Query Results 

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------MKRKTLQRATPTL--WRPHMASIW-
----TWTSSKISPSTSLKSIMKKKDYGFRAGGN--GTKKNLQFVGVNGG-----------
YETTSSE-ETSGEDSSP----EDLSDSEAEKKCDGPEPRR--GKDAHLSCRVGQGTPEGT
-----RDTDQETGPGE-----ELPHPKTERYKPSEEFLNACRVL-SQHLPETG---TTTD
QLLKQSLNTISQEWFRISSRKSSSPAVVA-SYLHGVQPHSPHLLKLLVNLADG

PF00023 // ENSGT00530000063448_2_Domain_1 (1014, 1040)

NGNTALH
YSVSHSNFSIVKLLLETGVCNVDHQNK--AGYTAVMITPLASAETDEDMAVVWKLLREGN
V--NIQATQG

PF00023 // ENSGT00530000063448_2_Domain_3 (1091, 1121)

GQTALMLGVSHDRGDMVQALLSCQADVNLQ

ENSGT00530000063448_2_Linker_3_4 (1121, 1123)

DH

PF00023 // ENSGT00530000063448_2_Domain_4 (1123, 1148)

DGSSALMLACCHGNTDMV
RLLLAHPTCDSSLTDKAGQTALSIALKSP---AHVEIAGLLRAHLKQGRSLGP------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------MITPLASAETTEDLAVVWQLLQEGN
V--NIQATQGGQTALMLGVSHDRGD

PF12796 // ENSGT00530000063448_2_Domain_4 (1106, 1183)

MVRALLRCRADINLQDHEGATALMLACRHGNADLV
RLLLAQPSCDSSLADKAGHTALSIALQSP---GHAEIAGLLRAHAEQGGLAQ-------

-------------------------------------------MEKTDA-KDQSSQGD-E
EKDPPKSHPYSVETPYGFHLDLDFLKYVDDIEKGHTIKRIPIHRRAKQAKFSTLPRNFSL
PDSGARPHAALP-HQNWFPVVP--------RKVSLGAEERAQSLPP-GGPQA---SASGS
EVSYHRKALLGETARQLEAA-DPGSDELSSGYGRPQLLRASSMPATLLQNRAS-EDPNLN
SGPPTSPALPPLESEDSVSD--GTFGPAEGFAG-FHNSSPRAA----------------T
RI----PELVREGTKPPEA--------E--EEAPHHLSLPSPPFSSQNALVVLEDAEDEH
ETREAEV---VVTSGLPTPSPPPLPSPIPENELPLEE--LIISEIPPP-PPVEVDVRSIG
--IRVTEESLG---------LATMDPGSISSLKQQLSDLEGELSGRTEELAHVRAALQQQ
EEEIKARGQRIQELECTVAQLAEKLSHENTKDAQ----------GQIDAMVNTDPLH-GL
LTRELCDKSIGVNLLSSMGSESWGARGEKNGFLCGQDSHKQRDQSPAELVPPP-QLSLPQ
GPEMI--LTSSLHSCLSTELRI--EEAGSEPE-GD--SQLGAEGPVRGAGSSSWSSD---
-------IKAPQAGKEE-ASSELPGRECPGRPPSSPT-DASIGQYVK--KIQEL-LQEQW
-SCL-EHGYPELASAIKQPASKLSSIQRQLLSSLNLLLSAYSAQTPPQ--RES--PAAS-
----SPPPVEMSPSASLKSIMKKKDYGFRAGGN--GTKKNLQFVGVNGG-----------
YETTSSE-ETSGEDSSP----EDLSDNEAEKKCDGPEHRR--GKDAHPSCKVGQGIAEGT
-----RDTGQECGPRE-----ELPLPKPDRYKPSEEFLNACRAL-SQHLPETG---TTTD
QLLRQSLNTISQEWFRVSSRKSSSPAVVA-AYL---QPHSPHFLRLLVNLADG

PF00023 // ENSGT00530000063448_2_Domain_1 (1014, 1047)

NGNTALH
YSVSHSNFSIVKLLLETGVCNVNHQNK--AGYTAVMITPLASAETDEDMAVVWKLLKEGD
V--NIQATQ

PF00023 // ENSGT00530000063448_2_Domain_3 (1090, 1122)

GGQTALMLGVSHDREDMVQALLSCQADVNLQD

ENSGT00530000063448_2_Linker_3_4 (1122, 1123)

H

PF00023 // ENSGT00530000063448_2_Domain_4 (1123, 1155)

DGSSALMLACRHGNADMV
RLLLAHPACDSSLTDKAGRTALSIVLKSP---AHVEIAGLLRAHAEQGRSLGP------

-------------------------------------------MEKTDARDQPSSQGD-G
EKEPPQSHPYSVETPYGFHLDLDFLKYVDDIEKGHTMKRIPIRRKTKQPKFSTLPRNFSL
PDSGARPHAAPS-HPTWTSSF--------PGLPTKGAEE------PPSDSAQP--LAAGG
EISYRRRVLLAETIRQVEAT-PPMEAEPDGGRGRPQLLRASSMPVTLLQHKVS-DEPSLS
FTLPEPPPLPQPPDDGGFPD--GAFGPSEGFSD-PHSSSLQAFTQ---------------
-I----PDLVQDGPEHPDQD----------KELQNHSCLLSQPSLPQDLPVVLESTEEEL
KVPEVEL---VATPGTPTPSPPPLPSPIPENEFPL-EIELNISEIPPP-PPVEMDVRSIG
--IRVTEESLGLARAGAD---------SVSALKQQIAILEGELSKRTEELEKVMVALQQQ
GDEMRNKELSIQELMGTVAQLEKQLSQRNAHDTC---------HD---AAVNTDP-----
-GSEAYDERVLLNLPVIM---------SQPPGHP-----WQRSAL----------QLPPQ
EPEAF--ARKPKHSYLSTELKI--EEPDPEQ-EGT--EAP-A------------------
---------------RGLAGSSSP----GTEQRSPPP-DITIGQY-VK-KIQEL-LHEQW
T-CL-EHGYPELANAIKQPASKLSSIQSQLVNSLNLLLSAYSAQSPPEQE---------L
PAD---PPPEISPSTSLKSIMKKRDYGFRAGGN--GTKKNLQFVGVNGG-----------
YETTSSE-ETSGEDSAS----EGCSDSEVDKKGDGP--EHKLGKTAEQNQQTVPDTEEGT
-----GSMGLESRPVGEA-VTADTHHKSEXXXXXXXXXXXXXXXXXXXXXXX-X-XX--X
XXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXLKLLVNLADD

PF00023 // ENSGT00530000063448_2_Domain_1 (1014, 1047)

NGNTALH
YSVSHSNFPIVKLLLDTGVCDVDHQNK--AGYTAVMITPLASAETDEDMDVVWKLLKQGN
V--NIQAAQ

PF00023 // ENSGT00530000063448_2_Domain_3 (1090, 1122)

GGQTALMLGVSHDRGDMVKALLTCRADINLQD

ENSGT00530000063448_2_Linker_3_4 (1122, 1123)

N

PF00023 // ENSGT00530000063448_2_Domain_4 (1123, 1155)

DGTTALMVAARHGNTDMV
KLLLAHPSCDATLTDKAGHTALSMALTSP---AHGEIADLLWAHAEQGRSPGP------

-------------------------------------------MEKTDA-KDPSSQGD-E
EKGPPKSH

PF12075 // ENSGT00530000063448_2_Domain_0 (69, 107)

PYSVETPYGFHLDLDFLKYVDDIEKGNTIRRIPIHRRA

ENSGT00530000063448_2_Linker_0_1 (107, 1014)

KQAKFSTLPRNFSL
PDSRARPHAALP-HQNWSLAVP--------RKVSLGTEERAQSLPL-GEHPQA--SASGS
EVSYHRKALLAETARHLEAA-CAREAELAPGGGRPQLLRASSMPATLLQNRAS-EDSSLN
SGPPTPPALPPLQGEGSVCD--GAFGPAEAFTG-FQSSTPRATTQPRVREFGDL----VP
GI----PELVQEGTEPPED--------EDEEEAPNHLSLPSPPFSSQDALVVLEDEDDEH
KTREAEV---VATPGSPTPSPPPLPSPIPENEFPLEEIELNISEIPPP-PPVEIDVRSIG
--VRVTEESLG---------LPALDPGSISSLKQRLSALEGELSGRTEELVQVRAALQQQ
EEEVKARGQRIQELERTVARLAEELSHENTRDSQ----------GQTDAMVNTDPLH-GL
LTRESCDKSIGVNLLGSTGSESWRAGGEENGLSGGQTSHKRGDRSPGEFVPPP-QLSLPQ
GPEVV--LTPSIPSCLSMELRI--EEAGSEQE-GS--PQVGAEGLGRVSGGSSWSSD---
-------RKSPPAGREE-ASSELPGKERPGRPPSSPT-DATIGQYVK--KIQEL-LQEQW
-SCL-EHGYPELASAIKQPASKLSSIQSQLLSSLNLLLSAYSAHAPPQ--REPPDPPT--
-----SPPMEISPSTSLKSIMKKKDYGFRAGGN--GTKKNLQFVGVNGG-----------
YETTSSE-ETSGEDSSP----EDLSDSEAEKKCDGPEHRR--GQQAHPACKPGQGLPEGS
-----STTGQESGPGE-----EPPDPKAERYKPSEEFLNACRAL-SQHLPETG---ATND
QLLRLSLNTIRQEWFRVSSRKSSSPAVVA-AYLRGVQPLSPHFLKLLVNLADG

PF00023 // ENSGT00530000063448_2_Domain_1 (1014, 1040)

NGNTALH
YSVSHSNFSVVKLLLETGVCNVDHQNK--AGYTAVMITPLASAETDEDMAVVWKLLREGN
V--NIQATQG

PF00023 // ENSGT00530000063448_2_Domain_3 (1091, 1121)

GQTALMLGVSHDRQDMVQALLSCQADVNLQ

ENSGT00530000063448_2_Linker_3_4 (1121, 1124)

DHE

PF00023 // ENSGT00530000063448_2_Domain_4 (1124, 1149)

GSSALMLACHHGNADMV
RLLLAHPACDSTLTDKAGRTALSIVLKSP---AHVEIAGLLQAHAEQGRSLGP------

-------------------------------------------MEKTDA-KDQSCQGD-E
EKDPPKRH

PF12075 // ENSGT00530000063448_2_Domain_0 (69, 107)

PYSVETPYGFHLDLDFLKYVDDIEKGNTIKRIPIHRRS

ENSGT00530000063448_2_Linker_0_1 (107, 1014)

KQAKFSTLPRNFSL
PDSGARPPTAPP-PQNWSPVVP--------RKASLGTQEQTQSLPL-GNASQA--STSAS
EVSYHRRALLAEATRQLEAA-EAEDAEVTLGSGRPQLLRASSMPATLLHSRAS-EEPGLS
LGPPAPPALPPLQGEGSVCD--GTFGPAEGLAG-FHSSSPQAS----------------T
RI----PELVQEGAEPPEG--------T--VKAPNHLPLPGPPSSFQNVLVVLEDKEDEH
KARRAEV---VFSPGSPTPSPPPLPSPIPENELLLEEIELNISEIPPP-PPVEVDVRSIG
--IRVTEESLG---------LARVDPGSISSLKQQVSALEGELSGRTEELVQVRAALQQQ
EEEIKAREQRIRELEFTVAQLEGQLHQENTKDTQ----------GQTDAMVNTDPVH-GL
LTRESCDKGIEVNLLGSMESESWGHRGEENGLLWGPDGHKQGDQSPAEHV--P-QLSLPQ
GPEQV--LTPSVHSFLSTKLRI--EEADTEQE-GG--PQG----GTREAGGFPWASD---
-------RKTPPAGREE-ANSDLPGKERPGRPPSSPT-DATIGQYVK--KIQEL-LQEQW
-SCL-EHGYPELASAIKQPASKLSSIQSQLLSSLNLLLSAYSAQAPPP--KEP--SASS-
----SSPPMEISPLTSLKSIMKKKDYGFRAGGN--GTKKNLQFVGVNGG-----------
YETTSSE-ETSGEDSSP----EDLSDSEAEKKCDGPDHRH--VKDAHLTCEAGQGIPEGT
-----CHAAQESGAGE-----EVPQSKAERYKPSEEFLNACQAL-SQHLPETG---TTTD
QLLRQSLNTISQEWFRVSSRKSSSPAVVA-SYLCEVQPHSPHFLKLLVNLADR

PF00023 // ENSGT00530000063448_2_Domain_1 (1014, 1047)

NGNTALH
YSVSHSNFSIAKLLLETGVCNVDHQNK--AGYTAVMITPLASAETKEDMAVVWKLLREGN
V--NIQATQGGQTALMLGVSHDREDMVQA

PF13857 // ENSGT00530000063448_2_Domain_4 (1110, 1165)

LLSCQADVNLQDHDGSSALMLACHHGNVDLV
RLLLAHPACDSSLTDKAGRTALSIALKSP---THMEIAGLLRAHAEQGRSLGL------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------LSHQITPLAISLN-----WT--PQFA--SVQG------
-SDALGLL-EISPTTSLKSIMKKKGYGFHAGGN--GTKKNLQFVGVNGG-----------
YETTSSE-DTSCEDSPS----EGDVESETERRAGSLEPTQEEGGGESEGASLGPSSQ---
-ERHEEDDRQEPAAE----ATPGAEHKADRCKPSEDFLADCQLL-SQHLSEIR---TTSD
KHLRQVLSTVCQEWFRVSSRKSSSPEVVA-AYLQALGAIQPQLLEVVVNLADR

PF00023 // ENSGT00530000063448_2_Domain_1 (1014, 1046)

NGNTALH
YSVSHSNFPIAKLLLDTGVCRLDLPNRA--GY----------TETGEDMAVVMRLLKEGD
V--NVRAAQ

PF00023 // ENSGT00530000063448_2_Domain_3 (1090, 1122)

GGQTALMLGVSHEREDMVRALLSCQADVNLQDEQGTTALMVACRQGNADMV
RLLLAQPGCQLTLTDK

PF00023 // ENSGT00530000063448_2_Domain_5 (1157, 1192)

DGESALSLAQQS----AHGDIAALLLCAQHG-PSTSA------

-------------------------------------------------------QGD-E
EKDSPKSH

PF12075 // ENSGT00530000063448_2_Domain_0 (69, 107)

PYSVETPYGFHLDLDFLKYVDDIEKGNTIRRVPIRRRT

ENSGT00530000063448_2_Linker_0_1 (107, 1007)

KQAKFSTLPRNFSL
PDSSVCPQTALL-QQRWSPTV--------PRKVFLGPQVQTQAPAPWGSTPQA--WAGGS
ELSNPRKALLVEADGQW------KDAALGLGSARPQLLRASSMPGTLLPSRAL-------
EGLPAPPAPPPLQDTGGSWD--GSFKPAEDPGL-------GAS-----------------
-A----VETAEELGDLVLGVPEEAERPAGEVQAPDRLSPPGPPPSFQSAPFIPEDVGVEV
QTWGPQV---GSTLGSSTPSPPPLPSPVPESELTLAGMELSISELPLP-PPPEVAVRSVG
--VRVTEEALGPDGS----------------LGQQLSALQRELASRTEELAAVRAAL---
----EAREQRVRELQGTVAQLEEKLTQDAQARA--------------HASV---------
-----------------------------------------HTGAPPGEQCPA-QLALPR
GPGTS--PASPMYSCPAMELRI--EEPAGSGQEGD--AGLAAEGTSG--------SD---
-------GEVALAAGEE-AGPEQ----PGGLPG-SPA-DAALGQYVR--KIQEL-LQEQW
-SCL-EHGYPELASALRQPASRLSSIRGQLLSSLSLLLSAYAAQGPQQEPAGHPGPSPPA
PGESPAPCAHVSPPPSLKSVMKKKDCGFGAAGN--GGKKNLQFVGVNGG-----------
YETTSSE-ETSAEDSSP----EGLSDSEAGENGGDP--ECVRHGDAHPEQ----GHPEAT
-----RSTGRGSAPAEGA-----SHPEAERCKPSEEFLHACRAL-SQHPPEAEA----AD
PLLRQSLNTVSQEWFRVSSRKSSSPAVVA-AYLLGVQPLSPHLLKL

PF13637 // ENSGT00530000063448_2_Domain_1 (1007, 1035)

LVNLADRNGNTALH
YSVSHSNFPIAKLLLDTGVCAVDRQNE--AGYTAVMITPLASAETDEDMAVVWRLLREGN
V--NIQATQGGRTALMLAVVHGRGDMVRA

PF13857 // ENSGT00530000063448_2_Domain_4 (1110, 1165)

LLRCRADVNLRDHAGRTGLMLAVRRGSAGLV
RLLLAQPACDSSLADEAGRTALSLALQPP---ARADIAGLLRAHAERAGGRGSEQPQQD

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------MKKKDYGFRAGGN--GTKKNLQFVGVNGG-----------
YETTSSE-ETSGEDSSQ----EDLSDSETEKKCEGLEHRR--DKDTHPSYEAGQGVTE--
--------GQTSGPGE-----EVSHPKAERCKPSEEFLNACQAL-SQHLPEIR---TTAD
QLLRQSLNTISQEWFRVSSRKLSSPAVVA-AYLLEVQPH

PF12796 // ENSGT00530000063448_2_Domain_1 (1000, 1057)

SPHLLKLLVNLADRSGNTALH
YSVSHSNFAIVKLLLDTGVCNVDHQNK--AGYTAVM

ENSGT00530000063448_2_Linker_1_4 (1057, 1110)

ITPLASAETKEDMAVVWKLLREGN
V--NIQATQGGQTALMLGVSHDREDMIQA

PF13857 // ENSGT00530000063448_2_Domain_4 (1110, 1164)

LLSCQADVNLQDHDGSTALMLACHQGNADLV
RLLLAHPACDSGLTDKAGHTALSIVLKSP---AHVEIAELLQAHAEQGRSLGL------

-------------------------------------------MEKTDA-KDQSSQGD-E
EKEPPKSH

PF12075 // ENSGT00530000063448_2_Domain_0 (69, 107)

PYSVETPYGFHLDLDFLKYVDDIEKGNTIKRIPIHRRA

ENSGT00530000063448_2_Linker_0_1 (107, 1009)

KQAKFSTLPRNFSL
PDSGARPSAAPP-PYNWSPVVP--------RKASCGTQEQTQSLPL-GNALQA--STSAS
EVSYHRRALLAEATRQLEAA-EPEDAKLTPGSGRPQLLRASSMPATLLHSRAS-EEPGLS
PGPTAPPPLPPLQGEGSVCD--GIFGPTEGLAG-FQSSSPQAP----------------T
QI----LELVQKGAEPPEG--------M--VKAPNHLPLPGPSSSFQNALIVLEDEEDEH
KAREAEG---VFTPGSPTPSPPPLPSPIPENELLLEEVELNISEIPPP-PPVEVDVRSIG
--IRVTEESLG---------LAKVDLGSISILKQQVSALEGELSGRTEELAQVRAALQQQ
EEEIKTREQRIRELECTVAQLEGQLHQEDAKDAQ----------GQADAMVNTDPVH-GL
LTRESCDKSIEVNLLGSMESESWGHRGEENGLLWGPGGHKQGDQSPAGHVLPP-LLSLPQ
RPEQV--LTPSVHSFLSTELRI--EEADSEQE-GG--PQG----EARGAGGSPWGSD---
-------RKTPPAGREE-ASSELPGKEHSGRPPSSPT-DATIGQYVK--KIQEL-LQEQW
-NCL-EHGYPELASAIKQPASKLSSIQSQLLSSLNLLLSAYSAQAPQP--KEP--PASS-
----SSPPMEISPSTSIKSIMKKKDYGFRAGGN--GTKKNLQFVGVNGG-----------
YETTSSE-ETSGEDSSP----EYLSDSEAEKKCDGPDHRH--VKDAHLTCEAGQGIPEGS
-----HCATQESGPGE-----EVPHSKAERYKPSEEFLNACRAL-SQRLPETG---TTTD
QLLRQSLNTISQEWFRVSSRKSSSPAVVA-AYLREVQPHSPHFLQLLV

PF13637 // ENSGT00530000063448_2_Domain_1 (1009, 1035)

NLADRNGNTALH
YSVSHSNFSIVKLLLETGVCNVDHQNK--AGYTAVMITPLASAETSEDMAVVWKLLREGN
V--NIQATQGGQTALMLGVSHDREDMVQA

PF13857 // ENSGT00530000063448_2_Domain_4 (1110, 1165)

LLSCQADVNLQDHDGSSALMLACHHGNVDLV
QLLLAHQACDSSLTDKAGRTALSIALKSP---THMEIAGLLRAHAEQGRSLGL------

-------------------------------------------MEKTDA-KDQSSQGD-E
EKEPPKSH

PF12075 // ENSGT00530000063448_2_Domain_0 (69, 107)

PYSVETPYGFHLDLDFLKYVDDIEKGNTIKRIPIHRRA

ENSGT00530000063448_2_Linker_0_1 (107, 1000)

KQAKFSTLPRNFSL
PDSGARPSAAPP-PNKCSPVVP--------KTASCGIQEQPQSLPL-GNDPQA--STSAS
EVSYHRRALLAEATRQLEAA-EPEDIELTPGSGRPQLLRASSMPATLLHSRAS-EEPGLS
PGPPAPPPLPPLQGEGSVCH--GTFGPTEGLAG-FQSSSPQAP----------------T
WI----PELVQKGAEPPGG--------M--VKAPNHLPLPGSSSSFQNALVVLEDEEDEH
KAREAEG---LFTPGSPTPSPPPLPSPIPENELLLEEIELNISEIPPP-PPVEVDVRSIG
--IRVTEESLG---------LARVEPGSISVLKQQVSALEGELSGRAEELAQVRAALQQQ
EEEIKAREQRIRELECTVAQLEGQLHQENAKDAQ----------GQADAMVNTDPVR-GL
LTRDLCDKSIEVNLLGSMESESWGHRGEDNGFLWGPGSHKQGDQSPAGHVLPP-PLSLPQ
GPEQV--LTPSVHSFLSTELRI--EEADSEQE-GG--PQG----EARGPGGSPWGSD---
-------RKTPPAGREE-SSSELPGKEHSGRPPSSPT-DATIGQYVK--KIQEL-LQEQW
-NCL-EHGYPELASAIKQPASKLSSIQSQLLSSLNLLLSAYSAQAPQP--KEP--PASS-
----SSPPIEISPSTSIKSIMKKKDYGFRAGGN--GTKKNLQFVGVNGG-----------
YETTSSE-ETSGEDSSP----EDLSDSEAEKKCDGPDHRH--VKDAHLTCEAGQGIPEGS
-----CCATQESGPGE-----EVPHSKAERYKPSEEFLNACRAL-SQRLPETG---TTTD
QLLRQSLNTISQEWFRVSSRKSSSPAMVA-AYLREVQPH

PF12796 // ENSGT00530000063448_2_Domain_1 (1000, 1057)

SPHFLQLLVNLADRNGNTALH
YSVSHSNFSIVKLLLETGVCNVDHQNK--AGYTAVM

ENSGT00530000063448_2_Linker_1_4 (1057, 1110)

ITPLASAETSEDMAVVWKLLREGN
V--NIQATQGGQTALMLGVSHDREDMVQA

PF13857 // ENSGT00530000063448_2_Domain_4 (1110, 1165)

LLSCQADVNLQDHEGSSALMLACHHGNVDLV
RLLLAHPACDSSLTDKAGRTALSIALKSP---THMEIAGLLRAHAEQGRSLGL------

-------------------------------------------MLLFSG-DDWTSKA--E
DKDP-PPS

PF12075 // ENSGT00530000063448_2_Domain_0 (69, 107)

PYSVETPYGFHLDLDFLKYVDDIEKGNTIKRIQIHRKT

ENSGT00530000063448_2_Linker_0_1 (107, 1014)

