFD-----------E-FVL-A--
-I---------------F-N-L-L-N-F-C-YFD----IQS-----LLT---S-EPRQ--
-VPKP-EKGKPQE------ADLQVTT---GN---------GQQTEG---TMPA-------
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SPAQLSTKES----------------RAAGHYQED-TEGGTTIHNLPRESSEHNSV----
---KIHHL-------------------------------------------------EAG
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EGD-KS----AREQNRA------ETKGQQ--------------QAEQERNLK--------
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-----------------DQ----------EVSAHK-GTKK----------YSESRDLPL-
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ALPATRETSRTQ---KSADPEVE--GP---------------------------------
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------------------SEHTTQKLPVQD----V----SETPDIR--------AEKKEG
EHLKSHGTTGQ-KE--------------------CQS---------------------KI
QPSVL-------------ETPTQDEKD--QELQGPA-------GEKDTERSSKT------
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T--------------E-------GK----------QASYSEEDLEETLVDSTNSSAAKRT
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GKTHDV--SAKADDGYG-----------------------------------DKEPGSPV
TQEEEGSSGTPHSPALEENDYSSETG---------------R------------------
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PET---------------------------------------------------------
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MYKDQEFSSMERGIVHASPRYQNVQEKILEQTDRTQK--------------------KPP
H---------------------------------QNKTAQVLDPE---------LHKTEA
QTFLPRKTSDHPVFISHREVLR---------------QHTKEFLPDEDPVYAQRTPAFQA
WQEEQGHSERAEPVPEREVTST----------------------------------K---
-----------------------------Q------------------------------
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-------------

--------------------------MIDIFQQYSNNDKE-KDTLSKTELKELLEVELRA
VLKNPDD-----------EDIADVFMEMLDVDHNEKIDFT-----------E-YLL-M--
-V---------------L-K-L-A-K-A-Y-YES----TQK---K-RLQ---T-------
GSKRSR-SN-Y----------KGVEEDEEGDEG-RH----ASSHGRTDGK----------
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SSPR-GRGKQRHG-SSSRNHERDT----STHRGKGK--HGKQHNT-TKKHR--G------
---------------------------ES---------NSS--ERRESRGKR-DRRSKER
S--------------------------DLEY-------------DTVRLENTKY-----R
EGWGKS-------------------CIKYY------------------------------
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GKSNRQSSERKQSPDSTR-----------HSGSHQRSQSS-----QRHADSPRDSTRTS-
-----HRGKQE---SQAGQQSTDGPRHSTSSRGRHQEDS-----------------ASQA
SDSEAHS-----------------------------EVE-------------VGHRQTSS
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DSTRHTGAHQSQASGQGR------------------------------------------
GHS---------------------------------------------------------
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GQSAD--------H--SGHSAAGRT------Q-GQAT-----------------------
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------------------------------------------------------E-----
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E---DEHEH-----------EH-----------------EHDQ-A---------------
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--------------------------HDGSRRSGSRQS--------Q-------------
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---------------------------VGSH------TGT--------------------
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-------QSPDSTRQSGS-H-------QRS--------------Q---------------
---S--------------------------------------------------------
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-------------

----------------MSPLLKSIIDIIEIFNQYASHDCD-GAVLKKKDLKILLDREFGA
VLQRPHD-----------PETVDVMLELLDRDSDGLVGFD-----------E-F-C-L-L
-I---------------F-K-L-A-Q-A-A-Y--Y-A-L-G-Q-A-SG--L-D------E
E-KRS-H-G-E-G-K-G-RL-L--QN-RRQ-ED-Q-R-----------------------
-------------------------------RF-------------------------EL
RDRQFEDEPE-----RRRWQK-QE----QER--EL-AEE-EEQRKKRE-RFEQHYS----
-------------RQYR---------DKE---------------------Q-RLQRQELE
E--R----------------RAEEEQ-LRRRK-------------------GRDAEEFIE
EE-QLR----RREQQ---------------------E---LKRELREEQQQRRE------
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------------------------------------------------------------
------------EEEQL--------LRQ--------------------------------
-----------------RRWREEPREQQ-QL-RRELEEIR--------------------
------------------------------------------------------------
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----------------------------------------ER--EQRLEQEERREQ--QL
RREQ--------------------------------------------------------
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--------------------------------------RLEQE-----------------
------------------------------------------------------------
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--------------------------------------------------------RREQ
QLRRELEEIREREKRLEQEERREQRLEQEERR--EQQLKR-ELEEIR-ER----------
--------------------EQRL-----------------E-QEERR----EQLL----
---------------A--EE---VRE---------------QA-----RERGESLTRRWQ
RQLESE-------------------------------AGARQSK---VYSR---------
PRR-QEEQ-----SLRQDQERRQR------------------------------------
-------------------Q-ER---E---------------------------------
-------------------RELEEQARRQQQWQAEE-----ESERRRQRLS---------
-----A-RPSLRE---RQLRAEER----------QEQEQRFREEEE---------QRRE-
RRQELQFLEEEEQLQRRERAQQLQEEDSFQEDRERRRRQQEQRPGQTWRWQ--LQEEA--
-Q---------RRRHTLYA-------KP------GQQEQLREEEE----L-----QRE--
---------------------KRRQEREREYREE-EKL--------QREE----------
-DEKRR-RQERERQYRELEEL-RQEEQLRD------------------------------
--------------------RKLR--------------------------------EEEQ
LLQ---------EREEERLRRQERERKLREEEQLLRQEEQELRQER--------------
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-------------------------------------------ERERKLREEEQLL----
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L-----------------------------REEEQ-------------------------
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RRQERERKLREEEQLLQE-----------------------REEERLRRQERERKLREEE
QLLRQE-EQELRQERERKLREE---------EQLLRQ--EEQELRQERERKLREEEQLLR
QEE--------------------QELRQERERKLREEEQLLR--Q-----EEQE------
----------LRQERDRKLREEEQLLQESEEERLRRQ----------------ERERKLR
EEEQ--LLRREEQELRRERARKLREEEQLLQEREEERLRRQERARKLREE-EQLL--RRE
EQELRQERDRKFREEEQLLQEREEERLRRQ------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------ERDRKFREE
ERQLRRQELE--------------------------------------------------
----------------------------EQFRQERDRKFREEEQQRRRQEREQ-QLRRER
DRKFREEEQLLQEREE-ERLRRQERARKLREEEQLL------------------------
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----RREEQLLRQERDRKFREEEQLLQER--EEERLRRQERERKLREEEQLLQ-------
EREEERLRRQEREQQLR---------------------------RERDRK---------K
--LREE--------EQELRQER------ARKLREEEQLL---------------------
-------------RQE-E-QELRQERDR-KFREEEQLLRRE---------EQELRRER-D
RKFREEEQLLQEREEE--RLRRQERARKLREEEEQLLF----EEQE--------------
------------------------------------EQRLRQE-----RDRRYRAEE---
-----------QFAREEKSRRLERELRQEEEQRRRRERERKFREEQ-LRRQQEEEQRRR-
-----Q----L------RER--------QFREDQSRRQVLE-----PGTRQFARVPV---
-------------------RSSPLYEYIQEQRSQYRP-----------------------
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-------------

----------------MPQLLKSIIDIIEVYQQYVQSDCG-GTALSKKALKNLLQKEFGD
ILRRPHD-----------PETVDLVLQLLDRDCNGFVDFK-----------E-F-L-L-L
-L---------------F-K-I-A-Q-A-C-Y--Y-A-L-S-Q-A-TG--N-E------E
K-RRV-K-Q-E--------------------EN-Q-R-----------------------
-------------------------------KR-------------------------EA
QERQLQEEEE-----LQRAEQ-QE----RER--QR-SEGRQ-QRERPRASKEEQLQ----
-------------QQEP---------EKRLQK-------------------LERRLQERE
R--QV-------QE--RESQRLDDEQ-LQRPGREKQRERQVRE--------GEQK-RRRE
LEQDLR----R---REQRQERAEEGYGKREQERQQRE---RQRERQEESRQERAE-----
--------QSLEEEPQLR---------R-QEERQTREQGESRGLRLQWQLEREVQGRQNK
L---Y-----------SE---------PRRQEDGQ-FLEE-------------E--ARR-
-----RQQRE----ERE--------RR---------------------------------
------------------------------------------------------------
------------------------------QERERQLREE--------------------
--------------------------------------EALPRQ----------------
------------------------------------------------------------
---DRF---GQL-----------RDGDY--------DSFGEEQERQR-------------
------------------------------------------------------------
------REEEQARRRQIRDRQR--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------QEEERRRDLKVQ
WLPQVE-------------------------------AERRRSR---LYSK---------
PSE-QARE-----QERREQRERQL------QE-------E--------------------
------------------------------------------------------------
---------------------EEQLQRLE------Q-----EVEKRREALE---------
-------KRKRQEQRDRQYREEKK----------LQEEKEQLQRLEREEKRRRQEQQDSQ
YREEEQLQEEEEQLQRLEQEVQK------RPKELEKRRRQDERDGQNREEE---------
--------------------------------------QLQEEER---QL-----RR---
------LEQEVEEKREELEKRRRQEQRDGQYREE-EKL-RKEEEQLQRLE--QEVEKRRE
ELEKRRRQEERDGQYREEEQL-QEEERQLRRLEQE-----VEKKREE-------------
---------LEKRRRQEQRDGQYREEEQLQRLEREEKRRSQEQRDRQNREEEQLQEEEEQ
LQHLEQEVEKRREELEKRRLQEQRDGQYREEEQLQEEEEHLQRLEQEVEKRREELEKRRS
QEQRNRQYREEEQLKEEEK--QLRRLE-----------------------R-EVEKRREG
LEKKRRQVKRDRQFREKEQLQEEEEQLQEEEEQVQEEEEQLQRLEREVEKRREALEKRRR
QEEQGKQYREGEKIQEDEEQLQRLEQEVEQRREELEKRRRQEQRDRQYREEEKFQEEKEQ
LQEEEEELQRLEQEVEKRREKLE--KRRRQERRDGQYREREKLQEEEQLQEEEEQLQRLE
REEKRR----RQEQRDGQYREEEQL---QEEEEQL---QRLE-RE-------EKR--RRR
EQRDGQYREEE--QLQEEEEQLQRLEQEVEKRRAALEKRRRQEKRDRQYREEEQLQAEEE
RRQ-----------------------------------------EEREEKRPRLQQRDRQ
YREEEKE-------ELRFQEREE-----QSPESEEFQEQESDLPFREEAQSRRLKW----
QWQPQKENEARNRRLYSKRREDEQREEQDD--SQVRDWPA-------DDEDEYGRGDLDR
PSRYEKSRR-GQDRQFYQDEQEERRSRQEREAEKQRLQERDGLSQEEERRLPQ----ERR
RLQEQDEKFLEEEQLSREEQEE-------------------YEEKKRFRQSRDRKFREEQ
EFRRQD-------------------------------QERRKRLTQTRDRQLQEEEELYP
EER------------------DR---------QYRKERG---------------------
----------SQEP----------------------------------------------
------------------RDRQFQEEKSVLRQQREERRRRQ-----EQEEEQFYGKEREQ
ELRRRQEQDRTFREEEQLRRQEREQ-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------ELRRRQERDGTFPSEEQLR------------EEELEQEQRRRQ
ERDRKFREQEQSLQQAVEEERRQRLEQDRKFREEEQLYREEQEQRRRQEPARRSREEEQL
RRQ-----------ELEQEQEQRRQEPARRSREEEQLRR---------QEL--------E
QEREQRRQEQRRQEPARRFREEEQLRRQELEQEQEQRRQEPARRFREEEQLRRQE-----
LEQEREQRRQEPARRFREEEQLLRQEL---------------------------------
-------------------------------------------E-QEREQRRQEQRRQEP
ARRFREEEQLLRQELEQEREQRRQEPA-RRFREEEQLRRQELEQEREQRRQEQRRQEP-A
RRFREEEQLRRQELEQEREQRR--------------------------------------
-----------QEQRRQEPARRFREEEQLLRQELEQER----EQRRQEPTRRFREEE---
-----------QLRRQELE--------Q-EQEQRRQEREKRVRDEQ-LRRQEGEGQRYRQ
EFDAQTRDQLR------DRQ--------SREEDKNRRQVQD-----FSSRQISKPIV---
-------------------RSSPLYEYIQEQRSQYRP-----------------------
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-------------

----------------MSQLVRSILRVIEVFQSYANADDN-CVSLTKTELKELLQAEFGN
LLRRPRD-----------PKTVDTVLQLLDRDRDGVVDFN-----------E-FLL-L--
-V---------------F-R-V-A-Q-A-C-HQG----LRD---D-ACG-RGRGQGREEE
KGDGRR--PGEAGAQRGRT-----GQTEVT------------------------------
------------------------------------------------------------
-DWRKEDIPR----GQAGGQRRESSSGQSERQRSD---FRDGQSESPRWTSSYGQSEKK-
-DSRSDQSERQRSDFRDGQ------SESPRWTSSYGQSERR-------------------
------------D------------SRSGQSE---TRGERERQRQEVQ-DGRRKRESYPQ
SQWDPETEAQSRRKKLTSQPATS-------------------------------------
----------------------------------------LCHQGPSWQSCESLRARRAG
R---TGQ-----ERDEGQ---------SRQPQGGY-TDDE-------------EQSRQA-
-----RDGQ-R-RQSRGG------QAEEEDQ---------------------TIQ--AGG
VQRGQSRGRQQC---PSQDWQTDEEE-----------PSRQTR--DEQ-RRQSRGGYTED
ED-----------Q--SRQT--RDGQR--------------------RQARGGYL-----
-EEEEQSL---GKKQTSQPATSL-----CHQGPTWQSCELLRARRAGR------------
-----------TGQRKDE------------------GQ-SRQSQDRYTDEEEQS-R----
---QAR---G--------------------------------------------GQRR--
------------------QSR-GGQ---------AEE--------------------EDQ
RV-------------Q-----------------AHRAGRTGQGRDEGQS--------RQP
QDGYTDDEE-QS----R-QARG---GQR---------RQSRGGQA-EEEDQTIQAGGG-Q
RRQSRGRQQY---------------------PSQDW-Q-TD--DEEQS--R---------
-------------QIRDGQ-----------------------------------------
------------------------------------RR-------QSRANRE--------
-------DEDR-------------------SRQIRDGQRRQY---QANMEDEDQSLQAR-
----DGQRHQARGGYIE-EE---EQS---------------REKKRTSQPATSLCHQGPN
WQS---------------------------------------------------------
----------------------------------------CESLK-----ALR-------
-------------AGR---TGQG---R----------A-------EGQNRQPQ-------
--------------D---------------AYTDDE-----EQ--S--------------
----------------RQARGGQRR-Q-----S------RGGQAEE--------------
-------------------------------------------------------EDQ--
-TIQAGGGQRRQSR--------GRQQYP------SQDWQTDDEE----------------
---------------------QSRQIRDGQRRQSRANR--------EDED--QSR-----
--QAR-------------------------------------------------------
------------DGQRHQA-----------------------------------------
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-------------

----------------MSALLESITSMIEIFQQYSTSDKE-EETLSKEELKELLEGQLQA
VLKNPDD-----------QDIAEVFMQMLDVDHDDKLDFA-----------E-YLL-L--
-V---------------L-K-L-A-K-A-Y-YEA----SKN---E-SFQ---T-------
HGSNGRSKTDY----------KGLEEEGEEGNE-QN--L-RRRHGGTDGK----------
-------------------------R---K---SD-----------------------RT
RSPN-GKRGKRQG-S--------------NCRSEGKDKHRR---E-TEKHRHQQ------
---------------------------DSKRKQRH-GSGST--ERKDNRN----KKHRQS
K--------------------------ERNY--------------DEIYDNGKY-----N
EDWEAS-------------------YNNYY------------------------------
------------------------------------------------YKTQNTTLDQRE
GNR-R------LRANSQK---------EPQSSHGQADNND--------FEGGRQQSHSKP
SP--VKADQSRSRAGQAG--SSKVSTRSGSGGRG------------------------QS
PDGSGRS---SN---RRD------------------RPRQ------------PSPSQSSD
------------SQV-HSGAQ-VEARR--------------------GQSSS--------
-A----------------------------------------------------------
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-------------

----------------MPRLLKDVLCVIKTFHKYAQEDGD-KATLTCAELKQLIQGEFGD
ILQ VRC------------SQ SLKRNLNLLDTDSNGTISFE-----------E-FVL-A--
-I---------------F-N-L-L-N-L-C-YLD----IQS-----LLK---P-EPRQ--
-VSKP-EE-KPND------MDLQGTS---GP---------GQWTEQ---IPPT-------
-----------QDRV----------------VPPS----------------------GMT
SSAQLSPMER----------------GAVGHNGV----ENTKTCKLPVDTPGPNDP----
---KNQHT-------------------------------------------------EGD
-------QQNQEVAQDVPATGDNGAQ-LETNK---PTAESEQIYSPTK-QEE-QDKESPM
EGD-KP----VREQRDT------KTWDRC---------------GEQEGNLR--------
--------------------------------------------TQSSLPEKIAQRPSK-
-----------------DQ----------EVAAGK-GVKE----------HSKTQELSL-
------P------------------GKYE-P-------------SSEHA---DLP-----
KQAAAQKPLQTE---KPTDSEDD--GRT----PEIQGQGEDAD------------RTPPK
------------TKN--PAEPGDDGR---------------------VTETQELPAQE--
------------------------------------------------------------
------------------------------------------------------------
------------------KEHETKDLPVQGDSRIV----SETPDVR--------AVRKER
RGPEAHETAGQ-KE--------------------NER---------------------KI
QLLTL-------------EDQPQDGKY--EEPRESS-------KERDAEEGSKT------
-----------------------------------------QELSSEGGDQN-----HPE
I--------------E-------RA----V-TPGEEARHAEEGTAKILLSSKNAPAAEGT
PGARE----------RTQE-----------------------------------------
--------------------------------------------LAPLKN-HSGE-NKKV
TKTHDK--PVKDDDIYQ-----------------------------------GEDPEPTV
TQNNEGSSEIPNSLTPEDSDSSSETT---------------D------------------
--------LPVQGDSQ------------------NQVDPLRESV---------ERSQNNN
ADT---------------------------------------------------------
------------------------------------------------------------
---------------------------------------------EKQVALGQESRTQGA
V------VLAVG------------------------------------------------
-GEDKKLTEEPEWAAREEHK-S--------LGSG-----T-KGPGPAVHPDGHPEAQ---
---ESTARG--KNRKSLETEIPGTLEAD--FTDQFSIRQLPAKED---------------
-------------------TRRKLKVQCLSTKGEEGRAPETQEAPVKNLDEDNSASP---
--KTHLEREE-------TATL--EEDESPQELS-EANDQQNPAKK-RYDVSVPQSSLEEK
IQTDQEPGFVERGTVHSSPLYQYLQEKILQQMDVTQM--------------------EQQ
N---------------------------------QAQTARSSSPE---------LLNNQS
TASLTHEISECPIIFSDSQALQ---------------HYTKGHLPDADLADTEQTSAPQA
SEDKQGYPQEKKPVLQKETGPK----------------------------------E---
-----------------------------Q------------------------------
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-------------

----------------MAQLLNSILTVIKVFQKYAKENGK-CTLLCKKELKQLLLAEFGD
ILQRPND-----------PDTVETILSLLDKDRNGHVDFH-----------E-YLL-L--
-V---------------F-Q-L-A-Q-A-C-YHK----LDS---K-SCG---D-------
RISQ-QEVEQE-G-----TQDHRFPEN-TSR---QH----RQRHDGEKQ-----------
-VSHCP-QSERQNQDAHQ--DQ-SERQDRDSH--------------------------YG
QSERQDRDS--HC-GQSERQDRNSHYGQTERQDRD---SHYGQTERQNRDSHYDQSERQD
RDSCYAQSERQDRDSCNSQSERQDRDSHYGQRWRH-------------KSSS--SQPKRQ
G--YI-------F-------------ALSQYD------KQ------VH-----------N
SRYGQ-------------------------------------------------------
---------------KN----------Q-----QQSGSYHGQSQRMDQ-ESGYGQRDRQE
LYFQYGQTDRQDQHSHYGQ--RD-------------------------------------
-----------------RQGQSSHYGQSERQGQ---------------------------
---------------SSHYGQTDRQG-Q--G------S-----------HYGQEDRQSQS
-------------------S--HYF-------------------------------QR--
---DR----QGQSSHYGQSDRQG--------------------------------QSSHY
GQIDRQGQSSHYGQEDRQGQ----------------------------------------
-----SSHNGQ-------------------------------SNR---------------
----------------------------------------QGQSSHYGQ---V---D-RQ
GQS---------FQCSQTDRQG-------QIFQYGQRDRQAPGSQCSQTDR---------
------QGQNFH----YGQADR--QGQSSH-----YGQRDRQGQSSHYGQTDRQGQSSQ-
------------------------------------------------------------
------------------------------------------------------------
-------------------CSQTDRQGQSFQNGQRD------------------------
------------------------------------------------------------
-------------------------------------------------R----------
---------------YALGSQCSQRDRPGQSSHYDQTDGQGQSSHYGQTDRQDQSSHYGQ
TDR-QGQNSPYGQTERQGLGSQCSQIDR--------------------------------
----------------QGQS-----------------SHYGQTDRQGQSCRYGQTERQDL
SSHY--GQVDRQDQGYHYNQSDRQGLSSCYGWTDRQGQGYHYGQTDRQSLSS--------
----------HYGQ------------S---AIGVTGQNSYLQGSEG-AT-----------
--R-DSYVEQSGRSGRLSQKTQGQEVI-QNQGQRFQSREGQQNSHRAWEP----EEDSQ-
-----------HDQHKLIAEI--QQEKS--HNYKGGDWQSISG-----------------
-------------------KQDH-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------KEEQGQQ-----------------TWGRHGCESQETPWETQARQT
HEEKQNHQRQDRQTLHDEQTHK--------------------------------------
--RWDRQTHEDEQTH-Q-------------------------RQDRQTYEDEQTCQRQKR
QTHEDE-------QTR--------------------------------------------
------------QRRDR-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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----------QTHEKEERYQGSQDQQSYEN------------------------------
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-------------------------------QQRCANREKFHMNEN--------------
----------------------SQKQGS-----QGRHSNLTFH------------PTQTG
GRPPRREQGRSHPTKAA-PTPNPLYDYVQEQKRNQH------------------------
------------------------------------------------------------
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-------------

----------------MTDLLRSVVTVIDIFYQYTNQDGE-CSTLSKDELKELLEKEFHP
ILKNPND-----------PDTVDVIMHMLDHDHNRRLDFT-----------E-FLL-M--
-I---------------F-K-L-T-M-A-C-NKV----LSK---E-YCK---A-------
SGSKKHRHGHQ----------HQEEESETEEE--------EE-------DTLG-----QK
SGYRHSSWSEG-DEHGQS---LGGFRV---------------------------------
------------------------------------------------------------
----------------------------------------T--GQDKYESNA-RRL----
----------------------------------------------------GK------
---PGR-------------------FGGQG------------------------------
----------------------------------------NQS-RGQSSVY---------
-----GH----PEPSSCT-----------QSSSHRG---Y--------------ESRECG
-P------SQNYEGQQRGSSQSSCCGQYGSESSWSCS-------HGQHR---S-------
------------------------------------------GLGQSSSQHGSSSGHTSG
-------------YG-QHGSG-----S--------------------GQSSG--YNQHE-
S-----G--SGHTSGYGQH----------------VSGSGQ-------------------
------------------------------------------------------------
-----SSGYGQQ-----------GSGS--------------------------------N
QSSGF--------E--QHRSGSGQS------S----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------GFGQHGS-----
-------G-------SSHTSSHGQHG-----------SSSGQSSGFGQH-E---------
S---S-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------SGHMSGFGPH-----------------------
-------ETTSGHSSGYGQRESGS----------------------GQSSGFGQH-----
----------RSGS------------------------------SHS---------SGF-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------GQHE--------FGSG-HSSGF--GQHES------
-------GSG------------HTSGFDPHESGSGTSSSYGHHGA-GSSKSSGFGQ----
---------------------------------------------H-GSGSGQSSGFGQH
-GSSSGQ---------SSGFGQHGFGSGQSSGFGQHSSGSSQSS--------GFG-----
----------QH------------GSSSGHSSGFGQHGSSSGHS-SGFGQHGSGSGQSSG
SYP---------VFGEHNTSVDRLSPSLSP--------K--QLLQDSSEA--EH------
KKPE-FQS----------------TGGGG---FESPA------------------R----
----------QSSGFGQHGSS---------SGHSS-------------------------
--GFGQ-----------H------------------------------------------
---------------GS----SSGHS----------------------------------
------------------------------------------------------------
----------S-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---GFVE-----------HGSGSGHSSGF-------------------------------
------------------------------------------------------------
-------------GQHESGSSHSSGFGPHE-SGFG--------HSS-SHGQHGYG--SGQ
SSGFGQHGSSSGHSSG-----------F-GQHESGSGQSSGFGQHESGSGHTSGVGPHES
GSGHSSIHG--------------QHGYGSGQSSGFGQHGSSSGQSSGFRQHESGSG----
------------------HTSGFGSHEFGSGQS---------SGFGQHESGSGHTSSYGP
HESG--------------------------------------------------------
--------------SSQGSGLGQHNSGSGQSSG-FGQHGLSSGHSSGFGQHESGSGHT--
--SGFGPHES--------------------------------------------------
------------------------------------------------------------
----------GSGH--SSGFGQHSSR----------------------------------
----------------------------------SSHSSDFGQHNSGSCHSSGFGQRGSG
SGHSDFGHEFSSTT----------------------------------------------
-----------------------------------------HRQSRDTSRLAH-------
------------SGL---------------------------------------------
-------------GQSTKSGSS--TTGRRRSSHSE----------S--------------
--SDRQSIT--NTTRSHG------------------F-------S---------------
------NEQLA------------------------------------------DSSRHSV
SDQGQT-SQYGQSVYTPSGREGSTHGQTRDRATQSRPAHGQPTSSHGQSLSS--------
-----------------------------------------------T------------
------------------------------------------------------------
-----------------------------------------TPW----------------
------------------------------------------------------------
----------------------------LENSEWEN-------SKNPCTSSIKESSGI--
-GRLN---------------------------------------------NRNGEKSSDR
GQRG--------------------------------------SRASHTSDSE------G-
-----QSEDADT---RS-AAAHER--DEHGQRNHGHSAHSR----SGERARQSGSLLYQV
--------------HSHEQPESSHG--------------QHRSD----------------
----------------SRGTQGSHQ-----------------------EHGRDSSR----
H-SESREGHASSHGQSTSSRARGDQAHHDQ-----------------P--GGRSESQGSR
HHVSD-----S-------------------------------------------------
AHGHSAST----------------------------------------------------
-----------------------------------SASRQRSGQQHSGDLARRSGSRQR-
----DGVRS----------HEQPESSHGQHRSDSRGT--QGSHQEHGRDSSRHSESR---
------EGH-ASSHRQSTSSRAR----------RDR------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---AHHDQPGGRSESLGSRHHVSDSAYDHSASTSASRQRS---G------------QQHS
GDLARRSGSRQR-DG-------S-------------------------------------
------------------------------------------------------------
-PHEGRSRRSQ--S---------GQGLASESRTSR---HQGSNLSQDSESEGHLEDLEGQ
AASDSRSHHAS------TRGLHSNPLSQ--------------------------------
-------------GSRKRDASDLGWKHGSYGSTNYEY---GLTGFGKSQELTHGQSEYGG
KQSWASPRKRQGSRHGESE---------------------SEEPPWHLGGGGWGEKIGPL
QPPHT------LHSTSIKHGECASGSKQRYHNH---------------------------
------------------------------------------------------------
----------------------QHQEEQS--EIQEEEDKGQESSSSHSSWSAGE-NESHS
RDSTGSIKQGPRRIGHQGTLSSSGKKQS---LGKR---T--------------ES----S
-------------SSHFKGNEKNKHDS--YQQ----------EMSTNEES----------
-----------------------GYTYSYSCGEKRHVSHSENQSSNSDQHWSDSNESPEN
RRHNTDSG-------------------------------------TWEKEKHKSVSRRPS
I-----------------------------SEQYGP-GFSELSQ----------------
----------HRKNNSRSIHSTI-----------QRQKISHAQSQAEHRRPKKNDFEVTW
YTSDEDCGSDSET-SRKN-----KKKHS--------------------------------
------------------------------------------------------------
------------------SAYQSNSQKK---------LKRSSSNQSE-----------SQ
QGYVSDQYSKYDEE------------------------------------KSNIQEYANY
DQNGTASLRSKNKRSNESTSGWT------SSN---TRIRSPSGNFSNYRKDDSTS-RG--
-----------SSISAKESSTQVSSEFR---NYRHT--QHQSSSYGGNGYTSEEESSCSE
QDYTSGHSSNSGEHGYTTGKPYANREQ--LSSSQKTISHNEHRNGSGQSSGYRKHQLDTS
ESSSYSQEES-----KICGRHGSGSGQSSTLGRHESGSSQSSGYGRHGSGSG--------
-----------------------------ESTS---------------HSQRGSGSG---
--HQSSSHGQHGSASGQSSSCGQH-SSSSGHSSGYGPHGSGSSLSSGSGQH---------
----------------------------------ASGSG---------------------
------------------------------------------------------------
--------QSTTHGRHGSGSGQSSGYGQHPLGS-----------------SQSLNIGEHQ
SGSIP-----------------SNTHGRHGSGSGQSSSYGQQ------------------
--TSGS-------SQT------SRY------GQHASGSGQ--------------------
------------------------------------------------------------
-----------DTSHGQCWSGS--SQSSSYL-----------------------------
----------QHVSGSGPSRIHSCRGSGSGQSSIHRQHV---------------------
-------------------------------SGSGYYSSSGQYWPLSGESPSHGRHCSLS
GHSCSFGQHGFGSRHSSIYGHHGSVSGQSSGFGHQKSSTFYSSSYSQHAS-SSEYS-SY-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-------------

----------------MPELLKSIVTVIDLFYQYATRDGE-CDMLNKAELKELLENEFHQ
ILKNPDD-----------PDTVGIIMQNLDQDRDKKVDFI-----------E-YLL-M--
-I---------------F-K-L-A-Q-A-C-NKI----ISK---D-YCQ---A-------
SGSKQRDHNHQ----------HQEEESETKEE--------D---------KRQ-----G-
----HSRSSTG-END--S---RGS-RR---------------------------------
------------------------------------------------------------
----------------------------------------S--NKHRPGSSS-RRM----
----------------------------------------------------DH------
---QGG-------------------LSSSE------------------------------
----------------------------------------HRQ-SSGERRRE------S-
---SSGH----FKE----------------------------------------------
----------------------SKKNRHGSYEQER-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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---SESHSSG--------------------------------QRQHRT------------
------------------------------------------------------------
----NKSGQ--SG----------LSRQ-------------RK-Q-----STSNEGYGSES
---G----QSISN--GKN--------QSNS-YESSTQR--------KHS-----------
---SS--------STH-Q--------SGGYGRQNH-----GS------------------
------------------VSGQ--------------------------------------
------------------------SSNYGK------------------------------
------------------------------Y-------GPGFN-----------------
-------QSSNQKYHES-------------------------------------------
-----------------------------S-------S--GSS-----------------
---------------------------LGESSSCRQQ-----------------------
-------GFGSG-----------------------------------QSSGYEQH-----
-----------------------RSG-----------------SGQS---------SGF-
GQH------GSGL------GQSSSYRQNS-------------------------------
------------------------------------------------------------
-------------------------STS----G-CSSS-----------CGNYGSGSSQ-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------S--------------SSHSQHWS
--------------------------------------SSG-ESSHY--GRHSS------
-------GSS------------QYSGHSQHGSGSRESSSNGQHRS-GSSPSFSPSR----
---------------------------------------------H-GLGTGQSSGFGQH
-GSGSGQ---------SSSHSQHRSESGQSSGYGRHRSGLGQSS--------AYG-----
----------HQ------------GSGSGQSSGFGQHESSSGES-SG-TEHRSGLGQSSS
SGQHKSGY----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------GQSSSYGQHGSTLG-QSSCGQHG-SGSG--------QSS-SYGQHRSG--SGQ
SSGYDQHRSGS-------------------------GQSSEYGHHRSGSSQSSGFGQHGS
SSGHSYGFG--------------KHGSSSGQSYGFGQHESSSGESSGT------------
------------------------EHGSSLSHS---------SNSGQPESGYSQSSSYGQ
HGSAS-------------------------------------------------------
---------------------------GQQSSS-GGQHESGSGQSSGYGQHRATSGQS--
--SIYGYHES--------------------------------------------------
------------------------------------------------------------
----------GSGQ--SSGFGQ--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------H------------------W-------S---------------
------GSSHH------------------------------------------SSYGQPG
SESGQS-SGYGQHGSGSG--QSSGHSQYGSGSGQS-STYGQYGSASGQTSNCDQ------
--------------------------H-----------------ESGS--GQSSGYGQQR
WGSGEFSRNG--------------------------------------------------
-----------------------------YHESGSGQSAGYGQH----------------
------------------------------------------------------------
----------------------------GSGSSQSS-------SYARHGSGSAQSSGF--
-GQH----------------------------------------------GSGSGQSSSY
GYHR--------------------------------------SQSGQ-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------CSGHGQYGSGSSQ--------------------------------------
----S-----S-------------------------------------------------
SYGQYGSA----------------------------------------------------
-----------------------------------SGQTSSCGQHES-GSGQSSGYGQQ-
----RSGSGQSSLYGHHGSGSGQSSGFGQHESSSGESS-------------GNE------
--------Q-GSGLGQSS----------------SS------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---GQHK-----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------S------GYNQSSNYGQH--------------------------------
-------------GSTFGQ-SSSSGQHASGSGQSSG--------------FGHG------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------QYGS--GSSQSSS---YGH----W--------------SGSGQFS
GC-------------GQHGSESGQSSG--FGQ---------HSSGSGQSS----------
-----------------------GYGEHGS--------G-YTQSSSYGQHGSG-------
------------------------------------------------------------
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----------FGQHGSGSGQS---------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------FSHGHHRSQSGQCSGHGQYGSGSS--------
-----------------------------Q------------------------------
----SSSYGQYGSAPGQTSSCGQH-ASGSGQSSGYGQHGSGSSQSSSYSHH---------
----------------------------------GSELG---------------------
------------------------------------------------------------
--------QSPGFEQHGSGSSQSSSYGQHRSGS-----------------GQSSGFGQHG
SGSSQ-----------------SSSYGQNGSRSAQSSGLGKH------------------
--GSGS-------GQS------SRY------GHQRSRSGQS-------------------
---------------AGHGK----------------------------------------
------------------------------------------------------------
------------------------CGSGSGQSSSYGQSGSAAGQISSCGQHASG------
--------------------SGQSSGFGQHGSGSSQSSSYGQNASGSGQSSGYGQHGSGS
SQSSTYSKHGSGSGQSSGFGQHGSGSSQSSSYGQHASGSGQSSGFGQHES-GSSQYPSYG
QHWSGSGQSSGSWQHG-----------------------SGQSSSYGRHRSGSSRSSSHS
RHGSGSGQC----------------------------SSSEQYGSGPC---HSSSSEQCG
SRFGQCSSSEQY------GYGSCHSSTSGQCGSGS--GQYSHSE----------------
------------------------------------------------------------
-----------EYRS-----------------------------CS--------------
--------------------YHPSSSGKCGSESGQCSSYEQHEIQGR------CRSS---
---SSE--TRNEYSRPKMC------LIP--NRSRSN-----SQEWSECG----------Q
NER----GRSYGLSDSGPDGY----------------ESIH--------------GQSRT
CRQQ--------------------------SQGWSQGPSDYIHSNCNEEQIRSSY-RQ--
------------------------------------------------------------
------------------------------------------------------------
----------------------------EV---------------SSSSCGSRQFT-PYG
HSRSNTTN-TLLICKEGNIQGDYCYK-RGGDNCA----GGSTSPSSQSFPSSTPLYKYIQ
EQRCQF------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
-------------

----------------MSPLIRSIVDITEVFNQYASQSCD-GASLSKRELKNLLERELGD
VLQKPHD-----------PETVDLTLELLDRDCNGRVDFN-----------E-F-L-L-F
-L---------------F-K-I-A-Q-A-C-Y--Y-A-L-D-Q-A--A--E-L------G
E-KRT-L-T-K-E-K-R-SL-S--QD-RRQ-ED-Q-R-----------------------
-------------------------------RF-------------------------EP
RDRQLDEEPG-----RGSWQKRRE----QEE--RA-EELRLE----------QRDR----
-------------QHRD----------EEQ-Q------------------LQRRELQELE
E--R------------------------------------LAEKEPLSWSKGRDAEEFSE
VEEQQR----QERQE-------LKGKGQTEER----------------------------
--------------------------------------RLQRR------RQEE-------
------------------------------------L--R-------------E--PLL-
-----R------------------------------------------------------
------------------------------------------------------------
--------------------------REQDLNRRQEL-----------------------
-----------------------------------------R------------------
---QELRREP---ELR-------------------------REQELSRGQEQRREQ--EL
RQELRR-------------------------------------------------EQE--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----LRREQVLRREQE----------------------LRQE------QRREQELRHEQ-
------------------------------------------------------------
------------------------ELRQELRR----------------------------
----------------------------------------------------EQALA---
---------------EE--D---EQT---------------RV-----REPDQSITQRWQ
WQLESE-------------------------------AEARQNK---VYSR---------
PRR-QEQR-----LRQELEERQLR------------------------------------
------------------------------------------------------------
-------------------EEEGQRRDLQRQRPAEE-----ARQRY--------------
-------------QWERPQRAEER----------LEQEQRFRDREEQR------------
------FR--EERLQRAELQDS------LLE--EEQRRRQAERREPNASWE--LREES--
-----------QRRHTLYT-------KP------SLRQRREEELR-EERL-----LQEE-
--------------------QRQQR--ERKYRR---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------EEDLQQEE------------------------------------
-------------------------ERLQQDEEQ--------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------LQREKRRLQQERQYQEEDLQLEEER
LQQ-------------------------------EEERLQ---RE------RRRLQQERQ
Y------------------------------------QEEDLQRLQDEDRRRDLKW----
QWQPRKEVEVRSNRLFTKRREDEETIQQLED-SREQ--GRRQDRRPLQNEQE-----ERR
ELEQERRRLQQRDRQILEEEQ----LQREQ---QREARRRDETFQEEEQLLEE-SR---R
QQQEREGKFLEEERQLQTERE-----------------------EQRRHQEQEREFREEE
EER---------------------------------LQEPEKELRQERDRKSREEQERRQ
QRE------------------EEQLRRQERDRRFRREQEQRQETE-----EEQLRDRPFR
REQERRQEREEEQLRDRKFRREQEPRQEREEEQLRDRKFRREQEPRQEREEEQLRDRKFR
REQEPRQER----VEEQLRDRKFRREQERFQEREEEQLRDR----PFRREQ-----ERRQ
EREEEQLRDRPFRREQELRQEREEEQLRDRKFRREQERRREREEE-----QLR-DR--KF
RR--------E-QER-RRER--------------E-------------EEQLRDRPFRRE
------QERLQEREE-E-----QLR----DRPFHREQERRQE------------------
-ERDRPSRRE--------------------------------------------------
-----------------------QELLR-----ELEEEQLRDRKFRREQELRRDRKLREE
EERRPE-LE-----EEQLRGQERD------------------------------------
-------------RLRVEEQLRQEREEEQRRRQERDRKSREEQELRQELEEEQ-----LR
DRKFRREQELRRDRKL-------QRERKFRLEQELRRERE--------------------
-------------------EEERRQQRDRKFRREEELRQELEEEQLRDRKIRR---EQEL
RRDRKFREEEERRQEEFEEKQLRLQEPDRRFRREQELRRK--------------SREEQE
LRQEL----EEEQLRDRR------IRQEL--QEEELRRQERDSKFLEEQEIRR-------
ALQEEELRRQERDRKFREEQELRQELEEERLRDRKIPREQEFRRP------REEEQLRDR
KFRR----------EQEFRREPG-VEQRRRQEREEEQIR--FEEQQQRRQEREQQLRQER
DRRVREEEELRQEREE---LLHREVGG-RKFREEERFRQEREE-------QRRHLQERDN
RRFREEVELRQEREEQQLRQERQERERKFREVEELRQ-----------------------
---------EEEQRRRQEFDRKFREEKRLR--EEREGQQL----RREKRDGQYPAEE---
-----------QFARDKIRRQ-EQELRQEEEQRRRQERERKFQEEQ-IRR----------
-----------------------------RQEEQRRRPILE-----PGTRQFANVPV---
-------------------RSSPLYEYIQEQRSQYRP-----------------------
------------------------------------------------------------
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-------------

----------------MTDLLRSVVTIIDIFYKYTRQDGE-CGTLSKEELKELLEKEFHP
ILK NPDD-----------PD TVDVIMHMLDRDHDRRLDFT-----------E-FLL-M--
-V---------------F-K-L-A-M-A-C-NKV----LSK---E-YCQ---A-------
SGSKKHRHGHQ----------HQEEESETEEE--------EE-------ETLG-----QK
SGHRYSSWSER-EKHGYG---SGGSSGTVKHRRGS-----------------------K-
-SRRLGRRD------------------------GLSSSENEEGSE-KRSHGSHS------
---------------------------GHFWS--------S--GKERHGSRS-EELGERR
N--------------------------KSSV-------------SPS------------G
EEYEYG-------------------SG---------------------------------
--------------------------------------------SKSRGRKAHGGLSHGL
EAS--GH-----E-SSST---------QSRSG-GQSL-----RSSSGGSGDCGRQSHTCN
SS---------------------------------------------------------N
SEGYGRS---QN---ASSSCQAGRFGGLGNQSSCT-QSGYESGSSEGQGHGGISGGQSSG
CQFSGYSQHNSGSSS-QSSSHRGHES----------------------RARGQ--PQNSR
GRQQGTG--SSQSSCYEQY-----------------------------------------
-----------------------------------------------G-------S----
-GVSQSSSYGQY-----------EYGSC-GSSSTSSQKRSGSNEFS--------------
---KR--------G--QLDPGSGHF------S-SQHR-----------------------
---------------------------------------SSSSQSSGQH-----------
---GSGPSQ-SS----YGQHGS---G-----------------SHQSSGQH---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------GSFTGQS-
------------SS----------------------------------------------
----------QHRSSSSQ--SSSQHG-----------SGTAQFS--GQHGS---------
G-----------------------------------------------------------
--------------SSQSSFNQH---G----------S------GSGQSSGFG-------
----------QH-GS-------GLS-----------------------------------
-----------------------QS-S-----Y---------GQHGSGS-----------
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-SQSSGQHG--SC---------------------TGQS----------------SSQ---
-------------------------------HRSS-------------------------
---------------------------SSQSSGQH-----GS------------------
------------------GTGQFSG-----------------------------------
--------------------------QHGSG------SSQ-SS-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------FGQH-----------------------
-------GSGSGQSSGFGQHGS-GL-S-QSS--------------------YGQHG-TSS
SQSSG-Q-----------------------------------------------------
---------------------------LGSCT----GQS----------S---------S
Q--H---RS-SS--SQSSG-QHG-SGTGQF---S--------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------GQQGSGSS-QSSFGQHGS-GSG-QSS-GQ----
-H-VS-GS-SQ-SSY-S-HHGS-GS-SQ-SS----------GFG----------------
----------------------------------QHESGSSQSS----------G-----
----------QHLSGSSQSSYGQHGSGSSQSSG--QHGSCTGQS-SSR--H--RSSSSQS
SGQHGSGSSQSSGFGQNGSSS------------------------SQS-SYGQH------
GSQSSQ-------------------FSEQ---HGSGS------------------G----
----------QFSGFGQHGSG---------SGQSSG------------------------
------------------------------------------------------------
-----FKQ------YES----RSSQ----S------------------------------
----------------------------SGQH----------------RSGS-------C
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------QSS--RQQGY-GSSQS--------------------
---SYGQHGSG-SG--Q--S-SY-GQ-------------HGC---RS---SQSS--G-QH
GPGIS----------------Q-SSYGQHR-SSSS--------Q---SSGQHGYG--SSQ
SSGFSQHGSGSGQTSG------------FGQHELGSRQSSHSGQHSSGSGQSPSFEPQGS
SSGKLSSSG--------------Q-------------HRSSISGKGSCGPTSDHEVP---
-------------------SHE----KSGSSRR---------Q-----QSSQRQSSDS--
------------------------------------------------------------
------EWQSEDSQRHSGSTHGQSGSQQGES--GSS------------RRQGTSHEQS--
--GDITRH------ASSGHG---------------QLTESGSGTTRRRD-SSHSQSSDSE
QHSGDSQ----RHSESTHGQSGSQHGESGSS-----------------------------
--------------------RRQGSSHGHS-----------------------GETTRHD
QSGHGQLTQSGSRTTERRDSSHSQSSDSEWQSEDSQR---------HSGS--THAQSGSQ
QGESGSSR----------------------------------------------------
------------------------------------------------------------
-----------RQGTSH------------------------------------------E
QSGDITRHASSGHGQLTESGSG--TTGRRGSSHSQQSSDSEQHSGDSQRHS--ESTHGRS
RSQHGESGS--S--RRQGSSHGQSGETTRH----ANS---GHGQLTQSGSRTTGRRD-SS
HSQSSDIEQHS-----------------------------------------GNSYRHSR
SGHDQSGSQHGESGPSR--RQENFHGQSGDTTKQA---------------------QSSH
GQRTESGSRHTASTYG--------------------------QSGSSSKQSVSNSTRTYE
SSNEHS-------------------------------------------------EDIPK
HSVSHQ------------RQTSPYGQSGYRTSGRQGS-----------------------
------------------------------------------------------------
-PHVQRGDRSTHSG------------S-IHGQSGSRTISSSSHH--QPGAN---------
HSQS----WSSQR--------------------------QRHGSGQGWKHGSYGRAAYDY
GESGYGPSGGSRASNHNSNQEDSSRVGN-HKCVSGQSFTYSS--IGGTSERH-----HQN
KEL----------RHGWRRQGQTSRPVRHGN-----------------------------
-------ATRP-------------------------------------------------
------------------------AGQYSIHGRNS------------RQESGHGRQ----
----------------A-----------------------------------------SG
TQQSGPPGT----NHNGFTHHQSRGTRHS----------------GSNQEHRSDSQQSHS
THKYSLSAARGRQGSRHGHSVDSPTHSGSDQGEIS-----SHGQSRSSTKSTQ--ESHQE
HAADH-------------P---RHSGTGRHRGSSVSQASDSEGQ--SEDSHRQSGYT---
-----ATHYHGSTHGQSRDSSRHLGSHQGRRADAPQSHPAHGHS----DSTARGRQSSSH
GQSVDSSRHSSSHQGETSPQE------ESRSSTRGRQ-E-TQQEHSADHSRHS-VAEHGR
SLSESGAGRHRGSSVSQASD----------------------------------------
--SEG QSEDSHRQSG---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------SASGHHHGSNHGQSRDSSRHSGYHQGHRADGPQSHSAHGQTDSTARGRQGP
SYGHSVDSSRHSGSH-Q-------------------------------------------
------------------------------------GEISTH GQSRSSTRSRQESHQEHS
ADRSRRSGPGH---------------ARPS-SESGAGRHRGSSVSQASDSEG QSEDSHRQ
SGSASRH------YHDSTHGQSRDSSR---------------------------------
-----------------------------------------HSGSHQGHRADGPQSHPAH
GHSDSTARGRQSSSHGQSVDSSRHSSSHQGETSAHG-----ESRSSTR------GR---Q
ETQQE-HSADH-------SRHSVAEHRQ--------------------------------
-----SSFESGAGRHRGSSVSQASDSEGQSE---------------D-------------
----------------------SQRQSGSASGHHHGSNRGQSRDSSRHSGYHQGHQADAP
HSHS--------------------------------------------------------
------------------------------------------------------------
---------------------------------AHGHTDS---TTRGGRQGPSYGHSADS
SRHSGSRQGETSVHGQSRS--S--TRGRQ-------------------------------
----------------------------------------------------ESHQEHSA
DSS--------RRSGPGHARPSSESGAGR---HRG-SSVSQASD--SEG-QSEDSHRQSG
-------SA-SGHHHGSNHGQSRDSSRH-------SGYHQ---G-----------HRADG
------------------------------------------------------------
------------------------------------------------------------
-----PQSH---------------------------------------------------
PAHGHSD--STARGRQGSSHGQSVDSSRHSDSQQGET-------------S--------A
RGQYRSSTRDRQ-----------ESHQDHSADQSRYSGA---------------------
-GNT--------------------------QKQSGYSSTHYHGSTHGQS----RDN-S--
--------------------RHSGSLQEH-------------------------R-----
---------------------------ADGPLS------------H---------S----
---DSSARGRQGSSHGQSVDSSRHSGSHQGETSAHGESRSSTRGRQETQQE---------
------HSAEHSR--HSVA--------EHVQSSHESEAGR-----HRGSSVRQASDQEG-
QS---EHSRSQSG-----SASRQDRSTYSQSRDSSRH------------------SGSHQ
GHRAEAPQ-----SHSAHGHSYSTAIGTQDSSQGQSFDSS---RHSGSHHGEAS--A-RG
ELRSSSRGRQ-ES----HQEHSADRSRHSGTGHGRSSF-ES---------------GTGR
ERASSVSQASDIEGQSEG------------------------------------------
----------------SVGQSTSYHGSS---------------GFGSRNQPGSIHGQSGD
SLRHSGLHSGQISTQRQSDSTHV-------------------------------------
----------------------------------HQSQKADHG-----------------
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-------------

----------------MAPLLNSILTVIKVFQKYAKEDGD-CALLCKKELKQLLLAEFGN
ILRRPND-----------PETVETILNLLDKDRNGHVDFR-----------E-YLL-L--
-V---------------F-Q-L-V-Q-A-C-YNK----EEN---K-ACG---D-------
RTSQ-QEGEQE-G-----TQDHSFPGN-TGR---QH----RQRHEEERQ-----------
-DSHHR-QSERQDRDSHY--GQ-SEKQSQDSH--------------------------HG
QSERQGQDS--HH-GQSERQGQDSHHGQSERQGQD---SHHGQSERQGQVSHHGQSERQG
QDSHNGQSERQGQDSHHGQSERQGQDSHHGQSERQGQDSHH-------------GQSERR
G--QD-------S-------------HHGQSE------RR------GQ-----------D
SHHGQS-----------------ERRGQDS------------HHGQ-SERRG--------
--------QDSHHGQSE----------R-----QGQDSHHGQSERRGQ-DSHHGQSETQD
RNSCYSRSERQGQDFSSDQRLNHKSSSDQTKREGYLFALTQYETQVQDSHDGW-------
-----------------SEGLRQQQSQPRILREDSCCSGRNQQESGSYY---GHSARLGE
ESGYHQRDRQE---FDSQYGQTYRQG-Q--H------S-----------HYGQADRQGQS
-------------------S--HYG-------------------------------QA--
---DR----QGQSSHYGQADRQG--------------------------------QSSHY
GQADRQGQSSHYGQAGKQGQ----------------------------------------
-----SSHYGQ-------------------------------ADRQGQSSHY-G--QAGK
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-----------------------------------------QGQSSHYGQTDRQGQSSH-
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-------------------YGQADRQGQSSHYGQAD------------------------
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TDR-QGQSSHYGQADRQGQSSHYGQADR--------------------------------
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SSHY--GQTDRQDQSSHYGQADRQGQSSHYGQADRQGQGSHYGQADRQGQSS--------
----------HYGQADRQGLSSQCSQS---EPGETGQNRCFQGNER-TS-----------
--R-GSYVEQSGSSGRPSQQTQGQKVN-QNQGQRFQPRLEERNSHQAWEP----EEDCQ-
-----------HHQHKLVAQI--QQERP--HSHKGSD-----------------------
-------------------RQGHREAQTKESHGE--------------------------
------------------------------------------------------------
--------------------------R---------------------------------
------------------------------------------------------------
----QSHQV------EEEKGHQ-----------------IRGRHGHEGQETPCETRDRQT
HEEEQSHQTRGRKTHEDEQNHQ--------------------------------------
--RQDRQPHEEDQNC-Q-------------------------------------------
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----------QTHEKKEKYQGSQDRQSHGT------------------------------
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-------------------------------QRGSANREKFHMNED--------------
----------------------DQSQGS-----QGRHSDLAFH------------PTQSR
GRPQRREEGGSHPTKAA-IAPNPLYDYLQEQREHWH------------------------
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-------------

----------------MTDLLRSVVTVIDVFYKYTKQDGE-CGTLSKDELKELLEKEFHP
VLKNPDD-----------PDTVDVIMHMLDRDHDRRLDFT-----------E-FLL-M--
-I---------------F-K-L-T-M-A-C-NKV----LSK---E-YCK---A-------
SGSKKHRRGHR----------HQEEESETEED--------EE-------DTPE-----HK
SGYRHSSWSEG-EEHGYS---SGHSRGTVKRRHGS-----------------------N-
-SRRLGRQG------------------------NLSSSGNQEGSQ-KRYHRSSS------
---------------------------GHSWS--------S--GKERHGFSS-GELRERI
N--------------------------KSHV-------------SPSR----EF-----G
EEYESG-------------------SG---------------------------------
--------------------------------------------SKSWERKGHGGLSCGL
EIS--GH-----E-SNST---------QSRSR-GQKLGSS-----RSCSGDSRRRSHACG
YS---------------------------------------------------------N
SSGCGRP---QN---ASNSCQSHRFGGQVNHSSYI-QSRCQSGINGGQGHDCVSGGQPSG
CGQ-----PESNSCS-QSYSQRGYGA----------------------RENGQ--PQNC-
GGQQRTG--SSQSSFCGQY-----------------------------------------
-----------------------------------------------E-------S----
-GGSQSCSNGQH-----------EHGSC-GRFSNSSS----SNEFS--------------
---KC--------G--KHRSGSGQF------T-SCEQ-----------------------
---------------------------------------HGTGL----S-----------
---QSSG---------LEQQVA---G-----------------SSQTCSQY---------
------------------------------------------------------------
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----------------------------------------------------GSRSSQS-
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------------------------------------------------------------
------------------------------------------------------------
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---------------------------------FGQH-----------------------
-------GSGSGQSSGFGQHES-RS-G-QSS--------------------YGQHS-SSS
SQSSG-YGQHG-------------------------------------------------
------------------SRQTSGFGQHGSGS----GQS----------T---------G
FGQYG-SGS-GQ--SSGFG-QHG-SGSGQS---SGFGQHESTS--GQS------------
--------------------------------S-Y-------------------------
------------------------------------------------------------
-------G--------------------------QH-GFG--------SS-QSSGC----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------GQHG--------LSSG-QTSGF--GQHEL------
-------SSG------------QSSSFGQHGSGSGQSSGFGQHGS-GSG-QFS-GF---G
QH-ES-RS-RQ-SSY-G-QHGS-GS-SQ-SS----------GYG-QHGSKW--TSGFGQH
-SSGSGQ---------STSFGQYGSGSGQYSGFGQHGSGSGQSSG--------FG-----
----------QHESRSGHSSCGQHGFGSSQSSGCGHNGSSSGQT-SGFGQHELSSGQSSS
FSQHGSGSGQSSGFRQHGSGS------------------------GQSSGFGQH------
ESRSHQ------------------SSYGP---HGSGS------------------G----
----------QSSGYGQHGSS---------SGQTSG------------------------
------------------------------------------------------------
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L------S----------------------------------------------------
------------------------------------------------------------
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-------------------------------------------------------QS--S
G-FGQ-H-----------ET-GSGQFSGFGQHES-RSHRSS-YGQHGS-GSSQ-SS----
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GSGLG---QSSGFGQHGTGSGQSSGFGQHE-SRSH--------QS--SYGQHGSG--SSQ
SSSYGQHGSSSGQTSG------------FGQHRSGSGQSSGFGQYGLGSGQSSGFGQHGS
GTGQSSGFA--------------RHEYRSGQ-SSYGQHGTGSSQSSGCGQHESGSGP---
-------------------TTGFGQHVSGSDNF---------SSSGQHISGSGQSTG---
------------------------------------------------------------
-------FGQYGSGSGQSTGLGQGESQQVASGSTVH------------GRQETTHGQT--
--INTARH------SQSGQG---------------QSTQTGSRVSRRRR-SSQSENSDSE
VRSRVSH----RHSEHIHTQVGSHYPESGST-----------------------------
------------------VHRRQGTTHGQR-----------------------GDTTRHS
HSGHGQSTQTGSRTTGRQRFSHSDATDSEVHSGVSHR---------PHSQEHTHGQAGSQ
LGESQSTV----------------------------------------------------
-----------------------HERHETTYGQTGD------------------------
------------------------------------------------------------
----ATGHGYSGHGQSTQIGSR--TTGRRGSGHSES-SDTEVHSGGSHRPHSQEQTHGQA
RSQHGESGS--TVHERHGTTHGQTGDTTRY----AHY---HNGQSTQRGSRTTG-RG-SG
HSEYSESELYS-----------------------------------------GGSHTYSG
HIHGQVGSQHGESDSIVHERYGTTHGETGDTTRHA---------------------HYGH
GQSTQRGSRTTGRRGSGHS-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----EYSDSEGHSGISHTHSG-----H-S--QAGSQHGESGSAIHGRQGTIHGQTGD---
------------------------------------------------------------
------------------------------------------------------------
-------------------------TTRHAHYGHGQSTQR--GSRTIG-RRGSGHSEYSD
SEGHSGGSHTH-------------------------------------------------
--------------------------SGHTHGQAGSQHGESGSVVHGRQGTIHGQTGDAT
RHGQ--------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------SGHGESIQTG------SRTIGRRGSG-----HSEYSDSEGHS-GGSH--
---------------THSGH----------------------------------------
--THGQAGSQHGESG---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------SA-------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------T
GDTTRHGQSGH---------------GQSTQTGSRTTGRRVSGHSEYSDSEGHSGISHTH
S-----------------------------------------------------------
-------------------------------------------------GHTHGQAGSQH
GESGSSGHGRQGTTHGQTGDTTRHAHYGHGQSTQRG-----SRTAG--------------
------------------------------------------------------------
--------------RRGSGHSEYSDSEWHSGGGSHTHSGHTHGQARS-------------
----------------------QRGESGSAVHGRQGTIHGQTGDTTRHGQSGHGESKQTS
---S-------RTIGRRGSGHS------------E-------------------------
-----------------------------------------YSDSEGHSGG---------
-----------------SHT--HSGHTHGQAGSQHGESG----SVVHGRLETTHGQTGDT
TRHGHSGYGQSTETGSRST--R---TSHFQSH--SSERQRHGSSHVWK---HGSYGPAE-
-------------------------------YDYGYTGYGPSDG-RRK-SIWSSHLSCSI
DSATNE--QLSRH-----------------------------------------------
------------------------------------------------------------
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-------------

----------------MPQLLNSILNVSKVFQDYAEYHGV-GASLSKKELKQLLLTEFGD
ILRRPND-----------PETVETILEHLDRDRNGYVDFH-----------E-YLL-L--
-V---------------F-Q-L-V-Q-A-C-HHK----LDS---K-FYG---S-------
RTSSQKEHDQE-G-----TRSHKFSES-TGR---QH----RQRYEGERR-----------
-NSHHN-QSEGQHQNVQH--DQ-SQRQDKDS-----------------------------
-----------------------------ERHDTD---PHCGQSETFHGDSHYGHSERQD
TDYSSDQSE------------SDNESSSSSQRLGY-------------KSSH--EQPKGQ
G--YV-------F-------------ALSQSK------NP------EQ-----------A
FHYGQS-----------------KTSGQQS------------SHGQ-SGRFR--------
--------KDSYSSQTS----------Q-----QESDSYEQY-GSQHQ-KSGNSQTERQG
QNSQYGQTNKKGHSSYHEQTE---------------------------------------
-----------------GQGQSFHYGQKGRKDQ------------SFQQ---GQKGRKDQ
SPHLGQKGRQD---QSPHRGQKGRQD-Q--S------P-----------HQGQKGRQDQS
-------------------P--HRG-------------------------------QK--
---GR----QDQSPHQGQKGR----QD-QS-------------------PHL--------
GQKGRQDQSPHQGQKGRQDQ-----------S------PHQ------------GQKGRQ-
---DQSSHQGQ------------KGR--QDQSSHQGQ-----KGRQDQSSHQ-G--QKGR
QDQSS-HQ-GQREGQD-QNSQWHRTD----------------------------------
-------------------SQG-------QSFHYGQTGGHSLSSHQGQTD---SQGQNSN
WHRTDSQGQSFH----YGQTGG--QGLSS-HQGQ----TDSQGQNSNWHRTDSQGQSFH-
------------------------------------------------------------
---------------------------------------------------FD-------
QAGREVQ---------GSHHGQTDRQSQNSNWHRTD------------------------
----------SQGQSFHFDQA-GKEV-------------------------QG---SHQ-
GQT---DSQGQSSHWHQ-TD-----------------------------RQGQSS----Q
QGH--------KDR-QGQNTHQGQKGRQDLSPHQGQKGRQDQSPHLGQKGRHDQSPHQGQ
KGR-HDQSPHQGQKGRQDLSSHQGQKGRQDQSPHLGQKGRHDQSPHRGQ-----------
-------------KGRQDQSPHQGQKGRQDQS-----SHQGQREGQDQNSHWHRTDRQGQ
SFHY--GQTGGQGLSSHQGQTDSQGQNSQWHRTDSQGQSFHFDQAGREGQSS--------
----------HHGQTDRQSQSSHCGQSEIGKTENQGQNRHSLGTDR-TR-----------
--R-DSYVEQSGRSVKLSQQNSREEVR-QTQSQRSHDRREQQIQQQTWKP----KEDN--
-------------QHKLLAQV--QQ-EP--YSYEEYDWQSQSS-----------------
-------------------EQDH-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------CG-------EEE-YQ-----------------DWDRHSVEDQENLYEMQNWQT
HEEEQSHQTSDRQTHVDEQNQQ--------------------------------------
--RQHRQTHEENHDH---------------------------QHGRHH-EDEHNHRR---
-Q----------------------------------------------------------
------------------------------------------------------------
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---------------------------------D--------------------------
---HHQQRERQTHEEKEKYQGGQDQ-----------------------------------
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------------------------------------------------------------
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-------------------------------SRSFPNREKSHMSED--------------
----------------------DQCEGP---------QGRRFH------------PTHGG
GKSQRREKSGNHPTKPA-NYSSPLYDYVQEQAAYQY------------------------
------------------------------------------------------------
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-------------

----------------MAQLLNSILTVIKVFQKYAKENGE-CTLLCKKELKQLLLAEFGD
ILRRPND-----------PDTVETILSLLDKDRNGYVDFH-----------E-YLL-L--
-V---------------F-Q-L-A-Q-A-C-YHK----LDN---K-SYG---D-------
RISQ-QEE-EE-G-----TRDHKFPGN-RGD---SH----YGQSEGQDR-----------
-DSSNG-QSERQRRD---------------SR--------------------------YG
QSEGQDRDS--HY-GQSEEQNRDSHYGQS---------------EGQDRDSSNGQSERQR
RDSRYGQSEGQ------------DRDSCDDQRWGH-------------KSSS--SQSKRQ
G--YI-------F-------------ALNQSE------KQ------IH-----------N
SHYGQ-------------------------------------------------------
---------------IN----------Q-----QESGSYYGQSRSLDQ-ESAYGQRDRQK
LDSQYGQTDRKS------------------------------------------------
--------------------------------------------QSSLY---GQTDRQG-
--------------LGSQYGQTERQD-Q--I------S-----------HYGQIDRQGQI
-------------------S--HYG-------------------------------QT--
---DR----QGLGSQCGQTDRQG--------------------------------L----
------------------------------------------------------------
------------------------------------------------GS----------
-----QYGQTDIQG---QI-------------------------SHYGQ---T---D-RQ
GLH---------S-------------------QYGQTDRQGLGSQYGQTDR---------
------QGQTSH----YGQRDR--QGQTSH-----YGQTDRQGQTSHYGQTERQGLGSQ-
------------------------------------------------------------
------------------------------------------------------------
-------------------YGQTDRQGQISHYGQTDR-----------------------
-----------Q------------------------------------------------
------------------------------------------------------------
----------------------------GVGFQCGQTDRQGQSSHYGQTDRQGLGSQYGQ
TDR-QGQISHYGQTERQGQISHYGQTER--------------------------------
----------------QGQI-----------------SHYGQTDRHGQISHYGQPARQGQ
GSHHGHGQTDIQGQGYHYSQTERQGLSSHYGQTDRQGQGYHYGQSDRQSLSS--------
----------HYSQ------------S---EIRETGQNSYHQGSEG-TN-----------
--R-DSCVEQSGRSGRPSQQTLGQEVT-RNQGQRFQSREGQQNSHQAWEP----E-DSQ-
-----------YHQHKLIAQI--QQERP--CSYKRGDWQSCSS-----------------
-------------------EQDHIQAEARQSHGD--------------------------
------------------------------------------------------------
--------------------------G---------------------------------
------------------------------------------------------------
----HSHQA------KEEQGRQ-----------------SWGRHGCENKETPQETQARQT
HDKEQSHQGQERQTHEDEQTHQ--------------------------------------
--RRDRQTREGEQIH-Q-------------------------RQDRQTHEDEQTQQR---
------------------------------------------------------------
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-------------

----------------MTQLLNSILHIIEVFQKHAQEDGD-CASLCKKELKQLLLVEFGD
ILRRPND-----------PETVETIMNLLDRDRNGCVDFQ-----------E-YLL-L--
-V---------------F-Q-L-V-Q-A-C-HHK----LDN---R-SCA---D-------
RTSQ-REKRQE-E-----TQDHKFPGN-TGR---QH----SQRHEGKRQ-----------
-DSHHS-HSEGQDRD---------------SY--------------------------HS
QSERQGRDF--HH-GQSEKQDRTSHHSQS---------------ERQDRTSHHSQSERQD
EDYSFDQSERE------------DQDSSSGKGLSH---------------------PNRQ
G--YI-------F-------------ALNQCE------KPD---L-VQ-----------D
SRYGQ-------------------------------------------------------
---------------YE---------------------------RCGH-Q----------
------------------------------------------------------------
----------------------SSYGQSGRHGQDSCSSHTNQQESSFYY---GQSQRIDQ
ELGCSQRDRQR---LDSHCGQAKRQG-Q--T------S-----------HYGQTDRQGQT
-------------------S--HYS-------------------------------QT--
---DR----QGQTSHYGHTDRQG--------------------------------QTS--
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------LYGQ---K---D-R-
---------------------------------------QGQTSHYGQTDR---------
------QGQTSH----YGQTDR--QGQTSH-----CRQTDRQGQTSHYGQTDRQGQTSH-
------------------------------------------------------------
------------------------------------------------------------
-------------------YGQTDRPGQTSHYGQTDR-----------------------
-----------Q------------------------------------------------
---------G--------------------------------------------------
-----------------------------QTSHYGQTDRQGQTSHCGQKDRQGQTSHYGQ
TDR-PGQTS------------HYGQTDR--------------------------------
----------------QGQT-----------------SHYGQTDRQDQTSHYGQTDRQGQ
TPHY--GQTDRQGQTPHYGQTDRQGQTPHYGQTDRQGQISQYGQTDRQGQSS--------
----------PCGQSQM---------R---ETEMQKQSRYFKGTEG-KR-----------
--R-DSYVEQSGRSGRPSQQTPGQEMC-QNQGKRSQSRAVHQDSHQVWEP----EEDSQ-
-----------HHQHKLLAQI--WQEKP--LCHKERDEQSCSS-----------------
-------------------EQGHRQAQTRPSHGQ--------------------------
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--------------------------G---------------------------------
------------------------------------------------------------
----QSHWE------EKEQSHQ-----------------SWGGYSHRGLESP---WDRQT
QEDEQKYQRQDRQTHKDQQQQR--------------------------------------
--QNY----EIERYG-E-------------------------SQDQQS----QGTQR---
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-------------

----------------MSPLIRSIVDITEVFNQYASQSCD-GASLSKKDLKNLLERELGD
VLQRPHD-----------PETIDLTLELLDRDCNGRVDFN-----------E-F-L-L-F
-L---------------F-K-I-A-Q-A-C-Y--Y-A-L-D-Q-A--A--E-L------G
E-KRA-L-P-N-E-K-R-NL-S--QD-RRQ-ED-Q-R-----------------------
-------------------------------RF-------------------------EP
RSRQLDEEPG-----RRSWQKRRE----QEE--RA-EEQRLE----------QRYR----
-------------QHRD----------EEQ-R------------------LQRRELQELE
E--R------------------------------------LAEKEPLGWSKGRDAEEFSE
VEEQQR----QERQE-------LKGKGQTEER----------------------------
--------------------------------------RLQKR------RQEE-------
------------------------------------L--R-------------E--PLL-
-----R------------------------------------------------------
------------------------------------------------------------
--------------------------RDLELRREQEL-----------------------
-----------------------------------------RRE--------QELR----
---QEQRREQ---ELRREQ---------ELRQELRREQELNRRQELRREQELRREQ--EL
RQELRR-------------------------------------------------EQELR
REQE--------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
LRQELRREQELRREQE----------------------LRQE------LRREQELRREQ-
------------------------------------------------------------
------------------------ELRQELRRE---------------------------
-------------------------------------------QELRREQELRQELA---
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WQLENE-------------------------------ADARQNK---VYSR---------
PSR-QEQR-----LRQELGERQLR------------------------------------
------------------------------------------------------------
-------------------EQEEQRRDLQQERPAEE-----ARQRN--------------
-------------QWERPQRAEER----------LEQEQRFRDREEQR------------
------FR--EEKLQRAELQDS------LLD--EEQRRLQEERREPNRSRQ--LREES--
-----------QRRRTLYA-------KP------SQRQRREEELR-EERL-----LQEE-
--------------------QRQQR--ERKHRR---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------EEDLQQEE------------------------------------
-------------------------KRLQQDEEQ--------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------LQRERRRLQRERQYQEEDLQQEEER
LQQ-------------------------------EEERLQ---RE------RRRLQQERQ
Y------------------------------------QEEDLQRLRDEDQRRDLKW----
QWQPRKENEVRSNRLFTKRRGDEEPIQQLED-SQER--ERRQDRRPLQDEEE-----EKR
ELEQERRRRQQRDRQILEEEQ----FQREH---QREARRRDETFQEEEQLQGE-SR---R
RQQEREGKFLEEERQLRTERE-----------------------EQRRRQEQEREFQEE-
EEH---------------------------------LQEREKELRQECDRKSREQ-ERRQ
QRE------------------EEQLRRQERDQRFRREQERHLERE-----EEQLRDRPSR
REQERHQEREEEQLRDRPSRREQERHQEREEEQLRDRPSRREQERHQEREEEQLRDRPFR
REQERRLER----EEEQLRDRPSRREQERHQEREEEQLRDR----PSRREQ-----ERRL
EREEEQLRDRSFRREQELRRDRK--------FHEEEERREELEEE-----QRG-QERDRL
RV--------E-EQL-RGQR--------------E-------------EEQRRRQECDR-
------------------------------------------------------------
-----KLHRE--------------------------------------------------
-----------------------LEVRQ-----ELEEERLRDRKLRREQELRRDRKFHEE
EERRHEEFE-----EKQLRLQEPDRRFRREQELRQECVEE--E--RLRDSKIRREQELR-
--REREEERLRDRKIRRDQELRQGLEEEQLRRQELDRKFREEQELDQELEEER-----LR
DRKIRREQELRREQEL-------RREQEFRREQELRREQEFRREQELR-----QEREEER
LRDRKIRRDQ-ELRQGLEEEQLRRQERDRKVREEQELDQELEEERLRDRKIRR---EQEL
RREQELRREQE-------------------FRREQ------------------------G
LRRER----EEERLRDRKIRRDQELRQGL--EEEQLRRQERD------------------
-------------RKFREEQELGQELEEERLRDRKIRREQELRRE------REQEQRRRL
EREEEQQRLHEREEEQRRRQERE-QEQQRCLEREEEQFR--FEEQQRRRQEREQQLRQER
DRRVLEEEELRQEREE---LLHRQVGG-RKFREEERLRLEREE-------QQRRLQERDN
RRFREEVELRQEREGQQLRQ---ERDRKFREVEELRQ-----------------------
---------EE-QRRRQERDRKFREEKHPR--EEREEQQL----RREKRDGQYLAEE---
-----------QFARDTIRRQ-EQELRQEEEQRRRQERERKFQEEQ-IRR----------
-----------------------------RQEEQRRRQILE-----PGTRQFANVPV---
-------------------RSSPLYEYIQEQRSQYRP-----------------------
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-------------

----------------MAQLLSSILSVIDVFHKYAKENGD-CTLLCKEELKQLLLAEFGD
ILQRPND-----------PETVETILNLLDQDQDGHVDFH-----------E-YLL-L--
-V---------------F-Q-L-V-Q-A-C-YRK----LDN---K-SYG---G-------
RISQ-QERGQE-G-----AQDRKFPGN-TGT---QH----RQRHEEERQ-----------
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QPERQDRDS--HHDHQPERQDRDSHHSQP---------------GRQDRDSHHNQSEKQD
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G--HI-------F-------------ALNGCE------KP------VQ-----------D
SHYGQ-------------------------------------------------------
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ELGCGQTDRQD---QSYHYGQTDRQD-Q--S------S-----------HYGQMDRQGQS
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-----------------------------------QRQSYHYGQTDREGQSS--------
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-----------HHQYKLLAHI--QQERP--RCHKGRDWQSCSN-----------------
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-------------

----------------MAQLLSSILSVIEVFHKYAKENGD-CALLCKEELKQLLLAEFGD
ILQRPND-----------PETVETILNLLDQDRDGHVDFH-----------E-YLL-L--
-V---------------F-Q-L-V-Q-A-C-YRK----LDN---K-SYG---G-------
RTSQ-QERGQE-G-----AQDHKFPGN-TGT---QH----RQRHEEERQ-----------
-NSHHS-QSERQDRD---------------SH--------------------------SG
QPERQDRDS--HH-GQAERQDRDSHHGQP---------------ERQDRDSHHSQPERQD
RDSH-----HS------------HQDSNSG------SDKK---VSHK--STR--GQTKWQ
G--HI-------F-------------ALNGCE------KP------VQ-----------D
SHYGQ-------------------------------------------------------
---------------SE---------------------------RLAQ-Q----------
------------------------------------------------------------
----------------------P-----ETFGQDSHFNQTNQQKSGSYC---GQSGRLGQ
EFGCGQMDRQD---QSYHYGQTDRQD-Q--S------S-----------HYSQMDRQGQS
-------------------S--HYS-------------------------------QT--
---DR----QGQSSHYNQMDRQG-------------------------------------
------------------------------------------------------------
-----------------------------------------------QSSH---------
------YGQTNRQG---QCYQYGQTDRQGQSSHY-SQPDRQGQSFHYGQ---T---H-R-
---------------------------------------QGQSSHYGQTDR---------
------QGQSSH----YGQTDR--QGQSSH-----YGQMDRQGQSSHYGQTDRQGQSSH-
------------------------------------------------------------
------------------------------------------------------------
-------------------YGQTDRQSQSPHYGQTNR-----------------------
-----------Q------------------------------------------------
---------G--------------------------------------------------
---------------------------Q--SSHYGQTDRQGQSSHYGQTDRQGQSSHYGQ
TDR-QGQSS------------HYGQTDR--------------------------------
----------------QGQS-----------------SHYGQTNRQGQSSHYGQTDRQGQ
SSHY--GQMDRQGQSYHYGQTDRQGQSSHCGQTDRQSQSYHYGQTDRQGQSS--------
----------CYVQSQT---------G---EI--QGQNKYFQGTEG-TR-----------
--K-ASYVEQSGRSGRLSQQTPGQKGY-QNQGQGFQSRDSQENIHQVWEP----EEDSQ-
-----------HHQHKLLAHI--QQERP--LCHKGRDWQSCSN-----------------
-------------------EQGHRQAKTRQSHGE--------------------------
------------------------------------------------------------
--------------------------G---------------------------------
------------------------------------------------------------
----QSHWA------EEEQGHQ-----------------SWDRHSHEGQEGPCGTQDRQT
PEDEQNHQRRDRQTHEDEQNHQ--------------------------------------
--RQDRQTHEDEQNR-Q-------------------------RRDRQTYEDEQNHER---
------------------------------------------------------------
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-------------

----------------MSQLLRNINGIIEAFRRYARTEGS-CTALTRGELKRLLEQEFAD
VIVKPHD-----------PATVDEVLRLLDEDHTGTVEFK-----------E-FLV-L--
-V---------------F-K-V-A-Q-A-C-FKT----LSESP-EGACS---S-----QE
SGSL-----HS-G----AWQELNE-GQRSGTEV--GRVGKGQHYEG--------------
-------SS-------------------------------------------------HG
QSEQP-----------SRGQNR---------------PGAQTQG----------------
------------------------QATGSAWVSSYDR------------------QAESQ
SQERT-SPQTQRSRHTEQTQRAGEGKRHQTTE------M--------------R-----P
ERQP-----QTREQDRTHQTDETV-TGSG-------------------------------
--------------------------------------------TQTQA--GATQTVEQD
SSHQTGRTSTQTQKATNDQNRGT----------------E--------------------
-----IHGQDRSQTSQ-----AVTGGHAQTQ-------------AGSHTQIPTH------
------------------------------------------------------------
------------------------------------------------------------
----------------------T--------------VEQDSSQ--------------QT
GRTSTQTQEATNDQNRGTEI----------------------------HSQGRSQTSQAV
TGH-AQIQAGTHT-----------------------------------------------
------------------------------------------------------------
---QTPTQTVEQDSSH----------------QTESTSTQTQGSTNDQNRGTEIHGQGRS
Q---------------TSQAMT---GG--HA----------QTQAGSHTQTV--------
-----------------------------------------E------------------
------------------------------------------------------------
----------------------QDTSQTVSHGGAGE------------------------
---------------------------------------------------QGQTQ----
TQPGSGQKWTQVSNPEA-GE----------------------------------------
---------TVPG-------------------------GQAQTGASTESGRQEWSSTHPK
HYV----------TEGQG-----------------------DIQPT--------------
-------VVGEEWVDDHSRET---AIFRLDQGN----LRT--------------------
------------------SVSSAQCQDAAQ------------PE-EKRGIT-ARE-----
----------L--------------------------YSYLRSNKP--------------
------------------------------------------------------------
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-------------

----------------MPRLLRDVLCVIETFHKYASEDSN-GATLTGRELKQLLQGEFGD
FFQPCV------------LHAVEKNSNLLNIDNNGIISFD-----------E-FVL-A--
-I---------------F-N-L-L-N-L-C-YLD----IQL-----LLS---S-ELRQ--
-VTKP-EKEKPDD------VDLQATT---GD---------GQWTAG---TSPT-------
-----------QEER----------------MLPS----------------------GMA
SLSQLIPEES----------------GAVGNNRVD-PWREAKTHNFPGEASEYNDP----
---KNQHL-------------------------------------------------EGD
-------EQIQEVAQDVQTTEDNEGQ-LKANK---PMARSKQTSSPTK-RKG-QDKKISQ
EGD-EP----VREQSVS------KIRDHF---------------GEQEGNLE--------
--------------------------------------------PQNSPPEEETQRPSE-
-----------------DQ----------EVRTEK-E--K----------YSNTQEPPL-
------Q------------------GEDE-P-------------SSERA---DLP-----
EQAAARTLSQTQ---KSTDPEDV--CRT----FDTQDPGKDAD------------QTPAE
------------TTN--SGEPEDYGR---------------------TSETQE-------
------------------------------------------------------------
------------------------------------------------------------
------------------KESETKDLPVQGGSRNG----SETPDMR--------DERKER
RGPETHETAGQ-KE--------------------RDR---------------------KT
QPLVL-------------ETQTQDGQY--QEFQGLS-------KSKDAKKDSET------
-----------------------------------------QYLSSEGGDQT-----HPE
L--------------E-------GT----A-VSGGEAEHTKEGTTEAFVNRKNAPAAART
LGARE----------STQD-----------------------------------------
--------------------------------------------LAPLEK-QSAGENSRA
TKTHDK--PVEEEDGYQ-----------------------------------GEDSESPF
TQNDEGSSETPSSLASEEDNSSSETG---------------E------------------
--------LPMQGDSK------------------SQGDPHGGSV---------QGGHNNN
PDT---------------------------------------------------------
------------------------------------------------------------
---------------------------------------------QRQGTPGEKNRAQEA
V------VPAVR------------------------------------------------
-GEDVQLTDDQEQPSRGEHK-Y--------QGPG-----T-KGPGAAVEPSGHPEAQ---
---ESTAGD--KNRKSLEIEITGALDED--FTDQLSLMQLPGKED---------------
-------------------SRNELKVQGPSSKEEKGRATEAQNTMLKSLDEDNSASH---
--KIQLETKE-------TVTS-EEEDESPQELAGEGGDQTSPAKK-EDNSSVPWPSLEKQ
VQRDQEPCSVERGAIHSSPLYQYLQEKILQQTNITQE--------------------DHQ
K---------------------------------QVQIAQASGPE---------LCS---
-VSLTSETSDFSVFFNYSQASQ---------------PYTRGLPFDESPAGA---PSPQA
LEDKQDYPQRERLVPQREASTT----------------------------------K---
-----------------------------Q------------------------------
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-------------

----------------MPQLLRNINGIIDAFQRYARTEGN-CMVLSRGELKRLLEQEFAD
VIV KPHD-----------PA TVDQVLRLLDEDHTGTVEFK-----------E-FLV-L--
-V---------------F-K-V-A-Q-A-C-FKT----LSEGP-EGACG---P-----QE
SGSF-----PR-G----ASAELGE-GQRSVTEV--GGGGKGQRHEG--------------
-------SS-------------------------------------------------GG
QGRQA-----------SRGQDG---------------AGAHTQG----------------
------------------------PDISSSQVSHQEV------------------QHASQ
RQERE-SQQTQARGHVEP------NQSHQTSE------W--------------V-----S
ERQS-----QTREQNRAHQTRGTV-TGTV-------------------------------
--------------------------------------------TQTQT--GATQTTEWD
RSHQTGSTSTQSQEPTYGQTRGT----------------E--------------------
-----THSQDRSQMSQ-----VATGGHVQTQ-------------TGSHT-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------QQGRGH----------------QTGSTSTQSQESTYGQTRGTETHSQDRS
Q---------------MSQVAT---GG--HV----------QTQTGSHTQTT--------
-----------------------------------------Q------------------
------------------------------------------------------------
----------------------QDR----SQTGARG------------------------
---------------------------------------------------QGQTQ----
TQS---------GSCEA-EE----------------------------------------
---------TVPG-------------------------GQAQAGTSTPTGTQDGSSTHPG
SSG----------TGGQD-----------------------EREPL--------------
--------VKEEWVDDQTRDT---VIGRQDQGS----LHT--------------------
----------------------------AQ------------PE-GKRELT-ARG-----
----------L--------------------------YSYFTSNKP--------------
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-------------

----------------MPQLLGNIDGIIQAFSRYARTEGD-CTTLTRGELKLL--EELTD
VIV KPHD-----------PA TVDEVFRLLDEDSKGTVDFK-----------E-FLV-L--
-V---------------F-K-V-A-Q-A-C-YKT----LNESP-EGACG---T-----QE
TGNQ-----HP-G----STQQTRS-DQSSHTGT--GRVEREQNRHR--------------
-------HA---------------------------------------------------
GEEQT-----------FPGQNR--------P-------GTQTQG----------------
------------------------QDFTSTQVCVQDK------------------QPETQ
GQERG-STDTKTDGS--------------------------------------------Q
SDRP-----QTREQGRTHQTGETV-TGCH-------------------------------
--------------------------------------------SQ--T--GTTQIREEG
RSHQIGETVT--------------------------------------------------
------------------------GRQSQIH-------------TGT-----TQTREQGR
THQ---------------------------------------------------------
------------------TGEIVTGG----------------------------------
-------QSQIHTGT-----TQI--------------REEGSTH--------------QT
GET--------------------------------------------------------V
SGGQSQIHTGTTQIRE-----Q-------------------------GSTH---------
-------QTGE------TVSG-GQS-----------------------------------
QIHTGTTQIREEGRSR----------------R---------------------------
-------------------DSD---WG--QS----------QIHTGT-TQIR--------
-----------------------------------------E------------------
------------------------------------------------------------
----------------------QGSTHQTGE-TVT-------------------------
------------------------------------------------------------
---GCHSQ----------------------------------------------------
-------------------------------------------TGTLQITERQESGSQTS
CSV----------TGGLQ-----------------------ESVDCQG------------
---QESTIGGQQWNRHQTSE--------QDQSN----LQM--------------------
------------------RESKVHGQKATQL-------------GGKRGLI-AQG-----
----------L--------------------------YSYFKGNKHTC------------
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-------------

----------------MAQLLSSILTVIKVFQKHASENGD-CTSLCKKELKQLLLAEFGD
ILRRPND-----------PETVETILTILDRDSNGHIDFH-----------E-YLL-L--
-V---------------F-Q-L-A-Q-A-C-YHK----LDI---Q-SCG---D-------
RTSQ-QEEEQE-G-----VQDHTFPRN-RGR---QH----RQRHEEERQ-----------
-HSHHG-HSERQDRD---------------------------------------------
-----------------------SHHSGSERQERD---SSYGQSERQDQDSYYDQSERQE
RDSHYGQSERQGW------------DSG--------------------------------
---------------------------ISLCL------KSNVKNQ-FK-----------D
SHHNQ-------------------------------------------------------
------------------------------------------------------------
---------------------SE-------------------------------------
-----------------SLGHDQSCGQSRRLGQDSCSSHTEHQQTGCIY---GQSGRLDQ
ESGCGQKHRQG---LDSEYGQTDRQA-D--K-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------AQSSHYGQTDR---------
------PGQISH----YGQTDR--QAQSSR-----YGQADSRAQSSHYGQTDRQAQSSH-
------------------------------------------------------------
------------------------------------------------------------
-------------------YVQRDRQGHSSPCGQANR-----------------------
-----------R------------------------------------------------
---------G--------------------------------------------------
-----------------------------QSSCYGQRDRQGHSSRYGQADRRGKSSHYGQ
TDR-QDQSSRYGQTDRQGHSSHCGQTDG--------------------------------
----------------PGQS-----------------SHYGQTDRQ--------------
------------DQSSRYGQADRRGQSSHYGQTDRQGQSSHDGQTDKEVHSS--------
----------HYGQTET---------G---ETEIQGQDRYFQGTEG-TR-----------
--R-DTYVEQSGRSGRLSQQTQGQEVN-RNQRQ------GSQNRQQAWKRQ--L-EDTQ-
-----------HHQHKLLAQI--QQERS--LCHKGRDWQSSGS-----------------
-------------------EQGHRQAETQQSHS---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------QTETRDRQS
HEDEQNRQRQDRQTHEDEQNHQ--------------------------------------
--RQDRQTHEDEQNH-Q-------------------------RQDWQTHEGEQDHQRQDR
QTHEDE-------QNR--------------------------------------------
------------QRQDRQTHEGEQNRQRQ-----------D-------------------
--------------------------------RQTHEGEQNHQR----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----Q----------------------------DWRTHEGEQNRQRQDRQT--------
--------------------HEGEQNRQRQDRQTHEGEQNRQ------------------
-------------RQDRQTHEGEQNRQRQ--------------------------DRQTH
E----------GEQNRQRGNRQIHEEDQ--------------------------------
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-------------

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------------------------------------------MSTIMEN-----------
--------IIAIIKAFQEYSHGDDNNETLNEKELKELLEIELGPILKN-PDDPDTAEIIM
DILDLDHNKRIDFSEFL-------------------------------------------
---------------------LMVFRLTRALYVN--------------------------
-----------------------------------------------SKRENTQAGSRKE
KSNGHQRKETDEESEDEEDGKK-----------KRKTTTSGKSDKEEYKARPKSTGERDK
HGCRSRSRSQ-GR---------------KGGISTRGPREVQDKKHQRSPRKNKK------
---------------------------------------------------ESNITKKGG
EKH-NMFMSPA-----------REDRRKEEESENERRRESASTRGGREAHGRGQSQENVR
HPAQAGSPGQREPSRGHSQ-----------------------------------------
------------------------------------------------------------
---------SDTGRSPQSQQEHSGHSSRHPAHGHGPSTAPP----QPGRPGRSSQSQESD
SEGNSEDSEAQSESGSEHQ--------------HGAAHGQARDS----------------
-----------------SAHSVPHGGHGAQHG-------------------SQGHSPDGS
RPSGSRHGRPASHQHAQSSHAAPRTSAEGRPQSHPQHSGDSARHSGPGHQQSPWASDPQR
HRGPSASQESDAEQHSHHSHTQSGSGSGS-------------------------------
--REPASTRGGRQAHGRGQSQDNVRHPAQAGSPGQ----REPSRGHSQSDTGRSPQSQQE
HSGHSSRHPAH--GHGPST------------------APPQPGR--PGRSSQSQDTHQNG
SRPSGSRHGRPASHQHP--QSSQAAPRTSAGR----------------------RPESHP
QHSGDSARHS--------------------------------------------GSGHQQ
SPWASDPQRHRGLVLA-------------RQSGSGSGSHPTSRPSHPRHSSRPSGDPQGP
QAHHGQSDSAQREPASTRGGRQAHGRGQSQDNVRHPAQARSPGQRQPSQGHSQSDTGRSP
QSQQEHSGRSSRHPAHGHGPSTAPPQPGRPGRSSQSQESDSEGHSEDSEAQSE-------
------------------------------------------------------------
---------SGSEHQHGAAHGQARDSSAHSAPHAGHGAEHGRSDSASGRPGSQAAGRQGS
RQGHSPDGSRPSGSRHG-------------------------------------------
------------------------------RPASHQHPQSSHAAPRTSTGGRPRSHPQHS
GDSARHSGPGH---------------QQSPWA-SDPQRHRGPSASQESDAEQHSHHSHTQ
SGSGSGS------HPTSSPSHPRHSSR---------------------------------
-----------------------------------------PSGDPQGPQAHHGQSDSAQ
REPASTRGGRQAHGRGQSQDNVRHPAEAGSPGQREPS----RGHSQSDTG----RS---P
QSQQE-HSGR-------SSRHPAHGHGP--------------------------------
-----STAPPQPGRPGRSSQSQESDSEGHSE---------------D-------------
----------------------SEAQSESGSEHQHGAAHGQARDSSAHSAPHGRHGAQHG
RSDSALGRPGSQAAGRQGSRQGHSPDGSRPSGSRHGRPASHQHPQSSHAALRTSTGGRPQ
THPQHSGD-----SARHSGPGHQQSPWASD------------------------------
------------------------------------------------------------
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----------------MTDLLRSVVTVIDIFYKYTKEDGE-CGTLSKNELKELLEKEFRP
ILKNPDD-----------PDTVDVIMHMLDQDHNRRLDFT-----------E-FLL-M--
-V---------------F-K-L-A-M-A-C-NKV----LSK---Q-YCK---A-------
SGSKKHRHGHQ----------CQEEENETEEE--------EE-------ETPE-----QK
SGYRHPSWSER-EEHGHS---SGGSRGTVKHRHGS-----------------------N-
-SWRLRRQD------------------------DLCSSRNLKGSE-KRRHGSSS------
---------------------------GYSWS--------S--SEERHGSSS-GEMGERR
N--------------------------KSYV-------------STSR----ES-----G
KEYESG-------------------YG---------------------------------
--------------------------------------------SKSQGKKGHGGLSHGL
ETS--EH-----E-SNSS---------QLKKSREEKLGSI-----SGGSGDCKRQSHACG
SS---------------------------------------------------------N
SGGCGRS---QN---ASTSYHASRSGGQ--------QSCCQSGSSGGQGHRCVSGGQSSG
YCH-----PESSSCS-QSSSQRGCGS----------------------RKCGQ--SQNC-
GTQQRRG--SSQPSCCRQH-----------------------------------------
-----------------------------------------------G-------F----
-GASQSSSSSQY-----------GSGSR-GYTSNCHQRGSGSSEYS--------------
---NC--------S--QHEFSSGQT------C-SHEK-----------------------
---------------------------------------HGRGQ----H-----------
---GSGSGQ-SC----CSQHSS---GS---------------SQSSACGRH---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------RSGSGQS-
------------SGFGE-HGSGSGQ-----------------------------------
-----SSGFGQHRSGSAQSSGFGQHG-----------SGPGQSSGFGQHGS---------
G-----------------------------------------------------------
-------------SGQSSGFGQH---G----------S------GSGQSSGSG-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------QH-----GS------------------
------------------GPGQSSG-----------------------------------
------------------------FGQHGSG------SGQSSG-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------SGQH-----------------------
-------GSGPGQSSGFGQHES-GP-G-QSS-------------------GSGQHG-SGS
G-----------------------------------------------------------
--------------------QSSGFGQHGSAS----GQS----------S---------G
FGQHG-SRS-GQ--SSGFG-QHG-SGSGQY---SSSGQHGSGP--GQSS-----------
--------------------------------G-F-------------------------
------------------------------------------------------------
-------G--------------------------QH-GSG--------SG-QSSGF----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------GQHG--------SRSG-QSSGF--GQHGS------
-------GSG------------QYSSSGQHGSGSGQSSGFGQHGF-GSG-QSS-GF---G
QH-GS-GS-GQYSGS-G-QHGS-GP-GQ-SS------------------------GFGQH
-GSGSGQ---------SSGFGQHGSQSGQSSGFGQHGSGSGQSSG--------S------
---------------------GQHGSGPGQSSGFGQQGSGSGQL-SGSGQHRSGPGQSSG
FGQHRSGSGQPSGFGQHGSGS------------------------GQYSGSGHH------
GSRSGQS-----------------SGFGQ---HGSGS------------------G----
----------QSSGFGQHGSG---------SGQSSG------------------------
------------------------------------------------------------
-----SGQ------HGS----GPGQ----S------------------------------
----------------------------SGFG----------------QHRS-------R
S------G----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------QS--S
G-FGQ-H-----------GS-GSGQYS---------------------------------
---SSGQHGSG-SG--Q--STGF-GQ-------------HGF---GS---GQSSGFG-QH
GSGSG--QYSSGFGQHGSGSGQSSGFGQHR-SGSG--------QSS-GFGQHGSG--SGQ
SSGFGQHGSGSGQSSG------------FGQYESESGQSSGFGQHGSGYGQSSGFGQHES
GYGQSSGFG--------------QHESGSEQSSGFGQHESESGQSSGFGQHESESGQ---
-------------------SYGFGQHGSGSGQY---------SGSGQHGTGSRS---S--
------------------------------------------------------------
------GFGQHGSGSGQSSGIGQHESG-----SSGQ------------GTQRTTQQQS--
--RDTSRS------EQSSRG---------------QSSHTVPHSTRRRG-SVHTESSERE
EHSGVSH----RHTGSHQGQAGSQQGESGSS-----------------------------
------------------GQGTQRTTQRQS-----------------------RDTSRSE
QSSRGQSSHTVPHSTRRRGSVHTESSEREEHSGVSHR---------HTGS--HQGQAGSQ
QGESGSSG----------------------------------------------------
-----------------------QGTQRTTQWQSRDTSRSE-------------------
------------------------------------------------------------
---------QSSRGQSSHTVPH--STRRRGSVHTES-SESEEHSGVSHRHT--GSHQGQA
GSQQGESGS--SGQGTQRTTQRQSRDTSRS----EQS---SRGQSSHTVPHSTGRRG-SV
HTESSESEEHS-----------------------------------------GVSHRHTG
SHQGQAGSQQGESGSSGQGTQRTTQRQSRDTSRSE---------------------QSSR
GQSSHT-AHSTGRRGSVHTESSESEEHSGVSHRHT--GSHQGQAGSQQGESGSSGQGTQR
TTQRQS-------------------------------------------------RDTSR
SEQSS---------------RGQSSHTVPDSTGRRGS-----------------------
------------------------------------------------------------
-VHTESSESEEHSGVSHRHTG-----S-HQGQAGSQQVSPDLASSAKHGSSHGRSQDTQG
QYGS----STNEK-------------------------SERQG-----GQG-ARHAQSAD
SSTH-----------------------------SGTGHGQSSRASGGHGHRH------GR
SGS------GSRGRQGS-RHEQAQDSSRHAAPHGDHASSRGQSASSSGGRQGSRHEQAED
TSGRSGSQHRQ-------------------------------------------------
---------------------------TAPQGRSDSAHGRSGARGESTPRSGHGQAADGP
RQDSESEGHSEDSERQA-----------------------------------------GG
QRA----------PAHGVSRDSSG---HS----------------RSQQRERTRGQHAES
AQGPSAAGSTGRHGESHGQSLDSPRQSGSQHTQAE-----TSQAES--------------
-------------------------SPSSRRSRRHEQSPDSAGH--ASDSEAHAEH----
-------------------------------S-GRQATRTQGRS----GSHAREQQAPPR
GQTADSSRHAGEQQAQTSRHR------SERQGGQGAR-----HAQSADSSTHS-GTGHGQ
SS------------RASGGH----------------------------------------
--GHRHSSVSQGRSG---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------SGSRGRQGSRHEQAQDSSRHAAPHGDHASSRGQS-------ASSSGGRQGS
RHEQAEDTSGR-SGS-QHR-----------------------------------------
----QTAPQGRSDSA-------HGRSGARGESTPRSGHGQAADGPRQSGSRRQQTATGT-
-DSSRHAQSPQ---------------QGHAAAGPATSRRRGSSVSQDSESEGHSEDSER-
------------------------------------------------------------
--------------------------------------------------QAGGQRAPAH
GVSRSERQGGQGARHAQSADSSTHSGTGHGQSSRAS-----G-GHG--------------
------------------------------------------------------------
--------------HRHSSVSQASDSEGQSV-DSESESASEHGRSAD-------------
----------------------SQGRSGSGSRGRQGSRHEQAQDSSRHAAPHGDHASSRG
QSAS-------SSGGRQGSRHE------------Q-------------------------
-----------------------------------------AEDTSGRSGS---------
-----------------QH---RQTAPQGRSDSAHGRSG----ARGESTPRSGHGQAADG
PRQSGSRR-QQTATGTDSS--R--HYGANNSHSVISERALYGSGVGWR---HGSYGSAD-
-------------------------------YEYGQSWFGHS------------------
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----------------------------------------------------MKARRSVT
TQGRSGSTSRNQRGSSHGQAGDTSRRSESRHGQADSHRQRESVHGDSGSRTSHGQGSRHE
QSRDSSRRSGT--GHGQSS---TGSGSRRHRESSVSQASDSE GY--SGDEARRSVTTQG-
RSGSTSRNQRGSSHGQAGDTSRRSESRHGQADSHRQRESV HGDS----GSRTSHGQGSRH
EQSRDSSRRS--------------------------------------------GTGHGQ
SSTGSGSRRHRESSVSQASDSE GYSGDE--------------------------------
---ARRSV----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--TTQGRSGSTSRNQRGSSHGQAGDTSRRSESRHGQADSHRQ------------------
------------------------------------------------------------
-------------------------------------RESV HGDSGSRTSHGQGSRHEQS
RDSSRRSGTGH---------------GQSS-TGSGSRRHRESSVSQASDSE GYSGDEARR
S-----------------------------------------------------------
--------------------------------------------------------VTTQ
GRSGSTSRNQRGSSHGQAGDTSRRSESRHGQADSHRQRESV HGDSGSRTS----HG---Q
GSRHE-QSRDS-------SRRSGTGHGQ--------------------------------
-----SSTGSGSRRHRESSVSQASDSEGYSG-DEARRSV-------T-------------
----------------------TQGRSGSTSRNQRGSSHGQAGDTSRRSESRHGQADSHR
QRESVHGDSGSRTSHGQGSRHEQSRDS---------------------------------
---------------------------------------------SRRSGTGHGQSSTGS
GRYSGDE-------------ARRSVTT-------QGRSG----STSRNQRGSSHGQAGDT
SRRSESRHGQADSHRQSES-------------------------------VHGDSGPSSF
PEEV---------------------------GPYEQSGNRY-------------------
------------------------------------------------------------
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-------------

