Query Results 

--------------------------------------------------------MKRI
FSCSSSQVA-------------------VEKWNRRDQKLL

PF12796 // ENSGT00530000063369_3_Domain_1 (101, 202)

EAVQRGDVGRVAALASRKSA
RPTKLDSNGQSP---FH---LAASKGLTECLTILLANGADINSKNE-------DGSTALH
LATISCQPQCVKVLLQHGANE

ENSGT00530000063369_3_Linker_1_3 (202, 211)

DAV---D-A

PF12796 // ENSGT00530000063369_3_Domain_3 (211, 287)

ENRSPLHWAA---SSGCASSVLLLCDHEAF
LDVLDN---------DGRTPLMIASLGGHAAICSQLLQRGARVNVTDKDDKSALILACEK
GSAEVAELLLSHGADAGAVDSLGHNALHYALGTQDRELWRLLQQALNRRRRG-GRELVQH
PDHAS----QASSSE---------------------SPWRAEPEEEQEEE--KGEERG-S
EEWRWKFEEEQRKVHQLEQELLQKTDECKARAAAFVSLENQIREQVQELGYLLVQVPGAP
RN-QGPGLRPEGDGMEQGCP---LNLLAEWIQELKKQQKATAT----INPTLVPKRAEDL
--A-PAETHYEVPGKFQP-E-QGL-SQSPRSETIGKATGQQLNTNGE-------QNLDLD
NTEQVCADQKERA-------------LAPGTEPAVTVGEPVGIA-A-MNQLLLQLREELA
-AVWREK-D---AARGALSRPVLEGALGTPRAEAAAAAWEKMEARLEKVLVRLDGAKMGL
HVKPEVPAQ---GSRDGAPKIVQGCTK------E---QEGKRAPG-ARGEPLGAPGGE--
---QA-LGGGLAKGQLEKEVSALRLSNSNLLEELEELGRERQRLQGELQSLTQKLQREFV
PKPEAQVQLQQLRRSVGLLTEELAIEKEATEKLRRRLASQTSGLQGLWNCFPPDLVGKGS
A-R--STAAEPLEELQACISTLVDRHLESQQVQARLEEENQRLRGSLPP--CGEP-EASL
--KATASPQVAALEEDLGKLEEELRAVQATMSG--KSQEICKLKQLLYQATEEVAELRAR
EAASLRQHEKTRGSLVAQ----AQAWGQELKVMLEKYNTACREMTRLRDTAAEERRRSEE
LAARAAEQERQAGEMRGRSEQFEKTAELLKEKTNHLIGACRDKESKIKELLKKLEQLSEE
VLEVRAENTHL-VLQLQDTQKNHEEIISTYRNHLLNAARGYMEQDVYNILLRILSVQE--
----------

--------------------------------------------------------MKRI
FSCSSSQVA-------------------VERWNRRDQKLL

PF12796 // ENSGT00530000063369_3_Domain_1 (101, 198)

EAVQRGDVGRVAALASRKSA
RPTKLDSNGQSP---FH---LAASKGLTECLTILLANGADVNSKNE-------DGSTALH
LATISCQPQCVKVLLQQAAGT---------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------VNSVLAPKKAEDS
---APGEIQCAVHGRSQP-EEQEL-PQSPGSETIRKATRQQLTKDGG-------QTLGPD
HADQMPAGQKERP-------------RVPGVEPGGTVAEPAGPA-A-MTQLVLQLREELA
-AVWREK-D---AARAALSRPVMEGALGTPRAEAAAAAWEKMEARLERVLARLDRAKAGL
QVKPEVPAQ---ESRERAPKAAPGSIK------E-DEEKEKSVPG-ARGDSLGAPGGE--
---QA--LGGLAKGQLEKEVSALRLSNSHLLEELGELGRERQRLQRELQSLSQRLQREFV
PRPEAQVQLQQLQQSVGLLTDELAVEKEATEELRRRLASQSSSLRGLWDCLPADLAGKRS
AAR--SEVAEPPEELRACISTLADRHREAQHVLAQLREENRQLRGSLSP--GGEP-GTSF
--KVPASPQVAALEQDLGKLEAELRAVQATMSG--KSQEIAKLKQLLYQATEEVAELRAR
EAASLRQHEKTRGSLVAQ----AQAWGRELKALLEKYNAACRELARLREAVAEERRRGGD
LAARAAEHERQASEMRGRSEQFQKTAELLKEKMERLVGACRDKEAKIKELLKKLEQLSEE
VLAVRGENARL-ALQLQDSQKNHEEIISTYRNHLLNAAQGCMEQDVYSILLRILSMQEE-
----------

--------------------------------------------------------MKRI
FSCSSSQVA-------------------VEKWNRRDQKLLEAVQRGDVSRVAALASRKNA
RPTKLDSHGQSPTARFH---LAASKGLTECLSVLLANGAEINSKNE-------

PF00023 // ENSGT00530000063369_3_Domain_2 (174, 208)

DGSTALH
LATISCQPQCVKVLLQHGANEDAV---D-GENRSPLHWAA---SSGCASSVLLLCDHEAF
LDVLDN---------D

PF00023 // ENSGT00530000063369_3_Domain_5 (257, 288)

RRTPLMIASLGGHAAICSQLLQRGARVNVTD

ENSGT00530000063369_3_Linker_5_6 (288, 292)

KEDK

PF00023 // ENSGT00530000063369_3_Domain_6 (292, 320)

SALILACEK
GSAEVAELLLSHGADVGTVDIMGHDALYYALRTQDEELWRLLRQALNRRQRG-GQERAQH
PDSASQVKSQTLPSEHPC-------------GSPPKSPRRAEAEEDEDEKEEEGEDLCSP
QEWRKKYEAEKKKVSQLEQELIKKAQECKAQESACQGLESRVREQVQELGVLLARESRAP
CG-QGSSPRPGGDGMEQGCV---LDLLAEQVQELKRQKEAMTL--KGSE----------S
R-G----PQGESQGTTQA-EEQRPQLLSPAGKTPRKAKGEKVVNVGGVV-------SSQG
RGDQVLPLKEERG-------------KALGVEPAGMV--------A-LGQLLLQLREELT
-AVWRDK-D---AARGVLGRPAGNRVWGASQAEAAAAAWEKMEARLEQVLARLDRAKAGL
NVEAVPPVL---GSPEGAPLPQAKAVTV-MVSPTREGKAKERAHE-TRGEPLGAPGAG--
---QAPEG-TGGKGQLEKEVSALRLSNSNLLEELSELGRERQRLQGELQALGQRLQKEYM
PRPEAQGQLQQLRSSVGLLAEELAAEKEAAEQLRRRLAAQSTGLQGLRECLPPNLVGGGS
L-Q--GPAPDPLEELQGCVGALVAKYNEAQRELAKLEGENRRLKGNG-----------SV
--ASRAVPQVAALEQDLGKLEEELRAVQATMGG--KSQEIGKLKHLLYQATEEVAELRAR
EAANLKQQEKSRASLVAQ----AQTWGQELKALLEKYNSACRETGQLREVVAEERRRSRE
LAARAAEQERRANEMRGRSEQFERAGEILKEKMEQLIGACREKEAKIRELLKKLEQMSAE
VLAVRGENTRL-RLQLQDSQKNHQEIISTYRNHLLNAAQGYMEQDVYKILLRILKMQE--
----------

--------------------------------------------------------FLFA
FSCS-----------------------AVERWNRRDQKLLEAVQ-------------KS

PF13857 // ENSGT00530000063369_3_Domain_1 (120, 182)

A
RPSKLDSNGQSP---FH---LAASKGLTECLSVLLANGADINSKNE-----------DGE
L

ENSGT00530000063369_3_Linker_1_3 (182, 190)

HRL--HAA

PF12796 // ENSGT00530000063369_3_Domain_3 (190, 287)

SLCDYLQHGANEDAV---D-AENRSPLHWAA---SSGCASSVLLLCDHEAF
LDVLDN---------DGRTPLMIASLGGHAAICSQLLQRGARVNVTDKDDKSALILACEK
GSAEVAELLLSHGADAGAVDSRGHDALHYALCTQDKTLWRLLQQALNRRRRG-GQRLVQH
PDLAS----QASSSEPHV-------------GSPLKSPWRAEPEEEQKEE--EDEDPC-S
KEWKWKYEEEQKKVSQLEQDLVRKTEECKAQAAAFLGLESQIREQVQELGLLLSQEPRAP
RG-HGSRLRPGGDGMEQGCP---LDLLAEHIQELKKQQQAAAIVNQEAKRV------E-E
N-SAAGEIQHEVHGKSPP-EEQGP-PQSPRSEATRKSTEQQLTGGP--------HTLVPD
HTGQQPADQKARP-------------QASGVEATDAVAEPVDTA-A-MNHLLLQLREELA
-AVWRDK-D---AARGALSRPVLGEPLGTPR---------KMEARLERVLVRLDRAKAGL
QGKPEVPGQ---ESRAGAPKAAPGCIK--------EHGEEELAPG-ARGEPLGAPGEQ--
---F-P-GGGLPKGQLEKEVSALRLSNNNLLEELRELGCERQRLQGELQSLSQRLRGEFV
PKLEAQVQLHQLQRSVGLLTEELAMEKEATEKLRKRLASQSSGLRGLWDCLPPDLVGTGR
A-R--SAEAEPLAELRACITALADRQREAQRALAGLEEENRRLR----------------
---------------------EELRAVQAAMSG--KSQEMAKLKQLLYQATEEVAELRAQ
EAASLRQHEKTR-LLVAQ----AQAWGQELKDVLEKYNAACREMGRLREAAAEERRRSDD
LAARAAEQERRASELRGRSEEFEKTAEGLKEKTERLMEACRDKKAKIKELLKKLEQLSEE
VLSVRGENARL-ALELQDSQKSNEEIITTYRNHLLSAAQGYMEQDVYNVLLRILSMQEE-
----------

--------------------------------------------------------MKRI
FSCSSSQVA-------------------VERWNRRDQKLL

PF12796 // ENSGT00530000063369_3_Domain_1 (101, 202)

EAVQRGDVGRVAALASKKSA
RPTKLNSNGQSP---FH---LAASKGLTECLTILLANGANINSKNE-------DGSTALH
LATISCQPQCVKVLLQHGANEDAV---D-AENRSPLHWAA---SSGCASSVLLLCDHEAF
LDVLDN---------DGRTPLMIASLGGHAAICSQLLQRGARVNVTDK

PF12796 // ENSGT00530000063369_3_Domain_6 (289, 342)

DDKSALILACEK
GSAEVAELLLSHGADAGAVDRTGHDALHYALHTQDKALWGLLRQAWQRRRQG-GQGLVLH
PDLAS----QASPSEPQV-------------GSPPKSSWRAESEEEQEEE--EDEDPC-L
EEWIWKYEEERKKVSQLEQELVRKTEECKAQEAAYLGLENQIREQVQELGFL-SQELGVS
GG-QSATLWP-GDGMEQGRP---LDLLAECIQELKQQQAAATA------NPLAPKRVEES
---TPEEIQNEVRGRSQP-EQ-GS-ARSPMSEVIGKATGQQLTTSQG-------QILDPD
HTNQLCAGQRERL-------------QAPGVEPVGTA--------A-MNQLLLQLREELA
-AVWREK-D---AARGALSRPILEGALGTPRAEAAAAAWEKMEARLERVLVRLDRAKAGL
EVRPQAPAQ---EDKTGVPKADPACIT--------EHPEETKAPG-ARREPLGDSGGE--
---QAP-GGGLAKAQLEKEVSALRLSNSSLLEELGELGRERQRLQGELQSLSQRLQREFV
PKPEAQVQLQQLRRSVGLLMDELAMEKEATEKLRKHLASQSSGLRGLWDCLPPDLVGKGR
A-R--TRASEPLEELQVCVGTLAERHRQAQHKLARLEAENQQLRGSLTP--SREL-GAPS
--EVPVSPQVAALEQDLGKLEEELRAVQATMSG--KSQEIGKLKQLLYQATEEVAELRAR
EAASLRQHEKTRGSLVAQ----AQAWGQELKAVLEKYNTACREMGRLREAAAEERRRSQD
LAARASEQEGQASEARARAEQLEKTVEQLKEKVEHLTGACRDKEAKIKELLKKLEQLSEE
VLAVRGENTRL-ALQLQDSQKNHEEVISTYRNHLLNAARGYMEQDVYTILLRILSIQEE-
----------

--------------------------------------------------------MKRI
FSCSSSQVA-------------------VERWNRRDQKLLEAVQRGDVGRVAALASRKSA
RPTKLDS

PF00023 // ENSGT00530000063369_3_Domain_1 (128, 166)

NGQSP---FH---LAASKGLTECLTILLANGADINSKN

ENSGT00530000063369_3_Linker_1_2 (166, 174)

E-------

PF00023 // ENSGT00530000063369_3_Domain_2 (174, 210)

DGSTALH
LATISCQPQCVKVLLQHGANEDAV---D-

ENSGT00530000063369_3_Linker_2_3 (210, 211)

A

PF00023 // ENSGT00530000063369_3_Domain_3 (211, 246)

ENRSPLHWAA---SSGCASSVLLLCDHEAF
LDVLD

ENSGT00530000063369_3_Linker_3_5 (246, 256)

N---------

PF00023 // ENSGT00530000063369_3_Domain_5 (256, 288)

DGRTPLMIASLGGHAAICSQLLQRGARVNVTD

ENSGT00530000063369_3_Linker_5_6 (288, 289)

K

PF00023 // ENSGT00530000063369_3_Domain_6 (289, 321)

DDKSALILACEK
GSAEVAELLLSHGADAGAVDSMGHDALHYAQLTQDKALRKLLRQALNRQRRG-GQGLVQH
PDLVS----QASSSEPQV-------------GSPPKSPWRADPEEEQEEE--EDEGQC-S
EEWRCKYKEEQRKVCQLEQELVQKTEECKAQAAAYLGLENHIREQVQELGLLLAQEPGAP
GG-QDSSVQPGGEGMEQGCP---LDLLTEYVQELKKQHQATAT----VNSAFTPKRAEDS
A-PAGREIQCPVQGTSPP-RDRGL-PQSPRPETIKKATEQTLSSKGQTTN--RAQILGPA
HPNQQ--GTSQVW-------------QAPAGEPADTATSPKGTA-A-LTQLLLQLREELA
-AVWREK-D---AAWGALSRPVLEGALGTSRAEAAAAAWEKMEARLEQVLVRLDRAKAGL
QVKAEVPEP---EFRQGDPKATPRRSR------KD--EEEKRALG-PRGEPLGAVGEE--
---PSPGGTVLAKGQLEKEVSALRLSNSNLLEELGELGRERQRLQGELQSLSQRLQQEFV
PKPEAQVQLQQLRHSVGLLTDELALEKEATEKLRKRLASQSSGLRGLWDCLPPDLVGKDG
P-R--SPAAEPLEELQACISTLVDKHREAQQVLARLEKENQQLRGSLSP--GGEP-GSSS
--KVAASPQVAALEQDLGKLEEELRAVQATMSG--KSQEIGKLKQLLYQATEEVAELRAR
EAASMRQHEKTRGSLVAQ----AQAWGQELKALLEKYNMACREMGRLREAVAEERRRSGD
LAARAAEQERQAKEMRGRSEQFEKTAELLKEKVEHLIGACRDKEAKIKELLKKLEQLSEE
VLAVRGENACL-ALQLQDAQKNHEEIISTYRNHLLNAARGYMEQDVYSILLRILSMQEE-
----------

--------------------------------------------------------MKRF
FSCSSSQVA-------------------VERWNRRDQK

PF12796 // ENSGT00530000063369_3_Domain_1 (99, 204)

LLEAVQRGDVGRVAALASRKSA
RPTKLNSNGQSP---FH---LAASKGLTECLTILLANGADINSKNE-------DGSTALH
LATISCQPQCVKVLLQHGANEDA

ENSGT00530000063369_3_Linker_1_3 (204, 216)

V---D-AENRSP

PF12796 // ENSGT00530000063369_3_Domain_3 (216, 317)

LHWAA---SSGCASSVLLLCDHEAF
LDVLDN---------DGRTPLMIASLGGHAAICSQLLQRGARVNVTDKDDKSALILACEK
GSAEVAELLLSHGADAGAMDSMGHGALHYALCTQDKVLCQLLQQALNRRGQRGGQGLVQHPDLAS----QASPSEPHV-------------GSPPKSPCRAEPEEEQEEE--EEEDPC-SDEWRWKYEEEQRKVSQLEQELVQKTEEAKVQAAAYLGLENHIREQVHELGLLLSQEPGAPGG-QSSSLRPGGDGMEHGCP---LGLLAQRIQELRKRQQAAAV--APANLVLASKKAEDS---TTGEIQYEAPRRFPP-EEQEP-PQSPTCETIGKATGQQLTTNGG-------QALGPDHTDKPCGGQKERP-------------WAPGAEPTGTVAEPLGTI-A-MNQLLLQLREELA-AVWREK-D---AARGALSRRVLEGALGTPQAEAAAAAWEKMEARLEQVLVRLDRAKAGLQVKPQAAAQ---EPSEGAPKAEPATIT------KENEGGQKRAPG-APGEP----GGE-----QMR-GGGLAQGQLEKEVAALRLSNTNLLEELGELGQERRRLQGELQSLSQRLQRDFVPKPEAHVQLMQLRRSVGLLTDELALEKEATEKLRKRLASQTSGLQGLWDSLPPDLVGEGST-G--RAAAEPLEELRARLRALVQRHREGQKALARLEHENRQLRGPPGP-------AASS--KAPAPPEVAALEQDLGKLEEELRAVQATMSG--KSQEIGKLKQLLYQATEEVAELRAREAASLRQHEKTRGSLVAQ----AQAWGQELKALLEKYNAACREAGALREAVAEERRRSGELAARAAEQERRASEMRGRSQQFEETAERF

PF12796 // ENSGT00530000063369_3_Domain_5 (216, 317)

LHWAA---SSGCASSVLLLCDHEAFLDVLDN---------DGRTPLMIASLGGHAAICSQLLQRGARVNVTDKDDKSALILACEKGSAEVAELLLSHGADAGAMDSMGHGALHYALCTQDKVLCQLLQQALNRRGQRGGQGLVQH
PDLAS----QASPSEPHV-------------GSPPKSPCRAEPEEEQEEE--EEEDPC-S
DEWRWKYEEEQRKVSQLEQELVQKTEEAKVQAAAYLGLENHIREQVHELGLLLSQEPGAP
GG-QSSSLRPGGDGMEHGCP---LGLLAQRIQELRKRQQAAAV--APANLVLASKKAEDS
---TTGEIQYEAPRRFPP-EEQEP-PQSPTCETIGKATGQQLTTNGG-------QALGPD
HTDKPCGGQKERP-------------WAPGAEPTGTVAEPLGTI-A-MNQLLLQLREELA
-AVWREK-D---AARGALSRRVLEGALGTPQAEAAAAAWEKMEARLEQVLVRLDRAKAGL
QVKPQAAAQ---EPSEGAPKAEPATIT------KENEGGQKRAPG-APGEP----GGE--
---QMR-GGGLAQGQLEKEVAALRLSNTNLLEELGELGQERRRLQGELQSLSQRLQRDFV
PKPEAHVQLMQLRRSVGLLTDELALEKEATEKLRKRLASQTSGLQGLWDSLPPDLVGEGS
T-G--RAAAEPLEELRARLRALVQRHREGQKALARLEHENRQLRGPPGP-------AASS
--KAPAPPEVAALEQDLGKLEEELRAVQATMSG--KSQEIGKLKQLLYQATEEVAELRAR
EAASLRQHEKTRGSLVAQ----AQAWGQELKALLEKYNAACREAGALREAVAEERRRSGE
LAARAAEQERRASEMRGRSQQFEETAERFKDKVEHLIGACRDKEAKIKELLKKLEQLSEE
VLAVRGENAHL-ALQLQDSQKNHEEIISTYRNHLLNAAQGYMEQDVYNILLRILSIQEE-
----------

--------------------------------------------------------MKRI
FSCSSSQVA-------------------VERWNRRDQKLLEAVQQGDVGRVAALASRKSA
RPTKLDS

PF00023 // ENSGT00530000063369_3_Domain_1 (128, 165)

NGQSP---FH---LAASKGLTECLTILLANGADINSK

ENSGT00530000063369_3_Linker_1_2 (165, 174)

NE-------

PF00023 // ENSGT00530000063369_3_Domain_2 (174, 208)

DGDTALH
LATISCQPQCVKVLLQHGANEDAV---D-AENRSPLHWAA---SSGCASSVLLLCDHEAF
LDVLDN---------

PF00023 // ENSGT00530000063369_3_Domain_5 (256, 288)

DGRTPLMIASLGGHTAICSQLLQRGARVNVTD

ENSGT00530000063369_3_Linker_5_6 (288, 291)

KDD

PF00023 // ENSGT00530000063369_3_Domain_6 (291, 320)

KSALILACEK
GSAEVAELLLAHGADAGAVDRTGHDALHYALHTKDEALWRLLQQALNRRRRG-GQSLVQC
PDFAS----KASPLESQV-------------GSPPKSPWRAEPEEDREEE--EDANPC-S
EEWKWKYEEQQKKVSQLEQELVRKTEECKTQAAAYLGLENQIREQVRELGLLLCQEPAAP
GR-QDSSLRPGGDGMEQGCP---LDLLAKCIQELKKQQQAAAI----VNPTLASKKAEDS
---APGETQYEVHGRSQP-EEQGL-FQSPRSETTGKATGQHLTTNGG-------QTLDPD
HNEQLPTGQKENP-------------QVPGVETAGIAVETVGTA-A-MNQLLLQLREELA
-AVWREK-D---AARGAISRPILEGALGTSRAEAAAAAWEKMEARLERVLVRLDRAKTGL
QVKP---AQ---ESREGAPKAALGSIK------E-DEGKEKRSPG-VRGEPLGAPGRE--
---QTP-GGGLAKGHLEKEVSALRLSNSNLMEELGELGRERQRLQRELQSLSQRLQREFV
PKPEAQVQLQQLQRSVGLLTEELAVEKEATEKLRKRLASQSSSLRGLWDCLPLDLVGKGS
E-W--GTAAQPLEELQACIGALVDRHREAQQVLARLEEENQQLRGSLAP--RGEP-GASS
--KPPAPPQVAALEQDLGKLEEELRVVQATMSG--KSQEIGKLKQLLYQATEEVAELRAR
EAASLRQHEKTRGSLVAQ----SQAWGQELKALLEKYNTACQEMGRLREVVAEERRRNRD
LAAQAAEQERQAREMRGRSEQFEKTAELLKEKMEHLIGACRDKEAKIKELLKKLEQLSEE
VLAVRGENARL-ALQLQESQKNHEEIIAIYRNHLLNAAQGYVEQDVYNILLRILSTQEE-
----------

--------------------------------------------------------MKRI
FSCSSSQVA-------------------VERWNRRDQKLL

PF12796 // ENSGT00530000063369_3_Domain_1 (101, 202)

EAVQRGDVGRVAALASRKSA
RPTKLDSNGQSP---FH---LAASKGLTECLTLLLANGADINSKNE-------DGSTALH
LATISCQPQCVKVLLQHGANE

ENSGT00530000063369_3_Linker_1_3 (202, 211)

DAV---D-A

PF12796 // ENSGT00530000063369_3_Domain_3 (211, 287)