KYPKFSTLPRNFSL
PENGSRARNKN----------FIAQ-----RKASLGADESTHLITP-TDSTP--FSGISN
EPNYRRKALLIETTRQDPMKL---AEENGSCRGRPQLLRASSMPATLPPNQNS-EEEETP
LTFLQ-------SCDAKSLE--NSFSPANESPESESSKGV--S-LTAPDGLMTVKQKINK
LV----PETERENTQLGLNQK-----HIVKERMRPSASWEGQPFISQELLVVAESGEEEC
DTVEMNIRPPPVQSGSSCSMT----LEYKFENQIPEDIELSICETE---VLEEGKVVSSG
--IRQMEESSNLE------CLPSEEPSNIIALKQHIAILEEQLNNKTEELAQIRVVLKEQ
DKEIKAKEKSIEMLASSKAQLEEKLCGESTKE-------------YHDAAVNTELVH-EK
IAKEAYDKGVNVRLTVPMESVECDVCEADNKNLQVKEMHRKLFHVPDEMSNIPVCIQEKR
QKEMKQDNDSSTLELSYNELKI--DEHTANDKSEKK-A---YNNVS---RGESSLSVGTT
DSTT---GKNEHNFQGD-IRQDSTE-EGNNSEPKKVTTDPSVSQYVK--KIQDL-LQEQW
-MCL-EHGYPELASAIKQPASKLSSIQNQLVNSLNLLLSAYSTQTPTD--KNM-------
PDYATSFPLEISPSTSLKSIMKKKETGYHAGGN--GTKKNLQFVGVNGG-----------
YETTSSE-DSSCEETSS----EGNSDSETERKCDNEEHRWREDGD--EGDENASGTSQCV
----KHEDTDGKELEETL-RGSMQPHKAERFKPSADFLKGCQIL-SKHIPEIR---NTKD
KLLRHVLSTISQEWFRISSRKSSSPEIVA-AYLREVEVIHPQLQNIVVNLADG

PF00023 // ENSGT00530000063448_2_Domain_1 (1014, 1040)

NGNTALH
YSVSHSNFQIVKLLLETGVCDVDHQNK--AGYTAVMITPLASAETDEEMEVVTKLLREGN
V--NIRASQGGQIALILGVSHDREDMVKALLSSGADINLQDDT

PF00023 // ENSGT00530000063448_2_Domain_4 (1124, 1147)

GLSPLMVASQYGNMDIV
KLLLDHPGCDTTLNDKAGNSALSMALKS----AHVEIAEILQSHKQHSWPLNT------

-------------------------------------------MEKTDA-KDQSSQGD-E
EKDPPKSH

PF12075 // ENSGT00530000063448_2_Domain_0 (69, 107)

PYSVETPYGFHLDLDFLKYVDDIEKGNTIKRIPIHRRA

ENSGT00530000063448_2_Linker_0_1 (107, 1014)

KQAKFSTLPRNFSL
PDSGARPHAVLS-HPNWSPMVS--------RKV-LGTEARAQPLPL-GDHPQAPQAASGS
ELSYHRKALLMETARQLEAAAAPGEAELTSGSGRPQLLRASSMPATLLQTRAS-EDPSLN
SGPPTPPVLPQLQGEGVVCD--DAFGPAEGFAG-FSNSTPRAATHLEVRESGDL----VP
GI----AELIQEGPEPPES--------E--EEAPNHLSFPSPPFSSQNALVVLEEAEDQQ
ESRGAQV--VVTSPSSPTPSPPPLPSPIPENELPLEEIELNISEIPPP-PPVEVDVRSIG
--IRVTEESLG---------LASLDPGSISSLKQQISDLEGELSGRTEELAQVRAALQRQ
EEEIKARGQRIQELECTVAQLVEKLSGGNTKDAQ----------GQTDAMVGTDPLQ-GL
LTRQSCDKSIGVSLLGSVGSESWGARGEGNGPLWGRESHTRGDGSPAGLVSPS-QPSLPQ
GSETV--LMPSSHSCLSTELRI--EEGGSEQA-GG--SSVGIKGLDRGVGGSPGSAE---
-------RKAPPAGREE-AGPELSGKERPGRPPGSPT-DATIGQYVK--KIQEL-LQEQW
-SCL-EHGYPELARAIKQPASKLSSIQSQLQSSLNLLLSAYSAQAPPQ--KEP--PGPS-
----SSPPMEISPSTSLKSIMKKKDYGFRAGGN--GTKKNLQFVGVNGG-----------
YETTSSE-ETSGEDSSP----EDLSDSEAEKKCDGPEPRQ--GKDAHLSCRVSQGTHEGT
-----HDTDQETGPGE-----ELPHPKTERYKPSEEFLNACRAL-SQHLPETG---TTTD
QLLKQSLNTISQEWFRISSRKSSSPAVVA-AYLHGVQPHSPHLLKLLVNLADG

PF00023 // ENSGT00530000063448_2_Domain_1 (1014, 1040)

NGNTALH
YSVSHSNFSIVKLLLETGVCNVDHQNK--AGYTAVMITPLASAETDEDMAVVWKLLREGN
V--NIQATQG

PF00023 // ENSGT00530000063448_2_Domain_3 (1091, 1121)

GQTALMLGVSHDRGDMVQALLSCQADVNLQ

ENSGT00530000063448_2_Linker_3_4 (1121, 1123)

DH

PF00023 // ENSGT00530000063448_2_Domain_4 (1123, 1152)

DGSSALMLACCHGNTDMV
RLLLAHPACDTSLTDKAGRTALSIALKSP---THVEIAGLLRAHSKQGRPLGP------

-------------------------------------------MEKMDA-KDQSSQGD-E
EKEPPKSY

PF12075 // ENSGT00530000063448_2_Domain_0 (69, 107)

PYSVETPYGFHLDLDFLKYVDDIEKGHTIKRIPIHRRA

ENSGT00530000063448_2_Linker_0_1 (107, 987)

KQAKFSTLPRNFSL
PNSGDRTRAVPP-QQNWSPVVP--------RKISLGTQEPSQSLPL-DDLPQA--SVQGS
ELNYHRKALLAKDSRQVEAG-SLED----GGSGRPQLLRASSMPATLLQNQVP-EEPSLT
SGPSTLLALPLLQDEVSVCD--GAFDPAGGQMG-FQA-----SAQSADRELGEL----EP
AI----PEQVWEGAEPEEG--------D--IKALSHLSQPGPSSAVQNVPVDLEEVEIQH
RRREAEL---VLTPGSSTPSPPPLPSPIPENELSLEEIELSISEIPPP-PPIEVDVRSIG
--IRVTEESLG---------QLETDTSSISSLKNQVLALEDKLSGRTEELARVRAALEQQ
EEETKAREQRIQELECTVARLEEKLSQERASDAL----------DRTDATVNTDPLH-EL
IPRESHDKNIGVNLLNTADPECWPPRAEKNGFPRVQNNHKRSYPSPEEPVLPP-QLSLPR
GPEQV--LASSLCSCLSMELRI--EEEVSEQE-GG--PQGGAGGLSRAAGDSSWST----
-------RESAPVISEK-ASSELPGAERPGRPASSPQ-DATIGQYVK--KIQEL-LHEQW
-NCL-EHGYPELASAIKQPASKLSSIQNQLLSSLNLLLSAYSAQAPE--PKETPAPPPSA
----PPPPPEISPSTSLKSIMKKKDYGFRAGGN--GTKKNLQFVGVNGG-----------
YETTSSE-ETSGEDSSP----EDLSDSETEKKQDRSEPREGRDRDLHPGWEAGQGVPAGT
-----RNSGHTSDHGE-----EVSHLRTERYKPSEEFLNACQTL-SQHLPETG---DTTK
QLLRQSLNTISQEWFRVSSRKLSSPE

PF13637 // ENSGT00530000063448_2_Domain_1 (987, 1035)

AVA-AYLLKVQPHSPHLLKLLVNLADRSGNTALH
YSVSHSNFAIVKLLLDTGVCNVDHQNK--AGYTAVMITPLASAETKEDMAVVWRLLREGN
V--NIQATQGGQTALMLGVSHDREDMVQA

PF13857 // ENSGT00530000063448_2_Domain_4 (1110, 1164)

LLSCQADVNLQDNDGSSALMLACHQGNADLV
RLLLAHPACNRSLTDKAGRTALSLVLNSP---AHVEIAELLQAHSEPGRSLGPKELQKN

-------------------------------------------MEKTDA-AGQPPLPN-G
DGEQPRSLPYSLETPYGFHLDLDFLKYVDDIEKGNTIRRVHIHRKAKQPKFSTLPRNFSL
PENGSHGYAASA-GPGWPAATYRAQ-----RKASLGAEEISRAPLP-----------GE-
EPSYRRKALLAETRRHAELL-HCED----ELRGRPQLLRASSLPAALPPGRAP-AGDGCV
PCPLR-------PSDNGSCPES-TFRPMPRSPDGIASLPSPML--SPGAELAL-----QP
GK----GSLVR---------------DVPKER--AQPLWQGQHSAV-QLQVVVESRGEEG
DASDATN-------GSTLVSVSPGTLPLADESTSHGKAGGSVSEIAVN-VLKESKDRCAR
--AQEKEERGG----------DAGESGGIAALKQHIAALEEQLDRKKEELEQIRAVLKQQ
DHKIKEKEKSIQLLASSKAQLEEQLCQENTREDAVSSMRRGSMLQYNDAAVNTELSY-VN
GSKQVHDKGINVNIPLSTKSIGCGIRRADSGNLLAAELSAQGWADVGTRGGGD--GHFAK
LSETEAGLEPGLHAPGFTELKI--NEQLSDDNQNQRNSCDTQSLAAHAVAAESYRTKRT-
---GS-----------N-KTEDGMGEEGLPDPKDFPA-VDPIGQYVK--KIQEL-LQEQW
-MCL-EHGYPELASAIKQPASKLSSIQNQLVNSLNSLLSAYSSQRPAD--KENS------
-NTHYQQL-ETSPTTSLKSIMKKKGYGSHAGGN--GTKKNLQFVGVNGG-----------
YESTSSE-DTSCEDSPS----DGDAESDTERGAGGLEPTKEQGGGGSEGASFGTSLQ---
-ETQKDDDLQEPGAE----AAPCTQRKADSGTN---YIHEVKRL-NKHLKYSDLNCTLSL
FLQRHVLSTVCQEWFRVSSRKSSSPEVVT-AYLQALGTIQPQLLEAVVNMADR

PF00023 // ENSGT00530000063448_2_Domain_1 (1014, 1046)

NGNTALH
YSVSHSNFTIAKLLLDTGVCRLDLPNQ--AGYTAVMLTPLAAAETDEDMAVVMRLLKEGD
V--NVRAAQ

PF00023 // ENSGT00530000063448_2_Domain_3 (1090, 1122)

GGQTALMLGVSHEREAMVRALLACQADVNLQD

ENSGT00530000063448_2_Linker_3_4 (1122, 1123)

E

PF00023 // ENSGT00530000063448_2_Domain_4 (1123, 1155)

QGSTALMVACRQGSTNMV
RLLLAQPGCQLALTDKDGDTALAIAQRS----AHEDIAALLHSAQHG-PSD--------

-------------------------------------------MEKIDG-KDQSSQGD-E
EKEPPKSY

PF12075 // ENSGT00530000063448_2_Domain_0 (69, 107)

PYSVETPYGFHLDLDFLKYVDDIEKGHTIKRIPIHRRA

ENSGT00530000063448_2_Linker_0_1 (107, 987)

KQAKFSTLPRNFSL
PNSGDRTYAVPP-QQNWSPVVP--------RKISLGTQEPSQPLPL-GDLPQA--SVQGS
ELNYHRKALLAKDARQAEAG-SLED----VGSGRPQLLRASSMPATLLQNQVP-EEPSLT
SGPSTLLALPLLQDEGSVCD--GAFDPAEGLMG-FQA-----SAQSVDRELGEL----EP
AI----PEQVWEGAEPEEG--------D--LKASSHLSQPGPSSAVQSVPMDLEEVEIEH
HMREAEL---VLTPGSATPSPPPLPSPILENDLSLDEIELSISEIPPP-PPIEVDVRSIG
--IRVTEESLG---------LLETDTSSISSLKNQVLALEDKLSGRTEELARVRAALEQQ
EEETKAREQRIQELECTVAHLEEKLSQERASEAP----------DRTDATVNTDPLQ-EL
TPRESHDKNIGVNLLNTPDPECRAPRAEKNGFPWVQNNHKQSYPSPEEPVLPP-QLSLPR
GPEQI--LASSLCSCLSMELRI--EEEGSEQE-GG--QEEGAGGLSRAAGESSWST----
-------RESAPVIREE-ATSELPGAERPGRPASSPQ-DATIGQYVK--KIQEL-LHEQW
-NCL-EHGYPELASAIKQPASKLSSIQNQLLSSLNLLLSAYSAQAPEPEPKETPAPPPST
PPPPPPPPPEISPSTSLKSIMKKKDYGFRAGGN--GTKKNLQFVGVNGG-----------
YETTSSE-ETSGEDSSP----EDLSDSETEKKQDCSESRE--DRDLHPSCEAGQGVPEGT
-----RNSGHTSDRGE-----EVSHLRAERYKPSEEFLNACQTL-SQHLPETG---DTTK
QLLRQSLNTISQEWFRVSSRKLSSPE

PF13637 // ENSGT00530000063448_2_Domain_1 (987, 1035)

AVA-AYLLEVQPHSPYLLKLLVNLADRSGNTALH
YSVSHSNFAIVKLLLDTGVCNVDHQNK--AGYTAVMITPLASAETKEDMAVVWKLLREGN
V--NIQATQGGQTALMLGVSHDREDMVQA

PF13857 // ENSGT00530000063448_2_Domain_4 (1110, 1164)

LLSCQADVNLQDNDGSSALMLACHQGNADLV
RLLLAHPACNSSLTDKAGRTALSLVLNSP---AHVEIAELLRAHSEPGRSLGPKELQKN

-------------------------------------------MEKTDA-KDQSSQGD-E
EKDPPKSH

PF12075 // ENSGT00530000063448_2_Domain_0 (69, 107)

PYSVETPYGFHLDLDFLKYVDDIEKGNTIKRIPIHRRA

ENSGT00530000063448_2_Linker_0_1 (107, 1014)

KQAKFSTLPRNFSL
PDSGARPPAAPP-LQNWSAVVP--------RKASLGTQEQNQSLPL-GNAPQA--STSGS
EVSYHRRALLAEATRQLEAA-EPEDAELTLGSGRPQLLRASSMPATLLHSRAS-EEPGLS
LGPLAPPALPPFQGEGSVCD--GTFGPAEGLAG-FHSSSPQAS----------------T
RI----PELVQEGAEPQEG--------T--VKAPNHLPLPGPPFSFQNALVVLEDKEDEH
KAREAEV---VFTPGFPTPSPPPLPSPIPENELLLEEIELNISEIPPP-PPVEVDMRSIG
--IRVTEESLG---------LARVDPSSISSLKQQVSALEGELSGRTEELAQVRAALQQQ
EEEIKAREQRIRELEFTVAQLEGQFQQENAKDTQ----------GQTDTLVNTDPVH-GL
LTRESCDKGIEVNLLGSMESESWGHRGEENGLLWGPDGHKQGNQSPAEHVLLP-QLSLPQ
GPEQV--LTPSVHSFLSTELRI--EEAGAEQE-GG--PQG----GTKGAGGFLWGSD---
-------RKIPPAGREE-ASSDLPGKEHPGRPPSSPV-DATIGQYVK--KIQEL-LQEQW
-NCL-EHGYPELASAIKQPASKLSSIQSQLLSSLNLLLSAYSAQAPQP--KEP--PASS-
----SSPPMEFSPSTSLKSIMKKKDYGFRAGGN--GTKKNLQFVGVNGG-----------
YETTSSE-ETSGEDSSP----EDLSDSEAEKKCDGPDHKH--VKDAHLTCEAGQGIPEGT
-----CHAAQESGPGE-----EVPHSKAERYKPSEEFLNACRAL-SQHLPETG---TTTD
QLLRQSLNTISQEWFRVSSRKSSSPAVVA-SYLHEVQPHSPHFLKLLVNLADR

PF00023 // ENSGT00530000063448_2_Domain_1 (1014, 1040)

NGNTALH
YSVSHSNFSIAKLLLETGVCNVDHQNK--AGYTAVMITPLASAETNEDMAVVWKLLREGN
V--NIQATQG

PF00023 // ENSGT00530000063448_2_Domain_3 (1091, 1121)

GQTALMLGVSHDREDMVQALLSCQADVNLQ

ENSGT00530000063448_2_Linker_3_4 (1121, 1123)

DH

PF00023 // ENSGT00530000063448_2_Domain_4 (1123, 1150)

DGSSALMLACHHGNVDLV
RLLLANPACDSSLTDKAGRTALSIALKSP---THMEIAGLLRAHAEQGRSLGL------

-------------------------------------------MEKTDA-KDQSCQGD-E
EKDPPKRH

PF12075 // ENSGT00530000063448_2_Domain_0 (69, 107)

PYSVETPYGFHLDLDFLKYVDDIEKGNTIKRIPIHRRA

ENSGT00530000063448_2_Linker_0_1 (107, 1014)

KQAKFSTLPRNFSL
PDSGARPPAALP-PQNWSPVVP--------RNASLGTQEQTQSLPL-GNASQA--STSAS
EVSYHRRALLAEATRQLEAA-EPEDAEVTLGSGRPQLLRASSMPATLLHSRAS-EEPGLS
LGPPAPPALPPLQGEGSVCD--GTFGPAEGLAG-FHSSSPQAS----------------T
RI----PELIQEGAEPPEG--------M--VKAPNHLPLPGPPSSFQNVLVVLEDKEDEH
KARKAEV---VFTSGSPTPSPPPLPSPIPENELLLEEIELNISEIPPP-PPVEVDVRSIG
--IRVTEESLG---------LARVDPGSISSLKQQVSALEGELSGRTEELVQVRTALQQQ
EEEIKAREQRIRELEFTVAQLEGQLHQENTKDTQ----------GQTDAMVNTDPVH-GL
LTRESCDKGIEVNLLGSMESESWGHQGEENGLLWRPDGHKQGDQSPAEHV--P-QLSLPQ
GPEQV--LTPSVHSFLSTELRI--EEAGTEQE-GG--PQG----GTRGAGGFLWGSD---
-------RKTPPAGREE-ANSDLPGKERPGRPPSSPT-DATIGQYVK--KIQEL-LQEQW
-NCL-EHGYPELASAIKQPASKLSSIQSQLLSSLNLLLSAYSAQAPPP--KEP--PASS-
----SSPPMEISPSTSLKSIMKKKDYGFRAGGN--GTKKNLQFVGVNGG-----------
YETTSSE-ETSGEDSSP----EDLSDSEAEKKCDGPDHRH--VKDAHLTCEAGQGIPEGA
-----CHAAQESGAGE-----EVPHSKAERYKPSEEFLNACQAL-SQHLPETG---TTTD
QLLRQSLNTISQEWFRVSSRKSSSPAVVA-SYLCEVQPHSPHFLKLLVNLADR

PF00023 // ENSGT00530000063448_2_Domain_1 (1014, 1047)

NGNTALH
YSVSHSNFSIAKLLLETGVCNVDHQNK--AGYTAVMITPLASAETSEDMAVVWKLLREGN
V--NIQATQGGQTALMLGVSHDREDMVQALLSCQ

PF12796 // ENSGT00530000063448_2_Domain_4 (1115, 1183)

ADVNLQDHDGSSALMLACHHGNVDLV
RLLLAHPACNSSLTDKAGRTALSIALKSP---THMEIAGLLRAHAEQGRSLGL------

--------------------------------------------------KDQSSQGD-E
EKGPPKSHPYSVETPYGFHLDLDFLKYVDDIEKGNTIKRIPIHRRAKQAKFSTLPRNFSL
PDSGARFHAALS-HQNWSPVV--------PRKVSLGTQGQSQSLP---LAPQA--LAGGS
EVSYHRKALLAEAARQVEAA-AVEDVELASGSGRPQLLRASSMPATLLPNRAS-EEASLS
SGAPGPAAFPPLQGESGVWD--GSFHLAEGFAG-FQSCSPQAYTR---------------
-I----PELARDGAET-----S-----EGEVKALDHLNLPSPPSSFQNALVVLEDAEDEP
EARQAEV---TFSPGTPTPSPPPLPSPIPENELPLEEIELNISELPPP-PPIELDVRSIG
--IRVTEESLGLAGAGGDAG-------SLSSLEQQVSALEGELSGRTEELAQVRAALQQQ
EEEVKAREQRIQELECVVAQLKEKLSQDNAAQAA---------QGLIDASVTG--TH-GL
LTRESCDS-IGVNLLGITESEGWEX-XXXXXXXX-----XXXXXXXXXXXXXX-XXXXXX
XXXXX--XXXXXXXXXXXXXXXXXXXXXXXX-XXX--XXX-XXXXXX-------XXX---
-------XXXXXXXXXXXXXXXXX----XXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXX---XXXXISPSTSLKSIMKKKDYGFRAGGN--GTKKNLQFVGVNGG-----------
YETTSSE-ETSGEDSSP----EDFSDSEAEGKCDGP--EHRRSRDAHPSSEAGQGIFDGT
-----QHTGQESGPGEEA-S----LSKAEXXXXXXXXXXXXXXXXXXXXXXX-X-XX--X
XXXRQSLNAISQEWFRVSSRKSSSPDVVA-AYLRGVQPLSPQFLKLLVNLADR

PF00023 // ENSGT00530000063448_2_Domain_1 (1014, 1046)

NGNTALH
YSVSHSNFSIAKLLLDTXXXXXXXXXX--XXXXAVMITPLASAETDEDMA-VWNLLREGN
V--NIQATQ

PF00023 // ENSGT00530000063448_2_Domain_3 (1090, 1122)

GGQTALMLGVSHDREDMVQALLSCQADVNLQD

ENSGT00530000063448_2_Linker_3_4 (1122, 1123)

H

PF00023 // ENSGT00530000063448_2_Domain_4 (1123, 1155)

EGSSALMLACHHGNVDLV
RLLLAHPGCDSSLTDKAGRTALSIALNSP---THMEIAGLLQAHAEQGRSLGL------

-------------------------------------------MEKLR--HKGSSQGD-E
EKDPPKSH

PF12075 // ENSGT00530000063448_2_Domain_0 (69, 107)

PYSVETPYGFHLDLDFLKYVDDIEKGNTIKRIPIHRRA

ENSGT00530000063448_2_Linker_0_1 (107, 1008)

KQAKFSTLPRNFSL
PNSGARPQAALL-HQNWSPGVP--------RKVSLVAQEQTQSLLP-GTAPQA--AASGS
ELSYHRRAVLAEATRQLEAA-APEDAELGSGSGRPQLLRASSMPATLQQSRAS-EEPSLS
SGAPAPPTFPPLRGEGSVCD--GAFGPAEGFAG-FHSSSPRAS-----------------
PQ----PKLVREGAEPPEG--------G--VTAPNHLCLPAPPSSFPNALVGLEDAEDER
EARAAEV---VVSPGSPTPSPPPLPSPIPESELPLEEIELNISEIPPP-PPVEVDVRSVG
--VRVTEESLG---------LAGAGAGGVSSLKQQVSALEGELSGRTEELAQVRAALQQQ
EEEVKAREQRIQELERAVAQLEEKLSQETAKDAQ----------GQADATVNTDPLH-GL
LTRESCDKSIEVNLLGITESESWGAQGGENGLLWGQDSHKQGDQSPAEHVLPP-QLSLLQ
GPEKV--LSSSLHSCLSTELRI--EEAGTEQEEEG--PQGGA-----EAGGFAWSSD---
-------RKTPPAGRQE-PSSELPGKEHPERPPSSPT-DATLGQYVK--KIQEL-LQEQW
-SCL-EHGYPELASAIRQPASKLSSIQSQLLSSLNLLLSAYSAQAPQH--KEP--PAPS-
----SSPPKEISPSTSLKSIMKKKDYGFRAGGN--GTKKNLQFVGVNGGTGQVTFVSLPS
YETTSSE-ETSGEDSSP----EDLSDSEAEKKCDGPEHRW--TKDAHPSYEAGQGVPEGT
-----HHAGQESGPGE-----EVPHSKAERYKPSEEFLNACRAL-NQHLPETG---TTTD
QLLRQSLNTISQEWFRISSRKSSSPAVVA-AYLHGVQPHSPHFLKLL