----------------------SICDITEIFNQYVSHDCD-GAALTKKDLKNLLEREFGA
VLRRPHD-----------PKTVDLILELLDRDRNGRVDFN-----------E-F-L-L-F
-I---------------F-K-V-A-Q-A-C-Y--Y-A-L-G-Q-A-TG--L-D------E
E-KRA-R-C-D-G-K-E-SL-L--QD-RRQEDD-Q-R-----------------------
-------------------------------RF-------------------------ES
RDRQLEEEPG-----QRRRQKRQE----EER--EL-AEG-EEQSEKQE-RLQQRDR----
--------------QRR---------DEELWR------------------Q-RRERREQE
E--R----------------RAEEEQ-LQRCK-------------------GHETEAFPD
EE-QQR----RRELQ---------------------E---LRRECREEKQQQRR------
-------------E------------------R--QERVLQEEEEKEW-RKRERVHRQEE
-----------------------------K------LQEE-------------E--PQL-
-----QRELQE-EEEQL--------QKLERQ---------------------ELKRERQA
EE----Q--QQQ---RLRREQ--------QL-RREQEEERR-----EQ---EERGEQR--
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------LKREQ--EERREQQERREQ--RL
KRE-------EE-----------ERRDW--------LKREEEKERRE---------ERLK
SEQEE--------E--RR----EHW------L-KCEEEEKRREQE------RR------E
QR-LK-RQEEEERREQRLKRQEEEERR-EQ-LLKREEERLQQERR-------------EQ
W--LKREQ-------------E---ERREQWLKREQEEERRDQL------LKREEEEKRR
QQEERREQRLKRQEEE--------ERREQLLKREEEERLEQEERREQRLKREQEERREQ-
--------------------RLKREQEE----------------------------RREQ
RLKRE-QE-ERREQLLKREE-EEERLEQEERR--EQRLKR-EQEERR-EQEE--------
----------RREQRLKREEEERLEQEKR-R-E-QLE-ERRQ-QWLRR----EQEL----
---------------A--EE---EQE---------------QA-----RERIKSQTPKWQ
WQLESE-------------------------------ADARQSK---VYSR---------
PRK-QEGQ-----RRRQEQEEKRR------------------------------------
-------------------RRER---E----------L---------QW---Q-------
----------EEEQARRQQQEEEQRRDFTWQWQAEE-----ERQRGRQRLS---------
-----A-RPSLREQRERQLRAEER----------QQREQRFLQEEEEKEQRRR--QRRE-
RERELQFLEEEEQLQRRERAQQLQEEGYGPQEDQERRRSPEQRRDQKWRWQ--LEEER--
-K---------RRHYTVYA-------KP------ALRGQLRKEQQ----L-----QQQE-
------E-EELQ--REE-REKRRRQEQERQYREE-EQL-QQEEEQLLREE----------
-REKRR-RQERERQYREDEEL-QQEEEQLLG--------------EE-------------
---------REKRRR-RERERQYRKEEELQQ-------------------------EEEQ
LLR---------EE-REKRRRQEQKREYRKEEELQQEEEQLLREERE---------KRSL
-QERERQYRKEEELQQEEE--QLLREEREKRRLERERR-YREE-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------EEL---QQEEKQL---LREE------------------
------------------------------------REKRRRQELERQYREEEELQ----
--Q-------------------------------EEEQLL---RE--EQEK-RRQEPERQ
Y-----------------------------LEEEELQHQERKRRYRDEDQRRDLKW----
QWEPEKENAVRNNRVYCKRRENE-QFRQSED-SQVRDRQSQQDLQPLLDEPQ------ER
GGKQEKRRWQQRDRHFPEEEQ----LERE--EQKE-AKRRDRKFQEEKQLLRE--EKEKR
VRQGRDRRFREEEQLLQE-----------------------REEQQLSRQERDRKFREEE
LR---------RQERERKFLEE---------EQQLRRQELEQQLRHDRDRKFREEEQLLQ
ERE------------------EQQLRR---------------------------------
----------------------------------------------------QERDRKFL
EEEQ--------QLRQ--------------------------------------------
------DRDRKFREEEQLLQEREEQQLRRQ------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------ERDRKFLEE
EQQLRRQEE-----------EQQ-------------------------------------
------------------------------------------------------------
-------------------LRRQERDRKFLEEEQQ------------LKFLEEEQQLRRQ
ERDRKFREEE---------QQLRPQELERKFLQEE--------QQLRR------------
------------------------QELERKFREEEQ--------------------LRQE
T---DE-EQLRRQERDRKFLEEEQLRQER--EEQQLRRQERNKKFREEEQQLRQ------
EREEQQLRRQERDRKFREEEQ-------------------QLRRQERDRK---------F
--LEQQ--------L--RRQEL------ERKFLEEEQLRQETEEEQLHRQERDR------
--KFLEEEQLRQEREE-Q-QLRRQERDR-KFREEEQLRQEREE-------QQLRRQER-D
RKFREEEQLPQEREEQ--QLRRQDRDRKYRWEEEQLQL----KKQE--------------
------------------------------------EQRLRQE-----RDGQYRAEE---
-----------QFATQEKSRRQAQELWQEEEQKRRQERERKLREDH-LRSQQEEEQRRR-
-----Q----V------RET--------QSQEGKGHGRLLE-----PGSHQFASVPV---
-------------------RSSPLYEYIQEQKSQYRP-----------------------
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-------------

----------------MTDLLRSVVTVIDVFYKYTKQDGE-CGTLSKDELKELLEKEFHP
VLKNPDD-----------PDTVDVIMHMLDRDHDRRLDFT-----------E-FLL-M--
-I---------------F-K-L-T-M-A-C-NKV----LSK---E-YCK---A-------
SGSKKHRHS---------------------------------------------------
------SW----------------------------------------------------
-----RRQG------------------------HLSSSGNQERSQ-KRYHR---------
---------------------------------------------------------ERI
N--------------------------KSHV-------------SPSR----EF-----G
EEYESG-------------------SG---------------------------------
--------------------------------------------SKSWERKGHGGLSCGL
EIS--GH-----E-SNST---------QSRSS-GQKLGSS-----RSCSGD--------S
RS---------------------------------------------------------N
SSGCGRP---QN---ASNSCQSHRFGGQVNQSSYI-QSGCQSGINGEQGHDCVSGGQPSG
CGQ-----PESNSCS-QSYSQRGYGA----------------------RENGQ--PQNC-
GGQQRTG--SSQSSFCGQY-----------------------------------------
-----------------------------------------------E-------S----
-GGSQSCSNGQH-----------EHGSC-GRFSNSSS----SNEFS--------------
---KC--------G--KHRSGSGQF------T-SCEQ-----------------------
---------------------------------------HGTGL----S-----------
---QSSG---------FEQQVA---G-----------------SSQTCSQY---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------GSRSSQS-
------------SGYDE-HGSSSGK-----------------------------------
-----TSGFGQHRSGSGHSSGFGQHG-----------SGSGQSFGFGQH-----------
------------------------------------------------------------
--------------------------G----------S------GSGQSSGFG-------
----------QH-ES-------RSC-----------------------------------
-----------------------QS-S-----Y---------GQHGSGS-----------
------------------------------------------------------------
-SQSSGYGQ--HA---------------------S-------------------------
----------------------------------R-------------------------
---------------------------QTSGFGQH-----GL------------------
------------------GSGQSTG-----------------------------------
------------------------FGQYGSG------SGQSSG-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------FGQH-----------------------
-------GSGSGQSSGFGQHES-RS-G-QSS--------------------YGQHS-SSS
SQSSG-YGQHG-------------------------------------------------
------------------SRQTSGFGQHGSGS----GQS----------T---------G
FGQYG-SSL-GQ--SSGFG-QHG-SGSGQS---SGFGQHESTS--GQS------------
--------------------------------S-Y-------------------------
------------------------------------------------------------
-------G--------------------------QH-GFG--------SS-QSSGC----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------GQHG--------LSSG-QTSGF--GQHEL------
-------SSG------------QSSSFGQHGSGSGQSSGFRQHES-GSG-QSS-GF---G
QH-ES-RS-HQ-SSY-G-PHGS-GS-GQ-SS----------GYG-QH-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------GSS---------SGQTSG------------------------
------------------------------------------------------------
-----FGQ------QGS----SSSQ----Y------------------------------
----------------------------SGFG----------------QHGS-------G
L------G----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------QS--S
G-FGQ-H-----------GT-GSGQFSGFGQHES-RSHQSS-YGQHGS-GSSQ-SS----
---GYGQHGSS-SG--H--TTGF-GQ-------------HRS---SS---GQYSGFG-QH
GSGLG---QSSGFGQHGTGSGQSSGFGQHE-SRSH--------QS--SYGQHGSG--SSQ
SSSYGQHGSSSGQTSG------------FGQHRSGSGQSSGFGQYGLGSGQSSGFGQHGS
GTGQSSGFA--------------RHEYRSGQ-SSYGQHGTGSSQSSGCGQRESGSGP---
-------------------TTGFGQHVSGSDNF---------SSSGQHISGSDQSTG---
------------------------------------------------------------
-------FGQYGSGSGQSTGLGQVESQQVASGSTVH------------GRQETTHGQT--
--INTARH------SQSGQG---------------QSTQTGSRVSRRRR-SSQSENIDSE
VHSRVSH----RHSEHIDTQVGSHYPESGST-----------------------------
------------------VHRRQGTTHGQR-----------------------GDTTRHS
HSGHGQSTQTGSRTTGRQRFSHSDATDSEVHSGVSHR---------PHSQEHTHGQDGSQ
LGESQSTV----------------------------------------------------
-----------------------HERHETTYGQTGD------------------------
------------------------------------------------------------
----ATGHGYSGHGQSTQIGSR--TSGRRGSGHSES-SDTEVHSGGSHRPHSQEQTHGQA
RSQHGESRS--TVHERHGTTHGQTGDTTRY----AHY---HNGQSAQRGSRTTG-RG-SG
HSEYSDSELYS-----------------------------------------GGSHTYSG
HTHGQAGSQHGESDSIVHERQQTTHGQTGDTTRHA---------------------HYGH
GQSTQRESRTAGKRGSGHSEYSDSEGHSGGSHTHS--GHTHGQAGSQHGESGSAVNRRQG
TIHGQT-------------------------------------------------GDTTR
HAQYG---------------HGQSTQTGSRTTGRRGS-----------------------
------------------------------------------------------------
-GHSEYSDSEGHSGGSHTHSG-----H-THGQAGSQHGESGSAVHGRQGTIQGQTADTTR
HGQS----GHGES-------------------------I-QTGSRTIGRRG-SGHSEYSD
SEGH-----------------------------SGVSLTHSGHTHGQARSQH------GE
SES------TVHERQQT-THGQTGDTTRHAHYGHGQSTQR--ESRTAG-KRGSGHSEYSD
SEGHSGVSLTH-------------------------------------------------
--------------------------SGHTHGQAGSQHGESESTVHERQQTTHGQTGDIT
EHGHSSHGQTTQTGSRT-----------------------------------------TG
RRGSGHSGYSDSEGHSGVSHTHSG---HT----------------HGQAG---------S
QHVESGSAVHGRQGTIHGQTGDTTRHGQSGHGES-------IQTSS--------------
-------------------------RTAGRRESGHSEYSDSEGH--SGGSHTHSGH----
-------------------------------THG-QAGSQHGES----GSTVHGRQGTIH
GQTGDTTRHGQSGHGQSIETG------SRTTGRRGSG-----HSEYSDSEGHS-GVSH--
---------------THSGH----------------------------------------
--THGQAGSQHGESG---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------SSGHGGQGTTHGQTGDTTRHAHYGHGQSTQRGS----------RTTGRRGS
GHSEYSDSEGHSGVSHTHS-----------------------------------------
----GHT---------------HGQ------------AGSQHGESGSAVHGRQGTIHGQT
GDTTRHGQSGH---------------GQSTQIGSRTTGRRGSGHSEYSDSEGHSGGSHTN
S-----------------------------------------------------------
-------------------------------------------------GHTHGQAGSQH
GESGSAVHGRQGTIHGQTADTTRHGQSGHGESIQTG-----SRTIG--------------
------------------------------------------------------------
--------------RRGSGHSEYSDSEGHSG-VSHTHSGHTHGQAGS-------------
----------------------QHGESGSSGHGRQGTTHGQTGDTTRHAHYGHGQSTQRG
---S-------RTAGRRGSGYS------------E-------------------------
-----------------------------------------YSDSEGHSGV---------
-----------------SHT--HSGHTHGQAGSQHGESE----STVHERQQTTHGQTGDI
TEHGHSSHGQTTQTGSRTT--G---RRGSGHSEYSDSEWHSGGSHTHSGHTHGQAGFQH-
--GESGSAVHGRQG----TIHGQTGDT----TRHGQSGHGESIQTGSR-TIGRRGSGHSE
YSDSEG------HSGISHTHSG--HT---------------------HG-QAGSQHGESG
-------SS-GHGRQGTAHGQTGDTTRH-------AHYDH---G-----------QSTQR
GSRTAGRRGSGHS----------EYSDSEGHSGVSHTHSG--HTH---------------
------------------------------------------------------------
-----GQAG---------------------------------------------------
SQHGESG--AAVHGRQGIIHGQTGDTTRHGQSGQG--------QS-----T--------Q
RGSR--------------------------------------------------------
----------------T-------------TGRRGSGHSEYSDSVGHSGV----------
---------------------------SHTHSG-----------HTHGLAGSQHG-----
---------------------------ESGSSG------------H--------------
--------GRQGTLHGQTGDTTRHGQSGHGESIQTGSRTIGRRGSGHSEYS---------
------DSEGHSGVSHTHS--------GHTHGQAGSQHGK-----SGSAVHERQGTIHG-
QTGDT--------------------------TRHAHYGHGQS---------------TQR
GSRTA--------GRRGSGHSEY-----SDS----EWHSGGSHTHSGHTHGQAG--SQHG
ESGSAVHGRQ-G---TIHGQTGDT-TRHGQSGHGQSTQIGS---------------RTTG
RRGSGHSEYSDSEGHSGISHTHSGHT----------------------------------
-----------------HGQAGSQHGES---------------GSSGHGRQGTTHGQTGD
TTRHAHYGHGQSTQRGSRTAGRRGSGHSEYS----DSEGHSGV----SHTHSGHTHGQAG
SQHGESES-TV-----------------------HERQQTTHGQTGDITEHGHSSHGQT-
---------------------------TQTGSRTIGRRG---------------------
---SGHSEYSDSEGHSGGSHTHSGHTHGQAGFQHGESGSAVH---GRQGT-IHGQ-----
--------TGDTTRH-------------------------GQS----SHGES--------
-------IQT---------------SSRTAGRRESGHSEYSD-----SEGHSVGSHT---
-HSGHTHGQA--------GSQHG------ESGSVIHGRLETTHGQTGDTTRHGHSGYGQS
TETGSRS-TR-----------------------------------------------TSH
--FQSRSSERQRHGSS--------------------------------------------
--------------------------------------HVWKHGSYG-----PAEYDYGH
TGY----------GPSGGRRK------SICNSHLS-----------WS------------
--------------ID--------------------------------------------
-----SATNEQ---------------------------------------------L---
SRH---------------------------------------------------------
------------------------------------------------------------
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-------------

----------------MSALLRSIFDITEIFNQYALHACD-GAALRKKELKELLEREFGD
VLRRPHD-----------PETVYLVLELLDRDRNGLIDFP-----------E-Y-L-T-L
-I---------------F-R-I-A-Q-A-C-Y--Y-A-L-S-Q-T-TG--L-E------E
E-KRV-K-H-E-G-K-G-SL-L--ND-RRQEKR-E-D-----------------------
-------------------------------RP-------------------------VE
G----------------RR---------QER--EL-VEK-ELQRERQQ-RREQRDR----
-------------QLRD-------------------------------------------
-----------------------EEQRLQRREQLEREEELREEKVQLQRRKGQKFDEFPE
EELQRR----ERQEQR--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------ERL--------RREEEL---------------------QQRRERLQ
RQ----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------EQEEQLQTRERQ--EL
KRER--------------------------------------------------------
---RE--------E--ER--Q-QRW------D-RQAQ---------------RERQEEEE
QLQRP-RQEEEG------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------R-----------------------------------------
---CELSE-----------------LRRE-RREEEQQLQR-RGREEPRER----------
--------------------------------------REES-QQERR----EQRL----
-----------------------TGE---------------QA-----QE---LGEGRWQ
WELRRE-------------------------------ADARQSK---VYSR---------
PGR-QEEQ-----RRRREQEEERR------------------------------------
-------------------RRLE---Y----------E------QELRWE----------
----------REDDAQRQREEEEQRR--DFQKQLEE-----ERERRRQRLS---------
-----A-RPLLTEQEERRVRAKES----------QEREQRLREEEEQRR------QRRE-
REQERKFLEEEQQIERSGRKGKFQEEDILQEDVERRRRQEDQSQDRNRRRQ--LEEES--
-Q---------RRRHQLYS-------KS------AKEVQAR-------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------EEEQL---KREEEQL---QREE------------------
------------------------------------QEKRLRQVRERQYREEKQLR----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------QELEEAQESRQLRDRQFREEEQRLDQ-ELEELQ
RRQQRERRFREEEQLRQE-----------------------REEEQLLRQQSDRKFQEDE
QLR---------------------------------RQEREQQLRQERDRKFREEE----
-----------------------------------REDEQLRRQE-----REQQ------
----------LRQERDRRFREVEEVRQERESEQL--R---------------QERDRRFR
EVEEVRQEREDEQLRLQERDRRFREVEEVRQEREDEQLLRQERDRKFRE----------E
DEQLRQERDRRFREVEELSQEREDESLGTQQQL---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------RQERDRQFLQD
------------------------------------------------------EQPLHR
QESEQQLRQERDRRLLEVEELHREREDEQLRRQQRDRKFRELEEL---------------
------------------------------------------------------------
----------------------RRQQRDRKFREVEELRQ---------------------
------------------------------------------------------------
---ELEDEQLRRQQRDRKFREVEELRQEQ--EDEQLRRQQRDRKFREVEELRQ-------
EQEDEQL-----------------------------------------------------
-----------------RRQQR------DRKFREVEELRQEQE-----------------
-----------------DEQLRRQQRDR-KFREVEELRQEQED-------EQLRRQER-D
RRFREGDELGLERANE--QLRRQELVGAFSQDQRNR-S----EQE-EEQRRRRQRSKFLE
EEQRLQLEAEEEKQRRWEQDRKFLLEKEQLRREEREEQRRRQE-----RDRQYREEE---
-----------QFAKDKRR-RQEQELLQEEEQRRRQEQERKLREED--------------
----------------------------------------------QGKRQFVNPPV---
-------------------RSSPLYEYIQEQRSQYRP-----------------------
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-------------

----------------MSRLLRGVFCVVEIFHTYAIEDGDNKATLTRTELRQLLEGEIGD
FLQPHV------------FHAVERKLNLLNFDRDGTISFE-----------E-FVL-A--
-I---------------F-S-L-L-N-P-S-YFD----I-S-----LLN---S-ELRL--
-MSKS-EK--IDA------VDLGAIG---GN---------IQQVVG---VGPT-------
-----------QERL----------------IFPS----------------------EMA
SSGQPSNEEG----------------EVGDEPMVS-PCEDIKTHSLPRNVSEPNDP----
---ENQQS-------------------------------------------------KED
---------AQEVAQNVPATEYDGVQ-FKRNT---AVEVPKQSTSPTQ--------EIPR
ERS-KP----SRRLSDT------KISDHM-------------------------------
-----------------------------------------------------IQRPTE-
-----------------DE------------------EHT-----------STTQDPFL-
------Q------------------KREKAT-------------GSKNT---DLS-----
VVAATGKSSQTQ---EIFEPMDD--TKL----SEAQETGKDAG------------RIPPE
-------------TN--LEEPKADAK---------------------VAESHGLPAQE--
------------------------------------------------------------
------------------------------------------------------------
------------------REHNTRDQSVQSRSRNV----SEISSRG--------K-----
------QEGEW-KE--------------------HER---------------------IT
LSPTA-------------DAETQDEKC--QEFPGSW-------RENDAKKDSAA------
-----------------------------------------KDPSSEEGNQN-----LPE
I--------------K-------ED----S-VSGKEARHSEEDTVYAFEINKNSPAAEET
LETRE----------RSQE-----------------------------------------
--------------------------------------------LASLEK-QSQRKKHRA
TRIQDK--PVRKEDHNE-----------------------------------GEDSELSL
TQSDEGFCEIPNSLAPEVGKSSSEIA---------------E------------------
--------PHVPEDSQ------------------SQIDHHGDAK---------QESHTNN
PDP---------------------------------------------------------
------------------------------------------------------------
---------------------------------------------QKQGAPGESSREQEA
V------VLSIQ------------------------------------------------
--EDGQLPEGQEQSARDGLHDG--------LSSR-----TKGGPGAAVEPSEGEEVQ---
---ETTAGS--ENRKALEAESLEAQ-----------------------------------
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-------------

----------------MSRLLRGVFCVIETFHKYASEDADHKAKLTGRELRQLLEGEIRN
FLQPHV------------FHAVERKLNLLDIDRDGAISFE-----------E-FLL-E--
-I---------------F-S-L-L-N-L-F-YFD----M-S-----SLN---T-EPRP--
-MSES-EK--MDD------ADLLATT---RR---------SQQVAG---VGPT-------
-----------QERL----------------VFAS-------------------------
-SAQPSHEEG----------------QAGEHSKTS-PQEDVKTHNLPRKVSESSDP----
---ENQHP-------------------------------------------------EED
---------GQEVAQDVPATEYDGVQ-FKRNM---PGEVSKQSSNPTQ--------AIPK
EGD-KS----IRRQCDT------TLSDHM-------------------------------
-----------------------------------------------------AQRPSG-
-----------------DE------------------EHA-----------STTQDPFP-
------Q------------------KEDR-A-------------VSEHT---DLS-----
IQVAAGKPSHTQ---KVIELMDD--TRI----SETQEPEKDAV------------RTPPE
------------TTN--LEDPKADR----------------------TSETHELPEQE--
------------------------------------------------------------
------------------------------------------------------------
------------------RKRETRNQSAQSGSRND----SETSSKG--------K-----
------REDGR-KG--------------------EER---------------------KT
GPPAP-------------EAQTQGEKC--EEFSGSR-------RGNGAGKGSGT------
-----------------------------------------QGLSSEEGNQN-----LPE
I--------------K-------EE----P-ISGKEARHSEGDTEDTFLTNKNSPAAEET
LGTRE----------ISQE-----------------------------------------
--------------------------------------------LAPLEK-QSQGKNPRA
TRTPDK--PVRKQDHSE-----------------------------------GEDPELAV
TQSGEGSCETPNSLAPEVGNSSSDSG---------------E------------------
--------LQMPGDLQ------------------SQEDTRGDAK---------PGSGNNN
PDP---------------------------------------------------------
------------------------------------------------------------
---------------------------------------------QKQGAPGESSRVQEA
V------VVSIQ------------------------------------------------
--EDRQLPEEQEQPAREK----------------------QHGPGAAVEPTEGGEVQ---
---ESTAGG--ENRKSPEAESSGAQ-----------------------------------
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-------------

----------------MPQLLQSVICVMEAFQKYAKEEGD-CWTLNSGQLKRLLLGEIGE
F-LKPFD-----------ILTAGTSLHFLDRDGDGSISFD-----------E-FIL-L--
-I---------------F-D-L-L-N-I-C-YQD----IHS---F-LNQ-EPKPKSNTEE
KFSGDTEACEAS-------EDYQKVAGPDQYEQ---RLT--GTE------SPS-------
-------LVNP-I--------E------------------------------------KV
PDTVSKEDPQDDL-ESPKLLGKEVEHNHPKSQY-----YGEEAKQSQ-------------
---E-----------------------RSQYVQATGADGIPPEEKKPPK-----------
E--FV----------------------KRTCS---QKDERIVSEEHEV----------PG
EQVDKDPRDHPSEQEKE-------------------------------------------
----------------------------------------QNVEIQ---SVHME---ETA
Q---RT----------------------SESPEGT-IIKD-------------VGEHTD-
-----TQGLAS-QEDHE--------RKLGTT---------------------DLP--AEK
AEEKLSE---TE---RLPEPRDDD--GT----SDIQEPLQIPS--EKQ------------
-E------QG-KEYETTKIP--AKGNG--------------------SRVP---------
---------------------ET-----EVFIDEKKEKRK------PE------------
-------TLDTVGKKDGEK---------TKQMETLTEQEAEG-----------KEK----
---QLE---GLE-----------EKGEI--------RKDSGIPDFKSVDDKN-HYEHKGP
AAP-E--------E--IKVSE-ISE------S-EYQ---------------------GD-
--------------------------------------KTPETRDRVQV--------SGS
QDDQSKGKN-RR----IIQILD---QPIEQYDRHQVENQDDGTLSETYSNPEDGKSGS-E
TR------DL---------------------PAQKKSQGQV--DA-----Q---------
-------------EQPDQG-----------------------------------------
-----------------------------------DCKNYLGTQESLVPGD--------K
SRTPEKEVLIDKDN-ENITEEQEKLAKEKKS----------------DTAEES-------
-------------------Q---SQP---------------ESQESMKQKATETSP---K
IEIKNPTD----------------D------------IDEQLSI---VPSA---------
E------------------KEDHR----KDPE-------AHGPEA-----EEG-------
-------------KGEESESQEA---P----------L-------EGQGPETQ-------
--------------GLALDA-----RPDTLNPIPRE-----DK--SAQKLAGEGSELQYA
VNKEDGSSPGLSELIKKKARD-----------T------KLCS-----------------
------------------------------------------------------------
---SSGDEI--QSNPIY----ENIQKTP------EQPDLLDTEEH----L-----DQTDT
----------SQ--TSSPELSVEREIQKSECS-DFPAL----LDPLYDDT--QEL-----
--RNQTGDPE--------------------------------------------------
-----------------------SDEEYGNQ-----------------------------
----------------------QEILAYQS------QEDIHGQPQ-----Q-EDQQQ--L
RDDSSRKY----------------------------------------------------
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-------------

----------------MPQLLGNIDGIIQAFSRYAKTEGD-CTTLTKGELKKLLEQELAD
VIVKPHD-----------PATVDQVFHLLDEDSKGTVDFK-----------E-FLV-L--
-V---------------F-K-V-A-Q-A-C-YKT----LNESS-QGACG---T-----QK
PGSQ-----HS-G----STQQRNDGDQRSHTEI--GRVEREQSHTR--------------
-------HG---------------------------------------------------
GEEQT-----------STGQNR--------SN--L-TTGTQTQG----------------
------------------------QDVTSTQICDQDR------------------WPKTQ
GQERG-TQQVRDKI----------EGQ----R------Q--------------P-----E
TGTT-----QTREQGRTHQTSETI-HTGT-------------------------------
--------------------------------------------TQTR--------EQDG
SHHQTRDRVT--------------------------------------------------
------------------------GGQSQIH-------------TGT-----TQTVEQDR
SRH---------------------------------------------------------
--Q---------------TRDRVTGG----------------------------------
-------QSQIHTGT-----TQT--------------REQGRTH--------------QT
SET--------------------------------------------------------V
TGGQSQIHTGTTQSTTQTREQD-------------------------GSHH---------
-------QTRD------RVTG-GQS-----------------------------------
QIHTGTTQTREQDRSH----------------HQ--------------------------
----------------TRDRVT---GG--QS----------QIHTGT-TQTV--------
-----------------------------------------E------------------
------------------------------------------------------------
----------------------QDRSHHQTRDRVTG------------------------
---------------------------------------------------GGGTQ----
TQTGCSQGWGQERSQQT-RE----------------------------------------
---------DMVEG------------------------HGHTQVGSTLPGGQDWSDSQRS
CSV----------TGGLQ-----------------------ENDYCQT------------
---QEPSFGGQEWSRHQTRET---VAQQQD--------HS--------------------
------------------RESEIHCQGSTQL----EGAG--QIQGGKRGLT-ARG-----
----------L--------------------------YSYFKGNKQ--------------
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-------------

----------------MPQLLNSILNVSKVFQDYAEYHGV-GASLSKKELKQLLLTEFGD
ILRRPND-----------PETVETILEHLDRDRNGYVDFH-----------E-YLL-L--
-V---------------F-Q-L-V-Q-A-C-HHK----LDS---K-FYG---S-------
RTSSQKEHDQE-G-----TRSHKFSES-TGR---QH----RQRYEGERR-----------
-NSHHN-QSEGQHQNVQH--DQ-SQRQDKDS-----------------------------
-----------------------------ERHDTD---PHCGQSETFHGDSHYGHSERQD
TDYSSDQSE------------SDNESSSSSQRLGY-------------KSSH--EQPKGQ
G--YV-------F-------------ALSQSK------NP------EQ-----------T
FHYGQS-----------------KTSGQQS------------SHGQ-SGRFR--------
--------KDSYSSQTS----------Q-----QESDSYEQY-GSQHQ-KSGNSQIERQG
QNSQYGQTNKKGHSSYHEQTE---------------------------------------
-----------------GQGQSFHYGQKGRQGQ------------SSHQ---GQ------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------KGR--QDQSSHQGQ-----KGRQDQSSHQ-G--QKGR
QDQSS-HQ-GQREGQD-QNSQWHRTD----------------------------------
-------------------RQG-------QSFHYGQTGGHSLSSHQGQTD---SQGQNSN
WHRTDSQGQSFH----YGQTGG--QGLSS-HQGQ----IDSQGQNSQWHRTDSQGQSFHF
DQAGREVQGS-----H---------------------NGQT--D---RQSQ---------
------------------------------------NSNWHRTDSQGQSFHFD-------
QAGREVQ---------GSHHGHTDRQSQNSNWHRTD------------------------
----------SQGQSFHFDQA-GREV-------------------------QG---SHQ-
GQT---DSQGQSSHWHQ-TD-----------------------------RQGQSS----Q
QGH--------KDR-QGQNTHQGQKGRQDLSSHQGQKGRQDQSPHQGQKGRQDQSPHRGQ
KGR-QDQSPHRGQKGRQDQSPHQGQKGR------------QDQSLHLGQ-----------
-------------KGRQDQSPHQGQKGRRDQS-----SHQGQREGQDQNSHWHRTDRQGQ
SFHY--GQTGGQGLSSHQGQIDSQGQNSQWHRTDSQGQSFHFDQAGREGQSS--------
----------HHGQTDRQSQSSHCGQSEIGKTENQGQNRHSLGTDR-TR-----------
--R-DSYVEQSGRSGKLSQQNSREEVR-QTQSQRSHDRREQQIQQQTWKP----KEDN--
-------------QHKLLAQV--QQ-EP--YSYEEYDWQSQSS-----------------
-------------------EQDH-------------------------------------
------------------------------------------------------------
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-------CG-------EEE-YQ-----------------DWDRHSVEDQENLYEMQNWQT
HEEEQSHQTSDRQTHVDEQNHQ--------------------------------------
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---------------------------------D--------------------------
---HHQQRERQTHEEKEKYQGGQDQ-----------------------------------
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-------------------------------SRSFPNREKSHMSED--------------
----------------------DQCEGP-----------------------------HGG
GKSQRREKSGNHPTKPA-NYSSPLYDYVQEQAAYQY------------------------
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-------------

----------------MSPLIRSIVDITEVFNQYASQSCD-GASLSKKDLKNLLERELGD
VLQRPQD-----------PETVDLTLELLDRDCNGRVDFN-----------E-F-L-L-F
-L---------------F-K-I-A-Q-A-C-Y--Y-A-L-D-Q-A--A--E-L------G
E-KRA-L-P-S-E-K-R-NL-S--QD-RRQ-ED-Q-R-----------------------
-------------------------------RF-------------------------EP
RSRQLDEEPG-----RRSWQKRRE----QEE--RA-EEQRLE----------QRHR----
-------------QHRD----------EEQ-R------------------LQRRELQELE
E--R------------------------------------LAEKEPLSWSKGRDAEEFSE
VEEQQR----QERQE-------LKGKGQTEER----------------------------
--------------------------------------RLQKR------RQEE-------
------------------------------------L--R-------------E--PLL-
-----R------------------------------------------------------
------------------------------------------------------------
--------------------------RDLELRREQEL-----------------------
-----------------------------------------RRE--------QELR----
---QEQRREQ---ELRREQ---------ELRQELRREQELNRRQELRREQELRREQ----
------------------------------------------------------------
---E--------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
LRQELRREQELRREQE----------------------LRQE------LRREQELRREQ-
------------------------------------------------------------
------------------------ELRQELR-----------------------------
-----------------RE------------------------QELRREQELRQELA---
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WQLENE-------------------------------ADARQNK---VYSR---------
PSR-QEQR-----LRQELEERQLR------------------------------------
------------------------------------------------------------
-------------------EQEEQRRDLQQQRPAEE-----ARQRN--------------
-------------QWERPQRAEER----------LEQEQRFRNREEQR------------
------FR--DEKLQRAELQDS------LLD--EEQRRLQEERREPNRSRQ--LREES--
-----------QRRHTLYA-------KP------SQRQRREEELR-EERL-----LQEE-
--------------------QRQQR--ERKYRR---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------EEDLQQEE------------------------------------
-------------------------KRLQQDEEQ--------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------LQRERRRLQRERQYQEEDLQQEEER
LQQ-------------------------------EEERLQ---RE------RRRLQQERQ
Y------------------------------------QEEDLQRLRDEDQRRDLKW----
QWQPRKENEVRSNRLFTKRRGDEEPIQHLED-SQER--ERRQDRRPLQDEEE-----EKR
ELEQERRRRQQRDRQILEEEQ----FQREH---QREARRRDETFQEEEQLQGE-SR---R
RQQERGGKFLEEERQLRTERE-----------------------EKRRRQEQEREFQEE-
EEH---------------------------------LQEREKELRQECDRKSREQ-ERRQ
QRE------------------EEQLRRQERDQRFRREQERHLERE-----EEQLRDRPSR
REQERHQEREEEQLRDRPSRREQERRLEREEEQLR--------------------DRSFR
REQELRRDR----KFREEEERRE-------------------------------------
---E--L-E----------------------------------EE-----QRG-QERDRL
RV--------E-EQL-R----------------------GQR-E----EEQRRRQECDR-
------------------------------------------------------------
-----KLHRE--------------------------------------------------
-----------------------QEIRQ-----ELEEERLRDRKLRREQELRRDRKFHEE
EERRHEEFE-----EKQLRLQESDRRFRREQELRQECVEE--E--RLRDSKIRREQELR-
--REREEERLRDRKIRRDQELRQGLEEEQLRRQERDRKFREEQELDQEPEEER-----LR
DRKIRREQELRLEQ-------------------------------ELR-----REREEER
LRDRKIRRDQ-ELRQGLEEEQLRRQERDRKVREEQELDQELEEERLRDRKIRR---EQEL
RREQELR-------------------------LEQ------------------------E
LRRER----EEERLRDRKIRRDQELRQGL--EEEQLRRQERD------------------
-------------RKFREEQELGQELEEERLRDRKIRREQELRRE------REQEQRRRL
EREEEQ----------RRRQERE-QEQQRCLEREEEKFR--FEEQQRRRQEREQQLRQER
DRRVLEEEELRQEREE---LLHRQVGG-RKFREEERLRLEREE-------QQRRLQERDN
RRFREEVELRQEREGQQLRQ---ERDRKFREVEELRQ-----------------------
---------EE-QRRRQERDRKFREEKHPR--EEREEQQL----RREKRDGQYLAEE---
-----------QFARDTIRRQ-EQELRQEEEQRRRQERERKFQEEQ-IRR----------
-----------------------------RQEEQRRRQILE-----PGTRQFANVPV---
-------------------RSSPLYEYIQEQRSQYRP-----------------------
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-------------

----------------MTDLLRSVVTVIDVFYKYTKQDGE-CGTLSKDELKELLEKEFRP
ILKNPDD-----------PDTVDVIMHMLDRDHDRRLDFT-----------E-FLL-M--
-V---------------F-K-L-A-M-A-C-NKV----LSK---E-YCK---A-------
SGSKKHRHGHR----------HQKEESETEEE--------EE-------DTPG-----QK
SGYRHSRWSEG-EEHGYG---SEVLRGARKHRHGS-----------------------D-
-SRRLGRQG------------------------GLSSSGNQEQFE-KRHHWSSS------
---------------------------GHSCS--------S--GKERHGSSS-EELGERR
N--------------------------KSHV-------------SPSR----ES-----E
KEYESG-------------------SR---------------------------------
--------------------------------------------LKSRRRKGHSALSHGL
DAS--GH-----E-SNST---------QSRQSGGQKLGSS-----SRSLGDNGRQNYVCG
SS---------------------------------------------------------N
SCGCG------------------RFGGQGNLSNCT-QSGCQSGSSGGLG-------QCSG
YGQ-----YESSSCS-QSSSQEEYGS----------------------RACGQ--TQNC-
GRQQRTG--SSQSSCCEQY-----------------------------------------
-----------------------------------------------G-------S----
-GTSQPATYGQH-----------GPGSC-GHFSNSHQKESGSSEFS--------------
---KC--------R--QHGS----------------------------------------
------------------------------------------GS----G-----------
---QSSG---------FGQHRS---G-----------------SGQS-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------SNFG--------------YG-----------SGSCQTSGFGQHES---------
G-----------------------------------------------------------
-------------SRQSSCFGQH---G----------S------SSG-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------QASGFSQH----------------------------------------
------------------------------------------------------------
----------------------------RSGS----GKS----------S---------G
YEQYE-SSS-GQ--SSSFG-KQE-SGSGQS---SGLGQHGSSS--GQSS-----------
--------------------------------G-V-------------------------
------------------------------------------------------------
-------G--------------------------KH-GSG--------SE-QSSG-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------VK-QTSGF--GEHRT------
-------GSG------------QSFGSGQHGSGSHQSTSTK-HRY-GSG-QSS-SF---G
YG-SS-KH-QS-PAS-----GT--------------------------------------
------------------------------------------------------------
--------------GSGQSTYGQHGSNSRKSYSSD-SRSSTGKS-STHSQHG--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------S----NSRQ----S------------------------------
----------------------------SRRE----------------GKTQ-------G
Q------SGDR-STQG-HS-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---GH-A-----------QA-TRTESSKTKRSDS-RVSKTS-DTERHS-GVPQ-THKG-T
PHSHSGSQHAE-SG--S---TAR-GR-------------Q-G---LS---GDTKGYS-GS
--GHG---QATRKESNKT------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------ARRGSSVS------------ESSDT--ERH--
--SGASQT------HAAGHG---------------QATRTESSKTARRG-SSVSESSDTE
RHSVAPQ----SHAG---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------SPHSLS
GSQHGESGS--TAGGRLGTSHG--------------------------------------
------------------------------------------------------------
--------------------------QSGYTRGHI---------------------GTQH
GQAISSKSGRSPRSGSNVSESSDNERHSR------------GSSRNS-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-------------

----------------MSQLLNSVLNVIKVFDKYAKEDEN-CASLCKEELRQLLLTEFGD
ILRRPND-----------PETVENILNLLDRDRDGYVDFH-----------E-YLL-L--
-V---------------F-Q-L-V-Q-A-C-HRK----LDS---K-SCG---D-------
RTSQ-QERRQE-R-----EKDHKFPGN-IGR---QH----RQRHEEEQQ-----------
-NSHHSQ----QGQD---------------SH--------------------------YG
QPERQDRDS--HY-GQTEKQDQDYHYGQS---------------EKQDRDSHHDQSERQD
KYHSFDQSERQ------------DQDSSSSKRLNH-------------KSGS--GQPKSQ
G--YV-------F-------------ALNECE------KP------AQ-----------G
SHCGQ-------------------------------------------------------
---------------PE---------------------------RLGQ-Q----------
------------------------------------------------------------
----------------------S-----RY----SC----YSQTSGSYY---GQSGRLGQ
ESGCSQRDRQE---LVSHYDQTDRQG----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------HSSHYGKTDR---------
------QGHNSH----YGQTSR--QGLSSQ-----YGQTDRQGQSSHYGQTDRQGQISH-
------------------------------------------------------------
------------------------------------------------------------
-------------------HGQADRQGLGSQYGQTDR-----------------------
-----------Q------------------------------------------------
---------G--------------------------------------------------
-----------------------------QRYHYGQTNRQGQSSHYDQTERQGQSSYYGQ
TDR-QGQNS------------YYGKTDR--------------------------------
----------------QSQS-----------------SHYGQIDRQGLCSHYGQTDRQGQ
SSHY--DQKDRQGQISHYGLTDRQGQGFHCGQTDRQGQNYHYGQTYGQDQNF--------
----------YYGQSQT---------G---ETETQRQNKYFQGTKG-RR-----------
--RRDENVEQSGRSGRLSQQTPGEEVY-QSQGQGFQTRDVQQNSPQVWEP----EKYSQ-
-----------RHQHKLLAQI--QQERP--LCNKERDWQSCNS-----------------
-------------------EQDHRQAQTRQHHDE--------------------------
------------------------------------------------------------
--------------------------E---------------------------------
------------------------------------------------------------
----QSHWA------EELQGHQ-----------------SWSRQSHEGQESPYEAQDRQT
HEEEQNHQRRDRQTHTEEQNHQ--------------------------------------
--RRDRQTHEEEQNH-Q-------------------------RRDRQTHEEEQNHQR---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-------------

----------------MTELLNSILTVIKVFQRYAKENGD-STSLCKEELKQLLLAEFGN
ILRRPND-----------PETVETILSLLDRNRNEHVDFH-----------E-YLL-M--
-V---------------F-Q-L-A-Q-A-C-YHR----LDN---E-SYG---D-------
RTSQ-QERKQE-G-----TQGHTFPRN-TGR---QH----KRRHEGERQ-----------
-DSCHS-QSEKQSQDTHQ--DQ-SERPDRDSL--------------------------YG
QSEGQDRDS--HY-GQTQRPDRDSHYGQTQRPDRD---SRYGQTQRPDRDSHYGQTQRPD
RDSHYGQTQRP------------DRDSHYGQTEGQGQDSRSG-QRLSNKSGS--GNPERQ
G--YV-------F-------------ALNQYE------KQ------LQ-----------D
SHYGQ-------------------------------------------------------
---------------PD---------------------------RLGQ-Q----------
------------------------------------------------------------
----------------------SSYGQSGRLREDPQYSHTNQQESGSYN---EQSGRLGQ
ESGCGQRNRQE---LDSHYGQTDRQG-L--S------A-----------HYSQTRP----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------ERQGQSYHYDQTDR---------
------QGQSSQ----SGQTDR--QGLNSH-----YGHMDRQGLSSHYDQTDRQGLSSH-
------------------------------------------------------------
------------------------------------------------------------
-------------------YGQMDRQGLSSHYGQ--------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------TDR--------------------------------
----------------QGLS-----------------SHYGQTDRQVLSSHYGQTDRQGL
SSHY--GQTDRQGLSSHYGQTDRQGLGSHYGQTDRQGQISHYGETDRQGLST--------
----------RYSQTDKQGVNSQHGQS---ETGETRQNRCFQGSEG-TS-----------
--R-DSHAEQSGRPGRPSQQTQGQEVN-QNQGQRPQTREEQQNSRQAWES----EEDT--
-------------QHKLVAQI--QQERP--PCHKGRDWQSHSS-----------------
-------------------EQGHRQAQTRQSHGE--------------------------
------------------------------------------------------------
--------------------------K---------------------------------
------------------------------------------------------------
----QSHQA------EEEQDHQ-----------------SCGRHSHEGQETPCETWDRET
CEDEQTRQRRDRQTHEDEQTGQ--------------------------------------
--RRDRQTHEDEQTR-Q-------------------------RRDRQTHEDEQTGQRRDR
QTREDQ-------QTC--------------------------------------------
------------QRRDRQTHEDEQTHQRR-----------D-------------------
--------------------------------RQTHEDEQTHQRQDRQTREDQQAGQSQD
RQTHEDKQIHQR----------------QDRQTHEDEQTGQRRDRQTREDPQTHQRRDRQ
THEDE-------------------------------------------------------
Q-----------------------------------------------------------
-------TRQRQDRQTREDEQTCQQRDRQTHEDEQAHQRRDRQTREDEQTHQQ-------
----RDRQTHEDE---------------------------------QTRQRQDRQIREDQ
QTRQRR----------------------------DRQTHEDEQAHQRRDRQT--------
--------------------REDQQTGQRRDRPTREDQQTDQ------------------
-------------RQDRQTHEDEQTHQRR--------------------------DRQTH
E----------DQQTHQRRDRQTHEEDQN-------------------------------
---CRRQQDQQTHKDKERYQESQYQQSQGT------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------QQGYANREKFHMNED--------------
----------------------GQSPSS-----QGRRSDLAFH------------PTQNA
GRPQRREQGGSHPIKAT-IAPNPLYDYVQEQKGVRH------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-------------

----------------MPKLLQGIVTVIEVFYQHATEDGD-CDMLSKKEMKELLEKEFHQ
ILKNPDD-----------PDTVDIIMQSLDRDHNNKVDFT-----------E-YLL-M--
-I---------------V-K-L-I-Q-A-C-NKI----IGK---D-YCQ---A-------
SGSKQKNHSHQ----------HQKEHNEEEKD--------D----------KE-----QN
ASSSYSSSSAG-ENDTYS---RGS-RR---------------------------------
------------------------------------------------------------
----------------------------------------S--NKNESKSSS-GKL----
----------------------------------------------------RK------
---GNQ-------------------QSSEE------------------------------
----------------------------------------ETR-SNSSHLKNNEKHEQH-
---HYGS----GSTTTSR-----------KSRR------S--------------STWEA-
---------SENQQTTKRSGQTPRSSRQGSGK----------------------------
-------------------------------------------------------HQTSG
-------------TG-KYDVS-----S--------------------EESSG--------
C-----G--TGHYTS-----------------------------TGE-------------
--------HGSA------------------------------------------------
--SGQSTSYGKH-----------NEQS--------------------------------S
QSSSQ--------K--RNDSGPGK------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------SFGSSEYG-----------STSGQSYGSRTK-Q---------
F---GKGQS-----------D---------------------------------------
------------------------------------------------------------
------------------------DTFLV----------------HFKSV----------
---SEQE-----------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-------------

----------------MAQLLNSILSVIDVFHKYAKGNGD-CALLCKEELKQLLLAEFGD
ILQRPND-----------PETVETILNLLDQDRDGHIDFH-----------E-YLL-L--
-V---------------F-Q-L-V-Q-A-C-YHK----LDN---K-SHG---G-------
RTSQ-QERGQE-G-----AQDCKFPGN-TGR---QH----RQRHEEERQ-----------
-NSHHS-QPERQDGD---------------SH--------------------------HG
QPERQDRDS--HH-GQSEKQDRDSHHSQP---------------ERQDRDSHHNQSERQD
KDFSFDQSERQ------------SQDSS--------SGKK---VSHK--STS--GQAKWQ
G--HI-------F-------------ALNRCE------KP------IQ-----------D
SHYGQ-------------------------------------------------------
---------------SE---------------------------RHTQ-Q----------
------------------------------------------------------------
----------------------S-----ETLGQASHFNQTNQQKSGSYC---GQSERLGQ
ELGCGQTDRQG---QSSHYGQTDRQD-Q--S------Y-----------HYGQTDRQGQS
-------------------S--HYS-------------------------------QT--
---DR----QGQSSHYSQPDRQG-------------------------------------
------------------------------------------------------------
-----------------------------------------------QSSH---------
------YGQMDRKG---QCYHYDQTNRQGQGSHY-SQPNRQGQSSHYGQ---P---D-T-
---------------------------------------QDQSSHYGQTDR---------
------QDQSSH----YGQTER--QGQSSH-----YSQMDRQGQGSHYGQTDRQGQSSH-
------------------------------------------------------------
------------------------------------------------------------
-------------------YGQPDRQGQNSHYGQTDR-----------------------
-----------Q------------------------------------------------
---------G--------------------------------------------------
-----------------------------QSSHYGQTDRQGQSSHYSQPDKQGQSSHYGK
IDR-QDQSY------------HYGQPDG--------------------------------
----------------QGQS-----------------SHYGQTDRQGQSFHYGQPDRQGQ
SSHY--SQMDRQGQSSHYGQTDRQGQSSHYGQTDRQGQSYHYGQTDRQGQSS--------
----------HYIQSQT---------G---EI--QGQNKYFQGTEG-TR-----------
--K-ASYVEQSGRSGRLSQQTPGQEGY-QNQGQGFQSRDSQQNGHQVWEP----EEDSQ-
-----------HHQHKLLAQI--QQERP--LCHKGRDWQSCSS-----------------
-------------------EQGHRQAQTRQSHGE--------------------------
------------------------------------------------------------
--------------------------G---------------------------------
------------------------------------------------------------
----LSHWA------EEEQGHQ-----------------TWDRHSHESQEGPCGTQDRRT
HKDEQNHQRRDRQTHEHEQSHQ--------------------------------------
--RRDRQTHEDKQNR-Q-------------------------RRDRQTHEDEQNHQR---
------------------------------------------------------------
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-------------

----------------MSTLLENIIAIINLFHDYSTTDKE-TDTLSRKELKELLEMEFRP
ILKNPDD-----------PDTADIFMHILDLDHDKKIDFS-----------E-FFL-M--
-V---------------F-K-L-A-Q-A-Y-YDM----TRG---Q-NFQ---A-------
SEQNQKKYAYH----------TQDEENDIREDE-VEEEK-EE---GIRK-----------
-----SSQS-G----------KSH-RKGKKT---------------------------IA
NNPK-GRQGKGHE-QTLDS-SRHA----RSHKGETADNGHSESGS-PHHQSSNQ------
---------------------------AHRSRQSHSEHGKS--SS-----EI-RPVK--N
P--------------------------GSRI--------------SQDSDNEGQ-----S
EDLERQ-------------------FGSGSGN-------------------------QQG
SAHG------------H------------------GGDSSRNSESHQWQRGNHRQPKST-
-----------------------------HRRSG---------------------SHT--
------------------------RRRQGSTHGHSTHTSK----------------KSRS
P----------------------------------------DEDTSSQGHCNSFHRKSKP
-----------RTTG-RQESQ-----H--------------------E--------QSA-
DISK------NSGIEYGQYS---------------S-RSKASRYQESSLSQDSDT----E
GHSEDLGRESSMTHKRTE-------------STLKNKHWSNHSRS-PD-------R----
-SRQTGSHQGQR-----------NIHME-PNSIHQ---DSGPTTRER-------QGCH-P
EQSQD--------S--SRHWETGHG------Q-ISSG-----------------------
---------------------------------------SDNTRH---------------
-------QG-SS----ISQASD---SE---------------GQSEDSDIQ---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------SGSVQ--E
WS---------------RSSQEGKYG-----------SVHGSPDHSGYYFY---------
PIPSQEHFD-----------S------------------AHGQ-P---------------
-------------RP---------------------------------------------
------------------------------------------------------------
------STRGRQGSRHEQARDSSRH-A-----G---------SHEGQAADGE--------
------------------------------HSQSGS----RHQQPSTWTHGSRQSQSGHG
QSSSEF-------------------RSQKHRES--SFSQDSDSEGHTEDSQSQFGYGSET
R---------------------HGHVQDSSRRSESHQG--------QRNN----------
---HG--------QS-----------ESG-----H-----G-------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------HSDTG---------SRRQGSSYG-----------------
-------HSNDTSRQSGS-H-------G--------------------------------
------------------------------------------------------------
----------------------------GEPSSRGHS-----------------------
-------D------SYHGQSTSRK-RGRP-ESQREQSVDRSRHSGTEHGQLYSGS-----
----------SGSRHQGPSMSLASS-------------------SEGHS---EDSGTEFA
MTH--ENSXXXXX------XXXXX------------------------------------
--------------------------X--XXXXX-XXXXXX-------------------
---------------X--------------------------------------------
------------------------------------------------------------
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-------------

----------------MPQLLRNINGIIEAFRRYARTEGN-CTALTRGELKRLLEQEFAD
VIVKPHD-----------PATVDEVLRLLDEDHTGTVEFK-----------E-FLV-L--
-V---------------F-K-V-A-Q-A-C-FKT----LSESP-EGACS---S-----QE
SGSL-----HP-G----ASRELGE-GQRSGTEV--GRAGKGQRCER--------------
-------SS-------------------------------------------------QG
QSEQV-----------SRGQNG---------------PGAQTQG----------------
------------------------QATGSVWVSSHDR------------------QAESQ
SQERT-SPQTQLWGYTEQTQAVGEGQSRQTRE------M--------------R-----P
Q---------TRERDRAHQTG-----RSG-------------------------------
--------------------------------------------TQTQA--GATQTLDQD
SSHQTGGTSTQTQESTNGQNRET----------------E--------------------
-----THGQGRSQTSQ-----AVTGGHAQTQ-------------ARSHT-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---QTPTQTMEQDSSH----------------QTGGTSIQTQESTNGQNRETETHSQGRS
Q---------------TSQAVT---GG--HT----------QTQAGSHTQTP--------
-TQTVE----------------------------QDSRSQTS------------------
------------------------------------------------------------
----------------------QDRSQTVSHGGARE------------------------
---------------------------------------------------QGQTQ----
TESGSGQRWSPASKPEA-GE----------------------------------------
---------TVLG-------------------------GQAQTGASTASGRQDWSSP---
-SV----------TEGRG-----------------------DRQPA--------------
-------VVREEWVDDHSRET---AILRPDHGS----PHT--------------------
------------------SVSSAQGRDAAQ------------PE-EKRGIT-TRE-----
----------L--------------------------YSYFRSNQP--------------
------------------------------------------------------------
------------------------------------------------------------
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-------------

----------------MSPLLRSICDITEIFNQYVSHDCD-GAALTKKDLKNLLEREFGA
VLRRPHD-----------PKTVDLILELLDLDSNGRVDFN-----------E-F-L-L-F
-I---------------F-K-V-A-Q-A-C-Y--Y-A-L-G-Q-A-TG--L-D------E
E-KRA-R-C-D-G-K-E-SL-L--QD-RRQEED-Q-R-----------------------
-------------------------------RF-------------------------EP
RDRQLEEEPG-----QRRRQKRQE----QER--EL-AEG-EEQSEKQE-RLEQRDR----
--------------QRR---------DEELWR------------------Q-RQEWQERE
E--R----------------RAEEEQ-LQSCK-------------------GHETEEFPD
EE-QLR----RRELL---------------------E---LRRKGREEKQQQRR------
-------------E------------------R--QDRVFQEEEEKEW-RKRETVLRKEE
---------------------------------EK-LQEE-------------E--PQR-
-----QRELQE-EEEQL--------RKLERQ---------------------ELRRERQE
E----EQ--QQQ---RLRREQQLRRKQE-EE-RREQQEERR-----EQ---QERREQQEE
RR--------------EQQL-----RREQEERREQQLRREQEEE---RREQQLRREQEE-
-ERREQQL------RREQQLRRE---------QQLRREQQLRRE--------QQLR----
R-EQQLRREQ---QLRREQ-QL-R--R---EQQLRREQEEER--HEQKHEQERREQ--RL
KRE-------QE-----------ERRDW--------LKREEETERHEQE----RRKQQLK
RDQEE--------E--RR----ERW------L-KLEEEERREQQE------RR-----EQ
QL-RR-EQE---------------------------------------------------
---------------------------------------ERREQ------RLKRQEEEER
LQQRLRSEQQLRREQE--------ERREQLLKREEEKRLEQE-RREQRLKREQEERRDQL
LKREE---------ERRQQ-RLKREQEERLEQRLKREEV----------ERLEQEERREQ
RLKREEPEEERRQQLLKSEEQ-EERRQQQLRR--EQQERR-EQR----------------
---------------------LKREEEEERL-E-QRL-KREH-EEERR----EQEL----
---------------A--EE---EQE---------------QA-----RERIKSRIPKWQ
WQLESE-------------------------------ADARQSK---VYSR---------
PRK-QEGQ-----RRRQEQEEKRR------------------------------------
-------------------RRES---E----------L---------QW---Q-------
----------EEERAHRQQQEEEQRRDFTWQWQAEE-----KSERGRQRLS---------
-----A-RPPLREQRERQLRAEER----------QQREQRFLPEEEEKEQRRR--QRRE-
REKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQ--LEEER--
-K---------RRRHTLYA-------KP------ALQEQLRKEQQ----L-----LQEE-
------E-EELQ--REE-REKRRRQEQERQYREE-EQL-QQEEEQLLREE----------
-REKRR-RQERERQYRKDKKL-QQKEEQLLG--------------EE-------------
---------PEKRRR-QEREKKYREEEELQQ-------------------------EEEQ
LLR---------EE-REKRRRQEWERQYRKKDELQQEEEQLLREERE---------KRRL
-QERERQYREEEELQQEEE--QLLGEERETRRRQELER-QYRKEEELQQEE-EQLLRE--
-EPEKRRRQ-----------------ER--------------------------------
----ERQCREEEELQQEEEQLL-------REEREK---RRRQELERQ-------------
------------------------------------------------------------
------------------YREEEEV---QQEEEQL---LREE------------------
------------------------------------PEKRRRQELERQYREEEELQ----
--Q-------------------------------EEEQLL---RE--EQEK-RRQERERQ
Y-----------------------------REEEELQRQKRKQRYRDEDQRSDLKW----
QWEPEKENAVRDNKVYCKGRENE-QFRQLED-SQLRDRQSQQDLQHLLGEQQ------ER
DREQERRRWQQRDRHFPEEEQ----LERE--EQKE-AKRRDRKSQEEKQLLRE-EREEKR
RRQETDRKFREEEQLLQE-----------------------REEQPLRRQERDRKFREEE
LR---------HQEQGRKFLEE---------EQRLRRQ----------------------
----------------------------ERERKFLKEEQQLRCQE-----REQQ------
----------LRQDRDRKFRE---------------------------------------
-EEQ--------QLSRQERDRKFREEE--------QQVRRQERERKFLE----------E
EQQLRQERHRKFREEEQLLQEREEQQLHRQ------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------ERDRKFLEE
EQQLRRQERDRKFREQELRSQEPERKFLEEEQ------------------QLHRQQRQRK
FLQEEQQL------R----RQERGQQRRQDRDRKFREEEQLR------------QERE--
---E-----QQ-------LSRQERDRKFRLEE-QKV--RRQEQERKFMEDEQQLRRQ---
--EGQQQLRQ---------ERDRKFREDEQLLQER--------EEQ-Q------------
------------------------LHRQERDRKFLE--------------------EEPQ
LRRQEREQQLRHDRD-RKFRE---------------------------EEQLLQ------
EGEEQQLRRQERDRKFREEEQ-------------------QLRRQERERK---------F
--LQEE--------QQLRRQEL------ERKFREEEQLRQETEQEQLRRQERYR------
--KILEEEQLRPEREE-Q-QLRRQERDR-KFREEEQLRQEREE-------QQLRSQES-D
RKFREEEQLRQEREEQ--QLRPQQRDGKYRWEEEQLQL----EEQ---------------
------------------------------------EQRLRQE-----RDRQYRAEE---
-----------QFATQEKSRREEQELWQEEEQKRRQERERKLREEH-IRRQQKEEQRHR-
-----Q----V------GEI--------KSQEGKGHGRLLE-----PGTHQFASVPV---
-------------------RSSPLYEYIQEQRSQYRP-----------------------
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-------------

----------------MAQLLNSILNVIKVFQKYAQENGD-CTLLCKKELKQLLLAEFGS
ILR RPND-----------PE TVETILSLLDKDRNGHVDFN-----------E-YLL-L--
-V---------------F-Q-L-V-Q-A-C-YRK----LDA---K-SCG---D-------
RTSQ-QEGEQE-G-----TQDQKFPRN-TGR---QH----RERHEGERQ-----------
-DSHCG-QSGTQDRD---------------FR--------------------------HS
QSRTQDRDS--HH-GQSGTQDRDSHHGQS---------------GTQDRDSHHGQSGTQD
RDSRCGQSEKR------------GQDSSSGQRLSH-------------KSVS--DQSKGQ
G--HI-------F-------------ALNQCE------RQ------VQ-----------D
SLYDQ-------------------------------------------------------
---------------SG---------------------------KGR-------------
------------------------------------------------------------
----------------------------------SRSSQRNQQESGSYY---GQSGRLGQ
ESGCDHRDSQEL---D--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------SQHGQTDR---------
------QGQSYH----YGQTDR--QGLSSQ-----YGQTDRQGLSSQYGQTDRQGQSYH-
------------------------------------------------------------
------------------------------------------------------------
-------------------YGQTDRQGPGS------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------QRSQPET---------G---DT---GLNRRFRESAD-T------------
--SRDPRAEWSGRPGPLSQQTQGQEAN-RDQGQRVQSRQGQQNSHQAWGP----EEDSQ-
-----------HHQHKLVAQI--QQERP--HCHRGTDQQSCSR-----------------
-------------------EQGHRQAQTRQSRGE--------------------------
------------------------------------------------------------
--------------------------G---------------------------------
------------------------------------------------------------
----QSHQA------DEEQGHQ-----------------SWGRHSLEGQETTCETWDRQT
HDDQQGHQRQDRQTHDDQQGHQ--------------------------------------
--RQDRQTHENQQSH-Q-------------------------RQDRQTHDDQQGHQRQ--
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-------------

----------------MSPLLRSIFDITEIFNQYASHYCD-GAALCKKDLKTLLEREFGA
VLQ RPHD-----------PE TVDLILELLDRDSNGLIDFK-----------E-F-L-L-F
-I---------------F-K-V-A-Q-A-C-Y--Y-A-L-A-Q-A-SG--L-E------E
G---A-R-R-E-G-E-G-SP-L--QD-RWQEEE-P-R-----------------------
-------------------------------RF-------------------------EP
RDRQLEEARR-----QKR----QE----RDR--EL-AQEE------------QR------
------------------------------------------------------------
---------------------------LAQCHGEKRRKRPRGGGEPLQRRQARAPERVPD
QERGRE----KRPLREP---APED------------A---QRQH-------QRQ------
-------------E-------------------------------------EEQLPRREQ
-----------------------------QELERE-RLEE-------------E--PQL-
-----QR--------------------RGRQ-----------------------------
---------------------------------------------------EPRSE----
------------------QE-----RREQRERR---------------------------
-------------------------------------EQQLRSE--------QEPR----
S-EQKLRREQ---ERRLE---------------------------QNRLEQERREQ--EL
RREQEPRS-----------------------------------------------EQKLR
REQ----------E--RR----------------LEQE---------------------S
---RL-EQE---------------------------------------------------
------------------------------------------------------------
-----------RREQE--------PRSEQKLRREQESRLEQESRLEQ-ERREQEP-----
--------------------------------------------------------RSEQ
KLRREQ----------------EPRLEQERRE---QRE--------RREQEA--------
----------RSEQKLRREQE------------------QRL-EQERR----EQQLA---
---------------EE-EA---QQE---------------EA-----RERGEGRIPRWQ
RQLERE-------------------------------ADARQSK---VYSR---------
PRR-QESQ-----RGLREREEEEE------------------------------------
-------------------EEEE---E----------E----------------------
--------------------------------------------R---------------
-------RRQEREQRDRQPRADER----------EERER----------------QDRE-
----------------EEEERQLQEEE-RLREDRERERRQELRRDQKWRWQ--LEEES--
-Q---------RRRHLLFA-------KP------AAREQRREEEQ----L-----RREE-
-----------------------------------EQL-RREEEQLRRE-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------ERRQQYLEEEEEE----
------------------------------------------------------------
-E----------------------------EEEKKVQRGDRKRPFADEDQRRDLKW----
QGRREKENEGRNDEVYTKRAETEEKIRQLED-SQVRERRFQQDPWPLQDEQE------EG
AREQERKSWRQRDRRFSDEAL----RERE--EQK-EDKRRDRKFPEEEQLLKE-ERGEKR
RLREEDSKFREEEQQLRRQE---------------------EEEQQLRRQERDRKYQEEE
QQL----------------------------------------RRQERDRQFQE------
--E------------------EQQLRRQERNRKFQEEEQQLRRQE-----REQQ------
----------LRQERNRKFQEEEQQL----------------------------------
--------------RRQERDRQFQEEE--------QQLRRQERNRKFQE----------E
EQQLRQERNRKFQEEEQQLRRQEREQQLRQ------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------ERNRKFQEE
EQQLRRQERDRKYQEEEQQL----------------------------------------
------RRQERDRQFQE--------EEQQLRRQERNRKFQEEEQQLRRQEREQ-QLRQER
DRKYQQEEQ---------QLRRQERDRQFQEEEQQV------------------------
----------------------RRQERDRQFQEEEQQLRRQEREQQLR------------
------------------------QERDRK------------------------------
--YQEEEQQLLRQERDRQFQEEEQQLRRQ--EREQQLRQARDRKYQEEEQ----------
-----QLRRQERDRQFQEEEQ---------------------------------------
---------------QLRRQER------DRKYQEE-------------------------
-----------------EQQVRRQERDR-QFQEEEQQLRRQER-------EQQLRQER-D
RKYQEEEQE----------LRRQERDRQFQEEPQE-------------------------
------------------RDAQLRGEEEQLQRGQLAELRRRQQ-----RDRRYPAEE---
-----------QFAQEKRRR-EGQDLRQE----------------E-----QEEAQ----
-----R----R------RQV--------WEESDKGGQQVPE-----PGKRQ-ARAPV---
-------------------RSSPLYEYIQEQRSQYRP-----------------------
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-------------

-----------------SKLLQSIITTIDVFYQYAIQKGE-CDMLNKTELKELLENEFHQ
ILKNPDD-----------PDTVDVIMQSLDRDHNKKVSFT-----------E-YLL-M--
-I---------------Y-R-L-A-H-A-C-NKI----IGK---D-YCQ---A-------
SGSKQRDHSHQ----------HQEEQNETEER--------E---------ENE-----QE
SSSRYSSSSAG-EKDSYS---RGS-RG---------------------------------
------------------------------------------------------------
----------------------------------------N--QKQTES-SS-RKL----
----------------------------------------------------RH------
---QRG-------------------LSSSG------------------------------
----------------------------------------HRQ-SS-------EERTDS-
---SLGH----FK--------------------------N--------------SEKNK-
---------HGSQQHES-------------------------------------------
------------------------------------------------------------
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-----------------------------GSGQNYL-NR-RH-EST-SSE-HSG-YG-KH
-RSH-SG-QS-STQ-RT-QE------SNSR-QT---TH---------GS-----------
---GS---------GR-S---------STF-EE-C-----GS------------------
-------------------GLG-QS-----------------------------------
------------------------TS-NGQ-------HSS-TS----------------G
-Q-SS--CYD-Q----H-G-SS-SGQ-SSGY---GQQ-GSG-L-----------------
-------GQ-SSSY-GH-------------------------------------------
-----------------------------H---SST-S--GQ------------------
-------------------------------SCCGQ------------------------
-------H----------------------------------------------------
------------------------------------------------------------
-----GS--SSG-------QSS-SY-GQH-GS----G-SS---------Q----SSS-YG
--QHG-SS-SRQ------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------S-S--S-----------H-R-QH-G
-Y-E----------S--GQS------------------------SGF--GQQAS------
-------RSR------------QSTGSSQHGSGLS------------Q------------
-----------------------------------------------------SSSYGQQ
-GSTT-R---------QSCCGQHGSSSGQSSNYGQQGSGFNQSS--------SYG-----
----------EH------------GCASGQFFQHRRHGSCSKRI-SGFSQHESSL-----
-GQSGSGSGQ--------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------SSQYSQHV-SGSS--------QSS-SHSQ---------
--------------------------------------------QGSGLGQSFRYGQHGS
GSGHSSSHS--------------QQGSISGQSSRYGRHRSGSSQSSSHSQQGSGLG----
------------------QSSRYSQHGSGSGHS---------SSHSQQGSGLGTSSRYGQ
HGSG--------------------------------------------------------
---------------------------SGHSSS-HSQQGSISGQSSRYGQHRSGSSQS--
--SSHSQQGS--------------------------------------------------
------------------------------------------------------------
----------GLGQ--SSRYGRHGSGSSQ-------------------------------
------------------------SSSHSQQGSISGQSSRYGRHRSGSSQSSSHSQQGSG
LG----------------------------------------------------------
----------------------------------------------QSSRYSQHGSGSGH
S-----SGFGQSSGL---------------------------------------------
-------------GKSSGHGQL--GSGS--------------------------------
-----------NQSSNHS------------------W-------Q---------------
------ESNHS------------------------------------------SGFSPQR
SGSGQS-SGYGQQGSGFS--QSSSYGQHGSTSGQS-SCCGQHESSSGETPSY--------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------NQH----------------
------------------------------------------------------------
----------------------------GSASGQFS-------NHSRHVSGSRESSGF--
-SQH----------------------------------------------ESGLGQSDRY
GQQG--------------------------------------FGSNQSSS----------
----------------------------H-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------SQQGSGLGQSSRYGQHGSGSG-------------HSSGFGQ-----
--------N-QSGLGQSS----------------GH------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---GQLG-----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------SGSNQSS
NH-------------SWQESQSQQSSG--FSP---------QRSGSGQSS----------
-----------------------GYRQHGS--------G-FSQSSSYGQHGSTTGQSCCG
-QHGSSSG-------------------------------------------------QSS
N-----------------------------YGQQGS-GFNQSSS----------------
----------YGEHGCASGQFS--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------SH--RRHGSGSRESSGFSQ------
--------------------------HESSLGQSGSGSGQSSQYGQHGSGSS--------
-----------------------------Q------------------------------
----SSSHSQQGSGLG--------------QSSRYGQHGSGSGHSSGFGQN---------
----------------------------------QSGLG---------------------
------------------------------------------------------------
--------QSS-------------GHGQLGSGS-----------------NQSSNHSWQE
SQSQQ-----------------SSGFSPQRSGSGQSSGFNQQ------------------
--GSGL-------GQS------SSY------GHHSST-----------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------SGQS-CCGQHGSSSGQSSSYGQHG--------
-------------------------------SG-------------SSQSSSYGQHGSSS
RQSS-------------SHRQHGYESGQSSGFGQQASRSRQSTGSSQHGS-GLSQSSSYG
QHGSTTGQSCCG-QHGSS---------------------SGQSSNYGQQGSGFNQSSNYG
EHGCASGQFSSH--RRHGSGSRESSGFSQ----------------------HESSLGQSG
SGSGQSSQYGQH------GSGSSQSSSHSQQGSGL--GQSSRYGQHGSGSGHS-SSHSQQ
GSISGQSSRYGRHRSGSSQS--SS-------------------HSQQGSISGQSSRYSQH
-------------GS---GSGHSSGFGQNQSGLGQSCGYGQLRSGS--------------
--------------------NQSSCHSRQESQSQHSSGFSPQRSGTG------QSSGYGQ
QASRSG--QSSHSNQQGSG----FGQSSSYG----------QPSYGGCSSGSGHSSCHNQ
QGTSSGQSTGYGQPGSFSGHYSSHSQHVSG----SGQCPNY--------------EQYGS
GPCS--------------------------SSSSEQHNYGYGQCSSSEQYVPCSY-PSSS
G-------------QYSS-------------------GSGQCYG--SEQCGSASCPSSSA
GQYGSGSYPSS-----------------------------------SGQY----------
----------------------------IS---------------GSSQCSSSQQY-MSG
K-EDGNRC-RHSNCSEGQRQGGYRYQ-RRGGSYC---------EGESRFVSSTPFYEYVQ
ELRTFGQ-----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-------------

----------------MPRLLRDVLCVIEIFHKYASEDSN-GATLTGRELKQLLQDEFGD
FFQPCV------------LHAVEKNSNLLNIDSNGIISFD-----------E-FVL-A--
-I---------------F-N-L-L-N-L-C-YLD----IQL-----LLS---S-ELRQ--
-VTKP-EKEKPDD------VYLQATT---RD---------GQWTAG---TSPT-------
-----------QEER----------------MLPS----------------------GMA
SLSQLIPEES----------------GAVGNNRVD-PWREAKTHNFPGEASEYNNP----
---KNQHL-------------------------------------------------EGN
-------EQIQEVAQDVQTTEDNEGQ-LKTNK---PMAGSKQTSSPTK-RKG-QDKKISW
EGD-EP----VREQSVS------KIRDQF---------------GEQEGNLE--------
--------------------------------------------TQNSPPEEATQRPSE-
-----------------DQ----------EVRTEK-E--K----------YSNTQEPPL-
------Q------------------GEDE-P-------------SSERA---DLP-----
EQAAARTLSQTQ---KSTDPKDV--CRT----FDTQEPGKDAD------------QTPAE
------------TKN--SGEPEDYGR---------------------TSETQE-------
------------------------------------------------------------
------------------------------------------------------------
------------------KESETKDLPVQGGSRNG----SETSDMK--------DERKER
RGPKTHETAGQ-KE--------------------RDR---------------------KT
RPLVL-------------ETQTQDGQH--QEFQGLS-------KSKDAEKGSET------
-----------------------------------------QYLSS-GGDQT-----HPE
L--------------E-------GT----A-VSGEEAEHTKEGTTEAFVNSKNAPAAART
LGARE----------STQD-----------------------------------------
--------------------------------------------LAPLEK-QSTVENSRV
TKTHDK--PVEEEDDYQ-----------------------------------GEDPESPF
TQNDEGSSETPSSLASEEDNSSSETG---------------E------------------
--------LPVQGDSK------------------SQGDPHGESV---------QGGHNNN
PDT---------------------------------------------------------
------------------------------------------------------------
---------------------------------------------QRQGTPGEKNRAQEA
V------VPAVR------------------------------------------------
-GEDVQLTEDQEQPSRGEHK-Y--------QGPG-----T-KGPGVAVEPSGHPEAQ---
---ESTAGD--ENRKSLEIEITGALDED--FTDQLSLMQLPGKGD---------------
-------------------SRNELKVQGPSSKEEKGRATEAQYTILKSLDEDSSASH---
--KIQLEKKK-------TVTS-EEEDESPQELAGEGGDQKSLAKKEEHNSSVPWPSLEKQ
MQTDQQPCSVERGAVHSSPLYQYLQEKTLQQTNITQE--------------------DHQ
K---------------------------------QVQIAQASGPE---------LCS---
-VSLTSETSDFSVFFNYNQASQ---------------SYTRGLPLDECPAGA---PAPQA
LEDKQGHPQRERLVPQREASTT----------------------------------K---
-----------------------------Q------------------------------
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-------------

----------------MPRLLRDVLCIIKTFHKYAQEDGN-KATLTCTELKQLIQGEFGD
ILQPYA------------IHAVEKNLNLLNIDK-STISFD-----------E-FVL-A--
-I---------------F-N-L-L-N-L-C-YLD----IQS-----LLK---S-EPRQ--
-VSKP-EE-KPDD------LDLQVTS---ST---------GQQTEQ---TPPT-------
-----------QDRV----------------VPPS----------------------GMT
SSAQLSFVGR----------------GAVGYNGA----KNTKTYNLPVEASGRNDP----
---ENQHP-------------------------------------------------EGD
-------QWSQDVAQDVSATRDNGVQ-LETNK---LTADSEQTDSPTK-QER-QEKESPR
ERD-KP----VREQSDT------KKSDRF---------------GEHEGNLR--------
--------------------------------------------LQSSPPGKTTKRPSK-
-----------------DQ----------KVATEK-DVKE----------HSKTQELSL-
------T------------------GKYE-P-------------SSEHT---NLP-----
EQATAQKPLQTE---KLTDPDDD--GST----FETQGQGEDAD------------RTPPE
------------TKN--LAESGDDSR---------------------ASETQEPPAQE--
------------------------------------------------------------
------------------------------------------------------------
------------------KKHETKDLLVQGDIRNV----SEIPDAQ--------VIRKKR
RSPMAHGTAGQ-KE--------------------NER---------------------KI
QLSTL-------------EDQSQDGKY--QELQESS-------KERDAVEDSKT------
-----------------------------------------QVSSS-EGEQN-----HSE
I--------------E-------RA----V-TPGEEARHAEEGIAEARMSSKNAPAAEET
PGARE----------RTQD-----------------------------------------
--------------------------------------------LAPLKN-PSGEENENV
TKTHDK--PVKEDVGYL-----------------------------------GEDPEATI
TQNNESFWEIPNSLTPEDGDNSSETT---------------D------------------
--------PPVQGDSQ------------------NKVDPLRESM---------ERSHNNN
PDT---------------------------------------------------------
------------------------------------------------------------
---------------------------------------------KKQVALGEESRTQEA
V------VLEVRG-----------------------------------------------
---EDKLTEESEWAAREEYR-S--------QGLG-----T-KDQGPAVHPDGHPEAQ---
---KSISRG--ENRKSLETEIPGTLEAD--VTDQSSIRQLSAEED---------------
-------------------SRKKLKAQSPSTKGEESRAQETQEAPVKNLDD-NSASS---
--KAHFERDE-------PATL--EEDEGPQYLAGEANDQQNPAKK-GYDVSVPQSSLVEK
MQMDQESGSVERSTIYSSPLYQYLQEKILQQMDMTPV--------------------EQQ
N---------------------------------QALSARASSPE---------LLNNQS
SASLTSEGSDCPIIFSDSQALQ---------------YYNWEHLPDADPSDAQQTSAPQA
S-DMQGHPQEKKSVLQREASTK----------------------------------K---
-----------------------------Q------------------------------
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-------------

----------------MAQLQENINGIITTFYTYASSDGD-CSTLSRGELRQLIEQEFED
VIMDARD-----------PRTVEKVLLFLDEDSSGKVDFS-----------E-FLN-L--
-V---------------F-R-V-A-K-A-C-HGQ----LQQ---Y-LEP-EDDQELTVQE
EADGEQ--HHKQVLEEGVSEQVREGGTSQQD-----------------------------
---------------------Q------------------------------------DT
QQHQKGEEPK----KHQDTQQNQ-EDGTPKN-QDT---QKTEKSETPKIQDTQKTQEVE-
-TPKSNQGTQ------QKQ------KSE--MPKNVHQDDRA-------------------
------------K------------A-REEGP---KRGENVVTETSEKDRNTQKIEKIPK
H--DP-------------------------------------------------------
------------------------------------------------------------
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-------------

----------------MPQLLRHVLCVIETFHKYASENG---DSLTCRELKQLFQREFGD
FLQPHV------------IHAVEKNLNLLDIDNYDTISFD-----------E-FIL-G--
-I---------------F-N-L-L-N-V-C-YLD----IQS-----LLN---S-EPRP--
-EE------KSND------VDLQGTP---RN---------GQQTAR---TLPT-------
-----------QENV----------------IFPS----------------------RIA
LSTPVRSEES----------------EIVRYNRVD-PWGDNNTHNQP-EAPMYNNP----
---KNQHL-------------------------------------------------EGN
-------KQSQGVVQDIPATEDXXXX-XXXXX---XXXXXXXXXXXXX-XXX-XXXXXXX
XXX-XX----XXXXXXX------XXXXXX---------------XXXXXXXX--------
--------------------------------------------XXXXPPEEITQ-RSE-
-----------------DQ----------EVAIEK-GIKK-----------SKRKEPPL-
------Q-------------------KDE-P-------------ISEHA---DLP-----
EQAAASKPSQTQ---KSNDSEDD--SRT----PHTQEPGKEAD------------RTLHE
------------TTN--VHEPEDYGR---------------------ISETQEPPA----
------------------------------------------------------------
------------------------------------------------------------
------------------QDGETKSPSVQGGSRNV----SETPGLD--------TKREEV
RDPETHKTAGQ-RE----------------------R---------------------KT
QSSAL-------------KAQTQSEKY--EKLQDSS-------KEKEAVKGSET------
-----------------------------------------QELNSEGGNQN-----HPE
I--------------E-------GI----A-VPGEEAKFSEEDTAEAFANNKNGPAAEGT
PGTGE----------RTQK-----------------------------------------
--------------------------------------------LTPLEN-QSKGKN-GV
TKTHNK--PIKEDSGYQ-----------------------------------GKDPESLL
KQNDERSSETPNSLAPEEGNSNSET-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----HLETEE-------PATL-EEENEDPQKLT-EGDDQQIPGKT-KYNSSVPQSGLEEK
TQRDQDASCVERGAVHSSPLHHLLPGMILQQTDVTPE--------------------EHK
N---------------------------------QAQTMQASD-E---------PGNDQS
RATLSSKVSDCPVFLNCSQVSQ---------------QYTQEFLSDEDSADTQHTSTPQA
LEN-KGHPQREKPVPQREVSTT----------------------------------K---
-----------------------------Q------------------------------
------------------------------------------------------------
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-------------

----------------MPQLLNSILNVIEVFQKYAKENGD-CASLCKEELKQLLLAEFGD
ILRRPND-----------PESVETIMSLLDRDRNGHVDFH-----------E-YLL-L--
-V---------------F-Q-L-V-Q-A-C-HHK----LDN---K-PCG---D-------
KTSR-QERGQE-R-----TQDHKFPGN-TGR---QH----RQRHEEERQ-----------
-DSHYS-QSERQ---------------HEDSH--------------------------SG
QSERQGQDS--HY-SQSERQGQDSRYGQSERQRQG---SHYGQSERQRQGSHYGQSERQR
QDSH------------------------YGQSERQRQDSH--------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------YGQSERQH
QDSHYGQSERQR------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------QD
-------------------S--RYG-------------------------------QP--
---ER----QRQDSHYGQFERQR--------------------------------QDSHY
GQSERQDEDYSFDQSERQVQ----------------------------------------
-----DSYYGQ-------------------------------SERLGQQSSC-G--QS--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------GRLGQDSYHSQTNQQESGSYY--
-----------GQSGRADQESGCAQKDR--------------------------------
----------------QGLD-----------------SHYGQTDRQGLSSQYGQTDRQGQ
SSRD--GQTDRQGLSSQYSQTDRRSQNSYYGQTDRQGLGSQYGQTHRQNQSS--------
----------HYGQSQTGKT------------EIQRPNRYFQGTEG-TR-----------
--R-DSYVEQSGRSGRLSQQTPGQEVY-QNQQQGFQSRDMQQDSHQVWEP----EEDNQ-
-----------HHQHKLLALI--QQEKP--LCHKGRDGQSCSS-----------------
-------------------EQGHRQAQTRHSQSE--------------------------
------------------------------------------------------------
--------------------------G---------------------------------
------------------------------------------------------------
----KSHRA------EEEQSHQ-----------------SWGRHSHGGLESPWEAQDRQT
WEDEQNRQRQDRQTHKDEQNHQ--------------------------------------
--RRDKQTWEDEQNH-Q-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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----------RRDRQTHEDEDEQNHQ----------------------------------
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-------------

----------------MTDLLRSVVTVIDVFYKYTKQDGE-CGTLSKDELKELLEKEFHP
VLKNPDD-----------PDTVDVIMHMLDRDHDRRLDFT-----------E-FLL-M--
-I---------------F-K-L-T-M-A-C-NKV----LSK---E-YCK---A-------
SGSKKHRRGHR----------HQEEESETEED--------EE-------DTPE-----HK
SGYRHSSWSEG-EEHGYG---SGHSRGTVKRRHGS-----------------------N-
-SRRLGRQG------------------------NLSSSGNQEGSQ-KRYHRSSS------
---------------------------GHSWS--------S--GKERHGFSS-GELRERI
N--------------------------KSHV-------------SPSR----EF-----G
EEYESG-------------------SG---------------------------------
--------------------------------------------SKSWERKGHGGLSCGL
EIS--GH-----E-SNST---------QSRSR-GQKLGSS-----RSCSGDSRRRSHACG
YS---------------------------------------------------------N
SSGCGRP---QN---ASNSCQSHRFGGQVNQSSYI-QSGCQSVINGGQGHDCVSGGQPSG
CGQ-----PESNSCS-QSYSQRGYGA----------------------RENGQ--PQNC-
GGQQRTG--SSQSSFCGQY-----------------------------------------
-----------------------------------------------E-------S----
-GGSQSCSNGQH-----------EHGSC-GRFSNSSS----SNEFS--------------
---KC--------G--KHRSGSGQF------T-SCEQ-----------------------
---------------------------------------HGTGL----S-----------
---QSSG---------FEQQVA---G-----------------SSQTCSQY---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------GSRSSQS-
------------SGYDE-HGSSSGK-----------------------------------
-----TSGFGQHRSGSGHSSGFGQHG-----------SGSGQSFGFGQ------------
------------------------------------------------------------
----------------------H---G----------S------GSGQSSGFG-------
----------QH-ES-------RSC-----------------------------------
-----------------------QS-S-----Y---------GQHGSGS-----------
------------------------------------------------------------
-SQSSGYGQ--HA---------------------S-------------------------
----------------------------------R-------------------------
---------------------------QTSGFGQH-----GL------------------
------------------GSGQSTG-----------------------------------
------------------------FGQYGSG------SGQSFG-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------FGQH-----------------------
-------GSGSGQSSGFGQHES-RS-G-QSS--------------------YGQHS-SSS
------------------------------------------------------------
------------------------------------SQS----------T---------G
FGQYG-SGL-GQ--SSGFG-KHE-STSGQ------------------S------------
--------------------------------S-Y-------------------------
------------------------------------------------------------
-------G--------------------------QH-GFG--------SS-Q--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------SSGFGQHGS-GSG-QSS-GF---G
QH-ES-RS-RQ-SSY-G-QHGS-GS-SQ-SS----------GYG-QHGSKW--TSGFGQH
-SSGSGQ---------STSFGQYGSGSGQSSGFGQHGSGSGQSSG--------FG-----
----------QHESRSGHSSCGQHGFGSSQSSGCGHNGSSSGQT-SGFGQHELSSGQSSS
FSQHGSGLGQSSGFRQHGSGS------------------------GQSSGFGQH------
ESRSHQ------------------SSYGP---HGSGS------------------G----
----------QSSGYGQHGSS---------SGQASG------------------------
------------------------------------------------------------
-----FGQ------QGS----SSSQ----Y------------------------------
----------------------------SGFG----------------QHGS-------G
L------G----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------QS--S
G-FGQ-H-----------GT-GSGQFSGFGQHES-RSHQSS-YGQHGS-GSSQ-SS----
---GYGQHGSS-SG--H--TTGF-GQ-------------HRS---SS---GQYSGFG-QH
GSGLG---QSSGFGQHGTGSGQSSGFGQHE-SRSH--------QS--SYGQHGSG--SSQ
SSSYGQHGSSSGQTSR------------FGQHRSGSGQSSGFGQYELGSGQSSGFGQHGS
GTGQSSGFA--------------RHEYRSGQ-SSYGQHGTGSSQSSGCGQRESGSGP---
-------------------TTGFGQHVSGSDNF---------SSSGQHISGSGQSTG---
------------------------------------------------------------
-------FGQYGSGSGQSTGLGQGESQQVASGSTVH------------GRQETTHGQT--
--INTARH------SQSGQG---------------QSTQTGSRVSRRRR-SSQSENSDSE
VHSRVSH----RHSEHIDTQVGSHYPESGST-----------------------------
------------------VHRRQGTTHGQR-----------------------GDTTRHS
HSGHGQSTQTGSRTTGRQGFSHSDATDSEVHSGVSHR---------PHSQEHTHGQDGSQ
LGESQSTV----------------------------------------------------
-----------------------HERQETTYGQTGD------------------------
------------------------------------------------------------
----ATGHGYSGHGQSTQIGSR--TSGRRGSGHSES-SDTEVHSGGSHRPHSQEQTHGQA
RSQHGESGS--SGHGRQGTTHGQSGDTTRY----AHY---HNGQSTQRGSRTTG-RG-SG
HSEYSDSELYS-----------------------------------------GGSHTYSG
HTHGQAGSQHGESDSIVHERYGTTHGQTGDTTRHA---------------------HYGH
GQSTQRGSRTTGRRGSGHSDDVQAL--GGGSTRIQDRL----------------MA---S
RIPTWE-------------------------------------------------RYTPR
HDQSG---------------HGQSTQTGSRTTEEGDL-----------------------
------------------------------------------------------------
-ATVSTSDSEGHSGGSHTHSG-----H-THAKPDP----------TWRGTIHGQTGYTTR
HGPV----WVMAV-------------------------HYRQGFQDNWKKGIVATVSTVT
VKGT-----------------------------SGISHTHSGHTPWAKRIQH------GE
VRI------CRSSGDRELYMDRQEIPPRHGQSGHDESIQK--GSQDNWKGRGSGHSEARQ
G------SHTP-------------------------------------------------
------------------------RFRYTTHAKLDLNMEIQDPAGHGRQGTTHGQTGDTT
RHAHYGHGQSNTERVRT-----------------------------------------AG
RRGSGPQTHSMAKPDLNM------------------------------------------
--ESQRSTVHERQQTTPWKTRRYPQTCHLWSWTI-------HTERP--------------
-------------------------QDSWKKGIWHSEYSDSEAH--SGVSHTHSGH----
-------------------------------NSWPKPDPKHGES----GSAVHERQGTIH
GQTGDTHSDM------ASLIM------ERTTGRRGSG-----QREYSDSEGQLSGLTH--
---------------TFRTT----------------------------------------
--LHG------QESG---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------SAVHGRQGTIHGQTGDTTRH-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------AHYGH---------------GQSTQTGSRTTGRRGSGHSEYSDSEGHSGGSHTH
L-----------------------------------------------------------
-------------------------------------------------GHTHGQAGFQH
GDH--------------------------GQTTQTG-----SRTTG--------------
------------------------------------------------------------
--------------RRGSGHSEYSDSEGHSG-GSHTHSGHTHGQAGS-------------
----------------------QHGESGSAVHGRQGTIHGQTGDTTRHAHYGHGESIQTS
---S-------RTIGRRESGHS------------E-------------------------
-----------------------------------------YSDSEGHSVG---------
-----------------SHT--HSGHTHGQAGSQHGESG----SVIHGRLETTHGQTGDS
TRHGHSGYGQSTETGSRST--R---TSHFQSH--SSERQRHGSSHVWK---HGSYGPAE-
-------------------------------YDYGHTGYGPSGG-RRK-SICNSHLLWSI
DSATNE--QLSRH-----------------------------------------------
------------------------------------------------------------
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-------------

----------------MAQLLSSILSVIEVFHKYAKENGD-CALLCKEELKQLLLAEFGD
ILQRPND-----------PETVETILNLLDQDRDGHVDFH-----------E-YLL-L--
-V---------------F-Q-L-V-Q-A-C-YRK----LDN---K-SYG---G-------
RTSQ-QERGQE-G-----AQDRKFPGN-TGT---QH----RQRHEEERQ-----------
-NSHHS-QSERQDRD---------------SH--------------------------SG
QPERQDRDS--HH-GQAERQDRDSHHGQP---------------ERQDRDSHHSQPERQD
RDSHHSQPERQ------------DRDSHHS------QPER---QDRD--SHH--SQPE--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------RQDRDSHHSQPERQDRDSHH---GQAERQDR
DSHHGQAERQD---RDSHHGQPERQD-R--D------S-----------HHSQPERQDRD
-------------------S--HHS-------------------------------QP--
---ER----QDRDSHHSQPERQD--------------------------------RDSHH
GQPERQDRDSH-------------------------------------------------
--------NGQ-------------------------------PERQDRDSH---------
------HNQSERQD---KDFSFDQSERQSQDSNSVSHKSTRVQDSHYGQ---S---E-RL
------------------------------------AQQLGQEFGCGQMDR---------
------QDQSYH----YGQTDR--QDQSSH-----YSQMDRQGQSSHYSQTDRQGPSSH-
------------------------------------------------------------
------------------------------------------------------------
-------------------YGQTDRQGQSSHYGQTDR-----------------------
-----------Q------------------------------------------------
---------S--------------------------------------------------
-----------------------------QSSHYGQTDRQGQSSHYGQTDRQGQSSHYGQ
TDR-QGQSS------------HYGQTDR--------------------------------
----------------QGQS-----------------SHYGQTDRQGQSSHYGQTDRQGQ
SSHY--SQMDRQGQSYHYGQTDRQGQSSHCGQTDRQSQSYHYGQTDRQGQSS--------
----------CYVQSQT---------G---EI--QGQNKYFQGTEG-TR-----------
--K-ASYVEQSGRSGRLSQQTPGQKGY-QNQGQGFQSRDSQENIHQVWEP----EEDSQ-
-----------HHQHKLLAHI--QQERP--LCHKGRDWQSCSN-----------------
-------------------EQGHRQAKTRQSHGE--------------------------
------------------------------------------------------------
--------------------------G---------------------------------
------------------------------------------------------------
----QSHWA------EEEQGHQ-----------------SWDRHSHEGQEGPCGTQDRQT
PEDEQNHQRRDRQTHEDEQNHQ--------------------------------------
--RQDRQTHEDEQNR-Q-------------------------RRDRQTYEDEQNHER---
------------------------------------------------------------
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-------------