ENRSPLHWAA---SSGCASSVLLLCDHEAF
LDVLDN---------DGCTPLMIASLGGHTAICSQLLQRGARVNVTDKNDKSALILACEK
GSAEVAELLLSHGADAGAVDSTGHDALHYALHTQDKSLWRLLQQALNRRQRG-GQRLVQH
PDLAS----QASPSEPQA-------------GSPPKSPWRAEPEEEQEEE--EDEDPC-S
EEWRWKYEEEQRKVVQLEQELVQKTEECKTQAAACLRLENQIREQVQELGLLLSWEPRAS
GR-QGSSLRPGGDGMEQGCP---MDLLAERIQELKKQ-QQAAA---TVNPVLALKKAEDS
---APGEIQYEVHGRSQQ-EEQGP-PQSPESETIRKTTGQQLTTSGA-------QTFGHD
HADQLPAGQKESS-------------QVLGVEPGGTVAEPVGPA-A-MNQLLLQLREELA
-AVWREK-D---AARGALSRPVMEGALGTPRAEAAAAAWEKMEARLECVLARLERAKAGL
QVKPEVPSQ---ESREGALKAAPGSIR-------EDEEKEKRVPG-AHGEPLGAPGGE--
---KA--LGGLAKGQLEKEVSALRLSNSNLVEELGELGRERQRLQRELQSLSQRLQREFV
PKPEAQVQLQQLRQSVGLLTDELAVEKEATEKLRKLLAAQSSGLRGLWDCLPPDLVGKRS
A-Q--SKAAEPLEELRACITTLVDRHREAQQVLARLQEENRQLRGSLSP--CREP-GTSL
--KAPASPQVAALEQDLGKLEEELRAVQATMSG--KSQEIGKLKQLLYQATEEVAELRAR
EAASLRQHEKTRGSLVAQ----AQVWGQELKALLEKYNTACREMGRLREAVAEERRRSGD
LAAKAAEQERQASEMRGRSEQFEKTAELLKEKMEHLIGACRDKEAKIKELLKKLEQLSEE
VLAIRGENARL-ALQLQDSQKNNEEIISTYRNHLLNAARGYMEHEVYNILLRILSMQEE-
----------

--------------------------------------------------------MKRI
FSCSSSQVA-------------------VERWNRRDQKLLEAVHRGDVGRVAALASRKSA
RPTKLDS

PF00023 // ENSGT00530000063369_3_Domain_1 (128, 165)

NGQSP---FH---LAASKGLTECLTILLANGADINSK

ENSGT00530000063369_3_Linker_1_2 (165, 174)

NE-------

PF00023 // ENSGT00530000063369_3_Domain_2 (174, 208)

DGSTALH
LATISCQPQCVKVLLQHGANEDAV---D-AENRSPLHWAA---SSGCASSVLLLCDHEAF
LDVLDN---------

PF00023 // ENSGT00530000063369_3_Domain_5 (256, 288)

DGRTPLMIASLGGHAAICSQLLQRGARVNVTD

ENSGT00530000063369_3_Linker_5_6 (288, 291)

KND

PF00023 // ENSGT00530000063369_3_Domain_6 (291, 320)

KSALILACEK
GSAEVAELLLSHGADAGAVDSTGHDALHYALHTQDQALWRLLQQALNRRWRG-GQRLVQH
PDLAS----QASPSEPQA-------------GSPPKSSWRAEPEEEQEEK--EDEDPR-S
EEWRWKYEEERRKVVQLEQELVQKTEECKTQAAAYLGLENQIREQAQELGLLLSWEPRAS
GR-QGSSLRPGGDGMEQGCP---MDLLAESIQELKKQ-QQAAA---TVNPVLAPKKAEDS
---APGKIQYEVHGRSQP-EEQGP-PQSPASETIRKATGQQLTTNGA-------QTFGPD
HADQLPAGQKESS-------------QVLGVEPGGTVAEPVGPA-A-MNQLLLQLREELA
-AVWREK-D---AARGALSRPVMEGALGTPRAEAAAAAWEKMEARLERVLARLERAKAGL
QVKPEVPSQ---ESREGALKAAPGSIK-------EDEEKEKRVPG-ARGEPLGAPGGE--
---KA--LGGLAKGQLEKEMSVLRLSNSNLLEELGELGRERQRLQRELQSLSQRLQREFV
PKPEAQVQLQQLRQSVGLLTNELAMEKEATEKLRKLLASQSSGLRGLWDCLPADLVGKRS
A-Q--SKAAESLEELRACISTLVDRHQEAQQVLARLQEENQQLLGSLSP--WGEP-GTSL
--KAPASPQVAALEQDLGKLEEELRAVQATMSG--KSQEIGKLKQMLYQATEEVAELRAR
EAASLRQHEKTRGSLVAQ----AQAWGQELKALLEKYNTACREMGRLREAVAEERRRSGD
LAAQAAEQERQASEMRGRSEQFEKTAELLKEKMEHLIGACRDKEAKIKELLKKLEQLSEE
VLAIRGENARL-ALQLQDSQKNHEEIISTYRTHLLNAARGYMEHEVYHILLRILSMEEE-
----------

--------------------------------------------------------MKRI
FSCSSSQVA-------------------VERWNRRDQKLL

PF12796 // ENSGT00530000063369_3_Domain_1 (101, 202)

EAVQRGDVGRVAALASRKSA
RPTKLDSNGQSP---FH---LAASKGLTECLTLLLANGADINSKNE-------DGSTALH
LATISCQPQCVKVLLQHGANE

ENSGT00530000063369_3_Linker_1_3 (202, 211)

DAV---D-A

PF12796 // ENSGT00530000063369_3_Domain_3 (211, 287)

ENRSPLHWAA---SSGCASSVLLLCDHEAF
LDVLDN---------DGRTPLMIASLGGHTAICSQLLQRGARVNVTDKNDKSALILACEK
GSAEVAELLLSHGADAGAVDSTGHDALHYALHTQDKSLWRLLQQALNRRRRG-GQRLVQH
PDLAS----QASPSELQA-------------GSPPKSPWRAEPEDEQEEE--EDEDPC-S
EEWRWKYEEEQRKVVQLEQELVQKTEECKTQAAACLRLENQIREQVQELGLLLSWEPRAS
GR-QGSSLRPGGDGMEQGCP---MDLLAERIQELKKQ-QQAAA---TVNPVLALKEAEDS
---APGEVQYEVHGRSQQ-EEQGP-LQSPESETIRKATGQQLTTSGA-------QTFGPD
HADQLPAGQKESS-------------QVLGVEPAGTVAEPVGSA-A-MNQLLLQLREELA
-AVWREK-D---AARRALSRPVMEGALGTPRAEAAAAAWEKMEARLECVLARLERAKAGL
QVKPEVPSQ---ESREGALKAAPGSIK-------EDEEKEKSVPG-ARGEPLGAPGGE--
---KA--LGGLAKGQLEKEVSALRLSNSNLVEELGELGRERQRLQRELQSLSQRLQREFV
PKPEAQVQLQQLRQSVGLLTDELAVEKEATEKLRKLLAAQSSGLRGLWDCLPPDLVGKRS
A-Q--SKAAEPLEELRACITTLVDRHREAQQVLARLQEENRQLRGSLSP--CREP-GTSL
--KAPASPQVAALEQDLGKLEEELRAVQATMSG--KSQEIGKLKQLLYQATEEVAELRAR
EAASLRQHEKTRGSLVAQ----AQAWGQELKALLEKYNTACREMGRLREAVAEERRRSGD
LAAKAAEQERQASEMRGRSEQFEKTAELLKEKMEHLIGACRDKEAKIKELLKKLEQLSEE
VLAIRGENARL-ALQLQDSQKNKEEIISTYRNHLLNAARGYMEHEVYNILLRILSMQEE-
----------

--------------------------------------------------------MKRI
FSCSSSQVA-------------------VERWNRHDQKLLEAVQRGDVGRVAALASRKSA
RPTKLDS

PF00023 // ENSGT00530000063369_3_Domain_1 (128, 166)

NGQSP---FH---LAASKGLTECLTILLANGADINSKN

ENSGT00530000063369_3_Linker_1_2 (166, 174)

E-------

PF00023 // ENSGT00530000063369_3_Domain_2 (174, 210)

DGSTALH
LATISCQPQCVKVLLQHGANEDAV---D-

ENSGT00530000063369_3_Linker_2_3 (210, 211)

A

PF00023 // ENSGT00530000063369_3_Domain_3 (211, 246)

ENRSPLHWAA---SSGCASSVLLLCDHEAF
LDVLD

ENSGT00530000063369_3_Linker_3_5 (246, 256)

N---------

PF00023 // ENSGT00530000063369_3_Domain_5 (256, 288)

GGRTPLMIASLGGHAAICSQLLQRGARVNVTD

ENSGT00530000063369_3_Linker_5_6 (288, 289)

K

PF00023 // ENSGT00530000063369_3_Domain_6 (289, 321)

DDKSALILACEK
GSAEVAELLLSHGADVGAVDSTGHDALHYALRTQDKALWKLLQLAMNRRRQG-GQGLVQH
LDLAT----RVSPSEPQV-------------GSPPKSAWRAEPEEEQEEE--EDEDPC-S
EEWRWKYEEQQRKVSQLEQELVQKTEECKAQAAAYLGLENQIQEQVQELGLLLSQEPGTP
GG-QGSSLRPGGDGMEQGCP---VDLLAERIQELKKQQQVA-----TANPTLTPKKAQDS
---APGDIQYEAHGRSHP-EEQGP-P---RSETIGRATGQQVTISGG-------QALDLS
QTDQRCAGQKERP-------------QAPGAEPGGTVAEPVGPA-A-MHQLLLQLREELA
-AVWREK-D---AARGALSRPVLEGALGTPQAEAAAAAWEKMEARLEQVLVRLDKAKAGL
QVKPEAPAQ---EPRDGAPKATPGTIT------KEYEGKEKKAPG-ARGEPLGAPGVE--
---QAP-GGGLPKCQLEKEVSALRLSNSNLLGELGELGRERQRLQGELQSLNKRLQREFV
PKPEAQVQLLQLQRSVGLLTDELAVEKEATEKLRQRLASQSSGLRGLWNCLPPDIVGKEG
A-Q--STAADPLGELQAYIRTLVDRHREAQQVLALLEEENQQLRKTPAP--RGEP-ETSS
--KVPASPQVAALEQDLGKLEEELRAVQATMSG--KSQEIGKLKQLLYQATEEVAELRAR
EAASLRQHEKTRGSLVAQ----AQAWGQELKALLEKYNTACREMARLREAVAEERRRNGD
LIARAAEQERQAGEMRGRSEQFEKTAELLKEKMEHLIGACRDKEAKVSKRGSRNRNQCGD
GLSTERRNSVLKGIKCGDF-HKPHWLISNFLSVLSCHSQGYMEQDVYNILLRILSMQE--
----------

--------------------------------------------------------MKRI
FSCSSSQVA-------------------VERWNRRDQKLL

PF12796 // ENSGT00530000063369_3_Domain_1 (101, 202)

EAVQRGDVGRVAALASRKSA
RPTKLDSNGQSP---FH---LAASKGLTECLTILLANGADINSKNE-------DGSTALH
LATISCQPQCVKVLLQHGANE

ENSGT00530000063369_3_Linker_1_3 (202, 211)

DAV---D-A

PF12796 // ENSGT00530000063369_3_Domain_3 (211, 287)

ENRSPLHWAA---SSGCASSVLLLCDHEAF
LDVLDN---------DGRTPLMIASLGGHAAICSQLLQRGARVNVTDKDDKSALILACEK
GSAEVAELLLGHGADAGAVDRTGHDALHYALHTQDKALWRLLRQALNRRRRG-GQRLVQY
SDLAS----QASPSEPQA-------------GSPPKSPWRAEPEEEQEEE--EDEDPC-S
EEWKWKYEEEQRKVSQLEQELVRKTEECKTQAAAYLGLENHVREQVQELGLLLSQEPTAP
QR-GGSSLRPGGDGMEQGCP---LALLVEHIQELKKQQQVAAT----VTPTLAPSKAEDS
---APGEVQYEVHARFQP-QEQGP-PQSPRSETIGKNTEEQLTTNGG-------QTLGPD
HTNLLPAGQKERP-------------QAPGVEPAGTVVEPVGIA-A-MNQLLLQLREELA
-AVWREK-D---AARGALSRPILEGALGTPRAEAAAAAWEKMEARLERVLVRLDQAKAGL
QVKP---AQ---ESREGAPKAAPGSIR------EH--EEEKRSPG-ARGEPLGAPGEE--
---QAP-GGGLAKGQLEKEVSALRLSNSNLLEELGELGRERQRLQRELQSLSQRLQREFV
PKPEAQVQLQQLRQSVGLLTDELAMEKEAAEKLRKRLASQSSGLRGLWDCLPPDLVGKGS
A-R--STVAEPLQELQACVSTLVDRHREAERVLARLEEENQQLRGSLAP--GGEP-GVSS
--RVPASPQVAALEQDLGKLEEELRVVQATMSG--KSQEIGKLKQLLYQATEEVAELRAR
EAASLRQHEKTRGSLVAQ----AQAWGQELKALLEKYNTACQEMGRLREGLAEERRRNGE
LAARAAEQEQQARDMRGRSEQFEKTAELLKEKMEHLIGACRDKEAKIKELLKKLEQLSEE
VLAVRGENARL-VLQLQDYQKNHEEIISTYRNHLLNAARGYMEQDVYDILLRILSIQEE-
----------

--------------------------------------------PPPRPPPSV-------
-------------------------VPQLERWNRQDQKLLEAVERGDVGRVAALASRKTA
RPTKLDV

PF00023 // ENSGT00530000063369_3_Domain_1 (128, 165)

HGQSP---FH---LAASKGLTECLTVLLANGAEINTKNE-------DGQTLLH
LLQ----------HFSHGANEDAV---D-GENRSPLHWAA---SSGCASSVLLLCDHEAF
LDVLDN---------

PF00023 // ENSGT00530000063369_3_Domain_5 (256, 288)

DGRTPLMIASLGGHSAICSQLLQRGARVNVTD

ENSGT00530000063369_3_Linker_5_6 (288, 292)

KEDK

PF00023 // ENSGT00530000063369_3_Domain_6 (292, 320)

SALILACEK
GSAEVAELLLSHGADVGAVDRLGRNALHYALRTDDKAMQRLLRQALNRRRRGGETPRAAL
TP-----------S----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------

--------------------------------------------------------MKRF
FSCSSSQVASSQPDKHCQRTRGCLPRDRVERWNRHDQKLL

PF12796 // ENSGT00530000063369_3_Domain_1 (101, 202)

EAVQRGDVGRVAALASRKSA
RPTKLDSHGQSP---FH---LAASKGLTECLSILLANGADINSMNE-------DGSTALH
LATISCQPQCVKVLLQHGANEDAV---D-RENRTPLHWAA---SSGCASSVLLLCDHEAF
LDVLDN---------DGRTPLMIASLGGHAAICSQLLQRGARVNVLDK

PF12796 // ENSGT00530000063369_3_Domain_6 (289, 342)

DNKSALILACEK
GSAEVAELLLSHGADAGAVDREGHDALHYALRTRDKALWRLLRQALNRRQRG-GQRLVQH
PDLAS----QASPSEPHV-------------SSLPKSPWRAEPEEEQEED--EDEDPC-S
EEWRCKYEEEQKKVSQLKQELVQKTEECKAQAVAYVGLENQIREQVQELGLLLSQDPRAP
EG-QGCRLRPVGDGMEQGCP---LELLAEHIQELKKQQQSAAIVNEKAKK------VKE-
--SAPGEIQHGVDGTSQP-QEQGL-LQSPGSEATRKATEQQLTSGGQTL--------LS-
----SHTSQKERL-------------QASGVEPVGTA--------A-MNQLLLQLREELA
-AVWREK-D---AARGALSRSVLEGALGTPQAEAAAAAWEKMEARLEQVLVRLDRAKAGL
QAKPEVPDQ---ESKAGVPKTALGCIK--------EHDEEKRAPG-TRGEPLGAPGEQ--
---L-P-GGGLAKGQLE-EVSALRLSNNNLLEELGELGRERQRLQGELQSLSQRLQREFV
PKPEAQVQVQQLQKSVGQLTDELAMEKEATEKLRKRLASQSSGLQELWHCLPPDVVGKAS
A-R--NTAAEPLEELHTCISMLVDRHREAQQVLAQLEQENQSLRASLSL--GGEP-GTFA
--KFPASPQVAALEQDLGRLEEELRAVQATMSG--KSQEITKLKQLLYQATEEVAELRAR
EAASLRQHEKTRGSLVAQ----AQAWGQELKDVLEKYNTACREMGRLREAAAEERRRSED
LATLAAKQERQASELRGRSEQFEKTAELLKGKTEHLIEACRDKEVKIKELLKKLEQLSEE
VLSVRGENTRL-ALQLQDSQKNKEEIITTYRNHLLNAAQGYMEQDVYNILLRILSMQEE-
----------

--------------------------------------------------------MKRI
FSCSSSQVA-------------------VERWNRRDQKLLEAVQRGDVGRVAALASRKSA
RPTKLDA

PF00023 // ENSGT00530000063369_3_Domain_1 (128, 165)

NGQSP---FH---LAASKGLTECLTILLANGADINSK

ENSGT00530000063369_3_Linker_1_2 (165, 174)

NE-------

PF00023 // ENSGT00530000063369_3_Domain_2 (174, 208)

DGSTALH
LATISCQPQCVKVLLQHGANEDAV---D-AENRSPLHWAA---SSGCASSVLLLCDHEAF
LDVLDN---------

PF00023 // ENSGT00530000063369_3_Domain_5 (256, 288)

DGRTPLMIASLGGHAAICSQLLQRGARVNVTD

ENSGT00530000063369_3_Linker_5_6 (288, 291)

KDD

PF00023 // ENSGT00530000063369_3_Domain_6 (291, 320)

KSALILACEK
GSAEVAELLLSHGADAGAVDSTGHDALHYALRTQDKALWKLLRQALNRRRRG-GQKLVQH
PDGIS----QASPSEPQV-------------GSPPKSPWRAEPEEEQEEE--EDEGLC-L
EDWRCKYEEEQRKVSQLEQELVQKTEECKAQAAAYLGLENQIREQVQQLGLLLAPELGAP
EG-QGSGVRPGGDGMEQGCP---LDSLAECVQKLKKQQQTATS----ANSTFTPKRGEES
---APGEIQDEVHGRSQS-EKQGL-SQSPGAETSRKITEQTLGPGGQTAH--GGQILGPD
VTDQLHA----MP-------------AAPAQAPAGATAGPTSTA-A-MTQLLLQLREELA
-AVWREK-D---AARGALSRPILEGGLGTPRAEAAAAAWEKMEARLEQVLVRLDRANAGL
QVKPGVPAQ---ESRQGAPKAAPRSSR------KN--EEEKRAPG-ARGEPLGAPGEE--
---LSPGGAGLAKAQLEKEVSALRLSNSNLLEELGELGRERQRLQGELKSLSQRLQHEFV
PKPEAQVQLQQLRRSVGLLTDELALEKEATEKLRKRLASQSSGLRGLWDCLPPDLVGKGS
A-G--GMAAEPLQELQACISALVDRHKEAQQVLARLEKENQQLRGSLSP--GGEP-DASS
--KAPAPPQVAALEQDLGKLEEELRAVQATMSG--KSQEIGKLKQLLYQATEEVAELRAR
EAASLRQHEKTRGSLVGQ----AQAWGQELKVLLEKYNTACREMGQLREAVAEERRRSGD
LAARAAEQERQASEMRGRSEQFEKTAELLKEKTEHLIGACRDKEAKIKELLKKLEQLSEE
VLAVRGEKARL-ALQLQDSQKNHEEIISAYRNHLLNAAQGYMEQDVYNILLRILSMQEA-
----------

--------------------------------------------------------MKRI
FSCSSSQVAXXXXXXXXXXXXXXXXX-------------------XXX---XXXXXXXXX
XXXXXXXXXX

PF00023 // ENSGT00530000063369_3_Domain_1 (131, 166)

XXXXXFH---LAASKGLTECLTILLTNGADINSKN

ENSGT00530000063369_3_Linker_1_2 (166, 174)

E-------

PF00023 // ENSGT00530000063369_3_Domain_2 (174, 210)

DGSTALH
LATISCQPQCVKVLLQHGANEDAV---D-

ENSGT00530000063369_3_Linker_2_3 (210, 211)

A

PF00023 // ENSGT00530000063369_3_Domain_3 (211, 246)

ENRSPLHWAA---SSGCASSVLLLCDHEAF
LDVLDNXXXXXXXXXXXXX---------XXXXXXXXXXXXXXXXXXXX

PF00023 // ENSGT00530000063369_3_Domain_6 (289, 321)

XXXSALILACEK
GSAEVAGLLLSHGADVGTVDSTGHDALHYALNTKDKALWRLLRQALNRRRRG-GQSLVQH
PDLVS----QASPSGSQI-------------GSPPKSPWRAEPEEEQEEE--EDEDPC-S
EEWRWKYEEEQRKVSQLEQELVRKTEECKAQAAAYLGLENQIREQVQELGLLLSRQSGTP
EE-EGSSLRPGGDGMEQGCP---LYLLAEHIQELKQRQAVAT-----VKPTSDPKKAEDL
---APGETQYEVHGMPQP-EELAP-LQSPRCEITAKATGQPPTISREQ-------TLSXX
XXXXXXXXXXXXX-------------XXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXX
XXXXXXX-X---XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXX--XXXXXXXXXXXXXXX--X---XXXXXXXXXXXX-XXXXXXXXXXXX--
---XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--X---XXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
X----X-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXX-XXXX
--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXXXXXXXTEDM---LAP
MHRATSMRHEKRGSLVAQ----AQAWGQELKVLLEKYNTACREMSRLREAVAEERRRSGD
LATRAAEQERQAREMRGRSEQFEKTAELLKDKMEHLIGACRDKEAKIKELLKKLEQLSEE
VLAVRGENARL-ALQLQDSQKNHEEIISTYRNHLLNAARGYLEQDVYNILQRILRIQEE-
----------

--------------------------------------------------------MKRI
FSCSSSQVA-------------------VERWNRRDQKLLEAVQRGDVGRVAALASRKSA
RPTKLDS

PF00023 // ENSGT00530000063369_3_Domain_1 (128, 165)

NGQSP---FH---LAASKGLTECLTILLASGADINSK

ENSGT00530000063369_3_Linker_1_2 (165, 174)

NE-------

PF00023 // ENSGT00530000063369_3_Domain_2 (174, 208)

DGSTALH
LATISCQPQCVKVLLQHGANEDAV---D-AENRSPLHWAA---SSGCASSVLLLCDHEAF
LDVLDN---------

PF00023 // ENSGT00530000063369_3_Domain_5 (256, 288)

DGRTPLMIASLGGHAAICSQLLQRGARVNVTD

ENSGT00530000063369_3_Linker_5_6 (288, 291)

KND

PF00023 // ENSGT00530000063369_3_Domain_6 (291, 320)

KSALILACEK
GSAEVAELLLSHGADAGAVDSTGHDALHYALRTQDRPLWRLLRQALNRQGRG-GQGPVQH
LNPAS----QTSPSEPQV-------------GAPPKSPWRAEPEEEQEEE--EDEDPC-S
EEWKWKYEEEKRKVSQLEQELLRKTEECKAQATAYLGLENQIQEQVRELGLLLSQEPRAP
EN-QGSSLRHGGDGMEQGCA---LNLLAKHIQELKKHQQATAA--AAANPVLASKKAEDS
--V-PGEIQYEAQGRSQP-EEQEP-PQSPKSETVGKTTGQQLTNSDG-------QALRLD
QTDQLFAGRKERP-------------QAPGSEPTSTVAEPAGTA-A-MNQLLLQLREELA
-AVWREK-D---AARGALSRSVLEGALGTPRAEAAAAAWEKMEARLEQVLVRLDRAKAGL
QMKPKAPAQ---EPREEAPKALPGTIT------QEDEEKEKRVPG-ARGEPLGAPGGD--
---QMP-GGGQARGQLEKEVSALRLSNSNLLEELGELGRERQRLQGELQSLSQRLQQEFV
PRPEAQDQLQQLRRSVGLLTDELALEKQATEKLRKRLASQNRGLQGLWDCLPPDLVGQGS
A-R--SAAAEPLEDLQACISALVARHREAQQGLARLEEENQQLRGSPSR--LGEP-GVSS
--EASASPQVAALEQDLGKLEEELRAVQATMSG--KSQEIWKLKQLLYQATEEVEELRAR
EAASLRQHEKTRGSLVAQ----AQAWGQELKALLEKYNTACREMGRLREAAAEERRRSGD
LAARAAEHERQASEMRGRSQQFEKTAELLKEKVEHLIGACRDKEAKIKELLKKLEQLSEE
VLAVRGDNARL-ALQLQDSQKNHEEIISTYRKHLLNAAQGYMEQDVYNILLRILSIQE--
----------