PF13637 // ENSGT00530000063448_2_Domain_1 (1008, 1035)

VNLADRNGNTALH
YSVSHSNFSIAKLLLETGVCNVDRQNK--AGYTAVMITPLASPETDEDMAVVWKLLREGN
V--NIQATQGGQTALMLGVSHDREDMVEA

PF13857 // ENSGT00530000063448_2_Domain_4 (1110, 1164)

LLSCQADVNLQDHDGSSALMLACHHGNTDMV
RLLLAHPACDSSLTDKAGRTALSIVLKSP---THMEIAGLLWAHAEQGRSLGP------

-------------------------------------------MEKTDA-KDQSCQGD-E
EKDPPKRH

PF12075 // ENSGT00530000063448_2_Domain_0 (69, 107)

PYSVETPYGFHLDLDFLKYVDDIEKGNTIKRIPIHRRT

ENSGT00530000063448_2_Linker_0_1 (107, 1014)

KQAKFSTLPRNFSL
PDSGAHPPTAPP-PQNWSPVVP--------RKASLGTQEQTQSLPL-GNASQA--STSAS
EVSYHRRALLAEATRQLEAA-DPEDAEVTLGSGRPQLLRASSMPATLLHSRAS-EEPGLS
LGPPAPPALPPLQGESSVCD--GTFGPAEGLAG-FHSSSPQAS----------------T
QI----LELVQEGAEPPEG--------T--VKAPNHLPLPGPPSSFQNVLVGLEDKEDEH
KARKAEV---VFTSGSPTPSPPPLPSPIPENELLLEEIELNISEIPPP-PPVEVDVRSIG
--IRVTEESLG---------LARVDPGSISSLKQQVSALEGELSGRTEELVQVRAALQQQ
EEEIRAREQRIRELEFTVAQLEGELHQENTKDTQ----------GQTDAMVNTDPVH-GL
LTRESCDKGIEVNLLGSMESESWGHRGEENGLLWGPDGHKQGDQSPAEHV--P-QLSLPQ
GPTQV--FTPSVHSFLSTELRI--EEAGTEQE-GG--PQG----GTRGAGGFLWGSD---
-------RKTPPAGREE-ANSDLPGKERPGRPPSSPT-DATIGQYVK--KIQEL-LQEQW
-NCL-EHGYPELANAIKQPASKLSSIQSQLLSSLNLLLSAYSAQAPPP--QEP--PASS-
----SSPPMEISPSTSLKSIMKKKDYGFRAGGN--GTKKNLQFVGVNGG-----------
YETTSSE-ETSGEDSSP----EDLSDSEAEKKCDGPDHRH--VKDAHLTCEAGQGIPEGA
-----CHAAQESGAGE-----EVPHSKAERYKPSEEFLNACQAL-SQHLPETG---TTTD
QHLRQSLNIISQEWFRVSSRKSSSPAVVA-SYLCEVQPHSPHFLKLLVNLADR

PF00023 // ENSGT00530000063448_2_Domain_1 (1014, 1047)

NGNTALH
YSVSHSNFSIAKLLLETGICNVDHQNK--AGYTAVMITPLASAETNEDMAVVWKLLREGN
V--NIQATQGGQSA

PF12796 // ENSGT00530000063448_2_Domain_4 (1095, 1183)

LMLGVSHDREDMVRALLSCQADVNLQDHDGSSALMLACHHGNVDLV
RLLLAHPACDSSLTDKAGRTALSIALKSP---THMEIAGLLRAHAEQGRSLGL------

-------------------------------------------------------QRD-E
ERGSSKSC

PF12075 // ENSGT00530000063448_2_Domain_0 (69, 107)

PYSVETPYGFHLDLDFLKYVDDIEKGNTIKRVPIHRRA

ENSGT00530000063448_2_Linker_0_1 (107, 1014)

KQAKFSTLPRNFSL
PSSGVRPPAALL-QQSWSPAV--------PRKVSLGLQEQTRPQVPQSSPPQA--WAGGS
KLSHPRKALLAEATGQG------EDAVPSCASARPQLLRASSMPATLLPSRAL-------
EGPPTPPAPPPLQDTGGTWD--EAFRP---------------------------------
---------------GVLGIPKEYELPTGESQALDYPCPPGPPPPFQSVPVVPEHLGAEG
QKEGTQL---ASTPGSSTPSPPPLPSPVPESELALGDIELNISELPPPPSPLEMAVQSVG
--MRVTEEALGLDGS----------------LGQQLWALQDELASRVEELASIRVTL---
----EAKEQRILELESTVAQLEEKLSQDAQ--DP---------QGHIDAAVGTDPLC-DL
HRVETHDKGVGVTFLSPADSGNQGV-LGESGNLL-----WLSLPQQ--------------
-SCPV--PASPVHSCLSTELRI--EEPASLGQEAV--EGLAAEGTLG--------SD---
-------GEAASVAREE-AGSQHP----AGLPG-SSP-DAALGQYVR--KIQEL-LQEQW
-SCL-EHGYPELASALRQPASRLSSIRGQLLSSLSLLLSACAAQGPQQEPAGHPAPSPPA
PTP---SAPEISPPTSLKSIMKKRDCGFRAGGN--GARKSLQFVGVNGG-----------
YETTSSE-ETSGEDSSP----EDLSDSEAEKKCSDP--DLLPAQ----------------
-------VMAARF-----------PVVLSRCKPSEEFLSACRAL-GQHPLET-V-AT--D
PLLVQ---PFLIEWFRVSSRKSSSPAVVA-AYLLEVQPLSPHLLKLLVNLADG

PF00023 // ENSGT00530000063448_2_Domain_1 (1014, 1046)

NGNTALH
YSVSHSNFPIAKLLLDTGVCAVNRQ

ENSGT00530000063448_2_Linker_1_3 (1046, 1070)

NK--AGYTAVMITPLASAETTEDM

PF12796 // ENSGT00530000063448_2_Domain_3 (1070, 1149)

AVVWQLLREGN
V--NVQATQGGQTALMLGVSHDRGDMVHALLHCQADVNLQDHEGATALMLACRHGNADLV
KLLLAQPS

PF12796 // ENSGT00530000063448_2_Domain_4 (1070, 1149)

AVVWQLLREGNV--NVQATQGGQTALMLGVSHDRGDMVHALLHCQADVNLQDHEGATALMLACRHGNADLVKLLLAQPSCDSSLADK-------------------------------------------

-------------------------------------------MEKIDG-KDQSSQGD-E
EKEPPKSY

PF12075 // ENSGT00530000063448_2_Domain_0 (69, 107)

PYSVETPYGFHLDLDFLKYVDDIEKGHTIKRIPIHRRA

ENSGT00530000063448_2_Linker_0_1 (107, 984)

KQAKFSTLPRNFSL
PNSGDRTHAVPP-QQNWSPVVP--------RKISLGIQEPSQPLPL-GDLPQA--SVQGS
ELNYHRKALLAKDARQVEAG-SLED----VGSGRPQLLRASSMPATLLQNQVP-EEPSLT
SGPSTLLALPLLQDEGSVYD--GAFDPAEGLMG-FQA-----SAQSADRELGEL----EP
AI----PEQVWEGAEPEEG--------D--LKASSHLSQPGPSSAVQSIPMDLEEVEIQH
DMREAEL---VLTPGSATPSPPPLPSPILENDLSLDEIELSISEIPPP-PPIEVDVRSIG
--TRVTEESLG---------LLETDTSSISSLKNQVLALEDKLSGRTEELARVRAALEQQ
EEETKAREQRIQELECTVAHLEEKLSQERASEAP----------DRTDAMVNTDPLH-EL
IPRESHDKNIGVNLLNTPDPECRAPRAEKNGFPWVQNNHKQSSPSPEEPVLPP-QLSLPR
GPEQV--LASSLCSCLSMELRI--EEEGSEQE-GG--PQEGAGGLSRAAGDSSWST----
-------RESAPVIREE-ASSELPRAERPGRPASSPQ-DATIGQYVK--KIQEL-LHEQW
-NCL-EHGYPELASAIKQPASKLSSIQNQLLSSLNLLLSAYSAQAPE--PKETPAPPPST
PPP--PPPPEISPSTSLKSIMKKKDYGFRAGGN--GTKKNLQFVGVNGG-----------
YETTSSE-ETSGEDSSP----EDLSDRETEKKQDCSESRE--DRDLHPSCEAGQGVPEGT
-----RNSGHASDHGE-----EVSHLRAERYKPSEEFLNACQTL-SQHLPETG---DTTK
HLLRQSLNTISQEWFRVSSRKLS

PF13637 // ENSGT00530000063448_2_Domain_1 (984, 1035)

SPEAVA-AYLLEVQPHSPHLLKLLVNLADRSGNTALH
YSVSHSNFAIVKLLLDTGVCNVDHQNK--AGYTAVMITPLASAETKEDMAVVWKLLREGN
V--NIQATQGGQTALMLGVSHDREDMVQA

PF13857 // ENSGT00530000063448_2_Domain_4 (1110, 1164)

LLSCQADVNLQDNDGSSALMLACHQGNADLV
RLLLAHPACNSSLTDKAGRTALSLVLNSP---AHMEIAELLRAHSEPGRSLGPKQLQKN

--------------------------------------------------KDQSSQGD-E
EKDPPKSHPYSVETPYGFHLDLDFLKYVDDIEKGNTIKRIPIHRRAKQAKFSTLPRNFSL
PDGGARPHAAPS-HPHWSPMVP--------RKVSLGTGERAQPLAL-GDHPQA--AAGGT
GVSYHRKALLAETARQLEXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXX
XX----XXXXXXXXXXXXXX--XXXXXXXXXXX-XXXXXXXXX-X-----XX-X-----X
XX----XXXXXXXXXXXXX--------X--XXXXXXXXXXX-XX-XXXXXXXXXXXXXXX
XXXXXXX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXISEIPPP-PPVEVDGRSVG
--TRVTEESLG---------LARMDPGGISSLKQRLSDLEGELSGRTEELAQVRAALQRQ
EEEIKGRGQRIRELECTVAQLAEKLSHKSTKDAQ----------GQTEAMVNTGPLH-GL
LTTESCDKSIGVNLLDSMGSGSWGAGGEGNSLLWGQDSHKQGDRSPAELVPPP-QLSLPQ
GPEMV--LTPSLHSCLSTELRI--EEAGSEQE-GG--PQLRAEGPIRGAGGSPGSSE---
-------REAPPAGREE-A-SELPGKERPGRPPSSPT-DATIGQYVK--KIQEL-LQEQW
-SCL-EHGYPELARAIKQPASKLSSIQSQLQSSLNLLLSAYSAQAPPQ--KEP--TGAS-
----SSPPMEISPSTSLKSIMKKKDYGFRAGGN--GTKKNLQFVGVNGG-----------
YETTSSE-ETSGEDSSP----EDLSDSEVEKKCDGPEHRP--GKDAHLSCKAGQGITEGT
-----SNTDQGSGPGE-----ELPHPKAEXXXXXXXXXXXXXXX-XXXXXXXX---XXXX
XXXRQSLNTISQEWFRVSSRKSSSPDVVA-AYLRGVQPHSPHLLKLLVNLADG

PF00023 // ENSGT00530000063448_2_Domain_1 (1014, 1047)

NGNTALH
YSVSHSNFSIVRLLLETGVCNVDHQNR--AGYTAVMITPLASAETDEDMAVVWKLLREGN
V--NIQATQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXAGRTALSIALKSP---AHVEIAGLLRAHAKQGRSLGP------

-------------------------------------------MEKTDA-KDRSSQGD-E
EKDSPKSH

PF12075 // ENSGT00530000063448_2_Domain_0 (69, 107)

PYSVETPYGFHLDLDFLKYVDDIEKGNTIKRIPIHRKA

ENSGT00530000063448_2_Linker_0_1 (107, 1014)

KQAKFSTLPRNFSL
PDSGARPRAALP-HPKWSSVVP--------REESPGTEERSPSLPL-GGSSHA--AGSGS
EVSYHRKALLAETARQLEAA-PPEEAGLPSGSGRPQLLRASSMPATLLQNKAS-EELSLS
SAPPPPPALLPFQGEGGVCD--GTFGPAEEFAG-FHSSSPRASTQLKVREFGEL----VP
GI----PELAQEGPESAEG--------E--EEAPNHLSLPRSPS-SQNAFVVLEEAADEH
ATREAEV---VVTPDSPTPSPPPMPSPIPENEFPLEEIELNISEIPPP-PPIEVDVRSIG
--IRVTEENLG---------LARVDPDSISSLKEEVTALETKLSGRTEELAQVRAALQQQ
EEEVKAREQRIQELEYTVAKLEEKLRQEDAKDVQ----------GQTDAVVSTDPFQ-GP
FATGLCDQSIRVQLPGITEPESWGGRGGEDGPLLRQDSHKQGDQSPVERAPPP-QLSLPQ
GPETV--LPSSLRSYPSTELRI--EEAGSAQQ-GG--PQEGAADLAGGAGGSSPSTS---
-------GKTPSAEKEE-ARAEAPGKERPERPPRSPT-DATIGQYVK--KIQEL-LQEQW
-SCL-EHGYPELASAIRQPASKLSSIQSQLLSSLNLLLSAYSAQAPPP--KEP--PAPS-
----ASPPLEISPSTSLKSIMKKKDYGFRAGGN--GTKKNLQFVGVNGG-----------
YETTSSE-ETSGEDSSP----EDLSDSEAEKKCDSPEHKQ--GKDAHRRDEAGQGIPEGT
-----HNAGRQRGPEE-----ETPHPKAERYKPSEEFLTACHAL-SQHLPEIE---TTTD
QLLRQSLNTINQEWFRISSRKSSSPAVVA-TYLRGVQPHSPHLLKLLVNLADG

PF00023 // ENSGT00530000063448_2_Domain_1 (1014, 1040)

NGNTALH
YSVSHSNFSIVKLLLETGACSVDHQNK--AGYTAVMITPLASAETDEDMAVVWKLLREGN
V--NIQATQG

PF00023 // ENSGT00530000063448_2_Domain_3 (1091, 1121)

GQTALMLGVSHDREDMVRALLSCQADVNLQ

ENSGT00530000063448_2_Linker_3_4 (1121, 1123)

DH

PF00023 // ENSGT00530000063448_2_Domain_4 (1123, 1148)

DGSSALMLACHRGNADMV
RLLLAHPTCDSSLTDKAGRTALSIVLKSP---AHVEIAGLLRAHAEQGRSLGP------

-------------------------------------------MEKTDA-KDQSCQGD-E
EKDPPKRH

PF12075 // ENSGT00530000063448_2_Domain_0 (69, 107)

PYSVETPYGFHLDLDFLKYVDDIEKGNTIKRIPIHRRS

ENSGT00530000063448_2_Linker_0_1 (107, 1014)

KQAKFSTLPRNFSL
PDSGARPPAAPL-PQNWSPVVP--------RKASLGTQEQTQSLPL-GNASQA--STSAS
EVSYHRRALLAEATRQLEAA-EPEDAEVTLGSGRPQLLRASSMPATLLHSRAS-EEPGLS
LGPPAPPALPPLQGEGSVCD--GTFGPAEGLAG-FHSSSPQAS----------------T
RI----PELVQEGAEPPEG--------T--VKAPNHLPLPGPPSSFQNVLVVLEDKEDEH
KARKAEV---VFSPGSPTPSPPPLPSPIPENELLLEEIELNISEIPPP-PPVEVDVRSIG
--IRVTEESLG---------LARVDPGSISSLKQQVSALEGELSGRTEELVQVRAALQQQ
EEEIKAREQRIRELEFTVAQLEGQLHQENTKDTQ----------GQTDAMVNTDPVH-GL
LTRESCDKGIEVNLLGSMESESWGHRGEENGLLWGPDGHKQGDQSPAEHV--P-QLSLPQ
GPERV--LTPSVHSFLSTELRI--EEAGTEQE-GG--PQG----GTRGAGGFPWGSD---
-------RKTPPAGREE-ANSNLPGKERPGRPPSSPT-DATIGQYVK--KIQEL-LQEQW
-NCL-EHGYPELASAIKQPASKLSSIQSQLLSSLNLLLSAYSAQAPPP--KEP--PASS-
----SSPPMEISPSTSLKSIMKKKDYGFRAGGN--GTKKNLQFVGVNGG-----------
YETTSSE-ETSGEDSSP----EDLSDSEAEKKCDGPDHRH--VKDAHLTCEVGQGIPEGS
-----CHAAQESGAGE-----EVPQSKAERYKPSEEFLNACQAL-SQHLPETG---TTTD
QLLRQSLNTISQEWFRVSSRKSSSPAVVA-SYLCEVQPHSPHFLKLLVNLADR

PF00023 // ENSGT00530000063448_2_Domain_1 (1014, 1047)

NGNTALH
YSVSHSNFSIAKLLLETGVCNVDHQNK--AGYTAVMITPLASAETNEDMAVVWKLLREGN
V--NIQATQGGQTALMLGVSHDREDMVQA

PF13857 // ENSGT00530000063448_2_Domain_4 (1110, 1165)

LLSCQADVNLQDHDGSSALMLACHHGNVDLV
RLLLAHPACDSSLTDKAGRTALSIALKSP---THMEIAGLLRAHAEQGRSLGL------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----MEKTDEISPSTSLKSIMKKKDYGFRAGGN--GTKKNLQFVGVNGG-----------
YETTSSE-ETSGEDSSP----EDLSDSEAEKKCDGPDHRH--VKDAHLTCEAGQGIPEGA
-----CHAAQESGAGE-----EVPHSKAERYKPSEEFLNACQAL-SQHLPETG---TTTD
QLLRQSLNTISQEWFRVSSRKSSSPAVVA-SYLCEVQPHS

PF12796 // ENSGT00530000063448_2_Domain_1 (1001, 1056)

PHFLKLLVNLADRNGNTALH
YSVSHSNFSIAKLLLETGVCNVDHQNK--AGYTAVMITPLASAETSEDMAVVWKLLREGN
V--NIQATQA--------------------------------------------------
-----------------GRTALSIALKSP---THMEIAGLLRAHAEQGRSLGL------

-------------------------------------------MEKTDA-KDQPSQGD-E
EKDPPKSH

PF12075 // ENSGT00530000063448_2_Domain_0 (69, 107)

PYSVETPYGFHLDLDFLKYVDDIEKGNTIKRIPIHRRA

ENSGT00530000063448_2_Linker_0_1 (107, 1014)

KQAKFSTLPRNFSL
PDSGARPHAPLP-HQHWSPAVP--------RKVSLGTQEQAQLPPL-GHGPQA--SASAG
EVSYHRRAVLAEASRQLEAA-GPEAAELASGSGRPQLLRASSMPATLLPDRAP-EEPSLS
LGPPTPPALPPLQGEGSLWD--GTFGPAEGLAG-FHSSSPQASTR---------------
---------VLEPGPEEAG--------P--PEPPTHLLLPGPPSSFQNALVVLEDGEEEH
QPREAEG---VFPAGSPPPSPPPLPSPIPESEFPLEEIELNISEIPPP-PPIEVDVRSIG
--IRVTEESLG---------LPDVTVGGVSSLRQRVSALEGELSGRTQELVQLRAALQQQ
EEETKTREQRIQELEGAVAQLEGQLSRENARDAR----------GQTDAMVNTDPVL-GL
LARESCDKSVEVNLLGIAEPEIWGARGEENGLPWGQDSDKQGDHSPGDHALSP-QQPLPQ
GPEKA--LT-SLHSCLSTELRI--EEAGSEQE-GG--PRGGAEGPAVGGTGGSSWSG---
-------GKTPPAGREE-ASSELPGKERAGRPPSSPT-DATIGQYVK--KIQEL-LQEQW
-SCL-EHGYPELASAIKQPASKLSSIQNQLLSSLNQLLSAYSAQAPPQ--EEP--PAPS-
-----SPPMEISPSTSLKSIMKKKDYGFRAGGN--GTKKNLQFVGVNGG-----------
YETTSSE-ETSGEDSSP----EDLSDSEAEKKCDGPEHRR--AKLAHPSCGAGQGVPEGT
-----HYASQDREPGE-----EVLHTKAERYKPSEEFLNACRAL-SQHLPETG---TITD
QLLRQSLNTISQEWFRISSRKSSSPAVVA-AYLLTVQPLSPCVLKLLINLADR

PF00023 // ENSGT00530000063448_2_Domain_1 (1014, 1047)

NGNTALH
YSVSHSNFAIAKLLLETGICNVDHQNK--AGYTAVMITPLASAETDEDMAVVWKLLREGN
V--NIQATQGGQTALMLGVSHDRQDMVQA

PF13857 // ENSGT00530000063448_2_Domain_4 (1110, 1164)

LLSCQADVNLQDHDGSSALMLACRHGNADLV
RLLLAHPACDSSLTDKAGRTALSMVLKTP---THMEIAGLLRAHTEQGRSLGQ------

-----------------------------------------------PAGEPAPPQGD-R
EKEPAKAH

PF12075 // ENSGT00530000063448_2_Domain_0 (69, 107)

PYSVETPYGFHLDLDFLKYVDDIEKGNTMKRIHVRRKA

ENSGT00530000063448_2_Linker_0_1 (107, 1014)

KQPKFSTLPRNFSL
PDSGARPPVAPA-PQALGLP-------------AKGSEE---------------------
------------LPGDQPAA-XAAEAEPDGGRGRPQLLRAASMPVTLLQAKAS-DEQSPG
CALPEPLPLPQTLEEGAFSE--GAFGPAEGFSD-PHSRSPLASTQPQAKELAGL----GP
GV----PNLVRDRPEH-----R-----DREEEPEDHICPPSQDPFPQDLPVVLESTEEEL
KAPEAEL---AATPGTPTPSPPPLPSPIPENGFPP-EIELNISEILPP-PPVEVNVRSIG
--VRVTEENLGLEPRTSEAA----AVTWASALRHQIAFLERELSKKTEELERARAALRQQ
GEELRSKELSIQELVGAVAQLEARLSPGRAP------------GSRSDASVNTDP-----
-VSEACDKSVLAQLPVHAEAG-----------PPPE------------------------
--GSP--RELPPQEXLSTELKI--EEQDAEQ-EGG--PQEGAHGGLGGSP----------
------------------SSLGTEGSSPGTEPRSSTP-DITIGQYVK--KIQEL-LHEQW
-TCL-EHGYPELANAIKQPASKLSSIQSQLVSSLNLLLSAYSAQSPPEQEGA-------S
SGP---PVPEISPSTSLKSIMKKRDYGFRAGGN--GTKKNLQFVGVNGG-----------
YETTSSE-ETSGEDSAS----EGCSDSEADKKGPGP--ERKPGRAAEQGQQPVPGTGEST
-----RSTGRESSTGGGEVAAAGTHHKSERYKPSEEFLSGC-HLLSRHLPEVWS-TT--D
QQLRQSLNAVSQEWFRVSSRKSSSPSIVA-AYLREFQPSDPDFLKLLVNLADD

PF00023 // ENSGT00530000063448_2_Domain_1 (1014, 1039)

NGNTALH
YSVSHSNFPIVKLLLETGVCDVDRQNK--AGYTAVMITPLASAETDEDMDVVGKLLKQGN
V--NIQAAQG

PF00023 // ENSGT00530000063448_2_Domain_3 (1091, 1121)

GQTALMLGVSHDRGDMVKALLTCRADVNLQ

ENSGT00530000063448_2_Linker_3_4 (1121, 1123)

DH

PF00023 // ENSGT00530000063448_2_Domain_4 (1123, 1149)