----------------MSPLLRSICDITEIFNQYVSHDCD-GAALTKKDLKNLLEREFGA
VLRRPHD-----------PKTVDLILELLDRDRNGRVDFN-----------E-F-L-L-F
-I---------------F-K-V-A-Q-A-C-Y--Y-A-L-G-Q-A-TG--L-D------E
E-KRA-R-C-D-G-K-V-SL-L--QD-RRQEED-Q-R-----------------------
-------------------------------RF-------------------------ES
RDRQLEEEPG-----QRRRQKRQE----QER--EL-AEG-EEQSEKQE-RLEQRDR----
--------------QRR---------DEELWR------------------Q-RREWKEQE
E--R----------------RAEEEQ-LQRCK-------------------GHETEAFPD
EE-QQR----RRELQ---------------------E---LRRERREEKQQQRR------
-------------E------------------R--QERVLQEEEEKEW-RKRERVLRQEE
-----------------------------K------LQEE-------------E--PQL-
-----QRELQE-EEEQL--------QKLERQ---------------------ELKRERQA
EE----Q--QQQ---RLRREREEERREQ-QL-RREQEEER--------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------REQEERREQ--RL
KRE-------QE-----------ERRDW--------LKREEEEERR--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------EQLLKREEKERLQ--------------------
------------------------------------------------------QDRREQ
RLKRGQEE-ERRDQLLKREE-EEERLEQEERR--EQRLKR-EQ-------EE--------
----------RREQRLKREEEERLEQEER-R-E-QLE-ERRQ-QWLTR----EQEL----
---------------A--EE---KQE---------------QA-----RERIKSQTPKWQ
WQLESE-------------------------------ADARQSK---VYSR---------
PRK-QEGQ-----RRRQEQEEKRR------------------------------------
-------------------RRER---E----------L---------QW---Q-------
----------EEEPARRQQQEEEQRGDFTWQWQAEE-----ERQRGRQRLS---------
-----A-RPSLREQRERQLRAEER----------QQPEQRFLQEEE-KEQRRR--QRSE-
REKELQFLEEKEQLQRRERAQQLQEEGYGSQEDQERRRSPEQRRDQKWRWQ--LEEER--
-K---------RRHHTLYA-------KP------ALRGQLRKEQQ----L-----LQQE-
------E-EQLQ--REE-REKRRRQEQERQYREE-EQL-QQEEEQLQ-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------QEEE-QLLREE--
-REKRRRQERERQYREDEELQQEEEQLLGE--------------E---------REK-KR
RQERERQYRKEDELQQEEEQLL-------REEREK---RRRQERERE-------------
------------------------------------------------------------
------------------YREEEEL---QQEEEQL---LREE------------------
------------------------------------REKRRRQELERQYREEEELQ----
--Q-------------------------------EEEQLL---RE--EREK-REQQ----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
LR---------RQE----------------------------------------------
------------------------------------------------------------
------------------------------------------------------RDRKFR
E-----------------------------------------------------------
----------------------EEQQLRPQ------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------ERERKFLQE
EQQLR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------RQEL------ERKFREEEQLRQE-------------------
-------------TEE-E-QLRRQERDR-KFLEEEQLRQEREE-------QQLRRQER-D
RKFREEEQLPQEREEQ--QLRRQDRERKYRWEEEQLQL----KKQE--------------
------------------------------------EQRLRQE-----RDGQYRGEE---
-----------QFATQEKSRRQAQELWQEEEQKRRQERERKLWEEH-LRSEQEEEQRRR-
-----Q----V------RET--------QSQEGKGHGRLLE-----PGSHQFASVPV---
-------------------RSSPLYEYIQEQRSQYRP-----------------------
------------------------------------------------------------
------------------------------------------------------------
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-------------

----------------MPQLLQNINGIIEAFRRYARTEGN-CAALTRGELKRLLEQEFAN
VIVKPHD-----------PATVDEVLRLLDEDHTGTVEFK-----------E-FLV-L--
-V---------------F-K-V-A-Q-A-C-FKT----LSESP-EGACG---S-----QE
SGSL-----HS-G----ASQELGE-GQRSGTEV--GRAGKGQHYEG--------------
-------SS-------------------------------------------------HR
QSQQG-----------SRGQNR---------------PGVQTQG----------------
------------------------QATGSAWVSSYDR------------------QAESQ
SQERI-SPQIQLSGQTEQTQKAGEGKRNQTTE------M--------------R-----P
ERQP-----QTREQDRAHQTGETV-TGSG-------------------------------
--------------------------------------------TQTQA--GATQTVEQD
SSHQTGRTSTQTQEATNDQNRGT----------------E--------------------
-----THGQGRSQTSQ-----AVTGGHAQIQ-------------AG--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------THT-----------------------------------------------
------------------------------------------------------------
---QTPTQTVEQDSSH----------------QTGSTSTQTQESTNGQNRGTEIHGQGRS
Q---------------TSQAVT---GG--HT----------QIQAGSHTETV--------
-----------------------------------------E------------------
------------------------------------------------------------
----------------------QDRSQTVSHGGARE------------------------
---------------------------------------------------QGQTQ----
MQPGSGQRWMQVSNPEA-GE----------------------------------------
---------TVPG-------------------------GQAQTGASTESGRQEWSSTHPR
RCV----------TEGQG-----------------------DRQPT--------------
-------VVGEEWVDDHSRET---VILRLDQGN----LHT--------------------
------------------SVSSAQGQDAAQ------------SE-EKRGIT-ARE-----
----------L--------------------------YSYLRSNKP--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-------------

----------------MTDLLRSVVTVIDVFYKYTKQDGE-CGTLSKGELKELLEKEFHP
ILKNPDD-----------PDTVDVIMHMLDRDHDRRLDFT-----------E-FLL-M--
-I---------------F-K-L-T-M-A-C-NKV----LSK---E-YCK---A-------
SGSKKHRRGHR----------HQEEESETEED--------EE-------DTPG-----HK
SGYRHSSWSEG-EEHGYS---SGHSRGTVKCRHGS-----------------------N-
-SRRLGRQG------------------------NLSSSGNQEGSQ-KRYHRSSC------
---------------------------GHSWS--------G--GKDRHGSSS-VELRERI
N--------------------------KSHI-------------SPSR----ES-----G
EEYESG-------------------SG---------------------------------
--------------------------------------------SNSWERKGHGGLSCGL
ETS--GH-----E-SNST---------QSRIR-EQKLGSS-----CSGSGDSGRRSHACG
YS---------------------------------------------------------N
SSGCGRP---QN---ASSSCQSHRFGGQGNQFSYI-QSGCQSGINGGQGHGCVSGGQPSG
CGQ-----PESNSCS-QSYSQRGYGA----------------------RENGQ--PQNC-
GGQWRTG--SSQSSCCGQY-----------------------------------------
-----------------------------------------------G-------S----
-GGSQSCSNGQH-----------EYGSC-GRFSNSSS----SNEFS--------------
---KC--------G--QYGSGSGQS------T-SFEQ-----------------------
---------------------------------------HGTGL----S-----------
---QSSG---------FEQHVC---G-----------------SGQTCGQH---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------ESTSSQS-
------------LGYDQ-HGSSSGK-----------------------------------
-----TSGFGQHGSGSGQSSGFGQCG-----------SGSGQSSGFGQHGS---------
V-----------------------------------------------------------
-------------SGQSSGFGQH---G----------S------VSGQSSGFG-------
----------QH-ES-------RSR-----------------------------------
-----------------------QS-S-----Y---------GQHGSGS-----------
------------------------------------------------------------
-SQSSGYGQ--YG---------------------S-------------------------
----------------------------------R-------------------------
---------------------------ETSGFGQH-----GL------------------
------------------GSGQSTG-----------------------------------
------------------------FGQYGSG------SGQSSG-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------FGQH-----------------------
-------GSGSGQSSGFGQHES-RS-G-QSS--------------------YGQHS-SGS
SQSSG-YGQHG-------------------------------------------------
------------------SRQTSGFGQHGSGS----SQS----------T---------G
FGQYG-SGS-GQ--SSGFG-QHV-SGSGQS---SGFGQHESRS--GHS------------
--------------------------------S-Y-------------------------
------------------------------------------------------------
-------G--------------------------QH-GFG--------SS-QSSGY----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------GQHG--------SSSG-QTSGF--GQHEL------
-------SSG------------QSSSFGQHGSGSGQSSGFGQHGS-GSG-QSS-GF---G
QH-ES-RS-GQ-SSY-G-QHSS-GS-SQ-SS----------GYG-QHGSRQ--TSGFGQH
-GSGSSQ---------STGFGQYGSGSGQSSGFGQHGSGSGQSSG--------FG-----
----------QHESRSHQSSYGQHGSGSSQSSGYGQHGSSSGQT-SGFGQHRSSSGQYSG
FGQHGSGSGQSSGFGQHGTGS------------------------GQYSGFGQH------
ESRSHQ------------------SSYGQ---HGSGL------------------S----
----------QSSGYGQHGSS---------SGQTFG------------------------
------------------------------------------------------------
-----FGQ------HRS----GSGQ----S------------------------------
----------------------------SGFG----------------QHGS-------G
S-------GQS-SG----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--FGQ-H-----------ES-GSGKSSGFGQHES-RSSQSN-YGQHGS-GSSQ-SS----
---GYGQHGSS-SG--Q--TTGF-GQ-------------HRS---SS---GQYSGFG-QH
GSGSG---QSSGFGQHGTGSGQSSGFGQYE-SRSR--------QS--SYGQHGSG--SSQ
SSGYGQHGSNSGQTSG------------FGQHRSGSGQSSGFGQYGSGSGQSSGFGQHGS
GTGKSSGFA--------------QHEYRSGQ-SSYGQHGTGSSQSSGCGQHESGSGP---
-------------------TTGFGQHVSGSDNF---------SSSGQHISYSGQSSG---
------------------------------------------------------------
-------FGQYGSGSGQSTGLGQGESQQVESGSTVH------------GRQETTHGQT--
--INTTRH------SQSGQG---------------QSTQTGSRVTRRRR-SSQSENSDSE
VHSKVSH----RHSEHIHTQAGSHYPKSGST-----------------------------
------------------VRRRQGTTHGQR-----------------------GDTTRHG
HSGHGQSTQTGSRTSGRQRFSHSDATDSEVHSGVSHR---------PHSQEQTHSQAGSQ
HGESESTV----------------------------------------------------
-----------------------HERHETTYGQTGE------------------------
------------------------------------------------------------
----ATGHGHSGHGQSTQRGSR--TTGRRGSGHSES-SDSEVHSGGSHRPQSQEQTHGQA
GSQHGESGS--TVHGRHGTTHGQTGDTTRH----AHY---HHGKSTQRGSSTTGRRG-SG
HSESSDSEVHS-----------------------------------------GGSHTHSG
HTHSQGGSQHGESESIVHDRHRITHGQTGDTTRHS---------------------YSGH
EQTTQTGSRTTGRQRASHSESTDSEVHSGGSHRPHSREHTYGQAGSQHEEPEFTVHERHG
TTHGQI-------------------------------------------------GDTTG
HSHSG---------------HGQSTQRGSRTTGRQRS-----------------------
------------------------------------------------------------
-SHSESSDSEVHSGVSHTHTG-----H-THGQAGSQHGQSESIVPERHGTTHGQTGDTTR
HAHY----HHGLT-------------------------T-QTGSRTTGRRG-SGHSEYSD
SEGY-----------------------------SGVSHTHSGHTHGQARSQH------GE
SES-------IHERHGT-IHGQTSDTTRHAHSGHGQSTQT--GSRTTG-RRSSGHSEYSD
SEGHSGFSQRP-------------------------------------------------
------------------------HSRGHTHGQAGSQHGESESIVDERHGTTHGQTGDTS
GHSQSGHGQSTQSGSST-----------------------------------------TG
RRRSGHSESSDSEVHSGGSHTHSG---HT----------------HSQAR---------S
QHGESESTVHKRHQTTHGQTRDTTEHGHPSHGQT-------TQTGS--------------
-------------------------RTTGIRGSGHSEYSDSEGP--SGVSHTHSGH----
-------------------------------THG-QAGSHYPES----GSSIHERHGTTH
GQTADTTRHGHSGHGQSTQRG------SRTIGRRASG-----HSEYSDSEGHS-GVSH--
---------------THSGH----------------------------------------
--AHGQAGSQHGESG---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------SSVHERHGTTHGQTGDTTRH-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------AHSGL---------------GQSTQRGSRTAGRRGSGHSESSDSEVHSGVSHTH
S-----------------------------------------------------------
-------------------------------------------------GHTYGQARSQH
RESGSAIHGRQGTIHGQTGDTTRHGQSGHGQSTQTG-----SRTTG--------------
------------------------------------------------------------
--------------RQRSSHSQASDSEVHSE-ASPTHSGHTHSQAGS-------------
----------------------RHGQSGSSGHGRQGTTHGQTGDTTRHAHYGYGQSTQRG
---S-------RTTGRRGSGHS------------E-------------------------
-----------------------------------------SSDSEVHSWG---------
-----------------SHT--HSGHIQGQAGSQQRQPG----STVHGRLETTHGQTGDT
TRHGHSGYGQSTQTGSRSS--R---TSHFQSH--SSERQRHGSSQVWK---HGSYGPAE-
-------------------------------YDYGHTGYGPSGG-SRK-SISNSHLSWSI
DSTANK--QLSRH-----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-------------

----------------MPQLLRNINGIIEAFRRYARTEGS-CTALTRGELKRLLEQEFAD
VIVKPHD-----------PATVDEVLRLLDEDHTGTVEFQ-----------E-FLV-L--
-V---------------F-K-V-A-Q-A-C-FKT----LNESP-EEACS---S-----QE
SGSL-----HS-G----AWQELSE-GQRSGTEV--GRAGKGQHYEG--------------
-------SS-------------------------------------------------HG
QSKQP-----------SRGQSR---------------PGAQTQG----------------
------------------------QATGSAWVSSYDR------------------QAESQ
SQERT-SPQIQRSGHTEQTQRAGEGKRHQTTQ------M--------------R-----P
ERQP-----QTREQDRAHQTSETV-TGSG-------------------------------
--------------------------------------------TQTQA--GATQTVEQD
SSHQTGRTSSQTQEATNDQNRGI----------------E--------------------
-----IYGQGRSQVSQ-----AVTGGHAQIQ-------------V---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------GTHT-----------------------------------------------
------------------------------------------------------------
---QTPTQTVEQDSGH----------------QTESTSTQTQGSTNDQNRGTEIQGQGGS
Q---------------TSQAVA---GG--HA----------QTQAGSHTQTV--------
-----------------------------------------E------------------
------------------------------------------------------------
----------------------QDRSQTISLGGAGE------------------------
---------------------------------------------------QGQTQ----
TQPGSGQKWTQVSNPEA-GE----------------------------------------
---------TVPG-------------------------GQAQTGASTESGRQEWSSTHPR
HNV----------TEGQG-----------------------DIQPT--------------
-------VVGEEWVDDHSRET---AIFRFDQGN----LHT--------------------
------------------TVSSAQGQDAAQ------------PE-EKQGIT-ARE-----
----------L--------------------------YSYLRSNKP--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-------------

----------------MPHLLQSIVTVIDIFYQYSSQDGK-CDMLKRGELKELIQNEFRQ
ILKNPDD-----------PDTVDIIMQSLDRDHNKKVDFI-----------E-YLL-M--
-V---------------F-K-L-A-Q-A-C-NRI----ISK---D-YCQ---A-------
SGSTQKDHRNW----------HQEEQSETEEE--------N---------K-------QG
RSSTHSSWSAG-ENDSYS---RSP-RR---------------------------------
------------------------------------------------------------
----------------------------------------S--TKLRSGYGS-SFL----
----------------------------------------------------NR------
---ERE-------------------SSAGS------------------------------
----------------------------------------QSE-SYEEQGYNSSSSETS-
---VYGK----HK--------------------------S--------------S-----
--------------------QSPSQRRHGSYLSGQS------------------------
--------------------------------------------GSNSDKHNSESSQSSG
-------------SG-EYGSE-----S--------------------GQ-----------
------------SINQGKS----------------K------------------------
----------KC------------------------------------------------
--PCQSSSHGKY-----------GSSS--------------------------------R
QQ----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------SGSYE-----------SGSGKHSNRGXX-X---------
X---XXXXX-----------X---------------------------------------
------------------XXXXX---X----------X------XXXXXXXXX-------
----------XX-XX-------XXXXXXX----------------XXXXXXXXXXXXXXX
XXXXXXXXXXXXX------X-XXXX-X-----X---------XXXXXXXXXX--------
------------------------------XXXXX-----XXXX------XXXXXXXXXX
XXXXXXXXX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XX--------XXXX----------
---XX--------XXX-X--------XXXXXXXXX-----XX------------------
------------------XXXXXXX-----------------------------------
------------------------XXXXXXX------XXXXXX----------------X
XX-XX-XXXXXX----XXX-XXXXXXXXXXXX--XXXXXXXXX-----------------
-------XXXXXXXXXX-------------------------------------------
-----------------------------XX--XXXXX--XXXXX-XXX-----------
-------------X---XXXX--XXXXXXXXXXXXXX-----------------------
-------XXXXXXXXXXXXXXX-------------------------XXXXXXXX-----
-----------------------XXX-----------------XXXX---------XXXX
XXX--XX-XXXXX------XXXXXXXXXXXXX----XXXX---------X---XXXXXXX
-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XXX---XXXXX----
---------------XXXXXXXXXXXXX----X-XXXXXX----XXXXXXXXXXXXXXXX
XXXX---X----------------------------------------------------
-----XXX--------------------------XXXXXX-------XXXXXXXXXXXXX
X-----------------------------------------------------------
------------------------------------XXXXXXXXXXXXXX-XXXXXXXXX
XXXXXXX---XXXXXXX-XXXX-----------XXXXXX-X-----------XXXXXXXX
XXXX---------XXXXXXXXXXXXXXXX--------XXXX-XXXXX--XXXXX------
-------XXX------------XXXXXXXXXXXSG------------Q--SQWLDQ----
---------------------------------------------Y-GSRLGQSSSYSQH
-SSS--Q---------SSSHRHYRSGSGQSGGSGQYGSGFGHST--------SYG-----
----------QHG-SSQSSTRGHHGYGSGQSSSHGQCGSSSGQS-SNCSQHGSGSGQYG-
-----SVS----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------GQSSSYG-----SSQSSRHRRHG-SGSG--------QSP-SYGQQSS----SH
SS-------------S-----------H-RHHRSGSGQSSGSGRYGYGSGQSSGYSQQSS
--NQSSSHR--------------HHGYGSGQSSSCGQHGSSSGQSSSCGQHGSGSRQYGS
G----SGQSSSYGQHGSSQSSTHGHHGYGSGQS---------SGSGQYGSGSGQSSSYGQ
QGSSQSSSH--RH-----------------------------------------------
-----------------------HGSSLGQSSS-GGQYGSSSGQSSSWGQHESGLGQS--
--SGSGQYGS--------------------------------------------------
------------------------------------------------------------
----------GSGQ--SSSYGQQGSSQ---------------------------------
------------------------SSSHGRHGSTSHQSSSYG------------------
----------QHES----------------------------------------------
-------------------------------------------SLGHSSSYGQHGSGSGQ
S-----S-----------------------------------------------------
-----------------GSGQY--G-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
SGSGQP-SSYGQQS--SS--HSSSHRHHGSGSSQP-SSCGQHGSSSGQSSSCGQ------
--------------------------H-----------------GSGS--GQYSGSGQYG
SGSGQSS-----------------------------------------------------
---------------------------------------SYGQH----------------
------------------------------------------------------------
----------------------------GSSQS--S-------THEHPVSGSGQSSGS--
-GQY----------------------------------------------GSGSGQSSSY
GQQG--------------------------------------SSQ--SSG----------
----------------------------HRHRGS-SLGQSS----SG-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--GQYGSS----------------------------------------------------
-----------------------------------SGQSSSWGQHES-GLGQSSGSGQY-
----GS-------------GSGQSSSYGQQGSXXXXXXXXXXXXXXXXXXXXXXX-----
--------X-XXXXXXXX----------------XX------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---XXXXXXXXXXX-----------X----------------------------------
-----------X-XX-------X-------------------------------------
------------------------------------------------------------
-XXXXXXXX--------------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XX--XXXXXXX------XXXQYSGYEQC--------------------------------
-------------GSRSQE-C---------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------RSGCDSNYDHLGF------G--FGQ---------SVSN---------------
-------------------------SSFER--------G-KQHDYCYQKEGNYRGESTNS
RSHGFLSS-------------------------------------------------TPL
Y------------------E----------YFQEQR-YF---------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-------------

----------------MPQLLSSILNVSKVFQTYAKQNGE-CSSLCKKEFKQLLFTELGD
ILRRPND-----------PETVETILDHLDRDRNGYIDFR-----------E-YLL-L--
-V---------------F-Q-L-V-Q-A-C-HHK----IDS---K-LCG---D-------
RTSP-KERRRE-G-----TQRHEFSGN-TDR---QH----RQRHEAERE-----------
-NSHSS-QSEGQGESVQH--DK--------------------------------------
----------------------------SQKQDRD---SHLGHFEKQDSDSNYDHSERQD
TDYSSDQSEKE------------DQHSSSGQKASY-------------KSSS--DQSKSQ
G--HI-------F-------------ALNQSE------QL------AQ-----------V
PYYGQS-----------------KRFGQQI------------SHGQ-PRRLR--------
--------QDSWSSQTS----------Q-----QGSSSYEQYG-R---------------
------------------------------------------------------------
----------------------------------------------------------HQ
ESGHSQTDRQG---QSSHYGQTDRQG-Q--S------S-----------HYGQIDTQGQV
-------------------S--HYG-------------------------------ET--
---DR----QGQSCHYGETDRQG--------------------------------QDSHY
GQTDGQGQISHYGQTNGQGQ----------------------------------------
-----ISHYGH-------------------------------TDRQGQSCHY-G--QTDG
QGQVSHYGQTDRQG---QISHSGQT-------------YRQGQRSHYGQ---T---D-RQ
GQV---------SHYGQTDGQG-------QISHYGQTDGQEQISHCGQTDR---------
------QEQISH----DGQTDT--QGQVSH-----HDQTERQGQISHYSQTDGQGHIFH-
------------------------------------------------------------
------------------------------------------------------------
-------------------RGQIDEQGQISHYGQTDR-----------------------
-----------Q------------------------------------------------
---------GQVSHYGQ-TD-----------------------------G----------
---------------QGQISHSDQTDRQGQISHYSQTDRQGQISHSDQTDRQGQISHYSQ
TDG-QGHIFHRGQIDEQGQISHYGQTDK--------------------------------
----------------QGQS-----------------SHYGQTDRQRQISHYGQTDRQGQ
RSQY--GQTDRRGQSSQYGQTDRQGQSSQYGQTDRRGQSSHYGQTNRQGQSS--------
----------HYGQTDGQAQSSHCGQS---QIGKTEI-----------------------
-----------QGQNRLSRQTSGGEVN-QTQRQRVWSRGEQQTSYQTRTP----E---K-
-----------NNQHKLLAQI--QQEEP--HFHKERDWQSDSS-----------------
-------------------EQGH-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------WA------E-EEHHQ-----------------CWGRHSHEDQESLCEIHDRKT
HEEKQSHQTRDGKTHGDEQNYQ--------------------------------------
--RQHRKTHEEKQHHYQ-------------------------QQGRQTHEDEQNHQRKHR
QTHKDQ-------TCH--------------------------------------------
------------QEWDKQ------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------TNEEKERHQASQDQQ----------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------SKGYSSREKSHMNED--------------
----------------------NQSLTGKWLTDDSGSQGRHFH------------PTQSG
GRSQRRKQAGNHVTKVA-NIPNPLYDYVREQTSYQH------------------------
------------------------------------------------------------
------------------------------------------------------------
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-------------

----------------MSPFLDSIATIVGVFQQHARGDGD-GSGLSRRRMRELIQREFAD
SLVKSHD-----------PQTIEKILQFLEWDGDGDIDFN-----------E-FLL-L--
-V---------------F-R-V-A-K-C-C-FWF----QPK---A-PFL-LEEEEERLQT
WERN-REVELQRDL-RVGEVEISEERRRDQRE----RRT--QNE------TDT-------
-------ELSG-E-------RE------------------------------------RV
RE----EDPADEC-GYRRRTRQEQELKVAEREREI-QEEDREERDDPRRKGRMRE-----
--RRVDHE----QEL--EQ------EVSGHRT-------------RETE-----------
E--QL-------AA-----------ISLRETR---ERQEH--EIREIEADGRRER-----
VRYERR----------REISVAA-------------------------------------
A----------------------------------EADFKVRREIQEREPREELRRRERP
C---DDE-----EEAEAE----------------R-RISQ-------------VREREG-
-----AVRE-R-RINQE--------RE--------------------------LQ--GSL
RH-------------------------T----RE-REEEVAAN------------GRRET
R----------DTQEMREIE--ADGRR--------------------QRETLRFE-----
-RERETSA---AAAEA---DVKV-----RREIREREPREELRRRERPCDD-EEEAE----
A----ERRISRVREREEAV----RERRINQERELELEASERRTRERFERERETSVA----
---AEA---DVK-----------VRREI--------REREPREELRRRE-----RPCDDE
EEAEA--------E--RRIS---R---------------------------------VRE
RE-------------E-----------------AVRERRINQERELVLE--------ASE
Q--RTRER--EE------VAAI---GQR---------E----TRE-RYEIREIEANGR-R
QRETL---RF---------------------ERERETSVAA--EADVKVRR---------
-------------EIRERE-----------------------------------------
------------------------------------PREELRRRERPCDDEEEAEAERRI
SRVREREESVR-ERRINQERELDLEASERRTREREEEVAAIGRGDTRERREQDIRVAEA-
----DGRRRREALRFE---------------------------RE----RETSVAAAEAD
VKVRR-------------------------------------------------------
-------------------------------E-------IREREP-----REE-------
-------------EEV---AAIG---R----------R-------ETRERREQ-------
--------------DIRVAEADGRRRREALRFERER-----ET--S---VAAAKA-----
------DVKVRREIREREPREGLRR-R-----D------RPCDDEEEAEAERRISRVRE-
-------REEAVRERRINQERELELEAS------ER-RTRER------------EEVA--
-AISRGDTRERRERDIRVAEPDGRRRRE------TLR-FERDRET--------------S
----------VA--AAEADVKVRREIREREPREELRRR----EHPSEGED--RRI-----
--CPRRGREEAVKERRIDQ-------ELQLGVSEH-----RTREREEEVADV--------
---------AEADGRRQRETLRFERERETRQ-----------------------------
----------------------REALRYER------ERETSVAAEADIKVR-REIRE--R
EPREERKWRECPGEGEEEA-EAE----------------RWRECPCEGEED-RRIC----
--PRRG---REESLR---------------------------------------------
----ERRINQERELEVSEHRTR-------ESEEEVAAFRQRENRDRH-------------
--------------------E----------------------------------IREIE
---------------ADGRRQRETL---RFERERETSAAAAE-ADVKVRRGIRER--EPR
E---------------------------------ELR--R----RERNCDDEEEAEA---
------------------------------------------------------------
------------------------------------------------------------
------------ERRISRVRERE---------ESVRERRINQERELDLEASE------RR
T--------------------------RE---------------REEE------------
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-------------

----------------MPQLLRNINGIIEAFGRYAGPDRS-RCALTRGQLK--LQRELAD
VIV KPQD-----------PA TVDEVLRLLDEDHTGTVEFE-----------E-FLI-L--
-V---------------F-K-V-T-Q-A-C-FKT----LSESP-EGACG---T-----QE
SRSC-----AP-R----ASPEQGE-GQSSGPEE--ERAGGRQHPQA--------------
-------SS-------------------------------------------------GG
QSG----------------------------Q-----RGAQTQG----------------
------------------------QAPGSTQVSHRDR------------------WSESQ
GQQGG-SRQTPARGHVEPTQSAGEDQGCQTRD------E--------------R-----S
ERQS-----QAREQDRAHQTSETV-TGAE-------------------------------
--------------------------------------------TLTQT--GATQTVARD
RSQQSGGASSQSQESFQGQTRGT----------------E--------------------
-----THGQHSSQTSQ-----VVTRGHIQTW-------------GGAT------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---QTVTQTVEQNRSQ----------------QSGGTSSQSQESFHGQTGGTETHGQHRS
Q---------------TSQVVT---GG--PV----------PTQTESQSQTV--------
-----------------------------------------E------------------
------------------------------------------------------------
----------------------QDRSQTPCHTGVGE------------------------
---------------------------------------------------QGQTQ----
RQSGRGQRGTTESGHEA-EG----------------------------------------
---------TE-P-------------------------GQAQPGASAL------------
-------------TGGQG-----------------------GGRSS--------------
-------VVEREWVDDPARET---VIGRQDRGG----PCA--------------------
------------------HVPPAPGREGAQ-------------E-VKRGLA-AWG-----
----------L--------------------------NSCLEGNKP--------------
------------------------------------------------------------
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-------------

----------------MSQLLKSIVTVIDIFYHYTQGDGD-CETLSKGELKELLEKEFRP
ILKHPND-----------PDTVDVIMQILDRDHDRRVDFT-----------E-FLL-M--
-V---------------F-K-L-T-Q-A-C-NKV----VSK---D-FCP---A-------
SGSKQKSGRHT----------WGQGHPNELK-----------------------------
-GDGQSSWSAG-GQSSYG---GHGSGSGGKFTSQG-----------------------GH
GTSS-GGQSTSHG-GQGSG-SGGQ----SSHGGQASGSGVRVDMG-PVQVASQL------
---------------------------AMVDK--------V--LDQ---EVN-QVMVDKR
P--------------------------ALEV---------------------QL------
---RSD-------------------GGRV-------------------------------
----------------------------------------H---NQSWTSESEGT-----
-----------------------------QSQSG-----S-----------------ES-
-DPEGQAGKSW-------------TQTQGSGRGHSGSSTT-------------------G
RQGHGHY---QT---WD-------------SR-------------------GQGSSQSQA
----------GSTHG-QTGST-----H--------------------GQTT---------
-------------DSYGQQG---------------TSTTGSRDSS---PG-QYE--GEET
HYASSYGQTGTS-------------------------H----------------------
--GQTADSYGQT-----------GSRH--------------------------------R
QTGSS-----------NRQSGSSHG------Q-SRDS-----------------------
---------------------------------------YG-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------Q-TG----------------------------------------
-------------------------------------TSHG-------------------
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-------------

----------------MPRLLRDVLCVIETFHKYASEDSN-GATLTGRELKQLLQGEFGD
FFQPCV------------LHAVEKNSDLLNIDNNGIISFD-----------E-FVL-A--
-I---------------F-N-L-L-N-L-C-YLD----IQL-----LLS---S-ELRQ--
-VTKP-EKEKPDD------VDLQATT---GD---------GQWTAG---TSPT-------
-----------QEER----------------MLPS----------------------GMA
SLSQLIPEES----------------GAVGNNRVD-PWREAKTHNFPGEASEYNDP----
---KNQHL-------------------------------------------------EGD
-------EQIQEVAQDVQTTEDNEGQ-LKANK---PMARSKQTSSPTK-RKG-QDKKISR
EGD-EP----VREQSVS------KIRDHF---------------GEQEGNLE--------
--------------------------------------------PQNSPPEEETQRSSE-
-----------------DQ----------EVRTEK-E--K----------YSNTQEPPL-
------Q------------------EEDE-P-------------SSERA---DLP-----
EQAAARTLSQTQ---KSTDPEDV--CRT----FDTQEPGKDAD------------QTPAE
------------TTN--SGEPEDYGR---------------------TSEIQE-------
------------------------------------------------------------
------------------------------------------------------------
------------------KESETKDLPVQGGSRNG----SETPDMR--------DERKER
RGPETHETAGQ-KE--------------------RDR---------------------KT
QTLVL-------------ETQTQDGQY--QEFQGLS-------KSKDAKKDSET------
-----------------------------------------QYLSSEGGDQT-----HPE
L--------------E-------GT----A-VSGGEAEHTKEGTTEAFVNRKNAPAAART
LGARE----------STQD-----------------------------------------
--------------------------------------------LAPLEK-QSAGENSRA
TKTHDK--PVEEEDGYQ-----------------------------------GEDSESPF
TQNDEGSSETPSSLASEEDNSSSETG---------------E------------------
--------LPMQGDSK------------------SQGDPHGESV---------QGGHNNN
PDT---------------------------------------------------------
------------------------------------------------------------
---------------------------------------------QRQGTPDEKNRAQEA
V------VPAVR------------------------------------------------
-GEDVQLTDHQEQPSRGEHK-Y--------QGPG-----T-KGPGAAVEPSGHPEAQ---
---ESTAGD--KNRKSLEIEITGALDED--FTDQLSLMQLPGKGD---------------
-------------------HRNELKVQRPSSKEEKGRATEAQNTMLKSLDEDNSASH---
--KIQLETKE-------TVTS-EEEDESPQELAGEGGDQKSPAKK-EENSSVPWPSLEKQ
VQRDQEPCSMERGAIHSSPLYQYLQEKILQQTNITQE--------------------DHQ
K---------------------------------QVQIAQASGPE---------LCS---
-VSLTSETSDFSVFFNYSQALQ---------------PYTRGLPLDESPAGA---PSPQA
LEDKQDYPQRERLVPQREASTT----------------------------------K---
-----------------------------Q------------------------------
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-------------

----------------MPRLLRDVFCVIETFHKYASEDSN-GATLTGRELKQLLQGEFGD
FFQPCV------------LHAVEKNSDLLNIDNNGIISFD-----------E-FVL-A--
-I---------------F-N-L-L-N-L-C-YLD----IQL-----LLS---S-ELRQ--
-VTKP-EKEKPDD------VDLQATT---GD---------GQWTAG---TSPT-------
-----------QEER----------------MLPS----------------------GMA
SLSQLIPEES----------------GAVGNNRVD-PWREAKTHNFPGEASEYNDP----
---KNQHL-------------------------------------------------EGD
-------EQIQEVAQDVQTTEDNEGQ-LKANK---LMARSKQTSSPTK-RKG-QDKKISR
EGD-EP----VREQSVS------KIRDHF---------------GEQEGNLE--------
--------------------------------------------PQNSPPEEETQRPSE-
-----------------DQ----------EVRTEK-E--K----------YSNTQEPPL-
------Q------------------GEDE-P-------------SSERA---DLP-----
EQAAARTLSQTQ---KSTDPEDV--CRT----FDTQEPGKDAD------------QTPAE
------------TTN--SGEPEDYGR---------------------TSETQE-------
------------------------------------------------------------
------------------------------------------------------------
------------------KESETKDLPVQGGSRNG----SETPDMR--------DERKER
RGPETHETAGQ-KE--------------------RDR---------------------KT
QTLVL-------------ETQTQDGQY--QEFQGLS-------KSKDAKKDSET------
-----------------------------------------QYLSSEGGDQT-----HPE
L--------------E-------GT----A-VSGGEAEHTKEGTTEAFVNRKNAPAAART
LGARE----------STQD-----------------------------------------
--------------------------------------------LAPLEK-QSAGENSRA
TKTHDK--PVEEEDGYQ-----------------------------------GEDSESPF
TQNDEGSSETPSSLASEEDNSSSETG---------------E------------------
--------LPMQGDSK------------------SQGDPHGESV---------QGGHNNK
PDT---------------------------------------------------------
------------------------------------------------------------
---------------------------------------------QRQGTPGEKNRAQEA
V------VPAVR------------------------------------------------
-GEDVQLTDDQEQPSRGEHK-Y--------QGPG-----T-KGPGAVVEPSGHPEAQ---
---ESTAGD--KNRKSLEIEITGTLDED--FTDQLSLMQLPGKGD---------------
-------------------RRNELKVQSPSSKEEKGRATEAQNTMLKSLDEDNSASH---
--KIQLETKE-------TVTS-EEEDESPQELAGEGGDQKSPAKK-EDNSSVPWPSLEKQ
VQRDQEPCSVERGAIHSSPLYQYLQEKMLQQTNITQE--------------------DHQ
K---------------------------------QVQIAQASGPE---------LCN---
-VSLTSETSDFSVFFNYSQASQ---------------PYTRGLPLDESPAGA---PPPQA
LEDKQDDPQRERLVPQREASTT----------------------------------K---
-----------------------------Q------------------------------
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-------------

----------------MPQLLEDVLCVIETFRKYARVDGD-EATLTCRELKELLRGEFGD
ILQPPAT-----------TQATERNLNLPDIDSNGTISFD-----------E-FIL-A--
-I---------------F-N-L-L-K-V-C-CLD----IES-----LLN---S-EPRQ--
-VSKP-EE-IRDD------MDLQGTC---GT---------GQRTEG---TSST-------
-----------QDKV----------------VFPS----------------------EMA
FSTQLNPKEV----------------GAAGHDRVN-PQGDTTTHKLPGEASGHVDR----
---KNQHL-------------------------------------------------EGD
-------EQSQEGAQDVAAIGDSGAQ-LETKK---PTVGSAQISSPSR-RKK-QDQES-Q
EGG-KP----AREQAGT------KTREQF---------------GEQEGNLG--------
--------------------------------------------MQSSPPGETTQRPSE-
--------------D--QD----------AAGGEK-GAKG----------PSKTQEPPL-
------Q------------------GKDE-P-------------SSDHA---DPP-----
EQAAAQKPFQMQ---KSTDPEDD--SG---------------------------------
-----------------------------------------------TAETQVPPVQD--
------------------------------------------------------------
------------------------------------------------------------
----------------------TKDLPVQGDSRNF----SETLKVR--------VERKQV
RGPEVHETAGQ-KE--------------------NER---------------------KT
QPPAL-------------EDQTEDVKN--QELQESA-------KGKNAEEDSKT------
-----------------------------------------QKLSSEGRDQK-----YLE
I--------------E-------GG----I-SPGEEAGHDEEGTAEVPVSSKNVPEAEET
PGARE----------GTQE-----------------------------------------
--------------------------------------------LTRLEN-QSGGENKKV
TKIHNK--PVKEDDGHQ-----------------------------------REDPEPIV
TLTDERSFETPRSLTPEDGDSSSETS---------------G------------------
--------LSVQGDSQ------------------RQADPPRESV---------QGSPNNN
PDL---------------------------------------------------------
------------------------------------------------------------
---------------------------------------------QQQVAPGENNRVPEA
A------VLAAG------------------------------------------------
-AEDEQVSEEQEWPVGKEHR-S--------QGSG-----T-KSPGPAVEPSGPPEAQ---
---ESTVGD--ENRKSLETGPLGVLNAG--FTGQLSPRQLPAKKY---------------
-------------------RRQELKVQGSRTK-EEDGAPETQEVPVQRLDEYSSVPP---
--KTHLEMEE-------PAKWEEEEDESPQELAGE----QNLAKK-ERDPSVPKSDIEGR
MQRDRGLCSVARGAVRSTPLYEYMQQKIRQPTNRAQK--------------------EHQ
N---------------------------------QAQPASAPSPA---------LRGDQQ
GAPLTSEISDGPVSFSDSQALQ---------------QHTRELLPDESPAGAKQTAPPQA
SEHKQGHPQREE--PQREASTP----------------------------------K---
-----------------------------Q------------------------------
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-------------

----------------MPKLLQGIVTVIDVFYNYATEYGN-CDMLSKKEMKELLETEFRQ
ILKNPDD-----------PDTVDIIMQSLDRDHNHKVDFT-----------E-YLI-M--
-I---------------L-R-L-A-K-A-C-NKI----IGK---D-YCQ---A-------
SGSKQKDHSRQ----------HQEEQSEKETE--------NE-------E--------EE
ASSSYSSSSAG-ENDSYY---KSS-RGNKKYKSRK-----------------------P-
---R-------Q------G-KEQ-------------------------------------
----------------------------------------S--SEQSTKSNS-SDFKNNE
------------------------------------------------------------
-----D-------------------YEKDQ------------------------------
----------------------------------------HGS-GFSYSSSNSRS-----
----------------RS-----------RKDSGIPQHGS--ESRQ-SSTSSKQGCGECQ
SSGSGRYGSSSGQSSGCGSGQSTGYGEQGSGKSQSSSHRRGRS-------------TSR-
-----------------------------ESYGSQ-EHGSGSRESSGFSQRGSGHGQSSR
-------------GR-QSGSF-----S--------------------GQSAG--SQQHQ-
S-----G--SRHGSHSGQ------------------------------------------
--SPTSGQQGSH------------------------------------------------
--YGQSSSYGTH-----------NSGS--------------------------------S
QSSSQ--------R--THGSGSRQS------S-GLGE-----------------------
---------------------------------------YGSSSG---------------
-------QP-SN----TQRQGS---GQ---------------GVSSGSGRY---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------GASSGQS-
----SGCGSGQSTGYGE-QGSGKSQSS-------SHRRGRSTSRESS-TSQQYGS-----
-------G-------SGESSGFSQRG-----------SARGQSSHSGQH-G---------
S---FSGQS-----------A---------------------------------------
------------------GSQHH---G----------A------CCGQSSGYG-------
----------QN-EH-------GSGQSPTSGQQGSH-----YSQSSSYGTHNSGSSQSS-
RQ----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------TTH-----GS------------------
------------------GSGQSSG-----------------------------------
------------------------LGQYGST------T----------------------
------------------------G-----------------------------------
------------------------------------------------------------
-----------------------------------------QTS----------------
---------------SSKGQ----GSGQGVSSGSGRY-----------------------
-------GSSSGQSSGCG-----S----------------------GQSTGYGEQ-----
----------GSGKSQSSSHRRGRST-----------------SRES-----------Y-
GS----QEHGSGS------RESSGFSQRGSGH----G-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------QSSRGRQSG--------SFSG-QSAGS--QQHQS-----G
SRH--GSRSG------------QSPTSGQQGSHYGQSSSYGTHNS-GSSQSSSHQR----
---------------------------------------------THGSGSRQSSGLGEY
-GSSSGQ---------TSSSKGQGSEQGVSSGSGRYGASSGQSSGCGSGQSTGYGE-QGS
GKSQSSSHRRGRSTSRESSTSQQYGSGSGESSGFSQRGSARGQS-SHSGQHGSFSGQSAG
SQHHGSCCGQTSGYGQNE-YGSGQSPTSGQ--------Q--GSHYSQSSSYGT-------
------------------------------------------------------------
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-------------

----------------MAELLNSILNVTKVFQKYAQENGD-CASLCKKELKQLLYAEFGD
ILR RPND-----------PQ TVDNILNLLDQDRNGQVDFH-----------E-YLL-L--
-V---------------F-Q-L-A-E-A-C-HRK----LGN---D-SCE---N-------
RCCQ-PKRRQE-R-----NRDRQFPEN-TGK---QH----SQQHEWERQ-----------
-NSCQS-PSERQEKE---------------SH--------------------------YS
QSERQGQDS--HC-DQSEKQNT---------------------------DSFHGQPEGQN
QEFPYGQCKSQDRDFHHAQSRRQGEDSSSGQKMNH-------------KSSC--GQHKLL
R--NI-------N-------------ASNQCE------KP------AQ-----------D
SHYGQL-----------------KRLGQQS------------SHFG-SFR----------
--------PDASSCQTN----------Q-----WDS------------------------
------------------------------------------------------------
-----------------------------------------------------GSRRLGK
EADSYQRHKQG---LDSQHDQTDNQG-Q--S------S-----------HYSQTDTQRQS
-------------------T--CHG-------------------------------RT--
---DT----QGHNAHHSQTDTQG--------------------------------HSTHH
GQKDI------------RRQ----------------------------------------
-----SARHGQ-------------------------------TDTRGHREAQ-T--RHSS
EEQS--HQTVKEQG---HPSRSTHSHERHENPHRCT----PEALKNYNC---Q---RGHQ
QVH------KDAQRHQRQDWQG-------FEFRHYQRNRQTRVDHHNHQKK---------
------------------------------------------------------------
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-------------

----------------MPQLLRNINGIIEAFRRYARTEGD-CAVLERGELKRLLEKEFAD
VIVKPHD-----------PATVDEVLRLLDEDDTGTVEFK-----------E-FLV-L--
-V---------------F-K-V-A-Q-A-C-FET----LSEGP-EGACG---S-----QE
SGRV-----AP-A----ATQEPGA-GQRGSTAV--GRPGNRQGPAG--------------
-------SS-------------------------------------------------DT
QSEQA-----------SGGLGG---------------PVPQTQG----------------
------------------------QDISSA----QDR------------------QSASQ
RQEGV-SQSTQARGHVEQAQRTREDKSPQTRE------R--------------G-----T
ERQP-----QARDQDRAHQTSEAV-PGTI-------------------------------
--------------------------------------------TQTQT--SASQAVEQD
RSQQSGSASTQPRESTR----GT----------------E--------------------
-----AHSQDGRQTSQ-----VVTGGHIQTQ-------------TRSHTQTHTHTTEQDR
SQQTGSASTQPR---EPTRGT----E-----------------------------TH---
-SQ---------------TSQVVTGG----------------------------------
-------HIQTQTRSHT----QT--------------VEQNRSH--------------QT
GSA----STQPREPTRGTET----------------------------HSQDGRQTSQVV
TGGHVQ------------------------------------------------------
------------------------------------------------------------
----THTHTTEQDRSQ----------------QTGSASTQPREPTCGQARGTETHSQDRY
Q---------------TRQVVT---GG--HI----------QTQPGGH------------
-----------------------------------------I------------------
------------------------------------------------------------
----------------------QTQGGITSHPGAGE------------------------
---------------------------------------------------QGQPQ----
RQPGSSQRQTQVSNCEA-GE----------------------------------------
---------TVLG-------------------------GQAQ----TVTGRQDRSSTQPP
RSA----------TGAQG-----------------------AREPT--------------
-------VVHQEWVDDHTRET---VIRRQDEGS----LHA--------------------
------------------GVPSAQGREAAQ------------PE-GKRGLT-ARG-----
----------L--------------------------YSYFKSSKP--------------
------------------------------------------------------------
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-------------

----------------MPQLLRNIHGIIEAFGCYARSEGG-CKVLTKQELKRLLEYEFAD
VIVKPHD-----------PATVDEVLHLLDEDNTGTVEFK-----------E-FLV-L--
-V---------------F-K-V-A-R-A-C-FKT----LNESP-KGACM---S-----DK
SESC-----HV-G----SSKELEQ-GQRGGAEV--AKDGAAQHCEN--------------
-------SS-------------------------------------------------CG
QRDQA-----------SRGQDR---------------VGTHTQH----------------
------------------------QDSYPTWVSSHDR------------------QAESQ
TQEMI-SQQTQVTGPVEQTPKIEDKSC--IGQ------K--------------R-----S
ERQP-----QISQQ-----TDEIT-TEST-------------------------------
--------------------------------------------TQTQA--G--------
--------TFYTQGSTCDQNRGT----------------N--------------------
-----SLTQDRSQTDQ------ASTQHYQTR-------------AGSHTQIHNQTVEQGW
GQQTGKNNIQIQ---GSIYDQSRETE-----------------------------IRGQD
RNQ---------------ASQTAKE-----------------------------------
-------HHQAQAESY--------------------------------------------
------------------------------------------------------------
------------T-----------------------------------------------
------------------------------------------------------------
---RAHTQTMEQGRSQ----------------QEENGSIQTHASICGQNRGTKIHEQESN
Q---------------VEQVGT----G--HC----------QTQAGSDAQTL--------
-----------------------------------------E------------------
------------------------------------------------------------
----------------------HNGSHSARQVVAQE------------------------
---------------------------------------------------KGQMQ----
TQSCMGQSWTPVSNYET-GE----------------------------------------
---------PVLG-------------------------Q-VQTEIDTVKERQPWNSNHP-
-SL----------AGRQG-----------------------ERSPT--------------
-------VVREEWVNDHTREI---VIRSQDPGS----LHS--------------------
------------------GAPSAQGQDTAQ------------M--EKKGIT-AKG-----
----------L--------------------------YSYLKTEQP--------------
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-------------

----------------MPQLLRDVLCVIETFHKYASEDSN-GATLTGRELKQLLQGEFGD
FFQPCV------------LHAVEKNSNLLNIDNNGIISFD-----------E-FVL-A--
-I---------------F-N-L-L-N-L-C-YLD----IQL-----LLS---S-ELRQ--
-VTKP-EKEKPDD------VDLQATT---RD---------GQWTAG---TSPT-------
-----------QEER----------------MLPS----------------------GMA
SLSQLIPEES----------------GAVGNNRVD-PWREAKTHNFPGEASEYNDP----
---KNQHL-------------------------------------------------EGD
-------EQIQEVAQDVQTTEDNEGQ-LKANK---PMARSKQTSSPTK-RKG-QDKKISQ
EGD-EP----VREQSVS------KIRDHF---------------GEQEGNLE--------
--------------------------------------------PQNSPPEEETQRPSE-
-----------------DQ----------EVRTEK-E--K----------YSNTQEPPL-
------Q------------------GEDE-P-------------SSERA---DLP-----
EQAAARTLSQTQ---KSTDPEDV--CRT----FDTQDPGKDAD------------QTPAE
------------TTN--SGEPEDYGR---------------------TSETQE-------
------------------------------------------------------------
------------------------------------------------------------
------------------KESETKDLPVQGGSRNG----SETPDMR--------DERKER
RGPETHETAGQ-KE--------------------RDR---------------------KT
QPLVL-------------ETQTQDGQY--QEFQGLS-------KSKDAKKDSET------
-----------------------------------------QYLSSEGGDQT-----HPE
L--------------E-------GT----A-VSGGEAEHTKEGTTEAFVNRKNAPAAART
LGARE----------STQD-----------------------------------------
--------------------------------------------LAPLEK-QSAGENSRA
TKTHDK--PVEEEDGYQ-----------------------------------GEDSESPF
TQNDEGSSETPSSLASEEDNSSSETG---------------E------------------
--------LPMQGDSK------------------SQGDPHGESV---------QGGHNNN
PDT---------------------------------------------------------
------------------------------------------------------------
---------------------------------------------QRQGTPGEKNRAQEA
V------VPAVR------------------------------------------------
-GEDVQLTDDQEQPSRGEHK-Y--------QGPG-----T-KGPGAAVEPSGHPEAQ---
---ESTAGD--KNRKSLEIEITGALDED--FTDQLSLMQLPGKED---------------
-------------------SRNELKVQGPSSKEEKGRATEAQNTMLKSLDEDNSASH---
--KIQLETKE-------TVTS-EEEDESPQELAGEGGDQKSPAKK-EDNSSVPWPSLEKQ
VQRDQEPCSVERGAIHSSPLYQYLQEKILQQTNITQE--------------------DHQ
K---------------------------------QVQIAQASGPE---------LCS---
-VSLTSETSDFSVFFNYSQASQ---------------PYTRGLPFDESPAGA---PSPQA
LEDKQDYPQRERLVPQREASTT----------------------------------K---
-----------------------------Q------------------------------
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-------------

----------------MPKLLQGVITVIDVFYQYATQHGE-YDTLNKAELKELLENEFHQ
ILKNPND-----------PDTVDIILQSLDRDHNKKVDFT-----------E-YLL-M--
-I---------------F-K-L-V-Q-A-R-NKI----IGK---D-YCQ---V-------
SGSKLRDDTHQ----------HQEEQEETEKE--------E---------NKR-----QE
SSFSHSSWSAG-ENDSYS---RNV-RG---------------------------------
------------------------------------------------------------
----------------------------------------S--LKPGTESIS-RRL----
----------------------------------------------------SF------
---QRD-------------------FSGQH------------------------------
----------------------------------------NSY-SGQSSSYGEQNSDSH-
---------------------------------------------------------Q--
--------SSGRGQCGSGSGQSPNYGQHGSGSGQS-------------------------
---------------------------------------------SSNDTHGSGSGQSSG
-------------FS-QHKSS-----S--------------------GQSSG--YSQHG-
S-----G--SGHSSGYGQH----------------GSRSGQSSRGER-------------
--------HRSS------------------------------------------------
--SGSSSSYGQH-----------GSGS--------------------------------R
QSLGH--------G--RQGSGSRQS------P----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------SHVRHGS-----
-------G-------SGHSSSHGQHG-----------SGSSYSYSRGHY-E---------
S---GSGQT-----------S---------------------------------------
------------------GFGQH---E----------S------GSGQSSGYS-------
----------KH-GS-------GSGHSSS----------------QGQHGSTSG------
------------------------------------------------------------
------------------------------------------------------QA----
----SSSGQ---------------------------------------------------
------------------------------------------------------------
----------------------------------H-----GS------------------
------------------SS---RQ-----------------------------------
------------------------SSSYGQH-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------ESASRHSSGRGQH-----------------------
-------SSGSGQSPGHGQRGSGS----------------------GQSPSSGQH-----
----------GTGFGRSSSSGPYVSG-----------------SGYS---------SGF-
GHH--ES-SS---------EHSSGYTQHGSGS----G-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--HSSGH---GQHG-----S----------------------------------------
-----------------RSGQSSRGERQG--------SSAG-SSSSY--GQHGS------
-------GSR------------QSLGHSRHGSGSG------------QSPSPSRGR----
---------------------------------------------H-ESGSRQSSSYGPH
-GYGSGR---------SSSRGPYESGSGHSSGLGHQESRSGQSS--------GYG-----
----------QH------------GSSSGHSSTHGQHGSTSGQS-SSCGQHGATSGQSSS
HGQHGSGSSQSSRYGQQG-SGSGQSPSRG-----------------------RH------
GSDF-GHS----------------SSYGQ---HGSGS------------------G----
----------WSSSNGPHGSV---------SGQSS-------------------------
--GFGH-----------K------------------------------------------
----------------S----GSGQS----------------------------------
------------------------------------------------------------
----------S-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---GYSQ-----------HGSGSSHSSGYRK-----------------------------
-------HGSR-SG--Q-----------------------------------SSRSE-QH
--G-SSSGLSSSYGQHGSGSHQSSGHGRQG-SGSG--------HSP-SRVRHGSS--SGH
SSSHGQHGSGTSCSSS-----------C-GHYESGSGQASGFGQHESGSG--QGYSQHGS
ASGHFSSQG--------------RHGSTSGQSSSSGQHDSSSGQSSSYGQHESASH----
------------------HASGRGRHGSGSGQS---------PGHGQRGSGSGQSPSYGR
HGSG--------------------------------------------------------
---------------------------SGRSSS-SGRHGSGSGQSSGFGHKS-SSGQS--
--SGYTQHGS--------------------------------------------------
------------------------------------------------------------
----------GSGH--SSSYEQHGSRSGQ-------------------------------
------------------------SSRSEQHGSSSGSSSSYGQHGSGSRQSLGHGQHGSG
SGQSPSPSRGRHGS----------------------------------------------
-------------------------------------------GSGQSSSYGPYRSGSGW
S-----S-----------------------------------------------------
-----------------SRGPY--ES----------------------------------
------------------------------------------------------------
------GSGHS------------------------------------------SGLGHRE
SRSGQS-SGYGQHGSSSG--HSSTHGQHGSTSGQS-SSCGQHGASSGQSSSHGQ------
--------------------------H-----------------GSGS--SQSSGYGRQG
SGSGQSPGHG--------------------------------------------------
-----------------------------QRGSGSRQSPSYGRH----------------
------------------------------------------------------------
----------------------------GSGSGRSS-------SSGQHGSGLGESSGF--
-GHH----------------------------------------------ESSSGQSSSY
SQHG--------------------------------------SGSGHSSG----------
----------------------------YGQHGS-RSGQSS----RGERHGSSSG-----
-------------------SSSHYG--------------QHGSG----------------
----------------SRQSSGHGR-----------------------QGSGSGHSPSRG
R-HGSGLGHSSSHGQHGSGSGR--------------------------------------
----S-----S-------------------------------------------------
SRGPYESR----------------------------------------------------
-----------------------------------SGHSSVFGQHES-GSGHSSAYSQH-
----GSGSGHFCSQGQHGSTSGQSSTFDQEGSSTGQSSSYGHRGSGSSQSSGYGR-----
--------H-GAGSGQSP----------------SR------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---GRHGSGSGHSS-----------SYGQHGSGSGWS-----------------------
-----------S-SS-------G-------------------------------------
------------------------------------------------------------
-RHGSGSGQ--------------SSGF------------------------GHHESSSWQ
--SSGCTQHGS------GSGHSSSYEQH--------------------------------
-------------GSRSGQ-SSRGERHGSSSGSSSSY---GQHGSGSRQSLGHGQHGSGS
GQSPSPSRGRHGSGSGQSSS---------YSPYGSGSGWSSSRGPYESGS----------
-----------SHSSGLGHRESRSGQSSGYGQH---------------------------
------------------------------------------------------------
----------------------GSSSGHSSTHGQHGSTSGQSSSCGQHGASSGQ-SSSHG
QHGSGSSQ--SSGYGRQGS--GSGQSPG---HGQR---G--------------SGSRQSP
SYGRHGSGSGRSSSSGQHGSGLGESSG--FGH---------HESSSGQSS----------
-----------------------SYSQHGS--------G-SGHSSGYGQHGSRSGQSSRG
ERHGSSSR-------------------------------------------------SSS
-------------------R----------YGQHGS-GSRQSSG----------------
----------HGRQGSGSGQSP-----------------SRGRHGS--GLGHSSSHGQH-
-GSGSGRSSSRGP-YESR------SGHS--------------------------------
------------------------------------------------------------
------------------SVFGQHESGSGHSSAYSQHGSGSGHFCSQ-----------GQ
HGSTSGQSSTFDQE------------------------------------GSSTGQSSSH
GQHGSGSSQSSSYGQQGSGSGQS------PSR---GRHGSGSGHSSSYGQHGSGSGWSSS
SGRHGSGSGQSSGFGHHESSSWQSSGYT---QHGSG--SGHSSSYEQHGSRSGQSSRGEQ
HGSSSGSSSSYGQHGSGSRQSLGHGQHGSGSGQSPSPSRGRHGSGSGQSSSYGPYGSGS-
-------GWS-----SSRGPYESGSGHSSGLGHRESRSGQSSGYGQHGSSSG--------
-----------------------------H------------------------------
----SSTHGQHGSASGQSSSCGQH-GASSGQSSSHGQHGSGSSQSSGYGRQ---------
----------------------------------GSGSG---------------------
------------------------------------------------------------
--------QSPGHGQRGSGSRQSPSYGRHGSGS-----------------GRSSSSGQHG
PGLGE-----------------SSGFGHHESSSGQSSSYSQH------------------
--GSGS-------GHS------SGY------GQHGSRSGQSSRGERHGSSSG--------
SSSRYGQHGSGSRQSSGHGRQGSGSGHS----PSRGRHGSGSGHSSSHGQHGSGSGRSSS
RG-PYESRSGHSSVFGQHESGS--GHSSAYS-----------------------------
----------QHGSGSGHFCSQGQHGSTSGQSSTFDQEGSSTGQSSSHGQHGSG------
--------------------SSQSSSYGQQGSG-------------SGQSPSRGRHGSGS
GHSSSYGQHGSGSGWSSSSGRHGSGSGQSSGFGHHESSSWQSSGYTQHGS-GSGHSSSYE
QHGSRSGQSSRGERHGSS---------------------SGSSSSYGQHGSGSRQSLGHG
QHGSGSGQSPSPSRGRHGSGSGQSSSYSPYGSGSGWSSSRGPYESGSG---HSSGLGHRE
SRSGQSSGYGQH------GSSSGHSSTHGQHGSTS--GQSSSCGQHGASSGQS-SSHGQH
GSGSSQSSGYGRQGSGSGQS--PG-------------------HGQRGSGSRQSPSYGRH
GSGSGRSSSSGQHGS---GLGESSGFGHHESSSGQSSSYSQHGSGS--------------
--------------------GHSSGYGQHGSRSGQSSRGERHGSSSG------SSSHYGQ
HGSGSR--QSSGHGRQGSG----SGQSPSRGRHGSG--LGHSSSHGQHGSGSGRSSSRGP
YESRLGHSSVFGQHESGSGHSSAYSQHGSG----SGHFCSQ--------------GQHGS
TSGQ--------------------------SSTFDQEGSSTGQSSSY-------------
G-------------HRGS-------------------GSSQSSGYGRHGAGSGQSLSHGR
HGSGSGQSSS--------------------------------------------------
------------------------------------------------------YG-QHG
S-GSGQSS-GYSQHGSGSGQDGYSYC-KGGSNHD----GGSSGSYFLSFPSSTSPYEYVQ
EQRCYFYQ----------------------------------------------------
------------------------------------------------------------
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-------------

----------------MPQLLQNIHGIIEAFGCYARSEGD-CKVLTRGELKRLLEHELAD
VIVNPHD-----------PSTVDEVLRLLDEDNTGTVEFK-----------E-FLV-L--
-V---------------F-K-V-A-R-A-C-FKT----LSESS-RGACM---S-----DM
SECC-----SP-G----SSKELEQ-GQRGGTGG--GRDGAEQCFED--------------
-------SS-------------------------------------------------SG
QRDQV-----------SKKQVR---------------VGTHTQS----------------
------------------------QDSYPTQGSSHDR------------------ELESQ
RQEM-VSQQTQVTGQVAQTPRREDKTW--TRE------R--------------R-----S
EMPS-----QISQQ-----TEEAA-AGPT-------------------------------
--------------------------------------------TQTQG--G--------
--------Q---DRGT-----------------------N--------------------
-----SHSQDRSQADQ------AATQHYQTQ-------------TGSHTQIHTQTVEQGW
RQQTGSDRIQTQ---GSIYE-----------------------------------TQGQD
RNQ---------------AGQAAEE-----------------------------------
-------HQQEK------------------------------------------------
------------------------------------------------------------
------------S-----------------------------------------------
------------------------------------------------------------
---YTHTQTTEQSRSQ----------------QAENSSIQTPGSIYDQNRRTEIHGQDSS
H---------------AEQVGA----G--HF----------QT------QTL--------
-----------------------------------------E------------------
------------------------------------------------------------
----------------------HDRNQSAGRVGAPE------------------------
---------------------------------------------------KGQAQ----
IQSGIVQSCIPESNYET-EE----------------------------------------
---------PGLG-------------------------GQVQSKTS------TVKENHP-
-SP----------KGGQG-----------------------QRVPT--------------
-------VIRDEWVNDHTREI---VIRSQDPGS----LHS--------------------
------------------RAPSAQGQDAAR------------ME-EKKGIE-AKG-----
----------Q--------------------------YSYLKTDQP--------------
------------------------------------------------------------
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-------------

------------------------------------------------------------
---NPHD-----------PGTVDEVMRLLDEDETGTVEFK-----------E-FLV-L--
-T---------------F-K-V-A-Q-A-C-FQA----LSESP-EGACG---S-----QE
SGRH-----RT-G----ASQELRE-GQRRPTEV--GGAGASQLPEG--------------
-------GS-------------------------------------------------GG
QSPQM-----------SRGQDQ--------LH----------------------------
--------------------------------AVTGR------------------QTESQ
RQENP-SQRQ-EQGQVR-QTRIPEERHHQTRE------G--------------R-----S
DREP-----QTRKQDGAHHSRETV-TGTQ-------------------------------
--------------------------------------------TQTV-----THTTEQD
RGHQRGNTSTHSWESTSGQTRGS----------------Q--------------------
-------GQDMSQTRQ-----TVTGGHLQTQ-------------TG--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----SHGHTTEQDRGH----------------QRGNTSTHPWESTSGQTRVT--QSQDRN
Q---------------SSQTVT---GG--HR----------QTQTGSQTQ-V--------
-----------------------------------------E------------------
------------------------------------------------------------
----------------------QERSQMGSHAGAGE------------------------
---------------------------------------------------EGQSQ----
SLSGSGQRGAHVSNPEA-GA----------------------------------------
---------TTLG-------------------------GQAQPGGSPLPGSHSCRHGDPR
CSE----------TERQG-----------------------EGEPH-A------------
---TGPSEIHEEWVDDPTMEI--------GQKS----PHT--------------------
------------------SVSSAQGGEAAQ------------PE-GRQGIT-GGG-----
----------R--------------------------SSYFQSNAP--------------
------------------------------------------------------------
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-------------

---------------KMPQLLKNIGGIIDSFKRYARLEGD-CTVLTRGELKRLLETEFSD
VIV RPHD-----------PV TVNEILRLLDEDKSGTVDFK-----------E-FLV-L--
-T---------------F-K-V-A-Q-A-C-YET----LSKIP-EGTCG---L-----QT
------------------SQELGD-GQRSGAGT--GRAEEGQWQEG--------------
-------SL-------------------------------------------------HG
QAPM--------------GQGR--------AV-------IENQG----------------
---------------------------QATQLSGYDE------------------LPESQ
RQ-KE-IQKTQARGDGDQTHRPEGEQSHQTGE------N--------------P-----S
KKQT-----QSSQQDRVWE-GARV-TAKG-------------------------------
--------------------------------------------TQAQE--GVTQAGEQD
RSSHTGSTDTQSQEPMNGQTTGT----------------V--------------------
-----AHDQEKSQTSQ-----VVAGGHSQTQ-------------IGSHTQT---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--QVDANQTVEQGRSH----------------QTGSTGTQSQGPMSGQTSGNVTQSQDRT
Q---------------TSQVVT---GG--HN----------QTQTGSHTQAV--------
-----------------------------------------E------------------
------------------------------------------------------------
----------------------QGWTQTTGHERTEL------------------------
---------------------------------------------------EGWTQ----
TQSRSGPRWAHVSNFEA-GE----------------------------------------
---------TVPR-------------------------VQTQTGAGPGTGRQAESK----
--------------------------------------------T---------------
------TTTQQEWTDDHSSET---VSQK--------------------------------
-----------------------QGQETVQ------------KE-GKPGMT-ASG-----
----------L--------------------------YSYLKSTNP--------------
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-------------

----------------MPQLLRNVLCVIETFHKYASEDSN-GATLTGRELKQLIQGEFGD
FFQPCV------------LHAVEKNSNLLNIDSNGIISFD-----------E-FVL-T--
-I---------------F-N-L-L-N-L-C-YLD----IKS-----LLS---S-ELRQ--
-VTKP-EKEKLDD------VDLQATT---GD---------GQWTVG---TSPT-------
-----------QEER----------------MLPS----------------------GMT
SSSQLIPEES----------------GAVGNNRVD-PWREAKTHNFPGEASEHNDP----
---KNKHL-------------------------------------------------EGD
-------EQSQEVAQDIQTTEDNEGQ-LKTNK---PMAGSKKTSSPTE-RKG-QDKEISQ
EGD-EP----AREQSVS------KIRDQF---------------GEQKGNLA--------
--------------------------------------------TQSSPPKEATQRPSE-
-----------------DQ----------EVRTEK-E--K----------HSNIQEPPL-
------Q------------------REDE-P-------------SSQHA---DLP-----
EQAAARTPSQTQ---KSTDPKDV--CRM----FDTQEPGKDAD------------QTPAK
------------TKN--LGEPEDYGR---------------------TSETQE-------
------------------------------------------------------------
------------------------------------------------------------
------------------KECETKDLPVQYGSRNG----SETSDMR--------DERKER
RGPEAHGTAGQ-KE--------------------RDR---------------------KT
RPPVL-------------ETQTHDGKY--QELQGLS-------KSKDAEKGSET------
-----------------------------------------QYLSSEGGDQT-----HPE
L--------------E-------GT----A-VSGEEAEHTKEGTAKAFVNSKNAPAAERT
LGAKE----------RTQD-----------------------------------------
--------------------------------------------LAPLEK-QSVGENTRV
TKTHDK--PVEEEDGYQ-----------------------------------GEDPESPF
IQSDEGSSETPNSLASEEGNSSSETG---------------E------------------
--------LPVQGDSQ------------------SQGDQHGESV---------QGGHNNN
PDT---------------------------------------------------------
------------------------------------------------------------
---------------------------------------------QRQGTPGEKNRALEA
M------VPAVR------------------------------------------------
-GEDVQLTEDQEQPAGGEHK-N--------QGPG-----T-KGPGVAVEPNGHPEEQ---
---ESTAGD--ENRKSLEIEITGALDED--FTDQLSLMQLPGKGD---------------
-------------------GRNELKVPGPSSKEEKGRATEAQNTLLKSLDEDNSASL---
--KIQLETKE-------PVTS-EEEGESPQKLAGEGGDHKSPAKK-EHNCSVPWPSLEKQ
MQRDKEPCSVERGAVHSSPLYQYLQEKILQQTNVTQE--------------------EHQ
K---------------------------------QVQIAQASGPE---------LCS---
-VSLTSEISDCSVFFNYSQASQ---------------PYTRGLPLDESPAGAQETPAPQA
LEHKQGHPQRERLVPQREASTT----------------------------------K---
-----------------------------Q------------------------------
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-------------

----------------MPQLLQNINGIIEAFRRYTRTEGN-CTALTRGELKRLLEQEFAD
VIVKPHD-----------PATVDEVLRLLDEDHTGTVEFK-----------E-FLV-L--
-V---------------F-K-V-A-Q-A-C-FKT----LSESP-EGACG---S-----HE
SGSL-----HS-G----ASQELGE-GQRSGTEV--GRAGKGQHYEG--------------
-------SS-------------------------------------------------HR
QSQQG-----------SRGQNR---------------PGVQTQG----------------
------------------------QATGSAWVSSYDR------------------QAESQ
NQERI-SPQIQLSGQTEQTQKAGEGKRNQTTE------M--------------R-----P
ERQP-----QTREQDRAHQTGEIV-TGSG-------------------------------
--------------------------------------------TQTQA--GATQTVEQD
SSHQTGRTSTQTQEATNDQNRGT----------------E--------------------
-----IHSQGRSQTSQ-----AVTGGHAQIQ-------------AG--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------THT-----------------------------------------------
------------------------------------------------------------
---QTPTQTVEQDSSH----------------QTGSTSTQTQESINSQNRGTEIHGQGRS
Q---------------TSQAVT---GG--HT----------QTQAGSHTQTV--------
-----------------------------------------E------------------
------------------------------------------------------------
----------------------QDRSQTVSHGGARE------------------------
---------------------------------------------------QGQTQ----
TQPGSGQRWMQVSNPEA-GE----------------------------------------
---------TVPG-------------------------GQAQTRASTESGRQEWSSTHPR
RCV----------TEGQG-----------------------DRQPT--------------
-------VVGEEWVDDHSRET---VILRLYQGN----LHT--------------------
------------------SVSSAQGQDAAQ------------SE-EKRGIT-ARE-----
----------L--------------------------YSYLRSNKP--------------
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-------------

----------------MPQLLRNVLCVIETFHKYASEDSN-GATLTGRELKQLIQGEFGD
FFQPCV------------LHAVEKNSNLLNIDSNGIISFD-----------E-FVL-A--
-I---------------F-N-L-L-N-L-C-YLD----IKS-----LLS---S-ELRQ--
-VTKP-EKEKLDD------VDVQATT---GD---------GQWTVG---TSPT-------
-----------QEER----------------MLPS----------------------GMA
SSSQLIPEES----------------GAVGNNRVD-PWREAKTHNFPGEASEHNDP----
---KNKHL-------------------------------------------------EGD
-------EQSQEVAQDIQTTEDNEGQ-LKTNK---PMAGSKKTSSPTE-RKG-QDKEISQ
EGG-EP----AREQSVS------KIRDQF---------------GEQEGNLA--------
--------------------------------------------TQSSPPKEATQRPSE-
-----------------DQ----------EVRTEK-E--K----------HSNIQESPL-
------Q------------------REDE-P-------------SSQHA---DLP-----
EQAAARTPSQTQ---KSTDSKDV--CRM----FDTQEPGKDAD------------QTPAK
------------TKN--LGEPEDYGR---------------------TSETQE-------
------------------------------------------------------------
------------------------------------------------------------
------------------KECETKDLPVQYGSRNG----SETSDMR--------DERKER
RGPEAHGTAGQ-KE--------------------RDR---------------------KT
QPLVL-------------ETQTQDGKY--QELQGLS-------KSKDAEKGSET------
-----------------------------------------QYLSSEGGDQT-----HPE
L--------------E-------GT----A-VSGEEAEHTKEGTAEALVNSKNAPAAERT
LGARE----------RTQD-----------------------------------------
--------------------------------------------LAPLKK-QSVGENTRV
TKTHDK--PVEEEDGYQ-----------------------------------GEDPESPF
TQSDEGSSETPNSLASEEGNSSSETG---------------E------------------
--------LPVQGDSQ------------------SQGDQHGESV---------QGGHNNN
PDT---------------------------------------------------------
------------------------------------------------------------
---------------------------------------------QRQGTPGEKNRALEA
V------VPAVR------------------------------------------------
-GEDVQLTEDQEQPARGEHK-N--------QGPG-----T-KGPGAAVEPNGHPEAQ---
---ESTAGD--ENRKSLEIEITGALDED--FTDQLSLMQLPGKGD---------------
-------------------SRNELKVQGPSSKEEKGRATEAQNTLLESLDEDNSASL---
--KIQLETKE-------PVTS-EEEDESPQELAGEGGDQKTPAKK-EHNSSVPWPSLEKQ
MQRDQEPCSVERGAVHSSPLYQYLQEKILQQTNVTQE--------------------EHQ
K---------------------------------QVQIAQASGPE---------LCS---
-VSLTSEISDCSVFFNYSQASQ---------------PYTRGLPLDESPAGAQETPASQA
LEDKQGHPQRERLVPQREASTT----------------------------------K---
-----------------------------Q------------------------------
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-------------

----------------MSTILENIISIIDLFHQYSTRDKE-TETLSKKELKELLEIEFQS
ILKNPHD-----------PDTADVFMHILDIDRNKKIDFT-----------E-FFL-M--
-V---------------F-K-L-A-Q-A-Y-YES----TRR---H-NFQ---E-------
SRQKQKKDGHH----------NKHEEDDTEEE--------ER-------KRTS-----SH
S------RSDG-KRK-KA--QSNSSRGRGEHTHVS-----------------------T-
-SGRQGQEG------------------------ERSTSRHQKEHG-KTHHES--------
----------------------------------------S--GKKKRRSSSTEEHERRH
E--------------------------ATLG-------------SERR----NE-----G
REDKHG-------------------YENER------------------------------
------------------------------------------RESAEWKL-GSEGLQ---
--------------------------------------------------------HAC-
------------------------------------------------------------
----GEN---IW---KNTNIQVEENE---------------EKRNSGTAHGQASSGA---
-----------------------AGS----------------------RRRGSSPSQGT-
AGSRRRG--SSPSQ----------------------------------------------
------------------------------------------------------------
-----------------------GSESE-GHSEDSER-----------------------
----------------PSASGSG------------HQ-----------------------
---------------------------------------HGSA-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------FGH-AGDSARHSASQ-------------------------------
--RGRSARHGHHGQSPD---SSGRSG-----------SHHAEASSRGHTDS---------
AR----------------------------------------------------------
--------------------------------------------GQSRSSTRG-------
----------RQ-ES-------RPE-----------------------------------
-----------------HSADSSRH-S-----G---------AAHGRPS-----------
------------------------------------------------------------
-SGSRPAGQ--RA---------------------SSASQASDSEGHSEASGTQSRST---
-------------------------------HGRS-------------------------
---------------------------ASGSRNQH-----GS------------------
------------------THGQSGD-----------------------------------
----------------------------------------SAR-----------------
--------------------HS----------------GSHQG-----------------
-------QAA-SHRHSD-------------------------------------------
------------------------------------------------------------
-------------------------------SAHGHS-----------------------
-------GSSTRETQGRRHEQS-AD-SSRHS-----------------GTAHGQASRRGS
SPNS--------------------------------------------------------
----------------------GAAGRHGSSH----GQSP---------DSSGRSGSHHA
E-----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------ASSRGHTDS------ARGQSRSSTRGRQESRPE----
-H--S----ADSSRHSGAAH--------------GRPSSGSADSSRHS------------
----------------GTAHGQASSGA---AGSRRRGSSPSQGSE--------SE-----
----------------G HSEDS------------------------------------ER
PSASGSGH-------------------------------------HHGSAFGHA------
GDSARHSASQ--------------------------R------------------G----
----------RSARHGHHGQS---PD---SSGRSGSH-----------------------
-HAEAS-------------------------------S----------------------
-----RGH------TDS----ARG QS--RS------------------------------
----------------------------STRGR---------------QE----------
---------------SRPEHS---------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------ADS-S
RHSGAAH-----------GRPSSGSRP-AGQRASSASQASDSEGHSEASGTQSRSTHGRS
ASGSRNQHGST-HG--QSGDSAR-----------------------------H--SGSHQ
GQAASHRHSDSAHGHSGSSTRE--------------------------------------
--TQGRRHEQSADSSRHSGTAHGQA----S--RRGS------------SPNSGAAGRHGS
SHGQSPDSS-----G---------------------RSGSHHAEASSRGHTDSARGQ---
-----------------SRSSTRGRQESRPEHS----------------ADS--------
------------------------------------------------------------
-------------SRHSGAAHGRPSSGQSAD------S---------SRHSGTAHGQAS-
---------------------------------------SGA-AGSRRRGSSPSQGSESE
G HSEDSERPSASGSGHHHGSAFGHAGDSARHSASQRGRSARHGHHGQSPDSSGRSGSHHA
EASSRGHTDSARG QSRSSTRGRQESRPEHS-----------------------ADSSRHS
GAAHGR-PSSGSRPAGQRASSASQASDSEGHSEASGT---------QSR---------ST
HGRSASGSRNQHGSTHGQSGDSARHSGSHQGQAASH------------------------
---------RHSDSAHGHSGSSTRETQGRRHEQSADSSRHSGTAHGQASRRGSSPN----
------------------------------------------------------------
------------------------------------------------------------
--------S--GAAGRHGSSHGQSPDSSGR----SGS----------------------H
HAEAS-------------------------------------------------------
------------------------------------------------------------
---------------------------------------SRGHTDSARGQS---------
------------------------------------------------------------
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-------------

----------------MPQLLRDILCVIETFHKYAREDGG-VATLTCTELKQLIQSEFED
ILQPCA------------THAVESNLNLLNIDSNGAISFD-----------E-FVL-A--
-I---------------F-S-F-L-N-F-C-YLD----IQS-----LLN---S-E-----
----P-EG-MPHG------MGLQVMN---GT---------DQGTEG---TSQT-------
-----------QDKV----------------VLPS----------------------GTA
SSTHLSLKEE----------------RAVEHNRVD-PQGHTTAHKLPVETSEHSDS----
---KNQHL-------------------------------------------------KGD
-------EQSQKVAQDVSATGDSRTQ-PETSK---PMAGSEQISSRTK-VEG-QNKESLQ
KGD-TL----ARKQSGT------ETGEWF---------------GEQEGSLG--------
--------------------------------------------TLHSPLGETTQRPGG-
--------------SSEDQ----------EAAGEK-GAKE----------HPKAQEPSV-
------Q------------------GKDE-P-------------SSDHV---DLP-----
KQAAARKPSQTQ---KSAAPEDD---R---------------------------------
-----------------------------------------------TAETPEPPIQK--
------------------------------------------------------------
------------------------------------------------------------
------------------KEYETRDLSVQGDNRNV----PETPTVR--------VERKDV
RGPEVHQTVGQ-KQ--------------------IEE---------------------KI
QPPAL-------------EEPTEDKKY--HELQESS-------KKKNAGEDSET------
-----------------------------------------HELNSEGGEQK-----DSE
I--------------E-------GA----I-SPGEEARHAEEGTEEALVNSKNAPEAEGT
PRTRE----------RTRE-----------------------------------------
--------------------------------------------LTPPEN-QSGEKNKMI
TKIHDK--LVEEDDGYQ-----------------------------------GEGPEPVA
TQNDERSPETPNSLTAEDGDSNSETS---------------D------------------
--------LFVQGDSQ------------------SQANPFRGSV---------QESDINN
PET---------------------------------------------------------
------------------------------------------------------------
---------------------------------------------QKHLALSEEKRIQE-
A------VLAVR------------------------------------------------
-GEDEWVTEEH----AQEHK-G--------QGSG-----T-TGLGPAVEPRGHPNTQ---
---VFIGRD--ENRKSLEPEIPVAPNAG--FTNQLSVRQLPTKKD---------------
-------------------SRKELKVQSPSTKEEEDGALETQEDLVKSLDENNAVSQ---
--KTHPA-------------TLEEEIESPQQLAGE----QNLSTK-EHDPSVSESGLEER
MQRDQELCLVERGAEHSGPLYEVSQEKMLQQTDVTQG--------------------EHQ
N---------------------------------QAQTASVSSPE---------IRRKQL
SASLTNDSSDCLVFFIDRQALQ---------------KYIREFPPDEDPTGAQQILAPHT
LEDKQGRPQREELEPQQEASTP----------------------------------K---
-----------------------------Q------------------------------
------------------------------------------------------------
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-------------

----------------MSTLLENITAIIDLFQQYSSNDKE-NDTLSKKELEELLETEFQP
ILENPND-----------PDTADDFMRILDLDHNKKVDFT-----------E-FFL-M--
-V---------------F-K-L-A-Q-A-Y-YES----TKR---Q-NFK---A-------
SGPKQKKYGHK----------CSSLSRRHRQT--------GK-------KSLT---TTDK
KKHRSSSKNKGRRDDSCP---SGH------------------------------------
----------------------------------------REKNG-KNHHHHTG------
---------------------------KNKRS-------SF--TDLGEETNI-SSI---S
Q--------------------------KREV---------------------GD------
---EHN-------------------YGSEN------------------------------
----------------------------------------RERGSARWEYSRGRQGSRH-
-----GH----SV-DSST-----------HSDSDQGEISS--EGRSRSSTKSRQQSHQH-
-----------------N--SADHPRHSGTGRGRSTIESG----AGSHR---GS-SVGQA
SDSEG QS---ED---SQ--------------------RQSGS---PSGHHHGSNQGQSRD
------------SSR-HSGYH-----Q--------------------GHRTTAPHSHSG-
DSSRHSGSHQGETSAH GQ------------------SRSSTRGRQEA-------------
------------------------------------------------------------
--------------------------R--------------------------------Q
EHSAD--------R--SRRSGPGHA------Q-SSVE-----------------------
---------------------------------------SGEGRH---------------
-------RG-SS----VSQASD---SK---------------G QSEDSHRQ---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----SGYA---STHYH---GSTHGQSRDSSRHSGSHQGHRADAS--Q-SHSAH-------
-------GHS-------DSTARGRQG-----------SSHGHSVDSSRHSS---------
S---HQGET-----------S------------------AHGQ-P---------------
-------------RSSTRARHHQ---G----------S------THGQSRDYS-------
----------GH-SG------SHQGHRADA------------S--Q--SHSA--------
HGNSDSTARGRQAYSHRQSV DSSRH-S-----G---------SHQGETSAH---------
--------------------------------------------------ADRSTHSGAG
HTHSSVESG--EGR---------------HRGSSVS--QATDSEG QSEDSHRQSGYASTH
-------------YHGSTHG----QSRDTSRHSGSHQG--------HRAD----------
---AS--------Q----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------S-HSAHGH---SDSTVRGRQGSSHG-----------------
-------HSVDSSRHSS-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------FHQGETSAC GQPRSST-RGRQ-ESHQKHSGERSRDSGTGRGQSPNES-----
----------GAGRHRESSVSQASD-------------------SEG-QSDDSQTQSGYA
SRH--HQ---------------------GSTH----GQSR---------DNSRNSRSHQG
-HRDD-----GPQSHS----AHG------HSDSTA----TGRQ--GSS---HGQSV----
---------------DSSR----------------------------------HLGSQQG
ETSA---H RQSR-----S-------STRG---------------RQESHLEHS-------
----TDRS--------------------------RHSGAG-------HAQSS---FE---
------------------------------------------------------------
----------------------------------------------SRAV-RHR--APSV
SQASDSE---GQSE-DS-HRQ-------------------S-----------GYASTHYH
GST--------------------HGQSRD----------SS-RHSGSQQGHRAD-----G
PQSHPAHVHS------------DSTARGRQGSSHGQ--------------SVDTSR----
---------------------------------------------HSGSHQRETSAHGQS
RSSTRGR---------QESRQEHSADHSRHSGDGRGQSSAES----GEGRHRGSS-----
---------------------------------VSQASDSEGQSEDSHRQSGSASGH---
--HHGSNHGQSRDSSRHSGYHQGHRATAPH------SHS--THGHSDSTAIGSQ------
GSSYGQSV----------------DSSRH---SGSHQ----------RETFTHGQS----
----------RSSTRGRQESR---------QEHSADRSRH--------------------
-SGDGH-----------GQSSGHDSEGQS--EDSHRQS----------------------
-GYASTHY------HGS----THGQSGDSS------------------------------
----------------------------RHSGS---------------HQGE-------T
S------AHADRSR----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------HSGAGHAQSSLESGAVRH-R---------GSSVSQ-A-S
---DSEG-----------QSEDSHRQSGYASTHY--------------------------
-------HGST-HG--Q-----------------------------------ARDSS-RH
--SRSHQGHRA-------DAS--QSHSAH---GHS--------EST-ARGRQGSS--HGY
SVDS---------------------------------------------------SRHS-
-------------------------SSHQGETSAHGQPRSSTGGRQKSHQEHSADHSRQS
--------------------------GTGHGRS---------PN---------------E
SGAGR-------------------------------------------------------
---------------DRGSSVSQASDSEGQSEDSHRQSGYAS-----RHHQGSTHGQS--
--RDYSRHSG--------------------------------------------------
--------------------------------------------------------SHQG
HRDDGPHSHSAHGHSDSTARGRQGSSHGQSV-----------------------------
--------DS-------------------------------------SRHSDSHQGESSA
HGQSRSSTRGRQESHQE-------------------------------------------
---------------------------------------------RSADRSRHSGAGHAQ
S-----SFESR-------------------------------------------------
--------------AVRHRGPSVSRASDR-EGRSE----------D--------------
--SHRQSGS--ASTHYHGSTHSQSRDSSRHSGSHQGH-------R-------ANRP----
--QSHPAHGHSDS----------------------------------------TARGRQG
SSHGQS-VDTSRH-SGSHQRETSAHGQSRSSTRG-------------RQESRQE------
--------------------------H-----------------SADH--SR-----HSG
DGRGQSSAES--------------------------------------------------
-----------------------------GEGRHRGSSVSQASD----------------
------------------------------------------------------------
----------------------------SEG QSEDSHRQSGSASGHHHGSNHGQSRDSSR
HSRYHQGRRATAPNSHST----------HGHSDSTA----------------IGSQRPSY
GQSV--------------------------------------DSSRHSGSHQRETFTHG-
-----QSRSSTRGRQES-RQKHSADHSRHSGTGHGQSPYES----GVRRHRGSSVIQASD
SEG QSEDSQTQSGYASRHHQGSTHG--------------QSRDN----------------
----------------SR-HSGSHQEHRADGPESHSAHGHSDSTARGGQGSSHGQSVDSS
SHSDSQQG ETSAHGQSRSKHSADRSRHSGA-----------------GHAQSSFESRAVR
HRAPS-----V-------------------------------------------------
------------------------------------------------------------
-----------------------------------SQASDSEGQS--EDSHRQSGYAST-
----HYHG---STHGQSRDSSRRSGSHQGHRADGPQS----HPAHGHSDSTARGRQGSSH
GQSADSSRHSGLSSXEDSH-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----RQSGYASTHYHGSTHGQSRDSSRRSGSHQGHRADRPQSHPAHGHSDSTARARQGS
SHGQPEDSSRHSGSHQGETSTRA-------------------------------------
------------------------------------------------------------
-DHSRHSGARN--A---------QSSF-----ESGAGRHRGSSVSQASDSEGQSEDSHRQ
SGFASTQYHGS------THGQSRDSSK-------------------------------HL
GSHQGHRA------------------------------------NGP-------QSHSVH
GHSDSTARGRKGSSHGQSVDSSRHSGSHQGETSAHGQSRSSTRGRQETQ-----------
---QE------HSADH--SRHSVSGHGRSSFES---------------------------
------------------------------------------------------------
----------------------GAGRHR-------GSSVGQASDSKRQS------EHSGI
QSGSGSGQQGRSTYSQSRDSS---------------------------------------
---------------RHSGSPQGLRAD--APQ---------SH-----------------
-------------------------TAH----------G-HSYSSAIGKQGSSQGQSLDS
TRHSGSHH----------------------------------------GETSAHGESRSS
T-----------------------------RGKKESRQEHSADT----------------
----------SRQSGTGRGRSTI-----------ES---GAGRHGGSSVSQASDSEGQSE
-DSHRQSGSASGHHLESNHGQSRDSSRH--------------------------------
------------------------------------------------------------
------------------SGYHQGHRTT-------APHSHS----AH-----------GH
SD-STAIESQGPSY------------------------------------GQSAGETSTH
G-----QSRSSTRGRQESRQEHSADRSRHSGAGYAQS--------SL--ESGAVRHRG--
-----SSVSQASDSEGQSEDSHRQSGYASTHYHGSTHGQ---------------------
-------ARDSSRH------S---------------------------------------
-----------------------------------------------GSHQG--------
-----------------------------HRA-------------------DASQSHSAH
GHSESTARGRQGSSHGHSVDSSRHSSSHQGETSAHGQP-----RSSTGGRQ---------
-KSHQEHSADHSRQSG----------TGHGRSPNESGAGRDRGS-----SVSQASDSEG-
------------------------------------------------------Q-----
SEDSHRQSGYASRHHQGSTHGQSRDYSRHPGSHQGHRDDGP-HSHSAHGHSDSTARGRQG
SSHGQSVGESSAH GQSR-----SSTRGRQESHQERSAERSR--HSGAGHAQSSLESGAVR
HRGSSVSQASDSKGQSEDSHRQSGYA---SGHQLESNHGQSRDSSRHSG-----------
----YH---RGH------------RATAPNA-----------------------------
-----------HSVHGHSDSTAKGSQGPSYR-----------------------------
----------QSVDSS------RHSGSHQGETSTHGQSRSSTR-----GRQESHQEHS--
----------ADRSRHSG--AGHASG----T---------------EGQS----------
--EVSFGQSA--------------SNHESSGFGSRNQ-----------------------
-PGSIHGQSGDSLRHS--------------------------------------------
-----------------------------------------------------------G
SHSGQISTQRQSDSTH----------VQQSQKADH--GQSDSNGRINQGS----------
------------------------------------SLCQ--------------------
------------------------------------------------------------
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-------------

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------------------DSTGHSWSHEGQTTSGRQTDSSHGHS----------------
------------------------------------------------------------
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--------SSST RGTQGSRHGWDRDSSRHSETHEGQTSSGRQTDSSHGHSGHSTGRGQGS
HHEQGRDSSRHEGSHEGQTFSGRHPGTLRGGRQGSQGREGSRHSGTHERQASIGRQADSS
RGHSSSNTRGTHSSRHEQDTDSSRHFGSGGSD RHGRHSDSSHGRSGSGSRATQESHRRQS
ADSSRHSGTRR---------------GQSP-SASRTHGHRGSSISQASDSEGQSEGSGRQ
STVTQGRSGPLQNQRGSTHGQSGESTR---------------------------------
-----------------------------------------HSGSHQGQTSTHTQSDSAR
GRSGSSTRGSRGSRQEQSGDGSRHSGSGKGPSSSAS------------------------
------------------------------------------------------------
----------SERRHRDSTVSQTSNSEGQSE-DSDGQSVSAHGQTRGTQRGQRESGHGRS
GERTGHSGSHLYQIYPEEQSQSAQRQSRSGTRTTQGSHHEQAPDSSRHSWSHEGQAATQE
HSASNT------------------------------------------------------
------------------------------------------------------------
----------------------------------------------RRTGGPSHGQERDS
SRRAQSHEGQTSRGRHSDASHGHAGSGAR---GTHGSQERDSTGYSWSHE----------
--RPPGRQTDSSHGRSSSSTRGTQGSRHGWERDSSRHSDAHD------------------
-----SQTSRGRH--------------------------------------SDASHGHTG
SCRHGSQERDSTGHSWSHEGQTTS------------G-----------------------
-----------------------------RQTDSSHGRSS---------S------STRG
TQGSRHGWDRDSSRH---------------------------------------------
SDAHDGQDASHGHTGSGARGTRGSQETDSTGHSWSHEGQ-------------TTSGRQTD
SSHGRSS--SSTRGTQGSRHGWDRDSSRHSDAHDGQ--------------T--------S
RGRH--------------------------SDA---------------------------
----------------S-------------HGHAGSGARGTHGSQERDSTG---------
--YSWSHEGQ-----------------TTSGRQTDSSHGRSSS-STRGTQGSRHGWDRDS
SRHSDAHDGQTSRGRHSDASHGHTGSGARGTRGSQETDSTGHSWSHEGQTTSGRQTDSSH
GRSSSSTRGTQGSRHGWDRDSSRHSETHEGQDSSHGH-----------------------
------------------S--------GHSTGRGQGSHHE-----QGRDSSRHEGSHEG-
QT-------------------------FSGRQSDSSRGHSGSGTGGRQGSREEGS--RHS
G--THERQASLVGGRLSRGHSSSNTRGTHSSRHEQDTDSSRHFGAGGTATGRHSD-SSHG
RSGSGSRATQ-ESH----RRQSADSSRHSGTRRGQSPSAS----------------RTHG
HRGSSISQASDSEGQSEGSGRQSTVT----------------------------------
------------------------QGRS---------------GSASGNQRVSTHGQSGE
STRHSGSHQGQTSTHTQSDSARGRSGSSTR--------GSRGS----RQE-------QSG
EGSRDS-------------------GSXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
----------XX--XXXXXXXXXXXXXXXX----X---X---------------------
-----X-XX---------XXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXX-XXXX-----
--------XXXXXXX------------------------XXXXXXXXXXXXX--------
-------XXXX--------------XX--------------------------XXX----
--XXXDPG--SS------GSASGNQRVY--------------TMQSGESTRHSGSHQGQT
ST---HTQSD-----------------------------------------------SAH
--GHSGSSTRGSRGSRQEQS--GDSSRHSGSGRGTTSSASSERRHRDSTVSQTSDSEGQS
EDSDGQSVSAQGQTRGTQRGQRESGHGRSGERTGHSGSHLYQIYPEE-----QSQSA---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------Q
RQSRSGTRTTQGSHHEQAPDSSRHSWSHEGQAATQEHSASNTRRQGDRHGQERDSSRRAQ
SHEGQTSRGRHSDASHGHAGSGARGTHGSQERDSTGHSWSHEGQTTSHGRSSSSTRGTQG
SRHGWDRDSSRHSDAHDGQTSRGRHSDASHGHTGSGARGTRDPGNRQXXXXXXXX-----
--XXXXXXXXXXXXXXXXTKGQSE-------RSGASHHQPT---GRSGS----ASGNQRV
LPRQSGESTRHSGSHQGRRA-HTQSDSARGRSGSSTKRSRGSRQEQSGDGSRHSGSGKRP
SSSASSERRHRDSTVSQTSNSEGQSEDSDGQSVSAHGQTRGTQRGQRESGHGRSGERTGH
SGSHLYQIYPEEQSQSAQRQSRSGTRTTQGSHHEQAPDSSRHSWSHEGQAATQEHSASNT
RRTGGPSHGQERDSSRRAQSHEGQTSRGRHSDASHGHAGSGARN-GSQERDSTGHSWSHE
GQTTSGRQTDSSHGRSSSSTRGTQGSRHGWDRDSSRHSDAHDG-QTSRGRHSDA------
-SHGHTGSGRTRGSQETDSTGHSWSHEGQTTSGRQTDSSHGRSSSSTRGTQGSRHGQSGE
STRHSGSHQGQDSARGRSGSSTRGSRGSRQEQSGEGSRDSGSFLGWRHGSYGNAEYNYGK
TGFGQSNDANDRSLTYSVEFRDPSDKGLSSDYGIDGIK---HYRPRHTGIYGHSSDISKQ
LGFVHSQRYYYYS