--------------------------------------------------------MKRF
FSCSSSQVA-------------------VERWNRRDQKLLEAVQRGDVGRVAALASRKSA
RPTKLNS

PF00023 // ENSGT00530000063369_3_Domain_1 (128, 165)

NGQSP---FH---LAASKGLTECLTILLANGADINSK

ENSGT00530000063369_3_Linker_1_2 (165, 174)

NE-------

PF00023 // ENSGT00530000063369_3_Domain_2 (174, 208)

DGSTALH
LATISCQPQCVKVLLQHGANEDAV---D-AENRSPLHWAA---SSGCASSVLLLCDHEAF
LDVLDN---------

PF00023 // ENSGT00530000063369_3_Domain_5 (256, 288)

DGRTPLMIASLGGHAAICSQLLQRGARVNVTD

ENSGT00530000063369_3_Linker_5_6 (288, 291)

KDD

PF00023 // ENSGT00530000063369_3_Domain_6 (291, 318)

KSALILACEK
GSAEVAELLLSHGADAGAMDGTGHDALHYALRTQDKVLCRLLRQALNRRGQRGGQGLVQH
PDLAS----QASSSEPHM-------------GSPPKSPWRAEPEEEQEEEE-EEEDPY-P
DEWRWKYEEEQRKVSQLEQELVQKTEEAKTQAAAYLGLENQIREQVQELGLLLAQEPGAP
GG-QGSSLRPGGDGMEQGCP---LGLLAKRIQELRKQQQAAAA--VATKPALAPKKAEDL
---ASGGIQHEAQGRLQP-EEQEP-PQSLRCETAGKATGQQLSANGG-------QALGRD
GTDEPSAGQKEKP-------------QAPGADPIGTAAEPMGPA-A-MNQLLVQLREEVA
-AVWREK-D---AARGALSRPVLEGALGTPQVEAAAAAWEKMEARLEQVLVRLDRAKAGL
QGKPQAPAQ---EPREGASKAGLVIIT------KENEGKEKKAPG-ARGEPLGAPGGE--
---RLP-GGCPAKGQLEKEVAALRRSNSNLLEELGELGQERQRLQGELQSLSQRLQRDFV
PKPEAQVQLQQLRRSVGLLTDELAIEKEATEKLRKRLASQSSGLQGLWNYLPPDLVGKGS
A-G--RTAGEPLEELQACISTLVEQHREAQKGLARLEEENQQLRGALAP--CGEP-GTLS
--EAPAPPQVAALEQDLGKLEEELRAVQATMSG--KSQEIGKLKQLLYQATEEVAELRAR
EAASLRQHEKTRGSLVAQ----AQAWGQELKALLEKYNTACREMARLRQAVAEERRRSGD
LATRAAEQERQAGELRARSQQFEQTAEQFKDKVDHLIGACRDKEAKIKELLKKLEQLSEE
VLAVRGENARL-ALQLQDSQKNHDEIISTYRNHLLNAAQGYMEQDVYNILLRILSIQEE-
----------

--------------------------------------------------------MKRI
FSCSSSQVA-------------------VERWNRRDQKLL

PF12796 // ENSGT00530000063369_3_Domain_1 (101, 202)

EAVQRGDVGRVAALASRKSA
RPTKLDSNGQSP---FH---LAASKGLTECLTLLLANGADINSKNE-------DGSTALH
LATISCQPQCVKVLLQHGANE

ENSGT00530000063369_3_Linker_1_3 (202, 211)

DAV---D-A

PF12796 // ENSGT00530000063369_3_Domain_3 (211, 287)

ENRSPLHWAA---SSGCASSVLLLCDHEAF
LDVLDN---------DGRTPLMIASLGGHTAICSQLLQRGARVNVTDKNDKSALILACEK
GSAEVAELLLSHGADAGAVDSTGHDALHYALHTQDKSLWRLLQQALNRRQRG-GQRLVQH
PDLAS----QASPSEPQA-------------GSPPKSPWRAEPEEEQEEE--EDEDPC-S
EEWRWKYEEEQRKVVQLEQELVQKTEECKTQAAACLRLENQIREQVQELGLLLSWEPRAS
GR-QGSSLRPGGDGMEQGCP---MDLLAERIQELKKQ-QQAAA---TVNPVLALKKAEDS
---APGEIQYEVHGRSQQ-EEQGP-LQSPESETIRKTTGQQLTTSGT-------QTFGHD
HADQLPAGQKESS-------------QVLGVEPGGTVAEPVGPA-A-MNQLLLQLREELA
-AVWREK-D---AARGALSRPVMEGALGTPRAEAAAAAWEKMEARLECVLARLERAKAGL
QVKPEVPSQ---ESREGALKAAPGSIK-------EDEGKEKRVPG-ARGEPLGAPGGE--
---KV--LGGLAKGQLEKEVSALRLSNSNLVEELGELGRERQRLQRELQSLSQRLQREFV
PKPEAQVQLQQLRQSVGLLTDELAVEKEATEKLRKLLAAQSSGLRGLWDCLPPDLVGKRS
A-Q--SKAAEPLEELRACITTLVDRHREAQQVLARLQEENRQLRGSLSP--CREP-GTSL
--KAPASPQVAALEQDLGKLEEELRAVQATMSG--KSQEIGKLKQLLYQATEEVAELRAR
EAASLRQHEKTRGSLVAQ----AQAWGQELKALLEKYNTACREMGRLREAVAEERRRSGD
LAAKAAEQERQASEMRGRSEQFEKTAELLKEKMEHLIGACRDKEAKIKELLKKLEQLSEE
VLAIRGENARL-ALQLQDSQKNNEEIISTYRNHLLNAARGYMEHEVYNILLRILSMQEE-
----------

--------------------------------------------------------MKRI
FSCSSSQVS-------------------VERWNRRDQKLLEAVQRGDVGRVAALASRKSA
QPTKLDSNGQSPXXXXX---XXXXXXXXXXX----------XXXXXXXXXXXX

PF00023 // ENSGT00530000063369_3_Domain_2 (174, 210)

XXSSALH
LATISCQPQCVKVLLQXXXXXXAV---D-

ENSGT00530000063369_3_Linker_2_3 (210, 211)

A

PF00023 // ENSGT00530000063369_3_Domain_3 (211, 246)

DNRSPLHWAA---SSGCASSVLLLCDHEAF
LDVLD

ENSGT00530000063369_3_Linker_3_5 (246, 256)

N---------

PF00023 // ENSGT00530000063369_3_Domain_5 (256, 288)

DGRTPLMIASLGGHAAICSQLLQRGARVNVLDKDDKSALILACEK
GSAEVAELLLSHGADAGAVDS

PF00023 // ENSGT00530000063369_3_Domain_7 (322, 355)

SGHDALHYALHMQDKTLCRLLRQAMNRRRRR-GKGLVQH
PDLAS----QTSPSEPQV-------------GSPPKSPWRAEPEEEQGQE--EDEDPC-S
DEWRWKCEEERRRVSQLEQELVRKTEECKARAAAYLGLENQIREQVQELGLLLAQEPGAL
GR-HGSELRPGGDGMEQGCP---LDLLAERIQELKKQQQVAA-----ANPTLTPKKVQDS
---TPGETPHKDHGKSQP-EEVGP-PQSPRSETVGKATGQQVTTSAG-------QRLDPK
HSDQLCADQ-ERP-------------PAPGAEPAGTVMEPVGSL-A-MNQLLLQLREELA
-AVWREK-D---AARGALSGPVLAGALGTPRAEAAAAAWEKMEARLEQVLVRLDRAKAGL
QVKPETPSK---EPREGIPQATPGSVT------KGEEEREKTAPE-AQGEPLGAPGGG--
---QAP------QGQLEKEVSALRLSNSNLLEELGQLGRERQRLQGELQTLSQRLHREFA
PKPEAQVQLQQLRGSVGRLTEELATEKEATEKLRKRLASQSSGLRGLWECLPPDLAGPGA
P-------GEPLEALQPCISTLVDRHREAQKVLARLEAENQQLRGTQAQ--SGGA-E-TP
--TVPAGPQVAALEQDLGKLEVELRAVQATMGG--KSQEIGKLKQLLYQATEEVAELRAR
EAASLRQHEKTRASLVAQ----AQAWGQELKALLEKYNAACRETARLREAVAEERRRGRE
LAARAAEQERQSSQVRGRSQQFEKTTELLKEKMEHLFEACRDKEAKXXXXXXXXXXXXXX
XXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXGYMEQDVYSILLHILSMQAE-
----------

--------------------------------------------------------MKRI
FSCSSSQVA-------------------VERWNRRDQKLLEAVQRGDVGRVAALASRKSA
RPTKLDS

PF00023 // ENSGT00530000063369_3_Domain_1 (128, 165)

NGQSP---FH---LAASKGLTECLTLLLANGADINSK

ENSGT00530000063369_3_Linker_1_2 (165, 174)

NE-------

PF00023 // ENSGT00530000063369_3_Domain_2 (174, 208)

DGSTALH
LATISCQPQCVKVLLQHGANEDAV---D-AENRSPLHWAA---SSGCASSVLLLCDHEAF
LDVLDN---------

PF00023 // ENSGT00530000063369_3_Domain_5 (256, 288)

DGRTPLMIASLGGHTAICSQLLQRGARVNVTD

ENSGT00530000063369_3_Linker_5_6 (288, 291)

KND

PF00023 // ENSGT00530000063369_3_Domain_6 (291, 320)

KSALILACEK
GSAEVAELLLSHGADAGAVDSTGHDALHYALHTQDKSLWRLLQQALNRRRRG-DQRLVQH
PDLAS----QASPSEPQA-------------DSPPKRPWRAEPEEEQEEE--EDEDPC-S
EEWRWKYEEEQRKVVQLEQELVQKTEECKTQAAACLRLENQIQEQVQELGLLLSWEPRAS
GR-QGSSLRPGGDGMEQGCP---MDLLAERIQELKKQ-QQAAA---TVNPVSALKKAEDS
---APGEIQYEVHGRSQQ-EEQGP-PQSPESETIRKTTGQQLTTSGA-------QTFGPD
DADQLPAGQKESS-------------QVLGVEPGGTVAEPVGPA-A-MNQLLLQLREELA
-AVWREK-D---AARGALSRPVMEGALGTPRAEAAAAAWEKMEARLECVLARLERAKAGL
QVKPEVPSQ---ESREGALKAAPGSIK-------EDEEKEKRVPG-ARGEPLGAPGGE--
---KA--LGGLAKGQLE-EVSALRLSNSNLVEELGELGRERQRLQRELQSLSQRLQREFV
PKPEAQVQLQQLRQSVGLLTDELAVEKEATEKLRKLLAAQSSGLRGLWDCLPPDLVGKRS
A-Q--SKAAEPLEELRACITTLVDRHREAQQVLARLQEENRQLRGSLSP--CREP-GTSL
--KAPASPQVAALEQDLGKLEEELRAVQATMSG--KSQEIGKLKQLLYQATEEVAELRAR
EAASLRQHEKTRGSLVAQ----AQAWGQELKALLEKYNTACREMGRLREAVAEERRRSGD
LAAKAAEQERQASEMRGRSEQFEKTAELLKEKMEHLIGACRDKEGKIKELLKKLEQLSEE
VLAIRGENARL-ALQLQDSQKNNEEIISTYRNHLLNAARGYMEHEVYNILLRILSMQEE-
----------

--------------------------------------------------------MKKM
FSCSTSQVA-------------------VESWNKQDQKLFEAVEKGDVGRVSVLASRKTA
RPTKLNAL

PF00023 // ENSGT00530000063369_3_Domain_1 (129, 166)

GQSA---FH---LAASKGLTECLTLLLSHGAEVNQTN

ENSGT00530000063369_3_Linker_1_2 (166, 174)

D-------

PF00023 // ENSGT00530000063369_3_Domain_2 (174, 208)

DGSTALH
LATIACQPQCVKVLLQHGANED---CVDG-ENRTPLHWAA---SSGCASSVLLLCDHEAF
LDVTDN---------

PF00023 // ENSGT00530000063369_3_Domain_5 (256, 288)

NGRTPLMIAAMGNHPAICCQLLQRGASGNLTDKDQKTALILACES
ISVESAELLVSSGVDLSVVDRMGHDALHYALQSQSRPLRRLLRSALKKRKRRGEDGAYLD
LGAE------MSLPPPQF-------------GSAKK------PASASEEGDWDEEEDLDA
EEWRCRCEDEQMKVLQLEEQLATKAKECDALAEGRKVMKERIWDQVQEISQLLWS-----
-G-QMKSRRYSRDATEEDYY---LNLLSEQVQELKKRKQEAGSEVATA---LEEKE--N-
--ATKRVVEIEGHLENMR-DEEGM-CQSPGGEGRGPRRNAELEGDNQRLR--G--LLAKQ
QGESQKAGKQEV----------------DQREPRSALCTELGPFLSWMRKACARAQEEKA
-AVLAENEDLKREAEEALRGKFHLEAVPSEAVRQSMASWEKMVMGLEHALAKMGEANSNL
LEKARPL-QE--AISAPHSKQEPGVVEQ-------------LTPR-LRDNS------E--
---ETKGRARRRSSDLEKEVSDLRENNGSLLNELAQLGMEREKLQEELQRLQQHPEKEGS
PRAEAQDVVEELRQRVAALSQELSAEKEETKKLRLRLETQKREMVVLRDSFLKQMMGEAN
KVQSQSLGACILEELHWKLDNLVKKHNEALQLVSEIEEESQMLESDQTPAVQLGG--E--
-LVLEPWRWVNELERDLWELKEELEAAQATLGS--EGHDMTKLKQLLDRLPVKVAELCSE
EEEALRMHEKAWSSLALQ----TQALEEELRALQEKHEEVREKSAQREEVLASERQKNKD
LLDKVAELEKEAREPRRKSEQLQRTIKDLNKKVEELSRTCQDKEGKIKKLLKETEKLSAE
ILTLRSESARL-QLQLEVKEKNHQEIVTIYRTHLLNAAQGFMDEDVHSMLLRILRAKEE-
----------

--------------------------------------------------------MKRF
FSCSSSQVA-------------------VERWNRRDQKLLEAVQRGDVGRVAALASRKSS
RPTKLDA

PF00023 // ENSGT00530000063369_3_Domain_1 (128, 166)

NGQSP---FH---LAASKGLTECLTILLANGADINSKN

ENSGT00530000063369_3_Linker_1_2 (166, 174)

E-------

PF00023 // ENSGT00530000063369_3_Domain_2 (174, 210)

DGSTALH
LATISCQPQCVKVLLQHGANEDAV---D-

ENSGT00530000063369_3_Linker_2_3 (210, 211)

A

PF00023 // ENSGT00530000063369_3_Domain_3 (211, 246)

ENRSPLHWAA---SSGCASSVLLLCDHEAF
LDVLD

ENSGT00530000063369_3_Linker_3_5 (246, 256)

N---------

PF00023 // ENSGT00530000063369_3_Domain_5 (256, 288)

DGRTPLMIASLGGHAAICSQLLQRGARVNVTD

ENSGT00530000063369_3_Linker_5_6 (288, 289)

K

PF00023 // ENSGT00530000063369_3_Domain_6 (289, 321)

DDKSALILACEK
GSAEVAELLLSHGADAGAVDSAGHDALYYGLRTQDKALWKLLQQALSWRR--GGQGLVQH
PDAAS----KASPSEPPV-------------GSQPKSPRGAEPGAEQEKE---REEVC-S
EEWRWKYEEEQKKVSQLEQELVGKTEESKAQAAAYLGLANQIREQVQELGRLLFREPRAP
GG-QSPGIRPGGDGMEQGCP---LDLLAEGIRELKKQQQAVAA--AAANPVLASKKTEDS
---SPREMCYEAHARSQP-E-QGP-PQGPVSEIPGEAAGQHQTTVGG-------QALGPE
RAAQPHAGRKERR-------------KAPGAERAGTAAGAAGTA-A-MNQLLLQLREELA
-AVWREK-D---AALGALSRPVLEGVLGKSRAEATAAAWEKMEARLEQVLLKLDRAKAGL
RATPATPAQ---ESREGAPKAGSETIP------EEDGEKETGAPG-TQRESPGAPGRP--
---QTP-GGGLAKGMLEKEVSALRLSNSNLLEELGELGRERQRLQGELQSLSQRLQREFV
PRPVAQVQLQQLRWSVGLLTDELAVEKEATEKLRRHLASQSSGLRGLWDCLPPDLVGKAG
A-R--GPGPEPLQELQACISALVARHREAQQMLARLEEENQRLRGASAP--HPEP-GPSS
--QATAPPEVAALEQDLGQLEEELRAVQASMRG--KSQEIGKLKQLLYQATEEVAELRAR
EAASLRQHERARSSLAAQ----AQAWSQELKALLEKYNSACCEVGRLQEAVADERCRSGD
LAARATEQERQASEMRGRSEQFEKTVGLLREKMEHLLGACQDKEAKIKELLKKVEQLSEE
VLAVRGENARL-ASQLRDSQKNHEEIISTYRNHLLSAAQGYMEQDVYNILLRILSRQEK-
----------

--------------------------------------------------------MKRI
FSCSSTQVA-------------------VERWNRHDQKLLEAVHRGDVG

PF12796 // ENSGT00530000063369_3_Domain_1 (110, 202)

RVAALASRKSA
RPTKLDSNGQSP---FH---LAASKGLTECLTILLANGADINSKNE-------DGSTALH
LATISCQPQCVKVLLQHGANE

ENSGT00530000063369_3_Linker_1_3 (202, 211)

DAV---D-A

PF12796 // ENSGT00530000063369_3_Domain_3 (211, 287)

ENRSPLHWAA---SSGCASSVLLLCDHEAF
LDVLDN---------DGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEK
GSAEVAELLLSHGADAGAVDSTGHDALHYALHTQDKALWRLLQQALNRRRRG-GQRLVQH
PDLAS----QASPSEPQA-------------GSPPKSSWRAEPEEEQEEK--EDEDPC-S
EEWRRKYEEERRKVVQLEQELVQKTEECKTQAAAYLDLENQIREQAKELGVLLSWEPRAS
GR-QGSSLRPGGDGMEQGCP---KDLLAESTQEPKKQ-QQAAA---TVNPVLAPKKAEDS
---APGKIQYEVHGRSQP-EEQGP-PQGPASETIRKATGQQLTTNGA-------QTFGPD
HADQLPAGQKESS-------------QVLGVEPGGTVAEPVGPA-A-MNQLLLQLREELA
-AVWREK-D---AARGALSRPVMEGALGTPRAEAAAAAWEKMEARLERVLARLERAKAGL
QVKPEVPSQ---ESREGALKAAPGSIK-------QDEEKEKRVPG-ARGEPLGAPGGE--
---KA--LGGLAKGQLEKEMSVLRLSNSNLLEELGELGRERQRLQRELQSLSQRLQREFV
PKPEAQVQLQQLRQSVGLLTNELAMEKEATEKLRKLLASQSSGLRGLWDCLPADLVGKRS
A-Q--SKAAESLEELRACISTLVDRHREAQQVLARLQEENQQLRGSLSP--CREP-GTSL
--KAPASPQVAALEQDLGKLEEELRAVQATMSG--KSQEIGKLKQLLYQATEEVAELRAR
EAASLRQHEKTRGSLVAQ----AQAWGQELKVLLEKYNTACREMGRLREAVAEERRRSGD
LAAQAAEKERQASEMRGRSEQFEKTAELLKEKMEHLIGACRDKEAKIKELLKKLEQLSEE
VLAIRGENARL-ALQLQDSQKNHEEIISTYRNHLLNAARGYMEHEVYNILLQILSMEEE-
----------

------------------------------------------------------------
------------------------------------------------------------
-------MGPPT----------------LPLALFLFPGSTA-----------------

PF12796 // ENSGT00530000063369_3_Domain_3 (179, 287)

LH
LATISCQPQCVKILLQHGANEDAV---D-AENRSPLHWAA---SSGCASSVLLLCDHEAF
LDVLDN---------DGRTPLMIASLGGHAAICSQLLQRGARVNVTDKDDKSALILACEK
GSAEVAELLLSHGADAGAVDSRGHDALHYALCTQDKTLWRLLQQALNRRRRG-GQRLVQH
PDLAS----QASSSEPHV-------------GSPLKSPWRAEPEEEQKEE--EDEDPC-S
KEWKWKYEEEQKKVSQLEQDLVRKTEECKAQAAAFLGLESQIREQVQELGLLLSQEPRAP
RG-HGSRLRPGGDGMEQGCP---LDLLAEHIQELKKQQQAAAIVNQEAKRV------E-E
N-SAAGEIQHEVHGKSPP-EEQGP-PQSPRSEATRKSTEQQLTGGP--------HTLVPD
HTGQQPADQKARP-------------QASGVEATDAVAEPVDTA-A-MNHLLLQLREELA
-AVWRDK-D---AARGALSRPVLEGALGTPRAEAAAAAWEKMEARLERVLVRLDRAKAGL
QGKPEVPGQ---ESRAGAPKAAPGCIK--------EHGEEELAPG-ARGEPLGAPGEQ--
---F-P-GGGLPKGQLEKEVSALRLSNNNLLEELRELGCERQRLQGELQSLSQRLRGEFV
PKLEAQVQLHQLQRSVGLLTEELAMEKEATEKLRKRLASQSSGLRGLWDCLPPDLVGTGR
A-R--SAEAEPLAELRACITALADRQREAQRALAGLEEENRRLRASLAL--GGEP-AAFS
--KAPASPQVAALEQDLGKLEEELRAVQAAMSG--KSQEMAKLKQLLYQATEEVAELRAQ
EAASLRQHEKTR-LLVAQ----AQAWGQELKDVLEKYNAACREMGRLREAAAEERRRSDD
LAARAAEQERRASELRGRSEEFEKTAEGLKEKTERLMEACRDKKAKIKELLKKLEQLSEE
VLSVRGENARL-ALELQDSQKSNEEIITTYRNHLLSAAQGYMEQDVYNVLLRILSMQEE-
----------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------HGANEDAV---D-AENRSPLHWAA---SSGCASSVLLLCDHEAF
LDVLDN---------DGRTPLMIASLGGHAAICSQLLQRGARVNVTDK

PF12796 // ENSGT00530000063369_3_Domain_6 (289, 342)