NGTTALMVATRHGHADMV
KLLLAHPGCDAALTDKAGHTALSMALTSP---AHGEIAELLWAHAEQGRSLGP------

-------------------------------------------VLCLPA-KDQSCQGD-E
EKDPPKRH

PF12075 // ENSGT00530000063448_2_Domain_0 (69, 107)

PYSVETPYGFHLDLDFLKYVDDIEKGNTIKRIPIHRRA

ENSGT00530000063448_2_Linker_0_1 (107, 1014)

KQAKFSTLPRNFSL
PDSGARPPAAPP-PQNWSPVVP--------RKASLGTQEQTQSLPL-GNASQA--STSAS
EVSYHRRALLAEATRQLEAA-EPEDAEVTLGSGRPQLLRASSMPATLLHSRAS-EEPGLS
PGPPAPPALPPLQGEGSVCD--GTFGPAEGLAG-FHSSSPQAS----------------T
RI----PELVQEGAEPPEG--------T--VKAPNHLPLPGPPSSFQNVLVVLEDKEDEH
KARKAEV---VFTPGSPTPSPPPLPSPIPENELLLEEIELNISEIPPP-PPVEVDVRSIG
--IRVTEESLG---------LARVDPGSISSLKQQVSALEGELSGRTEELVQVRAALQQQ
KEEIKAREQRIRELEFTVAQLEGQLHQENTKDTQ----------GQTDAMVNTDPVH-GL
LTRESCDKGIEVNLLGSMESESWGHRGEENGLLWGPDGHKQGDQSPAEHV--P-QLSLPQ
GPEQV--LTPSVHSFLSTELRI--EEAGTEQE-GG--PQG----GTRGAGGFLWGSD---
-------RKTPPAGREE-ANSDLPGKERQGRPPSSPT-DATIGQYVK--KIQEL-LQEQW
-NCL-EHGYPELASAIKQPASKLSSIQSQLLSSLNLLLSAYSAQAPPP--KEP--PASS-
----SSPPMEISPSTSLKSIMKKKDYGFRAGGN--GTKKNLQFVGVNGG-----------
YETTSSE-ETSGEDSSP----EDLSDSEAEKKCDGPDHRH--VKDAHLTFEAGQGIPEGA
-----CHAAQESGAEE-----EVPHSKAERYKPSEEFLNACQAL-SQHLPETG---TTTD
QLLRQSLNTISQEWFRVSSRKSSSPAVVA-SYLCEVQPHSPHFLKLLVNLADR

PF00023 // ENSGT00530000063448_2_Domain_1 (1014, 1040)

NGNTALH
YSVSHSNFSIAKLLLETGVCNVDHQNK--AGYTAVMITPLASAETNEDMAVVWKLLREGN
V--NIQATQG

PF00023 // ENSGT00530000063448_2_Domain_3 (1091, 1121)

GQTALMLGVSHDREDMVQALLSCQADVNLQ

ENSGT00530000063448_2_Linker_3_4 (1121, 1123)

DH

PF00023 // ENSGT00530000063448_2_Domain_4 (1123, 1151)

DGSSALMLACHHGNVDLV
RLLLAHPACDSSLTDKAGRTALSIALKSP---THMEIAGLLRAHAEQGRSLGL------

-------------------------------------------VLCLPA-KDQPSQGD-E
EKDPPKSY

PF12075 // ENSGT00530000063448_2_Domain_0 (69, 107)

PYSVETPYGFHLDLDFLKYVDDIEKGNTIKRIPIHRRA

ENSGT00530000063448_2_Linker_0_1 (107, 1014)

KPAKFSTLPRNFSL
PNGGARPQAALP-HQNWSPGVP--------RKVSLGTQEQTPSLPP-GSPPQA--TASRG
ELSYHRRALLAEATRQLEPAAP------EEGSGRPQLLRASSMPATLQQHR---------
---------PALQGEGPICD--GAFGPAEGFTG-VGSSTLQAS-----------------
PP----PQLVREGAEPTEG--------N--LKTPDHLSLPEPPPSFQNALGVLADAEDEP
ETRGSE----VFTPGPPTPSPPPLPSPVPESELPLQEIELSISELPPP-PPVAVDVRSVG
--VTVSENGLG---------LAGC-VGSVPSLQQQVSALEGELSGKTEELVRVRAALQQR
EEEARAKEQKIQELEHAVAQLEGKLRQEAARDNQ----------GRTDATVNTDPVG-GL
WTRELCDKGIEVSLLHVTESESPGAQAGQNGLPWGQNRPRQGDQSPGEHALLS-ALPVLQ
GPGWV---PSSPHSCLSTELRI--EEPGPEQE-GG--PQGGPEGLAWGAGASSWSSD---
-------RKSPPAGREE-ASSDLPGKESLGRPPSSPT-DATLGQYVK--KIQEL-LQEQW
-NCL-EHGYPELASAIRQPASKLSSIQNQLLSSLNLLLSACSAQAAPQ--REPPAPT-S-
----SSPPMEISPPTSLKSIMKKKDYGFRAGGN--GTKKNLQFVGVNGG-----------
YETTSSE-ETSGEDSSP----EDLSDSEAEKKGDSLEDRQ--TKAVPPGCEAGQGVP---
------HAGQDSGPGD-----EVPHSKAERCKPSEEFLNACRTL-SQHLPETG---TTAD
QLLRQSLNTISQEWFRISSRKLSSPAVVA-AYLRGVQPHSSHFLKLLVNLADR

PF00023 // ENSGT00530000063448_2_Domain_1 (1014, 1041)

NGNTALH
YSVSHSNFSIAKLLLDTGTCLLFIFNR--LWYKKFYITNIYKTQQEQGMNVIFHLNNNDN
CNRDLPGTQG

PF00023 // ENSGT00530000063448_2_Domain_3 (1091, 1121)

GQTALMLGVSHDREDMVRALLSCQADVNLQ

ENSGT00530000063448_2_Linker_3_4 (1121, 1124)

DHE

PF00023 // ENSGT00530000063448_2_Domain_4 (1124, 1151)

GASALMLACHHGNSDLV
RLLLAHPACDSSLTDKAGRTALSIVLKSP---THMEIAALLQAHGEQGRSLGP------

-------------------------------------------MEKTDA-KDQSFLQN-E
EKDAPKSHPYSVETPYGFHLDLDFLKYVDDIEKGNTIKRIPIHRRAKPAKFSTLPRNFSL
PDSGARPHAALP-LQSWSPAGS--------RKVLLGTQEHTQSLAL-GDPLQA--SAGNS
AVSYHRKALLAEASRQGEAP-TPE----NTESARPHLLRASSMPATLLQSRAS-EESSLS
SGPPIAPALPPLPAESSVCD--ITLGSLEGFAG-VHSSSPGAI----------------T
RI----SELVLEGAGTTKS--------D--MTAVNHLSFPSPPSPVTSTLVVLEDAEDKT
R--EAEM---VFTPSSLTPSPPPLPSPIPENELPLEEIELSISEIPPP-PPIEVEVQSIG
--IWVTEESLG---------LARLDHGSISSLKQQLLDLESELYGRTKELAQVRAALQQQ
EEEARTREQRIQELECAVAQLEDQLSQGSTRDAP----------GQTDAAMNTDPLQ-GL
LTKESCDKSIGANLLGITDSENWGVRGEETVLLWGPDSQFEGDQPPAKRVLPS-QLSLPQ
GPEKV--LASPLHSCLSTELRI--EEGGFELE-GS--PQGGAEGLAWEARGCPQSND---
-------REAPPAQREE-VSSELPGKEHPGRPPSSPV-DATIGQYVK--KIQEL-LQEQW
-NCL-EHGYPELASAIKQPASKLSSIQSQLLSSLNLLLSAYSAQAPPQ--KEPP----A-
----SSPPTEISPSTSLKSIMKKKDYGFRAGGN--GTKKNLQFVGVNGG-----------
YETTSSE-ETSGEDSSP----EDLSDNEAERKHDGPEHLR--ARNAHSSSEPGKGAPGDT
-----SSAGQERGPGE-----EAPHAKAERDQPSEEFLTACRAL-SQHLSETG---TITD
GLPKQSLNAISQEWFRVSSRKSSNPAVVA-AYLLGVQPLSPHLLKLLVNLADR

PF00023 // ENSGT00530000063448_2_Domain_1 (1014, 1047)

NGNTALH
YSVSHANFPVVKLLLDTGVCNVDHQNK--AGYTAVMITPLALAETDEDMAVVWKLLREGN
V--NIQATQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXAGRTALSITLQSP---GLVEIAELLRAHAEQGRSLEM------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------MKKKDYGFRAGGN--GTKKNLQFVGVNGG-----------
YETTSSE-DTSGEDSSP----EDLSESEVEKKCDGPEPRQ--GRDAHPSCEPGQAVSQGI
-----LSTPQEDGPGE-----EVSHPKTERCKPSEEFLNACRTL-SQHLPETG---TTPN
QLLRQSLNTMSQEWFRVSSRKSSSPAVVA-AYLLGIQPH

PF12796 // ENSGT00530000063448_2_Domain_1 (1000, 1057)

SPHLLKLLVNLADRNGNTALH
YSVSHSNFAIVKLLLDTGVCNVDHQNK--AGYTAVM

ENSGT00530000063448_2_Linker_1_4 (1057, 1110)

ITPLASAETDEDMAVVWKLLREGN
V--NIQATQGGQTALMLGVSHDREDMVQA

PF13857 // ENSGT00530000063448_2_Domain_4 (1110, 1163)

LLSCQADVNLQDHDGSSALMVACHHGNADLV
RLLLAHPACNSSLTDKAGHTALSITMKSPTSSAHVEIAELLQAHSERGRSLGL------

-------------------------------------------MEKTDA-KDQSSQGD-E
EKDPPKSH

PF12075 // ENSGT00530000063448_2_Domain_0 (69, 107)

PYSVETPYGFHLDLDFLKYVDDIEKGNTIKRIPIHRRA

ENSGT00530000063448_2_Linker_0_1 (107, 1014)

KQAKFSTLPRNFSL
PDSGARPPAAPP-LQNWSPMVP--------RKASLGTQEQNQSPPL-GNAPQA--STSRS
EVSYHRRALLAEATRQLEAA-EPEDAELTFGIGRPQLLRASSMPATLLHSRAS-EEPGLS
LGPPAPPALPPLQGEGSACD--GSFEPAEGLAG-FHSSSPRAS----------------T
RI----PELVQEGAEPPEG--------M--VKVPNHLPLPGPPFSFQNALVVLEDKEDEH
NAREAEV---LFTPDSPTPSPPPLPSPIPENELLLEEIELNISEIPPP-PPVEVDMRSIG
--IRVTEESLG---------LARVDPGSISSLKQQVLALEGELSGRTEELAQVRAALQQQ
EEEIKAREQRIRELEFTVAQLEGQFHQENAKDTQ----------GQTDAMVNTDPVH-GL
LTRESCDKGIEVNLLGSMESESWGPRGEENGLLWGPDGHKQGNQSPAERVLLP-QMSLPQ
GPEQV--LTSSVHSFLSTELRI--EEAGTEQE-GG--PQG----GTRGAGGFLWGSD---
-------RKTPPAEREE-ASSNLPGKEHPGRPPSSPT-DATIGQYVK--KIQEL-LQEQW
-NCL-EHGYPELASAIKQPASKLSSIQSQLLSSLNLLLSAYSAQAHPP--KEP--PASS-
----SSPPVEISPSTSLKSIMKKKDYGFRAGGN--GTKKNLQFVGVNGG-----------
YETTSSE-ETSGEDSIP----EDLSDSEAEKKCDGPDHKH--VKDAHLTCEAGQGIPEGT
-----CHAAQESGPGE-----EVPHSKAERYKPSEEFLNACQAL-SQHLPETG---TTTD
QLLRQSLNTISQEWFRVSSRKSSSPAVVA-SYLHEVQPHSPHFLKLLVNLADR

PF00023 // ENSGT00530000063448_2_Domain_1 (1014, 1047)

NGNTALH
YSVSHSNFPIAKLLLETGVCNVDHQNK--AGYTAVMITPLASAETNEDMAVVWKLLREGN
V--NIQATQGGQTALMLGVSHDREDMVQA

PF13857 // ENSGT00530000063448_2_Domain_4 (1110, 1165)

LLSCQADVNLQDHDGSSALMLACHHGNVDLV
RLLLAHPACDSSLTDKAGRTALSIALKSP---THMEIAGLLRAHAEQGRSLGL------

-------------------------------------------VLCLPA-KDQSFPGNEK
KKDPPKSH

PF12075 // ENSGT00530000063448_2_Domain_0 (69, 107)

PYSVETPYGFHLDLDFLKYVDDIEKGNTIKRIPIHRRA

ENSGT00530000063448_2_Linker_0_1 (107, 1014)

KQAKFSTLPRNFSL
PDSGARPHVALP-HQNWSPGVS--------RKALLGTREQTQSLPL-GDPPQA--SASSS
ELSYHRKALLAEAARQLEAA-APENAELAPGGARPHLLRASSMPATLLQSRAP-EELSLS
SAPPIPPAFPPPPGEGSVCD--GTLGPVEGFAA-VHSFSPGVS----------------T
QI----SELVLEAAEPPEG--------E--MKAVSHLPLPSPPSSFPMALVVLEDAEDKT
RD--AD---TVFTPSSLTPSPPPLPSPIPESELPLEEIELNISEIPPP-PPVEVEVRSIG
--IRVTEESLG---------LAGMDPGSISSLKQQLSALEGELSGRTKELAQVRAALQQQ
EEETKAREQRIQELECAVAQLEGKLSQGSTREAE----------GQTDATVNTDPLH-GL
VARESCDKSIGVNLVGIMDSESWGVRGEENGLPWGQDSHSQG---LAERVPPP-QLSLPQ
GPKRV--LTSPLHSCLSTELRI--EEAGSEQE-GD--PRGGAEGLAEGARGSSWSSD---
-------GEAPPAGREE-TSSELPGKERPGRPPSSPT-DATIGQYVK--KIQEL-LQEQW
-NCL-EHGYPELASAIKQPASKLSSIQSQLLSSLNLLLSAYSAQAPAQ--KEPPAP----
----SSPPVEISPSTSLKSIMKKKDYGFRAGGN--GTKKNLQFVGVNGG-----------
YETTSSE-ETSDEDSTP----EDLSEGEAEKKRDGPEHRR--ARDAHPSCEPGQGVPEDA
-----SNAGQERGPGE-----EAPHAKPERYKPSEEFLIACRAL-SQHLPETG---TLTD
GLPRQSLNAISQEWFRVSSRKSSSPAVVA-AYL-GVQSLSPRLLKLLVNLADR

PF00023 // ENSGT00530000063448_2_Domain_1 (1014, 1040)

NGNTALH
YSVSHANFPVVKLLLDTGVCNVDHQNK--AGYTAVMITPLASAETDEDMAVVWKLLREGN
V--NIQATQG

PF00023 // ENSGT00530000063448_2_Domain_3 (1091, 1121)

GQTALMLGVSHDREDMVQALLSCQADVNLQ

ENSGT00530000063448_2_Linker_3_4 (1121, 1124)

DHE

PF00023 // ENSGT00530000063448_2_Domain_4 (1124, 1150)

GSSALMLACHHGNADLV
RLLLAHPACDSNLTDKAGRTALSIALNSA---ALVEMAGLLRAHAEQGRSLGL------

------------------------------------------------A-KDQSCQGD-E
EKDPPKRH

PF12075 // ENSGT00530000063448_2_Domain_0 (69, 107)

PYSVETPYGFHLDLDFLKYVDDIEKGNTIKRIPIHRRS

ENSGT00530000063448_2_Linker_0_1 (107, 1014)

KQAKFSTLPRNFSL
PDSGARPPAAPP-PQNWSPVVP--------RKASIGTQEQTQSLPL-GNASQA--STSAS
EVSYHRRALLAEATRQLEAA-EPEDAEVTLGSGRPQLLRASSMPATLLHSRAS-EEPGLS
LGPPAPPALPPLQGEGSICD--GTFGPAEGLAG-FHSSSPQAS----------------T
RI----PELVQEGAEPPEG--------T--VKAPNHLPLPGPPSSFQNVFVVLEDKEDEH
KARKAEV---VFSPGSPTPSPPPLPSPIPENELLLEEIELNISEIPPP-PPVEVDVRSIG
--IRVTEESLG---------LARVDPGSISSLKQQVSALEGELSGRTEELVQVRAALQQQ
EEKIKVREQRIRELEFTVAQLEGQLHQENTKDTQ----------GQTDAMVNTDPVH-GL
LTRESCDKGIEVNLLGSMESESWGHRGEENGLLWGPDGHKQGDQSPAEHV--P-QLLLPQ
GPERV--LTPSVHSFLSTELRI--EEAGTEQE-GG--PQG----GTRGAGGFPWGSD---
-------RKTPPAGREE-ANSDLPGKERPGRPPSSPT-DATIGQYVK--KIQEL-LQEQW
-NCL-EQGYPELASAIKQPASKLSSIQSQLLSSLNLLLSAYSAQAPPP--KEP--SASS-
----SSPPMEISPSTSLKSIMKKKDYGFRAGGN--GTKKNLQFVGVNGG-----------
YETTSSE-ETSGEDSSP----EDLSDSEAEKKCDGPDHRH--VKDAHLTCEAGQGIPEGT
-----CHAAQESGAGE-----EVPQSKAERYKPSEEFLNACQAL-SQHLPETG---TTTD
QLLRQSFDTYSVN-------EWSAPCLWW-PLLCEVQPHSPHFLKLLVNLADR

PF00023 // ENSGT00530000063448_2_Domain_1 (1014, 1047)

NGNTALH
YSVFHSNFSIAKLLLETGVCNVDHQNK--AGYTAVMITPLASAETNEDMAVVWKLLREGN
V--NIQATQGGQTALMLGVSHDREDMVQA

PF13857 // ENSGT00530000063448_2_Domain_4 (1110, 1165)

LLSCQADVNLQDHDGSSALMLACHHGNVDLV
RLLLAHPACDSSLTDKAGRTALSIALKSP---THMEIAGLLRAHAEQGRSLGL------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------MKKKEYGFRAGGN--GTKKNLQFVGVNGG-----------
YETTSSE-ETSGEDSSP----EDLSDSEVEKK--CDGPKSRQDQEIDPSCKAGHGVPKDT
-----QNKGQEMEPVD-----EVSHPKAERYKPSEEFLDACQAL-SQHLPETE---TTTD
QLLRQSVNTISQEWFRVSSRKLSSPAVVA-AYLLEARR

PF13637 // ENSGT00530000063448_2_Domain_1 (999, 1035)

HPPRLLKLLVNLADRSGNTALH
YSVSHSNFAIVKLLLGTGVCNVDHQNK--AGYTPVMITPLASAETKEDMAVVWKLLREGN
V--NIQATQGGQTALMLGISHDREDMVQA

PF13857 // ENSGT00530000063448_2_Domain_4 (1110, 1162)

LLSCQADVNLQDHEGASALMLACRQGNVDLV
RLLLAHPACNSSLTDKAGRTALSTVLNSP---THMEIAGLLRAHAEQGRPLGH------

-------------------------------------------MEKTEARDQAPSQRD-G
EKEAPQSH

PF12075 // ENSGT00530000063448_2_Domain_0 (69, 107)

PYSVETPYGFHLDLDFLKYVDDIEKGNTIKRIHIHRKAKQPKFSTLPRNFSL
PDSGARPHAAPP-HPPWTSAFS-----GLPRKTSLGSEE------PPGDPAQP--LAGGA
EISYRRRALLAETIRQAEAP-PCAEAELDGGRGRPQLLRASSMPATLLQHKLS-DEQSLS
PGLTE----AQPREEDGLSE--AAFGPVEDFPD-PHSSGLQASSQPQMEELAAL----VP
GI----PDLVQDTPELG----------DQDKGLQSHSCPLSPAPFPQDLPVVLESVEEEP
KAPEVEL---GTPPGTPTPSPPPLPSPIPENEFPS-EMELNISEIPPP-PPVEMDMRSSG
--LGVPEESLGLGPSDP--------------LKQRVSALEGQLSARTEELAKLRALLRQQ
EDELQSKERSIRELVGTVAELERRLGRSGA------------------------------
----VCDKGVPVSPPVSP---------------------------------RP-ASPPPQ
EPDVS--PPTPSPSYLCTELKI--EEQVPEV---G--GPGGSP-----------------
------------------SSVGTGTSSPGTEQRGSPP-DASIGQYVK--KIQEL-LHEQW
-TCL-EHGYPELANAIKQPASKLSSIQSQLVSSLNLLLSAYSAQSPPEPER-------PP
GRP---PPPEISPSTSLKSIMKKRGYGFRAGGN--GTKKNLQFVGVNGG-----------
YETTSSE-ETSGEDSAS----EAASDGEPEKKGDGP--ELKLGRAAEGSQQMVQGPAEGA
-----GSSA-----SGGEGAAAGAHHKSERFQTLSTVLSSCKAWTQSIPQDTGG-HQSIL
VFQRQSLNAVSQEWFRVSSRKSSSPSVVA-AYLSEFQPSDPHFLKLLVNLADDNGNTALH
YSVSHSNFPVVKVLLETGVCDVDRQNK--AGYTAVMITPLASAETDEDMSVVGKLLKQGN
V--NIQAAQG

PF00023 // ENSGT00530000063448_2_Domain_3 (1091, 1121)

GQTALMLGVSHDRGHMVKALLSCGADVNLQDHEGTSALMAAARHGHADMV
RLLLAHPDCDAALTDKAGRTALSTALASA---GHGEIAELLCAHAEQRRSIGP------

------------------------------------------------------------
---------YSVETPYGFHLDLDFLKYVHDIEKGNTIKRIHIHRRAKQSKFSTLPRNFSV
PDNGSQSYISSS-SRTWSPTSF-----K--------SDAQ-GNIAPASDSSLR--LRYIH
DLNYRKKENVCDTQKHIGD---IVSEDINRCADRPQFVRASSMPAALPQSTGHYEQNKY-
LKFP--------QSVNSYSE--STTQCLEGSHH-KGSEDQTAVAL---------------
-------KRIKDLEEQLQTV-------------TEH-------------KKTISELEGEN
SKLNAQL---KS-----------ISELLTSNRMENENVDLNISESEAQPEAI--------
---------TGNGGNDGDLGCTSVSHSIFLAIKQQITEFIEHFDDSTRDCHNLREILERQ
KEEMNAKDLHIIELKNTIDTLEEMIRTRQKDDV-----------EYKDIAVNTEQPPKDE
QKGNSFSDNISFVTQ-SVESDNMTTNLKQTSFERNELCLLIDSDH------PA-VI---A
--GPE--AQSHITSNIDTEQRL--DNSDMN--------------ITEAMPSCITVET---
-------EHLDAHISQS-HNLNNPESVVCITEDQTPT-DASVGQYVK--RIQDL-LQEQW
-TCL-EHGYPDLANAIRQPASKLSSIQGQLVNSLNLLSSAYSAQAAPAKAP---------
LLAKSFPPTEAVPRSSLKSIMKKKNINSRMGSSEVQAKKNLQFVGVNGG-----------
YETTSSE-DSSSSEEFCGTGKNDVSDSGEAQASSDDKIETVLMPVSE-VKEIAQEDPEPM
-----VPSQQVTQ-R----KRKMPERFVEECTVSDAFRSECQKL-SKHLAGLQG-TT--D
NQLRQTLYTVCQEWFRVSSQKTSSSDLVT-VYLEELRSICPQLLQMVVNMSDE

PF00023 // ENSGT00530000063448_2_Domain_1 (1014, 1047)

NGNTALH
YSVSHSNFSIVKLLLKTGVCEVDYQN

ENSGT00530000063448_2_Linker_1_2 (1047, 1050)

K--

PF00023 // ENSGT00530000063448_2_Domain_2 (1050, 1088)

AGYTPVMLTVLASTETDEDMEVVLTLLTEGN
V--NLCA

ENSGT00530000063448_2_Linker_2_3 (1088, 1090)