----------------MTNLLRSVVTVIDTFYKYTKQDGE-CGTLSKDELKELLEKEFRP
ILKNPDD-----------PDTVDIIMHMLDRDHDRRLDFT-----------E-FLL-M--
-V---------------F-K-L-A-M-A-C-NKV----LSK---E-YCK---A-------
SGSKKRRRSHR----------HREEESETGGE--------EE-------DTSG-----QN
SGYRYSSWSEG-EEHGYS---SGSSRGTPKHRHGS-----------------------G-
-SRRLGRQG------------------------GLSSSENQKGSE-KRRHGSSS------
---------------------------GYSWS--------N--GKERHGSSS-GELEGKR
N--------------------------NYA------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------GQKHGS-----SSKCSGDGGRESHACG
SS---------------------------------------------------------N
SGGCGRR---KT---TSSSCQAGRFGEQGNQSSYT-QSGYQSGSS-GEGHRCISGGWASG
YG---------------------YGS----------------------RTCGQ--PQNC-
GRQQGKG--SCQSSCCGQY-----------------------------------------
-----------------------------------------------G-------S----
-GVSQSSTYSQH-----------GSGSG-GNSSNSHQKRCSSNETS--------------
---KC--------G--QHRSSSGQY------S----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------GFGQHG-----------SGSGQYSGFRHC-----------
------------------------------------------------------------
--------------------------G----------C------SSGQSSGFG-------
----------HH-ES-------TSG-----------------------------------
-----------------------QA-C-----Y---------GQHGSGS-----------
------------------------------------------------------------
-CQYS-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------G-----------------------------------
------------------------EGQYGSG-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------SAQSSGFGHQKS-IS-G-QST-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------C-------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
---------------------------GQHGSGSGQSSGFGQAGS-SSG-QSS-GF---E
HH-EC-RS-QQ-SGY-G-HHEL-GS-GQ-SS----------GFG-QHGSS----------
--------------------------SSQSSGFGQHRSGSCQSSS--------DS-----
----------ERHSEV-----SQRHSRS----AQGQAGSQHGES-GGT------------
------------------------------------------------------------
-------------------------VRG--------------------------------
----------------RHGTA---------HGHSED------------------------
------------------------------------------------------------
-----T------------------------------------------------------
-------------------------------T----------------RHGH-------S
S------Q-------G--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------HSA-------------------HT-GSSQ-RHSG-S
---THGQAGSQ-HG--ESGATVR-GR-------------HGT---AHGRSGDTTRHG-QR
HSGSTHGQAGSQHREHGT------------------------------------------
------------------------------------------------------------
AHGQS--------------------------------------------------GD---
-------------------TTRHGH------------------------SSQGQS-----
------------------------------------------------------------
-------TRSESSQRHSGSTHGQAGSPHGESGATVR------------GRHGTAHEQS--
--GDTTRH------G---------------------------------------------
----HSK----RHSGSTHGQAGSPHGESGAT-----------------------------
------------------VRGRHGTAHEQS-----------------------GDTTRHG
HTSQGQSTWSGSSQAGRRGSSHSEASDSERHSEVSER---------HSGS--THGQAGSQ
HGESGATV----------------------------------------------------
-----------------------RGRQRTAHGQSGDTTRHGHAK----------------
------------------------------------------------------------
--------------------------------------------------RHSGSTHGQA
GSQHGEPGA--TVRGRHGTAHRELGDTTRY----GQS---SQGRSTRSGS----------
-----------------------------------------------------ISERHSG
STHGQAGSQHGESGATVRGRHGTAHGQSGDTTRHG---------------------HASQ
GQSTQSG-----------------------------------------------------
------------------------------------------------------------
----------------------------------RGS-----------------------
------------------------------------------------------------
-SHSEASDRERHSEVSERHSG-----S-THGQAGSQHGESGATVRGRHRSAHGQSGDTSG
HVHS----SQGQSTWSNKQSSHTHAHFGKSHSTSQISSRQRHRSDQAWRHGSYGSAEYDY
GQSGYGPSGGSRTSSRNSSPFRSGSST------------------GQ-------------
-------------RQGS-HHEQSRDSSRQSGTGHGQSSAG-YG---SRKHRESSASQASD
SEGHSEDSGRQ-------------------------------------------------
---------------------------------SVTTHGRPGSASRNQHGSVHGQTRDSS
RHSESHQGRHSDTVHQRSGSS------------------------------------TGQ
RQGSHHEQSRDSSRHEGHSE----------------------------------------
DSGRFGSSSRNQRGSSHGQTGDSSRHSASHQGRHS-----ESVHERSASRPGQREGSHHE
QSRDSSRQSAT--GHGQSS---AGSESSRHRESSVSQSSDREGH--ARDSGRQSVTP---
-----HTRSR--------S------------SSRNQHGASHGQRG--DSSSSRNQHGSVH
GQTGDSPRHSESRQERRSESV------HERSGSSTG-------------Q-RQSGTRHGQ
TSTGSRSSRHSESSVSQASDSEGHS-----------------------------------
EDSGSRSVTTHGRSG---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------SASRNQHGSVHGQTGDSSRHSDTVHQ-------------------------
------------------------------------------------------------
-------------------------------------------RSGSSTGQRQGSHHEQS
SDSSRHSETRH---------------GQTS-TGSGSSRHRQPSVSQASDSEGHSEDSGRQ
S-----------------------------------------------------------
--------------------------------------------------------VTTH
GRPGSASRNQHVSVHGQTGDSSRHSESHQGRHSDTV-----HQRSGSSTG----QR---Q
GSHHE-QSRDS-------SRHSGSQQGQ--------------------------------
-----TSSGSGSSRHRESIVSQASDSEGHAR-DSGRHSE-------T-------------
----------------------THGRSGSSSRNQHGSVHGQTGDSSRHSQFHQGSHGESI
HQRSG------SSTGQREGSHH-----------EQ-------------------------
-----------------------------------------SRDSSRYSGT---------
-----------------A----------------HGETST--------------------
-GSGSSRYRESRVSQSSDS--K--GHSRGSGHVSHSEDQSFSSDQNWSDSNES-LGNRQH
KKKPSQSPSKKHHG----FISGSCGGQDHWSNSNEPAGYGHGYGSSQP-SQ----QRCSS
EVSSYDQ----RRSGSRQPSSSIQHGSGS-----G-QSSAYGQHRSSSG-QS--------
--------S-GFSHHGTGIGQSS-------------SYEQ---H-----------SSTSR
QSPNCSQHGPSL-----------SHSTSCGQYGSGSGQSSSCGQQSSGSSQSLNHGQHRS
ESSQTSSYGQQRTGSGQSSGCRQHRSGSGESSGFNQHRTGLGQSS-----------SYEQ
HGSTSGQSQSCGQHRSSL------------------------------------GQSSSY
GQHGSSQ--YSGHSHHRSGSCQS---SGHSQHGSGSGQS-----------S--------S
CGQRGSRSRESS------------------GFGQHGSGLGQSSSYGQHGSTSGQSSGCGQ
QGSNLGQSSSYG----Q-------------RGSSQYGSSHQHGSGSGQSSSFGQCGSSSR
ESSGFGQHGSGLGQSSSFGQHGSTSGQSSRCGQQRSNLGQSSSYGQHGSSQSSSHSRRRS
S--------------------------SSQSSG------------H---------SRHGS
GSGQSSSYGRHGSTSGQSSSCSQQ-GSNLGQSSSYGQH-----GSS-QSYS---------
------HRRRRSSSS-QSS--------GHS--RHGSGSG-------QSSSYGRHGSTSG-
QSSNCS----QQG------------SNL---GQSSSYGQHGSSQS-----------SSHR
RRRSSSSQS-SGHSRHGSGSGQSSSYGQHGSTSGQSSS----CSQQGSNLGQSSSYGQHG
SSQSYSHRRR-RSSSSQ----SSGHSRH-GSGSGQSSSYGR--------------HGSTS
GQSSNCSQQGSNLGQSSSYG-QQGSSQSSSHRRHRSSSSQSSGHSRH-------GSGSGQ
SSSCG-QHSSSSRESSGFGQHGSGSG-----------------QSSSYGQHGSTSGQSSS
CSQ-QGSNLGQSSSYGQH-----GS-SQSYS----HRRHRSGS----SQ---SSGHSQHG
SGSGQSSSCGQRGSSSRESSGFGQHGSGLGQSSNYGQHSSTSGQSSSCSQQG-SNLGQ--
-----------------------SSSYGQQGSSQYGSSQ----------SSHNSRHRSGS
SQSSGHSRHGSGSGQSSSCGQHSSSSRESSGFGQHGSGLGQSSSYGQHGS-TSGQ-----
--------SSSCSQQGSN---------------------LGQSSSYGQHGST--------
-------SGQSSGCGQQESNLGQSSSYGQQ-----GSSQYGS-----SQSSRNSRHRS--
-GSSQSSGHSRH------GSGSGQSSSCGQRGSSS--RESSGFGQHGSG-LGQSSSYGQH
SSTSGQSSSC-----------------------------------------------SQQ
GSNLGQSSSHGQRGSSQYGSSQSSGFRQQGSGSGQSSSC----GQHGSSSR---------
---------------------QSSGF-------GQHGCGL------------GQSSTYGH
HGS----------TS---GQS------SSCGQHISGSGQ--SSSYGQH------------
--------------ISGSGQSSSYGQ-----------------CGSGLG-------T---
--PNQSRRNGQ----------------------------ECS---GYSQKERSRSCS---
PTSSKSDGY--ESICGQSETCRQQSQGCSQGQTESGYSYSNCNEGQPGGSYRQEKSS-SS
CG----------------------------------------------------------
--------------------------------------------------FR-QFTPCYG
ESRSNTSNTLLICK-EDNRQGGYYDQREGGHYGGRD-----TNSSFYKLRSSTPLYEYVQ
QQRC--------------------------------------------------------
------------------------------------------------------------
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-------------

----------------MPRLLRDVLCVIETFHKYASEDSN-GATLTGRELKQLLQDEFGD
FFQPCV------------LHAVEKNSNLLNIDSNGIISFD-----------E-FVL-A--
-I---------------F-N-L-L-N-L-C-YLD----IQL-----LLS---S-ELRQ--
-VTKP-EKEKPDD------VYLQATT---RD---------GQWTAG---TSPT-------
-----------QEER----------------MLPS----------------------GMA
SLSQLIPEES----------------GAVGNNRVD-PWREAKTHNFPGEASEYNNP----
---KNQHL-------------------------------------------------EGD
-------EQIQEVAQDVQTTEDNEGQ-LKTNK---PMAGSKQTSSPTK-RKG-QDKKISW
EGD-EP----VREQSVS------KIRDQF---------------GEQEGNLE--------
--------------------------------------------TQNSPPEEATQRPSE-
-----------------DQ----------EVRTEK-E--K----------YSNTQEPPL-
------Q------------------GEDE-P-------------SSERA---DLP-----
EQAAARTLSQTQ---KSTDPKDV--CRT----FDTQEPGKDAD------------QTPAE
------------TKN--SGEPEDYGR---------------------TSETQE-------
------------------------------------------------------------
------------------------------------------------------------
------------------KESETKDLPVQGGSRNG----SETSDMK--------DERKER
RGPKTHETAGQ-KE--------------------RDR---------------------KT
RPLVL-------------ETQTQDGQH--QEFQGLS-------KSKDAEKGSET------
-----------------------------------------QYLSS-GGDQT-----HPE
L--------------E-------GT----A-VSGEEAEHTKEGTTEAFVNSKNAPAAART
LGARE----------STQD-----------------------------------------
--------------------------------------------LAPLEK-QSAVENSRV
TKTHDK--PVEEEDDYQ-----------------------------------GEDPESPF
TQNDEGSSETPSSLASEEDNSSSETG---------------E------------------
--------LPVQGDSK------------------SQGDPHGESV---------QGGHNNN
PDT---------------------------------------------------------
------------------------------------------------------------
---------------------------------------------QRQGTPGEKNRAQEA
V------VPAVR------------------------------------------------
-GEDVQLTEDQEQPSRGEHK-Y--------QGPG-----T-KGPGVAVEPSGHPEAQ---
---ESTAGD--ENRKSLEIEITGALDED--FTDQLSLMQLPGKGD---------------
-------------------SRNELKVQGPSSKEEKGRATEAQYTILKSLDEDSSASH---
--KIQLETKK-------TVTS-EEEDESPQELAGEGGDQKSLAKKEEHNSSVPWPSLEKQ
MQTDQQPCSVERGAVHSSPLYQYLQEKTLQQTNITQE--------------------DHQ
K---------------------------------QVQIAQASGPE---------LCS---
-VSLTSETADFSVFFNYNQASQ---------------SYTRGLPLDECPAGA---PAPQA
LEDKQGHPQRERLVPQREASTT----------------------------------K---
-----------------------------Q------------------------------
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-------------

----------------MAQLLNSILAVIKVFEKYAKENGD-RNSLCKKELKQLLLAEFGD
ILR RPND-----------PE TVETILSLLDKDRNGQVDFH-----------E-YLL-L--
-V---------------F-Q-L-A-Q-A-C-YHK----LDD---E-TRG---D-------
RTSQ-QEGEQE-G-----TGNQKFPGS-TGR---QH----RQRHERERQ-----------
-DSHHS-QSERQDRD---------------SH--------------------------YG
QSERRGQDS--HY-GQSERQDGDSCYGQS---------------ERQDRNSRYGQTERQD
QDSRYGQSERG------------Q-GSSSGERLSH-------------KSGS--SKPKSQ
G--YV-------F-------------ALNQCE------KQ------LQ-----------D
SHYGQ-------------------------------------------------------
---------------PE---------------------------RRGQ-R----------
------------------------------------------------------------
----------------------SSYGQSGRLGQDSCSNFTDQQVSGSY----EQSGRLGQ
ESGCSHRNRQEL---D--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------SQYGQTDR---------
------QGQSFH----YGQPDR--QGQSSH-----YGQTDRQGQSSNYDQTDRQDQSSH-
------------------------------------------------------------
------------------------------------------------------------
-------------------YGQTDRQGQSSNYDQTD------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------RQGQSSHYGQTDRQGQSSHYGQ
TDR-QGQSS------------HYGQTDR--------------------------------
----------------QGQS-----------------SNYDQTDRQDQSSHYGQTDRQGQ
SSNY--DQTDRQGQSSHYGQTDCQGQSSG--------------QRGRQG-SS--------
----------PYGQTET---------G---ET---GQNRRFRGSEG-TS-----------
--R-DSRVEPSGRSGRPSQQTQGQEAS-RNQGHRVQSREGQQDSHQAWEP----EEDNQ-
-----------HQQHKLVAQI--QQERP--LCHKEGDWQSRSS-----------------
-------------------EQGHSQAQTRQSHGE--------------------------
------------------------------------------------------------
--------------------------G---------------------------------
------------------------------------------------------------
----QSHQA------EKEQGHQ-----------------SWGRRGHEGQEAPCEVRDRQT
LEEEQIRQARDRHT----------------------------------------------
------------------------------------------------------------
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-------------

----------------MTDLLRSVVTVIDVFYKYTKQDGD-CGTLSKDELKELLEKEFHP
ILKNPDD-----------PDTVDVIMHMLDRDHDRRLDFT-----------E-FLL-M--
-I---------------F-K-L-T-M-A-C-NKV----LSK---E-YCK---A-------
SGSKKHRRGHR----------HQEEESETEED--------EE-------DTPE-----HE
SGYRHSSWSEG-EEHGYS---SGHSRGTVKRRHGS-----------------------N-
-SRRLGRQG------------------------NLSSSGNQEGSQ-KRYHRSSS------
---------------------------GHSWS--------S--GKERHGFSS-GELRERI
N--------------------------KSHV-------------SPSR----EF-----G
EEYESG-------------------SG---------------------------------
--------------------------------------------SKSWERKGHGGLSCGL
EIS--GH-----E-SNST---------QSRSR-GQKLGFS-----RSCSGDSWRRSHAVS
QE---------------------------------------------------------L
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---ME--------D--KAMTVSQEF------T-SCEQ-----------------------
---------------------------------------HGTGL----S-----------
---QSSG---------FEQHVA---G-----------------SGQTCGQY---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------GSRSSQS-
------------SGYDE-HRSSSGK-----------------------------------
-----TSGFGQHRSGSGHSSGFGQHG-----------SGSGQSFGFGQHGS---------
GSG------------------------------------QHES-G---------------
-------------SGQSSGFGQH---E----------S------GSGQSSGFG-------
----------QH-ES-------RSC-----------------------------------
-----------------------QS-S-----Y---------GQHGSGS-----------
------------------------------------------------------------
-SQSSGYGQ--HA---------------------S-------------------------
----------------------------------R-------------------------
---------------------------QTSGFGQH-----GL------------------
------------------GS----------------------------------------
------------------------------G------SGQSFG-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------FGQH-----------------------
-------GSGSGQSSGFGQHES-RS-G-QSS--------------------YGQHS-SSS
SQSSG-YGQHG-------------------------------------------------
------------------SRQTSGFGQHGSGS----GQS----------T---------G
FGQYG-SGS-GQ--SSGFG-QHG-SGSGQS---SGFGQHESTS--GQS------------
--------------------------------S-Y-------------------------
------------------------------------------------------------
-------G--------------------------QH-GFG--------SS-QSSGC----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------GQHG--------LSSG-QTSGF--GQHEL------
-------SSG------------QSSSFGQHGSGSGQSSGFGQHGS-GSG-QSS-GF---G
QH-ES-RS-RQ-SSY-G-QHGS-GS-SQ-SS----------GYG-QHGSKW--TSGFGQH
-SSGSGQ---------STGFGQYGSGSGQYSGFGQHGSGSGQSSG--------SG-----
----------QHESRSGHSSCGQHGFGSSQSSGCGHNGSSSGQT-SGFGQHELSSGQSSS
FGQHGSGSGQSSGFRQHGSGS------------------------GQSSGFGQH------
ESRSHQ------------------SSYGL---HGSGS------------------G----
----------QSSGYGQHGSS---------SGQTSG------------------------
------------------------------------------------------------
-----FGQ------QGS----S--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------SSFGQHES-RSHQSS-YGQHGS-GSSQ-SS----
---GYCQHGSS-SG--H--TTGF-GQ-------------HRS---SS---GQYSGFG-QH
GSGLG---QSSGFGQHGTGSGQSSGFGQHE-SRSY--------QS--SYGQHGSG--SSQ
SSSYGQHGSSSGQTSG------------FGQHRSGSGQSSGFGQYGLGSGQSSGFGQHGS
GTGQSSGFA--------------WHEYRSGQ-SSYGQHGTGSSQSSGCGQRESGSGP---
-------------------TTGFGQHVSGSDNF---------SSSGQHISGSGQSTG---
------------------------------------------------------------
-------FGQYGSGSGQSTGLGQGGSQQVASGSTVH------------GRQETTHGQT--
--INTARH------SQSGQG---------------QSTQTGSRV----------------
-----------RHSEHIHTQVESHYPESGST-----------------------------
------------------VHRRQRTTHGQR-----------------------GDTTRHS
HSGHGQSTQTGSRTTGRQRFSHSDATDSEVHSGVSHR---------PHSQEQTHGQAGSQ
LGESESTV----------------------------------------------------
-----------------------HEKQQTTQGQSGDTSEHGHSGHGQATQTGSRTRGGQR
SRHSESSDSEVHSGVSH------------------------------------------R
PTGDATGHGYSGHGQSTQIGSR--TTGRRGSGHSES-SDSEVHSGGSHRPQSQEQTHGQA
RSQHGESGS--TVHERHGTTHGQTGDTTRY----AHY---HNRQSTQRGSRTTGRRG-SG
HSEYSDSEGHS-----------------------------------------GISHTHSG
HTHSQAGSQHGGSGSSG-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--HGRQGDSEGHSGVSHTHSG-----H-THGQAGSQHGESGSAVHGRQGTIHGQTGD---
------------------------------------------------------------
------------------------------------------------------------
-------------------------TTRHGQSGHGQSTQR--GSRTTG-RRGSGHSEYSD
SEGHSGVSHTH-------------------------------------------------
--------------------------SGHTHGQAGSQHG---------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------ES----GSAVHGRQGTIH
GQTGDTTRHAHYGHGQPTQTG------SRTAGRRGSG-----HSEYSDSEGHS-GGPH--
---------------THSGH----------------------------------------
--TYGQAGSQHGESE---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------STVHE----------------------------------------------
------------------------------------------------------------
---------------------------------------------------RQQTTHGQT
GDITEHGQSGH---------------GQSTQRGSRTTGRRGSGHSEYSDSEGHSGVSHTH
S-----------------------------------------------------------
-------------------------------------------------GHTHGQAGSQH
GESGSALHGRQGTIHGQTGDTTRHGQSGHGESTQTG-----SRTIG--------------
------------------------------------------------------------
--------------RQRSSHSESSHSEVHSE-VSPTHSGHTYSQAGS-------------
----------------------QYGESGSSGHGRQGTTRGQTGDTTRHAQYGHGQSTQTG
---S-------RTTGRRGSGHS------------E-------------------------
-----------------------------------------YSDSEGHSGG---------
-----------------SHT--HSGHTHGQARSQHGESG----SVVHGRLETTYGQTGDT
TRHGHSDYGQSTETDSRST--R---TSHFQSH--SSERQRHGSSHVWK---HGSYGPAE-
-------------------------------YDYGHTGYGPSGG-RRK-SICNSHLSCSD
LIVSKATKGTGRHSL-------------N---HEQ-LMIRYQSGP---------------
--IIGSQES-SHGHSVVTHKQSNNTYVQ-------PGYN---------------------
---TARREGC-------------TYSQSNDHLGSDHGQSISVHVHSKSSS-IRKQQSHTD
NKRSSQ--------------------------------QHLGDTTFHG------------
QVSSHGPSR---------------------------------------------------
VVKGQSG--FSTNERQVYSNGQSNDSYKQSNDSKNFHSTSAQLDDSKHSNT--------I
KGEYSSNPKKTVAQPSASSLNSQDDIFGMSKWECRYLFN---------------------
-TNFN--------------------------------SFGYASRSEVDGSYFYRRNHTQT
--AKFIM----------NAEHSKNQILLHHCMA-----------NEAGISASNSE-----
---------------------------DLGSSG------------H---------E----
---KHSSHGRQESLTRIKGV---------GHLL--GKQNLPISGHKHRKHS---------
------HHDKHEDN-----------------KEEENKENR-----KRPLSLERRNNRKG-
NTGRSKSPRERGGKRHESSSEKKERKGYSPTHKEEEYGQNHHKSSEKEKNKTEITRLEHK
GKRISERQ-----EKKEDGQFDYENTGRMAE----KWTESGHIAINHAIQDEAD--DT-T
ENILEENRRY-ETSRSTHGKSSHRVNRSSNANTSQIPLVEP---------------RRRT
RQRSSVSQDSDSEG HSEDSERRSGLA---SRNHHESVREQSRDGSRHSGSHHQEKGGHGD
SGDSSRQSGTRHTETSSRGQAVSSH EQA---------------RSSPAERHGSRHQQSAD
SSRHSGTGRGQA-SSGVRDRGHQGSSGTQFS----DSEG HSEV----SDTQSVSGHRQAG
PHPHTHQE-SARGR---SVESSGRSGSFLYQVSTHEQSEYTHGRTGPSSARTQGSFNEQA
----------RHSSRHSASHEVRNTIHGHHGSSRGGRQG---------------------
---SHHEQSVDSSGHSGSHHSHTT-SQGRSDASRGESGARSA---SRQTR-HEEQ-----
--------SG DGSRH-------------------------SGS----RHHEA--------
-------SNRADSSRNSQSGQGQSAGFRTSTRRGSSVSQDTD-----SG GYSEDSERQSE
SASTNHHGSVRE------QSRHG------SRHPESHHEDRSAHGQSADSSRQSGTR---H
TETSSRGQAV-----------------------------------------------SSH
--EQARSSPAEKHGSHHQQSA--DSSRHSGTGNGQASSAVSDRGHQGSSGTQFSDSEG HS
EVSDTQSVSGHRQASPHPHSHQESARGRSGERSGRSGSFVYQVSTHE-----QSEYT--H
GRT----------GPSSA RTQ------GSFNEQAR-----------HT------------
--------------QSGQGQSAGFRT-----------------S----------------
-----TRRGSS---------------------------------------------V---
SQDSDSEG H-SEDSERQSESAARNHHGSVREQSRHGSRYPGSHHEDRAGHGQSADSS-RQ
SGTRHTETSSRGQAVSSH----------------------EQARSSPAERHGSRHQ-QS-
----------A---------DSSR---HSGT-GRGQASSAVSDRGHQGSSGT-QFSDSEG
HSEV--SDTQSVS---GHRQAGPHPHTHQESARGRSVESSGRSGSFLYQVSTHEQSEYTH
GRTGPSSAGTQGSHNEQARDSSRHSASHEVRNTIHGHHGS--------------------
------------------SRGGRQGSHHEQSVDSSGHSGSHHSHTTSQGRSDAS-RGESG
ARSAS-RQ-----------TRREEQSG DGSGHSGSRHH---EASNRADSSRHTQSSQGQS
AGFRTSTGRRSSVSQDSDSEG HSEDSERQSEFASRIHHGSVREQSRDGSRHSGSHHQDKV
GHRYSGDSSRQSGTRHTETSSRGQAVSSH EQARSSPAERHGSRHQQSADTSRHSETGRGQ
ASSAVSDRGHQGPRGSQVSDSE GYSEDSDTQSVSGQVQAGPHPHSHQESARGRSGESSGR
SGSFLYQVSTHEQSESTHVRTGPSSGGRQGSRNEQARDNSRHSVSHEGQDTIHGHPGSSR
RGRQGSHHEQSVESSGHSGSHHSHTTSQGRSDASRGQSGSRSASRQTRHEEQSG DGYRHS
GSRHHEASTQADSSRHS----QSGQGQSEWSRRSTLRGSSVSQDSASEGHSEDSERQSES
ASRNPHGSVREQ-SRDVSRHPRSYHHDT----GNHVQSS----SVYSDTTTSKEHGHFGS
LSQDSAYHSGIQS-RGSP----HSSSSYNYHSEGTDMERGQSGLVWRHGSYGSADYDYGE
SRFRHCQHGSVSYNSNPVVFKERSDIRKASEFGEDHPRYYATYINRQPGLYGHSSDISKQ
LGFSQSQRYYYYE

----------------MAQLLSSILSVIEVFHKYAKENGD-CALLCKEELKQLLLAEFGD
ILQRPND-----------PETVETILNLLDQDRDGHVDFH-----------E-YLL-L--
-V---------------F-Q-L-V-Q-A-C-YRK----LDN---K-SYG---G-------
RTSQ-QERGQE-G-----AQDRKFPGN-TGT---QH----RQRHEEERQ-----------
-NSHHN-QPERQDRD---------------SH--------------------------HS
QPERQDRDS--HH-GQAERQDRDSHHGQP---------------ERQDRDSHHNQSERQG
KDFSFDQSERQ------------SQDSSSG------SGKK---VSHK--STR--GQTKWQ
G--HI-------F-------------ALNGCE------KP------VQ-----------D
SHYGQ-------------------------------------------------------
---------------SE---------------------------RLAQ-Q----------
------------------------------------------------------------
----------------------P-----ETFGQDSHFNRTNQQKSGSYC---GQSGRLGQ
ELGCGQMDRQD---QSYHYGQTDRQD-Q--S------S-----------HYGQTDRQGQS
-------------------S--HYS-------------------------------QT--
---DR----QDQSSHYSQTDRQG-------------------------------------
------------------------------------------------------------
-----------------------------------------------QSSH---------
------YGQTNRQG---QCYQYGQTDRQGQSSHY-SQTDRQGQSSHYGQ---T---H-R-
---------------------------------------QGQSSHYGQPDR---------
------QSQS------------------PH-----YGQTDRQDQSSHYGQTDRQGQSSH-
------------------------------------------------------------
------------------------------------------------------------
-------------------YGQTDRQ----------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------QSPHYGQ
TNR-QGQSS------------HYGQTDR--------------------------------
----------------QGQS-----------------SHYGQTDRQGQSSHYGQTDRQGQ
SSHY--SQMDRQGQSYHYGQTDRQSQSSHYGQTDRQSQSYHYGQTDRQGQSS--------
----------CCVQSQT---------G---EI--QGQNKYFQGTEG-TR-----------
--K-VSYVEQSGRSGRLSQQTPGQKGY-QNQGQGFQSRDSQENSHQVWEP----KEDSQ-
-----------HHQHKLLAHI--QQERP--LCHKGRDWQSCSN-----------------
-------------------EQGHRQAKTRQSHGE--------------------------
------------------------------------------------------------
--------------------------G---------------------------------
------------------------------------------------------------
----QSHWA------EEEQGHQ-----------------SWDRHNHEGQEGPCGTQDRQT
PEDEQNHQRRDRQTHEDEQNHQ--------------------------------------
--RRDRQTHEDEQNY-Q-------------------------RRDRQIHEDEQNHQR---
------------------------------------------------------------
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-------------

----------------MPQLLRNINGIIEAFRRYARTEGN-CTALTRGELKRLLEQEFAD
VIVKPHD-----------PATVDEVLRLLDEDHTGTVEFK-----------E-FLV-L--
-V---------------F-K-V-A-Q-A-C-FKT----LSESP-EGACG---S-----QG
SGSL-----HP-G----ASRELGE-GQRSGTEV--GRAGKGQCCEG--------------
-------SS-------------------------------------------------QG
QSEQA-----------SRGQNR--------PR-----PGAQTQG----------------
------------------------QATSSVWVSSHDR------------------QAGSQ
SQERT-SLQTQLWGHKEKTQAIGEGQSHQTRE------M--------------R-----P
Q---------TREQDRARQTGETV-TGSG-------------------------------
--------------------------------------------TQTQA--GATQTLDQD
NSHQTGSTSTQTQESTNGQNRGT----------------E--------------------
-----TYGQGRSQTSQ-----AVTGGHAQTQ-------------AGSHT-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---QTSQAVTGGHAQT----------------QAGSHTQTSQAVTG-----GHTQAGSRT
Q---------------TSQAV----TG--HT----------QTQAGSHTQTV--------
-----------------------------------------E------------------
------------------------------------------------------------
----------------------QDRSQTVSHGGARE------------------------
---------------------------------------------------QGQTQ----
TESGSGQRWTPASKPEA-GE----------------------------------------
---------TVLG-------------------------GQAQTGANPESGRQDWSSL---
-SV----------TEGQG-----------------------DRDRQ--------------
--------VVEEWVDDHSKET---AILRPDHGS----LHT--------------------
------------------SVSSAQGRDAAQ------------PE-AKRAIT-TRE-----
----------L--------------------------YSYLRSDQP--------------
------------------------------------------------------------
------------------------------------------------------------
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-------------

----------------MPKLLNSILNVSKVFQKYAEHHGK-HALLSKEELKQLLLTEFGD
ILRRPND-----------PDTVEIILEHLDRDRNGYVDFQ-----------E-YLL-L--
-V---------------F-Q-L-V-Q-A-C-HRK----LDS---K-VCG---A-------
GTSSQKEQGQK-G-----MQSHKFPEN-MGR---QD----GQ------------------
-SSHHS-WSEGQSQDVQH--DQ-SQRQDKDSH----------------------------
--------------GHSERHDTDSHYGQSERQDRD---SHHGQSEKFHQDSYHSCSERQD
TDYSSD-------------------------HLSY-------------KSSN--DQPKSQ
G--YI-------F-------------ALNQSE------NP------AQ-----------V
SHYGQS-----------------KTFRRQS------------SHGQ-SGRFR--------
--------QDSYSSQTS----------R-----QQPGSYEQY-GKLHQ-KSGNSQTDRQA
QNSHYGQPDKQGNSFQYGQTD---------------------------------------
-----------------GQGQSFHYGQTKN------------KGQNFHY---GQKGGQSQ
SSQLGQTGI---------------------------------------------------
--------------------------------------------------------K---
---G-----Q-SS-HQ-G-QT-DR-QN---------------------------------
------------------------------------------------------------
-------------------------------SY-QD---QT-HS---Q------------
---SS-QQ-GQ-T-----------------------------------------------
------------GN-RQ-TYH--------QG-QTG-SQGQ-SSQ-QGQ-TGSQ-DQS-SH
W-HQT-DR--QT-YHQ-GQT-GSQ-GQSS-QQG-QTGS-QDQ-SS-RWH-QT-DRQTYH-
QGQ---------------------------------------------------------
------------------------------------------------------------
-------------------TG-SQG-QS-SQL-GQ-TG----------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------SQDQSSRWHQ
TDR-Q--TYHQGQT----------------------------------------------
--------------GSQGQSSQQGQTGNQDQSSHRQTYHQGQTGSQDQSSCWHQTDRQ--
TYHQ--GQT------------------------DRQGQSSQQGQ----------------
--------------TSREGQSYHCGQSGIGKTELQGQNRYFQGTDE-TR-----------
--R-HSYVEQSGGSGKLSQQTSREEVN-QTQRQRFQDRRDQKTHHQAWKL----EKDN--
-------------QHKLLAQI--QQEEP--HSHNEYDWQSQSS-----------------
-------------------EESH-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------WE-------EKEHPQ-----------------FWDRHSLEDQESLYEMQ---T
HEDEQSHQTKDTQTYVDKQNQK--------------------------------------
--RQHRQTHEENQDH---------------------------RHGRQTHEDEQNYERKDK
DQ----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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---------------------------------N--------------------------
---HHQQWNRQTHEENERYQGSQDR-----------------------------------
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------------------------------------------------------------
-------------------------------FRSFPNKERFHKNED--------------
----------------------DQCQGS---------EGRHFH------------QTHRG
GRSQRREQQGNHSTKTA-NSPNPLNDYVREQAVYQY------------------------
------------------------------------------------------------
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-------------

----------------MSQLLRNINGIIEAFRRYARTEGS-CTALTRGELKRLLEQEFAD
VIVKPHD-----------PATVDEVLRLLDEDHTGTVEFK-----------E-FLV-L--
-V---------------F-K-V-A-Q-A-C-FKT----LSESP-EGACS---S-----QE
SGSL-----HS-G----AWQELNE-GQRSGTEV--GRVGKGQHYEG--------------
-------SS-------------------------------------------------HG
QSEQP-----------SRGQNR---------------PGAQTQG----------------
------------------------QATGSAWVSSYDR------------------QAESQ
SQERT-SPQTQRSRHTEQTQRAGEGKRHQTTE------M--------------R-----P
ERQP-----QTREQDRTHQTGETV-TGSG-------------------------------
--------------------------------------------TQTQA--GATQTVEQD
SSHQTGRTSTQTQKATNDQNRGT----------------E--------------------
-----IHGQDRSQTSQ-----AVTGGHAQI------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------QAGTHT-----------------------------------------------
------------------------------------------------------------
---QTPTQTVEQDSSH----------------QTESTSTQTQGSTNDQNRGTEIHGQGRS
Q---------------TSQAMT---GG--HA----------QTQAGSHTQTV--------
-----------------------------------------E------------------
------------------------------------------------------------
----------------------QDTSQTVSHGGAGE------------------------
---------------------------------------------------QGQTQ----
TQPGSGQKWTQVSNPEA-GE----------------------------------------
---------TVPG-------------------------GQAQTGASTESGRQEWSSTHPK
HYV----------TEGQG-----------------------DIQPT--------------
-------VVGEEWVDDHSRET---AIFRLDQGN----LRT--------------------
------------------SVSSAQCQDAAQ------------PE-EKRGIT-ARE-----
----------L--------------------------YSYLRSNKP--------------
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-------------

----------------MPQLLQNIHGIIEAFGCYARSEGG-CKVLTRGELKRLLEHEFAD
VIVNPHD-----------PSTVDEILRLLDEDNTGTVEFK-----------E-FLV-L--
-V---------------F-K-V-A-R-A-C-FKT----LSEIP-RGA-----------DK
SEGC-----YP-G----SSKELAQ-GQIGGPGV--GRDAAEQCRED--------------
-------SS-------------------------------------------------WG
QRDRA-----------SKEQVR---------------VGTHTQS----------------
------------------------QESYPTQVSSHNR------------------EVESQ
RQKRV-SQQTQVTGQVEQTLRTEDKSW--SRE------R--------------R-----S
ERQS-----QTSQH-----TEET-------------------------------------
-----------------------------------------------TA--G--------
--------AFQTQGSACGQNRGT----------------N--------------------
-----SHSQDRSQAGQ------AATQHDQTQ-------------AGSHTQTHTQREEEGW
RQQTGSGSIQTQ---ESIYDQNRETE-----------------------------THSQD
RNQ---------------AGQAAKE-----------------------------------
-------QHQAQAEPY--------------------------------------------
------------------------------------------------------------
------------T-----------------------------------------------
------------------------------------------------------------
---QTHTQTVERGRSQ----------------QAGNSSIQTHGAIYDQNRRTEIHGQDSS
R---------------AGQVGT----G--HF----------QTQVGSYSQTL--------
-----------------------------------------E------------------
------------------------------------------------------------
----------------------HDRSQAAGQIGAPE------------------------
---------------------------------------------------KRQTQ----
IPSGMGQGWTPVSNCET-GE----------------------------------------
---------PGLG-------------------------GQVQTQTST------VEENHP-
-SP----------KGGQR-----------------------ESVPT--------------
-------VIRDEWVNDHTREI---VIQSQNPGS----PHP--------------------
------------------RVPSAQGQDTAQ------------ME-EKKGIT-AKG-----
----------L--------------------------YSYLKTDRP--------------
------------------------------------------------------------
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-------------

----------------MPQLLRGILCVIETSHEYAREDGN-GTTLTCTELERLIQGEFGD
IRQ PNM------------TH AVERIFNLLDIDSNGTISFD-----------E-FVL-A--
-V---------------F-N-L-L-N-L-C-EFX----XXX-----XXX---X-XXXX--
-XXXX-XXXXXXX---XXXXXXXQCG---GI---------RLQAER---TSPP-------
-----------QDKL----------------VLPS----------------------GMA
SSAQESSEER----------------GPGEHFRED-PEGGSKTGNSLGEASGHNE-----
----NQYM-------------------------------------------------EGD
-------EQNQEVTPDIE---DKGAQ-LD-------------------------------
----KS----QWKQNNT------NTRDQF---------------GEQEENLG--------
--------------------------------------------TQSSLPEEIAQKPSE-
-----------------DP----------EFATGK-E--E----------YSKIQEPSL-
------Q------------------QKYE-P-------------NLEHG---NLP-----
EQAAARKLSQIQ---KSIVSEDD--ERI----YETQESGKDAN------------RTPPV
------------TNN--SAEPEDDSR---------------------TSETQE-------
------------------------------------------------------------
------------------------------------------------------------
------------------KACETKGMPVQGDSRNV----SETHDV-------------EG
RNPKVHGITRQ-KE--------------------SER---------------------KS
QIPAL-------------EAQTQDEKY--QELQGPS-------KENSAAKGSET------
-----------------------------------------QNLSSEGRGQN-----HPE
L--------------K-------GA----A-APEEEVRHTEESIAHALVTCRNTPAVEGT
PRARK----------RTQE-----------------------------------------
--------------------------------------------SALLKS-HSGGENRRI
TNIQDK--SIKDH-GYQ------------------------------------EEPEPPA
TRIHEGSSEIPNSLAPD-GVRSSEMG---------------D------------------
--------LLAQEDSQ------------------SQGDPPEGSA---------QGGCNNN
PDS---------------------------------------------------------
------------------------------------------------------------
---------------------------------------------QKQVAP-----AQEA
V------VLAVR------------------------------------------------
-REDEQLMEEKKQPTGRKHK-S--------KDSG-----T-KGPCPAMEPNGHPEAE---
----SIVGG--KNVKSLKTEIQGSLDAD--FNDQLSVTQKTTKGD---------------
-------------------SRKELKFQDPISKEEEGGAMETQESLFKSLDGNNSASR---
--ETHLVTKE-------PATL-QEEGESPQELAGECDDQQNPTKK-GHNSSVPQSGLEER
RVRDREPCSVERDAAQSSPLYSYPKEKMPQQTDITQE--------------------EHQ
N---------------------------------QAQTARTSGPE---------LSKYQS
RASPTSEMLDHPAFFNHSQPIH---------------QCTRGRLSDEDPADPRQRAAPQT
LEDKQVHSQRKETEPQREMGTT----------------------------------K---
-----------------------------Q------------------------------
------------------------------------------------------------
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-------------

----------------MSRLLRGIFCVIETFHKYTSEDGNSKARLTQRELRQLLEGEIGD
FLQPHI------------FHAVERKLNLLDTDRDGTISFE-----------E-FLL-A--
-I---------------F-S-L-L-N-L-F-YLD----T-S-----LLY---S-EPRL--
-VSKS-EK--MDG------VDLRAAT---RS---------SQQVVG---VGPT-------
-----------QKRL----------------LFAP----------------------EMA
SSAQPSHEDG----------------EAGGHNKMS-PWEDIKTQNLPQEVSEPHHP----
---ENQHP-------------------------------------------------EED
--------DGEEVAQDVPATEYDGVQ-FQRNM---PGEVSKQSHSPTQ--------VIPK
EEG-RA----VRKQSDT------KVRDHM-------------------------------
-----------------------------------------------------AQRPSE-
-----------------GE------------------EQ-----------HSITQDPFP-
------Q------------------KEDR-V-------------ISEHT---DSP-----
LEAAAGKPPQTQ---KVIELTDD--SRI----SETQEPGEDAG------------RPSTR
------------TTN--LENLKGESR---------------------TSETHGFPAQE--
------------------------------------------------------------
------------------------------------------------------------
------------------GKHETQNQSAERGS--------ETATQG--------K-----
------REEER-NE--------------------RDR---------------------KA
RPPTP-------------EAQTQDEKC--QEFSGPW-------REP------GT------
-----------------------------------------QGLSSEEGNQN-----FPE
I--------------K-------EE----S-VSGTEARHSENDAAEAFLIHKSSPETEET
LGTKG----------RSQE-----------------------------------------
--------------------------------------------LARLEN-PSQGKNHRA
TRIHDK--PVRKEDHSE-----------------------------------GDDPEVSV
TQS---------DLAPEVGGTSSDSG---------------E------------------
--------PQVPGGVQ------------------SQADTAGDSK---------QGSDDNK
PDP---------------------------------------------------------
------------------------------------------------------------
---------------------------------------------QKQGAPGKSLRVKKA
V------VLSIQ------------------------------------------------
--EDRQFWEEQEQPAREK----------------------QDTLGAAVQPRETQEVQ---
---EFTAGG--ENRKSPEAEGSGAQ-----------------------------------
------------------------------------------------------------
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-------------

----------------MPQLLRDVLCVIETFHKYASGDSD-EVTLTHRELKQLLHNEFDD
FLQPYV------------LRAMERNLNLLDNDSNGTISFV-----------E-FVL-A--
-I---------------F-N-L-L-N-L-C-YLD----VKS-----LLR---T-KLRQ--
-VSKL-EKEKPSE------VDLQATT---SN---------GQRTAR---TLPG-------
-----------QEKV----------------ILPS----------------------VIS
PSSQLSPEEN----------------GAVGHSRVD-PRGNAKTHHPPRKAPQHNDS----
---MNQHL-------------------------------------------------AGD
-------EQSQEVAQSVPATEDNGAQ-LKTNK---PVAGSGQTGSSTK-EGG-QNKEIPR
EGD-EL----ARERSGT------KTRDQF---------------GDQEGNLG--------
--------------------------------------------NQNSLPEETTQRLFE-
-----------------DQ----------EIRAEQ-GIKK----------HSKTQGPPL-
------Q------------------GETE-P-------------SLENA---DQP-----
EQAAAKIASQMQ---KATDPEGD--CRT----AE--------------------------
--------------------------------------------------TQESPAQE--
------------------------------------------------------------
------------------------------------------------------------
------------------KEHETTSLPVQGRGRNI----PETPGTG--------AEKQQG
TAPEAHGSAEQ-KE--------------------HDR---------------------KT
QPSVL-------------EAQTQDEKC--HRFQGLS-------NESDTKKDSET------
-----------------------------------------QNQSSE-GDQN-----DPE
R--------------E-------GA----A-VPGIEAKHTEEGPTEALVNSRNGPAAEGT
PGTRE----------RTQE-----------------------------------------
--------------------------------------------SAPLEN-QSEGEKSRV
TKSYDK--PVKENDGYQ-----------------------------------GEDPELSV
TQNDEGSSETPNSLAPKEGNSSTETK---------------E------------------
--------LSVQEDSQ------------------SQVDPHGESV---------QGDHNNN
PNT---------------------------------------------------------
------------------------------------------------------------
---------------------------------------------QKQRAPAEKDRAQEA
V------VLIVR------------------------------------------------
-GEDVQLTEEQEQPTREEHK-S--------PGSE-----T-KGPGAAMKPSGHPEAQ---
---ESTARG--EKGKSLETKFPGALDAN--FTDQLSIMQLPEKGQ---------------
-------------------SRSELKIQGSSTKEEEGGVPEFQDTLVKDLDEGNSVSS---
--KTHPGTE--------------------------------------DKSLMSQSSLEEM
MLRDQEPHSVERNTVHSSSPRQYLQEKILRQTNNTHE--------------------EHQ
N---------------------------------QAQIAQASGLQ---------LCNDQS
RASLTSEISDCPVFFNHSQVSQ---------------QYTKEFLPVEEPTGAQKTSAPQA
LEDKQGHRQRGEPVPQREARTT----------------------------------K---
-----------------------------Q------------------------------
------------------------------------------------------------
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-------------

----------------MPQLLGNIDGIIQAFTRYAKTEGD-CTTLTRGELKKLLEQELAD
VIVKPHD-----------PATVDQVFRLLDEDSKGTVDFK-----------E-FLL-L--
-V---------------F-K-V-T-Q-A-C-YKT----LNESP-EGACG---T-----QE
PESQ-----HP-G----STQQMRD----DHTST--GRVEREQDHNR--------------
-------NR---------------------------------------------------
EEERT-----------FPGQNR--------NN--L-TTRTQTRG----------------
------------------------QDFTSAEVCGQER------------------QPETQ
EQERG-IQQIREQGRTHQTSDTLTGGQ----S------Q--------------T-----H
TGTT-----QTREQGRTHQTSDTL-TGGQ-------------------------------
--------------------------------------------SQTHT--GTTQTREQG
RTHQTSDTLT--------------------------------------------------
------------------------GGQSQTH-------------TGT-----TQTREQGR
THQTSDT-----------------------------------------------------
--L---------------TGGHLTGG----------------------------------
-------QSQTHTGT-----TQT--------------REQDRTH--------------QT
SDT--------------------------------------------------------L
TGGQSQTHTGTTQTRE-----Q-------------------------GRTH---------
-------QTSD------TLTG-GQS-----------------------------------
QTHAGTTQTREQGRTH-----------------Q--------------------------
----------------TSDTLT---GG--QS----------QTHTGT-TQTR--------
-----------------------------------------E------------------
------------------------------------------------------------
----------------------QGRTHQTS-DTLTG------------------------
---------------------------------------------------D--------
------------------------------------------------------------
--------------------------------------QSQIRIHISHSGKQDQSHH---
-------------KNEWM-----------------------TGGQSQT------------
---QESTIGGQDWNRQQTRET---VVEQQDQRN----LHA--------------------
------------------SESEIHGQKTTQL----GGAS--QAQGGKLGLN-AQS-----
----------L--------------------------YSYFKDNKP--------------
------------------------------------------------------------
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-------------

----------------MPQLLRSALCVIEMFHEYAREDGD-GATLTCRELKQLLQGEFEG
MLQPNT------------IHAVERILNILDIDSNGTISFD-----------E-FVL-A--
-I---------------F-N-L-L-N-L-C-YLD----IQS-----LLN---S-EPIQ--
-VSKP-ENENPDD------GESQATS---GN---------GLQTER---TSPP-------
-----------PDKL----------------MLPS----------------------GVA
SPAQDSSEER----------------GSIEHNRED-LQRDSMTGNLPREASGHNDH----
---KNQYL-------------------------------------------------QGD
-------EQSQEVTQDVQALGDSGVQ-LETNK---PMIESEET----TKREE-QDKEIPR
AGDKLP----ASEQSDT------STRYQF---------------GEQEENLG--------
--------------------------------------------TQSSLPKETAQRPSK-
-----------------DQ----------EVAAEK-DVKE----------HSKIQDPSL-
------Q------------------AEDE-P-------------RPEHT---VLS-----
EQ--------SE---KSTEPEND--GKT----PEAQEPGNNAS------------RTPPE
------------TNN--SADPKDDGR---------------------TPETQEPPIQE--
------------------------------------------------------------
------------------------------------------------------------
------------------KEHETQDMPAQGDIRNV----LETHYVR--------AEQKER
RIPKAHGTTGQ-KE--------------------SER---------------------KS
QTPAL-------------EAQTHDEPQ--GS------------KERHAAKESET------
-----------------------------------------QNLGSEGRDQS-----HTE
I--------------E-------GG---AA-APKEEARHAEESTAYIFVNSKNAPVVDET
PRARE----------RTQE-----------------------------------------
--------------------------------------------SAPLES-QSGTKNRRI
TKIQDK--PIKEKDGYR-----------------------------------EEDLEPPS
THIDEGSSETSKSLAPEPGVSSSDTG---------------D------------------
------------------------------------------------------------
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-------------

----------------MPQLLRNINGIIEAFGRYARMEGN-CKMLTRGELKRLLEHEFAD
VIVKPHD-----------PATVDEVLCLLDEDNTGTVEFK-----------E-FLV-L--
-V---------------F-K-V-A-Q-A-C-FKT----LSESP-EGACG---S-----QE
SGIC-----PA-G----DSQELGE-EQNRRTEV--EPAREGQHCEE--------------
-------SQ-------------------------------------------------HR
QSTQA-----------SRGQVG---------------ARAQTHG----------------
------------------------QDIG------QDR------------------QSKSQ
RQERE-SWQTQAGECTQQTQRVGEDKSHQTRE------R--------------E-----S
ERQS-----QAREQDRAHQTSETV-TGTG-------------------------------
--------------------------------------------TQTQT--DTTQTMEED
RSSQIGSPGTQPQEST--QTRGT----------------E--------------------
-----VQGQDRSQTSQ-----IVAGEHVQTP-------------GGV-----TQTTEQDR
SGHIGSPGTQPQ---ES-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------THGQTRGTEV----------------------------QGQDRSQTSQTV
AREHVQTPG---------------------------------------------------
------------------------------------------------------------
----GVTQTMEQDRSG----------------QIGSPGTQPQESTHGQTRETEVQGQDRS
Q---------------TSQVVT---GG--HI----------QTQAGSQTQTH--------
-TQTM------------------------------------E------------------
------------------------------------------------------------
----------------------QGKSQSARHTGDRD------------------------
---------------------------------------------------EGQIQ----
RQSDSGQRWTQVSHYEA-GE----------------------------------------
---------AEMG-------------------------GQAQAGASTLTGRQDRSSTQPR
CSV----------TGGQR-----------------------ESEST--------------
-------VVTQEWVDDHTRDT---AIPRQDQGS----LHS--------------------
------------------GMLSAQGPDTAQ------------PE-GKRGLT-ARG-----
----------L--------------------------YSYFKSNKP--------------
------------------------------------------------------------
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-------------

----------------MTDLLRSVVTVIDVFYKYTKQDGE-CGTLSKGELKELLEKEFHP
ILKVRR-----------------------------------------------LSW-I--
-I---------------W-V-G-P-K-S-C-NKG----PYE---R---------------
---KKKRHRHR----------EGGED--HVKT--------KV-------DTGG-------
------------------------------------------------------------
---------------------------------------------------DAT------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------RNAWNQQKPEEAR---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------NDL----------------------PLERP--EGNC-
GGQWRTG--SSQSS-CGQY-----------------------------------------
-----------------------------------------------G-------S----
-GGSQSCSNDQH-----------EYGSC-GRFSNSSS----SNEFS--------------
---KC--------D--QYGSGSGQS------T-SFEQ-----------------------
---------------------------------------HGTGL----S-----------
---QSSG---------FEQHVR---G-----------------SGQTCGQH---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------ESTSSQS-
------------LGYDQ-HGSSSGK-----------------------------------
-----TSGFGQHGSGSGQSSGFGQCG-----------PGSGQSPGFGQHAS---------
V-----------------------------------------------------------
-------------SGQSSGFEQH---G----------S------VSGQSSGFG-------
----------QH-ES-------RSR-----------------------------------
-----------------------QS-S-----Y---------GQHGSGS-----------
------------------------------------------------------------
-SQSSGYGQ--YG---------------------S-------------------------
----------------------------------R-------------------------
---------------------------ETSGFGQH-----GL------------------
------------------GSGQSTG-----------------------------------
------------------------FGQYGSG------SGQSSG-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------FGQH-----------------------
-------GSSSGQSSGFGQHES-RS-G-QSS--------------------YGQHS-SGS
SQSSG-YGQHG-------------------------------------------------
------------------------------CS----GQY----------S---------G
-----------------FG-QHV-SGSGQS---C-------------HS-----------
--------------------------------S-Y-------------------------
------------------------------------------------------------
-------G--------------------------QH-GFG--------SS-QSSGC----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------GQRG--------SSSG-QTSGF--GQHEL------
-------SSG------------QSSSFGQHGSGSGQSSGFGQHGS-GSG-QSS-GF---G
QH-ES-RS-GQ-SSY-G-QHSS-GS-SQ-SS----------GYG-QHGSRQ--TSGFGQH
-GSGSSQ---------STGFGQYGSGSGQSAGFGQHGSGSGQSSG--------FG-----
----------HHESKSHQSSYGQHGSGSSQSSGYGQHGSSSGQT-SGFGQHRSSSGQYSG
FGQHGSGSGQSSGFGQHGTGS------------------------GQYSGFGQH------
ESRSHQ------------------SSYGQ---HGSGS------------------S----
----------QSSGYGQHGSS---------SGQTFG------------------------
------------------------------------------------------------
-----FGQ------HRS----GSGQ----S------------------------------
----------------------------SGFG----------------QHGS-------G
S------G----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------QS--S
G-FGQ-H-----------ES-GSGQSSGFGQHES-RSSQSN-YGQHGS-GSSQ-SS----
---GYGQHGSS-SG--Q--TTGF-GQ-------------HRS---SS---GQYSGFG-QH
GSASG---QSSGFGQHGTGSGQSSGFGQYE-SRSR--------QS--SYGQHGSG--SIQ
SSGYGQHGSNSGQTSG------------FGQHRSGSGQSSGFGQYGSGLGQSSGFGQHGS
GTGKSSGFA--------------QHEYRSGQ-SSYGQHGTGSSQSSGCGQHESGSGP---
-------------------TTGFGQHVSGSDNF---------SSSGQHISDSGQSTG---
------------------------------------------------------------
-------FGQYGSGSGQSTGLGQGESQQVESGSTVH------------GRQETTHGQT--
--VNTTRH------SQSGQG---------------QSTQIGSRVTRRRR-SSQSENSDSE
VHSRVSH----RHSEHIHTQAGSHYPKSGST-----------------------------
------------------VRRRQGTTHGQR-----------------------GDTTRHG
HSGHGQSTQTGSRTSGRQRFSYSDATDNEVHSGVSHR---------PHSQEQTHSQAGSQ
HGESESTV----------------------------------------------------
-----------------------HERHETTYGQTGEATGHGHSGHGQSTQTGSRTTGRQR
TSHSESTDSEVHSGVSHRTHSREHTYGQARSQHGEPE------FTVHERH-----GTTHG
QIGDTTGHSHSGHGQSTQRGSR--TTGRQRSSHSES-SDSEVHSGVSHTHT--RHTHGQA
GSQHGQSES--IVRERHGTTHGQTGDTTRH----AHY---HHGVTTQTGSRTTGRRG-SG
HSEYSDSEGYS-----------------------------------------RVSHTHSG
HTHGQARSQHGESESIVHERHGTIHGQTGDTTRHA---------------------HSGH
GQSTQTGSRTTGRRSSGHSEYSDSEGHSGFSQRPHSRGHTHSQAGSQHGESESIVDERHR
TTHGQT-------------------------------------------------GDTSG
HSQSG---------------HGQSTQSGSSTTGRRSG-----------------------
------------------------------------------------------------
--HSESSDSEVHSGGSHTHSG-----H-PHSQARSQHGESESTVHKRHQTTHGQTGDTTE
HGHP----SHGQT--------------------------TQTGSRTTGRRG-SGHSEYSD
SEGH-----------------------------SGVSHTHSGHTHGQAGSHYPES-----
-GS------SVHERHRT-THGQTADTTRHGHSGHGQSTQRG--SR-TTGRRASGHSEYSD
SEGHSGVSHTH-------------------------------------------------
--------------------------SGHAHGQAGSQHGEPEFTVHERHGTTHGQTGDTT
RHAHSGHGQSTQRGSRT-----------------------------------------AG
RRGSGHSESSDSEVHSGVSHTHSG---HT----------------Y---------GQARS
QHGESGSAIHGRQGTIHGQTGDTTRHGQSGHGQST-----Q-------------------
----------------------TGSRTTGRQRSSHSESSDSEVH--SEASPTNSGHP---
-----H----------------------------SQAGSRHGQS----GSSGHGRQGTTH
GQTGDTTRHAHYHHGVTTQTG------SRTTGRRGSG-----HSEYSDSEGYSR-VS---
--------------HTHSG-----------------------------------------
-HTHGQARSQHGESE---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------SIVHERHGTIHGQTGDTTRHAHSGHGQSTQ----------TGSRTTGRRSS
GHSEYSDSEGHSGFSQRPH-----------------------------------------
----S-------------------------RGHTHSQAGSQHGESESIVDERHRTTHGQT
GDTSGHSQSGH---------------GQSTQSGSSTTGRR-SGHSESSDSEVHSGGSHTH
SG----------------------------------------------------------
------------------------------------------------------------
--XXXTVHERHGTTHGQTGDTTRHAHSGHGQSTQRG-----SRTAG--------------
------------------------------------------------------------
--------------RRGSGHSESSDSEVHSG-VSHTHSGHTYGQARS-------------
----------------------QHGESGSAIHGRQGTIHGQTGDTTRHGQSGHGQSTQTG
S----------RTTGRQRSSHS------------E-------------------------
-----------------------------------------SSDSEVHSET---------
-----------------S--PTNSGHPHSQAGSRHGQSG----SSGHGRQGTTHGQTGDT
TRHGHSSYGQSTQTGSRSS--R---TSHFQSH--SSERQRHGSSQVWK---HGSYGPAE-
-------------------------------YDYGHTGYGPSGGSRKS--ISNSHLSWSI
DSTANKQLS--RH-----------------------------------------------
------------------------------------------------------------
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-------------

----------------MPQLLRDILCVIETFHKYAREDA---ATLTCTELKQLIQSEFED
IFQPCA------------IHAVERNLNLLNIDSNGAISFD-----------E-FVL-A--
-I---------------F-S-F-L-N-V-C-YLD----TQS-----LLN---S-EPRQ--
-VSKP-EG-MPHD------MGLQVTN---ET---------DQWTEG---TSQT-------
-----------QDKV----------------VLPS----------------------GTA
SSTHLSLE-E----------------RAVEHNRVD-PQGHTTAHKLPVETSEHSDS----
---KNQHL-------------------------------------------------KGD
-------EQSQKVDQDVSATGDSRTQ-RETSK---PMAGSEQISSHTK-GEG-QNKEILQ
KGD-IL----ARKQSGT------ETGGRF---------------GEQEGSLG--------
--------------------------------------------ILHSPLEETTQRPGG-
--------------SSEDQ----------EVAGEK-GVKG----------HPKSQEPSV-
------Q------------------GKDE-P-------------SSEHV---DLP-----
KQAAARKPSQTQ---KSAAAKDE--SR---------------------------------
-----------------------------------------------TAETPEPPIQE--
------------------------------------------------------------
------------------------------------------------------------
------------------KEYETRDLSVQGENRNV----SETPMVR--------VERKGV
RGPEVHQTVGQ-KQ--------------------IEE---------------------KT
QPPAL-------------EEPTEDKKY--HELQESS-------KEKNAGEDSET------
-----------------------------------------HELNSEGGEQK-----DSE
S--------------E-------GA----I-SPGEEARHAEEGTAEALVNSKNAPEAEGT
PGTRE----------RIWE-----------------------------------------
--------------------------------------------LTTLEN-QSGEKNKMT
TKIHDK--LVKEDDGYQ-----------------------------------GEGSEPVA
TQNDERSPETPNSLTAEDGDSNSETS---------------D------------------
--------LFVQGDSQ------------------SQTNPFRGSV---------QGSDSNN
PET---------------------------------------------------------
------------------------------------------------------------
---------------------------------------------QKHLALSEEKRVQEA
A------VLAVR------------------------------------------------
-GEDEQVTEEH----AQEHE-G--------QGSA-----T-TGRGPAVEPRGHSDTQ---
---VFIVRD--ENTKSLEPGIPGAPNAG--ITKQLSVRQLPTKKD---------------
-------------------SRKELKDQSPSTKKEEDGALEAQEDLVKSLDENNAVSQ---
--KTCPA-------------TLEEETESPQQLAGE----QSLSTK-EHDPSVSESGLEER
MQRDQELCLVERGAEHSSPLYEALQEKMLQQTNVTQG--------------------KHQ
N---------------------------------QAQTASVASPE---------IRRNQS
SASLTNDSSDGLVFFIDRQALQ---------------KYIREFLPDEDPTGAQQISAPQA
LEDKQGRPQREELEPQKEASTP----------------------------------K---
-----------------------------Q------------------------------
------------------------------------------------------------
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-------------

----------------MTDLLRSVVTVIDVFYKYTKQDGE-CGTLSKGELKELLEKELHP
VLKNPDD-----------PDTVDVIMHMLDRDHDRRLDFT-----------E-FLL-M--
-I---------------F-K-L-T-M-A-C-NKV----LSK---E-YCK---A-------
SGSKKHRRGHR----------HQEEESETEED--------EE-------DTPG-----HK
SGYRHSSWSEG-EEHGYS---SGHSRGTVKCRHGS-----------------------N-
-SRRLGRQG------------------------NLSSSGNQEGSQ-KRYHRSSC------
---------------------------GHSWS--------G--GKDRHGSSS-VELRERI
N--------------------------KSHI-------------SPSR----ES-----G
EEYESG-------------------SG---------------------------------
--------------------------------------------SNSWERKGHGGLSCGL
ETS--GH-----E-SNST---------QSRIR-EQKLGSS-----CSGSGDSGRRSHACG
YS---------------------------------------------------------N
SSGCGRP---QN---ASSSCQSHRFGGQGNQFSYI-QSGCQSGIKGGQGHGCVSGGQPSG
CGQ-----PESNPCS-QSYSQRGYGA----------------------RENGQ--PQNC-
GGQWRTG--SSQSSCCGQY-----------------------------------------
-----------------------------------------------G-------S----
-GGSQSCSNGQH-----------EYGSC-GRFSNSSS----SNEFS--------------
---KC--------D--QYGSGSSQS------T-SFEQ-----------------------
---------------------------------------HGTGL----S-----------
---QSSG---------FEQHVC---G-----------------SGQTCGQH---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------ESTSSQS-
------------LGYDQ-HGSSSGK-----------------------------------
-----TSGFGQHGSGSGQSSGFGQCG-----------SGSGQSSGFGQHGS---------
V-----------------------------------------------------------
-------------SGQSSGFGQH---G----------S------VSGQSSGFG-------
----------QH-ES-------RSR-----------------------------------
-----------------------QS-S-----Y---------GQHGSGS-----------
------------------------------------------------------------
-SQSSGYGQ--YG---------------------S-------------------------
----------------------------------R-------------------------
---------------------------ETSGFGQH-----GL------------------
------------------GSGQSTG-----------------------------------
------------------------FGQYGSG------SGQSSG-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------FGQH-----------------------
-------GSGSGQSSGFGQHES-RS-G-QSS--------------------YGQHS-SGS
SQSSG-YGQHG-------------------------------------------------
------------------SRQTSGFGQHGSGS----SQS----------T---------G
FGQYG-SGS-GQ--SSGFG-QHV-SGSGQS---SGFGQHESRS--GHS------------
--------------------------------S-Y-------------------------
------------------------------------------------------------
-------G--------------------------QH-GFG--------SS-QSSGY----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------GQHG--------SSSG-QTSGF--GQHEL------
-------SSG------------QSSSFGQHGSGSGQSSGFGQHGS-GSG-QSS-GF---G
QH-ES-RS-GQ-SSY-G-QHSS-GS-SQ-SS----------GYG-QHGSRQ--TSGFGQH
-GSGSSQ---------STGFGQYGSGSGQSAGFGQHGSGSGQSSG--------FG-----
----------QHESRSHQSSYGQHGSGSSQSSGYGQHGSSSGQT-SGFGQHRSSSGQYSG
FGQHGSGSGQSSGFGQHGTGS------------------------GQYSGFGQH------
ESRSHQ------------------SSYGQ---HGSGS------------------S----
----------QSSGYGQHGSS---------SGQTFG------------------------
------------------------------------------------------------
-----FGQ------HRS----GSGQ----S------------------------------
----------------------------SGFG----------------QHGS-------G
S-------GQS-SG----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--FGQ-H-----------ES-GSGKSSGFGQHES-RSSQSN-YGQHGS-GSSQ-SS----
---GYGQHGSS-SG--Q--TTGF-GQ-------------HRS---SS---GQYSGFG-QH
GSGSD---QSSGFGQHGTGSGQSSGFGQYE-SRSR--------QS--SYGQHGSG--SSQ
SSGYGQHGSNSGQTSG------------FGQHRPGSGQSSGFGQYGSGSGQSSGFGQHGS
GTGKSSGFA--------------QHEYRSGQ-SSYGQHGTGSSQSSGCGQHESGSGP---
-------------------TTSFGQHVSGSDNF---------SSSGQHISDSGQSTG---
------------------------------------------------------------
-------FGQYGSGSGQSTGLGQGESQQVESGSTVH------------GRQETTHGQT--
--INTTRH------SQSGQG---------------QSTQTGSRVTRRRR-SSQSENSDSE
VHSKVSH----RHSEHIHTQAGSHYPKSGST-----------------------------
------------------VRRRQGTTHGQR-----------------------GDTTRHG
HSGHGQSTQTGSRTSGRQRFSHSDATDSEVHSGVSHR---------PHSQEQTHSQAGSQ
HGESESTV----------------------------------------------------
-----------------------HERHETTYGQTGE------------------------
------------------------------------------------------------
----ATGHGHSGHGQSTQRGSR--TTGRRGSGHSES-SDSEVHSGGSHRPQSQEQTHGQA
GSQHGESGS--TVHGRHGTTHGQTGDTTRH----AHY---HHGKSTQRGSSTTGRRG-SG
HSESSDSEVHS-----------------------------------------GGSHTHSG
HTHGQSGSQHGESESIIHDRHRITHGQTGDTTRHS---------------------YSGH
EQTTQTGSRTTGRQRTSHSESTDSEVHSGGSHRPHSREHTYGQAGSQHEEPEFTVHERHG
TTHGQI-------------------------------------------------GDTTG
HSHSG---------------HGQSTQRGSRTTGRQRS-----------------------
------------------------------------------------------------
-SHSESSDSEVHSGVSHTHTG-----H-THGQAGSQHGQSESIVPERHGTTHGQTGDTTR
HAHY----HHGLT-------------------------T-QTGSRTTGRRG-SGHSEYSD
SEGY-----------------------------SGVSHTHSGHTHGQARSQH------GE
SES------IVHERHGT-IHGQTGDTTRHAHSGHGQSTQT--GSRTTG-RRSSGHSEYSD
SEGHSGFSQRP-------------------------------------------------
------------------------HSRGHTHGQAGSQHGESESIVDERHGTTHGQTGDTS
GHSQSGHGQSTQSGSST-----------------------------------------TG
RRRSGHSESSDSEVHSGGSHTHSG---HT----------------HSQAR---------S
QHGESESTVHKRHQTTHGQTGDTTEHGHPSHGQT-------IQTGS--------------
-------------------------RTTGRRGSGHSEYSDSEGP--SGVSHTHSGH----
-------------------------------THG-QAGSHYPES----GSSVHERHGTTH
GQTADTTRHGHSGHGQSTQRG------SRTTGRRASG-----HSEYSDSEGHS-GVSH--
---------------THSGH----------------------------------------
--AHGQAGSQHGESG---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------SSVHERHGTTHGQTGDTTRH-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------AHSGH---------------GQSTQRGSRTAGRRGSGHSESSDSEVHSGVSHTH
S-----------------------------------------------------------
-------------------------------------------------GHTYGQARSQH
GESGSAIHGRQGTIHGQTGDTTRHGQSGHGQSTQTG-----SRTTG--------------
------------------------------------------------------------
--------------RQRSSHSESSDSEVHSE-ASPTHSGHTHSQAGS-------------
----------------------RHGQSGSSGHGRQGTTHGQTGDTTRHAHYGYGQSTQRG
---S-------RTTGRRGSGHS------------E-------------------------
-----------------------------------------SSDSEVHSWG---------
-----------------SHT--HSGHIQGQAGSQQRQPG----STVHGRLETTHGQTGDT
TRHGHSGYGQSTQTGSRSS--R---ASHFQSH--SSERQRHGSSQVWK---HGSYGPAE-
-------------------------------YDYGHTGYGPSGG-SRK-SISNSHLSWST
DSTANK--QLSRH-----------------------------------------------
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-------------

------------------------------------------------------------
---KPHD-----------PATVDEVLRLLDEDDSGTVEFK-----------E-FLV-L--
-V---------------F-K-V-A-Q-A-C-FKT----LNESP-EGACG---S-----QE
SRSC-----QP-E----ALQEWRE-GQKSLTEA--GGARRGQLCEE--------------
-------SS-------------------------------------------------HG
HSEQA-----------STVQNQ--------HH----------------------------
-------------------------------SACHDR------------------QVESQ
RQENM-SQESQETGHSEQTQTA-EDNSHQTGE------G--------------Q-----S
ERQS-----QIRGQDKAHQAGT----GTL-------------------------------
--------------------------------------------TQIQ--TDAIQTRGQE
RSRQIESPGTQSQESTYGQTRGT-------------------------------------
------HGQDRSQTSQ-----VVTGGHAQTQ-------------AGSQI----QTVDQ--
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------DRSH--------------QT
GNTSTWSHES--------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------TYGQTRET--GSQNRS
Q---------------TSQIVT---GG--HI----------QTEVGPHIQTV--------
-----------------------------------------D------------------
------------------------------------------------------------
----------------------QDRSLTLSYRSPPM------------------------
--------------------------------------A----------RPEGRSQ----
PS---GN---------R-G-----------------------------------------
---------HVPGG------------------------SQTQTVTKTGAVRQXXXXXXXX
X---------------XX-----------------------XXXXX-X------------
---XXXXXXXXEWVDDHTRES---VFHRQDQSS----LYT--------------------
------------------SVSPAQGEETAQ-------------E-GKQDIT-VKG-----
----------L--------------------------YAYFKSKK---------------
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-------------

----------------MAQLLNSILTVIEVFQKYAKGKGD-CTSLCKKELKQLLLAEFGD
ILRRPND-----------PETVETILSLLDKDRNGHVDFH-----------E-YLL-L--
-V---------------F-Q-L-A-Q-A-C-YHK----LDK---E-LCR---D-------
RTSQ-QEGEHE-G-----KQDHKFPGN-TER---QH----RQSQEGERQ-----------
-DYHCN-QSERQNQDNYQ--DQ-SGRQDRGSS--------------------------SG
QSERQDRDS--HC-GQSGRQDRDSHYGQSGRQDRD---SHYGQSERQDRDSHYGQSGRQD
RDSHYGQSGRQDRDSCYGQSQTQGQDSSSDKKLSH-------------TFGS--GKPKGQ
G--YV-------F-------------ALNQCE------KQ------LQ-----------D
SHYGQS-----------------DKLGQQS------------SCGQ-SGRLG--------
--------EDSS-SHTN----------Q-----QESGSYYEQSERLGQ-ESGHGRRNRQE
LGSHYGQTDRQG------------------------------------------------
------------------------------------------------------------
---------------------------Q--S------S-----------HYGQSDRESQS
-------------------S--HFG-------------------------------QT--
---ER----QGQSSCHGQIDRQG--------------------------------QSSHY
GQTDRQSQGSHYGQTDRQGQ----------------------------------------
-----SSHYGQ-------------------------------TDRQGLSSHM-A--R---
------------------------------------QIDKVRVLTMVRQ---T---D-KA
RVP---------IMARQIDKVR-------VLTMVRQTDKARVPTMARQRDKSRP------
--VIDETSKPMK----MSRPVR--DETSKPMKRIKTVSNDRIGKPMRIKR----GI----
------------------------------------------------------------
------------------------------------------------------------
-----------------------KGPRINSPIGPSKA-----------------------
-----------V------------------------------------------------
------------------------------------------------------------
-----------------------LTEKNST------------------------------
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-------------

----------------MPRLLQNIHEIIEAFGRYAGSEGG-CAALSRGELKRLLEQEFAS
VIVKPHD-----------PATVDEVLRLLDEDKTGTVEFK-----------E-FLV-L--
-V---------------F-K-V-A-Q-A-C-FKT----LSEAP-GGACR---Y-----QE
SESH-----HA-G----SSAELGQ-AQRSGTEG--RQ-----------------------
-----------------------------------------------------------P
QSSQA-----------SGGQGR---------------TGTRIPG----------------
------------------------QDSSSAQGSSHGR------------------QASSQ
RQQTV-RQQTQATGQAEQTPRADGKRHRQTRE------R--------------S-----S
ERWS-----QSSQQ-----TG---------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-ELSGSTSIQTQ---WSTHDQNRRPE-----------------------------SHGQD
WSQ---------------DHQVVTG-----------------------------------
-------HNQAQAGSY--------------------------------------------
------------------------------------------------------------
------------T-----------------------------------------------
------------------------------------------------------------
---QTHSQAVEQGQIP----------------QSGSASIQTPWSTCGQNRGTENNSPDRS
Q---------------AQQVVT---GG--PI----------QTQAGSSTQTV--------
-----------------------------------------P------------------
------------------------------------------------------------
----------------------WR--QTESQAGAQE------------------------
---------------------------------------------------QRQTQ----
TQPNRGHGWIPVSTHEA-VE----------------------------------------
---------PAPG-------------------------GQAQAGVDS-------------
-SH----------PGGQG-----------------------ERVPT--------------
-------VVSEEWVDDHTREV---VIRSEDSGR----LRS--------------------
------------------GRDTAGLQTQQA------------------------------
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-------------

----------------MPRLLRDVLCVIETFHKYASEDSN-QTTLTGRELKQLLQGEFGD
FLQPCV------------LHAVEKNWNLLTIDSNYTISFD-----------E-FVL-V--
-I---------------F-N-L-L-N-L-C-YLD----IQS-----LLS---S-ELRQ--
-ATKP-EKQKPDD------VALQAAT---GG---------GQWTAE---TSPT-------
-----------QQER----------------MLPS----------------------EMA
SSSQLMPEES----------------GAVGNHRVD-PWREAKTHNFPGEASEHNNS----
---KNQHL-------------------------------------------------EGD
-------ERSQEVAQDVPTTEDNEGQ-LKT-K---PMEGSKQTSSPTK-RKG-QNKEIPQ
ESD-ES----AREQSVS------KIRDQF---------------GEQEGNLG--------
--------------------------------------------TQSSPAQEATQRPSE-
-----------------DQ----------EVRIEK-E--K----------HSNTQEPPL-
------Q------------------GEDE-P-------------NSEHA---DMP-----
EQAAARKPSQTQ---KSTDPEDV--CRT----SDNQEPGKDAD------------QTPAE
------------TKN--SGETEDYDR---------------------TSEAQE-------
------------------------------------------------------------
------------------------------------------------------------
------------------KECETKDLQDQSGRRNG----SESSDMR--------DERKER
RGPETHGTAGQ-KE--------------------PDR---------------------KT
RPLVL-------------ETQTQAGKY--QELQGLS-------TSKDAEKGSET------
-----------------------------------------QYPSSEGGDQT-----HPE
L--------------E-------GA----E-VSGEEAEHTEEGTAEAFVNSKNAPAAEGT
LEAKE----------KTRD-----------------------------------------
--------------------------------------------LAPLEK-RSAGENSRV
TKTHDK--PVEEEDGYQ-----------------------------------REDPESPI
TQNDEGSSETPNSLASEEGNSSSKTG---------------E------------------
--------LPMQGDSQ------------------SQGYPHGKSV---------QGGRNNN
PGT---------------------------------------------------------
------------------------------------------------------------
---------------------------------------------QRQGTPGEKNRAQEA
V------VLAVR------------------------------------------------
-GEDIQHTEDQEQPAREKYK-S--------QGSG-----T-KGPGAAVEPSGHPEAQ---
---ESTTRD--ENRKSLEIEITGALDED--FADQLSLMQLLGKGE---------------
-------------------SRNKLKVQGPSSKEEKGRTPEAQGALLERWDEDKSASP---
--QIQLETEE-------PVTL-EEEDESPQELAGGG-NQQNPTKK-EPNSSVSWSSLKKQ
MQRDQEPCSVEKSTVHSSPLYQYPQQKILQETNINQE--------------------EHQ
K---------------------------------QVQIVQASGPG---------LCS---
-VSLTSEISDCSVFFNYSQASQ---------------AYTRGLPPDESPADAQETPAPQA
VEVKQGHPHRERLVPQREASTT----------------------------------K---
-----------------------------E------------------------------
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-------------

----------------MAPLLNSILTVIEVFHEYAKENDD-CTSLGKKELKQLLLKEFQE
ILRRPHD-----------PQTVDTILQLLDRDHDEHIDFN-----------E-FLL-L--
-V---------------F-K-L-A-Q-A-C-YLT----QSK---K-LCR---D-------
KTGSHQERGRE-K-----TRDHHLPEEGMGK---QQ----KQKHRGQRQ-----------
-DSHRGQSER-QDRDSRY--GQ-SERQDRDSR--------------------------YG
QSERQDRDS--RY-GQSERQDRDSHYGQYEGQDED---SHYGQHEGHDHHCHHDHSG-KD
QHSHHGQDERQDHHSHHDQSERQDNTSRC-------------------------------
------------------------------------------------------------
---GQS-----------------KRLGQDS------------HHTN-SSRPG--------
--------QDIH---------------------------SDQSKRRGQ-EAGCGQSER--
------------------------------------------------------------
------------------------------------------QNHGSHY---GQSQRLGQ
ESNCGQTDRQRL---NTGNSHSGRQG-Q--E------Y-----------GCGQTDRQGLD
-------------------S--HCG-------------------------------QS--
---GR----QGLDSHYGQSRGQE--------------------------------LGTQC
GQSGRQGLDSHYGQ----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------SGSQGLDSHYGQSGD---------
------------------------FGQESS-----YGQSGREGLDS------------H-
------------------------------------------------------------
------------------------------------------------------------
-------------------YGQSGRQGLD-------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------SHYGQSGRQGLDSHYGQSGRQGLDSHYGQSGRQGLDSHYGQ
SGR-QGLDSHYGQSGRQGLDSHYGQSGR--------------------------------
----------------QGLD-----------------SHYGQSGRQGLDSHYGQSGRQGL
DSHY--GQSGRQGLDSHYGQSGRQGLDSHYGQSGRQGLDSHYGQYGGFGQDS--------
----------SYGQTHRQGLDTGYGYS-----EVQGQNSQFQNSGR-RG-----------
--Q------------------AEQDLS-RNQDHVSGEDRQGHFHQGLWQP----ERESE-
-----------SRQHKVYSQS--QQERT--LCHKGREWQKDGT-----------------
-------------------EQTGGQAQDRRGCEE--------------------------
------------------------------------------------------------
--------------------------K---------------------------------
------------------------------------------------------------
----KSYQRYDQQTHKEEQSHQ-----------------TRDRQGHEEQGTSSQRQNRQS
CGNE--------------------------------------------------------
------------QSHWT---------------------QDNQTQNRQTRDNEKYHQTRDR
QDHQDC-------SN---------------------------------------------
------------------------------------------------------------
--------------------------------------EQSHQRQDRQTRGEEES-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------SCQ------------------------------------
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-------------

----------------MAQLLSSILTVMKVFQKYANENGD-CTSLCKKELKQLLLAEFGD
VLR RPND-----------PE TVDTILSLLDRDRNGSVDFQ-----------E-YLL-L--
-V---------------F-Q-L-A-Q-A-C-YHK----LDM---G-SCG---D-------
SANQ-QEEGQE-G-----AQDHKSPRN-SER---QH----RHRHDEDKQ-----------
-DSHHD-QSEGQDRD---------------SH--------------------------HG
QSQRHDSHS--RH-GQSERQDRDSHHGQT---------------DRQDQHSHCGQSGRQD
RASSLDHSERQ------------GQDSGYDQKLSH-------------KSGS--GQPQRQ
A--YL-------F-------------ALTQCE------KP------VQ-----------D
SHYNQ-------------------------------------------------------
---------------SQ---------------------------RLGQ-Q----------
------------------------------------------------------------
----------------------SGCGQSRRLGQDSCSSQIAHQESGSHY---GQSGSLGQ
ESGCGQRDRHG---LDSHYGQTDRQG----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------LGFQCGQTDR---------
------QTQHSH----YGQTDT--HGQSSH-----YGQTDRKGQSYQYSQTGRQGQSYQ-
------------------------------------------------------------
------------------------------------------------------------
-------------------Y----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------GQTDRQDRSYTYGQTDRQGLGSQYGQTDRQGQSYQYGQSQ--------------
----------------R---------G---ETERQGQNRYFQGSQG-TG-----------
--R-NSCAEQSGRVRRLSQQAQGQ---------------GGQNSHQAWEGQ--AEEDAQ-
-----------HHQHKLLAHF--QQEKP--LCHKGRDWQSCGS-----------------
-------------------EGAHRQAQTQQGCSE--------------------------
------------------------------------------------------------
--------------------------G---------------------------------
------------------------------------------------------------
----TSH--------EREQGRQ-----------------SCGRQSQ----ETCETQDRQT
HEEEQNHQRGNRQTHDHEWNSQ--------------------------------------
--RRDRQTHHDEQNC-Q-------------------------R-----------------
------------------------------------------------------------
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-------------

----------------MPQLLRNIHGLIEAFRRYATSEGG-CTALTRREMKRLLEHELAD
VIVKPHD-----------PATVDEVLRLLDEDNTGTVEFK-----------E-FLV-L--
-V---------------F-K-I-A-Q-A-C-FKT----LNESP-SGPCR---S-----QE
SESC-----HP-R----SSTELEQ-GRRSGTEV--GRDGRGQHHEG--------------
-------SG-------------------------------------------------CG
QSDQA-----------SRGQGR---------------VGTHTQG----------------
------------------------QESYSIQVSNRGR------------------QAESQ
RQEMV-SQWTRVIRPVEQTPRIEDKSQ--TRE------R--------------R-----S
ERQS-----WTSQQ-----TDETM-TGTT-------------------------------
--------------------------------------------TQTKT--G--------
--------ASQTQGSTCSQNRGT----------------K--------------------
-----TYVQDRSQASQ------ATTGHNQAQ-------------AESYTQTQTQMVEQSR
SQQTGNTSIQTQ---ESIYDQTRGTE-----------------------------PHGQD
RSQ---------------AGQAATG-----------------------------------
-------HFQIQMGPH--------------------------------------------
------------------------------------------------------------
------------T-----------------------------------------------
------------------------------------------------------------
---QTHTQIVEQSWNQ----------------QTGNTSIQTQGSTCGQNRGTETHGQDWS
Q---------------AGQAAT----G--HF----------QTQAGPYSQTV--------
-----------------------------------------E------------------
------------------------------------------------------------
----------------------QDRSRSASQKGVQE------------------------
---------------------------------------------------QGQTQ----
MQSGMGQRWAQVSNYEV-GE----------------------------------------
---------PVLG-------------------------GQVQTRTRTVME----------
--S----------QGRQE-----------------------ERVPT--------------
-------VVRDEWVDDHTREL---VIRSQDPGS----LHS--------------------
------------------GSPSAQIQGTAQ------------ME-EKKGIV-ATG-----
----------L--------------------------YSYLKSGKP--------------
------------------------------------------------------------
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-------------

----------------MPQLLQNIHGIIEAFGCYARSEGG-CKVLTRGELKRLLEHELAD
VIVNPHD-----------PSTVDEVLRLLDEDNTGTVEFK-----------E-FLV-L--
-V---------------F-K-V-A-R-A-C-FKT----LSESS-RDACM---S-----DK
SERC-----SP-G----SEKELEQ-GQRGGTGA--GRGGAEQCFED--------------
-------SG-------------------------------------------------RG
QRDQA-----------SKTQVR---------------VGTHTQS----------------
------------------------QDSYPTQVSSHDR------------------EVESQ
RQEI-ESQQTQVTGQEEQTPRREDQSW--ARE------R--------------R-----S
ERQS-----QISQQ-----KEETI-ARPT-------------------------------
--------------------------------------------TQTQE--S--------
--------AFQTQGST-----------------------C--------------------
-----GHSQDRSQADQ------AATQHYQTQ-------------AGSHTQIHTPTVEQGW
RRQTGSDSIQTQ---GSTYDQNPETE-----------------------------TQGQD
RNQ---------------AGQAAKE-----------------------------------
-------HYQEQ------------------------------------------------
------------------------------------------------------------
------------T-----------------------------------------------
------------------------------------------------------------
---CTHTTMTQQGRSQ----------------QAENSSVQTHGSIYDQNRRTEIHGQDSS
H---------------AGQIGT----G--HF----------QT------QTL--------
-----------------------------------------E------------------
------------------------------------------------------------
----------------------HDRSQSESQVRDPE------------------------
---------------------------------------------------KRQTQ----
IQSGMEQSYTPVSNYET-GE----------------------------------------
---------PILG-------------------------GQVQTKTSTVKERPDWNSGHP-
-SP----------KGGQG-----------------------ERVPT--------------
-------VIRDEWVNDHTREI---VICSQDPGS----LHS--------------------
------------------LAPPAQGQEAAQ------------ME-EKKGIT-AKG-----
----------Q--------------------------YSFLKTNQP--------------
------------------------------------------------------------
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-------------

----------------MPQLLQNIHGIIEAFGCYARSEGG-CKVLTRQELKRLLEHEFAD
VIVKPHD-----------PATVDEVLRLLDEDNTGTVEFK-----------E-FLV-L--
-V---------------F-K-V-A-R-A-C-FKT----LNESP-KGACI---S-----DK
SEGC-----YS-G----SSKELEQ-RQRGGAEV--AKDGAAQHCED--------------
-------SS-------------------------------------------------CG
QRDQA-----------SRGQDR---------------VGTHTQN----------------
------------------------QDSYPTQVSSHDR------------------QTESQ
TQEMI-SQQTQVTGQVEQTPRTEDKSW--TRQ------K--------------R-----S
ERQP-----QSSQQ-----TDEIT-TGST-------------------------------
--------------------------------------------AQTQA--G--------
--------NFYTQGSTCDYNRGT----------------N--------------------
-----SHHQDRSHADR------ASTQHYQTQ-------------AGSHTQIHTQMVEQAW
GQQTGSDSIQTQ---GSIYDQSTETV-----------------------------IHGQD
RNQ---------------ASQSVKE-----------------------------------
-------HHQAQGESY--------------------------------------------
------------------------------------------------------------
------------I-----------------------------------------------
------------------------------------------------------------
---QTHTQTMEQGRSQ----------------QAENSSTQTHGSMYGQNRETEIHGLESS
Q---------------AEQVGT----R--HY----------QTQAGSYTQTL--------
-----------------------------------------E------------------
------------------------------------------------------------
----------------------HDGSQSAHKFVAQE------------------------
---------------------------------------------------KERTQ----
TKPCMGQSWTPVSNYET-EE----------------------------------------
---------SVIG-------------------------GQVQTETDTIIE------NHP-
-SP----------TARQV-----------------------ERVPT--------------
-------VVREEWVNDHTREI---VIRSQDPGS----LHS--------------------
------------------GTPSAQGQDIPQ------------M--EKKGIT-AKG-----
----------L--------------------------YTYLKTEQP--------------
------------------------------------------------------------
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-------------

----------------MPQLLRNINGIIEAFERYARTEGD-CAVLSRGELKRLLEHEFAD
VIVKPHD-----------PATVDEVLRLLDEDDTGTVEFK-----------E-FLV-L--
-V---------------F-K-V-A-Q-A-C-FKT----LSESP-EGACG---S-----QE
SGSH-----PS-G----ASQELGE-GRRSSTEV--GRVGKGQRHEG--------------
-------SS-------------------------------------------------GG
QSEQA-----------SRGQGG---------------TGTQTQG----------------
------------------------QDISSTQVSDHDK------------------QSESQ
RQQRE-SQQTQSRGHVEQPQRVGEDNGPQTRE------L--------------G-----S
ERQS-----QTREQDRAHQTSETM-SGTI-------------------------------
--------------------------------------------TQTQT--GATQTMEQE
RSHQTGSTGTQPQESMYGQTRRT----------------E--------------------
-----THSQDRSQTSQ-----VVTGGHIQTQ-------------AGRQAGSHTQTVEQDR
SQQTGSTGTQPR---ESTYGQTRGTE-----------------------------THSQD
RSQ---------------TSQVVTRG----------------------------------
-------HIQTQAGA-----TQT--------------VEQDRSH--------------QT
GSTSTQPQESTYGQTRGAEI----------------------------HTQHRSQTSQVV
TRGHIQTQAR--------------------------------------------------
------------------------------------------------------------
----SHTQTVEQDRSH----------------QTGSTSTQPQESTCGQTRGTETHSQDRS
Q---------------TSQVET---GG--HT----------QTQAGSHTQTV--------
-----------------------------------------E------------------
------------------------------------------------------------
----------------------QDRNQTSSHIGSRE------------------------
---------------------------------------------------QGQTQ----
TQSGSGQRRTQVSNYEA-GE----------------------------------------
---------TVLG-------------------------GQAQTGAS----------THSS
CSV----------TGGQR-----------------------EREPT--------------
-------VVNQEWVDDQTRTI---VIQRQDQGS----VHT--------------------
------------------SVPSAQGQEAAQ------------PE-GKRGIT-ARG-----
----------L--------------------------YSYFKTTKP--------------
------------------------------------------------------------
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-------------

----------------MPKLLQGIITVIDVFYQYATQHGE-YDMLNKAELKELLENEFHQ
ILKNPND-----------PDTVDIILQSLDQDHNKKVDFM-----------E-YLL-M--
-I---------------F-K-L-V-R-A-H-NKI----ISK---D-YCQ---A-------
SGSKLRDDSHQ----------HQEEQEETEKE--------D----------KW-----QE
SSSSHSSWSAG-ENDSYS---RNV-RG---------------------------------
------------------------------------------------------------
----------------------------------------S--ITHWPESIS-RSL----
----------------------------------------------------NF------
---QRD-------------------FSGEN------------------------------
----------------------------------------NSC-SG-------Q---SS-
---RYG------------------------------------------------------
-------------QHES-------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
-----------------------------GSQQSPR-QG-QH-GSL-SGQ-SPT-YG-QR
-ESG-YK-QS-SSS-GP-HG-SG-SQQSSA-FG---QQ---------ES-----------
---TS---------GQ-S---------SGY-NQ-H-----GS------------------
-------------------GSG-HS-----------------------------------
------------------------SS-HGQ-------HGC-TS----------------G
-Q-SS--SFG-Q----E-G-SS-TGQ-SSSY---GHK-GSG-S-----------------
-------SQ-SSGY-GR-------------------------------------------
-----------------------------H---GAG-S--GQS-P-S-H-----------
-------------G----RH---GSG-SGRSSNCGP------------------------
-------HG-SG------------------------------------------------
------------------------SG------------------QS----------SGV-
GEH--ES--SSG-------QSS-SY-TQH-GS----G-SG---------H----SSS-YG
--QHG-SR-SGQ------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------S-S--R-----------G-E-QH-G
-S-S----------S--GSS------------------------SSY--GRHGS------
-------GSH------------QSSGHGRHGSGSG------------QSPSPSRGR----
---------------------------------------------H-GSGSGQSSSYNPH
-GSGSGR---------SSSRGPYGSGSGHSSGLGQHESRSGQSS--------GYG-----
----------QH------------GSSSGHSFSHGQHGSTSGQS-SSCGQHGASSGQSSS
HGQHGSGSSR--------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
----------------------SSGYGRQG-SGSG--------QSP-SRGRHGSG--SGH
SSSYGQHGSGSGRSSS-----------R-GPHESGSGHSSGFGQHQSGSGQSSGYSQHGS
GSGHSSSHG--------------QHGSTSGQSSSFGQEGSSTGQSSSYGHQGSGSS----
------------------QSSGYGRHGAGSGQS---------PSRGRHGSGSGRSPSCGP
------------------------------------------------------------
-------------------------------------HGSGSGQSSGFGQHESSSGQS--
--SSYTQHGS--------------------------------------------------
------------------------------------------------------------
----------GSGH--SSSYGQHGSRSGQ-------------------------------
------------------------SSRGEQHGSSSGSSSSYGRHGSGSHQSSGHGRHGSG
SGQSPSPSRGRHGS----------------------------------------------
-------------------------------------------GSGQSSSYNPHGSGSGR
S-----S-----------------------------------------------------
-----------------SRGPY--GS----------------------------------
------------------------------------------------------------
------GSGHS------------------------------------------SGLGQHE
SRSGQS-SGYGQHGSSSG--HSFSHGQHGSTSGQS-SSCGQHGASSGQSSSHGQ------
--------------------------H-----------------GSGS--SRSSGYGRQG
SGSGQSPSRG--------------------------------------------------
-----------------------------RHGSGSGHSSSYGQH----------------
------------------------------------------------------------
----------------------------GSGSGRSS-------SRGPHESGSGHSSGF--
-GQH----------------------------------------------QSGSGQSSGY
SQHG--------------------------------------SGSGHSSS----------
----------------------------H-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------GQHGSTSGQSSSFGQEGSSTGQSSSYGHQGSGSSQSSGYGR-----
--------H-GAGSGQSP----------------SR------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---GRHG-----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------SGSGRSP
SC-------------GPHGSGSGQSSG--FGQ---------HESSSGQSS----------
-----------------------SYTQHGS--------G-SGHSSSYGQHGSRSGQSSRG
EQHGSSSG-------------------------------------------------SSS
S-----------------------------YGRHGS-GSHQSSG----------------
----------HGRHGSGSGQSP--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------SPSRGRHGSGSGQSSSYNPHGSGS-
-------GRS-----SSRGPYGSGSGHSSGLGQHESRSGQSSGYGQHGSSSG--------
-----------------------------H------------------------------
----SFSHGQHGSTSGQSSSCGQH-GASSGQSSSHGQHGSGSSRSSGYGRQ---------
----------------------------------GSGSG---------------------
------------------------------------------------------------
--------QSPSRGRHGSGSGHSSSYGQHGSGS-----------------GRSSSRGPHE
SGSGH-----------------SSGFGQHQSGSGQSSGYSQH------------------
--GSGS-------GHS------SSH------GQHGST-----------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------SGQSSSFGQEGSSTGQSSSYGHQG--------
-------------------------------SG-------------SSQSSGYGRHGAGS
GQSPSRGRHGSGSGRSPSCGPHGSGSGQSSGFGQHESSSGQSSSYTQHGS-GSGHSSSYG
QHGSRSGQSSRGEQHGSS---------------------SGSSSSYGRHGSGSHQSSGHG
RHGSGSGQSPSPSRGRHGSGSGQSSSYNPHGSGSGRSSSRGPYGSGSG---HSSGLGQHE
SRSGQSSGYGQH------GSSSGHSFSHGQHGSTS--GQSSSCGQHGASSGQS-SSHGQH
GSGSSRSSGYGRQGSGSGQS--PS-------------------RGRHGSGSGHSSSYGQH
GSGSGRSSSRGPHES---GSGHSSGFGQHQSGSGQSSGYSQHGSGS--------------
--------------------GHSSSHGQHGSTSGQSSSFGQEGSSTG------QSSSYGH
QGSGSS--QSSGYGRHGAG----SGQS---------------PSRGRHGSGSGRSPSCGP
HGSGSGQSSGFGQHESSSGQSSSYTQHGSG----SGHSSSY--------------GQHGS
RSGQ--------------------------SSRGEQHGSSSGSSS--------SY-----
G-------------RHGS-------------------GSHQSSGHGRHGSGSGQSPSPSR
GRHGSGSGQS--------------------------------------------------
-----------------------------------------------SSCGQ---H-GS-
--GSGQSS-GYIQHGRVSGEGGYSYS-KEGSNHE----GESSGSDFLSFDSRTLPYEYIQ
KQRCYFR-----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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-------------

----------------MPQLLQNINGIIEAFRRYARTEGN-CTALTRGELKRLLEQEFAD
VIVKPHD-----------PATVDEVLRLLDEDHTGTVEFK-----------E-FLV-L--
-V---------------F-K-V-A-Q-A-C-FKT----LSESA-EGACG---S-----QE
SGSL-----HS-G----ASQELGE-GQRSGTEV--GRAGKGQHYEG--------------
-------SS-------------------------------------------------HR
QSQQG-----------SRGQNR---------------PGVQTQG----------------
------------------------QATGSAWVSSYDR------------------QAESQ
SQERI-SPQIQLSGQTEQTQKAGEGKRNQTTE------M--------------R-----P
ERQP-----QTREQDRAHQTGETV-TGSG-------------------------------
--------------------------------------------TQTQA--GATQTVEQD
SSHQTGRTSKQTQEATNDQNRGT----------------E--------------------
-----THGQGRSQTSQ-----AVTGGHAQIQ-------------AG--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------THT-----------------------------------------------
------------------------------------------------------------
---QTPTQTVEQDSSH----------------QTGSTSTQTQESTNGQNRGTEIHGQGRS
Q---------------TSQAVT---GG--HT----------QIQAGSHTETV--------
-----------------------------------------E------------------
------------------------------------------------------------
----------------------QDRSQTVSHGGARE------------------------
---------------------------------------------------QGQTQ----
TQPGSGQRWMQVSNPEA-GE----------------------------------------
---------TVPG-------------------------GQAQTGASTESGRQEWSSTHPR
RCV----------TEGQG-----------------------DRQPT--------------
-------VVGEEWVDDHSRET---VILRLDQGN----LHT--------------------
------------------SVSSAQGQDAAQ------------SE-EKRGIT-ARE-----
----------L--------------------------YSYLRSTKP--------------
------------------------------------------------------------
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-------------