DDKSALILACEK
GSAEVAELLLSHGADAGAVDTLGHNALHYALRTQDKELWRLLQQALNRRRRG-GHGLVQH
PDHAS----QASPPEPQV-------------GSPPKSSWRAEPGEEEEG------ARC-S
EEWKRKYEEEQKKVSDLEQELERKTDECEAQAAAFSGLESQIREQVQELGRLLLQEPGAP
GR-QGPGLRPGGDGMEQGCP---LNLLAERIQELKRQQKAAAT----VNPTVVPGRAEEL
---TPAETQYGVHRASQP-ER--GPPQSPRSETTGKATGQQLSTSGG-------QTLGLD
NTDQVVVGQKERS-------------PDPGIEQAGTVGEPGGVA-A-LNQLLLQLREELA
-AVWREK-D---AARGALSRPVLEGALGTPRAEAAAAAWEKMEARLERVLVRLDRAKAGL
QVKPEVPAQ---GSRQGAPKAIPGCTK---------EHQEKRVPG-ARGEPQGAPGGE--
---QAS-VGGLAKGHLEREVSALRLSNSNLLEELGELGRERQRLQGELQSLTQRLQREFV
PKPEAQVQLQQLQRSVGLLADELAAEKEAAEKLRRRLASQSSGLQGLWNCLPPDLVGKGG
A-Q--STAAEPLEELQTCISTLVARHLEAQQALARLEEENQQLRRSLAP--HGEP-EASL
--KATASPQVAALEQDLGKLEEELRAVQATMSG--KSQEISKLKQLLYQATEEVAELRAR
EAASLRQHEKTRGSLVAQ----AQAWGQELKAVLEKYNTACQEMARLRDAAAEERRRSED
LAARAAEQERQAGEMRGRSEQFEKTAELLKEKTDHLIGACRDKEAKIKELLKKLEQLSEE
VLEVRGENTHL-ALQLQDSQKNHEEIISAYRNHLLNAAQGYMEQDVYNILLRILSMQE--
----------

--------------------------------------------------------MKRI
FSCSSSQVA-------------------VERWHRRDQKLLEAVXXXXXXXXXXXXXXXXX
X---XXXXXX

PF00023 // ENSGT00530000063369_3_Domain_1 (131, 166)

XXXXXFH---LAAFKGLTECLSILLANGADINSKN

ENSGT00530000063369_3_Linker_1_2 (166, 174)

E-------

PF00023 // ENSGT00530000063369_3_Domain_2 (174, 210)

DGNTALH
LATISCQPQCVKVLLQHGANEDAV---D-

ENSGT00530000063369_3_Linker_2_3 (210, 211)

A

PF00023 // ENSGT00530000063369_3_Domain_3 (211, 246)

ENRTPLHWAA---ASGCASSVLLLCDHEAF
LDVLD

ENSGT00530000063369_3_Linker_3_5 (246, 256)

N---------

PF00023 // ENSGT00530000063369_3_Domain_5 (256, 288)

DGRTPLMIASLGGYAAICSQLLQRGARVNVTD

ENSGT00530000063369_3_Linker_5_6 (288, 289)

K

PF00023 // ENSGT00530000063369_3_Domain_6 (289, 321)

GNKSALILACEK
GSAEVAELLLSHGADVWVVDSLGHDALDYALHTQEEALWRLLRQAMRWRQRGXXXXXXXX
XX-----XXXATSLKPQV-------------GCPPKSPWKAEPEEVQEEE--EDADLY-S
EEWRQKYEEEQKRVSQLEQELVQKTEECKAQAAAYLGLEKQIRVQVQELGLLLSQETGTP
RE-QGSSLRPGGDGSEQGCP---LDLLAEHIQELKKQQQVAT-----ANPALTPKKTQAS
---VPGDIQYEAHGRSQS-EQQ--PPQSPRSETMRKATARQVTTSGK-------QAVDCN
QSDLLRAGPKERP-------------QAPGAEPVGIVAETVGPA-A-MNLLLLQLREELA
-AVWQEK-D---AARGALSRSVLEGALGTARAEAAAAAWEKMEARLEQVLVRLDRAKAGL
QVKLQAPAQE--PRDAAYPKANSGTVT------KEDEGKEKKVPG-VRGEPLGAPGGE--
---QAL-GGGLPKGQLEKEVSALRLSNSNLLEELGELARERQRLQGELQSLSQRLQREFV
PKPEAQIQLLQLQRSVGLLKDELATEKKATEKLQKRLASQSNGLQGLWNCLPPELVDKER
D-Q--SAAAEPLEELQACISTLVERHREAQQVLARLKEENQRLQETLAL--RGEPE----
TSKVSASPQVAALEQDLGKLEEELRAVQATMSG--KSQEIGKLKQLLYQATEEVAELRAR
EAASLRQHEKTRGSLVAQAQAQAQAWGQELKALLEKYDTACREMARLRESVADEHRKSGD
LAARVAEQERQAGAMRGCAEQFEKTAEVLKGKVEHLILVRRDKEAKVKELLKKLEQLTEE
VLSVRAENVRL-AAELQSSRKNHEEIISTYRNHLLNAAQGYMEQSAYDILLQILSMQEE-
----------

--------------------------------------------------------MKRI
FSCSSSQVA-------------------VEKWNRRDQKLL

PF12796 // ENSGT00530000063369_3_Domain_1 (101, 202)

EAVQRGDVGRVAALASRKSA
RPTKLDSNGQSP---FH---LAASKGLTECLTILLANGADINSRNE-------DGSTALH
LATISCQPQCVKVLLQHGANE

ENSGT00530000063369_3_Linker_1_3 (202, 211)

DAV---D-A

PF12796 // ENSGT00530000063369_3_Domain_3 (211, 287)

ENRSPLHWAA---SSGCASSVLLLCDHEAF
LDVLDN---------DGRTPLMIASLGGHAAICSQLLQRGARVNVTDKDDKSALILACEK
GSAEVAELLLSHGADAGAVDSLGHNALHYALRTQDKELWRLLQQALNRRRRG-GHGLVQH
PDHAS----QASPPEPQV-------------GSPPKSSWRPEPEEEE------EEE-R-G
SEWKRKYEEEQRKVSQLEQELVRKTEECKAQAAAFLGLENQIREQVQELGHLLLQEPGAA
GR-QGPGLRPGGDGMEQGCP---LNLLAERIQELKRQQKAAAT----VNPTVAPRGAEEL
--A-PAEIQYEVHRKSQP-E-QGP-PQSPRSEAVEKATGQRLNTSGG-------QNLGLE
DTDQVCAAQKERS-------------PAPGIEQAGPVGEPVGIA-A-VNQLLLQLREELA
-AVWREK-D---AARGALSRPVLEGALGTPRAEAAAAAWEKMEARLERVLVRLDRAKAGL
QVKPEVFAQ---GAREGAPKAVPGCTK------E---HEEKRAPG-ARGEPLGAPGGE--
---QAPGGGGQAKGHLEKEVSALRLSNSNLLEELGELGRERQRLQGELQSLTQRLQREFV
PKPEAQVQLQQLRRSVGLLTEELAMEKEATEKLRKRLASQSSGLQGLWNCLPPDLVGKGS
A-R--STAAEPLEELQTCISILVDRHLETQRALARLEEENQQLRGSLSP--CGEL-EASL
--KATASPQVAALEQDLGKLEEELRAVQATMSG--KSQEICKLKQLLYQATEEVAELRAR
EAASLRQHEKTRGSLVAQ----AQAWGQELKVVLEKYNTACREMNRLRDAAAEERRRSED
LAARAAEQERQAGEMRGRSEQFEKTAELLKEKTDHLIGACRDKEAKIKELLKKLEQLSEE
VLEVRGENTHL-ALQLQDSQKSHEETISTYRNHLLNAARGYMEQDVYNILLRILSMQE--
----------

------------------------------------------------------------
----------------------------VERWNRRDQKLLEAVQRGDVGRVAALASRKSA
RPTKLDSHGQSP---GV---ERGEL---------------VG------------------
----LCQV-------------------------PGSTWIL---IN--------------P
FPQ

PF12796 // ENSGT00530000063369_3_Domain_3 (244, 318)

SVQ---------DGRTPLMIASLGGHAAICSQLLQRGARVNVLDKDNKSALILACEK
GSAEVAELLLSHGADAGAVDREDHDALHYALRTQDKALWRLLRQALNRRQRG-GKSYFVISRFSS-----------IT-------------KELKKSPWRAEPEEEQEED--EDEDPC-SEEWRCKYEEEQKKVSQLKQELVQKTEECKAQAVAYVGLENQIREQVQELGLLLSQDPRAPEG-QGCRLRPVGDA--------------EHIQELKKQQQSAAIVNQKAKK------VEE---SAPGEIQHGVDGMSQP-QEQGL-LQSPGSEATRKATEQQLTSGGQTL--------LS-----SHTSQKERL-------------RASGVEPVGTA--------A-MNQLLLQLREELA-AVWREK-D---AARGALSRSVLEGALGTPRAEAAAAAWEKMEARLEQVLVRLDRAKAGLQAKPEVPDQ---ESRAGVPKTALGCIK--------EHDEEKRAPG-TRGEPLGAPGEQ-----L-P-GGGLAKGQLE-EVSALRLSNNNLLEELGELGRERQRLQGELQSLSQRLQREFVPKPEAQVQVQQLQKSVGQLTDELAMEKEATEKLRKRLASQSSGLQELWHCLPPDVVGKASA-R--NTAAEPLEELHTCISMLVDRHREAQQVLAQLEQENQSLRASLSL--GGEP-GTFA--KFPASPQVAALEQDLGRLEEELRAVQATMSG--KSQEITKLKQLLYQATEEVAELRAREAASLRQHEKTRGSLVAQ----AQAWGQELKDVLEKYNTACREMGRLREAAAEERRRSEDLATLAAKQERQASELRGRSEQFEKTAELLKEKTEHLIEACRDKEVKFHFLFFI---

PF12796 // ENSGT00530000063369_3_Domain_5 (244, 318)

SVQ---------DGRTPLMIASLGGHAAICSQLLQRGARVNVLDKDNKSALILACEKGSAEVAELLLSHGADAGAVDREDHDALHYALRTQDKALWRLLRQALNRRQRG-GKSYFVI
SRFSS-----------IT-------------KELKKSPWRAEPEEEQEED--EDEDPC-S
EEWRCKYEEEQKKVSQLKQELVQKTEECKAQAVAYVGLENQIREQVQELGLLLSQDPRAP
EG-QGCRLRPVGDA--------------EHIQELKKQQQSAAIVNQKAKK------VEE-
--SAPGEIQHGVDGMSQP-QEQGL-LQSPGSEATRKATEQQLTSGGQTL--------LS-
----SHTSQKERL-------------RASGVEPVGTA--------A-MNQLLLQLREELA
-AVWREK-D---AARGALSRSVLEGALGTPRAEAAAAAWEKMEARLEQVLVRLDRAKAGL
QAKPEVPDQ---ESRAGVPKTALGCIK--------EHDEEKRAPG-TRGEPLGAPGEQ--
---L-P-GGGLAKGQLE-EVSALRLSNNNLLEELGELGRERQRLQGELQSLSQRLQREFV
PKPEAQVQVQQLQKSVGQLTDELAMEKEATEKLRKRLASQSSGLQELWHCLPPDVVGKAS
A-R--NTAAEPLEELHTCISMLVDRHREAQQVLAQLEQENQSLRASLSL--GGEP-GTFA
--KFPASPQVAALEQDLGRLEEELRAVQATMSG--KSQEITKLKQLLYQATEEVAELRAR
EAASLRQHEKTRGSLVAQ----AQAWGQELKDVLEKYNTACREMGRLREAAAEERRRSED
LATLAAKQERQASELRGRSEQFEKTAELLKEKTEHLIEACRDKEVKFHFLFFI-------
------------------------------SCCLSCRVQGYMEQDVYNILLRILSMQEE-
----------

--------------------------------------------------------LKSG
FSC-------------------------FSLWNRRDQKLLEAVQRGDVGRVAALASRKSA
RPTKLDSSGQSPPLPLSPWKLTSQQGVL-----------------------DEDLRTKLH
VASF-------CGSLQH

PF12796 // ENSGT00530000063369_3_Domain_3 (198, 287)

GANEDAV---D-MENRSPLHWAA---SSGCASSVLLLCDHEAF
LDVLDN---------DGRTPLMIASLGGHAAICSQLLQRGARVNVKDKDDKSALILACEK
GSAEVAELLLSHGADAGALDSLGHNALYYALQTQDKALCGLLRQALNRRRRG-GQKLVQH
PDLAS----QASPSELQV-------------GFPPTSPWKAEPEKEQEEE--EEEDQC-S
AEWRLKYEEEQKKVSQLERELVLKTEECKAQATAYLGLENQIREQVQELGRLLVQEPGAP
EE-QGSSFRPGGDGMEQGCP---LDLLVEHIQELKRQQQRTT------------------
----PADIQRGVHGTSRE-EE-GP-S-----QIPRKDTGQPLTSHGR-------QTLGPD
HKDQLCASQQERP-------------QALGVEPAGPVEEVAAGKAA-MNQLLLQLREELA
-AVWRDK-D---TARGALSRPILEGALGTPRAEAAAAAWEKMEARLERVLVRLDQAKAGL
QGKTEIEGQG--QARPEG---------------QETPKEKPRVPW-ARGEPQGAPGKE--
---PSP---GGAKGLLEKEVSALRRSNSHLLEELGELGRERQRLQGELQALGLRLQREFV
PRPEAQVQLQQLRRSVGLLADELAAEKEAAEKLRQRLASHSGGVRALWDCLPADLAGRRG
E-------AEALEELQGCVRALVDRLRQAQGAVARLEEENQRLRGSTSP--RGDP-----
----AASPQVAALERDLGALEAELRAVQATMGA--KSQEMAKLKQLLYQATEEVAELRAR
EAASLRRHEQAREHR---------AW----------------------------------
---------------------------RLDDRTERLAAAARDKEAKIKELLKKLEQLSEE
VLAVRGENARL-TLQLQDSQKNHEEIISTYRNHLLNAAQGYMEQNVYNILLRILSVQE--
----------

------------------------------------------------------------
----------------------------VEKWNRRDQKLLEAVQRGDVNRVSALTRKKTA
RPTKLDS

PF00023 // ENSGT00530000063369_3_Domain_1 (128, 165)

HGQSP---FH---LAASKGLTECLSILLTNGAEINSK

ENSGT00530000063369_3_Linker_1_2 (165, 174)

NE-------

PF00023 // ENSGT00530000063369_3_Domain_2 (174, 208)

DGDTALH
LATISCQPQCVKVLLQHGANEDAV---D-GENRSPLHWAA---SSGCASSVLLLCDHEAF
LDVLDN---------

PF00023 // ENSGT00530000063369_3_Domain_5 (256, 288)

DGRTPLMIASLGGHAAICAQLLQRGARVNVTD

ENSGT00530000063369_3_Linker_5_6 (288, 292)

KEDK

PF00023 // ENSGT00530000063369_3_Domain_6 (292, 320)

SALILACEK
GSAEVAELLLSHGADVGAVDCMGHDALYYALRTQDKELWRLLRQALNRRQRG-GQGLAQH
PDLSSQVKSKAFPFEPHIP-------DNLTPGSPPNCPIRAEPEEEDDKE-EGGEELCSP
QEWRRKYEAERKKVSQLEQELVKKAEECKSQATACRGLESSVREQVQELGLLLAKESRDP
GG-QGVSPRPGGDGMEHSCV---LDLLVEQVQELKRQHQAAGG-----------------
-------LQHESQGKARP-EG-----QSPVEEVPGKAKGEQLADVPGHG-----------
SGDPALALREERR-------------RPPGAEPAGMV--------A-LGQLLLQLREELT
-AVWRDK-D---AARGVLGRPAGKGVWGTSQAEAAAAAWEKMEARLEQPECPEGA---SL
QAQAASPT----------------SP------AREGQAQEERAQE-ARGEPLGAPEG---
---------AGPKGQLEKEVSALRLSNSNLLEELGQLGRERQRLQGELQALGQRLQREYM
PRPEAQGQLQQLRSSVGLLAEELAAEKEATEQLRRRLEAQSTGLQGLRDRLPPDLSPQGS
A-------SDPLEELQACVGALVARYDQAQRELASLERENQRLKGSCQD--TGAP-----
----QAVPQVAALEQDLGKLEEELRAVQATMGG--KSQEIGKLKQLLYQATEEVAELWAR
EAVSLKQQEKSRASLVAQ----AQSWGQELKAVLEKYNNACKETGQLRDAVAEERRRSRE
LAARATEQERQAREMRGRSEQFEKAGEVLKEKMDQLIAACREKEAKIKELLKKLEQMSAE
VLAVRGENTHL-VLQLQDSQKNHQEIISTYRNHLLNAARGYMEQDVYKILLRILKMQE--
----------

--------------------------------------------------------MKRI
FSCSSSQVA-------------------VERWNRRDQKLLEAVQRGDVGRVAALASRKSA
RPTKLDS

PF00023 // ENSGT00530000063369_3_Domain_1 (128, 163)

NGQSP---FH---LAASKGLTECLTLLLANGADINKIGNPMGVWDEDVNTKLH
AAS-------LCGHLQHGANEDAV---D-AENRSPLHWAA---SSGCASSVLLLCDHEAF
LDVLDN---------DGRTPLMIASLGGHTAICSQLLQRGARVNVTDK

PF12796 // ENSGT00530000063369_3_Domain_6 (289, 342)

NDKSALILACEK
GSAEVAELLLSHGADAGAVDSTGHDALHYALHTQDKSLWRLLQQALNRRQRG-GQRLVQH
PDLAS----QASPSEPQA-------------GSPPKSPWRAEPEEEQEEE--EDEDPC-S
EEWRWKYEEEQRKVVQLEQELVQKTEECKTQAAACLRLENQIREQVQELGLLLSWEPRAS
GK-QGSSLRPGGDGMEQGCP---MDLLAERIQELKKQQQAAAT----VNPVLALKKAEDS
---APGEIQYEVHGRSQQ-EEQGP-PQSPESETIRKTTGQQLTTSGT-------QTFGHD
HADQLPAGQKESS-------------QVLGVEPGGTVAEPVGPA-A-MNQLLLQLREELA
-AVWREK-D---AARGALSRPVMEGALGTPRAEAAAAAWEKMEARLECVLARLERAKAGL
QVKPEVPSQ---ESREGALKAAPGSIK------E-DEGKEKRVPG-ARGEPLGAPGGE--
---KA--LGGLAKGQLEKEVSALRLSNSNLVEELGELGRERQRLQRELQSLSQRLQREFV
PKPEAQVQLQQLRQSVGLLTDELAVEKEATEKLRKLLAAQSSGLRGLWDCLPPDLVGKRS
A-Q--SKAAEPLEELRACITTLVDRHREAQQVLARLQEENRQLRGSLSP--CREP-GTSL
--KAPASPQVAALEQDLGKLEEELRAVQATMSG--KSQEIGKLKQLLYQATEEVAELRAR
EAASLRQHEKTRGSLVAQ----AQAWGQELKALLEKYNTACREMGRLREAVAEERRRSGD
LAAKAAEQERQASEMRGRSEQFEKTAELLKEKMEHLIGACRDKEAKIKELLKKLEQLSEE
VLAIRGENARL-ALQLQDSQKNNEEIISTYRNHLLNAARGYMEHEVYNILLRILSMQEE-
----------

--------------------------------------------------------MQRI
FSCSSSQVA-------------------VERWNRRDQKLLEAVQRGDVGRVAALASRKSA
RPTKLDS

PF00023 // ENSGT00530000063369_3_Domain_1 (128, 165)

NGQSP---FH---LAASKGLTECLTILLANGADINSK

ENSGT00530000063369_3_Linker_1_2 (165, 174)

NE-------

PF00023 // ENSGT00530000063369_3_Domain_2 (174, 208)

DGNTALH
LATISCQPQCVKVLLQHGANEDAV---D-AENRSPLHWAGMGSSSGCASSVLLLCDHEAF
LDVLDK---------

PF00023 // ENSGT00530000063369_3_Domain_5 (256, 288)

DGRTPLMIASLGGHTAICSQLLQRGARVNVTD

ENSGT00530000063369_3_Linker_5_6 (288, 291)

KDD

PF00023 // ENSGT00530000063369_3_Domain_6 (291, 320)

KSALILACEK
GSAEVAELLLSHGADAGAVDSMGHDALHYALRTQDKVLWRLLRQALNRRRQG-GQGLVQH
PDLAS----QAFPSEPQV-------------GSPPKSPWRAEAEEEQEEE-EDEEDPC-S
DEWRWKYEEEQRKVSQLEQKLIRKTEECKAQAAAYLGLENQIREQVQELGFLLSQEPGAP
GE-QGTSLRPGGDGMEQGCP---LDLLAKHIQELKKQQRATAA--ATANPVLASKKAEDS
---APGEIQYEAHVKSQT-EEQGP-PQSPRSDTIGKTTGQQLTTNGG-------QSLGPD
HTDQQHADRKERP-------------QTPRAEPIGTEAEPVGTA-A-MNQLLLQLREELA
-AVWREK-D---AARGALSRPVLEGALGTPRAEAAAAAWEKMEARLERVLVRLDWAKAGL
QMKPEAPAQ---EPRKGAPKAGLGTIA------KEDEGREKRVLG-AQGQPLWVPGGE--
---QMP-GGGLAKGQLEKEVSALRLSNSNLLEELGELGQERQRLQRELQSLSQRLQREFV
PKPEAQVQLQQLRRSVGLLTDELAMEKEATEKLRKRLASQSSGLQGLWDCLPPDLVGKGS
A-R--GTVAEPLEELQACISTLVDRHCEAQQVLARLEEENQQLRGSSAT--RAEP-GSSS
--KDPASPQVAALEQDLGKLEEELRAVQATMSG--KSQEIGKLKQLLYQATEEVAELRAR
EAASLRQHEKTRGSLVAQ----AQAWGQELKALLEKYNTACREMGRLRQAVAEERRKSGD
LAARAAEQERQASEMRGRSDQFEKTAELLKEKMEHLIGACQDKEAKIKELLKKLEQLSEE
VLAVRGENARL-AQQLQESQKNHEEIISTYRNHLLNAAQGYMEQDVYHILLRILSMQED-
----------

--------------------------------------------------------MKRI
FSCSSSQVA-------------------VERWNRHDQKLL

PF12796 // ENSGT00530000063369_3_Domain_1 (101, 202)

EAVQRGDVGRVAALASRKSA
RPTKLDSNGQSP---FH---LAASKGLTECLTLLLANGADINSKNE-------DGSTALH
LATISCQPQCVKVLLQHGANE

ENSGT00530000063369_3_Linker_1_3 (202, 211)

DAV---D-A

PF12796 // ENSGT00530000063369_3_Domain_3 (211, 287)

ENRSPLHWAA---SSGCASSVLLLCDHEAF
LDVLDN---------DGRTPLMIASLGGHTAICSQLLQRGARVNVTDKNDKSALILACEK
GSAEVAELLLSHGADAGAVDSTGHDALHYALHTQDKSLWRLLQQALNRRRRG-GQRLVQH
PDLAS----QASPSEPQA-------------GSPPKSPWRAEPEEEQEEE--EDEDPC-S
EEWRWKYEEEQRKVVQLEQELVQKTEECKTQAAACLRLENQIREQVQELGLLLSWEPRAS
GR-QASSLQPGGDGMEQGCP---MDLLAERIQELKKKQQQAAA---TVNPVLALKKAEDS
---APREIQYEVHGRSQQ-EEQGP-PQSPESETIRKATGQQLTTSGA-------QTFGPD
HADQLPAGQKGSS-------------QVLGVEPGGTVAEPVGPA-A-MNQLLLQLREELA
-AVWREK-D---AARGALSRPVMEGALGTPRAEAAAAAWEKMEARLERVLARLERAKAGL
QVKPEVPYQ---ESREGALKAAPGSIK-------EDEEKEKRVPG-ARGEPPGAPGGE--
---KA--LGGLAKGRLEKEVSALRLSNSNLVEELGELGRERQRLQRELQSLSQRLQREFV
PKPEAQVQLQQLRQSVGLLTDELAVEKEATEKLRKLLAAQSSGLRGLWDCLPPDLVGKRS
A-Q--SKAAEPLEELRACITTLVDRHREAQQVLARLQEENRQLRGSLSP--CREP-GTSL
--KAPASPQVAALEQDLGKLEEELRAVQATMSG--KSQEIGKLKQLLYQATEEVAELRAR
EAASLRQHEKTRGSLVAQ----AQAWGQELKALLEKYNTACREMGRLREAVAEERRRSGD
LAAKAAEQERQASEMRGRSEQFEKTAELLKEKMEHLIGACRDKEAKIKELLKKLEQLSEE
VLAIRGENARL-ALQLQDSQKNNEEIISTYRNHLLNAARGYMEHEVYNILLRILSMQEE-
----------