TQ

PF00023 // ENSGT00530000063448_2_Domain_3 (1090, 1122)

GRQTSLMLAVSHGRLDMVTVLLNCGADVNLQDEDGETALMMACRLGNMDLV
KLLLAQPGCDTELSDK

PF00023 // ENSGT00530000063448_2_Domain_6 (1157, 1181)

VGNTALSIVLNS----AHSEIAEFLQAHTEHRRSRSA------

-------------------------------------------MEKTDA-KDQSSQGD-E
EKDPLKSH

PF12075 // ENSGT00530000063448_2_Domain_0 (69, 107)

PYSVETPYGFHLDLDFLKYVDDIEKGNTIKRIPIHRRA

ENSGT00530000063448_2_Linker_0_1 (107, 1008)

KQAKFSTLPRNFSL
PDSGARPPAAPP-LQNWSPVVP--------RKASLGTQEQNQPPPL-GNAPQA--STSRS
EVSYHRRALLAEATRQLEAA-EPEDAELTFGSGRPQLLRASSMPATLLHSRAS-EEPGLS
LGLPAPPALPPLQGEGSVCD--GTFEPAEGLAG-FHSSSPRAS----------------T
RI----PELVQEGAEPPEG--------M--VKVPNHLPLPGPPFSFQNALVVLEDKEDEH
NAREAEV---LFTPGSPTPSPPPLPSPIPENELLLEEIELNISEIPPP-PPVEVDMRSIG
--IRVTEESLG---------LARVDAGSISSLKQQVSALEGELSGRTEELAQIRAALQQQ
EEEIEAREQRIRELEFTVAQLEGQFHQENAKDTQ----------GQTDAMVNTDPVH-GL
LTRESCDKGIEVNLLGSMESESWGHRGEENGLLWGPDGHKQGNQSPAERVLLP-QLSLPQ
GPEQV--LTSSVHSFLSTELRI--EEAGTEQE-GG--PQG----GTRGAGGFLWGSD---
-------RKTPPAGREE-ASSNLPGKEHRGRPPSSPT-DATIGQYVK--KIQEL-LQEQW
-NCL-EHG--ELASAIKQPASKLSSIQSQLLSSLNLLLSAYSAQAHPP--KEP--PASS-
----SSPPVEISPSTSLKSIMKKKDYGFRAGGN--GTKKNLQFVGVNGG-----------
YETTSSE-ETSGEDSTP----EDLSDSEAEKKCDGPDHKH--VKDAHLTCEAGQGIPEGT
-----CHAAQESGPGE-----EVPHSKAERYKPSEEFLNACRAL-SQHLPETG---TTTD
QLLRQSLNTISQEWFRVSSRKSSSPAVVA-SYLHEVQPHSPHFLKLL

PF13637 // ENSGT00530000063448_2_Domain_1 (1008, 1035)

VNLADRNGNTALH
YSVSHSNFSIAKLLLETGVCNVDHQNK--AGYTAVMITPLASAETSEDMAVVWKLLREGN
V--NIQATQGGQTALMLGVSHDREDMVQA

PF13857 // ENSGT00530000063448_2_Domain_4 (1110, 1165)

LLSCQADVNLQDHDGSSALMLACHHGNVDLV
RLLLAHPACDSSLTDKAGRTALSIALKSP---THMEIAGLLRAHAEQGRSLGL------

-------------------------------------------MEKADA-KDQSSRGD-E
EKDPAKSH

PF12075 // ENSGT00530000063448_2_Domain_0 (69, 107)

PYSVETPYGFHLDLDFLKYVDDIEKGHTIKRIPIHRRA

ENSGT00530000063448_2_Linker_0_1 (107, 1008)

KQAKFSTLPRNFSL
PDSGARIHAARP-QQNWSPVVP--------RKISLGTQEQSRSLPR-ADVPQA--SVYGS
ELSYHRKALLAEDTGQAEAG-ALED----GGSGRPLLLRASSMPATLLQNRAP-DESSLT
PVPST-----LLQGEGSVCD--DTFDPAEGFTA-FQA-----STQSTDRELGEL----EP
AI----PELVMEGAEPEEG--------A--IKASIHLSQPGPPSSVQNVPMVVGDVEIQQ
QARKAEA---VLTPGSSTPSPPPLPSPIPESELSLEEIELNISEIPPP-PPIELDVRSIG
--IRVTEESLG---------LVGTDTNSISSLRNQVLALEDKLSGRTEELAHIRAALTRQ
QEETKARERRIQELECTVAQLEEKLSQEKASNAL----------DQTDATVNTDPLL-EL
IPKDSCDKNIGVNLMRIPDPECWASGAEKNGFPWVQSSHKQGHQSPEEPVLPP-QLSLSR
GPEQV--LASSLCSCLSMELRI--KEDVSEQE-RG--PQVGAEDLGRVTGASPWSSG---
-------RESASVIREE-ASSEFPGAELPGRPASSPQ-DATIGQYVK--KIQEL-LHEQW
-NCL-EHGYPELASAIKQPASKLSSIQNQLLSSLNLLLSAYSAQAPEQ--KEPPAPPS--
--STPPPPPEISPSTSLKSIMKKKDYGFRAGGN--GTKKNLQFVGVNGG-----------
YETTSSE-ETSGEDSSP----EDVSDSETEKKRDCSEPTQ--ERDMHAACEAEQGVPEGT
-----SNSGQTSGPGE-----EGSHLRPERCKPSEEFLTACRAL-SQHLPETG---ATTQ
QLLRQSLNTISQEWFRVSSRKLSSPAVVA-AYLLEVQPYSSHLLKLL

PF13637 // ENSGT00530000063448_2_Domain_1 (1008, 1035)

VNLADRSGNTALH
YSVSHSNFAIVKLLLDTGVCDVDHQNK--AGYTAVMITPLASAETKEDMAVVWKLLREGN
V--NIQATQGGQTALMLGVSHDREDMVQA

PF13857 // ENSGT00530000063448_2_Domain_4 (1110, 1164)

LLSCQADVNLQDHDGSSALMLACHQGNADLV
RLLLAHPACNSSLTDKAGQTALSIVLNSP---AHVEIAELLQAHSEQGRSLGPERLQKS

-------------------------------------------------------QRD-E
ERGSSKSC

PF12075 // ENSGT00530000063448_2_Domain_0 (69, 107)

PYSVETPYGFHLDLDFLKYVDDIEKGNTIKRVPIHRRA

ENSGT00530000063448_2_Linker_0_1 (107, 1014)

KQAKFSTLPRNFSL
PSSGVRPPAALL-QQSWSPAV--------PRKVSLGLQEQTQPQVPQSSPPQA--WAGGS
KLSHPRKALLAEATGQG------EDAVPSCASARPQLLRASSMPATLLPSRAL-------
EGPPTPPAPPPLQDTGGTWD--EAFSPRPGASA-ANTA----------------------
----------KDLGDQVLGIPKESELPTGESQALDYPCPPGLPPPFQSVSVVPEDLGAEG
QKEGTQL---ASTPGSSTPSPPPLPSPIPESELALGDIELNISELPPPPPPLEMAVQSVG
--VRVTEEALGLDGS----------------LGQQLWALQDELASRVEELASIRVTL---
----EAKEQRILELESTVAQLEEKLSQDAQ--DP---------QGHIDAAVGTDPLC-DL
HRVETHDKGVGVTFLSPADSGNQGV-LGELGNLL-----WQ-------------------
-SCPV--PASPVHSCLSTELRI--EEPASLGQEAV--EGLAAEGTLG--------SD---
-------GEAASVAREE-AGSQHP----AGLPG-SSP-DAALGQYVR--KIQEL-LQEQW
-SCL-EHGYPELASALRQPASRLSSIRGQLLSSLSLLLSACAAQGPQQEPAGHPAPSPPA
PTP---SAPELSPPTSLKSIMKKRDCGFRAGGN--GARKSLQFVGVNGG-----------
YETTSSE-ETSGEDSSP----EDLSDSEAEKKCSDP--ECLRDGDTHTEQ----ARPEAT
-----QSTARERF-----------PAVLSRCKPSEEFLSACRAL-GQHPLEA-V-AT--D
PLLGPSLNTVSQEWFRVSSRKSSSPAVVA-AYLLEVQPLSPHLLKLLVNLADG

PF00023 // ENSGT00530000063448_2_Domain_1 (1014, 1046)

NGNTALH
YSVSHSNFPIAKLLLDTGVCAVNRQNK--AGYTAVMITPLASAETTEDMAVVWQLLREGN
V--NVQATQGGQTALMLGVSHDRGDMVHA

PF13857 // ENSGT00530000063448_2_Domain_4 (1110, 1147)

LLHCQADVNLQDHEGATALMLACRHGNTDLV
RLLLAQPSCDSSLADK-------------------------------------------

-------------------------------------------MEKTDA-KDQSCQGD-E
EKDPPKRH

PF12075 // ENSGT00530000063448_2_Domain_0 (69, 107)

PYSVETPYGFHLDLDFLKYVDDIEKGNTIKRIPIHRRS

ENSGT00530000063448_2_Linker_0_1 (107, 1014)

KQAKFSTLPRNFSL
PDSGARPPAAPP-PQNWSPVVP--------RKASLGTQEQTQSLPL-GNASQA--STSAS
EVSYHRRALLAEATRQLEAA-EPEDAEVTLGSGRPQLLRASSMPATLLHSRAS-EEPGLS
LGPPAPPALPTLQGEGSVCD--GTFGPAEGLAG-FHSSSPQAS----------------T
RI----PELVQEGAEPPEG--------T--VKSPNHLPLPDPPSSFQNVLVVLEDKEDEH
KARKAEV---VFSPGSPTPSPPPLPSPIPENELLLEEIELNISEIPPP-PPVEVDVRSIG
--IRVTEESLG---------LARVDPGSISSLKQQVSALEGELSGRTEELVQVRAALQQQ
EEEIKAREQRIRELEFTVAQLEGQLHQENTKDTQ----------GQTDAMVNTDPVH-GL
LTRESCDKGIEVNLLGSMESESWGHRGEENGLLWGPDGHKQGDQSPAEHV--P-QLSLPQ
GPERV--LTPSVHSFLSTELRI--EEAGTEQE-GG--PQG----GTRGAGGFPWGSD---
-------RKTPPAGREE-ANSNLPGKERPGRPPSSPT-DATIGQYVK--KIQEL-LQEQW
-NCL-EHGYPELASAIKQPASKLSSIQSQLLSSLNLLLSAYSAQAPPP--KEP--PASS-
----SSPPMEISPSTSLKSIMKKKDYGFRAGGN--GTKKNLQFVGVNGG-----------
YETTSSE-ETSGEDSSP----EDLSDSEAEKKCDGPDHRH--VKDAHLTCEVGQGIPEGS
-----CHAAQESGAGE-----EVPQSKAERYKPSEEFLNACQAL-SQHLPETG---TTTD
QLLRQSLNTISQEWFRVSSRKSSSPAVVA-SYLCEVQPHSPHFLKLLVNLADR

PF00023 // ENSGT00530000063448_2_Domain_1 (1014, 1047)

NGNTALH
YSVSHSNFSIAKLLLETGVCNVDHQNK--AGYTAVMITPLASAETNEDMAVVWKLLREGN
V--NIQATQGGQTALMLGVSHDREDMVQA

PF13857 // ENSGT00530000063448_2_Domain_4 (1110, 1165)

LLSCQADVNLQDHDGSSALMLACHHGNVDLV
RLLLAHPACDSSLTDKAGRTALSIALKSP---THMEIAGLLRAHAEQGRSLGL------

--------------------------------------------GLRVD-GDQPSQGD-E
EKDPPKSH

PF12075 // ENSGT00530000063448_2_Domain_0 (69, 107)

PYSVETPYGFHLDLDFLKYVDDIEKGHTIKRIPIHRRA

ENSGT00530000063448_2_Linker_0_1 (107, 1002)

KQAKFSTLPRNFSL
PDSGARTYAAPP-QQNWSPVVP--------RKISLGIQEQSQSLPL-GDVPQA--SGHGS
ELSYHRKVLLAEGMRQVEAG-ALED----GGSGRPQLLRASSMPATLLQNRAP-DEPSLT
SGPSTLLALPLLQGEGSACD--RAFDPAEGFTG-FQA-----STQSTDRGLGEL----EP
AI----PELVWEGVEPEEG--------D--IKASSHLSQPGSPSSVQNVPMVLENMGIQH
QARKAEV---VLTPGSSTPSPPPLPSPIPENELSLEEIELNISEIPPP-PPIEVDVRCIG
--IQVTEESLG---------LAGTDTNSISSLKNQFSALEDKLSGRTEELTQVRAALAWQ
QEETKAREQRIQELECTVAQLEEKLSQEKASDAL----------DRTDATVNTDPLL-EL
IPRESCDKNIGVNLLRTPDPECWTSTAERNGFPWVQNSHKRGHQSPEGPVLPPTQLSLSR
GPEQV--LASSLCSCLSMELRI--EEDVSEQE-RG--SQVGAEDLSRVTGASSWSST---
-------RESASVIREE-ASSELPGAERPGRPASSPQ-DATIGQYVK--KIQEL-LHEQW
-NCL-EHGYPELASAIKQPASKLSSIQNQLLSSLNLLLSAYSAQAPEQ--KEPPAQPS--
--ATPPPPPEISPSTSLKSIMKKKDYGFRAGGN--GTKKNLQFVGVNGG-----------
YETTSSE-DTSGEDSSP----EDVSDSETEKKRDCSEPRQ--GRDTHPPREAGQDVPEGT
-----GNSGQTSGSGE-----EVSHLRPERCKPSEEFLNACQAL-SQHLPETG---ATTK
QLLRQSLNTISQEWFRVSSRKLASPAVVAA-YLLEVQ-PHS

PF13637 // ENSGT00530000063448_2_Domain_1 (1002, 1035)

HLLKLLVNLADRSGNTALH
YSVSHSNFAIVKLLLDTGVCNVDHQNK--AGYTAVMITPLASAETKEDMAVVWKLLREGN
V--NIQATQGGQTALMLGVSHDREDMVQA

PF13857 // ENSGT00530000063448_2_Domain_4 (1110, 1164)

LLSCQADVNLQDHDGSSALMLACHQGNADLV
RLLLAHPDCNSSLTDKAGRTALSIVLNSP---AHVEIAELLQAHSEQGRSLGL------

----------------------------------------------LPA-KDQSSQGD-E
EKGPPKSLPYSVETPYGFHLDLDFLKYVDDIEKGNTIKRIPIHRRAKQAKFSTLPRNFSL
PDSGARLQTALS-HQTWSPAVS--------RKVSLGTEERAQSLPP-GEHPQA--SAGGS
EGSYRRKALLAEAARQLEAA-APRDPELTSGSGRPQLLRASSMPATLLQNRAS-EDPRLT
SGPPAPPALPPLAAE-------GAFGPAEGFAG-VHNSTPGAATQPQGREFGDL----VP
GV----PELVRERAEPPRA--------A--EEAPQHLSLPRPRFSPPNALVVSEDAKDEL
HPRGAEV---VFSPGCPTPSPPPLPSPIPETELPLEEIELNISEIPPP-PPVEVDVRSIG
--IRVTEESLG---------LAPADPGSISSLRQQLLALEGELSGKTEELAQVRAALQQQ
EEEIKAKRQRIQELECTVAQLAEKLSHENTEDTQ----------GRADATVNTEPLQ-GL
LTRESCDKSIGVNLLSSTESESGGAPGEEND-LCGQDSHTQRDQSPAEFVPPS-QLSLPQ
DPEMV--LTSSLHSCLSTELRI--EEASSEQE-GD--PQVGDRDLVGGAGDSSCSSD---
-------IKAPSAGRE--ASSELPGKEGPGRPPSSPT-DATIGQYVK--KIQEL-LQEQW
-SCL-EHGYPELASAIKQPASKLSSIQRQLLSSLNLLLSAYSAQAPAQ--KESPAP-SS-
----SPPPMELSPSTSLKSIMKKKDYGFRAGGN--GTKKNLQFVGVNGG-----------
YETTSSE-ETSGEDSSP----EDLSDSEAEKKCDGPEHRW--GKDDHPGCKAGQGISEGT
-----CNTGQGKGLGE-----ELPLPKAERYKPSEEFLNACRAL-SQYLPDTG---TTTD
QLLRQNLNTISQEWFRISSRKSSSPAVVA-AYL---QPHSPHFLKLLVNLADG

PF00023 // ENSGT00530000063448_2_Domain_1 (1014, 1047)

NGNTALH
YSVSHSNFSIVKLLLETGVCNVDHQNK--AGYTAVMITPLASAETDEDMAVVWKLLREGN
V--NIQATQ

PF00023 // ENSGT00530000063448_2_Domain_3 (1090, 1122)

GGQTALMLGVSHDREDMVQALLSCQADVNLQD

ENSGT00530000063448_2_Linker_3_4 (1122, 1123)

H

PF00023 // ENSGT00530000063448_2_Domain_4 (1123, 1155)

DGSSALMLACHCGNADMV
RLLLAHPACDSSLTDKAGRTALSIALKPP---AHVEIAELLQAHAEQGRSLRP------

-------------------------------------------MEKTDA-KDQSCQGD-E
EKDPPKRH

PF12075 // ENSGT00530000063448_2_Domain_0 (69, 107)

PYSVETPYGFHLDLDFLKYVDDIEKGNTIKRIPIHRRS

ENSGT00530000063448_2_Linker_0_1 (107, 1014)

KQAKFSTLPRNFSL
PDSGARPPAAPS-PQNWSPVVP--------RKASLGTQEQTQSLPL-GNASQA--STSAS
EVSYHRRALLAEATRQLEAA-EPEDAEVTLGSGRPQLLRASSMPATLLHSRAS-EEPGLS
LEPPAPPALPPLQGEGSVCD--GTFGPAEGLAA-FHSSSPQAS----------------A
RI----PELVQEGAEPPEG--------T--VKAPNHLPLPGPPSSFQNVLVVLEDKEDEH
KARRAEV---VFSPGSPTPSPPPLPSPIPENELLLEEIELNISEIPPP-PPVEVDVRSIG
--IRVTEESLG---------LARVDPGSISSLKQQVSALEGELSGRTEELVQVRAALQQQ
EEEIKAREQRIRELEFTVAQLEGQLHQENTKDTQ----------GQTDAMVNTDPVH-GL
LTRESCDKGIEVNLLGSMESESWGHRGEENGLLWGPDGHKQGDQSPAEHV--P-QLSLPQ
GPEQV--LTPSVHSFLSTELRI--EEAGTEQE-GG--PQG----GTREAGGFPWGSD---
-------RKTPPAGREE-ANSDLPGKERPGRPPSSPT-DATIGQYVK--KIQEL-LQEQW
-NCL-EHGYPELASAIKQPASKLSSIQSQLLSSLNLLLSAYSAQAPPP--KEP--PASS-
----SSPPMEISPSTSLKSIMKKKDYGFRAGGN--GTKKNLQFVGVNGG-----------
YETTSSE-ETSGEDSSP----EDLSDSEAEKKCDGPDHRH--VKDAHLTCEAGQGIPEGT
-----CHAAQESGAGE-----EVPQSKAERYKPSEEFLNACQAL-SQHLPETG---TTTD
QLLRQSLNTISQEWFRVSSRKSSSPAVVA-SYLCEVQPHSPHFLKLLVNLADR

PF00023 // ENSGT00530000063448_2_Domain_1 (1014, 1047)

NGNTALH
YSVSHSNFSIAKLLLETGVCNVDHQNK--AGYTAVMITPLASAETDEDMAVVWKLLREGN
V--NIQATQGGQTALMLGVSHDREDMVQA

PF13857 // ENSGT00530000063448_2_Domain_4 (1110, 1165)

LLSCQADVNLQDHDGSSALMLACHHGNVDLV
RLLLAHPACDSSLTDKAGRTALSIALKSP---THMEIAGLLRAHAEQGRSLGL------

--------------------------------------------------QDQPAQGD-E
EKDSPKSH

PF12075 // ENSGT00530000063448_2_Domain_0 (69, 107)

PYSVETPYGFHLDLDFLKYVDDIEKGNTIRRVPIRRRT

ENSGT00530000063448_2_Linker_0_1 (107, 1007)

KQAKFSTLPRNFSL
PDSSVCPQTALL-QQRWSPTV--------PRKVFLGPQVQTQAPAPWGSTPQA--WAGGS
ELSNPRKALLVEADGQW------KDAALGLGSARPQLLRASSMPGTLLPSRAL-------
EGLPAPPAPPPLQDTGGSWD--GSFKPAEDPGL-------GAS-----------------
-A----VETAEELGDLVLGVPEEAERPAGEVQAPDRLSPPGPPPSFQSAPFIPEDVGVEV
QTWGPQV---GSTLGSSTPSPPPLPSPVPESELTLAGMELSISELPLP-PPPEVAVRSVG
--VRVTEEALGPDGS----------------LGQQLSALQRELASRTEELAAVRAAL---
----EAREQRVRELQGTVAQLEEKLTQDAQARA--------------HASV---------
-----------------------------------------HTGAPPGEQCPA-QLALPR
GPGTS--PASPMYSCPAMELRI--EEPAGSGQEGD--AGLAAEGTSG--------SD---
-------GEVALAAGEE-AGPEQ----PGGLPG-SPA-DAALGQYVR--KIQEL-LQEQW
-SCL-EHGYPELASALRQPASRLSSIRGQLLSSLSLLLSAYAAQGPQQEPAGHPGPSPPA
PGESPAPCAHVSPPPSLKSIMKKKDCGFGAGGN--GSKKNLQFVGVNGG-----------
YETTSSE-ETSAEDSSP----EGLSDSEAGENGGDP--ECVRHGDAHPEQ----GHPEAT
-----RSTGRGSAPAEGA-----SHPEAERCKPSEEFLHACRAL-SQHPPEAEA----AD
PLLRQSLNTVSQEWFRVSSRKSSSPAVVA-AYLLGVQPLSPHLLKL

PF13637 // ENSGT00530000063448_2_Domain_1 (1007, 1035)

LVNLADRNGNTALH
YSVSHSNFPIAKLLLDTGVCAVDRQNE--AGYTAVMITPLASAETDEDMAVVWRLLREGN
V--NIQATQ---------------------------------------------------
-----------------------------------------------------------

--------------------------------------------------KDQSSQGD-E
EKDPPKSHPYSVETPYGFHLDLDFLKYVDDIEKGNTIKRIPIHRRAKQAKFSTLPRNFSL
PDSGARPHAALS-HPNWPPVVP--------SKVSLGTEARAQPLPL-GDHPQA--A-GGS
EASYHRKALLTETARQLEA-------EVASGSGRPQLLRASSMPATLLQNRAS-EDPSLN
SGPPTPPALPPLQGEGGVCD--GAFGPAEGFAG-FSNSAQGAA----------------A
RI----PELILKGPEPPEG--------E--EAAANHLPFSSPPFS---SLVVLEDAEDQQ
ESRQAEV--AVTTPGSPTPSPPPLPSPVPENELPLEEIELNIIEIPPP-PPVEVDVRSIG
--IRVTEESLG---------LTSVDPGSISSLKQQLSGLEGELSGRTEELAQVRAALQRQ
EEEIKARGQRIRELECTLAQLTGKLSHENTKDAQ----------GQTDAMTNTDPLH-GL
LTRESCDKSIGVNLMGSTRSESWGAWGKGNGVLWRQESHKWGDRSPAEFVSPS-QLSLPQ
GSKMV--LTPSLHSCLSTELRI--EEGRSDQE-GG--HQVGAEGPVRGARGSPRSSE---
-------RKAPPAGRKE-AGSELPGKERPGRPPSSPTTDATIGQYVK--KIQEL-LQEQW
-SCL-EHGYPELAHAIKQPASKLSSIQSQLQSSLNLLLSAYSAHAAPQ--REP--PGPS-
----SSPPTEISPSTSLKSIMKKKDYGFRAGGN--GTKKNLQFVGVNGG-----------
YETTSSE-ETSSEDTSP----EDLSDSEAEKKCDGPESRR--GKDAHLSYKAGQGIPEGT
-----RDTDQQSGPGE-----ELPHPKAERYKPSEEFLNACRAL-SQHLPETG---TTTD
QLLKQSLNTISQEWFRVSSRKSSSPAVVA-TYLRGVQPHSPHLLKLLVNLADG