----------------MSKLLRGIFCVIETFHKYASKDGDNKARLTLRELRQLLEGEIGN
FLQPQV------------FHAVERKLDLLNIDRDGTISFE-----------E-FLL-A--
-I---------------F-S-L-L-N-L-F-YFD----I-S-----LLS---S-EPRL--
-MSKS-EK--MDD------VDLLATT---RS---------SQKVVG---VGPT-------
-----------QERL----------------VFAS----------------------EIT
SSAQPSHEEG----------------EMDEQNRTS-PLEDIKTHNLPGEVSEPNDP----
---ENQHP-------------------------------------------------EED
---------SQEVAQDVPATESDGVQ-FKRNT---PAEASKQNDSSTQ--------VIPK
EGG-KV----VRRQSDT------KVSDHM-------------------------------
-----------------------------------------------------AQRPSE-
-----------------DE------------------EHK----------HSTTQDPLP-
------P------------------KEDK-A-------------TLEHA---DLP-----
IEAASGKPSQTQ---KFFELMDD--ARI----SETGEPGKDAG------------RTPPE
------------TTN--LKDPKADRR---------------------TSEIQGLPEQE--
------------------------------------------------------------
------------------------------------------------------------
------------------RKHETRNQSAQSGSRDD----SETSSRG--------K-----
------WEEEQ-KE--------------------HER---------------------KT
EPPAP-------------EAQTQNEKC--QEFSRSW-------RENGAKKGSGT------
-----------------------------------------QGLSSEKGNEN-----LPE
I--------------K-------EE----Y-VSEEEARHSEKDIADAFLSNKESPTAEET
RGTRE----------RSQE-----------------------------------------
--------------------------------------------LAPLEK-QSQGKSHRA
TKTHDK--VARKEDHSE-----------------------------------GEDPELPV
TQNDEGPCESPSGLAPEIGNSSSDSS---------------E------------------
--------LQVPGDLQ------------------SQVDTHGDAK---------QGSDDNN
SDP---------------------------------------------------------
------------------------------------------------------------
---------------------------------------------RKQRASGDSSRVQEA
V------ELLVQ------------------------------------------------
--EGRGLPEEQGQSAREK----------------------QDGIGAAVEPSEEGEVQ---
---ESTAGG--ENRKSPEAESSGAQ-----------------------------------
------------------------------------------------------------
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-------------

----------------MPRLLRDVLCVIETFHKYASEDSN-GATLTGRELKQLLQGEFGD
FFQPCV------------LYAVEKNSDLLNIDNNGIISFD-----------E-FVL-A--
-I---------------F-N-L-L-N-L-C-YLD----IQL-----LLS---S-ELRQ--
-VTKP-EKEKPDD------VDLQATT---GD---------GQWTAG---TSPT-------
-----------QEER----------------MLPS----------------------GMA
SLSQLIPEES----------------GAVGNNRVD-PWREAKTHNFPGEASEYNDP----
---KNQHL-------------------------------------------------EGD
-------EQIQEVAQDVQTTEDNEGQ-LKANK---PMARSKQTSSPTK-RKG-QDKKISR
EGD-EP----VREQSVS------KIRDRF---------------GEQEGNLE--------
--------------------------------------------PQNSPPEEETQRPSE-
-----------------DQ----------EVRTEK-E--K----------YSNTQEPPL-
------Q------------------GEDE-P-------------SSERA---DLP-----
EQAAARTLSQTQ---KSTDPEDV--CTT----FDTQEPGKDAD------------QTPAE
------------TTN--SGEPEDYGR---------------------TSETQE-------
------------------------------------------------------------
------------------------------------------------------------
------------------KESETKDLPVQGGSRNG----SETPDMR--------DERKKR
RGSETHETAGQ-KE--------------------RDR---------------------KT
QPLVL-------------ETQTQDGQY--QEFQGLS-------KSKDPEKDSET------
-----------------------------------------QYLSSEGGDQT-----HPE
L--------------E-------GT----A-VSGGEAEHTKEGTTEAFVNRKNAPAAART
LGARE----------STQD-----------------------------------------
--------------------------------------------LAPLEK-QSAGENSRA
TKTHDK--PVEEEDGYQ-----------------------------------GEDSESPF
TQNDEGSSETPSSLASEEDNSSSETG---------------E------------------
--------LPMQGDSK------------------SQGDPHGESV---------QGGHNNN
PDT---------------------------------------------------------
------------------------------------------------------------
---------------------------------------------QRQGTPGEKNRAQEA
V------VPAVR------------------------------------------------
-GEDVQLTDDQEQPSRGEHK-Y--------QGPG-----T-KGPGAAVEPSGHPEAQ---
---ESTAGD--KNRKSLEIEITGTLDED--FTDQLSLMQLPGKGD---------------
-------------------RRNELKVQGPSSKEEKGRATEAQNTMLKSLDEDNSASH---
--KIQLETKE-------TVTS-EEEDESPQELAGEGGDQKSPAKK-EDNSSVPWPSLENQ
VQRDQEPCSVERGAIHSSPLYQYLQKKILQQTNITQE--------------------DHQ
K---------------------------------QVQIAQASGPE---------LCS---
-VSLTSETSDFSVFFNYSQASQ---------------PYTRGLPLDETPAGA---PAPQA
LEDKQGHPQRKRLVPQREASTT----------------------------------K---
-----------------------------Q------------------------------
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-------------

----------------MPQLLRNINGIIEAFRRYARTEGT-CTALTRGELKRLLEQEFAD
VIVKPHD-----------PATVDEVLRLLDEDHTGTVEFK-----------E-FLV-L--
-V---------------F-K-V-A-Q-A-C-FKT----LSESP-ERACS---S-----QE
SGSL-----HS-G----AWQELSE-GQREGTEV--GRAGKGQHYEG--------------
-------SS-------------------------------------------------HG
QSEQP-----------SRGQNR---------------PGAQTQG----------------
------------------------QATGSAWVSSYDR------------------QAESQ
SQERT-SPQTQRSRHTEQTQRAGEGQRHQTTE------M--------------R-----P
ERQP-----QTREQDRAHQTGETV-TGSG-------------------------------
--------------------------------------------TQTQA--GATQTVEQD
SSHQTGRTSTQTQEATNDQNRGT----------------E--------------------
-----IHGQGRSQTNQ-----AVTGGHAQIQ-------------A---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------GTHT-----------------------------------------------
------------------------------------------------------------
---QTPTQTAEQDSSH----------------QTESTSTQTQEATNDQNRGTEIHGQGRS
Q---------------TSQAMT---GG--HA----------QTQAGSHTQTV--------
-----------------------------------------G------------------
------------------------------------------------------------
----------------------QDTSQTVSHGGSGE------------------------
---------------------------------------------------QGQTQ----
TQPGSGQKWTQVSNPEA-GE----------------------------------------
---------TVPG-------------------------GQTQTGASTESGRQEWSSTHPR
HYV----------TEGQG-----------------------DIQPT--------------
-------VVGEEWVDDHSRET---AIFRLDQGN----LHT--------------------
------------------SVSSAQGQDAAQ------------PE-EKQGIT-ARE-----
----------L--------------------------YSYLRSNKP--------------
------------------------------------------------------------
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-------------

----------------MTNLLRSVVTVIDTFYKYTKQDGE-CGTLSKDELKELLEKEFRP
ILKNPDD-----------PDTVDVIMHILDRDHDRRLDFT-----------E-FLL-M--
-V---------------F-K-L-A-M-A-C-NKV----LSK---E-YCK---A-------
SGSKKHRHSHR----------HQEEESETEGE--------EE-------DASG-----QN
SGYRYSSWSEG-EEHGYS---SEGSRGTPKHRHES-----------------------G-
-SRRLRRQG------------------------GLSSSENQKRSG-KRHHGSSS------
---------------------------GYSWS--------N--GKERHGSSS-EELEASY
A-----------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------RQKH-------
-------------------------------------G-----SSSKGSEDGGRESHACG
SS---------------------------------------------------------N
SGGCGRQ---KN---TSSSCQAGRFGEQGNQSSYT-QSGYQSGSS-GEGHRCISGGWASG
Q--------------------KGYGS----------------------RTCGQ--PQNC-
GGQQGTG--SCQSSCCGQY-----------------------------------------
-----------------------------------------------G-------S----
-GVSQSSTYGQH-----------GSGSC-GYSSNSHQKRCGSNETS--------------
---KC--------G--QRRSSSGQS-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------SGFGQHE-----------SGSGQYSGFGHC-----------
------------------------------------------------------------
--------------------------G----------C------GSGQSSGFG-------
----------HH-ES-------TSG-----------------------------------
-----------------------QS-C-----Y---------GQHGSGS-----------
------------------------------------------------------------
-CQYSGAGQ--YG---------------------S-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------GSAQSSGFGHQKS-IS-G-QST-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------C-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------VQHGSGSGQSSSFGQPGS-SSG-QSS-GF---E
HH-ER-RS-QQ-SGY-G-HHEL-GS-GQ-SS----------GFG-QHGST----------
--------------------------SNQSSGFGQHRSGSCQSSG--------FG-----
----------HHEIGSDQSSSD--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------SERHS-EVSQ-RH----
SRSAHGQAGSQ-HG--ESGTTVR-GR-------------HGT---AHGQLGDTTRHG-HS
RQGQS-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------TRSGSRQRHSGSTHGQAGSQHGESGATVR------------GRHRTAHGQS--
--GDTTRH------GHSRQ-----------------------------------------
-----------SHSGSTHGQAGSQHGESGTT-----------------------------
------------------VRGRHRTAHGQS-----------------------GDTSRHD
HSSQGQSTWSGSSQERRQGSSHSEATDSGRHSHVSQS---------HSGS--THGQAGSQ
HGESGTTV----------------------------------------------------
-----------------------RGRHGTAHGQLGDTTRHGHSRH---------------
------------------------------------------------------------
----------------------------------------------------SGSTHGQA
GSQHGESGA--TVRGRHRTAHGQSGDTTRH----GHS---RQGQSTRSGS----------
------------------------------------------------------SQSHSG
STHGQAGSQHGESGTTVRGRHGTAHGQSGDTSRHD---------------------HSRQ
GQSTWRG-----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------RQG
SSHSEATDSGRHSQVSQSHSG-----S-THGQAGSQHGESGTTVRGRHGTAHGQSGNTTG
HVHS----GHGQSTWSNRQSSHTHAHFGKSHSTSQISGRQRHRSDQAWRHGSYGSAEYDY
GQSGYGPSSGSRTSSHNSSPFSSPVPS---------------------------------
-----RRSRNTGQRQGS-HHEQSRDSSRHSGTRHGQPSTGS----GGSRHRESSVSQASD
SEGHSEDSGRQ-------------------------------------------------
---------------------------------SVTTHGRPGSSSRNQHGSSQGQTGDSS
RHSESHQGRHNSGRQSVT---------------------------------------THG
RPGSS------SRNQHGSSHGQTG------------------------DSSRHSESHQRS
HSEAVHESSRNQHGSSHGQSGDSSRHSESHQERHS-----ESVHGRSGSSTGQRQGSHHE
QSRDSSRHSGT--RHGQTS---AESGNGRHRESSVSQASDSEGH--TRDSGRHSETT---
-----HGRPGSSSRN--------------------QHGSSQGQTGDSSRYSSRNQHGSVH
GQTRDSPRHSESHQERHSESV------HGSSRNQHGS----------SQGQTGSGTGHGH
ASAGSGINRHRESSVSQASDREGHA-----------------------------------
RDSGRQSVTTHGRPG---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------SSSRNQHVSSHGQIGDSSSHSET----------------------------
------------------------------------------------------------
-----------------------------------------NQRSGSSTGQRQGSHHEQS
RDSSRHSGTGH---------------GQTS-AGSGSSRHRESSVSQASDSEGHSEDSGRQ
N-----------------------------------------------------------
--------------------------------------------------------VTTH
GRPGSSSRNQHGSSQGQTGDSSRYSASHQGRHSESV-----HERSTSRTG----QR---Q
GSHHE-QSRDS-------SRQSGTGHGH--------------------------------
-----ASAGSGINRHRESSVSQASDSEGHSE-DSGRQNV-------T-------------
----------------------THGRPGSSSSNQHGSSHGQTGDSSRHSESHQGSHGESV
HQRSG------SSTGQRQGSHHE-----------Q-------------------------
-----------------------------------------SRDSSRHSGT---------
-----------------GH----------------GETS---------------------
TGSGSSRHRESSVSQSSDS--K--GHSRGSGHHFSSKDQSFSFAQNWSDSN-ESLGNRQH
KKKPSQSPSKEHHG----FISGSCGGQDHWSNSSEPAGYGHGYGSGQP-S----QQRWHE
SNSSEVSSYGQHRSGSEQPSSSIQHGFGS-----G-QSSGYGQHRSSSG-Q---------
-------SS-GFSHHGTGIGQSS-------------SYEQ---H-----------SATSR
QPPNCSQHGPSL-----------GHSTSCGQYGSGSGQSSSCGQHSTGSSQSLNHGQHRS
ESSQTSSYGQQRTVSGQSSGYRQHRSGSGESSGFNQHRTGLGQSS-----------SYEQ
HGSTSGQSQNCGQHGSNL------------------------------------GQSSSY
GQHGSSQ--YSGHSQHRSGSSQSSGHSRHG---SGSGQS-----------A--------S
FGQHGS------------------STRESSGFGQHGSGLSQSSSYGQHGSTSRQSSSCGQ
QRSNLGQSSSYGQHGSS---------------SSQSSGHSQHGSGSGQSSSCGQHGSSSR
ESSGFGQHGSGLGQSSSYGQQGSTSGQSSSCGQEGSNLGQSSSYGQHGSSQHGSSQSSRN
SQHR--------SGSSQSSSFGQHGFSSRESSG------------F---------GQHGS
GLGQSSSYGQQGSTSGQSSSCGQE-GSNLGQSSSYGQHGSSQHGSSQSSRN---------
------S-----------------------------------------------------
----------------------QHRSG---SSQSS----------------------SFG
QHGFSSRES-SGFGQHGSGLGQSSSYGQHGSTSGQSS----SCGQQRSNLGQSSSYGQHG
SSQYGSSQSY-SHSRHRSGSSQSSGHSQQGLGSSQSSSFG--------------------
------------------------------------------------------------
------QHGSSSRESSGFGQHGSGLG-----------------QSSSFGQHGSTSGQSSG
CGQ-QRSNLGQSSSYGQHGSSQYS--SSQYSQYSGHSRHRSGS----S---QSSGHSRHG
SGSSQSSSCGQHGFSSRESSGFGQHGSGLGQSSSYGQHGSTSGQSSSCGQQR-SNLGQ--
-----------------------SSSYGQHGSSQYGSSQ----------SYSHSRHRSGS
SQSSGHSQQGLGSGQSSSFGQHGSSSRESSGFGQHSSGLGQSSSYGQHGS-TSGQ-----
--------SSSCGQQGSN---------------------LGQSSSYGQHGSS--------
-------QYGS------------------------------------SQSYSHSRHR---
SGSSQSSGHSRH------GSGSGRSSSFGQRGSSS--RESSGFGQHGPG-LGQSSSYGQH
GSTSGQSSSC-----------------------------------------------SQQ
GSNLGQSSSYGQCGSSQYGSSQSSGCRQHGSVSGQSSSFG----QHGSSSR---------
---------------------ESSGF-------GQHGSGL------------GQSSTYGH
HGS----------TS---GQS------SSCGQNISGSGQ--SSSYGQC------------
--------------GSGSDQSSRYSQ-----------------QRSGLG-------Q---
--SSGHVQCGT-----------------------------------GP--SQSSSCS---
QFG---SGW-SQSSSY--GQ-HRSGSGQCSTQSQHGSGLGQCSTSEQHGPGS--------
------------------------------------------------------------
-------------------------------------------------CHS-SSSEQCG
SGSGQCSSYDQYEL-QDNRQGGYYYQREGGHDGGRD-----TNSSFYKLRTSTPLYEYVQ
EQRC--------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------

----------------MPQLLNSILSVIRVFQNYAKENGD-CTSLCKTELKQLLLTEFGD
ILRKPND-----------PETVENILNHLDRDRNGCVDFH-----------E-YLV-L--
-V---------------F-Q-L-V-Q-A-C-HHK----LDN---K-TYG---D-------
RTSQ-QEKGHE-V-----TQDHKFPGG-TGR---QH----QQTHVGKRQ-----------
-HSHDS-QPGRQSHDVQH--DQ-SEKQ---------------------------------
-------D-------------------------RD---FHYGQPKRQDRDSHHGQFERQD
NDFFYDQFERQDNSSHH-------------------------------------------
----------------------------------------------GQ-----------S
EKQDRH------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------FHSGQSES------------QDRNSHH---GQSEKQDG
DSHHCQSKRQD---RDSHHDQSERQD-K--H------Y-----------SSDQSKRQSQA
-------------------S--SS------------------------------------
------------------------------------------------------------
GR--------------RLSH----------------------------------------
-----KSS-------------------------------------------S-G--QQKE
QGH---------------IFVLN-------------QFE---------------------
--------------------------------------------------K---------
------PAQEPH----YAHSAK--VGQQSH-----YGQSGRLTQDPC-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------SNQTNQQES-----GFYYGQSGRLN-------------
-------------QKSGYGQTDTQGQV------------CHHGQTDIQGQSC--------
----------HYSQTDRQVQSCHYGHSQAGEAQIQGQNRYFQGNGE-TR-----------
--R-DSYVEQSGKSRRLSQQTPEQEVN-QNQTQGFQSREEQHSSHYASKP----EEDSQ-
-----------YHQHKLLSQI--QQERP--LYHKGSDRQSGSS-----------------
-------------------EQSHRQVQPRQTQDK--------------------------
------------------------------------------------------------
--------------------------G---------------------------------
------------------------------------------------------------
----QIHQA------EEEQGCQ-----------------SWGGHSHDGQESAWEAQDRQT
HEEEQSHQTKDRQKYEDKQNHH--------------------------------------
--RQDKQTWKEDQHQHH---------------------Q---QKYGQISKDEQNHQRRDR
QTHIEA-------YNH--------------------------------------------
------------QQ----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------QEDSQTHEKKERYQESQD------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
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---QRRQQGRGHLTKAAHIPPNPFYGYLQEQKSHWY------------------------
------------------------------------------------------------
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-------------

----------------MPQLLRNINEIIEAFGRYANVEGN-CQVLTRGELKRLVEHEFAD
VIV KPHD-----------PA TVDEVLRLLDEDDTGTVDFK-----------E-FLV-L--
-V---------------F-K-V-A-Q-A-C-FKT----LSK----GACG---S-----QE
SGSQ-----ET-R----ASQELGG-QI-NATKA--GTVGKGQ------------------
------------------------------------------------------------
-SEQT-----------SREQGS--------------------------------------
------------------------------------------------------------
--TKT-QTQSQASGHVGQTQSV-EDKNQQIRE------S--------------K-----S
ESQS-----KAKEQDRASQGGETK-TGTA-------------------------------
--------------------------------------------TQTQA--GATKTVEQG
TSHQKGSTSIQTHKSSDGQTKGP----------------E--------------------
-----AHSQDKSQSSQST--QAVTGGQAQAQ-------------TG--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----SYTKTVEQGTSH----------------QKGSTSIQTHKSSDGQTKGPEAHSQDKS
QSSQ------------TTQAVS---GG--KA----------QTQTGSQTQTV--------
-----------------------------------------D------------------
------------------------------------------------------------
----------------------QGRHQSESHTEAGT------------------------
--------------------------------------------------QGGQTQ----
TQSGSGQKWTHVSNYEA-GG----------------------------------------
---------SVQG-------------------------AQAQTGTGTVTGRQEWSSTHSR
YSM----------TGGQG-----------------------EREST--------------
-------RITREWVDDNSSKP---V--RQDQDS----KDT--------------------
------------------NTPSAQAQDTAQ------------PE-KKPGFS-AKG-----
----------L--------------------------YSYFKGSKP--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-------------

----------------MPQLLQNIHGIIEAFGCYARSEGD-CKVLTRGELKRLLEHELAD
VIVNPHD-----------PSTVDEVLRLLDEDNTGTVEFK-----------E-FLV-L--
-V---------------F-K-V-A-R-A-C-FKT----LSESS-RGACM---S-----DM
SECC-----SP-G----SSKELEQ-GQRGGTGG--GRDGAEQCFED--------------
-------SS-------------------------------------------------SG
QRDQV-----------SKKQVR---------------VGTHTQS----------------
------------------------QDSYPTQGSSHDR------------------ELESQ
RQEM-VSQQTQVTGQVAQTPRREDKTW--TRE------R--------------R-----S
EMPS-----QISQQ-----TEEAA-AGPT-------------------------------
--------------------------------------------TQTQG--G--------
--------Q---DRGT-----------------------N--------------------
-----SHSQDRSQADQ------AATQHYQTQ-------------TGSHTQIHTQTVEQGW
RQQTGSDRIQTQ---GSIYE-----------------------------------TQGQD
RNQ---------------AGQAAEE-----------------------------------
-------HQQEK------------------------------------------------
------------------------------------------------------------
------------S-----------------------------------------------
------------------------------------------------------------
---YTHTQTTEQSRSQ----------------QAENSSIQTPGSIYDQNRRTEIHGQDSS
H---------------AEQVGA----G--HF----------QT------QTL--------
-----------------------------------------E------------------
------------------------------------------------------------
----------------------HDRNQSAGRVGAPE------------------------
---------------------------------------------------KGQAQ----
IQSGIVQSCIPESNYET-EE----------------------------------------
---------PGLG-------------------------GQVQSKTN-------WSSNHP-
-SP----------KGGQG-----------------------QRVPT--------------
-------VIRDEWVNDHTREI---VIRSQDPGS----LHS--------------------
------------------RAPSAQGQDAAR------------ME-EKKGIE-AKG-----
----------Q--------------------------YSYLKTDQP--------------
------------------------------------------------------------
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-------------

----------------MPKLLQGVITVIDVFYQYATQHGE-YDTLNKAELKELLENEFHQ
ILKNPND-----------PDTVDIILQSLDQDHNKKVDFT-----------E-YLL-M--
-I---------------F-K-L-V-Q-A-R-NKI----IGK---D-YCQ---A-------
SGSKLRDDTHQ----------HQEEQEETEKE--------E---------NKW-----QE
SSFSHSSWSAG-ENDSYS---RNV-RG---------------------------------
------------------------------------------------------------
----------------------------------------S--LKPGTESIS-RRL----
----------------------------------------------------SF------
---QRD-------------------FSGQH------------------------------
----------------------------------------NSC-SG-------QS---S-
---SYGE----KN--------------------------S--------------D-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------SHQSSG-HS-QC-GSG-SGQ-SPN-YG-QH
-GTG-SG-QS-SSN-GP-HG-SG-SGQSSG-FG---HH---------ES-----------
---GS---------GQ-S---------SGY-SQ-H-----GS------------------
-------------------GSG-HS-----------------------------------
------------------------SS-YGQ-------HGS-RS----------------G
-Q-SS--RGE-R----H-R-SS-SGS-SSSY---GQH-GSG-S-----------------
-------HQ-SSAH-GR-------------------------------------------
-----------------------------Q---GSG-P--GQS-P-S-H-----------
-------------I----RH---GSG-SGHSSSHGQ------------------------
-------HG-SG-SS-CS-SG--------------------------RG-HYE-S-----
-----------------------GSG------------------QT----------SGF-
GQH--ES--GSG-------QSS-GY-SQH-GF----G-SG---------D----SSS-QG
--QHG-SM-SGQ------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------A-S--S-----------S-G-QH-G
-S-S----------S--HQT------------------------SSY--GQHES------
-------ASH------------HASGRGRHGSGSG------------QS--PGHGQ----
---------------------------------------------H-GSGSGQSPSYGQH
-GSGFGR---------SSSSGPYVSGSGYSSGLGHHESSSGHSS--------GYT-----
----------QH------------GSDSGHSSGHGQQGCRSGQS-SRGERHRSSSGSPSS
YGQHGSGSRQ--------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------SSGHGRQG-SGSG--------QSP-SRGRHGSG--SGH
SSSHGQHRSGSSCSSS-----------R-GHYESGSGQASGFGQHESGSGQ--GYSQHGS
GSGHFSSQG--------------RHGSTSGQSSSSGQHGSSSGQSSSYGQHESASH----
------------------HALGRGRHGSGSGQS---------PGHGQHGSGSGQSPSYGR
HGSG--------------------------------------------------------
---------------------------SGQSSS-NGPHGSGSGQSSGFGHHESSSRQS--
--SGYTQHGS--------------------------------------------------
------------------------------------------------------------
----------GSGH--SSSYGQHGSRSGQ-------------------------------
------------------------SSRGERHGYSSGSSSRYGQHGSGSCQSSGHGRQGSG
SGQSPSPSHGRHGS----------------------------------------------
-------------------------------------------GSGQSSSYGPHGSGSGR
S-----S-----------------------------------------------------
-----------------SRGPY--ES----------------------------------
------------------------------------------------------------
------GSGHS------------------------------------------SGLGHRE
SRSGQS-SGYGQHGSSSG--HSSTHGQHGSTSGQS-SSCGQHGASSGQSSSHGQ------
--------------------------H-----------------GSGS--SQSSGYGQQG
SGSGQSPSRG--------------------------------------------------
-----------------------------RHGSSSEHSSSYGQH----------------
------------------------------------------------------------
----------------------------GSGSGCSS-------SNGPHGSGSGQSSGF--
-GHH----------------------------------------------ESGSGQSSGY
SQHG--------------------------------------SGSGHSSG----------
----------------------------YGQHGS-RSGQSS----RGERHRSSSG-----
-------------------SPSSYG--------------QHGSG----------------
----------------SRQSSGHGR-----------------------QGSGSGQSPSRG
R-RGSGSGHSSSHGQHRSGSSC--------------------------------------
----S-----S-------------------------------------------------
SRGHYESG----------------------------------------------------
-----------------------------------SGQASGFGQHES-GSGQSSGYSQN-
----SSGSGHSSSQGQHGSMSGQSSSYGQHGSSSGQSSSYGQHESASCHASGRGR-----
--------H-GSGSGQSP----------------GH------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---GQRG-----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------S--ESGQSPS---YGRH---G--------------SGSGRSS
SS-------------GRHGSGSGQSSG--FGH----------KSSSGQSS----------
-----------------------GYTQHGS--------G-SGHSSSYGQHGSRSGQSSRS
EQHGSSSG-------------------------------------------------SPS
S-----------------------------YGQHGS-GSRQSLG----------------
----------HGQHGSGSGQSP--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------SPSRGRHGSGSGQSSSYGPYGSGS-
-------GWS-----SSCGPYESGSGHSSGLGHRESCSGQSSGYGQHGSSSN--------
-----------------------------H------------------------------
----SSTHGQHGSTSGQSSSCGQH-GASSGQSSSHGQHGSGSSQSSGYGRQ---------
----------------------------------GSGSG---------------------
------------------------------------------------------------
--------QSPGHGQHGSGSRQSPSYGRHGSGS-----------------GRSSSSGQHG
SGLGE-----------------SSGFGHHESSSGQSSGYSQH------------------
--GSGS-------GHS------SGY------GQHGSRSGQSSRGEQHRSSSG--------
LSSSYGQHASGSHQSSGHGQQGSGSGHS----PSRVRHGSGSGHSSSHGQHGSGSSCSSS
RG-HYESGSGQASGFGQHESGS--G--QGYS-----------------------------
----------QHGSGSGHFSSQGRHGSTSGQSSSSGQHGSSSGQSSSYGQHESA------
--------------------SHHALGRGRHGSG-------------SGQSPGHGQHGSGS
GQSPSYGRHGSGSGQSSSNGPHGSGSGQSSGFGHHESSSRQSSGYTQHGS-GSGHSSSYG
QHGSRSGQSSRGERHGSS---------------------SGSSSCYGQHGSGSCQSSGHG
RQGSGSGQSPSPSHGQHGSGSRQSSSYGRHGSGSGRSSSSGQHGSGLG---ESSGFGHHE
SSSEQSSSYSQH------GSGSGHSSSYGQHGSRS--GQSSRGERHGSSSGSS-SSYGQH
GSGSRQSSGHGQHGSGSGQSPSPS-------------------RGRHGSGSGQSSSYGPH
ESGSGRSSGRGPYES---GSGHSSGLGQQESHSGQSSGYGQHGSSS--------------
--------------------GHSSTHGQHGSTSGQSLSCGQHGASSG------QSSSHGQ
HGCGSS--QSSGYGRQGSG----SGQSPGYGQHGSG--SRQSPSYGRHGSGSGRSSSRGP
YKSRSGHSSVFGQHESGSGHSSAYSQHGSG----SGHFCSQ--------------GQHGS
TSGQ--------------------------SSTFDQEGSSTGQSS--------SY-----
G-------------HHGS-------------------GSSQSSGYGQHRAGSGQSLSHGR
HR--SGSGQS--------------------------------------------------
--------------------------------------------------SSY--G-QHG
S-GSGQAS-GYSQHGSGSGQDGYSYC-KGGSNHE----GGSSGSYFLSFPSSTSPYEYVQ
EQRCYFYQ----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------

----------------MPQLLRDILCVIETFHKYAREDGG-AATLTCTELQQLIQSEFED
IFQPCA------------THAVESNLNLLNIDSNGAISFD-----------E-FVL-A--
-I---------------F-S-F-L-N-F-C-YLD----IQS-----LLN---S-E-----
----P-DG-RPHG------MGLQVMN---GT---------DQGTEG---TSQT-------
-----------QDKV----------------VLPS----------------------GTA
SSTHLSLKEE----------------RAVEHNRVD-PQGHTTAHKLPVETSEHSDS----
---KNQHL-------------------------------------------------KGD
-------EQSQKVAQDVSATGDSRTQ-PETSK---PMAGSEQISSRTK-GEG-QNKESLQ
KGD-IL----ARKRSGT------ETGEWF---------------GEQEGSLG--------
--------------------------------------------ILHSPLGETTQRPGG-
--------------SSEDQ----------EEAGEK-GVKE----------HPKAQESSV-
------Q------------------GKDE-P-------------SSDHI---SLP-----
KQAAAWKPSQTQ---KSAAPEDD--SR---------------------------------
-----------------------------------------------TAETPEPPIQE--
------------------------------------------------------------
------------------------------------------------------------
------------------KEYETRDLSVQGDNRNV----PETPTVR--------VERKDV
RGPEVHQTVGQ-KQ--------------------IEE---------------------KI
QPPAL-------------EEPTEDKKY--HELQESS-------KKKNAGEDSET------
-----------------------------------------HELNSEGGEQK-----DSE
I--------------E-------GA----I-SPGEEARHAEEGTEEALVNSKNAPEAEGT
SRTRE----------RTRE-----------------------------------------
--------------------------------------------LTPPEN-QSGEKNKMI
TKIHDK--LVKEDDDYQ-----------------------------------GEGPEPVA
TQNDERSPETPNSLTTEDGDSNSETS---------------D------------------
--------LFVQGDSQ------------------SQANPFRGSV---------QGSDSNN
PET---------------------------------------------------------
------------------------------------------------------------
---------------------------------------------QKHLALSEEKRIQE-
A------VLAVR------------------------------------------------
-GEDERVTEEH----AQEHK-G--------QGSG-----T-TGLGPAVEPRGHPNTQ---
---VFIGRD--ENRKSLEPEIPVAPNAG--FTNQLSVRQLPTKKD---------------
-------------------SRKELKVQSPSTKEEEDGALETQEDLVKSLDENNAVSQ---
--KTHPA-------------TVEEEIESPQQVAGE----QNLSTK-EHDPSVSESGLEER
MQRDQELCLLERGAEHSGPLYEVSQEKMLQQTDVTQG--------------------EHQ
N---------------------------------QAQTASVSSPE---------ICRNQL
SASLTNDSSDCLVFFIDRQALQ---------------KYIREFLPDEDPTGAQQILAPQT
LEDKQSHPQRGELEPQQEESTP----------------------------------K---
-----------------------------Q------------------------------
------------------------------------------------------------
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-------------

----------------MAQLLSSILSVIEVFHKYAKENGD-CALLCKEELKQLLLAEFGD
ILQRPND-----------PETVETILNLLDQDRDGHVDFH-----------E-YLL-L--
-V---------------F-Q-L-V-Q-A-C-YRK----LDN---K-SYG---G-------
RTSQ-QERGQE-G-----AQDRKFPGN-TGT---QH----RQRHEEERQ-----------
-NSHHS-QSERQDRD---------------SH--------------------------SG
QPERQDRDS--HH-GQPERQDRDSHHGQA---------------ERQDRDSHHSQPERQD
RDSHHGQPERQ------------DRD----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------SHHSQPERQ---------------DR
DSHHGQAERQD---RDSHHGQPERQD-R--D------S-----------HHSQPERQDRD
-------------------S--HHG-------------------------------QP--
---ER----QDRDSHHSQPERQD--------------------------------RDSHH
GQPERQDRDSH-------------------------------------------------
--------NGQ-------------------------------PERQDRDSH---------
------HNQSERQD---KDFSFNQSERQSQDSSS-------VQDSHYGQ---S---E-RL
------------------------------------AQQPET-F----------------
------------------------------------------GQDSHFNQTNQQKSGSY-
------------------------------------------------------------
------------------------------------------------------------
-------------------CGQSGRLGQELGCG---------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------QMDRQDQSYHYGQTDRQGQSSHYSQ
MDR-QGQSS------------HYGQTDR--------------------------------
----------------QGQS-----------------SHYGQTDRQGQSSHYGQTDRQGQ
SSHY--SQMDRQGQSYHYGQTDRQGQSSHCGQTDRQSQSYHYGQTDRQGQSS--------
----------CYVQSQT---------G---EI--QGQNKYFQGTEG-TR-----------
--K-ASYVEQSGRSGRLSQQTPGQKGY-QNQGQGFQSRDSQENIHQVWEP----EEDSQ-
-----------HHQHKLLAHI--QQERP--LCHKGRDWQSCSN-----------------
-------------------EQGHRQAKTRQSHGE--------------------------
------------------------------------------------------------
--------------------------G---------------------------------
------------------------------------------------------------
----QSHWA------KEEQGHQ-----------------SWDRHSHEGQEGPCGTQDRQT
PEDEQNHQRRDRQTHEDEQNHQ--------------------------------------
--RQDRQTHEDEQNR-Q-------------------------RRDRQTYEDEQNHQR---
------------------------------------------------------------
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-------------

----------------MSPLLRSIFNITKIFNQYASHDCD-GTTLSKKDLKNLLEREFGE
ILRKPHD-----------PETVDLVLELQDRDRDGLIDFH-----------E-F-L-A-I
-V---------------F-K-V-A-A-A-C-Y--Y-A-L-G-Q-A-SG--L-N------E
K--EA-K-C-E-R-K-A-NP-L--QD-RRR-ED-Q-R-----------------------
-------------------------------RF-------------------------EP
QDRQLEERRL-----KR-----QE-----LE--EL-AEE-EELREKQV-RREQRLQ----
-------------------------------------------------------RREQE
E--Y----------------GGEEEL-QQRPK-------------------GRELEELLN
REQRFE----RQEQR--------------------ER-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------Q---------------------RLQVEQQQ
RQ----------------------------------------------------------
------------------------------------------------------------
---------------------R--------------------------------------
----G---------------------------ELR-----ERQ-EE-VQLQKRETQ--EL
QRE---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---RLEEEQQ----------------------------LQ--------------------
--------------------KQ--------------------------------------
--KRGLE-----ERLLE-----QERREQELRR--KEQ-----------------------
--------------------------------------ERRE-QQLRQ----EQE-----
------------------EA---TQE---------------EI-----SERGESRTSRCQ
WQLESE-------------------------------ADARQRK---VYSR---------
PHR-QEQQ-----SRRQEQELLER------------------------------------
-------------------QQEQ---Q----------I---------REEVQS-------
----------LQEDQGRQRLKQEQRYDQNWRWQLEE-----ESQRRRYTLY---------
-----AK-PAQQEQVR----EEEQ---------------LRLKEEKLQREKRR--QERER
QYREVELQREEERLQREEEQLQ--------REEREKRRR--QEREKQYLEKVELQEEE--
-QLQRQER---EK-----------------------RRQEREKQY----L-----EKVEL
-----QEEEQL--QRQE-REKR-RQERERQYLEK-VEL-Q-EEEQLQRQE----------
-REKR--RQERERQYLEKVEL-QEEEQLQR----------------Q-------------
---------EREKRR-QERERQYLEKV---------------------------------
---------------------------EL------QEEEQLQRQERE---------K-RR
-QERERQYLEKVELQEEEQ-LQRQEREKRRQE----RE-KQYLEKVELQEE-EQLQRQ--
-EREKRRQERERQYLEKVELQEEEQ--LQR--------------E---------ERE-KR
RQERERQYLEKEELQRQEERLQREKEQLQREDRE----KRRQVRERKYLEEE--------
LQQEEDRLQREKQLL---------------------------------------------
----------REDREKRQYLEKVEL---QREEEQL---QRE-------------------
---------------------------------------KRRQERERQYREEELLREEER
LHR-------------------------------KEQQLQ---RE--ECEKRRRQELERQ
L------------------------------EEEELQRLDRKRQFR--------------
-DDDQHQNEVRNSRVYSKHRENKEKSRQLDD-SWVRESQFQQDLRPLQDEQE-----EKR
EREQEWRSRQKRDSQFPAEQL----LEREQ--QK-ETERRDRKFREEEQLLKG-QREEKI
RYLEEDRKFREEEQQLRR-----------------------LEREQQLRQERDRKFREEL
SRQERD-RKFRE-------------------EEQLLQEREEQLRRQERDRKFREEEQLLQ
ERE------------------E-QLRRQERDRKFREEEQQLRLLE-----REQQ------
----------LRQERNRKFREEQLLREREEQ-----------------------------
------------------------------------------------------LRLQEG
EPQLRQKRDRKFHEEEQLLQEREE-QLRRQ------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------ERDRKFREE
EQLLQEREKLRRQEREP-------------------------------------------
------------------------------------------------------QLRQER
DRKFHEEEQLLQEREE--QLRRQERDRKFREEEQLLQERE-K------------------
---------------------LRRQ-----------------------------------
------------------------------------------------------------
----E-REPQLRQERDRKFREE-------------LSRQERDRKFREEEQLLQ-------
-EREEQLRRQERDRKFREEEQLLQER----------------------------------
------------------------------------------E-----------------
-----------------E-QLRRQERD-RKFREEEQLLK-ESE-------EQLRRQER-D
RKFHEKEHLLREREEQ--QLRRQELEGVFSQEEQLRRA----EQEEEQRRQRQRDRKFLE
EGQSLQREREEEKRRVQEQDRKFLEQEEQLHREEQEELRRRQQ-----LDQQYRAEE---
-----------QFAREEKRRRQEQELRQE-EQRRRQERERKFREEEQLRRQQQEEQKRRQ
ERDVQQ----S------RRQ--------VWEEDKGRRQVLE-----AGKRQFASAPV---
-------------------RSSPLYEYIQEQRSQYRP-----------------------
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-------------

----------------MAQLQENINGIITVFYTYARSDGD-SSTLSRGELRQLIEQEFGD
VITDARD-----------PRTVDEVLFFLDEDSSGKIDFG-----------E-FLS-L--
-I---------------F-R-V-A-K-A-C-HRQ----LQQ---Y-LEP-EYDQELTVQE
EADGEQ--QHKQVLEQGVSEQVQEGGTPQQD-----------------------------
---------------------Q------------------------------------DT
QQHQESEEPK----NHQGTQQKQ-EGGTPKY-QDT---QKIEKSEIPKVQDTQKTQEVE-
-TPKNNESTQ------QKK------SETPKDNQDTHQDDRA-------------------
------------K------------T-PEQSP---KRGENVVTKSPEEDRNTQEAEKTPK
H--DPK----PHQDKVTETPKLG-------------------------------------
----------------------------------------QDHH-----QRHELKPAEQS
H---T------------S---------PTKTPGGT-TDKT--------------------
------------------------------------------------------------
----------KD---HVAHWQDPSPKGT----QELPPPVRGTS--PHP-DPRPS-GTQHD
PA------HL-PNP--TVIV--REGSG--------------------AEAE--RV-----
--PGQQQH---GAHGKGKHVAEQ-----EHLQPHWPPRK---------------------
------------------------------------------------------------
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-------------

----------------MAQLLSSILSVIEVFHKYAKQNGD-CALLCKEELKQLLLAEFGD
ILQRPND-----------PETVETILNLLDQDRDGRVDFH-----------E-YLL-L--
-V---------------F-Q-L-V-Q-A-C-YRK----LDN---K-SYG---G-------
RTSQ-QERGQE-G-----AQDRKFPGN-TGT---QH----RQRHEEERQ-----------
-NSHHS-QSERQDRD---------------SH--------------------------HS
QPERQDRDS--HS-GQPERQDRDSHHGQP---------------ERQDRDSHHNQSERQD
KDFSFDQSERQ------------SQDSSSG------SGKK---VSHK--STR--GQTKWQ
G--HI-------F-------------ALNGCE------KP------VQ-----------D
SHYGQ-------------------------------------------------------
---------------SE---------------------------RLAQ-Q----------
------------------------------------------------------------
----------------------P-----ETFGQDSHFNRTNQQKSGSYC---GQSGRLGQ
ELGCGQMDRQD---QSYHYGQTDRQD-Q--S------S-----------HYGQMDRQGQS
-------------------S--RYS-------------------------------QT--
---ER----QGQSSHYSQMDRQG-------------------------------------
------------------------------------------------------------
-----------------------------------------------QSSH---------
------YNQMDRQG---QCYQYGQTDRQGQSSHY-SQPDRQGQSFHYGQ---T---H-R-
---------------------------------------QGQSSHYGQTDR---------
------QGQSSH----YGQTDR--QGQSPH-----YGQTDRQGQSSHYGQTDRQGQSSH-
------------------------------------------------------------
------------------------------------------------------------
-------------------YGQTDRHDQSPHYGQTDR-----------------------
-----------H------------------------------------------------
---------D--------------------------------------------------
---------------------------QSPSSHYGQTDRQGQSSHYGQPDRQSQSSHYGQ
TDR-QGQSS------------HYGQTDR--------------------------------
----------------QGQS-----------------SHYGQTDRQGQSSHYGQTDRQGQ
SSHY--SQMDRQGQSYHYGQTDRQGQSSHYGQTDKQSQSYHYGQTDRQGQSS--------
----------CYVQSQT---------G---EI--QGQNKYFQGTEG-TR-----------
--K-ASYVEQSGRSGRLSQQTPGQKGY-QNQGQGFQSRDSQENSHQVWEP----EEDSQ-
-----------HHQHKLLAHI--QQERP--LCHKGRDWQSCSN-----------------
-------------------EQGHRQAKTRQSHGE--------------------------
------------------------------------------------------------
--------------------------G---------------------------------
------------------------------------------------------------
----QSHWA------EEEQDHQ-----------------SWDRHSHEGQEGPCGTHDRQT
PEDEQNHQRRDRQTHEDEQNHQ--------------------------------------
--RRDRQTHEDEQNY-Q-------------------------KQDRQTHEDEQNRQR---
------------------------------------------------------------
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-------------

----------------MPQLLNSILNVSKVFQDYAEYHGV-GASLSKKELKQLLLTEFGD
ILRRPND-----------PETVETILEHLDRDRNGYVDFH-----------E-YLL-L--
-V---------------F-Q-L-V-Q-A-C-HHK----LDG---K-FHG---S-------
RTSSEREHDQE-G-----TRSHKFSKS-AGR---QH----RQRYEGERR-----------
-NSHHN-QSEGQHQNVQH--DQ-AQRQDKDS-----------------------------
-----------------------------ERHDTD---PHCGQSETFHGDSHYGHSERQD
TDYSSDQSE------------SDNESSSSNQRLGY-------------KSSH--EQPKGQ
G--YV-------F-------------ALSQSK------KP------EQ-----------T
FHYGQS-----------------KTSGQQS------------SHGQ-SGRFR--------
--------KDSYSSQTS----------Q-----QESDSYEQY-GSQHQ-KSGNSQTERQG
QNSQYGQTNKKGHSSYHEQTE---------------------------------------
-----------------GQGQSFHYGQKGRQGQ------------SFQQ---GQKGRQDQ
SPHXXXXXXXX---XXXXXXXXXXXX-X--X------X-----------XXXXXXXXXXX
-------------------X--XXXX------------------------------XX--
---XX----XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXX-XXXXXXXXXXXXXX-----------XXXXXXXXXX------------XXXXXXX
XXXXXXXXXXXX-----------XXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-------XXXXXXXXX---X---XXXX
XXXXXXXXXXXXXXXXXXXXXX-------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXX--------------------------------------------------------
------------------------------------------------------------
-------------------XXXXXXXXXXXXXXXXXXXXX--------------------
---------XXXXXXXXXXXX-XXXXXXXXX-------XXXX-XXXXX-XXXXXXXXXXX
XXXXXXXXXXXXXXXXX-XX-----------------------------XXXXXXXXXXX
XXX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGQ
KGR-QDQSPHRGQK----------------------------------------------
--------------GRQDQSSHQGQKGRQDQSSH---------QGQDQNSHWHRTDRQGQ
SFHF--DQAGREVQGSH------------------------QGQ----------------
--------------TDRQSQSSHCGQSEIGKTENQGQNRHSLGTDR-TR-----------
--R-DSYVEQSGRSGKLSQQNSREEVS-QTQSQRSHDRREQQIQQQTWKP----KEDN--
-------------QHKLLAQV--HQ-EP--YSHEEYDWQSQSS-----------------
-------------------EQDH-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------CG-------EE-EYQ-----------------DWDRDSIEDQENLYEMQNWQT
HEEEQSHQTSDRQTHVDKQNQQ--------------------------------------
--RQHRQTHEENHDH---------------------------QHGRHH-EDEHNHRR---
-K----------------------------------------------------------
------------------------------------------------------------
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---------------------------------D--------------------------
---HHQQRERQTHEENEKYQGGQDQ-----------------------------------
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------------------------------------------------------------
------------------------------------------------------------
-------------------------------SRSFPNREKSHMSED--------------
----------------------DQCEGP---------QGRHFH------------PTHGG
GKSQRREKSGNHPTKPA-NYSSPLYDYVQEQAAYQY------------------------
------------------------------------------------------------
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-------------

----------------MTDLLRSVVTVIDVFYKYTQQDGE-CGTLSKDELKELLEKEFRP
ILKNPDD-----------PDTVDVIMHMLDRDHDRRLDFT-----------E-FLL-M--
-V---------------F-K-L-A-M-A-C-NKV----LSK---E-YCK---A-------
SGSKKHRHSRQ----------YQDEESETEEE--------EE-------DTSG-----QK
SGYKYSSWSEG-EEHGYS---SEGLRGSAKQRHGS-------------------------
--RRLGRHG------------------------DLSSSENQKGSE-KRHCGSSS------
---------------------------GHSQS--------S--GKQRHGSSS-GELGERR
S--------------------------KSRV-------------NPSR----ES-----G
EEYESG-------------------SGS--------------------------------
-------------------------------------------GSRSGGRKSHGGLSHGL
DIS--EH-----E-S---------------------------------------------
-S---------------------------------------------------------K
SSGCGRP---QN---ASSSYQEGQFGGQGNQSSCT-PSGYESGSSGGQGHRCLSGGQSCG
YGQ-----HEPSSCG-QSSSQRGYGS----------------------KACGQ--PQNC-
GAQQGTG--SSQSSCCGQN-----------------------------------------
-----------------------------------------------E-------S----
-GASQSSNYGQH-----------G-SSC-GYSSKSHQKGSGSNEYS--------------
---KC--------G--QHRSSSGQS------T-GFGQ-----------------------
---------------------------------------HGSGSG---------------
---QFSG---------FEQGSC---S----------------GQSPSFGKQ---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------GSGSGQS-
------------SGSGQ-HGPSSHQ-----------------------------------
-----SSSFEYHESRSGQ-SGSGQHG-----------SGSGQSSGFGHHGS---------
A-----------------------------------------------------------
-------------SGQSSGSGQH---G----------S------GPHQSSSFE-------
----------HH-ES-------RSG-----------------------------------
-----------------------QS-G-----C---------GQHGSGS-----------
------------------------------------------------------------
-GQSSGSGQ--HG---------------------SG------------------------
----------------------------------S-------------------------
---------------------------GQSGCGQH-----GS------------------
------------------GSGQSTG-----------------------------------
------------------------SGKHGSA------SGQSSG-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------SGQH-----------------------
-------GSSSHQSSSFEHHES-RS-G-QSG--------------------SGQHG-SGS
GQSSG-FGQHA-------------------------------------------------
----------S------GSGQSSGWGQHGSGS----GQY----------S---------G
SGQHG-SGS-GQ--SSGSG-KHG-SSSHQS---SSFEYHESRS--GQS------------
--------------------------------G-C-------------------------
------------------------------------------------------------
-------G--------------------------QH-GSG--------SG-QSSGF----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------GPHG--------SGSG-QSSGF--GRHGS------
-------ASG------------QSSGSGQHGSASGQSSGSGQHGS-SSH-QSS-SF---E
HH-ES-RS-GQ-SGS-G-QHGS-GS-GQ-SS----------GSG-QHGSSSSGQSGCGQH
-GSGSGQ---------SSGCGQHGSASGQSSGSGQHGSGSGQSSG--------SG-----
----------QHGSSSHQSSSFEHHESRSGQSGCGQHGSGSGQS-SGFGLHGSASGQSSG
SGQHGSGSGQSSGSGQHGSSS------------------------HQSSSFEHH------
ESRSGQ------------------SGCGQ---HGSGS------------------G----
----------QSSGCGQHGSA---------SGQSSG------------------------
------------------------------------------------------------
-----SGQ------HGS----GSGQ----S------------------------------
----------------------------SGSG----------------QHGS-------S
S------HQS--------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------SRQ--S
G-CGQ-H-----------GS-GSGQSSGFGLHGS-ASGQSSGSGQHGS-GSGQ-SS----
---GSGKHGSG--------QSGC-GQ-------------HRS---GS---GQSSGSG-KH
GSGSG---QSSGSGQHGSSSHQSSSFEHHE-SRSG--------QS--GSGQHGSG--SGQ
SSGFGQHASASGQSSG------------SGQHGSALGQSSGSGLHGSSSGQSSGCGQHGS
GSGQSSGSG-----KH----GFEYHESRSGQ-SGYGQLGSGSGQSSGFGQHRSGSGQ---
-------------------SSGFGPHGSASGQS---------SGSGKHGSASGQSSGSGL
HGSSS------------------------------------------------------H
QSSRQSGSGQHGSGSGQSSGFGQHGSGSGQSSGASQ------------RHSASTHGQA--
--GSQ-------------HG------------------DSASTVRGRRG-SAHGQSQHGD
SGS-TVR----GSPGSAHGQAGSQHGESGST-----------------------------
------------------VRGGQGPARGQS-----------------------GDTSRHG
QSSHGQSTHSESRTAGRRGSSQSESSDGEGHSGASQR---------HSAS--THGQAGSQ
HGDSGSTV----------------------------------------------------
-----------------------RGRQETDHRQVGSQ-----------------------
------------------------------------------------------------
----HREHGQSSHGQSTHSESR--TAGRRGSSQSES-SDGERHSGASQRHS--ASTHGQA
GSQHGESGS--TVRGGQGPARGQSGDTSRH----GQS---SHGQSTHSESRTAGRRG-SS
QSESSDGERHS-----------------------------------------GASQRHSA
STHGQAGSQHGDSESTVRGSPGSAHGQSGDTSRHG---------------------QSSH
GQSTHSESRTAGRRGSSQSESSDGERHSGASQRHS--ASTHGQAGSQHGDSGSTVRGRQE
TDHRQA-------------------------------------------------GSQ--
HGEHGQ------------SSHGQSTHSESRTAGRRGS-----------------------
------------------------------------------------------------
-SQSESSDGERHSGASQRHSA-----Y-THGQAGSQHGDSGSTVRGSPGSAHGQSGDTSR
HGQS----SHGQS-------------------------THS-ESRTAGKRGS-SQSESSD
GERH-----------------------------SGASQRHSASTHGQAGSQH------GE
SGS------TVRGGQGP-ARGQSGDTSRHGQSSHGQSTHS--ESR-TAGRRGSSQSESSD
GERHSGASQRH-------------------------------------------------
--------------------------SASTHGQAGSQHGDSGSTVRGSPGSAHGQSGDTS
RHGQSSHGQSTHSESRT-----------------------------------------AG
RRGSS-------------------------------------------------------
------------------------------------------------------------
----------------------------------QSESSDGEGH--SGASQRHSAS----
-------------------------------T-HGQAGSQHGDS----GSTVRGRQETDH
RQSGDTSRHGQSSHGQSTHSE------SRTAGRRGSS-----QSESSDGERHS-------
-----------GASQRHSAS----------------------------------------
--THGQAGSQHGDSG---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------STVRGGQGPARGQSGDTSRHSQSSHGQSTH----------SESRTAGRRGS
SQSESSDGEGHSGASQRHS-----------------------------------------
----AS---------------------------THGQAGSQHGDSGSTVRGRQETDHRQS
GDTSRHGQSSH---------------GQSTHSESRTAGRRGSSQSESSDGERHSGASQRH
S-----------------------------------------------------------
-------------------------------------------------AYTHGQAGSQH
GDSGSTVRGGQVPARGQSGDTSRHGQSSHGQSTHSE-----SRTAG--------------
------------------------------------------------------------
--------------RRGSSQSESSDSERHSG-ASQRHSASTHGQAGS-------------
----------------------QHGDSGSTVRGRQETDHRQSGDTSRHGQSSHGQSTHSE
---S-------RTAGRRGSSQS------------E-------------------------
-----------------------------------------SSDSERHSGA---------
-----------------SQR--HSAFTHVQAGSQYGAPGHSGSGTIERHW-SSHSQSHDF
HTQS-----QDNLSTPSSS--HHAHSVISHSQSQIGKRQRNVSGQGWS---HGSYGREE-
-------------------------------YDYGQSGYGPSGGSRTS-SR-NSSPLRSS
AIVGIKQES-----KHGHSVSTSEHVGSKNRERAA-TEHSSSWSEISHG-QSSDSHNESE
SSITTRHRS-IHGHSVATQEQSRDTHVQ-------SGRHI---S-----------THSSQ
P---------------------------SNCSVSGLGQYLSAPSHSDSSS-MRKQGSHSD
SKEHSEDWGENIHE---QLGSRHGQSEFNSVGIYGSSQKHLGDTSHVQVRYST---NLAR
QGSSDRQSG---------------------------------------------------
DIESYSE--FSTNERLLYSNSQSSDNYGPSIV----------------------------
-----------------SRLIDSEDPTGTEEFRHRYSSGSTTTWFGERQK---Q----ES
ASSLLGSMKLYSQG--G-------------KQTRVSEARGYHGRERTDSSSFHSDSITPL
--YEYVQ--------------------EQKCYY-----------LE--------------
------------------------------------------------------------
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-------------

----------------MSALLESITCMIEIFQQYSTSDKE-EETLSKEELKELLEGQLQA
VLKNPDD-----------QDIAEVFMQMLDVDHDDKLDFA-----------E-YLL-L--
-V---------------L-K-L-A-K-A-Y-YDA----SKK---E-RFQ---T-------
HESNRRSKNYY----------KGLEEEEEEGEE-QS--L-RRRHGGTDGK----------
-------------------------R---K---SD-----------------------RT
PSPG-GRGGKRQE-S--------------KCRNEGRDKQKR---E-TEKHRHQQ------
---------------------------DSNRKHRH-GSGST--ERKDNRN----RRHRQS
K--------------------------ERNY--------------AEIYDNGNY-----N
EDWEAS-------------------YNNCY------------------------------
------------------------------------------------YKTENATLDERE
KNR-R------SRPDYQK---------EPQSSHGQADNSD--------YEGGRQQSHSRS
SP--LSAGQSRSSAGEAN--SPRVSARSGSGXRG------------------------QS
PDGSGRS---SS---RRD------------------RPRQ------------PSPSQSSD
------------SQV-HSXAQ-VEARR--------------------GQSSS--------
-A----------------------------------------------------------
------------------------------------------------------------
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-------------

----------------MPRLLRDVLCVIETFHKYASEDSN-GATLTGRELKQLLQGEFGD
FFQPCV------------LHAVEKNSNLLNIDNNGIISFD-----------E-FVL-A--
-I---------------F-N-L-L-N-L-C-YLD----IQL-----LLS---S-ELRQ--
-VTKP-EKEKPDD------VDLQATT---GD---------GQWTAG---TSPT-------
-----------QEER----------------MLPS----------------------GMA
SLSQLIPEES----------------GAVGNNRVD-PWREAKTHNFPGEASEYNDP----
---KNQHL-------------------------------------------------EGD
-------EQIQEVAQDVQTTEDNEGQ-LKANK---PMARSKQTSSPTK-RKG-QDKKISQ
EGD-EP----VREQSVS------KIRDHF---------------GEQEGNLE--------
--------------------------------------------PQNSPPEEETQRPSE-
-----------------DQ----------EVRTEK-E--K----------YSNTQEPPL-
------Q------------------GEDE-P-------------SSERA---DLP-----
EQAAARTLSQTQ---KSTDPEDV--CRT----FDTQDPGKDAD------------QTPAE
------------TTN--SGEPEDYGR---------------------TSETQE-------
------------------------------------------------------------
------------------------------------------------------------
------------------KESETKDLPVQGGSRNG----SETPDMR--------DERKER
RGPETHETAGQ-KE--------------------RDR---------------------KT
QPLVL-------------ETQTQDGQY--QEFQGLS-------KSKDAKKDSET------
-----------------------------------------QYLSSEGGDQT-----HPE
L--------------E-------GT----A-VSGGEAEHTKEGTTEAFVNRKNAPAAART
LGARE----------STQD-----------------------------------------
--------------------------------------------LAPLEK-QSAGENSRA
TKTHDK--PVEEEDGYQ-----------------------------------GEDSESPF
TQNDEGSSETPSSLASGEDNSSSETG---------------E------------------
--------LSMQGDSK------------------SQGDPHGGSV---------QGGHNNN
PDT---------------------------------------------------------
------------------------------------------------------------
---------------------------------------------QRQGTPGEKNRAQEA
V------VPAVR------------------------------------------------
-GEDVQLTDDQEQPSRGEHK-Y--------QGPG-----T-KGPGAAVEPSGHPEAQ---
---ESTAGD--KNRKSLEIEITGALDED--FTDQLSLMQLPGKED---------------
-------------------SRNELKVQGPSSKEEKGRATEAQNTMLKSLDKDNSASH---
--KIQLETKE-------TVTS-EEEDESPQELAGEGGDQKSPAKK-EDNSSVPWPSLEKQ
VQRDQEPCSVERGAIHSSPLYQYLQEKILQQTNITQE--------------------DHQ
K---------------------------------QVQIAQASGPE---------LCS---
-VSLTSETSDFSVFFNYSQASQ---------------PYTRGLPFDESPAGA---PSPQA
LEDKQDYPQRERLVPQREASTT----------------------------------K---
-----------------------------Q------------------------------
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-------------

----------------MSKLLRGVFCIIETFHKYASKDGDDKARLTHRELRQLLEGEIGN
FLQPQV------------FHAVERKLNLLDVDRDGAISFE-----------E-FLL-E--
-I---------------F-S-L-L-N-L-F-SFD----I-S-----LLN---S-EPRL--
-MSKS-EK--MDG------VDLLETT---RS---------SQKVVG---VGPT-------
-----------QERL----------------VLAS----------------------ETV
SSAKPSREED----------------ETDGHNRMS-PLEDIKTHNLPREVSEPNDP----
---ENQHP-------------------------------------------------EED
---------SQEVAQDVPATESDEVQ-FKRNM---SMEASKQSNSPTQ--------VIPK
ERG-KV----VRRQSDT------KVSDHM-------------------------------
-----------------------------------------------------AQRPSE-
-----------------DE------------------EHA-----------STTQDPLP-
------R------------------KEDR-A-------------TSEHV---DLP-----
VEAAAGKPSGTQ---KVVELMDD--TRI----SETGEPGKDAG------------RTPPE
------------TTN--LENPKADSR---------------------TSETQGLPERV--
------------------------------------------------------------
------------------------------------------------------------
------------------RKQETRNQTAQSGSRDD----LETSSRG--------K-----
------WEEGQ-KE--------------------HER---------------------KT
GSQAP-------------EAQTLDEKC--QEFSRSW-------RENGARKGSGT------
-----------------------------------------QGLSSEKGNEN-----LPE
I--------------K-------EE----Y-ISGKEGRHCEKDIEDAFLSSKESPAAEET
QETRE----------SSQE-----------------------------------------
--------------------------------------------PAPLEK-QSQGKSHRA
TRTRDQ--PARKEAHSE-----------------------------------GEDPEVPV
TQSDEDLCETPSGPAPEVGNSSSDSS---------------E-------------P----
--------RGLPGDLQ------------------SQTDTQGDAK---------QGSDSNN
PDP---------------------------------------------------------
------------------------------------------------------------
---------------------------------------------QKQGVPGESSGVKEA
V------ELSIQ------------------------------------------------
--EGSQLPEEQEQSAREK----------------------QDGLGAAVEPTEEGEVQ---
---ESTAGG--ENRKSPEAESSGAQ-----------------------------------
------------------------------------------------------------
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-------------

----------------MTDLLRSVVTVIDVFYKYTKQDEE-CGTLSKDELKELLEKEFRP
ILKNPDD-----------PDTVDVIMHMLDRDHDRRLDFT-----------E-FLL-M--
-V---------------F-K-L-A-L-A-C-NKV----LSK---E-YCK---A-------
SGSKKRRHGHQ----------HQKEESETEED--------EE-------DTPG-----RK
SGYRHSSWSEG-EERGYS---SGGSRGTMKRRHGS-----------------------N-
-SRRLGRQG------------------------NLSSSGNQERSE-KRHHRSSS------
---------------------------GHSWS--------S--GKERHGSSS-GELGGRI
N--------------------------KSHV-------------SPSR----ES-----G
EEYESG-------------------CG---------------------------------
--------------------------------------------SKSWGRKGHGGLSRGL
ETS--QH-----E-SNST---------QSRSR-GQKL-----ESNCSGSGGSGRQSHAHG
YS---------------------------------------------------------N
SSGCGKP---QT---ASSSCQSHRLGGQGYQSSCT-QSGCQSEINGGQGHGCVSGGQPSG
CGQ-----SESNSCG-QSYSQRGYGA----------------------REHCQ--PQNC-
AGQQRTG--TGQSS-CGQY-----------------------------------------
-----------------------------------------------R-------S----
-GGSQSCSNGQH-----------EYGSC-GHFSNSSS----SNEFS--------------
---KR--------G--QHWSGSGQS------T-SCEQ-----------------------
---------------------------------------HGTGL----S-----------
---QSSG---------FEQHVS---G-----------------SGHTCRQH---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------GSRSSQS-
------------SGYDQ-HGYSSGQ-----------------------------------
-----TSGFGQHGSGSGLSSGFGQCG-----------SGSGQSSGFGQH-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------GSGSGQSSGFGQHES-RS-G-QSS--------------------YGQHG-SGS
SQSSG-YGQHG-------------------------------------------------
------------------SRQTTGFGQHGSGS----GQS----------A---------G
FGQYG-SGS-GQ--SSSFG-QHE-SRSG------------------NS------------
--------------------------------N-Y-------------------------
------------------------------------------------------------
-------G--------------------------QR-GFG--------SN-QSSGY----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------GQHG--------SSSG-QTSGF--GQHES------
-------GSG------------QYSGFGQHGSGSGQSSAFGQHGS-GSG-QSS-GF---G
QH-ES-RS-SQ-SRY-G-QHGT-GS-SQ-SS----------GYG-QHGS-----------
---GSGQ---------SAGFGQHGLGSGQSSGFRQHGSGSGQSSS--------VG-----
----------QHEFRSGHSSYGQRGTGSSQSSGYGQH-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------GSS-SG--Q--TSGF-GQ-------------HES---GS---GQYSGFG-QH
GSGSG--HQSSGYGQHGSSSGQTSGFGQYG-SGSG--------QS--SYGQHGTG--SSQ
SSGYGQHGSSSGQTSG------------FGQHRTGSGQSSGFGQYGSGSGQSSGFGKHGS
GTGQTSCFG--------------QHEYKSGQ-SSYGEQGTGSSQSSGYGKYRSGSDA---
-------------------ITGFGQHESDSGHF---------SNSGQHISGSGQSTG---
------------------------------------------------------------
-------FGQYGSGSGQSTGLGQSVSQKGESGPRVH------------SRQETTHGQT--
--VDTTRH------GQYGHG---------------QSTQIGSRTTRRRR-SSQSENNESD
DHSRVSQ----RHSEHAHTQVGSQQPESGST-----------------------------
------------------VQGRHRTTHGQT-----------------------GDVTGHA
HSGHGQSTQRGSRTTGRQRSSHSDD--SEVHSGFSHT---------HS--G---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------HTQGQA
GSQQGESGS--TVQGRHRATHGQTGDVTGH----AHS---GHGQSTQRGSRTTGSRG-SG
HHEASDSEVHS-----------------------------------------GVSHTHSG
HTQGEVGSQQGESGSTVQGRHRTTHGQTGDVTGHA---------------------HSGH
GQSTQRGSRTTGSRGSGHSESSDSEVHSGFSHTH--SGHTQGQAGSQQGESGSTVQGRHR
ATHGQT-------------------------------------------------GDVTG
HAHSG---------------HGQSTQTGSRTTGRQRS-----------------------
------------------------------------------------------------
-SHSESSDSEVHSGFSHTHSG-----H-TQGQAGSQQGESGSTVQGRHRATHGQTGD---
------------------------------------------------------------
------------------------------------------------------------
-------------------------VTGHAHSGHGQSTQR--GSRTTG-SRGSGHHEASD
SEVHSGVSHTH-------------------------------------------------
--------------------------SGHTQGEVGSQQGESGSTVQGRHRTTHGQTGDVT
GHAHSGHGQSTQRGSRT-----------------------------------------TG
SRGSGHSESSDSEVHSGFSHTHSG---HT----------------QGQAG---------S
QQGESGSTVQGRHRATHGQTGDVTGHAHSGHGQQ--------------------------
-------------------------------RSSHSESSDSEVH--SGFSHTHSGH----
-------------------------------TQG-EVGSQHGES----GSTVQGRHRTTH
GQTGDVTGHAH-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------SGH---------------GQSTQRGSRTTGTRGSGHQEASDSEVHSGFSHRP
HSQ---------------------------------------------------------
-------------------------------------------------EHTQGEVGSQH
GESGSTVQGRHRTTHGQTGDVTGHAHSGYGQSTQRG-----SRTTG--------------
------------------------------------------------------------
--------------SRGSGHHESSDSEVHSG-FSHTHSGHTQGEVRS-------------
----------------------QHGESGSTVQGRHRTTHGQTGDVTGHAHSGHGQSTQRG
---S-------RTTGSRGSGHH------------E-------------------------
-----------------------------------------ASDSEVHSGF---------
-----------------SHRPHSQEHTQGEVGSQHGESG----STVQGRHRTTYGQTGDS
IRRSFSGHGQSTQTGSRSS--R---TSHFQSH--GSERQRHGSSQAWK---HGSYGSAD-
-------------------------------YDYGHTGYGPSGD-SRQ-SSQNSHTAWFI
DSTANK--SLSRH-----------------------------------------------
------------------------------------------------------------
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-------------

----------------MPQLLRNVLCVIETFHKYASEDSN-GATLTGRELKQLIQGEFGD
FFQPCV------------LHAVEKNSNLLNIDSNGIISFD-----------E-FVL-A--
-I---------------F-N-L-L-N-L-C-YLD----IKS-----LLS---S-ELRQ--
-VTKP-EKEKLDD------VDVQATT---GD---------GQWTVG---TSPT-------
-----------QEER----------------MLPS----------------------GMA
SSSQLIPEES----------------GAVGNNRVD-PWREAKTHNFPGEASEHNDP----
---KNKHL-------------------------------------------------EGD
-------EQSQEVAQDIQTTEDNEGQ-LKTNK---PMAGSKKTSSPTE-RKG-QDKEISQ
EGG-EP----AREQSVS------KIRDQF---------------GEQEGNLA--------
--------------------------------------------TQSSPPKEATQRPSE-
-----------------DQ----------EVRTEK-E--K----------HSNIQEPPL-
------Q------------------REDE-P-------------SSQHA---DLP-----
EQAAARTPSQTQ---KSTDSKDV--CRM----FDTQEPGKDAD------------QTPAK
------------TKN--LGEPEDYGR---------------------TSETQE-------
------------------------------------------------------------
------------------------------------------------------------
------------------KECETKDLPVQYGSRNG----SETSDMR--------DERKER
RGPEAHGTAGQ-KE--------------------RDR---------------------KT
QPLVL-------------ETQTQDGKY--QELQGLS-------KSKDAEKGSET------
-----------------------------------------QYLSSEGGDQT-----HPE
L--------------E-------GT----A-VSGEEAEHTKEGTAEALVNSKNAPAAERT
LGARE----------RTQD-----------------------------------------
--------------------------------------------LAPLKK-QSVGENTRV
TKTHDK--PVEGEDGYQ-----------------------------------GEDPESPF
TQSDEGSSETPNSLASEEGNSSSETG---------------E------------------
--------LPVQGDSQ------------------SQGDQHGESV---------QGGHNNN
PDT---------------------------------------------------------
------------------------------------------------------------
---------------------------------------------QRQGTPGEKNRALEA
V------VPAVR------------------------------------------------
-GEDVQLTEDQEQPARGEHK-N--------QGPG-----T-KGPGAAVEPNGHPEAQ---
---ESTAGD--ENRKSLEIEITGALDED--FTDQLSLMQLPGKGD---------------
-------------------SRNELKVQGPSSKEEKGRATEAQNTLLESLDEDNSASL---
--KIQLETKE-------PVTS-EEEDESPQELAGEGGDQKTPAKK-DHNSSVPWPSLEKQ
MQRDQEPCSVERGAVHSSPLYQYLQEKILQQTNVTQE--------------------EHQ
K---------------------------------QVQIAQASGPE---------LCS---
-VSLTSEISDCSVFFNYSQASQ---------------PYTRGLPLDESPAGAQETPASQA
LEDKQGHPQRERLVPQREASTT----------------------------------K---
-----------------------------Q------------------------------
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-------------

----------------MAQLLNSILSVIDVFHKYAKGNGD-CALLCKEELKQLLLAEFGD
ILQVRYT-----------DT----------------------------------------
---------------------------------------QD---Q-MTQ---R-------
LTSQ-QERGQE-G-----AQDRKFPGN-TGR---QH----RQRHEEERQ-----------
-NSHHS-QPERQDGD---------------SH--------------------------HG
QPERQDRDS--HH-GQSEKQDRDSHHSQP---------------ERQDRDSHHNQSERQD
EDFSFDQSERQ------------SQDSS--------SGKK---VSHK--STS--GQAKWQ
G--HI-------F-------------ALNRCE------KP------IQ-----------D
SHYGQ-------------------------------------------------------
---------------SE---------------------------RLTQ-Q----------
------------------------------------------------------------
----------------------S-----ETLGQASHFNQTNQQKSGSYC---GQSERLCQ
ELGCGQTDRQG---QSSHYGQTDRQD-Q--S------Y-----------HYGQTDRQGQS
-------------------S--HYS-------------------------------QM--
---DR----QGQSSHYSQPDRQG-------------------------------------
------------------------------------------------------------
-----------------------------------------------QSSH---------
------YGQMDRKG---QCYHYDQTNRQGQGSHY-SQPNRQGQSSHYGQ---P---D-T-
---------------------------------------QGQSSHYGQTDR---------
------QDQSSH----YGQTER--QGQSSH-----YSQMDRQGQGSHCGQTDRQGQSSH-
------------------------------------------------------------
------------------------------------------------------------
-------------------YGQPDRQGQSSHYGQTDR-----------------------
-----------Q------------------------------------------------
---------G--------------------------------------------------
-----------------------------QSSHYGQTDRQGQSSHYSQPDRQGQSSHYGK
IDR-QDQSY------------HYGQPDG--------------------------------
----------------QGQS-----------------SHYSQTDRQGQSSHYGQTDRQGQ
SSHY--SQPDRQGQSSHYGQMDRQGQSSHYGQTDRQGQSYHYGQTDRQGQSS--------
----------HYIQSQT---------G---EI--QGQNKYFQGTEG-TR-----------
--K-ASYVEQSGRSGRLSQQTPGQEGY-QNQGQGFQSRDSQQNGHQVWEP----EED---
-------------------------KRP--LCHKGRDWQSFSS-----------------
-------------------EQGHRQAQTRQSHGE--------------------------
------------------------------------------------------------
--------------------------G---------------------------------
------------------------------------------------------------
----LSHWA------EEEQGHQ-----------------TWDRHSHESQEGPCGTQDRRT
HEDEQNHQRRDRQTHEHEQSHQ--------------------------------------
--RRDRQTHEDKQNR-Q-------------------------RQDRQTHEDEQNHQR---
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-------------

----------------MSPLLRSICDIIEIFNQYVSHDCD-GAALTKKDLKNLLEREFGA
VLRRPHD-----------PKTVDLILELLDRDCNGHVDFN-----------E-F-L-L-F
-I---------------F-K-V-A-Q-A-C-Y--Y-A-L-D-Q-A-TG--L-D------E
D-KRT-L-C-D-G-K-E-NL-L--QD-RRQ-ED-Q-R-----------------------
-------------------------------RF-------------------------EP
QGRQPEGERG-----QRPRQKTQE----QER--ER-TEG-EEQREKQE-RLEQRDR----
-------------Q-R--------------------------------------------
-----------------------------------------------------RDEELPD
DE-QQR----RRELQ---------------------E---LRRESREEKQQQRQ------
-------------E------------------L--QERVLQEEEGKLQ-KR--------E
-----------------------------RQEQRE-RLED-------------E--PQR-
-----QRELQE-EEEQL--------QKRERQ---------------------ELKRERQE
EE----Q--QLQ---RLRREQEERREQE-E-----------------------------E
KR--------------EQQL-----RRKQEDRREQQLR----------------------
------------------------------------------------------------
-----------------------------------------------REEEERREQ--RL
KREQEERREQQL------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----RREE----------------------------------------------------
-----------------------------------------EERREQRLKREQEE-----
--------------------------------------------------------RRER
QLRREE---------------EEERREQEERR--EQQLRR-EVE------DE--------
----------RREQRLRR-----------------------E-QEERR----EQELA---
---------------E--EE---EQE---------------QV-----RERIKSRTPKWQ
WQLERE-------------------------------ADARQSK---VYSR---------
PRR-QEEQ-----RRRQEQEEKRR------------------------------------
-------------------RRER---E----------L---------QQ---Q-------
----------EEEPARRQQQQEEQRRDFKWQWQAEE-----ESERRRQRLS---------
-----V-RPSLREQRQRQLRAEER----------LPREQRFLQEEEEQE------QRRE-
REQELKFLEEEEQLQRGERTQQLQEEEDGLHEDQEKRRRQEQRRDQKWRWQ--LEEER--
-N---------RRRHTLYA-------KP------ALREQLRKEEQ----L-----QQEE-
--------EQLL--REE-PEKRRRQELERQYREE-EEL-QQEEEQLLREE----------
-REKRR-RQERERQYRDEEEL-QQEEEQLLR--------------EE-------------
---------REKRRR-QERERQYRKEEELQQ-------------------------EEEQ
LLR---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------EE------------------
------------------------------------QEKRRRQERERQYRDEEELQ----
--Q-------------------------------EEXXXX---XX--XXXXXX-------
----------------------------------------------------XXXX----
XX------------XXX-----------------------------XXXXXX--------
------------------XXX----XXXX--X------------------XXX-X-----
----XXXXXXXX------------------------------------------------
XX---------XXXXXXXXXXX---------XXXX-------------------------
------------------------------------------------------------
----------------------------------------------------------XX
XXXX--XX----XXXXX-XX----------------------------X-----------
----------------------XXXXXX--------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------XXXXX---
-------------------------------X------------------XXX-------
--------------X------X------X-------------------------------
---X-----XX-------XXX------------XXX------------------------
------------------------------------------------------------
------------------------------------------------------------
-------XXXXXXXXXXXXX----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------XXXXXXXXX-XXXXEEQLRKEREE-------QQVSRQER-D
RKFREEE--------Q--QLRRQERDRKYRREEEQLQL----EEQE--------------
------------------------------------EQRRRQE-----RDRQYRAEE---
-----------QFARQEKSRHQEQELRQEEEQRRRQERERKFREEQ-LRRQQEEEQRPR-
-----Q----V------REI--------QSQEGKGYGRLLE-----PGARQFANVPV---
-------------------RSSPLYEYIQEQRSQYRP-----------------------
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----------------MAQLLNSILTVIEVFQKHAKENGN-CTSLCKKELKQLLLVEFGD
ILRRPND-----------PETVETILSLLDKDRNGHVDFH-----------E-YLL-L--
-V---------------F-Q-L-A-Q-A-C-YHK----LNN---R-SCG---D-------
RISQ-QEGEQE-G-----TQDHKFPEN-TGR---QH----RQRHEEERQ-----------
-DSHCT-QSERQNQD---------------VH--------------------------QD
QSERQGRDS--CY-GQAERQDMDSHCGQS---------------ERQDRDSHYGQSERHV
RDPHYGQSERQ------------DTDSHYGQRWSH-------------KSSS--SQPKKQ
G--YI-------F-------------ALNQCE------RQ------IH-----------N
SCYGQ-------------------------------------------------------
---------------TN----------Q-----QESGFYYGPSGRLDQ-KSGYGQRDRQE
LDSQYSQTDRQDQSSHSSQ--TV-------------------------------------
-----------------RQGQNSHYGHTDRQGQNSCYGQIDRQSQSSRY---GQTDRQGQ
NSRYGQTDRQG---QSSHYGQTDRAG-Q--S------S-----------HYDQSDRQGQS
-------------------S--HYG-------------------------------QT--
---DR----QGQNSPYDQTDRQG--------------------------------QNSRH
GQTDRQGQNCCYGQIDRQGQ----------------------------------------
-----NSRHGQ-------------------------------TDRQGQSSRY-G--QTDR
QGQNSRYGQTDRQG---QSSHYGQTDRAGQSSHY-DQSDRQGQSSHYGQ---T---D-RQ
GQN---------SPYDQTDRQG-------QNSPYDQTDRQGQNSRHGQTDR---------
------QGQSSH----YGQTDR--AGQSSH-----YDQSDRQGQSSHYGQTDRQGQSSH-
------------------------------------------------------------
------------------------------------------------------------
-------------------YGQTDRQGQNSRYGQTDR-----------------------
-----------Q------------------------------------------------
---------GQNSRHGQ-TD-----------------------------R----------
---------------QGQNSRHGQTDRQGQSSHYDQSDRAGQSSHYDQSDRQGQSSRYGQ
TER-AGQSYHYGQTDRQGMSSHYGQPDR--------------------------------
----------------QGQN-----------------SRYGQTDRQGQNSHYGQTDRQGQ
SSHY--GQTDRAGQSYHYGQTDRQGMSSHYGQTNRECQGYCSGQTDREGHSN--------
----------CYGQTDRQGLSSHHGQS---ETRKIGQNSYLQGREE-IS-----------
--R-DSYVEQPGSSGRLSQQTQGQEVA-RNQGQRFQSREGQQNSHQAWEP----EEDNQ-
-----------HHQHKLIAQI--KQEVP--HGYKEGEWQSCSG-----------------
-------------------EQGHRQTQAR--HEE--------------------------
------------------------------------------------------------
--------------------------R---------------------------------
------------------------------------------------------------
----QSHQA------EGEQACQ-----------------SWGRHGCEGQETPCKMQSRQN
HEEEQGHQRRDRQTHKDEQTRQ--------------------------------------
--RQERQTHEDEQTR-Q-------------------------RREKQTHEDEQTHQRQDR
QTHEEN-------QNY--------------------------------------------
------------QQKWDRQTLEEEARYQG-----------S-------------------
--------------------------------QDQQPYGI--------------------
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-------------------------------QQGRTNREKFHRNED--------------
----------------------SQRQNS-----QGGCSNLTLH------------PTQSS
GRPSRGEQGGSHPNKVA-SAPNALYNYVQEQKRN--------------------------
------------------------------------------------------------
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-------------

----------------MTDLLRSVVTVIDIFYKYTKQDGE-CGTLSKDELKELLEKEFRP
ILKNPDD-----------PDTVDVIMHMLDRDHDRRLDFT-----------E-FLL-M--
-V---------------F-K-L-A-M-A-C-NKV----LSR---K-YCK---A-------
SGSKKRRHGHQ----------HQKEESETEEE--------EE-------ETPR-----QK
SGYRHSSWREG-EEHGYA---SGGSRG---------------------------------
------------------------------------------------------------
----------------------------------------T--EKHSRGSNS-RRL----
----------------------------------------------------ER------
---QGQ-------------------RAREE------------------------------
----------------------------------------KVM-VVCHMDWGQMDMNQT-
--LRRQE----RMET--------------KS-MDLP---L--------------RVWEKT
-R------DKV--------MRVDIAIQVGVED---------------HK---M-------
------------------------------------------LLVLANQV---------D
-------------LE-IKEIS-----L--------------------AITT---------
-------------QVVNQEV---------------VEDKGMDVSQEVIPLNVLNLSL---
DPVATLLVKRDM------------------------------------------------
--D-------ID-----------NVAN--------------------------------R
RTVED--------N--RE------------------------------------------
------------------------------------------------------------
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-------------

----------------MPRLLRDVLCVIETFHKYASEDSN-QTTLTGRELKQLLQGEFGD
FLQPCV------------LYAVEKKLNLLNIDSNYIISFD-----------E-FVL-A--
-I---------------F-N-L-L-N-L-C-YLD----VQS-----LLS---S-ELRQ--
-ATKP-EKEKPDD------VNLQTAT---GD---------GQWTAG---TSLT-------
-----------QEER----------------MLPS----------------------RMA
SSSQLMPEEN----------------GAVGNNRVD-PWREAKTHNFSGEASEHNDP----
---KNQHL-------------------------------------------------QGD
-------EQSQEVAQDVPTTEDNEGQ-LKTKK---PMEESKQTSSPTE-RKG-QDKEVPR
ERD-EP----AREQSVS------KIRDQF---------------GEQEGNLG--------
--------------------------------------------TQSSPAQEATQRPSE-
-----------------DQ----------EVRIEK-E--K----------HSNTQEPPL-
------Q------------------GEDE-P-------------NSEHA---DMP-----
EQAAARKPSQTQ---KSTDPEDV--CRT----FDNQEPGKDAD------------QTPAE
------------TKN--SGETEDYGR---------------------TYEAQE-------
------------------------------------------------------------
------------------------------------------------------------
------------------KECETKDLQDQGGHRNG----SESSDMR--------DERKER
RGPETHRTAGQ-KE--------------------HDR---------------------KT
RPLVL-------------ETQTQDGKY--QELQGLS-------KSKDAEKGSET------
-----------------------------------------QYLSSEGGDQP-----HPE
L--------------E-------GA----A-VSGEEAEHTEEGTAEAFVNSKKAPAAEGT
LEAKE----------KTRD-----------------------------------------
--------------------------------------------LAPLEK-QSAGENRRV
TKTHDK--PVEEEDGYQ-----------------------------------REDPESPI
TQNDEGSSETPNSLASEEGNSSSKTG---------------E------------------
--------LPMQGDSH------------------SQGYPHGESV---------QGDHNNN
PGT---------------------------------------------------------
------------------------------------------------------------
---------------------------------------------QRQGTPGEKNRAQET
V------VLAVR------------------------------------------------
-GEDIQLTEDQEQPAREKHK-S--------QGSG-----T-KGPSAAVEPNGHPEAQ---
---ES-TRD--ENRKSLEIEITGTLDED--FTDQLSLMQLPGKGE---------------
-------------------SRNKLKVQGPSSKEEKGNTPEAQDTLLKRLDEDNSASP---
--QIQLETEE-------PVTL-EEEDESPQELSGEGDSQQSPTKK-EHNSSVSWSSLKKQ
MQRDQEPHSVEKSTVHSSPLYQYLQQKILQETNINQE--------------------EHQ
K---------------------------------QVQIAQASGPG---------LCG---
-VSLTSEISDCSVFFNYSQATQ---------------PYTRGLPLDESPAGAQETPAPQ-
----AGHPQRERLVPQREASTT----------------------------------K---
-----------------------------Q------------------------------
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-------------

------------------------------------------------------------
--------------------------------------LD-----------T-LLV-Y--
-I---------------F-I-L-S-H-F-L-ILK----DQK---E-NLP---I-------
SGHKHRKHSHH----------DKHEDNKQEEN--------KE-------NRKR-----PS
SLERRNNR-----KGNKG--RSKSPRETGGKRHES-----------------------S-
-SEKKERKG------------------------YSPT-HREEEYG-KNHHNSSK------
--------------------------------------------KQKNKTEN-TRLEDNR
K--R-----------------------LSER-------------IEEK----ED-----N
EEGGYD-------------------YENTG------------------------------
------------------------------------------RMTQKWIQSGHIATYYTI
QDE--AY-----D----T---------TDNLLEENKIYER-----SR-------------
------------------------------------------------------------
------------------------------------------------------------
-----------SSDD-KSSSQ-VNRSR--------------------HENTSQVPLQES-
RTRKRRG--SRVSQ----------------------------------------------
------------------------------------------------------------
-----------------------DRDSE-GHSEDSERH-SGSASRNH-------PG----
--SAR--------Q--QSRDGSRHP------R-SHDE-----------------------
---------------------------------------D--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----RASHGHSA------DSSRQSG-----------TRHAETSSRGQTAS---------
SHE---------------------------------------------------------
---------------------------------------------QARSSPGE-------
----------RH-GS-------RHQ-----------------------------------
-----------------QSADSSRH-S-----A---------TGRGQAS-----------
------------------------------------------------------------
-SAVSDRGP--RG---------------------SSGSQASDSEGHSENSDTQSVSG---
-------------------------------HGKA-------------------------
---------------------------GPRQQSHQ-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------ESARGRS-----------------------
-------GERSGHSGSFLYQVSTHE---QS---------------------DSAHGRTGT
------------------------------------------------------------
-------------------------------------------------STGGRQGSHHE
QARD-------------------------------------SS--RHSA-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------SQEGQDTIRGHPGSSRGGRQGS-------
HHEQL----VNRSGHSGSHHSHTTSQGR-SD----------A-------------SHGQS
-GSRSA--SRQTRNE-----EQ---------------------SG--------DG-----
----------SRHSGSRH------HEASSQ---------------------------ADS
SRHSQVGQGQSSGPRTSS---------------------------HQGSSVSQD------
SDS---------------------------------------------------------
------------------------------EGHSE-D-----------------------
-SERWS-----------GSA-----------S----------------------------
-----RNH------HGS----AREQSRDGS------------------------------
----------------------------RHPSR---------------QP----------
---------PDTQAFG--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------RGQ----
------------------------------------------------------------
------------------------------------------------------------
----------------------ASSAESE------------------TVAHEGP------
-V-------VVSGHSEESDTQSGQAMDQDGPHQQSHQE----------------------
------SHR-----TDWSGKVWTF-------------RVF--------------------
----------------------S-------------------------------------
------------------------------------------------------------
--------------LYQVSTPEQSESAHGRTYDST------------GRDKGSHHEQA--
--TQTVQALSVPEK--EGQDT--------------IRGHPRCQAEEEGRDPTMEQSV---
-------------------------------------------------DRSGHSVSITG
HTTSQGIR--------ILSASRQTRNNEQSGDGSGTQGHVTMKLPLGLTALETHRCVRNN
HRGPV--EQAGTRDP-------------VLARTSSRE---------VVCV----------
------CFRNHHGSSREQSRDGSRHPIPSRRQSRSRALC----------------RQLQT
I-----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--RHSSHRVFPLVDRLVIPMNSSLADSSRH----SGI---GQRTSF-ICRQRQWTPR-VS
GSQAIDSEGHSEDSDTQSS------VIHGTSWAHQQSHKESARGQSGKALDVQAL-----
-EEDKDPTPF----VDTRGRN---------------------------------------
---------------PTHEQSVDRFIANQVPSQPH---HTPG-------------KQAQQ
RNEEQS-------------------------------------------------GERL-
----------------QALRVGQGESAVSKTSRRRDPVLSGQGQLRDTQKTLRGSLSLAS
RN----------------------------------------------------------
------------------HYG-------SAPREQSRHGSRNPSQSWAL-------AESSR
QFRH--------------------------------------------------------
------------------------------------SSRRT-SSHGQACSH---------
--PRNTARSSRGERHGS-RHQQSADSSTDSGTGGRQAFICS----R--------------
----RQDSDTQSVSATDRLGPRQQSHQESTRGHVRGNLDVQG------------------
----------------------LSSTSL-----SPPM-DGQGPAL-GRQRSRHSR-----
-----HETTDIISCHTRVK-------------------------------------PEEE
WQGSHYEQPRS------HHRNHTH-----------------------------VPGKSNA
SM-------AVR--SRGHNQADGSRHSGSVTMKHS-------------------------
LSGRSSRTLARWSGGQS----SW--------GQATSREPGSSGH--SEDSAEVGLGL---
---PFQKPSWHLLSRSRKMALQTPGSIQEEQAGHEHS-----------------------
---ADSSRQSGHYHTESSFSGQACAHPMNTQDSSAGGRHGSHTSSQPDGSRHFRHWARTQ
LHLAVRDRRQRGPVVIQASDMTGHSEDFRH-----------------------------H
------SHCRPRTGWPISRSTK-SPHVAGHGK----------------------------
------------------------------------------------------------
--------------------------------------VGRSGSF------PLPVRQRS-
------------------LHEQASDSPPGTQVPSERSGH----HY--ATRWSSSGGGSDT
TMSHWIDRSGHSGSHHIRRRL---------------------------------------
----------------------------------QALRSR--------------------
---------ITHEASSRPNS-----SGPGTIRGLW----------PRESTSDTQQDSERW
YWVCFQKIIM-----RSARSIKRMAPD---------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------NPRSQ----------
---SRKTGRLVMG--------------------------NLCRD----------------
--------------------------S---------------------------------
---------------------------------------------SRQSGTLV-------
----------------------THKTSSGRTGL---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------PSSHEQ-------GRSS--GKE------
----NRHWIPATSRS---------------------------------------------
------------------------------------------------------------
---------------------------------ADSSRQLRHWARTSSSA----------
----------------------------------------DSADSGHRGTWL--------
-----------------------------------------------------AS--GP-
-----VTVSPHV--------AGRERSWTSGSFLYQGAT----------------------
----------------------------------------------------HEQAQP--
-----LEEGQERSLHEQARDSSRHSVSQEGQDTIHGHAGSSSGGRQGSHYE---------
------QLVDRSGHSGSHH--------SHTTS----------------------------
-----------------------------QGRSDAYHGQS--------------------
GSRSASRQT-------------------------------------------------HN
DEQSGDGFRH-SGSHHHEASSRADSSRHSQVGQGQSE--G---------------PRTSR
HRESSVSQDSDSEG HSEDSERWSGSA---SRNHHGSAREQSRDGSRHPRSHHEDRAGHGH
SADSSRQSGTRHTQTSSGGQAASS HEQG---------------RSSAGERHGSRHQQSAD
SSRHSGIGHGQASS-AVRDSGHRGYSGSQAS----DSEG HSED----SDTQSVSAHGQAG
SHQQSHQE----SARGRSGERSGRSGSFLYQVSTHEQSESSHGWTGPSTRGRQGSRHEQA
----------QDSSRHSASQEGQDTIRGHPGPSRGGRQG---------------------
---YHHEQSVDSSGHSGSHHSHIT-SQGSSHASHGQSGSRSASRTT---R-ND EQ-----
--------SVDGSRH-----------------------------SGSRHHEA--------
-------STHADISRHSQAGQGQSEGSRTSRRQGSSVSQDSD-----SEG HSEDSERWSG
SASRNHRGSAQE------QSRDG------SRHPRSHHEDRAGHGHSADSSRQSGTHHAET
---SSGGQAA-----------------------------------------------SSR
--EQARSSPGERHGSRHQQSA--DSSRHSGIRRGQASSAVRDSGHWGSSGSQASDSEG HS
EESDTQSVSGHGQDGPHQQSHQESARDRSGGRSGRSGSFLYQVSTHE-----QSESTHGQ
TGT----------STG--GRQ------GSHHEQARDSSRHSASQEGQD------------
--------TIHAHPGSSRGGRQGSHHEQSVDT--SGHSGSHHSHTTSQGRSDASHGQSGS
RSASRQTRND EQSGDGSRHSGSHHHEAFTQADSSRHSQSGQGESAGS---RRSRRQGSSV
SQDSDSQG H-SEDSERWSGSASRNQHGSAREQSRDGSRHPGSHQEDRAGHGHSADSS-RQ
SGTRHTESSSRGQAASSH----------------------EQARSSAGERHGSRHQLQS-
----------A---------DSSR---HSGI-GHGQASSAVRDSGHRGSSGS-QAIDSEG
HSED--SDTQSV---SAQGQAGPHQRSHKESARGQSGESSGRSGSFLYQVSTHEQPESTH
GQSAPSTGGRQGSHHDQAQDSSRHSASQEGQDTIRGHPGP--------------------
------------------SRGGRQGSHHKQSVDRSGHSGSHHSHTTSQGRSDAS-RGQSG
SRSASR------------QTHDK EQSGDGSRHSGSRHH---EASSWADSSRHSQAGQGQS
EGSRTSRRQGSSFSQDSDSEG HSEDSERRSGSASRNHRGSAQEQSRDGSRHPRSHHEDRA
GHGHSADSSRQSGTHHAQNSSGGQAASF HEQARSSAGERHGSHHQQSADSSRHSGIGHGQ
ASSAVRDSGHRGSSGSQASDSEG HSEDSDTQSVSAHGQAGPHQQSHQESTRGRSAERSGR
SGSFLYQVSTHEQSESAHGRTGPSTGGRQGSRHEQARDSSRHSASQEGQDTIHGHPGSRR
GGRQGSYHEQSVDRSGHSGSHHSHTTSQGRSDASHGQSGSRSASRQTRN EQQSGDGSRHS
GSSHHEASTQADSSRHS----QSGQGESAGSRRSRRQGSSVSQDSDSEAYPEDSERRSES
ASRNRHGSSREQ-SRDGSRHPGSSHRDT----TRHVQSS----PVQSDSSTAKEHGHFSS
LSQDSAYRSGIQS-RGSP----HSSSSYHYQSEGTERQKGQSGLVWRHGSYGSADYDYGE
SGFRHSQHGSVSYNSNPVVFKERSDICKASAFGKDHPRYYATYINKDPGLCGHSSDISKQ
LGFSQSQRYYYYE