--------------------------------------------------------MKRI
FSCSSSQVA-------------------VERWNRRDQKLLEAVHRGDVG

PF12796 // ENSGT00530000063369_3_Domain_1 (110, 202)

RVAALASRKSA
RPTKLDSNGQSP---FH---LAASKGLTECLTILLANGADINSKNE-------DGSTALH
LATISCQPQCVKVLLQHGANEDAV---D-AENRSPLHWAA---SSGCASSVLLLCDHEAF
LDVLDN---------DGRTPLMIASLGGHAAICSQLLQRGARVNVTDK

PF12796 // ENSGT00530000063369_3_Domain_6 (289, 342)

NDKSALILACEK
GSAEVAELLLSHGADAGAVDSTGHDALHYALHTQDKSLWRLLQQALNRRRRG-GQRLVQH
PDLAS----QASPSEPQA-------------GSPPR----AEPEEEQEEK--EDEDPC-S
EEWRPKYEEEQRKVVQLEQELVQKTEECKAQAAAYLGLENQIREQVQALGLLLSWEPRAS
GR-QGSSLRPGGDGMEQGCP---MDLLAERIQELKKQ-QQVAA---TVNLVLAPKKAEDS
---APGKIQYEVHGRSQP-EEQGP-PQSPASETIRKATGQQLTTNGA-------QTFGPD
HADQLPAGQKESS-------------QVLGVEPGGTVAEPVGPA-A-MNQLLLQLREELA
-AVWREK-D---AARGALSRPDMEGALGTPRAEAAAAAWEKMEARLERVLARLERAKAGL
QVKPEVPSQ---ESREGALKASPGSIK-------EDEEKEKRVPG-AGGEPLGTPGGE--
---KA--LGGLAKVQLEKEMSVLRLSNSNLLEELGELGRERQRLQRELQSLSQRLQREFV
PKPEAQVQLQQLRQSVGLLTNELTMEKEATEKLRKLLASQSSGLRGLWDCLPPDLVGKRS
A-Q--SKAAESLEELRACITTLVDRHREAQQVLARLQEENQQLRGSLSQ--CGEP-GTSL
--KVPASPQVAALEQDLGKLEEELRAVQATMSG--KSQEIGKLKQLLYQATEEVAELRAR
EAASLRQHEKTRGSLVAQ----AQAWGQELKALLEKYNTACREMGRLREAVAEERRRSGD
LAAQAAEQERQASEMRGRSEQFEKTAELLKEKMEHLIGACRDKEAKIKELLKKLEQLSEE
VLAIRGENARL-ALQLQDSQKNHEEIISTYRNHLLNAAQGYMEHEVYNILLRILSMEEE-
----------

--------------------------------------------------------MKRI
FSCSSSQVA-------------------VERWSRRDQKLL

PF12796 // ENSGT00530000063369_3_Domain_1 (101, 202)

EAVQRGDVGRVAALASRKSA
RPTKLDSNGQSP---FH---LAASKGLTECLTILLANGADVNSKNE-------DGSTALH
LATISCQPQCVKVLLQHGANE

ENSGT00530000063369_3_Linker_1_3 (202, 211)

DAV---D-A

PF12796 // ENSGT00530000063369_3_Domain_3 (211, 287)

ENRSPLHWAA---SSGCASSVLLLCDHEAF
LDVLDN---------GGRTPLMIASLGGHAAICSQLLHRGARVNVTDKDDKSALILACEK
GSAEVAELLLSHGADAGAVDSMGHDALHYALHTQDKSLWRLLQQALNRRR--GGQGLVQH
PHLAS----QASPLKPQA-------------GSSCKTPWRAEPEEEQEEE--EDEAPC-S
EEWRWKFEEEKRKVSQLEQELVQKIEECKTQAAAYLGLENQIQEQAQELGLLLSWEPRAS
GG-QGSSLRPGGDGMEQGHP---LDLLAERIQELKKQQQAAAT----VNSVLAPKKAEDS
---APGEIQFEVHGRSQP-E-QEL-PQSSGSETIRKATGQQLTTGVG-------QTLGPD
HADQMPAGQ-ERP-------------QVLGVEPGDTVAEPAGPA-A-MNQLVLQLREELA
-AVWREK-D---AARAALSRPVMEGARGTSRAEAAAAAWEKMEARLEQVLARLDRAKAGL
QVKPEIPAQ---ESRDGAPNAAAGSAK------KG--EEEKSVPG-ARGEPLGAPGEE--
---QA--LGGLAKGQLEKEVSALRLSNSNLLEELGELGRERQRLQRELQSLNQRLQREFV
PKPEAQDQLQQLQQSVGLLTDELAVEKEATEELRRRLASQSSSLRGLWDCLPADLAGKRS
A-R--SEAAEPPEELRACISTLADQHREAQQVLARLREENLQLRGSLSP--RGEP-GTSF
--KVAASPQVAALEQDLGKLEEELRAVQATMSG--KSQEIGKLKQLLYQATEEVAELRAR
EAASLRQHEKTRGSLVAQ----AQAWGRELKALLEKYNAACREVGRLREAVAEERRRSGD
LAARAAEQERQASEMRGRSEQFEKTAELLKEKMERLTGACRDKEAKIKELLKKLEQLSEE
VLAIRGENARL-ALQLQDSQKNHEEIISTYRSHLLNAARGCMEQNVYNILLGILSMQEE-
----------

--------------------------------------------------------MKRI
FSCSSSQVA-------------------VERWNRRDQK

PF00023 // ENSGT00530000063369_3_Domain_0 (99, 127)

LLEAVQRGDVGCVAALLSRKSA
RPTKLD

ENSGT00530000063369_3_Linker_0_1 (127, 128)

S

PF00023 // ENSGT00530000063369_3_Domain_1 (128, 166)

NCQSP---FH---LAASKGLTECLTVLLANGADINSKN

ENSGT00530000063369_3_Linker_1_2 (166, 174)

E-------

PF00023 // ENSGT00530000063369_3_Domain_2 (174, 210)

DGSTALH
SATISCQPQCVKVLLQHGANEDAV---D-

ENSGT00530000063369_3_Linker_2_3 (210, 211)

V

PF00023 // ENSGT00530000063369_3_Domain_3 (211, 246)

ENRTPLHWAA---FSGCASSVLLLCDHEAF
LDVLD

ENSGT00530000063369_3_Linker_3_5 (246, 256)

N---------

PF00023 // ENSGT00530000063369_3_Domain_5 (256, 288)

DGRTPLMIASLGGHAAICSQLLQRGARVNVTD

ENSGT00530000063369_3_Linker_5_6 (288, 289)

K

PF00023 // ENSGT00530000063369_3_Domain_6 (289, 321)

NDKSALILACEK
RSTEVAELLLSYGADAGAVDSTGHDALHYAVCTQDKMLWRLLRQALNRQGRG-GQELVQH
PDLSS----QASPSEPQV-------------GSPPKSPWRAEPEEEQEEE--EDEDPC-S
EEWKWKYEEEQRKVSQLEQELLRNTEERKAQSAAYLSLESQIQEQVRELGLLLSQEPGTP
GD-LRSSLRPGGDGMEQGCT---LDLLAKCIQELKKQQQAAAA--AAAKPVLASKKAEDS
---AGGVIQYDAHGRSQP-EQ--EPPHSPRSETIGRSTGQQLTANGG-------QALGPD
HTDQLHAGQKPRP-------------QAPGAEPTGTVAEPVHTA-A-MNQLLLQLREELA
-AVWREK-D---AARGALSRPDLEGAVGTSRAEAAAAAWEKMEARLEQVLVRLDRAKAGL
QMKPEAPAQ---EPREGSPKAGPGAIT------KEGEGKEEGTPG-AWGEPLGMPGGE--
---QMP-GGRLAEGQLEKEVSALRLSDSNLLQELGELGQERQWLQGELPSLSQRLQRECV
PKPEVQVQLQQLQWSMGLLTDELALEKEATEKLRKRLASQSRGLRGLWDCLPPDLVGRGS
A-R--CPAADRLEELQSCVSALVARHREAQQVLARLEEENQQLRGFPAR--CGEP-GASS
--EASASPQVEALEQDLGKLEEELQAVQATMSG--KSQEIRKLKQLLYQATEEVAELRAR
EAAGLQQHEQTRGSLVAQ----ARAWGRELKALLEKYNTACREMGRLREAVAEERRRSGD
LAARAAGQERQASELRGRSEQLEKTAELLKEKVEHLIGAGRDKEAKIKELLKKLEQLSEE
ILVVRGENAHL-ARQLQDSQKNHEEIISTYRNHLLNAARGYMEQDVYSILLRILSIQEE-
----------

--------------------------------------------------------MKRI
FSCSSSQVA-------------------VEKWNRRDQKLLEAVQRGDVSRVAALASRKTA
CPTKLDS

PF00023 // ENSGT00530000063369_3_Domain_1 (128, 166)

HGQSP---FH---LAASKGLTECLTVLLANGAEINSKN

ENSGT00530000063369_3_Linker_1_2 (166, 174)

E-------

PF00023 // ENSGT00530000063369_3_Domain_2 (174, 210)

DGSTALH
LATISCQPQCVKVLLQXXXXXXXX---X-XXXXXXXXXXX---XXXXXXXXXXXXXXXXX
XXXXXX---------

PF00023 // ENSGT00530000063369_3_Domain_5 (256, 288)

DGRTPVMIASLGGHAAICSQLLQRGARVNVTDKQDXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXYALRTQDKELWRLLRQALNRRHRG-GQGLAAH
PDLSSQXXX----XXXXX-------------XXXXXSPRTAEPEENDEEE--GGEDRCSP
HEWRRKYEAEKKKVSQLEQELIQKEEECKAQATACQGLESRVREQIQELGVLLARECQEE
GG-QGPSPRPGGDGMEQGCV---LDLLAEQVQELKRQKQVMAS--QV-------------
---LLRGPRYESQGSAQP-EEQRSPLQSPVEKAQGKAKGEQLANVGGVV-------PGQG
RGDQVLPLKEERG-------------RAPGAEPAGMV--------A-LGQLLLQLREELT
-AVWRDK-D---AARGVLGRPAGNRVWGASQAEAAAAAWEKMEARLEQVLARLDRAKAGL
SVETVPSLP---ESPEGALKPFPTSPT------TEGKAKEERAHE-ARGEPLGAPGGG--
---QAPE-GPGAKGQLEKEVSALRLSNSNLLEELSELGRERQRLQGELHALSQRLQREYM
PRPEAQDQLQQLRSSVGLLAEELAAEKEAAEQLRRRLEAQNTGLRGLRECLPSNLMGGGR
P-R--GPAPDALEELQGCVGALVTRYNEAQRELARLERENQRLKRWE-----------AV
--ASQAVPQVVALEQDLGKLEEELRAVQATMGG--KSQEIGKLKHLLYQATEEVAELRAR
EAVNLRQQEKSRASLVAQ----AQTWGQELKALLEKYNSACRETGQLREVVAEERRRSRE
LAARATEQERQASEMRGRSEQFEKAGELLKEKMDQLIGACREKEAKIRELLKKLEQMSAE
VLAVRGENTRL-LLQLQDSQKNHQEIISTYRNHLLNAAQGYMEQDVYKILLRILKMQE--
----------

--------------------------------------------------------MKRF
FSCSSSQVA-------------------VERWTRRDQKLLEAVQRGDVGRVAALASRKSA
RPTKLNS

PF00023 // ENSGT00530000063369_3_Domain_1 (128, 166)

NGQSP---FH---LAASKGLTECLTILLVNGADINSKN

ENSGT00530000063369_3_Linker_1_2 (166, 174)

E-------

PF00023 // ENSGT00530000063369_3_Domain_2 (174, 210)

DGSTALH
LATISCQPQCVKVLLQHGANEDAV---D-

ENSGT00530000063369_3_Linker_2_3 (210, 211)

A

PF00023 // ENSGT00530000063369_3_Domain_3 (211, 246)

ENRSPLHWAA---SSGCASSVLLLCDHEAF
LDVLD

ENSGT00530000063369_3_Linker_3_5 (246, 256)

N---------

PF00023 // ENSGT00530000063369_3_Domain_5 (256, 288)

DGRTPLMIASLGGHAAICSQLLQRGARVNVTD

ENSGT00530000063369_3_Linker_5_6 (288, 289)

K

PF00023 // ENSGT00530000063369_3_Domain_6 (289, 321)

DDKSALILACEK
GSAEVAELLLSHGADAGAADSLGHDALHYALGTQDKVLCRLLRQALDRRGQRAGQGLVQH
PDLAC----QASPSEPRV-------------GSPPKSPWRAEPEEEQEEE--EEEDPC-S
EEWRRKYEEEQRKVSQLEQELVRKTEEAKAQAAAYLGLENRIREQVQELGLLLSPEPGAP
GG-QGSGLRPGGDGMEQGCP---LGLLAERIQELRKQQQTAAAAAAAANAVLASKKAADS
---ASGEIQHEAHGRVQP-EERGP-PQSPRCETIGKATGQQLSTNGG-------QALGPE
YMDKPHAGPKERP-------------QAPGADPIGTVAEPAGPA-A-MNQLLLQLREELA
-AVWREK-D---AARGALSRPVLEGALGTPRAEAAAAAWEKMEARLEQVLVRLDRAKAGL
QGKPQAPAQ---EPREGAPKAGPATIT------KEHEGREKRAPG-ARGEPLGAPGGE--
---RTP-AGGPAKGQLEKEVVALRLSNSNLLEELGELGQERQRLQGELQSLSQRLQRDFV
PKPEAQVQLQQLRRSVGLLTDELATEKEATEKLRRRLASQSSGLRGLWDYLPPDLVGKGS
A----GRTAEPLEELQACISTLVEQHREAQKALARLEEENQQLRGPPAP--RGEP-GILS
--KAPAPPQVAALEQDLGKLEEELRAVQATMSG--KSQEIGKLKQLL-QATEEVAELRAR
EAASLRQHEKTRGSLVAQ----AQAWGQELKALLEKYNTACREMGRLREAVAEERRRSGD
LAARAAEQERQAGEMCARSQQFERTAEQFKDKVEHLIGACRDKEAKIKELLKKMEQLSEE
VLAVRGENARL-ALQLQDSQKNHEEIISTYRNHLLNAAQGYMEQDVYNILLRILSIQE--
----------

--------------------------------------------------------MKRI
FSCSSSQVA-------------------VEKWNRRDQKLL

PF12796 // ENSGT00530000063369_3_Domain_1 (101, 202)

EAVQRGDVGRVAALASRKSA
RPTKLDSNGQSP---FH---LAASKGLTECLTILLANGADINSKNE-------DGSTALH
LATISCQPQCVKVLLQHGANEDAV---D-AENRSPLHWAA---SSGCASSVLLLCDHEAF
LDVLDN---------DGRTPLMIASLGGHAAICSQLLQRGARVNVTDK

PF12796 // ENSGT00530000063369_3_Domain_6 (289, 342)

DDKSALILACEK
GSAEVAELLLSHGADAGAVDSLGHNALHYALRTQDKELWRLLQQALNRRRRG-GHGLVQH
PDHAS----QASPPEPQV-------------GSPPKSSWRAEPEEEE------EEASC-S
EEWRWKYEEEQKKVNQLQQELVRKTEECKAQTAAFIGLENQIREQVQELGHLLLQEPRAP
GR-QGPSLRPGGDGMEQGCP---LNLLAERIQELKRQQKAAAT----VNPTVVPRRAEEV
T-P-PAEIQYEVDRKSQP-E-QGP-PQSPRTETIGKATGHQLNTSGG-------QNLGLD
NTDQVCVGQKERS-------------PAPGVEQAGTVGEPVGIA-A-LNQLLLQLREELA
-AVWREK-D---AARGALSRPVLEGALGTPRAEAAAAAWEKMEARLERVLVRLDRAKAGL
QVKPEVPAQ---GSGEGAPKAVPGCTK------E---QEEKRVPG-ARGEPLGAPGGE--
---QAPV---LAKGHLEKEVSALRLSNSNLLEELGELGRERQRLQGELQSLTQRLQREFV
PKPEAQVQLQQLRRSVGLLTDELAIEKEATEKLRRRLASQSSGLQGLWNCLPPDLVGKGS
T-R--STAAEPLEELQTCISTLVDRHLEAQQKLARLEEENQQLRGSLAP--HPEP-EASL
--KGTASPQVAALEQDLGKLEEELRAVQATMSG--KSQEICKLKQLLYQATEEVAELRAR
EAASLRQHEKTRGSLVAQ----AQAWGQELKAVLEKYNTACREMARLRDAAAEERRRSED
LAARAAEQERQAGEMRGRSEQFEKTAELLKEKTDHLIGACRDKEAKIKELLKKLEQLSEE
VLEVRGENAHL-ALQLQDSQKHHEEIISTYRNHLLNSAQGYMEQDVYNILLGILSMQE--
----------

--------------------------------------------------------MKRI
FSCSSSQVA-------------------VERWNRRDQKL

PF12796 // ENSGT00530000063369_3_Domain_1 (100, 202)

LEAVQRGDVVRVAALASRKSA
RPTKPNSNGQSP---FH---LAASKGLTECLTILLANGADVNSKNE-------DGSSALH
LATISCQPQCVKVLLQHGANE

ENSGT00530000063369_3_Linker_1_3 (202, 211)

DAV---D-A

PF12796 // ENSGT00530000063369_3_Domain_3 (211, 287)

ENRSPLHWAA---SSGCASSVLLLCDHEAF
LDVLDN---------DGRTPLMIASLGGHAAICSQLLQRGARVNVTDKDDKSALILACEK
GSAEVAELLLSHGADAGAVDSTGHDALHYALHAQDKSLQRLLQQALNRRR--GGQGLVQH
PDLAS----QASPSEPQA-------------GSSPKTPWRAEPEEEQEEE--KDEDPC--
--WRWKFEEEHRKVSQLEQDLVQKTEEWKAQAAAYLGLENRIQEQAQELGLLLSREPRAS
GG-QGSSHRPGGDGMEQGRP---LDLLAERIRELKKQQQAAVT----VNSVLAPKNAEDS
---APGEIQYQVRGRSQA-EEQEL-PQSPGSETIRKATRQQLTKDGG-------QTLGPD
HADQMPAGQKERS-------------QVLGVEPGGTVAEPAGPA-A-MNQLVLQLREELA
-AVWREK-D---AARAALSRPDMEGALGTPRAEAAAAAWEKMEARLERVLARLDRAKAGL
QVKPEVPAQ---ESRERAPKAAPGSVR-------EDEEKEKSVPG-ARGEPLGAPGGE--
---QA--LGGLAKGQLEKEVSALRLSNSNLLEELGELGRERQRLQRELQSLSQRLQREFV
PKPEAQVQLQQLQQSVGQLTDELAAEKEAAEELRRRLASQSSSLRGLWDCLPADLVGKRS
A-R--SEAAEPPEELRACISTLADRHREAQHVLARLREENRQLRGSLSP--CGEP-GTSF
--KVPASPQVAALEQDLGKLEEELRAVQATMSG--KSQEIGKLKQLLYQATEEVAELRAR
EAASLRQHEKTRGSLVAQ----AQAWGQELKALLEKYNAACREMGRLREAVAEERRRSGD
LAARAVEQERQASEMRGRSERLEKTAELLKEKMERLIGACRDKEAKIKELLKKLEQLSEE
VLAIRGENARL-ALQLQDSQKNHEEIISTYRNHLLNAARGCMEQDVYNILLRILSMQEE-
----------

MPPGSCCWRAQSREESRPEPARGRSAASSRLRVRWVWEPVARLSARPRPPVALTPAMKRI
FSCSSSQVA-------------------VERWNRRDQKLL

PF12796 // ENSGT00530000063369_3_Domain_1 (101, 202)

EAVQRGDVGRVAALASRKSA
RPTKLDSNGQSP---FH---LAASKGLTECLTILLANGADINSKNE-------DGSTALH
LATISCQPQCVKVLLQHGANE

ENSGT00530000063369_3_Linker_1_3 (202, 211)

DAV---D-A

PF12796 // ENSGT00530000063369_3_Domain_3 (211, 287)

ENRSPLHWAA---SSGCASSVLLLCDHEAF
LDVLDN---------DGRTPLMIASLGGHAAICSQLLQRGARVNVTDKDDKSALILACEK
GSAEVAELLLGHGADAGAMDRTGHDALHYALHTQDKALWRLLRQALNRRRRGGGQRLVQY
PDLAS----QVSPSEPQM-------------GSPPKSPWRAEPEEEQEEE--DDEDPC-S
EEWKWKYEEEQRKVSQLEQELVCKTEECKTQAAAYLGLENQIREQVKELGLLLSQEPAAS
GR-RGSSLRLGGDGMEQGCP---LDLLVERIQELKKQQQVAAT----VNPTLAPRKAEDS
---APGEVQYEVHGRFQP-QEQGP-LQSPRSVTIGKTTEQQLTTNGG-------HTLGLD
HPNQLPAGQKERP-------------QAPGVEPAGTVVEQVGTA-A-MNQLLLQLREELA
-AVWREK-D---AARGALSRPVLEGALGTPRAEAAAAAWEKMEARLERVLVRLDRAKAGL
QVKP---AQ---ESREGAPKAAPGSIR------EN--EEEKRSPG-ARGEPLGAPGGE--
---QAP-GGGLPKGQLEKEVSALRLSNSNLLEELGELGRERQRLQRELQSLSQRLQREFV
PKPEAQVQLQQLRQSVGLLTDELAMEKEATEKLRKRLASQSSGLRGLWDCLPPDLVGKGS
T-R--STLAEPLEELQGCISTLVDRHREAQQVLARLEEENQQLRGSLAP--GGEP-GISS
--RAPASPQVAALEQDLGKLEEELRVVQATMSG--KSQEIGKLKQLLYQATEEVAELRAR
EAASLRQHEKTRGSLVAQ----AQAWGQELKALLEKYNTACQEMGRLREAMAEERRRNGE
LAAQAAEQEQQAREMRGRSEQFEKTAELLKEKMEHLIGACRDKEAKIKELLKKLEQLSEE
VLAVRGENARL-VLQLQDYQKNHEEIISTYRNHLLNAARGIRASLVDRGSIRLWWVGGLA
IKRWCGQGYT

--------------------------------------------------------MKRI
FSCSSSQVA-------------------VERWNRRDQKLL

PF12796 // ENSGT00530000063369_3_Domain_1 (101, 202)

EAVQRGDVGRVAALASRKLA
RPTKLDSNGQSP---FH---LAASKGLTECLTVLLANGADINSKNE-------DGSTALH
LATISCQPQCVKVLLQHGANEDAV---D-AENRSPLHWAA---SSGCASSVLLLCDHEAF
LDVLDN---------DGRTPLMIASLGGHAAICSQLLQRGARVNVTDK

PF12796 // ENSGT00530000063369_3_Domain_6 (289, 343)