PF00023 // ENSGT00530000063448_2_Domain_1 (1014, 1047)

NGNTALH
YSVSHSSFSIVRLLLETGVCNVDHQNK--AGYTAVMITPLASAETDEDMAVVWKLLREGD
V--NIQATQ

PF00023 // ENSGT00530000063448_2_Domain_3 (1090, 1122)

GGQTALMLGVSHDREDMVQALLSCQADVNLQD

ENSGT00530000063448_2_Linker_3_4 (1122, 1123)

H

PF00023 // ENSGT00530000063448_2_Domain_4 (1123, 1155)

DGSSALMLACRHGNVDMV
RLLLAHPACDSSLTDKAGRTALSIVLKSP---AHVEIAGLLRAHAKQGRSLGP------

-------------------------------------------MEKTDA-KDPPSQVD-E
EKDPPKSHPYSVETPYGFHLDLDFLKYVDDIEKGNTLKRIPIHRRAKQAKFSTLPRNFSL
PDGGARPQAAFP-HSDWSPVVL--------RKVSLGMEEQAQTLPL-GDFQA---LASGG
DMSYHRKALLAEATRQLGTA-PPEEAELLSVSGRPQLLRASSMPATLLQNRAS-EEPSLP
SALPPPPTLPSLQGEGSVCD--GTFGSVEGFAD-FHSCSPQAS----------------T
RI----PELVQEGANPVEG--------K--EEAPSHLFFPAPPSSSQHAL-----GEDKH
ETREAEV---VITSGSPTPSPPPLPSPIPENDFLLEEIELNISEIPPP-PPVEVDVRSIG
--IRVTEETLG---------LATVDPSSISCLQQQVTALEGELSGRSEELAQARAALQQQ
EEEIRAREQRXXXXXXXXXXXXXXXXXXXXXDTQ----------DQTDAMVNTDPLR-GL
LIREACDKGIGVNLLGMRGSESWEARGEANGLLLGQGSYTQADQSPAECVLSP-RPSLLQ
GPEVV--LTSSLRSCLSTELRI--EEAGFEQE-GG--LQVGVEGLASEAGGSSWSSS---
-------RKPPPVGRAK-VDPELPRKERPERPPNSPT-DVTIGQYVK--KIQEL-LQEQW
-NCL-EHGYPELASAIKQPASKLSSIQSQLLSSLNLLLSAYSAQAPPP--EP---PTPA-
----FSPPMEISPSTSLKSIMKKKDYGFRAGGN--GTKKNLQFVGVNGG-----------
YETTSSE-ETSGEDSSP----EDLSDSEAEKKCDGPEHRR--GKDTHPGYEAVQGNPEGT
-----HSTGHEGRPGE-----EIPHPRADRYKHSEEFLNACQAL-GQHLPETG---SSND
RFLRQSLNIISQEWFRVSSRKSSSPALVA-AYLRGVQPYSPHLLKLLVNLADG

PF00023 // ENSGT00530000063448_2_Domain_1 (1014, 1047)

NGNTALH
YSVSHSNFSIVKLLLETGVCDVDRQNK--AGYTAVMITPLASAETDEDMAVVWKLLRQGN
V--NIQATQ

PF00023 // ENSGT00530000063448_2_Domain_3 (1090, 1122)

GGQTALMLGVSHDRGDMVRALLSCQADVNLQD

ENSGT00530000063448_2_Linker_3_4 (1122, 1123)

H

PF00023 // ENSGT00530000063448_2_Domain_4 (1123, 1155)

EGSSALMLACRHGNVDMV
RLLLAHPTCDSSLTDKAGQTALSIIQKSP---AHVEIAGLLQAHAEQARSLGP------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----MEKTDEISPSTSLKSIMKKKDYGFRAGGN--GTKKNLQFVGVNGG-----------
YETTSSE-ETSGEDSSP----EDLSDSEAEKKCDGPDHRH--VKDAHLTCEVGQGIPEGS
-----CHAAQESGAGE-----EVPQSKAERYKPSEEFLNACQAL-SQHLPETG---TTTD
QLLRQSLNTISQEWFRVSSRKSSSPAVVA-SYLCEVQPHSPHFLKLL

PF13637 // ENSGT00530000063448_2_Domain_1 (1008, 1035)

VNLADRNGNTALH
YSVSHSNFSIAKLLLETGVCNVDHQNK--AGYTAVMITPLASAETNEDMAVVWKLLREGN
V--NIQATQGGQTALMLGVSHDREDMVQA

PF13857 // ENSGT00530000063448_2_Domain_4 (1110, 1165)

LLSCQADVNLQDHDGSSALMLACHHGNVDLV
RLLLAHPACDSSLTDKAGRTALSIALKSP---THMEIAGLLRAHAEQGRSLGL------

-------------------------------------------LLCLSA-KDQPSQVD-E
EKDPPKSHPYSVETPYGFHLDLDFLKYVDDIEKGNTIKRIPIHRRAKQSKFSTLPRNFSL
PDSGARAHAALP-HSHWSPVVP--------RKVSHELEERAQTRPL-GDSSQA--LASGS
EVSYHRKALLAEATRQLGAT-PPEDAELFPGGGRPQLLRASSMPATLLQNRAS-EEPSLP
SALPPPPVLPPLQGEGS--D--VTFGPAEGFAG-FHSSSPQASTQPKDREFGDL----VP
GI----PELVQEGTKPLGG--------K--EEAPNHLSFLASPSSSQS--ALVEDAEDKR
ETREAEV---VSTPGSPTPSPPPLPSPIPENDLPLEEIELNISEIPPP-PPVEVDVRSIG
--IRVTEESLG---------FARVDPSSISSLKQQVTALEGELSGRSEELAQARATLQQQ
EEEIKAREQRIQELECTVAQLEEKLSQYNSKDTQ----------GQTDAMVNTDPLH-GL
STREAYDKSIGVNLLGMTESESWEARGEENGLLLGQGSHKQGDQSPAECMLSP-PLSLPQ
GPEMV--LTSSLHSCLSTELRI--EEVGSEQE-EG--PQVGTEGLASEAGGPPWSSS---
-------RKTPPAGREK-AGPELPGKERPERPPSSPT-DATIGQYVK--KIQEL-LQEQW
-NCL-EHGYPELASAIKQPASKLSSIQSQLLSSLNLLLSAYSAQAPPP--EP-PAPSSFS
PPMVVPTPQEISPPTSLKSIMKKKDYGFRAGGN--GTKKNLQFVGVNGG-----------
YETTSSE-ETSGEDSSP----EDLSDSEAEKKCDGLEHRR--GKDTHPSYETRQGVPEGT
-----HNAGQEGRPGE-----EIPHPKAERYKPSEEFLNACQAL-SQHLPEIG---TTTD
RLLRQSLNTISQEWFRISSRKSSSPAVVA-AYLRGVQPYSPHFLKLLVNLADG

PF00023 // ENSGT00530000063448_2_Domain_1 (1014, 1047)

NGNTALH
YSVSHSNFSIVKLLLETGVCSVDHQNK--AGYTAVMITPLASAETDEDMAVVWKLLREGN
V--NIQATQ

PF00023 // ENSGT00530000063448_2_Domain_3 (1090, 1122)

GGQTALMLGVSHDREDMVQALLSCQADVNLQD

ENSGT00530000063448_2_Linker_3_4 (1122, 1123)

H

PF00023 // ENSGT00530000063448_2_Domain_4 (1123, 1155)

DGSSALMLACRHGNADMV
RLLLAHPACDSSLTDKAGHTALSIVLKSP---AHVEIAGLLRAHAEQGRSPGP------

-------------------------------------------MEKTKA-QDPASQGD-E
EKGPPRSHQ

PF12075 // ENSGT00530000063448_2_Domain_0 (70, 107)

YSVETPYGFRLDLDFLKYVDDIEKGHTIRRVPIHRRA

ENSGT00530000063448_2_Linker_0_1 (107, 1014)

KQTKFSTLPRNFSL
PSSGEQAPAAPL-PQRWSPAV--------PRKESLGPQDQSQPPAPQGSAAQA--WARGS
ELSHPRKAQLAEAAGQG------DDTMPGCASARPQLLRASSMPATLPPARGS-EA----
--SPAPPAPPPLQDTGSAWD--NAFRPAEGSAD-LPSPRPGASAG---------------
-E----T--VKEPGDWVLGAPK-----EAEPPAGEEQAPDRPSLSFQNAHVVPEDGRGEG
---QALA---VSTPGSSTPSPPPLPSPVPESELALAEIELSISELPPPPPPLEMAVRSVG
--VRVTEEALGLGDG----------------LGQQLRALQDELASRAEQLVRVQAAL---
----EAKEQRIRELEGAVAQLEEKLGADAQ--GS---------QGRVDSAVSTEHLC-GL
HRVDTCDKGVEVALLSPMDSGSWRA-LGEEGGPL-----WVTDSAPPTDQRPA-QLPLPQ
GPGTA--PASPVRGCLSVELRI--EEPGPAQ-E-E--GLA-AEGTTD--------SD---
-------GETAPAAREE-AGSQHQ----GALPGSP-P-DAALGQ-YVRK-IQELL-QEQW
-SCLE-HGYPELASALRQPASRLSNIRGQLLSSLSLLLSACAAQGPPQEAAGHPAPSPSA
PAP---PASELSPSTSLKSIMKKKDCGFRAGGN--GTKKNLQFVGVNGG-----------
YETTSSE-ETSGEDSSP----EDLSDSEAEKKCSDL--ECVQDGDAPSQ-----GHPEDT
-----CSTARESGTEEGA-P----HSKAERCKPSEEFLSAC-RALSRHPPDA-T-AA--D
PLLERSLSTFSQEWFRVSSRKSSSPAVVA-AYLLEVQPLSPKLLELLVNLADR

PF00023 // ENSGT00530000063448_2_Domain_1 (1014, 1043)

NGNTALH
YSLSHANFPVAKLLLDTGVCAVDRQNK--AGYTAVMITPLASAETAEDMAVVRQLLREGD
V--NIQATQGGQTALMLGVSHDRG

PF12796 // ENSGT00530000063448_2_Domain_4 (1105, 1182)

DMVRALLCCQADVNLQDHEGATALMLACRHGNADLV
RLLLAQPSCDSSLADKAGRTALSIALQSP---AHTEIAGLLQAHAEQAGRPGPEGPQQN

-------------------------------------------MEKTDA-KDQSSQGE-E
EKDPPKSH

PF12075 // ENSGT00530000063448_2_Domain_0 (69, 107)

PYSVETPYGFHLDLDFLKYVDDIEKGNTIKRIPIHRRA

ENSGT00530000063448_2_Linker_0_1 (107, 1008)

KQAKFSTLPRNFSL
PDSRARPHAALP-HQNWSPVVP--------RKVPLGTEERAQSLPP-GEHVQA--STSGS
DVSYHRKALLAETARHLEAA-APREAELASGSGRPQLLRASSMPATLLQNRAS-EDPSLN
SGPPTPPALPPLQGEGNVCD--GTFGPADGFAG-FQNSTPRATTQPKVREFGDL----VP
GI----PELVQEGAEPPED--------ADDEEAPNHLSFPSPPFSSQDALIVLEDEEDEH
KTPEAEV---VVTPGSPTPSPPPLPSPIPENEFPLEEIELNISEIPPP-PPVEIDVRSIG
--IRVTEESLG---------LPTMDPVSISSLKQQLSALEGELSGRTEELAQVRAALQQQ
EEEIKARGQRIQELECTVAQLADKLSHENAKDAQ----------GQTDAVVNTDPLH-GL
LTRELCDKSIEVNLLGSTGSESWRAGGEENGLLWGQDSHKPGDRSPAEFMPPS-QLSLPQ
GPEMV--LTPSLHSCLSTELRI--EETGSELE-GD--PQVGAKGLGKGPGGSPWSSD---
-------RKTPPAGREE-ASSELPGKERPGRPPSSPT-DATIGQYVK--KIQEL-LQEQW
-SCL-EHGYPELASAIKQPASKLSSIQSQLLSSLNLLLSAYSAHAPPQ--KEPPAPAS--
-----SPPMEISPSTSLKSIMKKKDYGFRAGGN--GTKKNLQFVGVNGG-----------
YETTSSE-ETSGEDSSP----EDLSDSEAEKKCDGTEHKQ--GKEAHPGCKAGQGIPEGT
-----STSGQDGGPPE-----DLPHPKAERYKPSEEFLSACRAL-SQHMPESG---ATTD
QLLRQSLNTISQEWFRVSSRKSSSPAVVA-AYLRGVQPHSPHFLKLL

PF13637 // ENSGT00530000063448_2_Domain_1 (1008, 1035)

VNMADGNGNTALH
YSVSHSNFSVVKLLLETGVCNVDHQNK--AGYTAVMITPLASAETDEDMAVVWKLLREGN
V--NIQATQGGQTALMLGVSHDREDMVQA

PF13857 // ENSGT00530000063448_2_Domain_4 (1110, 1164)

LLNCQADVNLQDHEGSSALMLACHHGNADMV
RLLLAHPACDSSLTDKAGRTALSIVLKSP---AHVEIAGLLRAHAEQGRSLGP------

-------------------------------------------MEKTDA-KDQSSQGD-E
EKEPPKSH

PF12075 // ENSGT00530000063448_2_Domain_0 (69, 107)

PYSVETPYGFHLDLDFLKYVDDIEKGNTIKRIPIHRRA

ENSGT00530000063448_2_Linker_0_1 (107, 1000)

KQAKFSTLPRNFSL
PDSGARPSAAPP-PHNWSPVVP--------MKASCGTQEQTQSLPL-GNAPQA--SPSTS
EVSYHRRALLAEATRQLEAA-EPEDADLTPGSGRPQLLRASSMPATLLHSRAS-EEPGLS
LGVPAPPPLPPLQGEGSVCN--GTFGPTEGLAG-FQSSSPQAP----------------T
RI----PELVQKGA---EG--------M--VKAPNHLPLPGPSSSFQNALVVLEDEEDEH
KSRDAER---VFTPGSPTPSPPPLPSPIPENELLLEEIELNISEIPPP-PPVEVDVRSIG
--IRVTEESLG---------LARVDPGSVSILKQQVSALEGELSGRTEELAQVRAALQQQ
EEEIRAREQRIRELECTIAQLEGQLPQENVKDAP----------GQADAMVNTDPVH-GL
LTRESCDKSIEVNLLGSMESESWGHRGEENGLLWGPGGHKQGDQSPAGHGLPP-PLSLPQ
GPEQV--LTPSVHSFLSTELRI--EEADSEQE-GG--PQG----EAGGAGGSPWGSD---
-------RKTPPAGREE-ASSELPGKEHSGRPPSSPT-DATIGQYVK--KIQEL-LQEQW
-NCL-EHGYPELASAIKQPASKLSSIQSQLLSSLNLLLSAYLAQAPPP--KEP--PASA-
----SSPPMEISPSTSIKSIMKKKDYGFRAGGN--GTKKNLQFVGVNGG-----------
YETTSSE-ETSGEDSSP----EELSDSEAEKKCDGPDHRD--VKDAHLTCEAGQGIPEGS
-----RYATQESGPGE-----EVSHSKAERYKPSEEFLTACRAL-SQRLPETG---TTTD
QLLRQSLNTISQEWFRVSSRKSSSPAVVA-AYLCEVQPH

PF12796 // ENSGT00530000063448_2_Domain_1 (1000, 1057)

SPHFLQLLVNLADRNGNTALH
YSVSHSNFSIVKLLLETGVCNVDHQNK--AGYTAVM

ENSGT00530000063448_2_Linker_1_4 (1057, 1110)

ITPLASAETSEDMAVVWKLLREGN
V--NIQATQGGQTALMLGVSHDREDMVQA

PF13857 // ENSGT00530000063448_2_Domain_4 (1110, 1165)

LLSCQADVNLQDHDGSSALMLACHHGNVDLV
RLLLAHPACDSSLTDKAGRTALSIALKSP---THMEIAGLLRAHAEQGRSLGL------

-------------------------------------------MEKTNA-KDQSSQGD-E
EKDPPKSH

PF12075 // ENSGT00530000063448_2_Domain_0 (69, 107)

PYSVETPYGFHLDLDFLKYVDDIEKGNTIKRIPIHRRA

ENSGT00530000063448_2_Linker_0_1 (107, 1002)

KQAKFSTLPRNFSL
PNSGARPQAALL-HHNWSPGVL--------RKVSLGAQEQTQPPLP-GAAPQA--AAGGS
ELSYHRRAVLAEASRQLEAA-APEDTELGPGSGRPQLLRASSMPATLQQSRAP-EEPRLS
SGAPAPPSFPPLQGEGSVCD--GAFGPAEGFAG-SHLGEPVP------------------
GT----LELVREGAEPPAG--------G--ATAASPLGLPGPPSSFPGALVGPQDA----
--GAAEV---AVSPGSPTPSPPPLPSPIPESELPLEEIELSISEIPPP-PPVEVDVRSVG
--VRVTEESLG---------LA----GGVSGLEWQVSALQGELSGRTEELAQVRAALQQQ
EEEVKAREQRIQELERAVAQLEEKLSQETAREAQ----------GQTDAMVNTDPLH-GL
LTRESCDKSTEVNLPGVTESESWGAHGAENGLLWGQDSPKQGDQSPTEHVLPP-QLSLLQ
GPEKV--LSSSLGSCLSTELRI--EEADSEQE-GD--PQGGAEGLARGAGGFPWSSD---
-------RKTPPAGRQE-PSSELPGKEHPGRPPSSPT-DATLGQYVK--KIQEL-LQEQW
-SCL-EHGYPELASAIRQPASKLSSIQSQLLSSLNLLLSAYSAQAPQH--KEP--PAP--
----SSPPKEISPSTSLKSIMKKKDYGFRAGGN--GTKKNLQFVGVNGG-----------
YETTSSE-ETSGEDSSP----EDLSDSEAEKKCDGPEHRC--TKDAHPSCEAGQGVPEGT
-----RHPGQESGPGE-----EVPHSKAERYKPSEEFLTACRAL-SQQLPETG---TSTD
QLLRQSLNTVSQEWFRVSSRKSSSPAMVA-AYLHGVQPHSP

PF13637 // ENSGT00530000063448_2_Domain_1 (1002, 1035)

HFLKLLVNLADRNGNTALH
YSVSHSNFSIAKLLLETGVCNVDHQNK--AGYTAVMITPLASPETDEDMAVVWKLLREGN
V--NIQATQGGQTALMLGVAHDREDMVQA

PF13857 // ENSGT00530000063448_2_Domain_4 (1110, 1164)

LLSCQADVNLQDHDGSSALMLACHHGNADMV
RLLLAHPACDSSLTDKAGRTALSIVLKSP---THMEIAGLLRAHAEQGRSLGP------

--------------------------------------------------KEQPSQAD-E
EKGPPRSHPYSVETPYGFHLDLDFLKYVDDIEKGNTIKRIPIHRRAKQAKFSTLPRNFSL
PDSGARPHAALP-HPIWSPAM--------PRKVSFGVEEPAQPLPTDA-SSPA--PARGS
EMSYPRKILLAEAARPSEAA-PPEDAEPLCGSGRPQLLRASSMPATLPQSKAPCEEGGLP
SALPRPPALPPLHSEGSFCE--GTFGPAGGFAD-LHNSSPQGPAQ---------------
-I----PEGVWE-----GAKPQ-----EGKEEAADHLSFPGPSLS----QALVEDAEGEH
EIREAEA---VVTP-------------DXEHELPLEDIELNISEIPPP-PPVEVAVRSIG
--IRVTEESVGLARAAP--S-------TISSVKQQVTALEGELSGRSEELAQTRAALQQQ
KEDIKAREQLIRELECTITQLEAKLNQENAK-DT---------QGHIDAMVNTDPLH-GL
LMRESCDKSIGVSLLGLPESESWEA-REGGNGILGQGSLNQRDQSPAECVLTP-QLSRPQ
GPEVD--FTASSQSCLSTELRI--EEADSEQ-EGG--PPGGARGLVGDAEGCAWSSS---
-------KQAPPAATEE-ASPGPPGKECPERPHSSPT-DVTIGQYVK--KIQEL-LREQW
-NCL-EHGYTELGIAIRQPASKLSSIQSQLLSSLNLLLSAYSAQAQLNLSA--------S
LFS---PPREISPSASLKSIMKKKDYGFRAGGN--GTKKNLHFVGVNGG-----------
YETTSSE-ETSGEDSSP----EDLSDSEAEKKSNGP--EHRRAKDTQPRCEARQGVPEHT
-----CGADQDCRPGEDA-P----LPKAERYKPSEEFLKACRAL-SQHLPEIGA-TT--D
RLLXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXLCDVDHQNQ--AGYTAVMITPLAAAETSEDMAVVWKLLREGN
V--NIQASQ

PF00023 // ENSGT00530000063448_2_Domain_3 (1090, 1122)

GGQTALMLGVSHDREDMVQALLSCQADINLQD

ENSGT00530000063448_2_Linker_3_4 (1122, 1123)

Q

PF00023 // ENSGT00530000063448_2_Domain_4 (1123, 1155)

EGSSALMLACHHSNADMV
RLLLAHPACNSSLTDKAGRTALSIVLEAP---AHVEIAGLLQAHAEQDRSLGP------

------------------------------------------------A-GDQPSKPA-E
DRDQPRSL

PF12075 // ENSGT00530000063448_2_Domain_0 (69, 107)

PYSVETPYGFHLDLDFLKYVDDIEKGNTIKRVHIHRKA

ENSGT00530000063448_2_Linker_0_1 (107, 1014)

KQPKFSTLPRNFSL
PANGSRVCASSP-HKSWTATCSFAQ-----RKASLPAEDTTCLITS-YD---SPSPSTAE
ELSYRKKALLAETVRQREIIHH--EEESGSCRGRPQLLRASSMPAKLLPSKSS-EEENEC
SHLAALSQAP---EAESSTE--ILFNPAKESLDSYYSDSLTQ----------------GK
AI----PELDRQPAGLPKE--------SMQIQS----PRQSQPSTAQELLLVTESGGEEC
YAPETNTCPELVQDDSISLN---APK-LMHENENHEEIELNIHEIMPS-VPEKADVSSIW
--TRAKEENLDREPL----LCDTVEPSRITSLKQQIAALEEQLHSKTEELSK--------
-----AKERSIKILASSKAQLEEKLCQENTKDTE-PSKQDGNALQYHDAAVNTEHMQ-AN
TFKEAYDKCINVNIPIATESVGCGTYGVDNVNLQVKEAASLGKQKGTGTNTEP-------
---------PVFIPCF-TELKI--DEQINKDCQNQRNSYDRQSCAASSPIGESCSRTGKA
DSNGNKPGGNKPVFAEG-VKQDLIEEENHTEQQD-SSANDPIGQYVK--KIQEL-LQEQW
-MCL-EHGYPELASAIKQPASKLSSIQNQIVNSLNLLLSAYTTHAPSD--KQS-------
PTSLFSSNIEISPTTSLKSIMKKKGYGFHAGGN--GTKKNLQFVGVNGG-----------
YETTSSE-DTSGEDGSS----EGNSDSEMERKYDTFEHRQVKAA--SENTHASTGVSQCT
----RHED-NEPQEVEEI-TMASTPHKTDRCKPSEDFLDGCLLL-SKHLSEIR---TTND
KYLRHILNTVCQEWFRVSSRKSSSPEVVA-AYLKEFKAIHPQLLKMIINLADG

PF00023 // ENSGT00530000063448_2_Domain_1 (1014, 1040)

NGNTALH
YSVSHSNFLIVKLLLETGVCDVDHQNK--AGYTAVMITPLASAENDEDMEVVLKLLKEGN
V--NIRASQG

PF00023 // ENSGT00530000063448_2_Domain_3 (1091, 1122)