----------------MPKLLESIVTVIDVFYQYATEYGN-CDMLSKEEMKELLVTEFHQ
ILKNPDD-----------PDTVDIIMQNLDRDHNHKVDFT-----------E-YLL-M--
-I---------------L-K-L-T-K-A-C-NKI----IGK---D-YCQ---A-------
SGSKQKNHSHQ----------HQEEQSKKETE--------NK-------E--------QK
GS---LSSSAG-ENDSYS---RGS-RGSNKSKSKK-----------------------L-
---R-------K------G-KEQ-------------------------------------
----------------------------------------S--SKQTTKSNS-SDHENSE
------------------------------------------------------------
-----D-------------------YEQGQ------------------------------
----------------------------------------HES-GFSNSSGNGRP-----
----------------SS-----------RKASGFPQPGS--EPGQ-SSSSSTKGSGECY
SSGNGKHGSSSGGSAVSGSGHSNTYGKQGTGSRHSSSNRRSRS-------------TSR-
-----------------------------ESSGSQ-EYSSGSSEEPGFTHG-SGRKNSST
-------------CG-KNGSY-----S--------------------GQSTG--RHQQG-
F-----G--SSHELESGQ------------------------------------------
--SITSANHGSH------------------------------------------------
--SNQSSCSGTR-----------ECGS--------------------------------S
ESSMK--------K--THVSGSGHS------S-STGK-----------------------
---------------------------------------YTSTSG---------------
-------QN-YN----STRQGC---GQ---------------GKSSGSEQY---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------GASSGQS-
----SGCSSGQSTRYGE-QGSGSRNSS-------TQSRGRSTSRESS-TSQQFGS-----
-------G-------SGRSSGFSQGG-----------SGQGRSSRGGQQ-G---------
S---FSGQT-----------E---------------------------------------
------------------GSQQH---G----------S------CCGQSSGYG-------
----------QN-EY-------GSGHSASSGQQGSH-----YSQSSSYGTHNSGGSPSS-
SQ----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------RGH-----GS------------------
------------------RSGRSSG-----------------------------------
------------------------LGQYGSP------S----------------------
------------------------G-----------------------------------
------------------------------------------------------------
-----------------------------------------QTS----------------
---------------SSTRQ----GSGQGQASGSGRY-----------------------
-------GASSGQTSGCG-----S----------------------GQSTRYGEQ-----
----------GSGSRNSSTQSRGRST-----------------SRES-----------S-
TS----QRYGSGS------GESSGFSQGGSGQ----G-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------RSSRGGQQG--------SFSG-QTSGR--SQHQS-----G
SRH--GSGSG------------QFPISGQQGSHHGHSSSSGTHNS-GSSQSSSTQW----
---------------------------------------------SHGSGSEQSSGLGHY
-GSTSGQ---------TASSTRQGSGQGQASGSGRCGASSGQTSGCGSGQSTRYGE-QGS
GSRNSSTQSRGRSTSRESSTSQRYGSGSGGSSGFSQGGSGQGRS-SRGGQQGSFSGQTEG
SQQHGSCCGQSSGYGQNE-YGSGHSASSGQ--------Q--GSHYSQSSSYGTH------
NS-GGSPS----------------SSQRG---HGSRS------------------G----
----------RSSGLGQYGSP---------SGQTSSS-TR--------------------
-QGSGQ-----------GQASGSGRYGAS--SG---------------------------
------QT------SGC----GSGQS----------------------------------
------------------------------------------------------------
----------TRYG----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------EQGSGSRNS-----STQS-R---------GRSTSRES-S
---TSQR-----------YGSGSGESSGFSQ-----------------------------
-------GGSG-QG--R-----------------------------------SSRGG-QQ
--G--------SFSGQTSGRSQHQSGSRHG-SGSG--------QFP-ISGQQGSH--HGH
SSSSGTHNSGSSQSSS-----------TQWSHGSGSEQSSGLGHYGSTSGQTASSTRHRS
GQGQASGSG--------------RCGASSGQTSGC-------------------------
--------------------------------------------------GSGQSTRYDE
QGSGSRNSSTQSRGRS--------------------------------------------
TSRESSTSQRFGSGSGGSSGFSQGRSGQGRSSR-GGQQGSFSGQTEGSQQHGSCCGQS--
--SGYGQNEY--------------------------------------------------
------------------------------------------------------------
----------GSGH--SASSGQQGSHYSQSS-----------------------------
--------SYGTHNSG-----GSPSSSQRGHGSRSGRSSGLGQYGSPSGQTSSSTRQGSG
QGQASGSGRYGAS-----SGQT--------------------------------------
----------------------------------------SGCGSGQSTRYGEQGSGSRN
S-----STQ---------------------------------------------------
-----------------SRGRS---------T----------------------------
---SR------ES-----------------------------------------------
-----------------------------------------------------STSQRYG
SGSGES-SGFSQGGSGQG--RSSRGG--------------QQGSFSGQTSGRSQ------
--------------------------H--------------------------QSGSRHG
SGSGQFPISG--------------------------------------------------
-----------------------------QQGSHHGHSSSSGTH----------------
------------------------------------------------------------
----------------------------NSGSSQSSS------TQWSHGSGSEQSSGL--
-GHYGST--SGQTASSTR----------QGSGQGQASGSGRCGASSGQTSGCGSGQSTRY
GEQG--------------------------------------SGSRNSSTQS--------
------------------------------------------------------------
------------------------------------------------------------
------------------------R-----------------------GRSTSRESSTSQ
R-FGSGSGGSSGFSQGRSGQGR--------------------------------------
----S-----S-------------------------------------------------
RGGQQGSF----------------------------------------------------
-----------------------------------SGQTEGSQQHGS-CCGQSSGYGQN-
----EYGSGHSASSGQQGSHYSQSSSYGTHNSGGSPSSSQRGHGSRSGRSSGLGQYGSPS
GQTSSSTRQ-GSGQGQAS----------------GS------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---GRYGASSGQTSGCGSG---QSTRYGEQGSGSRNSSTQ------------------SR
G----RSTSRESSTS-------Q-------------------------------------
------------------------------------------------------------
-RYGS-----------------------------------------------------GS
GESSGFSQGGS------GQGRSSRGGQQGSFSGQTSGRSQHQSGSRHGSGSGQFPISGQQ
GSHHGHSSSSGTHNSGSSQSSSTQWSHGSGSEQSS----------------GLGHYGSTS
GQTASST--RQGSGQGQASG---------SGRCG--------------------------
-------------ASSGQTSGCGSGQSTRYGEQ---------------------------
------------------------------------------------------------
----------------------GSGSRNSSTQSRGRSTSRESSTSQ--------------
---------------RYGS--GSGGSSG---FSQG---G--------------SGQGRSS
RGGQQGSFSGQTEGSQQHGSCCGQSSG--YGQ---------NEYGSGHSA----------
-----------------------SSGQQGS---------HYSQSSSYGTHNSGGSPSSSQ
RGHGSRSG-------------------------------------------------R-S
S------------------G----------LGQYGS-PSGQTSS----------------
----------STRQGSGQGQAS-----------------GSGRYGASSG-----------
--QTSGC-----------------------------------------------------
------------------------------------------------------------
--------------------------GSGQSTRYGEQGSGSRNSSTQ-----------SR
GRSTSRESSTSQRY------------------------------------GSGSGESSGF
SQGGSGQGRSSRGGQQGSFSGQTSGRSQHQSG---SRHGSGSGQFPISGQQGSHHGHSSS
SGTHNSGSSQSSSTQ------------W---SHGSG--SEQSSGLGHYGSTSGQTASSTR
QGSGQGQASGSGR--------------------CGASSGQTSGCGSGQSTRYGEQGSGSR
NSSTQSRGRSTSRESSTSQRYGSGSGGSSGFSQGGSGQGRSSRGGQQGSFSG--------
-----------------------------QTSG---------------RSQHQSGSRHGS
GSGQFPISGQQGSHHGHSSSSGTHNSGSSQSSSTQWSHGSGSEQSSGLGQY---------
----------------------------------GSPSG---------------------
------------------------------------------------------------
--------QTSSSTRQGSGQGQASGSGRYGASSGQTSG---------CGSGQSTRYGEQG
SGSRN----SSTQSRGRSTSRESSTSQRYGSGSGESSGFSQG------------------
--GSGQ-------GRS------SRG------GQQGSFSGQTSGRS---------------
------QHQSGSR-------HGSGSGQF----PISGQQGSHHGHSSSSGTHNSGSSQSSS
TQWSHGSGSEQSSGLGHYGSTS--GQTASST-----------------------------
----------RQGSGQGQASGSGRCGASSGQTSGCG-----SGQSTRYGEQGSGSRNSST
QSRGRSTSRESSTSQRFGSGSGGSSGFSQGRSGQGRSSRGGQQGSFSGQTEGSQQHGSCC
GQSSGYGQNEYGSGHSASSGQQGSHYSQSSSYGTHNSGGSPSSSQRGHGS-RSGRSSGLG
QYGSPSGQTSSSTRQGSGQGQASGSGRYGASSGQTSGCGSGQSTRYGEQGSGSRNSSTQS
RGRSTSR--ESSTSQRYGSGSGESSGFSQGGSGQGRSSRGGQ----------------QG
SFSGQTSGRSQHQSGSRHGSGSGQFPISGQQGSHH--GHSSSSGTHNSGSSQSSSTQWSH
GSGSEQSSGLGHYGSTSGQTASSTRQGSGQGQASGSGRCGASSGQTSGCGSGQSTRYGEQ
GSGSRNSSTQSRGRS---TSRESSCSQHDVSGSGESSSFSQHRSCQ--------------
--------------------SQASHNGQCGPFSGQSSGHIQHGPCFGQTEGSFQSSNCGQ
QGTTSY--QSSGFDQQRSG----LHQSFPCSNHEST--SQEYSSFGSCVSGSGECSGFGN
QVSRP-SQSTYEHHESNRNQSSGYRQYNTA----SGQSYCG--------------GQCGS
NSNQ--------------------------SSSYREQGLGSNQSSQYGQYRCPSSHYSSQ
SQHGVGCSHGFNTGQYGSGSY------PSSNSRQNCPGSGLCPTSEQYGSGSCQSFSPGS
CGSGYGQYSNFEQPQ-SN-------------------------RRCGNQWES--------
----------GCSSSNCNENQSIRVHRQVE---------------TSSGCGFGQFS-SQE
QIRSDTTG-KLSLCNVDNRQGNCKYQIIKGSNFG----MRNTVSGPHSFNSSTPLYEYVQ
EQRR--------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------

----------------MSPLLRSVIDIAEIFDHYASHSCD-GASLSKKDLKNLLERELGT
VLQRPQD-----------PETVDLTLALLDRDSNGRVDFN-----------E-F-L-L-F
-L---------------F-K-I-A-Q-A-C-Y--Y-A-L-D-Q-T-SG--L-D------E
K-RN---------------V-S--QD-RRQ-ED-Q-R-----------------------
-------------------------------RF-------------------------EP
QDVQRDEERG-----HQSRQKRHE----QEE--RT-DEQR----KRQE-RLEQE------
--------------------------------------------------EQRRELQEL-
-------------------------------------EERLAEKEPLSWSQGPDAEEFSE
EENLRE----RQELKSKDQ---------TE------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------ERRL--------QKRR-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------R--EEV------SD-----
------------------------------------------------------------
-----------------------------------------------------------P
QL----------------------------------------------------------
------------------------------------------------------------
-----R------------------------------------------------------
------------------------------------------------------------
-------------------------RDAQLR-----------------------------
----------------------------------------RD-PQLRR----EQELV---
---------------AE-EE---EQT---------------RL-----QEPDDSFTRRWQ
QQLESE-------------------------------AEARQNK---VYSR---------
PRR-QEAE-----ERQLREQGQR-------------------------------------
------------------------------------------------------------
-------------------------RDLRRQRLAE-------------------------
---------------------EER----------LEQEQRFRERDG--------------
--EEQSFR--EEELQRAELQDSLLEER------QR------RRRDASRSRQ--LQEES--
-----------QRCHTRYA-------EP------SQRQQSGEELR-EERL-----LQEE-
--------------------AQRRQQRDRKYLREEERL-QQQEEERL-------------
------------------------------------------------------------
-----------------------------QQ-------------------------EEER
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------LQQQEERLQLEEERLQRREEQ--------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------LQREKRHLQRERQYQEEDLQQEEER
LQQEE------------------------ELLQQEEERLQ---Q------ERRRLQRGRQ
Y------------------------------------QEEDLQRLRDVDQRRDLKW----
QWQPEKENEARRHRLFSKRRQDEERTRQLED-SLEQERRLRQDRRPLREEAG-----EKR
ELEQETRRRLQRDRQLLEEEQ----LQREH---QREARRRDENIQEEEQLLRD-SR---R
RPQERDAKFLEEEKQLRKRRE-----------------------EHRRRQEQERQFQEEE
ELRHQEREKELRQERGRNSCEEQELRQQLEADQRRQELREEEQRRQQRDRRVRQEEELRQ
ELR------------------EEEQRRQQRDRRVRQEEELRQELR-----EEEQ------
----------RRQQRDRRVRQEEELRQELREEEQ----------------RRQQRDRRVR
QEEELRQELREEEQRRQQRDRRVRQEEELRQELREEEQRRQQRDRRFRQEE-ELRQELRE
EEQRRQQRDRRFRQEEELRQELREEEQRRQQR------------------------DRRF
RQ--------E-EEL---------------------------------------------
-----------------------------RQELREEEQLRHQ------------------
-ERDRKSRGE--------------------------------------------------
-----------------------RELRQ-----ELEEEQFQGRKFLREQELRRDRKFREE
EQLRHQKCDRK-FREAE-RRQ--------------------------------------E
LEEEQLRHQERDRKFREA-ERRQELEEEQLRHQKCDRKFREAERRQ-ELEE---------
-----------------EQLRHQERDRKLREAERRQ--------------ELEEEQLRHQ
ERDRKLREA--ERRQELEEEQLRHQERDRKLREAE-RRQELEEEQLRDRKLRA---EEQL
RGERE-------------EERRRGQECDRKFRREQEFSQELEEEQ----PRDRK------
------FRREQELRRDRKFHEEEERRQQL--EEEQLRHQERDRKFREAQ-----------
-------RRQERDRKFHEEERL-QELEEEQLRDRKLRVEEQLRREQEEER----------
---------------RQFRQELEEEQPRDRKFRREQEL--------------------RR
DRKFHEEERLQELE---EEQLRRQERGR-KFLEEEERRQ-----------------ER-D
RRFRGEPELRKEREGQQRQQLRFE--------EQK-------------------------
-----RRHQELEQQLRQERDRKFREEKQLRQ--EREELQL----RRQKRDGQYPAEE---
-----------QFARDKIRR-QEQEQRQEEEQKRRQELERKFQEEQ-IR-----------
-----------------------------RQAEQRRRQILE-----SGTRQFANVPV---
-------------------RSSPLYEYIQEQRSQYRP-----------------------
------------------------------------------------------------
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-------------

----------------MPQLLRNINGIIEAFRRYARTEGS-CTALTRGELKRLLEQEFAD
VIVKPHD-----------PATVDEVLRLLDEDHTGTVEFK-----------E-FLV-L--
-V---------------F-K-V-A-Q-A-C-FKT----LSESP-EGACS---S-----QE
SGSL-----HS-G----AWQELSE-GQRSGTEV--GRAGKGQHYEG--------------
-------SS-------------------------------------------------HG
QSKQP-----------SRGQSR---------------PGAQTQG----------------
------------------------QATGSAWVSSYDR------------------QAESQ
SQERT-SPQIQCSGHTEQTQRAGEGKRHQTTQ------M--------------R-----P
EREP-----QTREQDRAHQTSETV-TGSG-------------------------------
--------------------------------------------TQTQA--GATQTVEQD
SSHQTGRTSSQTQEATNDQNRGI----------------E--------------------
-----IHGQGRSQASQ-----AVTGGHAQAQ-------------A---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------GSHT-----------------------------------------------
------------------------------------------------------------
---QTPTQTVEQDSSH----------------QTGSTSTQTQGSTNGQNSGTEIHGQGRS
Q---------------TSQAVT---GG--HA----------QTQAGSHTQTV--------
-----------------------------------------E------------------
------------------------------------------------------------
----------------------QDRSQTVSHGGAGE------------------------
---------------------------------------------------QGQTQ----
MQPGSGQKWTQVSNPEA-GE----------------------------------------
---------TVPG-------------------------GQAQTGASTESGRQEWSSTHPR
HNV----------TEGQG-----------------------DIQPT--------------
-------VVGEEWVDDHSRET---AIFRLDQGN----LHT--------------------
------------------SVSSAQGQDAAQ------------PE-EKQGIT-ARE-----
----------L--------------------------YSYLRSNKP--------------
------------------------------------------------------------
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-------------

----------------MTELLNSILTVIRVFQKYAKENGD-STSLCKEELKQLLLAEFGD
ILRRPND-----------PETVETILSLLDRNRNEHVDFH-----------E-YLL-M--
-V---------------F-Q-L-A-Q-A-C-YHR----LDN---E-SYG---D-------
RTSQ-QERKQE-G-----TQGHTFPTN-TGR---QH----RKRHEGERQ-----------
-DSCHS-QSEKQSQDTHQ--DQ-SERQDRDSR--------------------------YS
QSERLDRDS--HY-GQSEGQDRDS------------------------------------
---HYGQTERQ------------GQDSSSGQRLS-------------NKSGS--GNPERQ
G--YV-------F-------------ALNQYE------KQ------LQ-----------D
SHCGQS-----------------DRLGQQS------------SYGQ-SGRLR--------
--------EDPQYSHTN----------Q-----QESGSYNEQSGRLGQ-ESGYGQRNRQE
LESHYGQTDRQGLSTHCSQTRPD-------------------------------------
-----------------RQGQSYHYGQTDRQGQSSHYGQTDRQGLSSQY---GQTDRQGL
SSHYGQTDRQG---LSSQYGQTDRQG-L--S------S-----------HYGQMDRQGQR
-------------------S--HYD-------------------------------QT--
---DR----QGLSSQYGQMDRQG--------------------------------LSSHY
GQTDRQGLSSQYGRMDRQGQ----------------------------------------
-----RSHYDQ-------------------------------TDRQGLSSQY-G--QTDR
QGQSSHYDETDRQG---LSSHYGQTDRQGLSSQY-GQTDRQGQSSHYDE---T---D-RQ
DLS---------SHYGQTDRQG-------LSSQYGQTDRQGQSSHYDETDR---------
------QGLSSH----YGQTDR--QGLSSQ-----YGQTDRQGQSCHYDETDRQGLSSH-
------------------------------------------------------------
------------------------------------------------------------
-------------------YGQTDRQGLSSQYGQTDR-----------------------
-----------Q------------------------------------------------
---------GQSSHYDE-TD-----------------------------G----------
---------------QGLSSHYGQTDRQGLSSQYGQTDRQGQSCHYDETDRQDLSSHYGQ
TDR-QGLSSQYGQTDRQGQSFHYDETDR--------------------------------
----------------QGLS-----------------SHYGQTDRQGQRSHYDQTDRQGL
SSHY--GQTDRQGLSSQYGQTDRQGLSSHYGQTDRQGQSSHYDETDRHGLST--------
----------RYSQTDRQGVNSQYGQS---ETGETRQNRCFQGSEG-AS-----------
--R-DSHVEQSGRPGRPSQYTQGQEVN-RNQGQRFQTREGQQNSRQAWES----EEDS--
-------------QHKLVAQI--QQERP--PCHSGRDWQSHSG-----------------
-------------------EQGHRQE----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------TPRETWDRET
HEDKQTPQRRDRQTHEDQQTGQ--------------------------------------
--RQDRQTHEDEQTR-Q-------------------------RRDRQTHKDEQTHE----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------DEQTRQRQDRQTHEEDQN-------------------------------
---RRQQQDWQTHKDKERYQESQYRQSHGT------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------QEGCANREKFHMNED--------------
----------------------GQSPSS-----QGRCSDLAFH------------PTQNA
GRPQRREQGGSHPIKAT-IAPNPLYDYVQEQKGVWH------------------------
------------------------------------------------------------
------------------------------------------------------------
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-------------

----------------MSHLLSSILTIIDVYYQYTNKDQD-CSTLCKRELKELLEKEFRP
ILKNPDD-----------PDTVEVFMHMLDRDHDRKVDFI-----------E-FLL-M--
-I---------------F-K-L-T-M-A-C-NQS----IGK---E-YCQ---A-------
SGSHKKHSSHH----------HQEEQSESEEE--------EE-------DDSS-----NS
------SQSAG-EKPKSH---TGQSKKTRKVRHRS-----------------------KS
SSPG-------N------G-KLSH----SS------SPGHSDIHE-RKHHSSRL------
---------------------------SHPKG--------S--EKKRNGSSS-SDLEEKR
H--------------------------KSNI---------------------SP------
---SRK-------------------YGGEE------------------------------
----------------------------------------HEL-ASEWLVSDGRKRFAS-
-----S-----SGVLSCK-----------LKSKGQKSNTN--------------QSEECR
EQ------RQRYKSCQTGSYKQAYSQSDGCGRQRRCS-------ENCER---KGQKTSGQ
SQNCGGQ---EH---WSYSW---------QSSSCE-QQRSGSNQSSNSSQCGTGSDQSSS
-------------CR-HQSSG-----S--------------------HQSSS--RSQFG-
S-----G--SGQSSSSGQQ-----------------------------R--------SGS
HQSSSSGQSGAG------------------------------------------------
--SGQSSKYGQH-----------GSSS--------------------------------N
QSSNK--------G--QGRSGTGQS------S----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------TSQQHGK-----
-------G-------SGQYSRYDQHG-----------SGSSQSSSYEKYG----------
S---YSGQS-----------S---------------------------------------
------------------TSHHH---G----------S------GSGNSSTYG-------
----------KG-RS-------GQGQNNTNAQQGSG-----YSGSNYQRGDSAGNLVSEN
KQRTSRK-----E------Q-DSAH-S-----A---------SYQHQSTDSR--------
------------------------------S------------R------R----REGVG
NRQEQDSSR--HGRSGETQDSDSRSRSR------------RK------------------
------------------QGVDSRQEQDTSRHGRSEQR--------QSSD----------
---SR--------SREIE--------ESGR-SQVH-----DS------------------
------------------SR----------------------------------------
------------------------QGVSGQR------QSRDST----------------S
RQ-RSGSERQEQ----DSG-HSVSGQRQSTDSTSRGRQGVGSR-----------------
-------QEKDSSRHGR-------------------------------------------
-----------------------------S-----G-K--RQSSD-SRH-----------
-------------EVSSQRQS--RDSTSRQRSGSGRQ-----------------------
-------EQESGNSV-SGQRES-----------------------------ID-------
------------------------SR-----------------SRRR---------QGVS
SRQ--EQ-DSSR--------------HSRSGE----SQSS---------DSRSREREESG
-RRHGVSG------------------QRQSTDSR-------------S---RGRKG----
---------------IGNRQEQ--------------------------------------
------------------------------------------------------------
-----DSS--------------------------RHGRSG-------QR-----------
------------------------------------------------------------
----------------------------------------------------QVNDSSTG
HSHRSKL---G-------------------------------------------------
--------------------------------------------------QERD------
-------SSE------------HSLSHHT-------------------------------
------------------------------------------------------------
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-------------

----------------MPKLLQGIVTVIDVFYQYATQHGE-CDKLNKEELKELLENEFHE
VLKNPDD-----------PDTVDIILQNLDRDHNEQVDFT-----------E-YLL-M--
-V---------------F-K-L-S-R-A-C-NKI----VGK---D-YCQ---A-------
SGSTHKDHSHK----------HQEEQSDTEEE--------G----------KG-----QK
SSSIYSSSSAG-EYGSFS---RDS-RG---------------------------------
------------------------------------------------------------
----------------------------------------S--IKPKS------------
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-------------

--------HSLSELAKMPRLLRGVLCVMETFHKYARED---KATLTHRELEQLLQGELAD
SIQPHV------------IHAVQRNLNLLGIDSADTISFD-----------E-FVL-V--
-I---------------F-N-L-L-N-L-C-YFD----MQS-----LLN---S-EPRQ--
-VLNP------HN------VDLQVTT---RN---------GQQTGG---TLPT-------
-----------QDKV----------------V---------------------------T
SSAELSTEES----------------RVVGRHRGD-PQGGSKTHNLPGETSEQNDV----
---KIQQL-------------------------------------------------EAD
-------EQNQEAAPKVLATEDNGAQ-LKTSE---SLSGSEETSSPTK-REA-QTREIPR
EGD-KP----AREQRGT------KTRDQQ---------------GEEERNLK--------
--------------------------------------------QQ----QETTQRPSE-
-----------------NQ----------EVAAKK-GTKK----------HSKSQGPPL-
------Q------------------GV-E-P-------------RAERA---DLP-----
ERTSARKPSLTQ---KSADPEDG--SR---------------------------------
-------------------------T---------------------SSEAQKPPAHE--
------------------------------------------------------------
------------------------------------------------------------
------------------REHETQKLPVHG----V----SETLGIR--------AERKEG
GSLQPHGSARQ-KE--------------------QQR---------------------KT
QPPAL-------------EARTQDEKD--QKLQGST-------NEKDAEKGSES------
-----------------------------------------QDLISEDRNQN-----SPE
I--------------E-------GK-------------YPEESPEEESVNSKNGPAAKGT
PRARE----------RTEE-----------------------------------------
--------------------------------------------SVPPEH-QPGAENGGV
VETCDN--PAAADDGCG-----------------------------------DEEPESQV
TQDEEGTSGTPHGLAPEEGDQSSETG---------------G------------------
--------LPVPGEPQ------------------GQEDPHREPE---------KGSHNDN
PDT---------------------------------------------------------
------------------------------------------------------------
---------------------------------------------QKQEAPGERNRAQEV
A------VLSAE------------------------------------------------
-GEGVQLAEGQE-PAARECR-S--------QGSG-----L-KGPGAAVQPDGHSETQ---
---ESTDRG--ENTKSLRTDISAALAAD--FSDQCSLMQLPEKAD---------------
-------------------GRRQLKIQGPRTREEEEGASETQEALLKRLDEHNSASP---
--KTRFETEE-------PAIL-EEEDGHPHQLAGGHDDQQNPTKK-DYASAVPRPGLEQR
MRTAQKPSSRETATVRSSPLYQYVQEKLLEQTHITQE--------------------ELQ
N---------------------------------QDKTAHTLDQE---------LQKIQP
RAFLTNKNSDCPAFFNHSQASQ---------------QLTREFLPDEDQTSAP-----WA
SEDKQGRPQREEPVPHRE------------------------------------------
------------------------------------------------------------
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-------------

----------------MPKLLNSILNVSKVFQKYAEHHGK-HALLSKEELKQLLLTEFGD
ILRRPND-----------PDTVEIILEHLDRDRNGYVDFQ-----------E-YLL-L--
-V---------------F-Q-L-V-Q-A-C-HRK----LDS---K-VCG---A-------
GTSSQKEQGQK-G-----MQSHKFPEN-MGR---QD----GQ------------------
-SSHHS-WSEGQSQDVQH--DQ-SQRQDKDSH----------------------------
--------------GHSERHDTDSHYGQSERQDRD---SHHGQSEKFHQDSYHSCSERQD
TDYSSDQSE------------IDNQHSSSGQSLSY-------------KSSN--DQPKSQ
G--YI-------F-------------ALNQSE------NP------AQ-----------V
SHYGQS-----------------KTFRRQS------------SHGQ-SGRFR--------
--------QDSYSSQTS----------R-----QQPGSYEQY-GKLHQ-KSGNSQTDRQA
QNSHYGQPDKQGNSFQYGQTD---------------------------------------
-----------------GQGQSFHYGSQ--------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
-----------------GQSSQQGQTGNQDQSSHRQTYHQGQTGSQDQSSCWHQTDRQ--
TYHQ--GQT------------------------DRQGQSSQQGQ----------------
--------------TSREGQSYHCGQSGIGKTELQGQNRYFQGTDE-TR-----------
--R-HSYVEQSGGSGKLSQQTSREEVN-QTQRQRFQDRRDQKTHHQAWKL----EKDN--
-------------QHKLLAQI--QQEEP--HSHNEYDWQSQSS-----------------
-------------------EESH-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------WE-------EKEHPQ-----------------FWDRHSLEDQESLYEMQ---T
HEDEQSHQTKDTQTYVDKQNQK--------------------------------------
--RQHRQTHEENQDH---------------------------RHGRQTHEDEQNYERKDK
DQ----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------N--------------------------
---HHQQWNRQTHEENERYQGSQDR-----------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------FRSFPNKERFHKNED--------------
----------------------DQCQGS---------EGRHFH------------QTHRG
GRSQRREQQGNHSTKTA-NSPNPLNDYVREQAVYQY------------------------
------------------------------------------------------------
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-------------

----------------MPQLLRNINGIIEAFGRYARMEGN-CQVLSRGELKRLLEHEFAD
VIVKPHD-----------PATVDEVFRLLDEDDTGTIEFQ-----------E-FLV-L--
-M---------------F-K-V-A-Q-A-C-FKT----LSKSP-QGACG---S-----QE
FGSQ-----HS-G----ASQELGE-GQASATEA--RRVGTGLQQEG--------------
-------SS-------------------------------------------------QG
QSKQT-----------SRGQDR--------AR-----TQIQSQ-----------------
-------------------------D----NSSTHDR------------------QTEAQ
RQERT-SQQTQASGHEGQTQSM-EDKNRQTRE------S--------------R-----S
ESQS-----QTTQQDRAPQTGETK-TGTA-------------------------------
--------------------------------------------THTQA--GATQTVEQD
RSHQTKSTSKQPQESPHGQTREP----------------E--------------------
-----THGQDSSQTSQ-----VVTGQHIQTQ-------------SRS----YTKTVQQGR
SHQTGSTSVQTQ---ESPDSQTKGPK-----------------------------THRQD
SSQ---------------TSQVVTGG----------------------------------
-------HVQTQTGSY----TKT--------------VQQGRSH--------------QT
GSTSVQTQEFSDGQTKGPKT----------------------------HSQDSSQTSQVV
PGGHAQAQTG--------------------------------------------------
------------------------------------------------------------
----SQTQTMQQGINH----------------QTGSTSIQTQGSSDGQTRRPETHSQDSS
Q---------------TSQAVT---GG--HV----------QTEAGSHSQTV--------
-----------------------------------------E------------------
------------------------------------------------------------
----------------------QGISQSESHTGAGA------------------------
---------------------------------------------------QGQTQ----
TQSGTGQRWTHVSNFEA-RE----------------------------------------
---------SAPG-------------------------GQAQTRASVVTGRQEGSSTHSS
SSV----------TGGQG-----------------------ERQPP--------------
-------VVTSEWVDDITREL---VIERQD------------------------------
------------------------------------------------------------
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-------------

----------------MSPLLRSIFNITKIFNQYALHDCD-GTTLSKKDLKNLLEREFGE
ILRKPHD-----------PETVDLVLELQDRDRDGLIDFH-----------E-F-L-A-I
-V---------------F-K-V-A-A-A-C-Y--Y-A-L-G-Q-A-SG--L-N------E
K--EA-K-C-E-G-K-G-NP-L--QD-RRR-ED-Q-R-----------------------
-------------------------------RF-------------------------EP
QDRQLEERRL-----KR-----QE-----LE--EL-AEE-EELREKQV-RREQRLQ----
-------------------------------------------------------RREQE
E--Y----------------GEEEEL-QQRPK-------------------GREPEELLN
REQGFE----RQEQR--------------------ER-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------Q---------------------RLQVEQQQ
RQ----------------------------------------------------------
------------------------------------------------------------
---------------------R--------------------------------------
----G---------------------------ELR-----ERQ-EE-VQLQRRETQ--EL
QRE---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---RLEEEQQ----------------------------LQ--------------------
--------------------KQ--------------------------------------
--KRGLE-----ERLLE-----QERREQELRR--KEQ-----------------------
--------------------------------------ERRE-QQLRR----EQE-----
------------------EA---TQE---------------EI-----SERGESRTSSCQ
WQLESE-------------------------------ADARQRK---VYSR---------
PHR-QEQQ-----SRRQEQELPER------------------------------------
-------------------QQEQ---Q----------I---------REEVQS-------
----------LQEDQERQRLKQEQRYDQNWRWQLEE-----ESQRRRYTLY---------
-----AK-PAQREQVR----EEEQ---------------LRLKEEQLQREKRR--QERER
QYREVELQREEERLQREEEQLQ--------REEREKRRR--QEREKQYLEKVELREEE--
-QLQRQER---EK-----------------------RRQEREKQY----L-----EKVEL
-----QEEEQL--QREE-REKRRRQEREKQYLEK-VEL-R-EEEQLQREE----------
-REKRR-RQEREKQYLEKVEL-REEEQLQR----------------Q-------------
---------EREKRR-QERERQYLEKE---------------------------------
---------------------------LQRQEERLQEEEQLLREERE---------K-RR
-QERERQYLEKEELQRQEE-R-------------------------LQRQK-EQLQRQ--
-EREKRRQERERQYLEKVELQEEEQ--LQR--------------Q---------ERE-KR
RQERERQYLEKEELQRQEERLQREKEQLQREDRE----KRRQVRERKYLEEE--------
LQQEEDRLQREKQLL---------------------------------------------
----------REDREKRQYLEKVEL---QREEEQL---QRE-------------------
---------------------------------------KRRQERERQYREEELLREEER
LHR-------------------------------KEQQLQ---RE--ECEKRRRQELERQ
L------------------------------EEEELQRLDRKRQFR--------------
-DEDQHQNEVRNSRVYSKHRENKEKSRQLDD-SWVRESQFQQDRRPLQDEQE-----EKR
EREQEWRSRQKRDSQFPAEQL----LEREQ--QK-ETERRDRKFREEEQLLKG-QREEKI
RYLEEDRKFREEEQQLRR-----------------------LEREQQLRQERDRKFREE-
-----------------------------------------ELSRQERDRKFREEEQLLQ
ERE------------------E-QLRRQERDRKFREEEQQLRLLE-----REQQ------
----------LRQERNRKFREEQLLREREEQ-----------------------------
------------------------------------------------------LRLQEG
EPQLRQKRERKFHEEEQLLREREE-QLRRQ------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------ERDRKFREE
EQLLQEREELRRQER---------------------------------------------
------------------------------------------------------------
-EKFHEEEQLLQEREE--QLRRQERDRKFREEEQLLQEREEQ------------------
---------------------LRRQ-----------------------------------
------------------------------------------------------------
----E-REPQLRQERDRKFREEEQLLQER--EE-QLRRQERDRKFREEEQLLR-------
-EREEQLRRQERDRKFREEEQLLQERE-------------ELRRQE--------------
----------------------------REKFHEEEQLLQERE-----------------
-----------------E-QLRRQERDRKKFREEEQLLK-ESE-------EQLRRQER-D
RKFHEKEHLLREREEQ--QLRRQELEEVFSQEEQLRRA----EQEEEQRRQRQRDRKFLE
EEQSLQREREEEKRRVQEQDRKFLEQEEQLHREEQEELRRRQQ-----LDQQYRAEE---
-----------QFAREEKRRRQEQELRQE-EQRRRQERERKFREEEQLRRQQQEEQKRRQ
ERDVQQ----S------RRQ--------VWEEDKGRRQVLE-----AGKRQFASAPV---
-------------------RSSPLYEYIQEQRSQYRP-----------------------
------------------------------------------------------------
------------------------------------------------------------
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-------------

----------------MTDLLRSVVTVIDVFYKYTKEDGE-CGTLSKDELKELLEKEFHP
ILKNPDD-----------PDTVDVIMHMLDRDHDRRLDFT-----------E-FLL-M--
-I---------------F-K-L-T-M-A-C-NKV----LSK---E-YCK---A-------
SGSKKHRHGHR----------HQEEESETEDD--------EE-------DTPG-----HK
SGYRHSCWSVG-EEHGYS---SGHSRGTVKRRHGS-----------------------N-
-SKRLGRQG------------------------NLSSSGNQEGSQ-KRYHRSSS------
---------------------------GHSWS--------S--GKERHGSSS-GELRERI
N--------------------------KSHI-------------SPSR----ES-----G
EEYESG-------------------SG---------------------------------
--------------------------------------------SKSWERKVHGGLSCGL
ETS--GH-----E-SNST---------QSKIR-GQKLGSS-----CSGSGDSGRRSHACG
YS---------------------------------------------------------N
SSGCGRP---QN---VSSSCQSHRFGGQGNQFSYI-QSGCQSGINGGQGHGCVSGGQPSG
CGQ-----PESNSCS-QSYSQRGYGA----------------------RENCQ--PQNC-
GGQWRTG--SSQSSCCEQY-----------------------------------------
-----------------------------------------------G-------S----
-GGSQSCSSGQH-----------EYGSC-GRFSNSSS----SNEFS--------------
---KC--------G--QHGSGSGQS------T-SFEQ-----------------------
---------------------------------------HGTGL----S-----------
---QSSG---------FEQHVS---G-----------------SGQTCGQH---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------ESTSSQS-
------------LGYDQ-HGSSSGK-----------------------------------
-----TSGFGQHGSGSGQSSGFGQCG-----------SGSGQSSGFGQHGS---------
------------------------------------------------------------
--------------------------------------------VSGQSSHFG-------
----------QH-ES-------RSR-----------------------------------
-----------------------QS-S-----Y---------GQHGSGS-----------
------------------------------------------------------------
-SQSSGYGQ--YG---------------------S-------------------------
----------------------------------R-------------------------
---------------------------ETSGFGQH-----EL------------------
------------------SSGQSSS-----------------------------------
------------------------FGQHGSG------SSQSSG-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------FGQH-----------------------
-------GSGSGQSSGFGQHES-RS-G-QSS--------------------YGQHS-SGS
SQSSG-YGQHG-------------------------------------------------
------------------SRQTSGFGQHGSG-----------------------------
--------------------------SGQS---SGFGQHEFRS--HQS------------
--------------------------------S-Y-------------------------
------------------------------------------------------------
-------G--------------------------QH-GSG--------SS-QSSGY----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------GQQG--------SSSG-QTSGF--GQHRS------
-------SSG------------Q-------------YSGFGQHGS-GSG-QSR-GF---G
QH-ES-RS-GQ-SSY-G-QHSS-GS-SQ-SS----------GYG-QHGSRQ--TSGFGQ-
------------------------------------------------------------
------------------------------------------------------------
----------------HESGS------------------------GQYSGFGQH------
ESRSHQ------------------SSYGQ---HGSGS------------------S----
----------QSSGYGQHGSS---------SGQTFG------------------------
------------------------------------------------------------
-----FGQ------HRS----GSGQ----S------------------------------
----------------------------SAFG----------------QDRS-------G
S-------GQS-SG----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--FGQ-H-----------ES-GSGQSSGFGQHES-RSSQSS-YGQHGS-GSSQ-SS----
---GCGQHGSS-SG--Q--TTGF-GQ-------------HGS---SS---GQYSGFG-QH
GSGSG---QSSGFGQHGTGSEHSSGFGQHE-SRSR--------QS--SYGQHGSG--SSQ
SSGYGQHGSNSGQTSG------------FGQHRSGSGQSSGFGQYGSGSGQSSGFGQHGS
GTGKSSGFA--------------QHEYRSGQ-SSYGQHSTGSSQSSGCGQHESGSGP---
-------------------TTGFGQHVSGSYKF---------SSSGQHISDSGQSTGF--
------------------------------------------------------------
------GFGQYGSGSGQSTGLGPGESQQVESASTVH------------GRQETTHGQT--
--INTTRH------SQSGQG---------------QSTQTGSRVTRRRR-SSQSENSDSE
VHSRVSH----RHSEHIHTQAGSHYPKSGST-----------------------------
------------------VHRRQGTTHGQR-----------------------GDTTRHG
HSGHGQSTQTGSRTSGRQRFSHSDATDSEVHSGVSHR---------PHSQEQTHSQAGSQ
HGESESTV----------------------------------------------------
-----------------------HERHETTYGQTGD------------------------
------------------------------------------------------------
----TTRHS---------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------HSGH
EQTTQTGSRTTGRQRTSHSESTDSEVHSGGSHRPRSQEHTYGQAGSQNGEPEFTVHERHG
TTHGQT-------------------------------------------------GDTTG
HSHSG---------------HGQSTQRGSRTTGRQRS-----------------------
------------------------------------------------------------
-SHSESSDSEVHSGVSHTHTG-----H-TYGQAGSQHGQSESIVHERHGTTHGQTGDTTR
HAHY----HHGLT-------------------------T-QTGSRTTGRRG-SGHSEYSD
SEGY-----------------------------SGVSHTHSGHTHGQAGSQH------GE
SES------IVHGGHGT-IHGQTGDTTRHAHSGHGQSTQT--GSRTTG-RKASGHSEYSD
SEGHSGFSQRP-------------------------------------------------
------------------------HSREHTHSQAGSQHGESESIVDERHRTTHGQTGDTS
GHSQSGHGQSTQSGSST-----------------------------------------TG
RRRSGHSESSDSEVHSGGSHTHSG---HT----------------HSQAR---------S
QHGESESTVHERHQTTHGQTGDTTEHGHPSHGQT-------TQTGS--------------
-------------------------RTTGRRGSGHSEYSDSEGH--S-------------
------------------------------------------------------------
------------------------------------------------------GVSH--
---------------THSGH----------------------------------------
--THGQAGSQRGESG---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------SSVHERYGTTHGQTGDTTRH-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------AHSGH---------------GQSTQRGSRTAGRRGSGHSESSDSEVHSGVSHTH
S-----------------------------------------------------------
-------------------------------------------------GHTHGQARSQH
GESGSAIHGRQGTIHGQTGDTTRHGQSGHGQSTQTG-----SRTTG--------------
------------------------------------------------------------
--------------RQRSSHSESSDSKVHSE-ASPTHSGHIHSQAGS-------------
----------------------RHGESGSSGRGTQGTTHGQTGDTTRHAHYGHGQSTQRG
---S-------RTTGRRGSGHS------------E-------------------------
-----------------------------------------SSDSEVHSWG---------
-----------------SHT--HSGHIHGQAGSQQRQPG----STVHGRLETTHGQTGDT
IRYGHSGYGQSTQTGSRSS--R---TSHFQSH--SSERQRHGSSQVWK---HGSYGPAE-
-------------------------------YDYGHTGYGPSAG-SRK-SISNSHLSWSI
DSTANK--QLSRH-----------------------------------------------
------------------------------------------------------------
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-------------

----------------MPQLLRNINGIIEAFRRYARMEGD-CAVLERGELKRLLEKEFAD
VIVKPHD-----------PATVDEVLRLLDEDDTGTVEFK-----------E-FLV-L--
-V---------------F-K-V-A-Q-A-C-FET----LSEGP-EGVCG---S-----QE
SGRG-----AP-A----ATQEPGA-GQRSSTAV--GRPGNRQGPAG--------------
-------SS-------------------------------------------------DS
QSEQA-----------SRGPGG---------------PGPQTQG----------------
------------------------QDISCAQVSHQDR------------------QSESQ
RQEGV-SQSTQARGHVEQAQRMREDKSSQTRE------R--------------G-----T
ERQL-----QASNQDRAHQTSETI-TGTI-------------------------------
--------------------------------------------TQTRT-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------SATQA--------------VEQDRSH--------------QT
GSASTHTSTQPRESTRGTET----------------------------HSQDGNQTSQVV
TGGHVQAETRPQT-----------------------------------------------
------------------------------------------------------------
---QIHTHTTEQDRSH----------------QTGSTSTQPQESTRESTRGTETHSQDRY
Q---------------TRQVVT---GG--HI----------QTQGGAPQA-M--------
-----------------------------------------E------------------
------------------------------------------------------------
----------------------QDRGQITRHTGAGE------------------------
---------------------------------------------------QGQPQ----
RQSGSSQRQTQVSNCEA-GE----------------------------------------
---------TVLG-------------------------GQAQTGASTVTGRQDRSSTHPP
SSA----------TGGQG-----------------------ERDPT--------------
-------VVHQEWVDDHTRET---VIRRQDQGS----LHA--------------------
------------------SVPSAQGREAAP------------PD-GKRGLT-ARG-----
----------L--------------------------YSYFKSSKP--------------
------------------------------------------------------------
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-------------

----------------MPQLLRNINEIIEAFGRYARTEGS-CPVLTRGELKRLLEHEFAD
VIVKPHD-----------PATVDEVLHLLDEDDTGTVEFN-----------E-FLV-L--
-V---------------F-K-I-T-Q-A-C-FKT----MSKSP-EETCG---S-----QE
SGSL-----PT-G----ASQELRK-EQSKRAEV--RQIREGQICER--------------
-------SQ-------------------------------------------------CV
QRTLA-----------SRGQAG---------------VGAQNHA----------------
------------------------QGLG------QDR------------------QSESQ
RQEKE-SQQTQARRHVQQTQRVGGDKSHQIRQ------R--------------E-----S
ERQS-----QTREQDRAQKTSELV-TRTG-------------------------------
--------------------------------------------TQTQT--DENQTVEQD
RSHHIESPDTRSQESTHGQTRGT----------------E--------------------
-----VQGQDRSQTSQ-----ILT-EHVQTP-------------GGI-----TRAMEPDR
SHQIGSPDTQLQ---ES-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------SHDQSRGSEV----------------------------QGEDRSQVSQIL
TGECVQTPG---------------------------------------------------
------------------------------------------------------------
----GATQAMELDRSH----------------QIGSPDTQLQESSHGQTRGSKVQGQNRC
Q---------------TSEVVT---GE--QI----------QTQAASETQTH--------
-TQAM------------------------------------E------------------
------------------------------------------------------------
----------------------QYRSHNASDIGDRN------------------------
---------------------------------------------------EGQTQ----
RQSGRGHRWTQVSHYEA-GE----------------------------------------
---------KKLG-------------------------GQAQAGTNTLTGRQDWRSTHPR
CSV----------TGGQR-----------------------EREPT--------------
-------VVTQEWVDDHTREM---EIPRQGHGS----LHT--------------------
------------------GMPSAQGQEAAQ------------PE-GKRGLT-ARG-----
----------L--------------------------YSYFKSNKP--------------
------------------------------------------------------------
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-------------

----------------MSKLLRGIFCVIETFHKYASKDGDNKARLTLRELRQLLEGEIGN
FLQPQV------------FHAVERKLDLLNIDRDGTISFE-----------E-FLL-A--
-I---------------F-S-L-L-N-L-F-YFD----I-S-----LLS---S-EPRL--
-MSKS-EK--MDD------VDLLATT---RS---------SQKVVG---VGPT-------
-----------QERL----------------VFAS----------------------EIT
SSAQPSHEEG----------------EMDEQNRTS-PLEDIKTHNLPGEVSEPNDP----
---ENQHP-------------------------------------------------EED
---------SQEVAQDVPATESDGVQ-FKRNT---PAEASKQNDSSTQ--------VIPK
EGG-KV----VRRQSDT------KVSDHM-------------------------------
-----------------------------------------------------AQRPSE-
-----------------DE------------------EHA-----------STTQDPLP-
------P------------------KEDK-A-------------TLEHA---DLP-----
IEAASGKPSQTQ---KFFELMDD--ARI----SETGEPGKDAG------------RTPPE
------------TTN--LKDPKADRR---------------------TSEIQGLPEQE--
------------------------------------------------------------
------------------------------------------------------------
------------------RKHETRNQSAQSGSRDD----SETSSRG--------K-----
------WEEEQ-KE--------------------HER---------------------KT
EPPAP-------------EAQTQNEKC--QEFSRSW-------RENGAKKGSGT------
-----------------------------------------QGLSSEKGNEN-----LPE
I--------------K-------EE----Y-VSEEEARHSEKDIADAFLSNKESPTAEET
RGTRE----------RSQE-----------------------------------------
--------------------------------------------LAPLEK-QSQGKSHRA
TKTHDK--VARKEDHSE-----------------------------------GEDPELPV
TQNDEGPCESPSGLAPEIGNSSSDSS---------------E------------------
--------LQVPGDLQ------------------SQVDTHGDAK---------QGSDDNN
SDP---------------------------------------------------------
------------------------------------------------------------
---------------------------------------------RKQRASGDSSRVQEA
V------ELLVQ------------------------------------------------
--EGRGLPEEQGQSAREK----------------------QDGIGAAVEPSEEGEVQ---
---ESTAGG--ENRKSPEAESSGAQ-----------------------------------
------------------------------------------------------------
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----------------MSTLLENIFAIINLFKQYSKKDKN-TDTLSKKELKELLEKEFRL
ILKNPDD-----------PDMVEVFMDHLDIDHNKKIDFT-----------E-FLL-M--
-V---------------F-K-L-A-Q-A-Y-YES----TRK---Q-NLP---T-------
SGHKHRKHSHH----------DKHEDNKEEEN--------KE-------KRKR-----PL
SLERRNNR-----KGNTG--RSKSPRETGGKRHES-----------------------G-
-SEKKERKG------------------------YSPT-HREEEYG-QNHHKSSK------
--------------------------------------------KEKNKAEI-TRLEHNG
K--R-----------------------ISER-------------PEEK----EE-----K
EDGQYD-------------------YENTG------------------------------
------------------------------------------RMTEKWTESGHAAIYYAI
QDE--AD-----D----I---------TDNILEENRRYET-----SR-------------
------------------------------------------------------------
------------------------------------------------------------
-----------SSHD-ESSHR-VNRSR--------------------HANTSQVPLVES-
RRRTGQG--SSVSK----------------------------------------------
------------------------------------------------------------
-----------------------DSEIE-GHSEDSERR-SGLASRNH-------HE----
--SVQ--------E--QSRDGSRHH------G-SHQE-----------------------
---------------------------------------D--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----RAGHRNSA------DSSRQSG-----------SCHTETSSRGQAVA---------
SQE---------------------------------------------------------
---------------------------------------------QERSSPGE-------
----------RH-GS-------RHQ-----------------------------------
-----------------QSADSSRH-S-----G---------TGRGQAS-----------
------------------------------------------------------------
-SAVSDRGH--QG---------------------PSGSQVSDSEGHSEDSDTQSVSG---
-------------------------------QRQA-------------------------
---------------------------GPHPHSHQ-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------ESVRGRP-----------------------
-------GERSGRSGSFLYQVSAHE---QS---------------------ESTHGRTGH
------------------------------------------------------------
-------------------------------------------------STGGRQGSRNG
QARD-------------------------------------SS--RHSA-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------SHEGQDTIHGHPGSSRGGRHGS-------
HHEQS----VDSSGHSGSHHSHTTSQGR-SD----------A-------------SRGQS
-GSRSA--SRQTRHE-----EQ---------------------SG--------DG-----
----------SRHSGSRH------HEVSTQ---------------------------ADS
SRHSQSGQGQSVGFRTST---------------------------RRGSTVSQD------
SDS---------------------------------------------------------
------------------------------EGNSE-D-----------------------
-SERQS-----------ESA-----------S----------------------------
-----RNH------HGS----VREQSTDGS------------------------------
----------------------------RYPGS---------------HH----------
---------EDTAHHR--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------HSADS-S
RQSGTRH-----------AE-------------------TSSRGQAASSHEQTRSSP---
----GERHGSR----------------------------HQ----QSADSSRHSGTG---
-------------------RGQASSAVS-------------------DRGHQGPS--GSQ
VS-------DSEGHSEDSDTQSVSGQRQAGPHPHSHQE----------------------
------SAR-----GRS-GERSGR-------------SGS--------------------
----------------------F-------------------------------------
------------------------------------------------------------
--------------LYQVSTHERSESTHGRTGHST------------GGRQGSRNGQA--
--RDTSRH--SASH--EGQDT--------------IHGHPGSSRGG-RHGSHHEQSV---
-------------------------------------------------DSSGHSGSHHS
HTTSQGRSDASRGQSGSRSASRQTRHEEQSGDGYRHSGSHHHEASNRAD------SSRHS
QSGQG--QSVGFRTSTRWGSSVSQDSDNEGYSEDSER---------QSES----------
------ASRNHHGSVWEQSRHGSRHPESHHEDRAGYGHS------------ANSSRQSGT
RHA---------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------ETSSHGQA
ASTHEQARSSP--GERHGSRHQQSTDSSRH----SGT---GRGQAS-SAVSDRGHQG-PS
GSQVSDSEG HSEDSDTQSV------SGHGQARPHPHSHQESARGRSGERSGRSGSFLYQA
STHEQSESTHGRTGHSTGGRQGSRNGQARESSRHSASLEGQDA-----------------
-IHRHPGSSRGGRQGSHHEQSVDSSGHSGSHHSHT---TSQGRSDSSRGQSGSRSASRQT
RH EEQS-------------------------------------------------GDGSW
HSGSRHHEASNRADTSGHSESRQGQSGGFTTSRRRGSSVSQDSDSER HSEDSERQSESAS
RN----------------------------------------------------------
------------------HHG-------S-VWEQSRHGSRHPESHHEDRAGYGHSADSSR
HSGT--------------------------------------------------------
------------------------------------RHTET-SSRGQAAS----------
--S HEQARSSPGERHGS-RHQQSADSSRHSRTGRGQASSAV----SDRGHQGPSGSQVSD
SEG HSEDSDTQSVSGHGQPGPHPHSHQESVRGRSGERSGHSG------------------
----------------------SFLYQVSTHEQSESTHGRTGHSTGGRQASRNEQARDSS
RHSASHEGQDTIHRHPES--------------------------------------SRGG
RQGSHHEQSVDSSGHSGSHHSHTT-----------------------------SQGRSDA
SRGQSGSRSASRQTRH EEQSGDGSRHSGSRHHEAS-------------------------
TQADSSRHSQS--GQGQ----SVGFRTSTRRGSSLTQDSDSEG H--SEDSERQSESA---
---S--RNHHGSVWEQSRHGSRHPESHDEDRASHRHS-----------------------
---ADSYRQSGKRHAETAFHGQAASS HEQ-TRSSPGERHGSRHQQSADSSRHS-GTGRGQ
ASSAVSDRGHQGPSGSQVSDSEG HSEDSDT-----------------------------Q
------SVSGHGQAGPHLHSHQESARGQSGER----------------------------
------------------------------------------------------------
--------------------------------------SGRSGSF------LYQVSTHEQ
SEFTHGRTGPRSGGRQRSRREQAQDSSRHSAS---QEGQ----HTIHKHPGSSRGGRQGS
HHEQSVDSSGHSGSHHSHTTS---------------------------------------
----------------------------------QGRSDASRGQSGSRSESRQTRH EEQS
GDRYRHAGSPHHQASTRADSSSNSQSGQGQSAGSRTSTHQGSNVSQDSDSEG HSEDSERW
SGSASRNHHG-----S-AQEQSRDGSR---------------------------------
-----------------------------------------HLGSHHEDSAS--------
--------------HAHSTDSSRQSGTRYTENSSHGQAASSR EQTRSSPG----ER---H
GSRHQ-QSAD-------SSRHSGTGRGQ--------------------------------
-----ASSAVSDRGHQGPSGSQVSDSEGHSE-ASDTQLVSGHGQAGPHPHSHQESARGRS
GERSGRSGSFLYQVSTNEQSESTHGRTGHSTGGKQGSRNGQARDSSRHSVSHEGQDTIHG
H-------PGSSRGGRQGSHHEQSVDS---------------------------------
---------------------------------------------SGHSGSHH-------
----------------------SHTTSQGRSDASHGQSG----SRSASRQTRHEEQSGDG
YRHSGSHHHEASNRADSS---RHSQSGQGQ-----------------------SVGI---
-------RTSTHQGSSVSQDSDSE------------------------------------
------------------------------------------------G-YSEDSERQSE
--------SASRNHHGSVWEQSRHGSRHP-------ESHHEDRASHG--------HSADS
------------------------------------------------------------
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----YRQSGTRHAETSSRGQAASSHEQT---------------RSSPGERHGSRHQQSAD
SSRHSETGRGQASS-AVSDRGHQGPSGSQVS----DSEG HSED----SDTQSVSGQRQAG
PHPHSHQE----SARGRSGERSGRSGSFLYQVSTHERSESTHGRTGHSTGGRQGSRNGQA
----------RDTSRHSASHEGQDTIHGHPGSSRGGRQG---------------------
---SHHEQSVDSSGHSGSHHRHTT-SQGRSDASRGQSGSRSASRQT---R-H EEQ-----
--------SGDGYRH-----------------------------SGSHHHEA--------
-------SNRADSSRHSQSGQGQSGGFRTSTHRGS-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------SV
SQDSDSE GY-SEDSERQSEFASRNHHGSVREQSTDGSRHPGSHHEDRASHGHSADSS-RQ
SGTRHTETSSHGQAASSH----------------------EQARSSPGERHGFRHQ-Q--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------SADSSRHSGTGRGQ
ASSAVSDHGHEGPRGSQVSDSEG HSEDSDTQSVSGHGQAGPHPQSHQESARDWSGERSGR
SGSFLYQVSTHERSESTHGRTGPSTGGRQVSRNEQARDSSRHPVSHDGQDTIHGHTGSSR
GGRQGFHHEQSVDSSGHSGSHHSHTTSQGRSDASHGQSGSRSESRQTRH EEHSGDGYRHS
GSGHHEASNWADSSRHS----QSGQGQSGGFRTSTRWGSSVSQDSASEGHSEDSERQSES
ASRNPHASVREQ-SRDVSRHPRSYYHDT----ANHVQSS----SVHSDTSTSKEHGHFGS
LSQDSEYRSGMQS-RGSP----HSSSSYNYHSEGTERERGQSGLVWRHGSYGSADYDYGE
SRFRPSQHGSVSYNSNPVVFKERSDIRKASAFGEDHPRYYATNINRQPGLYGHSSDISKQ
LGFSQSQRYYYYK

----------------MSPLLRSIFNITEMFNQYASHDCD-GAALSKKDLKNLLEREFGD
VLRRPHD-----------PETVDLILELLDRDCNGLVDFN-----------E-F-L-L-F
-V---------------F-K-V-A-Q-A-C-Y--Y-A-L-S-Q-A-AG--L-D------E
K--GA-N-C-E-G-K-D-NP-L--QD-PRQKED-Q-R-----------------------
-------------------------------RF-------------------------EP
QDTQFEERRQ----------KRQE----LER--EL-AEEEQ-----------QRLQ----
---------------------------------------------------------RRE
Q------------------------------------ERRLEEEEHLQRRKGREPETLPD
QEQRRE----RQAQRELQEEEHLQRRERQEQ--GERA---LEEEGEQLQRQRRQ------
-------------ERHL----------E-QELRREQERRMQEQEQELR-REEQELRREQE
-----------------------------LRREQE-LRRK-------------E--PRL-
-----EQELRR-EQELR--------RKEQRL-----------------------------
----------EQ---ELRREQELRREQE-QT-REQ----LR-----RK---E-------P
RL--------------EQEL-----RRRQEERREQELRREQEPR---RDEPQQ-------
--RREQLR------RKEQR----------L-EQELGREQELRHEQELRRE-EQELR----
R-EQELRREQ---ELRRNEQRL--------EQELRREQEE------RREQELRREQ--EL
RREEPR----------------------------------------------------LE
QELGR--------E--QELRH-EQE------L-RREEQELGREQE---------------
-----------LRREQELRR----------------------------------------
--------------------------------------------------------NEQR
LEQELRREQELRRKEPRLEQELRGEQGRREQLRREEQRLEQELRREQEERREQELRREQE
LRREE--------------------------------------------PRLEQELRREQ
ELRRK-----------------EPRLEQELRREQ-ERREQLRREEQRLEQEL--------
----------RR------EQEERREQ----L-R-REE-QRLE-QQQRR----EQQLA---
---------------E--EV---EQE---------------EA-----RERGKCRTPRWQ
WQLESE-------------------------------AEARQSK---VYSR---------
PRR-QKEE-----KRQRQELEQQL------RA-------Q------------E-------
-------------EDAQGQRGAR---P----------L------GEERERGLQ-------
----------REEQVRRLEAEEEQRRDSKWQWQAEE-----ESERRRQRLS---------
-----A-RPALQEQRERQLRAEEPQ-E-----R-----ELFREEEQQRR--------RLE
RGQEQQVREEEKQLR----------LENFQEDQGRKLRQEEQRRDQKWRWQ--PDEES--
-Q---------RHRHIVYA-------KP------AEREQLREEEQ----V-----QREER
---------------------------EKRRRQEEPLL-QEREEQL--------------
------------------------------------------------------------
--------------RRQERDRKFREEEQLLQ-------------------------EREE
QLR---------RREREQQLRQERDRKFREEEQLLQEREEQLR-----------------
-QERDRKFREEEQLLQERE-EQLRRR----------------------------------
------------------------------------------------------EREQ--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------QLRQERDRKFR----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------EEEQ----LLQERE-EQLRRQEHDRKFREEEQLLQE-R-EEQL
RRQEHDRKFREEEQLLQER------------------------EEQLRRQERDRKFREEE
QLLQER-------------------------EEQLRRREREQQLCQERDRKFREEEPLLQ
ERE-------------------EQLRRQERDRKFREEEQLLQERE-----E-QL------
----------RRQERDRKFREEEQLLQEREEQLRRRE-----------------------
----------REQQLRQERDRKFREEEPLLQERE-EQLRRQERDRKFREEEQLL--QERE
EQLRRQERDRKFREEEQLLQERKSSCAGGNVSSSCARS---VTGS-----SVR-R-NRSC
RK--------GKSSCAGGNV--------------SSSCARSVTG----SSARRNSSCRKG
------KSSCAGGNV-SSSCARSVT----GSSVRRNSSCRKGKSSCAASRERIRGAVAKS
GKKETKAEGRLWSPA-------------S-------------------------------
-----------------------VRLLVSRCAPALSMSTSKSRDL--STALKRCYQYPDT
CQSFQQKIMRKHWIP-----------------NNSRCFWLWENSLMFQNLFFPK------
--------------L---------------------------------------------
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----------------MPQLLRNINGIIEAFRRYARTEGN-CTALTRGELKRLLEQEFAD
VIVKPHD-----------PETVDEVLHLLDEDHTGTVEFK-----------E-FLV-L--
-V---------------F-K-V-A-Q-A-C-FKT----LSESP-EGACG---S-----QE
SGSL-----HS-G----ASQELGE-GQRSGTEV--GRAGKGQHYEG--------------
-------SS-------------------------------------------------HR
QSQQG-----------SRGQNR---------------PGAQTQG----------------
------------------------QATGSPWISSYDR------------------QAESQ
SQERT-SLQIQLSGQTEQTQKAGEGKRNQTTE------M--------------S-----P
ERQP-----QTREQDRAHQTDETV-IGSG-------------------------------
--------------------------------------------TQTQA--GATQTVEQD
SSHQTGRTSTQTQEVPNDQNRGT----------------E--------------------
-----IHSQGRSQTSQ-----AVTGGHAQIQ-------------AG--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------THT-----------------------------------------------
------------------------------------------------------------
---QTPTQTVEQDSSH----------------QRGSTSTQTQKSTNGQNRGTEIHGQGSS
Q---------------TSQAVT---GG--HT----------QTQAGSHTQTV--------
-----------------------------------------K------------------
------------------------------------------------------------
----------------------QDRSQTVSHGGARE------------------------
---------------------------------------------------QGQTQ----
MQPGSGQKWTQVSNPEA-GE----------------------------------------
---------TVTG-------------------------GQAQTGASTESGRQEWSSTHPR
RCV----------TEGQG-----------------------DRQPT--------------
-------VVGEEWVDDHSRET---GILRLDQGN----LHT--------------------
------------------SVSSAQGQDAAQ------------PE-EKRGIT-ARE-----
----------L--------------------------YSYLRSNKP--------------
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----------------MTDLLRSVVTVIDVFYKYTKQDGE-CGTLSKDELKELLEKEFHP
ILKNPDD-----------PDTVDVIMHMLDRDHDRRLDFT-----------E-FLL-M--
-I---------------F-K-L-T-M-A-C-NKV----LSK---E-YCK---A-------
SGSKKHRRGHR----------HQEEESETEEN--------EE-------DTPG-----YK
SGYRHSSWSEG-EEHGYS---SGHSRGTVKRRHGS-----------------------N-
-SRRLGRQG------------------------NLSSSGNKEGSQ-KRYHRSSS------
---------------------------GHSWS--------S--GKERHGFSS-GELRERI
N--------------------------KSHI-------------SPSR----ES-----G
EEYESG-------------------SG---------------------------------
--------------------------------------------SKSWERKGHGGLSCGL
ETS--GH-----E-SNST---------QSRIR-GQKLGSS-----CSGSGDSGRRSHACG
YS---------------------------------------------------------N
SSGCGRS---QN---ASSSCQSHRFGGQGNQFSYN-QSGCQSGINGGQGHGCVSGGQPSG
CGQ-----PESNSCS-ESYSQTGYGA----------------------RENGQ--PQNC-
GGQWRTG--SSQSSCCGQY-----------------------------------------
-----------------------------------------------G-------S----
-GGSQSCSNGQH-----------EYGSC-GHFSNSSS----SNEFS--------------
---KC--------G--QYGSGSGQS------T-SFEQ-----------------------
---------------------------------------RGTGL----S-----------
---QSSG---------FEQHVS---G-----------------SGQTCGQH---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------ESTSSQS-
------------LGYDQ-HGSSSGK-----------------------------------
-----TSGFGQHGSGSGQSSGFGQCE-----------LGSGQSSGFGQHGS---------
V-----------------------------------------------------------
-------------SGQSSGFGQH---G----------S------VSGQSSGFG-------
----------QH-ES-------RSR-----------------------------------
-----------------------QS-S-----Y---------GQHSSG------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------S
SQSSG-YGQHG-------------------------------------------------
------------------SRQTSGFGQHGPGS----SQS----------T---------G
FGQYG-SGS-GQ--SSGFG-QHA-SGSGQS---SGFGQHESRS--GHS------------
--------------------------------S-Y-------------------------
------------------------------------------------------------
-------G--------------------------QH-GFG--------SS-QSSGC----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------GQHG--------LSSG-QTSGF--GQHEL------
-------SSG------------QSSSFGQHGSGSGQSSGFGQHGS-GSG-QSS-GF---G
QH-ES-RS-RQ-SSY-G-QHSS-GS-SQ-SS----------GYG-QHASRQ--TSGFG-H
-GSGSSQ---------STGFGRYGSGSGQSAGFGQRVSGSGQSSG--------FG-----
----------QHESRSGHSGYGQHGFGSSQSSGCGQHGSSSGQT-SGFGQHELSSG----
---------QSSSFGQHGSGS------------------------GQFSGFGQH------
ESRSSQ------------------SSYGQ---HGSGS------------------I----
----------QSSGYGQHRSS---------SGQTTG------------------------
------------------------------------------------------------
-----FGQ------HRS----SSGQ----S------------------------------
----------------------------SGFG----------------QHGS-------S
S-------GQS-SGLG-HHG-T-GS-G-Q-SS-C-F--------G-PH-D-S--------
--------------------R---S----------------------------------H
--Q-------------S-S-Y-------G-------------------------------
--PT----------W-I-P-G-F-KX-X-X-XX-X-H-E-L----------S-SGQS--S
S-FGQ-H-----------GS-GSGQFSGFGQHES-RSSQSS-YGQHGS-GSIQ-SS----
---GYGQHRSS-SG--Q--TTGF-GQ-------------HRS---SS---GQSSGFG-QH
GSSSG---QSSGFGQHGTGSGQSSGFGQHE-SRSH--------QS--SYGQHGSG--SSQ
SSGYAQHGSNSGQTSG------------FGQHRSGSGQSSGFGQYGLGSDQSSGFGQHGS
GTGKSSGFA--------------QHEYRSGQ-TSYGQHGTGSSQSSGCGQHESGSGP---
-------------------TTGFGQHVSGSDNF---------CSSGQHISDSGQSTG---
------------------------------------------------------------
-------FGQYGSGSGKSTGLGEGESQQVESGSTVH------------GRQETTHGQI--
--INTTRH------SQSGQG---------------QSTQTGSRVTRRRR-SSQSENSDSE
VHSRVSH----RHSEHIHTQAGSHYPKSGST-----------------------------
------------------VRRRQGTTHGQR-----------------------GDTTRHG
HSGHGQSTQTGSRTSGRKIFSHSDATDSEVYSGVSHR---------PHSQEQTHSQAGSQ
HGEPESTV----------------------------------------------------
-----------------------HERHETTYGQTGA------------------------
------------------------------------------------------------
----ATGHGHSGHGQSTQRGSR--TTGRRGSGHSES-SDSEVHSGGSHRPQSQEQIHGQA
GSQHGESGS--TVHGRHRTTHGQTGDTTRH----AHY---HHGLTTQTGSRTTGRRG-SG
HSEYSDSEGYS-----------------------------------------EVSHTHSG
HTHGQAGSQHAESESTVDERHGTIHGQTGDTTRHA---------------------HSSH
GQSTQTGSRTTGRRASGHSEYSDSEGHSGFSQRPHSQGHTHGQAGSQHGESESIVDERHR
TTHGQT-------------------------------------------------GDTSG
HSQSG---------------HGQATQSGSSTTGRRRS-----------------------
------------------------------------------------------------
-GHSESSDSEVHSGGSHTHSG-----H-THGQAGSQHGESKSTVHERHQTTHGQTGDTTE
HGHP----SHGQT-------------------------T-QTGSRTTGRRA-SGHSEYSD
SEGH-----------------------------SGGSHTHSGHTHGQAGSQH------RE
SGS------SVHEKHGT-IHGQTGDTTRHAHSGHGQSTQT--GSRTTG-RRASGHSEYSD
SEGHSGFSQRP-------------------------------------------------
------------------------HSRGHTNGQAGSQHGESESIVDERHRTTHGQTGDTS
GHSQSGHGQATQSGSST-----------------------------------------TG
RRRSGHSESSDSEVHSGGSHTHSG---HT----------------HGQAG---------S
QHGESKSTVHERHQTTHGQTGDTTEHGHPSHGQT-------TQTGS--------------
-------------------------RTTGRRASGHSEYSDSEGH--SGDSHTHSGH----
-------------------------------THG-QAGSHYPES----GSSVHERHGTTH
GQTADTTRHGHSGHGQSTQRG------SRTTGRRGSG-----HSESSDSEGHS-GVSH--
---------------THSGH----------------------------------------
--THGQAGSQHGESG---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------SSVRERHGTTHGQTGDTTSH-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------AHSGH---------------GQSTKRGSRTAGRRGSGHSESSDSEVHSGVSRTH
S-----------------------------------------------------------
-------------------------------------------------GHTHGQARSQH
GESGSAIHRRQGTIHGQTGDTTRHGQSGHGQSTQKG-----SRTTG--------------
------------------------------------------------------------
--------------RQRSSQSESSDSEVHSE-ASPTHSGHTHSQAGS-------------
----------------------RHGESGSSGHGRQGTTHGQTGDTTRHAHYGHGQSTQRG
---S-------RTTGRRGSGHS------------E-------------------------
-----------------------------------------SSDSEVHSWG---------
-----------------SHT--HSGHIHGQAGSQQRQPG----STVHGRLETTHGQGGDT
TRHDHSDYGQSTQTGSRSS--R---TSHFQSH--SSERQRHGSSQVWK---HGSYGPAE-
-------------------------------YDYGHTGYGPSGG-SRK-SISNSHLSWSI
DSTANK--QLSRH-----------------------------------------------
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-------------

----------------MPRLLRGVFCVVEIFHKYAIEDGGNQATLTRTELRQLLEGEIGD
FLQPHV------------FHAVERKLNLLNFDRDGTISFE-----------E-FVL-A--
-I---------------F-S-L-L-N-P-S-YFD----I-S-----LLN---S-EPRL--
-MSKS-EK--IDA------VDLGAIG---GN---------IQQVVG---VGPT-------
-----------QERL----------------IFPS----------------------EMA
SSGQPSNEEG----------------EVGDEPMVS-PCEDIKTHSLPRNVSEPNDP----
---ENQQP-------------------------------------------------KED
---------AQEVAQNVPATEYDGVQ-FKRNT---VVEVPKQSTSPTQ--------EIPR
ERS-KP----SRRLSDT------KISDHM-------------------------------
-----------------------------------------------------IQRPTE-
-----------------DE------------------EHT-----------STTQDPFL-
------Q------------------KRDKAT-------------GSENT---DLS-----
VVAATRKSSQTQ---EIFEPMDD--TKL----SEAQETGKDAG------------RIPPE
-------------TN--LEEPKADAK---------------------VAESHGLPAQE--
------------------------------------------------------------
------------------------------------------------------------
------------------REHNTRDQSVQSRSRNV----SETSSRG--------E-----
------QEGEW-KE--------------------HER---------------------IT
LSPTA-------------DAETQDEKC--QEFPGSW-------RENDAKKDSAA------
-----------------------------------------KDPSSEEGNQN-----LPE
I--------------K-------ED----S-VSGKEARHSEEDTVYAFEINKNSPAAEET
LETRE----------RSQE-----------------------------------------
--------------------------------------------LAPLEK-QSQRKKHRA
TRIQDK--PVRKEDHNE-----------------------------------GEDSELSL
TQSDEGFCEIPNSLAPEVGKSSSEIA---------------E------------------
--------PHVPEDSQ------------------SQIDHHGDAK---------QESHTNN
PDP---------------------------------------------------------
------------------------------------------------------------
---------------------------------------------QKQGAPGESSREQEA
V------VLSIQ------------------------------------------------
--EDGQLPEGQEQSARDGLHDG--------LSSR-----TKGGPGAAVEPSEGEEVQ---
---EATAGR--ENRKALEAESLEAQ-----------------------------------
------------------------------------------------------------
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-------------

----------------MSQLLRSIVTVIDVFYNYCGQDEE-CDTMCKKELKELLYKEMGP
LLKNPNN-----------PDTVDIFMQILDRDHDRRVDFT-----------E-YLL-M--
-V---------------F-K-L-T-M-A-C-NKS----VGK---E-YCH---A-------
SGSKRKQQGRH----------HQEKQSETEDQ---------E-------ELKG-----HE
SGSSHSSWSSG-EEYGSS--RSGRSQGSKQHGHKY-----------------------S-
-STGWRKKD---------------------------YSGNGEGSG-KNYHRSSS------
---------------------------SYSRS--------S--SQEKHGFKDNEQWGRRR
N--------------------------SSI------------------------------
------------------------------------------------------------
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-------------

----------------MTELLNSILTVIKVFQRYAKENGD-STSLCKEELKQLLLAEFGD
ILRRPND-----------PETVETILSLLDRNRNEHVDFH-----------E-YLL-M--
-V---------------F-Q-L-A-Q-A-C-YHK----LDN---E-SNG---D-------
RTSQ-QERKQE-G-----TQGHTFPRN-TGR---QH----RRRHEGERQ-----------
-DSCHS-QSEKQSQDTHL--DQ-SEGQD--------------------------------
------------------------------------------------RDSHYGQTQRPD
RDSHYGQTEGQ------------GQDSSSGQRLSN-------------KSGS--GNPERQ
G--YV-------F-------------ALNKYE------EQ------LQ-----------D
SHYGQS-----------------DRLGQQS------------SYGQ-SGRLR--------
--------EDPQYSQTN----------Q-----QESGSYNEQSGRLGQ-KSGCGQRNRQE
LDSHCGQTDRQGLSTHYSQTRPD-------------------------------------
-----------------RQGQSYHYDQTDRQGQ---------------------------
---------------SSQSGQTDRQG-L--S------S-----------HYDQMDRQGLS
-------------------S--HYG-------------------------------QT--
---DR----QGLSSHYGQTDSQG--------------------------------LSSHY
GQTEGQGQDSSSGQR---------------------------------------------
-------------------------------------------LS---------------
------------------------------------------NKSGSGN---P---E-RQ
---------------------G-------YVFA---------------------------
-----------------------------------LNKYEEQLQDSHYGQSDRLGQQSS-
------------------------------------------------------------
------------------------------------------------------------
-------------------YGQSGRLREDPQYSQT-------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------NQQESGSYNEQSGRLGQKSGCGQRNRQELDSHCGQ
TDR-QGLSTHYSQT----------------------------------------------
-----------------------------------------RPDRQGQSYHYDQTDRQGQ
SSQS--GQTDRQGLSSHYDQTDRQSLSSHYGQTDRQGQISHYGETDRQGLSI--------
----------RYSQTDRQAVNSQYGQS---ETGETRQNRYFQGSEG-TS-----------
--R-DSHVEQSGRPGRPSQQTQGQEVN-RNQGQRSQTREGQQNSRQRRDRQ--TREDQQ-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------TRQRRDRQT
HEDEQTRQRRDRQTHEDEQTRQ--------------------------------------
--RRDRQAHEDEQTH-Q-------------------------RQDGQTREDQQTGQSQDR
QTHEDE-------QIH--------------------------------------------
------------QRRDRQTHEDEQTRQRR-----------D-------------------
--------------------------------RQTHEDEQTHQRQDRQTREDQQTGQSQD
RQTHEDEQIHQR----------------QDRQTHEDEQTRQRRDRQTHEDEPTRQRRDRQ
TREDQ-------------------------------------------------------
Q-----------------------------------------------------------
-------TRQRRDRQTHEDEQTRQRRDRQTHEDELTHQRRDRQTHEDEQIHQR-------
----RDRQTHEDE---------------------------------QTRQRQDRQTHEDE
LTHQRR----------------------------DRQTHEDEQIHQRRDRQTHEDEQTRQ
RRDRQTHEDEQTHQRQDRQTREDQQTGQSQDRQTHEDEQTRQ------------------
-------------RRDRQTHEDEQTRQRR--------------------------DRQTH
E----------DEQTRQRRDRQTHEDEQTRQRRD--------------------------
---SRQQQDQQTHKDKERYQESQYQQSQGT------------------------------
------------------------------------------------------------
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------------------------------------------------------------
-------------------------------QQGCANREKLHTNED--------------
----------------------GQSPSS-----QGRRSDLAFH------------PTQNA
GRPQRREQGGSHPIKAT-IAPNPLYDYVQEQKGVWH------------------------
------------------------------------------------------------
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-------------

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------RRSGT--GHGQSS---TGSGSRRHRESSVSQASDSEGY--SGDQSRHSVTTQG-
RSGSTSRNQRGSSHGQAGDTSRRSESRHGQADSHRQRESIHGDF----GSRTSHGQGSRH
EQSRDSSRRS--------------------------------------------GTGHGQ
SSTGSGSRRHRESSVSQASDSE GYSGDQ--------------------------------
---SRHSV----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--TTQGRSGSTSRNQRGSSHGQAGDTSRRSESRHGQADSHRQ------------------
------------------------------------------------------------
-------------------------------------RESIHGDFG SRTSHGQGSRHEQS
RDSSRRSGTGH---------------GQSS-TGSGSRRHRESSVSQASDSEGYSGDQSRH
S-----------------------------------------------------------
--------------------------------------------------------VTTQ
GRSGSTSRNQRGSSHGQAGDTSRRSESH----------------SGSRTS----HG---Q
GSRHE-QSRDS-------SRRSGTGHGQ--------------------------------
-----SSTGSGSRRHRESSVSQASDSEGYSG-DQSRHSV-------T-------------
----------------------TQGRSGSTSRNQRGSSHGQAGDTSRRSESRH-------
---------------GQGSRHEQSRDS---------------------------------
---------------------------------------------SRRSGTGHGQS----
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-------------

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---SSSY---GHHGSTW-GQSS-----------GCEQSGSS-----------SGRSSGYG
-------------HQESSSGHSSRQGRHR--------SSSG-SSSSY--GQHGS------
-------HSG------------QPSGHGQHGSESGQSSRHSQHGS-GEGQSSRHGR----
---------------------------------------------H-ESGSGQSSSYGHQ
-GSTSGQ---------SSGHSQHGSRSGQSSACGKPRSGSGSGS--------GSVS-GSG
---------SSSG-SGQSSGRGRHGSGSGRSPSPGHHGSGSGQS-TGLERHGSGSGHSSS
SSQHGSRSGQSSTYPQGG-SGSGQSSGYG-----------------------QH------
GSGS-GQS----------------SGLGR---HHSGS------------------G----
----------ESSGTGEYGSG---------SGQSS-------------------------
--SYGH-----------H------------------------------------------
---------------GS----TWGQS----------------------------------
------------------------------------------------------------
----------S-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---GCEQ-----------SGSSSGRSSGYGH-----------------------------
-------QESG-SG--H-----------------------------------SSRQG-RH
--R-SSSGSSSSYGQHGSHSGQASGHGQHG-SESG--------QSS-RHSQHGSG--EGQ
SSRHGRH--------------------------------------ESGSGQSSSYGHQGS
TSGQSSGHS--------------QHGSRSGQSSACGKPRSGSGSGSGS------------
-------------GSGSGQSSGRGRHGSGSGRS---------PSPGHHGSSWG QSTGLDR
HGSGSGHSSSSSQHGSR------------------SGQSSTYG------------HKGGS
GSGQSSGYGQHGSGSGQSSGLGRHHSGSGESSG-TGEYGSGSGQSSSYGH HGSTWGQS--
--SGCEQSGS--------------------------------------------------
------------------------------------------------------------
----------SSGR--SSGYGHQESGSGH-------------------------------
------------------------SSRQGRHRSSSGSSSSYGQHGSHSGQASGHGQHGSE
SGQSSRNSQHGSGEGQSSRHGR--------------------------------------
----------------------------------------HESGSGQSSSYGHQGSTSGQ
S-----SGHSQHGSR---------------------------------------------
------------SGQSSACGNALHTSGSSSGS----------------------------
--GLSSGCG--RHVSGSG------------------W-------S-------LGQG----
--HCASRSCXX------------------------------------------XXXXRHE
SGSGQS-SSYSHQGSTSG--QSSGHSQHGSRSGQS-SACGKPRSGSGSG-----------
--------------------------S-----------------GSGS--GQSSGRGRHS
SGSGRSPSPG--------------------------------------------------
-----------------------------HHGSGSRQSTGLDRH----------------
------------------------------------------------------------
----------------------------GSGSGHSS-------SSSQHGSRSGQSSTY--
-GHKG---------------------------------------------GSGSGQSSGY
GQHG--------------------------------------SGSGQSSG----------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------LG
R-HHSGSGESSGTGEYGSGSGQ--------------------------------------
----S-----S-------------------------------------------------
SYGHHGST----------------------------------------------------
-----------------------------------WGQSSGCEQSGS-SSGRSSGYGHQ-
----ESSSGHSSRQGRHRSSSGSSSSYGQHGSHSGQASGHGQHGSESGQSSRHSQ-----
--------H-GSGEGQSS----------------RH------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---GRHEFGSGQSS-----------SYGHQGSTSGQS-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------SGHSQH--------------------------------
-------------GSRSGQSSACG-KPRSGSGSGSGSGSGSGSSSGSGQSSGRGRHGSGS
GRSPSPG-----------------------------------------------------
------------------HHGSSSGQSTGLDRH---------------------------
------------------------------------------------------------
----------------------GSGSGHSSSSSQHGSRSGQSSTYGHKGGS---------
---------------------GSGQSSG---YGQH---G--------------SGSGQSS
GLGRHHSGSGESSGTGEYGSGSGQSSS--YGH---------HGSTWGQSS----------
-----------------------GCEQSGS---------SSGRSSGYGHQESSSGHSSRQ
GRHRSSSG-------------------------------------------------SSS
-------------------S----------YGQHGS-HSGQPSG----------------
----------HGQHGSESGQSSR-----------------HSQHGS--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------GEGQS------SRH---GRHESGSGQSSSYGHQGSTSGQ---
-----------------------------------------SSGHSQHGSRSGQSSACGK
PRSGS--------------------GSGSGSGSGQSSGRGR-------------------
--------------------HGSGSGRSPSPGHHGSGSGQSTGLDRHGSGSG--------
-----------------------------H------------------------------
----SSSSSQHGSRSGQSSTYGHKGGSGSGQSSGYGQHGSGSGQSSGLGRH---------
----------------------------------HSGSG---------------------
------------------------------------------------------------
--------ESSGTGEYGSGSGQSSSYGHH-------------------------------
-----------------------------GSTWGQSSGCEQS------------------
--GSSS-------GRS------SGY------GHQESGSGHSSRQGRHRSSSG--------
SSSSYGQHGSHSGQAS-HGQHGSESRQS----SRHSKHGSQSGQCTLF---KQGSDCGL-
---------ENTYAFSHKFCSS--SPLYLYI-----------------------------
----------HEQ--RRSFQT---------------------------------------
------------------------------------------------------------
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-------------

----------------MPQLLRNINGIIEAFRRYARTEGS-CTALTRGELKRLLEQEFAD
VIVKPHD-----------PATVDEVLRLLDEDHTGTVEFK-----------E-FLV-L--
-V---------------F-K-V-A-Q-A-C-FKT----LSESP-EGACS---S-----QE
SGSL-----HS-G----AWQELSE-GQRSGTEV--GRAGKGQHYEG--------------
-------SS-------------------------------------------------HG
QSEQP-----------SRGQSR---------------PGAQTQG----------------
------------------------QATGSAWVSSYDR------------------QAESQ
SQERT-SPQIQRSGHTEQTQRAGEGKRHQTTE------M--------------R-----P
ERQP-----QTREQDRAHQTSETV-TGSG-------------------------------
--------------------------------------------TQTQA--GATQTVEQD
SSHQTGRTSTQTQEATNDQNRGT----------------E--------------------
-----IHGQGRSQTSQ-----AMTGGHAQAQ-------------A---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------GTHT-----------------------------------------------
------------------------------------------------------------
---QTPTQTVEQDSSH----------------HTESTSTQTQGSTNDQNRGTEIHGQGRS
Q---------------NSQAVT---GE--HA----------QTQAGTQTQTV--------
-----------------------------------------E------------------
------------------------------------------------------------
----------------------QDRSQTVSHGGAGE------------------------
---------------------------------------------------QGQTQ----
TQPGSGQKWIQVSNPEA-RE----------------------------------------
---------TVPG-------------------------GQAQNGASTESGRQEWSSTHPR
HNV----------TEGQG-----------------------DIQPT--------------
-------VVGEEWVDDHSRET---AVFRLDQGN----LHT--------------------
------------------SVSSAQGQDAAQ------------PE-EKRGIT-ARE-----
----------L--------------------------YSYLRSNKP--------------
------------------------------------------------------------
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-------------

----------------MPRLLRDVLCVIETFHKYARGNGD-EAVLTCRELKQLIQGEFGE
NLQPPV------------IHAIDRDLNLQDIDSNDTISFD-----------E-FVL-A--
-I---------------F-S-L-L-N-F-C-YLD----IQS-----SLN---S-EPRQ--
-VSTL-GE-KPDD------MDLQVTS---VT---------GQQKEG---LSPT-------
-----------QKKV----------------VIPS----------------------VMA
SSPQLGPKEG----------------GAVEYNRVD-PQGDTTTHKLPIKASEHSDP----
---KDQHL-------------------------------------------------EGG
-------EQSQEVAQDVLSRGNSGAQ-LETKK---PTGS-AQNSSLIK-REG-QDKEILR
EGD-KP----VREQSDT------KTREEF---------------REQEGKLE--------
--------------------------------------------TQNHPLEETRERPSK-
-----------------DQ----------EVAGEK-GGKD----------HSKTQELPL-
------Q------------------RKDE-P-------------HSDYV---DLS-----
EQAAAQKPFQTQ---KSTDPEDD--SGT----AESQEPEEDAS------------RMLPE
------------TKN--LAEPEDDGR---------------------TSETQEPPVQE--
------------------------------------------------------------
------------------------------------------------------------
------------------KEYEKKDMPLQGDSRNV----SETPTVR--------AERKEL
RGPEVHQTAGQ-KE--------------------SER---------------------RT
QSPVL-------------NGQTEDGKY--WELQESS------SKEKNAEEDSKT------
-----------------------------------------QELSSEGGDQK-----HSE
I--------------E-------GA----I-SPEEEARHAEESTVEALESSKNASATEGI
PGARE----------RTQE-----------------------------------------
--------------------------------------------LTPLGK-QSGEKNKRV
AKTHYK--PVKENDCYQ-----------------------------------GEDPEPKV
TQNGEGSSETPSSLTPESGESSLETS---------------D------------------
--------LPVQGDSQ------------------SQKDPPGASE---------QGSHNNN
PDT---------------------------------------------------------
------------------------------------------------------------
---------------------------------------------QKQVALGEKNRSQEA
V------VLAVR------------------------------------------------
--EDEQLTQEQVWPVGEEHK-S--------QGSG-----T-KGPGPAVEPDGHPDN----
------------NEKTLETEFPDALNAG--FADQLPVRQLSSEKD---------------
-------------------SRKEPKVQGSSTKEEEDGAPE---ALVKNLDEYSSVSP---
--K------E-------PAVL--EGNECPQELL--------LAKN-VHDSSVPKSGLKER
MQRDQELYSVERVAVHSSALYKYLQEKILQQIDITQK--------------------KHR
D---------------------------------QAQTTSVSSPE---------LRNDQI
SAFLTNEISDCPAFFTGSQALQ---------------QCTRELLLDEDPADAQLTAAPQA
LEDKQSHPQREELEPQREISTP----------------------------------K---
-----------------------------Q------------------------------
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-------------

----------------MPKLLQGVITVIDVFYQYATQHGE-YDMLNKAELKELLENEFHQ
ILKNPND-----------PDTVDIILQSLDQDQNKKVDFT-----------E-YLL-M--
-I---------------F-K-L-V-Q-A-G-NKI----IRK---D-YCQ---T-------
SGSKLRDDINQ----------HQEEQEETEKE--------E---------DKR-----QE
SSFSHSSWSAG-ENDSYS---NNV-RA---------------------------------
------------------------------------------------------------
----------------------------------------R--IKHGTESIS-RRL----
----------------------------------------------------SF------
---QRD-------------------FSGQH------------------------------
----------------------------------------NSC-SGQSTSY---------
-----GE----QN--------------------------S--------------DSRQY-
---------SGRSQHGSGSEQSPSYGQHGSGSGWS-------------------------
---------------------------------------------SSSDPHGSGSGQSSG
-------------FG-QHESS-----S--------------------GQSSG--YSQHG-
S-----D--SGHSSGYGQH----------------GSRSGQSSRGER-------------
--------HRSS------------------------------------------------
--SGSYSSYGQH-----------GSGS--------------------------------R
QSSGH--------G--RQESGSGQS------P-S--------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------YGQHGS-----
-------G-------SGHSSSHSQHG-----------SGSSCSSSHGHY-E---------
S---GSGQA-----------S---------------------------------------
------------------GFGQQ---E----------S------GSGQSSGYS-------
----------QH-AS-------GSGHSSS----------------Q--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------G--------------------------------------------
---------------------------------RH-----GS------------------
------------------MSGQ-SS-----------------------------------
------------------------SG---Q-------HGS-SS-----------------
----------------------------------GQS-----------------------
---------SSNGHHES-------------------------------------------
------------------------------------------------------------
--------------------------ASRHSSGCGRH-----------------------
-------GSGSGHSPGHAQHGSGS----------------------GQYPSYGRH-----
----------GSGSSRSSSSGPRGSG-----------------SGQS---------SGF-
GHH--ES-S-S--------GQSWGYSQ---------------------------------
---HG-------------------------------------S-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------GSG---
--HSSSY---GQHG-----SRS-----------GQ--SS-R-----------G-------
-------------------------ERHQ--------SSSG-SSSSY--GQHQS------
-------GSR------------QYSGHGPHGSGPG------------QSPSPSRGR----
---------------------------------------------H-GSGSRQYSSYGPH
-GSGSGQ---------SSSRGPYESGSGHSSGLGQQESRSGQSS--------GYG-----
----------QH------------GSSSGHSSTNGQHGSTSGQS-SGCGQHGASSGQSSS
HGQHGSGSTQPSAYGRQG-SGSSQTPSHG-----------------------RH------
GSGS-RHS----------------SSYGQ---HGSRS------------------G----
----------RSSSNGPHGSG---------SGQSS-------------------------
--GFSQ-----------H------------------------------------------
---------------ES----SSGQS----------------------------------
------------------------------------------------------------
----------S-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---GYSQ-----------HGSGSGHSSGYGQ-----------------------------
-------HGSW-SG--Q-----------------------------------SSRGE-RH
--R-SSSGSSSSYGQHGSGSHQSSGHGRRG-SGSG--------QSP-SRGRHGSG--SGH
SSSHGQHGSGSSCSSR-----------R-GHYESGLGQASGFGQHQSGSGQSSGYSQHAS
GSGHSSSQG--------------RHGSLSGQSSSSSQHGSSSGQSSTYGQHESASH----
------------------HSSGRGRQGSGSGQS---------PGSGHHGSGSGQSPSYGR
HGSG--------------------------------------------------------
---------------------------SSRSSS-SGPRGSGSGQSSGFGHHESSSGQS--
--WGYSQHGS--------------------------------------------------
------------------------------------------------------------
----------GSGH--SSGYKQHGSRSAQ-------------------------------
------------------------SSRGERHRSSSGSPSSYGQHGSGSHQYSGHGTHGSG
SGQSPSPSRGQHGS----------------------------------------------
-------------------------------------------GSRQYSSYGPHGSGSGQ
S-----S-----------------------------------------------------
-----------------SRGPY--ES----------------------------------
------------------------------------------------------------
------GSGHS------------------------------------------SGLGQQE
SRSGQS-SGYGQHGSSSG--HSSTHGQHGSTSGQS-SSCGQHGASSGQSSSHGQ------
--------------------------H-----------------GSGS--TQSSGYGRQG
SGSGQTPSRG--------------------------------------------------
-----------------------------RHGSGSGHSSSYGQH----------------
------------------------------------------------------------
----------------------------GSGSGRSS-------SNGPHGSGSGQSSGF--
-GQH----------------------------------------------ESSSGQSSGY
SQHG--------------------------------------SGSGHSSG----------
----------------------------YGQHSS-RSGQSS----TGERHRSSSG-----
-------------------SSSSYG--------------QHGSG----------------
----------------SRQSSGHSQ-----------------------QGSRSGQSPSPG
P-HGSGSGHSSSHGQHRSGSSC--------------------------------------
----S-----S-------------------------------------------------
SRGHYESG----------------------------------------------------
-----------------------------------LGQSSALGQHES-GSGQSSGYSQH-
----GSGSRHSSRHGRHGSTSGQSSSSGQHHSSSGQSSSYGQHESASRQSSRRSR-----
--------H-GSGSGQSP----------------GR------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---GQHVSGSGQSP-----------SYGRHGSGSGRS-----------------------
-----------S-SS-------G-------------------------------------
------------------------------------------------------------
-PHGSGSGQ--------------SSGF------------------------GHHESSSAQ
SS--GYSQHGS------SSGHSSGYGQH--------------------------------
-------------GSRSGQ-SSRTERHGTSSGSSSSY---GQHGSGSRQSSGHGRQGSGS
GQSPSPSRGQHGSGSRQSSS---------YGPHGSGSGQSSSRGPYESG-SGYSSGLGQQ
ES--------------------RSGQSSGYGQH---------------------------
------------------------------------------------------------
----------------------GSSSGHSSTHGQHGSTSGQSSSCGQHGASSGQ-SSSHG
QHGSGSTQ--SSGYGRQGS--GSGQTPS---RSRH---G--------------SGSGHSS
SYSQHGSHSGQSSSNGPHGSGSGQSSG--FGQ---------HESSSGQSS----------
-----------------------GYTQHGS--------G-SGHSSGYGQHGSWSEQSSRG
ERHRSSSG-------------------------------------------------SSS
S-----------------------------YGQHGS-GSHQSLG----------------
----------HGRRGSGSGQSP-----------------SHGRHGS--GSGHSSSHGQH-
-GSGSSCSSSRGH-YESG------SGQA--------------------------------
------------------------------------------------------------
------------------SGFGQHESGSGQSSGYNQHASGSGHSSSQ-----------GR
HGSLSGQSSSSSQY------------------------------------GSNSGQSSSY
GQHGPASRHSSGHGRHGSGSGQS------PGC---SQHGSGSGQSPSYGRHGSGSGRSSS
SGPHGSGSGQSSGFGHHESSSAQSSGYS---QHGSS--SGHSSGYGQHGSTSRQSSRTER
HGTSSGSSSSYGQHGSGSRQSSGHGRQGSGSGQSPSPSRGQHGSGSRQSSSYGPHGSGS-
-------GRS-----SSRGPYESGSGHSSGLGQQESRSGQSSGYGQHGSSSG--------
-----------------------------H------------------------------
----SSTHGQHGSTSGQSSSCGQH-GASSGQSSSHGQHGSGSTQSSGYGRQ---------
----------------------------------GSGSG---------------------
------------------------------------------------------------
--------QTPSRSRHGSGSGHSSSYGQHGSGS-----------------GRSSSNGPHG
SGSGQ-----------------SSGFGQHESSSGQSSGYSQH------------------
--GSGS-------GHS------SGY------GQHGSWSGQSSRGERHRSSSG--------
SSSSYGQRGSASHQSSGHGRRGSGSGQS----PSHGRHGSGSGHSSSHGQHGSGSSCSSS
RG-HYESGSGQASGFGQHESGS--GQSSGYN-----------------------------
----------QHASGSGHSSSQGRHGSLSGQSSSSSQYGSNSGQSSSYGQHGPA------
--------------------SRHSSGHGRHGSG-------------SGQSPGCSQHGSGS
GQSPSYGRHGSGSGRSSSSGPHGSGSGQSSGFGHHESSSAQSSGYSQHGS-SSGHSSGYG
QHSSRSGQSSRTERQGTS---------------------SGSSSSYGQHGSGSRQSSGRG
RQGSGSGQSPSPSRGQHGSGSRQSCSYGPHGSGSGQSSSRGPYESGSD---HSSGLGQQE
SRSGQSSGYGQH------GSSSGHSSTHGQHGSTS--GQSSSCGQHGASSGQS-SSHGQH
GSGSTQSSGYGRQGSGSGQT--PS-------------------RGRHGSGSGHSSSYGQH
GSGSGRSSSNGPHGS---GSGQSSGFGQHESSSGQSSGYSQHGSGS--------------
--------------------GHSSGYGQHSSRSGQSSTGERHRSSSG------SSSSYGQ
HGSGSR--QSSGHSQQGSG----SGQSPSPGPHGSG--SGHSSSHGQHGSGSSCSSSRGH
YESGLGQASALGQHESGSGQSSGYSQHGSG----SGHSSSQ--------------GRHGS
LSGQ--------------------------SSSSSQYGSNSGQSSSYGQHGPASHHSSGH
G-------------RHGS-------------------GSGQSPGCSQHGSGSGQSPSYGR
HGSGSGRSSS--------------------------------------------------
------------------------------------------------------SG-PHG
S-GSGQSS-GFGHHE-------------SSSDHS----LTTTFKWSLSLPNSTSPYEYIQ
EQRSQY------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-------------