DDKSALILACEK
GSAEVAELLLSHGADAGAVDSSGHNALHYALRTQDQALWTLLQQALNRRRRG-GPRLVQY
PDHAS----QTSPSEPLL-------------GSPPKSSWRAEPEEEQEEE--EDEERY-S
DEWRWKYEEERKKVSQLEQELVRKMEECKVQAAAFLGLENQIREQVQELGLLLSQEPGAP
AR-QGLGLRPGGDGMEEGCP---LNLLVERIQELKKQQQSRAT----VNPLVSKSVGE--
--SAPAEIQCEVL------EPQGL-PQSPRSETTGKATGQQLTTNRG-------QALDLD
DIDKVCADQKERS-------------QVLGIEPVGLMAEPVSTT-A-MNQLLLQLMEELA
-AVWREK-D---AARGALSRPFLEGALGTPRAEAAAAAWEKMEARLERVLVRLDRAKAGL
QVKPEAPA----------PKVAPGCIK------EL--EEKKGAPG-ARGEPLGAPGEQ--
---AS--GGGPAKGQLEKEVSALRLSNSNLLEELGELGRERQRLQGELQSLSQRLQREFV
PKPEAQVQLQQLRRSMGLLKEELAVEKEATEKLRRRLASQSSGLQGLWDCLPADLVSKGR
V-Q--NTAAEPLEELQTCISTLVDKHREAQQMLAQLQEENQQLRGSLTP--CGEP-EASS
--KATASPQVAALEQDLGMLEEELRAVQATMSG--KSQEIGKLKKLLYQATEEVAELRAR
EAASLRQHEKTRGSLVAQ----AQAWGQELKVVLEKYNTACREMGRLRDAAAEERRRSED
LAARAAEQERQTCEMRGRSEQFEKTAELLKEKMDHLIGACRDKEAKIKELLKKLEQLSEE
VLAVRGENTHL-ALQLQDSQKNHEEIISTYRSHLLNAARGYMEQDVYNILLRILSMQE--
----------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------

PF00023 // ENSGT00530000063369_3_Domain_6 (291, 321)

RTALILACQQ
GHLEVAELLLQNGADVSIADKTGRDALHYSAQNKNKKLRRLVQNALRKRKKKGEESGGSC
S--------SARPSSPSFERIFSLFPQNKASIFPPR----PSPR--------ERGLNC-E
KEWRSRYREEKLKVIQLELAL-QKVRECEALSEGSKAVKERVWDQVQEINQILPDRDGES
RGWNELSQRYNRDATDEDYS---LNLLAEQVRELKRRKERTEKEKEEKKGS----SSQNE
T-SQPREVQWPGVEDEEERRRHETSGYSPRGEDRSPETGARDGGTHGEH------ESGH-
QGLRIQEEAPERG-------------RGPGSRTGGG--EPTSPR-D-VDKVLTEMEATYE
-KTQKEN-EATKAENAALKKKAV--------------------EGLEGALDKVERAHSML
LEKARPLRKD--ISLE---VVNNGCHVEKNISKDENAKDAEKARNEAGNAMLGKNGEVKL
RLTESKARPCRKSSDLEKEVWDLKQNNGHLATELSRLSKEREKLQQELRTLCGPKEGS--
---RQLEMIEELKRRVELLSKELFAEKEVSEKLRLELAAQAKETAAMKARFLEKMEAT-S
LFGAETLNSCILKELHWKLDNVAKKQSKALQLVSEMEEENFNQSFHQSE--RTVPD-IP-
VEALDAVGDNSKVRQVLVELEDVLRELKEALDGAEKNEVVSKLKGLVDRMVAAMATLRQE
EEEALRKHEKVRGMLSVR----AQVLAEELATLRDKFEEARGEAGRRAEALESEARMNRD
LLEEMAEHEEEVEELRGKSRRMESTIESLGKKVEELSKAGQEKEAKFKKLLKETEKLSSE
ILNLRSERTRL-LLQNEVAQKNHQEIVAIYRTHLLNAAQGFMDKEVHEMLQRILRTR---
----------

--------------------------------------------------------MKRI
FSCSSSQVA-------------------VEKWNRRDQKLL

PF12796 // ENSGT00530000063369_3_Domain_1 (101, 202)

EAVQRGDVGRVAALASRKSA
RPTKLDSNGQSP---FH---LAASKGLTECLTILLANGADINSKNE-------DGSTALH
LATISCQPQCVKVLLQHGANE

ENSGT00530000063369_3_Linker_1_3 (202, 211)

DAV---D-A

PF12796 // ENSGT00530000063369_3_Domain_3 (211, 287)

ENRSPLHWAA---SSGCASSVLLLCDHEAF
LDVLDN---------DGRTPLMIASLGGHAAICSQLLQRGARVNVTDKHDKSALILACEK
GSAEVAELLLSHGADAGAVDSLGHNALHYALHTQDTELWRLLQQALNRRRRG-GHGLVQH
PDHPS----QASSSEPPV-------------GSPNKSSRKVKPEEEQEGE--EGEERC-S
EEWRWKFEEEQRKVNQLEQELLRKTDECKARAAAFSSLEDQIREQVQELGHLLVQEPGAP
GN-QGPGLRPEGDGMEQGCP---LNLLAERIQELKKQQKALAT----INPTGVPERAEDL
--A-LAELHHEVHRKSQP-E-QGL-PQGPGSETTGKTTGQQPNTSEG-------QNLGLQ
NTEQVCASQKERA-------------PAPGTEPAGTVGEPVGIA-A-MNQLLLQLREELA
-AVWREK-D---AARGALSRPVLEGALGTPRAEAAAAAWEKMEARLERVLVRLDGAKMGL
HVKSEVPVQ---GPREGAQKAVPGCSK------E---QEEKKAPG-TRGEPLGAPGRE--
---QA-SGGGLAKGQLEKEVSALRLSNSNLLEELGELGRERQRLQGELQSLTQRLHREFV
PKPEAQVQLQQLRRSVGMLTEELAMEKEATDKLRRRLASQTSGLQGLWNCLPPDLVGKGS
A-Q--STAAEPLEELQACISTLVDRHLEAQQVLAQLKEENQQLRGSLAP--CGEP-EASL
--KATASPQVAALEEDLGKLEEELRAVQATMSG--KSQEICKLKQLLYQATEEVAELRAR
EAASLRQHEKTRGSLVAQ----AQAWGQELKVVLEKYNTACREMTRLRDTVAEERRRSED
LAARAAEQERQAGEMRGRSEQFEKTAELLKEKTNHLIGACRDKEAKIKELLKKLEQLSEE
VLEVRGENAHL-ALQLQDSQKNHEEIISTYRSHLLNAARGYMEQDVYNILLRILSMQE--
----------

------------------------------------------------------------
----------------------------VEKWNRSDQKLLAV--AGDVGRVAALAXXXXX
XXXXXXXXXXXXXXXXX---XXXXXXXXXXXXXX---XXXXXXX-------XXXXXXXXX
XXXXXXXXXXXXXXXXHGANEDAV---D-A

PF00023 // ENSGT00530000063369_3_Domain_3 (211, 246)

ENRSPLHWAA---SSGCASSVLLLCDHEAF
LDVLDNXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX----XXXXX-XXXXXXXXXX-
X---XX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXQGLVQH
PEATS----KASLSEAQV-------------GSPPKSPWRAEPEEEEEEE--EEEDPS-S
EEWRWKYEEEQRKVAVLEQELGRKTEECKTQAAAYLVLENQIREHVQDLGNLLAKDPGVP
GG-QGSALRPGGDGMEQGCP---LDLLAERIQELKKQQQAAAAVNAALQ------KREDS
---KPGTIQHEAKGRPQP-DDEGP-PQSPRSKTIVKAAGQQVTSTGE-------HVTGPD
HAD------QERP-------------QASGAEPTDMGFERAGVA-A-VNQLLLQLREELA
-AVWREK-D---AARGALSKSILEGPMGTPRAEAAAAAWEKMEARLXXXXXXXXXXXXXX
XXXXXXXXXX--XXXXXXXXXXXXXXX------X-XXXXXXXXXX-XXXXXXXX-XXX--
---X-X-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXSLTQRLQREFV
PKPEAQVQLQQLRRSVGLLTEELATE-EATEKLRERLASQTSSLRGLWDCLPADLVGQGG
A-R--DPEAQPLEELQACVRTLVQRHREAQRALAQLEEENRQLRGSPAP--RGEP-GVPT
--AAPAAPQVAALEQDLGKLEEELRAVQATMSG--KSQEIGKLKQLLYQATEEVAELRAR
EAANLRQHEKTRGSLVAQ----AQAWGQELKALLEKYNVACREMGRLREAVAEERRRSGE
LAARAAEQESRAGEMRGRCEQFEKTAELLKEKMEHVVGACRDKEAKIKELLKKLEQLSEE
VLEVRGENTRL-ALQVQDSQKNHEEIISTYRNHLLNAAQGYMEQDVYNILLRILSLQEG-
----------

--------------------------------------------------------MKRI
FSCSSTQVA-------------------VERWNRHDQKLLEAVHRGDVG

PF12796 // ENSGT00530000063369_3_Domain_1 (110, 202)

RVAALASRKSA
RPTKLDSNGQSP---FH---LAASKGLTECLTILLANGADINSKNE-------DGSTALH
LATISCQPQCVKVLLQHGANEDAV---D-AENRSPLHWAA---SSGCASSVLLLCDHEAF
LDVLDN---------DGRTPLMIASLGGHAAICSQLLQRGARVNVTD

PF12796 // ENSGT00530000063369_3_Domain_6 (288, 343)

KNDKSALILACEK
GSAEVAELLLSHGADAGAVDSTGHDALHYALHTQDKALWRLLQQALNRRRRG-GQRLVQH
PDLAS----QASPSEPQA-------------GSPPKSSWRAEPEEEQEEK--EDEDPC-S
EEWRWKYEEERRKVVQLEQELVQKTEECKTQAAAYLDPENQIREQAQELGVLLSWEPRAS
GK-QGSSLRPGGDGMEQGCP---KDMLAESTQELKKQ-QQAAA---TVNPVLAPKKAEDS
---APGKIQYEVHGRSQP-EEQGP-PQSPASETIRKVTGQQLPTNGA-------QTFGPD
HADQLPAGQKESS-------------QVLGVEPGGTVAEPVSPA-A-MNQLLLQLREELA
-AVWREK-D---AARGALSRPVMEGALGTPRAEAAAAAWEKMEARLERVLARLEWAKAGL
QVKPEVPSQ---ESREGALKAPPGSIK-------QDEEKEKRVPG-ARGEPLGALGGA--
---KA--LGGLAKGQLEKEMSVLRLSNSNLLEELGELGRERQRLQRELQSLTQRLQREFV
PKPEAQVQLQQLRQSVGLLTNELAMEKEATEKLRKLLASQSSGLRGLWDCLPADLVGKRS
A-Q--SKAAESLEELRACISTLVDRHREAQQVLARLQEENQQLRGSLSP--CREP-STSL
--KAPASPQVAALEQDLGKLEEELRAVQATMSG--KSQEIGKLKQLLYQATEEVAELRAR
EAASLRQHEKTRGSLVAQ----AQAWGQELKALLEKYNTACREMGRLREAVAEERRRSGD
LAAQAAEQERQASEMRGRSEQFEKTAELLKEKMEHLIGACRDKEAKIKELLKKLEQLSEE
VLAIRGENARL-ALQLQDSQKNHEEIISTYRNHLLNAARGYMEHEVYNILLQILSMEEE-
----------

--------------------------------------------------------MKRI
FSCSSTQVA-------------------VERWNRHDQKLLEAVHRGDVG

PF12796 // ENSGT00530000063369_3_Domain_1 (110, 202)

RVAALASRKSA
RPTKLDSNGQSP---FH---LAASKGLTECLTILLANGADINSKNE-------DGSTALH
LATISCQPQCVKVLLQHGANEDAV---D-AENRSPLHWAA---SSGCASSVLLLCDHEAF
LDVLDN---------DGRTPLMIASLGGHAAICSQLLQRGARVNVTDK

PF12796 // ENSGT00530000063369_3_Domain_6 (289, 332)

NDKSALILACEK
GSAEVAELLLSHGADAGAVDSTGHDALHYALHTQDKALWRHLQQALSRRRRG-GQRLVQH
PDLAS----QASPSEPQA-------------GSPPKSSWRAEPEEEQEEK--EDEDPC-S
EEWRWKYEEERRKVVRLEQELVQKTEECKTQAAAYLDLENQIREQAQELGVLLSWEPRAS
GK-QGSSLRPGGDGMEQGCP---KDLLAESTQELKKQ-QQAAA---TVNPVLAPKKAEDS
---APGKIQYEVHGRSQP-EEQGP-PQSPASETIRKATGQQLTTNGA-------QTFGPD
HADQLPAGQKESS-------------QVLGVEPGGTVAEPVGPA-A-MNQLLLQLREELA
-AVWREK-D---AARGALSRPVMEGALGTPRAEAAAAAWEKMEARLERVLARLEWAKAGL
QVKPEVPSQ---ESREGALKAAPGSIK-------QDEEKEKRVPG-AQGEPLGALGGE--
---KA--LGGLAKGQLEKEMSVLRLSNSNLLEELGELGRERQRLQRELQSLSQRLQREFV
PKPQAQVQLQQLRQSVGLLTNELAMEKEATEKLRKLLASQSSGLRGLWDCLPADLVGERS
A-Q--SKAAESLEELRACISTLVDRHREAQQVLARLQEENQQLRGSLSP--CREP-GTSL
--KAPASPQVAALEQDLGKLEEELRAVQATMSG--KSQEIGKLKQLLYQATEEVAELRAR
EAASLRQHEKTRGSLVAQ----AQAWGQELKALLEKYNTACREVGRLREAVAEERRRSGD
LAAQAAEQERQASEMRGRSEQFEKTAELLKEKMEHLIGACRDKEAKIKELLKKLEQLSEE
VLAIRGENARL-ALQLQDSQKNHEEIISTYRNHLLNAARGYMEHEVYNILLQILSMEEE-
----------

--------------------------------------------------------MKRI
FSCSSSQVA-------------------VERWNRRDQKLL

PF12796 // ENSGT00530000063369_3_Domain_1 (101, 202)

EAVQRGDVGRVAALASRKSA
RPTKLDSNGQSP---FH---LAASKGLTECLTLLLANGADINSKNE-------DGSTALH
LATISCQPQCVKVLLQHGANEDAV---D-AENRSPLHWAA---SSGCASSVLLLCDHEAF
LDVLDN---------DGRTPLMIASLGGHTAICSQLLQRGARVNVTDK

PF12796 // ENSGT00530000063369_3_Domain_6 (289, 342)

NDKSALILACEK
GSAEVAELLLSHGADAGAVDSTGHDALHYALHTQDKSLWRLLQQALNRRQRG-GQRLVQH
PDLAS----QASPSEPQA-------------GSPPKSPWRAEPEEEQEEE--EDEDPC-S
EEWRWKYEEEQRKVVQLEQELVQKTEECKTQAAACLRLENQIREQVQELGLLLSWEPRAS
GR-QGSSLRPGGDGMEQGCP---MDLLAERIQELKRQ-QQAAA---TVNPVLALKKAEDS
---APGEIQYEVHGRSQQ-EEQGP-PQSPESETIRKTTGQQLTTSGA-------QTFGHD
HADQLPAGQKESS-------------QVLGVEPGGTVAEPVGPA-A-MNQLLLQLREELA
-AVWREK-D---AARGALSRPVMEGALGTPRAEAAAAAWEKMEARLECVLARLERAKAGL
QVKPEVPSQ---ESREGALKAAPGSIR-------EVEEKEKRVPG-ARGEPLGAAGGE--
---KA--LGGLAKGQLEKEVSALRLSNSNLVEELGELGRERQRLQRELQSLSQRLQREFV
PKPEAQVQLQQLRQSVGLLTDELAVEKEATEKLRKLLAAQSSGLRGLWDCLPPDLVGKRS
A-Q--SKAAEPLEELRACITTLVDRHREAQQVLARLQEENRQLRGSLSP--CREP-GTSL
--KAPASPQVAALEQDLGKLEEELRAVQATMSG--KSQEIGKLKQLLYQATEEVAELRAR
EAASLRQHEKTRGSLVAQ----AQAWGQELKALLEKYNTACREMGRLREAVAEERRRSGD
LAAKAAEQERQASEMRGRSEQFEKTAELLKEKMEHLIGACRDKEAKIKELLKKLEQLSEE
VLAIRGENARL-ALQLQDSQKNNEEIISTYRNHLLNAARGYMEHEVYNILLRILSMQEE-
----------

--------------------------------------------------------MKRI
FSCSSSQVA-------------------VERWNRRDQKLLEAVQRGDVGRVAALASRKSA
RPTKLDS

PF00023 // ENSGT00530000063369_3_Domain_1 (128, 165)

NGQSP---FH---LAASKGLTECLTILLANGADVNSKNED-----ELGHAACL
HLYSSCGGRCW-ALLEHGANEDAV---D-AENRSPLHWAA---SSGCASSVLLLCDHEAF
LDVLDN---------DGRTPLMIASLGGHAAICSQLLQRGARVNVTDK

PF12796 // ENSGT00530000063369_3_Domain_6 (289, 342)

DDKSALILACEK
GSAEVAELLLSHGADAGAVDSTGHDALHYALHTQDKSLWRLLQQALNR-RRG-GQGLVQH
PDLAS----QASPSEPQA-------------GSSPKTPWRAEPEEE------EDEDPC-S
EEWRWKFEEEHRKVSQLEQELVQKTDEWKAQAAAYLDLENQIQEQAQELGLLLSREPRAS
GG-QGSSLRPGGDGMEQGRP---LDLLAERIQELKKQQQAAAT----VNSVLAPEKAEDS
---ATGEIQYEVHGRSQP-EEQKL-PQSPGSETIRKATGQQLTKDGG-------QTLGPD
HVDQMPAGQKERP-------------QVLGVEPGGTVAEPAGPA-A-MNQLLLQLREELA
-AAWREK-D---AARAALSRPVMEGALGTPRAEAAAAAWEKMEARLERVLARLDRAKAGL
QVKPEIPSQ---ESGEGTPKAAPGSIK------ED--EEEKSVPG-ARGEPLGAPGGQ--
---QA--LGGLAKGQLEKEVSALRLSNSNLLEELGELGRERQRLQRELQALSQRLQREFM
PKPEAQDRLQQLQQSVGLLTDELAVEKEATEELRRRLASQSSSLRGLWDCLPPDLVGKRS
A-R--SEAAEPPEELRACISTLADRHREAQQVLARLREENRQLRGSLSP--CGEQ-GTSF
--KVPASPQVAALEQDLGKLEEELRAVQATMSG--KSQEIGKLKQLLYQATEEVAELRAR
EAASLRQHEKTRGSLVAQ----AQAWGQELKTLLGKYNAACREVGRLREAVAEERRRSGD
LAARAAEQERQASEMRGRSEQFEKTAELLKEKMERLIGACRDKEAKIKELLKKLEQLSEE
VLAIRGENARL-ALQLQDSQKNHEEIISTYRNHLLNAARVS--MDVYNILLRILSMQEE-
----------

--------------------------------------------------------MKRI
FSCSSSQVA-------------------VERWNRRDQKLLEAVQRGDVGRVAALASRKSA
RPTKLDS

PF00023 // ENSGT00530000063369_3_Domain_1 (128, 165)

NGQSP---FH---LAASKGLTECLTILLANGADINSK

ENSGT00530000063369_3_Linker_1_2 (165, 174)

NE-------

PF00023 // ENSGT00530000063369_3_Domain_2 (174, 208)

DGSTALH
LATISCQPQCVKVLLQHGANEDAV---D-AENRSPLHWAA---SSGCASSVLLLCDHEAF
LDVLDN---------

PF00023 // ENSGT00530000063369_3_Domain_5 (256, 288)

DGRTPLMIASLGGHAAICSQLLQRGARVNVTD

ENSGT00530000063369_3_Linker_5_6 (288, 291)

KND

PF00023 // ENSGT00530000063369_3_Domain_6 (291, 320)

KSALILACEK
GSAEVAELLLSHGADAGAVDGTGHDALHYALRTQDRTLWRLLRQALNRQGRG-GQGPVQH
LNPAS----QASPSESQV-------------GASPKSPWRAEPEEEQEEE--EDEDPC-S
EEWKWKYEEEKRKVSQLEQELLQKMEECKAQATAYLGLENQIQEHVRELGLLLSQEPRAP
GD-QGSSLRPGGDGMEQGCA---LNLLAKHIQELKKHQQATAA--AAANPVLASKKAEDS
--V-SGEIQYEAQGRSQP-E-QEP-PQNPKSETVGETTGQQLTNSDG-------QALCLD
HTDQLFAGQKERP-------------QAPGSEPTSTVAEPVGTA-A-MNQLLLQLREELA
-AVWREK-D---AARGALSRPVLEGALGTPRAEAAAAAWEKMEARLEQVLVRLDRAKAGL
QMKPQAPAQ---EPREEAPKALPGTIT------QEDEEKEKRVPG-ARGEPLGAPGGD--
---QMA-GGGQARGQLEKEVSALRLSNSNLLEELGQLGRERQRLQGE-----QRLQREFV
PRPEAQVQLQQLRRSVELLTDELALEKEATEKLRKRLASQNRGLQGLWDCLPPDLVGQGS
A-R--GT-AEPLEDLQACISALVARG------VCRLQGETDQRRGPPSR--RGEP-GVST
--KGSASPQVAALEQDLGKLEEELRAVQATMSG--KSQEIGKLKQLLYQATE-------R
EAASLRQHEKTRGSLVAQ----AQAWGQELKALLEKYNTACREMGRLREAAAEERRRSGD
LATRAAEHERQASEMRGRSEQFEKTAELLKEKVEHLIGACRDKEAKIKELLKKLEQLSEE
VLAVRGDNARL-ALQLQDSQKNHEEIISTYRKHLLNAAQGYMEQDVYNILLRILSIQE--
----------

--------------------------------------------------------MKRI
FSCSSSQVA-------------------VEKWNRRDQKLL

PF12796 // ENSGT00530000063369_3_Domain_1 (101, 202)

EAVQRGDVGRVAALASRKSA
RPTKLDSNGQSP---FH---LAASKGLTECLTILLANGADINSKNE-------DGSTALH
LATISCQPQCVKVLLQHGANEDAV---D-AENRSPLHWAA---SSGCASSVLLLCDHEAF
LDVLDN---------DGRTPLMIASLGGHAAICSQLLQRGARVNVTD

PF12796 // ENSGT00530000063369_3_Domain_6 (288, 342)

KDDKSALILACEK
GSAEVAELLLSHGADAGAVDSLGHNALHYALRTQDKELWRLLQQALNRRRRG-GHGLVQH
PDHAS----QASPPEPQV-------------GSPPKSSWRAEPEEEE------EEASC-S
EEWRWKYEEEQKKVNQLQQELVRKTEECKAQTAAFIGLENQIREQVQELGHLLLQEPRAP
GR-QGPSLRPGGDGMEQGCP---LNLLAERIQELKRQQKAAAT----VNPTVVPRRAEEV
T-P-PAEIQYEVDRKSQP-E-QGP-PQSPRTETIGKATGHQLNTSGG-------QNLGLD
NTDQVCVGQKERS-------------PAPGVEQAGTVGEPVGIA-A-LNQLLLQLREELA
-AVWREK-D---AARGALSRPVLEGALGTPRAEAAAAAWEKMEARLERVLVRLDRAKAGL
QVKPEVPAQ---GSGEGAPKAVPGCTK------E---QEEKRVPG-ARGEPLGAPGGE--
---QAPV---LAKGHLEKEVSALRLSNSNLLEELGELGRERQRLQGELQSLTQRLQREFV
PKPEAQVQLQQLRRSVGLLTDELAIEKEATEKLRRRLASQSSGLQGLWNCLPPDLVGKGS
T-R--STAAEPLEELQTCISTLVDRHLEAQQKLARLEEENQQLRGSLAP--HPEP-EASL
--KGTASPQVAALEQDLGKLEEELRAVQATMSG--KSQEICKLKQLLYQATEEVAELRAR
EAASLRQHEKTRGSLVAQ----AQAWGQELKAVLEKYNTACREMARLRDAAAEERRRSED
LAARAAEQERQAGEMRGRSEQFEKTAELLKEKTDHLIGACRDKEAKIKELLKKLEQLSEE
VLEVRGENAHL-ALQLQDSQKHHEEIISTYRNHLLNSAQGYMEQDVYNILLGILSMQE--
----------