GQTALMLGVSHDRGDMVRALLSCKADINLQDDNGTSALMVACHHDNAEIA
KLLLAHPGCNTALKDKSGSSALSIALKS----AHMEIAELLQAHTEQSRSLSK------

-------------------------------------------MEKADA-KDQSSQGE-E
EKDPPKSH

PF12075 // ENSGT00530000063448_2_Domain_0 (69, 107)

PYSVETPYGFHLDLDFLKYVDDIEKGHTIKRIPIHRRAKQAKFSTLPRNFSL
PDSGARTHAAPP-QRNWSPVVP--------RKISLGTQEQSPSLPL-GDVPQA--SGHGS
ELSYHRKGLLAEDTRQVEAG-ALED----GGSGRPQLLRASSMPATLLQNRAP-DESSLT
SGPSTLLPLPLLQSDSSVCD--RTFDSAEGFTG-FQA-----STQSTDRGVGEL----GP
AI----PELVWEGAEPEEG--------D--IKTSSHLSQSGPPSSVQNVPIVLEGVEIQH
QVRNAEV---VLTSGSSTPSPPPLPSPIPENELFLEEIELNISEIPPP-PPIEVDVRSIG
--IRVTEESLG---------LVGSDTGSISSLKNQVSTLEDKLSGRTEELTQVRAALAWQ
QEETKAREQRIQELECTVVQLEEKLSQEKVSGAP----------DRTDATVNTDPLL-EL
IPRESCDKNIGVNLLRTPDPECWASRAEKNGFPRVHNSHKQGHQSPEEPVLPP-QLSLSR
GPEQV--LASSLCSCLSMELRI--EEDVSEQE-RG--PQAGAEDLSRATGASSWSSP---
-------RESASVIREE-ASSELPGAERPGRPASSPQ-DATIGQYVK--KIQEL-LHEQW
-NCL-EHGYPELASAIKQPASKLSSIQNQLLSSLNLLLSAYSAQAPEP--KEPPAPPS--
--STPPPPPEISPSTSLKSIMKKKDYGFRAGGN--GTKKNLQFVGVNGG-----------
YETTSSE-DTSGEDSSP----EDVSDGETEKKRDCSEPRQ--GRGMHPACEAGQDVPEGI
----SSNSGQTSGSGE-----EVSHLKPERCKPSEEFLNACQAL-SQHLPETG---AITE
QLLAGRTALSI---------VLNSPARVEIAELLQAHSEQGRPLGL--ELQKH-------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

-------------------------------------------MEKTDA-KDQSSQGD-E
EKEPPKSH

PF12075 // ENSGT00530000063448_2_Domain_0 (69, 107)

PYSVETPYGFHLDLDFLKYVDDIEKGNTIKRIPIHRRA

ENSGT00530000063448_2_Linker_0_1 (107, 1009)

KQAKFSTLPRNFSL
PDSGARASVAPL-PHNWSPVVS--------RKPSCGTQEQTQSLPL-GNAPQA--STSAS
EVSYHRRALLAEATRQLEAA-EPEDTELIPGSGRPQLLRASSMPATLLHSRAS-EEPGLS
PGPPAPPPLPPLQSEGSVCD--GTFGPTEGLAG-FQSSSPQAP----------------T
RI----PELVQKGAEPPEG--------M--VKAPNHLPLPGPSSSFQNALVVLEDKEDEH
KAREAGG---VFTPGSPTPSPPPLPSPIPENELLLEEIELNISEIPPP-PPVEVDVRSIG
--IRVTEESLG---------LARVDPGSISILKQQVSALEGELSGRTKELAQVRAALQQQ
EEEIKAREQRIRELECTIDQLEGQLHQENAKDTQ----------DQVDAMVNTDPVH-GP
LTRESCDKSIEVNLLGSMESESWGHRGEENGLLWGPGSHKQGDQSPAGHMLPP-LLSLPQ
GPEQV--HTHSVHSFLSTELRI--EEADSEQE-GG--PQG----EVRGAGGSPWSSD---
-------RKTPPAGREE-ASSELPGKEHSGRPPSSPT-DATIGQYVK--KIQEL-LQEQW
-NCL-EHGYPELASAIKQPASKLSSIQSQLLSSLNLLLSAYSAQAPQP--KEP--PASS-
----SSPPMEISPSTSIKSIMKKKDYGFRAGGN--GTKKNLQFVGVNGG-----------
YETTSSE-ETSGEDSSP----EDLSDSEAEKKCDGPDHRH--VKDAHLTCEAGQGIPEVS
-----RYATQESGPGE-----EVPHSKAERCKPSEEFLNACRAL-SQHLPETG---TTTD
QLLRQSLNTISQEWFRVSSRKSSSPAVVA-AYLREVQPHSPHFLQLLV

PF13637 // ENSGT00530000063448_2_Domain_1 (1009, 1035)

NLADRNGNTALH
YSVSHSNFSIVKLLLETGVCNVDHPNK--AGYTAVMITPLASAETSEDMAVVWKLLREGN
V--NIQATQGGQTA

PF12796 // ENSGT00530000063448_2_Domain_4 (1095, 1183)

LMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMLACYHGNVDLV
RLLLAHPACDSSLTDKAGRTALSIALKSP---THMEIAGLLRAHAEQGRSLGL------

-------------------------------------------MEKMDA-KDQSPQGD-E
EKEPPKSY

PF12075 // ENSGT00530000063448_2_Domain_0 (69, 107)

PYSVETPYGFHLDLDFLKYVDDIEKGHTIKRIPIHRRA

ENSGT00530000063448_2_Linker_0_1 (107, 1015)

KQAKFSTLPRNFSL
PNSGDRSHAAPP-QQNWSPVVP--------RKISLGTQEQSQSVPL-GDLPQA--TVHGN
ELSYHRKALLAKDTRQVEAG-SLED----AGSGRPQLLRASSMPATLPQNQAP-EVPNLT
SGPSALLVLPPLQDEGSVRD--GTFDPAEGLMG-FQA-----AAQSTDRAVEEL----EP
AI----PEPVWEGAEPEEG--------D--IKAASHLSQPAPSSSVQNVSVDLEEVDIQH
HTRTADL---ALSPGSSTPSPPPLPSPIPENELSLEEIELNISEIPPP-PPIEVDVRSVG
--VRVTEESLG---------LVETATSSISSLKSQVLDLEDKLSGRTEELAQVRAALEQQ
EEETKAREQRIQELECTVAHLEEKLSQEKASDAL----------DRTDAMVNTDPLR-EL
IPRESQDKNIGVNLLSTPVPECWASRAEKNGFPWVQTNHKQSYPSPEEPALPP-QLSLPR
GPEQI--LASSLCSCLSMELRI--EEEVSEQE-RD--PDGGAGSLSREAGGSPWSR----
-------RESAPVIREE-ASSQLPGAERPGRPASSPQ-DATIGQYVK--KIQEL-LHEQW
-NCL-EHGYPELASAIKQPASKLSSIQNQLLSSLNLLLSAYSAQAPEP--KESPVPPSST
----PPPPPEISPSTSLKSIMKKKDYGFRAGGN--GTKKNLQFVGVNGG-----------
YETTSSE-DTSGEDSSP----EDLSDSETEKKQDCSEPRE--DRDMHLSCEAGQGVSKGT
-----GNSGHMSEPRK-----GVSHMKAERYKPSEEFLNACQAL-SQHLPEAG---ATNK
QLLRQSLNTISQEWFRVSSRKLSSPEAVA-ACLLEVQPQSPHLLKLLVNLADRS

PF00023 // ENSGT00530000063448_2_Domain_1 (1015, 1047)

GNTALH
YSVSHSNFAIAKLLLDTGVCNVDHQNK--AGYTAVMITPLASPKTKEDMAVVWKLLREGN
V--NIQATQGGQTALMLGVSHDREDMVQA

PF13857 // ENSGT00530000063448_2_Domain_4 (1110, 1164)

LLSCKADVNLQDHDGSSALMLACHQGNADLV
RLLLAHADCNSNLTDKAGQTALSIVLNSP---AHVEIAELLRAHSEQGRSLGLKELQKN

-------------------------------------------FTCLPA-KDQSSQGD-E
EKGPPKSHPYSVETPYGFHLDLDFLKYVDDIEKGNTIRRIPIHRRAKQAKFSTLPRNFSL
PDSRARPHAALP-HQNWSPVVP--------RKVSLGTEEQAQSLPP-GEHPQA--SASGS
EVSYHRKALLAETARHLEAA-APREAELAPGSGRPQLLRASSMPATLLQNRAS-EDSSLN
SGPPTPPAFPPLQGEGNACD--GTFGPADGFAG-FQNSTPRATTQLKVREFGDL----VP
GI----PELVQEGTEPPED--------EDEEEALNHLSFPSPPFSSQDALVVLEDEEDEH
KTREAEV---VVTPGSPTPSPPPLPSPIPENEFPLEEIELNISEIPPP-PPVEIDVRSIG
--IRVTEESLG---------LPAMDLGSISSLKKRLSALEGELSGRTEELAQVRAALQQQ
EEEIKARGQRIQELEHTVAQLAEKLSHENTRDTQ----------GQTDAMVNTDPLH-AL
LTRESCDKSTEVNLLGSTGSESWRAGGEENGLLGGQVSHKPGDRSPAELM--P-QLSLPQ
GPEMV--LTPSLPSCLSTELRI--EEAGSEQE-GS--PQVGAEGLGKGEGGSSWSSD---
-------RKMPPAGREA-ASSELPGKERSRRPPSSPT-DATLGQYVK--KIQEL-LQEQW
-SCL-EHGYPELASAIKQPASKLSSIQSQLLSSLNLLLSAYSAHAPPQ--QEPPVPST--
-----SPPMEISPSTSLKSIMKKKDYGFRAGGN--GTKKNLQFVGVNGG-----------
YETTSSE-ETSGEDSSP----EDLSDSEAEKKCDGPEQRR--GKEAHPACKAGQGIPEGT
-----STTGQESEPGE-----ELPHPKAERYKPSEEFLNACWAL-SQHLPETG---ATTD
QLLRQTLNTIRQEWFRVSSRKSSSPAVVA-AYLRGVQ--SPHFLKLLVNLADG

PF00023 // ENSGT00530000063448_2_Domain_1 (1014, 1047)

NGNTALH
YSVSHSNFPVVKLLLETGVCNVDHQNR--AGYTAVMITPLASAETEEDMAVVWKLLREGN
V--NIQATQ

PF00023 // ENSGT00530000063448_2_Domain_3 (1090, 1122)

GGQTALMLGVSHDREDMVQALLSCQADVNLQD

ENSGT00530000063448_2_Linker_3_4 (1122, 1123)

H

PF00023 // ENSGT00530000063448_2_Domain_4 (1123, 1155)

EGSSALMLACHHGNANMV
RLLLAHPTCDSMLTDKAGRTALSIVLKSP---THVEIAGLLRAHAEQGRSLGP------

-------------------------------------------MEKTDA-KDQSSQGD-E
EKEPPKSH

PF12075 // ENSGT00530000063448_2_Domain_0 (69, 107)

PYSVETPYGFHLDLDFLKYVDDIEKGNTIKRIPIHRRA

ENSGT00530000063448_2_Linker_0_1 (107, 1005)

KQAKFSTLPRNFSL
PDSGARPHAVLS-HPNWSPMVS--------RKV-LGTEARAQPLPL-GDHPQAPQAASGS
ELSYHRKALLMETARQLEAAAAPGEAELTSGSGRPQLLRASSMPATLLQTRAS-EDPSLN
SGPPTPPVLPQLQGEGIVCD--GAFGPAEGFAG-FSNSTPRAATQPEVRESGDL----VP
GI----AELIQEGPEPPKS--------E--EEAPNHLSFPSPPFSSQNALVVLEEAEDQQ
ESRGAQV--VVTSPSSPTPSPPPLPSPIPENELPLEEIELNISEIPPP-PPVEVDVRSIG
--IRVTEESLG---------LASRDPGSISSLKQQISDLEGELSGRTEELAQVRAALQRQ
EEEIKARGQRIQELECTVAQLVEKLSGGNTKDAQ----------GQTDAMVGTDPLQ-GL
LTRQSCDKSIGVSLLGSVGSESWGARGEGNGPLWGRESHTRGDGSPAGLVSPP-QPSLPQ
GSETV--LMPSSHSCLSTELRI--EEGGSEQA-GG--SSVGIKGLDRGVGGSPGSAE---
-------RKAPPAGREE-AGPELSGKERPGRPPGSPT-DATIGQYVK--KIQEL-LQEQW
-SCL-EHGYPELARAIKQPASKLSSIQSQLQSSLNLLLSAYSAQAPPQ--KEP--PGPS-
----SSPPMEISPSTSLKSIMKKKDYGFRAGGN--GTKKNLQFVGVNGG-----------
YETTSSE-ETSGEDSSP----EDLSDSEAEKKCDGPEPRQ--GKDAHLSCRVSQGTHEGT
-----HDTDQETGPGE-----ELPHPKTERYKPSEEFLNACRAL-SQHLPQTG---TTTD
QLLKQSLNTISQEWFRISSRKSSSPAVVA-AYLRGVQPHSPHLL

PF13637 // ENSGT00530000063448_2_Domain_1 (1005, 1035)

KLLVNLADGNGNTALH
YSVSHSNFSIVKLLLETGVCNVDHQNK--AGYTAVMITPLASAETNEDMAVVWKLLREGN
V--NIQATQGGQTALMLGVSHDRGD

PF12796 // ENSGT00530000063448_2_Domain_4 (1106, 1182)

MVQALLSCQADVNLQDHDGSSALMLACCHGNTDMV
RLLLAHPACDSSLTDKAGRTALSIALKSP---AHVEIAGLLRAHSKQGRPLGP------

-------------------------------------------MEKTDA-KDQSSQVD-E
EKDPPKSH

PF12075 // ENSGT00530000063448_2_Domain_0 (69, 107)

PYSVETPYGFHLDLDFLKYVDDIEKGNTIKRIPIHRRA

ENSGT00530000063448_2_Linker_0_1 (107, 1014)

KQAKFSTLPRNFSL
PDGGAHPPAAPP-LQNWYPVVP--------RKASLGTQEQNQSLLL-GNAPQA--STSGS
EVSYHRRALLAEATRQLEAA-EPEDAELTLGSGRPQLLRASSMPATLLHSRAS-EEPGLS
LGPPAPPALPPFQGEGSVCD--GTFGPAEGLAG-FHSSSPQAS----------------T
WI----PELVQEGAEPPEG--------T--VKAPNHLPLPGPPFSFQNELVVLEDKEDEH
KATEAEV---VFTPGSPTPSPPPLPSPIPENELLLEEIELNISEIPPP-PPVEVDVRSIG
--IRVTEESLG---------LAGVDPGSISSLKQQVSALEGELSGRTEELAQVRAALQQQ
EEEVKAREQRIRELEFTVAQLEGQFHQENTKDTQ----------GQTDAMVNTDPVH-GL
LTRESCDKGIEVNLLGSIESESWGHRGEENGLLWGPDGHKQGNQSPAEHVLLP-QLSLPQ
GPKQV--LTPSVHSFLSTELRI--EEAGSEQE-EG--PQG----GTRGAGGFLWGSE---
-------RKTPPAGREE-ACSDLPGKEHPGRPPSSPT-DATIGQYLK--KIQEL-LQEQW
-NCL-EHGYPELASTIKQPASKLSSIQSQLLSSLNLLLSAYSAQAPPP--KEP--PASS-
----SSPPMEISPSTSLKSIMKKKDYGFRAGGN--GTKKNLQFVGVNGG-----------
YETTSSE-ETSGEDSSP----EDLSDSEAEKECDGPDHKH--VKDAHLTCEAGQGIPKGT
-----CHAAQESGPGE-----EVPYSKAERYKPSEEFLNACRAL-SQHLPETG---TTTD
QLLRQSLNTVSQEWFRVSSRKSSSPAVVA-SYLREVQPHSPHFLKLLVNLADR

PF00023 // ENSGT00530000063448_2_Domain_1 (1014, 1047)

NGNTALH
YSVSHSNFSIAKLLLETGVCNVDHQNK--AGYTAVMITPLASAETNEDMAVVWKLLREGN
V--NIQATQGGQTALMLGVSHDREDMVQA

PF13857 // ENSGT00530000063448_2_Domain_4 (1110, 1165)

LLSCQADVNLQDHDGSSALMLACHHGNVDLV
RLLLAHPACDSSLTDKAGRTALSIALKSP---THMEIAGLLRAHAEQGRSLGL------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-I----PELVREGAEHPEV--------E--EEAAHHLCLPSPPFSSQNALVVLEDAQGER
ETREAEV---VVSPESPTPSPPPLPSPIPENELPLDEIELNISEIPPP-PPVEVDVRSVG
--IRVTEESLG---------LATVAPGSISSLKQQLSDLKGELSGRAEELARVRAALQQQ
EEEVEARGHRIRELECTVAQLAEKLSHKDTKDTQ----------SQTDATVSTDPLC-AL
LIRESCDKSTGVNLLGSTGSESWGVRGEENGPLWGQDNHQQRDQSLAEFVPPP-QLSLPQ
GPERV--LTPSLRSCLSTELRI--EEAGSEQE-GD--PQRGAEGLGREAEGTSWSSD---
-------RKAPPARGEE-TSSEPPGKDRPGGPPSSPT-DATLGQYVK--KIQEL-LQEQW
-SCL-EHGYPELASTIKQPASKLSSIQSQLLSSLNLLLSAYSAQAPPQ--KEP--PAPS-
----TSPPMEISPSTSLKSIMKKKDYGFRAGGN--GTKKNLQFVGVNGG-----------
YETTSSE-ETSGEDSSP----EDLSDSEAEKKCEGAEHRR--GKDAHPDGRAGQSVSEGI
-----CRVSQESGPGE-----ELPHPKAERYEPSEEFLNACRAL-SQHLPETG---TTTD
HLLRQSLNTISQEWFRVSSRKSSSPAVVA-AYLRGVQPHSQCILKLLVNLADG

PF00023 // ENSGT00530000063448_2_Domain_1 (1014, 1038)

NGNTALH
YSVSHSNFSIVKLLLETGVCNVDTQNK--AGYTAVMITPLASAETDEDMAVVWKLLRGGN
V--NIQATQG

PF00023 // ENSGT00530000063448_2_Domain_3 (1091, 1121)

GQTALMLGVCHDRGDMVQALLSCGADVNLQ

ENSGT00530000063448_2_Linker_3_4 (1121, 1123)

DH

PF00023 // ENSGT00530000063448_2_Domain_4 (1123, 1149)

NGSSALMLACHHGNADMV
RLLLAHPACNSSLTDKAGRTALSIVLKSP---AHVEIAGLLRAHAEQGRSLGP------

-------------------------------------------MEKTDA-KDQSSQGD-E
EKDPPKSH

PF12075 // ENSGT00530000063448_2_Domain_0 (69, 107)

PYSVETPYGFHLDLDFLKYVDDIEKGNTIKRIPIHRRA

ENSGT00530000063448_2_Linker_0_1 (107, 1014)

KQAKFSTLPRNFSL
PDSGARPPAAPP-LQNWSPVVP--------REASLGTQEQNQSPPL-GNAPQA--STSRS
EVSYHRKALLAEATRQLEAA-EPEDAELTFGSGRPQLLRASSMPATLLHSRAS-EEPGLS
LGPPAPPALPPLQGEGSVCD--GTFEPAEGLAG-FHSSSPRAS----------------T
RI----PELVQEGAEPPEG--------V--VKVPNHLPLPGPPFSFQNVLVVLEDKEDEH
NAREAEV---LFTPGSPTPSPPPLPSPIPENELLLEEIELNISEIPPP-PPVEVDMRSIG
--IRVTEESLG---------LARVDPGSISSLKQQVSALEGELSGRTEELAQVRTALQQQ
EEEIKAREQRIRELEFTVAQLEGQFHQENAKDTQ----------GQTDVMVNTDPVH-GL
LTRESCDKGIEVNLLGSMESESWGHRGEENGLLWGPDGHKQGNQSPAERVLLP-QLSLPQ
GPEQV--LTSSVHSFLSTELRI--EEAGTEQE-GG--PQG----GTRGAGGFLWGSD---
-------RKTPPAGREE-TSSNLPGKEHPGRPPSSPT-DATIGQYVK--KIQEL-LQEQW
-NCL-EHGYPELASAIKQPASKLSSIQSQLLSSLNLLLSAYSAQAHPP--KEP--PASS-
----SSPPVEISPSTSLKSIMKKKDYGFRAGGN--GTKKNLQFVGVNGG-----------
YETTSSE-ETSGEDSTP----EDLSDSEAEKKCDGPDHKH--VKDAHLTCEAGQGIPEGT
-----CHAAQESGPGE-----EVPHSKAERYKPSEEFLNACRAL-SQHLPETG---TTTD
QLLRQSLNTISQEWFRVSSRKSSSPAVVA-SYLHEVQPHSPHFLKLLVNLADH

PF00023 // ENSGT00530000063448_2_Domain_1 (1014, 1047)

NGNTALH
YSVSHSNFSIVKLLLETGVCNVDHQNK--AGYTAVMITPLASAETNEDMAVVWKLLREGN
V--NIQATQGGQTALMLGVSHDREDMVQA

PF13857 // ENSGT00530000063448_2_Domain_4 (1110, 1165)

LLSCQADVNLQDHDGSSALMVACHHGNVDLV
RLLLAHPACDSSLTDKAGRTALSIALKSP---THMEIAGLLRAHAEQGRSLGL------

------------------------------------------MPPEKQS-KDQSSQGD-E
EKDRLKNH

PF12075 // ENSGT00530000063448_2_Domain_0 (69, 107)

PYSVETPYGFHLDLDFLKYVDDIEKGHTIKRIPIHRRA

ENSGT00530000063448_2_Linker_0_1 (107, 996)

KQAKFSTLPRNFSL
PNSGPRTHAASP-QQNWSPMVP--------RKISLGTQEQSQSLPL-GDVPQA--SAHGS
ELSYHRKTLLAEATRQVETG-PLED----GGSGRPQLLRASSMPATLLQNRAP-DESGLT
SGPSALLALPQLQGEGTVCD--GTFDPTKGFTG-LEA-----TTQSTDRGLEEL----EP
AI----PELVWEGAEPAEG--------G--IKASSHLSQPGPPSSVQNVPMVLGNVEIQH
QVSKAEG---VVTPGSSTPSPPPLPSPIPENELTLEEIELNISEIPPP-PPIEVDVRNIG
--IQATEESMG---------LVETDSGNTSSLKNQISALEDKLSGKTEELAQVRAALTQQ
QEETKAREERIKELECAVAQLEEKFSQGKVSDAL----------DQTDAMVNTDPLL-EL
IPRESCDKNIGVNLLRTPDPECWASRAEKNGFPWVQNSHKQGRQSPEEPVLLP-QVSLSR
GPEQV--LASSLCSCLSMELRI--EEDVSEQE-RG--PQVGAEDLSRPIGVSSWSSH---
-------RGTAAVIREE-ASSELPGAERPGRPASSPQ-DATIGQYVK--KIQEL-LQEQW
-NCL-EHGYPELASAIKQPASKLSSIQSQLLSSLNLLLSAYSAQAPEQ--KEPPAPPS--
--STTPPSMEISPSTSLKSIMKKKDYGFRAGGN--GTKKNLQFVGVNGG-----------
YETTSSE-ETSGEDTSP----EDASDGEIEKKHDCSEPRQ--DRDTHPTRETGQSVTEGA
-----GNSGQTSGSGE-----EVSHLRPERCKPSEEFLNACQAL-SQHLPETG---ATTN
YLLRESLNTISQEWFRVSSRKLSSPAVVA-AYLLE

PF12796 // ENSGT00530000063448_2_Domain_1 (996, 1056)

VQSGSPHLLKLLVNLADRSGNTALH
YSVSHSNFAIVKLLLDTGVCNVDHQNK--AGYTAV

ENSGT00530000063448_2_Linker_1_4 (1056, 1110)