----------------MPELLQSIVTVIDIFYQYATQDEE-CARLNKAELKELLENEFHQ
ILKNPDD-----------PDTVDIIMQSLDRDHNRKVDFT-----------E-YLL-M--
-I---------------F-R-L-A-Q-A-C-NKI----ISK---D-YCQ---A-------
SGSKQRDYSHW----------HQEEQSETEEE--------D----------KG-----QE
SSSSYSSWSAG-ENDSSS---RGS-RG---------------------------------
------------------------------------------------------------
----------------------------------------S--IKHRS------------
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-------------

----------------MAQLLNSILNVVEVFHKYAKENGD-CALLCKEELKQLLFTEFGD
ILRRPND-----------PETVETILDLLDRDRDGHVDFH-----------E-YLL-L--
-V---------------F-Q-L-V-Q-A-C-HHK----LDN---K-SRG---G-------
RTSQ-QERGQE-G-----ARDHKVPGN-IGR---QH----RQRHEEERQ-----------
-NSHHS-QSERQDRD---------------SH--------------------------YG
QPERQDRES--HHGHQFERQDRDSHHGQP---------------ERQDRESHHSQSERQD
KDCSLDHSERQ------------SQDSSSGENLS-----------H--KSSS--GQAKWQ
G--HI-------F-------------ALNQCE------KP------VQ-----------N
SHYGQ-------------------------------------------------------
---------------SE---------------------------RVAQ-Q----------
------------------------------------------------------------
----------------------S-----ETLGQDSCFNQTNQQKSSSYY---RQSGRLGQ
ESGCSQTDRQG---QSSYYGQTDR------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------KGQSSHYGQTDR---------
------QGQSYH----YGQTDR--QGQSSH-----YGQTDRQGQSSHYGQTDRQGQSYH-
------------------------------------------------------------
------------------------------------------------------------
-------------------YGQTDRQDQSSHYGQTDR-----------------------
-----------Q------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-DR-QGQSY------------HYGQPER--------------------------------
----------------QGQS-----------------SHYGQTERQGESYHYGQPDRQGQ
SSHY--DQTNRQGQSSHYGQTDRQGQSSHYGQKDRQGQSYHYGQTNRQGQNS--------
----------HYGQSQT---------G---EI--QEQNKYFQGTEG-TR-----------
--Q-ASYVEQSGRSGRLSQQTLGQEVY-QKQGQGFQSRYSQQIGHQVWEP----EEDSQ-
-----------HHQHKLLAHI--QQERP--LCHRGRDQQSCSS-----------------
-------------------KQGQRQAQTRQSHGE--------------------------
------------------------------------------------------------
--------------------------R---------------------------------
------------------------------------------------------------
----QSHWA------EEEQGPQ-----------------NRDIHSHEGQEGPYGTQDRRT
HEEQ--NHQRDRQTHEDEQNHQ--------------------------------------
--RRDRQTHEDEQNR-Q-------------------------RRDRQTHKEDSKPTKFFL
FFCFLG-------VSR--------------------------------------------
------------PSRDETGKPMKMSRAIR-----------G-------------------
--------------------------------ETGKPTKMSRTVRDETGKP---------
-----------------------------------TKMSRTVRDETGKPMKM-----SR-
TIRDE-------------------------------------------------------
T-----------------------------------------------------------
-------GKPMKMSRTVRDETGKPRKRIKTISN---------------------------
-----------------------------------------------N--RIDK------
--------------------------------------------TMRRKRAI--------
--------------------KDLRIK-------------NLK------------------
------------------------------------------------------------
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-------------

----------------MSPLLRSVIDIAEIFDHYASHSCD-GASLSKKDLKNLLERELGT
VLQRPQD-----------PETVDLTLALLDRDSNGRVDFN-----------E-F-L-L-F
-L---------------F-K-I-A-Q-A-C-Y--Y-A-L-D-Q-T-SG--L-D------E
K-RN---------------V-S--QD-RRQ-ED-Q-R-----------------------
-------------------------------RF-------------------------EP
QDVQRDEERG-----HQSRQKRHE----QEE--RT-DEQR----KRQE-RLEQE------
--------------------------------------------------EQRRELQEL-
-------------------------------------EERLAEKEPLSWSQGPDAEEFSE
EENLRE----RQELKSKDQ---------TE------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------ERRL--------QKRR-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------R--EEV------SD-----
------------------------------------------------------------
-----------------------------------------------------------P
QL----------------------------------------------------------
------------------------------------------------------------
-----R------------------------------------------------------
------------------------------------------------------------
-------------------------RDAQLR-----------------------------
----------------------------------------RD-PQLRR----EQELV---
---------------AE-EE---EQT---------------RL-----QEPDDSFTRRWQ
QQLESE-------------------------------AEARQNK---VYSR---------
PRR-QEAE-----ERQLREQGQR-------------------------------------
------------------------------------------------------------
-------------------------RDLRRQRLAE-------------------------
---------------------EER----------LEQEQRFRERL---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------QRGRQYQEEDLQQEEER
LQQEE------------------------ELLQQEEERLQ---Q------E------RRQ
Y------------------------------------QEEDLQRLRDVDQRRDLKW----
QWQPEKENEARRHRLFSKRRQDEERTRQLED-SLEQER---------------------R
ELEQETRRRLQRDRQLLEEEQ----LQREH---QREARRRDENIQEEEQLLRD-SR---R
RPQERDAKFLEEEKQLRKRRE-----------------------EHRRRQEQERQFQEEE
ELRHQEREKELRQERGRNSCEEQELRQQLEADQRRQELREEEQRRQQRDRRVRQEEELRQ
ELR------------------EEEQRRQQRDRRVRQEEELRQELR-----EEEQ------
----------R-------------------------------------------------
------------------------------------------------------------
----RQQRDRRVRQEEELRQELREEEQRRQQR------------------------DRRF
RQ--------E-EEL---------------------------------------------
-----------------------------RQELREEEQLRHQ------------------
-ERDRKSRGE--------------------------------------------------
-----------------------RELRQ-----ELEEEK-----FLREQELRRDRK----
------------FREAE-RRQ--------------------------------------E
LEEEQLRHQKCDRKFREA-ERRQELEEEQLRHQKCDRKFREAER----------------
----------------------------------RQ--------------ELEEEQLRHQ
ERDRKLREA--ERRQELEEEQLRHQERDRKLREAE-RRQELEEEQLRDRKLRA---EEQL
RGERE-------------EER-------RKFRREQEFSQELEEEQ----PRDRK------
------FRREQELRRDRKFHEEEERRQQL--EEEQLRHQERDRKFREAQ-----------
-------RRQERDRKFHEEERL-QELEEEQLRDRKLRVEEQLRREQEEER----------
---------------RQFRQELEEEQPRDRKFRREQEL--------------------RR
DRKFHEEERLQELE---EEQLRRQERGR-KFLEEEERRQ-----------------ER-D
RRFRGEPELRKEREGQQRQQLRFE--------EQK-------------------------
-----RRHQELEQQLRQERDRKFREEKQLRQ--EREELQL----RRQKRDGQYPAEE---
-----------QFARDKIRR-QEQEQRQEEEQKRRQELERKFQEEQ-IR-----------
-----------------------------RQAEQRRRQILE-----SGTRQFANVPV---
-------------------RSSPLYEYIQEQRSQYRP-----------------------
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-------------

----------------MPQLLRNVLCVIETFHKYASEDSN-GATLTGRELKQLIQGEFGD
FFQPCV------------LHAVEKNSNLLNIDSNGIISFD-----------E-FVL-A--
-I---------------F-N-L-L-N-L-C-YLD----IKS-----LLS---S-ELRQ--
-VTKP-EKEKLDD------VDVQATT---GD---------GQWTVG---TSPT-------
-----------QEKR----------------MLPS----------------------GMA
SSSQLIPEES----------------GAVGNNRVD-PWREAKTHNFPGEASEHNDP----
---KNKHL-------------------------------------------------EGD
-------EQSQEVAQDIQTTEDNEGQ-LKTNK---PMAGSKKTSSPTE-RKG-QDKEISQ
EGD-EP----AREQSVS------KIRDQF---------------GEQEGNLA--------
--------------------------------------------TQSSPPKEATQRPCE-
-----------------DQ----------EVRTEK-E--K----------HSNIQEPPL-
------Q------------------REDE-P-------------SSQHA---DLP-----
EQAAARSPSQTQ---KSTDSKDV--CRM----FDTQEPGKDAD------------QTPAK
------------TKN--LGEPEDYGR---------------------TSETQE-------
------------------------------------------------------------
------------------------------------------------------------
------------------KECETKDLPVQYGSRNG----SETSDMR--------DERKER
RGPEAHGTAGQ-KE--------------------RDR---------------------KT
RPLVL-------------ETQTQDGKY--QELQGLS-------KSKDAEKGSET------
-----------------------------------------QYLSSEGGDQT-----HPE
L--------------E-------GT----A-VSGEEAEHTKEGTAEAFVNSKNAPAAERT
LGARE----------RTQD-----------------------------------------
--------------------------------------------LAPLEK-QSVGENTRV
TKTHDQ--PVEEEDGYQ-----------------------------------GEDPESPF
TQSDEGSSETPNSLASEEGNSSSETG---------------E------------------
--------LPVQGDSQ------------------SQGDQHGESV---------QGGHNNN
PDT---------------------------------------------------------
------------------------------------------------------------
---------------------------------------------QRQGTPGEKNRALEA
V------VPAVR------------------------------------------------
-GEDVQLTEDQEQPARGEHK-N--------QGPG-----T-KGPGAAVEPNGHPEAQ---
---ESTAGD--ENRKSLEIEITGALDED--FTDQLSLMQLPGKGD---------------
-------------------SRNELKVQGPSSKEEKGRATEAQNTLLESLDEDNSASL---
--KIQLETKE-------PVTS-EEEDESPQELAGEGGDQKSPAKK-EHNSSVPWSSLEKQ
MQRDQEPCSVERGAVYSSPLYQYLQEKILQQTNVTQE--------------------EHQ
K---------------------------------QVQIAQASGPE---------LCS---
-VSLTSEISDCSVFFNYSQASQ---------------PYTRGLPLDESPAGAQETPAPQA
LEDKQGHPQRERLVLQREASTT----------------------------------K---
-----------------------------Q------------------------------
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-------------

----------------MSHLLSSILSIIEVYYKYTSQDQD-CNTLCKRELKKLLENEFRP
ILKNPDD-----------PDTVEIFMQMLDRDHDKKVDFI-----------E-FLL-M---I---------------F-K-L-T-M-A-C-NQS----IGK---E-YCQ---A-------SGSQKQHPHHH----------RQE-QSKTKEE--------EE-------E--------EETDSSNSSWSAG-EEPRSH---TGR---SKKIRHRS-----------------------KSNSRG-------H------G-KLDR----SS------SSGYKDIFG-RKQHESKP---------------------------------RHSKR--------S--ENMENRSSS-SDLEKMRP--------------------------KRQQ---------------------QD---------APR-------------------GSGTS----------------------------------------------------------------------DRQ-ARDASS-RGRDITSR-----RQ------QQDSSR-----------RSGSGQR------------------QSSDS----------RRSRTRGSSSRQQPESSTHSTSGQRQSSDSRSRSRGGSHR---RQQNDSSRQSGSGQR---ET---RD----------------------------ASSRGRGSGSSQRQS-------------SD-RRSTS--------------------------RRRSS--RSQQD-D--------ISRQSGSGQRE---------------SSDSRSRGRGESSRRQQQDA-PRGSSTSDR--QARD------------------------------------------------------ASSRGRD-----------TT-S--------------------------------RREQQD--------S--SRRSGSGQR------Q-S------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S-DSR-----------------------------RSSIQG-----------SSSRQQP--------------------ESSTH-----------S---------------------------------------------------------TFGQR---Q----------S------SDSRSRSRG-----------------GS-RR-------RQQHDSS----------------RQQQPDSSRQSVSSQRQTTDASSRGRDVPRRRQQQDSSRQ-S-----G---------SSQRQSSDRR--------------------------------------STSRR-----RSSRSQQ---DDISRQSGSGQRESSDSRS--RGRGESSR----RQQQDAPRGSSTSDRQARDA--------SSR---------G----RDI---------TSRRQQQDSSRRSGSGQR--------QSSD-------------SR--------RSRT--------------------------------------------------------------------------------------------------------------------------------------------------------------------Q-GSSSRQQPE----SST-HSTSGQRQSSDSRSRSRGGSRRR------------------------QQNDSSRQSGS-D-------QRE--------------T------------------RDAS----------------------SR--GRGVPSRRQQQDSSRQ------------------------SGSSQRQSSDRRSTSRRRSSRSQQ------------------------------D-DISRQSGSGQRESSD----------------------SRSRGRGES------------------SRRQQQDAPRGSS-----------------TSDRQARDASSRGRDITSRR--EQQDSSR----------WS----GSGQ----RQSR---------EADRRQQPDSS-RQSGSS-------------------QRQTRDA-------------SS---RGRDV-------------------PSRRQQQ---------------------------DSSRQSGSSQRQSSD---RR----------------ST-S---------------RRRSSRSQQ-----------DDIS--------------------------RQSGSG-------QRESSDSRSRGR------------------------------------------------------------------------------------------------------GE--SSR---RQQQDAPRGSSTSDRQ---A-----------------------RD-ASSR-----------G-------------------------RDITSRRQQQD----------SS-RRSGS--GQRQS-------------SDS------------R--RSRTQGSSSR------------Q--QPESST-------------------------------------------------HSTSGQRQSSDSRSR---SRGG---------S--RRRQQNDSSRQSGSGERETRDASSR--------GRGV-PSR---------RQQQDSSRQSGSSQRQS-SDRRSTSRRRSSRSQQD-DTSRQSG--SGQRESSDSRSRGRGESSRRQQQD----------AP--------R--GSSTSDRQA--RD------ASSRGRDI----------------TSRRE---QQDSS------------------R--------------WSRGRGEAGRR---------QQPDSSR-Q----------------------SGSSQ-----------RQTR----D-------------------------------------------------AS----SRGRD--------------------------------------------------------------------------------------------------------V----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PSRR-----------QQQDSSRQSGS-----------------------------------------------------------------------------------SQRQS-SD--RRSTSRRRSSRSQQD-DISRQS--------GSG--------QRE-SSDSRSRG--RGESSRRQ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PILKNPDD-----------PDTVEIFMQMLDRDHDKKVDFI-----------E-FLL-M--
-I---------------F-K-L-T-M-A-C-NQS----IGK---E-YCQ---A-------
SGSQKQHPHHH----------RQE-QSKTKEE--------EE-------E--------EE
TDSSNSSWSAG-EEPRSH---TGR---SKKIRHRS-----------------------KS
NSRG-------H------G-KLDR----SS------SSGYKDIFG-RKQHESKP------
---------------------------RHSKR--------S--ENMENRSSS-SDLEKMR
P--------------------------KRQQ---------------------QD------
---APR-------------------GSGTS------------------------------
----------------------------------------DRQ-ARDASS-RGRDITSR-
----RQ------QQDSSR-----------RSGSGQR------------------QSSDS-
---------RRSRTRGSSSRQQPESSTHSTSGQRQSSDSRSRSRGGSHR---RQQNDSSR
QSGSGQR---ET---RD----------------------------ASSRGRGSGSSQRQS
-------------SD-RRSTS--------------------------RRRSS--RSQQD-
D--------ISRQSGSGQRE---------------SSDSRSRGRGESSRRQQQDA-PRGS
STSDR--QARD-------------------------------------------------
-----ASSRGRD-----------TT-S--------------------------------R
REQQD--------S--SRRSGSGQR------Q-S--------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------S-DSR---------
--------------------RSSIQG-----------SSSRQQP----------------
----ESSTH-----------S---------------------------------------
------------------TFGQR---Q----------S------SDSRSRSRG-------
----------GS-RR-------RQQHDSS----------------RQQQPDSSRQSVSSQ
RQTTDASSRGRDVPRRRQQQDSSRQ-S-----G---------SSQRQSSDRR--------
------------------------------STSRR-----RSSRSQQ---DDISRQSGSG
QRESSDSRS--RGRGESSR----RQQQDAPRGSSTSDRQARDA--------SSR------
---G----RDI---------TSRRQQQDSSRRSGSGQR--------QSSD----------
---SR--------RSRT-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-Q-GSSSRQQPE----SST-HSTSGQRQSSDSRSRSRGGSRRR-----------------
-------QQNDSSRQSGS-D-------QRE--------------T---------------
---RDAS----------------------SR--GRGVPSRRQQQDSSRQ-----------
-------------SGSSQRQSSDRRSTSRRRSSRSQQ-----------------------
-------D-DISRQSGSGQRESSD----------------------SRSRGRGES-----
-------------SRRQQQDAPRGSS-----------------TSDRQARDASSRGRDIT
SRR--EQQDSSR----------WS----GSGQ----RQSR---------EADRRQQPDSS
-RQSGSS-------------------QRQTRDA-------------SS---RGRDV----
---------------PSRRQQQ---------------------------DSSRQSGSSQR
QSSD---RR----------------ST-S---------------RRRSSRSQQ-------
----DDIS--------------------------RQSGSG-------QRESSDSRSRGR-
------------------------------------------------------------
-----------------------------------------GE--SSR---RQQQDAPRG
SSTSDRQ---A-----------------------RD-ASSR-----------G-------
------------------RDITSRRQQQD----------SS-RRSGS--GQRQS------
-------SDS------------R--RSRTQGSSSR------------Q--QPESST----
---------------------------------------------HSTSGQRQSSDSRSR
---SRGG---------S--RRRQQNDSSRQSGSGERETRDASSR--------GRGV-PSR
---------RQQQDSSRQSGSSQRQS-SDRRSTSRRRSSRSQQD-DTSRQSG--SGQRES
SDSRSRGRGESSRRQQQD----------AP--------R--GSSTSDRQA--RD------
ASSRGRDI----------------TSRRE---QQDSS------------------R----
----------WSRGRGEAGRR---------QQPDSSR-Q---------------------
-SGSSQ-----------RQTR----D----------------------------------
---------------AS----SRGRD----------------------------------
------------------------------------------------------------
----------V-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---PSRR-----------QQQDSSRQSGS-------------------------------
----------------------------------------------------SQRQS-SD
--RRSTSRRRSSRSQQD-DISRQS--------GSG--------QRE-SSDSRSRG--RGE
SSRRQ-------------------------------------------------------
------------------------------------------------------------
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-------------

----------------MSPLLRSICDITEIFNQYVSHDCD-GAALTKKDLKNLLEREFGA
VLRIVHCKFFFFFFFFFFFLTVDLILELLDRDRNGRVDFN-----------E-F-L-L-F
-I---------------F-K-V-A-Q-A-C-Y--Y-A-L-G-Q-A-TG--L-D------E
E-KRA-R-C-D-G-K-V-SL-L--QD-RRQEED-Q-R-----------------------
-------------------------------RF-------------------------ES
RDRQLEEEPG-----QRRRQKRQE----QER--EL-AEG-EEQSEKQE-RLEQRDR----
--------------QRR---------DEELWR------------------Q-RREWKEQE
E--R----------------RAEEEQ-LQRCK-------------------GHETEAFPD
EE-QQR----RRELQ---------------------E---LRRERREEKQQQRR------
-------------E------------------R--QERVLQEEEEKEW-RKRERVLRQEE
-----------------------------K------LQEE-------------E--PQL-
-----QRELQE-EEEQL--------QKLERQ---------------------ELKRERQA
EE----Q--QQQ---RLRREREEERREQ-QL-RREQEE----------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------ERREQEERREQ--RL
KRE-------QE-----------ERRDW--------LKREEEE-----------------
-------------E--RR----EER------L-KREEQQERREQQ---------------
------------------------------------------------------------
---------------------------------------------------------ERR
EQQERREQRLKRQEEE--------ERREQLLKREEKERLQQ-------------------
-------------------------------------------------------DRREQ
RLKRGQEE-ERRDQLLKREE-EEERLEQEERR--EQRLKR-EQ-------EE--------
----------RREQRLKREEEERLEQEER-R-E-QLE-ERRQ-QWLTR----EQEL----
---------------A--EE---KQE---------------QA-----RERIKSQTPKWQ
WQLESE-------------------------------ADARQSK---VYSR---------
PRK-QEGQ-----RRSQEQEEKRR------------------------------------
-------------------RRER---E----------L---------QW---Q-------
----------EEEPARRQQQEEEQRGDFTWQWQAEE-----ERQRGRQRLS---------
-----A-RPSLREQRERQLRAEER----------QQREQRFLQEEE-KEQRRR--QRSE-
REKELQFLEEKEQLQRRERAQQLQEEGYGSQEDQERRRSPEQRRDQKWRWQ--LEEER--
-K---------RRHHTLYA-------KP------ALRGQLRKEQQ----L-----QQQE-
------E-EQLQ--REE-REKRRRQEQERQYREE-EQL--------QQEE----------
------------------------------------------------------------
--------------------------EQLQQ-------------------------EEEQ
LLR---------EE-REKRRR---------------------------------------
--------------------------------QERERQ-YREDEELQQEEE-QLLGEE--
-REKRRRQELERQYREEEELQQEEEQLLRE--------------E---------REK-KR
RQERERQYRKKDELQQEEEQLL-------REEREK---RRRQERERQ-------------
------------------------------------------------------------
------------------YREEDEL---QQEEKQL---LRDE------------------
------------------------------------REKRRRQELEKQYREEEELQ----
--Q-------------------------------EEEQLL---RE--EQEK-RRQERERQ
Y-----------------------------PEEEELRHQERKRRYRDEDQRRDLKW----
QWELEKDNAVRNNRVYCKRRENE-PFRQLED-SQVRDRQSQQDLQPLLDEPQ------ER
DGEQERRRWQQRDRHFPEEEQ----LERE--EQKE-AKRRDRKFQEEKQLLRE-EREEKR
VRRERDRKFREEEQLLQEREEQLLQEREE-------QLLQEREEQQLRRQERDRKFREEE
LR---------RQERERKFLEE---------KQQLGRQEREQQLRQFRDRKLRQEEQLHQ
ERE------------------EQQLSRQEQERKFLEDEQQLARQE-----RQQQ------
----------LSQERYRKFREEEQLLQEREEQQL-RR---------------QERDGKFL
EEEQ--------QLRRQ-------------------------------E----------R
ERQLRHDRDRKFREEEQLLQEREEQQLRRQ------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------EREQ-----
-----------QKFREE---EQQLRRQERDRK------------------FLEEEQQLRR
QEREQQLRQDRDRKFREEEQLLQEREDQQLRRQERDRKFLEEEQQLRRQEREQ-QLRHDR
DRKFREEEQLLQDREE-QQLRRQERDR---------------------------------
----KFREEE---------QQLHRQERDRKFLEEE--------QQLRR------------
------------------------QERDRKFLEEK-------------------------
-------QQLRRQERDRKF---QQLLQER--EDQQLRRQERD------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------R-KFLEEEQLRQEREE-------QQLRRQER-D
RKFREEEQLPQEREEQ--QLRRQDRETKYSWEEEQLQL----KKQE--------------
------------------------------------EQRLRQE-----RDGQYRGEE---
-----------QFATQEKSRRQAQELWQEEEQKRRQERERKLWEEH-LRSEQEEEQRRR-
-----Q----V------RET--------QSQEGKGHGRLLE-----PGSHQFASVPV---
-------------------RSSPLYEYIQEQRSQYRP-----------------------
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-------------

----------------MPQLLQNINGIIEVFSRHTRTEGN-CTALSRGGVKRLLEQEFAD
VIV KPHD-----------PA TVDEVLRLLDEDNSGTMEFK-----------E-FLV-L--
-V---------------F-K-V-A-Q-A-C-FKT----LSESP-EGACG---S-----RE
SRSC-----QP-G----ASQELGE-GQGSNTEV--GRASRGQQREG--------------
-------SS-------------------------------------------------LG
QGRQA-----------SRGPAG---------------TETQTQD----------------
------------------------QDISSARVSSCDG------------------QSESQ
RQETE-SQKAEERGPAGQTQTAREDRSYQSRE------R--------------R-----S
ERQS-----QIREQDRAHQTSETV-TQ---------------------------------
----------------------------------------------TQT--SATQTLGQD
RGHKTGS--TQPRESTYGQTRGT----------------E--------------------
-----TQGQVRSQRSR-----VVTGGPVQTQ-------------AESPS-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---RMNPQPVEQDRSH----------------QTGRTSTQPRASTCGQTRAIDTQGQVRS
Q---------------TSNVET---GG--PI----------QTQAGSITQTV--------
-----------------------------------------E------------------
------------------------------------------------------------
----------------------QHRSQPASHTGTRE------------------------
---------------------------------------------------QGQTQ----
TQSGSGRRWTQVSNYEA-GE----------------------------------------
---------AVQG-------------------------GQAQTGASTVTERQDWNSRHPR
CSV----------TGGQG-----------------------EREPH-P------------
---RESTVVGQEWVDDHTRET---VIHRQDQGS----LQP--------------------
------------------SAPSAQGQDSAQ------------PE-GKRGIT-VQG-----
----------L--------------------------YSYFRSSKP--------------
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-------------

----------------MPKLLQGIVTVIEVFYQYATNDEE-CAMLNKAEMKVFLENEFRQ
IMKNPDD-----------PDTVNIIMQSLDRDHNKKVDFT-----------E-YLL-M--
-I---------------F-Q-L-A-Q-A-C-NKI----IGK---D-YCQ---A-------
SGSKQRDHSHQ----------HQEEHSETEEK--------D----------NG-----EE
SSSSHSSWSAG-ENDSYS---RGS-RG---------------------------------
------------------------------------------------------------
----------------------------------------R--IKHRP------------
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-------------

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----------------------------------MSLASSSEGH--SEDSGTEFAMTHE-
NSESSSRNQRGSTHAKSANRSRQSDSYQGQTGTHRQSDSTHRDS----GSTTRERQGHPQ
DQSEHIPRHSGSHQEKTAIHGQSDFAHRDSE-STTRERQG--------------------
------------RPREHSEDTSRHPGSHQG-----------------------------Q
TAIHRQSDSAHRDTGSITRERQGRPREHSGDIARHTGSHSGQRAIHRQSDSAHRDSGSI-
-------------------------------------------------------ISKRQ
GHHHEQSGDIARHP----------------------------------GSHSGQTATHRQ
SDAAHRDSGSITRERQGHHHEQSGNIARHSGTHQGQTTIHRQTESAHRDSGSITRDRQGH
HHEQSGDIARHSGTHQGQT-----------------------------------------
--------------------------------AIHGQPDSAHRDSGSITRERQGRPREQS
GDIARHPGSHS---------------GQTAIHRQSDSA-------------------HRD
SGSIT------KKRQGHHHEQSGDIAR---------------------------------
-----------------------------------------NSGTHQGQTAIQGQPDSSH
RDSGSITRERQGRHHGQSGDISRHSGSHRGQTAIKAQPDSAHRDSGSFTR----EG---Q
GHPHE-KSWD-------SSRHWETGHGQ--------------------------------
-----ISSGSGNTGHQGSSISQASDSEGQSE-----------------------------
------------------------------------------------------------
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-------------

----------------MAYLLRSVVTIIDVFYKYTKQDEE-CGTLSKDELKELLEKEFRP
ILKNPDD-----------PDTVDVIMHMLDRDHDRRLDFT-----------E-FIL-M--
-I---------------F-K-L-A-L-A-C-NKV----LGK---E-YCK---A-------
SGSKKHRRGHQ----------HQEEESETEEE--------E--------ETPR-----QK
SGFRFSSWSEG-EEHGHS---SGGSRGPAKHRRG--------------------------
------------------------------------------------------------
-------------------------------------------------SNS-KRLERQD
E--------------------------LSSS---------------------EE------
---S-R-------------------KKHHG------------------------------
----------------------------------------SIF-GHSWSSNKEKDGSRS-
--EELGE----KG----------------DKSYDSPSR----------------ESEEEY
------------------------------------------------------------
--------------------------------------ESGYR--LNHQGR---------
-------------EG-HSGLS---------------------------------------
-----------CGLEKNKY-----------------------------------------
--ELNYIQLRKG------------------------------------------------
--------------------------G--------------------------------E
QKL---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------G----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------Y------NTSSSGNS----
--------------------------------------------KIQSHVYG--------
------------------------------FSNSS-----GCCRPKN---ASSSCQ----
---ASRSQG--QG-------------------NQSCRTQSNC-Q---SGTSGGQGYGCVS
EG----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-Q-SSR-CCQPK----PRS-CS--------------------------------------
------------------------------------------------------------
---QSSS----------------------QR--GYGSKQCGQPQNCG-------------
------------------RQ---QRMGSSHSSCCGPY-----------------------
-------GSGATQSSGCGQQRMSS------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
----------------------------------------------------------CG
H-----------------------------------------------------------
-------------------------------------------SSSS--HQK--------
-----GCSSN------------GFSKGDQRASGSGH---------------SSCCE----
---------------------------------------------QHGTNSSQSSGFKQH
-GHESGQ---------SC--------------CGQHGTASSQSSG--------YS-----
----------------------QHRVGSGQSCHYGQHGSSSGQS-SSSGRHGSGSGQSSS
SRH---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
-------------------------------NRSGSSQSSGLEEHGSSSHQSHSSGHHGS
GSRQSSGSE--------------QHGAVSGQSSGSGKHETGPSQSSSSGHHGSGSQQHGG
G----S-----------GQSTGFGEHESSSGHS---------SSSGQHRSGSRHSSGSGK
HESGRSQSSGSGHHGSGSQQ--HGGG---------SGNSTGFGEHGSSSHPLPSSGQNES
SSGQSSRSERHGTGSGQSSGFGQHGSGSHQSSS-SGHNEYGSGQTSSSWPHGKGSGQE--
--SGYGEQES--------------------------------------------------
------------------------------------------------------------
----------GHGQ--SSSSWQHGTGPGQSS-----------------------------
--------SSEEEESR-----PGQSSSSWQHGKGSGQESGYGE-----------------
------------------------------------------------------------
----------------------------------------QEAGHGQSSSSWQHGTGAGN
Q-----S-----------------------------------------------------
------------------------------------------------------------
----------------------------------------------------SGYG----
--EHKSGPSHS------------------------------------------SRSWHHG
TGSGQS-LGFGQHGKGSHQSE--SSGHYESVSEPS--------------SSSWQ------
--------------------------H-----------------G---------------
NGSGESY-----------------------------------------------------
---------------------------------------GYG-E----------------
------------------------------------------------------------
----------------------------HESGHGQSS------SAWNHGNESGQSNGF--
----GEN--ESGPDQEG------------------------------------------Y
QQRE--------------------------------------SF----------------
-------HGQHR---HP-LSQH----EQHSQFGYGRSP-RS----PV-HPESSEGEEHSV
--------------VPRRYSGYGHGQ------------GQAGHQ----------------
----------------QR-ESGYGQ-----------------------RGRPQGPSQDSS
RQPQAGHGQPSQSGYGRSP--RRSQVHPEY-----------------S--E------GEA
HSEVS-------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------QR-
----HSGSSHCHSQGQ-----------G-----------QARH---QQRESVHGQRGRPQ
GPSQDSSRQPQAGQGQPSQSG------------SGR------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---SPRRSPVHPESSEGEEHSVV--PQRHSGSGHGHGQGQ---GQAGHQQRESVHGQRGR
PQGPSQDSSRQPQAGQG-----Q-------------------------------------
------------------------------------------------------------
-PSQSGSGRSP--R---------RSPV-------------------------HPESSEGE
EH-SVVPQRHS------GSGHGHGQGQG--------------------------------
-------------------------------------------------------QGQAG
HQQRESVHGQRSRPQGPFQDSSRQPQAGQGQPSQSSSGRSPRRSPVHPESSE--------
---GE------EH-SVVPQRHSGSGHGHGQGQG---------------------------
------------------------------------------------------------
----------------------QAG--H--------------------------------
-------QQRESVHGQPVRPEVPTQDSS----RQP---Q--------------ADQGQPS
----------------QSGSGRSQRRS--PVH---------PESSEGEEHS---------
-------VVPQ----------RNSESCHCHCHDQA---GHQQRESVHGQRGRPEGPSQD-
-----------------------------------------------------------S
S------------------R----------HPQAGQ-GQPSQ------------------
---------------SGSGRSPR-------------------------------------
--------SSPVH-PESS-----EGEEH--------------------------------
------------------------------------------------------------
------------------SVVPQRHSGSGHGHGQG-----------Q-----------G-
------------------------------------------------------------
-QAGHQQ-RESVHGQRGRPQGPTQDSSRKPQAGQGQPSQSGSGRSPR-------------
-----------RSPVHPESSEGEEHSVVPQRHSGSGHGHGHGQGQGQAGHQQRES-VHGQ
RGRPQGPSQ------DSSRQPQAGQGQP-------------SQSGSGRSPGRSPVHPES-
----------------------SEGEEHSVVPQRHSGSGHGYGQGQAGHQQR--------
------------------------------------------------------------
----ESVHGQRGRPQGPSQDSSRQ-----------PQAGQGQPSQSGSGRSPRRSPVHPE
SSEDEEHSVIPQRHSG----------SGHSHGQGQVHA----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------EHQQRE------SVH------GQRGRPQGPSQD-----------------
-SSRQPQAGQGQPS-------QSGSGRSPRRSPVHPESSEGEE-----------------
-----------HSVVPQRHSGS--GHG---------------------------------
-----------HGHGQG----QGQAGHQQ-RESVHGQRGRPQGPSQD-------------
----------SSRQPQAG--QGQPL-----QSGSGRSPRRSPVHPESSEGE---EH----
-----------------------------SVVPQRHSGSGHGHGQGQGQAGHQQRESVHG
QRGRPQGPSQDSSRQP-------------------------------QAGQ---------
--------------------------GQPSQSGSGRSPRRSPVHPESSEGEEHSVVPQRH
SGSGHGHGQGQGQAGHQQ-----RESVHGQRGRPQ--GPSQDS-----------SRQPQA
GQGQPSQSSSGRSPRRS-----PVHPESSEGEEH-----SVVPQRHSGSGHGHGQGQGQA
GHQQR----------------ESLHGQRGRSQSPFHPSHSIHWQSK--------------
--------------------CTIS--KKSSRLSGHYGRNHFQSTISGNQYDSSQSSRHGS
YGPQDYDYGQSGYGPSGRLRSNSQSSIPFSSAHRAT--NMEVLPCGQSFSPSDHVGTK-A
NEQIGELVFKYRESETGPDQSVDYYNLTESNSTTRGHECSH--------------GH---
--------------------------------------------------------SVVV
PEHSDDSDFNYGHSYNGKQQIC-----QSQPTVQSCFDDSQYILFQKHL-----------
ESPSFGNQSGFSPNERQL-------------------------YTCNESIDSYHLSSDSN
NRNQIYSSNNSFPNLYCIGTEQCIYLPSA------------------TILGEGTEGQEPG
YTQPGTIC-KYNQFLDGRKS-------RTRGNHE----TGKMKSGSAYLDSNTPLYTYVQ
EQKSYYFE----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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-------------

----------------MSPLLRSIFDITKTFNQYASHDCD-GAALSKKDLKNLLEREFGD
VLRRPHD-----------PESVDLILELLDRDCNGFVDFN-----------E-F-L-L-F
-V---------------F-K-V-A-Q-A-C-Y--Y-A-L-S-Q-A-SG--L-N------E
N--GA-K-C-E-G-K-G-IR-L--QD-RRR-EE-Q-R-----------------------
-------------------------------RF-------------------------EP
RDRQLEEERR-----LK----RQE----LEE--EF-AEE-EEQKENQE-RREQRLQ----
-------------R------------------------------------------RERE
E--R----------------GEEEER-QHRRK-------------------SREPEKFLD
QEQRQE----RQEQR---------------------E---L-------------------
--------------------------------------QRQQEDQQQW-QRREQRDSQE-
------------------------------------------------------------
-------------EEQL--------QRRGSQ---------------------GLKRERL-
------------------------------------------------------------
------------------------------------------------------------
--------------EEEQQLQRQ-------------------------------------
-------------------------------------RS-GR--EELRSEQERREQ--QE
RRE---------------------------------------------------------
-----------------------------------------------------------L
Q-----------------------------------------------------------
------------------------------------------------------------
---ELR------------------------------------------------------
--------------------EL--------------------------------------
--RREYQE--R--------------SGEGLRC--EQ------------------------
--------------------------QERCV-E-RLQ-ERQK-QELRR----EQQE----
------------------TP---EHE---------------EA-----DER--SESRTQR
WQLESA-------------------------------ADARQSK---VYSR---------
PRR-QEQQ-----RHYQEQEEERR------------------------------------
-------------------WRQD---R----------E---------QR---L-------
----------SQKEQELLQEEEEQRRDFKWQWQAEE-----ESKRRHQKLS---------
-----AKQPPLQEQRNRQLRAERH----------QEPDRRFREEEQLRQERDE--E----
-----------QRLGRQERDRRSREGEQLRQERDEEQRLGRQERDRRFREEEQLRQER--
-EEQRLGR---QERDRKFQ-------EE------AQIRQVRDEQL----L-----RRQEL
--DGKYEEEQLRQERDE-EQRLGRQERDRKFREE-EQL-RQEREE---------------
---------------------------QRL------------------------------
-------------GR-QERDRKFREEEQLRQ-------------------------E---
-------------RDEQRLGRQERDRRFREEEQLRQERDEE-----Q---------RLGR
-QERDRKFREEEQLRQERE-EQRLGR----------------------------------
-------QERDRKFREEEQLRQERDE----------------------------EQR-LG
RQERDRKFREEEQLRQER-------------EEQR---LGRQERDRR-------------
------------------------------------------------------------
------------------FREEEQL---RQERD--------E------------------
------------------------------------EQRLGRQERDRKFREEEQLR----
--Q-------------------------------EREEQL---L--------RRQERDRK
F-----------------------------REEEQLRQEREEQRLGRQ--ERDRKF----
QE-------------------EA-QIRQVRD-EQLLRRQE---LDGKYEEEQ-----LRQ
ERDEQRLGRQERDRRFREEEQ----LRQEREEQRLGRQERDRKFREEEQLRQE-RDEQRL
GRQERDRRFREEEQLRQE-----------------------RDEQRLGRQERDRKFREEE
QLRQER--------------DE---------EQRL--------GRQERDRKFREEEQLRQ
ERE------------------EQRLGRQERDRKFREEEQLRQERD-----EEQL------
----------RRQERDRRFREEEQLRQERDEQR---------------------------
-------------LGRQERDRRFREEEQLRQERDEQRLGRQERDRKFQEEE-QIRQVRDE
QLLRRQEPDRKFREEEQLRQEREEQRLGRQ------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------ERDRRFREE
EQLRQERDE-QRLGR-----QERF-------R-----------------KFQEEEQIRQV
RDEQLLRRQERDRKFREEEQLRQEREEQRLGRQERDRKFREEEQLRQERDEEQRLGRQER
DRKFREEEQLGQERDEEQRLGRQERDRRSREEEQLRQER------------DEEQRLGRQ
ERDRKFREEEQLRQERDEEQRLGRQERDRKFREEEQLRQERDEQRLGR------------
------------------------QERDRKFQEEAQIRQVRDEQLLRRQEGDRKVLEEEQ
LRQEREEQRLGRQERDRRFREEEQLRQER--EEQRLGRQERDRKFQEEAQ-IRQ------
VRDEQLLRRQERDRKFREEEQLRQERE-----------EQRLGRQERDRRSREGEQLRQE
--RDEE--------QRLGRQER------DRRSREGEQLRQERDEEQLRRQERDR------
--RFREEEQLRQERDEEQ-RLGRQERDR-RFREEEQLRQEREE-------QRLGRQEG-D
RRFREEEQLRQEREEQV-RHQ---EQSAFSWEEQLRRA----EQEEEQRGQRQRDRKFLE
EEQSLQQEGEEKKRRVQEQDRKFSQQEKLLQREEREELKRRLE-----RDQQYSAEE---
-----------QFAGEKRRR-QEKGLR----------------QEE-QRLLEREEQRRRQ
ERDLQQ----S------RDQ--------VWEEDKGRRQVLE-----PGKGQFASAPV---
-------------------RSSPLYEYIQEQRSQYRP-----------------------
------------------------------------------------------------
------------------------------------------------------------
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-------------

----------------MTNLLRSVVTVIDTFYKYTKQDGE-CGTLSKDELKELLEKEFRP
ILKNPDD-----------PDTVDIIMHMLDRDHDRRLDFT-----------E-FLL-M--
-V---------------F-K-L-A-M-A-C-NKV----LSK---E-YCK---A-------
SGSKKRRRSHR----------HREEESETEGE--------EE-------DTSG-----QN
SGYR---YSEG-EEHGYS---SGGSRGTPKHRHGS-----------------------G-
-SRRLRRQG------------------------GLSSSENQKGSE-KRRHESSS------
---------------------------GYSWS--------N--GKERHGSSS-GELEGKR
N--------------------------KSHV-------------SPSR----VS-----G
DEYKSG-------------------CGR--------------------------------
-----------------------------------------------WR-----------
------------------------------------------------------------
------------------------------------------------------------
-------------------GHGGRFGEQGNQSSYT-QSGYQSGSS-GEGHRCISGGWASG
YGQ-----HEPSSGS-QSTRQKGYGS----------------------RTCGQ--PQNC-
GGQQGKG--SCQSSCCGQY-----------------------------------------
-----------------------------------------------G-------S----
-GVSQSSTYSQH-----------GSGSC-GYSSNSHQKRCSSNETS--------------
---KC--------G--QHRSSSGQY------S----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------GFGQHG-----------SGSGQYSGFGHC-----------
------------------------------------------------------------
--------------------------G----------C------SSGQSSGFG-------
----------HH-ES-------TSG-----------------------------------
-----------------------QA-C-----Y---------GQHGSGS-----------
------------------------------------------------------------
-CQYSGEGQ--YG---------------------S-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------GSAQSSGFGHQKS-IS-G-QST-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------C-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------GQHGSGSGQSSGFGQAGS-SSG-QSS-GF---E
HH-EC-RS-QQ-SGY-G-HHEL-GS-GQ-SS----------GFG-QHGS-----------
-------------------------SSSQSSGFGQHRSGSCQSSS--------DS-----
----------ERHSEGSQR-----HS----RSAQGQAGSQHGES-GAT------------
------------------------------------------------------------
-------------------------V----------------------------------
--------------RGRHGTA---------HGHSED------------------------
------------------------------------------------------------
-----TIR------HG--------------------------------------------
---------------------------------------------------H-------S
S------QGHS-AQT---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---GS-S-----------QV-GGRQFSHSEAS----------DSERHS-EVSE-RH----
SGSTHGQAGSQ-HG--ESGATVR-GR-------------HRT---AHGESGDTTRYG-QS
SQGQST---RSGSSQTGRGASSHSEASDSE------------------------------
-----RHSEVSERHSG------------------------------------STHGQAGS
PHGESGAT-------------------------VRGRHRTAHG----------QSGD---
-------------------TTRHGHSSQGQSTR---------SGSSQ----------AGR
RG-SS------------------------------------------------------H
SEASDSERHSEVSERHSGSTHGQAGSQHGESGATVR------------GRHRTAHGQS--
--EDTIRH------GHSSQGH-----SAQTGSSQGQSTRSGSSQAGRRG-SSHSEASDSE
RHSEVSE----RHSGSTHGQAGSQHGESGAT-----------------------------
------------------VRGRHGTAHGES-----------------------GDTTRYG
QSSQGQSTRSGSSQTGRRGSSHSEASDSERHSEVSER---------HSGS--THGQAGSP
HGESGATV----------------------------------------------------
-----------------------RGRQRTAHGQSGDTTRHGHSSQGQSTRSGSSQTG---
-----------RRGSSH------------------------------------------S
ESGDTTRHGHSSQGQSTRSGSS--QTGRRGSSHSEA-SDSERHSEVSERHS--GSTHGQA
GSQHGESGA--TVRGRHRTAHGESGDTTRY----GQS---SQGQSTRSGSSQTGRRG-SS
HSEASDSERHS-----------------------------------------EVSERHSG
STHGQAGSPHGESGATVRGRQRTAHGQSGDTTRHG---------------------HSSQ
GQSTRSGSSQAGRRGSSHSEASDSERHSEVSERHS--GSTHGQAGSQHGESGATVRGRQR
TAHGQS-------------------------------------------------GDTTR
IGHSS---------------QGQSTRSGSSQTGRRGSSHSEASDSERHSEVSERHSGSTH
GQAGSQHGESGATVRGRHGTAHGESG---------DT-TRYGQS------------RRRG
SSHSEASDRERHSEVSERHSG-----S-THGQAGSQHGESGATVRGSHRTVHGQSGDTSG
HVHS----GQGQSTWSNKQSSHTHAHFGKRHSTSQISGRQRHRSDQAWRHGSYGSAEYDY
GQSGYGPSGGSRTSSRNSSPFRQSKGKGSHESASGKWKKISC-THAGDNSTHSESQQETH
SESVNRRSRNTGQRQGS-HHEQSRDSSRDSGTRHGQTSAE----SGNGRHRESSVSQASD
SVGHARDSGRH-------------------------------------------------
---------------------------------SETTHGRPGSSSRNQHGSSHGQTGDSY
RHSETNQGSHNERHAR--------------------------------------------
----------------------------------------------------DSGRHSET
THGRPGSTTRNQHGSSHGHTGDSSRHSESHQGQTS-------------------------
----------------------TGSRSSRHSESSVSQASDNEGH--ARDSGRHSETT---
-----HGRSG--------------------------------SSS--RKADSRNQHGFSH
GQTGNSSRHSESHQGRHSDSL------QGRSGSSTGQRQGSHHEQSRDS-SRQSGTRHGQ
TSTASRSSRHSEPSVSQASDSEGHS-----------------------------------
EDSGSRSVTTHGRSG---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------SASRNQHGSVHGQTGDSSRHSESHQGRHSD---------------------
------------------------------------------------------------
---------------------------------------TVHQRSGSSTGQRQGSHHEQS
RDSSRQSGTGH---------------GQTS-TGSRSSRHRESSVSQASDSEGHSEDSGRQ
S-----------------------------------------------------------
--------------------------------------------------------VTTH
GRSGSSSRNQHGSSHDQTGDSSRYSESHQGRHSDSL-----QRRSGSSTG----QR---Q
GSHHE-QSSDS-------SRHSGTQHGQ--------------------------------
-----TSTVSRSSRHRQSSVSKASDSEGHSE-DSGRRSV-------T-------------
----------------------THGRPGSASRNQHGSVHGQTGDSSRHSESHQGRHSDTV
HQRSQ------QGQTSSGSGSSRHSE----SSVSQ-------------------------
-----------------------------------------ASDSEGHARD---------
-----------------SGR--HSETT-------HGRSG----SSSSNQHGSVHGQTGDS
SRHSQFHQ-------------------GSHGESIHQRIQNHGAGQVWR---HGSYGSSS-
-------------------------------YDYGQLGTGSPEVHSPSHGLRGSHR---K
HVSSYD----QRRSGSRRPSSSIQHGSGS-----G-QSSGYGQHRSSSG-Q---------
-------SS-GFSHHGTGIGQSS-------------SYEQ---H-----------SSTSR
QSPNCSQHGPSL-----------SHSTSCGQYGSGSGQSSSCSQQSSGSSQSLNHGQHRS
ESSQTSSYGQQRTGSGQSSGCRQHRSGSGESSGFNQHRTGLGQSS-----------SYEQ
HGSTSGQSQSCGQHRSSL------------------------------------GQSSSY
GQHGSSQ--YSGHSQHRSGSCQSSGHS---QHGSGSGQS-----------S--------S
CG----------------------------------------------------------
-----------------------------------------------------QHGSRSR
ESSGFGQHGSGLGQSSSYGQHGSTSGQSSGYGQQGSNLGQSSSYGQRGSSQYGSR-----
------------------------------------------------------------
-----------------------------------------------QSY----------
------------------------------------------------------------
---------------------------------------------------------SHS
QHRSGSRQS-SGHSRHGSGSGQSSSYGQHGSTSGQSS----SCSQQGSNLGQSSSYGQWG
SSQYGSSQSS-R------------NSRH-RSGSS--------------------------
------------------------------------------------------------
-------------------------------------------QSSSYGQQGSSQ-----
------Y----------------G-SGQSYS----HSRHRSGS----SQ---SSGHSQHG
SGSGQSSSCGQHGSSSRESSGFGQHGSGLGQSSSYGQHSSTSGQSSGCGQQR-SNLGQ--
-----------------------SSSYGQRGSSQYGSSQ----------SYSHRRHRSGS
SQSSGHSRHGSGSGQSSSCGQHGSSSRQSSGFGQHGSGLGQSSSYGQHGS-TSGQ-----
--------SSSCSQQGSN---------------------LGQSSSYGQRGSS--------
-------QYG--------------------------------------------------
--SSQSSGCRQQ------GSGSGQSSSCGQHGSSS--RQSSGFGQHGSG-LGQSSSYGQH
GSTSGQSSSC-----------------------------------------------SQQ
GSNLGHSSSYGQRGSSQYGSSQSSGCRQQGSGSGQSSSCG----QHGSSSR---------
---------------------QSSGF-------GQHGCGL------------GQSSTYGH
HGS----------TS---GQS------SSCGQHIS-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------GSSRQQSQGCSQGQTESGYSYSNCNEGQPGGSYRQELRS-ST
PLYEYVQQQRC-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
-------------

----------------MPQLLNSILNVSKAFQKYAEHHGA-CTSLSKMELKQLLLTEFGD
ILRRPND-----------PETVETILEHLDRDRNGYVDFH-----------E-YLL-L--
-V---------------F-E-L-A-Q-A-C-HHK----LDS---K-LYG---S-------
RTSPRKEQDQK-G-----TQSHKFSEN-TGR---QH----RQ------------------
-NSHNN-KD--------------------SHC----------------------------
--------------SHSERHDTDS------HHDRD---SHHGQSERFHGDSHYGHSERED
TDYSSDQSE------------TDDQYSSSGQRLSY-------------KSNN--DQAKSQ
G--YV-------F-------------ALNQSK------NP------AQ-----------V
SHYGQS-----------------KTFGQQS------------SHGQ-SGRLR--------
--------QDSYSSQTS----------Q-----QESGSYEQY-GKQHQ-KSGYSQTDRQA
QNSHNSQPDKQRHSFQHDQTD---------------------------------------
-----------------GQSHSFHYGQMDKQGQSSHD-QKNSKGQSFHY---GQKGKQGQ
SSYQGQSDNED---QSSSWHRTDRQG-Q--S------F-----------HFDQTG-----
-------------------------S------------------------------Q---
---G-----Q-SS-YQ-G-QS-DN-ED-QS-SS-WH-RT-D-RQ-GQS-FH-Y-DQ-TG-
SQ-GQ-S-SY-QG-QK-GEQ------------GL-TS-HW-------------GQ-KGG-
QG-QTS-HQG-Q-----------KG-GQGQTSY-QG---QK-GG-QGQTSH-QG-QK-GG
QGQTS-HQ-GQ-TGGQ-GQT-SHQ-GQKG-GQG-------Q-TSHQ-GQ---K----GGQ
G-QTSH-QGQKGGQ-GQ-TSY--------QG-QKG-GQGQ-TSY-QGQ-KGGQ-GQS-SH
W-GQK-GGQGQT-SHQ-GQK-GGQ-GQTS-HQG-QTGG-QGQ-SS-HWG-QK-GQ-TSH-
QGQ---------------------------------------------------------
------------------------------------------------------------
-------------------TG-GQG-QT-SHW-GQ-TGSQ--------------------
----------GQ-TSY-QGQ--KGG-KGQ-T-------S-YQ-GQ-KG-G-QGQT-SHQ-
GQTG-GQG-QTS-HWG--QK-----------------------------GG-QG-QTS-H
WG---QKG-GQ-GQ-S---SHWGQ------------KDGQGQSSHQGQPDSEDQNSQWHR
TDR-EDHSFHFDQT----------------------------------------------
--------------GSQGQSSYQG-----------------QSDNEDQSSSWHRTDRQGQ
SFHY--DQTGRQGQSSHQGQSDNEDQSSSWHRTDRQGQSFHYDQ----------------
--------------TGRQSQSPHCGQLEIGKTELQGQNRYFQGTDE-TR-----------
--R-DSYVEQSGRSGKLSQQTSREEVN-QTQRQRFQDRRDQQTHHQAWKP----EQDN--
-------------QHKLLAQI--QQEKP--YSHNEYDWQSQSS-----------------
-------------------EEGH-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------WV-------EEEHHQ-----------------SWDRHSLEDQESLYEMQNRQT
HEDEKSHQTRDRQTHVDEKKQQ--------------------------------------
--RQHRQTHEESQDH---------------------------QHGRQTHEDEQSHQRQDK
HQ----------------------------------------------------------
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---------------------------------N--------------------------
---HHQQWDEQTHEENERFQGSQDQ-----------------------------------
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-------------------------------SRSFPNKEKFHMNED--------------
----------------------DQCQGS---------QDRHFH------------PTHGG
ERSQRREQHRNHPTKTA-NSPNPLYDYVREQAAYQY------------------------
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-------------

----------------MPQLLRDINGIIEAFRRYARTEGD-CMALTRGELKSLLEQEFAD
VIVKPHD-----------PATVDEVLRLLDEDHTGTVEFK-----------E-FLV-L--
-V---------------F-K-V-A-Q-A-C-FKT----LSESP-EGACG---S-----QE
SVSL-----RP-G----ASRELGE-GQRSGTEV--GRAGKGRPSEG--------------
-------SS-------------------------------------------------QG
QSEQA-----------SRGQNR---------------PGAQTQA----------------
------------------------QATGSVWVSSHDR------------------QVESQ
SQERT-SPQTQLRGHTEQTRAAGEGQSLQTRE------M--------------R-----P
ERQP-----QTRERDRARQTGEAV-TGSG-------------------------------
--------------------------------------------TQTQA--GTTQTLDQD
SSHQTGGTSTQTRESTSGQNRGT----------------E--------------------
-----THGQGRSQSSQ-----AVTGGHAQTX-------------XXXXX-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---XXXXXXXXXXXSH----------------QTGGTSTQTQESTSGQNRGTETHGQGRS
Q---------------SSQAVT---GG--HA----------QTQAGSHTQTV--------
-----------------------------------------E------------------
------------------------------------------------------------
----------------------QDRSQTVSHGGTRE------------------------
---------------------------------------------------QGQTQ----
TASGSGQRWTPVRKPEA-GE----------------------------------------
---------TALG-------------------------GQAQTGASTASGRQDPSSP---
-GA----------TEGRG-----------------------DRRPA--------------
-------VVVEEWVDDPSRER---AMLRLDHGS----LHT--------------------
------------------SASSAQGRDAAQ------------PE-EKQGIT-ARE-----
----------L--------------------------YSYLRSNQP--------------
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-------------

----------------MPQLLRNIHGIIEAFQHYARTQGS-CTVLTRGELKRFLEHEFAD
IIVKPQD-----------PATVDEVLRLLDEDDTGTVEFK-----------E-FLV-L--
-V---------------F-K-V-A-Q-A-C-FKT----LSESP-TGDCG---S-----QE
SGSL-----PT-G----ASQELGK-EQSRRAEV--GQAREAQPRES--------------
-------SQ-------------------------------------------------YG
QSTQA-----------SRGQAG---------------AEVQT------------------
--------------------------RG------QDR------------------QSESQ
KQERE-SQQTEAGKRVQQTERLGEDKSHQIRQ------R--------------R-----S
ETQS-----QTREQDRAQHTSGPV-TGAG-------------------------------
--------------------------------------------TRTQTLGGATQAMEQD
RSHQIRSPSTQSQESTHGQTRGT----------------E--------------------
-----VQGQDRSQTSQ-----VVT-E----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---HVQTLG---------------------------------------------------
------------------------------------------------------------
----GATQAMEQDRSH----------------QIRSPSTQSQESTHDQTRGTGVQGQDRS
Q---------------TSQMVT---GG--HI----------QTKAGPQTQRH--------
-AQAT------------------------------------D------------------
------------------------------------------------------------
----------------------QDRSQTARHVVDRD------------------------
---------------------------------------------------EGQTQ----
RQSGSSHRWTQVSHYEA-GE----------------------------------------
---------GKLG-------------------------EQAQSVASTLTGRQDWSSTHPR
CSV----------TGGQG-----------------------EREPI--------------
-------VITQEWVGDHTREM---EIPRQDQGS----LCT--------------------
------------------GIPTAQGQEAAQ------------SE-GKRSLT-AKG-----
----------L--------------------------YSYFKSNKP--------------
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-------------

----------------MAQLLNSILTVIKVFQKYGSENGD-CTSLCKKELKQLLLVEFGD
ILRRPND-----------PETVETIMSLLDRDRDGHVDFP-----------E-Y-L-L-L
-V---------------F-Q-L-A-Q-A-C-Y--H-K-L-D-N-E-SC--G-D------R
T-SQQ-E-Q-G------------------QEE----------------------------
-----------------------------------------------------------T
RDHKFPRNTG-----RQYR---ES----HEE--DR-QDSHHDQSERED-RDTHHAQ----
--------------IQQ---------ERPL-C------------------YQGRDWQSSR
C--E---------------QGHKQAQTGQSCG--------EGQSHQEGRRQSHQSQGRPR
HEGQDS----PREARDRQIPR-EQSC-QIRDRQTHGD---EQNHHRQDRQTHRD------
-------------ELDHQ-----------QQDKQTHGDELSHHRQDRWTHKEELDHQRQD
-----------------------------RWTHG--------------------------
--------------DKL--------NHHR-----------------------QDRQTHGE
DQSCQQQ--QDR---------------------QTHVEEER-----YQ---GSQDRQ---
------------------SH-----RTQQGSPNRKKLDED-----------------DQ-
-SRGSQAI------RKL---------------------KQLESN--------TEAT----
A-PAKVLRQK---HVRCAE-------RLEKRQCLRRENWLNGPQEKKKHS---AKE--AQ
NREKKEKKYVAP-----------ERKDY--------INTKEETEMQRKT----KQQQKKK
QKKSE--------S--RRIAS-SIH------V-ECRR-----------------------
-------QEDQ-RRFE---------------PRDRQMEEEPEQ-----------------
-------------------------RRRQKWQEQERELAK--------------EDGETR
EQLRDAEQRLQRRERK----------GREDQHGEEEEQLQRHTGLEEFLEEEEQKR----
----------------RGT--------------------RE-------QRELPSREQEQQ
RPGREQRERPEEEQLQSSELRELKR---E-RR-EEEPQ---RRREGPG------------
-----------------RQDEEELL-QGQRR-G-RRE-PRYD-QGRRR----EQELA---
---------------A---E---PQE---------------QA-----REQEKGRTPRWR
WQLESE-------------------------------VDAHQSK---VYSR---------
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-Q---------RRRYVPTA-------ET------AQREQLNEEEQ----L-----QREE-
-------------------QQLHGQKRYRQYREE-EEL-QQEEEQLQRER----------
------RRQERDRQYRGEEAL-QQEEEQLQR-----------------------------
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LQR---------ER-----RRQERDRQYRGEEALQQEEEQLQR-----------------
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---ERRRQERDRQYRGEEALQQEEEQLQRE----------------------------RR
RQERDRQYRGEEALQQEEEQLQRE--------------RRRQERDRQ-------------
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F--------------------------------------------R--------------
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---------------------------------------------------QRDRELREE
EQLLLDDREEAQL-----------------------------------------------
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-----------------------RQERDRKFRK---------------------------
------------------------------------------------------------
------EEQLRPWEHDRKFQEEEQLLQER--EEQQLRRREREQRLRQERD--------VE
FREDEQLRRQERESKLRDDERQLRQER---------------------------------
----------------------------------------------------YA------
--QLRQ-----------EEQARHRDRD-RQFREDELLR-QELG-------EQQSRQEV-N
RKFREERQLREE-----QQLRRQELQVAFSREEQLSRA----EPEEELSRRRQRDRKFLK
EEQILEQAREEERGRRGEQDGNLREEA-------REEQRRQQE-----RYRLYPAEE---
-----------QFVRETRL---LQEQLRQEEQTRRQERERKFREEEQLLHQDQEEQRRRQ
VRE---------------RE--------TREAAQGRRQVLE-----PSTRQFAHTPV---
-------------------RSSPLYEYIQEQSSQYHS-----------------------
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-------------

----------------MPQLLRNINGIIEAFGRYARTEGG-CTVLTRGELKKLLEHEFAN
VIVKPHD-----------PATVDEVLRLLDEDHTGTVDFK-----------E-FLV-L--
-V---------------F-K-V-A-Q-A-C-FKT----LSEGP-GGACR---S-----QA
PGSY-----YS-G----SSKELQE-SQRISTEV--GRDERQQPHQG--------------
-------SS-------------------------------------------------HE
QIEQA-----------SRRQTR---------------PDTQYQGR---------------
-------------------------------DRSQDR------------------KAEFQ
RQERV-SQQTQVTGHVEQSRRTGDDKRHQDRE------G--------------R-----T
ERQS-----RFGEQTNET-----T-ATTA-------------------------------
--------------------------------------------I---------------
-QTQRGRTNIQTQESIYGQTRGN----------------E--------------------
-----THGQNRSQTSQ-----AVAGGHSQSQ-------------AGPQTQTHTQTIEQR-
--QTGNSGIQTQ---ESINCQTSGTE-----------------------------THGQD
WSQ---------------TSQVVTGG----------------------------------
-------HIPTQTGSQIQTHTQI--------------TEQDRGC--------------QT
GNTNNQTQGFTCGQARGTET----------------------------HGRDWSQTSQVV
TGGHLPTQSGSYT-----------------------------------------------
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---WTHTQTAEQSRNH----------------QSGSTGIQTQASTCSQTRGTESHDTEFS
R-----------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------G-PG------------------------GQAQT----GTRRQDWNSTRV-
-SG----------TGRQD-----------------------EGDT---------------
-------EFSGEWVDDHTREI---VIRSQDQGR----GHS--------------------
------------------EHPSGL----AY------------SE-VKGNIT-IKG-----
----------L--------------------------YSSFKSSKP--------------
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-------------

----------------MSRLLRGVFCVVEIFHKYAIEDGDNQATLTRTELRQLLEGEIGD
FLQPHV------------FHAVERKLNLLDFDRDGTISFE-----------E-FVL-A--
-I---------------F-S-L-L-N-P-S-YFD----I-S-----LLN---S-EPRL--
-MSKS-EK--TDA------VDLGTIV---GN---------IQQVVG---VGPT-------
-----------QERV----------------IVPS----------------------EMA
SSGQPSNEEG----------------EVGDEPMVS-PCEDINTHSLPRNVSEPNDP----
---ENQQP-------------------------------------------------KED
---------AQEVAQNVPATEYDGVQ-FKRNT---AVAVPKQSTSPTQ--------EIPR
ERS-KP----SRRLSDT------KISDHV-------------------------------
-----------------------------------------------------KQRPTE-
-----------------DE------------------EHT-----------STTQDPFL-
------Q------------------KRDKAA-------------GAENT---DLS-----
VVAATRKSSQTQ---EIFEPKDD--TKL----SEVQETGKDAG------------RIPPE
-------------TN--LEEPKADAR---------------------VAESHGLPAQE--
------------------------------------------------------------
------------------------------------------------------------
------------------REHKTRDQSVQSWSRNV----SEASSRG--------E-----
------QEGEW-KE--------------------HER---------------------IT
LSPAA-------------EAETQDEKC--QEFPGSW-------RENDAKKDTAV------
-----------------------------------------KDPSSEEGNQN-----LPE
I--------------K-------ED----S-VSGKEARHSEEDTVDAFENNKNSPAAEET
LETRE----------RSQE-----------------------------------------
--------------------------------------------LAPLEK-QSQRKKHRA
TRTQDK--PIRKEDHNE-----------------------------------GEDSELSL
TQSDEGFCETPNSLAPEVGKSSSEIA---------------E------------------
--------PHVPEDSQ------------------SQIDHHGDAK---------QESHTNN
PDP---------------------------------------------------------
------------------------------------------------------------
---------------------------------------------QKQGAPGESSREQEA
V------VLSIQ------------------------------------------------
--EDGQLPEGQEQSARDGLHDG--------LSSR-----TKGGPGAAVEPSEGEEVQ---
---EATSGS--ENRKALEAESSEAQ-----------------------------------
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-------------

----------------MPQLLQDVIYIIETFQKYAREEGD-CWTLSLDQLKQLLTEEIEE
F-LKPLD-----------TLTTGTNLNLLDRDGNETISFN-----------E-FIL-L--
-V---------------F-G-L-L-N-I-C-YQD----IRS---F-LNP-EPKAESDTEQ
ELSGDVEVCETN-------ELYQEEAELGQYEQ---RLT--GTE------SPS-------
-------LVNP-I--------E------------------------------------KV
SDILTKEDPQDE---TPRLLGREVEKIHAKSQS-----QGEGEKQSP-------------
---E-----------------------KT-EVQATGDDQIPPEEKRPQK-----------
E--FV----------------------KTACS---QKEEDC-KEGPEV----------PR
EQSGKDTRDQPSQQKGE-------------------------------------------
----------------------------------------QNMEIQ---SVHTE---EKA
Q---RR----------------------SESQEGA-IIKE-------------AGEHTE-
-----TREPSS-QEVHE--------RESETV---------------------DLS--TER
AEEKLSE---TK---RLPEYRDDH--GT----PDIQELLV--------------------
---------K-IKCEIQDIS--AKGDD--------------------SRVP---------
---------------------EI-----EVLVDERKGKRK------PE------------
-------KSETVGQKGNEE---------NNQIEILTEQEPDR-----------KEK----
---QLE---GRE-----------EEVDI--------RKDSVTPELKSGDDQN-HLEHKGS
ATSEE--------E----HPE-ISE------P-EFS---------------------EDN
R--------------S-----------------ASVVERTPETKDRIHG--------SEP
QDNQYGGKN-GR----NTQTVD---QPTEQYDGHKVKNENDGTLSEIYDNPGDGESGS-E
SR------DL---------------------PTQRNCQRQV--DS-----Q---------
-------------EQHDQE-----------------------------------------
-----------------------------------DSKNP----QDPQLSD--------K
SRTPETEVPIDREHNENTTEELEKLTKEKRN-----SVAKTP-----ATTQES-------
-------------------E---SQS---------------EAQESMKQNLTATCP---K
TKITDPTD----------------D------------DGGQLST---VQQS---------
E------------------KEDQR----KDPE-------VHGRS--------E-------
-------------EGEASESQES---P----------L-------EGRDPNTI-------
--------------S--PWI-----QPDTLNLVTRE-----DK--SPQNLA-EVSEQQYV
VNKESDSLPGLSEQIERNPRD-----------A------DPCS-----------------
------------------------------------------------------------
---SSGDEV--HSNPIH----ENLQTTP------AQPDFTAPKEH----L-----SQTDT
----------TH--TDGPDLRVEREPQKTKTS-ECPAL----LNPLCGYG--QEL-----
--SSR---KP--------------------------------------------------
-----------------------PEEKYGSQ-----------------------------
----------------------QEALATQP------QEDQ---PQ-----Q-EDQKQ--Q
RDGSPKKW----------------------------------------------------
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-------------

----------------MSTLLENIFAIINLFKQYSKKDKN-TDTLSKKELKELLEKEFRQ
ILKNPDD-----------PDTVDIFMDHLDIDHNKKIDFT-----------E-FLL-M--
-V---------------F-K-L-A-Q-A-Y-YES----TRK---D-NLP---I-------
SGHKHREHSHH----------HKHEDDKEEEN--------KE-------NRKR-----RP
SLERRNNR-----KGNKG--RSKSPRETGGKRHES-----------------------S-
-SEKKERKG------------------------YSPT-HREEEYG-KNHHKSSK------
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K--K-----------------------LSER-------------PEEK----ED-----K
EGGGYD-------------------YENIG------------------------------
------------------------------------------RMTEKWTESGHIDTYYTF
QDE--AY-----D----T---------TDNLLEENKIYER-----SS-------------
------------------------------------------------------------
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RTRKRRG--SSVSQ----------------------------------------------
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-----------------------DSGSE-GHSEDSQRW-SGSASRNH-------HG----
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---------------------------------------D--------------------
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-----RASHGHSA------DSSKQSG-----------THHAETFSRGQATS---------
SHE---------------------------------------------------------
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------------------------------ESAHGRS-----------------------
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QARD-------------------------------------RS--RHAA-----------
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-------------------------------SQESQDTIRGHTGSSRGGRQGY-------
HHQQS----VDSSEHSGSYHSHKTSQGR-SE----------A-------------FRRQS
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FRHSQSGQGESVGSRTSR---------------------------RQGYSVSQD------
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RQSGTHY-----------AE-------------------TSSRGQAVSSQEQARSSP---
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AS-------HSEGHSEDSDTQSVSAHGQAGPHQQSHKE----------------------
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HNTSQGRSDASRGQSGSRSASRQTRNEEQSGHGSRHSGSRHHEVYTQAK------SSRHS
QSGQG--ESVGSKTSRWQGSSVSQDSDSEGHSEDSER---------WSES----------
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HHA---------------------------------------------------------
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----------------------------------------------------ETSSHGQA
VSSQEQARSSP--GERHRSHHQQSADSSRH----SGT---GRRQAS-SAVRDSGHPG-SS
GNQASDSEGHSEDSDTQSV------SAHEQAGPHQQSHQESARGRSGERSGRSGSFPYQV
STHEQSESAHGRTGPSTGGRQGSRHEQARDSSRHAASQEGQDT-----------------
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-------------

----------------MPHLLRNIKGIIEVFGRYTRTEGD-CTALTRGELKRLLEHEFAD
VLVNPHD-----------PATVDEVLRLLDEDDSEMVEFK-----------E-YLV-L--
-V---------------F-K-V-A-Q-A-C-FKT----LSESP-EGVCG---S-----QE
SRSG-----HT-G----ASQDLE--GQRSHTKV--GRAGKEQERRG--------------
-------QR-------------------------------------------------PG
NGTVL-----------TRQTGA--------TQ-----TLGQGRSH---------------
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GQ-----------GRSQASQVATEE-H---VQ------T--------------Q-----P
GSQS-----QTVEDNRSQ-PNQEV-TGGH-------------------------------
--------------------------------------------VQTQA-GSNAQTVEQD
R-------STQPWEPTSGQTRGT----------------E--------------------
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SQSSQDRSTQPW---KPTCGHTRGTE-----------------------------TQGQG
RGH---------------ISQMVTGG----------------------------------
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RSTKPW---GSTCGQRGTET----------------------------QGQGRSQTSQVL
TGGHVQAGSQ--------------------------------------------------
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--SQMHSQTMEQDRGH----------------QAGS--TQPWESTCGQTRETETQGQGRS
Q---------------TSQVAT---GG--HV----------QTQGTSQNQMH--------
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----------------------QDRSQMASHTGTRE------------------------
---------------------------------------------------QGQAQ----
TQSGSGQRWTQVSNYEA-GE----------------------------------------
---------SVLG-------------------------GQDQTGASTLT---------KR
CNV----------TGGQG-----------------------ERGLH-P------------
---REATVVGQEWVDDHTGET---VTHRQDQDS----WHP--------------------
------------------SAPSAQGQDTAQ------------PE-GKQGIT-APG-----
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-------------

----------------MPYLLNSICTISGVFYKYAKRHGD-SSILTKREMKRLILEEFAD
VIENPRD-----------RKTVELTFQMLDTNGDGLVDFN-----------E-YLL-L--
-I---------------L-K-V-A-E-A-C-YSH----LKP---S-EDL-LEKTERSTAE
-CGGEQRRNNRNQVEDNRYHPPTEGTERGQE-----------------------------
---------------------R------------------------------------RN
YHPLEPEAPVDER-SHQDLERRD-HRGRDRPSHEP---QEDEDGQ-IYWY----------
----------------GQQ------QKTEEWYHQIRQRDPL-------------------
------------A--------------EDNCP---RRSQDLLSRRQH--DERQHQEHDPL
GEYDSL----PREDKRT-------------------------------------------
-----------------------------------------RLNGSEWEQRRNETHEREP
R---AR----------PS---------DPEWRGGR-RADG-------------QGEPEL-
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TQSCQSIRREEA---EDHQWSESREREQSRSHSHEPEPVESER--------RPL------
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DAKES--------D--RRKSQ-QHD------R-SYER--------------------ERS
QL-------------T-----------------EPQTRHSDQDRSCASD--------GSP
RDHYQKRQQ-SD----R-PTIT---QQR---------N---------SDQRNHEANR---
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-------------

----------------MSPLLRSICDITEIFNQYVSHDCD-GAALTKKDLKNLLEREFGA
VLRRPHD-----------PKTVDLILELLDRDSNGRVDFN-----------E-F-L-L-F
-I---------------F-K-V-A-Q-A-C-Y--Y-A-L-G-Q-A-TG--L-D------E
E-KRA-R-C-D-G-K-E-SL-L--QD-RRQEED-Q-R-----------------------
-------------------------------RF-------------------------EP
RDRQLEEEPG-----QRRRQKRQE----QER--EL-AEG-EEQSEKQE-RLERRDR----
--------------QRR---------DEELWR------------------K-RREWQEQE
E--R----------------RAEEEQ-LQSCK-------------------GHETEEFPD
EE-QLR----RRELL---------------------E---LRRKGREEKQQQRR------
-------------E------------------R--QDRVFQEEEEKEW-RKRETVLRKEE
---------------------------------EK-LQEE-------------E--PQR-
-----QRELQE-EEEQL--------RKLERQ---------------------ELKRERQE
LKREQEQ--QQQ---RLRREQQLRRKQE-EE-RREQQEERR-----EQ---Q--------
----------------------------------------------------LRREQEE-
-ERI--------------------------------------------------------
------------------------------EQQLRREQ------EEERHEQERREQ--RL
KRE-------QE-----------ERRDW--------LKREEETERHELE----TRKQQLK
REQEE--------E--RR----ERW------L-KLEQRLGRE------------------
------------------------------------------------------------
------------------------------------------------------------
--------QQLRREQE--------ERREQLLKREEEERLEQEERREQRLKREQEERR---
-EEEE---------ERRQQ-RLKREQEERLEQRLKREEV----------ERLEQEERREQ
RLKREEPEEERRQQLLKSEEQ-EERRQRQLRR--EQRLKR-EEE----------------
--------------------EERLEQEEERL-E-QRL-KREH-EEERR----EQEL----
---------------A--EE---EQE---------------QA-----RERIKSRIPKWQ
WQLESE-------------------------------ADARQSK---VYSR---------
PRK-QEGQ-----RRRQEQEEKRR------------------------------------
-------------------RREN---E----------L---------QW---Q-------
----------EEERAHRQQQEEEQRRDFTWQWQAEE-----KSERGRQRLS---------
-----A-RPPLREQRERQLRAEER----------QQREQRFLPEEEEKEQRRR--QRRE-
REKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQ--LEEER--
-K---------RRRHTLYA-------KP------ALREQLRKEQQ----L-----LQEE-
---------ELQ--REE-REKRRRQEQERQYREE-EQL-QQEEEQLLREE----------
-REKRR-RQERERQYREDEKL-QQEEEQLLG--------------EE-------------
---------PEKRRR-QEREKKYREEEELQQ-------------------------EEEQ
LLR---------EE-REKRRRQEWERQYRKKDELQQEEEQLLREERE---------KRRR
-QERERQYREEEELQQEEE--QLLREEREKRRR---------------------------
------------------------------------------------------------
-----------------------------------------QELERQ-------------
------------------------------------------------------------
------------------YREEEEL---QQEEEQL---LREE------------------
------------------------------------PEKRRRQELERQYREEEELQ----
--Q-------------------------------EEERLL---RE--EQEKTRRQERERQ
Y-----------------------------WEEEELQRQERKQRYRDEDQRSDLKR----
QWEPEKENAVRDNKIYCKRRENE-QFRQLED-SQVRDRQSQQDLQHLLGEQQ------ER
DREQERRRWQQRDRHFPEEEQ----LERE--EQKE-AKRRDRKSQEEKQLLRE-EREEKR
RRQETDRKFREEEQLLQE-----------------------REEQQLRRQERDRKFLEEE
LR---------RQEQGRKFLEE---------EQRLRRQ----------------------
----------------------------ERERKFLKEEQPLRRQE-----REQQ------
----------LRQDRDRKFRE---------------------------------------
-EEQ--------QLSRQERDRKFREEE--------QQVRRQEGERKFLE----------E
EQQLRQERDRKFREEEQLLQEREKQQLHRQ------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------ERDRKFLQE
EPQLRRQERE--------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------QQKFRE---------------------------EGQLPQ------
EGEEQQLRRQERDRKFREEEQ-------------------QLRRQERERK---------F
--LQEE--------QQLRRQEL------ERKFREEEQLRQETEQEQLRRQERYR------
--KFLEEEQLRQEREE-Q-QLRRQERDR-KFREEEQLRQEREE-------QQLRSQES-G
RKFREEEQLRQEREEQ--QLRPQQRDGKYRWEEEQLQL----EEQ---------------
------------------------------------EQRLRQE-----RDRQYRAEE---
-----------QFATQEKSRRQEQELWQEEEQKRRQERERKLREEH-IRRQQKEEQRRR-
-----Q----V------GEI--------QSQEGKGHGRLLE-----PGTHQFASVPV---
-------------------RSSPLYEYIQEQRSQYRP-----------------------
------------------------------------------------------------
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-------------

----------------MPKLLQGIVTVIDVFYQYATQHGE-YDMLNKAELKELLEREFHQ
ILKNPND-----------PDTVDIILQSLDQDHNKKVDFT-----------E-YLL-M--
-I---------------F-K-L-V-Q-A-H-NKT----IGK---D-YCQ---A-------
SGSKLSDGIHQ----------HQEEQEETEKE--------D---------DKR-----QE
SSFSHSSWSAG-ENDSYS---RNV-RE---------------------------------
------------------------------------------------------------
----------------------------------------S--IKHSTESIS-RRL----
----------------------------------------------------SF------
---QRD-------------------FSGQH------------------------------
----------------------------------------NSC-SG-------QS---S-
---SYGE----QN--------------------------S--------------SSHQT-
---------SDRGQHGSGTGQSPSYGRHGSGSGRS-------------------------
---------------------------------------------SNSGPHGSGSGQSSG
-------------FG-QHESS-----S--------------------GQSSG--YSQHG-
S-----G--SGHSSGYGQH----------------SSRSGQSSRGER-------------
--------HGSS------------------------------------------------
--SGSSSSYGQH-----------GSGS--------------------------------R
QSSGH--------D--RHGSGSGQS------P-S--------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------P-SRGRHGS-----
-------G-------SGQSSSYGPYG-----------SGSGQSSSRGPY-E---------
S---GSGHS-----------S---------------------------------------
------------------GLGQQ---E----------S------HSGQSSGYS-------
----------KQ-G----------------------------------------------
---SS--S-GH-S--------S-TH-------G---------Q-H-GST-SG--------
-------------------------------QS-S-----SC-S------Q-HG-ASS-G
QS-SSH-GQ--HG-SGSSQ-SSGYSRQGSGSGHSPS-RG-RH-GSG-SGH-SSS-YG-QH
-GSG-SV-WS-SRN-GP-HG-SG-SGQSSG-FG---QH---------ES-----------
---SS---------GH-S---------TGN-SQ-H-----GS------------------
-------------------GSG-HS-----------------------------------
------------------------SG-YGQ-------HGS-RS----------------G
-Q-SS--RGE-Q----H-G-SS-SGS-SSSY---GQH-GSG-S-----------------
-------HQ-SSGH-GQ-------------------------------------------
-----------------------------Q---GSG-S--GQS-P-S-H-----------
-------------G----QH---GSG-SGHS-SHGQ------------------------
-------PR-SG-SS-CS-SS--------------------------RG-HYE-S-----
-----------------------GSG------------------QA----------SGF-
GQH--ES--GSG-------QSS-GY-SQH-GS----S-SG---------H----SSS-QG
--RHG-ST-SGQS-SSS-GQ-HG-SSS-GQS-SH-YG-HHE-S--G-S---H-QS-----
---------------LG-RS-RHT-SG-----S-C-QSP-----GHG-QHGS-GSG-SRK
-SSS--------------------------------------------------------
-----SS---------------------------LHG-SG-------S-GQSS-GF-GQH
------------------------------------------------------------
------------------------------------ESG-SGQS-SGY-G-QH-GSG-SG
H-SSG-Y---G-QH-SS--R-S-----------GQS-S--R-----------G-E-RH-G
-S-S----------S--GSS------------------------SSY--GQHGS------
-------GSR------------QSSGHDQQGSGSG------------QSPSPSRGR----
---------------------------------------------R-GSGSRQSSSYGPH
-GSGSGW---------SSSRGPYKSGLGHSSGLGEQQSRSGQSS--------GYG-----
----------QH------------GSSSGHSSTHGQHGSTSGQS-SSCSQHGATSGQSSS
HGQHGSGSSQSSGYGRQG-SGSGHSPSRG-----------------------QH------
GSGS-GHS----------------SSYGQ---HGSGS------------------V----
----------WSSRNGPHGSG---------SGQSS-------------------------
--GFGQ-----------H------------------------------------------
---------------ES----SSGHS----------------------------------
------------------------------------------------------------
----------T-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---GYSQ-----------HGSGSGHSSGYGQ-----------------------------
-------HSSR-SG--Q-----------------------------------SSRGE-QH
--G-SSSGSSSSYGQHGSGSHQSSGHGRQG-SRSG--------QSP-SHGRHGSG--SGH
SSSHGQHGSGSSCSSS-----------R-GHYESGSGQASGFGQHESGSGQSSGYSQHGS
SSGQSSSQG--------------RHGSTSGQSSSSGQHGSSSGQSSSCGQHESGSH----
------------------QSLGRGRHGSGSGQS---------PGRGQRGSGSGQSPSYGQ
HGSG--------------------------------------------------------
---------------------------SGRSSS-SGPHGSGSGQSSGFGQHESSSGQS--
--SGYSQHES--------------------------------------------------
------------------------------------------------------------
----------GSGH--SSGYGQHSSRSGS-------------------------------
------------------------SSRGERHGSSSGSSSSYGQHGSGSHQSSSHDRQGSG
SGQSPSPSRGRHGS----------------------------------------------
-------------------------------------------GSGQSSSYGPRGSGSGQ
S-----S-----------------------------------------------------
-----------------SRGPY--ES----------------------------------
------------------------------------------------------------
------GSGHS------------------------------------------SGLGQ-E
SRSGQS-SGYSQHGSSSG--HSSTHGQHGSTSGQS-SSCGQHGASSGQSSSHGQ------
--------------------------H-----------------GSGS--SQSSGYGRQG
SGSGHSPSRS--------------------------------------------------
-----------------------------RHGSGSGHSSSYGQH----------------
------------------------------------------------------------
----------------------------GSGTSWSS-------RNGPHGSGSGQSSGF--
-GQH----------------------------------------------ESSSGQSSGY
SQHG--------------------------------------SGSGHSSS----------
----------------------------YGQHGS-SSGQSS----RGERHRSSSG-----
-------------------SSSSYG--------------QHGSG----------------
----------------SHQSSGHGQ-----------------------QGSGSGLSPSRG
R-HGSGSVHSSSHGQYGSGSNC--------------------------------------
----S-----S-------------------------------------------------
SCGHYESG----------------------------------------------------
-----------------------------------SGQASGFGQHES-GSGQSSGYSQH-
----GSSSGHSSSQGRHGSTSGQSSSSGQHGSSSGQSSRYGHHESGSHQSLGRSR-----
--------H-TSGSCQSP----------------GH------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---GQHGSGSGSRK-----------S----------------------------------
-----------S-SS-------S-------------------------------------
------------------------------------------------------------
-LHGSGSGQ--------------SSGF------------------------GQHESSSGH
ST--GYSQHGS------GSGHSSGYGQH--------------------------------
-------------GSRSGQ-SSRGEQHGSSSGSSSSY---GQHGSGSHQSSGHG------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------RQGS--GSGQSPS---HGRH---G--------------SGSGHSS
SHGQHGSSSSCSSSRGHYESGSGQSSG--FGQ---------HESSSEQSS----------
-----------------------GYSQHGS--------G-SGHSSGYGQHGSRSGQSSRG
KQHRSSSG-------------------------------------------------SSS
F-----------------------------YDQHGS-GSRQSSG----------------
----------HSQQGSGSGQSP-----------------SRGRHGS--GSGYSSSHGQH-
-GSGSSCSSSHGH-YESG------SGQS--------------------------------
------------------------------------------------------------
------------------SGYSQH-------------GSGSSHSSSQ-----------GR
HGSTSGQSSSSGQ-----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
HGSISGQSSSYSHHESGSRQSLDRGGH--GSGSGQSPGRGHHGSGSGQSPSYGRHGSGS-
-------GRS-----SSRGPYKSGSGHSSGLGQQESRSGQSSGYSQHGSSSG--------
-----------------------------R------------------------------
----STTHGQHGSTSGQSSSCGQH-GASSGQSSSHGQHGSGSSQSSGYGRQ---------
----------------------------------GSGSG---------------------
------------------------------------------------------------
--------HSPSRSRHGSGSGHSSSYGQHGSGT-----------------GWSSRNGPHG
SGSGQ-----------------SSGFGQHESSSGQSSGYSQH------------------
--GSGS-------GHS------SSY------GQHGSRSGQSSRGEQHGSSSG--------
SSSSYGQHGSGSHQSSGHGRQGSGSGQS----PSHGRHGSGSGHSSSHGQHGSGSSCSSS
RG-HYESGSGQASGFGQHESGS--GQSSGYS-----------------------------
----------QHGSSSGHSSSQGRHGSTSGQSSSSGQHGSSSGQSSSCGQHESG------
--------------------SHQSLGRGRHGSG-------------SGQSPGHGQHGSGS
GQSPSYGQHGSGSGRSSSSGPHGSGSGQSSGFGQHESSSGQSSGYSQHES-GSGHSSGYG
QHSSRSGQSSRGERHGSS---------------------SGSSSSYGQHGSGSRQSSGHD
RQGSGSGQSPSPSHGRRGSGSGQSSSYGPHGSGSGRSSSRGPYKSGSG---HSSGLGQQE
SRSGQSSGYSQH------GSSSGRSTTHGQHGSTS--GQSSSCGQHRASSGQS-SSHGQH
GSGSSQTSGYGRQGSGSGQS--PS-------------------RGRHGSSSRHSSSYGQH
GSGSVWSSSHGPYES---GSGHSSGLGQQESHSGQSSGYGS---SS--------------
--------------------GHSSTHGQHGSTSGQSSSCGQHGASSG------QSSSHGQ
YGSGSS--QSSGYGRQGSV----SGQSPSPSRHGSG--SRHSSSYGQHGSGSGRSSSRGP
YESGLGHSSVFGQHESGSGHSSAYSQHGSG----SGHFSSH--------------GQHGS
TSGQ--------------------------SSTFGQGGSSTGQSS--------SY-----
G-------------HRGS-------------------GSSQSSGYGRHGAGSGQSPSHGR
DGSDL--GQS--------------------------------------------------
--------------------------------------------------S--SYG-LHG
S-GSGQSS-GYSQHGSGSGQDGYSYC-KGGSNRE----GGSSGSNFLSFPSSTSPYEYVQ
EQRRYFYQ----------------------------------------------------
------------------------------------------------------------
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-------------

----------------MAQLLNSILSVIEVFHKYAKGNGD-CALLCKEELKQLLLAEFGD
ILQRPND-----------PETVETILNLLDQDRDGHIDFH-----------E-YLL-L--
-V---------------F-Q-L-V-Q-A-C-YRK----LDN---K-SHG---G-------
RTSQ-QERGQE-G-----AQDRKFPGN-TGR---QH----RQRHEEERQ-----------
-NSHHS-QPERQDGD---------------SH--------------------------RG
QPERQDRDS--HH-GQSDKQDRDSHHGQP---------------ERQDRDSHHNQSERQD
KDFSFDQSEKQ------------SQDSS--------SGKK---VSHK--STS--GQAKWQ
G--HI-------F-------------ALNRCE------KP------IQ-----------D
SHYGQ-------------------------------------------------------
---------------SE---------------------------RLTQ-Q----------
------------------------------------------------------------
----------------------S-----ETLGQASHFNQTNQQKSGSYC---GQSERLGQ
ELGCGQTDRQG---QSSHYGQTDRQD-Q--S------Y-----------HYDHTDRQGQS
-------------------S--HY------------------------------------
----------------SQTDRQG-------------------------------------
------------------------------------------------------------
-----------------------------------------------QSSH---------
------YGQMDRKG---QCYHYDQTDRQGQGSHY-SQPNRQGQSSHYGQ---P---D-T-
---------------------------------------QGQSSHYGQTDR---------
------QDQSSH----YGQTER--QGQSSH-----YSQMDRQGQGSHYGQTDRQGQSSH-
------------------------------------------------------------
------------------------------------------------------------
-------------------YGQPDRQGQNSHYGQTDR-----------------------
-----------Q------------------------------------------------
---------G--------------------------------------------------
-----------------------------QSSHYGQTDRQGQRSHYSQPDRQGQSSHYGK
TDR-QDHSY------------HYGQLDR--------------------------------
----------------QGQS-----------------SHYGQTDRQGQSFHYGQPDRQGQ
SSYY--GQMDRQGQSSHYGQTDRQGQSSHYGQTDRQGQSYHYGQTDRQGQSS--------
----------HYIQSQT---------G---DI--QGQNKYFQGTEG-TR-----------
--K-ASHVEQSGRSGRLSQQTPGQEGY-KNQGQGFQSRDSQQNGHQVWEP----EEDSQ-
-----------HHQHKLLAQI--QQERP--LCHKGREWQSCSS-----------------
-------------------EQGHRQAQTRQSHGE--------------------------
------------------------------------------------------------
--------------------------G---------------------------------
------------------------------------------------------------
----LSHWA------EEEQGHQ-----------------SWDRHSHESQEGPCGTQDRRT
HEDEQNHQRQDRQTHEHEQSHQ--------------------------------------
--RRDRQTHEDKQNR-Q-------------------------RRDRQTHEDEQTRQRRDR
QTHEDE-------QNH--------------------------------------------
------------QRRDTKTHEHEQSHQRR-----------D-------------------
--------------------------------RQTHEDEQNHQRRDRKTHE---------
-----------------------------------HEQSHQRRDRQTHEDKQNHQRRDRQ
THEDE-------------------------------------------------------
Q-----------------------------------------------------------
-------THQRQDRQTHEDEQNHQRRDRQTHEDEQ-------------------------
-----------------------------------------------NRQRQDRQTHEDE
QTHQRQ----------------------------DRQTHEDEQNCQRRDRQT--------
--------------------HEDEQNHQRRDRQTHEDEQNCQ------------------
-------------RRDRQTHEDEQNRQRR--------------------------DTQTH
E----------DEQNHQRRDRQTHEEDQN-------------------------------
---HQQQHNRQNYEEKERYQGSQNQKSQMT------------------------------
------------------------------------------------------------
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-------------------------------HRSCPNREKFHMKED--------------
----------------------DQSQGS-----QKRHTEPSFY------------PTQSS
GRPQSREQR-GHPAKGA-TVPNPLYDYVQEQKSYPY------------------------
------------------------------------------------------------
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-------------

-MSFVCSFSQSPELGKMSRLLRDVLCVIETFHKYAREAGD-EATLTCTELKQLIQGEFGD
VLQPHA------------ILAVERNLNLLDIHSNGTISFD-----------E-FVL-A--
-I---------------F-N-L-L-N-L-C-YLD----IQS-----LLK---S-ELRQ--
-VSEP-EK-KPSG------MDLQVTS---GT---------DQWTEQ---TAAT-------
-----------QDRV----------------APPS----------------------GMA
LSAQLSPKER----------------EHNGVDPQ----ENTKTYKLLVEASEHNDS----
---KNQHL-------------------------------------------------EKD
-------QWSQKTAQGTPATGDSGAQ-LESNK---SRAESEQIGGPTK-GKG-RDKDSPR
EGD-KP----VREQSST------KTRYQF---------------GEQEGNLR--------
--------------------------------------------TKSDLPEK-TQRPAK-
-----------------DE----------EVAAEK-GIKE----------HSKTQELSL-
------P------------------GKDD-P-------------SSEHT---GLP-----
EQEADQKSLQTE---KPVEPEDD--DRT----SENQEPGEDAG------------RTPPE
------------TKN--TVKPRDDGR---------------------TSETQEPPAQE--
------------------------------------------------------------
------------------------------------------------------------
------------------KEHEPKNLPDQGDSINV----SETPDVR--------AVRKER
RGSKAHGTAGG-KE--------------------NER---------------------KI
QLPTL-------------EDQPQDGKY--QELQVSS-------KGR--LEGSKI------
-----------------------------------------KGLSSQRGNQN-----HPE
I--------------E-------GR----V-TPE-EARHAEKFIAEALKGIKNATVAEGT
PGARE----------RTQE-----------------------------------------
--------------------------------------------LEPLKN-QSGEENKRV
TKTHDK--PVKEDDGYQ-----------------------------------GKDPEPTL
TQNNDSSPETPNSLAPEDGDSSSETT---------------D------------------
--------LPVKEDAQ------------------SQIDPLREPV---------ERSHNNN
PDP---------------------------------------------------------
------------------------------------------------------------
---------------------------------------------EKQVALGEERT-QEV
M------VP---A----------------------------V------------------
-GEDKRLPEEPEWAAREDHR-S--------QGSG-----T-KGPGPAVHPDGHPETQ---
---ESTASG--ENRKSLETEIPGTLDVG--FTDQLSIRQLPAKED---------------
-------------------SSKTLKAQSPSTKGKEGGAPETQEARVKSLDEDNSASP---
--KTQLEREE-------PTTL--KEDEIPQELAGEANDQQNPAKK-GYDASVPQSGLEEK
TQMDKEPRFVERGAVYASPLYQYLQEKILQQMDMTQA--------------------EQ-
------------------------------------------------------------
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-------------

----------------MPQLLQNINGIIEAFGRYARTEGD-CAVLNRGELKNLLEHEFAD
VIVRPHD-----------PATVDEVLRLLDEDGTGTVDFK-----------E-FLV-L--
-T---------------F-K-V-A-Q-A-C-FKT----LSESP-EGACG---S-----QA
SGSL-----HP-G----ASQEPGG-TQTAGTQV--GRLGKGQHHEE--------------
-------IG-------------------------------------------------HG
QREQA-----------SGGQGG---------------TGTQIQG----------------
------------------------QDIGSMWVSSYDR------------------QAESQ
RQERT-SQQTQAPGHRVQTQRVTESNSHQTRE------T--------------R-----S
ETQS-----QTRDQDRAHQTGGTS-HSEW-------------------------------
--------------------------------------------GRV-------------
------------------------------------------------------------
---------------------------------------------QIQAGSHTQTVEQDR
SH----------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------QK
GGTSHQTQQSTQGQNRGTET----------------------------QGQDRSQTSQGV
TGGRVQTQAG--------------------------------------------------
------------------------------------------------------------
----SHTQTVEQDRSH----------------QKGGTSTQTQQSTQGQNRGTETQGQDRS
Q---------------TSQGVT---GG--RV----------QTQAGSHTQIA--------
-----------------------------------------E------------------
------------------------------------------------------------
----------------------QDRHQTLSHVGATG------------------------
---------------------------------------------------QGQTQ----
TQSGSGERWTQVSTYEA-GE----------------------------------------
---------TVLG-------------------------GQAQAGATTVPGRQDWSSTHPT
CSV----------TGGQG-----------------------EREPA--------------
-------VVGEEWVDDHTREV---VIHRQDQGS----LHT--------------------
------------------GVPSAQGQGAAQ------------PE-GKRGTA-ATR-----
----------L--------------------------YSYFRSSKS--------------
------------------------------------------------------------
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-------------