--------------------------------------------------------MKRI
FSCSSSQVA-------------------VERWNRRDQKLL

PF12796 // ENSGT00530000063369_3_Domain_1 (101, 202)

EAVQRGDVGRVAALASRKSA
RPTKLDSNGQSP---FH---LAASKGLTECLTLLLANGADINSKNE-------DGSTALH
LATISCQPQCVKVLLQHGANE

ENSGT00530000063369_3_Linker_1_3 (202, 211)

DAV---D-A

PF12796 // ENSGT00530000063369_3_Domain_3 (211, 287)

ENRSPLHWAA---SSGCASSVLLLCDHEAF
LDVLDN---------DGRTPLMIASLGGHTAICSQLLQRGARVNVTDKNDKSALILACEK
GSAEVAELLLSHGADAGAVDSTGHDALHYALHTQDKSLWRLLQQALNRRQRG-GQRLVQH
PDLAS----QASPSEPQA-------------GSPPKSPWRAEPEEEQEEE--EDEDPC-S
EEWRWKYEEEQRKVVQLEQELVQKTEECKTQAAACLRLENQIREQVQELGLLLSWEPRAS
GR-QGSSLRPGGDGMEQGCP---MDLLAERIQELKKQ-QQAAA---TVNPVLALKKAEDS
---APGEIQYEVHGRSQQ-EEQGP-PQSPESETIRKTTGQQLTTSGT-------QTFGHD
HADQLPAGQKESS-------------QVLGVEPGGTVAEPVGPA-A-MNQLLLQLREELA
-AVWREK-D---AARGALSRPVMEGALGTPRAEAAAAAWEKMEARLECVLARLERAKAGL
QVKPEVPSQ---ESREGALKAAPGSIK-------EDEGKEKRVPG-ARGEPLGAPGGE--
---KA--LGGLAKGQLEKEVSALRLSNSNLVEELGELGRERQRLQRELQSLSQRLQREFV
PKPEAQVQLQQLRQSVGLLTDELAVEKEATEKLRKLLAAQSGGLRGLWDCLPPDLVGKRS
A-Q--SKAAEPLEELRACITTLVDRHREAQQVLARLQEENRQLRGSLSP--CREP-GTSL
--KAPASPQVAALEQDLGKLEEELRAVQATMSG--KSQEIGKLKQLLYQATEEVAELRAR
EAASLRQHEKTRGSLVAQ----AQAWGQELKALLEKYNTACREMGRLREAVAEERRRSGD
LAAKAAEQERQASEMRGRSEQFEKTAELLKEKMEHLIGACRDKEAKIKELLKKLEQLSEE
VLAIRGENARL-ALQLQDSQKNNEEIISTYRNHLLNAARGYMEHEVYNILLRILSMQEE-
----------

------------------------------------------------------------
-----------------------LSFLPVERWNRRDQKLL

PF12796 // ENSGT00530000063369_3_Domain_1 (101, 202)

EAVQRGDVGRVAALASRKSA
RPTKLNSNGQSP---FH---LAASKGLTECLTILLANGADINSKNE-------DGSTALH
LATISCQPQCVKVLLQHGANE

ENSGT00530000063369_3_Linker_1_3 (202, 211)

DAV---D-A

PF12796 // ENSGT00530000063369_3_Domain_3 (211, 287)

ENRSPLHWAA---SSGCASSVLLLCDHEAF
LDVLDS---------DGRTPLMIASLGGHAAICSQLLQRGARVNVTDKDNKSALILACEK
GSAEVAELLLSHGADAGAVDSLGHDALHYALRTQDNVLWELLHRALNRRRRGGK------
-------------------------------------------------------IFC--
------------------------------------------------------------
-------------PFKQGCP---LNLLARHIQELKQQQGAVRV-----TPNTAPSRAEAS
---APAEVPRE----------AHGPPQSPRSEDIRKATGEQATATHG-------------
------------------------------GQTPSTEAEPVGAA-G-MHQLLLQLREELA
-AVWREK-D---AAKGALSRPVLEGALGTPRAEAAAAAWEKMEARLERVLVRLDRAKAGL
QAKPESPSHG--ESRAGAPRAGPGCAR--------EREEKKRAAG-ARGEPLGAPGEQ--
---A-P-GGCPAKGPLEKGVSALRLNNSNLLEELGELGRQRQLLQGELQALNQRLQREFM
PKPGEQDQLQQLQRSVGLLTLELATEKNATEKLRRRLAFQSSGLRGLWDCLPPDLVGHGK
A----PSADEPLDELRACISTLVDGHREAQQALAGLRKENEQLRASVPSCACGEPRDAPS
AGASSTAPQVAALEHDLGQLEEELRAVQATMSG--KSQEIAKLRQLLYQATEEVAELRSR
EAASLRQQEKARGSLAAQ----AQAWGQELQVVLDKYNSACREASRLREALAE-------
-------QERLADEARARCRRFENCTELLRERTEHLAGACRDKEGKIKELLKKLEQLSEE
VLAVQGENAHL-TLKLQDSQKNHEDIISTYRNHLLNAARGYMEQDVYNILLRILSMKE--
----------

--------------------------------------------------------QKRI
GGITNLQKQ-------------------FESWNKQDQKLLDAVEKGDVGRVSALMAKKAA
KPTKLNAL

PF00023 // ENSGT00530000063369_3_Domain_1 (129, 166)

GQSA---FH---LAASKGLIECLTILLMNGAQINDTNN-------DGSTALH
LATIACQPQCVKVLLQPFLDAPPASCSFATKKPFSMSWIM---LNIVP------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------

--------------------------------------------------------MKRI
FSCSSSQVA-------------------VERWNRHDQKLL

PF12796 // ENSGT00530000063369_3_Domain_1 (101, 202)

EAVQRGDVGRVAALASRKSA
RPTKLDSNGQSP---FH---LAASKGLTECLTLLLANGADINSKNE-------DGSTALH
LATISCQPQCVKVLLQHGANE

ENSGT00530000063369_3_Linker_1_3 (202, 211)

DAV---D-A

PF12796 // ENSGT00530000063369_3_Domain_3 (211, 287)

ENRSPLHWAA---SSGCASSVLLLCDHEAF
LDVLDN---------DGRTPLMIASLGGHTAICSQLLQRGARVNVTDKNDKSALILACEK
GSAEVAELLLSHGADAGAVDSTGHDALHYALHTQDKSLWRLLQQALNRRRRG-GQRLVQH
PDLAS----QASPSEPQA-------------GSPPKSPWRAEPEEEQEEE--EDEDPC-S
EEWRWKYEEEQRKVVQLEQELVQKTEECKTQAAACLRLENQIREQVQELGLLLSWEPRAS
GR-QASSLQPGGDGMEQGCP---MDLLAESIQELKKQ-QQAAA---TVNPVLALKKAEDS
---APGEIQYEVHGRSQQ-EEQGP-PQSPESETIRKATGQQLTTSGA-------QTFGPD
HADQLPAGQKESS-------------QVLGVEPGGTVAEPVGPA-A-MNQLLLQLREELA
-AVWREK-D---AARGALSRPVMEGALGTPRAEAAAAAWEKMEARLERVLARLERAKAGL
QMKPEVPYQ---ESREGALKAAPGSIK-------EDEEKEKRVPG-ARGEPLGAPGGE--
---KA--LGGLAKGRLEKEVSALRLSNSNLVEELGELGRERQRLQRELQSLSQRLQREFV
PKPEAQVQLQQLRQSVGLLTDELAVEKEATEKLRKLLAAQSSGLRGLWDCLPPDLVGKRS
A-Q--SKAAEPLEELRACITTLVDRHREAQQVLARLQEENRQLRGSLSP--CREP-GTSL
--KAPASPQVAALEQDLGKLEEELRAVQATMSG--KSQEIGKLKQLLYQATEEVAELRAR
EAASLRQHEKTRGSLVAQ----AQAWGQELKALLEKYNTACREMGRLREAVAEERRRSGD
LAAKAAEQERQASEMRGRSEQFEKTAELLKEKMEHLIGACRDKEAKIKELLKKLEQLSEE
VLAIRGENARL-ALQLQDSQKNNEEIISTYRNHLLNAARGYMEHEVYNILLRILSMQEE-
----------

------------------------------------------------------------
-----------------QTQRSCCSATQVERWNRRDQKLL

PF12796 // ENSGT00530000063369_3_Domain_1 (101, 202)

EAVQRGDVGRVAALTSRKSA
RPTKLDSNGQSP---FH---LAASKGLTECLRVLLANGADINSKNE-------DGSTALH
LATISCQPQCVKILLQHGANEDAV---D-AENRSPLHWAA---SSGCASSVLLLCDHEAF
LDVLDNVHGRCPRGEDGHTPLMIASLGGHAAICSQ

PF13857 // ENSGT00530000063369_3_Domain_6 (276, 330)

LLQRGARVNVTDKDDKSALILACEK
GSAEVAELLLSHGADAGAVDSRGNDALHYALCTQDKTLWRLLRQALNRRRRG-GQRLVQH
PDLAS----QASPSEPHV-------------GSPSQSPWRAEPEEEQEEE--EDEDPC-S
EEWRWKYEEEQKKVSRLEQELVQKTEECKAQAVAFLDLESQIREQVQELVLLLSQESRAP
GG-QSSRLRPGGDGMEQGCP---LDLLAERIQELKKQQQAAAIVNQEAKR------VEEW
--SVPG-ETHDVRGKSPP-EEQGP-PQSPRSEATRKSTGQQLTRGG--------QALVPN
HTSQQPADQKERA-------------QASGVEATDTVAEPVGTA-A-MNQLLLQLREELA
-AVWREK-D---AARGAFSRPVLEGALGTPRAEAAAAAWEKMEARLEQVLVRLDQAKASL
KAEPEIPGP---ESRARAPKAAPRCIK-------EYGEKEQLALG-ARGEPLGVPGER--
---F-P-GGGCPKGQLEKEVSALRLSNSNLLEELGELGRERQRLQGELQSLSQRLQREFV
PKPEAQVQLQQLQRSVGLLTEELAKEKEATEKLRKRLE----------------------
--------------------------------------ENRRLRAPQAP--AGEL-AAFS
--KALASPQVEALGQDLRKLEEELRAVQAAMSG--KSQEITKLKQLLYQATEEVAEVRAR
AAASLRQHEKMRGSLVAK----AQAWTA--------------------------------
---LAAQQERQASELRGRSDQFEKTTELLKEKTEHLMEACQDKEAKVKELLKNLEQLSEE
VLSVRGENARL-ALKLQDSQKNSEEIITAYRSHLLNAAQGYMEQDVYNVLLRILSMQE--
----------

------------------------------------------------------------
----------------------------VERWNRRDQKLLEAVQRGDVGRVAALASRKSA
RPTKLDS

PF00023 // ENSGT00530000063369_3_Domain_1 (128, 166)

NGQSP---FH---LAASKGLTECLTILLANGADINSKN

ENSGT00530000063369_3_Linker_1_2 (166, 174)

E-------

PF00023 // ENSGT00530000063369_3_Domain_2 (174, 210)

DGSTALH
LATISCQPQCVKVLLQHGANEDAV---D-

ENSGT00530000063369_3_Linker_2_4 (210, 211)

G

PF00023 // ENSGT00530000063369_3_Domain_4 (211, 219)

ENRSPLHW

ENSGT00530000063369_3_Linker_4_5 (219, 256)

AXXXXXXXXXXXX---------
---XXXXXXXXXXXX

PF00023 // ENSGT00530000063369_3_Domain_5 (256, 288)

DGRTPVMIASLGGHAAICSQLLQRGARVNVTD

ENSGT00530000063369_3_Linker_5_6 (288, 289)

R

PF00023 // ENSGT00530000063369_3_Domain_6 (289, 321)

NDKSALILACEK
GSAEVAELLLSHGADAGAVDSTGHDALHYALHSQDKALQRLLRQALNRRRRG-GQRLVQH
SDLAS----QVSPSEPQV-------------GSPPKSPWRAEPEEEQEEE--DDEDPY-S
EEWRWKYEEEQRKVSQLEQELVQKTEECKAQDAAYLGLENQIREQVQELELLLSQEPGTP
GG-QGSSARPGGDGMEQGCP---LDLLAERIRELKKQHQAAT-----ANPTLEPKKVQES
---VPREIQYEAHEKSQP-E-QGP-PHSPRSETIGKATGQQLTTNGG-------QAVGPG
CMDQPNAGQKERP-------------QAPGAEPAGTVAEQVGSA-A-MNQLLLQLREELA
-AVWREK-D---AARGALSRPVLEGALGTSRAEAAAAAWEKMEARLEQVLVRLDRAKAGL
QVKSEVPAQ---EPRERAPKAATGSIT------KENEEKEKRVPR-ARGEPLGAPGGE--
---QALGXXXXXXXXXXXXX----------------------------------------
-----XXXXXXXXXXXXXXXXXLAMEKEATEKLRKRLASQSSGLRELWDCLPPDLAGKGS
A-W--GTAAMPLEELQTCISTLVDRHRQAQQVLARLEEENQQLRGTPAP--CGEP-GTSS
--KALASPQVAALEQDLGKLEEELRAVQATMSG--KSQEIGKLKQLLYQATEEVAELRAQ
EAANLRQHEKTRASLVAQ----AQAWGQELKALLEKYNTACREMGRLREAVAEERRRSGD
LAASAAEQQRQASEMRGRSEQFEKTAELLKEKTEHLIGACRDKEAKXXXXXXXXXXXXXX
XXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXGYMEQDVYNILLRILSMQEE-
----------

--------------------------------------------------------MKRI
FSCSSSQVA-------------------VERWNRRDQKLLEAVQRGDVGRVAALASRKSA
RPTKLDS

PF00023 // ENSGT00530000063369_3_Domain_1 (128, 166)

NGQSP---FH---LAASKGLTECLTILIANGADINSKN

ENSGT00530000063369_3_Linker_1_2 (166, 174)

E-------

PF00023 // ENSGT00530000063369_3_Domain_2 (174, 210)

DGSTALH
LATISCQPQCVKVLLQHGANEDAV---D-

ENSGT00530000063369_3_Linker_2_3 (210, 211)

A

PF00023 // ENSGT00530000063369_3_Domain_3 (211, 246)

ENRSPLHWAA---SSGCASSVLLLCDHEAF
LDVLD

ENSGT00530000063369_3_Linker_3_5 (246, 256)

N---------

PF00023 // ENSGT00530000063369_3_Domain_5 (256, 288)

DGRTPLMVASLGAHAAICSQLLQRGARVNVTD

ENSGT00530000063369_3_Linker_5_6 (288, 289)

K

PF00023 // ENSGT00530000063369_3_Domain_6 (289, 321)

DDKSALILACEK
GSAEVA-LLLSHGADVGAVDSMGHDALYYGTRTQDKALWKLLQQALSRRRRG-GQGLAQH
PDVAS----KAPPSEPQV-------------GSPPKNSWKAEPEEEQEDE--EDEAPC-S
DEWRWKYEEERRKVSKLEQELGRKEEECKAQAAAYLGLENQIREQVQELGVLLSQELGAP
GG-QGSTLRPGGDGMEQGCP---LDLLAERIQELKKQQRAAAV--GAANLVLAPEKAEDS
--A-PGEVPYKAHGRSQP-EEQRP-LQSPRSETVGNITGQQLPANSG-------EALGPD
HTEQLLAGQKERP-------------RAPGARPTGTVVEPMGTA-A-TPQLLLQLREELA
-AVWREK-D---AAWGALSRPVLEGALGTPQAEAAAAAWEKMEARLEQVLVRLDRAKAGL
QETPEAPAQ---EPKEGAPKVGPETIT------REDEGREQRAPG-ARGEPLGAPGGE--
---QMP-GGGPAKGPLEKEVSALRLSNSNLLEELGTLGRERQRLQGELQSLSQRLQREFV
PKPEAQVQLQQLRRSVGLLTDELAMEKEATEKLRKRLASQSSGLRGLWDCLPPDLVGKGS
A-G--GPATQPLEELQACISTLVARHREAQQVLARLEEENQRLRGSPAQ--RGEP-GASS
--KVPACPEVAALEQDLGKLEEELRAVQATMSG--KSQEIGKLKKLLYQATEEVAELRAR
EAASLRQHEKTRGSLVAQ----AQAWGQELKALLEKYNTACREMGRLREAVAEERRRSGN
LAARAAEQERQAGEMRGRSEQFEKTAELLREKTEHLLGACRDKEAKIKELLKKLEQLSEE
VLAVRGENARL-ALQLQDSQKNHEEVISTYRNHLLNAAQ---------------------
----------

--------------------------------------------------------MKRF
FSCSSSQVA-------------------VEKWNRRDQKLL

PF12796 // ENSGT00530000063369_3_Domain_1 (101, 202)

EAVQRGDVGRVAALASRKSA
RPTKLDSNGQSP---FH---LAASKGLTECLSILLANGADINSKNE-------DGSTALH
LATISCQPQCVKVLLQHGANE

ENSGT00530000063369_3_Linker_1_3 (202, 211)

DAV---D-A

PF12796 // ENSGT00530000063369_3_Domain_3 (211, 287)

ENRSPLHWAA---SSGCASSVLLLCDHEAF
LDVLDN---------DGRTPLMIASLGGHAAICSQLLQRGARVNVSDKDDKSALILACEK
GSAEVAELLLSHGADAGAVDSRGHDALHYALRTQDQVLWRLLRQALNRRRRG-GQRLVQH
PDLAS----QASPSGPHV-------------GSPPKSPWKAEPEEEQEEG--EDEDPC-S
EEWRWKYEEEQKKVSQLEQELVQKTEECKAQAAAYLGLENLIREQVQELGLLLSQEPRAA
GG-QGARLRPGGDGMEQGCP---LDLLAERIQELKKQQQAAAI--VSQKAT-----GVEE
S-P-PGEMRHEVHGKSHS-E-QGS-PQSPGPEAPRRAAGQL--TTGG-------QTLVSS
HTGQQPADEKERP-------------QASGVETTDTAAEPVGAA-A-MNQLLAQLREELA
-AVWREK-D---AARGALSRPILEGALGTPRAEAAAAAWEKMEARLEQVLVRLDRAKAGL
QVKPEVPVQ---ESRAGIPKAAPECNK------EHG-EEKRRGPG-ARGEPLGAPGEQ--
---L-P-GGGLATGQLEKEVSALRRSNNNLLEELGELGRERQRLQGELQSLSQRLQREFV
PKPEAQVQLQQLQKSVGLLTEELATEKEATEKLRKRLASQSSSLQGLWDCLPPDVVGKAS
A-G--GTAAEPLEELHACISTLVDRHREAQQVLAQLEEENQRLQASLGP--DGEP-GPFL
--RAPASPQVAALEQDLGRLEEELRLVQATMSG--KSQEITKLKQLLYQATEEVAELRAR
EAATLRQHEKTRSSLVAQ----AQAWGQELKDVLEKYNTACREMGRLREAMAEERRRSGD
LAALAAEQERQARELRSRSEQFEKTAELLKEKMEHLIEACRDKEAKIKELLKKLEQLSEE
VLSVRGENARL-ALQLQDSQKNSDEIISTYRNHLLNAAQGYMEQDVYNILLRILSVQEE-
----------

--------------------------------------------------------MKRI
FSCSSSQVA-------------------VEKWNRRDQKLL

PF12796 // ENSGT00530000063369_3_Domain_1 (101, 202)

EAVQRGDVGRVAALASRKSA
RPTKLDSNGQSP---FH---LAASKGLTECLTILLANGADINSKNE-------DGSTALH
LATISCQPQCVKVLLQHGANEDAV---D-AENRSPLHWAA---SSGCASSVLLLCDHEAF
LDVLDN---------DGRTPLMIASLGGHAAICSQLLQRGARVNVTDK

PF12796 // ENSGT00530000063369_3_Domain_6 (289, 342)

DDKSALILACEK
GSAEVAELLLSHGADAGAVDSLGHNALHYALRTQDKELWRLLQQALNRRRRG-GHGLVQH
PDHPS----QASSCEPRV-------------GSPPKNSRKVEPEEEQE-E--EGEERC-S
EEWRWKFEEEQRKVHQLEQELVRKTDECKAHAAAFSSLEEQIREQAQELGHLLVQEPGAP
GN-QGPGLRPEGDGMEEGCP---LNLLAERIQELKKQQKALAT----INPTLVPKRAEEL
--A-PAEIHHEVHRKSQP-E-QGL-PQGPSSETTGKATGQQPNTNGG-------QNLGLQ
NTEQVCAGQKERT-------------PAPGTETAGTVGEPVGIA---MNQLLLQLREELA
-AVWREK-D---AARGALSRPVLEGALGTPRAEAAAAAWEKMEARLERVLVRLDGAKMGL
HVKPEVPVQ---GSRDGAPKAVPGCSK------E---QEEKKALG-TRGEPLGAPGKE--
---QA-LGGGLAKGQLEKEVSALRLSNSNLLEELGELGRERQRLQGELQSLTQRLHREFV
PKPEAQVQLQQLRRSVGMLTEELAMEKEATDKLRRLLASQTSGLQGLWKCLPPDLVGKGN
T-Q--STAAEPLEELQACISTLVDRHLEAQRVLARLEEENQQLRGSLAP--CGEP-EASL
--KVTASPQVAALEEDLGMLEEELRAVQATMSG--KSQEICKLKQLLYQATEEVAELRAR
EAASLRQHEKTRGSLVAQ----AQAWGQELKVVLEKYNTACREMTRLRDTVAEERRRSED
LAARAAEQERQAGEMRGRSEQFEKTAELLKEKTNHLIGACRDKEAKIKELLKKLEQLSEE
VLEVRGENAHL-ALQLQDSQKNHEEIISTYRSHLLNAARGYMEQDVYNILLRILSMQE--
----------

--------------------------------------------------------MKRI
FSCSSSQVA-------------------VERWNRRDQKLL

PF12796 // ENSGT00530000063369_3_Domain_1 (101, 202)

EAVQRGDVGRVAALASRKSA
RPTKLASNGQSP---FH---LAASKGLTECLTVLLANGADINSKNE-------DGSTALH
LATISCQPQCVKVLLQHGANE

ENSGT00530000063369_3_Linker_1_3 (202, 211)

DAV---D-A

PF12796 // ENSGT00530000063369_3_Domain_3 (211, 287)

ENRSPLHWAA---SSGCASSVLLLCDHEAF
LDVLDN---------DGRTPLMIAALGGHTAICSQLLQRGARVNVTDKNDKSALILACEK
GSAEVAELLLSHGADVGAVDSAGNDALHYARHTQDEALWRLLQLALNRRRRG-GQRLVQH
PDLAS----QASPSEPQA-------------GSPSKSPWRAEPEEEHEEE--EDEDPC-S
DEWRWKYEEEQGKVAQLEQELVRKTEECKTQAAAYLGLENQIREQVQELGLLLSQEPGTP
GG---SSLRPGGDGMEQGCP---LDLLAERIQELKKQQQAAAM----VNPTLAPKKAKDS
---APGEIQHEVHGRAHP-E-QQP-PQSPRSETLGKTTGQQQTTRGG-------QTHGSE
HTDQPPASQKERP-------------QVLGIEPGGTAVERVGPATA-MNQLLLQLREELA
-AVWREK-D---AARGALSRSILEGALGTHRAEAAAAAWEKMEARLERVLVRLDQAKAGL
QVKPEALAQ---ESREGAPKAVSGIIQ------Q-DEEKEKRASG-SRGEPLGAPGGE--
---QSP-GGGLAKGQLEREVSALRLSNSNLLEELGELGRERQRLQRELQSLSQRLQREFV
PKPEAQGQLQQLRQSVGLLTKELATEKEATEKLRKRLACQSSGLRGLWDCLPPDLVGKGR
A-R--SQAAEPLEELQACISTLVHRHREAQQELGRLEEENQHLRGSLAS--CGEP-GASS
--EAPASPQVAALEQDLGKLEEELRAVQATMSG--KSQEIGKLKQLLYQATEEVAELRAR
EAASLRQHEKTRGSLVAQ----AQAWGQELKALLEKYNTACWEMGQLREAVAEERRRSGD
LAAQAAEQERQTGEMRGRSEQFEKTAELLKEKMERIVGACRDKEAKIKELLKKLEQLSEE
VLAVRGDNARL-ALQLQDSQKNHEEIISTYRNHLLNAARGYMEQDVYNILLRILSVQEA-
----------