MITPLASAETKEDMAVVWKLLREGN
V--NIQATQGGQTALMLGVSHDREDMVQA

PF13857 // ENSGT00530000063448_2_Domain_4 (1110, 1164)

LLSCQADVNLQDHDGSSALMLACHQGNADLV
RLLLAQPACNSSLTDKAGRTALSIVLNSP---AHVEIAELLQAHKLQKN----------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------IGQYVK--KIQEL-LQEQW
-LCL-EHGYPELASAIKQPASKLSSIQNQLVNSLNSLLSAYSSQGPVD--KENS------
-NTHYQQL-ENSPTTSLKSIMKKKGYGFHAGGN--GTKKNLQFVGVNGG-----------
YETTSSEEDTSCEDSDT------ETEG---RAGGDVEPE--QPGRESRGDSSGEKCEDDD
DDDEEEEEEQEASAG----AAPCSQHQAHRCKPSEDFLAACQLL-SEHLPEIR---SRSN
KHLQHVLASISHEWFQVSSHKSSRPEVVA-AYLEALRDIQPQLLEAVVNLPDR

PF00023 // ENSGT00530000063448_2_Domain_1 (1014, 1040)

NGNTALH
YSVSHSNFQVAKLLLDTGVSCLDLQNR--AGYTAVMLTPLAAPETRQDMEVVMRLLREGD
V--NLRAAQG

PF00023 // ENSGT00530000063448_2_Domain_3 (1091, 1121)

GQTALMLGVWHDRPDMVRALLSCRADVNVQ

ENSGT00530000063448_2_Linker_3_4 (1121, 1124)

DEE

PF00023 // ENSGT00530000063448_2_Domain_4 (1124, 1150)

GSTALMLACRRDNADIA
RLLLAQPGCLLTLTDKGGNSALSLA--------HGDVAALLRAHIELSPSLPV------

--------------------------------------------------QDQPVHGG-E
EKDSPKGH

PF12075 // ENSGT00530000063448_2_Domain_0 (69, 107)

PYSVETPYGFHLDLDFLKYVDDIEKGNTIRRVPIHRRAKQAQFSTLPWNFSL
PHGGVRPQAALV-QQHWSPMV--------PGKVSLGPKVQTQPLAPQGRNPQA--SAGGS
ELSHPRKALLVDAAGRR------EDEAPGLVSARPQLLRASSVPATLPSSRAV-------
ERFPAPPAPPPLQDIGGTWD--SSFRPAEGPAG-SSKAS---------------------
-A----DHTAEELGGRVLGAPEKAEHPAGEVQAPDHPPPPGSSPSFQSAPAILEDMGGKA
QTRGTQG---LSTPGSSTPSPAPLPSPAPESDLALVEMELSISELPLP-PPPEIAVRSTG
--VQVTAEALGPDRS----------------LGQQLSVLQGELASCTEELAAARAAL---
----EAREQRVRELEGTVAQLEGKLSQDAQ--------------GHTHAAVSTGPLC---
--VETCHRGVGDASLSPADSGGRGA-LGEEGSLL-----RVTDSAPPGEQRPA-QLSLPQ
GPGTS--PVSPVHGCLSMELRI--EESAGSGQEWD--AGLAAEGTSG--------SD---
-------REAALVAGEE-ASPKHP----GGPPR-SPS-DAALGQYVR--KIQEL-LQEQW
-SCL-EHGYPELASALRQPASRLSSIRGQLLSSLSLLLSACAAQGPQQEPEGRPGPSP--
------PAPEISPPTSLKSIMKKKDYGFRAGGN--GTKKNLQFVGVNGG-----------
YETTSSE-ETSGEDSSP----EDLSDREAGEECDDP--ERVQDRDAHAGQ----GHPEQV
-----PSSGDRN-----------VFVLFSRCQPSEEFLCACQVL-SQHPLEAGA----TD
PLWRQSLNTISQEWFHVSSRKSSSPAVVA-AYLLEVQTLSQHLLKLLVNLADRSGNTALH
YSMSYSNFAIVKLLLDTGVCAVDHQNK--AGYSAVMITPLASAETDEDMAVVWRLLREGN
V--NIQATQ---------------------------------------------------
-----------------------------------------------------------

-------------------------------------------MEKTDA-AGQPPLPN-G
DGEQPRSL

PF12075 // ENSGT00530000063448_2_Domain_0 (69, 106)

PYSLETPYGFHLDLDFLKYVDDIEKGNTIRRVHIHRK

ENSGT00530000063448_2_Linker_0_1 (106, 1008)

AKQPKFSTLPRNFSL
PENGSHGYAAST-GPGWPAATYRAQ-----RKASLGAEEISRAPLP-----------SE-
EPSYRRKALLAETRRHAELV-RCED----ELRGRPQLLRASSLPAALPPGQAP-ASDGCV
PCPLR-------PSDNGSCPES-TFRPMPRSPDGIASLPSLML--SPGAELASQ-QQEWP
GK----GGLVR---------------DVPKER--AQPLWQGQHSAV-QLQVVMESRGEEG
DASDATN-------GSTLVSASPGALQLADESTNHGKAGGSVSEIALN-VLKEGEDRCAH
--AQEKKEQGG----------DAGEPGGIAALKQHIAALEEQLDRKKEELEQIRAVLKQQ
DHKIKEKEKSIQLLASSKAQLEGQLCRENTREDAVSSMQRGSMLQCNDVAVNTELSY-VN
GSKQVHDKGINVNIPLSTKSIGCGIRRADNGNLLAAELSAQGWADVGTSGGGD--GHFAK
LSETEAGLEPGLHAPGFTELKI--DEQLSDDNQNQRNSCDTQSLAARAAAAESYRTKRT-
---GSSADENEAGFGED-KTEDGMGEEGLPDPKDFPA-VDPIGQYVK--KIQEL-LQEQW
-MCL-EHGYPELASAIKQPASKLSSIQNQLVNSLNSLLSAYSSQRPAD--KENS------
-NTHYQQL-ETSSTTSLKSIMKKKGYGSHAGGN--GTKKNLQFVGVNGG-----------
YETTSSE-DTSCEDSPS----DGDMESDTERGAGGLEPTQEQGGGGSEGASFVTSVQ---
-ETREDDDLQEPGAE----TAPCTQHKADSCKPSEDFLAACQLL-SQHLSEI--RA-TSD
QHLRHVLSTICQEWFQVSSRKSSSPEVVT-AYLQALGTIQLQLLEAV

PF13637 // ENSGT00530000063448_2_Domain_1 (1008, 1035)

VNMADRNGNTALH
YSISHSNFTIAKLLLDTGRSSSSLLSNGFVGYGCGSCFVLPAW-----------------
------QGHGGQSQAMGSMNGPRCSKW---------------------------------
-----------------------------------------------------------

MVVPGAKKFPRHQEAFMQKNAPMNFTDLLDEECLRNWRPAFPKMEKTDA-KDQSSQRE-E
EKEPPKGH

PF12075 // ENSGT00530000063448_2_Domain_0 (69, 107)

PYSVETPYGFHLDLDFLKYVDDIEKGNTIKRIPIHRRA

ENSGT00530000063448_2_Linker_0_1 (107, 1001)

KQAKFSTLPRNFSL
PDSGARPHAALS-HPNWSPAVP--------RKASPGPEARAHSLLL-SEPPA---AASGG
DVSYRRKVLLAETARQVEAA-APPELELVSGSARPQLLRASSMPATLLPNRAS-EDPSLN
SGSPVPLALPPLQGEGGVCD--GAFGPAEGFLASFHSSTPGTAPQPEVRELGDL----VP
GI----PERIQEAAEPPEG--------E--GEALNHLSLPSPLFSPPNVLVVLEDAEEQH
EGGEAEA--GVTTSGSPTPSPPPLPSPIPENELSLDEIELNISEIPPP-PPVEVDVRSIG
--IRVTEESLG---------LASVDPGSIPSLKQQLSDLESELSERTEELAQVRAALQRQ
EEEIQARGQRIQELERTVAQLAEKLSRRNTKEAQ----------GQTDAMVNTDPLH-GL
LTRESCDKSIGVNLMGSMGSESWGARGEGNGFLWWQDSHKGGDRSPAELVPPP-QLSLPQ
GPEVG--LPPSLHSCLSTELRI--EEGGAEQE-GG--PQVEAESLVRGAGGSPGSSK---
-------RQAPPEGRGE-AGSELPGKERPGRPPSSPT-DATIGQYVK--KIQEL-LQEQW
-SCL-EHGYPELARAIKQPASKLSSIQSQLQSSLNLLLSAYSAQAPPQ--KEP--PGPS-
----SSPPMEISPSTSLKSIMKKKDYGFRAGGN--GTKKNLQFVGVNGG-----------
YETTSSE-ETSGEDSSP----EDLSDSEAEKTCDGPEHRR--GKDAHLSGKAGQAVAEGT
-----CHTGQESGPGD-----ELSHPKAERYQPSEEFLNACRAL-SQHLPETG---TTPD
QLLRQSLNTISQEWFRVSSRKSSSPAVVA-AYLRGVQPHS

PF12796 // ENSGT00530000063448_2_Domain_1 (1001, 1056)

PHLLRLLVNLADNNGNTALH
YSVSHSNFSIVKLLLETGVCNVDHQNK--AGYTAV

ENSGT00530000063448_2_Linker_1_4 (1056, 1110)

MITPLASAETDEDMAVVWKLLREGN
V--NIQATQGGQTALMLGVSHDREDMVQA

PF13857 // ENSGT00530000063448_2_Domain_4 (1110, 1164)

LLSCQADVNLQDHDGSSALMLACCHGNTDMV
RLLLAHPACDSSLTDKAGRTALSIVLKSP---AHVEIAGLLRAHAKQGRSLGP------

-------------------------------------------MEKTDA-KDQPSQGD-E
EKGPPKSH

PF12075 // ENSGT00530000063448_2_Domain_0 (69, 107)

PYSVETPYGFHLDLDFLKYVDDIEKGNTIRRIPIHRRA

ENSGT00530000063448_2_Linker_0_1 (107, 1015)

KQAKFSTLPRNFSL
PDSRARPHAALS-HQNWSPVVP--------RKVLLGTEERAQSLPP-GEYPQA--SASGS
EVSYHRKALLAETARHLEAA-APREAETASGSGRPQLLRASSMPATLLQNKAS-EDSSLN
SGSPMPPALPLLQSEGSVCD--GTFGPADGFAG-FQNSTPRATTQPKVREFGDL----VP
GI----PELVQEGTELPEG--------EDEEEAPNHLSLPSPPFFSQDALVVLEDEEDEP
KTREAEV---VVSPGSPTPSPPPLPSPIPENEFPLEEIELNISEIPPP-PPVEIDVRSIG
--IRVTEESLG---------LPAVDPGSISSLKQQLSALEGELSGRTQELAQVRAALQQQ
EDESKARGQRIQELECTVARLAGKLSHENTRDSQ----------GQTDAMVNTDPLN-GL
LTRESCDKSIEVNLLGSTGSESWRARGEGNGLLWGQAGHKPGDRSPPKLVPPP-QLSLPQ
GPEMV--LPTSLHSCLSTELRI--EEAGSEQE-GS--PQVGAEGLGRAAGGSSWSSD---
-------RKTPPAGREE-ASSEPLGKERPGRPPSSPP-DATIGQYVK--KIQEL-LQEQW
-SCL-EHGYPELASAIKQPASKLSSIQSQLLSSLNLLLSAYSAHAPPQ--KGPPAPSA--
-----SPPMEISPSTSLKSIMKKKDYGFRAGGN--GTKKNLQFVGVNGG-----------
YETTSSE-ETSGEDSSP----EDLSDSEAEKKCDGPEHRR--GKEAHNTCKAGQGIPEGI
-----SSTGQESGPGG-----DLPHPKAERYKPSEEFINACRAL-SQHLPETG---ATTE
QLLRQSLNTIRQEWFRVSSRKSSSPAVVA-AYLRGVQPHSPHFLKLLVNLADGN

PF13637 // ENSGT00530000063448_2_Domain_1 (1015, 1056)

GNTALH
YSVSHSNFSVVRLLLETGVCNVDHQNK--AGYTAV

ENSGT00530000063448_2_Linker_1_3 (1056, 1068)

MITPLASAETDE

PF12796 // ENSGT00530000063448_2_Domain_3 (1068, 1146)

DMAVVWKLLREGN
V--NIQATQGGQTALMLGVSHDREDMVQALLSCQADVNVQDHEGSSALMLACRHGNADMV
RLLLA

PF12796 // ENSGT00530000063448_2_Domain_4 (1068, 1146)

DMAVVWKLLREGNV--NIQATQGGQTALMLGVSHDREDMVQALLSCQADVNVQDHEGSSALMLACRHGNADMVRLLLAHPACDSSLTDKAGRTALSIVLKSP---AHVEIAGLLRAHAEQGRSLGP------

-------------------------------------------MEKADA-KDQPSQGD-E
EKDPPKSH

PF12075 // ENSGT00530000063448_2_Domain_0 (69, 107)

PYSVETPYGFHLDLDFLKYVDDIEKGHTIKRIPIHRRA

ENSGT00530000063448_2_Linker_0_1 (107, 1002)

KQAKFSTLPRNFSL
PDSGARTYAAPP-QQNWSPVVP--------RKISLGIQEQSQSLPL-GDVPQA--SGHGS
ELSYHRKVLLAEGMRQVEAG-ALED----GGSGRPQLLRASSMPATLLQNRAP-DEPSLT
SGPSTLLALPLLQGEGSACD--RAFDPAEGFTG-FQA-----STQSTDRGLGEL----EP
AI----PELVWEGVEPEEG--------D--IKASSHLSQPGSPSSVQNVPMVLENMGIQH
QARKAEV---VLTPGSSTPSPPPLPSPIPENELSLEEIELNISEIPPP-PPIEVDVRCIG
--IQVTEESLG---------LAGTDTNSISSLKNQFSALEDKLSGRTEELTQVRAALAWQ
QEETKAREQRIQELECTVAQLEEKLSQEKASDAL----------DRTDATVNTDPLL-EL
IPRESCDKNIGVNLLRTPDPECWTSTAERNGFPWVQNSHKRGHQSPEGPVLPPTQLSLSR
GPEQV--LASSLCSCLSMELRI--EEDVSEQE-RG--SQVGAEDLSRVTGASSWSST---
-------RESASVIREE-ASSELPGAERPGRPASSPQ-DATIGQYVK--KIQEL-LHEQW
-NCL-EHGYPELASAIKQPASKLSSIQNQLLSSLNLLLSAYSAQAPEQ--KEPPAQPS--
--ATPPPPPEISPSTSLKSIMKKKDYGFRAGGN--GTKKNLQFVGVNGG-----------
YETTSSE-DTSGEDSSP----EDVSDSETEKKRDCSEPRQ--GRDTHPPREAGQDVPEGT
-----GNSGQTSGSGE-----EVSHLRPERCKPSEEFLNACQAL-SQHLPETG---ATTK
QLLRQSLNTISQEWFRVSSRKLASPAVVAA-YLLEVQ-PHS

PF13637 // ENSGT00530000063448_2_Domain_1 (1002, 1035)

HLLKLLVNLADRSGNTALH
YSVSHSNFAIVKLLLDTGVCNVDHQNK--AGYTAVMITPLASAETKEDMAVVWKLLREGN
V--NIQATQGGQTALMLGVSHDREDMVQA

PF13857 // ENSGT00530000063448_2_Domain_4 (1110, 1164)

LLSCQADVNLQDHDGSSALMLACHQGNADLV
RLLLAHPDCNSSLTDKAGRTALSIVLNSP---AHVEIAELLQAHSEQGRSLGLKLQKQ-

-------------------------------------------MEKTDA-KDQSSQGD-E
EKDPPKSH

PF12075 // ENSGT00530000063448_2_Domain_0 (69, 107)

PYSVETPYGFHLDLDFLKYVDDIEKGNTIKRIPIHRRA

ENSGT00530000063448_2_Linker_0_1 (107, 1008)

KQAKFSTLPRNFSL
PDSGARPPAAPP-LQNWSPVVP--------RKASLGTQEQNQSPPL-GNAPQA--STSRS
EVSYHRRALLAEATRQLEAA-EPEDAELTFGSGRPQLLRASSMPATLLHSRAS-EEPGLS
LGPPAPPALPPLQGEGSVCD--GTFEPAEGLAG-FHSSSPRAS----------------T
RI----PELVQEGAEPPEG--------M--VKVPNHLPLPGPPFSFQNALVVLEDKEDEH
NAREAEV---LFTPGSPTPSPPPLPSPIPENELLLEEIELNISEIPPP-PPVEVDMRSIG
--IRVTEESLG---------LARVDAGSISSLKQQVSALEGELSGRTEELAQIRAALQQQ
EEEIEAREQRIRELEFTVAQLEGQFHQENAKDTQ----------GQTDAMVNTDPVH-GL
LTRESCDKGIEVNLLGSMESESWGHRGEENGLLWGPDGHKQGNQSPAERVLLP-QLSLPQ
GPEQV--LTSSVHSFLSTELRI--EEAGTEQE-GG--PQG----GTRGAGGFLWGSD---
-------RKTPPAGREE-ASSNLPGKEHRGRPPSSPT-DATIGQYVK--KIQEL-LQEQW
-NCL-EHGYPELASAIKQPASKLSSIQSQLLSSLNLLLSAYSAQAHPP--KEP--PASS-
----SSPPVEISPSTSLKSIMKKKDYGFRAGGN--GTKKNLQFVGVNGG-----------
YETTSSE-ETSGEDSTP----EDLSDSEAEKKCDGPDHKH--VKDAHLTCEAGQGIPEGI
-----CHAAQESGPGE-----EVPHSKAERYKPSEEFLNACRAL-SQHLPETG---TTTD
QLLRQSLNTISQEWFRVSSRKSSSPAVVA-SYLHEVQPHSPHFLKLL

PF13637 // ENSGT00530000063448_2_Domain_1 (1008, 1035)

VNLADRNGNTALH
YSVSHSNFSIAKLLLETGVCNVDHQNK--AGYTAVMITPLASAETSEDMAVVWKLLREGN
V--NIQATQGGQTALMLGVSHDREDMVQA

PF13857 // ENSGT00530000063448_2_Domain_4 (1110, 1165)

LLSCQADVNLQDHDGSSALMLACHHGNVDLV
RLLLAHPACDSSLTDKAGRTALSIALKSP---THMEIAGLLRAHAEQGRSLGL------

-------------------------------------------MEKIDG-KDQSSQGD-E
EKEPPKSY

PF12075 // ENSGT00530000063448_2_Domain_0 (69, 107)

PYSVETPYGFHLDLDFLKYVDDIEKGHTIKRIPIHRRA

ENSGT00530000063448_2_Linker_0_1 (107, 1005)

KQAKFSTLPRNFSL
PNSGHRTHAVPP-QQNWSPVVP--------RKISLGTQEPSQSLPL-GDLPQA--SVQGS
ELNYHRKALLAKDARQVEAG-SLED----VGSGRPQLLRASSMPATLLQNQVP-EEPSLT
SGPSTLLALPLLQDEGSVCD--GAFDPAEGLMG-FQA-----SAQSVNRELGEL----EP
AI----PEQVWEGAEPEEG--------D--LKASSHLSQPGPSSTVQSVPMDLEEVEIQH
HMREAEL---VLTPGSATPSPPPLPSPILENDLSLDEIELSISEIPPP-PPIEVDVRSIG
--IRVTEESLG---------LLETGTSSISSLKNQVLALEDKLSGRTEELARVRAALEQQ
EEETKAREQRIQELECTVAHLEEKLSQERASEAP----------DRTDATVNTDPLQ-EL
TPRESHDKNIGVNLLNTPDPECRAPRAEKNGFPWVQNNHKQSYPSPEEPVLPP-QLSLPR
GPEQI--LASSLCSCLSMELRI--EEEGSEQE-GG--PEEGAGGLSRAAGESSWST----
-------RESAPVIREE-ASSELPGAERPGRPASSPQ-DATIGQYVK--KIQEL-LHEQW
-NCL-EHGYPELASAIKQPASKLSSIQNQLLSSLNLLLSAYSAQAPEPEPKETPAPPPST
PPPP-PLPPEISPSTSLKSIMKKKDYGFRAGGN--GTKKNLQFVGVNGG-----------
YETTSSE-ETSGEDSSP----EDLSDSETEKKQDCSESGE--DRDLHPSCEAGQGVPEGT
-----RNSGHTSDRGE-----EVSHLRADRYKPSEEFLNACQTL-SQHLPETG---DTTK
QLLRQSLNTISQEWFRVSSRKLSSPEAVA-AYLREVQPHSPHLL

PF13637 // ENSGT00530000063448_2_Domain_1 (1005, 1035)

KLLVNLADRSGNTALH
YSVSHSNFAIVKLLLDTGVCNVDHQNK--AGYTAVMITPLASAETKEDMAVVWKLLREGN
V--NIQATQGGQTALMLGVSHDREDMVQA

PF13857 // ENSGT00530000063448_2_Domain_4 (1110, 1164)

LLSCQADVNLQDNDGSSALMLACHQGNADLV
RLLLAHPACNSSLTDKAGRTALSLVLNSP---AHVEIAELLRAHSEPGRSLGPKELQKN

-------------------------------------------MEKTEA-DGQPLKPD-G
DREQPRSL

PF12075 // ENSGT00530000063448_2_Domain_0 (69, 107)

PYSLETPYGFHLDLDFLKYVDDIEKGNTIRRVHIHRRAKQPKFSTLPRNFSL
PESGSRACPSAAPSKSWTSTSPRDAGLGSPRDAGLGSPRDAGLSQP-----------RDA
EPSRSR-DAEMGYPRDAEIA-SPRD----ALRARPQLLRASSLPDALPPGQSP-PAG---
ASPLRT---PPQHCREQGGSESIAWR----GSDSSA------V--TPPREMRSE-QDGPL
GQPGPLGQPGSLGQP--D--------GVVPGPGPAQPPWLNQ-----QLQVVMESGGEEG
DAAEMGG-------GEA------AALQLAGENGSPAGTGLGVSEMDLK-VLKEGEERDVQ
--AEEDEGSGD----------PQAPEAGVTALKQQIAHLQQQLARKKEELEQVRAVLEQQ
DQEIQEKERSIKLLASRKAELEEQLCREKCKGSG--------ARPCRDAAVNTEPWQ-PA
GLGLGQDKAISADIPLPGGSAR---------------------------GGEQ--GP---
----APARPAGAAAPCFAPLQI--HEHPGDHNRNRQNQ----------------------
---QNSTAEREAGFGEE-KPR-----EGAPGHEDVPA-VDPIGQYVK--KIQEL-LQEQW
-LCL-EHGYPELASAIKQPASKLSSIQNQLVNSLNSLLSAYSSQGPVD--KENS------
-NTRYQQLVENSPTTSLKSIMKKKGYGFHAGGN--GTKKNLQFVGVNGG-----------
YETTSSE-DSSCEESDS----DTETEG---R-AGDVEPE--QAGRENKGASSGQKSEDDD
DGDG-DDAGQEESAG----AAPCSEHQAHRCKPSEDFLAACQLL-SEHLPEIR---STSN
KHLQPVLASISQEWFQVSSHKCSSPEVVA-EYLEVLGDIQPQLLEAVVNLPDRNGNTALH
YSVSHSNFPVAKLLLDTGMCCLDLQNR--AGYTAVMLTPLAVPETRQDMEVVMRLLKEGD
V--NLRAAQG

PF00023 // ENSGT00530000063448_2_Domain_3 (1091, 1121)

GQTALMLGVSHDRDDMVRALLCCQADVNLQ

ENSGT00530000063448_2_Linker_3_4 (1121, 1124)

DEE

PF00023 // ENSGT00530000063448_2_Domain_4 (1124, 1147)

GSTALMLACRQGNADMV
RLLLAQPGCRVTLTDKGGNSALSLA--------HGDIAALLRAHVELSPSLAV------