----------------MPQLLRNINGIIEAFGRYARTEGD-CAVLTRGELKKLLEHEFAD
VIVRPHD-----------PATVDEVLRLLDEDGTGTVDFK-----------E-FLV-L--
-T---------------F-K-V-A-Q-A-C-FKT----LSESP-EGACG---S-----QA
SGSL-----DP-G----ASQEPGG-RQTAGTEV--GGSGKGQHHKG--------------
-------ND-------------------------------------------------HG
HSEQA-----------SGGQGR---------------NGTHTQG----------------
------------------------QDISCAWVSSYDR------------------QAESQ
RQERT-SQQTQAPGHGGQTQEVVESKSHQTRE------T--------------R-----S
ERQS-----QTREQDRAHQTGEIV-TGAG-------------------------------
--------------------------------------------TQT-------------
------------------------------------------------------------
---------------------------------------------Q--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------I---------------------------------------------------
------------------------------------------------------------
----GITQTVEQDRDH----------------QKGSTSTQ--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------TQHVGARE------------------------
---------------------------------------------------QGQTQ----
TQSDGGERWTQVSTYEA-GE----------------------------------------
---------TVLG-------------------------GQAQTGASTEPGRQERSSTHPR
CSV----------TGGQG-----------------------DMEPA--------------
-------VVGQEWVDDHTREV---VIQRQDQGS----LHT--------------------
------------------GVPSAQGQGAAQ------------PE-GKQGNA-ATK-----
----------L--------------------------YSYFRSSKP--------------
------------------------------------------------------------
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-------------

-----------------SPLLRSICDITEIFNQYVSHDCD-GAALTKKDLKNLLEREFGA
VLRRPHD-----------PKTVDLILELLDRDRNGRVDFN-----------E-F-L-L-F
-I---------------F-K-V-A-Q-A-C-Y--Y-A-L-G-Q-A-TG--L-D------E
E-KRA-R-C-D-G-K-E-SL-L--QD-RRQEED-Q-R-----------------------
-------------------------------RF-------------------------ES
RDRQLEEEPG-----QRRRQKRQE----EER--EL-AEG-EEQSEKQE-RLQQRDR----
--------------QRR---------DEELWR------------------Q-RRERREQE
E--R----------------RAEEEQ-LQRCK-------------------GHETEAFPD
EE-QQR----RRELQ---------------------E---LRRERREEKQQQRR------
-------------E------------------R--QERVLQEEEEKEW-RKRERVHRQEE
-----------------------------K------LQEE-------------E--PQL-
-----QRELQE-EEEQL--------QKLERQ---------------------ELKRERQA
EE----Q--QQQ---RLRREQ--------QL-RREQEEERR-----EQ---EER------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------R--EQRREQQERREQ--RL
KRE-------EE-----------ERRDW--------LKREEEKERRE---------ERLK
SEQEE--------E--RR----EHW------L-KCEEEEKRREQE------RR------E
QR-LK-RQEEEERREQRLKRQEEEERR-EQ-LLKREEERLQQERR-------------EQ
W--LKREQ-------------E---ERREQWLKREQEEERRDQL------LKREEEEKRR
QQEERREQRLKRQEEE--------ERREQLLKREEEERLEQEERREQRLKREQEERREQ-
--------------------RLKREQEE----------------------------RREQ
RLKRE-QE-ERREQLLKREE-EEERLEQEERR--EQRLKR-EQEERR-EQEE--------
----------RREQRLKREEEERLEQEKR-R-E-QLE-ERRQ-QWLRR----EQEL----
---------------A--EE---EQE---------------QA-----RERIKSQTPKWQ
WQLESE-------------------------------ADARQSK---VYSR---------
PRK-QEGQ-----RRRQEQEEKRR------------------------------------
-------------------RRER---E----------L---------QW---Q-------
----------EEEQA------QEQRRDFTWQWQAEE-----ERQRGRQRLS---------
-----A-RPSLREQRERQLRAEER----------QQREQRFLQEEE-KEQRRR--QRRE-
RERELQFLEEEEQLQRRERAQQLQEEGYGPQEDQERRRSPEQRRDQKWRWQ--LEEER--
-K---------RR-------------------------QLRKEQQ----L-----QQQE-
------E-EELQ--REE-REKRRRQEQERQYREE-EQL-QQEEEQLLREE----------
-REKRR-RQERERQYREDEEL-QQEEEQLLG--------------EE-------------
---------REKRRR-RERERQYRKEEELQQ-------------------------EEEQ
LLR---------EE-REKRRRQEQEREYRKEEELQQEEEQLLREERE---------KRSL
-QERERQYRKEEELQQEEE--QLLREEREKRRLERERR-YRE------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------EEEL---QQEEKQL---LREE------------------
------------------------------------REKRRRQELERQYREEEELQ----
--Q-------------------------------EEEQLL---RE--EQEK-RRQEPERQ
Y-----------------------------LEEEELQHQERKRRYRDEDQRRDLKW----
QWEPEKENAVRNNRVYCKRRENE-QFRQSED-SQVRDRQSQQDLQPLLDEPQ------ER
----EKRRWQQRDRHFPEEEQ----LERE--EQKE-QL------------L-R-EEKEKR
VRQGRDRRFREEEQLLQE-----------------------REEQQLSRQERDRKFREEE
LR---------RQERERKFLEE---------EQQLRRQELEQQLRHDRDRKFREEEQLLQ
ERE------------------EQQLSRQERDRKFLEEEQQLR------------------
------------QDRDRKFREEEQLLQEREEQQL-RR---------------QERDRKFL
EEEQ--------QLRQD-RDRKFREEEQLLQEREEQQLRRQERDRKFLE----------E
EQQLRQDRDRKFREEEQLLQEREEQQLRRQ------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------ERDRKFLEE
EQQLRRQEREQQKFREEEQEEQQLRRQERDRK------------------FLE-------
--EEQQLRQDRDRKFREEEQLLQEREEQQLRRQERDRKFLEEEQQLRRQEREQ-QLRHDR
DRKFREEEQLLQEREE-QQLRRQERDRKFLEEEQQLRRQER-----DRKFLEEEQQLRRQ
ERDRKFREEE---------QQLRPQELERKFLQEE--------QQLRR------------
------------------------QELERKFREEEQ--------------------LRQE
T---EE-EQLRRQERDRKFLEEEQLRQER--EEQQLRRQERNKKFREEEQQLRQ------
EREEQQLRRQERDRKFREEEQ-------------------QLRRQERDRK---------F
--LERE--------Q-QLRQDR------DRKFREEEQLKFREEEQQLRRQELER------
--KFLEEEQLRQETEE-E-QLHRQERDR-KFLEEEQLRQEREE-------KQLRRQER-D
RKFREEEQLRQEREEQ--QLRRQERDRKFREEEQ---L----PQER--------------
------------------------------------EEQQLQE-----RDGQYRAEE---
-----------QFATQEKSRRQAQELWQEEEQKRRQERERKLREDH-LRSQQEEEQRRR-
-----Q----V------RET--------QSQEGKGHGRLLE-----PGSHQFASVPV---
-------------------RSSPLYEYIQEQKSQYRP-----------------------
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-------------

----------------MPQLLQNISGIMEAFGRYARMEGD-CMVLSRGELKRLLEHEFAD
VIVNPHD-----------PATVDKVLRLLDEDNTGTVDFK-----------E-FLV-L--
-M---------------F-K-V-A-Q-A-C-FKT----MSESP-KGACG---S-----PE
SERL-----HP-G----ASQELGE-GQRSGTEV--GRVGEGQHHVE--------------
-------SG-------------------------------------------------HG
QTKQA-----------SRGQGR---------------PGTQTQD----------------
------------------------QNIGSTWVSSHDR------------------QTESQ
RQERS-SQ---------QTQRVGEGKSHQTRE------R--------------R-----S
EKQP-----QTREQDRADHTGEIV-TGTA-------------------------------
--------------------------------------------THTQA--GAIQTLEQD
RRLQTGSTHTQTQESTSGQNRGT----------------E--------------------
-----THSQDRNQTGQ-----AVTGGHVQSL-------------EGTH------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------TQTTEQDRTH----------------QTGSTHTQTQESTGGQNRGTETHGQDRS
Q---------------TNQAVT---GG--HT----------Q--EGTHTQTV--------
-----------------------------------------E------------------
------------------------------------------------------------
----------------------QDRSQTVSHGGVRE------------------------
---------------------------------------------------QGQTQ----
MQSGSGQRWTQVSSYET-GE----------------------------------------
---------TVQG-------------------------GQAQNGASTVSGRQDWSSTHPG
GSV----------TGGQG-----------------------ERQPA--------------
-------VVSAEWVDDLTRET---VFHRQDQNS----PHT--------------------
------------------GVPSAQGQGAAQ------------PE-ERRGIT-ARA-----
----------L--------------------------YSYFKSSKP--------------
------------------------------------------------------------
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-------------

----------------MTDLLRSVVTVIDVFYKYTKQDGE-CGTLSKDELKELLEKEFHP
VLKNPDD-----------PDTVDVIMHMLDRDHDRRLDFT-----------E-FLL-M--
-I---------------F-K-L-T-M-A-C-NKV----LSK---E-YCK---A-------
SGSKKHRRGHR----------HQEEESETEED--------EE-------DTPE-----HK
SGYRHSSWSEG-EEHGYS---SGHSRGTVKRRHGS-----------------------N-
-SRRLGRQG------------------------NLSSSGNQEGSQ-KRYHRSSS------
---------------------------GHSWS--------S--GKERHGFSS-GELRERI
N--------------------------KSHV-------------SPSR----ES-----G
EEYESG-------------------SG---------------------------------
--------------------------------------------SKNWERKAHGGLSYGL
EIS--GH-----E-SNST---------QSRSR-GQKLGSS-----RSCSGDSRRQSHACG
YS---------------------------------------------------------N
SSGCGRP---QN---ASNSCQSHRFGGQVNQSSYI-QSGCQSGINGGQGHDCVSGGQPSG
CGQ-----PESNSCS-QSYSQRGYGA----------------------RENGQ--PQNC-
GRQQRTG--SSQSSFCGQY-----------------------------------------
-----------------------------------------------E-------S----
-GSSQSCSNGQH-----------EYGSC-GHFSNSSS----SNEFS--------------
---KC--------G--KHRSGSGQF------T-SCEQ-----------------------
---------------------------------------HGTGL----S-----------
---QSSG---------FEQHVS---G-----------------SGQTCGQY---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------GSRSSQS-
------------SGYDE-HGSSSGK-----------------------------------
-----TSGFGQYRSGSGHSSGFGQHG-----------SGSGQSSGFGQHGS---------
G-----------------------------------------------------------
-------------SGKSSSFGQH---E----------S------GSGQSSGFG-------
----------QH-ES-------RSC-----------------------------------
-----------------------QS-S-----Y---------GQHGSGS-----------
------------------------------------------------------------
-SQSSGYGQ--HG---------------------S-------------------------
----------------------------------R-------------------------
---------------------------QTSGFGQH-----GL------------------
------------------GSGQSTG-----------------------------------
------------------------FGQYGSG------SGQSFG-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------FGQH-----------------------
-------GSGSGQSSGFGQHES-RS-G-QSS--------------------YGQHG-SSS
SQSSG-YGQHG-------------------------------------------------
------------------SRQTSGFGQHGSGS----GQS----------T---------G
FGQYG-SVL-WF--XXXXX-XXX-------------------------------------
--------------------------------X-X-------------------------
------------------------------------------------------------
-------X--------------------------XX-XXX--------XG-QSSGF----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------GQHG--------SGSA-QSSGF--GQHES------
-------TSG------------QSSSFGQHGSGSGQSSGFGQHGS-GSG-QSS-GF---G
QH-ES-RA-RQ-SSY-G-QHGS-GS-SQ-SS----------GYG-QHGSKW--TSGFGQH
-SSGSGQ---------STGFGQYGSGSGQYSGFGQHGSGSEQSSG--------FG-----
----------QHESRSGHSSCGQHGFGSSQSSGCGHNGSSSGQT-SGLGQHELSSGQSSS
FGQHGSGSGQSSGFRQHGSGS------------------------GQSSGFGQH------
ESRSHQ------------------SSFGQ---HGSGS------------------G----
----------QSSGYGQHGSS---------SGQTSG------------------------
------------------------------------------------------------
-----FGQ------QGS----SSGQ----Y------------------------------
----------------------------SGFG----------------QHGS-------G
L------G----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------QS--S
G-FGQ-H-----------GT-GSGQSSGFGQHES-RSHQSS-YGQHGS-GSSQ-SS----
---GYGQHGSS-SG--H--TTGF-GQ-------------HRS---SS---GQYSGFG-QH
GSGSG---QSTGFGQHGAGSGQSSGFGQHE-SRSH--------QF--SYGQHGSG--SSQ
SSGYGQHGSNSGQTSG------------FGQHRSGSDQSSGFGQYGLGSGQSSGFGQHGS
GTGQSSDFA--------------QHEYRSGQ-SSYGQHDTGSSQSSGCGQHESGSGP---
-------------------TTGFGQHVSGSDNF---------SSSGQHISGSGQSTG---
------------------------------------------------------------
-------FGQYGSGSGQSTGLGQGESQQVASGSTVH------------RRQETTHGQT--
--INTARH------SQFGQG---------------QSTQMGSRVSRRRR-SSQSEKSDSE
VNSRVSH----RHSEHIHTQAGSHYPESAST-----------------------------
------------------VHRRQGTTHGQR-----------------------GDTTRHS
HSGHGQSTQTASRTTGRQRFSHSDATDSEVHSGVSNR---------PHSQEQIHGQAGSQ
LGESESTV----------------------------------------------------
-----------------------HERHETTYGQTGD------------------------
------------------------------------------------------------
----ATGHGYSGHGESTQIGSR--TTERRRSGHSES-SDSEVQRSSHS------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----QSSHSEVHSEVSPTHSG-----R-TYSQAGSQYGESGSLGHGRQET----------
------------------------------------------------------------
------------------------------------------------------------
------------------THGQTGDTARHAHYGHGQSTQS--ESTTMG-RRGSGHSESSD
SEVHSGLSHRP-------------------------------------------------
------------------------HSQEHTHGQAGSQHEESESTVHEKHRTTHGQTGDST
GHAHSG------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-DTTRHGQSGH---------------GQSTQTGSRTTGRQRSSHSKSNHSEVHSDVSPTH
S-----------------------------------------------------------
-------------------------------------------------GYTYSQAGSQY
GELGSLGHGRQGTIHGQTGDTTRHGHSGYGQSTETG-----SRSTR--------------
------------------------------------------------------------
--------------TSH-------------------------------------------
--------------------------FQSHSSERQGTTHGQRGDTARHAHYGHGQSTQTG
---S-------RTTGRRGYDHS------------E-------------------------
-----------------------------------------YSDSEGHSGG---------
-----------------SHT--HSGHTHGQARSQQGESG----SAVHGRLETTHGKTGDT
TRHGHSGYGQSTETGSRST--R---TSHFQSH--SSERQRDGSSQVWK---HGSYGPAE-
-------------------------------YDYGHTGYGPSGG-RRK-SICNSHLSWSI
DSATNE--QLSRH-----------------------------------------------
------------------------------------------------------------
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-------------

----------------MSPFLDSIATIVGVFQQHARGDGD-GSGLSRRRMRELIQREFAD
SLVKPHD-----------PQTIEKILQFLEWDGDGNIDFN-----------E-FLL-L--
-V---------------F-R-V-A-K-C-C-FWF----QPR---A-PGR-DAEPRRELIP
RE-----------F-RERSQE---PQRR--------------------------------
-------EPQP-R-------PD------------------------------------RR
SC----QEPGQER-GHRRRTRRERES--AGRVREIREEQEREERDDPRRKERLRE-----
--RRH-------------------------WT-------------QERE-----------
E--EV-------AT-----------RNLRETR---ERRER--DIRDLEDGRR-QR-----
E-----------------------------------------------------------
-------------------------------------SVRVRREI--RERGEELRRRERP
C---EGE-----EE---E----------------R-RISR-------------VRHREE-
-----PLRE-R-RIDRE--------RE--------------------------LE--VSE
RR-------------------------T----RA-REEEVATV------------RQRET
QE------R--REREIRDLE--ADGRR--------------------EQEVVRRE-----
-I------------------------------QE--RGEELRRRERPRER-E---E----
E----ERRICSRRDREEPL----RERRLNHERELEERGEELRRRER--------------
-------------------------------------------------------PQREE
PLR----------E--RRIDR-EQ---------------------------------ELE
RE-------------E-----------------PLRERRIDRERELEVS----------E
R--WTRER--EE------EKRE---TER---------E---------EVRREIRERGE-E
L---------------------------------------R--RREHLMRR---------
-------------EI--RE-----------------------------------------
------------------------------------RGEELRRRERPCEGEE---EERRI
SRVRDREEPLR-ERKIDRERELEVEARERRERDIRDVEEDTRRGQERRSRQTRERAA---
----------EEVRL---------------------------------------------
------------------------------------------------------------
-------------------------------E-------VLEEEE---------------
-------------EEE---LEQG---R---------------------------------
------------------------------------------------------------
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-------------

----------------MTDLLRSVVTVIDIFYKYTKQDGE-CGTLSKDELKELLEKEFRP
ILKNPDD-----------PDTVDVFMHMLDRDHDRRLDFT-----------E-FLL-M--
-V---------------F-K-L-A-M-A-C-NKV----LGK---E-YCK---A-------
SGSKKRRHGHQ----------HQNEESET--E--------E--------ETPR-----QK
LGFRHSSWSEG-EEHGHS---SGSSWGTAKHKRR--------------------------
------------------------------------------------------------
-------------------------------------------------SNS-RRLERQG
E--------------------------LSSS---------------------EE------
---P-R-------------------KKHHG------------------------------
----------------------------------------SSS-GYSWSSNEERHGSSS-
--EELEE----KI----------------NKSHGRPSR----------------ESGEES
------------------------------------------------------------
--------------------------------------KSGGKSESESKGR---------
-------------KG-HSGLS---------------------------------------
-----------HGLEKNKH-----------------------------------------
--ESNSTQSRKG------------------------------------------------
--------------------------G--------------------------------E
QKL---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------G----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------P------SSANSGNS----
--------------------------------------------KLQSHACG--------
------------------------------HSNSS-----GCCRPQN---ASSSCQ----
---ASRSGR--QG-------------------NQSCT-QSRC-Q---SGNSGGQGYGCVS
GG----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-Q-SSR-CCQNE----PRS-CS--------------------------------------
------------------------------------------------------------
---QSAS----------------------QR--GYGSQQCSQPQNCG-------------
------------------RQ---QRMGPSHSSCCGS------------------------
---------GATQTSTNSQHGTSS------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------CG
H-----------------------------------------------------------
-------------------------------------------SSSN--HQK--------
-----GCNPN------------EFSKCGQHGSGSGQ---------------PSCCE----
---------------------------------------------QHGTNSRQSSGFKQH
-GHGSGQ---------SC--------------CGQHGTASGQSSG--------CG-----
----------------------QHGSNTDQSSGFGQHESGPGQS-SGYGEHGYGSGQAGF
GHQ---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------ESGGGQSSGYGEHEY-------------
---------------------------GSGQSSGFGHQESGGGQSSGFGHE-------GS
G----G-----------GQSSGYGEHGYGSGQA----------GFGQHKSGSGQSSGYGE
------------------------------------------------------------
----------HEYGSGQSSGFGHQESGGGQSSG-YGEHRYGSGQSSGFGHQESGGGQT--
--YGNGEHDS--------------------------------------------------
------------------------------------------------------------
----------GSGQ--VSSYERHGSGSGQSF-----------------------------
--------SSGQGNYE---------HAEYNHGDSG-TTGHTGQRNPQRQSRDS-------
-------------------SRQ--------------------------------------
----------------------------------------LQEGHKQPSHSGPRGSPVH-
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------P----
--ESSEGEEHS------------------------------------------VVSHR-H
SGSSQG-QGGVPHGESS------STGQSRDSSRQP--------------QVGHE------
--------------------------H-----------------SSQ-------------
SGSGRSP-----------------------------------------------------
--------------------------------------RGSPVH----------------
------------------------------------------------------------
----------------------------PESSEGEEH------SVVSH-RHSGSSQGH--
-GGVPHG--ESGSPVHGR----------QG-----------------------------A
PQR---------------------------------------QS----------------
-------RDSSR---QP-QAGH----EHSSQSGSGRSPRRS----PV-HPESSEGEEDSV
--------------VSHRHSSSSQGH------------GGVPHG----------------
----------------QSGSSVHSR-----------------------QGTPQGQSRDSS
RQPQAGHEHSSQSGSGRSP--RGSPVHPES-----------------S--E------GEQ
HSVVS-------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------HR-
----HSGSSQGHGG-------------------------VQHG---ESGSPVHGRQGAPQ
RQSRDSRRQPQAGHEHSSQSD------------SGR------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---SPRGSPVHPESSEGEQHSVV--SHGHSGSSQGHGGVQ---H---GESSSTVHGRQGA
PQRQSRDSSRQPQARHE-----H-------------------------------------
------------------------------------------------------------
-SSQSGSGRSP--R---------GSPV-------------------------HPESSQGE
QH-SVVSHRDS------GSSQGHGGVQH--------------------------------
------------------------------------------------------------
GESGSPVHGRQGTPQRQSRDSSRQPQAGHEHSSQSGSGRSPRGSPVHPESSE--------
---GE------EH-SVVSHRHSSSSQGHGAVQH---------------------------
------------------------------------------------------------
----------------------G-------------------------------------
-------QSGSSVHGRQGTPQRQSRDSS----RQP---Q--------------EGHEHSS
----------------QSGSGRSRRGS--PVH---------PESSEGEEHS---------
-------VVSH----------RHSSSSHGHGGVPH---G-ESGSPVHGRQGAPQRQSRD-
-----------------------------------------------------------S
S------------------R----------QPQAGH-EHSSQ------------------
---------------SGSGRNPR-------------------------------------
--------GSPVH-PESS-----EGEEH--------------------------------
------------------------------------------------------------
------------------SVVSHRHSGSSQ------------------------------
------------------------------------------------------------
-----------VHERQGAPQRQSRDSSRQPQAGHEHSSQSGSGRSPR-------------
-----------GSPVHPESSEGEEHSVVSHRHSGSSQGQGGV-----PHGESSST-VHGR
QGAPQRQSR------DSSRQPQAGQEHS-------------SQSGSGRSPRGSPVHPES-
----------------------SEGEEHSVVSHRHSSSSQGHGGVQHG-ESG--------
------------------------------------------------------------
----SSVHGRQGAPQRQSRDSSRQ-----------PQAGHEHSSQSGSGRSPRGSPVHPE
SSEGEEHSVVSHRHSS----------SSQGHGRVPHGES---------------------
------------------------------------------------------------
--------GSPVHGRQGAPQRQSRDSSRHGHEHSPQSG---------------SERGPRG
SPVHP----ESSQGEQ------HSVVSHR--HSGSSQGYGGVQHSDSGSAVKGGQG--AP
QRHSGSSQVQHSDSGS------AVK------GGQGAPQRQSRD-----------------
-SSRQPQAGHEHSS-------QSGSGRSPRGSPVHPESSEGEQ-----------------
-----------HSVVSHRHSSS--SHV---------------------------------
-----------HGGV---------PHGES-GSPVHGRQGAPQRQSRD-------------
----------SSRQPQAG--HEHSS-----QSGSGRSPRGSPVHPESSQGE---QH----
-----------------------------SVVSHRHSSSSQGHGGVQH---GESGSPVHG
RQGAPQRQSRDSSRQP-------------------------------QAGH---------
--------------------------EHSSQSGSGRSPRGSPVHPESSQGEQHSVVSHRH
SGSSQGHGGVEH---SDS-----GSAVKGGQGAPQ--RQSRDS-----------SRQPQA
GHEHSSQSGSGGSPRGS-----PVHPESSEGEEH-----SVVSHRHSSSSQGHGGVQH--
----------------------------GESGYSYSASYSTHGQSS--------------
--------------------DHVR--KQPSRAHGQSLRHHFQSSSTRNQYVSNQRWRHGS
YGREDYDYGQSGYGPSGGSRTSSRNSSPLRSAHQAM--NTLASRYGQSFSLSQNVGSK-A
NEGMGGLVLKYGESEPDHGQPIDYYNLTESCTP-GMLTSSH--------------GH---
--------------------------------------------------------SLVT
GEHSSDCDVQYEYSTKGKPEPT-----QSQPIDQSGFGHSQYISFHVHS-----------
ESNSIGNQSGFSTNNRQV-------------------------YSHGQSSD-NQLSSDSR
NRNQKSFPNNSLQSLYCMETKEYKYFPSA------------------TTLGAGRQGQEAG
FNPSGTTR-KISQFSDDKKT----RDSESRGYHE----RGEIYSGSAYEDSNTPLYTYVQ
EQRHHHFY----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
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-------------

----------------MPQLLRNINGIIEAFRRYARTEGN-CTALTRGELKRLLEQEFAN
VIVKPHD-----------PATVDEVLCLLDEDHTGTVEFK-----------E-FLV-L--
-V---------------F-K-V-A-Q-A-C-FKT----LSESP-EGACG---S-----QE
SGSL-----HS-G----ASQELGE-GQRSGTEV--GRAGKGQHYEG--------------
-------SS-------------------------------------------------HR
QSQQD-----------SRGQNR---------------PGAQTQG----------------
------------------------QATGSAWVSSYDK------------------QAESQ
SQERT-SPQIQLSGHTEQTQKAGEGKRNQTTE------V--------------R-----P
ERQP-----QTREQDRAHQTGETV-TGSG-------------------------------
--------------------------------------------TQTQA--GATQTVEHD
SSHQTGRTSMQTQEATNDQNRGT----------------E--------------------
-----IHGQGRSQTSQ-----AVTGGHAQIQ-------------AG--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------THT-----------------------------------------------
------------------------------------------------------------
---QTPTQTMEQDSSH----------------QTGSTSTQTQESTNDQNRGTENHGQGRS
E---------------TSQAMT---GG--HA----------QIQAGSHTQTV--------
-----------------------------------------E------------------
------------------------------------------------------------
----------------------QDRSQTVSHGGARE------------------------
---------------------------------------------------QGQTQ----
TQPDSGQKRTQVSNPEA-GE----------------------------------------
---------TVPG-------------------------GQAQTGASTESGSQEWSSTHPR
RCV----------TEGQG-----------------------DRQPT--------------
-------VVGEEWVDDHSKET---MILRLDQGN----LHT--------------------
------------------SVSSAQGQDAAQ------------PE-EKRGIT-ARE-----
----------L--------------------------YSYLRSNKP--------------
------------------------------------------------------------
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-------------

----------------MPQLLRNINGIIEAFRRYARTEGD-CAVLERGELKRLLEKEFAD
VIVKPHD-----------PATVDEVLRLLDEDDTGTVEFK-----------E-FLV-L--
-V---------------F-K-V-A-Q-A-C-FET----LSEGP-EGACG---S-----QE
SGRV-----AP-A----ATQEPGA-GQRGSTAV--GRPGNRQGPAG--------------
-------SS-------------------------------------------------DT
QNEQA-----------SGGPGG---------------PEPQTRG----------------
------------------------QDISSAQVSHQDR------------------QSASQ
RQEGV-SQSTQARGHVEQAQRTQEDKSPQTRE------R--------------G-----T
ERQP-----QARDQDRAHQTRGHI-QTQT-------------------------------
--------------------------------------------RSQTQ--THSHTTEQD
RSQQSGSTSTQPRESTR----GT----------------E--------------------
-----AHSQDGRQTSQ-----VVTGGHIQAQ-------------TRSQTQTHTHTTEQDR
SQQTGSASTQPR---ESTCGQARGTE-----------------------------THSQD
RYQ---------------TRQVVTGG----------------------------------
-------HIQTQPGSQTQTYTQP--------------RELDRSQ--------------QR
GNTSIQSQESPRESTRGTET----------------------------HSQDGRQTSQVV
TGGHIQAETRSQT-----------------------------------------------
------------------------------------------------------------
---QTHTHTTEQDRSQ----------------QTGSASTQPRESTCGQARGTETHSQDRY
Q---------------TRQAVT---GG--HI----------QTQGGAPQA-V--------
-----------------------------------------G------------------
------------------------------------------------------------
----------------------QDSGPITSHPGAGE------------------------
---------------------------------------------------QGQPQ----
RQPGSSQRQTQVSNCEA-GE----------------------------------------
---------TVLG-------------------------GQAQTGASTVTGRQDRSSTQPA
RSA----------TGAQG-----------------------EREPT--------------
-------VVHQEWVDDHTRET---VIRRQDEGS----LHA--------------------
------------------SVPSAQGREAAQ------------PE-GKRGLT-ARG-----
----------L--------------------------YSYFKSSKP--------------
------------------------------------------------------------
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-------------

----------------MPRLLRDVLCVIETFHKYASEDSN-RATLTGRELKQLLQGEFGD
FFQPCV------------LHAVEKNSNLLNIDSNGIISFD-----------E-FVL-A--
-I---------------F-N-L-L-N-L-C-YLD----IQL-----LLS---S-ELRQ--
-VTKP-EKEKPDD------VYLQATT---GD---------GQWTAG---TSPT-------
-----------QEER----------------MLPS----------------------GMA
SLSQLIPEES----------------GAVGNNRVD-PWREAKTHNFPGEASEYNNP----
---KNQHL-------------------------------------------------EGD
-------EQIQEVAQDVQTTEDNEGQ-LKTNK---PMAGSKQTSSPTK-RKG-QDKKISR
EGD-EP----VREQSVS------KIRDQF---------------GEQEGNLE--------
--------------------------------------------TQNSPPEEATQRPSE-
-----------------DQ----------KVRTEK-E--K----------YSNTQEPPL-
------Q------------------GEDE-P-------------SSERA---DLP-----
EQAAARTLSQTQ---KSTDPEDV--CRT----FDTQELGKDAD------------QTPAA
------------TKN--SGEPEDYGR---------------------TSETQE-------
------------------------------------------------------------
------------------------------------------------------------
------------------KESETKDLPVQGGSRNG----SETSDMR--------DERKER
RGPKTHETAGQ-KE--------------------RDR---------------------KT
RPLVL-------------ETQTQDEQY--QEFQGLS-------KSKDVEKGSET------
-----------------------------------------QYLSSEGGDQT-----HPE
L--------------E-------GT----A-VSGEEAEHTKEGTTEAFVNSKNTPAAARS
LGAGE----------STQD-----------------------------------------
--------------------------------------------LAPLEK-QSAGENSRV
TKTHDK--PVEEEDGYQ-----------------------------------GEDPASPF
TQNEEGSSETPSSLASEEENSSSETS---------------E------------------
--------LPAQRDSK------------------SQGDPHGESV---------QGGHNNI
PDT---------------------------------------------------------
------------------------------------------------------------
---------------------------------------------QRRRTPGEKNRAQEA
V------VPAVR------------------------------------------------
-GEDVQLTEDQEQPSRGEHK-Y--------QGPG-----T-KGLGAAVEPSGHPEAQ---
---ESTAGD--ENRKSLEIEITGALDED--FTDQLSLMQLPGKGD---------------
-------------------SRNELKVQGPSSKEEKGRATEAQNTMLKSLDEDNSASH---
--KIQLETKE-------TVTS-EEEDESPQGLAGEGGDQKTPS-KKEHNSSVPWPSLEKQ
MQRDQEPCFAERGAVHSSPLYQYLQEKILQQTNITQE--------------------DHQ
K---------------------------------QVQIAQASGPE---------LCS---
-VSLTSETSDFSVFFNYNQASQ---------------SYTRGLPLDESPAGA---PAPQA
LEDKQGHPQRERLVPQREASTT----------------------------------K---
-----------------------------Q------------------------------
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-------------

----------------MPPLLQNINGIIEAFGRYARTEGN-CTVLTRGELKRLLEQEFVD
VIVKPQD-----------PATVDEVLRLLDEDNTGTVEFK-----------E-FLV-L--
-V---------------F-K-V-A-Q-A-C-FQT----LSERP-EGACG---P-----RT
SGSL-----HP-G----ASAELGE-REKSGPDG--GRSGKGQHHEG--------------
-------NG-------------------------------------------------RR
QREQV-----------SKGQDR---------------TGTQTQG----------------
------------------------QDIGTTWVSGDVR------------------QARSQ
TQERT-SQQEQVLGHGEQPQTAPESQSQ--TR------D--------------R-----S
DRQS-----QTREQDRTCHTGDTV-TAVG-------------------------------
--------------------------------------------T---------------
------------------------------------------------------------
---------------------------------------------QTQVGSHTQAV----
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------EQDRSH--------------RT
GSTSPQAQELTHDQNRGTET----------------------------QGQDRSQTSQVV
TGRQVQTQAG--------------------------------------------------
------------------------------------------------------------
----SHTQTVEQDRSH----------------QTGSTSPQTQESTHDQNRGTETQGQDRS
Q---------------TSQVVT---GG--QV----------QTQAGSHTQTV--------
-----------------------------------------E------------------
------------------------------------------------------------
----------------------QGRHETINHEGAGE------------------------
---------------------------------------------------QGQTQ----
IQSGNGKIWTQVSNSEV-GE----------------------------------------
---------TVLG-------------------------GQAQTGENSGPGSQDWSSTQPK
CSV----------TGGQG-----------------------KREPT--------------
-------VVSQEWIDDQTRET---VVQSQAQGS----LHT--------------------
------------------SIASAQSQGAAQ------------LE-GKQGGT-AKR-----
----------L--------------------------YSYFKSSKP--------------
------------------------------------------------------------
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-------------

-----------------SPLLRSICDITEIFNQYVSHDCD-GAALTKKDLKNLLEREFGA
VLRRPHD-----------PKTVDLILELLDRDRNGRVDFN-----------E-F-L-L-F
-I---------------F-K-V-A-Q-A-C-Y--Y-A-L-G-Q-A-TG--L-D------E
E-KRA-R-C-D-G-K-E-SL-L--QD-RRQEED-Q-R-----------------------
-------------------------------RF-------------------------ES
RDRQLEEEPG-----QRRRQKRQE----EER--EL-AEG-EEQREKQE-RLQQRDR----
--------------QRR---------DEELWR------------------Q-RRERREQE
E--R----------------RAEEEQ-LQRCK-------------------GHETEAFPD
EE-QQR----RRELQ---------------------E---LRRERREARAGGEA------
-------------R------------------A--GGEARAAA-----------------
-----------------------------------------------------E--A---
---------------------------------------------------------RAG
G----------------------------EA-R-AAGEARA-----A-------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------AEARGGGEA--R-
------------------------------------------------------------
---------------------------------LCEEERGRRGA---------------S
EE-RR-EREEEERREQRLKRQEEEERR-EQ-LLKREEERLQQERR-------------EQ
W--LKREQ-------------E---ERREQWLKREQEEERRDQL------LKREEEEKRR
QQEERREQRLKRQEEE--------ERREQLLKREEEERLEQEERREQRLKREQEERREQ-
--------------------RLKREEEERLEQEERREQW----------LKREQEDRREQ
LLKREEEE-ERREQLLKREE-EEERLEQEERR--EQRLKR-EQE-------E--------
----------RREQRLKREEEERLEQEKR-R-E-QLE-ERRQ-QWLRR----EQEL----
---------------A--EE---EQE---------------QA-----RERIKSQTPKWQ
WQLESE-------------------------------ADARQSK---VYSR---------
PRK-QEGQ-----RRRQEQEEKRR------------------------------------
-------------------RRER---E----------L---------QW---Q-------
----------EEEQARRQQQEEEQRRDFTWQWQAEE-----ERQRGRQRLS---------
-----A-RPSLREQRERQLRAEER----------QQREQRFLQEEEEKEQRRR--QRRE-
RERELQFLEEEEQLQRRERAQQLQEEGYGPQEDQERRRSPEQRRDQKWRWQ--LEEER--
-K---------RRHYTVYA-------KP------ALRGQLRKEQQ----L-----QQQE-
------E-EELQ--REE-REKRRRQEQERQYREE-EQL-QQEEEQLLREE----------
-REKRR-RQERERQYREDEEL-QQEEEQLLG--------------EE-------------
---------REKRRR-RERERQYRKEEELQQ-------------------------EEEQ
LLR---------EE-REKRRRQEQEREYRKEEELQQEEEQLLREERE---------KRSL
-QERERQYRKEEELQQEEE--QLLREEREKRRLERERR-YRE------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------EEEL---QQEEKQL---LREE------------------
------------------------------------REKRRRQELERQYREEEELQ----
--Q-------------------------------EEEQLL---RE--EQEK-RRQEPERQ
Y-----------------------------LEEEELQHQERKRRYRDEDQRRDLKW----
QWEPEKENAVRNNRVYCKRRENE-QFRQLED-SQVRDRQSQQDLQPLLDEPQ------ER
GGKQEKRRWQQRDRHFPEEEQ----LERE--EQKE-AKRRDRKFQEEKQLLRE--EKEKR
VRQGRDRRFREEEQLLQEREEQL-------------------------RQERDRKFREEE
LR---------RQERERKFLEE---------EQQLRRQELEQ------------------
------------------------------------------------------------
----------------QKFREEEQLLQEREEQQL-RR---------------QERDRKFL
EEEQ--------QLRQA-RDRKFREEEQE-----E-------------------------
------------------------QQLRPQ------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------ELERKFLQE
EQQLRRQEL---------------------------------------------------
-----------E------------------------------------------------
-RKFREEEQLRQETEE-EQLRRQERDRKFLEEEQLRQEREEQQLPQQLRQEREEQ-----
--------------------QLRRQERDRKFREEE--------QQLRR------------
------------------------QERDRKFLAELQ--------------------LRRQ
E---RE-Q-QLRQDRDRKFREEEQLLQER--EEQKFRE----------------------
------------------EEQ-------------------QL------------------
-----------------RRQEL------ERKFLEEEQLRQETEEEQLHRQERDR------
--KFLEEEQLRQEREE-Q-QLRRQERDR-KFREEEQLRQEREE-------QQLRRQER-D
RKFREEEQLPQEREEQ--QLRRQDRDRKYRWEEEQLQL----KKQE--------------
------------------------------------EQRLRQE-----RDGQYRAEE---
-----------QFATQEKSRRQAQELWQEEEQKRRQERERKLREEH-LRSQQEEEQRRR-
-----Q----V------RET--------QSQEGKGHGRLLE-----PGNHQFASVPV---
-------------------RSSPLYEYIQEQKSQYRP-----------------------
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-------------

----------------MSRLLRGVFCVVKIFHKYATEDGDNQATLTRTELRQLLEGEIGD
FLQPHV------------FHAVERKLNLLDFDRDGTISFE-----------E-FLL-A--
-I---------------F-S-L-L-N-P-S-CLD----I-S-----LLN---S-EPRL--
-MSKS-EK--IDA------VDFGAVA---GN---------IQQVVG---VGPT-------
-----------QERL----------------IFPS----------------------EMA
SSGQPSDEEG----------------EVGDEPMVS-PCEDITTHDLPRNVSEPNDP----
---ENQQP-------------------------------------------------KED
---------AREVAENVPATEYNGVQ-FKRNT---AVEVPKQSTSSTQ--------EIPR
ERS-KP----SRRQSDT------KISDHM-------------------------------
-----------------------------------------------------IQRPTE-
-----------------DE------------------ENT-----------STTQDPFL-
------Q------------------KKG-PS-------------GSEHT---DLP-----
VVAATGKSSQTQ---ETFELTDD--TKL----SETQETGKDGG------------RIPPE
------------TTN--LEEPNADAR---------------------AAESLGLPAQE--
------------------------------------------------------------
------------------------------------------------------------
------------------REHKIRGQSVQSRSRNV----SETSSRG--------E-----
------QEEEW-KE--------------------HER---------------------IT
RSPAP-------------EAETRDEKC--QESPGSW-------KENDAKKGSAV------
-----------------------------------------KDPSSEEGNQN-----LPE
V--------------K-------ED----S-ISGKEARHSEEDTVDALAINKNSPAAEET
LGTRE----------RSQE-----------------------------------------
--------------------------------------------LAPLEK-QSQRKKHRA
TRTQDK--PVRKEDHDE-----------------------------------GEDSELSV
TQSDEGFCETPNSLAPEAGKSSSEIA---------------E------------------
--------PHVPEDAQ------------------SQADHHGDAK---------QESHTNN
PDP---------------------------------------------------------
------------------------------------------------------------
---------------------------------------------RKQGAPGKSSREQEA
V------VLSIQ------------------------------------------------
--EDEQLPEGQGQSARE-KHDG--------LSSR-----TKGGPGAAVESSEGEEVQ---
---EAIAGS--ENRKSLEAESSEAQ-----------------------------------
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-------------

------------------QLLKSIVNIVEVYNQYAKSDCD-GTALSKKALKNLLQREFGD
ILRRPHD-----------PQTVDLVLQLLDRDCNGVVDFN-----------E-FLL-L--
-L---------------F-K-V-A-Q-A-C-YYA----LSQAT-GNEGK-----------
------------------------------------------------------------
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-------------

MEPPRGFFILSRLTSKMPQLLRNINGIIEAFRRYARTEGS-CTALTRGELKRLLEQEFAD
VIVKPHD-----------PATVDEVLRLLDEDHTGTVEFK-----------E-FLV-L--
-V---------------F-K-V-A-Q-A-C-FKT----LSESP-EGACS---S-----QE
SGSL-----HS-G----AWQELSE-GQRSGTEV--GRAGKGQHYEG--------------
-------SS-------------------------------------------------HG
QSKQP-----------SRGQSR---------------PGAQTQG----------------
------------------------QATGSAWVSSYDR------------------QAESQ
SQERT-SPQIQCSGHTEQTQRAGEGKRHQTTQ------M--------------R-----P
EREP-----QTREQDRAHQTSETV-TGSG-------------------------------
--------------------------------------------TQTQA--GATQTVEQD
SSHQTGSTSTQTQGSTNGQNSGT----------------E--------------------
-----IHGQGRSQTSQ-----AVT-GHAQIQ-------------A---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------GTHT-----------------------------------------------
------------------------------------------------------------
---QTPTQTVEQDSGH----------------QTESTSTQTQGSTNGQNRGTEIQGQGGS
Q---------------TSQAVA---GG--HA----------QTQAGSHTQTV--------
-----------------------------------------E------------------
------------------------------------------------------------
----------------------QDRSQTVSHGGAGE------------------------
---------------------------------------------------QGQTQ----
TQPGSGQKWTQVSNPEA-GE----------------------------------------
---------TVPG-------------------------GQAQTGASTESGRQEWSSTHPR
HNV----------TEGQG-----------------------DIQPT--------------
-------VVGEEWVDDHSRET---AIFRLDQGN----LHT--------------------
------------------SVSSAQGQDAAQ------------PE-EKQGIT-ARE-----
----------L--------------------------YSYLRSNKP--------------
------------------------------------------------------------
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-------------

----------------MTDLLRSVVTVIDVFYKYTKQDGE-CGTLSKDELKELLEKEFHP
VLKNPDD-----------PDTVDVIMHMLDRDHDRRLDFT-----------E-FLL-M--
-I---------------F-K-L-T-M-A-C-NKV----LSK---E-YCK---A-------
SGSKKHRRGHR----------HQEEESETEED--------EE-------DTPE-----HK
SGYRHSSWSEG-EEHGYS---SGHSRGTVKRRHGS-----------------------N-
-SRRLGRQG------------------------HLSSSGNQERSQ-KRYHRSSS------
---------------------------GHSWS--------S--GKERHGFSS-GELRERI
N--------------------------KSHV-------------SPSR----EF-----G
EEYESG-------------------SG---------------------------------
--------------------------------------------SKSWERKGHGGLSCGL
EIS--GH-----E-SNST---------QSRSR-GQKLGSS-----RSCSGDSRRRSHACG
YS---------------------------------------------------------N
SSGCGRP---QN---ASNSCQSHRFGGQVNQSSYI-QSGCQSGINGGQGHDCVSGGQPSG
CGQ-----PESNSCS-QSYSQRGYGA----------------------RENGQ--PQNC-
GGQQRTG--SSQSSFCGQY-----------------------------------------
-----------------------------------------------E-------S----
-GGSQSCSNGQH-----------EHGSC-GRFSNSSS----SNEFS--------------
---KC--------G--KHRSGSGQF------T-SCEQ-----------------------
---------------------------------------HGTGL----S-----------
---QSSG---------FEQQVA---G-----------------SSQTCSQY---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------GSRSSQS-
------------SGYDE-HGSSSGK-----------------------------------
-----TSGFGQHRSGSGHSSGFGQHG-----------SGSGQSFGFG-------------
------------------------------------------------------------
---------------------QH---G----------S------G---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------S-------------------------
----------------------------------G-------------------------
---------------------------QSSGFGQH-----ES------------------
------------------RSCQSTG-----------------------------------
------------------------FGQYGSG------SGQSSG-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------FGQH-----------------------
-------GSGSGQSSGFGQHES-RS-G-QSS--------------------YGQHS-SSS
SQSSG-YGQHG-------------------------------------------------
------------------SRQTSGFGQHGSGS----GQS----------T---------G
FGQYG-SSL-GQ--SSGFG-QHG-SGSGQS---SGFGQHESTS--GQS------------
--------------------------------S-Y-------------------------
------------------------------------------------------------
-------G--------------------------QH-GFG--------SS-QSSGC----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------GQHG--------LSSG-QTSGF--GQHEL------
-------SSG------------QSSSFGQHGSGSGQSSGFRQHGS-GSG-QSS-GF---G
QH-ES-RS-HQ-SSY-G-PHGS-GS-GQ-SS----------GYG-QHGS-----------
---SSGQ---------TSGFGQQGSSSSQYSGFGQHGSGLGQ------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------S--S
G-FGQ-H-----------GT-GSGQFSGFGQHES-RSHQSS-YGQHGS-GSSQ-SS----
---GYGQHGSS-SG--H--TTGF-GQ-------------HRS---SS---GQYSGFG-QH
GSGLG---QSSGFGQHGTGSGQSSGFGQHE-SRSH--------QS--SYGQHGSG--SSQ
SSSYGQHGSSSGQTSG------------FGQHRSGSGQSSGFGQYGLGSGQSSGFGQHGS
GTGQSSGFA--------------RHEYRSGQ-SSYGQHGTGSSQSSGCGQRESGSGP---
-------------------TTGFGQHVSGSDNF---------SSSGQHISGSDQSTG---
------------------------------------------------------------
-------FGQYGSGSGQSTGLGQVESQQVASGSTVH------------GRQETTHGQT--
--INTARH------SQSGQG---------------QSTQTGSRVSRRRR-SSQSENIDSE
VHSRVSH----RHSEHIDTQVGSHYPESGST-----------------------------
------------------VHRRQGTTHGQR-----------------------GDTTRHS
HSGHGQSTQTGSRTTGRQRFSHSDATDSEVHSGVSHR---------PHSQEHTHGQDGSQ
LGESQSTV----------------------------------------------------
-----------------------HERHETTYGQTGD------------------------
------------------------------------------------------------
----ATGHGYSGHGQSTQIGSR--TSGRRGSGHSES-SDTEVHSGGSHRPHSQEQTHGQA
RSQHGESRS--TVHERHGTTHGQTGDTTRY----AHY---HNGQSAQRGSRTTG-RG-SG
HSEYSDSELYS-----------------------------------------GGSHTYSG
QTHGQAGSQHGESDSIVHERQQTTHGQTGDTTRHA---------------------HYGH
GQSTQRGSRTAGKRGSGHSEYSDSEGHSGGSHTH--SGHTHGQAGSQHGESGSAVHGRQG
TIHGQT-------------------------------------------------GDTTR
HAHYG---------------HGQSTQTGSRTTGRRGS-----------------------
------------------------------------------------------------
-GHSEYSDSEGHSGGSHTHSG-----H-THGQAGSQHGESGSAVHGRQGTTQGQTADTTR
HGQS----GHGES-------------------------I-QTGSRTIGRRG-SGHSEYSD
SEGH-----------------------------SGVSHTHSGHTHGQAGSQH------GE
SES------TVHERQQT-THGQTGDTTRHAHYGHGQSTQR--GSRTTG-RRGSGHSEYSD
SEGHSGVSHTH-------------------------------------------------
--------------------------SGHTHGQAGSQHGESESTVHERQQTTHGQTGDIT
EHGHSSHGQTTQTGSRT-----------------------------------------TG
RRGSGHSEYSDSEGHSGVSHTHSG---HT----------------HGQAG---------S
QHVESGSAVHGRQGTIHGQTGDTTRHGQSGHGES-------IQTSS--------------
-------------------------RTAGRRESGHSEYSDSEGH--SGGSHTHSGH----
-------------------------------THG-QAGSQHGES----GSAVHGRQGTIH
GQTGDTTRHGQSGHGQSTQTG------SRTTGRRGSG-----HSEYSDSEGHS-GVSH--
---------------THSGH----------------------------------------
--THGQAGSQHGESG---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------SSGHGRQGTTHGQTGDTTRH-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------AHYGH---------------GQSTQRGSRTTGRRGSGHSEYSDSEGHSGVSHTH
S-----------------------------------------------------------
-------------------------------------------------GHTHGQAGSQH
GESGSAVHGRQGTIHGQTGDTTRHGQSGHGQSTQTG-----SRTTG--------------
------------------------------------------------------------
--------------RRGSGHSEYSDSEGHSG-GSHTHSGHTHGQAGS-------------
----------------------QHGESGSAVHGRQGTIHGQTGDTTRHGQSGHGESIQTG
---S-------RTIGRRGSGHS-----------DE-------------------------
-----------------------------------------YSDSEGHSVG---------
-----------------SHT--HSGHTHGQAGSQHGELG----SVIHGRLETTHGQTGDT
TRHGHSGYGQSTETGSRST--R---TSHFQSH--SSERQRHGSSHVWK---HGSYGPA--
-----E-------------------------YDYGHTGYGPSGG-RRK-SICNSHLSWSI
DSATNE--QLSRH-----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-------------

----------------MSHFLDSVSTIITVFHQHAKEDGD-QSKFNRRKMKEFIQKEFAD
AIVNPHD-----------PQTIDKILQFLEWDGDGEIDFN-----------E-FLL-L--
-V---------------F-R-V-A-K-A-C-YWY----LQK---G-QRL-LQRTKL--IT
SSKTVQEPEIKN---RGSRQQFQEEESRTLE-----R----NRH------PPC-------
-------IPEP-R-------DT------------------------------------RV
QDLETHEETGSHC-QQRNTQSR-ADARQSTRPREMIPQEYEEQNQEPCDQRSSRR--RQ-
-QPELDRL----GDL--QN------HKRGSLKTA-HRDERQNQE-KPHR-----------
E--QL-------AD-----------VR--SCS---HSCEP--QLLPDRRSGRQPRESTL-
PVYDQR----------NHRP----------------------------------------
---------------------------------------------QDQEAVAHGRSSRRP
H---EPE-----EADRGR-------------------RNQ-------------IQKPEL-
-----LKDE-R-SRNHL--------RELEQK---------------------ELE--RSS
RQ--------LC---KSE-YLDSERLHQ----SYLQEPLVIEH------------RYNNT
KE------LE-EDYYEQGKT--QKGRR--------------------PRESMTYE-----
-RTREDIV---AEAEA---DIEI-----QHVIRNRERKEEARR-----------------
------------------------------------------------------------
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-------------

----------------MTDLLRSVVTVIDVFYKYTKQDEE-CGTLSKDELKELLEKEFRP
ILKNPDD-----------PDTVDVIMHMLDRDHDRRLDFT-----------E-FLL-M--
-V---------------F-K-L-A-L-A-C-NKV----LGK---E-YCK---A-------
SGSKKRRHGHQ----------HQEEESETEED--------EE-------DTPG-----RK
SGYRHSSWSEG-EKHGYS---SGDWRGTVKRRHGS-----------------------N-
-SRRLGRQG------------------------NLSSSGNQERSE-KRHHRSSS------
---------------------------GHSWS--------S--GKERHGSSS-GELGERI
N--------------------------KSHV-------------SPSR----ES-----G
EEYESG-------------------CG---------------------------------
--------------------------------------------SKSWGRKGHGGVSCGL
ETS--QH-----E-SNST---------QSRSR-GQNT-----TTCGGGDKGKSQ---NQV
YQ---------------------------------------------------------E
VSEYTVR---MW---AINREEALRRGVTMERK-------EQTQV-------------PSA
------------------------------------------------------------
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-------------

----------------MPRLLRDILCVIETFHSYAQEDSN-EATLTFRELKQLIQGEFGD
ILQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX----XXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXX-XXXXXXXXXXX-
-XXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXX-----XXXXXXXXE----PERKDKL-TSE---QADLPEQTASQKMF----
-------------QMQKTA------SSENVSSLAETQETVEDAARAPTKIKSSAELEDSE
E--KA-------KSQDLPTQEKDETKDLNFQGDSKN--IPEISAVDVKNKEGREPEVHEE
AGQKES----V----RPHQPSVLED--HTQDEKMHEGLQELSKHGDTDGPKTRESASEAG
NQNNHETKKDLCQEEGTAEALASSKNDPKEEGVPETIERIQESTPLGWESQ---------
----------------------------------N-IGKI-------------Q------
--------------NKL--------VKE--------------------------------
------------------------------------------------------------
----------------------------------------------KAGEPVQDPEATV-
-SQKEKGL---SGIPKS-----------------WAPDATSSSELNDPPV-QRESQ----
G-QVGLLAESAQGSLDAAQKQASSDENNTSQEAMMLEVT-------EGHEQLSKDQEQPP
QREQGSKVKGP--------------APA--------VEPQEHPEAHKST----G------
---EA--------E--------NNF------Q-EIEA---PGALD-------ADF---ID
QLS---------------------------------VTQLPVKK----------------
------ED-------------S---GKELKFQDPSSKEE----------------GGAPE
MQEAL-------------VK-----------------SLHEDSS-VSKLFQETESA----
------------------TSK---------------------------------------
-------------------------------QEKEQPLELVDADNDP-------------
----------------------------------QISAKKDH----------NTS-----
-------------------V---SQS---------------DL----KEKIQKGGE--RD
WRVER-------------------------------------ET---VYSN---------
PLY-TYLQEKIGQQADKTQEELQQ----KDQR-------GKESFP-----ES--------
---------------------CN---P----------L------GSSLTNDNQVSQQ---
ST----KELVPGGESADTEQTSDALQALAYEQSCPQ----------KE------------
-------TPALQ-------------------------------RKEHTTKQ---------
------------------------------------------------------------
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-------------

--------------------------MIDIFQQYSNNDKE-KDTLSKTELKELLEVELRA
VLKNPDD-----------EDIADVFMEMLDVDHNEKIDFT-----------E-YLL-M--
-V---------------L-K-L-A-K-A-Y-YES----TQK---K-RLQ---T-------
GSKRSR-SN-Y----------KGVEEDEEGDEG-RH----ASSHGRTDGK----------
----------G---------------------QSE-----------------------RS
SSPR-GRGKQRHG-SSSRNHERDT----STHRGKGK--HGKQHNT-TKKHR--G------
---------------------------ES---------NSS--ERRESRGKR-DRRSKER
S--------------------------DLEY-------------DTVRLENTKY-----R
EGWGKS-------------------CIKYY------------------------------
------------------------------------------------YEEQHGKGEERE
GKSNRQSSERKQSPDSTR-----------HSGSHQRSQSS-----QRHADSPRDSTRTS-
-----HRGKQE---SQAGQQSTDGPRHSTSSRGRHQEDS-----------------ASQA
SDSEAHS-----------------------------EVE-------------VGHRQTSS
--------THGRTTGSSSGVQRAASSR--------------------G--------QER-
DSTRHTGAHQSQASGQGR------------------------------------------
GHS---------------------------------------------------------
--------------------------------------ESGSRTREA-------QGSVGR
GQSAD--------H--SGHSAAGRT------Q-GQAT-----------------------
---------------------------------------STNQRN---------------
-------GG-SS----DSQGSD---SE---------------AHSEASEGQ---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------E-----
--------------------------------VGAHSHTRV--------SQRH-------
---------------QQRTSSRGQQG-----------SGA-----YHMYYY---------
E---DEHEH-----------EH-----------------EHDQ-A---------------
-------------Q-----SGHK-------------------------------------
----------------------EQQRS---------------------------------
------SGRAAQGTHQEQGRDSTRI-G-----G---------SHEGHSSSGR--------
------------------------------QAG---------------------------
-------SS--QGRVGTST----RERQG----S-SHREPARDSSEH---HKSRRGQEEH-
--------------------------HDGSRRSGSRQS--------Q-------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------VGSH------TGT--------------------
----------------DST-HAQAGHRGT-----ASRQPSGRE-----------------
-------QSPDSTRQSGS-H-------QRS--------------Q---------------
---SS-------------------------------------------------------
------------------QQHADSPRGSTRTSPRGRQ-----------------------
-------ESPAGQRSTEGARHATSNRARHQEDSTSQASDSEGHSEVSEGQEVGAH-----
----------GH--------------------------------------------TRVS
KRH--QQQTSSRGQHSSGAYHMYYYEDEHEHE----HQHQ---------H----DHAQSG
-HREQQ---------RSSGTASQGTRQEQGRDSTRIGGSHE-----------GHST----
---------------S-----------------------------------GRQTG----
-SSE---HRQSR-----R-------GXXX---------------XXXXXXXXX-------
----XXXX--------------------------XXX----------X-XXXXXXXXXXX
X-----------------------------------------------------------
------------------------------------XXGV-----PS---------RP--
--T----------------------------------------------------LDRWP
QAHC---------------------IQQ---------------------GQ-TP-----G
RQCQPGQ-----------------------------------------------------
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-------------

----------------MTDLLRSVVTVIDVFYKYTKQDEE-CGTLSKDELKELLEKEFRP
ILKNPDD-----------PDTVDVIMHMLDRDHDRRLDFT-----------E-FLL-M--
-V---------------F-K-L-A-L-A-C-NKV----LSK---E-YCK---A-------
SGSKKHRHGHQ----------HQEEESETEED--------EE-------DTPG-----RK
SGYRHSSWSEG-EEHGYS---SGGSRGTVKCRHGS-----------------------N-
-SRRLGRQG------------------------NLSSSGNQERSE-KRHHRSSS------
---------------------------GHSWS--------S--GKERHGSSS-GELGERI
N--------------------------KSHV-------------SPSR----ES-----G
EEYESE-------------------CG---------------------------------
--------------------------------------------SKSWGRKGHGGLSRGL
ETS--QH-----E-SNCT---------HDHPVFGHGQCIL-IHSHSESSSNRKQESHNDS
KR---------------------------------------------------------H
SEDWEKD---TH---E-------QLGSRHEKLDFS-TI----AIHGSSQQH---------
------------------------------------------------------------
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-------------

----------------MARLLKDVLCVIKTFHKYAQEDGD-KATLTCTELKLLIQGEFGD
ILQPRV------------IHAVERNLNLLDTDSSGTISFD-----------E-FVL-A--
-I---------------F-N-L-L-N-L-S-YLD----IQS-----LLK---S-EPRQ--
-VSNL-EE-KPDD------MDLQVTS---GT---------GQWTEQ---MPPT-------
-----------QDRA----------------VPPS----------------------GMT
SSAQFNPTER----------------GAVGHNGV----ENTKTCKLPVEEPGHNDP----
---KNQHL-------------------------------------------------EGD
-------QQSQEVAQDVSAMGDNGAQ-LETNK---TTAESEQTDSPTK-QEE-QDKESPM
EGD-KP----VRKQSIT------KTRDQC---------------EEQKGNLR--------
--------------------------------------------TQSSPPEKTTQRPSK-
-----------------DQ----------EVATEK-GVKE----------HSKTQELSL-
------P------------------GNYE-P-------------NSEPA---DLP-----
KQAAAQKPLQTE---KLTDPEDD--DRT----SVTQGQGEDAD------------RTPPE
------------TKN--PAEPGGDGR---------------------ASETQEPTAQE--
------------------------------------------------------------
------------------------------------------------------------
------------------KEQETKDLPVQGNNRNI----SETPDVR--------AIRKER
RGPEVHGTAEQ-EE--------------------NEI---------------------EI
QLLTL-------------EDQRQDGKY--QELQKSS-------KKRDAKAGSKT------
-----------------------------------------QESSSEGGVQN-----HPE
I--------------E-------RI----V-TPEEEARHAEEGTAKALMSSKNVPAAEGA
SGARE----------RTQE-----------------------------------------
--------------------------------------------LAPLKN-QSGEENKRV
TKTHDK--PVKDDDGYQ-----------------------------------EEDPEPTV
TQNNEGSSEIPNSLTPEDGDNSSETN---------------D------------------
--------LPVQGDSQ------------------NQGDPLRESV---------ERSHNGN
PDT---------------------------------------------------------
------------------------------------------------------------
---------------------------------------------EKQVALGEESRTEED
V------VLAVRV----------------------------E------------------
-EQDKQLTEEPEWATREEHR-S--------LGSG-----T-KGPGPAMYPNGHPEAQ---
---ESTTRG--EDRKSL--------EAD--FTDQFSIKQLPAKED---------------
-------------------SRRKLKVQGPSTKGEEGRTPETQDAPVKNLDEDNSASP---
--KTHLEREE-------PATL--EEDETPQELA-EANDQQNPAKK-RYDVSVPQTRLEEK
MQKNQEPSFVERGTVYSSPLYQYLKEKMLQQKEMTQM--------------------EQQ
N---------------------------------QAQTARSSSPE---------LLNNQS
SAPLTNEISDCPIIFSDSQAL----------------HYTKECLPDADPADAQQTSASLA
SEDKQSYPQEKKPVLQKEASTK----------------------------------E---
-----------------------------R------------------------------
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-------------

----------------MSALLESITSMIEIFQQYSTSDKE-EETLSKEELKELLEGQLQA
VLKNPDD-----------QDIAEVFMQMLDVDHDDKLDFA-----------E-YLL-L--
-V---------------L-K-L-A-K-A-Y-YEA----SKN---E-SFQ---T-------
HGSNGRSKTDY----------KGLEEEGEEGNK-QN--L-RRRHGGTDGK----------
-------------------------R---K---SD-----------------------RT
RSPN-GKRGKRQE-S--------------RCRSEGKDKHRR---E-PEKHRHQQ------
---------------------------DSKRKQRH-GSGST--ERKDNRN----KKNRQS
K--------------------------ERNY--------------DEIYDNGKY-----N
EDWEAS-------------------YNNCY------------------------------
------------------------------------------------YKTQNTTLDQRE
GNR-R------PRADSQK---------EPQSSHGQADNSD--------SEGGRQQSHSKP
SP--VRADQRRSRAGQAG--SSKVSARSGSGGRG------------------------QS
PDGSGRS---SN---RRD------------------RPRQ------------PSPSQSSD
------------SQV-HSGVQ-VEGRR--------------------GQSSS--------
-ANRRAGSSSGS------------------------------------------------
------------------------------------------------------------
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-------------

----------------MPQLLRNIHGIIEAFGRYAKTEGN-CMVLTRGELKRLLEHELAD
VIVKPHD-----------PVTVDEVLRLLDEDDTGTVEFK-----------E-FLV-L--
-V---------------F-K-V-A-Q-A-C-FKT----LSESP-EGVCG---S-----QE
SRSC-----HS-A----ASQELRE-GQRSHTEV--GGAGRGQLHEG--------------
-------SS-------------------------------------------------RG
QSKQA-----------STGQDG--------------------------------------
---------------------------SSTQVTHHDR------------------QAESQ
IQESM-SQEAQETGQTQ----SAEDKSHQTRE------G--------------Q-----S
ERQS-----QTREQDRAHQTSETV-TGTL-------------------------------
--------------------------------------------TQTQT--GATQTPGQD
RSHQTGSTGSQARESNYSQTRGT-------------------------------------
------HSQDRSQTSQ-----IVTGGHIQTQ-------------AGSQTQT---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---RSQTQTTEQDRSH----------------QTGNTSTQSWESTIGQTRGT--HSQNRS
Q---------------TSQGVT---GG--YV----------QTQTGSQTQTV--------
-----------------------------------------E------------------
------------------------------------------------------------
----------------------QDRSQMGSHVGARE------------------------
---------------------------------------------------QEQSQ----
TQSGSGQTWTQVGNYEA-GE----------------------------------------
---------TVLE-------------------------GQAQPGASTLTGNQDWSSSHPS
CSV----------TARQG-----------------------EGEPH-P------------
---KESNVVVEEWVDDPTREM---VVQRQNQSS----LHT--------------------
------------------SVSSAQGGETAQ------------PE-GRRGITTASG-----
----------L--------------------------YSYFKSNKP--------------
------------------------------------------------------------
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-------------

----------------MSTLLENIFAIINLFKQYSKKDKN-TDTLSKKELKELLEKEFRQ
ILKNPDD-----------PDTVDVFMDHLDIDHNKKIDFT-----------E-FLL-M--
-V---------------F-K-L-A-Q-A-Y-YES----TRK---E-NLP---I-------
SGHKHRKHSHH----------DKHEDNKEK-----------E-------NRKT-----PS
SLERRNNR-----KGNKG--RSKSPRETGGKRHES-----------------------S-
-SEKKERKG------------------------YSPT-QREEECR-KKHHKSSK------
--------------------------------------------KEKNKTEN-TRLEDNR
K--R-----------------------LSER-------------PEEK----ED-----K
EEGGYD-------------------YENTE------------------------------
------------------------------------------RMTEKLTESGQIATYYTI
QDE--AY-----D----T---------TDNLLEENKIYER-----SR-------------
------------------------------------------------------------
------------------------------------------------------------
-----------SSDD-ESSSQ-VNRSR--------------------HENTRQVPLHES-
RTRRHRG--SSVSQ----------------------------------------------
------------------------------------------------------------
-----------------------D--SE-GHSEDSERR-SGSASRNH-------HG----
--STW--------E--QSRDGSRHT------G-SHQE-----------------------
---------------------------------------D--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----RAGHGHSA------DSSRQSG-----------TRHTETSSRGQAAS---------
SYE---------------------------------------------------------
---------------------------------------------QARSSLGE-------
----------RH-GS-------RHQ-----------------------------------
-----------------QSANSSRH-S-----G---------IGHGEAS-----------
------------------------------------------------------------
-TAVSNHGH--QG---------------------SSGSQVSDSEGHSEDSDTQSVSA---
-------------------------------HGQA-------------------------
---------------------------GPRHQSHQ-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------ESVHGRS-----------------------
-------GERSGRSRSFLYQVSTHE---QS---------------------ESVHGRTRP
------------------------------------------------------------
-------------------------------------------------STGGRQGSHHE
QAQE-------------------------------------SS--WHSA-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------SQEGQDTIRGHPGSSRGGRQGS-------
HHEQQ----VDSSGHSGSHHSHNTSQGR-SD----------D-------------SRGKS
-GSRSA--SRQARNG-----EQ---------------------SG--------ED-----
----------SRHSGSRH------HEPSTQ---------------------------ADS
SRHSQVGQGESAGSRTSR---------------------------HQGSSVSQD------
SDS---------------------------------------------------------
------------------------------EGHSE-D-----------------------
-SERRS-----------GSA-----------S----------------------------
-----RNH------YGS----AWEQSRDGS------------------------------
----------------------------RNPGS---------------HQ----------
---------EDRASHR--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------LSADS-S
RQSDTRH-----------TE-------------------TSSHGQAASSQAHGRSSP---
----GERHGSR----------------------------PQ----QSADSSQHSGTG---
-------------------RRQASSAVR-------------------DSGHRGSS--GTQ
AS-------DSEGHSEDSDTQSVSAHGQAGSHQQGHQQ----------------------
------SAS-----GQS-GERSGR-------------SGS--------------------
----------------------F-------------------------------------
------------------------------------------------------------
--------------FYQVSTHEQSESAHGRNGPST------------RGRQGSRHEQA--
--RDSYRH--TASQ--EGQDT--------------IHEHPGSSRGG-RQGSHHEQSV---
-------------------------------------------------DSSEYSGSHHS
HTTSQGRAQASREQSGPRSASRQTRNEEQSGYGSRHSGSHNHEASTQAD------SSRHS
QVGQG--ESAGSRTRRHQGSSVSQDSDSGGHTEDSKR---------RSGS----------
------ASRNHRGSAQEQSRDGSRQPWSHHEDRAGHGHS------------AESSRQSGS
HHA---------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------ETSSRGQA
ASSHEQARSSP--GERHGSRHQQSADSSRH----SGI---RHGQAS-SAVRDSGHRG-SS
GNQASDSEG HSEDSDTQSV------SGHGQAGPHQQSHQESARGRSGERSGGSGSFRYQV
STHEQSESVHGRTGPSTGGRQGSRHEQAQDSSRHSASQEGQDT-----------------
-IRGHPGSSRGGQQGSHHEQSVDRSGHSESHHSHT---TSQGRSDASHGQSGSRSVSRQT
RN EEQS-------------------------------------------------GDGSR
HSASHHHDASAQANSSRHSQVGQGHSVGSRTSRHQGSSVSQDSDSE GRSEDSERWSGSAS
RN----------------------------------------------------------
------------------HHG-------S-AREQSRDGSRNPGSHQEDRAGHRHSAESPR
QSGT--------------------------------------------------------
------------------------------------PHAET-SSRGQAAS----------
--S QEQARSSPGERHGS-RHQQSADSSRHSGIGHRQASSAV----RHSGHRGSSGSQASD
SEG HSENSDTQSVSANGQAGPHHESHQESASGRSGERSGRSG------------------
----------------------SFLYQVSTHEQSESTHGRTGPSTGGRQGSRHEQARDSY
RHSASQEGQDTIREHPES--------------------------------------SRGG
RQGSHHEQSFDSSGHSGSQHSHTT-----------------------------SHGRSHA
SRGQSGSRSASRTTRN EEQSGDGSRHSGSRHYEAS-------------------------
TRADSSRHSQA--GQGQ----SQGSGTSRHQGSIVSQDSDSEG H--SEDSERRSGSA---
---S--RNHRGSAQEQSRDGSRQPWSHHEDRAGHGHS-----------------------
---AESSRQSGSHHAETSSRGQAASS HEQ-ARSSPGERHGSRHQQSADSSRHS-GIRHGQ
ASSAVRDSGHRGSSGNQASDSEG HSEDSDT-----------------------------Q
------SVSGHGQAGPHQQSHQESARGRSGER----------------------------
------------------------------------------------------------
--------------------------------------SGGSGSF------RYQVSTHEQ
SESVHGRTGPSTGGRQGSRHERARDSSRYSAS---QESQ----DTIRGHPGSSRGGQQGS
HHEQSVDRSGHSESHRSHTTS---------------------------------------
----------------------------------QGRSDASHGQSGSRSASRQTRNK EQS
GDSSRHSASHHHDASARANSSRHSQVGQGHSVGSRTSRHQGSSVSQDSDSE GRSEDSERW
SGSASRNHRG-----S-AQEQSRDGSR---------------------------------
-----------------------------------------NPGSHQEDRAG--------
--------------HRHSADSSRRSGTPHAETSSRGQAVSS QEQARSSPG----ER---H
RSNHQ-PSAD-------SSRHSGTGHGQ--------------------------------
-----ASSAVSDRGHQLSSGSQASDSEGHSE-DSDTESVSAHAQAGPHLQSHQESAHGRS
GQQSGHSGSFLYQVSTHEQSESAHGWTGSSTGGTRGSRHEQARDSSRHSASHEGQVTIRE
H-------TGSSREGRQGSHHEQSVDS---------------------------------
---------------------------------------------SGYSGSHH-------
----------------------SHNTSQGRSQASRGQSG----SRSASRQTRDEEQIGDG
SRHSGSRHHEASTQANSS---RHSQSSQGE-----------------------SVGS---
-------RRSRHQGSSVSQDSDSE------------------------------------
------------------------------------------------G-HSEDSERRSE
--------SASRNHHGSSREQSRDAPRHP-------GSYPRDTASHV--------QSSSI
QSDSSTT---------------------------------------------KE------
----HGHFSSLSQDS--------------------AYRSGIQS-----------------
RGSP--------------------------------------------------------
--HRSSSY-----------------DYQSEGTERQKGQSGLVWRHGSYGS----------
----------------------------------------ADYDYGESGLRHSQH-----
------RSVSYNSNPVVFKK---------RSDICKASSFG-------------KD--HPR
YYATYLNKDPGLYGHSSDISKQLGFSQSQRYYYYE-------------------------
------------------------------------------------------------
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-------------

----------------MPQLLRNINGIIEAFRRYARTEGS-CTALTRGELKRLLEQEFAD
VIVKPHD-----------PATVDEVLRLLDEDHTGTVEFK-----------E-FLV-L--
-V---------------F-K-V-A-Q-A-C-FKT----LSESP-EGACS---S-----QE
SGSL-----HS-G----AWQELSE-GQRSGTEV--GRAGKGQHYEG--------------
-------SS-------------------------------------------------HG
QSKQP-----------SRGQSR---------------PGAQTQG----------------
------------------------QATGSAWVSSYDR------------------QAESQ
SQERT-SPQIQCSGHTEQTQRAGEGKRHQTTQ------M--------------R-----P
EREP-----QTREQDRAHQTSETV-TGSG-------------------------------
--------------------------------------------TQTQA--GATQTVEQD
SSHQTGSTSTQTQGSTNGQNSGT----------------E--------------------
-----IHGQGRSQTSQ-----AVT-GHAQIQ-------------A---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------GTHT-----------------------------------------------
------------------------------------------------------------
---QTPTQTVEQDSGH----------------QTESTSTQTQGSTNGQNRGTEIQGQGGS
Q---------------TSQAVA---GG--HA----------QTQAGSHTQTV--------
-----------------------------------------E------------------
------------------------------------------------------------
----------------------QDRSQTVSHGGAGE------------------------
---------------------------------------------------QGQTQ----
TQPGSGQKWTQVSNPEA-GE----------------------------------------
---------TVPG-------------------------GQAQTGASTESGRQEWSSTHPR
HNV----------TEGQG-----------------------DIQPT--------------
-------VVGEEWVDDHSRET---AIFRLDQGN----LHT--------------------
------------------SVSSAQGQDAAQ------------PE-EKQGIT-ARE-----
----------L--------------------------YSYLRSNKP--------------
------------------------------------------------------------
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-------------

----------------MAQLLSSILSVIEVFHKYAKENGD-CTLLCKEELKQLLLAEFGD
ILQRPND-----------PETVETILNLLDQDRDGHVDFH-----------E-YLL-L--
-V---------------F-Q-L-V-Q-A-C-YRK----LDN---K-SYG---G-------
RTSQ-QERGQE-R-----AQDHKFPGN-TGT---QH----RQRHKEERQ-----------
-NSHHSHQPERQDRD---------------SH--------------------------HG
QPERQDRDS--QH-SQPERQDRDSPHSQP---------------ERQDRDSHNGQPKRQD
RDSHHSQPERQ------------DRDSHHGQDSHHGQPER---QDRDSHHNQ--GQTKWQ
G--HI-------F-------------ALNGCE------KP------VQ-----------D
SHYGQ-------------------------------------------------------
---------------AE---------------------------RLAQ-Q----------
------------------------------------------------------------
----------------------C-----ETFGQDSRFNRTNQQKSGSYC---GQSGRLGQ
ELGCGQTDRQDQQGQSSHYGQTNRQG-Q--C------Y-----------HYGQTDRQGQS
-------------------S--HYS-------------------------------QP--
---DR----QGQSSHYGQPDRQG-------------------------------------
------------------------------------------------------------
-----------------------------------------------QSSH---------
------YGQTDRQG---QSFHYSQTDRQGQSSHY-GQTDRQGQSSHYGQ---P-------
-------------------------------------------------DR---------
------QSQSSH----YGQTNR--QDQSSH-----YGQTDRQSQSSHYGQTDRQDQSSH-
------------------------------------------------------------
------------------------------------------------------------
-------------------YGQMDRQGQSSHYSQTDR-----------------------
-----------Q------------------------------------------------
---------G--------------------------------------------------
-----------------------------QSSHYSQMDRQGQSSHYGQTDRQGQSSHYSQ
PDR-QGQSS------------HYGQTDR--------------------------------
----------------QGQS-----------------SHYSQTDRQGQSSHYGQTDRQSQ
SPHY--GQTDRQGQSFHYGQTDRQGQSSHYGQTDRQGQSSHYGQTNRQGHSH--------
----------YG-------------------------QTDRQRTEG-TR-----------
--K-ASYVEQSGRSGRLSQQTPGQEEY-QNQGQGFQSRDSQENSHQVWEP----EEDSQ-
-----------HHQHKLLAHI--QQERP--LCHKGRDWQSCSN-----------------
-------------------EQGHRQAKTRQSHGE--------------------------
------------------------------------------------------------
--------------------------G---------------------------------
------------------------------------------------------------
----QSHWA------EEEQGHQ-----------------SWDRHSHEGQKGPCGTQDRQT
PEDEQNHERRDRQTPEDEQNHQ--------------------------------------
--RQDRQIHEDEQNH-Q-------------------------RRDRQTHEDEQNHQR---
------------------------------------------------------------
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-------------

----------------MTNLLRSVVTVIDVFYTYTKQDGE-CGTLSKDELKDLLEKEFRP
ILK KPDD-----------PD TVDVIMHMLDRDHDRRLDFT-----------E-FLL-M--
-V---------------F-K-L-A-M-A-C-NKV----LGK---E-YCK---A-------
SGSKKHKRGRQ----------IQEQESETDEE---------E-------ETSG-----PK
SGYRYPSV-SG-EEHGYR---SEGSRSNVRHKRGS-----------------------V-
-SRRLGRRG------------------------GLSSSDSQDGSE-KRHCRSSS------
---------------------------DHSWS--------S--SRERFGSSS-RELRERR
N--------------------------KSYA-------------SPTG----GS-----W
EDYESV-------------------S----------------------------------
---------------------------------------------RKRGRKGNDGLSHGL
EAD--GH-----E-VDTT---------QSRKYGGSKPDS-----SSKGSGDSGRQSHACV
SS---------------------------------------------------------S
SSGCGRP---NN---SSCSCKER----QENQSHCT-QSGFQSGNSGGEGYGYTSGSQSYG
NSQ-----CGPSSCR-NSCSQRRSEA----------------------RACCQ--PQNC-
GEQQQIG--SSQFSCCGQY-----------------------------------------
-----------------------------------------------G-------S----
-GRNQSSSCNQY-----------GSCSC-GQSSNTQQNVSGTN-----------------
---AC--------C--QHAYGSSQS------T-SS-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------RQGSGSGQSSGIGQHG-----------YGSSQFSGSSKQGS---------
GSS---------------------------------------------------------
---------------QYSDSSQH---G----------S------GSGKSDGKQ-------
----------GS-EP-------RQS-----------------------------------
-----------------X-----XX-X-----X---------XXXXXXX-----------
------------------------------------------------------------
-XXXXXXXX--XX---------------------XXXXX--------------XXXX---
-------------------------------XXXX-------------------------
---------------------------XXXXXXXX-----XX------------------
------------------XXXXXXX-----------------------------------
------------------------XXXXXXX------XXXXXX-----------------
--------------------XX----------------XXXXX-----------------
-------XXX-XXXXXX-------------------------------------------
------------------------------------------------------------
----------------XXXXXXXXXXXXXXXXXXXXX-----------------------
-------XXXXXXXXXXXXXXXXXXXXXXXXX---------XXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXX-------------------XX--------------
XXX--XXXXXX------XXXXXXXXXXXXXXX----XXXX---------XXXXXXXXXXX
XXXXXXXXX-XXX-XXXXX-XXXXXXXXXXX--XXXXXXXXXX--XXXXXXXXXXX----
---------------XX----------X----X-X-------------------------
------------------------------------------------------------
-------X--------------------------XXXXXX-------XXX-XXXXXX---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------XXXX--------XXXXXXXXXX--XXXXX------
-------XXX------------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--------XX-----
----------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXXXXX------
XXXXXXXXXXXXXXX--------XXXXXX---XXXXX------------------X----
----------XXXXXXXXXXX---------XXXXXXX-----------------------
-XXXXX-----------XXX-----------XXXXXXX----------------------
-XXXXXXX------XXX----XXXXX---X------------------------------
----------------------------XXXXX---------------XXXX-------X
X------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-------XXXXXXXXX-------
--------------------X--XXX---------------------------------X
--XX------------XXXXXX------X--------X----------------------
--XX---------XXXXXXXXXXXXXXXXXXXXXXXXXX-X---------XXXXXXXX-X
XXXXXXX-----------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXX-X
XXXXXXXXXXXXXX--XXXXXXXXXXX------------XXXX--XXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXX--------XXX-XXXXXXXX--XXX
XXXXXXXXXXXXXXXXXXXXXXXXX---XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXX-----XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXSGSPQGQRGSQ
HGEASSGVT-------GRQGVPHRQSEDTTRHTHSSHEQTTHSRASP--RRGST-----H
SEAS--DAEGHSGISQRHPYHGQSGSQHPESRSSVR------------GRQGSQHAQAR-
-----------------------------DGTRQTHSTHGQTTHTQRARGSTQSESSDTE
AQAEIPQ----RHSGSPQGQRGSQHGEASSR-----------------------------
------------------VTGRQGVPHRQS-----------------------EDTTRHT
HSSHEQTTH--SRASPRRGSTHSEASDAEGHSGISQR---------HPAT--TQGQSGSQ
HPESRSSVRGRQGSQHAQARDGTRQTHSTHGQTTHTQR----RRGSTQSESSDTEAQAGI
PQRHSGSPQGQRGSQHGEASSRVTGRQGVPHRQSEDTTRHTHSSHEQTTHSRASPR--RG
STHSEASDAEGHSGISQRHPNTTQG-----------QSGSQHPESRTSVRG--RQGSQHA
QARDGTRQTHSTHGQTTH------TQRARGST-QSESSDTEAQAGIPQRHS--GSPQGQR
GSQHGEASS--RVTGRQGVPHRQSEDTTRH----THS---SHEQTTHS--RASPRRG-ST
HSEASDAEGHS-----------------------------------------GISQRHPA
TTQGQSGSQHPESRSSVRGRQGSQHAQARDGTRQT---------------------HSTH
GQTTH----TAGRRGSTQSESSDTEAQAGIPQRHS--GSPQGQRGSQHGEASSRVTGRQG
VPHRQS-------------------------------------------------EDTTR
HTHSSH------------EQT-----THSRASPRRGSTHSEASDAEGHSGISQRHPATTQ
GQSGSQHPESRSSVRDRQGSQHAEVGDASRQTHSTHAQ-------------NTHLRGRRG
STQSESSDTDGHAGISQRHSG-----F-PLSQHGSQHGEAGSRVTGRQGTHHGQSGLTTR
HTHS----SHGHTTYSGFKVG--RVRVPTAHNHSQIHRRSRSSSNEGWRHGSYGSADYDY
GQYGFRPSGGSQTSSRNPSPFRSADTSTNKHVRRHA------------------------
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-----------------SPLLRSICDITEIFNQYVSHDCD-GAALTKKDLKNLLEREFGA
VLRRPHD-----------PKTVDLILELLDRDRNGRVDFN-----------E-F-L-L-F
-V---------------F-K-V-A-Q-A-C-Y--Y-A-L-G-Q-A-TG--L-D------E
E-KRA-R-C-D-G-K-E-SL-L--QD-RSKEED-Q-R-----------------------
-------------------------------RF-------------------------ES
RDRQLEEEPG-----QRRRQKRQE----QER--EL-AEG-EEQSEKQE-RLQQRDR----
--------------QRR---------DEELWR------------------Q-RREWKEQE
E--R----------------RAEEEQ-LQRCK-------------------GHETEAFPD
EE-QQR----RRELQ---------------------E---LRRERREEKQQQRR------
-------------E------------------R--QERVLQEEEEKEW-RKRERVHRQEE
-----------------------------KLQEEK-LQEE-------------E--PQL-
-----QRELQE-EEEQL--------QKLERQ---------------------ELKREGQA
EE----Q--QQQ---RLRREREERREQQ--L-RRKQEEER--------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------REQEERREQ--RL
KREQEERREQQE-----------RREQW--------LKREEEEERRE-------------
-----------------------ER------L-KSEQEEERR-EH------WL-----KR
EE-EE-KRREQERREQRLKRQEEEERR-EQ-LLKREEERLQQERR-------------EQ
W--LKREQ-------------E---ERREQRLKREQEEERRDQL------LKREEEEKRR
QQEERREQRLKRQEEE--------ERREE------E------------------------
---------------------------QRLEQEERREQR----------LKREQEERREQ
LLKREEEE-ERREQLLKREEEEEERLEQEERR--EQRLKR-EQ-------EE--------
----------RREQRLKREEEERLEQEKR-R-E-QLE-ERRQ-QWLRR----EQEL----
---------------A--EE---EQE---------------QA-----RERIKSQTPKWQ
WQLENE-------------------------------ADARQSK---VYSR---------
PRK-QEGQ-----RRRQEQEEKRR------------------------------------
-------------------RRER---E----------L---------QW---Q-------
----------EEEQARRQQQEEEQRRDFTWQWQAEE-----ERQRGRQRLS---------
-----A-RPSLREQRERQLRAEER----------QQREQRFLQEEEEKEQRRR--QRRE-
RERELQFLEEEEQLQRRERAQQVQEEGYGPQEDQERRRSPEQRRDQKWRWQ--LEEER--
-K---------RRHYTVYA-------KP------ALRGQLRKEQQ----L-----QQQE-
------E-EELQ--REE-REKRRRQEQERQYREE-EQL-QQEEEQLLREE----------
-REKRR-RQERERQYREDQKL-QQEEEQLLG--------------EE-------------
---------REKRRR-RERERQYRKEEELQQ-------------------------EEEQ
LLR---------EE-REKRRRQEQEREYREEEELQQEEEQLLREERE---------KRSL
-QERERQYRKEEELQQEEE--QLLREEREKRRLERERQ-YREEEELQQEEK-QLLREE--
-REKRRRQELERQYREEEELQQEEEQLLRE--------------E---------REK-KR
RQERERQYRKE-ELQQEEEQLL-------REEREK----RRLERERQ-------------
------------------------------------------------------------
------------------YREEEEL---QQEEKQL---LREE------------------
------------------------------------REKRRRQELERQYREEEELQ----
--Q-------------------------------EEEQLL---RE--EQEK-RRQEPERQ
Y-----------------------------PEEEELQHQERKRRYRDEDQRRDLKW----
QWEPEKENAVRNNRVYCKRRENE-QFRQLED-SQVRDRQSQQDLQPLLDEPQ------ER
GGEQEKRRWQQRDRHFPEEEQ----LERE--EQKE-AKRRDRKFQEEKQLVRR-G-----
----RDRKFQQQ------------------------------------------------
LR---------HDQRDRKFLEE---------EQE--------------------------
------------------------------------------------------------
------------------------------EQQLRRQ---------------EQRDRKFL
EEEQ--------QLRRQERDRKFRE-----------------------------------
----------------------EEQQLRPQ------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------ELERKFLQE
EQQLRRQELER--------------------K------------------FQTEEEQ---
---------------------LRRQEQQ--------------------------------
------------------QLRRQERDRKFREEEQQL------------------------
----RQEREE---------QQLRRQERDRKFREEE--------QQLRR------------
------------------------QERDRKFLAELQ--------------------LRRQ
E---RE-Q-QLRQDRDRKFREEEQLLQER--EEQQLRRQERDRKFRE-------------
------------------------------------------------------------
---EEQ--------Q-LRRQEL------ERKFREEEQLRQETEEEQLHRQERDR------
--KFLEEEQLRQEREE-Q-QLRRQERDR-KFREEEQLRQEREE-------QQLRRQER-D
RKFREEEQLPQEREEQ--QLRRQDRDRKYRWEEEQLQL----KKQE--------------
------------------------------------EQRLRQE-----RDGQYRAEE---
-----------QFATQEKSRRQAQELWQEEEQKRRQERERKLREEH-LRSQQEEEQRRR-
-----Q----V------RET--------QSQEGKGHGRLLE-----PGSHQFASVPV---
-------------------RSSPLYEYIQEQRSQYRP-----------------------
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----------------MAQLLSSILSVIKVFHKYAKENGD-CALLCKEELKQLLLAEFGD
ILQRPND-----------PETVETILNLLDQDRDGHVDFH-----------E-YLL-L--
-V---------------F-Q-L-V-Q-A-C-YRK----LDN---K-SYG---G-------
RTSQ-QERGQE-G-----AQDRKFPGN-TGT---QH----RQRHEEER------------
-DSHHG-QPERQDRD---------------SH--------------------------HG
QPERQDRDS--HH-GQPERQDRDSHHGQP---------------ERQDRDSHHNQSERQD
KDFSFDQSERQ------------SQDSSSG------SGKK---VSHK--STR--GQTKWQ
G--HI-------F-------------ALNGCE------KP------VQ-----------D
SHYGQ-------------------------------------------------------
---------------SE---------------------------RLAQ-Q----------
------------------------------------------------------------
----------------------P-----ETFGQDSHFNRTNQQKSGSYC---GQSGRLGQ
ELGCGQMDRQD---QSYHYGQTDRQD-Q--S------S-----------HYGQMDRQGQS
-------------------S--HYS-------------------------------QT--
---ER----QGQSSHYSQTDRQG-------------------------------------
------------------------------------------------------------
-----------------------------------------------QSSH---------
------YNQMDRQG---QCYQYGQTDRQGQSSHY-SQPDRQGQSFHYGQ---T---D-R-
---------------------------------------QGQSSHYGQTDR---------
------QGQSSH----YGQTDR--QGQSSH-----YSQMDRQGQSSHYGQTDRQGQSSH-
------------------------------------------------------------
------------------------------------------------------------
-------------------YGQTDRQSQSPHYGQTDR-----------------------
-----------Q------------------------------------------------
---------S--------------------------------------------------
---------------------------QS--PHYSQTNRQGPSSHYGQTDRQGQSSHYGQ
TDR-QSQSP------------HYGQTNR--------------------------------
----------------QGQS-----------------SHYGQTDRQGQSSHYGQTDRQGQ
SSHY--SQMDRQGQSYHYGQTDRQGQSSHCGQTDRQSQSYHYGQTDRQGQSS--------
----------CYVQSQT---------G---EI--QGQNKYFQGTEG-TR-----------
--K-ASYVEQSGRSGRLSQQTPGQKGY-QNQGQGFQSRDSQENIHQVWEP----EEDSQ-
-----------HHQHKLLAHI--QQERP--LCHKGRDWQSCSN-----------------
-------------------EQGHRQAKTRQSHGE--------------------------
------------------------------------------------------------
--------------------------G---------------------------------
------------------------------------------------------------
----QSHWA------EEEQGHQ-----------------SWDRHSHEGQEGPCGTQDRQT
PEDEQNHQRRDRQTHEDEPNHQ--------------------------------------
--RQDRQTHEDEQNC-Q-------------------------RRDRQTYEDEQNHQR---
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----------------MAQLLNSILSVIDVFYKYAKGNGD-CALLCKEELKQLLLAEFGD
ILRRPNN-----------PETVETILNLLDQDRDGHVDFH-----------E-YLL-L--
-V---------------F-Q-L-V-Q-A-C-YRK----LDN---K-SHG---G-------
RTSQ-QERGQE-G-----AQDRKFPGN-TGR---QH----RQRHEEERQ-----------
-NSHHS-QPERQDGD---------------SH--------------------------HG
QPERQDRDS--HH-GQSEKQDRDSHHGQP---------------ERQDRDSHHNQSERRD
KDFSFDQSERQ------------SQDPS--------SGKK---VSHK--STS--GQAKWQ
G--HV-------F-------------ALNRCG------KP------VQ-----------D
SHYGQ-------------------------------------------------------
---------------SE---------------------------RLAQ-Q----------
------------------------------------------------------------
----------------------S-----ETLGQASRFNQTNQQKSGSYC---GQSERLGQ
ELGCGQTDRQG---QSSHYGQMDRQD-Q--S------Y-----------HYDQTDRQGQS
-------------------S--HYS-------------------------------QT--
---DR----QGQSSHYS-------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
-----------------------------------------------QPDRQGQSSHYGQ
TDR-QDQSY------------HYGHPGG--------------------------------
----------------QGQS-----------------SHYGQMDRQGQSSHYGQMDRQGQ
SSHY--GQTDRQGQSSHYGQTDRQGQSSHYGQTDRQGQSYHYGQTDRQGQSS--------
----------HYIQSQT---------G---EI--QGQNKYFQGTKG-TR-----------
--K-ASYVEQSGRLGRLSQQTPGQEGY-QNQGQGFQSRDSQQNSHQVWEP----EEDSQ-
-----------HHQHKLLAQI--QQERP--LCHKGRDWQSCSS-----------------
-------------------EQGHRQAQTRQSHGE--------------------------
------------------------------------------------------------
--------------------------G---------------------------------
------------------------------------------------------------
----LSHWA------EEEQGHQ-----------------SWDRHSHEGQEGPCGTQDRRT
HEDEQNHQRRDRQTHEDEQSRQ--------------------------------------
--RRDRQTHEDEQNH-Q-------------------------RRDRQTYEDEQTHQRR--
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-------------

----------------MSPLIRSIVDITEVFNQYASQSCD-GASLSKKDLKNLLERELGD
VLQSPHD-----------PETVDLTLELLDRDCNGRVDFN-----------E-F-L-L-F
-L---------------F-K-I-A-Q-A-C-Y--Y-A-L-D-Q-A--A--E-L------G
E-KRA-L-P-S-E-K-R-NL-S--QD-RRK-ED-Q-R-----------------------
-------------------------------RF-------------------------EP
RGRQLDEEPG-----SRSWQKRRE----QE---RA-EEQRLE----------QRHR----
-------------QHRE-----------EQ-R------------------LQRRELQELE
E--R------------------------------------LAEKEPLSWSKGRDAEEFSE
VEEQQS----QERQE-------LKGKGQTEER----------------------------
--------------------------------------RLQKR------RQEE-------
------------------------------------L--R-------------E--PLL-
-----R------------------------------------------------------
------------------------------------------------------------
--------------------------RDLELRREQEL-----------------------
-----------------------------------------RRE--------QELR----
---QELRREQ---ELRREQ---------ELRQELRREQELNRRQELRREQELRR------
--EQEL-------------------------------------------------RQELR
REQE--------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
LRQELRREQELRREQE----------------------LRQE------LRREQELRREQ-
------------------------------------------------------------
------------------------ELRQELRREXXXXRRE-QELRQE-------------
---------------LRRE----------QE-L-RRE-QELR-QELRREQELRQELA---
---------------EE--E---EQT---------------RI-----REPDQSITQRWQ
WQLEDE-------------------------------AEARQNK---VYSR---------
PSR-QEQR-----LRQELEERQL-------------------------------------
------------------------------------------------------------
-----------------------QRRDLQQQRPAEE-----ARQRN--------------
-------------QWERSQRAEER----------LEQEQRFRDREEQR------------
------FR--EEKLQRAELQDS------LLE--EEQRRLQEERRE-----------AS--
-----------QRRRTLYA-------KP------SQRQRREEELR-EERL-----LQEE-
--------------------QRLQR--ERKSHR---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------EEDLQQEE------------------------------------
-------------------------ERLQQDEEQ--------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------LQRERRRLQRERQYQEEDLQQEEER
LQQ-------------------------------EEERLQ---RE------RRRLQQERQ
Y------------------------------------QEEDLQRLRDEDQRRDLKW----
QWQPRKESEVRSNRLFTKRRGDEETIQQLED-SRER--VRRQDRRPLQAEEE-----EKK
ELEQERRRRQQRDRQILEEEQ----FQREH---QREARRQDETFQEEEQLQGE-SR---R
RQQEREGKFLEEERQLRTERE-----------------------EQRRRQEQEREFQEE-
EER---------------------------------LQELEKELRQECDRKSREEQELRQ
QRE------------------EEQLRRQERDQRFRREQERRLERE-----EEQLRDRPSR
REQERRLEREEEQLRDRPSRRXQERRLEREEEQLR--------------------DRPXR
REQERRLER----EEEQ-------------------------------------------
------LRDR--------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----PSRRE--------------------------------------------------
-----------------------QERRL-----EREEEQLRDRPSRREQELRRDRKFREE
EERREELEE-----EQRGQERDP-------------------------------------
--------------LRVEEQLRGQREEEQRRRQECDRKLHREQEVRQELEEER-----LR
DSKIRREQELRRDQ-------------------------------ELR-----REREEER
LRDSKIRRE---------------------------------------------------
------------------------------------------------------------
----------------QELRRDQELRQGL--EEEQLRRQERDRKFRTG------------
-----GRAAEAPGTKFREEQELGQELEEERLRDRKIRREQELRRE------REQEQRRRL
EREEEQQRLQEREEEQRRRQERE-QEQQRCLEREEEQFR--FEEQQRRRQEREQQLRQER
DRRVLEEEELRQEREE---LLHRQVGG-RKFREEERLRLEREE-------QQRRLQERDN
RRFREEVELRQEREGQQLRQ---ERDRKFREVEELRL-----------------------
---------EEEQRRRQERDRKFREEKHLR-----EEQQL----RREKRDGQYLAEE---
-----------QFARDTIRRQ-EQELRQDEEQRRRQERERKFQEEQ-IRR----------
-----------------------------RQEEQRRRQILE-----PGTRQFANVPV---
-------------------RSSPLYEYIQEQRSQYRP-----------------------
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-------------

Query Results

"ENSGT00530000063634"

ENSGT00530000063634