--------------------------------------------------------MKRI
FSCSSSQVA-------------------VERWNRRDQKLL

PF12796 // ENSGT00530000063369_3_Domain_1 (101, 202)

EAVQRGDVGRVAALASRKSA
RPTKLDSNGQSP---FH---LAASKGLTECLTILLANGADINSKNE-------DGSTALH
LATISCQPQCVKVLLQHGANE

ENSGT00530000063369_3_Linker_1_3 (202, 211)

DAV---D-A

PF12796 // ENSGT00530000063369_3_Domain_3 (211, 287)

ENRSPLHWAA---SSGCASSVLLLCDHEAF
LDVLDN---------DGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEK
GSAEVAELLLSHGADAGAVDGTGHDALHYALRTQDRTLWRLLRQALNRQGRG-GQGPVQH
LNPES----QASPSESQV-------------GAPPKSPWRAEPEEEQEEE--EDEDPC-S
EEWKWKYEEEKRKVSQLEQELLQKMEECKAQATAYLGLENQIQEHMRELGLLLSQEPRAP
GD-QGSSLRPGGDGMEQGCA---LNLLAKHIQELKKHQQATAA--AAANPVLASKKAEDS
--V-PGEIQYEAQGRSQP-E-QEP-PQSPKSETVGETTGQQLTNSDG-------QALCLD
HTDQLFAGRKERP-------------QAPGSEPTSTVAEPVGTA-A-MNQLLLQLREELA
-AVWREK-D---AARGALSRPVLEGALGTPRAEAAAAAWEKMEARLEQVLVRLDRAKAGL
QMKPQAPAQ---EPREEAPKALPGTIT------QEDEEKEKRVPG-ARGEPLGAPGGD--
---QMA-GGGQARGQLEKEVSALRLSNSNLLEELGQLGRERQRLQGELQSLSQRLQREFV
PRPEAQVQLQQLRRSVGLLTDELALEKEATEKLRKRLASQNRGLQGLWDCLPPDLVGQGS
A-R--GA-AEPLEDLQACISALVARHREAQQGLARLEEENQQLRGSPSR--RGEP-GVST
--KGSASPQVAALEQDLGKLEEELRAVQATMSG--KSQEIGKLKQLLYQATEEVEELRAR
EAASLRQHEKTRGSLVAQ----AQAWGQELKALLEKYNTACREMGRLREAAAEERRRSGD
LAARAAEHERQASEMRGRSEQFEKTAELLKEKVEHLIGACRDKEAKIKELLKKLEQLSEE
VLAVRGDNARL-ALQLQDSQKNHEEIISTYRKHLLNAAQGYMEQDVYNILLRILSIQE--
----------

--------------------------------------------------------MKRF
FSCSSSQVASSQPDKHCQRTCGCLPTDWVERWNRHDQKL

PF12796 // ENSGT00530000063369_3_Domain_1 (100, 202)

LEAVQKGDVGRVAALASRKSA
RPTKLDSNGQSP---FH---LAASKGLTECLSILLANGADINSKNE-------DGSTALH
LATISCQPQCVKVLLQHGANE

ENSGT00530000063369_3_Linker_1_3 (202, 211)

DAV---D-A

PF12796 // ENSGT00530000063369_3_Domain_3 (211, 287)

ENRSPLHWAA---SSGCASSVLLLCDHEAF
LDVLDN---------DGRTPLMIASLGGHAAICSQLLQRGARVNVSDKDDKSALILACEK
GSAEVAELLLSHGADAGAVDSRGHDALHYALRTQDKALWRLLRQALNRRLRG-GQRLVQH
PDLAS----QASPSEPHV-------------GSPPKSPWRAEPEEEQEEE--EDEDPC-S
EEWKWKYEEEQKKVSQLEQELVRKTEECKAQAAAYLGLENQIQEQVQELGLLLSQESRAP
GG-QGSRPRPGGDGMEQGCP---LDLLAERIRELKKQQQAAAVVSQE------AKRVEES
---AAGEMQHEVHGKSQP-EEQGP-PQSPGSEVTRKATGQRLTSGA--------QTLVPN
QTGQQPADQKERP-------------QASGVETTDTAAEPVGTA-A-MNQLLLQLREELA
-AVWREK-D---AARGVLSRPVLEGALGTPQAEAAAAAWEKMEARLEQVLVRLDRAKAGL
QAKPEVPGQ---ESRAGVPKAALGCNK-------EHGEKEKRARG-TRGEPLGAPGEQ--
---L-P-GGGLAKGQLEKEVSALRLSNNNLLEELGELGRERQRLQGELQSLSQRLQREFV
PKPEAQVQLQQLQKSVGLLTDELAMEKEATEKLRKRLASQSSGLRGLWDCLPPDVVGKAS
A-W--STAAEPLEELHTCISTLVDRHREAQKVLSQLEEENQRLRASLVP--GGEP-GAFF
--KAPASPQVAALEQDLGRLEEELRVVQATMSG--KSQEIAKLKQLLYQATEEVAELRAR
EAATLRQHEKTRGSLVAQ----AQAWGQELKDVLEKYNTACREMGRLREAAAEERRRSGD
LAALATEQERQASELRGRSEQFEKTAELLKEKTEHLIEACRDKEAKIKELLKKLEQLSEE
VLSVRGENACL-ALQLQDSQKNNEEIITAYRNHLLSAAQGYMEQEVYNILLRILSMQEE-
----------

--------------------------------------------------------MKRI
FSCSSTQVA-------------------VERWNRHDQKLLEAVHRGDVG

PF12796 // ENSGT00530000063369_3_Domain_1 (110, 202)

RVAALASRKSA
RPTKLDSNGQSP---FH---LAASKGLTECLTILLANGADINSKNE-------DGSTALH
LATISCQPQCVKVLLQHGANEDAV---D-AENRSPLHWAA---SSGCASSVLLLCDHEAF
LDVLDN---------DGCTPLMIASLGGHAAICSQLLQRGARVNVTD

PF12796 // ENSGT00530000063369_3_Domain_6 (288, 343)

KNDKSALILACEK
GSAEVAELLLSHGADAGAVDSTGHDALHYALHTQDKALWRLLQQALNRRRRG-GQRLVQH
PDLTS----QASPSEPQA-------------GSPPKSSWKAEPEEEQEEK--EDEDPC-S
EEWRWKYEEERRKVVQLEQELVQKTEECKTQAAAYLDPENQIREQAQELGVLLSWEPRAS
GK-QGSSLRPGGDGMEQGCP---KDLLAESTQELKKQ-QQAAA---TVNPVLAPKKAEDS
---APGKIQYEVHGRSQP-EEQGP-PQSPASETIRKVTGQQLPTNGA-------QTFGPD
HADQLPAGQKESS-------------QVLGVEPGGTVAEPVSPA-A-MNQLLLQLREELA
-AVWREK-D---AARGALSRPVMEGALGTPRAEAAAAAWEKMEARLERVLARLEWAKAGL
RVKPEVPSQ---ESREGALKAAPGSIK-------QDEEKEKRVPG-ARGEPLGALGGE--
---KA--LGGLAKGQLEKEMSVLRLSNSNLLEELGELGRERQRLQRELQSLTQRLQREFV
PKPEAQVQLQQLRQSVGLLTNELAMEKEATEKLRKLLASQSSGLRGLWDCLPADLVGKRS
A-Q--SKAAESLEELRACISTLVDRHREAQQVLARLQEENQQLRGSLSP--CREP-STSL
--KAPASPQVAALEQDLGKLEEELRAVQATMSG--KSQEIGKLKQLLYQATEEVAELRAR
EAASLRQHEKTRGSLVAQ----AQAWGQELKALLEKYNTACREMGRLREAVAEERRRSGD
LAAQAAEQERQASEMRGRSEQFEKTAELLKEKMEHLIGACRDKEAKIKELLKKLEQLSEE
VLAIRGENARL-ALQLQDSQKNHEEIISTYRNHLLNAARGYMEHEVYNILLQILSMEEE-
----------

--------------------------------------------------------MKRI
FSCSSSQVA-------------------VERWNRRDQKLLEAVQRGDVGRVAALASRKSA
RPTKLDP

PF00023 // ENSGT00530000063369_3_Domain_1 (128, 166)

SGQSP---FH---LAASKGLTECLMLLLANGADINSKNEDXXXXXXXXXXXXX
XXXXXXXXXXXXXXXX-------X---X----XXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXX---------

PF00023 // ENSGT00530000063369_3_Domain_5 (256, 288)

DGRTPLMIASLGGHAAICSQLLQRGARVNVTD

ENSGT00530000063369_3_Linker_5_6 (288, 289)

K

PF00023 // ENSGT00530000063369_3_Domain_6 (289, 321)

DDKSALILACER
GSAEVAELLLSHGADAGALDSTGHDALHYALRTQDQALWGLLQQALDRRRRG-GQGLVQH
PDAAS----KASASEPQA-------------GCRPKSPWRAEPKAEEQGE-EEGKGPC-S
EEWRSKYEEEQRKVSQLEQELERKTEACRAQAEAYVGLENQIRERVQELGSLLSREAGAE
DS-HGCSDRPGGDGMEQGGP---LDLLAERIQELKRQHQAVGA--AA-KSALTPCTSENA
A-PQENLHLLGTRDKVHP-EEEGS-LQSPRSETPKEVTAQPVT------------ALSPE
HAHHPHTGREGRA-------------QASGVAPA---VEPGGSA-A-LNQLLLQLREELA
-AVWREK-E---AARGALSRSSQEGAVGSPRAEAAAAAWEKMEARLERVLARLDRAKAGL
QVNAEGKG-------------ATGAVA------KEAEEQEDRAPG-VRGEPLEAHGAE--
---QD--LGGLGKGQLEKEVSALRLSNSNLLEELGELGRERQRLQGELRAMSQRLQREFV
PKPEAQVQ

PF05701 // ENSGT00530000063369_3_Domain_8 (849, 883)

LQQLRQSVGLLTDELATEKEATEKLRARLASQSSGLRGLWDCLPPDLVGAGP
T------AADPLHQLQACVRALVQGHREAQQVLARLQEENQQLRGLSGP--QGDP-GASP
--GAAAAPQVAALEQDLGKLEEELRAVQATMRG--KSQEIGKLKQLLYQATEEVAELRAR
EAASLRQHERTRGSLVAQ----AQAWGQELKALLEKYNAAC-------------------
------------------------------------------------------------
------------------------------------------------------------
----------

---------------------------------------------------------RFW
VSVSSSSYM-------------------VEKWNRRDQKLL

PF12796 // ENSGT00530000063369_3_Domain_1 (101, 202)

EAVQRGDVGRVAALASRKSA
RPTKLDSNGQSP---FH---LAASKGLTECLSILLTNGADINSKNE-------DGSTALH
LATISCQPQCVKVLLQHGANEDAV---D-AENRSPLHWAA---SSGCASSVLLLCDHEAF
LDVLDN---------DGRTPLMIASLGGHAAICSQLLQRGARVNVTDK

PF12796 // ENSGT00530000063369_3_Domain_6 (289, 342)

DDKSALILACEK
GSAEVAELLLSHGADAGAVDSLGHNALHYALRTQDKELWRLLQQALNRRRRG-GHGLVQH
PDHVS----QTSPPEPQV-------------GSPPKSSRRAEPEEAQQEE-EEAEERC-S
EEWGWKYEEEQRKVNQLEQELLRKTEECKAQAAALKGLENQVREQVQELGHLLVQEPRAP
G-------RPGGDGMEQGCP---LNLLAERIQELKRQQKAAAT----INPTVVARRAEEL
---AVAEIQGEVHSKSQP-EQ--GPPQSPRSESIGKVTGQQLNANGG-------QNLGLD
NTDQVCVGQKERS-------------PAPGTEQAGAVGEPVGIA-A-MNQLLLQLRDELA
-AVWREK-D---AARGALSRPVLEGALGTPRAEAAAAAWEKMEARLERVMVRLDRAKAGL
QVKPEVPAQ---GSREGAPKAVPGCTK--------KHEEEKRAPG-ARGEPLGAPGGE--
---QAS-GGGLAKGHLEKEVSALRLSNSNLMEELGELGRERQRLQGELQSLTQRLQREFV
PKPEAQVQLQQLRRSVGLLTEELAMEKETTENLRRQLASQSSGLQGLRNCLPPDLVGKES
A-G--STAAEPLEELQTCISTLVNKHLEAQKALARLEEENQQLRGSLVP--CGKP-EASL
--KATASPQVAALEQDLGMLEEELRAVQATMSG--KSQEICKLKQLLYQATEEVAELRAR
ETASLRQHEKTRSSLVAQ----AQAWGQELKVVLEKYNTACREMARLRDAAAEERRRSED
LAARAAEQERQAGEMRGRSEQFEKTVELLKEKTDHLIGACRDKEAKIKELLKTLEKLSEE
VLQVRGENTQL-ALQLQDSQKNHEETISTYRNHLLNAARGYMEQDVYNILLRILSMQE--
----------

--------------------------------------------------------MKRI
FSCSSSQVA-------------------VEKWNRRDQKLLEAVQRGDVGRVAALASRKSA
RPTKLDS

PF00023 // ENSGT00530000063369_3_Domain_1 (128, 165)

NGQSP---FH---LAASKGLTECLTILLANGADINSK

ENSGT00530000063369_3_Linker_1_2 (165, 174)

NE-------

PF00023 // ENSGT00530000063369_3_Domain_2 (174, 208)

DGSTALH
LATISCQPQCVKVLLQHGANEDAV---D-GENRSPLHWAA---SSGCASSVLLLCDHEAF
LDVLDN---------

PF00023 // ENSGT00530000063369_3_Domain_5 (256, 288)

DGRTPLMIASLGGHAAICSQLLQRGARVNVTD

ENSGT00530000063369_3_Linker_5_6 (288, 291)

KND

PF00023 // ENSGT00530000063369_3_Domain_6 (291, 320)

KSALILACEK
GSAEVAELLLSHGADAGAVDSMGHDALHYALHSQDKALWRLLQQALNRRRRR-GQGLVQR
SDLPS----RASPSEPQV-------------DSPPKSPWRAEPEEEQEEE--EVEDPY-S
EEWRWKYEEEQRKVSRLEQQLVQKTEECKAQAAAYVGLENQIREQVQELGLLLSQEPGAP
GR-PGTSARPGGDGMEQGCP---LDQLAERIQELKKQHQAA-R----ANPVPAPTKAQDS
--A-PRELQYETHGSHPE-E-QGT-PHNPRSETIRKATEQQLTTSGR-------QALDPG
QTDQPDAGRKERP-------------RAPGAEPAGTAAEPVGSA-A-MNQLLLQLREELA
QTVWREK-D---AARGALSRPILEEALGTPRAEAAAAAWEKMEARLERVLVRLDRAKAGL
QARPEAPGR---EPREGAPKVAPGSHT------KKDEEKEKRVPG-ARGEPLGAPGGE--
---QA-LGGGLAKGHLEKEVSALRLSNSNLLEELGELGRERQRLQGELQSLSQQLQREFV
PKPEAQVQLQQLRRSVGLLTDELAVEKEAAEKLRKRLASQSSGLRELWDCLPPDLVGKES
A-R--SV-ASPLEELQACIGTLVDRHRQAQQVLARLEEENQQLRRTPVP--RGEP-GASP
--QAPASPQVAALEQDLGKLEEELRAVQATMSG--KSQEIGKLKQLLYQATEEVAELRAR
EAASLRQHEKTRGSLVAQ----AQAWGQELKALLEKYNTACREMGRLREAVAEERRRSGD
LASRAAEQERQAGELRGRSEQFEKTAELLKEKTEHLIGACRDKEAKIKELLKKLEQLSEE
VLAVRGENAHL-ALQLQESQKNHEEIISTYRNHLLNAARGYMEQDVYNILLRILSTQEE-
----------

------------------------------------------------------------
-----------------------VKRREVEKWNRRDQKLL

PF12796 // ENSGT00530000063369_3_Domain_1 (101, 202)

EAVQRGDVGRVASLASRKSA
RPTKLNSSGQSS---FH---LAASKGLTECLTILLANGADINSKNE-------DGSTALH
LATISCQPQCVKVLLQHGANE

ENSGT00530000063369_3_Linker_1_3 (202, 211)

DAV---D-A

PF12796 // ENSGT00530000063369_3_Domain_3 (211, 287)

ENRSPLHWAA---SSGCASSVLLLCDHEAF
LNVPDN---------DGRTPLMIASLGGHAAICSQLLQRGAQVNVTDKDAKSALILACEK
GSAEVAELLLSHGADAGAVDNEGHDALHYAVRSEDRELWRLLRQALLRQGRQGGQGLAQH
PDLTS----QASPSESQV-------------GSPPQSPWRAEPEEEE------EEDPC-P
DEWRRKYEEEQRKVSQLEQELVRKTEESEARAAACLGLENGIREQVQELGLLLSPQPGTP
GG-QGSSLRPGGDGMEQGCP---LDLLAERIQELKKQQQAAAA--AAAKRALASKKAEDS
---VSGEVPYEAPGGAQP-EEQGP-PQSPRSETIGKATGQQLTTSGG-------QALGPD
HTDKPRAGQKEGP-------------RAPGAEPAGTVAAPVGPG-D-VNQLLLQLREELA
-AVWREK-D---AARGALSRPVLEGALGTPRAEAAAAAWEKMEARLEQVLVRLDRAKAGL
PVSPDAA-A---RPREGALHAGPETTS------EENEGGRPGAPG-ARGEPLGAPARG--
---QVP-GGGPAKGRLEKEVAALRLSNSNLLGELGQLGQERQRLQGEPQSLSQRLQRDFV
PKPEAQDQLRQLRRSVGLLTDELAAEKEATEQLRQRLASQSSGLRGLWDDLPPDVVGRXX
XXX--X-----------------XALADGHPSLARLEQENQRLRGSPGP--RGEPPGTFS
--QGPVSPQVAALEQDLGKLEEELRAVQATMSG--KSQEIGTLKKLLYQATEEVAELRAR
EAASLRQHEKTRGSLVAQ----AQAWGQELKALLEKYNTACREMGRLREAAAEERRRSGD
LAARAAEQERQAAELRGRSQQFEKTAEVLRDKVEHLIGACRDKEAKIKELLKKLEQLSEE
VLAVRGENARL-ALQLQDSQKNHEEIISAYRKHLLNAAQGYMEQDVYNILLRILSIQEE-
----------

--------------------------------------------------------MKRI
FSCSSSQVA-------------------VERWNRRDQKLL

PF12796 // ENSGT00530000063369_3_Domain_1 (101, 202)

EAVQQGDVGRVAALASRKSA
RPTKLDSNGQSP---FH---LAASKGLTECLTLLLANGADINSKNE-------DGSTALH
LATISCQPQCVKVLLQHGANE

ENSGT00530000063369_3_Linker_1_3 (202, 211)

DAV---D-A

PF12796 // ENSGT00530000063369_3_Domain_3 (211, 287)

ENRSPLHWAA---SSGCASSVLLLCDHEAF
LDVLDN---------DGRTPLMIASLGGHTAICSQLLQRGARVNVTDKNDKSALILACEK
GSAEVAELLLSHGADAGAVDSTGHDALHYALHTQDKSLWRLLQQALNRRQRG-GQRLVQH
PDLAS----QASPSEPQA-------------GSPPKSPWRAEPEEEQEEE--EDEDPS-S
EEWRWKYEEEQKKVVQLEQELVQKTEECKTQAAACLRLENQIREQVQELGLLLSWEPRAS
GR-QGSSLRPGGDGMEQGCP---MDLLAERIQELKKQ-QQAAA---TVNPVLALKKAEDS
---APGEIQYEVHGRSQQ-EEQGP-PQSPESETIRKTTGQQLTTSGA-------QTFGHD
HADQLPAGQKESS-------------QVLGVEPGGTVAEPVGPA-A-MNQLLLQLREELA
-AVWREK-D---AARGALSRPVMEGALGTPRAEAAAAAWEKMEARLECVLARLERAKAGL
QVKPEVPSQ---ESREGALKAAPGSIR-------EDEEKEKRVPG-ARGEPLGAPGGE--
---KA--LGGLAKGQLEKEVSALRLSNSNLVEELGELGRERQRLQRELQSLSQRLQREFV
PKPEAQVQLQQLRQSVGLLTDELAVEKEATEKLRKLLAAQSSGLRGLWDCLPPDLVGKRS
A-Q--SKAAEPLEELRACITTLVDRHREAQQVLARLQEENRQLRGSLSP--CREP-GTSL
--KAPASPQVAALEQDLGKLEEELRAVQATMSG--KSQEIGKLKQLLYQATEEVAELRAR
EAASLRQHEKTRGSLVAQ----AQAWGQELKALLEKYNTACREMGRLREAVAEERRLSGD
LAAKAAEQERQASEMRGRSEQFEKTAELLKEKMEHLIGACRDKEAKIKELLKKLEQLSEE
VLAIRGENARL-ALQLQDSQKNNEEIISTYRNHLLNAARGYMEHEVYNILLRILSMQEE-
----------

------------------------------------------------------------
-----------------------------------------------------------F
SPPITDS-A-

PF00023 // ENSGT00530000063369_3_Domain_1 (131, 166)

LSPPRFH---LAAARGLTDILNIIISYKVEVNAKS

ENSGT00530000063369_3_Linker_1_2 (166, 174)

D-------

PF00023 // ENSGT00530000063369_3_Domain_2 (174, 206)

EGCTALH
LAASHCHPECVKLLLQVRSGTNMAAWFH---TRIPRVIPC-RATRGNWGSWPLI------
----------CHVSQ

PF00023 // ENSGT00530000063369_3_Domain_5 (256, 288)

DSRTPLMTAAIRNHPTVCALLLERGAQIDLHDKDAXIVGILEAEI
GDIRGT-----VAIDRGSWWIRDDPRCYFSLCIN---------ISFSFLERGTGQDNQ-H
V----------------V------------KGHH------------HSR---GKEDEM-V
NIWKKRYEEEHKRGLWLQGDLMRKTHEIEGLLEENRSEKRRMREMVEKLKDLLDGPTEEQ
--------DPTEDDFQTTDIFLSISRAVEQIKAIREQKLKPHELQEEKLKTLEAKRVQEG
HQEAMRHLQDEVVAAK---EREGV-AQKRVAELEGHLENMRLVLSQFETRKRIDSTVVED
LQEQINELTREREELLERLEKQQENLNKSKNEELNDGQNTLHANVRVLKEFLNSLKSDCI
--------RVQTKAVDMYGRESLTGFVPVGVLEQSAESWKKISSAIETHLVNHVPSQSNL
LVNGSFSEKADAAPRQSLPEVEVS-------------------------VPVSA------
---------CGNINHLTREASEKNIETQKSIDA---------------------------
------------------------------------------------------------
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----------